data_5FBH # _entry.id 5FBH # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 5FBH WWPDB D_1000216322 # _pdbx_database_related.db_name PDB _pdbx_database_related.details . _pdbx_database_related.db_id 5FBK _pdbx_database_related.content_type unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.entry_id 5FBH _pdbx_database_status.recvd_initial_deposition_date 2015-12-14 _pdbx_database_status.SG_entry N _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? _pdbx_database_status.pdb_format_compatible Y # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Zhang, T.' 1 'Zhang, C.' 2 'Miller, C.L.' 3 'Zou, J.' 4 'Moremen, K.W.' 5 'Brown, E.M.' 6 'Yang, J.J.' 7 'Hu, J.' 8 # _citation.abstract ? _citation.abstract_id_CAS ? _citation.book_id_ISBN ? _citation.book_publisher ? _citation.book_publisher_city ? _citation.book_title ? _citation.coordinate_linkage ? _citation.country US _citation.database_id_Medline ? _citation.details ? _citation.id primary _citation.journal_abbrev 'Sci Adv' _citation.journal_id_ASTM ? _citation.journal_id_CSD ? _citation.journal_id_ISSN 2375-2548 _citation.journal_full ? _citation.journal_issue ? _citation.journal_volume 2 _citation.language ? _citation.page_first e1600241 _citation.page_last e1600241 _citation.title ;Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist. ; _citation.year 2016 _citation.database_id_CSD ? _citation.pdbx_database_id_DOI 10.1126/sciadv.1600241 _citation.pdbx_database_id_PubMed 27386547 _citation.unpublished_flag ? # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Zhang, C.' 1 primary 'Zhang, T.' 2 primary 'Zou, J.' 3 primary 'Miller, C.L.' 4 primary 'Gorkhali, R.' 5 primary 'Yang, J.Y.' 6 primary 'Schilmiller, A.' 7 primary 'Wang, S.' 8 primary 'Huang, K.' 9 primary 'Brown, E.M.' 10 primary 'Moremen, K.W.' 11 primary 'Hu, J.' 12 primary 'Yang, J.J.' 13 # _cell.entry_id 5FBH _cell.length_a 172.107 _cell.length_b 83.106 _cell.length_c 94.470 _cell.angle_alpha 90.00 _cell.angle_beta 105.15 _cell.angle_gamma 90.00 _cell.Z_PDB 8 _cell.pdbx_unique_axis ? # _symmetry.entry_id 5FBH _symmetry.space_group_name_H-M 'C 1 2 1' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 5 # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'Extracellular calcium-sensing receptor' 64215.383 2 ? ? 'UNP residues 20-541' ? 2 non-polymer syn 'GADOLINIUM ION' 157.250 2 ? ? ? ? 3 non-polymer syn 'MAGNESIUM ION' 24.305 3 ? ? ? ? 4 non-polymer syn 'BICARBONATE ION' 61.017 2 ? ? ? ? 5 non-polymer syn 'CHLORIDE ION' 35.453 2 ? ? ? ? 6 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 7 ? ? ? ? 7 non-polymer syn CYCLOMETHYLTRYPTOPHAN 216.236 2 ? ? ? ? 8 water nat water 18.015 17 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name 'CaSR,Parathyroid cell calcium-sensing receptor 1,PCaR1' # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer yes _entity_poly.pdbx_seq_one_letter_code ;MRLLTALFAYFIVALILAFSVSAKSMHHHHHHHHSAWSHPQFEKEFYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKS RPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSE HIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIA ADDDYGRPGIEKFREEAEERDI(CSO)IDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNIT GKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLP VDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSC ADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDE(CSO)GDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINE EKILWSGFSREVPFSN ; _entity_poly.pdbx_seq_one_letter_code_can ;MRLLTALFAYFIVALILAFSVSAKSMHHHHHHHHSAWSHPQFEKEFYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKS RPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSE HIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIA ADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIW LASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTF LRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIK KVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGF SREVPFSN ; _entity_poly.pdbx_strand_id B,A _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 MET n 1 2 ARG n 1 3 LEU n 1 4 LEU n 1 5 THR n 1 6 ALA n 1 7 LEU n 1 8 PHE n 1 9 ALA n 1 10 TYR n 1 11 PHE n 1 12 ILE n 1 13 VAL n 1 14 ALA n 1 15 LEU n 1 16 ILE n 1 17 LEU n 1 18 ALA n 1 19 PHE n 1 20 SER n 1 21 VAL n 1 22 SER n 1 23 ALA n 1 24 LYS n 1 25 SER n 1 26 MET n 1 27 HIS n 1 28 HIS n 1 29 HIS n 1 30 HIS n 1 31 HIS n 1 32 HIS n 1 33 HIS n 1 34 HIS n 1 35 SER n 1 36 ALA n 1 37 TRP n 1 38 SER n 1 39 HIS n 1 40 PRO n 1 41 GLN n 1 42 PHE n 1 43 GLU n 1 44 LYS n 1 45 GLU n 1 46 PHE n 1 47 TYR n 1 48 GLY n 1 49 PRO n 1 50 ASP n 1 51 GLN n 1 52 ARG n 1 53 ALA n 1 54 GLN n 1 55 LYS n 1 56 LYS n 1 57 GLY n 1 58 ASP n 1 59 ILE n 1 60 ILE n 1 61 LEU n 1 62 GLY n 1 63 GLY n 1 64 LEU n 1 65 PHE n 1 66 PRO n 1 67 ILE n 1 68 HIS n 1 69 PHE n 1 70 GLY n 1 71 VAL n 1 72 ALA n 1 73 ALA n 1 74 LYS n 1 75 ASP n 1 76 GLN n 1 77 ASP n 1 78 LEU n 1 79 LYS n 1 80 SER n 1 81 ARG n 1 82 PRO n 1 83 GLU n 1 84 SER n 1 85 VAL n 1 86 GLU n 1 87 CYS n 1 88 ILE n 1 89 ARG n 1 90 TYR n 1 91 ASN n 1 92 PHE n 1 93 ARG n 1 94 GLY n 1 95 PHE n 1 96 ARG n 1 97 TRP n 1 98 LEU n 1 99 GLN n 1 100 ALA n 1 101 MET n 1 102 ILE n 1 103 PHE n 1 104 ALA n 1 105 ILE n 1 106 GLU n 1 107 GLU n 1 108 ILE n 1 109 ASN n 1 110 SER n 1 111 SER n 1 112 PRO n 1 113 ALA n 1 114 LEU n 1 115 LEU n 1 116 PRO n 1 117 ASN n 1 118 LEU n 1 119 THR n 1 120 LEU n 1 121 GLY n 1 122 TYR n 1 123 ARG n 1 124 ILE n 1 125 PHE n 1 126 ASP n 1 127 THR n 1 128 CYS n 1 129 ASN n 1 130 THR n 1 131 VAL n 1 132 SER n 1 133 LYS n 1 134 ALA n 1 135 LEU n 1 136 GLU n 1 137 ALA n 1 138 THR n 1 139 LEU n 1 140 SER n 1 141 PHE n 1 142 VAL n 1 143 ALA n 1 144 GLN n 1 145 ASN n 1 146 LYS n 1 147 ILE n 1 148 ASP n 1 149 SER n 1 150 LEU n 1 151 ASN n 1 152 LEU n 1 153 ASP n 1 154 GLU n 1 155 PHE n 1 156 CYS n 1 157 ASN n 1 158 CYS n 1 159 SER n 1 160 GLU n 1 161 HIS n 1 162 ILE n 1 163 PRO n 1 164 SER n 1 165 THR n 1 166 ILE n 1 167 ALA n 1 168 VAL n 1 169 VAL n 1 170 GLY n 1 171 ALA n 1 172 THR n 1 173 GLY n 1 174 SER n 1 175 GLY n 1 176 VAL n 1 177 SER n 1 178 THR n 1 179 ALA n 1 180 VAL n 1 181 ALA n 1 182 ASN n 1 183 LEU n 1 184 LEU n 1 185 GLY n 1 186 LEU n 1 187 PHE n 1 188 TYR n 1 189 ILE n 1 190 PRO n 1 191 GLN n 1 192 VAL n 1 193 SER n 1 194 TYR n 1 195 ALA n 1 196 SER n 1 197 SER n 1 198 SER n 1 199 ARG n 1 200 LEU n 1 201 LEU n 1 202 SER n 1 203 ASN n 1 204 LYS n 1 205 ASN n 1 206 GLN n 1 207 PHE n 1 208 LYS n 1 209 SER n 1 210 PHE n 1 211 LEU n 1 212 ARG n 1 213 THR n 1 214 ILE n 1 215 PRO n 1 216 ASN n 1 217 ASP n 1 218 GLU n 1 219 HIS n 1 220 GLN n 1 221 ALA n 1 222 THR n 1 223 ALA n 1 224 MET n 1 225 ALA n 1 226 ASP n 1 227 ILE n 1 228 ILE n 1 229 GLU n 1 230 TYR n 1 231 PHE n 1 232 ARG n 1 233 TRP n 1 234 ASN n 1 235 TRP n 1 236 VAL n 1 237 GLY n 1 238 THR n 1 239 ILE n 1 240 ALA n 1 241 ALA n 1 242 ASP n 1 243 ASP n 1 244 ASP n 1 245 TYR n 1 246 GLY n 1 247 ARG n 1 248 PRO n 1 249 GLY n 1 250 ILE n 1 251 GLU n 1 252 LYS n 1 253 PHE n 1 254 ARG n 1 255 GLU n 1 256 GLU n 1 257 ALA n 1 258 GLU n 1 259 GLU n 1 260 ARG n 1 261 ASP n 1 262 ILE n 1 263 CSO n 1 264 ILE n 1 265 ASP n 1 266 PHE n 1 267 SER n 1 268 GLU n 1 269 LEU n 1 270 ILE n 1 271 SER n 1 272 GLN n 1 273 TYR n 1 274 SER n 1 275 ASP n 1 276 GLU n 1 277 GLU n 1 278 GLU n 1 279 ILE n 1 280 GLN n 1 281 HIS n 1 282 VAL n 1 283 VAL n 1 284 GLU n 1 285 VAL n 1 286 ILE n 1 287 GLN n 1 288 ASN n 1 289 SER n 1 290 THR n 1 291 ALA n 1 292 LYS n 1 293 VAL n 1 294 ILE n 1 295 VAL n 1 296 VAL n 1 297 PHE n 1 298 SER n 1 299 SER n 1 300 GLY n 1 301 PRO n 1 302 ASP n 1 303 LEU n 1 304 GLU n 1 305 PRO n 1 306 LEU n 1 307 ILE n 1 308 LYS n 1 309 GLU n 1 310 ILE n 1 311 VAL n 1 312 ARG n 1 313 ARG n 1 314 ASN n 1 315 ILE n 1 316 THR n 1 317 GLY n 1 318 LYS n 1 319 ILE n 1 320 TRP n 1 321 LEU n 1 322 ALA n 1 323 SER n 1 324 GLU n 1 325 ALA n 1 326 TRP n 1 327 ALA n 1 328 SER n 1 329 SER n 1 330 SER n 1 331 LEU n 1 332 ILE n 1 333 ALA n 1 334 MET n 1 335 PRO n 1 336 GLN n 1 337 TYR n 1 338 PHE n 1 339 HIS n 1 340 VAL n 1 341 VAL n 1 342 GLY n 1 343 GLY n 1 344 THR n 1 345 ILE n 1 346 GLY n 1 347 PHE n 1 348 ALA n 1 349 LEU n 1 350 LYS n 1 351 ALA n 1 352 GLY n 1 353 GLN n 1 354 ILE n 1 355 PRO n 1 356 GLY n 1 357 PHE n 1 358 ARG n 1 359 GLU n 1 360 PHE n 1 361 LEU n 1 362 LYS n 1 363 LYS n 1 364 VAL n 1 365 HIS n 1 366 PRO n 1 367 ARG n 1 368 LYS n 1 369 SER n 1 370 VAL n 1 371 HIS n 1 372 ASN n 1 373 GLY n 1 374 PHE n 1 375 ALA n 1 376 LYS n 1 377 GLU n 1 378 PHE n 1 379 TRP n 1 380 GLU n 1 381 GLU n 1 382 THR n 1 383 PHE n 1 384 ASN n 1 385 CYS n 1 386 HIS n 1 387 LEU n 1 388 GLN n 1 389 GLU n 1 390 GLY n 1 391 ALA n 1 392 LYS n 1 393 GLY n 1 394 PRO n 1 395 LEU n 1 396 PRO n 1 397 VAL n 1 398 ASP n 1 399 THR n 1 400 PHE n 1 401 LEU n 1 402 ARG n 1 403 GLY n 1 404 HIS n 1 405 GLU n 1 406 GLU n 1 407 SER n 1 408 GLY n 1 409 ASP n 1 410 ARG n 1 411 PHE n 1 412 SER n 1 413 ASN n 1 414 SER n 1 415 SER n 1 416 THR n 1 417 ALA n 1 418 PHE n 1 419 ARG n 1 420 PRO n 1 421 LEU n 1 422 CYS n 1 423 THR n 1 424 GLY n 1 425 ASP n 1 426 GLU n 1 427 ASN n 1 428 ILE n 1 429 SER n 1 430 SER n 1 431 VAL n 1 432 GLU n 1 433 THR n 1 434 PRO n 1 435 TYR n 1 436 ILE n 1 437 ASP n 1 438 TYR n 1 439 THR n 1 440 HIS n 1 441 LEU n 1 442 ARG n 1 443 ILE n 1 444 SER n 1 445 TYR n 1 446 ASN n 1 447 VAL n 1 448 TYR n 1 449 LEU n 1 450 ALA n 1 451 VAL n 1 452 TYR n 1 453 SER n 1 454 ILE n 1 455 ALA n 1 456 HIS n 1 457 ALA n 1 458 LEU n 1 459 GLN n 1 460 ASP n 1 461 ILE n 1 462 TYR n 1 463 THR n 1 464 CYS n 1 465 LEU n 1 466 PRO n 1 467 GLY n 1 468 ARG n 1 469 GLY n 1 470 LEU n 1 471 PHE n 1 472 THR n 1 473 ASN n 1 474 GLY n 1 475 SER n 1 476 CYS n 1 477 ALA n 1 478 ASP n 1 479 ILE n 1 480 LYS n 1 481 LYS n 1 482 VAL n 1 483 GLU n 1 484 ALA n 1 485 TRP n 1 486 GLN n 1 487 VAL n 1 488 LEU n 1 489 LYS n 1 490 HIS n 1 491 LEU n 1 492 ARG n 1 493 HIS n 1 494 LEU n 1 495 ASN n 1 496 PHE n 1 497 THR n 1 498 ASN n 1 499 ASN n 1 500 MET n 1 501 GLY n 1 502 GLU n 1 503 GLN n 1 504 VAL n 1 505 THR n 1 506 PHE n 1 507 ASP n 1 508 GLU n 1 509 CSO n 1 510 GLY n 1 511 ASP n 1 512 LEU n 1 513 VAL n 1 514 GLY n 1 515 ASN n 1 516 TYR n 1 517 SER n 1 518 ILE n 1 519 ILE n 1 520 ASN n 1 521 TRP n 1 522 HIS n 1 523 LEU n 1 524 SER n 1 525 PRO n 1 526 GLU n 1 527 ASP n 1 528 GLY n 1 529 SER n 1 530 ILE n 1 531 VAL n 1 532 PHE n 1 533 LYS n 1 534 GLU n 1 535 VAL n 1 536 GLY n 1 537 TYR n 1 538 TYR n 1 539 ASN n 1 540 VAL n 1 541 TYR n 1 542 ALA n 1 543 LYS n 1 544 LYS n 1 545 GLY n 1 546 GLU n 1 547 ARG n 1 548 LEU n 1 549 PHE n 1 550 ILE n 1 551 ASN n 1 552 GLU n 1 553 GLU n 1 554 LYS n 1 555 ILE n 1 556 LEU n 1 557 TRP n 1 558 SER n 1 559 GLY n 1 560 PHE n 1 561 SER n 1 562 ARG n 1 563 GLU n 1 564 VAL n 1 565 PRO n 1 566 PHE n 1 567 SER n 1 568 ASN n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type 'Biological sequence' _entity_src_gen.pdbx_beg_seq_num 1 _entity_src_gen.pdbx_end_seq_num 568 _entity_src_gen.gene_src_common_name Human _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene 'CASR, GPRC2A, PCAR1' _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Homo sapiens' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 9606 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'Homo sapiens' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 9606 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain ? _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line HEK293 _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type ? _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name ? _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.db_code CASR_HUMAN _struct_ref.db_name UNP _struct_ref.details ? _struct_ref.entity_id 1 _struct_ref.id 1 _struct_ref.seq_align ? _struct_ref.seq_dif ? _struct_ref.pdbx_db_accession P41180 _struct_ref.pdbx_db_isoform ? _struct_ref.pdbx_seq_one_letter_code ;YGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFD TCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQ FKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVI QNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHP RKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYN VYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPE DGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSN ; _struct_ref.pdbx_align_begin 20 _struct_ref.pdbx_align_end ? # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 5FBH B 47 ? 568 ? P41180 20 ? 541 ? 20 541 2 1 5FBH A 47 ? 568 ? P41180 20 ? 541 ? 20 541 # loop_ _struct_ref_seq_dif.align_id _struct_ref_seq_dif.pdbx_pdb_id_code _struct_ref_seq_dif.mon_id _struct_ref_seq_dif.pdbx_pdb_strand_id _struct_ref_seq_dif.seq_num _struct_ref_seq_dif.pdbx_pdb_ins_code _struct_ref_seq_dif.pdbx_seq_db_name _struct_ref_seq_dif.pdbx_seq_db_accession_code _struct_ref_seq_dif.db_mon_id _struct_ref_seq_dif.pdbx_seq_db_seq_num _struct_ref_seq_dif.details _struct_ref_seq_dif.pdbx_auth_seq_num _struct_ref_seq_dif.pdbx_ordinal 1 5FBH MET B 1 ? UNP P41180 ? ? 'initiating methionine' -26 1 1 5FBH ARG B 2 ? UNP P41180 ? ? 'expression tag' -25 2 1 5FBH LEU B 3 ? UNP P41180 ? ? 'expression tag' -24 3 1 5FBH LEU B 4 ? UNP P41180 ? ? 'expression tag' -23 4 1 5FBH THR B 5 ? UNP P41180 ? ? 'expression tag' -22 5 1 5FBH ALA B 6 ? UNP P41180 ? ? 'expression tag' -21 6 1 5FBH LEU B 7 ? UNP P41180 ? ? 'expression tag' -20 7 1 5FBH PHE B 8 ? UNP P41180 ? ? 'expression tag' -19 8 1 5FBH ALA B 9 ? UNP P41180 ? ? 'expression tag' -18 9 1 5FBH TYR B 10 ? UNP P41180 ? ? 'expression tag' -17 10 1 5FBH PHE B 11 ? UNP P41180 ? ? 'expression tag' -16 11 1 5FBH ILE B 12 ? UNP P41180 ? ? 'expression tag' -15 12 1 5FBH VAL B 13 ? UNP P41180 ? ? 'expression tag' -14 13 1 5FBH ALA B 14 ? UNP P41180 ? ? 'expression tag' -13 14 1 5FBH LEU B 15 ? UNP P41180 ? ? 'expression tag' -12 15 1 5FBH ILE B 16 ? UNP P41180 ? ? 'expression tag' -11 16 1 5FBH LEU B 17 ? UNP P41180 ? ? 'expression tag' -10 17 1 5FBH ALA B 18 ? UNP P41180 ? ? 'expression tag' -9 18 1 5FBH PHE B 19 ? UNP P41180 ? ? 'expression tag' -8 19 1 5FBH SER B 20 ? UNP P41180 ? ? 'expression tag' -7 20 1 5FBH VAL B 21 ? UNP P41180 ? ? 'expression tag' -6 21 1 5FBH SER B 22 ? UNP P41180 ? ? 'expression tag' -5 22 1 5FBH ALA B 23 ? UNP P41180 ? ? 'expression tag' -4 23 1 5FBH LYS B 24 ? UNP P41180 ? ? 'expression tag' -3 24 1 5FBH SER B 25 ? UNP P41180 ? ? 'expression tag' -2 25 1 5FBH MET B 26 ? UNP P41180 ? ? 'expression tag' -1 26 1 5FBH HIS B 27 ? UNP P41180 ? ? 'expression tag' 0 27 1 5FBH HIS B 28 ? UNP P41180 ? ? 'expression tag' 1 28 1 5FBH HIS B 29 ? UNP P41180 ? ? 'expression tag' 2 29 1 5FBH HIS B 30 ? UNP P41180 ? ? 'expression tag' 3 30 1 5FBH HIS B 31 ? UNP P41180 ? ? 'expression tag' 4 31 1 5FBH HIS B 32 ? UNP P41180 ? ? 'expression tag' 5 32 1 5FBH HIS B 33 ? UNP P41180 ? ? 'expression tag' 6 33 1 5FBH HIS B 34 ? UNP P41180 ? ? 'expression tag' 7 34 1 5FBH SER B 35 ? UNP P41180 ? ? 'expression tag' 8 35 1 5FBH ALA B 36 ? UNP P41180 ? ? 'expression tag' 9 36 1 5FBH TRP B 37 ? UNP P41180 ? ? 'expression tag' 10 37 1 5FBH SER B 38 ? UNP P41180 ? ? 'expression tag' 11 38 1 5FBH HIS B 39 ? UNP P41180 ? ? 'expression tag' 12 39 1 5FBH PRO B 40 ? UNP P41180 ? ? 'expression tag' 13 40 1 5FBH GLN B 41 ? UNP P41180 ? ? 'expression tag' 14 41 1 5FBH PHE B 42 ? UNP P41180 ? ? 'expression tag' 15 42 1 5FBH GLU B 43 ? UNP P41180 ? ? 'expression tag' 16 43 1 5FBH LYS B 44 ? UNP P41180 ? ? 'expression tag' 17 44 1 5FBH GLU B 45 ? UNP P41180 ? ? 'expression tag' 18 45 1 5FBH PHE B 46 ? UNP P41180 ? ? 'expression tag' 19 46 2 5FBH MET A 1 ? UNP P41180 ? ? 'initiating methionine' -26 47 2 5FBH ARG A 2 ? UNP P41180 ? ? 'expression tag' -25 48 2 5FBH LEU A 3 ? UNP P41180 ? ? 'expression tag' -24 49 2 5FBH LEU A 4 ? UNP P41180 ? ? 'expression tag' -23 50 2 5FBH THR A 5 ? UNP P41180 ? ? 'expression tag' -22 51 2 5FBH ALA A 6 ? UNP P41180 ? ? 'expression tag' -21 52 2 5FBH LEU A 7 ? UNP P41180 ? ? 'expression tag' -20 53 2 5FBH PHE A 8 ? UNP P41180 ? ? 'expression tag' -19 54 2 5FBH ALA A 9 ? UNP P41180 ? ? 'expression tag' -18 55 2 5FBH TYR A 10 ? UNP P41180 ? ? 'expression tag' -17 56 2 5FBH PHE A 11 ? UNP P41180 ? ? 'expression tag' -16 57 2 5FBH ILE A 12 ? UNP P41180 ? ? 'expression tag' -15 58 2 5FBH VAL A 13 ? UNP P41180 ? ? 'expression tag' -14 59 2 5FBH ALA A 14 ? UNP P41180 ? ? 'expression tag' -13 60 2 5FBH LEU A 15 ? UNP P41180 ? ? 'expression tag' -12 61 2 5FBH ILE A 16 ? UNP P41180 ? ? 'expression tag' -11 62 2 5FBH LEU A 17 ? UNP P41180 ? ? 'expression tag' -10 63 2 5FBH ALA A 18 ? UNP P41180 ? ? 'expression tag' -9 64 2 5FBH PHE A 19 ? UNP P41180 ? ? 'expression tag' -8 65 2 5FBH SER A 20 ? UNP P41180 ? ? 'expression tag' -7 66 2 5FBH VAL A 21 ? UNP P41180 ? ? 'expression tag' -6 67 2 5FBH SER A 22 ? UNP P41180 ? ? 'expression tag' -5 68 2 5FBH ALA A 23 ? UNP P41180 ? ? 'expression tag' -4 69 2 5FBH LYS A 24 ? UNP P41180 ? ? 'expression tag' -3 70 2 5FBH SER A 25 ? UNP P41180 ? ? 'expression tag' -2 71 2 5FBH MET A 26 ? UNP P41180 ? ? 'expression tag' -1 72 2 5FBH HIS A 27 ? UNP P41180 ? ? 'expression tag' 0 73 2 5FBH HIS A 28 ? UNP P41180 ? ? 'expression tag' 1 74 2 5FBH HIS A 29 ? UNP P41180 ? ? 'expression tag' 2 75 2 5FBH HIS A 30 ? UNP P41180 ? ? 'expression tag' 3 76 2 5FBH HIS A 31 ? UNP P41180 ? ? 'expression tag' 4 77 2 5FBH HIS A 32 ? UNP P41180 ? ? 'expression tag' 5 78 2 5FBH HIS A 33 ? UNP P41180 ? ? 'expression tag' 6 79 2 5FBH HIS A 34 ? UNP P41180 ? ? 'expression tag' 7 80 2 5FBH SER A 35 ? UNP P41180 ? ? 'expression tag' 8 81 2 5FBH ALA A 36 ? UNP P41180 ? ? 'expression tag' 9 82 2 5FBH TRP A 37 ? UNP P41180 ? ? 'expression tag' 10 83 2 5FBH SER A 38 ? UNP P41180 ? ? 'expression tag' 11 84 2 5FBH HIS A 39 ? UNP P41180 ? ? 'expression tag' 12 85 2 5FBH PRO A 40 ? UNP P41180 ? ? 'expression tag' 13 86 2 5FBH GLN A 41 ? UNP P41180 ? ? 'expression tag' 14 87 2 5FBH PHE A 42 ? UNP P41180 ? ? 'expression tag' 15 88 2 5FBH GLU A 43 ? UNP P41180 ? ? 'expression tag' 16 89 2 5FBH LYS A 44 ? UNP P41180 ? ? 'expression tag' 17 90 2 5FBH GLU A 45 ? UNP P41180 ? ? 'expression tag' 18 91 2 5FBH PHE A 46 ? UNP P41180 ? ? 'expression tag' 19 92 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 BCT non-polymer . 'BICARBONATE ION' ? 'C H O3 -1' 61.017 CL non-polymer . 'CHLORIDE ION' ? 'Cl -1' 35.453 CSO 'L-peptide linking' n S-HYDROXYCYSTEINE ? 'C3 H7 N O3 S' 137.158 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GD3 non-polymer . 'GADOLINIUM ION' ? 'Gd 3' 157.250 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 MG non-polymer . 'MAGNESIUM ION' ? 'Mg 2' 24.305 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 TCR 'L-peptide linking' n CYCLOMETHYLTRYPTOPHAN ? 'C12 H12 N2 O2' 216.236 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.absorpt_coefficient_mu ? _exptl.absorpt_correction_T_max ? _exptl.absorpt_correction_T_min ? _exptl.absorpt_correction_type ? _exptl.absorpt_process_details ? _exptl.entry_id 5FBH _exptl.crystals_number 1 _exptl.details ? _exptl.method 'X-RAY DIFFRACTION' _exptl.method_details ? # _exptl_crystal.colour ? _exptl_crystal.density_diffrn ? _exptl_crystal.density_Matthews 2.54 _exptl_crystal.density_method ? _exptl_crystal.density_percent_sol 51.58 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.id 1 _exptl_crystal.preparation ? _exptl_crystal.size_max ? _exptl_crystal.size_mid ? _exptl_crystal.size_min ? _exptl_crystal.size_rad ? _exptl_crystal.colour_lustre ? _exptl_crystal.colour_modifier ? _exptl_crystal.colour_primary ? _exptl_crystal.density_meas ? _exptl_crystal.density_meas_esd ? _exptl_crystal.density_meas_gt ? _exptl_crystal.density_meas_lt ? _exptl_crystal.density_meas_temp ? _exptl_crystal.density_meas_temp_esd ? _exptl_crystal.density_meas_temp_gt ? _exptl_crystal.density_meas_temp_lt ? _exptl_crystal.pdbx_crystal_image_url ? _exptl_crystal.pdbx_crystal_image_format ? _exptl_crystal.pdbx_mosaicity ? _exptl_crystal.pdbx_mosaicity_esd ? # _exptl_crystal_grow.apparatus ? _exptl_crystal_grow.atmosphere ? _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.details ? _exptl_crystal_grow.method 'VAPOR DIFFUSION, SITTING DROP' _exptl_crystal_grow.method_ref ? _exptl_crystal_grow.pH 7.0 _exptl_crystal_grow.pressure ? _exptl_crystal_grow.pressure_esd ? _exptl_crystal_grow.seeding ? _exptl_crystal_grow.seeding_ref ? _exptl_crystal_grow.temp 294 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.temp_esd ? _exptl_crystal_grow.time ? _exptl_crystal_grow.pdbx_details '10% PEG 8000, 200 mM MgCl2, 10 mM CaCl2 and 100 mM Tris-HCl, 0.5 mM GdCl3' _exptl_crystal_grow.pdbx_pH_range ? # _diffrn.ambient_environment ? _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.ambient_temp_esd ? _diffrn.crystal_id 1 _diffrn.crystal_support ? _diffrn.crystal_treatment ? _diffrn.details ? _diffrn.id 1 _diffrn.ambient_pressure ? _diffrn.ambient_pressure_esd ? _diffrn.ambient_pressure_gt ? _diffrn.ambient_pressure_lt ? _diffrn.ambient_temp_gt ? _diffrn.ambient_temp_lt ? # _diffrn_detector.details ? _diffrn_detector.detector CCD _diffrn_detector.diffrn_id 1 _diffrn_detector.type 'MARMOSAIC 300 mm CCD' _diffrn_detector.area_resol_mean ? _diffrn_detector.dtime ? _diffrn_detector.pdbx_frames_total ? _diffrn_detector.pdbx_collection_time_total ? _diffrn_detector.pdbx_collection_date 2015-11-21 # _diffrn_radiation.collimation ? _diffrn_radiation.diffrn_id 1 _diffrn_radiation.filter_edge ? _diffrn_radiation.inhomogeneity ? _diffrn_radiation.monochromator ? _diffrn_radiation.polarisn_norm ? _diffrn_radiation.polarisn_ratio ? _diffrn_radiation.probe ? _diffrn_radiation.type ? _diffrn_radiation.xray_symbol ? _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.pdbx_wavelength_list ? _diffrn_radiation.pdbx_wavelength ? _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_analyzer ? _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 1.6985 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.current ? _diffrn_source.details ? _diffrn_source.diffrn_id 1 _diffrn_source.power ? _diffrn_source.size ? _diffrn_source.source SYNCHROTRON _diffrn_source.target ? _diffrn_source.type 'APS BEAMLINE 21-ID-D' _diffrn_source.voltage ? _diffrn_source.take-off_angle ? _diffrn_source.pdbx_wavelength_list 1.6985 _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_synchrotron_beamline 21-ID-D _diffrn_source.pdbx_synchrotron_site APS # _reflns.d_resolution_high 2.700 _reflns.d_resolution_low 50.000 _reflns.pdbx_number_measured_all 125177 _reflns.number_obs 34777 _reflns.pdbx_Rmerge_I_obs 0.093 _reflns.pdbx_netI_over_av_sigmaI 11.901 _reflns.pdbx_netI_over_sigmaI 11.800 _reflns.pdbx_chi_squared 1.061 _reflns.pdbx_redundancy 3.600 _reflns.percent_possible_obs 98.900 _reflns.pdbx_Rrim_I_all 0.110 _reflns.pdbx_Rpim_I_all 0.058 _reflns.pdbx_diffrn_id 1 _reflns.pdbx_ordinal 1 _reflns.entry_id 5FBH _reflns.observed_criterion_sigma_I ? _reflns.observed_criterion_sigma_F ? _reflns.number_all ? _reflns.pdbx_Rsym_value ? _reflns.B_iso_Wilson_estimate ? # loop_ _reflns_shell.pdbx_diffrn_id _reflns_shell.pdbx_ordinal _reflns_shell.d_res_high _reflns_shell.d_res_low _reflns_shell.number_measured_obs _reflns_shell.number_measured_all _reflns_shell.number_unique_obs _reflns_shell.pdbx_rejects _reflns_shell.Rmerge_I_obs _reflns_shell.meanI_over_sigI_obs _reflns_shell.pdbx_Rsym_value _reflns_shell.pdbx_chi_squared _reflns_shell.pdbx_redundancy _reflns_shell.percent_possible_obs _reflns_shell.pdbx_netI_over_sigmaI_obs _reflns_shell.number_possible _reflns_shell.number_unique_all _reflns_shell.Rmerge_F_all _reflns_shell.Rmerge_F_obs _reflns_shell.Rmerge_I_all _reflns_shell.meanI_over_sigI_all _reflns_shell.percent_possible_all _reflns_shell.pdbx_Rrim_I_all _reflns_shell.pdbx_Rpim_I_all _reflns_shell.pdbx_CC_half 1 1 2.700 2.800 ? ? ? 0 0.772 ? ? 1.043 3.600 ? ? ? 3480 ? ? ? ? 99.900 0.905 0.468 0.645 1 2 2.800 2.910 ? ? ? 0 0.529 ? ? 1.092 3.700 ? ? ? 3507 ? ? ? ? 100.000 0.619 0.319 0.773 1 3 2.910 3.040 ? ? ? 0 0.374 ? ? 1.079 3.700 ? ? ? 3478 ? ? ? ? 99.900 0.439 0.227 0.862 1 4 3.040 3.200 ? ? ? 0 0.260 ? ? 1.074 3.700 ? ? ? 3485 ? ? ? ? 99.700 0.306 0.159 0.918 1 5 3.200 3.400 ? ? ? 0 0.174 ? ? 1.096 3.700 ? ? ? 3493 ? ? ? ? 99.500 0.205 0.106 0.959 1 6 3.400 3.660 ? ? ? 0 0.124 ? ? 1.094 3.700 ? ? ? 3492 ? ? ? ? 99.300 0.145 0.076 0.979 1 7 3.660 4.030 ? ? ? 0 0.089 ? ? 1.057 3.600 ? ? ? 3447 ? ? ? ? 98.700 0.105 0.055 0.989 1 8 4.030 4.620 ? ? ? 0 0.070 ? ? 1.020 3.500 ? ? ? 3475 ? ? ? ? 98.700 0.083 0.044 0.991 1 9 4.620 5.810 ? ? ? 0 0.064 ? ? 1.043 3.500 ? ? ? 3474 ? ? ? ? 98.200 0.076 0.040 0.992 1 10 5.810 50.000 ? ? ? 0 0.059 ? ? 0.996 3.300 ? ? ? 3446 ? ? ? ? 95.200 0.072 0.040 0.991 # _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.entry_id 5FBH _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.ls_number_reflns_obs 33039 _refine.ls_number_reflns_all ? _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F 0.000 _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 46.08 _refine.ls_d_res_high 2.70 _refine.ls_percent_reflns_obs 97.4 _refine.ls_R_factor_obs 0.184 _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work 0.182 _refine.ls_R_factor_R_free 0.236 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 5.000 _refine.ls_number_reflns_R_free 1733 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc 0.956 _refine.correlation_coeff_Fo_to_Fc_free 0.931 _refine.B_iso_mean 65.27 _refine.aniso_B[1][1] -0.60000 _refine.aniso_B[2][2] 0.41000 _refine.aniso_B[3][3] 0.88000 _refine.aniso_B[1][2] 0.00000 _refine.aniso_B[1][3] -1.52000 _refine.aniso_B[2][3] 0.00000 _refine.solvent_model_details MASK _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.20 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details 'HYDROGENS HAVE BEEN ADDED IN THE RIDING' _refine.pdbx_starting_model ? _refine.pdbx_method_to_determine_struct ? _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R 0.741 _refine.pdbx_overall_ESU_R_Free 0.309 _refine.overall_SU_ML 0.233 _refine.pdbx_overall_phase_error ? _refine.overall_SU_B 11.524 _refine.overall_SU_R_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 7232 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 145 _refine_hist.number_atoms_solvent 17 _refine_hist.number_atoms_total 7394 _refine_hist.d_res_high 2.70 _refine_hist.d_res_low 46.08 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function r_bond_refined_d 0.012 0.019 ? 7577 'X-RAY DIFFRACTION' ? r_bond_other_d 0.002 0.020 ? 6857 'X-RAY DIFFRACTION' ? r_angle_refined_deg 1.578 1.957 ? 10324 'X-RAY DIFFRACTION' ? r_angle_other_deg 0.913 3.000 ? 15627 'X-RAY DIFFRACTION' ? r_dihedral_angle_1_deg 6.396 5.000 ? 936 'X-RAY DIFFRACTION' ? r_dihedral_angle_2_deg 32.835 23.814 ? 333 'X-RAY DIFFRACTION' ? r_dihedral_angle_3_deg 17.149 15.000 ? 1099 'X-RAY DIFFRACTION' ? r_dihedral_angle_4_deg 17.986 15.000 ? 37 'X-RAY DIFFRACTION' ? r_chiral_restr 0.087 0.200 ? 1160 'X-RAY DIFFRACTION' ? r_gen_planes_refined 0.006 0.020 ? 8671 'X-RAY DIFFRACTION' ? r_gen_planes_other 0.001 0.020 ? 1830 'X-RAY DIFFRACTION' ? r_nbd_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcbond_it 4.619 6.528 ? 3766 'X-RAY DIFFRACTION' ? r_mcbond_other 4.618 6.528 ? 3766 'X-RAY DIFFRACTION' ? r_mcangle_it 6.859 9.788 ? 4694 'X-RAY DIFFRACTION' ? r_mcangle_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_scbond_it ? ? ? ? 'X-RAY DIFFRACTION' ? r_scbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_scangle_it ? ? ? ? 'X-RAY DIFFRACTION' ? r_scangle_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_long_range_B_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_long_range_B_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_rigid_bond_restr ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_free ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_bonded ? ? ? ? 'X-RAY DIFFRACTION' ? # _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.d_res_high 2.70 _refine_ls_shell.d_res_low 2.77 _refine_ls_shell.number_reflns_R_work 1994 _refine_ls_shell.R_factor_R_work 0.3430 _refine_ls_shell.percent_reflns_obs 79.44 _refine_ls_shell.R_factor_R_free 0.3880 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.number_reflns_R_free 108 _refine_ls_shell.number_reflns_all ? _refine_ls_shell.R_factor_all ? _refine_ls_shell.R_factor_obs ? _refine_ls_shell.number_reflns_obs ? # _struct.entry_id 5FBH _struct.title 'Crystal structure of the extracellular domain of human calcium sensing receptor with bound Gd3+' _struct.pdbx_descriptor 'Extracellular calcium-sensing receptor' _struct.pdbx_model_details ? _struct.pdbx_formula_weight ? _struct.pdbx_formula_weight_method ? _struct.pdbx_model_type_details ? _struct.pdbx_CASP_flag ? # _struct_keywords.entry_id 5FBH _struct_keywords.text 'membrane protein, G-protein coupled receptor, SIGNALING PROTEIN' _struct_keywords.pdbx_keywords 'SIGNALING PROTEIN' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 1 ? C N N 2 ? D N N 3 ? E N N 3 ? F N N 4 ? G N N 5 ? H N N 6 ? I N N 6 ? J N N 6 ? K N N 7 ? L N N 2 ? M N N 3 ? N N N 4 ? O N N 5 ? P N N 6 ? Q N N 6 ? R N N 6 ? S N N 6 ? T N N 7 ? U N N 8 ? V N N 8 ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 AA1 ASN A 91 ? SER A 111 ? ASN B 64 SER B 84 1 ? 21 HELX_P HELX_P2 AA2 THR A 130 ? VAL A 142 ? THR B 103 VAL B 115 1 ? 13 HELX_P HELX_P3 AA3 VAL A 142 ? ASP A 148 ? VAL B 115 ASP B 121 1 ? 7 HELX_P HELX_P4 AA4 GLY A 173 ? GLY A 185 ? GLY B 146 GLY B 158 1 ? 13 HELX_P HELX_P5 AA5 LEU A 186 ? TYR A 188 ? LEU B 159 TYR B 161 5 ? 3 HELX_P HELX_P6 AA6 SER A 198 ? ASN A 203 ? SER B 171 ASN B 176 5 ? 6 HELX_P HELX_P7 AA7 ASN A 216 ? PHE A 231 ? ASN B 189 PHE B 204 1 ? 16 HELX_P HELX_P8 AA8 TYR A 245 ? ARG A 260 ? TYR B 218 ARG B 233 1 ? 16 HELX_P HELX_P9 AA9 ASP A 275 ? ASN A 288 ? ASP B 248 ASN B 261 1 ? 14 HELX_P HELX_P10 AB1 SER A 299 ? ARG A 313 ? SER B 272 ARG B 286 1 ? 15 HELX_P HELX_P11 AB2 MET A 334 ? GLN A 336 ? MET B 307 GLN B 309 5 ? 3 HELX_P HELX_P12 AB3 TYR A 337 ? GLY A 342 ? TYR B 310 GLY B 315 1 ? 6 HELX_P HELX_P13 AB4 GLY A 356 ? LYS A 362 ? GLY B 329 LYS B 335 1 ? 7 HELX_P HELX_P14 AB5 PHE A 374 ? ASN A 384 ? PHE B 347 ASN B 357 1 ? 11 HELX_P HELX_P15 AB6 ASN A 427 ? VAL A 431 ? ASN B 400 VAL B 404 5 ? 5 HELX_P HELX_P16 AB7 ARG A 442 ? THR A 463 ? ARG B 415 THR B 436 1 ? 22 HELX_P HELX_P17 AB8 PHE A 471 ? SER A 475 ? PHE B 444 SER B 448 5 ? 5 HELX_P HELX_P18 AB9 ASP A 478 ? VAL A 482 ? ASP B 451 VAL B 455 5 ? 5 HELX_P HELX_P19 AC1 GLU A 483 ? LEU A 494 ? GLU B 456 LEU B 467 1 ? 12 HELX_P HELX_P20 AC2 GLU A 552 ? ILE A 555 ? GLU B 525 ILE B 528 5 ? 4 HELX_P HELX_P21 AC3 ASN B 91 ? SER B 111 ? ASN A 64 SER A 84 1 ? 21 HELX_P HELX_P22 AC4 THR B 130 ? VAL B 142 ? THR A 103 VAL A 115 1 ? 13 HELX_P HELX_P23 AC5 VAL B 142 ? ASP B 148 ? VAL A 115 ASP A 121 1 ? 7 HELX_P HELX_P24 AC6 GLY B 173 ? PHE B 187 ? GLY A 146 PHE A 160 1 ? 15 HELX_P HELX_P25 AC7 SER B 198 ? ASN B 203 ? SER A 171 ASN A 176 5 ? 6 HELX_P HELX_P26 AC8 ASP B 217 ? PHE B 231 ? ASP A 190 PHE A 204 1 ? 15 HELX_P HELX_P27 AC9 TYR B 245 ? ARG B 260 ? TYR A 218 ARG A 233 1 ? 16 HELX_P HELX_P28 AD1 ASP B 275 ? ASN B 288 ? ASP A 248 ASN A 261 1 ? 14 HELX_P HELX_P29 AD2 SER B 299 ? ARG B 313 ? SER A 272 ARG A 286 1 ? 15 HELX_P HELX_P30 AD3 SER B 323 ? SER B 328 ? SER A 296 SER A 301 1 ? 6 HELX_P HELX_P31 AD4 MET B 334 ? GLN B 336 ? MET A 307 GLN A 309 5 ? 3 HELX_P HELX_P32 AD5 TYR B 337 ? GLY B 342 ? TYR A 310 GLY A 315 1 ? 6 HELX_P HELX_P33 AD6 GLY B 356 ? LYS B 363 ? GLY A 329 LYS A 336 1 ? 8 HELX_P HELX_P34 AD7 PHE B 374 ? ASN B 384 ? PHE A 347 ASN A 357 1 ? 11 HELX_P HELX_P35 AD8 ASN B 427 ? VAL B 431 ? ASN A 400 VAL A 404 5 ? 5 HELX_P HELX_P36 AD9 ARG B 442 ? THR B 463 ? ARG A 415 THR A 436 1 ? 22 HELX_P HELX_P37 AE1 PHE B 471 ? SER B 475 ? PHE A 444 SER A 448 5 ? 5 HELX_P HELX_P38 AE2 GLU B 483 ? LEU B 494 ? GLU A 456 LEU A 467 1 ? 12 HELX_P HELX_P39 AE3 GLU B 552 ? ILE B 555 ? GLU A 525 ILE A 528 5 ? 4 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 87 SG ? ? ? 1_555 A CYS 128 SG ? ? B CYS 60 B CYS 101 1_555 ? ? ? ? ? ? ? 2.017 ? disulf2 disulf ? ? A CYS 385 SG ? ? ? 1_555 A CYS 422 SG ? ? B CYS 358 B CYS 395 1_555 ? ? ? ? ? ? ? 2.047 ? disulf3 disulf ? ? A CYS 464 SG ? ? ? 1_555 A CYS 476 SG ? ? B CYS 437 B CYS 449 1_555 ? ? ? ? ? ? ? 2.058 ? disulf4 disulf ? ? B CYS 87 SG ? ? ? 1_555 B CYS 128 SG ? ? A CYS 60 A CYS 101 1_555 ? ? ? ? ? ? ? 2.041 ? disulf5 disulf ? ? B CYS 385 SG ? ? ? 1_555 B CYS 422 SG ? ? A CYS 358 A CYS 395 1_555 ? ? ? ? ? ? ? 2.042 ? disulf6 disulf ? ? B CYS 464 SG ? ? ? 1_555 B CYS 476 SG ? ? A CYS 437 A CYS 449 1_555 ? ? ? ? ? ? ? 2.058 ? metalc1 metalc ? ? A ILE 108 O ? ? ? 1_555 E MG . MG ? ? B ILE 81 B MG 603 1_555 ? ? ? ? ? ? ? 2.785 ? metalc2 metalc ? ? A LEU 114 O ? ? ? 1_555 E MG . MG ? ? B LEU 87 B MG 603 1_555 ? ? ? ? ? ? ? 2.920 ? metalc3 metalc ? ? A LEU 115 O ? ? ? 1_555 E MG . MG ? ? B LEU 88 B MG 603 1_555 ? ? ? ? ? ? ? 2.607 ? metalc4 metalc ? ? A GLU 256 OE1 ? ? ? 1_555 C GD3 . GD ? ? B GLU 229 B GD3 601 1_555 ? ? ? ? ? ? ? 2.735 ? metalc5 metalc ? ? A GLU 256 OE2 ? ? ? 1_555 C GD3 . GD ? ? B GLU 229 B GD3 601 1_555 ? ? ? ? ? ? ? 2.700 ? metalc6 metalc ? ? A GLU 259 OE1 ? ? ? 1_555 C GD3 . GD ? ? B GLU 232 B GD3 601 1_555 ? ? ? ? ? ? ? 2.681 ? covale1 covale both ? A ILE 262 C ? ? ? 1_555 A CSO 263 N ? ? B ILE 235 B CSO 236 1_555 ? ? ? ? ? ? ? 1.326 ? covale2 covale both ? A CSO 263 C ? ? ? 1_555 A ILE 264 N ? ? B CSO 236 B ILE 237 1_555 ? ? ? ? ? ? ? 1.326 ? metalc7 metalc ? ? A SER 267 O ? ? ? 1_555 D MG . MG ? ? B SER 240 B MG 602 1_555 ? ? ? ? ? ? ? 2.573 ? metalc8 metalc ? ? A SER 267 OG ? ? ? 1_555 D MG . MG ? ? B SER 240 B MG 602 1_555 ? ? ? ? ? ? ? 2.381 ? covale3 covale one ? A ASN 288 ND2 ? ? ? 1_555 H NAG . C1 ? ? B ASN 261 B NAG 606 1_555 ? ? ? ? ? ? ? 1.438 ? covale4 covale one ? A ASN 314 ND2 ? ? ? 1_555 I NAG . C1 ? ? B ASN 287 B NAG 607 1_555 ? ? ? ? ? ? ? 1.448 ? covale5 covale one ? A ASN 495 ND2 ? ? ? 1_555 J NAG . C1 ? ? B ASN 468 B NAG 608 1_555 ? ? ? ? ? ? ? 1.443 ? covale6 covale both ? A GLU 508 C ? ? ? 1_555 A CSO 509 N ? ? B GLU 481 B CSO 482 1_555 ? ? ? ? ? ? ? 1.330 ? covale7 covale both ? A CSO 509 C ? ? ? 1_555 A GLY 510 N ? ? B CSO 482 B GLY 483 1_555 ? ? ? ? ? ? ? 1.328 ? metalc9 metalc ? ? B ILE 108 O ? ? ? 1_555 M MG . MG ? ? A ILE 81 A MG 602 1_555 ? ? ? ? ? ? ? 2.521 ? metalc10 metalc ? ? B SER 111 O ? ? ? 1_555 M MG . MG ? ? A SER 84 A MG 602 1_555 ? ? ? ? ? ? ? 2.754 ? metalc11 metalc ? ? B LEU 114 O ? ? ? 1_555 M MG . MG ? ? A LEU 87 A MG 602 1_555 ? ? ? ? ? ? ? 2.526 ? metalc12 metalc ? ? B LEU 115 O ? ? ? 1_555 M MG . MG ? ? A LEU 88 A MG 602 1_555 ? ? ? ? ? ? ? 2.668 ? metalc13 metalc ? ? B GLU 256 OE1 ? ? ? 1_555 L GD3 . GD ? ? A GLU 229 A GD3 601 1_555 ? ? ? ? ? ? ? 2.732 ? metalc14 metalc ? ? B GLU 256 OE2 ? ? ? 1_555 L GD3 . GD ? ? A GLU 229 A GD3 601 1_555 ? ? ? ? ? ? ? 2.713 ? metalc15 metalc ? ? B GLU 259 OE1 ? ? ? 1_555 L GD3 . GD ? ? A GLU 232 A GD3 601 1_555 ? ? ? ? ? ? ? 2.526 ? covale8 covale both ? B ILE 262 C ? ? ? 1_555 B CSO 263 N ? ? A ILE 235 A CSO 236 1_555 ? ? ? ? ? ? ? 1.325 ? covale9 covale both ? B CSO 263 C ? ? ? 1_555 B ILE 264 N ? ? A CSO 236 A ILE 237 1_555 ? ? ? ? ? ? ? 1.333 ? covale10 covale one ? B ASN 288 ND2 ? ? ? 1_555 P NAG . C1 ? ? A ASN 261 A NAG 605 1_555 ? ? ? ? ? ? ? 1.444 ? covale11 covale one ? B ASN 314 ND2 ? ? ? 1_555 Q NAG . C1 ? ? A ASN 287 A NAG 606 1_555 ? ? ? ? ? ? ? 1.442 ? covale12 covale one ? B ASN 495 ND2 ? ? ? 1_555 R NAG . C1 ? ? A ASN 468 A NAG 607 1_555 ? ? ? ? ? ? ? 1.467 ? covale13 covale both ? B GLU 508 C ? ? ? 1_555 B CSO 509 N ? ? A GLU 481 A CSO 482 1_555 ? ? ? ? ? ? ? 1.343 ? covale14 covale both ? B CSO 509 C ? ? ? 1_555 B GLY 510 N ? ? A CSO 482 A GLY 483 1_555 ? ? ? ? ? ? ? 1.329 ? covale15 covale one ? B ASN 515 ND2 ? ? ? 1_555 S NAG . C1 ? ? A ASN 488 A NAG 608 1_555 ? ? ? ? ? ? ? 1.446 ? metalc16 metalc ? ? D MG . MG ? ? ? 1_555 U HOH . O ? ? B MG 602 B HOH 706 1_555 ? ? ? ? ? ? ? 2.539 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? metalc ? ? covale ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 GLY 170 A . ? GLY 143 B ALA 171 A ? ALA 144 B 1 -10.16 2 GLY 170 B . ? GLY 143 A ALA 171 B ? ALA 144 A 1 -12.12 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details AA1 ? 6 ? AA2 ? 2 ? AA3 ? 8 ? AA4 ? 2 ? AA5 ? 6 ? AA6 ? 2 ? AA7 ? 8 ? AA8 ? 2 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense AA1 1 2 ? anti-parallel AA1 2 3 ? parallel AA1 3 4 ? parallel AA1 4 5 ? parallel AA1 5 6 ? parallel AA2 1 2 ? anti-parallel AA3 1 2 ? parallel AA3 2 3 ? parallel AA3 3 4 ? parallel AA3 4 5 ? parallel AA3 5 6 ? anti-parallel AA3 6 7 ? anti-parallel AA3 7 8 ? anti-parallel AA4 1 2 ? anti-parallel AA5 1 2 ? anti-parallel AA5 2 3 ? parallel AA5 3 4 ? parallel AA5 4 5 ? parallel AA5 5 6 ? parallel AA6 1 2 ? anti-parallel AA7 1 2 ? parallel AA7 2 3 ? parallel AA7 3 4 ? parallel AA7 4 5 ? parallel AA7 5 6 ? anti-parallel AA7 6 7 ? anti-parallel AA7 7 8 ? anti-parallel AA8 1 2 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id AA1 1 ALA A 53 ? LYS A 55 ? ALA B 26 LYS B 28 AA1 2 LEU A 120 ? ASP A 126 ? LEU B 93 ASP B 99 AA1 3 ILE A 59 ? PHE A 65 ? ILE B 32 PHE B 38 AA1 4 THR A 165 ? VAL A 169 ? THR B 138 VAL B 142 AA1 5 GLN A 191 ? SER A 193 ? GLN B 164 SER B 166 AA1 6 PHE A 210 ? ARG A 212 ? PHE B 183 ARG B 185 AA2 1 HIS A 68 ? VAL A 71 ? HIS B 41 VAL B 44 AA2 2 CYS A 87 ? TYR A 90 ? CYS B 60 TYR B 63 AA3 1 CSO A 263 ? ILE A 270 ? CSO B 236 ILE B 243 AA3 2 TRP A 235 ? ALA A 241 ? TRP B 208 ALA B 214 AA3 3 VAL A 293 ? PHE A 297 ? VAL B 266 PHE B 270 AA3 4 ILE A 319 ? ALA A 322 ? ILE B 292 ALA B 295 AA3 5 ILE A 345 ? LEU A 349 ? ILE B 318 LEU B 322 AA3 6 TYR A 516 ? LEU A 523 ? TYR B 489 LEU B 496 AA3 7 ILE A 530 ? TYR A 538 ? ILE B 503 TYR B 511 AA3 8 LEU A 548 ? ILE A 550 ? LEU B 521 ILE B 523 AA4 1 PHE A 496 ? THR A 497 ? PHE B 469 THR B 470 AA4 2 GLN A 503 ? VAL A 504 ? GLN B 476 VAL B 477 AA5 1 ALA B 53 ? LYS B 55 ? ALA A 26 LYS A 28 AA5 2 LEU B 120 ? ASP B 126 ? LEU A 93 ASP A 99 AA5 3 ILE B 59 ? PHE B 65 ? ILE A 32 PHE A 38 AA5 4 THR B 165 ? VAL B 169 ? THR A 138 VAL A 142 AA5 5 GLN B 191 ? SER B 193 ? GLN A 164 SER A 166 AA5 6 PHE B 210 ? ARG B 212 ? PHE A 183 ARG A 185 AA6 1 HIS B 68 ? VAL B 71 ? HIS A 41 VAL A 44 AA6 2 CYS B 87 ? TYR B 90 ? CYS A 60 TYR A 63 AA7 1 CSO B 263 ? ILE B 270 ? CSO A 236 ILE A 243 AA7 2 TRP B 235 ? ALA B 241 ? TRP A 208 ALA A 214 AA7 3 VAL B 293 ? PHE B 297 ? VAL A 266 PHE A 270 AA7 4 ILE B 319 ? ALA B 322 ? ILE A 292 ALA A 295 AA7 5 ILE B 345 ? ALA B 348 ? ILE A 318 ALA A 321 AA7 6 TYR B 516 ? LEU B 523 ? TYR A 489 LEU A 496 AA7 7 ILE B 530 ? TYR B 538 ? ILE A 503 TYR A 511 AA7 8 LEU B 548 ? ILE B 550 ? LEU A 521 ILE A 523 AA8 1 ASN B 495 ? THR B 497 ? ASN A 468 THR A 470 AA8 2 GLN B 503 ? THR B 505 ? GLN A 476 THR A 478 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id AA1 1 2 N ALA A 53 ? N ALA B 26 O ILE A 124 ? O ILE B 97 AA1 2 3 O GLY A 121 ? O GLY B 94 N ILE A 59 ? N ILE B 32 AA1 3 4 N ILE A 60 ? N ILE B 33 O ILE A 166 ? O ILE B 139 AA1 4 5 N VAL A 168 ? N VAL B 141 O VAL A 192 ? O VAL B 165 AA1 5 6 N GLN A 191 ? N GLN B 164 O LEU A 211 ? O LEU B 184 AA2 1 2 N GLY A 70 ? N GLY B 43 O ILE A 88 ? O ILE B 61 AA3 1 2 O ASP A 265 ? O ASP B 238 N VAL A 236 ? N VAL B 209 AA3 2 3 N GLY A 237 ? N GLY B 210 O VAL A 295 ? O VAL B 268 AA3 3 4 N ILE A 294 ? N ILE B 267 O ILE A 319 ? O ILE B 292 AA3 4 5 N ALA A 322 ? N ALA B 295 O ILE A 345 ? O ILE B 318 AA3 5 6 N ALA A 348 ? N ALA B 321 O SER A 517 ? O SER B 490 AA3 6 7 N ASN A 520 ? N ASN B 493 O LYS A 533 ? O LYS B 506 AA3 7 8 N TYR A 537 ? N TYR B 510 O PHE A 549 ? O PHE B 522 AA4 1 2 N PHE A 496 ? N PHE B 469 O VAL A 504 ? O VAL B 477 AA5 1 2 N ALA B 53 ? N ALA A 26 O ILE B 124 ? O ILE A 97 AA5 2 3 O GLY B 121 ? O GLY A 94 N ILE B 59 ? N ILE A 32 AA5 3 4 N GLY B 62 ? N GLY A 35 O ALA B 167 ? O ALA A 140 AA5 4 5 N VAL B 168 ? N VAL A 141 O VAL B 192 ? O VAL A 165 AA5 5 6 N SER B 193 ? N SER A 166 O LEU B 211 ? O LEU A 184 AA6 1 2 N GLY B 70 ? N GLY A 43 O ILE B 88 ? O ILE A 61 AA7 1 2 O ASP B 265 ? O ASP A 238 N VAL B 236 ? N VAL A 209 AA7 2 3 N GLY B 237 ? N GLY A 210 O VAL B 293 ? O VAL A 266 AA7 3 4 N ILE B 294 ? N ILE A 267 O ILE B 319 ? O ILE A 292 AA7 4 5 N ALA B 322 ? N ALA A 295 O ILE B 345 ? O ILE A 318 AA7 5 6 N ALA B 348 ? N ALA A 321 O SER B 517 ? O SER A 490 AA7 6 7 N ILE B 518 ? N ILE A 491 O VAL B 535 ? O VAL A 508 AA7 7 8 N TYR B 537 ? N TYR A 510 O PHE B 549 ? O PHE A 522 AA8 1 2 N PHE B 496 ? N PHE A 469 O VAL B 504 ? O VAL A 477 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software B GD3 601 ? 2 'binding site for residue GD3 B 601' AC2 Software B MG 602 ? 2 'binding site for residue MG B 602' AC3 Software B MG 603 ? 4 'binding site for residue MG B 603' AC4 Software B BCT 604 ? 7 'binding site for residue BCT B 604' AC5 Software B CL 605 ? 3 'binding site for residue CL B 605' AC6 Software B TCR 609 ? 10 'binding site for residue TCR B 609' AC7 Software A GD3 601 ? 2 'binding site for residue GD3 A 601' AC8 Software A MG 602 ? 5 'binding site for residue MG A 602' AC9 Software A BCT 603 ? 7 'binding site for residue BCT A 603' AD1 Software A CL 604 ? 4 'binding site for residue CL A 604' AD2 Software A TCR 609 ? 8 'binding site for residue TCR A 609' AD3 Software A NAG 605 ? 2 'binding site for Mono-Saccharide NAG A 605 bound to ASN A 261' AD4 Software A NAG 606 ? 2 'binding site for Mono-Saccharide NAG A 606 bound to ASN A 287' AD5 Software A NAG 607 ? 2 'binding site for Mono-Saccharide NAG A 607 bound to ASN A 468' AD6 Software A NAG 608 ? 3 'binding site for Mono-Saccharide NAG A 608 bound to ASN A 488' AD7 Software B NAG 606 ? 3 'binding site for Mono-Saccharide NAG B 606 bound to ASN B 261' AD8 Software B NAG 607 ? 1 'binding site for Mono-Saccharide NAG B 607 bound to ASN B 287' AD9 Software B NAG 608 ? 3 'binding site for Mono-Saccharide NAG B 608 bound to ASN B 468' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 2 GLU A 256 ? GLU B 229 . ? 1_555 ? 2 AC1 2 GLU A 259 ? GLU B 232 . ? 1_555 ? 3 AC2 2 SER A 267 ? SER B 240 . ? 1_555 ? 4 AC2 2 HOH U . ? HOH B 706 . ? 1_555 ? 5 AC3 4 ILE A 108 ? ILE B 81 . ? 1_555 ? 6 AC3 4 ASN A 109 ? ASN B 82 . ? 1_555 ? 7 AC3 4 LEU A 114 ? LEU B 87 . ? 1_555 ? 8 AC3 4 LEU A 115 ? LEU B 88 . ? 1_555 ? 9 AC4 7 ARG A 93 ? ARG B 66 . ? 1_555 ? 10 AC4 7 ARG A 96 ? ARG B 69 . ? 1_555 ? 11 AC4 7 TRP A 97 ? TRP B 70 . ? 1_555 ? 12 AC4 7 LEU A 441 ? LEU B 414 . ? 1_555 ? 13 AC4 7 ARG A 442 ? ARG B 415 . ? 1_555 ? 14 AC4 7 ILE A 443 ? ILE B 416 . ? 1_555 ? 15 AC4 7 SER A 444 ? SER B 417 . ? 1_555 ? 16 AC5 3 PRO A 66 ? PRO B 39 . ? 1_555 ? 17 AC5 3 THR A 127 ? THR B 100 . ? 1_555 ? 18 AC5 3 THR A 172 ? THR B 145 . ? 1_555 ? 19 AC6 10 ARG A 93 ? ARG B 66 . ? 1_555 ? 20 AC6 10 TRP A 97 ? TRP B 70 . ? 1_555 ? 21 AC6 10 THR A 172 ? THR B 145 . ? 1_555 ? 22 AC6 10 GLY A 173 ? GLY B 146 . ? 1_555 ? 23 AC6 10 SER A 174 ? SER B 147 . ? 1_555 ? 24 AC6 10 ALA A 195 ? ALA B 168 . ? 1_555 ? 25 AC6 10 SER A 196 ? SER B 169 . ? 1_555 ? 26 AC6 10 SER A 197 ? SER B 170 . ? 1_555 ? 27 AC6 10 TYR A 245 ? TYR B 218 . ? 1_555 ? 28 AC6 10 GLU A 324 ? GLU B 297 . ? 1_555 ? 29 AC7 2 GLU B 256 ? GLU A 229 . ? 1_555 ? 30 AC7 2 GLU B 259 ? GLU A 232 . ? 1_555 ? 31 AC8 5 ILE B 108 ? ILE A 81 . ? 1_555 ? 32 AC8 5 ASN B 109 ? ASN A 82 . ? 1_555 ? 33 AC8 5 SER B 111 ? SER A 84 . ? 1_555 ? 34 AC8 5 LEU B 114 ? LEU A 87 . ? 1_555 ? 35 AC8 5 LEU B 115 ? LEU A 88 . ? 1_555 ? 36 AC9 7 ARG B 93 ? ARG A 66 . ? 1_555 ? 37 AC9 7 ARG B 96 ? ARG A 69 . ? 1_555 ? 38 AC9 7 TRP B 97 ? TRP A 70 . ? 1_555 ? 39 AC9 7 LEU B 441 ? LEU A 414 . ? 1_555 ? 40 AC9 7 ARG B 442 ? ARG A 415 . ? 1_555 ? 41 AC9 7 ILE B 443 ? ILE A 416 . ? 1_555 ? 42 AC9 7 SER B 444 ? SER A 417 . ? 1_555 ? 43 AD1 4 PRO B 66 ? PRO A 39 . ? 1_555 ? 44 AD1 4 THR B 127 ? THR A 100 . ? 1_555 ? 45 AD1 4 ALA B 171 ? ALA A 144 . ? 1_555 ? 46 AD1 4 THR B 172 ? THR A 145 . ? 1_555 ? 47 AD2 8 TRP B 97 ? TRP A 70 . ? 1_555 ? 48 AD2 8 GLY B 173 ? GLY A 146 . ? 1_555 ? 49 AD2 8 SER B 174 ? SER A 147 . ? 1_555 ? 50 AD2 8 ALA B 195 ? ALA A 168 . ? 1_555 ? 51 AD2 8 SER B 196 ? SER A 169 . ? 1_555 ? 52 AD2 8 SER B 197 ? SER A 170 . ? 1_555 ? 53 AD2 8 TYR B 245 ? TYR A 218 . ? 1_555 ? 54 AD2 8 GLU B 324 ? GLU A 297 . ? 1_555 ? 55 AD3 2 GLU B 284 ? GLU A 257 . ? 1_555 ? 56 AD3 2 ASN B 288 ? ASN A 261 . ? 1_555 ? 57 AD4 2 ASN B 314 ? ASN A 287 . ? 1_555 ? 58 AD4 2 ARG B 419 ? ARG A 392 . ? 2_556 ? 59 AD5 2 ASN B 495 ? ASN A 468 . ? 1_555 ? 60 AD5 2 THR B 505 ? THR A 478 . ? 1_555 ? 61 AD6 3 ASN B 515 ? ASN A 488 . ? 1_555 ? 62 AD6 3 ASN B 539 ? ASN A 512 . ? 1_555 ? 63 AD6 3 TYR B 541 ? TYR A 514 . ? 1_555 ? 64 AD7 3 HIS A 281 ? HIS B 254 . ? 1_555 ? 65 AD7 3 GLU A 284 ? GLU B 257 . ? 1_555 ? 66 AD7 3 ASN A 288 ? ASN B 261 . ? 1_555 ? 67 AD8 1 ASN A 314 ? ASN B 287 . ? 1_555 ? 68 AD9 3 ASP A 460 ? ASP B 433 . ? 2_556 ? 69 AD9 3 LEU A 470 ? LEU B 443 . ? 2_556 ? 70 AD9 3 ASN A 495 ? ASN B 468 . ? 1_555 ? # _atom_sites.entry_id 5FBH _atom_sites.fract_transf_matrix[1][1] 0.005810 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.001573 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.012033 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.010967 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C CL GD MG N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . GLY A 1 48 ? -17.410 -22.050 8.456 1.00 90.33 ? 21 GLY B N 1 ATOM 2 C CA . GLY A 1 48 ? -18.706 -22.679 8.884 1.00 96.68 ? 21 GLY B CA 1 ATOM 3 C C . GLY A 1 48 ? -19.944 -22.187 8.126 1.00 96.25 ? 21 GLY B C 1 ATOM 4 O O . GLY A 1 48 ? -19.913 -22.091 6.906 1.00 110.49 ? 21 GLY B O 1 ATOM 5 N N . PRO A 1 49 ? -21.057 -21.913 8.843 1.00 91.97 ? 22 PRO B N 1 ATOM 6 C CA . PRO A 1 49 ? -22.294 -21.355 8.258 1.00 94.21 ? 22 PRO B CA 1 ATOM 7 C C . PRO A 1 49 ? -22.188 -19.961 7.621 1.00 94.92 ? 22 PRO B C 1 ATOM 8 O O . PRO A 1 49 ? -21.302 -19.166 7.966 1.00 92.17 ? 22 PRO B O 1 ATOM 9 C CB . PRO A 1 49 ? -23.250 -21.318 9.454 1.00 87.16 ? 22 PRO B CB 1 ATOM 10 C CG . PRO A 1 49 ? -22.832 -22.482 10.267 1.00 88.37 ? 22 PRO B CG 1 ATOM 11 C CD . PRO A 1 49 ? -21.330 -22.515 10.163 1.00 91.52 ? 22 PRO B CD 1 ATOM 12 N N . ASP A 1 50 ? -23.120 -19.675 6.715 1.00 91.82 ? 23 ASP B N 1 ATOM 13 C CA . ASP A 1 50 ? -23.056 -18.464 5.900 1.00 96.77 ? 23 ASP B CA 1 ATOM 14 C C . ASP A 1 50 ? -23.404 -17.182 6.661 1.00 84.43 ? 23 ASP B C 1 ATOM 15 O O . ASP A 1 50 ? -22.661 -16.206 6.590 1.00 86.73 ? 23 ASP B O 1 ATOM 16 C CB . ASP A 1 50 ? -23.931 -18.620 4.645 1.00 106.13 ? 23 ASP B CB 1 ATOM 17 C CG . ASP A 1 50 ? -23.294 -19.546 3.596 1.00 110.78 ? 23 ASP B CG 1 ATOM 18 O OD1 . ASP A 1 50 ? -22.048 -19.645 3.565 1.00 109.12 ? 23 ASP B OD1 1 ATOM 19 O OD2 . ASP A 1 50 ? -24.033 -20.167 2.797 1.00 107.71 ? 23 ASP B OD2 1 ATOM 20 N N . GLN A 1 51 ? -24.519 -17.192 7.387 1.00 76.09 ? 24 GLN B N 1 ATOM 21 C CA . GLN A 1 51 ? -24.957 -16.029 8.167 1.00 73.30 ? 24 GLN B CA 1 ATOM 22 C C . GLN A 1 51 ? -24.303 -16.053 9.571 1.00 67.48 ? 24 GLN B C 1 ATOM 23 O O . GLN A 1 51 ? -24.358 -17.064 10.264 1.00 71.12 ? 24 GLN B O 1 ATOM 24 C CB . GLN A 1 51 ? -26.483 -16.041 8.269 1.00 77.42 ? 24 GLN B CB 1 ATOM 25 C CG . GLN A 1 51 ? -27.138 -14.670 8.401 1.00 82.26 ? 24 GLN B CG 1 ATOM 26 C CD . GLN A 1 51 ? -28.632 -14.762 8.750 1.00 87.16 ? 24 GLN B CD 1 ATOM 27 O OE1 . GLN A 1 51 ? -29.134 -15.823 9.156 1.00 81.64 ? 24 GLN B OE1 1 ATOM 28 N NE2 . GLN A 1 51 ? -29.345 -13.637 8.621 1.00 84.51 ? 24 GLN B NE2 1 ATOM 29 N N . ARG A 1 52 ? -23.672 -14.953 9.976 1.00 57.52 ? 25 ARG B N 1 ATOM 30 C CA . ARG A 1 52 ? -22.922 -14.915 11.209 1.00 57.24 ? 25 ARG B CA 1 ATOM 31 C C . ARG A 1 52 ? -22.632 -13.514 11.698 1.00 54.44 ? 25 ARG B C 1 ATOM 32 O O . ARG A 1 52 ? -22.989 -12.553 11.068 1.00 60.27 ? 25 ARG B O 1 ATOM 33 C CB . ARG A 1 52 ? -21.610 -15.620 11.008 1.00 59.58 ? 25 ARG B CB 1 ATOM 34 C CG . ARG A 1 52 ? -20.785 -14.980 9.931 1.00 67.38 ? 25 ARG B CG 1 ATOM 35 C CD . ARG A 1 52 ? -19.447 -15.677 9.838 1.00 73.99 ? 25 ARG B CD 1 ATOM 36 N NE . ARG A 1 52 ? -19.596 -17.065 9.412 1.00 78.85 ? 25 ARG B NE 1 ATOM 37 C CZ . ARG A 1 52 ? -18.683 -18.016 9.604 1.00 83.92 ? 25 ARG B CZ 1 ATOM 38 N NH1 . ARG A 1 52 ? -17.528 -17.744 10.225 1.00 79.43 ? 25 ARG B NH1 1 ATOM 39 N NH2 . ARG A 1 52 ? -18.922 -19.254 9.173 1.00 83.06 ? 25 ARG B NH2 1 ATOM 40 N N . ALA A 1 53 ? -22.031 -13.435 12.872 1.00 54.65 ? 26 ALA B N 1 ATOM 41 C CA . ALA A 1 53 ? -21.464 -12.216 13.428 1.00 55.31 ? 26 ALA B CA 1 ATOM 42 C C . ALA A 1 53 ? -20.095 -12.628 13.862 1.00 57.30 ? 26 ALA B C 1 ATOM 43 O O . ALA A 1 53 ? -19.939 -13.620 14.562 1.00 57.93 ? 26 ALA B O 1 ATOM 44 C CB . ALA A 1 53 ? -22.244 -11.692 14.626 1.00 53.13 ? 26 ALA B CB 1 ATOM 45 N N . GLN A 1 54 ? -19.103 -11.864 13.437 1.00 64.98 ? 27 GLN B N 1 ATOM 46 C CA . GLN A 1 54 ? -17.732 -12.301 13.520 1.00 67.18 ? 27 GLN B CA 1 ATOM 47 C C . GLN A 1 54 ? -16.789 -11.116 13.492 1.00 68.16 ? 27 GLN B C 1 ATOM 48 O O . GLN A 1 54 ? -16.968 -10.177 12.724 1.00 61.50 ? 27 GLN B O 1 ATOM 49 C CB . GLN A 1 54 ? -17.429 -13.260 12.385 1.00 69.98 ? 27 GLN B CB 1 ATOM 50 C CG . GLN A 1 54 ? -15.953 -13.481 12.162 1.00 80.07 ? 27 GLN B CG 1 ATOM 51 C CD . GLN A 1 54 ? -15.653 -14.875 11.653 1.00 89.89 ? 27 GLN B CD 1 ATOM 52 O OE1 . GLN A 1 54 ? -16.539 -15.579 11.166 1.00 91.25 ? 27 GLN B OE1 1 ATOM 53 N NE2 . GLN A 1 54 ? -14.392 -15.291 11.774 1.00 96.80 ? 27 GLN B NE2 1 ATOM 54 N N . LYS A 1 55 ? -15.806 -11.172 14.383 1.00 74.05 ? 28 LYS B N 1 ATOM 55 C CA . LYS A 1 55 ? -14.790 -10.150 14.506 1.00 78.52 ? 28 LYS B CA 1 ATOM 56 C C . LYS A 1 55 ? -13.516 -10.796 14.978 1.00 70.35 ? 28 LYS B C 1 ATOM 57 O O . LYS A 1 55 ? -13.551 -11.582 15.907 1.00 66.58 ? 28 LYS B O 1 ATOM 58 C CB . LYS A 1 55 ? -15.224 -9.094 15.500 1.00 83.07 ? 28 LYS B CB 1 ATOM 59 C CG . LYS A 1 55 ? -14.186 -8.008 15.693 1.00 92.32 ? 28 LYS B CG 1 ATOM 60 C CD . LYS A 1 55 ? -14.837 -6.739 16.211 1.00 102.15 ? 28 LYS B CD 1 ATOM 61 C CE . LYS A 1 55 ? -13.814 -5.667 16.541 1.00 105.35 ? 28 LYS B CE 1 ATOM 62 N NZ . LYS A 1 55 ? -14.509 -4.382 16.827 1.00 112.00 ? 28 LYS B NZ 1 ATOM 63 N N . LYS A 1 56 ? -12.402 -10.467 14.325 1.00 70.60 ? 29 LYS B N 1 ATOM 64 C CA . LYS A 1 56 ? -11.101 -11.023 14.669 1.00 66.83 ? 29 LYS B CA 1 ATOM 65 C C . LYS A 1 56 ? -10.704 -10.519 16.059 1.00 67.17 ? 29 LYS B C 1 ATOM 66 O O . LYS A 1 56 ? -11.124 -9.414 16.493 1.00 54.78 ? 29 LYS B O 1 ATOM 67 C CB . LYS A 1 56 ? -10.035 -10.625 13.627 1.00 68.22 ? 29 LYS B CB 1 ATOM 68 N N . GLY A 1 57 ? -9.929 -11.355 16.761 1.00 64.46 ? 30 GLY B N 1 ATOM 69 C CA . GLY A 1 57 ? -9.321 -10.993 18.054 1.00 63.02 ? 30 GLY B CA 1 ATOM 70 C C . GLY A 1 57 ? -8.202 -11.956 18.439 1.00 62.65 ? 30 GLY B C 1 ATOM 71 O O . GLY A 1 57 ? -7.851 -12.872 17.677 1.00 52.96 ? 30 GLY B O 1 ATOM 72 N N . ASP A 1 58 ? -7.631 -11.759 19.623 1.00 65.94 ? 31 ASP B N 1 ATOM 73 C CA . ASP A 1 58 ? -6.578 -12.667 20.110 1.00 65.53 ? 31 ASP B CA 1 ATOM 74 C C . ASP A 1 58 ? -7.163 -13.898 20.720 1.00 69.34 ? 31 ASP B C 1 ATOM 75 O O . ASP A 1 58 ? -6.535 -14.947 20.684 1.00 74.87 ? 31 ASP B O 1 ATOM 76 C CB . ASP A 1 58 ? -5.755 -12.005 21.187 1.00 69.67 ? 31 ASP B CB 1 ATOM 77 C CG . ASP A 1 58 ? -5.123 -10.753 20.719 1.00 68.53 ? 31 ASP B CG 1 ATOM 78 O OD1 . ASP A 1 58 ? -4.332 -10.844 19.750 1.00 68.34 ? 31 ASP B OD1 1 ATOM 79 O OD2 . ASP A 1 58 ? -5.436 -9.700 21.315 1.00 67.88 ? 31 ASP B OD2 1 ATOM 80 N N . ILE A 1 59 ? -8.335 -13.746 21.344 1.00 67.61 ? 32 ILE B N 1 ATOM 81 C CA . ILE A 1 59 ? -9.069 -14.862 21.924 1.00 68.29 ? 32 ILE B CA 1 ATOM 82 C C . ILE A 1 59 ? -10.510 -14.836 21.458 1.00 60.31 ? 32 ILE B C 1 ATOM 83 O O . ILE A 1 59 ? -11.187 -13.828 21.614 1.00 57.95 ? 32 ILE B O 1 ATOM 84 C CB . ILE A 1 59 ? -9.037 -14.792 23.456 1.00 72.95 ? 32 ILE B CB 1 ATOM 85 C CG1 . ILE A 1 59 ? -7.625 -15.088 23.952 1.00 79.99 ? 32 ILE B CG1 1 ATOM 86 C CG2 . ILE A 1 59 ? -9.983 -15.809 24.057 1.00 72.74 ? 32 ILE B CG2 1 ATOM 87 C CD1 . ILE A 1 59 ? -7.370 -14.598 25.354 1.00 81.96 ? 32 ILE B CD1 1 ATOM 88 N N . ILE A 1 60 ? -10.989 -15.946 20.900 1.00 61.23 ? 33 ILE B N 1 ATOM 89 C CA . ILE A 1 60 ? -12.356 -15.957 20.367 1.00 59.85 ? 33 ILE B CA 1 ATOM 90 C C . ILE A 1 60 ? -13.358 -16.620 21.293 1.00 56.78 ? 33 ILE B C 1 ATOM 91 O O . ILE A 1 60 ? -13.130 -17.744 21.802 1.00 50.96 ? 33 ILE B O 1 ATOM 92 C CB . ILE A 1 60 ? -12.484 -16.652 18.987 1.00 62.80 ? 33 ILE B CB 1 ATOM 93 C CG1 . ILE A 1 60 ? -11.407 -16.163 18.008 1.00 59.53 ? 33 ILE B CG1 1 ATOM 94 C CG2 . ILE A 1 60 ? -13.882 -16.391 18.416 1.00 63.10 ? 33 ILE B CG2 1 ATOM 95 C CD1 . ILE A 1 60 ? -11.256 -14.656 18.011 1.00 59.07 ? 33 ILE B CD1 1 ATOM 96 N N . LEU A 1 61 ? -14.475 -15.910 21.478 1.00 49.36 ? 34 LEU B N 1 ATOM 97 C CA . LEU A 1 61 ? -15.654 -16.486 22.050 1.00 46.50 ? 34 LEU B CA 1 ATOM 98 C C . LEU A 1 61 ? -16.670 -16.932 20.982 1.00 47.10 ? 34 LEU B C 1 ATOM 99 O O . LEU A 1 61 ? -17.166 -16.112 20.249 1.00 43.82 ? 34 LEU B O 1 ATOM 100 C CB . LEU A 1 61 ? -16.340 -15.477 22.928 1.00 45.16 ? 34 LEU B CB 1 ATOM 101 C CG . LEU A 1 61 ? -15.599 -14.895 24.120 1.00 49.69 ? 34 LEU B CG 1 ATOM 102 C CD1 . LEU A 1 61 ? -16.586 -14.727 25.262 1.00 51.04 ? 34 LEU B CD1 1 ATOM 103 C CD2 . LEU A 1 61 ? -14.420 -15.705 24.595 1.00 55.92 ? 34 LEU B CD2 1 ATOM 104 N N . GLY A 1 62 ? -17.015 -18.219 20.958 1.00 46.54 ? 35 GLY B N 1 ATOM 105 C CA . GLY A 1 62 ? -18.229 -18.705 20.291 1.00 45.66 ? 35 GLY B CA 1 ATOM 106 C C . GLY A 1 62 ? -19.513 -18.202 20.947 1.00 50.36 ? 35 GLY B C 1 ATOM 107 O O . GLY A 1 62 ? -19.502 -17.737 22.100 1.00 50.76 ? 35 GLY B O 1 ATOM 108 N N . GLY A 1 63 ? -20.603 -18.250 20.172 1.00 52.45 ? 36 GLY B N 1 ATOM 109 C CA . GLY A 1 63 ? -21.959 -17.859 20.591 1.00 51.43 ? 36 GLY B CA 1 ATOM 110 C C . GLY A 1 63 ? -23.029 -18.600 19.752 1.00 49.21 ? 36 GLY B C 1 ATOM 111 O O . GLY A 1 63 ? -22.820 -18.901 18.571 1.00 44.85 ? 36 GLY B O 1 ATOM 112 N N . LEU A 1 64 ? -24.158 -18.922 20.381 1.00 42.77 ? 37 LEU B N 1 ATOM 113 C CA . LEU A 1 64 ? -25.286 -19.562 19.727 1.00 40.97 ? 37 LEU B CA 1 ATOM 114 C C . LEU A 1 64 ? -26.541 -18.839 20.182 1.00 42.69 ? 37 LEU B C 1 ATOM 115 O O . LEU A 1 64 ? -26.771 -18.700 21.376 1.00 39.00 ? 37 LEU B O 1 ATOM 116 C CB . LEU A 1 64 ? -25.360 -21.027 20.101 1.00 38.25 ? 37 LEU B CB 1 ATOM 117 C CG . LEU A 1 64 ? -24.154 -21.805 19.618 1.00 40.88 ? 37 LEU B CG 1 ATOM 118 C CD1 . LEU A 1 64 ? -24.207 -23.187 20.230 1.00 41.06 ? 37 LEU B CD1 1 ATOM 119 C CD2 . LEU A 1 64 ? -24.125 -21.883 18.087 1.00 42.53 ? 37 LEU B CD2 1 ATOM 120 N N . PHE A 1 65 ? -27.335 -18.340 19.238 1.00 44.71 ? 38 PHE B N 1 ATOM 121 C CA . PHE A 1 65 ? -28.574 -17.648 19.582 1.00 44.63 ? 38 PHE B CA 1 ATOM 122 C C . PHE A 1 65 ? -29.682 -18.053 18.619 1.00 44.84 ? 38 PHE B C 1 ATOM 123 O O . PHE A 1 65 ? -29.386 -18.446 17.491 1.00 40.57 ? 38 PHE B O 1 ATOM 124 C CB . PHE A 1 65 ? -28.364 -16.146 19.551 1.00 45.18 ? 38 PHE B CB 1 ATOM 125 C CG . PHE A 1 65 ? -27.400 -15.660 20.583 1.00 44.67 ? 38 PHE B CG 1 ATOM 126 C CD1 . PHE A 1 65 ? -26.036 -15.687 20.335 1.00 44.90 ? 38 PHE B CD1 1 ATOM 127 C CD2 . PHE A 1 65 ? -27.859 -15.194 21.810 1.00 44.10 ? 38 PHE B CD2 1 ATOM 128 C CE1 . PHE A 1 65 ? -25.141 -15.260 21.286 1.00 42.93 ? 38 PHE B CE1 1 ATOM 129 C CE2 . PHE A 1 65 ? -26.976 -14.763 22.774 1.00 42.83 ? 38 PHE B CE2 1 ATOM 130 C CZ . PHE A 1 65 ? -25.612 -14.811 22.506 1.00 46.46 ? 38 PHE B CZ 1 ATOM 131 N N . PRO A 1 66 ? -30.955 -17.997 19.072 1.00 46.35 ? 39 PRO B N 1 ATOM 132 C CA . PRO A 1 66 ? -32.092 -18.363 18.226 1.00 44.05 ? 39 PRO B CA 1 ATOM 133 C C . PRO A 1 66 ? -32.659 -17.123 17.571 1.00 47.91 ? 39 PRO B C 1 ATOM 134 O O . PRO A 1 66 ? -33.671 -16.540 18.056 1.00 47.65 ? 39 PRO B O 1 ATOM 135 C CB . PRO A 1 66 ? -33.081 -18.966 19.221 1.00 44.48 ? 39 PRO B CB 1 ATOM 136 C CG . PRO A 1 66 ? -32.791 -18.260 20.517 1.00 42.66 ? 39 PRO B CG 1 ATOM 137 C CD . PRO A 1 66 ? -31.388 -17.731 20.460 1.00 44.91 ? 39 PRO B CD 1 ATOM 138 N N . ILE A 1 67 ? -31.989 -16.724 16.481 1.00 46.96 ? 40 ILE B N 1 ATOM 139 C CA . ILE A 1 67 ? -32.389 -15.560 15.691 1.00 49.12 ? 40 ILE B CA 1 ATOM 140 C C . ILE A 1 67 ? -33.682 -15.843 14.903 1.00 53.28 ? 40 ILE B C 1 ATOM 141 O O . ILE A 1 67 ? -34.468 -14.927 14.650 1.00 56.45 ? 40 ILE B O 1 ATOM 142 C CB . ILE A 1 67 ? -31.298 -15.131 14.716 1.00 48.98 ? 40 ILE B CB 1 ATOM 143 C CG1 . ILE A 1 67 ? -29.929 -15.020 15.414 1.00 50.61 ? 40 ILE B CG1 1 ATOM 144 C CG2 . ILE A 1 67 ? -31.682 -13.813 14.078 1.00 51.82 ? 40 ILE B CG2 1 ATOM 145 C CD1 . ILE A 1 67 ? -29.881 -14.170 16.671 1.00 47.49 ? 40 ILE B CD1 1 ATOM 146 N N . HIS A 1 68 ? -33.899 -17.103 14.522 1.00 49.34 ? 41 HIS B N 1 ATOM 147 C CA . HIS A 1 68 ? -35.209 -17.534 14.102 1.00 51.28 ? 41 HIS B CA 1 ATOM 148 C C . HIS A 1 68 ? -35.832 -18.489 15.086 1.00 52.21 ? 41 HIS B C 1 ATOM 149 O O . HIS A 1 68 ? -35.127 -19.153 15.814 1.00 49.34 ? 41 HIS B O 1 ATOM 150 C CB . HIS A 1 68 ? -35.092 -18.176 12.754 1.00 55.24 ? 41 HIS B CB 1 ATOM 151 C CG . HIS A 1 68 ? -34.663 -17.211 11.711 1.00 56.62 ? 41 HIS B CG 1 ATOM 152 N ND1 . HIS A 1 68 ? -33.338 -16.919 11.490 1.00 57.38 ? 41 HIS B ND1 1 ATOM 153 C CD2 . HIS A 1 68 ? -35.378 -16.407 10.888 1.00 51.46 ? 41 HIS B CD2 1 ATOM 154 C CE1 . HIS A 1 68 ? -33.249 -16.012 10.537 1.00 58.03 ? 41 HIS B CE1 1 ATOM 155 N NE2 . HIS A 1 68 ? -34.471 -15.684 10.157 1.00 57.92 ? 41 HIS B NE2 1 ATOM 156 N N . PHE A 1 69 ? -37.163 -18.555 15.113 1.00 51.94 ? 42 PHE B N 1 ATOM 157 C CA . PHE A 1 69 ? -37.842 -19.465 16.038 1.00 50.60 ? 42 PHE B CA 1 ATOM 158 C C . PHE A 1 69 ? -37.871 -20.895 15.525 1.00 52.55 ? 42 PHE B C 1 ATOM 159 O O . PHE A 1 69 ? -38.310 -21.787 16.219 1.00 57.28 ? 42 PHE B O 1 ATOM 160 C CB . PHE A 1 69 ? -39.273 -19.039 16.264 1.00 48.47 ? 42 PHE B CB 1 ATOM 161 C CG . PHE A 1 69 ? -39.445 -17.827 17.141 1.00 49.46 ? 42 PHE B CG 1 ATOM 162 C CD1 . PHE A 1 69 ? -39.170 -17.881 18.487 1.00 49.00 ? 42 PHE B CD1 1 ATOM 163 C CD2 . PHE A 1 69 ? -39.975 -16.661 16.630 1.00 52.84 ? 42 PHE B CD2 1 ATOM 164 C CE1 . PHE A 1 69 ? -39.355 -16.786 19.310 1.00 47.67 ? 42 PHE B CE1 1 ATOM 165 C CE2 . PHE A 1 69 ? -40.194 -15.566 17.450 1.00 56.67 ? 42 PHE B CE2 1 ATOM 166 C CZ . PHE A 1 69 ? -39.886 -15.635 18.802 1.00 54.11 ? 42 PHE B CZ 1 ATOM 167 N N . GLY A 1 70 ? -37.456 -21.135 14.294 1.00 55.67 ? 43 GLY B N 1 ATOM 168 C CA . GLY A 1 70 ? -37.663 -22.461 13.730 1.00 57.41 ? 43 GLY B CA 1 ATOM 169 C C . GLY A 1 70 ? -37.177 -22.670 12.318 1.00 54.32 ? 43 GLY B C 1 ATOM 170 O O . GLY A 1 70 ? -36.806 -21.747 11.641 1.00 53.54 ? 43 GLY B O 1 ATOM 171 N N . VAL A 1 71 ? -37.193 -23.912 11.879 1.00 63.74 ? 44 VAL B N 1 ATOM 172 C CA . VAL A 1 71 ? -36.821 -24.235 10.522 1.00 71.99 ? 44 VAL B CA 1 ATOM 173 C C . VAL A 1 71 ? -38.076 -24.437 9.672 1.00 78.10 ? 44 VAL B C 1 ATOM 174 O O . VAL A 1 71 ? -39.141 -24.791 10.186 1.00 75.94 ? 44 VAL B O 1 ATOM 175 C CB . VAL A 1 71 ? -35.920 -25.467 10.540 1.00 78.68 ? 44 VAL B CB 1 ATOM 176 C CG1 . VAL A 1 71 ? -35.924 -26.204 9.212 1.00 92.48 ? 44 VAL B CG1 1 ATOM 177 C CG2 . VAL A 1 71 ? -34.514 -25.030 10.905 1.00 81.22 ? 44 VAL B CG2 1 ATOM 178 N N . ALA A 1 72 ? -37.944 -24.176 8.375 1.00 88.39 ? 45 ALA B N 1 ATOM 179 C CA . ALA A 1 72 ? -39.009 -24.437 7.407 1.00 96.02 ? 45 ALA B CA 1 ATOM 180 C C . ALA A 1 72 ? -39.206 -25.943 7.247 1.00 103.15 ? 45 ALA B C 1 ATOM 181 O O . ALA A 1 72 ? -38.275 -26.652 6.841 1.00 99.96 ? 45 ALA B O 1 ATOM 182 C CB . ALA A 1 72 ? -38.657 -23.808 6.073 1.00 95.58 ? 45 ALA B CB 1 ATOM 183 N N . ALA A 1 73 ? -40.412 -26.425 7.558 1.00 116.80 ? 46 ALA B N 1 ATOM 184 C CA . ALA A 1 73 ? -40.684 -27.870 7.629 1.00 129.79 ? 46 ALA B CA 1 ATOM 185 C C . ALA A 1 73 ? -41.188 -28.451 6.302 1.00 127.66 ? 46 ALA B C 1 ATOM 186 O O . ALA A 1 73 ? -42.249 -29.074 6.252 1.00 128.10 ? 46 ALA B O 1 ATOM 187 C CB . ALA A 1 73 ? -41.664 -28.178 8.765 1.00 126.88 ? 46 ALA B CB 1 ATOM 188 N N . LYS A 1 74 ? -40.417 -28.248 5.234 1.00 121.55 ? 47 LYS B N 1 ATOM 189 C CA . LYS A 1 74 ? -40.620 -28.968 3.986 1.00 120.97 ? 47 LYS B CA 1 ATOM 190 C C . LYS A 1 74 ? -40.051 -30.366 4.199 1.00 125.65 ? 47 LYS B C 1 ATOM 191 O O . LYS A 1 74 ? -38.929 -30.653 3.763 1.00 131.77 ? 47 LYS B O 1 ATOM 192 C CB . LYS A 1 74 ? -39.908 -28.259 2.828 1.00 117.49 ? 47 LYS B CB 1 ATOM 193 N N . ASP A 1 75 ? -40.829 -31.220 4.879 1.00 125.84 ? 48 ASP B N 1 ATOM 194 C CA . ASP A 1 75 ? -40.354 -32.531 5.369 1.00 124.59 ? 48 ASP B CA 1 ATOM 195 C C . ASP A 1 75 ? -39.846 -33.405 4.223 1.00 121.64 ? 48 ASP B C 1 ATOM 196 O O . ASP A 1 75 ? -40.604 -33.757 3.313 1.00 115.74 ? 48 ASP B O 1 ATOM 197 C CB . ASP A 1 75 ? -41.451 -33.261 6.162 1.00 114.93 ? 48 ASP B CB 1 ATOM 198 N N . GLN A 1 76 ? -38.553 -33.734 4.274 1.00 121.70 ? 49 GLN B N 1 ATOM 199 C CA . GLN A 1 76 ? -37.869 -34.386 3.154 1.00 113.88 ? 49 GLN B CA 1 ATOM 200 C C . GLN A 1 76 ? -38.267 -35.840 2.962 1.00 107.14 ? 49 GLN B C 1 ATOM 201 O O . GLN A 1 76 ? -38.061 -36.703 3.819 1.00 90.84 ? 49 GLN B O 1 ATOM 202 C CB . GLN A 1 76 ? -36.352 -34.277 3.287 1.00 110.95 ? 49 GLN B CB 1 ATOM 203 C CG . GLN A 1 76 ? -35.803 -33.005 2.664 1.00 121.01 ? 49 GLN B CG 1 ATOM 204 C CD . GLN A 1 76 ? -34.807 -32.297 3.551 1.00 119.75 ? 49 GLN B CD 1 ATOM 205 O OE1 . GLN A 1 76 ? -34.731 -32.560 4.760 1.00 113.07 ? 49 GLN B OE1 1 ATOM 206 N NE2 . GLN A 1 76 ? -34.042 -31.376 2.959 1.00 113.20 ? 49 GLN B NE2 1 ATOM 207 N N . ASP A 1 77 ? -38.845 -36.088 1.799 1.00 100.51 ? 50 ASP B N 1 ATOM 208 C CA . ASP A 1 77 ? -39.098 -37.427 1.344 1.00 89.09 ? 50 ASP B CA 1 ATOM 209 C C . ASP A 1 77 ? -37.828 -37.989 0.683 1.00 79.47 ? 50 ASP B C 1 ATOM 210 O O . ASP A 1 77 ? -37.805 -39.144 0.291 1.00 81.53 ? 50 ASP B O 1 ATOM 211 C CB . ASP A 1 77 ? -40.314 -37.439 0.410 1.00 95.56 ? 50 ASP B CB 1 ATOM 212 C CG . ASP A 1 77 ? -40.316 -36.275 -0.590 1.00 101.12 ? 50 ASP B CG 1 ATOM 213 O OD1 . ASP A 1 77 ? -39.242 -35.657 -0.814 1.00 104.87 ? 50 ASP B OD1 1 ATOM 214 O OD2 . ASP A 1 77 ? -41.399 -35.989 -1.154 1.00 96.12 ? 50 ASP B OD2 1 ATOM 215 N N . LEU A 1 78 ? -36.773 -37.174 0.592 1.00 73.79 ? 51 LEU B N 1 ATOM 216 C CA . LEU A 1 78 ? -35.444 -37.592 0.109 1.00 68.86 ? 51 LEU B CA 1 ATOM 217 C C . LEU A 1 78 ? -35.500 -38.103 -1.289 1.00 76.08 ? 51 LEU B C 1 ATOM 218 O O . LEU A 1 78 ? -34.794 -39.071 -1.606 1.00 75.69 ? 51 LEU B O 1 ATOM 219 C CB . LEU A 1 78 ? -34.826 -38.697 0.955 1.00 65.63 ? 51 LEU B CB 1 ATOM 220 C CG . LEU A 1 78 ? -34.432 -38.402 2.383 1.00 63.68 ? 51 LEU B CG 1 ATOM 221 C CD1 . LEU A 1 78 ? -33.974 -39.679 3.066 1.00 62.18 ? 51 LEU B CD1 1 ATOM 222 C CD2 . LEU A 1 78 ? -33.334 -37.359 2.390 1.00 64.74 ? 51 LEU B CD2 1 ATOM 223 N N . LYS A 1 79 ? -36.342 -37.465 -2.109 1.00 83.22 ? 52 LYS B N 1 ATOM 224 C CA . LYS A 1 79 ? -36.471 -37.806 -3.521 1.00 84.66 ? 52 LYS B CA 1 ATOM 225 C C . LYS A 1 79 ? -35.282 -37.289 -4.328 1.00 84.79 ? 52 LYS B C 1 ATOM 226 O O . LYS A 1 79 ? -34.872 -37.926 -5.282 1.00 79.47 ? 52 LYS B O 1 ATOM 227 C CB . LYS A 1 79 ? -37.779 -37.271 -4.089 1.00 94.66 ? 