data_5HZ3 # _entry.id 5HZ3 # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 5HZ3 WWPDB D_1000217986 # loop_ _pdbx_database_related.db_name _pdbx_database_related.details _pdbx_database_related.db_id _pdbx_database_related.content_type PDB . 5HZ1 unspecified PDB . 5HZ0 unspecified PDB . 5HYX unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.entry_id 5HZ3 _pdbx_database_status.recvd_initial_deposition_date 2016-02-02 _pdbx_database_status.SG_entry N _pdbx_database_status.deposit_site PDBJ _pdbx_database_status.process_site PDBJ _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? _pdbx_database_status.pdb_format_compatible Y # loop_ _audit_author.name _audit_author.pdbx_ordinal _audit_author.identifier_ORCID 'Song, W.' 1 ? 'Han, Z.' 2 ? 'Chai, J.' 3 ? # _citation.abstract ? _citation.abstract_id_CAS ? _citation.book_id_ISBN ? _citation.book_publisher ? _citation.book_publisher_city ? _citation.book_title ? _citation.coordinate_linkage ? _citation.country ? _citation.database_id_Medline ? _citation.details ? _citation.id primary _citation.journal_abbrev 'To Be Published' _citation.journal_id_ASTM ? _citation.journal_id_CSD 0353 _citation.journal_id_ISSN ? _citation.journal_full ? _citation.journal_issue ? _citation.journal_volume ? _citation.language ? _citation.page_first ? _citation.page_last ? _citation.title 'Plant Receptor' _citation.year ? _citation.database_id_CSD ? _citation.pdbx_database_id_DOI ? _citation.pdbx_database_id_PubMed ? _citation.unpublished_flag ? # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Song, W.' 1 primary 'Han, Z.' 2 primary 'Chai, J.' 3 # _cell.length_a 179.174 _cell.length_b 179.174 _cell.length_c 88.402 _cell.angle_alpha 90.000 _cell.angle_beta 90.000 _cell.angle_gamma 120.000 _cell.entry_id 5HZ3 _cell.Z_PDB 9 _cell.pdbx_unique_axis ? # _symmetry.space_group_name_H-M 'H 3' _symmetry.entry_id 5HZ3 _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 146 # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'Probable LRR receptor-like serine/threonine-protein kinase At4g26540' 69202.875 1 2.7.11.1 'V64T, G81E, M82K, D83Q, N104Q' 'UNP residues 57-689' ? 2 polymer syn ASP-PTR-PRO-LYS-PRO-SER-THR-ARG-PRO-HYP-ARG-HIS-ASN 1664.714 1 ? ? ? ? 3 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 4 ? ? ? ? # loop_ _entity_poly.entity_id _entity_poly.type _entity_poly.nstd_linkage _entity_poly.nstd_monomer _entity_poly.pdbx_seq_one_letter_code _entity_poly.pdbx_seq_one_letter_code_can _entity_poly.pdbx_strand_id _entity_poly.pdbx_target_identifier 1 'polypeptide(L)' no no ;CNWTGVKCNRRGEVSEIQLKEKQLQGSLPVTSLRSLKSLTSLTLSSLQLTGVIPKEIGDFTELELLDLSDNSLSGDIPVE IFRLKKLKTLSLNTNNLEGHIPMEIGNLSGLVELMLFDNKLSGEIPRSIGELKNLQVLRAGGNKNLRGELPWEIGNCENL VMLGLAETSLSGKLPASIGNLKRVQTIAIYTSLLSGPIPDEIGYCTELQNLYLYQNSISGSIPTTIGGLKKLQSLLLWQN NLVGKIPTELGNCPELWLIDFSENLLTGTIPRSFGKLENLQELQLSVNQISGTIPEELTNCTKLTHLEIDNNLITGEIPS LMSNLRSLTMFFAWQNKLTGNIPQSLSQCRELQAIDLSYNSLSGSIPKEIFGLRNLTKLLLLSNDLSGFIPPDIGNCTNL YRLRLNGNRLAGSIPSEIGNLKNLNFVDISENRLVGSIPPAISGCESLEFLDLHTNSLSGSLLGTTLPKSLKFIDFSDNA LSSTLPPGIGLLTELTKLNLAKNRLSGEIPREISTCRSLQLLNLGENDFSGEIPDELGQIPSLAISLNLSCNRFVGEIPS RFSDLKNLGVLDVSHNQLTGNLNVLTDLQNLVSLNISYNDFSGDLPNTPFFRRLPLSDLASNRGLYISNAIST ; ;CNWTGVKCNRRGEVSEIQLKEKQLQGSLPVTSLRSLKSLTSLTLSSLQLTGVIPKEIGDFTELELLDLSDNSLSGDIPVE IFRLKKLKTLSLNTNNLEGHIPMEIGNLSGLVELMLFDNKLSGEIPRSIGELKNLQVLRAGGNKNLRGELPWEIGNCENL VMLGLAETSLSGKLPASIGNLKRVQTIAIYTSLLSGPIPDEIGYCTELQNLYLYQNSISGSIPTTIGGLKKLQSLLLWQN NLVGKIPTELGNCPELWLIDFSENLLTGTIPRSFGKLENLQELQLSVNQISGTIPEELTNCTKLTHLEIDNNLITGEIPS LMSNLRSLTMFFAWQNKLTGNIPQSLSQCRELQAIDLSYNSLSGSIPKEIFGLRNLTKLLLLSNDLSGFIPPDIGNCTNL YRLRLNGNRLAGSIPSEIGNLKNLNFVDISENRLVGSIPPAISGCESLEFLDLHTNSLSGSLLGTTLPKSLKFIDFSDNA LSSTLPPGIGLLTELTKLNLAKNRLSGEIPREISTCRSLQLLNLGENDFSGEIPDELGQIPSLAISLNLSCNRFVGEIPS RFSDLKNLGVLDVSHNQLTGNLNVLTDLQNLVSLNISYNDFSGDLPNTPFFRRLPLSDLASNRGLYISNAIST ; B ? 2 'polypeptide(L)' no yes 'D(PTR)PKPSTRP(HZP)RHN' DYPKPSTRPPRHN A ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 CYS n 1 2 ASN n 1 3 TRP n 1 4 THR n 1 5 GLY n 1 6 VAL n 1 7 LYS n 1 8 CYS n 1 9 ASN n 1 10 ARG n 1 11 ARG n 1 12 GLY n 1 13 GLU n 1 14 VAL n 1 15 SER n 1 16 GLU n 1 17 ILE n 1 18 GLN n 1 19 LEU n 1 20 LYS n 1 21 GLU n 1 22 LYS n 1 23 GLN n 1 24 LEU n 1 25 GLN n 1 26 GLY n 1 27 SER n 1 28 LEU n 1 29 PRO n 1 30 VAL n 1 31 THR n 1 32 SER n 1 33 LEU n 1 34 ARG n 1 35 SER n 1 36 LEU n 1 37 LYS n 1 38 SER n 1 39 LEU n 1 40 THR n 1 41 SER n 1 42 LEU n 1 43 THR n 1 44 LEU n 1 45 SER n 1 46 SER n 1 47 LEU n 1 48 GLN n 1 49 LEU n 1 50 THR n 1 51 GLY n 1 52 VAL n 1 53 ILE n 1 54 PRO n 1 55 LYS n 1 56 GLU n 1 57 ILE n 1 58 GLY n 1 59 ASP n 1 60 PHE n 1 61 THR n 1 62 GLU n 1 63 LEU n 1 64 GLU n 1 65 LEU n 1 66 LEU n 1 67 ASP n 1 68 LEU n 1 69 SER n 1 70 ASP n 1 71 ASN n 1 72 SER n 1 73 LEU n 1 74 SER n 1 75 GLY n 1 76 ASP n 1 77 ILE n 1 78 PRO n 1 79 VAL n 1 80 GLU n 1 81 ILE n 1 82 PHE n 1 83 ARG n 1 84 LEU n 1 85 LYS n 1 86 LYS n 1 87 LEU n 1 88 LYS n 1 89 THR n 1 90 LEU n 1 91 SER n 1 92 LEU n 1 93 ASN n 1 94 THR n 1 95 ASN n 1 96 ASN n 1 97 LEU n 1 98 GLU n 1 99 GLY n 1 100 HIS n 1 101 ILE n 1 102 PRO n 1 103 MET n 1 104 GLU n 1 105 ILE n 1 106 GLY n 1 107 ASN n 1 108 LEU n 1 109 SER n 1 110 GLY n 1 111 LEU n 1 112 VAL n 1 113 GLU n 1 114 LEU n 1 115 MET n 1 116 LEU n 1 117 PHE n 1 118 ASP n 1 119 ASN n 1 120 LYS n 1 121 LEU n 1 122 SER n 1 123 GLY n 1 124 GLU n 1 125 ILE n 1 126 PRO n 1 127 ARG n 1 128 SER n 1 129 ILE n 1 130 GLY n 1 131 GLU n 1 132 LEU n 1 133 LYS n 1 134 ASN n 1 135 LEU n 1 136 GLN n 1 137 VAL n 1 138 LEU n 1 139 ARG n 1 140 ALA n 1 141 GLY n 1 142 GLY n 1 143 ASN n 1 144 LYS n 1 145 ASN n 1 146 LEU n 1 147 ARG n 1 148 GLY n 1 149 GLU n 1 150 LEU n 1 151 PRO n 1 152 TRP n 1 153 GLU n 1 154 ILE n 1 155 GLY n 1 156 ASN n 1 157 CYS n 1 158 GLU n 1 159 ASN n 1 160 LEU n 1 161 VAL n 1 162 MET n 1 163 LEU n 1 164 GLY n 1 165 LEU n 1 166 ALA n 1 167 GLU n 1 168 THR n 1 169 SER n 1 170 LEU n 1 171 SER n 1 172 GLY n 1 173 LYS n 1 174 LEU n 1 175 PRO n 1 176 ALA n 1 177 SER n 1 178 ILE n 1 179 GLY n 1 180 ASN n 1 181 LEU n 1 182 LYS n 1 183 ARG n 1 184 VAL n 1 185 GLN n 1 186 THR n 1 187 ILE n 1 188 ALA n 1 189 ILE n 1 190 TYR n 1 191 THR n 1 192 SER n 1 193 LEU n 1 194 LEU n 1 195 SER n 1 196 GLY n 1 197 PRO n 1 198 ILE n 1 199 PRO n 1 200 ASP n 1 201 GLU n 1 202 ILE n 1 203 GLY n 1 204 TYR n 1 205 CYS n 1 206 THR n 1 207 GLU n 1 208 LEU n 1 209 GLN n 1 210 ASN n 1 211 LEU n 1 212 TYR n 1 213 LEU n 1 214 TYR n 1 215 GLN n 1 216 ASN n 1 217 SER n 1 218 ILE n 1 219 SER n 1 220 GLY n 1 221 SER n 1 222 ILE n 1 223 PRO n 1 224 THR n 1 225 THR n 1 226 ILE n 1 227 GLY n 1 228 GLY n 1 229 LEU n 1 230 LYS n 1 231 LYS n 1 232 LEU n 1 233 GLN n 1 234 SER n 1 235 LEU n 1 236 LEU n 1 237 LEU n 1 238 TRP n 1 239 GLN n 1 240 ASN n 1 241 ASN n 1 242 LEU n 1 243 VAL n 1 244 GLY n 1 245 LYS n 1 246 ILE n 1 247 PRO n 1 248 THR n 1 249 GLU n 1 250 LEU n 1 251 GLY n 1 252 ASN n 1 253 CYS n 1 254 PRO n 1 255 GLU n 1 256 LEU n 1 257 TRP n 1 258 LEU n 1 259 ILE n 1 260 ASP n 1 261 PHE n 1 262 SER n 1 263 GLU n 1 264 ASN n 1 265 LEU n 1 266 LEU n 1 267 THR n 1 268 GLY n 1 269 THR n 1 270 ILE n 1 271 PRO n 1 272 ARG n 1 273 SER n 1 274 PHE n 1 275 GLY n 1 276 LYS n 1 277 LEU n 1 278 GLU n 1 279 ASN n 1 280 LEU n 1 281 GLN n 1 282 GLU n 1 283 LEU n 1 284 GLN n 1 285 LEU n 1 286 SER n 1 287 VAL n 1 288 ASN n 1 289 GLN n 1 290 ILE n 1 291 SER n 1 292 GLY n 1 293 THR n 1 294 ILE n 1 295 PRO n 1 296 GLU n 1 297 GLU n 1 298 LEU n 1 299 THR n 1 300 ASN n 1 301 CYS n 1 302 THR n 1 303 LYS n 1 304 LEU n 1 305 THR n 1 306 HIS n 1 307 LEU n 1 308 GLU n 1 309 ILE n 1 310 ASP n 1 311 ASN n 1 312 ASN n 1 313 LEU n 1 314 ILE n 1 315 THR n 1 316 GLY n 1 317 GLU n 1 318 ILE n 1 319 PRO n 1 320 SER n 1 321 LEU n 1 322 MET n 1 323 SER n 1 324 ASN n 1 325 LEU n 1 326 ARG n 1 327 SER n 1 328 LEU n 1 329 THR n 1 330 MET n 1 331 PHE n 1 332 PHE n 1 333 ALA n 1 334 TRP n 1 335 GLN n 1 336 ASN n 1 337 LYS n 1 338 LEU n 1 339 THR n 1 340 GLY n 1 341 ASN n 1 342 ILE n 1 343 PRO n 1 344 GLN n 1 345 SER n 1 346 LEU n 1 347 SER n 1 348 GLN n 1 349 CYS n 1 350 ARG n 1 351 GLU n 1 352 LEU n 1 353 GLN n 1 354 ALA n 1 355 ILE n 1 356 ASP n 1 357 LEU n 1 358 SER n 1 359 TYR n 1 360 ASN n 1 361 SER n 1 362 LEU n 1 363 SER n 1 364 GLY n 1 365 SER n 1 366 ILE n 1 367 PRO n 1 368 LYS n 1 369 GLU n 1 370 ILE n 1 371 PHE n 1 372 GLY n 1 373 LEU n 1 374 ARG n 1 375 ASN n 1 376 LEU n 1 377 THR n 1 378 LYS n 1 379 LEU n 1 380 LEU n 1 381 LEU n 1 382 LEU n 1 383 SER n 1 384 ASN n 1 385 ASP n 1 386 LEU n 1 387 SER n 1 388 GLY n 1 389 PHE n 1 390 ILE n 1 391 PRO n 1 392 PRO n 1 393 ASP n 1 394 ILE n 1 395 GLY n 1 396 ASN n 1 397 CYS n 1 398 THR n 1 399 ASN n 1 400 LEU n 1 401 TYR n 1 402 ARG n 1 403 LEU n 1 404 ARG n 1 405 LEU n 1 406 ASN n 1 407 GLY n 1 408 ASN n 1 409 ARG n 1 410 LEU n 1 411 ALA n 1 412 GLY n 1 413 SER n 1 414 ILE n 1 415 PRO n 1 416 SER n 1 417 GLU n 1 418 ILE n 1 419 GLY n 1 420 ASN n 1 421 LEU n 1 422 LYS n 1 423 ASN n 1 424 LEU n 1 425 ASN n 1 426 PHE n 1 427 VAL n 1 428 ASP n 1 429 ILE n 1 430 SER n 1 431 GLU n 1 432 ASN n 1 433 ARG n 1 434 LEU n 1 435 VAL n 1 436 GLY n 1 437 SER n 1 438 ILE n 1 439 PRO n 1 440 PRO n 1 441 ALA n 1 442 ILE n 1 443 SER n 1 444 GLY n 1 445 CYS n 1 446 GLU n 1 447 SER n 1 448 LEU n 1 449 GLU n 1 450 PHE n 1 451 LEU n 1 452 ASP n 1 453 LEU n 1 454 HIS n 1 455 THR n 1 456 ASN n 1 457 SER n 1 458 LEU n 1 459 SER n 1 460 GLY n 1 461 SER n 1 462 LEU n 1 463 LEU n 1 464 GLY n 1 465 THR n 1 466 THR n 1 467 LEU n 1 468 PRO n 1 469 LYS n 1 470 SER n 1 471 LEU n 1 472 LYS n 1 473 PHE n 1 474 ILE n 1 475 ASP n 1 476 PHE n 1 477 SER n 1 478 ASP n 1 479 ASN n 1 480 ALA n 1 481 LEU n 1 482 SER n 1 483 SER n 1 484 THR n 1 485 LEU n 1 486 PRO n 1 487 PRO n 1 488 GLY n 1 489 ILE n 1 490 GLY n 1 491 LEU n 1 492 LEU n 1 493 THR n 1 494 GLU n 1 495 LEU n 1 496 THR n 1 497 LYS n 1 498 LEU n 1 499 ASN n 1 500 LEU n 1 501 ALA n 1 502 LYS n 1 503 ASN n 1 504 ARG n 1 505 LEU n 1 506 SER n 1 507 GLY n 1 508 GLU n 1 509 ILE n 1 510 PRO n 1 511 ARG n 1 512 GLU n 1 513 ILE n 1 514 SER n 1 515 THR n 1 516 CYS n 1 517 ARG n 1 518 SER n 1 519 LEU n 1 520 GLN n 1 521 LEU n 1 522 LEU n 1 523 ASN n 1 524 LEU n 1 525 GLY n 1 526 GLU n 1 527 ASN n 1 528 ASP n 1 529 PHE n 1 530 SER n 1 531 GLY n 1 532 GLU n 1 533 ILE n 1 534 PRO n 1 535 ASP n 1 536 GLU n 1 537 LEU n 1 538 GLY n 1 539 GLN n 1 540 ILE n 1 541 PRO n 1 542 SER n 1 543 LEU n 1 544 ALA n 1 545 ILE n 1 546 SER n 1 547 LEU n 1 548 ASN n 1 549 LEU n 1 550 SER n 1 551 CYS n 1 552 ASN n 1 553 ARG n 1 554 PHE n 1 555 VAL n 1 556 GLY n 1 557 GLU n 1 558 ILE n 1 559 PRO n 1 560 SER n 1 561 ARG n 1 562 PHE n 1 563 SER n 1 564 ASP n 1 565 LEU n 1 566 LYS n 1 567 ASN n 1 568 LEU n 1 569 GLY n 1 570 VAL n 1 571 LEU n 1 572 ASP n 1 573 VAL n 1 574 SER n 1 575 HIS n 1 576 ASN n 1 577 GLN n 1 578 LEU n 1 579 THR n 1 580 GLY n 1 581 ASN n 1 582 LEU n 1 583 ASN n 1 584 VAL n 1 585 LEU n 1 586 THR n 1 587 ASP n 1 588 LEU n 1 589 GLN n 1 590 ASN n 1 591 LEU n 1 592 VAL n 1 593 SER n 1 594 LEU n 1 595 ASN n 1 596 ILE n 1 597 SER n 1 598 TYR n 1 599 ASN n 1 600 ASP n 1 601 PHE n 1 602 SER n 1 603 GLY n 1 604 ASP n 1 605 LEU n 1 606 PRO n 1 607 ASN n 1 608 THR n 1 609 PRO n 1 610 PHE n 1 611 PHE n 1 612 ARG n 1 613 ARG n 1 614 LEU n 1 615 PRO n 1 616 LEU n 1 617 SER n 1 618 ASP n 1 619 LEU n 1 620 ALA n 1 621 SER n 1 622 ASN n 1 623 ARG n 1 624 GLY n 1 625 LEU n 1 626 TYR n 1 627 ILE n 1 628 SER n 1 629 ASN n 1 630 ALA n 1 631 ILE n 1 632 SER n 1 633 THR n 2 1 ASP n 2 2 PTR n 2 3 PRO n 2 4 LYS n 2 5 PRO n 2 6 SER n 2 7 THR n 2 8 ARG n 2 9 PRO n 2 10 HZP n 2 11 ARG n 2 12 HIS n 2 13 ASN n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type 'Biological sequence' _entity_src_gen.pdbx_beg_seq_num 1 _entity_src_gen.pdbx_end_seq_num 633 _entity_src_gen.gene_src_common_name 'Mouse-ear cress' _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene 'At4g26540, M3E9.30' _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Arabidopsis thaliana' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 3702 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'Insect cell expression vector pTIE1' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 266783 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain ? _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type ? _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name ? _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _pdbx_entity_src_syn.entity_id 2 _pdbx_entity_src_syn.pdbx_src_id 1 _pdbx_entity_src_syn.pdbx_alt_source_flag sample _pdbx_entity_src_syn.pdbx_beg_seq_num 1 _pdbx_entity_src_syn.pdbx_end_seq_num 13 _pdbx_entity_src_syn.organism_scientific Arabidopsis _pdbx_entity_src_syn.organism_common_name ? _pdbx_entity_src_syn.ncbi_taxonomy_id 3701 _pdbx_entity_src_syn.details ? # loop_ _struct_ref.id _struct_ref.db_name _struct_ref.db_code _struct_ref.pdbx_db_accession _struct_ref.pdbx_db_isoform _struct_ref.entity_id _struct_ref.pdbx_seq_one_letter_code _struct_ref.pdbx_align_begin 1 UNP Y4265_ARATH C0LGR3 ? 1 ;CNWVGVKCNRRGEVSEIQLKGMDLQGSLPVTSLRSLKSLTSLTLSSLNLTGVIPKEIGDFTELELLDLSDNSLSGDIPVE IFRLKKLKTLSLNTNNLEGHIPMEIGNLSGLVELMLFDNKLSGEIPRSIGELKNLQVLRAGGNKNLRGELPWEIGNCENL VMLGLAETSLSGKLPASIGNLKRVQTIAIYTSLLSGPIPDEIGYCTELQNLYLYQNSISGSIPTTIGGLKKLQSLLLWQN NLVGKIPTELGNCPELWLIDFSENLLTGTIPRSFGKLENLQELQLSVNQISGTIPEELTNCTKLTHLEIDNNLITGEIPS LMSNLRSLTMFFAWQNKLTGNIPQSLSQCRELQAIDLSYNSLSGSIPKEIFGLRNLTKLLLLSNDLSGFIPPDIGNCTNL YRLRLNGNRLAGSIPSEIGNLKNLNFVDISENRLVGSIPPAISGCESLEFLDLHTNSLSGSLLGTTLPKSLKFIDFSDNA LSSTLPPGIGLLTELTKLNLAKNRLSGEIPREISTCRSLQLLNLGENDFSGEIPDELGQIPSLAISLNLSCNRFVGEIPS RFSDLKNLGVLDVSHNQLTGNLNVLTDLQNLVSLNISYNDFSGDLPNTPFFRRLPLSDLASNRGLYISNAIST ; 57 2 PDB 5HZ3 5HZ3 ? 2 ? 1 # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 5HZ3 B 1 ? 633 ? C0LGR3 57 ? 689 ? 61 689 2 2 5HZ3 A 1 ? 13 ? 5HZ3 44 ? 56 ? 44 56 # loop_ _struct_ref_seq_dif.align_id _struct_ref_seq_dif.pdbx_pdb_id_code _struct_ref_seq_dif.mon_id _struct_ref_seq_dif.pdbx_pdb_strand_id _struct_ref_seq_dif.seq_num _struct_ref_seq_dif.pdbx_pdb_ins_code _struct_ref_seq_dif.pdbx_seq_db_name _struct_ref_seq_dif.pdbx_seq_db_accession_code _struct_ref_seq_dif.db_mon_id _struct_ref_seq_dif.pdbx_seq_db_seq_num _struct_ref_seq_dif.details _struct_ref_seq_dif.pdbx_auth_seq_num _struct_ref_seq_dif.pdbx_ordinal 1 5HZ3 THR B 4 ? UNP C0LGR3 VAL 60 'engineered mutation' 64 1 1 5HZ3 GLU B 21 ? UNP C0LGR3 GLY 77 'engineered mutation' 81 2 1 5HZ3 LYS B 22 ? UNP C0LGR3 MET 78 'engineered mutation' 82 3 1 5HZ3 GLN B 23 ? UNP C0LGR3 ASP 79 'engineered mutation' 83 4 1 5HZ3 GLN B 48 ? UNP C0LGR3 ASN 104 'engineered mutation' 104 5 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HZP 'L-peptide linking' n '(4S)-4-hydroxy-L-proline' ? 'C5 H9 N O3' 131.130 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 PTR 'L-peptide linking' n O-PHOSPHOTYROSINE PHOSPHONOTYROSINE 'C9 H12 N O6 P' 261.168 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.absorpt_coefficient_mu ? _exptl.absorpt_correction_T_max ? _exptl.absorpt_correction_T_min ? _exptl.absorpt_correction_type ? _exptl.absorpt_process_details ? _exptl.entry_id 5HZ3 _exptl.crystals_number 1 _exptl.details ? _exptl.method 'X-RAY DIFFRACTION' _exptl.method_details ? # _exptl_crystal.colour ? _exptl_crystal.density_diffrn ? _exptl_crystal.density_Matthews 3.85 _exptl_crystal.density_method ? _exptl_crystal.density_percent_sol 68.08 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.id 1 _exptl_crystal.preparation ? _exptl_crystal.size_max ? _exptl_crystal.size_mid ? _exptl_crystal.size_min ? _exptl_crystal.size_rad ? _exptl_crystal.colour_lustre ? _exptl_crystal.colour_modifier ? _exptl_crystal.colour_primary ? _exptl_crystal.density_meas ? _exptl_crystal.density_meas_esd ? _exptl_crystal.density_meas_gt ? _exptl_crystal.density_meas_lt ? _exptl_crystal.density_meas_temp ? _exptl_crystal.density_meas_temp_esd ? _exptl_crystal.density_meas_temp_gt ? _exptl_crystal.density_meas_temp_lt ? _exptl_crystal.pdbx_crystal_image_url ? _exptl_crystal.pdbx_crystal_image_format ? _exptl_crystal.pdbx_mosaicity ? _exptl_crystal.pdbx_mosaicity_esd ? # _exptl_crystal_grow.apparatus ? _exptl_crystal_grow.atmosphere ? _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.details ? _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.method_ref ? _exptl_crystal_grow.pH ? _exptl_crystal_grow.pressure ? _exptl_crystal_grow.pressure_esd ? _exptl_crystal_grow.seeding ? _exptl_crystal_grow.seeding_ref ? _exptl_crystal_grow.temp 293 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.temp_esd ? _exptl_crystal_grow.time ? _exptl_crystal_grow.pdbx_details '0.1 M MES monohydrate pH 6.0, 22% (v/v) polyethylene glycol (PEG) 400.' _exptl_crystal_grow.pdbx_pH_range ? # _diffrn.ambient_environment ? _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.ambient_temp_esd ? _diffrn.crystal_id 1 _diffrn.crystal_support ? _diffrn.crystal_treatment ? _diffrn.details ? _diffrn.id 1 _diffrn.ambient_pressure ? _diffrn.ambient_pressure_esd ? _diffrn.ambient_pressure_gt ? _diffrn.ambient_pressure_lt ? _diffrn.ambient_temp_gt ? _diffrn.ambient_temp_lt ? # _diffrn_detector.details ? _diffrn_detector.detector CCD _diffrn_detector.diffrn_id 1 _diffrn_detector.type 'OXFORD RUBY CCD' _diffrn_detector.area_resol_mean ? _diffrn_detector.dtime ? _diffrn_detector.pdbx_frames_total ? _diffrn_detector.pdbx_collection_time_total ? _diffrn_detector.pdbx_collection_date 2014-12-21 # _diffrn_radiation.collimation ? _diffrn_radiation.diffrn_id 1 _diffrn_radiation.filter_edge ? _diffrn_radiation.inhomogeneity ? _diffrn_radiation.monochromator ? _diffrn_radiation.polarisn_norm ? _diffrn_radiation.polarisn_ratio ? _diffrn_radiation.probe ? _diffrn_radiation.type ? _diffrn_radiation.xray_symbol ? _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.pdbx_wavelength_list ? _diffrn_radiation.pdbx_wavelength ? _diffrn_radiation.pdbx_diffrn_protocol LAUE _diffrn_radiation.pdbx_analyzer ? _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 1 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.current ? _diffrn_source.details ? _diffrn_source.diffrn_id 1 _diffrn_source.power ? _diffrn_source.size ? _diffrn_source.source SYNCHROTRON _diffrn_source.target ? _diffrn_source.type 'SSRF BEAMLINE BL17U' _diffrn_source.voltage ? _diffrn_source.take-off_angle ? _diffrn_source.pdbx_wavelength_list 1 _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_synchrotron_beamline BL17U _diffrn_source.pdbx_synchrotron_site SSRF # _reflns.entry_id 5HZ3 _reflns.pdbx_diffrn_id 1 _reflns.pdbx_ordinal 1 _reflns.observed_criterion_sigma_I ? _reflns.observed_criterion_sigma_F ? _reflns.d_resolution_low 99.000 _reflns.d_resolution_high 2.860 _reflns.number_obs 22741 _reflns.number_all ? _reflns.percent_possible_obs 93.0 _reflns.pdbx_Rmerge_I_obs ? _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI 13.4000 _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy 5.30 _reflns.pdbx_Rrim_I_all ? _reflns.pdbx_Rpim_I_all ? _reflns.pdbx_CC_half ? _reflns.pdbx_netI_over_av_sigmaI ? _reflns.pdbx_number_measured_all ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_chi_squared ? _reflns.Rmerge_F_all ? _reflns.Rmerge_F_obs ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.observed_criterion_I_max ? _reflns.observed_criterion_I_min ? _reflns.pdbx_d_res_high_opt ? _reflns.pdbx_d_res_low_opt ? _reflns.details ? # _reflns_shell.d_res_high . _reflns_shell.d_res_low ? _reflns_shell.meanI_over_sigI_all ? _reflns_shell.meanI_over_sigI_obs ? _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_possible ? _reflns_shell.number_unique_all ? _reflns_shell.number_unique_obs ? _reflns_shell.percent_possible_all ? _reflns_shell.percent_possible_obs ? _reflns_shell.Rmerge_F_all ? _reflns_shell.Rmerge_F_obs ? _reflns_shell.Rmerge_I_all ? _reflns_shell.Rmerge_I_obs ? _reflns_shell.meanI_over_sigI_gt ? _reflns_shell.meanI_over_uI_all ? _reflns_shell.meanI_over_uI_gt ? _reflns_shell.number_measured_gt ? _reflns_shell.number_unique_gt ? _reflns_shell.percent_possible_gt ? _reflns_shell.Rmerge_F_gt ? _reflns_shell.Rmerge_I_gt ? _reflns_shell.pdbx_redundancy ? _reflns_shell.pdbx_Rsym_value ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_netI_over_sigmaI_all ? _reflns_shell.pdbx_netI_over_sigmaI_obs ? _reflns_shell.pdbx_Rrim_I_all ? _reflns_shell.pdbx_Rpim_I_all ? _reflns_shell.pdbx_rejects ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 _reflns_shell.pdbx_CC_half ? _reflns_shell.pdbx_R_split ? # _refine.entry_id 5HZ3 _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.ls_d_res_high 2.8600 _refine.ls_d_res_low 29.8800 _refine.pdbx_ls_sigma_F 0.000 _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.ls_percent_reflns_obs 93.0600 _refine.ls_number_reflns_obs 22725 _refine.ls_number_reflns_all ? _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.ls_matrix_type ? _refine.pdbx_R_Free_selection_details ? _refine.details 'U VALUES : REFINED INDIVIDUALLY' _refine.ls_R_factor_all ? _refine.ls_R_factor_obs 0.2431 _refine.ls_R_factor_R_work 0.2431 _refine.ls_wR_factor_R_work ? _refine.ls_R_factor_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_percent_reflns_R_free ? _refine.ls_number_reflns_R_free ? _refine.ls_number_reflns_R_work ? _refine.ls_R_factor_R_free_error ? _refine.B_iso_mean 26.2220 _refine.solvent_model_param_bsol ? _refine.solvent_model_param_ksol ? _refine.pdbx_isotropic_thermal_model ? _refine.aniso_B[1][1] 2.4400 _refine.aniso_B[2][2] 2.4400 _refine.aniso_B[3][3] -7.9100 _refine.aniso_B[1][2] 2.4400 _refine.aniso_B[1][3] 0.0000 _refine.aniso_B[2][3] -0.0000 _refine.correlation_coeff_Fo_to_Fc 0.9040 _refine.correlation_coeff_Fo_to_Fc_free ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? _refine.overall_SU_R_free ? _refine.pdbx_overall_ESU_R 0.9250 _refine.pdbx_overall_ESU_R_Free ? _refine.overall_SU_ML ? _refine.overall_SU_B ? _refine.solvent_model_details MASK _refine.pdbx_solvent_vdw_probe_radii 1.2000 _refine.pdbx_solvent_ion_probe_radii 0.8000 _refine.pdbx_solvent_shrinkage_radii 0.8000 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.pdbx_starting_model ? _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_stereochem_target_val_spec_case ? _refine.overall_FOM_work_R_set ? _refine.B_iso_max 134.430 _refine.B_iso_min 2.000 _refine.pdbx_overall_phase_error ? _refine.occupancy_max ? _refine.occupancy_min ? _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_ls_sigma_I ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_R_factor_R_free_error_details ? # _refine_hist.cycle_id final _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.d_res_high 2.8600 _refine_hist.d_res_low 29.8800 _refine_hist.pdbx_number_atoms_ligand 56 _refine_hist.number_atoms_solvent 0 _refine_hist.number_atoms_total 4948 _refine_hist.pdbx_number_residues_total 638 _refine_hist.pdbx_B_iso_mean_ligand 28.98 _refine_hist.pdbx_number_atoms_protein 4892 _refine_hist.pdbx_number_atoms_nucleic_acid 0 # _refine_ls_shell.d_res_high 2.8610 _refine_ls_shell.d_res_low 2.9350 _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.percent_reflns_obs 99.9400 _refine_ls_shell.number_reflns_R_work 1783 _refine_ls_shell.R_factor_all ? _refine_ls_shell.R_factor_R_work 0.2830 _refine_ls_shell.R_factor_R_free ? _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.number_reflns_R_free ? _refine_ls_shell.R_factor_R_free_error 0.0000 _refine_ls_shell.number_reflns_all ? _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_ls_shell.R_factor_obs ? # _struct.entry_id 5HZ3 _struct.title 'Plant peptide hormone receptor RGFR1 in complex with RGFR5' _struct.pdbx_descriptor ;ASP-PTR-PRO-LYS-PRO-SER-THR-ARG-PRO-HYP-ARG-HIS-ASN, Probable LRR receptor-like serine/threonine-protein kinase At4g26540 (E.C.2.7.11.1) ; _struct.pdbx_model_details ? _struct.pdbx_formula_weight ? _struct.pdbx_formula_weight_method ? _struct.pdbx_model_type_details ? _struct.pdbx_CASP_flag ? # _struct_keywords.entry_id 5HZ3 _struct_keywords.text 'Plant Receptor, TRANSFERASE' _struct_keywords.pdbx_keywords TRANSFERASE # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 3 ? D N N 3 ? E N N 3 ? F N N 3 ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 AA1 PRO A 54 ? PHE A 60 ? PRO B 110 PHE B 116 5 ? 7 HELX_P HELX_P2 AA2 PRO A 78 ? LEU A 84 ? PRO B 134 LEU B 140 5 ? 7 HELX_P HELX_P3 AA3 PRO A 102 ? LEU A 108 ? PRO B 158 LEU B 164 5 ? 7 HELX_P HELX_P4 AA4 PRO A 126 ? LEU A 132 ? PRO B 182 LEU B 188 5 ? 7 HELX_P HELX_P5 AA5 PRO A 151 ? CYS A 157 ? PRO B 207 CYS B 213 5 ? 7 HELX_P HELX_P6 AA6 PRO A 175 ? LEU A 181 ? PRO B 231 LEU B 237 5 ? 7 HELX_P HELX_P7 AA7 PRO A 199 ? CYS A 205 ? PRO B 255 CYS B 261 5 ? 7 HELX_P HELX_P8 AA8 PRO A 223 ? LEU A 229 ? PRO B 279 LEU B 285 5 ? 7 HELX_P HELX_P9 AA9 PRO A 247 ? CYS A 253 ? PRO B 303 CYS B 309 5 ? 7 HELX_P HELX_P10 AB1 PRO A 271 ? LEU A 277 ? PRO B 327 LEU B 333 5 ? 7 HELX_P HELX_P11 AB2 PRO A 295 ? CYS A 301 ? PRO B 351 CYS B 357 5 ? 7 HELX_P HELX_P12 AB3 PRO A 319 ? LEU A 325 ? PRO B 375 LEU B 381 5 ? 7 HELX_P HELX_P13 AB4 PRO A 343 ? CYS A 349 ? PRO B 399 CYS B 405 5 ? 7 HELX_P HELX_P14 AB5 PRO A 367 ? LEU A 373 ? PRO B 423 LEU B 429 5 ? 7 HELX_P HELX_P15 AB6 PRO A 391 ? CYS A 397 ? PRO B 447 CYS B 453 5 ? 7 HELX_P HELX_P16 AB7 PRO A 415 ? LEU A 421 ? PRO B 471 LEU B 477 5 ? 7 HELX_P HELX_P17 AB8 PRO A 439 ? CYS A 445 ? PRO B 495 CYS B 501 5 ? 7 HELX_P HELX_P18 AB9 LEU A 463 ? LEU A 467 ? LEU B 519 LEU B 523 5 ? 5 HELX_P HELX_P19 AC1 PRO A 486 ? LEU A 492 ? PRO B 542 LEU B 548 5 ? 7 HELX_P HELX_P20 AC2 PRO A 510 ? CYS A 516 ? PRO B 566 CYS B 572 5 ? 7 HELX_P HELX_P21 AC3 PRO A 534 ? ILE A 540 ? PRO B 590 ILE B 596 5 ? 7 HELX_P HELX_P22 AC4 PRO A 559 ? LEU A 565 ? PRO B 615 LEU B 621 5 ? 7 HELX_P HELX_P23 AC5 LEU A 582 ? THR A 586 ? LEU B 638 THR B 642 5 ? 5 HELX_P HELX_P24 AC6 PRO A 615 ? SER A 621 ? PRO B 671 SER B 677 1 ? 7 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order covale1 covale one ? A ASN 396 ND2 ? ? ? 1_555 C NAG . C1 ? ? B ASN 452 B NAG 701 1_555 ? ? ? ? ? ? ? 1.444 ? covale2 covale one ? A ASN 548 ND2 ? ? ? 1_555 E NAG . C1 ? ? B ASN 604 B NAG 703 1_555 ? ? ? ? ? ? ? 1.441 ? covale3 covale one ? A ASN 595 ND2 ? ? ? 1_555 F NAG . C1 ? ? B ASN 651 B NAG 704 1_555 ? ? ? ? ? ? ? 1.448 ? covale4 covale both ? B ASP 1 C ? ? ? 1_555 B PTR 2 N ? ? A ASP 44 A PTR 45 1_555 ? ? ? ? ? ? ? 1.330 ? covale5 covale both ? B PTR 2 C ? ? ? 1_555 B PRO 3 N ? ? A PTR 45 A PRO 46 1_555 ? ? ? ? ? ? ? 1.341 ? covale6 covale both ? B PRO 9 C ? ? ? 1_555 B HZP 10 N ? ? A PRO 52 A HZP 53 1_555 ? ? ? ? ? ? ? 1.333 ? covale7 covale both ? B HZP 10 C ? ? ? 1_555 B ARG 11 N ? ? A HZP 53 A ARG 54 1_555 ? ? ? ? ? ? ? 1.329 ? covale8 covale both ? C NAG . O4 ? ? ? 1_555 D NAG . C1 ? ? B NAG 701 B NAG 702 1_555 ? ? ? ? ? ? ? 1.458 ? # _struct_conn_type.id covale _struct_conn_type.criteria ? _struct_conn_type.reference ? # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details AA1 ? 26 ? AA2 ? 2 ? AA3 ? 2 ? AA4 ? 2 ? AA5 ? 2 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense AA1 1 2 ? anti-parallel AA1 2 3 ? parallel AA1 3 4 ? parallel AA1 4 5 ? parallel AA1 5 6 ? parallel AA1 6 7 ? parallel AA1 7 8 ? parallel AA1 8 9 ? parallel AA1 9 10 ? parallel AA1 10 11 ? parallel AA1 11 12 ? parallel AA1 12 13 ? parallel AA1 13 14 ? parallel AA1 14 15 ? parallel AA1 15 16 ? parallel AA1 16 17 ? parallel AA1 17 18 ? parallel AA1 18 19 ? parallel AA1 19 20 ? parallel AA1 20 21 ? parallel AA1 21 22 ? parallel AA1 22 23 ? parallel AA1 23 24 ? parallel AA1 24 25 ? parallel AA1 25 26 ? parallel AA2 1 2 ? parallel AA3 1 2 ? parallel AA4 1 2 ? parallel AA5 1 2 ? parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id AA1 1 VAL A 6 ? CYS A 8 ? VAL B 66 CYS B 68 AA1 2 VAL A 14 ? LYS A 20 ? VAL B 74 LYS B 80 AA1 3 SER A 41 ? SER A 45 ? SER B 97 SER B 101 AA1 4 LEU A 65 ? ASP A 67 ? LEU B 121 ASP B 123 AA1 5 THR A 89 ? SER A 91 ? THR B 145 SER B 147 AA1 6 GLU A 113 ? MET A 115 ? GLU B 169 MET B 171 AA1 7 VAL A 137 ? ARG A 139 ? VAL B 193 ARG B 195 AA1 8 MET A 162 ? GLY A 164 ? MET B 218 GLY B 220 AA1 9 THR A 186 ? ALA A 188 ? THR B 242 ALA B 244 AA1 10 ASN A 210 ? TYR A 212 ? ASN B 266 TYR B 268 AA1 11 SER A 234 ? LEU A 236 ? SER B 290 LEU B 292 AA1 12 LEU A 258 ? ASP A 260 ? LEU B 314 ASP B 316 AA1 13 GLU A 282 ? GLN A 284 ? GLU B 338 GLN B 340 AA1 14 HIS A 306 ? GLU A 308 ? HIS B 362 GLU B 364 AA1 15 MET A 330 ? PHE A 332 ? MET B 386 PHE B 388 AA1 16 ALA A 354 ? ASP A 356 ? ALA B 410 ASP B 412 AA1 17 LYS A 378 ? LEU A 380 ? LYS B 434 LEU B 436 AA1 18 ARG A 402 ? ARG A 404 ? ARG B 458 ARG B 460 AA1 19 PHE A 426 ? ASP A 428 ? PHE B 482 ASP B 484 AA1 20 PHE A 450 ? ASP A 452 ? PHE B 506 ASP B 508 AA1 21 PHE A 473 ? ASP A 475 ? PHE B 529 ASP B 531 AA1 22 LYS A 497 ? ASN A 499 ? LYS B 553 ASN B 555 AA1 23 LEU A 521 ? ASN A 523 ? LEU B 577 ASN B 579 AA1 24 SER A 546 ? ASN A 548 ? SER B 602 ASN B 604 AA1 25 VAL A 570 ? ASP A 572 ? VAL B 626 ASP B 628 AA1 26 SER A 593 ? ASN A 595 ? SER B 649 ASN B 651 AA2 1 SER A 122 ? GLU A 124 ? SER B 178 GLU B 180 AA2 2 ASN A 145 ? ARG A 147 ? ASN B 201 ARG B 203 AA3 1 SER A 171 ? GLY A 172 ? SER B 227 GLY B 228 AA3 2 LEU A 193 ? LEU A 194 ? LEU B 249 LEU B 250 AA4 1 SER A 506 ? GLY A 507 ? SER B 562 GLY B 563 AA4 2 ASP A 528 ? PHE A 529 ? ASP B 584 PHE B 585 AA5 1 SER A 602 ? LEU A 605 ? SER B 658 LEU B 661 AA5 2 GLY A 624 ? ILE A 627 ? GLY B 680 ILE B 683 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id AA1 1 2 N LYS A 7 ? N LYS B 67 O SER A 15 ? O SER B 75 AA1 2 3 N ILE A 17 ? N ILE B 77 O SER A 41 ? O SER B 97 AA1 3 4 N LEU A 42 ? N LEU B 98 O ASP A 67 ? O ASP B 123 AA1 4 5 N LEU A 66 ? N LEU B 122 O SER A 91 ? O SER B 147 AA1 5 6 N LEU A 90 ? N LEU B 146 O MET A 115 ? O MET B 171 AA1 6 7 N LEU A 114 ? N LEU B 170 O VAL A 137 ? O VAL B 193 AA1 7 8 N LEU A 138 ? N LEU B 194 O MET A 162 ? O MET B 218 AA1 8 9 N LEU A 163 ? N LEU B 219 O ALA A 188 ? O ALA B 244 AA1 9 10 N ILE A 187 ? N ILE B 243 O TYR A 212 ? O TYR B 268 AA1 10 11 N LEU A 211 ? N LEU B 267 O SER A 234 ? O SER B 290 AA1 11 12 N LEU A 235 ? N LEU B 291 O ASP A 260 ? O ASP B 316 AA1 12 13 N ILE A 259 ? N ILE B 315 O GLN A 284 ? O GLN B 340 AA1 13 14 N LEU A 283 ? N LEU B 339 O HIS A 306 ? O HIS B 362 AA1 14 15 N LEU A 307 ? N LEU B 363 O MET A 330 ? O MET B 386 AA1 15 16 N PHE A 331 ? N PHE B 387 O ALA A 354 ? O ALA B 410 AA1 16 17 N ILE A 355 ? N ILE B 411 O LYS A 378 ? O LYS B 434 AA1 17 18 N LEU A 379 ? N LEU B 435 O ARG A 404 ? O ARG B 460 AA1 18 19 N LEU A 403 ? N LEU B 459 O PHE A 426 ? O PHE B 482 AA1 19 20 N VAL A 427 ? N VAL B 483 O PHE A 450 ? O PHE B 506 AA1 20 21 N LEU A 451 ? N LEU B 507 O PHE A 473 ? O PHE B 529 AA1 21 22 N ILE A 474 ? N ILE B 530 O ASN A 499 ? O ASN B 555 AA1 22 23 N LEU A 498 ? N LEU B 554 O ASN A 523 ? O ASN B 579 AA1 23 24 N LEU A 522 ? N LEU B 578 O ASN A 548 ? O ASN B 604 AA1 24 25 N LEU A 547 ? N LEU B 603 O ASP A 572 ? O ASP B 628 AA1 25 26 N LEU A 571 ? N LEU B 627 O SER A 593 ? O SER B 649 AA2 1 2 N GLY A 123 ? N GLY B 179 O ARG A 147 ? O ARG B 203 AA3 1 2 N GLY A 172 ? N GLY B 228 O LEU A 193 ? O LEU B 249 AA4 1 2 N GLY A 507 ? N GLY B 563 O ASP A 528 ? O ASP B 584 AA5 1 2 N LEU A 605 ? N LEU B 661 O TYR A 626 ? O TYR B 682 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software B ASN 452 ? 5 'binding site for Poly-Saccharide residues NAG B 701 through NAG B 702 bound to ASN B 452' AC2 Software B NAG 703 ? 5 'binding site for Mono-Saccharide NAG B 703 bound to ASN B 604' AC3 Software B NAG 704 ? 6 'binding site for Mono-Saccharide NAG B 704 bound to ASN B 651' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 5 ARG A 83 ? ARG B 139 . ? 8_544 ? 2 AC1 5 LYS A 368 ? LYS B 424 . ? 1_555 ? 3 AC1 5 GLY A 372 ? GLY B 428 . ? 1_555 ? 4 AC1 5 ASP A 393 ? ASP B 449 . ? 1_555 ? 5 AC1 5 ASN A 396 ? ASN B 452 . ? 1_555 ? 6 AC2 5 GLU A 526 ? GLU B 582 . ? 1_555 ? 7 AC2 5 ASN A 548 ? ASN B 604 . ? 1_555 ? 8 AC2 5 SER A 550 ? SER B 606 . ? 1_555 ? 9 AC2 5 ASP A 572 ? ASP B 628 . ? 1_555 ? 10 AC2 5 NAG F . ? NAG B 704 . ? 1_555 ? 11 AC3 6 SER A 550 ? SER B 606 . ? 1_555 ? 12 AC3 6 ASP A 572 ? ASP B 628 . ? 1_555 ? 13 AC3 6 SER A 574 ? SER B 630 . ? 1_555 ? 14 AC3 6 SER A 593 ? SER B 649 . ? 1_555 ? 15 AC3 6 ASN A 595 ? ASN B 651 . ? 1_555 ? 16 AC3 6 NAG E . ? NAG B 703 . ? 1_555 ? # _atom_sites.entry_id 5HZ3 _atom_sites.fract_transf_matrix[1][1] 0.005581 _atom_sites.fract_transf_matrix[1][2] 0.003222 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] -0.000000 _atom_sites.fract_transf_matrix[2][2] 0.006445 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] -0.000000 _atom_sites.fract_transf_matrix[3][3] 0.011312 _atom_sites.fract_transf_vector[1] 0.000000 _atom_sites.fract_transf_vector[2] 0.000000 _atom_sites.fract_transf_vector[3] 0.000000 # loop_ _atom_type.symbol C N O P S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . CYS A 1 1 ? 71.065 37.749 -36.775 1.00 50.90 ? 61 CYS B N 1 ATOM 2 C CA . CYS A 1 1 ? 69.916 37.430 -35.930 1.00 70.97 ? 61 CYS B CA 1 ATOM 3 C C . CYS A 1 1 ? 68.868 36.595 -36.674 1.00 68.40 ? 61 CYS B C 1 ATOM 4 O O . CYS A 1 1 ? 67.665 36.739 -36.453 1.00 58.73 ? 61 CYS B O 1 ATOM 5 C CB . CYS A 1 1 ? 69.281 38.709 -35.376 1.00 71.32 ? 61 CYS B CB 1 ATOM 6 N N . ASN A 1 2 ? 69.345 35.731 -37.564 1.00 78.84 ? 62 ASN B N 1 ATOM 7 C CA . ASN A 1 2 ? 68.493 34.822 -38.328 1.00 80.46 ? 62 ASN B CA 1 ATOM 8 C C . ASN A 1 2 ? 68.374 33.443 -37.681 1.00 86.07 ? 62 ASN B C 1 ATOM 9 O O . ASN A 1 2 ? 67.808 32.524 -38.279 1.00 89.15 ? 62 ASN B O 1 ATOM 10 C CB . ASN A 1 2 ? 68.996 34.685 -39.768 1.00 77.15 ? 62 ASN B CB 1 ATOM 11 N N . TRP A 1 3 ? 68.922 33.304 -36.473 1.00 84.08 ? 63 TRP B N 1 ATOM 12 C CA . TRP A 1 3 ? 69.000 32.014 -35.786 1.00 87.27 ? 63 TRP B CA 1 ATOM 13 C C . TRP A 1 3 ? 67.639 31.310 -35.662 1.00 83.90 ? 63 TRP B C 1 ATOM 14 O O . TRP A 1 3 ? 66.595 31.960 -35.576 1.00 82.72 ? 63 TRP B O 1 ATOM 15 C CB . TRP A 1 3 ? 69.629 32.181 -34.394 1.00 95.26 ? 63 TRP B CB 1 ATOM 16 C CG . TRP A 1 3 ? 71.099 32.523 -34.404 1.00 104.60 ? 63 TRP B CG 1 ATOM 17 C CD1 . TRP A 1 3 ? 71.674 33.700 -34.011 1.00 108.02 ? 63 TRP B CD1 1 ATOM 18 C CD2 . TRP A 1 3 ? 72.175 31.673 -34.824 1.00 108.15 ? 63 TRP B CD2 1 ATOM 19 N NE1 . TRP A 1 3 ? 73.040 33.634 -34.161 1.00 110.48 ? 63 TRP B NE1 1 ATOM 20 C CE2 . TRP A 1 3 ? 73.372 32.402 -34.660 1.00 111.30 ? 63 TRP B CE2 1 ATOM 21 C CE3 . TRP A 1 3 ? 72.242 30.369 -35.324 1.00 105.58 ? 63 TRP B CE3 1 ATOM 22 C CZ2 . TRP A 1 3 ? 74.618 31.868 -34.978 1.00 112.85 ? 63 TRP B CZ2 1 ATOM 23 C CZ3 . TRP A 1 3 ? 73.478 29.842 -35.638 1.00 106.57 ? 63 TRP B CZ3 1 ATOM 24 C CH2 . TRP A 1 3 ? 74.650 30.590 -35.466 1.00 110.89 ? 63 TRP B CH2 1 ATOM 25 N N . THR A 1 4 ? 67.661 29.979 -35.683 1.00 79.04 ? 64 THR B N 1 ATOM 26 C CA . THR A 1 4 ? 66.443 29.182 -35.568 1.00 66.82 ? 64 THR B CA 1 ATOM 27 C C . THR A 1 4 ? 65.850 29.326 -34.172 1.00 64.40 ? 64 THR B C 1 ATOM 28 O O . THR A 1 4 ? 66.532 29.091 -33.174 1.00 65.73 ? 64 THR B O 1 ATOM 29 C CB . THR A 1 4 ? 66.717 27.690 -35.843 1.00 58.96 ? 64 THR B CB 1 ATOM 30 N N . GLY A 1 5 ? 64.579 29.712 -34.107 1.00 59.80 ? 65 GLY B N 1 ATOM 31 C CA . GLY A 1 5 ? 63.927 30.000 -32.842 1.00 55.76 ? 65 GLY B CA 1 ATOM 32 C C . GLY A 1 5 ? 63.757 31.491 -32.589 1.00 51.16 ? 65 GLY B C 1 ATOM 33 O O . GLY A 1 5 ? 63.202 31.902 -31.569 1.00 44.54 ? 65 GLY B O 1 ATOM 34 N N . VAL A 1 6 ? 64.232 32.308 -33.523 1.00 53.25 ? 66 VAL B N 1 ATOM 35 C CA . VAL A 1 6 ? 64.105 33.757 -33.400 1.00 54.79 ? 66 VAL B CA 1 ATOM 36 C C . VAL A 1 6 ? 63.317 34.331 -34.583 1.00 56.91 ? 66 VAL B C 1 ATOM 37 O O . VAL A 1 6 ? 63.525 33.942 -35.728 1.00 51.19 ? 66 VAL B O 1 ATOM 38 C CB . VAL A 1 6 ? 65.491 34.452 -33.290 1.00 46.73 ? 66 VAL B CB 1 ATOM 39 C CG1 . VAL A 1 6 ? 65.327 35.949 -33.094 1.00 46.85 ? 66 VAL B CG1 1 ATOM 40 C CG2 . VAL A 1 6 ? 66.311 33.858 -32.148 1.00 42.01 ? 66 VAL B CG2 1 ATOM 41 N N . LYS A 1 7 ? 62.394 35.240 -34.287 1.00 61.90 ? 67 LYS B N 1 ATOM 42 C CA . LYS A 1 7 ? 61.605 35.918 -35.306 1.00 59.25 ? 67 LYS B CA 1 ATOM 43 C C . LYS A 1 7 ? 61.835 37.425 -35.195 1.00 60.12 ? 67 LYS B C 1 ATOM 44 O O . LYS A 1 7 ? 61.623 38.009 -34.142 1.00 58.24 ? 67 LYS B O 1 ATOM 45 C CB . LYS A 1 7 ? 60.111 35.606 -35.132 1.00 60.03 ? 67 LYS B CB 1 ATOM 46 C CG . LYS A 1 7 ? 59.730 34.138 -35.311 1.00 62.42 ? 67 LYS B CG 1 ATOM 47 C CD . LYS A 1 7 ? 58.208 33.943 -35.340 1.00 66.16 ? 67 LYS B CD 1 ATOM 48 C CE . LYS A 1 7 ? 57.547 34.822 -36.407 1.00 72.41 ? 67 LYS B CE 1 ATOM 49 N NZ . LYS A 1 7 ? 56.689 34.063 -37.368 1.00 70.77 ? 67 LYS B NZ 1 ATOM 50 N N . CYS A 1 8 ? 62.279 38.059 -36.272 1.00 67.69 ? 68 CYS B N 1 ATOM 51 C CA . CYS A 1 8 ? 62.497 39.501 -36.247 1.00 71.85 ? 68 CYS B CA 1 ATOM 52 C C . CYS A 1 8 ? 61.279 40.253 -36.780 1.00 70.34 ? 68 CYS B C 1 ATOM 53 O O . CYS A 1 8 ? 60.629 39.797 -37.720 1.00 69.11 ? 68 CYS B O 1 ATOM 54 C CB . CYS A 1 8 ? 63.752 39.872 -37.041 1.00 73.96 ? 68 CYS B CB 1 ATOM 55 S SG . CYS A 1 8 ? 65.305 39.752 -36.109 1.00 74.63 ? 68 CYS B SG 1 ATOM 56 N N . ASN A 1 9 ? 60.962 41.390 -36.159 1.00 69.31 ? 69 ASN B N 1 ATOM 57 C CA . ASN A 1 9 ? 59.859 42.239 -36.613 1.00 69.46 ? 69 ASN B CA 1 ATOM 58 C C . ASN A 1 9 ? 60.204 42.898 -37.946 1.00 79.06 ? 69 ASN B C 1 ATOM 59 O O . ASN A 1 9 ? 61.377 42.942 -38.323 1.00 88.27 ? 69 ASN B O 1 ATOM 60 C CB . ASN A 1 9 ? 59.442 43.271 -35.541 1.00 63.89 ? 69 ASN B CB 1 ATOM 61 C CG . ASN A 1 9 ? 60.497 44.352 -35.288 1.00 71.29 ? 69 ASN B CG 1 ATOM 62 O OD1 . ASN A 1 9 ? 61.622 44.281 -35.779 1.00 80.45 ? 69 ASN B OD1 1 ATOM 63 N ND2 . ASN A 1 9 ? 60.123 45.362 -34.503 1.00 68.54 ? 69 ASN B ND2 1 ATOM 64 N N . ARG A 1 10 ? 59.195 43.379 -38.674 1.00 76.60 ? 70 ARG B N 1 ATOM 65 C CA . ARG A 1 10 ? 59.453 44.024 -39.966 1.00 78.96 ? 70 ARG B CA 1 ATOM 66 C C . ARG A 1 10 ? 60.242 45.339 -39.851 1.00 78.15 ? 70 ARG B C 1 ATOM 67 O O . ARG A 1 10 ? 60.634 45.905 -40.878 1.00 75.80 ? 70 ARG B O 1 ATOM 68 C CB . ARG A 1 10 ? 58.167 44.274 -40.769 1.00 82.59 ? 70 ARG B CB 1 ATOM 69 C CG . ARG A 1 10 ? 57.269 45.352 -40.205 1.00 83.35 ? 70 ARG B CG 1 ATOM 70 C CD . ARG A 1 10 ? 56.364 45.973 -41.268 1.00 81.06 ? 70 ARG B CD 1 ATOM 71 N NE . ARG A 1 10 ? 55.918 45.000 -42.261 1.00 80.64 ? 70 ARG B NE 1 ATOM 72 C CZ . ARG A 1 10 ? 55.652 45.295 -43.532 1.00 81.11 ? 70 ARG B CZ 1 ATOM 73 N NH1 . ARG A 1 10 ? 55.780 46.544 -43.968 1.00 80.98 ? 70 ARG B NH1 1 ATOM 74 N NH2 . ARG A 1 10 ? 55.259 44.342 -44.370 1.00 77.29 ? 70 ARG B NH2 1 ATOM 75 N N . ARG A 1 11 ? 60.455 45.841 -38.626 1.00 75.18 ? 71 ARG B N 1 ATOM 76 C CA . ARG A 1 11 ? 61.412 46.950 -38.404 1.00 69.05 ? 71 ARG B CA 1 ATOM 77 C C . ARG A 1 11 ? 62.829 46.473 -38.003 1.00 68.18 ? 71 ARG B C 1 ATOM 78 O O . ARG A 1 11 ? 63.710 47.283 -37.703 1.00 70.22 ? 71 ARG B O 1 ATOM 79 C CB . ARG A 1 11 ? 60.866 48.103 -37.497 1.00 99.01 ? 71 ARG B CB 1 ATOM 80 C CG . ARG A 1 11 ? 61.115 48.162 -36.014 1.00 98.20 ? 71 ARG B CG 1 ATOM 81 C CD . ARG A 1 11 ? 60.887 49.567 -35.525 1.00 95.31 ? 71 ARG B CD 1 ATOM 82 N NE . ARG A 1 11 ? 59.563 49.746 -35.012 1.00 91.74 ? 71 ARG B NE 1 ATOM 83 C CZ . ARG A 1 11 ? 59.249 49.756 -33.725 1.00 87.75 ? 71 ARG B CZ 1 ATOM 84 N NH1 . ARG A 1 11 ? 60.183 49.592 -32.831 1.00 87.11 ? 71 ARG B NH1 1 ATOM 85 N NH2 . ARG A 1 11 ? 57.990 49.937 -33.314 1.00 84.30 ? 71 ARG B NH2 1 ATOM 86 N N . GLY A 1 12 ? 63.031 45.159 -37.948 1.00 66.51 ? 72 GLY B N 1 ATOM 87 C CA . GLY A 1 12 ? 64.368 44.606 -37.815 1.00 67.43 ? 72 GLY B CA 1 ATOM 88 C C . GLY A 1 12 ? 64.856 44.137 -36.456 1.00 71.47 ? 72 GLY B C 1 ATOM 89 O O . GLY A 1 12 ? 65.727 43.268 -36.418 1.00 74.47 ? 72 GLY B O 1 ATOM 90 N N . GLU A 1 13 ? 64.300 44.658 -35.358 1.00 72.51 ? 73 GLU B N 1 ATOM 91 C CA . GLU A 1 13 ? 64.659 44.163 -34.024 1.00 67.50 ? 73 GLU B CA 1 ATOM 92 C C . GLU A 1 13 ? 63.939 42.854 -33.676 1.00 63.17 ? 73 GLU B C 1 ATOM 93 O O . GLU A 1 13 ? 62.877 42.515 -34.214 1.00 42.72 ? 73 GLU B O 1 ATOM 94 C CB . GLU A 1 13 ? 64.455 45.194 -32.893 1.00 69.49 ? 73 GLU B CB 1 ATOM 95 C CG . GLU A 1 13 ? 64.977 46.580 -33.126 1.00 76.78 ? 73 GLU B CG 1 ATOM 96 C CD . GLU A 1 13 ? 63.889 47.484 -33.602 1.00 79.64 ? 73 GLU B CD 1 ATOM 97 O OE1 . GLU A 1 13 ? 62.665 47.215 -33.377 1.00 80.16 ? 73 GLU B OE1 1 ATOM 98 O OE2 . GLU A 1 13 ? 64.194 48.531 -34.238 1.00 79.55 ? 73 GLU B OE2 1 ATOM 99 N N . VAL A 1 14 ? 64.555 42.137 -32.751 1.00 62.53 ? 74 VAL B N 1 ATOM 100 C CA . VAL A 1 14 ? 64.017 40.921 -32.192 1.00 60.97 ? 74 VAL B CA 1 ATOM 101 C C . VAL A 1 14 ? 62.569 41.098 -31.748 1.00 59.25 ? 74 VAL B C 1 ATOM 102 O O . VAL A 1 14 ? 62.191 42.073 -31.090 1.00 62.27 ? 74 VAL B O 1 ATOM 103 C CB . VAL A 1 14 ? 64.870 40.500 -31.006 1.00 60.99 ? 74 VAL B CB 1 ATOM 104 C CG1 . VAL A 1 14 ? 64.480 39.124 -30.564 1.00 59.03 ? 74 VAL B CG1 1 ATOM 105 C CG2 . VAL A 1 14 ? 66.337 40.530 -31.413 1.00 60.71 ? 74 VAL B CG2 1 ATOM 106 N N . SER A 1 15 ? 61.766 40.137 -32.174 1.00 52.57 ? 75 SER B N 1 ATOM 107 C CA . SER A 1 15 ? 60.343 40.131 -31.935 1.00 46.60 ? 75 SER B CA 1 ATOM 108 C C . SER A 1 15 ? 59.999 38.942 -31.038 1.00 52.79 ? 75 SER B C 1 ATOM 109 O O . SER A 1 15 ? 59.443 39.126 -29.961 1.00 61.66 ? 75 SER B O 1 ATOM 110 C CB . SER A 1 15 ? 59.586 40.074 -33.262 1.00 41.35 ? 75 SER B CB 1 ATOM 111 O OG . SER A 1 15 ? 58.354 40.759 -33.176 1.00 40.79 ? 75 SER B OG 1 ATOM 112 N N . GLU A 1 16 ? 60.304 37.725 -31.489 1.00 48.06 ? 76 GLU B N 1 ATOM 113 C CA . GLU A 1 16 ? 59.941 36.517 -30.746 1.00 46.43 ? 76 GLU B CA 1 ATOM 114 C C . GLU A 1 16 ? 61.118 35.594 -30.404 1.00 48.63 ? 76 GLU B C 1 ATOM 115 O O . GLU A 1 16 ? 62.002 35.366 -31.231 1.00 48.73 ? 76 GLU B O 1 ATOM 116 C CB . GLU A 1 16 ? 58.889 35.711 -31.514 1.00 40.11 ? 76 GLU B CB 1 ATOM 117 C CG . GLU A 1 16 ? 57.561 36.419 -31.738 1.00 40.52 ? 76 GLU B CG 1 ATOM 118 C CD . GLU A 1 16 ? 56.537 35.510 -32.414 1.00 42.46 ? 76 GLU B CD 1 ATOM 119 O OE1 . GLU A 1 16 ? 55.585 36.027 -33.051 1.00 35.73 ? 76 GLU B OE1 1 ATOM 120 O OE2 . GLU A 1 16 ? 56.691 34.270 -32.303 1.00 45.74 ? 76 GLU B OE2 1 ATOM 121 N N . ILE A 1 17 ? 61.104 35.052 -29.184 1.00 46.34 ? 77 ILE B N 1 ATOM 122 C CA . ILE A 1 17 ? 62.033 33.990 -28.791 1.00 49.64 ? 77 ILE B CA 1 ATOM 123 C C . ILE A 1 17 ? 61.289 32.690 -28.484 1.00 50.68 ? 77 ILE B C 1 ATOM 124 O O . ILE A 1 17 ? 60.293 32.699 -27.768 1.00 54.03 ? 77 ILE B O 1 ATOM 125 C CB . ILE A 1 17 ? 62.903 34.399 -27.584 1.00 53.07 ? 77 ILE B CB 1 ATOM 126 C CG1 . ILE A 1 17 ? 63.981 35.390 -28.020 1.00 51.61 ? 77 ILE B CG1 1 ATOM 127 C CG2 . ILE A 1 17 ? 63.564 33.184 -26.952 1.00 54.25 ? 77 ILE B CG2 1 ATOM 128 C CD1 . ILE A 1 17 ? 64.964 35.717 -26.936 1.00 41.37 ? 77 ILE B CD1 1 ATOM 129 N N . GLN A 1 18 ? 61.769 31.581 -29.046 1.00 52.67 ? 78 GLN B N 1 ATOM 130 C CA . GLN A 1 18 ? 61.110 30.282 -28.896 1.00 51.79 ? 78 GLN B CA 1 ATOM 131 C C . GLN A 1 18 ? 62.076 29.125 -28.627 1.00 57.30 ? 78 GLN B C 1 ATOM 132 O O . GLN A 1 18 ? 62.949 28.834 -29.446 1.00 57.34 ? 78 GLN B O 1 ATOM 133 C CB . GLN A 1 18 ? 60.297 29.968 -30.148 1.00 45.63 ? 78 GLN B CB 1 ATOM 134 C CG . GLN A 1 18 ? 59.938 28.503 -30.294 1.00 42.33 ? 78 GLN B CG 1 ATOM 135 C CD . GLN A 1 18 ? 58.486 28.237 -29.996 1.00 44.21 ? 78 GLN B CD 1 ATOM 136 O OE1 . GLN A 1 18 ? 57.752 29.133 -29.575 1.00 47.53 ? 78 GLN B OE1 1 ATOM 137 N NE2 . GLN A 1 18 ? 58.056 27.000 -30.219 1.00 43.59 ? 78 GLN B NE2 1 ATOM 138 N N . LEU A 1 19 ? 61.905 28.453 -27.491 1.00 62.69 ? 79 LEU B N 1 ATOM 139 C CA . LEU A 1 19 ? 62.718 27.281 -27.160 1.00 62.68 ? 79 LEU B CA 1 ATOM 140 C C . LEU A 1 19 ? 61.888 26.187 -26.474 1.00 63.27 ? 79 LEU B C 1 ATOM 141 O O . LEU A 1 19 ? 61.159 26.465 -25.527 1.00 60.86 ? 79 LEU B O 1 ATOM 142 C CB . LEU A 1 19 ? 63.920 27.692 -26.296 1.00 59.90 ? 79 LEU B CB 1 ATOM 143 C CG . LEU A 1 19 ? 65.050 28.415 -27.050 1.00 56.58 ? 79 LEU B CG 1 ATOM 144 C CD1 . LEU A 1 19 ? 65.488 29.694 -26.350 1.00 57.92 ? 79 LEU B CD1 1 ATOM 145 C CD2 . LEU A 1 19 ? 66.242 27.497 -27.264 1.00 51.90 ? 79 LEU B CD2 1 ATOM 146 N N . LYS A 1 20 ? 61.989 24.952 -26.967 1.00 68.76 ? 80 LYS B N 1 ATOM 147 C CA . LYS A 1 20 ? 61.248 23.824 -26.388 1.00 72.77 ? 80 LYS B CA 1 ATOM 148 C C . LYS A 1 20 ? 62.002 22.485 -26.404 1.00 80.69 ? 80 LYS B C 1 ATOM 149 O O . LYS A 1 20 ? 62.570 22.093 -27.426 1.00 78.20 ? 80 LYS B O 1 ATOM 150 C CB . LYS A 1 20 ? 59.891 23.663 -27.077 1.00 68.91 ? 80 LYS B CB 1 ATOM 151 C CG . LYS A 1 20 ? 58.770 24.482 -26.454 1.00 68.25 ? 80 LYS B CG 1 ATOM 152 C CD . LYS A 1 20 ? 57.510 24.397 -27.297 1.00 69.48 ? 80 LYS B CD 1 ATOM 153 C CE . LYS A 1 20 ? 57.118 22.952 -27.556 1.00 68.87 ? 80 LYS B CE 1 ATOM 154 N NZ . LYS A 1 20 ? 56.167 22.829 -28.692 1.00 65.30 ? 80 LYS B NZ 1 ATOM 155 N N . GLU A 1 21 ? 61.971 21.790 -25.264 1.00 89.71 ? 81 GLU B N 1 ATOM 156 C CA . GLU A 1 21 ? 62.602 20.476 -25.082 1.00 94.33 ? 81 GLU B CA 1 ATOM 157 C C . GLU A 1 21 ? 64.116 20.465 -25.306 1.00 98.87 ? 81 GLU B C 1 ATOM 158 O O . GLU A 1 21 ? 64.641 19.569 -25.970 1.00 102.02 ? 81 GLU B O 1 ATOM 159 C CB . GLU A 1 21 ? 61.931 19.417 -25.967 1.00 92.77 ? 81 GLU B CB 1 ATOM 160 N N . LYS A 1 22 ? 64.809 21.464 -24.766 1.00 98.19 ? 82 LYS B N 1 ATOM 161 C CA . LYS A 1 22 ? 66.264 21.551 -24.909 1.00 97.00 ? 82 LYS B CA 1 ATOM 162 C C . LYS A 1 22 ? 67.066 21.048 -23.700 1.00 91.97 ? 82 LYS B C 1 ATOM 163 O O . LYS A 1 22 ? 68.297 21.108 -23.707 1.00 94.57 ? 82 LYS B O 1 ATOM 164 C CB . LYS A 1 22 ? 66.690 22.971 -25.297 1.00 98.01 ? 82 LYS B CB 1 ATOM 165 N N . GLN A 1 23 ? 66.367 20.574 -22.669 1.00 82.98 ? 83 GLN B N 1 ATOM 166 C CA . GLN A 1 23 ? 66.998 19.958 -21.491 1.00 76.30 ? 83 GLN B CA 1 ATOM 167 C C . GLN A 1 23 ? 68.048 20.815 -20.761 1.00 78.53 ? 83 GLN B C 1 ATOM 168 O O . GLN A 1 23 ? 69.110 20.319 -20.395 1.00 83.08 ? 83 GLN B O 1 ATOM 169 C CB . GLN A 1 23 ? 67.594 18.591 -21.853 1.00 68.50 ? 83 GLN B CB 1 ATOM 170 N N . LEU A 1 24 ? 67.723 22.085 -20.526 1.00 74.67 ? 84 LEU B N 1 ATOM 171 C CA . LEU A 1 24 ? 68.591 23.039 -19.822 1.00 67.87 ? 84 LEU B CA 1 ATOM 172 C C . LEU A 1 24 ? 68.486 22.833 -18.313 1.00 75.11 ? 84 LEU B C 1 ATOM 173 O O . LEU A 1 24 ? 68.031 21.780 -17.862 1.00 75.35 ? 84 LEU B O 1 ATOM 174 C CB . LEU A 1 24 ? 68.218 24.483 -20.167 1.00 59.75 ? 84 LEU B CB 1 ATOM 175 C CG . LEU A 1 24 ? 68.802 25.144 -21.419 1.00 62.70 ? 84 LEU B CG 1 ATOM 176 C CD1 . LEU A 1 24 ? 68.455 24.386 -22.686 1.00 61.32 ? 84 LEU B CD1 1 ATOM 177 C CD2 . LEU A 1 24 ? 68.319 26.584 -21.524 1.00 63.86 ? 84 LEU B CD2 1 ATOM 178 N N . GLN A 1 25 ? 68.933 23.828 -17.543 1.00 79.57 ? 85 GLN B N 1 ATOM 179 C CA . GLN A 1 25 ? 68.808 23.799 -16.083 1.00 78.61 ? 85 GLN B CA 1 ATOM 180 C C . GLN A 1 25 ? 69.225 25.118 -15.432 1.00 81.41 ? 85 GLN B C 1 ATOM 181 O O . GLN A 1 25 ? 69.865 25.963 -16.062 1.00 81.11 ? 85 GLN B O 1 ATOM 182 C CB . GLN A 1 25 ? 69.658 22.667 -15.500 1.00 79.32 ? 85 GLN B CB 1 ATOM 183 C CG . GLN A 1 25 ? 69.131 22.097 -14.203 1.00 81.59 ? 85 GLN B CG 1 ATOM 184 C CD . GLN A 1 25 ? 69.267 20.592 -14.148 1.00 85.29 ? 85 GLN B CD 1 ATOM 185 O OE1 . GLN A 1 25 ? 69.941 20.052 -13.272 1.00 88.79 ? 85 GLN B OE1 1 ATOM 186 N NE2 . GLN A 1 25 ? 68.624 19.902 -15.088 1.00 83.52 ? 85 GLN B NE2 1 ATOM 187 N N . GLY A 1 26 ? 68.838 25.288 -14.168 1.00 82.51 ? 86 GLY B N 1 ATOM 188 C CA . GLY A 1 26 ? 69.202 26.461 -13.391 1.00 81.65 ? 86 GLY B CA 1 ATOM 189 C C . GLY A 1 26 ? 68.185 27.587 -13.441 1.00 76.47 ? 86 GLY B C 1 ATOM 190 O O . GLY A 1 26 ? 67.003 27.368 -13.688 1.00 76.00 ? 86 GLY B O 1 ATOM 191 N N . SER A 1 27 ? 68.658 28.805 -13.202 1.00 73.20 ? 87 SER B N 1 ATOM 192 C CA . SER A 1 27 ? 67.827 29.994 -13.320 1.00 68.29 ? 87 SER B CA 1 ATOM 193 C C . SER A 1 27 ? 67.741 30.361 -14.795 1.00 72.85 ? 87 SER B C 1 ATOM 194 O O . SER A 1 27 ? 68.064 29.544 -15.657 1.00 72.56 ? 87 SER B O 1 ATOM 195 C CB . SER A 1 27 ? 68.389 31.148 -12.487 1.00 61.95 ? 87 SER B CB 1 ATOM 196 O OG . SER A 1 27 ? 68.324 30.858 -11.095 1.00 53.37 ? 87 SER B OG 1 ATOM 197 N N . LEU A 1 28 ? 67.268 31.561 -15.103 1.00 77.38 ? 88 LEU B N 1 ATOM 198 C CA . LEU A 1 28 ? 67.015 31.891 -16.500 1.00 79.77 ? 88 LEU B CA 1 ATOM 199 C C . LEU A 1 28 ? 67.423 33.312 -16.879 1.00 81.60 ? 88 LEU B C 1 ATOM 200 O O . LEU A 1 28 ? 67.711 34.140 -16.018 1.00 81.35 ? 88 LEU B O 1 ATOM 201 C CB . LEU A 1 28 ? 65.538 31.669 -16.814 1.00 79.94 ? 88 LEU B CB 1 ATOM 202 C CG . LEU A 1 28 ? 64.592 32.568 -16.018 1.00 80.49 ? 88 LEU B CG 1 ATOM 203 C CD1 . LEU A 1 28 ? 63.928 33.633 -16.911 1.00 83.72 ? 88 LEU B CD1 1 ATOM 204 C CD2 . LEU A 1 28 ? 63.554 31.743 -15.249 1.00 77.36 ? 88 LEU B CD2 1 ATOM 205 N N . LEU A 1 36 ? 67.229 44.594 -26.612 1.00 64.36 ? 92 LEU B N 1 ATOM 206 C CA . LEU A 1 36 ? 66.019 44.099 -27.269 1.00 62.59 ? 92 LEU B CA 1 ATOM 207 C C . LEU A 1 36 ? 64.767 44.334 -26.423 1.00 66.38 ? 92 LEU B C 1 ATOM 208 O O . LEU A 1 36 ? 64.154 43.405 -25.896 1.00 65.37 ? 92 LEU B O 1 ATOM 209 C CB . LEU A 1 36 ? 66.165 42.625 -27.694 1.00 55.54 ? 92 LEU B CB 1 ATOM 210 C CG . LEU A 1 36 ? 66.223 41.418 -26.741 1.00 53.01 ? 92 LEU B CG 1 ATOM 211 C CD1 . LEU A 1 36 ? 66.670 40.187 -27.522 1.00 49.66 ? 92 LEU B CD1 1 ATOM 212 C CD2 . LEU A 1 36 ? 67.093 41.625 -25.485 1.00 51.36 ? 92 LEU B CD2 1 ATOM 213 N N . LYS A 1 37 ? 64.387 45.600 -26.310 1.00 71.03 ? 93 LYS B N 1 ATOM 214 C CA . LYS A 1 37 ? 63.235 45.987 -25.509 1.00 71.97 ? 93 LYS B CA 1 ATOM 215 C C . LYS A 1 37 ? 61.978 45.950 -26.373 1.00 65.56 ? 93 LYS B C 1 ATOM 216 O O . LYS A 1 37 ? 60.904 46.376 -25.949 1.00 62.79 ? 93 LYS B O 1 ATOM 217 C CB . LYS A 1 37 ? 63.464 47.364 -24.879 1.00 76.67 ? 93 LYS B CB 1 ATOM 218 C CG . LYS A 1 37 ? 64.786 47.444 -24.115 1.00 81.29 ? 93 LYS B CG 1 ATOM 219 C CD . LYS A 1 37 ? 65.043 48.816 -23.504 1.00 84.94 ? 93 LYS B CD 1 ATOM 220 C CE . LYS A 1 37 ? 64.344 48.989 -22.161 1.00 81.74 ? 93 LYS B CE 1 ATOM 221 N NZ . LYS A 1 37 ? 64.713 50.289 -21.528 1.00 80.10 ? 93 LYS B NZ 1 ATOM 222 N N . SER A 1 38 ? 62.146 45.464 -27.603 1.00 62.67 ? 94 SER B N 1 ATOM 223 C CA . SER A 1 38 ? 61.046 45.274 -28.551 1.00 61.97 ? 94 SER B CA 1 ATOM 224 C C . SER A 1 38 ? 60.481 43.842 -28.657 1.00 63.06 ? 94 SER B C 1 ATOM 225 O O . SER A 1 38 ? 59.594 43.594 -29.481 1.00 64.26 ? 94 SER B O 1 ATOM 226 C CB . SER A 1 38 ? 61.454 45.779 -29.940 1.00 65.15 ? 94 SER B CB 1 ATOM 227 O OG . SER A 1 38 ? 62.848 46.031 -29.998 1.00 70.50 ? 94 SER B OG 1 ATOM 228 N N . LEU A 1 39 ? 60.982 42.907 -27.848 1.00 62.10 ? 95 LEU B N 1 ATOM 229 C CA . LEU A 1 39 ? 60.592 41.499 -27.991 1.00 55.00 ? 95 LEU B CA 1 ATOM 230 C C . LEU A 1 39 ? 59.130 41.337 -27.601 1.00 53.12 ? 95 LEU B C 1 ATOM 231 O O . LEU A 1 39 ? 58.741 41.652 -26.472 1.00 50.32 ? 95 LEU B O 1 ATOM 232 C CB . LEU A 1 39 ? 61.468 40.606 -27.103 1.00 57.09 ? 95 LEU B CB 1 ATOM 233 C CG . LEU A 1 39 ? 61.224 39.091 -27.082 1.00 57.90 ? 95 LEU B CG 1 ATOM 234 C CD1 . LEU A 1 39 ? 61.877 38.390 -28.263 1.00 58.21 ? 95 LEU B CD1 1 ATOM 235 C CD2 . LEU A 1 39 ? 61.711 38.480 -25.773 1.00 56.22 ? 95 LEU B CD2 1 ATOM 236 N N . THR A 1 40 ? 58.323 40.867 -28.552 1.00 50.20 ? 96 THR B N 1 ATOM 237 C CA . THR A 1 40 ? 56.875 40.796 -28.364 1.00 42.51 ? 96 THR B CA 1 ATOM 238 C C . THR A 1 40 ? 56.305 39.458 -27.828 1.00 40.36 ? 96 THR B C 1 ATOM 239 O O . THR A 1 40 ? 55.197 39.414 -27.289 1.00 31.82 ? 96 THR B O 1 ATOM 240 C CB . THR A 1 40 ? 56.155 41.276 -29.660 1.00 39.64 ? 96 THR B CB 1 ATOM 241 O OG1 . THR A 1 40 ? 55.289 42.377 -29.345 1.00 33.64 ? 96 THR B OG1 1 ATOM 242 C CG2 . THR A 1 40 ? 55.379 40.137 -30.358 1.00 32.25 ? 96 THR B CG2 1 ATOM 243 N N . SER A 1 41 ? 57.081 38.387 -27.938 1.00 33.30 ? 97 SER B N 1 ATOM 244 C CA . SER A 1 41 ? 56.665 37.088 -27.428 1.00 32.07 ? 97 SER B CA 1 ATOM 245 C C . SER A 1 41 ? 57.841 36.289 -26.898 1.00 42.26 ? 97 SER B C 1 ATOM 246 O O . SER A 1 41 ? 58.878 36.183 -27.548 1.00 34.12 ? 97 SER B O 1 ATOM 247 C CB . SER A 1 41 ? 55.944 36.282 -28.493 1.00 30.71 ? 97 SER B CB 1 ATOM 248 O OG . SER A 1 41 ? 56.307 34.917 -28.408 1.00 51.70 ? 97 SER B OG 1 ATOM 249 N N . LEU A 1 42 ? 57.660 35.704 -25.720 1.00 43.38 ? 98 LEU B N 1 ATOM 250 C CA . LEU A 1 42 ? 58.736 34.973 -25.076 1.00 43.85 ? 98 LEU B CA 1 ATOM 251 C C . LEU A 1 42 ? 58.286 33.586 -24.678 1.00 43.14 ? 98 LEU B C 1 ATOM 252 O O . LEU A 1 42 ? 57.359 33.431 -23.890 1.00 45.22 ? 98 LEU B O 1 ATOM 253 C CB . LEU A 1 42 ? 59.229 35.730 -23.850 1.00 40.64 ? 98 LEU B CB 1 ATOM 254 C CG . LEU A 1 42 ? 60.459 35.083 -23.229 1.00 42.50 ? 98 LEU B CG 1 ATOM 255 C CD1 . LEU A 1 42 ? 61.558 34.956 -24.283 1.00 40.76 ? 98 LEU B CD1 1 ATOM 256 C CD2 . LEU A 1 42 ? 60.927 35.878 -22.012 1.00 36.74 ? 98 LEU B CD2 1 ATOM 257 N N . THR A 1 43 ? 58.935 32.575 -25.238 1.00 40.94 ? 99 THR B N 1 ATOM 258 C CA . THR A 1 43 ? 58.604 31.213 -24.883 1.00 36.71 ? 99 THR B CA 1 ATOM 259 C C . THR A 1 43 ? 59.843 30.463 -24.476 1.00 42.96 ? 99 THR B C 1 ATOM 260 O O . THR A 1 43 ? 60.686 30.127 -25.307 1.00 47.17 ? 99 THR B O 1 ATOM 261 C CB . THR A 1 43 ? 57.991 30.476 -26.066 1.00 35.95 ? 99 THR B CB 1 ATOM 262 O OG1 . THR A 1 43 ? 56.747 31.092 -26.410 1.00 43.77 ? 99 THR B OG1 1 ATOM 263 C CG2 . THR A 1 43 ? 57.753 29.021 -25.718 1.00 30.36 ? 99 THR B CG2 1 ATOM 264 N N . LEU A 1 44 ? 59.939 30.186 -23.184 1.00 47.31 ? 100 LEU B N 1 ATOM 265 C CA . LEU A 1 44 ? 60.936 29.270 -22.677 1.00 49.65 ? 100 LEU B CA 1 ATOM 266 C C . LEU A 1 44 ? 60.161 28.191 -21.945 1.00 51.83 ? 100 LEU B C 1 ATOM 267 O O . LEU A 1 44 ? 59.657 28.417 -20.847 1.00 50.01 ? 100 LEU B O 1 ATOM 268 C CB . LEU A 1 44 ? 61.892 30.015 -21.749 1.00 48.36 ? 100 LEU B CB 1 ATOM 269 C CG . LEU A 1 44 ? 62.574 31.189 -22.468 1.00 44.97 ? 100 LEU B CG 1 ATOM 270 C CD1 . LEU A 1 44 ? 63.424 32.029 -21.533 1.00 43.90 ? 100 LEU B CD1 1 ATOM 271 C CD2 . LEU A 1 44 ? 63.404 30.689 -23.648 1.00 39.62 ? 100 LEU B CD2 1 ATOM 272 N N . SER A 1 45 ? 60.101 27.009 -22.549 1.00 53.29 ? 101 SER B N 1 ATOM 273 C CA . SER A 1 45 ? 59.177 25.964 -22.129 1.00 50.22 ? 101 SER B CA 1 ATOM 274 C C . SER A 1 45 ? 59.812 24.592 -22.326 1.00 50.12 ? 101 SER B C 1 ATOM 275 O O . SER A 1 45 ? 60.480 24.360 -23.331 1.00 49.77 ? 101 SER B O 1 ATOM 276 C CB . SER A 1 45 ? 57.884 26.076 -22.937 1.00 51.81 ? 101 SER B CB 1 ATOM 277 O OG . SER A 1 45 ? 56.985 25.032 -22.619 1.00 61.51 ? 101 SER B OG 1 ATOM 278 N N . SER A 1 46 ? 59.598 23.693 -21.366 1.00 51.59 ? 102 SER B N 1 ATOM 279 C CA . SER A 1 46 ? 60.262 22.381 -21.339 1.00 54.38 ? 102 SER B CA 1 ATOM 280 C C . SER A 1 46 ? 61.787 22.492 -21.219 1.00 59.34 ? 102 SER B C 1 ATOM 281 O O . SER A 1 46 ? 62.529 21.702 -21.810 1.00 61.49 ? 102 SER B O 1 ATOM 282 C CB . SER A 1 46 ? 59.883 21.539 -22.562 1.00 49.13 ? 102 SER B CB 1 ATOM 283 O OG . SER A 1 46 ? 58.478 21.372 -22.644 1.00 46.87 ? 102 SER B OG 1 ATOM 284 N N . LEU A 1 47 ? 62.246 23.507 -20.490 1.00 56.09 ? 103 LEU B N 1 ATOM 285 C CA . LEU A 1 47 ? 63.678 23.753 -20.327 1.00 53.90 ? 103 LEU B CA 1 ATOM 286 C C . LEU A 1 47 ? 64.330 23.316 -19.002 1.00 52.27 ? 103 LEU B C 1 ATOM 287 O O . LEU A 1 47 ? 65.513 23.554 -18.788 1.00 53.65 ? 103 LEU B O 1 ATOM 288 C CB . LEU A 1 47 ? 64.001 25.208 -20.670 1.00 51.56 ? 103 LEU B CB 1 ATOM 289 C CG . LEU A 1 47 ? 63.580 25.523 -22.108 1.00 41.60 ? 103 LEU B CG 1 ATOM 290 C CD1 . LEU A 1 47 ? 63.741 26.995 -22.411 1.00 41.09 ? 103 LEU B CD1 1 ATOM 291 C CD2 . LEU A 1 47 ? 64.374 24.671 -23.087 1.00 39.51 ? 103 LEU B CD2 1 ATOM 292 N N . GLN A 1 48 ? 63.554 22.710 -18.111 1.00 50.83 ? 104 GLN B N 1 ATOM 293 C CA . GLN A 1 48 ? 64.071 22.211 -16.831 1.00 45.24 ? 104 GLN B CA 1 ATOM 294 C C . GLN A 1 48 ? 64.715 23.302 -15.968 1.00 43.25 ? 104 GLN B C 1 ATOM 295 O O . GLN A 1 48 ? 65.550 23.015 -15.115 1.00 48.46 ? 104 GLN B O 1 ATOM 296 C CB . GLN A 1 48 ? 65.038 21.039 -17.047 1.00 37.98 ? 104 GLN B CB 1 ATOM 297 N N . LEU A 1 49 ? 64.308 24.548 -16.186 1.00 39.17 ? 105 LEU B N 1 ATOM 298 C CA . LEU A 1 49 ? 64.826 25.680 -15.424 1.00 38.88 ? 105 LEU B CA 1 ATOM 299 C C . LEU A 1 49 ? 64.364 25.629 -13.972 1.00 42.31 ? 105 LEU B C 1 ATOM 300 O O . LEU A 1 49 ? 63.313 25.068 -13.668 1.00 44.69 ? 105 LEU B O 1 ATOM 301 C CB . LEU A 1 49 ? 64.355 26.998 -16.040 1.00 42.75 ? 105 LEU B CB 1 ATOM 302 C CG . LEU A 1 49 ? 64.970 27.529 -17.339 1.00 53.02 ? 105 LEU B CG 1 ATOM 303 C CD1 . LEU A 1 49 ? 65.956 26.556 -17.965 1.00 59.68 ? 105 LEU B CD1 1 ATOM 304 C CD2 . LEU A 1 49 ? 63.878 27.907 -18.338 1.00 50.73 ? 105 LEU B CD2 1 ATOM 305 N N . THR A 1 50 ? 65.141 26.235 -13.078 1.00 45.23 ? 106 THR B N 1 ATOM 306 C CA . THR A 1 50 ? 64.763 26.321 -11.671 1.00 36.67 ? 106 THR B CA 1 ATOM 307 C C . THR A 1 50 ? 64.792 27.743 -11.126 1.00 37.54 ? 106 THR B C 1 ATOM 308 O O . THR A 1 50 ? 65.050 28.713 -11.846 1.00 41.74 ? 106 THR B O 1 ATOM 309 C CB . THR A 1 50 ? 65.682 25.471 -10.797 1.00 37.39 ? 106 THR B CB 1 ATOM 310 O OG1 . THR A 1 50 ? 67.040 25.678 -11.203 1.00 41.73 ? 106 THR B OG1 1 ATOM 311 C CG2 . THR A 1 50 ? 65.331 23.997 -10.929 1.00 36.18 ? 106 THR B CG2 1 ATOM 312 N N . GLY A 1 51 ? 64.518 27.855 -9.835 1.00 37.41 ? 107 GLY B N 1 ATOM 313 C CA . GLY A 1 51 ? 64.606 29.129 -9.155 1.00 54.72 ? 107 GLY B CA 1 ATOM 314 C C . GLY A 1 51 ? 63.432 30.036 -9.425 1.00 49.62 ? 107 GLY B C 1 ATOM 315 O O . GLY A 1 51 ? 62.403 29.609 -9.939 1.00 47.17 ? 107 GLY B O 1 ATOM 316 N N . VAL A 1 52 ? 63.596 31.300 -9.064 1.00 51.00 ? 