52 LYS B CB 1 ATOM 228 C CG . LYS A 1 79 ? -38.981 -38.166 -3.819 1.00 101.17 ? 52 LYS B CG 1 ATOM 229 C CD . LYS A 1 79 ? -40.153 -37.809 -4.731 1.00 107.99 ? 52 LYS B CD 1 ATOM 230 C CE . LYS A 1 79 ? -40.807 -39.045 -5.355 1.00 108.51 ? 52 LYS B CE 1 ATOM 231 N NZ . LYS A 1 79 ? -41.557 -39.880 -4.371 1.00 101.37 ? 52 LYS B NZ 1 ATOM 232 N N . SER A 1 80 ? -34.734 -36.136 -3.949 1.00 90.28 ? 53 SER B N 1 ATOM 233 C CA . SER A 1 80 ? -33.455 -35.659 -4.511 1.00 96.82 ? 53 SER B CA 1 ATOM 234 C C . SER A 1 80 ? -32.508 -35.414 -3.350 1.00 93.20 ? 53 SER B C 1 ATOM 235 O O . SER A 1 80 ? -32.912 -35.619 -2.203 1.00 93.07 ? 53 SER B O 1 ATOM 236 C CB . SER A 1 80 ? -33.648 -34.377 -5.322 1.00 97.98 ? 53 SER B CB 1 ATOM 237 O OG . SER A 1 80 ? -34.052 -33.296 -4.501 1.00 90.92 ? 53 SER B OG 1 ATOM 238 N N . ARG A 1 81 ? -31.265 -35.003 -3.620 1.00 90.13 ? 54 ARG B N 1 ATOM 239 C CA . ARG A 1 81 ? -30.338 -34.651 -2.526 1.00 93.15 ? 54 ARG B CA 1 ATOM 240 C C . ARG A 1 81 ? -30.979 -33.573 -1.642 1.00 93.13 ? 54 ARG B C 1 ATOM 241 O O . ARG A 1 81 ? -31.549 -32.601 -2.162 1.00 87.24 ? 54 ARG B O 1 ATOM 242 C CB . ARG A 1 81 ? -28.979 -34.166 -3.042 1.00 96.55 ? 54 ARG B CB 1 ATOM 243 C CG . ARG A 1 81 ? -28.134 -33.417 -2.005 1.00 102.23 ? 54 ARG B CG 1 ATOM 244 C CD . ARG A 1 81 ? -26.630 -33.650 -2.155 1.00 108.45 ? 54 ARG B CD 1 ATOM 245 N NE . ARG A 1 81 ? -26.148 -33.481 -3.531 1.00 118.31 ? 54 ARG B NE 1 ATOM 246 C CZ . ARG A 1 81 ? -25.948 -34.466 -4.414 1.00 120.02 ? 54 ARG B CZ 1 ATOM 247 N NH1 . ARG A 1 81 ? -26.183 -35.734 -4.102 1.00 117.94 ? 54 ARG B NH1 1 ATOM 248 N NH2 . ARG A 1 81 ? -25.509 -34.179 -5.633 1.00 126.86 ? 54 ARG B NH2 1 ATOM 249 N N . PRO A 1 82 ? -30.936 -33.768 -0.307 1.00 91.52 ? 55 PRO B N 1 ATOM 250 C CA . PRO A 1 82 ? -31.441 -32.710 0.569 1.00 89.50 ? 55 PRO B CA 1 ATOM 251 C C . PRO A 1 82 ? -30.526 -31.481 0.554 1.00 80.32 ? 55 PRO B C 1 ATOM 252 O O . PRO A 1 82 ? -29.333 -31.600 0.804 1.00 67.83 ? 55 PRO B O 1 ATOM 253 C CB . PRO A 1 82 ? -31.481 -33.356 1.970 1.00 87.71 ? 55 PRO B CB 1 ATOM 254 C CG . PRO A 1 82 ? -30.945 -34.732 1.839 1.00 86.69 ? 55 PRO B CG 1 ATOM 255 C CD . PRO A 1 82 ? -30.507 -34.975 0.429 1.00 89.99 ? 55 PRO B CD 1 ATOM 256 N N . GLU A 1 83 ? -31.090 -30.323 0.227 1.00 85.55 ? 56 GLU B N 1 ATOM 257 C CA . GLU A 1 83 ? -30.419 -29.043 0.450 1.00 89.11 ? 56 GLU B CA 1 ATOM 258 C C . GLU A 1 83 ? -30.458 -28.751 1.956 1.00 90.19 ? 56 GLU B C 1 ATOM 259 O O . GLU A 1 83 ? -31.049 -29.500 2.736 1.00 87.41 ? 56 GLU B O 1 ATOM 260 C CB . GLU A 1 83 ? -31.109 -27.923 -0.349 1.00 81.60 ? 56 GLU B CB 1 ATOM 261 N N . SER A 1 84 ? -29.818 -27.672 2.371 1.00 94.06 ? 57 SER B N 1 ATOM 262 C CA . SER A 1 84 ? -29.881 -27.251 3.765 1.00 98.76 ? 57 SER B CA 1 ATOM 263 C C . SER A 1 84 ? -31.237 -26.580 4.047 1.00 101.37 ? 57 SER B C 1 ATOM 264 O O . SER A 1 84 ? -31.746 -25.835 3.208 1.00 100.16 ? 57 SER B O 1 ATOM 265 C CB . SER A 1 84 ? -28.750 -26.279 4.053 1.00 93.46 ? 57 SER B CB 1 ATOM 266 O OG . SER A 1 84 ? -28.859 -25.186 3.173 1.00 89.30 ? 57 SER B OG 1 ATOM 267 N N . VAL A 1 85 ? -31.820 -26.843 5.220 1.00 97.28 ? 58 VAL B N 1 ATOM 268 C CA . VAL A 1 85 ? -33.112 -26.249 5.583 1.00 94.82 ? 58 VAL B CA 1 ATOM 269 C C . VAL A 1 85 ? -33.013 -24.706 5.706 1.00 89.03 ? 58 VAL B C 1 ATOM 270 O O . VAL A 1 85 ? -31.931 -24.146 5.866 1.00 78.04 ? 58 VAL B O 1 ATOM 271 C CB . VAL A 1 85 ? -33.654 -26.870 6.889 1.00 88.75 ? 58 VAL B CB 1 ATOM 272 N N . GLU A 1 86 ? -34.134 -24.014 5.594 1.00 82.14 ? 59 GLU B N 1 ATOM 273 C CA . GLU A 1 86 ? -34.127 -22.569 5.705 1.00 78.79 ? 59 GLU B CA 1 ATOM 274 C C . GLU A 1 86 ? -34.743 -22.225 7.033 1.00 76.22 ? 59 GLU B C 1 ATOM 275 O O . GLU A 1 86 ? -35.678 -22.905 7.479 1.00 78.94 ? 59 GLU B O 1 ATOM 276 C CB . GLU A 1 86 ? -34.948 -21.934 4.582 1.00 89.53 ? 59 GLU B CB 1 ATOM 277 N N . CYS A 1 87 ? -34.247 -21.160 7.654 1.00 64.56 ? 60 CYS B N 1 ATOM 278 C CA . CYS A 1 87 ? -34.762 -20.751 8.941 1.00 66.05 ? 60 CYS B CA 1 ATOM 279 C C . CYS A 1 87 ? -35.876 -19.759 8.765 1.00 67.75 ? 60 CYS B C 1 ATOM 280 O O . CYS A 1 87 ? -35.794 -18.873 7.915 1.00 67.08 ? 60 CYS B O 1 ATOM 281 C CB . CYS A 1 87 ? -33.648 -20.199 9.821 1.00 73.36 ? 60 CYS B CB 1 ATOM 282 S SG . CYS A 1 87 ? -32.599 -21.570 10.367 1.00 83.60 ? 60 CYS B SG 1 ATOM 283 N N . ILE A 1 88 ? -36.907 -19.905 9.598 1.00 65.80 ? 61 ILE B N 1 ATOM 284 C CA . ILE A 1 88 ? -38.156 -19.192 9.420 1.00 64.73 ? 61 ILE B CA 1 ATOM 285 C C . ILE A 1 88 ? -38.696 -18.555 10.728 1.00 59.01 ? 61 ILE B C 1 ATOM 286 O O . ILE A 1 88 ? -38.495 -19.088 11.811 1.00 57.74 ? 61 ILE B O 1 ATOM 287 C CB . ILE A 1 88 ? -39.166 -20.137 8.718 1.00 73.79 ? 61 ILE B CB 1 ATOM 288 C CG1 . ILE A 1 88 ? -39.960 -19.354 7.686 1.00 83.29 ? 61 ILE B CG1 1 ATOM 289 C CG2 . ILE A 1 88 ? -40.063 -20.897 9.697 1.00 74.39 ? 61 ILE B CG2 1 ATOM 290 C CD1 . ILE A 1 88 ? -39.136 -18.961 6.462 1.00 94.56 ? 61 ILE B CD1 1 ATOM 291 N N . ARG A 1 89 ? -39.339 -17.390 10.587 1.00 56.82 ? 62 ARG B N 1 ATOM 292 C CA . ARG A 1 89 ? -39.906 -16.550 11.668 1.00 51.76 ? 62 ARG B CA 1 ATOM 293 C C . ARG A 1 89 ? -38.888 -15.857 12.549 1.00 49.98 ? 62 ARG B C 1 ATOM 294 O O . ARG A 1 89 ? -38.391 -16.426 13.529 1.00 49.18 ? 62 ARG B O 1 ATOM 295 C CB . ARG A 1 89 ? -40.860 -17.325 12.555 1.00 60.32 ? 62 ARG B CB 1 ATOM 296 C CG . ARG A 1 89 ? -41.863 -18.169 11.813 1.00 68.96 ? 62 ARG B CG 1 ATOM 297 C CD . ARG A 1 89 ? -42.592 -19.066 12.784 1.00 73.21 ? 62 ARG B CD 1 ATOM 298 N NE . ARG A 1 89 ? -43.680 -18.335 13.403 1.00 79.00 ? 62 ARG B NE 1 ATOM 299 C CZ . ARG A 1 89 ? -44.276 -18.684 14.535 1.00 84.88 ? 62 ARG B CZ 1 ATOM 300 N NH1 . ARG A 1 89 ? -43.869 -19.757 15.213 1.00 85.26 ? 62 ARG B NH1 1 ATOM 301 N NH2 . ARG A 1 89 ? -45.288 -17.948 14.987 1.00 79.90 ? 62 ARG B NH2 1 ATOM 302 N N . TYR A 1 90 ? -38.609 -14.604 12.236 1.00 51.71 ? 63 TYR B N 1 ATOM 303 C CA . TYR A 1 90 ? -37.545 -13.880 12.935 1.00 51.94 ? 63 TYR B CA 1 ATOM 304 C C . TYR A 1 90 ? -37.860 -13.772 14.431 1.00 54.58 ? 63 TYR B C 1 ATOM 305 O O . TYR A 1 90 ? -39.013 -13.537 14.803 1.00 58.24 ? 63 TYR B O 1 ATOM 306 C CB . TYR A 1 90 ? -37.335 -12.497 12.314 1.00 49.28 ? 63 TYR B CB 1 ATOM 307 C CG . TYR A 1 90 ? -35.927 -11.951 12.487 1.00 51.55 ? 63 TYR B CG 1 ATOM 308 C CD1 . TYR A 1 90 ? -34.903 -12.372 11.675 1.00 49.29 ? 63 TYR B CD1 1 ATOM 309 C CD2 . TYR A 1 90 ? -35.639 -11.009 13.467 1.00 51.26 ? 63 TYR B CD2 1 ATOM 310 C CE1 . TYR A 1 90 ? -33.635 -11.868 11.828 1.00 55.61 ? 63 TYR B CE1 1 ATOM 311 C CE2 . TYR A 1 90 ? -34.370 -10.508 13.634 1.00 50.38 ? 63 TYR B CE2 1 ATOM 312 C CZ . TYR A 1 90 ? -33.370 -10.940 12.817 1.00 55.29 ? 63 TYR B CZ 1 ATOM 313 O OH . TYR A 1 90 ? -32.087 -10.459 12.981 1.00 62.37 ? 63 TYR B OH 1 ATOM 314 N N . ASN A 1 91 ? -36.845 -13.993 15.272 1.00 51.11 ? 64 ASN B N 1 ATOM 315 C CA . ASN A 1 91 ? -36.938 -13.773 16.728 1.00 52.99 ? 64 ASN B CA 1 ATOM 316 C C . ASN A 1 91 ? -36.215 -12.477 17.167 1.00 56.61 ? 64 ASN B C 1 ATOM 317 O O . ASN A 1 91 ? -35.016 -12.468 17.432 1.00 59.00 ? 64 ASN B O 1 ATOM 318 C CB . ASN A 1 91 ? -36.343 -14.967 17.467 1.00 55.06 ? 64 ASN B CB 1 ATOM 319 C CG . ASN A 1 91 ? -36.522 -14.898 18.988 1.00 54.11 ? 64 ASN B CG 1 ATOM 320 O OD1 . ASN A 1 91 ? -37.215 -14.043 19.535 1.00 47.84 ? 64 ASN B OD1 1 ATOM 321 N ND2 . ASN A 1 91 ? -35.882 -15.832 19.672 1.00 58.15 ? 64 ASN B ND2 1 ATOM 322 N N . PHE A 1 92 ? -36.960 -11.383 17.247 1.00 60.24 ? 65 PHE B N 1 ATOM 323 C CA . PHE A 1 92 ? -36.407 -10.094 17.651 1.00 57.04 ? 65 PHE B CA 1 ATOM 324 C C . PHE A 1 92 ? -35.775 -10.084 19.034 1.00 51.54 ? 65 PHE B C 1 ATOM 325 O O . PHE A 1 92 ? -34.748 -9.482 19.240 1.00 47.97 ? 65 PHE B O 1 ATOM 326 C CB . PHE A 1 92 ? -37.501 -9.044 17.579 1.00 60.21 ? 65 PHE B CB 1 ATOM 327 C CG . PHE A 1 92 ? -37.881 -8.699 16.177 1.00 63.17 ? 65 PHE B CG 1 ATOM 328 C CD1 . PHE A 1 92 ? -36.980 -7.992 15.366 1.00 57.92 ? 65 PHE B CD1 1 ATOM 329 C CD2 . PHE A 1 92 ? -39.111 -9.104 15.653 1.00 58.73 ? 65 PHE B CD2 1 ATOM 330 C CE1 . PHE A 1 92 ? -37.312 -7.690 14.063 1.00 62.50 ? 65 PHE B CE1 1 ATOM 331 C CE2 . PHE A 1 92 ? -39.448 -8.798 14.352 1.00 57.14 ? 65 PHE B CE2 1 ATOM 332 C CZ . PHE A 1 92 ? -38.544 -8.095 13.553 1.00 63.01 ? 65 PHE B CZ 1 ATOM 333 N N . ARG A 1 93 ? -36.391 -10.776 19.970 1.00 50.99 ? 66 ARG B N 1 ATOM 334 C CA . ARG A 1 93 ? -35.834 -10.891 21.291 1.00 49.23 ? 66 ARG B CA 1 ATOM 335 C C . ARG A 1 93 ? -34.497 -11.581 21.208 1.00 49.13 ? 66 ARG B C 1 ATOM 336 O O . ARG A 1 93 ? -33.556 -11.189 21.878 1.00 55.60 ? 66 ARG B O 1 ATOM 337 C CB . ARG A 1 93 ? -36.784 -11.675 22.186 1.00 50.99 ? 66 ARG B CB 1 ATOM 338 C CG . ARG A 1 93 ? -36.489 -11.613 23.660 1.00 53.81 ? 66 ARG B CG 1 ATOM 339 C CD . ARG A 1 93 ? -37.594 -12.350 24.380 1.00 59.18 ? 66 ARG B CD 1 ATOM 340 N NE . ARG A 1 93 ? -37.360 -12.508 25.819 1.00 67.33 ? 66 ARG B NE 1 ATOM 341 C CZ . ARG A 1 93 ? -37.952 -13.427 26.588 1.00 73.88 ? 66 ARG B CZ 1 ATOM 342 N NH1 . ARG A 1 93 ? -38.815 -14.300 26.076 1.00 75.79 ? 66 ARG B NH1 1 ATOM 343 N NH2 . ARG A 1 93 ? -37.670 -13.488 27.886 1.00 80.97 ? 66 ARG B NH2 1 ATOM 344 N N . GLY A 1 94 ? -34.405 -12.603 20.373 1.00 45.55 ? 67 GLY B N 1 ATOM 345 C CA . GLY A 1 94 ? -33.166 -13.369 20.242 1.00 43.25 ? 67 GLY B CA 1 ATOM 346 C C . GLY A 1 94 ? -32.056 -12.550 19.629 1.00 42.96 ? 67 GLY B C 1 ATOM 347 O O . GLY A 1 94 ? -30.898 -12.711 19.942 1.00 50.00 ? 67 GLY B O 1 ATOM 348 N N . PHE A 1 95 ? -32.404 -11.640 18.758 1.00 45.55 ? 68 PHE B N 1 ATOM 349 C CA . PHE A 1 95 ? -31.407 -10.748 18.211 1.00 47.00 ? 68 PHE B CA 1 ATOM 350 C C . PHE A 1 95 ? -30.922 -9.761 19.296 1.00 42.74 ? 68 PHE B C 1 ATOM 351 O O . PHE A 1 95 ? -29.743 -9.412 19.372 1.00 42.00 ? 68 PHE B O 1 ATOM 352 C CB . PHE A 1 95 ? -31.997 -10.018 16.998 1.00 49.41 ? 68 PHE B CB 1 ATOM 353 C CG . PHE A 1 95 ? -31.008 -9.154 16.293 1.00 47.57 ? 68 PHE B CG 1 ATOM 354 C CD1 . PHE A 1 95 ? -30.023 -9.716 15.517 1.00 46.25 ? 68 PHE B CD1 1 ATOM 355 C CD2 . PHE A 1 95 ? -31.049 -7.779 16.441 1.00 45.43 ? 68 PHE B CD2 1 ATOM 356 C CE1 . PHE A 1 95 ? -29.090 -8.914 14.876 1.00 48.85 ? 68 PHE B CE1 1 ATOM 357 C CE2 . PHE A 1 95 ? -30.131 -6.977 15.801 1.00 45.25 ? 68 PHE B CE2 1 ATOM 358 C CZ . PHE A 1 95 ? -29.137 -7.548 15.025 1.00 46.67 ? 68 PHE B CZ 1 ATOM 359 N N . ARG A 1 96 ? -31.834 -9.331 20.151 1.00 38.60 ? 69 ARG B N 1 ATOM 360 C CA . ARG A 1 96 ? -31.440 -8.535 21.280 1.00 39.99 ? 69 ARG B CA 1 ATOM 361 C C . ARG A 1 96 ? -30.497 -9.337 22.169 1.00 40.84 ? 69 ARG B C 1 ATOM 362 O O . ARG A 1 96 ? -29.518 -8.828 22.637 1.00 42.84 ? 69 ARG B O 1 ATOM 363 C CB . ARG A 1 96 ? -32.653 -8.031 22.061 1.00 41.78 ? 69 ARG B CB 1 ATOM 364 C CG . ARG A 1 96 ? -32.240 -7.489 23.398 1.00 46.96 ? 69 ARG B CG 1 ATOM 365 C CD . ARG A 1 96 ? -33.219 -6.514 23.977 1.00 46.59 ? 69 ARG B CD 1 ATOM 366 N NE . ARG A 1 96 ? -34.573 -6.966 23.823 1.00 49.87 ? 69 ARG B NE 1 ATOM 367 C CZ . ARG A 1 96 ? -35.229 -7.768 24.660 1.00 56.68 ? 69 ARG B CZ 1 ATOM 368 N NH1 . ARG A 1 96 ? -34.654 -8.278 25.737 1.00 59.68 ? 69 ARG B NH1 1 ATOM 369 N NH2 . ARG A 1 96 ? -36.498 -8.075 24.410 1.00 59.81 ? 69 ARG B NH2 1 ATOM 370 N N . TRP A 1 97 ? -30.753 -10.617 22.378 1.00 44.46 ? 70 TRP B N 1 ATOM 371 C CA . TRP A 1 97 ? -29.804 -11.407 23.162 1.00 42.47 ? 70 TRP B CA 1 ATOM 372 C C . TRP A 1 97 ? -28.449 -11.425 22.509 1.00 42.83 ? 70 TRP B C 1 ATOM 373 O O . TRP A 1 97 ? -27.446 -11.307 23.181 1.00 44.53 ? 70 TRP B O 1 ATOM 374 C CB . TRP A 1 97 ? -30.293 -12.836 23.339 1.00 39.99 ? 70 TRP B CB 1 ATOM 375 C CG . TRP A 1 97 ? -31.498 -12.886 24.071 1.00 38.95 ? 70 TRP B CG 1 ATOM 376 C CD1 . TRP A 1 97 ? -32.086 -11.854 24.770 1.00 38.28 ? 70 TRP B CD1 1 ATOM 377 C CD2 . TRP A 1 97 ? -32.327 -14.025 24.248 1.00 39.44 ? 70 TRP B CD2 1 ATOM 378 N NE1 . TRP A 1 97 ? -33.257 -12.283 25.309 1.00 40.68 ? 70 TRP B NE1 1 ATOM 379 C CE2 . TRP A 1 97 ? -33.427 -13.618 25.018 1.00 40.00 ? 70 TRP B CE2 1 ATOM 380 C CE3 . TRP A 1 97 ? -32.264 -15.345 23.800 1.00 40.53 ? 70 TRP B CE3 1 ATOM 381 C CZ2 . TRP A 1 97 ? -34.449 -14.492 25.369 1.00 38.56 ? 70 TRP B CZ2 1 ATOM 382 C CZ3 . TRP A 1 97 ? -33.261 -16.200 24.139 1.00 37.25 ? 70 TRP B CZ3 1 ATOM 383 C CH2 . TRP A 1 97 ? -34.352 -15.770 24.916 1.00 40.49 ? 70 TRP B CH2 1 ATOM 384 N N . LEU A 1 98 ? -28.409 -11.599 21.199 1.00 42.38 ? 71 LEU B N 1 ATOM 385 C CA . LEU A 1 98 ? -27.126 -11.667 20.540 1.00 46.00 ? 71 LEU B CA 1 ATOM 386 C C . LEU A 1 98 ? -26.458 -10.308 20.693 1.00 46.48 ? 71 LEU B C 1 ATOM 387 O O . LEU A 1 98 ? -25.244 -10.250 20.856 1.00 45.30 ? 71 LEU B O 1 ATOM 388 C CB . LEU A 1 98 ? -27.254 -12.110 19.067 1.00 46.68 ? 71 LEU B CB 1 ATOM 389 C CG . LEU A 1 98 ? -26.030 -11.923 18.162 1.00 49.71 ? 71 LEU B CG 1 ATOM 390 C CD1 . LEU A 1 98 ? -26.061 -12.806 16.927 1.00 49.63 ? 71 LEU B CD1 1 ATOM 391 C CD2 . LEU A 1 98 ? -25.948 -10.488 17.717 1.00 48.91 ? 71 LEU B CD2 1 ATOM 392 N N . GLN A 1 99 ? -27.232 -9.219 20.673 1.00 45.68 ? 72 GLN B N 1 ATOM 393 C CA . GLN A 1 99 ? -26.597 -7.897 20.766 1.00 51.68 ? 72 GLN B CA 1 ATOM 394 C C . GLN A 1 99 ? -25.869 -7.728 22.072 1.00 54.29 ? 72 GLN B C 1 ATOM 395 O O . GLN A 1 99 ? -24.751 -7.188 22.094 1.00 53.59 ? 72 GLN B O 1 ATOM 396 C CB . GLN A 1 99 ? -27.578 -6.754 20.607 1.00 53.81 ? 72 GLN B CB 1 ATOM 397 C CG . GLN A 1 99 ? -28.065 -6.553 19.193 1.00 57.49 ? 72 GLN B CG 1 ATOM 398 C CD . GLN A 1 99 ? -27.094 -5.781 18.327 1.00 56.81 ? 72 GLN B CD 1 ATOM 399 O OE1 . GLN A 1 99 ? -27.441 -4.715 17.799 1.00 62.45 ? 72 GLN B OE1 1 ATOM 400 N NE2 . GLN A 1 99 ? -25.894 -6.321 18.143 1.00 49.30 ? 72 GLN B NE2 1 ATOM 401 N N . ALA A 1 100 ? -26.504 -8.210 23.141 1.00 53.43 ? 73 ALA B N 1 ATOM 402 C CA . ALA A 1 100 ? -25.941 -8.169 24.496 1.00 52.52 ? 73 ALA B CA 1 ATOM 403 C C . ALA A 1 100 ? -24.586 -8.820 24.569 1.00 50.18 ? 73 ALA B C 1 ATOM 404 O O . ALA A 1 100 ? -23.743 -8.348 25.297 1.00 49.93 ? 73 ALA B O 1 ATOM 405 C CB . ALA A 1 100 ? -26.878 -8.817 25.504 1.00 55.16 ? 73 ALA B CB 1 ATOM 406 N N . MET A 1 101 ? -24.361 -9.892 23.823 1.00 48.59 ? 74 MET B N 1 ATOM 407 C CA . MET A 1 101 ? -23.040 -10.514 23.825 1.00 49.89 ? 74 MET B CA 1 ATOM 408 C C . MET A 1 101 ? -22.002 -9.626 23.148 1.00 53.59 ? 74 MET B C 1 ATOM 409 O O . MET A 1 101 ? -20.888 -9.472 23.643 1.00 60.04 ? 74 MET B O 1 ATOM 410 C CB . MET A 1 101 ? -23.072 -11.849 23.101 1.00 48.89 ? 74 MET B CB 1 ATOM 411 C CG . MET A 1 101 ? -21.698 -12.411 22.823 1.00 47.78 ? 74 MET B CG 1 ATOM 412 S SD . MET A 1 101 ? -21.755 -14.177 22.532 1.00 43.31 ? 74 MET B SD 1 ATOM 413 C CE . MET A 1 101 ? -20.034 -14.515 22.162 1.00 43.40 ? 74 MET B CE 1 ATOM 414 N N . ILE A 1 102 ? -22.372 -9.071 22.002 1.00 53.30 ? 75 ILE B N 1 ATOM 415 C CA . ILE A 1 102 ? -21.530 -8.100 21.299 1.00 55.64 ? 75 ILE B CA 1 ATOM 416 C C . ILE A 1 102 ? -21.285 -6.821 22.138 1.00 55.68 ? 75 ILE B C 1 ATOM 417 O O . ILE A 1 102 ? -20.181 -6.318 22.166 1.00 54.05 ? 75 ILE B O 1 ATOM 418 C CB . ILE A 1 102 ? -22.142 -7.724 19.927 1.00 53.67 ? 75 ILE B CB 1 ATOM 419 C CG1 . ILE A 1 102 ? -22.127 -8.933 18.985 1.00 57.16 ? 75 ILE B CG1 1 ATOM 420 C CG2 . ILE A 1 102 ? -21.342 -6.632 19.277 1.00 52.65 ? 75 ILE B CG2 1 ATOM 421 C CD1 . ILE A 1 102 ? -23.015 -8.771 17.764 1.00 56.32 ? 75 ILE B CD1 1 ATOM 422 N N . PHE A 1 103 ? -22.308 -6.306 22.813 1.00 52.87 ? 76 PHE B N 1 ATOM 423 C CA . PHE A 1 103 ? -22.141 -5.160 23.683 1.00 53.91 ? 76 PHE B CA 1 ATOM 424 C C . PHE A 1 103 ? -21.150 -5.380 24.787 1.00 54.97 ? 76 PHE B C 1 ATOM 425 O O . PHE A 1 103 ? -20.329 -4.541 25.062 1.00 60.61 ? 76 PHE B O 1 ATOM 426 C CB . PHE A 1 103 ? -23.437 -4.818 24.368 1.00 59.38 ? 76 PHE B CB 1 ATOM 427 C CG . PHE A 1 103 ? -23.321 -3.653 25.287 1.00 59.78 ? 76 PHE B CG 1 ATOM 428 C CD1 . PHE A 1 103 ? -23.287 -2.371 24.775 1.00 59.26 ? 76 PHE B CD1 1 ATOM 429 C CD2 . PHE A 1 103 ? -23.225 -3.835 26.658 1.00 64.41 ? 76 PHE B CD2 1 ATOM 430 C CE1 . PHE A 1 103 ? -23.188 -1.277 25.621 1.00 68.94 ? 76 PHE B CE1 1 ATOM 431 C CE2 . PHE A 1 103 ? -23.116 -2.745 27.518 1.00 64.34 ? 76 PHE B CE2 1 ATOM 432 C CZ . PHE A 1 103 ? -23.102 -1.462 27.000 1.00 68.29 ? 76 PHE B CZ 1 ATOM 433 N N . ALA A 1 104 ? -21.270 -6.512 25.454 1.00 64.27 ? 77 ALA B N 1 ATOM 434 C CA . ALA A 1 104 ? -20.347 -6.890 26.519 1.00 57.72 ? 77 ALA B CA 1 ATOM 435 C C . ALA A 1 104 ? -18.937 -7.055 25.965 1.00 51.41 ? 77 ALA B C 1 ATOM 436 O O . ALA A 1 104 ? -17.995 -6.608 26.570 1.00 55.07 ? 77 ALA B O 1 ATOM 437 C CB . ALA A 1 104 ? -20.817 -8.173 27.185 1.00 55.55 ? 77 ALA B CB 1 ATOM 438 N N . ILE A 1 105 ? -18.783 -7.681 24.815 1.00 50.07 ? 78 ILE B N 1 ATOM 439 C CA . ILE A 1 105 ? -17.441 -7.886 24.292 1.00 56.57 ? 78 ILE B CA 1 ATOM 440 C C . ILE A 1 105 ? -16.765 -6.559 23.908 1.00 65.45 ? 78 ILE B C 1 ATOM 441 O O . ILE A 1 105 ? -15.526 -6.436 23.953 1.00 61.16 ? 78 ILE B O 1 ATOM 442 C CB . ILE A 1 105 ? -17.433 -8.850 23.105 1.00 53.79 ? 78 ILE B CB 1 ATOM 443 C CG1 . ILE A 1 105 ? -17.618 -10.278 23.618 1.00 57.64 ? 78 ILE B CG1 1 ATOM 444 C CG2 . ILE A 1 105 ? -16.105 -8.781 22.376 1.00 55.99 ? 78 ILE B CG2 1 ATOM 445 C CD1 . ILE A 1 105 ? -17.939 -11.267 22.518 1.00 57.65 ? 78 ILE B CD1 1 ATOM 446 N N . GLU A 1 106 ? -17.580 -5.573 23.540 1.00 68.01 ? 79 GLU B N 1 ATOM 447 C CA . GLU A 1 106 ? -17.054 -4.315 23.075 1.00 67.11 ? 79 GLU B CA 1 ATOM 448 C C . GLU A 1 106 ? -16.786 -3.466 24.289 1.00 62.61 ? 79 GLU B C 1 ATOM 449 O O . GLU A 1 106 ? -15.720 -2.880 24.369 1.00 64.18 ? 79 GLU B O 1 ATOM 450 C CB . GLU A 1 106 ? -17.952 -3.673 21.993 1.00 74.03 ? 79 GLU B CB 1 ATOM 451 C CG . GLU A 1 106 ? -17.477 -4.095 20.583 1.00 86.62 ? 79 GLU B CG 1 ATOM 452 C CD . GLU A 1 106 ? -18.522 -3.999 19.452 1.00 95.66 ? 79 GLU B CD 1 ATOM 453 O OE1 . GLU A 1 106 ? -19.264 -2.987 19.386 1.00 93.14 ? 79 GLU B OE1 1 ATOM 454 O OE2 . GLU A 1 106 ? -18.568 -4.932 18.591 1.00 89.94 ? 79 GLU B OE2 1 ATOM 455 N N . GLU A 1 107 ? -17.710 -3.468 25.253 1.00 59.41 ? 80 GLU B N 1 ATOM 456 C CA . GLU A 1 107 ? -17.483 -2.909 26.626 1.00 61.16 ? 80 GLU B CA 1 ATOM 457 C C . GLU A 1 107 ? -16.186 -3.427 27.273 1.00 63.81 ? 80 GLU B C 1 ATOM 458 O O . GLU A 1 107 ? -15.429 -2.678 27.912 1.00 61.03 ? 80 GLU B O 1 ATOM 459 C CB . GLU A 1 107 ? -18.654 -3.241 27.579 1.00 58.10 ? 80 GLU B CB 1 ATOM 460 C CG . GLU A 1 107 ? -18.641 -2.502 28.911 1.00 57.52 ? 80 GLU B CG 1 ATOM 461 C CD . GLU A 1 107 ? -19.979 -2.576 29.671 1.00 65.81 ? 80 GLU B CD 1 ATOM 462 O OE1 . GLU A 1 107 ? -20.194 -3.556 30.410 1.00 69.86 ? 80 GLU B OE1 1 ATOM 463 O OE2 . GLU A 1 107 ? -20.824 -1.650 29.567 1.00 66.32 ? 80 GLU B OE2 1 ATOM 464 N N . ILE A 1 108 ? -15.913 -4.706 27.087 1.00 65.55 ? 81 ILE B N 1 ATOM 465 C CA . ILE A 1 108 ? -14.716 -5.265 27.652 1.00 67.59 ? 81 ILE B CA 1 ATOM 466 C C . ILE A 1 108 ? -13.461 -4.857 26.897 1.00 67.10 ? 81 ILE B C 1 ATOM 467 O O . ILE A 1 108 ? -12.428 -4.623 27.529 1.00 65.86 ? 81 ILE B O 1 ATOM 468 C CB . ILE A 1 108 ? -14.838 -6.778 27.784 1.00 66.13 ? 81 ILE B CB 1 ATOM 469 C CG1 . ILE A 1 108 ? -15.861 -7.060 28.892 1.00 70.17 ? 81 ILE B CG1 1 ATOM 470 C CG2 . ILE A 1 108 ? -13.475 -7.402 28.097 1.00 61.45 ? 81 ILE B CG2 1 ATOM 471 C CD1 . ILE A 1 108 ? -16.417 -8.462 28.858 1.00 77.03 ? 81 ILE B CD1 1 ATOM 472 N N . ASN A 1 109 ? -13.524 -4.761 25.571 1.00 63.30 ? 82 ASN B N 1 ATOM 473 C CA . ASN A 1 109 ? -12.324 -4.361 24.831 1.00 65.65 ? 82 ASN B CA 1 ATOM 474 C C . ASN A 1 109 ? -12.025 -2.866 25.052 1.00 69.57 ? 82 ASN B C 1 ATOM 475 O O . ASN A 1 109 ? -10.882 -2.443 24.994 1.00 69.79 ? 82 ASN B O 1 ATOM 476 C CB . ASN A 1 109 ? -12.405 -4.739 23.342 1.00 62.81 ? 82 ASN B CB 1 ATOM 477 C CG . ASN A 1 109 ? -12.269 -6.244 23.106 1.00 63.49 ? 82 ASN B CG 1 ATOM 478 O OD1 . ASN A 1 109 ? -11.576 -6.960 23.854 1.00 68.09 ? 82 ASN B OD1 1 ATOM 479 N ND2 . ASN A 1 109 ? -12.928 -6.734 22.070 1.00 53.32 ? 82 ASN B ND2 1 ATOM 480 N N . SER A 1 110 ? -13.054 -2.085 25.350 1.00 70.11 ? 83 SER B N 1 ATOM 481 C CA . SER A 1 110 ? -12.876 -0.698 25.744 1.00 75.87 ? 83 SER B CA 1 ATOM 482 C C . SER A 1 110 ? -12.250 -0.568 27.130 1.00 83.77 ? 83 SER B C 1 ATOM 483 O O . SER A 1 110 ? -11.418 0.297 27.348 1.00 90.33 ? 83 SER B O 1 ATOM 484 C CB . SER A 1 110 ? -14.220 0.026 25.739 1.00 77.61 ? 83 SER B CB 1 ATOM 485 O OG . SER A 1 110 ? -14.801 -0.054 24.450 1.00 83.15 ? 83 SER B OG 1 ATOM 486 N N . SER A 1 111 ? -12.649 -1.415 28.073 1.00 97.42 ? 84 SER B N 1 ATOM 487 C CA . SER A 1 111 ? -12.123 -1.292 29.433 1.00 95.96 ? 84 SER B CA 1 ATOM 488 C C . SER A 1 111 ? -10.620 -1.536 29.421 1.00 91.63 ? 84 SER B C 1 ATOM 489 O O . SER A 1 111 ? -10.146 -2.571 28.931 1.00 86.66 ? 84 SER B O 1 ATOM 490 C CB . SER A 1 111 ? -12.813 -2.232 30.430 1.00 99.08 ? 84 SER B CB 1 ATOM 491 O OG . SER A 1 111 ? -12.662 -1.754 31.765 1.00 99.54 ? 84 SER B OG 1 ATOM 492 N N . PRO A 1 112 ? -9.867 -0.559 29.938 1.00 95.95 ? 85 PRO B N 1 ATOM 493 C CA . PRO A 1 112 ? -8.416 -0.685 29.997 1.00 95.46 ? 85 PRO B CA 1 ATOM 494 C C . PRO A 1 112 ? -8.004 -1.651 31.115 1.00 87.34 ? 85 PRO B C 1 ATOM 495 O O . PRO A 1 112 ? -7.116 -2.479 30.906 1.00 86.30 ? 85 PRO B O 1 ATOM 496 C CB . PRO A 1 112 ? -7.955 0.751 30.264 1.00 103.31 ? 85 PRO B CB 1 ATOM 497 C CG . PRO A 1 112 ? -9.115 1.422 30.956 1.00 101.27 ? 85 PRO B CG 1 ATOM 498 C CD . PRO A 1 112 ? -10.360 0.675 30.592 1.00 96.20 ? 85 PRO B CD 1 ATOM 499 N N . ALA A 1 113 ? -8.674 -1.536 32.269 1.00 84.04 ? 86 ALA B N 1 ATOM 500 C CA . ALA A 1 113 ? -8.591 -2.474 33.405 1.00 85.55 ? 86 ALA B CA 1 ATOM 501 C C . ALA A 1 113 ? -8.632 -3.969 33.033 1.00 87.63 ? 86 ALA B C 1 ATOM 502 O O . ALA A 1 113 ? -7.658 -4.708 33.226 1.00 92.19 ? 86 ALA B O 1 ATOM 503 C CB . ALA A 1 113 ? -9.726 -2.165 34.382 1.00 87.00 ? 86 ALA B CB 1 ATOM 504 N N . LEU A 1 114 ? -9.765 -4.398 32.490 1.00 85.34 ? 87 LEU B N 1 ATOM 505 C CA . LEU A 1 114 ? -9.975 -5.789 32.140 1.00 80.12 ? 87 LEU B CA 1 ATOM 506 C C . LEU A 1 114 ? -9.233 -6.141 30.847 1.00 76.30 ? 87 LEU B C 1 ATOM 507 O O . LEU A 1 114 ? -9.454 -5.519 29.810 1.00 78.68 ? 87 LEU B O 1 ATOM 508 C CB . LEU A 1 114 ? -11.478 -6.041 32.005 1.00 79.84 ? 87 LEU B CB 1 ATOM 509 C CG . LEU A 1 114 ? -11.935 -7.463 32.337 1.00 82.32 ? 87 LEU B CG 1 ATOM 510 C CD1 . LEU A 1 114 ? -11.695 -7.807 33.793 1.00 83.78 ? 87 LEU B CD1 1 ATOM 511 C CD2 . LEU A 1 114 ? -13.413 -7.596 32.029 1.00 86.49 ? 87 LEU B CD2 1 ATOM 512 N N . LEU A 1 115 ? -8.331 -7.115 30.920 1.00 79.49 ? 88 LEU B N 1 ATOM 513 C CA . LEU A 1 115 ? -7.557 -7.581 29.748 1.00 80.57 ? 88 LEU B CA 1 ATOM 514 C C . LEU A 1 115 ? -6.985 -6.454 28.887 1.00 84.94 ? 88 LEU B C 1 ATOM 515 O O . LEU A 1 115 ? -7.522 -6.136 27.826 1.00 94.83 ? 88 LEU B O 1 ATOM 516 C CB . LEU A 1 115 ? -8.418 -8.501 28.889 1.00 79.54 ? 88 LEU B CB 1 ATOM 517 C CG . LEU A 1 115 ? -8.896 -9.766 29.599 1.00 76.97 ? 88 LEU B CG 1 ATOM 518 C CD1 . LEU A 1 115 ? -9.945 -10.492 28.790 1.00 72.78 ? 88 LEU B CD1 1 ATOM 519 C CD2 . LEU A 1 115 ? -7.714 -10.684 29.889 1.00 86.51 ? 88 LEU B CD2 1 ATOM 520 N N . PRO A 1 116 ? -5.897 -5.826 29.356 1.00 98.45 ? 89 PRO B N 1 ATOM 521 C CA . PRO A 1 116 ? -5.315 -4.691 28.629 1.00 94.34 ? 89 PRO B CA 1 ATOM 522 C C . PRO A 1 116 ? -4.512 -5.070 27.375 1.00 89.13 ? 89 PRO B C 1 ATOM 523 O O . PRO A 1 116 ? -4.762 -4.527 26.307 1.00 92.73 ? 89 PRO B O 1 ATOM 524 C CB . PRO A 1 116 ? -4.428 -4.012 29.680 1.00 97.06 ? 89 PRO B CB 1 ATOM 525 C CG . PRO A 1 116 ? -4.203 -5.027 30.748 1.00 95.92 ? 89 PRO B CG 1 ATOM 526 C CD . PRO A 1 116 ? -5.386 -5.934 30.737 1.00 98.82 ? 89 PRO B CD 1 ATOM 527 N N . ASN A 1 117 ? -3.565 -5.988 27.480 1.00 90.57 ? 90 ASN B N 1 ATOM 528 C CA . ASN A 1 117 ? -2.745 -6.319 26.312 1.00 95.57 ? 90 ASN B CA 1 ATOM 529 C C . ASN A 1 117 ? -3.556 -6.852 25.115 1.00 100.11 ? 90 ASN B C 1 ATOM 530 O O . ASN A 1 117 ? -3.200 -6.566 23.973 1.00 92.36 ? 90 ASN B O 1 ATOM 531 C CB . ASN A 1 117 ? -1.649 -7.318 26.696 1.00 99.15 ? 90 ASN B CB 1 ATOM 532 N N . LEU A 1 118 ? -4.653 -7.583 25.395 1.00 109.71 ? 91 LEU B N 1 ATOM 533 C CA . LEU A 1 118 ? -5.423 -8.403 24.404 1.00 98.64 ? 91 LEU B CA 1 ATOM 534 C C . LEU A 1 118 ? -6.795 -7.829 23.904 1.00 87.06 ? 91 LEU B C 1 ATOM 535 O O . LEU A 1 118 ? -7.360 -6.880 24.500 1.00 76.45 ? 91 LEU B O 1 ATOM 536 C CB . LEU A 1 118 ? -5.707 -9.788 25.018 1.00 105.06 ? 91 LEU B CB 1 ATOM 537 C CG . LEU A 1 118 ? -4.586 -10.797 25.307 1.00 113.85 ? 91 LEU B CG 1 ATOM 538 C CD1 . LEU A 1 118 ? -4.319 -11.700 24.109 1.00 111.73 ? 91 LEU B CD1 1 ATOM 539 C CD2 . LEU A 1 118 ? -3.295 -10.130 25.768 1.00 119.43 ? 91 LEU B CD2 1 ATOM 540 N N . THR A 1 119 ? -7.307 -8.423 22.809 1.00 72.35 ? 92 THR B N 1 ATOM 541 C CA . THR A 1 119 ? -8.715 -8.254 22.360 1.00 76.54 ? 92 THR B CA 1 ATOM 542 C C . THR A 1 119 ? -9.486 -9.586 22.304 1.00 74.97 ? 92 THR B C 1 ATOM 543 O O . THR A 1 119 ? -8.953 -10.626 21.887 1.00 78.29 ? 92 THR B O 1 ATOM 544 C CB . THR A 1 119 ? -8.844 -7.680 20.931 1.00 77.54 ? 92 THR B CB 1 ATOM 545 O OG1 . THR A 1 119 ? -8.203 -8.568 19.994 1.00 78.44 ? 92 THR B OG1 1 ATOM 546 C CG2 . THR A 1 119 ? -8.276 -6.291 20.845 1.00 73.62 ? 92 THR B CG2 1 ATOM 547 N N . LEU A 1 120 ? -10.754 -9.536 22.686 1.00 65.82 ? 93 LEU B N 1 ATOM 548 C CA . LEU A 1 120 ? -11.640 -10.680 22.525 1.00 64.78 ? 93 LEU B CA 1 ATOM 549 C C . LEU A 1 120 ? -12.385 -10.554 21.215 1.00 60.05 ? 93 LEU B C 1 ATOM 550 O O . LEU A 1 120 ? -13.001 -9.533 20.933 1.00 56.17 ? 93 LEU B O 1 ATOM 551 C CB . LEU A 1 120 ? -12.683 -10.703 23.635 1.00 68.33 ? 93 LEU B CB 1 ATOM 552 C CG . LEU A 1 120 ? -12.139 -10.823 25.041 1.00 71.78 ? 93 LEU B CG 1 ATOM 553 C CD1 . LEU A 1 120 ? -13.284 -10.753 26.035 1.00 72.06 ? 93 LEU B CD1 1 ATOM 554 C CD2 . LEU A 1 120 ? -11.349 -12.114 25.168 1.00 70.21 ? 93 LEU B CD2 1 ATOM 555 N N . GLY A 1 121 ? -12.368 -11.605 20.430 1.00 58.66 ? 94 GLY B N 1 ATOM 556 C CA . GLY A 1 121 ? -13.228 -11.672 19.266 1.00 62.74 ? 94 GLY B CA 1 ATOM 557 C C . GLY A 1 121 ? -14.442 -12.561 19.501 1.00 71.26 ? 94 GLY B C 1 ATOM 558 O O . GLY A 1 121 ? -14.720 -13.038 20.622 1.00 70.49 ? 94 GLY B O 1 ATOM 559 N N . TYR A 1 122 ? -15.174 -12.798 18.425 1.00 67.61 ? 95 TYR B N 1 ATOM 560 C CA . TYR A 1 122 ? -16.335 -13.617 18.527 1.00 59.83 ? 95 TYR B CA 1 ATOM 561 C C . TYR A 1 122 ? -16.745 -14.290 17.216 1.00 57.53 ? 95 TYR B C 1 ATOM 562 O O . TYR A 1 122 ? -16.510 -13.755 16.154 1.00 54.75 ? 95 TYR B O 1 ATOM 563 C CB . TYR A 1 122 ? -17.463 -12.783 19.111 1.00 59.18 ? 95 TYR B CB 1 ATOM 564 C CG . TYR A 1 122 ? -17.815 -11.493 18.412 1.00 60.22 ? 95 TYR B CG 1 ATOM 565 C CD1 . TYR A 1 122 ? -18.472 -11.490 17.180 1.00 62.50 ? 95 TYR B CD1 1 ATOM 566 C CD2 . TYR A 1 122 ? -17.567 -10.267 19.018 1.00 61.73 ? 95 TYR B CD2 1 ATOM 567 C CE1 . TYR A 1 122 ? -18.839 -10.298 16.559 1.00 59.36 ? 95 TYR B CE1 1 ATOM 568 C CE2 . TYR A 1 122 ? -17.935 -9.081 18.407 1.00 64.05 ? 95 TYR B CE2 1 ATOM 569 C CZ . TYR A 1 122 ? -18.573 -9.106 17.179 1.00 60.24 ? 95 TYR B CZ 1 ATOM 570 O OH . TYR A 1 122 ? -18.943 -7.932 16.597 1.00 62.67 ? 95 TYR B OH 1 ATOM 571 N N . ARG A 1 123 ? -17.309 -15.493 17.316 1.00 55.99 ? 96 ARG B N 1 ATOM 572 C CA . ARG A 1 123 ? -17.937 -16.160 16.190 1.00 61.39 ? 96 ARG B CA 1 ATOM 573 C C . ARG A 1 123 ? -19.306 -16.627 16.636 1.00 58.92 ? 96 ARG B C 1 ATOM 574 O O . ARG A 1 123 ? -19.410 -17.608 17.362 1.00 58.87 ? 96 ARG B O 1 ATOM 575 C CB . ARG A 1 123 ? -17.106 -17.338 15.699 1.00 68.76 ? 96 ARG B CB 1 ATOM 576 C CG . ARG A 1 123 ? -15.933 -16.932 14.810 1.00 85.93 ? 96 ARG B CG 1 ATOM 577 C CD . ARG A 1 123 ? -14.819 -17.982 14.787 1.00 92.70 ? 96 ARG B CD 1 ATOM 578 N NE . ARG A 1 123 ? -15.291 -19.291 14.305 1.00 105.34 ? 96 ARG B NE 1 ATOM 579 C CZ . ARG A 1 123 ? -14.753 -20.481 14.617 1.00 112.83 ? 96 ARG B CZ 1 ATOM 580 N NH1 . ARG A 1 123 ? -13.700 -20.582 15.439 1.00 110.84 ? 96 ARG B NH1 1 ATOM 581 N NH2 . ARG A 1 123 ? -15.281 -21.595 14.105 1.00 105.80 ? 96 ARG B NH2 1 ATOM 582 N N . ILE A 1 124 ? -20.351 -15.937 16.167 1.00 53.44 ? 97 ILE B N 1 ATOM 583 C CA . ILE A 1 124 ? -21.702 -16.162 16.634 1.00 49.30 ? 97 ILE B CA 1 ATOM 584 C C . ILE A 1 124 ? -22.631 -16.621 15.532 1.00 52.47 ? 97 ILE B C 1 ATOM 585 O O . ILE A 1 124 ? -22.701 -15.988 14.478 1.00 54.32 ? 97 ILE B O 1 ATOM 586 C CB . ILE A 1 124 ? -22.253 -14.881 17.259 1.00 48.09 ? 97 ILE B CB 1 ATOM 587 C CG1 . ILE A 1 124 ? -21.274 -14.402 18.354 1.00 45.45 ? 97 ILE B CG1 1 ATOM 588 C CG2 . ILE A 1 124 ? -23.642 -15.151 17.802 1.00 48.18 ? 97 ILE B CG2 1 ATOM 589 C CD1 . ILE A 1 124 ? -21.631 -13.122 19.043 1.00 44.21 ? 97 ILE B CD1 1 ATOM 590 N N . PHE A 1 125 ? -23.367 -17.700 15.802 1.00 52.10 ? 98 PHE B N 1 ATOM 591 C CA . PHE A 1 125 ? -24.290 -18.315 14.840 1.00 50.05 ? 98 PHE B CA 1 ATOM 592 C C . PHE A 1 125 ? -25.724 -18.420 15.340 1.00 51.11 ? 98 PHE B C 1 ATOM 593 O O . PHE A 1 125 ? -25.983 -18.427 16.535 1.00 56.77 ? 98 PHE B O 1 ATOM 594 C CB . PHE A 1 125 ? -23.834 -19.726 14.509 1.00 51.04 ? 98 PHE B CB 1 ATOM 595 C CG . PHE A 1 125 ? -22.455 -19.798 13.971 1.00 58.53 ? 98 PHE B CG 1 ATOM 596 C CD1 . PHE A 1 125 ? -22.210 -19.542 12.634 1.00 67.01 ? 98 PHE B CD1 1 ATOM 597 C CD2 . PHE A 1 125 ? -21.397 -20.137 14.789 1.00 66.47 ? 98 PHE B CD2 1 ATOM 598 C CE1 . PHE A 1 125 ? -20.926 -19.602 12.124 1.00 69.78 ? 98 PHE B CE1 1 ATOM 599 C CE2 . PHE A 1 125 ? -20.113 -20.230 14.280 1.00 69.61 ? 98 PHE B CE2 1 ATOM 600 C CZ . PHE A 1 125 ? -19.877 -19.959 12.945 1.00 66.00 ? 98 PHE B CZ 1 ATOM 601 N N . ASP A 1 126 ? -26.646 -18.547 14.387 1.00 58.57 ? 99 ASP B N 1 ATOM 602 C CA . ASP A 1 126 ? -28.094 -18.755 14.620 1.00 55.46 ? 99 ASP B CA 1 ATOM 603 C C . ASP A 1 126 ? -28.380 -20.273 14.715 1.00 50.30 ? 99 ASP B C 1 ATOM 604 O O . ASP A 1 126 ? -27.939 -21.027 13.866 1.00 49.64 ? 99 ASP B O 1 ATOM 605 C CB . ASP A 1 126 ? -28.871 -18.129 13.440 1.00 58.20 ? 99 ASP B CB 1 ATOM 606 C CG . ASP A 1 126 ? -30.398 -18.238 13.569 1.00 60.26 ? 99 ASP B CG 1 ATOM 607 O OD1 . ASP A 1 126 ? -30.916 -18.575 14.650 1.00 63.96 ? 99 ASP B OD1 1 ATOM 608 O OD2 . ASP A 1 126 ? -31.093 -17.961 12.563 1.00 59.64 ? 99 ASP B OD2 1 ATOM 609 N N . THR A 1 127 ? -29.107 -20.693 15.739 1.00 44.90 ? 100 THR B N 1 ATOM 610 C CA . THR A 1 127 ? -29.452 -22.079 15.961 1.00 47.11 ? 100 THR B CA 1 ATOM 611 C C . THR A 1 127 ? -30.813 -22.432 15.386 1.00 49.80 ? 100 THR B C 1 ATOM 612 O O . THR A 1 127 ? -31.182 -23.632 15.296 1.00 49.55 ? 100 THR B O 1 ATOM 613 C CB . THR A 1 127 ? -29.670 -22.328 17.450 1.00 47.48 ? 100 THR B CB 1 ATOM 614 O OG1 . THR A 1 127 ? -30.723 -21.450 17.921 1.00 43.85 ? 100 THR B OG1 1 ATOM 615 C CG2 . THR A 1 127 ? -28.416 -22.103 18.213 1.00 48.43 ? 100 THR B CG2 1 ATOM 616 N N . CYS A 1 128 ? -31.602 -21.399 15.112 1.00 45.48 ? 101 CYS B N 1 ATOM 617 C CA . CYS A 1 128 ? -33.024 -21.579 14.785 1.00 53.17 ? 101 CYS B CA 1 ATOM 618 C C . CYS A 1 128 ? -33.800 -22.501 15.756 1.00 52.16 ? 101 CYS B C 1 ATOM 619 O O . CYS A 1 128 ? -34.689 -23.234 15.340 1.00 54.24 ? 101 CYS B O 1 ATOM 620 C CB . CYS A 1 128 ? -33.152 -22.080 13.342 1.00 61.48 ? 101 CYS B CB 1 ATOM 621 S SG . CYS A 1 128 ? -32.063 -21.128 12.261 1.00 69.09 ? 101 CYS B SG 1 ATOM 622 N N . ASN A 1 129 ? -33.505 -22.425 17.051 1.00 46.92 ? 102 ASN B N 1 ATOM 623 C CA . ASN A 1 129 ? -34.017 -23.413 17.996 1.00 48.79 ? 102 ASN B CA 1 ATOM 624 C C . ASN A 1 129 ? -33.921 -24.814 17.476 1.00 46.35 ? 102 ASN B C 1 ATOM 625 O O . ASN A 1 129 ? -34.856 -25.557 17.640 1.00 50.51 ? 102 ASN B O 1 ATOM 626 C CB . ASN A 1 129 ? -35.478 -23.185 18.346 1.00 47.69 ? 102 ASN B CB 1 ATOM 627 C CG . ASN A 1 129 ? -35.681 -21.978 19.164 1.00 55.35 ? 102 ASN B CG 1 ATOM 628 O OD1 . ASN A 1 129 ? -35.030 -21.792 20.208 1.00 57.81 ? 102 ASN B OD1 1 ATOM 629 N ND2 . ASN A 1 129 ? -36.572 -21.105 18.697 1.00 62.55 ? 102 ASN B ND2 1 ATOM 630 N N . THR A 1 130 ? -32.824 -25.172 16.825 1.00 49.69 ? 103 THR B N 1 ATOM 631 C CA . THR A 1 130 ? -32.767 -26.455 16.151 1.00 52.48 ? 103 THR B CA 1 ATOM 632 C C . THR A 1 130 ? -31.458 -27.094 16.489 1.00 50.26 ? 103 THR B C 1 ATOM 633 O O . THR A 1 130 ? -30.419 -26.468 16.319 1.00 52.10 ? 103 THR B O 1 ATOM 634 C CB . THR A 1 130 ? -32.972 -26.324 14.614 1.00 57.21 ? 103 THR B CB 1 ATOM 635 O OG1 . THR A 1 130 ? -34.293 -25.827 14.340 1.00 57.61 ? 103 THR B OG1 1 ATOM 636 C CG2 . THR A 1 130 ? -32.861 -27.681 13.928 1.00 58.59 ? 103 THR B CG2 1 ATOM 637 N N . VAL A 1 131 ? -31.515 -28.332 16.993 1.00 44.49 ? 104 VAL B N 1 ATOM 638 C CA . VAL A 1 131 ? -30.305 -29.101 17.203 1.00 42.07 ? 104 VAL B CA 1 ATOM 639 C C . VAL A 1 131 ? -29.426 -29.109 15.954 1.00 45.55 ? 104 VAL B C 1 ATOM 640 O O . VAL A 1 131 ? -28.209 -28.910 16.038 1.00 47.65 ? 104 VAL B O 1 ATOM 641 C CB . VAL A 1 131 ? -30.597 -30.551 17.592 1.00 38.74 ? 104 VAL B CB 1 ATOM 642 C CG1 . VAL A 1 131 ? -29.332 -31.388 17.573 1.00 42.76 ? 104 VAL B CG1 1 ATOM 643 C CG2 . VAL A 1 131 ? -31.184 -30.619 18.965 1.00 37.62 ? 104 VAL B CG2 1 ATOM 644 N N . SER A 1 132 ? -30.019 -29.364 14.796 1.00 47.79 ? 105 SER B N 1 ATOM 645 C CA . SER A 1 132 ? -29.182 -29.555 13.610 1.00 48.46 ? 105 SER B CA 1 ATOM 646 C C . SER A 1 132 ? -28.358 -28.301 13.271 1.00 51.72 ? 105 SER B C 1 ATOM 647 O O . SER A 1 132 ? -27.127 -28.362 13.121 1.00 53.68 ? 105 SER B O 1 ATOM 648 C CB . SER A 1 132 ? -29.992 -30.070 12.441 1.00 42.21 ? 105 SER B CB 1 ATOM 649 O OG . SER A 1 132 ? -30.910 -29.100 11.982 1.00 48.88 ? 105 SER B OG 1 ATOM 650 N N . LYS A 1 133 ? -28.999 -27.152 13.208 1.00 54.63 ? 106 LYS B N 1 ATOM 651 C CA . LYS A 1 133 ? -28.242 -25.918 12.921 1.00 57.80 ? 106 LYS B CA 1 ATOM 652 C C . LYS A 1 133 ? -27.188 -25.662 13.997 1.00 50.30 ? 106 LYS B C 1 ATOM 653 O O . LYS A 1 133 ? -26.089 -25.242 13.706 1.00 53.89 ? 106 LYS B O 1 ATOM 654 C CB . LYS A 1 133 ? -29.177 -24.724 12.854 1.00 61.15 ? 106 LYS B CB 1 ATOM 655 C CG . LYS A 1 133 ? -30.300 -24.885 11.850 1.00 67.36 ? 106 LYS B CG 1 ATOM 656 C CD . LYS A 1 133 ? -29.814 -24.622 10.435 1.00 71.90 ? 106 LYS B CD 1 ATOM 657 C CE . LYS A 1 133 ? -30.958 -24.809 9.448 1.00 76.80 ? 106 LYS B CE 1 ATOM 658 N NZ . LYS A 1 133 ? -30.532 -24.645 8.037 1.00 79.91 ? 106 LYS B NZ 1 ATOM 659 N N . ALA A 1 134 ? -27.539 -25.926 15.245 1.00 46.14 ? 107 ALA B N 1 ATOM 660 C CA . ALA A 1 134 ? -26.647 -25.676 16.348 1.00 45.04 ? 107 ALA B CA 1 ATOM 661 C C . ALA A 1 134 ? -25.452 -26.593 16.256 1.00 47.27 ? 107 ALA B C 1 ATOM 662 O O . ALA A 1 134 ? -24.338 -26.164 16.519 1.00 51.78 ? 107 ALA B O 1 ATOM 663 C CB . ALA A 1 134 ? -27.363 -25.877 17.663 1.00 46.28 ? 107 ALA B CB 1 ATOM 664 N N . LEU A 1 135 ? -25.672 -27.848 15.880 1.00 46.68 ? 108 LEU B N 1 ATOM 665 C CA . LEU A 1 135 ? -24.557 -28.767 15.670 1.00 51.42 ? 108 LEU B CA 1 ATOM 666 C C . LEU A 1 135 ? -23.632 -28.414 14.488 1.00 50.02 ? 108 LEU B C 1 ATOM 667 O O . LEU A 1 135 ? -22.434 -28.651 14.567 1.00 46.26 ? 108 LEU B O 1 ATOM 668 C CB . LEU A 1 135 ? -25.054 -30.198 15.500 1.00 52.63 ? 108 LEU B CB 1 ATOM 669 C CG . LEU A 1 135 ? -25.450 -30.956 16.749 1.00 52.83 ? 108 LEU B CG 1 ATOM 670 C CD1 . LEU A 1 135 ? -25.491 -32.422 16.407 1.00 51.75 ? 108 LEU B CD1 1 ATOM 671 C CD2 . LEU A 1 135 ? -24.470 -30.769 17.891 1.00 61.62 ? 108 LEU B CD2 1 ATOM 672 N N . GLU A 1 136 ? -24.173 -27.888 13.387 1.00 57.92 ? 109 GLU B N 1 ATOM 673 C CA . GLU A 1 136 ? -23.303 -27.454 12.275 1.00 60.84 ? 109 GLU B CA 1 ATOM 674 C C . GLU A 1 136 ? -22.348 -26.441 12.877 1.00 59.82 ? 109 GLU B C 1 ATOM 675 O O . GLU A 1 136 ? -21.150 -26.591 12.759 1.00 56.26 ? 109 GLU B O 1 ATOM 676 C CB . GLU A 1 136 ? -24.059 -26.769 11.128 1.00 65.84 ? 109 GLU B CB 1 ATOM 677 C CG . GLU A 1 136 ? -24.637 -27.652 10.036 1.00 77.40 ? 109 GLU B CG 1 ATOM 678 C CD . GLU A 1 136 ? -25.526 -26.864 9.055 1.00 93.38 ? 109 GLU B CD 1 ATOM 679 O OE1 . GLU A 1 136 ? -25.597 -25.609 9.142 1.00 101.59 ? 109 GLU B OE1 1 ATOM 680 O OE2 . GLU A 1 136 ? -26.174 -27.495 8.188 1.00 100.90 ? 109 GLU B OE2 1 ATOM 681 N N . ALA A 1 137 ? -22.902 -25.429 13.550 1.00 54.71 ? 110 ALA B N 1 ATOM 682 C CA . ALA A 1 137 ? -22.115 -24.327 14.049 1.00 50.30 ? 110 ALA B CA 1 ATOM 683 C C . ALA A 1 137 ? -21.076 -24.843 15.041 1.00 49.83 ? 110 ALA B C 1 ATOM 684 O O . ALA A 1 137 ? -19.952 -24.405 15.106 1.00 51.04 ? 110 ALA B O 1 ATOM 685 C CB . ALA A 1 137 ? -23.021 -23.312 14.693 1.00 49.57 ? 110 ALA B CB 1 ATOM 686 N N . THR A 1 138 ? -21.443 -25.835 15.793 1.00 51.27 ? 111 THR B N 1 ATOM 687 C CA . THR A 1 138 ? -20.559 -26.297 16.811 1.00 55.24 ? 111 THR B CA 1 ATOM 688 C C . THR A 1 138 ? -19.401 -27.061 16.186 1.00 54.03 ? 111 THR B C 1 ATOM 689 O O . THR A 1 138 ? -18.264 -27.008 16.681 1.00 56.90 ? 111 THR B O 1 ATOM 690 C CB . THR A 1 138 ? -21.337 -27.156 17.823 1.00 54.12 ? 111 THR B CB 1 ATOM 691 O OG1 . THR A 1 138 ? -22.234 -26.307 18.542 1.00 49.13 ? 111 THR B OG1 1 ATOM 692 C CG2 . THR A 1 138 ? -20.405 -27.816 18.793 1.00 57.38 ? 111 THR B CG2 1 ATOM 693 N N . LEU A 1 139 ? -19.680 -27.793 15.122 1.00 52.22 ? 112 LEU B N 1 ATOM 694 C CA . LEU A 1 139 ? -18.604 -28.501 14.420 1.00 57.52 ? 112 LEU B CA 1 ATOM 695 C C . LEU A 1 139 ? -17.507 -27.527 13.941 1.00 55.79 ? 112 LEU B C 1 ATOM 696 O O . LEU A 1 139 ? -16.338 -27.868 13.922 1.00 52.70 ? 112 LEU B O 1 ATOM 697 C CB . LEU A 1 139 ? -19.166 -29.298 13.246 1.00 58.10 ? 112 LEU B CB 1 ATOM 698 C CG . LEU A 1 139 ? -19.888 -30.577 13.650 1.00 57.48 ? 112 LEU B CG 1 ATOM 699 C CD1 . LEU A 1 139 ? -20.615 -31.100 12.447 1.00 59.13 ? 112 LEU B CD1 1 ATOM 700 C CD2 . LEU A 1 139 ? -18.930 -31.642 14.138 1.00 57.61 ? 112 LEU B CD2 1 ATOM 701 N N . SER A 1 140 ? -17.903 -26.307 13.599 1.00 55.16 ? 113 SER B N 1 ATOM 702 C CA . SER A 1 140 ? -16.964 -25.288 13.222 1.00 57.70 ? 113 SER B CA 1 ATOM 703 C C . SER A 1 140 ? -16.215 -24.755 14.436 1.00 54.96 ? 113 SER B C 1 ATOM 704 O O . SER A 1 140 ? -15.050 -24.453 14.338 1.00 67.74 ? 113 SER B O 1 ATOM 705 C CB . SER A 1 140 ? -17.670 -24.151 12.457 1.00 58.88 ? 113 SER B CB 1 ATOM 706 O OG . SER A 1 140 ? -18.000 -23.077 13.316 1.00 58.54 ? 113 SER B OG 1 ATOM 707 N N . PHE A 1 141 ? -16.875 -24.603 15.575 1.00 55.85 ? 114 PHE B N 1 ATOM 708 C CA . PHE A 1 141 ? -16.196 -24.135 16.795 1.00 52.38 ? 114 PHE B CA 1 ATOM 709 C C . PHE A 1 141 ? -15.054 -25.048 17.206 1.00 56.11 ? 114 PHE B C 1 ATOM 710 O O . PHE A 1 141 ? -14.053 -24.573 17.714 1.00 71.50 ? 114 PHE B O 1 ATOM 711 C CB . PHE A 1 141 ? -17.148 -24.133 17.999 1.00 53.81 ? 114 PHE B CB 1 ATOM 712 C CG . PHE A 1 141 ? -18.142 -23.031 18.022 1.00 46.94 ? 114 PHE B CG 1 ATOM 713 C CD1 . PHE A 1 141 ? -17.890 -21.805 17.438 1.00 48.17 ? 114 PHE B CD1 1 ATOM 714 C CD2 . PHE A 1 141 ? -19.336 -23.231 18.683 1.00 48.81 ? 114 PHE B CD2 1 ATOM 715 C CE1 . PHE A 1 141 ? -18.827 -20.786 17.498 1.00 53.66 ? 114 PHE B CE1 1 ATOM 716 C CE2 . PHE A 1 141 ? -20.296 -22.234 18.746 1.00 52.63 ? 114 PHE B CE2 1 ATOM 717 C CZ . PHE A 1 141 ? -20.035 -21.000 18.152 1.00 57.05 ? 114 PHE B CZ 1 ATOM 718 N N . VAL A 1 142 ? -15.241 -26.356 17.035 1.00 59.04 ? 115 VAL B N 1 ATOM 719 C CA . VAL A 1 142 ? -14.254 -27.362 17.406 1.00 60.37 ? 115 VAL B CA 1 ATOM 720 C C . VAL A 1 142 ? -13.447 -27.881 16.214 1.00 61.78 ? 115 VAL B C 1 ATOM 721 O O . VAL A 1 142 ? -12.930 -28.993 16.271 1.00 64.77 ? 115 VAL B O 1 ATOM 722 C CB . VAL A 1 142 ? -14.902 -28.598 18.102 1.00 61.54 ? 115 VAL B CB 1 ATOM 723 C CG1 . VAL A 1 142 ? -15.699 -28.174 19.319 1.00 69.96 ? 115 VAL B CG1 1 ATOM 724 C CG2 . VAL A 1 142 ? -15.783 -29.390 17.163 1.00 58.40 ? 115 VAL B CG2 1 ATOM 725 N N . ALA A 1 143 ? -13.311 -27.098 15.148 1.00 63.55 ? 116 ALA B N 1 ATOM 726 C CA . ALA A 1 143 ? -12.726 -27.627 13.904 1.00 66.12 ? 116 ALA B CA 1 ATOM 727 C C . ALA A 1 143 ? -11.252 -27.942 14.086 1.00 66.56 ? 116 ALA B C 1 ATOM 728 O O . ALA A 1 143 ? -10.758 -28.947 13.580 1.00 57.21 ? 116 ALA B O 1 ATOM 729 C CB . ALA A 1 143 ? -12.937 -26.656 12.752 1.00 65.71 ? 116 ALA B CB 1 ATOM 730 N N . GLN A 1 144 ? -10.579 -27.089 14.857 1.00 79.07 ? 117 GLN B N 1 ATOM 731 C CA . GLN A 1 144 ? -9.154 -27.232 15.126 1.00 89.45 ? 117 GLN B CA 1 ATOM 732 C C . GLN A 1 144 ? -8.923 -28.476 16.007 1.00 89.97 ? 117 GLN B C 1 ATOM 733 O O . GLN A 1 144 ? -8.461 -29.508 15.503 1.00 84.50 ? 117 GLN B O 1 ATOM 734 C CB . GLN A 1 144 ? -8.594 -25.931 15.736 1.00 94.88 ? 117 GLN B CB 1 ATOM 735 C CG . GLN A 1 144 ? -7.208 -25.547 15.227 1.00 104.34 ? 117 GLN B CG 1 ATOM 736 C CD . GLN A 1 144 ? -6.112 -26.406 15.833 1.00 105.91 ? 117 GLN B CD 1 ATOM 737 O OE1 . GLN A 1 144 ? -5.620 -26.132 16.936 1.00 104.44 ? 117 GLN B OE1 1 ATOM 738 N NE2 . GLN A 1 144 ? -5.727 -27.458 15.118 1.00 104.20 ? 117 GLN B NE2 1 ATOM 739 N N . ASN A 1 145 ? -9.241 -28.360 17.300 1.00 92.10 ? 118 ASN B N 1 ATOM 740 C CA . ASN A 1 145 ? -9.463 -29.499 18.248 1.00 93.23 ? 118 ASN B CA 1 ATOM 741 C C . ASN A 1 145 ? -9.811 -30.885 17.673 1.00 93.34 ? 118 ASN B C 1 ATOM 742 O O . ASN A 1 145 ? -9.318 -31.910 18.163 1.00 88.64 ? 118 ASN B O 1 ATOM 743 C CB . ASN A 1 145 ? -10.609 -29.174 19.230 1.00 90.94 ? 118 ASN B CB 1 ATOM 744 C CG . ASN A 1 145 ? -10.601 -27.736 19.718 1.00 85.15 ? 118 ASN B CG 1 ATOM 745 O OD1 . ASN A 1 145 ? -10.079 -27.438 20.786 1.00 88.27 ? 118 ASN B OD1 1 ATOM 746 N ND2 . ASN A 1 145 ? -11.200 -26.842 18.943 1.00 85.70 ? 118 ASN B ND2 1 ATOM 747 N N . LYS A 1 146 ? -10.713 -30.913 16.689 1.00 104.24 ? 119 LYS B N 1 ATOM 748 C CA . LYS A 1 146 ? -11.148 -32.165 16.051 1.00 108.30 ? 119 LYS B CA 1 ATOM 749 C C . LYS A 1 146 ? -10.059 -32.782 15.165 1.00 119.46 ? 119 LYS B C 1 ATOM 750 O O . LYS A 1 146 ? -9.826 -34.004 15.216 1.00 116.27 ? 119 LYS B O 1 ATOM 751 C CB . LYS A 1 146 ? -12.394 -31.935 15.207 1.00 100.16 ? 119 LYS B CB 1 ATOM 752 C CG . LYS A 1 146 ? -12.950 -33.223 14.638 1.00 101.34 ? 119 LYS B CG 1 ATOM 753 C CD . LYS A 1 146 ? -13.623 -32.978 13.312 1.00 107.53 ? 119 LYS B CD 1 ATOM 754 C CE . LYS A 1 146 ? -13.382 -34.090 12.297 1.00 116.03 ? 119 LYS B CE 1 ATOM 755 N NZ . LYS A 1 146 ? -14.412 -35.172 12.308 1.00 117.17 ? 119 LYS B NZ 1 ATOM 756 N N . ILE A 1 147 ? -9.421 -31.938 14.343 1.00 117.19 ? 120 ILE B N 1 ATOM 757 C CA . ILE A 1 147 ? -8.255 -32.338 13.547 1.00 104.90 ? 120 ILE B CA 1 ATOM 758 C C . ILE A 1 147 ? -7.148 -32.912 14.458 1.00 104.45 ? 120 ILE B C 1 ATOM 759 O O . ILE A 1 147 ? -6.441 -33.832 14.065 1.00 113.20 ? 120 ILE B O 1 ATOM 760 C CB . ILE A 1 147 ? -7.726 -31.170 12.684 1.00 96.34 ? 120 ILE B CB 1 ATOM 761 N N . ASP A 1 148 ? -7.031 -32.388 15.680 1.00 111.01 ? 121 ASP B N 1 ATOM 762 C CA . ASP A 1 148 ? -6.182 -32.969 16.741 1.00 108.59 ? 121 ASP B CA 1 ATOM 763 C C . ASP A 1 148 ? -6.969 -33.890 17.696 1.00 109.14 ? 121 ASP B C 1 ATOM 764 O O . ASP A 1 148 ? -7.612 -34.863 17.288 1.00 103.51 ? 121 ASP B O 1 ATOM 765 C CB . ASP A 1 148 ? -5.533 -31.853 17.574 1.00 108.85 ? 121 ASP B CB 1 ATOM 766 C CG . ASP A 1 148 ? -4.690 -30.885 16.734 1.00 115.13 ? 121 ASP B CG 1 ATOM 767 O OD1 . ASP A 1 148 ? -4.346 -31.199 15.572 1.00 116.25 ? 121 ASP B OD1 1 ATOM 768 O OD2 . ASP A 1 148 ? -4.360 -29.798 17.248 1.00 110.22 ? 121 ASP B OD2 1 ATOM 769 N N . SER A 1 164 ? -9.473 -20.326 16.317 1.00 68.36 ? 137 SER B N 1 ATOM 770 C CA . SER A 1 164 ? -9.687 -21.188 17.478 1.00 72.54 ? 137 SER B CA 1 ATOM 771 C C . SER A 1 164 ? -10.592 -20.621 18.630 1.00 71.87 ? 137 SER B C 1 ATOM 772 O O . SER A 1 164 ? -10.418 -19.478 19.088 1.00 78.01 ? 137 SER B O 1 ATOM 773 C CB . SER A 1 164 ? -8.338 -21.570 18.045 1.00 69.08 ? 137 SER B CB 1 ATOM 774 O OG . SER A 1 164 ? -8.518 -22.591 18.993 1.00 62.38 ? 137 SER B OG 1 ATOM 775 N N . THR A 1 165 ? -11.526 -21.450 19.113 1.00 69.35 ? 138 THR B N 1 ATOM 776 C CA . THR A 1 165 ? -12.612 -21.012 20.021 1.00 65.85 ? 138 THR B CA 1 ATOM 777 C C . THR A 1 165 ? -12.392 -21.431 21.469 1.00 61.08 ? 138 THR B C 1 ATOM 778 O O . THR A 1 165 ? -12.271 -22.606 21.781 1.00 63.33 ? 138 THR B O 1 ATOM 779 C CB . THR A 1 165 ? -13.986 -21.561 19.591 1.00 67.79 ? 138 THR B CB 1 ATOM 780 O OG1 . THR A 1 165 ? -14.292 -21.142 18.255 1.00 79.76 ? 138 THR B OG1 1 ATOM 781 C CG2 . THR A 1 165 ? -15.053 -21.017 20.483 1.00 70.88 ? 138 THR B CG2 1 ATOM 782 N N . ILE A 1 166 ? -12.381 -20.461 22.364 1.00 56.80 ? 139 ILE B N 1 ATOM 783 C CA . ILE A 1 166 ? -11.960 -20.714 23.730 1.00 58.07 ? 139 ILE B CA 1 ATOM 784 C C . ILE A 1 166 ? -13.113 -21.065 24.688 1.00 57.82 ? 139 ILE B C 1 ATOM 785 O O . ILE A 1 166 ? -12.908 -21.687 25.719 1.00 55.24 ? 139 ILE B O 1 ATOM 786 C CB . ILE A 1 166 ? -11.138 -19.503 24.247 1.00 58.11 ? 139 ILE B CB 1 ATOM 787 C CG1 . ILE A 1 166 ? -9.988 -20.025 25.051 1.00 60.75 ? 139 ILE B CG1 1 ATOM 788 C CG2 . ILE A 1 166 ? -11.966 -18.473 25.009 1.00 55.80 ? 139 ILE B CG2 1 ATOM 789 C CD1 . ILE A 1 166 ? -9.021 -20.781 24.155 1.00 62.40 ? 139 ILE B CD1 1 ATOM 790 N N . ALA A 1 167 ? -14.315 -20.648 24.322 1.00 54.49 ? 140 ALA B N 1 ATOM 791 C CA . ALA A 1 167 ? -15.480 -20.754 25.158 1.00 52.38 ? 140 ALA B CA 1 ATOM 792 C C . ALA A 1 167 ? -16.711 -20.431 24.285 1.00 52.26 ? 140 ALA B C 1 ATOM 793 O O . ALA A 1 167 ? -16.613 -19.691 23.303 1.00 50.09 ? 140 ALA B O 1 ATOM 794 C CB . ALA A 1 167 ? -15.354 -19.781 26.313 1.00 52.67 ? 140 ALA B CB 1 ATOM 795 N N . VAL A 1 168 ? -17.858 -21.002 24.625 1.00 49.43 ? 141 VAL B N 1 ATOM 796 C CA . VAL A 1 168 ? -19.086 -20.796 23.853 1.00 46.08 ? 141 VAL B CA 1 ATOM 797 C C . VAL A 1 168 ? -20.145 -20.317 24.805 1.00 41.84 ? 141 VAL B C 1 ATOM 798 O O . VAL A 1 168 ? -20.272 -20.862 25.888 1.00 48.98 ? 141 VAL B O 1 ATOM 799 C CB . VAL A 1 168 ? -19.573 -22.103 23.190 1.00 46.34 ? 141 VAL B CB 1 ATOM 800 C CG1 . VAL A 1 168 ? -20.940 -21.936 22.574 1.00 50.54 ? 141 VAL B CG1 1 ATOM 801 C CG2 . VAL A 1 168 ? -18.614 -22.521 22.123 1.00 46.74 ? 141 VAL B CG2 1 ATOM 802 N N . VAL A 1 169 ? -20.891 -19.302 24.380 1.00 43.93 ? 142 VAL B N 1 ATOM 803 C CA . VAL A 1 169 ? -22.007 -18.702 25.114 1.00 45.06 ? 142 VAL B CA 1 ATOM 804 C C . VAL A 1 169 ? -23.270 -19.197 24.446 1.00 46.49 ? 142 VAL B C 1 ATOM 805 O O . VAL A 1 169 ? -23.473 -18.897 23.304 1.00 51.87 ? 142 VAL B O 1 ATOM 806 C CB . VAL A 1 169 ? -21.953 -17.192 24.954 1.00 44.72 ? 142 VAL B CB 1 ATOM 807 C CG1 . VAL A 1 169 ? -23.211 -16.532 25.472 1.00 45.43 ? 142 VAL B CG1 1 ATOM 808 C CG2 . VAL A 1 169 ? -20.705 -16.649 25.626 1.00 46.47 ? 142 VAL B CG2 1 ATOM 809 N N . GLY A 1 170 ? -24.091 -19.974 25.140 1.00 47.41 ? 143 GLY B N 1 ATOM 810 C CA . GLY A 1 170 ? -25.247 -20.662 24.537 1.00 44.95 ? 143 GLY B CA 1 ATOM 811 C C . GLY A 1 170 ? -25.446 -22.081 25.055 1.00 42.91 ? 143 GLY B C 1 ATOM 812 O O . GLY A 1 170 ? -24.717 -22.514 25.942 1.00 42.85 ? 143 GLY B O 1 ATOM 813 N N . ALA A 1 171 ? -26.438 -22.809 24.539 1.00 42.05 ? 144 ALA B N 1 ATOM 814 C CA . ALA A 1 171 ? -27.492 -22.265 23.654 1.00 43.29 ? 144 ALA B CA 1 ATOM 815 C C . ALA A 1 171 ? -28.723 -21.825 24.500 1.00 45.15 ? 144 ALA B C 1 ATOM 816 O O . ALA A 1 171 ? -28.609 -21.629 25.719 1.00 48.85 ? 144 ALA B O 1 ATOM 817 C CB . ALA A 1 171 ? -27.876 -23.328 22.654 1.00 42.18 ? 144 ALA B CB 1 ATOM 818 N N . THR A 1 172 ? -29.892 -21.676 23.884 1.00 42.84 ? 145 THR B N 1 ATOM 819 C CA . THR A 1 172 ? -31.111 -21.302 24.607 1.00 39.01 ? 145 THR B CA 1 ATOM 820 C C . THR A 1 172 ? -31.929 -22.515 25.063 1.00 43.31 ? 145 THR B C 1 ATOM 821 O O . THR A 1 172 ? -32.118 -22.734 26.264 1.00 54.76 ? 145 THR B O 1 ATOM 822 C CB . THR A 1 172 ? -31.984 -20.427 23.730 1.00 37.51 ? 145 THR B CB 1 ATOM 823 O OG1 . THR A 1 172 ? -31.230 -19.283 23.328 1.00 38.78 ? 145 THR B OG1 1 ATOM 824 C CG2 . THR A 1 172 ? -33.279 -19.976 24.448 1.00 38.30 ? 145 THR B CG2 1 ATOM 825 N N . GLY A 1 173 ? -32.438 -23.302 24.130 1.00 41.61 ? 146 GLY B N 1 ATOM 826 C CA . GLY A 1 173 ? -33.263 -24.445 24.498 1.00 35.80 ? 146 GLY B CA 1 ATOM 827 C C . GLY A 1 173 ? -32.388 -25.531 25.084 1.00 38.23 ? 146 GLY B C 1 ATOM 828 O O . GLY A 1 173 ? -31.311 -25.830 24.556 1.00 41.24 ? 146 GLY B O 1 ATOM 829 N N . SER A 1 174 ? -32.863 -26.151 26.156 1.00 37.52 ? 147 SER B N 1 ATOM 830 C CA . SER A 1 174 ? -32.115 -27.170 26.845 1.00 38.49 ? 147 SER B CA 1 ATOM 831 C C . SER A 1 174 ? -31.760 -28.366 25.957 1.00 40.10 ? 147 SER B C 1 ATOM 832 O O . SER A 1 174 ? -30.704 -28.946 26.125 1.00 39.14 ? 147 SER B O 1 ATOM 833 C CB . SER A 1 174 ? -32.899 -27.651 28.060 1.00 40.52 ? 147 SER B CB 1 ATOM 834 O OG . SER A 1 174 ? -32.717 -26.767 29.165 1.00 41.57 ? 147 SER B OG 1 ATOM 835 N N . GLY A 1 175 ? -32.644 -28.732 25.032 1.00 41.72 ? 148 GLY B N 1 ATOM 836 C CA . GLY A 1 175 ? -32.377 -29.800 24.095 1.00 39.31 ? 148 GLY B CA 1 ATOM 837 C C . GLY A 1 175 ? -31.229 -29.474 23.168 1.00 45.17 ? 148 GLY B C 1 ATOM 838 O O . GLY A 1 175 ? -30.405 -30.350 22.811 1.00 49.58 ? 148 GLY B O 1 ATOM 839 N N . VAL A 1 176 ? -31.148 -28.203 22.772 1.00 48.68 ? 149 VAL B N 1 ATOM 840 C CA . VAL A 1 176 ? -30.063 -27.714 21.896 1.00 38.50 ? 149 VAL B CA 1 ATOM 841 C C . VAL A 1 176 ? -28.738 -27.684 22.655 1.00 37.16 ? 149 VAL B C 1 ATOM 842 O O . VAL A 1 176 ? -27.713 -28.179 22.173 1.00 33.40 ? 149 VAL B O 1 ATOM 843 C CB . VAL A 1 176 ? -30.425 -26.329 21.375 1.00 38.11 ? 149 VAL B CB 1 ATOM 844 C CG1 . VAL A 1 176 ? -29.257 -25.664 20.655 1.00 43.18 ? 149 VAL B CG1 1 ATOM 845 C CG2 . VAL A 1 176 ? -31.588 -26.439 20.405 1.00 40.91 ? 149 VAL B CG2 1 ATOM 846 N N . SER A 1 177 ? -28.768 -27.099 23.852 1.00 36.49 ? 150 SER B N 1 ATOM 847 C CA . SER A 1 177 ? -27.595 -27.084 24.738 1.00 37.23 ? 150 SER B CA 1 ATOM 848 C C . SER A 1 177 ? -27.061 -28.479 25.052 1.00 37.34 ? 150 SER B C 1 ATOM 849 O O . SER A 1 177 ? -25.869 -28.659 25.186 1.00 35.81 ? 150 SER B O 1 ATOM 850 C CB . SER A 1 177 ? -27.916 -26.364 26.046 1.00 38.35 ? 150 SER B CB 1 ATOM 851 O OG . SER A 1 177 ? -27.829 -24.969 25.891 1.00 40.67 ? 150 SER B OG 1 ATOM 852 N N . THR A 1 178 ? -27.955 -29.453 25.164 1.00 38.70 ? 151 THR B N 1 ATOM 853 C CA . THR A 1 178 ? -27.563 -30.811 25.413 1.00 40.13 ? 151 THR B CA 1 ATOM 854 C C . THR A 1 178 ? -26.742 -31.353 24.291 1.00 41.38 ? 151 THR B C 1 ATOM 855 O O . THR A 1 178 ? -25.680 -31.880 24.513 1.00 43.37 ? 151 THR B O 1 ATOM 856 C CB . THR A 1 178 ? -28.771 -31.715 25.562 1.00 43.12 ? 151 THR B CB 1 ATOM 857 O OG1 . THR A 1 178 ? -29.387 -31.411 26.792 1.00 42.10 ? 151 THR B OG1 1 ATOM 858 C CG2 . THR A 1 178 ? -28.356 -33.168 25.603 1.00 46.10 ? 151 THR B CG2 1 ATOM 859 N N . ALA A 1 179 ? -27.238 -31.231 23.074 1.00 46.83 ? 152 ALA B N 1 ATOM 860 C CA . ALA A 1 179 ? -26.496 -31.724 21.922 1.00 46.18 ? 152 ALA B CA 1 ATOM 861 C C . ALA A 1 179 ? -25.176 -31.004 21.801 1.00 46.33 ? 152 ALA B C 1 ATOM 862 O O . ALA A 1 179 ? -24.183 -31.601 21.453 1.00 54.16 ? 152 ALA B O 1 ATOM 863 C CB . ALA A 1 179 ? -27.291 -31.556 20.641 1.00 44.37 ? 152 ALA B CB 1 ATOM 864 N N . VAL A 1 180 ? -25.157 -29.717 22.072 1.00 48.45 ? 153 VAL B N 1 ATOM 865 C CA . VAL A 1 180 ? -23.923 -28.945 21.877 1.00 50.41 ? 153 VAL B CA 1 ATOM 866 C C . VAL A 1 180 ? -22.894 -29.373 22.909 1.00 48.33 ? 153 VAL B C 1 ATOM 867 O O . VAL A 1 180 ? -21.734 -29.588 22.583 1.00 48.65 ? 153 VAL B O 1 ATOM 868 C CB . VAL A 1 180 ? -24.225 -27.445 21.956 1.00 49.41 ? 153 VAL B CB 1 ATOM 869 C CG1 . VAL A 1 180 ? -22.990 -26.630 22.196 1.00 50.81 ? 153 VAL B CG1 1 ATOM 870 C CG2 . VAL A 1 180 ? -24.844 -27.020 20.651 1.00 54.85 ? 153 VAL B CG2 1 ATOM 871 N N . ALA A 1 181 ? -23.357 -29.514 24.143 1.00 45.36 ? 154 ALA B N 1 ATOM 872 C CA . ALA A 1 181 ? -22.554 -29.943 25.268 1.00 43.85 ? 154 ALA B CA 1 ATOM 873 C C . ALA A 1 181 ? -21.934 -31.326 25.077 1.00 44.00 ? 154 ALA B C 1 ATOM 874 O O . ALA A 1 181 ? -20.841 -31.585 25.518 1.00 40.84 ? 154 ALA B O 1 ATOM 875 C CB . ALA A 1 181 ? -23.429 -29.971 26.513 1.00 46.33 ? 154 ALA B CB 1 ATOM 876 N N . ASN A 1 182 ? -22.663 -32.238 24.463 1.00 45.63 ? 155 ASN B N 1 ATOM 877 C CA . ASN A 1 182 ? -22.123 -33.528 24.211 1.00 46.05 ? 155 ASN B CA 1 ATOM 878 C C . ASN A 1 182 ? -20.874 -33.373 23.370 1.00 47.45 ? 155 ASN B C 1 ATOM 879 O O . ASN A 1 182 ? -19.894 -34.090 23.574 1.00 49.12 ? 155 ASN B O 1 ATOM 880 C CB . ASN A 1 182 ? -23.148 -34.404 23.504 1.00 50.57 ? 155 ASN B CB 1 ATOM 881 C CG . ASN A 1 182 ? -24.140 -35.031 24.458 1.00 52.51 ? 155 ASN B CG 1 ATOM 882 O OD1 . ASN A 1 182 ? -23.863 -35.210 25.652 1.00 58.08 ? 155 ASN B OD1 1 ATOM 883 N ND2 . ASN A 1 182 ? -25.302 -35.388 23.933 1.00 54.18 ? 155 ASN B ND2 1 ATOM 884 N N . LEU A 1 183 ? -20.900 -32.408 22.461 1.00 48.93 ? 156 LEU B N 1 ATOM 885 C CA . LEU A 1 183 ? -19.757 -32.136 21.582 1.00 52.59 ? 156 LEU B CA 1 ATOM 886 C C . LEU A 1 183 ? -18.615 -31.361 22.216 1.00 50.52 ? 156 LEU B C 1 ATOM 887 O O . LEU A 1 183 ? -17.490 -31.816 22.245 1.00 55.06 ? 156 LEU B O 1 ATOM 888 C CB . LEU A 1 183 ? -20.204 -31.399 20.320 1.00 51.83 ? 156 LEU B CB 1 ATOM 889 C CG . LEU A 1 183 ? -19.823 -32.185 19.089 1.00 55.19 ? 156 LEU B CG 1 ATOM 890 C CD1 . LEU A 1 183 ? -20.283 -31.454 17.860 1.00 61.49 ? 156 LEU B CD1 1 ATOM 891 C CD2 . LEU A 1 183 ? -18.323 -32.403 19.055 1.00 59.99 ? 156 LEU B CD2 1 ATOM 892 N N . LEU A 1 184 ? -18.898 -30.171 22.700 1.00 52.41 ? 157 LEU B N 1 ATOM 893 C CA . LEU A 1 184 ? -17.866 -29.351 23.304 1.00 50.77 ? 157 LEU B CA 1 ATOM 894 C C . LEU A 1 184 ? -17.212 -30.093 24.451 1.00 51.01 ? 157 LEU B C 1 ATOM 895 O O . LEU A 1 184 ? -16.021 -29.943 24.721 1.00 54.76 ? 157 LEU B O 1 ATOM 896 C CB . LEU A 1 184 ? -18.483 -28.067 23.845 1.00 47.94 ? 157 LEU B CB 1 ATOM 897 C CG . LEU A 1 184 ? -19.151 -27.185 22.815 1.00 45.38 ? 157 LEU B CG 1 ATOM 898 C CD1 . LEU A 1 184 ? -19.798 -26.021 23.535 1.00 48.13 ? 157 LEU B CD1 1 ATOM 899 C CD2 . LEU A 1 184 ? -18.148 -26.703 21.784 1.00 46.14 ? 157 LEU B CD2 1 ATOM 900 N N . GLY A 1 185 ? -18.007 -30.887 25.147 1.00 47.33 ? 158 GLY B N 1 ATOM 901 C CA . GLY A 1 185 ? -17.491 -31.654 26.264 1.00 48.88 ? 158 GLY B CA 1 ATOM 902 C C . GLY A 1 185 ? -16.373 -32.606 25.923 1.00 44.55 ? 158 GLY B C 1 ATOM 903 O O . GLY A 1 185 ? -15.529 -32.878 26.733 1.00 45.55 ? 158 GLY B O 1 ATOM 904 N N . LEU A 1 186 ? -16.380 -33.131 24.719 1.00 49.83 ? 159 LEU B N 1 ATOM 905 C CA . LEU A 1 186 ? -15.260 -33.926 24.251 1.00 55.86 ? 159 LEU B CA 1 ATOM 906 C C . LEU A 1 186 ? -13.898 -33.206 24.298 1.00 56.22 ? 159 LEU B C 1 ATOM 907 O O . LEU A 1 186 ? -12.894 -33.860 24.456 1.00 63.05 ? 159 LEU B O 1 ATOM 908 C CB . LEU A 1 186 ? -15.492 -34.337 22.820 1.00 57.88 ? 159 LEU B CB 1 ATOM 909 C CG . LEU A 1 186 ? -16.587 -35.347 22.630 1.00 60.88 ? 159 LEU B CG 1 ATOM 910 C CD1 . LEU A 1 186 ? -16.818 -35.500 21.139 1.00 62.98 ? 159 LEU B CD1 1 ATOM 911 C CD2 . LEU A 1 186 ? -16.180 -36.667 23.266 1.00 69.12 ? 159 LEU B CD2 1 ATOM 912 N N . PHE A 1 187 ? -13.877 -31.886 24.143 1.00 51.72 ? 160 PHE B N 1 ATOM 913 C CA . PHE A 1 187 ? -12.643 -31.116 23.991 1.00 48.17 ? 160 PHE B CA 1 ATOM 914 C C . PHE A 1 187 ? -12.477 -30.193 25.152 1.00 44.99 ? 160 PHE B C 1 ATOM 915 O O . PHE A 1 187 ? -11.671 -29.289 25.126 1.00 51.25 ? 160 PHE B O 1 ATOM 916 C CB . PHE A 1 187 ? -12.734 -30.308 22.697 1.00 50.16 ? 160 PHE B CB 1 ATOM 917 C CG . PHE A 1 187 ? -13.005 -31.171 21.508 1.00 56.62 ? 160 PHE B CG 1 ATOM 918 C CD1 . PHE A 1 187 ? -12.123 -32.216 21.191 1.00 61.60 ? 160 PHE B CD1 1 ATOM 919 C CD2 . PHE A 1 187 ? -14.144 -31.016 20.761 1.00 54.20 ? 160 PHE B CD2 1 ATOM 920 C CE1 . PHE A 1 187 ? -12.363 -33.058 20.122 1.00 64.21 ? 160 PHE B CE1 1 ATOM 921 C CE2 . PHE A 1 187 ? -14.390 -31.854 19.685 1.00 63.55 ? 160 PHE B CE2 1 ATOM 922 C CZ . PHE A 1 187 ? -13.504 -32.878 19.362 1.00 64.85 ? 160 PHE B CZ 1 ATOM 923 N N . TYR A 1 188 ? -13.279 -30.401 26.172 1.00 43.22 ? 161 TYR B N 1 ATOM 924 C CA . TYR A 1 188 ? -13.220 -29.583 27.371 1.00 43.70 ? 161 TYR B CA 1 ATOM 925 C C . TYR A 1 188 ? -13.367 -28.116 27.070 1.00 41.57 ? 161 TYR B C 1 ATOM 926 O O . TYR A 1 188 ? -12.825 -27.284 27.735 1.00 51.21 ? 161 TYR B O 1 ATOM 927 C CB . TYR A 1 188 ? -11.975 -29.927 28.213 1.00 41.94 ? 161 TYR B CB 1 ATOM 928 C CG . TYR A 1 188 ? -12.079 -31.336 28.769 1.00 43.44 ? 161 TYR B CG 1 ATOM 929 C CD1 . TYR A 1 188 ? -11.607 -32.446 28.029 1.00 43.02 ? 161 TYR B CD1 1 ATOM 930 C CD2 . TYR A 1 188 ? -12.713 -31.573 29.989 1.00 41.01 ? 161 TYR B CD2 1 ATOM 931 C CE1 . TYR A 1 188 ? -11.743 -33.745 28.506 1.00 45.69 ? 161 TYR B CE1 1 ATOM 932 C CE2 . TYR A 1 188 ? -12.858 -32.869 30.485 1.00 45.41 ? 161 TYR B CE2 1 ATOM 933 C CZ . TYR A 1 188 ? -12.378 -33.963 29.754 1.00 51.96 ? 161 TYR B CZ 1 ATOM 934 O OH . TYR A 1 188 ? -12.526 -35.263 30.270 1.00 51.06 ? 161 TYR B OH 1 ATOM 935 N N . ILE A 1 189 ? -14.184 -27.789 26.096 1.00 42.67 ? 162 ILE B N 1 ATOM 936 C CA . ILE A 1 189 ? -14.423 -26.392 25.792 1.00 42.05 ? 162 ILE B CA 1 ATOM 937 C C . ILE A 1 189 ? -15.514 -25.850 26.676 1.00 39.57 ? 162 ILE B C 1 ATOM 938 O O . ILE A 1 189 ? -16.651 -26.243 26.562 1.00 43.79 ? 162 ILE B O 1 ATOM 939 C CB . ILE A 1 189 ? -14.792 -26.244 24.322 1.00 42.13 ? 162 ILE B CB 1 ATOM 940 C CG1 . ILE A 1 189 ? -13.593 -26.697 23.504 1.00 44.23 ? 162 ILE B CG1 1 ATOM 941 C CG2 . ILE A 1 189 ? -15.103 -24.798 23.998 1.00 44.33 ? 162 ILE B CG2 1 ATOM 942 C CD1 . ILE A 1 189 ? -13.735 -26.464 22.026 1.00 48.66 ? 162 ILE B CD1 1 ATOM 943 N N . PRO A 1 190 ? -15.186 -24.956 27.579 1.00 38.99 ? 163 PRO B N 1 ATOM 944 C CA . PRO A 1 190 ? -16.281 -24.436 28.431 1.00 41.56 ? 163 PRO B CA 1 ATOM 945 C C . PRO A 1 190 ? -17.456 -23.860 27.654 1.00 40.22 ? 163 PRO B C 1 ATOM 946 O O . PRO A 1 190 ? -17.249 -23.174 26.659 1.00 42.76 ? 163 PRO B O 1 ATOM 947 C CB . PRO A 1 190 ? -15.623 -23.305 29.206 1.00 40.90 ? 163 PRO B CB 1 ATOM 948 C CG . PRO A 1 190 ? -14.488 -22.884 28.346 1.00 40.23 ? 163 PRO B CG 1 ATOM 949 C CD . PRO A 1 190 ? -13.996 -24.116 27.628 1.00 39.14 ? 163 PRO B CD 1 ATOM 950 N N . GLN A 1 191 ? -18.668 -24.161 28.118 1.00 39.42 ? 164 GLN B N 1 ATOM 951 C CA . GLN A 1 191 ? -19.909 -23.663 27.552 1.00 36.05 ? 164 GLN B CA 1 ATOM 952 C C . GLN A 1 191 ? -20.758 -23.029 28.674 1.00 38.74 ? 164 GLN B C 1 ATOM 953 O O . GLN A 1 191 ? -21.063 -23.667 29.660 1.00 37.40 ? 164 GLN B O 1 ATOM 954 C CB . GLN A 1 191 ? -20.659 -24.828 26.955 1.00 36.94 ? 164 GLN B CB 1 ATOM 955 C CG . GLN A 1 191 ? -21.968 -24.464 26.252 1.00 37.86 ? 164 GLN B CG 1 ATOM 956 C CD . GLN A 1 191 ? -22.806 -25.660 25.864 1.00 36.06 ? 164 GLN B CD 1 ATOM 957 O OE1 . GLN A 1 191 ? -22.312 -26.771 25.717 1.00 42.14 ? 164 GLN B OE1 1 ATOM 958 N NE2 . GLN A 1 191 ? -24.091 -25.437 25.695 1.00 40.77 ? 164 GLN B NE2 1 ATOM 959 N N . VAL A 1 192 ? -21.152 -21.774 28.515 1.00 40.34 ? 165 VAL B N 1 ATOM 960 C CA . VAL A 1 192 ? -21.916 -21.071 29.539 1.00 39.33 ? 165 VAL B CA 1 ATOM 961 C C . VAL A 1 192 ? -23.250 -20.673 28.913 1.00 40.30 ? 165 VAL B C 1 ATOM 962 O O . VAL A 1 192 ? -23.272 -19.787 28.074 1.00 42.41 ? 165 VAL B O 1 ATOM 963 C CB . VAL A 1 192 ? -21.208 -19.778 29.981 1.00 40.56 ? 165 VAL B CB 1 ATOM 964 C CG1 . VAL A 1 192 ? -21.947 -19.137 31.136 1.00 41.43 ? 165 VAL B CG1 1 ATOM 965 C CG2 . VAL A 1 192 ? -19.774 -20.044 30.362 1.00 41.31 ? 165 VAL B CG2 1 ATOM 966 N N . SER A 1 193 ? -24.349 -21.310 29.318 1.00 39.91 ? 166 SER B N 1 ATOM 967 C CA . SER A 1 193 ? -25.660 -20.998 28.784 1.00 39.09 ? 166 SER B CA 1 ATOM 968 C C . SER A 1 193 ? -26.367 -19.921 29.568 1.00 37.08 ? 166 SER B C 1 ATOM 969 O O . SER A 1 193 ? -26.342 -19.924 30.786 1.00 39.84 ? 166 SER B O 1 ATOM 970 C CB . SER A 1 193 ? -26.549 -22.252 28.732 1.00 42.09 ? 166 SER B CB 1 ATOM 971 O OG . SER A 1 193 ? -27.867 -21.951 28.197 1.00 40.96 ? 166 SER B OG 1 ATOM 972 N N . TYR A 1 194 ? -27.051 -19.050 28.842 1.00 38.78 ? 167 TYR B N 1 ATOM 973 C CA . TYR A 1 194 ? -27.851 -17.931 29.389 1.00 42.10 ? 167 TYR B CA 1 ATOM 974 C C . TYR A 1 194 ? -29.314 -18.303 29.629 1.00 42.25 ? 167 TYR B C 1 ATOM 975 O O . TYR A 1 194 ? -30.048 -17.594 30.327 1.00 45.95 ? 167 TYR B O 1 ATOM 976 C CB . TYR A 1 194 ? -27.808 -16.703 28.464 1.00 42.66 ? 167 TYR B CB 1 ATOM 977 C CG . TYR A 1 194 ? -27.974 -17.071 27.012 1.00 44.98 ? 167 TYR B CG 1 ATOM 978 C CD1 . TYR A 1 194 ? -29.219 -17.201 26.460 1.00 42.07 ? 167 TYR B CD1 1 ATOM 979 C CD2 . TYR A 1 194 ? -26.867 -17.349 26.212 1.00 48.66 ? 167 TYR B CD2 1 ATOM 980 C CE1 . TYR A 1 194 ? -29.379 -17.568 25.142 1.00 47.14 ? 167 TYR B CE1 1 ATOM 981 C CE2 . TYR A 1 194 ? -27.023 -17.741 24.882 1.00 47.30 ? 167 TYR B CE2 1 ATOM 982 C CZ . TYR A 1 194 ? -28.287 -17.842 24.355 1.00 47.21 ? 167 TYR B CZ 1 ATOM 983 O OH . TYR A 1 194 ? -28.486 -18.199 23.038 1.00 50.97 ? 167 TYR B OH 1 ATOM 984 N N . ALA A 1 195 ? -29.758 -19.399 29.052 1.00 41.94 ? 168 ALA B N 1 ATOM 985 C CA . ALA A 1 195 ? -31.147 -19.754 29.213 1.00 39.81 ? 168 ALA B CA 1 ATOM 986 C C . ALA A 1 195 ? -31.503 -21.235 29.387 1.00 39.76 ? 168 ALA B C 1 ATOM 987 O O . ALA A 1 195 ? -32.631 -21.515 29.711 1.00 43.04 ? 168 ALA B O 1 ATOM 988 C CB . ALA A 1 195 ? -31.917 -19.147 28.069 1.00 42.19 ? 168 ALA B CB 1 ATOM 989 N N . SER A 1 196 ? -30.583 -22.188 29.224 1.00 40.64 ? 169 SER B N 1 ATOM 990 C CA . SER A 1 196 ? -30.977 -23.613 29.257 1.00 43.87 ? 169 SER B CA 1 ATOM 991 C C . SER A 1 196 ? -31.094 -24.139 30.675 1.00 43.52 ? 169 SER B C 1 ATOM 992 O O . SER A 1 196 ? -30.102 -24.254 31.345 1.00 44.66 ? 169 SER B O 1 ATOM 993 C CB . SER A 1 196 ? -29.954 -24.453 28.517 1.00 44.49 ? 169 SER B CB 1 ATOM 994 O OG . SER A 1 196 ? -29.829 -24.001 27.195 1.00 44.51 ? 169 SER B OG 1 ATOM 995 N N . SER A 1 197 ? -32.291 -24.480 31.126 1.00 43.58 ? 170 SER B N 1 ATOM 996 C CA . SER A 1 197 ? -32.539 -24.667 32.569 1.00 43.05 ? 170 SER B CA 1 ATOM 997 C C . SER A 1 197 ? -32.905 -26.077 32.972 1.00 40.60 ? 170 SER B C 1 ATOM 998 O O . SER A 1 197 ? -33.247 -26.299 34.121 1.00 38.83 ? 170 SER B O 1 ATOM 999 C CB . SER A 1 197 ? -33.652 -23.732 33.033 1.00 45.28 ? 170 SER B CB 1 ATOM 1000 O OG . SER A 1 197 ? -34.785 -23.838 32.171 1.00 46.24 ? 170 SER B OG 1 ATOM 1001 N N . SER A 1 198 ? -32.773 -27.044 32.076 1.00 40.77 ? 171 SER B N 1 ATOM 1002 C CA . SER A 1 198 ? -33.118 -28.401 32.452 1.00 42.30 ? 171 SER B CA 1 ATOM 1003 C C . SER A 1 198 ? -32.200 -28.894 33.524 1.00 44.68 ? 171 SER B C 1 ATOM 1004 O O . SER A 1 198 ? -31.016 -28.657 33.477 1.00 46.41 ? 171 SER B O 1 ATOM 1005 C CB . SER A 1 198 ? -32.983 -29.362 31.302 1.00 43.52 ? 171 SER B CB 1 ATOM 1006 O OG . SER A 1 198 ? -33.181 -30.674 31.778 1.00 37.13 ? 171 SER B OG 1 ATOM 1007 N N . ARG A 1 199 ? -32.753 -29.607 34.489 1.00 47.10 ? 172 ARG B N 1 ATOM 1008 C CA . ARG A 1 199 ? -31.938 -30.233 35.525 1.00 46.53 ? 172 ARG B CA 1 ATOM 1009 C C . ARG A 1 199 ? -30.954 -31.245 34.918 1.00 44.91 ? 172 ARG B C 1 ATOM 1010 O O . ARG A 1 199 ? -29.978 -31.603 35.550 1.00 52.81 ? 172 ARG B O 1 ATOM 1011 C CB . ARG A 1 199 ? -32.835 -30.968 36.540 1.00 44.83 ? 172 ARG B CB 1 ATOM 1012 C CG . ARG A 1 199 ? -33.390 -32.265 36.004 1.00 43.94 ? 172 ARG B CG 1 ATOM 1013 C CD . ARG A 1 199 ? -33.897 -33.188 37.084 1.00 45.94 ? 172 ARG B CD 1 ATOM 1014 N NE . ARG A 1 199 ? -34.395 -34.475 36.546 1.00 46.53 ? 172 ARG B NE 1 ATOM 1015 C CZ . ARG A 1 199 ? -33.642 -35.555 36.282 1.00 42.63 ? 172 ARG B CZ 1 ATOM 1016 N NH1 . ARG A 1 199 ? -32.356 -35.559 36.466 1.00 40.78 ? 172 ARG B NH1 1 ATOM 1017 N NH2 . ARG A 1 199 ? -34.193 -36.645 35.808 1.00 46.25 ? 172 ARG B NH2 1 ATOM 1018 N N . LEU A 1 200 ? -31.231 -31.724 33.714 1.00 41.41 ? 173 LEU B N 1 ATOM 1019 C CA . LEU A 1 200 ? -30.450 -32.765 33.124 1.00 40.91 ? 173 LEU B CA 1 ATOM 1020 C C . LEU A 1 200 ? -29.048 -32.260 32.914 1.00 41.71 ? 173 LEU B C 1 ATOM 1021 O O . LEU A 1 200 ? -28.091 -33.002 33.077 1.00 41.68 ? 173 LEU B O 1 ATOM 1022 C CB . LEU A 1 200 ? -31.078 -33.199 31.801 1.00 45.22 ? 173 LEU B CB 1 ATOM 1023 C CG . LEU A 1 200 ? -32.359 -34.027 31.959 1.00 52.97 ? 173 LEU B CG 1 ATOM 1024 C CD1 . LEU A 1 200 ? -32.980 -34.360 30.612 1.00 54.92 ? 173 LEU B CD1 1 ATOM 1025 C CD2 . LEU A 1 200 ? -32.117 -35.308 32.763 1.00 52.92 ? 173 LEU B CD2 1 ATOM 1026 N N . LEU A 1 201 ? -28.925 -30.978 32.609 1.00 39.20 ? 174 LEU B N 1 ATOM 1027 C CA . LEU A 1 201 ? -27.625 -30.390 32.404 1.00 43.91 ? 174 LEU B CA 1 ATOM 1028 C C . LEU A 1 201 ? -26.750 -30.218 33.661 1.00 45.76 ? 174 LEU B C 1 ATOM 1029 O O . LEU A 1 201 ? -25.575 -29.881 33.541 1.00 50.85 ? 174 LEU B O 1 ATOM 1030 C CB . LEU A 1 201 ? -27.775 -29.043 31.715 1.00 40.36 ? 174 LEU B CB 1 ATOM 1031 C CG . LEU A 1 201 ? -28.238 -29.194 30.305 1.00 38.77 ? 174 LEU B CG 1 ATOM 1032 C CD1 . LEU A 1 201 ? -28.823 -27.888 29.868 1.00 40.80 ? 174 LEU B CD1 1 ATOM 1033 C CD2 . LEU A 1 201 ? -27.051 -29.529 29.427 1.00 45.32 ? 174 LEU B CD2 1 ATOM 1034 N N . SER A 1 202 ? -27.298 -30.411 34.848 1.00 46.58 ? 175 SER B N 1 ATOM 1035 C CA . SER A 1 202 ? -26.480 -30.354 36.069 1.00 46.01 ? 175 SER B CA 1 ATOM 1036 C C . SER A 1 202 ? -25.563 -31.539 36.250 1.00 46.66 ? 175 SER B C 1 ATOM 1037 O O . SER A 1 202 ? -24.633 -31.494 37.053 1.00 48.15 ? 175 SER B O 1 ATOM 1038 C CB . SER A 1 202 ? -27.359 -30.262 37.285 1.00 45.62 ? 175 SER B CB 1 ATOM 1039 O OG . SER A 1 202 ? -27.796 -28.939 37.408 1.00 53.13 ? 175 SER B OG 1 ATOM 1040 N N . ASN A 1 203 ? -25.840 -32.613 35.529 1.00 47.18 ? 176 ASN B N 1 ATOM 1041 C CA . ASN A 1 203 ? -25.062 -33.818 35.655 1.00 47.59 ? 176 ASN B CA 1 ATOM 1042 C C . ASN A 1 203 ? -23.671 -33.627 35.063 1.00 50.29 ? 176 ASN B C 1 ATOM 1043 O O . ASN A 1 203 ? -23.530 -33.564 33.840 1.00 50.15 ? 176 ASN B O 1 ATOM 1044 C CB . ASN A 1 203 ? -25.794 -34.900 34.913 1.00 50.12 ? 176 ASN B CB 1 ATOM 1045 C CG . ASN A 1 203 ? -25.138 -36.247 35.017 1.00 50.41 ? 176 ASN B CG 1 ATOM 1046 O OD1 . ASN A 1 203 ? -25.752 -37.214 34.647 1.00 52.58 ? 176 ASN B OD1 1 ATOM 1047 N ND2 . ASN A 1 203 ? -23.919 -36.325 35.502 1.00 50.24 ? 176 ASN B ND2 1 ATOM 1048 N N . LYS A 1 204 ? -22.655 -33.554 35.926 1.00 51.43 ? 177 LYS B N 1 ATOM 1049 C CA . LYS A 1 204 ? -21.291 -33.265 35.477 1.00 57.31 ? 177 LYS B CA 1 ATOM 1050 C C . LYS A 1 204 ? -20.497 -34.484 34.937 1.00 59.94 ? 177 LYS B C 1 ATOM 1051 O O . LYS A 1 204 ? -19.432 -34.291 34.359 1.00 65.26 ? 177 LYS B O 1 ATOM 1052 C CB . LYS A 1 204 ? -20.478 -32.544 36.572 1.00 60.82 ? 177 LYS B CB 1 ATOM 1053 C CG . LYS A 1 204 ? -20.870 -31.092 36.927 1.00 63.95 ? 177 LYS B CG 1 ATOM 1054 C CD . LYS A 1 204 ? -21.033 -30.141 35.732 1.00 69.16 ? 177 LYS B CD 1 ATOM 1055 C CE . LYS A 1 204 ? -22.473 -30.146 35.164 1.00 65.91 ? 177 LYS B CE 1 ATOM 1056 N NZ . LYS A 1 204 ? -22.800 -28.950 34.344 1.00 62.18 ? 177 LYS B NZ 1 ATOM 1057 N N . ASN A 1 205 ? -20.966 -35.716 35.134 1.00 55.03 ? 178 ASN B N 1 ATOM 1058 C CA . ASN A 1 205 ? -20.377 -36.841 34.411 1.00 58.63 ? 178 ASN B CA 1 ATOM 1059 C C . ASN A 1 205 ? -20.696 -36.787 32.968 1.00 58.14 ? 178 ASN B C 1 ATOM 1060 O O . ASN A 1 205 ? -19.812 -37.006 32.149 1.00 65.34 ? 178 ASN B O 1 ATOM 1061 C CB . ASN A 1 205 ? -20.819 -38.206 34.931 1.00 65.62 ? 178 ASN B CB 1 ATOM 1062 C CG . ASN A 1 205 ? -20.337 -38.456 36.326 1.00 69.66 ? 178 ASN B CG 1 ATOM 1063 O OD1 . ASN A 1 205 ? -19.180 -38.166 36.647 1.00 79.95 ? 178 ASN B OD1 1 ATOM 1064 N ND2 . ASN A 1 205 ? -21.219 -38.957 37.180 1.00 72.34 ? 178 ASN B ND2 1 ATOM 1065 N N . GLN A 1 206 ? -21.950 -36.515 32.630 1.00 55.75 ? 179 GLN B N 1 ATOM 1066 C CA . GLN A 1 206 ? -22.284 -36.387 31.227 1.00 54.80 ? 179 GLN B CA 1 ATOM 1067 C C . GLN A 1 206 ? -21.825 -35.025 30.623 1.00 54.40 ? 179 GLN B C 1 ATOM 1068 O O . GLN A 1 206 ? -21.357 -34.981 29.503 1.00 56.76 ? 179 GLN B O 1 ATOM 1069 C CB . GLN A 1 206 ? -23.762 -36.641 30.991 1.00 56.84 ? 179 GLN B CB 1 ATOM 1070 C CG . GLN A 1 206 ? -24.117 -36.412 29.533 1.00 67.78 ? 179 GLN B CG 1 ATOM 1071 C CD . GLN A 1 206 ? -25.092 -37.388 28.909 1.00 76.08 ? 179 GLN B CD 1 ATOM 1072 O OE1 . GLN A 1 206 ? -25.698 -37.081 27.868 1.00 86.31 ? 179 GLN B OE1 1 ATOM 1073 N NE2 . GLN A 1 206 ? -25.215 -38.576 29.490 1.00 83.69 ? 179 GLN B NE2 1 ATOM 1074 N N . PHE A 1 207 ? -21.956 -33.924 31.350 1.00 53.64 ? 180 PHE B N 1 ATOM 1075 C CA . PHE A 1 207 ? -21.672 -32.606 30.786 1.00 50.81 ? 180 PHE B CA 1 ATOM 1076 C C . PHE A 1 207 ? -20.514 -31.942 31.538 1.00 49.56 ? 180 PHE B C 1 ATOM 1077 O O . PHE A 1 207 ? -20.686 -31.100 32.396 1.00 55.20 ? 180 PHE B O 1 ATOM 1078 C CB . PHE A 1 207 ? -22.925 -31.752 30.770 1.00 46.85 ? 180 PHE B CB 1 ATOM 1079 C CG . PHE A 1 207 ? -24.122 -32.445 30.185 1.00 44.13 ? 180 PHE B CG 1 ATOM 1080 C CD1 . PHE A 1 207 ? -24.226 -32.639 28.811 1.00 44.55 ? 180 PHE B CD1 1 ATOM 1081 C CD2 . PHE A 1 207 ? -25.177 -32.861 30.988 1.00 41.63 ? 180 PHE B CD2 1 ATOM 1082 C CE1 . PHE A 1 207 ? -25.346 -33.281 28.250 1.00 40.17 ? 180 PHE B CE1 1 ATOM 1083 C CE2 . PHE A 1 207 ? -26.289 -33.496 30.434 1.00 38.69 ? 180 PHE B CE2 1 ATOM 1084 C CZ . PHE A 1 207 ? -26.364 -33.722 29.070 1.00 37.42 ? 180 PHE B CZ 1 ATOM 1085 N N . LYS A 1 208 ? -19.320 -32.364 31.158 1.00 51.92 ? 181 LYS B N 1 ATOM 1086 C CA . LYS A 1 208 ? -18.051 -31.936 31.737 1.00 46.04 ? 181 LYS B CA 1 ATOM 1087 C C . LYS A 1 208 ? -17.741 -30.465 31.632 1.00 44.50 ? 181 LYS B C 1 ATOM 1088 O O . LYS A 1 208 ? -17.070 -29.948 32.512 1.00 49.11 ? 181 LYS B O 1 ATOM 1089 C CB . LYS A 1 208 ? -16.927 -32.704 31.044 1.00 47.99 ? 181 LYS B CB 1 ATOM 1090 C CG . LYS A 1 208 ? -16.889 -34.156 31.454 1.00 52.01 ? 181 LYS B CG 1 ATOM 1091 C CD . LYS A 1 208 ? -16.145 -34.986 30.449 1.00 66.10 ? 181 LYS B CD 1 ATOM 1092 C CE . LYS A 1 208 ? -16.162 -36.451 30.876 1.00 80.89 ? 181 LYS B CE 1 ATOM 1093 N NZ . LYS A 1 208 ? -15.086 -37.197 30.150 1.00 90.75 ? 181 LYS B NZ 1 ATOM 1094 N N . SER A 1 209 ? -18.188 -29.780 30.575 1.00 40.01 ? 182 SER B N 1 ATOM 1095 C CA . SER A 1 209 ? -17.803 -28.374 30.415 1.00 39.26 ? 182 SER B CA 1 ATOM 1096 C C . SER A 1 209 ? -18.965 -27.371 30.423 1.00 37.95 ? 182 SER B C 1 ATOM 1097 O O . SER A 1 209 ? -18.847 -26.253 29.915 1.00 38.26 ? 182 SER B O 1 ATOM 1098 C CB . SER A 1 209 ? -16.878 -28.166 29.192 1.00 37.29 ? 182 SER B CB 1 ATOM 1099 O OG . SER A 1 209 ? -17.562 -28.193 27.965 1.00 42.79 ? 182 SER B OG 1 ATOM 1100 N N . PHE A 1 210 ? -20.055 -27.740 31.060 1.00 36.57 ? 183 PHE B N 1 ATOM 1101 C CA . PHE A 1 210 ? -21.261 -26.943 30.966 1.00 38.47 ? 183 PHE B CA 1 ATOM 1102 C C . PHE A 1 210 ? -21.504 -26.152 32.242 1.00 36.51 ? 183 PHE B C 1 ATOM 1103 O O . PHE A 1 210 ? -21.503 -26.709 33.319 1.00 42.74 ? 183 PHE B O 1 ATOM 1104 C CB . PHE A 1 210 ? -22.484 -27.824 30.684 1.00 37.98 ? 183 PHE B CB 1 ATOM 1105 C CG . PHE A 1 210 ? -23.760 -27.046 30.575 1.00 39.98 ? 183 PHE B CG 1 ATOM 1106 C CD1 . PHE A 1 210 ? -24.593 -26.898 31.659 1.00 36.77 ? 183 PHE B CD1 1 ATOM 1107 C CD2 . PHE A 1 210 ? -24.112 -26.436 29.382 1.00 43.03 ? 183 PHE B CD2 1 ATOM 1108 C CE1 . PHE A 1 210 ? -25.776 -26.180 31.557 1.00 37.83 ? 183 PHE B CE1 1 ATOM 1109 C CE2 . PHE A 1 210 ? -25.299 -25.717 29.280 1.00 43.41 ? 183 PHE B CE2 1 ATOM 1110 C CZ . PHE A 1 210 ? -26.125 -25.597 30.379 1.00 40.68 ? 183 PHE B CZ 1 ATOM 1111 N N . LEU A 1 211 ? -21.701 -24.853 32.098 1.00 36.27 ? 184 LEU B N 1 ATOM 1112 C CA . LEU A 1 211 ? -22.192 -24.023 33.167 1.00 39.30 ? 184 LEU B CA 1 ATOM 1113 C C . LEU A 1 211 ? -23.263 -23.125 32.635 1.00 36.69 ? 184 LEU B C 1 ATOM 1114 O O . LEU A 1 211 ? -23.456 -23.013 31.454 1.00 39.48 ? 184 LEU B O 1 ATOM 1115 C CB . LEU A 1 211 ? -21.102 -23.137 33.732 1.00 44.95 ? 184 LEU B CB 1 ATOM 1116 C CG . LEU A 1 211 ? -19.751 -23.781 33.992 1.00 49.72 ? 184 LEU B CG 1 ATOM 1117 C CD1 . LEU A 1 211 ? -18.805 -23.433 32.861 1.00 48.98 ? 184 LEU B CD1 1 ATOM 1118 C CD2 . LEU A 1 211 ? -19.225 -23.286 35.331 1.00 54.59 ? 184 LEU B CD2 1 ATOM 1119 N N . ARG A 1 212 ? -23.953 -22.463 33.526 1.00 38.64 ? 185 ARG B N 1 ATOM 1120 C CA . ARG A 1 212 ? -25.002 -21.598 33.117 1.00 43.65 ? 185 ARG B CA 1 ATOM 1121 C C . ARG A 1 212 ? -25.188 -20.461 34.080 1.00 46.27 ? 185 ARG B C 1 ATOM 1122 O O . ARG A 1 212 ? -24.993 -20.625 35.293 1.00 43.08 ? 185 ARG B O 1 ATOM 1123 C CB . ARG A 1 212 ? -26.287 -22.395 32.998 1.00 45.14 ? 185 ARG B CB 1 ATOM 1124 C CG . ARG A 1 212 ? -26.690 -23.224 34.201 1.00 41.12 ? 185 ARG B CG 1 ATOM 1125 C CD . ARG A 1 212 ? -27.965 -23.983 33.831 1.00 40.83 ? 185 ARG B CD 1 ATOM 1126 N NE . ARG A 1 212 ? -28.143 -25.202 34.606 1.00 40.50 ? 185 ARG B NE 1 ATOM 1127 C CZ . ARG A 1 212 ? -28.984 -26.193 34.324 1.00 38.26 ? 185 ARG B CZ 1 ATOM 1128 N NH1 . ARG A 1 212 ? -29.788 -26.164 33.274 1.00 40.60 ? 185 ARG B NH1 1 ATOM 1129 N NH2 . ARG A 1 212 ? -29.019 -27.243 35.111 1.00 39.50 ? 185 ARG B NH2 1 ATOM 1130 N N . THR A 1 213 ? -25.584 -19.318 33.528 1.00 47.61 ? 186 THR B N 1 ATOM 1131 C CA . THR A 1 213 ? -25.915 -18.148 34.342 1.00 51.70 ? 186 THR B CA 1 ATOM 1132 C C . THR A 1 213 ? -27.394 -18.067 34.678 1.00 52.28 ? 186 THR B C 1 ATOM 1133 O O . THR A 1 213 ? -27.891 -16.991 34.974 1.00 57.80 ? 186 THR B O 1 ATOM 1134 C CB . THR A 1 213 ? -25.536 -16.869 33.608 1.00 52.90 ? 186 THR B CB 1 ATOM 1135 O OG1 . THR A 1 213 ? -26.110 -16.887 32.291 1.00 49.85 ? 186 THR B OG1 1 ATOM 1136 C CG2 . THR A 1 213 ? -24.049 -16.764 33.505 1.00 56.14 ? 186 THR B CG2 1 ATOM 1137 N N . ILE A 1 214 ? -28.095 -19.199 34.618 1.00 53.65 ? 187 ILE B N 1 ATOM 1138 C CA . ILE A 1 214 ? -29.535 -19.261 34.912 1.00 50.94 ? 187 ILE B CA 1 ATOM 1139 C C . ILE A 1 214 ? -29.755 -20.415 35.871 1.00 48.34 ? 187 ILE B C 1 ATOM 1140 O O . ILE A 1 214 ? -29.023 -21.405 35.821 1.00 58.76 ? 187 ILE B O 1 ATOM 1141 C CB . ILE A 1 214 ? -30.382 -19.455 33.623 1.00 54.82 ? 187 ILE B CB 1 ATOM 1142 C CG1 . ILE A 1 214 ? -31.868 -19.283 33.918 1.00 55.15 ? 187 ILE B CG1 1 ATOM 1143 C CG2 . ILE A 1 214 ? -30.178 -20.828 32.993 1.00 54.08 ? 187 ILE B CG2 1 ATOM 1144 C CD1 . ILE A 1 214 ? -32.766 -19.178 32.696 1.00 55.36 ? 187 ILE B CD1 1 ATOM 1145 N N . PRO A 1 215 ? -30.712 -20.286 36.792 1.00 45.41 ? 188 PRO B N 1 ATOM 1146 C CA . PRO A 1 215 ? -31.009 -21.403 37.721 1.00 44.81 ? 188 PRO B CA 1 ATOM 1147 C C . PRO A 1 215 ? -31.763 -22.532 37.064 1.00 43.33 ? 188 PRO B C 1 ATOM 1148 O O . PRO A 1 215 ? -32.590 -22.314 36.187 1.00 49.74 ? 188 PRO B O 1 ATOM 1149 C CB . PRO A 1 215 ? -31.939 -20.805 38.756 1.00 43.66 ? 188 PRO B CB 1 ATOM 1150 C CG . PRO A 1 215 ? -32.110 -19.362 38.402 1.00 45.41 ? 188 PRO B CG 1 ATOM 1151 C CD . PRO A 1 215 ? -31.405 -19.040 37.142 1.00 45.88 ? 188 PRO B CD 1 ATOM 1152 N N . ASN A 1 216 ? -31.498 -23.732 37.517 1.00 46.13 ? 189 ASN B N 1 ATOM 1153 C CA . ASN A 1 216 ? -32.164 -24.880 36.989 1.00 51.18 ? 189 ASN B CA 1 ATOM 1154 C C . ASN A 1 216 ? -33.607 -25.003 37.513 1.00 50.86 ? 189 ASN B C 1 ATOM 1155 O O . ASN A 1 216 ? -33.995 -24.418 38.539 1.00 42.01 ? 189 ASN B O 1 ATOM 1156 C CB . ASN A 1 216 ? -31.286 -26.134 37.187 1.00 58.79 ? 189 ASN B CB 1 ATOM 1157 C CG . ASN A 1 216 ? -31.709 -27.024 38.340 1.00 61.46 ? 189 ASN B CG 1 ATOM 1158 O OD1 . ASN A 1 216 ? -32.857 -27.038 38.755 1.00 67.43 ? 189 ASN B OD1 1 ATOM 1159 N ND2 . ASN A 1 216 ? -30.772 -27.846 38.808 1.00 65.11 ? 189 ASN B ND2 1 ATOM 1160 N N . ASP A 1 217 ? -34.388 -25.777 36.768 1.00 52.29 ? 190 ASP B N 1 ATOM 1161 C CA . ASP A 1 217 ? -35.827 -25.849 36.947 1.00 52.65 ? 190 ASP B CA 1 ATOM 1162 C C . ASP A 1 217 ? -36.337 -26.694 38.105 1.00 52.10 ? 190 ASP B C 1 ATOM 1163 O O . ASP A 1 217 ? -37.518 -26.694 38.361 1.00 57.96 ? 190 ASP B O 1 ATOM 1164 C CB . ASP A 1 217 ? -36.474 -26.307 35.647 1.00 52.93 ? 190 ASP B CB 1 ATOM 1165 C CG . ASP A 1 217 ? -36.447 -25.224 34.580 1.00 56.26 ? 190 ASP B CG 1 ATOM 1166 O OD1 . ASP A 1 217 ? -36.554 -24.011 34.910 1.00 58.43 ? 190 ASP B OD1 1 ATOM 1167 O OD2 . ASP A 1 217 ? -36.299 -25.595 33.404 1.00 62.11 ? 190 ASP B OD2 1 ATOM 1168 N N . GLU A 1 218 ? -35.477 -27.398 38.819 1.00 50.24 ? 191 GLU B N 1 ATOM 1169 C CA . GLU A 1 218 ? -35.916 -28.001 40.059 1.00 50.39 ? 191 GLU B CA 1 ATOM 1170 C C . GLU A 1 218 ? -36.599 -26.955 40.901 1.00 53.25 ? 191 GLU B C 1 ATOM 1171 O O . GLU A 1 218 ? -37.615 -27.255 41.534 1.00 54.85 ? 191 GLU B O 1 ATOM 1172 C CB . GLU A 1 218 ? -34.758 -28.596 40.856 1.00 54.25 ? 191 GLU B CB 1 ATOM 1173 C CG . GLU A 1 218 ? -34.057 -29.755 40.177 1.00 59.21 ? 191 GLU B CG 1 ATOM 1174 C CD . GLU A 1 218 ? -34.956 -30.974 39.969 1.00 59.98 ? 191 GLU B CD 1 ATOM 1175 O OE1 . GLU A 1 218 ? -34.751 -31.957 40.694 1.00 57.51 ? 191 GLU B OE1 1 ATOM 1176 O OE2 . GLU A 1 218 ? -35.848 -30.971 39.075 1.00 68.95 ? 191 GLU B OE2 1 ATOM 1177 N N . HIS A 1 219 ? -36.063 -25.732 40.916 1.00 48.18 ? 192 HIS B N 1 ATOM 1178 C CA . HIS A 1 219 ? -36.584 -24.717 41.818 1.00 51.56 ? 192 HIS B CA 1 ATOM 1179 C C . HIS A 1 219 ? -37.909 -24.140 41.345 1.00 51.04 ? 192 HIS B C 1 ATOM 1180 O O . HIS A 1 219 ? -38.848 -23.940 42.120 1.00 51.56 ? 192 HIS B O 1 ATOM 1181 C CB . HIS A 1 219 ? -35.568 -23.605 41.988 1.00 57.60 ? 192 HIS B CB 1 ATOM 1182 C CG . HIS A 1 219 ? -34.231 -24.098 42.423 1.00 62.71 ? 192 HIS B CG 1 ATOM 1183 N ND1 . HIS A 1 219 ? -34.030 -24.705 43.643 1.00 65.72 ? 192 HIS B ND1 1 ATOM 1184 C CD2 . HIS A 1 219 ? -33.035 -24.107 41.792 1.00 65.71 ? 192 HIS B CD2 1 ATOM 1185 C CE1 . HIS A 1 219 ? -32.762 -25.049 43.755 1.00 62.95 ? 192 HIS B CE1 1 ATOM 1186 N NE2 . HIS A 1 219 ? -32.140 -24.709 42.640 1.00 69.80 ? 192 HIS B NE2 1 ATOM 1187 N N . GLN A 1 220 ? -37.976 -23.909 40.049 1.00 52.36 ? 193 GLN B N 1 ATOM 1188 C CA . GLN A 1 220 ? -39.146 -23.316 39.432 1.00 53.02 ? 193 GLN B CA 1 ATOM 1189 C C . GLN A 1 220 ? -40.395 -24.180 39.635 1.00 47.51 ? 193 GLN B C 1 ATOM 1190 O O . GLN A 1 220 ? -41.467 -23.678 39.916 1.00 47.57 ? 193 GLN B O 1 ATOM 1191 C CB . GLN A 1 220 ? -38.883 -23.126 37.937 1.00 51.88 ? 193 GLN B CB 1 ATOM 1192 C CG . GLN A 1 220 ? -39.608 -21.940 37.381 1.00 52.13 ? 193 GLN B CG 1 ATOM 1193 C CD . GLN A 1 220 ? -39.818 -22.017 35.905 1.00 53.46 ? 193 GLN B CD 1 ATOM 1194 O OE1 . GLN A 1 220 ? -38.964 -22.483 35.135 1.00 64.98 ? 193 GLN B OE1 1 ATOM 1195 N NE2 . GLN A 1 220 ? -40.962 -21.563 35.490 1.00 49.98 ? 193 GLN B NE2 1 ATOM 1196 N N . ALA A 1 221 ? -40.213 -25.480 39.476 1.00 44.32 ? 194 ALA B N 1 ATOM 1197 C CA . ALA A 1 221 ? -41.254 -26.476 39.631 1.00 44.31 ? 194 ALA B CA 1 ATOM 1198 C C . ALA A 1 221 ? -41.709 -26.580 41.066 1.00 42.28 ? 194 ALA B C 1 ATOM 1199 O O . ALA A 1 221 ? -42.869 -26.835 41.333 1.00 50.80 ? 194 ALA B O 1 ATOM 1200 C CB . ALA A 1 221 ? -40.741 -27.853 39.169 1.00 45.33 ? 194 ALA B CB 1 ATOM 1201 N N . THR A 1 222 ? -40.788 -26.464 41.989 1.00 40.62 ? 195 THR B N 1 ATOM 1202 C CA . THR A 1 222 ? -41.148 -26.412 43.377 1.00 44.92 ? 195 THR B CA 1 ATOM 1203 C C . THR A 1 222 ? -41.950 -25.110 43.658 1.00 45.72 ? 195 THR B C 1 ATOM 1204 O O . THR A 1 222 ? -42.932 -25.139 44.380 1.00 43.63 ? 195 THR B O 1 ATOM 1205 C CB . THR A 1 222 ? -39.889 -26.462 44.270 1.00 45.16 ? 195 THR B CB 1 ATOM 1206 O OG1 . THR A 1 222 ? -39.124 -27.631 43.966 1.00 49.23 ? 195 THR B OG1 1 ATOM 1207 C CG2 . THR A 1 222 ? -40.286 -26.538 45.697 1.00 46.22 ? 195 THR B CG2 1 ATOM 1208 N N . ALA A 1 223 ? -41.526 -23.990 43.075 1.00 44.57 ? 196 ALA B N 1 ATOM 1209 C CA . ALA A 1 223 ? -42.239 -22.723 43.232 1.00 46.19 ? 196 ALA B CA 1 ATOM 1210 C C . ALA A 1 223 ? -43.662 -22.838 42.713 1.00 44.58 ? 196 ALA B C 1 ATOM 1211 O O . ALA A 1 223 ? -44.600 -22.445 43.402 1.00 44.63 ? 196 ALA B O 1 ATOM 1212 C CB . ALA A 1 223 ? -41.505 -21.586 42.525 1.00 46.13 ? 196 ALA B CB 1 ATOM 1213 N N . MET A 1 224 ? -43.832 -23.396 41.518 1.00 47.06 ? 197 MET B N 1 ATOM 1214 C CA . MET A 1 224 ? -45.174 -23.648 40.995 1.00 50.75 ? 197 MET B CA 1 ATOM 1215 C C . MET A 1 224 ? -46.069 -24.406 42.007 1.00 49.74 ? 197 MET B C 1 ATOM 1216 O O . MET A 1 224 ? -47.211 -24.027 42.272 1.00 45.79 ? 197 MET B O 1 ATOM 1217 C CB . MET A 1 224 ? -45.092 -24.392 39.683 1.00 56.67 ? 197 MET B CB 1 ATOM 1218 C CG . MET A 1 224 ? -45.168 -23.502 38.453 1.00 66.45 ? 197 MET B CG 1 ATOM 1219 S SD . MET A 1 224 ? -44.426 -24.311 36.996 1.00 83.55 ? 197 MET B SD 1 ATOM 1220 C CE . MET A 1 224 ? -44.895 -23.138 35.725 1.00 98.10 ? 197 MET B CE 1 ATOM 1221 N N . ALA A 1 225 ? -45.550 -25.465 42.602 1.00 49.17 ? 198 ALA B N 1 ATOM 1222 C CA . ALA A 1 225 ? -46.343 -26.186 43.582 1.00 49.37 ? 198 ALA B CA 1 ATOM 1223 C C . ALA A 1 225 ? -46.639 -25.336 44.834 1.00 50.78 ? 198 ALA B C 1 ATOM 1224 O O . ALA A 1 225 ? -47.724 -25.480 45.432 1.00 45.86 ? 198 ALA B O 1 ATOM 1225 C CB . ALA A 1 225 ? -45.674 -27.488 43.954 1.00 47.06 ? 198 ALA B CB 1 ATOM 1226 N N . ASP A 1 226 ? -45.690 -24.470 45.216 1.00 46.34 ? 199 ASP B N 1 ATOM 1227 C CA . ASP A 1 226 ? -45.874 -23.564 46.349 1.00 51.35 ? 199 ASP B CA 1 ATOM 1228 C C . ASP A 1 226 ? -46.933 -22.494 46.084 1.00 53.38 ? 199 ASP B C 1 ATOM 1229 O O . ASP A 1 226 ? -47.676 -22.145 46.990 1.00 56.86 ? 199 ASP B O 1 ATOM 1230 C CB . ASP A 1 226 ? -44.563 -22.874 46.764 1.00 53.85 ? 199 ASP B CB 1 ATOM 1231 C CG . ASP A 1 226 ? -43.650 -23.776 47.574 1.00 57.25 ? 199 ASP B CG 1 ATOM 1232 O OD1 . ASP A 1 226 ? -44.071 -24.911 47.895 1.00 54.81 ? 199 ASP B OD1 1 ATOM 1233 O OD2 . ASP A 1 226 ? -42.504 -23.357 47.887 1.00 66.00 ? 199 ASP B OD2 1 ATOM 1234 N N . ILE A 1 227 ? -46.988 -21.956 44.870 1.00 54.41 ? 200 ILE B N 1 ATOM 1235 C CA . ILE A 1 227 ? -48.056 -21.012 44.501 1.00 55.40 ? 200 ILE B CA 1 ATOM 1236 C C . ILE A 1 227 ? -49.431 -21.661 44.641 1.00 54.94 ? 200 ILE B C 1 ATOM 1237 O O . ILE A 1 227 ? -50.360 -21.090 45.252 1.00 59.93 ? 200 ILE B O 1 ATOM 1238 C CB . ILE A 1 227 ? -47.934 -20.516 43.049 1.00 60.53 ? 200 ILE B CB 1 ATOM 1239 C CG1 . ILE A 1 227 ? -46.730 -19.627 42.881 1.00 63.40 ? 200 ILE B CG1 1 ATOM 1240 C CG2 . ILE A 1 227 ? -49.133 -19.668 42.656 1.00 69.45 ? 200 ILE B CG2 1 ATOM 1241 C CD1 . ILE A 1 227 ? -46.744 -18.835 41.590 1.00 65.27 ? 200 ILE B CD1 1 ATOM 1242 N N . ILE A 1 228 ? -49.571 -22.843 44.064 1.00 48.70 ? 201 ILE B N 1 ATOM 1243 C CA . ILE A 1 228 ? -50.834 -23.553 44.152 1.00 49.77 ? 201 ILE B CA 1 ATOM 1244 C C . ILE A 1 228 ? -51.216 -23.756 45.625 1.00 45.40 ? 201 ILE B C 1 ATOM 1245 O O . ILE A 1 228 ? -52.297 -23.418 46.017 1.00 48.81 ? 201 ILE B O 1 ATOM 1246 C CB . ILE A 1 228 ? -50.793 -24.878 43.362 1.00 47.28 ? 201 ILE B CB 1 ATOM 1247 C CG1 . ILE A 1 228 ? -50.639 -24.590 41.878 1.00 51.05 ? 201 ILE B CG1 1 ATOM 1248 C CG2 . ILE A 1 228 ? -52.074 -25.665 43.532 1.00 47.50 ? 201 ILE B CG2 1 ATOM 1249 C CD1 . ILE A 1 228 ? -50.169 -25.781 41.066 1.00 54.28 ? 201 ILE B CD1 1 ATOM 1250 N N . GLU A 1 229 ? -50.316 -24.268 46.444 1.00 46.80 ? 202 GLU B N 1 ATOM 1251 C CA . GLU A 1 229 ? -50.595 -24.442 47.885 1.00 47.89 ? 202 GLU B CA 1 ATOM 1252 C C . GLU A 1 229 ? -50.941 -23.098 48.551 1.00 45.85 ? 202 GLU B C 1 ATOM 1253 O O . GLU A 1 229 ? -51.782 -23.045 49.412 1.00 51.59 ? 202 GLU B O 1 ATOM 1254 C CB . GLU A 1 229 ? -49.383 -25.085 48.572 1.00 50.39 ? 202 GLU B CB 1 ATOM 1255 C CG . GLU A 1 229 ? -49.551 -25.459 50.021 1.00 55.16 ? 202 GLU B CG 1 ATOM 1256 C CD . GLU A 1 229 ? -48.289 -26.004 50.688 1.00 59.58 ? 202 GLU B CD 1 ATOM 1257 O OE1 . GLU A 1 229 ? -48.436 -26.735 51.679 1.00 73.77 ? 202 GLU B OE1 1 ATOM 1258 O OE2 . GLU A 1 229 ? -47.154 -25.724 50.265 1.00 66.31 ? 202 GLU B OE2 1 ATOM 1259 N N . TYR A 1 230 ? -50.299 -22.019 48.132 1.00 48.35 ? 203 TYR B N 1 ATOM 1260 C CA . TYR A 1 230 ? -50.484 -20.694 48.714 1.00 50.53 ? 203 TYR B CA 1 ATOM 1261 C C . TYR A 1 230 ? -51.925 -20.259 48.647 1.00 49.92 ? 203 TYR B C 1 ATOM 1262 O O . TYR A 1 230 ? -52.449 -19.719 49.615 1.00 52.69 ? 203 TYR B O 1 ATOM 1263 C CB . TYR A 1 230 ? -49.622 -19.671 47.964 1.00 52.29 ? 203 TYR B CB 1 ATOM 1264 C CG . TYR A 1 230 ? -49.725 -18.241 48.483 1.00 54.30 ? 203 TYR B CG 1 ATOM 1265 C CD1 . TYR A 1 230 ? -48.974 -17.817 49.592 1.00 51.19 ? 203 TYR B CD1 1 ATOM 1266 C CD2 . TYR A 1 230 ? -50.523 -17.311 47.836 1.00 50.31 ? 203 TYR B CD2 1 ATOM 1267 C CE1 . TYR A 1 230 ? -49.059 -16.531 50.055 1.00 51.56 ? 203 TYR B CE1 1 ATOM 1268 C CE2 . TYR A 1 230 ? -50.607 -16.020 48.297 1.00 55.00 ? 203 TYR B CE2 1 ATOM 1269 C CZ . TYR A 1 230 ? -49.876 -15.635 49.403 1.00 54.51 ? 203 TYR B CZ 1 ATOM 1270 O OH . TYR A 1 230 ? -49.956 -14.333 49.833 1.00 57.36 ? 203 TYR B OH 1 ATOM 1271 N N . PHE A 1 231 ? -52.544 -20.517 47.496 1.00 48.61 ? 204 PHE B N 1 ATOM 1272 C CA . PHE A 1 231 ? -53.940 -20.194 47.244 1.00 47.58 ? 204 PHE B CA 1 ATOM 1273 C C . PHE A 1 231 ? -54.881 -21.286 47.688 1.00 48.65 ? 204 PHE B C 1 ATOM 1274 O O . PHE A 1 231 ? -56.076 -21.225 47.423 1.00 51.34 ? 204 PHE B O 1 ATOM 1275 C CB . PHE A 1 231 ? -54.166 -19.926 45.753 1.00 49.07 ? 204 PHE B CB 1 ATOM 1276 C CG . PHE A 1 231 ? -53.633 -18.603 45.318 1.00 54.65 ? 204 PHE B CG 1 ATOM 1277 C CD1 . PHE A 1 231 ? -54.315 -17.437 45.647 1.00 57.78 ? 204 PHE B CD1 1 ATOM 1278 C CD2 . PHE A 1 231 ? -52.431 -18.507 44.644 1.00 55.82 ? 204 PHE B CD2 1 ATOM 1279 C CE1 . PHE A 1 231 ? -53.833 -16.205 45.273 1.00 57.64 ? 204 PHE B CE1 1 ATOM 1280 C CE2 . PHE A 1 231 ? -51.939 -17.273 44.280 1.00 59.24 ? 204 PHE B CE2 1 ATOM 1281 C CZ . PHE A 1 231 ? -52.639 -16.118 44.590 1.00 56.26 ? 204 PHE B CZ 1 ATOM 1282 N N . ARG A 1 232 ? -54.351 -22.307 48.348 1.00 49.79 ? 205 ARG B N 1 ATOM 1283 C CA . ARG A 1 232 ? -55.171 -23.385 48.848 1.00 46.47 ? 205 ARG B CA 1 ATOM 1284 C C . ARG A 1 232 ? -55.912 -24.064 47.709 1.00 46.07 ? 205 ARG B C 1 ATOM 1285 O O . ARG A 1 232 ? -56.989 -24.584 47.917 1.00 49.54 ? 205 ARG B O 1 ATOM 1286 C CB . ARG A 1 232 ? -56.174 -22.848 49.878 1.00 46.92 ? 205 ARG B CB 1 ATOM 1287 C CG . ARG A 1 232 ? -55.682 -21.702 50.750 1.00 48.05 ? 205 ARG B CG 1 ATOM 1288 C CD . ARG A 1 232 ? -54.852 -22.174 51.917 1.00 53.84 ? 205 ARG B CD 1 ATOM 1289 N NE . ARG A 1 232 ? -54.382 -21.066 52.764 1.00 61.79 ? 205 ARG B NE 1 ATOM 1290 C CZ . ARG A 1 232 ? -53.685 -21.207 53.903 1.00 64.36 ? 205 ARG B CZ 1 ATOM 1291 N NH1 . ARG A 1 232 ? -53.378 -22.414 54.359 1.00 68.42 ? 205 ARG B NH1 1 ATOM 1292 N NH2 . ARG A 1 232 ? -53.302 -20.149 54.611 1.00 59.91 ? 205 ARG B NH2 1 ATOM 1293 N N . TRP A 1 233 ? -55.358 -24.051 46.500 1.00 48.46 ? 206 TRP B N 1 ATOM 1294 C CA . TRP A 1 233 ? -55.939 -24.829 45.407 1.00 48.44 ? 206 TRP B CA 1 ATOM 1295 C C . TRP A 1 233 ? -55.527 -26.276 45.565 1.00 46.48 ? 206 TRP B C 1 ATOM 1296 O O . TRP A 1 233 ? -54.550 -26.561 46.218 1.00 48.02 ? 206 TRP B O 1 ATOM 1297 C CB . TRP A 1 233 ? -55.465 -24.318 44.069 1.00 48.91 ? 206 TRP B CB 1 ATOM 1298 C CG . TRP A 1 233 ? -55.836 -22.924 43.800 1.00 51.97 ? 206 TRP B CG 1 ATOM 1299 C CD1 . TRP A 1 233 ? -56.872 -22.206 44.343 1.00 49.49 ? 206 TRP B CD1 1 ATOM 1300 C CD2 . TRP A 1 233 ? -55.185 -22.057 42.892 1.00 49.28 ? 206 TRP B CD2 1 ATOM 1301 N NE1 . TRP A 1 233 ? -56.881 -20.935 43.828 1.00 42.74 ? 206 TRP B NE1 1 ATOM 1302 C CE2 . TRP A 1 233 ? -55.849 -20.819 42.943 1.00 47.78 ? 206 TRP B CE2 1 ATOM 1303 C CE3 . TRP A 1 233 ? -54.087 -22.195 42.067 1.00 43.90 ? 206 TRP B CE3 1 ATOM 1304 C CZ2 . TRP A 1 233 ? -55.462 -19.751 42.182 1.00 49.94 ? 206 TRP B CZ2 1 ATOM 1305 C CZ3 . TRP A 1 233 ? -53.701 -21.132 41.325 1.00 46.07 ? 206 TRP B CZ3 1 ATOM 1306 C CH2 . TRP A 1 233 ? -54.383 -19.930 41.377 1.00 50.20 ? 206 TRP B CH2 1 ATOM 1307 N N . ASN A 1 234 ? -56.283 -27.192 44.989 1.00 50.94 ? 207 ASN B N 1 ATOM 1308 C CA . ASN A 1 234 ? -55.965 -28.610 45.119 1.00 51.08 ? 207 ASN B CA 1 ATOM 1309 C C . ASN A 1 234 ? -56.319 -29.458 43.912 1.00 51.93 ? 207 ASN B C 1 ATOM 1310 O O . ASN A 1 234 ? -56.409 -30.670 44.029 1.00 49.82 ? 207 ASN B O 1 ATOM 1311 C CB . ASN A 1 234 ? -56.742 -29.153 46.279 1.00 50.18 ? 207 ASN B CB 1 ATOM 1312 C CG . ASN A 1 234 ? -58.208 -29.184 45.994 1.00 53.67 ? 207 ASN B CG 1 ATOM 1313 O OD1 . ASN A 1 234 ? -58.641 -28.776 44.910 1.00 54.50 ? 207 ASN B OD1 1 ATOM 1314 N ND2 . ASN A 1 234 ? -58.996 -29.622 46.972 1.00 57.86 ? 207 ASN B ND2 1 ATOM 1315 N N . TRP A 1 235 ? -56.526 -28.814 42.768 1.00 53.39 ? 208 TRP B N 1 ATOM 1316 C CA . TRP A 1 235 ? -57.082 -29.466 41.606 1.00 53.75 ? 208 TRP B CA 1 ATOM 1317 C C . TRP A 1 235 ? -56.531 -28.727 40.411 1.00 58.32 ? 208 TRP B C 1 ATOM 1318 O O . TRP A 1 235 ? -56.869 -27.534 40.226 1.00 53.29 ? 208 TRP B O 1 ATOM 1319 C CB . TRP A 1 235 ? -58.592 -29.321 41.650 1.00 54.34 ? 208 TRP B CB 1 ATOM 1320 C CG . TRP A 1 235 ? -59.368 -30.019 40.597 1.00 57.43 ? 208 TRP B CG 1 ATOM 1321 C CD1 . TRP A 1 235 ? -60.238 -29.449 39.702 1.00 60.63 ? 208 TRP B CD1 1 ATOM 1322 C CD2 . TRP A 1 235 ? -59.409 -31.421 40.358 1.00 56.06 ? 208 TRP B CD2 1 ATOM 1323 N NE1 . TRP A 1 235 ? -60.788 -30.416 38.901 1.00 59.22 ? 208 TRP B NE1 1 ATOM 1324 C CE2 . TRP A 1 235 ? -60.307 -31.637 39.288 1.00 55.35 ? 208 TRP B CE2 1 ATOM 1325 C CE3 . TRP A 1 235 ? -58.772 -32.518 40.940 1.00 58.57 ? 208 TRP B CE3 1 ATOM 1326 C CZ2 . TRP A 1 235 ? -60.579 -32.902 38.785 1.00 57.43 ? 208 TRP B CZ2 1 ATOM 1327 C CZ3 . TRP A 1 235 ? -59.038 -33.796 40.434 1.00 60.93 ? 208 TRP B CZ3 1 ATOM 1328 C CH2 . TRP A 1 235 ? -59.935 -33.975 39.374 1.00 62.18 ? 208 TRP B CH2 1 ATOM 1329 N N . VAL A 1 236 ? -55.684 -29.419 39.622 1.00 53.83 ? 209 VAL B N 1 ATOM 1330 C CA . VAL A 1 236 ? -55.035 -28.814 38.439 1.00 55.30 ? 209 VAL B CA 1 ATOM 1331 C C . VAL A 1 236 ? -54.811 -29.775 37.262 1.00 50.64 ? 209 VAL B C 1 ATOM 1332 O O . VAL A 1 236 ? -54.826 -30.972 37.410 1.00 50.81 ? 209 VAL B O 1 ATOM 1333 C CB . VAL A 1 236 ? -53.641 -28.215 38.783 1.00 51.93 ? 209 VAL B CB 1 ATOM 1334 C CG1 . VAL A 1 236 ? -53.720 -27.293 39.969 1.00 53.93 ? 209 VAL B CG1 1 ATOM 1335 C CG2 . VAL A 1 236 ? -52.634 -29.310 39.090 1.00 50.17 ? 209 VAL B CG2 1 ATOM 1336 N N . GLY A 1 237 ? -54.542 -29.194 36.105 1.00 48.70 ? 210 GLY B N 1 ATOM 1337 C CA . GLY A 1 237 ? -54.071 -29.911 34.949 1.00 47.85 ? 210 GLY B CA 1 ATOM 1338 C C . GLY A 1 237 ? -52.659 -29.459 34.613 1.00 47.90 ? 210 GLY B C 1 ATOM 1339 O O . GLY A 1 237 ? -52.206 -28.376 35.056 1.00 46.23 ? 210 GLY B O 1 ATOM 1340 N N . THR A 1 238 ? -51.949 -30.315 33.874 1.00 43.91 ? 211 THR B N 1 ATOM 1341 C CA . THR A 1 238 ? -50.613 -29.994 33.405 1.00 44.95 ? 211 THR B CA 1 ATOM 1342 C C . THR A 1 238 ? -50.473 -30.279 31.947 1.00 45.45 ? 211 THR B C 1 ATOM 1343 O O . THR A 1 238 ? -51.073 -31.222 31.395 1.00 44.59 ? 211 THR B O 1 ATOM 1344 C CB . THR A 1 238 ? -49.541 -30.810 34.110 1.00 42.62 ? 211 THR B CB 1 ATOM 1345 O OG1 . THR A 1 238 ? -49.787 -32.190 33.857 1.00 49.27 ? 211 THR B OG1 1 ATOM 1346 C CG2 . THR A 1 238 ? -49.602 -30.560 35.610 1.00 43.12 ? 211 THR B CG2 1 ATOM 1347 N N . ILE A 1 239 ? -49.665 -29.447 31.321 1.00 44.32 ? 212 ILE B N 1 ATOM 1348 C CA . ILE A 1 239 ? -49.312 -29.603 29.931 1.00 41.73 ? 212 ILE B CA 1 ATOM 1349 C C . ILE A 1 239 ? -47.844 -29.264 29.882 1.00 43.31 ? 212 ILE B C 1 ATOM 1350 O O . ILE A 1 239 ? -47.412 -28.314 30.536 1.00 39.56 ? 212 ILE B O 1 ATOM 1351 C CB . ILE A 1 239 ? -50.091 -28.620 29.080 1.00 45.24 ? 212 ILE B CB 1 ATOM 1352 C CG1 . ILE A 1 239 ? -51.534 -29.091 28.965 1.00 50.47 ? 212 ILE B CG1 1 ATOM 1353 C CG2 . ILE A 1 239 ? -49.482 -28.511 27.691 1.00 46.99 ? 212 ILE B CG2 1 ATOM 1354 C CD1 . ILE A 1 239 ? -52.487 -27.955 28.694 1.00 56.43 ? 212 ILE B CD1 1 ATOM 1355 N N . ALA A 1 240 ? -47.064 -30.053 29.147 1.00 44.39 ? 213 ALA B N 1 ATOM 1356 C CA . ALA A 1 240 ? -45.633 -29.804 29.055 1.00 42.62 ? 213 ALA B CA 1 ATOM 1357 C C . ALA A 1 240 ? -45.142 -30.071 27.656 1.00 45.02 ? 213 ALA B C 1 ATOM 1358 O O . ALA A 1 240 ? -45.678 -30.948 26.991 1.00 48.82 ? 213 ALA B O 1 ATOM 1359 C CB . ALA A 1 240 ? -44.933 -30.691 30.016 1.00 42.29 ? 213 ALA B CB 1 ATOM 1360 N N . ALA A 1 241 ? -44.140 -29.310 27.208 1.00 45.83 ? 214 ALA B N 1 ATOM 1361 C CA . ALA A 1 241 ? -43.481 -29.557 25.911 1.00 45.31 ? 214 ALA B CA 1 ATOM 1362 C C . ALA A 1 241 ? -42.706 -30.856 25.910 1.00 43.72 ? 214 ALA B C 1 ATOM 1363 O O . ALA A 1 241 ? -41.997 -31.159 26.853 1.00 49.80 ? 214 ALA B O 1 ATOM 1364 C CB . ALA A 1 241 ? -42.559 -28.416 25.569 1.00 46.57 ? 214 ALA B CB 1 ATOM 1365 N N . ASP A 1 242 ? -42.860 -31.642 24.860 1.00 48.08 ? 215 ASP B N 1 ATOM 1366 C CA . ASP A 1 242 ? -42.222 -32.957 24.781 1.00 49.94 ? 215 ASP B CA 1 ATOM 1367 C C . ASP A 1 242 ? -40.747 -32.786 24.415 1.00 50.11 ? 215 ASP B C 1 ATOM 1368 O O . ASP A 1 242 ? -40.358 -32.981 23.279 1.00 55.94 ? 215 ASP B O 1 ATOM 1369 C CB . ASP A 1 242 ? -42.960 -33.845 23.769 1.00 49.11 ? 215 ASP B CB 1 ATOM 1370 C CG . ASP A 1 242 ? -42.606 -35.323 23.902 1.00 55.68 ? 215 ASP B CG 1 ATOM 1371 O OD1 . ASP A 1 242 ? -41.810 -35.642 24.811 1.00 61.34 ? 215 ASP B OD1 1 ATOM 1372 O OD2 . ASP A 1 242 ? -43.134 -36.174 23.121 1.00 53.15 ? 215 ASP B OD2 1 ATOM 1373 N N . ASP A 1 243 ? -39.934 -32.418 25.396 1.00 54.19 ? 216 ASP B N 1 ATOM 1374 C CA . ASP A 1 243 ? -38.491 -32.196 25.200 1.00 55.35 ? 216 ASP B CA 1 ATOM 1375 C C . ASP A 1 243 ? -37.779 -32.150 26.563 1.00 49.46 ? 216 ASP B C 1 ATOM 1376 O O . ASP A 1 243 ? -38.437 -32.336 27.589 1.00 49.93 ? 216 ASP B O 1 ATOM 1377 C CB . ASP A 1 243 ? -38.223 -30.926 24.376 1.00 54.45 ? 216 ASP B CB 1 ATOM 1378 C CG . ASP A 1 243 ? -38.775 -29.632 25.030 1.00 60.19 ? 216 ASP B CG 1 ATOM 1379 O OD1 . ASP A 1 243 ? -38.567 -29.359 26.247 1.00 54.43 ? 216 ASP B OD1 1 ATOM 1380 O OD2 . ASP A 1 243 ? -39.400 -28.857 24.273 1.00 68.97 ? 216 ASP B OD2 1 ATOM 1381 N N . ASP A 1 244 ? -36.463 -31.907 26.567 1.00 45.76 ? 217 ASP B N 1 ATOM 1382 C CA . ASP A 1 244 ? -35.675 -31.988 27.790 1.00 46.75 ? 217 ASP B CA 1 ATOM 1383 C C . ASP A 1 244 ? -35.870 -30.735 28.642 1.00 48.95 ? 217 ASP B C 1 ATOM 1384 O O . ASP A 1 244 ? -35.270 -30.661 29.715 1.00 54.79 ? 217 ASP B O 1 ATOM 1385 C CB . ASP A 1 244 ? -34.165 -32.129 27.533 1.00 55.23 ? 217 ASP B CB 1 ATOM 1386 C CG . ASP A 1 244 ? -33.744 -33.473 26.919 1.00 61.68 ? 217 ASP B CG 1 ATOM 1387 O OD1 . ASP A 1 244 ? -34.356 -34.521 27.255 1.00 65.49 ? 217 ASP B OD1 1 ATOM 1388 O OD2 . ASP A 1 244 ? -32.743 -33.455 26.130 1.00 60.25 ? 217 ASP B OD2 1 ATOM 1389 N N . TYR A 1 245 ? -36.653 -29.746 28.197 1.00 40.89 ? 218 TYR B N 1 ATOM 1390 C CA . TYR A 1 245 ? -37.114 -28.701 29.133 1.00 42.45 ? 218 TYR B CA 1 ATOM 1391 C C . TYR A 1 245 ? -38.452 -29.062 29.810 1.00 41.54 ? 218 TYR B C 1 ATOM 1392 O O . TYR A 1 245 ? -38.541 -29.096 31.028 1.00 47.89 ? 218 TYR B O 1 ATOM 1393 C CB . TYR A 1 245 ? -37.203 -27.352 28.441 1.00 38.55 ? 218 TYR B CB 1 ATOM 1394 C CG . TYR A 1 245 ? -37.919 -26.248 29.176 1.00 36.23 ? 218 TYR B CG 1 ATOM 1395 C CD1 . TYR A 1 245 ? -37.356 -25.653 30.272 1.00 35.44 ? 218 TYR B CD1 1 ATOM 1396 C CD2 . TYR A 1 245 ? -39.120 -25.719 28.684 1.00 39.98 ? 218 TYR B CD2 1 ATOM 1397 C CE1 . TYR A 1 245 ? -37.995 -24.629 30.945 1.00 39.01 ? 218 TYR B CE1 1 ATOM 1398 C CE2 . TYR A 1 245 ? -39.764 -24.662 29.320 1.00 41.56 ? 218 TYR B CE2 1 ATOM 1399 C CZ . TYR A 1 245 ? -39.198 -24.117 30.474 1.00 44.20 ? 218 TYR B CZ 1 ATOM 1400 O OH . TYR A 1 245 ? -39.811 -23.038 31.142 1.00 46.08 ? 218 TYR B OH 1 ATOM 1401 N N . GLY A 1 246 ? -39.469 -29.332 29.007 1.00 43.48 ? 219 GLY B N 1 ATOM 1402 C CA . GLY A 1 246 ? -40.812 -29.650 29.490 1.00 40.68 ? 219 GLY B CA 1 ATOM 1403 C C . GLY A 1 246 ? -40.887 -30.893 30.332 1.00 40.50 ? 219 GLY B C 1 ATOM 1404 O O . GLY A 1 246 ? -41.266 -30.794 31.494 1.00 45.64 ? 219 GLY B O 1 ATOM 1405 N N . ARG A 1 247 ? -40.485 -32.048 29.790 1.00 39.25 ? 220 ARG B N 1 ATOM 1406 C CA . ARG A 1 247 ? -40.598 -33.321 30.532 1.00 38.73 ? 220 ARG B CA 1 ATOM 1407 C C . ARG A 1 247 ? -39.981 -33.381 31.948 1.00 40.39 ? 220 ARG B C 1 ATOM 1408 O O . ARG A 1 247 ? -40.658 -33.764 32.899 1.00 41.96 ? 220 ARG B O 1 ATOM 1409 C CB . ARG A 1 247 ? -40.080 -34.490 29.710 1.00 39.24 ? 220 ARG B CB 1 ATOM 1410 C CG . ARG A 1 247 ? -40.901 -34.755 28.462 1.00 44.13 ? 220 ARG B CG 1 ATOM 1411 C CD . ARG A 1 247 ? -40.515 -36.052 27.765 1.00 44.00 ? 220 ARG B CD 1 ATOM 1412 N NE . ARG A 1 247 ? -39.083 -36.120 27.533 1.00 45.21 ? 220 ARG B NE 1 ATOM 1413 C CZ . ARG A 1 247 ? -38.459 -35.831 26.398 1.00 49.35 ? 220 ARG B CZ 1 ATOM 1414 N NH1 . ARG A 1 247 ? -39.112 -35.436 25.315 1.00 53.85 ? 220 ARG B NH1 1 ATOM 1415 N NH2 . ARG A 1 247 ? -37.144 -35.955 26.354 1.00 52.61 ? 220 ARG B NH2 1 ATOM 1416 N N . PRO A 1 248 ? -38.695 -33.056 32.092 1.00 44.65 ? 221 PRO B N 1 ATOM 1417 C CA . PRO A 1 248 ? -38.132 -33.091 33.455 1.00 43.05 ? 221 PRO B CA 1 ATOM 1418 C C . PRO A 1 248 ? -38.762 -32.034 34.401 1.00 44.91 ? 221 PRO B C 1 ATOM 1419 O O . PRO A 1 248 ? -38.937 -32.292 35.597 1.00 45.12 ? 221 PRO B O 1 ATOM 1420 C CB . PRO A 1 248 ? -36.637 -32.802 33.248 1.00 41.87 ? 221 PRO B CB 1 ATOM 1421 C CG . PRO A 1 248 ? -36.417 -32.642 31.780 1.00 45.37 ? 221 PRO B CG 1 ATOM 1422 C CD . PRO A 1 248 ? -37.755 -32.497 31.098 1.00 45.82 ? 221 PRO B CD 1 ATOM 1423 N N . GLY A 1 249 ? -39.111 -30.867 33.866 1.00 42.83 ? 222 GLY B N 1 ATOM 1424 C CA . GLY A 1 249 ? -39.775 -29.831 34.649 1.00 42.88 ? 222 GLY B CA 1 ATOM 1425 C C . GLY A 1 249 ? -41.106 -30.314 35.219 1.00 42.45 ? 222 GLY B C 1 ATOM 1426 O O . GLY A 1 249 ? -41.317 -30.225 36.400 1.00 40.15 ? 222 GLY B O 1 ATOM 1427 N N . ILE A 1 250 ? -42.009 -30.817 34.379 1.00 42.30 ? 223 ILE B N 1 ATOM 1428 C CA . ILE A 1 250 ? -43.304 -31.257 34.882 1.00 48.48 ? 223 ILE B CA 1 ATOM 1429 C C . ILE A 1 250 ? -43.237 -32.478 35.757 1.00 45.60 ? 223 ILE B C 1 ATOM 1430 O O . ILE A 1 250 ? -44.096 -32.627 36.578 1.00 47.13 ? 223 ILE B O 1 ATOM 1431 C CB . ILE A 1 250 ? -44.382 -31.497 33.774 1.00 49.77 ? 223 ILE B CB 1 ATOM 1432 C CG1 . ILE A 1 250 ? -45.758 -31.059 34.292 1.00 45.24 ? 223 ILE B CG1 1 ATOM 1433 C CG2 . ILE A 1 250 ? -44.424 -32.927 33.280 1.00 45.51 ? 223 ILE B CG2 1 ATOM 1434 C CD1 . ILE A 1 250 ? -45.874 -29.537 34.336 1.00 45.31 ? 223 ILE B CD1 1 ATOM 1435 N N . GLU A 1 251 ? -42.249 -33.348 35.557 1.00 46.39 ? 224 GLU B N 1 ATOM 1436 C CA . GLU A 1 251 ? -42.089 -34.518 36.397 1.00 46.84 ? 224 GLU B CA 1 ATOM 1437 C C . GLU A 1 251 ? -41.779 -34.063 37.801 1.00 46.04 ? 224 GLU B C 1 ATOM 1438 O O . GLU A 1 251 ? -42.322 -34.577 38.772 1.00 44.28 ? 224 GLU B O 1 ATOM 1439 C CB . GLU A 1 251 ? -40.971 -35.411 35.864 1.00 50.75 ? 224 GLU B CB 1 ATOM 1440 C CG . GLU A 1 251 ? -40.753 -36.731 36.613 1.00 55.65 ? 224 GLU B CG 1 ATOM 1441 C CD . GLU A 1 251 ? -42.021 -37.493 37.019 1.00 65.03 ? 224 GLU B CD 1 ATOM 1442 O OE1 . GLU A 1 251 ? -41.884 -38.302 37.960 1.00 73.11 ? 224 GLU B OE1 1 ATOM 1443 O OE2 . GLU A 1 251 ? -43.136 -37.326 36.427 1.00 70.00 ? 224 GLU B OE2 1 ATOM 1444 N N . LYS A 1 252 ? -40.928 -33.056 37.895 1.00 44.61 ? 225 LYS B N 1 ATOM 1445 C CA . LYS A 1 252 ? -40.590 -32.505 39.160 1.00 44.34 ? 225 LYS B CA 1 ATOM 1446 C C . LYS A 1 252 ? -41.807 -31.889 39.784 1.00 45.50 ? 225 LYS B C 1 ATOM 1447 O O . LYS A 1 252 ? -42.066 -32.105 40.965 1.00 44.77 ? 225 LYS B O 1 ATOM 1448 C CB . LYS A 1 252 ? -39.515 -31.451 38.995 1.00 48.67 ? 225 LYS B CB 1 ATOM 1449 C CG . LYS A 1 252 ? -39.100 -30.747 40.279 1.00 51.63 ? 225 LYS B CG 1 ATOM 1450 C CD . LYS A 1 252 ? -38.689 -31.701 41.375 1.00 47.65 ? 225 LYS B CD 1 ATOM 1451 C CE . LYS A 1 252 ? -38.085 -30.923 42.525 1.00 51.62 ? 225 LYS B CE 1 ATOM 1452 N NZ . LYS A 1 252 ? -37.756 -31.882 43.628 1.00 54.05 ? 225 LYS B NZ 1 ATOM 1453 N N . PHE A 1 253 ? -42.550 -31.114 39.001 1.00 45.09 ? 226 PHE B N 1 ATOM 1454 C CA . PHE A 1 253 ? -43.758 -30.499 39.513 1.00 45.43 ? 226 PHE B CA 1 ATOM 1455 C C . PHE A 1 253 ? -44.723 -31.541 40.079 1.00 45.99 ? 226 PHE B C 1 ATOM 1456 O O . PHE A 1 253 ? -45.297 -31.334 41.123 1.00 47.60 ? 226 PHE B O 1 ATOM 1457 C CB . PHE A 1 253 ? -44.483 -29.668 38.467 1.00 44.88 ? 226 PHE B CB 1 ATOM 1458 C CG . PHE A 1 253 ? -45.875 -29.263 38.910 1.00 47.80 ? 226 PHE B CG 1 ATOM 1459 C CD1 . PHE A 1 253 ? -46.042 -28.299 39.874 1.00 47.84 ? 226 PHE B CD1 1 ATOM 1460 C CD2 . PHE A 1 253 ? -46.987 -29.881 38.408 1.00 47.09 ? 226 PHE B CD2 1 ATOM 1461 C CE1 . PHE A 1 253 ? -47.284 -27.957 40.326 1.00 48.67 ? 226 PHE B CE1 1 ATOM 1462 C CE2 . PHE A 1 253 ? -48.234 -29.523 38.838 1.00 51.48 ? 226 PHE B CE2 1 ATOM 1463 C CZ . PHE A 1 253 ? -48.386 -28.565 39.807 1.00 50.25 ? 226 PHE B CZ 1 ATOM 1464 N N . ARG A 1 254 ? -44.864 -32.670 39.406 1.00 50.91 ? 227 ARG B N 1 ATOM 1465 C CA . ARG A 1 254 ? -45.757 -33.730 39.852 1.00 53.25 ? 227 ARG B CA 1 ATOM 1466 C C . ARG A 1 254 ? -45.359 -34.198 41.237 1.00 53.71 ? 227 ARG B C 1 ATOM 1467 O O . ARG A 1 254 ? -46.174 -34.193 42.154 1.00 52.21 ? 227 ARG B O 1 ATOM 1468 C CB . ARG A 1 254 ? -45.734 -34.895 38.876 1.00 52.82 ? 227 ARG B CB 1 ATOM 1469 C CG . ARG A 1 254 ? -46.831 -35.918 39.135 1.00 55.90 ? 227 ARG B CG 1 ATOM 1470 C CD . ARG A 1 254 ? -46.545 -37.275 38.480 1.00 58.83 ? 227 ARG B CD 1 ATOM 1471 N NE . ARG A 1 254 ? -45.182 -37.765 38.762 1.00 64.10 ? 227 ARG B NE 1 ATOM 1472 C CZ . ARG A 1 254 ? -44.741 -38.135 39.967 1.00 64.25 ? 227 ARG B CZ 1 ATOM 1473 N NH1 . ARG A 1 254 ? -45.533 -38.113 41.038 1.00 62.28 ? 227 ARG B NH1 1 ATOM 1474 N NH2 . ARG A 1 254 ? -43.488 -38.524 40.105 1.00 68.83 ? 227 ARG B NH2 1 ATOM 1475 N N . GLU A 1 255 ? -44.094 -34.565 41.394 1.00 55.99 ? 228 GLU B N 1 ATOM 1476 C CA . GLU A 1 255 ? -43.567 -34.970 42.697 1.00 57.80 ? 228 GLU B CA 1 ATOM 1477 C C . GLU A 1 255 ? -43.936 -33.968 43.802 1.00 54.44 ? 228 GLU B C 1 ATOM 1478 O O . GLU A 1 255 ? -44.421 -34.326 44.853 1.00 62.48 ? 228 GLU B O 1 ATOM 1479 C CB . GLU A 1 255 ? -42.053 -35.122 42.608 1.00 57.71 ? 228 GLU B CB 1 ATOM 1480 C CG . GLU A 1 255 ? -41.357 -35.469 43.907 1.00 61.30 ? 228 GLU B CG 1 ATOM 1481 C CD . GLU A 1 255 ? -39.863 -35.214 43.841 1.00 75.04 ? 228 GLU B CD 1 ATOM 1482 O OE1 . GLU A 1 255 ? -39.241 -35.537 42.788 1.00 73.42 ? 228 GLU B OE1 1 ATOM 1483 O OE2 . GLU A 1 255 ? -39.321 -34.674 44.845 1.00 82.64 ? 228 GLU B OE2 1 ATOM 1484 N N . GLU A 1 256 ? -43.713 -32.709 43.534 1.00 53.47 ? 229 GLU B N 1 ATOM 1485 C CA . GLU A 1 256 ? -43.934 -31.678 44.509 1.00 55.49 ? 229 GLU B CA 1 ATOM 1486 C C . GLU A 1 256 ? -45.399 -31.473 44.788 1.00 50.03 ? 229 GLU B C 1 ATOM 1487 O O . GLU A 1 256 ? -45.787 -31.091 45.881 1.00 46.94 ? 229 GLU B O 1 ATOM 1488 C CB . GLU A 1 256 ? -43.359 -30.363 43.984 1.00 59.22 ? 229 GLU B CB 1 ATOM 1489 C CG . GLU A 1 256 ? -41.858 -30.364 43.859 1.00 65.53 ? 229 GLU B CG 1 ATOM 1490 C CD . GLU A 1 256 ? -41.184 -30.669 45.167 1.00 73.37 ? 229 GLU B CD 1 ATOM 1491 O OE1 . GLU A 1 256 ? -41.569 -30.048 46.188 1.00 80.35 ? 229 GLU B OE1 1 ATOM 1492 O OE2 . GLU A 1 256 ? -40.277 -31.540 45.173 1.00 90.91 ? 229 GLU B OE2 1 ATOM 1493 N N . ALA A 1 257 ? -46.206 -31.649 43.760 1.00 49.16 ? 230 ALA B N 1 ATOM 1494 C CA . ALA A 1 257 ? -47.624 -31.500 43.910 1.00 49.62 ? 230 ALA B CA 1 ATOM 1495 C C . ALA A 1 257 ? -48.141 -32.604 44.832 1.00 55.83 ? 230 ALA B C 1 ATOM 1496 O O . ALA A 1 257 ? -48.899 -32.337 45.740 1.00 55.40 ? 230 ALA B O 1 ATOM 1497 C CB . ALA A 1 257 ? -48.283 -31.568 42.554 1.00 48.36 ? 230 ALA B CB 1 ATOM 1498 N N . GLU A 1 258 ? -47.711 -33.843 44.594 1.00 60.15 ? 231 GLU B N 1 ATOM 1499 C CA . GLU A 1 258 ? -48.082 -34.947 45.450 1.00 59.48 ? 231 GLU B CA 1 ATOM 1500 C C . GLU A 1 258 ? -47.740 -34.619 46.917 1.00 54.90 ? 231 GLU B C 1 ATOM 1501 O O . GLU A 1 258 ? -48.599 -34.782 47.779 1.00 57.02 ? 231 GLU B O 1 ATOM 1502 C CB . GLU A 1 258 ? -47.434 -36.268 44.981 1.00 60.13 ? 231 GLU B CB 1 ATOM 1503 N N . GLU A 1 259 ? -46.536 -34.124 47.205 1.00 53.65 ? 232 GLU B N 1 ATOM 1504 C CA . GLU A 1 259 ? -46.117 -33.872 48.608 1.00 60.27 ? 232 GLU B CA 1 ATOM 1505 C C . GLU A 1 259 ? -47.083 -32.944 49.303 1.00 60.34 ? 232 GLU B C 1 ATOM 1506 O O . GLU A 1 259 ? -47.229 -32.995 50.505 1.00 68.36 ? 232 GLU B O 1 ATOM 1507 C CB . GLU A 1 259 ? -44.701 -33.281 48.712 1.00 66.11 ? 232 GLU B CB 1 ATOM 1508 C CG . GLU A 1 259 ? -43.607 -34.344 48.676 1.00 84.14 ? 232 GLU B CG 1 ATOM 1509 C CD . GLU A 1 259 ? -42.198 -33.773 48.521 1.00 102.42 ? 232 GLU B CD 1 ATOM 1510 O OE1 . GLU A 1 259 ? -42.041 -32.529 48.570 1.00 114.65 ? 232 GLU B OE1 1 ATOM 1511 O OE2 . GLU A 1 259 ? -41.241 -34.573 48.357 1.00 108.82 ? 232 GLU B OE2 1 ATOM 1512 N N . ARG A 1 260 ? -47.753 -32.102 48.529 1.00 59.83 ? 233 ARG B N 1 ATOM 1513 C CA . ARG A 1 260 ? -48.653 -31.104 49.057 1.00 54.69 ? 233 ARG B CA 1 ATOM 1514 C C . ARG A 1 260 ? -50.120 -31.451 48.808 1.00 51.67 ? 233 ARG B C 1 ATOM 1515 O O . ARG A 1 260 ? -50.985 -30.594 48.915 1.00 53.03 ? 233 ARG B O 1 ATOM 1516 C CB . ARG A 1 260 ? -48.317 -29.761 48.407 1.00 53.38 ? 233 ARG B CB 1 ATOM 1517 C CG . ARG A 1 260 ? -46.990 -29.157 48.826 1.00 48.54 ? 233 ARG B CG 1 ATOM 1518 C CD . ARG A 1 260 ? -46.622 -28.110 47.787 1.00 52.07 ? 233 ARG B CD 1 ATOM 1519 N NE . ARG A 1 260 ? -45.288 -27.545 47.965 1.00 53.12 ? 233 ARG B NE 1 ATOM 1520 C CZ . ARG A 1 260 ? -44.141 -28.210 47.816 1.00 49.75 ? 233 ARG B CZ 1 ATOM 1521 N NH1 . ARG A 1 260 ? -44.097 -29.503 47.492 1.00 50.55 ? 233 ARG B NH1 1 ATOM 1522 N NH2 . ARG A 1 260 ? -43.012 -27.569 48.009 1.00 48.97 ? 233 ARG B NH2 1 ATOM 1523 N N . ASP A 1 261 ? -50.403 -32.701 48.485 1.00 54.71 ? 234 ASP B N 1 ATOM 1524 C CA . ASP A 1 261 ? -51.778 -33.155 48.208 1.00 65.07 ? 234 ASP B CA 1 ATOM 1525 C C . ASP A 1 261 ? -52.562 -32.248 47.257 1.00 63.03 ? 234 ASP B C 1 ATOM 1526 O O . ASP A 1 261 ? -53.694 -31.870 47.496 1.00 57.80 ? 234 ASP B O 1 ATOM 1527 C CB . ASP A 1 261 ? -52.529 -33.451 49.504 1.00 68.72 ? 234 ASP B CB 1 ATOM 1528 C CG . ASP A 1 261 ? -52.258 -34.850 49.988 1.00 82.49 ? 234 ASP B CG 1 ATOM 1529 O OD1 . ASP A 1 261 ? -52.578 -35.810 49.223 1.00 91.47 ? 234 ASP B OD1 1 ATOM 1530 O OD2 . ASP A 1 261 ? -51.690 -34.984 51.101 1.00 83.21 ? 234 ASP B OD2 1 ATOM 1531 N N . ILE A 1 262 ? -51.905 -31.947 46.149 1.00 62.96 ? 235 ILE B N 1 ATOM 1532 C CA . ILE A 1 262 ? -52.474 -31.252 45.030 1.00 58.02 ? 235 ILE B CA 1 ATOM 1533 C C . ILE A 1 262 ? -52.777 -32.350 44.010 1.00 54.97 ? 235 ILE B C 1 ATOM 1534 O O . ILE A 1 262 ? -51.898 -33.106 43.657 1.00 62.91 ? 235 ILE B O 1 ATOM 1535 C CB . ILE A 1 262 ? -51.448 -30.217 44.502 1.00 56.64 ? 235 ILE B CB 1 ATOM 1536 C CG1 . ILE A 1 262 ? -51.460 -28.970 45.388 1.00 56.02 ? 235 ILE B CG1 1 ATOM 1537 C CG2 . ILE A 1 262 ? -51.730 -29.823 43.062 1.00 57.96 ? 235 ILE B CG2 1 ATOM 1538 C CD1 . ILE A 1 262 ? -50.180 -28.164 45.321 1.00 57.20 ? 235 ILE B CD1 1 HETATM 1539 N N . CSO A 1 263 ? -54.012 -32.441 43.537 1.00 53.92 ? 236 CSO B N 1 HETATM 1540 C CA . CSO A 1 263 ? -54.395 -33.494 42.592 1.00 57.06 ? 236 CSO B CA 1 HETATM 1541 C CB . CSO A 1 263 ? -55.791 -34.088 42.862 1.00 63.02 ? 236 CSO B CB 1 HETATM 1542 S SG . CSO A 1 263 ? -55.809 -34.752 44.517 1.00 78.78 ? 236 CSO B SG 1 HETATM 1543 C C . CSO A 1 263 ? -54.354 -32.997 41.197 1.00 53.01 ? 236 CSO B C 1 HETATM 1544 O O . CSO A 1 263 ? -54.772 -31.883 40.909 1.00 61.56 ? 236 CSO B O 1 HETATM 1545 O OD . CSO A 1 263 ? -55.260 -36.406 44.383 1.00 78.99 ? 236 CSO B OD 1 ATOM 1546 N N . ILE A 1 264 ? -53.847 -33.847 40.314 1.00 50.44 ? 237 ILE B N 1 ATOM 1547 C CA . ILE A 1 264 ? -53.688 -33.549 38.912 1.00 44.16 ? 237 ILE B CA 1 ATOM 1548 C C . ILE A 1 264 ? -54.666 -34.401 38.111 1.00 43.88 ? 237 ILE B C 1 ATOM 1549 O O . ILE A 1 264 ? -54.614 -35.623 38.107 1.00 43.63 ? 237 ILE B O 1 ATOM 1550 C CB . ILE A 1 264 ? -52.236 -33.848 38.497 1.00 46.38 ? 237 ILE B CB 1 ATOM 1551 C CG1 . ILE A 1 264 ? -51.285 -33.081 39.436 1.00 49.22 ? 237 ILE B CG1 1 ATOM 1552 C CG2 . ILE A 1 264 ? -51.997 -33.540 37.020 1.00 42.79 ? 237 ILE B CG2 1 ATOM 1553 C CD1 . ILE A 1 264 ? -49.817 -33.215 39.100 1.00 51.08 ? 237 ILE B CD1 1 ATOM 1554 N N . ASP A 1 265 ? -55.577 -33.739 37.434 1.00 48.60 ? 238 ASP B N 1 ATOM 1555 C CA . ASP A 1 265 ? -56.634 -34.415 36.723 1.00 50.04 ? 238 ASP B CA 1 ATOM 1556 C C . ASP A 1 265 ? -56.228 -34.821 35.326 1.00 48.52 ? 238 ASP B C 1 ATOM 1557 O O . ASP A 1 265 ? -56.822 -35.729 34.756 1.00 48.19 ? 238 ASP B O 1 ATOM 1558 C CB . ASP A 1 265 ? -57.869 -33.506 36.618 1.00 49.53 ? 238 ASP B CB 1 ATOM 1559 C CG . ASP A 1 265 ? -59.062 -34.231 35.978 1.00 51.87 ? 238 ASP B CG 1 ATOM 1560 O OD1 . ASP A 1 265 ? -59.458 -35.338 36.468 1.00 50.13 ? 238 ASP B OD1 1 ATOM 1561 O OD2 . ASP A 1 265 ? -59.566 -33.709 34.961 1.00 50.51 ? 238 ASP B OD2 1 ATOM 1562 N N . PHE A 1 266 ? -55.309 -34.080 34.727 1.00 49.15 ? 239 PHE B N 1 ATOM 1563 C CA . PHE A 1 266 ? -54.751 -34.511 33.451 1.00 49.87 ? 239 PHE B CA 1 ATOM 1564 C C . PHE A 1 266 ? -53.349 -34.024 33.299 1.00 52.57 ? 239 PHE B C 1 ATOM 1565 O O . PHE A 1 266 ? -52.929 -33.073 33.963 1.00 56.25 ? 239 PHE B O 1 ATOM 1566 C CB . PHE A 1 266 ? -55.579 -34.061 32.235 1.00 50.06 ? 239 PHE B CB 1 ATOM 1567 C CG . PHE A 1 266 ? -55.648 -32.579 32.047 1.00 45.93 ? 239 PHE B CG 1 ATOM 1568 C CD1 . PHE A 1 266 ? -54.603 -31.899 31.480 1.00 46.99 ? 239 PHE B CD1 1 ATOM 1569 C CD2 . PHE A 1 266 ? -56.759 -31.863 32.454 1.00 48.17 ? 239 PHE B CD2 1 ATOM 1570 C CE1 . PHE A 1 266 ? -54.639 -30.511 31.301 1.00 49.01 ? 239 PHE B CE1 1 ATOM 1571 C CE2 . PHE A 1 266 ? -56.806 -30.479 32.292 1.00 52.30 ? 239 PHE B CE2 1 ATOM 1572 C CZ . PHE A 1 266 ? -55.741 -29.796 31.697 1.00 48.20 ? 239 PHE B CZ 1 ATOM 1573 N N . SER A 1 267 ? -52.643 -34.699 32.399 1.00 55.74 ? 240 SER B N 1 ATOM 1574 C CA . SER A 1 267 ? -51.271 -34.391 32.082 1.00 53.37 ? 240 SER B CA 1 ATOM 1575 C C . SER A 1 267 ? -51.003 -34.751 30.621 1.00 49.79 ? 240 SER B C 1 ATOM 1576 O O . SER A 1 267 ? -51.139 -35.899 30.262 1.00 55.13 ? 240 SER B O 1 ATOM 1577 C CB . SER A 1 267 ? -50.377 -35.183 33.021 1.00 50.57 ? 240 SER B CB 1 ATOM 1578 O OG . SER A 1 267 ? -50.246 -36.530 32.591 1.00 52.39 ? 240 SER B OG 1 ATOM 1579 N N . GLU A 1 268 ? -50.647 -33.772 29.790 1.00 51.92 ? 241 GLU B N 1 ATOM 1580 C CA . GLU A 1 268 ? -50.469 -33.980 28.346 1.00 50.07 ? 241 GLU B CA 1 ATOM 1581 C C . GLU A 1 268 ? -49.216 -33.313 27.881 1.00 47.02 ? 241 GLU B C 1 ATOM 1582 O O . GLU A 1 268 ? -48.794 -32.353 28.476 1.00 51.23 ? 241 GLU B O 1 ATOM 1583 C CB . GLU A 1 268 ? -51.660 -33.398 27.537 1.00 57.79 ? 241 GLU B CB 1 ATOM 1584 C CG . GLU A 1 268 ? -53.069 -33.935 27.893 1.00 57.29 ? 241 GLU B CG 1 ATOM 1585 C CD . GLU A 1 268 ? -53.227 -35.456 27.731 1.00 60.56 ? 241 GLU B CD 1 ATOM 1586 O OE1 . GLU A 1 268 ? -53.737 -36.135 28.674 1.00 67.39 ? 241 GLU B OE1 1 ATOM 1587 O OE2 . GLU A 1 268 ? -52.836 -35.982 26.666 1.00 61.66 ? 241 GLU B OE2 1 ATOM 1588 N N . LEU A 1 269 ? -48.631 -33.835 26.802 1.00 56.94 ? 242 LEU B N 1 ATOM 1589 C CA . LEU A 1 269 ? -47.425 -33.285 26.144 1.00 50.80 ? 242 LEU B CA 1 ATOM 1590 C C . LEU A 1 269 ? -47.777 -32.638 24.845 1.00 47.02 ? 242 LEU B C 1 ATOM 1591 O O . LEU A 1 269 ? -48.641 -33.110 24.153 1.00 45.86 ? 242 LEU B O 1 ATOM 1592 C CB . LEU A 1 269 ? -46.428 -34.400 25.832 1.00 52.25 ? 242 LEU B CB 1 ATOM 1593 C CG . LEU A 1 269 ? -46.059 -35.263 27.035 1.00 55.67 ? 242 LEU B CG 1 ATOM 1594 C CD1 . LEU A 1 269 ? -44.977 -36.239 26.612 1.00 58.60 ? 242 LEU B CD1 1 ATOM 1595 C CD2 . LEU A 1 269 ? -45.597 -34.407 28.206 1.00 56.86 ? 242 LEU B CD2 1 ATOM 1596 N N . ILE A 1 270 ? -47.086 -31.568 24.493 1.00 51.90 ? 243 ILE B N 1 ATOM 1597 C CA . ILE A 1 270 ? -47.269 -30.932 23.175 1.00 55.81 ? 243 ILE B CA 1 ATOM 1598 C C . ILE A 1 270 ? -45.937 -30.605 22.568 1.00 56.62 ? 243 ILE B C 1 ATOM 1599 O O . ILE A 1 270 ? -44.893 -30.839 23.198 1.00 52.61 ? 243 ILE B O 1 ATOM 1600 C CB . ILE A 1 270 ? -48.024 -29.606 23.269 1.00 58.23 ? 243 ILE B CB 1 ATOM 1601 C CG1 . ILE A 1 270 ? -47.184 -28.600 24.059 1.00 58.21 ? 243 ILE B CG1 1 ATOM 1602 C CG2 . ILE A 1 270 ? -49.386 -29.852 23.898 1.00 59.66 ? 243 ILE B CG2 1 ATOM 1603 C CD1 . ILE A 1 270 ? -47.931 -27.353 24.454 1.00 62.18 ? 243 ILE B CD1 1 ATOM 1604 N N . SER A 1 271 ? -45.984 -30.043 21.358 1.00 53.21 ? 244 SER B N 1 ATOM 1605 C CA . SER A 1 271 ? -44.783 -29.630 20.658 1.00 52.58 ? 244 SER B CA 1 ATOM 1606 C C . SER A 1 271 ? -45.086 -28.687 19.511 1.00 51.61 ? 244 SER B C 1 ATOM 1607 O O . SER A 1 271 ? -46.185 -28.675 18.965 1.00 51.83 ? 244 SER B O 1 ATOM 1608 C CB . SER A 1 271 ? -44.061 -30.872 20.123 1.00 55.90 ? 244 SER B CB 1 ATOM 1609 O OG . SER A 1 271 ? -43.524 -30.642 18.837 1.00 66.50 ? 244 SER B OG 1 ATOM 1610 N N . GLN A 1 272 ? -44.080 -27.927 19.118 1.00 52.61 ? 245 GLN B N 1 ATOM 1611 C CA . GLN A 1 272 ? -44.138 -27.142 17.896 1.00 57.01 ? 245 GLN B CA 1 ATOM 1612 C C . GLN A 1 272 ? -44.672 -27.935 16.698 1.00 54.78 ? 245 GLN B C 1 ATOM 1613 O O . GLN A 1 272 ? -45.451 -27.389 15.935 1.00 54.47 ? 245 GLN B O 1 ATOM 1614 C CB . GLN A 1 272 ? -42.751 -26.588 17.589 1.00 62.34 ? 245 GLN B CB 1 ATOM 1615 C CG . GLN A 1 272 ? -42.676 -25.662 16.401 1.00 70.01 ? 245 GLN B CG 1 ATOM 1616 C CD . GLN A 1 272 ? -41.347 -24.945 16.333 1.00 76.47 ? 245 GLN B CD 1 ATOM 1617 O OE1 . GLN A 1 272 ? -40.451 -25.222 17.121 1.00 88.63 ? 245 GLN B OE1 1 ATOM 1618 N NE2 . GLN A 1 272 ? -41.216 -24.013 15.400 1.00 78.64 ? 245 GLN B NE2 1 ATOM 1619 N N . TYR A 1 273 ? -44.293 -29.211 16.566 1.00 56.49 ? 246 TYR B N 1 ATOM 1620 C CA . TYR A 1 273 ? -44.672 -30.060 15.404 1.00 61.47 ? 246 TYR B CA 1 ATOM 1621 C C . TYR A 1 273 ? -45.776 -31.063 15.644 1.00 63.36 ? 246 TYR B C 1 ATOM 1622 O O . TYR A 1 273 ? -45.902 -32.001 14.870 1.00 75.86 ? 246 TYR B O 1 ATOM 1623 C CB . TYR A 1 273 ? -43.435 -30.808 14.851 1.00 62.85 ? 246 TYR B CB 1 ATOM 1624 C CG . TYR A 1 273 ? -42.387 -29.798 14.519 1.00 72.84 ? 246 TYR B CG 1 ATOM 1625 C CD1 . TYR A 1 273 ? -42.533 -28.974 13.410 1.00 72.23 ? 246 TYR B CD1 1 ATOM 1626 C CD2 . TYR A 1 273 ? -41.312 -29.574 15.374 1.00 74.67 ? 246 TYR B CD2 1 ATOM 1627 C CE1 . TYR A 1 273 ? -41.601 -27.994 13.122 1.00 78.89 ? 246 TYR B CE1 1 ATOM 1628 C CE2 . TYR A 1 273 ? -40.383 -28.591 15.097 1.00 78.20 ? 246 TYR B CE2 1 ATOM 1629 C CZ . TYR A 1 273 ? -40.532 -27.804 13.973 1.00 75.62 ? 246 TYR B CZ 1 ATOM 1630 O OH . TYR A 1 273 ? -39.619 -26.812 13.704 1.00 80.42 ? 246 TYR B OH 1 ATOM 1631 N N . SER A 1 274 ? -46.587 -30.894 16.685 1.00 64.50 ? 247 SER B N 1 ATOM 1632 C CA . SER A 1 274 ? -47.759 -31.778 16.877 1.00 62.21 ? 247 SER B CA 1 ATOM 1633 C C . SER A 1 274 ? -48.739 -31.628 15.723 1.00 61.30 ? 247 SER B C 1 ATOM 1634 O O . SER A 1 274 ? -48.991 -30.516 15.272 1.00 58.86 ? 247 SER B O 1 ATOM 1635 C CB . SER A 1 274 ? -48.503 -31.468 18.182 1.00 58.50 ? 247 SER B CB 1 ATOM 1636 O OG . SER A 1 274 ? -47.614 -31.031 19.180 1.00 61.17 ? 247 SER B OG 1 ATOM 1637 N N . ASP A 1 275 ? -49.310 -32.735 15.260 1.00 67.42 ? 248 ASP B N 1 ATOM 1638 C CA . ASP A 1 275 ? -50.323 -32.673 14.192 1.00 71.45 ? 248 ASP B CA 1 ATOM 1639 C C . ASP A 1 275 ? -51.713 -32.281 14.730 1.00 70.79 ? 248 ASP B C 1 ATOM 1640 O O . ASP A 1 275 ? -51.948 -32.253 15.933 1.00 79.67 ? 248 ASP B O 1 ATOM 1641 C CB . ASP A 1 275 ? -50.368 -33.979 13.382 1.00 77.11 ? 248 ASP B CB 1 ATOM 1642 C CG . ASP A 1 275 ? -50.663 -35.220 14.229 1.00 85.75 ? 248 ASP B CG 1 ATOM 1643 O OD1 . ASP A 1 275 ? -51.463 -35.145 15.187 1.00 90.34 ? 248 ASP B OD1 1 ATOM 1644 O OD2 . ASP A 1 275 ? -50.099 -36.293 13.904 1.00 100.36 ? 248 ASP B OD2 1 ATOM 1645 N N . GLU A 1 276 ? -52.632 -31.976 13.831 1.00 70.45 ? 249 GLU B N 1 ATOM 1646 C CA . GLU A 1 276 ? -53.955 -31.508 14.216 1.00 65.92 ? 249 GLU B CA 1 ATOM 1647 C C . GLU A 1 276 ? -54.664 -32.523 15.135 1.00 62.94 ? 249 GLU B C 1 ATOM 1648 O O . GLU A 1 276 ? -55.338 -32.135 16.082 1.00 69.15 ? 249 GLU B O 1 ATOM 1649 C CB . GLU A 1 276 ? -54.789 -31.159 12.952 1.00 58.32 ? 249 GLU B CB 1 ATOM 1650 N N . GLU A 1 277 ? -54.500 -33.813 14.879 1.00 63.73 ? 250 GLU B N 1 ATOM 1651 C CA . GLU A 1 277 ? -55.203 -34.837 15.672 1.00 69.65 ? 250 GLU B CA 1 ATOM 1652 C C . GLU A 1 277 ? -54.699 -34.816 17.117 1.00 71.35 ? 250 GLU B C 1 ATOM 1653 O O . GLU A 1 277 ? -55.488 -34.903 18.058 1.00 70.63 ? 250 GLU B O 1 ATOM 1654 C CB . GLU A 1 277 ? -55.045 -36.247 15.051 1.00 67.03 ? 250 GLU B CB 1 ATOM 1655 N N . GLU A 1 278 ? -53.378 -34.697 17.274 1.00 72.38 ? 251 GLU B N 1 ATOM 1656 C CA . GLU A 1 278 ? -52.734 -34.584 18.585 1.00 65.25 ? 251 GLU B CA 1 ATOM 1657 C C . GLU A 1 278 ? -53.192 -33.329 19.323 1.00 61.94 ? 251 GLU B C 1 ATOM 1658 O O . GLU A 1 278 ? -53.436 -33.393 20.526 1.00 56.72 ? 251 GLU B O 1 ATOM 1659 C CB . GLU A 1 278 ? -51.207 -34.569 18.452 1.00 68.24 ? 251 GLU B CB 1 ATOM 1660 C CG . GLU A 1 278 ? -50.575 -35.906 18.062 1.00 78.94 ? 251 GLU B CG 1 ATOM 1661 C CD . GLU A 1 278 ? -49.145 -35.793 17.499 1.00 85.54 ? 251 GLU B CD 1 ATOM 1662 O OE1 . GLU A 1 278 ? -48.785 -34.754 16.898 1.00 82.17 ? 251 GLU B OE1 1 ATOM 1663 O OE2 . GLU A 1 278 ? -48.368 -36.764 17.640 1.00 89.67 ? 251 GLU B OE2 1 ATOM 1664 N N . ILE A 1 279 ? -53.307 -32.196 18.621 1.00 60.05 ? 252 ILE B N 1 ATOM 1665 C CA . ILE A 1 279 ? -53.819 -30.962 19.252 1.00 62.26 ? 252 ILE B CA 1 ATOM 1666 C C . ILE A 1 279 ? -55.292 -31.155 19.674 1.00 68.83 ? 252 ILE B C 1 ATOM 1667 O O . ILE A 1 279 ? -55.661 -30.899 20.839 1.00 68.67 ? 252 ILE B O 1 ATOM 1668 C CB . ILE A 1 279 ? -53.715 -29.717 18.338 1.00 58.39 ? 252 ILE B CB 1 ATOM 1669 C CG1 . ILE A 1 279 ? -52.292 -29.450 17.922 1.00 60.19 ? 252 ILE B CG1 1 ATOM 1670 C CG2 . ILE A 1 279 ? -54.252 -28.479 19.033 1.00 57.87 ? 252 ILE B CG2 1 ATOM 1671 C CD1 . ILE A 1 279 ? -51.344 -29.333 19.089 1.00 69.57 ? 252 ILE B CD1 1 ATOM 1672 N N . GLN A 1 280 ? -56.117 -31.635 18.741 1.00 65.14 ? 253 GLN B N 1 ATOM 1673 C CA . GLN A 1 280 ? -57.530 -31.827 19.027 1.00 67.06 ? 253 GLN B CA 1 ATOM 1674 C C . GLN A 1 280 ? -57.663 -32.612 20.328 1.00 61.96 ? 253 GLN B C 1 ATOM 1675 O O . GLN A 1 280 ? -58.462 -32.268 21.188 1.00 67.45 ? 253 GLN B O 1 ATOM 1676 C CB . GLN A 1 280 ? -58.267 -32.531 17.871 1.00 63.05 ? 253 GLN B CB 1 ATOM 1677 N N . HIS A 1 281 ? -56.853 -33.647 20.479 1.00 61.47 ? 254 HIS B N 1 ATOM 1678 C CA . HIS A 1 281 ? -56.942 -34.510 21.641 1.00 59.37 ? 254 HIS B CA 1 ATOM 1679 C C . HIS A 1 281 ? -56.658 -33.739 22.930 1.00 60.59 ? 254 HIS B C 1 ATOM 1680 O O . HIS A 1 281 ? -57.334 -33.953 23.940 1.00 57.58 ? 254 HIS B O 1 ATOM 1681 C CB . HIS A 1 281 ? -55.977 -35.685 21.507 1.00 59.83 ? 254 HIS B CB 1 ATOM 1682 C CG . HIS A 1 281 ? -56.038 -36.626 22.661 1.00 68.76 ? 254 HIS B CG 1 ATOM 1683 N ND1 . HIS A 1 281 ? -55.024 -36.733 23.588 1.00 76.81 ? 254 HIS B ND1 1 ATOM 1684 C CD2 . HIS A 1 281 ? -57.017 -37.462 23.079 1.00 76.27 ? 254 HIS B CD2 1 ATOM 1685 C CE1 . HIS A 1 281 ? -55.358 -37.619 24.509 1.00 73.10 ? 254 HIS B CE1 1 ATOM 1686 N NE2 . HIS A 1 281 ? -56.568 -38.069 24.228 1.00 78.19 ? 254 HIS B NE2 1 ATOM 1687 N N . VAL A 1 282 ? -55.677 -32.832 22.899 1.00 55.34 ? 255 VAL B N 1 ATOM 1688 C CA . VAL A 1 282 ? -55.279 -32.150 24.122 1.00 57.53 ? 255 VAL B CA 1 ATOM 1689 C C . VAL A 1 282 ? -56.375 -31.189 24.542 1.00 56.95 ? 255 VAL B C 1 ATOM 1690 O O . VAL A 1 282 ? -56.799 -31.170 25.701 1.00 54.38 ? 255 VAL B O 1 ATOM 1691 C CB . VAL A 1 282 ? -53.950 -31.400 23.959 1.00 55.80 ? 255 VAL B CB 1 ATOM 1692 C CG1 . VAL A 1 282 ? -53.656 -30.559 25.176 1.00 58.26 ? 255 VAL B CG1 1 ATOM 1693 C CG2 . VAL A 1 282 ? -52.830 -32.381 23.801 1.00 55.20 ? 255 VAL B CG2 1 ATOM 1694 N N . VAL A 1 283 ? -56.842 -30.424 23.564 1.00 57.45 ? 256 VAL B N 1 ATOM 1695 C CA . VAL A 1 283 ? -57.967 -29.528 23.742 1.00 56.11 ? 256 VAL B CA 1 ATOM 1696 C C . VAL A 1 283 ? -59.205 -30.269 24.230 1.00 58.91 ? 256 VAL B C 1 ATOM 1697 O O . VAL A 1 283 ? -59.988 -29.712 24.982 1.00 58.05 ? 256 VAL B O 1 ATOM 1698 C CB . VAL A 1 283 ? -58.339 -28.823 22.444 1.00 57.35 ? 256 VAL B CB 1 ATOM 1699 C CG1 . VAL A 1 283 ? -59.349 -27.738 22.730 1.00 62.74 ? 256 VAL B CG1 1 ATOM 1700 C CG2 . VAL A 1 283 ? -57.130 -28.179 21.804 1.00 63.90 ? 256 VAL B CG2 1 ATOM 1701 N N . GLU A 1 284 ? -59.400 -31.517 23.808 1.00 63.66 ? 257 GLU B N 1 ATOM 1702 C CA . GLU A 1 284 ? -60.559 -32.296 24.282 1.00 72.81 ? 257 GLU B CA 1 ATOM 1703 C C . GLU A 1 284 ? -60.419 -32.633 25.761 1.00 72.39 ? 257 GLU B C 1 ATOM 1704 O O . GLU A 1 284 ? -61.329 -32.365 26.567 1.00 67.57 ? 257 GLU B O 1 ATOM 1705 C CB . GLU A 1 284 ? -60.772 -33.575 23.465 1.00 76.32 ? 257 GLU B CB 1 ATOM 1706 C CG . GLU A 1 284 ? -61.530 -33.331 22.172 1.00 83.72 ? 257 GLU B CG 1 ATOM 1707 C CD . GLU A 1 284 ? -61.676 -34.581 21.333 1.00 91.85 ? 257 GLU B CD 1 ATOM 1708 O OE1 . GLU A 1 284 ? -62.273 -35.558 21.846 1.00 103.82 ? 257 GLU B OE1 1 ATOM 1709 O OE2 . GLU A 1 284 ? -61.200 -34.575 20.168 1.00 85.08 ? 257 GLU B OE2 1 ATOM 1710 N N . VAL A 1 285 ? -59.266 -33.193 26.110 1.00 65.10 ? 258 VAL B N 1 ATOM 1711 C CA . VAL A 1 285 ? -58.950 -33.457 27.501 1.00 61.58 ? 258 VAL B CA 1 ATOM 1712 C C . VAL A 1 285 ? -59.208 -32.206 28.352 1.00 59.94 ? 258 VAL B C 1 ATOM 1713 O O . VAL A 1 285 ? -59.816 -32.286 29.416 1.00 56.11 ? 258 VAL B O 1 ATOM 1714 C CB . VAL A 1 285 ? -57.491 -33.898 27.663 1.00 61.90 ? 258 VAL B CB 1 ATOM 1715 C CG1 . VAL A 1 285 ? -57.114 -33.942 29.135 1.00 67.52 ? 258 VAL B CG1 1 ATOM 1716 C CG2 . VAL A 1 285 ? -57.262 -35.264 27.037 1.00 61.61 ? 258 VAL B CG2 1 ATOM 1717 N N . ILE A 1 286 ? -58.763 -31.055 27.863 1.00 55.32 ? 259 ILE B N 1 ATOM 1718 C CA . ILE A 1 286 ? -58.978 -29.814 28.571 1.00 57.91 ? 259 ILE B CA 1 ATOM 1719 C C . ILE A 1 286 ? -60.485 -29.519 28.690 1.00 57.84 ? 259 ILE B C 1 ATOM 1720 O O . ILE A 1 286 ? -61.011 -29.361 29.783 1.00 56.33 ? 259 ILE B O 1 ATOM 1721 C CB . ILE A 1 286 ? -58.229 -28.646 27.876 1.00 61.77 ? 259 ILE B CB 1 ATOM 1722 C CG1 . ILE A 1 286 ? -56.718 -28.825 27.979 1.00 60.52 ? 259 ILE B CG1 1 ATOM 1723 C CG2 . ILE A 1 286 ? -58.583 -27.303 28.511 1.00 63.74 ? 259 ILE B CG2 1 ATOM 1724 C CD1 . ILE A 1 286 ? -55.924 -27.840 27.149 1.00 59.97 ? 259 ILE B CD1 1 ATOM 1725 N N . GLN A 1 287 ? -61.171 -29.448 27.554 1.00 62.21 ? 260 GLN B N 1 ATOM 1726 C CA . GLN A 1 287 ? -62.617 -29.208 27.525 1.00 61.10 ? 260 GLN B CA 1 ATOM 1727 C C . GLN A 1 287 ? -63.348 -30.158 28.462 1.00 60.23 ? 260 GLN B C 1 ATOM 1728 O O . GLN A 1 287 ? -64.286 -29.765 29.122 1.00 57.51 ? 260 GLN B O 1 ATOM 1729 C CB . GLN A 1 287 ? -63.172 -29.396 26.109 1.00 65.37 ? 260 GLN B CB 1 ATOM 1730 C CG . GLN A 1 287 ? -63.098 -28.168 25.211 1.00 69.08 ? 260 GLN B CG 1 ATOM 1731 C CD . GLN A 1 287 ? -63.600 -28.433 23.782 1.00 75.57 ? 260 GLN B CD 1 ATOM 1732 O OE1 . GLN A 1 287 ? -63.302 -29.475 23.174 1.00 77.69 ? 260 GLN B OE1 1 ATOM 1733 N NE2 . GLN A 1 287 ? -64.345 -27.476 23.230 1.00 77.03 ? 260 GLN B NE2 1 ATOM 1734 N N . ASN A 1 288 ? -62.904 -31.411 28.520 1.00 60.49 ? 261 ASN B N 1 ATOM 1735 C CA . ASN A 1 288 ? -63.588 -32.432 29.292 1.00 59.98 ? 261 ASN B CA 1 ATOM 1736 C C . ASN A 1 288 ? -63.268 -32.446 30.782 1.00 60.89 ? 261 ASN B C 1 ATOM 1737 O O . ASN A 1 288 ? -63.732 -33.338 31.487 1.00 60.21 ? 261 ASN B O 1 ATOM 1738 C CB . ASN A 1 288 ? -63.279 -33.812 28.703 1.00 65.30 ? 261 ASN B CB 1 ATOM 1739 C CG . ASN A 1 288 ? -63.943 -34.033 27.355 1.00 75.73 ? 261 ASN B CG 1 ATOM 1740 O OD1 . ASN A 1 288 ? -64.475 -33.095 26.732 1.00 78.38 ? 261 ASN B OD1 1 ATOM 1741 N ND2 . ASN A 1 288 ? -63.911 -35.283 26.889 1.00 83.92 ? 261 ASN B ND2 1 ATOM 1742 N N . SER A 1 289 ? -62.496 -31.474 31.274 1.00 61.18 ? 262 SER B N 1 ATOM 1743 C CA . SER A 1 289 ? -62.030 -31.492 32.661 1.00 58.20 ? 262 SER B CA 1 ATOM 1744 C C . SER A 1 289 ? -62.564 -30.335 33.487 1.00 60.42 ? 262 SER B C 1 ATOM 1745 O O . SER A 1 289 ? -62.621 -29.193 33.021 1.00 60.18 ? 262 SER B O 1 ATOM 1746 C CB . SER A 1 289 ? -60.506 -31.466 32.706 1.00 61.00 ? 262 SER B CB 1 ATOM 1747 O OG . SER A 1 289 ? -60.021 -31.320 34.040 1.00 60.97 ? 262 SER B OG 1 ATOM 1748 N N . THR A 1 290 ? -62.922 -30.625 34.737 1.00 66.86 ? 263 THR B N 1 ATOM 1749 C CA . THR A 1 290 ? -63.386 -29.574 35.649 1.00 73.19 ? 263 THR B CA 1 ATOM 1750 C C . THR A 1 290 ? -62.271 -28.616 36.088 1.00 71.43 ? 263 THR B C 1 ATOM 1751 O O . THR A 1 290 ? -62.556 -27.586 36.673 1.00 83.44 ? 263 THR B O 1 ATOM 1752 C CB . THR A 1 290 ? -64.082 -30.153 36.905 1.00 77.77 ? 263 THR B CB 1 ATOM 1753 O OG1 . THR A 1 290 ? -63.286 -31.197 37.477 1.00 89.04 ? 263 THR B OG1 1 ATOM 1754 C CG2 . THR A 1 290 ? -65.426 -30.713 36.538 1.00 82.16 ? 263 THR B CG2 1 ATOM 1755 N N . ALA A 1 291 ? -61.014 -28.953 35.806 1.00 71.14 ? 264 ALA B N 1 ATOM 1756 C CA . ALA A 1 291 ? -59.868 -28.142 36.227 1.00 61.88 ? 264 ALA B CA 1 ATOM 1757 C C . ALA A 1 291 ? -59.889 -26.776 35.597 1.00 52.07 ? 264 ALA B C 1 ATOM 1758 O O . ALA A 1 291 ? -60.094 -26.649 34.407 1.00 51.69 ? 264 ALA B O 1 ATOM 1759 C CB . ALA A 1 291 ? -58.565 -28.841 35.872 1.00 60.06 ? 264 ALA B CB 1 ATOM 1760 N N . LYS A 1 292 ? -59.658 -25.776 36.424 1.00 51.59 ? 265 LYS B N 1 ATOM 1761 C CA . LYS A 1 292 ? -59.630 -24.383 36.024 1.00 57.27 ? 265 LYS B CA 1 ATOM 1762 C C . LYS A 1 292 ? -58.154 -23.936 35.944 1.00 58.02 ? 265 LYS B C 1 ATOM 1763 O O . LYS A 1 292 ? -57.797 -23.069 35.116 1.00 61.34 ? 265 LYS B O 1 ATOM 1764 C CB . LYS A 1 292 ? -60.416 -23.523 37.057 1.00 56.51 ? 265 LYS B CB 1 ATOM 1765 C CG . LYS A 1 292 ? -60.897 -22.143 36.584 1.00 61.70 ? 265 LYS B CG 1 ATOM 1766 C CD . LYS A 1 292 ? -60.968 -21.097 37.722 1.00 68.01 ? 265 LYS B CD 1 ATOM 1767 C CE . LYS A 1 292 ? -62.050 -20.005 37.562 1.00 65.38 ? 265 LYS B CE 1 ATOM 1768 N NZ . LYS A 1 292 ? -61.869 -19.035 36.434 1.00 65.41 ? 265 LYS B NZ 1 ATOM 1769 N N . VAL A 1 293 ? -57.306 -24.512 36.803 1.00 51.16 ? 266 VAL B N 1 ATOM 1770 C CA . VAL A 1 293 ? -55.890 -24.152 36.849 1.00 54.37 ? 266 VAL B CA 1 ATOM 1771 C C . VAL A 1 293 ? -55.033 -25.116 36.037 1.00 55.38 ? 266 VAL B C 1 ATOM 1772 O O . VAL A 1 293 ? -55.013 -26.320 36.285 1.00 52.56 ? 266 VAL B O 1 ATOM 1773 C CB . VAL A 1 293 ? -55.358 -24.072 38.283 1.00 53.00 ? 266 VAL B CB 1 ATOM 1774 C CG1 . VAL A 1 293 ? -53.864 -23.812 38.291 1.00 52.62 ? 266 VAL B CG1 1 ATOM 1775 C CG2 . VAL A 1 293 ? -56.058 -22.946 39.008 1.00 59.29 ? 266 VAL B CG2 1 ATOM 1776 N N . ILE A 1 294 ? -54.291 -24.564 35.088 1.00 54.80 ? 267 ILE B N 1 ATOM 1777 C CA . ILE A 1 294 ? -53.524 -25.381 34.173 1.00 52.50 ? 267 ILE B CA 1 ATOM 1778 C C . ILE A 1 294 ? -52.093 -24.911 34.212 1.00 48.33 ? 267 ILE B C 1 ATOM 1779 O O . ILE A 1 294 ? -51.811 -23.748 33.915 1.00 47.51 ? 267 ILE B O 1 ATOM 1780 C CB . ILE A 1 294 ? -54.098 -25.278 32.768 1.00 52.79 ? 267 ILE B CB 1 ATOM 1781 C CG1 . ILE A 1 294 ? -55.561 -25.755 32.809 1.00 55.51 ? 267 ILE B CG1 1 ATOM 1782 C CG2 . ILE A 1 294 ? -53.259 -26.077 31.786 1.00 49.84 ? 267 ILE B CG2 1 ATOM 1783 C CD1 . ILE A 1 294 ? -56.227 -25.803 31.442 1.00 57.18 ? 