108 VAL B N 1 ATOM 317 C CA . VAL A 1 52 ? 62.540 32.287 -9.210 1.00 57.60 ? 108 VAL B CA 1 ATOM 318 C C . VAL A 1 52 ? 62.438 32.790 -10.655 1.00 59.21 ? 108 VAL B C 1 ATOM 319 O O . VAL A 1 52 ? 63.391 32.692 -11.436 1.00 53.45 ? 108 VAL B O 1 ATOM 320 C CB . VAL A 1 52 ? 62.767 33.468 -8.232 1.00 48.11 ? 108 VAL B CB 1 ATOM 321 C CG1 . VAL A 1 52 ? 61.491 34.272 -8.028 1.00 49.76 ? 108 VAL B CG1 1 ATOM 322 C CG2 . VAL A 1 52 ? 63.261 32.945 -6.892 1.00 46.96 ? 108 VAL B CG2 1 ATOM 323 N N . ILE A 1 53 ? 61.252 33.278 -11.010 1.00 61.90 ? 109 ILE B N 1 ATOM 324 C CA . ILE A 1 53 ? 61.070 34.089 -12.208 1.00 64.15 ? 109 ILE B CA 1 ATOM 325 C C . ILE A 1 53 ? 61.730 35.433 -11.931 1.00 63.27 ? 109 ILE B C 1 ATOM 326 O O . ILE A 1 53 ? 61.313 36.145 -11.015 1.00 58.25 ? 109 ILE B O 1 ATOM 327 C CB . ILE A 1 53 ? 59.582 34.358 -12.472 1.00 63.71 ? 109 ILE B CB 1 ATOM 328 C CG1 . ILE A 1 53 ? 58.813 33.055 -12.663 1.00 60.30 ? 109 ILE B CG1 1 ATOM 329 C CG2 . ILE A 1 53 ? 59.417 35.272 -13.667 1.00 64.61 ? 109 ILE B CG2 1 ATOM 330 C CD1 . ILE A 1 53 ? 57.316 33.233 -12.721 1.00 56.37 ? 109 ILE B CD1 1 ATOM 331 N N . PRO A 1 54 ? 62.773 35.778 -12.698 1.00 67.56 ? 110 PRO B N 1 ATOM 332 C CA . PRO A 1 54 ? 63.471 37.042 -12.462 1.00 70.66 ? 110 PRO B CA 1 ATOM 333 C C . PRO A 1 54 ? 62.506 38.208 -12.543 1.00 78.21 ? 110 PRO B C 1 ATOM 334 O O . PRO A 1 54 ? 61.754 38.298 -13.512 1.00 79.79 ? 110 PRO B O 1 ATOM 335 C CB . PRO A 1 54 ? 64.479 37.130 -13.602 1.00 63.62 ? 110 PRO B CB 1 ATOM 336 C CG . PRO A 1 54 ? 64.536 35.805 -14.222 1.00 60.90 ? 110 PRO B CG 1 ATOM 337 C CD . PRO A 1 54 ? 63.461 34.930 -13.675 1.00 65.12 ? 110 PRO B CD 1 ATOM 338 N N . LYS A 1 55 ? 62.559 39.089 -11.547 1.00 79.99 ? 111 LYS B N 1 ATOM 339 C CA . LYS A 1 55 ? 61.695 40.261 -11.458 1.00 81.94 ? 111 LYS B CA 1 ATOM 340 C C . LYS A 1 55 ? 61.938 41.231 -12.625 1.00 85.02 ? 111 LYS B C 1 ATOM 341 O O . LYS A 1 55 ? 61.198 42.198 -12.819 1.00 85.56 ? 111 LYS B O 1 ATOM 342 C CB . LYS A 1 55 ? 61.906 40.949 -10.102 1.00 84.04 ? 111 LYS B CB 1 ATOM 343 C CG . LYS A 1 55 ? 61.665 40.006 -8.910 1.00 80.31 ? 111 LYS B CG 1 ATOM 344 C CD . LYS A 1 55 ? 62.083 40.589 -7.563 1.00 74.77 ? 111 LYS B CD 1 ATOM 345 C CE . LYS A 1 55 ? 63.584 40.486 -7.348 1.00 74.76 ? 111 LYS B CE 1 ATOM 346 N NZ . LYS A 1 55 ? 64.077 39.086 -7.466 1.00 73.41 ? 111 LYS B NZ 1 ATOM 347 N N . GLU A 1 56 ? 62.976 40.952 -13.408 1.00 87.43 ? 112 GLU B N 1 ATOM 348 C CA . GLU A 1 56 ? 63.333 41.765 -14.564 1.00 88.93 ? 112 GLU B CA 1 ATOM 349 C C . GLU A 1 56 ? 62.507 41.371 -15.776 1.00 90.56 ? 112 GLU B C 1 ATOM 350 O O . GLU A 1 56 ? 62.719 41.888 -16.870 1.00 92.76 ? 112 GLU B O 1 ATOM 351 C CB . GLU A 1 56 ? 64.816 41.604 -14.905 1.00 90.34 ? 112 GLU B CB 1 ATOM 352 C CG . GLU A 1 56 ? 65.766 42.015 -13.801 1.00 93.13 ? 112 GLU B CG 1 ATOM 353 C CD . GLU A 1 56 ? 66.778 40.934 -13.488 1.00 95.27 ? 112 GLU B CD 1 ATOM 354 O OE1 . GLU A 1 56 ? 66.841 39.941 -14.246 1.00 94.05 ? 112 GLU B OE1 1 ATOM 355 O OE2 . GLU A 1 56 ? 67.505 41.074 -12.481 1.00 97.76 ? 112 GLU B OE2 1 ATOM 356 N N . ILE A 1 57 ? 61.587 40.432 -15.591 1.00 89.06 ? 113 ILE B N 1 ATOM 357 C CA . ILE A 1 57 ? 60.719 40.011 -16.686 1.00 85.79 ? 113 ILE B CA 1 ATOM 358 C C . ILE A 1 57 ? 59.870 41.186 -17.175 1.00 80.96 ? 113 ILE B C 1 ATOM 359 O O . ILE A 1 57 ? 59.473 41.231 -18.340 1.00 80.21 ? 113 ILE B O 1 ATOM 360 C CB . ILE A 1 57 ? 59.835 38.797 -16.295 1.00 59.10 ? 113 ILE B CB 1 ATOM 361 C CG1 . ILE A 1 57 ? 60.039 37.637 -17.284 1.00 52.56 ? 113 ILE B CG1 1 ATOM 362 C CG2 . ILE A 1 57 ? 58.370 39.198 -16.158 1.00 53.07 ? 113 ILE B CG2 1 ATOM 363 C CD1 . ILE A 1 57 ? 60.061 38.051 -18.732 1.00 48.67 ? 113 ILE B CD1 1 ATOM 364 N N . GLY A 1 58 ? 59.617 42.148 -16.291 1.00 78.57 ? 114 GLY B N 1 ATOM 365 C CA . GLY A 1 58 ? 58.919 43.362 -16.671 1.00 79.13 ? 114 GLY B CA 1 ATOM 366 C C . GLY A 1 58 ? 59.709 44.231 -17.642 1.00 81.04 ? 114 GLY B C 1 ATOM 367 O O . GLY A 1 58 ? 59.134 45.108 -18.292 1.00 78.64 ? 114 GLY B O 1 ATOM 368 N N . ASP A 1 59 ? 61.018 43.982 -17.748 1.00 82.96 ? 115 ASP B N 1 ATOM 369 C CA . ASP A 1 59 ? 61.913 44.777 -18.604 1.00 81.62 ? 115 ASP B CA 1 ATOM 370 C C . ASP A 1 59 ? 61.627 44.658 -20.103 1.00 84.20 ? 115 ASP B C 1 ATOM 371 O O . ASP A 1 59 ? 62.157 45.439 -20.898 1.00 91.04 ? 115 ASP B O 1 ATOM 372 C CB . ASP A 1 59 ? 63.390 44.449 -18.349 1.00 78.50 ? 115 ASP B CB 1 ATOM 373 C CG . ASP A 1 59 ? 63.862 44.893 -16.982 1.00 79.98 ? 115 ASP B CG 1 ATOM 374 O OD1 . ASP A 1 59 ? 63.088 45.575 -16.273 1.00 81.51 ? 115 ASP B OD1 1 ATOM 375 O OD2 . ASP A 1 59 ? 65.016 44.568 -16.623 1.00 79.51 ? 115 ASP B OD2 1 ATOM 376 N N . PHE A 1 60 ? 60.812 43.683 -20.497 1.00 76.06 ? 116 PHE B N 1 ATOM 377 C CA . PHE A 1 60 ? 60.331 43.655 -21.870 1.00 66.36 ? 116 PHE B CA 1 ATOM 378 C C . PHE A 1 60 ? 58.901 44.174 -21.843 1.00 61.34 ? 116 PHE B C 1 ATOM 379 O O . PHE A 1 60 ? 57.970 43.437 -21.537 1.00 59.39 ? 116 PHE B O 1 ATOM 380 C CB . PHE A 1 60 ? 60.325 42.226 -22.414 1.00 60.72 ? 116 PHE B CB 1 ATOM 381 C CG . PHE A 1 60 ? 61.529 41.407 -22.024 1.00 63.39 ? 116 PHE B CG 1 ATOM 382 C CD1 . PHE A 1 60 ? 61.548 40.691 -20.832 1.00 64.25 ? 116 PHE B CD1 1 ATOM 383 C CD2 . PHE A 1 60 ? 62.626 41.321 -22.869 1.00 63.67 ? 116 PHE B CD2 1 ATOM 384 C CE1 . PHE A 1 60 ? 62.645 39.925 -20.484 1.00 63.98 ? 116 PHE B CE1 1 ATOM 385 C CE2 . PHE A 1 60 ? 63.726 40.559 -22.528 1.00 60.65 ? 116 PHE B CE2 1 ATOM 386 C CZ . PHE A 1 60 ? 63.736 39.860 -21.337 1.00 63.18 ? 116 PHE B CZ 1 ATOM 387 N N . THR A 1 61 ? 58.710 45.419 -22.250 1.00 62.39 ? 117 THR B N 1 ATOM 388 C CA . THR A 1 61 ? 57.422 46.067 -22.053 1.00 59.08 ? 117 THR B CA 1 ATOM 389 C C . THR A 1 61 ? 56.513 45.793 -23.240 1.00 51.28 ? 117 THR B C 1 ATOM 390 O O . THR A 1 61 ? 55.348 46.197 -23.253 1.00 44.19 ? 117 THR B O 1 ATOM 391 C CB . THR A 1 61 ? 57.585 47.586 -21.803 1.00 61.00 ? 117 THR B CB 1 ATOM 392 O OG1 . THR A 1 61 ? 58.513 48.137 -22.748 1.00 60.37 ? 117 THR B OG1 1 ATOM 393 C CG2 . THR A 1 61 ? 58.109 47.836 -20.389 1.00 59.13 ? 117 THR B CG2 1 ATOM 394 N N . GLU A 1 62 ? 57.070 45.093 -24.228 1.00 51.95 ? 118 GLU B N 1 ATOM 395 C CA . GLU A 1 62 ? 56.390 44.796 -25.486 1.00 49.42 ? 118 GLU B CA 1 ATOM 396 C C . GLU A 1 62 ? 55.733 43.411 -25.602 1.00 45.88 ? 118 GLU B C 1 ATOM 397 O O . GLU A 1 62 ? 55.220 43.052 -26.655 1.00 42.07 ? 118 GLU B O 1 ATOM 398 C CB . GLU A 1 62 ? 57.352 45.033 -26.650 1.00 57.71 ? 118 GLU B CB 1 ATOM 399 C CG . GLU A 1 62 ? 56.830 46.052 -27.655 1.00 59.01 ? 118 GLU B CG 1 ATOM 400 C CD . GLU A 1 62 ? 56.259 47.288 -26.976 1.00 52.40 ? 118 GLU B CD 1 ATOM 401 O OE1 . GLU A 1 62 ? 56.927 47.838 -26.069 1.00 45.26 ? 118 GLU B OE1 1 ATOM 402 O OE2 . GLU A 1 62 ? 55.137 47.702 -27.348 1.00 52.23 ? 118 GLU B OE2 1 ATOM 403 N N . LEU A 1 63 ? 55.757 42.633 -24.529 1.00 54.34 ? 119 LEU B N 1 ATOM 404 C CA . LEU A 1 63 ? 55.333 41.236 -24.591 1.00 49.63 ? 119 LEU B CA 1 ATOM 405 C C . LEU A 1 63 ? 53.816 41.063 -24.647 1.00 46.70 ? 119 LEU B C 1 ATOM 406 O O . LEU A 1 63 ? 53.105 41.535 -23.765 1.00 50.26 ? 119 LEU B O 1 ATOM 407 C CB . LEU A 1 63 ? 55.884 40.494 -23.376 1.00 44.04 ? 119 LEU B CB 1 ATOM 408 C CG . LEU A 1 63 ? 56.545 39.143 -23.628 1.00 48.56 ? 119 LEU B CG 1 ATOM 409 C CD1 . LEU A 1 63 ? 57.557 39.247 -24.742 1.00 46.42 ? 119 LEU B CD1 1 ATOM 410 C CD2 . LEU A 1 63 ? 57.220 38.663 -22.350 1.00 53.44 ? 119 LEU B CD2 1 ATOM 411 N N . GLU A 1 64 ? 53.322 40.416 -25.701 1.00 38.64 ? 120 GLU B N 1 ATOM 412 C CA . GLU A 1 64 ? 51.934 39.965 -25.736 1.00 33.54 ? 120 GLU B CA 1 ATOM 413 C C . GLU A 1 64 ? 51.777 38.528 -25.255 1.00 32.11 ? 120 GLU B C 1 ATOM 414 O O . GLU A 1 64 ? 50.671 38.084 -24.955 1.00 30.92 ? 120 GLU B O 1 ATOM 415 C CB . GLU A 1 64 ? 51.382 40.046 -27.158 1.00 42.26 ? 120 GLU B CB 1 ATOM 416 C CG . GLU A 1 64 ? 51.563 41.378 -27.847 1.00 47.81 ? 120 GLU B CG 1 ATOM 417 C CD . GLU A 1 64 ? 50.788 41.445 -29.137 1.00 55.21 ? 120 GLU B CD 1 ATOM 418 O OE1 . GLU A 1 64 ? 50.155 40.427 -29.508 1.00 54.45 ? 120 GLU B OE1 1 ATOM 419 O OE2 . GLU A 1 64 ? 50.801 42.518 -29.774 1.00 62.45 ? 120 GLU B OE2 1 ATOM 420 N N . LEU A 1 65 ? 52.884 37.796 -25.192 1.00 36.86 ? 121 LEU B N 1 ATOM 421 C CA . LEU A 1 65 ? 52.836 36.388 -24.827 1.00 27.58 ? 121 LEU B CA 1 ATOM 422 C C . LEU A 1 65 ? 54.006 36.008 -23.956 1.00 31.77 ? 121 LEU B C 1 ATOM 423 O O . LEU A 1 65 ? 55.156 36.214 -24.336 1.00 32.40 ? 121 LEU B O 1 ATOM 424 C CB . LEU A 1 65 ? 52.834 35.495 -26.072 1.00 34.94 ? 121 LEU B CB 1 ATOM 425 C CG . LEU A 1 65 ? 53.001 33.991 -25.790 1.00 36.83 ? 121 LEU B CG 1 ATOM 426 C CD1 . LEU A 1 65 ? 51.957 33.138 -26.506 1.00 29.45 ? 121 LEU B CD1 1 ATOM 427 C CD2 . LEU A 1 65 ? 54.402 33.498 -26.127 1.00 36.68 ? 121 LEU B CD2 1 ATOM 428 N N . LEU A 1 66 ? 53.718 35.421 -22.798 1.00 39.60 ? 122 LEU B N 1 ATOM 429 C CA . LEU A 1 66 ? 54.770 34.844 -21.970 1.00 39.41 ? 122 LEU B CA 1 ATOM 430 C C . LEU A 1 66 ? 54.418 33.394 -21.699 1.00 32.92 ? 122 LEU B C 1 ATOM 431 O O . LEU A 1 66 ? 53.428 33.110 -21.037 1.00 37.36 ? 122 LEU B O 1 ATOM 432 C CB . LEU A 1 66 ? 54.923 35.616 -20.658 1.00 36.54 ? 122 LEU B CB 1 ATOM 433 C CG . LEU A 1 66 ? 56.118 35.219 -19.784 1.00 38.32 ? 122 LEU B CG 1 ATOM 434 C CD1 . LEU A 1 66 ? 57.396 35.247 -20.604 1.00 34.46 ? 122 LEU B CD1 1 ATOM 435 C CD2 . LEU A 1 66 ? 56.246 36.116 -18.555 1.00 31.80 ? 122 LEU B CD2 1 ATOM 436 N N . ASP A 1 67 ? 55.206 32.475 -22.243 1.00 29.72 ? 123 ASP B N 1 ATOM 437 C CA . ASP A 1 67 ? 55.005 31.061 -21.963 1.00 34.43 ? 123 ASP B CA 1 ATOM 438 C C . ASP A 1 67 ? 56.212 30.510 -21.223 1.00 40.98 ? 123 ASP B C 1 ATOM 439 O O . ASP A 1 67 ? 57.253 30.246 -21.823 1.00 49.18 ? 123 ASP B O 1 ATOM 440 C CB . ASP A 1 67 ? 54.809 30.303 -23.281 1.00 43.45 ? 123 ASP B CB 1 ATOM 441 C CG . ASP A 1 67 ? 54.738 28.796 -23.095 1.00 47.13 ? 123 ASP B CG 1 ATOM 442 O OD1 . ASP A 1 67 ? 54.318 28.338 -22.011 1.00 45.82 ? 123 ASP B OD1 1 ATOM 443 O OD2 . ASP A 1 67 ? 55.100 28.068 -24.044 1.00 47.43 ? 123 ASP B OD2 1 ATOM 444 N N . LEU A 1 68 ? 56.060 30.324 -19.919 1.00 42.34 ? 124 LEU B N 1 ATOM 445 C CA . LEU A 1 68 ? 57.097 29.709 -19.097 1.00 40.40 ? 124 LEU B CA 1 ATOM 446 C C . LEU A 1 68 ? 56.828 28.244 -18.755 1.00 39.18 ? 124 LEU B C 1 ATOM 447 O O . LEU A 1 68 ? 57.558 27.643 -17.969 1.00 41.29 ? 124 LEU B O 1 ATOM 448 C CB . LEU A 1 68 ? 57.412 30.559 -17.864 1.00 38.61 ? 124 LEU B CB 1 ATOM 449 C CG . LEU A 1 68 ? 58.073 31.881 -18.277 1.00 40.53 ? 124 LEU B CG 1 ATOM 450 C CD1 . LEU A 1 68 ? 58.438 32.744 -17.072 1.00 32.39 ? 124 LEU B CD1 1 ATOM 451 C CD2 . LEU A 1 68 ? 59.290 31.625 -19.168 1.00 32.52 ? 124 LEU B CD2 1 ATOM 452 N N . SER A 1 69 ? 55.769 27.691 -19.340 1.00 40.37 ? 125 SER B N 1 ATOM 453 C CA . SER A 1 69 ? 55.197 26.412 -18.900 1.00 42.12 ? 125 SER B CA 1 ATOM 454 C C . SER A 1 69 ? 56.151 25.213 -18.897 1.00 36.37 ? 125 SER B C 1 ATOM 455 O O . SER A 1 69 ? 57.114 25.167 -19.662 1.00 30.16 ? 125 SER B O 1 ATOM 456 C CB . SER A 1 69 ? 53.937 26.074 -19.714 1.00 37.62 ? 125 SER B CB 1 ATOM 457 O OG . SER A 1 69 ? 54.260 25.575 -21.002 1.00 32.18 ? 125 SER B OG 1 ATOM 458 N N . ASP A 1 70 ? 55.874 24.260 -18.008 1.00 33.84 ? 126 ASP B N 1 ATOM 459 C CA . ASP A 1 70 ? 56.619 23.003 -17.941 1.00 38.69 ? 126 ASP B CA 1 ATOM 460 C C . ASP A 1 70 ? 58.114 23.183 -17.647 1.00 46.21 ? 126 ASP B C 1 ATOM 461 O O . ASP A 1 70 ? 58.969 22.848 -18.468 1.00 52.55 ? 126 ASP B O 1 ATOM 462 C CB . ASP A 1 70 ? 56.436 22.207 -19.239 1.00 37.79 ? 126 ASP B CB 1 ATOM 463 C CG . ASP A 1 70 ? 56.826 20.751 -19.085 1.00 40.98 ? 126 ASP B CG 1 ATOM 464 O OD1 . ASP A 1 70 ? 56.638 20.209 -17.967 1.00 39.30 ? 126 ASP B OD1 1 ATOM 465 O OD2 . ASP A 1 70 ? 57.318 20.156 -20.076 1.00 36.84 ? 126 ASP B OD2 1 ATOM 466 N N . ASN A 1 71 ? 58.410 23.703 -16.461 1.00 45.81 ? 127 ASN B N 1 ATOM 467 C CA . ASN A 1 71 ? 59.774 23.840 -15.965 1.00 49.58 ? 127 ASN B CA 1 ATOM 468 C C . ASN A 1 71 ? 59.711 23.438 -14.508 1.00 56.15 ? 127 ASN B C 1 ATOM 469 O O . ASN A 1 71 ? 58.707 22.890 -14.051 1.00 55.34 ? 127 ASN B O 1 ATOM 470 C CB . ASN A 1 71 ? 60.273 25.289 -16.042 1.00 48.88 ? 127 ASN B CB 1 ATOM 471 C CG . ASN A 1 71 ? 60.468 25.781 -17.466 1.00 56.63 ? 127 ASN B CG 1 ATOM 472 O OD1 . ASN A 1 71 ? 60.985 25.066 -18.330 1.00 58.78 ? 127 ASN B OD1 1 ATOM 473 N ND2 . ASN A 1 71 ? 60.056 27.021 -17.716 1.00 59.59 ? 127 ASN B ND2 1 ATOM 474 N N . SER A 1 72 ? 60.797 23.668 -13.785 1.00 56.87 ? 128 SER B N 1 ATOM 475 C CA . SER A 1 72 ? 60.773 23.536 -12.338 1.00 46.41 ? 128 SER B CA 1 ATOM 476 C C . SER A 1 72 ? 60.634 24.852 -11.584 1.00 31.06 ? 128 SER B C 1 ATOM 477 O O . SER A 1 72 ? 60.670 24.853 -10.365 1.00 47.77 ? 128 SER B O 1 ATOM 478 C CB . SER A 1 72 ? 61.977 22.740 -11.854 1.00 43.08 ? 128 SER B CB 1 ATOM 479 O OG . SER A 1 72 ? 61.842 21.389 -12.249 1.00 43.07 ? 128 SER B OG 1 ATOM 480 N N . LEU A 1 73 ? 60.456 25.957 -12.300 1.00 45.35 ? 129 LEU B N 1 ATOM 481 C CA . LEU A 1 73 ? 60.547 27.300 -11.708 1.00 50.16 ? 129 LEU B CA 1 ATOM 482 C C . LEU A 1 73 ? 59.766 27.497 -10.396 1.00 50.94 ? 129 LEU B C 1 ATOM 483 O O . LEU A 1 73 ? 58.667 26.969 -10.228 1.00 50.24 ? 129 LEU B O 1 ATOM 484 C CB . LEU A 1 73 ? 60.162 28.363 -12.735 1.00 47.87 ? 129 LEU B CB 1 ATOM 485 C CG . LEU A 1 73 ? 61.097 28.340 -13.945 1.00 55.11 ? 129 LEU B CG 1 ATOM 486 C CD1 . LEU A 1 73 ? 60.599 29.221 -15.080 1.00 56.07 ? 129 LEU B CD1 1 ATOM 487 C CD2 . LEU A 1 73 ? 62.481 28.770 -13.524 1.00 59.22 ? 129 LEU B CD2 1 ATOM 488 N N . SER A 1 74 ? 60.370 28.229 -9.458 1.00 51.79 ? 130 SER B N 1 ATOM 489 C CA . SER A 1 74 ? 59.886 28.289 -8.075 1.00 49.24 ? 130 SER B CA 1 ATOM 490 C C . SER A 1 74 ? 59.625 29.711 -7.564 1.00 50.75 ? 130 SER B C 1 ATOM 491 O O . SER A 1 74 ? 59.662 30.681 -8.323 1.00 33.62 ? 130 SER B O 1 ATOM 492 C CB . SER A 1 74 ? 60.877 27.580 -7.138 1.00 42.30 ? 130 SER B CB 1 ATOM 493 O OG . SER A 1 74 ? 61.754 26.717 -7.855 1.00 37.89 ? 130 SER B OG 1 ATOM 494 N N . GLY A 1 75 ? 59.347 29.821 -6.270 1.00 33.05 ? 131 GLY B N 1 ATOM 495 C CA . GLY A 1 75 ? 59.110 31.110 -5.644 1.00 50.92 ? 131 GLY B CA 1 ATOM 496 C C . GLY A 1 75 ? 57.791 31.737 -6.044 1.00 47.10 ? 131 GLY B C 1 ATOM 497 O O . GLY A 1 75 ? 56.982 31.103 -6.715 1.00 51.07 ? 131 GLY B O 1 ATOM 498 N N . ASP A 1 76 ? 57.576 32.986 -5.637 1.00 43.08 ? 132 ASP B N 1 ATOM 499 C CA . ASP A 1 76 ? 56.347 33.699 -5.974 1.00 50.18 ? 132 ASP B CA 1 ATOM 500 C C . ASP A 1 76 ? 56.306 34.132 -7.445 1.00 53.71 ? 132 ASP B C 1 ATOM 501 O O . ASP A 1 76 ? 57.271 33.953 -8.203 1.00 47.70 ? 132 ASP B O 1 ATOM 502 C CB . ASP A 1 76 ? 56.185 34.942 -5.090 1.00 58.55 ? 132 ASP B CB 1 ATOM 503 C CG . ASP A 1 76 ? 55.788 34.610 -3.659 1.00 62.44 ? 132 ASP B CG 1 ATOM 504 O OD1 . ASP A 1 76 ? 56.359 33.669 -3.067 1.00 69.45 ? 132 ASP B OD1 1 ATOM 505 O OD2 . ASP A 1 76 ? 54.904 35.309 -3.118 1.00 58.36 ? 132 ASP B OD2 1 ATOM 506 N N . ILE A 1 77 ? 55.182 34.722 -7.837 1.00 57.44 ? 133 ILE B N 1 ATOM 507 C CA . ILE A 1 77 ? 55.040 35.297 -9.169 1.00 54.54 ? 133 ILE B CA 1 ATOM 508 C C . ILE A 1 77 ? 55.299 36.800 -9.086 1.00 53.03 ? 133 ILE B C 1 ATOM 509 O O . ILE A 1 77 ? 54.475 37.542 -8.548 1.00 32.31 ? 133 ILE B O 1 ATOM 510 C CB . ILE A 1 77 ? 53.632 35.029 -9.752 1.00 46.33 ? 133 ILE B CB 1 ATOM 511 C CG1 . ILE A 1 77 ? 53.450 33.537 -10.031 1.00 41.74 ? 133 ILE B CG1 1 ATOM 512 C CG2 . ILE A 1 77 ? 53.415 35.824 -11.030 1.00 51.12 ? 133 ILE B CG2 1 ATOM 513 C CD1 . ILE A 1 77 ? 52.032 33.151 -10.367 1.00 26.60 ? 133 ILE B CD1 1 ATOM 514 N N . PRO A 1 78 ? 56.444 37.250 -9.630 1.00 47.24 ? 134 PRO B N 1 ATOM 515 C CA . PRO A 1 78 ? 56.867 38.643 -9.465 1.00 43.34 ? 134 PRO B CA 1 ATOM 516 C C . PRO A 1 78 ? 55.751 39.560 -9.897 1.00 46.78 ? 134 PRO B C 1 ATOM 517 O O . PRO A 1 78 ? 55.273 39.412 -11.013 1.00 48.52 ? 134 PRO B O 1 ATOM 518 C CB . PRO A 1 78 ? 58.038 38.762 -10.436 1.00 39.02 ? 134 PRO B CB 1 ATOM 519 C CG . PRO A 1 78 ? 58.572 37.384 -10.538 1.00 41.45 ? 134 PRO B CG 1 ATOM 520 C CD . PRO A 1 78 ? 57.379 36.489 -10.476 1.00 46.46 ? 134 PRO B CD 1 ATOM 521 N N . VAL A 1 79 ? 55.355 40.492 -9.034 1.00 52.72 ? 135 VAL B N 1 ATOM 522 C CA . VAL A 1 79 ? 54.117 41.247 -9.224 1.00 61.03 ? 135 VAL B CA 1 ATOM 523 C C . VAL A 1 79 ? 54.205 42.123 -10.473 1.00 63.36 ? 135 VAL B C 1 ATOM 524 O O . VAL A 1 79 ? 53.194 42.467 -11.097 1.00 61.50 ? 135 VAL B O 1 ATOM 525 C CB . VAL A 1 79 ? 53.788 42.096 -7.971 1.00 63.63 ? 135 VAL B CB 1 ATOM 526 C CG1 . VAL A 1 79 ? 52.446 42.793 -8.119 1.00 60.78 ? 135 VAL B CG1 1 ATOM 527 C CG2 . VAL A 1 79 ? 53.788 41.216 -6.724 1.00 69.70 ? 135 VAL B CG2 1 ATOM 528 N N . GLU A 1 80 ? 55.440 42.436 -10.849 1.00 57.90 ? 136 GLU B N 1 ATOM 529 C CA . GLU A 1 80 ? 55.728 43.293 -11.982 1.00 55.57 ? 136 GLU B CA 1 ATOM 530 C C . GLU A 1 80 ? 55.515 42.566 -13.317 1.00 58.86 ? 136 GLU B C 1 ATOM 531 O O . GLU A 1 80 ? 55.492 43.192 -14.383 1.00 62.18 ? 136 GLU B O 1 ATOM 532 C CB . GLU A 1 80 ? 57.151 43.837 -11.855 1.00 58.45 ? 136 GLU B CB 1 ATOM 533 C CG . GLU A 1 80 ? 57.392 44.670 -10.581 1.00 59.36 ? 136 GLU B CG 1 ATOM 534 C CD . GLU A 1 80 ? 57.640 43.834 -9.321 1.00 54.34 ? 136 GLU B CD 1 ATOM 535 O OE1 . GLU A 1 80 ? 58.810 43.775 -8.881 1.00 51.88 ? 136 GLU B OE1 1 ATOM 536 O OE2 . GLU A 1 80 ? 56.670 43.249 -8.774 1.00 44.77 ? 136 GLU B OE2 1 ATOM 537 N N . ILE A 1 81 ? 55.339 41.245 -13.248 1.00 54.78 ? 137 ILE B N 1 ATOM 538 C CA . ILE A 1 81 ? 54.908 40.455 -14.399 1.00 52.68 ? 137 ILE B CA 1 ATOM 539 C C . ILE A 1 81 ? 53.514 40.929 -14.796 1.00 51.08 ? 137 ILE B C 1 ATOM 540 O O . ILE A 1 81 ? 53.084 40.747 -15.931 1.00 50.19 ? 137 ILE B O 1 ATOM 541 C CB . ILE A 1 81 ? 54.880 38.933 -14.080 1.00 43.22 ? 137 ILE B CB 1 ATOM 542 C CG1 . ILE A 1 81 ? 55.271 38.097 -15.296 1.00 42.17 ? 137 ILE B CG1 1 ATOM 543 C CG2 . ILE A 1 81 ? 53.507 38.487 -13.603 1.00 31.03 ? 137 ILE B CG2 1 ATOM 544 C CD1 . ILE A 1 81 ? 55.358 36.601 -15.009 1.00 36.13 ? 137 ILE B CD1 1 ATOM 545 N N . PHE A 1 82 ? 52.825 41.550 -13.844 1.00 54.80 ? 138 PHE B N 1 ATOM 546 C CA . PHE A 1 82 ? 51.497 42.107 -14.057 1.00 65.86 ? 138 PHE B CA 1 ATOM 547 C C . PHE A 1 82 ? 51.553 43.581 -14.438 1.00 67.82 ? 138 PHE B C 1 ATOM 548 O O . PHE A 1 82 ? 50.528 44.264 -14.454 1.00 66.32 ? 138 PHE B O 1 ATOM 549 C CB . PHE A 1 82 ? 50.619 41.897 -12.826 1.00 75.92 ? 138 PHE B CB 1 ATOM 550 C CG . PHE A 1 82 ? 50.557 40.474 -12.389 1.00 81.92 ? 138 PHE B CG 1 ATOM 551 C CD1 . PHE A 1 82 ? 49.695 39.585 -13.003 1.00 83.32 ? 138 PHE B CD1 1 ATOM 552 C CD2 . PHE A 1 82 ? 51.382 40.015 -11.384 1.00 85.94 ? 138 PHE B CD2 1 ATOM 553 C CE1 . PHE A 1 82 ? 49.651 38.265 -12.610 1.00 83.88 ? 138 PHE B CE1 1 ATOM 554 C CE2 . PHE A 1 82 ? 51.346 38.700 -10.995 1.00 87.93 ? 138 PHE B CE2 1 ATOM 555 C CZ . PHE A 1 82 ? 50.476 37.822 -11.601 1.00 86.05 ? 138 PHE B CZ 1 ATOM 556 N N . ARG A 1 83 ? 52.758 44.083 -14.684 1.00 67.84 ? 139 ARG B N 1 ATOM 557 C CA . ARG A 1 83 ? 52.906 45.431 -15.220 1.00 65.28 ? 139 ARG B CA 1 ATOM 558 C C . ARG A 1 83 ? 52.932 45.448 -16.744 1.00 62.19 ? 139 ARG B C 1 ATOM 559 O O . ARG A 1 83 ? 53.147 46.500 -17.341 1.00 70.51 ? 139 ARG B O 1 ATOM 560 C CB . ARG A 1 83 ? 54.151 46.125 -14.663 1.00 62.25 ? 139 ARG B CB 1 ATOM 561 C CG . ARG A 1 83 ? 54.123 46.299 -13.163 1.00 57.03 ? 139 ARG B CG 1 ATOM 562 C CD . ARG A 1 83 ? 54.293 47.747 -12.741 1.00 57.25 ? 139 ARG B CD 1 ATOM 563 N NE . ARG A 1 83 ? 54.514 47.802 -11.302 1.00 57.33 ? 139 ARG B NE 1 ATOM 564 C CZ . ARG A 1 83 ? 55.712 47.826 -10.723 1.00 54.15 ? 139 ARG B CZ 1 ATOM 565 N NH1 . ARG A 1 83 ? 56.819 47.831 -11.456 1.00 49.83 ? 139 ARG B NH1 1 ATOM 566 N NH2 . ARG A 1 83 ? 55.801 47.849 -9.402 1.00 54.76 ? 139 ARG B NH2 1 ATOM 567 N N . LEU A 1 84 ? 52.723 44.294 -17.374 1.00 53.93 ? 140 LEU B N 1 ATOM 568 C CA . LEU A 1 84 ? 52.735 44.233 -18.834 1.00 52.42 ? 140 LEU B CA 1 ATOM 569 C C . LEU A 1 84 ? 51.318 44.180 -19.383 1.00 61.94 ? 140 LEU B C 1 ATOM 570 O O . LEU A 1 84 ? 50.696 43.118 -19.392 1.00 69.81 ? 140 LEU B O 1 ATOM 571 C CB . LEU A 1 84 ? 53.461 42.970 -19.276 1.00 43.80 ? 140 LEU B CB 1 ATOM 572 C CG . LEU A 1 84 ? 54.639 42.548 -18.410 1.00 39.52 ? 140 LEU B CG 1 ATOM 573 C CD1 . LEU A 1 84 ? 54.872 41.063 -18.534 1.00 38.94 ? 140 LEU B CD1 1 ATOM 574 C CD2 . LEU A 1 84 ? 55.865 43.318 -18.838 1.00 43.51 ? 140 LEU B CD2 1 ATOM 575 N N . LYS A 1 85 ? 50.842 45.301 -19.921 1.00 62.61 ? 141 LYS B N 1 ATOM 576 C CA . LYS A 1 85 ? 49.430 45.433 -20.275 1.00 60.34 ? 141 LYS B CA 1 ATOM 577 C C . LYS A 1 85 ? 49.173 45.094 -21.738 1.00 61.83 ? 141 LYS B C 1 ATOM 578 O O . LYS A 1 85 ? 48.054 45.236 -22.241 1.00 67.13 ? 141 LYS B O 1 ATOM 579 C CB . LYS A 1 85 ? 48.906 46.834 -19.936 1.00 57.59 ? 141 LYS B CB 1 ATOM 580 C CG . LYS A 1 85 ? 47.393 46.908 -19.731 1.00 53.52 ? 141 LYS B CG 1 ATOM 581 C CD . LYS A 1 85 ? 46.900 48.348 -19.788 1.00 56.47 ? 141 LYS B CD 1 ATOM 582 C CE . LYS A 1 85 ? 47.605 49.230 -18.760 1.00 60.79 ? 141 LYS B CE 1 ATOM 583 N NZ . LYS A 1 85 ? 47.195 48.924 -17.349 1.00 64.34 ? 141 LYS B NZ 1 ATOM 584 N N . LYS A 1 86 ? 50.215 44.668 -22.436 1.00 59.28 ? 142 LYS B N 1 ATOM 585 C CA . LYS A 1 86 ? 50.012 44.143 -23.780 1.00 63.32 ? 142 LYS B CA 1 ATOM 586 C C . LYS A 1 86 ? 49.945 42.617 -23.797 1.00 48.05 ? 142 LYS B C 1 ATOM 587 O O . LYS A 1 86 ? 49.792 42.011 -24.857 1.00 43.01 ? 142 LYS B O 1 ATOM 588 C CB . LYS A 1 86 ? 51.067 44.673 -24.759 1.00 76.96 ? 142 LYS B CB 1 ATOM 589 C CG . LYS A 1 86 ? 50.945 46.170 -25.027 1.00 80.77 ? 142 LYS B CG 1 ATOM 590 C CD . LYS A 1 86 ? 51.834 46.634 -26.165 1.00 83.99 ? 142 LYS B CD 1 ATOM 591 C CE . LYS A 1 86 ? 51.617 48.117 -26.433 1.00 89.27 ? 142 LYS B CE 1 ATOM 592 N NZ . LYS A 1 86 ? 52.340 48.577 -27.650 1.00 94.77 ? 142 LYS B NZ 1 ATOM 593 N N . LEU A 1 87 ? 50.031 42.005 -22.616 1.00 35.54 ? 143 LEU B N 1 ATOM 594 C CA . LEU A 1 87 ? 50.106 40.556 -22.522 1.00 29.22 ? 143 LEU B CA 1 ATOM 595 C C . LEU A 1 87 ? 48.717 39.959 -22.758 1.00 30.51 ? 143 LEU B C 1 ATOM 596 O O . LEU A 1 87 ? 47.775 40.259 -22.034 1.00 30.09 ? 143 LEU B O 1 ATOM 597 C CB . LEU A 1 87 ? 50.636 40.165 -21.147 1.00 27.99 ? 143 LEU B CB 1 ATOM 598 C CG . LEU A 1 87 ? 51.228 38.771 -20.962 1.00 50.10 ? 143 LEU B CG 1 ATOM 599 C CD1 . LEU A 1 87 ? 52.484 38.588 -21.787 1.00 50.85 ? 143 LEU B CD1 1 ATOM 600 C CD2 . LEU A 1 87 ? 51.535 38.550 -19.497 1.00 47.58 ? 143 LEU B CD2 1 ATOM 601 N N . LYS A 1 88 ? 48.590 39.168 -23.822 1.00 30.62 ? 144 LYS B N 1 ATOM 602 C CA . LYS A 1 88 ? 47.362 38.449 -24.124 1.00 29.89 ? 144 LYS B CA 1 ATOM 603 C C . LYS A 1 88 ? 47.403 37.017 -23.611 1.00 22.46 ? 144 LYS B C 1 ATOM 604 O O . LYS A 1 88 ? 46.386 36.327 -23.555 1.00 21.07 ? 144 LYS B O 1 ATOM 605 C CB . LYS A 1 88 ? 47.139 38.412 -25.643 1.00 37.42 ? 144 LYS B CB 1 ATOM 606 C CG . LYS A 1 88 ? 46.942 39.767 -26.304 1.00 43.32 ? 144 LYS B CG 1 ATOM 607 C CD . LYS A 1 88 ? 46.339 39.594 -27.683 1.00 49.98 ? 144 LYS B CD 1 ATOM 608 C CE . LYS A 1 88 ? 46.034 40.931 -28.333 1.00 59.17 ? 144 LYS B CE 1 ATOM 609 N NZ . LYS A 1 88 ? 47.264 41.742 -28.567 1.00 65.62 ? 144 LYS B NZ 1 ATOM 610 N N . THR A 1 89 ? 48.588 36.557 -23.247 1.00 23.42 ? 145 THR B N 1 ATOM 611 C CA . THR A 1 89 ? 48.727 35.167 -22.861 1.00 28.37 ? 145 THR B CA 1 ATOM 612 C C . THR A 1 89 ? 49.747 34.998 -21.761 1.00 33.40 ? 145 THR B C 1 ATOM 613 O O . THR A 1 89 ? 50.862 35.511 -21.846 1.00 36.11 ? 145 THR B O 1 ATOM 614 C CB . THR A 1 89 ? 49.116 34.299 -24.055 1.00 37.42 ? 145 THR B CB 1 ATOM 615 O OG1 . THR A 1 89 ? 48.037 34.288 -24.993 1.00 45.82 ? 145 THR B OG1 1 ATOM 616 C CG2 . THR A 1 89 ? 49.399 32.883 -23.615 1.00 40.57 ? 145 THR B CG2 1 ATOM 617 N N . LEU A 1 90 ? 49.357 34.265 -20.730 1.00 35.59 ? 146 LEU B N 1 ATOM 618 C CA . LEU A 1 90 ? 50.252 33.955 -19.640 1.00 35.53 ? 146 LEU B CA 1 ATOM 619 C C . LEU A 1 90 ? 50.151 32.472 -19.349 1.00 34.60 ? 146 LEU B C 1 ATOM 620 O O . LEU A 1 90 ? 49.088 31.994 -18.960 1.00 34.98 ? 146 LEU B O 1 ATOM 621 C CB . LEU A 1 90 ? 49.856 34.764 -18.406 1.00 33.73 ? 146 LEU B CB 1 ATOM 622 C CG . LEU A 1 90 ? 50.770 34.744 -17.181 1.00 25.28 ? 146 LEU B CG 1 ATOM 623 C CD1 . LEU A 1 90 ? 52.223 34.608 -17.575 1.00 26.65 ? 146 LEU B CD1 1 ATOM 624 C CD2 . LEU A 1 90 ? 50.570 36.030 -16.433 1.00 25.96 ? 146 LEU B CD2 1 ATOM 625 N N . SER A 1 91 ? 51.240 31.737 -19.561 1.00 35.30 ? 147 SER B N 1 ATOM 626 C CA . SER A 1 91 ? 51.273 30.339 -19.160 1.00 33.42 ? 147 SER B CA 1 ATOM 627 C C . SER A 1 91 ? 52.411 30.126 -18.173 1.00 37.62 ? 147 SER B C 1 ATOM 628 O O . SER A 1 91 ? 53.580 30.068 -18.557 1.00 42.07 ? 147 SER B O 1 ATOM 629 C CB . SER A 1 91 ? 51.481 29.453 -20.390 1.00 33.60 ? 147 SER B CB 1 ATOM 630 O OG . SER A 1 91 ? 50.742 29.938 -21.502 1.00 33.98 ? 147 SER B OG 1 ATOM 631 N N . LEU A 1 92 ? 52.050 30.007 -16.899 1.00 33.51 ? 148 LEU B N 1 ATOM 632 C CA . LEU A 1 92 ? 52.986 29.709 -15.818 1.00 32.46 ? 148 LEU B CA 1 ATOM 633 C C . LEU A 1 92 ? 52.897 28.244 -15.361 1.00 35.53 ? 148 LEU B C 1 ATOM 634 O O . LEU A 1 92 ? 53.533 27.837 -14.384 1.00 34.79 ? 148 LEU B O 1 ATOM 635 C CB . LEU A 1 92 ? 52.806 30.705 -14.659 1.00 34.33 ? 148 LEU B CB 1 ATOM 636 C CG . LEU A 1 92 ? 53.201 32.160 -14.980 1.00 37.24 ? 148 LEU B CG 1 ATOM 637 C CD1 . LEU A 1 92 ? 52.670 33.147 -13.961 1.00 26.72 ? 148 LEU B CD1 1 ATOM 638 C CD2 . LEU A 1 92 ? 54.698 32.321 -15.108 1.00 28.23 ? 148 LEU B CD2 1 ATOM 639 N N . ASN A 1 93 ? 52.066 27.478 -16.059 1.00 36.45 ? 149 ASN B N 1 ATOM 640 C CA . ASN A 1 93 ? 51.634 26.151 -15.619 1.00 36.48 ? 149 ASN B CA 1 ATOM 641 C C . ASN A 1 93 ? 52.706 25.069 -15.634 1.00 36.93 ? 149 ASN B C 1 ATOM 642 O O . ASN A 1 93 ? 53.709 25.184 -16.346 1.00 39.45 ? 149 ASN B O 1 ATOM 643 C CB . ASN A 1 93 ? 50.436 25.686 -16.456 1.00 37.16 ? 149 ASN B CB 1 ATOM 644 C CG . ASN A 1 93 ? 50.826 25.304 -17.881 1.00 38.93 ? 149 ASN B CG 1 ATOM 645 O OD1 . ASN A 1 93 ? 51.050 24.132 -18.179 1.00 19.87 ? 149 ASN B OD1 1 ATOM 646 N ND2 . ASN A 1 93 ? 50.906 26.296 -18.764 1.00 20.69 ? 149 ASN B ND2 1 ATOM 647 N N . THR A 1 94 ? 52.459 24.010 -14.860 1.00 32.67 ? 150 THR B N 1 ATOM 648 C CA . THR A 1 94 ? 53.356 22.865 -14.768 1.00 25.65 ? 150 THR B CA 1 ATOM 649 C C . THR A 1 94 ? 54.702 23.339 -14.235 1.00 29.54 ? 150 THR B C 1 ATOM 650 O O . THR A 1 94 ? 55.752 23.046 -14.804 1.00 32.30 ? 150 THR B O 1 ATOM 651 C CB . THR A 1 94 ? 53.534 22.154 -16.136 1.00 46.81 ? 150 THR B CB 1 ATOM 652 O OG1 . THR A 1 94 ? 52.282 22.119 -16.834 1.00 36.85 ? 150 THR B OG1 1 ATOM 653 C CG2 . THR A 1 94 ? 54.047 20.733 -15.953 1.00 53.50 ? 150 THR B CG2 1 ATOM 654 N N . ASN A 1 95 ? 54.647 24.112 -13.155 1.00 27.85 ? 151 ASN B N 1 ATOM 655 C CA . ASN A 1 95 ? 55.831 24.586 -12.459 1.00 25.55 ? 151 ASN B CA 1 ATOM 656 C C . ASN A 1 95 ? 55.608 24.474 -10.957 1.00 46.48 ? 151 ASN B C 1 ATOM 657 O O . ASN A 1 95 ? 54.595 23.943 -10.509 1.00 24.13 ? 151 ASN B O 1 ATOM 658 C CB . ASN A 1 95 ? 56.124 26.042 -12.822 1.00 43.18 ? 151 ASN B CB 1 ATOM 659 C CG . ASN A 1 95 ? 56.676 26.197 -14.221 1.00 47.01 ? 151 ASN B CG 1 ATOM 660 O OD1 . ASN A 1 95 ? 57.372 25.326 -14.724 1.00 49.83 ? 151 ASN B OD1 1 ATOM 661 N ND2 . ASN A 1 95 ? 56.366 27.315 -14.857 1.00 48.25 ? 151 ASN B ND2 1 ATOM 662 N N . ASN A 1 96 ? 56.567 24.949 -10.174 1.00 26.76 ? 152 ASN B N 1 ATOM 663 C CA . ASN A 1 96 ? 56.419 24.942 -8.728 1.00 31.67 ? 152 ASN B CA 1 ATOM 664 C C . ASN A 1 96 ? 56.002 26.246 -8.065 1.00 34.64 ? 152 ASN B C 1 ATOM 665 O O . ASN A 1 96 ? 55.964 26.331 -6.837 1.00 32.05 ? 152 ASN B O 1 ATOM 666 C CB . ASN A 1 96 ? 57.612 24.289 -8.044 1.00 31.05 ? 152 ASN B CB 1 ATOM 667 C CG . ASN A 1 96 ? 57.458 22.790 -7.967 1.00 37.48 ? 152 ASN B CG 1 ATOM 668 O OD1 . ASN A 1 96 ? 56.415 22.285 -7.538 1.00 38.13 ? 152 ASN B OD1 1 ATOM 669 N ND2 . ASN A 1 96 ? 58.475 22.064 -8.419 1.00 43.63 ? 152 ASN B ND2 1 ATOM 670 N N . LEU A 1 97 ? 55.686 27.246 -8.880 1.00 40.22 ? 153 LEU B N 1 ATOM 671 C CA . LEU A 1 97 ? 55.429 28.589 -8.373 1.00 42.18 ? 153 LEU B CA 1 ATOM 672 C C . LEU A 1 97 ? 54.461 28.561 -7.200 1.00 37.79 ? 153 LEU B C 1 ATOM 673 O O . LEU A 1 97 ? 53.430 27.894 -7.246 1.00 25.44 ? 153 LEU B O 1 ATOM 674 C CB . LEU A 1 97 ? 54.846 29.475 -9.474 1.00 36.49 ? 153 LEU B CB 1 ATOM 675 C CG . LEU A 1 97 ? 55.570 29.481 -10.813 1.00 36.93 ? 153 LEU B CG 1 ATOM 676 C CD1 . LEU A 1 97 ? 54.893 30.469 -11.742 1.00 43.79 ? 153 LEU B CD1 1 ATOM 677 C CD2 . LEU A 1 97 ? 57.034 29.822 -10.633 1.00 37.34 ? 153 LEU B CD2 1 ATOM 678 N N . GLU A 1 98 ? 54.828 29.256 -6.132 1.00 27.85 ? 154 GLU B N 1 ATOM 679 C CA . GLU A 1 98 ? 53.951 29.386 -4.978 1.00 42.91 ? 154 GLU B CA 1 ATOM 680 C C . GLU A 1 98 ? 53.497 30.826 -4.820 1.00 38.14 ? 154 GLU B C 1 ATOM 681 O O . GLU A 1 98 ? 53.856 31.686 -5.618 1.00 43.83 ? 154 GLU B O 1 ATOM 682 C CB . GLU A 1 98 ? 54.645 28.897 -3.706 1.00 45.73 ? 154 GLU B CB 1 ATOM 683 C CG . GLU A 1 98 ? 56.116 29.246 -3.630 1.00 54.56 ? 154 GLU B CG 1 ATOM 684 C CD . GLU A 1 98 ? 56.743 28.795 -2.335 1.00 65.36 ? 154 GLU B CD 1 ATOM 685 O OE1 . GLU A 1 98 ? 57.971 28.966 -2.182 1.00 72.60 ? 154 GLU B OE1 1 ATOM 686 O OE2 . GLU A 1 98 ? 56.007 28.275 -1.467 1.00 66.68 ? 154 GLU B OE2 1 ATOM 687 N N . GLY A 1 99 ? 52.699 31.087 -3.796 1.00 36.67 ? 155 GLY B N 1 ATOM 688 C CA . GLY A 1 99 ? 52.251 32.438 -3.533 1.00 27.61 ? 155 GLY B CA 1 ATOM 689 C C . GLY A 1 99 ? 50.797 32.660 -3.865 1.00 34.03 ? 155 GLY B C 1 ATOM 690 O O . GLY A 1 99 ? 50.152 31.828 -4.500 1.00 34.60 ? 155 GLY B O 1 ATOM 691 N N . HIS A 1 100 ? 50.271 33.793 -3.421 1.00 35.76 ? 156 HIS B N 1 ATOM 692 C CA . HIS A 1 100 ? 48.921 34.192 -3.781 1.00 44.36 ? 156 HIS B CA 1 ATOM 693 C C . HIS A 1 100 ? 48.877 34.631 -5.240 1.00 45.43 ? 156 HIS B C 1 ATOM 694 O O . HIS A 1 100 ? 49.910 34.923 -5.843 1.00 46.15 ? 156 HIS B O 1 ATOM 695 C CB . HIS A 1 100 ? 48.441 35.323 -2.865 1.00 49.12 ? 156 HIS B CB 1 ATOM 696 C CG . HIS A 1 100 ? 48.194 34.888 -1.451 1.00 52.24 ? 156 HIS B CG 1 ATOM 697 N ND1 . HIS A 1 100 ? 46.997 35.107 -0.806 1.00 53.02 ? 156 HIS B ND1 1 ATOM 698 C CD2 . HIS A 1 100 ? 48.985 34.235 -0.569 1.00 53.04 ? 156 HIS B CD2 1 ATOM 699 C CE1 . HIS A 1 100 ? 47.063 34.615 0.419 1.00 53.35 ? 156 HIS B CE1 1 ATOM 700 N NE2 . HIS A 1 100 ? 48.261 34.077 0.587 1.00 53.19 ? 156 HIS B NE2 1 ATOM 701 N N . ILE A 1 101 ? 47.688 34.647 -5.824 1.00 41.61 ? 157 ILE B N 1 ATOM 702 C CA . ILE A 1 101 ? 47.538 35.284 -7.121 1.00 38.13 ? 157 ILE B CA 1 ATOM 703 C C . ILE A 1 101 ? 47.354 36.777 -6.882 1.00 36.09 ? 157 ILE B C 1 ATOM 704 O O . ILE A 1 101 ? 46.379 37.198 -6.258 1.00 35.04 ? 157 ILE B O 1 ATOM 705 C CB . ILE A 1 101 ? 46.351 34.728 -7.901 1.00 38.78 ? 157 ILE B CB 1 ATOM 706 C CG1 . ILE A 1 101 ? 46.591 33.259 -8.250 1.00 37.66 ? 157 ILE B CG1 1 ATOM 707 C CG2 . ILE A 1 101 ? 46.140 35.539 -9.166 1.00 42.68 ? 157 ILE B CG2 1 ATOM 708 C CD1 . ILE A 1 101 ? 45.329 32.494 -8.566 1.00 31.95 ? 157 ILE B CD1 1 ATOM 709 N N . PRO A 1 102 ? 48.306 37.582 -7.362 1.00 35.62 ? 158 PRO B N 1 ATOM 710 C CA . PRO A 1 102 ? 48.311 39.022 -7.100 1.00 27.32 ? 158 PRO B CA 1 ATOM 711 C C . PRO A 1 102 ? 47.048 39.705 -7.594 1.00 36.90 ? 158 PRO B C 1 ATOM 712 O O . PRO A 1 102 ? 46.543 39.369 -8.660 1.00 45.25 ? 158 PRO B O 1 ATOM 713 C CB . PRO A 1 102 ? 49.524 39.507 -7.895 1.00 32.24 ? 158 PRO B CB 1 ATOM 714 C CG . PRO A 1 102 ? 50.405 38.318 -7.965 1.00 28.73 ? 158 PRO B CG 1 ATOM 715 C CD . PRO A 1 102 ? 49.479 37.169 -8.150 1.00 36.08 ? 158 PRO B CD 1 ATOM 716 N N . MET A 1 103 ? 46.548 40.652 -6.811 1.00 34.23 ? 159 MET B N 1 ATOM 717 C CA . MET A 1 103 ? 45.369 41.426 -7.174 1.00 36.72 ? 159 MET B CA 1 ATOM 718 C C . MET A 1 103 ? 45.629 42.215 -8.462 1.00 39.26 ? 159 MET B C 1 ATOM 719 O O . MET A 1 103 ? 44.748 42.358 -9.317 1.00 45.35 ? 159 MET B O 1 ATOM 720 C CB . MET A 1 103 ? 45.003 42.367 -6.022 1.00 35.26 ? 159 MET B CB 1 ATOM 721 C CG . MET A 1 103 ? 43.716 43.159 -6.200 1.00 38.57 ? 159 MET B CG 1 ATOM 722 S SD . MET A 1 103 ? 42.218 42.218 -5.837 1.00 134.43 ? 159 MET B SD 1 ATOM 723 C CE . MET A 1 103 ? 41.027 43.550 -5.648 1.00 36.11 ? 159 MET B CE 1 ATOM 724 N N . GLU A 1 104 ? 46.864 42.674 -8.624 1.00 32.89 ? 160 GLU B N 1 ATOM 725 C CA . GLU A 1 104 ? 47.235 43.511 -9.756 1.00 33.35 ? 160 GLU B CA 1 ATOM 726 C C . GLU A 1 104 ? 47.050 42.808 -11.092 1.00 42.09 ? 160 GLU B C 1 ATOM 727 O O . GLU A 1 104 ? 47.185 43.429 -12.147 1.00 50.03 ? 160 GLU B O 1 ATOM 728 C CB . GLU A 1 104 ? 48.670 44.017 -9.621 1.00 42.89 ? 160 GLU B CB 1 ATOM 729 C CG . GLU A 1 104 ? 48.851 45.080 -8.550 1.00 64.15 ? 160 GLU B CG 1 ATOM 730 C CD . GLU A 1 104 ? 48.790 44.507 -7.135 1.00 81.31 ? 160 GLU B CD 1 ATOM 731 O OE1 . GLU A 1 104 ? 48.987 43.280 -6.981 1.00 86.58 ? 160 GLU B OE1 1 ATOM 732 O OE2 . GLU A 1 104 ? 48.540 45.281 -6.178 1.00 86.33 ? 160 GLU B OE2 1 ATOM 733 N N . ILE A 1 105 ? 46.755 41.512 -11.054 1.00 42.40 ? 161 ILE B N 1 ATOM 734 C CA . ILE A 1 105 ? 46.428 40.776 -12.272 1.00 43.84 ? 161 ILE B CA 1 ATOM 735 C C . ILE A 1 105 ? 45.224 41.407 -12.988 1.00 47.05 ? 161 ILE B C 1 ATOM 736 O O . ILE A 1 105 ? 45.114 41.338 -14.214 1.00 43.53 ? 161 ILE B O 1 ATOM 737 C CB . ILE A 1 105 ? 46.163 39.282 -11.985 1.00 38.87 ? 161 ILE B CB 1 ATOM 738 C CG1 . ILE A 1 105 ? 46.323 38.449 -13.253 1.00 36.74 ? 161 ILE B CG1 1 ATOM 739 C CG2 . ILE A 1 105 ? 44.777 39.074 -11.394 1.00 38.67 ? 161 ILE B CG2 1 ATOM 740 C CD1 . ILE A 1 105 ? 46.307 36.957 -12.992 1.00 35.49 ? 161 ILE B CD1 1 ATOM 741 N N . GLY A 1 106 ? 44.340 42.047 -12.224 1.00 46.12 ? 162 GLY B N 1 ATOM 742 C CA . GLY A 1 106 ? 43.189 42.711 -12.811 1.00 43.03 ? 162 GLY B CA 1 ATOM 743 C C . GLY A 1 106 ? 43.588 43.859 -13.719 1.00 45.11 ? 162 GLY B C 1 ATOM 744 O O . GLY A 1 106 ? 42.794 44.310 -14.540 1.00 46.01 ? 162 GLY B O 1 ATOM 745 N N . ASN A 1 107 ? 44.825 44.330 -13.573 1.00 48.05 ? 163 ASN B N 1 ATOM 746 C CA . ASN A 1 107 ? 45.327 45.452 -14.367 1.00 55.45 ? 163 ASN B CA 1 ATOM 747 C C . ASN A 1 107 ? 45.715 45.076 -15.804 1.00 51.89 ? 163 ASN B C 1 ATOM 748 O O . ASN A 1 107 ? 46.043 45.953 -16.609 1.00 46.86 ? 163 ASN B O 1 ATOM 749 C CB . ASN A 1 107 ? 46.488 46.161 -13.654 1.00 67.10 ? 163 ASN B CB 1 ATOM 750 C CG . ASN A 1 107 ? 46.018 47.114 -12.554 1.00 75.79 ? 163 ASN B CG 1 ATOM 751 O OD1 . ASN A 1 107 ? 45.908 48.321 -12.770 1.00 77.04 ? 163 ASN B OD1 1 ATOM 752 N ND2 . ASN A 1 107 ? 45.745 46.570 -11.371 1.00 79.28 ? 163 ASN B ND2 1 ATOM 753 N N . LEU A 1 108 ? 45.668 43.787 -16.137 1.00 50.10 ? 164 LEU B N 1 ATOM 754 C CA . LEU A 1 108 ? 45.969 43.395 -17.505 1.00 44.77 ? 164 LEU B CA 1 ATOM 755 C C . LEU A 1 108 ? 44.682 43.345 -18.315 1.00 37.93 ? 164 LEU B C 1 ATOM 756 O O . LEU A 1 108 ? 43.987 42.325 -18.344 1.00 23.26 ? 164 LEU B O 1 ATOM 757 C CB . LEU A 1 108 ? 46.596 41.998 -17.517 1.00 42.61 ? 164 LEU B CB 1 ATOM 758 C CG . LEU A 1 108 ? 47.860 41.776 -16.696 1.00 26.91 ? 164 LEU B CG 1 ATOM 759 C CD1 . LEU A 1 108 ? 48.480 40.429 -17.024 1.00 26.57 ? 164 LEU B CD1 1 ATOM 760 C CD2 . LEU A 1 108 ? 48.844 42.896 -16.951 1.00 28.62 ? 164 LEU B CD2 1 ATOM 761 N N . SER A 1 109 ? 44.459 44.397 -19.092 1.00 30.05 ? 165 SER B N 1 ATOM 762 C CA . SER A 1 109 ? 43.200 44.569 -19.803 1.00 33.03 ? 165 SER B CA 1 ATOM 763 C C . SER A 1 109 ? 43.111 43.558 -20.927 1.00 35.10 ? 165 SER B C 1 ATOM 764 O O . SER A 1 109 ? 42.021 43.161 -21.330 1.00 31.09 ? 165 SER B O 1 ATOM 765 C CB . SER A 1 109 ? 43.102 45.977 -20.401 1.00 42.32 ? 165 SER B CB 1 ATOM 766 O OG . SER A 1 109 ? 43.418 46.979 -19.452 1.00 50.89 ? 165 SER B OG 1 ATOM 767 N N . GLY A 1 110 ? 44.267 43.141 -21.432 1.00 36.07 ? 166 GLY B N 1 ATOM 768 C CA . GLY A 1 110 ? 44.310 42.373 -22.657 1.00 32.64 ? 166 GLY B CA 1 ATOM 769 C C . GLY A 1 110 ? 44.560 40.891 -22.503 1.00 39.14 ? 166 GLY B C 1 ATOM 770 O O . GLY A 1 110 ? 44.746 40.200 -23.496 1.00 41.21 ? 166 GLY B O 1 ATOM 771 N N . LEU A 1 111 ? 44.556 40.388 -21.272 1.00 41.88 ? 167 LEU B N 1 ATOM 772 C CA . LEU A 1 111 ? 44.828 38.970 -21.054 1.00 29.37 ? 167 LEU B CA 1 ATOM 773 C C . LEU A 1 111 ? 43.681 38.111 -21.601 1.00 25.33 ? 167 LEU B C 1 ATOM 774 O O . LEU A 1 111 ? 42.514 38.305 -21.254 1.00 20.56 ? 167 LEU B O 1 ATOM 775 C CB . LEU A 1 111 ? 45.107 38.691 -19.576 1.00 21.78 ? 167 LEU B CB 1 ATOM 776 C CG . LEU A 1 111 ? 45.657 37.295 -19.255 1.00 32.90 ? 167 LEU B CG 1 ATOM 777 C CD1 . LEU A 1 111 ? 46.906 37.011 -20.077 1.00 28.99 ? 167 LEU B CD1 1 ATOM 778 C CD2 . LEU A 1 111 ? 45.945 37.131 -17.755 1.00 30.27 ? 167 LEU B CD2 1 ATOM 779 N N . VAL A 1 112 ? 44.033 37.170 -22.471 1.00 28.82 ? 168 VAL B N 1 ATOM 780 C CA . VAL A 1 112 ? 43.063 36.314 -23.158 1.00 29.42 ? 168 VAL B CA 1 ATOM 781 C C . VAL A 1 112 ? 43.051 34.900 -22.580 1.00 29.06 ? 168 VAL B C 1 ATOM 782 O O . VAL A 1 112 ? 41.999 34.372 -22.217 1.00 26.10 ? 168 VAL B O 1 ATOM 783 C CB . VAL A 1 112 ? 43.258 36.290 -24.700 1.00 17.96 ? 168 VAL B CB 1 ATOM 784 C CG1 . VAL A 1 112 ? 42.290 35.322 -25.335 1.00 16.47 ? 168 VAL B CG1 1 ATOM 785 C CG2 . VAL A 1 112 ? 43.049 37.669 -25.270 1.00 18.49 ? 168 VAL B CG2 1 ATOM 786 N N . GLU A 1 113 ? 44.210 34.258 -22.594 1.00 31.29 ? 169 GLU B N 1 ATOM 787 C CA . GLU A 1 113 ? 44.355 32.938 -22.003 1.00 30.95 ? 169 GLU B CA 1 ATOM 788 C C . GLU A 1 113 ? 45.296 32.961 -20.788 1.00 30.51 ? 169 GLU B C 1 ATOM 789 O O . GLU A 1 113 ? 46.443 33.382 -20.900 1.00 42.39 ? 169 GLU B O 1 ATOM 790 C CB . GLU A 1 113 ? 44.888 31.986 -23.064 1.00 32.66 ? 169 GLU B CB 1 ATOM 791 C CG . GLU A 1 113 ? 44.443 32.356 -24.461 1.00 38.43 ? 169 GLU B CG 1 ATOM 792 C CD . GLU A 1 113 ? 43.400 31.410 -25.015 1.00 47.23 ? 169 GLU B CD 1 ATOM 793 O OE1 . GLU A 1 113 ? 43.595 30.184 -24.880 1.00 52.15 ? 169 GLU B OE1 1 ATOM 794 O OE2 . GLU A 1 113 ? 42.390 31.887 -25.586 1.00 48.15 ? 169 GLU B OE2 1 ATOM 795 N N . LEU A 1 114 ? 44.812 32.506 -19.635 1.00 25.09 ? 170 LEU B N 1 ATOM 796 C CA . LEU A 1 114 ? 45.621 32.463 -18.411 1.00 23.73 ? 170 LEU B CA 1 ATOM 797 C C . LEU A 1 114 ? 45.767 31.045 -17.866 1.00 23.88 ? 170 LEU B C 1 ATOM 798 O O . LEU A 1 114 ? 44.787 30.470 -17.403 1.00 29.73 ? 170 LEU B O 1 ATOM 799 C CB . LEU A 1 114 ? 44.960 33.324 -17.345 1.00 23.75 ? 170 LEU B CB 1 ATOM 800 C CG . LEU A 1 114 ? 45.482 33.198 -15.921 1.00 26.51 ? 170 LEU B CG 1 ATOM 801 C CD1 . LEU A 1 114 ? 46.935 33.614 -15.878 1.00 26.19 ? 170 LEU B CD1 1 ATOM 802 C CD2 . LEU A 1 114 ? 44.636 34.046 -14.990 1.00 19.23 ? 170 LEU B CD2 1 ATOM 803 N N . MET A 1 115 ? 46.975 30.481 -17.917 1.00 23.97 ? 171 MET B N 1 ATOM 804 C CA . MET A 1 115 ? 47.191 29.114 -17.426 1.00 31.13 ? 171 MET B CA 1 ATOM 805 C C . MET A 1 115 ? 48.140 29.036 -16.225 1.00 34.59 ? 171 MET B C 1 ATOM 806 O O . MET A 1 115 ? 49.354 29.121 -16.384 1.00 37.59 ? 171 MET B O 1 ATOM 807 C CB . MET A 1 115 ? 47.775 28.252 -18.549 1.00 29.49 ? 171 MET B CB 1 ATOM 808 C CG . MET A 1 115 ? 47.159 28.486 -19.906 1.00 21.55 ? 171 MET B CG 1 ATOM 809 S SD . MET A 1 115 ? 45.744 27.433 -20.185 1.00 32.85 ? 171 MET B SD 1 ATOM 810 C CE . MET A 1 115 ? 45.239 27.955 -21.825 1.00 15.95 ? 171 MET B CE 1 ATOM 811 N N . LEU A 1 116 ? 47.580 28.843 -15.038 1.00 19.09 ? 172 LEU B N 1 ATOM 812 C CA . LEU A 1 116 ? 48.359 28.723 -13.799 1.00 24.58 ? 172 LEU B CA 1 ATOM 813 C C . LEU A 1 116 ? 48.487 27.293 -13.253 1.00 24.70 ? 172 LEU B C 1 ATOM 814 O O . LEU A 1 116 ? 49.117 27.063 -12.221 1.00 19.99 ? 172 LEU B O 1 ATOM 815 C CB . LEU A 1 116 ? 47.766 29.647 -12.734 1.00 20.00 ? 172 LEU B CB 1 ATOM 816 C CG . LEU A 1 116 ? 47.735 31.110 -13.181 1.00 23.09 ? 172 LEU B CG 1 ATOM 817 C CD1 . LEU A 1 116 ? 46.737 31.902 -12.366 1.00 28.50 ? 172 LEU B CD1 1 ATOM 818 C CD2 . LEU A 1 116 ? 49.125 31.732 -13.083 1.00 22.44 ? 172 LEU B CD2 1 ATOM 819 N N . PHE A 1 117 ? 47.864 26.344 -13.945 1.00 29.89 ? 173 PHE B N 1 ATOM 820 C CA . PHE A 1 117 ? 47.591 25.024 -13.380 1.00 17.37 ? 173 PHE B CA 1 ATOM 821 C C . PHE A 1 117 ? 48.817 24.145 -13.115 1.00 25.10 ? 173 PHE B C 1 ATOM 822 O O . PHE A 1 117 ? 49.896 24.392 -13.651 1.00 25.44 ? 173 PHE B O 1 ATOM 823 C CB . PHE A 1 117 ? 46.550 24.281 -14.222 1.00 15.95 ? 173 PHE B CB 1 ATOM 824 C CG . PHE A 1 117 ? 47.060 23.792 -15.548 1.00 16.06 ? 173 PHE B CG 1 ATOM 825 C CD1 . PHE A 1 117 ? 47.721 22.578 -15.650 1.00 23.28 ? 173 PHE B CD1 1 ATOM 826 C CD2 . PHE A 1 117 ? 46.839 24.527 -16.700 1.00 16.08 ? 173 PHE B CD2 1 ATOM 827 C CE1 . PHE A 1 117 ? 48.178 22.120 -16.868 1.00 17.43 ? 173 PHE B CE1 1 ATOM 828 C CE2 . PHE A 1 117 ? 47.289 24.074 -17.936 1.00 16.19 ? 173 PHE B CE2 1 ATOM 829 C CZ . PHE A 1 117 ? 47.956 22.871 -18.022 1.00 19.67 ? 173 PHE B CZ 1 ATOM 830 N N . ASP A 1 118 ? 48.628 23.125 -12.276 1.00 24.94 ? 174 ASP B N 1 ATOM 831 C CA . ASP A 1 118 ? 49.709 22.244 -11.816 1.00 21.96 ? 174 ASP B CA 1 ATOM 832 C C . ASP A 1 118 ? 50.886 23.031 -11.260 1.00 21.19 ? 174 ASP B C 1 ATOM 833 O O . ASP A 1 118 ? 51.969 23.016 -11.838 1.00 25.36 ? 174 ASP B O 1 ATOM 834 C CB . ASP A 1 118 ? 50.200 21.306 -12.923 1.00 24.55 ? 174 ASP B CB 1 ATOM 835 C CG . ASP A 1 118 ? 49.259 20.134 -13.170 1.00 29.72 ? 174 ASP B CG 1 ATOM 836 O OD1 . ASP A 1 118 ? 48.528 19.732 -12.245 1.00 25.82 ? 174 ASP B OD1 1 ATOM 837 O OD2 . ASP A 1 118 ? 49.260 19.603 -14.298 1.00 38.33 ? 174 ASP B OD2 1 ATOM 838 N N . ASN A 1 119 ? 50.656 23.723 -10.149 1.00 20.08 ? 175 ASN B N 1 ATOM 839 C CA . ASN A 1 119 ? 51.703 24.442 -9.444 1.00 21.56 ? 175 ASN B CA 1 ATOM 840 C C . ASN A 1 119 ? 51.582 24.142 -7.971 1.00 21.48 ? 175 ASN B C 1 ATOM 841 O O . ASN A 1 119 ? 50.792 23.290 -7.559 1.00 20.33 ? 175 ASN B O 1 ATOM 842 C CB . ASN A 1 119 ? 51.570 25.953 -9.635 1.00 39.41 ? 175 ASN B CB 1 ATOM 843 C CG . ASN A 1 119 ? 52.135 26.438 -10.955 1.00 41.14 ? 175 ASN B CG 1 ATOM 844 O OD1 . ASN A 1 119 ? 53.161 25.961 -11.415 1.00 23.56 ? 175 ASN B OD1 1 ATOM 845 N ND2 . ASN A 1 119 ? 51.465 27.405 -11.565 1.00 22.57 ? 175 ASN B ND2 1 ATOM 846 N N . LYS A 1 120 ? 52.399 24.831 -7.184 1.00 32.33 ? 176 LYS B N 1 ATOM 847 C CA . LYS A 1 120 ? 52.315 24.819 -5.728 1.00 33.39 ? 176 LYS B CA 1 ATOM 848 C C . LYS A 1 120 ? 51.531 26.007 -5.139 1.00 38.30 ? 176 LYS B C 1 ATOM 849 O O . LYS A 1 120 ? 51.575 26.237 -3.939 1.00 46.03 ? 176 LYS B O 1 ATOM 850 C CB . LYS A 1 120 ? 53.696 24.646 -5.090 1.00 33.30 ? 176 LYS B CB 1 ATOM 851 C CG . LYS A 1 120 ? 54.074 23.182 -4.878 1.00 34.62 ? 176 LYS B CG 1 ATOM 852 C CD . LYS A 1 120 ? 52.987 22.468 -4.066 1.00 44.82 ? 176 LYS B CD 1 ATOM 853 C CE . LYS A 1 120 ? 53.388 21.049 -3.627 1.00 48.95 ? 176 LYS B CE 1 ATOM 854 N NZ . LYS A 1 120 ? 54.425 21.002 -2.536 1.00 47.25 ? 176 LYS B NZ 1 ATOM 855 N N . LEU A 1 121 ? 50.841 26.769 -5.987 1.00 39.36 ? 177 LEU B N 1 ATOM 856 C CA . LEU A 1 121 ? 50.214 28.033 -5.579 1.00 36.01 ? 177 LEU B CA 1 ATOM 857 C C . LEU A 1 121 ? 49.208 27.866 -4.441 1.00 32.51 ? 177 LEU B C 1 ATOM 858 O O . LEU A 1 121 ? 48.692 26.773 -4.196 1.00 31.30 ? 177 LEU B O 1 ATOM 859 C CB . LEU A 1 121 ? 49.479 28.679 -6.764 1.00 40.59 ? 177 LEU B CB 1 ATOM 860 C CG . LEU A 1 121 ? 50.224 29.139 -8.025 1.00 41.76 ? 177 LEU B CG 1 ATOM 861 C CD1 . LEU A 1 121 ? 49.245 29.697 -9.065 1.00 39.30 ? 177 LEU B CD1 1 ATOM 862 C CD2 . LEU A 1 121 ? 51.287 30.174 -7.680 1.00 41.08 ? 177 LEU B CD2 1 ATOM 863 N N . SER A 1 122 ? 48.967 28.967 -3.733 1.00 35.39 ? 178 SER B N 1 ATOM 864 C CA . SER A 1 122 ? 48.043 29.015 -2.601 1.00 35.55 ? 178 SER B CA 1 ATOM 865 C C . SER A 1 122 ? 47.342 30.372 -2.549 1.00 33.86 ? 178 SER B C 1 ATOM 866 O O . SER A 1 122 ? 47.491 31.198 -3.452 1.00 44.75 ? 178 SER B O 1 ATOM 867 C CB . SER A 1 122 ? 48.792 28.775 -1.286 1.00 39.23 ? 178 SER B CB 1 ATOM 868 O OG . SER A 1 122 ? 49.889 29.668 -1.140 1.00 24.05 ? 178 SER B OG 1 ATOM 869 N N . GLY A 1 123 ? 46.581 30.598 -1.486 1.00 25.07 ? 179 GLY B N 1 ATOM 870 C CA . GLY A 1 123 ? 45.874 31.854 -1.311 1.00 28.80 ? 179 GLY B CA 1 ATOM 871 C C . GLY A 1 123 ? 44.475 31.803 -1.881 1.00 31.62 ? 179 GLY B C 1 ATOM 872 O O . GLY A 1 123 ? 43.995 30.740 -2.251 1.00 35.34 ? 179 GLY B O 1 ATOM 873 N N . GLU A 1 124 ? 43.810 32.948 -1.951 1.00 35.30 ? 180 GLU B N 1 ATOM 874 C CA . GLU A 1 124 ? 42.511 33.008 -2.608 1.00 33.43 ? 180 GLU B CA 1 ATOM 875 C C . GLU A 1 124 ? 42.662 33.448 -4.061 1.00 28.24 ? 180 GLU B C 1 ATOM 876 O O . GLU A 1 124 ? 43.755 33.809 -4.514 1.00 22.74 ? 180 GLU B O 1 ATOM 877 C CB . GLU A 1 124 ? 41.596 34.006 -1.895 1.00 38.82 ? 180 GLU B CB 1 ATOM 878 C CG . GLU A 1 124 ? 40.906 33.502 -0.644 1.00 45.39 ? 180 GLU B CG 1 ATOM 879 C CD . GLU A 1 124 ? 39.692 34.347 -0.306 1.00 55.70 ? 180 GLU B CD 1 ATOM 880 O OE1 . GLU A 1 124 ? 39.573 35.457 -0.868 1.00 56.75 ? 180 GLU B OE1 1 ATOM 881 O OE2 . GLU A 1 124 ? 38.852 33.900 0.505 1.00 61.59 ? 180 GLU B OE2 1 ATOM 882 N N . ILE A 1 125 ? 41.542 33.440 -4.775 1.00 30.36 ? 181 ILE B N 1 ATOM 883 C CA . ILE A 1 125 ? 41.478 34.027 -6.100 1.00 32.16 ? 181 ILE B CA 1 ATOM 884 C C . ILE A 1 125 ? 41.109 35.475 -5.892 1.00 30.36 ? 181 ILE B C 1 ATOM 885 O O . ILE A 1 125 ? 40.092 35.769 -5.270 1.00 34.29 ? 181 ILE B O 1 ATOM 886 C CB . ILE A 1 125 ? 40.399 33.370 -6.977 1.00 32.36 ? 181 ILE B CB 1 ATOM 887 C CG1 . ILE A 1 125 ? 40.797 31.946 -7.344 1.00 32.84 ? 181 ILE B CG1 1 ATOM 888 C CG2 . ILE A 1 125 ? 40.205 34.157 -8.257 1.00 34.35 ? 181 ILE B CG2 1 ATOM 889 C CD1 . ILE A 1 125 ? 39.828 31.290 -8.298 1.00 37.83 ? 181 ILE B CD1 1 ATOM 890 N N . PRO A 1 126 ? 41.942 36.387 -6.395 1.00 28.84 ? 182 PRO B N 1 ATOM 891 C CA . PRO A 1 126 ? 41.697 37.822 -6.236 1.00 20.60 ? 182 PRO B CA 1 ATOM 892 C C . PRO A 1 126 ? 40.350 38.191 -6.805 1.00 21.39 ? 182 PRO B C 1 ATOM 893 O O . PRO A 1 126 ? 39.920 37.547 -7.750 1.00 25.33 ? 182 PRO B O 1 ATOM 894 C CB . PRO A 1 126 ? 42.812 38.464 -7.066 1.00 38.89 ? 182 PRO B CB 1 ATOM 895 C CG . PRO A 1 126 ? 43.332 37.372 -7.951 1.00 34.19 ? 182 PRO B CG 1 ATOM 896 C CD . PRO A 1 126 ? 43.159 36.113 -7.171 1.00 28.65 ? 182 PRO B CD 1 ATOM 897 N N . ARG A 1 127 ? 39.690 39.194 -6.239 1.00 26.47 ? 183 ARG B N 1 ATOM 898 C CA . ARG A 1 127 ? 38.390 39.630 -6.745 1.00 26.47 ? 183 ARG B CA 1 ATOM 899 C C . ARG A 1 127 ? 38.555 40.398 -8.053 1.00 26.44 ? 183 ARG B C 1 ATOM 900 O O . ARG A 1 127 ? 37.567 40.765 -8.681 1.00 32.94 ? 183 ARG B O 1 ATOM 901 C CB . ARG A 1 127 ? 37.657 40.518 -5.724 1.00 30.74 ? 183 ARG B CB 1 ATOM 902 C CG . ARG A 1 127 ? 38.096 40.375 -4.270 1.00 33.55 ? 183 ARG B CG 1 ATOM 903 C CD . ARG A 1 127 ? 37.171 39.463 -3.473 1.00 37.50 ? 183 ARG B CD 1 ATOM 904 N NE . ARG A 1 127 ? 35.782 39.915 -3.497 1.00 41.23 ? 183 ARG B NE 1 ATOM 905 C CZ . ARG A 1 127 ? 35.317 40.943 -2.796 1.00 47.63 ? 183 ARG B CZ 1 ATOM 906 N NH1 . ARG A 1 127 ? 36.130 41.640 -2.014 1.00 55.45 ? 183 ARG B NH1 1 ATOM 907 N NH2 . ARG A 1 127 ? 34.037 41.277 -2.882 1.00 43.91 ? 183 ARG B NH2 1 ATOM 908 N N . SER A 1 128 ? 39.807 40.651 -8.436 1.00 27.08 ? 184 SER B N 1 ATOM 909 C CA . SER A 1 128 ? 40.158 41.431 -9.632 1.00 29.48 ? 184 SER B CA 1 ATOM 910 C C . SER A 1 128 ? 40.031 40.726 -10.990 1.00 24.93 ? 184 SER B C 1 ATOM 911 O O . SER A 1 128 ? 40.136 41.380 -12.021 1.00 20.37 ? 184 SER B O 1 ATOM 912 C CB . SER A 1 128 ? 41.586 41.951 -9.515 1.00 22.56 ? 184 SER B CB 1 ATOM 913 O OG . SER A 1 128 ? 41.651 43.045 -8.637 1.00 72.57 ? 184 SER B OG 1 ATOM 914 N N . ILE A 1 129 ? 39.840 39.409 -11.003 1.00 20.09 ? 185 ILE B N 1 ATOM 915 C CA . ILE A 1 129 ? 39.671 38.687 -12.261 1.00 24.90 ? 185 ILE B CA 1 ATOM 916 C C . ILE A 1 129 ? 38.498 39.257 -13.063 1.00 32.16 ? 185 ILE B C 1 ATOM 917 O O . ILE A 1 129 ? 38.426 39.078 -14.273 1.00 35.58 ? 185 ILE B O 1 ATOM 918 C CB . ILE A 1 129 ? 39.466 37.159 -12.046 1.00 37.74 ? 185 ILE B CB 1 ATOM 919 C CG1 . ILE A 1 129 ? 39.024 36.871 -10.610 1.00 33.67 ? 185 ILE B CG1 1 ATOM 920 C CG2 . ILE A 1 129 ? 40.739 36.363 -12.383 1.00 17.59 ? 185 ILE B CG2 1 ATOM 921 C CD1 . ILE A 1 129 ? 37.607 37.325 -10.272 1.00 29.05 ? 185 ILE B CD1 1 ATOM 922 N N . GLY A 1 130 ? 37.589 39.953 -12.387 1.00 17.20 ? 186 GLY B N 1 ATOM 923 C CA . GLY A 1 130 ? 36.445 40.557 -13.050 1.00 20.01 ? 186 GLY B CA 1 ATOM 924 C C . GLY A 1 130 ? 36.791 41.783 -13.884 1.00 22.28 ? 186 GLY B C 1 ATOM 925 O O . GLY A 1 130 ? 35.998 42.242 -14.711 1.00 21.87 ? 186 GLY B O 1 ATOM 926 N N . GLU A 1 131 ? 37.979 42.328 -13.654 1.00 28.43 ? 187 GLU B N 1 ATOM 927 C CA . GLU A 1 131 ? 38.484 43.446 -14.440 1.00 32.50 ? 187 GLU B CA 1 ATOM 928 C C . GLU A 1 131 ? 38.980 42.974 -15.813 1.00 37.58 ? 187 GLU B C 1 ATOM 929 O O . GLU A 1 131 ? 39.173 43.786 -16.719 1.00 44.88 ? 187 GLU B O 1 ATOM 930 C CB . GLU A 1 131 ? 39.598 44.179 -13.683 1.00 36.39 ? 187 GLU B CB 1 ATOM 931 C CG . GLU A 1 131 ? 39.104 45.001 -12.495 1.00 45.16 ? 187 GLU B CG 1 ATOM 932 C CD . GLU A 1 131 ? 40.198 45.853 -11.866 1.00 59.96 ? 187 GLU B CD 1 ATOM 933 O OE1 . GLU A 1 131 ? 41.213 46.114 -12.549 1.00 69.14 ? 187 GLU B OE1 1 ATOM 934 O OE2 . GLU A 1 131 ? 40.044 46.261 -10.689 1.00 59.74 ? 187 GLU B OE2 1 ATOM 935 N N . LEU A 1 132 ? 39.155 41.664 -15.978 1.00 31.12 ? 188 LEU B N 1 ATOM 936 C CA . LEU A 1 132 ? 39.668 41.143 -17.229 1.00 29.42 ? 188 LEU B CA 1 ATOM 937 C C . LEU A 1 132 ? 38.466 40.833 -18.100 1.00 29.35 ? 188 LEU B C 1 ATOM 938 O O . LEU A 1 132 ? 37.804 39.812 -17.924 1.00 27.63 ? 188 LEU B O 1 ATOM 939 C CB . LEU A 1 132 ? 40.419 39.841 -16.963 1.00 18.66 ? 188 LEU B CB 1 ATOM 940 C CG . LEU A 1 132 ? 41.449 39.828 -15.837 1.00 19.76 ? 188 LEU B CG 1 ATOM 941 C CD1 . LEU A 1 132 ? 41.843 38.414 -15.488 1.00 26.81 ? 188 LEU B CD1 1 ATOM 942 C CD2 . LEU A 1 132 ? 42.665 40.589 -16.248 1.00 21.27 ? 188 LEU B CD2 1 ATOM 943 N N . LYS A 1 133 ? 38.212 41.690 -19.081 1.00 27.32 ? 189 LYS B N 1 ATOM 944 C CA . LYS A 1 133 ? 36.963 41.594 -19.810 1.00 19.46 ? 189 LYS B CA 1 ATOM 945 C C . LYS A 1 133 ? 37.080 40.719 -21.033 1.00 29.29 ? 189 LYS B C 1 ATOM 946 O O . LYS A 1 133 ? 36.077 40.235 -21.559 1.00 39.99 ? 189 LYS B O 1 ATOM 947 C CB . LYS A 1 133 ? 36.488 42.986 -20.202 1.00 20.75 ? 189 LYS B CB 1 ATOM 948 C CG . LYS A 1 133 ? 35.969 43.822 -19.033 1.00 31.54 ? 189 LYS B CG 1 ATOM 949 C CD . LYS A 1 133 ? 34.691 43.215 -18.473 1.00 39.42 ? 189 LYS B CD 1 ATOM 950 C CE . LYS A 1 133 ? 33.937 44.184 -17.573 1.00 44.48 ? 189 LYS B CE 1 ATOM 951 N NZ . LYS A 1 133 ? 34.613 44.397 -16.269 1.00 49.01 ? 189 LYS B NZ 1 ATOM 952 N N . ASN A 1 134 ? 38.312 40.511 -21.477 1.00 33.39 ? 190 ASN B N 1 ATOM 953 C CA . ASN A 1 134 ? 38.591 39.671 -22.639 1.00 38.89 ? 190 ASN B CA 1 ATOM 954 C C . ASN A 1 134 ? 39.107 38.267 -22.295 1.00 39.54 ? 190 ASN B C 1 ATOM 955 O O . ASN A 1 134 ? 39.476 37.504 -23.188 1.00 42.23 ? 190 ASN B O 1 ATOM 956 C CB . ASN A 1 134 ? 39.511 40.391 -23.625 1.00 50.45 ? 190 ASN B CB 1 ATOM 957 C CG . ASN A 1 134 ? 40.878 40.646 -23.048 1.00 75.76 ? 190 ASN B CG 1 ATOM 958 O OD1 . ASN A 1 134 ? 41.070 40.614 -21.819 1.00 88.79 ? 190 ASN B OD1 1 ATOM 959 N ND2 . ASN A 1 134 ? 41.851 40.895 -23.924 1.00 82.12 ? 190 ASN B ND2 1 ATOM 960 N N . LEU A 1 135 ? 39.169 37.945 -21.003 1.00 40.69 ? 191 LEU B N 1 ATOM 961 C CA . LEU A 1 135 ? 39.634 36.631 -20.564 1.00 15.47 ? 191 LEU B CA 1 ATOM 962 C C . LEU A 1 135 ? 38.698 35.545 -21.049 1.00 21.65 ? 191 LEU B C 1 ATOM 963 O O . LEU A 1 135 ? 37.479 35.689 -21.005 1.00 23.59 ? 191 LEU B O 1 ATOM 964 C CB . LEU A 1 135 ? 39.763 36.563 -19.047 1.00 19.99 ? 191 LEU B CB 1 ATOM 965 C CG . LEU A 1 135 ? 40.482 35.337 -18.477 1.00 15.76 ? 191 LEU B CG 1 ATOM 966 C CD1 . LEU A 1 135 ? 41.890 35.208 -19.036 1.00 16.83 ? 191 LEU B CD1 1 ATOM 967 C CD2 . LEU A 1 135 ? 40.519 35.413 -16.953 1.00 18.47 ? 191 LEU B CD2 1 ATOM 968 N N . GLN A 1 136 ? 39.296 34.452 -21.505 1.00 20.18 ? 192 GLN B N 1 ATOM 969 C CA . GLN A 1 136 ? 38.602 33.375 -22.200 1.00 19.03 ? 192 GLN B CA 1 ATOM 970 C C . GLN A 1 136 ? 38.819 32.041 -21.511 1.00 19.45 ? 192 GLN B C 1 ATOM 971 O O . GLN A 1 136 ? 37.878 31.301 -21.239 1.00 20.59 ? 192 GLN B O 1 ATOM 972 C CB . GLN A 1 136 ? 39.039 33.304 -23.658 1.00 20.70 ? 192 GLN B CB 1 ATOM 973 C CG . GLN A 1 136 ? 38.199 34.156 -24.571 1.00 12.38 ? 192 GLN B CG 1 ATOM 974 C CD . GLN A 1 136 ? 38.757 34.196 -25.968 1.00 22.17 ? 192 GLN B CD 1 ATOM 975 O OE1 . GLN A 1 136 ? 39.235 33.189 -26.485 1.00 29.21 ? 192 GLN B OE1 1 ATOM 976 N NE2 . GLN A 1 136 ? 38.709 35.361 -26.586 1.00 13.21 ? 192 GLN B NE2 1 ATOM 977 N N . VAL A 1 137 ? 40.087 31.688 -21.357 1.00 18.05 ? 193 VAL B N 1 ATOM 978 C CA . VAL A 1 137 ? 40.460 30.505 -20.610 1.00 16.58 ? 193 VAL B CA 1 ATOM 979 C C . VAL A 1 137 ? 41.166 30.872 -19.312 1.00 18.52 ? 193 VAL B C 1 ATOM 980 O O . VAL A 1 137 ? 42.198 31.533 -19.305 1.00 16.47 ? 193 VAL B O 1 ATOM 981 C CB . VAL A 1 137 ? 41.336 29.573 -21.458 1.00 17.90 ? 193 VAL B CB 1 ATOM 982 C CG1 . VAL A 1 137 ? 41.882 28.425 -20.625 1.00 16.85 ? 193 VAL B CG1 1 ATOM 983 C CG2 . VAL A 1 137 ? 40.522 29.048 -22.612 1.00 23.01 ? 193 VAL B CG2 1 ATOM 984 N N . LEU A 1 138 ? 40.577 30.452 -18.205 1.00 22.01 ? 194 LEU B N 1 ATOM 985 C CA . LEU A 1 138 ? 41.254 30.519 -16.927 1.00 21.80 ? 194 LEU B CA 1 ATOM 986 C C . LEU A 1 138 ? 41.357 29.104 -16.432 1.00 16.33 ? 194 LEU B C 1 ATOM 987 O O . LEU A 1 138 ? 40.344 28.475 -16.152 1.00 12.27 ? 194 LEU B O 1 ATOM 988 C CB . LEU A 1 138 ? 40.454 31.365 -15.937 1.00 23.63 ? 194 LEU B CB 1 ATOM 989 C CG . LEU A 1 138 ? 40.741 31.206 -14.448 1.00 20.21 ? 194 LEU B CG 1 ATOM 990 C CD1 . LEU A 1 138 ? 42.191 31.497 -14.113 1.00 23.10 ? 194 LEU B CD1 1 ATOM 991 C CD2 . LEU A 1 138 ? 39.826 32.132 -13.697 1.00 23.29 ? 194 LEU B CD2 1 ATOM 992 N N . ARG A 1 139 ? 42.574 28.584 -16.367 1.00 19.72 ? 195 ARG B N 1 ATOM 993 C CA . ARG A 1 139 ? 42.774 27.282 -15.762 1.00 25.73 ? 195 ARG B CA 1 ATOM 994 C C . ARG A 1 139 ? 43.877 27.328 -14.719 1.00 27.58 ? 195 ARG B C 1 ATOM 995 O O . ARG A 1 139 ? 45.064 27.380 -15.071 1.00 15.99 ? 195 ARG B O 1 ATOM 996 C CB . ARG A 1 139 ? 43.127 26.283 -16.859 1.00 13.51 ? 195 ARG B CB 1 ATOM 997 C CG . ARG A 1 139 ? 41.961 25.974 -17.740 1.00 12.25 ? 195 ARG B CG 1 ATOM 998 C CD . ARG A 1 139 ? 42.336 24.995 -18.803 1.00 17.12 ? 195 ARG B CD 1 ATOM 999 N NE . ARG A 1 139 ? 43.034 23.825 -18.287 1.00 17.64 ? 195 ARG B NE 1 ATOM 1000 C CZ . ARG A 1 139 ? 43.569 22.905 -19.080 1.00 17.55 ? 195 ARG B CZ 1 ATOM 1001 N NH1 . ARG A 1 139 ? 44.200 21.859 -18.571 1.00 16.98 ? 195 ARG B NH1 1 ATOM 1002 N NH2 . ARG A 1 139 ? 43.472 23.046 -20.393 1.00 12.04 ? 195 ARG B NH2 1 ATOM 1003 N N . ALA A 1 140 ? 43.452 27.323 -13.448 1.00 23.04 ? 196 ALA B N 1 ATOM 1004 C CA . ALA A 1 140 ? 44.324 27.316 -12.263 1.00 19.44 ? 196 ALA B CA 1 ATOM 1005 C C . ALA A 1 140 ? 44.386 26.038 -11.428 1.00 30.79 ? 196 ALA B C 1 ATOM 1006 O O . ALA A 1 140 ? 45.035 26.019 -10.384 1.00 40.37 ? 196 ALA B O 1 ATOM 1007 C CB . ALA A 1 140 ? 44.043 28.513 -11.386 1.00 16.15 ? 196 ALA B CB 1 ATOM 1008 N N . GLY A 1 141 ? 43.685 24.992 -11.845 1.00 34.05 ? 197 GLY B N 1 ATOM 1009 C CA . GLY A 1 141 ? 43.549 23.802 -11.017 1.00 27.45 ? 197 GLY B CA 1 ATOM 1010 C C . GLY A 1 141 ? 44.858 23.074 -10.773 1.00 28.91 ? 197 GLY B C 1 ATOM 1011 O O . GLY A 1 141 ? 45.902 23.476 -11.275 1.00 38.08 ? 197 GLY B O 1 ATOM 1012 N N . GLY A 1 142 ? 44.818 22.003 -9.988 1.00 22.48 ? 198 GLY B N 1 ATOM 1013 C CA . GLY A 1 142 ? 46.041 21.298 -9.651 1.00 19.49 ? 198 GLY B CA 1 ATOM 1014 C C . GLY A 1 142 ? 46.951 22.149 -8.778 1.00 21.01 ? 198 GLY B C 1 ATOM 1015 O O . GLY A 1 142 ? 48.181 22.037 -8.843 1.00 18.38 ? 198 GLY B O 1 ATOM 1016 N N . ASN A 1 143 ? 46.337 23.034 -7.993 1.00 15.94 ? 199 ASN B N 1 ATOM 1017 C CA . ASN A 1 143 ? 46.997 23.704 -6.884 1.00 17.03 ? 199 ASN B CA 1 ATOM 1018 C C . ASN A 1 143 ? 46.222 23.322 -5.645 1.00 23.77 ? 199 ASN B C 1 ATOM 1019 O O . ASN A 1 143 ? 45.098 23.790 -5.456 1.00 25.15 ? 199 ASN B O 1 ATOM 1020 C CB . ASN A 1 143 ? 46.928 25.225 -7.034 1.00 17.71 ? 199 ASN B CB 1 ATOM 1021 C CG . ASN A 1 143 ? 47.783 25.748 -8.174 1.00 36.96 ? 199 ASN B CG 1 ATOM 1022 O OD1 . ASN A 1 143 ? 48.868 25.239 -8.440 1.00 36.51 ? 199 ASN B OD1 1 ATOM 1023 N ND2 . ASN A 1 143 ? 47.294 26.779 -8.849 1.00 37.01 ? 199 ASN B ND2 1 ATOM 1024 N N . LYS A 1 144 ? 46.815 22.504 -4.779 1.00 23.92 ? 200 LYS B N 1 ATOM 1025 C CA . LYS A 1 144 ? 46.055 21.949 -3.665 1.00 24.26 ? 200 LYS B CA 1 ATOM 1026 C C . LYS A 1 144 ? 45.657 22.984 -2.616 1.00 21.90 ? 200 LYS B C 1 ATOM 1027 O O . LYS A 1 144 ? 44.666 22.794 -1.906 1.00 17.42 ? 200 LYS B O 1 ATOM 1028 C CB . LYS A 1 144 ? 46.785 20.766 -3.020 1.00 27.04 ? 200 LYS B CB 1 ATOM 1029 C CG . LYS A 1 144 ? 45.865 19.830 -2.240 1.00 32.29 ? 200 LYS B CG 1 ATOM 1030 C CD . LYS A 1 144 ? 46.380 18.389 -2.256 1.00 36.92 ? 200 LYS B CD 1 ATOM 1031 C CE . LYS A 1 144 ? 46.114 17.675 -0.922 1.00 37.08 ? 200 LYS B CE 1 ATOM 1032 N NZ . LYS A 1 144 ? 44.677 17.689 -0.478 1.00 34.38 ? 200 LYS B NZ 1 ATOM 1033 N N . ASN A 1 145 ? 46.428 24.061 -2.498 1.00 17.41 ? 201 ASN B N 1 ATOM 1034 C CA . ASN A 1 145 ? 46.124 25.070 -1.481 1.00 38.44 ? 201 ASN B CA 1 ATOM 1035 C C . ASN A 1 145 ? 45.406 26.329 -1.933 1.00 44.88 ? 201 ASN B C 1 ATOM 1036 O O . ASN A 1 145 ? 45.108 27.195 -1.112 1.00 51.61 ? 201 ASN B O 1 ATOM 1037 C CB . ASN A 1 145 ? 47.355 25.401 -0.642 1.00 34.39 ? 201 ASN B CB 1 ATOM 1038 C CG . ASN A 1 145 ? 47.722 24.271 0.280 1.00 30.41 ? 201 ASN B CG 1 ATOM 1039 O OD1 . ASN A 1 145 ? 46.869 23.755 1.010 1.00 18.31 ? 201 ASN B OD1 1 ATOM 1040 N ND2 . ASN A 1 145 ? 48.975 23.838 0.220 1.00 29.38 ? 