267 ILE B CD1 1 ATOM 1784 N N . VAL A 1 295 ? -51.212 -25.820 34.630 1.00 47.13 ? 268 VAL B N 1 ATOM 1785 C CA . VAL A 1 295 ? -49.790 -25.567 34.711 1.00 45.99 ? 268 VAL B CA 1 ATOM 1786 C C . VAL A 1 295 ? -49.149 -26.004 33.412 1.00 45.47 ? 268 VAL B C 1 ATOM 1787 O O . VAL A 1 295 ? -49.322 -27.147 33.004 1.00 48.16 ? 268 VAL B O 1 ATOM 1788 C CB . VAL A 1 295 ? -49.167 -26.392 35.824 1.00 43.42 ? 268 VAL B CB 1 ATOM 1789 C CG1 . VAL A 1 295 ? -47.669 -26.170 35.870 1.00 40.80 ? 268 VAL B CG1 1 ATOM 1790 C CG2 . VAL A 1 295 ? -49.817 -26.035 37.145 1.00 44.35 ? 268 VAL B CG2 1 ATOM 1791 N N . VAL A 1 296 ? -48.413 -25.097 32.784 1.00 42.93 ? 269 VAL B N 1 ATOM 1792 C CA . VAL A 1 296 ? -47.805 -25.339 31.493 1.00 44.78 ? 269 VAL B CA 1 ATOM 1793 C C . VAL A 1 296 ? -46.298 -25.101 31.532 1.00 46.16 ? 269 VAL B C 1 ATOM 1794 O O . VAL A 1 296 ? -45.850 -24.002 31.844 1.00 51.21 ? 269 VAL B O 1 ATOM 1795 C CB . VAL A 1 296 ? -48.409 -24.403 30.443 1.00 49.46 ? 269 VAL B CB 1 ATOM 1796 C CG1 . VAL A 1 296 ? -47.873 -24.743 29.055 1.00 48.38 ? 269 VAL B CG1 1 ATOM 1797 C CG2 . VAL A 1 296 ? -49.947 -24.449 30.497 1.00 47.98 ? 269 VAL B CG2 1 ATOM 1798 N N . PHE A 1 297 ? -45.525 -26.141 31.213 1.00 47.14 ? 270 PHE B N 1 ATOM 1799 C CA . PHE A 1 297 ? -44.075 -26.093 31.226 1.00 44.67 ? 270 PHE B CA 1 ATOM 1800 C C . PHE A 1 297 ? -43.532 -26.211 29.810 1.00 45.32 ? 270 PHE B C 1 ATOM 1801 O O . PHE A 1 297 ? -43.385 -27.308 29.274 1.00 45.07 ? 270 PHE B O 1 ATOM 1802 C CB . PHE A 1 297 ? -43.540 -27.202 32.097 1.00 45.93 ? 270 PHE B CB 1 ATOM 1803 C CG . PHE A 1 297 ? -42.485 -26.740 33.058 1.00 53.52 ? 270 PHE B CG 1 ATOM 1804 C CD1 . PHE A 1 297 ? -41.245 -26.277 32.580 1.00 53.16 ? 270 PHE B CD1 1 ATOM 1805 C CD2 . PHE A 1 297 ? -42.725 -26.738 34.437 1.00 53.63 ? 270 PHE B CD2 1 ATOM 1806 C CE1 . PHE A 1 297 ? -40.264 -25.843 33.449 1.00 51.51 ? 270 PHE B CE1 1 ATOM 1807 C CE2 . PHE A 1 297 ? -41.750 -26.277 35.307 1.00 58.99 ? 270 PHE B CE2 1 ATOM 1808 C CZ . PHE A 1 297 ? -40.518 -25.838 34.813 1.00 56.65 ? 270 PHE B CZ 1 ATOM 1809 N N . SER A 1 298 ? -43.257 -25.076 29.186 1.00 42.82 ? 271 SER B N 1 ATOM 1810 C CA . SER A 1 298 ? -42.999 -25.092 27.761 1.00 43.35 ? 271 SER B CA 1 ATOM 1811 C C . SER A 1 298 ? -42.484 -23.785 27.240 1.00 44.26 ? 271 SER B C 1 ATOM 1812 O O . SER A 1 298 ? -42.664 -22.736 27.843 1.00 50.43 ? 271 SER B O 1 ATOM 1813 C CB . SER A 1 298 ? -44.292 -25.384 27.025 1.00 42.11 ? 271 SER B CB 1 ATOM 1814 O OG . SER A 1 298 ? -44.146 -25.138 25.646 1.00 38.57 ? 271 SER B OG 1 ATOM 1815 N N . SER A 1 299 ? -41.853 -23.862 26.091 1.00 43.60 ? 272 SER B N 1 ATOM 1816 C CA . SER A 1 299 ? -41.433 -22.685 25.361 1.00 43.61 ? 272 SER B CA 1 ATOM 1817 C C . SER A 1 299 ? -42.619 -22.151 24.583 1.00 44.91 ? 272 SER B C 1 ATOM 1818 O O . SER A 1 299 ? -43.635 -22.844 24.442 1.00 40.15 ? 272 SER B O 1 ATOM 1819 C CB . SER A 1 299 ? -40.371 -23.072 24.362 1.00 42.95 ? 272 SER B CB 1 ATOM 1820 O OG . SER A 1 299 ? -40.929 -23.980 23.406 1.00 45.87 ? 272 SER B OG 1 ATOM 1821 N N . GLY A 1 300 ? -42.462 -20.930 24.062 1.00 45.01 ? 273 GLY B N 1 ATOM 1822 C CA . GLY A 1 300 ? -43.469 -20.290 23.218 1.00 46.61 ? 273 GLY B CA 1 ATOM 1823 C C . GLY A 1 300 ? -43.734 -21.126 21.987 1.00 46.38 ? 273 GLY B C 1 ATOM 1824 O O . GLY A 1 300 ? -44.872 -21.568 21.730 1.00 46.87 ? 273 GLY B O 1 ATOM 1825 N N . PRO A 1 301 ? -42.673 -21.414 21.252 1.00 46.44 ? 274 PRO B N 1 ATOM 1826 C CA . PRO A 1 301 ? -42.893 -22.123 20.013 1.00 45.57 ? 274 PRO B CA 1 ATOM 1827 C C . PRO A 1 301 ? -43.568 -23.467 20.213 1.00 46.01 ? 274 PRO B C 1 ATOM 1828 O O . PRO A 1 301 ? -44.441 -23.810 19.427 1.00 45.17 ? 274 PRO B O 1 ATOM 1829 C CB . PRO A 1 301 ? -41.490 -22.230 19.420 1.00 44.38 ? 274 PRO B CB 1 ATOM 1830 C CG . PRO A 1 301 ? -40.728 -21.067 20.005 1.00 42.73 ? 274 PRO B CG 1 ATOM 1831 C CD . PRO A 1 301 ? -41.285 -20.932 21.385 1.00 46.83 ? 274 PRO B CD 1 ATOM 1832 N N . ASP A 1 302 ? -43.239 -24.203 21.267 1.00 50.35 ? 275 ASP B N 1 ATOM 1833 C CA . ASP A 1 302 ? -43.939 -25.497 21.496 1.00 59.39 ? 275 ASP B CA 1 ATOM 1834 C C . ASP A 1 302 ? -45.408 -25.401 21.979 1.00 52.14 ? 275 ASP B C 1 ATOM 1835 O O . ASP A 1 302 ? -46.142 -26.369 21.926 1.00 50.93 ? 275 ASP B O 1 ATOM 1836 C CB . ASP A 1 302 ? -43.135 -26.388 22.445 1.00 61.45 ? 275 ASP B CB 1 ATOM 1837 C CG . ASP A 1 302 ? -41.784 -26.747 21.871 1.00 70.71 ? 275 ASP B CG 1 ATOM 1838 O OD1 . ASP A 1 302 ? -41.742 -27.198 20.699 1.00 65.51 ? 275 ASP B OD1 1 ATOM 1839 O OD2 . ASP A 1 302 ? -40.769 -26.566 22.584 1.00 77.08 ? 275 ASP B OD2 1 ATOM 1840 N N . LEU A 1 303 ? -45.808 -24.230 22.444 1.00 50.87 ? 276 LEU B N 1 ATOM 1841 C CA . LEU A 1 303 ? -47.138 -23.997 22.976 1.00 54.01 ? 276 LEU B CA 1 ATOM 1842 C C . LEU A 1 303 ? -48.108 -23.298 21.974 1.00 58.11 ? 276 LEU B C 1 ATOM 1843 O O . LEU A 1 303 ? -49.329 -23.441 22.085 1.00 56.09 ? 276 LEU B O 1 ATOM 1844 C CB . LEU A 1 303 ? -46.992 -23.129 24.215 1.00 53.24 ? 276 LEU B CB 1 ATOM 1845 C CG . LEU A 1 303 ? -48.261 -22.743 24.947 1.00 48.22 ? 276 LEU B CG 1 ATOM 1846 C CD1 . LEU A 1 303 ? -48.960 -24.011 25.371 1.00 49.55 ? 276 LEU B CD1 1 ATOM 1847 C CD2 . LEU A 1 303 ? -47.936 -21.854 26.140 1.00 46.58 ? 276 LEU B CD2 1 ATOM 1848 N N . GLU A 1 304 ? -47.559 -22.563 21.005 1.00 58.88 ? 277 GLU B N 1 ATOM 1849 C CA . GLU A 1 304 ? -48.357 -21.734 20.087 1.00 60.28 ? 277 GLU B CA 1 ATOM 1850 C C . GLU A 1 304 ? -49.459 -22.504 19.326 1.00 55.81 ? 277 GLU B C 1 ATOM 1851 O O . GLU A 1 304 ? -50.589 -22.044 19.277 1.00 62.26 ? 277 GLU B O 1 ATOM 1852 C CB . GLU A 1 304 ? -47.451 -20.905 19.148 1.00 60.05 ? 277 GLU B CB 1 ATOM 1853 C CG . GLU A 1 304 ? -48.199 -20.230 18.017 1.00 67.33 ? 277 GLU B CG 1 ATOM 1854 C CD . GLU A 1 304 ? -47.353 -19.249 17.205 1.00 74.31 ? 277 GLU B CD 1 ATOM 1855 O OE1 . GLU A 1 304 ? -46.359 -19.702 16.596 1.00 70.18 ? 277 GLU B OE1 1 ATOM 1856 O OE2 . GLU A 1 304 ? -47.696 -18.030 17.149 1.00 72.96 ? 277 GLU B OE2 1 ATOM 1857 N N . PRO A 1 305 ? -49.153 -23.672 18.754 1.00 53.36 ? 278 PRO B N 1 ATOM 1858 C CA . PRO A 1 305 ? -50.241 -24.460 18.153 1.00 52.60 ? 278 PRO B CA 1 ATOM 1859 C C . PRO A 1 305 ? -51.373 -24.820 19.129 1.00 53.45 ? 278 PRO B C 1 ATOM 1860 O O . PRO A 1 305 ? -52.528 -24.723 18.766 1.00 57.82 ? 278 PRO B O 1 ATOM 1861 C CB . PRO A 1 305 ? -49.556 -25.757 17.674 1.00 51.07 ? 278 PRO B CB 1 ATOM 1862 C CG . PRO A 1 305 ? -48.098 -25.458 17.648 1.00 53.10 ? 278 PRO B CG 1 ATOM 1863 C CD . PRO A 1 305 ? -47.838 -24.322 18.605 1.00 55.78 ? 278 PRO B CD 1 ATOM 1864 N N . LEU A 1 306 ? -51.075 -25.246 20.346 1.00 55.95 ? 279 LEU B N 1 ATOM 1865 C CA . LEU A 1 306 ? -52.172 -25.582 21.251 1.00 58.81 ? 279 LEU B CA 1 ATOM 1866 C C . LEU A 1 306 ? -52.984 -24.340 21.492 1.00 56.79 ? 279 LEU B C 1 ATOM 1867 O O . LEU A 1 306 ? -54.168 -24.380 21.362 1.00 58.95 ? 279 LEU B O 1 ATOM 1868 C CB . LEU A 1 306 ? -51.698 -26.149 22.576 1.00 63.82 ? 279 LEU B CB 1 ATOM 1869 C CG . LEU A 1 306 ? -52.774 -26.314 23.668 1.00 65.93 ? 279 LEU B CG 1 ATOM 1870 C CD1 . LEU A 1 306 ? -53.792 -27.378 23.316 1.00 61.43 ? 279 LEU B CD1 1 ATOM 1871 C CD2 . LEU A 1 306 ? -52.098 -26.637 24.996 1.00 64.26 ? 279 LEU B CD2 1 ATOM 1872 N N . ILE A 1 307 ? -52.335 -23.231 21.809 1.00 58.83 ? 280 ILE B N 1 ATOM 1873 C CA . ILE A 1 307 ? -53.043 -21.989 22.100 1.00 61.41 ? 280 ILE B CA 1 ATOM 1874 C C . ILE A 1 307 ? -53.902 -21.495 20.941 1.00 59.43 ? 280 ILE B C 1 ATOM 1875 O O . ILE A 1 307 ? -55.016 -21.054 21.152 1.00 50.45 ? 280 ILE B O 1 ATOM 1876 C CB . ILE A 1 307 ? -52.062 -20.901 22.534 1.00 63.79 ? 280 ILE B CB 1 ATOM 1877 C CG1 . ILE A 1 307 ? -51.538 -21.229 23.939 1.00 70.95 ? 280 ILE B CG1 1 ATOM 1878 C CG2 . ILE A 1 307 ? -52.705 -19.530 22.506 1.00 64.65 ? 280 ILE B CG2 1 ATOM 1879 C CD1 . ILE A 1 307 ? -52.567 -21.213 25.055 1.00 70.66 ? 280 ILE B CD1 1 ATOM 1880 N N . LYS A 1 308 ? -53.395 -21.570 19.721 1.00 62.42 ? 281 LYS B N 1 ATOM 1881 C CA . LYS A 1 308 ? -54.201 -21.178 18.572 1.00 60.37 ? 281 LYS B CA 1 ATOM 1882 C C . LYS A 1 308 ? -55.536 -21.909 18.560 1.00 56.82 ? 281 LYS B C 1 ATOM 1883 O O . LYS A 1 308 ? -56.576 -21.294 18.408 1.00 60.31 ? 281 LYS B O 1 ATOM 1884 C CB . LYS A 1 308 ? -53.444 -21.398 17.267 1.00 58.11 ? 281 LYS B CB 1 ATOM 1885 C CG . LYS A 1 308 ? -52.411 -20.316 17.043 1.00 65.52 ? 281 LYS B CG 1 ATOM 1886 C CD . LYS A 1 308 ? -51.667 -20.479 15.727 1.00 70.86 ? 281 LYS B CD 1 ATOM 1887 C CE . LYS A 1 308 ? -50.764 -19.273 15.483 1.00 77.97 ? 281 LYS B CE 1 ATOM 1888 N NZ . LYS A 1 308 ? -49.667 -19.520 14.505 1.00 83.54 ? 281 LYS B NZ 1 ATOM 1889 N N . GLU A 1 309 ? -55.522 -23.213 18.745 1.00 56.03 ? 282 GLU B N 1 ATOM 1890 C CA . GLU A 1 309 ? -56.780 -23.974 18.773 1.00 62.31 ? 282 GLU B CA 1 ATOM 1891 C C . GLU A 1 309 ? -57.702 -23.643 19.972 1.00 64.21 ? 282 GLU B C 1 ATOM 1892 O O . GLU A 1 309 ? -58.922 -23.689 19.862 1.00 70.04 ? 282 GLU B O 1 ATOM 1893 C CB . GLU A 1 309 ? -56.486 -25.464 18.787 1.00 60.69 ? 282 GLU B CB 1 ATOM 1894 C CG . GLU A 1 309 ? -57.713 -26.324 18.566 1.00 70.75 ? 282 GLU B CG 1 ATOM 1895 C CD . GLU A 1 309 ? -58.383 -26.113 17.213 1.00 75.15 ? 282 GLU B CD 1 ATOM 1896 O OE1 . GLU A 1 309 ? -59.545 -26.567 17.079 1.00 77.41 ? 282 GLU B OE1 1 ATOM 1897 O OE2 . GLU A 1 309 ? -57.758 -25.519 16.294 1.00 76.10 ? 282 GLU B OE2 1 ATOM 1898 N N . ILE A 1 310 ? -57.110 -23.320 21.108 1.00 60.73 ? 283 ILE B N 1 ATOM 1899 C CA . ILE A 1 310 ? -57.850 -23.029 22.311 1.00 62.03 ? 283 ILE B CA 1 ATOM 1900 C C . ILE A 1 310 ? -58.577 -21.698 22.127 1.00 59.28 ? 283 ILE B C 1 ATOM 1901 O O . ILE A 1 310 ? -59.712 -21.529 22.539 1.00 59.69 ? 283 ILE B O 1 ATOM 1902 C CB . ILE A 1 310 ? -56.897 -23.040 23.531 1.00 62.44 ? 283 ILE B CB 1 ATOM 1903 C CG1 . ILE A 1 310 ? -56.564 -24.494 23.870 1.00 71.47 ? 283 ILE B CG1 1 ATOM 1904 C CG2 . ILE A 1 310 ? -57.526 -22.395 24.756 1.00 68.95 ? 283 ILE B CG2 1 ATOM 1905 C CD1 . ILE A 1 310 ? -55.662 -24.715 25.075 1.00 76.07 ? 283 ILE B CD1 1 ATOM 1906 N N . VAL A 1 311 ? -57.897 -20.769 21.492 1.00 59.48 ? 284 VAL B N 1 ATOM 1907 C CA . VAL A 1 311 ? -58.481 -19.507 21.062 1.00 59.29 ? 284 VAL B CA 1 ATOM 1908 C C . VAL A 1 311 ? -59.569 -19.703 19.994 1.00 61.54 ? 284 VAL B C 1 ATOM 1909 O O . VAL A 1 311 ? -60.593 -19.035 20.021 1.00 61.86 ? 284 VAL B O 1 ATOM 1910 C CB . VAL A 1 311 ? -57.383 -18.599 20.506 1.00 51.82 ? 284 VAL B CB 1 ATOM 1911 C CG1 . VAL A 1 311 ? -57.981 -17.374 19.897 1.00 52.31 ? 284 VAL B CG1 1 ATOM 1912 C CG2 . VAL A 1 311 ? -56.420 -18.215 21.611 1.00 54.38 ? 284 VAL B CG2 1 ATOM 1913 N N . ARG A 1 312 ? -59.345 -20.627 19.071 1.00 66.03 ? 285 ARG B N 1 ATOM 1914 C CA . ARG A 1 312 ? -60.313 -20.913 18.011 1.00 69.01 ? 285 ARG B CA 1 ATOM 1915 C C . ARG A 1 312 ? -61.615 -21.441 18.609 1.00 69.09 ? 285 ARG B C 1 ATOM 1916 O O . ARG A 1 312 ? -62.687 -21.082 18.173 1.00 81.09 ? 285 ARG B O 1 ATOM 1917 C CB . ARG A 1 312 ? -59.746 -21.931 17.017 1.00 73.11 ? 285 ARG B CB 1 ATOM 1918 C CG . ARG A 1 312 ? -59.856 -21.554 15.542 1.00 82.38 ? 285 ARG B CG 1 ATOM 1919 C CD . ARG A 1 312 ? -59.896 -22.804 14.660 1.00 86.21 ? 285 ARG B CD 1 ATOM 1920 N NE . ARG A 1 312 ? -61.083 -23.590 15.006 1.00 96.23 ? 285 ARG B NE 1 ATOM 1921 C CZ . ARG A 1 312 ? -61.197 -24.915 14.932 1.00 99.36 ? 285 ARG B CZ 1 ATOM 1922 N NH1 . ARG A 1 312 ? -62.342 -25.491 15.310 1.00 92.25 ? 285 ARG B NH1 1 ATOM 1923 N NH2 . ARG A 1 312 ? -60.183 -25.669 14.501 1.00 105.85 ? 285 ARG B NH2 1 ATOM 1924 N N . ARG A 1 313 ? -61.528 -22.282 19.623 1.00 67.16 ? 286 ARG B N 1 ATOM 1925 C CA . ARG A 1 313 ? -62.724 -22.811 20.253 1.00 63.85 ? 286 ARG B CA 1 ATOM 1926 C C . ARG A 1 313 ? -63.179 -21.983 21.453 1.00 64.40 ? 286 ARG B C 1 ATOM 1927 O O . ARG A 1 313 ? -63.972 -22.422 22.250 1.00 63.70 ? 286 ARG B O 1 ATOM 1928 C CB . ARG A 1 313 ? -62.461 -24.236 20.680 1.00 67.35 ? 286 ARG B CB 1 ATOM 1929 C CG . ARG A 1 313 ? -61.963 -25.101 19.541 1.00 69.16 ? 286 ARG B CG 1 ATOM 1930 C CD . ARG A 1 313 ? -62.249 -26.549 19.870 1.00 77.65 ? 286 ARG B CD 1 ATOM 1931 N NE . ARG A 1 313 ? -61.587 -27.475 18.967 1.00 84.33 ? 286 ARG B NE 1 ATOM 1932 C CZ . ARG A 1 313 ? -61.746 -28.796 19.010 1.00 93.22 ? 286 ARG B CZ 1 ATOM 1933 N NH1 . ARG A 1 313 ? -62.560 -29.345 19.913 1.00 95.08 ? 286 ARG B NH1 1 ATOM 1934 N NH2 . ARG A 1 313 ? -61.082 -29.579 18.156 1.00 92.16 ? 286 ARG B NH2 1 ATOM 1935 N N . ASN A 1 314 ? -62.651 -20.783 21.593 1.00 68.88 ? 287 ASN B N 1 ATOM 1936 C CA . ASN A 1 314 ? -63.093 -19.865 22.623 1.00 73.72 ? 287 ASN B CA 1 ATOM 1937 C C . ASN A 1 314 ? -63.142 -20.337 24.110 1.00 73.13 ? 287 ASN B C 1 ATOM 1938 O O . ASN A 1 314 ? -63.926 -19.836 24.912 1.00 73.02 ? 287 ASN B O 1 ATOM 1939 C CB . ASN A 1 314 ? -64.440 -19.316 22.206 1.00 79.98 ? 287 ASN B CB 1 ATOM 1940 C CG . ASN A 1 314 ? -64.673 -17.930 22.750 1.00 91.58 ? 287 ASN B CG 1 ATOM 1941 O OD1 . ASN A 1 314 ? -63.786 -17.077 22.663 1.00 81.56 ? 287 ASN B OD1 1 ATOM 1942 N ND2 . ASN A 1 314 ? -65.874 -17.695 23.334 1.00 99.19 ? 287 ASN B ND2 1 ATOM 1943 N N . ILE A 1 315 ? -62.255 -21.247 24.491 1.00 72.14 ? 288 ILE B N 1 ATOM 1944 C CA . ILE A 1 315 ? -62.192 -21.737 25.869 1.00 64.84 ? 288 ILE B CA 1 ATOM 1945 C C . ILE A 1 315 ? -61.663 -20.652 26.813 1.00 65.83 ? 288 ILE B C 1 ATOM 1946 O O . ILE A 1 315 ? -60.570 -20.118 26.618 1.00 68.62 ? 288 ILE B O 1 ATOM 1947 C CB . ILE A 1 315 ? -61.310 -22.987 25.949 1.00 63.80 ? 288 ILE B CB 1 ATOM 1948 C CG1 . ILE A 1 315 ? -61.951 -24.118 25.139 1.00 66.94 ? 288 ILE B CG1 1 ATOM 1949 C CG2 . ILE A 1 315 ? -61.098 -23.405 27.398 1.00 61.11 ? 288 ILE B CG2 1 ATOM 1950 C CD1 . ILE A 1 315 ? -61.026 -25.290 24.886 1.00 71.36 ? 288 ILE B CD1 1 ATOM 1951 N N . THR A 1 316 ? -62.423 -20.388 27.870 1.00 64.11 ? 289 THR B N 1 ATOM 1952 C CA . THR A 1 316 ? -62.386 -19.111 28.584 1.00 60.70 ? 289 THR B CA 1 ATOM 1953 C C . THR A 1 316 ? -62.244 -19.282 30.095 1.00 62.36 ? 289 THR B C 1 ATOM 1954 O O . THR A 1 316 ? -62.644 -20.301 30.668 1.00 56.02 ? 289 THR B O 1 ATOM 1955 C CB . THR A 1 316 ? -63.676 -18.327 28.234 1.00 63.88 ? 289 THR B CB 1 ATOM 1956 O OG1 . THR A 1 316 ? -63.379 -17.361 27.231 1.00 64.50 ? 289 THR B OG1 1 ATOM 1957 C CG2 . THR A 1 316 ? -64.328 -17.623 29.440 1.00 70.06 ? 289 THR B CG2 1 ATOM 1958 N N . GLY A 1 317 ? -61.672 -18.267 30.741 1.00 63.44 ? 290 GLY B N 1 ATOM 1959 C CA . GLY A 1 317 ? -61.459 -18.299 32.184 1.00 62.20 ? 290 GLY B CA 1 ATOM 1960 C C . GLY A 1 317 ? -60.854 -19.595 32.682 1.00 67.33 ? 290 GLY B C 1 ATOM 1961 O O . GLY A 1 317 ? -61.434 -20.278 33.515 1.00 73.11 ? 290 GLY B O 1 ATOM 1962 N N . LYS A 1 318 ? -59.701 -19.956 32.128 1.00 71.73 ? 291 LYS B N 1 ATOM 1963 C CA . LYS A 1 318 ? -58.776 -20.853 32.800 1.00 65.04 ? 291 LYS B CA 1 ATOM 1964 C C . LYS A 1 318 ? -57.733 -19.998 33.484 1.00 64.20 ? 291 LYS B C 1 ATOM 1965 O O . LYS A 1 318 ? -57.424 -18.895 33.019 1.00 57.51 ? 291 LYS B O 1 ATOM 1966 C CB . LYS A 1 318 ? -58.059 -21.726 31.800 1.00 66.49 ? 291 LYS B CB 1 ATOM 1967 C CG . LYS A 1 318 ? -58.957 -22.681 31.074 1.00 66.43 ? 291 LYS B CG 1 ATOM 1968 C CD . LYS A 1 318 ? -59.539 -23.678 32.031 1.00 66.86 ? 291 LYS B CD 1 ATOM 1969 C CE . LYS A 1 318 ? -60.488 -24.584 31.299 1.00 71.30 ? 291 LYS B CE 1 ATOM 1970 N NZ . LYS A 1 318 ? -61.223 -25.392 32.297 1.00 77.98 ? 291 LYS B NZ 1 ATOM 1971 N N . ILE A 1 319 ? -57.180 -20.506 34.576 1.00 61.52 ? 292 ILE B N 1 ATOM 1972 C CA . ILE A 1 319 ? -55.990 -19.900 35.171 1.00 58.80 ? 292 ILE B CA 1 ATOM 1973 C C . ILE A 1 319 ? -54.760 -20.646 34.664 1.00 57.83 ? 292 ILE B C 1 ATOM 1974 O O . ILE A 1 319 ? -54.590 -21.847 34.914 1.00 57.52 ? 292 ILE B O 1 ATOM 1975 C CB . ILE A 1 319 ? -56.043 -19.956 36.698 1.00 63.25 ? 292 ILE B CB 1 ATOM 1976 C CG1 . ILE A 1 319 ? -57.368 -19.334 37.169 1.00 65.25 ? 292 ILE B CG1 1 ATOM 1977 C CG2 . ILE A 1 319 ? -54.808 -19.289 37.301 1.00 62.49 ? 292 ILE B CG2 1 ATOM 1978 C CD1 . ILE A 1 319 ? -57.555 -19.277 38.663 1.00 63.32 ? 292 ILE B CD1 1 ATOM 1979 N N . TRP A 1 320 ? -53.921 -19.917 33.927 1.00 59.23 ? 293 TRP B N 1 ATOM 1980 C CA . TRP A 1 320 ? -52.711 -20.448 33.319 1.00 49.94 ? 293 TRP B CA 1 ATOM 1981 C C . TRP A 1 320 ? -51.523 -20.070 34.190 1.00 51.07 ? 293 TRP B C 1 ATOM 1982 O O . TRP A 1 320 ? -51.330 -18.886 34.487 1.00 45.90 ? 293 TRP B O 1 ATOM 1983 C CB . TRP A 1 320 ? -52.508 -19.817 31.970 1.00 47.61 ? 293 TRP B CB 1 ATOM 1984 C CG . TRP A 1 320 ? -53.611 -20.051 30.993 1.00 53.25 ? 293 TRP B CG 1 ATOM 1985 C CD1 . TRP A 1 320 ? -54.571 -19.154 30.605 1.00 52.48 ? 293 TRP B CD1 1 ATOM 1986 C CD2 . TRP A 1 320 ? -53.843 -21.234 30.219 1.00 53.55 ? 293 TRP B CD2 1 ATOM 1987 N NE1 . TRP A 1 320 ? -55.387 -19.715 29.663 1.00 48.27 ? 293 TRP B NE1 1 ATOM 1988 C CE2 . TRP A 1 320 ? -54.964 -20.992 29.412 1.00 52.48 ? 293 TRP B CE2 1 ATOM 1989 C CE3 . TRP A 1 320 ? -53.208 -22.466 30.128 1.00 52.19 ? 293 TRP B CE3 1 ATOM 1990 C CZ2 . TRP A 1 320 ? -55.461 -21.936 28.537 1.00 55.12 ? 293 TRP B CZ2 1 ATOM 1991 C CZ3 . TRP A 1 320 ? -53.698 -23.389 29.262 1.00 57.80 ? 293 TRP B CZ3 1 ATOM 1992 C CH2 . TRP A 1 320 ? -54.817 -23.126 28.474 1.00 56.14 ? 293 TRP B CH2 1 ATOM 1993 N N . LEU A 1 321 ? -50.740 -21.078 34.582 1.00 47.93 ? 294 LEU B N 1 ATOM 1994 C CA . LEU A 1 321 ? -49.508 -20.899 35.321 1.00 46.82 ? 294 LEU B CA 1 ATOM 1995 C C . LEU A 1 321 ? -48.324 -21.202 34.389 1.00 49.24 ? 294 LEU B C 1 ATOM 1996 O O . LEU A 1 321 ? -48.140 -22.355 33.926 1.00 43.10 ? 294 LEU B O 1 ATOM 1997 C CB . LEU A 1 321 ? -49.498 -21.872 36.479 1.00 55.18 ? 294 LEU B CB 1 ATOM 1998 C CG . LEU A 1 321 ? -49.606 -21.329 37.888 1.00 64.81 ? 294 LEU B CG 1 ATOM 1999 C CD1 . LEU A 1 321 ? -50.898 -20.550 38.103 1.00 69.63 ? 294 LEU B CD1 1 ATOM 2000 C CD2 . LEU A 1 321 ? -49.524 -22.528 38.823 1.00 70.98 ? 294 LEU B CD2 1 ATOM 2001 N N . ALA A 1 322 ? -47.513 -20.183 34.122 1.00 47.24 ? 295 ALA B N 1 ATOM 2002 C CA . ALA A 1 322 ? -46.529 -20.247 33.034 1.00 49.35 ? 295 ALA B CA 1 ATOM 2003 C C . ALA A 1 322 ? -45.152 -20.470 33.568 1.00 49.38 ? 295 ALA B C 1 ATOM 2004 O O . ALA A 1 322 ? -44.759 -19.818 34.545 1.00 48.11 ? 295 ALA B O 1 ATOM 2005 C CB . ALA A 1 322 ? -46.539 -18.967 32.220 1.00 51.08 ? 295 ALA B CB 1 ATOM 2006 N N . SER A 1 323 ? -44.418 -21.376 32.925 1.00 44.98 ? 296 SER B N 1 ATOM 2007 C CA . SER A 1 323 ? -43.012 -21.559 33.241 1.00 44.56 ? 296 SER B CA 1 ATOM 2008 C C . SER A 1 323 ? -42.295 -20.370 32.620 1.00 45.62 ? 296 SER B C 1 ATOM 2009 O O . SER A 1 323 ? -42.865 -19.698 31.757 1.00 47.45 ? 296 SER B O 1 ATOM 2010 C CB . SER A 1 323 ? -42.484 -22.922 32.708 1.00 46.25 ? 296 SER B CB 1 ATOM 2011 O OG . SER A 1 323 ? -42.247 -22.934 31.286 1.00 50.25 ? 296 SER B OG 1 ATOM 2012 N N . GLU A 1 324 ? -41.052 -20.104 32.999 1.00 50.20 ? 297 GLU B N 1 ATOM 2013 C CA . GLU A 1 324 ? -40.400 -18.855 32.590 1.00 52.62 ? 297 GLU B CA 1 ATOM 2014 C C . GLU A 1 324 ? -40.210 -18.761 31.082 1.00 50.08 ? 297 GLU B C 1 ATOM 2015 O O . GLU A 1 324 ? -40.079 -17.680 30.548 1.00 53.62 ? 297 GLU B O 1 ATOM 2016 C CB . GLU A 1 324 ? -39.077 -18.636 33.339 1.00 61.26 ? 297 GLU B CB 1 ATOM 2017 C CG . GLU A 1 324 ? -37.783 -19.100 32.648 1.00 77.58 ? 297 GLU B CG 1 ATOM 2018 C CD . GLU A 1 324 ? -37.502 -20.595 32.815 1.00 88.13 ? 297 GLU B CD 1 ATOM 2019 O OE1 . GLU A 1 324 ? -36.722 -20.977 33.739 1.00 94.33 ? 297 GLU B OE1 1 ATOM 2020 O OE2 . GLU A 1 324 ? -38.065 -21.385 32.017 1.00 87.31 ? 297 GLU B OE2 1 ATOM 2021 N N . ALA A 1 325 ? -40.215 -19.890 30.394 1.00 51.37 ? 298 ALA B N 1 ATOM 2022 C CA . ALA A 1 325 ? -39.956 -19.892 28.956 1.00 54.76 ? 298 ALA B CA 1 ATOM 2023 C C . ALA A 1 325 ? -41.085 -19.305 28.124 1.00 52.42 ? 298 ALA B C 1 ATOM 2024 O O . ALA A 1 325 ? -40.843 -18.751 27.051 1.00 58.77 ? 298 ALA B O 1 ATOM 2025 C CB . ALA A 1 325 ? -39.666 -21.302 28.485 1.00 58.08 ? 298 ALA B CB 1 ATOM 2026 N N . TRP A 1 326 ? -42.324 -19.443 28.575 1.00 47.69 ? 299 TRP B N 1 ATOM 2027 C CA . TRP A 1 326 ? -43.416 -18.809 27.836 1.00 45.87 ? 299 TRP B CA 1 ATOM 2028 C C . TRP A 1 326 ? -44.050 -17.661 28.537 1.00 41.84 ? 299 TRP B C 1 ATOM 2029 O O . TRP A 1 326 ? -44.775 -16.926 27.918 1.00 43.56 ? 299 TRP B O 1 ATOM 2030 C CB . TRP A 1 326 ? -44.465 -19.803 27.339 1.00 45.88 ? 299 TRP B CB 1 ATOM 2031 C CG . TRP A 1 326 ? -45.441 -20.348 28.311 1.00 50.24 ? 299 TRP B CG 1 ATOM 2032 C CD1 . TRP A 1 326 ? -45.304 -21.475 29.080 1.00 51.02 ? 299 TRP B CD1 1 ATOM 2033 C CD2 . TRP A 1 326 ? -46.752 -19.839 28.584 1.00 52.67 ? 299 TRP B CD2 1 ATOM 2034 N NE1 . TRP A 1 326 ? -46.441 -21.688 29.815 1.00 50.10 ? 299 TRP B NE1 1 ATOM 2035 C CE2 . TRP A 1 326 ? -47.345 -20.702 29.525 1.00 51.01 ? 299 TRP B CE2 1 ATOM 2036 C CE3 . TRP A 1 326 ? -47.482 -18.738 28.123 1.00 48.03 ? 299 TRP B CE3 1 ATOM 2037 C CZ2 . TRP A 1 326 ? -48.611 -20.481 30.021 1.00 52.39 ? 299 TRP B CZ2 1 ATOM 2038 C CZ3 . TRP A 1 326 ? -48.739 -18.526 28.612 1.00 43.54 ? 299 TRP B CZ3 1 ATOM 2039 C CH2 . TRP A 1 326 ? -49.295 -19.391 29.540 1.00 51.31 ? 299 TRP B CH2 1 ATOM 2040 N N . ALA A 1 327 ? -43.699 -17.438 29.789 1.00 44.58 ? 300 ALA B N 1 ATOM 2041 C CA . ALA A 1 327 ? -44.336 -16.390 30.573 1.00 46.81 ? 300 ALA B CA 1 ATOM 2042 C C . ALA A 1 327 ? -44.072 -14.991 30.062 1.00 46.27 ? 300 ALA B C 1 ATOM 2043 O O . ALA A 1 327 ? -44.765 -14.087 30.484 1.00 52.62 ? 300 ALA B O 1 ATOM 2044 C CB . ALA A 1 327 ? -43.923 -16.497 32.035 1.00 49.75 ? 300 ALA B CB 1 ATOM 2045 N N . SER A 1 328 ? -43.093 -14.806 29.167 1.00 51.54 ? 301 SER B N 1 ATOM 2046 C CA . SER A 1 328 ? -42.766 -13.470 28.580 1.00 52.35 ? 301 SER B CA 1 ATOM 2047 C C . SER A 1 328 ? -42.703 -13.521 27.063 1.00 56.05 ? 301 SER B C 1 ATOM 2048 O O . SER A 1 328 ? -42.088 -12.654 26.433 1.00 52.82 ? 301 SER B O 1 ATOM 2049 C CB . SER A 1 328 ? -41.412 -12.987 29.068 1.00 50.66 ? 301 SER B CB 1 ATOM 2050 O OG . SER A 1 328 ? -41.414 -12.885 30.464 1.00 53.50 ? 301 SER B OG 1 ATOM 2051 N N . SER A 1 329 ? -43.325 -14.547 26.485 1.00 57.65 ? 302 SER B N 1 ATOM 2052 C CA . SER A 1 329 ? -43.148 -14.854 25.077 1.00 54.81 ? 302 SER B CA 1 ATOM 2053 C C . SER A 1 329 ? -44.140 -14.063 24.233 1.00 60.29 ? 302 SER B C 1 ATOM 2054 O O . SER A 1 329 ? -45.350 -14.115 24.465 1.00 59.57 ? 302 SER B O 1 ATOM 2055 C CB . SER A 1 329 ? -43.345 -16.342 24.832 1.00 50.79 ? 302 SER B CB 1 ATOM 2056 O OG . SER A 1 329 ? -43.386 -16.615 23.446 1.00 49.53 ? 302 SER B OG 1 ATOM 2057 N N . SER A 1 330 ? -43.620 -13.361 23.232 1.00 59.48 ? 303 SER B N 1 ATOM 2058 C CA . SER A 1 330 ? -44.436 -12.533 22.365 1.00 60.28 ? 303 SER B CA 1 ATOM 2059 C C . SER A 1 330 ? -45.270 -13.362 21.403 1.00 58.54 ? 303 SER B C 1 ATOM 2060 O O . SER A 1 330 ? -46.221 -12.856 20.832 1.00 73.15 ? 303 SER B O 1 ATOM 2061 C CB . SER A 1 330 ? -43.557 -11.557 21.589 1.00 62.19 ? 303 SER B CB 1 ATOM 2062 O OG . SER A 1 330 ? -42.797 -12.255 20.639 1.00 66.17 ? 303 SER B OG 1 ATOM 2063 N N . LEU A 1 331 ? -44.922 -14.628 21.218 1.00 60.86 ? 304 LEU B N 1 ATOM 2064 C CA . LEU A 1 331 ? -45.781 -15.569 20.481 1.00 59.01 ? 304 LEU B CA 1 ATOM 2065 C C . LEU A 1 331 ? -47.090 -15.948 21.177 1.00 54.46 ? 304 LEU B C 1 ATOM 2066 O O . LEU A 1 331 ? -48.001 -16.443 20.525 1.00 61.38 ? 304 LEU B O 1 ATOM 2067 C CB . LEU A 1 331 ? -45.019 -16.855 20.182 1.00 57.40 ? 304 LEU B CB 1 ATOM 2068 C CG . LEU A 1 331 ? -43.859 -16.649 19.222 1.00 61.05 ? 304 LEU B CG 1 ATOM 2069 C CD1 . LEU A 1 331 ? -43.019 -17.925 19.113 1.00 66.41 ? 304 LEU B CD1 1 ATOM 2070 C CD2 . LEU A 1 331 ? -44.367 -16.202 17.858 1.00 57.29 ? 304 LEU B CD2 1 ATOM 2071 N N . ILE A 1 332 ? -47.173 -15.771 22.489 1.00 55.19 ? 305 ILE B N 1 ATOM 2072 C CA . ILE A 1 332 ? -48.380 -16.150 23.243 1.00 54.53 ? 305 ILE B CA 1 ATOM 2073 C C . ILE A 1 332 ? -49.059 -14.918 23.850 1.00 56.80 ? 305 ILE B C 1 ATOM 2074 O O . ILE A 1 332 ? -50.283 -14.828 23.902 1.00 57.52 ? 305 ILE B O 1 ATOM 2075 C CB . ILE A 1 332 ? -48.061 -17.169 24.364 1.00 55.43 ? 305 ILE B CB 1 ATOM 2076 C CG1 . ILE A 1 332 ? -47.167 -18.339 23.869 1.00 53.30 ? 305 ILE B CG1 1 ATOM 2077 C CG2 . ILE A 1 332 ? -49.341 -17.677 25.011 1.00 55.98 ? 305 ILE B CG2 1 ATOM 2078 C CD1 . ILE A 1 332 ? -47.728 -19.216 22.771 1.00 50.20 ? 305 ILE B CD1 1 ATOM 2079 N N . ALA A 1 333 ? -48.265 -13.960 24.296 1.00 62.11 ? 306 ALA B N 1 ATOM 2080 C CA . ALA A 1 333 ? -48.784 -12.728 24.869 1.00 63.43 ? 306 ALA B CA 1 ATOM 2081 C C . ALA A 1 333 ? -49.169 -11.805 23.738 1.00 59.26 ? 306 ALA B C 1 ATOM 2082 O O . ALA A 1 333 ? -48.505 -10.787 23.517 1.00 54.36 ? 306 ALA B O 1 ATOM 2083 C CB . ALA A 1 333 ? -47.737 -12.065 25.771 1.00 61.16 ? 306 ALA B CB 1 ATOM 2084 N N . MET A 1 334 ? -50.254 -12.164 23.048 1.00 63.26 ? 307 MET B N 1 ATOM 2085 C CA . MET A 1 334 ? -50.797 -11.406 21.895 1.00 63.54 ? 307 MET B CA 1 ATOM 2086 C C . MET A 1 334 ? -52.213 -10.948 22.217 1.00 58.04 ? 307 MET B C 1 ATOM 2087 O O . MET A 1 334 ? -53.015 -11.755 22.679 1.00 60.93 ? 307 MET B O 1 ATOM 2088 C CB . MET A 1 334 ? -50.843 -12.284 20.644 1.00 60.99 ? 307 MET B CB 1 ATOM 2089 C CG . MET A 1 334 ? -49.482 -12.658 20.108 1.00 66.92 ? 307 MET B CG 1 ATOM 2090 S SD . MET A 1 334 ? -49.522 -13.053 18.344 1.00 78.43 ? 307 MET B SD 1 ATOM 2091 C CE . MET A 1 334 ? -49.508 -11.382 17.693 1.00 81.28 ? 307 MET B CE 1 ATOM 2092 N N . PRO A 1 335 ? -52.549 -9.674 21.935 1.00 58.22 ? 308 PRO B N 1 ATOM 2093 C CA . PRO A 1 335 ? -53.850 -9.159 22.356 1.00 56.47 ? 308 PRO B CA 1 ATOM 2094 C C . PRO A 1 335 ? -55.063 -9.944 21.830 1.00 57.02 ? 308 PRO B C 1 ATOM 2095 O O . PRO A 1 335 ? -56.055 -10.095 22.538 1.00 56.25 ? 308 PRO B O 1 ATOM 2096 C CB . PRO A 1 335 ? -53.852 -7.728 21.810 1.00 54.32 ? 308 PRO B CB 1 ATOM 2097 C CG . PRO A 1 335 ? -52.427 -7.392 21.602 1.00 58.53 ? 308 PRO B CG 1 ATOM 2098 C CD . PRO A 1 335 ? -51.860 -8.686 21.092 1.00 60.83 ? 308 PRO B CD 1 ATOM 2099 N N . GLN A 1 336 ? -54.994 -10.484 20.626 1.00 59.72 ? 309 GLN B N 1 ATOM 2100 C CA . GLN A 1 336 ? -56.125 -11.283 20.162 1.00 65.63 ? 309 GLN B CA 1 ATOM 2101 C C . GLN A 1 336 ? -56.303 -12.625 20.884 1.00 68.86 ? 309 GLN B C 1 ATOM 2102 O O . GLN A 1 336 ? -57.291 -13.333 20.630 1.00 73.85 ? 309 GLN B O 1 ATOM 2103 C CB . GLN A 1 336 ? -56.068 -11.510 18.654 1.00 67.93 ? 309 GLN B CB 1 ATOM 2104 C CG . GLN A 1 336 ? -55.060 -12.530 18.192 1.00 69.17 ? 309 GLN B CG 1 ATOM 2105 C CD . GLN A 1 336 ? -53.789 -11.883 17.730 1.00 75.61 ? 309 GLN B CD 1 ATOM 2106 O OE1 . GLN A 1 336 ? -53.456 -10.749 18.143 1.00 74.95 ? 309 GLN B OE1 1 ATOM 2107 N NE2 . GLN A 1 336 ? -53.059 -12.590 16.864 1.00 74.50 ? 309 GLN B NE2 1 ATOM 2108 N N . TYR A 1 337 ? -55.350 -13.006 21.741 1.00 65.52 ? 310 TYR B N 1 ATOM 2109 C CA . TYR A 1 337 ? -55.530 -14.200 22.552 1.00 63.46 ? 310 TYR B CA 1 ATOM 2110 C C . TYR A 1 337 ? -56.000 -13.870 23.974 1.00 62.82 ? 310 TYR B C 1 ATOM 2111 O O . TYR A 1 337 ? -56.291 -14.789 24.754 1.00 59.47 ? 310 TYR B O 1 ATOM 2112 C CB . TYR A 1 337 ? -54.262 -15.020 22.636 1.00 60.11 ? 310 TYR B CB 1 ATOM 2113 C CG . TYR A 1 337 ? -53.646 -15.519 21.339 1.00 64.31 ? 310 TYR B CG 1 ATOM 2114 C CD1 . TYR A 1 337 ? -54.365 -15.620 20.145 1.00 64.23 ? 310 TYR B CD1 1 ATOM 2115 C CD2 . TYR A 1 337 ? -52.314 -15.923 21.324 1.00 63.98 ? 310 TYR B CD2 1 ATOM 2116 C CE1 . TYR A 1 337 ? -53.752 -16.103 18.981 1.00 61.67 ? 310 TYR B CE1 1 ATOM 2117 C CE2 . TYR A 1 337 ? -51.711 -16.389 20.175 1.00 66.61 ? 310 TYR B CE2 1 ATOM 2118 C CZ . TYR A 1 337 ? -52.423 -16.487 19.011 1.00 61.63 ? 310 TYR B CZ 1 ATOM 2119 O OH . TYR A 1 337 ? -51.756 -16.981 17.913 1.00 61.61 ? 310 TYR B OH 1 ATOM 2120 N N . PHE A 1 338 ? -56.136 -12.582 24.299 1.00 56.88 ? 311 PHE B N 1 ATOM 2121 C CA . PHE A 1 338 ? -56.269 -12.183 25.692 1.00 58.18 ? 311 PHE B CA 1 ATOM 2122 C C . PHE A 1 338 ? -57.469 -12.756 26.402 1.00 55.35 ? 311 PHE B C 1 ATOM 2123 O O . PHE A 1 338 ? -57.459 -12.905 27.614 1.00 56.34 ? 311 PHE B O 1 ATOM 2124 C CB . PHE A 1 338 ? -56.311 -10.684 25.838 1.00 57.31 ? 311 PHE B CB 1 ATOM 2125 C CG . PHE A 1 338 ? -55.973 -10.220 27.212 1.00 59.93 ? 311 PHE B CG 1 ATOM 2126 C CD1 . PHE A 1 338 ? -54.641 -10.197 27.634 1.00 65.16 ? 311 PHE B CD1 1 ATOM 2127 C CD2 . PHE A 1 338 ? -56.965 -9.833 28.098 1.00 64.14 ? 311 PHE B CD2 1 ATOM 2128 C CE1 . PHE A 1 338 ? -54.295 -9.762 28.908 1.00 65.47 ? 311 PHE B CE1 1 ATOM 2129 C CE2 . PHE A 1 338 ? -56.632 -9.391 29.383 1.00 71.13 ? 311 PHE B CE2 1 ATOM 2130 C CZ . PHE A 1 338 ? -55.292 -9.356 29.784 1.00 73.45 ? 311 PHE B CZ 1 ATOM 2131 N N . HIS A 1 339 ? -58.504 -13.074 25.658 1.00 55.01 ? 312 HIS B N 1 ATOM 2132 C CA . HIS A 1 339 ? -59.708 -13.626 26.272 1.00 59.55 ? 312 HIS B CA 1 ATOM 2133 C C . HIS A 1 339 ? -59.495 -15.050 26.757 1.00 58.93 ? 312 HIS B C 1 ATOM 2134 O O . HIS A 1 339 ? -60.260 -15.555 27.549 1.00 63.61 ? 312 HIS B O 1 ATOM 2135 C CB . HIS A 1 339 ? -60.925 -13.510 25.327 1.00 60.60 ? 312 HIS B CB 1 ATOM 2136 C CG . HIS A 1 339 ? -60.783 -14.232 24.023 1.00 63.73 ? 312 HIS B CG 1 ATOM 2137 N ND1 . HIS A 1 339 ? -59.995 -13.770 22.990 1.00 68.41 ? 312 HIS B ND1 1 ATOM 2138 C CD2 . HIS A 1 339 ? -61.375 -15.359 23.567 1.00 68.28 ? 312 HIS B CD2 1 ATOM 2139 C CE1 . HIS A 1 339 ? -60.093 -14.596 21.962 1.00 71.20 ? 312 HIS B CE1 1 ATOM 2140 N NE2 . HIS A 1 339 ? -60.931 -15.565 22.284 1.00 68.19 ? 312 HIS B NE2 1 ATOM 2141 N N . VAL A 1 340 ? -58.457 -15.698 26.257 1.00 62.35 ? 313 VAL B N 1 ATOM 2142 C CA . VAL A 1 340 ? -58.072 -17.017 26.721 1.00 63.02 ? 313 VAL B CA 1 ATOM 2143 C C . VAL A 1 340 ? -56.904 -16.913 27.695 1.00 58.59 ? 313 VAL B C 1 ATOM 2144 O O . VAL A 1 340 ? -56.917 -17.486 28.770 1.00 52.41 ? 313 VAL B O 1 ATOM 2145 C CB . VAL A 1 340 ? -57.692 -17.890 25.518 1.00 69.74 ? 313 VAL B CB 1 ATOM 2146 C CG1 . VAL A 1 340 ? -57.045 -19.195 25.944 1.00 71.39 ? 313 VAL B CG1 1 ATOM 2147 C CG2 . VAL A 1 340 ? -58.931 -18.157 24.684 1.00 78.37 ? 313 VAL B CG2 1 ATOM 2148 N N . VAL A 1 341 ? -55.909 -16.130 27.319 1.00 61.27 ? 314 VAL B N 1 ATOM 2149 C CA . VAL A 1 341 ? -54.620 -16.186 27.949 1.00 60.04 ? 314 VAL B CA 1 ATOM 2150 C C . VAL A 1 341 ? -54.448 -15.049 28.966 1.00 55.15 ? 314 VAL B C 1 ATOM 2151 O O . VAL A 1 341 ? -53.479 -15.001 29.716 1.00 55.76 ? 314 VAL B O 1 ATOM 2152 C CB . VAL A 1 341 ? -53.548 -16.222 26.832 1.00 66.89 ? 314 VAL B CB 1 ATOM 2153 C CG1 . VAL A 1 341 ? -52.999 -14.836 26.530 1.00 70.61 ? 314 VAL B CG1 1 ATOM 2154 C CG2 . VAL A 1 341 ? -52.439 -17.193 27.180 1.00 76.87 ? 314 VAL B CG2 1 ATOM 2155 N N . GLY A 1 342 ? -55.409 -14.138 29.020 1.00 58.23 ? 315 GLY B N 1 ATOM 2156 C CA . GLY A 1 342 ? -55.366 -13.025 29.969 1.00 51.50 ? 315 GLY B CA 1 ATOM 2157 C C . GLY A 1 342 ? -55.311 -13.500 31.398 1.00 49.04 ? 315 GLY B C 1 ATOM 2158 O O . GLY A 1 342 ? -55.997 -14.448 31.787 1.00 49.20 ? 315 GLY B O 1 ATOM 2159 N N . GLY A 1 343 ? -54.475 -12.827 32.177 1.00 54.88 ? 316 GLY B N 1 ATOM 2160 C CA . GLY A 1 343 ? -54.334 -13.083 33.600 1.00 52.04 ? 316 GLY B CA 1 ATOM 2161 C C . GLY A 1 343 ? -53.402 -14.215 33.952 1.00 55.27 ? 316 GLY B C 1 ATOM 2162 O O . GLY A 1 343 ? -53.325 -14.563 35.128 1.00 60.43 ? 316 GLY B O 1 ATOM 2163 N N . THR A 1 344 ? -52.650 -14.769 32.984 1.00 54.07 ? 317 THR B N 1 ATOM 2164 C CA . THR A 1 344 ? -51.730 -15.850 33.335 1.00 51.25 ? 317 THR B CA 1 ATOM 2165 C C . THR A 1 344 ? -50.772 -15.365 34.396 1.00 51.20 ? 317 THR B C 1 ATOM 2166 O O . THR A 1 344 ? -50.482 -14.178 34.490 1.00 55.56 ? 317 THR B O 1 ATOM 2167 C CB . THR A 1 344 ? -50.949 -16.497 32.148 1.00 51.99 ? 317 THR B CB 1 ATOM 2168 O OG1 . THR A 1 344 ? -49.688 -15.861 31.932 1.00 55.14 ? 317 THR B OG1 1 ATOM 2169 C CG2 . THR A 1 344 ? -51.752 -16.497 30.887 1.00 49.73 ? 317 THR B CG2 1 ATOM 2170 N N . ILE A 1 345 ? -50.295 -16.287 35.212 1.00 52.62 ? 318 ILE B N 1 ATOM 2171 C CA . ILE A 1 345 ? -49.297 -15.973 36.209 1.00 51.45 ? 318 ILE B CA 1 ATOM 2172 C C . ILE A 1 345 ? -48.091 -16.793 35.837 1.00 50.21 ? 318 ILE B C 1 ATOM 2173 O O . ILE A 1 345 ? -48.226 -17.980 35.515 1.00 53.07 ? 318 ILE B O 1 ATOM 2174 C CB . ILE A 1 345 ? -49.805 -16.377 37.586 1.00 53.64 ? 318 ILE B CB 1 ATOM 2175 C CG1 . ILE A 1 345 ? -51.047 -15.544 37.920 1.00 61.93 ? 318 ILE B CG1 1 ATOM 2176 C CG2 . ILE A 1 345 ? -48.717 -16.181 38.627 1.00 52.46 ? 318 ILE B CG2 1 ATOM 2177 C CD1 . ILE A 1 345 ? -51.860 -16.095 39.084 1.00 70.08 ? 318 ILE B CD1 1 ATOM 2178 N N . GLY A 1 346 ? -46.916 -16.188 35.883 1.00 47.92 ? 319 GLY B N 1 ATOM 2179 C CA . GLY A 1 346 ? -45.712 -16.886 35.479 1.00 53.92 ? 319 GLY B CA 1 ATOM 2180 C C . GLY A 1 346 ? -44.435 -16.497 36.202 1.00 54.23 ? 319 GLY B C 1 ATOM 2181 O O . GLY A 1 346 ? -44.414 -15.561 36.975 1.00 50.36 ? 319 GLY B O 1 ATOM 2182 N N . PHE A 1 347 ? -43.363 -17.236 35.924 1.00 52.43 ? 320 PHE B N 1 ATOM 2183 C CA . PHE A 1 347 ? -42.066 -16.915 36.449 1.00 50.05 ? 320 PHE B CA 1 ATOM 2184 C C . PHE A 1 347 ? -41.249 -16.163 35.431 1.00 48.45 ? 320 PHE B C 1 ATOM 2185 O O . PHE A 1 347 ? -41.440 -16.333 34.247 1.00 51.66 ? 320 PHE B O 1 ATOM 2186 C CB . PHE A 1 347 ? -41.380 -18.179 36.910 1.00 51.09 ? 320 PHE B CB 1 ATOM 2187 C CG . PHE A 1 347 ? -42.146 -18.879 37.985 1.00 51.12 ? 320 PHE B CG 1 ATOM 2188 C CD1 . PHE A 1 347 ? -41.953 -18.556 39.318 1.00 54.41 ? 320 PHE B CD1 1 ATOM 2189 C CD2 . PHE A 1 347 ? -43.121 -19.780 37.661 1.00 51.43 ? 320 PHE B CD2 1 ATOM 2190 C CE1 . PHE A 1 347 ? -42.690 -19.166 40.316 1.00 58.28 ? 320 PHE B CE1 1 ATOM 2191 C CE2 . PHE A 1 347 ? -43.862 -20.394 38.646 1.00 55.97 ? 320 PHE B CE2 1 ATOM 2192 C CZ . PHE A 1 347 ? -43.653 -20.095 39.980 1.00 55.30 ? 320 PHE B CZ 1 ATOM 2193 N N . ALA A 1 348 ? -40.418 -15.258 35.930 1.00 48.06 ? 321 ALA B N 1 ATOM 2194 C CA . ALA A 1 348 ? -39.422 -14.567 35.163 1.00 51.57 ? 321 ALA B CA 1 ATOM 2195 C C . ALA A 1 348 ? -38.152 -14.572 35.995 1.00 54.71 ? 321 ALA B C 1 ATOM 2196 O O . ALA A 1 348 ? -38.221 -14.730 37.209 1.00 57.54 ? 321 ALA B O 1 ATOM 2197 C CB . ALA A 1 348 ? -39.863 -13.143 34.900 1.00 55.24 ? 321 ALA B CB 1 ATOM 2198 N N . LEU A 1 349 ? -36.993 -14.410 35.357 1.00 57.85 ? 322 LEU B N 1 ATOM 2199 C CA . LEU A 1 349 ? -35.733 -14.322 36.102 1.00 58.46 ? 322 LEU B CA 1 ATOM 2200 C C . LEU A 1 349 ? -35.643 -12.945 36.701 1.00 58.52 ? 322 LEU B C 1 ATOM 2201 O O . LEU A 1 349 ? -36.362 -12.048 36.283 1.00 60.71 ? 322 LEU B O 1 ATOM 2202 C CB . LEU A 1 349 ? -34.528 -14.574 35.210 1.00 59.28 ? 322 LEU B CB 1 ATOM 2203 C CG . LEU A 1 349 ? -34.185 -16.004 34.776 1.00 58.35 ? 322 LEU B CG 1 ATOM 2204 C CD1 . LEU A 1 349 ? -34.401 -17.005 35.887 1.00 60.10 ? 322 LEU B CD1 1 ATOM 2205 C CD2 . LEU A 1 349 ? -34.993 -16.413 33.581 1.00 60.93 ? 322 LEU B CD2 1 ATOM 2206 N N . LYS A 1 350 ? -34.786 -12.769 37.695 1.00 58.88 ? 323 LYS B N 1 ATOM 2207 C CA . LYS A 1 350 ? -34.633 -11.443 38.266 1.00 63.91 ? 323 LYS B CA 1 ATOM 2208 C C . LYS A 1 350 ? -34.098 -10.519 37.173 1.00 62.38 ? 323 LYS B C 1 ATOM 2209 O O . LYS A 1 350 ? -33.313 -10.931 36.339 1.00 66.85 ? 323 LYS B O 1 ATOM 2210 C CB . LYS A 1 350 ? -33.751 -11.433 39.539 1.00 67.30 ? 323 LYS B CB 1 ATOM 2211 C CG . LYS A 1 350 ? -34.455 -11.861 40.850 1.00 74.13 ? 323 LYS B CG 1 ATOM 2212 C CD . LYS A 1 350 ? -35.812 -11.181 41.111 1.00 77.17 ? 323 LYS B CD 1 ATOM 2213 C CE . LYS A 1 350 ? -36.039 -10.700 42.551 1.00 82.73 ? 323 LYS B CE 1 ATOM 2214 N NZ . LYS A 1 350 ? -35.859 -11.689 43.664 1.00 86.47 ? 323 LYS B NZ 1 ATOM 2215 N N . ALA A 1 351 ? -34.591 -9.285 37.144 1.00 69.91 ? 324 ALA B N 1 ATOM 2216 C CA . ALA A 1 351 ? -34.160 -8.286 36.159 1.00 64.48 ? 324 ALA B CA 1 ATOM 2217 C C . ALA A 1 351 ? -32.762 -7.841 36.499 1.00 57.72 ? 324 ALA B C 1 ATOM 2218 O O . ALA A 1 351 ? -32.365 -7.914 37.650 1.00 59.32 ? 324 ALA B O 1 ATOM 2219 C CB . ALA A 1 351 ? -35.103 -7.086 36.179 1.00 64.84 ? 324 ALA B CB 1 ATOM 2220 N N . GLY A 1 352 ? -32.016 -7.394 35.498 1.00 54.73 ? 325 GLY B N 1 ATOM 2221 C CA . GLY A 1 352 ? -30.665 -6.883 35.692 1.00 54.40 ? 325 GLY B CA 1 ATOM 2222 C C . GLY A 1 352 ? -30.530 -5.620 34.889 1.00 61.34 ? 325 GLY B C 1 ATOM 2223 O O . GLY A 1 352 ? -31.419 -5.308 34.092 1.00 63.07 ? 325 GLY B O 1 ATOM 2224 N N . GLN A 1 353 ? -29.430 -4.891 35.093 1.00 69.17 ? 326 GLN B N 1 ATOM 2225 C CA . GLN A 1 353 ? -29.227 -3.582 34.468 1.00 67.77 ? 326 GLN B CA 1 ATOM 2226 C C . GLN A 1 353 ? -27.961 -3.568 33.635 1.00 69.29 ? 326 GLN B C 1 ATOM 2227 O O . GLN A 1 353 ? -26.917 -4.024 34.070 1.00 73.17 ? 326 GLN B O 1 ATOM 2228 C CB . GLN A 1 353 ? -29.162 -2.471 35.516 1.00 78.31 ? 326 GLN B CB 1 ATOM 2229 C CG . GLN A 1 353 ? -30.520 -1.955 35.983 1.00 89.19 ? 326 GLN B CG 1 ATOM 2230 C CD . GLN A 1 353 ? -30.392 -0.793 36.964 1.00 106.17 ? 326 GLN B CD 1 ATOM 2231 O OE1 . GLN A 1 353 ? -29.488 0.045 36.852 1.00 103.20 ? 326 GLN B OE1 1 ATOM 2232 N NE2 . GLN A 1 353 ? -31.306 -0.732 37.930 1.00 115.18 ? 326 GLN B NE2 1 ATOM 2233 N N . ILE A 1 354 ? -28.064 -3.038 32.425 1.00 71.43 ? 327 ILE B N 1 ATOM 2234 C CA . ILE A 1 354 ? -26.916 -2.849 31.569 1.00 67.36 ? 327 ILE B CA 1 ATOM 2235 C C . ILE A 1 354 ? -26.892 -1.391 31.082 1.00 69.87 ? 327 ILE B C 1 ATOM 2236 O O . ILE A 1 354 ? -27.402 -1.070 30.005 1.00 68.33 ? 327 ILE B O 1 ATOM 2237 C CB . ILE A 1 354 ? -26.967 -3.796 30.376 1.00 66.74 ? 327 ILE B CB 1 ATOM 2238 C CG1 . ILE A 1 354 ? -27.419 -5.188 30.812 1.00 71.76 ? 327 ILE B CG1 1 ATOM 2239 C CG2 . ILE A 1 354 ? -25.604 -3.850 29.718 1.00 68.99 ? 327 ILE B CG2 1 ATOM 2240 C CD1 . ILE A 1 354 ? -27.430 -6.213 29.689 1.00 74.17 ? 327 ILE B CD1 1 ATOM 2241 N N . PRO A 1 355 ? -26.301 -0.493 31.882 1.00 72.64 ? 328 PRO B N 1 ATOM 2242 C CA . PRO A 1 355 ? -26.165 0.894 31.437 1.00 70.41 ? 328 PRO B CA 1 ATOM 2243 C C . PRO A 1 355 ? -25.470 0.957 30.102 1.00 68.50 ? 328 PRO B C 1 ATOM 2244 O O . PRO A 1 355 ? -24.415 0.324 29.923 1.00 73.51 ? 328 PRO B O 1 ATOM 2245 C CB . PRO A 1 355 ? -25.280 1.518 32.506 1.00 74.05 ? 328 PRO B CB 1 ATOM 2246 C CG . PRO A 1 355 ? -25.491 0.653 33.711 1.00 76.40 ? 328 PRO B CG 1 ATOM 2247 C CD . PRO A 1 355 ? -25.632 -0.728 33.171 1.00 69.30 ? 328 PRO B CD 1 ATOM 2248 N N . GLY A 1 356 ? -26.085 1.671 29.164 1.00 65.14 ? 329 GLY B N 1 ATOM 2249 C CA . GLY A 1 356 ? -25.529 1.835 27.817 1.00 65.38 ? 329 GLY B CA 1 ATOM 2250 C C . GLY A 1 356 ? -26.163 0.933 26.774 1.00 68.99 ? 329 GLY B C 1 ATOM 2251 O O . GLY A 1 356 ? -25.998 1.158 25.586 1.00 74.99 ? 329 GLY B O 1 ATOM 2252 N N . PHE A 1 357 ? -26.892 -0.097 27.201 1.00 70.31 ? 330 PHE B N 1 ATOM 2253 C CA . PHE A 1 357 ? -27.299 -1.149 26.275 1.00 60.84 ? 330 PHE B CA 1 ATOM 2254 C C . PHE A 1 357 ? -28.361 -0.636 25.305 1.00 59.69 ? 330 PHE B C 1 ATOM 2255 O O . PHE A 1 357 ? -28.150 -0.642 24.107 1.00 59.44 ? 330 PHE B O 1 ATOM 2256 C CB . PHE A 1 357 ? -27.777 -2.389 27.030 1.00 55.87 ? 330 PHE B CB 1 ATOM 2257 C CG . PHE A 1 357 ? -28.093 -3.558 26.139 1.00 51.83 ? 330 PHE B CG 1 ATOM 2258 C CD1 . PHE A 1 357 ? -27.173 -4.021 25.214 1.00 49.22 ? 330 PHE B CD1 1 ATOM 2259 C CD2 . PHE A 1 357 ? -29.312 -4.196 26.229 1.00 53.70 ? 330 PHE B CD2 1 ATOM 2260 C CE1 . PHE A 1 357 ? -27.458 -5.098 24.386 1.00 47.13 ? 330 PHE B CE1 1 ATOM 2261 C CE2 . PHE A 1 357 ? -29.602 -5.272 25.404 1.00 53.94 ? 330 PHE B CE2 1 ATOM 2262 C CZ . PHE A 1 357 ? -28.666 -5.730 24.494 1.00 50.62 ? 330 PHE B CZ 1 ATOM 2263 N N . ARG A 1 358 ? -29.482 -0.164 25.829 1.00 59.99 ? 331 ARG B N 1 ATOM 2264 C CA . ARG A 1 358 ? -30.494 0.485 25.000 1.00 60.90 ? 331 ARG B CA 1 ATOM 2265 C C . ARG A 1 358 ? -29.950 1.466 23.932 1.00 63.30 ? 331 ARG B C 1 ATOM 2266 O O . ARG A 1 358 ? -30.451 1.492 22.823 1.00 54.61 ? 331 ARG B O 1 ATOM 2267 C CB . ARG A 1 358 ? -31.485 1.222 25.869 1.00 60.47 ? 331 ARG B CB 1 ATOM 2268 C CG . ARG A 1 358 ? -32.754 1.526 25.125 1.00 65.21 ? 331 ARG B CG 1 ATOM 2269 C CD . ARG A 1 358 ? -33.882 1.939 26.045 1.00 67.72 ? 331 ARG B CD 1 ATOM 2270 N NE . ARG A 1 358 ? -35.097 1.388 25.486 1.00 76.21 ? 331 ARG B NE 1 ATOM 2271 C CZ . ARG A 1 358 ? -35.880 0.476 26.060 1.00 85.07 ? 331 ARG B CZ 1 ATOM 2272 N NH1 . ARG A 1 358 ? -35.664 0.010 27.290 1.00 78.76 ? 331 ARG B NH1 1 ATOM 2273 N NH2 . ARG A 1 358 ? -36.939 0.052 25.391 1.00 96.88 ? 331 ARG B NH2 1 ATOM 2274 N N . GLU A 1 359 ? -28.928 2.255 24.259 1.00 68.73 ? 332 GLU B N 1 ATOM 2275 C CA . GLU A 1 359 ? -28.300 3.138 23.262 1.00 68.53 ? 332 GLU B CA 1 ATOM 2276 C C . GLU A 1 359 ? -27.593 2.328 22.187 1.00 69.14 ? 332 GLU B C 1 ATOM 2277 O O . GLU A 1 359 ? -27.643 2.674 21.006 1.00 83.73 ? 332 GLU B O 1 ATOM 2278 C CB . GLU A 1 359 ? -27.309 4.119 23.903 1.00 67.32 ? 332 GLU B CB 1 ATOM 2279 N N . PHE A 1 360 ? -26.934 1.253 22.595 1.00 63.05 ? 333 PHE B N 1 ATOM 2280 C CA . PHE A 1 360 ? -26.227 0.377 21.661 1.00 58.00 ? 333 PHE B CA 1 ATOM 2281 C C . PHE A 1 360 ? -27.173 -0.301 20.641 1.00 59.81 ? 333 PHE B C 1 ATOM 2282 O O . PHE A 1 360 ? -26.859 -0.443 19.443 1.00 59.13 ? 333 PHE B O 1 ATOM 2283 C CB . PHE A 1 360 ? -25.474 -0.673 22.466 1.00 51.90 ? 333 PHE B CB 1 ATOM 2284 C CG . PHE A 1 360 ? -24.746 -1.651 21.628 1.00 53.79 ? 333 PHE B CG 1 ATOM 2285 C CD1 . PHE A 1 360 ? -23.508 -1.319 21.063 1.00 53.53 ? 333 PHE B CD1 1 ATOM 2286 C CD2 . PHE A 1 360 ? -25.295 -2.919 21.380 1.00 50.69 ? 333 PHE B CD2 1 ATOM 2287 C CE1 . PHE A 1 360 ? -22.814 -2.242 20.291 1.00 51.68 ? 333 PHE B CE1 1 ATOM 2288 C CE2 . PHE A 1 360 ? -24.619 -3.836 20.594 1.00 49.15 ? 333 PHE B CE2 1 ATOM 2289 C CZ . PHE A 1 360 ? -23.375 -3.502 20.057 1.00 52.27 ? 333 PHE B CZ 1 ATOM 2290 N N . LEU A 1 361 ? -28.329 -0.716 21.140 1.00 63.19 ? 334 LEU B N 1 ATOM 2291 C CA . LEU A 1 361 ? -29.351 -1.380 20.344 1.00 68.70 ? 334 LEU B CA 1 ATOM 2292 C C . LEU A 1 361 ? -29.956 -0.450 19.301 1.00 75.97 ? 334 LEU B C 1 ATOM 2293 O O . LEU A 1 361 ? -30.553 -0.924 18.351 1.00 76.77 ? 334 LEU B O 1 ATOM 2294 C CB . LEU A 1 361 ? -30.499 -1.866 21.249 1.00 66.90 ? 334 LEU B CB 1 ATOM 2295 C CG . LEU A 1 361 ? -30.630 -3.297 21.779 1.00 66.29 ? 334 LEU B CG 1 ATOM 2296 C CD1 . LEU A 1 361 ? -29.361 -4.137 21.685 1.00 62.58 ? 334 LEU B CD1 1 ATOM 2297 C CD2 . LEU A 1 361 ? -31.186 -3.258 23.200 1.00 66.60 ? 334 LEU B CD2 1 ATOM 2298 N N . LYS A 1 362 ? -29.862 0.865 19.511 1.00 75.40 ? 335 LYS B N 1 ATOM 2299 C CA . LYS A 1 362 ? -30.407 1.828 18.561 1.00 69.30 ? 335 LYS B CA 1 ATOM 2300 C C . LYS A 1 362 ? -29.412 2.270 17.506 1.00 72.38 ? 335 LYS B C 1 ATOM 2301 O O . LYS A 1 362 ? -29.778 3.006 16.617 1.00 82.99 ? 335 LYS B O 1 ATOM 2302 C CB . LYS A 1 362 ? -30.956 3.034 19.287 1.00 68.99 ? 335 LYS B CB 1 ATOM 2303 C CG . LYS A 1 362 ? -32.178 2.698 20.116 1.00 71.05 ? 335 LYS B CG 1 ATOM 2304 C CD . LYS A 1 362 ? -32.658 3.903 20.911 1.00 73.26 ? 335 LYS B CD 1 ATOM 2305 C CE . LYS A 1 362 ? -33.964 3.609 21.633 1.00 76.58 ? 335 LYS B CE 1 ATOM 2306 N NZ . LYS A 1 362 ? -34.305 4.695 22.590 1.00 82.62 ? 335 LYS B NZ 1 ATOM 2307 N N . LYS A 1 363 ? -28.178 1.802 17.578 1.00 76.22 ? 336 LYS B N 1 ATOM 2308 C CA . LYS A 1 363 ? -27.185 2.114 16.566 1.00 87.65 ? 336 LYS B CA 1 ATOM 2309 C C . LYS A 1 363 ? -27.083 1.038 15.480 1.00 88.35 ? 336 LYS B C 1 ATOM 2310 O O . LYS A 1 363 ? -26.142 1.080 14.659 1.00 76.71 ? 336 LYS B O 1 ATOM 2311 C CB . LYS A 1 363 ? -25.806 2.292 17.221 1.00 100.66 ? 336 LYS B CB 1 ATOM 2312 C CG . LYS A 1 363 ? -25.664 3.521 18.115 1.00 103.14 ? 336 LYS B CG 1 ATOM 2313 C CD . LYS A 1 363 ? -24.335 3.542 18.872 1.00 110.99 ? 336 LYS B CD 1 ATOM 2314 C CE . LYS A 1 363 ? -23.120 3.255 17.990 1.00 112.30 ? 336 LYS B CE 1 ATOM 2315 N NZ . LYS A 1 363 ? -21.867 3.230 18.793 1.00 115.34 ? 336 LYS B NZ 1 ATOM 2316 N N . VAL A 1 364 ? -28.016 0.073 15.484 1.00 87.62 ? 337 VAL B N 1 ATOM 2317 C CA . VAL A 1 364 ? -27.993 -1.033 14.499 1.00 79.76 ? 337 VAL B CA 1 ATOM 2318 C C . VAL A 1 364 ? -28.073 -0.429 13.133 1.00 77.23 ? 337 VAL B C 1 ATOM 2319 O O . VAL A 1 364 ? -28.876 0.483 12.920 1.00 85.44 ? 337 VAL B O 1 ATOM 2320 C CB . VAL A 1 364 ? -29.228 -1.975 14.507 1.00 78.03 ? 337 VAL B CB 1 ATOM 2321 C CG1 . VAL A 1 364 ? -28.804 -3.379 14.100 1.00 81.71 ? 337 VAL B CG1 1 ATOM 2322 C CG2 . VAL A 1 364 ? -29.949 -2.000 15.826 1.00 74.02 ? 337 VAL B CG2 1 ATOM 2323 N N . HIS A 1 365 ? -27.297 -0.944 12.192 1.00 74.89 ? 338 HIS B N 1 ATOM 2324 C CA . HIS A 1 365 ? -27.430 -0.468 10.830 1.00 77.16 ? 338 HIS B CA 1 ATOM 2325 C C . HIS A 1 365 ? -26.943 -1.482 9.844 1.00 71.21 ? 338 HIS B C 1 ATOM 2326 O O . HIS A 1 365 ? -25.882 -2.030 10.035 1.00 70.44 ? 338 HIS B O 1 ATOM 2327 C CB . HIS A 1 365 ? -26.629 0.812 10.620 1.00 86.82 ? 338 HIS B CB 1 ATOM 2328 C CG . HIS A 1 365 ? -27.206 1.696 9.564 1.00 91.93 ? 338 HIS B CG 1 ATOM 2329 N ND1 . HIS A 1 365 ? -28.358 2.421 9.772 1.00 89.38 ? 338 HIS B ND1 1 ATOM 2330 C CD2 . HIS A 1 365 ? -26.813 1.961 8.296 1.00 82.38 ? 338 HIS B CD2 1 ATOM 2331 C CE1 . HIS A 1 365 ? -28.643 3.104 8.681 1.00 87.93 ? 338 HIS B CE1 1 ATOM 2332 N NE2 . HIS A 1 365 ? -27.723 2.840 7.771 1.00 86.50 ? 338 HIS B NE2 1 ATOM 2333 N N . PRO A 1 366 ? -27.702 -1.707 8.764 1.00 69.08 ? 339 PRO B N 1 ATOM 2334 C CA . PRO A 1 366 ? -27.246 -2.629 7.726 1.00 72.39 ? 339 PRO B CA 1 ATOM 2335 C C . PRO A 1 366 ? -25.918 -2.249 7.076 1.00 74.02 ? 339 PRO B C 1 ATOM 2336 O O . PRO A 1 366 ? -25.240 -3.109 6.567 1.00 71.76 ? 339 PRO B O 1 ATOM 2337 C CB . PRO A 1 366 ? -28.361 -2.589 6.683 1.00 73.31 ? 339 PRO B CB 1 ATOM 2338 C CG . PRO A 1 366 ? -29.382 -1.624 7.174 1.00 73.85 ? 339 PRO B CG 1 ATOM 2339 C CD . PRO A 1 366 ? -29.104 -1.301 8.593 1.00 70.00 ? 339 PRO B CD 1 ATOM 2340 N N . ARG A 1 367 ? -25.587 -0.964 7.070 1.00 85.33 ? 340 ARG B N 1 ATOM 2341 C CA . ARG A 1 367 ? -24.331 -0.474 6.506 1.00 91.19 ? 340 ARG B CA 1 ATOM 2342 C C . ARG A 1 367 ? -23.262 -0.381 7.593 1.00 90.09 ? 340 ARG B C 1 ATOM 2343 O O . ARG A 1 367 ? -22.292 -1.128 7.562 1.00 91.48 ? 340 ARG B O 1 ATOM 2344 C CB . ARG A 1 367 ? -24.534 0.900 5.834 1.00 98.31 ? 340 ARG B CB 1 ATOM 2345 N N . LYS A 1 368 ? -23.456 0.528 8.551 1.00 92.61 ? 341 LYS B N 1 ATOM 2346 C CA . LYS A 1 368 ? -22.516 0.765 9.671 1.00 94.36 ? 341 LYS B CA 1 ATOM 2347 C C . LYS A 1 368 ? -22.003 -0.502 10.400 1.00 92.65 ? 341 LYS B C 1 ATOM 2348 O O . LYS A 1 368 ? -20.813 -0.591 10.710 1.00 95.59 ? 341 LYS B O 1 ATOM 2349 C CB . LYS A 1 368 ? -23.149 1.725 10.697 1.00 90.62 ? 341 LYS B CB 1 ATOM 2350 N N . SER A 1 369 ? -22.887 -1.471 10.658 1.00 88.11 ? 342 SER B N 1 ATOM 2351 C CA . SER A 1 369 ? -22.511 -2.748 11.324 1.00 84.11 ? 342 SER B CA 1 ATOM 2352 C C . SER A 1 369 ? -21.836 -3.803 10.392 1.00 82.95 ? 342 SER B C 1 ATOM 2353 O O . SER A 1 369 ? -22.482 -4.692 9.827 1.00 74.88 ? 342 SER B O 1 ATOM 2354 C CB . SER A 1 369 ? -23.732 -3.348 12.037 1.00 80.87 ? 342 SER B CB 1 ATOM 2355 O OG . SER A 1 369 ? -24.484 -2.351 12.728 1.00 81.62 ? 342 SER B OG 1 ATOM 2356 N N . VAL A 1 370 ? -20.520 -3.682 10.247 1.00 87.27 ? 343 VAL B N 1 ATOM 2357 C CA . VAL A 1 370 ? -19.746 -4.579 9.397 1.00 90.63 ? 343 VAL B CA 1 ATOM 2358 C C . VAL A 1 370 ? -19.708 -6.008 9.963 1.00 86.18 ? 343 VAL B C 1 ATOM 2359 O O . VAL A 1 370 ? -19.961 -6.972 9.251 1.00 85.05 ? 343 VAL B O 1 ATOM 2360 C CB . VAL A 1 370 ? -18.297 -4.059 9.208 1.00 82.43 ? 343 VAL B CB 1 ATOM 2361 N N . HIS A 1 371 ? -19.412 -6.135 11.250 1.00 80.61 ? 344 HIS B N 1 ATOM 2362 C CA . HIS A 1 371 ? -19.113 -7.437 11.847 1.00 80.06 ? 344 HIS B CA 1 ATOM 2363 C C . HIS A 1 371 ? -20.381 -8.295 12.091 1.00 80.50 ? 344 HIS B C 1 ATOM 2364 O O . HIS A 1 371 ? -20.356 -9.520 11.912 1.00 71.18 ? 344 HIS B O 1 ATOM 2365 C CB . HIS A 1 371 ? -18.305 -7.237 13.135 1.00 79.09 ? 344 HIS B CB 1 ATOM 2366 C CG . HIS A 1 371 ? -17.053 -6.428 12.938 1.00 86.71 ? 344 HIS B CG 1 ATOM 2367 N ND1 . HIS A 1 371 ? -15.959 -6.901 12.236 1.00 87.92 ? 344 HIS B ND1 1 ATOM 2368 C CD2 . HIS A 1 371 ? -16.729 -5.170 13.337 1.00 82.60 ? 344 HIS B CD2 1 ATOM 2369 C CE1 . HIS A 1 371 ? -15.017 -5.971 12.214 1.00 82.46 ? 344 HIS B CE1 1 ATOM 2370 N NE2 . HIS A 1 371 ? -15.457 -4.914 12.880 1.00 78.36 ? 344 HIS B NE2 1 ATOM 2371 N N . ASN A 1 372 ? -21.491 -7.640 12.437 1.00 70.43 ? 345 ASN B N 1 ATOM 2372 C CA . ASN A 1 372 ? -22.779 -8.315 12.621 1.00 61.39 ? 345 ASN B CA 1 ATOM 2373 C C . ASN A 1 372 ? -23.613 -8.604 11.354 1.00 61.22 ? 345 ASN B C 1 ATOM 2374 O O . ASN A 1 372 ? -24.540 -7.869 11.032 1.00 66.71 ? 345 ASN B O 1 ATOM 2375 C CB . ASN A 1 372 ? -23.617 -7.488 13.590 1.00 59.47 ? 345 ASN B CB 1 ATOM 2376 C CG . ASN A 1 372 ? -24.820 -8.243 14.096 1.00 56.68 ? 345 ASN B CG 1 ATOM 2377 O OD1 . ASN A 1 372 ? -25.147 -9.319 13.586 1.00 48.98 ? 345 ASN B OD1 1 ATOM 2378 N ND2 . ASN A 1 372 ? -25.497 -7.681 15.102 1.00 56.67 ? 345 ASN B ND2 1 ATOM 2379 N N . GLY A 1 373 ? -23.338 -9.716 10.680 1.00 61.78 ? 346 GLY B N 1 ATOM 2380 C CA . GLY A 1 373 ? -24.085 -10.119 9.474 1.00 55.80 ? 346 GLY B CA 1 ATOM 2381 C C . GLY A 1 373 ? -25.518 -10.598 9.648 1.00 62.85 ? 346 GLY B C 1 ATOM 2382 O O . GLY A 1 373 ? -26.101 -11.156 8.711 1.00 73.25 ? 346 GLY B O 1 ATOM 2383 N N . PHE A 1 374 ? -26.089 -10.404 10.839 1.00 61.21 ? 347 PHE B N 1 ATOM 2384 C CA . PHE A 1 374 ? -27.503 -10.649 11.091 1.00 54.28 ? 347 PHE B CA 1 ATOM 2385 C C . PHE A 1 374 ? -28.286 -9.354 11.001 1.00 53.66 ? 347 PHE B C 1 ATOM 2386 O O . PHE A 1 374 ? -29.509 -9.373 11.036 1.00 52.99 ? 347 PHE B O 1 ATOM 2387 C CB . PHE A 1 374 ? -27.696 -11.259 12.480 1.00 54.55 ? 347 PHE B CB 1 ATOM 2388 C CG . PHE A 1 374 ? -27.190 -12.667 12.597 1.00 55.91 ? 347 PHE B CG 1 ATOM 2389 C CD1 . PHE A 1 374 ? -27.812 -13.697 11.924 1.00 55.61 ? 347 PHE B CD1 1 ATOM 2390 C CD2 . PHE A 1 374 ? -26.086 -12.967 13.387 1.00 58.62 ? 347 PHE B CD2 1 ATOM 2391 C CE1 . PHE A 1 374 ? -27.344 -14.998 12.018 1.00 56.49 ? 347 PHE B CE1 1 ATOM 2392 C CE2 . PHE A 1 374 ? -25.612 -14.263 13.484 1.00 56.48 ? 347 PHE B CE2 1 ATOM 2393 C CZ . PHE A 1 374 ? -26.246 -15.282 12.802 1.00 57.12 ? 347 PHE B CZ 1 ATOM 2394 N N . ALA A 1 375 ? -27.565 -8.236 10.905 1.00 57.61 ? 348 ALA B N 1 ATOM 2395 C CA . ALA A 1 375 ? -28.150 -6.889 10.905 1.00 60.75 ? 348 ALA B CA 1 ATOM 2396 C C . ALA A 1 375 ? -28.947 -6.547 9.637 1.00 61.30 ? 348 ALA B C 1 ATOM 2397 O O . ALA A 1 375 ? -29.903 -5.775 9.699 1.00 62.43 ? 348 ALA B O 1 ATOM 2398 C CB . ALA A 1 375 ? -27.046 -5.870 11.094 1.00 61.31 ? 348 ALA B CB 1 ATOM 2399 N N . LYS A 1 376 ? -28.518 -7.093 8.500 1.00 58.74 ? 349 LYS B N 1 ATOM 2400 C CA . LYS A 1 376 ? -29.259 -6.966 7.267 1.00 59.78 ? 349 LYS B CA 1 ATOM 2401 C C . LYS A 1 376 ? -30.682 -7.511 7.510 1.00 58.05 ? 349 LYS B C 1 ATOM 2402 O O . LYS A 1 376 ? -31.607 -6.707 7.640 1.00 55.72 ? 349 LYS B O 1 ATOM 2403 C CB . LYS A 1 376 ? -28.523 -7.667 6.099 1.00 56.27 ? 349 LYS B CB 1 ATOM 2404 N N . GLU A 1 377 ? -30.854 -8.839 7.635 1.00 57.04 ? 350 GLU B N 1 ATOM 2405 C CA . GLU A 1 377 ? -32.205 -9.444 7.815 1.00 52.15 ? 350 GLU B CA 1 ATOM 2406 C C . GLU A 1 377 ? -32.982 -8.854 8.991 1.00 49.31 ? 350 GLU B C 1 ATOM 2407 O O . GLU A 1 377 ? -34.204 -8.799 8.983 1.00 56.37 ? 350 GLU B O 1 ATOM 2408 C CB . GLU A 1 377 ? -32.147 -10.962 7.980 1.00 55.35 ? 350 GLU B CB 1 ATOM 2409 C CG . GLU A 1 377 ? -33.540 -11.611 8.052 1.00 63.77 ? 350 GLU B CG 1 ATOM 2410 C CD . GLU A 1 377 ? -33.556 -13.127 8.302 1.00 77.14 ? 350 GLU B CD 1 ATOM 2411 O OE1 . GLU A 1 377 ? -32.572 -13.653 8.876 1.00 92.25 ? 350 GLU B OE1 1 ATOM 2412 O OE2 . GLU A 1 377 ? -34.573 -13.795 7.952 1.00 80.39 ? 350 GLU B OE2 1 ATOM 2413 N N . PHE A 1 378 ? -32.287 -8.417 10.019 1.00 50.16 ? 351 PHE B N 1 ATOM 2414 C CA . PHE A 1 378 ? -32.956 -7.696 11.074 1.00 51.48 ? 351 PHE B CA 1 ATOM 2415 C C . PHE A 1 378 ? -33.723 -6.519 10.470 1.00 54.98 ? 351 PHE B C 1 ATOM 2416 O O . PHE A 1 378 ? -34.906 -6.352 10.736 1.00 61.64 ? 351 PHE B O 1 ATOM 2417 C CB . PHE A 1 378 ? -31.961 -7.209 12.130 1.00 49.32 ? 351 PHE B CB 1 ATOM 2418 C CG . PHE A 1 378 ? -32.546 -6.194 13.063 1.00 53.25 ? 351 PHE B CG 1 ATOM 2419 C CD1 . PHE A 1 378 ? -33.490 -6.570 13.996 1.00 54.04 ? 351 PHE B CD1 1 ATOM 2420 C CD2 . PHE A 1 378 ? -32.204 -4.863 12.963 1.00 51.05 ? 351 PHE B CD2 1 ATOM 2421 C CE1 . PHE A 1 378 ? -34.059 -5.633 14.839 1.00 58.76 ? 351 PHE B CE1 1 ATOM 2422 C CE2 . PHE A 1 378 ? -32.773 -3.931 13.800 1.00 54.52 ? 351 PHE B CE2 1 ATOM 2423 C CZ . PHE A 1 378 ? -33.712 -4.311 14.732 1.00 56.15 ? 351 PHE B CZ 1 ATOM 2424 N N . TRP A 1 379 ? -33.035 -5.716 9.667 1.00 56.55 ? 352 TRP B N 1 ATOM 2425 C CA . TRP A 1 379 ? -33.592 -4.493 9.095 1.00 66.38 ? 352 TRP B CA 1 ATOM 2426 C C . TRP A 1 379 ? -34.821 -4.764 8.243 1.00 63.15 ? 352 TRP B C 1 ATOM 2427 O O . TRP A 1 379 ? -35.915 -4.227 8.476 1.00 56.13 ? 352 TRP B O 1 ATOM 2428 C CB . TRP A 1 379 ? -32.536 -3.808 8.220 1.00 71.29 ? 352 TRP B CB 1 ATOM 2429 C CG . TRP A 1 379 ? -32.801 -2.388 8.063 1.00 78.21 ? 352 TRP B CG 1 ATOM 2430 C CD1 . TRP A 1 379 ? -33.296 -1.772 6.979 1.00 77.38 ? 352 TRP B CD1 1 ATOM 2431 C CD2 . TRP A 1 379 ? -32.601 -1.377 9.058 1.00 81.01 ? 352 TRP B CD2 1 ATOM 2432 N NE1 . TRP A 1 379 ? -33.415 -0.417 7.221 1.00 84.87 ? 352 TRP B NE1 1 ATOM 2433 C CE2 . TRP A 1 379 ? -32.986 -0.154 8.492 1.00 79.22 ? 352 TRP B CE2 1 ATOM 2434 C CE3 . TRP A 1 379 ? -32.129 -1.392 10.369 1.00 71.37 ? 352 TRP B CE3 1 ATOM 2435 C CZ2 . TRP A 1 379 ? -32.912 1.041 9.187 1.00 79.24 ? 352 TRP B CZ2 1 ATOM 2436 C CZ3 . TRP A 1 379 ? -32.053 -0.208 11.056 1.00 73.67 ? 352 TRP B CZ3 1 ATOM 2437 C CH2 . TRP A 1 379 ? -32.443 0.991 10.472 1.00 75.87 ? 352 TRP B CH2 1 ATOM 2438 N N . GLU A 1 380 ? -34.597 -5.629 7.261 1.00 60.85 ? 353 GLU B N 1 ATOM 2439 C CA . GLU A 1 380 ? -35.613 -6.087 6.359 1.00 61.75 ? 353 GLU B CA 1 ATOM 2440 C C . GLU A 1 380 ? -36.840 -6.564 7.135 1.00 65.52 ? 353 GLU B C 1 ATOM 2441 O O . GLU A 1 380 ? -37.957 -6.205 6.787 1.00 78.13 ? 353 GLU B O 1 ATOM 2442 C CB . GLU A 1 380 ? -35.056 -7.200 5.449 1.00 65.93 ? 353 GLU B CB 1 ATOM 2443 C CG . GLU A 1 380 ? -34.015 -6.750 4.400 1.00 72.39 ? 353 GLU B CG 1 ATOM 2444 C CD . GLU A 1 380 ? -33.460 -7.889 3.519 1.00 77.01 ? 353 GLU B CD 1 ATOM 2445 O OE1 . GLU A 1 380 ? -33.640 -9.071 3.872 1.00 87.12 ? 353 GLU B OE1 1 ATOM 2446 O OE2 . GLU A 1 380 ? -32.827 -7.619 2.467 1.00 79.15 ? 353 GLU B OE2 1 ATOM 2447 N N . GLU A 1 381 ? -36.657 -7.353 8.191 1.00 60.40 ? 354 GLU B N 1 ATOM 2448 C CA . GLU A 1 381 ? -37.808 -7.845 8.922 1.00 57.71 ? 354 GLU B CA 1 ATOM 2449 C C . GLU A 1 381 ? -38.526 -6.720 9.643 1.00 60.33 ? 354 GLU B C 1 ATOM 2450 O O . GLU A 1 381 ? -39.744 -6.684 9.728 1.00 64.16 ? 354 GLU B O 1 ATOM 2451 C CB . GLU A 1 381 ? -37.392 -8.924 9.900 1.00 59.48 ? 354 GLU B CB 1 ATOM 2452 C CG . GLU A 1 381 ? -37.037 -10.216 9.218 1.00 68.08 ? 354 GLU B CG 1 ATOM 2453 C CD . GLU A 1 381 ? -38.229 -10.806 8.500 1.00 75.65 ? 354 GLU B CD 1 ATOM 2454 O OE1 . GLU A 1 381 ? -38.167 -10.909 7.254 1.00 79.49 ? 354 GLU B OE1 1 ATOM 2455 O OE2 . GLU A 1 381 ? -39.234 -11.127 9.180 1.00 72.47 ? 354 GLU B OE2 1 ATOM 2456 N N . THR A 1 382 ? -37.757 -5.792 10.172 1.00 69.15 ? 355 THR B N 1 ATOM 2457 C CA . THR A 1 382 ? -38.311 -4.739 10.991 1.00 72.53 ? 355 THR B CA 1 ATOM 2458 C C . THR A 1 382 ? -39.156 -3.822 10.100 1.00 75.78 ? 355 THR B C 1 ATOM 2459 O O . THR A 1 382 ? -40.296 -3.482 10.418 1.00 66.14 ? 355 THR B O 1 ATOM 2460 C CB . THR A 1 382 ? -37.177 -3.929 11.661 1.00 72.85 ? 355 THR B CB 1 ATOM 2461 O OG1 . THR A 1 382 ? -36.299 -4.811 12.391 1.00 64.01 ? 355 THR B OG1 1 ATOM 2462 C CG2 . THR A 1 382 ? -37.761 -2.857 12.589 1.00 68.58 ? 355 THR B CG2 1 ATOM 2463 N N . PHE A 1 383 ? -38.582 -3.449 8.965 1.00 79.66 ? 356 PHE B N 1 ATOM 2464 C CA . PHE A 1 383 ? -39.179 -2.451 8.102 1.00 80.42 ? 356 PHE B CA 1 ATOM 2465 C C . PHE A 1 383 ? -39.854 -3.040 6.870 1.00 82.53 ? 356 PHE B C 1 ATOM 2466 O O . PHE A 1 383 ? -40.295 -2.311 5.986 1.00 74.75 ? 356 PHE B O 1 ATOM 2467 C CB . PHE A 1 383 ? -38.099 -1.475 7.704 1.00 75.19 ? 356 PHE B CB 1 ATOM 2468 C CG . PHE A 1 383 ? -37.550 -0.718 8.860 1.00 75.31 ? 356 PHE B CG 1 ATOM 2469 C CD1 . PHE A 1 383 ? -38.378 0.121 9.611 1.00 69.63 ? 356 PHE B CD1 1 ATOM 2470 C CD2 . PHE A 1 383 ? -36.213 -0.842 9.218 1.00 76.30 ? 356 PHE B CD2 1 ATOM 2471 C CE1 . PHE A 1 383 ? -37.872 0.842 10.681 1.00 68.28 ? 356 PHE B CE1 1 ATOM 2472 C CE2 . PHE A 1 383 ? -35.711 -0.120 10.289 1.00 75.15 ? 356 PHE B CE2 1 ATOM 2473 C CZ . PHE A 1 383 ? -36.538 0.725 11.017 1.00 66.88 ? 356 PHE B CZ 1 ATOM 2474 N N . ASN A 1 384 ? -39.926 -4.365 6.825 1.00 88.34 ? 357 ASN B N 1 ATOM 2475 C CA . ASN A 1 384 ? -40.730 -5.063 5.841 1.00 85.91 ? 357 ASN B CA 1 ATOM 2476 C C . ASN A 1 384 ? -40.317 -4.713 4.415 1.00 79.05 ? 357 ASN B C 1 ATOM 2477 O O . ASN A 1 384 ? -41.157 -4.498 3.578 1.00 77.75 ? 357 ASN B O 1 ATOM 2478 C CB . ASN A 1 384 ? -42.199 -4.721 6.083 1.00 88.10 ? 357 ASN B CB 1 ATOM 2479 C CG . ASN A 1 384 ? -43.113 -5.879 5.807 1.00 89.36 ? 357 ASN B CG 1 ATOM 2480 O OD1 . ASN A 1 384 ? -43.995 -6.184 6.613 1.00 101.72 ? 357 ASN B OD1 1 ATOM 2481 N ND2 . ASN A 1 384 ? -42.906 -6.545 4.683 1.00 80.96 ? 357 ASN B ND2 1 ATOM 2482 N N . CYS A 1 385 ? -39.015 -4.687 4.152 1.00 79.72 ? 358 CYS B N 1 ATOM 2483 C CA . CYS A 1 385 ? -38.486 -4.245 2.878 1.00 82.19 ? 358 CYS B CA 1 ATOM 2484 C C . CYS A 1 385 ? -37.286 -5.118 2.421 1.00 83.29 ? 358 CYS B C 1 ATOM 2485 O O . CYS A 1 385 ? -37.057 -6.176 2.983 1.00 83.73 ? 358 CYS B O 1 ATOM 2486 C CB . CYS A 1 385 ? -38.117 -2.769 3.029 1.00 89.53 ? 358 CYS B CB 1 ATOM 2487 S SG . CYS A 1 385 ? -36.887 -2.418 4.300 1.00 87.50 ? 358 CYS B SG 1 ATOM 2488 N N . HIS A 1 386 ? -36.538 -4.682 1.404 1.00 80.71 ? 359 HIS B N 1 ATOM 2489 C CA . HIS A 1 386 ? -35.430 -5.449 0.833 1.00 79.12 ? 359 HIS B CA 1 ATOM 2490 C C . HIS A 1 386 ? -34.253 -4.509 0.623 1.00 85.74 ? 359 HIS B C 1 ATOM 2491 O O . HIS A 1 386 ? -34.443 -3.304 0.574 1.00 97.11 ? 359 HIS B O 1 ATOM 2492 C CB . HIS A 1 386 ? -35.881 -6.033 -0.501 1.00 87.41 ? 359 HIS B CB 1 ATOM 2493 C CG . HIS A 1 386 ? -34.816 -6.781 -1.237 1.00 87.83 ? 359 HIS B CG 1 ATOM 2494 N ND1 . HIS A 1 386 ? -34.615 -8.133 -1.074 1.00 96.71 ? 359 HIS B ND1 1 ATOM 2495 C CD2 . HIS A 1 386 ? -33.908 -6.373 -2.156 1.00 86.02 ? 359 HIS B CD2 1 ATOM 2496 C CE1 . HIS A 1 386 ? -33.622 -8.526 -1.853 1.00 98.92 ? 359 HIS B CE1 1 ATOM 2497 N NE2 . HIS A 1 386 ? -33.171 -7.475 -2.516 1.00 91.63 ? 359 HIS B NE2 1 ATOM 2498 N N . LEU A 1 387 ? -33.045 -5.048 0.473 1.00 92.41 ? 360 LEU B N 1 ATOM 2499 C CA . LEU A 1 387 ? -31.816 -4.246 0.473 1.00 96.09 ? 360 LEU B CA 1 ATOM 2500 C C . LEU A 1 387 ? -30.936 -4.381 -0.780 1.00 100.53 ? 360 LEU B C 1 ATOM 2501 O O . LEU A 1 387 ? -30.670 -5.495 -1.235 1.00 107.47 ? 360 LEU B O 1 ATOM 2502 C CB . LEU A 1 387 ? -30.990 -4.676 1.685 1.00 106.25 ? 360 LEU B CB 1 ATOM 2503 C CG . LEU A 1 387 ? -30.346 -3.598 2.559 1.00 107.25 ? 360 LEU B CG 1 ATOM 2504 C CD1 . LEU A 1 387 ? -31.378 -2.633 3.142 1.00 106.76 ? 360 LEU B CD1 1 ATOM 2505 C CD2 . LEU A 1 387 ? -29.569 -4.298 3.662 1.00 107.37 ? 360 LEU B CD2 1 ATOM 2506 N N . GLN A 1 388 ? -30.445 -3.250 -1.297 1.00 106.77 ? 361 GLN B N 1 ATOM 2507 C CA . GLN A 1 388 ? -29.565 -3.235 -2.483 1.00 105.94 ? 361 GLN B CA 1 ATOM 2508 C C . GLN A 1 388 ? -28.164 -3.748 -2.157 1.00 96.94 ? 361 GLN B C 1 ATOM 2509 O O . GLN A 1 388 ? -27.858 -4.917 -2.387 1.00 90.75 ? 361 GLN B O 1 ATOM 2510 C CB . GLN A 1 388 ? -29.465 -1.818 -3.072 1.00 106.82 ? 361 GLN B CB 1 ATOM 2511 N N . PHE A 1 418 ? -44.205 -7.558 -4.946 1.00 99.62 ? 391 PHE B N 1 ATOM 2512 C CA . PHE A 1 418 ? -43.061 -6.644 -4.846 1.00 83.83 ? 391 PHE B CA 1 ATOM 2513 C C . PHE A 1 418 ? -42.764 -6.347 -3.389 1.00 80.04 ? 391 PHE B C 1 ATOM 2514 O O . PHE A 1 418 ? -43.648 -5.977 -2.623 1.00 81.91 ? 391 PHE B O 1 ATOM 2515 C CB . PHE A 1 418 ? -43.338 -5.323 -5.589 1.00 72.76 ? 391 PHE B CB 1 ATOM 2516 C CG . PHE A 1 418 ? -42.162 -4.402 -5.652 1.00 62.44 ? 391 PHE B CG 1 ATOM 2517 C CD1 . PHE A 1 418 ? -40.951 -4.832 -6.212 1.00 65.10 ? 391 PHE B CD1 1 ATOM 2518 C CD2 . PHE A 1 418 ? -42.257 -3.089 -5.187 1.00 66.22 ? 391 PHE B CD2 1 ATOM 2519 C CE1 . PHE A 1 418 ? -39.839 -3.983 -6.291 1.00 67.32 ? 391 PHE B CE1 1 ATOM 2520 C CE2 . PHE A 1 418 ? -41.149 -2.227 -5.258 1.00 72.89 ? 391 PHE B CE2 1 ATOM 2521 C CZ . PHE A 1 418 ? -39.938 -2.672 -5.814 1.00 72.61 ? 391 PHE B CZ 1 ATOM 2522 N N . ARG A 1 419 ? -41.513 -6.507 -3.013 1.00 75.70 ? 392 ARG B N 1 ATOM 2523 C CA . ARG A 1 419 ? -41.102 -6.180 -1.681 1.00 75.49 ? 392 ARG B CA 1 ATOM 2524 C C . ARG A 1 419 ? -40.422 -4.830 -1.805 1.00 69.75 ? 392 ARG B C 1 ATOM 2525 O O . ARG A 1 419 ? -39.427 -4.690 -2.505 1.00 61.36 ? 392 ARG B O 1 ATOM 2526 C CB . ARG A 1 419 ? -40.154 -7.265 -1.175 1.00 86.85 ? 392 ARG B CB 1 ATOM 2527 C CG . ARG A 1 419 ? -39.959 -7.289 0.328 1.00 95.47 ? 392 ARG B CG 1 ATOM 2528 C CD . ARG A 1 419 ? -39.757 -8.712 0.829 1.00 99.02 ? 392 ARG B CD 1 ATOM 2529 N NE . ARG A 1 419 ? -38.967 -8.757 2.061 1.00 104.41 ? 392 ARG B NE 1 ATOM 2530 C CZ . ARG A 1 419 ? -39.407 -8.387 3.265 1.00 110.38 ? 392 ARG B CZ 1 ATOM 2531 N NH1 . ARG A 1 419 ? -40.643 -7.923 3.435 1.00 115.70 ? 392 ARG B NH1 1 ATOM 2532 N NH2 . ARG A 1 419 ? -38.601 -8.471 4.318 1.00 106.59 ? 392 ARG B NH2 1 ATOM 2533 N N . PRO A 1 420 ? -40.955 -3.817 -1.132 1.00 75.74 ? 393 PRO B N 1 ATOM 2534 C CA . PRO A 1 420 ? -40.396 -2.478 -1.394 1.00 77.93 ? 393 PRO B CA 1 ATOM 2535 C C . PRO A 1 420 ? -38.931 -2.436 -1.050 1.00 76.65 ? 393 PRO B C 1 ATOM 2536 O O . PRO A 1 420 ? -38.571 -3.059 -0.070 1.00 92.45 ? 393 PRO B O 1 ATOM 2537 C CB . PRO A 1 420 ? -41.196 -1.560 -0.464 1.00 79.18 ? 393 PRO B CB 1 ATOM 2538 C CG . PRO A 1 420 ? -41.971 -2.451 0.471 1.00 77.76 ? 393 PRO B CG 1 ATOM 2539 C CD . PRO A 1 420 ? -41.938 -3.857 -0.031 1.00 75.31 ? 393 PRO B CD 1 ATOM 2540 N N . LEU A 1 421 ? -38.086 -1.755 -1.830 1.00 78.21 ? 394 LEU B N 1 ATOM 2541 C CA . LEU A 1 421 ? -36.663 -1.569 -1.427 1.00 87.15 ? 394 LEU B CA 1 ATOM 2542 C C . LEU A 1 421 ? -36.532 -0.660 -0.172 1.00 97.09 ? 394 LEU B C 1 ATOM 2543 O O . LEU A 1 421 ? -37.447 0.129 0.125 1.00 95.35 ? 394 LEU B O 1 ATOM 2544 C CB . LEU A 1 421 ? -35.813 -1.023 -2.575 1.00 82.64 ? 394 LEU B CB 1 ATOM 2545 N N . CYS A 1 422 ? -35.420 -0.796 0.569 1.00 101.12 ? 395 CYS B N 1 ATOM 2546 C CA . CYS A 1 422 ? -35.215 -0.068 1.849 1.00 102.93 ? 395 CYS B CA 1 ATOM 2547 C C . CYS A 1 422 ? -34.352 1.169 1.652 1.00 98.87 ? 395 CYS B C 1 ATOM 2548 O O . CYS A 1 422 ? -33.288 1.092 1.018 1.00 83.89 ? 395 CYS B O 1 ATOM 2549 C CB . CYS A 1 422 ? -34.526 -0.929 2.932 1.00 106.56 ? 395 CYS B CB 1 ATOM 2550 S SG . CYS A 1 422 ? -35.139 -2.610 3.253 1.00 111.70 ? 395 CYS B SG 1 ATOM 2551 N N . THR A 1 423 ? -34.786 2.287 2.249 1.00 104.93 ? 396 THR B N 1 ATOM 2552 C CA . THR A 1 423 ? -34.095 3.589 2.113 1.00 95.72 ? 396 THR B CA 1 ATOM 2553 C C . THR A 1 423 ? -32.697 3.468 2.667 1.00 91.49 ? 396 THR B C 1 ATOM 2554 O O . THR A 1 423 ? -31.763 4.003 2.094 1.00 89.40 ? 396 THR B O 1 ATOM 2555 C CB . THR A 1 423 ? -34.814 4.783 2.840 1.00 102.23 ? 396 THR B CB 1 ATOM 2556 O OG1 . THR A 1 423 ? -34.565 4.752 4.251 1.00 97.11 ? 396 THR B OG1 1 ATOM 2557 C CG2 . THR A 1 423 ? -36.339 4.799 2.613 1.00 106.73 ? 396 THR B CG2 1 ATOM 2558 N N . GLY A 1 424 ? -32.578 2.732 3.775 1.00 96.67 ? 397 GLY B N 1 ATOM 2559 C CA . GLY A 1 424 ? -31.379 2.704 4.599 1.00 93.41 ? 397 GLY B CA 1 ATOM 2560 C C . GLY A 1 424 ? -31.468 3.722 5.733 1.00 97.48 ? 397 GLY B C 1 ATOM 2561 O O . GLY A 1 424 ? -30.715 3.644 6.697 1.00 102.44 ? 397 GLY B O 1 ATOM 2562 N N . ASP A 1 425 ? -32.407 4.663 5.636 1.00 96.17 ? 398 ASP B N 1 ATOM 2563 C CA . ASP A 1 425 ? -32.466 5.808 6.538 1.00 96.58 ? 398 ASP B CA 1 ATOM 2564 C C . ASP A 1 425 ? -33.714 5.745 7.427 1.00 89.39 ? 398 ASP B C 1 ATOM 2565 O O . ASP A 1 425 ? -34.091 6.746 8.052 1.00 90.22 ? 398 ASP B O 1 ATOM 2566 C CB . ASP A 1 425 ? -32.444 7.128 5.729 1.00 102.30 ? 398 ASP B CB 1 ATOM 2567 C CG . ASP A 1 425 ? -31.230 7.240 4.773 1.00 109.59 ? 398 ASP B CG 1 ATOM 2568 O OD1 . ASP A 1 425 ? -30.091 6.905 5.167 1.00 112.57 ? 398 ASP B OD1 1 ATOM 2569 O OD2 . ASP A 1 425 ? -31.414 7.683 3.619 1.00 109.01 ? 398 ASP B OD2 1 ATOM 2570 N N . GLU A 1 426 ? -34.355 4.579 7.497 1.00 79.68 ? 399 GLU B N 1 ATOM 2571 C CA . GLU A 1 426 ? -35.556 4.433 8.348 1.00 78.46 ? 399 GLU B CA 1 ATOM 2572 C C . GLU A 1 426 ? -35.190 4.337 9.859 1.00 74.93 ? 399 GLU B C 1 ATOM 2573 O O . GLU A 1 426 ? -34.012 4.207 10.213 1.00 66.93 ? 399 GLU B O 1 ATOM 2574 C CB . GLU A 1 426 ? -36.477 3.283 7.877 1.00 78.24 ? 399 GLU B CB 1 ATOM 2575 C CG . GLU A 1 426 ? -35.803 2.047 7.286 1.00 82.56 ? 399 GLU B CG 1 ATOM 2576 C CD . GLU A 1 426 ? -35.681 2.034 5.760 1.00 86.51 ? 399 GLU B CD 1 ATOM 2577 O OE1 . GLU A 1 426 ? -36.689 2.254 5.059 1.00 93.31 ? 399 GLU B OE1 1 ATOM 2578 O OE2 . GLU A 1 426 ? -34.575 1.753 5.252 1.00 77.49 ? 399 GLU B OE2 1 ATOM 2579 N N . ASN A 1 427 ? -36.190 4.448 10.735 1.00 70.98 ? 400 ASN B N 1 ATOM 2580 C CA . ASN A 1 427 ? -35.955 4.679 12.163 1.00 74.56 ? 400 ASN B CA 1 ATOM 2581 C C . ASN A 1 427 ? -36.470 3.561 13.053 1.00 77.64 ? 400 ASN B C 1 ATOM 2582 O O . ASN A 1 427 ? -37.676 3.270 13.072 1.00 71.91 ? 400 ASN B O 1 ATOM 2583 C CB . ASN A 1 427 ? -36.596 5.999 12.614 1.00 83.19 ? 400 ASN B CB 1 ATOM 2584 C CG . ASN A 1 427 ? -36.074 6.468 13.973 1.00 92.21 ? 400 ASN B CG 1 ATOM 2585 O OD1 . ASN A 1 427 ? -36.346 5.857 15.023 1.00 97.20 ? 400 ASN B OD1 1 ATOM 2586 N ND2 . ASN A 1 427 ? -35.308 7.553 13.957 1.00 90.01 ? 400 ASN B ND2 1 ATOM 2587 N N . ILE A 1 428 ? -35.555 2.977 13.828 1.00 79.34 ? 401 ILE B N 1 ATOM 2588 C CA . ILE A 1 428 ? -35.887 1.852 14.714 1.00 84.09 ? 401 ILE B CA 1 ATOM 2589 C C . ILE A 1 428 ? -37.010 2.163 15.698 1.00 81.12 ? 401 ILE B C 1 ATOM 2590 O O . ILE A 1 428 ? -37.787 1.278 16.057 1.00 86.71 ? 401 ILE B O 1 ATOM 2591 C CB . ILE A 1 428 ? -34.631 1.324 15.458 1.00 86.30 ? 401 ILE B CB 1 ATOM 2592 C CG1 . ILE A 1 428 ? -33.920 0.301 14.578 1.00 84.94 ? 401 ILE B CG1 1 ATOM 2593 C CG2 . ILE A 1 428 ? -34.980 0.653 16.783 1.00 84.88 ? 401 ILE B CG2 1 ATOM 2594 C CD1 . ILE A 1 428 ? -32.487 0.082 14.974 1.00 88.50 ? 401 ILE B CD1 1 ATOM 2595 N N . SER A 1 429 ? -37.115 3.421 16.112 1.00 83.19 ? 402 SER B N 1 ATOM 2596 C CA . SER A 1 429 ? -38.104 3.800 17.110 1.00 80.93 ? 402 SER B CA 1 ATOM 2597 C C . SER A 1 429 ? -39.566 3.892 16.559 1.00 78.38 ? 402 SER B C 1 ATOM 2598 O O . SER A 1 429 ? -40.502 4.094 17.327 1.00 77.25 ? 402 SER B O 1 ATOM 2599 C CB . SER A 1 429 ? -37.644 5.090 17.820 1.00 74.29 ? 402 SER B CB 1 ATOM 2600 N N . SER A 1 430 ? -39.780 3.703 15.257 1.00 78.17 ? 403 SER B N 1 ATOM 2601 C CA . SER A 1 430 ? -41.146 3.806 14.672 1.00 79.94 ? 403 SER B CA 1 ATOM 2602 C C . SER A 1 430 ? -41.954 2.503 14.650 1.00 89.01 ? 403 SER B C 1 ATOM 2603 O O . SER A 1 430 ? -43.183 2.533 14.604 1.00 86.37 ? 403 SER B O 1 ATOM 2604 C CB . SER A 1 430 ? -41.072 4.343 13.243 1.00 75.36 ? 403 SER B CB 1 ATOM 2605 O OG . SER A 1 430 ? -40.006 3.719 12.546 1.00 75.47 ? 403 SER B OG 1 ATOM 2606 N N . VAL A 1 431 ? -41.266 1.363 14.647 1.00 99.11 ? 404 VAL B N 1 ATOM 2607 C CA . VAL A 1 431 ? -41.925 0.064 14.589 1.00 92.16 ? 404 VAL B CA 1 ATOM 2608 C C . VAL A 1 431 ? -41.730 -0.607 15.937 1.00 89.89 ? 404 VAL B C 1 ATOM 2609 O O . VAL A 1 431 ? -40.590 -0.805 16.347 1.00 93.61 ? 404 VAL B O 1 ATOM 2610 C CB . VAL A 1 431 ? -41.307 -0.835 13.495 1.00 96.93 ? 404 VAL B CB 1 ATOM 2611 C CG1 . VAL A 1 431 ? -42.296 -1.907 13.065 1.00 93.93 ? 404 VAL B CG1 1 ATOM 2612 C CG2 . VAL A 1 431 ? -40.858 -0.011 12.295 1.00 96.94 ? 404 VAL B CG2 1 ATOM 2613 N N . GLU A 1 432 ? -42.832 -0.929 16.620 1.00 87.84 ? 405 GLU B N 1 ATOM 2614 C CA . GLU A 1 432 ? -42.809 -1.691 17.882 1.00 84.95 ? 405 GLU B CA 1 ATOM 2615 C C . GLU A 1 432 ? -42.519 -3.168 17.603 1.00 82.97 ? 405 GLU B C 1 ATOM 2616 O O . GLU A 1 432 ? -43.381 -3.871 17.072 1.00 90.15 ? 405 GLU B O 1 ATOM 2617 C CB . GLU A 1 432 ? -44.158 -1.589 18.627 1.00 80.71 ? 405 GLU B CB 1 ATOM 2618 N N . THR A 1 433 ? -41.303 -3.615 17.939 1.00 82.91 ? 406 THR B N 1 ATOM 2619 C CA . THR A 1 433 ? -40.917 -5.046 17.963 1.00 72.07 ? 406 THR B CA 1 ATOM 2620 C C . THR A 1 433 ? -40.268 -5.358 19.284 1.00 67.31 ? 406 THR B C 1 ATOM 2621 O O . THR A 1 433 ? -39.731 -4.472 19.921 1.00 73.43 ? 406 THR B O 1 ATOM 2622 C CB . THR A 1 433 ? -39.876 -5.415 16.888 1.00 72.17 ? 406 THR B CB 1 ATOM 2623 O OG1 . THR A 1 433 ? -38.637 -4.721 17.130 1.00 62.62 ? 406 THR B OG1 1 ATOM 2624 C CG2 . THR A 1 433 ? -40.412 -5.096 15.488 1.00 72.11 ? 406 THR B CG2 1 ATOM 2625 N N . PRO A 1 434 ? -40.270 -6.629 19.688 1.00 68.18 ? 407 PRO B N 1 ATOM 2626 C CA . PRO A 1 434 ? -39.596 -7.008 20.946 1.00 64.57 ? 407 PRO B CA 1 ATOM 2627 C C . PRO A 1 434 ? -38.130 -6.580 21.095 1.00 61.48 ? 407 PRO B C 1 ATOM 2628 O O . PRO A 1 434 ? -37.638 -6.471 22.209 1.00 69.53 ? 407 PRO B O 1 ATOM 2629 C CB . PRO A 1 434 ? -39.715 -8.533 20.943 1.00 68.31 ? 407 PRO B CB 1 ATOM 2630 C CG . PRO A 1 434 ? -41.021 -8.785 20.212 1.00 67.55 ? 407 PRO B CG 1 ATOM 2631 C CD . PRO A 1 434 ? -41.093 -7.730 19.143 1.00 65.19 ? 407 PRO B CD 1 ATOM 2632 N N . TYR A 1 435 ? -37.442 -6.316 19.994 1.00 57.84 ? 408 TYR B N 1 ATOM 2633 C CA . TYR A 1 435 ? -36.077 -5.822 20.038 1.00 53.04 ? 408 TYR B CA 1 ATOM 2634 C C . TYR A 1 435 ? -35.878 -4.712 21.042 1.00 57.47 ? 408 TYR B C 1 ATOM 2635 O O . TYR A 1 435 ? -34.966 -4.757 21.855 1.00 65.69 ? 408 TYR B O 1 ATOM 2636 C CB . TYR A 1 435 ? -35.715 -5.284 18.692 1.00 49.35 ? 408 TYR B CB 1 ATOM 2637 C CG . TYR A 1 435 ? -34.302 -4.853 18.573 1.00 56.75 ? 408 TYR B CG 1 ATOM 2638 C CD1 . TYR A 1 435 ? -33.288 -5.774 18.642 1.00 59.01 ? 408 TYR B CD1 1 ATOM 2639 C CD2 . TYR A 1 435 ? -33.967 -3.531 18.319 1.00 60.96 ? 408 TYR B CD2 1 ATOM 2640 C CE1 . TYR A 1 435 ? -31.977 -5.397 18.490 1.00 58.49 ? 408 TYR B CE1 1 ATOM 2641 C CE2 . TYR A 1 435 ? -32.640 -3.145 18.165 1.00 59.42 ? 408 TYR B CE2 1 ATOM 2642 C CZ . TYR A 1 435 ? -31.649 -4.091 18.256 1.00 54.58 ? 408 TYR B CZ 1 ATOM 2643 O OH . TYR A 1 435 ? -30.308 -3.792 18.120 1.00 53.04 ? 408 TYR B OH 1 ATOM 2644 N N . ILE A 1 436 ? -36.736 -3.704 20.974 1.00 63.04 ? 409 ILE B N 1 ATOM 2645 C CA . ILE A 1 436 ? -36.632 -2.555 21.856 1.00 60.27 ? 409 ILE B CA 1 ATOM 2646 C C . ILE A 1 436 ? -37.842 -2.383 22.781 1.00 59.68 ? 409 ILE B C 1 ATOM 2647 O O . ILE A 1 436 ? -37.705 -1.800 23.830 1.00 59.99 ? 409 ILE B O 1 ATOM 2648 C CB . ILE A 1 436 ? -36.350 -1.290 21.025 1.00 69.07 ? 409 ILE B CB 1 ATOM 2649 C CG1 . ILE A 1 436 ? -35.138 -0.576 21.578 1.00 69.88 ? 409 ILE B CG1 1 ATOM 2650 C CG2 . ILE A 1 436 ? -37.558 -0.360 20.918 1.00 80.41 ? 409 ILE B CG2 1 ATOM 2651 C CD1 . ILE A 1 436 ? -33.842 -1.247 21.185 1.00 68.24 ? 409 ILE B CD1 1 ATOM 2652 N N . ASP A 1 437 ? -39.010 -2.909 22.420 1.00 67.75 ? 410 ASP B N 1 ATOM 2653 C CA . ASP A 1 437 ? -40.229 -2.731 23.220 1.00 76.88 ? 410 ASP B CA 1 ATOM 2654 C C . ASP A 1 437 ? -40.141 -3.720 24.381 1.00 74.94 ? 410 ASP B C 1 ATOM 2655 O O . ASP A 1 437 ? -40.817 -4.746 24.393 1.00 73.94 ? 410 ASP B O 1 ATOM 2656 C CB . ASP A 1 437 ? -41.504 -2.916 22.346 1.00 82.88 ? 410 ASP B CB 1 ATOM 2657 C CG . ASP A 1 437 ? -42.828 -2.678 23.110 1.00 93.55 ? 410 ASP B CG 1 ATOM 2658 O OD1 . ASP A 1 437 ? -42.807 -2.272 24.292 1.00 101.12 ? 410 ASP B OD1 1 ATOM 2659 O OD2 . ASP A 1 437 ? -43.915 -2.903 22.516 1.00 107.02 ? 410 ASP B OD2 1 ATOM 2660 N N . TYR A 1 438 ? -39.275 -3.392 25.342 1.00 71.67 ? 411 TYR B N 1 ATOM 2661 C CA . TYR A 1 438 ? -39.118 -4.160 26.583 1.00 68.46 ? 411 TYR B CA 1 ATOM 2662 C C . TYR A 1 438 ? -38.907 -3.188 27.717 1.00 65.56 ? 411 TYR B C 1 ATOM 2663 O O . TYR A 1 438 ? -38.363 -2.115 27.524 1.00 68.61 ? 411 TYR B O 1 ATOM 2664 C CB . TYR A 1 438 ? -37.890 -5.082 26.526 1.00 64.10 ? 411 TYR B CB 1 ATOM 2665 C CG . TYR A 1 438 ? -36.571 -4.331 26.480 1.00 54.35 ? 411 TYR B CG 1 ATOM 2666 C CD1 . TYR A 1 438 ? -35.957 -3.898 27.641 1.00 52.25 ? 411 TYR B CD1 1 ATOM 2667 C CD2 . TYR A 1 438 ? -35.943 -4.068 25.282 1.00 49.28 ? 411 TYR B CD2 1 ATOM 2668 C CE1 . TYR A 1 438 ? -34.764 -3.211 27.611 1.00 46.85 ? 411 TYR B CE1 1 ATOM 2669 C CE2 . TYR A 1 438 ? -34.745 -3.393 25.247 1.00 48.93 ? 411 TYR B CE2 1 ATOM 2670 C CZ . TYR A 1 438 ? -34.178 -2.954 26.417 1.00 47.74 ? 411 TYR B CZ 1 ATOM 2671 O OH . TYR A 1 438 ? -32.998 -2.273 26.383 1.00 53.58 ? 411 TYR B OH 1 ATOM 2672 N N . THR A 1 439 ? -39.258 -3.599 28.919 1.00 69.31 ? 412 THR B N 1 ATOM 2673 C CA . THR A 1 439 ? -38.988 -2.774 30.069 1.00 73.85 ? 412 THR B CA 1 ATOM 2674 C C . THR A 1 439 ? -37.805 -3.351 30.865 1.00 67.54 ? 412 THR B C 1 ATOM 2675 O O . THR A 1 439 ? -36.798 -2.671 31.002 1.00 70.48 ? 412 THR B O 1 ATOM 2676 C CB . THR A 1 439 ? -40.253 -2.483 30.910 1.00 84.87 ? 412 THR B CB 1 ATOM 2677 O OG1 . THR A 1 439 ? -39.880 -2.331 32.284 1.00 90.81 ? 412 THR B OG1 1 ATOM 2678 C CG2 . THR A 1 439 ? -41.325 -3.595 30.762 1.00 91.18 ? 412 THR B CG2 1 ATOM 2679 N N . HIS A 1 440 ? -37.890 -4.601 31.322 1.00 64.48 ? 413 HIS B N 1 ATOM 2680 C CA . HIS A 1 440 ? -36.778 -5.272 32.058 1.00 61.18 ? 413 HIS B CA 1 ATOM 2681 C C . HIS A 1 440 ? -35.936 -6.233 31.211 1.00 56.26 ? 413 HIS B C 1 ATOM 2682 O O . HIS A 1 440 ? -36.466 -7.015 30.433 1.00 59.24 ? 413 HIS B O 1 ATOM 2683 C CB . HIS A 1 440 ? -37.322 -6.090 33.211 1.00 65.64 ? 413 HIS B CB 1 ATOM 2684 C CG . HIS A 1 440 ? -38.306 -5.358 34.060 1.00 74.07 ? 413 HIS B CG 1 ATOM 2685 N ND1 . HIS A 1 440 ? -37.953 -4.726 35.233 1.00 81.46 ? 413 HIS B ND1 1 ATOM 2686 C CD2 . HIS A 1 440 ? -39.638 -5.166 33.914 1.00 77.37 ? 413 HIS B CD2 1 ATOM 2687 C CE1 . HIS A 1 440 ? -39.024 -4.169 35.768 1.00 83.22 ? 413 HIS B CE1 1 ATOM 2688 N NE2 . HIS A 1 440 ? -40.059 -4.424 34.990 1.00 81.16 ? 413 HIS B NE2 1 ATOM 2689 N N . LEU A 1 441 ? -34.622 -6.168 31.392 1.00 58.36 ? 414 LEU B N 1 ATOM 2690 C CA . LEU A 1 441 ? -33.665 -7.068 30.766 1.00 53.66 ? 414 LEU B CA 1 ATOM 2691 C C . LEU A 1 441 ? -33.451 -8.222 31.699 1.00 52.32 ? 414 LEU B C 1 ATOM 2692 O O . LEU A 1 441 ? -32.980 -8.027 32.793 1.00 58.76 ? 414 LEU B O 1 ATOM 2693 C CB . LEU A 1 441 ? -32.331 -6.386 30.588 1.00 52.20 ? 414 LEU B CB 1 ATOM 2694 C CG . LEU A 1 441 ? -32.245 -5.289 29.549 1.00 55.22 ? 414 LEU B CG 1 ATOM 2695 C CD1 . LEU A 1 441 ? -30.822 -4.769 29.515 1.00 58.84 ? 414 LEU B CD1 1 ATOM 2696 C CD2 . LEU A 1 441 ? -32.613 -5.776 28.155 1.00 57.72 ? 414 LEU B CD2 1 ATOM 2697 N N . ARG A 1 442 ? -33.803 -9.422 31.262 1.00 52.78 ? 415 ARG B N 1 ATOM 2698 C CA . ARG A 1 442 ? -33.693 -10.605 32.087 1.00 49.36 ? 415 ARG B CA 1 ATOM 2699 C C . ARG A 1 442 ? -32.726 -11.603 31.461 1.00 46.45 ? 415 ARG B C 1 ATOM 2700 O O . ARG A 1 442 ? -31.579 -11.648 31.888 1.00 50.88 ? 415 ARG B O 1 ATOM 2701 C CB . ARG A 1 442 ? -35.076 -11.170 32.376 1.00 49.20 ? 415 ARG B CB 1 ATOM 2702 C CG . ARG A 1 442 ? -36.057 -10.120 32.887 1.00 48.31 ? 415 ARG B CG 1 ATOM 2703 C CD . ARG A 1 442 ? -37.296 -10.785 33.475 1.00 53.02 ? 415 ARG B CD 1 ATOM 2704 N NE . ARG A 1 442 ? -38.463 -9.903 33.616 1.00 59.14 ? 415 ARG B NE 1 ATOM 2705 C CZ . ARG A 1 442 ? -38.908 -9.347 34.755 1.00 63.60 ? 415 ARG B CZ 1 ATOM 2706 N NH1 . ARG A 1 442 ? -38.292 -9.517 35.924 1.00 59.47 ? 415 ARG B NH1 1 ATOM 2707 N NH2 . ARG A 1 442 ? -39.998 -8.584 34.719 1.00 71.93 ? 415 ARG B NH2 1 ATOM 2708 N N . ILE A 1 443 ? -33.136 -12.367 30.450 1.00 45.57 ? 416 ILE B N 1 ATOM 2709 C CA . ILE A 1 443 ? -32.191 -13.235 29.692 1.00 42.02 ? 416 ILE B CA 1 ATOM 2710 C C . ILE A 1 443 ? -31.011 -12.434 29.138 1.00 42.13 ? 416 ILE B C 1 ATOM 2711 O O . ILE A 1 443 ? -29.876 -12.869 29.199 1.00 48.49 ? 416 ILE B O 1 ATOM 2712 C CB . ILE A 1 443 ? -32.858 -13.946 28.514 1.00 41.15 ? 416 ILE B CB 1 ATOM 2713 C CG1 . ILE A 1 443 ? -34.054 -14.836 28.951 1.00 46.19 ? 416 ILE B CG1 1 ATOM 2714 C CG2 . ILE A 1 443 ? -31.854 -14.766 27.762 1.00 39.73 ? 416 ILE B CG2 1 ATOM 2715 C CD1 . ILE A 1 443 ? -33.784 -15.858 30.021 1.00 46.41 ? 416 ILE B CD1 1 ATOM 2716 N N . SER A 1 444 ? -31.254 -11.242 28.630 1.00 44.37 ? 417 SER B N 1 ATOM 2717 C CA . SER A 1 444 ? -30.158 -10.391 28.128 1.00 45.15 ? 417 SER B CA 1 ATOM 2718 C C . SER A 1 444 ? -29.090 -10.174 29.211 1.00 44.45 ? 417 SER B C 1 ATOM 2719 O O . SER A 1 444 ? -27.887 -10.163 28.968 1.00 41.65 ? 417 SER B O 1 ATOM 2720 C CB . SER A 1 444 ? -30.731 -9.059 27.645 1.00 48.05 ? 417 SER B CB 1 ATOM 2721 O OG . SER A 1 444 ? -31.812 -9.264 26.706 1.00 49.37 ? 417 SER B OG 1 ATOM 2722 N N . TYR A 1 445 ? -29.538 -10.019 30.433 1.00 46.56 ? 418 TYR B N 1 ATOM 2723 C CA . TYR A 1 445 ? -28.612 -9.832 31.497 1.00 46.04 ? 418 TYR B CA 1 ATOM 2724 C C . TYR A 1 445 ? -27.775 -11.095 31.645 1.00 48.32 ? 418 TYR B C 1 ATOM 2725 O O . TYR A 1 445 ? -26.557 -11.010 31.756 1.00 49.93 ? 418 TYR B O 1 ATOM 2726 C CB . TYR A 1 445 ? -29.331 -9.459 32.791 1.00 46.27 ? 418 TYR B CB 1 ATOM 2727 C CG . TYR A 1 445 ? -28.344 -9.087 33.862 1.00 52.65 ? 418 TYR B CG 1 ATOM 2728 C CD1 . TYR A 1 445 ? -27.532 -7.937 33.730 1.00 52.09 ? 418 TYR B CD1 1 ATOM 2729 C CD2 . TYR A 1 445 ? -28.169 -9.897 34.973 1.00 54.29 ? 418 TYR B CD2 1 ATOM 2730 C CE1 . TYR A 1 445 ? -26.591 -7.615 34.678 1.00 53.90 ? 418 TYR B CE1 1 ATOM 2731 C CE2 . TYR A 1 445 ? -27.223 -9.586 35.944 1.00 59.83 ? 418 TYR B CE2 1 ATOM 2732 C CZ . TYR A 1 445 ? -26.436 -8.450 35.799 1.00 62.99 ? 418 TYR B CZ 1 ATOM 2733 O OH . TYR A 1 445 ? -25.508 -8.161 36.778 1.00 60.40 ? 418 TYR B OH 1 ATOM 2734 N N . ASN A 1 446 ? -28.408 -12.266 31.612 1.00 44.98 ? 419 ASN B N 1 ATOM 2735 C CA . ASN A 1 446 ? -27.651 -13.523 31.649 1.00 44.33 ? 419 ASN B CA 1 ATOM 2736 C C . ASN A 1 446 ? -26.609 -13.712 30.544 1.00 41.31 ? 419 ASN B C 1 ATOM 2737 O O . ASN A 1 446 ? -25.552 -14.327 30.737 1.00 39.68 ? 419 ASN B O 1 ATOM 2738 C CB . ASN A 1 446 ? -28.579 -14.698 31.551 1.00 47.20 ? 419 ASN B CB 1 ATOM 2739 C CG . ASN A 1 446 ? -29.499 -14.796 32.703 1.00 46.83 ? 419 ASN B CG 1 ATOM 2740 O OD1 . ASN A 1 446 ? -29.415 -14.031 33.654 1.00 52.42 ? 419 ASN B OD1 1 ATOM 2741 N ND2 . ASN A 1 446 ? -30.402 -15.750 32.623 1.00 52.70 ? 419 ASN B ND2 1 ATOM 2742 N N . VAL A 1 447 ? -26.928 -13.204 29.378 1.00 39.43 ? 420 VAL B N 1 ATOM 2743 C CA . VAL A 1 447 ? -25.983 -13.227 28.286 1.00 41.80 ? 420 VAL B CA 1 ATOM 2744 C C . VAL A 1 447 ? -24.771 -12.404 28.664 1.00 43.15 ? 420 VAL B C 1 ATOM 2745 O O . VAL A 1 447 ? -23.637 -12.800 28.454 1.00 41.63 ? 420 VAL B O 1 ATOM 2746 C CB . VAL A 1 447 ? -26.612 -12.622 27.022 1.00 40.91 ? 420 VAL B CB 1 ATOM 2747 C CG1 . VAL A 1 447 ? -25.664 -12.745 25.827 1.00 41.50 ? 420 VAL B CG1 1 ATOM 2748 C CG2 . VAL A 1 447 ? -27.928 -13.330 26.737 1.00 43.67 ? 420 VAL B CG2 1 ATOM 2749 N N . TYR A 1 448 ? -25.050 -11.233 29.207 1.00 48.60 ? 421 TYR B N 1 ATOM 2750 C CA . TYR A 1 448 ? -24.045 -10.282 29.580 1.00 48.33 ? 421 TYR B CA 1 ATOM 2751 C C . TYR A 1 448 ? -23.176 -10.878 30.669 1.00 50.80 ? 421 TYR B C 1 ATOM 2752 O O . TYR A 1 448 ? -21.944 -10.818 30.558 1.00 53.20 ? 421 TYR B O 1 ATOM 2753 C CB . TYR A 1 448 ? -24.757 -9.065 30.060 1.00 50.34 ? 421 TYR B CB 1 ATOM 2754 C CG . TYR A 1 448 ? -23.921 -7.951 30.522 1.00 57.30 ? 421 TYR B CG 1 ATOM 2755 C CD1 . TYR A 1 448 ? -23.281 -7.122 29.604 1.00 60.30 ? 421 TYR B CD1 1 ATOM 2756 C CD2 . TYR A 1 448 ? -23.825 -7.653 31.886 1.00 60.85 ? 421 TYR B CD2 1 ATOM 2757 C CE1 . TYR A 1 448 ? -22.545 -6.034 30.033 1.00 64.36 ? 421 TYR B CE1 1 ATOM 2758 C CE2 . TYR A 1 448 ? -23.093 -6.563 32.327 1.00 64.25 ? 421 TYR B CE2 1 ATOM 2759 C CZ . TYR A 1 448 ? -22.454 -5.759 31.394 1.00 65.14 ? 421 TYR B CZ 1 ATOM 2760 O OH . TYR A 1 448 ? -21.716 -4.693 31.815 1.00 66.79 ? 421 TYR B OH 1 ATOM 2761 N N . LEU A 1 449 ? -23.789 -11.513 31.674 1.00 45.53 ? 422 LEU B N 1 ATOM 2762 C CA . LEU A 1 449 ? -22.996 -12.197 32.720 1.00 46.35 ? 422 LEU B CA 1 ATOM 2763 C C . LEU A 1 449 ? -22.275 -13.415 32.230 1.00 45.56 ? 422 LEU B C 1 ATOM 2764 O O . LEU A 1 449 ? -21.264 -13.819 32.808 1.00 47.63 ? 422 LEU B O 1 ATOM 2765 C CB . LEU A 1 449 ? -23.828 -12.664 33.903 1.00 48.46 ? 422 LEU B CB 1 ATOM 2766 C CG . LEU A 1 449 ? -24.456 -11.673 34.863 1.00 50.39 ? 422 LEU B CG 1 ATOM 2767 C CD1 . LEU A 1 449 ? -24.997 -12.493 36.012 1.00 52.95 ? 422 LEU B CD1 1 ATOM 2768 C CD2 . LEU A 1 449 ? -23.440 -10.688 35.380 1.00 55.26 ? 422 LEU B CD2 1 ATOM 2769 N N . ALA A 1 450 ? -22.798 -14.062 31.215 1.00 45.12 ? 423 ALA B N 1 ATOM 2770 C CA . ALA A 1 450 ? -22.114 -15.247 30.768 1.00 48.93 ? 423 ALA B CA 1 ATOM 2771 C C . ALA A 1 450 ? -20.780 -14.811 30.167 1.00 47.59 ? 423 ALA B C 1 ATOM 2772 O O . ALA A 1 450 ? -19.763 -15.474 30.354 1.00 48.31 ? 423 ALA B O 1 ATOM 2773 C CB . ALA A 1 450 ? -22.965 -16.038 29.771 1.00 46.80 ? 423 ALA B CB 1 ATOM 2774 N N . VAL A 1 451 ? -20.802 -13.707 29.439 1.00 46.09 ? 424 VAL B N 1 ATOM 2775 C CA . VAL A 1 451 ? -19.604 -13.190 28.766 1.00 54.07 ? 424 VAL B CA 1 ATOM 2776 C C . VAL A 1 451 ? -18.570 -12.630 29.758 1.00 52.11 ? 424 VAL B C 1 ATOM 2777 O O . VAL A 1 451 ? -17.369 -12.786 29.572 1.00 53.34 ? 424 VAL B O 1 ATOM 2778 C CB . VAL A 1 451 ? -19.969 -12.054 27.769 1.00 56.56 ? 424 VAL B CB 1 ATOM 2779 C CG1 . VAL A 1 451 ? -18.733 -11.288 27.324 1.00 56.07 ? 424 VAL B CG1 1 ATOM 2780 C CG2 . VAL A 1 451 ? -20.722 -12.607 26.560 1.00 56.81 ? 424 VAL B CG2 1 ATOM 2781 N N . TYR A 1 452 ? -19.058 -11.938 30.774 1.00 50.96 ? 425 TYR B N 1 ATOM 2782 C CA . TYR A 1 452 ? -18.218 -11.376 31.806 1.00 53.16 ? 425 TYR B CA 1 ATOM 2783 C C . TYR A 1 452 ? -17.539 -12.493 32.645 1.00 53.30 ? 425 TYR B C 1 ATOM 2784 O O . TYR A 1 452 ? -16.402 -12.357 33.059 1.00 58.82 ? 425 TYR B O 1 ATOM 2785 C CB . TYR A 1 452 ? -19.040 -10.373 32.653 1.00 51.88 ? 425 TYR B CB 1 ATOM 2786 C CG . TYR A 1 452 ? -18.788 -8.956 32.173 1.00 56.18 ? 425 TYR B CG 1 ATOM 2787 C CD1 . TYR A 1 452 ? -17.688 -8.237 32.622 1.00 55.14 ? 425 TYR B CD1 1 ATOM 2788 C CD2 . TYR A 1 452 ? -19.601 -8.358 31.237 1.00 57.59 ? 425 TYR B CD2 1 ATOM 2789 C CE1 . TYR A 1 452 ? -17.429 -6.968 32.178 1.00 53.20 ? 425 TYR B CE1 1 ATOM 2790 C CE2 . TYR A 1 452 ? -19.357 -7.077 30.802 1.00 57.19 ? 425 TYR B CE2 1 ATOM 2791 C CZ . TYR A 1 452 ? -18.257 -6.393 31.265 1.00 56.81 ? 425 TYR B CZ 1 ATOM 2792 O OH . TYR A 1 452 ? -17.983 -5.126 30.799 1.00 56.60 ? 425 TYR B OH 1 ATOM 2793 N N . SER A 1 453 ? -18.220 -13.613 32.832 1.00 49.20 ? 426 SER B N 1 ATOM 2794 C CA . SER A 1 453 ? -17.641 -14.783 33.483 1.00 47.14 ? 426 SER B CA 1 ATOM 2795 C C . SER A 1 453 ? -16.445 -15.260 32.706 1.00 46.69 ? 426 SER B C 1 ATOM 2796 O O . SER A 1 453 ? -15.372 -15.464 33.249 1.00 53.48 ? 426 SER B O 1 ATOM 2797 C CB . SER A 1 453 ? -18.673 -15.917 33.584 1.00 44.91 ? 426 SER B CB 1 ATOM 2798 O OG . SER A 1 453 ? -19.850 -15.421 34.236 1.00 49.71 ? 426 SER B OG 1 ATOM 2799 N N . ILE A 1 454 ? -16.610 -15.439 31.421 1.00 46.74 ? 427 ILE B N 1 ATOM 2800 C CA . ILE A 1 454 ? -15.522 -15.962 30.643 1.00 47.95 ? 427 ILE B CA 1 ATOM 2801 C C . ILE A 1 454 ? -14.412 -14.958 30.705 1.00 51.66 ? 427 ILE B C 1 ATOM 2802 O O . ILE A 1 454 ? -13.243 -15.355 30.689 1.00 49.54 ? 427 ILE B O 1 ATOM 2803 C CB . ILE A 1 454 ? -15.921 -16.176 29.194 1.00 46.02 ? 427 ILE B CB 1 ATOM 2804 C CG1 . ILE A 1 454 ? -16.780 -17.419 29.127 1.00 49.41 ? 427 ILE B CG1 1 ATOM 2805 C CG2 . ILE A 1 454 ? -14.700 -16.388 28.319 1.00 46.32 ? 427 ILE B CG2 1 ATOM 2806 C CD1 . ILE A 1 454 ? -17.752 -17.415 27.975 1.00 50.58 ? 427 ILE B CD1 1 ATOM 2807 N N . ALA A 1 455 ? -14.773 -13.671 30.764 1.00 49.90 ? 428 ALA B N 1 ATOM 2808 C CA . ALA A 1 455 ? -13.781 -12.602 30.637 1.00 53.70 ? 428 ALA B CA 1 ATOM 2809 C C . ALA A 1 455 ? -12.951 -12.552 31.901 1.00 54.04 ? 428 ALA B C 1 ATOM 2810 O O . ALA A 1 455 ? -11.725 -12.697 31.854 1.00 50.44 ? 428 ALA B O 1 ATOM 2811 C CB . ALA A 1 455 ? -14.445 -11.261 30.376 1.00 54.84 ? 428 ALA B CB 1 ATOM 2812 N N . HIS A 1 456 ? -13.650 -12.409 33.024 1.00 54.85 ? 429 HIS B N 1 ATOM 2813 C CA . HIS A 1 456 ? -13.060 -12.515 34.357 1.00 54.04 ? 429 HIS B CA 1 ATOM 2814 C C . HIS A 1 456 ? -12.178 -13.768 34.632 1.00 53.50 ? 429 HIS B C 1 ATOM 2815 O O . HIS A 1 456 ? -11.188 -13.671 35.332 1.00 58.14 ? 429 HIS B O 1 ATOM 2816 C CB . HIS A 1 456 ? -14.155 -12.383 35.401 1.00 50.34 ? 429 HIS B CB 1 ATOM 2817 C CG . HIS A 1 456 ? -14.609 -10.972 35.599 1.00 58.42 ? 429 HIS B CG 1 ATOM 2818 N ND1 . HIS A 1 456 ? -13.772 -9.988 36.066 1.00 63.53 ? 429 HIS B ND1 1 ATOM 2819 C CD2 . HIS A 1 456 ? -15.808 -10.376 35.399 1.00 68.63 ? 429 HIS B CD2 1 ATOM 2820 C CE1 . HIS A 1 456 ? -14.432 -8.847 36.149 1.00 65.81 ? 429 HIS B CE1 1 ATOM 2821 N NE2 . HIS A 1 456 ? -15.670 -9.054 35.747 1.00 68.75 ? 429 HIS B NE2 1 ATOM 2822 N N . ALA A 1 457 ? -12.510 -14.920 34.077 1.00 51.38 ? 430 ALA B N 1 ATOM 2823 C CA . ALA A 1 457 ? -11.693 -16.102 34.272 1.00 51.11 ? 430 ALA B CA 1 ATOM 2824 C C . ALA A 1 457 ? -10.449 -15.999 33.449 1.00 55.70 ? 430 ALA B C 1 ATOM 2825 O O . ALA A 1 457 ? -9.442 -16.585 33.790 1.00 64.20 ? 430 ALA B O 1 ATOM 2826 C CB . ALA A 1 457 ? -12.455 -17.345 33.876 1.00 53.25 ? 430 ALA B CB 1 ATOM 2827 N N . LEU A 1 458 ? -10.526 -15.274 32.339 1.00 62.65 ? 431 LEU B N 1 ATOM 2828 C CA . LEU A 1 458 ? -9.329 -14.941 31.548 1.00 61.97 ? 431 LEU B CA 1 ATOM 2829 C C . LEU A 1 458 ? -8.508 -13.887 32.275 1.00 58.29 ? 431 LEU B C 1 ATOM 2830 O O . LEU A 1 458 ? -7.288 -13.924 32.231 1.00 61.47 ? 431 LEU B O 1 ATOM 2831 C CB . LEU A 1 458 ? -9.676 -14.434 30.136 1.00 56.10 ? 431 LEU B CB 1 ATOM 2832 C CG . LEU A 1 458 ? -10.302 -15.459 29.208 1.00 54.01 ? 431 LEU B CG 1 ATOM 2833 C CD1 . LEU A 1 458 ? -10.975 -14.759 28.061 1.00 58.40 ? 431 LEU B CD1 1 ATOM 2834 C CD2 . LEU A 1 458 ? -9.301 -16.452 28.688 1.00 54.00 ? 431 LEU B CD2 1 ATOM 2835 N N . GLN A 1 459 ? -9.175 -12.952 32.929 1.00 54.04 ? 432 GLN B N 1 ATOM 2836 C CA . GLN A 1 459 ? -8.477 -11.962 33.716 1.00 63.77 ? 432 GLN B CA 1 ATOM 2837 C C . GLN A 1 459 ? -7.751 -12.605 34.888 1.00 69.30 ? 432 GLN B C 1 ATOM 2838 O O . GLN A 1 459 ? -6.723 -12.077 35.330 1.00 69.78 ? 432 GLN B O 1 ATOM 2839 C CB . GLN A 1 459 ? -9.432 -10.897 34.233 1.00 67.45 ? 432 GLN B CB 1 ATOM 2840 C CG . GLN A 1 459 ? -8.784 -9.800 35.067 1.00 75.58 ? 432 GLN B CG 1 ATOM 2841 C CD . GLN A 1 459 ? -7.818 -8.919 34.292 1.00 84.56 ? 432 GLN B CD 1 ATOM 2842 O OE1 . GLN A 1 459 ? -7.590 -9.100 33.086 1.00 93.47 ? 432 GLN B OE1 1 ATOM 2843 N NE2 . GLN A 1 459 ? -7.241 -7.950 34.989 1.00 87.33 ? 432 GLN B NE2 1 ATOM 2844 N N . ASP A 1 460 ? -8.276 -13.733 35.386 1.00 66.38 ? 433 ASP B N 1 ATOM 2845 C CA . ASP A 1 460 ? -7.655 -14.425 36.520 1.00 61.23 ? 433 ASP B CA 1 ATOM 2846 C C . ASP A 1 460 ? -6.372 -15.103 36.049 1.00 64.30 ? 433 ASP B C 1 ATOM 2847 O O . ASP A 1 460 ? -5.454 -15.300 36.838 1.00 77.64 ? 433 ASP B O 1 ATOM 2848 C CB . ASP A 1 460 ? -8.616 -15.412 37.212 1.00 54.38 ? 433 ASP B CB 1 ATOM 2849 C CG . ASP A 1 460 ? -9.712 -14.700 38.079 1.00 57.30 ? 433 ASP B CG 1 ATOM 2850 O OD1 . ASP A 1 460 ? -9.654 -13.475 38.298 1.00 54.01 ? 433 ASP B OD1 1 ATOM 2851 O OD2 . ASP A 1 460 ? -10.668 -15.371 38.553 1.00 61.04 ? 433 ASP B OD2 1 ATOM 2852 N N . ILE A 1 461 ? -6.310 -15.425 34.763 1.00 63.23 ? 434 ILE B N 1 ATOM 2853 C CA . ILE A 1 461 ? -5.128 -15.993 34.143 1.00 64.17 ? 434 ILE B CA 1 ATOM 2854 C C . ILE A 1 461 ? -4.120 -14.901 33.751 1.00 71.65 ? 434 ILE B C 1 ATOM 2855 O O . ILE A 1 461 ? -2.914 -15.140 33.778 1.00 75.13 ? 434 ILE B O 1 ATOM 2856 C CB . ILE A 1 461 ? -5.503 -16.786 32.885 1.00 60.74 ? 434 ILE B CB 1 ATOM 2857 C CG1 . ILE A 1 461 ? -6.252 -18.052 33.273 1.00 60.25 ? 434 ILE B CG1 1 ATOM 2858 C CG2 . ILE A 1 461 ? -4.264 -17.156 32.097 1.00 64.53 ? 434 ILE B CG2 1 ATOM 2859 C CD1 . ILE A 1 461 ? -6.768 -18.843 32.086 1.00 59.59 ? 434 ILE B CD1 1 ATOM 2860 N N . TYR A 1 462 ? -4.599 -13.717 33.374 1.00 69.33 ? 435 TYR B N 1 ATOM 2861 C CA . TYR A 1 462 ? -3.702 -12.619 33.053 1.00 69.33 ? 435 TYR B CA 1 ATOM 2862 C C . TYR A 1 462 ? -2.858 -12.234 34.270 1.00 72.90 ? 435 TYR B C 1 ATOM 2863 O O . TYR A 1 462 ? -1.640 -12.126 34.173 1.00 74.65 ? 435 TYR B O 1 ATOM 2864 C CB . TYR A 1 462 ? -4.477 -11.401 32.586 1.00 72.13 ? 435 TYR B CB 1 ATOM 2865 C CG . TYR A 1 462 ? -3.586 -10.223 32.230 1.00 82.79 ? 435 TYR B CG 1 ATOM 2866 C CD1 . TYR A 1 462 ? -2.683 -10.306 31.168 1.00 83.92 ? 435 TYR B CD1 1 ATOM 2867 C CD2 . TYR A 1 462 ? -3.643 -9.027 32.958 1.00 83.83 ? 435 TYR B CD2 1 ATOM 2868 C CE1 . TYR A 1 462 ? -1.864 -9.243 30.843 1.00 84.81 ? 435 TYR B CE1 1 ATOM 2869 C CE2 . TYR A 1 462 ? -2.832 -7.956 32.632 1.00 87.58 ? 435 TYR B CE2 1 ATOM 2870 C CZ . TYR A 1 462 ? -1.947 -8.074 31.571 1.00 90.72 ? 435 TYR B CZ 1 ATOM 2871 O OH . TYR A 1 462 ? -1.133 -7.020 31.233 1.00 98.07 ? 435 TYR B OH 1 ATOM 2872 N N . THR A 1 463 ? -3.535 -12.050 35.402 1.00 70.02 ? 436 THR B N 1 ATOM 2873 C CA . THR A 1 463 ? -2.940 -11.683 36.685 1.00 62.45 ? 436 THR B CA 1 ATOM 2874 C C . THR A 1 463 ? -2.427 -12.869 37.560 1.00 69.61 ? 436 THR B C 1 ATOM 2875 O O . THR A 1 463 ? -2.034 -12.645 38.706 1.00 74.51 ? 436 THR B O 1 ATOM 2876 C CB . THR A 1 463 ? -4.002 -10.997 37.569 1.00 58.98 ? 436 THR B CB 1 ATOM 2877 O OG1 . THR A 1 463 ? -5.022 -11.954 37.907 1.00 64.10 ? 436 THR B OG1 1 ATOM 2878 C CG2 . THR A 1 463 ? -4.643 -9.814 36.893 1.00 54.24 ? 436 THR B CG2 1 ATOM 2879 N N . CYS A 1 464 ? -2.463 -14.111 37.073 1.00 74.02 ? 437 CYS B N 1 ATOM 2880 C CA . CYS A 1 464 ? -1.991 -15.255 37.877 1.00 79.54 ? 437 CYS B CA 1 ATOM 2881 C C . CYS A 1 464 ? -0.525 -15.079 38.270 1.00 82.69 ? 437 CYS B C 1 ATOM 2882 O O . CYS A 1 464 ? 0.329 -14.775 37.422 1.00 75.00 ? 437 CYS B O 1 ATOM 2883 C CB . CYS A 1 464 ? -2.145 -16.580 37.118 1.00 83.76 ? 437 CYS B CB 1 ATOM 2884 S SG . CYS A 1 464 ? -1.598 -18.051 38.028 1.00 96.98 ? 437 CYS B SG 1 ATOM 2885 N N . LEU A 1 465 ? -0.252 -15.287 39.559 1.00 92.27 ? 438 LEU B N 1 ATOM 2886 C CA . LEU A 1 465 ? 1.099 -15.185 40.132 1.00 87.86 ? 438 LEU B CA 1 ATOM 2887 C C . LEU A 1 465 ? 1.715 -16.564 40.326 1.00 73.19 ? 438 LEU B C 1 ATOM 2888 O O . LEU A 1 465 ? 1.169 -17.390 41.068 1.00 63.88 ? 438 LEU B O 1 ATOM 2889 C CB . LEU A 1 465 ? 1.019 -14.474 41.478 1.00 98.60 ? 438 LEU B CB 1 ATOM 2890 C CG . LEU A 1 465 ? 0.623 -13.001 41.365 1.00 108.14 ? 438 LEU B CG 1 ATOM 2891 C CD1 . LEU A 1 465 ? 0.227 -12.429 42.727 1.00 111.04 ? 438 LEU B CD1 1 ATOM 2892 C CD2 . LEU A 1 465 ? 1.752 -12.196 40.702 1.00 103.34 ? 438 LEU B CD2 1 ATOM 2893 N N . PRO A 1 466 ? 2.870 -16.812 39.693 1.00 77.20 ? 439 PRO B N 1 ATOM 2894 C CA . PRO A 1 466 ? 3.397 -18.188 39.708 1.00 81.02 ? 439 PRO B CA 1 ATOM 2895 C C . PRO A 1 466 ? 3.538 -18.687 41.142 1.00 71.51 ? 439 PRO B C 1 ATOM 2896 O O . PRO A 1 466 ? 3.925 -17.926 42.016 1.00 69.21 ? 439 PRO B O 1 ATOM 2897 C CB . PRO A 1 466 ? 4.770 -18.073 39.012 1.00 82.68 ? 439 PRO B CB 1 ATOM 2898 C CG . PRO A 1 466 ? 4.994 -16.624 38.697 1.00 78.33 ? 439 PRO B CG 1 ATOM 2899 C CD . PRO A 1 466 ? 3.914 -15.819 39.371 1.00 81.22 ? 439 PRO B CD 1 ATOM 2900 N N . GLY A 1 467 ? 3.183 -19.931 41.393 1.00 67.47 ? 440 GLY B N 1 ATOM 2901 C CA . GLY A 1 467 ? 3.096 -20.413 42.778 1.00 76.89 ? 440 GLY B CA 1 ATOM 2902 C C . GLY A 1 467 ? 1.691 -20.395 43.371 1.00 79.16 ? 440 GLY B C 1 ATOM 2903 O O . GLY A 1 467 ? 1.237 -21.408 43.925 1.00 77.02 ? 440 GLY B O 1 ATOM 2904 N N . ARG A 1 468 ? 1.000 -19.259 43.243 1.00 84.46 ? 441 ARG B N 1 ATOM 2905 C CA . ARG A 1 468 ? -0.413 -19.135 43.656 1.00 91.12 ? 441 ARG B CA 1 ATOM 2906 C C . ARG A 1 468 ? -1.403 -19.240 42.441 1.00 86.41 ? 441 ARG B C 1 ATOM 2907 O O . ARG A 1 468 ? -2.373 -18.485 42.340 1.00 74.82 ? 441 ARG B O 1 ATOM 2908 C CB . ARG A 1 468 ? -0.617 -17.841 44.485 1.00 86.15 ? 441 ARG B CB 1 ATOM 2909 N N . GLY A 1 469 ? -1.139 -20.194 41.541 1.00 82.81 ? 442 GLY B N 1 ATOM 2910 C CA . GLY A 1 469 ? -2.017 -20.517 40.408 1.00 77.12 ? 442 GLY B CA 1 ATOM 2911 C C . GLY A 1 469 ? -2.746 -21.842 40.612 1.00 75.01 ? 442 GLY B C 1 ATOM 2912 O O . GLY A 1 469 ? -2.512 -22.540 41.591 1.00 81.77 ? 442 GLY B O 1 ATOM 2913 N N . LEU A 1 470 ? -3.627 -22.203 39.683 1.00 72.80 ? 443 LEU B N 1 ATOM 2914 C CA . LEU A 1 470 ? -4.537 -23.334 39.890 1.00 67.02 ? 443 LEU B CA 1 ATOM 2915 C C . LEU A 1 470 ? -4.089 -24.638 39.243 1.00 66.59 ? 443 LEU B C 1 ATOM 2916 O O . LEU A 1 470 ? -4.772 -25.648 39.395 1.00 67.43 ? 443 LEU B O 1 ATOM 2917 C CB . LEU A 1 470 ? -5.947 -23.005 39.376 1.00 67.38 ? 443 LEU B CB 1 ATOM 2918 C CG . LEU A 1 470 ? -6.747 -21.887 40.044 1.00 64.18 ? 443 LEU B CG 1 ATOM 2919 C CD1 . LEU A 1 470 ? -7.979 -21.625 39.216 1.00 66.58 ? 443 LEU B CD1 1 ATOM 2920 C CD2 . LEU A 1 470 ? -7.152 -22.226 41.446 1.00 62.72 ? 443 LEU B CD2 1 ATOM 2921 N N . PHE A 1 471 ? -2.961 -24.643 38.534 1.00 66.78 ? 444 PHE B N 1 ATOM 2922 C CA . PHE A 1 471 ? -2.494 -25.870 37.871 1.00 66.56 ? 444 PHE B CA 1 ATOM 2923 C C . PHE A 1 471 ? -1.368 -26.540 38.685 1.00 73.26 ? 444 PHE B C 1 ATOM 2924 O O . PHE A 1 471 ? -1.082 -26.086 39.792 1.00 90.95 ? 444 PHE B O 1 ATOM 2925 C CB . PHE A 1 471 ? -2.148 -25.523 36.429 1.00 67.21 ? 444 PHE B CB 1 ATOM 2926 C CG . PHE A 1 471 ? -3.272 -24.804 35.725 1.00 64.60 ? 444 PHE B CG 1 ATOM 2927 C CD1 . PHE A 1 471 ? -4.325 -25.515 35.166 1.00 66.94 ? 444 PHE B CD1 1 ATOM 2928 C CD2 . PHE A 1 471 ? -3.318 -23.418 35.693 1.00 65.29 ? 444 PHE B CD2 1 ATOM 2929 C CE1 . PHE A 1 471 ? -5.390 -24.860 34.567 1.00 71.79 ? 444 PHE B CE1 1 ATOM 2930 C CE2 . PHE A 1 471 ? -4.375 -22.749 35.085 1.00 71.05 ? 444 PHE B CE2 1 ATOM 2931 C CZ . PHE A 1 471 ? -5.419 -23.469 34.527 1.00 70.57 ? 444 PHE B CZ 1 ATOM 2932 N N . THR A 1 472 ? -0.767 -27.629 38.202 1.00 70.95 ? 445 THR B N 1 ATOM 2933 C CA . THR A 1 472 ? 0.189 -28.395 39.023 1.00 72.71 ? 445 THR B CA 1 ATOM 2934 C C . THR A 1 472 ? 1.300 -27.503 39.610 1.00 80.13 ? 445 THR B C 1 ATOM 2935 O O . THR A 1 472 ? 1.734 -26.532 38.952 1.00 70.47 ? 445 THR B O 1 ATOM 2936 C CB . THR A 1 472 ? 0.865 -29.515 38.220 1.00 77.92 ? 445 THR B CB 1 ATOM 2937 O OG1 . THR A 1 472 ? 1.282 -28.993 36.961 1.00 82.02 ? 445 THR B OG1 1 ATOM 2938 C CG2 . THR A 1 472 ? -0.082 -30.687 37.979 1.00 83.73 ? 445 THR B CG2 1 ATOM 2939 N N . ASN A 1 473 ? 1.731 -27.841 40.842 1.00 80.85 ? 446 ASN B N 1 ATOM 2940 C CA . ASN A 1 473 ? 2.800 -27.135 41.595 1.00 80.30 ? 446 ASN B CA 1 ATOM 2941 C C . ASN A 1 473 ? 2.578 -25.610 41.646 1.00 83.03 ? 446 ASN B C 1 ATOM 2942 O O . ASN A 1 473 ? 3.520 -24.803 41.495 1.00 85.73 ? 446 ASN B O 1 ATOM 2943 C CB . ASN A 1 473 ? 4.211 -27.470 41.039 1.00 84.05 ? 446 ASN B CB 1 ATOM 2944 C CG . ASN A 1 473 ? 4.593 -28.944 41.209 1.00 87.82 ? 446 ASN B CG 1 ATOM 2945 O OD1 . ASN A 1 473 ? 4.130 -29.620 42.127 1.00 93.43 ? 446 ASN B OD1 1 ATOM 2946 N ND2 . ASN A 1 473 ? 5.441 -29.446 40.317 1.00 90.49 ? 446 ASN B ND2 1 ATOM 2947 N N . GLY A 1 474 ? 1.318 -25.221 41.840 1.00 74.78 ? 447 GLY B N 1 ATOM 2948 C CA . GLY A 1 474 ? 0.923 -23.806 41.815 1.00 68.60 ? 447 GLY B CA 1 ATOM 2949 C C . GLY A 1 474 ? 1.207 -23.070 40.512 1.00 67.74 ? 447 GLY B C 1 ATOM 2950 O O . GLY A 1 474 ? 1.247 -21.856 40.507 1.00 69.66 ? 447 GLY B O 1 ATOM 2951 N N . SER A 1 475 ? 1.398 -23.776 39.398 1.00 64.08 ? 448 SER B N 1 ATOM 2952 C CA . SER A 1 475 ? 1.760 -23.103 38.154 1.00 65.30 ? 448 SER B CA 1 ATOM 2953 C C . SER A 1 475 ? 0.579 -22.352 37.523 1.00 69.70 ? 448 SER B C 1 ATOM 2954 O O . SER A 1 475 ? -0.588 -22.666 37.776 1.00 71.81 ? 448 SER B O 1 ATOM 2955 C CB . SER A 1 475 ? 2.329 -24.096 37.142 1.00 65.65 ? 448 SER B CB 1 ATOM 2956 O OG . SER A 1 475 ? 1.310 -24.898 36.581 1.00 70.28 ? 448 SER B OG 1 ATOM 2957 N N . CYS A 1 476 ? 0.910 -21.361 36.701 1.00 73.00 ? 449 CYS B N 1 ATOM 2958 C CA . CYS A 1 476 ? -0.071 -20.582 35.971 1.00 73.06 ? 449 CYS B CA 1 ATOM 2959 C C . CYS A 1 476 ? -0.296 -21.116 34.555 1.00 74.16 ? 449 CYS B C 1 ATOM 2960 O O . CYS A 1 476 ? 0.343 -22.077 34.121 1.00 76.19 ? 449 CYS B O 1 ATOM 2961 C CB . CYS A 1 476 ? 0.368 -19.120 35.916 1.00 75.51 ? 449 CYS B CB 1 ATOM 2962 S SG . CYS A 1 476 ? 0.385 -18.279 37.526 1.00 81.34 ? 449 CYS B SG 1 ATOM 2963 N N . ALA A 1 477 ? -1.245 -20.501 33.857 1.00 77.48 ? 450 ALA B N 1 ATOM 2964 C CA . ALA A 1 477 ? -1.439 -20.731 32.429 1.00 72.32 ? 450 ALA B CA 1 ATOM 2965 C C . ALA A 1 477 ? -0.923 -19.517 31.680 1.00 67.65 ? 450 ALA B C 1 ATOM 2966 O O . ALA A 1 477 ? -1.044 -18.401 32.175 1.00 72.37 ? 450 ALA B O 1 ATOM 2967 C CB . ALA A 1 477 ? -2.903 -20.939 32.132 1.00 68.66 ? 450 ALA B CB 1 ATOM 2968 N N . ASP A 1 478 ? -0.334 -19.739 30.512 1.00 64.17 ? 451 ASP B N 1 ATOM 2969 C CA . ASP A 1 478 ? 0.128 -18.649 29.653 1.00 71.05 ? 451 ASP B CA 1 ATOM 2970 C C . ASP A 1 478 ? -1.040 -18.078 28.848 1.00 69.86 ? 451 ASP B C 1 ATOM 2971 O O . ASP A 1 478 ? -1.557 -18.754 27.946 1.00 72.57 ? 451 ASP B O 1 ATOM 2972 C CB . ASP A 1 478 ? 1.229 -19.162 28.694 1.00 77.01 ? 451 ASP B CB 1 ATOM 2973 C CG . ASP A 1 478 ? 1.610 -18.136 27.614 1.00 84.81 ? 451 ASP B CG 1 ATOM 2974 O OD1 . ASP A 1 478 ? 1.573 -16.906 27.876 1.00 68.55 ? 451 ASP B OD1 1 ATOM 2975 O OD2 . ASP A 1 478 ? 1.944 -18.574 26.487 1.00 104.73 ? 451 ASP B OD2 1 ATOM 2976 N N . ILE A 1 479 ? -1.432 -16.838 29.138 1.00 63.24 ? 452 ILE B N 1 ATOM 2977 C CA . ILE A 1 479 ? -2.500 -16.203 28.378 1.00 69.31 ? 452 ILE B CA 1 ATOM 2978 C C . ILE A 1 479 ? -2.161 -15.962 26.900 1.00 79.09 ? 452 ILE B C 1 ATOM 2979 O O . ILE A 1 479 ? -3.061 -15.883 26.058 1.00 82.06 ? 452 ILE B O 1 ATOM 2980 C CB . ILE A 1 479 ? -3.003 -14.891 29.010 1.00 73.67 ? 452 ILE B CB 1 ATOM 2981 C CG1 . ILE A 1 479 ? -4.377 -14.534 28.419 1.00 72.71 ? 452 ILE B CG1 1 ATOM 2982 C CG2 . ILE A 1 479 ? -2.011 -13.757 28.813 1.00 72.20 ? 452 ILE B CG2 1 ATOM 2983 C CD1 . ILE A 1 479 ? -5.170 -13.528 29.231 1.00 76.36 ? 452 ILE B CD1 1 ATOM 2984 N N . LYS A 1 480 ? -0.877 -15.850 26.574 1.00 85.07 ? 453 LYS B N 1 ATOM 2985 C CA . LYS A 1 480 ? -0.468 -15.743 25.174 1.00 83.62 ? 453 LYS B CA 1 ATOM 2986 C C . LYS A 1 480 ? -0.830 -17.021 24.427 1.00 77.45 ? 453 LYS B C 1 ATOM 2987 O O . LYS A 1 480 ? -1.046 -16.978 23.234 1.00 87.26 ? 453 LYS B O 1 ATOM 2988 C CB . LYS A 1 480 ? 1.049 -15.492 25.025 1.00 97.18 ? 453 LYS B CB 1 ATOM 2989 C CG . LYS A 1 480 ? 1.627 -14.264 25.736 1.00 101.44 ? 453 LYS B CG 1 ATOM 2990 C CD . LYS A 1 480 ? 1.085 -12.961 25.171 1.00 101.88 ? 453 LYS B CD 1 ATOM 2991 C CE . LYS A 1 480 ? 1.338 -11.796 26.114 1.00 109.49 ? 453 LYS B CE 1 ATOM 2992 N NZ . LYS A 1 480 ? 0.156 -10.885 26.164 1.00 111.18 ? 453 LYS B NZ 1 ATOM 2993 N N . LYS A 1 481 ? -0.886 -18.153 25.122 1.00 74.01 ? 454 LYS B N 1 ATOM 2994 C CA . LYS A 1 481 ? -1.145 -19.452 24.488 1.00 76.57 ? 454 LYS B CA 1 ATOM 2995 C C . LYS A 1 481 ? -2.203 -20.293 25.272 1.00 74.52 ? 454 LYS B C 1 ATOM 2996 O O . LYS A 1 481 ? -1.969 -21.471 25.551 1.00 69.82 ? 454 LYS B O 1 ATOM 2997 C CB . LYS A 1 481 ? 0.182 -20.230 24.339 1.00 68.73 ? 454 LYS B CB 1 ATOM 2998 N N . VAL A 1 482 ? -3.365 -19.697 25.578 1.00 66.64 ? 455 VAL B N 1 ATOM 2999 C CA . VAL A 1 482 ? -4.384 -20.334 26.454 1.00 64.77 ? 455 VAL B CA 1 ATOM 3000 C C . VAL A 1 482 ? -5.145 -21.453 25.779 1.00 61.23 ? 455 VAL B C 1 ATOM 3001 O O . VAL A 1 482 ? -5.550 -21.299 24.638 1.00 61.56 ? 455 VAL B O 1 ATOM 3002 C CB . VAL A 1 482 ? -5.547 -19.417 26.895 1.00 70.37 ? 455 VAL B CB 1 ATOM 3003 C CG1 . VAL A 1 482 ? -5.953 -19.768 28.313 1.00 76.35 ? 455 VAL B CG1 1 ATOM 3004 C CG2 . VAL A 1 482 ? -5.228 -17.946 26.795 1.00 78.78 ? 455 VAL B CG2 1 ATOM 3005 N N . GLU A 1 483 ? -5.400 -22.532 26.519 1.00 56.40 ? 456 GLU B N 1 ATOM 3006 C CA . GLU A 1 483 ? -6.200 -23.659 26.047 1.00 61.92 ? 456 GLU B CA 1 ATOM 3007 C C . GLU A 1 483 ? -7.576 -23.718 26.741 1.00 64.51 ? 456 GLU B C 1 ATOM 3008 O O . GLU A 1 483 ? -7.709 -23.372 27.911 1.00 60.28 ? 456 GLU B O 1 ATOM 3009 C CB . GLU A 1 483 ? -5.433 -24.942 26.249 1.00 63.91 ? 456 GLU B CB 1 ATOM 3010 C CG . GLU A 1 483 ? -4.048 -24.847 25.636 1.00 74.15 ? 456 GLU B CG 1 ATOM 3011 C CD . GLU A 1 483 ? -3.338 -26.182 25.550 1.00 86.92 ? 456 GLU B CD 1 ATOM 3012 O OE1 . GLU A 1 483 ? -2.903 -26.725 26.598 1.00 84.00 ? 456 GLU B OE1 1 ATOM 3013 O OE2 . GLU A 1 483 ? -3.205 -26.680 24.414 1.00 101.87 ? 456 GLU B OE2 1 ATOM 3014 N N . ALA A 1 484 ? -8.603 -24.145 26.003 1.00 60.73 ? 457 ALA B N 1 ATOM 3015 C CA . ALA A 1 484 ? -9.972 -24.105 26.504 1.00 57.10 ? 457 ALA B CA 1 ATOM 3016 C C . ALA A 1 484 ? -10.114 -24.689 27.898 1.00 52.28 ? 457 ALA B C 1 ATOM 3017 O O . ALA A 1 484 ? -10.740 -24.078 28.750 1.00 54.52 ? 457 ALA B O 1 ATOM 3018 C CB . ALA A 1 484 ? -10.920 -24.810 25.560 1.00 58.32 ? 457 ALA B CB 1 ATOM 3019 N N . TRP A 1 485 ? -9.513 -25.844 28.133 1.00 49.58 ? 458 TRP B N 1 ATOM 3020 C CA . TRP A 1 485 ? -9.642 -26.504 29.419 1.00 52.55 ? 458 TRP B CA 1 ATOM 3021 C C . TRP A 1 485 ? -9.131 -25.663 30.617 1.00 54.70 ? 458 TRP B C 1 ATOM 3022 O O . TRP A 1 485 ? -9.563 -25.849 31.770 1.00 50.43 ? 458 TRP B O 1 ATOM 3023 C CB . TRP A 1 485 ? -8.984 -27.895 29.375 1.00 53.94 ? 458 TRP B CB 1 ATOM 3024 C CG . TRP A 1 485 ? -7.506 -27.867 29.287 1.00 61.36 ? 458 TRP B CG 1 ATOM 3025 C CD1 . TRP A 1 485 ? -6.744 -27.883 28.141 1.00 67.73 ? 458 TRP B CD1 1 ATOM 3026 C CD2 . TRP A 1 485 ? -6.587 -27.813 30.376 1.00 64.60 ? 458 TRP B CD2 1 ATOM 3027 N NE1 . TRP A 1 485 ? -5.409 -27.834 28.456 1.00 64.39 ? 458 TRP B NE1 1 ATOM 3028 C CE2 . TRP A 1 485 ? -5.281 -27.789 29.821 1.00 67.82 ? 458 TRP B CE2 1 ATOM 3029 C CE3 . TRP A 1 485 ? -6.734 -27.770 31.769 1.00 67.53 ? 458 TRP B CE3 1 ATOM 3030 C CZ2 . TRP A 1 485 ? -4.134 -27.730 30.614 1.00 63.07 ? 458 TRP B CZ2 1 ATOM 3031 C CZ3 . TRP A 1 485 ? -5.586 -27.711 32.558 1.00 67.65 ? 458 TRP B CZ3 1 ATOM 3032 C CH2 . TRP A 1 485 ? -4.308 -27.692 31.974 1.00 67.95 ? 458 TRP B CH2 1 ATOM 3033 N N . GLN A 1 486 ? -8.225 -24.726 30.352 1.00 53.83 ? 459 GLN B N 1 ATOM 3034 C CA . GLN A 1 486 ? -7.713 -23.864 31.420 1.00 50.91 ? 459 GLN B CA 1 ATOM 3035 C C . GLN A 1 486 ? -8.722 -22.815 31.786 1.00 47.34 ? 459 GLN B C 1 ATOM 3036 O O . GLN A 1 486 ? -8.801 -22.392 32.955 1.00 46.24 ? 459 GLN B O 1 ATOM 3037 C CB . GLN A 1 486 ? -6.383 -23.238 31.023 1.00 52.44 ? 459 GLN B CB 1 ATOM 3038 C CG . GLN A 1 486 ? -5.342 -24.333 30.883 1.00 55.56 ? 459 GLN B CG 1 ATOM 3039 C CD . GLN A 1 486 ? -4.065 -23.900 30.211 1.00 55.94 ? 459 GLN B CD 1 ATOM 3040 O OE1 . GLN A 1 486 ? -4.062 -23.078 29.305 1.00 54.67 ? 459 GLN B OE1 1 ATOM 3041 N NE2 . GLN A 1 486 ? -2.963 -24.476 30.654 1.00 65.21 ? 459 GLN B NE2 1 ATOM 3042 N N . VAL A 1 487 ? -9.504 -22.399 30.795 1.00 45.34 ? 460 VAL B N 1 ATOM 3043 C CA . VAL A 1 487 ? -10.572 -21.462 31.048 1.00 43.79 ? 460 VAL B CA 1 ATOM 3044 C C . VAL A 1 487 ? -11.685 -22.183 31.824 1.00 43.37 ? 460 VAL B C 1 ATOM 3045 O O . VAL A 1 487 ? -12.267 -21.609 32.758 1.00 42.48 ? 460 VAL B O 1 ATOM 3046 C CB . VAL A 1 487 ? -11.066 -20.827 29.763 1.00 44.41 ? 460 VAL B CB 1 ATOM 3047 C CG1 . VAL A 1 487 ? -12.128 -19.762 30.066 1.00 43.70 ? 460 VAL B CG1 1 ATOM 3048 C CG2 . VAL A 1 487 ? -9.895 -20.173 29.068 1.00 48.63 ? 460 VAL B CG2 1 ATOM 3049 N N . LEU A 1 488 ? -11.944 -23.440 31.474 1.00 39.03 ? 461 LEU B N 1 ATOM 3050 C CA . LEU A 1 488 ? -12.945 -24.219 32.173 1.00 43.91 ? 461 LEU B CA 1 ATOM 3051 C C . LEU A 1 488 ? -12.534 -24.197 33.634 1.00 47.57 ? 461 LEU B C 1 ATOM 3052 O O . LEU A 1 488 ? -13.310 -23.806 34.525 1.00 42.08 ? 461 LEU B O 1 ATOM 3053 C CB . LEU A 1 488 ? -12.978 -25.669 31.666 1.00 46.73 ? 461 LEU B CB 1 ATOM 3054 C CG . LEU A 1 488 ? -14.307 -26.429 31.726 1.00 47.54 ? 461 LEU B CG 1 ATOM 3055 C CD1 . LEU A 1 488 ? -14.141 -27.943 31.672 1.00 44.52 ? 461 LEU B CD1 1 ATOM 3056 C CD2 . LEU A 1 488 ? -15.143 -26.042 32.919 1.00 48.71 ? 461 LEU B CD2 1 ATOM 3057 N N . LYS A 1 489 ? -11.278 -24.577 33.864 1.00 48.18 ? 462 LYS B N 1 ATOM 3058 C CA . LYS A 1 489 ? -10.750 -24.637 35.208 1.00 49.25 ? 462 LYS B CA 1 ATOM 3059 C C . LYS A 1 489 ? -10.963 -23.326 35.930 1.00 49.76 ? 462 LYS B C 1 ATOM 3060 O O . LYS A 1 489 ? -11.443 -23.303 37.064 1.00 53.58 ? 462 LYS B O 1 ATOM 3061 C CB . LYS A 1 489 ? -9.281 -24.969 35.174 1.00 53.05 ? 462 LYS B CB 1 ATOM 3062 C CG . LYS A 1 489 ? -8.618 -24.947 36.529 1.00 56.72 ? 462 LYS B CG 1 ATOM 3063 C CD . LYS A 1 489 ? -9.210 -25.973 37.481 1.00 55.26 ? 462 LYS B CD 1 ATOM 3064 C CE . LYS A 1 489 ? -8.506 -25.859 38.820 1.00 52.99 ? 462 LYS B CE 1 ATOM 3065 N NZ . LYS A 1 489 ? -8.364 -27.190 39.385 1.00 53.55 ? 462 LYS B NZ 1 ATOM 3066 N N . HIS A 1 490 ? -10.620 -22.228 35.279 1.00 45.48 ? 463 HIS B N 1 ATOM 3067 C CA . HIS A 1 490 ? -10.819 -20.948 35.911 1.00 48.02 ? 463 HIS B CA 1 ATOM 3068 C C . HIS A 1 490 ? -12.289 -20.629 36.125 1.00 50.87 ? 463 HIS B C 1 ATOM 3069 O O . HIS A 1 490 ? -12.644 -20.022 37.128 1.00 53.40 ? 463 HIS B O 1 ATOM 3070 C CB . HIS A 1 490 ? -10.097 -19.841 35.146 1.00 51.28 ? 463 HIS B CB 1 ATOM 3071 C CG . HIS A 1 490 ? -8.696 -19.672 35.609 1.00 58.25 ? 463 HIS B CG 1 ATOM 3072 N ND1 . HIS A 1 490 ? -8.364 -18.817 36.639 1.00 54.78 ? 463 HIS B ND1 1 ATOM 3073 C CD2 . HIS A 1 490 ? -7.567 -20.352 35.287 1.00 56.32 ? 463 HIS B CD2 1 ATOM 3074 C CE1 . HIS A 1 490 ? -7.076 -18.943 36.892 1.00 56.22 ? 463 HIS B CE1 1 ATOM 3075 N NE2 . HIS A 1 490 ? -6.573 -19.875 36.096 1.00 56.38 ? 463 HIS B NE2 1 ATOM 3076 N N . LEU A 1 491 ? -13.144 -21.040 35.195 1.00 46.75 ? 464 LEU B N 1 ATOM 3077 C CA . LEU A 1 491 ? -14.549 -20.820 35.377 1.00 46.13 ? 464 LEU B CA 1 ATOM 3078 C C . LEU A 1 491 ? -15.072 -21.641 36.571 1.00 46.55 ? 464 LEU B C 1 ATOM 3079 O O . LEU A 1 491 ? -15.884 -21.159 37.306 1.00 43.77 ? 464 LEU B O 1 ATOM 3080 C CB . LEU A 1 491 ? -15.307 -21.133 34.094 1.00 46.24 ? 464 LEU B CB 1 ATOM 3081 C CG . LEU A 1 491 ? -15.234 -20.085 33.003 1.00 42.59 ? 464 LEU B CG 1 ATOM 3082 C CD1 . LEU A 1 491 ? -15.745 -20.656 31.703 1.00 40.63 ? 464 LEU B CD1 1 ATOM 3083 C CD2 . LEU A 1 491 ? -16.071 -18.891 33.391 1.00 46.49 ? 464 LEU B CD2 1 ATOM 3084 N N . ARG A 1 492 ? -14.585 -22.858 36.785 1.00 55.88 ? 465 ARG B N 1 ATOM 3085 C CA . ARG A 1 492 ? -15.011 -23.650 37.955 1.00 57.80 ? 465 ARG B CA 1 ATOM 3086 C C . ARG A 1 492 ? -14.670 -22.962 39.284 1.00 56.18 ? 465 ARG B C 1 ATOM 3087 O O . ARG A 1 492 ? -15.414 -23.127 40.247 1.00 59.78 ? 465 ARG B O 1 ATOM 3088 C CB . ARG A 1 492 ? -14.429 -25.081 37.951 1.00 61.04 ? 465 ARG B CB 1 ATOM 3089 C CG . ARG A 1 492 ? -14.681 -25.878 36.667 1.00 71.63 ? 465 ARG B CG 1 ATOM 3090 C CD . ARG A 1 492 ? -15.128 -27.342 36.882 1.00 86.12 ? 465 ARG B CD 1 ATOM 3091 N NE . ARG A 1 492 ? -14.055 -28.356 36.799 1.00 88.28 ? 465 ARG B NE 1 ATOM 3092 C CZ . ARG A 1 492 ? -13.120 -28.568 37.735 1.00 92.41 ? 465 ARG B CZ 1 ATOM 3093 N NH1 . ARG A 1 492 ? -13.064 -27.845 38.851 1.00 94.33 ? 465 ARG B NH1 1 ATOM 3094 N NH2 . ARG A 1 492 ? -12.209 -29.507 37.556 1.00 94.85 ? 465 ARG B NH2 1 ATOM 3095 N N . HIS A 1 493 ? -13.579 -22.184 39.345 1.00 54.62 ? 466 HIS B N 1 ATOM 3096 C CA . HIS A 1 493 ? -13.174 -21.497 40.609 1.00 52.40 ? 466 HIS B CA 1 ATOM 3097 C C . HIS A 1 493 ? -13.504 -20.007 40.670 1.00 45.90 ? 466 HIS B C 1 ATOM 3098 O O . HIS A 1 493 ? -13.217 -19.335 41.638 1.00 48.65 ? 466 HIS B O 1 ATOM 3099 C CB . HIS A 1 493 ? -11.686 -21.730 40.916 1.00 53.87 ? 466 HIS B CB 1 ATOM 3100 C CG . HIS A 1 493 ? -11.361 -23.155 41.261 1.00 63.18 ? 466 HIS B CG 1 ATOM 3101 N ND1 . HIS A 1 493 ? -10.902 -23.543 42.503 1.00 66.57 ? 466 HIS B ND1 1 ATOM 3102 C CD2 . HIS A 1 493 ? -11.459 -24.292 40.529 1.00 70.48 ? 466 HIS B CD2 1 ATOM 3103 C CE1 . HIS A 1 493 ? -10.724 -24.853 42.519 1.00 70.09 ? 466 HIS B CE1 1 ATOM 3104 N NE2 . HIS A 1 493 ? -11.049 -25.332 41.329 1.00 70.19 ? 466 HIS B NE2 1 ATOM 3105 N N . LEU A 1 494 ? -14.182 -19.500 39.666 1.00 48.39 ? 467 LEU B N 1 ATOM 3106 C CA . LEU A 1 494 ? -14.445 -18.090 39.551 1.00 45.38 ? 467 LEU B CA 1 ATOM 3107 C C . LEU A 1 494 ? -15.291 -17.581 40.698 1.00 48.82 ? 467 LEU B C 1 ATOM 3108 O O . LEU A 1 494 ? -16.186 -18.280 41.211 1.00 59.62 ? 467 LEU B O 1 ATOM 3109 C CB . LEU A 1 494 ? -15.132 -17.838 38.210 1.00 49.29 ? 467 LEU B CB 1 ATOM 3110 C CG . LEU A 1 494 ? -15.490 -16.403 37.802 1.00 59.80 ? 467 LEU B CG 1 ATOM 3111 C CD1 . LEU A 1 494 ? -14.245 -15.546 37.633 1.00 60.06 ? 467 LEU B CD1 1 ATOM 3112 C CD2 . LEU A 1 494 ? -16.298 -16.383 36.505 1.00 59.46 ? 467 LEU B CD2 1 ATOM 3113 N N . ASN A 1 495 ? -14.997 -16.348 41.089 1.00 52.06 ? 468 ASN B N 1 ATOM 3114 C CA . ASN A 1 495 ? -15.796 -15.577 42.055 1.00 50.83 ? 468 ASN B CA 1 ATOM 3115 C C . ASN A 1 495 ? -15.628 -14.119 41.735 1.00 53.36 ? 468 ASN B C 1 ATOM 3116 O O . ASN A 1 495 ? -14.522 -13.642 41.810 1.00 59.28 ? 468 ASN B O 1 ATOM 3117 C CB . ASN A 1 495 ? -15.272 -15.785 43.455 1.00 49.36 ? 468 ASN B CB 1 ATOM 3118 C CG . ASN A 1 495 ? -16.194 -15.221 44.526 1.00 57.73 ? 468 ASN B CG 1 ATOM 3119 O OD1 . ASN A 1 495 ? -17.034 -14.359 44.270 1.00 54.46 ? 468 ASN B OD1 1 ATOM 3120 N ND2 . ASN A 1 495 ? -16.037 -15.750 45.763 1.00 63.80 ? 468 ASN B ND2 1 ATOM 3121 N N . PHE A 1 496 ? -16.684 -13.399 41.368 1.00 52.96 ? 469 PHE B N 1 ATOM 3122 C CA . PHE A 1 496 ? -16.509 -11.979 41.061 1.00 52.07 ? 469 PHE B CA 1 ATOM 3123 C C . PHE A 1 496 ? -17.751 -11.181 41.351 1.00 54.62 ? 469 PHE B C 1 ATOM 3124 O O . PHE A 1 496 ? -18.825 -11.729 41.613 1.00 54.67 ? 469 PHE B O 1 ATOM 3125 C CB . PHE A 1 496 ? -16.043 -11.763 39.615 1.00 55.51 ? 469 PHE B CB 1 ATOM 3126 C CG . PHE A 1 496 ? -17.134 -11.872 38.593 1.00 56.90 ? 469 PHE B CG 1 ATOM 3127 C CD1 . PHE A 1 496 ? -17.377 -13.068 37.949 1.00 55.03 ? 469 PHE B CD1 1 ATOM 3128 C CD2 . PHE A 1 496 ? -17.919 -10.774 38.280 1.00 61.39 ? 469 PHE B CD2 1 ATOM 3129 C CE1 . PHE A 1 496 ? -18.400 -13.180 37.034 1.00 54.69 ? 469 PHE B CE1 1 ATOM 3130 C CE2 . PHE A 1 496 ? -18.937 -10.875 37.352 1.00 57.95 ? 469 PHE B CE2 1 ATOM 3131 C CZ . PHE A 1 496 ? -19.176 -12.081 36.735 1.00 56.82 ? 469 PHE B CZ 1 ATOM 3132 N N . THR A 1 497 ? -17.604 -9.871 41.325 1.00 55.30 ? 470 THR B N 1 ATOM 3133 C CA . THR A 1 497 ? -18.681 -9.020 41.771 1.00 60.88 ? 470 THR B CA 1 ATOM 3134 C C . THR A 1 497 ? -19.212 -8.380 40.536 1.00 58.52 ? 470 THR B C 1 ATOM 3135 O O . THR A 1 497 ? -18.451 -7.884 39.746 1.00 65.50 ? 470 THR B O 1 ATOM 3136 C CB . THR A 1 497 ? -18.173 -7.991 42.798 1.00 67.96 ? 470 THR B CB 1 ATOM 3137 O OG1 . THR A 1 497 ? -17.562 -8.704 43.886 1.00 70.00 ? 470 THR B OG1 1 ATOM 3138 C CG2 . THR A 1 497 ? -19.315 -7.136 43.346 1.00 67.97 ? 470 THR B CG2 1 ATOM 3139 N N . ASN A 1 498 ? -20.510 -8.443 40.326 1.00 61.58 ? 471 ASN B N 1 ATOM 3140 C CA . ASN A 1 498 ? -21.055 -7.924 39.085 1.00 68.86 ? 471 ASN B CA 1 ATOM 3141 C C . ASN A 1 498 ? -21.473 -6.468 39.251 1.00 70.62 ? 471 ASN B C 1 ATOM 3142 O O . ASN A 1 498 ? -21.674 -6.004 40.359 1.00 71.77 ? 471 ASN B O 1 ATOM 3143 C CB . ASN A 1 498 ? -22.180 -8.825 38.506 1.00 64.56 ? 471 ASN B CB 1 ATOM 3144 C CG . ASN A 1 498 ? -23.376 -9.028 39.438 1.00 63.45 ? 471 ASN B CG 1 ATOM 3145 O OD1 . ASN A 1 498 ? -23.689 -8.216 40.320 1.00 63.41 ? 471 ASN B OD1 1 ATOM 3146 N ND2 . ASN A 1 498 ? -24.095 -10.121 39.196 1.00 68.56 ? 471 ASN B ND2 1 ATOM 3147 N N . ASN A 1 499 ? -21.567 -5.743 38.149 1.00 77.07 ? 472 ASN B N 1 ATOM 3148 C CA . ASN A 1 499 ? -22.145 -4.406 38.169 1.00 75.56 ? 472 ASN B CA 1 ATOM 3149 C C . ASN A 1 499 ? -23.355 -4.254 39.118 1.00 67.51 ? 472 ASN B C 1 ATOM 3150 O O . ASN A 1 499 ? -23.504 -3.222 39.730 1.00 78.82 ? 472 ASN B O 1 ATOM 3151 C CB . ASN A 1 499 ? -22.520 -3.970 36.751 1.00 77.65 ? 472 ASN B CB 1 ATOM 3152 C CG . ASN A 1 499 ? -23.753 -4.680 36.235 1.00 77.19 ? 472 ASN B CG 1 ATOM 3153 O OD1 . ASN A 1 499 ? -24.740 -4.046 35.893 1.00 79.02 ? 472 ASN B OD1 1 ATOM 3154 N ND2 . ASN A 1 499 ? -23.709 -6.004 36.201 1.00 76.21 ? 472 ASN B ND2 1 ATOM 3155 N N . MET A 1 500 ? -24.198 -5.263 39.279 1.00 68.97 ? 473 MET B N 1 ATOM 3156 C CA . MET A 1 500 ? -25.306 -5.160 40.245 1.00 78.43 ? 473 MET B CA 1 ATOM 3157 C C . MET A 1 500 ? -24.811 -5.323 41.700 1.00 86.55 ? 473 MET B C 1 ATOM 3158 O O . MET A 1 500 ? -25.613 -5.283 42.643 1.00 92.55 ? 473 MET B O 1 ATOM 3159 C CB . MET A 1 500 ? -26.413 -6.211 39.977 1.00 82.70 ? 473 MET B CB 1 ATOM 3160 C CG . MET A 1 500 ? -27.026 -6.248 38.572 1.00 78.60 ? 473 MET B CG 1 ATOM 3161 S SD . MET A 1 500 ? -28.068 -4.860 38.087 1.00 85.51 ? 473 MET B SD 1 ATOM 3162 C CE . MET A 1 500 ? -29.296 -4.755 39.397 1.00 79.97 ? 473 MET B CE 1 ATOM 3163 N N . GLY A 1 501 ? -23.506 -5.527 41.884 1.00 84.28 ? 474 GLY B N 1 ATOM 3164 C CA . GLY A 1 501 ? -22.911 -5.678 43.209 1.00 86.81 ? 474 GLY B CA 1 ATOM 3165 C C . GLY A 1 501 ? -23.167 -7.033 43.839 1.00 88.39 ? 474 GLY B C 1 ATOM 3166 O O . GLY A 1 501 ? -23.271 -7.153 45.053 1.00 85.31 ? 474 GLY B O 1 ATOM 3167 N N . GLU A 1 502 ? -23.275 -8.058 43.012 1.00 89.11 ? 475 GLU B N 1 ATOM 3168 C CA . GLU A 1 502 ? -23.489 -9.403 43.508 1.00 88.04 ? 475 GLU B CA 1 ATOM 3169 C C . GLU A 1 502 ? -22.266 -10.277 43.196 1.00 79.81 ? 475 GLU B C 1 ATOM 3170 O O . GLU A 1 502 ? -21.506 -10.011 42.257 1.00 61.33 ? 475 GLU B O 1 ATOM 3171 C CB . GLU A 1 502 ? -24.755 -9.993 42.893 1.00 93.77 ? 475 GLU B CB 1 ATOM 3172 C CG . GLU A 1 502 ? -26.022 -9.193 43.172 1.00 101.75 ? 475 GLU B CG 1 ATOM 3173 C CD . GLU A 1 502 ? -27.009 -9.921 44.070 1.00 106.46 ? 475 GLU B CD 1 ATOM 3174 O OE1 . GLU A 1 502 ? -27.483 -11.004 43.677 1.00 99.25 ? 475 GLU B OE1 1 ATOM 3175 O OE2 . GLU A 1 502 ? -27.336 -9.402 45.159 1.00 121.24 ? 475 GLU B OE2 1 ATOM 3176 N N . GLN A 1 503 ? -22.069 -11.305 44.016 1.00 73.50 ? 476 GLN B N 1 ATOM 3177 C CA . GLN A 1 503 ? -21.006 -12.265 43.789 1.00 68.68 ? 476 GLN B CA 1 ATOM 3178 C C . GLN A 1 503 ? -21.499 -13.319 42.810 1.00 60.06 ? 476 GLN B C 1 ATOM 3179 O O . GLN A 1 503 ? -22.533 -13.929 42.990 1.00 56.41 ? 476 GLN B O 1 ATOM 3180 C CB . GLN A 1 503 ? -20.571 -12.936 45.105 1.00 75.80 ? 476 GLN B CB 1 ATOM 3181 C CG . GLN A 1 503 ? -19.925 -12.004 46.110 1.00 78.35 ? 476 GLN B CG 1 ATOM 3182 C CD . GLN A 1 503 ? -18.853 -11.140 45.468 1.00 83.09 ? 476 GLN B CD 1 ATOM 3183 O OE1 . GLN A 1 503 ? -17.902 -11.649 44.871 1.00 82.07 ? 476 GLN B OE1 1 ATOM 3184 N NE2 . GLN A 1 503 ? -19.016 -9.822 45.563 1.00 88.69 ? 476 GLN B NE2 1 ATOM 3185 N N . VAL A 1 504 ? -20.743 -13.545 41.769 1.00 52.69 ? 477 VAL B N 1 ATOM 3186 C CA . VAL A 1 504 ? -21.085 -14.577 40.847 1.00 49.85 ? 477 VAL B CA 1 ATOM 3187 C C . VAL A 1 504 ? -20.053 -15.683 40.975 1.00 49.53 ? 477 VAL B C 1 ATOM 3188 O O . VAL A 1 504 ? -18.880 -15.488 40.654 1.00 53.21 ? 477 VAL B O 1 ATOM 3189 C CB . VAL A 1 504 ? -21.097 -14.027 39.410 1.00 48.41 ? 477 VAL B CB 1 ATOM 3190 C CG1 . VAL A 1 504 ? -21.474 -15.134 38.445 1.00 48.93 ? 477 VAL B CG1 1 ATOM 3191 C CG2 . VAL A 1 504 ? -22.064 -12.860 39.298 1.00 46.40 ? 477 VAL B CG2 1 ATOM 3192 N N . THR A 1 505 ? -20.500 -16.832 41.451 1.00 48.37 ? 478 THR B N 1 ATOM 3193 C CA . THR A 1 505 ? -19.710 -18.045 41.487 1.00 51.79 ? 478 THR B CA 1 ATOM 3194 C C . THR A 1 505 ? -20.645 -19.153 41.005 1.00 51.59 ? 478 THR B C 1 ATOM 3195 O O . THR A 1 505 ? -21.859 -18.964 41.065 1.00 53.41 ? 478 THR B O 1 ATOM 3196 C CB . THR A 1 505 ? -19.252 -18.380 42.935 1.00 60.30 ? 478 THR B CB 1 ATOM 3197 O OG1 . THR A 1 505 ? -20.393 -18.541 43.811 1.00 53.97 ? 478 THR B OG1 1 ATOM 3198 C CG2 . THR A 1 505 ? -18.355 -17.292 43.507 1.00 58.96 ? 478 THR B CG2 1 ATOM 3199 N N . PHE A 1 506 ? -20.087 -20.295 40.573 1.00 47.74 ? 479 PHE B N 1 ATOM 3200 C CA . PHE A 1 506 ? -20.850 -21.435 40.082 1.00 45.82 ? 479 PHE B CA 1 ATOM 3201 C C . PHE A 1 506 ? -20.698 -22.611 41.014 1.00 48.44 ? 479 PHE B C 1 ATOM 3202 O O . PHE A 1 506 ? -19.623 -22.881 41.482 1.00 49.47 ? 479 PHE B O 1 ATOM 3203 C CB . PHE A 1 506 ? -20.343 -21.892 38.724 1.00 48.28 ? 479 PHE B CB 1 ATOM 3204 C CG . PHE A 1 506 ? -20.445 -20.866 37.663 1.00 50.55 ? 479 PHE B CG 1 ATOM 3205 C CD1 . PHE A 1 506 ? -21.627 -20.692 36.958 1.00 56.38 ? 479 PHE B CD1 1 ATOM 3206 C CD2 . PHE A 1 506 ? -19.365 -20.080 37.351 1.00 50.44 ? 479 PHE B CD2 1 ATOM 3207 C CE1 . PHE A 1 506 ? -21.724 -19.720 35.975 1.00 57.63 ? 479 PHE B CE1 1 ATOM 3208 C CE2 . PHE A 1 506 ? -19.454 -19.110 36.369 1.00 52.60 ? 479 PHE B CE2 1 ATOM 3209 C CZ . PHE A 1 506 ? -20.627 -18.931 35.680 1.00 53.91 ? 479 PHE B CZ 1 ATOM 3210 N N . ASP A 1 507 ? -21.759 -23.367 41.230 1.00 53.61 ? 480 ASP B N 1 ATOM 3211 C CA . ASP A 1 507 ? -21.696 -24.460 42.185 1.00 52.78 ? 480 ASP B CA 1 ATOM 3212 C C . ASP A 1 507 ? -20.970 -25.686 41.616 1.00 51.60 ? 480 ASP B C 1 ATOM 3213 O O . ASP A 1 507 ? -20.434 -25.642 40.502 1.00 47.18 ? 480 ASP B O 1 ATOM 3214 C CB . ASP A 1 507 ? -23.100 -24.774 42.757 1.00 57.96 ? 480 ASP B CB 1 ATOM 3215 C CG . ASP A 1 507 ? -24.008 -25.562 41.808 1.00 59.46 ? 480 ASP B CG 1 ATOM 3216 O OD1 . ASP A 1 507 ? -23.569 -26.094 40.760 1.00 63.93 ? 480 ASP B OD1 1 ATOM 3217 O OD2 . ASP A 1 507 ? -25.201 -25.660 42.141 1.00 64.62 ? 480 ASP B OD2 1 ATOM 3218 N N . GLU A 1 508 ? -20.940 -26.758 42.410 1.00 54.94 ? 481 GLU B N 1 ATOM 3219 C CA . GLU A 1 508 ? -20.319 -28.029 42.022 1.00 58.44 ? 481 GLU B CA 1 ATOM 3220 C C . GLU A 1 508 ? -20.871 -28.545 40.696 1.00 54.86 ? 481 GLU B C 1 ATOM 3221 O O . GLU A 1 508 ? -20.183 -29.286 40.000 1.00 64.52 ? 481 GLU B O 1 ATOM 3222 C CB . GLU A 1 508 ? -20.537 -29.100 43.127 1.00 58.55 ? 481 GLU B CB 1 HETATM 3223 N N . CSO A 1 509 ? -22.106 -28.179 40.364 1.00 54.23 ? 482 CSO B N 1 HETATM 3224 C CA . CSO A 1 509 ? -22.751 -28.593 39.103 1.00 65.24 ? 482 CSO B CA 1 HETATM 3225 C CB . CSO A 1 509 ? -24.181 -29.032 39.407 1.00 74.14 ? 482 CSO B CB 1 HETATM 3226 S SG . CSO A 1 509 ? -24.083 -30.342 40.601 1.00 80.81 ? 482 CSO B SG 1 HETATM 3227 C C . CSO A 1 509 ? -22.732 -27.564 37.991 1.00 63.47 ? 482 CSO B C 1 HETATM 3228 O O . CSO A 1 509 ? -23.206 -27.829 36.897 1.00 66.60 ? 482 CSO B O 1 HETATM 3229 O OD . CSO A 1 509 ? -24.802 -29.508 41.959 1.00 80.68 ? 482 CSO B OD 1 ATOM 3230 N N . GLY A 1 510 ? -22.148 -26.396 38.233 1.00 61.52 ? 483 GLY B N 1 ATOM 3231 C CA . GLY A 1 510 ? -22.001 -25.397 37.193 1.00 56.74 ? 483 GLY B CA 1 ATOM 3232 C C . GLY A 1 510 ? -23.232 -24.534 37.071 1.00 53.79 ? 483 GLY B C 1 ATOM 3233 O O . GLY A 1 510 ? -23.431 -23.890 36.065 1.00 52.55 ? 483 GLY B O 1 ATOM 3234 N N . ASP A 1 511 ? -24.053 -24.517 38.110 1.00 51.14 ? 484 ASP B N 1 ATOM 3235 C CA . ASP A 1 511 ? -25.296 -23.774 38.082 1.00 50.90 ? 484 ASP B CA 1 ATOM 3236 C C . ASP A 1 511 ? -25.072 -22.507 38.849 1.00 49.82 ? 484 ASP B C 1 ATOM 3237 O O . ASP A 1 511 ? -24.155 -22.403 39.626 1.00 47.00 ? 484 ASP B O 1 ATOM 3238 C CB . ASP A 1 511 ? -26.411 -24.587 38.734 1.00 52.51 ? 484 ASP B CB 1 ATOM 3239 C CG . ASP A 1 511 ? -26.668 -25.933 38.025 1.00 58.68 ? 484 ASP B CG 1 ATOM 3240 O OD1 . ASP A 1 511 ? -26.379 -26.116 36.813 1.00 73.91 ? 484 ASP B OD1 1 ATOM 3241 O OD2 . ASP A 1 511 ? -27.185 -26.828 38.684 1.00 63.12 ? 484 ASP B OD2 1 ATOM 3242 N N . LEU A 1 512 ? -25.913 -21.523 38.631 1.00 54.67 ? 485 LEU B N 1 ATOM 3243 C CA . LEU A 1 512 ? -25.806 -20.300 39.382 1.00 53.94 ? 485 LEU B CA 1 ATOM 3244 C C . LEU A 1 512 ? -27.173 -20.014 39.933 1.00 54.34 ? 485 LEU B C 1 ATOM 3245 O O . LEU A 1 512 ? -28.069 -19.702 39.185 1.00 68.11 ? 485 LEU B O 1 ATOM 3246 C CB . LEU A 1 512 ? -25.303 -19.178 38.481 1.00 56.18 ? 485 LEU B CB 1 ATOM 3247 C CG . LEU A 1 512 ? -25.531 -17.727 38.913 1.00 54.40 ? 485 LEU B CG 1 ATOM 3248 C CD1 . LEU A 1 512 ? -24.894 -17.406 40.245 1.00 61.77 ? 485 LEU B CD1 1 ATOM 3249 C CD2 . LEU A 1 512 ? -24.971 -16.804 37.862 1.00 50.84 ? 485 LEU B CD2 1 ATOM 3250 N N . VAL A 1 513 ? -27.334 -20.165 41.239 1.00 65.05 ? 486 VAL B N 1 ATOM 3251 C CA . VAL A 1 513 ? -28.606 -19.861 41.922 1.00 72.34 ? 486 VAL B CA 1 ATOM 3252 C C . VAL A 1 513 ? -29.082 -18.418 41.741 1.00 65.59 ? 486 VAL B C 1 ATOM 3253 O O . VAL A 1 513 ? -28.299 -17.477 41.537 1.00 73.47 ? 486 VAL B O 1 ATOM 3254 C CB . VAL A 1 513 ? -28.554 -20.147 43.449 1.00 81.63 ? 486 VAL B CB 1 ATOM 3255 C CG1 . VAL A 1 513 ? -28.180 -21.601 43.713 1.00 85.22 ? 486 VAL B CG1 1 ATOM 3256 C CG2 . VAL A 1 513 ? -27.605 -19.195 44.175 1.00 81.68 ? 486 VAL B CG2 1 ATOM 3257 N N . GLY A 1 514 ? -30.389 -18.276 41.842 1.00 61.06 ? 487 GLY B N 1 ATOM 3258 C CA . GLY A 1 514 ? -31.089 -17.067 41.452 1.00 61.99 ? 487 GLY B CA 1 ATOM 3259 C C . GLY A 1 514 ? -32.471 -17.143 42.057 1.00 63.47 ? 487 GLY B C 1 ATOM 3260 O O . GLY A 1 514 ? -32.910 -18.212 42.491 1.00 57.98 ? 487 GLY B O 1 ATOM 3261 N N . ASN A 1 515 ? -33.143 -16.000 42.123 1.00 70.37 ? 488 ASN B N 1 ATOM 3262 C CA . ASN A 1 515 ? -34.529 -15.949 42.566 1.00 68.93 ? 488 ASN B CA 1 ATOM 3263 C C . ASN A 1 515 ? -35.423 -15.741 41.364 1.00 64.46 ? 488 ASN B C 1 ATOM 3264 O O . ASN A 1 515 ? -34.928 -15.576 40.244 1.00 69.36 ? 488 ASN B O 1 ATOM 3265 C CB . ASN A 1 515 ? -34.714 -14.818 43.545 1.00 72.83 ? 488 ASN B CB 1 ATOM 3266 C CG . ASN A 1 515 ? -34.008 -15.058 44.866 1.00 79.12 ? 488 ASN B CG 1 ATOM 3267 O OD1 . ASN A 1 515 ? -33.945 -16.187 45.379 1.00 63.47 ? 488 ASN B OD1 1 ATOM 3268 N ND2 . ASN A 1 515 ? -33.485 -13.955 45.431 1.00 92.68 ? 488 ASN B ND2 1 ATOM 3269 N N . TYR A 1 516 ? -36.732 -15.771 41.583 1.00 60.84 ? 489 TYR B N 1 ATOM 3270 C CA . TYR A 1 516 ? -37.706 -15.593 40.490 1.00 59.32 ? 489 TYR B CA 1 ATOM 3271 C C . TYR A 1 516 ? -38.640 -14.409 40.777 1.00 58.28 ? 489 TYR B C 1 ATOM 3272 O O . TYR A 1 516 ? -39.061 -14.177 41.918 1.00 48.56 ? 489 TYR B O 1 ATOM 3273 C CB . TYR A 1 516 ? -38.564 -16.855 40.270 1.00 55.50 ? 489 TYR B CB 1 ATOM 3274 C CG . TYR A 1 516 ? -37.824 -18.106 39.843 1.00 56.46 ? 489 TYR B CG 1 ATOM 3275 C CD1 . TYR A 1 516 ? -37.183 -18.172 38.613 1.00 54.98 ? 489 TYR B CD1 1 ATOM 3276 C CD2 . TYR A 1 516 ? -37.785 -19.232 40.656 1.00 58.34 ? 489 TYR B CD2 1 ATOM 3277 C CE1 . TYR A 1 516 ? -36.510 -19.307 38.218 1.00 53.10 ? 489 TYR B CE1 1 ATOM 3278 C CE2 . TYR A 1 516 ? -37.110 -20.384 40.256 1.00 59.44 ? 489 TYR B CE2 1 ATOM 3279 C CZ . TYR A 1 516 ? -36.480 -20.410 39.030 1.00 55.47 ? 489 TYR B CZ 1 ATOM 3280 O OH . TYR A 1 516 ? -35.807 -21.531 38.612 1.00 53.90 ? 489 TYR B OH 1 ATOM 3281 N N . SER A 1 517 ? -38.932 -13.649 39.733 1.00 54.88 ? 490 SER B N 1 ATOM 3282 C CA . SER A 1 517 ? -40.029 -12.727 39.774 1.00 53.60 ? 490 SER B CA 1 ATOM 3283 C C . SER A 1 517 ? -41.303 -13.480 39.384 1.00 55.79 ? 490 SER B C 1 ATOM 3284 O O . SER A 1 517 ? -41.259 -14.442 38.621 1.00 54.08 ? 490 SER B O 1 ATOM 3285 C CB . SER A 1 517 ? -39.785 -11.574 38.824 1.00 51.83 ? 490 SER B CB 1 ATOM 3286 O OG . SER A 1 517 ? -38.966 -10.643 39.475 1.00 58.41 ? 490 SER B OG 1 ATOM 3287 N N . ILE A 1 518 ? -42.434 -13.036 39.923 1.00 50.63 ? 491 ILE B N 1 ATOM 3288 C CA . ILE A 1 518 ? -43.703 -13.548 39.524 1.00 47.08 ? 491 ILE B CA 1 ATOM 3289 C C . ILE A 1 518 ? -44.495 -12.467 38.851 1.00 50.39 ? 491 ILE B C 1 ATOM 3290 O O . ILE A 1 518 ? -44.751 -11.423 39.463 1.00 54.56 ? 491 ILE B O 1 ATOM 3291 C CB . ILE A 1 518 ? -44.471 -14.068 40.707 1.00 46.57 ? 491 ILE B CB 1 ATOM 3292 C CG1 . ILE A 1 518 ? -43.602 -15.092 41.429 1.00 50.31 ? 491 ILE B CG1 1 ATOM 3293 C CG2 . ILE A 1 518 ? -45.764 -14.698 40.208 1.00 44.55 ? 491 ILE B CG2 1 ATOM 3294 C CD1 . ILE A 1 518 ? -44.230 -15.659 42.679 1.00 54.86 ? 491 ILE B CD1 1 ATOM 3295 N N . ILE A 1 519 ? -44.877 -12.718 37.596 1.00 47.85 ? 492 ILE B N 1 ATOM 3296 C CA . ILE A 1 519 ? -45.539 -11.710 36.789 1.00 49.90 ? 492 ILE B CA 1 ATOM 3297 C C . ILE A 1 519 ? -46.955 -12.127 36.447 1.00 53.21 ? 492 ILE B C 1 ATOM 3298 O O . ILE A 1 519 ? -47.274 -13.320 36.416 1.00 59.19 ? 492 ILE B O 1 ATOM 3299 C CB . ILE A 1 519 ? -44.793 -11.420 35.488 1.00 52.21 ? 492 ILE B CB 1 ATOM 3300 C CG1 . ILE A 1 519 ? -44.540 -12.714 34.680 1.00 58.24 ? 492 ILE B CG1 1 ATOM 3301 C CG2 . ILE A 1 519 ? -43.497 -10.714 35.790 1.00 48.57 ? 492 ILE B CG2 1 ATOM 3302 C CD1 . ILE A 1 519 ? -44.221 -12.479 33.210 1.00 55.47 ? 492 ILE B CD1 1 ATOM 3303 N N . ASN A 1 520 ? -47.813 -11.142 36.198 1.00 52.37 ? 493 ASN B N 1 ATOM 3304 C CA . ASN A 1 520 ? -49.192 -11.422 35.813 1.00 53.16 ? 493 ASN B CA 1 ATOM 3305 C C . ASN A 1 520 ? -49.467 -10.671 34.551 1.00 49.70 ? 493 ASN B C 1 ATOM 3306 O O . ASN A 1 520 ? -48.952 -9.584 34.396 1.00 58.71 ? 493 ASN B O 1 ATOM 3307 C CB . ASN A 1 520 ? -50.117 -10.990 36.929 1.00 57.06 ? 493 ASN B CB 1 ATOM 3308 C CG . ASN A 1 520 ? -51.543 -11.411 36.720 1.00 62.15 ? 493 ASN B CG 1 ATOM 3309 O OD1 . ASN A 1 520 ? -51.871 -12.301 35.933 1.00 73.55 ? 493 ASN B OD1 1 ATOM 3310 N ND2 . ASN A 1 520 ? -52.408 -10.782 37.463 1.00 64.43 ? 493 ASN B ND2 1 ATOM 3311 N N . TRP A 1 521 ? -50.217 -11.270 33.635 1.00 50.27 ? 494 TRP B N 1 ATOM 3312 C CA . TRP A 1 521 ? -50.510 -10.656 32.325 1.00 55.34 ? 494 TRP B CA 1 ATOM 3313 C C . TRP A 1 521 ? -51.733 -9.695 32.345 1.00 58.17 ? 494 TRP B C 1 ATOM 3314 O O . TRP A 1 521 ? -52.880 -10.140 32.460 1.00 57.54 ? 494 TRP B O 1 ATOM 3315 C CB . TRP A 1 521 ? -50.768 -11.765 31.308 1.00 56.72 ? 494 TRP B CB 1 ATOM 3316 C CG . TRP A 1 521 ? -49.549 -12.537 30.880 1.00 52.00 ? 494 TRP B CG 1 ATOM 3317 C CD1 . TRP A 1 521 ? -48.378 -12.621 31.528 1.00 51.57 ? 494 TRP B CD1 1 ATOM 3318 C CD2 . TRP A 1 521 ? -49.431 -13.362 29.721 1.00 47.17 ? 494 TRP B CD2 1 ATOM 3319 N NE1 . TRP A 1 521 ? -47.507 -13.408 30.829 1.00 49.99 ? 494 TRP B NE1 1 ATOM 3320 C CE2 . TRP A 1 521 ? -48.135 -13.883 29.718 1.00 48.04 ? 494 TRP B CE2 1 ATOM 3321 C CE3 . TRP A 1 521 ? -50.297 -13.697 28.678 1.00 50.66 ? 494 TRP B CE3 1 ATOM 3322 C CZ2 . TRP A 1 521 ? -47.666 -14.733 28.716 1.00 50.91 ? 494 TRP B CZ2 1 ATOM 3323 C CZ3 . TRP A 1 521 ? -49.833 -14.533 27.671 1.00 55.16 ? 494 TRP B CZ3 1 ATOM 3324 C CH2 . TRP A 1 521 ? -48.522 -15.033 27.691 1.00 52.02 ? 494 TRP B CH2 1 ATOM 3325 N N . HIS A 1 522 ? -51.479 -8.389 32.260 1.00 62.67 ? 495 HIS B N 1 ATOM 3326 C CA . HIS A 1 522 ? -52.554 -7.366 32.177 1.00 66.00 ? 495 HIS B CA 1 ATOM 3327 C C . HIS A 1 522 ? -52.626 -6.772 30.785 1.00 65.12 ? 495 HIS B C 1 ATOM 3328 O O . HIS A 1 522 ? -51.718 -6.962 29.978 1.00 65.36 ? 495 HIS B O 1 ATOM 3329 C CB . HIS A 1 522 ? -52.317 -6.189 33.123 1.00 60.84 ? 495 HIS B CB 1 ATOM 3330 C CG . HIS A 1 522 ? -52.282 -6.544 34.571 1.00 57.80 ? 495 HIS B CG 1 ATOM 3331 N ND1 . HIS A 1 522 ? -52.686 -7.761 35.061 1.00 63.92 ? 495 HIS B ND1 1 ATOM 3332 C CD2 . HIS A 1 522 ? -51.903 -5.815 35.646 1.00 65.66 ? 