201 ASN B ND2 1 ATOM 1041 N N . LEU A 1 146 ? 45.144 26.430 -3.233 1.00 43.90 ? 202 LEU B N 1 ATOM 1042 C CA . LEU A 1 146 ? 44.342 27.523 -3.763 1.00 37.89 ? 202 LEU B CA 1 ATOM 1043 C C . LEU A 1 146 ? 42.941 27.341 -3.191 1.00 35.59 ? 202 LEU B C 1 ATOM 1044 O O . LEU A 1 146 ? 42.321 26.289 -3.365 1.00 33.63 ? 202 LEU B O 1 ATOM 1045 C CB . LEU A 1 146 ? 44.334 27.475 -5.301 1.00 35.96 ? 202 LEU B CB 1 ATOM 1046 C CG . LEU A 1 146 ? 43.993 28.724 -6.127 1.00 28.72 ? 202 LEU B CG 1 ATOM 1047 C CD1 . LEU A 1 146 ? 42.502 28.985 -6.160 1.00 15.92 ? 202 LEU B CD1 1 ATOM 1048 C CD2 . LEU A 1 146 ? 44.730 29.937 -5.595 1.00 30.36 ? 202 LEU B CD2 1 ATOM 1049 N N . ARG A 1 147 ? 42.438 28.372 -2.522 1.00 16.23 ? 203 ARG B N 1 ATOM 1050 C CA . ARG A 1 147 ? 41.257 28.222 -1.683 1.00 39.80 ? 203 ARG B CA 1 ATOM 1051 C C . ARG A 1 147 ? 40.356 29.445 -1.656 1.00 34.72 ? 203 ARG B C 1 ATOM 1052 O O . ARG A 1 147 ? 40.546 30.408 -2.406 1.00 37.54 ? 203 ARG B O 1 ATOM 1053 C CB . ARG A 1 147 ? 41.673 27.883 -0.246 1.00 41.15 ? 203 ARG B CB 1 ATOM 1054 C CG . ARG A 1 147 ? 42.516 28.967 0.430 1.00 50.01 ? 203 ARG B CG 1 ATOM 1055 C CD . ARG A 1 147 ? 42.892 28.589 1.864 1.00 62.90 ? 203 ARG B CD 1 ATOM 1056 N NE . ARG A 1 147 ? 41.721 28.492 2.735 1.00 66.13 ? 203 ARG B NE 1 ATOM 1057 C CZ . ARG A 1 147 ? 41.273 29.476 3.509 1.00 60.12 ? 203 ARG B CZ 1 ATOM 1058 N NH1 . ARG A 1 147 ? 41.903 30.642 3.540 1.00 60.49 ? 203 ARG B NH1 1 ATOM 1059 N NH2 . ARG A 1 147 ? 40.195 29.292 4.257 1.00 60.79 ? 203 ARG B NH2 1 ATOM 1060 N N . GLY A 1 148 ? 39.371 29.390 -0.765 1.00 24.68 ? 204 GLY B N 1 ATOM 1061 C CA . GLY A 1 148 ? 38.396 30.450 -0.629 1.00 15.80 ? 204 GLY B CA 1 ATOM 1062 C C . GLY A 1 148 ? 37.203 30.237 -1.528 1.00 19.07 ? 204 GLY B C 1 ATOM 1063 O O . GLY A 1 148 ? 37.179 29.320 -2.355 1.00 24.73 ? 204 GLY B O 1 ATOM 1064 N N . GLU A 1 149 ? 36.193 31.079 -1.353 1.00 19.96 ? 205 GLU B N 1 ATOM 1065 C CA . GLU A 1 149 ? 35.055 31.077 -2.257 1.00 22.21 ? 205 GLU B CA 1 ATOM 1066 C C . GLU A 1 149 ? 35.489 31.525 -3.665 1.00 24.21 ? 205 GLU B C 1 ATOM 1067 O O . GLU A 1 149 ? 36.486 32.226 -3.829 1.00 17.08 ? 205 GLU B O 1 ATOM 1068 C CB . GLU A 1 149 ? 33.940 31.979 -1.713 1.00 18.32 ? 205 GLU B CB 1 ATOM 1069 C CG . GLU A 1 149 ? 33.281 31.468 -0.440 1.00 20.55 ? 205 GLU B CG 1 ATOM 1070 C CD . GLU A 1 149 ? 31.763 31.605 -0.454 1.00 41.83 ? 205 GLU B CD 1 ATOM 1071 O OE1 . GLU A 1 149 ? 31.147 31.569 0.627 1.00 49.75 ? 205 GLU B OE1 1 ATOM 1072 O OE2 . GLU A 1 149 ? 31.177 31.733 -1.546 1.00 55.25 ? 205 GLU B OE2 1 ATOM 1073 N N . LEU A 1 150 ? 34.755 31.101 -4.687 1.00 28.94 ? 206 LEU B N 1 ATOM 1074 C CA . LEU A 1 150 ? 34.997 31.622 -6.023 1.00 23.98 ? 206 LEU B CA 1 ATOM 1075 C C . LEU A 1 150 ? 34.427 33.035 -6.022 1.00 22.32 ? 206 LEU B C 1 ATOM 1076 O O . LEU A 1 150 ? 33.251 33.226 -5.709 1.00 23.27 ? 206 LEU B O 1 ATOM 1077 C CB . LEU A 1 150 ? 34.327 30.736 -7.077 1.00 22.83 ? 206 LEU B CB 1 ATOM 1078 C CG . LEU A 1 150 ? 34.525 31.050 -8.567 1.00 32.70 ? 206 LEU B CG 1 ATOM 1079 C CD1 . LEU A 1 150 ? 35.996 31.054 -8.956 1.00 33.41 ? 206 LEU B CD1 1 ATOM 1080 C CD2 . LEU A 1 150 ? 33.747 30.069 -9.437 1.00 31.08 ? 206 LEU B CD2 1 ATOM 1081 N N . PRO A 1 151 ? 35.265 34.036 -6.341 1.00 22.50 ? 207 PRO B N 1 ATOM 1082 C CA . PRO A 1 151 ? 34.830 35.436 -6.242 1.00 13.46 ? 207 PRO B CA 1 ATOM 1083 C C . PRO A 1 151 ? 33.580 35.720 -7.056 1.00 17.83 ? 207 PRO B C 1 ATOM 1084 O O . PRO A 1 151 ? 33.349 35.077 -8.065 1.00 28.74 ? 207 PRO B O 1 ATOM 1085 C CB . PRO A 1 151 ? 36.026 36.225 -6.792 1.00 22.34 ? 207 PRO B CB 1 ATOM 1086 C CG . PRO A 1 151 ? 36.875 35.228 -7.507 1.00 14.65 ? 207 PRO B CG 1 ATOM 1087 C CD . PRO A 1 151 ? 36.657 33.923 -6.812 1.00 19.63 ? 207 PRO B CD 1 ATOM 1088 N N . TRP A 1 152 ? 32.779 36.668 -6.598 1.00 12.60 ? 208 TRP B N 1 ATOM 1089 C CA . TRP A 1 152 ? 31.529 37.013 -7.247 1.00 25.40 ? 208 TRP B CA 1 ATOM 1090 C C . TRP A 1 152 ? 31.862 37.617 -8.610 1.00 27.06 ? 208 TRP B C 1 ATOM 1091 O O . TRP A 1 152 ? 31.259 37.290 -9.648 1.00 32.75 ? 208 TRP B O 1 ATOM 1092 C CB . TRP A 1 152 ? 30.776 38.022 -6.372 1.00 12.04 ? 208 TRP B CB 1 ATOM 1093 C CG . TRP A 1 152 ? 29.491 38.484 -6.954 1.00 28.72 ? 208 TRP B CG 1 ATOM 1094 C CD1 . TRP A 1 152 ? 29.274 39.625 -7.692 1.00 28.17 ? 208 TRP B CD1 1 ATOM 1095 C CD2 . TRP A 1 152 ? 28.230 37.816 -6.865 1.00 25.07 ? 208 TRP B CD2 1 ATOM 1096 N NE1 . TRP A 1 152 ? 27.949 39.703 -8.063 1.00 22.18 ? 208 TRP B NE1 1 ATOM 1097 C CE2 . TRP A 1 152 ? 27.288 38.606 -7.570 1.00 23.08 ? 208 TRP B CE2 1 ATOM 1098 C CE3 . TRP A 1 152 ? 27.805 36.624 -6.268 1.00 22.63 ? 208 TRP B CE3 1 ATOM 1099 C CZ2 . TRP A 1 152 ? 25.942 38.236 -7.684 1.00 20.04 ? 208 TRP B CZ2 1 ATOM 1100 C CZ3 . TRP A 1 152 ? 26.470 36.260 -6.383 1.00 20.88 ? 208 TRP B CZ3 1 ATOM 1101 C CH2 . TRP A 1 152 ? 25.553 37.068 -7.083 1.00 18.53 ? 208 TRP B CH2 1 ATOM 1102 N N . GLU A 1 153 ? 32.892 38.452 -8.595 1.00 24.36 ? 209 GLU B N 1 ATOM 1103 C CA . GLU A 1 153 ? 33.308 39.240 -9.739 1.00 23.64 ? 209 GLU B CA 1 ATOM 1104 C C . GLU A 1 153 ? 33.675 38.390 -10.955 1.00 25.88 ? 209 GLU B C 1 ATOM 1105 O O . GLU A 1 153 ? 33.829 38.919 -12.057 1.00 25.05 ? 209 GLU B O 1 ATOM 1106 C CB . GLU A 1 153 ? 34.494 40.112 -9.337 1.00 26.01 ? 209 GLU B CB 1 ATOM 1107 C CG . GLU A 1 153 ? 34.181 41.137 -8.248 1.00 35.49 ? 209 GLU B CG 1 ATOM 1108 C CD . GLU A 1 153 ? 34.057 40.548 -6.851 1.00 38.82 ? 209 GLU B CD 1 ATOM 1109 O OE1 . GLU A 1 153 ? 33.930 39.314 -6.710 1.00 37.97 ? 209 GLU B OE1 1 ATOM 1110 O OE2 . GLU A 1 153 ? 34.085 41.335 -5.885 1.00 44.85 ? 209 GLU B OE2 1 ATOM 1111 N N . ILE A 1 154 ? 33.818 37.081 -10.760 1.00 24.77 ? 210 ILE B N 1 ATOM 1112 C CA . ILE A 1 154 ? 34.052 36.166 -11.875 1.00 19.84 ? 210 ILE B CA 1 ATOM 1113 C C . ILE A 1 154 ? 32.961 36.265 -12.945 1.00 19.66 ? 210 ILE B C 1 ATOM 1114 O O . ILE A 1 154 ? 33.209 35.972 -14.111 1.00 22.01 ? 210 ILE B O 1 ATOM 1115 C CB . ILE A 1 154 ? 34.186 34.696 -11.407 1.00 17.08 ? 210 ILE B CB 1 ATOM 1116 C CG1 . ILE A 1 154 ? 34.818 33.838 -12.502 1.00 11.26 ? 210 ILE B CG1 1 ATOM 1117 C CG2 . ILE A 1 154 ? 32.830 34.128 -10.998 1.00 16.68 ? 210 ILE B CG2 1 ATOM 1118 C CD1 . ILE A 1 154 ? 36.059 34.430 -13.102 1.00 14.65 ? 210 ILE B CD1 1 ATOM 1119 N N . GLY A 1 155 ? 31.765 36.703 -12.555 1.00 22.75 ? 211 GLY B N 1 ATOM 1120 C CA . GLY A 1 155 ? 30.674 36.828 -13.508 1.00 18.26 ? 211 GLY B CA 1 ATOM 1121 C C . GLY A 1 155 ? 30.917 37.968 -14.484 1.00 19.28 ? 211 GLY B C 1 ATOM 1122 O O . GLY A 1 155 ? 30.221 38.113 -15.488 1.00 14.01 ? 211 GLY B O 1 ATOM 1123 N N . ASN A 1 156 ? 31.914 38.791 -14.188 1.00 21.79 ? 212 ASN B N 1 ATOM 1124 C CA . ASN A 1 156 ? 32.234 39.915 -15.046 1.00 22.62 ? 212 ASN B CA 1 ATOM 1125 C C . ASN A 1 156 ? 33.172 39.548 -16.182 1.00 32.85 ? 212 ASN B C 1 ATOM 1126 O O . ASN A 1 156 ? 33.429 40.383 -17.051 1.00 46.08 ? 212 ASN B O 1 ATOM 1127 C CB . ASN A 1 156 ? 32.812 41.083 -14.241 1.00 25.84 ? 212 ASN B CB 1 ATOM 1128 C CG . ASN A 1 156 ? 31.790 41.713 -13.307 1.00 25.22 ? 212 ASN B CG 1 ATOM 1129 O OD1 . ASN A 1 156 ? 30.656 41.988 -13.698 1.00 22.13 ? 212 ASN B OD1 1 ATOM 1130 N ND2 . ASN A 1 156 ? 32.190 41.937 -12.058 1.00 28.30 ? 212 ASN B ND2 1 ATOM 1131 N N . CYS A 1 157 ? 33.663 38.309 -16.227 1.00 27.96 ? 213 CYS B N 1 ATOM 1132 C CA . CYS A 1 157 ? 34.515 37.966 -17.362 1.00 31.51 ? 213 CYS B CA 1 ATOM 1133 C C . CYS A 1 157 ? 33.559 37.477 -18.421 1.00 34.53 ? 213 CYS B C 1 ATOM 1134 O O . CYS A 1 157 ? 33.160 36.313 -18.435 1.00 37.89 ? 213 CYS B O 1 ATOM 1135 C CB . CYS A 1 157 ? 35.458 36.828 -16.996 1.00 26.33 ? 213 CYS B CB 1 ATOM 1136 S SG . CYS A 1 157 ? 36.388 37.113 -15.494 1.00 23.40 ? 213 CYS B SG 1 ATOM 1137 N N . GLU A 1 158 ? 33.270 38.353 -19.367 1.00 31.93 ? 214 GLU B N 1 ATOM 1138 C CA . GLU A 1 158 ? 32.106 38.159 -20.202 1.00 40.64 ? 214 GLU B CA 1 ATOM 1139 C C . GLU A 1 158 ? 32.399 37.159 -21.307 1.00 40.17 ? 214 GLU B C 1 ATOM 1140 O O . GLU A 1 158 ? 31.497 36.474 -21.790 1.00 43.24 ? 214 GLU B O 1 ATOM 1141 C CB . GLU A 1 158 ? 31.640 39.500 -20.776 1.00 55.04 ? 214 GLU B CB 1 ATOM 1142 C CG . GLU A 1 158 ? 32.783 40.411 -21.198 1.00 60.25 ? 214 GLU B CG 1 ATOM 1143 C CD . GLU A 1 158 ? 32.322 41.608 -22.001 1.00 63.44 ? 214 GLU B CD 1 ATOM 1144 O OE1 . GLU A 1 158 ? 31.494 41.434 -22.924 1.00 61.28 ? 214 GLU B OE1 1 ATOM 1145 O OE2 . GLU A 1 158 ? 32.798 42.725 -21.711 1.00 68.33 ? 214 GLU B OE2 1 ATOM 1146 N N . ASN A 1 159 ? 33.667 37.075 -21.699 1.00 33.58 ? 215 ASN B N 1 ATOM 1147 C CA . ASN A 1 159 ? 34.070 36.228 -22.814 1.00 21.79 ? 215 ASN B CA 1 ATOM 1148 C C . ASN A 1 159 ? 34.554 34.851 -22.400 1.00 12.44 ? 215 ASN B C 1 ATOM 1149 O O . ASN A 1 159 ? 35.084 34.097 -23.218 1.00 10.00 ? 215 ASN B O 1 ATOM 1150 C CB . ASN A 1 159 ? 35.109 36.928 -23.682 1.00 27.42 ? 215 ASN B CB 1 ATOM 1151 C CG . ASN A 1 159 ? 34.568 38.192 -24.331 1.00 25.37 ? 215 ASN B CG 1 ATOM 1152 O OD1 . ASN A 1 159 ? 33.438 38.624 -24.060 1.00 11.08 ? 215 ASN B OD1 1 ATOM 1153 N ND2 . ASN A 1 159 ? 35.384 38.805 -25.176 1.00 24.24 ? 215 ASN B ND2 1 ATOM 1154 N N . LEU A 1 160 ? 34.400 34.543 -21.120 1.00 18.53 ? 216 LEU B N 1 ATOM 1155 C CA . LEU A 1 160 ? 34.828 33.262 -20.586 1.00 12.84 ? 216 LEU B CA 1 ATOM 1156 C C . LEU A 1 160 ? 34.235 32.089 -21.346 1.00 16.20 ? 216 LEU B C 1 ATOM 1157 O O . LEU A 1 160 ? 33.078 32.096 -21.771 1.00 19.68 ? 216 LEU B O 1 ATOM 1158 C CB . LEU A 1 160 ? 34.490 33.143 -19.099 1.00 15.10 ? 216 LEU B CB 1 ATOM 1159 C CG . LEU A 1 160 ? 35.646 33.221 -18.096 1.00 19.86 ? 216 LEU B CG 1 ATOM 1160 C CD1 . LEU A 1 160 ? 35.140 32.890 -16.707 1.00 20.21 ? 216 LEU B CD1 1 ATOM 1161 C CD2 . LEU A 1 160 ? 36.795 32.301 -18.459 1.00 11.03 ? 216 LEU B CD2 1 ATOM 1162 N N . VAL A 1 161 ? 35.082 31.088 -21.510 1.00 20.29 ? 217 VAL B N 1 ATOM 1163 C CA . VAL A 1 161 ? 34.835 29.903 -22.319 1.00 22.77 ? 217 VAL B CA 1 ATOM 1164 C C . VAL A 1 161 ? 35.176 28.654 -21.489 1.00 21.23 ? 217 VAL B C 1 ATOM 1165 O O . VAL A 1 161 ? 34.453 27.655 -21.516 1.00 19.20 ? 217 VAL B O 1 ATOM 1166 C CB . VAL A 1 161 ? 35.516 29.999 -23.723 1.00 9.89 ? 217 VAL B CB 1 ATOM 1167 C CG1 . VAL A 1 161 ? 36.246 28.739 -24.086 1.00 8.17 ? 217 VAL B CG1 1 ATOM 1168 C CG2 . VAL A 1 161 ? 34.472 30.340 -24.773 1.00 12.23 ? 217 VAL B CG2 1 ATOM 1169 N N . MET A 1 162 ? 36.358 28.684 -20.880 1.00 8.57 ? 218 MET B N 1 ATOM 1170 C CA . MET A 1 162 ? 36.834 27.613 -20.014 1.00 14.20 ? 218 MET B CA 1 ATOM 1171 C C . MET A 1 162 ? 37.199 28.082 -18.578 1.00 18.37 ? 218 MET B C 1 ATOM 1172 O O . MET A 1 162 ? 38.083 28.920 -18.354 1.00 15.16 ? 218 MET B O 1 ATOM 1173 C CB . MET A 1 162 ? 38.021 26.902 -20.673 1.00 9.08 ? 218 MET B CB 1 ATOM 1174 C CG . MET A 1 162 ? 38.854 26.087 -19.712 1.00 9.48 ? 218 MET B CG 1 ATOM 1175 S SD . MET A 1 162 ? 38.279 24.396 -19.612 1.00 17.45 ? 218 MET B SD 1 ATOM 1176 C CE . MET A 1 162 ? 38.792 23.962 -17.945 1.00 25.10 ? 218 MET B CE 1 ATOM 1177 N N . LEU A 1 163 ? 36.499 27.539 -17.598 1.00 8.52 ? 219 LEU B N 1 ATOM 1178 C CA . LEU A 1 163 ? 36.872 27.788 -16.216 1.00 14.67 ? 219 LEU B CA 1 ATOM 1179 C C . LEU A 1 163 ? 37.202 26.464 -15.582 1.00 8.81 ? 219 LEU B C 1 ATOM 1180 O O . LEU A 1 163 ? 36.332 25.611 -15.455 1.00 7.75 ? 219 LEU B O 1 ATOM 1181 C CB . LEU A 1 163 ? 35.724 28.446 -15.445 1.00 14.15 ? 219 LEU B CB 1 ATOM 1182 C CG . LEU A 1 163 ? 35.921 28.725 -13.949 1.00 12.50 ? 219 LEU B CG 1 ATOM 1183 C CD1 . LEU A 1 163 ? 37.023 29.751 -13.727 1.00 17.70 ? 219 LEU B CD1 1 ATOM 1184 C CD2 . LEU A 1 163 ? 34.620 29.218 -13.330 1.00 8.49 ? 219 LEU B CD2 1 ATOM 1185 N N . GLY A 1 164 ? 38.445 26.257 -15.191 1.00 9.75 ? 220 GLY B N 1 ATOM 1186 C CA . GLY A 1 164 ? 38.595 25.182 -14.257 1.00 18.23 ? 220 GLY B CA 1 ATOM 1187 C C . GLY A 1 164 ? 39.679 25.243 -13.222 1.00 23.34 ? 220 GLY B C 1 ATOM 1188 O O . GLY A 1 164 ? 40.862 25.486 -13.439 1.00 26.73 ? 220 GLY B O 1 ATOM 1189 N N . LEU A 1 165 ? 39.141 24.951 -12.049 1.00 25.55 ? 221 LEU B N 1 ATOM 1190 C CA . LEU A 1 165 ? 39.748 24.965 -10.742 1.00 15.50 ? 221 LEU B CA 1 ATOM 1191 C C . LEU A 1 165 ? 39.890 23.562 -10.167 1.00 14.13 ? 221 LEU B C 1 ATOM 1192 O O . LEU A 1 165 ? 39.916 23.406 -8.957 1.00 22.44 ? 221 LEU B O 1 ATOM 1193 C CB . LEU A 1 165 ? 38.995 25.929 -9.829 1.00 10.78 ? 221 LEU B CB 1 ATOM 1194 C CG . LEU A 1 165 ? 38.934 27.336 -10.450 1.00 11.34 ? 221 LEU B CG 1 ATOM 1195 C CD1 . LEU A 1 165 ? 37.934 28.202 -9.726 1.00 13.86 ? 221 LEU B CD1 1 ATOM 1196 C CD2 . LEU A 1 165 ? 40.299 28.021 -10.469 1.00 12.81 ? 221 LEU B CD2 1 ATOM 1197 N N . ALA A 1 166 ? 39.782 22.541 -11.010 1.00 13.23 ? 222 ALA B N 1 ATOM 1198 C CA . ALA A 1 166 ? 39.760 21.166 -10.525 1.00 9.09 ? 222 ALA B CA 1 ATOM 1199 C C . ALA A 1 166 ? 40.945 20.842 -9.618 1.00 27.97 ? 222 ALA B C 1 ATOM 1200 O O . ALA A 1 166 ? 42.036 21.405 -9.764 1.00 11.18 ? 222 ALA B O 1 ATOM 1201 C CB . ALA A 1 166 ? 39.711 20.201 -11.677 1.00 41.62 ? 222 ALA B CB 1 ATOM 1202 N N . GLU A 1 167 ? 40.701 19.963 -8.654 1.00 9.58 ? 223 GLU B N 1 ATOM 1203 C CA . GLU A 1 167 ? 41.734 19.540 -7.714 1.00 21.78 ? 223 GLU B CA 1 ATOM 1204 C C . GLU A 1 167 ? 42.358 20.685 -6.906 1.00 16.99 ? 223 GLU B C 1 ATOM 1205 O O . GLU A 1 167 ? 43.568 20.695 -6.658 1.00 16.37 ? 223 GLU B O 1 ATOM 1206 C CB . GLU A 1 167 ? 42.806 18.723 -8.421 1.00 10.85 ? 223 GLU B CB 1 ATOM 1207 C CG . GLU A 1 167 ? 42.350 17.349 -8.784 1.00 57.97 ? 223 GLU B CG 1 ATOM 1208 C CD . GLU A 1 167 ? 43.176 16.291 -8.112 1.00 60.66 ? 223 GLU B CD 1 ATOM 1209 O OE1 . GLU A 1 167 ? 44.361 16.573 -7.810 1.00 66.39 ? 223 GLU B OE1 1 ATOM 1210 O OE2 . GLU A 1 167 ? 42.640 15.185 -7.877 1.00 59.10 ? 223 GLU B OE2 1 ATOM 1211 N N . THR A 1 168 ? 41.529 21.639 -6.493 1.00 13.25 ? 224 THR B N 1 ATOM 1212 C CA . THR A 1 168 ? 41.976 22.682 -5.574 1.00 22.43 ? 224 THR B CA 1 ATOM 1213 C C . THR A 1 168 ? 41.203 22.608 -4.265 1.00 26.37 ? 224 THR B C 1 ATOM 1214 O O . THR A 1 168 ? 40.350 21.734 -4.087 1.00 21.51 ? 224 THR B O 1 ATOM 1215 C CB . THR A 1 168 ? 41.798 24.088 -6.160 1.00 12.76 ? 224 THR B CB 1 ATOM 1216 O OG1 . THR A 1 168 ? 40.403 24.377 -6.312 1.00 11.71 ? 224 THR B OG1 1 ATOM 1217 C CG2 . THR A 1 168 ? 42.508 24.196 -7.494 1.00 13.20 ? 224 THR B CG2 1 ATOM 1218 N N . SER A 1 169 ? 41.513 23.524 -3.351 1.00 12.71 ? 225 SER B N 1 ATOM 1219 C CA . SER A 1 169 ? 40.839 23.576 -2.053 1.00 27.32 ? 225 SER B CA 1 ATOM 1220 C C . SER A 1 169 ? 39.695 24.558 -2.063 1.00 11.98 ? 225 SER B C 1 ATOM 1221 O O . SER A 1 169 ? 39.127 24.869 -1.024 1.00 58.55 ? 225 SER B O 1 ATOM 1222 C CB . SER A 1 169 ? 41.819 23.902 -0.926 1.00 13.61 ? 225 SER B CB 1 ATOM 1223 O OG . SER A 1 169 ? 42.694 22.810 -0.724 1.00 24.24 ? 225 SER B OG 1 ATOM 1224 N N . LEU A 1 170 ? 39.403 25.066 -3.251 1.00 23.52 ? 226 LEU B N 1 ATOM 1225 C CA . LEU A 1 170 ? 38.351 26.047 -3.470 1.00 17.68 ? 226 LEU B CA 1 ATOM 1226 C C . LEU A 1 170 ? 37.098 25.559 -2.788 1.00 14.39 ? 226 LEU B C 1 ATOM 1227 O O . LEU A 1 170 ? 36.809 24.358 -2.809 1.00 13.16 ? 226 LEU B O 1 ATOM 1228 C CB . LEU A 1 170 ? 38.074 26.170 -4.970 1.00 10.98 ? 226 LEU B CB 1 ATOM 1229 C CG . LEU A 1 170 ? 37.250 27.388 -5.354 1.00 16.39 ? 226 LEU B CG 1 ATOM 1230 C CD1 . LEU A 1 170 ? 38.103 28.390 -6.117 1.00 15.81 ? 226 LEU B CD1 1 ATOM 1231 C CD2 . LEU A 1 170 ? 36.023 26.983 -6.138 1.00 15.88 ? 226 LEU B CD2 1 ATOM 1232 N N . SER A 1 171 ? 36.371 26.471 -2.152 1.00 10.36 ? 227 SER B N 1 ATOM 1233 C CA . SER A 1 171 ? 35.244 26.055 -1.322 1.00 27.12 ? 227 SER B CA 1 ATOM 1234 C C . SER A 1 171 ? 34.102 27.029 -1.407 1.00 31.76 ? 227 SER B C 1 ATOM 1235 O O . SER A 1 171 ? 34.173 28.031 -2.119 1.00 43.19 ? 227 SER B O 1 ATOM 1236 C CB . SER A 1 171 ? 35.658 25.962 0.140 1.00 22.86 ? 227 SER B CB 1 ATOM 1237 O OG . SER A 1 171 ? 35.410 27.201 0.774 1.00 19.57 ? 227 SER B OG 1 ATOM 1238 N N . GLY A 1 172 ? 33.051 26.731 -0.657 1.00 8.36 ? 228 GLY B N 1 ATOM 1239 C CA . GLY A 1 172 ? 31.867 27.567 -0.630 1.00 14.39 ? 228 GLY B CA 1 ATOM 1240 C C . GLY A 1 172 ? 30.853 27.157 -1.671 1.00 11.76 ? 228 GLY B C 1 ATOM 1241 O O . GLY A 1 172 ? 30.858 26.022 -2.129 1.00 17.33 ? 228 GLY B O 1 ATOM 1242 N N . LYS A 1 173 ? 29.983 28.089 -2.042 1.00 15.15 ? 229 LYS B N 1 ATOM 1243 C CA . LYS A 1 173 ? 29.045 27.885 -3.139 1.00 13.35 ? 229 LYS B CA 1 ATOM 1244 C C . LYS A 1 173 ? 29.516 28.618 -4.415 1.00 21.62 ? 229 LYS B C 1 ATOM 1245 O O . LYS A 1 173 ? 30.128 29.692 -4.347 1.00 26.40 ? 229 LYS B O 1 ATOM 1246 C CB . LYS A 1 173 ? 27.647 28.368 -2.740 1.00 13.56 ? 229 LYS B CB 1 ATOM 1247 C CG . LYS A 1 173 ? 27.442 29.881 -2.896 1.00 27.62 ? 229 LYS B CG 1 ATOM 1248 C CD . LYS A 1 173 ? 25.978 30.307 -2.755 1.00 33.00 ? 229 LYS B CD 1 ATOM 1249 C CE . LYS A 1 173 ? 25.594 30.607 -1.305 1.00 29.13 ? 229 LYS B CE 1 ATOM 1250 N NZ . LYS A 1 173 ? 25.566 29.374 -0.487 1.00 28.22 ? 229 LYS B NZ 1 ATOM 1251 N N . LEU A 1 174 ? 29.259 28.018 -5.573 1.00 17.02 ? 230 LEU B N 1 ATOM 1252 C CA . LEU A 1 174 ? 29.396 28.734 -6.825 1.00 17.26 ? 230 LEU B CA 1 ATOM 1253 C C . LEU A 1 174 ? 28.441 29.907 -6.726 1.00 18.33 ? 230 LEU B C 1 ATOM 1254 O O . LEU A 1 174 ? 27.278 29.729 -6.363 1.00 18.42 ? 230 LEU B O 1 ATOM 1255 C CB . LEU A 1 174 ? 28.956 27.867 -8.004 1.00 26.25 ? 230 LEU B CB 1 ATOM 1256 C CG . LEU A 1 174 ? 29.548 26.484 -8.237 1.00 25.97 ? 230 LEU B CG 1 ATOM 1257 C CD1 . LEU A 1 174 ? 28.710 25.796 -9.276 1.00 22.47 ? 230 LEU B CD1 1 ATOM 1258 C CD2 . LEU A 1 174 ? 30.981 26.598 -8.698 1.00 32.90 ? 230 LEU B CD2 1 ATOM 1259 N N . PRO A 1 175 ? 28.923 31.115 -7.045 1.00 17.84 ? 231 PRO B N 1 ATOM 1260 C CA . PRO A 1 175 ? 28.071 32.297 -6.888 1.00 17.21 ? 231 PRO B CA 1 ATOM 1261 C C . PRO A 1 175 ? 27.016 32.349 -7.967 1.00 25.80 ? 231 PRO B C 1 ATOM 1262 O O . PRO A 1 175 ? 27.197 31.731 -9.013 1.00 27.58 ? 231 PRO B O 1 ATOM 1263 C CB . PRO A 1 175 ? 29.051 33.460 -7.026 1.00 7.95 ? 231 PRO B CB 1 ATOM 1264 C CG . PRO A 1 175 ? 30.222 32.903 -7.744 1.00 10.65 ? 231 PRO B CG 1 ATOM 1265 C CD . PRO A 1 175 ? 30.295 31.449 -7.462 1.00 11.50 ? 231 PRO B CD 1 ATOM 1266 N N . ALA A 1 176 ? 25.928 33.075 -7.723 1.00 31.29 ? 232 ALA B N 1 ATOM 1267 C CA . ALA A 1 176 ? 24.882 33.228 -8.734 1.00 25.34 ? 232 ALA B CA 1 ATOM 1268 C C . ALA A 1 176 ? 25.415 34.027 -9.927 1.00 25.54 ? 232 ALA B C 1 ATOM 1269 O O . ALA A 1 176 ? 24.799 34.069 -10.990 1.00 28.95 ? 232 ALA B O 1 ATOM 1270 C CB . ALA A 1 176 ? 23.633 33.891 -8.127 1.00 16.32 ? 232 ALA B CB 1 ATOM 1271 N N . SER A 1 177 ? 26.586 34.625 -9.730 1.00 25.82 ? 233 SER B N 1 ATOM 1272 C CA . SER A 1 177 ? 27.322 35.365 -10.743 1.00 26.09 ? 233 SER B CA 1 ATOM 1273 C C . SER A 1 177 ? 27.467 34.581 -12.043 1.00 30.41 ? 233 SER B C 1 ATOM 1274 O O . SER A 1 177 ? 27.581 35.166 -13.119 1.00 32.85 ? 233 SER B O 1 ATOM 1275 C CB . SER A 1 177 ? 28.730 35.644 -10.208 1.00 29.79 ? 233 SER B CB 1 ATOM 1276 O OG . SER A 1 177 ? 28.827 36.917 -9.610 1.00 39.82 ? 233 SER B OG 1 ATOM 1277 N N . ILE A 1 178 ? 27.474 33.255 -11.932 1.00 30.28 ? 234 ILE B N 1 ATOM 1278 C CA . ILE A 1 178 ? 27.702 32.379 -13.076 1.00 27.23 ? 234 ILE B CA 1 ATOM 1279 C C . ILE A 1 178 ? 26.559 32.492 -14.101 1.00 27.66 ? 234 ILE B C 1 ATOM 1280 O O . ILE A 1 178 ? 26.697 32.122 -15.264 1.00 26.37 ? 234 ILE B O 1 ATOM 1281 C CB . ILE A 1 178 ? 28.058 30.920 -12.632 1.00 29.98 ? 234 ILE B CB 1 ATOM 1282 C CG1 . ILE A 1 178 ? 29.532 30.825 -12.259 1.00 29.39 ? 234 ILE B CG1 1 ATOM 1283 C CG2 . ILE A 1 178 ? 27.916 29.934 -13.754 1.00 41.60 ? 234 ILE B CG2 1 ATOM 1284 C CD1 . ILE A 1 178 ? 29.905 31.539 -11.012 1.00 42.87 ? 234 ILE B CD1 1 ATOM 1285 N N . GLY A 1 179 ? 25.449 33.078 -13.673 1.00 30.70 ? 235 GLY B N 1 ATOM 1286 C CA . GLY A 1 179 ? 24.378 33.413 -14.588 1.00 27.85 ? 235 GLY B CA 1 ATOM 1287 C C . GLY A 1 179 ? 24.845 34.294 -15.734 1.00 24.09 ? 235 GLY B C 1 ATOM 1288 O O . GLY A 1 179 ? 24.269 34.260 -16.832 1.00 21.66 ? 235 GLY B O 1 ATOM 1289 N N . ASN A 1 180 ? 25.897 35.074 -15.488 1.00 19.81 ? 236 ASN B N 1 ATOM 1290 C CA . ASN A 1 180 ? 26.367 36.056 -16.471 1.00 21.55 ? 236 ASN B CA 1 ATOM 1291 C C . ASN A 1 180 ? 27.325 35.569 -17.586 1.00 20.09 ? 236 ASN B C 1 ATOM 1292 O O . ASN A 1 180 ? 27.492 36.253 -18.589 1.00 14.34 ? 236 ASN B O 1 ATOM 1293 C CB . ASN A 1 180 ? 26.941 37.301 -15.782 1.00 16.37 ? 236 ASN B CB 1 ATOM 1294 C CG . ASN A 1 180 ? 25.864 38.291 -15.365 1.00 23.32 ? 236 ASN B CG 1 ATOM 1295 O OD1 . ASN A 1 180 ? 25.249 38.140 -14.317 1.00 19.76 ? 236 ASN B OD1 1 ATOM 1296 N ND2 . ASN A 1 180 ? 25.652 39.323 -16.174 1.00 34.79 ? 236 ASN B ND2 1 ATOM 1297 N N . LEU A 1 181 ? 27.924 34.391 -17.458 1.00 20.24 ? 237 LEU B N 1 ATOM 1298 C CA . LEU A 1 181 ? 28.863 33.980 -18.486 1.00 30.65 ? 237 LEU B CA 1 ATOM 1299 C C . LEU A 1 181 ? 28.035 33.255 -19.524 1.00 29.57 ? 237 LEU B C 1 ATOM 1300 O O . LEU A 1 181 ? 27.703 32.089 -19.344 1.00 24.60 ? 237 LEU B O 1 ATOM 1301 C CB . LEU A 1 181 ? 29.872 32.963 -17.934 1.00 37.36 ? 237 LEU B CB 1 ATOM 1302 C CG . LEU A 1 181 ? 30.671 32.994 -16.621 1.00 32.56 ? 237 LEU B CG 1 ATOM 1303 C CD1 . LEU A 1 181 ? 29.857 33.382 -15.424 1.00 39.26 ? 237 LEU B CD1 1 ATOM 1304 C CD2 . LEU A 1 181 ? 31.262 31.606 -16.368 1.00 31.30 ? 237 LEU B CD2 1 ATOM 1305 N N . LYS A 1 182 ? 27.786 33.926 -20.643 1.00 33.08 ? 238 LYS B N 1 ATOM 1306 C CA . LYS A 1 182 ? 26.874 33.440 -21.668 1.00 20.06 ? 238 LYS B CA 1 ATOM 1307 C C . LYS A 1 182 ? 27.602 32.700 -22.784 1.00 14.36 ? 238 LYS B C 1 ATOM 1308 O O . LYS A 1 182 ? 26.981 32.128 -23.656 1.00 3.48 ? 238 LYS B O 1 ATOM 1309 C CB . LYS A 1 182 ? 26.095 34.623 -22.246 1.00 21.15 ? 238 LYS B CB 1 ATOM 1310 C CG . LYS A 1 182 ? 24.625 34.678 -21.849 1.00 26.28 ? 238 LYS B CG 1 ATOM 1311 C CD . LYS A 1 182 ? 24.399 35.365 -20.526 1.00 23.53 ? 238 LYS B CD 1 ATOM 1312 C CE . LYS A 1 182 ? 22.899 35.482 -20.226 1.00 32.14 ? 238 LYS B CE 1 ATOM 1313 N NZ . LYS A 1 182 ? 22.608 35.687 -18.763 1.00 36.76 ? 238 LYS B NZ 1 ATOM 1314 N N . ARG A 1 183 ? 28.923 32.797 -22.789 1.00 15.15 ? 239 ARG B N 1 ATOM 1315 C CA . ARG A 1 183 ? 29.757 32.041 -23.700 1.00 7.77 ? 239 ARG B CA 1 ATOM 1316 C C . ARG A 1 183 ? 30.476 30.837 -23.081 1.00 21.81 ? 239 ARG B C 1 ATOM 1317 O O . ARG A 1 183 ? 31.198 30.144 -23.798 1.00 29.39 ? 239 ARG B O 1 ATOM 1318 C CB . ARG A 1 183 ? 30.779 32.971 -24.347 1.00 11.60 ? 239 ARG B CB 1 ATOM 1319 C CG . ARG A 1 183 ? 30.304 34.405 -24.492 1.00 12.81 ? 239 ARG B CG 1 ATOM 1320 C CD . ARG A 1 183 ? 31.291 35.224 -25.296 1.00 33.03 ? 239 ARG B CD 1 ATOM 1321 N NE . ARG A 1 183 ? 30.937 35.226 -26.716 1.00 55.30 ? 239 ARG B NE 1 ATOM 1322 C CZ . ARG A 1 183 ? 31.051 36.282 -27.524 1.00 62.40 ? 239 ARG B CZ 1 ATOM 1323 N NH1 . ARG A 1 183 ? 31.521 37.435 -27.064 1.00 63.68 ? 239 ARG B NH1 1 ATOM 1324 N NH2 . ARG A 1 183 ? 30.693 36.186 -28.798 1.00 63.67 ? 239 ARG B NH2 1 ATOM 1325 N N . VAL A 1 184 ? 30.319 30.598 -21.771 1.00 29.32 ? 240 VAL B N 1 ATOM 1326 C CA . VAL A 1 184 ? 31.142 29.586 -21.085 1.00 5.10 ? 240 VAL B CA 1 ATOM 1327 C C . VAL A 1 184 ? 30.767 28.176 -21.517 1.00 4.18 ? 240 VAL B C 1 ATOM 1328 O O . VAL A 1 184 ? 29.612 27.778 -21.443 1.00 6.85 ? 240 VAL B O 1 ATOM 1329 C CB . VAL A 1 184 ? 31.150 29.743 -19.498 1.00 5.77 ? 240 VAL B CB 1 ATOM 1330 C CG1 . VAL A 1 184 ? 29.851 29.301 -18.859 1.00 4.35 ? 240 VAL B CG1 1 ATOM 1331 C CG2 . VAL A 1 184 ? 32.298 28.973 -18.870 1.00 5.90 ? 240 VAL B CG2 1 ATOM 1332 N N . GLN A 1 185 ? 31.743 27.463 -22.071 1.00 10.35 ? 241 GLN B N 1 ATOM 1333 C CA . GLN A 1 185 ? 31.559 26.083 -22.513 1.00 10.17 ? 241 GLN B CA 1 ATOM 1334 C C . GLN A 1 185 ? 31.827 24.955 -21.511 1.00 17.94 ? 241 GLN B C 1 ATOM 1335 O O . GLN A 1 185 ? 31.124 23.946 -21.492 1.00 17.74 ? 241 GLN B O 1 ATOM 1336 C CB . GLN A 1 185 ? 32.288 25.863 -23.825 1.00 14.00 ? 241 GLN B CB 1 ATOM 1337 C CG . GLN A 1 185 ? 31.826 26.857 -24.882 1.00 17.48 ? 241 GLN B CG 1 ATOM 1338 C CD . GLN A 1 185 ? 32.291 26.483 -26.260 1.00 17.01 ? 241 GLN B CD 1 ATOM 1339 O OE1 . GLN A 1 185 ? 32.863 25.408 -26.458 1.00 14.73 ? 241 GLN B OE1 1 ATOM 1340 N NE2 . GLN A 1 185 ? 32.047 27.363 -27.227 1.00 18.35 ? 241 GLN B NE2 1 ATOM 1341 N N . THR A 1 186 ? 32.870 25.118 -20.708 1.00 22.16 ? 242 THR B N 1 ATOM 1342 C CA . THR A 1 186 ? 33.292 24.085 -19.779 1.00 4.33 ? 242 THR B CA 1 ATOM 1343 C C . THR A 1 186 ? 33.557 24.675 -18.411 1.00 4.91 ? 242 THR B C 1 ATOM 1344 O O . THR A 1 186 ? 34.361 25.596 -18.243 1.00 8.94 ? 242 THR B O 1 ATOM 1345 C CB . THR A 1 186 ? 34.554 23.355 -20.285 1.00 4.90 ? 242 THR B CB 1 ATOM 1346 O OG1 . THR A 1 186 ? 34.190 22.473 -21.359 1.00 4.18 ? 242 THR B OG1 1 ATOM 1347 C CG2 . THR A 1 186 ? 35.206 22.545 -19.184 1.00 5.16 ? 242 THR B CG2 1 ATOM 1348 N N . ILE A 1 187 ? 32.860 24.148 -17.420 1.00 20.99 ? 243 ILE B N 1 ATOM 1349 C CA . ILE A 1 187 ? 33.190 24.481 -16.059 1.00 18.47 ? 243 ILE B CA 1 ATOM 1350 C C . ILE A 1 187 ? 33.731 23.231 -15.416 1.00 9.97 ? 243 ILE B C 1 ATOM 1351 O O . ILE A 1 187 ? 33.007 22.253 -15.260 1.00 9.09 ? 243 ILE B O 1 ATOM 1352 C CB . ILE A 1 187 ? 31.974 25.008 -15.307 1.00 19.08 ? 243 ILE B CB 1 ATOM 1353 C CG1 . ILE A 1 187 ? 31.625 26.396 -15.843 1.00 18.25 ? 243 ILE B CG1 1 ATOM 1354 C CG2 . ILE A 1 187 ? 32.268 25.067 -13.819 1.00 4.71 ? 243 ILE B CG2 1 ATOM 1355 C CD1 . ILE A 1 187 ? 30.359 26.968 -15.295 1.00 4.07 ? 243 ILE B CD1 1 ATOM 1356 N N . ALA A 1 188 ? 35.017 23.235 -15.091 1.00 5.74 ? 244 ALA B N 1 ATOM 1357 C CA . ALA A 1 188 ? 35.574 22.106 -14.365 1.00 14.33 ? 244 ALA B CA 1 ATOM 1358 C C . ALA A 1 188 ? 35.993 22.524 -12.965 1.00 19.31 ? 244 ALA B C 1 ATOM 1359 O O . ALA A 1 188 ? 37.021 23.164 -12.774 1.00 7.51 ? 244 ALA B O 1 ATOM 1360 C CB . ALA A 1 188 ? 36.769 21.531 -15.121 1.00 11.47 ? 244 ALA B CB 1 ATOM 1361 N N . ILE A 1 189 ? 35.203 22.154 -11.971 1.00 23.83 ? 245 ILE B N 1 ATOM 1362 C CA . ILE A 1 189 ? 35.688 22.233 -10.611 1.00 20.19 ? 245 ILE B CA 1 ATOM 1363 C C . ILE A 1 189 ? 35.370 20.897 -10.000 1.00 22.53 ? 245 ILE B C 1 ATOM 1364 O O . ILE A 1 189 ? 34.255 20.677 -9.535 1.00 30.68 ? 245 ILE B O 1 ATOM 1365 C CB . ILE A 1 189 ? 34.962 23.344 -9.827 1.00 13.96 ? 245 ILE B CB 1 ATOM 1366 C CG1 . ILE A 1 189 ? 34.988 24.649 -10.619 1.00 15.08 ? 245 ILE B CG1 1 ATOM 1367 C CG2 . ILE A 1 189 ? 35.641 23.574 -8.507 1.00 11.09 ? 245 ILE B CG2 1 ATOM 1368 C CD1 . ILE A 1 189 ? 34.414 25.838 -9.889 1.00 9.69 ? 245 ILE B CD1 1 ATOM 1369 N N . TYR A 1 190 ? 36.380 20.043 -9.902 1.00 19.02 ? 246 TYR B N 1 ATOM 1370 C CA . TYR A 1 190 ? 36.153 18.670 -9.496 1.00 12.06 ? 246 TYR B CA 1 ATOM 1371 C C . TYR A 1 190 ? 37.249 18.202 -8.578 1.00 17.94 ? 246 TYR B C 1 ATOM 1372 O O . TYR A 1 190 ? 38.420 18.556 -8.778 1.00 22.03 ? 246 TYR B O 1 ATOM 1373 C CB . TYR A 1 190 ? 35.975 17.718 -10.695 1.00 10.96 ? 246 TYR B CB 1 ATOM 1374 C CG . TYR A 1 190 ? 37.117 17.585 -11.693 1.00 12.88 ? 246 TYR B CG 1 ATOM 1375 C CD1 . TYR A 1 190 ? 38.223 16.800 -11.417 1.00 8.17 ? 246 TYR B CD1 1 ATOM 1376 C CD2 . TYR A 1 190 ? 37.041 18.186 -12.952 1.00 24.39 ? 246 TYR B CD2 1 ATOM 1377 C CE1 . TYR A 1 190 ? 39.248 16.654 -12.348 1.00 13.95 ? 246 TYR B CE1 1 ATOM 1378 C CE2 . TYR A 1 190 ? 38.058 18.046 -13.890 1.00 6.10 ? 246 TYR B CE2 1 ATOM 1379 C CZ . TYR A 1 190 ? 39.157 17.281 -13.579 1.00 13.91 ? 246 TYR B CZ 1 ATOM 1380 O OH . TYR A 1 190 ? 40.175 17.135 -14.491 1.00 16.01 ? 246 TYR B OH 1 ATOM 1381 N N . THR A 1 191 ? 36.856 17.404 -7.579 1.00 16.28 ? 247 THR B N 1 ATOM 1382 C CA . THR A 1 191 ? 37.740 17.043 -6.483 1.00 6.32 ? 247 THR B CA 1 ATOM 1383 C C . THR A 1 191 ? 38.205 18.341 -5.830 1.00 14.07 ? 247 THR B C 1 ATOM 1384 O O . THR A 1 191 ? 39.378 18.689 -5.860 1.00 16.68 ? 247 THR B O 1 ATOM 1385 C CB . THR A 1 191 ? 38.937 16.202 -6.969 1.00 37.43 ? 247 THR B CB 1 ATOM 1386 O OG1 . THR A 1 191 ? 38.471 15.154 -7.836 1.00 6.01 ? 247 THR B OG1 1 ATOM 1387 C CG2 . THR A 1 191 ? 39.682 15.609 -5.799 1.00 7.39 ? 247 THR B CG2 1 ATOM 1388 N N . SER A 1 192 ? 37.245 19.066 -5.268 1.00 20.43 ? 248 SER B N 1 ATOM 1389 C CA . SER A 1 192 ? 37.497 20.303 -4.524 1.00 29.75 ? 248 SER B CA 1 ATOM 1390 C C . SER A 1 192 ? 36.766 20.326 -3.166 1.00 32.28 ? 248 SER B C 1 ATOM 1391 O O . SER A 1 192 ? 36.333 19.282 -2.670 1.00 34.76 ? 248 SER B O 1 ATOM 1392 C CB . SER A 1 192 ? 37.160 21.533 -5.368 1.00 34.15 ? 248 SER B CB 1 ATOM 1393 O OG . SER A 1 192 ? 38.260 21.899 -6.180 1.00 37.92 ? 248 SER B OG 1 ATOM 1394 N N . LEU A 1 193 ? 36.734 21.490 -2.521 1.00 30.78 ? 249 LEU B N 1 ATOM 1395 C CA . LEU A 1 193 ? 35.965 21.678 -1.274 1.00 36.05 ? 249 LEU B CA 1 ATOM 1396 C C . LEU A 1 193 ? 34.589 22.340 -1.413 1.00 29.69 ? 249 LEU B C 1 ATOM 1397 O O . LEU A 1 193 ? 34.033 22.796 -0.417 1.00 36.78 ? 249 LEU B O 1 ATOM 1398 C CB . LEU A 1 193 ? 36.810 22.283 -0.140 1.00 8.96 ? 249 LEU B CB 1 ATOM 1399 C CG . LEU A 1 193 ? 38.091 21.453 0.012 1.00 37.20 ? 249 LEU B CG 1 ATOM 1400 C CD1 . LEU A 1 193 ? 39.159 22.126 0.839 1.00 10.90 ? 249 LEU B CD1 1 ATOM 1401 C CD2 . LEU A 1 193 ? 37.767 20.108 0.580 1.00 8.80 ? 249 LEU B CD2 1 ATOM 1402 N N . LEU A 1 194 ? 34.096 22.473 -2.644 1.00 21.89 ? 250 LEU B N 1 ATOM 1403 C CA . LEU A 1 194 ? 32.788 23.089 -2.901 1.00 18.88 ? 250 LEU B CA 1 ATOM 1404 C C . LEU A 1 194 ? 31.660 22.515 -2.038 1.00 12.52 ? 250 LEU B C 1 ATOM 1405 O O . LEU A 1 194 ? 31.600 21.313 -1.804 1.00 19.59 ? 250 LEU B O 1 ATOM 1406 C CB . LEU A 1 194 ? 32.398 22.914 -4.373 1.00 16.13 ? 250 LEU B CB 1 ATOM 1407 C CG . LEU A 1 194 ? 32.993 23.771 -5.496 1.00 11.00 ? 250 LEU B CG 1 ATOM 1408 C CD1 . LEU A 1 194 ? 32.174 23.611 -6.782 1.00 11.63 ? 250 LEU B CD1 1 ATOM 1409 C CD2 . LEU A 1 194 ? 33.046 25.239 -5.096 1.00 14.28 ? 250 LEU B CD2 1 ATOM 1410 N N . SER A 1 195 ? 30.780 23.389 -1.558 1.00 4.90 ? 251 SER B N 1 ATOM 1411 C CA . SER A 1 195 ? 29.565 22.977 -0.843 1.00 14.83 ? 251 SER B CA 1 ATOM 1412 C C . SER A 1 195 ? 28.378 23.856 -1.208 1.00 16.08 ? 251 SER B C 1 ATOM 1413 O O . SER A 1 195 ? 28.515 24.796 -1.977 1.00 28.48 ? 251 SER B O 1 ATOM 1414 C CB . SER A 1 195 ? 29.762 22.908 0.691 1.00 12.04 ? 251 SER B CB 1 ATOM 1415 O OG . SER A 1 195 ? 30.520 23.993 1.214 1.00 15.67 ? 251 SER B OG 1 ATOM 1416 N N . GLY A 1 196 ? 27.207 23.558 -0.666 1.00 15.63 ? 252 GLY B N 1 ATOM 1417 C CA . GLY A 1 196 ? 26.027 24.324 -1.023 1.00 3.49 ? 252 GLY B CA 1 ATOM 1418 C C . GLY A 1 196 ? 25.393 23.799 -2.286 1.00 23.76 ? 252 GLY B C 1 ATOM 1419 O O . GLY A 1 196 ? 25.918 22.879 -2.925 1.00 31.12 ? 252 GLY B O 1 ATOM 1420 N N . PRO A 1 197 ? 24.242 24.365 -2.656 1.00 13.69 ? 253 PRO B N 1 ATOM 1421 C CA . PRO A 1 197 ? 23.572 23.942 -3.886 1.00 14.39 ? 253 PRO B CA 1 ATOM 1422 C C . PRO A 1 197 ? 24.191 24.563 -5.154 1.00 18.41 ? 253 PRO B C 1 ATOM 1423 O O . PRO A 1 197 ? 24.742 25.672 -5.118 1.00 17.53 ? 253 PRO B O 1 ATOM 1424 C CB . PRO A 1 197 ? 22.152 24.478 -3.684 1.00 10.36 ? 253 PRO B CB 1 ATOM 1425 C CG . PRO A 1 197 ? 22.370 25.765 -2.988 1.00 2.79 ? 253 PRO B CG 1 ATOM 1426 C CD . PRO A 1 197 ? 23.538 25.488 -2.015 1.00 10.05 ? 253 PRO B CD 1 ATOM 1427 N N . ILE A 1 198 ? 24.087 23.844 -6.268 1.00 16.16 ? 254 ILE B N 1 ATOM 1428 C CA . ILE A 1 198 ? 24.391 24.413 -7.567 1.00 11.89 ? 254 ILE B CA 1 ATOM 1429 C C . ILE A 1 198 ? 23.427 25.576 -7.717 1.00 7.92 ? 254 ILE B C 1 ATOM 1430 O O . ILE A 1 198 ? 22.235 25.417 -7.472 1.00 9.92 ? 254 ILE B O 1 ATOM 1431 C CB . ILE A 1 198 ? 24.137 23.384 -8.682 1.00 18.83 ? 254 ILE B CB 1 ATOM 1432 C CG1 . ILE A 1 198 ? 25.028 22.159 -8.492 1.00 11.60 ? 254 ILE B CG1 1 ATOM 1433 C CG2 . ILE A 1 198 ? 24.386 23.987 -10.051 1.00 30.01 ? 254 ILE B CG2 1 ATOM 1434 C CD1 . ILE A 1 198 ? 24.516 20.929 -9.214 1.00 5.24 ? 254 ILE B CD1 1 ATOM 1435 N N . PRO A 1 199 ? 23.934 26.765 -8.074 1.00 2.24 ? 255 PRO B N 1 ATOM 1436 C CA . PRO A 1 199 ? 22.992 27.877 -8.220 1.00 8.75 ? 255 PRO B CA 1 ATOM 1437 C C . PRO A 1 199 ? 22.110 27.700 -9.459 1.00 14.14 ? 255 PRO B C 1 ATOM 1438 O O . PRO A 1 199 ? 22.572 27.285 -10.522 1.00 18.34 ? 255 PRO B O 1 ATOM 1439 C CB . PRO A 1 199 ? 23.902 29.102 -8.353 1.00 3.15 ? 255 PRO B CB 1 ATOM 1440 C CG . PRO A 1 199 ? 25.182 28.573 -8.861 1.00 13.07 ? 255 PRO B CG 1 ATOM 1441 C CD . PRO A 1 199 ? 25.318 27.154 -8.387 1.00 2.65 ? 255 PRO B CD 1 ATOM 1442 N N . ASP A 1 200 ? 20.833 28.014 -9.299 1.00 22.80 ? 256 ASP B N 1 ATOM 1443 C CA . ASP A 1 200 ? 19.851 27.896 -10.364 1.00 19.00 ? 256 ASP B CA 1 ATOM 1444 C C . ASP A 1 200 ? 20.265 28.688 -11.594 1.00 20.63 ? 256 ASP B C 1 ATOM 1445 O O . ASP A 1 200 ? 19.997 28.301 -12.739 1.00 24.18 ? 256 ASP B O 1 ATOM 1446 C CB . ASP A 1 200 ? 18.505 28.408 -9.853 1.00 17.50 ? 256 ASP B CB 1 ATOM 1447 C CG . ASP A 1 200 ? 17.703 27.329 -9.174 1.00 24.99 ? 256 ASP B CG 1 ATOM 1448 O OD1 . ASP A 1 200 ? 17.937 27.079 -7.969 1.00 37.04 ? 256 ASP B OD1 1 ATOM 1449 O OD2 . ASP A 1 200 ? 16.846 26.722 -9.856 1.00 21.22 ? 256 ASP B OD2 1 ATOM 1450 N N . GLU A 1 201 ? 20.955 29.791 -11.336 1.00 16.03 ? 257 GLU B N 1 ATOM 1451 C CA . GLU A 1 201 ? 21.313 30.755 -12.362 1.00 14.26 ? 257 GLU B CA 1 ATOM 1452 C C . GLU A 1 201 ? 22.291 30.168 -13.382 1.00 15.97 ? 257 GLU B C 1 ATOM 1453 O O . GLU A 1 201 ? 22.582 30.808 -14.388 1.00 22.14 ? 257 GLU B O 1 ATOM 1454 C CB . GLU A 1 201 ? 21.872 32.043 -11.727 1.00 9.43 ? 257 GLU B CB 1 ATOM 1455 C CG . GLU A 1 201 ? 20.862 32.823 -10.882 1.00 11.89 ? 257 GLU B CG 1 ATOM 1456 C CD . GLU A 1 201 ? 20.417 32.060 -9.628 1.00 22.38 ? 257 GLU B CD 1 ATOM 1457 O OE1 . GLU A 1 201 ? 21.285 31.446 -8.963 1.00 4.73 ? 257 GLU B OE1 1 ATOM 1458 O OE2 . GLU A 1 201 ? 19.195 32.049 -9.328 1.00 30.67 ? 257 GLU B OE2 1 ATOM 1459 N N . ILE A 1 202 ? 22.792 28.957 -13.124 1.00 8.44 ? 258 ILE B N 1 ATOM 1460 C CA . ILE A 1 202 ? 23.661 28.273 -14.081 1.00 15.97 ? 258 ILE B CA 1 ATOM 1461 C C . ILE A 1 202 ? 22.869 27.884 -15.322 1.00 28.96 ? 258 ILE B C 1 ATOM 1462 O O . ILE A 1 202 ? 23.448 27.552 -16.355 1.00 38.11 ? 258 ILE B O 1 ATOM 1463 C CB . ILE A 1 202 ? 24.350 27.013 -13.492 1.00 6.07 ? 258 ILE B CB 1 ATOM 1464 C CG1 . ILE A 1 202 ? 25.685 26.753 -14.197 1.00 5.22 ? 258 ILE B CG1 1 ATOM 1465 C CG2 . ILE A 1 202 ? 23.459 25.790 -13.614 1.00 4.04 ? 258 ILE B CG2 1 ATOM 1466 C CD1 . ILE A 1 202 ? 26.433 25.541 -13.692 1.00 5.20 ? 258 ILE B CD1 1 ATOM 1467 N N . GLY A 1 203 ? 21.543 27.940 -15.227 1.00 27.02 ? 259 GLY B N 1 ATOM 1468 C CA . GLY A 1 203 ? 20.707 27.693 -16.391 1.00 24.64 ? 259 GLY B CA 1 ATOM 1469 C C . GLY A 1 203 ? 20.782 28.856 -17.361 1.00 20.92 ? 259 GLY B C 1 ATOM 1470 O O . GLY A 1 203 ? 20.276 28.785 -18.482 1.00 20.31 ? 259 GLY B O 1 ATOM 1471 N N . TYR A 1 204 ? 21.421 29.934 -16.917 1.00 23.39 ? 260 TYR B N 1 ATOM 1472 C CA . TYR A 1 204 ? 21.570 31.143 -17.717 1.00 24.52 ? 260 TYR B CA 1 ATOM 1473 C C . TYR A 1 204 ? 22.831 31.133 -18.577 1.00 22.84 ? 260 TYR B C 1 ATOM 1474 O O . TYR A 1 204 ? 23.047 32.070 -19.339 1.00 27.35 ? 260 TYR B O 1 ATOM 1475 C CB . TYR A 1 204 ? 21.595 32.383 -16.815 1.00 28.69 ? 260 TYR B CB 1 ATOM 1476 C CG . TYR A 1 204 ? 20.242 32.849 -16.316 1.00 24.14 ? 260 TYR B CG 1 ATOM 1477 C CD1 . TYR A 1 204 ? 19.189 33.057 -17.196 1.00 17.33 ? 260 TYR B CD1 1 ATOM 1478 C CD2 . TYR A 1 204 ? 20.027 33.096 -14.962 1.00 13.61 ? 260 TYR B CD2 1 ATOM 1479 C CE1 . TYR A 1 204 ? 17.969 33.491 -16.743 1.00 24.41 ? 260 TYR B CE1 1 ATOM 1480 C CE2 . TYR A 1 204 ? 18.800 33.534 -14.502 1.00 16.02 ? 260 TYR B CE2 1 ATOM 1481 C CZ . TYR A 1 204 ? 17.774 33.723 -15.391 1.00 21.35 ? 260 TYR B CZ 1 ATOM 1482 O OH . TYR A 1 204 ? 16.547 34.164 -14.945 1.00 23.02 ? 260 TYR B OH 1 ATOM 1483 N N . CYS A 1 205 ? 23.664 30.096 -18.466 1.00 17.14 ? 261 CYS B N 1 ATOM 1484 C CA . CYS A 1 205 ? 24.797 29.990 -19.381 1.00 23.66 ? 261 CYS B CA 1 ATOM 1485 C C . CYS A 1 205 ? 24.388 29.139 -20.584 1.00 22.75 ? 261 CYS B C 1 ATOM 1486 O O . CYS A 1 205 ? 24.382 27.913 -20.498 1.00 20.47 ? 261 CYS B O 1 ATOM 1487 C CB . CYS A 1 205 ? 25.970 29.291 -18.694 1.00 34.59 ? 261 CYS B CB 1 ATOM 1488 S SG . CYS A 1 205 ? 26.115 29.469 -16.890 1.00 13.79 ? 261 CYS B SG 1 ATOM 1489 N N . THR A 1 206 ? 24.151 29.777 -21.730 1.00 20.34 ? 262 THR B N 1 ATOM 1490 C CA . THR A 1 206 ? 23.480 29.098 -22.846 1.00 14.19 ? 262 THR B CA 1 ATOM 1491 C C . THR A 1 206 ? 24.433 28.161 -23.551 1.00 13.08 ? 262 THR B C 1 ATOM 1492 O O . THR A 1 206 ? 24.042 27.090 -24.022 1.00 12.19 ? 262 THR B O 1 ATOM 1493 C CB . THR A 1 206 ? 22.944 30.075 -23.901 1.00 11.62 ? 262 THR B CB 1 ATOM 1494 O OG1 . THR A 1 206 ? 24.040 30.599 -24.655 1.00 30.58 ? 262 THR B OG1 1 ATOM 1495 C CG2 . THR A 1 206 ? 22.183 31.216 -23.260 1.00 6.89 ? 262 THR B CG2 1 ATOM 1496 N N . GLU A 1 207 ? 25.690 28.585 -23.595 1.00 12.34 ? 263 GLU B N 1 ATOM 1497 C CA . GLU A 1 207 ? 26.752 27.888 -24.291 1.00 11.60 ? 263 GLU B CA 1 ATOM 1498 C C . GLU A 1 207 ? 27.390 26.737 -23.512 1.00 13.33 ? 263 GLU B C 1 ATOM 1499 O O . GLU A 1 207 ? 28.251 26.055 -24.050 1.00 18.97 ? 263 GLU B O 1 ATOM 1500 C CB . GLU A 1 207 ? 27.829 28.900 -24.657 1.00 20.78 ? 263 GLU B CB 1 ATOM 1501 C CG . GLU A 1 207 ? 27.356 29.933 -25.658 1.00 34.54 ? 263 GLU B CG 1 ATOM 1502 C CD . GLU A 1 207 ? 27.203 29.375 -27.050 1.00 47.41 ? 263 GLU B CD 1 ATOM 1503 O OE1 . GLU A 1 207 ? 28.210 28.888 -27.614 1.00 50.46 ? 263 GLU B OE1 1 ATOM 1504 O OE2 . GLU A 1 207 ? 26.072 29.423 -27.578 1.00 53.89 ? 263 GLU B OE2 1 ATOM 1505 N N . LEU A 1 208 ? 26.976 26.520 -22.262 1.00 15.09 ? 264 LEU B N 1 ATOM 1506 C CA . LEU A 1 208 ? 27.594 25.495 -21.406 1.00 13.99 ? 264 LEU B CA 1 ATOM 1507 C C . LEU A 1 208 ? 27.466 24.084 -21.981 1.00 18.80 ? 264 LEU B C 1 ATOM 1508 O O . LEU A 1 208 ? 26.371 23.633 -22.320 1.00 18.91 ? 264 LEU B O 1 ATOM 1509 C CB . LEU A 1 208 ? 27.034 25.544 -19.974 1.00 12.06 ? 264 LEU B CB 1 ATOM 1510 C CG . LEU A 1 208 ? 27.671 24.594 -18.939 1.00 7.50 ? 264 LEU B CG 1 ATOM 1511 C CD1 . LEU A 1 208 ? 29.026 25.083 -18.499 1.00 2.00 ? 264 LEU B CD1 1 ATOM 1512 C CD2 . LEU A 1 208 ? 26.790 24.371 -17.728 1.00 2.00 ? 264 LEU B CD2 1 ATOM 1513 N N . GLN A 1 209 ? 28.604 23.402 -22.079 1.00 21.81 ? 265 GLN B N 1 ATOM 1514 C CA . GLN A 1 209 ? 28.714 22.077 -22.695 1.00 17.42 ? 265 GLN B CA 1 ATOM 1515 C C . GLN A 1 209 ? 28.968 20.993 -21.650 1.00 10.63 ? 265 GLN B C 1 ATOM 1516 O O . GLN A 1 209 ? 28.267 19.985 -21.617 1.00 8.46 ? 265 GLN B O 1 ATOM 1517 C CB . GLN A 1 209 ? 29.761 22.042 -23.831 1.00 14.17 ? 265 GLN B CB 1 ATOM 1518 C CG . GLN A 1 209 ? 29.341 22.833 -25.098 1.00 21.73 ? 265 GLN B CG 1 ATOM 1519 C CD . GLN A 1 209 ? 30.287 22.664 -26.311 1.00 23.84 ? 265 GLN B CD 1 ATOM 1520 O OE1 . GLN A 1 209 ? 31.394 22.131 -26.196 1.00 26.82 ? 265 GLN B OE1 1 ATOM 1521 N NE2 . GLN A 1 209 ? 29.839 23.127 -27.474 1.00 19.78 ? 265 GLN B NE2 1 ATOM 1522 N N . ASN A 1 210 ? 30.033 21.163 -20.871 1.00 14.77 ? 266 ASN B N 1 ATOM 1523 C CA . ASN A 1 210 ? 30.446 20.188 -19.857 1.00 10.97 ? 266 ASN B CA 1 ATOM 1524 C C . ASN A 1 210 ? 30.405 20.745 -18.439 1.00 4.77 ? 266 ASN B C 1 ATOM 1525 O O . ASN A 1 210 ? 31.021 21.770 -18.151 1.00 5.41 ? 266 ASN B O 1 ATOM 1526 C CB . ASN A 1 210 ? 31.878 19.735 -20.153 1.00 11.83 ? 266 ASN B CB 1 ATOM 1527 C CG . ASN A 1 210 ? 32.123 19.508 -21.641 1.00 14.00 ? 266 ASN B CG 1 ATOM 1528 O OD1 . ASN A 1 210 ? 31.565 18.592 -22.239 1.00 7.27 ? 266 ASN B OD1 1 ATOM 1529 N ND2 . ASN A 1 210 ? 32.962 20.345 -22.238 1.00 16.94 ? 266 ASN B ND2 1 ATOM 1530 N N . LEU A 1 211 ? 29.708 20.082 -17.528 1.00 6.98 ? 267 LEU B N 1 ATOM 1531 C CA . LEU A 1 211 ? 29.784 20.529 -16.130 1.00 9.77 ? 267 LEU B CA 1 ATOM 1532 C C . LEU A 1 211 ? 30.450 19.491 -15.223 1.00 10.30 ? 267 LEU B C 1 ATOM 1533 O O . LEU A 1 211 ? 29.874 18.427 -14.976 1.00 4.13 ? 267 LEU B O 1 ATOM 1534 C CB . LEU A 1 211 ? 28.397 20.892 -15.608 1.00 4.10 ? 267 LEU B CB 1 ATOM 1535 C CG . LEU A 1 211 ? 28.311 21.545 -14.233 1.00 4.45 ? 267 LEU B CG 1 ATOM 1536 C CD1 . LEU A 1 211 ? 29.208 22.769 -14.126 1.00 4.63 ? 267 LEU B CD1 1 ATOM 1537 C CD2 . LEU A 1 211 ? 26.867 21.924 -13.972 1.00 4.66 ? 267 LEU B CD2 1 ATOM 1538 N N . TYR A 1 212 ? 31.663 19.774 -14.740 1.00 15.04 ? 268 TYR B N 1 ATOM 1539 C CA . TYR A 1 212 ? 32.324 18.801 -13.870 1.00 16.88 ? 268 TYR B CA 1 ATOM 1540 C C . TYR A 1 212 ? 32.461 19.362 -12.464 1.00 12.68 ? 268 TYR B C 1 ATOM 1541 O O . TYR A 1 212 ? 33.367 20.148 -12.190 1.00 15.50 ? 268 TYR B O 1 ATOM 1542 C CB . TYR A 1 212 ? 33.724 18.484 -14.411 1.00 19.13 ? 268 TYR B CB 1 ATOM 1543 C CG . TYR A 1 212 ? 33.773 18.134 -15.883 1.00 20.06 ? 268 TYR B CG 1 ATOM 1544 C CD1 . TYR A 1 212 ? 32.710 17.494 -16.508 1.00 17.12 ? 268 TYR B CD1 1 ATOM 1545 C CD2 . TYR A 1 212 ? 34.887 18.445 -16.649 1.00 22.13 ? 268 TYR B CD2 1 ATOM 1546 C CE1 . TYR A 1 212 ? 32.755 17.177 -17.842 1.00 12.82 ? 268 TYR B CE1 1 ATOM 1547 C CE2 . TYR A 1 212 ? 34.940 18.129 -17.985 1.00 19.22 ? 268 TYR B CE2 1 ATOM 1548 C CZ . TYR A 1 212 ? 33.871 17.494 -18.576 1.00 16.64 ? 268 TYR B CZ 1 ATOM 1549 O OH . TYR A 1 212 ? 33.916 17.182 -19.915 1.00 14.16 ? 268 TYR B OH 1 ATOM 1550 N N . LEU A 1 213 ? 31.531 18.963 -11.600 1.00 9.18 ? 269 LEU B N 1 ATOM 1551 C CA . LEU A 1 213 ? 31.513 19.280 -10.171 1.00 9.65 ? 269 LEU B CA 1 ATOM 1552 C C . LEU A 1 213 ? 31.765 18.078 -9.251 1.00 17.85 ? 269 LEU B C 1 ATOM 1553 O O . LEU A 1 213 ? 31.586 18.162 -8.042 1.00 17.39 ? 269 LEU B O 1 ATOM 1554 C CB . LEU A 1 213 ? 30.260 20.080 -9.801 1.00 6.23 ? 269 LEU B CB 1 ATOM 1555 C CG . LEU A 1 213 ? 30.239 21.390 -10.607 1.00 12.56 ? 269 LEU B CG 1 ATOM 1556 C CD1 . LEU A 1 213 ? 28.998 22.233 -10.369 1.00 2.00 ? 269 LEU B CD1 1 ATOM 1557 C CD2 . LEU A 1 213 ? 31.501 22.193 -10.351 1.00 3.38 ? 269 LEU B CD2 1 ATOM 1558 N N . TYR A 1 214 ? 32.098 16.938 -9.843 1.00 27.91 ? 270 TYR B N 1 ATOM 1559 C CA . TYR A 1 214 ? 32.198 15.684 -9.098 1.00 22.87 ? 270 TYR B CA 1 ATOM 1560 C C . TYR A 1 214 ? 33.219 15.724 -7.975 1.00 10.74 ? 270 TYR B C 1 ATOM 1561 O O . TYR A 1 214 ? 34.185 16.487 -8.050 1.00 13.04 ? 270 TYR B O 1 ATOM 1562 C CB . TYR A 1 214 ? 32.454 14.499 -10.044 1.00 22.03 ? 270 TYR B CB 1 ATOM 1563 C CG . TYR A 1 214 ? 33.813 14.416 -10.719 1.00 11.87 ? 270 TYR B CG 1 ATOM 1564 C CD1 . TYR A 1 214 ? 34.877 13.803 -10.089 1.00 11.56 ? 270 TYR B CD1 1 ATOM 1565 C CD2 . TYR A 1 214 ? 34.004 14.882 -12.012 1.00 7.41 ? 270 TYR B CD2 1 ATOM 1566 C CE1 . TYR A 1 214 ? 36.097 13.684 -10.713 1.00 11.80 ? 270 TYR B CE1 1 ATOM 1567 C CE2 . TYR A 1 214 ? 35.218 14.778 -12.632 1.00 8.48 ? 270 TYR B CE2 1 ATOM 1568 C CZ . TYR A 1 214 ? 36.263 14.182 -11.982 1.00 9.47 ? 270 TYR B CZ 1 ATOM 1569 O OH . TYR A 1 214 ? 37.484 14.068 -12.595 1.00 19.35 ? 270 TYR B OH 1 ATOM 1570 N N . GLN A 1 215 ? 32.985 14.902 -6.942 1.00 6.11 ? 271 GLN B N 1 ATOM 1571 C CA . GLN A 1 215 ? 33.834 14.819 -5.728 1.00 8.98 ? 271 GLN B CA 1 ATOM 1572 C C . GLN A 1 215 ? 33.973 16.110 -4.939 1.00 3.39 ? 271 GLN B C 1 ATOM 1573 O O . GLN A 1 215 ? 35.052 16.625 -4.740 1.00 13.81 ? 271 GLN B O 1 ATOM 1574 C CB . GLN A 1 215 ? 35.197 14.176 -6.006 1.00 3.42 ? 271 GLN B CB 1 ATOM 1575 C CG . GLN A 1 215 ? 35.082 12.679 -6.112 1.00 2.89 ? 271 GLN B CG 1 ATOM 1576 C CD . GLN A 1 215 ? 36.403 11.978 -6.272 1.00 4.44 ? 271 GLN B CD 1 ATOM 1577 O OE1 . GLN A 1 215 ? 37.314 12.491 -6.913 1.00 4.31 ? 271 GLN B OE1 1 ATOM 1578 N NE2 . GLN A 1 215 ? 36.518 10.788 -5.683 1.00 6.16 ? 271 GLN B NE2 1 ATOM 1579 N N . ASN A 1 216 ? 32.835 16.648 -4.548 1.00 10.39 ? 272 ASN B N 1 ATOM 1580 C CA . ASN A 1 216 ? 32.756 17.730 -3.590 1.00 10.29 ? 272 ASN B CA 1 ATOM 1581 C C . ASN A 1 216 ? 31.700 17.301 -2.586 1.00 15.57 ? 272 ASN B C 1 ATOM 1582 O O . ASN A 1 216 ? 31.318 16.130 -2.563 1.00 19.45 ? 272 ASN B O 1 ATOM 1583 C CB . ASN A 1 216 ? 32.358 19.027 -4.277 1.00 14.70 ? 272 ASN B CB 1 ATOM 1584 C CG . ASN A 1 216 ? 33.427 19.533 -5.212 1.00 23.54 ? 272 ASN B CG 1 ATOM 1585 O OD1 . ASN A 1 216 ? 34.311 20.278 -4.805 1.00 30.37 ? 272 ASN B OD1 1 ATOM 1586 N ND2 . ASN A 1 216 ? 33.347 19.141 -6.479 1.00 25.12 ? 272 ASN B ND2 1 ATOM 1587 N N . SER A 1 217 ? 31.272 18.202 -1.711 1.00 12.11 ? 273 SER B N 1 ATOM 1588 C CA . SER A 1 217 ? 30.043 17.937 -0.989 1.00 8.31 ? 273 SER B CA 1 ATOM 1589 C C . SER A 1 217 ? 29.072 18.996 -1.438 1.00 14.03 ? 273 SER B C 1 ATOM 1590 O O . SER A 1 217 ? 29.060 20.084 -0.900 1.00 28.79 ? 273 SER B O 1 ATOM 1591 C CB . SER A 1 217 ? 30.280 18.080 0.515 1.00 10.50 ? 273 SER B CB 1 ATOM 1592 O OG . SER A 1 217 ? 31.645 17.860 0.849 1.00 6.28 ? 273 SER B OG 1 ATOM 1593 N N . ILE A 1 218 ? 28.185 18.652 -2.353 1.00 11.86 ? 274 ILE B N 1 ATOM 1594 C CA . ILE A 1 218 ? 27.308 19.657 -2.926 1.00 9.54 ? 274 ILE B CA 1 ATOM 1595 C C . ILE A 1 218 ? 25.932 19.254 -2.483 1.00 7.12 ? 274 ILE B C 1 ATOM 1596 O O . ILE A 1 218 ? 25.577 18.085 -2.542 1.00 12.35 ? 274 ILE B O 1 ATOM 1597 C CB . ILE A 1 218 ? 27.435 19.747 -4.478 1.00 12.65 ? 274 ILE B CB 1 ATOM 1598 C CG1 . ILE A 1 218 ? 28.756 20.411 -4.855 1.00 4.51 ? 274 ILE B CG1 1 ATOM 1599 C CG2 . ILE A 1 218 ? 26.288 20.557 -5.094 1.00 2.00 ? 274 ILE B CG2 1 ATOM 1600 C CD1 . ILE A 1 218 ? 28.888 20.732 -6.342 1.00 5.13 ? 274 ILE B CD1 1 ATOM 1601 N N . SER A 1 219 ? 25.171 20.219 -2.002 1.00 2.00 ? 275 SER B N 1 ATOM 1602 C CA . SER A 1 219 ? 23.947 19.912 -1.289 1.00 10.24 ? 275 SER B CA 1 ATOM 1603 C C . SER A 1 219 ? 22.792 20.415 -2.113 1.00 6.84 ? 275 SER B C 1 ATOM 1604 O O . SER A 1 219 ? 22.984 20.872 -3.231 1.00 10.62 ? 275 SER B O 1 ATOM 1605 C CB . SER A 1 219 ? 23.946 20.576 0.088 1.00 2.30 ? 275 SER B CB 1 ATOM 1606 O OG . SER A 1 219 ? 23.581 21.940 -0.019 1.00 19.18 ? 275 SER B OG 1 ATOM 1607 N N . GLY A 1 220 ? 21.593 20.344 -1.555 1.00 3.47 ? 276 GLY B N 1 ATOM 1608 C CA . GLY A 1 220 ? 20.422 20.729 -2.302 1.00 2.00 ? 276 GLY B CA 1 ATOM 1609 C C . GLY A 1 220 ? 20.229 19.714 -3.405 1.00 14.65 ? 276 GLY B C 1 ATOM 1610 O O . GLY A 1 220 ? 20.759 18.606 -3.327 1.00 10.64 ? 276 GLY B O 1 ATOM 1611 N N . SER A 1 221 ? 19.489 20.102 -4.441 1.00 18.77 ? 277 SER B N 1 ATOM 1612 C CA . SER A 1 221 ? 19.130 19.206 -5.533 1.00 15.07 ? 277 SER B CA 1 ATOM 1613 C C . SER A 1 221 ? 19.598 19.766 -6.875 1.00 17.14 ? 277 SER B C 1 ATOM 1614 O O . SER A 1 221 ? 19.929 20.949 -6.973 1.00 19.44 ? 277 SER B O 1 ATOM 1615 C CB . SER A 1 221 ? 17.620 19.053 -5.571 1.00 6.89 ? 277 SER B CB 1 ATOM 1616 O OG . SER A 1 221 ? 17.035 20.284 -5.953 1.00 5.26 ? 277 SER B OG 1 ATOM 1617 N N . ILE A 1 222 ? 19.624 18.915 -7.903 1.00 9.73 ? 278 ILE B N 1 ATOM 1618 C CA . ILE A 1 222 ? 20.020 19.340 -9.246 1.00 9.56 ? 278 ILE B CA 1 ATOM 1619 C C . ILE A 1 222 ? 18.992 20.310 -9.818 1.00 14.93 ? 278 ILE B C 1 ATOM 1620 O O . ILE A 1 222 ? 17.842 19.936 -10.040 1.00 15.31 ? 278 ILE B O 1 ATOM 1621 C CB . ILE A 1 222 ? 20.134 18.132 -10.212 1.00 5.82 ? 278 ILE B CB 1 ATOM 1622 C CG1 . ILE A 1 222 ? 21.262 17.191 -9.783 1.00 2.00 ? 278 ILE B CG1 1 ATOM 1623 C CG2 . ILE A 1 222 ? 20.349 18.610 -11.640 1.00 3.76 ? 278 ILE B CG2 1 ATOM 1624 C CD1 . ILE A 1 222 ? 20.988 15.722 -10.102 1.00 2.00 ? 278 ILE B CD1 1 ATOM 1625 N N . PRO A 1 223 ? 19.403 21.554 -10.080 1.00 2.00 ? 279 PRO B N 1 ATOM 1626 C CA . PRO A 1 223 ? 18.433 22.542 -10.558 1.00 15.95 ? 279 PRO B CA 1 ATOM 1627 C C . PRO A 1 223 ? 17.758 22.145 -11.868 1.00 24.04 ? 279 PRO B C 1 ATOM 1628 O O . PRO A 1 223 ? 18.412 21.680 -12.800 1.00 36.30 ? 279 PRO B O 1 ATOM 1629 C CB . PRO A 1 223 ? 19.264 23.825 -10.712 1.00 2.00 ? 279 PRO B CB 1 ATOM 1630 C CG . PRO A 1 223 ? 20.682 23.425 -10.588 1.00 2.00 ? 279 PRO B CG 1 ATOM 1631 C CD . PRO A 1 223 ? 20.752 22.113 -9.904 1.00 11.89 ? 279 PRO B CD 1 ATOM 1632 N N . THR A 1 224 ? 16.442 22.308 -11.911 1.00 23.47 ? 280 THR B N 1 ATOM 1633 C CA . THR A 1 224 ? 15.632 22.037 -13.102 1.00 10.99 ? 280 THR B CA 1 ATOM 1634 C C . THR A 1 224 ? 16.119 22.822 -14.328 1.00 10.94 ? 280 THR B C 1 ATOM 1635 O O . THR A 1 224 ? 16.067 22.340 -15.453 1.00 21.05 ? 280 THR B O 1 ATOM 1636 C CB . THR A 1 224 ? 14.154 22.381 -12.805 1.00 5.23 ? 280 THR B CB 1 ATOM 1637 O OG1 . THR A 1 224 ? 13.620 21.413 -11.888 1.00 9.48 ? 280 THR B OG1 1 ATOM 1638 C CG2 . THR A 1 224 ? 13.328 22.364 -14.051 1.00 2.00 ? 280 THR B CG2 1 ATOM 1639 N N . THR A 1 225 ? 16.628 24.026 -14.091 1.00 8.31 ? 281 THR B N 1 ATOM 1640 C CA . THR A 1 225 ? 17.042 24.934 -15.147 1.00 2.00 ? 281 THR B CA 1 ATOM 1641 C C . THR A 1 225 ? 18.180 24.407 -16.010 1.00 2.98 ? 281 THR B C 1 ATOM 1642 O O . THR A 1 225 ? 18.436 24.940 -17.093 1.00 12.71 ? 281 THR B O 1 ATOM 1643 C CB . THR A 1 225 ? 17.475 26.259 -14.564 1.00 2.00 ? 281 THR B CB 1 ATOM 1644 O OG1 . THR A 1 225 ? 18.570 26.033 -13.666 1.00 2.33 ? 281 THR B OG1 1 ATOM 1645 C CG2 . THR A 1 225 ? 16.313 26.898 -13.809 1.00 8.23 ? 281 THR B CG2 1 ATOM 1646 N N . ILE A 1 226 ? 18.856 23.358 -15.554 1.00 2.14 ? 282 ILE B N 1 ATOM 1647 C CA . ILE A 1 226 ? 19.882 22.720 -16.381 1.00 10.02 ? 282 ILE B CA 1 ATOM 1648 C C . ILE A 1 226 ? 19.268 22.114 -17.659 1.00 15.98 ? 282 ILE B C 1 ATOM 1649 O O . ILE A 1 226 ? 19.947 21.951 -18.670 1.00 23.77 ? 282 ILE B O 1 ATOM 1650 C CB . ILE A 1 226 ? 20.725 21.704 -15.566 1.00 20.64 ? 282 ILE B CB 1 ATOM 1651 C CG1 . ILE A 1 226 ? 21.411 22.435 -14.415 1.00 12.02 ? 282 ILE B CG1 1 ATOM 1652 C CG2 . ILE A 1 226 ? 21.775 21.020 -16.433 1.00 25.37 ? 282 ILE B CG2 1 ATOM 1653 C CD1 . ILE A 1 226 ? 22.508 21.664 -13.770 1.00 4.89 ? 282 ILE B CD1 1 ATOM 1654 N N . GLY A 1 227 ? 17.968 21.844 -17.629 1.00 15.96 ? 283 GLY B N 1 ATOM 1655 C CA . GLY A 1 227 ? 17.265 21.384 -18.814 1.00 13.94 ? 283 GLY B CA 1 ATOM 1656 C C . GLY A 1 227 ? 17.180 22.407 -19.943 1.00 21.91 ? 283 GLY B C 1 ATOM 1657 O O . GLY A 1 227 ? 16.910 22.065 -21.099 1.00 28.01 ? 283 GLY B O 1 ATOM 1658 N N . GLY A 1 228 ? 17.399 23.678 -19.632 1.00 20.95 ? 284 GLY B N 1 ATOM 1659 C CA . GLY A 1 228 ? 17.255 24.677 -20.673 1.00 2.00 ? 284 GLY B CA 1 ATOM 1660 C C . GLY A 1 228 ? 18.569 24.891 -21.379 1.00 4.56 ? 284 GLY B C 1 ATOM 1661 O O . GLY A 1 228 ? 18.689 25.753 -22.262 1.00 2.00 ? 284 GLY B O 1 ATOM 1662 N N . LEU A 1 229 ? 19.554 24.077 -21.012 1.00 6.68 ? 285 LEU B N 1 ATOM 1663 C CA . LEU A 1 229 ? 20.864 24.201 -21.615 1.00 13.20 ? 285 LEU B CA 1 ATOM 1664 C C . LEU A 1 229 ? 20.855 23.325 -22.857 1.00 17.34 ? 285 LEU B C 1 ATOM 1665 O O . LEU A 1 229 ? 21.012 22.107 -22.791 1.00 17.83 ? 285 LEU B O 1 ATOM 1666 C CB . LEU A 1 229 ? 21.930 23.719 -20.631 1.00 5.58 ? 285 LEU B CB 1 ATOM 1667 C CG . LEU A 1 229 ? 22.045 24.636 -19.418 1.00 7.27 ? 285 LEU B CG 1 ATOM 1668 C CD1 . LEU A 1 229 ? 23.255 24.293 -18.564 1.00 2.00 ? 285 LEU B CD1 1 ATOM 1669 C CD2 . LEU A 1 229 ? 22.088 26.084 -19.858 1.00 2.00 ? 285 LEU B CD2 1 ATOM 1670 N N . LYS A 1 230 ? 20.750 23.979 -24.004 1.00 21.29 ? 286 LYS B N 1 ATOM 1671 C CA . LYS A 1 230 ? 20.421 23.285 -25.240 1.00 17.73 ? 286 LYS B CA 1 ATOM 1672 C C . LYS A 1 230 ? 21.659 22.597 -25.799 1.00 13.04 ? 286 LYS B C 1 ATOM 1673 O O . LYS A 1 230 ? 21.558 21.576 -26.464 1.00 16.98 ? 286 LYS B O 1 ATOM 1674 C CB . LYS A 1 230 ? 19.812 24.251 -26.254 1.00 22.34 ? 286 LYS B CB 1 ATOM 1675 C CG . LYS A 1 230 ? 18.898 23.580 -27.264 1.00 33.00 ? 286 LYS B CG 1 ATOM 1676 C CD . LYS A 1 230 ? 19.223 23.971 -28.744 1.00 39.06 ? 286 LYS B CD 1 ATOM 1677 C CE . LYS A 1 230 ? 20.419 23.198 -29.339 1.00 26.12 ? 286 LYS B CE 1 ATOM 1678 N NZ . LYS A 1 230 ? 20.178 21.733 -29.422 1.00 14.73 ? 286 LYS B NZ 1 ATOM 1679 N N . LYS A 1 231 ? 22.828 23.143 -25.477 1.00 13.62 ? 287 LYS B N 1 ATOM 1680 C CA . LYS A 1 231 ? 24.108 22.623 -25.959 1.00 16.03 ? 287 LYS B CA 1 ATOM 1681 C C . LYS A 1 231 ? 24.788 21.653 -24.976 1.00 16.78 ? 287 LYS B C 1 ATOM 1682 O O . LYS A 1 231 ? 25.924 21.242 -25.209 1.00 18.82 ? 287 LYS B O 1 ATOM 1683 C CB . LYS A 1 231 ? 25.073 23.782 -26.285 1.00 15.68 ? 287 LYS B CB 1 ATOM 1684 C CG . LYS A 1 231 ? 24.556 24.831 -27.265 1.00 10.26 ? 287 LYS B CG 1 ATOM 1685 C CD . LYS A 1 231 ? 24.575 24.319 -28.694 1.00 29.86 ? 287 LYS B CD 1 ATOM 1686 C CE . LYS A 1 231 ? 24.468 25.464 -29.703 1.00 45.93 ? 287 LYS B CE 1 ATOM 1687 N NZ . LYS A 1 231 ? 25.702 26.310 -29.792 1.00 48.51 ? 287 LYS B NZ 1 ATOM 1688 N N . LEU A 1 232 ? 24.115 21.309 -23.879 1.00 16.86 ? 288 LEU B N 1 ATOM 1689 C CA . LEU A 1 232 ? 24.719 20.470 -22.825 1.00 8.95 ? 288 LEU B CA 1 ATOM 1690 C C . LEU A 1 232 ? 25.043 19.042 -23.282 1.00 4.56 ? 288 LEU B C 1 ATOM 1691 O O . LEU A 1 232 ? 24.249 18.386 -23.960 1.00 11.33 ? 288 LEU B O 1 ATOM 1692 C CB . LEU A 1 232 ? 23.837 20.441 -21.559 1.00 16.31 ? 288 LEU B CB 1 ATOM 1693 C CG . LEU A 1 232 ? 24.403 19.788 -20.281 1.00 26.22 ? 288 LEU B CG 1 ATOM 1694 C CD1 . LEU A 1 232 ? 25.314 20.738 -19.494 1.00 2.00 ? 288 LEU B CD1 1 ATOM 1695 C CD2 . LEU A 1 232 ? 23.302 19.223 -19.381 1.00 2.00 ? 288 LEU B CD2 1 ATOM 1696 N N . GLN A 1 233 ? 26.207 18.561 -22.864 1.00 2.00 ? 289 GLN B N 1 ATOM 1697 C CA . GLN A 1 233 ? 26.774 17.316 -23.371 1.00 9.83 ? 289 GLN B CA 1 ATOM 1698 C C . GLN A 1 233 ? 27.172 16.347 -22.268 1.00 13.69 ? 289 GLN B C 1 ATOM 1699 O O . GLN A 1 233 ? 26.775 15.179 -22.281 1.00 15.30 ? 289 GLN B O 1 ATOM 1700 C CB . GLN A 1 233 ? 27.937 17.592 -24.332 1.00 17.32 ? 289 GLN B CB 1 ATOM 1701 C CG . GLN A 1 233 ? 27.463 18.144 -25.675 1.00 19.63 ? 289 GLN B CG 1 ATOM 1702 C CD . GLN A 1 233 ? 28.593 18.577 -26.583 1.00 16.26 ? 289 GLN B CD 1 ATOM 1703 O OE1 . GLN A 1 233 ? 29.664 17.970 -26.598 1.00 8.81 ? 289 GLN B OE1 1 ATOM 1704 N NE2 . GLN A 1 233 ? 28.360 19.642 -27.345 1.00 21.02 ? 289 GLN B NE2 1 ATOM 1705 N N . SER A 1 234 ? 28.044 16.804 -21.375 1.00 11.08 ? 290 SER B N 1 ATOM 1706 C CA . SER A 1 234 ? 28.474 15.979 -20.245 1.00 7.65 ? 290 SER B CA 1 ATOM 1707 C C . SER A 1 234 ? 28.084 16.547 -18.862 1.00 10.69 ? 290 SER B C 1 ATOM 1708 O O . SER A 1 234 ? 28.326 17.718 -18.535 1.00 4.65 ? 290 SER B O 1 ATOM 1709 C CB . SER A 1 234 ? 29.973 15.714 -20.327 1.00 3.95 ? 290 SER B CB 1 ATOM 1710 O OG . SER A 1 234 ? 30.696 16.924 -20.319 1.00 19.76 ? 290 SER B OG 1 ATOM 1711 N N . LEU A 1 235 ? 27.454 15.717 -18.053 1.00 2.00 ? 291 LEU B N 1 ATOM 1712 C CA . LEU A 1 235 ? 27.166 16.129 -16.684 1.00 12.95 ? 291 LEU B CA 1 ATOM 1713 C C . LEU A 1 235 ? 27.812 15.163 -15.665 1.00 8.51 ? 291 LEU B C 1 ATOM 1714 O O . LEU A 1 235 ? 27.329 14.035 -15.497 1.00 2.48 ? 291 LEU B O 1 ATOM 1715 C CB . LEU A 1 235 ? 25.649 16.160 -16.506 1.00 2.00 ? 291 LEU B CB 1 ATOM 1716 C CG . LEU A 1 235 ? 24.970 17.184 -15.615 1.00 18.32 ? 291 LEU B CG 1 ATOM 1717 C CD1 . LEU A 1 235 ? 25.761 18.446 -15.541 1.00 26.57 ? 291 LEU B CD1 1 ATOM 1718 C CD2 . LEU A 1 235 ? 23.645 17.485 -16.223 1.00 20.25 ? 291 LEU B CD2 1 ATOM 1719 N N . LEU A 1 236 ? 28.876 15.593 -14.977 1.00 2.00 ? 292 LEU B N 1 ATOM 1720 C CA . LEU A 1 236 ? 29.478 14.736 -13.951 1.00 10.96 ? 292 LEU B CA 1 ATOM 1721 C C . LEU A 1 236 ? 29.288 15.339 -12.549 1.00 14.10 ? 292 LEU B C 1 ATOM 1722 O O . LEU A 1 236 ? 29.976 16.282 -12.151 1.00 9.66 ? 292 LEU B O 1 ATOM 1723 C CB . LEU A 1 236 ? 30.973 14.533 -14.223 1.00 2.96 ? 292 LEU B CB 1 ATOM 1724 C CG . LEU A 1 236 ? 31.458 13.842 -15.494 1.00 8.30 ? 292 LEU B CG 1 ATOM 1725 C CD1 . LEU A 1 236 ? 32.954 14.073 -15.667 1.00 9.45 ? 292 LEU B CD1 1 ATOM 1726 C CD2 . LEU A 1 236 ? 31.159 12.348 -15.499 1.00 10.61 ? 292 LEU B CD2 1 ATOM 1727 N N . LEU A 1 237 ? 28.319 14.797 -11.822 1.00 13.12 ? 293 LEU B N 1 ATOM 1728 C CA . LEU A 1 237 ? 27.996 15.239 -10.467 1.00 11.96 ? 293 LEU B CA 1 ATOM 1729 C C . LEU A 1 237 ? 28.376 14.260 -9.357 1.00 15.65 ? 293 LEU B C 1 ATOM 1730 O O . LEU A 1 237 ? 27.934 14.404 -8.221 1.00 18.35 ? 293 LEU B O 1 ATOM 1731 C CB . LEU A 1 237 ? 26.552 15.735 -10.379 1.00 9.67 ? 293 LEU B CB 1 ATOM 1732 C CG . LEU A 1 237 ? 26.362 16.822 -11.455 1.00 16.29 ? 293 LEU B CG 1 ATOM 1733 C CD1 . LEU A 1 237 ? 24.928 17.320 -11.616 1.00 2.00 ? 293 LEU B CD1 1 ATOM 1734 C CD2 . LEU A 1 237 ? 27.325 17.975 -11.215 1.00 2.00 ? 293 LEU B CD2 1 ATOM 1735 N N . TRP A 1 238 ? 29.108 13.211 -9.706 1.00 14.96 ? 294 TRP B N 1 ATOM 1736 C CA . TRP A 1 238 ? 29.245 12.085 -8.789 1.00 13.50 ? 294 TRP B CA 1 ATOM 1737 C C . TRP A 1 238 ? 30.013 12.366 -7.485 1.00 12.27 ? 294 TRP B C 1 ATOM 1738 O O . TRP A 1 238 ? 30.924 13.206 -7.457 1.00 11.25 ? 294 TRP B O 1 ATOM 1739 C CB . TRP A 1 238 ? 29.765 10.837 -9.518 1.00 10.00 ? 294 TRP B CB 1 ATOM 1740 C CG . TRP A 1 238 ? 31.106 10.970 -10.167 1.00 9.47 ? 294 TRP B CG 1 ATOM 1741 C CD1 . TRP A 1 238 ? 31.369 11.458 -11.411 1.00 5.54 ? 294 TRP B CD1 1 ATOM 1742 C CD2 . TRP A 1 238 ? 32.371 10.572 -9.612 1.00 11.26 ? 294 TRP B CD2 1 ATOM 1743 N NE1 . TRP A 1 238 ? 32.721 11.410 -11.663 1.00 2.26 ? 294 TRP B NE1 1 ATOM 1744 C CE2 . TRP A 1 238 ? 33.357 10.866 -10.583 1.00 9.11 ? 294 TRP B CE2 1 ATOM 1745 C CE3 . TRP A 1 238 ? 32.763 10.017 -8.388 1.00 12.27 ? 294 TRP B CE3 1 ATOM 1746 C CZ2 . TRP A 1 238 ? 34.716 10.615 -10.362 1.00 2.86 ? 294 TRP B CZ2 1 ATOM 1747 C CZ3 . TRP A 1 238 ? 34.102 9.763 -8.174 1.00 10.08 ? 294 TRP B CZ3 1 ATOM 1748 C CH2 . TRP A 1 238 ? 35.069 10.068 -9.157 1.00 12.84 ? 294 TRP B CH2 1 ATOM 1749 N N . GLN A 1 239 ? 29.636 11.640 -6.428 1.00 2.00 ? 295 GLN B N 1 ATOM 1750 C CA . GLN A 1 239 ? 30.152 11.847 -5.083 1.00 2.00 ? 295 GLN B CA 1 ATOM 1751 C C . GLN A 1 239 ? 29.933 13.257 -4.595 1.00 5.96 ? 295 GLN B C 1 ATOM 1752 O O . GLN A 1 239 ? 30.866 14.050 -4.507 1.00 6.83 ? 295 GLN B O 1 ATOM 1753 C CB . GLN A 1 239 ? 31.620 11.468 -4.927 1.00 2.13 ? 295 GLN B CB 1 ATOM 1754 C CG . GLN A 1 239 ? 31.860 9.986 -4.707 1.00 2.26 ? 