495 HIS B CD2 1 ATOM 3333 C CE1 . HIS A 1 522 ? -52.555 -7.770 36.377 1.00 65.81 ? 495 HIS B CE1 1 ATOM 3334 N NE2 . HIS A 1 522 ? -52.079 -6.602 36.757 1.00 65.20 ? 495 HIS B NE2 1 ATOM 3335 N N . LEU A 1 523 ? -53.699 -6.025 30.528 1.00 73.94 ? 496 LEU B N 1 ATOM 3336 C CA . LEU A 1 523 ? -53.870 -5.298 29.263 1.00 75.41 ? 496 LEU B CA 1 ATOM 3337 C C . LEU A 1 523 ? -53.629 -3.830 29.512 1.00 76.11 ? 496 LEU B C 1 ATOM 3338 O O . LEU A 1 523 ? -54.219 -3.263 30.414 1.00 72.86 ? 496 LEU B O 1 ATOM 3339 C CB . LEU A 1 523 ? -55.276 -5.478 28.716 1.00 71.79 ? 496 LEU B CB 1 ATOM 3340 C CG . LEU A 1 523 ? -55.296 -6.101 27.328 1.00 81.67 ? 496 LEU B CG 1 ATOM 3341 C CD1 . LEU A 1 523 ? -56.719 -6.351 26.857 1.00 84.56 ? 496 LEU B CD1 1 ATOM 3342 C CD2 . LEU A 1 523 ? -54.565 -5.225 26.335 1.00 87.19 ? 496 LEU B CD2 1 ATOM 3343 N N . SER A 1 524 ? -52.740 -3.223 28.742 1.00 82.58 ? 497 SER B N 1 ATOM 3344 C CA . SER A 1 524 ? -52.543 -1.777 28.816 1.00 93.48 ? 497 SER B CA 1 ATOM 3345 C C . SER A 1 524 ? -53.825 -1.097 28.305 1.00 92.33 ? 497 SER B C 1 ATOM 3346 O O . SER A 1 524 ? -54.287 -1.412 27.210 1.00 87.07 ? 497 SER B O 1 ATOM 3347 C CB . SER A 1 524 ? -51.332 -1.349 27.969 1.00 94.13 ? 497 SER B CB 1 ATOM 3348 O OG . SER A 1 524 ? -50.847 -0.074 28.353 1.00 90.94 ? 497 SER B OG 1 ATOM 3349 N N . PRO A 1 525 ? -54.424 -0.198 29.108 1.00 97.11 ? 498 PRO B N 1 ATOM 3350 C CA . PRO A 1 525 ? -55.527 0.607 28.585 1.00 105.34 ? 498 PRO B CA 1 ATOM 3351 C C . PRO A 1 525 ? -55.021 1.725 27.638 1.00 110.58 ? 498 PRO B C 1 ATOM 3352 O O . PRO A 1 525 ? -55.755 2.159 26.738 1.00 102.09 ? 498 PRO B O 1 ATOM 3353 C CB . PRO A 1 525 ? -56.165 1.182 29.852 1.00 100.01 ? 498 PRO B CB 1 ATOM 3354 C CG . PRO A 1 525 ? -55.031 1.295 30.818 1.00 100.21 ? 498 PRO B CG 1 ATOM 3355 C CD . PRO A 1 525 ? -54.104 0.153 30.508 1.00 102.42 ? 498 PRO B CD 1 ATOM 3356 N N . GLU A 1 526 ? -53.775 2.166 27.850 1.00 109.53 ? 499 GLU B N 1 ATOM 3357 C CA . GLU A 1 526 ? -53.110 3.133 26.977 1.00 105.42 ? 499 GLU B CA 1 ATOM 3358 C C . GLU A 1 526 ? -52.815 2.525 25.605 1.00 111.21 ? 499 GLU B C 1 ATOM 3359 O O . GLU A 1 526 ? -53.126 3.126 24.583 1.00 125.60 ? 499 GLU B O 1 ATOM 3360 C CB . GLU A 1 526 ? -51.805 3.634 27.623 1.00 93.22 ? 499 GLU B CB 1 ATOM 3361 N N . ASP A 1 527 ? -52.232 1.326 25.593 1.00 115.23 ? 500 ASP B N 1 ATOM 3362 C CA . ASP A 1 527 ? -51.714 0.706 24.366 1.00 107.67 ? 500 ASP B CA 1 ATOM 3363 C C . ASP A 1 527 ? -52.655 -0.346 23.740 1.00 101.91 ? 500 ASP B C 1 ATOM 3364 O O . ASP A 1 527 ? -52.612 -0.586 22.531 1.00 98.58 ? 500 ASP B O 1 ATOM 3365 C CB . ASP A 1 527 ? -50.350 0.066 24.675 1.00 103.70 ? 500 ASP B CB 1 ATOM 3366 C CG . ASP A 1 527 ? -49.417 0.035 23.473 1.00 97.99 ? 500 ASP B CG 1 ATOM 3367 O OD1 . ASP A 1 527 ? -49.886 0.010 22.310 1.00 87.80 ? 500 ASP B OD1 1 ATOM 3368 O OD2 . ASP A 1 527 ? -48.190 0.028 23.711 1.00 98.50 ? 500 ASP B OD2 1 ATOM 3369 N N . GLY A 1 528 ? -53.495 -0.977 24.553 1.00 94.02 ? 501 GLY B N 1 ATOM 3370 C CA . GLY A 1 528 ? -54.220 -2.170 24.116 1.00 88.07 ? 501 GLY B CA 1 ATOM 3371 C C . GLY A 1 528 ? -53.341 -3.424 24.082 1.00 87.74 ? 501 GLY B C 1 ATOM 3372 O O . GLY A 1 528 ? -53.796 -4.492 23.668 1.00 92.34 ? 501 GLY B O 1 ATOM 3373 N N . SER A 1 529 ? -52.090 -3.314 24.532 1.00 82.20 ? 502 SER B N 1 ATOM 3374 C CA . SER A 1 529 ? -51.137 -4.418 24.479 1.00 79.07 ? 502 SER B CA 1 ATOM 3375 C C . SER A 1 529 ? -50.961 -5.021 25.870 1.00 78.97 ? 502 SER B C 1 ATOM 3376 O O . SER A 1 529 ? -51.296 -4.404 26.887 1.00 80.65 ? 502 SER B O 1 ATOM 3377 C CB . SER A 1 529 ? -49.778 -3.946 23.958 1.00 80.80 ? 502 SER B CB 1 ATOM 3378 O OG . SER A 1 529 ? -49.027 -3.302 24.982 1.00 87.28 ? 502 SER B OG 1 ATOM 3379 N N . ILE A 1 530 ? -50.411 -6.229 25.901 1.00 72.93 ? 503 ILE B N 1 ATOM 3380 C CA . ILE A 1 530 ? -50.239 -6.980 27.139 1.00 71.10 ? 503 ILE B CA 1 ATOM 3381 C C . ILE A 1 530 ? -49.046 -6.477 27.947 1.00 62.24 ? 503 ILE B C 1 ATOM 3382 O O . ILE A 1 530 ? -48.022 -6.090 27.406 1.00 64.69 ? 503 ILE B O 1 ATOM 3383 C CB . ILE A 1 530 ? -50.119 -8.488 26.846 1.00 75.38 ? 503 ILE B CB 1 ATOM 3384 C CG1 . ILE A 1 530 ? -51.442 -8.999 26.277 1.00 74.77 ? 503 ILE B CG1 1 ATOM 3385 C CG2 . ILE A 1 530 ? -49.798 -9.275 28.106 1.00 77.79 ? 503 ILE B CG2 1 ATOM 3386 C CD1 . ILE A 1 530 ? -51.293 -10.223 25.415 1.00 77.87 ? 503 ILE B CD1 1 ATOM 3387 N N . VAL A 1 531 ? -49.207 -6.471 29.257 1.00 58.45 ? 504 VAL B N 1 ATOM 3388 C CA . VAL A 1 531 ? -48.245 -5.871 30.162 1.00 58.81 ? 504 VAL B CA 1 ATOM 3389 C C . VAL A 1 531 ? -47.885 -6.885 31.245 1.00 60.10 ? 504 VAL B C 1 ATOM 3390 O O . VAL A 1 531 ? -48.764 -7.392 31.960 1.00 58.60 ? 504 VAL B O 1 ATOM 3391 C CB . VAL A 1 531 ? -48.883 -4.653 30.839 1.00 59.35 ? 504 VAL B CB 1 ATOM 3392 C CG1 . VAL A 1 531 ? -47.893 -3.950 31.753 1.00 60.69 ? 504 VAL B CG1 1 ATOM 3393 C CG2 . VAL A 1 531 ? -49.432 -3.707 29.793 1.00 63.46 ? 504 VAL B CG2 1 ATOM 3394 N N . PHE A 1 532 ? -46.606 -7.163 31.400 1.00 56.10 ? 505 PHE B N 1 ATOM 3395 C CA . PHE A 1 532 ? -46.199 -8.140 32.385 1.00 58.22 ? 505 PHE B CA 1 ATOM 3396 C C . PHE A 1 532 ? -46.037 -7.472 33.735 1.00 54.54 ? 505 PHE B C 1 ATOM 3397 O O . PHE A 1 532 ? -44.951 -7.040 34.086 1.00 55.56 ? 505 PHE B O 1 ATOM 3398 C CB . PHE A 1 532 ? -44.912 -8.859 31.940 1.00 60.38 ? 505 PHE B CB 1 ATOM 3399 C CG . PHE A 1 532 ? -45.031 -9.491 30.590 1.00 61.18 ? 505 PHE B CG 1 ATOM 3400 C CD1 . PHE A 1 532 ? -46.140 -10.258 30.278 1.00 57.28 ? 505 PHE B CD1 1 ATOM 3401 C CD2 . PHE A 1 532 ? -44.067 -9.277 29.613 1.00 62.27 ? 505 PHE B CD2 1 ATOM 3402 C CE1 . PHE A 1 532 ? -46.264 -10.828 29.028 1.00 60.52 ? 505 PHE B CE1 1 ATOM 3403 C CE2 . PHE A 1 532 ? -44.189 -9.849 28.354 1.00 59.97 ? 505 PHE B CE2 1 ATOM 3404 C CZ . PHE A 1 532 ? -45.289 -10.615 28.058 1.00 57.80 ? 505 PHE B CZ 1 ATOM 3405 N N . LYS A 1 533 ? -47.120 -7.431 34.499 1.00 53.73 ? 506 LYS B N 1 ATOM 3406 C CA . LYS A 1 533 ? -47.143 -6.760 35.790 1.00 57.22 ? 506 LYS B CA 1 ATOM 3407 C C . LYS A 1 533 ? -46.414 -7.669 36.766 1.00 51.62 ? 506 LYS B C 1 ATOM 3408 O O . LYS A 1 533 ? -46.737 -8.848 36.815 1.00 48.62 ? 506 LYS B O 1 ATOM 3409 C CB . LYS A 1 533 ? -48.615 -6.515 36.223 1.00 64.28 ? 506 LYS B CB 1 ATOM 3410 C CG . LYS A 1 533 ? -48.876 -5.255 37.045 1.00 76.73 ? 506 LYS B CG 1 ATOM 3411 C CD . LYS A 1 533 ? -47.943 -5.167 38.254 1.00 94.33 ? 506 LYS B CD 1 ATOM 3412 C CE . LYS A 1 533 ? -48.340 -4.091 39.262 1.00 103.15 ? 506 LYS B CE 1 ATOM 3413 N NZ . LYS A 1 533 ? -48.597 -2.762 38.632 1.00 101.87 ? 506 LYS B NZ 1 ATOM 3414 N N . GLU A 1 534 ? -45.415 -7.142 37.494 1.00 55.90 ? 507 GLU B N 1 ATOM 3415 C CA . GLU A 1 534 ? -44.767 -7.871 38.626 1.00 60.82 ? 507 GLU B CA 1 ATOM 3416 C C . GLU A 1 534 ? -45.694 -7.862 39.855 1.00 55.85 ? 507 GLU B C 1 ATOM 3417 O O . GLU A 1 534 ? -46.159 -6.800 40.290 1.00 57.72 ? 507 GLU B O 1 ATOM 3418 C CB . GLU A 1 534 ? -43.370 -7.299 38.990 1.00 65.76 ? 507 GLU B CB 1 ATOM 3419 C CG . GLU A 1 534 ? -42.295 -7.461 37.891 1.00 80.43 ? 507 GLU B CG 1 ATOM 3420 C CD . GLU A 1 534 ? -40.816 -7.312 38.351 1.00 91.87 ? 507 GLU B CD 1 ATOM 3421 O OE1 . GLU A 1 534 ? -40.429 -6.240 38.886 1.00 101.63 ? 507 GLU B OE1 1 ATOM 3422 O OE2 . GLU A 1 534 ? -40.007 -8.254 38.129 1.00 79.14 ? 507 GLU B OE2 1 ATOM 3423 N N . VAL A 1 535 ? -45.983 -9.044 40.391 1.00 52.91 ? 508 VAL B N 1 ATOM 3424 C CA . VAL A 1 535 ? -46.931 -9.173 41.504 1.00 52.88 ? 508 VAL B CA 1 ATOM 3425 C C . VAL A 1 535 ? -46.399 -9.974 42.702 1.00 51.78 ? 508 VAL B C 1 ATOM 3426 O O . VAL A 1 535 ? -47.155 -10.314 43.608 1.00 51.55 ? 508 VAL B O 1 ATOM 3427 C CB . VAL A 1 535 ? -48.269 -9.797 41.037 1.00 56.72 ? 508 VAL B CB 1 ATOM 3428 C CG1 . VAL A 1 535 ? -48.827 -9.043 39.839 1.00 58.01 ? 508 VAL B CG1 1 ATOM 3429 C CG2 . VAL A 1 535 ? -48.112 -11.267 40.694 1.00 55.49 ? 508 VAL B CG2 1 ATOM 3430 N N . GLY A 1 536 ? -45.100 -10.263 42.721 1.00 53.57 ? 509 GLY B N 1 ATOM 3431 C CA . GLY A 1 536 ? -44.485 -11.017 43.830 1.00 50.18 ? 509 GLY B CA 1 ATOM 3432 C C . GLY A 1 536 ? -43.120 -11.566 43.452 1.00 49.93 ? 509 GLY B C 1 ATOM 3433 O O . GLY A 1 536 ? -42.590 -11.258 42.416 1.00 48.28 ? 509 GLY B O 1 ATOM 3434 N N . TYR A 1 537 ? -42.534 -12.386 44.298 1.00 51.98 ? 510 TYR B N 1 ATOM 3435 C CA . TYR A 1 537 ? -41.260 -12.977 43.968 1.00 49.68 ? 510 TYR B CA 1 ATOM 3436 C C . TYR A 1 537 ? -41.151 -14.249 44.741 1.00 45.26 ? 510 TYR B C 1 ATOM 3437 O O . TYR A 1 537 ? -41.899 -14.431 45.677 1.00 46.06 ? 510 TYR B O 1 ATOM 3438 C CB . TYR A 1 537 ? -40.092 -12.016 44.285 1.00 55.72 ? 510 TYR B CB 1 ATOM 3439 C CG . TYR A 1 537 ? -40.016 -11.523 45.710 1.00 58.46 ? 510 TYR B CG 1 ATOM 3440 C CD1 . TYR A 1 537 ? -40.703 -10.370 46.096 1.00 60.10 ? 510 TYR B CD1 1 ATOM 3441 C CD2 . TYR A 1 537 ? -39.235 -12.186 46.677 1.00 63.54 ? 510 TYR B CD2 1 ATOM 3442 C CE1 . TYR A 1 537 ? -40.640 -9.894 47.390 1.00 60.86 ? 510 TYR B CE1 1 ATOM 3443 C CE2 . TYR A 1 537 ? -39.168 -11.710 47.989 1.00 65.72 ? 510 TYR B CE2 1 ATOM 3444 C CZ . TYR A 1 537 ? -39.882 -10.558 48.331 1.00 63.19 ? 510 TYR B CZ 1 ATOM 3445 O OH . TYR A 1 537 ? -39.869 -10.050 49.600 1.00 63.00 ? 510 TYR B OH 1 ATOM 3446 N N . TYR A 1 538 ? -40.250 -15.130 44.322 1.00 45.38 ? 511 TYR B N 1 ATOM 3447 C CA . TYR A 1 538 ? -39.935 -16.365 45.040 1.00 51.02 ? 511 TYR B CA 1 ATOM 3448 C C . TYR A 1 538 ? -38.460 -16.417 45.418 1.00 54.17 ? 511 TYR B C 1 ATOM 3449 O O . TYR A 1 538 ? -37.607 -16.391 44.535 1.00 54.50 ? 511 TYR B O 1 ATOM 3450 C CB . TYR A 1 538 ? -40.234 -17.538 44.135 1.00 49.65 ? 511 TYR B CB 1 ATOM 3451 C CG . TYR A 1 538 ? -40.192 -18.892 44.794 1.00 46.60 ? 511 TYR B CG 1 ATOM 3452 C CD1 . TYR A 1 538 ? -41.222 -19.314 45.587 1.00 44.76 ? 511 TYR B CD1 1 ATOM 3453 C CD2 . TYR A 1 538 ? -39.150 -19.779 44.544 1.00 46.61 ? 511 TYR B CD2 1 ATOM 3454 C CE1 . TYR A 1 538 ? -41.198 -20.562 46.164 1.00 47.45 ? 511 TYR B CE1 1 ATOM 3455 C CE2 . TYR A 1 538 ? -39.121 -21.034 45.111 1.00 43.42 ? 511 TYR B CE2 1 ATOM 3456 C CZ . TYR A 1 538 ? -40.148 -21.412 45.922 1.00 42.79 ? 511 TYR B CZ 1 ATOM 3457 O OH . TYR A 1 538 ? -40.147 -22.643 46.489 1.00 42.20 ? 511 TYR B OH 1 ATOM 3458 N N . ASN A 1 539 ? -38.166 -16.472 46.718 1.00 60.57 ? 512 ASN B N 1 ATOM 3459 C CA . ASN A 1 539 ? -36.781 -16.526 47.223 1.00 58.27 ? 512 ASN B CA 1 ATOM 3460 C C . ASN A 1 539 ? -36.463 -17.980 47.427 1.00 59.86 ? 512 ASN B C 1 ATOM 3461 O O . ASN A 1 539 ? -37.035 -18.639 48.321 1.00 65.57 ? 512 ASN B O 1 ATOM 3462 C CB . ASN A 1 539 ? -36.628 -15.784 48.560 1.00 65.56 ? 512 ASN B CB 1 ATOM 3463 C CG . ASN A 1 539 ? -36.450 -14.266 48.402 1.00 71.15 ? 512 ASN B CG 1 ATOM 3464 O OD1 . ASN A 1 539 ? -36.414 -13.716 47.290 1.00 71.25 ? 512 ASN B OD1 1 ATOM 3465 N ND2 . ASN A 1 539 ? -36.332 -13.583 49.543 1.00 75.68 ? 512 ASN B ND2 1 ATOM 3466 N N . VAL A 1 540 ? -35.564 -18.498 46.596 1.00 58.47 ? 513 VAL B N 1 ATOM 3467 C CA . VAL A 1 540 ? -35.410 -19.948 46.467 1.00 54.86 ? 513 VAL B CA 1 ATOM 3468 C C . VAL A 1 540 ? -34.882 -20.625 47.715 1.00 58.39 ? 513 VAL B C 1 ATOM 3469 O O . VAL A 1 540 ? -35.304 -21.737 48.051 1.00 52.94 ? 513 VAL B O 1 ATOM 3470 C CB . VAL A 1 540 ? -34.492 -20.289 45.307 1.00 56.68 ? 513 VAL B CB 1 ATOM 3471 C CG1 . VAL A 1 540 ? -34.225 -21.794 45.242 1.00 55.66 ? 513 VAL B CG1 1 ATOM 3472 C CG2 . VAL A 1 540 ? -35.127 -19.782 44.018 1.00 60.43 ? 513 VAL B CG2 1 ATOM 3473 N N . TYR A 1 541 ? -33.972 -19.947 48.409 1.00 72.44 ? 514 TYR B N 1 ATOM 3474 C CA . TYR A 1 541 ? -33.344 -20.499 49.622 1.00 81.55 ? 514 TYR B CA 1 ATOM 3475 C C . TYR A 1 541 ? -33.847 -19.816 50.905 1.00 87.26 ? 514 TYR B C 1 ATOM 3476 O O . TYR A 1 541 ? -33.349 -18.773 51.342 1.00 95.95 ? 514 TYR B O 1 ATOM 3477 C CB . TYR A 1 541 ? -31.822 -20.448 49.479 1.00 81.49 ? 514 TYR B CB 1 ATOM 3478 C CG . TYR A 1 541 ? -31.319 -21.441 48.441 1.00 79.90 ? 514 TYR B CG 1 ATOM 3479 C CD1 . TYR A 1 541 ? -30.942 -21.030 47.165 1.00 79.41 ? 514 TYR B CD1 1 ATOM 3480 C CD2 . TYR A 1 541 ? -31.274 -22.800 48.729 1.00 84.19 ? 514 TYR B CD2 1 ATOM 3481 C CE1 . TYR A 1 541 ? -30.505 -21.944 46.219 1.00 82.64 ? 514 TYR B CE1 1 ATOM 3482 C CE2 . TYR A 1 541 ? -30.838 -23.720 47.796 1.00 86.36 ? 514 TYR B CE2 1 ATOM 3483 C CZ . TYR A 1 541 ? -30.447 -23.290 46.546 1.00 87.09 ? 514 TYR B CZ 1 ATOM 3484 O OH . TYR A 1 541 ? -30.015 -24.227 45.630 1.00 93.81 ? 514 TYR B OH 1 ATOM 3485 N N . ALA A 1 542 ? -34.863 -20.428 51.489 1.00 80.36 ? 515 ALA B N 1 ATOM 3486 C CA . ALA A 1 542 ? -35.557 -19.856 52.594 1.00 81.52 ? 515 ALA B CA 1 ATOM 3487 C C . ALA A 1 542 ? -36.453 -20.951 53.139 1.00 90.93 ? 515 ALA B C 1 ATOM 3488 O O . ALA A 1 542 ? -36.825 -21.898 52.407 1.00 82.01 ? 515 ALA B O 1 ATOM 3489 C CB . ALA A 1 542 ? -36.370 -18.666 52.126 1.00 87.13 ? 515 ALA B CB 1 ATOM 3490 N N . LYS A 1 543 ? -36.793 -20.818 54.420 1.00 98.31 ? 516 LYS B N 1 ATOM 3491 C CA . LYS A 1 543 ? -37.531 -21.854 55.147 1.00 102.39 ? 516 LYS B CA 1 ATOM 3492 C C . LYS A 1 543 ? -38.958 -21.998 54.618 1.00 97.26 ? 516 LYS B C 1 ATOM 3493 O O . LYS A 1 543 ? -39.691 -21.008 54.536 1.00 96.05 ? 516 LYS B O 1 ATOM 3494 C CB . LYS A 1 543 ? -37.543 -21.538 56.649 1.00 103.67 ? 516 LYS B CB 1 ATOM 3495 N N . LYS A 1 544 ? -39.332 -23.231 54.260 1.00 97.70 ? 517 LYS B N 1 ATOM 3496 C CA . LYS A 1 544 ? -40.649 -23.541 53.672 1.00 106.16 ? 517 LYS B CA 1 ATOM 3497 C C . LYS A 1 544 ? -41.774 -22.731 54.308 1.00 103.17 ? 517 LYS B C 1 ATOM 3498 O O . LYS A 1 544 ? -42.011 -22.829 55.506 1.00 106.69 ? 517 LYS B O 1 ATOM 3499 C CB . LYS A 1 544 ? -40.963 -25.041 53.805 1.00 108.20 ? 517 LYS B CB 1 ATOM 3500 N N . GLY A 1 545 ? -42.463 -21.930 53.503 1.00 105.29 ? 518 GLY B N 1 ATOM 3501 C CA . GLY A 1 545 ? -43.488 -21.025 54.027 1.00 96.06 ? 518 GLY B CA 1 ATOM 3502 C C . GLY A 1 545 ? -42.997 -19.598 54.172 1.00 88.86 ? 518 GLY B C 1 ATOM 3503 O O . GLY A 1 545 ? -43.786 -18.703 54.440 1.00 92.21 ? 518 GLY B O 1 ATOM 3504 N N . GLU A 1 546 ? -41.699 -19.370 53.997 1.00 84.72 ? 519 GLU B N 1 ATOM 3505 C CA . GLU A 1 546 ? -41.173 -18.012 53.940 1.00 79.01 ? 519 GLU B CA 1 ATOM 3506 C C . GLU A 1 546 ? -40.418 -17.760 52.619 1.00 80.99 ? 519 GLU B C 1 ATOM 3507 O O . GLU A 1 546 ? -39.471 -16.958 52.591 1.00 80.20 ? 519 GLU B O 1 ATOM 3508 C CB . GLU A 1 546 ? -40.280 -17.745 55.157 1.00 76.52 ? 519 GLU B CB 1 ATOM 3509 N N . ARG A 1 547 ? -40.845 -18.424 51.529 1.00 77.94 ? 520 ARG B N 1 ATOM 3510 C CA . ARG A 1 547 ? -40.183 -18.292 50.199 1.00 71.31 ? 520 ARG B CA 1 ATOM 3511 C C . ARG A 1 547 ? -40.969 -17.491 49.175 1.00 63.63 ? 520 ARG B C 1 ATOM 3512 O O . ARG A 1 547 ? -40.402 -16.815 48.312 1.00 57.56 ? 520 ARG B O 1 ATOM 3513 C CB . ARG A 1 547 ? -40.002 -19.652 49.566 1.00 71.90 ? 520 ARG B CB 1 ATOM 3514 C CG . ARG A 1 547 ? -39.079 -20.602 50.265 1.00 72.34 ? 520 ARG B CG 1 ATOM 3515 C CD . ARG A 1 547 ? -39.572 -21.997 49.933 1.00 81.36 ? 520 ARG B CD 1 ATOM 3516 N NE . ARG A 1 547 ? -38.840 -23.063 50.611 1.00 93.08 ? 520 ARG B NE 1 ATOM 3517 C CZ . ARG A 1 547 ? -39.175 -24.347 50.528 1.00 92.10 ? 520 ARG B CZ 1 ATOM 3518 N NH1 . ARG A 1 547 ? -40.224 -24.723 49.785 1.00 82.07 ? 520 ARG B NH1 1 ATOM 3519 N NH2 . ARG A 1 547 ? -38.468 -25.250 51.196 1.00 93.43 ? 520 ARG B NH2 1 ATOM 3520 N N . LEU A 1 548 ? -42.281 -17.618 49.253 1.00 61.11 ? 521 LEU B N 1 ATOM 3521 C CA . LEU A 1 548 ? -43.205 -16.984 48.319 1.00 62.58 ? 521 LEU B CA 1 ATOM 3522 C C . LEU A 1 548 ? -43.769 -15.682 48.865 1.00 60.85 ? 521 LEU B C 1 ATOM 3523 O O . LEU A 1 548 ? -44.299 -15.644 49.969 1.00 59.82 ? 521 LEU B O 1 ATOM 3524 C CB . LEU A 1 548 ? -44.352 -17.944 48.084 1.00 61.38 ? 521 LEU B CB 1 ATOM 3525 C CG . LEU A 1 548 ? -45.407 -17.652 47.051 1.00 62.74 ? 521 LEU B CG 1 ATOM 3526 C CD1 . LEU A 1 548 ? -44.809 -17.301 45.686 1.00 58.27 ? 521 LEU B CD1 1 ATOM 3527 C CD2 . LEU A 1 548 ? -46.258 -18.919 47.010 1.00 66.45 ? 521 LEU B CD2 1 ATOM 3528 N N . PHE A 1 549 ? -43.665 -14.623 48.077 1.00 63.67 ? 522 PHE B N 1 ATOM 3529 C CA . PHE A 1 549 ? -44.171 -13.321 48.459 1.00 67.63 ? 522 PHE B CA 1 ATOM 3530 C C . PHE A 1 549 ? -45.007 -12.808 47.310 1.00 69.15 ? 522 PHE B C 1 ATOM 3531 O O . PHE A 1 549 ? -44.483 -12.588 46.219 1.00 69.17 ? 522 PHE B O 1 ATOM 3532 C CB . PHE A 1 549 ? -43.010 -12.371 48.766 1.00 73.72 ? 522 PHE B CB 1 ATOM 3533 C CG . PHE A 1 549 ? -42.131 -12.844 49.903 1.00 85.54 ? 522 PHE B CG 1 ATOM 3534 C CD1 . PHE A 1 549 ? -41.121 -13.776 49.685 1.00 86.78 ? 522 PHE B CD1 1 ATOM 3535 C CD2 . PHE A 1 549 ? -42.336 -12.383 51.203 1.00 91.27 ? 522 PHE B CD2 1 ATOM 3536 C CE1 . PHE A 1 549 ? -40.327 -14.224 50.734 1.00 93.14 ? 522 PHE B CE1 1 ATOM 3537 C CE2 . PHE A 1 549 ? -41.548 -12.833 52.255 1.00 94.01 ? 522 PHE B CE2 1 ATOM 3538 C CZ . PHE A 1 549 ? -40.539 -13.753 52.019 1.00 95.47 ? 522 PHE B CZ 1 ATOM 3539 N N . ILE A 1 550 ? -46.307 -12.648 47.548 1.00 68.79 ? 523 ILE B N 1 ATOM 3540 C CA . ILE A 1 550 ? -47.248 -12.238 46.504 1.00 71.69 ? 523 ILE B CA 1 ATOM 3541 C C . ILE A 1 550 ? -48.139 -11.091 46.969 1.00 64.24 ? 523 ILE B C 1 ATOM 3542 O O . ILE A 1 550 ? -48.588 -11.074 48.111 1.00 73.54 ? 523 ILE B O 1 ATOM 3543 C CB . ILE A 1 550 ? -48.123 -13.437 46.055 1.00 74.59 ? 523 ILE B CB 1 ATOM 3544 C CG1 . ILE A 1 550 ? -47.267 -14.457 45.318 1.00 79.27 ? 523 ILE B CG1 1 ATOM 3545 C CG2 . ILE A 1 550 ? -49.253 -12.997 45.136 1.00 82.73 ? 523 ILE B CG2 1 ATOM 3546 C CD1 . ILE A 1 550 ? -48.047 -15.638 44.782 1.00 83.22 ? 523 ILE B CD1 1 ATOM 3547 N N . ASN A 1 551 ? -48.404 -10.152 46.066 1.00 60.70 ? 524 ASN B N 1 ATOM 3548 C CA . ASN A 1 551 ? -49.424 -9.120 46.269 1.00 61.42 ? 524 ASN B CA 1 ATOM 3549 C C . ASN A 1 551 ? -50.763 -9.418 45.598 1.00 57.71 ? 524 ASN B C 1 ATOM 3550 O O . ASN A 1 551 ? -51.036 -8.921 44.512 1.00 56.99 ? 524 ASN B O 1 ATOM 3551 C CB . ASN A 1 551 ? -48.921 -7.796 45.730 1.00 68.67 ? 524 ASN B CB 1 ATOM 3552 C CG . ASN A 1 551 ? -47.673 -7.321 46.430 1.00 78.31 ? 524 ASN B CG 1 ATOM 3553 O OD1 . ASN A 1 551 ? -47.214 -7.921 47.411 1.00 76.74 ? 524 ASN B OD1 1 ATOM 3554 N ND2 . ASN A 1 551 ? -47.111 -6.227 45.925 1.00 83.17 ? 524 ASN B ND2 1 ATOM 3555 N N . GLU A 1 552 ? -51.616 -10.177 46.276 1.00 62.24 ? 525 GLU B N 1 ATOM 3556 C CA . GLU A 1 552 ? -52.968 -10.527 45.784 1.00 67.60 ? 525 GLU B CA 1 ATOM 3557 C C . GLU A 1 552 ? -53.745 -9.339 45.199 1.00 67.62 ? 525 GLU B C 1 ATOM 3558 O O . GLU A 1 552 ? -54.450 -9.494 44.197 1.00 64.16 ? 525 GLU B O 1 ATOM 3559 C CB . GLU A 1 552 ? -53.834 -11.112 46.910 1.00 70.42 ? 525 GLU B CB 1 ATOM 3560 C CG . GLU A 1 552 ? -53.413 -12.447 47.482 1.00 72.53 ? 525 GLU B CG 1 ATOM 3561 C CD . GLU A 1 552 ? -52.517 -12.319 48.685 1.00 73.43 ? 525 GLU B CD 1 ATOM 3562 O OE1 . GLU A 1 552 ? -51.799 -11.317 48.786 1.00 75.64 ? 525 GLU B OE1 1 ATOM 3563 O OE2 . GLU A 1 552 ? -52.504 -13.245 49.513 1.00 89.83 ? 525 GLU B OE2 1 ATOM 3564 N N . GLU A 1 553 ? -53.646 -8.173 45.849 1.00 65.23 ? 526 GLU B N 1 ATOM 3565 C CA . GLU A 1 553 ? -54.287 -6.948 45.351 1.00 65.40 ? 526 GLU B CA 1 ATOM 3566 C C . GLU A 1 553 ? -53.942 -6.662 43.893 1.00 62.44 ? 526 GLU B C 1 ATOM 3567 O O . GLU A 1 553 ? -54.760 -6.112 43.156 1.00 62.41 ? 526 GLU B O 1 ATOM 3568 C CB . GLU A 1 553 ? -53.950 -5.709 46.209 1.00 65.53 ? 526 GLU B CB 1 ATOM 3569 C CG . GLU A 1 553 ? -52.472 -5.357 46.341 1.00 73.70 ? 526 GLU B CG 1 ATOM 3570 C CD . GLU A 1 553 ? -51.802 -5.982 47.569 1.00 83.12 ? 526 GLU B CD 1 ATOM 3571 O OE1 . GLU A 1 553 ? -52.419 -6.819 48.257 1.00 84.55 ? 526 GLU B OE1 1 ATOM 3572 O OE2 . GLU A 1 553 ? -50.639 -5.636 47.861 1.00 92.91 ? 526 GLU B OE2 1 ATOM 3573 N N . LYS A 1 554 ? -52.743 -7.044 43.472 1.00 55.33 ? 527 LYS B N 1 ATOM 3574 C CA . LYS A 1 554 ? -52.284 -6.661 42.162 1.00 54.96 ? 527 LYS B CA 1 ATOM 3575 C C . LYS A 1 554 ? -52.741 -7.577 41.038 1.00 50.82 ? 527 LYS B C 1 ATOM 3576 O O . LYS A 1 554 ? -52.537 -7.247 39.891 1.00 50.92 ? 527 LYS B O 1 ATOM 3577 C CB . LYS A 1 554 ? -50.762 -6.522 42.172 1.00 59.04 ? 527 LYS B CB 1 ATOM 3578 C CG . LYS A 1 554 ? -50.286 -5.149 42.600 1.00 61.12 ? 527 LYS B CG 1 ATOM 3579 C CD . LYS A 1 554 ? -48.918 -5.201 43.247 1.00 67.05 ? 527 LYS B CD 1 ATOM 3580 C CE . LYS A 1 554 ? -48.131 -3.916 43.015 1.00 73.47 ? 527 LYS B CE 1 ATOM 3581 N NZ . LYS A 1 554 ? -47.166 -3.666 44.134 1.00 78.51 ? 527 LYS B NZ 1 ATOM 3582 N N . ILE A 1 555 ? -53.372 -8.712 41.344 1.00 53.72 ? 528 ILE B N 1 ATOM 3583 C CA . ILE A 1 555 ? -53.620 -9.753 40.326 1.00 49.42 ? 528 ILE B CA 1 ATOM 3584 C C . ILE A 1 555 ? -54.963 -9.581 39.645 1.00 49.05 ? 528 ILE B C 1 ATOM 3585 O O . ILE A 1 555 ? -55.961 -9.480 40.311 1.00 56.95 ? 528 ILE B O 1 ATOM 3586 C CB . ILE A 1 555 ? -53.550 -11.180 40.936 1.00 48.74 ? 528 ILE B CB 1 ATOM 3587 C CG1 . ILE A 1 555 ? -52.153 -11.528 41.406 1.00 46.48 ? 528 ILE B CG1 1 ATOM 3588 C CG2 . ILE A 1 555 ? -53.925 -12.270 39.931 1.00 53.72 ? 528 ILE B CG2 1 ATOM 3589 C CD1 . ILE A 1 555 ? -52.141 -12.726 42.324 1.00 48.97 ? 528 ILE B CD1 1 ATOM 3590 N N . LEU A 1 556 ? -54.973 -9.526 38.319 1.00 53.05 ? 529 LEU B N 1 ATOM 3591 C CA . LEU A 1 556 ? -56.161 -9.773 37.504 1.00 55.53 ? 529 LEU B CA 1 ATOM 3592 C C . LEU A 1 556 ? -56.254 -11.231 37.188 1.00 61.29 ? 529 LEU B C 1 ATOM 3593 O O . LEU A 1 556 ? -55.322 -11.781 36.607 1.00 64.60 ? 529 LEU B O 1 ATOM 3594 C CB . LEU A 1 556 ? -56.081 -9.032 36.163 1.00 60.49 ? 529 LEU B CB 1 ATOM 3595 N N . TRP A 1 557 ? -57.378 -11.854 37.541 1.00 64.52 ? 530 TRP B N 1 ATOM 3596 C CA . TRP A 1 557 ? -57.600 -13.282 37.280 1.00 64.49 ? 530 TRP B CA 1 ATOM 3597 C C . TRP A 1 557 ? -58.173 -13.622 35.901 1.00 73.66 ? 530 TRP B C 1 ATOM 3598 O O . TRP A 1 557 ? -58.092 -14.772 35.453 1.00 72.68 ? 530 TRP B O 1 ATOM 3599 C CB . TRP A 1 557 ? -58.496 -13.852 38.359 1.00 63.64 ? 530 TRP B CB 1 ATOM 3600 C CG . TRP A 1 557 ? -57.846 -13.857 39.709 1.00 65.19 ? 530 TRP B CG 1 ATOM 3601 C CD1 . TRP A 1 557 ? -58.134 -13.044 40.765 1.00 64.90 ? 530 TRP B CD1 1 ATOM 3602 C CD2 . TRP A 1 557 ? -56.790 -14.719 40.147 1.00 64.87 ? 530 TRP B CD2 1 ATOM 3603 N NE1 . TRP A 1 557 ? -57.330 -13.349 41.834 1.00 62.76 ? 530 TRP B NE1 1 ATOM 3604 C CE2 . TRP A 1 557 ? -56.496 -14.373 41.484 1.00 63.16 ? 530 TRP B CE2 1 ATOM 3605 C CE3 . TRP A 1 557 ? -56.061 -15.746 39.541 1.00 55.91 ? 530 TRP B CE3 1 ATOM 3606 C CZ2 . TRP A 1 557 ? -55.506 -15.023 42.221 1.00 65.23 ? 530 TRP B CZ2 1 ATOM 3607 C CZ3 . TRP A 1 557 ? -55.076 -16.382 40.276 1.00 56.76 ? 530 TRP B CZ3 1 ATOM 3608 C CH2 . TRP A 1 557 ? -54.815 -16.033 41.599 1.00 59.50 ? 530 TRP B CH2 1 ATOM 3609 N N . SER A 1 558 ? -58.788 -12.628 35.263 1.00 90.08 ? 531 SER B N 1 ATOM 3610 C CA . SER A 1 558 ? -59.132 -12.655 33.823 1.00 95.34 ? 531 SER B CA 1 ATOM 3611 C C . SER A 1 558 ? -58.255 -11.700 32.990 1.00 96.82 ? 531 SER B C 1 ATOM 3612 O O . SER A 1 558 ? -58.359 -11.712 31.759 1.00 90.22 ? 531 SER B O 1 ATOM 3613 C CB . SER A 1 558 ? -60.604 -12.256 33.606 1.00 95.52 ? 531 SER B CB 1 ATOM 3614 O OG . SER A 1 558 ? -60.784 -10.831 33.585 1.00 85.49 ? 531 SER B OG 1 ATOM 3615 N N . GLY A 1 559 ? -57.455 -10.853 33.662 1.00 99.51 ? 532 GLY B N 1 ATOM 3616 C CA . GLY A 1 559 ? -56.527 -9.918 33.008 1.00 97.00 ? 532 GLY B CA 1 ATOM 3617 C C . GLY A 1 559 ? -57.009 -8.495 32.727 1.00 105.18 ? 532 GLY B C 1 ATOM 3618 O O . GLY A 1 559 ? -56.211 -7.655 32.305 1.00 104.00 ? 532 GLY B O 1 ATOM 3619 N N . PHE A 1 560 ? -58.296 -8.211 32.957 1.00 115.01 ? 533 PHE B N 1 ATOM 3620 C CA . PHE A 1 560 ? -58.911 -6.921 32.569 1.00 103.24 ? 533 PHE B CA 1 ATOM 3621 C C . PHE A 1 560 ? -59.414 -6.094 33.784 1.00 102.34 ? 533 PHE B C 1 ATOM 3622 O O . PHE A 1 560 ? -60.170 -6.598 34.623 1.00 102.25 ? 533 PHE B O 1 ATOM 3623 C CB . PHE A 1 560 ? -60.046 -7.176 31.557 1.00 90.28 ? 533 PHE B CB 1 ATOM 3624 N N . SER A 1 561 ? -58.982 -4.826 33.850 1.00 111.69 ? 534 SER B N 1 ATOM 3625 C CA . SER A 1 561 ? -59.332 -3.848 34.920 1.00 112.07 ? 534 SER B CA 1 ATOM 3626 C C . SER A 1 561 ? -60.741 -3.990 35.488 1.00 103.57 ? 534 SER B C 1 ATOM 3627 O O . SER A 1 561 ? -61.704 -3.580 34.853 1.00 102.17 ? 534 SER B O 1 ATOM 3628 C CB . SER A 1 561 ? -59.152 -2.404 34.405 1.00 101.89 ? 534 SER B CB 1 ATOM 3629 N N . PRO B 1 49 ? -9.741 -43.748 16.948 1.00 118.23 ? 22 PRO A N 1 ATOM 3630 C CA . PRO B 1 49 ? -9.539 -44.448 18.214 1.00 119.62 ? 22 PRO A CA 1 ATOM 3631 C C . PRO B 1 49 ? -8.653 -45.693 18.055 1.00 128.12 ? 22 PRO A C 1 ATOM 3632 O O . PRO B 1 49 ? -8.659 -46.340 16.996 1.00 112.69 ? 22 PRO A O 1 ATOM 3633 C CB . PRO B 1 49 ? -10.965 -44.827 18.636 1.00 108.02 ? 22 PRO A CB 1 ATOM 3634 N N . ASP B 1 50 ? -7.902 -46.018 19.107 1.00 136.18 ? 23 ASP A N 1 ATOM 3635 C CA . ASP B 1 50 ? -6.934 -47.128 19.080 1.00 132.53 ? 23 ASP A CA 1 ATOM 3636 C C . ASP B 1 50 ? -7.584 -48.513 18.875 1.00 127.82 ? 23 ASP A C 1 ATOM 3637 O O . ASP B 1 50 ? -7.294 -49.215 17.898 1.00 127.79 ? 23 ASP A O 1 ATOM 3638 C CB . ASP B 1 50 ? -6.091 -47.129 20.372 1.00 132.51 ? 23 ASP A CB 1 ATOM 3639 C CG . ASP B 1 50 ? -5.031 -46.022 20.394 1.00 139.25 ? 23 ASP A CG 1 ATOM 3640 O OD1 . ASP B 1 50 ? -5.083 -45.107 19.539 1.00 135.51 ? 23 ASP A OD1 1 ATOM 3641 O OD2 . ASP B 1 50 ? -4.138 -46.075 21.271 1.00 135.29 ? 23 ASP A OD2 1 ATOM 3642 N N . GLN B 1 51 ? -8.479 -48.879 19.792 1.00 119.71 ? 24 GLN A N 1 ATOM 3643 C CA . GLN B 1 51 ? -9.028 -50.237 19.874 1.00 102.29 ? 24 GLN A CA 1 ATOM 3644 C C . GLN B 1 51 ? -10.245 -50.338 18.934 1.00 88.98 ? 24 GLN A C 1 ATOM 3645 O O . GLN B 1 51 ? -11.222 -49.620 19.112 1.00 87.60 ? 24 GLN A O 1 ATOM 3646 C CB . GLN B 1 51 ? -9.431 -50.509 21.329 1.00 99.15 ? 24 GLN A CB 1 ATOM 3647 C CG . GLN B 1 51 ? -8.963 -51.825 21.927 1.00 106.51 ? 24 GLN A CG 1 ATOM 3648 C CD . GLN B 1 51 ? -9.815 -52.251 23.124 1.00 112.32 ? 24 GLN A CD 1 ATOM 3649 O OE1 . GLN B 1 51 ? -10.569 -51.452 23.680 1.00 125.89 ? 24 GLN A OE1 1 ATOM 3650 N NE2 . GLN B 1 51 ? -9.719 -53.519 23.506 1.00 110.83 ? 24 GLN A NE2 1 ATOM 3651 N N . ARG B 1 52 ? -10.188 -51.204 17.927 1.00 76.11 ? 25 ARG A N 1 ATOM 3652 C CA . ARG B 1 52 ? -11.258 -51.271 16.938 1.00 73.52 ? 25 ARG A CA 1 ATOM 3653 C C . ARG B 1 52 ? -11.251 -52.583 16.176 1.00 68.83 ? 25 ARG A C 1 ATOM 3654 O O . ARG B 1 52 ? -10.444 -53.452 16.450 1.00 66.43 ? 25 ARG A O 1 ATOM 3655 C CB . ARG B 1 52 ? -11.152 -50.099 15.954 1.00 79.47 ? 25 ARG A CB 1 ATOM 3656 C CG . ARG B 1 52 ? -10.197 -50.326 14.793 1.00 83.93 ? 25 ARG A CG 1 ATOM 3657 C CD . ARG B 1 52 ? -10.156 -49.134 13.846 1.00 89.94 ? 25 ARG A CD 1 ATOM 3658 N NE . ARG B 1 52 ? -9.686 -47.902 14.489 1.00 93.94 ? 25 ARG A NE 1 ATOM 3659 C CZ . ARG B 1 52 ? -9.507 -46.743 13.856 1.00 92.80 ? 25 ARG A CZ 1 ATOM 3660 N NH1 . ARG B 1 52 ? -9.750 -46.646 12.551 1.00 88.97 ? 25 ARG A NH1 1 ATOM 3661 N NH2 . ARG B 1 52 ? -9.083 -45.674 14.531 1.00 95.06 ? 25 ARG A NH2 1 ATOM 3662 N N . ALA B 1 53 ? -12.174 -52.716 15.232 1.00 63.45 ? 26 ALA A N 1 ATOM 3663 C CA . ALA B 1 53 ? -12.220 -53.850 14.341 1.00 66.82 ? 26 ALA A CA 1 ATOM 3664 C C . ALA B 1 53 ? -12.492 -53.255 13.002 1.00 72.66 ? 26 ALA A C 1 ATOM 3665 O O . ALA B 1 53 ? -13.409 -52.463 12.882 1.00 72.17 ? 26 ALA A O 1 ATOM 3666 C CB . ALA B 1 53 ? -13.337 -54.801 14.719 1.00 66.82 ? 26 ALA A CB 1 ATOM 3667 N N . GLN B 1 54 ? -11.693 -53.603 11.994 1.00 84.86 ? 27 GLN A N 1 ATOM 3668 C CA . GLN B 1 54 ? -11.913 -53.046 10.662 1.00 88.20 ? 27 GLN A CA 1 ATOM 3669 C C . GLN B 1 54 ? -11.315 -53.870 9.529 1.00 82.35 ? 27 GLN A C 1 ATOM 3670 O O . GLN B 1 54 ? -10.383 -54.631 9.752 1.00 91.15 ? 27 GLN A O 1 ATOM 3671 C CB . GLN B 1 54 ? -11.436 -51.589 10.610 1.00 87.70 ? 27 GLN A CB 1 ATOM 3672 C CG . GLN B 1 54 ? -9.984 -51.358 10.255 1.00 88.27 ? 27 GLN A CG 1 ATOM 3673 C CD . GLN B 1 54 ? -9.744 -49.894 9.955 1.00 87.64 ? 27 GLN A CD 1 ATOM 3674 O OE1 . GLN B 1 54 ? -9.676 -49.065 10.867 1.00 77.61 ? 27 GLN A OE1 1 ATOM 3675 N NE2 . GLN B 1 54 ? -9.659 -49.558 8.669 1.00 82.34 ? 27 GLN A NE2 1 ATOM 3676 N N . LYS B 1 55 ? -11.884 -53.707 8.331 1.00 72.73 ? 28 LYS A N 1 ATOM 3677 C CA . LYS B 1 55 ? -11.392 -54.324 7.098 1.00 68.52 ? 28 LYS A CA 1 ATOM 3678 C C . LYS B 1 55 ? -11.774 -53.425 5.929 1.00 72.22 ? 28 LYS A C 1 ATOM 3679 O O . LYS B 1 55 ? -12.898 -52.939 5.877 1.00 76.06 ? 28 LYS A O 1 ATOM 3680 C CB . LYS B 1 55 ? -12.002 -55.715 6.897 1.00 67.02 ? 28 LYS A CB 1 ATOM 3681 N N . LYS B 1 56 ? -10.845 -53.189 5.002 1.00 76.15 ? 29 LYS A N 1 ATOM 3682 C CA . LYS B 1 56 ? -11.141 -52.432 3.771 1.00 73.65 ? 29 LYS A CA 1 ATOM 3683 C C . LYS B 1 56 ? -12.354 -53.049 3.065 1.00 74.29 ? 29 LYS A C 1 ATOM 3684 O O . LYS B 1 56 ? -12.716 -54.201 3.349 1.00 73.15 ? 29 LYS A O 1 ATOM 3685 C CB . LYS B 1 56 ? -9.928 -52.429 2.824 1.00 67.64 ? 29 LYS A CB 1 ATOM 3686 N N . GLY B 1 57 ? -12.984 -52.288 2.163 1.00 68.26 ? 30 GLY A N 1 ATOM 3687 C CA . GLY B 1 57 ? -14.137 -52.786 1.368 1.00 66.50 ? 30 GLY A CA 1 ATOM 3688 C C . GLY B 1 57 ? -14.669 -51.696 0.450 1.00 70.65 ? 30 GLY A C 1 ATOM 3689 O O . GLY B 1 57 ? -14.242 -50.544 0.543 1.00 75.94 ? 30 GLY A O 1 ATOM 3690 N N . ASP B 1 58 ? -15.595 -52.026 -0.437 1.00 71.13 ? 31 ASP A N 1 ATOM 3691 C CA . ASP B 1 58 ? -16.035 -51.035 -1.424 1.00 79.43 ? 31 ASP A CA 1 ATOM 3692 C C . ASP B 1 58 ? -16.945 -50.031 -0.783 1.00 84.79 ? 31 ASP A C 1 ATOM 3693 O O . ASP B 1 58 ? -16.885 -48.843 -1.084 1.00 89.76 ? 31 ASP A O 1 ATOM 3694 C CB . ASP B 1 58 ? -16.757 -51.708 -2.572 1.00 88.72 ? 31 ASP A CB 1 ATOM 3695 C CG . ASP B 1 58 ? -15.864 -52.674 -3.305 1.00 101.38 ? 31 ASP A CG 1 ATOM 3696 O OD1 . ASP B 1 58 ? -14.881 -52.201 -3.927 1.00 109.32 ? 31 ASP A OD1 1 ATOM 3697 O OD2 . ASP B 1 58 ? -16.135 -53.899 -3.237 1.00 105.39 ? 31 ASP A OD2 1 ATOM 3698 N N . ILE B 1 59 ? -17.799 -50.539 0.097 1.00 90.75 ? 32 ILE A N 1 ATOM 3699 C CA . ILE B 1 59 ? -18.697 -49.741 0.898 1.00 83.42 ? 32 ILE A CA 1 ATOM 3700 C C . ILE B 1 59 ? -18.492 -50.117 2.347 1.00 80.64 ? 32 ILE A C 1 ATOM 3701 O O . ILE B 1 59 ? -18.588 -51.311 2.683 1.00 70.51 ? 32 ILE A O 1 ATOM 3702 C CB . ILE B 1 59 ? -20.142 -50.058 0.529 1.00 82.02 ? 32 ILE A CB 1 ATOM 3703 C CG1 . ILE B 1 59 ? -20.462 -49.444 -0.824 1.00 81.43 ? 32 ILE A CG1 1 ATOM 3704 C CG2 . ILE B 1 59 ? -21.095 -49.534 1.594 1.00 82.58 ? 32 ILE A CG2 1 ATOM 3705 C CD1 . ILE B 1 59 ? -21.649 -50.105 -1.485 1.00 90.80 ? 32 ILE A CD1 1 ATOM 3706 N N . ILE B 1 60 ? -18.256 -49.110 3.196 1.00 76.25 ? 33 ILE A N 1 ATOM 3707 C CA . ILE B 1 60 ? -18.044 -49.345 4.630 1.00 77.87 ? 33 ILE A CA 1 ATOM 3708 C C . ILE B 1 60 ? -19.312 -49.166 5.450 1.00 72.45 ? 33 ILE A C 1 ATOM 3709 O O . ILE B 1 60 ? -20.040 -48.199 5.255 1.00 75.64 ? 33 ILE A O 1 ATOM 3710 C CB . ILE B 1 60 ? -17.001 -48.377 5.219 1.00 83.10 ? 33 ILE A CB 1 ATOM 3711 C CG1 . ILE B 1 60 ? -15.755 -48.331 4.339 1.00 84.63 ? 33 ILE A CG1 1 ATOM 3712 C CG2 . ILE B 1 60 ? -16.634 -48.792 6.645 1.00 83.63 ? 33 ILE A CG2 1 ATOM 3713 C CD1 . ILE B 1 60 ? -15.210 -49.706 4.009 1.00 91.16 ? 33 ILE A CD1 1 ATOM 3714 N N . LEU B 1 61 ? -19.560 -50.102 6.366 1.00 70.45 ? 34 LEU A N 1 ATOM 3715 C CA . LEU B 1 61 ? -20.566 -49.940 7.435 1.00 64.78 ? 34 LEU A CA 1 ATOM 3716 C C . LEU B 1 61 ? -19.920 -49.568 8.745 1.00 61.40 ? 34 LEU A C 1 ATOM 3717 O O . LEU B 1 61 ? -18.985 -50.235 9.174 1.00 55.84 ? 34 LEU A O 1 ATOM 3718 C CB . LEU B 1 61 ? -21.314 -51.239 7.707 1.00 61.49 ? 34 LEU A CB 1 ATOM 3719 C CG . LEU B 1 61 ? -22.065 -51.869 6.556 1.00 66.06 ? 34 LEU A CG 1 ATOM 3720 C CD1 . LEU B 1 61 ? -23.111 -52.800 7.139 1.00 62.47 ? 34 LEU A CD1 1 ATOM 3721 C CD2 . LEU B 1 61 ? -22.684 -50.824 5.628 1.00 69.39 ? 34 LEU A CD2 1 ATOM 3722 N N . GLY B 1 62 ? -20.455 -48.546 9.415 1.00 63.72 ? 35 GLY A N 1 ATOM 3723 C CA . GLY B 1 62 ? -20.037 -48.241 10.796 1.00 59.24 ? 35 GLY A CA 1 ATOM 3724 C C . GLY B 1 62 ? -20.620 -49.223 11.803 1.00 53.65 ? 35 GLY A C 1 ATOM 3725 O O . GLY B 1 62 ? -21.601 -49.901 11.536 1.00 56.89 ? 35 GLY A O 1 ATOM 3726 N N . GLY B 1 63 ? -20.031 -49.289 12.983 1.00 52.27 ? 36 GLY A N 1 ATOM 3727 C CA . GLY B 1 63 ? -20.593 -50.095 14.046 1.00 50.73 ? 36 GLY A CA 1 ATOM 3728 C C . GLY B 1 63 ? -20.263 -49.548 15.412 1.00 52.85 ? 36 GLY A C 1 ATOM 3729 O O . GLY B 1 63 ? -19.122 -49.140 15.644 1.00 49.98 ? 36 GLY A O 1 ATOM 3730 N N . LEU B 1 64 ? -21.249 -49.550 16.322 1.00 49.30 ? 37 LEU A N 1 ATOM 3731 C CA . LEU B 1 64 ? -20.992 -49.174 17.711 1.00 47.66 ? 37 LEU A CA 1 ATOM 3732 C C . LEU B 1 64 ? -21.470 -50.277 18.638 1.00 46.06 ? 37 LEU A C 1 ATOM 3733 O O . LEU B 1 64 ? -22.527 -50.840 18.428 1.00 43.25 ? 37 LEU A O 1 ATOM 3734 C CB . LEU B 1 64 ? -21.698 -47.874 18.023 1.00 48.18 ? 37 LEU A CB 1 ATOM 3735 C CG . LEU B 1 64 ? -21.266 -46.697 17.156 1.00 50.83 ? 37 LEU A CG 1 ATOM 3736 C CD1 . LEU B 1 64 ? -22.188 -45.512 17.406 1.00 52.48 ? 37 LEU A CD1 1 ATOM 3737 C CD2 . LEU B 1 64 ? -19.823 -46.313 17.437 1.00 51.08 ? 37 LEU A CD2 1 ATOM 3738 N N . PHE B 1 65 ? -20.667 -50.617 19.640 1.00 47.43 ? 38 PHE A N 1 ATOM 3739 C CA . PHE B 1 65 ? -20.981 -51.728 20.553 1.00 49.27 ? 38 PHE A CA 1 ATOM 3740 C C . PHE B 1 65 ? -20.326 -51.471 21.877 1.00 50.68 ? 38 PHE A C 1 ATOM 3741 O O . PHE B 1 65 ? -19.255 -50.862 21.917 1.00 45.50 ? 38 PHE A O 1 ATOM 3742 C CB . PHE B 1 65 ? -20.489 -53.070 20.007 1.00 50.50 ? 38 PHE A CB 1 ATOM 3743 C CG . PHE B 1 65 ? -21.193 -53.489 18.769 1.00 49.04 ? 38 PHE A CG 1 ATOM 3744 C CD1 . PHE B 1 65 ? -20.718 -53.101 17.534 1.00 55.88 ? 38 PHE A CD1 1 ATOM 3745 C CD2 . PHE B 1 65 ? -22.358 -54.200 18.839 1.00 48.68 ? 38 PHE A CD2 1 ATOM 3746 C CE1 . PHE B 1 65 ? -21.396 -53.436 16.374 1.00 52.74 ? 38 PHE A CE1 1 ATOM 3747 C CE2 . PHE B 1 65 ? -23.034 -54.550 17.691 1.00 49.88 ? 38 PHE A CE2 1 ATOM 3748 C CZ . PHE B 1 65 ? -22.550 -54.165 16.459 1.00 50.76 ? 38 PHE A CZ 1 ATOM 3749 N N . PRO B 1 66 ? -20.963 -51.925 22.961 1.00 54.04 ? 39 PRO A N 1 ATOM 3750 C CA . PRO B 1 66 ? -20.470 -51.777 24.327 1.00 59.23 ? 39 PRO A CA 1 ATOM 3751 C C . PRO B 1 66 ? -19.603 -52.966 24.806 1.00 61.75 ? 39 PRO A C 1 ATOM 3752 O O . PRO B 1 66 ? -20.052 -53.828 25.576 1.00 62.13 ? 39 PRO A O 1 ATOM 3753 C CB . PRO B 1 66 ? -21.764 -51.677 25.134 1.00 60.41 ? 39 PRO A CB 1 ATOM 3754 C CG . PRO B 1 66 ? -22.735 -52.520 24.366 1.00 60.36 ? 39 PRO A CG 1 ATOM 3755 C CD . PRO B 1 66 ? -22.261 -52.612 22.934 1.00 56.86 ? 39 PRO A CD 1 ATOM 3756 N N . ILE B 1 67 ? -18.356 -52.976 24.357 1.00 61.99 ? 40 ILE A N 1 ATOM 3757 C CA . ILE B 1 67 ? -17.402 -54.046 24.675 1.00 61.45 ? 40 ILE A CA 1 ATOM 3758 C C . ILE B 1 67 ? -17.001 -53.994 26.152 1.00 58.29 ? 40 ILE A C 1 ATOM 3759 O O . ILE B 1 67 ? -16.665 -55.017 26.758 1.00 60.09 ? 40 ILE A O 1 ATOM 3760 C CB . ILE B 1 67 ? -16.126 -53.938 23.795 1.00 59.37 ? 40 ILE A CB 1 ATOM 3761 C CG1 . ILE B 1 67 ? -16.486 -53.838 22.317 1.00 55.13 ? 40 ILE A CG1 1 ATOM 3762 C CG2 . ILE B 1 67 ? -15.220 -55.137 24.023 1.00 64.83 ? 40 ILE A CG2 1 ATOM 3763 C CD1 . ILE B 1 67 ? -17.448 -54.911 21.853 1.00 58.16 ? 40 ILE A CD1 1 ATOM 3764 N N . HIS B 1 68 ? -17.013 -52.789 26.701 1.00 57.58 ? 41 HIS A N 1 ATOM 3765 C CA . HIS B 1 68 ? -16.941 -52.580 28.131 1.00 64.98 ? 41 HIS A CA 1 ATOM 3766 C C . HIS B 1 68 ? -18.235 -52.011 28.669 1.00 57.54 ? 41 HIS A C 1 ATOM 3767 O O . HIS B 1 68 ? -18.921 -51.252 27.996 1.00 58.79 ? 41 HIS A O 1 ATOM 3768 C CB . HIS B 1 68 ? -15.818 -51.618 28.459 1.00 70.50 ? 41 HIS A CB 1 ATOM 3769 C CG . HIS B 1 68 ? -14.487 -52.144 28.080 1.00 73.40 ? 41 HIS A CG 1 ATOM 3770 N ND1 . HIS B 1 68 ? -13.965 -51.983 26.818 1.00 73.45 ? 41 HIS A ND1 1 ATOM 3771 C CD2 . HIS B 1 68 ? -13.595 -52.883 28.775 1.00 80.07 ? 41 HIS A CD2 1 ATOM 3772 C CE1 . HIS B 1 68 ? -12.786 -52.573 26.762 1.00 77.46 ? 41 HIS A CE1 1 ATOM 3773 N NE2 . HIS B 1 68 ? -12.542 -53.132 27.935 1.00 80.60 ? 41 HIS A NE2 1 ATOM 3774 N N . PHE B 1 69 ? -18.551 -52.375 29.900 1.00 53.59 ? 42 PHE A N 1 ATOM 3775 C CA . PHE B 1 69 ? -19.784 -51.921 30.522 1.00 54.58 ? 42 PHE A CA 1 ATOM 3776 C C . PHE B 1 69 ? -19.738 -50.450 30.957 1.00 51.89 ? 42 PHE A C 1 ATOM 3777 O O . PHE B 1 69 ? -20.778 -49.845 31.200 1.00 58.50 ? 42 PHE A O 1 ATOM 3778 C CB . PHE B 1 69 ? -20.093 -52.777 31.745 1.00 53.67 ? 42 PHE A CB 1 ATOM 3779 C CG . PHE B 1 69 ? -20.666 -54.126 31.432 1.00 53.25 ? 42 PHE A CG 1 ATOM 3780 C CD1 . PHE B 1 69 ? -21.871 -54.251 30.760 1.00 57.95 ? 42 PHE A CD1 1 ATOM 3781 C CD2 . PHE B 1 69 ? -20.042 -55.279 31.893 1.00 57.32 ? 42 PHE A CD2 1 ATOM 3782 C CE1 . PHE B 1 69 ? -22.429 -55.513 30.523 1.00 62.96 ? 42 PHE A CE1 1 ATOM 3783 C CE2 . PHE B 1 69 ? -20.588 -56.538 31.668 1.00 56.81 ? 42 PHE A CE2 1 ATOM 3784 C CZ . PHE B 1 69 ? -21.781 -56.662 30.978 1.00 59.32 ? 42 PHE A CZ 1 ATOM 3785 N N . GLY B 1 70 ? -18.552 -49.884 31.091 1.00 48.68 ? 43 GLY A N 1 ATOM 3786 C CA . GLY B 1 70 ? -18.440 -48.546 31.621 1.00 53.47 ? 43 GLY A CA 1 ATOM 3787 C C . GLY B 1 70 ? -17.050 -47.970 31.610 1.00 58.29 ? 43 GLY A C 1 ATOM 3788 O O . GLY B 1 70 ? -16.134 -48.526 31.035 1.00 75.27 ? 43 GLY A O 1 ATOM 3789 N N . VAL B 1 71 ? -16.898 -46.847 32.272 1.00 64.26 ? 44 VAL A N 1 ATOM 3790 C CA . VAL B 1 71 ? -15.642 -46.122 32.295 1.00 71.02 ? 44 VAL A CA 1 ATOM 3791 C C . VAL B 1 71 ? -15.176 -46.048 33.745 1.00 68.80 ? 44 VAL A C 1 ATOM 3792 O O . VAL B 1 71 ? -15.978 -46.143 34.674 1.00 60.48 ? 44 VAL A O 1 ATOM 3793 C CB . VAL B 1 71 ? -15.871 -44.717 31.674 1.00 79.97 ? 44 VAL A CB 1 ATOM 3794 C CG1 . VAL B 1 71 ? -14.870 -43.687 32.165 1.00 86.38 ? 44 VAL A CG1 1 ATOM 3795 C CG2 . VAL B 1 71 ? -15.843 -44.806 30.153 1.00 84.36 ? 44 VAL A CG2 1 ATOM 3796 N N . ALA B 1 72 ? -13.874 -45.893 33.947 1.00 80.19 ? 45 ALA A N 1 ATOM 3797 C CA . ALA B 1 72 ? -13.336 -45.651 35.292 1.00 81.26 ? 45 ALA A CA 1 ATOM 3798 C C . ALA B 1 72 ? -13.639 -44.200 35.631 1.00 88.28 ? 45 ALA A C 1 ATOM 3799 O O . ALA B 1 72 ? -13.203 -43.285 34.930 1.00 85.23 ? 45 ALA A O 1 ATOM 3800 C CB . ALA B 1 72 ? -11.843 -45.905 35.322 1.00 82.42 ? 45 ALA A CB 1 ATOM 3801 N N . ALA B 1 73 ? -14.397 -43.982 36.693 1.00 101.51 ? 46 ALA A N 1 ATOM 3802 C CA . ALA B 1 73 ? -14.992 -42.666 36.918 1.00 116.47 ? 46 ALA A CA 1 ATOM 3803 C C . ALA B 1 73 ? -14.066 -41.700 37.673 1.00 119.34 ? 46 ALA A C 1 ATOM 3804 O O . ALA B 1 73 ? -14.521 -40.954 38.530 1.00 115.11 ? 46 ALA A O 1 ATOM 3805 C CB . ALA B 1 73 ? -16.328 -42.813 37.641 1.00 117.64 ? 46 ALA A CB 1 ATOM 3806 N N . LYS B 1 74 ? -12.778 -41.692 37.331 1.00 123.21 ? 47 LYS A N 1 ATOM 3807 C CA . LYS B 1 74 ? -11.818 -40.793 37.962 1.00 112.64 ? 47 LYS A CA 1 ATOM 3808 C C . LYS B 1 74 ? -12.134 -39.341 37.602 1.00 108.44 ? 47 LYS A C 1 ATOM 3809 O O . LYS B 1 74 ? -11.840 -38.915 36.482 1.00 111.88 ? 47 LYS A O 1 ATOM 3810 C CB . LYS B 1 74 ? -10.400 -41.149 37.505 1.00 114.39 ? 47 LYS A CB 1 ATOM 3811 N N . ASP B 1 75 ? -12.739 -38.602 38.546 1.00 109.35 ? 48 ASP A N 1 ATOM 3812 C CA . ASP B 1 75 ? -13.073 -37.161 38.378 1.00 108.07 ? 48 ASP A CA 1 ATOM 3813 C C . ASP B 1 75 ? -11.807 -36.310 38.227 1.00 98.58 ? 48 ASP A C 1 ATOM 3814 O O . ASP B 1 75 ? -10.840 -36.480 38.977 1.00 83.07 ? 48 ASP A O 1 ATOM 3815 C CB . ASP B 1 75 ? -13.909 -36.626 39.556 1.00 102.20 ? 48 ASP A CB 1 ATOM 3816 N N . GLN B 1 76 ? -11.826 -35.409 37.247 1.00 88.73 ? 49 GLN A N 1 ATOM 3817 C CA . GLN B 1 76 ? -10.641 -34.663 36.863 1.00 88.67 ? 49 GLN A CA 1 ATOM 3818 C C . GLN B 1 76 ? -10.673 -33.280 37.474 1.00 79.87 ? 49 GLN A C 1 ATOM 3819 O O . GLN B 1 76 ? -11.598 -32.524 37.241 1.00 70.84 ? 49 GLN A O 1 ATOM 3820 C CB . GLN B 1 76 ? -10.545 -34.539 35.344 1.00 90.79 ? 49 GLN A CB 1 ATOM 3821 C CG . GLN B 1 76 ? -9.688 -35.604 34.693 1.00 93.41 ? 49 GLN A CG 1 ATOM 3822 C CD . GLN B 1 76 ? -10.178 -35.939 33.299 1.00 103.34 ? 49 GLN A CD 1 ATOM 3823 O OE1 . GLN B 1 76 ? -11.357 -35.761 32.987 1.00 117.15 ? 49 GLN A OE1 1 ATOM 3824 N NE2 . GLN B 1 76 ? -9.284 -36.434 32.454 1.00 99.19 ? 49 GLN A NE2 1 ATOM 3825 N N . ASP B 1 77 ? -9.641 -32.958 38.243 1.00 75.12 ? 50 ASP A N 1 ATOM 3826 C CA . ASP B 1 77 ? -9.492 -31.630 38.799 1.00 74.60 ? 50 ASP A CA 1 ATOM 3827 C C . ASP B 1 77 ? -8.879 -30.635 37.770 1.00 70.22 ? 50 ASP A C 1 ATOM 3828 O O . ASP B 1 77 ? -8.710 -29.439 38.094 1.00 54.22 ? 50 ASP A O 1 ATOM 3829 C CB . ASP B 1 77 ? -8.695 -31.672 40.122 1.00 77.48 ? 50 ASP A CB 1 ATOM 3830 C CG . ASP B 1 77 ? -7.359 -32.428 40.007 1.00 79.09 ? 50 ASP A CG 1 ATOM 3831 O OD1 . ASP B 1 77 ? -6.903 -32.706 38.873 1.00 78.63 ? 50 ASP A OD1 1 ATOM 3832 O OD2 . ASP B 1 77 ? -6.769 -32.744 41.071 1.00 81.92 ? 50 ASP A OD2 1 ATOM 3833 N N . LEU B 1 78 ? -8.582 -31.105 36.542 1.00 63.64 ? 51 LEU A N 1 ATOM 3834 C CA . LEU B 1 78 ? -8.081 -30.217 35.468 1.00 66.01 ? 51 LEU A CA 1 ATOM 3835 C C . LEU B 1 78 ? -6.966 -29.300 35.953 1.00 70.42 ? 51 LEU A C 1 ATOM 3836 O O . LEU B 1 78 ? -7.005 -28.071 35.733 1.00 62.50 ? 51 LEU A O 1 ATOM 3837 C CB . LEU B 1 78 ? -9.192 -29.315 34.938 1.00 63.97 ? 51 LEU A CB 1 ATOM 3838 C CG . LEU B 1 78 ? -10.394 -29.939 34.271 1.00 60.36 ? 51 LEU A CG 1 ATOM 3839 C CD1 . LEU B 1 78 ? -11.410 -28.838 33.970 1.00 62.32 ? 51 LEU A CD1 1 ATOM 3840 C CD2 . LEU B 1 78 ? -9.942 -30.629 33.008 1.00 58.20 ? 51 LEU A CD2 1 ATOM 3841 N N . LYS B 1 79 ? -6.018 -29.903 36.669 1.00 80.21 ? 52 LYS A N 1 ATOM 3842 C CA . LYS B 1 79 ? -4.790 -29.244 37.098 1.00 76.90 ? 52 LYS A CA 1 ATOM 3843 C C . LYS B 1 79 ? -3.776 -29.358 35.978 1.00 71.02 ? 52 LYS A C 1 ATOM 3844 O O . LYS B 1 79 ? -2.872 -28.542 35.868 1.00 72.14 ? 52 LYS A O 1 ATOM 3845 C CB . LYS B 1 79 ? -4.233 -29.905 38.356 1.00 86.60 ? 52 LYS A CB 1 ATOM 3846 C CG . LYS B 1 79 ? -4.606 -29.225 39.661 1.00 92.84 ? 52 LYS A CG 1 ATOM 3847 C CD . LYS B 1 79 ? -3.794 -29.832 40.803 1.00 103.62 ? 52 LYS A CD 1 ATOM 3848 C CE . LYS B 1 79 ? -3.562 -28.848 41.930 1.00 108.03 ? 52 LYS A CE 1 ATOM 3849 N NZ . LYS B 1 79 ? -4.847 -28.476 42.583 1.00 116.05 ? 52 LYS A NZ 1 ATOM 3850 N N . SER B 1 80 ? -3.923 -30.395 35.160 1.00 72.36 ? 53 SER A N 1 ATOM 3851 C CA . SER B 1 80 ? -3.115 -30.566 33.962 1.00 72.82 ? 53 SER A CA 1 ATOM 3852 C C . SER B 1 80 ? -4.049 -30.983 32.850 1.00 67.50 ? 53 SER A C 1 ATOM 3853 O O . SER B 1 80 ? -5.221 -31.208 33.101 1.00 66.85 ? 53 SER A O 1 ATOM 3854 C CB . SER B 1 80 ? -2.089 -31.659 34.182 1.00 72.16 ? 53 SER A CB 1 ATOM 3855 O OG . SER B 1 80 ? -2.718 -32.928 34.134 1.00 68.51 ? 53 SER A OG 1 ATOM 3856 N N . ARG B 1 81 ? -3.523 -31.100 31.636 1.00 71.29 ? 54 ARG A N 1 ATOM 3857 C CA . ARG B 1 81 ? -4.327 -31.448 30.479 1.00 71.77 ? 54 ARG A CA 1 ATOM 3858 C C . ARG B 1 81 ? -5.052 -32.737 30.810 1.00 68.14 ? 54 ARG A C 1 ATOM 3859 O O . ARG B 1 81 ? -4.468 -33.613 31.414 1.00 66.86 ? 54 ARG A O 1 ATOM 3860 C CB . ARG B 1 81 ? -3.467 -31.630 29.227 1.00 79.13 ? 54 ARG A CB 1 ATOM 3861 C CG . ARG B 1 81 ? -4.197 -32.316 28.064 1.00 95.69 ? 54 ARG A CG 1 ATOM 3862 C CD . ARG B 1 81 ? -3.851 -31.752 26.687 1.00 103.06 ? 54 ARG A CD 1 ATOM 3863 N NE . ARG B 1 81 ? -2.407 -31.565 26.489 1.00 113.23 ? 54 ARG A NE 1 ATOM 3864 C CZ . ARG B 1 81 ? -1.741 -30.413 26.631 1.00 113.88 ? 54 ARG A CZ 1 ATOM 3865 N NH1 . ARG B 1 81 ? -2.358 -29.286 26.982 1.00 118.54 ? 54 ARG A NH1 1 ATOM 3866 N NH2 . ARG B 1 81 ? -0.436 -30.387 26.416 1.00 110.11 ? 54 ARG A NH2 1 ATOM 3867 N N . PRO B 1 82 ? -6.337 -32.832 30.450 1.00 69.62 ? 55 PRO A N 1 ATOM 3868 C CA . PRO B 1 82 ? -7.041 -34.079 30.726 1.00 72.77 ? 55 PRO A CA 1 ATOM 3869 C C . PRO B 1 82 ? -6.674 -35.172 29.747 1.00 73.61 ? 55 PRO A C 1 ATOM 3870 O O . PRO B 1 82 ? -6.620 -34.918 28.556 1.00 75.46 ? 55 PRO A O 1 ATOM 3871 C CB . PRO B 1 82 ? -8.530 -33.714 30.589 1.00 74.33 ? 55 PRO A CB 1 ATOM 3872 C CG . PRO B 1 82 ? -8.594 -32.262 30.258 1.00 74.46 ? 55 PRO A CG 1 ATOM 3873 C CD . PRO B 1 82 ? -7.226 -31.742 29.989 1.00 71.23 ? 55 PRO A CD 1 ATOM 3874 N N . GLU B 1 83 ? -6.422 -36.375 30.259 1.00 79.59 ? 56 GLU A N 1 ATOM 3875 C CA . GLU B 1 83 ? -6.237 -37.561 29.427 1.00 84.71 ? 56 GLU A CA 1 ATOM 3876 C C . GLU B 1 83 ? -7.613 -38.155 29.193 1.00 74.19 ? 56 GLU A C 1 ATOM 3877 O O . GLU B 1 83 ? -8.542 -37.762 29.850 1.00 74.98 ? 56 GLU A O 1 ATOM 3878 C CB . GLU B 1 83 ? -5.331 -38.582 30.135 1.00 87.92 ? 56 GLU A CB 1 ATOM 3879 N N . SER B 1 84 ? -7.752 -39.095 28.268 1.00 71.61 ? 57 SER A N 1 ATOM 3880 C CA . SER B 1 84 ? -9.030 -39.765 28.071 1.00 80.31 ? 57 SER A CA 1 ATOM 3881 C C . SER B 1 84 ? -9.394 -40.698 29.267 1.00 84.07 ? 57 SER A C 1 ATOM 3882 O O . SER B 1 84 ? -8.516 -41.125 30.027 1.00 79.11 ? 57 SER A O 1 ATOM 3883 C CB . SER B 1 84 ? -9.011 -40.568 26.766 1.00 84.97 ? 57 SER A CB 1 ATOM 3884 O OG . SER B 1 84 ? -8.457 -41.863 26.973 1.00 84.34 ? 57 SER A OG 1 ATOM 3885 N N . VAL B 1 85 ? -10.688 -40.998 29.421 1.00 78.07 ? 58 VAL A N 1 ATOM 3886 C CA . VAL B 1 85 ? -11.162 -41.965 30.417 1.00 79.62 ? 58 VAL A CA 1 ATOM 3887 C C . VAL B 1 85 ? -10.836 -43.392 29.955 1.00 76.73 ? 58 VAL A C 1 ATOM 3888 O O . VAL B 1 85 ? -10.713 -43.637 28.761 1.00 81.74 ? 58 VAL A O 1 ATOM 3889 C CB . VAL B 1 85 ? -12.682 -41.827 30.643 1.00 81.49 ? 58 VAL A CB 1 ATOM 3890 N N . GLU B 1 86 ? -10.670 -44.320 30.893 1.00 73.40 ? 59 GLU A N 1 ATOM 3891 C CA . GLU B 1 86 ? -10.302 -45.690 30.558 1.00 71.23 ? 59 GLU A CA 1 ATOM 3892 C C . GLU B 1 86 ? -11.532 -46.556 30.707 1.00 69.10 ? 59 GLU A C 1 ATOM 3893 O O . GLU B 1 86 ? -12.269 -46.440 31.677 1.00 71.84 ? 59 GLU A O 1 ATOM 3894 C CB . GLU B 1 86 ? -9.190 -46.211 31.473 1.00 70.36 ? 59 GLU A CB 1 ATOM 3895 N N . CYS B 1 87 ? -11.747 -47.423 29.735 1.00 65.94 ? 60 CYS A N 1 ATOM 3896 C CA . CYS B 1 87 ? -12.878 -48.308 29.749 1.00 67.24 ? 60 CYS A CA 1 ATOM 3897 C C . CYS B 1 87 ? -12.617 -49.464 30.693 1.00 69.46 ? 60 CYS A C 1 ATOM 3898 O O . CYS B 1 87 ? -11.535 -50.024 30.714 1.00 73.84 ? 60 CYS A O 1 ATOM 3899 C CB . CYS B 1 87 ? -13.175 -48.776 28.325 1.00 74.70 ? 60 CYS A CB 1 ATOM 3900 S SG . CYS B 1 87 ? -13.877 -47.409 27.331 1.00 83.75 ? 60 CYS A SG 1 ATOM 3901 N N . ILE B 1 88 ? -13.616 -49.813 31.487 1.00 73.05 ? 61 ILE A N 1 ATOM 3902 C CA . ILE B 1 88 ? -13.440 -50.767 32.562 1.00 74.04 ? 61 ILE A CA 1 ATOM 3903 C C . ILE B 1 88 ? -14.588 -51.788 32.510 1.00 72.85 ? 61 ILE A C 1 ATOM 3904 O O . ILE B 1 88 ? -15.697 -51.459 32.071 1.00 78.05 ? 61 ILE A O 1 ATOM 3905 C CB . ILE B 1 88 ? -13.276 -49.999 33.915 1.00 80.41 ? 61 ILE A CB 1 ATOM 3906 C CG1 . ILE B 1 88 ? -12.189 -50.632 34.784 1.00 97.27 ? 61 ILE A CG1 1 ATOM 3907 C CG2 . ILE B 1 88 ? -14.573 -49.872 34.704 1.00 82.53 ? 61 ILE A CG2 1 ATOM 3908 C CD1 . ILE B 1 88 ? -10.775 -50.447 34.252 1.00 103.34 ? 61 ILE A CD1 1 ATOM 3909 N N . ARG B 1 89 ? -14.288 -53.023 32.915 1.00 67.45 ? 62 ARG A N 1 ATOM 3910 C CA . ARG B 1 89 ? -15.212 -54.192 32.897 1.00 65.57 ? 62 ARG A CA 1 ATOM 3911 C C . ARG B 1 89 ? -15.628 -54.655 31.500 1.00 65.85 ? 62 ARG A C 1 ATOM 3912 O O . ARG B 1 89 ? -16.392 -53.993 30.801 1.00 68.39 ? 62 ARG A O 1 ATOM 3913 C CB . ARG B 1 89 ? -16.430 -53.981 33.783 1.00 67.26 ? 62 ARG A CB 1 ATOM 3914 C CG . ARG B 1 89 ? -16.071 -53.504 35.181 1.00 73.13 ? 62 ARG A CG 1 ATOM 3915 C CD . ARG B 1 89 ? -17.290 -52.934 35.884 1.00 84.91 ? 62 ARG A CD 1 ATOM 3916 N NE . ARG B 1 89 ? -18.114 -54.017 36.396 1.00 96.64 ? 62 ARG A NE 1 ATOM 3917 C CZ . ARG B 1 89 ? -19.438 -53.984 36.515 1.00 106.21 ? 62 ARG A CZ 1 ATOM 3918 N NH1 . ARG B 1 89 ? -20.134 -52.913 36.149 1.00 102.05 ? 62 ARG A NH1 1 ATOM 3919 N NH2 . ARG B 1 89 ? -20.071 -55.048 37.001 1.00 113.78 ? 62 ARG A NH2 1 ATOM 3920 N N . TYR B 1 90 ? -15.121 -55.823 31.122 1.00 64.93 ? 63 TYR A N 1 ATOM 3921 C CA . TYR B 1 90 ? -15.265 -56.343 29.782 1.00 65.08 ? 63 TYR A CA 1 ATOM 3922 C C . TYR B 1 90 ? -16.658 -56.930 29.684 1.00 66.95 ? 63 TYR A C 1 ATOM 3923 O O . TYR B 1 90 ? -17.112 -57.587 30.617 1.00 78.67 ? 63 TYR A O 1 ATOM 3924 C CB . TYR B 1 90 ? -14.190 -57.417 29.487 1.00 59.43 ? 63 TYR A CB 1 ATOM 3925 C CG . TYR B 1 90 ? -14.002 -57.654 28.000 1.00 57.83 ? 63 TYR A CG 1 ATOM 3926 C CD1 . TYR B 1 90 ? -13.098 -56.906 27.269 1.00 57.94 ? 63 TYR A CD1 1 ATOM 3927 C CD2 . TYR B 1 90 ? -14.757 -58.595 27.318 1.00 59.34 ? 63 TYR A CD2 1 ATOM 3928 C CE1 . TYR B 1 90 ? -12.936 -57.094 25.896 1.00 56.34 ? 63 TYR A CE1 1 ATOM 3929 C CE2 . TYR B 1 90 ? -14.602 -58.786 25.946 1.00 60.02 ? 63 TYR A CE2 1 ATOM 3930 C CZ . TYR B 1 90 ? -13.694 -58.023 25.247 1.00 56.42 ? 63 TYR A CZ 1 ATOM 3931 O OH . TYR B 1 90 ? -13.547 -58.190 23.890 1.00 63.84 ? 63 TYR A OH 1 ATOM 3932 N N . ASN B 1 91 ? -17.335 -56.682 28.570 1.00 62.30 ? 64 ASN A N 1 ATOM 3933 C CA . ASN B 1 91 ? -18.692 -57.172 28.370 1.00 65.82 ? 64 ASN A CA 1 ATOM 3934 C C . ASN B 1 91 ? -18.716 -58.209 27.254 1.00 64.03 ? 64 ASN A C 1 ATOM 3935 O O . ASN B 1 91 ? -18.774 -57.870 26.068 1.00 57.14 ? 64 ASN A O 1 ATOM 3936 C CB . ASN B 1 91 ? -19.635 -55.994 28.072 1.00 67.77 ? 64 ASN A CB 1 ATOM 3937 C CG . ASN B 1 91 ? -21.017 -56.431 27.604 1.00 67.33 ? 64 ASN A CG 1 ATOM 3938 O OD1 . ASN B 1 91 ? -21.457 -57.577 27.816 1.00 65.57 ? 64 ASN A OD1 1 ATOM 3939 N ND2 . ASN B 1 91 ? -21.707 -55.514 26.940 1.00 68.63 ? 64 ASN A ND2 1 ATOM 3940 N N . PHE B 1 92 ? -18.686 -59.475 27.657 1.00 66.53 ? 65 PHE A N 1 ATOM 3941 C CA . PHE B 1 92 ? -18.623 -60.611 26.719 1.00 68.91 ? 65 PHE A CA 1 ATOM 3942 C C . PHE B 1 92 ? -19.834 -60.764 25.792 1.00 63.60 ? 65 PHE A C 1 ATOM 3943 O O . PHE B 1 92 ? -19.723 -61.164 24.626 1.00 59.10 ? 65 PHE A O 1 ATOM 3944 C CB . PHE B 1 92 ? -18.447 -61.901 27.515 1.00 71.28 ? 65 PHE A CB 1 ATOM 3945 C CG . PHE B 1 92 ? -17.087 -62.040 28.133 1.00 69.02 ? 65 PHE A CG 1 ATOM 3946 C CD1 . PHE B 1 92 ? -15.985 -62.341 27.344 1.00 68.45 ? 65 PHE A CD1 1 ATOM 3947 C CD2 . PHE B 1 92 ? -16.908 -61.867 29.488 1.00 67.65 ? 65 PHE A CD2 1 ATOM 3948 C CE1 . PHE B 1 92 ? -14.725 -62.463 27.898 1.00 65.57 ? 65 PHE A CE1 1 ATOM 3949 C CE2 . PHE B 1 92 ? -15.654 -61.995 30.048 1.00 72.45 ? 65 PHE A CE2 1 ATOM 3950 C CZ . PHE B 1 92 ? -14.557 -62.291 29.249 1.00 68.88 ? 65 PHE A CZ 1 ATOM 3951 N N . ARG B 1 93 ? -21.001 -60.464 26.320 1.00 63.47 ? 66 ARG A N 1 ATOM 3952 C CA . ARG B 1 93 ? -22.201 -60.462 25.509 1.00 62.78 ? 66 ARG A CA 1 ATOM 3953 C C . ARG B 1 93 ? -22.077 -59.397 24.406 1.00 59.69 ? 66 ARG A C 1 ATOM 3954 O O . ARG B 1 93 ? -22.528 -59.584 23.265 1.00 54.46 ? 66 ARG A O 1 ATOM 3955 C CB . ARG B 1 93 ? -23.398 -60.190 26.409 1.00 59.29 ? 66 ARG A CB 1 ATOM 3956 C CG . ARG B 1 93 ? -24.724 -60.402 25.743 1.00 58.85 ? 66 ARG A CG 1 ATOM 3957 C CD . ARG B 1 93 ? -25.807 -60.063 26.719 1.00 60.43 ? 66 ARG A CD 1 ATOM 3958 N NE . ARG B 1 93 ? -27.115 -60.048 26.083 1.00 67.32 ? 66 ARG A NE 1 ATOM 3959 C CZ . ARG B 1 93 ? -28.247 -59.838 26.741 1.00 65.84 ? 66 ARG A CZ 1 ATOM 3960 N NH1 . ARG B 1 93 ? -28.224 -59.628 28.059 1.00 58.86 ? 66 ARG A NH1 1 ATOM 3961 N NH2 . ARG B 1 93 ? -29.396 -59.855 26.076 1.00 66.16 ? 66 ARG A NH2 1 ATOM 3962 N N . GLY B 1 94 ? -21.446 -58.283 24.757 1.00 58.42 ? 67 GLY A N 1 ATOM 3963 C CA . GLY B 1 94 ? -21.247 -57.180 23.820 1.00 59.28 ? 67 GLY A CA 1 ATOM 3964 C C . GLY B 1 94 ? -20.297 -57.509 22.686 1.00 58.56 ? 67 GLY A C 1 ATOM 3965 O O . GLY B 1 94 ? -20.514 -57.074 21.519 1.00 52.32 ? 67 GLY A O 1 ATOM 3966 N N . PHE B 1 95 ? -19.235 -58.256 23.028 1.00 57.83 ? 68 PHE A N 1 ATOM 3967 C CA . PHE B 1 95 ? -18.311 -58.791 22.020 1.00 60.20 ? 68 PHE A CA 1 ATOM 3968 C C . PHE B 1 95 ? -19.055 -59.724 21.055 1.00 56.83 ? 68 PHE A C 1 ATOM 3969 O O . PHE B 1 95 ? -18.902 -59.617 19.850 1.00 57.56 ? 68 PHE A O 1 ATOM 3970 C CB . PHE B 1 95 ? -17.131 -59.502 22.674 1.00 67.14 ? 68 PHE A CB 1 ATOM 3971 C CG . PHE B 1 95 ? -16.048 -59.914 21.700 1.00 76.46 ? 68 PHE A CG 1 ATOM 3972 C CD1 . PHE B 1 95 ? -15.263 -58.969 21.067 1.00 81.92 ? 68 PHE A CD1 1 ATOM 3973 C CD2 . PHE B 1 95 ? -15.804 -61.259 21.434 1.00 83.11 ? 68 PHE A CD2 1 ATOM 3974 C CE1 . PHE B 1 95 ? -14.272 -59.360 20.178 1.00 87.27 ? 68 PHE A CE1 1 ATOM 3975 C CE2 . PHE B 1 95 ? -14.814 -61.657 20.547 1.00 78.88 ? 68 PHE A CE2 1 ATOM 3976 C CZ . PHE B 1 95 ? -14.051 -60.709 19.917 1.00 80.53 ? 68 PHE A CZ 1 ATOM 3977 N N . ARG B 1 96 ? -19.906 -60.596 21.573 1.00 54.70 ? 69 ARG A N 1 ATOM 3978 C CA . ARG B 1 96 ? -20.719 -61.431 20.697 1.00 57.77 ? 69 ARG A CA 1 ATOM 3979 C C . ARG B 1 96 ? -21.583 -60.604 19.756 1.00 54.01 ? 69 ARG A C 1 ATOM 3980 O O . ARG B 1 96 ? -21.688 -60.939 18.571 1.00 48.26 ? 69 ARG A O 1 ATOM 3981 C CB . ARG B 1 96 ? -21.585 -62.414 21.490 1.00 61.58 ? 69 ARG A CB 1 ATOM 3982 C CG . ARG B 1 96 ? -22.726 -62.997 20.679 1.00 63.90 ? 69 ARG A CG 1 ATOM 3983 C CD . ARG B 1 96 ? -23.260 -64.289 21.280 1.00 70.74 ? 69 ARG A CD 1 ATOM 3984 N NE . ARG B 1 96 ? -23.370 -64.281 22.744 1.00 72.23 ? 69 ARG A NE 1 ATOM 3985 C CZ . ARG B 1 96 ? -24.462 -63.970 23.440 1.00 67.30 ? 69 ARG A CZ 1 ATOM 3986 N NH1 . ARG B 1 96 ? -25.583 -63.598 22.844 1.00 75.13 ? 69 ARG A NH1 1 ATOM 3987 N NH2 . ARG B 1 96 ? -24.421 -64.020 24.753 1.00 67.73 ? 69 ARG A NH2 1 ATOM 3988 N N . TRP B 1 97 ? -22.215 -59.541 20.265 1.00 57.26 ? 70 TRP A N 1 ATOM 3989 C CA . TRP B 1 97 ? -23.020 -58.672 19.382 1.00 56.81 ? 70 TRP A CA 1 ATOM 3990 C C . TRP B 1 97 ? -22.179 -58.112 18.235 1.00 56.76 ? 70 TRP A C 1 ATOM 3991 O O . TRP B 1 97 ? -22.592 -58.154 17.079 1.00 56.18 ? 70 TRP A O 1 ATOM 3992 C CB . TRP B 1 97 ? -23.668 -57.511 20.126 1.00 59.24 ? 70 TRP A CB 1 ATOM 3993 C CG . TRP B 1 97 ? -24.644 -57.911 21.177 1.00 58.16 ? 70 TRP A CG 1 ATOM 3994 C CD1 . TRP B 1 97 ? -25.196 -59.121 21.356 1.00 56.06 ? 70 TRP A CD1 1 ATOM 3995 C CD2 . TRP B 1 97 ? -25.186 -57.065 22.184 1.00 56.42 ? 70 TRP A CD2 1 ATOM 3996 N NE1 . TRP B 1 97 ? -26.040 -59.106 22.430 1.00 54.82 ? 70 TRP A NE1 1 ATOM 3997 C CE2 . TRP B 1 97 ? -26.048 -57.850 22.963 1.00 58.87 ? 70 TRP A CE2 1 ATOM 3998 C CE3 . TRP B 1 97 ? -25.023 -55.718 22.504 1.00 52.11 ? 70 TRP A CE3 1 ATOM 3999 C CZ2 . TRP B 1 97 ? -26.760 -57.333 24.044 1.00 62.67 ? 70 TRP A CZ2 1 ATOM 4000 C CZ3 . TRP B 1 97 ? -25.721 -55.207 23.568 1.00 58.88 ? 70 TRP A CZ3 1 ATOM 4001 C CH2 . TRP B 1 97 ? -26.583 -56.010 24.330 1.00 60.94 ? 70 TRP A CH2 1 ATOM 4002 N N . LEU B 1 98 ? -21.000 -57.597 18.559 1.00 54.22 ? 71 LEU A N 1 ATOM 4003 C CA . LEU B 1 98 ? -20.111 -57.130 17.536 1.00 57.78 ? 71 LEU A CA 1 ATOM 4004 C C . LEU B 1 98 ? -19.734 -58.276 16.577 1.00 60.63 ? 71 LEU A C 1 ATOM 4005 O O . LEU B 1 98 ? -19.565 -58.044 15.362 1.00 54.14 ? 71 LEU A O 1 ATOM 4006 C CB . LEU B 1 98 ? -18.880 -56.497 18.169 1.00 62.59 ? 71 LEU A CB 1 ATOM 4007 C CG . LEU B 1 98 ? -17.708 -56.285 17.210 1.00 68.13 ? 71 LEU A CG 1 ATOM 4008 C CD1 . LEU B 1 98 ? -16.743 -55.272 17.810 1.00 71.61 ? 71 LEU A CD1 1 ATOM 4009 C CD2 . LEU B 1 98 ? -16.973 -57.590 16.944 1.00 67.50 ? 71 LEU A CD2 1 ATOM 4010 N N . GLN B 1 99 ? -19.595 -59.498 17.112 1.00 61.66 ? 72 GLN A N 1 ATOM 4011 C CA . GLN B 1 99 ? -19.255 -60.677 16.274 1.00 66.37 ? 72 GLN A CA 1 ATOM 4012 C C . GLN B 1 99 ? -20.367 -60.976 15.257 1.00 65.75 ? 72 GLN A C 1 ATOM 4013 O O . GLN B 1 99 ? -20.073 -61.216 14.077 1.00 62.14 ? 72 GLN A O 1 ATOM 4014 C CB . GLN B 1 99 ? -18.933 -61.933 17.107 1.00 65.11 ? 72 GLN A CB 1 ATOM 4015 C CG . GLN B 1 99 ? -17.604 -61.910 17.848 1.00 68.49 ? 72 GLN A CG 1 ATOM 4016 C CD . GLN B 1 99 ? -16.440 -62.411 17.015 1.00 74.97 ? 72 GLN A CD 1 ATOM 4017 O OE1 . GLN B 1 99 ? -15.819 -63.420 17.352 1.00 84.88 ? 72 GLN A OE1 1 ATOM 4018 N NE2 . GLN B 1 99 ? -16.139 -61.716 15.923 1.00 71.29 ? 72 GLN A NE2 1 ATOM 4019 N N . ALA B 1 100 ? -21.623 -60.933 15.717 1.00 63.07 ? 73 ALA A N 1 ATOM 4020 C CA . ALA B 1 100 ? -22.797 -61.076 14.842 1.00 62.18 ? 73 ALA A CA 1 ATOM 4021 C C . ALA B 1 100 ? -22.756 -60.127 13.646 1.00 61.67 ? 73 ALA A C 1 ATOM 4022 O O . ALA B 1 100 ? -23.189 -60.480 12.544 1.00 54.38 ? 73 ALA A O 1 ATOM 4023 C CB . ALA B 1 100 ? -24.071 -60.838 15.629 1.00 63.03 ? 73 ALA A CB 1 ATOM 4024 N N . MET B 1 101 ? -22.249 -58.918 13.867 1.00 62.26 ? 74 MET A N 1 ATOM 4025 C CA . MET B 1 101 ? -22.153 -57.954 12.778 1.00 68.88 ? 74 MET A CA 1 ATOM 4026 C C . MET B 1 101 ? -21.137 -58.403 11.752 1.00 66.81 ? 74 MET A C 1 ATOM 4027 O O . MET B 1 101 ? -21.416 -58.376 10.568 1.00 69.62 ? 74 MET A O 1 ATOM 4028 C CB . MET B 1 101 ? -21.747 -56.557 13.264 1.00 67.52 ? 74 MET A CB 1 ATOM 4029 C CG . MET B 1 101 ? -21.457 -55.617 12.100 1.00 68.05 ? 74 MET A CG 1 ATOM 4030 S SD . MET B 1 101 ? -21.449 -53.891 12.549 1.00 70.78 ? 74 MET A SD 1 ATOM 4031 C CE . MET B 1 101 ? -20.654 -53.115 11.155 1.00 66.37 ? 74 MET A CE 1 ATOM 4032 N N . ILE B 1 102 ? -19.949 -58.763 12.226 1.00 70.94 ? 75 ILE A N 1 ATOM 4033 C CA . ILE B 1 102 ? -18.862 -59.183 11.364 1.00 69.65 ? 75 ILE A CA 1 ATOM 4034 C C . ILE B 1 102 ? -19.294 -60.437 10.611 1.00 76.37 ? 75 ILE A C 1 ATOM 4035 O O . ILE B 1 102 ? -19.043 -60.537 9.395 1.00 75.16 ? 75 ILE A O 1 ATOM 4036 C CB . ILE B 1 102 ? -17.582 -59.474 12.169 1.00 74.70 ? 75 ILE A CB 1 ATOM 4037 C CG1 . ILE B 1 102 ? -17.065 -58.195 12.836 1.00 79.89 ? 75 ILE A CG1 1 ATOM 4038 C CG2 . ILE B 1 102 ? -16.494 -60.029 11.259 1.00 79.33 ? 75 ILE A CG2 1 ATOM 4039 C CD1 . ILE B 1 102 ? -15.847 -58.399 13.720 1.00 79.51 ? 75 ILE A CD1 1 ATOM 4040 N N . PHE B 1 103 ? -19.953 -61.366 11.331 1.00 69.30 ? 76 PHE A N 1 ATOM 4041 C CA . PHE B 1 103 ? -20.478 -62.606 10.743 1.00 69.50 ? 76 PHE A CA 1 ATOM 4042 C C . PHE B 1 103 ? -21.378 -62.301 9.569 1.00 67.08 ? 76 PHE A C 1 ATOM 4043 O O . PHE B 1 103 ? -21.209 -62.839 8.485 1.00 70.18 ? 76 PHE A O 1 ATOM 4044 C CB . PHE B 1 103 ? -21.274 -63.419 11.768 1.00 70.31 ? 76 PHE A CB 1 ATOM 4045 C CG . PHE B 1 103 ? -21.774 -64.742 11.244 1.00 78.33 ? 76 PHE A CG 1 ATOM 4046 C CD1 . PHE B 1 103 ? -20.971 -65.880 11.304 1.00 77.76 ? 76 PHE A CD1 1 ATOM 4047 C CD2 . PHE B 1 103 ? -23.052 -64.858 10.693 1.00 82.74 ? 76 PHE A CD2 1 ATOM 4048 C CE1 . PHE B 1 103 ? -21.428 -67.095 10.829 1.00 75.56 ? 76 PHE A CE1 1 ATOM 4049 C CE2 . PHE B 1 103 ? -23.513 -66.076 10.212 1.00 80.49 ? 76 PHE A CE2 1 ATOM 4050 C CZ . PHE B 1 103 ? -22.701 -67.193 10.280 1.00 75.49 ? 76 PHE A CZ 1 ATOM 4051 N N . ALA B 1 104 ? -22.341 -61.428 9.797 1.00 68.14 ? 77 ALA A N 1 ATOM 4052 C CA . ALA B 1 104 ? -23.351 -61.164 8.802 1.00 69.28 ? 77 ALA A CA 1 ATOM 4053 C C . ALA B 1 104 ? -22.712 -60.558 7.573 1.00 70.74 ? 77 ALA A C 1 ATOM 4054 O O . ALA B 1 104 ? -23.190 -60.794 6.470 1.00 72.11 ? 77 ALA A O 1 ATOM 4055 C CB . ALA B 1 104 ? -24.412 -60.244 9.365 1.00 68.48 ? 77 ALA A CB 1 ATOM 4056 N N . ILE B 1 105 ? -21.631 -59.802 7.762 1.00 66.67 ? 78 ILE A N 1 ATOM 4057 C CA . ILE B 1 105 ? -20.953 -59.135 6.650 1.00 73.48 ? 78 ILE A CA 1 ATOM 4058 C C . ILE B 1 105 ? -20.173 -60.120 5.796 1.00 75.87 ? 78 ILE A C 1 ATOM 4059 O O . ILE B 1 105 ? -20.254 -60.071 4.573 1.00 82.48 ? 78 ILE A O 1 ATOM 4060 C CB . ILE B 1 105 ? -20.011 -57.999 7.126 1.00 70.88 ? 78 ILE A CB 1 ATOM 4061 C CG1 . ILE B 1 105 ? -20.832 -56.781 7.547 1.00 68.06 ? 78 ILE A CG1 1 ATOM 4062 C CG2 . ILE B 1 105 ? -19.038 -57.565 6.035 1.00 66.21 ? 78 ILE A CG2 1 ATOM 4063 C CD1 . ILE B 1 105 ? -20.064 -55.826 8.445 1.00 67.16 ? 78 ILE A CD1 1 ATOM 4064 N N . GLU B 1 106 ? -19.409 -61.000 6.426 1.00 82.25 ? 79 GLU A N 1 ATOM 4065 C CA . GLU B 1 106 ? -18.639 -61.980 5.665 1.00 84.09 ? 79 GLU A CA 1 ATOM 4066 C C . GLU B 1 106 ? -19.597 -62.902 4.899 1.00 84.82 ? 79 GLU A C 1 ATOM 4067 O O . GLU B 1 106 ? -19.528 -62.996 3.678 1.00 94.62 ? 79 GLU A O 1 ATOM 4068 C CB . GLU B 1 106 ? -17.629 -62.704 6.564 1.00 85.17 ? 79 GLU A CB 1 ATOM 4069 C CG . GLU B 1 106 ? -16.317 -61.912 6.632 1.00 94.88 ? 79 GLU A CG 1 ATOM 4070 C CD . GLU B 1 106 ? -15.442 -62.142 7.870 1.00 97.18 ? 79 GLU A CD 1 ATOM 4071 O OE1 . GLU B 1 106 ? -15.658 -63.107 8.646 1.00 93.42 ? 79 GLU A OE1 1 ATOM 4072 O OE2 . GLU B 1 106 ? -14.503 -61.324 8.054 1.00 100.57 ? 79 GLU A OE2 1 ATOM 4073 N N . GLU B 1 107 ? -20.553 -63.497 5.593 1.00 82.44 ? 80 GLU A N 1 ATOM 4074 C CA . GLU B 1 107 ? -21.664 -64.205 4.934 1.00 80.99 ? 80 GLU A CA 1 ATOM 4075 C C . GLU B 1 107 ? -22.262 -63.481 3.703 1.00 81.26 ? 80 GLU A C 1 ATOM 4076 O O . GLU B 1 107 ? -22.638 -64.112 2.721 1.00 91.47 ? 80 GLU A O 1 ATOM 4077 C CB . GLU B 1 107 ? -22.776 -64.484 5.958 1.00 74.00 ? 80 GLU A CB 1 ATOM 4078 C CG . GLU B 1 107 ? -23.987 -65.220 5.398 1.00 72.37 ? 80 GLU A CG 1 ATOM 4079 C CD . GLU B 1 107 ? -24.909 -65.722 6.495 1.00 74.33 ? 80 GLU A CD 1 ATOM 4080 O OE1 . GLU B 1 107 ? -26.130 -65.420 6.442 1.00 65.53 ? 80 GLU A OE1 1 ATOM 4081 O OE2 . GLU B 1 107 ? -24.400 -66.396 7.424 1.00 75.39 ? 80 GLU A OE2 1 ATOM 4082 N N . ILE B 1 108 ? -22.383 -62.167 3.771 1.00 87.38 ? 81 ILE A N 1 ATOM 4083 C CA . ILE B 1 108 ? -22.997 -61.404 2.688 1.00 88.90 ? 81 ILE A CA 1 ATOM 4084 C C . ILE B 1 108 ? -22.012 -61.221 1.543 1.00 88.74 ? 81 ILE A C 1 ATOM 4085 O O . ILE B 1 108 ? -22.390 -61.188 0.366 1.00 87.86 ? 81 ILE A O 1 ATOM 4086 C CB . ILE B 1 108 ? -23.540 -60.057 3.206 1.00 85.14 ? 81 ILE A CB 1 ATOM 4087 C CG1 . ILE B 1 108 ? -24.857 -60.310 3.941 1.00 87.23 ? 81 ILE A CG1 1 ATOM 4088 C CG2 . ILE B 1 108 ? -23.766 -59.061 2.074 1.00 79.73 ? 81 ILE A CG2 1 ATOM 4089 C CD1 . ILE B 1 108 ? -25.309 -59.137 4.777 1.00 90.50 ? 81 ILE A CD1 1 ATOM 4090 N N . ASN B 1 109 ? -20.745 -61.107 1.892 1.00 84.71 ? 82 ASN A N 1 ATOM 4091 C CA . ASN B 1 109 ? -19.715 -61.106 0.886 1.00 87.28 ? 82 ASN A CA 1 ATOM 4092 C C . ASN B 1 109 ? -19.602 -62.488 0.211 1.00 92.70 ? 82 ASN A C 1 ATOM 4093 O O . ASN B 1 109 ? -19.534 -62.580 -1.030 1.00 87.85 ? 82 ASN A O 1 ATOM 4094 C CB . ASN B 1 109 ? -18.415 -60.608 1.505 1.00 79.18 ? 82 ASN A CB 1 ATOM 4095 C CG . ASN B 1 109 ? -18.429 -59.108 1.689 1.00 78.83 ? 82 ASN A CG 1 ATOM 4096 O OD1 . ASN B 1 109 ? -19.174 -58.405 1.000 1.00 78.65 ? 82 ASN A OD1 1 ATOM 4097 N ND2 . ASN B 1 109 ? -17.618 -58.605 2.606 1.00 77.97 ? 82 ASN A ND2 1 ATOM 4098 N N . SER B 1 110 ? -19.650 -63.542 1.029 1.00 86.18 ? 83 SER A N 1 ATOM 4099 C CA . SER B 1 110 ? -19.702 -64.929 0.553 1.00 81.72 ? 83 SER A CA 1 ATOM 4100 C C . SER B 1 110 ? -20.897 -65.213 -0.339 1.00 84.64 ? 83 SER A C 1 ATOM 4101 O O . SER B 1 110 ? -20.811 -66.034 -1.226 1.00 88.44 ? 83 SER A O 1 ATOM 4102 C CB . SER B 1 110 ? -19.753 -65.901 1.733 1.00 77.62 ? 83 SER A CB 1 ATOM 4103 O OG . SER B 1 110 ? -18.538 -65.880 2.461 1.00 74.49 ? 83 SER A OG 1 ATOM 4104 N N . SER B 1 111 ? -22.028 -64.570 -0.090 1.00 98.03 ? 84 SER A N 1 ATOM 4105 C CA . SER B 1 111 ? -23.173 -64.777 -0.958 1.00 107.61 ? 84 SER A CA 1 ATOM 4106 C C . SER B 1 111 ? -22.871 -64.152 -2.320 1.00 109.06 ? 84 SER A C 1 ATOM 4107 O O . SER B 1 111 ? -22.502 -62.981 -2.412 1.00 111.88 ? 84 SER A O 1 ATOM 4108 C CB . SER B 1 111 ? -24.454 -64.195 -0.364 1.00 110.05 ? 84 SER A CB 1 ATOM 4109 O OG . SER B 1 111 ? -25.573 -64.588 -1.139 1.00 114.58 ? 84 SER A OG 1 ATOM 4110 N N . PRO B 1 112 ? -22.985 -64.951 -3.383 1.00 116.42 ? 85 PRO A N 1 ATOM 4111 C CA . PRO B 1 112 ? -22.799 -64.391 -4.718 1.00 115.15 ? 85 PRO A CA 1 ATOM 4112 C C . PRO B 1 112 ? -24.004 -63.545 -5.141 1.00 116.37 ? 85 PRO A C 1 ATOM 4113 O O . PRO B 1 112 ? -23.820 -62.471 -5.730 1.00 95.82 ? 85 PRO A O 1 ATOM 4114 C CB . PRO B 1 112 ? -22.678 -65.635 -5.594 1.00 117.30 ? 85 PRO A CB 1 ATOM 4115 C CG . PRO B 1 112 ? -23.440 -66.705 -4.866 1.00 113.07 ? 85 PRO A CG 1 ATOM 4116 C CD . PRO B 1 112 ? -23.336 -66.388 -3.406 1.00 109.90 ? 85 PRO A CD 1 ATOM 4117 N N . ALA B 1 113 ? -25.204 -64.046 -4.805 1.00 117.49 ? 86 ALA A N 1 ATOM 4118 C CA . ALA B 1 113 ? -26.507 -63.458 -5.151 1.00 122.36 ? 86 ALA A CA 1 ATOM 4119 C C . ALA B 1 113 ? -26.675 -62.028 -4.653 1.00 131.80 ? 86 ALA A C 1 ATOM 4120 O O . ALA B 1 113 ? -27.026 -61.122 -5.416 1.00 131.91 ? 86 ALA A O 1 ATOM 4121 C CB . ALA B 1 113 ? -27.624 -64.319 -4.567 1.00 119.20 ? 86 ALA A CB 1 ATOM 4122 N N . LEU B 1 114 ? -26.433 -61.845 -3.359 1.00 128.74 ? 87 LEU A N 1 ATOM 4123 C CA . LEU B 1 114 ? -26.557 -60.544 -2.706 1.00 107.61 ? 87 LEU A CA 1 ATOM 4124 C C . LEU B 1 114 ? -25.306 -59.674 -2.946 1.00 100.89 ? 87 LEU A C 1 ATOM 4125 O O . LEU B 1 114 ? -24.199 -60.019 -2.516 1.00 91.37 ? 87 LEU A O 1 ATOM 4126 C CB . LEU B 1 114 ? -26.785 -60.762 -1.210 1.00 99.42 ? 87 LEU A CB 1 ATOM 4127 C CG . LEU B 1 114 ? -27.489 -59.632 -0.482 1.00 99.24 ? 87 LEU A CG 1 ATOM 4128 C CD1 . LEU B 1 114 ? -28.952 -59.590 -0.893 1.00 103.69 ? 87 LEU A CD1 1 ATOM 4129 C CD2 . LEU B 1 114 ? -27.343 -59.793 1.026 1.00 100.72 ? 87 LEU A CD2 1 ATOM 4130 N N . LEU B 1 115 ? -25.494 -58.552 -3.639 1.00 100.13 ? 88 LEU A N 1 ATOM 4131 C CA . LEU B 1 115 ? -24.403 -57.632 -3.966 1.00 103.38 ? 88 LEU A CA 1 ATOM 4132 C C . LEU B 1 115 ? -23.209 -58.344 -4.596 1.00 109.61 ? 88 LEU A C 1 ATOM 4133 O O . LEU B 1 115 ? -22.221 -58.641 -3.916 1.00 112.05 ? 88 LEU A O 1 ATOM 4134 C CB . LEU B 1 115 ? -23.947 -56.862 -2.726 1.00 100.29 ? 88 LEU A CB 1 ATOM 4135 C CG . LEU B 1 115 ? -24.973 -55.918 -2.102 1.00 100.44 ? 88 LEU A CG 1 ATOM 4136 C CD1 . LEU B 1 115 ? -24.335 -55.169 -0.940 1.00 96.81 ? 88 LEU A CD1 1 ATOM 4137 C CD2 . LEU B 1 115 ? -25.538 -54.950 -3.132 1.00 97.69 ? 88 LEU A CD2 1 ATOM 4138 N N . PRO B 1 116 ? -23.303 -58.631 -5.899 1.00 113.57 ? 89 PRO A N 1 ATOM 4139 C CA . PRO B 1 116 ? -22.218 -59.351 -6.570 1.00 118.66 ? 89 PRO A CA 1 ATOM 4140 C C . PRO B 1 116 ? -20.994 -58.492 -6.911 1.00 108.76 ? 89 PRO A C 1 ATOM 4141 O O . PRO B 1 116 ? -19.875 -58.875 -6.581 1.00 105.86 ? 89 PRO A O 1 ATOM 4142 C CB . PRO B 1 116 ? -22.884 -59.916 -7.831 1.00 118.60 ? 89 PRO A CB 1 ATOM 4143 C CG . PRO B 1 116 ? -24.104 -59.097 -8.037 1.00 116.87 ? 89 PRO A CG 1 ATOM 4144 C CD . PRO B 1 116 ? -24.534 -58.576 -6.705 1.00 112.56 ? 89 PRO A CD 1 ATOM 4145 N N . ASN B 1 117 ? -21.191 -57.341 -7.543 1.00 102.73 ? 90 ASN A N 1 ATOM 4146 C CA . ASN B 1 117 ? -20.050 -56.519 -7.948 1.00 105.38 ? 90 ASN A CA 1 ATOM 4147 C C . ASN B 1 117 ? -19.160 -56.040 -6.779 1.00 107.50 ? 90 ASN A C 1 ATOM 4148 O O . ASN B 1 117 ? -17.984 -55.733 -6.989 1.00 104.93 ? 90 ASN A O 1 ATOM 4149 C CB . ASN B 1 117 ? -20.526 -55.312 -8.770 1.00 103.84 ? 90 ASN A CB 1 ATOM 4150 N N . LEU B 1 118 ? -19.705 -56.008 -5.558 1.00 104.30 ? 91 LEU A N 1 ATOM 4151 C CA . LEU B 1 118 ? -19.124 -55.225 -4.454 1.00 97.62 ? 91 LEU A CA 1 ATOM 4152 C C . LEU B 1 118 ? -18.823 -56.012 -3.182 1.00 85.36 ? 91 LEU A C 1 ATOM 4153 O O . LEU B 1 118 ? -19.440 -57.045 -2.921 1.00 72.65 ? 91 LEU A O 1 ATOM 4154 C CB . LEU B 1 118 ? -20.102 -54.113 -4.091 1.00 108.49 ? 91 LEU A CB 1 ATOM 4155 C CG . LEU B 1 118 ? -20.755 -53.415 -5.293 1.00 125.31 ? 91 LEU A CG 1 ATOM 4156 C CD1 . LEU B 1 118 ? -21.842 -52.451 -4.842 1.00 123.81 ? 91 LEU A CD1 1 ATOM 4157 C CD2 . LEU B 1 118 ? -19.705 -52.688 -6.129 1.00 135.75 ? 91 LEU A CD2 1 ATOM 4158 N N . THR B 1 119 ? -17.876 -55.513 -2.390 1.00 80.13 ? 92 THR A N 1 ATOM 4159 C CA . THR B 1 119 ? -17.671 -56.009 -1.018 1.00 92.95 ? 92 THR A CA 1 ATOM 4160 C C . THR B 1 119 ? -18.057 -54.954 0.021 1.00 90.87 ? 92 THR A C 1 ATOM 4161 O O . THR B 1 119 ? -17.847 -53.744 -0.175 1.00 80.96 ? 92 THR A O 1 ATOM 4162 C CB . THR B 1 119 ? -16.211 -56.427 -0.697 1.00 95.45 ? 92 THR A CB 1 ATOM 4163 O OG1 . THR B 1 119 ? -15.320 -55.356 -1.032 1.00 107.06 ? 92 THR A OG1 1 ATOM 4164 C CG2 . THR B 1 119 ? -15.807 -57.727 -1.427 1.00 93.92 ? 92 THR A CG2 1 ATOM 4165 N N . LEU B 1 120 ? -18.604 -55.449 1.131 1.00 82.69 ? 93 LEU A N 1 ATOM 4166 C CA . LEU B 1 120 ? -18.902 -54.639 2.292 1.00 79.54 ? 93 LEU A CA 1 ATOM 4167 C C . LEU B 1 120 ? -17.747 -54.658 3.267 1.00 75.81 ? 93 LEU A C 1 ATOM 4168 O O . LEU B 1 120 ? -17.287 -55.720 3.640 1.00 74.06 ? 93 LEU A O 1 ATOM 4169 C CB . LEU B 1 120 ? -20.117 -55.202 3.012 1.00 79.79 ? 93 LEU A CB 1 ATOM 4170 C CG . LEU B 1 120 ? -21.423 -55.099 2.247 1.00 78.55 ? 93 LEU A CG 1 ATOM 4171 C CD1 . LEU B 1 120 ? -22.525 -55.636 3.132 1.00 77.93 ? 93 LEU A CD1 1 ATOM 4172 C CD2 . LEU B 1 120 ? -21.714 -53.667 1.823 1.00 81.92 ? 93 LEU A CD2 1 ATOM 4173 N N . GLY B 1 121 ? -17.306 -53.483 3.700 1.00 79.81 ? 94 GLY A N 1 ATOM 4174 C CA . GLY B 1 121 ? -16.328 -53.366 4.783 1.00 80.18 ? 94 GLY A CA 1 ATOM 4175 C C . GLY B 1 121 ? -16.948 -52.867 6.084 1.00 79.40 ? 94 GLY A C 1 ATOM 4176 O O . GLY B 1 121 ? -18.154 -52.613 6.166 1.00 73.86 ? 94 GLY A O 1 ATOM 4177 N N . TYR B 1 122 ? -16.112 -52.713 7.103 1.00 76.15 ? 95 TYR A N 1 ATOM 4178 C CA . TYR B 1 122 ? -16.587 -52.287 8.395 1.00 74.43 ? 95 TYR A CA 1 ATOM 4179 C C . TYR B 1 122 ? -15.535 -51.588 9.239 1.00 77.35 ? 95 TYR A C 1 ATOM 4180 O O . TYR B 1 122 ? -14.384 -52.005 9.249 1.00 80.21 ? 95 TYR A O 1 ATOM 4181 C CB . TYR B 1 122 ? -17.155 -53.486 9.154 1.00 77.24 ? 95 TYR A CB 1 ATOM 4182 C CG . TYR B 1 122 ? -16.227 -54.675 9.382 1.00 77.09 ? 95 TYR A CG 1 ATOM 4183 C CD1 . TYR B 1 122 ? -15.211 -54.634 10.343 1.00 79.57 ? 95 TYR A CD1 1 ATOM 4184 C CD2 . TYR B 1 122 ? -16.421 -55.874 8.693 1.00 74.99 ? 95 TYR A CD2 1 ATOM 4185 C CE1 . TYR B 1 122 ? -14.388 -55.728 10.578 1.00 79.00 ? 95 TYR A CE1 1 ATOM 4186 C CE2 . TYR B 1 122 ? -15.611 -56.975 8.929 1.00 76.11 ? 95 TYR A CE2 1 ATOM 4187 C CZ . TYR B 1 122 ? -14.592 -56.897 9.867 1.00 80.84 ? 95 TYR A CZ 1 ATOM 4188 O OH . TYR B 1 122 ? -13.782 -57.996 10.096 1.00 85.65 ? 95 TYR A OH 1 ATOM 4189 N N . ARG B 1 123 ? -15.940 -50.510 9.917 1.00 74.47 ? 96 ARG A N 1 ATOM 4190 C CA . ARG B 1 123 ? -15.147 -49.875 10.972 1.00 73.13 ? 96 ARG A CA 1 ATOM 4191 C C . ARG B 1 123 ? -16.025 -49.865 12.232 1.00 72.31 ? 96 ARG A C 1 ATOM 4192 O O . ARG B 1 123 ? -17.108 -49.273 12.248 1.00 70.02 ? 96 ARG A O 1 ATOM 4193 C CB . ARG B 1 123 ? -14.731 -48.451 10.574 1.00 79.74 ? 96 ARG A CB 1 ATOM 4194 C CG . ARG B 1 123 ? -13.559 -48.390 9.603 1.00 90.80 ? 96 ARG A CG 1 ATOM 4195 C CD . ARG B 1 123 ? -13.554 -47.121 8.752 1.00 97.17 ? 96 ARG A CD 1 ATOM 4196 N NE . ARG B 1 123 ? -13.595 -45.906 9.571 1.00 105.01 ? 96 ARG A NE 1 ATOM 4197 C CZ . ARG B 1 123 ? -14.143 -44.746 9.197 1.00 101.94 ? 96 ARG A CZ 1 ATOM 4198 N NH1 . ARG B 1 123 ? -14.728 -44.612 8.003 1.00 101.27 ? 96 ARG A NH1 1 ATOM 4199 N NH2 . ARG B 1 123 ? -14.125 -43.711 10.034 1.00 91.19 ? 96 ARG A NH2 1 ATOM 4200 N N . ILE B 1 124 ? -15.547 -50.513 13.289 1.00 64.96 ? 97 ILE A N 1 ATOM 4201 C CA . ILE B 1 124 ? -16.373 -50.842 14.428 1.00 57.33 ? 97 ILE A CA 1 ATOM 4202 C C . ILE B 1 124 ? -15.712 -50.465 15.749 1.00 59.13 ? 97 ILE A C 1 ATOM 4203 O O . ILE B 1 124 ? -14.701 -51.027 16.119 1.00 61.23 ? 97 ILE A O 1 ATOM 4204 C CB . ILE B 1 124 ? -16.685 -52.346 14.441 1.00 54.21 ? 97 ILE A CB 1 ATOM 4205 C CG1 . ILE B 1 124 ? -17.428 -52.728 13.179 1.00 52.26 ? 97 ILE A CG1 1 ATOM 4206 C CG2 . ILE B 1 124 ? -17.557 -52.703 15.634 1.00 60.97 ? 97 ILE A CG2 1 ATOM 4207 C CD1 . ILE B 1 124 ? -17.926 -54.151 13.192 1.00 54.37 ? 97 ILE A CD1 1 ATOM 4208 N N . PHE B 1 125 ? -16.326 -49.552 16.492 1.00 60.78 ? 98 PHE A N 1 ATOM 4209 C CA . PHE B 1 125 ? -15.756 -49.088 17.735 1.00 57.88 ? 98 PHE A CA 1 ATOM 4210 C C . PHE B 1 125 ? -16.526 -49.576 18.964 1.00 52.60 ? 98 PHE A C 1 ATOM 4211 O O . PHE B 1 125 ? -17.591 -50.118 18.850 1.00 55.53 ? 98 PHE A O 1 ATOM 4212 C CB . PHE B 1 125 ? -15.698 -47.555 17.734 1.00 58.38 ? 98 PHE A CB 1 ATOM 4213 C CG . PHE B 1 125 ? -14.943 -46.971 16.587 1.00 59.64 ? 98 PHE A CG 1 ATOM 4214 C CD1 . PHE B 1 125 ? -13.574 -46.738 16.684 1.00 66.59 ? 98 PHE A CD1 1 ATOM 4215 C CD2 . PHE B 1 125 ? -15.595 -46.611 15.411 1.00 61.50 ? 98 PHE A CD2 1 ATOM 4216 C CE1 . PHE B 1 125 ? -12.870 -46.170 15.618 1.00 65.28 ? 98 PHE A CE1 1 ATOM 4217 C CE2 . PHE B 1 125 ? -14.893 -46.036 14.344 1.00 58.14 ? 98 PHE A CE2 1 ATOM 4218 C CZ . PHE B 1 125 ? -13.537 -45.816 14.448 1.00 57.25 ? 98 PHE A CZ 1 ATOM 4219 N N . ASP B 1 126 ? -15.923 -49.336 20.127 1.00 59.66 ? 99 ASP A N 1 ATOM 4220 C CA . ASP B 1 126 ? -16.443 -49.585 21.468 1.00 57.18 ? 99 ASP A CA 1 ATOM 4221 C C . ASP B 1 126 ? -16.990 -48.262 22.036 1.00 55.07 ? 99 ASP A C 1 ATOM 4222 O O . ASP B 1 126 ? -16.301 -47.268 22.068 1.00 56.43 ? 99 ASP A O 1 ATOM 4223 C CB . ASP B 1 126 ? -15.284 -50.102 22.366 1.00 53.57 ? 99 ASP A CB 1 ATOM 4224 C CG . ASP B 1 126 ? -15.717 -50.430 23.820 1.00 63.30 ? 99 ASP A CG 1 ATOM 4225 O OD1 . ASP B 1 126 ? -16.938 -50.385 24.142 1.00 73.39 ? 99 ASP A OD1 1 ATOM 4226 O OD2 . ASP B 1 126 ? -14.827 -50.741 24.668 1.00 62.79 ? 99 ASP A OD2 1 ATOM 4227 N N . THR B 1 127 ? -18.220 -48.268 22.520 1.00 59.93 ? 100 THR A N 1 ATOM 4228 C CA . THR B 1 127 ? -18.799 -47.099 23.193 1.00 59.88 ? 100 THR A CA 1 ATOM 4229 C C . THR B 1 127 ? -18.585 -47.080 24.702 1.00 57.50 ? 100 THR A C 1 ATOM 4230 O O . THR B 1 127 ? -18.774 -46.044 25.338 1.00 56.48 ? 100 THR A O 1 ATOM 4231 C CB . THR B 1 127 ? -20.308 -47.096 23.013 1.00 55.80 ? 100 THR A CB 1 ATOM 4232 O OG1 . THR B 1 127 ? -20.823 -48.329 23.538 1.00 54.65 ? 100 THR A OG1 1 ATOM 4233 C CG2 . THR B 1 127 ? -20.656 -46.960 21.552 1.00 53.61 ? 100 THR A CG2 1 ATOM 4234 N N . CYS B 1 128 ? -18.256 -48.227 25.278 1.00 55.65 ? 101 CYS A N 1 ATOM 4235 C CA . CYS B 1 128 ? -18.204 -48.366 26.727 1.00 60.92 ? 101 CYS A CA 1 ATOM 4236 C C . CYS B 1 128 ? -19.497 -47.903 27.414 1.00 57.85 ? 101 CYS A C 1 ATOM 4237 O O . CYS B 1 128 ? -19.442 -47.494 28.566 1.00 59.25 ? 101 CYS A O 1 ATOM 4238 C CB . CYS B 1 128 ? -16.983 -47.621 27.284 1.00 63.29 ? 101 CYS A CB 1 ATOM 4239 S SG . CYS B 1 128 ? -15.513 -48.197 26.400 1.00 79.55 ? 101 CYS A SG 1 ATOM 4240 N N . ASN B 1 129 ? -20.644 -48.017 26.722 1.00 52.79 ? 102 ASN A N 1 ATOM 4241 C CA . ASN B 1 129 ? -21.937 -47.404 27.140 1.00 55.73 ? 102 ASN A CA 1 ATOM 4242 C C . ASN B 1 129 ? -21.834 -45.909 27.462 1.00 49.78 ? 102 ASN A C 1 ATOM 4243 O O . ASN B 1 129 ? -22.466 -45.464 28.385 1.00 53.38 ? 102 ASN A O 1 ATOM 4244 C CB . ASN B 1 129 ? -22.575 -48.071 28.382 1.00 53.34 ? 102 ASN A CB 1 ATOM 4245 C CG . ASN B 1 129 ? -23.034 -49.483 28.137 1.00 59.00 ? 102 ASN A CG 1 ATOM 4246 O OD1 . ASN B 1 129 ? -23.756 -49.778 27.179 1.00 55.54 ? 102 ASN A OD1 1 ATOM 4247 N ND2 . ASN B 1 129 ? -22.632 -50.378 29.034 1.00 67.67 ? 102 ASN A ND2 1 ATOM 4248 N N . THR B 1 130 ? -21.058 -45.156 26.700 1.00 46.57 ? 103 THR A N 1 ATOM 4249 C CA . THR B 1 130 ? -20.708 -43.788 27.059 1.00 49.44 ? 103 THR A CA 1 ATOM 4250 C C . THR B 1 130 ? -20.962 -42.889 25.843 1.00 50.12 ? 103 THR A C 1 ATOM 4251 O O . THR B 1 130 ? -20.607 -43.225 24.711 1.00 51.66 ? 103 THR A O 1 ATOM 4252 C CB . THR B 1 130 ? -19.241 -43.707 27.571 1.00 53.81 ? 103 THR A CB 1 ATOM 4253 O OG1 . THR B 1 130 ? -19.170 -44.170 28.921 1.00 56.23 ? 103 THR A OG1 1 ATOM 4254 C CG2 . THR B 1 130 ? -18.696 -42.325 27.581 1.00 60.04 ? 103 THR A CG2 1 ATOM 4255 N N . VAL B 1 131 ? -21.617 -41.757 26.085 1.00 48.89 ? 104 VAL A N 1 ATOM 4256 C CA . VAL B 1 131 ? -21.840 -40.795 25.027 1.00 49.22 ? 104 VAL A CA 1 ATOM 4257 C C . VAL B 1 131 ? -20.507 -40.378 24.465 1.00 47.54 ? 104 VAL A C 1 ATOM 4258 O O . VAL B 1 131 ? -20.339 -40.390 23.259 1.00 50.51 ? 104 VAL A O 1 ATOM 4259 C CB . VAL B 1 131 ? -22.626 -39.559 25.503 1.00 48.03 ? 104 VAL A CB 1 ATOM 4260 C CG1 . VAL B 1 131 ? -22.619 -38.482 24.455 1.00 47.29 ? 104 VAL A CG1 1 ATOM 4261 C CG2 . VAL B 1 131 ? -24.056 -39.950 25.789 1.00 50.71 ? 104 VAL A CG2 1 ATOM 4262 N N . SER B 1 132 ? -19.564 -40.035 25.338 1.00 45.93 ? 105 SER A N 1 ATOM 4263 C CA . SER B 1 132 ? -18.313 -39.476 24.879 1.00 49.84 ? 105 SER A CA 1 ATOM 4264 C C . SER B 1 132 ? -17.594 -40.424 23.915 1.00 50.80 ? 105 SER A C 1 ATOM 4265 O O . SER B 1 132 ? -17.271 -40.019 22.820 1.00 51.73 ? 105 SER A O 1 ATOM 4266 C CB . SER B 1 132 ? -17.430 -38.965 26.045 1.00 53.10 ? 105 SER A CB 1 ATOM 4267 O OG . SER B 1 132 ? -16.967 -39.993 26.924 1.00 61.69 ? 105 SER A OG 1 ATOM 4268 N N . LYS B 1 133 ? -17.410 -41.686 24.275 1.00 56.68 ? 106 LYS A N 1 ATOM 4269 C CA . LYS B 1 133 ? -16.702 -42.638 23.402 1.00 59.21 ? 106 LYS A CA 1 ATOM 4270 C C . LYS B 1 133 ? -17.466 -42.843 22.104 1.00 57.93 ? 106 LYS A C 1 ATOM 4271 O O . LYS B 1 133 ? -16.887 -42.845 21.043 1.00 59.52 ? 106 LYS A O 1 ATOM 4272 C CB . LYS B 1 133 ? -16.524 -44.011 24.066 1.00 62.94 ? 106 LYS A CB 1 ATOM 4273 C CG . LYS B 1 133 ? -15.808 -44.036 25.410 1.00 61.51 ? 106 LYS A CG 1 ATOM 4274 C CD . LYS B 1 133 ? -14.313 -43.998 25.274 1.00 69.40 ? 106 LYS A CD 1 ATOM 4275 C CE . LYS B 1 133 ? -13.662 -43.767 26.636 1.00 84.80 ? 106 LYS A CE 1 ATOM 4276 N NZ . LYS B 1 133 ? -12.207 -43.432 26.542 1.00 90.59 ? 106 LYS A NZ 1 ATOM 4277 N N . ALA B 1 134 ? -18.778 -43.001 22.180 1.00 65.71 ? 107 ALA A N 1 ATOM 4278 C CA . ALA B 1 134 ? -19.587 -43.118 20.965 1.00 60.48 ? 107 ALA A CA 1 ATOM 4279 C C . ALA B 1 134 ? -19.452 -41.928 20.044 1.00 61.58 ? 107 ALA A C 1 ATOM 4280 O O . ALA B 1 134 ? -19.494 -42.112 18.839 1.00 67.47 ? 107 ALA A O 1 ATOM 4281 C CB . ALA B 1 134 ? -21.036 -43.312 21.303 1.00 59.68 ? 107 ALA A CB 1 ATOM 4282 N N . LEU B 1 135 ? -19.302 -40.716 20.583 1.00 62.67 ? 108 LEU A N 1 ATOM 4283 C CA . LEU B 1 135 ? -19.158 -39.520 19.732 1.00 61.98 ? 108 LEU A CA 1 ATOM 4284 C C . LEU B 1 135 ? -17.760 -39.361 19.102 1.00 61.99 ? 108 LEU A C 1 ATOM 4285 O O . LEU B 1 135 ? -17.649 -38.894 17.972 1.00 64.18 ? 108 LEU A O 1 ATOM 4286 C CB . LEU B 1 135 ? -19.528 -38.235 20.478 1.00 65.09 ? 108 LEU A CB 1 ATOM 4287 C CG . LEU B 1 135 ? -20.990 -37.792 20.602 1.00 66.95 ? 108 LEU A CG 1 ATOM 4288 C CD1 . LEU B 1 135 ? -21.046 -36.352 21.101 1.00 71.20 ? 108 LEU A CD1 1 ATOM 4289 C CD2 . LEU B 1 135 ? -21.756 -37.889 19.298 1.00 67.52 ? 108 LEU A CD2 1 ATOM 4290 N N . GLU B 1 136 ? -16.697 -39.707 19.825 1.00 58.77 ? 109 GLU A N 1 ATOM 4291 C CA . GLU B 1 136 ? -15.370 -39.755 19.218 1.00 58.11 ? 109 GLU A CA 1 ATOM 4292 C C . GLU B 1 136 ? -15.468 -40.637 17.996 1.00 56.49 ? 109 GLU A C 1 ATOM 4293 O O . GLU B 1 136 ? -15.106 -40.227 16.891 1.00 60.95 ? 109 GLU A O 1 ATOM 4294 C CB . GLU B 1 136 ? -14.318 -40.335 20.169 1.00 65.16 ? 109 GLU A CB 1 ATOM 4295 C CG . GLU B 1 136 ? -13.727 -39.345 21.181 1.00 72.35 ? 109 GLU A CG 1 ATOM 4296 C CD . GLU B 1 136 ? -13.059 -40.016 22.394 1.00 80.24 ? 109 GLU A CD 1 ATOM 4297 O OE1 . GLU B 1 136 ? -12.913 -41.266 22.404 1.00 86.16 ? 109 GLU A OE1 1 ATOM 4298 O OE2 . GLU B 1 136 ? -12.678 -39.295 23.354 1.00 80.09 ? 109 GLU A OE2 1 ATOM 4299 N N . ALA B 1 137 ? -15.970 -41.853 18.191 1.00 53.91 ? 110 ALA A N 1 ATOM 4300 C CA . ALA B 1 137 ? -16.176 -42.801 17.080 1.00 54.61 ? 110 ALA A CA 1 ATOM 4301 C C . ALA B 1 137 ? -16.992 -42.196 15.942 1.00 56.53 ? 110 ALA A C 1 ATOM 4302 O O . ALA B 1 137 ? -16.634 -42.282 14.770 1.00 59.21 ? 110 ALA A O 1 ATOM 4303 C CB . ALA B 1 137 ? -16.858 -44.059 17.593 1.00 53.63 ? 110 ALA A CB 1 ATOM 4304 N N . THR B 1 138 ? -18.090 -41.555 16.305 1.00 57.77 ? 111 THR A N 1 ATOM 4305 C CA . THR B 1 138 ? -18.990 -41.010 15.323 1.00 57.47 ? 111 THR A CA 1 ATOM 4306 C C . THR B 1 138 ? -18.334 -39.918 14.503 1.00 55.72 ? 111 THR A C 1 ATOM 4307 O O . THR B 1 138 ? -18.495 -39.880 13.290 1.00 60.12 ? 111 THR A O 1 ATOM 4308 C CB . THR B 1 138 ? -20.292 -40.529 15.988 1.00 59.28 ? 111 THR A CB 1 ATOM 4309 O OG1 . THR B 1 138 ? -20.999 -41.667 16.513 1.00 58.32 ? 111 THR A OG1 1 ATOM 4310 C CG2 . THR B 1 138 ? -21.179 -39.869 14.982 1.00 61.31 ? 111 THR A CG2 1 ATOM 4311 N N . LEU B 1 139 ? -17.576 -39.041 15.148 1.00 56.00 ? 112 LEU A N 1 ATOM 4312 C CA . LEU B 1 139 ? -16.825 -38.016 14.423 1.00 54.36 ? 112 LEU A CA 1 ATOM 4313 C C . LEU B 1 139 ? -15.924 -38.610 13.355 1.00 55.04 ? 112 LEU A C 1 ATOM 4314 O O . LEU B 1 139 ? -15.790 -38.059 12.282 1.00 57.14 ? 112 LEU A O 1 ATOM 4315 C CB . LEU B 1 139 ? -15.981 -37.197 15.373 1.00 55.82 ? 112 LEU A CB 1 ATOM 4316 C CG . LEU B 1 139 ? -16.805 -36.194 16.154 1.00 56.71 ? 112 LEU A CG 1 ATOM 4317 C CD1 . LEU B 1 139 ? -16.040 -35.704 17.356 1.00 52.45 ? 112 LEU A CD1 1 ATOM 4318 C CD2 . LEU B 1 139 ? -17.202 -35.045 15.232 1.00 59.33 ? 112 LEU A CD2 1 ATOM 4319 N N . SER B 1 140 ? -15.311 -39.743 13.622 1.00 55.89 ? 113 SER A N 1 ATOM 4320 C CA . SER B 1 140 ? -14.547 -40.367 12.561 1.00 59.82 ? 113 SER A CA 1 ATOM 4321 C C . SER B 1 140 ? -15.519 -40.903 11.478 1.00 60.20 ? 113 SER A C 1 ATOM 4322 O O . SER B 1 140 ? -15.266 -40.737 10.291 1.00 63.96 ? 113 SER A O 1 ATOM 4323 C CB . SER B 1 140 ? -13.591 -41.427 13.115 1.00 59.75 ? 113 SER A CB 1 ATOM 4324 O OG . SER B 1 140 ? -14.237 -42.667 13.231 1.00 69.35 ? 113 SER A OG 1 ATOM 4325 N N . PHE B 1 141 ? -16.654 -41.486 11.844 1.00 56.17 ? 114 PHE A N 1 ATOM 4326 C CA . PHE B 1 141 ? -17.602 -41.906 10.793 1.00 57.47 ? 114 PHE A CA 1 ATOM 4327 C C . PHE B 1 141 ? -17.935 -40.804 9.819 1.00 60.41 ? 114 PHE A C 1 ATOM 4328 O O . PHE B 1 141 ? -18.008 -41.048 8.629 1.00 64.15 ? 114 PHE A O 1 ATOM 4329 C CB . PHE B 1 141 ? -18.947 -42.390 11.345 1.00 59.59 ? 114 PHE A CB 1 ATOM 4330 C CG . PHE B 1 141 ? -18.865 -43.651 12.135 1.00 64.40 ? 114 PHE A CG 1 ATOM 4331 C CD1 . PHE B 1 141 ? -17.936 -44.637 11.822 1.00 61.64 ? 114 PHE A CD1 1 ATOM 4332 C CD2 . PHE B 1 141 ? -19.729 -43.855 13.196 1.00 64.95 ? 114 PHE A CD2 1 ATOM 4333 C CE1 . PHE B 1 141 ? -17.872 -45.794 12.551 1.00 64.30 ? 114 PHE A CE1 1 ATOM 4334 C CE2 . PHE B 1 141 ? -19.662 -45.015 13.935 1.00 68.18 ? 114 PHE A CE2 1 ATOM 4335 C CZ . PHE B 1 141 ? -18.730 -45.985 13.612 1.00 67.64 ? 114 PHE A CZ 1 ATOM 4336 N N . VAL B 1 142 ? -18.194 -39.603 10.330 1.00 64.57 ? 115 VAL A N 1 ATOM 4337 C CA . VAL B 1 142 ? -18.630 -38.506 9.466 1.00 61.69 ? 115 VAL A CA 1 ATOM 4338 C C . VAL B 1 142 ? -17.478 -37.660 8.937 1.00 62.19 ? 115 VAL A C 1 ATOM 4339 O O . VAL B 1 142 ? -17.735 -36.588 8.391 1.00 66.59 ? 115 VAL A O 1 ATOM 4340 C CB . VAL B 1 142 ? -19.673 -37.568 10.148 1.00 57.28 ? 115 VAL A CB 1 ATOM 4341 C CG1 . VAL B 1 142 ? -20.885 -38.356 10.581 1.00 56.32 ? 115 VAL A CG1 1 ATOM 4342 C CG2 . VAL B 1 142 ? -19.087 -36.810 11.322 1.00 58.54 ? 115 VAL A CG2 1 ATOM 4343 N N . ALA B 1 143 ? -16.233 -38.124 9.072 1.00 62.13 ? 116 ALA A N 1 ATOM 4344 C CA . ALA B 1 143 ? -15.073 -37.233 8.904 1.00 68.98 ? 116 ALA A CA 1 ATOM 4345 C C . ALA B 1 143 ? -15.041 -36.628 7.524 1.00 74.42 ? 116 ALA A C 1 ATOM 4346 O O . ALA B 1 143 ? -14.845 -35.424 7.383 1.00 69.35 ? 116 ALA A O 1 ATOM 4347 C CB . ALA B 1 143 ? -13.765 -37.969 9.175 1.00 71.66 ? 116 ALA A CB 1 ATOM 4348 N N . GLN B 1 144 ? -15.251 -37.464 6.506 1.00 81.64 ? 117 GLN A N 1 ATOM 4349 C CA . GLN B 1 144 ? -15.302 -36.961 5.143 1.00 90.90 ? 117 GLN A CA 1 ATOM 4350 C C . GLN B 1 144 ? -16.403 -35.891 5.012 1.00 87.46 ? 117 GLN A C 1 ATOM 4351 O O . GLN B 1 144 ? -16.114 -34.718 4.779 1.00 96.33 ? 117 GLN A O 1 ATOM 4352 C CB . GLN B 1 144 ? -15.491 -38.101 4.134 1.00 96.95 ? 117 GLN A CB 1 ATOM 4353 C CG . GLN B 1 144 ? -14.749 -37.856 2.825 1.00 104.86 ? 117 GLN A CG 1 ATOM 4354 C CD . GLN B 1 144 ? -15.039 -36.484 2.231 1.00 101.21 ? 117 GLN A CD 1 ATOM 4355 O OE1 . GLN B 1 144 ? -16.184 -36.183 1.891 1.00 111.37 ? 117 GLN A OE1 1 ATOM 4356 N NE2 . GLN B 1 144 ? -14.007 -35.645 2.108 1.00 92.32 ? 117 GLN A NE2 1 ATOM 4357 N N . ASN B 1 145 ? -17.646 -36.312 5.217 1.00 88.02 ? 118 ASN A N 1 ATOM 4358 C CA . ASN B 1 145 ? -18.838 -35.446 5.156 1.00 86.20 ? 118 ASN A CA 1 ATOM 4359 C C . ASN B 1 145 ? -18.692 -34.112 5.851 1.00 87.52 ? 118 ASN A C 1 ATOM 4360 O O . ASN B 1 145 ? -19.149 -33.097 5.338 1.00 99.54 ? 118 ASN A O 1 ATOM 4361 C CB . ASN B 1 145 ? -20.042 -36.137 5.812 1.00 84.57 ? 118 ASN A CB 1 ATOM 4362 C CG . ASN B 1 145 ? -20.353 -37.488 5.206 1.00 82.23 ? 118 ASN A CG 1 ATOM 4363 O OD1 . ASN B 1 145 ? -21.323 -37.629 4.450 1.00 69.20 ? 118 ASN A OD1 1 ATOM 4364 N ND2 . ASN B 1 145 ? -19.526 -38.493 5.528 1.00 82.29 ? 118 ASN A ND2 1 ATOM 4365 N N . LYS B 1 146 ? -18.104 -34.143 7.046 1.00 97.09 ? 119 LYS A N 1 ATOM 4366 C CA . LYS B 1 146 ? -17.913 -32.954 7.904 1.00 97.72 ? 119 LYS A CA 1 ATOM 4367 C C . LYS B 1 146 ? -16.993 -31.909 7.271 1.00 99.78 ? 119 LYS A C 1 ATOM 4368 O O . LYS B 1 146 ? -17.310 -30.715 7.282 1.00 88.02 ? 119 LYS A O 1 ATOM 4369 C CB . LYS B 1 146 ? -17.333 -33.384 9.259 1.00 93.20 ? 119 LYS A CB 1 ATOM 4370 C CG . LYS B 1 146 ? -17.171 -32.256 10.266 1.00 88.83 ? 119 LYS A CG 1 ATOM 4371 C CD . LYS B 1 146 ? -15.987 -32.503 11.191 1.00 87.15 ? 119 LYS A CD 1 ATOM 4372 C CE . LYS B 1 146 ? -15.143 -31.246 11.370 1.00 92.74 ? 119 LYS A CE 1 ATOM 4373 N NZ . LYS B 1 146 ? -15.391 -30.506 12.642 1.00 99.74 ? 119 LYS A NZ 1 ATOM 4374 N N . ILE B 1 147 ? -15.864 -32.381 6.725 1.00 104.92 ? 120 ILE A N 1 ATOM 4375 C CA . ILE B 1 147 ? -14.892 -31.536 6.028 1.00 112.45 ? 120 ILE A CA 1 ATOM 4376 C C . ILE B 1 147 ? -15.540 -30.655 4.929 1.00 120.62 ? 120 ILE A C 1 ATOM 4377 O O . ILE B 1 147 ? -15.087 -29.533 4.696 1.00 140.71 ? 120 ILE A O 1 ATOM 4378 C CB . ILE B 1 147 ? -13.716 -32.375 5.458 1.00 101.52 ? 120 ILE A CB 1 ATOM 4379 N N . ASP B 1 148 ? -16.601 -31.137 4.278 1.00 116.39 ? 121 ASP A N 1 ATOM 4380 C CA . ASP B 1 148 ? -17.321 -30.342 3.264 1.00 118.69 ? 121 ASP A CA 1 ATOM 4381 C C . ASP B 1 148 ? -17.906 -29.041 3.846 1.00 110.74 ? 121 ASP A C 1 ATOM 4382 O O . ASP B 1 148 ? -18.817 -29.063 4.674 1.00 107.50 ? 121 ASP A O 1 ATOM 4383 C CB . ASP B 1 148 ? -18.439 -31.172 2.590 1.00 119.08 ? 121 ASP A CB 1 ATOM 4384 C CG . ASP B 1 148 ? -17.901 -32.339 1.726 1.00 110.49 ? 121 ASP A CG 1 ATOM 4385 O OD1 . ASP B 1 148 ? -16.668 -32.568 1.685 1.00 93.90 ? 121 ASP A OD1 1 ATOM 4386 O OD2 . ASP B 1 148 ? -18.729 -33.032 1.089 1.00 99.37 ? 121 ASP A OD2 1 ATOM 4387 N N . SER B 1 164 ? -14.950 -43.310 4.147 1.00 79.73 ? 137 SER A N 1 ATOM 4388 C CA . SER B 1 164 ? -16.307 -42.797 3.980 1.00 85.44 ? 137 SER A CA 1 ATOM 4389 C C . SER B 1 164 ? -17.408 -43.825 4.335 1.00 94.48 ? 137 SER A C 1 ATOM 4390 O O . SER B 1 164 ? -17.430 -44.928 3.784 1.00 117.52 ? 137 SER A O 1 ATOM 4391 C CB . SER B 1 164 ? -16.500 -42.322 2.552 1.00 80.33 ? 137 SER A CB 1 ATOM 4392 O OG . SER B 1 164 ? -17.858 -42.022 2.319 1.00 75.03 ? 137 SER A OG 1 ATOM 4393 N N . THR B 1 165 ? -18.344 -43.427 5.208 1.00 88.61 ? 138 THR A N 1 ATOM 4394 C CA . THR B 1 165 ? -19.277 -44.350 5.895 1.00 79.58 ? 138 THR A CA 1 ATOM 4395 C C . THR B 1 165 ? -20.732 -44.234 5.401 1.00 67.75 ? 138 THR A C 1 ATOM 4396 O O . THR B 1 165 ? -21.327 -43.161 5.409 1.00 66.86 ? 138 THR A O 1 ATOM 4397 C CB . THR B 1 165 ? -19.223 -44.095 7.422 1.00 80.14 ? 138 THR A CB 1 ATOM 4398 O OG1 . THR B 1 165 ? -17.912 -44.405 7.905 1.00 82.52 ? 138 THR A OG1 1 ATOM 4399 C CG2 . THR B 1 165 ? -20.210 -44.952 8.166 1.00 84.42 ? 138 THR A CG2 1 ATOM 4400 N N . ILE B 1 166 ? -21.319 -45.353 5.007 1.00 60.74 ? 139 ILE A N 1 ATOM 4401 C CA . ILE B 1 166 ? -22.625 -45.335 4.343 1.00 62.05 ? 139 ILE A CA 1 ATOM 4402 C C . ILE B 1 166 ? -23.810 -45.580 5.263 1.00 60.47 ? 139 ILE A C 1 ATOM 4403 O O . ILE B 1 166 ? -24.960 -45.286 4.904 1.00 61.83 ? 139 ILE A O 1 ATOM 4404 C CB . ILE B 1 166 ? -22.671 -46.376 3.197 1.00 63.77 ? 139 ILE A CB 1 ATOM 4405 C CG1 . ILE B 1 166 ? -23.344 -45.781 1.982 1.00 68.91 ? 139 ILE A CG1 1 ATOM 4406 C CG2 . ILE B 1 166 ? -23.406 -47.635 3.597 1.00 67.63 ? 139 ILE A CG2 1 ATOM 4407 C CD1 . ILE B 1 166 ? -22.583 -44.584 1.453 1.00 74.45 ? 139 ILE A CD1 1 ATOM 4408 N N . ALA B 1 167 ? -23.539 -46.151 6.430 1.00 55.38 ? 140 ALA A N 1 ATOM 4409 C CA . ALA B 1 167 ? -24.584 -46.528 7.365 1.00 52.87 ? 140 ALA A CA 1 ATOM 4410 C C . ALA B 1 167 ? -23.906 -47.001 8.628 1.00 54.10 ? 140 ALA A C 1 ATOM 4411 O O . ALA B 1 167 ? -22.710 -47.430 8.579 1.00 48.95 ? 140 ALA A O 1 ATOM 4412 C CB . ALA B 1 167 ? -25.486 -47.632 6.799 1.00 50.83 ? 140 ALA A CB 1 ATOM 4413 N N . VAL B 1 168 ? -24.646 -46.902 9.749 1.00 47.78 ? 141 VAL A N 1 ATOM 4414 C CA . VAL B 1 168 ? -24.127 -47.360 11.039 1.00 48.13 ? 141 VAL A CA 1 ATOM 4415 C C . VAL B 1 168 ? -25.090 -48.317 11.731 1.00 52.52 ? 141 VAL A C 1 ATOM 4416 O O . VAL B 1 168 ? -26.324 -48.198 11.674 1.00 53.27 ? 141 VAL A O 1 ATOM 4417 C CB . VAL B 1 168 ? -23.740 -46.194 11.985 1.00 48.20 ? 141 VAL A CB 1 ATOM 4418 C CG1 . VAL B 1 168 ? -23.043 -46.701 13.253 1.00 47.22 ? 141 VAL A CG1 1 ATOM 4419 C CG2 . VAL B 1 168 ? -22.812 -45.195 11.281 1.00 53.49 ? 141 VAL A CG2 1 ATOM 4420 N N . VAL B 1 169 ? -24.488 -49.306 12.357 1.00 51.46 ? 142 VAL A N 1 ATOM 4421 C CA . VAL B 1 169 ? -25.205 -50.209 13.190 1.00 55.29 ? 142 VAL A CA 1 ATOM 4422 C C . VAL B 1 169 ? -24.936 -49.873 14.647 1.00 53.85 ? 142 VAL A C 1 ATOM 4423 O O . VAL B 1 169 ? -23.822 -50.018 15.128 1.00 59.73 ? 142 VAL A O 1 ATOM 4424 C CB . VAL B 1 169 ? -24.773 -51.639 12.891 1.00 58.38 ? 142 VAL A CB 1 ATOM 4425 C CG1 . VAL B 1 169 ? -25.355 -52.600 13.918 1.00 57.27 ? 142 VAL A CG1 1 ATOM 4426 C CG2 . VAL B 1 169 ? -25.210 -52.000 11.473 1.00 61.18 ? 142 VAL A CG2 1 ATOM 4427 N N . GLY B 1 170 ? -25.972 -49.427 15.342 1.00 56.71 ? 143 GLY A N 1 ATOM 4428 C CA . GLY B 1 170 ? -25.932 -49.176 16.792 1.00 51.76 ? 143 GLY A CA 1 ATOM 4429 C C . GLY B 1 170 ? -26.619 -47.862 17.124 1.00 45.53 ? 143 GLY A C 1 ATOM 4430 O O . GLY B 1 170 ? -27.422 -47.368 16.361 1.00 40.82 ? 143 GLY A O 1 ATOM 4431 N N . ALA B 1 171 ? -26.345 -47.304 18.283 1.00 44.38 ? 144 ALA A N 1 ATOM 4432 C CA . ALA B 1 171 ? -25.637 -47.978 19.355 1.00 47.52 ? 144 ALA A CA 1 ATOM 4433 C C . ALA B 1 171 ? -26.590 -48.899 20.198 1.00 49.92 ? 144 ALA A C 1 ATOM 4434 O O . ALA B 1 171 ? -27.679 -49.286 19.738 1.00 48.62 ? 144 ALA A O 1 ATOM 4435 C CB . ALA B 1 171 ? -25.023 -46.902 20.219 1.00 46.48 ? 144 ALA A CB 1 ATOM 4436 N N . THR B 1 172 ? -26.183 -49.229 21.428 1.00 49.25 ? 145 THR A N 1 ATOM 4437 C CA . THR B 1 172 ? -27.020 -50.003 22.361 1.00 54.24 ? 145 THR A CA 1 ATOM 4438 C C . THR B 1 172 ? -27.978 -49.143 23.212 1.00 53.06 ? 145 THR A C 1 ATOM 4439 O O . THR B 1 172 ? -29.202 -49.201 23.041 1.00 51.97 ? 145 THR A O 1 ATOM 4440 C CB . THR B 1 172 ? -26.138 -50.867 23.278 1.00 52.95 ? 145 THR A CB 1 ATOM 4441 O OG1 . THR B 1 172 ? -25.477 -51.835 22.461 1.00 60.94 ? 145 THR A OG1 1 ATOM 4442 C CG2 . THR B 1 172 ? -26.953 -51.603 24.303 1.00 52.58 ? 145 THR A CG2 1 ATOM 4443 N N . GLY B 1 173 ? -27.412 -48.351 24.117 1.00 53.20 ? 146 GLY A N 1 ATOM 4444 C CA . GLY B 1 173 ? -28.194 -47.527 25.032 1.00 47.76 ? 146 GLY A CA 1 ATOM 4445 C C . GLY B 1 173 ? -28.864 -46.376 24.306 1.00 48.95 ? 146 GLY A C 1 ATOM 4446 O O . GLY B 1 173 ? -28.212 -45.677 23.491 1.00 47.02 ? 146 GLY A O 1 ATOM 4447 N N . SER B 1 174 ? -30.160 -46.190 24.582 1.00 41.80 ? 147 SER A N 1 ATOM 4448 C CA . SER B 1 174 ? -30.920 -45.116 23.969 1.00 45.68 ? 147 SER A CA 1 ATOM 4449 C C . SER B 1 174 ? -30.252 -43.724 24.095 1.00 42.17 ? 147 SER A C 1 ATOM 4450 O O . SER B 1 174 ? -30.266 -42.953 23.154 1.00 41.94 ? 147 SER A O 1 ATOM 4451 C CB . SER B 1 174 ? -32.342 -45.066 24.535 1.00 47.95 ? 147 SER A CB 1 ATOM 4452 O OG . SER B 1 174 ? -33.162 -45.967 23.837 1.00 49.34 ? 147 SER A OG 1 ATOM 4453 N N . GLY B 1 175 ? -29.665 -43.432 25.250 1.00 42.30 ? 148 GLY A N 1 ATOM 4454 C CA . GLY B 1 175 ? -28.919 -42.196 25.493 1.00 41.27 ? 148 GLY A CA 1 ATOM 4455 C C . GLY B 1 175 ? -27.727 -41.970 24.570 1.00 46.54 ? 148 GLY A C 1 ATOM 4456 O O . GLY B 1 175 ? -27.391 -40.826 24.211 1.00 46.32 ? 148 GLY A O 1 ATOM 4457 N N . VAL B 1 176 ? -27.072 -43.071 24.217 1.00 49.06 ? 149 VAL A N 1 ATOM 4458 C CA . VAL B 1 176 ? -25.953 -43.045 23.321 1.00 46.67 ? 149 VAL A CA 1 ATOM 4459 C C . VAL B 1 176 ? -26.476 -42.893 21.903 1.00 46.86 ? 149 VAL A C 1 ATOM 4460 O O . VAL B 1 176 ? -26.006 -42.043 21.189 1.00 49.40 ? 149 VAL A O 1 ATOM 4461 C CB . VAL B 1 176 ? -25.122 -44.328 23.457 1.00 47.29 ? 149 VAL A CB 1 ATOM 4462 C CG1 . VAL B 1 176 ? -24.044 -44.408 22.373 1.00 46.04 ? 149 VAL A CG1 1 ATOM 4463 C CG2 . VAL B 1 176 ? -24.516 -44.401 24.851 1.00 46.35 ? 149 VAL A CG2 1 ATOM 4464 N N . SER B 1 177 ? -27.438 -43.710 21.493 1.00 47.66 ? 150 SER A N 1 ATOM 4465 C CA . SER B 1 177 ? -27.979 -43.609 20.124 1.00 49.17 ? 150 SER A CA 1 ATOM 4466 C C . SER B 1 177 ? -28.586 -42.232 19.858 1.00 46.18 ? 150 SER A C 1 ATOM 4467 O O . SER B 1 177 ? -28.507 -41.719 18.749 1.00 51.30 ? 150 SER A O 1 ATOM 4468 C CB . SER B 1 177 ? -29.040 -44.685 19.837 1.00 48.51 ? 150 SER A CB 1 ATOM 4469 O OG . SER B 1 177 ? -28.493 -45.975 19.763 1.00 43.97 ? 150 SER A OG 1 ATOM 4470 N N . THR B 1 178 ? -29.200 -41.645 20.863 1.00 41.64 ? 151 THR A N 1 ATOM 4471 C CA . THR B 1 178 ? -29.638 -40.265 20.773 1.00 43.66 ? 151 THR A CA 1 ATOM 4472 C C . THR B 1 178 ? -28.508 -39.317 20.382 1.00 41.68 ? 151 THR A C 1 ATOM 4473 O O . THR B 1 178 ? -28.611 -38.584 19.453 1.00 40.09 ? 151 THR A O 1 ATOM 4474 C CB . THR B 1 178 ? -30.161 -39.815 22.134 1.00 49.29 ? 151 THR A CB 1 ATOM 4475 O OG1 . THR B 1 178 ? -31.452 -40.397 22.340 1.00 49.61 ? 151 THR A OG1 1 ATOM 4476 C CG2 . THR B 1 178 ? -30.289 -38.298 22.186 1.00 61.33 ? 151 THR A CG2 1 ATOM 4477 N N . ALA B 1 179 ? -27.420 -39.326 21.122 1.00 42.37 ? 152 ALA A N 1 ATOM 4478 C CA . ALA B 1 179 ? -26.341 -38.419 20.854 1.00 43.74 ? 152 ALA A CA 1 ATOM 4479 C C . ALA B 1 179 ? -25.815 -38.633 19.466 1.00 46.14 ? 152 ALA A C 1 ATOM 4480 O O . ALA B 1 179 ? -25.611 -37.685 18.720 1.00 48.74 ? 152 ALA A O 1 ATOM 4481 C CB . ALA B 1 179 ? -25.230 -38.628 21.850 1.00 45.44 ? 152 ALA A CB 1 ATOM 4482 N N . VAL B 1 180 ? -25.599 -39.889 19.126 1.00 46.20 ? 153 VAL A N 1 ATOM 4483 C CA . VAL B 1 180 ? -25.057 -40.237 17.831 1.00 50.69 ? 153 VAL A CA 1 ATOM 4484 C C . VAL B 1 180 ? -26.002 -39.773 16.724 1.00 54.54 ? 153 VAL A C 1 ATOM 4485 O O . VAL B 1 180 ? -25.576 -39.152 15.740 1.00 50.90 ? 153 VAL A O 1 ATOM 4486 C CB . VAL B 1 180 ? -24.891 -41.752 17.724 1.00 50.43 ? 153 VAL A CB 1 ATOM 4487 C CG1 . VAL B 1 180 ? -24.722 -42.187 16.273 1.00 51.05 ? 153 VAL A CG1 1 ATOM 4488 C CG2 . VAL B 1 180 ? -23.721 -42.188 18.595 1.00 53.40 ? 153 VAL A CG2 1 ATOM 4489 N N . ALA B 1 181 ? -27.283 -40.075 16.916 1.00 49.70 ? 154 ALA A N 1 ATOM 4490 C CA . ALA B 1 181 ? -28.291 -39.827 15.919 1.00 47.43 ? 154 ALA A CA 1 ATOM 4491 C C . ALA B 1 181 ? -28.381 -38.359 15.598 1.00 48.99 ? 154 ALA A C 1 ATOM 4492 O O . ALA B 1 181 ? -28.694 -38.023 14.484 1.00 50.20 ? 154 ALA A O 1 ATOM 4493 C CB . ALA B 1 181 ? -29.643 -40.337 16.400 1.00 46.01 ? 154 ALA A CB 1 ATOM 4494 N N . ASN B 1 182 ? -28.145 -37.478 16.568 1.00 51.48 ? 155 ASN A N 1 ATOM 4495 C CA . ASN B 1 182 ? -28.134 -36.049 16.272 1.00 53.82 ? 155 ASN A CA 1 ATOM 4496 C C . ASN B 1 182 ? -27.061 -35.771 15.219 1.00 50.08 ? 155 ASN A C 1 ATOM 4497 O O . ASN B 1 182 ? -27.271 -35.033 14.265 1.00 49.49 ? 155 ASN A O 1 ATOM 4498 C CB . ASN B 1 182 ? -27.867 -35.201 17.531 1.00 55.84 ? 155 ASN A CB 1 ATOM 4499 C CG . ASN B 1 182 ? -29.058 -35.140 18.475 1.00 53.46 ? 155 ASN A CG 1 ATOM 4500 O OD1 . ASN B 1 182 ? -30.209 -35.153 18.043 1.00 56.59 ? 155 ASN A OD1 1 ATOM 4501 N ND2 . ASN B 1 182 ? -28.778 -35.068 19.778 1.00 52.33 ? 155 ASN A ND2 1 ATOM 4502 N N . LEU B 1 183 ? -25.917 -36.405 15.383 1.00 52.39 ? 156 LEU A N 1 ATOM 4503 C CA . LEU B 1 183 ? -24.788 -36.182 14.479 1.00 53.16 ? 156 LEU A CA 1 ATOM 4504 C C . LEU B 1 183 ? -24.951 -36.825 13.090 1.00 49.41 ? 156 LEU A C 1 ATOM 4505 O O . LEU B 1 183 ? -24.743 -36.174 12.106 1.00 44.55 ? 156 LEU A O 1 ATOM 4506 C CB . LEU B 1 183 ? -23.491 -36.679 15.122 1.00 52.71 ? 156 LEU A CB 1 ATOM 4507 C CG . LEU B 1 183 ? -22.370 -35.648 15.130 1.00 55.65 ? 156 LEU A CG 1 ATOM 4508 C CD1 . LEU B 1 183 ? -21.096 -36.267 15.694 1.00 56.79 ? 156 LEU A CD1 1 ATOM 4509 C CD2 . LEU B 1 183 ? -22.118 -35.059 13.749 1.00 55.06 ? 156 LEU A CD2 1 ATOM 4510 N N . LEU B 1 184 ? -25.326 -38.097 13.024 1.00 51.69 ? 157 LEU A N 1 ATOM 4511 C CA . LEU B 1 184 ? -25.472 -38.781 11.752 1.00 52.27 ? 157 LEU A CA 1 ATOM 4512 C C . LEU B 1 184 ? -26.560 -38.134 10.927 1.00 55.06 ? 157 LEU A C 1 ATOM 4513 O O . LEU B 1 184 ? -26.430 -38.005 9.686 1.00 59.71 ? 157 LEU A O 1 ATOM 4514 C CB . LEU B 1 184 ? -25.793 -40.248 11.960 1.00 52.37 ? 157 LEU A CB 1 ATOM 4515 C CG . LEU B 1 184 ? -24.650 -41.045 12.578 1.00 53.88 ? 157 LEU A CG 1 ATOM 4516 C CD1 . LEU B 1 184 ? -25.087 -42.486 12.744 1.00 54.91 ? 157 LEU A CD1 1 ATOM 4517 C CD2 . LEU B 1 184 ? -23.393 -40.968 11.733 1.00 55.85 ? 157 LEU A CD2 1 ATOM 4518 N N . GLY B 1 185 ? -27.619 -37.718 11.616 1.00 49.57 ? 158 GLY A N 1 ATOM 4519 C CA . GLY B 1 185 ? -28.758 -37.014 10.992 1.00 50.63 ? 158 GLY A CA 1 ATOM 4520 C C . GLY B 1 185 ? -28.412 -35.777 10.161 1.00 53.36 ? 158 GLY A C 1 ATOM 4521 O O . GLY B 1 185 ? -29.052 -35.505 9.146 1.00 52.50 ? 158 GLY A O 1 ATOM 4522 N N . LEU B 1 186 ? -27.415 -35.014 10.583 1.00 52.33 ? 159 LEU A N 1 ATOM 4523 C CA . LEU B 1 186 ? -26.987 -33.863 9.788 1.00 60.47 ? 159 LEU A CA 1 ATOM 4524 C C . LEU B 1 186 ? -26.624 -34.270 8.389 1.00 60.37 ? 159 LEU A C 1 ATOM 4525 O O . LEU B 1 186 ? -26.957 -33.575 7.444 1.00 59.35 ? 159 LEU A O 1 ATOM 4526 C CB . LEU B 1 186 ? -25.725 -33.233 10.370 1.00 62.60 ? 159 LEU A CB 1 ATOM 4527 C CG . LEU B 1 186 ? -25.913 -32.416 11.617 1.00 62.75 ? 159 LEU A CG 1 ATOM 4528 C CD1 . LEU B 1 186 ? -24.546 -32.103 12.207 1.00 61.92 ? 159 LEU A CD1 1 ATOM 4529 C CD2 . LEU B 1 186 ? -26.692 -31.167 11.226 1.00 65.22 ? 159 LEU A CD2 1 ATOM 4530 N N . PHE B 1 187 ? -25.908 -35.389 8.285 1.00 62.03 ? 160 PHE A N 1 ATOM 4531 C CA . PHE B 1 187 ? -25.353 -35.863 7.026 1.00 59.25 ? 160 PHE A CA 1 ATOM 4532 C C . PHE B 1 187 ? -26.213 -36.938 6.411 1.00 58.51 ? 160 PHE A C 1 ATOM 4533 O O . PHE B 1 187 ? -25.782 -37.640 5.514 1.00 66.30 ? 160 PHE A O 1 ATOM 4534 C CB . PHE B 1 187 ? -23.948 -36.364 7.298 1.00 57.95 ? 160 PHE A CB 1 ATOM 4535 C CG . PHE B 1 187 ? -23.108 -35.354 8.016 1.00 65.95 ? 160 PHE A CG 1 ATOM 4536 C CD1 . PHE B 1 187 ? -22.926 -34.087 7.479 1.00 72.35 ? 160 PHE A CD1 1 ATOM 4537 C CD2 . PHE B 1 187 ? -22.541 -35.638 9.242 1.00 69.40 ? 160 PHE A CD2 1 ATOM 4538 C CE1 . PHE B 1 187 ? -22.180 -33.130 8.146 1.00 74.70 ? 160 PHE A CE1 1 ATOM 4539 C CE2 . PHE B 1 187 ? -21.782 -34.689 9.912 1.00 72.95 ? 160 PHE A CE2 1 ATOM 4540 C CZ . PHE B 1 187 ? -21.601 -33.430 9.366 1.00 71.51 ? 160 PHE A CZ 1 ATOM 4541 N N . TYR B 1 188 ? -27.429 -37.078 6.924 1.00 56.62 ? 161 TYR A N 1 ATOM 4542 C CA . TYR B 1 188 ? -28.372 -38.075 6.461 1.00 55.34 ? 161 TYR A CA 1 ATOM 4543 C C . TYR B 1 188 ? -27.756 -39.456 6.296 1.00 53.96 ? 161 TYR A C 1 ATOM 4544 O O . TYR B 1 188 ? -28.141 -40.225 5.410 1.00 44.38 ? 161 TYR A O 1 ATOM 4545 C CB . TYR B 1 188 ? -29.007 -37.622 5.162 1.00 52.25 ? 161 TYR A CB 1 ATOM 4546 C CG . TYR B 1 188 ? -29.917 -36.456 5.344 1.00 55.03 ? 161 TYR A CG 1 ATOM 4547 C CD1 . TYR B 1 188 ? -29.425 -35.140 5.282 1.00 59.62 ? 161 TYR A CD1 1 ATOM 4548 C CD2 . TYR B 1 188 ? -31.266 -36.648 5.590 1.00 51.06 ? 161 TYR A CD2 1 ATOM 4549 C CE1 . TYR B 1 188 ? -30.275 -34.054 5.444 1.00 58.10 ? 161 TYR A CE1 1 ATOM 4550 C CE2 . TYR B 1 188 ? -32.120 -35.574 5.761 1.00 53.92 ? 161 TYR A CE2 1 ATOM 4551 C CZ . TYR B 1 188 ? -31.630 -34.284 5.672 1.00 58.34 ? 161 TYR A CZ 1 ATOM 4552 O OH . TYR B 1 188 ? -32.501 -33.226 5.803 1.00 63.23 ? 161 TYR A OH 1 ATOM 4553 N N . ILE B 1 189 ? -26.837 -39.783 7.193 1.00 55.90 ? 162 ILE A N 1 ATOM 4554 C CA . ILE B 1 189 ? -26.294 -41.122 7.234 1.00 56.73 ? 162 ILE A CA 1 ATOM 4555 C C . ILE B 1 189 ? -27.259 -42.006 8.027 1.00 57.69 ? 162 ILE A C 1 ATOM 4556 O O . ILE B 1 189 ? -27.531 -41.733 9.182 1.00 52.23 ? 162 ILE A O 1 ATOM 4557 C CB . ILE B 1 189 ? -24.919 -41.114 7.878 1.00 56.92 ? 162 ILE A CB 1 ATOM 4558 C CG1 . ILE B 1 189 ? -24.032 -40.135 7.108 1.00 57.59 ? 162 ILE A CG1 1 ATOM 4559 C CG2 . ILE B 1 189 ? -24.346 -42.518 7.882 1.00 56.99 ? 162 ILE A CG2 1 ATOM 4560 C CD1 . ILE B 1 189 ? -22.598 -40.107 7.565 1.00 57.44 ? 162 ILE A CD1 1 ATOM 4561 N N . PRO B 1 190 ? -27.802 -43.056 7.394 1.00 63.84 ? 163 PRO A N 1 ATOM 4562 C CA . PRO B 1 190 ? -28.724 -43.934 8.123 1.00 60.21 ? 163 PRO A CA 1 ATOM 4563 C C . PRO B 1 190 ? -28.023 -44.628 9.275 1.00 57.39 ? 163 PRO A C 1 ATOM 4564 O O . PRO B 1 190 ? -26.845 -44.993 9.155 1.00 50.01 ? 163 PRO A O 1 ATOM 4565 C CB . PRO B 1 190 ? -29.162 -44.963 7.072 1.00 58.73 ? 163 PRO A CB 1 ATOM 4566 C CG . PRO B 1 190 ? -28.080 -44.941 6.058 1.00 62.91 ? 163 PRO A CG 1 ATOM 4567 C CD . PRO B 1 190 ? -27.534 -43.549 6.031 1.00 64.19 ? 163 PRO A CD 1 ATOM 4568 N N . GLN B 1 191 ? -28.746 -44.772 10.385 1.00 53.45 ? 164 GLN A N 1 ATOM 4569 C CA . GLN B 1 191 ? -28.267 -45.472 11.547 1.00 47.29 ? 164 GLN A CA 1 ATOM 4570 C C . GLN B 1 191 ? -29.325 -46.484 11.867 1.00 48.77 ? 164 GLN A C 1 ATOM 4571 O O . GLN B 1 191 ? -30.493 -46.138 11.889 1.00 53.13 ? 164 GLN A O 1 ATOM 4572 C CB . GLN B 1 191 ? -28.139 -44.493 12.685 1.00 49.83 ? 164 GLN A CB 1 ATOM 4573 C CG . GLN B 1 191 ? -27.797 -45.101 14.047 1.00 51.12 ? 164 GLN A CG 1 ATOM 4574 C CD . GLN B 1 191 ? -27.772 -44.050 15.138 1.00 51.75 ? 164 GLN A CD 1 ATOM 4575 O OE1 . GLN B 1 191 ? -27.852 -42.834 14.864 1.00 52.96 ? 164 GLN A OE1 1 ATOM 4576 N NE2 . GLN B 1 191 ? -27.683 -44.502 16.381 1.00 54.07 ? 164 GLN A NE2 1 ATOM 4577 N N . VAL B 1 192 ? -28.932 -47.728 12.102 1.00 50.77 ? 165 VAL A N 1 ATOM 4578 C CA . VAL B 1 192 ? -29.883 -48.781 12.460 1.00 52.53 ? 165 VAL A CA 1 ATOM 4579 C C . VAL B 1 192 ? -29.522 -49.377 13.808 1.00 53.88 ? 165 VAL A C 1 ATOM 4580 O O . VAL B 1 192 ? -28.505 -50.042 13.924 1.00 49.05 ? 165 VAL A O 1 ATOM 4581 C CB . VAL B 1 192 ? -29.895 -49.909 11.421 1.00 54.04 ? 165 VAL A CB 1 ATOM 4582 C CG1 . VAL B 1 192 ? -30.838 -51.017 11.841 1.00 56.88 ? 165 VAL A CG1 1 ATOM 4583 C CG2 . VAL B 1 192 ? -30.298 -49.356 10.064 1.00 57.82 ? 165 VAL A CG2 1 ATOM 4584 N N . SER B 1 193 ? -30.349 -49.161 14.831 1.00 55.76 ? 166 SER A N 1 ATOM 4585 C CA . SER B 1 193 ? -30.025 -49.727 16.124 1.00 56.45 ? 166 SER A CA 1 ATOM 4586 C C . SER B 1 193 ? -30.626 -51.094 16.358 1.00 54.76 ? 166 SER A C 1 ATOM 4587 O O . SER B 1 193 ? -31.815 -51.325 16.150 1.00 56.39 ? 166 SER A O 1 ATOM 4588 C CB . SER B 1 193 ? -30.435 -48.823 17.268 1.00 58.11 ? 166 SER A CB 1 ATOM 4589 O OG . SER B 1 193 ? -29.911 -49.351 18.486 1.00 53.44 ? 166 SER A OG 1 ATOM 4590 N N . TYR B 1 194 ? -29.765 -51.984 16.831 1.00 52.48 ? 167 TYR A N 1 ATOM 4591 C CA . TYR B 1 194 ? -30.140 -53.319 17.273 1.00 50.96 ? 167 TYR A CA 1 ATOM 4592 C C . TYR B 1 194 ? -30.763 -53.356 18.690 1.00 53.63 ? 167 TYR A C 1 ATOM 4593 O O . TYR B 1 194 ? -31.342 -54.360 19.051 1.00 64.88 ? 167 TYR A O 1 ATOM 4594 C CB . TYR B 1 194 ? -28.892 -54.209 17.231 1.00 48.58 ? 167 TYR A CB 1 ATOM 4595 C CG . TYR B 1 194 ? -27.667 -53.621 17.914 1.00 44.70 ? 167 TYR A CG 1 ATOM 4596 C CD1 . TYR B 1 194 ? -27.444 -53.798 19.271 1.00 43.79 ? 167 TYR A CD1 1 ATOM 4597 C CD2 . TYR B 1 194 ? -26.719 -52.904 17.193 1.00 45.17 ? 167 TYR A CD2 1 ATOM 4598 C CE1 . TYR B 1 194 ? -26.318 -53.256 19.902 1.00 44.25 ? 167 TYR A CE1 1 ATOM 4599 C CE2 . TYR B 1 194 ? -25.596 -52.361 17.815 1.00 42.48 ? 167 TYR A CE2 1 ATOM 4600 C CZ . TYR B 1 194 ? -25.397 -52.546 19.170 1.00 43.41 ? 167 TYR A CZ 1 ATOM 4601 O OH . TYR B 1 194 ? -24.288 -52.030 19.811 1.00 45.66 ? 167 TYR A OH 1 ATOM 4602 N N . ALA B 1 195 ? -30.649 -52.287 19.487 1.00 52.04 ? 168 ALA A N 1 ATOM 4603 C CA . ALA B 1 195 ? -31.077 -52.325 20.901 1.00 51.34 ? 168 ALA A CA 1 ATOM 4604 C C . ALA B 1 195 ? -31.610 -51.024 21.565 1.00 49.52 ? 168 ALA A C 1 ATOM 4605 O O . ALA B 1 195 ? -32.045 -51.057 22.710 1.00 47.14 ? 168 ALA A O 1 ATOM 4606 C CB . ALA B 1 195 ? -29.938 -52.883 21.751 1.00 52.24 ? 168 ALA A CB 1 ATOM 4607 N N . SER B 1 196 ? -31.562 -49.880 20.904 1.00 46.03 ? 169 SER A N 1 ATOM 4608 C CA . SER B 1 196 ? -32.166 -48.689 21.495 1.00 43.26 ? 169 SER A CA 1 ATOM 4609 C C . SER B 1 196 ? -33.706 -48.589 21.291 1.00 41.21 ? 169 SER A C 1 ATOM 4610 O O . SER B 1 196 ? -34.182 -48.443 20.184 1.00 38.41 ? 169 SER A O 1 ATOM 4611 C CB . SER B 1 196 ? -31.454 -47.455 20.984 1.00 42.09 ? 169 SER A CB 1 ATOM 4612 O OG . SER B 1 196 ? -30.133 -47.494 21.474 1.00 45.06 ? 169 SER A OG 1 ATOM 4613 N N . SER B 1 197 ? -34.480 -48.626 22.371 1.00 39.92 ? 170 SER A N 1 ATOM 4614 C CA . SER B 1 197 ? -35.941 -48.816 22.267 1.00 40.23 ? 170 SER A CA 1 ATOM 4615 C C . SER B 1 197 ? -36.752 -47.636 22.849 1.00 44.19 ? 170 SER A C 1 ATOM 4616 O O . SER B 1 197 ? -37.972 -47.746 23.071 1.00 41.90 ? 170 SER A O 1 ATOM 4617 C CB . SER B 1 197 ? -36.323 -50.103 22.980 1.00 39.01 ? 170 SER A CB 1 ATOM 4618 O OG . SER B 1 197 ? -35.765 -50.130 24.312 1.00 39.42 ? 170 SER A OG 1 ATOM 4619 N N . SER B 1 198 ? -36.084 -46.502 23.057 1.00 41.74 ? 171 SER A N 1 ATOM 4620 C CA . SER B 1 198 ? -36.752 -45.315 23.533 1.00 41.29 ? 171 SER A CA 1 ATOM 4621 C C . SER B 1 198 ? -37.775 -44.786 22.519 1.00 40.25 ? 171 SER A C 1 ATOM 4622 O O . SER B 1 198 ? -37.523 -44.739 21.332 1.00 41.19 ? 171 SER A O 1 ATOM 4623 C CB . SER B 1 198 ? -35.739 -44.226 23.904 1.00 40.27 ? 171 SER A CB 1 ATOM 4624 O OG . SER B 1 198 ? -36.427 -43.078 24.393 1.00 41.43 ? 171 SER A OG 1 ATOM 4625 N N . ARG B 1 199 ? -38.953 -44.400 22.993 1.00 41.49 ? 172 ARG A N 1 ATOM 4626 C CA . ARG B 1 199 ? -39.915 -43.781 22.094 1.00 39.68 ? 172 ARG A CA 1 ATOM 4627 C C . ARG B 1 199 ? -39.412 -42.429 21.579 1.00 40.05 ? 172 ARG A C 1 ATOM 4628 O O . ARG B 1 199 ? -39.931 -41.929 20.577 1.00 42.18 ? 172 ARG A O 1 ATOM 4629 C CB . ARG B 1 199 ? -41.239 -43.550 22.806 1.00 40.81 ? 172 ARG A CB 1 ATOM 4630 C CG . ARG B 1 199 ? -41.156 -42.405 23.776 1.00 43.55 ? 172 ARG A CG 1 ATOM 4631 C CD . ARG B 1 199 ? -42.462 -41.762 24.041 1.00 49.39 ? 172 ARG A CD 1 ATOM 4632 N NE . ARG B 1 199 ? -42.294 -40.639 24.963 1.00 56.51 ? 172 ARG A NE 1 ATOM 4633 C CZ . ARG B 1 199 ? -42.147 -39.363 24.612 1.00 48.86 ? 172 ARG A CZ 1 ATOM 4634 N NH1 . ARG B 1 199 ? -42.105 -39.009 23.342 1.00 46.66 ? 172 ARG A NH1 1 ATOM 4635 N NH2 . ARG B 1 199 ? -42.045 -38.446 25.559 1.00 48.66 ? 172 ARG A NH2 1 ATOM 4636 N N . LEU B 1 200 ? -38.457 -41.808 22.289 1.00 37.10 ? 173 LEU A N 1 ATOM 4637 C CA . LEU B 1 200 ? -37.922 -40.529 21.872 1.00 38.20 ? 173 LEU A CA 1 ATOM 4638 C C . LEU B 1 200 ? -37.356 -40.687 20.477 1.00 40.17 ? 173 LEU A C 1 ATOM 4639 O O . LEU B 1 200 ? -37.526 -39.795 19.654 1.00 42.05 ? 173 LEU A O 1 ATOM 4640 C CB . LEU B 1 200 ? -36.876 -39.971 22.840 1.00 38.89 ? 173 LEU A CB 1 ATOM 4641 C CG . LEU B 1 200 ? -37.477 -39.714 24.228 1.00 45.89 ? 173 LEU A CG 1 ATOM 4642 C CD1 . LEU B 1 200 ? -36.401 -39.498 25.258 1.00 48.24 ? 173 LEU A CD1 1 ATOM 4643 C CD2 . LEU B 1 200 ? -38.477 -38.550 24.277 1.00 47.85 ? 173 LEU A CD2 1 ATOM 4644 N N . LEU B 1 201 ? -36.783 -41.858 20.193 1.00 42.96 ? 174 LEU A N 1 ATOM 4645 C CA . LEU B 1 201 ? -36.203 -42.132 18.891 1.00 46.25 ? 174 LEU A CA 1 ATOM 4646 C C . LEU B 1 201 ? -37.180 -42.293 17.715 1.00 46.12 ? 174 LEU A C 1 ATOM 4647 O O . LEU B 1 201 ? -36.753 -42.242 16.559 1.00 53.86 ? 174 LEU A O 1 ATOM 4648 C CB . LEU B 1 201 ? -35.276 -43.340 18.978 1.00 47.26 ? 174 LEU A CB 1 ATOM 4649 C CG . LEU B 1 201 ? -33.963 -43.053 19.708 1.00 48.87 ? 174 LEU A CG 1 ATOM 4650 C CD1 . LEU B 1 201 ? -33.320 -44.336 20.217 1.00 50.54 ? 174 LEU A CD1 1 ATOM 4651 C CD2 . LEU B 1 201 ? -32.982 -42.290 18.838 1.00 45.08 ? 174 LEU A CD2 1 ATOM 4652 N N . SER B 1 202 ? -38.460 -42.490 17.979 1.00 45.48 ? 175 SER A N 1 ATOM 4653 C CA . SER B 1 202 ? -39.488 -42.511 16.904 1.00 46.69 ? 175 SER A CA 1 ATOM 4654 C C . SER B 1 202 ? -39.747 -41.135 16.286 1.00 48.24 ? 175 SER A C 1 ATOM 4655 O O . SER B 1 202 ? -40.461 -41.032 15.286 1.00 48.13 ? 175 SER A O 1 ATOM 4656 C CB . SER B 1 202 ? -40.849 -42.989 17.446 1.00 48.64 ? 175 SER A CB 1 ATOM 4657 O OG . SER B 1 202 ? -40.795 -44.298 18.006 1.00 51.41 ? 175 SER A OG 1 ATOM 4658 N N . ASN B 1 203 ? -39.220 -40.078 16.898 1.00 45.67 ? 176 ASN A N 1 ATOM 4659 C CA . ASN B 1 203 ? -39.491 -38.752 16.448 1.00 44.16 ? 176 ASN A CA 1 ATOM 4660 C C . ASN B 1 203 ? -38.586 -38.395 15.252 1.00 49.51 ? 176 ASN A C 1 ATOM 4661 O O . ASN B 1 203 ? -37.405 -38.054 15.410 1.00 48.82 ? 176 ASN A O 1 ATOM 4662 C CB . ASN B 1 203 ? -39.285 -37.798 17.597 1.00 46.44 ? 176 ASN A CB 1 ATOM 4663 C CG . ASN B 1 203 ? -39.481 -36.353 17.193 1.00 54.03 ? 176 ASN A CG 1 ATOM 4664 O OD1 . ASN B 1 203 ? -39.296 -35.442 18.004 1.00 47.20 ? 176 ASN A OD1 1 ATOM 4665 N ND2 . ASN B 1 203 ? -39.822 -36.123 15.920 1.00 56.73 ? 176 ASN A ND2 1 ATOM 4666 N N . LYS B 1 204 ? -39.158 -38.462 14.053 1.00 50.67 ? 177 LYS A N 1 ATOM 4667 C CA . LYS B 1 204 ? -38.379 -38.303 12.839 1.00 47.61 ? 177 LYS A CA 1 ATOM 4668 C C . LYS B 1 204 ? -38.070 -36.865 12.461 1.00 53.92 ? 177 LYS A C 1 ATOM 4669 O O . LYS B 1 204 ? -37.158 -36.655 11.660 1.00 57.09 ? 177 LYS A O 1 ATOM 4670 C CB . LYS B 1 204 ? -39.045 -38.963 11.661 1.00 45.16 ? 177 LYS A CB 1 ATOM 4671 C CG . LYS B 1 204 ? -39.229 -40.461 11.720 1.00 44.92 ? 177 LYS A CG 1 ATOM 4672 C CD . LYS B 1 204 ? -37.961 -41.252 11.926 1.00 46.17 ? 177 LYS A CD 1 ATOM 4673 C CE . LYS B 1 204 ? -37.713 -41.525 13.398 1.00 48.98 ? 177 LYS A CE 1 ATOM 4674 N NZ . LYS B 1 204 ? -36.730 -42.621 13.579 1.00 53.73 ? 177 LYS A NZ 1 ATOM 4675 N N . ASN B 1 205 ? -38.777 -35.878 13.009 1.00 54.02 ? 178 ASN A N 1 ATOM 4676 C CA . ASN B 1 205 ? -38.275 -34.487 12.924 1.00 57.46 ? 178 ASN A CA 1 ATOM 4677 C C . ASN B 1 205 ? -36.903 -34.326 13.576 1.00 54.70 ? 178 ASN A C 1 ATOM 4678 O O . ASN B 1 205 ? -36.007 -33.742 12.985 1.00 50.97 ? 178 ASN A O 1 ATOM 4679 C CB . ASN B 1 205 ? -39.242 -33.480 13.555 1.00 64.35 ? 178 ASN A CB 1 ATOM 4680 C CG . ASN B 1 205 ? -40.631 -33.561 12.950 1.00 68.90 ? 178 ASN A CG 1 ATOM 4681 O OD1 . ASN B 1 205 ? -40.810 -33.251 11.773 1.00 70.35 ? 178 ASN A OD1 1 ATOM 4682 N ND2 . ASN B 1 205 ? -41.622 -34.007 13.743 1.00 70.60 ? 178 ASN A ND2 1 ATOM 4683 N N . GLN B 1 206 ? -36.718 -34.862 14.780 1.00 52.22 ? 179 GLN A N 1 ATOM 4684 C CA . GLN B 1 206 ? -35.412 -34.757 15.408 1.00 52.55 ? 179 GLN A CA 1 ATOM 4685 C C . GLN B 1 206 ? -34.462 -35.797 14.888 1.00 53.32 ? 179 GLN A C 1 ATOM 4686 O O . GLN B 1 206 ? -33.304 -35.484 14.695 1.00 56.57 ? 179 GLN A O 1 ATOM 4687 C CB . GLN B 1 206 ? -35.456 -34.859 16.933 1.00 60.49 ? 179 GLN A CB 1 ATOM 4688 C CG . GLN B 1 206 ? -34.038 -34.840 17.520 1.00 71.64 ? 179 GLN A CG 1 ATOM 4689 C CD . GLN B 1 206 ? -33.805 -33.954 18.752 1.00 81.91 ? 179 GLN A CD 1 ATOM 4690 O OE1 . GLN B 1 206 ? -32.785 -34.102 19.459 1.00 76.26 ? 179 GLN A OE1 1 ATOM 4691 N NE2 . GLN B 1 206 ? -34.714 -33.016 18.998 1.00 91.15 ? 179 GLN A NE2 1 ATOM 4692 N N . PHE B 1 207 ? -34.912 -37.041 14.689 1.00 55.31 ? 180 PHE A N 1 ATOM 4693 C CA . PHE B 1 207 ? -33.985 -38.099 14.261 1.00 50.54 ? 180 PHE A CA 1 ATOM 4694 C C . PHE B 1 207 ? -34.341 -38.597 12.886 1.00 56.38 ? 180 PHE A C 1 ATOM 4695 O O . PHE B 1 207 ? -35.010 -39.627 12.710 1.00 54.02 ? 180 PHE A O 1 ATOM 4696 C CB . PHE B 1 207 ? -33.908 -39.233 15.246 1.00 45.80 ? 180 PHE A CB 1 ATOM 4697 C CG . PHE B 1 207 ? -33.775 -38.785 16.640 1.00 44.79 ? 180 PHE A CG 1 ATOM 4698 C CD1 . PHE B 1 207 ? -32.567 -38.267 17.082 1.00 41.57 ? 180 PHE A CD1 1 ATOM 4699 C CD2 . PHE B 1 207 ? -34.881 -38.859 17.535 1.00 42.60 ? 180 PHE A CD2 1 ATOM 4700 C CE1 . PHE B 1 207 ? -32.433 -37.839 18.402 1.00 41.39 ? 180 PHE A CE1 1 ATOM 4701 C CE2 . PHE B 1 207 ? -34.751 -38.428 18.855 1.00 40.83 ? 180 PHE A CE2 1 ATOM 4702 C CZ . PHE B 1 207 ? -33.530 -37.918 19.288 1.00 42.43 ? 180 PHE A CZ 1 ATOM 4703 N N . LYS B 1 208 ? -33.818 -37.852 11.917 1.00 58.52 ? 181 LYS A N 1 ATOM 4704 C CA . LYS B 1 208 ? -34.151 -38.014 10.523 1.00 52.78 ? 181 LYS A CA 1 ATOM 4705 C C . LYS B 1 208 ? -33.632 -39.314 9.980 1.00 48.92 ? 181 LYS A C 1 ATOM 4706 O O . LYS B 1 208 ? -34.223 -39.847 9.052 1.00 48.93 ? 181 LYS A O 1 ATOM 4707 C CB . LYS B 1 208 ? -33.564 -36.862 9.715 1.00 55.04 ? 181 LYS A CB 1 ATOM 4708 C CG . LYS B 1 208 ? -34.212 -35.532 10.035 1.00 63.40 ? 181 LYS A CG 1 ATOM 4709 C CD . LYS B 1 208 ? -33.506 -34.407 9.324 1.00 74.53 ? 181 LYS A CD 1 ATOM 4710 C CE . LYS B 1 208 ? -34.394 -33.176 9.267 1.00 80.67 ? 181 LYS A CE 1 ATOM 4711 N NZ . LYS B 1 208 ? -33.655 -32.074 8.574 1.00 87.33 ? 181 LYS A NZ 1 ATOM 4712 N N . SER B 1 209 ? -32.538 -39.836 10.524 1.00 41.18 ? 182 SER A N 1 ATOM 4713 C CA . SER B 1 209 ? -31.879 -40.920 9.835 1.00 40.42 ? 182 SER A CA 1 ATOM 4714 C C . SER B 1 209 ? -31.797 -42.174 10.666 1.00 42.17 ? 182 SER A C 1 ATOM 4715 O O . SER B 1 209 ? -30.953 -43.047 10.378 1.00 41.69 ? 182 SER A O 1 ATOM 4716 C CB . SER B 1 209 ? -30.490 -40.470 9.340 1.00 45.30 ? 182 SER A CB 1 ATOM 4717 O OG . SER B 1 209 ? -29.448 -40.716 10.289 1.00 45.77 ? 182 SER A OG 1 ATOM 4718 N N . PHE B 1 210 ? -32.700 -42.298 11.654 1.00 43.67 ? 183 PHE A N 1 ATOM 4719 C CA . PHE B 1 210 ? -32.628 -43.378 12.642 1.00 42.58 ? 183 PHE A CA 1 ATOM 4720 C C . PHE B 1 210 ? -33.696 -44.398 12.365 1.00 47.46 ? 183 PHE A C 1 ATOM 4721 O O . PHE B 1 210 ? -34.850 -44.026 12.158 1.00 49.22 ? 183 PHE A O 1 ATOM 4722 C CB . PHE B 1 210 ? -32.824 -42.853 14.069 1.00 41.11 ? 183 PHE A CB 1 ATOM 4723 C CG . PHE B 1 210 ? -32.782 -43.932 15.131 1.00 39.84 ? 183 PHE A CG 1 ATOM 4724 C CD1 . PHE B 1 210 ? -33.939 -44.436 15.687 1.00 44.04 ? 183 PHE A CD1 1 ATOM 4725 C CD2 . PHE B 1 210 ? -31.579 -44.429 15.585 1.00 40.34 ? 183 PHE A CD2 1 ATOM 4726 C CE1 . PHE B 1 210 ? -33.889 -45.442 16.681 1.00 44.88 ? 183 PHE A CE1 1 ATOM 4727 C CE2 . PHE B 1 210 ? -31.524 -45.407 16.575 1.00 43.97 ? 183 PHE A CE2 1 ATOM 4728 C CZ . PHE B 1 210 ? -32.687 -45.932 17.118 1.00 41.02 ? 183 PHE A CZ 1 ATOM 4729 N N . LEU B 1 211 ? -33.301 -45.673 12.366 1.00 51.12 ? 184 LEU A N 1 ATOM 4730 C CA . LEU B 1 211 ? -34.231 -46.801 12.378 1.00 52.19 ? 184 LEU A CA 1 ATOM 4731 C C . LEU B 1 211 ? -33.698 -47.868 13.318 1.00 50.26 ? 184 LEU A C 1 ATOM 4732 O O . LEU B 1 211 ? -32.553 -47.787 13.754 1.00 45.27 ? 184 LEU A O 1 ATOM 4733 C CB . LEU B 1 211 ? -34.409 -47.411 11.000 1.00 56.19 ? 184 LEU A CB 1 ATOM 4734 C CG . LEU B 1 211 ? -34.461 -46.407 9.858 1.00 66.84 ? 184 LEU A CG 1 ATOM 4735 C CD1 . LEU B 1 211 ? -33.070 -46.225 9.271 1.00 68.48 ? 184 LEU A CD1 1 ATOM 4736 C CD2 . LEU B 1 211 ? -35.463 -46.834 8.796 1.00 71.21 ? 184 LEU A CD2 1 ATOM 4737 N N . ARG B 1 212 ? -34.532 -48.863 13.632 1.00 45.83 ? 185 ARG A N 1 ATOM 4738 C CA . ARG B 1 212 ? -34.136 -49.876 14.572 1.00 43.67 ? 185 ARG A CA 1 ATOM 4739 C C . ARG B 1 212 ? -34.803 -51.174 14.298 1.00 44.92 ? 185 ARG A C 1 ATOM 4740 O O . ARG B 1 212 ? -35.898 -51.203 13.740 1.00 46.28 ? 185 ARG A O 1 ATOM 4741 C CB . ARG B 1 212 ? -34.456 -49.432 15.972 1.00 42.93 ? 185 ARG A CB 1 ATOM 4742 C CG . ARG B 1 212 ? -35.839 -48.870 16.133 1.00 42.84 ? 185 ARG A CG 1 ATOM 4743 C CD . ARG B 1 212 ? -36.058 -48.524 17.591 1.00 44.31 ? 185 ARG A CD 1 ATOM 4744 N NE . ARG B 1 212 ? -37.072 -47.485 17.767 1.00 42.63 ? 185 ARG A NE 1 ATOM 4745 C CZ . ARG B 1 212 ? -37.115 -46.655 18.801 1.00 43.47 ? 185 ARG A CZ 1 ATOM 4746 N NH1 . ARG B 1 212 ? -36.189 -46.697 19.787 1.00 42.16 ? 185 ARG A NH1 1 ATOM 4747 N NH2 . ARG B 1 212 ? -38.089 -45.759 18.843 1.00 45.75 ? 185 ARG A NH2 1 ATOM 4748 N N . THR B 1 213 ? -34.119 -52.248 14.685 1.00 48.04 ? 186 THR A N 1 ATOM 4749 C CA . THR B 1 213 ? -34.593 -53.618 14.496 1.00 52.69 ? 186 THR A CA 1 ATOM 4750 C C . THR B 1 213 ? -34.978 -54.129 15.867 1.00 56.71 ? 186 THR A C 1 ATOM 4751 O O . THR B 1 213 ? -34.863 -55.323 16.161 1.00 59.13 ? 186 THR A O 1 ATOM 4752 C CB . THR B 1 213 ? -33.484 -54.526 13.965 1.00 54.87 ? 186 THR A CB 1 ATOM 4753 O OG1 . THR B 1 213 ? -32.372 -54.483 14.868 1.00 59.25 ? 186 THR A OG1 1 ATOM 4754 C CG2 . THR B 1 213 ? -33.010 -54.062 12.621 1.00 60.16 ? 186 THR A CG2 1 ATOM 4755 N N . ILE B 1 214 ? -35.393 -53.206 16.724 1.00 54.99 ? 187 ILE A N 1 ATOM 4756 C CA . ILE B 1 214 ? -35.955 -53.560 17.996 1.00 55.50 ? 187 ILE A CA 1 ATOM 4757 C C . ILE B 1 214 ? -37.220 -52.758 18.104 1.00 52.71 ? 187 ILE A C 1 ATOM 4758 O O . ILE B 1 214 ? -37.265 -51.644 17.572 1.00 53.64 ? 187 ILE A O 1 ATOM 4759 C CB . ILE B 1 214 ? -34.993 -53.290 19.167 1.00 56.61 ? 187 ILE A CB 1 ATOM 4760 C CG1 . ILE B 1 214 ? -35.576 -53.887 20.453 1.00 54.28 ? 187 ILE A CG1 1 ATOM 4761 C CG2 . ILE B 1 214 ? -34.670 -51.807 19.306 1.00 57.47 ? 187 ILE A CG2 1 ATOM 4762 C CD1 . ILE B 1 214 ? -34.556 -54.062 21.554 1.00 56.01 ? 187 ILE A CD1 1 ATOM 4763 N N . PRO B 1 215 ? -38.275 -53.347 18.713 1.00 51.11 ? 188 PRO A N 1 ATOM 4764 C CA . PRO B 1 215 ? -39.502 -52.578 18.977 1.00 52.48 ? 188 PRO A CA 1 ATOM 4765 C C . PRO B 1 215 ? -39.287 -51.503 20.026 1.00 48.60 ? 188 PRO A C 1 ATOM 4766 O O . PRO B 1 215 ? -38.479 -51.680 20.942 1.00 54.40 ? 188 PRO A O 1 ATOM 4767 C CB . PRO B 1 215 ? -40.488 -53.627 19.512 1.00 53.53 ? 188 PRO A CB 1 ATOM 4768 C CG . PRO B 1 215 ? -39.876 -54.959 19.217 1.00 51.58 ? 188 PRO A CG 1 ATOM 4769 C CD . PRO B 1 215 ? -38.398 -54.739 19.179 1.00 49.97 ? 188 PRO A CD 1 ATOM 4770 N N . ASN B 1 216 ? -40.006 -50.397 19.907 1.00 51.87 ? 189 ASN A N 1 ATOM 4771 C CA . ASN B 1 216 ? -39.917 -49.369 20.934 1.00 51.48 ? 189 ASN A CA 1 ATOM 4772 C C . ASN B 1 216 ? -40.739 -49.773 22.132 1.00 46.45 ? 189 ASN A C 1 ATOM 4773 O O . ASN B 1 216 ? -41.538 -50.684 22.055 1.00 51.26 ? 189 ASN A O 1 ATOM 4774 C CB . ASN B 1 216 ? -40.264 -47.992 20.390 1.00 52.19 ? 189 ASN A CB 1 ATOM 4775 C CG . ASN B 1 216 ? -41.719 -47.695 20.439 1.00 54.58 ? 189 ASN A CG 1 ATOM 4776 O OD1 . ASN B 1 216 ? -42.406 -48.140 21.337 1.00 63.69 ? 189 ASN A OD1 1 ATOM 4777 N ND2 . ASN B 1 216 ? -42.194 -46.886 19.505 1.00 58.66 ? 189 ASN A ND2 1 ATOM 4778 N N . ASP B 1 217 ? -40.512 -49.113 23.250 1.00 51.14 ? 190 ASP A N 1 ATOM 4779 C CA . ASP B 1 217 ? -41.033 -49.565 24.539 1.00 54.13 ? 190 ASP A CA 1 ATOM 4780 C C . ASP B 1 217 ? -42.480 -49.220 24.869 1.00 54.84 ? 190 ASP A C 1 ATOM 4781 O O . ASP B 1 217 ? -43.011 -49.651 25.914 1.00 58.08 ? 190 ASP A O 1 ATOM 4782 C CB . ASP B 1 217 ? -40.110 -49.077 25.651 1.00 55.30 ? 190 ASP A CB 1 ATOM 4783 C CG . ASP B 1 217 ? -38.770 -49.806 25.630 1.00 62.65 ? 190 ASP A CG 1 ATOM 4784 O OD1 . ASP B 1 217 ? -38.801 -51.054 25.519 1.00 59.27 ? 190 ASP A OD1 1 ATOM 4785 O OD2 . ASP B 1 217 ? -37.696 -49.143 25.703 1.00 77.24 ? 190 ASP A OD2 1 ATOM 4786 N N . GLU B 1 218 ? -43.137 -48.478 23.993 1.00 52.27 ? 191 GLU A N 1 ATOM 4787 C CA . GLU B 1 218 ? -44.516 -48.113 24.244 1.00 58.61 ? 191 GLU A CA 1 ATOM 4788 C C . GLU B 1 218 ? -45.327 -49.326 24.728 1.00 59.78 ? 191 GLU A C 1 ATOM 4789 O O . GLU B 1 218 ? -45.991 -49.258 25.754 1.00 65.15 ? 191 GLU A O 1 ATOM 4790 C CB . GLU B 1 218 ? -45.114 -47.489 22.990 1.00 63.81 ? 191 GLU A CB 1 ATOM 4791 C CG . GLU B 1 218 ? -44.440 -46.182 22.590 1.00 66.58 ? 191 GLU A CG 1 ATOM 4792 C CD . GLU B 1 218 ? -44.718 -45.089 23.583 1.00 65.50 ? 191 GLU A CD 1 ATOM 4793 O OE1 . GLU B 1 218 ? -45.748 -44.429 23.366 1.00 75.41 ? 191 GLU A OE1 1 ATOM 4794 O OE2 . GLU B 1 218 ? -43.952 -44.930 24.572 1.00 65.25 ? 191 GLU A OE2 1 ATOM 4795 N N . HIS B 1 219 ? -45.217 -50.452 24.031 1.00 58.32 ? 192 HIS A N 1 ATOM 4796 C CA . HIS B 1 219 ? -45.998 -51.637 24.384 1.00 57.89 ? 192 HIS A CA 1 ATOM 4797 C C . HIS B 1 219 ? -45.523 -52.305 25.647 1.00 57.61 ? 192 HIS A C 1 ATOM 4798 O O . HIS B 1 219 ? -46.318 -52.703 26.467 1.00 63.44 ? 192 HIS A O 1 ATOM 4799 C CB . HIS B 1 219 ? -45.985 -52.676 23.266 1.00 60.45 ? 192 HIS A CB 1 ATOM 4800 C CG . HIS B 1 219 ? -47.022 -52.436 22.214 1.00 56.96 ? 192 HIS A CG 1 ATOM 4801 N ND1 . HIS B 1 219 ? -48.374 -52.452 22.487 1.00 60.53 ? 192 HIS A ND1 1 ATOM 4802 C CD2 . HIS B 1 219 ? -46.903 -52.181 20.893 1.00 54.92 ? 192 HIS A CD2 1 ATOM 4803 C CE1 . HIS B 1 219 ? -49.043 -52.203 21.375 1.00 60.80 ? 192 HIS A CE1 1 ATOM 4804 N NE2 . HIS B 1 219 ? -48.172 -52.036 20.395 1.00 58.67 ? 192 HIS A NE2 1 ATOM 4805 N N . GLN B 1 220 ? -44.223 -52.458 25.783 1.00 55.80 ? 193 GLN A N 1 ATOM 4806 C CA . GLN B 1 220 ? -43.656 -53.042 26.968 1.00 49.52 ? 193 GLN A CA 1 ATOM 4807 C C . GLN B 1 220 ? -44.144 -52.365 28.232 1.00 49.14 ? 193 GLN A C 1 ATOM 4808 O O . GLN B 1 220 ? -44.436 -53.028 29.199 1.00 52.17 ? 193 GLN A O 1 ATOM 4809 C CB . GLN B 1 220 ? -42.140 -52.926 26.929 1.00 58.63 ? 193 GLN A CB 1 ATOM 4810 C CG . GLN B 1 220 ? -41.474 -54.066 27.650 1.00 65.22 ? 193 GLN A CG 1 ATOM 4811 C CD . GLN B 1 220 ? -39.986 -53.905 27.771 1.00 61.89 ? 193 GLN A CD 1 ATOM 4812 O OE1 . GLN B 1 220 ? -39.279 -53.713 26.801 1.00 73.05 ? 193 GLN A OE1 1 ATOM 4813 N NE2 . GLN B 1 220 ? -39.510 -54.010 28.977 1.00 64.24 ? 193 GLN A NE2 1 ATOM 4814 N N . ALA B 1 221 ? -44.216 -51.041 28.246 1.00 50.53 ? 194 ALA A N 1 ATOM 4815 C CA . ALA B 1 221 ? -44.590 -50.329 29.469 1.00 47.99 ? 194 ALA A CA 1 ATOM 4816 C C . ALA B 1 221 ? -46.074 -50.499 29.702 1.00 48.48 ? 194 ALA A C 1 ATOM 4817 O O . ALA B 1 221 ? -46.522 -50.526 30.844 1.00 51.45 ? 194 ALA A O 1 ATOM 4818 C CB . ALA B 1 221 ? -44.242 -48.846 29.370 1.00 50.13 ? 194 ALA A CB 1 ATOM 4819 N N . THR B 1 222 ? -46.838 -50.597 28.618 1.00 46.68 ? 195 THR A N 1 ATOM 4820 C CA . THR B 1 222 ? -48.248 -50.896 28.734 1.00 48.68 ? 195 THR A CA 1 ATOM 4821 C C . THR B 1 222 ? -48.403 -52.349 29.278 1.00 50.45 ? 195 THR A C 1 ATOM 4822 O O . THR B 1 222 ? -49.236 -52.605 30.163 1.00 46.35 ? 195 THR A O 1 ATOM 4823 C CB . THR B 1 222 ? -48.997 -50.717 27.383 1.00 49.39 ? 195 THR A CB 1 ATOM 4824 O OG1 . THR B 1 222 ? -48.633 -49.480 26.743 1.00 49.07 ? 195 THR A OG1 1 ATOM 4825 C CG2 . THR B 1 222 ? -50.491 -50.728 27.611 1.00 46.91 ? 195 THR A CG2 1 ATOM 4826 N N . ALA B 1 223 ? -47.584 -53.282 28.782 1.00 46.11 ? 196 ALA A N 1 ATOM 4827 C CA . ALA B 1 223 ? -47.677 -54.667 29.205 1.00 47.80 ? 196 ALA A CA 1 ATOM 4828 C C . ALA B 1 223 ? -47.513 -54.706 30.690 1.00 51.24 ? 196 ALA A C 1 ATOM 4829 O O . ALA B 1 223 ? -48.276 -55.370 31.397 1.00 49.13 ? 196 ALA A O 1 ATOM 4830 C CB . ALA B 1 223 ? -46.608 -55.519 28.565 1.00 49.70 ? 196 ALA A CB 1 ATOM 4831 N N . MET B 1 224 ? -46.510 -53.986 31.173 1.00 51.17 ? 197 MET A N 1 ATOM 4832 C CA . MET B 1 224 ? -46.275 -53.969 32.595 1.00 52.42 ? 197 MET A CA 1 ATOM 4833 C C . MET B 1 224 ? -47.548 -53.603 33.349 1.00 53.48 ? 197 MET A C 1 ATOM 4834 O O . MET B 1 224 ? -47.849 -54.214 34.375 1.00 50.33 ? 197 MET A O 1 ATOM 4835 C CB . MET B 1 224 ? -45.173 -52.990 32.953 1.00 55.93 ? 197 MET A CB 1 ATOM 4836 C CG . MET B 1 224 ? -43.824 -53.633 33.153 1.00 58.03 ? 197 MET A CG 1 ATOM 4837 S SD . MET B 1 224 ? -42.524 -52.435 32.853 1.00 69.95 ? 197 MET A SD 1 ATOM 4838 C CE . MET B 1 224 ? -41.113 -53.529 33.022 1.00 85.50 ? 197 MET A CE 1 ATOM 4839 N N . ALA B 1 225 ? -48.288 -52.604 32.850 1.00 48.19 ? 198 ALA A N 1 ATOM 4840 C CA . ALA B 1 225 ? -49.458 -52.131 33.572 1.00 46.34 ? 198 ALA A CA 1 ATOM 4841 C C . ALA B 1 225 ? -50.596 -53.146 33.416 1.00 51.05 ? 198 ALA A C 1 ATOM 4842 O O . ALA B 1 225 ? -51.386 -53.314 34.317 1.00 49.87 ? 198 ALA A O 1 ATOM 4843 C CB . ALA B 1 225 ? -49.866 -50.740 33.109 1.00 45.64 ? 198 ALA A CB 1 ATOM 4844 N N . ASP B 1 226 ? -50.650 -53.842 32.279 1.00 54.40 ? 199 ASP A N 1 ATOM 4845 C CA . ASP B 1 226 ? -51.580 -54.961 32.106 1.00 52.61 ? 199 ASP A CA 1 ATOM 4846 C C . ASP B 1 226 ? -51.322 -56.074 33.127 1.00 52.77 ? 199 ASP A C 1 ATOM 4847 O O . ASP B 1 226 ? -52.260 -56.630 33.678 1.00 57.42 ? 199 ASP A O 1 ATOM 4848 C CB . ASP B 1 226 ? -51.554 -55.505 30.661 1.00 45.71 ? 199 ASP A CB 1 ATOM 4849 C CG . ASP B 1 226 ? -52.385 -54.649 29.714 1.00 51.00 ? 199 ASP A CG 1 ATOM 4850 O OD1 . ASP B 1 226 ? -53.166 -53.807 30.211 1.00 58.63 ? 199 ASP A OD1 1 ATOM 4851 O OD2 . ASP B 1 226 ? -52.274 -54.774 28.480 1.00 55.25 ? 199 ASP A OD2 1 ATOM 4852 N N . ILE B 1 227 ? -50.059 -56.373 33.393 1.00 50.01 ? 200 ILE A N 1 ATOM 4853 C CA . ILE B 1 227 ? -49.711 -57.411 34.339 1.00 52.49 ? 200 ILE A CA 1 ATOM 4854 C C . ILE B 1 227 ? -50.206 -57.010 35.731 1.00 56.37 ? 200 ILE A C 1 ATOM 4855 O O . ILE B 1 227 ? -50.875 -57.782 36.416 1.00 57.25 ? 200 ILE A O 1 ATOM 4856 C CB . ILE B 1 227 ? -48.195 -57.699 34.306 1.00 52.23 ? 200 ILE A CB 1 ATOM 4857 C CG1 . ILE B 1 227 ? -47.843 -58.470 33.038 1.00 55.17 ? 200 ILE A CG1 1 ATOM 4858 C CG2 . ILE B 1 227 ? -47.743 -58.487 35.514 1.00 53.47 ? 200 ILE A CG2 1 ATOM 4859 C CD1 . ILE B 1 227 ? -46.351 -58.597 32.780 1.00 59.82 ? 200 ILE A CD1 1 ATOM 4860 N N . ILE B 1 228 ? -49.914 -55.791 36.147 1.00 59.13 ? 201 ILE A N 1 ATOM 4861 C CA . ILE B 1 228 ? -50.409 -55.312 37.454 1.00 58.15 ? 201 ILE A CA 1 ATOM 4862 C C . ILE B 1 228 ? -51.939 -55.333 37.610 1.00 54.36 ? 201 ILE A C 1 ATOM 4863 O O . ILE B 1 228 ? -52.426 -55.839 38.605 1.00 52.51 ? 201 ILE A O 1 ATOM 4864 C CB . ILE B 1 228 ? -49.854 -53.918 37.753 1.00 57.67 ? 201 ILE A CB 1 ATOM 4865 C CG1 . ILE B 1 228 ? -48.369 -54.059 38.099 1.00 54.22 ? 201 ILE A CG1 1 ATOM 4866 C CG2 . ILE B 1 228 ? -50.626 -53.244 38.879 1.00 56.70 ? 201 ILE A CG2 1 ATOM 4867 C CD1 . ILE B 1 228 ? -47.591 -52.810 37.817 1.00 55.30 ? 201 ILE A CD1 1 ATOM 4868 N N . GLU B 1 229 ? -52.678 -54.779 36.643 1.00 55.72 ? 202 GLU A N 1 ATOM 4869 C CA . GLU B 1 229 ? -54.160 -54.889 36.577 1.00 57.79 ? 202 GLU A CA 1 ATOM 4870 C C . GLU B 1 229 ? -54.590 -56.348 36.773 1.00 54.95 ? 202 GLU A C 1 ATOM 4871 O O . GLU B 1 229 ? -55.386 -56.653 37.648 1.00 45.53 ? 202 GLU A O 1 ATOM 4872 C CB . GLU B 1 229 ? -54.681 -54.351 35.229 1.00 62.09 ? 202 GLU A CB 1 ATOM 4873 C CG . GLU B 1 229 ? -56.198 -54.226 35.072 1.00 70.09 ? 202 GLU A CG 1 ATOM 4874 C CD . GLU B 1 229 ? -56.635 -53.602 33.718 1.00 73.19 ? 202 GLU A CD 1 ATOM 4875 O OE1 . GLU B 1 229 ? -57.657 -52.886 33.660 1.00 81.19 ? 202 GLU A OE1 1 ATOM 4876 O OE2 . GLU B 1 229 ? -55.974 -53.812 32.687 1.00 67.61 ? 202 GLU A OE2 1 ATOM 4877 N N . TYR B 1 230 ? -53.983 -57.252 36.010 1.00 55.50 ? 203 TYR A N 1 ATOM 4878 C CA . TYR B 1 230 ? -54.320 -58.673 36.067 1.00 57.31 ? 203 TYR A CA 1 ATOM 4879 C C . TYR B 1 230 ? -54.304 -59.256 37.473 1.00 54.21 ? 203 TYR A C 1 ATOM 4880 O O . TYR B 1 230 ? -55.262 -59.891 37.873 1.00 54.05 ? 203 TYR A O 1 ATOM 4881 C CB . TYR B 1 230 ? -53.371 -59.484 35.194 1.00 59.23 ? 203 TYR A CB 1 ATOM 4882 C CG . TYR B 1 230 ? -53.720 -60.946 35.082 1.00 64.45 ? 203 TYR A CG 1 ATOM 4883 C CD1 . TYR B 1 230 ? -54.659 -61.381 34.153 1.00 68.21 ? 203 TYR A CD1 1 ATOM 4884 C CD2 . TYR B 1 230 ? -53.100 -61.901 35.889 1.00 62.41 ? 203 TYR A CD2 1 ATOM 4885 C CE1 . TYR B 1 230 ? -54.982 -62.726 34.041 1.00 70.75 ? 