295 GLN B CG 1 ATOM 1755 C CD . GLN A 1 239 ? 33.315 9.674 -4.430 1.00 3.43 ? 295 GLN B CD 1 ATOM 1756 O OE1 . GLN A 1 239 ? 34.089 10.540 -4.007 1.00 2.80 ? 295 GLN B OE1 1 ATOM 1757 N NE2 . GLN A 1 239 ? 33.699 8.433 -4.675 1.00 2.77 ? 295 GLN B NE2 1 ATOM 1758 N N . ASN A 1 240 ? 28.681 13.564 -4.299 1.00 4.40 ? 296 ASN B N 1 ATOM 1759 C CA . ASN A 1 240 ? 28.319 14.787 -3.620 1.00 7.49 ? 296 ASN B CA 1 ATOM 1760 C C . ASN A 1 240 ? 27.132 14.458 -2.734 1.00 8.58 ? 296 ASN B C 1 ATOM 1761 O O . ASN A 1 240 ? 26.811 13.289 -2.550 1.00 9.36 ? 296 ASN B O 1 ATOM 1762 C CB . ASN A 1 240 ? 27.967 15.871 -4.628 1.00 14.38 ? 296 ASN B CB 1 ATOM 1763 C CG . ASN A 1 240 ? 29.187 16.469 -5.284 1.00 16.65 ? 296 ASN B CG 1 ATOM 1764 O OD1 . ASN A 1 240 ? 29.703 17.481 -4.834 1.00 22.04 ? 296 ASN B OD1 1 ATOM 1765 N ND2 . ASN A 1 240 ? 29.651 15.850 -6.357 1.00 24.47 ? 296 ASN B ND2 1 ATOM 1766 N N . ASN A 1 241 ? 26.500 15.475 -2.161 1.00 11.44 ? 297 ASN B N 1 ATOM 1767 C CA . ASN A 1 241 ? 25.368 15.256 -1.256 1.00 14.37 ? 297 ASN B CA 1 ATOM 1768 C C . ASN A 1 241 ? 24.023 15.389 -1.936 1.00 16.84 ? 297 ASN B C 1 ATOM 1769 O O . ASN A 1 241 ? 23.003 15.402 -1.260 1.00 25.65 ? 297 ASN B O 1 ATOM 1770 C CB . ASN A 1 241 ? 25.414 16.172 -0.018 1.00 16.22 ? 297 ASN B CB 1 ATOM 1771 C CG . ASN A 1 241 ? 26.602 15.883 0.892 1.00 22.60 ? 297 ASN B CG 1 ATOM 1772 O OD1 . ASN A 1 241 ? 27.108 14.757 0.954 1.00 2.06 ? 297 ASN B OD1 1 ATOM 1773 N ND2 . ASN A 1 241 ? 27.054 16.913 1.605 1.00 28.19 ? 297 ASN B ND2 1 ATOM 1774 N N . LEU A 1 242 ? 24.024 15.513 -3.260 1.00 17.44 ? 298 LEU B N 1 ATOM 1775 C CA . LEU A 1 242 ? 22.830 15.923 -4.002 1.00 12.35 ? 298 LEU B CA 1 ATOM 1776 C C . LEU A 1 242 ? 21.581 15.151 -3.624 1.00 7.13 ? 298 LEU B C 1 ATOM 1777 O O . LEU A 1 242 ? 21.559 13.916 -3.625 1.00 8.02 ? 298 LEU B O 1 ATOM 1778 C CB . LEU A 1 242 ? 23.054 15.798 -5.519 1.00 15.70 ? 298 LEU B CB 1 ATOM 1779 C CG . LEU A 1 242 ? 24.150 16.643 -6.175 1.00 15.51 ? 298 LEU B CG 1 ATOM 1780 C CD1 . LEU A 1 242 ? 24.226 16.361 -7.665 1.00 15.68 ? 298 LEU B CD1 1 ATOM 1781 C CD2 . LEU A 1 242 ? 23.888 18.104 -5.925 1.00 2.00 ? 298 LEU B CD2 1 ATOM 1782 N N . VAL A 1 243 ? 20.529 15.901 -3.334 1.00 7.27 ? 299 VAL B N 1 ATOM 1783 C CA . VAL A 1 243 ? 19.291 15.326 -2.825 1.00 20.91 ? 299 VAL B CA 1 ATOM 1784 C C . VAL A 1 243 ? 18.147 15.481 -3.875 1.00 16.98 ? 299 VAL B C 1 ATOM 1785 O O . VAL A 1 243 ? 18.354 16.061 -4.933 1.00 18.71 ? 299 VAL B O 1 ATOM 1786 C CB . VAL A 1 243 ? 18.974 15.976 -1.436 1.00 8.47 ? 299 VAL B CB 1 ATOM 1787 C CG1 . VAL A 1 243 ? 18.438 17.393 -1.602 1.00 22.99 ? 299 VAL B CG1 1 ATOM 1788 C CG2 . VAL A 1 243 ? 18.042 15.115 -0.645 1.00 15.30 ? 299 VAL B CG2 1 ATOM 1789 N N . GLY A 1 244 ? 16.955 14.960 -3.616 1.00 12.96 ? 300 GLY B N 1 ATOM 1790 C CA . GLY A 1 244 ? 15.844 15.209 -4.523 1.00 2.00 ? 300 GLY B CA 1 ATOM 1791 C C . GLY A 1 244 ? 15.726 14.363 -5.787 1.00 8.06 ? 300 GLY B C 1 ATOM 1792 O O . GLY A 1 244 ? 16.484 13.409 -6.021 1.00 5.75 ? 300 GLY B O 1 ATOM 1793 N N . LYS A 1 245 ? 14.757 14.733 -6.621 1.00 2.39 ? 301 LYS B N 1 ATOM 1794 C CA . LYS A 1 245 ? 14.494 14.027 -7.862 1.00 5.57 ? 301 LYS B CA 1 ATOM 1795 C C . LYS A 1 245 ? 15.351 14.534 -9.029 1.00 8.99 ? 301 LYS B C 1 ATOM 1796 O O . LYS A 1 245 ? 15.643 15.727 -9.112 1.00 9.43 ? 301 LYS B O 1 ATOM 1797 C CB . LYS A 1 245 ? 13.012 14.131 -8.200 1.00 9.51 ? 301 LYS B CB 1 ATOM 1798 C CG . LYS A 1 245 ? 12.490 15.530 -8.050 1.00 28.81 ? 301 LYS B CG 1 ATOM 1799 C CD . LYS A 1 245 ? 11.215 15.746 -8.837 1.00 35.93 ? 301 LYS B CD 1 ATOM 1800 C CE . LYS A 1 245 ? 10.124 14.791 -8.415 1.00 39.10 ? 301 LYS B CE 1 ATOM 1801 N NZ . LYS A 1 245 ? 8.834 15.244 -9.014 1.00 47.48 ? 301 LYS B NZ 1 ATOM 1802 N N . ILE A 1 246 ? 15.758 13.606 -9.907 1.00 13.50 ? 302 ILE B N 1 ATOM 1803 C CA . ILE A 1 246 ? 16.393 13.919 -11.193 1.00 10.01 ? 302 ILE B CA 1 ATOM 1804 C C . ILE A 1 246 ? 15.401 14.700 -12.051 1.00 2.00 ? 302 ILE B C 1 ATOM 1805 O O . ILE A 1 246 ? 14.271 14.254 -12.243 1.00 2.00 ? 302 ILE B O 1 ATOM 1806 C CB . ILE A 1 246 ? 16.779 12.621 -11.969 1.00 6.42 ? 302 ILE B CB 1 ATOM 1807 C CG1 . ILE A 1 246 ? 17.646 11.692 -11.115 1.00 7.09 ? 302 ILE B CG1 1 ATOM 1808 C CG2 . ILE A 1 246 ? 17.490 12.948 -13.282 1.00 8.87 ? 302 ILE B CG2 1 ATOM 1809 C CD1 . ILE A 1 246 ? 18.068 10.416 -11.821 1.00 2.00 ? 302 ILE B CD1 1 ATOM 1810 N N . PRO A 1 247 ? 15.809 15.878 -12.551 1.00 2.00 ? 303 PRO B N 1 ATOM 1811 C CA . PRO A 1 247 ? 14.905 16.707 -13.360 1.00 2.00 ? 303 PRO B CA 1 ATOM 1812 C C . PRO A 1 247 ? 14.562 16.079 -14.700 1.00 18.07 ? 303 PRO B C 1 ATOM 1813 O O . PRO A 1 247 ? 15.463 15.691 -15.450 1.00 19.65 ? 303 PRO B O 1 ATOM 1814 C CB . PRO A 1 247 ? 15.696 18.003 -13.575 1.00 2.00 ? 303 PRO B CB 1 ATOM 1815 C CG . PRO A 1 247 ? 17.108 17.665 -13.264 1.00 17.10 ? 303 PRO B CG 1 ATOM 1816 C CD . PRO A 1 247 ? 17.085 16.554 -12.260 1.00 5.59 ? 303 PRO B CD 1 ATOM 1817 N N . THR A 1 248 ? 13.272 16.018 -15.016 1.00 14.48 ? 304 THR B N 1 ATOM 1818 C CA . THR A 1 248 ? 12.824 15.435 -16.274 1.00 14.81 ? 304 THR B CA 1 ATOM 1819 C C . THR A 1 248 ? 13.232 16.285 -17.466 1.00 14.35 ? 304 THR B C 1 ATOM 1820 O O . THR A 1 248 ? 13.247 15.809 -18.605 1.00 14.43 ? 304 THR B O 1 ATOM 1821 C CB . THR A 1 248 ? 11.293 15.312 -16.331 1.00 16.83 ? 304 THR B CB 1 ATOM 1822 O OG1 . THR A 1 248 ? 10.711 16.621 -16.366 1.00 15.78 ? 304 THR B OG1 1 ATOM 1823 C CG2 . THR A 1 248 ? 10.773 14.544 -15.145 1.00 2.00 ? 304 THR B CG2 1 ATOM 1824 N N . GLU A 1 249 ? 13.536 17.551 -17.205 1.00 7.22 ? 305 GLU B N 1 ATOM 1825 C CA . GLU A 1 249 ? 13.904 18.473 -18.267 1.00 2.78 ? 305 GLU B CA 1 ATOM 1826 C C . GLU A 1 249 ? 15.253 18.127 -18.889 1.00 14.10 ? 305 GLU B C 1 ATOM 1827 O O . GLU A 1 249 ? 15.607 18.669 -19.933 1.00 25.70 ? 305 GLU B O 1 ATOM 1828 C CB . GLU A 1 249 ? 13.929 19.913 -17.765 1.00 2.00 ? 305 GLU B CB 1 ATOM 1829 C CG . GLU A 1 249 ? 12.566 20.473 -17.430 1.00 6.64 ? 305 GLU B CG 1 ATOM 1830 C CD . GLU A 1 249 ? 12.001 19.879 -16.164 1.00 15.91 ? 305 GLU B CD 1 ATOM 1831 O OE1 . GLU A 1 249 ? 12.809 19.479 -15.295 1.00 21.02 ? 305 GLU B OE1 1 ATOM 1832 O OE2 . GLU A 1 249 ? 10.758 19.800 -16.048 1.00 15.50 ? 305 GLU B OE2 1 ATOM 1833 N N . LEU A 1 250 ? 16.015 17.236 -18.260 1.00 10.81 ? 306 LEU B N 1 ATOM 1834 C CA . LEU A 1 250 ? 17.269 16.797 -18.866 1.00 12.44 ? 306 LEU B CA 1 ATOM 1835 C C . LEU A 1 250 ? 17.010 16.064 -20.191 1.00 20.59 ? 306 LEU B C 1 ATOM 1836 O O . LEU A 1 250 ? 17.923 15.879 -20.986 1.00 24.33 ? 306 LEU B O 1 ATOM 1837 C CB . LEU A 1 250 ? 18.072 15.898 -17.918 1.00 8.87 ? 306 LEU B CB 1 ATOM 1838 C CG . LEU A 1 250 ? 18.821 16.462 -16.706 1.00 13.06 ? 306 LEU B CG 1 ATOM 1839 C CD1 . LEU A 1 250 ? 19.571 15.331 -16.041 1.00 23.03 ? 306 LEU B CD1 1 ATOM 1840 C CD2 . LEU A 1 250 ? 19.796 17.559 -17.070 1.00 4.73 ? 306 LEU B CD2 1 ATOM 1841 N N . GLY A 1 251 ? 15.770 15.642 -20.425 1.00 18.67 ? 307 GLY B N 1 ATOM 1842 C CA . GLY A 1 251 ? 15.416 15.009 -21.683 1.00 18.99 ? 307 GLY B CA 1 ATOM 1843 C C . GLY A 1 251 ? 15.435 15.972 -22.864 1.00 18.09 ? 307 GLY B C 1 ATOM 1844 O O . GLY A 1 251 ? 15.462 15.548 -24.011 1.00 22.65 ? 307 GLY B O 1 ATOM 1845 N N . ASN A 1 252 ? 15.448 17.269 -22.564 1.00 16.44 ? 308 ASN B N 1 ATOM 1846 C CA . ASN A 1 252 ? 15.440 18.348 -23.553 1.00 11.13 ? 308 ASN B CA 1 ATOM 1847 C C . ASN A 1 252 ? 16.836 18.765 -24.007 1.00 16.57 ? 308 ASN B C 1 ATOM 1848 O O . ASN A 1 252 ? 17.001 19.820 -24.617 1.00 20.02 ? 308 ASN B O 1 ATOM 1849 C CB . ASN A 1 252 ? 14.729 19.583 -23.011 1.00 12.21 ? 308 ASN B CB 1 ATOM 1850 C CG . ASN A 1 252 ? 13.437 19.260 -22.304 1.00 14.45 ? 308 ASN B CG 1 ATOM 1851 O OD1 . ASN A 1 252 ? 12.843 18.195 -22.494 1.00 14.43 ? 308 ASN B OD1 1 ATOM 1852 N ND2 . ASN A 1 252 ? 12.983 20.197 -21.480 1.00 18.03 ? 308 ASN B ND2 1 ATOM 1853 N N . CYS A 1 253 ? 17.840 17.974 -23.645 1.00 19.42 ? 309 CYS B N 1 ATOM 1854 C CA . CYS A 1 253 ? 19.235 18.283 -23.955 1.00 23.36 ? 309 CYS B CA 1 ATOM 1855 C C . CYS A 1 253 ? 19.806 17.265 -24.950 1.00 24.66 ? 309 CYS B C 1 ATOM 1856 O O . CYS A 1 253 ? 20.460 16.295 -24.562 1.00 24.14 ? 309 CYS B O 1 ATOM 1857 C CB . CYS A 1 253 ? 20.079 18.289 -22.680 1.00 24.71 ? 309 CYS B CB 1 ATOM 1858 S SG . CYS A 1 253 ? 19.638 19.571 -21.500 1.00 11.97 ? 309 CYS B SG 1 ATOM 1859 N N . PRO A 1 254 ? 19.558 17.507 -26.247 1.00 14.26 ? 310 PRO B N 1 ATOM 1860 C CA . PRO A 1 254 ? 19.750 16.585 -27.370 1.00 4.76 ? 310 PRO B CA 1 ATOM 1861 C C . PRO A 1 254 ? 21.179 16.077 -27.508 1.00 10.71 ? 310 PRO B C 1 ATOM 1862 O O . PRO A 1 254 ? 21.392 14.917 -27.853 1.00 20.70 ? 310 PRO B O 1 ATOM 1863 C CB . PRO A 1 254 ? 19.391 17.442 -28.588 1.00 2.00 ? 310 PRO B CB 1 ATOM 1864 C CG . PRO A 1 254 ? 18.626 18.582 -28.058 1.00 8.99 ? 310 PRO B CG 1 ATOM 1865 C CD . PRO A 1 254 ? 19.198 18.856 -26.713 1.00 6.19 ? 310 PRO B CD 1 ATOM 1866 N N . GLU A 1 255 ? 22.153 16.927 -27.221 1.00 15.34 ? 311 GLU B N 1 ATOM 1867 C CA . GLU A 1 255 ? 23.545 16.569 -27.434 1.00 2.00 ? 311 GLU B CA 1 ATOM 1868 C C . GLU A 1 255 ? 24.174 15.848 -26.249 1.00 8.34 ? 311 GLU B C 1 ATOM 1869 O O . GLU A 1 255 ? 25.378 15.606 -26.256 1.00 14.92 ? 311 GLU B O 1 ATOM 1870 C CB . GLU A 1 255 ? 24.357 17.812 -27.754 1.00 27.78 ? 311 GLU B CB 1 ATOM 1871 C CG . GLU A 1 255 ? 23.976 18.474 -29.051 1.00 33.10 ? 311 GLU B CG 1 ATOM 1872 C CD . GLU A 1 255 ? 24.905 19.612 -29.404 1.00 47.39 ? 311 GLU B CD 1 ATOM 1873 O OE1 . GLU A 1 255 ? 25.822 19.906 -28.606 1.00 49.10 ? 311 GLU B OE1 1 ATOM 1874 O OE2 . GLU A 1 255 ? 24.722 20.217 -30.479 1.00 59.57 ? 311 GLU B OE2 1 ATOM 1875 N N . LEU A 1 256 ? 23.375 15.496 -25.239 1.00 2.00 ? 312 LEU B N 1 ATOM 1876 C CA . LEU A 1 256 ? 23.927 15.052 -23.974 1.00 2.00 ? 312 LEU B CA 1 ATOM 1877 C C . LEU A 1 256 ? 24.151 13.554 -24.038 1.00 8.09 ? 312 LEU B C 1 ATOM 1878 O O . LEU A 1 256 ? 23.223 12.766 -23.974 1.00 2.00 ? 312 LEU B O 1 ATOM 1879 C CB . LEU A 1 256 ? 22.938 15.385 -22.847 1.00 2.00 ? 312 LEU B CB 1 ATOM 1880 C CG . LEU A 1 256 ? 23.088 14.860 -21.396 1.00 16.83 ? 312 LEU B CG 1 ATOM 1881 C CD1 . LEU A 1 256 ? 24.154 15.579 -20.595 1.00 13.32 ? 312 LEU B CD1 1 ATOM 1882 C CD2 . LEU A 1 256 ? 21.773 14.942 -20.663 1.00 2.00 ? 312 LEU B CD2 1 ATOM 1883 N N . TRP A 1 257 ? 25.414 13.177 -24.164 1.00 2.00 ? 313 TRP B N 1 ATOM 1884 C CA . TRP A 1 257 ? 25.796 11.778 -24.272 1.00 12.26 ? 313 TRP B CA 1 ATOM 1885 C C . TRP A 1 257 ? 26.275 11.157 -22.952 1.00 11.23 ? 313 TRP B C 1 ATOM 1886 O O . TRP A 1 257 ? 26.361 9.932 -22.831 1.00 13.53 ? 313 TRP B O 1 ATOM 1887 C CB . TRP A 1 257 ? 26.890 11.635 -25.346 1.00 8.91 ? 313 TRP B CB 1 ATOM 1888 C CG . TRP A 1 257 ? 28.166 12.285 -24.951 1.00 4.32 ? 313 TRP B CG 1 ATOM 1889 C CD1 . TRP A 1 257 ? 28.460 13.604 -25.031 1.00 2.00 ? 313 TRP B CD1 1 ATOM 1890 C CD2 . TRP A 1 257 ? 29.306 11.649 -24.377 1.00 2.00 ? 313 TRP B CD2 1 ATOM 1891 N NE1 . TRP A 1 257 ? 29.716 13.835 -24.545 1.00 2.00 ? 313 TRP B NE1 1 ATOM 1892 C CE2 . TRP A 1 257 ? 30.261 12.640 -24.135 1.00 2.01 ? 313 TRP B CE2 1 ATOM 1893 C CE3 . TRP A 1 257 ? 29.614 10.331 -24.036 1.00 13.93 ? 313 TRP B CE3 1 ATOM 1894 C CZ2 . TRP A 1 257 ? 31.500 12.370 -23.576 1.00 2.38 ? 313 TRP B CZ2 1 ATOM 1895 C CZ3 . TRP A 1 257 ? 30.853 10.057 -23.483 1.00 2.30 ? 313 TRP B CZ3 1 ATOM 1896 C CH2 . TRP A 1 257 ? 31.780 11.072 -23.264 1.00 2.51 ? 313 TRP B CH2 1 ATOM 1897 N N . LEU A 1 258 ? 26.567 11.991 -21.960 1.00 9.11 ? 314 LEU B N 1 ATOM 1898 C CA . LEU A 1 258 ? 27.100 11.475 -20.691 1.00 14.50 ? 314 LEU B CA 1 ATOM 1899 C C . LEU A 1 258 ? 26.460 12.077 -19.429 1.00 8.08 ? 314 LEU B C 1 ATOM 1900 O O . LEU A 1 258 ? 26.430 13.300 -19.241 1.00 2.00 ? 314 LEU B O 1 ATOM 1901 C CB . LEU A 1 258 ? 28.622 11.627 -20.648 1.00 21.84 ? 314 LEU B CB 1 ATOM 1902 C CG . LEU A 1 258 ? 29.317 11.148 -19.373 1.00 19.11 ? 314 LEU B CG 1 ATOM 1903 C CD1 . LEU A 1 258 ? 28.876 9.755 -18.994 1.00 15.99 ? 314 LEU B CD1 1 ATOM 1904 C CD2 . LEU A 1 258 ? 30.817 11.181 -19.541 1.00 20.25 ? 314 LEU B CD2 1 ATOM 1905 N N . ILE A 1 259 ? 25.939 11.202 -18.575 1.00 9.04 ? 315 ILE B N 1 ATOM 1906 C CA . ILE A 1 259 ? 25.333 11.624 -17.307 1.00 8.44 ? 315 ILE B CA 1 ATOM 1907 C C . ILE A 1 259 ? 25.854 10.780 -16.146 1.00 11.81 ? 315 ILE B C 1 ATOM 1908 O O . ILE A 1 259 ? 25.625 9.561 -16.120 1.00 9.04 ? 315 ILE B O 1 ATOM 1909 C CB . ILE A 1 259 ? 23.802 11.469 -17.342 1.00 6.04 ? 315 ILE B CB 1 ATOM 1910 C CG1 . ILE A 1 259 ? 23.212 12.147 -18.588 1.00 9.83 ? 315 ILE B CG1 1 ATOM 1911 C CG2 . ILE A 1 259 ? 23.181 12.000 -16.056 1.00 4.33 ? 315 ILE B CG2 1 ATOM 1912 C CD1 . ILE A 1 259 ? 21.703 11.972 -18.722 1.00 8.95 ? 315 ILE B CD1 1 ATOM 1913 N N . ASP A 1 260 ? 26.571 11.403 -15.204 1.00 11.99 ? 316 ASP B N 1 ATOM 1914 C CA . ASP A 1 260 ? 26.963 10.696 -13.981 1.00 11.21 ? 316 ASP B CA 1 ATOM 1915 C C . ASP A 1 260 ? 26.481 11.387 -12.705 1.00 11.18 ? 316 ASP B C 1 ATOM 1916 O O . ASP A 1 260 ? 27.016 12.423 -12.287 1.00 4.62 ? 316 ASP B O 1 ATOM 1917 C CB . ASP A 1 260 ? 28.479 10.550 -13.930 1.00 14.58 ? 316 ASP B CB 1 ATOM 1918 C CG . ASP A 1 260 ? 28.929 9.417 -13.028 1.00 21.77 ? 316 ASP B CG 1 ATOM 1919 O OD1 . ASP A 1 260 ? 28.235 9.135 -12.031 1.00 23.96 ? 316 ASP B OD1 1 ATOM 1920 O OD2 . ASP A 1 260 ? 29.979 8.805 -13.316 1.00 19.89 ? 316 ASP B OD2 1 ATOM 1921 N N . PHE A 1 261 ? 25.462 10.791 -12.098 1.00 16.60 ? 317 PHE B N 1 ATOM 1922 C CA . PHE A 1 261 ? 24.949 11.159 -10.777 1.00 2.00 ? 317 PHE B CA 1 ATOM 1923 C C . PHE A 1 261 ? 25.371 10.182 -9.672 1.00 12.61 ? 317 PHE B C 1 ATOM 1924 O O . PHE A 1 261 ? 24.862 10.241 -8.552 1.00 6.05 ? 317 PHE B O 1 ATOM 1925 C CB . PHE A 1 261 ? 23.443 11.386 -10.821 1.00 2.00 ? 317 PHE B CB 1 ATOM 1926 C CG . PHE A 1 261 ? 23.040 12.474 -11.776 1.00 16.08 ? 317 PHE B CG 1 ATOM 1927 C CD1 . PHE A 1 261 ? 23.958 13.437 -12.165 1.00 2.00 ? 317 PHE B CD1 1 ATOM 1928 C CD2 . PHE A 1 261 ? 21.759 12.531 -12.297 1.00 3.36 ? 317 PHE B CD2 1 ATOM 1929 C CE1 . PHE A 1 261 ? 23.606 14.437 -13.043 1.00 18.69 ? 317 PHE B CE1 1 ATOM 1930 C CE2 . PHE A 1 261 ? 21.402 13.536 -13.185 1.00 4.52 ? 317 PHE B CE2 1 ATOM 1931 C CZ . PHE A 1 261 ? 22.329 14.492 -13.558 1.00 2.00 ? 317 PHE B CZ 1 ATOM 1932 N N . SER A 1 262 ? 26.256 9.250 -10.002 1.00 2.00 ? 318 SER B N 1 ATOM 1933 C CA . SER A 1 262 ? 26.613 8.194 -9.069 1.00 8.52 ? 318 SER B CA 1 ATOM 1934 C C . SER A 1 262 ? 27.030 8.713 -7.681 1.00 6.95 ? 318 SER B C 1 ATOM 1935 O O . SER A 1 262 ? 27.626 9.776 -7.577 1.00 2.00 ? 318 SER B O 1 ATOM 1936 C CB . SER A 1 262 ? 27.740 7.341 -9.650 1.00 9.97 ? 318 SER B CB 1 ATOM 1937 O OG . SER A 1 262 ? 27.433 6.875 -10.951 1.00 7.34 ? 318 SER B OG 1 ATOM 1938 N N . GLU A 1 263 ? 26.673 7.967 -6.629 1.00 5.76 ? 319 GLU B N 1 ATOM 1939 C CA . GLU A 1 263 ? 26.991 8.297 -5.230 1.00 2.00 ? 319 GLU B CA 1 ATOM 1940 C C . GLU A 1 263 ? 26.509 9.643 -4.739 1.00 4.51 ? 319 GLU B C 1 ATOM 1941 O O . GLU A 1 263 ? 27.296 10.528 -4.430 1.00 2.00 ? 319 GLU B O 1 ATOM 1942 C CB . GLU A 1 263 ? 28.468 8.117 -4.923 1.00 2.00 ? 319 GLU B CB 1 ATOM 1943 C CG . GLU A 1 263 ? 28.929 6.696 -5.149 1.00 30.56 ? 319 GLU B CG 1 ATOM 1944 C CD . GLU A 1 263 ? 30.339 6.477 -4.703 1.00 32.04 ? 319 GLU B CD 1 ATOM 1945 O OE1 . GLU A 1 263 ? 31.010 5.582 -5.259 1.00 34.47 ? 319 GLU B OE1 1 ATOM 1946 O OE2 . GLU A 1 263 ? 30.771 7.202 -3.784 1.00 35.64 ? 319 GLU B OE2 1 ATOM 1947 N N . ASN A 1 264 ? 25.193 9.761 -4.652 1.00 2.00 ? 320 ASN B N 1 ATOM 1948 C CA . ASN A 1 264 ? 24.522 10.896 -4.059 1.00 2.00 ? 320 ASN B CA 1 ATOM 1949 C C . ASN A 1 264 ? 23.337 10.362 -3.253 1.00 11.31 ? 320 ASN B C 1 ATOM 1950 O O . ASN A 1 264 ? 23.276 9.185 -2.907 1.00 7.75 ? 320 ASN B O 1 ATOM 1951 C CB . ASN A 1 264 ? 24.024 11.888 -5.112 1.00 2.00 ? 320 ASN B CB 1 ATOM 1952 C CG . ASN A 1 264 ? 25.152 12.616 -5.835 1.00 18.69 ? 320 ASN B CG 1 ATOM 1953 O OD1 . ASN A 1 264 ? 25.502 13.735 -5.477 1.00 25.93 ? 320 ASN B OD1 1 ATOM 1954 N ND2 . ASN A 1 264 ? 25.701 11.994 -6.875 1.00 16.57 ? 320 ASN B ND2 1 ATOM 1955 N N . LEU A 1 265 ? 22.455 11.264 -2.858 1.00 2.00 ? 321 LEU B N 1 ATOM 1956 C CA . LEU A 1 265 ? 21.246 10.920 -2.128 1.00 17.78 ? 321 LEU B CA 1 ATOM 1957 C C . LEU A 1 265 ? 19.928 10.903 -2.927 1.00 13.76 ? 321 LEU B C 1 ATOM 1958 O O . LEU A 1 265 ? 18.854 10.866 -2.343 1.00 24.67 ? 321 LEU B O 1 ATOM 1959 C CB . LEU A 1 265 ? 21.157 11.740 -0.839 1.00 22.52 ? 321 LEU B CB 1 ATOM 1960 C CG . LEU A 1 265 ? 22.402 11.504 0.025 1.00 15.10 ? 321 LEU B CG 1 ATOM 1961 C CD1 . LEU A 1 265 ? 22.581 12.625 1.017 1.00 5.94 ? 321 LEU B CD1 1 ATOM 1962 C CD2 . LEU A 1 265 ? 22.347 10.144 0.732 1.00 14.06 ? 321 LEU B CD2 1 ATOM 1963 N N . LEU A 1 266 ? 19.999 10.994 -4.244 1.00 15.20 ? 322 LEU B N 1 ATOM 1964 C CA . LEU A 1 266 ? 18.805 11.261 -5.047 1.00 14.90 ? 322 LEU B CA 1 ATOM 1965 C C . LEU A 1 266 ? 17.649 10.299 -4.763 1.00 11.95 ? 322 LEU B C 1 ATOM 1966 O O . LEU A 1 266 ? 17.872 9.161 -4.353 1.00 12.81 ? 322 LEU B O 1 ATOM 1967 C CB . LEU A 1 266 ? 19.157 11.251 -6.542 1.00 8.05 ? 322 LEU B CB 1 ATOM 1968 C CG . LEU A 1 266 ? 20.289 12.187 -6.985 1.00 4.93 ? 322 LEU B CG 1 ATOM 1969 C CD1 . LEU A 1 266 ? 20.612 11.991 -8.451 1.00 2.37 ? 322 LEU B CD1 1 ATOM 1970 C CD2 . LEU A 1 266 ? 19.926 13.638 -6.704 1.00 2.00 ? 322 LEU B CD2 1 ATOM 1971 N N . THR A 1 267 ? 16.424 10.804 -4.921 1.00 8.92 ? 323 THR B N 1 ATOM 1972 C CA . THR A 1 267 ? 15.188 10.016 -4.841 1.00 11.10 ? 323 THR B CA 1 ATOM 1973 C C . THR A 1 267 ? 14.329 10.305 -6.069 1.00 9.91 ? 323 THR B C 1 ATOM 1974 O O . THR A 1 267 ? 14.587 11.240 -6.804 1.00 11.76 ? 323 THR B O 1 ATOM 1975 C CB . THR A 1 267 ? 14.328 10.377 -3.612 1.00 2.00 ? 323 THR B CB 1 ATOM 1976 O OG1 . THR A 1 267 ? 14.184 11.796 -3.560 1.00 7.93 ? 323 THR B OG1 1 ATOM 1977 C CG2 . THR A 1 267 ? 14.966 9.898 -2.347 1.00 2.00 ? 323 THR B CG2 1 ATOM 1978 N N . GLY A 1 268 ? 13.284 9.523 -6.275 1.00 2.00 ? 324 GLY B N 1 ATOM 1979 C CA . GLY A 1 268 ? 12.461 9.700 -7.448 1.00 6.20 ? 324 GLY B CA 1 ATOM 1980 C C . GLY A 1 268 ? 12.687 8.617 -8.479 1.00 13.79 ? 324 GLY B C 1 ATOM 1981 O O . GLY A 1 268 ? 13.330 7.597 -8.220 1.00 16.38 ? 324 GLY B O 1 ATOM 1982 N N . THR A 1 269 ? 12.146 8.857 -9.661 1.00 15.92 ? 325 THR B N 1 ATOM 1983 C CA . THR A 1 269 ? 12.114 7.890 -10.740 1.00 15.21 ? 325 THR B CA 1 ATOM 1984 C C . THR A 1 269 ? 13.148 8.281 -11.785 1.00 20.69 ? 325 THR B C 1 ATOM 1985 O O . THR A 1 269 ? 13.433 9.464 -11.943 1.00 21.55 ? 325 THR B O 1 ATOM 1986 C CB . THR A 1 269 ? 10.709 7.922 -11.355 1.00 18.64 ? 325 THR B CB 1 ATOM 1987 O OG1 . THR A 1 269 ? 9.813 7.244 -10.473 1.00 20.10 ? 325 THR B OG1 1 ATOM 1988 C CG2 . THR A 1 269 ? 10.657 7.263 -12.727 1.00 27.56 ? 325 THR B CG2 1 ATOM 1989 N N . ILE A 1 270 ? 13.745 7.297 -12.462 1.00 22.68 ? 326 ILE B N 1 ATOM 1990 C CA . ILE A 1 270 ? 14.488 7.585 -13.683 1.00 14.91 ? 326 ILE B CA 1 ATOM 1991 C C . ILE A 1 270 ? 13.485 8.122 -14.688 1.00 8.39 ? 326 ILE B C 1 ATOM 1992 O O . ILE A 1 270 ? 12.574 7.399 -15.098 1.00 8.57 ? 326 ILE B O 1 ATOM 1993 C CB . ILE A 1 270 ? 15.101 6.321 -14.307 1.00 15.23 ? 326 ILE B CB 1 ATOM 1994 C CG1 . ILE A 1 270 ? 16.084 5.651 -13.353 1.00 2.00 ? 326 ILE B CG1 1 ATOM 1995 C CG2 . ILE A 1 270 ? 15.785 6.664 -15.629 1.00 3.96 ? 326 ILE B CG2 1 ATOM 1996 C CD1 . ILE A 1 270 ? 16.613 4.351 -13.872 1.00 2.00 ? 326 ILE B CD1 1 ATOM 1997 N N . PRO A 1 271 ? 13.650 9.388 -15.093 1.00 9.77 ? 327 PRO B N 1 ATOM 1998 C CA . PRO A 1 271 ? 12.707 10.096 -15.977 1.00 9.06 ? 327 PRO B CA 1 ATOM 1999 C C . PRO A 1 271 ? 12.432 9.405 -17.318 1.00 16.72 ? 327 PRO B C 1 ATOM 2000 O O . PRO A 1 271 ? 13.348 8.923 -17.986 1.00 24.22 ? 327 PRO B O 1 ATOM 2001 C CB . PRO A 1 271 ? 13.397 11.442 -16.211 1.00 11.73 ? 327 PRO B CB 1 ATOM 2002 C CG . PRO A 1 271 ? 14.261 11.637 -14.998 1.00 13.72 ? 327 PRO B CG 1 ATOM 2003 C CD . PRO A 1 271 ? 14.753 10.259 -14.649 1.00 14.35 ? 327 PRO B CD 1 ATOM 2004 N N . ARG A 1 272 ? 11.162 9.371 -17.706 1.00 15.56 ? 328 ARG B N 1 ATOM 2005 C CA . ARG A 1 272 ? 10.763 8.818 -18.995 1.00 11.88 ? 328 ARG B CA 1 ATOM 2006 C C . ARG A 1 272 ? 11.215 9.721 -20.141 1.00 22.42 ? 328 ARG B C 1 ATOM 2007 O O . ARG A 1 272 ? 11.312 9.274 -21.287 1.00 32.87 ? 328 ARG B O 1 ATOM 2008 C CB . ARG A 1 272 ? 9.240 8.599 -19.054 1.00 7.60 ? 328 ARG B CB 1 ATOM 2009 C CG . ARG A 1 272 ? 8.751 7.396 -18.241 1.00 14.23 ? 328 ARG B CG 1 ATOM 2010 C CD . ARG A 1 272 ? 7.221 7.244 -18.228 1.00 26.76 ? 328 ARG B CD 1 ATOM 2011 N NE . ARG A 1 272 ? 6.523 8.436 -17.741 1.00 36.39 ? 328 ARG B NE 1 ATOM 2012 C CZ . ARG A 1 272 ? 6.029 9.385 -18.535 1.00 42.31 ? 328 ARG B CZ 1 ATOM 2013 N NH1 . ARG A 1 272 ? 6.158 9.276 -19.857 1.00 47.80 ? 328 ARG B NH1 1 ATOM 2014 N NH2 . ARG A 1 272 ? 5.413 10.444 -18.015 1.00 32.39 ? 328 ARG B NH2 1 ATOM 2015 N N . SER A 1 273 ? 11.493 10.987 -19.842 1.00 2.00 ? 329 SER B N 1 ATOM 2016 C CA . SER A 1 273 ? 11.973 11.903 -20.871 1.00 2.00 ? 329 SER B CA 1 ATOM 2017 C C . SER A 1 273 ? 13.346 11.502 -21.424 1.00 7.61 ? 329 SER B C 1 ATOM 2018 O O . SER A 1 273 ? 13.725 11.920 -22.522 1.00 14.65 ? 329 SER B O 1 ATOM 2019 C CB . SER A 1 273 ? 11.994 13.342 -20.364 1.00 10.31 ? 329 SER B CB 1 ATOM 2020 O OG . SER A 1 273 ? 12.611 13.439 -19.095 1.00 13.49 ? 329 SER B OG 1 ATOM 2021 N N . PHE A 1 274 ? 14.074 10.682 -20.667 1.00 3.98 ? 330 PHE B N 1 ATOM 2022 C CA . PHE A 1 274 ? 15.390 10.187 -21.078 1.00 9.81 ? 330 PHE B CA 1 ATOM 2023 C C . PHE A 1 274 ? 15.329 9.469 -22.436 1.00 9.59 ? 330 PHE B C 1 ATOM 2024 O O . PHE A 1 274 ? 16.331 9.375 -23.154 1.00 9.75 ? 330 PHE B O 1 ATOM 2025 C CB . PHE A 1 274 ? 15.990 9.247 -20.010 1.00 10.09 ? 330 PHE B CB 1 ATOM 2026 C CG . PHE A 1 274 ? 16.767 9.952 -18.922 1.00 10.55 ? 330 PHE B CG 1 ATOM 2027 C CD1 . PHE A 1 274 ? 16.587 11.306 -18.665 1.00 11.55 ? 330 PHE B CD1 1 ATOM 2028 C CD2 . PHE A 1 274 ? 17.683 9.254 -18.147 1.00 11.61 ? 330 PHE B CD2 1 ATOM 2029 C CE1 . PHE A 1 274 ? 17.309 11.946 -17.654 1.00 5.32 ? 330 PHE B CE1 1 ATOM 2030 C CE2 . PHE A 1 274 ? 18.401 9.897 -17.126 1.00 6.21 ? 330 PHE B CE2 1 ATOM 2031 C CZ . PHE A 1 274 ? 18.212 11.235 -16.891 1.00 2.00 ? 330 PHE B CZ 1 ATOM 2032 N N . GLY A 1 275 ? 14.154 8.958 -22.782 1.00 6.09 ? 331 GLY B N 1 ATOM 2033 C CA . GLY A 1 275 ? 13.984 8.295 -24.060 1.00 7.41 ? 331 GLY B CA 1 ATOM 2034 C C . GLY A 1 275 ? 14.288 9.248 -25.202 1.00 8.22 ? 331 GLY B C 1 ATOM 2035 O O . GLY A 1 275 ? 14.822 8.856 -26.232 1.00 13.59 ? 331 GLY B O 1 ATOM 2036 N N . LYS A 1 276 ? 13.958 10.516 -24.998 1.00 3.83 ? 332 LYS B N 1 ATOM 2037 C CA . LYS A 1 276 ? 14.196 11.542 -25.987 1.00 5.26 ? 332 LYS B CA 1 ATOM 2038 C C . LYS A 1 276 ? 15.685 11.776 -26.241 1.00 17.35 ? 332 LYS B C 1 ATOM 2039 O O . LYS A 1 276 ? 16.038 12.531 -27.163 1.00 16.26 ? 332 LYS B O 1 ATOM 2040 C CB . LYS A 1 276 ? 13.585 12.864 -25.536 1.00 8.82 ? 332 LYS B CB 1 ATOM 2041 C CG . LYS A 1 276 ? 12.100 12.863 -25.263 1.00 22.30 ? 332 LYS B CG 1 ATOM 2042 C CD . LYS A 1 276 ? 11.669 14.256 -24.771 1.00 39.95 ? 332 LYS B CD 1 ATOM 2043 C CE . LYS A 1 276 ? 10.148 14.428 -24.760 1.00 60.77 ? 332 LYS B CE 1 ATOM 2044 N NZ . LYS A 1 276 ? 9.556 14.571 -26.136 1.00 72.41 ? 332 LYS B NZ 1 ATOM 2045 N N . LEU A 1 277 ? 16.566 11.171 -25.438 1.00 16.97 ? 333 LEU B N 1 ATOM 2046 C CA . LEU A 1 277 ? 17.976 11.531 -25.552 1.00 16.47 ? 333 LEU B CA 1 ATOM 2047 C C . LEU A 1 277 ? 18.668 10.590 -26.506 1.00 18.75 ? 333 LEU B C 1 ATOM 2048 O O . LEU A 1 277 ? 19.090 9.498 -26.121 1.00 13.71 ? 333 LEU B O 1 ATOM 2049 C CB . LEU A 1 277 ? 18.662 11.448 -24.189 1.00 16.03 ? 333 LEU B CB 1 ATOM 2050 C CG . LEU A 1 277 ? 18.297 12.475 -23.110 1.00 11.92 ? 333 LEU B CG 1 ATOM 2051 C CD1 . LEU A 1 277 ? 19.151 12.259 -21.870 1.00 10.29 ? 333 LEU B CD1 1 ATOM 2052 C CD2 . LEU A 1 277 ? 18.448 13.899 -23.628 1.00 5.78 ? 333 LEU B CD2 1 ATOM 2053 N N . GLU A 1 278 ? 18.899 11.088 -27.718 1.00 25.27 ? 334 GLU B N 1 ATOM 2054 C CA . GLU A 1 278 ? 19.277 10.257 -28.857 1.00 11.12 ? 334 GLU B CA 1 ATOM 2055 C C . GLU A 1 278 ? 20.744 9.901 -28.792 1.00 6.67 ? 334 GLU B C 1 ATOM 2056 O O . GLU A 1 278 ? 21.154 8.856 -29.274 1.00 14.78 ? 334 GLU B O 1 ATOM 2057 C CB . GLU A 1 278 ? 18.998 11.007 -30.160 1.00 20.52 ? 334 GLU B CB 1 ATOM 2058 C CG . GLU A 1 278 ? 17.627 11.679 -30.238 1.00 34.08 ? 334 GLU B CG 1 ATOM 2059 C CD . GLU A 1 278 ? 16.601 10.849 -31.000 1.00 40.12 ? 334 GLU B CD 1 ATOM 2060 O OE1 . GLU A 1 278 ? 16.874 10.499 -32.168 1.00 32.34 ? 334 GLU B OE1 1 ATOM 2061 O OE2 . GLU A 1 278 ? 15.524 10.547 -30.429 1.00 48.44 ? 334 GLU B OE2 1 ATOM 2062 N N . ASN A 1 279 ? 21.532 10.786 -28.193 1.00 11.51 ? 335 ASN B N 1 ATOM 2063 C CA . ASN A 1 279 ? 22.978 10.611 -28.107 1.00 9.95 ? 335 ASN B CA 1 ATOM 2064 C C . ASN A 1 279 ? 23.564 10.013 -26.828 1.00 9.07 ? 335 ASN B C 1 ATOM 2065 O O . ASN A 1 279 ? 24.785 9.949 -26.713 1.00 7.90 ? 335 ASN B O 1 ATOM 2066 C CB . ASN A 1 279 ? 23.685 11.923 -28.430 1.00 8.76 ? 335 ASN B CB 1 ATOM 2067 C CG . ASN A 1 279 ? 23.200 12.522 -29.729 1.00 9.89 ? 335 ASN B CG 1 ATOM 2068 O OD1 . ASN A 1 279 ? 22.913 13.720 -29.815 1.00 9.38 ? 335 ASN B OD1 1 ATOM 2069 N ND2 . ASN A 1 279 ? 23.078 11.681 -30.746 1.00 8.37 ? 335 ASN B ND2 1 ATOM 2070 N N . LEU A 1 280 ? 22.725 9.576 -25.880 1.00 10.68 ? 336 LEU B N 1 ATOM 2071 C CA . LEU A 1 280 ? 23.233 9.130 -24.582 1.00 2.00 ? 336 LEU B CA 1 ATOM 2072 C C . LEU A 1 280 ? 24.024 7.828 -24.773 1.00 7.76 ? 336 LEU B C 1 ATOM 2073 O O . LEU A 1 280 ? 23.477 6.812 -25.200 1.00 5.23 ? 336 LEU B O 1 ATOM 2074 C CB . LEU A 1 280 ? 22.044 8.899 -23.642 1.00 2.00 ? 336 LEU B CB 1 ATOM 2075 C CG . LEU A 1 280 ? 22.124 8.511 -22.143 1.00 9.74 ? 336 LEU B CG 1 ATOM 2076 C CD1 . LEU A 1 280 ? 22.585 9.673 -21.278 1.00 2.00 ? 336 LEU B CD1 1 ATOM 2077 C CD2 . LEU A 1 280 ? 20.803 7.983 -21.629 1.00 2.00 ? 336 LEU B CD2 1 ATOM 2078 N N . GLN A 1 281 ? 25.327 7.884 -24.500 1.00 2.00 ? 337 GLN B N 1 ATOM 2079 C CA . GLN A 1 281 ? 26.189 6.698 -24.462 1.00 14.58 ? 337 GLN B CA 1 ATOM 2080 C C . GLN A 1 281 ? 26.259 6.052 -23.081 1.00 19.15 ? 337 GLN B C 1 ATOM 2081 O O . GLN A 1 281 ? 26.321 4.828 -22.941 1.00 20.41 ? 337 GLN B O 1 ATOM 2082 C CB . GLN A 1 281 ? 27.606 7.005 -24.965 1.00 10.42 ? 337 GLN B CB 1 ATOM 2083 C CG . GLN A 1 281 ? 27.671 8.001 -26.096 1.00 16.86 ? 337 GLN B CG 1 ATOM 2084 C CD . GLN A 1 281 ? 28.968 7.910 -26.869 1.00 20.10 ? 337 GLN B CD 1 ATOM 2085 O OE1 . GLN A 1 281 ? 29.923 7.265 -26.442 1.00 14.85 ? 337 GLN B OE1 1 ATOM 2086 N NE2 . GLN A 1 281 ? 29.001 8.549 -28.022 1.00 29.43 ? 337 GLN B NE2 1 ATOM 2087 N N . GLU A 1 282 ? 26.327 6.899 -22.061 1.00 19.03 ? 338 GLU B N 1 ATOM 2088 C CA . GLU A 1 282 ? 26.600 6.419 -20.714 1.00 22.46 ? 338 GLU B CA 1 ATOM 2089 C C . GLU A 1 282 ? 25.682 7.051 -19.671 1.00 9.25 ? 338 GLU B C 1 ATOM 2090 O O . GLU A 1 282 ? 25.578 8.273 -19.579 1.00 5.62 ? 338 GLU B O 1 ATOM 2091 C CB . GLU A 1 282 ? 28.070 6.650 -20.379 1.00 29.62 ? 338 GLU B CB 1 ATOM 2092 C CG . GLU A 1 282 ? 28.494 6.138 -19.017 1.00 37.65 ? 338 GLU B CG 1 ATOM 2093 C CD . GLU A 1 282 ? 29.987 5.863 -18.954 1.00 47.22 ? 338 GLU B CD 1 ATOM 2094 O OE1 . GLU A 1 282 ? 30.672 6.082 -19.994 1.00 49.11 ? 338 GLU B OE1 1 ATOM 2095 O OE2 . GLU A 1 282 ? 30.463 5.421 -17.877 1.00 43.84 ? 338 GLU B OE2 1 ATOM 2096 N N . LEU A 1 283 ? 24.991 6.207 -18.914 1.00 3.01 ? 339 LEU B N 1 ATOM 2097 C CA . LEU A 1 283 ? 24.109 6.676 -17.839 1.00 7.13 ? 339 LEU B CA 1 ATOM 2098 C C . LEU A 1 283 ? 24.485 6.014 -16.516 1.00 8.52 ? 339 LEU B C 1 ATOM 2099 O O . LEU A 1 283 ? 24.306 4.802 -16.340 1.00 5.77 ? 339 LEU B O 1 ATOM 2100 C CB . LEU A 1 283 ? 22.649 6.369 -18.156 1.00 5.79 ? 339 LEU B CB 1 ATOM 2101 C CG . LEU A 1 283 ? 21.595 6.800 -17.140 1.00 2.00 ? 339 LEU B CG 1 ATOM 2102 C CD1 . LEU A 1 283 ? 21.797 8.236 -16.725 1.00 19.45 ? 339 LEU B CD1 1 ATOM 2103 C CD2 . LEU A 1 283 ? 20.214 6.618 -17.744 1.00 8.33 ? 339 LEU B CD2 1 ATOM 2104 N N . GLN A 1 284 ? 25.003 6.817 -15.592 1.00 5.31 ? 340 GLN B N 1 ATOM 2105 C CA . GLN A 1 284 ? 25.504 6.299 -14.336 1.00 2.00 ? 340 GLN B CA 1 ATOM 2106 C C . GLN A 1 284 ? 24.743 6.945 -13.173 1.00 4.65 ? 340 GLN B C 1 ATOM 2107 O O . GLN A 1 284 ? 24.804 8.165 -12.993 1.00 5.23 ? 340 GLN B O 1 ATOM 2108 C CB . GLN A 1 284 ? 27.002 6.564 -14.264 1.00 2.00 ? 340 GLN B CB 1 ATOM 2109 C CG . GLN A 1 284 ? 27.839 5.633 -15.134 1.00 4.28 ? 340 GLN B CG 1 ATOM 2110 C CD . GLN A 1 284 ? 29.135 5.223 -14.438 1.00 24.62 ? 340 GLN B CD 1 ATOM 2111 O OE1 . GLN A 1 284 ? 29.770 6.025 -13.748 1.00 23.92 ? 340 GLN B OE1 1 ATOM 2112 N NE2 . GLN A 1 284 ? 29.517 3.960 -14.596 1.00 35.48 ? 340 GLN B NE2 1 ATOM 2113 N N . LEU A 1 285 ? 23.897 6.137 -12.524 1.00 2.36 ? 341 LEU B N 1 ATOM 2114 C CA . LEU A 1 285 ? 23.119 6.467 -11.316 1.00 3.67 ? 341 LEU B CA 1 ATOM 2115 C C . LEU A 1 285 ? 23.501 5.728 -10.011 1.00 4.77 ? 341 LEU B C 1 ATOM 2116 O O . LEU A 1 285 ? 22.817 5.842 -8.985 1.00 3.56 ? 341 LEU B O 1 ATOM 2117 C CB . LEU A 1 285 ? 21.618 6.386 -11.604 1.00 2.00 ? 341 LEU B CB 1 ATOM 2118 C CG . LEU A 1 285 ? 21.278 7.239 -12.832 1.00 2.00 ? 341 LEU B CG 1 ATOM 2119 C CD1 . LEU A 1 285 ? 19.831 7.051 -13.272 1.00 2.00 ? 341 LEU B CD1 1 ATOM 2120 C CD2 . LEU A 1 285 ? 21.613 8.722 -12.601 1.00 2.00 ? 341 LEU B CD2 1 ATOM 2121 N N . SER A 1 286 ? 24.552 4.926 -10.071 1.00 7.87 ? 342 SER B N 1 ATOM 2122 C CA . SER A 1 286 ? 24.897 4.025 -8.980 1.00 5.87 ? 342 SER B CA 1 ATOM 2123 C C . SER A 1 286 ? 24.996 4.687 -7.603 1.00 5.93 ? 342 SER B C 1 ATOM 2124 O O . SER A 1 286 ? 25.516 5.795 -7.468 1.00 6.37 ? 342 SER B O 1 ATOM 2125 C CB . SER A 1 286 ? 26.230 3.352 -9.304 1.00 13.50 ? 342 SER B CB 1 ATOM 2126 O OG . SER A 1 286 ? 26.258 2.931 -10.659 1.00 11.60 ? 342 SER B OG 1 ATOM 2127 N N . VAL A 1 287 ? 24.534 3.975 -6.575 1.00 12.91 ? 343 VAL B N 1 ATOM 2128 C CA . VAL A 1 287 ? 24.551 4.481 -5.195 1.00 2.00 ? 343 VAL B CA 1 ATOM 2129 C C . VAL A 1 287 ? 23.743 5.768 -5.026 1.00 13.64 ? 343 VAL B C 1 ATOM 2130 O O . VAL A 1 287 ? 24.273 6.872 -4.967 1.00 2.00 ? 343 VAL B O 1 ATOM 2131 C CB . VAL A 1 287 ? 25.972 4.620 -4.627 1.00 2.00 ? 343 VAL B CB 1 ATOM 2132 C CG1 . VAL A 1 287 ? 25.917 4.731 -3.142 1.00 2.00 ? 343 VAL B CG1 1 ATOM 2133 C CG2 . VAL A 1 287 ? 26.805 3.409 -5.020 1.00 2.00 ? 343 VAL B CG2 1 ATOM 2134 N N . ASN A 1 288 ? 22.434 5.587 -5.042 1.00 2.00 ? 344 ASN B N 1 ATOM 2135 C CA . ASN A 1 288 ? 21.472 6.622 -4.745 1.00 2.00 ? 344 ASN B CA 1 ATOM 2136 C C . ASN A 1 288 ? 20.256 5.924 -4.150 1.00 14.11 ? 344 ASN B C 1 ATOM 2137 O O . ASN A 1 288 ? 20.279 4.717 -3.928 1.00 11.73 ? 344 ASN B O 1 ATOM 2138 C CB . ASN A 1 288 ? 21.072 7.385 -6.005 1.00 2.00 ? 344 ASN B CB 1 ATOM 2139 C CG . ASN A 1 288 ? 22.170 8.302 -6.509 1.00 5.24 ? 344 ASN B CG 1 ATOM 2140 O OD1 . ASN A 1 288 ? 22.361 9.397 -5.987 1.00 2.00 ? 344 ASN B OD1 1 ATOM 2141 N ND2 . ASN A 1 288 ? 22.884 7.867 -7.546 1.00 8.28 ? 344 ASN B ND2 1 ATOM 2142 N N . GLN A 1 289 ? 19.216 6.691 -3.848 1.00 16.18 ? 345 GLN B N 1 ATOM 2143 C CA . GLN A 1 289 ? 17.971 6.145 -3.308 1.00 18.95 ? 345 GLN B CA 1 ATOM 2144 C C . GLN A 1 289 ? 16.850 5.963 -4.329 1.00 16.57 ? 345 GLN B C 1 ATOM 2145 O O . GLN A 1 289 ? 15.706 5.724 -3.947 1.00 21.32 ? 345 GLN B O 1 ATOM 2146 C CB . GLN A 1 289 ? 17.508 6.919 -2.076 1.00 26.13 ? 345 GLN B CB 1 ATOM 2147 C CG . GLN A 1 289 ? 18.264 6.537 -0.811 1.00 23.27 ? 345 GLN B CG 1 ATOM 2148 C CD . GLN A 1 289 ? 18.330 7.685 0.154 1.00 30.96 ? 345 GLN B CD 1 ATOM 2149 O OE1 . GLN A 1 289 ? 17.297 8.171 0.623 1.00 38.58 ? 345 GLN B OE1 1 ATOM 2150 N NE2 . GLN A 1 289 ? 19.545 8.155 0.436 1.00 28.19 ? 345 GLN B NE2 1 ATOM 2151 N N . ILE A 1 290 ? 17.188 6.135 -5.607 1.00 13.33 ? 346 ILE B N 1 ATOM 2152 C CA . ILE A 1 290 ? 16.246 6.110 -6.733 1.00 9.17 ? 346 ILE B CA 1 ATOM 2153 C C . ILE A 1 290 ? 15.303 4.898 -6.731 1.00 14.09 ? 346 ILE B C 1 ATOM 2154 O O . ILE A 1 290 ? 15.723 3.763 -6.500 1.00 15.55 ? 346 ILE B O 1 ATOM 2155 C CB . ILE A 1 290 ? 17.025 6.168 -8.079 1.00 2.00 ? 346 ILE B CB 1 ATOM 2156 C CG1 . ILE A 1 290 ? 17.781 7.488 -8.192 1.00 2.00 ? 346 ILE B CG1 1 ATOM 2157 C CG2 . ILE A 1 290 ? 16.099 6.024 -9.283 1.00 4.22 ? 346 ILE B CG2 1 ATOM 2158 C CD1 . ILE A 1 290 ? 18.451 7.697 -9.519 1.00 5.42 ? 346 ILE B CD1 1 ATOM 2159 N N . SER A 1 291 ? 14.021 5.159 -6.982 1.00 11.37 ? 347 SER B N 1 ATOM 2160 C CA . SER A 1 291 ? 12.993 4.123 -6.989 1.00 12.29 ? 347 SER B CA 1 ATOM 2161 C C . SER A 1 291 ? 12.268 4.072 -8.336 1.00 19.45 ? 347 SER B C 1 ATOM 2162 O O . SER A 1 291 ? 12.653 4.747 -9.288 1.00 37.74 ? 347 SER B O 1 ATOM 2163 C CB . SER A 1 291 ? 11.986 4.377 -5.874 1.00 8.93 ? 347 SER B CB 1 ATOM 2164 O OG . SER A 1 291 ? 11.442 5.681 -5.992 1.00 12.71 ? 347 SER B OG 1 ATOM 2165 N N . GLY A 1 292 ? 11.222 3.258 -8.414 1.00 2.04 ? 348 GLY B N 1 ATOM 2166 C CA . GLY A 1 292 ? 10.448 3.110 -9.628 1.00 2.00 ? 348 GLY B CA 1 ATOM 2167 C C . GLY A 1 292 ? 10.876 1.865 -10.367 1.00 14.32 ? 348 GLY B C 1 ATOM 2168 O O . GLY A 1 292 ? 11.798 1.164 -9.939 1.00 8.03 ? 348 GLY B O 1 ATOM 2169 N N . THR A 1 293 ? 10.157 1.554 -11.443 1.00 18.31 ? 349 THR B N 1 ATOM 2170 C CA . THR A 1 293 ? 10.592 0.574 -12.446 1.00 14.81 ? 349 THR B CA 1 ATOM 2171 C C . THR A 1 293 ? 11.537 1.216 -13.471 1.00 13.81 ? 349 THR B C 1 ATOM 2172 O O . THR A 1 293 ? 11.517 2.429 -13.651 1.00 19.80 ? 349 THR B O 1 ATOM 2173 C CB . THR A 1 293 ? 9.385 -0.061 -13.158 1.00 11.08 ? 349 THR B CB 1 ATOM 2174 O OG1 . THR A 1 293 ? 8.471 0.967 -13.539 1.00 18.74 ? 349 THR B OG1 1 ATOM 2175 C CG2 . THR A 1 293 ? 8.645 -1.011 -12.238 1.00 6.02 ? 349 THR B CG2 1 ATOM 2176 N N . ILE A 1 294 ? 12.382 0.424 -14.125 1.00 17.15 ? 350 ILE B N 1 ATOM 2177 C CA . ILE A 1 294 ? 13.169 0.953 -15.243 1.00 12.49 ? 350 ILE B CA 1 ATOM 2178 C C . ILE A 1 294 ? 12.200 1.284 -16.371 1.00 15.12 ? 350 ILE B C 1 ATOM 2179 O O . ILE A 1 294 ? 11.470 0.408 -16.838 1.00 22.32 ? 350 ILE B O 1 ATOM 2180 C CB . ILE A 1 294 ? 14.215 -0.055 -15.766 1.00 6.32 ? 350 ILE B CB 1 ATOM 2181 C CG1 . ILE A 1 294 ? 15.125 -0.529 -14.638 1.00 5.27 ? 350 ILE B CG1 1 ATOM 2182 C CG2 . ILE A 1 294 ? 15.058 0.575 -16.865 1.00 11.01 ? 350 ILE B CG2 1 ATOM 2183 C CD1 . ILE A 1 294 ? 15.935 -1.715 -14.995 1.00 2.00 ? 350 ILE B CD1 1 ATOM 2184 N N . PRO A 1 295 ? 12.172 2.556 -16.802 1.00 10.26 ? 351 PRO B N 1 ATOM 2185 C CA . PRO A 1 295 ? 11.200 3.010 -17.809 1.00 7.45 ? 351 PRO B CA 1 ATOM 2186 C C . PRO A 1 295 ? 11.468 2.441 -19.210 1.00 9.41 ? 351 PRO B C 1 ATOM 2187 O O . PRO A 1 295 ? 12.612 2.428 -19.671 1.00 12.46 ? 351 PRO B O 1 ATOM 2188 C CB . PRO A 1 295 ? 11.352 4.531 -17.780 1.00 4.44 ? 351 PRO B CB 1 ATOM 2189 C CG . PRO A 1 295 ? 12.740 4.767 -17.246 1.00 2.00 ? 351 PRO B CG 1 ATOM 2190 C CD . PRO A 1 295 ? 13.082 3.627 -16.361 1.00 5.91 ? 351 PRO B CD 1 ATOM 2191 N N . GLU A 1 296 ? 10.415 1.973 -19.874 1.00 14.41 ? 352 GLU B N 1 ATOM 2192 C CA . GLU A 1 296 ? 10.556 1.361 -21.197 1.00 15.09 ? 352 GLU B CA 1 ATOM 2193 C C . GLU A 1 296 ? 11.178 2.328 -22.190 1.00 15.96 ? 352 GLU B C 1 ATOM 2194 O O . GLU A 1 296 ? 11.924 1.920 -23.077 1.00 16.85 ? 352 GLU B O 1 ATOM 2195 C CB . GLU A 1 296 ? 9.208 0.891 -21.740 1.00 16.53 ? 352 GLU B CB 1 ATOM 2196 C CG . GLU A 1 296 ? 8.466 -0.089 -20.851 1.00 26.47 ? 352 GLU B CG 1 ATOM 2197 C CD . GLU A 1 296 ? 9.110 -1.461 -20.807 1.00 33.09 ? 352 GLU B CD 1 ATOM 2198 O OE1 . GLU A 1 296 ? 9.743 -1.791 -19.783 1.00 44.80 ? 352 GLU B OE1 1 ATOM 2199 O OE2 . GLU A 1 296 ? 8.966 -2.215 -21.788 1.00 27.41 ? 352 GLU B OE2 1 ATOM 2200 N N . GLU A 1 297 ? 10.887 3.613 -22.039 1.00 2.00 ? 353 GLU B N 1 ATOM 2201 C CA . GLU A 1 297 ? 11.389 4.580 -23.001 1.00 2.00 ? 353 GLU B CA 1 ATOM 2202 C C . GLU A 1 297 ? 12.899 4.719 -23.017 1.00 10.30 ? 353 GLU B C 1 ATOM 2203 O O . GLU A 1 297 ? 13.447 5.209 -23.988 1.00 13.83 ? 353 GLU B O 1 ATOM 2204 C CB . GLU A 1 297 ? 10.710 5.950 -22.873 1.00 6.68 ? 353 GLU B CB 1 ATOM 2205 C CG . GLU A 1 297 ? 10.133 6.280 -21.531 1.00 11.20 ? 353 GLU B CG 1 ATOM 2206 C CD . GLU A 1 297 ? 8.816 5.577 -21.241 1.00 13.35 ? 353 GLU B CD 1 ATOM 2207 O OE1 . GLU A 1 297 ? 7.744 6.167 -21.510 1.00 18.18 ? 353 GLU B OE1 1 ATOM 2208 O OE2 . GLU A 1 297 ? 8.865 4.442 -20.715 1.00 11.82 ? 353 GLU B OE2 1 ATOM 2209 N N . LEU A 1 298 ? 13.576 4.273 -21.957 1.00 17.58 ? 354 LEU B N 1 ATOM 2210 C CA . LEU A 1 298 ? 15.045 4.325 -21.916 1.00 16.02 ? 354 LEU B CA 1 ATOM 2211 C C . LEU A 1 298 ? 15.649 3.383 -22.963 1.00 21.15 ? 354 LEU B C 1 ATOM 2212 O O . LEU A 1 298 ? 16.793 3.541 -23.375 1.00 11.12 ? 354 LEU B O 1 ATOM 2213 C CB . LEU A 1 298 ? 15.585 4.003 -20.517 1.00 13.02 ? 354 LEU B CB 1 ATOM 2214 C CG . LEU A 1 298 ? 17.067 4.335 -20.238 1.00 14.95 ? 354 LEU B CG 1 ATOM 2215 C CD1 . LEU A 1 298 ? 17.305 5.828 -20.043 1.00 14.06 ? 354 LEU B CD1 1 ATOM 2216 C CD2 . LEU A 1 298 ? 17.599 3.573 -19.046 1.00 10.67 ? 354 LEU B CD2 1 ATOM 2217 N N . THR A 1 299 ? 14.857 2.415 -23.410 1.00 29.67 ? 355 THR B N 1 ATOM 2218 C CA . THR A 1 299 ? 15.283 1.506 -24.468 1.00 20.71 ? 355 THR B CA 1 ATOM 2219 C C . THR A 1 299 ? 15.285 2.160 -25.866 1.00 13.03 ? 355 THR B C 1 ATOM 2220 O O . THR A 1 299 ? 15.682 1.533 -26.837 1.00 16.51 ? 355 THR B O 1 ATOM 2221 C CB . THR A 1 299 ? 14.453 0.212 -24.471 1.00 15.30 ? 355 THR B CB 1 ATOM 2222 O OG1 . THR A 1 299 ? 13.119 0.499 -24.896 1.00 15.24 ? 355 THR B OG1 1 ATOM 2223 C CG2 . THR A 1 299 ? 14.416 -0.403 -23.075 1.00 6.89 ? 355 THR B CG2 1 ATOM 2224 N N . ASN A 1 300 ? 14.851 3.417 -25.954 1.00 5.35 ? 356 ASN B N 1 ATOM 2225 C CA . ASN A 1 300 ? 14.931 4.219 -27.181 1.00 2.00 ? 356 ASN B CA 1 ATOM 2226 C C . ASN A 1 300 ? 16.302 4.878 -27.347 1.00 18.01 ? 356 ASN B C 1 ATOM 2227 O O . ASN A 1 300 ? 16.528 5.693 -28.244 1.00 12.86 ? 356 ASN B O 1 ATOM 2228 C CB . ASN A 1 300 ? 13.881 5.319 -27.161 1.00 6.13 ? 356 ASN B CB 1 ATOM 2229 C CG . ASN A 1 300 ? 12.691 4.999 -28.017 1.00 19.58 ? 356 ASN B CG 1 ATOM 2230 O OD1 . ASN A 1 300 ? 12.473 3.849 -28.384 1.00 16.87 ? 356 ASN B OD1 1 ATOM 2231 N ND2 . ASN A 1 300 ? 11.910 6.021 -28.351 1.00 32.45 ? 356 ASN B ND2 1 ATOM 2232 N N . CYS A 1 301 ? 17.206 4.517 -26.451 1.00 29.88 ? 357 CYS B N 1 ATOM 2233 C CA . CYS A 1 301 ? 18.478 5.201 -26.220 1.00 29.22 ? 357 CYS B CA 1 ATOM 2234 C C . CYS A 1 301 ? 19.658 4.805 -27.096 1.00 28.23 ? 357 CYS B C 1 ATOM 2235 O O . CYS A 1 301 ? 20.798 4.886 -26.659 1.00 27.23 ? 357 CYS B O 1 ATOM 2236 C CB . CYS A 1 301 ? 18.840 5.291 -24.748 1.00 32.06 ? 357 CYS B CB 1 ATOM 2237 S SG . CYS A 1 301 ? 18.023 6.702 -23.989 1.00 19.20 ? 357 CYS B SG 1 ATOM 2238 N N . THR A 1 302 ? 19.367 4.382 -28.323 1.00 29.36 ? 358 THR B N 1 ATOM 2239 C CA . THR A 1 302 ? 20.193 3.529 -29.177 1.00 23.20 ? 358 THR B CA 1 ATOM 2240 C C . THR A 1 302 ? 21.715 3.570 -28.989 1.00 15.80 ? 358 THR B C 1 ATOM 2241 O O . THR A 1 302 ? 22.364 2.536 -29.081 1.00 16.42 ? 358 THR B O 1 ATOM 2242 C CB . THR A 1 302 ? 19.971 4.040 -30.622 1.00 23.89 ? 358 THR B CB 1 ATOM 2243 O OG1 . THR A 1 302 ? 18.620 3.800 -31.011 1.00 24.21 ? 358 THR B OG1 1 ATOM 2244 C CG2 . THR A 1 302 ? 20.913 3.397 -31.618 1.00 36.80 ? 358 THR B CG2 1 ATOM 2245 N N . LYS A 1 303 ? 22.291 4.731 -28.713 1.00 9.10 ? 359 LYS B N 1 ATOM 2246 C CA . LYS A 1 303 ? 23.743 4.830 -28.631 1.00 2.00 ? 359 LYS B CA 1 ATOM 2247 C C . LYS A 1 303 ? 24.354 4.437 -27.265 1.00 7.50 ? 359 LYS B C 1 ATOM 2248 O O . LYS A 1 303 ? 25.569 4.503 -27.083 1.00 12.61 ? 359 LYS B O 1 ATOM 2249 C CB . LYS A 1 303 ? 24.188 6.231 -29.076 1.00 2.00 ? 359 LYS B CB 1 ATOM 2250 C CG . LYS A 1 303 ? 23.717 6.587 -30.504 1.00 3.04 ? 359 LYS B CG 1 ATOM 2251 C CD . LYS A 1 303 ? 23.886 8.052 -30.867 1.00 9.16 ? 359 LYS B CD 1 ATOM 2252 C CE . LYS A 1 303 ? 25.265 8.338 -31.418 1.00 19.28 ? 359 LYS B CE 1 ATOM 2253 N NZ . LYS A 1 303 ? 25.283 9.618 -32.197 1.00 23.53 ? 359 LYS B NZ 1 ATOM 2254 N N . LEU A 1 304 ? 23.506 4.015 -26.326 1.00 4.55 ? 360 LEU B N 1 ATOM 2255 C CA . LEU A 1 304 ? 23.883 3.657 -24.949 1.00 2.00 ? 360 LEU B CA 1 ATOM 2256 C C . LEU A 1 304 ? 24.865 2.502 -24.859 1.00 2.00 ? 360 LEU B C 1 ATOM 2257 O O . LEU A 1 304 ? 24.563 1.394 -25.287 1.00 35.19 ? 360 LEU B O 1 ATOM 2258 C CB . LEU A 1 304 ? 22.619 3.205 -24.225 1.00 2.00 ? 360 LEU B CB 1 ATOM 2259 C CG . LEU A 1 304 ? 22.309 3.330 -22.740 1.00 14.53 ? 360 LEU B CG 1 ATOM 2260 C CD1 . LEU A 1 304 ? 22.150 4.780 -22.311 1.00 2.00 ? 360 LEU B CD1 1 ATOM 2261 C CD2 . LEU A 1 304 ? 21.036 2.550 -22.464 1.00 15.40 ? 360 LEU B CD2 1 ATOM 2262 N N . THR A 1 305 ? 26.006 2.743 -24.228 1.00 15.47 ? 361 THR B N 1 ATOM 2263 C CA . THR A 1 305 ? 27.022 1.716 -24.008 1.00 14.60 ? 361 THR B CA 1 ATOM 2264 C C . THR A 1 305 ? 27.007 1.258 -22.560 1.00 15.90 ? 361 THR B C 1 ATOM 2265 O O . THR A 1 305 ? 26.934 0.059 -22.286 1.00 13.95 ? 361 THR B O 1 ATOM 2266 C CB . THR A 1 305 ? 28.424 2.177 -24.394 1.00 14.79 ? 361 THR B CB 1 ATOM 2267 O OG1 . THR A 1 305 ? 28.894 3.122 -23.424 1.00 20.85 ? 361 THR B OG1 1 ATOM 2268 C CG2 . THR A 1 305 ? 28.398 2.802 -25.774 1.00 10.50 ? 361 THR B CG2 1 ATOM 2269 N N . HIS A 1 306 ? 27.171 2.211 -21.644 1.00 2.00 ? 362 HIS B N 1 ATOM 2270 C CA . HIS A 1 306 ? 27.114 1.921 -20.204 1.00 7.60 ? 362 HIS B CA 1 ATOM 2271 C C . HIS A 1 306 ? 25.808 2.375 -19.547 1.00 8.20 ? 362 HIS B C 1 ATOM 2272 O O . HIS A 1 306 ? 25.497 3.570 -19.516 1.00 2.00 ? 362 HIS B O 1 ATOM 2273 C CB . HIS A 1 306 ? 28.291 2.566 -19.453 1.00 2.00 ? 362 HIS B CB 1 ATOM 2274 C CG . HIS A 1 306 ? 29.639 2.147 -19.957 1.00 20.53 ? 362 HIS B CG 1 ATOM 2275 N ND1 . HIS A 1 306 ? 29.879 1.845 -21.274 1.00 24.31 ? 362 HIS B ND1 1 ATOM 2276 C CD2 . HIS A 1 306 ? 30.817 2.004 -19.310 1.00 29.01 ? 362 HIS B CD2 1 ATOM 2277 C CE1 . HIS A 1 306 ? 31.155 1.521 -21.425 1.00 34.39 ? 362 HIS B CE1 1 ATOM 2278 N NE2 . HIS A 1 306 ? 31.742 1.606 -20.247 1.00 35.70 ? 362 HIS B NE2 1 ATOM 2279 N N . LEU A 1 307 ? 25.054 1.418 -19.012 1.00 14.30 ? 363 LEU B N 1 ATOM 2280 C CA . LEU A 1 307 ? 23.962 1.727 -18.090 1.00 16.53 ? 363 LEU B CA 1 ATOM 2281 C C . LEU A 1 307 ? 24.316 1.183 -16.709 1.00 7.42 ? 363 LEU B C 1 ATOM 2282 O O . LEU A 1 307 ? 24.287 -0.030 -16.514 1.00 6.37 ? 363 LEU B O 1 ATOM 2283 C CB . LEU A 1 307 ? 22.656 1.088 -18.582 1.00 21.04 ? 363 LEU B CB 1 ATOM 2284 C CG . LEU A 1 307 ? 21.347 1.311 -17.810 1.00 23.01 ? 363 LEU B CG 1 ATOM 2285 C CD1 . LEU A 1 307 ? 20.958 2.790 -17.734 1.00 19.09 ? 363 LEU B CD1 1 ATOM 2286 C CD2 . LEU A 1 307 ? 20.235 0.506 -18.453 1.00 2.00 ? 363 LEU B CD2 1 ATOM 2287 N N . GLU A 1 308 ? 24.658 2.068 -15.764 1.00 10.42 ? 364 GLU B N 1 ATOM 2288 C CA . GLU A 1 308 ? 24.909 1.657 -14.380 1.00 8.17 ? 364 GLU B CA 1 ATOM 2289 C C . GLU A 1 308 ? 23.842 2.230 -13.461 1.00 8.00 ? 364 GLU B C 1 ATOM 2290 O O . GLU A 1 308 ? 23.897 3.398 -13.080 1.00 4.98 ? 364 GLU B O 1 ATOM 2291 C CB . GLU A 1 308 ? 26.239 2.227 -13.899 1.00 16.15 ? 364 GLU B CB 1 ATOM 2292 C CG . GLU A 1 308 ? 27.417 1.306 -13.999 1.00 19.08 ? 364 GLU B CG 1 ATOM 2293 C CD . GLU A 1 308 ? 27.968 1.278 -15.378 1.00 26.99 ? 364 GLU B CD 1 ATOM 2294 O OE1 . GLU A 1 308 ? 28.976 1.971 -15.619 1.00 27.66 ? 364 GLU B OE1 1 ATOM 2295 O OE2 . GLU A 1 308 ? 27.381 0.574 -16.224 1.00 36.68 ? 364 GLU B OE2 1 ATOM 2296 N N . ILE A 1 309 ? 22.871 1.395 -13.119 1.00 9.91 ? 365 ILE B N 1 ATOM 2297 C CA . ILE A 1 309 ? 21.784 1.756 -12.221 1.00 2.00 ? 365 ILE B CA 1 ATOM 2298 C C . ILE A 1 309 ? 21.848 1.078 -10.851 1.00 11.69 ? 365 ILE B C 1 ATOM 2299 O O . ILE A 1 309 ? 20.889 1.111 -10.082 1.00 13.61 ? 365 ILE B O 1 ATOM 2300 C CB . ILE A 1 309 ? 20.401 1.705 -12.908 1.00 16.08 ? 365 ILE B CB 1 ATOM 2301 C CG1 . ILE A 1 309 ? 20.185 0.375 -13.618 1.00 20.09 ? 365 ILE B CG1 1 ATOM 2302 C CG2 . ILE A 1 309 ? 20.291 2.815 -13.935 1.00 2.00 ? 365 ILE B CG2 1 ATOM 2303 C CD1 . ILE A 1 309 ? 18.842 0.278 -14.284 1.00 22.87 ? 365 ILE B CD1 1 ATOM 2304 N N . ASP A 1 310 ? 22.961 0.407 -10.584 1.00 13.99 ? 366 ASP B N 1 ATOM 2305 C CA . ASP A 1 310 ? 23.117 -0.427 -9.389 1.00 14.78 ? 366 ASP B CA 1 ATOM 2306 C C . ASP A 1 310 ? 23.072 0.360 -8.087 1.00 9.49 ? 366 ASP B C 1 ATOM 2307 O O . ASP A 1 310 ? 23.215 1.575 -8.095 1.00 4.45 ? 366 ASP B O 1 ATOM 2308 C CB . ASP A 1 310 ? 24.442 -1.174 -9.447 1.00 15.50 ? 366 ASP B CB 1 ATOM 2309 C CG . ASP A 1 310 ? 25.618 -0.241 -9.428 1.00 22.78 ? 366 ASP B CG 1 ATOM 2310 O OD1 . ASP A 1 310 ? 25.970 0.274 -10.518 1.00 18.71 ? 366 ASP B OD1 1 ATOM 2311 O OD2 . ASP A 1 310 ? 26.171 -0.012 -8.324 1.00 24.58 ? 366 ASP B OD2 1 ATOM 2312 N N . ASN A 1 311 ? 22.849 -0.356 -6.982 1.00 2.00 ? 367 ASN B N 1 ATOM 2313 C CA . ASN A 1 311 ? 22.765 0.219 -5.639 1.00 2.00 ? 367 ASN B CA 1 ATOM 2314 C C . ASN A 1 311 ? 21.728 1.322 -5.506 1.00 9.39 ? 367 ASN B C 1 ATOM 2315 O O . ASN A 1 311 ? 22.047 2.498 -5.315 1.00 2.00 ? 367 ASN B O 1 ATOM 2316 C CB . ASN A 1 311 ? 24.134 0.632 -5.103 1.00 2.00 ? 367 ASN B CB 1 ATOM 2317 C CG . ASN A 1 311 ? 24.914 -0.556 -4.561 1.00 15.23 ? 367 ASN B CG 1 ATOM 2318 O OD1 . ASN A 1 311 ? 24.722 -0.974 -3.418 1.00 20.38 ? 367 ASN B OD1 1 ATOM 2319 N ND2 . ASN A 1 311 ? 25.774 -1.129 -5.394 1.00 5.03 ? 367 ASN B ND2 1 ATOM 2320 N N . ASN A 1 312 ? 20.475 0.896 -5.612 1.00 7.81 ? 368 ASN B N 1 ATOM 2321 C CA . ASN A 1 312 ? 19.317 1.770 -5.561 1.00 3.74 ? 368 ASN B CA 1 ATOM 2322 C C . ASN A 1 312 ? 18.107 0.985 -5.041 1.00 9.80 ? 368 ASN B C 1 ATOM 2323 O O . ASN A 1 312 ? 18.239 -0.132 -4.531 1.00 12.23 ? 368 ASN B O 1 ATOM 2324 C CB . ASN A 1 312 ? 19.010 2.349 -6.947 1.00 2.00 ? 368 ASN B CB 1 ATOM 2325 C CG . ASN A 1 312 ? 19.872 3.552 -7.295 1.00 13.09 ? 368 ASN B CG 1 ATOM 2326 O OD1 . ASN A 1 312 ? 19.548 4.676 -6.931 1.00 13.22 ? 368 ASN B OD1 1 ATOM 2327 N ND2 . ASN A 1 312 ? 20.955 3.325 -8.040 1.00 6.87 ? 368 ASN B ND2 1 ATOM 2328 N N . LEU A 1 313 ? 16.943 1.617 -5.123 1.00 4.26 ? 369 LEU B N 1 ATOM 2329 C CA . LEU A 1 313 ? 15.661 1.010 -4.804 1.00 2.00 ? 369 LEU B CA 1 ATOM 2330 C C . LEU A 1 313 ? 14.800 0.547 -5.998 1.00 11.59 ? 369 LEU B C 1 ATOM 2331 O O . LEU A 1 313 ? 13.621 0.249 -5.818 1.00 12.51 ? 369 LEU B O 1 ATOM 2332 C CB . LEU A 1 313 ? 14.867 1.920 -3.858 1.00 29.96 ? 369 LEU B CB 1 ATOM 2333 C CG . LEU A 1 313 ? 15.579 2.402 -2.578 1.00 22.62 ? 369 LEU B CG 1 ATOM 2334 C CD1 . LEU A 1 313 ? 14.720 3.422 -1.886 1.00 2.00 ? 369 LEU B CD1 1 ATOM 2335 C CD2 . LEU A 1 313 ? 15.923 1.269 -1.637 1.00 2.00 ? 369 LEU B CD2 1 ATOM 2336 N N . ILE A 1 314 ? 15.343 0.565 -7.213 1.00 11.05 ? 370 ILE B N 1 ATOM 2337 C CA . ILE A 1 314 ? 14.556 0.272 -8.416 1.00 8.09 ? 370 ILE B CA 1 ATOM 2338 C C . ILE A 1 314 ? 13.782 -1.029 -8.242 1.00 9.09 ? 370 ILE B C 1 ATOM 2339 O O . ILE A 1 314 ? 14.327 -2.006 -7.725 1.00 4.19 ? 370 ILE B O 1 ATOM 2340 C CB . ILE A 1 314 ? 15.443 0.094 -9.687 1.00 30.30 ? 370 ILE B CB 1 ATOM 2341 C CG1 . ILE A 1 314 ? 16.472 1.210 -9.828 1.00 2.00 ? 370 ILE B CG1 1 ATOM 2342 C CG2 . ILE A 1 314 ? 14.579 -0.001 -10.940 1.00 2.00 ? 370 ILE B CG2 1 ATOM 2343 C CD1 . ILE A 1 314 ? 15.884 2.565 -9.678 1.00 2.34 ? 370 ILE B CD1 1 ATOM 2344 N N . THR A 1 315 ? 12.515 -1.035 -8.661 1.00 6.14 ? 371 THR B N 1 ATOM 2345 C CA . THR A 1 315 ? 11.718 -2.256 -8.631 1.00 2.00 ? 371 THR B CA 1 ATOM 2346 C C . THR A 1 315 ? 11.254 -2.653 -10.012 1.00 4.30 ? 371 THR B C 1 ATOM 2347 O O . THR A 1 315 ? 11.532 -1.968 -10.978 1.00 18.35 ? 371 THR B O 1 ATOM 2348 C CB . THR A 1 315 ? 10.500 -2.154 -7.673 1.00 16.97 ? 371 THR B CB 1 ATOM 2349 O OG1 . THR A 1 315 ? 9.633 -1.095 -8.094 1.00 19.91 ? 371 THR B OG1 1 ATOM 2350 C CG2 . THR A 1 315 ? 10.961 -1.879 -6.261 1.00 2.00 ? 371 THR B CG2 1 ATOM 2351 N N . GLY A 1 316 ? 10.542 -3.766 -10.104 1.00 2.00 ? 372 GLY B N 1 ATOM 2352 C CA . GLY A 1 316 ? 9.955 -4.167 -11.364 1.00 2.00 ? 372 GLY B CA 1 ATOM 2353 C C . GLY A 1 316 ? 10.722 -5.259 -12.065 1.00 24.11 ? 372 GLY B C 1 ATOM 2354 O O . GLY A 1 316 ? 11.558 -5.929 -11.465 1.00 24.80 ? 372 GLY B O 1 ATOM 2355 N N . GLU A 1 317 ? 10.409 -5.444 -13.345 1.00 24.78 ? 373 GLU B N 1 ATOM 2356 C CA . GLU A 1 317 ? 11.096 -6.404 -14.197 1.00 18.46 ? 373 GLU B CA 1 ATOM 2357 C C . GLU A 1 317 ? 12.042 -5.651 -15.113 1.00 11.13 ? 373 GLU B C 1 ATOM 2358 O O . GLU A 1 317 ? 11.829 -4.473 -15.410 1.00 4.33 ? 373 GLU B O 1 ATOM 2359 C CB . GLU A 1 317 ? 10.108 -7.208 -15.040 1.00 12.90 ? 373 GLU B CB 1 ATOM 2360 C CG . GLU A 1 317 ? 8.943 -7.761 -14.268 1.00 16.38 ? 373 GLU B CG 1 ATOM 2361 C CD . GLU A 1 317 ? 8.341 -8.982 -14.917 1.00 26.33 ? 373 GLU B CD 1 ATOM 2362 O OE1 . GLU A 1 317 ? 7.144 -9.253 -14.681 1.00 33.38 ? 373 GLU B OE1 1 ATOM 2363 O OE2 . GLU A 1 317 ? 9.071 -9.681 -15.648 1.00 29.82 ? 373 GLU B OE2 1 ATOM 2364 N N . ILE A 1 318 ? 13.122 -6.316 -15.505 1.00 8.88 ? 374 ILE B N 1 ATOM 2365 C CA . ILE A 1 318 ? 14.011 -5.778 -16.518 1.00 3.98 ? 374 ILE B CA 1 ATOM 2366 C C . ILE A 1 318 ? 13.190 -5.668 -17.793 1.00 8.68 ? 374 ILE B C 1 ATOM 2367 O O . ILE A 1 318 ? 12.538 -6.633 -18.193 1.00 18.65 ? 374 ILE B O 1 ATOM 2368 C CB . ILE A 1 318 ? 15.229 -6.705 -16.693 1.00 7.00 ? 374 ILE B CB 1 ATOM 2369 C CG1 . ILE A 1 318 ? 16.088 -6.682 -15.418 1.00 2.26 ? 374 ILE B CG1 1 ATOM 2370 C CG2 . ILE A 1 318 ? 16.056 -6.296 -17.889 1.00 2.00 ? 374 ILE B CG2 1 ATOM 2371 C CD1 . ILE A 1 318 ? 16.942 -7.922 -15.200 1.00 2.00 ? 374 ILE B CD1 1 ATOM 2372 N N . PRO A 1 319 ? 13.173 -4.478 -18.412 1.00 8.50 ? 375 PRO B N 1 ATOM 2373 C CA . PRO A 1 319 ? 12.402 -4.282 -19.652 1.00 11.90 ? 375 PRO B CA 1 ATOM 2374 C C . PRO A 1 319 ? 12.893 -5.211 -20.763 1.00 19.93 ? 375 PRO B C 1 ATOM 2375 O O . PRO A 1 319 ? 14.099 -5.308 -20.998 1.00 18.51 ? 375 PRO B O 1 ATOM 2376 C CB . PRO A 1 319 ? 12.683 -2.823 -20.028 1.00 4.73 ? 375 PRO B CB 1 ATOM 2377 C CG . PRO A 1 319 ? 13.204 -2.179 -18.758 1.00 9.36 ? 375 PRO B CG 1 ATOM 2378 C CD . PRO A 1 319 ? 13.932 -3.276 -18.030 1.00 8.55 ? 375 PRO B CD 1 ATOM 2379 N N . SER A 1 320 ? 11.965 -5.894 -21.428 1.00 24.93 ? 376 SER B N 1 ATOM 2380 C CA . SER A 1 320 ? 12.306 -6.837 -22.489 1.00 14.86 ? 376 SER B CA 1 ATOM 2381 C C . SER A 1 320 ? 12.818 -6.118 -23.725 1.00 7.41 ? 376 SER B C 1 ATOM 2382 O O . SER A 1 320 ? 13.623 -6.663 -24.472 1.00 13.63 ? 376 SER B O 1 ATOM 2383 C CB . SER A 1 320 ? 11.089 -7.665 -22.840 1.00 22.26 ? 376 SER B CB 1 ATOM 2384 O OG . SER A 1 320 ? 9.924 -6.888 -22.609 1.00 38.98 ? 376 SER B OG 1 ATOM 2385 N N . LEU A 1 321 ? 12.399 -4.874 -23.918 1.00 4.28 ? 377 LEU B N 1 ATOM 2386 C CA . LEU A 1 321 ? 12.850 -4.098 -25.077 1.00 9.65 ? 377 LEU B CA 1 ATOM 2387 C C . LEU A 1 321 ? 14.327 -3.727 -25.007 1.00 15.88 ? 377 LEU B C 1 ATOM 2388 O O . LEU A 1 321 ? 14.865 -3.108 -25.926 1.00 21.81 ? 377 LEU B O 1 ATOM 2389 C CB . LEU A 1 321 ? 11.978 -2.861 -25.316 1.00 15.89 ? 377 LEU B CB 1 ATOM 2390 C CG . LEU A 1 321 ? 10.730 -3.184 -26.147 1.00 21.45 ? 377 LEU B CG 1 ATOM 2391 C CD1 . LEU A 1 321 ? 9.970 -1.941 -26.539 1.00 2.00 ? 377 LEU B CD1 1 ATOM 2392 C CD2 . LEU A 1 321 ? 11.139 -3.961 -27.367 1.00 2.00 ? 377 LEU B CD2 1 ATOM 2393 N N . MET A 1 322 ? 14.974 -4.126 -23.915 1.00 14.30 ? 378 MET B N 1 ATOM 2394 C CA . MET A 1 322 ? 16.403 -3.914 -23.682 1.00 18.82 ? 378 MET B CA 1 ATOM 2395 C C . MET A 1 322 ? 17.237 -4.392 -24.871 1.00 24.92 ? 378 MET B C 1 ATOM 2396 O O . MET A 1 322 ? 18.391 -3.995 -25.042 1.00 23.74 ? 378 MET B O 1 ATOM 2397 C CB . MET A 1 322 ? 16.818 -4.704 -22.445 1.00 25.89 ? 378 MET B CB 1 ATOM 2398 C CG . MET A 1 322 ? 18.004 -4.143 -21.723 1.00 36.35 ? 378 MET B CG 1 ATOM 2399 S SD . MET A 1 322 ? 17.558 -3.052 -20.360 1.00 18.45 ? 378 MET B SD 1 ATOM 2400 C CE . MET A 1 322 ? 19.211 -2.520 -19.929 1.00 31.67 ? 378 MET B CE 1 ATOM 2401 N N . SER A 1 323 ? 16.643 -5.280 -25.664 1.00 26.32 ? 379 SER B N 1 ATOM 2402 C CA . SER A 1 323 ? 17.190 -5.723 -26.935 1.00 13.55 ? 379 SER B CA 1 ATOM 2403 C C . SER A 1 323 ? 17.344 -4.581 -27.931 1.00 9.52 ? 379 SER B C 1 ATOM 2404 O O . SER A 1 323 ? 18.095 -4.690 -28.896 1.00 13.95 ? 379 SER B O 1 ATOM 2405 C CB . SER A 1 323 ? 16.253 -6.755 -27.539 1.00 12.05 ? 379 SER B CB 1 ATOM 2406 O OG . SER A 1 323 ? 14.912 -6.317 -27.427 1.00 15.44 ? 379 SER B OG 1 ATOM 2407 N N . ASN A 1 324 ? 16.622 -3.492 -27.717 1.00 4.58 ? 380 ASN B N 1 ATOM 2408 C CA . ASN A 1 324 ? 16.729 -2.352 -28.619 1.00 10.76 ? 380 ASN B CA 1 ATOM 2409 C C . ASN A 1 324 ? 18.055 -1.608 -28.496 1.00 19.22 ? 380 ASN B C 1 ATOM 2410 O O . ASN A 1 324 ? 18.371 -0.754 -29.315 1.00 26.45 ? 380 ASN B O 1 ATOM 2411 C CB . ASN A 1 324 ? 15.573 -1.382 -28.398 1.00 15.22 ? 380 ASN B CB 1 ATOM 2412 C CG . ASN A 1 324 ? 14.819 -1.087 -29.668 1.00 26.00 ? 380 ASN B CG 1 ATOM 2413 O OD1 . ASN A 1 324 ? 14.880 0.028 -30.193 1.00 34.09 ? 380 ASN B OD1 1 ATOM 2414 N ND2 . ASN A 1 324 ? 14.105 -2.090 -30.183 1.00 28.14 ? 380 ASN B ND2 1 ATOM 2415 N N . LEU A 1 325 ? 18.836 -1.910 -27.470 1.00 17.65 ? 381 LEU B N 1 ATOM 2416 C CA . LEU A 1 325 ? 20.093 -1.209 -27.323 1.00 12.17 ? 381 LEU B CA 1 ATOM 2417 C C . LEU A 1 325 ? 21.182 -2.147 -27.799 1.00 21.16 ? 381 LEU B C 1 ATOM 2418 O O . LEU A 1 325 ? 21.570 -3.073 -27.090 1.00 29.74 ? 381 LEU B O 1 ATOM 2419 C CB . LEU A 1 325 ? 20.303 -0.862 -25.859 1.00 4.54 ? 381 LEU B CB 1 ATOM 2420 C CG . LEU A 1 325 ? 19.167 -0.158 -25.113 1.00 4.07 ? 381 LEU B CG 1 ATOM 2421 C CD1 . LEU A 1 325 ? 19.276 -0.454 -23.593 1.00 2.00 ? 381 LEU B CD1 1 ATOM 2422 C CD2 . LEU A 1 325 ? 19.186 1.349 -25.402 1.00 2.00 ? 381 LEU B CD2 1 ATOM 2423 N N . ARG A 1 326 ? 21.696 -1.897 -28.996 1.00 20.88 ? 382 ARG B N 1 ATOM 2424 C CA . ARG A 1 326 ? 22.587 -2.862 -29.616 1.00 16.54 ? 382 ARG B CA 1 ATOM 2425 C C . ARG A 1 326 ? 24.035 -2.529 -29.348 1.00 23.75 ? 382 ARG B C 1 ATOM 2426 O O . ARG A 1 326 ? 24.925 -3.333 -29.600 1.00 33.33 ? 382 ARG B O 1 ATOM 2427 C CB . ARG A 1 326 ? 22.313 -2.954 -31.110 1.00 14.13 ? 382 ARG B CB 1 ATOM 2428 C CG . ARG A 1 326 ? 20.855 -3.235 -31.452 1.00 20.73 ? 382 ARG B CG 1 ATOM 2429 C CD . ARG A 1 326 ? 20.387 -4.594 -30.935 1.00 29.52 ? 382 ARG B CD 1 ATOM 2430 N NE . ARG A 1 326 ? 18.993 -4.851 -31.298 1.00 40.00 ? 382 ARG B NE 1 ATOM 2431 C CZ . ARG A 1 326 ? 18.582 -5.863 -32.060 1.00 46.01 ? 382 ARG B CZ 1 ATOM 2432 N NH1 . ARG A 1 326 ? 19.457 -6.742 -32.536 1.00 45.78 ? 382 ARG B NH1 1 ATOM 2433 N NH2 . ARG A 1 326 ? 17.292 -6.004 -32.335 1.00 43.26 ? 382 ARG B NH2 1 ATOM 2434 N N . SER A 1 327 ? 24.267 -1.338 -28.821 1.00 21.38 ? 383 SER B N 1 ATOM 2435 C CA . SER A 1 327 ? 25.619 -0.915 -28.491 1.00 18.10 ? 383 SER B CA 1 ATOM 2436 C C . SER A 1 327 ? 25.989 -1.069 -27.006 1.00 15.16 ? 383 SER B C 1 ATOM 2437 O O . SER A 1 327 ? 27.110 -0.749 -26.619 1.00 2.53 ? 383 SER B O 1 ATOM 2438 C CB . SER A 1 327 ? 25.847 0.518 -28.973 1.00 15.22 ? 383 SER B CB 1 ATOM 2439 O OG . SER A 1 327 ? 25.591 0.621 -30.368 1.00 7.79 ? 383 SER B OG 1 ATOM 2440 N N . LEU A 1 328 ? 25.047 -1.546 -26.190 1.00 2.11 ? 384 LEU B N 1 ATOM 2441 C CA . LEU A 1 328 ? 25.262 -1.735 -24.765 1.00 2.08 ? 384 LEU B CA 1 ATOM 2442 C C . LEU A 1 328 ? 26.425 -2.689 -24.499 1.00 18.60 ? 384 LEU B C 1 ATOM 2443 O O . LEU A 1 328 ? 26.490 -3.790 -25.042 1.00 17.67 ? 384 LEU B O 1 ATOM 2444 C CB . LEU A 1 328 ? 23.980 -2.246 -24.087 1.00 2.00 ? 384 LEU B CB 1 ATOM 2445 C CG . LEU A 1 328 ? 23.856 -2.262 -22.540 1.00 8.85 ? 384 LEU B CG 1 ATOM 2446 C CD1 . LEU A 1 328 ? 23.778 -0.875 -21.947 1.00 2.00 ? 384 LEU B CD1 1 ATOM 2447 C CD2 . LEU A 1 328 ? 22.663 -3.088 -22.072 1.00 2.00 ? 384 LEU B CD2 1 ATOM 2448 N N . THR A 1 329 ? 27.351 -2.246 -23.658 1.00 21.22 ? 385 THR B N 1 ATOM 2449 C CA . THR A 1 329 ? 28.505 -3.049 -23.263 1.00 16.65 ? 385 THR B CA 1 ATOM 2450 C C . THR A 1 329 ? 28.389 -3.490 -21.808 1.00 8.67 ? 385 THR B C 1 ATOM 2451 O O . THR A 1 329 ? 28.455 -4.675 -21.489 1.00 5.92 ? 385 THR B O 1 ATOM 2452 C CB . THR A 1 329 ? 29.848 -2.338 -23.536 1.00 11.51 ? 385 THR B CB 1 ATOM 2453 O OG1 . THR A 1 329 ? 29.752 -0.952 -23.185 1.00 10.01 ? 385 THR B OG1 1 ATOM 2454 C CG2 . THR A 1 329 ? 30.182 -2.452 -25.000 1.00 4.53 ? 385 THR B CG2 1 ATOM 2455 N N . MET A 1 330 ? 28.277 -2.511 -20.930 1.00 8.34 ? 386 MET B N 1 ATOM 2456 C CA . MET A 1 330 ? 28.166 -2.751 -19.502 1.00 12.31 ? 386 MET B CA 1 ATOM 2457 C C . MET A 1 330 ? 26.739 -2.482 -19.007 1.00 7.55 ? 386 MET B C 1 ATOM 2458 O O . MET A 1 330 ? 26.188 -1.403 -19.239 1.00 5.47 ? 386 MET B O 1 ATOM 2459 C CB . MET A 1 330 ? 29.161 -1.831 -18.789 1.00 19.98 ? 386 MET B CB 1 ATOM 2460 C CG . MET A 1 330 ? 29.158 -1.885 -17.272 1.00 18.79 ? 386 MET B CG 1 ATOM 2461 S SD . MET A 1 330 ? 30.450 -0.787 -16.673 1.00 37.60 ? 386 MET B SD 1 ATOM 2462 C CE . MET A 1 330 ? 31.837 -1.406 -17.617 1.00 20.07 ? 386 MET B CE 1 ATOM 2463 N N . PHE A 1 331 ? 26.142 -3.468 -18.344 1.00 8.34 ? 387 PHE B N 1 ATOM 2464 C CA . PHE A 1 331 ? 24.838 -3.300 -17.692 1.00 11.36 ? 387 PHE B CA 1 ATOM 2465 C C . PHE A 1 331 ? 24.917 -3.775 -16.224 1.00 11.71 ? 387 PHE B C 1 ATOM 2466 O O . PHE A 1 331 ? 25.044 -4.969 -15.972 1.00 15.01 ? 387 PHE B O 1 ATOM 2467 C CB . PHE A 1 331 ? 23.785 -4.091 -18.495 1.00 13.73 ? 387 PHE B CB 1 ATOM 2468 C CG . PHE A 1 331 ? 22.410 -4.112 -17.881 1.00 9.60 ? 387 PHE B CG 1 ATOM 2469 C CD1 . PHE A 1 331 ? 21.877 -2.987 -17.270 1.00 5.49 ? 387 PHE B CD1 1 ATOM 2470 C CD2 . PHE A 1 331 ? 21.631 -5.257 -17.959 1.00 4.93 ? 387 PHE B CD2 1 ATOM 2471 C CE1 . PHE A 1 331 ? 20.599 -3.012 -16.709 1.00 2.00 ? 387 PHE B CE1 1 ATOM 2472 C CE2 . PHE A 1 331 ? 20.361 -5.288 -17.402 1.00 5.14 ? 387 PHE B CE2 1 ATOM 2473 C CZ . PHE A 1 331 ? 19.843 -4.157 -16.775 1.00 2.91 ? 387 PHE B CZ 1 ATOM 2474 N N . PHE A 1 332 ? 24.844 -2.842 -15.267 1.00 12.00 ? 388 PHE B N 1 ATOM 2475 C CA . PHE A 1 332 ? 24.904 -3.169 -13.820 1.00 6.61 ? 388 PHE B CA 1 ATOM 2476 C C . PHE A 1 332 ? 23.632 -2.696 -13.167 1.00 5.61 ? 388 PHE B C 1 ATOM 2477 O O . PHE A 1 332 ? 23.374 -1.488 -13.153 1.00 5.81 ? 388 PHE B O 1 ATOM 2478 C CB . PHE A 1 332 ? 26.049 -2.449 -13.096 1.00 2.00 ? 388 PHE B CB 1 ATOM 2479 C CG . PHE A 1 332 ? 27.420 -2.887 -13.516 1.00 8.75 ? 388 PHE B CG 1 ATOM 2480 C CD1 . PHE A 1 332 ? 27.600 -4.009 -14.320 1.00 4.11 ? 388 PHE B CD1 1 ATOM 2481 C CD2 . PHE A 1 332 ? 28.532 -2.170 -13.110 1.00 2.27 ? 388 PHE B CD2 1 ATOM 2482 C CE1 . PHE A 1 332 ? 28.867 -4.400 -14.713 1.00 6.93 ? 388 PHE B CE1 1 ATOM 2483 C CE2 . PHE A 1 332 ? 29.789 -2.553 -13.481 1.00 2.62 ? 388 PHE B CE2 1 ATOM 2484 C CZ . PHE A 1 332 ? 29.964 -3.671 -14.289 1.00 11.03 ? 388 PHE B CZ 1 ATOM 2485 N N . ALA A 1 333 ? 22.790 -3.639 -12.747 1.00 5.67 ? 389 ALA B N 1 ATOM 2486 C CA . ALA A 1 333 ? 21.618 -3.369 -11.908 1.00 2.00 ? 389 ALA B CA 1 ATOM 2487 C C . ALA A 1 333 ? 21.682 -3.848 -10.427 1.00 11.00 ? 389 ALA B C 1 ATOM 2488 O O . ALA A 1 333 ? 20.676 -3.819 -9.706 1.00 12.53 ? 389 ALA B O 1 ATOM 2489 C CB . ALA A 1 333 ? 20.319 -3.809 -12.615 1.00 2.00 ? 389 ALA B CB 1 ATOM 2490 N N . TRP A 1 334 ? 22.833 -4.352 -9.996 1.00 9.29 ? 390 TRP B N 1 ATOM 2491 C CA . TRP A 1 334 ? 22.937 -4.980 -8.670 1.00 4.51 ? 390 TRP B CA 1 ATOM 2492 C C . TRP A 1 334 ? 22.539 -4.100 -7.483 1.00 2.63 ? 390 TRP B C 1 ATOM 2493 O O . TRP A 1 334 ? 22.639 -2.877 -7.543 1.00 2.00 ? 390 TRP B O 1 ATOM 2494 C CB . TRP A 1 334 ? 24.318 -5.624 -8.441 1.00 10.05 ? 390 TRP B CB 1 ATOM 2495 C CG . TRP A 1 334 ? 25.485 -4.685 -8.391 1.00 9.79 ? 390 TRP B CG 1 ATOM 2496 C CD1 . TRP A 1 334 ? 26.090 -4.078 -9.447 1.00 13.18 ? 390 TRP B CD1 1 ATOM 2497 C CD2 . TRP A 1 334 ? 26.224 -4.293 -7.226 1.00 10.71 ? 390 TRP B CD2 1 ATOM 2498 N NE1 . TRP A 1 334 ? 27.135 -3.302 -9.014 1.00 18.32 ? 390 TRP B NE1 1 ATOM 2499 C CE2 . TRP A 1 334 ? 27.243 -3.424 -7.655 1.00 14.50 ? 390 TRP B CE2 1 ATOM 2500 C CE3 . TRP A 1 334 ? 26.109 -4.579 -5.864 1.00 8.40 ? 390 TRP B CE3 1 ATOM 2501 C CZ2 . TRP A 1 334 ? 28.144 -2.842 -6.769 1.00 17.27 ? 390 TRP B CZ2 1 ATOM 2502 C CZ3 . TRP A 1 334 ? 27.004 -4.003 -4.994 1.00 5.86 ? 390 TRP B CZ3 1 ATOM 2503 C CH2 . TRP A 1 334 ? 28.008 -3.145 -5.449 1.00 2.17 ? 390 TRP B CH2 1 ATOM 2504 N N . GLN A 1 335 ? 22.060 -4.750 -6.420 1.00 3.69 ? 391 GLN B N 1 ATOM 2505 C CA . GLN A 1 335 ? 21.534 -4.067 -5.235 1.00 2.77 ? 391 GLN B CA 1 ATOM 2506 C C . GLN A 1 335 ? 20.375 -3.144 -5.637 1.00 7.25 ? 391 GLN B C 1 ATOM 2507 O O . GLN A 1 335 ? 20.468 -1.910 -5.614 1.00 3.80 ? 391 GLN B O 1 ATOM 2508 C CB . GLN A 1 335 ? 22.637 -3.327 -4.446 1.00 2.54 ? 391 GLN B CB 1 ATOM 2509 C CG . GLN A 1 335 ? 22.347 -3.102 -2.962 1.00 2.00 ? 391 GLN B CG 1 ATOM 2510 C CD . GLN A 1 335 ? 22.184 -4.403 -2.169 1.00 8.90 ? 391 GLN B CD 1 ATOM 2511 O OE1 . GLN A 1 335 ? 21.082 -4.924 -2.058 1.00 5.88 ? 391 GLN B OE1 1 ATOM 2512 N NE2 . GLN A 1 335 ? 23.281 -4.921 -1.610 1.00 2.00 ? 391 GLN B NE2 1 ATOM 2513 N N . ASN A 1 336 ? 19.295 -3.785 -6.053 1.00 2.00 ? 392 ASN B N 1 ATOM 2514 C CA . ASN A 1 336 ? 18.013 -3.144 -6.222 1.00 7.39 ? 392 ASN B CA 1 ATOM 2515 C C . ASN A 1 336 ? 16.984 -4.146 -5.748 1.00 12.18 ? 392 ASN B C 1 ATOM 2516 O O . ASN A 1 336 ? 17.331 -5.129 -5.099 1.00 16.46 ? 392 ASN B O 1 ATOM 2517 C CB . ASN A 1 336 ? 17.762 -2.780 -7.675 1.00 7.60 ? 392 ASN B CB 1 ATOM 2518 C CG . ASN A 1 336 ? 18.557 -1.586 -8.110 1.00 11.61 ? 392 ASN B CG 1 ATOM 2519 O OD1 . ASN A 1 336 ? 18.269 -0.471 -7.696 1.00 12.95 ? 392 ASN B OD1 1 ATOM 2520 N ND2 . ASN A 1 336 ? 19.563 -1.806 -8.953 1.00 13.74 ? 392 ASN B ND2 1 ATOM 2521 N N . LYS A 1 337 ? 15.712 -3.877 -5.992 1.00 12.63 ? 393 LYS B N 1 ATOM 2522 C CA . LYS A 1 337 ? 14.729 -4.916 -5.815 1.00 16.65 ? 393 LYS B CA 1 ATOM 2523 C C . LYS A 1 337 ? 14.066 -5.195 -7.161 1.00 15.79 ? 393 LYS B C 1 ATOM 2524 O O . LYS A 1 337 ? 13.045 -4.605 -7.463 1.00 16.60 ? 393 LYS B O 1 ATOM 2525 C CB . LYS A 1 337 ? 13.707 -4.387 -4.814 1.00 18.89 ? 393 LYS B CB 1 ATOM 2526 C CG . LYS A 1 337 ? 14.373 -3.902 -3.525 1.00 16.70 ? 393 LYS B CG 1 ATOM 2527 C CD . LYS A 1 337 ? 13.711 -2.687 -2.919 1.00 19.79 ? 393 LYS B CD 1 ATOM 2528 C CE . LYS A 1 337 ? 12.209 -2.879 -2.804 1.00 41.23 ? 393 LYS B CE 1 ATOM 2529 N NZ . LYS A 1 337 ? 11.797 -4.235 -2.298 1.00 52.25 ? 393 LYS B NZ 1 ATOM 2530 N N . LEU A 1 338 ? 14.554 -6.195 -7.893 1.00 17.42 ? 394 LEU B N 1 ATOM 2531 C CA . LEU A 1 338 ? 14.103 -6.451 -9.261 1.00 2.00 ? 394 LEU B CA 1 ATOM 2532 C C . LEU A 1 338 ? 13.429 -7.811 -9.276 1.00 5.27 ? 394 LEU B C 1 ATOM 2533 O O . LEU A 1 338 ? 13.939 -8.768 -8.697 1.00 13.92 ? 394 LEU B O 1 ATOM 2534 C CB . LEU A 1 338 ? 15.275 -6.463 -10.240 1.00 2.00 ? 394 LEU B CB 1 ATOM 2535 C CG . LEU A 1 338 ? 15.912 -5.175 -10.763 1.00 3.41 ? 394 LEU B CG 1 ATOM 2536 C CD1 . LEU A 1 338 ? 16.879 -5.444 -11.924 1.00 2.00 ? 394 LEU B CD1 1 ATOM 2537 C CD2 . LEU A 1 338 ? 14.848 -4.191 -11.188 1.00 2.00 ? 394 LEU B CD2 1 ATOM 2538 N N . THR A 1 339 ? 12.283 -7.911 -9.932 1.00 6.14 ? 395 THR B N 1 ATOM 2539 C CA . THR A 1 339 ? 11.561 -9.173 -9.943 1.00 12.59 ? 395 THR B CA 1 ATOM 2540 C C . THR A 1 339 ? 11.463 -9.732 -11.358 1.00 13.59 ? 395 THR B C 1 ATOM 2541 O O . THR A 1 339 ? 11.942 -9.099 -12.301 1.00 16.60 ? 395 THR B O 1 ATOM 2542 C CB . THR A 1 339 ? 10.166 -9.025 -9.301 1.00 15.49 ? 395 THR B CB 1 ATOM 2543 O OG1 . THR A 1 339 ? 9.625 -7.731 -9.608 1.00 21.29 ? 395 THR B OG1 1 ATOM 2544 C CG2 . THR A 1 339 ? 10.274 -9.153 -7.797 1.00 13.06 ? 395 THR B CG2 1 ATOM 2545 N N . GLY A 1 340 ? 10.858 -10.917 -11.491 1.00 5.68 ? 396 GLY B N 1 ATOM 2546 C CA . GLY A 1 340 ? 10.655 -11.562 -12.780 1.00 9.90 ? 396 GLY B CA 1 ATOM 2547 C C . GLY A 1 340 ? 11.862 -12.292 -13.344 1.00 11.15 ? 396 GLY B C 1 ATOM 2548 O O . GLY A 1 340 ? 12.886 -12.425 -12.678 1.00 15.43 ? 396 GLY B O 1 ATOM 2549 N N . ASN A 1 341 ? 11.731 -12.783 -14.571 1.00 9.93 ? 397 ASN B N 1 ATOM 2550 C CA . ASN A 1 341 ? 12.838 -13.418 -15.278 1.00 7.84 ? 397 ASN B CA 1 ATOM 2551 C C . ASN A 1 341 ? 13.850 -12.404 -15.787 1.00 9.87 ? 397 ASN B C 1 ATOM 2552 O O . ASN A 1 341 ? 13.507 -11.274 -16.124 1.00 9.51 ? 397 ASN B O 1 ATOM 2553 C CB . ASN A 1 341 ? 12.335 -14.197 -16.501 1.00 5.55 ? 397 ASN B CB 1 ATOM 2554 C CG . ASN A 1 341 ? 11.631 -15.485 -16.132 1.00 10.27 ? 397 ASN B CG 1 ATOM 2555 O OD1 . ASN A 1 341 ? 12.229 -16.561 -16.163 1.00 17.81 ? 397 ASN B OD1 1 ATOM 2556 N ND2 . ASN A 1 341 ? 10.344 -15.388 -15.804 1.00 2.63 ? 397 ASN B ND2 1 ATOM 2557 N N . ILE A 1 342 ? 15.107 -12.819 -15.851 1.00 12.46 ? 398 ILE B N 1 ATOM 2558 C CA . ILE A 1 342 ? 16.057 -12.129 -16.685 1.00 9.98 ? 398 ILE B CA 1 ATOM 2559 C C . ILE A 1 342 ? 15.537 -12.415 -18.074 1.00 21.84 ? 398 ILE B C 1 ATOM 2560 O O . ILE A 1 342 ? 15.518 -13.577 -18.502 1.00 28.14 ? 398 ILE B O 1 ATOM 2561 C CB . ILE A 1 342 ? 17.459 -12.728 -16.504 1.00 10.71 ? 398 ILE B CB 1 ATOM 2562 C CG1 . ILE A 1 342 ? 18.033 -12.305 -15.140 1.00 9.71 ? 398 ILE B CG1 1 ATOM 2563 C CG2 . ILE A 1 342 ? 18.381 -12.303 -17.648 1.00 12.11 ? 398 ILE B CG2 1 ATOM 2564 C CD1 . ILE A 1 342 ? 18.997 -13.299 -14.520 1.00 7.50 ? 398 ILE B CD1 1 ATOM 2565 N N . PRO A 1 343 ? 15.084 -11.368 -18.779 1.00 21.34 ? 399 PRO B N 1 ATOM 2566 C CA . PRO A 1 343 ? 14.488 -11.489 -20.117 1.00 19.47 ? 399 PRO B CA 1 ATOM 2567 C C . PRO A 1 343 ? 15.459 -12.094 -21.113 1.00 23.36 ? 399 PRO B C 1 ATOM 2568 O O . PRO A 1 343 ? 16.600 -11.651 -21.161 1.00 2.00 ? 399 PRO B O 1 ATOM 2569 C CB . PRO A 1 343 ? 14.209 -10.037 -20.509 1.00 2.00 ? 399 PRO B CB 1 ATOM 2570 C CG . PRO A 1 343 ? 15.144 -9.240 -19.704 1.00 24.86 ? 399 PRO B CG 1 ATOM 2571 C CD . PRO A 1 343 ? 15.254 -9.962 -18.387 1.00 22.05 ? 399 PRO B CD 1 ATOM 2572 N N . GLN A 1 344 ? 15.009 -13.080 -21.892 1.00 26.98 ? 400 GLN B N 1 ATOM 2573 C CA . GLN A 1 344 ? 15.852 -13.729 -22.902 1.00 17.11 ? 400 GLN B CA 1 ATOM 2574 C C . GLN A 1 344 ? 16.436 -12.703 -23.876 1.00 10.33 ? 400 GLN B C 1 ATOM 2575 O O . GLN A 1 344 ? 17.613 -12.775 -24.243 1.00 7.76 ? 400 GLN B O 1 ATOM 2576 C CB . GLN A 1 344 ? 15.069 -14.827 -23.649 1.00 21.46 ? 400 GLN B CB 1 ATOM 2577 C CG . GLN A 1 344 ? 14.225 -14.376 -24.854 1.00 34.29 ? 400 GLN B CG 1 ATOM 2578 C CD . GLN A 1 344 ? 14.982 -14.459 -26.185 1.00 49.24 ? 400 GLN B CD 1 ATOM 2579 O OE1 . GLN A 1 344 ? 15.866 -15.302 -26.356 1.00 57.75 ? 400 GLN B OE1 1 ATOM 2580 N NE2 . GLN A 1 344 ? 14.637 -13.581 -27.126 1.00 48.17 ? 400 GLN B NE2 1 ATOM 2581 N N . SER A 1 345 ? 15.618 -11.713 -24.233 1.00 9.39 ? 401 SER B N 1 ATOM 2582 C CA . SER A 1 345 ? 15.944 -10.736 -25.249 1.00 2.00 ? 401 SER B CA 1 ATOM 2583 C C . SER A 1 345 ? 17.131 -9.859 -24.891 1.00 15.00 ? 401 SER B C 1 ATOM 2584 O O . SER A 1 345 ? 17.563 -9.041 -25.699 1.00 21.99 ? 401 SER B O 1 ATOM 2585 C CB . SER A 1 345 ? 14.747 -9.839 -25.484 1.00 13.14 ? 401 SER B CB 1 ATOM 2586 O OG . SER A 1 345 ? 14.634 -8.910 -24.426 1.00 20.21 ? 401 SER B OG 1 ATOM 2587 N N . LEU A 1 346 ? 17.637 -9.989 -23.672 1.00 10.07 ? 402 LEU B N 1 ATOM 2588 C CA . LEU A 1 346 ? 18.859 -9.291 -23.297 1.00 9.48 ? 402 LEU B CA 1 ATOM 2589 C C . LEU A 1 346 ? 20.063 -9.805 -24.096 1.00 8.14 ? 402 LEU B C 1 ATOM 2590 O O . LEU A 1 346 ? 21.030 -9.074 -24.320 1.00 10.82 ? 402 LEU B O 1 ATOM 2591 C CB . LEU A 1 346 ? 19.121 -9.404 -21.798 1.00 12.60 ? 402 LEU B CB 1 ATOM 2592 C CG . LEU A 1 346 ? 20.301 -8.542 -21.353 1.00 9.98 ? 402 LEU B CG 1 ATOM 2593 C CD1 . LEU A 1 346 ? 19.884 -7.099 -21.373 1.00 8.08 ? 402 LEU B CD1 1 ATOM 2594 C CD2 . LEU A 1 346 ? 20.810 -8.949 -19.990 1.00 6.10 ? 402 LEU B CD2 1 ATOM 2595 N N . SER A 1 347 ? 19.988 -11.047 -24.559 1.00 10.18 ? 403 SER B N 1 ATOM 2596 C CA . SER A 1 347 ? 21.058 -11.632 -25.371 1.00 16.72 ? 403 SER B CA 1 ATOM 2597 C C . SER A 1 347 ? 21.150 -11.060 -26.795 1.00 19.09 ? 403 SER B C 1 ATOM 2598 O O . SER A 1 347 ? 22.065 -11.398 -27.564 1.00 9.53 ? 403 SER B O 1 ATOM 2599 C CB . SER A 1 347 ? 20.861 -13.129 -25.476 1.00 15.00 ? 403 SER B CB 1 ATOM 2600 O OG . SER A 1 347 ? 19.719 -13.390 -26.266 1.00 15.89 ? 403 SER B OG 1 ATOM 2601 N N . GLN A 1 348 ? 20.201 -10.210 -27.167 1.00 20.78 ? 404 GLN B N 1 ATOM 2602 C CA . GLN A 1 348 ? 20.313 -9.538 -28.447 1.00 2.57 ? 404 GLN B CA 1 ATOM 2603 C C . GLN A 1 348 ? 21.212 -8.314 -28.370 1.00 15.83 ? 404 GLN B C 1 ATOM 2604 O O . GLN A 1 348 ? 21.411 -7.625 -29.361 1.00 20.19 ? 404 GLN B O 1 ATOM 2605 C CB . GLN A 1 348 ? 18.947 -9.159 -28.994 1.00 2.31 ? 404 GLN B CB 1 ATOM 2606 C CG . GLN A 1 348 ? 17.999 -10.330 -29.128 1.00 19.76 ? 404 GLN B CG 1 ATOM 2607 C CD . GLN A 1 348 ? 16.716 -9.934 -29.811 1.00 16.10 ? 404 GLN B CD 1 ATOM 2608 O OE1 . GLN A 1 348 ? 16.698 -9.026 -30.642 1.00 17.48 ? 404 GLN B OE1 1 ATOM 2609 N NE2 . GLN A 1 348 ? 15.627 -10.597 -29.449 1.00 15.63 ? 404 GLN B NE2 1 ATOM 2610 N N . CYS A 1 349 ? 21.757 -8.016 -27.200 1.00 18.67 ? 405 CYS B N 1 ATOM 2611 C CA . CYS A 1 349 ? 22.748 -6.955 -27.166 1.00 20.13 ? 405 CYS B CA 1 ATOM 2612 C C . CYS A 1 349 ? 24.056 -7.698 -27.356 1.00 31.70 ? 405 CYS B C 1 ATOM 2613 O O . CYS A 1 349 ? 24.600 -8.289 -26.413 1.00 31.04 ? 405 CYS B O 1 ATOM 2614 C CB . CYS A 1 349 ? 22.728 -6.245 -25.813 1.00 9.89 ? 405 CYS B CB 1 ATOM 2615 S SG . CYS A 1 349 ? 21.103 -5.622 -25.273 1.00 10.53 ? 405 CYS B SG 1 ATOM 2616 N N . ARG A 1 350 ? 24.596 -7.617 -28.568 1.00 25.56 ? 406 ARG B N 1 ATOM 2617 C CA . ARG A 1 350 ? 25.651 -8.541 -28.952 1.00 19.39 ? 406 ARG B CA 1 ATOM 2618 C C . ARG A 1 350 ? 26.990 -8.029 -28.471 1.00 3.72 ? 406 ARG B C 1 ATOM 2619 O O . ARG A 1 350 ? 27.962 -8.766 -28.459 1.00 10.50 ? 406 ARG B O 1 ATOM 2620 C CB . ARG A 1 350 ? 25.665 -8.780 -30.468 1.00 17.68 ? 406 ARG B CB 1 ATOM 2621 C CG . ARG A 1 350 ? 24.375 -9.356 -31.081 1.00 10.71 ? 406 ARG B CG 1 ATOM 2622 C CD . ARG A 1 350 ? 23.942 -10.671 -30.450 1.00 16.33 ? 406 ARG B CD 1 ATOM 2623 N NE . ARG A 1 350 ? 24.924 -11.744 -30.579 1.00 21.27 ? 406 ARG B NE 1 ATOM 2624 C CZ . ARG A 1 350 ? 24.886 -12.871 -29.870 1.00 17.82 ? 406 ARG B CZ 1 ATOM 2625 N NH1 . ARG A 1 350 ? 23.912 -13.063 -28.985 1.00 7.15 ? 406 ARG B NH1 1 ATOM 2626 N NH2 . ARG A 1 350 ? 25.816 -13.806 -30.041 1.00 18.10 ? 406 ARG B NH2 1 ATOM 2627 N N . GLU A 1 351 ? 27.023 -6.766 -28.056 1.00 3.49 ? 407 GLU B N 1 ATOM 2628 C CA . GLU A 1 351 ? 28.252 -6.147 -27.586 1.00 6.48 ? 407 GLU B CA 1 ATOM 2629 C C . GLU A 1 351 ? 28.457 -6.203 -26.060 1.00 6.38 ? 407 GLU B C 1 ATOM 2630 O O . GLU A 1 351 ? 29.420 -5.628 -25.556 1.00 8.34 ? 407 GLU B O 1 ATOM 2631 C CB . GLU A 1 351 ? 28.289 -4.690 -28.041 1.00 20.49 ? 407 GLU B CB 1 ATOM 2632 C CG . GLU A 1 351 ? 28.347 -4.513 -29.541 1.00 32.54 ? 407 GLU B CG 1 ATOM 2633 C CD . GLU A 1 351 ? 29.566 -5.169 -30.148 1.00 39.14 ? 407 GLU B CD 1 ATOM 2634 O OE1 . GLU A 1 351 ? 29.377 -6.017 -31.040 1.00 40.83 ? 407 GLU B OE1 1 ATOM 2635 O OE2 . GLU A 1 351 ? 30.704 -4.839 -29.733 1.00 40.61 ? 407 GLU B OE2 1 ATOM 2636 N N . LEU A 1 352 ? 27.545 -6.847 -25.324 1.00 5.54 ? 408 LEU B N 1 ATOM 2637 C CA . LEU A 1 352 ? 27.669 -6.904 -23.879 1.00 8.28 ? 408 LEU B CA 1 ATOM 2638 C C . LEU A 1 352 ? 28.970 -7.570 -23.455 1.00 25.35 ? 408 LEU B C 1 ATOM 2639 O O . LEU A 1 352 ? 29.222 -8.731 -23.784 1.00 29.21 ? 408 LEU B O 1 ATOM 2640 C CB . LEU A 1 352 ? 26.497 -7.675 -23.270 1.00 3.06 ? 408 LEU B CB 1 ATOM 2641 C CG . LEU A 1 352 ? 25.215 -6.875 -23.004 1.00 9.12 ? 408 LEU B CG 1 ATOM 2642 C CD1 . LEU A 1 352 ? 24.122 -7.804 -22.524 1.00 2.50 ? 408 LEU B CD1 1 ATOM 2643 C CD2 . LEU A 1 352 ? 25.439 -5.740 -22.001 1.00 2.45 ? 408 LEU B CD2 1 ATOM 2644 N N . GLN A 1 353 ? 29.801 -6.812 -22.739 1.00 26.66 ? 409 GLN B N 1 ATOM 2645 C CA . GLN A 1 353 ? 30.976 -7.349 -22.062 1.00 22.84 ? 409 GLN B CA 1 ATOM 2646 C C . GLN A 1 353 ? 30.684 -7.840 -20.650 1.00 15.63 ? 409 GLN B C 1 ATOM 2647 O O . GLN A 1 353 ? 31.198 -8.868 -20.219 1.00 18.81 ? 409 GLN B O 1 ATOM 2648 C CB . GLN A 1 353 ? 32.120 -6.346 -22.086 1.00 4.21 ? 409 GLN B CB 1 ATOM 2649 C CG . GLN A 1 353 ? 32.440 -5.880 -23.469 1.00 4.36 ? 409 GLN B CG 1 ATOM 2650 C CD . GLN A 1 353 ? 33.310 -4.655 -23.484 1.00 4.46 ? 409 GLN B CD 1 ATOM 2651 O OE1 . GLN A 1 353 ? 33.493 -3.996 -22.467 1.00 26.65 ? 409 GLN B OE1 1 ATOM 2652 N NE2 . GLN A 1 353 ? 33.851 -4.335 -24.642 1.00 11.05 ? 409 GLN B NE2 1 ATOM 2653 N N . ALA A 1 354 ? 29.874 -7.077 -19.922 1.00 12.32 ? 410 ALA B N 1 ATOM 2654 C CA . ALA A 1 354 ? 29.631 -7.354 -18.501 1.00 12.03 ? 410 ALA B CA 1 ATOM 2655 C C . ALA A 1 354 ? 28.184 -7.178 -18.038 1.00 3.00 ? 410 ALA B C 1 ATOM 2656 O O . ALA A 1 354 ? 27.573 -6.148 -18.276 1.00 16.59 ? 410 ALA B O 1 ATOM 2657 C CB . ALA A 1 354 ? 30.549 -6.499 -17.652 1.00 3.48 ? 410 ALA B CB 1 ATOM 2658 N N . ILE A 1 355 ? 27.657 -8.182 -17.349 1.00 17.62 ? 411 ILE B N 1 ATOM 2659 C CA . ILE A 1 355 ? 26.360 -8.064 -16.688 1.00 10.25 ? 411 ILE B CA 1 ATOM 2660 C C . ILE A 1 355 ? 26.495 -8.332 -15.194 1.00 11.27 ? 411 ILE B C 1 ATOM 2661 O O . ILE A 1 355 ? 27.062 -9.351 -14.806 1.00 13.89 ? 411 ILE B O 1 ATOM 2662 C CB . ILE A 1 355 ? 25.347 -9.077 -17.258 1.00 18.15 ? 411 ILE B CB 1 ATOM 2663 C CG1 . ILE A 1 355 ? 25.112 -8.828 -18.755 1.00 20.74 ? 411 ILE B CG1 1 ATOM 2664 C CG2 . ILE A 1 355 ? 24.032 -9.020 -16.487 1.00 21.66 ? 411 ILE B CG2 1 ATOM 2665 C CD1 . ILE A 1 355 ? 24.879 -10.090 -19.528 1.00 2.78 ? 411 ILE B CD1 1 ATOM 2666 N N . ASP A 1 356 ? 26.000 -7.419 -14.356 1.00 8.95 ? 412 ASP B N 1 ATOM 2667 C CA . ASP A 1 356 ? 25.845 -7.729 -12.941 1.00 11.30 ? 412 ASP B CA 1 ATOM 2668 C C . ASP A 1 356 ? 24.422 -7.451 -12.492 1.00 10.23 ? 412 ASP B C 1 ATOM 2669 O O . ASP A 1 356 ? 24.008 -6.300 -12.373 1.00 20.87 ? 412 ASP B O 1 ATOM 2670 C CB . ASP A 1 356 ? 26.804 -6.880 -12.106 1.00 21.85 ? 412 ASP B CB 1 ATOM 2671 C CG . ASP A 1 356 ? 27.023 -7.443 -10.709 1.00 17.72 ? 412 ASP B CG 1 ATOM 2672 O OD1 . ASP A 1 356 ? 26.177 -8.227 -10.239 1.00 9.15 ? 412 ASP B OD1 1 ATOM 2673 O OD2 . ASP A 1 356 ? 28.053 -7.113 -10.097 1.00 2.62 ? 412 ASP B OD2 1 ATOM 2674 N N . LEU A 1 357 ? 23.682 -8.528 -12.261 1.00 6.68 ? 413 LEU B N 1 ATOM 2675 C CA . LEU A 1 357 ? 22.312 -8.482 -11.748 1.00 7.45 ? 413 LEU B CA 1 ATOM 2676 C C . LEU A 1 357 ? 22.186 -8.885 -10.274 1.00 10.08 ? 413 LEU B C 1 ATOM 2677 O O . LEU A 1 357 ? 21.083 -9.147 -9.782 1.00 8.31 ? 413 LEU B O 1 ATOM 2678 C CB . LEU A 1 357 ? 21.351 -9.224 -12.678 1.00 8.54 ? 413 LEU B CB 1 ATOM 2679 C CG . LEU A 1 357 ? 21.387 -8.566 -14.071 1.00 6.35 ? 413 LEU B CG 1 ATOM 2680 C CD1 . LEU A 1 357 ? 20.558 -9.318 -15.092 1.00 2.00 ? 413 LEU B CD1 1 ATOM 2681 C CD2 . LEU A 1 357 ? 20.943 -7.106 -13.988 1.00 4.85 ? 413 LEU B CD2 1 ATOM 2682 N N . SER A 1 358 ? 23.335 -9.002 -9.609 1.00 12.00 ? 414 SER B N 1 ATOM 2683 C CA . SER A 1 358 ? 23.445 -9.522 -8.243 1.00 2.00 ? 414 SER B CA 1 ATOM 2684 C C . SER A 1 358 ? 22.610 -8.778 -7.218 1.00 19.64 ? 414 SER B C 1 ATOM 2685 O O . SER A 1 358 ? 22.269 -7.615 -7.413 1.00 14.24 ? 414 SER B O 1 ATOM 2686 C CB . SER A 1 358 ? 24.895 -9.472 -7.769 1.00 2.15 ? 414 SER B CB 1 ATOM 2687 O OG . SER A 1 358 ? 25.670 -10.464 -8.404 1.00 8.96 ? 414 SER B OG 1 ATOM 2688 N N . TYR A 1 359 ? 22.259 -9.468 -6.134 1.00 2.00 ? 415 TYR B N 1 ATOM 2689 C CA . TYR A 1 359 ? 21.545 -8.832 -5.038 1.00 6.24 ? 415 TYR B CA 1 ATOM 2690 C C . TYR A 1 359 ? 20.232 -8.232 -5.547 1.00 6.38 ? 415 TYR B C 1 ATOM 2691 O O . TYR A 1 359 ? 20.046 -7.016 -5.586 1.00 6.69 ? 415 TYR B O 1 ATOM 2692 C CB . TYR A 1 359 ? 22.429 -7.782 -4.336 1.00 2.00 ? 415 TYR B CB 1 ATOM 2693 C CG . TYR A 1 359 ? 23.572 -8.395 -3.563 1.00 12.11 ? 415 TYR B CG 1 ATOM 2694 C CD1 . TYR A 1 359 ? 23.315 -9.204 -2.450 1.00 15.19 ? 415 TYR B CD1 1 ATOM 2695 C CD2 . TYR A 1 359 ? 24.901 -8.173 -3.929 1.00 2.00 ? 415 TYR B CD2 1 ATOM 2696 C CE1 . TYR A 1 359 ? 24.337 -9.782 -1.721 1.00 2.04 ? 415 TYR B CE1 1 ATOM 2697 C CE2 . TYR A 1 359 ? 25.942 -8.751 -3.210 1.00 2.26 ? 415 TYR B CE2 1 ATOM 2698 C CZ . TYR A 1 359 ? 25.643 -9.558 -2.100 1.00 15.37 ? 415 TYR B CZ 1 ATOM 2699 O OH . TYR A 1 359 ? 26.629 -10.151 -1.353 1.00 10.70 ? 415 TYR B OH 1 ATOM 2700 N N . ASN A 1 360 ? 19.335 -9.114 -5.958 1.00 9.67 ? 416 ASN B N 1 ATOM 2701 C CA . ASN A 1 360 ? 18.019 -8.737 -6.413 1.00 2.00 ? 416 ASN B CA 1 ATOM 2702 C C . ASN A 1 360 ? 17.053 -9.883 -6.138 1.00 18.56 ? 416 ASN B C 1 ATOM 2703 O O . ASN A 1 360 ? 17.408 -10.870 -5.499 1.00 21.01 ? 416 ASN B O 1 ATOM 2704 C CB . ASN A 1 360 ? 18.061 -8.445 -7.902 1.00 2.00 ? 416 ASN B CB 1 ATOM 2705 C CG . ASN A 1 360 ? 18.293 -6.997 -8.198 1.00 2.00 ? 416 ASN B CG 1 ATOM 2706 O OD1 . ASN A 1 360 ? 17.524 -6.147 -7.774 1.00 2.00 ? 416 ASN B OD1 1 ATOM 2707 N ND2 . ASN A 1 360 ? 19.353 -6.700 -8.938 1.00 2.00 ? 416 ASN B ND2 1 ATOM 2708 N N . SER A 1 361 ? 15.820 -9.739 -6.596 1.00 15.78 ? 417 SER B N 1 ATOM 2709 C CA . SER A 1 361 ? 14.823 -10.794 -6.466 1.00 20.24 ? 417 SER B CA 1 ATOM 2710 C C . SER A 1 361 ? 14.563 -11.678 -7.699 1.00 25.00 ? 417 SER B C 1 ATOM 2711 O O . SER A 1 361 ? 13.607 -12.450 -7.686 1.00 34.69 ? 417 SER B O 1 ATOM 2712 C CB . SER A 1 361 ? 13.527 -10.217 -5.922 1.00 24.29 ? 417 SER B CB 1 ATOM 2713 O OG . SER A 1 361 ? 13.804 -9.519 -4.728 1.00 27.12 ? 417 SER B OG 1 ATOM 2714 N N . LEU A 1 362 ? 15.362 -11.543 -8.760 1.00 19.05 ? 418 LEU B N 1 ATOM 2715 C CA . LEU A 1 362 ? 15.058 -12.193 -10.051 1.00 23.53 ? 418 LEU B CA 1 ATOM 2716 C C . LEU A 1 362 ? 14.793 -13.687 -9.898 1.00 22.37 ? 418 LEU B C 1 ATOM 2717 O O . LEU A 1 362 ? 15.392 -14.349 -9.042 1.00 17.07 ? 418 LEU B O 1 ATOM 2718 C CB . LEU A 1 362 ? 16.166 -11.957 -11.089 1.00 2.00 ? 418 LEU B CB 1 ATOM 2719 C CG . LEU A 1 362 ? 16.717 -10.532 -11.167 1.00 2.00 ? 418 LEU B CG 1 ATOM 2720 C CD1 . LEU A 1 362 ? 18.038 -10.522 -11.898 1.00 2.00 ? 418 LEU B CD1 1 ATOM 2721 C CD2 . LEU A 1 362 ? 15.731 -9.614 -11.828 1.00 2.00 ? 418 LEU B CD2 1 ATOM 2722 N N . SER A 1 363 ? 13.864 -14.202 -10.701 1.00 2.00 ? 419 SER B N 1 ATOM 2723 C CA . SER A 1 363 ? 13.439 -15.592 -10.572 1.00 10.96 ? 419 SER B CA 1 ATOM 2724 C C . SER A 1 363 ? 13.560 -16.395 -11.874 1.00 14.95 ? 419 SER B C 1 ATOM 2725 O O . SER A 1 363 ? 14.144 -15.931 -12.856 1.00 26.20 ? 419 SER B O 1 ATOM 2726 C CB . SER A 1 363 ? 12.020 -15.697 -9.978 1.00 9.38 ? 419 SER B CB 1 ATOM 2727 O OG . SER A 1 363 ? 11.277 -14.496 -10.114 1.00 7.91 ? 419 SER B OG 1 ATOM 2728 N N . GLY A 1 364 ? 13.042 -17.619 -11.859 1.00 2.00 ? 420 GLY B N 1 ATOM 2729 C CA . GLY A 1 364 ? 13.037 -18.456 -13.042 1.00 8.05 ? 420 GLY B CA 1 ATOM 2730 C C . GLY A 1 364 ? 14.430 -18.912 -13.428 1.00 8.89 ? 420 GLY B C 1 ATOM 2731 O O . GLY A 1 364 ? 15.389 -18.760 -12.650 1.00 10.31 ? 420 GLY B O 1 ATOM 2732 N N . SER A 1 365 ? 14.561 -19.484 -14.620 1.00 5.45 ? 421 SER B N 1 ATOM 2733 C CA . SER A 1 365 ? 15.873 -19.913 -15.063 1.00 4.11 ? 421 SER B CA 1 ATOM 2734 C C . SER A 1 365 ? 16.668 -18.755 -15.615 1.00 9.24 ? 421 SER B C 1 ATOM 2735 O O . SER A 1 365 ? 16.162 -17.641 -15.743 1.00 10.81 ? 421 SER B O 1 ATOM 2736 C CB . SER A 1 365 ? 15.751 -20.984 -16.123 1.00 7.21 ? 421 SER B CB 1 ATOM 2737 O OG . SER A 1 365 ? 15.312 -22.190 -15.541 1.00 14.46 ? 421 SER B OG 1 ATOM 2738 N N . ILE A 1 366 ? 17.924 -19.039 -15.935 1.00 10.99 ? 422 ILE B N 1 ATOM 2739 C CA . ILE A 1 366 ? 18.806 -18.089 -16.573 1.00 2.78 ? 422 ILE B CA 1 ATOM 2740 C C . ILE A 1 366 ? 18.653 -18.486 -18.013 1.00 29.96 ? 422 ILE B C 1 ATOM 2741 O O . ILE A 1 366 ? 18.937 -19.640 -18.374 1.00 24.11 ? 422 ILE B O 1 ATOM 2742 C CB . ILE A 1 366 ? 20.279 -18.315 -16.156 1.00 8.66 ? 422 ILE B CB 1 ATOM 2743 C CG1 . ILE A 1 366 ? 20.446 -18.262 -14.631 1.00 13.57 ? 422 ILE B CG1 1 ATOM 2744 C CG2 . ILE A 1 366 ? 21.179 -17.285 -16.800 1.00 13.49 ? 422 ILE B CG2 1 ATOM 2745 C CD1 . ILE A 1 366 ? 21.768 -18.822 -14.115 1.00 11.76 ? 422 ILE B CD1 1 ATOM 2746 N N . PRO A 1 367 ? 18.170 -17.551 -18.843 1.00 27.07 ? 423 PRO B N 1 ATOM 2747 C CA . PRO A 1 367 ? 17.890 -17.861 -20.247 1.00 16.18 ? 423 PRO B CA 1 ATOM 2748 C C . PRO A 1 367 ? 19.179 -18.338 -20.885 1.00 21.99 ? 423 PRO B C 1 ATOM 2749 O O . PRO A 1 367 ? 20.250 -17.890 -20.462 1.00 23.64 ? 423 PRO B O 1 ATOM 2750 C CB . PRO A 1 367 ? 17.449 -16.517 -20.817 1.00 10.41 ? 423 PRO B CB 1 ATOM 2751 C CG . PRO A 1 367 ? 18.066 -15.498 -19.919 1.00 21.79 ? 423 PRO B CG 1 ATOM 2752 C CD . PRO A 1 367 ? 18.042 -16.112 -18.551 1.00 27.97 ? 423 PRO B CD 1 ATOM 2753 N N . LYS A 1 368 ? 19.094 -19.260 -21.841 1.00 16.30 ? 424 LYS B N 1 ATOM 2754 C CA . LYS A 1 368 ? 20.303 -19.870 -22.383 1.00 8.47 ? 424 LYS B CA 1 ATOM 2755 C C . LYS A 1 368 ? 20.984 -18.932 -23.371 1.00 8.45 ? 424 LYS B C 1 ATOM 2756 O O . LYS A 1 368 ? 22.183 -19.013 -23.593 1.00 14.91 ? 424 LYS B O 1 ATOM 2757 C CB . LYS A 1 368 ? 19.992 -21.221 -23.029 1.00 12.43 ? 424 LYS B CB 1 ATOM 2758 C CG . LYS A 1 368 ? 19.022 -21.119 -24.182 1.00 26.57 ? 424 LYS B CG 1 ATOM 2759 C CD . LYS A 1 368 ? 18.880 -22.433 -24.926 1.00 32.94 ? 424 LYS B CD 1 ATOM 2760 C CE . LYS A 1 368 ? 17.829 -22.324 -26.017 1.00 29.72 ? 424 LYS B CE 1 ATOM 2761 N NZ . LYS A 1 368 ? 17.466 -23.671 -26.523 1.00 29.94 ? 424 LYS B NZ 1 ATOM 2762 N N . GLU A 1 369 ? 20.215 -18.020 -23.939 1.00 11.29 ? 425 GLU B N 1 ATOM 2763 C CA . GLU A 1 369 ? 20.709 -17.157 -25.003 1.00 15.91 ? 425 GLU B CA 1 ATOM 2764 C C . GLU A 1 369 ? 21.830 -16.230 -24.511 1.00 22.31 ? 425 GLU B C 1 ATOM 2765 O O . GLU A 1 369 ? 22.621 -15.717 -25.311 1.00 26.46 ? 425 GLU B O 1 ATOM 2766 C CB . GLU A 1 369 ? 19.552 -16.334 -25.589 1.00 16.79 ? 425 GLU B CB 1 ATOM 2767 C CG . GLU A 1 369 ? 18.452 -17.124 -26.304 1.00 20.79 ? 425 GLU B CG 1 ATOM 2768 C CD . GLU A 1 369 ? 17.499 -17.877 -25.373 1.00 23.84 ? 425 GLU B CD 1 ATOM 2769 O OE1 . GLU A 1 369 ? 17.554 -17.684 -24.143 1.00 27.92 ? 425 GLU B OE1 1 ATOM 2770 O OE2 . GLU A 1 369 ? 16.688 -18.678 -25.878 1.00 28.47 ? 425 GLU B OE2 1 ATOM 2771 N N . ILE A 1 370 ? 21.895 -16.019 -23.197 1.00 15.06 ? 426 ILE B N 1 ATOM 2772 C CA . ILE A 1 370 ? 22.888 -15.121 -22.609 1.00 14.12 ? 426 ILE B CA 1 ATOM 2773 C C . ILE A 1 370 ? 24.291 -15.703 -22.766 1.00 17.75 ? 426 ILE B C 1 ATOM 2774 O O . ILE A 1 370 ? 25.281 -14.973 -22.819 1.00 22.85 ? 426 ILE B O 1 ATOM 2775 C CB . ILE A 1 370 ? 22.597 -14.854 -21.105 1.00 12.21 ? 426 ILE B CB 1 ATOM 2776 C CG1 . ILE A 1 370 ? 22.628 -13.358 -20.802 1.00 8.18 ? 426 ILE B CG1 1 ATOM 2777 C CG2 . ILE A 1 370 ? 23.580 -15.596 -20.208 1.00 3.49 ? 426 ILE B CG2 1 ATOM 2778 C CD1 . ILE A 1 370 ? 21.451 -12.608 -21.382 1.00 7.90 ? 426 ILE B CD1 1 ATOM 2779 N N . PHE A 1 371 ? 24.361 -17.027 -22.849 1.00 16.73 ? 427 PHE B N 1 ATOM 2780 C CA . PHE A 1 371 ? 25.628 -17.731 -22.986 1.00 21.97 ? 427 PHE B CA 1 ATOM 2781 C C . PHE A 1 371 ? 26.026 -17.778 -24.459 1.00 31.79 ? 427 PHE B C 1 ATOM 2782 O O . PHE A 1 371 ? 27.063 -18.325 -24.831 1.00 33.04 ? 427 PHE B O 1 ATOM 2783 C CB . PHE A 1 371 ? 25.511 -19.138 -22.393 1.00 19.44 ? 427 PHE B CB 1 ATOM 2784 C CG . PHE A 1 371 ? 25.300 -19.149 -20.894 1.00 24.24 ? 427 PHE B CG 1 ATOM 2785 C CD1 . PHE A 1 371 ? 26.371 -18.946 -20.023 1.00 24.08 ? 427 PHE B CD1 1 ATOM 2786 C CD2 . PHE A 1 371 ? 24.041 -19.356 -20.357 1.00 22.32 ? 427 PHE B CD2 1 ATOM 2787 C CE1 . PHE A 1 371 ? 26.191 -18.949 -18.649 1.00 21.03 ? 427 PHE B CE1 1 ATOM 2788 C CE2 . PHE A 1 371 ? 23.855 -19.365 -18.981 1.00 24.57 ? 427 PHE B CE2 1 ATOM 2789 C CZ . PHE A 1 371 ? 24.933 -19.163 -18.125 1.00 22.58 ? 427 PHE B CZ 1 ATOM 2790 N N . GLY A 1 372 ? 25.179 -17.191 -25.296 1.00 32.25 ? 428 GLY B N 1 ATOM 2791 C CA . GLY A 1 372 ? 25.474 -17.053 -26.703 1.00 22.67 ? 428 GLY B CA 1 ATOM 2792 C C . GLY A 1 372 ? 26.223 -15.763 -26.940 1.00 17.23 ? 428 GLY B C 1 ATOM 2793 O O . GLY A 1 372 ? 26.542 -15.415 -28.084 1.00 11.74 ? 428 GLY B O 1 ATOM 2794 N N . LEU A 1 373 ? 26.508 -15.048 -25.856 1.00 4.57 ? 429 LEU B N 1 ATOM 2795 C CA . LEU A 1 373 ? 27.197 -13.778 -25.970 1.00 4.51 ? 429 LEU B CA 1 ATOM 2796 C C . LEU A 1 373 ? 28.680 -14.042 -26.137 1.00 18.40 ? 429 LEU B C 1 ATOM 2797 O O . LEU A 1 373 ? 29.308 -14.693 -25.301 1.00 12.56 ? 429 LEU B O 1 ATOM 2798 C CB . LEU A 1 373 ? 26.916 -12.890 -24.764 1.00 11.94 ? 429 LEU B CB 1 ATOM 2799 C CG . LEU A 1 373 ? 25.493 -12.337 -24.730 1.00 10.59 ? 429 LEU B CG 1 ATOM 2800 C CD1 . LEU A 1 373 ? 25.195 -11.656 -23.391 1.00 10.36 ? 429 LEU B CD1 1 ATOM 2801 C CD2 . LEU A 1 373 ? 25.282 -11.379 -25.903 1.00 4.95 ? 429 LEU B CD2 1 ATOM 2802 N N . ARG A 1 374 ? 29.221 -13.564 -27.250 1.00 23.10 ? 430 ARG B N 1 ATOM 2803 C CA . ARG A 1 374 ? 30.585 -13.889 -27.643 1.00 21.14 ? 430 ARG B CA 1 ATOM 2804 C C . ARG A 1 374 ? 31.641 -13.000 -26.997 1.00 18.03 ? 430 ARG B C 1 ATOM 2805 O O . ARG A 1 374 ? 32.808 -13.370 -26.940 1.00 20.42 ? 430 ARG B O 1 ATOM 2806 C CB . ARG A 1 374 ? 30.711 -13.859 -29.168 1.00 23.42 ? 430 ARG B CB 1 ATOM 2807 C CG . ARG A 1 374 ? 29.977 -15.003 -29.868 1.00 38.40 ? 430 ARG B CG 1 ATOM 2808 C CD . ARG A 1 374 ? 30.268 -15.029 -31.374 1.00 51.34 ? 430 ARG B CD 1 ATOM 2809 N NE . ARG A 1 374 ? 31.674 -14.741 -31.648 1.00 60.16 ? 430 ARG B NE 1 ATOM 2810 C CZ . ARG A 1 374 ? 32.106 -13.633 -32.242 1.00 62.64 ? 430 ARG B CZ 1 ATOM 2811 N NH1 . ARG A 1 374 ? 31.239 -12.716 -32.648 1.00 59.94 ? 430 ARG B NH1 1 ATOM 2812 N NH2 . ARG A 1 374 ? 33.404 -13.445 -32.437 1.00 63.77 ? 430 ARG B NH2 1 ATOM 2813 N N . ASN A 1 375 ? 31.245 -11.806 -26.572 1.00 17.78 ? 431 ASN B N 1 ATOM 2814 C CA . ASN A 1 375 ? 32.166 -10.888 -25.899 1.00 20.63 ? 431 ASN B CA 1 ATOM 2815 C C . ASN A 1 375 ? 32.048 -10.752 -24.361 1.00 17.39 ? 431 ASN B C 1 ATOM 2816 O O . ASN A 1 375 ? 32.709 -9.910 -23.752 1.00 15.57 ? 431 ASN B O 1 ATOM 2817 C CB . ASN A 1 375 ? 32.218 -9.536 -26.619 1.00 31.44 ? 431 ASN B CB 1 ATOM 2818 C CG . ASN A 1 375 ? 33.565 -9.281 -27.275 1.00 39.65 ? 431 ASN B CG 1 ATOM 2819 O OD1 . ASN A 1 375 ? 33.681 -9.204 -28.511 1.00 37.88 ? 431 ASN B OD1 1 ATOM 2820 N ND2 . ASN A 1 375 ? 34.601 -9.148 -26.446 1.00 43.74 ? 431 ASN B ND2 1 ATOM 2821 N N . LEU A 1 376 ? 31.181 -11.553 -23.748 1.00 16.01 ? 432 LEU B N 1 ATOM 2822 C CA . LEU A 1 376 ? 30.882 -11.419 -22.331 1.00 4.65 ? 432 LEU B CA 1 ATOM 2823 C C . LEU A 1 376 ? 31.979 -12.063 -21.489 1.00 17.15 ? 432 LEU B C 1 ATOM 2824 O O . LEU A 1 376 ? 32.173 -13.277 -21.532 1.00 16.70 ? 432 LEU B O 1 ATOM 2825 C CB . LEU A 1 376 ? 29.544 -12.106 -22.046 1.00 4.38 ? 432 LEU B CB 1 ATOM 2826 C CG . LEU A 1 376 ? 28.817 -11.948 -20.707 1.00 5.07 ? 432 LEU B CG 1 ATOM 2827 C CD1 . LEU A 1 376 ? 28.367 -10.523 -20.494 1.00 8.18 ? 432 LEU B CD1 1 ATOM 2828 C CD2 . LEU A 1 376 ? 27.622 -12.875 -20.653 1.00 5.60 ? 432 LEU B CD2 1 ATOM 2829 N N . THR A 1 377 ? 32.700 -11.241 -20.727 1.00 19.88 ? 433 THR B N 1 ATOM 2830 C CA . THR A 1 377 ? 33.688 -11.733 -19.767 1.00 16.56 ? 433 THR B CA 1 ATOM 2831 C C . THR A 1 377 ? 33.196 -11.820 -18.318 1.00 17.65 ? 433 THR B C 1 ATOM 2832 O O . THR A 1 377 ? 33.822 -12.486 -17.490 1.00 10.47 ? 433 THR B O 1 ATOM 2833 C CB . THR A 1 377 ? 34.917 -10.842 -19.781 1.00 9.68 ? 433 THR B CB 1 ATOM 2834 O OG1 . THR A 1 377 ? 34.529 -9.520 -19.402 1.00 14.09 ? 433 THR B OG1 1 ATOM 2835 C CG2 . THR A 1 377 ? 35.488 -10.789 -21.174 1.00 14.59 ? 433 THR B CG2 1 ATOM 2836 N N . LYS A 1 378 ? 32.072 -11.170 -18.017 1.00 13.38 ? 434 LYS B N 1 ATOM 2837 C CA . LYS A 1 378 ? 31.566 -11.152 -16.646 1.00 7.71 ? 434 LYS B CA 1 ATOM 2838 C C . LYS A 1 378 ? 30.058 -11.339 -16.567 1.00 7.68 ? 434 LYS B C 1 ATOM 2839 O O . LYS A 1 378 ? 29.295 -10.482 -17.015 1.00 3.67 ? 434 LYS B O 1 ATOM 2840 C CB . LYS A 1 378 ? 31.939 -9.841 -15.948 1.00 4.19 ? 434 LYS B CB 1 ATOM 2841 C CG . LYS A 1 378 ? 33.414 -9.679 -15.667 1.00 5.73 ? 434 LYS B CG 1 ATOM 2842 C CD . LYS A 1 378 ? 33.728 -8.271 -15.211 1.00 4.44 ? 434 LYS B CD 1 ATOM 2843 C CE . LYS A 1 378 ? 35.198 -7.962 -15.398 1.00 12.39 ? 434 LYS B CE 1 ATOM 2844 N NZ . LYS A 1 378 ? 35.511 -6.661 -14.763 1.00 19.59 ? 434 LYS B NZ 1 ATOM 2845 N N . LEU A 1 379 ? 29.635 -12.438 -15.952 1.00 11.75 ? 435 LEU B N 1 ATOM 2846 C CA . LEU A 1 379 ? 28.228 -12.664 -15.666 1.00 10.83 ? 435 LEU B CA 1 ATOM 2847 C C . LEU A 1 379 ? 28.086 -12.838 -14.148 1.00 13.03 ? 435 LEU B C 1 ATOM 2848 O O . LEU A 1 379 ? 28.534 -13.839 -13.591 1.00 14.48 ? 435 LEU B O 1 ATOM 2849 C CB . LEU A 1 379 ? 27.744 -13.904 -16.424 1.00 3.78 ? 435 LEU B CB 1 ATOM 2850 C CG . LEU A 1 379 ? 26.335 -14.405 -16.129 1.00 9.08 ? 435 LEU B CG 1 ATOM 2851 C CD1 . LEU A 1 379 ? 25.342 -13.312 -16.441 1.00 5.87 ? 435 LEU B CD1 1 ATOM 2852 C CD2 . LEU A 1 379 ? 26.011 -15.690 -16.881 1.00 3.73 ? 435 LEU B CD2 1 ATOM 2853 N N . LEU A 1 380 ? 27.494 -11.851 -13.477 1.00 11.29 ? 436 LEU B N 1 ATOM 2854 C CA . LEU A 1 380 ? 27.367 -11.911 -12.028 1.00 3.14 ? 436 LEU B CA 1 ATOM 2855 C C . LEU A 1 380 ? 25.904 -11.834 -11.647 1.00 5.77 ? 436 LEU B C 1 ATOM 2856 O O . LEU A 1 380 ? 25.304 -10.757 -11.655 1.00 6.38 ? 436 LEU B O 1 ATOM 2857 C CB . LEU A 1 380 ? 28.116 -10.732 -11.419 1.00 3.12 ? 436 LEU B CB 1 ATOM 2858 C CG . LEU A 1 380 ? 29.515 -10.592 -12.026 1.00 3.46 ? 436 LEU B CG 1 ATOM 2859 C CD1 . LEU A 1 380 ? 30.068 -9.168 -11.931 1.00 3.41 ? 436 LEU B CD1 1 ATOM 2860 C CD2 . LEU A 1 380 ? 30.442 -11.584 -11.381 1.00 3.80 ? 436 LEU B CD2 1 ATOM 2861 N N . LEU A 1 381 ? 25.348 -13.000 -11.336 1.00 4.05 ? 437 LEU B N 1 ATOM 2862 C CA . LEU A 1 381 ? 23.947 -13.179 -10.966 1.00 2.54 ? 437 LEU B CA 1 ATOM 2863 C C . LEU A 1 381 ? 23.752 -13.487 -9.490 1.00 17.67 ? 437 LEU B C 1 ATOM 2864 O O . LEU A 1 381 ? 22.674 -13.933 -9.092 1.00 2.32 ? 437 LEU B O 1 ATOM 2865 C CB . LEU A 1 381 ? 23.269 -14.219 -11.871 1.00 17.89 ? 437 LEU B CB 1 ATOM 2866 C CG . LEU A 1 381 ? 23.317 -13.878 -13.370 1.00 11.97 ? 437 LEU B CG 1 ATOM 2867 C CD1 . LEU A 1 381 ? 22.823 -15.028 -14.196 1.00 14.94 ? 437 LEU B CD1 1 ATOM 2868 C CD2 . LEU A 1 381 ? 22.506 -12.639 -13.663 1.00 2.31 ? 437 LEU B CD2 1 ATOM 2869 N N . LEU A 1 382 ? 24.826 -13.366 -8.705 1.00 16.87 ? 438 LEU B N 1 ATOM 2870 C CA . LEU A 1 382 ? 24.820 -13.829 -7.317 1.00 10.55 ? 438 LEU B CA 1 ATOM 2871 C C . LEU A 1 382 ? 23.715 -13.224 -6.470 1.00 15.03 ? 438 LEU B C 1 ATOM 2872 O O . LEU A 1 382 ? 23.303 -12.084 -6.681 1.00 2.12 ? 438 LEU B O 1 ATOM 2873 C CB . LEU A 1 382 ? 26.187 -13.657 -6.631 1.00 6.10 ? 438 LEU B CB 1 ATOM 2874 C CG . LEU A 1 382 ? 26.785 -12.306 -6.203 1.00 4.65 ? 438 LEU B CG 1 ATOM 2875 C CD1 . LEU A 1 382 ? 26.182 -11.744 -4.930 1.00 2.64 ? 438 LEU B CD1 1 ATOM 2876 C CD2 . LEU A 1 382 ? 28.295 -12.418 -6.052 1.00 4.09 ? 438 LEU B CD2 1 ATOM 2877 N N . SER A 1 383 ? 23.238 -14.016 -5.514 1.00 16.89 ? 439 SER B N 1 ATOM 2878 C CA . SER A 1 383 ? 22.214 -13.572 -4.577 1.00 12.23 ? 439 SER B CA 1 ATOM 2879 C C . SER A 1 383 ? 20.922 -13.116 -5.270 1.00 7.30 ? 439 SER B C 1 ATOM 2880 O O . SER A 1 383 ? 20.642 -11.928 -5.393 1.00 9.67 ? 439 SER B O 1 ATOM 2881 C CB . SER A 1 383 ? 22.755 -12.511 -3.616 1.00 9.55 ? 439 SER B CB 1 ATOM 2882 O OG . SER A 1 383 ? 21.749 -12.096 -2.712 1.00 19.62 ? 439 SER B OG 1 ATOM 2883 N N . ASN A 1 384 ? 20.171 -14.086 -5.760 1.00 2.33 ? 440 ASN B N 1 ATOM 2884 C CA . ASN A 1 384 ? 18.829 -13.864 -6.236 1.00 2.00 ? 440 ASN B CA 1 ATOM 2885 C C . ASN A 1 384 ? 18.029 -15.094 -5.865 1.00 4.11 ? 440 ASN B C 1 ATOM 2886 O O . ASN A 1 384 ? 18.463 -15.919 -5.048 1.00 2.83 ? 440 ASN B O 1 ATOM 2887 C CB . ASN A 1 384 ? 18.790 -13.683 -7.763 1.00 5.07 ? 440 ASN B CB 1 ATOM 2888 C CG . ASN A 1 384 ? 19.190 -12.285 -8.210 1.00 9.03 ? 440 ASN B CG 1 ATOM 2889 O OD1 . ASN A 1 384 ? 18.349 -11.407 -8.329 1.00 2.00 ? 440 ASN B OD1 1 ATOM 2890 N ND2 . ASN A 1 384 ? 20.468 -12.088 -8.487 1.00 2.00 ? 440 ASN B ND2 1 ATOM 2891 N N . ASP A 1 385 ? 16.840 -15.172 -6.444 1.00 5.45 ? 441 ASP B N 1 ATOM 2892 C CA . ASP A 1 385 ? 15.934 -16.317 -6.360 1.00 6.30 ? 441 ASP B CA 1 ATOM 2893 C C . ASP A 1 385 ? 16.000 -17.292 -7.563 1.00 14.56 ? 441 ASP B C 1 ATOM 2894 O O . ASP A 1 385 ? 15.008 -17.960 -7.881 1.00 8.79 ? 441 ASP B O 1 ATOM 2895 C CB . ASP A 1 385 ? 14.506 -15.880 -6.042 1.00 17.87 ? 441 ASP B CB 1 ATOM 2896 C CG . ASP A 1 385 ? 13.667 -17.013 -5.497 1.00 26.44 ? 441 ASP B CG 1 ATOM 2897 O OD1 . ASP A 1 385 ? 14.265 -18.014 -5.044 1.00 29.72 ? 441 ASP B OD1 1 ATOM 2898 O OD2 . ASP A 1 385 ? 12.421 -16.904 -5.530 1.00 27.75 ? 441 ASP B OD2 1 ATOM 2899 N N . LEU A 1 386 ? 17.088 -17.237 -8.327 1.00 2.00 ? 442 LEU B N 1 ATOM 2900 C CA . LEU A 1 386 ? 17.231 -18.064 -9.530 1.00 12.50 ? 442 LEU B CA 1 ATOM 2901 C C . LEU A 1 386 ? 17.086 -19.585 -9.347 1.00 13.29 ? 442 LEU B C 1 ATOM 2902 O O . LEU A 1 386 ? 17.696 -20.168 -8.464 1.00 22.54 ? 442 LEU B O 1 ATOM 2903 C CB . LEU A 1 386 ? 18.558 -17.754 -10.227 1.00 12.51 ? 442 LEU B CB 1 ATOM 2904 C CG . LEU A 1 386 ? 18.677 -16.327 -10.760 1.00 4.01 ? 442 LEU B CG 1 ATOM 2905 C CD1 . LEU A 1 386 ? 20.033 -16.100 -11.394 1.00 11.11 ? 442 LEU B CD1 1 ATOM 2906 C CD2 . LEU A 1 386 ? 17.544 -16.035 -11.743 1.00 2.00 ? 442 LEU B CD2 1 ATOM 2907 N N . SER A 1 387 ? 16.290 -20.209 -10.217 1.00 12.81 ? 443 SER B N 1 ATOM 2908 C CA . SER A 1 387 ? 16.059 -21.655 -10.214 1.00 12.64 ? 443 SER B CA 1 ATOM 2909 C C . SER A 1 387 ? 16.382 -22.256 -11.590 1.00 12.66 ? 443 SER B C 1 ATOM 2910 O O . SER A 1 387 ? 16.795 -21.539 -12.491 1.00 10.71 ? 443 SER B O 1 ATOM 2911 C CB . SER A 1 387 ? 14.608 -21.953 -9.844 1.00 2.38 ? 443 SER B CB 1 ATOM 2912 O OG . SER A 1 387 ? 13.755 -20.895 -10.260 1.00 15.06 ? 443 SER B OG 1 ATOM 2913 N N . GLY A 1 388 ? 16.184 -23.565 -11.748 1.00 3.07 ? 444 GLY B N 1 ATOM 2914 C CA . GLY A 1 388 ? 16.479 -24.248 -12.995 1.00 13.34 ? 444 GLY B CA 1 ATOM 2915 C C . GLY A 1 388 ? 17.864 -24.877 -13.079 1.00 19.46 ? 444 GLY B C 1 ATOM 2916 O O . GLY A 1 388 ? 18.619 -24.870 -12.097 1.00 31.89 ? 444 GLY B O 1 ATOM 2917 N N . PHE A 1 389 ? 18.174 -25.472 -14.234 1.00 11.57 ? 445 PHE B N 1 ATOM 2918 C CA . PHE A 1 389 ? 19.522 -25.949 -14.543 1.00 4.33 ? 445 PHE B CA 1 ATOM 2919 C C . PHE A 1 389 ? 20.400 -24.826 -15.055 1.00 7.48 ? 445 PHE B C 1 ATOM 2920 O O . PHE A 1 389 ? 19.915 -23.848 -15.613 1.00 4.03 ? 445 PHE B O 1 ATOM 2921 C CB . PHE A 1 389 ? 19.505 -27.001 -15.638 1.00 4.68 ? 445 PHE B CB 1 ATOM 2922 C CG . PHE A 1 389 ? 18.776 -28.251 -15.284 1.00 25.89 ? 445 PHE B CG 1 ATOM 2923 C CD1 . PHE A 1 389 ? 18.903 -28.821 -14.022 1.00 28.14 ? 445 PHE B CD1 1 ATOM 2924 C CD2 . PHE A 1 389 ? 17.974 -28.872 -16.223 1.00 4.97 ? 445 PHE B CD2 1 ATOM 2925 C CE1 . PHE A 1 389 ? 18.233 -29.993 -13.709 1.00 29.42 ? 445 PHE B CE1 1 ATOM 2926 C CE2 . PHE A 1 389 ? 17.310 -30.020 -15.925 1.00 5.13 ? 445 PHE B CE2 1 ATOM 2927 C CZ . PHE A 1 389 ? 17.433 -30.590 -14.670 1.00 37.97 ? 445 PHE B CZ 1 ATOM 2928 N N . ILE A 1 390 ? 21.704 -24.980 -14.875 1.00 10.83 ? 446 ILE B N 1 ATOM 2929 C CA . ILE A 1 390 ? 22.661 -24.198 -15.640 1.00 13.65 ? 446 ILE B CA 1 ATOM 2930 C C . ILE A 1 390 ? 22.640 -24.769 -17.035 1.00 26.13 ? 446 ILE B C 1 ATOM 2931 O O . ILE A 1 390 ? 22.886 -25.966 -17.225 1.00 30.06 ? 446 ILE B O 1 ATOM 2932 C CB . ILE A 1 390 ? 24.077 -24.346 -15.092 1.00 10.87 ? 446 ILE B CB 1 ATOM 2933 C CG1 . ILE A 1 390 ? 24.221 -23.538 -13.796 1.00 9.17 ? 446 ILE B CG1 1 ATOM 2934 C CG2 . ILE A 1 390 ? 25.086 -23.891 -16.124 1.00 5.04 ? 446 ILE B CG2 1 ATOM 2935 C CD1 . ILE A 1 390 ? 25.410 -23.950 -12.965 1.00 4.82 ? 446 ILE B CD1 1 ATOM 2936 N N . PRO A 1 391 ? 22.330 -23.923 -18.025 1.00 28.26 ? 447 PRO B N 1 ATOM 2937 C CA . PRO A 1 391 ? 22.205 -24.389 -19.410 1.00 17.84 ? 447 PRO B CA 1 ATOM 2938 C C . PRO A 1 391 ? 23.507 -25.018 -19.864 1.00 15.99 ? 447 PRO B C 1 ATOM 2939 O O . PRO A 1 391 ? 24.567 -24.597 -19.397 1.00 11.70 ? 447 PRO B O 1 ATOM 2940 C CB . PRO A 1 391 ? 21.946 -23.100 -20.189 1.00 4.69 ? 447 PRO B CB 1 ATOM 2941 C CG . PRO A 1 391 ? 21.412 -22.136 -19.182 1.00 29.36 ? 447 PRO B CG 1 ATOM 2942 C CD . PRO A 1 391 ? 22.108 -22.473 -17.901 1.00 27.03 ? 447 PRO B CD 1 ATOM 2943 N N . PRO A 1 392 ? 23.429 -26.034 -20.742 1.00 16.33 ? 448 PRO B N 1 ATOM 2944 C CA . PRO A 1 392 ? 24.607 -26.620 -21.397 1.00 10.76 ? 448 PRO B CA 1 ATOM 2945 C C . PRO A 1 392 ? 25.237 -25.622 -22.345 1.00 15.47 ? 448 PRO B C 1 ATOM 2946 O O . PRO A 1 392 ? 26.426 -25.702 -22.630 1.00 6.50 ? 448 PRO B O 1 ATOM 2947 C CB . PRO A 1 392 ? 24.034 -27.800 -22.177 1.00 6.47 ? 448 PRO B CB 1 ATOM 2948 C CG . PRO A 1 392 ? 22.568 -27.528 -22.276 1.00 20.87 ? 448 PRO B CG 1 ATOM 2949 C CD . PRO A 1 392 ? 22.193 -26.764 -21.061 1.00 17.78 ? 448 PRO B CD 1 ATOM 2950 N N . ASP A 1 393 ? 24.456 -24.644 -22.783 1.00 5.84 ? 449 ASP B N 1 ATOM 2951 C CA . ASP A 1 393 ? 24.966 -23.639 -23.707 1.00 17.02 ? 449 ASP B CA 1 ATOM 2952 C C . ASP A 1 393 ? 26.082 -22.808 -23.093 1.00 16.07 ? 449 ASP B C 1 ATOM 2953 O O . ASP A 1 393 ? 26.661 -21.955 -23.753 1.00 16.84 ? 449 ASP B O 1 ATOM 2954 C CB . ASP A 1 393 ? 23.841 -22.733 -24.193 1.00 20.81 ? 449 ASP B CB 1 ATOM 2955 C CG . ASP A 1 393 ? 22.617 -23.517 -24.604 1.00 28.51 ? 449 ASP B CG 1 ATOM 2956 O OD1 . ASP A 1 393 ? 22.222 -24.434 -23.849 1.00 21.17 ? 449 ASP B OD1 1 ATOM 2957 O OD2 . ASP A 1 393 ? 22.062 -23.226 -25.683 1.00 38.04 ? 449 ASP B OD2 1 ATOM 2958 N N . ILE A 1 394 ? 26.352 -23.040 -21.815 1.00 20.21 ? 450 ILE B N 1 ATOM 2959 C CA . ILE A 1 394 ? 27.378 -22.304 -21.087 1.00 20.45 ? 450 ILE B CA 1 ATOM 2960 C C . ILE A 1 394 ? 28.766 -22.424 -21.748 1.00 20.93 ? 450 ILE B C 1 ATOM 2961 O O . ILE A 1 394 ? 29.594 -21.529 -21.616 1.00 28.89 ? 450 ILE B O 1 ATOM 2962 C CB . ILE A 1 394 ? 27.383 -22.711 -19.582 1.00 23.23 ? 450 ILE B CB 1 ATOM 2963 C CG1 . ILE A 1 394 ? 28.311 -21.815 -18.763 1.00 24.59 ? 450 ILE B CG1 1 ATOM 2964 C CG2 . ILE A 1 394 ? 27.716 -24.192 -19.402 1.00 21.94 ? 450 ILE B CG2 1 ATOM 2965 C CD1 . ILE A 1 394 ? 28.373 -22.183 -17.308 1.00 19.59 ? 450 ILE B CD1 1 ATOM 2966 N N . GLY A 1 395 ? 29.006 -23.507 -22.486 1.00 14.35 ? 451 GLY B N 1 ATOM 2967 C CA . GLY A 1 395 ? 30.256 -23.660 -23.219 1.00 14.52 ? 451 GLY B CA 1 ATOM 2968 C C . GLY A 1 395 ? 30.364 -22.786 -24.474 1.00 18.81 ? 451 GLY B C 1 ATOM 2969 O O . GLY A 1 395 ? 31.468 -22.495 -24.947 1.00 21.23 ? 451 GLY B O 1 ATOM 2970 N N . ASN A 1 396 ? 29.216 -22.379 -25.020 1.00 13.72 ? 452 ASN B N 1 ATOM 2971 C CA . ASN A 1 396 ? 29.158 -21.409 -26.113 1.00 13.65 ? 452 ASN B CA 1 ATOM 2972 C C . ASN A 1 396 ? 29.736 -20.029 -25.753 1.00 30.19 ? 452 ASN B C 1 ATOM 2973 O O . ASN A 1 396 ? 29.950 -19.203 -26.642 1.00 32.32 ? 452 ASN B O 1 ATOM 2974 C CB . ASN A 1 396 ? 27.707 -21.180 -26.565 1.00 12.66 ? 452 ASN B CB 1 ATOM 2975 C CG . ASN A 1 396 ? 27.068 -22.404 -27.223 1.00 14.66 ? 452 ASN B CG 1 ATOM 2976 O OD1 . ASN A 1 396 ? 27.439 -23.549 -26.954 1.00 14.19 ? 452 ASN B OD1 1 ATOM 2977 N ND2 . ASN A 1 396 ? 26.083 -22.145 -28.095 1.00 16.39 ? 452 ASN B ND2 1 ATOM 2978 N N . CYS A 1 397 ? 29.959 -19.765 -24.461 1.00 38.72 ? 453 CYS B N 1 ATOM 2979 C CA . CYS A 1 397 ? 30.350 -18.423 -24.018 1.00 33.41 ? 453 CYS B CA 1 ATOM 2980 C C . CYS A 1 397 ? 31.876 -18.384 -23.964 1.00 30.58 ? 453 CYS B C 1 ATOM 2981 O O . CYS A 1 397 ? 32.476 -18.756 -22.963 1.00 22.64 ? 453 CYS B O 1 ATOM 2982 C CB . CYS A 1 397 ? 29.774 -18.208 -22.608 1.00 5.62 ? 453 CYS B CB 1 ATOM 2983 S SG . CYS A 1 397 ? 29.369 -16.518 -22.095 1.00 31.10 ? 453 CYS B SG 1 ATOM 2984 N N . THR A 1 398 ? 32.499 -17.814 -24.991 1.00 41.77 ? 454 THR B N 1 ATOM 2985 C CA . THR A 1 398 ? 33.910 -18.118 -25.257 1.00 41.15 ? 454 THR B CA 1 ATOM 2986 C C . THR A 1 398 ? 34.824 -17.326 -24.357 1.00 32.09 ? 454 THR B C 1 ATOM 2987 O O . THR A 1 398 ? 35.893 -17.798 -23.974 1.00 31.33 ? 454 THR B O 1 ATOM 2988 C CB . THR A 1 398 ? 34.326 -17.843 -26.738 1.00 10.90 ? 454 THR B CB 1 ATOM 2989 O OG1 . THR A 1 398 ? 33.175 -17.510 -27.519 1.00 13.19 ? 454 THR B OG1 1 ATOM 2990 C CG2 . THR A 1 398 ? 35.007 -19.058 -27.340 1.00 7.93 ? 454 THR B CG2 1 ATOM 2991 N N . ASN A 1 399 ? 34.413 -16.096 -24.076 1.00 24.51 ? 455 ASN B N 1 ATOM 2992 C CA . ASN A 1 399 ? 35.240 -15.160 -23.334 1.00 20.58 ? 455 ASN B CA 1 ATOM 2993 C C . ASN A 1 399 ? 34.910 -15.034 -21.856 1.00 16.31 ? 455 ASN B C 1 ATOM 2994 O O . ASN A 1 399 ? 35.456 -14.161 -21.192 1.00 18.16 ? 455 ASN B O 1 ATOM 2995 C CB . ASN A 1 399 ? 35.260 -13.785 -24.006 1.00 21.49 ? 455 ASN B CB 1 ATOM 2996 C CG . ASN A 1 399 ? 36.073 -13.775 -25.291 1.00 21.33 ? 455 ASN B CG 1 ATOM 2997 O OD1 . ASN A 1 399 ? 37.300 -13.786 -25.266 1.00 28.58 ? 455 ASN B OD1 1 ATOM 2998 N ND2 . ASN A 1 399 ? 35.388 -13.746 -26.418 1.00 26.29 ? 455 ASN B ND2 1 ATOM 2999 N N . LEU A 1 400 ? 33.991 -15.862 -21.359 1.00 11.14 ? 456 LEU B N 1 ATOM 3000 C CA . LEU A 1 400 ? 33.608 -15.808 -19.954 1.00 10.57 ? 456 LEU B CA 1 ATOM 3001 C C . LEU A 1 400 ? 34.843 -15.961 -19.089 1.00 18.38 ? 456 LEU B C 1 ATOM 3002 O O . LEU A 1 400 ? 35.598 -16.914 -19.219 1.00 18.57 ? 456 LEU B O 1 ATOM 3003 C CB . LEU A 1 400 ? 32.583 -16.894 -19.615 1.00 5.81 ? 456 LEU B CB 1 ATOM 3004 C CG . LEU A 1 400 ? 31.732 -16.756 -18.346 1.00 5.42 ? 456 LEU B CG 1 ATOM 3005 C CD1 . LEU A 1 400 ? 30.981 -15.450 -18.320 1.00 4.99 ? 456 LEU B CD1 1 ATOM 3006 C CD2 . LEU A 1 400 ? 30.764 -17.917 -18.246 1.00 5.37 ? 456 LEU B CD2 1 ATOM 3007 N N . TYR A 1 401 ? 35.027 -14.995 -18.204 1.00 26.55 ? 457 TYR B N 1 ATOM 3008 C CA . TYR A 1 401 ? 36.198 -14.905 -17.344 1.00 22.32 ? 457 TYR B CA 1 ATOM 3009 C C . TYR A 1 401 ? 35.781 -15.071 -15.879 1.00 19.94 ? 457 TYR B C 1 ATOM 3010 O O . TYR A 1 401 ? 36.298 -15.928 -15.156 1.00 13.70 ? 457 TYR B O 1 ATOM 3011 C CB . TYR A 1 401 ? 36.890 -13.562 -17.548 1.00 9.70 ? 457 TYR B CB 1 ATOM 3012 C CG . TYR A 1 401 ? 38.256 -13.466 -16.906 1.00 15.22 ? 457 TYR B CG 1 ATOM 3013 C CD1 . TYR A 1 401 ? 39.347 -14.102 -17.474 1.00 7.30 ? 457 TYR B CD1 1 ATOM 3014 C CD2 . TYR A 1 401 ? 38.460 -12.726 -15.746 1.00 11.63 ? 457 TYR B CD2 1 ATOM 3015 C CE1 . TYR A 1 401 ? 40.594 -14.015 -16.919 1.00 16.31 ? 457 TYR B CE1 1 ATOM 3016 C CE2 . TYR A 1 401 ? 39.718 -12.631 -15.179 1.00 12.68 ? 457 TYR B CE2 1 ATOM 3017 C CZ . TYR A 1 401 ? 40.778 -13.285 -15.770 1.00 20.67 ? 457 TYR B CZ 1 ATOM 3018 O OH . TYR A 1 401 ? 42.038 -13.215 -15.229 1.00 31.71 ? 457 TYR B OH 1 ATOM 3019 N N . ARG A 1 402 ? 34.888 -14.184 -15.448 1.00 12.86 ? 458 ARG B N 1 ATOM 3020 C CA . ARG A 1 402 ? 34.378 -14.174 -14.092 1.00 5.40 ? 458 ARG B CA 1 ATOM 3021 C C . ARG A 1 402 ? 32.919 -14.590 -14.063 1.00 8.14 ? 458 ARG B C 1 ATOM 3022 O O . ARG A 1 402 ? 32.044 -13.841 -14.486 1.00 8.26 ? 458 ARG B O 1 ATOM 3023 C CB . ARG A 1 402 ? 34.526 -12.772 -13.499 1.00 12.23 ? 458 ARG B CB 1 ATOM 3024 C CG . ARG A 1 402 ? 34.203 -12.671 -12.021 1.00 15.54 ? 458 ARG B CG 1 ATOM 3025 C CD . ARG A 1 402 ? 34.914 -11.482 -11.432 1.00 21.34 ? 458 ARG B CD 1 ATOM 3026 N NE . ARG A 1 402 ? 34.421 -11.129 -10.108 1.00 21.57 ? 458 ARG B NE 1 ATOM 3027 C CZ . ARG A 1 402 ? 34.901 -11.636 -8.979 1.00 16.46 ? 458 ARG B CZ 1 ATOM 3028 N NH1 . ARG A 1 402 ? 34.400 -11.257 -7.807 1.00 14.19 ? 458 ARG B NH1 1 ATOM 3029 N NH2 . ARG A 1 402 ? 35.879 -12.529 -9.023 1.00 13.40 ? 458 ARG B NH2 1 ATOM 3030 N N . LEU A 1 403 ? 32.654 -15.773 -13.529 1.00 5.12 ? 459 LEU B N 1 ATOM 3031 C CA . LEU A 1 403 ? 31.291 -16.263 -13.456 1.00 13.21 ? 459 LEU B CA 1 ATOM 3032 C C . LEU A 1 403 ? 30.856 -16.511 -12.001 1.00 12.60 ? 459 LEU B C 1 ATOM 3033 O O . LEU A 1 403 ? 31.442 -17.341 -11.310 1.00 13.96 ? 459 LEU B O 1 ATOM 3034 C CB . LEU A 1 403 ? 31.169 -17.542 -14.276 1.00 11.49 ? 459 LEU B CB 1 ATOM 3035 C CG . LEU A 1 403 ? 29.796 -18.190 -14.208 1.00 16.11 ? 459 LEU B CG 1 ATOM 3036 C CD1 . LEU A 1 403 ? 28.792 -17.340 -14.968 1.00 21.36 ? 459 LEU B CD1 1 ATOM 3037 C CD2 . LEU A 1 403 ? 29.853 -19.609 -14.727 1.00 5.14 ? 459 LEU B CD2 1 ATOM 3038 N N . ARG A 1 404 ? 29.846 -15.781 -11.526 1.00 12.55 ? 460 ARG B N 1 ATOM 3039 C CA . ARG A 1 404 ? 29.328 -16.018 -10.171 1.00 9.65 ? 460 ARG B CA 1 ATOM 3040 C C . ARG A 1 404 ? 27.811 -16.213 -10.149 1.00 7.22 ? 460 ARG B C 1 ATOM 3041 O O . ARG A 1 404 ? 27.037 -15.285 -10.414 1.00 6.12 ? 460 ARG B O 1 ATOM 3042 C CB . ARG A 1 404 ? 29.716 -14.869 -9.238 1.00 11.16 ? 460 ARG B CB 1 ATOM 3043 C CG . ARG A 1 404 ? 31.142 -14.390 -9.419 1.00 12.12 ? 460 ARG B CG 1 ATOM 3044 C CD . ARG A 1 404 ? 31.553 -13.569 -8.241 1.00 4.22 ? 460 ARG B CD 1 ATOM 3045 N NE . ARG A 1 404 ? 31.359 -14.368 -7.039 1.00 23.05 ? 460 ARG B NE 1 ATOM 3046 C CZ . ARG A 1 404 ? 31.379 -13.901 -5.799 1.00 14.72 ? 460 ARG B CZ 1 ATOM 3047 N NH1 . ARG A 1 404 ? 31.585 -12.609 -5.561 1.00 4.03 ? 460 ARG B NH1 1 ATOM 3048 N NH2 . ARG A 1 404 ? 31.183 -14.746 -4.799 1.00 9.54 ? 460 ARG B NH2 1 ATOM 3049 N N . LEU A 1 405 ? 27.398 -17.444 -9.884 1.00 3.87 ? 461 LEU B N 1 ATOM 3050 C CA . LEU A 1 405 ? 25.984 -17.792 -9.823 1.00 7.80 ? 461 LEU B CA 1 ATOM 3051 C C . LEU A 1 405 ? 25.498 -18.013 -8.408 1.00 8.62 ? 461 LEU B C 1 ATOM 3052 O O . LEU A 1 405 ? 24.361 -18.420 -8.181 1.00 15.51 ? 461 LEU B O 1 ATOM 3053 C CB . LEU A 1 405 ? 25.675 -18.982 -10.738 1.00 19.00 ? 461 LEU B CB 1 ATOM 3054 C CG . LEU A 1 405 ? 26.051 -18.745 -12.203 1.00 3.92 ? 461 LEU B CG 1 ATOM 3055 C CD1 . LEU A 1 405 ? 25.640 -19.920 -13.000 1.00 4.10 ? 461 LEU B CD1 1 ATOM 3056 C CD2 . LEU A 1 405 ? 25.362 -17.514 -12.712 1.00 3.60 ? 461 LEU B CD2 1 ATOM 3057 N N . ASN A 1 406 ? 26.396 -17.778 -7.464 1.00 7.74 ? 462 ASN B N 1 ATOM 3058 C CA . ASN A 1 406 ? 26.204 -18.176 -6.077 1.00 12.50 ? 462 ASN B CA 1 ATOM 3059 C C . ASN A 1 406 ? 25.043 -17.494 -5.345 1.00 13.97 ? 462 ASN B C 1 ATOM 3060 O O . ASN A 1 406 ? 24.690 -16.352 -5.627 1.00 11.22 ? 462 ASN B O 1 ATOM 3061 C CB . ASN A 1 406 ? 27.516 -18.015 -5.309 1.00 3.78 ? 462 ASN B CB 1 ATOM 3062 C CG . ASN A 1 406 ? 27.971 -16.582 -5.234 1.00 15.23 ? 462 ASN B CG 1 ATOM 3063 O OD1 . ASN A 1 406 ? 28.482 -16.034 -6.202 1.00 21.51 ? 462 ASN B OD1 1 ATOM 3064 N ND2 . ASN A 1 406 ? 27.793 -15.963 -4.074 1.00 17.67 ? 462 ASN B ND2 1 ATOM 3065 N N . GLY A 1 407 ? 24.455 -18.207 -4.391 1.00 18.66 ? 463 GLY B N 1 ATOM 3066 C CA . GLY A 1 407 ? 23.322 -17.686 -3.663 1.00 2.80 ? 463 GLY B CA 1 ATOM 3067 C C . GLY A 1 407 ? 22.049 -17.660 -4.475 1.00 2.57 ? 463 GLY B C 1 ATOM 3068 O O . GLY A 1 407 ? 21.387 -16.630 -4.596 1.00 2.45 ? 463 GLY B O 1 ATOM 3069 N N . ASN A 1 408 ? 21.706 -18.807 -5.037 1.00 2.70 ? 464 ASN B N 1 ATOM 3070 C CA . ASN A 1 408 ? 20.460 -18.973 -5.768 1.00 2.53 ? 464 ASN B CA 1 ATOM 3071 C C . ASN A 1 408 ? 19.944 -20.372 -5.473 1.00 7.79 ? 464 ASN B C 1 ATOM 3072 O O . ASN A 1 408 ? 20.445 -21.054 -4.583 1.00 10.96 ? 464 ASN B O 1 ATOM 3073 C CB . ASN A 1 408 ? 20.684 -18.817 -7.277 1.00 7.95 ? 464 ASN B CB 1 ATOM 3074 C CG . ASN A 1 408 ? 20.903 -17.363 -7.708 1.00 6.27 ? 464 ASN B CG 1 ATOM 3075 O OD1 . ASN A 1 408 ? 19.971 -16.569 -7.736 1.00 2.16 ? 464 ASN B OD1 1 ATOM 3076 N ND2 . ASN A 1 408 ? 22.129 -17.031 -8.078 1.00 2.63 ? 464 ASN B ND2 1 ATOM 3077 N N . ARG A 1 409 ? 18.911 -20.785 -6.184 1.00 2.58 ? 465 ARG B N 1 ATOM 3078 C CA . ARG A 1 409 ? 18.409 -22.159 -6.114 1.00 2.73 ? 465 ARG B CA 1 ATOM 3079 C C . ARG A 1 409 ? 18.741 -23.153 -7.244 1.00 3.69 ? 465 ARG B C 1 ATOM 3080 O O . ARG A 1 409 ? 18.133 -24.221 -7.285 1.00 13.50 ? 465 ARG B O 1 ATOM 3081 C CB . ARG A 1 409 ? 16.919 -22.182 -5.772 1.00 11.20 ? 465 ARG B CB 1 ATOM 3082 C CG . ARG A 1 409 ? 16.642 -21.793 -4.343 1.00 5.88 ? 465 ARG B CG 1 ATOM 3083 C CD . ARG A 1 409 ? 15.193 -22.001 -3.978 1.00 12.80 ? 465 ARG B CD 1 ATOM 3084 N NE . ARG A 1 409 ? 14.308 -21.102 -4.712 1.00 21.12 ? 465 ARG B NE 1 ATOM 3085 C CZ . ARG A 1 409 ? 13.465 -21.509 -5.655 1.00 31.17 ? 465 ARG B CZ 1 ATOM 3086 N NH1 . ARG A 1 409 ? 13.392 -22.798 -5.956 1.00 31.74 ? 465 ARG B NH1 1 ATOM 3087 N NH2 . ARG A 1 409 ? 12.685 -20.640 -6.286 1.00 32.27 ? 465 ARG B NH2 1 ATOM 3088 N N . LEU A 1 410 ? 19.634 -22.793 -8.171 1.00 12.11 ? 466 LEU B N 1 ATOM 3089 C CA . LEU A 1 410 ? 19.880 -23.582 -9.408 1.00 12.58 ? 466 LEU B CA 1 ATOM 3090 C C . LEU A 1 410 ? 20.047 -25.077 -9.146 1.00 15.32 ? 466 LEU B C 1 ATOM 3091 O O . LEU A 1 410 ? 20.789 -25.477 -8.241 1.00 24.15 ? 466 LEU B O 1 ATOM 3092 C CB . LEU A 1 410 ? 21.162 -23.110 -10.096 1.00 3.62 ? 466 LEU B CB 1 ATOM 3093 C CG . LEU A 1 410 ? 21.332 -21.623 -10.371 1.00 3.39 ? 466 LEU B CG 1 ATOM 3094 C CD1 . LEU A 1 410 ? 22.787 -21.296 -10.640 1.00 3.62 ? 466 LEU B CD1 1 ATOM 3095 C CD2 . LEU A 1 410 ? 20.451 -21.209 -11.518 1.00 3.24 ? 466 LEU B CD2 1 ATOM 3096 N N . ALA A 1 411 ? 19.354 -25.907 -9.925 1.00 10.61 ? 467 ALA B N 1 ATOM 3097 C CA . ALA A 1 411 ? 19.335 -27.341 -9.623 1.00 16.67 ? 467 ALA B CA 1 ATOM 3098 C C . ALA A 1 411 ? 20.158 -28.173 -10.594 1.00 4.54 ? 467 ALA B C 1 ATOM 3099 O O . ALA A 1 411 ? 20.790 -27.627 -11.490 1.00 12.15 ? 467 ALA B O 1 ATOM 3100 C CB . ALA A 1 411 ? 17.923 -27.851 -9.549 1.00 4.03 ? 467 ALA B CB 1 ATOM 3101 N N . GLY A 1 412 ? 20.158 -29.492 -10.396 1.00 6.14 ? 468 GLY B N 1 ATOM 3102 C CA . GLY A 1 412 ? 20.789 -30.417 -11.326 1.00 5.23 ? 468 GLY B CA 1 ATOM 3103 C C . GLY A 1 412 ? 22.303 -30.407 -11.355 1.00 17.39 ? 468 GLY B C 1 ATOM 3104 O O . GLY A 1 412 ? 22.931 -29.681 -10.599 1.00 21.65 ? 468 GLY B O 1 ATOM 3105 N N . SER A 1 413 ? 22.890 -31.222 -12.231 1.00 20.78 ? 469 SER B N 1 ATOM 3106 C CA . SER A 1 413 ? 24.349 -31.318 -12.368 1.00 6.20 ? 469 SER B CA 1 ATOM 3107 C C . SER A 1 413 ? 24.982 -30.126 -13.095 1.00 9.69 ? 469 SER B C 1 ATOM 3108 O O . SER A 1 413 ? 24.298 -29.358 -13.773 1.00 10.16 ? 469 SER B O 1 ATOM 3109 C CB . SER A 1 413 ? 24.741 -32.614 -13.071 1.00 6.68 ? 469 SER B CB 1 ATOM 3110 O OG . SER A 1 413 ? 24.087 -33.720 -12.482 1.00 33.56 ? 469 SER B OG 1 ATOM 3111 N N . ILE A 1 414 ? 26.290 -29.970 -12.913 1.00 12.06 ? 470 ILE B N 1 ATOM 3112 C CA . ILE A 1 414 ? 27.085 -28.986 -13.636 1.00 14.42 ? 470 ILE B CA 1 ATOM 3113 C C . ILE A 1 414 ? 27.456 -29.553 -15.005 1.00 20.27 ? 470 ILE B C 1 ATOM 3114 O O . ILE A 1 414 ? 28.196 -30.551 -15.094 1.00 12.32 ? 470 ILE B O 1 ATOM 3115 C CB . ILE A 1 414 ? 28.386 -28.661 -12.875 1.00 14.93 ? 470 ILE B CB 1 ATOM 3116 C CG1 . ILE A 1 414 ? 28.069 -28.160 -11.461 1.00 12.87 ? 470 ILE B CG1 1 ATOM 3117 C CG2 . ILE A 1 414 ? 29.245 -27.668 -13.663 1.00 9.22 ? 470 ILE B CG2 1 ATOM 3118 C CD1 . ILE A 1 414 ? 29.273 -27.916 -10.612 1.00 6.32 ? 470 ILE B CD1 1 ATOM 3119 N N . PRO A 1 415 ? 26.951 -28.916 -16.083 1.00 20.12 ? 471 PRO B N 1 ATOM 3120 C CA . PRO A 1 415 ? 27.155 -29.402 -17.447 1.00 20.83 ? 471 PRO B CA 1 ATOM 3121 C C . PRO A 1 415 ? 28.629 -29.488 -17.809 1.00 23.34 ? 471 PRO B C 1 ATOM 3122 O O . PRO A 1 415 ? 29.410 -28.585 -17.484 1.00 18.22 ? 471 PRO B O 1 ATOM 3123 C CB . PRO A 1 415 ? 26.471 -28.337 -18.299 1.00 23.55 ? 471 PRO B CB 1 ATOM 3124 C CG . PRO A 1 415 ? 26.475 -27.123 -17.451 1.00 23.73 ? 471 PRO B CG 1 ATOM 3125 C CD . PRO A 1 415 ? 26.264 -27.614 -16.072 1.00 18.58 ? 471 PRO B CD 1 ATOM 3126 N N . SER A 1 416 ? 28.987 -30.564 -18.504 1.00 21.95 ? 472 SER B N 1 ATOM 3127 C CA . SER A 1 416 ? 30.368 -30.864 -18.851 1.00 17.62 ? 472 SER B CA 1 ATOM 3128 C C . SER A 1 416 ? 30.903 -29.909 -19.908 1.00 14.22 ? 472 SER B C 1 ATOM 3129 O O . SER A 1 416 ? 32.071 -29.967 -20.269 1.00 13.91 ? 472 SER B O 1 ATOM 3130 C CB . SER A 1 416 ? 30.475 -32.305 -19.347 1.00 25.15 ? 472 SER B CB 1 ATOM 3131 O OG . SER A 1 416 ? 29.922 -33.209 -18.404 1.00 32.39 ? 472 SER B OG 1 ATOM 3132 N N . GLU A 1 417 ? 30.046 -29.040 -20.426 1.00 7.91 ? 473 GLU B N 1 ATOM 3133 C CA . GLU A 1 417 ? 30.484 -28.105 -21.439 1.00 7.92 ? 473 GLU B CA 1 ATOM 3134 C C . GLU A 1 417 ? 31.309 -26.995 -20.852 1.00 15.27 ? 473 GLU B C 1 ATOM 3135 O O . GLU A 1 417 ? 31.929 -26.247 -21.575 1.00 26.58 ? 473 GLU B O 1 ATOM 3136 C CB . GLU A 1 417 ? 29.295 -27.494 -22.169 1.00 15.58 ? 473 GLU B CB 1 ATOM 3137 C CG . GLU A 1 417 ? 27.972 -28.130 -21.850 1.00 22.90 ? 473 GLU B CG 1 ATOM 3138 C CD . GLU A 1 417 ? 27.751 -29.412 -22.588 1.00 30.48 ? 473 GLU B CD 1 ATOM 3139 O OE1 . GLU A 1 417 ? 28.663 -30.261 -22.594 1.00 35.03 ? 473 GLU B OE1 1 ATOM 3140 O OE2 . GLU A 1 417 ? 26.653 -29.579 -23.148 1.00 38.46 ? 473 GLU B OE2 1 ATOM 3141 N N . ILE A 1 418 ? 31.316 -26.876 -19.534 1.00 19.11 ? 474 ILE B N 1 ATOM 3142 C CA . ILE A 1 418 ? 31.965 -25.743 -18.890 1.00 13.56 ? 474 ILE B CA 1 ATOM 3143 C C . ILE A 1 418 ? 33.477 -25.866 -19.064 1.00 17.38 ? 474 ILE B C 1 ATOM 3144 O O . ILE A 1 418 ? 34.220 -24.894 -18.937 1.00 21.84 ? 474 ILE B O 1 ATOM 3145 C CB . ILE A 1 418 ? 31.542 -25.628 -17.399 1.00 17.85 ? 474 ILE B CB 1 ATOM 3146 C CG1 . ILE A 1 418 ? 31.887 -24.244 -16.845 1.00 17.47 ? 474 ILE B CG1 1 ATOM 3147 C CG2 . ILE A 1 418 ? 32.152 -26.752 -16.560 1.00 16.78 ? 474 ILE B CG2 1 ATOM 3148 C CD1 . ILE A 1 418 ? 31.446 -24.033 -15.438 1.00 12.71 ? 474 ILE B CD1 1 ATOM 3149 N N . GLY A 1 419 ? 33.917 -27.077 -19.384 1.00 23.41 ? 475 GLY B N 1 ATOM 3150 C CA . GLY A 1 419 ? 35.296 -27.325 -19.764 1.00 25.36 ? 475 GLY B CA 1 ATOM 3151 C C . GLY A 1 419 ? 35.639 -26.829 -21.164 1.00 18.24 ? 475 GLY B C 1 ATOM 3152 O O . GLY A 1 419 ? 36.801 -26.868 -21.547 1.00 12.45 ? 475 GLY B O 1 ATOM 3153 N N . ASN A 1 420 ? 34.635 -26.378 -21.922 1.00 8.76 ? 476 ASN B N 1 ATOM 3154 C CA . ASN A 1 420 ? 34.850 -25.683 -23.181 1.00 8.84 ? 476 ASN B CA 1 ATOM 3155 C C . ASN A 1 420 ? 35.469 -24.311 -22.961 1.00 29.48 ? 476 ASN B C 1 ATOM 3156 O O . ASN A 1 420 ? 36.057 -23.730 -23.881 1.00 27.71 ? 476 ASN B O 1 ATOM 3157 C CB . ASN A 1 420 ? 33.523 -25.489 -23.912 1.00 48.85 ? 476 ASN B CB 1 ATOM 3158 C CG . ASN A 1 420 ? 33.538 -26.026 -25.327 1.00 43.17 ? 476 ASN B CG 1 ATOM 3159 O OD1 . ASN A 1 420 ? 34.575 -26.032 -26.000 1.00 32.47 ? 476 ASN B OD1 1 ATOM 3160 N ND2 . ASN A 1 420 ? 32.373 -26.476 -25.793 1.00 45.10 ? 476 ASN B ND2 1 ATOM 3161 N N . LEU A 1 421 ? 35.352 -23.782 -21.745 1.00 17.11 ? 477 LEU B N 1 ATOM 3162 C CA . LEU A 1 421 ? 35.698 -22.376 -21.543 1.00 18.05 ? 477 LEU B CA 1 ATOM 3163 C C . LEU A 1 421 ? 37.156 -22.206 -21.152 1.00 23.80 ? 477 LEU B C 1 ATOM 3164 O O . LEU A 1 421 ? 37.558 -22.499 -20.029 1.00 30.57 ? 477 LEU B O 1 ATOM 3165 C CB . LEU A 1 421 ? 34.791 -21.763 -20.488 1.00 13.79 ? 477 LEU B CB 1 ATOM 3166 C CG . LEU A 1 421 ? 33.315 -21.966 -20.791 1.00 13.08 ? 477 LEU B CG 1 ATOM 3167 C CD1 . LEU A 1 421 ? 32.417 -21.199 -19.825 1.00 17.02 ? 477 LEU B CD1 1 ATOM 3168 C CD2 . LEU A 1 421 ? 33.071 -21.530 -22.200 1.00 11.59 ? 477 LEU B CD2 1 ATOM 3169 N N . LYS A 1 422 ? 37.940 -21.687 -22.090 1.00 26.62 ? 478 LYS B N 1 ATOM 3170 C CA . LYS A 1 422 ? 39.390 -21.689 -21.949 1.00 26.30 ? 478 LYS B CA 1 ATOM 3171 C C . LYS A 1 422 ? 39.925 -20.415 -21.328 1.00 17.85 ? 478 LYS B C 1 ATOM 3172 O O . LYS A 1 422 ? 41.106 -20.336 -20.992 1.00 15.06 ? 478 LYS B O 1 ATOM 3173 C CB . LYS A 1 422 ? 40.037 -21.935 -23.308 1.00 9.81 ? 478 LYS B CB 1 ATOM 3174 C CG . LYS A 1 422 ? 39.382 -23.078 -24.068 1.00 17.79 ? 478 LYS B CG 1 ATOM 3175 C CD . LYS A 1 422 ? 39.838 -24.438 -23.560 1.00 15.14 ? 478 LYS B CD 1 ATOM 3176 C CE . LYS A 1 422 ? 38.938 -25.555 -24.083 1.00 16.28 ? 478 LYS B CE 1 ATOM 3177 N NZ . LYS A 1 422 ? 39.418 -26.914 -23.669 1.00 12.66 ? 478 LYS B NZ 1 ATOM 3178 N N . ASN A 1 423 ? 39.067 -19.408 -21.209 1.00 14.94 ? 479 ASN B N 1 ATOM 3179 C CA . ASN A 1 423 ? 39.453 -18.173 -20.545 1.00 24.80 ? 479 ASN B CA 1 ATOM 3180 C C . ASN A 1 423 ? 38.927 -18.046 -19.107 1.00 28.46 ? 479 ASN B C 1 ATOM 3181 O O . ASN A 1 423 ? 39.177 -17.049 -18.429 1.00 7.85 ? 479 ASN B O 1 ATOM 3182 C CB . ASN A 1 423 ? 39.073 -16.967 -21.407 1.00 27.84 ? 479 ASN B CB 1 ATOM 3183 C CG . ASN A 1 423 ? 39.564 -17.103 -22.843 1.00 32.79 ? 479 ASN B CG 1 ATOM 3184 O OD1 . ASN A 1 423 ? 38.887 -17.696 -23.682 1.00 46.09 ? 479 ASN B OD1 1 ATOM 3185 N ND2 . ASN A 1 423 ? 40.744 -16.563 -23.128 1.00 23.24 ? 479 ASN B ND2 1 ATOM 3186 N N . LEU A 1 424 ? 38.217 -19.064 -18.634 1.00 23.07 ? 480 LEU B N 1 ATOM 3187 C CA . LEU A 1 424 ? 37.441 -18.899 -17.425 1.00 7.48 ? 480 LEU B CA 1 ATOM 3188 C C . LEU A 1 424 ? 38.359 -18.966 -16.213 1.00 24.54 ? 480 LEU B C 1 ATOM 3189 O O . LEU A 1 424 ? 38.916 -20.009 -15.870 1.00 17.09 ? 480 LEU B O 1 ATOM 3190 C CB . LEU A 1 424 ? 36.399 -20.008 -17.364 1.00 7.34 ? 480 LEU B CB 1 ATOM 3191 C CG . LEU A 1 424 ? 35.307 -19.980 -16.295 1.00 7.82 ? 480 LEU B CG 1 ATOM 3192 C CD1 . LEU A 1 424 ? 34.760 -18.571 -16.047 1.00 6.42 ? 480 LEU B CD1 1 ATOM 3193 C CD2 . LEU A 1 424 ? 34.201 -20.910 -16.754 1.00 6.76 ? 480 LEU B CD2 1 ATOM 3194 N N . ASN A 1 425 ? 38.505 -17.820 -15.563 1.00 28.50 ? 481 ASN B N 1 ATOM 3195 C CA . ASN A 1 425 ? 39.365 -17.699 -14.404 1.00 22.98 ? 481 ASN B CA 1 ATOM 3196 C C . ASN A 1 425 ? 38.678 -18.046 -13.101 1.00 19.54 ? 481 ASN B C 1 ATOM 3197 O O . ASN A 1 425 ? 39.258 -18.720 -12.253 1.00 20.99 ? 481 ASN B O 1 ATOM 3198 C CB . ASN A 1 425 ? 39.969 -16.299 -14.323 1.00 21.04 ? 481 ASN B CB 1 ATOM 3199 C CG . ASN A 1 425 ? 40.980 -16.175 -13.213 1.00 30.16 ? 481 ASN B CG 1 ATOM 3200 O OD1 . ASN A 1 425 ? 42.071 -16.733 -13.297 1.00 37.57 ? 481 ASN B OD1 1 ATOM 3201 N ND2 . ASN A 1 425 ? 40.623 -15.448 -12.158 1.00 31.52 ? 481 ASN B ND2 1 ATOM 3202 N N . PHE A 1 426 ? 37.446 -17.561 -12.955 1.00 16.16 ? 482 PHE B N 1 ATOM 3203 C CA . PHE A 1 426 ? 36.770 -17.480 -11.656 1.00 10.89 ? 482 PHE B CA 1 ATOM 3204 C C . PHE A 1 426 ? 35.343 -17.966 -11.770 1.00 9.74 ? 482 PHE B C 1 ATOM 3205 O O . PHE A 1 426 ? 34.509 -17.295 -12.379 1.00 10.08 ? 482 PHE B O 1 ATOM 3206 C CB . PHE A 1 426 ? 36.751 -16.004 -11.230 1.00 9.17 ? 482 PHE B CB 1 ATOM 3207 C CG . PHE A 1 426 ? 36.302 -15.753 -9.814 1.00 10.60 ? 482 PHE B CG 1 ATOM 3208 C CD1 . PHE A 1 426 ? 34.955 -15.702 -9.485 1.00 17.20 ? 482 PHE B CD1 1 ATOM 3209 C CD2 . PHE A 1 426 ? 37.233 -15.507 -8.814 1.00 10.45 ? 482 PHE B CD2 1 ATOM 3210 C CE1 . PHE A 1 426 ? 34.553 -15.442 -8.181 1.00 5.31 ? 482 PHE B CE1 1 ATOM 3211 C CE2 . PHE A 1 426 ? 36.837 -15.243 -7.525 1.00 5.95 ? 482 PHE B CE2 1 ATOM 3212 C CZ . PHE A 1 426 ? 35.494 -15.216 -7.209 1.00 5.52 ? 482 PHE B CZ 1 ATOM 3213 N N . VAL A 1 427 ? 35.027 -19.089 -11.137 1.00 6.21 ? 483 VAL B N 1 ATOM 3214 C CA . VAL A 1 427 ? 33.631 -19.501 -11.066 1.00 15.14 ? 483 VAL B CA 1 ATOM 3215 C C . VAL A 1 427 ? 33.154 -19.701 -9.628 1.00 13.10 ? 483 VAL B C 1 ATOM 3216 O O . VAL A 1 427 ? 33.818 -20.366 -8.832 1.00 16.01 ? 483 VAL B O 1 ATOM 3217 C CB . VAL A 1 427 ? 33.313 -20.711 -11.994 1.00 14.80 ? 483 VAL B CB 1 ATOM 3218 C CG1 . VAL A 1 427 ? 34.535 -21.135 -12.748 1.00 6.55 ? 483 VAL B CG1 1 ATOM 3219 C CG2 . VAL A 1 427 ? 32.709 -21.880 -11.233 1.00 8.92 ? 483 VAL B CG2 1 ATOM 3220 N N . ASP A 1 428 ? 32.026 -19.082 -9.282 1.00 15.80 ? 484 ASP B N 1 ATOM 3221 C CA . ASP A 1 428 ? 31.426 -19.315 -7.970 1.00 12.55 ? 484 ASP B CA 1 ATOM 3222 C C . ASP A 1 428 ? 29.970 -19.704 -8.138 1.00 10.30 ? 484 ASP B C 1 ATOM 3223 O O . ASP A 1 428 ? 29.103 -18.869 -8.418 1.00 5.72 ? 484 ASP B O 1 ATOM 3224 C CB . ASP A 1 428 ? 31.539 -18.047 -7.112 1.00 10.57 ? 484 ASP B CB 1 ATOM 3225 C CG . ASP A 1 428 ? 30.955 -18.214 -5.718 1.00 16.24 ? 484 ASP B CG 1 ATOM 3226 O OD1 . ASP A 1 428 ? 30.562 -19.345 -5.344 1.00 16.97 ? 484 ASP B OD1 1 ATOM 3227 O OD2 . ASP A 1 428 ? 30.901 -17.199 -4.985 1.00 19.85 ? 484 ASP B OD2 1 ATOM 3228 N N . ILE A 1 429 ? 29.736 -20.997 -7.959 1.00 4.90 ? 485 ILE B N 1 ATOM 3229 C CA . ILE A 1 429 ? 28.425 -21.629 -7.919 1.00 4.69 ? 485 ILE B CA 1 ATOM 3230 C C . ILE A 1 429 ? 27.977 -22.027 -6.515 1.00 11.73 ? 485 ILE B C 1 ATOM 3231 O O . ILE A 1 429 ? 27.128 -22.896 -6.362 1.00 4.90 ? 485 ILE B O 1 ATOM 3232 C CB . ILE A 1 429 ? 28.304 -22.807 -8.883 1.00 12.61 ? 485 ILE B CB 1 ATOM 3233 C CG1 . ILE A 1 429 ? 29.394 -22.755 -9.948 1.00 7.42 ? 485 ILE B CG1 1 ATOM 3234 C CG2 . ILE A 1 429 ? 26.942 -22.781 -9.563 1.00 18.86 ? 485 ILE B CG2 1 ATOM 3235 C CD1 . ILE A 1 429 ? 29.337 -23.918 -10.901 1.00 7.03 ? 485 ILE B CD1 1 ATOM 3236 N N . SER A 1 430 ? 28.648 -21.520 -5.493 1.00 4.60 ? 486 SER B N 1 ATOM 3237 C CA . SER A 1 430 ? 28.328 -21.920 -4.129 1.00 8.57 ? 486 SER B CA 1 ATOM 3238 C C . SER A 1 430 ? 26.898 -21.550 -3.750 1.00 9.36 ? 486 SER B C 1 ATOM 3239 O O . SER A 1 430 ? 26.248 -20.784 -4.457 1.00 3.89 ? 486 SER B O 1 ATOM 3240 C CB . SER A 1 430 ? 29.311 -21.318 -3.130 1.00 7.86 ? 486 SER B CB 1 ATOM 3241 O OG . SER A 1 430 ? 29.315 -19.917 -3.218 1.00 9.09 ? 486 SER B OG 1 ATOM 3242 N N . GLU A 1 431 ? 26.396 -22.184 -2.689 1.00 9.75 ? 487 GLU B N 1 ATOM 3243 C CA . GLU A 1 431 ? 25.076 -21.897 -2.119 1.00 3.73 ? 487 GLU B CA 1 ATOM 3244 C C . GLU A 1 431 ? 23.952 -22.056 -3.120 1.00 3.57 ? 487 GLU B C 1 ATOM 3245 O O . GLU A 1 431 ? 23.273 -21.091 -3.473 1.00 7.09 ? 487 GLU B O 1 ATOM 3246 C CB . GLU A 1 431 ? 25.039 -20.511 -1.464 1.00 3.50 ? 487 GLU B CB 1 ATOM 3247 C CG . GLU A 1 431 ? 25.265 -20.529 0.028 1.00 35.14 ? 487 GLU B CG 1 ATOM 3248 C CD . GLU A 1 431 ? 25.565 -19.152 0.585 1.00 32.83 ? 487 GLU B CD 1 ATOM 3249 O OE1 . GLU A 1 431 ? 25.537 -18.987 1.830 1.00 31.51 ? 487 GLU B OE1 1 ATOM 3250 O OE2 . GLU A 1 431 ? 25.841 -18.239 -0.226 1.00 31.80 ? 487 GLU B OE2 1 ATOM 3251 N N . ASN A 1 432 ? 23.767 -23.293 -3.565 1.00 19.04 ? 488 ASN B N 1 ATOM 3252 C CA . ASN A 1 432 ? 22.719 -23.659 -4.526 1.00 18.43 ? 488 ASN B CA 1 ATOM 3253 C C . ASN A 1 432 ? 22.205 -25.066 -4.235 1.00 18.70 ? 488 ASN B C 1 ATOM 3254 O O . ASN A 1 432 ? 22.485 -25.632 -3.178 1.00 21.97 ? 488 ASN B O 1 ATOM 3255 C CB . ASN A 1 432 ? 23.210 -23.570 -5.984 1.00 3.81 ? 488 ASN B CB 1 ATOM 3256 C CG . ASN A 1 432 ? 23.130 -22.159 -6.547 1.00 25.02 ? 488 ASN B CG 1 ATOM 3257 O OD1 . ASN A 1 432 ? 22.056 -21.664 -6.846 1.00 3.31 ? 488 ASN B OD1 1 ATOM 3258 N ND2 . ASN A 1 432 ? 24.269 -21.519 -6.706 1.00 3.70 ? 488 ASN B ND2 1 ATOM 3259 N N . ARG A 1 433 ? 21.410 -25.589 -5.157 1.00 3.80 ? 489 ARG B N 1 ATOM 3260 C CA . ARG A 1 433 ? 20.877 -26.948 -5.096 1.00 3.96 ? 489 ARG B CA 1 ATOM 3261 C C . ARG A 1 433 ? 21.571 -28.016 -5.954 1.00 22.14 ? 489 ARG B C 1 ATOM 3262 O O . ARG A 1 433 ? 21.001 -29.095 -6.142 1.00 26.18 ? 489 ARG B O 1 ATOM 3263 C CB . ARG A 1 433 ? 19.388 -26.940 -5.376 1.00 9.18 ? 489 ARG B CB 1 ATOM 3264 C CG . ARG A 1 433 ? 18.656 -25.932 -4.541 1.00 3.36 ? 489 ARG B CG 1 ATOM 3265 C CD . ARG A 1 433 ? 18.620 -26.319 -3.086 1.00 10.92 ? 489 ARG B CD 1 ATOM 3266 N NE . ARG A 1 433 ? 17.264 -26.096 -2.601 1.00 23.00 ? 489 ARG B NE 1 ATOM 3267 C CZ . ARG A 1 433 ? 16.815 -24.913 -2.198 1.00 26.82 ? 489 ARG B CZ 1 ATOM 3268 N NH1 . ARG A 1 433 ? 17.638 -23.869 -2.204 1.00 30.29 ? 489 ARG B NH1 1 ATOM 3269 N NH2 . ARG A 1 433 ? 15.560 -24.774 -1.781 1.00 18.05 ? 489 ARG B NH2 1 ATOM 3270 N N . LEU A 1 434 ? 22.735 -27.693 -6.529 1.00 19.53 ? 490 LEU B N 1 ATOM 3271 C CA . LEU A 1 434 ? 23.404 -28.535 -7.531 1.00 4.92 ? 490 LEU B CA 1 ATOM 3272 C C . LEU A 1 434 ? 23.574 -29.972 -7.071 1.00 16.39 ? 490 LEU B C 1 ATOM 3273 O O . LEU A 1 434 ? 23.766 -30.222 -5.881 1.00 18.79 ? 490 LEU B O 1 ATOM 3274 C CB . LEU A 1 434 ? 24.800 -28.000 -7.837 1.00 5.11 ? 490 LEU B CB 1 ATOM 3275 C CG . LEU A 1 434 ? 25.013 -26.596 -8.387 1.00 4.91 ? 490 LEU B CG 1 ATOM 3276 C CD1 . LEU A 1 434 ? 26.493 -26.371 -8.562 1.00 5.18 ? 490 LEU B CD1 1 ATOM 3277 C CD2 . LEU A 1 434 ? 24.298 -26.376 -9.701 1.00 4.82 ? 490 LEU B CD2 1 ATOM 3278 N N . VAL A 1 435 ? 23.502 -30.919 -8.010 1.00 15.94 ? 491 VAL B N 1 ATOM 3279 C CA . VAL A 1 435 ? 23.688 -32.337 -7.673 1.00 19.63 ? 491 VAL B CA 1 ATOM 3280 C C . VAL A 1 435 ? 24.707 -33.073 -8.536 1.00 13.94 ? 491 VAL B C 1 ATOM 3281 O O . VAL A 1 435 ? 25.419 -32.471 -9.330 1.00 23.40 ? 491 VAL B O 1 ATOM 3282 C CB . VAL A 1 435 ? 22.366 -33.124 -7.670 1.00 5.78 ? 491 VAL B CB 1 ATOM 3283 C CG1 . VAL A 1 435 ? 21.499 -32.689 -6.516 1.00 5.41 ? 491 VAL B CG1 1 ATOM 3284 C CG2 . VAL A 1 435 ? 21.655 -32.927 -8.971 1.00 6.41 ? 491 VAL B CG2 1 ATOM 3285 N N . GLY A 1 436 ? 24.795 -34.382 -8.332 1.00 11.48 ? 492 GLY B N 1 ATOM 3286 C CA . GLY A 1 436 ? 25.709 -35.222 -9.078 1.00 15.80 ? 492 GLY B CA 1 ATOM 3287 C C . GLY A 1 436 ? 27.175 -34.971 -8.798 1.00 9.49 ? 492 GLY B C 1 ATOM 3288 O O . GLY A 1 436 ? 27.535 -34.165 -7.952 1.00 10.47 ? 492 GLY B O 1 ATOM 3289 N N . SER A 1 437 ? 28.027 -35.679 -9.525 1.00 15.79 ? 493 SER B N 1 ATOM 3290 C CA . SER A 1 437 ? 29.467 -35.526 -9.417 1.00 8.07 ? 493 SER B CA 1 ATOM 3291 C C . SER A 1 437 ? 29.964 -34.245 -10.071 1.00 15.85 ? 493 SER B C 1 ATOM 3292 O O . SER A 1 437 ? 29.273 -33.635 -10.869 1.00 15.83 ? 493 SER B O 1 ATOM 3293 C CB . SER A 1 437 ? 30.145 -36.724 -10.054 1.00 14.30 ? 493 SER B CB 1 ATOM 3294 O OG . SER A 1 437 ? 29.622 -37.920 -9.515 1.00 22.47 ? 493 SER B OG 1 ATOM 3295 N N . ILE A 1 438 ? 31.161 -33.816 -9.703 1.00 23.29 ? 494 ILE B N 1 ATOM 3296 C CA . ILE A 1 438 ? 31.814 -32.731 -10.414 1.00 23.00 ? 494 ILE B CA 1 ATOM 3297 C C . ILE A 1 438 ? 32.355 -33.301 -11.724 1.00 33.02 ? 494 ILE B C 1 ATOM 3298 O O . ILE A 1 438 ? 33.171 -34.232 -11.706 1.00 36.92 ? 494 ILE B O 1 ATOM 3299 C CB . ILE A 1 438 ? 32.959 -32.144 -9.585 1.00 19.45 ? 494 ILE B CB 1 ATOM 3300 C CG1 . ILE A 1 438 ? 32.403 -31.476 -8.319 1.00 23.87 ? 494 ILE B CG1 1 ATOM 3301 C CG2 . ILE A 1 438 ? 33.775 -31.167 -10.420 1.00 15.32 ? 494 ILE B CG2 1 ATOM 3302 C CD1 . ILE A 1 438 ? 33.466 -31.021 -7.339 1.00 27.69 ? 494 ILE B CD1 1 ATOM 3303 N N . PRO A 1 439 ? 31.884 -32.763 -12.866 1.00 31.98 ? 495 PRO B N 1 ATOM 3304 C CA . PRO A 1 439 ? 32.196 -33.299 -14.204 1.00 24.68 ? 495 PRO B CA 1 ATOM 3305 C C . PRO A 1 439 ? 33.681 -33.234 -14.573 1.00 19.92 ? 495 PRO B C 1 ATOM 3306 O O . PRO A 1 439 ? 34.253 -32.140 -14.586 1.00 17.24 ? 495 PRO B O 1 ATOM 3307 C CB . PRO A 1 439 ? 31.402 -32.376 -15.135 1.00 26.34 ? 495 PRO B CB 1 ATOM 3308 C CG . PRO A 1 439 ? 31.242 -31.101 -14.359 1.00 30.77 ? 495 PRO B CG 1 ATOM 3309 C CD . PRO A 1 439 ? 31.073 -31.536 -12.935 1.00 31.09 ? 495 PRO B CD 1 ATOM 3310 N N . PRO A 1 440 ? 34.278 -34.377 -14.956 1.00 9.80 ? 496 PRO B N 1 ATOM 3311 C CA . PRO A 1 440 ? 35.718 -34.447 -15.222 1.00 16.50 ? 496 PRO B CA 1 ATOM 3312 C C . PRO A 1 440 ? 36.139 -33.510 -16.343 1.00 15.06 ? 496 PRO B C 1 ATOM 3313 O O . PRO A 1 440 ? 37.323 -33.208 -16.492 1.00 13.93 ? 496 PRO B O 1 ATOM 3314 C CB . PRO A 1 440 ? 35.928 -35.903 -15.639 1.00 11.02 ? 496 PRO B CB 1 ATOM 3315 C CG . PRO A 1 440 ? 34.801 -36.631 -15.052 1.00 10.71 ? 496 PRO B CG 1 ATOM 3316 C CD . PRO A 1 440 ? 33.641 -35.694 -15.096 1.00 11.72 ? 496 PRO B CD 1 ATOM 3317 N N . ALA A 1 441 ? 35.163 -33.053 -17.118 1.00 17.30 ? 497 ALA B N 1 ATOM 3318 C CA . ALA A 1 441 ? 35.415 -32.183 -18.254 1.00 10.02 ? 497 ALA B CA 1 ATOM 3319 C C . ALA A 1 441 ? 35.961 -30.832 -17.813 1.00 13.85 ? 497 ALA B C 1 ATOM 3320 O O . ALA A 1 441 ? 36.638 -30.155 -18.582 1.00 22.07 ? 497 ALA B O 1 ATOM 3321 C CB . ALA A 1 441 ? 34.149 -32.018 -19.093 1.00 9.69 ? 497 ALA B CB 1 ATOM 3322 N N . ILE A 1 442 ? 35.693 -30.446 -16.569 1.00 17.44 ? 498 ILE B N 1 ATOM 3323 C CA . ILE A 1 442 ? 36.218 -29.185 -16.046 1.00 19.44 ? 498 ILE B CA 1 ATOM 3324 C C . ILE A 1 442 ? 37.748 -29.168 -16.063 1.00 25.03 ? 498 ILE B C 1 ATOM 3325 O O . ILE A 1 442 ? 38.368 -28.108 -16.009 1.00 31.21 ? 498 ILE B O 1 ATOM 3326 C CB . ILE A 1 442 ? 35.699 -28.893 -14.627 1.00 24.11 ? 498 ILE B CB 1 ATOM 3327 C CG1 . ILE A 1 442 ? 35.976 -27.443 -14.229 1.00 24.01 ? 498 ILE B CG1 1 ATOM 3328 C CG2 . ILE A 1 442 ? 36.324 -29.835 -13.630 1.00 24.67 ? 498 ILE B CG2 1 ATOM 3329 C CD1 . ILE A 1 442 ? 35.152 -26.975 -13.051 1.00 27.44 ? 498 ILE B CD1 1 ATOM 3330 N N . SER A 1 443 ? 38.357 -30.346 -16.178 1.00 28.22 ? 499 SER B N 1 ATOM 3331 C CA . SER A 1 443 ? 39.810 -30.458 -16.252 1.00 23.72 ? 499 SER B CA 1 ATOM 3332 C C . SER A 1 443 ? 40.346 -29.717 -17.461 1.00 17.71 ? 499 SER B C 1 ATOM 3333 O O . SER A 1 443 ? 41.537 -29.404 -17.523 1.00 13.21 ? 499 SER B O 1 ATOM 3334 C CB . SER A 1 443 ? 40.232 -31.914 -16.360 1.00 20.09 ? 499 SER B CB 1 ATOM 3335 O OG . SER A 1 443 ? 40.617 -32.197 -17.689 1.00 13.14 ? 499 SER B OG 1 ATOM 3336 N N . GLY A 1 444 ? 39.463 -29.457 -18.421 1.00 17.33 ? 500 GLY B N 1 ATOM 3337 C CA . GLY A 1 444 ? 39.812 -28.711 -19.610 1.00 17.77 ? 500 GLY B CA 1 ATOM 3338 C C . GLY A 1 444 ? 39.697 -27.203 -19.481 1.00 28.33 ? 500 GLY B C 1 ATOM 3339 O O . GLY A 1 444 ? 39.751 -26.492 -20.487 1.00 29.57 ? 500 GLY B O 1 ATOM 3340 N N . CYS A 1 445 ? 39.547 -26.687 -18.263 1.00 35.31 ? 501 CYS B N 1 ATOM 3341 C CA . CYS A 1 445 ? 39.577 -25.240 -18.124 1.00 35.62 ? 501 CYS B CA 1 ATOM 3342 C C . CYS A 1 445 ? 41.020 -24.882 -17.833 1.00 48.20 ? 501 CYS B C 1 ATOM 3343 O O . CYS A 1 445 ? 41.486 -24.993 -16.700 1.00 54.64 ? 501 CYS B O 1 ATOM 3344 C CB . CYS A 1 445 ? 38.683 -24.781 -16.972 1.00 20.83 ? 501 CYS B CB 1 ATOM 3345 S SG . CYS A 1 445 ? 36.903 -25.025 -17.217 1.00 19.52 ? 501 CYS B SG 1 ATOM 3346 N N . GLU A 1 446 ? 41.701 -24.366 -18.849 1.00 46.12 ? 502 GLU B N 1 ATOM 3347 C CA . GLU A 1 446 ? 43.137 -24.160 -18.774 1.00 40.56 ? 502 GLU B CA 1 ATOM 3348 C C . GLU A 1 446 ? 43.453 -23.027 -17.814 1.00 23.34 ? 502 GLU B C 1 ATOM 3349 O O . GLU A 1 446 ? 44.509 -23.001 -17.201 1.00 17.83 ? 502 GLU B O 1 ATOM 3350 C CB . GLU A 1 446 ? 43.697 -23.822 -20.163 1.00 55.37 ? 502 GLU B CB 1 ATOM 3351 C CG . GLU A 1 446 ? 43.479 -24.891 -21.224 1.00 68.84 ? 502 GLU B CG 1 ATOM 3352 C CD . GLU A 1 446 ? 43.929 -24.439 -22.605 1.00 77.30 ? 502 GLU B CD 1 ATOM 3353 O OE1 . GLU A 1 446 ? 43.729 -25.197 -23.582 1.00 77.55 ? 502 GLU B OE1 1 ATOM 3354 O OE2 . GLU A 1 446 ? 44.481 -23.322 -22.711 1.00 80.92 ? 502 GLU B OE2 1 ATOM 3355 N N . SER A 1 447 ? 42.532 -22.073 -17.734 1.00 21.23 ? 503 SER B N 1 ATOM 3356 C CA . SER A 1 447 ? 42.739 -20.819 -17.027 1.00 9.84 ? 503 SER B CA 1 ATOM 3357 C C . SER A 1 447 ? 42.136 -20.726 -15.628 1.00 9.41 ? 503 SER B C 1 ATOM 3358 O O . SER A 1 447 ? 42.229 -19.676 -14.991 1.00 11.49 ? 503 SER B O 1 ATOM 3359 C CB . SER A 1 447 ? 42.231 -19.664 -17.886 1.00 9.49 ? 503 SER B CB 1 ATOM 3360 O OG . SER A 1 447 ? 43.273 -19.199 -18.713 1.00 22.93 ? 503 SER B OG 1 ATOM 3361 N N . LEU A 1 448 ? 41.521 -21.801 -15.149 1.00 22.27 ? 504 LEU B N 1 ATOM 3362 C CA . LEU A 1 448 ? 40.698 -21.699 -13.949 1.00 19.37 ? 504 LEU B CA 1 ATOM 3363 C C . LEU A 1 448 ? 41.559 -21.680 -12.686 1.00 20.67 ? 504 LEU B C 1 ATOM 3364 O O . LEU A 1 448 ? 42.225 -22.668 -12.355 1.00 15.27 ? 504 LEU B O 1 ATOM 3365 C CB . LEU A 1 448 ? 39.722 -22.882 -13.915 1.00 8.74 ? 504 LEU B CB 1 ATOM 3366 C CG . LEU A 1 448 ? 38.689 -22.977 -12.793 1.00 16.48 ? 504 LEU B CG 1 ATOM 3367 C CD1 . LEU A 1 448 ? 37.963 -21.660 -12.638 1.00 7.74 ? 504 LEU B CD1 1 ATOM 3368 C CD2 . LEU A 1 448 ? 37.704 -24.112 -13.066 1.00 8.19 ? 504 LEU B CD2 1 ATOM 3369 N N . GLU A 1 449 ? 41.564 -20.533 -12.003 1.00 25.24 ? 505 GLU B N 1 ATOM 3370 C CA . GLU A 1 449 ? 42.290 -20.393 -10.741 1.00 21.74 ? 505 GLU B CA 1 ATOM 3371 C C . GLU A 1 449 ? 41.485 -20.401 -9.435 1.00 17.76 ? 505 GLU B C 1 ATOM 3372 O O . GLU A 1 449 ? 42.051 -20.649 -8.378 1.00 22.21 ? 505 GLU B O 1 ATOM 3373 C CB . GLU A 1 449 ? 43.164 -19.142 -10.800 1.00 16.73 ? 505 GLU B CB 1 ATOM 3374 C CG . GLU A 1 449 ? 44.063 -19.110 -12.017 1.00 21.38 ? 505 GLU B CG 1 ATOM 3375 C CD . GLU A 1 449 ? 44.743 -17.772 -12.187 1.00 35.06 ? 505 GLU B CD 1 ATOM 3376 O OE1 . GLU A 1 449 ? 44.611 -16.927 -11.272 1.00 32.86 ? 505 GLU B OE1 1 ATOM 3377 O OE2 . GLU A 1 449 ? 45.397 -17.562 -13.239 1.00 43.22 ? 505 GLU B OE2 1 ATOM 3378 N N . PHE A 1 450 ? 40.176 -20.164 -9.519 1.00 10.34 ? 506 PHE B N 1 ATOM 3379 C CA . PHE A 1 450 ? 39.334 -19.970 -8.337 1.00 10.56 ? 506 PHE B CA 1 ATOM 3380 C C . PHE A 1 450 ? 38.041 -20.738 -8.536 1.00 13.25 ? 506 PHE B C 1 ATOM 3381 O O . PHE A 1 450 ? 37.277 -20.425 -9.447 1.00 17.04 ? 506 PHE B O 1 ATOM 3382 C CB . PHE A 1 450 ? 39.021 -18.480 -8.132 1.00 12.81 ? 506 PHE B CB 1 ATOM 3383 C CG . PHE A 1 450 ? 38.280 -18.160 -6.833 1.00 20.67 ? 506 PHE B CG 1 ATOM 3384 C CD1 . PHE A 1 450 ? 36.908 -18.368 -6.712 1.00 15.47 ? 506 PHE B CD1 1 ATOM 3385 C CD2 . PHE A 1 450 ? 38.961 -17.627 -5.738 1.00 29.16 ? 506 PHE B CD2 1 ATOM 3386 C CE1 . PHE A 1 450 ? 36.232 -18.056 -5.518 1.00 10.69 ? 506 PHE B CE1 1 ATOM 3387 C CE2 . PHE A 1 450 ? 38.288 -17.312 -4.536 1.00 20.56 ? 506 PHE B CE2 1 ATOM 3388 C CZ . PHE A 1 450 ? 36.923 -17.532 -4.432 1.00 10.95 ? 506 PHE B CZ 1 ATOM 3389 N N . LEU A 1 451 ? 37.788 -21.736 -7.691 1.00 9.05 ? 507 LEU B N 1 ATOM 3390 C CA . LEU A 1 451 ? 36.593 -22.549 -7.850 1.00 12.48 ? 507 LEU B CA 1 ATOM 3391 C C . LEU A 1 451 ? 35.893 -22.740 -6.517 1.00 17.84 ? 507 LEU B C 1 ATOM 3392 O O . LEU A 1 451 ? 36.395 -23.444 -5.645 1.00 25.65 ? 507 LEU B O 1 ATOM 3393 C CB . LEU A 1 451 ? 36.946 -23.908 -8.469 1.00 7.52 ? 507 LEU B CB 1 ATOM 3394 C CG . LEU A 1 451 ? 35.788 -24.868 -8.779 1.00 10.96 ? 507 LEU B CG 1 ATOM 3395 C CD1 . LEU A 1 451 ? 34.776 -24.250 -9.711 1.00 6.99 ? 507 LEU B CD1 1 ATOM 3396 C CD2 . LEU A 1 451 ? 36.268 -26.193 -9.338 1.00 7.82 ? 507 LEU B CD2 1 ATOM 3397 N N . ASP A 1 452 ? 34.710 -22.151 -6.374 1.00 15.32 ? 508 ASP B N 1 ATOM 3398 C CA . ASP A 1 452 ? 33.963 -22.291 -5.136 1.00 14.19 ? 508 ASP B CA 1 ATOM 3399 C C . ASP A 1 452 ? 32.595 -22.941 -5.369 1.00 17.91 ? 508 ASP B C 1 ATOM 3400 O O . ASP A 1 452 ? 31.683 -22.332 -5.927 1.00 31.18 ? 508 ASP B O 1 ATOM 3401 C CB . ASP A 1 452 ? 33.820 -20.926 -4.463 1.00 12.29 ? 508 ASP B CB 1 ATOM 3402 C CG . ASP A 1 452 ? 33.017 -20.987 -3.191 1.00 23.04 ? 508 ASP B CG 1 ATOM 3403 O OD1 . ASP A 1 452 ? 32.988 -22.059 -2.552 1.00 29.81 ? 508 ASP B OD1 1 ATOM 3404 O OD2 . ASP A 1 452 ? 32.411 -19.955 -2.834 1.00 26.88 ? 508 ASP B OD2 1 ATOM 3405 N N . LEU A 1 453 ? 32.492 -24.195 -4.947 1.00 9.82 ? 509 LEU B N 1 ATOM 3406 C CA . LEU A 1 453 ? 31.271 -24.982 -4.999 1.00 5.83 ? 509 LEU B CA 1 ATOM 3407 C C . LEU A 1 453 ? 30.533 -25.154 -3.669 1.00 5.61 ? 509 LEU B C 1 ATOM 3408 O O . LEU A 1 453 ? 29.635 -25.987 -3.564 1.00 11.48 ? 509 LEU B O 1 ATOM 3409 C CB . LEU A 1 453 ? 31.536 -26.328 -5.669 1.00 13.05 ? 509 LEU B CB 1 ATOM 3410 C CG . LEU A 1 453 ? 32.122 -26.208 -7.082 1.00 17.04 ? 509 LEU B CG 1 ATOM 3411 C CD1 . LEU A 1 453 ? 32.337 -27.578 -7.698 1.00 19.34 ? 509 LEU B CD1 1 ATOM 3412 C CD2 . LEU A 1 453 ? 31.228 -25.354 -7.973 1.00 22.95 ? 509 LEU B CD2 1 ATOM 3413 N N . HIS A 1 454 ? 30.951 -24.444 -2.629 1.00 5.55 ? 510 HIS B N 1 ATOM 3414 C CA . HIS A 1 454 ? 30.467 -24.756 -1.283 1.00 6.89 ? 510 HIS B CA 1 ATOM 3415 C C . HIS A 1 454 ? 28.957 -24.630 -1.070 1.00 8.14 ? 510 HIS B C 1 ATOM 3416 O O . HIS A 1 454 ? 28.274 -23.914 -1.795 1.00 14.37 ? 510 HIS B O 1 ATOM 3417 C CB . HIS A 1 454 ? 31.256 -24.002 -0.211 1.00 5.48 ? 510 HIS B CB 1 ATOM 3418 C CG . HIS A 1 454 ? 30.790 -22.599 0.038 1.00 5.12 ? 510 HIS B CG 1 ATOM 3419 N ND1 . HIS A 1 454 ? 29.574 -22.308 0.606 1.00 4.76 ? 510 HIS B ND1 1 ATOM 3420 C CD2 . HIS A 1 454 ? 31.417 -21.412 -0.144 1.00 5.11 ? 510 HIS B CD2 1 ATOM 3421 C CE1 . HIS A 1 454 ? 29.454 -20.995 0.738 1.00 4.54 ? 510 HIS B CE1 1 ATOM 3422 N NE2 . HIS A 1 454 ? 30.559 -20.433 0.295 1.00 4.74 ? 510 HIS B NE2 1 ATOM 3423 N N . THR A 1 455 ? 28.445 -25.368 -0.088 1.00 8.50 ? 511 THR B N 1 ATOM 3424 C CA . THR A 1 455 ? 27.016 -25.377 0.224 1.00 4.65 ? 511 THR B CA 1 ATOM 3425 C C . THR A 1 455 ? 26.206 -25.759 -1.007 1.00 4.57 ? 511 THR B C 1 ATOM 3426 O O . THR A 1 455 ? 25.534 -24.949 -1.619 1.00 4.31 ? 511 THR B O 1 ATOM 3427 C CB . THR A 1 455 ? 26.530 -24.052 0.921 1.00 15.05 ? 511 THR B CB 1 ATOM 3428 O OG1 . THR A 1 455 ? 27.225 -23.891 2.161 1.00 4.42 ? 511 THR B OG1 1 ATOM 3429 C CG2 . THR A 1 455 ? 25.048 -24.093 1.240 1.00 3.98 ? 511 THR B CG2 1 ATOM 3430 N N . ASN A 1 456 ? 26.318 -27.019 -1.383 1.00 18.90 ? 512 ASN B N 1 ATOM 3431 C CA . ASN A 1 456 ? 25.518 -27.566 -2.457 1.00 8.31 ? 512 ASN B CA 1 ATOM 3432 C C . ASN A 1 456 ? 25.197 -29.000 -2.095 1.00 15.45 ? 512 ASN B C 1 ATOM 3433 O O . ASN A 1 456 ? 25.612 -29.499 -1.048 1.00 26.51 ? 512 ASN B O 1 ATOM 3434 C CB . ASN A 1 456 ? 26.289 -27.511 -3.785 1.00 10.81 ? 512 ASN B CB 1 ATOM 3435 C CG . ASN A 1 456 ? 25.971 -26.272 -4.602 1.00 12.86 ? 512 ASN B CG 1 ATOM 3436 O OD1 . ASN A 1 456 ? 24.813 -25.979 -4.858 1.00 20.31 ? 512 ASN B OD1 1 ATOM 3437 N ND2 . ASN A 1 456 ? 26.997 -25.545 -5.018 1.00 4.90 ? 512 ASN B ND2 1 ATOM 3438 N N . SER A 1 457 ? 24.461 -29.663 -2.967 1.00 14.88 ? 513 SER B N 1 ATOM 3439 C CA . SER A 1 457 ? 24.126 -31.069 -2.790 1.00 14.79 ? 513 SER B CA 1 ATOM 3440 C C . SER A 1 457 ? 25.078 -32.040 -3.499 1.00 14.52 ? 513 SER B C 1 ATOM 3441 O O . SER A 1 457 ? 24.772 -33.220 -3.608 1.00 20.15 ? 513 SER B O 1 ATOM 3442 C CB . SER A 1 457 ? 22.664 -31.328 -3.133 1.00 24.18 ? 513 SER B CB 1 ATOM 3443 O OG . SER A 1 457 ? 21.841 -30.490 -2.332 1.00 29.32 ? 513 SER B OG 1 ATOM 3444 N N . LEU A 1 458 ? 26.208 -31.540 -3.996 1.00 5.86 ? 514 LEU B N 1 ATOM 3445 C CA . LEU A 1 458 ? 27.166 -32.368 -4.747 1.00 17.68 ? 514 LEU B CA 1 ATOM 3446 C C . LEU A 1 458 ? 27.545 -33.674 -4.046 1.00 25.85 ? 514 LEU B C 1 ATOM 3447 O O . LEU A 1 458 ? 27.682 -33.716 -2.831 1.00 33.34 ? 514 LEU B O 1 ATOM 3448 C CB . LEU A 1 458 ? 28.460 -31.591 -5.002 1.00 12.37 ? 514 LEU B CB 1 ATOM 3449 C CG . LEU A 1 458 ? 28.437 -30.409 -5.962 1.00 10.28 ? 514 LEU B CG 1 ATOM 3450 C CD1 . LEU A 1 458 ? 29.804 -29.753 -6.006 1.00 12.12 ? 514 LEU B CD1 1 ATOM 3451 C CD2 . LEU A 1 458 ? 28.041 -30.908 -7.321 1.00 10.82 ? 514 LEU B CD2 1 ATOM 3452 N N . SER A 1 459 ? 27.715 -34.739 -4.825 1.00 24.89 ? 515 SER B N 1 ATOM 3453 C CA . SER A 1 459 ? 28.093 -36.038 -4.273 1.00 18.64 ? 515 SER B CA 1 ATOM 3454 C C . SER A 1 459 ? 29.115 -36.751 -5.140 1.00 20.84 ? 515 SER B C 1 ATOM 3455 O O . SER A 1 459 ? 29.715 -36.158 -6.037 1.00 22.06 ? 515 SER B O 1 ATOM 3456 C CB . SER A 1 459 ? 26.874 -36.937 -4.067 1.00 13.98 ? 515 SER B CB 1 ATOM 3457 O OG . SER A 1 459 ? 26.262 -37.284 -5.295 1.00 7.34 ? 515 SER B OG 1 ATOM 3458 N N . GLY A 1 460 ? 29.339 -38.022 -4.834 1.00 24.81 ? 516 GLY B N 1 ATOM 3459 C CA . GLY A 1 460 ? 30.259 -38.834 -5.603 1.00 31.37 ? 516 GLY B CA 1 ATOM 3460 C C . GLY A 1 460 ? 31.670 -38.729 -5.070 1.00 35.65 ? 516 GLY B C 1 ATOM 3461 O O . GLY A 1 460 ? 31.890 -38.254 -3.950 1.00 36.91 ? 516 GLY B O 1 ATOM 3462 N N . SER A 1 461 ? 32.626 -39.168 -5.884 1.00 31.31 ? 517 SER B N 1 ATOM 3463 C CA . SER A 1 461 ? 34.023 -39.229 -5.480 1.00 19.31 ? 517 SER B CA 1 ATOM 3464 C C . SER A 1 461 ? 34.873 -38.162 -6.186 1.00 15.81 ? 517 SER B C 1 ATOM 3465 O O . SER A 1 461 ? 34.818 -38.003 -7.398 1.00 24.15 ? 517 SER B O 1 ATOM 3466 C CB . SER A 1 461 ? 34.573 -40.629 -5.769 1.00 17.85 ? 517 SER B CB 1 ATOM 3467 O OG . SER A 1 461 ? 35.707 -40.922 -4.971 1.00 27.08 ? 517 SER B OG 1 ATOM 3468 N N . LEU A 1 462 ? 35.669 -37.435 -5.417 1.00 15.92 ? 518 LEU B N 1 ATOM 3469 C CA . LEU A 1 462 ? 36.586 -36.456 -5.983 1.00 25.44 ? 518 LEU B CA 1 ATOM 3470 C C . LEU A 1 462 ? 37.667 -37.190 -6.798 1.00 26.41 ? 518 LEU B C 1 ATOM 3471 O O . LEU A 1 462 ? 37.801 -38.405 -6.691 1.00 28.40 ? 518 LEU B O 1 ATOM 3472 C CB . LEU A 1 462 ? 37.211 -35.618 -4.861 1.00 33.33 ? 518 LEU B CB 1 ATOM 3473 C CG . LEU A 1 462 ? 37.417 -34.120 -5.097 1.00 34.85 ? 518 LEU B CG 1 ATOM 3474 C CD1 . LEU A 1 462 ? 36.073 -33.416 -5.199 1.00 39.38 ? 518 LEU B CD1 1 ATOM 3475 C CD2 . LEU A 1 462 ? 38.263 -33.516 -3.992 1.00 32.30 ? 518 LEU B CD2 1 ATOM 3476 N N . LEU A 1 463 ? 38.383 -36.474 -7.659 1.00 27.75 ? 519 LEU B N 1 ATOM 3477 C CA . LEU A 1 463 ? 39.510 -37.059 -8.390 1.00 43.32 ? 519 LEU B CA 1 ATOM 3478 C C . LEU A 1 463 ? 40.563 -35.992 -8.692 1.00 55.35 ? 519 LEU B C 1 ATOM 3479 O O . LEU A 1 463 ? 40.234 -34.840 -8.987 1.00 59.55 ? 519 LEU B O 1 ATOM 3480 C CB . LEU A 1 463 ? 39.064 -37.723 -9.712 1.00 37.93 ? 519 LEU B CB 1 ATOM 3481 C CG . LEU A 1 463 ? 38.673 -39.203 -9.864 1.00 24.44 ? 519 LEU B CG 1 ATOM 3482 C CD1 . LEU A 1 463 ? 39.270 -40.094 -8.770 1.00 23.10 ? 519 LEU B CD1 1 ATOM 3483 C CD2 . LEU A 1 463 ? 37.158 -39.371 -9.943 1.00 16.82 ? 519 LEU B CD2 1 ATOM 3484 N N . GLY A 1 464 ? 41.829 -36.382 -8.641 1.00 56.87 ? 520 GLY B N 1 ATOM 3485 C CA . GLY A 1 464 ? 42.903 -35.466 -8.966 1.00 58.88 ? 520 GLY B CA 1 ATOM 3486 C C . GLY A 1 464 ? 42.994 -35.185 -10.454 1.00 56.31 ? 520 GLY B C 1 ATOM 3487 O O . GLY A 1 464 ? 43.581 -34.181 -10.857 1.00 52.91 ? 520 GLY B O 1 ATOM 3488 N N . THR A 1 465 ? 42.421 -36.073 -11.268 1.00 59.50 ? 521 THR B N 1 ATOM 3489 C CA . THR A 1 465 ? 42.463 -35.933 -12.733 1.00 58.31 ? 521 THR B CA 1 ATOM 3490 C C . THR A 1 465 ? 41.312 -35.066 -13.238 1.00 42.55 ? 521 THR B C 1 ATOM 3491 O O . THR A 1 465 ? 41.222 -34.757 -14.420 1.00 30.59 ? 521 THR B O 1 ATOM 3492 C CB . THR A 1 465 ? 42.405 -37.305 -13.465 1.00 62.30 ? 521 THR B CB 1 ATOM 3493 O OG1 . THR A 1 465 ? 41.077 -37.544 -13.953 1.00 62.34 ? 521 THR B OG1 1 ATOM 3494 C CG2 . THR A 1 465 ? 42.843 -38.448 -12.539 1.00 60.56 ? 521 THR B CG2 1 ATOM 3495 N N . THR A 1 466 ? 40.436 -34.687 -12.317 1.00 37.49 ? 522 THR B N 1 ATOM 3496 C CA . THR A 1 466 ? 39.252 -33.910 -12.630 1.00 23.34 ? 522 THR B CA 1 ATOM 3497 C C . THR A 1 466 ? 39.548 -32.412 -12.502 1.00 28.52 ? 522 THR B C 1 ATOM 3498 O O . THR A 1 466 ? 38.748 -31.572 -12.899 1.00 36.46 ? 522 THR B O 1 ATOM 3499 C CB . THR A 1 466 ? 38.113 -34.331 -11.676 1.00 18.02 ? 522 THR B CB 1 ATOM 3500 O OG1 . THR A 1 466 ? 37.900 -35.742 -11.790 1.00 15.36 ? 522 THR B OG1 1 ATOM 3501 C CG2 . THR A 1 466 ? 36.819 -33.623 -11.985 1.00 25.79 ? 522 THR B CG2 1 ATOM 3502 N N . LEU A 1 467 ? 40.708 -32.071 -11.953 1.00 22.29 ? 523 LEU B N 1 ATOM 3503 C CA . LEU A 1 467 ? 40.997 -30.675 -11.660 1.00 23.57 ? 523 LEU B CA 1 ATOM 3504 C C . LEU A 1 467 ? 42.096 -30.046 -12.520 1.00 31.00 ? 523 LEU B C 1 ATOM 3505 O O . LEU A 1 467 ? 43.205 -30.578 -12.603 1.00 36.47 ? 523 LEU B O 1 ATOM 3506 C CB . LEU A 1 467 ? 41.292 -30.496 -10.168 1.00 31.17 ? 523 LEU B CB 1 ATOM 3507 C CG . LEU A 1 467 ? 40.188 -30.960 -9.203 1.00 33.90 ? 523 LEU B CG 1 ATOM 3508 C CD1 . LEU A 1 467 ? 40.676 -30.917 -7.755 1.00 31.30 ? 523 LEU B CD1 1 ATOM 3509 C CD2 . LEU A 1 467 ? 38.898 -30.142 -9.373 1.00 29.65 ? 523 LEU B CD2 1 ATOM 3510 N N . PRO A 1 468 ? 41.787 -28.915 -13.177 1.00 26.81 ? 524 PRO B N 1 ATOM 3511 C CA . PRO A 1 468 ? 42.840 -28.138 -13.832 1.00 18.15 ? 524 PRO B CA 1 ATOM 3512 C C . PRO A 1 468 ? 43.966 -27.793 -12.874 1.00 16.75 ? 524 PRO B C 1 ATOM 3513 O O . PRO A 1 468 ? 43.731 -27.330 -11.760 1.00 24.36 ? 524 PRO B O 1 ATOM 3514 C CB . PRO A 1 468 ? 42.122 -26.862 -14.277 1.00 10.60 ? 524 PRO B CB 1 ATOM 3515 C CG . PRO A 1 468 ? 40.782 -26.901 -13.640 1.00 30.09 ? 524 PRO B CG 1 ATOM 3516 C CD . PRO A 1 468 ? 40.459 -28.334 -13.417 1.00 26.57 ? 524 PRO B CD 1 ATOM 3517 N N . LYS A 1 469 ? 45.186 -27.989 -13.349 1.00 19.13 ? 525 LYS B N 1 ATOM 3518 C CA . LYS A 1 469 ? 46.398 -27.889 -12.545 1.00 24.51 ? 525 LYS B CA 1 ATOM 3519 C C . LYS A 1 469 ? 46.752 -26.455 -12.114 1.00 22.96 ? 525 LYS B C 1 ATOM 3520 O O . LYS A 1 469 ? 47.667 -26.240 -11.315 1.00 19.89 ? 525 LYS B O 1 ATOM 3521 C CB . LYS A 1 469 ? 47.563 -28.522 -13.322 1.00 21.19 ? 525 LYS B CB 1 ATOM 3522 C CG . LYS A 1 469 ? 47.718 -30.035 -13.125 1.00 23.55 ? 525 LYS B CG 1 ATOM 3523 C CD . LYS A 1 469 ? 46.393 -30.796 -13.189 1.00 24.71 ? 525 LYS B CD 1 ATOM 3524 C CE . LYS A 1 469 ? 46.496 -32.128 -12.472 1.00 33.94 ? 525 LYS B CE 1 ATOM 3525 N NZ . LYS A 1 469 ? 45.395 -33.047 -12.848 1.00 42.36 ? 525 LYS B NZ 1 ATOM 3526 N N . SER A 1 470 ? 46.019 -25.484 -12.648 1.00 19.50 ? 526 SER B N 1 ATOM 3527 C CA . SER A 1 470 ? 46.307 -24.068 -12.429 1.00 17.44 ? 526 SER B CA 1 ATOM 3528 C C . SER A 1 470 ? 45.501 -23.458 -11.288 1.00 17.95 ? 526 SER B C 1 ATOM 3529 O O . SER A 1 470 ? 45.548 -22.241 -11.072 1.00 10.86 ? 526 SER B O 1 ATOM 3530 C CB . SER A 1 470 ? 46.072 -23.271 -13.723 1.00 15.40 ? 526 SER B CB 1 ATOM 3531 O OG . SER A 1 470 ? 44.742 -23.425 -14.189 1.00 14.09 ? 526 SER B OG 1 ATOM 3532 N N . LEU A 1 471 ? 44.747 -24.302 -10.583 1.00 14.18 ? 527 LEU B N 1 ATOM 3533 C CA . LEU A 1 471 ? 43.859 -23.840 -9.519 1.00 15.32 ? 527 LEU B CA 1 ATOM 3534 C C . LEU A 1 471 ? 44.620 -23.296 -8.311 1.00 16.31 ? 527 LEU B C 1 ATOM 3535 O O . LEU A 1 471 ? 45.485 -23.963 -7.751 1.00 11.14 ? 527 LEU B O 1 ATOM 3536 C CB . LEU A 1 471 ? 42.903 -24.959 -9.102 1.00 9.97 ? 527 LEU B CB 1 ATOM 3537 C CG . LEU A 1 471 ? 41.610 -24.963 -9.924 1.00 30.55 ? 527 LEU B CG 1 ATOM 3538 C CD1 . LEU A 1 471 ? 40.831 -26.268 -9.815 1.00 9.50 ? 527 LEU B CD1 1 ATOM 3539 C CD2 . LEU A 1 471 ? 40.745 -23.777 -9.501 1.00 26.91 ? 527 LEU B CD2 1 ATOM 3540 N N . LYS A 1 472 ? 44.342 -22.040 -7.978 1.00 17.49 ? 528 LYS B N 1 ATOM 3541 C CA . LYS A 1 472 ? 44.838 -21.428 -6.757 1.00 23.23 ? 528 LYS B CA 1 ATOM 3542 C C . LYS A 1 472 ? 43.943 -21.689 -5.540 1.00 31.54 ? 528 LYS B C 1 ATOM 3543 O O . LYS A 1 472 ? 44.428 -21.787 -4.412 1.00 32.99 ? 528 LYS B O 1 ATOM 3544 C CB . LYS A 1 472 ? 45.048 -19.924 -6.960 1.00 21.74 ? 528 LYS B CB 1 ATOM 3545 C CG . LYS A 1 472 ? 46.103 -19.566 -8.003 1.00 17.57 ? 528 LYS B CG 1 ATOM 3546 C CD . LYS A 1 472 ? 46.467 -18.087 -7.930 1.00 13.88 ? 528 LYS B CD 1 ATOM 3547 C CE . LYS A 1 472 ? 47.338 -17.651 -9.107 1.00 15.38 ? 528 LYS B CE 1 ATOM 3548 N NZ . LYS A 1 472 ? 48.610 -18.434 -9.226 1.00 12.10 ? 528 LYS B NZ 1 ATOM 3549 N N . PHE A 1 473 ? 42.634 -21.769 -5.783 1.00 35.67 ? 529 PHE B N 1 ATOM 3550 C CA . PHE A 1 473 ? 41.632 -21.730 -4.715 1.00 8.55 ? 529 PHE B CA 1 ATOM 3551 C C . PHE A 1 473 ? 40.463 -22.698 -4.943 1.00 8.30 ? 529 PHE B C 1 ATOM 3552 O O . PHE A 1 473 ? 39.756 -22.594 -5.934 1.00 8.07 ? 529 PHE B O 1 ATOM 3553 C CB . PHE A 1 473 ? 41.127 -20.292 -4.591 1.00 16.71 ? 529 PHE B CB 1 ATOM 3554 C CG . PHE A 1 473 ? 40.122 -20.082 -3.504 1.00 28.41 ? 529 PHE B CG 1 ATOM 3555 C CD1 . PHE A 1 473 ? 38.786 -20.419 -3.690 1.00 31.84 ? 529 PHE B CD1 1 ATOM 3556 C CD2 . PHE A 1 473 ? 40.496 -19.518 -2.304 1.00 33.80 ? 529 PHE B CD2 1 ATOM 3557 C CE1 . PHE A 1 473 ? 37.853 -20.222 -2.691 1.00 24.03 ? 529 PHE B CE1 1 ATOM 3558 C CE2 . PHE A 1 473 ? 39.561 -19.319 -1.298 1.00 24.70 ? 529 PHE B CE2 1 ATOM 3559 C CZ . PHE A 1 473 ? 38.241 -19.672 -1.496 1.00 12.53 ? 529 PHE B CZ 1 ATOM 3560 N N . ILE A 1 474 ? 40.240 -23.606 -3.995 1.00 25.56 ? 530 ILE B N 1 ATOM 3561 C CA . ILE A 1 474 ? 39.185 -24.615 -4.102 1.00 8.15 ? 530 ILE B CA 1 ATOM 3562 C C . ILE A 1 474 ? 38.369 -24.729 -2.822 1.00 25.37 ? 530 ILE B C 1 ATOM 3563 O O . ILE A 1 474 ? 38.926 -25.047 -1.775 1.00 31.30 ? 530 ILE B O 1 ATOM 3564 C CB . ILE A 1 474 ? 39.789 -26.003 -4.323 1.00 22.82 ? 530 ILE B CB 1 ATOM 3565 C CG1 . ILE A 1 474 ? 40.509 -26.088 -5.667 1.00 15.95 ? 530 ILE B CG1 1 ATOM 3566 C CG2 . ILE A 1 474 ? 38.718 -27.091 -4.208 1.00 23.09 ? 530 ILE B CG2 1 ATOM 3567 C CD1 . ILE A 1 474 ? 41.230 -27.404 -5.857 1.00 16.04 ? 530 ILE B CD1 1 ATOM 3568 N N . ASP A 1 475 ? 37.070 -24.432 -2.886 1.00 20.99 ? 531 ASP B N 1 ATOM 3569 C CA . ASP A 1 475 ? 36.177 -24.701 -1.758 1.00 14.64 ? 531 ASP B CA 1 ATOM 3570 C C . ASP A 1 475 ? 35.039 -25.625 -2.164 1.00 11.65 ? 531 ASP B C 1 ATOM 3571 O O . ASP A 1 475 ? 34.114 -25.197 -2.837 1.00 9.32 ? 531 ASP B O 1 ATOM 3572 C CB . ASP A 1 475 ? 35.595 -23.377 -1.271 1.00 15.37 ? 531 ASP B CB 1 ATOM 3573 C CG . ASP A 1 475 ? 34.842 -23.502 0.051 1.00 14.23 ? 531 ASP B CG 1 ATOM 3574 O OD1 . ASP A 1 475 ? 34.571 -24.631 0.504 1.00 10.49 ? 531 ASP B OD1 1 ATOM 3575 O OD2 . ASP A 1 475 ? 34.505 -22.448 0.634 1.00 14.02 ? 531 ASP B OD2 1 ATOM 3576 N N . PHE A 1 476 ? 35.110 -26.883 -1.738 1.00 7.14 ? 532 PHE B N 1 ATOM 3577 C CA . PHE A 1 476 ? 34.016 -27.853 -1.914 1.00 16.52 ? 532 PHE B CA 1 ATOM 3578 C C . PHE A 1 476 ? 33.184 -28.099 -0.647 1.00 12.61 ? 532 PHE B C 1 ATOM 3579 O O . PHE A 1 476 ? 32.428 -29.064 -0.559 1.00 6.71 ? 532 PHE B O 1 ATOM 3580 C CB . PHE A 1 476 ? 34.496 -29.161 -2.544 1.00 7.43 ? 532 PHE B CB 1 ATOM 3581 C CG . PHE A 1 476 ? 35.151 -28.983 -3.878 1.00 15.73 ? 532 PHE B CG 1 ATOM 3582 C CD1 . PHE A 1 476 ? 34.981 -27.812 -4.602 1.00 10.58 ? 532 PHE B CD1 1 ATOM 3583 C CD2 . PHE A 1 476 ? 35.940 -29.984 -4.411 1.00 8.17 ? 532 PHE B CD2 1 ATOM 3584 C CE1 . PHE A 1 476 ? 35.585 -27.647 -5.827 1.00 9.70 ? 532 PHE B CE1 1 ATOM 3585 C CE2 . PHE A 1 476 ? 36.547 -29.820 -5.627 1.00 9.44 ? 532 PHE B CE2 1 ATOM 3586 C CZ . PHE A 1 476 ? 36.366 -28.652 -6.339 1.00 8.15 ? 532 PHE B CZ 1 ATOM 3587 N N . SER A 1 477 ? 33.402 -27.281 0.369 1.00 15.96 ? 533 SER B N 1 ATOM 3588 C CA . SER A 1 477 ? 32.790 -27.529 1.668 1.00 18.80 ? 533 SER B CA 1 ATOM 3589 C C . SER A 1 477 ? 31.277 -27.579 1.630 1.00 11.93 ? 533 SER B C 1 ATOM 3590 O O . SER A 1 477 ? 30.633 -26.999 0.761 1.00 8.02 ? 533 SER B O 1 ATOM 3591 C CB . SER A 1 477 ? 33.200 -26.480 2.682 1.00 6.38 ? 533 SER B CB 1 ATOM 3592 O OG . SER A 1 477 ? 32.578 -25.258 2.354 1.00 12.85 ? 533 SER B OG 1 ATOM 3593 N N . ASP A 1 478 ? 30.727 -28.311 2.584 1.00 9.31 ? 534 ASP B N 1 ATOM 3594 C CA . ASP A 1 478 ? 29.288 -28.406 2.758 1.00 12.46 ? 534 ASP B CA 1 ATOM 3595 C C . ASP A 1 478 ? 28.627 -29.005 1.524 1.00 10.80 ? 534 ASP B C 1 ATOM 3596 O O . ASP A 1 478 ? 27.862 -28.348 0.821 1.00 7.55 ? 534 ASP B O 1 ATOM 3597 C CB . ASP A 1 478 ? 28.716 -27.030 3.106 1.00 17.22 ? 534 ASP B CB 1 ATOM 3598 C CG . ASP A 1 478 ? 27.299 -27.099 3.593 1.00 15.89 ? 534 ASP B CG 1 ATOM 3599 O OD1 . ASP A 1 478 ? 26.869 -28.203 4.015 1.00 10.43 ? 534 ASP B OD1 1 ATOM 3600 O OD2 . ASP A 1 478 ? 26.623 -26.043 3.538 1.00 4.60 ? 534 ASP B OD2 1 ATOM 3601 N N . ASN A 1 479 ? 28.952 -30.273 1.285 1.00 11.34 ? 535 ASN B N 1 ATOM 3602 C CA . ASN A 1 479 ? 28.394 -31.081 0.205 1.00 11.42 ? 535 ASN B CA 1 ATOM 3603 C C . ASN A 1 479 ? 28.233 -32.503 0.722 1.00 14.44 ? 535 ASN B C 1 ATOM 3604 O O . ASN A 1 479 ? 28.345 -32.742 1.932 1.00 20.96 ? 535 ASN B O 1 ATOM 3605 C CB . ASN A 1 479 ? 29.288 -31.056 -1.044 1.00 6.29 ? 535 ASN B CB 1 ATOM 3606 C CG . ASN A 1 479 ? 29.115 -29.791 -1.863 1.00 11.60 ? 535 ASN B CG 1 ATOM 3607 O OD1 . ASN A 1 479 ? 28.101 -29.603 -2.518 1.00 5.79 ? 535 ASN B OD1 1 ATOM 3608 N ND2 . ASN A 1 479 ? 30.105 -28.920 -1.829 1.00 6.12 ? 535 ASN B ND2 1 ATOM 3609 N N . ALA A 1 480 ? 27.898 -33.423 -0.178 1.00 10.88 ? 536 ALA B N 1 ATOM 3610 C CA . ALA A 1 480 ? 27.790 -34.850 0.130 1.00 9.83 ? 536 ALA B CA 1 ATOM 3611 C C . ALA A 1 480 ? 29.003 -35.693 -0.291 1.00 17.25 ? 536 ALA B C 1 ATOM 3612 O O . ALA A 1 480 ? 28.939 -36.926 -0.250 1.00 15.48 ? 536 ALA B O 1 ATOM 3613 C CB . ALA A 1 480 ? 26.518 -35.422 -0.441 1.00 19.02 ? 536 ALA B CB 1 ATOM 3614 N N . LEU A 1 481 ? 30.072 -35.039 -0.749 1.00 7.34 ? 537 LEU B N 1 ATOM 3615 C CA . LEU A 1 481 ? 31.231 -35.738 -1.314 1.00 7.85 ? 537 LEU B CA 1 ATOM 3616 C C . LEU A 1 481 ? 31.764 -36.865 -0.428 1.00 29.86 ? 537 LEU B C 1 ATOM 3617 O O . LEU A 1 481 ? 31.876 -36.724 0.786 1.00 25.26 ? 537 LEU B O 1 ATOM 3618 C CB . LEU A 1 481 ? 32.369 -34.755 -1.631 1.00 7.96 ? 537 LEU B CB 1 ATOM 3619 C CG . LEU A 1 481 ? 32.216 -33.747 -2.773 1.00 10.96 ? 537 LEU B CG 1 ATOM 3620 C CD1 . LEU A 1 481 ? 33.416 -32.828 -2.835 1.00 10.33 ? 537 LEU B CD1 1 ATOM 3621 C CD2 . LEU A 1 481 ? 32.046 -34.461 -4.092 1.00 8.85 ? 537 LEU B CD2 1 ATOM 3622 N N . SER A 1 482 ? 32.102 -37.986 -1.053 1.00 33.93 ? 538 SER B N 1 ATOM 3623 C CA . SER A 1 482 ? 32.502 -39.182 -0.319 1.00 30.69 ? 538 SER B CA 1 ATOM 3624 C C . SER A 1 482 ? 33.759 -39.829 -0.886 1.00 33.42 ? 538 SER B C 1 ATOM 3625 O O . SER A 1 482 ? 34.433 -39.277 -1.762 1.00 35.95 ? 538 SER B O 1 ATOM 3626 C CB . SER A 1 482 ? 31.368 -40.205 -0.295 1.00 29.01 ? 538 SER B CB 1 ATOM 3627 O OG . SER A 1 482 ? 31.024 -40.606 -1.613 1.00 32.20 ? 538 SER B OG 1 ATOM 3628 N N . SER A 1 483 ? 34.031 -41.023 -0.373 1.00 30.62 ? 539 SER B N 1 ATOM 3629 C CA . SER A 1 483 ? 35.271 -41.764 -0.571 1.00 29.39 ? 539 SER B CA 1 ATOM 3630 C C . SER A 1 483 ? 36.507 -40.997 -0.114 1.00 31.25 ? 539 SER B C 1 ATOM 3631 O O . SER A 1 483 ? 36.459 -40.257 0.865 1.00 36.07 ? 539 SER B O 1 ATOM 3632 C CB . SER A 1 483 ? 35.416 -42.199 -2.027 1.00 32.29 ? 539 SER B CB 1 ATOM 3633 O OG . SER A 1 483 ? 36.382 -43.229 -2.154 1.00 40.50 ? 539 SER B OG 1 ATOM 3634 N N . THR A 1 484 ? 37.604 -41.131 -0.839 1.00 13.43 ? 540 THR B N 1 ATOM 3635 C CA . THR A 1 484 ? 38.860 -40.635 -0.309 1.00 20.14 ? 540 THR B CA 1 ATOM 3636 C C . THR A 1 484 ? 39.378 -39.460 -1.078 1.00 17.40 ? 540 THR B C 1 ATOM 3637 O O . THR A 1 484 ? 39.068 -39.282 -2.250 1.00 29.66 ? 540 THR B O 1 ATOM 3638 C CB . THR A 1 484 ? 39.970 -41.684 -0.331 1.00 25.20 ? 540 THR B CB 1 ATOM 3639 O OG1 . THR A 1 484 ? 40.635 -41.629 -1.598 1.00 32.70 ? 540 THR B OG1 1 ATOM 3640 C CG2 . THR A 1 484 ? 39.406 -43.075 -0.080 1.00 23.63 ? 540 THR B CG2 1 ATOM 3641 N N . LEU A 1 485 ? 40.149 -38.640 -0.383 1.00 21.01 ? 541 LEU B N 1 ATOM 3642 C CA . LEU A 1 485 ? 40.881 -37.568 -1.017 1.00 25.05 ? 541 LEU B CA 1 ATOM 3643 C C . LEU A 1 485 ? 41.881 -38.256 -1.944 1.00 25.86 ? 541 LEU B C 1 ATOM 3644 O O . LEU A 1 485 ? 42.526 -39.228 -1.562 1.00 22.07 ? 541 LEU B O 1 ATOM 3645 C CB . LEU A 1 485 ? 41.547 -36.685 0.046 1.00 21.97 ? 541 LEU B CB 1 ATOM 3646 C CG . LEU A 1 485 ? 42.294 -35.414 -0.370 1.00 21.16 ? 541 LEU B CG 1 ATOM 3647 C CD1 . LEU A 1 485 ? 41.425 -34.458 -1.165 1.00 20.73 ? 541 LEU B CD1 1 ATOM 3648 C CD2 . LEU A 1 485 ? 42.857 -34.716 0.858 1.00 19.69 ? 541 LEU B CD2 1 ATOM 3649 N N . PRO A 1 486 ? 41.949 -37.809 -3.202 1.00 37.78 ? 542 PRO B N 1 ATOM 3650 C CA . PRO A 1 486 ? 42.828 -38.522 -4.133 1.00 40.04 ? 542 PRO B CA 1 ATOM 3651 C C . PRO A 1 486 ? 44.293 -38.142 -3.942 1.00 42.88 ? 542 PRO B C 1 ATOM 3652 O O . PRO A 1 486 ? 44.589 -37.054 -3.439 1.00 44.42 ? 542 PRO B O 1 ATOM 3653 C CB . PRO A 1 486 ? 42.324 -38.062 -5.499 1.00 41.65 ? 542 PRO B CB 1 ATOM 3654 C CG . PRO A 1 486 ? 41.720 -36.713 -5.247 1.00 42.33 ? 542 PRO B CG 1 ATOM 3655 C CD . PRO A 1 486 ? 41.144 -36.766 -3.864 1.00 38.40 ? 542 PRO B CD 1 ATOM 3656 N N . PRO A 1 487 ? 45.211 -39.047 -4.310 1.00 42.71 ? 543 PRO B N 1 ATOM 3657 C CA . PRO A 1 487 ? 46.628 -38.678 -4.354 1.00 41.08 ? 543 PRO B CA 1 ATOM 3658 C C . PRO A 1 487 ? 46.895 -37.628 -5.421 1.00 39.13 ? 543 PRO B C 1 ATOM 3659 O O . PRO A 1 487 ? 47.886 -36.901 -5.332 1.00 40.36 ? 543 PRO B O 1 ATOM 3660 C CB . PRO A 1 487 ? 47.330 -39.994 -4.705 1.00 18.98 ? 543 PRO B CB 1 ATOM 3661 C CG . PRO A 1 487 ? 46.253 -40.942 -5.094 1.00 42.54 ? 543 PRO B CG 1 ATOM 3662 C CD . PRO A 1 487 ? 45.019 -40.501 -4.406 1.00 44.10 ? 543 PRO B CD 1 ATOM 3663 N N . GLY A 1 488 ? 45.997 -37.541 -6.402 1.00 37.14 ? 544 GLY B N 1 ATOM 3664 C CA . GLY A 1 488 ? 46.106 -36.577 -7.481 1.00 32.98 ? 544 GLY B CA 1 ATOM 3665 C C . GLY A 1 488 ? 46.170 -35.153 -6.975 1.00 30.09 ? 544 GLY B C 1 ATOM 3666 O O . GLY A 1 488 ? 46.616 -34.246 -7.675 1.00 28.41 ? 544 GLY B O 1 ATOM 3667 N N . ILE A 1 489 ? 45.726 -34.963 -5.740 1.00 36.32 ? 545 ILE B N 1 ATOM 3668 C CA . ILE A 1 489 ? 45.767 -33.664 -5.089 1.00 41.56 ? 545 ILE B CA 1 ATOM 3669 C C . ILE A 1 489 ? 47.191 -33.114 -5.117 1.00 44.51 ? 545 ILE B C 1 ATOM 3670 O O . ILE A 1 489 ? 47.398 -31.900 -5.166 1.00 45.19 ? 545 ILE B O 1 ATOM 3671 C CB . ILE A 1 489 ? 45.227 -33.754 -3.633 1.00 39.25 ? 545 ILE B CB 1 ATOM 3672 C CG1 . ILE A 1 489 ? 44.139 -32.700 -3.384 1.00 34.14 ? 545 ILE B CG1 1 ATOM 3673 C CG2 . ILE A 1 489 ? 46.359 -33.676 -2.602 1.00 43.34 ? 545 ILE B CG2 1 ATOM 3674 C CD1 . ILE A 1 489 ? 44.569 -31.278 -3.696 1.00 35.81 ? 545 ILE B CD1 1 ATOM 3675 N N . GLY A 1 490 ? 48.167 -34.020 -5.130 1.00 41.92 ? 546 GLY B N 1 ATOM 3676 C CA . GLY A 1 490 ? 49.564 -33.638 -5.142 1.00 37.75 ? 546 GLY B CA 1 ATOM 3677 C C . GLY A 1 490 ? 49.963 -32.955 -6.432 1.00 35.79 ? 546 GLY B C 1 ATOM 3678 O O . GLY A 1 490 ? 51.072 -32.447 -6.547 1.00 42.44 ? 546 GLY B O 1 ATOM 3679 N N . LEU A 1 491 ? 49.064 -32.944 -7.409 1.00 26.26 ? 547 LEU B N 1 ATOM 3680 C CA . LEU A 1 491 ? 49.361 -32.326 -8.691 1.00 30.99 ? 547 LEU B CA 1 ATOM 3681 C C . LEU A 1 491 ? 48.931 -30.865 -8.812 1.00 41.44 ? 547 LEU B C 1 ATOM 3682 O O . LEU A 1 491 ? 49.272 -30.210 -9.796 1.00 45.71 ? 547 LEU B O 1 ATOM 3683 C CB . LEU A 1 491 ? 48.777 -33.155 -9.833 1.00 33.19 ? 547 LEU B CB 1 ATOM 3684 C CG . LEU A 1 491 ? 49.405 -34.543 -9.948 1.00 30.26 ? 547 LEU B CG 1 ATOM 3685 C CD1 . LEU A 1 491 ? 48.501 -35.472 -10.725 1.00 27.13 ? 547 LEU B CD1 1 ATOM 3686 C CD2 . LEU A 1 491 ? 50.781 -34.446 -10.592 1.00 26.20 ? 547 LEU B CD2 1 ATOM 3687 N N . LEU A 1 492 ? 48.211 -30.331 -7.827 1.00 42.96 ? 548 LEU B N 1 ATOM 3688 C CA . LEU A 1 492 ? 47.828 -28.926 -7.931 1.00 30.93 ? 548 LEU B CA 1 ATOM 3689 C C . LEU A 1 492 ? 48.846 -28.180 -7.094 1.00 22.75 ? 548 LEU B C 1 ATOM 3690 O O . LEU A 1 492 ? 48.715 -28.051 -5.884 1.00 21.79 ? 548 LEU B O 1 ATOM 3691 C CB . LEU A 1 492 ? 46.420 -28.715 -7.367 1.00 21.98 ? 548 LEU B CB 1 ATOM 3692 C CG . LEU A 1 492 ? 45.374 -29.703 -7.895 1.00 23.29 ? 548 LEU B CG 1 ATOM 3693 C CD1 . LEU A 1 492 ? 44.148 -29.755 -7.017 1.00 12.29 ? 548 LEU B CD1 1 ATOM 3694 C CD2 . LEU A 1 492 ? 44.986 -29.317 -9.301 1.00 26.01 ? 548 LEU B CD2 1 ATOM 3695 N N . THR A 1 493 ? 49.834 -27.634 -7.785 1.00 23.41 ? 549 THR B N 1 ATOM 3696 C CA . THR A 1 493 ? 51.039 -27.148 -7.149 1.00 23.47 ? 549 THR B CA 1 ATOM 3697 C C . THR A 1 493 ? 50.927 -25.671 -6.883 1.00 23.14 ? 549 THR B C 1 ATOM 3698 O O . THR A 1 493 ? 51.741 -25.092 -6.162 1.00 24.56 ? 549 THR B O 1 ATOM 3699 C CB . THR A 1 493 ? 52.252 -27.404 -8.058 1.00 32.10 ? 549 THR B CB 1 ATOM 3700 O OG1 . THR A 1 493 ? 52.224 -26.502 -9.175 1.00 30.33 ? 549 THR B OG1 1 ATOM 3701 C CG2 . THR A 1 493 ? 52.224 -28.830 -8.571 1.00 30.72 ? 549 THR B CG2 1 ATOM 3702 N N . GLU A 1 494 ? 49.917 -25.062 -7.493 1.00 23.16 ? 550 GLU B N 1 ATOM 3703 C CA . GLU A 1 494 ? 49.674 -23.639 -7.345 1.00 25.58 ? 550 GLU B CA 1 ATOM 3704 C C . GLU A 1 494 ? 48.584 -23.416 -6.323 1.00 23.40 ? 550 GLU B C 1 ATOM 3705 O O . GLU A 1 494 ? 48.252 -22.281 -6.014 1.00 27.52 ? 550 GLU B O 1 ATOM 3706 C CB . GLU A 1 494 ? 49.263 -23.034 -8.686 1.00 37.60 ? 550 GLU B CB 1 ATOM 3707 C CG . GLU A 1 494 ? 50.164 -23.447 -9.835 1.00 39.87 ? 550 GLU B CG 1 ATOM 3708 C CD . GLU A 1 494 ? 51.612 -23.171 -9.526 1.00 45.30 ? 550 GLU B CD 1 ATOM 3709 O OE1 . GLU A 1 494 ? 51.924 -22.002 -9.202 1.00 44.67 ? 550 GLU B OE1 1 ATOM 3710 O OE2 . GLU A 1 494 ? 52.429 -24.121 -9.584 1.00 47.46 ? 550 GLU B OE2 1 ATOM 3711 N N . LEU A 1 495 ? 48.024 -24.502 -5.802 1.00 22.38 ? 551 LEU B N 1 ATOM 3712 C CA . LEU A 1 495 ? 46.893 -24.394 -4.885 1.00 12.17 ? 551 LEU B CA 1 ATOM 3713 C C . LEU A 1 495 ? 47.306 -23.658 -3.624 1.00 22.59 ? 551 LEU B C 1 ATOM 3714 O O . LEU A 1 495 ? 48.434 -23.780 -3.163 1.00 37.46 ? 551 LEU B O 1 ATOM 3715 C CB . LEU A 1 495 ? 46.318 -25.769 -4.556 1.00 12.19 ? 551 LEU B CB 1 ATOM 3716 C CG . LEU A 1 495 ? 44.924 -25.780 -3.936 1.00 14.89 ? 551 LEU B CG 1 ATOM 3717 C CD1 . LEU A 1 495 ? 43.929 -25.050 -4.827 1.00 17.68 ? 551 LEU B CD1 1 ATOM 3718 C CD2 . LEU A 1 495 ? 44.464 -27.201 -3.687 1.00 11.33 ? 551 LEU B CD2 1 ATOM 3719 N N . THR A 1 496 ? 46.391 -22.878 -3.077 1.00 20.79 ? 552 THR B N 1 ATOM 3720 C CA . THR A 1 496 ? 46.709 -21.992 -1.962 1.00 21.92 ? 552 THR B CA 1 ATOM 3721 C C . THR A 1 496 ? 45.741 -22.197 -0.807 1.00 18.49 ? 552 THR B C 1 ATOM 3722 O O . THR A 1 496 ? 46.159 -22.402 0.329 1.00 15.06 ? 552 THR B O 1 ATOM 3723 C CB . THR A 1 496 ? 46.791 -20.533 -2.398 1.00 20.45 ? 552 THR B CB 1 ATOM 3724 O OG1 . THR A 1 496 ? 47.727 -20.438 -3.474 1.00 23.49 ? 552 THR B OG1 1 ATOM 3725 C CG2 . THR A 1 496 ? 47.287 -19.685 -1.266 1.00 28.06 ? 552 THR B CG2 1 ATOM 3726 N N . LYS A 1 497 ? 44.452 -22.039 -1.085 1.00 12.61 ? 553 LYS B N 1 ATOM 3727 C CA . LYS A 1 497 ? 43.434 -22.431 -0.123 1.00 15.68 ? 553 LYS B CA 1 ATOM 3728 C C . LYS A 1 497 ? 42.691 -23.662 -0.630 1.00 19.38 ? 553 LYS B C 1 ATOM 3729 O O . LYS A 1 497 ? 42.319 -23.736 -1.800 1.00 18.60 ? 553 LYS B O 1 ATOM 3730 C CB . LYS A 1 497 ? 42.481 -21.268 0.152 1.00 8.62 ? 553 LYS B CB 1 ATOM 3731 C CG . LYS A 1 497 ? 43.228 -20.030 0.600 1.00 8.71 ? 553 LYS B CG 1 ATOM 3732 C CD . LYS A 1 497 ? 42.353 -18.807 0.699 1.00 8.17 ? 553 LYS B CD 1 ATOM 3733 C CE . LYS A 1 497 ? 43.237 -17.581 0.814 1.00 12.65 ? 553 LYS B CE 1 ATOM 3734 N NZ . LYS A 1 497 ? 42.472 -16.315 0.917 1.00 13.68 ? 553 LYS B NZ 1 ATOM 3735 N N . LEU A 1 498 ? 42.525 -24.648 0.242 1.00 19.39 ? 554 LEU B N 1 ATOM 3736 C CA . LEU A 1 498 ? 41.744 -25.826 -0.089 1.00 9.17 ? 554 LEU B CA 1 ATOM 3737 C C . LEU A 1 498 ? 40.815 -26.169 1.058 1.00 10.26 ? 554 LEU B C 1 ATOM 3738 O O . LEU A 1 498 ? 41.258 -26.539 2.145 1.00 18.66 ? 554 LEU B O 1 ATOM 3739 C CB . LEU A 1 498 ? 42.644 -27.019 -0.399 1.00 9.97 ? 554 LEU B CB 1 ATOM 3740 C CG . LEU A 1 498 ? 41.944 -28.385 -0.403 1.00 22.42 ? 554 LEU B CG 1 ATOM 3741 C CD1 . LEU A 1 498 ? 40.797 -28.430 -1.417 1.00 17.34 ? 554 LEU B CD1 1 ATOM 3742 C CD2 . LEU A 1 498 ? 42.937 -29.504 -0.649 1.00 11.10 ? 554 LEU B CD2 1 ATOM 3743 N N . ASN A 1 499 ? 39.520 -26.070 0.795 1.00 8.36 ? 555 ASN B N 1 ATOM 3744 C CA . ASN A 1 499 ? 38.522 -26.345 1.802 1.00 16.30 ? 555 ASN B CA 1 ATOM 3745 C C . ASN A 1 499 ? 37.568 -27.458 1.370 1.00 14.69 ? 555 ASN B C 1 ATOM 3746 O O . ASN A 1 499 ? 36.791 -27.302 0.433 1.00 12.74 ? 555 ASN B O 1 ATOM 3747 C CB . ASN A 1 499 ? 37.768 -25.055 2.120 1.00 21.75 ? 555 ASN B CB 1 ATOM 3748 C CG . ASN A 1 499 ? 36.713 -25.245 3.167 1.00 24.04 ? 555 ASN B CG 1 ATOM 3749 O OD1 . ASN A 1 499 ? 36.729 -26.226 3.906 1.00 27.77 ? 555 ASN B OD1 1 ATOM 3750 N ND2 . ASN A 1 499 ? 35.773 -24.313 3.229 1.00 25.18 ? 555 ASN B ND2 1 ATOM 3751 N N . LEU A 1 500 ? 37.699 -28.601 2.028 1.00 22.45 ? 556 LEU B N 1 ATOM 3752 C CA . LEU A 1 500 ? 36.836 -29.761 1.846 1.00 8.12 ? 556 LEU B CA 1 ATOM 3753 C C . LEU A 1 500 ? 35.832 -30.003 2.948 1.00 11.72 ? 556 LEU B C 1 ATOM 3754 O O . LEU A 1 500 ? 35.202 -31.066 2.975 1.00 8.54 ? 556 LEU B O 1 ATOM 3755 C CB . LEU A 1 500 ? 37.672 -31.008 1.583 1.00 8.66 ? 556 LEU B CB 1 ATOM 3756 C CG . LEU A 1 500 ? 38.470 -30.741 0.305 1.00 17.60 ? 556 LEU B CG 1 ATOM 3757 C CD1 . LEU A 1 500 ? 39.561 -31.751 0.144 1.00 9.94 ? 556 LEU B CD1 1 ATOM 3758 C CD2 . LEU A 1 500 ? 37.554 -30.696 -0.926 1.00 8.66 ? 556 LEU B CD2 1 ATOM 3759 N N . ALA A 1 501 ? 35.742 -29.064 3.893 1.00 7.59 ? 557 ALA B N 1 ATOM 3760 C CA . ALA A 1 501 ? 34.976 -29.264 5.143 1.00 12.09 ? 557 ALA B CA 1 ATOM 3761 C C . ALA A 1 501 ? 33.498 -29.631 4.977 1.00 10.87 ? 557 ALA B C 1 ATOM 3762 O O . ALA A 1 501 ? 32.869 -29.325 3.965 1.00 8.96 ? 557 ALA B O 1 ATOM 3763 C CB . ALA A 1 501 ? 35.104 -28.064 6.063 1.00 7.20 ? 557 ALA B CB 1 ATOM 3764 N N . LYS A 1 502 ? 32.969 -30.331 5.973 1.00 11.63 ? 558 LYS B N 1 ATOM 3765 C CA . LYS A 1 502 ? 31.563 -30.729 5.988 1.00 13.10 ? 558 LYS B CA 1 ATOM 3766 C C . LYS A 1 502 ? 31.188 -31.538 4.739 1.00 13.19 ? 558 LYS B C 1 ATOM 3767 O O . LYS A 1 502 ? 30.386 -31.099 3.915 1.00 6.40 ? 558 LYS B O 1 ATOM 3768 C CB . LYS A 1 502 ? 30.664 -29.499 6.145 1.00 6.16 ? 558 LYS B CB 1 ATOM 3769 C CG . LYS A 1 502 ? 29.429 -29.736 6.970 1.00 15.13 ? 558 LYS B CG 1 ATOM 3770 C CD . LYS A 1 502 ? 28.420 -28.639 6.700 1.00 24.28 ? 558 LYS B CD 1 ATOM 3771 C CE . LYS A 1 502 ? 27.083 -28.850 7.438 1.00 29.36 ? 558 LYS B CE 1 ATOM 3772 N NZ . LYS A 1 502 ? 26.355 -30.106 7.073 1.00 29.11 ? 558 LYS B NZ 1 ATOM 3773 N N . ASN A 1 503 ? 31.801 -32.714 4.610 1.00 16.87 ? 559 ASN B N 1 ATOM 3774 C CA . ASN A 1 503 ? 31.487 -33.686 3.557 1.00 13.76 ? 559 ASN B CA 1 ATOM 3775 C C . ASN A 1 503 ? 31.445 -35.084 4.179 1.00 22.92 ? 559 ASN B C 1 ATOM 3776 O O . ASN A 1 503 ? 31.498 -35.233 5.414 1.00 27.92 ? 559 ASN B O 1 ATOM 3777 C CB . ASN A 1 503 ? 32.526 -33.654 2.421 1.00 13.45 ? 559 ASN B CB 1 ATOM 3778 C CG . ASN A 1 503 ? 32.277 -32.544 1.412 1.00 13.00 ? 559 ASN B CG 1 ATOM 3779 O OD1 . ASN A 1 503 ? 31.254 -32.521 0.747 1.00 19.61 ? 559 ASN B OD1 1 ATOM 3780 N ND2 . ASN A 1 503 ? 33.229 -31.640 1.276 1.00 7.59 ? 559 ASN B ND2 1 ATOM 3781 N N . ARG A 1 504 ? 31.313 -36.098 3.328 1.00 19.12 ? 560 ARG B N 1 ATOM 3782 C CA . ARG A 1 504 ? 31.405 -37.508 3.729 1.00 16.15 ? 560 ARG B CA 1 ATOM 3783 C C . ARG A 1 504 ? 32.770 -38.211 3.489 1.00 9.52 ? 560 ARG B C 1 ATOM 3784 O O . ARG A 1 504 ? 32.869 -39.432 3.602 1.00 10.20 ? 560 ARG B O 1 ATOM 3785 C CB . ARG A 1 504 ? 30.241 -38.295 3.132 1.00 15.21 ? 560 ARG B CB 1 ATOM 3786 C CG . ARG A 1 504 ? 28.909 -37.608 3.352 1.00 21.23 ? 560 ARG B CG 1 ATOM 3787 C CD . ARG A 1 504 ? 28.278 -37.984 4.692 1.00 41.12 ? 560 ARG B CD 1 ATOM 3788 N NE . ARG A 1 504 ? 29.072 -37.573 5.848 1.00 54.12 ? 560 ARG B NE 1 ATOM 3789 C CZ . ARG A 1 504 ? 29.632 -38.418 6.710 1.00 59.81 ? 560 ARG B CZ 1 ATOM 3790 N NH1 . ARG A 1 504 ? 29.478 -39.727 6.551 1.00 62.83 ? 560 ARG B NH1 1 ATOM 3791 N NH2 . ARG A 1 504 ? 30.338 -37.952 7.733 1.00 57.26 ? 560 ARG B NH2 1 ATOM 3792 N N . LEU A 1 505 ? 33.792 -37.445 3.111 1.00 9.60 ? 561 LEU B N 1 ATOM 3793 C CA . LEU A 1 505 ? 35.130 -37.970 2.804 1.00 18.64 ? 561 LEU B CA 1 ATOM 3794 C C . LEU A 1 505 ? 35.725 -38.854 3.912 1.00 22.97 ? 561 LEU B C 1 ATOM 3795 O O . LEU A 1 505 ? 35.515 -38.594 5.092 1.00 27.68 ? 561 LEU B O 1 ATOM 3796 C CB . LEU A 1 505 ? 36.087 -36.806 2.493 1.00 13.86 ? 561 LEU B CB 1 ATOM 3797 C CG . LEU A 1 505 ? 35.677 -35.833 1.377 1.00 16.54 ? 561 LEU B CG 1 ATOM 3798 C CD1 . LEU A 1 505 ? 36.464 -34.529 1.418 1.00 19.27 ? 561 LEU B CD1 1 ATOM 3799 C CD2 . LEU A 1 505 ? 35.872 -36.487 0.027 1.00 13.74 ? 561 LEU B CD2 1 ATOM 3800 N N . SER A 1 506 ? 36.465 -39.894 3.526 1.00 24.75 ? 562 SER B N 1 ATOM 3801 C CA . SER A 1 506 ? 37.051 -40.834 4.485 1.00 23.38 ? 562 SER B CA 1 ATOM 3802 C C . SER A 1 506 ? 38.417 -41.354 4.036 1.00 13.90 ? 562 SER B C 1 ATOM 3803 O O . SER A 1 506 ? 39.004 -40.854 3.081 1.00 40.41 ? 562 SER B O 1 ATOM 3804 C CB . SER A 1 506 ? 36.121 -42.022 4.711 1.00 22.67 ? 562 SER B CB 1 ATOM 3805 O OG . SER A 1 506 ? 36.436 -43.058 3.799 1.00 17.71 ? 562 SER B OG 1 ATOM 3806 N N . GLY A 1 507 ? 38.917 -42.363 4.746 1.00 26.79 ? 563 GLY B N 1 ATOM 3807 C CA . GLY A 1 507 ? 40.258 -42.876 4.542 1.00 15.67 ? 563 GLY B CA 1 ATOM 3808 C C . GLY A 1 507 ? 41.362 -42.020 5.149 1.00 22.40 ? 563 GLY B C 1 ATOM 3809 O O . GLY A 1 507 ? 41.099 -41.028 5.821 1.00 15.18 ? 563 GLY B O 1 ATOM 3810 N N . GLU A 1 508 ? 42.605 -42.425 4.914 1.00 16.74 ? 564 GLU B N 1 ATOM 3811 C CA . GLU A 1 508 ? 43.790 -41.694 5.340 1.00 22.65 ? 564 GLU B CA 1 ATOM 3812 C C . GLU A 1 508 ? 43.908 -40.386 4.587 1.00 27.51 ? 564 GLU B C 1 ATOM 3813 O O . GLU A 1 508 ? 43.342 -40.229 3.503 1.00 35.95 ? 564 GLU B O 1 ATOM 3814 C CB . GLU A 1 508 ? 45.033 -42.503 4.982 1.00 29.63 ? 564 GLU B CB 1 ATOM 3815 C CG . GLU A 1 508 ? 45.993 -42.778 6.098 1.00 34.51 ? 564 GLU B CG 1 ATOM 3816 C CD . GLU A 1 508 ? 45.712 -44.110 6.728 1.00 42.19 ? 564 GLU B CD 1 ATOM 3817 O OE1 . GLU A 1 508 ? 44.559 -44.564 6.591 1.00 34.61 ? 564 GLU B OE1 1 ATOM 3818 O OE2 . GLU A 1 508 ? 46.628 -44.701 7.347 1.00 52.68 ? 564 GLU B OE2 1 ATOM 3819 N N . ILE A 1 509 ? 44.662 -39.448 5.150 1.00 24.52 ? 565 ILE B N 1 ATOM 3820 C CA . ILE A 1 509 ? 45.168 -38.340 4.355 1.00 24.36 ? 565 ILE B CA 1 ATOM 3821 C C . ILE A 1 509 ? 46.362 -38.839 3.539 1.00 32.46 ? 565 ILE B C 1 ATOM 3822 O O . ILE A 1 509 ? 47.335 -39.334 4.109 1.00 45.21 ? 565 ILE B O 1 ATOM 3823 C CB . ILE A 1 509 ? 45.617 -37.172 5.230 1.00 22.64 ? 565 ILE B CB 1 ATOM 3824 C CG1 . ILE A 1 509 ? 44.417 -36.543 5.937 1.00 14.98 ? 565 ILE B CG1 1 ATOM 3825 C CG2 . ILE A 1 509 ? 46.385 -36.145 4.391 1.00 18.24 ? 565 ILE B CG2 1 ATOM 3826 C CD1 . ILE A 1 509 ? 44.761 -35.285 6.679 1.00 25.72 ? 565 ILE B CD1 1 ATOM 3827 N N . PRO A 1 510 ? 46.288 -38.723 2.205 1.00 29.89 ? 566 PRO B N 1 ATOM 3828 C CA . PRO A 1 510 ? 47.367 -39.172 1.321 1.00 34.56 ? 566 PRO B CA 1 ATOM 3829 C C . PRO A 1 510 ? 48.631 -38.375 1.564 1.00 34.38 ? 566 PRO B C 1 ATOM 3830 O O . PRO A 1 510 ? 48.547 -37.175 1.785 1.00 37.52 ? 566 PRO B O 1 ATOM 3831 C CB . PRO A 1 510 ? 46.821 -38.876 -0.086 1.00 38.89 ? 566 PRO B CB 1 ATOM 3832 C CG . PRO A 1 510 ? 45.833 -37.793 0.112 1.00 37.69 ? 566 PRO B CG 1 ATOM 3833 C CD . PRO A 1 510 ? 45.197 -38.080 1.454 1.00 36.70 ? 566 PRO B CD 1 ATOM 3834 N N . ARG A 1 511 ? 49.786 -39.027 1.510 1.00 34.12 ? 567 ARG B N 1 ATOM 3835 C CA . ARG A 1 511 ? 51.039 -38.374 1.860 1.00 31.43 ? 567 ARG B CA 1 ATOM 3836 C C . ARG A 1 511 ? 51.514 -37.400 0.790 1.00 36.66 ? 567 ARG B C 1 ATOM 3837 O O . ARG A 1 511 ? 52.409 -36.592 1.043 1.00 33.43 ? 567 ARG B O 1 ATOM 3838 C CB . ARG A 1 511 ? 52.114 -39.420 2.133 1.00 34.06 ? 567 ARG B CB 1 ATOM 3839 C CG . ARG A 1 511 ? 51.721 -40.427 3.188 1.00 41.31 ? 567 ARG B CG 1 ATOM 3840 C CD . ARG A 1 511 ? 52.678 -41.593 3.217 1.00 49.87 ? 567 ARG B CD 1 ATOM 3841 N NE . ARG A 1 511 ? 52.321 -42.525 4.276 1.00 54.97 ? 567 ARG B NE 1 ATOM 3842 C CZ . ARG A 1 511 ? 52.766 -42.431 5.522 1.00 57.93 ? 567 ARG B CZ 1 ATOM 3843 N NH1 . ARG A 1 511 ? 53.593 -41.448 5.857 1.00 54.05 ? 567 ARG B NH1 1 ATOM 3844 N NH2 . ARG A 1 511 ? 52.385 -43.321 6.432 1.00 65.56 ? 567 ARG B NH2 1 ATOM 3845 N N . GLU A 1 512 ? 50.910 -37.476 -0.399 1.00 42.07 ? 568 GLU B N 1 ATOM 3846 C CA . GLU A 1 512 ? 51.288 -36.609 -1.522 1.00 36.65 ? 568 GLU B CA 1 ATOM 3847 C C . GLU A 1 512 ? 50.839 -35.160 -1.363 1.00 38.52 ? 568 GLU B C 1 ATOM 3848 O O . GLU A 1 512 ? 51.133 -34.335 -2.212 1.00 42.17 ? 568 GLU B O 1 ATOM 3849 C CB . GLU A 1 512 ? 50.802 -37.153 -2.864 1.00 31.74 ? 568 GLU B CB 1 ATOM 3850 C CG . GLU A 1 512 ? 49.769 -38.246 -2.764 1.00 37.06 ? 568 GLU B CG 1 ATOM 3851 C CD . GLU A 1 512 ? 50.373 -39.623 -2.922 1.00 44.69 ? 568 GLU B CD 1 ATOM 3852 O OE1 . GLU A 1 512 ? 49.649 -40.625 -2.747 1.00 49.73 ? 568 GLU B OE1 1 ATOM 3853 O OE2 . GLU A 1 512 ? 51.578 -39.705 -3.221 1.00 44.52 ? 568 GLU B OE2 1 ATOM 3854 N N . ILE A 1 513 ? 50.109 -34.845 -0.297 1.00 35.31 ? 569 ILE B N 1 ATOM 3855 C CA . ILE A 1 513 ? 49.708 -33.458 -0.070 1.00 29.27 ? 569 ILE B CA 1 ATOM 3856 C C . ILE A 1 513 ? 50.952 -32.603 0.164 1.00 27.10 ? 569 ILE B C 1 ATOM 3857 O O . ILE A 1 513 ? 50.940 -31.392 -0.047 1.00 30.79 ? 569 ILE B O 1 ATOM 3858 C CB . ILE A 1 513 ? 48.699 -33.319 1.103 1.00 39.50 ? 569 ILE B CB 1 ATOM 3859 C CG1 . ILE A 1 513 ? 48.144 -31.892 1.196 1.00 32.62 ? 569 ILE B CG1 1 ATOM 3860 C CG2 . ILE A 1 513 ? 49.338 -33.726 2.416 1.00 43.15 ? 569 ILE B CG2 1 ATOM 3861 C CD1 . ILE A 1 513 ? 46.635 -31.828 1.305 1.00 14.45 ? 569 ILE B CD1 1 ATOM 3862 N N . SER A 1 514 ? 52.039 -33.252 0.563 1.00 22.47 ? 570 SER B N 1 ATOM 3863 C CA . SER A 1 514 ? 53.265 -32.543 0.885 1.00 28.42 ? 570 SER B CA 1 ATOM 3864 C C . SER A 1 514 ? 53.894 -31.987 -0.369 1.00 27.16 ? 570 SER B C 1 ATOM 3865 O O . SER A 1 514 ? 54.706 -31.064 -0.308 1.00 31.69 ? 570 SER B O 1 ATOM 3866 C CB . SER A 1 514 ? 54.247 -33.457 1.618 1.00 36.55 ? 570 SER B CB 1 ATOM 3867 O OG . SER A 1 514 ? 54.252 -34.746 1.034 1.00 43.55 ? 570 SER B OG 1 ATOM 3868 N N . THR A 1 515 ? 53.505 -32.529 -1.514 1.00 24.46 ? 571 THR B N 1 ATOM 3869 C CA . THR A 1 515 ? 53.992 -31.965 -2.776 1.00 32.79 ? 571 THR B CA 1 ATOM 3870 C C . THR A 1 515 ? 53.130 -30.836 -3.343 1.00 30.80 ? 571 THR B C 1 ATOM 3871 O O . THR A 1 515 ? 53.361 -30.402 -4.468 1.00 27.63 ? 571 THR B O 1 ATOM 3872 C CB . THR A 1 515 ? 54.336 -33.009 -3.885 1.00 20.98 ? 571 THR B CB 1 ATOM 3873 O OG1 . THR A 1 515 ? 54.945 -32.317 -4.975 1.00 27.51 ? 571 THR B OG1 1 ATOM 3874 C CG2 . THR A 1 515 ? 53.114 -33.732 -4.380 1.00 20.34 ? 571 THR B CG2 1 ATOM 3875 N N . CYS A 1 516 ? 52.139 -30.371 -2.580 1.00 33.11 ? 572 CYS B N 1 ATOM 3876 C CA . CYS A 1 516 ? 51.484 -29.120 -2.944 1.00 29.58 ? 572 CYS B CA 1 ATOM 3877 C C . CYS A 1 516 ? 52.276 -28.060 -2.221 1.00 34.36 ? 572 CYS B C 1 ATOM 3878 O O . CYS A 1 516 ? 52.054 -27.813 -1.038 1.00 40.87 ? 572 CYS B O 1 ATOM 3879 C CB . CYS A 1 516 ? 50.065 -29.037 -2.385 1.00 16.02 ? 572 CYS B CB 1 ATOM 3880 S SG . CYS A 1 516 ? 48.890 -30.301 -2.871 1.00 23.41 ? 572 CYS B SG 1 ATOM 3881 N N . ARG A 1 517 ? 53.114 -27.347 -2.956 1.00 35.31 ? 573 ARG B N 1 ATOM 3882 C CA . ARG A 1 517 ? 54.102 -26.489 -2.329 1.00 35.92 ? 573 ARG B CA 1 ATOM 3883 C C . ARG A 1 517 ? 53.590 -25.083 -2.006 1.00 29.89 ? 573 ARG B C 1 ATOM 3884 O O . ARG A 1 517 ? 54.240 -24.336 -1.273 1.00 36.33 ? 573 ARG B O 1 ATOM 3885 C CB . ARG A 1 517 ? 55.369 -26.443 -3.187 1.00 47.33 ? 573 ARG B CB 1 ATOM 3886 C CG . ARG A 1 517 ? 56.190 -27.734 -3.128 1.00 62.86 ? 573 ARG B CG 1 ATOM 3887 C CD . ARG A 1 517 ? 57.153 -27.752 -1.935 1.00 72.09 ? 573 ARG B CD 1 ATOM 3888 N NE . ARG A 1 517 ? 58.386 -27.011 -2.212 1.00 77.80 ? 573 ARG B NE 1 ATOM 3889 C CZ . ARG A 1 517 ? 59.317 -26.730 -1.303 1.00 79.82 ? 573 ARG B CZ 1 ATOM 3890 N NH1 . ARG A 1 517 ? 59.164 -27.116 -0.040 1.00 77.12 ? 573 ARG B NH1 1 ATOM 3891 N NH2 . ARG A 1 517 ? 60.403 -26.054 -1.657 1.00 81.73 ? 573 ARG B NH2 1 ATOM 3892 N N . SER A 1 518 ? 52.431 -24.728 -2.548 1.00 22.99 ? 574 SER B N 1 ATOM 3893 C CA . SER A 1 518 ? 51.907 -23.380 -2.378 1.00 18.30 ? 574 SER B CA 1 ATOM 3894 C C . SER A 1 518 ? 50.852 -23.226 -1.282 1.00 20.35 ? 574 SER B C 1 ATOM 3895 O O . SER A 1 518 ? 50.372 -22.115 -1.062 1.00 25.77 ? 574 SER B O 1 ATOM 3896 C CB . SER A 1 518 ? 51.357 -22.845 -3.707 1.00 18.44 ? 574 SER B CB 1 ATOM 3897 O OG . SER A 1 518 ? 52.370 -22.270 -4.522 1.00 21.05 ? 574 SER B OG 1 ATOM 3898 N N . LEU A 1 519 ? 50.517 -24.303 -0.570 1.00 14.78 ? 575 LEU B N 1 ATOM 3899 C CA . LEU A 1 519 ? 49.287 -24.329 0.241 1.00 15.87 ? 575 LEU B CA 1 ATOM 3900 C C . LEU A 1 519 ? 49.361 -23.467 1.504 1.00 20.36 ? 575 LEU B C 1 ATOM 3901 O O . LEU A 1 519 ? 50.195 -23.704 2.373 1.00 22.49 ? 575 LEU B O 1 ATOM 3902 C CB . LEU A 1 519 ? 48.986 -25.768 0.671 1.00 14.98 ? 575 LEU B CB 1 ATOM 3903 C CG . LEU A 1 519 ? 47.545 -26.278 0.755 1.00 15.26 ? 575 LEU B CG 1 ATOM 3904 C CD1 . LEU A 1 519 ? 46.939 -26.398 -0.632 1.00 13.45 ? 575 LEU B CD1 1 ATOM 3905 C CD2 . LEU A 1 519 ? 47.488 -27.627 1.461 1.00 20.85 ? 575 LEU B CD2 1 ATOM 3906 N N . GLN A 1 520 ? 48.499 -22.454 1.589 1.00 12.69 ? 576 GLN B N 1 ATOM 3907 C CA . GLN A 1 520 ? 48.384 -21.655 2.798 1.00 17.64 ? 576 GLN B CA 1 ATOM 3908 C C . GLN A 1 520 ? 47.220 -22.006 3.734 1.00 15.94 ? 576 GLN B C 1 ATOM 3909 O O . GLN A 1 520 ? 47.231 -21.638 4.908 1.00 19.74 ? 576 GLN B O 1 ATOM 3910 C CB . GLN A 1 520 ? 48.294 -20.186 2.410 1.00 13.59 ? 576 GLN B CB 1 ATOM 3911 C CG . GLN A 1 520 ? 49.480 -19.703 1.624 1.00 12.81 ? 576 GLN B CG 1 ATOM 3912 C CD . GLN A 1 520 ? 49.317 -18.263 1.207 1.00 25.53 ? 576 GLN B CD 1 ATOM 3913 O OE1 . GLN A 1 520 ? 48.417 -17.578 1.679 1.00 30.39 ? 576 GLN B OE1 1 ATOM 3914 N NE2 . GLN A 1 520 ? 50.174 -17.796 0.309 1.00 21.77 ? 576 GLN B NE2 1 ATOM 3915 N N . LEU A 1 521 ? 46.235 -22.731 3.222 1.00 11.11 ? 577 LEU B N 1 ATOM 3916 C CA . LEU A 1 521 ? 45.063 -23.092 4.009 1.00 10.40 ? 577 LEU B CA 1 ATOM 3917 C C . LEU A 1 521 ? 44.565 -24.471 3.634 1.00 10.44 ? 577 LEU B C 1 ATOM 3918 O O . LEU A 1 521 ? 44.356 -24.770 2.464 1.00 23.45 ? 577 LEU B O 1 ATOM 3919 C CB . LEU A 1 521 ? 43.935 -22.066 3.829 1.00 25.66 ? 577 LEU B CB 1 ATOM 3920 C CG . LEU A 1 521 ? 42.662 -22.222 4.684 1.00 20.59 ? 577 LEU B CG 1 ATOM 3921 C CD1 . LEU A 1 521 ? 42.196 -20.868 5.201 1.00 18.50 ? 577 LEU B CD1 1 ATOM 3922 C CD2 . LEU A 1 521 ? 41.526 -22.912 3.926 1.00 8.75 ? 577 LEU B CD2 1 ATOM 3923 N N . LEU A 1 522 ? 44.357 -25.302 4.640 1.00 21.28 ? 578 LEU B N 1 ATOM 3924 C CA . LEU A 1 522 ? 43.804 -26.620 4.432 1.00 21.75 ? 578 LEU B CA 1 ATOM 3925 C C . LEU A 1 522 ? 42.715 -26.812 5.470 1.00 19.21 ? 578 LEU B C 1 ATOM 3926 O O . LEU A 1 522 ? 43.006 -26.822 6.668 1.00 13.63 ? 578 LEU B O 1 ATOM 3927 C CB . LEU A 1 522 ? 44.901 -27.677 4.577 1.00 11.75 ? 578 LEU B CB 1 ATOM 3928 C CG . LEU A 1 522 ? 44.505 -29.153 4.574 1.00 41.91 ? 578 LEU B CG 1 ATOM 3929 C CD1 . LEU A 1 522 ? 43.717 -29.472 3.342 1.00 11.59 ? 578 LEU B CD1 1 ATOM 3930 C CD2 . LEU A 1 522 ? 45.729 -30.062 4.666 1.00 13.15 ? 578 LEU B CD2 1 ATOM 3931 N N . ASN A 1 523 ? 41.464 -26.927 5.015 1.00 18.00 ? 579 ASN B N 1 ATOM 3932 C CA . ASN A 1 523 ? 40.352 -27.266 5.901 1.00 17.95 ? 579 ASN B CA 1 ATOM 3933 C C . ASN A 1 523 ? 39.735 -28.618 5.545 1.00 17.58 ? 579 ASN B C 1 ATOM 3934 O O . ASN A 1 523 ? 39.018 -28.743 4.567 1.00 13.42 ? 579 ASN B O 1 ATOM 3935 C CB . ASN A 1 523 ? 39.293 -26.167 5.843 1.00 8.26 ? 579 ASN B CB 1 ATOM 3936 C CG . ASN A 1 523 ? 38.121 -26.421 6.772 1.00 7.91 ? 579 ASN B CG 1 ATOM 3937 O OD1 . ASN A 1 523 ? 38.091 -27.404 7.509 1.00 12.33 ? 579 ASN B OD1 1 ATOM 3938 N ND2 . ASN A 1 523 ? 37.142 -25.528 6.737 1.00 7.44 ? 579 ASN B ND2 1 ATOM 3939 N N . LEU A 1 524 ? 40.036 -29.624 6.357 1.00 22.63 ? 580 LEU B N 1 ATOM 3940 C CA . LEU A 1 524 ? 39.470 -30.960 6.224 1.00 9.70 ? 580 LEU B CA 1 ATOM 3941 C C . LEU A 1 524 ? 38.366 -31.259 7.237 1.00 25.37 ? 580 LEU B C 1 ATOM 3942 O O . LEU A 1 524 ? 37.932 -32.405 7.364 1.00 9.52 ? 580 LEU B O 1 ATOM 3943 C CB . LEU A 1 524 ? 40.569 -32.023 6.244 1.00 10.76 ? 580 LEU B CB 1 ATOM 3944 C CG . LEU A 1 524 ? 41.628 -31.796 5.161 1.00 11.25 ? 580 LEU B CG 1 ATOM 3945 C CD1 . LEU A 1 524 ? 42.701 -32.862 5.186 1.00 12.33 ? 580 LEU B CD1 1 ATOM 3946 C CD2 . LEU A 1 524 ? 40.971 -31.731 3.798 1.00 10.79 ? 580 LEU B CD2 1 ATOM 3947 N N . GLY A 1 525 ? 37.973 -30.239 8.002 1.00 8.69 ? 581 GLY B N 1 ATOM 3948 C CA . GLY A 1 525 ? 37.031 -30.387 9.104 1.00 8.34 ? 581 GLY B CA 1 ATOM 3949 C C . GLY A 1 525 ? 35.703 -31.064 8.803 1.00 23.58 ? 581 GLY B C 1 ATOM 3950 O O . GLY A 1 525 ? 35.177 -30.949 7.696 1.00 21.61 ? 581 GLY B O 1 ATOM 3951 N N . GLU A 1 526 ? 35.160 -31.774 9.791 1.00 24.38 ? 582 GLU B N 1 ATOM 3952 C CA . GLU A 1 526 ? 33.865 -32.439 9.648 1.00 7.70 ? 582 GLU B CA 1 ATOM 3953 C C . GLU A 1 526 ? 33.811 -33.399 8.460 1.00 14.75 ? 582 GLU B C 1 ATOM 3954 O O . GLU A 1 526 ? 33.117 -33.143 7.475 1.00 13.29 ? 582 GLU B O 1 ATOM 3955 C CB . GLU A 1 526 ? 32.762 -31.415 9.488 1.00 7.12 ? 582 GLU B CB 1 ATOM 3956 C CG . GLU A 1 526 ? 31.978 -31.132 10.720 1.00 15.44 ? 582 GLU B CG 1 ATOM 3957 C CD . GLU A 1 526 ? 30.669 -30.452 10.388 1.00 17.83 ? 582 GLU B CD 1 ATOM 3958 O OE1 . GLU A 1 526 ? 29.651 -31.178 10.298 1.00 12.46 ? 582 GLU B OE1 1 ATOM 3959 O OE2 . GLU A 1 526 ? 30.672 -29.208 10.198 1.00 17.89 ? 582 GLU B OE2 1 ATOM 3960 N N . ASN A 1 527 ? 34.545 -34.499 8.554 1.00 16.01 ? 583 ASN B N 1 ATOM 3961 C CA . ASN A 1 527 ? 34.452 -35.567 7.576 1.00 15.70 ? 583 ASN B CA 1 ATOM 3962 C C . ASN A 1 527 ? 34.630 -36.894 8.288 1.00 22.62 ? 583 ASN B C 1 ATOM 3963 O O . ASN A 1 527 ? 34.596 -36.954 9.523 1.00 23.93 ? 583 ASN B O 1 ATOM 3964 C CB . ASN A 1 527 ? 35.508 -35.417 6.486 1.00 17.11 ? 583 ASN B CB 1 ATOM 3965 C CG . ASN A 1 527 ? 35.161 -34.340 5.480 1.00 19.25 ? 583 ASN B CG 1 ATOM 3966 O OD1 . ASN A 1 527 ? 34.316 -34.546 4.624 1.00 20.84 ? 583 ASN B OD1 1 ATOM 3967 N ND2 . ASN A 1 527 ? 35.829 -33.192 5.565 1.00 20.19 ? 583 ASN B ND2 1 ATOM 3968 N N . ASP A 1 528 ? 34.777 -37.958 7.504 1.00 26.81 ? 584 ASP B N 1 ATOM 3969 C CA . ASP A 1 528 ? 35.038 -39.298 8.033 1.00 33.13 ? 584 ASP B CA 1 ATOM 3970 C C . ASP A 1 528 ? 36.508 -39.765 8.054 1.00 25.25 ? 584 ASP B C 1 ATOM 3971 O O . ASP A 1 528 ? 36.773 -40.964 8.167 1.00 28.27 ? 584 ASP B O 1 ATOM 3972 C CB . ASP A 1 528 ? 34.119 -40.349 7.412 1.00 46.65 ? 584 ASP B CB 1 ATOM 3973 C CG . ASP A 1 528 ? 33.744 -41.429 8.408 1.00 58.74 ? 584 ASP B CG 1 ATOM 3974 O OD1 . ASP A 1 528 ? 33.757 -41.124 9.626 1.00 56.65 ? 584 ASP B OD1 1 ATOM 3975 O OD2 . ASP A 1 528 ? 33.459 -42.572 7.983 1.00 64.34 ? 584 ASP B OD2 1 ATOM 3976 N N . PHE A 1 529 ? 37.448 -38.848 7.839 1.00 19.43 ? 585 PHE B N 1 ATOM 3977 C CA . PHE A 1 529 ? 38.865 -39.207 7.790 1.00 17.66 ? 585 PHE B CA 1 ATOM 3978 C C . PHE A 1 529 ? 39.312 -39.977 9.012 1.00 21.24 ? 585 PHE B C 1 ATOM 3979 O O . PHE A 1 529 ? 38.846 -39.736 10.126 1.00 13.49 ? 585 PHE B O 1 ATOM 3980 C CB . PHE A 1 529 ? 39.735 -37.960 7.710 1.00 15.09 ? 585 PHE B CB 1 ATOM 3981 C CG . PHE A 1 529 ? 39.655 -37.258 6.406 1.00 15.76 ? 585 PHE B CG 1 ATOM 3982 C CD1 . PHE A 1 529 ? 40.116 -37.870 5.254 1.00 13.08 ? 585 PHE B CD1 1 ATOM 3983 C CD2 . PHE A 1 529 ? 39.132 -35.983 6.329 1.00 17.01 ? 585 PHE B CD2 1 ATOM 3984 C CE1 . PHE A 1 529 ? 40.054 -37.234 4.065 1.00 12.72 ? 585 PHE B CE1 1 ATOM 3985 C CE2 . PHE A 1 529 ? 39.063 -35.338 5.128 1.00 16.41 ? 585 PHE B CE2 1 ATOM 3986 C CZ . PHE A 1 529 ? 39.520 -35.965 3.992 1.00 20.19 ? 585 PHE B CZ 1 ATOM 3987 N N . SER A 1 530 ? 40.235 -40.901 8.793 1.00 24.89 ? 586 SER B N 1 ATOM 3988 C CA . SER A 1 530 ? 40.726 -41.755 9.857 1.00 21.50 ? 586 SER B CA 1 ATOM 3989 C C . SER A 1 530 ? 42.200 -42.016 9.628 1.00 18.35 ? 586 SER B C 1 ATOM 3990 O O . SER A 1 530 ? 42.809 -41.442 8.720 1.00 18.72 ? 586 SER B O 1 ATOM 3991 C CB . SER A 1 530 ? 39.960 -43.075 9.865 1.00 29.50 ? 586 SER B CB 1 ATOM 3992 O OG . SER A 1 530 ? 39.966 -43.665 8.567 1.00 38.80 ? 586 SER B OG 1 ATOM 3993 N N . GLY A 1 531 ? 42.767 -42.889 10.456 1.00 17.15 ? 587 GLY B N 1 ATOM 3994 C CA . GLY A 1 531 ? 44.190 -43.166 10.420 1.00 19.53 ? 587 GLY B CA 1 ATOM 3995 C C . GLY A 1 531 ? 44.963 -42.109 11.184 1.00 21.75 ? 587 GLY B C 1 ATOM 3996 O O . GLY A 1 531 ? 44.378 -41.228 11.816 1.00 17.30 ? 587 GLY B O 1 ATOM 3997 N N . GLU A 1 532 ? 46.286 -42.200 11.128 1.00 21.33 ? 588 GLU B N 1 ATOM 3998 C CA . GLU A 1 532 ? 47.132 -41.234 11.797 1.00 25.20 ? 588 GLU B CA 1 ATOM 3999 C C . GLU A 1 532 ? 47.382 -40.074 10.861 1.00 21.64 ? 588 GLU B C 1 ATOM 4000 O O . GLU A 1 532 ? 47.548 -40.270 9.665 1.00 33.85 ? 588 GLU B O 1 ATOM 4001 C CB . GLU A 1 532 ? 48.462 -41.869 12.209 1.00 38.79 ? 588 GLU B CB 1 ATOM 4002 C CG . GLU A 1 532 ? 48.384 -42.819 13.406 1.00 40.98 ? 588 GLU B CG 1 ATOM 4003 C CD . GLU A 1 532 ? 49.723 -43.470 13.706 1.00 46.33 ? 588 GLU B CD 1 ATOM 4004 O OE1 . GLU A 1 532 ? 50.706 -43.152 13.000 1.00 54.00 ? 588 GLU B OE1 1 ATOM 4005 O OE2 . GLU A 1 532 ? 49.794 -44.302 14.636 1.00 43.50 ? 588 GLU B OE2 1 ATOM 4006 N N . ILE A 1 533 ? 47.379 -38.863 11.405 1.00 22.64 ? 589 ILE B N 1 ATOM 4007 C CA . ILE A 1 533 ? 47.773 -37.691 10.645 1.00 23.86 ? 589 ILE B CA 1 ATOM 4008 C C . ILE A 1 533 ? 49.186 -37.961 10.160 1.00 24.62 ? 589 ILE B C 1 ATOM 4009 O O . ILE A 1 533 ? 50.068 -38.251 10.960 1.00 27.13 ? 589 ILE B O 1 ATOM 4010 C CB . ILE A 1 533 ? 47.744 -36.404 11.503 1.00 24.11 ? 589 ILE B CB 1 ATOM 4011 C CG1 . ILE A 1 533 ? 46.404 -36.262 12.232 1.00 16.31 ? 589 ILE B CG1 1 ATOM 4012 C CG2 . ILE A 1 533 ? 47.993 -35.180 10.632 1.00 25.82 ? 589 ILE B CG2 1 ATOM 4013 C CD1 . ILE A 1 533 ? 46.365 -35.137 13.253 1.00 15.89 ? 589 ILE B CD1 1 ATOM 4014 N N . PRO A 1 534 ? 49.397 -37.901 8.839 1.00 21.71 ? 590 PRO B N 1 ATOM 4015 C CA . PRO A 1 534 ? 50.695 -38.296 8.287 1.00 24.61 ? 590 PRO B CA 1 ATOM 4016 C C . PRO A 1 534 ? 51.798 -37.302 8.624 1.00 35.57 ? 590 PRO B C 1 ATOM 4017 O O . PRO A 1 534 ? 51.552 -36.111 8.827 1.00 33.12 ? 590 PRO B O 1 ATOM 4018 C CB . PRO A 1 534 ? 50.444 -38.311 6.779 1.00 25.28 ? 590 PRO B CB 1 ATOM 4019 C CG . PRO A 1 534 ? 49.369 -37.306 6.582 1.00 30.71 ? 590 PRO B CG 1 ATOM 4020 C CD . PRO A 1 534 ? 48.472 -37.430 7.794 1.00 27.12 ? 590 PRO B CD 1 ATOM 4021 N N . ASP A 1 535 ? 53.017 -37.824 8.676 1.00 45.27 ? 591 ASP B N 1 ATOM 4022 C CA . ASP A 1 535 ? 54.214 -37.037 8.912 1.00 48.30 ? 591 ASP B CA 1 ATOM 4023 C C . ASP A 1 535 ? 54.382 -35.923 7.877 1.00 44.00 ? 591 ASP B C 1 ATOM 4024 O O . ASP A 1 535 ? 54.976 -34.887 8.166 1.00 45.21 ? 591 ASP B O 1 ATOM 4025 C CB . ASP A 1 535 ? 55.429 -37.961 8.873 1.00 58.07 ? 591 ASP B CB 1 ATOM 4026 C CG . ASP A 1 535 ? 56.669 -37.314 9.435 1.00 67.33 ? 591 ASP B CG 1 ATOM 4027 O OD1 . ASP A 1 535 ? 56.569 -36.699 10.520 1.00 75.48 ? 591 ASP B OD1 1 ATOM 4028 O OD2 . ASP A 1 535 ? 57.738 -37.419 8.796 1.00 64.66 ? 591 ASP B OD2 1 ATOM 4029 N N . GLU A 1 536 ? 53.853 -36.138 6.676 1.00 41.30 ? 592 GLU B N 1 ATOM 4030 C CA . GLU A 1 536 ? 54.055 -35.204 5.574 1.00 43.43 ? 592 GLU B CA 1 ATOM 4031 C C . GLU A 1 536 ? 53.255 -33.914 5.708 1.00 41.82 ? 592 GLU B C 1 ATOM 4032 O O . GLU A 1 536 ? 53.528 -32.936 5.019 1.00 42.01 ? 592 GLU B O 1 ATOM 4033 C CB . GLU A 1 536 ? 53.721 -35.864 4.236 1.00 48.01 ? 592 GLU B CB 1 ATOM 4034 C CG . GLU A 1 536 ? 54.649 -36.992 3.842 1.00 56.06 ? 592 GLU B CG 1 ATOM 4035 C CD . GLU A 1 536 ? 54.262 -38.307 4.483 1.00 65.19 ? 592 GLU B CD 1 ATOM 4036 O OE1 . GLU A 1 536 ? 53.372 -38.296 5.362 1.00 64.33 ? 592 GLU B OE1 1 ATOM 4037 O OE2 . GLU A 1 536 ? 54.838 -39.349 4.099 1.00 71.64 ? 592 GLU B OE2 1 ATOM 4038 N N . LEU A 1 537 ? 52.264 -33.903 6.587 1.00 39.81 ? 593 LEU B N 1 ATOM 4039 C CA . LEU A 1 537 ? 51.397 -32.734 6.690 1.00 30.65 ? 593 LEU B CA 1 ATOM 4040 C C . LEU A 1 537 ? 52.157 -31.531 7.210 1.00 29.67 ? 593 LEU B C 1 ATOM 4041 O O . LEU A 1 537 ? 51.770 -30.391 6.976 1.00 32.09 ? 593 LEU B O 1 ATOM 4042 C CB . LEU A 1 537 ? 50.194 -33.015 7.579 1.00 21.27 ? 593 LEU B CB 1 ATOM 4043 C CG . LEU A 1 537 ? 49.040 -32.041 7.386 1.00 23.03 ? 593 LEU B CG 1 ATOM 4044 C CD1 . LEU A 1 537 ? 48.953 -31.610 5.939 1.00 26.41 ? 593 LEU B CD1 1 ATOM 4045 C CD2 . LEU A 1 537 ? 47.749 -32.714 7.794 1.00 29.75 ? 593 LEU B CD2 1 ATOM 4046 N N . GLY A 1 538 ? 53.255 -31.785 7.905 1.00 32.69 ? 594 GLY B N 1 ATOM 4047 C CA . GLY A 1 538 ? 54.047 -30.702 8.434 1.00 36.55 ? 594 GLY B CA 1 ATOM 4048 C C . GLY A 1 538 ? 55.035 -30.210 7.413 1.00 41.95 ? 594 GLY B C 1 ATOM 4049 O O . GLY A 1 538 ? 55.883 -29.368 7.713 1.00 45.48 ? 594 GLY B O 1 ATOM 4050 N N . GLN A 1 539 ? 54.913 -30.709 6.192 1.00 49.53 ? 595 GLN B N 1 ATOM 4051 C CA . GLN A 1 539 ? 55.943 -30.438 5.202 1.00 57.18 ? 595 GLN B CA 1 ATOM 4052 C C . GLN A 1 539 ? 55.727 -29.290 4.207 1.00 52.08 ? 595 GLN B C 1 ATOM 4053 O O . GLN A 1 539 ? 56.603 -28.975 3.398 1.00 54.86 ? 595 GLN B O 1 ATOM 4054 C CB . GLN A 1 539 ? 56.431 -31.735 4.544 1.00 69.40 ? 595 GLN B CB 1 ATOM 4055 C CG . GLN A 1 539 ? 57.800 -32.117 5.044 1.00 80.61 ? 595 GLN B CG 1 ATOM 4056 C CD . GLN A 1 539 ? 58.461 -30.917 5.743 1.00 90.47 ? 595 GLN B CD 1 ATOM 4057 O OE1 . GLN A 1 539 ? 58.362 -30.763 6.962 1.00 93.47 ? 595 GLN B OE1 1 ATOM 4058 N NE2 . GLN A 1 539 ? 59.062 -30.025 4.956 1.00 94.35 ? 595 GLN B NE2 1 ATOM 4059 N N . ILE A 1 540 ? 54.588 -28.630 4.314 1.00 44.12 ? 596 ILE B N 1 ATOM 4060 C CA . ILE A 1 540 ? 54.374 -27.430 3.549 1.00 39.21 ? 596 ILE B CA 1 ATOM 4061 C C . ILE A 1 540 ? 54.795 -26.313 4.485 1.00 43.87 ? 596 ILE B C 1 ATOM 4062 O O . ILE A 1 540 ? 54.067 -25.979 5.418 1.00 39.97 ? 596 ILE B O 1 ATOM 4063 C CB . ILE A 1 540 ? 52.891 -27.317 3.172 1.00 34.05 ? 596 ILE B CB 1 ATOM 4064 C CG1 . ILE A 1 540 ? 52.336 -28.722 2.922 1.00 24.68 ? 596 ILE B CG1 1 ATOM 4065 C CG2 . ILE A 1 540 ? 52.699 -26.444 1.934 1.00 33.92 ? 596 ILE B CG2 1 ATOM 4066 C CD1 . ILE A 1 540 ? 50.850 -28.855 3.090 1.00 16.95 ? 596 ILE B CD1 1 ATOM 4067 N N . PRO A 1 541 ? 55.974 -25.713 4.234 1.00 55.12 ? 597 PRO B N 1 ATOM 4068 C CA . PRO A 1 541 ? 56.430 -24.614 5.095 1.00 54.69 ? 597 PRO B CA 1 ATOM 4069 C C . PRO A 1 541 ? 55.481 -23.452 4.872 1.00 47.98 ? 597 PRO B C 1 ATOM 4070 O O . PRO A 1 541 ? 55.411 -22.497 5.647 1.00 41.04 ? 597 PRO B O 1 ATOM 4071 C CB . PRO A 1 541 ? 57.819 -24.267 4.532 1.00 56.99 ? 597 PRO B CB 1 ATOM 4072 C CG . PRO A 1 541 ? 58.181 -25.384 3.602 1.00 59.59 ? 597 PRO B CG 1 ATOM 4073 C CD . PRO A 1 541 ? 56.889 -25.941 3.101 1.00 59.11 ? 597 PRO B CD 1 ATOM 4074 N N . SER A 1 542 ? 54.746 -23.574 3.773 1.00 47.67 ? 598 SER B N 1 ATOM 4075 C CA . SER A 1 542 ? 53.826 -22.568 3.285 1.00 37.53 ? 598 SER B CA 1 ATOM 4076 C C . SER A 1 542 ? 52.557 -22.423 4.131 1.00 27.85 ? 598 SER B C 1 ATOM 4077 O O . SER A 1 542 ? 51.887 -21.385 4.054 1.00 15.14 ? 598 SER B O 1 ATOM 4078 C CB . SER A 1 542 ? 53.460 -22.904 1.838 1.00 34.89 ? 598 SER B CB 1 ATOM 4079 O OG . SER A 1 542 ? 52.679 -21.882 1.262 1.00 41.49 ? 598 SER B OG 1 ATOM 4080 N N . LEU A 1 543 ? 52.232 -23.434 4.945 1.00 19.80 ? 599 LEU B N 1 ATOM 4081 C CA . LEU A 1 543 ? 50.974 -23.391 5.696 1.00 15.87 ? 599 LEU B CA 1 ATOM 4082 C C . LEU A 1 543 ? 51.070 -22.293 6.738 1.00 16.15 ? 599 LEU B C 1 ATOM 4083 O O . LEU A 1 543 ? 51.838 -22.380 7.692 1.00 22.47 ? 599 LEU B O 1 ATOM 4084 C CB . LEU A 1 543 ? 50.712 -24.721 6.404 1.00 15.93 ? 599 LEU B CB 1 ATOM 4085 C CG . LEU A 1 543 ? 49.918 -25.835 5.719 1.00 14.75 ? 599 LEU B CG 1 ATOM 4086 C CD1 . LEU A 1 543 ? 49.914 -27.085 6.587 1.00 38.07 ? 599 LEU B CD1 1 ATOM 4087 C CD2 . LEU A 1 543 ? 48.501 -25.385 5.439 1.00 13.56 ? 599 LEU B CD2 1 ATOM 4088 N N . ALA A 1 544 ? 50.218 -21.295 6.578 1.00 15.77 ? 600 ALA B N 1 ATOM 4089 C CA . ALA A 1 544 ? 50.355 -20.034 7.286 1.00 22.65 ? 600 ALA B CA 1 ATOM 4090 C C . ALA A 1 544 ? 49.035 -19.682 7.919 1.00 22.26 ? 600 ALA B C 1 ATOM 4091 O O . ALA A 1 544 ? 48.944 -19.423 9.120 1.00 19.10 ? 600 ALA B O 1 ATOM 4092 C CB . ALA A 1 544 ? 50.801 -18.942 6.353 1.00 30.62 ? 600 ALA B CB 1 ATOM 4093 N N . ILE A 1 545 ? 48.016 -19.618 7.072 1.00 19.47 ? 601 ILE B N 1 ATOM 4094 C CA . ILE A 1 545 ? 46.715 -19.119 7.476 1.00 21.84 ? 601 ILE B CA 1 ATOM 4095 C C . ILE A 1 545 ? 45.990 -20.061 8.431 1.00 23.17 ? 601 ILE B C 1 ATOM 4096 O O . ILE A 1 545 ? 45.700 -19.682 9.569 1.00 21.42 ? 601 ILE B O 1 ATOM 4097 C CB . ILE A 1 545 ? 45.818 -18.883 6.259 1.00 19.57 ? 601 ILE B CB 1 ATOM 4098 C CG1 . ILE A 1 545 ? 46.570 -18.069 5.200 1.00 16.90 ? 601 ILE B CG1 1 ATOM 4099 C CG2 . ILE A 1 545 ? 44.531 -18.213 6.691 1.00 8.97 ? 601 ILE B CG2 1 ATOM 4100 C CD1 . ILE A 1 545 ? 45.797 -17.881 3.903 1.00 14.88 ? 601 ILE B CD1 1 ATOM 4101 N N . SER A 1 546 ? 45.661 -21.266 7.968 1.00 21.38 ? 602 SER B N 1 ATOM 4102 C CA . SER A 1 546 ? 44.887 -22.176 8.804 1.00 20.97 ? 602 SER B CA 1 ATOM 4103 C C . SER A 1 546 ? 45.072 -23.673 8.508 1.00 20.34 ? 602 SER B C 1 ATOM 4104 O O . SER A 1 546 ? 45.328 -24.070 7.377 1.00 11.01 ? 602 SER B O 1 ATOM 4105 C CB . SER A 1 546 ? 43.407 -21.793 8.730 1.00 30.45 ? 602 SER B CB 1 ATOM 4106 O OG . SER A 1 546 ? 42.577 -22.826 9.221 1.00 41.15 ? 602 SER B OG 1 ATOM 4107 N N . LEU A 1 547 ? 44.971 -24.495 9.552 1.00 19.40 ? 603 LEU B N 1 ATOM 4108 C CA . LEU A 1 547 ? 44.867 -25.946 9.391 1.00 15.62 ? 603 LEU B CA 1 ATOM 4109 C C . LEU A 1 547 ? 43.772 -26.467 10.312 1.00 17.83 ? 603 LEU B C 1 ATOM 4110 O O . LEU A 1 547 ? 43.937 -26.482 11.526 1.00 21.58 ? 603 LEU B O 1 ATOM 4111 C CB . LEU A 1 547 ? 46.205 -26.624 9.735 1.00 14.62 ? 603 LEU B CB 1 ATOM 4112 C CG . LEU A 1 547 ? 46.368 -28.148 9.624 1.00 13.10 ? 603 LEU B CG 1 ATOM 4113 C CD1 . LEU A 1 547 ? 46.012 -28.675 8.217 1.00 12.96 ? 603 LEU B CD1 1 ATOM 4114 C CD2 . LEU A 1 547 ? 47.794 -28.558 10.024 1.00 14.23 ? 603 LEU B CD2 1 ATOM 4115 N N . ASN A 1 548 ? 42.675 -26.929 9.724 1.00 21.38 ? 604 ASN B N 1 ATOM 4116 C CA . ASN A 1 548 ? 41.539 -27.443 10.477 1.00 17.63 ? 604 ASN B CA 1 ATOM 4117 C C . ASN A 1 548 ? 41.372 -28.922 10.152 1.00 27.16 ? 604 ASN B C 1 ATOM 4118 O O . ASN A 1 548 ? 40.955 -29.290 9.048 1.00 40.12 ? 604 ASN B O 1 ATOM 4119 C CB . ASN A 1 548 ? 40.292 -26.649 10.071 1.00 13.55 ? 604 ASN B CB 1 ATOM 4120 C CG . ASN A 1 548 ? 39.068 -26.988 10.890 1.00 15.92 ? 604 ASN B CG 1 ATOM 4121 O OD1 . ASN A 1 548 ? 38.972 -28.065 11.476 1.00 18.16 ? 604 ASN B OD1 1 ATOM 4122 N ND2 . ASN A 1 548 ? 38.101 -26.065 10.908 1.00 7.97 ? 604 ASN B ND2 1 ATOM 4123 N N . LEU A 1 549 ? 41.759 -29.762 11.102 1.00 21.63 ? 605 LEU B N 1 ATOM 4124 C CA . LEU A 1 549 ? 41.559 -31.206 11.038 1.00 11.30 ? 605 LEU B CA 1 ATOM 4125 C C . LEU A 1 549 ? 40.385 -31.657 11.907 1.00 11.44 ? 605 LEU B C 1 ATOM 4126 O O . LEU A 1 549 ? 40.214 -32.840 12.183 1.00 11.29 ? 605 LEU B O 1 ATOM 4127 C CB . LEU A 1 549 ? 42.848 -31.946 11.379 1.00 12.36 ? 605 LEU B CB 1 ATOM 4128 C CG . LEU A 1 549 ? 43.949 -31.746 10.335 1.00 12.87 ? 605 LEU B CG 1 ATOM 4129 C CD1 . LEU A 1 549 ? 45.271 -32.332 10.806 1.00 13.95 ? 605 LEU B CD1 1 ATOM 4130 C CD2 . LEU A 1 549 ? 43.529 -32.357 9.006 1.00 12.78 ? 605 LEU B CD2 1 ATOM 4131 N N . SER A 1 550 ? 39.629 -30.694 12.412 1.00 10.15 ? 606 SER B N 1 ATOM 4132 C CA . SER A 1 550 ? 38.631 -30.971 13.435 1.00 22.52 ? 606 SER B CA 1 ATOM 4133 C C . SER A 1 550 ? 37.511 -31.889 12.948 1.00 24.55 ? 606 SER B C 1 ATOM 4134 O O . SER A 1 550 ? 37.333 -32.094 11.737 1.00 22.04 ? 606 SER B O 1 ATOM 4135 C CB . SER A 1 550 ? 38.019 -29.672 13.940 1.00 9.08 ? 606 SER B CB 1 ATOM 4136 O OG . SER A 1 550 ? 37.000 -29.244 13.060 1.00 8.29 ? 606 SER B OG 1 ATOM 4137 N N . CYS A 1 551 ? 36.794 -32.471 13.908 1.00 21.11 ? 607 CYS B N 1 ATOM 4138 C CA . CYS A 1 551 ? 35.611 -33.290 13.633 1.00 9.30 ? 607 CYS B CA 1 ATOM 4139 C C . CYS A 1 551 ? 35.820 -34.424 12.616 1.00 17.24 ? 607 CYS B C 1 ATOM 4140 O O . CYS A 1 551 ? 35.018 -34.630 11.711 1.00 13.70 ? 607 CYS B O 1 ATOM 4141 C CB . CYS A 1 551 ? 34.439 -32.410 13.231 1.00 8.34 ? 607 CYS B CB 1 ATOM 4142 S SG . CYS A 1 551 ? 34.130 -31.097 14.415 1.00 15.23 ? 607 CYS B SG 1 ATOM 4143 N N . ASN A 1 552 ? 36.902 -35.167 12.798 1.00 10.63 ? 608 ASN B N 1 ATOM 4144 C CA . ASN A 1 552 ? 37.108 -36.416 12.101 1.00 11.22 ? 608 ASN B CA 1 ATOM 4145 C C . ASN A 1 552 ? 37.348 -37.552 13.095 1.00 30.40 ? 608 ASN B C 1 ATOM 4146 O O . ASN A 1 552 ? 37.120 -37.410 14.302 1.00 25.14 ? 608 ASN B O 1 ATOM 4147 C CB . ASN A 1 552 ? 38.289 -36.306 11.143 1.00 20.28 ? 608 ASN B CB 1 ATOM 4148 C CG . ASN A 1 552 ? 38.014 -35.379 10.004 1.00 18.59 ? 608 ASN B CG 1 ATOM 4149 O OD1 . ASN A 1 552 ? 37.204 -35.681 9.135 1.00 11.60 ? 608 ASN B OD1 1 ATOM 4150 N ND2 . ASN A 1 552 ? 38.682 -34.236 9.994 1.00 28.07 ? 608 ASN B ND2 1 ATOM 4151 N N . ARG A 1 553 ? 37.742 -38.699 12.562 1.00 27.26 ? 609 ARG B N 1 ATOM 4152 C CA . ARG A 1 553 ? 38.138 -39.854 13.355 1.00 22.94 ? 609 ARG B CA 1 ATOM 4153 C C . ARG A 1 553 ? 39.648 -40.072 13.583 1.00 25.07 ? 609 ARG B C 1 ATOM 4154 O O . ARG A 1 553 ? 40.055 -41.158 13.992 1.00 36.79 ? 609 ARG B O 1 ATOM 4155 C CB . ARG A 1 553 ? 37.400 -41.113 12.906 1.00 24.36 ? 609 ARG B CB 1 ATOM 4156 C CG . ARG A 1 553 ? 35.924 -41.038 13.268 1.00 26.27 ? 609 ARG B CG 1 ATOM 4157 C CD . ARG A 1 553 ? 35.163 -42.287 12.897 1.00 31.23 ? 609 ARG B CD 1 ATOM 4158 N NE . ARG A 1 553 ? 35.138 -42.508 11.457 1.00 35.55 ? 609 ARG B NE 1 ATOM 4159 C CZ . ARG A 1 553 ? 35.726 -43.535 10.853 1.00 43.91 ? 609 ARG B CZ 1 ATOM 4160 N NH1 . ARG A 1 553 ? 36.383 -44.439 11.574 1.00 38.77 ? 609 ARG B NH1 1 ATOM 4161 N NH2 . ARG A 1 553 ? 35.653 -43.661 9.528 1.00 50.86 ? 609 ARG B NH2 1 ATOM 4162 N N . PHE A 1 554 ? 40.474 -39.077 13.266 1.00 22.31 ? 610 PHE B N 1 ATOM 4163 C CA . PHE A 1 554 ? 41.933 -39.215 13.406 1.00 25.52 ? 610 PHE B CA 1 ATOM 4164 C C . PHE A 1 554 ? 42.364 -39.794 14.755 1.00 24.66 ? 610 PHE B C 1 ATOM 4165 O O . PHE A 1 554 ? 41.828 -39.437 15.811 1.00 15.34 ? 610 PHE B O 1 ATOM 4166 C CB . PHE A 1 554 ? 42.644 -37.857 13.234 1.00 26.54 ? 610 PHE B CB 1 ATOM 4167 C CG . PHE A 1 554 ? 42.498 -37.246 11.864 1.00 29.04 ? 610 PHE B CG 1 ATOM 4168 C CD1 . PHE A 1 554 ? 43.039 -37.872 10.741 1.00 31.48 ? 610 PHE B CD1 1 ATOM 4169 C CD2 . PHE A 1 554 ? 41.843 -36.031 11.697 1.00 23.82 ? 610 PHE B CD2 1 ATOM 4170 C CE1 . PHE A 1 554 ? 42.915 -37.311 9.478 1.00 14.53 ? 610 PHE B CE1 1 ATOM 4171 C CE2 . PHE A 1 554 ? 41.720 -35.460 10.431 1.00 19.39 ? 610 PHE B CE2 1 ATOM 4172 C CZ . PHE A 1 554 ? 42.263 -36.103 9.325 1.00 13.61 ? 610 PHE B CZ 1 ATOM 4173 N N . VAL A 1 555 ? 43.331 -40.705 14.701 1.00 25.90 ? 611 VAL B N 1 ATOM 4174 C CA . VAL A 1 555 ? 43.951 -41.244 15.905 1.00 22.02 ? 611 VAL B CA 1 ATOM 4175 C C . VAL A 1 555 ? 45.471 -41.077 15.876 1.00 19.13 ? 611 VAL B C 1 ATOM 4176 O O . VAL A 1 555 ? 46.043 -40.564 14.911 1.00 20.85 ? 611 VAL B O 1 ATOM 4177 C CB . VAL A 1 555 ? 43.615 -42.732 16.114 1.00 17.87 ? 611 VAL B CB 1 ATOM 4178 C CG1 . VAL A 1 555 ? 42.110 -42.937 16.263 1.00 17.18 ? 611 VAL B CG1 1 ATOM 4179 C CG2 . VAL A 1 555 ? 44.165 -43.556 14.980 1.00 18.49 ? 611 VAL B CG2 1 ATOM 4180 N N . GLY A 1 556 ? 46.122 -41.512 16.949 1.00 18.77 ? 612 GLY B N 1 ATOM 4181 C CA . GLY A 1 556 ? 47.557 -41.379 17.073 1.00 19.57 ? 612 GLY B CA 1 ATOM 4182 C C . GLY A 1 556 ? 47.937 -40.051 17.688 1.00 19.26 ? 612 GLY B C 1 ATOM 4183 O O . GLY A 1 556 ? 47.090 -39.313 18.166 1.00 19.55 ? 612 GLY B O 1 ATOM 4184 N N . GLU A 1 557 ? 49.223 -39.739 17.646 1.00 19.92 ? 613 GLU B N 1 ATOM 4185 C CA . GLU A 1 557 ? 49.745 -38.525 18.241 1.00 24.30 ? 613 GLU B CA 1 ATOM 4186 C C . GLU A 1 557 ? 49.957 -37.461 17.177 1.00 19.40 ? 613 GLU B C 1 ATOM 4187 O O . GLU A 1 557 ? 50.198 -37.775 16.022 1.00 47.17 ? 613 GLU B O 1 ATOM 4188 C CB . GLU A 1 557 ? 51.078 -38.799 18.950 1.00 27.69 ? 613 GLU B CB 1 ATOM 4189 C CG . GLU A 1 557 ? 51.023 -39.818 20.074 1.00 30.06 ? 613 GLU B CG 1 ATOM 4190 C CD . GLU A 1 557 ? 52.349 -39.935 20.812 1.00 36.16 ? 613 GLU B CD 1 ATOM 4191 O OE1 . GLU A 1 557 ? 53.285 -39.178 20.478 1.00 31.90 ? 613 GLU B OE1 1 ATOM 4192 O OE2 . GLU A 1 557 ? 52.455 -40.778 21.731 1.00 44.49 ? 613 GLU B OE2 1 ATOM 4193 N N . ILE A 1 558 ? 49.822 -36.203 17.570 1.00 34.65 ? 614 ILE B N 1 ATOM 4194 C CA . ILE A 1 558 ? 50.214 -35.100 16.715 1.00 29.99 ? 614 ILE B CA 1 ATOM 4195 C C . ILE A 1 558 ? 51.628 -35.367 16.246 1.00 27.01 ? 614 ILE B C 1 ATOM 4196 O O . ILE A 1 558 ? 52.526 -35.550 17.064 1.00 28.68 ? 614 ILE B O 1 ATOM 4197 C CB . ILE A 1 558 ? 50.170 -33.765 17.482 1.00 27.53 ? 614 ILE B CB 1 ATOM 4198 C CG1 . ILE A 1 558 ? 48.723 -33.297 17.629 1.00 22.16 ? 614 ILE B CG1 1 ATOM 4199 C CG2 . ILE A 1 558 ? 50.995 -32.701 16.772 1.00 28.81 ? 614 ILE B CG2 1 ATOM 4200 C CD1 . ILE A 1 558 ? 48.572 -32.065 18.458 1.00 17.53 ? 614 ILE B CD1 1 ATOM 4201 N N . PRO A 1 559 ? 51.823 -35.418 14.917 1.00 27.54 ? 615 PRO B N 1 ATOM 4202 C CA . PRO A 1 559 ? 53.112 -35.769 14.307 1.00 25.86 ? 615 PRO B CA 1 ATOM 4203 C C . PRO A 1 559 ? 54.227 -34.771 14.622 1.00 28.88 ? 615 PRO B C 1 ATOM 4204 O O . PRO A 1 559 ? 53.983 -33.587 14.819 1.00 27.45 ? 615 PRO B O 1 ATOM 4205 C CB . PRO A 1 559 ? 52.796 -35.792 12.809 1.00 20.43 ? 615 PRO B CB 1 ATOM 4206 C CG . PRO A 1 559 ? 51.574 -34.977 12.668 1.00 19.25 ? 615 PRO B CG 1 ATOM 4207 C CD . PRO A 1 559 ? 50.782 -35.175 13.905 1.00 24.36 ? 615 PRO B CD 1 ATOM 4208 N N . SER A 1 560 ? 55.457 -35.267 14.663 1.00 37.35 ? 616 SER B N 1 ATOM 4209 C CA . SER A 1 560 ? 56.601 -34.474 15.094 1.00 32.30 ? 616 SER B CA 1 ATOM 4210 C C . SER A 1 560 ? 56.950 -33.350 14.128 1.00 37.51 ? 616 SER B C 1 ATOM 4211 O O . SER A 1 560 ? 57.247 -32.238 14.568 1.00 39.02 ? 616 SER B O 1 ATOM 4212 C CB . SER A 1 560 ? 57.804 -35.385 15.310 1.00 27.63 ? 616 SER B CB 1 ATOM 4213 O OG . SER A 1 560 ? 57.377 -36.630 15.839 1.00 26.16 ? 616 SER B OG 1 ATOM 4214 N N . ARG A 1 561 ? 56.888 -33.626 12.821 1.00 38.53 ? 617 ARG B N 1 ATOM 4215 C CA . ARG A 1 561 ? 57.206 -32.619 11.802 1.00 34.05 ? 617 ARG B CA 1 ATOM 4216 C C . ARG A 1 561 ? 56.292 -31.386 11.912 1.00 39.94 ? 617 ARG B C 1 ATOM 4217 O O . ARG A 1 561 ? 56.546 -30.364 11.282 1.00 49.57 ? 617 ARG B O 1 ATOM 4218 C CB . ARG A 1 561 ? 57.137 -33.207 10.383 1.00 38.09 ? 617 ARG B CB 1 ATOM 4219 C CG . ARG A 1 561 ? 58.293 -34.118 9.994 1.00 52.41 ? 617 ARG B CG 1 ATOM 4220 C CD . ARG A 1 561 ? 59.418 -33.352 9.275 1.00 61.13 ? 617 ARG B CD 1 ATOM 4221 N NE . ARG A 1 561 ? 59.514 -33.720 7.860 1.00 72.69 ? 617 ARG B NE 1 ATOM 4222 C CZ . ARG A 1 561 ? 60.485 -33.328 7.039 1.00 83.57 ? 617 ARG B CZ 1 ATOM 4223 N NH1 . ARG A 1 561 ? 61.455 -32.547 7.494 1.00 92.08 ? 617 ARG B NH1 1 ATOM 4224 N NH2 . ARG A 1 561 ? 60.486 -33.732 5.773 1.00 81.60 ? 617 ARG B NH2 1 ATOM 4225 N N . PHE A 1 562 ? 55.229 -31.489 12.710 1.00 36.27 ? 618 PHE B N 1 ATOM 4226 C CA . PHE A 1 562 ? 54.322 -30.364 12.952 1.00 33.75 ? 618 PHE B CA 1 ATOM 4227 C C . PHE A 1 562 ? 55.050 -29.142 13.493 1.00 38.53 ? 618 PHE B C 1 ATOM 4228 O O . PHE A 1 562 ? 54.671 -28.011 13.196 1.00 43.56 ? 618 PHE B O 1 ATOM 4229 C CB . PHE A 1 562 ? 53.213 -30.756 13.930 1.00 30.46 ? 618 PHE B CB 1 ATOM 4230 C CG . PHE A 1 562 ? 51.867 -30.928 13.289 1.00 30.12 ? 618 PHE B CG 1 ATOM 4231 C CD1 . PHE A 1 562 ? 51.721 -31.675 12.134 1.00 27.57 ? 618 PHE B CD1 1 ATOM 4232 C CD2 . PHE A 1 562 ? 50.741 -30.354 13.855 1.00 25.26 ? 618 PHE B CD2 1 ATOM 4233 C CE1 . PHE A 1 562 ? 50.482 -31.841 11.552 1.00 23.74 ? 618 PHE B CE1 1 ATOM 4234 C CE2 . PHE A 1 562 ? 49.497 -30.516 13.272 1.00 24.13 ? 618 PHE B CE2 1 ATOM 4235 C CZ . PHE A 1 562 ? 49.370 -31.261 12.120 1.00 16.34 ? 618 PHE B CZ 1 ATOM 4236 N N . SER A 1 563 ? 56.099 -29.373 14.279 1.00 39.82 ? 619 SER B N 1 ATOM 4237 C CA . SER A 1 563 ? 56.890 -28.286 14.851 1.00 37.67 ? 619 SER B CA 1 ATOM 4238 C C . SER A 1 563 ? 57.538 -27.463 13.742 1.00 39.36 ? 619 SER B C 1 ATOM 4239 O O . SER A 1 563 ? 57.996 -26.341 13.975 1.00 40.28 ? 619 SER B O 1 ATOM 4240 C CB . SER A 1 563 ? 57.967 -28.837 15.787 1.00 35.70 ? 619 SER B CB 1 ATOM 4241 O OG . SER A 1 563 ? 58.961 -29.543 15.059 1.00 37.53 ? 619 SER B OG 1 ATOM 4242 N N . ASP A 1 564 ? 57.573 -28.033 12.537 1.00 32.30 ? 620 ASP B N 1 ATOM 4243 C CA . ASP A 1 564 ? 58.069 -27.328 11.370 1.00 29.73 ? 620 ASP B CA 1 ATOM 4244 C C . ASP A 1 564 ? 57.032 -26.398 10.779 1.00 30.58 ? 620 ASP B C 1 ATOM 4245 O O . ASP A 1 564 ? 57.347 -25.649 9.847 1.00 35.18 ? 620 ASP B O 1 ATOM 4246 C CB . ASP A 1 564 ? 58.516 -28.291 10.270 1.00 32.66 ? 620 ASP B CB 1 ATOM 4247 C CG . ASP A 1 564 ? 59.740 -29.074 10.649 1.00 38.74 ? 620 ASP B CG 1 ATOM 4248 O OD1 . ASP A 1 564 ? 60.317 -28.793 11.726 1.00 33.61 ? 620 ASP B OD1 1 ATOM 4249 O OD2 . ASP A 1 564 ? 60.124 -29.966 9.858 1.00 43.79 ? 620 ASP B OD2 1 ATOM 4250 N N . LEU A 1 565 ? 55.803 -26.410 11.285 1.00 25.64 ? 621 LEU B N 1 ATOM 4251 C CA . LEU A 1 565 ? 54.886 -25.456 10.702 1.00 27.71 ? 621 LEU B CA 1 ATOM 4252 C C . LEU A 1 565 ? 55.116 -24.245 11.563 1.00 30.23 ? 621 LEU B C 1 ATOM 4253 O O . LEU A 1 565 ? 54.397 -23.992 12.526 1.00 29.07 ? 621 LEU B O 1 ATOM 4254 C CB . LEU A 1 565 ? 53.441 -25.941 10.853 1.00 25.22 ? 621 LEU B CB 1 ATOM 4255 C CG . LEU A 1 565 ? 53.123 -27.301 10.229 1.00 23.47 ? 621 LEU B CG 1 ATOM 4256 C CD1 . LEU A 1 565 ? 51.844 -27.926 10.795 1.00 20.73 ? 621 LEU B CD1 1 ATOM 4257 C CD2 . LEU A 1 565 ? 53.035 -27.158 8.725 1.00 21.31 ? 621 LEU B CD2 1 ATOM 4258 N N . LYS A 1 566 ? 56.044 -23.420 11.103 1.00 35.10 ? 622 LYS B N 1 ATOM 4259 C CA . LYS A 1 566 ? 56.527 -22.308 11.892 1.00 36.71 ? 622 LYS B CA 1 ATOM 4260 C C . LYS A 1 566 ? 55.726 -21.075 11.537 1.00 37.01 ? 622 LYS B C 1 ATOM 4261 O O . LYS A 1 566 ? 55.724 -20.093 12.268 1.00 39.84 ? 622 LYS B O 1 ATOM 4262 C CB . LYS A 1 566 ? 58.015 -22.084 11.603 1.00 48.27 ? 622 LYS B CB 1 ATOM 4263 C CG . LYS A 1 566 ? 58.329 -21.853 10.106 1.00 57.42 ? 622 LYS B CG 1 ATOM 4264 C CD . LYS A 1 566 ? 59.837 -21.714 9.835 1.00 57.22 ? 622 LYS B CD 1 ATOM 4265 C CE . LYS A 1 566 ? 60.127 -21.366 8.373 1.00 48.42 ? 622 LYS B CE 1 ATOM 4266 N NZ . LYS A 1 566 ? 61.592 -21.272 8.111 1.00 47.36 ? 622 LYS B NZ 1 ATOM 4267 N N . ASN A 1 567 ? 55.028 -21.133 10.410 1.00 43.22 ? 623 ASN B N 1 ATOM 4268 C CA . ASN A 1 567 ? 54.201 -20.009 9.995 1.00 39.83 ? 623 ASN B CA 1 ATOM 4269 C C . ASN A 1 567 ? 52.711 -20.147 10.284 1.00 38.44 ? 623 ASN B C 1 ATOM 4270 O O . ASN A 1 567 ? 51.947 -19.214 10.049 1.00 44.22 ? 623 ASN B O 1 ATOM 4271 C CB . ASN A 1 567 ? 54.460 -19.665 8.530 1.00 39.91 ? 623 ASN B CB 1 ATOM 4272 C CG . ASN A 1 567 ? 55.616 -18.696 8.366 1.00 39.23 ? 623 ASN B CG 1 ATOM 4273 O OD1 . ASN A 1 567 ? 56.783 -19.082 8.454 1.00 38.59 ? 623 ASN B OD1 1 ATOM 4274 N ND2 . ASN A 1 567 ? 55.296 -17.425 8.147 1.00 39.14 ? 623 ASN B ND2 1 ATOM 4275 N N . LEU A 1 568 ? 52.310 -21.302 10.810 1.00 34.70 ? 624 LEU B N 1 ATOM 4276 C CA . LEU A 1 568 ? 50.911 -21.579 11.128 1.00 26.31 ? 624 LEU B CA 1 ATOM 4277 C C . LEU A 1 568 ? 50.380 -20.609 12.172 1.00 14.22 ? 624 LEU B C 1 ATOM 4278 O O . LEU A 1 568 ? 51.003 -20.419 13.208 1.00 26.42 ? 624 LEU B O 1 ATOM 4279 C CB . LEU A 1 568 ? 50.776 -23.013 11.638 1.00 25.20 ? 624 LEU B CB 1 ATOM 4280 C CG . LEU A 1 568 ? 49.352 -23.507 11.870 1.00 27.95 ? 624 LEU B CG 1 ATOM 4281 C CD1 . LEU A 1 568 ? 48.509 -23.248 10.632 1.00 13.26 ? 624 LEU B CD1 1 ATOM 4282 C CD2 . LEU A 1 568 ? 49.346 -24.989 12.239 1.00 14.43 ? 624 LEU B CD2 1 ATOM 4283 N N . GLY A 1 569 ? 49.267 -19.947 11.871 1.00 14.24 ? 625 GLY B N 1 ATOM 4284 C CA . GLY A 1 569 ? 48.616 -19.076 12.835 1.00 12.67 ? 625 GLY B CA 1 ATOM 4285 C C . GLY A 1 569 ? 47.350 -19.621 13.476 1.00 16.84 ? 625 GLY B C 1 ATOM 4286 O O . GLY A 1 569 ? 46.933 -19.161 14.541 1.00 12.87 ? 625 GLY B O 1 ATOM 4287 N N . VAL A 1 570 ? 46.729 -20.607 12.836 1.00 18.04 ? 626 VAL B N 1 ATOM 4288 C CA . VAL A 1 570 ? 45.550 -21.255 13.400 1.00 10.96 ? 626 VAL B CA 1 ATOM 4289 C C . VAL A 1 570 ? 45.564 -22.763 13.159 1.00 17.35 ? 626 VAL B C 1 ATOM 4290 O O . VAL A 1 570 ? 45.647 -23.229 12.022 1.00 14.44 ? 626 VAL B O 1 ATOM 4291 C CB . VAL A 1 570 ? 44.238 -20.689 12.828 1.00 17.09 ? 626 VAL B CB 1 ATOM 4292 C CG1 . VAL A 1 570 ? 43.057 -21.243 13.601 1.00 25.22 ? 626 VAL B CG1 1 ATOM 4293 C CG2 . VAL A 1 570 ? 44.221 -19.177 12.878 1.00 15.46 ? 626 VAL B CG2 1 ATOM 4294 N N . LEU A 1 571 ? 45.469 -23.530 14.230 1.00 11.54 ? 627 LEU B N 1 ATOM 4295 C CA . LEU A 1 571 ? 45.364 -24.971 14.106 1.00 14.00 ? 627 LEU B CA 1 ATOM 4296 C C . LEU A 1 571 ? 44.172 -25.431 14.931 1.00 14.87 ? 627 LEU B C 1 ATOM 4297 O O . LEU A 1 571 ? 44.020 -25.033 16.084 1.00 21.32 ? 627 LEU B O 1 ATOM 4298 C CB . LEU A 1 571 ? 46.655 -25.643 14.568 1.00 12.94 ? 627 LEU B CB 1 ATOM 4299 C CG . LEU A 1 571 ? 46.641 -27.166 14.630 1.00 15.79 ? 627 LEU B CG 1 ATOM 4300 C CD1 . LEU A 1 571 ? 46.409 -27.764 13.256 1.00 17.70 ? 627 LEU B CD1 1 ATOM 4301 C CD2 . LEU A 1 571 ? 47.930 -27.696 15.219 1.00 18.09 ? 627 LEU B CD2 1 ATOM 4302 N N . ASP A 1 572 ? 43.293 -26.221 14.329 1.00 10.92 ? 628 ASP B N 1 ATOM 4303 C CA . ASP A 1 572 ? 42.173 -26.786 15.068 1.00 15.30 ? 628 ASP B CA 1 ATOM 4304 C C . ASP A 1 572 ? 42.112 -28.294 14.834 1.00 15.96 ? 628 ASP B C 1 ATOM 4305 O O . ASP A 1 572 ? 41.772 -28.764 13.747 1.00 15.80 ? 628 ASP B O 1 ATOM 4306 C CB . ASP A 1 572 ? 40.871 -26.106 14.640 1.00 9.48 ? 628 ASP B CB 1 ATOM 4307 C CG . ASP A 1 572 ? 39.657 -26.663 15.339 1.00 26.90 ? 628 ASP B CG 1 ATOM 4308 O OD1 . ASP A 1 572 ? 39.807 -27.521 16.232 1.00 21.86 ? 628 ASP B OD1 1 ATOM 4309 O OD2 . ASP A 1 572 ? 38.541 -26.223 15.005 1.00 25.64 ? 628 ASP B OD2 1 ATOM 4310 N N . VAL A 1 573 ? 42.460 -29.044 15.870 1.00 21.29 ? 629 VAL B N 1 ATOM 4311 C CA . VAL A 1 573 ? 42.400 -30.501 15.847 1.00 25.14 ? 629 VAL B CA 1 ATOM 4312 C C . VAL A 1 573 ? 41.188 -31.092 16.589 1.00 19.10 ? 629 VAL B C 1 ATOM 4313 O O . VAL A 1 573 ? 41.072 -32.311 16.737 1.00 15.55 ? 629 VAL B O 1 ATOM 4314 C CB . VAL A 1 573 ? 43.724 -31.106 16.326 1.00 34.14 ? 629 VAL B CB 1 ATOM 4315 C CG1 . VAL A 1 573 ? 44.794 -30.885 15.267 1.00 13.49 ? 629 VAL B CG1 1 ATOM 4316 C CG2 . VAL A 1 573 ? 44.142 -30.476 17.650 1.00 34.37 ? 629 VAL B CG2 1 ATOM 4317 N N . SER A 1 574 ? 40.305 -30.213 17.061 1.00 14.15 ? 630 SER B N 1 ATOM 4318 C CA . SER A 1 574 ? 39.218 -30.577 17.969 1.00 16.31 ? 630 SER B CA 1 ATOM 4319 C C . SER A 1 574 ? 38.297 -31.678 17.464 1.00 22.01 ? 630 SER B C 1 ATOM 4320 O O . SER A 1 574 ? 38.138 -31.872 16.262 1.00 32.52 ? 630 SER B O 1 ATOM 4321 C CB . SER A 1 574 ? 38.370 -29.358 18.284 1.00 19.19 ? 630 SER B CB 1 ATOM 4322 O OG . SER A 1 574 ? 37.945 -28.752 17.084 1.00 26.65 ? 630 SER B OG 1 ATOM 4323 N N . HIS A 1 575 ? 37.711 -32.407 18.407 1.00 14.05 ? 631 HIS B N 1 ATOM 4324 C CA . HIS A 1 575 ? 36.798 -33.498 18.100 1.00 19.17 ? 631 HIS B CA 1 ATOM 4325 C C . HIS A 1 575 ? 37.471 -34.567 17.226 1.00 25.53 ? 631 HIS B C 1 ATOM 4326 O O . HIS A 1 575 ? 37.055 -34.829 16.085 1.00 10.94 ? 631 HIS B O 1 ATOM 4327 C CB . HIS A 1 575 ? 35.506 -32.968 17.467 1.00 9.65 ? 631 HIS B CB 1 ATOM 4328 C CG . HIS A 1 575 ? 34.702 -32.081 18.379 1.00 9.07 ? 631 HIS B CG 1 ATOM 4329 N ND1 . HIS A 1 575 ? 34.928 -30.728 18.478 1.00 8.66 ? 631 HIS B ND1 1 ATOM 4330 C CD2 . HIS A 1 575 ? 33.697 -32.366 19.231 1.00 8.91 ? 631 HIS B CD2 1 ATOM 4331 C CE1 . HIS A 1 575 ? 34.079 -30.207 19.354 1.00 12.14 ? 631 HIS B CE1 1 ATOM 4332 N NE2 . HIS A 1 575 ? 33.320 -31.183 19.826 1.00 8.39 ? 631 HIS B NE2 1 ATOM 4333 N N . ASN A 1 576 ? 38.513 -35.181 17.791 1.00 22.72 ? 632 ASN B N 1 ATOM 4334 C CA . ASN A 1 576 ? 39.173 -36.350 17.210 1.00 21.49 ? 632 ASN B CA 1 ATOM 4335 C C . ASN A 1 576 ? 39.502 -37.342 18.313 1.00 25.05 ? 632 ASN B C 1 ATOM 4336 O O . ASN A 1 576 ? 39.114 -37.143 19.452 1.00 35.85 ? 632 ASN B O 1 ATOM 4337 C CB . ASN A 1 576 ? 40.462 -35.975 16.468 1.00 21.04 ? 632 ASN B CB 1 ATOM 4338 C CG . ASN A 1 576 ? 40.209 -35.364 15.105 1.00 25.90 ? 632 ASN B CG 1 ATOM 4339 O OD1 . ASN A 1 576 ? 39.448 -35.889 14.302 1.00 12.37 ? 632 ASN B OD1 1 ATOM 4340 N ND2 . ASN A 1 576 ? 40.865 -34.249 14.838 1.00 28.56 ? 632 ASN B ND2 1 ATOM 4341 N N . GLN A 1 577 ? 40.177 -38.429 17.949 1.00 22.96 ? 633 GLN B N 1 ATOM 4342 C CA . GLN A 1 577 ? 40.668 -39.453 18.880 1.00 25.47 ? 633 GLN B CA 1 ATOM 4343 C C . GLN A 1 577 ? 42.164 -39.361 19.248 1.00 27.11 ? 633 GLN B C 1 ATOM 4344 O O . GLN A 1 577 ? 42.760 -40.326 19.747 1.00 27.48 ? 633 GLN B O 1 ATOM 4345 C CB . GLN A 1 577 ? 40.267 -40.845 18.412 1.00 27.02 ? 633 GLN B CB 1 ATOM 4346 C CG . GLN A 1 577 ? 38.794 -41.105 18.591 1.00 20.67 ? 633 GLN B CG 1 ATOM 4347 C CD . GLN A 1 577 ? 38.280 -42.184 17.671 1.00 17.91 ? 633 GLN B CD 1 ATOM 4348 O OE1 . GLN A 1 577 ? 37.236 -42.026 17.035 1.00 19.87 ? 633 GLN B OE1 1 ATOM 4349 N NE2 . GLN A 1 577 ? 39.009 -43.291 17.591 1.00 17.24 ? 633 GLN B NE2 1 ATOM 4350 N N . LEU A 1 578 ? 42.782 -38.243 18.890 1.00 20.44 ? 634 LEU B N 1 ATOM 4351 C CA . LEU A 1 578 ? 44.204 -38.017 19.125 1.00 24.27 ? 634 LEU B CA 1 ATOM 4352 C C . LEU A 1 578 ? 44.634 -38.189 20.583 1.00 29.59 ? 634 LEU B C 1 ATOM 4353 O O . LEU A 1 578 ? 43.884 -37.860 21.495 1.00 34.98 ? 634 LEU B O 1 ATOM 4354 C CB . LEU A 1 578 ? 44.565 -36.609 18.666 1.00 21.74 ? 634 LEU B CB 1 ATOM 4355 C CG . LEU A 1 578 ? 44.286 -36.321 17.199 1.00 19.10 ? 634 LEU B CG 1 ATOM 4356 C CD1 . LEU A 1 578 ? 44.590 -34.873 16.892 1.00 20.94 ? 634 LEU B CD1 1 ATOM 4357 C CD2 . LEU A 1 578 ? 45.124 -37.250 16.346 1.00 16.26 ? 634 LEU B CD2 1 ATOM 4358 N N . THR A 1 579 ? 45.852 -38.699 20.782 1.00 17.78 ? 635 THR B N 1 ATOM 4359 C CA . THR A 1 579 ? 46.427 -38.936 22.110 1.00 35.54 ? 635 THR B CA 1 ATOM 4360 C C . THR A 1 579 ? 47.852 -38.403 22.194 1.00 36.24 ? 635 THR B C 1 ATOM 4361 O O . THR A 1 579 ? 48.375 -37.848 21.227 1.00 18.97 ? 635 THR B O 1 ATOM 4362 C CB . THR A 1 579 ? 46.489 -40.438 22.470 1.00 19.10 ? 635 THR B CB 1 ATOM 4363 O OG1 . THR A 1 579 ? 47.208 -41.148 21.453 1.00 24.18 ? 635 THR B OG1 1 ATOM 4364 C CG2 . THR A 1 579 ? 45.099 -41.030 22.617 1.00 18.60 ? 635 THR B CG2 1 ATOM 4365 N N . GLY A 1 580 ? 48.481 -38.586 23.355 1.00 19.60 ? 636 GLY B N 1 ATOM 4366 C CA . GLY A 1 580 ? 49.834 -38.107 23.577 1.00 40.46 ? 636 GLY B CA 1 ATOM 4367 C C . GLY A 1 580 ? 49.855 -36.668 24.056 1.00 37.94 ? 636 GLY B C 1 ATOM 4368 O O . GLY A 1 580 ? 48.805 -36.093 24.313 1.00 36.20 ? 636 GLY B O 1 ATOM 4369 N N . ASN A 1 581 ? 51.041 -36.075 24.170 1.00 38.47 ? 637 ASN B N 1 ATOM 4370 C CA . ASN A 1 581 ? 51.129 -34.708 24.660 1.00 20.00 ? 637 ASN B CA 1 ATOM 4371 C C . ASN A 1 581 ? 51.172 -33.661 23.561 1.00 19.52 ? 637 ASN B C 1 ATOM 4372 O O . ASN A 1 581 ? 51.135 -33.983 22.390 1.00 22.57 ? 637 ASN B O 1 ATOM 4373 C CB . ASN A 1 581 ? 52.301 -34.548 25.633 1.00 20.87 ? 637 ASN B CB 1 ATOM 4374 C CG . ASN A 1 581 ? 53.653 -34.605 24.958 1.00 21.71 ? 637 ASN B CG 1 ATOM 4375 O OD1 . ASN A 1 581 ? 53.871 -34.014 23.902 1.00 38.25 ? 637 ASN B OD1 1 ATOM 4376 N ND2 . ASN A 1 581 ? 54.590 -35.290 25.593 1.00 22.67 ? 637 ASN B ND2 1 ATOM 4377 N N . LEU A 1 582 ? 51.213 -32.398 23.950 1.00 21.44 ? 638 LEU B N 1 ATOM 4378 C CA . LEU A 1 582 ? 51.308 -31.294 23.000 1.00 23.49 ? 638 LEU B CA 1 ATOM 4379 C C . LEU A 1 582 ? 52.704 -30.680 22.836 1.00 30.12 ? 638 LEU B C 1 ATOM 4380 O O . LEU A 1 582 ? 52.848 -29.667 22.154 1.00 30.18 ? 638 LEU B O 1 ATOM 4381 C CB . LEU A 1 582 ? 50.233 -30.243 23.284 1.00 17.78 ? 638 LEU B CB 1 ATOM 4382 C CG . LEU A 1 582 ? 48.881 -30.964 23.380 1.00 20.54 ? 638 LEU B CG 1 ATOM 4383 C CD1 . LEU A 1 582 ? 47.749 -30.081 23.888 1.00 17.10 ? 638 LEU B CD1 1 ATOM 4384 C CD2 . LEU A 1 582 ? 48.517 -31.597 22.051 1.00 20.94 ? 638 LEU B CD2 1 ATOM 4385 N N . ASN A 1 583 ? 53.715 -31.273 23.473 1.00 33.57 ? 639 ASN B N 1 ATOM 4386 C CA . ASN A 1 583 ? 55.062 -30.689 23.508 1.00 31.09 ? 639 ASN B CA 1 ATOM 4387 C C . ASN A 1 583 ? 55.572 -30.246 22.137 1.00 30.67 ? 639 ASN B C 1 ATOM 4388 O O . ASN A 1 583 ? 56.275 -29.246 22.008 1.00 21.68 ? 639 ASN B O 1 ATOM 4389 C CB . ASN A 1 583 ? 56.075 -31.666 24.112 1.00 29.32 ? 639 ASN B CB 1 ATOM 4390 C CG . ASN A 1 583 ? 55.680 -32.163 25.494 1.00 33.06 ? 639 ASN B CG 1 ATOM 4391 O OD1 . ASN A 1 583 ? 56.097 -33.245 25.900 1.00 23.16 ? 639 ASN B OD1 1 ATOM 4392 N ND2 . ASN A 1 583 ? 54.874 -31.385 26.218 1.00 21.78 ? 639 ASN B ND2 1 ATOM 4393 N N . VAL A 1 584 ? 55.194 -30.997 21.112 1.00 29.57 ? 640 VAL B N 1 ATOM 4394 C CA . VAL A 1 584 ? 55.578 -30.693 19.742 1.00 31.08 ? 640 VAL B CA 1 ATOM 4395 C C . VAL A 1 584 ? 54.974 -29.356 19.250 1.00 35.33 ? 640 VAL B C 1 ATOM 4396 O O . VAL A 1 584 ? 55.417 -28.789 18.247 1.00 37.28 ? 640 VAL B O 1 ATOM 4397 C CB . VAL A 1 584 ? 55.200 -31.875 18.826 1.00 23.79 ? 640 VAL B CB 1 ATOM 4398 C CG1 . VAL A 1 584 ? 53.732 -32.186 18.967 1.00 27.81 ? 640 VAL B CG1 1 ATOM 4399 C CG2 . VAL A 1 584 ? 55.569 -31.607 17.384 1.00 23.43 ? 640 VAL B CG2 1 ATOM 4400 N N . LEU A 1 585 ? 53.985 -28.844 19.983 1.00 33.56 ? 641 LEU B N 1 ATOM 4401 C CA . LEU A 1 585 ? 53.352 -27.561 19.656 1.00 34.82 ? 641 LEU B CA 1 ATOM 4402 C C . LEU A 1 585 ? 53.883 -26.363 20.434 1.00 41.05 ? 641 LEU B C 1 ATOM 4403 O O . LEU A 1 585 ? 53.407 -25.239 20.233 1.00 42.52 ? 641 LEU B O 1 ATOM 4404 C CB . LEU A 1 585 ? 51.842 -27.636 19.880 1.00 26.57 ? 641 LEU B CB 1 ATOM 4405 C CG . LEU A 1 585 ? 50.943 -28.056 18.721 1.00 26.31 ? 641 LEU B CG 1 ATOM 4406 C CD1 . LEU A 1 585 ? 51.713 -28.824 17.652 1.00 31.35 ? 641 LEU B CD1 1 ATOM 4407 C CD2 . LEU A 1 585 ? 49.808 -28.884 19.279 1.00 21.67 ? 641 LEU B CD2 1 ATOM 4408 N N . THR A 1 586 ? 54.836 -26.596 21.336 1.00 42.05 ? 642 THR B N 1 ATOM 4409 C CA . THR A 1 586 ? 55.225 -25.556 22.296 1.00 41.98 ? 642 THR B CA 1 ATOM 4410 C C . THR A 1 586 ? 56.292 -24.603 21.769 1.00 42.48 ? 642 THR B C 1 ATOM 4411 O O . THR A 1 586 ? 56.590 -23.595 22.401 1.00 47.60 ? 642 THR B O 1 ATOM 4412 C CB . THR A 1 586 ? 55.624 -26.126 23.695 1.00 21.40 ? 642 THR B CB 1 ATOM 4413 O OG1 . THR A 1 586 ? 56.813 -26.921 23.587 1.00 21.78 ? 642 THR B OG1 1 ATOM 4414 C CG2 . THR A 1 586 ? 54.498 -26.965 24.274 1.00 20.11 ? 642 THR B CG2 1 ATOM 4415 N N . ASP A 1 587 ? 56.870 -24.921 20.619 1.00 48.59 ? 643 ASP B N 1 ATOM 4416 C CA . ASP A 1 587 ? 57.806 -24.000 19.989 1.00 56.00 ? 643 ASP B CA 1 ATOM 4417 C C . ASP A 1 587 ? 57.211 -23.133 18.875 1.00 48.85 ? 643 ASP B C 1 ATOM 4418 O O . ASP A 1 587 ? 57.936 -22.369 18.239 1.00 42.30 ? 643 ASP B O 1 ATOM 4419 C CB . ASP A 1 587 ? 59.057 -24.728 19.498 1.00 64.94 ? 643 ASP B CB 1 ATOM 4420 C CG . ASP A 1 587 ? 60.328 -23.960 19.809 1.00 64.05 ? 643 ASP B CG 1 ATOM 4421 O OD1 . ASP A 1 587 ? 60.269 -23.059 20.679 1.00 54.62 ? 643 ASP B OD1 1 ATOM 4422 O OD2 . ASP A 1 587 ? 61.378 -24.258 19.193 1.00 67.19 ? 643 ASP B OD2 1 ATOM 4423 N N . LEU A 1 588 ? 55.904 -23.217 18.642 1.00 46.19 ? 644 LEU B N 1 ATOM 4424 C CA . LEU A 1 588 ? 55.368 -22.522 17.488 1.00 19.04 ? 644 LEU B CA 1 ATOM 4425 C C . LEU A 1 588 ? 54.972 -21.129 17.922 1.00 18.55 ? 644 LEU B C 1 ATOM 4426 O O . LEU A 1 588 ? 53.867 -20.906 18.399 1.00 42.11 ? 644 LEU B O 1 ATOM 4427 C CB . LEU A 1 588 ? 54.136 -23.273 16.972 1.00 18.12 ? 644 LEU B CB 1 ATOM 4428 C CG . LEU A 1 588 ? 54.363 -24.723 16.546 1.00 26.42 ? 644 LEU B CG 1 ATOM 4429 C CD1 . LEU A 1 588 ? 53.083 -25.386 16.123 1.00 17.66 ? 644 LEU B CD1 1 ATOM 4430 C CD2 . LEU A 1 588 ? 55.350 -24.773 15.418 1.00 19.24 ? 644 LEU B CD2 1 ATOM 4431 N N . GLN A 1 589 ? 55.830 -20.165 17.618 1.00 58.86 ? 645 GLN B N 1 ATOM 4432 C CA . GLN A 1 589 ? 55.711 -18.832 18.205 1.00 56.38 ? 645 GLN B CA 1 ATOM 4433 C C . GLN A 1 589 ? 54.636 -18.009 17.509 1.00 48.07 ? 645 GLN B C 1 ATOM 4434 O O . GLN A 1 589 ? 54.047 -17.104 18.101 1.00 44.10 ? 645 GLN B O 1 ATOM 4435 C CB . GLN A 1 589 ? 57.063 -18.103 18.179 1.00 60.74 ? 645 GLN B CB 1 ATOM 4436 C CG . GLN A 1 589 ? 57.473 -17.542 16.816 1.00 64.83 ? 645 GLN B CG 1 ATOM 4437 C CD . GLN A 1 589 ? 57.683 -18.618 15.764 1.00 67.84 ? 645 GLN B CD 1 ATOM 4438 O OE1 . GLN A 1 589 ? 56.722 -19.141 15.192 1.00 65.20 ? 645 GLN B OE1 1 ATOM 4439 N NE2 . GLN A 1 589 ? 58.944 -18.952 15.502 1.00 68.73 ? 645 GLN B NE2 1 ATOM 4440 N N . ASN A 1 590 ? 54.380 -18.328 16.247 1.00 42.30 ? 646 ASN B N 1 ATOM 4441 C CA . ASN A 1 590 ? 53.380 -17.586 15.501 1.00 31.96 ? 646 ASN B CA 1 ATOM 4442 C C . ASN A 1 590 ? 51.996 -18.161 15.691 1.00 24.99 ? 646 ASN B C 1 ATOM 4443 O O . ASN A 1 590 ? 51.017 -17.638 15.150 1.00 22.12 ? 646 ASN B O 1 ATOM 4444 C CB . ASN A 1 590 ? 53.748 -17.503 14.022 1.00 30.62 ? 646 ASN B CB 1 ATOM 4445 C CG . ASN A 1 590 ? 54.808 -16.457 13.758 1.00 33.81 ? 646 ASN B CG 1 ATOM 4446 O OD1 . ASN A 1 590 ? 54.497 -15.288 13.515 1.00 35.99 ? 646 ASN B OD1 1 ATOM 4447 N ND2 . ASN A 1 590 ? 56.070 -16.864 13.832 1.00 33.35 ? 646 ASN B ND2 1 ATOM 4448 N N . LEU A 1 591 ? 51.916 -19.234 16.471 1.00 25.37 ? 647 LEU B N 1 ATOM 4449 C CA . LEU A 1 591 ? 50.631 -19.843 16.732 1.00 20.75 ? 647 LEU B CA 1 ATOM 4450 C C . LEU A 1 591 ? 49.763 -18.848 17.478 1.00 28.17 ? 647 LEU B C 1 ATOM 4451 O O . LEU A 1 591 ? 50.136 -18.320 18.528 1.00 36.05 ? 647 LEU B O 1 ATOM 4452 C CB . LEU A 1 591 ? 50.781 -21.139 17.517 1.00 21.85 ? 647 LEU B CB 1 ATOM 4453 C CG . LEU A 1 591 ? 49.530 -22.012 17.446 1.00 22.96 ? 647 LEU B CG 1 ATOM 4454 C CD1 . LEU A 1 591 ? 49.058 -22.152 15.992 1.00 21.49 ? 647 LEU B CD1 1 ATOM 4455 C CD2 . LEU A 1 591 ? 49.781 -23.373 18.070 1.00 20.92 ? 647 LEU B CD2 1 ATOM 4456 N N . VAL A 1 592 ? 48.597 -18.598 16.904 1.00 29.39 ? 648 VAL B N 1 ATOM 4457 C CA . VAL A 1 592 ? 47.669 -17.574 17.365 1.00 21.77 ? 648 VAL B CA 1 ATOM 4458 C C . VAL A 1 592 ? 46.446 -18.233 18.005 1.00 18.62 ? 648 VAL B C 1 ATOM 4459 O O . VAL A 1 592 ? 46.074 -17.888 19.113 1.00 11.50 ? 648 VAL B O 1 ATOM 4460 C CB . VAL A 1 592 ? 47.288 -16.600 16.220 1.00 26.15 ? 648 VAL B CB 1 ATOM 4461 C CG1 . VAL A 1 592 ? 46.149 -15.691 16.624 1.00 20.28 ? 648 VAL B CG1 1 ATOM 4462 C CG2 . VAL A 1 592 ? 48.499 -15.789 15.815 1.00 31.70 ? 648 VAL B CG2 1 ATOM 4463 N N . SER A 1 593 ? 45.772 -19.104 17.254 1.00 21.05 ? 649 SER B N 1 ATOM 4464 C CA . SER A 1 593 ? 44.606 -19.829 17.748 1.00 10.61 ? 649 SER B CA 1 ATOM 4465 C C . SER A 1 593 ? 44.822 -21.343 17.706 1.00 11.05 ? 649 SER B C 1 ATOM 4466 O O . SER A 1 593 ? 45.253 -21.876 16.691 1.00 35.08 ? 649 SER B O 1 ATOM 4467 C CB . SER A 1 593 ? 43.373 -19.452 16.931 1.00 23.62 ? 649 SER B CB 1 ATOM 4468 O OG . SER A 1 593 ? 42.209 -20.074 17.442 1.00 28.57 ? 649 SER B OG 1 ATOM 4469 N N . LEU A 1 594 ? 44.537 -22.027 18.816 1.00 17.25 ? 650 LEU B N 1 ATOM 4470 C CA . LEU A 1 594 ? 44.725 -23.476 18.912 1.00 11.68 ? 650 LEU B CA 1 ATOM 4471 C C . LEU A 1 594 ? 43.559 -24.146 19.606 1.00 11.23 ? 650 LEU B C 1 ATOM 4472 O O . LEU A 1 594 ? 43.330 -23.908 20.793 1.00 41.94 ? 650 LEU B O 1 ATOM 4473 C CB . LEU A 1 594 ? 46.006 -23.797 19.692 1.00 14.76 ? 650 LEU B CB 1 ATOM 4474 C CG . LEU A 1 594 ? 46.209 -25.261 20.080 1.00 13.26 ? 650 LEU B CG 1 ATOM 4475 C CD1 . LEU A 1 594 ? 46.303 -26.111 18.816 1.00 49.10 ? 650 LEU B CD1 1 ATOM 4476 C CD2 . LEU A 1 594 ? 47.443 -25.445 20.945 1.00 14.25 ? 650 LEU B CD2 1 ATOM 4477 N N . ASN A 1 595 ? 42.839 -25.014 18.900 1.00 10.91 ? 651 ASN B N 1 ATOM 4478 C CA . ASN A 1 595 ? 41.731 -25.719 19.534 1.00 10.57 ? 651 ASN B CA 1 ATOM 4479 C C . ASN A 1 595 ? 42.061 -27.198 19.592 1.00 11.22 ? 651 ASN B C 1 ATOM 4480 O O . ASN A 1 595 ? 41.961 -27.902 18.595 1.00 25.90 ? 651 ASN B O 1 ATOM 4481 C CB . ASN A 1 595 ? 40.442 -25.443 18.756 1.00 9.64 ? 651 ASN B CB 1 ATOM 4482 C CG . ASN A 1 595 ? 39.205 -26.006 19.420 1.00 9.25 ? 651 ASN B CG 1 ATOM 4483 O OD1 . ASN A 1 595 ? 39.264 -27.040 20.063 1.00 9.73 ? 651 ASN B OD1 1 ATOM 4484 N ND2 . ASN A 1 595 ? 38.062 -25.331 19.262 1.00 16.27 ? 651 ASN B ND2 1 ATOM 4485 N N . ILE A 1 596 ? 42.466 -27.652 20.778 1.00 32.94 ? 652 ILE B N 1 ATOM 4486 C CA . ILE A 1 596 ? 42.802 -29.058 21.026 1.00 12.47 ? 652 ILE B CA 1 ATOM 4487 C C . ILE A 1 596 ? 41.692 -29.830 21.729 1.00 16.41 ? 652 ILE B C 1 ATOM 4488 O O . ILE A 1 596 ? 41.871 -30.997 22.089 1.00 12.79 ? 652 ILE B O 1 ATOM 4489 C CB . ILE A 1 596 ? 44.145 -29.255 21.793 1.00 13.43 ? 652 ILE B CB 1 ATOM 4490 C CG1 . ILE A 1 596 ? 44.280 -28.278 22.960 1.00 13.41 ? 652 ILE B CG1 1 ATOM 4491 C CG2 . ILE A 1 596 ? 45.314 -29.087 20.865 1.00 13.93 ? 652 ILE B CG2 1 ATOM 4492 C CD1 . ILE A 1 596 ? 43.627 -28.745 24.233 1.00 13.41 ? 652 ILE B CD1 1 ATOM 4493 N N . SER A 1 597 ? 40.564 -29.160 21.938 1.00 15.28 ? 653 SER B N 1 ATOM 4494 C CA . SER A 1 597 ? 39.492 -29.658 22.781 1.00 11.22 ? 653 SER B CA 1 ATOM 4495 C C . SER A 1 597 ? 38.897 -30.955 22.248 1.00 33.48 ? 653 SER B C 1 ATOM 4496 O O . SER A 1 597 ? 39.048 -31.277 21.070 1.00 11.26 ? 653 SER B O 1 ATOM 4497 C CB . SER A 1 597 ? 38.395 -28.617 22.856 1.00 10.34 ? 653 SER B CB 1 ATOM 4498 O OG . SER A 1 597 ? 37.601 -28.691 21.689 1.00 15.04 ? 653 SER B OG 1 ATOM 4499 N N . TYR A 1 598 ? 38.242 -31.699 23.136 1.00 32.93 ? 654 TYR B N 1 ATOM 4500 C CA . TYR A 1 598 ? 37.597 -32.967 22.794 1.00 11.52 ? 654 TYR B CA 1 ATOM 4501 C C . TYR A 1 598 ? 38.525 -33.915 22.048 1.00 21.80 ? 654 TYR B C 1 ATOM 4502 O O . TYR A 1 598 ? 38.308 -34.227 20.876 1.00 23.51 ? 654 TYR B O 1 ATOM 4503 C CB . TYR A 1 598 ? 36.303 -32.734 22.009 1.00 18.37 ? 654 TYR B CB 1 ATOM 4504 C CG . TYR A 1 598 ? 35.231 -32.079 22.841 1.00 15.54 ? 654 TYR B CG 1 ATOM 4505 C CD1 . TYR A 1 598 ? 34.391 -32.835 23.663 1.00 15.95 ? 654 TYR B CD1 1 ATOM 4506 C CD2 . TYR A 1 598 ? 35.076 -30.702 22.835 1.00 20.39 ? 654 TYR B CD2 1 ATOM 4507 C CE1 . TYR A 1 598 ? 33.420 -32.233 24.443 1.00 9.80 ? 654 TYR B CE1 1 ATOM 4508 C CE2 . TYR A 1 598 ? 34.107 -30.090 23.614 1.00 27.15 ? 654 TYR B CE2 1 ATOM 4509 C CZ . TYR A 1 598 ? 33.281 -30.858 24.410 1.00 28.92 ? 654 TYR B CZ 1 ATOM 4510 O OH . TYR A 1 598 ? 32.319 -30.231 25.166 1.00 26.97 ? 654 TYR B OH 1 ATOM 4511 N N . ASN A 1 599 ? 39.567 -34.350 22.749 1.00 23.19 ? 655 ASN B N 1 ATOM 4512 C CA . ASN A 1 599 ? 40.504 -35.353 22.269 1.00 20.14 ? 655 ASN B CA 1 ATOM 4513 C C . ASN A 1 599 ? 40.987 -36.170 23.464 1.00 22.16 ? 655 ASN B C 1 ATOM 4514 O O . ASN A 1 599 ? 40.495 -35.996 24.573 1.00 19.01 ? 655 ASN B O 1 ATOM 4515 C CB . ASN A 1 599 ? 41.688 -34.695 21.562 1.00 24.85 ? 655 ASN B CB 1 ATOM 4516 C CG . ASN A 1 599 ? 41.448 -34.491 20.076 1.00 14.16 ? 655 ASN B CG 1 ATOM 4517 O OD1 . ASN A 1 599 ? 41.407 -35.450 19.320 1.00 13.81 ? 655 ASN B OD1 1 ATOM 4518 N ND2 . ASN A 1 599 ? 41.320 -33.238 19.652 1.00 12.93 ? 655 ASN B ND2 1 ATOM 4519 N N . ASP A 1 600 ? 41.905 -37.099 23.231 1.00 28.09 ? 656 ASP B N 1 ATOM 4520 C CA . ASP A 1 600 ? 42.458 -37.930 24.303 1.00 25.37 ? 656 ASP B CA 1 ATOM 4521 C C . ASP A 1 600 ? 43.818 -37.515 24.867 1.00 23.82 ? 656 ASP B C 1 ATOM 4522 O O . ASP A 1 600 ? 44.477 -38.307 25.530 1.00 33.24 ? 656 ASP B O 1 ATOM 4523 C CB . ASP A 1 600 ? 42.347 -39.426 23.994 1.00 30.42 ? 656 ASP B CB 1 ATOM 4524 C CG . ASP A 1 600 ? 40.911 -39.942 24.128 1.00 29.94 ? 656 ASP B CG 1 ATOM 4525 O OD1 . ASP A 1 600 ? 40.372 -39.893 25.256 1.00 27.37 ? 656 ASP B OD1 1 ATOM 4526 O OD2 . ASP A 1 600 ? 40.330 -40.394 23.111 1.00 24.21 ? 656 ASP B OD2 1 ATOM 4527 N N . PHE A 1 601 ? 44.261 -36.309 24.532 1.00 16.47 ? 657 PHE B N 1 ATOM 4528 C CA . PHE A 1 601 ? 45.538 -35.772 25.010 1.00 17.05 ? 657 PHE B CA 1 ATOM 4529 C C . PHE A 1 601 ? 45.736 -35.765 26.542 1.00 17.43 ? 657 PHE B C 1 ATOM 4530 O O . PHE A 1 601 ? 44.786 -35.637 27.311 1.00 17.00 ? 657 PHE B O 1 ATOM 4531 C CB . PHE A 1 601 ? 45.734 -34.341 24.506 1.00 35.86 ? 657 PHE B CB 1 ATOM 4532 C CG . PHE A 1 601 ? 45.766 -34.211 23.018 1.00 16.28 ? 657 PHE B CG 1 ATOM 4533 C CD1 . PHE A 1 601 ? 46.784 -34.784 22.279 1.00 48.48 ? 657 PHE B CD1 1 ATOM 4534 C CD2 . PHE A 1 601 ? 44.804 -33.477 22.355 1.00 22.84 ? 657 PHE B CD2 1 ATOM 4535 C CE1 . PHE A 1 601 ? 46.824 -34.652 20.913 1.00 16.76 ? 657 PHE B CE1 1 ATOM 4536 C CE2 . PHE A 1 601 ? 44.844 -33.344 20.978 1.00 23.24 ? 657 PHE B CE2 1 ATOM 4537 C CZ . PHE A 1 601 ? 45.856 -33.929 20.263 1.00 15.83 ? 657 PHE B CZ 1 ATOM 4538 N N . SER A 1 602 ? 46.995 -35.908 26.953 1.00 18.27 ? 658 SER B N 1 ATOM 4539 C CA . SER A 1 602 ? 47.403 -35.905 28.356 1.00 35.59 ? 658 SER B CA 1 ATOM 4540 C C . SER A 1 602 ? 48.843 -35.408 28.505 1.00 34.29 ? 658 SER B C 1 ATOM 4541 O O . SER A 1 602 ? 49.621 -35.448 27.559 1.00 19.77 ? 658 SER B O 1 ATOM 4542 C CB . SER A 1 602 ? 47.240 -37.294 28.994 1.00 19.30 ? 658 SER B CB 1 ATOM 4543 O OG . SER A 1 602 ? 47.970 -38.287 28.314 1.00 51.41 ? 658 SER B OG 1 ATOM 4544 N N . GLY A 1 603 ? 49.200 -34.970 29.710 1.00 31.70 ? 659 GLY B N 1 ATOM 4545 C CA . GLY A 1 603 ? 50.503 -34.377 29.952 1.00 20.40 ? 659 GLY B CA 1 ATOM 4546 C C . GLY A 1 603 ? 50.421 -32.892 30.210 1.00 19.93 ? 659 GLY B C 1 ATOM 4547 O O . GLY A 1 603 ? 49.359 -32.303 30.085 1.00 19.07 ? 659 GLY B O 1 ATOM 4548 N N . ASP A 1 604 ? 51.544 -32.285 30.570 1.00 20.54 ? 660 ASP B N 1 ATOM 4549 C CA . ASP A 1 604 ? 51.541 -30.902 31.039 1.00 33.94 ? 660 ASP B CA 1 ATOM 4550 C C . ASP A 1 604 ? 51.831 -29.872 29.953 1.00 34.48 ? 660 ASP B C 1 ATOM 4551 O O . ASP A 1 604 ? 52.587 -30.133 29.020 1.00 42.45 ? 660 ASP B O 1 ATOM 4552 C CB . ASP A 1 604 ? 52.509 -30.714 32.216 1.00 21.09 ? 660 ASP B CB 1 ATOM 4553 C CG . ASP A 1 604 ? 53.930 -31.119 31.875 1.00 31.15 ? 660 ASP B CG 1 ATOM 4554 O OD1 . ASP A 1 604 ? 54.113 -31.990 30.998 1.00 32.09 ? 660 ASP B OD1 1 ATOM 4555 O OD2 . ASP A 1 604 ? 54.867 -30.563 32.485 1.00 31.99 ? 660 ASP B OD2 1 ATOM 4556 N N . LEU A 1 605 ? 51.229 -28.694 30.095 1.00 32.40 ? 661 LEU B N 1 ATOM 4557 C CA . LEU A 1 605 ? 51.527 -27.573 29.220 1.00 31.80 ? 661 LEU B CA 1 ATOM 4558 C C . LEU A 1 605 ? 52.227 -26.496 30.041 1.00 38.10 ? 661 LEU B C 1 ATOM 4559 O O . LEU A 1 605 ? 51.909 -26.302 31.210 1.00 40.85 ? 661 LEU B O 1 ATOM 4560 C CB . LEU A 1 605 ? 50.227 -26.996 28.669 1.00 26.08 ? 661 LEU B CB 1 ATOM 4561 C CG . LEU A 1 605 ? 49.325 -27.957 27.897 1.00 28.61 ? 661 LEU B CG 1 ATOM 4562 C CD1 . LEU A 1 605 ? 47.919 -27.386 27.785 1.00 23.80 ? 661 LEU B CD1 1 ATOM 4563 C CD2 . LEU A 1 605 ? 49.917 -28.267 26.521 1.00 17.57 ? 661 LEU B CD2 1 ATOM 4564 N N . PRO A 1 606 ? 53.179 -25.778 29.425 1.00 35.91 ? 662 PRO B N 1 ATOM 4565 C CA . PRO A 1 606 ? 53.886 -24.693 30.111 1.00 28.31 ? 662 PRO B CA 1 ATOM 4566 C C . PRO A 1 606 ? 52.940 -23.578 30.531 1.00 32.26 ? 662 PRO B C 1 ATOM 4567 O O . PRO A 1 606 ? 51.803 -23.527 30.073 1.00 34.11 ? 662 PRO B O 1 ATOM 4568 C CB . PRO A 1 606 ? 54.879 -24.193 29.057 1.00 31.54 ? 662 PRO B CB 1 ATOM 4569 C CG . PRO A 1 606 ? 54.327 -24.664 27.750 1.00 34.55 ? 662 PRO B CG 1 ATOM 4570 C CD . PRO A 1 606 ? 53.689 -25.984 28.059 1.00 35.35 ? 662 PRO B CD 1 ATOM 4571 N N . ASN A 1 607 ? 53.418 -22.708 31.416 1.00 35.39 ? 663 ASN B N 1 ATOM 4572 C CA . ASN A 1 607 ? 52.649 -21.601 31.983 1.00 25.78 ? 663 ASN B CA 1 ATOM 4573 C C . ASN A 1 607 ? 52.750 -20.340 31.118 1.00 33.49 ? 663 ASN B C 1 ATOM 4574 O O . ASN A 1 607 ? 52.491 -19.239 31.587 1.00 41.73 ? 663 ASN B O 1 ATOM 4575 C CB . ASN A 1 607 ? 53.060 -21.330 33.428 1.00 26.13 ? 663 ASN B CB 1 ATOM 4576 C CG . ASN A 1 607 ? 51.970 -20.633 34.247 1.00 26.31 ? 663 ASN B CG 1 ATOM 4577 O OD1 . ASN A 1 607 ? 51.076 -19.980 33.710 1.00 18.53 ? 663 ASN B OD1 1 ATOM 4578 N ND2 . ASN A 1 607 ? 52.069 -20.752 35.571 1.00 30.36 ? 663 ASN B ND2 1 ATOM 4579 N N . THR A 1 608 ? 53.219 -20.494 29.881 1.00 35.03 ? 664 THR B N 1 ATOM 4580 C CA . THR A 1 608 ? 53.292 -19.383 28.934 1.00 28.01 ? 664 THR B CA 1 ATOM 4581 C C . THR A 1 608 ? 51.925 -18.701 28.827 1.00 36.35 ? 664 THR B C 1 ATOM 4582 O O . THR A 1 608 ? 50.896 -19.302 29.159 1.00 30.50 ? 664 THR B O 1 ATOM 4583 C CB . THR A 1 608 ? 53.709 -19.865 27.531 1.00 36.95 ? 664 THR B CB 1 ATOM 4584 O OG1 . THR A 1 608 ? 52.566 -20.403 26.853 1.00 45.34 ? 664 THR B OG1 1 ATOM 4585 C CG2 . THR A 1 608 ? 54.815 -20.913 27.605 1.00 19.95 ? 664 THR B CG2 1 ATOM 4586 N N . PRO A 1 609 ? 51.908 -17.417 28.410 1.00 50.62 ? 665 PRO B N 1 ATOM 4587 C CA . PRO A 1 609 ? 50.634 -16.685 28.323 1.00 46.11 ? 665 PRO B CA 1 ATOM 4588 C C . PRO A 1 609 ? 49.729 -17.278 27.254 1.00 40.32 ? 665 PRO B C 1 ATOM 4589 O O . PRO A 1 609 ? 48.510 -17.068 27.269 1.00 37.13 ? 665 PRO B O 1 ATOM 4590 C CB . PRO A 1 609 ? 51.063 -15.269 27.924 1.00 41.16 ? 665 PRO B CB 1 ATOM 4591 C CG . PRO A 1 609 ? 52.510 -15.179 28.311 1.00 44.94 ? 665 PRO B CG 1 ATOM 4592 C CD . PRO A 1 609 ? 53.058 -16.554 28.087 1.00 49.53 ? 665 PRO B CD 1 ATOM 4593 N N . PHE A 1 610 ? 50.325 -18.012 26.324 1.00 33.15 ? 666 PHE B N 1 ATOM 4594 C CA . PHE A 1 610 ? 49.525 -18.742 25.363 1.00 37.11 ? 666 PHE B CA 1 ATOM 4595 C C . PHE A 1 610 ? 48.566 -19.718 26.050 1.00 44.38 ? 666 PHE B C 1 ATOM 4596 O O . PHE A 1 610 ? 47.351 -19.559 25.970 1.00 41.31 ? 666 PHE B O 1 ATOM 4597 C CB . PHE A 1 610 ? 50.407 -19.493 24.377 1.00 36.25 ? 666 PHE B CB 1 ATOM 4598 C CG . PHE A 1 610 ? 49.683 -19.921 23.135 1.00 43.60 ? 666 PHE B CG 1 ATOM 4599 C CD1 . PHE A 1 610 ? 48.313 -19.767 23.022 1.00 47.50 ? 666 PHE B CD1 1 ATOM 4600 C CD2 . PHE A 1 610 ? 50.374 -20.460 22.070 1.00 58.01 ? 666 PHE B CD2 1 ATOM 4601 C CE1 . PHE A 1 610 ? 47.642 -20.157 21.887 1.00 56.86 ? 666 PHE B CE1 1 ATOM 4602 C CE2 . PHE A 1 610 ? 49.707 -20.853 20.918 1.00 64.52 ? 666 PHE B CE2 1 ATOM 4603 C CZ . PHE A 1 610 ? 48.338 -20.702 20.829 1.00 62.44 ? 666 PHE B CZ 1 ATOM 4604 N N . PHE A 1 611 ? 49.115 -20.734 26.708 1.00 47.22 ? 667 PHE B N 1 ATOM 4605 C CA . PHE A 1 611 ? 48.302 -21.858 27.157 1.00 39.40 ? 667 PHE B CA 1 ATOM 4606 C C . PHE A 1 611 ? 47.345 -21.522 28.293 1.00 42.34 ? 667 PHE B C 1 ATOM 4607 O O . PHE A 1 611 ? 46.341 -22.210 28.492 1.00 39.89 ? 667 PHE B O 1 ATOM 4608 C CB . PHE A 1 611 ? 49.189 -23.053 27.494 1.00 31.18 ? 667 PHE B CB 1 ATOM 4609 C CG . PHE A 1 611 ? 50.012 -23.524 26.333 1.00 25.28 ? 667 PHE B CG 1 ATOM 4610 C CD1 . PHE A 1 611 ? 49.510 -24.459 25.438 1.00 24.66 ? 667 PHE B CD1 1 ATOM 4611 C CD2 . PHE A 1 611 ? 51.277 -23.014 26.119 1.00 23.19 ? 667 PHE B CD2 1 ATOM 4612 C CE1 . PHE A 1 611 ? 50.267 -24.889 24.363 1.00 16.61 ? 667 PHE B CE1 1 ATOM 4613 C CE2 . PHE A 1 611 ? 52.035 -23.438 25.043 1.00 32.63 ? 667 PHE B CE2 1 ATOM 4614 C CZ . PHE A 1 611 ? 51.527 -24.380 24.165 1.00 17.36 ? 667 PHE B CZ 1 ATOM 4615 N N . ARG A 1 612 ? 47.638 -20.451 29.026 1.00 51.32 ? 668 ARG B N 1 ATOM 4616 C CA . ARG A 1 612 ? 46.740 -20.003 30.091 1.00 56.14 ? 668 ARG B CA 1 ATOM 4617 C C . ARG A 1 612 ? 45.531 -19.310 29.467 1.00 48.51 ? 668 ARG B C 1 ATOM 4618 O O . ARG A 1 612 ? 44.553 -18.998 30.151 1.00 37.49 ? 668 ARG B O 1 ATOM 4619 C CB . ARG A 1 612 ? 47.461 -19.065 31.069 1.00 66.55 ? 668 ARG B CB 1 ATOM 4620 C CG . ARG A 1 612 ? 47.866 -17.726 30.459 1.00 77.65 ? 668 ARG B CG 1 ATOM 4621 C CD . ARG A 1 612 ? 48.415 -16.740 31.492 1.00 82.19 ? 668 ARG B CD 1 ATOM 4622 N NE . ARG A 1 612 ? 49.834 -16.949 31.772 1.00 82.83 ? 668 ARG B NE 1 ATOM 4623 C CZ . ARG A 1 612 ? 50.650 -16.011 32.246 1.00 79.30 ? 668 ARG B CZ 1 ATOM 4624 N NH1 . ARG A 1 612 ? 50.191 -14.789 32.487 1.00 78.06 ? 668 ARG B NH1 1 ATOM 4625 N NH2 . ARG A 1 612 ? 51.927 -16.291 32.472 1.00 75.01 ? 668 ARG B NH2 1 ATOM 4626 N N . ARG A 1 613 ? 45.636 -19.037 28.169 1.00 54.09 ? 669 ARG B N 1 ATOM 4627 C CA . ARG A 1 613 ? 44.532 -18.497 27.386 1.00 55.93 ? 669 ARG B CA 1 ATOM 4628 C C . ARG A 1 613 ? 43.570 -19.591 26.894 1.00 49.72 ? 669 ARG B C 1 ATOM 4629 O O . ARG A 1 613 ? 42.370 -19.344 26.762 1.00 55.29 ? 669 ARG B O 1 ATOM 4630 C CB . ARG A 1 613 ? 45.072 -17.656 26.226 1.00 65.08 ? 669 ARG B CB 1 ATOM 4631 C CG . ARG A 1 613 ? 44.030 -16.992 25.357 1.00 73.19 ? 669 ARG B CG 1 ATOM 4632 C CD . ARG A 1 613 ? 44.706 -16.178 24.255 1.00 78.53 ? 669 ARG B CD 1 ATOM 4633 N NE . ARG A 1 613 ? 45.619 -15.176 24.806 1.00 78.60 ? 669 ARG B NE 1 ATOM 4634 C CZ . ARG A 1 613 ? 46.862 -14.977 24.378 1.00 75.00 ? 669 ARG B CZ 1 ATOM 4635 N NH1 . ARG A 1 613 ? 47.621 -14.047 24.944 1.00 77.15 ? 669 ARG B NH1 1 ATOM 4636 N NH2 . ARG A 1 613 ? 47.348 -15.705 23.382 1.00 68.37 ? 669 ARG B NH2 1 ATOM 4637 N N . LEU A 1 614 ? 44.095 -20.784 26.606 1.00 40.65 ? 670 LEU B N 1 ATOM 4638 C CA . LEU A 1 614 ? 43.245 -21.924 26.258 1.00 34.03 ? 670 LEU B CA 1 ATOM 4639 C C . LEU A 1 614 ? 42.199 -22.083 27.353 1.00 36.59 ? 670 LEU B C 1 ATOM 4640 O O . LEU A 1 614 ? 42.538 -22.074 28.537 1.00 35.76 ? 670 LEU B O 1 ATOM 4641 C CB . LEU A 1 614 ? 44.055 -23.224 26.145 1.00 30.21 ? 670 LEU B CB 1 ATOM 4642 C CG . LEU A 1 614 ? 45.207 -23.325 25.144 1.00 34.55 ? 670 LEU B CG 1 ATOM 4643 C CD1 . LEU A 1 614 ? 45.746 -24.761 25.036 1.00 13.73 ? 670 LEU B CD1 1 ATOM 4644 C CD2 . LEU A 1 614 ? 44.780 -22.796 23.779 1.00 33.30 ? 670 LEU B CD2 1 ATOM 4645 N N . PRO A 1 615 ? 40.921 -22.224 26.965 1.00 37.73 ? 671 PRO B N 1 ATOM 4646 C CA . PRO A 1 615 ? 39.839 -22.357 27.953 1.00 33.35 ? 671 PRO B CA 1 ATOM 4647 C C . PRO A 1 615 ? 40.078 -23.555 28.861 1.00 39.48 ? 671 PRO B C 1 ATOM 4648 O O . PRO A 1 615 ? 40.810 -24.466 28.483 1.00 48.33 ? 671 PRO B O 1 ATOM 4649 C CB . PRO A 1 615 ? 38.598 -22.602 27.087 1.00 30.00 ? 671 PRO B CB 1 ATOM 4650 C CG . PRO A 1 615 ? 38.957 -22.061 25.722 1.00 33.45 ? 671 PRO B CG 1 ATOM 4651 C CD . PRO A 1 615 ? 40.431 -22.299 25.575 1.00 34.16 ? 671 PRO B CD 1 ATOM 4652 N N . LEU A 1 616 ? 39.494 -23.551 30.052 1.00 38.37 ? 672 LEU B N 1 ATOM 4653 C CA . LEU A 1 616 ? 39.680 -24.667 30.966 1.00 35.01 ? 672 LEU B CA 1 ATOM 4654 C C . LEU A 1 616 ? 38.779 -25.840 30.590 1.00 34.31 ? 672 LEU B C 1 ATOM 4655 O O . LEU A 1 616 ? 39.147 -26.992 30.785 1.00 41.42 ? 672 LEU B O 1 ATOM 4656 C CB . LEU A 1 616 ? 39.447 -24.236 32.411 1.00 42.29 ? 672 LEU B CB 1 ATOM 4657 C CG . LEU A 1 616 ? 40.237 -24.986 33.491 1.00 44.83 ? 672 LEU B CG 1 ATOM 4658 C CD1 . LEU A 1 616 ? 41.735 -24.899 33.240 1.00 43.24 ? 672 LEU B CD1 1 ATOM 4659 C CD2 . LEU A 1 616 ? 39.901 -24.424 34.863 1.00 49.46 ? 672 LEU B CD2 1 ATOM 4660 N N . SER A 1 617 ? 37.601 -25.549 30.047 1.00 32.25 ? 673 SER B N 1 ATOM 4661 C CA . SER A 1 617 ? 36.732 -26.605 29.537 1.00 35.29 ? 673 SER B CA 1 ATOM 4662 C C . SER A 1 617 ? 37.390 -27.280 28.339 1.00 33.56 ? 673 SER B C 1 ATOM 4663 O O . SER A 1 617 ? 37.175 -28.466 28.085 1.00 38.64 ? 673 SER B O 1 ATOM 4664 C CB . SER A 1 617 ? 35.362 -26.055 29.147 1.00 41.41 ? 673 SER B CB 1 ATOM 4665 O OG . SER A 1 617 ? 35.488 -24.978 28.236 1.00 48.13 ? 673 SER B OG 1 ATOM 4666 N N . ASP A 1 618 ? 38.197 -26.519 27.607 1.00 27.97 ? 674 ASP B N 1 ATOM 4667 C CA . ASP A 1 618 ? 38.985 -27.081 26.517 1.00 28.57 ? 674 ASP B CA 1 ATOM 4668 C C . ASP A 1 618 ? 39.893 -28.194 27.028 1.00 29.80 ? 674 ASP B C 1 ATOM 4669 O O . ASP A 1 618 ? 39.889 -29.301 26.490 1.00 33.07 ? 674 ASP B O 1 ATOM 4670 C CB . ASP A 1 618 ? 39.812 -25.995 25.821 1.00 26.32 ? 674 ASP B CB 1 ATOM 4671 C CG . ASP A 1 618 ? 39.198 -25.546 24.508 1.00 33.29 ? 674 ASP B CG 1 ATOM 4672 O OD1 . ASP A 1 618 ? 37.970 -25.715 24.335 1.00 35.18 ? 674 ASP B OD1 1 ATOM 4673 O OD2 . ASP A 1 618 ? 39.944 -25.035 23.645 1.00 38.96 ? 674 ASP B OD2 1 ATOM 4674 N N . LEU A 1 619 ? 40.659 -27.905 28.076 1.00 25.05 ? 675 LEU B N 1 ATOM 4675 C CA . LEU A 1 619 ? 41.550 -28.897 28.657 1.00 13.29 ? 675 LEU B CA 1 ATOM 4676 C C . LEU A 1 619 ? 40.742 -30.019 29.302 1.00 15.85 ? 675 LEU B C 1 ATOM 4677 O O . LEU A 1 619 ? 41.185 -31.169 29.356 1.00 14.00 ? 675 LEU B O 1 ATOM 4678 C CB . LEU A 1 619 ? 42.477 -28.242 29.674 1.00 20.76 ? 675 LEU B CB 1 ATOM 4679 C CG . LEU A 1 619 ? 43.415 -27.133 29.186 1.00 16.82 ? 675 LEU B CG 1 ATOM 4680 C CD1 . LEU A 1 619 ? 44.313 -26.649 30.321 1.00 18.84 ? 675 LEU B CD1 1 ATOM 4681 C CD2 . LEU A 1 619 ? 44.257 -27.616 28.026 1.00 16.26 ? 675 LEU B CD2 1 ATOM 4682 N N . ALA A 1 620 ? 39.540 -29.674 29.751 1.00 16.97 ? 676 ALA B N 1 ATOM 4683 C CA . ALA A 1 620 ? 38.663 -30.584 30.487 1.00 18.20 ? 676 ALA B CA 1 ATOM 4684 C C . ALA A 1 620 ? 38.042 -31.687 29.636 1.00 22.41 ? 676 ALA B C 1 ATOM 4685 O O . ALA A 1 620 ? 37.607 -32.716 30.166 1.00 28.76 ? 676 ALA B O 1 ATOM 4686 C CB . ALA A 1 620 ? 37.564 -29.792 31.179 1.00 12.33 ? 676 ALA B CB 1 ATOM 4687 N N . SER A 1 621 ? 37.985 -31.470 28.324 1.00 19.37 ? 677 SER B N 1 ATOM 4688 C CA . SER A 1 621 ? 37.356 -32.428 27.413 1.00 12.19 ? 677 SER B CA 1 ATOM 4689 C C . SER A 1 621 ? 38.318 -33.532 27.002 1.00 20.88 ? 677 SER B C 1 ATOM 4690 O O . SER A 1 621 ? 37.924 -34.514 26.377 1.00 25.93 ? 677 SER B O 1 ATOM 4691 C CB . SER A 1 621 ? 36.784 -31.716 26.184 1.00 11.40 ? 677 SER B CB 1 ATOM 4692 O OG . SER A 1 621 ? 37.714 -30.807 25.624 1.00 12.51 ? 677 SER B OG 1 ATOM 4693 N N . ASN A 1 622 ? 39.581 -33.364 27.376 1.00 13.54 ? 678 ASN B N 1 ATOM 4694 C CA . ASN A 1 622 ? 40.637 -34.340 27.108 1.00 14.35 ? 678 ASN B CA 1 ATOM 4695 C C . ASN A 1 622 ? 40.791 -35.448 28.165 1.00 15.08 ? 678 ASN B C 1 ATOM 4696 O O . ASN A 1 622 ? 39.902 -35.663 28.982 1.00 24.25 ? 678 ASN B O 1 ATOM 4697 C CB . ASN A 1 622 ? 41.969 -33.627 26.882 1.00 23.08 ? 678 ASN B CB 1 ATOM 4698 C CG . ASN A 1 622 ? 41.999 -32.850 25.587 1.00 22.31 ? 678 ASN B CG 1 ATOM 4699 O OD1 . ASN A 1 622 ? 42.190 -33.424 24.524 1.00 21.20 ? 678 ASN B OD1 1 ATOM 4700 N ND2 . ASN A 1 622 ? 41.814 -31.540 25.669 1.00 13.63 ? 678 ASN B ND2 1 ATOM 4701 N N . ARG A 1 623 ? 41.902 -36.181 28.103 1.00 15.88 ? 679 ARG B N 1 ATOM 4702 C CA . ARG A 1 623 ? 42.211 -37.214 29.088 1.00 18.22 ? 679 ARG B CA 1 ATOM 4703 C C . ARG A 1 623 ? 42.974 -36.656 30.297 1.00 26.03 ? 679 ARG B C 1 ATOM 4704 O O . ARG A 1 623 ? 42.493 -36.713 31.424 1.00 31.82 ? 679 ARG B O 1 ATOM 4705 C CB . ARG A 1 623 ? 43.018 -38.351 28.447 1.00 17.37 ? 679 ARG B CB 1 ATOM 4706 C CG . ARG A 1 623 ? 43.304 -39.531 29.374 1.00 21.31 ? 679 ARG B CG 1 ATOM 4707 C CD . ARG A 1 623 ? 44.079 -40.654 28.682 1.00 27.38 ? 679 ARG B CD 1 ATOM 4708 N NE . ARG A 1 623 ? 45.518 -40.609 28.951 1.00 42.90 ? 679 ARG B NE 1 ATOM 4709 C CZ . ARG A 1 623 ? 46.224 -41.610 29.478 1.00 51.95 ? 679 ARG B CZ 1 ATOM 4710 N NH1 . ARG A 1 623 ? 45.637 -42.751 29.804 1.00 49.81 ? 679 ARG B NH1 1 ATOM 4711 N NH2 . ARG A 1 623 ? 47.528 -41.474 29.675 1.00 59.84 ? 679 ARG B NH2 1 ATOM 4712 N N . GLY A 1 624 ? 44.207 -36.228 30.048 1.00 26.10 ? 680 GLY B N 1 ATOM 4713 C CA . GLY A 1 624 ? 45.125 -35.690 31.042 1.00 17.98 ? 680 GLY B CA 1 ATOM 4714 C C . GLY A 1 624 ? 45.636 -34.259 31.001 1.00 17.74 ? 680 GLY B C 1 ATOM 4715 O O . GLY A 1 624 ? 46.763 -34.043 31.401 1.00 23.75 ? 680 GLY B O 1 ATOM 4716 N N . LEU A 1 625 ? 44.947 -33.304 30.407 1.00 33.21 ? 681 LEU B N 1 ATOM 4717 C CA . LEU A 1 625 ? 45.604 -32.008 30.210 1.00 16.80 ? 681 LEU B CA 1 ATOM 4718 C C . LEU A 1 625 ? 45.539 -31.071 31.402 1.00 24.70 ? 681 LEU B C 1 ATOM 4719 O O . LEU A 1 625 ? 44.471 -30.894 32.012 1.00 19.38 ? 681 LEU B O 1 ATOM 4720 C CB . LEU A 1 625 ? 45.079 -31.306 28.956 1.00 17.63 ? 681 LEU B CB 1 ATOM 4721 C CG . LEU A 1 625 ? 45.692 -31.853 27.669 1.00 16.25 ? 681 LEU B CG 1 ATOM 4722 C CD1 . LEU A 1 625 ? 45.087 -31.181 26.471 1.00 15.45 ? 681 LEU B CD1 1 ATOM 4723 C CD2 . LEU A 1 625 ? 47.196 -31.644 27.701 1.00 33.69 ? 681 LEU B CD2 1 ATOM 4724 N N . TYR A 1 626 ? 46.696 -30.500 31.750 1.00 17.31 ? 682 TYR B N 1 ATOM 4725 C CA . TYR A 1 626 ? 46.793 -29.506 32.825 1.00 25.31 ? 682 TYR B CA 1 ATOM 4726 C C . TYR A 1 626 ? 48.003 -28.588 32.663 1.00 17.78 ? 682 TYR B C 1 ATOM 4727 O O . TYR A 1 626 ? 49.056 -29.034 32.224 1.00 18.43 ? 682 TYR B O 1 ATOM 4728 C CB . TYR A 1 626 ? 46.857 -30.210 34.185 1.00 17.93 ? 682 TYR B CB 1 ATOM 4729 C CG . TYR A 1 626 ? 48.167 -30.913 34.443 1.00 18.95 ? 682 TYR B CG 1 ATOM 4730 C CD1 . TYR A 1 626 ? 48.433 -32.149 33.880 1.00 19.33 ? 682 TYR B CD1 1 ATOM 4731 C CD2 . TYR A 1 626 ? 49.143 -30.334 35.232 1.00 19.58 ? 682 TYR B CD2 1 ATOM 4732 C CE1 . TYR A 1 626 ? 49.622 -32.795 34.105 1.00 20.28 ? 682 TYR B CE1 1 ATOM 4733 C CE2 . TYR A 1 626 ? 50.337 -30.968 35.452 1.00 20.53 ? 682 TYR B CE2 1 ATOM 4734 C CZ . TYR A 1 626 ? 50.572 -32.201 34.889 1.00 20.87 ? 682 TYR B CZ 1 ATOM 4735 O OH . TYR A 1 626 ? 51.768 -32.839 35.118 1.00 21.86 ? 682 TYR B OH 1 ATOM 4736 N N . ILE A 1 627 ? 47.871 -27.327 33.068 1.00 17.49 ? 683 ILE B N 1 ATOM 4737 C CA . ILE A 1 627 ? 49.014 -26.409 33.063 1.00 35.89 ? 683 ILE B CA 1 ATOM 4738 C C . ILE A 1 627 ? 49.967 -26.666 34.226 1.00 18.95 ? 683 ILE B C 1 ATOM 4739 O O . ILE A 1 627 ? 49.537 -26.860 35.353 1.00 45.89 ? 683 ILE B O 1 ATOM 4740 C CB . ILE A 1 627 ? 48.588 -24.925 33.118 1.00 31.65 ? 683 ILE B CB 1 ATOM 4741 C CG1 . ILE A 1 627 ? 47.586 -24.599 32.012 1.00 31.16 ? 683 ILE B CG1 1 ATOM 4742 C CG2 . ILE A 1 627 ? 49.815 -24.003 33.034 1.00 27.95 ? 683 ILE B CG2 1 ATOM 4743 C CD1 . ILE A 1 627 ? 46.178 -24.427 32.524 1.00 37.74 ? 683 ILE B CD1 1 ATOM 4744 N N . SER A 1 628 ? 51.262 -26.661 33.941 1.00 28.60 ? 684 SER B N 1 ATOM 4745 C CA . SER A 1 628 ? 52.272 -26.936 34.945 1.00 31.18 ? 684 SER B CA 1 ATOM 4746 C C . SER A 1 628 ? 53.018 -25.682 35.391 1.00 34.04 ? 684 SER B C 1 ATOM 4747 O O . SER A 1 628 ? 52.810 -24.590 34.860 1.00 36.52 ? 684 SER B O 1 ATOM 4748 C CB . SER A 1 628 ? 53.300 -27.902 34.379 1.00 31.62 ? 684 SER B CB 1 ATOM 4749 O OG . SER A 1 628 ? 54.330 -27.171 33.737 1.00 33.40 ? 684 SER B OG 1 ATOM 4750 N N . ASN A 1 629 ? 53.916 -25.870 36.355 1.00 32.37 ? 685 ASN B N 1 ATOM 4751 C CA . ASN A 1 629 ? 54.771 -24.809 36.859 1.00 22.61 ? 685 ASN B CA 1 ATOM 4752 C C . ASN A 1 629 ? 56.206 -25.304 36.836 1.00 30.58 ? 685 ASN B C 1 ATOM 4753 O O . ASN A 1 629 ? 56.522 -26.333 37.436 1.00 33.71 ? 685 ASN B O 1 ATOM 4754 C CB . ASN A 1 629 ? 54.396 -24.441 38.294 1.00 22.69 ? 685 ASN B CB 1 ATOM 4755 C CG . ASN A 1 629 ? 53.112 -23.646 38.385 1.00 23.82 ? 685 ASN B CG 1 ATOM 4756 O OD1 . ASN A 1 629 ? 53.099 -22.432 38.178 1.00 21.50 ? 685 ASN B OD1 1 ATOM 4757 N ND2 . ASN A 1 629 ? 52.022 -24.324 38.719 1.00 27.43 ? 685 ASN B ND2 1 ATOM 4758 N N . ALA A 1 630 ? 57.076 -24.576 36.146 1.00 28.97 ? 686 ALA B N 1 ATOM 4759 C CA . ALA A 1 630 ? 58.459 -25.007 36.004 1.00 25.19 ? 686 ALA B CA 1 ATOM 4760 C C . ALA A 1 630 ? 59.180 -24.965 37.345 1.00 34.29 ? 686 ALA B C 1 ATOM 4761 O O . ALA A 1 630 ? 58.924 -24.095 38.180 1.00 35.20 ? 686 ALA B O 1 ATOM 4762 C CB . ALA A 1 630 ? 59.186 -24.165 34.971 1.00 25.41 ? 686 ALA B CB 1 ATOM 4763 N N . ILE A 1 631 ? 60.077 -25.926 37.542 1.00 26.97 ? 687 ILE B N 1 ATOM 4764 C CA . ILE A 1 631 ? 60.881 -25.999 38.746 1.00 31.58 ? 687 ILE B CA 1 ATOM 4765 C C . ILE A 1 631 ? 61.895 -24.860 38.753 1.00 28.65 ? 687 ILE B C 1 ATOM 4766 O O . ILE A 1 631 ? 62.673 -24.707 37.823 1.00 29.05 ? 687 ILE B O 1 ATOM 4767 C CB . ILE A 1 631 ? 61.560 -27.374 38.858 1.00 28.67 ? 687 ILE B CB 1 ATOM 4768 C CG1 . ILE A 1 631 ? 60.485 -28.462 38.888 1.00 27.98 ? 687 ILE B CG1 1 ATOM 4769 C CG2 . ILE A 1 631 ? 62.452 -27.438 40.082 1.00 29.72 ? 687 ILE B CG2 1 ATOM 4770 C CD1 . ILE A 1 631 ? 61.005 -29.843 39.138 1.00 75.50 ? 687 ILE B CD1 1 ATOM 4771 N N . SER A 1 632 ? 61.867 -24.055 39.809 1.00 31.08 ? 688 SER B N 1 ATOM 4772 C CA . SER A 1 632 ? 62.695 -22.862 39.889 1.00 36.47 ? 688 SER B CA 1 ATOM 4773 C C . SER A 1 632 ? 64.159 -23.234 40.084 1.00 43.45 ? 688 SER B C 1 ATOM 4774 O O . SER A 1 632 ? 64.495 -24.011 40.976 1.00 47.45 ? 688 SER B O 1 ATOM 4775 C CB . SER A 1 632 ? 62.217 -21.965 41.038 1.00 36.83 ? 688 SER B CB 1 ATOM 4776 O OG . SER A 1 632 ? 63.307 -21.373 41.732 1.00 37.03 ? 688 SER B OG 1 ATOM 4777 N N . ASP B 2 1 ? 50.359 15.314 -13.336 1.00 60.20 ? 44 ASP A N 1 ATOM 4778 C CA . ASP B 2 1 ? 49.373 16.378 -13.476 1.00 65.18 ? 44 ASP A CA 1 ATOM 4779 C C . ASP B 2 1 ? 48.227 16.171 -12.494 1.00 61.75 ? 44 ASP A C 1 ATOM 4780 O O . ASP B 2 1 ? 48.213 15.193 -11.747 1.00 67.97 ? 44 ASP A O 1 ATOM 4781 C CB . ASP B 2 1 ? 48.812 16.395 -14.900 1.00 69.83 ? 44 ASP A CB 1 ATOM 4782 C CG . ASP B 2 1 ? 49.856 16.755 -15.941 1.00 76.92 ? 44 ASP A CG 1 ATOM 4783 O OD1 . ASP B 2 1 ? 51.063 16.665 -15.633 1.00 79.59 ? 44 ASP A OD1 1 ATOM 4784 O OD2 . ASP B 2 1 ? 49.465 17.121 -17.073 1.00 79.20 ? 44 ASP A OD2 1 HETATM 4785 N N . PTR B 2 2 ? 47.269 17.094 -12.480 1.00 48.11 ? 45 PTR A N 1 HETATM 4786 C CA . PTR B 2 2 ? 45.976 16.767 -11.901 1.00 36.06 ? 45 PTR A CA 1 HETATM 4787 C C . PTR B 2 2 ? 45.288 15.942 -12.987 1.00 32.06 ? 45 PTR A C 1 HETATM 4788 O O . PTR B 2 2 ? 45.482 16.205 -14.180 1.00 25.18 ? 45 PTR A O 1 HETATM 4789 C CB . PTR B 2 2 ? 45.153 17.949 -11.358 1.00 33.05 ? 45 PTR A CB 1 HETATM 4790 C CG . PTR B 2 2 ? 44.537 18.877 -12.383 1.00 27.31 ? 45 PTR A CG 1 HETATM 4791 C CD1 . PTR B 2 2 ? 43.197 18.770 -12.738 1.00 10.73 ? 45 PTR A CD1 1 HETATM 4792 C CD2 . PTR B 2 2 ? 45.284 19.882 -12.962 1.00 12.99 ? 45 PTR A CD2 1 HETATM 4793 C CE1 . PTR B 2 2 ? 42.626 19.639 -13.651 1.00 10.49 ? 45 PTR A CE1 1 HETATM 4794 C CE2 . PTR B 2 2 ? 44.729 20.750 -13.872 1.00 16.94 ? 45 PTR A CE2 1 HETATM 4795 C CZ . PTR B 2 2 ? 43.399 20.634 -14.210 1.00 14.09 ? 45 PTR A CZ 1 HETATM 4796 O OH . PTR B 2 2 ? 42.911 21.449 -15.099 1.00 11.73 ? 45 PTR A OH 1 HETATM 4797 P P . PTR B 2 2 ? 42.068 22.767 -14.757 1.00 11.21 ? 45 PTR A P 1 HETATM 4798 O O1P . PTR B 2 2 ? 41.295 23.163 -16.025 1.00 10.60 ? 45 PTR A O1P 1 HETATM 4799 O O2P . PTR B 2 2 ? 41.043 22.485 -13.649 1.00 20.69 ? 45 PTR A O2P 1 HETATM 4800 O O3P . PTR B 2 2 ? 42.999 23.851 -14.357 1.00 26.35 ? 45 PTR A O3P 1 ATOM 4801 N N . PRO B 2 3 ? 44.528 14.915 -12.578 1.00 33.93 ? 46 PRO A N 1 ATOM 4802 C CA . PRO B 2 3 ? 43.944 13.959 -13.532 1.00 9.58 ? 46 PRO A CA 1 ATOM 4803 C C . PRO B 2 3 ? 42.813 14.524 -14.382 1.00 29.33 ? 46 PRO A C 1 ATOM 4804 O O . PRO B 2 3 ? 42.025 15.358 -13.937 1.00 32.86 ? 46 PRO A O 1 ATOM 4805 C CB . PRO B 2 3 ? 43.434 12.827 -12.637 1.00 8.85 ? 46 PRO A CB 1 ATOM 4806 C CG . PRO B 2 3 ? 43.297 13.429 -11.282 1.00 9.02 ? 46 PRO A CG 1 ATOM 4807 C CD . PRO B 2 3 ? 44.307 14.527 -11.174 1.00 10.27 ? 46 PRO A CD 1 ATOM 4808 N N . LYS B 2 4 ? 42.756 14.054 -15.620 1.00 8.45 ? 47 LYS A N 1 ATOM 4809 C CA . LYS B 2 4 ? 41.717 14.425 -16.559 1.00 7.62 ? 47 LYS A CA 1 ATOM 4810 C C . LYS B 2 4 ? 40.362 14.018 -15.986 1.00 15.59 ? 47 LYS A C 1 ATOM 4811 O O . LYS B 2 4 ? 40.298 13.109 -15.160 1.00 14.34 ? 47 LYS A O 1 ATOM 4812 C CB . LYS B 2 4 ? 41.985 13.732 -17.906 1.00 14.36 ? 47 LYS A CB 1 ATOM 4813 C CG . LYS B 2 4 ? 43.013 14.435 -18.772 1.00 15.94 ? 47 LYS A CG 1 ATOM 4814 C CD . LYS B 2 4 ? 44.327 13.695 -18.837 1.00 27.27 ? 47 LYS A CD 1 ATOM 4815 C CE . LYS B 2 4 ? 44.246 12.495 -19.772 1.00 29.64 ? 47 LYS A CE 1 ATOM 4816 N NZ . LYS B 2 4 ? 45.597 11.891 -20.013 1.00 32.01 ? 47 LYS A NZ 1 ATOM 4817 N N . PRO B 2 5 ? 39.275 14.687 -16.418 1.00 13.00 ? 48 PRO A N 1 ATOM 4818 C CA . PRO B 2 5 ? 37.920 14.425 -15.897 1.00 7.48 ? 48 PRO A CA 1 ATOM 4819 C C . PRO B 2 5 ? 37.537 12.964 -16.040 1.00 12.37 ? 48 PRO A C 1 ATOM 4820 O O . PRO B 2 5 ? 37.902 12.355 -17.045 1.00 7.52 ? 48 PRO A O 1 ATOM 4821 C CB . PRO B 2 5 ? 37.019 15.257 -16.811 1.00 10.60 ? 48 PRO A CB 1 ATOM 4822 C CG . PRO B 2 5 ? 37.923 16.314 -17.410 1.00 13.90 ? 48 PRO A CG 1 ATOM 4823 C CD . PRO B 2 5 ? 39.280 15.701 -17.490 1.00 13.62 ? 48 PRO A CD 1 ATOM 4824 N N . SER B 2 6 ? 36.825 12.402 -15.065 1.00 14.60 ? 49 SER A N 1 ATOM 4825 C CA . SER B 2 6 ? 36.420 11.005 -15.176 1.00 10.99 ? 49 SER A CA 1 ATOM 4826 C C . SER B 2 6 ? 35.085 10.704 -14.527 1.00 10.55 ? 49 SER A C 1 ATOM 4827 O O . SER B 2 6 ? 34.612 11.440 -13.667 1.00 34.20 ? 49 SER A O 1 ATOM 4828 C CB . SER B 2 6 ? 37.500 10.070 -14.621 1.00 12.33 ? 49 SER A CB 1 ATOM 4829 O OG . SER B 2 6 ? 37.446 9.991 -13.206 1.00 18.10 ? 49 SER A OG 1 ATOM 4830 N N . THR B 2 7 ? 34.481 9.612 -14.975 1.00 6.62 ? 50 THR A N 1 ATOM 4831 C CA . THR B 2 7 ? 33.276 9.069 -14.366 1.00 11.16 ? 50 THR A CA 1 ATOM 4832 C C . THR B 2 7 ? 33.658 8.332 -13.074 1.00 8.34 ? 50 THR A C 1 ATOM 4833 O O . THR B 2 7 ? 34.813 7.951 -12.893 1.00 3.11 ? 50 THR A O 1 ATOM 4834 C CB . THR B 2 7 ? 32.532 8.098 -15.335 1.00 2.49 ? 50 THR A CB 1 ATOM 4835 O OG1 . THR B 2 7 ? 33.438 7.104 -15.818 1.00 5.37 ? 50 THR A OG1 1 ATOM 4836 C CG2 . THR B 2 7 ? 31.999 8.837 -16.519 1.00 2.33 ? 50 THR A CG2 1 ATOM 4837 N N . ARG B 2 8 ? 32.704 8.172 -12.162 1.00 2.45 ? 51 ARG A N 1 ATOM 4838 C CA . ARG B 2 8 ? 32.924 7.299 -11.025 1.00 19.59 ? 51 ARG A CA 1 ATOM 4839 C C . ARG B 2 8 ? 33.316 5.916 -11.531 1.00 5.80 ? 51 ARG A C 1 ATOM 4840 O O . ARG B 2 8 ? 32.661 5.372 -12.405 1.00 11.66 ? 51 ARG A O 1 ATOM 4841 C CB . ARG B 2 8 ? 31.675 7.175 -10.157 1.00 19.75 ? 51 ARG A CB 1 ATOM 4842 C CG . ARG B 2 8 ? 31.820 6.043 -9.159 1.00 2.34 ? 51 ARG A CG 1 ATOM 4843 C CD . ARG B 2 8 ? 30.536 5.616 -8.576 1.00 3.38 ? 51 ARG A CD 1 ATOM 4844 N NE . ARG B 2 8 ? 30.307 4.187 -8.734 1.00 2.09 ? 51 ARG A NE 1 ATOM 4845 C CZ . ARG B 2 8 ? 30.228 3.331 -7.724 1.00 15.96 ? 51 ARG A CZ 1 ATOM 4846 N NH1 . ARG B 2 8 ? 30.392 3.757 -6.474 1.00 17.03 ? 51 ARG A NH1 1 ATOM 4847 N NH2 . ARG B 2 8 ? 29.991 2.047 -7.959 1.00 19.30 ? 51 ARG A NH2 1 ATOM 4848 N N . PRO B 2 9 ? 34.401 5.359 -10.987 1.00 3.11 ? 52 PRO A N 1 ATOM 4849 C CA . PRO B 2 9 ? 34.864 4.040 -11.404 1.00 3.35 ? 52 PRO A CA 1 ATOM 4850 C C . PRO B 2 9 ? 33.783 3.008 -11.164 1.00 27.68 ? 52 PRO A C 1 ATOM 4851 O O . PRO B 2 9 ? 33.174 3.043 -10.101 1.00 27.68 ? 52 PRO A O 1 ATOM 4852 C CB . PRO B 2 9 ? 36.063 3.801 -10.497 1.00 3.72 ? 52 PRO A CB 1 ATOM 4853 C CG . PRO B 2 9 ? 36.550 5.187 -10.163 1.00 3.76 ? 52 PRO A CG 1 ATOM 4854 C CD . PRO B 2 9 ? 35.317 5.989 -10.021 1.00 3.32 ? 52 PRO A CD 1 HETATM 4855 N N . HZP B 2 10 ? 33.511 2.129 -12.129 1.00 22.98 ? 53 HZP A N 1 HETATM 4856 C CA . HZP B 2 10 ? 32.427 1.166 -11.935 1.00 13.91 ? 53 HZP A CA 1 HETATM 4857 C C . HZP B 2 10 ? 32.787 -0.014 -11.017 1.00 8.83 ? 53 HZP A C 1 HETATM 4858 O O . HZP B 2 10 ? 33.946 -0.480 -10.981 1.00 8.55 ? 53 HZP A O 1 HETATM 4859 C CB . HZP B 2 10 ? 32.054 0.694 -13.321 1.00 2.89 ? 53 HZP A CB 1 HETATM 4860 C CG . HZP B 2 10 ? 32.474 1.811 -14.227 1.00 19.19 ? 53 HZP A CG 1 HETATM 4861 C CD . HZP B 2 10 ? 33.607 2.547 -13.542 1.00 8.42 ? 53 HZP A CD 1 HETATM 4862 O OD1 . HZP B 2 10 ? 32.899 1.238 -15.442 1.00 42.39 ? 53 HZP A OD1 1 ATOM 4863 N N . ARG B 2 11 ? 31.779 -0.465 -10.277 1.00 14.28 ? 54 ARG A N 1 ATOM 4864 C CA . ARG B 2 11 ? 31.925 -1.520 -9.301 1.00 15.13 ? 54 ARG A CA 1 ATOM 4865 C C . ARG B 2 11 ? 31.020 -2.694 -9.665 1.00 12.51 ? 54 ARG A C 1 ATOM 4866 O O . ARG B 2 11 ? 29.864 -2.504 -10.088 1.00 15.59 ? 54 ARG A O 1 ATOM 4867 C CB . ARG B 2 11 ? 31.534 -1.032 -7.899 1.00 12.81 ? 54 ARG A CB 1 ATOM 4868 C CG . ARG B 2 11 ? 32.580 -0.261 -7.132 1.00 9.95 ? 54 ARG A CG 1 ATOM 4869 C CD . ARG B 2 11 ? 32.561 -0.613 -5.620 1.00 61.31 ? 54 ARG A CD 1 ATOM 4870 N NE . ARG B 2 11 ? 31.213 -0.733 -5.040 1.00 57.73 ? 54 ARG A NE 1 ATOM 4871 C CZ . ARG B 2 11 ? 30.564 0.254 -4.419 1.00 50.85 ? 54 ARG A CZ 1 ATOM 4872 N NH1 . ARG B 2 11 ? 31.129 1.454 -4.308 1.00 52.09 ? 54 ARG A NH1 1 ATOM 4873 N NH2 . ARG B 2 11 ? 29.346 0.052 -3.914 1.00 39.15 ? 54 ARG A NH2 1 ATOM 4874 N N . HIS B 2 12 ? 31.532 -3.909 -9.501 1.00 6.85 ? 55 HIS A N 1 ATOM 4875 C CA . HIS B 2 12 ? 30.691 -5.091 -9.644 1.00 3.02 ? 55 HIS A CA 1 ATOM 4876 C C . HIS B 2 12 ? 31.090 -6.085 -8.551 1.00 9.67 ? 55 HIS A C 1 ATOM 4877 O O . HIS B 2 12 ? 32.095 -5.906 -7.867 1.00 3.43 ? 55 HIS A O 1 ATOM 4878 C CB . HIS B 2 12 ? 30.846 -5.693 -11.051 1.00 19.22 ? 55 HIS A CB 1 ATOM 4879 C CG . HIS B 2 12 ? 32.256 -6.099 -11.377 1.00 16.99 ? 55 HIS A CG 1 ATOM 4880 N ND1 . HIS B 2 12 ? 32.808 -7.282 -10.939 1.00 16.95 ? 55 HIS A ND1 1 ATOM 4881 C CD2 . HIS B 2 12 ? 33.219 -5.463 -12.074 1.00 14.48 ? 55 HIS A CD2 1 ATOM 4882 C CE1 . HIS B 2 12 ? 34.062 -7.362 -11.356 1.00 11.69 ? 55 HIS A CE1 1 ATOM 4883 N NE2 . HIS B 2 12 ? 34.334 -6.269 -12.053 1.00 11.69 ? 55 HIS A NE2 1 ATOM 4884 N N . ASN B 2 13 ? 30.301 -7.130 -8.381 1.00 11.73 ? 56 ASN A N 1 ATOM 4885 C CA . ASN B 2 13 ? 30.631 -8.169 -7.416 1.00 18.77 ? 56 ASN A CA 1 ATOM 4886 C C . ASN B 2 13 ? 31.586 -9.172 -8.038 1.00 19.14 ? 56 ASN A C 1 ATOM 4887 O O . ASN B 2 13 ? 32.003 -8.973 -9.178 1.00 18.04 ? 56 ASN A O 1 ATOM 4888 C CB . ASN B 2 13 ? 29.361 -8.858 -6.904 1.00 17.11 ? 56 ASN A CB 1 ATOM 4889 C CG . ASN B 2 13 ? 28.434 -7.899 -6.200 1.00 17.78 ? 56 ASN A CG 1 ATOM 4890 O OD1 . ASN B 2 13 ? 28.406 -7.845 -4.975 1.00 32.11 ? 56 ASN A OD1 1 ATOM 4891 N ND2 . ASN B 2 13 ? 27.685 -7.114 -6.970 1.00 17.87 ? 56 ASN A ND2 1 ATOM 4892 O OXT . ASN B 2 13 ? 31.975 -10.171 -7.425 1.00 11.03 ? 56 ASN A OXT 1 HETATM 4893 C C1 . NAG C 3 . ? 25.259 -23.289 -28.407 1.00 21.46 ? 701 NAG B C1 1 HETATM 4894 C C2 . NAG C 3 . ? 23.997 -22.563 -28.894 1.00 23.30 ? 701 NAG B C2 1 HETATM 4895 C C3 . NAG C 3 . ? 23.038 -23.500 -29.618 1.00 35.25 ? 701 NAG B C3 1 HETATM 4896 C C4 . NAG C 3 . ? 23.783 -24.284 -30.688 1.00 40.20 ? 701 NAG B C4 1 HETATM 4897 C C5 . NAG C 3 . ? 24.973 -24.999 -30.054 1.00 38.88 ? 701 NAG B C5 1 HETATM 4898 C C6 . NAG C 3 . ? 25.777 -25.805 -31.068 1.00 47.40 ? 701 NAG B C6 1 HETATM 4899 C C7 . NAG C 3 . ? 23.260 -20.683 -27.579 1.00 16.63 ? 701 NAG B C7 1 HETATM 4900 C C8 . NAG C 3 . ? 22.418 -20.175 -26.449 1.00 18.16 ? 701 NAG B C8 1 HETATM 4901 N N2 . NAG C 3 . ? 23.284 -21.990 -27.774 1.00 20.56 ? 701 NAG B N2 1 HETATM 4902 O O3 . NAG C 3 . ? 21.940 -22.785 -30.156 1.00 35.65 ? 701 NAG B O3 1 HETATM 4903 O O4 . NAG C 3 . ? 22.909 -25.228 -31.263 1.00 43.91 ? 701 NAG B O4 1 HETATM 4904 O O5 . NAG C 3 . ? 25.833 -24.063 -29.443 1.00 29.70 ? 701 NAG B O5 1 HETATM 4905 O O6 . NAG C 3 . ? 26.133 -24.999 -32.173 1.00 55.63 ? 701 NAG B O6 1 HETATM 4906 O O7 . NAG C 3 . ? 23.899 -19.910 -28.278 1.00 17.08 ? 701 NAG B O7 1 HETATM 4907 C C1 . NAG D 3 . ? 22.209 -26.291 -31.975 1.00 54.22 ? 702 NAG B C1 1 HETATM 4908 C C2 . NAG D 3 . ? 21.498 -27.612 -32.259 1.00 59.79 ? 702 NAG B C2 1 HETATM 4909 C C3 . NAG D 3 . ? 20.803 -27.623 -33.623 1.00 67.53 ? 702 NAG B C3 1 HETATM 4910 C C4 . NAG D 3 . ? 20.138 -26.289 -33.984 1.00 65.06 ? 702 NAG B C4 1 HETATM 4911 C C5 . NAG D 3 . ? 21.026 -25.100 -33.612 1.00 59.88 ? 702 NAG B C5 1 HETATM 4912 C C6 . NAG D 3 . ? 20.332 -23.760 -33.829 1.00 55.07 ? 702 NAG B C6 1 HETATM 4913 C C7 . NAG D 3 . ? 22.565 -29.424 -31.048 1.00 47.64 ? 702 NAG B C7 1 HETATM 4914 C C8 . NAG D 3 . ? 23.409 -30.664 -31.107 1.00 34.18 ? 702 NAG B C8 1 HETATM 4915 N N2 . NAG D 3 . ? 22.451 -28.710 -32.165 1.00 53.15 ? 702 NAG B N2 1 HETATM 4916 O O3 . NAG D 3 . ? 19.831 -28.650 -33.615 1.00 71.43 ? 702 NAG B O3 1 HETATM 4917 O O4 . NAG D 3 . ? 19.819 -26.265 -35.366 1.00 63.67 ? 702 NAG B O4 1 HETATM 4918 O O5 . NAG D 3 . ? 21.369 -25.191 -32.249 1.00 58.46 ? 702 NAG B O5 1 HETATM 4919 O O6 . NAG D 3 . ? 19.458 -23.494 -32.752 1.00 50.66 ? 702 NAG B O6 1 HETATM 4920 O O7 . NAG D 3 . ? 22.013 -29.095 -29.994 1.00 52.56 ? 702 NAG B O7 1 HETATM 4921 C C1 . NAG E 3 . ? 37.059 -26.408 11.842 1.00 7.72 ? 703 NAG B C1 1 HETATM 4922 C C2 . NAG E 3 . ? 36.626 -25.010 12.261 1.00 7.40 ? 703 NAG B C2 1 HETATM 4923 C C3 . NAG E 3 . ? 35.302 -25.025 13.003 1.00 7.04 ? 703 NAG B C3 1 HETATM 4924 C C4 . NAG E 3 . ? 34.262 -25.802 12.206 1.00 6.78 ? 703 NAG B C4 1 HETATM 4925 C C5 . NAG E 3 . ? 34.772 -27.221 11.954 1.00 7.13 ? 703 NAG B C5 1 HETATM 4926 C C6 . NAG E 3 . ? 33.758 -28.070 11.172 1.00 10.28 ? 703 NAG B C6 1 HETATM 4927 C C7 . NAG E 3 . ? 37.895 -23.043 12.956 1.00 32.44 ? 703 NAG B C7 1 HETATM 4928 C C8 . NAG E 3 . ? 39.297 -22.552 13.173 1.00 7.98 ? 703 NAG B C8 1 HETATM 4929 N N2 . NAG E 3 . ? 37.669 -24.356 13.034 1.00 27.91 ? 703 NAG B N2 1 HETATM 4930 O O3 . NAG E 3 . ? 34.917 -23.685 13.081 1.00 6.74 ? 703 NAG B O3 1 HETATM 4931 O O4 . NAG E 3 . ? 32.958 -25.793 12.763 1.00 6.42 ? 703 NAG B O4 1 HETATM 4932 O O5 . NAG E 3 . ? 36.009 -27.159 11.255 1.00 7.47 ? 703 NAG B O5 1 HETATM 4933 O O6 . NAG E 3 . ? 33.528 -27.526 9.884 1.00 8.60 ? 703 NAG B O6 1 HETATM 4934 O O7 . NAG E 3 . ? 37.003 -22.233 12.722 1.00 38.52 ? 703 NAG B O7 1 HETATM 4935 C C1 . NAG F 3 . ? 38.009 -24.452 18.113 1.00 14.26 ? 704 NAG B C1 1 HETATM 4936 C C2 . NAG F 3 . ? 36.607 -24.483 17.483 1.00 7.74 ? 704 NAG B C2 1 HETATM 4937 C C3 . NAG F 3 . ? 36.306 -23.294 16.561 1.00 12.60 ? 704 NAG B C3 1 HETATM 4938 C C4 . NAG F 3 . ? 36.806 -21.983 17.148 1.00 8.71 ? 704 NAG B C4 1 HETATM 4939 C C5 . NAG F 3 . ? 38.287 -22.155 17.461 1.00 11.35 ? 704 NAG B C5 1 HETATM 4940 C C6 . NAG F 3 . ? 38.926 -20.889 18.007 1.00 18.49 ? 704 NAG B C6 1 HETATM 4941 C C7 . NAG F 3 . ? 35.264 -26.399 16.724 1.00 25.37 ? 704 NAG B C7 1 HETATM 4942 C C8 . NAG F 3 . ? 35.194 -27.613 15.836 1.00 7.58 ? 704 NAG B C8 1 HETATM 4943 N N2 . NAG F 3 . ? 36.428 -25.739 16.767 1.00 24.80 ? 704 NAG B N2 1 HETATM 4944 O O3 . NAG F 3 . ? 34.916 -23.188 16.347 1.00 17.28 ? 704 NAG B O3 1 HETATM 4945 O O4 . NAG F 3 . ? 36.539 -20.886 16.286 1.00 7.15 ? 704 NAG B O4 1 HETATM 4946 O O5 . NAG F 3 . ? 38.414 -23.140 18.465 1.00 10.71 ? 704 NAG B O5 1 HETATM 4947 O O6 . NAG F 3 . ? 38.392 -20.679 19.300 1.00 30.16 ? 704 NAG B O6 1 HETATM 4948 O O7 . NAG F 3 . ? 34.272 -26.053 17.363 1.00 7.21 ? 704 NAG B O7 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 CYS 1 61 61 CYS CYS B . n A 1 2 ASN 2 62 62 ASN ASN B . n A 1 3 TRP 3 63 63 TRP TRP B . n A 1 4 THR 4 64 64 THR THR B . n A 1 5 GLY 5 65 65 GLY GLY B . n A 1 6 VAL 6 66 66 VAL VAL B . n A 1 7 LYS 7 67 67 LYS LYS B . n A 1 8 CYS 8 68 68 CYS CYS B . n A 1 9 ASN 9 69 69 ASN ASN B . n A 1 10 ARG 10 70 70 ARG ARG B . n A 1 11 ARG 11 71 71 ARG ARG B . n A 1 12 GLY 12 72 72 GLY GLY B . n A 1 13 GLU 13 73 73 GLU GLU B . n A 1 14 VAL 14 74 74 VAL VAL B . n A 1 15 SER 15 75 75 SER SER B . n A 1 16 GLU 16 76 76 GLU GLU B . n A 1 17 ILE 17 77 77 ILE ILE B . n A 1 18 GLN 18 78 78 GLN GLN B . n A 1 19 LEU 19 79 79 LEU LEU B . n A 1 20 LYS 20 80 80 LYS LYS B . n A 1 21 GLU 21 81 81 GLU GLU B . n A 1 22 LYS 22 82 82 LYS LYS B . n A 1 23 GLN 23 83 83 GLN GLN B . n A 1 24 LEU 24 84 84 LEU LEU B . n A 1 25 GLN 25 85 85 GLN GLN B . n A 1 26 GLY 26 86 86 GLY GLY B . n A 1 27 SER 27 87 87 SER SER B . n A 1 28 LEU 28 88 88 LEU LEU B . n A 1 29 PRO 29 88 ? ? ? B A n A 1 30 VAL 30 88 ? ? ? B B n A 1 31 THR 31 88 ? ? ? B C n A 1 32 SER 32 88 ? ? ? B D n A 1 33 LEU 33 88 ? ? ? B E n A 1 34 ARG 34 88 ? ? ? B F n A 1 35 SER 35 88 ? ? ? B G n A 1 36 LEU 36 92 92 LEU LEU B . n A 1 37 LYS 37 93 93 LYS LYS B . n A 1 38 SER 38 94 94 SER SER B . n A 1 39 LEU 39 95 95 LEU LEU B . n A 1 40 THR 40 96 96 THR THR B . n A 1 41 SER 41 97 97 SER SER B . n A 1 42 LEU 42 98 98 LEU LEU B . n A 1 43 THR 43 99 99 THR THR B . n A 1 44 LEU 44 100 100 LEU LEU B . n A 1 45 SER 45 101 101 SER SER B . n A 1 46 SER 46 102 102 SER SER B . n A 1 47 LEU 47 103 103 LEU LEU B . n A 1 48 GLN 48 104 104 GLN GLN B . n A 1 49 LEU 49 105 105 LEU LEU B . n A 1 50 THR 50 106 106 THR THR B . n A 1 51 GLY 51 107 107 GLY GLY B . n A 1 52 VAL 52 108 108 VAL VAL B . n A 1 53 ILE 53 109 109 ILE ILE B . n A 1 54 PRO 54 110 110 PRO PRO B . n A 1 55 LYS 55 111 111 LYS LYS B . n A 1 56 GLU 56 112 112 GLU GLU B . n A 1 57 ILE 57 113 113 ILE ILE B . n A 1 58 GLY 58 114 114 GLY GLY B . n A 1 59 ASP 59 115 115 ASP ASP B . n A 1 60 PHE 60 116 116 PHE PHE B . n A 1 61 THR 61 117 117 THR THR B . n A 1 62 GLU 62 118 118 GLU GLU B . n A 1 63 LEU 63 119 119 LEU LEU B . n A 1 64 GLU 64 120 120 GLU GLU B . n A 1 65 LEU 65 121 121 LEU LEU B . n A 1 66 LEU 66 122 122 LEU LEU B . n A 1 67 ASP 67 123 123 ASP ASP B . n A 1 68 LEU 68 124 124 LEU LEU B . n A 1 69 SER 69 125 125 SER SER B . n A 1 70 ASP 70 126 126 ASP ASP B . n A 1 71 ASN 71 127 127 ASN ASN B . n A 1 72 SER 72 128 128 SER SER B . n A 1 73 LEU 73 129 129 LEU LEU B . n A 1 74 SER 74 130 130 SER SER B . n A 1 75 GLY 75 131 131 GLY GLY B . n A 1 76 ASP 76 132 132 ASP ASP B . n A 1 77 ILE 77 133 133 ILE ILE B . n A 1 78 PRO 78 134 134 PRO PRO B . n A 1 79 VAL 79 135 135 VAL VAL B . n A 1 80 GLU 80 136 136 GLU GLU B . n A 1 81 ILE 81 137 137 ILE ILE B . n A 1 82 PHE 82 138 138 PHE PHE B . n A 1 83 ARG 83 139 139 ARG ARG B . n A 1 84 LEU 84 140 140 LEU LEU B . n A 1 85 LYS 85 141 141 LYS LYS B . n A 1 86 LYS 86 142 142 LYS LYS B . n A 1 87 LEU 87 143 143 LEU LEU B . n A 1 88 LYS 88 144 144 LYS LYS B . n A 1 89 THR 89 145 145 THR THR B . n A 1 90 LEU 90 146 146 LEU LEU B . n A 1 91 SER 91 147 147 SER SER B . n A 1 92 LEU 92 148 148 LEU LEU B . n A 1 93 ASN 93 149 149 ASN ASN B . n A 1 94 THR 94 150 150 THR THR B . n A 1 95 ASN 95 151 151 ASN ASN B . n A 1 96 ASN 96 152 152 ASN ASN B . n A 1 97 LEU 97 153 153 LEU LEU B . n A 1 98 GLU 98 154 154 GLU GLU B . n A 1 99 GLY 99 155 155 GLY GLY B . n A 1 100 HIS 100 156 156 HIS HIS B . n A 1 101 ILE 101 157 157 ILE ILE B . n A 1 102 PRO 102 158 158 PRO PRO B . n A 1 103 MET 103 159 159 MET MET B . n A 1 104 GLU 104 160 160 GLU GLU B . n A 1 105 ILE 105 161 161 ILE ILE B . n A 1 106 GLY 106 162 162 GLY GLY B . n A 1 107 ASN 107 163 163 ASN ASN B . n A 1 108 LEU 108 164 164 LEU LEU B . n A 1 109 SER 109 165 165 SER SER B . n A 1 110 GLY 110 166 166 GLY GLY B . n A 1 111 LEU 111 167 167 LEU LEU B . n A 1 112 VAL 112 168 168 VAL VAL B . n A 1 113 GLU 113 169 169 GLU GLU B . n A 1 114 LEU 114 170 170 LEU LEU B . n A 1 115 MET 115 171 171 MET MET B . n A 1 116 LEU 116 172 172 LEU LEU B . n A 1 117 PHE 117 173 173 PHE PHE B . n A 1 118 ASP 118 174 174 ASP ASP B . n A 1 119 ASN 119 175 175 ASN ASN B . n A 1 120 LYS 120 176 176 LYS LYS B . n A 1 121 LEU 121 177 177 LEU LEU B . n A 1 122 SER 122 178 178 SER SER B . n A 1 123 GLY 123 179 179 GLY GLY B . n A 1 124 GLU 124 180 180 GLU GLU B . n A 1 125 ILE 125 181 181 ILE ILE B . n A 1 126 PRO 126 182 182 PRO PRO B . n A 1 127 ARG 127 183 183 ARG ARG B . n A 1 128 SER 128 184 184 SER SER B . n A 1 129 ILE 129 185 185 ILE ILE B . n A 1 130 GLY 130 186 186 GLY GLY B . n A 1 131 GLU 131 187 187 GLU GLU B . n A 1 132 LEU 132 188 188 LEU LEU B . n A 1 133 LYS 133 189 189 LYS LYS B . n A 1 134 ASN 134 190 190 ASN ASN B . n A 1 135 LEU 135 191 191 LEU LEU B . n A 1 136 GLN 136 192 192 GLN GLN B . n A 1 137 VAL 137 193 193 VAL VAL B . n A 1 138 LEU 138 194 194 LEU LEU B . n A 1 139 ARG 139 195 195 ARG ARG B . n A 1 140 ALA 140 196 196 ALA ALA B . n A 1 141 GLY 141 197 197 GLY GLY B . n A 1 142 GLY 142 198 198 GLY GLY B . n A 1 143 ASN 143 199 199 ASN ASN B . n A 1 144 LYS 144 200 200 LYS LYS B . n A 1 145 ASN 145 201 201 ASN ASN B . n A 1 146 LEU 146 202 202 LEU LEU B . n A 1 147 ARG 147 203 203 ARG ARG B . n A 1 148 GLY 148 204 204 GLY GLY B . n A 1 149 GLU 149 205 205 GLU GLU B . n A 1 150 LEU 150 206 206 LEU LEU B . n A 1 151 PRO 151 207 207 PRO PRO B . n A 1 152 TRP 152 208 208 TRP TRP B . n A 1 153 GLU 153 209 209 GLU GLU B . n A 1 154 ILE 154 210 210 ILE ILE B . n A 1 155 GLY 155 211 211 GLY GLY B . n A 1 156 ASN 156 212 212 ASN ASN B . n A 1 157 CYS 157 213 213 CYS CYS B . n A 1 158 GLU 158 214 214 GLU GLU B . n A 1 159 ASN 159 215 215 ASN ASN B . n A 1 160 LEU 160 216 216 LEU LEU B . n A 1 161 VAL 161 217 217 VAL VAL B . n A 1 162 MET 162 218 218 MET MET B . n A 1 163 LEU 163 219 219 LEU LEU B . n A 1 164 GLY 164 220 220 GLY GLY B . n A 1 165 LEU 165 221 221 LEU LEU B . n A 1 166 ALA 166 222 222 ALA ALA B . n A 1 167 GLU 167 223 223 GLU GLU B . n A 1 168 THR 168 224 224 THR THR B . n A 1 169 SER 169 225 225 SER SER B . n A 1 170 LEU 170 226 226 LEU LEU B . n A 1 171 SER 171 227 227 SER SER B . n A 1 172 GLY 172 228 228 GLY GLY B . n A 1 173 LYS 173 229 229 LYS LYS B . n A 1 174 LEU 174 230 230 LEU LEU B . n A 1 175 PRO 175 231 231 PRO PRO B . n A 1 176 ALA 176 232 232 ALA ALA B . n A 1 177 SER 177 233 233 SER SER B . n A 1 178 ILE 178 234 234 ILE ILE B . n A 1 179 GLY 179 235 235 GLY GLY B . n A 1 180 ASN 180 236 236 ASN ASN B . n A 1 181 LEU 181 237 237 LEU LEU B . n A 1 182 LYS 182 238 238 LYS LYS B . n A 1 183 ARG 183 239 239 ARG ARG B . n A 1 184 VAL 184 240 240 VAL VAL B . n A 1 185 GLN 185 241 241 GLN GLN B . n A 1 186 THR 186 242 242 THR THR B . n A 1 187 ILE 187 243 243 ILE ILE B . n A 1 188 ALA 188 244 244 ALA ALA B . n A 1 189 ILE 189 245 245 ILE ILE B . n A 1 190 TYR 190 246 246 TYR TYR B . n A 1 191 THR 191 247 247 THR THR B . n A 1 192 SER 192 248 248 SER SER B . n A 1 193 LEU 193 249 249 LEU LEU B . n A 1 194 LEU 194 250 250 LEU LEU B . n A 1 195 SER 195 251 251 SER SER B . n A 1 196 GLY 196 252 252 GLY GLY B . n A 1 197 PRO 197 253 253 PRO PRO B . n A 1 198 ILE 198 254 254 ILE ILE B . n A 1 199 PRO 199 255 255 PRO PRO B . n A 1 200 ASP 200 256 256 ASP ASP B . n A 1 201 GLU 201 257 257 GLU GLU B . n A 1 202 ILE 202 258 258 ILE ILE B . n A 1 203 GLY 203 259 259 GLY GLY B . n A 1 204 TYR 204 260 260 TYR TYR B . n A 1 205 CYS 205 261 261 CYS CYS B . n A 1 206 THR 206 262 262 THR THR B . n A 1 207 GLU 207 263 263 GLU GLU B . n A 1 208 LEU 208 264 264 LEU LEU B . n A 1 209 GLN 209 265 265 GLN GLN B . n A 1 210 ASN 210 266 266 ASN ASN B . n A 1 211 LEU 211 267 267 LEU LEU B . n A 1 212 TYR 212 268 268 TYR TYR B . n A 1 213 LEU 213 269 269 LEU LEU B . n A 1 214 TYR 214 270 270 TYR TYR B . n A 1 215 GLN 215 271 271 GLN GLN B . n A 1 216 ASN 216 272 272 ASN ASN B . n A 1 217 SER 217 273 273 SER SER B . n A 1 218 ILE 218 274 274 ILE ILE B . n A 1 219 SER 219 275 275 SER SER B . n A 1 220 GLY 220 276 276 GLY GLY B . n A 1 221 SER 221 277 277 SER SER B . n A 1 222 ILE 222 278 278 ILE ILE B . n A 1 223 PRO 223 279 279 PRO PRO B . n A 1 224 THR 224 280 280 THR THR B . n A 1 225 THR 225 281 281 THR THR B . n A 1 226 ILE 226 282 282 ILE ILE B . n A 1 227 GLY 227 283 283 GLY GLY B . n A 1 228 GLY 228 284 284 GLY GLY B . n A 1 229 LEU 229 285 285 LEU LEU B . n A 1 230 LYS 230 286 286 LYS LYS B . n A 1 231 LYS 231 287 287 LYS LYS B . n A 1 232 LEU 232 288 288 LEU LEU B . n A 1 233 GLN 233 289 289 GLN GLN B . n A 1 234 SER 234 290 290 SER SER B . n A 1 235 LEU 235 291 291 LEU LEU B . n A 1 236 LEU 236 292 292 LEU LEU B . n A 1 237 LEU 237 293 293 LEU LEU B . n A 1 238 TRP 238 294 294 TRP TRP B . n A 1 239 GLN 239 295 295 GLN GLN B . n A 1 240 ASN 240 296 296 ASN ASN B . n A 1 241 ASN 241 297 297 ASN ASN B . n A 1 242 LEU 242 298 298 LEU LEU B . n A 1 243 VAL 243 299 299 VAL VAL B . n A 1 244 GLY 244 300 300 GLY GLY B . n A 1 245 LYS 245 301 301 LYS LYS B . n A 1 246 ILE 246 302 302 ILE ILE B . n A 1 247 PRO 247 303 303 PRO PRO B . n A 1 248 THR 248 304 304 THR THR B . n A 1 249 GLU 249 305 305 GLU GLU B . n A 1 250 LEU 250 306 306 LEU LEU B . n A 1 251 GLY 251 307 307 GLY GLY B . n A 1 252 ASN 252 308 308 ASN ASN B . n A 1 253 CYS 253 309 309 CYS CYS B . n A 1 254 PRO 254 310 310 PRO PRO B . n A 1 255 GLU 255 311 311 GLU GLU B . n A 1 256 LEU 256 312 312 LEU LEU B . n A 1 257 TRP 257 313 313 TRP TRP B . n A 1 258 LEU 258 314 314 LEU LEU B . n A 1 259 ILE 259 315 315 ILE ILE B . n A 1 260 ASP 260 316 316 ASP ASP B . n A 1 261 PHE 261 317 317 PHE PHE B . n A 1 262 SER 262 318 318 SER SER B . n A 1 263 GLU 263 319 319 GLU GLU B . n A 1 264 ASN 264 320 320 ASN ASN B . n A 1 265 LEU 265 321 321 LEU LEU B . n A 1 266 LEU 266 322 322 LEU LEU B . n A 1 267 THR 267 323 323 THR THR B . n A 1 268 GLY 268 324 324 GLY GLY B . n A 1 269 THR 269 325 325 THR THR B . n A 1 270 ILE 270 326 326 ILE ILE B . n A 1 271 PRO 271 327 327 PRO PRO B . n A 1 272 ARG 272 328 328 ARG ARG B . n A 1 273 SER 273 329 329 SER SER B . n A 1 274 PHE 274 330 330 PHE PHE B . n A 1 275 GLY 275 331 331 GLY GLY B . n A 1 276 LYS 276 332 332 LYS LYS B . n A 1 277 LEU 277 333 333 LEU LEU B . n A 1 278 GLU 278 334 334 GLU GLU B . n A 1 279 ASN 279 335 335 ASN ASN B . n A 1 280 LEU 280 336 336 LEU LEU B . n A 1 281 GLN 281 337 337 GLN GLN B . n A 1 282 GLU 282 338 338 GLU GLU B . n A 1 283 LEU 283 339 339 LEU LEU B . n A 1 284 GLN 284 340 340 GLN GLN B . n A 1 285 LEU 285 341 341 LEU LEU B . n A 1 286 SER 286 342 342 SER SER B . n A 1 287 VAL 287 343 343 VAL VAL B . n A 1 288 ASN 288 344 344 ASN ASN B . n A 1 289 GLN 289 345 345 GLN GLN B . n A 1 290 ILE 290 346 346 ILE ILE B . n A 1 291 SER 291 347 347 SER SER B . n A 1 292 GLY 292 348 348 GLY GLY B . n A 1 293 THR 293 349 349 THR THR B . n A 1 294 ILE 294 350 350 ILE ILE B . n A 1 295 PRO 295 351 351 PRO PRO B . n A 1 296 GLU 296 352 352 GLU GLU B . n A 1 297 GLU 297 353 353 GLU GLU B . n A 1 298 LEU 298 354 354 LEU LEU B . n A 1 299 THR 299 355 355 THR THR B . n A 1 300 ASN 300 356 356 ASN ASN B . n A 1 301 CYS 301 357 357 CYS CYS B . n A 1 302 THR 302 358 358 THR THR B . n A 1 303 LYS 303 359 359 LYS LYS B . n A 1 304 LEU 304 360 360 LEU LEU B . n A 1 305 THR 305 361 361 THR THR B . n A 1 306 HIS 306 362 362 HIS HIS B . n A 1 307 LEU 307 363 363 LEU LEU B . n A 1 308 GLU 308 364 364 GLU GLU B . n A 1 309 ILE 309 365 365 ILE ILE B . n A 1 310 ASP 310 366 366 ASP ASP B . n A 1 311 ASN 311 367 367 ASN ASN B . n A 1 312 ASN 312 368 368 ASN ASN B . n A 1 313 LEU 313 369 369 LEU LEU B . n A 1 314 ILE 314 370 370 ILE ILE B . n A 1 315 THR 315 371 371 THR THR B . n A 1 316 GLY 316 372 372 GLY GLY B . n A 1 317 GLU 317 373 373 GLU GLU B . n A 1 318 ILE 318 374 374 ILE ILE B . n A 1 319 PRO 319 375 375 PRO PRO B . n A 1 320 SER 320 376 376 SER SER B . n A 1 321 LEU 321 377 377 LEU LEU B . n A 1 322 MET 322 378 378 MET MET B . n A 1 323 SER 323 379 379 SER SER B . n A 1 324 ASN 324 380 380 ASN ASN B . n A 1 325 LEU 325 381 381 LEU LEU B . n A 1 326 ARG 326 382 382 ARG ARG B . n A 1 327 SER 327 383 383 SER SER B . n A 1 328 LEU 328 384 384 LEU LEU B . n A 1 329 THR 329 385 385 THR THR B . n A 1 330 MET 330 386 386 MET MET B . n A 1 331 PHE 331 387 387 PHE PHE B . n A 1 332 PHE 332 388 388 PHE PHE B . n A 1 333 ALA 333 389 389 ALA ALA B . n A 1 334 TRP 334 390 390 TRP TRP B . n A 1 335 GLN 335 391 391 GLN GLN B . n A 1 336 ASN 336 392 392 ASN ASN B . n A 1 337 LYS 337 393 393 LYS LYS B . n A 1 338 LEU 338 394 394 LEU LEU B . n A 1 339 THR 339 395 395 THR THR B . n A 1 340 GLY 340 396 396 GLY GLY B . n A 1 341 ASN 341 397 397 ASN ASN B . n A 1 342 ILE 342 398 398 ILE ILE B . n A 1 343 PRO 343 399 399 PRO PRO B . n A 1 344 GLN 344 400 400 GLN GLN B . n A 1 345 SER 345 401 401 SER SER B . n A 1 346 LEU 346 402 402 LEU LEU B . n A 1 347 SER 347 403 403 SER SER B . n A 1 348 GLN 348 404 404 GLN GLN B . n A 1 349 CYS 349 405 405 CYS CYS B . n A 1 350 ARG 350 406 406 ARG ARG B . n A 1 351 GLU 351 407 407 GLU GLU B . n A 1 352 LEU 352 408 408 LEU LEU B . n A 1 353 GLN 353 409 409 GLN GLN B . n A 1 354 ALA 354 410 410 ALA ALA B . n A 1 355 ILE 355 411 411 ILE ILE B . n A 1 356 ASP 356 412 412 ASP ASP B . n A 1 357 LEU 357 413 413 LEU LEU B . n A 1 358 SER 358 414 414 SER SER B . n A 1 359 TYR 359 415 415 TYR TYR B . n A 1 360 ASN 360 416 416 ASN ASN B . n A 1 361 SER 361 417 417 SER SER B . n A 1 362 LEU 362 418 418 LEU LEU B . n A 1 363 SER 363 419 419 SER SER B . n A 1 364 GLY 364 420 420 GLY GLY B . n A 1 365 SER 365 421 421 SER SER B . n A 1 366 ILE 366 422 422 ILE ILE B . n A 1 367 PRO 367 423 423 PRO PRO B . n A 1 368 LYS 368 424 424 LYS LYS B . n A 1 369 GLU 369 425 425 GLU GLU B . n A 1 370 ILE 370 426 426 ILE ILE B . n A 1 371 PHE 371 427 427 PHE PHE B . n A 1 372 GLY 372 428 428 GLY GLY B . n A 1 373 LEU 373 429 429 LEU LEU B . n A 1 374 ARG 374 430 430 ARG ARG B . n A 1 375 ASN 375 431 431 ASN ASN B . n A 1 376 LEU 376 432 432 LEU LEU B . n A 1 377 THR 377 433 433 THR THR B . n A 1 378 LYS 378 434 434 LYS LYS B . n A 1 379 LEU 379 435 435 LEU LEU B . n A 1 380 LEU 380 436 436 LEU LEU B . n A 1 381 LEU 381 437 437 LEU LEU B . n A 1 382 LEU 382 438 438 LEU LEU B . n A 1 383 SER 383 439 439 SER SER B . n A 1 384 ASN 384 440 440 ASN ASN B . n A 1 385 ASP 385 441 441 ASP ASP B . n A 1 386 LEU 386 442 442 LEU LEU B . n A 1 387 SER 387 443 443 SER SER B . n A 1 388 GLY 388 444 444 GLY GLY B . n A 1 389 PHE 389 445 445 PHE PHE B . n A 1 390 ILE 390 446 446 ILE ILE B . n A 1 391 PRO 391 447 447 PRO PRO B . n A 1 392 PRO 392 448 448 PRO PRO B . n A 1 393 ASP 393 449 449 ASP ASP B . n A 1 394 ILE 394 450 450 ILE ILE B . n A 1 395 GLY 395 451 451 GLY GLY B . n A 1 396 ASN 396 452 452 ASN ASN B . n A 1 397 CYS 397 453 453 CYS CYS B . n A 1 398 THR 398 454 454 THR THR B . n A 1 399 ASN 399 455 455 ASN ASN B . n A 1 400 LEU 400 456 456 LEU LEU B . n A 1 401 TYR 401 457 457 TYR TYR B . n A 1 402 ARG 402 458 458 ARG ARG B . n A 1 403 LEU 403 459 459 LEU LEU B . n A 1 404 ARG 404 460 460 ARG ARG B . n A 1 405 LEU 405 461 461 LEU LEU B . n A 1 406 ASN 406 462 462 ASN ASN B . n A 1 407 GLY 407 463 463 GLY GLY B . n A 1 408 ASN 408 464 464 ASN ASN B . n A 1 409 ARG 409 465 465 ARG ARG B . n A 1 410 LEU 410 466 466 LEU LEU B . n A 1 411 ALA 411 467 467 ALA ALA B . n A 1 412 GLY 412 468 468 GLY GLY B . n A 1 413 SER 413 469 469 SER SER B . n A 1 414 ILE 414 470 470 ILE ILE B . n A 1 415 PRO 415 471 471 PRO PRO B . n A 1 416 SER 416 472 472 SER SER B . n A 1 417 GLU 417 473 473 GLU GLU B . n A 1 418 ILE 418 474 474 ILE ILE B . n A 1 419 GLY 419 475 475 GLY GLY B . n A 1 420 ASN 420 476 476 ASN ASN B . n A 1 421 LEU 421 477 477 LEU LEU B . n A 1 422 LYS 422 478 478 LYS LYS B . n A 1 423 ASN 423 479 479 ASN ASN B . n A 1 424 LEU 424 480 480 LEU LEU B . n A 1 425 ASN 425 481 481 ASN ASN B . n A 1 426 PHE 426 482 482 PHE PHE B . n A 1 427 VAL 427 483 483 VAL VAL B . n A 1 428 ASP 428 484 484 ASP ASP B . n A 1 429 ILE 429 485 485 ILE ILE B . n A 1 430 SER 430 486 486 SER SER B . n A 1 431 GLU 431 487 487 GLU GLU B . n A 1 432 ASN 432 488 488 ASN ASN B . n A 1 433 ARG 433 489 489 ARG ARG B . n A 1 434 LEU 434 490 490 LEU LEU B . n A 1 435 VAL 435 491 491 VAL VAL B . n A 1 436 GLY 436 492 492 GLY GLY B . n A 1 437 SER 437 493 493 SER SER B . n A 1 438 ILE 438 494 494 ILE ILE B . n A 1 439 PRO 439 495 495 PRO PRO B . n A 1 440 PRO 440 496 496 PRO PRO B . n A 1 441 ALA 441 497 497 ALA ALA B . n A 1 442 ILE 442 498 498 ILE ILE B . n A 1 443 SER 443 499 499 SER SER B . n A 1 444 GLY 444 500 500 GLY GLY B . n A 1 445 CYS 445 501 501 CYS CYS B . n A 1 446 GLU 446 502 502 GLU GLU B . n A 1 447 SER 447 503 503 SER SER B . n A 1 448 LEU 448 504 504 LEU LEU B . n A 1 449 GLU 449 505 505 GLU GLU B . n A 1 450 PHE 450 506 506 PHE PHE B . n A 1 451 LEU 451 507 507 LEU LEU B . n A 1 452 ASP 452 508 508 ASP ASP B . n A 1 453 LEU 453 509 509 LEU LEU B . n A 1 454 HIS 454 510 510 HIS HIS B . n A 1 455 THR 455 511 511 THR THR B . n A 1 456 ASN 456 512 512 ASN ASN B . n A 1 457 SER 457 513 513 SER SER B . n A 1 458 LEU 458 514 514 LEU LEU B . n A 1 459 SER 459 515 515 SER SER B . n A 1 460 GLY 460 516 516 GLY GLY B . n A 1 461 SER 461 517 517 SER SER B . n A 1 462 LEU 462 518 518 LEU LEU B . n A 1 463 LEU 463 519 519 LEU LEU B . n A 1 464 GLY 464 520 520 GLY GLY B . n A 1 465 THR 465 521 521 THR THR B . n A 1 466 THR 466 522 522 THR THR B . n A 1 467 LEU 467 523 523 LEU LEU B . n A 1 468 PRO 468 524 524 PRO PRO B . n A 1 469 LYS 469 525 525 LYS LYS B . n A 1 470 SER 470 526 526 SER SER B . n A 1 471 LEU 471 527 527 LEU LEU B . n A 1 472 LYS 472 528 528 LYS LYS B . n A 1 473 PHE 473 529 529 PHE PHE B . n A 1 474 ILE 474 530 530 ILE ILE B . n A 1 475 ASP 475 531 531 ASP ASP B . n A 1 476 PHE 476 532 532 PHE PHE B . n A 1 477 SER 477 533 533 SER SER B . n A 1 478 ASP 478 534 534 ASP ASP B . n A 1 479 ASN 479 535 535 ASN ASN B . n A 1 480 ALA 480 536 536 ALA ALA B . n A 1 481 LEU 481 537 537 LEU LEU B . n A 1 482 SER 482 538 538 SER SER B . n A 1 483 SER 483 539 539 SER SER B . n A 1 484 THR 484 540 540 THR THR B . n A 1 485 LEU 485 541 541 LEU LEU B . n A 1 486 PRO 486 542 542 PRO PRO B . n A 1 487 PRO 487 543 543 PRO PRO B . n A 1 488 GLY 488 544 544 GLY GLY B . n A 1 489 ILE 489 545 545 ILE ILE B . n A 1 490 GLY 490 546 546 GLY GLY B . n A 1 491 LEU 491 547 547 LEU LEU B . n A 1 492 LEU 492 548 548 LEU LEU B . n A 1 493 THR 493 549 549 THR THR B . n A 1 494 GLU 494 550 550 GLU GLU B . n A 1 495 LEU 495 551 551 LEU LEU B . n A 1 496 THR 496 552 552 THR THR B . n A 1 497 LYS 497 553 553 LYS LYS B . n A 1 498 LEU 498 554 554 LEU LEU B . n A 1 499 ASN 499 555 555 ASN ASN B . n A 1 500 LEU 500 556 556 LEU LEU B . n A 1 501 ALA 501 557 557 ALA ALA B . n A 1 502 LYS 502 558 558 LYS LYS B . n A 1 503 ASN 503 559 559 ASN ASN B . n A 1 504 ARG 504 560 560 ARG ARG B . n A 1 505 LEU 505 561 561 LEU LEU B . n A 1 506 SER 506 562 562 SER SER B . n A 1 507 GLY 507 563 563 GLY GLY B . n A 1 508 GLU 508 564 564 GLU GLU B . n A 1 509 ILE 509 565 565 ILE ILE B . n A 1 510 PRO 510 566 566 PRO PRO B . n A 1 511 ARG 511 567 567 ARG ARG B . n A 1 512 GLU 512 568 568 GLU GLU B . n A 1 513 ILE 513 569 569 ILE ILE B . n A 1 514 SER 514 570 570 SER SER B . n A 1 515 THR 515 571 571 THR THR B . n A 1 516 CYS 516 572 572 CYS CYS B . n A 1 517 ARG 517 573 573 ARG ARG B . n A 1 518 SER 518 574 574 SER SER B . n A 1 519 LEU 519 575 575 LEU LEU B . n A 1 520 GLN 520 576 576 GLN GLN B . n A 1 521 LEU 521 577 577 LEU LEU B . n A 1 522 LEU 522 578 578 LEU LEU B . n A 1 523 ASN 523 579 579 ASN ASN B . n A 1 524 LEU 524 580 580 LEU LEU B . n A 1 525 GLY 525 581 581 GLY GLY B . n A 1 526 GLU 526 582 582 GLU GLU B . n A 1 527 ASN 527 583 583 ASN ASN B . n A 1 528 ASP 528 584 584 ASP ASP B . n A 1 529 PHE 529 585 585 PHE PHE B . n A 1 530 SER 530 586 586 SER SER B . n A 1 531 GLY 531 587 587 GLY GLY B . n A 1 532 GLU 532 588 588 GLU GLU B . n A 1 533 ILE 533 589 589 ILE ILE B . n A 1 534 PRO 534 590 590 PRO PRO B . n A 1 535 ASP 535 591 591 ASP ASP B . n A 1 536 GLU 536 592 592 GLU GLU B . n A 1 537 LEU 537 593 593 LEU LEU B . n A 1 538 GLY 538 594 594 GLY GLY B . n A 1 539 GLN 539 595 595 GLN GLN B . n A 1 540 ILE 540 596 596 ILE ILE B . n A 1 541 PRO 541 597 597 PRO PRO B . n A 1 542 SER 542 598 598 SER SER B . n A 1 543 LEU 543 599 599 LEU LEU B . n A 1 544 ALA 544 600 600 ALA ALA B . n A 1 545 ILE 545 601 601 ILE ILE B . n A 1 546 SER 546 602 602 SER SER B . n A 1 547 LEU 547 603 603 LEU LEU B . n A 1 548 ASN 548 604 604 ASN ASN B . n A 1 549 LEU 549 605 605 LEU LEU B . n A 1 550 SER 550 606 606 SER SER B . n A 1 551 CYS 551 607 607 CYS CYS B . n A 1 552 ASN 552 608 608 ASN ASN B . n A 1 553 ARG 553 609 609 ARG ARG B . n A 1 554 PHE 554 610 610 PHE PHE B . n A 1 555 VAL 555 611 611 VAL VAL B . n A 1 556 GLY 556 612 612 GLY GLY B . n A 1 557 GLU 557 613 613 GLU GLU B . n A 1 558 ILE 558 614 614 ILE ILE B . n A 1 559 PRO 559 615 615 PRO PRO B . n A 1 560 SER 560 616 616 SER SER B . n A 1 561 ARG 561 617 617 ARG ARG B . n A 1 562 PHE 562 618 618 PHE PHE B . n A 1 563 SER 563 619 619 SER SER B . n A 1 564 ASP 564 620 620 ASP ASP B . n A 1 565 LEU 565 621 621 LEU LEU B . n A 1 566 LYS 566 622 622 LYS LYS B . n A 1 567 ASN 567 623 623 ASN ASN B . n A 1 568 LEU 568 624 624 LEU LEU B . n A 1 569 GLY 569 625 625 GLY GLY B . n A 1 570 VAL 570 626 626 VAL VAL B . n A 1 571 LEU 571 627 627 LEU LEU B . n A 1 572 ASP 572 628 628 ASP ASP B . n A 1 573 VAL 573 629 629 VAL VAL B . n A 1 574 SER 574 630 630 SER SER B . n A 1 575 HIS 575 631 631 HIS HIS B . n A 1 576 ASN 576 632 632 ASN ASN B . n A 1 577 GLN 577 633 633 GLN GLN B . n A 1 578 LEU 578 634 634 LEU LEU B . n A 1 579 THR 579 635 635 THR THR B . n A 1 580 GLY 580 636 636 GLY GLY B . n A 1 581 ASN 581 637 637 ASN ASN B . n A 1 582 LEU 582 638 638 LEU LEU B . n A 1 583 ASN 583 639 639 ASN ASN B . n A 1 584 VAL 584 640 640 VAL VAL B . n A 1 585 LEU 585 641 641 LEU LEU B . n A 1 586 THR 586 642 642 THR THR B . n A 1 587 ASP 587 643 643 ASP ASP B . n A 1 588 LEU 588 644 644 LEU LEU B . n A 1 589 GLN 589 645 645 GLN GLN B . n A 1 590 ASN 590 646 646 ASN ASN B . n A 1 591 LEU 591 647 647 LEU LEU B . n A 1 592 VAL 592 648 648 VAL VAL B . n A 1 593 SER 593 649 649 SER SER B . n A 1 594 LEU 594 650 650 LEU LEU B . n A 1 595 ASN 595 651 651 ASN ASN B . n A 1 596 ILE 596 652 652 ILE ILE B . n A 1 597 SER 597 653 653 SER SER B . n A 1 598 TYR 598 654 654 TYR TYR B . n A 1 599 ASN 599 655 655 ASN ASN B . n A 1 600 ASP 600 656 656 ASP ASP B . n A 1 601 PHE 601 657 657 PHE PHE B . n A 1 602 SER 602 658 658 SER SER B . n A 1 603 GLY 603 659 659 GLY GLY B . n A 1 604 ASP 604 660 660 ASP ASP B . n A 1 605 LEU 605 661 661 LEU LEU B . n A 1 606 PRO 606 662 662 PRO PRO B . n A 1 607 ASN 607 663 663 ASN ASN B . n A 1 608 THR 608 664 664 THR THR B . n A 1 609 PRO 609 665 665 PRO PRO B . n A 1 610 PHE 610 666 666 PHE PHE B . n A 1 611 PHE 611 667 667 PHE PHE B . n A 1 612 ARG 612 668 668 ARG ARG B . n A 1 613 ARG 613 669 669 ARG ARG B . n A 1 614 LEU 614 670 670 LEU LEU B . n A 1 615 PRO 615 671 671 PRO PRO B . n A 1 616 LEU 616 672 672 LEU LEU B . n A 1 617 SER 617 673 673 SER SER B . n A 1 618 ASP 618 674 674 ASP ASP B . n A 1 619 LEU 619 675 675 LEU LEU B . n A 1 620 ALA 620 676 676 ALA ALA B . n A 1 621 SER 621 677 677 SER SER B . n A 1 622 ASN 622 678 678 ASN ASN B . n A 1 623 ARG 623 679 679 ARG ARG B . n A 1 624 GLY 624 680 680 GLY GLY B . n A 1 625 LEU 625 681 681 LEU LEU B . n A 1 626 TYR 626 682 682 TYR TYR B . n A 1 627 ILE 627 683 683 ILE ILE B . n A 1 628 SER 628 684 684 SER SER B . n A 1 629 ASN 629 685 685 ASN ASN B . n A 1 630 ALA 630 686 686 ALA ALA B . n A 1 631 ILE 631 687 687 ILE ILE B . n A 1 632 SER 632 688 688 SER SER B . n A 1 633 THR 633 689 ? ? ? B . n B 2 1 ASP 1 44 44 ASP ASP A . n B 2 2 PTR 2 45 45 PTR PTR A . n B 2 3 PRO 3 46 46 PRO PRO A . n B 2 4 LYS 4 47 47 LYS LYS A . n B 2 5 PRO 5 48 48 PRO PRO A . n B 2 6 SER 6 49 49 SER SER A . n B 2 7 THR 7 50 50 THR THR A . n B 2 8 ARG 8 51 51 ARG ARG A . n B 2 9 PRO 9 52 52 PRO PRO A . n B 2 10 HZP 10 53 53 HZP HYP A . n B 2 11 ARG 11 54 54 ARG ARG A . n B 2 12 HIS 12 55 55 HIS HIS A . n B 2 13 ASN 13 56 56 ASN ASN A . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code C 3 NAG 1 701 4521 NAG NAG B . D 3 NAG 2 702 4522 NAG NAG B . E 3 NAG 1 703 6041 NAG NAG B . F 3 NAG 1 704 6501 NAG NAG B . # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_and_software_defined_assembly _pdbx_struct_assembly.method_details PISA _pdbx_struct_assembly.oligomeric_details dimeric _pdbx_struct_assembly.oligomeric_count 2 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 1 'ABSA (A^2)' 3010 ? 1 MORE 7 ? 1 'SSA (A^2)' 26690 ? # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # _pdbx_audit_revision_history.ordinal 1 _pdbx_audit_revision_history.data_content_type 'Structure model' _pdbx_audit_revision_history.major_revision 1 _pdbx_audit_revision_history.minor_revision 0 _pdbx_audit_revision_history.revision_date 2017-03-22 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _software.citation_id _software.classification _software.compiler_name _software.compiler_version _software.contact_author _software.contact_author_email _software.date _software.description _software.dependencies _software.hardware _software.language _software.location _software.mods _software.name _software.os _software.os_version _software.type _software.version _software.pdbx_ordinal ? refinement ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? . 1 ? 'data scaling' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? . 2 ? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? 3.20 3 ? 'data scaling' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? . 4 ? phasing ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 'phenix.refine: 1.8_1069' 5 ? refinement ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? . 6 # _pdbx_validate_close_contact.id 1 _pdbx_validate_close_contact.PDB_model_num 1 _pdbx_validate_close_contact.auth_atom_id_1 O4 _pdbx_validate_close_contact.auth_asym_id_1 B _pdbx_validate_close_contact.auth_comp_id_1 NAG _pdbx_validate_close_contact.auth_seq_id_1 701 _pdbx_validate_close_contact.PDB_ins_code_1 ? _pdbx_validate_close_contact.label_alt_id_1 ? _pdbx_validate_close_contact.auth_atom_id_2 O5 _pdbx_validate_close_contact.auth_asym_id_2 B _pdbx_validate_close_contact.auth_comp_id_2 NAG _pdbx_validate_close_contact.auth_seq_id_2 702 _pdbx_validate_close_contact.PDB_ins_code_2 ? _pdbx_validate_close_contact.label_alt_id_2 ? _pdbx_validate_close_contact.dist 1.83 # _pdbx_validate_rmsd_angle.id 1 _pdbx_validate_rmsd_angle.PDB_model_num 1 _pdbx_validate_rmsd_angle.auth_atom_id_1 CA _pdbx_validate_rmsd_angle.auth_asym_id_1 B _pdbx_validate_rmsd_angle.auth_comp_id_1 LEU _pdbx_validate_rmsd_angle.auth_seq_id_1 237 _pdbx_validate_rmsd_angle.PDB_ins_code_1 ? _pdbx_validate_rmsd_angle.label_alt_id_1 ? _pdbx_validate_rmsd_angle.auth_atom_id_2 CB _pdbx_validate_rmsd_angle.auth_asym_id_2 B _pdbx_validate_rmsd_angle.auth_comp_id_2 LEU _pdbx_validate_rmsd_angle.auth_seq_id_2 237 _pdbx_validate_rmsd_angle.PDB_ins_code_2 ? _pdbx_validate_rmsd_angle.label_alt_id_2 ? _pdbx_validate_rmsd_angle.auth_atom_id_3 CG _pdbx_validate_rmsd_angle.auth_asym_id_3 B _pdbx_validate_rmsd_angle.auth_comp_id_3 LEU _pdbx_validate_rmsd_angle.auth_seq_id_3 237 _pdbx_validate_rmsd_angle.PDB_ins_code_3 ? _pdbx_validate_rmsd_angle.label_alt_id_3 ? _pdbx_validate_rmsd_angle.angle_value 129.44 _pdbx_validate_rmsd_angle.angle_target_value 115.30 _pdbx_validate_rmsd_angle.angle_deviation 14.14 _pdbx_validate_rmsd_angle.angle_standard_deviation 2.30 _pdbx_validate_rmsd_angle.linker_flag N # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 ASP B 126 ? ? 60.72 64.28 2 1 GLN B 192 ? ? -123.74 -56.21 3 1 VAL B 217 ? ? -130.67 -49.03 4 1 GLN B 289 ? ? -128.00 -57.40 5 1 GLN B 295 ? ? 56.80 72.01 6 1 VAL B 343 ? ? 60.02 74.32 7 1 THR B 358 ? ? -27.86 -37.35 8 1 SER B 439 ? ? 58.39 73.93 9 1 THR B 511 ? ? 56.19 70.30 10 1 ASP B 534 ? ? 61.35 65.68 11 1 SER B 539 ? ? 57.94 -142.89 12 1 THR B 552 ? ? -127.82 -56.77 13 1 ALA B 600 ? ? -130.30 -56.30 # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 Y 1 B CYS 61 ? SG ? A CYS 1 SG 2 1 Y 1 B ASN 62 ? CG ? A ASN 2 CG 3 1 Y 1 B ASN 62 ? OD1 ? A ASN 2 OD1 4 1 Y 1 B ASN 62 ? ND2 ? A ASN 2 ND2 5 1 Y 1 B THR 64 ? OG1 ? A THR 4 OG1 6 1 Y 1 B THR 64 ? CG2 ? A THR 4 CG2 7 1 Y 1 B GLU 81 ? CG ? A GLU 21 CG 8 1 Y 1 B GLU 81 ? CD ? A GLU 21 CD 9 1 Y 1 B GLU 81 ? OE1 ? A GLU 21 OE1 10 1 Y 1 B GLU 81 ? OE2 ? A GLU 21 OE2 11 1 Y 1 B LYS 82 ? CG ? A LYS 22 CG 12 1 Y 1 B LYS 82 ? CD ? A LYS 22 CD 13 1 Y 1 B LYS 82 ? CE ? A LYS 22 CE 14 1 Y 1 B LYS 82 ? NZ ? A LYS 22 NZ 15 1 Y 1 B GLN 83 ? CG ? A GLN 23 CG 16 1 Y 1 B GLN 83 ? CD ? A GLN 23 CD 17 1 Y 1 B GLN 83 ? OE1 ? A GLN 23 OE1 18 1 Y 1 B GLN 83 ? NE2 ? A GLN 23 NE2 19 1 Y 1 B GLN 104 ? CG ? A GLN 48 CG 20 1 Y 1 B GLN 104 ? CD ? A GLN 48 CD 21 1 Y 1 B GLN 104 ? OE1 ? A GLN 48 OE1 22 1 Y 1 B GLN 104 ? NE2 ? A GLN 48 NE2 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 B PRO 88 A A PRO 29 2 1 Y 1 B VAL 88 B A VAL 30 3 1 Y 1 B THR 88 C A THR 31 4 1 Y 1 B SER 88 D A SER 32 5 1 Y 1 B LEU 88 E A LEU 33 6 1 Y 1 B ARG 88 F A ARG 34 7 1 Y 1 B SER 88 G A SER 35 8 1 Y 1 B THR 689 ? A THR 633 # _pdbx_entity_nonpoly.entity_id 3 _pdbx_entity_nonpoly.name N-ACETYL-D-GLUCOSAMINE _pdbx_entity_nonpoly.comp_id NAG #