203 TYR A CE1 1 ATOM 4886 C CE2 . TYR B 1 230 ? -53.408 -63.244 35.768 1.00 65.72 ? 203 TYR A CE2 1 ATOM 4887 C CZ . TYR B 1 230 ? -54.350 -63.653 34.841 1.00 66.04 ? 203 TYR A CZ 1 ATOM 4888 O OH . TYR B 1 230 ? -54.676 -64.978 34.697 1.00 65.96 ? 203 TYR A OH 1 ATOM 4889 N N . PHE B 1 231 ? -53.214 -59.062 38.205 1.00 53.82 ? 204 PHE A N 1 ATOM 4890 C CA . PHE B 1 231 ? -53.113 -59.565 39.578 1.00 53.15 ? 204 PHE A CA 1 ATOM 4891 C C . PHE B 1 231 ? -53.761 -58.639 40.607 1.00 55.44 ? 204 PHE A C 1 ATOM 4892 O O . PHE B 1 231 ? -53.683 -58.897 41.804 1.00 57.05 ? 204 PHE A O 1 ATOM 4893 C CB . PHE B 1 231 ? -51.646 -59.809 39.963 1.00 56.27 ? 204 PHE A CB 1 ATOM 4894 C CG . PHE B 1 231 ? -51.009 -60.950 39.240 1.00 53.28 ? 204 PHE A CG 1 ATOM 4895 C CD1 . PHE B 1 231 ? -51.135 -62.249 39.723 1.00 51.74 ? 204 PHE A CD1 1 ATOM 4896 C CD2 . PHE B 1 231 ? -50.288 -60.732 38.085 1.00 54.71 ? 204 PHE A CD2 1 ATOM 4897 C CE1 . PHE B 1 231 ? -50.557 -63.316 39.065 1.00 53.07 ? 204 PHE A CE1 1 ATOM 4898 C CE2 . PHE B 1 231 ? -49.689 -61.795 37.413 1.00 58.25 ? 204 PHE A CE2 1 ATOM 4899 C CZ . PHE B 1 231 ? -49.826 -63.086 37.904 1.00 60.90 ? 204 PHE A CZ 1 ATOM 4900 N N . ARG B 1 232 ? -54.392 -57.550 40.157 1.00 62.63 ? 205 ARG A N 1 ATOM 4901 C CA . ARG B 1 232 ? -55.073 -56.615 41.071 1.00 59.58 ? 205 ARG A CA 1 ATOM 4902 C C . ARG B 1 232 ? -54.132 -55.985 42.102 1.00 58.19 ? 205 ARG A C 1 ATOM 4903 O O . ARG B 1 232 ? -54.547 -55.662 43.209 1.00 52.86 ? 205 ARG A O 1 ATOM 4904 C CB . ARG B 1 232 ? -56.188 -57.329 41.813 1.00 61.15 ? 205 ARG A CB 1 ATOM 4905 C CG . ARG B 1 232 ? -56.801 -58.479 41.047 1.00 66.92 ? 205 ARG A CG 1 ATOM 4906 C CD . ARG B 1 232 ? -57.749 -58.087 39.926 1.00 62.06 ? 205 ARG A CD 1 ATOM 4907 N NE . ARG B 1 232 ? -58.393 -59.324 39.489 1.00 61.34 ? 205 ARG A NE 1 ATOM 4908 C CZ . ARG B 1 232 ? -59.380 -59.402 38.623 1.00 65.41 ? 205 ARG A CZ 1 ATOM 4909 N NH1 . ARG B 1 232 ? -59.862 -58.327 38.036 1.00 81.03 ? 205 ARG A NH1 1 ATOM 4910 N NH2 . ARG B 1 232 ? -59.873 -60.575 38.331 1.00 73.42 ? 205 ARG A NH2 1 ATOM 4911 N N . TRP B 1 233 ? -52.860 -55.848 41.735 1.00 60.51 ? 206 TRP A N 1 ATOM 4912 C CA . TRP B 1 233 ? -51.897 -55.099 42.514 1.00 59.18 ? 206 TRP A CA 1 ATOM 4913 C C . TRP B 1 233 ? -52.224 -53.632 42.426 1.00 58.45 ? 206 TRP A C 1 ATOM 4914 O O . TRP B 1 233 ? -52.857 -53.188 41.470 1.00 66.63 ? 206 TRP A O 1 ATOM 4915 C CB . TRP B 1 233 ? -50.497 -55.375 42.015 1.00 60.15 ? 206 TRP A CB 1 ATOM 4916 C CG . TRP B 1 233 ? -50.098 -56.801 42.240 1.00 66.10 ? 206 TRP A CG 1 ATOM 4917 C CD1 . TRP B 1 233 ? -50.535 -57.627 43.233 1.00 64.49 ? 206 TRP A CD1 1 ATOM 4918 C CD2 . TRP B 1 233 ? -49.166 -57.562 41.474 1.00 63.59 ? 206 TRP A CD2 1 ATOM 4919 N NE1 . TRP B 1 233 ? -49.927 -58.840 43.136 1.00 62.56 ? 206 TRP A NE1 1 ATOM 4920 C CE2 . TRP B 1 233 ? -49.095 -58.838 42.054 1.00 63.36 ? 206 TRP A CE2 1 ATOM 4921 C CE3 . TRP B 1 233 ? -48.394 -57.293 40.349 1.00 62.97 ? 206 TRP A CE3 1 ATOM 4922 C CZ2 . TRP B 1 233 ? -48.282 -59.842 41.552 1.00 61.25 ? 206 TRP A CZ2 1 ATOM 4923 C CZ3 . TRP B 1 233 ? -47.586 -58.293 39.849 1.00 65.43 ? 206 TRP A CZ3 1 ATOM 4924 C CH2 . TRP B 1 233 ? -47.535 -59.552 40.456 1.00 62.23 ? 206 TRP A CH2 1 ATOM 4925 N N . ASN B 1 234 ? -51.796 -52.879 43.421 1.00 55.37 ? 207 ASN A N 1 ATOM 4926 C CA . ASN B 1 234 ? -52.529 -51.694 43.766 1.00 65.54 ? 207 ASN A CA 1 ATOM 4927 C C . ASN B 1 234 ? -51.739 -50.468 44.064 1.00 73.86 ? 207 ASN A C 1 ATOM 4928 O O . ASN B 1 234 ? -52.260 -49.386 43.694 1.00 82.37 ? 207 ASN A O 1 ATOM 4929 C CB . ASN B 1 234 ? -53.405 -51.962 44.987 1.00 82.39 ? 207 ASN A CB 1 ATOM 4930 N N . TRP B 1 235 ? -50.577 -50.587 44.765 1.00 56.20 ? 208 TRP A N 1 ATOM 4931 C CA . TRP B 1 235 ? -49.761 -49.369 45.143 1.00 58.63 ? 208 TRP A CA 1 ATOM 4932 C C . TRP B 1 235 ? -48.294 -49.611 44.937 1.00 58.59 ? 208 TRP A C 1 ATOM 4933 O O . TRP B 1 235 ? -47.545 -49.861 45.888 1.00 58.34 ? 208 TRP A O 1 ATOM 4934 C CB . TRP B 1 235 ? -49.964 -48.913 46.617 1.00 61.76 ? 208 TRP A CB 1 ATOM 4935 C CG . TRP B 1 235 ? -51.092 -47.978 46.829 1.00 56.93 ? 208 TRP A CG 1 ATOM 4936 C CD1 . TRP B 1 235 ? -52.385 -48.311 47.077 1.00 56.55 ? 208 TRP A CD1 1 ATOM 4937 C CD2 . TRP B 1 235 ? -51.044 -46.547 46.766 1.00 63.00 ? 208 TRP A CD2 1 ATOM 4938 N NE1 . TRP B 1 235 ? -53.159 -47.176 47.179 1.00 60.71 ? 208 TRP A NE1 1 ATOM 4939 C CE2 . TRP B 1 235 ? -52.360 -46.075 46.991 1.00 63.56 ? 208 TRP A CE2 1 ATOM 4940 C CE3 . TRP B 1 235 ? -50.020 -45.613 46.543 1.00 62.27 ? 208 TRP A CE3 1 ATOM 4941 C CZ2 . TRP B 1 235 ? -52.681 -44.701 47.006 1.00 61.26 ? 208 TRP A CZ2 1 ATOM 4942 C CZ3 . TRP B 1 235 ? -50.340 -44.251 46.563 1.00 62.69 ? 208 TRP A CZ3 1 ATOM 4943 C CH2 . TRP B 1 235 ? -51.664 -43.810 46.788 1.00 60.72 ? 208 TRP A CH2 1 ATOM 4944 N N . VAL B 1 236 ? -47.864 -49.500 43.693 1.00 55.85 ? 209 VAL A N 1 ATOM 4945 C CA . VAL B 1 236 ? -46.562 -50.023 43.287 1.00 48.21 ? 209 VAL A CA 1 ATOM 4946 C C . VAL B 1 236 ? -45.441 -48.987 43.364 1.00 49.27 ? 209 VAL A C 1 ATOM 4947 O O . VAL B 1 236 ? -45.684 -47.778 43.411 1.00 52.04 ? 209 VAL A O 1 ATOM 4948 C CB . VAL B 1 236 ? -46.711 -50.604 41.891 1.00 49.65 ? 209 VAL A CB 1 ATOM 4949 C CG1 . VAL B 1 236 ? -47.939 -51.505 41.883 1.00 47.72 ? 209 VAL A CG1 1 ATOM 4950 C CG2 . VAL B 1 236 ? -46.880 -49.502 40.848 1.00 53.83 ? 209 VAL A CG2 1 ATOM 4951 N N . GLY B 1 237 ? -44.212 -49.476 43.428 1.00 49.44 ? 210 GLY A N 1 ATOM 4952 C CA . GLY B 1 237 ? -43.010 -48.637 43.385 1.00 46.05 ? 210 GLY A CA 1 ATOM 4953 C C . GLY B 1 237 ? -42.462 -48.561 41.966 1.00 47.39 ? 210 GLY A C 1 ATOM 4954 O O . GLY B 1 237 ? -42.714 -49.448 41.137 1.00 42.49 ? 210 GLY A O 1 ATOM 4955 N N . THR B 1 238 ? -41.758 -47.470 41.659 1.00 48.45 ? 211 THR A N 1 ATOM 4956 C CA . THR B 1 238 ? -41.102 -47.350 40.371 1.00 47.07 ? 211 THR A CA 1 ATOM 4957 C C . THR B 1 238 ? -39.683 -46.888 40.484 1.00 48.09 ? 211 THR A C 1 ATOM 4958 O O . THR B 1 238 ? -39.357 -45.991 41.276 1.00 42.39 ? 211 THR A O 1 ATOM 4959 C CB . THR B 1 238 ? -41.846 -46.460 39.358 1.00 48.81 ? 211 THR A CB 1 ATOM 4960 O OG1 . THR B 1 238 ? -41.981 -45.123 39.838 1.00 53.56 ? 211 THR A OG1 1 ATOM 4961 C CG2 . THR B 1 238 ? -43.225 -47.030 39.060 1.00 51.67 ? 211 THR A CG2 1 ATOM 4962 N N . ILE B 1 239 ? -38.835 -47.533 39.682 1.00 46.72 ? 212 ILE A N 1 ATOM 4963 C CA . ILE B 1 239 ? -37.434 -47.196 39.604 1.00 46.62 ? 212 ILE A CA 1 ATOM 4964 C C . ILE B 1 239 ? -36.994 -47.222 38.150 1.00 45.36 ? 212 ILE A C 1 ATOM 4965 O O . ILE B 1 239 ? -37.283 -48.165 37.404 1.00 43.27 ? 212 ILE A O 1 ATOM 4966 C CB . ILE B 1 239 ? -36.608 -48.170 40.443 1.00 48.88 ? 212 ILE A CB 1 ATOM 4967 C CG1 . ILE B 1 239 ? -36.898 -47.942 41.925 1.00 49.91 ? 212 ILE A CG1 1 ATOM 4968 C CG2 . ILE B 1 239 ? -35.131 -47.959 40.232 1.00 48.52 ? 212 ILE A CG2 1 ATOM 4969 C CD1 . ILE B 1 239 ? -36.547 -49.148 42.759 1.00 52.78 ? 212 ILE A CD1 1 ATOM 4970 N N . ALA B 1 240 ? -36.284 -46.170 37.756 1.00 46.23 ? 213 ALA A N 1 ATOM 4971 C CA . ALA B 1 240 ? -35.836 -46.004 36.381 1.00 44.41 ? 213 ALA A CA 1 ATOM 4972 C C . ALA B 1 240 ? -34.433 -45.434 36.290 1.00 44.71 ? 213 ALA A C 1 ATOM 4973 O O . ALA B 1 240 ? -34.075 -44.495 37.025 1.00 44.89 ? 213 ALA A O 1 ATOM 4974 C CB . ALA B 1 240 ? -36.782 -45.079 35.669 1.00 50.05 ? 213 ALA A CB 1 ATOM 4975 N N . ALA B 1 241 ? -33.632 -45.994 35.386 1.00 43.95 ? 214 ALA A N 1 ATOM 4976 C CA . ALA B 1 241 ? -32.366 -45.363 35.020 1.00 41.05 ? 214 ALA A CA 1 ATOM 4977 C C . ALA B 1 241 ? -32.594 -43.925 34.570 1.00 38.00 ? 214 ALA A C 1 ATOM 4978 O O . ALA B 1 241 ? -33.429 -43.670 33.740 1.00 38.93 ? 214 ALA A O 1 ATOM 4979 C CB . ALA B 1 241 ? -31.691 -46.129 33.912 1.00 39.30 ? 214 ALA A CB 1 ATOM 4980 N N . ASP B 1 242 ? -31.831 -42.994 35.118 1.00 38.60 ? 215 ASP A N 1 ATOM 4981 C CA . ASP B 1 242 ? -31.839 -41.600 34.670 1.00 40.66 ? 215 ASP A CA 1 ATOM 4982 C C . ASP B 1 242 ? -31.246 -41.333 33.265 1.00 44.52 ? 215 ASP A C 1 ATOM 4983 O O . ASP B 1 242 ? -30.187 -40.711 33.120 1.00 45.26 ? 215 ASP A O 1 ATOM 4984 C CB . ASP B 1 242 ? -31.123 -40.703 35.681 1.00 38.67 ? 215 ASP A CB 1 ATOM 4985 C CG . ASP B 1 242 ? -31.679 -39.274 35.677 1.00 45.12 ? 215 ASP A CG 1 ATOM 4986 O OD1 . ASP B 1 242 ? -32.611 -38.967 34.903 1.00 52.14 ? 215 ASP A OD1 1 ATOM 4987 O OD2 . ASP B 1 242 ? -31.230 -38.443 36.476 1.00 49.70 ? 215 ASP A OD2 1 ATOM 4988 N N . ASP B 1 243 ? -31.973 -41.724 32.231 1.00 44.72 ? 216 ASP A N 1 ATOM 4989 C CA . ASP B 1 243 ? -31.497 -41.542 30.873 1.00 47.52 ? 216 ASP A CA 1 ATOM 4990 C C . ASP B 1 243 ? -32.663 -41.673 29.920 1.00 48.95 ? 216 ASP A C 1 ATOM 4991 O O . ASP B 1 243 ? -33.812 -41.674 30.357 1.00 53.75 ? 216 ASP A O 1 ATOM 4992 C CB . ASP B 1 243 ? -30.414 -42.572 30.558 1.00 53.18 ? 216 ASP A CB 1 ATOM 4993 C CG . ASP B 1 243 ? -30.910 -44.008 30.682 1.00 59.07 ? 216 ASP A CG 1 ATOM 4994 O OD1 . ASP B 1 243 ? -31.965 -44.359 30.116 1.00 63.86 ? 216 ASP A OD1 1 ATOM 4995 O OD2 . ASP B 1 243 ? -30.236 -44.793 31.357 1.00 73.02 ? 216 ASP A OD2 1 ATOM 4996 N N . ASP B 1 244 ? -32.397 -41.822 28.626 1.00 48.68 ? 217 ASP A N 1 ATOM 4997 C CA . ASP B 1 244 ? -33.475 -41.744 27.668 1.00 45.87 ? 217 ASP A CA 1 ATOM 4998 C C . ASP B 1 244 ? -34.139 -43.066 27.503 1.00 47.17 ? 217 ASP A C 1 ATOM 4999 O O . ASP B 1 244 ? -35.105 -43.154 26.744 1.00 48.49 ? 217 ASP A O 1 ATOM 5000 C CB . ASP B 1 244 ? -32.974 -41.210 26.327 1.00 50.02 ? 217 ASP A CB 1 ATOM 5001 C CG . ASP B 1 244 ? -32.695 -39.699 26.360 1.00 55.11 ? 217 ASP A CG 1 ATOM 5002 O OD1 . ASP B 1 244 ? -33.251 -39.004 27.260 1.00 59.54 ? 217 ASP A OD1 1 ATOM 5003 O OD2 . ASP B 1 244 ? -31.931 -39.203 25.487 1.00 54.97 ? 217 ASP A OD2 1 ATOM 5004 N N . TYR B 1 245 ? -33.645 -44.107 28.191 1.00 46.76 ? 218 TYR A N 1 ATOM 5005 C CA . TYR B 1 245 ? -34.332 -45.412 28.193 1.00 44.99 ? 218 TYR A CA 1 ATOM 5006 C C . TYR B 1 245 ? -35.299 -45.472 29.347 1.00 42.55 ? 218 TYR A C 1 ATOM 5007 O O . TYR B 1 245 ? -36.463 -45.754 29.151 1.00 44.35 ? 218 TYR A O 1 ATOM 5008 C CB . TYR B 1 245 ? -33.355 -46.582 28.231 1.00 43.20 ? 218 TYR A CB 1 ATOM 5009 C CG . TYR B 1 245 ? -33.959 -47.961 28.491 1.00 47.47 ? 218 TYR A CG 1 ATOM 5010 C CD1 . TYR B 1 245 ? -34.772 -48.574 27.547 1.00 45.19 ? 218 TYR A CD1 1 ATOM 5011 C CD2 . TYR B 1 245 ? -33.689 -48.671 29.683 1.00 49.65 ? 218 TYR A CD2 1 ATOM 5012 C CE1 . TYR B 1 245 ? -35.329 -49.818 27.783 1.00 46.75 ? 218 TYR A CE1 1 ATOM 5013 C CE2 . TYR B 1 245 ? -34.235 -49.952 29.914 1.00 46.12 ? 218 TYR A CE2 1 ATOM 5014 C CZ . TYR B 1 245 ? -35.052 -50.519 28.965 1.00 44.85 ? 218 TYR A CZ 1 ATOM 5015 O OH . TYR B 1 245 ? -35.613 -51.778 29.138 1.00 43.73 ? 218 TYR A OH 1 ATOM 5016 N N . GLY B 1 246 ? -34.811 -45.159 30.532 1.00 44.86 ? 219 GLY A N 1 ATOM 5017 C CA . GLY B 1 246 ? -35.568 -45.338 31.760 1.00 44.88 ? 219 GLY A CA 1 ATOM 5018 C C . GLY B 1 246 ? -36.647 -44.306 31.959 1.00 44.81 ? 219 GLY A C 1 ATOM 5019 O O . GLY B 1 246 ? -37.806 -44.665 32.099 1.00 50.07 ? 219 GLY A O 1 ATOM 5020 N N . ARG B 1 247 ? -36.293 -43.027 31.943 1.00 42.70 ? 220 ARG A N 1 ATOM 5021 C CA . ARG B 1 247 ? -37.304 -41.966 32.099 1.00 43.26 ? 220 ARG A CA 1 ATOM 5022 C C . ARG B 1 247 ? -38.518 -42.125 31.162 1.00 44.54 ? 220 ARG A C 1 ATOM 5023 O O . ARG B 1 247 ? -39.656 -42.054 31.627 1.00 51.99 ? 220 ARG A O 1 ATOM 5024 C CB . ARG B 1 247 ? -36.701 -40.554 31.975 1.00 39.85 ? 220 ARG A CB 1 ATOM 5025 C CG . ARG B 1 247 ? -35.635 -40.257 33.036 1.00 43.73 ? 220 ARG A CG 1 ATOM 5026 C CD . ARG B 1 247 ? -35.142 -38.816 33.008 1.00 42.74 ? 220 ARG A CD 1 ATOM 5027 N NE . ARG B 1 247 ? -34.727 -38.453 31.678 1.00 43.68 ? 220 ARG A NE 1 ATOM 5028 C CZ . ARG B 1 247 ? -33.470 -38.382 31.292 1.00 50.25 ? 220 ARG A CZ 1 ATOM 5029 N NH1 . ARG B 1 247 ? -32.491 -38.613 32.150 1.00 57.28 ? 220 ARG A NH1 1 ATOM 5030 N NH2 . ARG B 1 247 ? -33.186 -38.069 30.043 1.00 54.76 ? 220 ARG A NH2 1 ATOM 5031 N N . PRO B 1 248 ? -38.297 -42.328 29.849 1.00 42.98 ? 221 PRO A N 1 ATOM 5032 C CA . PRO B 1 248 ? -39.481 -42.371 29.017 1.00 43.49 ? 221 PRO A CA 1 ATOM 5033 C C . PRO B 1 248 ? -40.299 -43.617 29.172 1.00 41.23 ? 221 PRO A C 1 ATOM 5034 O O . PRO B 1 248 ? -41.496 -43.580 28.947 1.00 51.08 ? 221 PRO A O 1 ATOM 5035 C CB . PRO B 1 248 ? -38.924 -42.279 27.587 1.00 41.04 ? 221 PRO A CB 1 ATOM 5036 C CG . PRO B 1 248 ? -37.622 -41.676 27.721 1.00 39.76 ? 221 PRO A CG 1 ATOM 5037 C CD . PRO B 1 248 ? -37.089 -42.181 29.030 1.00 42.00 ? 221 PRO A CD 1 ATOM 5038 N N . GLY B 1 249 ? -39.656 -44.718 29.501 1.00 41.58 ? 222 GLY A N 1 ATOM 5039 C CA . GLY B 1 249 ? -40.366 -45.953 29.750 1.00 42.18 ? 222 GLY A CA 1 ATOM 5040 C C . GLY B 1 249 ? -41.248 -45.812 30.967 1.00 47.26 ? 222 GLY A C 1 ATOM 5041 O O . GLY B 1 249 ? -42.398 -46.199 30.955 1.00 54.45 ? 222 GLY A O 1 ATOM 5042 N N . ILE B 1 250 ? -40.721 -45.247 32.038 1.00 49.31 ? 223 ILE A N 1 ATOM 5043 C CA . ILE B 1 250 ? -41.516 -45.120 33.232 1.00 50.59 ? 223 ILE A CA 1 ATOM 5044 C C . ILE B 1 250 ? -42.588 -44.051 33.056 1.00 49.58 ? 223 ILE A C 1 ATOM 5045 O O . ILE B 1 250 ? -43.633 -44.136 33.681 1.00 52.48 ? 223 ILE A O 1 ATOM 5046 C CB . ILE B 1 250 ? -40.647 -44.881 34.502 1.00 55.00 ? 223 ILE A CB 1 ATOM 5047 C CG1 . ILE B 1 250 ? -41.219 -45.652 35.694 1.00 60.27 ? 223 ILE A CG1 1 ATOM 5048 C CG2 . ILE B 1 250 ? -40.561 -43.417 34.878 1.00 57.12 ? 223 ILE A CG2 1 ATOM 5049 C CD1 . ILE B 1 250 ? -41.025 -47.159 35.599 1.00 59.80 ? 223 ILE A CD1 1 ATOM 5050 N N . GLU B 1 251 ? -42.336 -43.042 32.228 1.00 46.42 ? 224 GLU A N 1 ATOM 5051 C CA . GLU B 1 251 ? -43.325 -42.003 31.997 1.00 49.69 ? 224 GLU A CA 1 ATOM 5052 C C . GLU B 1 251 ? -44.505 -42.657 31.275 1.00 47.43 ? 224 GLU A C 1 ATOM 5053 O O . GLU B 1 251 ? -45.667 -42.354 31.542 1.00 43.70 ? 224 GLU A O 1 ATOM 5054 C CB . GLU B 1 251 ? -42.693 -40.810 31.233 1.00 58.66 ? 224 GLU A CB 1 ATOM 5055 C CG . GLU B 1 251 ? -43.523 -40.105 30.144 1.00 67.09 ? 224 GLU A CG 1 ATOM 5056 C CD . GLU B 1 251 ? -42.767 -40.000 28.791 1.00 85.17 ? 224 GLU A CD 1 ATOM 5057 O OE1 . GLU B 1 251 ? -42.646 -41.050 28.062 1.00 84.29 ? 224 GLU A OE1 1 ATOM 5058 O OE2 . GLU B 1 251 ? -42.291 -38.873 28.444 1.00 77.23 ? 224 GLU A OE2 1 ATOM 5059 N N . LYS B 1 252 ? -44.202 -43.604 30.396 1.00 45.63 ? 225 LYS A N 1 ATOM 5060 C CA . LYS B 1 252 ? -45.252 -44.308 29.688 1.00 46.04 ? 225 LYS A CA 1 ATOM 5061 C C . LYS B 1 252 ? -45.987 -45.225 30.642 1.00 43.90 ? 225 LYS A C 1 ATOM 5062 O O . LYS B 1 252 ? -47.201 -45.242 30.677 1.00 44.23 ? 225 LYS A O 1 ATOM 5063 C CB . LYS B 1 252 ? -44.702 -45.093 28.512 1.00 45.30 ? 225 LYS A CB 1 ATOM 5064 C CG . LYS B 1 252 ? -45.746 -45.966 27.834 1.00 47.57 ? 225 LYS A CG 1 ATOM 5065 C CD . LYS B 1 252 ? -46.817 -45.123 27.191 1.00 47.26 ? 225 LYS A CD 1 ATOM 5066 C CE . LYS B 1 252 ? -47.689 -45.951 26.244 1.00 50.69 ? 225 LYS A CE 1 ATOM 5067 N NZ . LYS B 1 252 ? -48.874 -45.132 25.842 1.00 51.05 ? 225 LYS A NZ 1 ATOM 5068 N N . PHE B 1 253 ? -45.243 -45.973 31.427 1.00 44.94 ? 226 PHE A N 1 ATOM 5069 C CA . PHE B 1 253 ? -45.845 -46.799 32.435 1.00 49.40 ? 226 PHE A CA 1 ATOM 5070 C C . PHE B 1 253 ? -46.798 -46.025 33.320 1.00 48.92 ? 226 PHE A C 1 ATOM 5071 O O . PHE B 1 253 ? -47.830 -46.524 33.686 1.00 52.78 ? 226 PHE A O 1 ATOM 5072 C CB . PHE B 1 253 ? -44.807 -47.448 33.345 1.00 52.09 ? 226 PHE A CB 1 ATOM 5073 C CG . PHE B 1 253 ? -45.431 -48.158 34.503 1.00 51.44 ? 226 PHE A CG 1 ATOM 5074 C CD1 . PHE B 1 253 ? -46.227 -49.298 34.291 1.00 50.96 ? 226 PHE A CD1 1 ATOM 5075 C CD2 . PHE B 1 253 ? -45.314 -47.661 35.782 1.00 52.49 ? 226 PHE A CD2 1 ATOM 5076 C CE1 . PHE B 1 253 ? -46.858 -49.944 35.351 1.00 48.29 ? 226 PHE A CE1 1 ATOM 5077 C CE2 . PHE B 1 253 ? -45.936 -48.312 36.856 1.00 54.03 ? 226 PHE A CE2 1 ATOM 5078 C CZ . PHE B 1 253 ? -46.709 -49.449 36.636 1.00 49.72 ? 226 PHE A CZ 1 ATOM 5079 N N . ARG B 1 254 ? -46.451 -44.814 33.682 1.00 52.78 ? 227 ARG A N 1 ATOM 5080 C CA . ARG B 1 254 ? -47.296 -44.058 34.598 1.00 57.82 ? 227 ARG A CA 1 ATOM 5081 C C . ARG B 1 254 ? -48.588 -43.668 33.942 1.00 48.89 ? 227 ARG A C 1 ATOM 5082 O O . ARG B 1 254 ? -49.604 -43.649 34.576 1.00 54.61 ? 227 ARG A O 1 ATOM 5083 C CB . ARG B 1 254 ? -46.579 -42.813 35.087 1.00 63.77 ? 227 ARG A CB 1 ATOM 5084 C CG . ARG B 1 254 ? -47.388 -41.993 36.050 1.00 67.84 ? 227 ARG A CG 1 ATOM 5085 C CD . ARG B 1 254 ? -46.539 -40.901 36.693 1.00 70.34 ? 227 ARG A CD 1 ATOM 5086 N NE . ARG B 1 254 ? -46.783 -40.904 38.140 1.00 71.54 ? 227 ARG A NE 1 ATOM 5087 C CZ . ARG B 1 254 ? -45.894 -41.221 39.068 1.00 65.03 ? 227 ARG A CZ 1 ATOM 5088 N NH1 . ARG B 1 254 ? -44.646 -41.529 38.755 1.00 69.08 ? 227 ARG A NH1 1 ATOM 5089 N NH2 . ARG B 1 254 ? -46.255 -41.189 40.337 1.00 73.34 ? 227 ARG A NH2 1 ATOM 5090 N N . GLU B 1 255 ? -48.555 -43.357 32.663 1.00 53.40 ? 228 GLU A N 1 ATOM 5091 C CA . GLU B 1 255 ? -49.780 -42.967 31.942 1.00 54.95 ? 228 GLU A CA 1 ATOM 5092 C C . GLU B 1 255 ? -50.765 -44.117 31.889 1.00 54.83 ? 228 GLU A C 1 ATOM 5093 O O . GLU B 1 255 ? -51.958 -43.932 32.063 1.00 51.72 ? 228 GLU A O 1 ATOM 5094 C CB . GLU B 1 255 ? -49.429 -42.551 30.538 1.00 53.31 ? 228 GLU A CB 1 ATOM 5095 C CG . GLU B 1 255 ? -50.582 -42.251 29.625 1.00 56.45 ? 228 GLU A CG 1 ATOM 5096 C CD . GLU B 1 255 ? -50.130 -42.238 28.177 1.00 69.88 ? 228 GLU A CD 1 ATOM 5097 O OE1 . GLU B 1 255 ? -49.054 -41.651 27.880 1.00 75.84 ? 228 GLU A OE1 1 ATOM 5098 O OE2 . GLU B 1 255 ? -50.831 -42.841 27.334 1.00 82.59 ? 228 GLU A OE2 1 ATOM 5099 N N . GLU B 1 256 ? -50.231 -45.301 31.630 1.00 57.66 ? 229 GLU A N 1 ATOM 5100 C CA . GLU B 1 256 ? -51.000 -46.523 31.569 1.00 54.28 ? 229 GLU A CA 1 ATOM 5101 C C . GLU B 1 256 ? -51.464 -46.944 32.935 1.00 52.54 ? 229 GLU A C 1 ATOM 5102 O O . GLU B 1 256 ? -52.494 -47.552 33.058 1.00 59.25 ? 229 GLU A O 1 ATOM 5103 C CB . GLU B 1 256 ? -50.148 -47.635 30.992 1.00 56.82 ? 229 GLU A CB 1 ATOM 5104 C CG . GLU B 1 256 ? -49.681 -47.342 29.602 1.00 58.91 ? 229 GLU A CG 1 ATOM 5105 C CD . GLU B 1 256 ? -50.842 -47.068 28.700 1.00 65.84 ? 229 GLU A CD 1 ATOM 5106 O OE1 . GLU B 1 256 ? -51.831 -47.821 28.772 1.00 67.93 ? 229 GLU A OE1 1 ATOM 5107 O OE2 . GLU B 1 256 ? -50.780 -46.091 27.929 1.00 75.37 ? 229 GLU A OE2 1 ATOM 5108 N N . ALA B 1 257 ? -50.701 -46.641 33.965 1.00 49.95 ? 230 ALA A N 1 ATOM 5109 C CA . ALA B 1 257 ? -51.139 -46.960 35.305 1.00 52.26 ? 230 ALA A CA 1 ATOM 5110 C C . ALA B 1 257 ? -52.293 -46.058 35.673 1.00 52.82 ? 230 ALA A C 1 ATOM 5111 O O . ALA B 1 257 ? -53.190 -46.502 36.366 1.00 58.29 ? 230 ALA A O 1 ATOM 5112 C CB . ALA B 1 257 ? -50.006 -46.803 36.314 1.00 54.08 ? 230 ALA A CB 1 ATOM 5113 N N . GLU B 1 258 ? -52.273 -44.801 35.227 1.00 50.82 ? 231 GLU A N 1 ATOM 5114 C CA . GLU B 1 258 ? -53.365 -43.876 35.542 1.00 56.53 ? 231 GLU A CA 1 ATOM 5115 C C . GLU B 1 258 ? -54.668 -44.342 34.874 1.00 61.84 ? 231 GLU A C 1 ATOM 5116 O O . GLU B 1 258 ? -55.705 -44.391 35.526 1.00 73.59 ? 231 GLU A O 1 ATOM 5117 C CB . GLU B 1 258 ? -53.039 -42.423 35.163 1.00 54.94 ? 231 GLU A CB 1 ATOM 5118 N N . GLU B 1 259 ? -54.608 -44.753 33.610 1.00 63.45 ? 232 GLU A N 1 ATOM 5119 C CA . GLU B 1 259 ? -55.798 -45.236 32.890 1.00 63.77 ? 232 GLU A CA 1 ATOM 5120 C C . GLU B 1 259 ? -56.463 -46.449 33.545 1.00 62.26 ? 232 GLU A C 1 ATOM 5121 O O . GLU B 1 259 ? -57.621 -46.746 33.236 1.00 64.14 ? 232 GLU A O 1 ATOM 5122 C CB . GLU B 1 259 ? -55.466 -45.554 31.418 1.00 68.85 ? 232 GLU A CB 1 ATOM 5123 C CG . GLU B 1 259 ? -55.502 -44.319 30.507 1.00 84.73 ? 232 GLU A CG 1 ATOM 5124 C CD . GLU B 1 259 ? -54.547 -44.386 29.302 1.00 99.61 ? 232 GLU A CD 1 ATOM 5125 O OE1 . GLU B 1 259 ? -54.312 -45.511 28.799 1.00 102.78 ? 232 GLU A OE1 1 ATOM 5126 O OE2 . GLU B 1 259 ? -54.041 -43.315 28.845 1.00 94.58 ? 232 GLU A OE2 1 ATOM 5127 N N . ARG B 1 260 ? -55.727 -47.140 34.424 1.00 59.20 ? 233 ARG A N 1 ATOM 5128 C CA . ARG B 1 260 ? -56.164 -48.385 35.075 1.00 53.37 ? 233 ARG A CA 1 ATOM 5129 C C . ARG B 1 260 ? -56.352 -48.226 36.587 1.00 57.20 ? 233 ARG A C 1 ATOM 5130 O O . ARG B 1 260 ? -56.492 -49.191 37.338 1.00 55.94 ? 233 ARG A O 1 ATOM 5131 C CB . ARG B 1 260 ? -55.137 -49.464 34.787 1.00 48.98 ? 233 ARG A CB 1 ATOM 5132 C CG . ARG B 1 260 ? -55.137 -49.897 33.338 1.00 47.52 ? 233 ARG A CG 1 ATOM 5133 C CD . ARG B 1 260 ? -53.977 -50.821 33.067 1.00 51.77 ? 233 ARG A CD 1 ATOM 5134 N NE . ARG B 1 260 ? -53.904 -51.240 31.660 1.00 56.05 ? 233 ARG A NE 1 ATOM 5135 C CZ . ARG B 1 260 ? -53.547 -50.467 30.642 1.00 51.83 ? 233 ARG A CZ 1 ATOM 5136 N NH1 . ARG B 1 260 ? -53.228 -49.194 30.799 1.00 57.56 ? 233 ARG A NH1 1 ATOM 5137 N NH2 . ARG B 1 260 ? -53.519 -50.969 29.446 1.00 53.56 ? 233 ARG A NH2 1 ATOM 5138 N N . ASP B 1 261 ? -56.343 -46.986 37.039 1.00 59.07 ? 234 ASP A N 1 ATOM 5139 C CA . ASP B 1 261 ? -56.497 -46.703 38.446 1.00 61.46 ? 234 ASP A CA 1 ATOM 5140 C C . ASP B 1 261 ? -55.501 -47.486 39.318 1.00 53.84 ? 234 ASP A C 1 ATOM 5141 O O . ASP B 1 261 ? -55.857 -47.927 40.379 1.00 56.68 ? 234 ASP A O 1 ATOM 5142 C CB . ASP B 1 261 ? -57.959 -46.932 38.877 1.00 63.85 ? 234 ASP A CB 1 ATOM 5143 C CG . ASP B 1 261 ? -58.951 -46.044 38.115 1.00 74.75 ? 234 ASP A CG 1 ATOM 5144 O OD1 . ASP B 1 261 ? -58.629 -44.869 37.817 1.00 89.44 ? 234 ASP A OD1 1 ATOM 5145 O OD2 . ASP B 1 261 ? -60.065 -46.515 37.800 1.00 84.97 ? 234 ASP A OD2 1 ATOM 5146 N N . ILE B 1 262 ? -54.254 -47.603 38.858 1.00 51.10 ? 235 ILE A N 1 ATOM 5147 C CA . ILE B 1 262 ? -53.129 -48.194 39.613 1.00 50.62 ? 235 ILE A CA 1 ATOM 5148 C C . ILE B 1 262 ? -52.315 -47.065 40.164 1.00 47.23 ? 235 ILE A C 1 ATOM 5149 O O . ILE B 1 262 ? -51.841 -46.242 39.391 1.00 46.93 ? 235 ILE A O 1 ATOM 5150 C CB . ILE B 1 262 ? -52.174 -48.963 38.685 1.00 53.28 ? 235 ILE A CB 1 ATOM 5151 C CG1 . ILE B 1 262 ? -52.803 -50.278 38.257 1.00 55.69 ? 235 ILE A CG1 1 ATOM 5152 C CG2 . ILE B 1 262 ? -50.813 -49.206 39.327 1.00 53.59 ? 235 ILE A CG2 1 ATOM 5153 C CD1 . ILE B 1 262 ? -52.341 -50.700 36.874 1.00 58.84 ? 235 ILE A CD1 1 HETATM 5154 N N . CSO B 1 263 ? -52.115 -47.064 41.474 1.00 48.41 ? 236 CSO A N 1 HETATM 5155 C CA . CSO B 1 263 ? -51.468 -45.973 42.178 1.00 51.90 ? 236 CSO A CA 1 HETATM 5156 C CB . CSO B 1 263 ? -52.126 -45.743 43.551 1.00 57.85 ? 236 CSO A CB 1 HETATM 5157 S SG . CSO B 1 263 ? -53.825 -45.246 43.421 1.00 65.15 ? 236 CSO A SG 1 HETATM 5158 C C . CSO B 1 263 ? -50.025 -46.304 42.399 1.00 52.99 ? 236 CSO A C 1 HETATM 5159 O O . CSO B 1 263 ? -49.680 -47.451 42.638 1.00 59.82 ? 236 CSO A O 1 HETATM 5160 O OD . CSO B 1 263 ? -53.739 -43.524 43.136 1.00 77.11 ? 236 CSO A OD 1 ATOM 5161 N N . ILE B 1 264 ? -49.181 -45.272 42.377 1.00 55.72 ? 237 ILE A N 1 ATOM 5162 C CA . ILE B 1 264 ? -47.734 -45.392 42.532 1.00 51.38 ? 237 ILE A CA 1 ATOM 5163 C C . ILE B 1 264 ? -47.260 -44.790 43.852 1.00 49.72 ? 237 ILE A C 1 ATOM 5164 O O . ILE B 1 264 ? -47.460 -43.605 44.088 1.00 46.44 ? 237 ILE A O 1 ATOM 5165 C CB . ILE B 1 264 ? -47.050 -44.687 41.336 1.00 49.38 ? 237 ILE A CB 1 ATOM 5166 C CG1 . ILE B 1 264 ? -47.540 -45.359 40.052 1.00 51.92 ? 237 ILE A CG1 1 ATOM 5167 C CG2 . ILE B 1 264 ? -45.519 -44.734 41.455 1.00 47.02 ? 237 ILE A CG2 1 ATOM 5168 C CD1 . ILE B 1 264 ? -46.913 -44.806 38.793 1.00 60.14 ? 237 ILE A CD1 1 ATOM 5169 N N . ASP B 1 265 ? -46.606 -45.579 44.702 1.00 53.17 ? 238 ASP A N 1 ATOM 5170 C CA . ASP B 1 265 ? -46.185 -45.051 46.023 1.00 61.82 ? 238 ASP A CA 1 ATOM 5171 C C . ASP B 1 265 ? -44.891 -44.229 45.967 1.00 56.51 ? 238 ASP A C 1 ATOM 5172 O O . ASP B 1 265 ? -44.717 -43.274 46.710 1.00 62.65 ? 238 ASP A O 1 ATOM 5173 C CB . ASP B 1 265 ? -46.071 -46.152 47.112 1.00 63.43 ? 238 ASP A CB 1 ATOM 5174 C CG . ASP B 1 265 ? -45.832 -45.557 48.527 1.00 72.35 ? 238 ASP A CG 1 ATOM 5175 O OD1 . ASP B 1 265 ? -46.507 -44.556 48.896 1.00 75.45 ? 238 ASP A OD1 1 ATOM 5176 O OD2 . ASP B 1 265 ? -44.948 -46.059 49.264 1.00 81.44 ? 238 ASP A OD2 1 ATOM 5177 N N . PHE B 1 266 ? -43.984 -44.604 45.093 1.00 54.70 ? 239 PHE A N 1 ATOM 5178 C CA . PHE B 1 266 ? -42.742 -43.878 44.970 1.00 54.35 ? 239 PHE A CA 1 ATOM 5179 C C . PHE B 1 266 ? -42.183 -44.037 43.548 1.00 50.01 ? 239 PHE A C 1 ATOM 5180 O O . PHE B 1 266 ? -42.569 -44.994 42.821 1.00 48.79 ? 239 PHE A O 1 ATOM 5181 C CB . PHE B 1 266 ? -41.740 -44.371 46.039 1.00 54.32 ? 239 PHE A CB 1 ATOM 5182 C CG . PHE B 1 266 ? -41.249 -45.788 45.832 1.00 53.13 ? 239 PHE A CG 1 ATOM 5183 C CD1 . PHE B 1 266 ? -40.388 -46.112 44.774 1.00 54.00 ? 239 PHE A CD1 1 ATOM 5184 C CD2 . PHE B 1 266 ? -41.596 -46.795 46.725 1.00 52.51 ? 239 PHE A CD2 1 ATOM 5185 C CE1 . PHE B 1 266 ? -39.903 -47.405 44.605 1.00 51.47 ? 239 PHE A CE1 1 ATOM 5186 C CE2 . PHE B 1 266 ? -41.129 -48.090 46.547 1.00 53.53 ? 239 PHE A CE2 1 ATOM 5187 C CZ . PHE B 1 266 ? -40.277 -48.394 45.489 1.00 53.44 ? 239 PHE A CZ 1 ATOM 5188 N N . SER B 1 267 ? -41.299 -43.112 43.170 1.00 40.64 ? 240 SER A N 1 ATOM 5189 C CA . SER B 1 267 ? -40.545 -43.228 41.925 1.00 46.24 ? 240 SER A CA 1 ATOM 5190 C C . SER B 1 267 ? -39.125 -42.620 41.998 1.00 46.00 ? 240 SER A C 1 ATOM 5191 O O . SER B 1 267 ? -38.938 -41.430 42.145 1.00 42.53 ? 240 SER A O 1 ATOM 5192 C CB . SER B 1 267 ? -41.336 -42.612 40.770 1.00 52.14 ? 240 SER A CB 1 ATOM 5193 O OG . SER B 1 267 ? -41.516 -41.243 41.001 1.00 62.41 ? 240 SER A OG 1 ATOM 5194 N N . GLU B 1 268 ? -38.111 -43.461 41.922 1.00 49.10 ? 241 GLU A N 1 ATOM 5195 C CA . GLU B 1 268 ? -36.759 -43.001 42.085 1.00 48.99 ? 241 GLU A CA 1 ATOM 5196 C C . GLU B 1 268 ? -35.965 -43.192 40.807 1.00 46.87 ? 241 GLU A C 1 ATOM 5197 O O . GLU B 1 268 ? -36.342 -44.000 39.974 1.00 51.46 ? 241 GLU A O 1 ATOM 5198 C CB . GLU B 1 268 ? -36.109 -43.732 43.255 1.00 53.39 ? 241 GLU A CB 1 ATOM 5199 C CG . GLU B 1 268 ? -36.777 -43.458 44.609 1.00 58.45 ? 241 GLU A CG 1 ATOM 5200 C CD . GLU B 1 268 ? -36.950 -41.971 44.940 1.00 61.94 ? 241 GLU A CD 1 ATOM 5201 O OE1 . GLU B 1 268 ? -38.081 -41.527 45.248 1.00 67.03 ? 241 GLU A OE1 1 ATOM 5202 O OE2 . GLU B 1 268 ? -35.954 -41.238 44.890 1.00 72.26 ? 241 GLU A OE2 1 ATOM 5203 N N . LEU B 1 269 ? -34.894 -42.410 40.654 1.00 47.06 ? 242 LEU A N 1 ATOM 5204 C CA . LEU B 1 269 ? -33.965 -42.534 39.544 1.00 51.64 ? 242 LEU A CA 1 ATOM 5205 C C . LEU B 1 269 ? -32.621 -43.131 40.002 1.00 52.14 ? 242 LEU A C 1 ATOM 5206 O O . LEU B 1 269 ? -32.211 -42.956 41.144 1.00 49.86 ? 242 LEU A O 1 ATOM 5207 C CB . LEU B 1 269 ? -33.766 -41.174 38.890 1.00 54.99 ? 242 LEU A CB 1 ATOM 5208 C CG . LEU B 1 269 ? -35.048 -40.580 38.285 1.00 59.95 ? 242 LEU A CG 1 ATOM 5209 C CD1 . LEU B 1 269 ? -34.791 -39.183 37.741 1.00 60.86 ? 242 LEU A CD1 1 ATOM 5210 C CD2 . LEU B 1 269 ? -35.641 -41.454 37.191 1.00 56.81 ? 242 LEU A CD2 1 ATOM 5211 N N . ILE B 1 270 ? -31.964 -43.873 39.120 1.00 49.92 ? 243 ILE A N 1 ATOM 5212 C CA . ILE B 1 270 ? -30.666 -44.484 39.431 1.00 51.90 ? 243 ILE A CA 1 ATOM 5213 C C . ILE B 1 270 ? -29.757 -44.428 38.219 1.00 51.90 ? 243 ILE A C 1 ATOM 5214 O O . ILE B 1 270 ? -30.199 -44.130 37.129 1.00 55.90 ? 243 ILE A O 1 ATOM 5215 C CB . ILE B 1 270 ? -30.800 -45.979 39.839 1.00 53.39 ? 243 ILE A CB 1 ATOM 5216 C CG1 . ILE B 1 270 ? -31.546 -46.787 38.768 1.00 52.28 ? 243 ILE A CG1 1 ATOM 5217 C CG2 . ILE B 1 270 ? -31.537 -46.105 41.145 1.00 56.67 ? 243 ILE A CG2 1 ATOM 5218 C CD1 . ILE B 1 270 ? -31.583 -48.267 39.037 1.00 51.66 ? 243 ILE A CD1 1 ATOM 5219 N N . SER B 1 271 ? -28.499 -44.790 38.411 1.00 54.56 ? 244 SER A N 1 ATOM 5220 C CA . SER B 1 271 ? -27.484 -44.781 37.356 1.00 54.16 ? 244 SER A CA 1 ATOM 5221 C C . SER B 1 271 ? -26.280 -45.663 37.731 1.00 51.94 ? 244 SER A C 1 ATOM 5222 O O . SER B 1 271 ? -25.916 -45.789 38.906 1.00 50.07 ? 244 SER A O 1 ATOM 5223 C CB . SER B 1 271 ? -27.005 -43.322 37.136 1.00 54.40 ? 244 SER A CB 1 ATOM 5224 O OG . SER B 1 271 ? -25.710 -43.260 36.545 1.00 52.55 ? 244 SER A OG 1 ATOM 5225 N N . GLN B 1 272 ? -25.606 -46.205 36.731 1.00 52.88 ? 245 GLN A N 1 ATOM 5226 C CA . GLN B 1 272 ? -24.284 -46.823 36.952 1.00 51.21 ? 245 GLN A CA 1 ATOM 5227 C C . GLN B 1 272 ? -23.394 -45.945 37.815 1.00 51.70 ? 245 GLN A C 1 ATOM 5228 O O . GLN B 1 272 ? -22.762 -46.455 38.717 1.00 54.07 ? 245 GLN A O 1 ATOM 5229 C CB . GLN B 1 272 ? -23.628 -47.070 35.621 1.00 54.26 ? 245 GLN A CB 1 ATOM 5230 C CG . GLN B 1 272 ? -22.248 -47.663 35.606 1.00 56.91 ? 245 GLN A CG 1 ATOM 5231 C CD . GLN B 1 272 ? -21.905 -48.159 34.201 1.00 65.83 ? 245 GLN A CD 1 ATOM 5232 O OE1 . GLN B 1 272 ? -22.696 -48.011 33.255 1.00 77.60 ? 245 GLN A OE1 1 ATOM 5233 N NE2 . GLN B 1 272 ? -20.740 -48.744 34.057 1.00 61.06 ? 245 GLN A NE2 1 ATOM 5234 N N . TYR B 1 273 ? -23.398 -44.622 37.602 1.00 54.21 ? 246 TYR A N 1 ATOM 5235 C CA . TYR B 1 273 ? -22.457 -43.712 38.307 1.00 53.58 ? 246 TYR A CA 1 ATOM 5236 C C . TYR B 1 273 ? -22.997 -42.990 39.521 1.00 55.62 ? 246 TYR A C 1 ATOM 5237 O O . TYR B 1 273 ? -22.417 -41.992 39.943 1.00 55.85 ? 246 TYR A O 1 ATOM 5238 C CB . TYR B 1 273 ? -21.876 -42.698 37.325 1.00 50.55 ? 246 TYR A CB 1 ATOM 5239 C CG . TYR B 1 273 ? -21.266 -43.428 36.187 1.00 50.48 ? 246 TYR A CG 1 ATOM 5240 C CD1 . TYR B 1 273 ? -20.003 -43.992 36.311 1.00 49.57 ? 246 TYR A CD1 1 ATOM 5241 C CD2 . TYR B 1 273 ? -21.998 -43.677 35.029 1.00 50.73 ? 246 TYR A CD2 1 ATOM 5242 C CE1 . TYR B 1 273 ? -19.444 -44.721 35.275 1.00 50.28 ? 246 TYR A CE1 1 ATOM 5243 C CE2 . TYR B 1 273 ? -21.469 -44.425 33.995 1.00 51.47 ? 246 TYR A CE2 1 ATOM 5244 C CZ . TYR B 1 273 ? -20.190 -44.940 34.112 1.00 51.95 ? 246 TYR A CZ 1 ATOM 5245 O OH . TYR B 1 273 ? -19.657 -45.663 33.066 1.00 50.82 ? 246 TYR A OH 1 ATOM 5246 N N . SER B 1 274 ? -24.081 -43.492 40.103 1.00 58.99 ? 247 SER A N 1 ATOM 5247 C CA . SER B 1 274 ? -24.639 -42.864 41.314 1.00 62.85 ? 247 SER A CA 1 ATOM 5248 C C . SER B 1 274 ? -23.707 -43.061 42.504 1.00 62.40 ? 247 SER A C 1 ATOM 5249 O O . SER B 1 274 ? -23.282 -44.172 42.770 1.00 62.05 ? 247 SER A O 1 ATOM 5250 C CB . SER B 1 274 ? -26.004 -43.480 41.657 1.00 65.18 ? 247 SER A CB 1 ATOM 5251 O OG . SER B 1 274 ? -26.842 -43.564 40.513 1.00 69.51 ? 247 SER A OG 1 ATOM 5252 N N . ASP B 1 275 ? -23.407 -41.998 43.239 1.00 63.82 ? 248 ASP A N 1 ATOM 5253 C CA . ASP B 1 275 ? -22.644 -42.146 44.481 1.00 62.22 ? 248 ASP A CA 1 ATOM 5254 C C . ASP B 1 275 ? -23.416 -42.885 45.600 1.00 62.54 ? 248 ASP A C 1 ATOM 5255 O O . ASP B 1 275 ? -24.608 -43.178 45.468 1.00 59.19 ? 248 ASP A O 1 ATOM 5256 C CB . ASP B 1 275 ? -22.126 -40.779 44.958 1.00 67.72 ? 248 ASP A CB 1 ATOM 5257 C CG . ASP B 1 275 ? -23.227 -39.838 45.426 1.00 74.42 ? 248 ASP A CG 1 ATOM 5258 O OD1 . ASP B 1 275 ? -24.275 -40.303 45.936 1.00 82.56 ? 248 ASP A OD1 1 ATOM 5259 O OD2 . ASP B 1 275 ? -23.019 -38.609 45.307 1.00 81.20 ? 248 ASP A OD2 1 ATOM 5260 N N . GLU B 1 276 ? -22.728 -43.159 46.705 1.00 62.94 ? 249 GLU A N 1 ATOM 5261 C CA . GLU B 1 276 ? -23.296 -43.943 47.806 1.00 65.62 ? 249 GLU A CA 1 ATOM 5262 C C . GLU B 1 276 ? -24.474 -43.242 48.509 1.00 65.33 ? 249 GLU A C 1 ATOM 5263 O O . GLU B 1 276 ? -25.398 -43.918 49.000 1.00 68.50 ? 249 GLU A O 1 ATOM 5264 C CB . GLU B 1 276 ? -22.202 -44.345 48.824 1.00 64.23 ? 249 GLU A CB 1 ATOM 5265 N N . GLU B 1 277 ? -24.456 -41.911 48.553 1.00 61.77 ? 250 GLU A N 1 ATOM 5266 C CA . GLU B 1 277 ? -25.544 -41.164 49.204 1.00 68.20 ? 250 GLU A CA 1 ATOM 5267 C C . GLU B 1 277 ? -26.835 -41.335 48.411 1.00 70.32 ? 250 GLU A C 1 ATOM 5268 O O . GLU B 1 277 ? -27.908 -41.508 48.983 1.00 76.70 ? 250 GLU A O 1 ATOM 5269 C CB . GLU B 1 277 ? -25.203 -39.670 49.368 1.00 65.94 ? 250 GLU A CB 1 ATOM 5270 N N . GLU B 1 278 ? -26.711 -41.321 47.089 1.00 71.53 ? 251 GLU A N 1 ATOM 5271 C CA . GLU B 1 278 ? -27.862 -41.460 46.200 1.00 68.21 ? 251 GLU A CA 1 ATOM 5272 C C . GLU B 1 278 ? -28.440 -42.853 46.234 1.00 61.39 ? 251 GLU A C 1 ATOM 5273 O O . GLU B 1 278 ? -29.619 -43.016 46.018 1.00 59.80 ? 251 GLU A O 1 ATOM 5274 C CB . GLU B 1 278 ? -27.486 -41.089 44.755 1.00 74.00 ? 251 GLU A CB 1 ATOM 5275 C CG . GLU B 1 278 ? -27.257 -39.583 44.529 1.00 77.36 ? 251 GLU A CG 1 ATOM 5276 C CD . GLU B 1 278 ? -26.329 -39.259 43.351 1.00 80.87 ? 251 GLU A CD 1 ATOM 5277 O OE1 . GLU B 1 278 ? -25.391 -40.053 43.038 1.00 75.56 ? 251 GLU A OE1 1 ATOM 5278 O OE2 . GLU B 1 278 ? -26.536 -38.189 42.735 1.00 76.42 ? 251 GLU A OE2 1 ATOM 5279 N N . ILE B 1 279 ? -27.614 -43.860 46.494 1.00 60.49 ? 252 ILE A N 1 ATOM 5280 C CA . ILE B 1 279 ? -28.105 -45.215 46.587 1.00 57.06 ? 252 ILE A CA 1 ATOM 5281 C C . ILE B 1 279 ? -28.777 -45.406 47.922 1.00 63.68 ? 252 ILE A C 1 ATOM 5282 O O . ILE B 1 279 ? -29.882 -45.957 47.982 1.00 74.75 ? 252 ILE A O 1 ATOM 5283 C CB . ILE B 1 279 ? -26.999 -46.267 46.464 1.00 58.89 ? 252 ILE A CB 1 ATOM 5284 C CG1 . ILE B 1 279 ? -26.230 -46.106 45.160 1.00 61.46 ? 252 ILE A CG1 1 ATOM 5285 C CG2 . ILE B 1 279 ? -27.604 -47.666 46.530 1.00 62.61 ? 252 ILE A CG2 1 ATOM 5286 C CD1 . ILE B 1 279 ? -27.111 -46.131 43.928 1.00 65.91 ? 252 ILE A CD1 1 ATOM 5287 N N . GLN B 1 280 ? -28.118 -44.963 48.994 1.00 63.43 ? 253 GLN A N 1 ATOM 5288 C CA . GLN B 1 280 ? -28.678 -45.143 50.336 1.00 67.54 ? 253 GLN A CA 1 ATOM 5289 C C . GLN B 1 280 ? -30.092 -44.618 50.312 1.00 61.67 ? 253 GLN A C 1 ATOM 5290 O O . GLN B 1 280 ? -31.003 -45.270 50.804 1.00 65.47 ? 253 GLN A O 1 ATOM 5291 C CB . GLN B 1 280 ? -27.855 -44.443 51.443 1.00 70.07 ? 253 GLN A CB 1 ATOM 5292 N N . HIS B 1 281 ? -30.273 -43.456 49.691 1.00 61.60 ? 254 HIS A N 1 ATOM 5293 C CA . HIS B 1 281 ? -31.573 -42.818 49.639 1.00 56.69 ? 254 HIS A CA 1 ATOM 5294 C C . HIS B 1 281 ? -32.621 -43.693 48.938 1.00 58.66 ? 254 HIS A C 1 ATOM 5295 O O . HIS B 1 281 ? -33.750 -43.810 49.423 1.00 59.63 ? 254 HIS A O 1 ATOM 5296 C CB . HIS B 1 281 ? -31.473 -41.470 48.955 1.00 55.80 ? 254 HIS A CB 1 ATOM 5297 C CG . HIS B 1 281 ? -32.784 -40.767 48.862 1.00 64.52 ? 254 HIS A CG 1 ATOM 5298 N ND1 . HIS B 1 281 ? -33.586 -40.835 47.737 1.00 65.07 ? 254 HIS A ND1 1 ATOM 5299 C CD2 . HIS B 1 281 ? -33.466 -40.033 49.774 1.00 63.86 ? 254 HIS A CD2 1 ATOM 5300 C CE1 . HIS B 1 281 ? -34.694 -40.145 47.952 1.00 72.64 ? 254 HIS A CE1 1 ATOM 5301 N NE2 . HIS B 1 281 ? -34.648 -39.653 49.181 1.00 74.49 ? 254 HIS A NE2 1 ATOM 5302 N N . VAL B 1 282 ? -32.251 -44.332 47.830 1.00 53.71 ? 255 VAL A N 1 ATOM 5303 C CA . VAL B 1 282 ? -33.213 -45.153 47.109 1.00 57.47 ? 255 VAL A CA 1 ATOM 5304 C C . VAL B 1 282 ? -33.554 -46.368 47.943 1.00 61.97 ? 255 VAL A C 1 ATOM 5305 O O . VAL B 1 282 ? -34.744 -46.688 48.113 1.00 64.11 ? 255 VAL A O 1 ATOM 5306 C CB . VAL B 1 282 ? -32.701 -45.583 45.723 1.00 58.25 ? 255 VAL A CB 1 ATOM 5307 C CG1 . VAL B 1 282 ? -33.655 -46.572 45.073 1.00 59.54 ? 255 VAL A CG1 1 ATOM 5308 C CG2 . VAL B 1 282 ? -32.584 -44.374 44.828 1.00 55.46 ? 255 VAL A CG2 1 ATOM 5309 N N . VAL B 1 283 ? -32.518 -47.026 48.477 1.00 61.37 ? 256 VAL A N 1 ATOM 5310 C CA . VAL B 1 283 ? -32.713 -48.157 49.400 1.00 58.54 ? 256 VAL A CA 1 ATOM 5311 C C . VAL B 1 283 ? -33.579 -47.756 50.597 1.00 56.35 ? 256 VAL A C 1 ATOM 5312 O O . VAL B 1 283 ? -34.435 -48.524 51.035 1.00 56.87 ? 256 VAL A O 1 ATOM 5313 C CB . VAL B 1 283 ? -31.387 -48.740 49.900 1.00 59.49 ? 256 VAL A CB 1 ATOM 5314 C CG1 . VAL B 1 283 ? -31.622 -49.785 50.973 1.00 60.23 ? 256 VAL A CG1 1 ATOM 5315 C CG2 . VAL B 1 283 ? -30.636 -49.368 48.753 1.00 63.01 ? 256 VAL A CG2 1 ATOM 5316 N N . GLU B 1 284 ? -33.402 -46.552 51.114 1.00 56.89 ? 257 GLU A N 1 ATOM 5317 C CA . GLU B 1 284 ? -34.291 -46.112 52.192 1.00 61.85 ? 257 GLU A CA 1 ATOM 5318 C C . GLU B 1 284 ? -35.736 -45.995 51.732 1.00 63.95 ? 257 GLU A C 1 ATOM 5319 O O . GLU B 1 284 ? -36.612 -46.583 52.362 1.00 58.82 ? 257 GLU A O 1 ATOM 5320 C CB . GLU B 1 284 ? -33.801 -44.832 52.837 1.00 63.26 ? 257 GLU A CB 1 ATOM 5321 C CG . GLU B 1 284 ? -32.630 -45.133 53.763 1.00 70.59 ? 257 GLU A CG 1 ATOM 5322 C CD . GLU B 1 284 ? -32.116 -43.915 54.487 1.00 78.17 ? 257 GLU A CD 1 ATOM 5323 O OE1 . GLU B 1 284 ? -32.853 -42.909 54.525 1.00 84.79 ? 257 GLU A OE1 1 ATOM 5324 O OE2 . GLU B 1 284 ? -30.980 -43.969 55.015 1.00 82.15 ? 257 GLU A OE2 1 ATOM 5325 N N . VAL B 1 285 ? -35.973 -45.309 50.607 1.00 60.26 ? 258 VAL A N 1 ATOM 5326 C CA . VAL B 1 285 ? -37.326 -45.165 50.076 1.00 54.46 ? 258 VAL A CA 1 ATOM 5327 C C . VAL B 1 285 ? -37.973 -46.534 49.934 1.00 57.30 ? 258 VAL A C 1 ATOM 5328 O O . VAL B 1 285 ? -39.129 -46.725 50.316 1.00 61.10 ? 258 VAL A O 1 ATOM 5329 C CB . VAL B 1 285 ? -37.357 -44.448 48.716 1.00 53.08 ? 258 VAL A CB 1 ATOM 5330 C CG1 . VAL B 1 285 ? -38.742 -44.525 48.089 1.00 57.37 ? 258 VAL A CG1 1 ATOM 5331 C CG2 . VAL B 1 285 ? -36.963 -42.985 48.853 1.00 52.82 ? 258 VAL A CG2 1 ATOM 5332 N N . ILE B 1 286 ? -37.226 -47.495 49.412 1.00 57.95 ? 259 ILE A N 1 ATOM 5333 C CA . ILE B 1 286 ? -37.763 -48.853 49.258 1.00 60.70 ? 259 ILE A CA 1 ATOM 5334 C C . ILE B 1 286 ? -38.108 -49.514 50.590 1.00 63.24 ? 259 ILE A C 1 ATOM 5335 O O . ILE B 1 286 ? -39.209 -50.056 50.747 1.00 63.58 ? 259 ILE A O 1 ATOM 5336 C CB . ILE B 1 286 ? -36.789 -49.786 48.530 1.00 57.01 ? 259 ILE A CB 1 ATOM 5337 C CG1 . ILE B 1 286 ? -36.621 -49.360 47.074 1.00 53.93 ? 259 ILE A CG1 1 ATOM 5338 C CG2 . ILE B 1 286 ? -37.301 -51.219 48.590 1.00 57.05 ? 259 ILE A CG2 1 ATOM 5339 C CD1 . ILE B 1 286 ? -35.562 -50.150 46.332 1.00 53.55 ? 259 ILE A CD1 1 ATOM 5340 N N . GLN B 1 287 ? -37.140 -49.498 51.511 1.00 64.58 ? 260 GLN A N 1 ATOM 5341 C CA . GLN B 1 287 ? -37.328 -50.000 52.867 1.00 63.73 ? 260 GLN A CA 1 ATOM 5342 C C . GLN B 1 287 ? -38.535 -49.360 53.560 1.00 65.66 ? 260 GLN A C 1 ATOM 5343 O O . GLN B 1 287 ? -39.401 -50.085 54.044 1.00 66.14 ? 260 GLN A O 1 ATOM 5344 C CB . GLN B 1 287 ? -36.091 -49.749 53.708 1.00 65.75 ? 260 GLN A CB 1 ATOM 5345 C CG . GLN B 1 287 ? -34.963 -50.703 53.440 1.00 69.64 ? 260 GLN A CG 1 ATOM 5346 C CD . GLN B 1 287 ? -33.813 -50.528 54.419 1.00 76.67 ? 260 GLN A CD 1 ATOM 5347 O OE1 . GLN B 1 287 ? -33.426 -49.405 54.759 1.00 69.15 ? 260 GLN A OE1 1 ATOM 5348 N NE2 . GLN B 1 287 ? -33.241 -51.651 54.863 1.00 87.68 ? 260 GLN A NE2 1 ATOM 5349 N N . ASN B 1 288 ? -38.612 -48.020 53.578 1.00 61.28 ? 261 ASN A N 1 ATOM 5350 C CA . ASN B 1 288 ? -39.773 -47.303 54.172 1.00 62.27 ? 261 ASN A CA 1 ATOM 5351 C C . ASN B 1 288 ? -41.133 -47.459 53.434 1.00 62.52 ? 261 ASN A C 1 ATOM 5352 O O . ASN B 1 288 ? -42.107 -46.810 53.811 1.00 72.56 ? 261 ASN A O 1 ATOM 5353 C CB . ASN B 1 288 ? -39.490 -45.798 54.394 1.00 57.28 ? 261 ASN A CB 1 ATOM 5354 C CG . ASN B 1 288 ? -38.226 -45.546 55.194 1.00 68.83 ? 261 ASN A CG 1 ATOM 5355 O OD1 . ASN B 1 288 ? -37.532 -46.485 55.594 1.00 72.32 ? 261 ASN A OD1 1 ATOM 5356 N ND2 . ASN B 1 288 ? -37.904 -44.274 55.421 1.00 78.08 ? 261 ASN A ND2 1 ATOM 5357 N N . SER B 1 289 ? -41.225 -48.319 52.421 1.00 59.56 ? 262 SER A N 1 ATOM 5358 C CA . SER B 1 289 ? -42.471 -48.451 51.649 1.00 55.83 ? 262 SER A CA 1 ATOM 5359 C C . SER B 1 289 ? -43.262 -49.753 51.938 1.00 58.43 ? 262 SER A C 1 ATOM 5360 O O . SER B 1 289 ? -42.701 -50.819 52.198 1.00 63.09 ? 262 SER A O 1 ATOM 5361 C CB . SER B 1 289 ? -42.155 -48.333 50.164 1.00 50.26 ? 262 SER A CB 1 ATOM 5362 O OG . SER B 1 289 ? -43.316 -48.223 49.356 1.00 46.54 ? 262 SER A OG 1 ATOM 5363 N N . THR B 1 290 ? -44.577 -49.638 51.888 1.00 55.23 ? 263 THR A N 1 ATOM 5364 C CA . THR B 1 290 ? -45.446 -50.770 52.022 1.00 59.38 ? 263 THR A CA 1 ATOM 5365 C C . THR B 1 290 ? -45.500 -51.567 50.694 1.00 62.40 ? 263 THR A C 1 ATOM 5366 O O . THR B 1 290 ? -45.991 -52.714 50.660 1.00 56.86 ? 263 THR A O 1 ATOM 5367 C CB . THR B 1 290 ? -46.865 -50.298 52.394 1.00 63.23 ? 263 THR A CB 1 ATOM 5368 O OG1 . THR B 1 290 ? -47.374 -49.442 51.361 1.00 52.87 ? 263 THR A OG1 1 ATOM 5369 C CG2 . THR B 1 290 ? -46.852 -49.551 53.748 1.00 67.72 ? 263 THR A CG2 1 ATOM 5370 N N . ALA B 1 291 ? -45.006 -50.962 49.611 1.00 59.49 ? 264 ALA A N 1 ATOM 5371 C CA . ALA B 1 291 ? -45.045 -51.583 48.281 1.00 62.27 ? 264 ALA A CA 1 ATOM 5372 C C . ALA B 1 291 ? -44.215 -52.871 48.166 1.00 60.69 ? 264 ALA A C 1 ATOM 5373 O O . ALA B 1 291 ? -43.030 -52.874 48.475 1.00 61.33 ? 264 ALA A O 1 ATOM 5374 C CB . ALA B 1 291 ? -44.590 -50.586 47.230 1.00 59.66 ? 264 ALA A CB 1 ATOM 5375 N N . LYS B 1 292 ? -44.864 -53.954 47.736 1.00 57.43 ? 265 LYS A N 1 ATOM 5376 C CA . LYS B 1 292 ? -44.188 -55.218 47.448 1.00 57.61 ? 265 LYS A CA 1 ATOM 5377 C C . LYS B 1 292 ? -43.807 -55.263 45.963 1.00 57.50 ? 265 LYS A C 1 ATOM 5378 O O . LYS B 1 292 ? -42.805 -55.904 45.595 1.00 59.02 ? 265 LYS A O 1 ATOM 5379 C CB . LYS B 1 292 ? -45.080 -56.433 47.809 1.00 52.38 ? 265 LYS A CB 1 ATOM 5380 N N . VAL B 1 293 ? -44.611 -54.615 45.112 1.00 51.40 ? 266 VAL A N 1 ATOM 5381 C CA . VAL B 1 293 ? -44.391 -54.655 43.675 1.00 50.75 ? 266 VAL A CA 1 ATOM 5382 C C . VAL B 1 293 ? -43.556 -53.458 43.192 1.00 52.32 ? 266 VAL A C 1 ATOM 5383 O O . VAL B 1 293 ? -43.956 -52.297 43.332 1.00 47.22 ? 266 VAL A O 1 ATOM 5384 C CB . VAL B 1 293 ? -45.714 -54.699 42.900 1.00 50.33 ? 266 VAL A CB 1 ATOM 5385 C CG1 . VAL B 1 293 ? -45.462 -54.507 41.416 1.00 49.05 ? 266 VAL A CG1 1 ATOM 5386 C CG2 . VAL B 1 293 ? -46.408 -56.041 43.112 1.00 53.85 ? 266 VAL A CG2 1 ATOM 5387 N N . ILE B 1 294 ? -42.402 -53.748 42.595 1.00 54.49 ? 267 ILE A N 1 ATOM 5388 C CA . ILE B 1 294 ? -41.523 -52.689 42.118 1.00 52.86 ? 267 ILE A CA 1 ATOM 5389 C C . ILE B 1 294 ? -41.222 -52.809 40.634 1.00 47.32 ? 267 ILE A C 1 ATOM 5390 O O . ILE B 1 294 ? -40.636 -53.772 40.188 1.00 45.96 ? 267 ILE A O 1 ATOM 5391 C CB . ILE B 1 294 ? -40.234 -52.631 42.946 1.00 54.53 ? 267 ILE A CB 1 ATOM 5392 C CG1 . ILE B 1 294 ? -40.603 -52.659 44.449 1.00 54.22 ? 267 ILE A CG1 1 ATOM 5393 C CG2 . ILE B 1 294 ? -39.443 -51.371 42.575 1.00 52.46 ? 267 ILE A CG2 1 ATOM 5394 C CD1 . ILE B 1 294 ? -39.481 -52.283 45.387 1.00 55.73 ? 267 ILE A CD1 1 ATOM 5395 N N . VAL B 1 295 ? -41.646 -51.803 39.885 1.00 45.73 ? 268 VAL A N 1 ATOM 5396 C CA . VAL B 1 295 ? -41.388 -51.728 38.459 1.00 48.17 ? 268 VAL A CA 1 ATOM 5397 C C . VAL B 1 295 ? -40.080 -51.021 38.181 1.00 49.91 ? 268 VAL A C 1 ATOM 5398 O O . VAL B 1 295 ? -39.920 -49.846 38.531 1.00 47.31 ? 268 VAL A O 1 ATOM 5399 C CB . VAL B 1 295 ? -42.477 -50.921 37.750 1.00 45.54 ? 268 VAL A CB 1 ATOM 5400 C CG1 . VAL B 1 295 ? -42.237 -50.906 36.253 1.00 42.64 ? 268 VAL A CG1 1 ATOM 5401 C CG2 . VAL B 1 295 ? -43.811 -51.554 38.049 1.00 48.42 ? 268 VAL A CG2 1 ATOM 5402 N N . VAL B 1 296 ? -39.178 -51.728 37.504 1.00 52.19 ? 269 VAL A N 1 ATOM 5403 C CA . VAL B 1 296 ? -37.829 -51.245 37.227 1.00 50.44 ? 269 VAL A CA 1 ATOM 5404 C C . VAL B 1 296 ? -37.461 -51.205 35.744 1.00 49.50 ? 269 VAL A C 1 ATOM 5405 O O . VAL B 1 296 ? -37.267 -52.234 35.076 1.00 44.31 ? 269 VAL A O 1 ATOM 5406 C CB . VAL B 1 296 ? -36.826 -52.128 37.952 1.00 52.78 ? 269 VAL A CB 1 ATOM 5407 C CG1 . VAL B 1 296 ? -35.420 -51.587 37.749 1.00 54.88 ? 269 VAL A CG1 1 ATOM 5408 C CG2 . VAL B 1 296 ? -37.201 -52.203 39.442 1.00 52.42 ? 269 VAL A CG2 1 ATOM 5409 N N . PHE B 1 297 ? -37.316 -49.995 35.245 1.00 52.27 ? 270 PHE A N 1 ATOM 5410 C CA . PHE B 1 297 ? -36.980 -49.789 33.836 1.00 54.00 ? 270 PHE A CA 1 ATOM 5411 C C . PHE B 1 297 ? -35.539 -49.355 33.710 1.00 52.61 ? 270 PHE A C 1 ATOM 5412 O O . PHE B 1 297 ? -35.226 -48.177 33.872 1.00 47.49 ? 270 PHE A O 1 ATOM 5413 C CB . PHE B 1 297 ? -37.880 -48.720 33.251 1.00 56.29 ? 270 PHE A CB 1 ATOM 5414 C CG . PHE B 1 297 ? -38.524 -49.130 31.994 1.00 58.65 ? 270 PHE A CG 1 ATOM 5415 C CD1 . PHE B 1 297 ? -37.804 -49.129 30.807 1.00 59.27 ? 270 PHE A CD1 1 ATOM 5416 C CD2 . PHE B 1 297 ? -39.844 -49.561 31.990 1.00 56.20 ? 270 PHE A CD2 1 ATOM 5417 C CE1 . PHE B 1 297 ? -38.405 -49.520 29.620 1.00 53.82 ? 270 PHE A CE1 1 ATOM 5418 C CE2 . PHE B 1 297 ? -40.435 -49.971 30.810 1.00 56.28 ? 270 PHE A CE2 1 ATOM 5419 C CZ . PHE B 1 297 ? -39.717 -49.936 29.621 1.00 52.30 ? 270 PHE A CZ 1 ATOM 5420 N N . SER B 1 298 ? -34.649 -50.307 33.448 1.00 55.00 ? 271 SER A N 1 ATOM 5421 C CA . SER B 1 298 ? -33.227 -49.999 33.440 1.00 51.75 ? 271 SER A CA 1 ATOM 5422 C C . SER B 1 298 ? -32.427 -51.041 32.741 1.00 49.48 ? 271 SER A C 1 ATOM 5423 O O . SER B 1 298 ? -32.888 -52.133 32.532 1.00 51.30 ? 271 SER A O 1 ATOM 5424 C CB . SER B 1 298 ? -32.700 -49.888 34.879 1.00 53.40 ? 271 SER A CB 1 ATOM 5425 O OG . SER B 1 298 ? -31.278 -49.716 34.905 1.00 52.70 ? 271 SER A OG 1 ATOM 5426 N N . SER B 1 299 ? -31.206 -50.672 32.388 1.00 55.28 ? 272 SER A N 1 ATOM 5427 C CA . SER B 1 299 ? -30.181 -51.618 31.961 1.00 51.70 ? 272 SER A CA 1 ATOM 5428 C C . SER B 1 299 ? -29.551 -52.207 33.209 1.00 50.68 ? 272 SER A C 1 ATOM 5429 O O . SER B 1 299 ? -29.643 -51.636 34.310 1.00 47.70 ? 272 SER A O 1 ATOM 5430 C CB . SER B 1 299 ? -29.092 -50.917 31.134 1.00 48.55 ? 272 SER A CB 1 ATOM 5431 O OG . SER B 1 299 ? -28.154 -50.228 31.976 1.00 48.26 ? 272 SER A OG 1 ATOM 5432 N N . GLY B 1 300 ? -28.901 -53.351 33.023 1.00 51.43 ? 273 GLY A N 1 ATOM 5433 C CA . GLY B 1 300 ? -28.222 -54.047 34.110 1.00 46.67 ? 273 GLY A CA 1 ATOM 5434 C C . GLY B 1 300 ? -27.204 -53.132 34.738 1.00 47.71 ? 273 GLY A C 1 ATOM 5435 O O . GLY B 1 300 ? -27.207 -52.939 35.957 1.00 46.33 ? 273 GLY A O 1 ATOM 5436 N N . PRO B 1 301 ? -26.329 -52.548 33.908 1.00 48.95 ? 274 PRO A N 1 ATOM 5437 C CA . PRO B 1 301 ? -25.233 -51.743 34.462 1.00 49.26 ? 274 PRO A CA 1 ATOM 5438 C C . PRO B 1 301 ? -25.662 -50.551 35.307 1.00 55.38 ? 274 PRO A C 1 ATOM 5439 O O . PRO B 1 301 ? -24.978 -50.236 36.265 1.00 63.75 ? 274 PRO A O 1 ATOM 5440 C CB . PRO B 1 301 ? -24.478 -51.293 33.230 1.00 47.59 ? 274 PRO A CB 1 ATOM 5441 C CG . PRO B 1 301 ? -24.719 -52.395 32.245 1.00 50.18 ? 274 PRO A CG 1 ATOM 5442 C CD . PRO B 1 301 ? -26.085 -52.937 32.507 1.00 46.33 ? 274 PRO A CD 1 ATOM 5443 N N . ASP B 1 302 ? -26.781 -49.908 34.976 1.00 59.46 ? 275 ASP A N 1 ATOM 5444 C CA . ASP B 1 302 ? -27.301 -48.792 35.788 1.00 59.05 ? 275 ASP A CA 1 ATOM 5445 C C . ASP B 1 302 ? -28.023 -49.270 37.044 1.00 56.52 ? 275 ASP A C 1 ATOM 5446 O O . ASP B 1 302 ? -28.155 -48.538 38.007 1.00 53.21 ? 275 ASP A O 1 ATOM 5447 C CB . ASP B 1 302 ? -28.275 -47.938 34.966 1.00 61.70 ? 275 ASP A CB 1 ATOM 5448 C CG . ASP B 1 302 ? -27.601 -47.193 33.821 1.00 62.86 ? 275 ASP A CG 1 ATOM 5449 O OD1 . ASP B 1 302 ? -26.562 -46.527 34.059 1.00 67.37 ? 275 ASP A OD1 1 ATOM 5450 O OD2 . ASP B 1 302 ? -28.141 -47.250 32.686 1.00 65.08 ? 275 ASP A OD2 1 ATOM 5451 N N . LEU B 1 303 ? -28.522 -50.495 37.001 1.00 58.31 ? 276 LEU A N 1 ATOM 5452 C CA . LEU B 1 303 ? -29.230 -51.099 38.117 1.00 58.73 ? 276 LEU A CA 1 ATOM 5453 C C . LEU B 1 303 ? -28.291 -51.729 39.157 1.00 58.82 ? 276 LEU A C 1 ATOM 5454 O O . LEU B 1 303 ? -28.618 -51.790 40.338 1.00 56.21 ? 276 LEU A O 1 ATOM 5455 C CB . LEU B 1 303 ? -30.173 -52.192 37.565 1.00 59.96 ? 276 LEU A CB 1 ATOM 5456 C CG . LEU B 1 303 ? -31.156 -52.883 38.524 1.00 55.85 ? 276 LEU A CG 1 ATOM 5457 C CD1 . LEU B 1 303 ? -32.008 -51.829 39.209 1.00 62.51 ? 276 LEU A CD1 1 ATOM 5458 C CD2 . LEU B 1 303 ? -32.038 -53.870 37.786 1.00 52.69 ? 276 LEU A CD2 1 ATOM 5459 N N . GLU B 1 304 ? -27.133 -52.211 38.713 1.00 63.39 ? 277 GLU A N 1 ATOM 5460 C CA . GLU B 1 304 ? -26.355 -53.160 39.504 1.00 68.30 ? 277 GLU A CA 1 ATOM 5461 C C . GLU B 1 304 ? -25.928 -52.581 40.842 1.00 65.53 ? 277 GLU A C 1 ATOM 5462 O O . GLU B 1 304 ? -26.003 -53.263 41.860 1.00 70.67 ? 277 GLU A O 1 ATOM 5463 C CB . GLU B 1 304 ? -25.157 -53.690 38.711 1.00 72.33 ? 277 GLU A CB 1 ATOM 5464 C CG . GLU B 1 304 ? -24.089 -54.328 39.571 1.00 81.87 ? 277 GLU A CG 1 ATOM 5465 C CD . GLU B 1 304 ? -22.932 -54.876 38.762 1.00 96.28 ? 277 GLU A CD 1 ATOM 5466 O OE1 . GLU B 1 304 ? -22.287 -54.085 38.025 1.00 97.48 ? 277 GLU A OE1 1 ATOM 5467 O OE2 . GLU B 1 304 ? -22.655 -56.097 38.886 1.00 101.63 ? 277 GLU A OE2 1 ATOM 5468 N N . PRO B 1 305 ? -25.492 -51.321 40.850 1.00 61.26 ? 278 PRO A N 1 ATOM 5469 C CA . PRO B 1 305 ? -25.157 -50.715 42.136 1.00 63.49 ? 278 PRO A CA 1 ATOM 5470 C C . PRO B 1 305 ? -26.313 -50.758 43.125 1.00 62.34 ? 278 PRO A C 1 ATOM 5471 O O . PRO B 1 305 ? -26.093 -51.058 44.291 1.00 67.06 ? 278 PRO A O 1 ATOM 5472 C CB . PRO B 1 305 ? -24.794 -49.260 41.768 1.00 62.82 ? 278 PRO A CB 1 ATOM 5473 C CG . PRO B 1 305 ? -24.318 -49.344 40.354 1.00 59.99 ? 278 PRO A CG 1 ATOM 5474 C CD . PRO B 1 305 ? -25.107 -50.462 39.711 1.00 62.10 ? 278 PRO A CD 1 ATOM 5475 N N . LEU B 1 306 ? -27.528 -50.469 42.668 1.00 59.61 ? 279 LEU A N 1 ATOM 5476 C CA . LEU B 1 306 ? -28.694 -50.567 43.550 1.00 62.04 ? 279 LEU A CA 1 ATOM 5477 C C . LEU B 1 306 ? -28.886 -52.013 44.101 1.00 59.86 ? 279 LEU A C 1 ATOM 5478 O O . LEU B 1 306 ? -28.961 -52.222 45.325 1.00 52.68 ? 279 LEU A O 1 ATOM 5479 C CB . LEU B 1 306 ? -29.948 -50.057 42.840 1.00 57.77 ? 279 LEU A CB 1 ATOM 5480 C CG . LEU B 1 306 ? -31.248 -50.115 43.640 1.00 61.38 ? 279 LEU A CG 1 ATOM 5481 C CD1 . LEU B 1 306 ? -31.275 -49.174 44.839 1.00 61.21 ? 279 LEU A CD1 1 ATOM 5482 C CD2 . LEU B 1 306 ? -32.397 -49.821 42.699 1.00 64.95 ? 279 LEU A CD2 1 ATOM 5483 N N . ILE B 1 307 ? -28.923 -53.002 43.214 1.00 52.34 ? 280 ILE A N 1 ATOM 5484 C CA . ILE B 1 307 ? -29.110 -54.360 43.670 1.00 59.44 ? 280 ILE A CA 1 ATOM 5485 C C . ILE B 1 307 ? -28.055 -54.780 44.738 1.00 64.61 ? 280 ILE A C 1 ATOM 5486 O O . ILE B 1 307 ? -28.396 -55.380 45.762 1.00 74.54 ? 280 ILE A O 1 ATOM 5487 C CB . ILE B 1 307 ? -29.170 -55.334 42.484 1.00 60.14 ? 280 ILE A CB 1 ATOM 5488 C CG1 . ILE B 1 307 ? -30.452 -55.116 41.671 1.00 67.77 ? 280 ILE A CG1 1 ATOM 5489 C CG2 . ILE B 1 307 ? -29.140 -56.781 42.941 1.00 58.42 ? 280 ILE A CG2 1 ATOM 5490 C CD1 . ILE B 1 307 ? -31.754 -55.498 42.377 1.00 71.53 ? 280 ILE A CD1 1 ATOM 5491 N N . LYS B 1 308 ? -26.795 -54.440 44.530 1.00 59.06 ? 281 LYS A N 1 ATOM 5492 C CA . LYS B 1 308 ? -25.769 -54.797 45.496 1.00 55.71 ? 281 LYS A CA 1 ATOM 5493 C C . LYS B 1 308 ? -26.134 -54.319 46.869 1.00 53.36 ? 281 LYS A C 1 ATOM 5494 O O . LYS B 1 308 ? -26.047 -55.074 47.828 1.00 58.28 ? 281 LYS A O 1 ATOM 5495 C CB . LYS B 1 308 ? -24.386 -54.241 45.106 1.00 52.79 ? 281 LYS A CB 1 ATOM 5496 C CG . LYS B 1 308 ? -23.748 -55.079 44.011 1.00 53.03 ? 281 LYS A CG 1 ATOM 5497 C CD . LYS B 1 308 ? -22.468 -54.454 43.552 1.00 56.94 ? 281 LYS A CD 1 ATOM 5498 C CE . LYS B 1 308 ? -21.776 -55.370 42.554 1.00 63.94 ? 281 LYS A CE 1 ATOM 5499 N NZ . LYS B 1 308 ? -20.509 -54.794 41.988 1.00 69.34 ? 281 LYS A NZ 1 ATOM 5500 N N . GLU B 1 309 ? -26.557 -53.072 46.978 1.00 54.41 ? 282 GLU A N 1 ATOM 5501 C CA . GLU B 1 309 ? -26.831 -52.513 48.295 1.00 55.19 ? 282 GLU A CA 1 ATOM 5502 C C . GLU B 1 309 ? -28.099 -53.116 48.887 1.00 55.19 ? 282 GLU A C 1 ATOM 5503 O O . GLU B 1 309 ? -28.236 -53.155 50.093 1.00 59.03 ? 282 GLU A O 1 ATOM 5504 C CB . GLU B 1 309 ? -26.930 -51.004 48.231 1.00 56.22 ? 282 GLU A CB 1 ATOM 5505 C CG . GLU B 1 309 ? -27.118 -50.318 49.577 1.00 66.09 ? 282 GLU A CG 1 ATOM 5506 C CD . GLU B 1 309 ? -25.953 -50.480 50.543 1.00 72.71 ? 282 GLU A CD 1 ATOM 5507 O OE1 . GLU B 1 309 ? -26.147 -50.178 51.748 1.00 75.08 ? 282 GLU A OE1 1 ATOM 5508 O OE2 . GLU B 1 309 ? -24.850 -50.885 50.110 1.00 79.60 ? 282 GLU A OE2 1 ATOM 5509 N N . ILE B 1 310 ? -28.997 -53.609 48.038 1.00 54.99 ? 283 ILE A N 1 ATOM 5510 C CA . ILE B 1 310 ? -30.273 -54.152 48.481 1.00 58.62 ? 283 ILE A CA 1 ATOM 5511 C C . ILE B 1 310 ? -30.067 -55.560 49.029 1.00 60.25 ? 283 ILE A C 1 ATOM 5512 O O . ILE B 1 310 ? -30.639 -55.952 50.054 1.00 55.66 ? 283 ILE A O 1 ATOM 5513 C CB . ILE B 1 310 ? -31.299 -54.156 47.322 1.00 60.48 ? 283 ILE A CB 1 ATOM 5514 C CG1 . ILE B 1 310 ? -31.842 -52.731 47.133 1.00 69.59 ? 283 ILE A CG1 1 ATOM 5515 C CG2 . ILE B 1 310 ? -32.472 -55.096 47.607 1.00 58.22 ? 283 ILE A CG2 1 ATOM 5516 C CD1 . ILE B 1 310 ? -32.724 -52.535 45.906 1.00 72.35 ? 283 ILE A CD1 1 ATOM 5517 N N . VAL B 1 311 ? -29.278 -56.323 48.294 1.00 58.81 ? 284 VAL A N 1 ATOM 5518 C CA . VAL B 1 311 ? -28.808 -57.595 48.740 1.00 56.29 ? 284 VAL A CA 1 ATOM 5519 C C . VAL B 1 311 ? -28.028 -57.395 50.037 1.00 62.63 ? 284 VAL A C 1 ATOM 5520 O O . VAL B 1 311 ? -28.212 -58.142 51.008 1.00 62.62 ? 284 VAL A O 1 ATOM 5521 C CB . VAL B 1 311 ? -27.924 -58.199 47.660 1.00 58.10 ? 284 VAL A CB 1 ATOM 5522 C CG1 . VAL B 1 311 ? -27.119 -59.382 48.193 1.00 56.29 ? 284 VAL A CG1 1 ATOM 5523 C CG2 . VAL B 1 311 ? -28.807 -58.601 46.488 1.00 59.78 ? 284 VAL A CG2 1 ATOM 5524 N N . ARG B 1 312 ? -27.179 -56.372 50.080 1.00 61.95 ? 285 ARG A N 1 ATOM 5525 C CA . ARG B 1 312 ? -26.432 -56.116 51.304 1.00 65.97 ? 285 ARG A CA 1 ATOM 5526 C C . ARG B 1 312 ? -27.395 -56.022 52.502 1.00 67.69 ? 285 ARG A C 1 ATOM 5527 O O . ARG B 1 312 ? -27.167 -56.664 53.515 1.00 68.17 ? 285 ARG A O 1 ATOM 5528 C CB . ARG B 1 312 ? -25.579 -54.854 51.195 1.00 68.37 ? 285 ARG A CB 1 ATOM 5529 C CG . ARG B 1 312 ? -24.148 -55.039 51.666 1.00 73.50 ? 285 ARG A CG 1 ATOM 5530 C CD . ARG B 1 312 ? -23.539 -53.709 52.055 1.00 83.50 ? 285 ARG A CD 1 ATOM 5531 N NE . ARG B 1 312 ? -24.179 -53.198 53.273 1.00 93.18 ? 285 ARG A NE 1 ATOM 5532 C CZ . ARG B 1 312 ? -24.254 -51.913 53.632 1.00 99.77 ? 285 ARG A CZ 1 ATOM 5533 N NH1 . ARG B 1 312 ? -24.870 -51.593 54.767 1.00 95.91 ? 285 ARG A NH1 1 ATOM 5534 N NH2 . ARG B 1 312 ? -23.728 -50.945 52.872 1.00 104.10 ? 285 ARG A NH2 1 ATOM 5535 N N . ARG B 1 313 ? -28.481 -55.261 52.367 1.00 64.42 ? 286 ARG A N 1 ATOM 5536 C CA . ARG B 1 313 ? -29.411 -55.033 53.475 1.00 65.01 ? 286 ARG A CA 1 ATOM 5537 C C . ARG B 1 313 ? -30.535 -56.070 53.530 1.00 68.76 ? 286 ARG A C 1 ATOM 5538 O O . ARG B 1 313 ? -31.517 -55.909 54.275 1.00 67.65 ? 286 ARG A O 1 ATOM 5539 C CB . ARG B 1 313 ? -29.999 -53.624 53.406 1.00 63.86 ? 286 ARG A CB 1 ATOM 5540 C CG . ARG B 1 313 ? -28.938 -52.552 53.395 1.00 69.18 ? 286 ARG A CG 1 ATOM 5541 C CD . ARG B 1 313 ? -29.545 -51.236 53.809 1.00 76.41 ? 286 ARG A CD 1 ATOM 5542 N NE . ARG B 1 313 ? -28.716 -50.072 53.506 1.00 78.20 ? 286 ARG A NE 1 ATOM 5543 C CZ . ARG B 1 313 ? -29.028 -48.830 53.877 1.00 87.07 ? 286 ARG A CZ 1 ATOM 5544 N NH1 . ARG B 1 313 ? -30.141 -48.592 54.570 1.00 84.20 ? 286 ARG A NH1 1 ATOM 5545 N NH2 . ARG B 1 313 ? -28.231 -47.815 53.554 1.00 95.10 ? 286 ARG A NH2 1 ATOM 5546 N N . ASN B 1 314 ? -30.406 -57.131 52.743 1.00 65.91 ? 287 ASN A N 1 ATOM 5547 C CA . ASN B 1 314 ? -31.296 -58.263 52.879 1.00 70.51 ? 287 ASN A CA 1 ATOM 5548 C C . ASN B 1 314 ? -32.774 -57.940 52.643 1.00 76.31 ? 287 ASN A C 1 ATOM 5549 O O . ASN B 1 314 ? -33.646 -58.508 53.309 1.00 79.06 ? 287 ASN A O 1 ATOM 5550 C CB . ASN B 1 314 ? -31.138 -58.805 54.282 1.00 72.73 ? 287 ASN A CB 1 ATOM 5551 C CG . ASN B 1 314 ? -31.519 -60.244 54.396 1.00 79.42 ? 287 ASN A CG 1 ATOM 5552 O OD1 . ASN B 1 314 ? -31.495 -60.999 53.401 1.00 65.74 ? 287 ASN A OD1 1 ATOM 5553 N ND2 . ASN B 1 314 ? -31.882 -60.649 55.635 1.00 92.77 ? 287 ASN A ND2 1 ATOM 5554 N N . ILE B 1 315 ? -33.065 -57.043 51.700 1.00 72.99 ? 288 ILE A N 1 ATOM 5555 C CA . ILE B 1 315 ? -34.445 -56.646 51.457 1.00 70.29 ? 288 ILE A CA 1 ATOM 5556 C C . ILE B 1 315 ? -35.184 -57.667 50.588 1.00 73.45 ? 288 ILE A C 1 ATOM 5557 O O . ILE B 1 315 ? -34.884 -57.858 49.408 1.00 69.78 ? 288 ILE A O 1 ATOM 5558 C CB . ILE B 1 315 ? -34.554 -55.239 50.875 1.00 68.92 ? 288 ILE A CB 1 ATOM 5559 C CG1 . ILE B 1 315 ? -33.953 -54.243 51.859 1.00 73.76 ? 288 ILE A CG1 1 ATOM 5560 C CG2 . ILE B 1 315 ? -36.015 -54.898 50.621 1.00 66.74 ? 288 ILE A CG2 1 ATOM 5561 C CD1 . ILE B 1 315 ? -33.750 -52.853 51.300 1.00 76.06 ? 288 ILE A CD1 1 ATOM 5562 N N . THR B 1 316 ? -36.222 -58.240 51.193 1.00 77.14 ? 289 THR A N 1 ATOM 5563 C CA . THR B 1 316 ? -36.749 -59.534 50.821 1.00 76.11 ? 289 THR A CA 1 ATOM 5564 C C . THR B 1 316 ? -38.201 -59.482 50.404 1.00 67.16 ? 289 THR A C 1 ATOM 5565 O O . THR B 1 316 ? -38.952 -58.571 50.752 1.00 65.88 ? 289 THR A O 1 ATOM 5566 C CB . THR B 1 316 ? -36.505 -60.518 52.008 1.00 85.72 ? 289 THR A CB 1 ATOM 5567 O OG1 . THR B 1 316 ? -35.468 -61.421 51.632 1.00 92.09 ? 289 THR A OG1 1 ATOM 5568 C CG2 . THR B 1 316 ? -37.756 -61.332 52.462 1.00 84.48 ? 289 THR A CG2 1 ATOM 5569 N N . GLY B 1 317 ? -38.586 -60.489 49.646 1.00 67.08 ? 290 GLY A N 1 ATOM 5570 C CA . GLY B 1 317 ? -39.974 -60.671 49.258 1.00 68.03 ? 290 GLY A CA 1 ATOM 5571 C C . GLY B 1 317 ? -40.556 -59.560 48.409 1.00 70.82 ? 290 GLY A C 1 ATOM 5572 O O . GLY B 1 317 ? -41.755 -59.294 48.488 1.00 68.00 ? 290 GLY A O 1 ATOM 5573 N N . LYS B 1 318 ? -39.730 -58.901 47.596 1.00 69.64 ? 291 LYS A N 1 ATOM 5574 C CA . LYS B 1 318 ? -40.265 -57.926 46.651 1.00 63.86 ? 291 LYS A CA 1 ATOM 5575 C C . LYS B 1 318 ? -40.588 -58.607 45.358 1.00 56.20 ? 291 LYS A C 1 ATOM 5576 O O . LYS B 1 318 ? -39.960 -59.586 44.984 1.00 54.75 ? 291 LYS A O 1 ATOM 5577 C CB . LYS B 1 318 ? -39.292 -56.784 46.400 1.00 63.71 ? 291 LYS A CB 1 ATOM 5578 C CG . LYS B 1 318 ? -38.985 -55.969 47.642 1.00 60.87 ? 291 LYS A CG 1 ATOM 5579 C CD . LYS B 1 318 ? -40.170 -55.158 48.144 1.00 57.59 ? 291 LYS A CD 1 ATOM 5580 C CE . LYS B 1 318 ? -39.752 -54.439 49.417 1.00 56.53 ? 291 LYS A CE 1 ATOM 5581 N NZ . LYS B 1 318 ? -40.879 -53.803 50.138 1.00 55.03 ? 291 LYS A NZ 1 ATOM 5582 N N . ILE B 1 319 ? -41.588 -58.093 44.670 1.00 56.49 ? 292 ILE A N 1 ATOM 5583 C CA . ILE B 1 319 ? -41.890 -58.589 43.346 1.00 54.25 ? 292 ILE A CA 1 ATOM 5584 C C . ILE B 1 319 ? -41.387 -57.566 42.347 1.00 57.93 ? 292 ILE A C 1 ATOM 5585 O O . ILE B 1 319 ? -41.909 -56.450 42.259 1.00 62.77 ? 292 ILE A O 1 ATOM 5586 C CB . ILE B 1 319 ? -43.380 -58.853 43.149 1.00 53.73 ? 292 ILE A CB 1 ATOM 5587 C CG1 . ILE B 1 319 ? -43.924 -59.751 44.285 1.00 51.73 ? 292 ILE A CG1 1 ATOM 5588 C CG2 . ILE B 1 319 ? -43.589 -59.486 41.783 1.00 54.98 ? 292 ILE A CG2 1 ATOM 5589 C CD1 . ILE B 1 319 ? -45.375 -60.171 44.147 1.00 49.92 ? 292 ILE A CD1 1 ATOM 5590 N N . TRP B 1 320 ? -40.356 -57.974 41.611 1.00 59.95 ? 293 TRP A N 1 ATOM 5591 C CA . TRP B 1 320 ? -39.663 -57.145 40.637 1.00 59.00 ? 293 TRP A CA 1 ATOM 5592 C C . TRP B 1 320 ? -40.274 -57.359 39.257 1.00 58.65 ? 293 TRP A C 1 ATOM 5593 O O . TRP B 1 320 ? -40.332 -58.479 38.751 1.00 63.27 ? 293 TRP A O 1 ATOM 5594 C CB . TRP B 1 320 ? -38.161 -57.491 40.618 1.00 57.72 ? 293 TRP A CB 1 ATOM 5595 C CG . TRP B 1 320 ? -37.494 -57.357 41.968 1.00 59.16 ? 293 TRP A CG 1 ATOM 5596 C CD1 . TRP B 1 320 ? -37.226 -58.357 42.846 1.00 63.89 ? 293 TRP A CD1 1 ATOM 5597 C CD2 . TRP B 1 320 ? -37.047 -56.154 42.593 1.00 60.41 ? 293 TRP A CD2 1 ATOM 5598 N NE1 . TRP B 1 320 ? -36.638 -57.858 43.980 1.00 62.18 ? 293 TRP A NE1 1 ATOM 5599 C CE2 . TRP B 1 320 ? -36.514 -56.508 43.854 1.00 61.50 ? 293 TRP A CE2 1 ATOM 5600 C CE3 . TRP B 1 320 ? -37.044 -54.811 42.214 1.00 59.02 ? 293 TRP A CE3 1 ATOM 5601 C CZ2 . TRP B 1 320 ? -35.982 -55.574 44.736 1.00 64.44 ? 293 TRP A CZ2 1 ATOM 5602 C CZ3 . TRP B 1 320 ? -36.513 -53.873 43.103 1.00 62.07 ? 293 TRP A CZ3 1 ATOM 5603 C CH2 . TRP B 1 320 ? -35.996 -54.261 44.347 1.00 65.11 ? 293 TRP A CH2 1 ATOM 5604 N N . LEU B 1 321 ? -40.755 -56.280 38.663 1.00 55.98 ? 294 LEU A N 1 ATOM 5605 C CA . LEU B 1 321 ? -41.141 -56.288 37.271 1.00 54.43 ? 294 LEU A CA 1 ATOM 5606 C C . LEU B 1 321 ? -39.987 -55.677 36.461 1.00 56.86 ? 294 LEU A C 1 ATOM 5607 O O . LEU B 1 321 ? -39.625 -54.504 36.622 1.00 50.57 ? 294 LEU A O 1 ATOM 5608 C CB . LEU B 1 321 ? -42.431 -55.508 37.080 1.00 58.96 ? 294 LEU A CB 1 ATOM 5609 C CG . LEU B 1 321 ? -43.739 -56.311 37.016 1.00 65.15 ? 294 LEU A CG 1 ATOM 5610 C CD1 . LEU B 1 321 ? -43.764 -57.492 37.979 1.00 71.43 ? 294 LEU A CD1 1 ATOM 5611 C CD2 . LEU B 1 321 ? -44.916 -55.393 37.300 1.00 61.53 ? 294 LEU A CD2 1 ATOM 5612 N N . ALA B 1 322 ? -39.427 -56.490 35.574 1.00 56.45 ? 295 ALA A N 1 ATOM 5613 C CA . ALA B 1 322 ? -38.179 -56.178 34.925 1.00 51.71 ? 295 ALA A CA 1 ATOM 5614 C C . ALA B 1 322 ? -38.416 -55.797 33.502 1.00 52.56 ? 295 ALA A C 1 ATOM 5615 O O . ALA B 1 322 ? -39.019 -56.577 32.769 1.00 48.85 ? 295 ALA A O 1 ATOM 5616 C CB . ALA B 1 322 ? -37.287 -57.380 34.961 1.00 54.27 ? 295 ALA A CB 1 ATOM 5617 N N . SER B 1 323 ? -37.940 -54.604 33.115 1.00 49.71 ? 296 SER A N 1 ATOM 5618 C CA . SER B 1 323 ? -37.887 -54.215 31.709 1.00 47.40 ? 296 SER A CA 1 ATOM 5619 C C . SER B 1 323 ? -36.855 -55.097 31.036 1.00 47.84 ? 296 SER A C 1 ATOM 5620 O O . SER B 1 323 ? -35.993 -55.661 31.687 1.00 49.15 ? 296 SER A O 1 ATOM 5621 C CB . SER B 1 323 ? -37.492 -52.739 31.534 1.00 47.92 ? 296 SER A CB 1 ATOM 5622 O OG . SER B 1 323 ? -36.090 -52.513 31.762 1.00 49.52 ? 296 SER A OG 1 ATOM 5623 N N . GLU B 1 324 ? -36.903 -55.156 29.721 1.00 54.58 ? 297 GLU A N 1 ATOM 5624 C CA . GLU B 1 324 ? -36.203 -56.183 28.942 1.00 58.19 ? 297 GLU A CA 1 ATOM 5625 C C . GLU B 1 324 ? -34.698 -56.001 28.982 1.00 53.74 ? 297 GLU A C 1 ATOM 5626 O O . GLU B 1 324 ? -33.967 -56.953 28.866 1.00 54.56 ? 297 GLU A O 1 ATOM 5627 C CB . GLU B 1 324 ? -36.770 -56.225 27.517 1.00 58.19 ? 297 GLU A CB 1 ATOM 5628 C CG . GLU B 1 324 ? -35.954 -57.007 26.530 1.00 72.47 ? 297 GLU A CG 1 ATOM 5629 C CD . GLU B 1 324 ? -34.757 -56.230 26.037 1.00 87.00 ? 297 GLU A CD 1 ATOM 5630 O OE1 . GLU B 1 324 ? -34.876 -54.982 25.890 1.00 102.45 ? 297 GLU A OE1 1 ATOM 5631 O OE2 . GLU B 1 324 ? -33.704 -56.878 25.805 1.00 90.54 ? 297 GLU A OE2 1 ATOM 5632 N N . ALA B 1 325 ? -34.250 -54.779 29.213 1.00 58.01 ? 298 ALA A N 1 ATOM 5633 C CA . ALA B 1 325 ? -32.831 -54.472 29.290 1.00 57.16 ? 298 ALA A CA 1 ATOM 5634 C C . ALA B 1 325 ? -32.101 -55.155 30.442 1.00 59.26 ? 298 ALA A C 1 ATOM 5635 O O . ALA B 1 325 ? -30.875 -55.286 30.388 1.00 70.81 ? 298 ALA A O 1 ATOM 5636 C CB . ALA B 1 325 ? -32.652 -52.971 29.405 1.00 56.98 ? 298 ALA A CB 1 ATOM 5637 N N . TRP B 1 326 ? -32.821 -55.533 31.500 1.00 55.05 ? 299 TRP A N 1 ATOM 5638 C CA . TRP B 1 326 ? -32.212 -56.287 32.613 1.00 52.95 ? 299 TRP A CA 1 ATOM 5639 C C . TRP B 1 326 ? -32.872 -57.625 32.937 1.00 50.71 ? 299 TRP A C 1 ATOM 5640 O O . TRP B 1 326 ? -32.315 -58.412 33.678 1.00 47.46 ? 299 TRP A O 1 ATOM 5641 C CB . TRP B 1 326 ? -32.101 -55.437 33.883 1.00 51.63 ? 299 TRP A CB 1 ATOM 5642 C CG . TRP B 1 326 ? -33.367 -55.210 34.696 1.00 51.89 ? 299 TRP A CG 1 ATOM 5643 C CD1 . TRP B 1 326 ? -34.297 -54.236 34.508 1.00 51.50 ? 299 TRP A CD1 1 ATOM 5644 C CD2 . TRP B 1 326 ? -33.777 -55.928 35.857 1.00 52.97 ? 299 TRP A CD2 1 ATOM 5645 N NE1 . TRP B 1 326 ? -35.259 -54.307 35.471 1.00 54.06 ? 299 TRP A NE1 1 ATOM 5646 C CE2 . TRP B 1 326 ? -34.962 -55.349 36.310 1.00 54.64 ? 299 TRP A CE2 1 ATOM 5647 C CE3 . TRP B 1 326 ? -33.259 -57.011 36.553 1.00 58.95 ? 299 TRP A CE3 1 ATOM 5648 C CZ2 . TRP B 1 326 ? -35.638 -55.824 37.433 1.00 53.10 ? 299 TRP A CZ2 1 ATOM 5649 C CZ3 . TRP B 1 326 ? -33.934 -57.473 37.681 1.00 55.03 ? 299 TRP A CZ3 1 ATOM 5650 C CH2 . TRP B 1 326 ? -35.098 -56.882 38.101 1.00 52.38 ? 299 TRP A CH2 1 ATOM 5651 N N . ALA B 1 327 ? -34.029 -57.888 32.349 1.00 50.21 ? 300 ALA A N 1 ATOM 5652 C CA . ALA B 1 327 ? -34.769 -59.113 32.596 1.00 51.35 ? 300 ALA A CA 1 ATOM 5653 C C . ALA B 1 327 ? -33.956 -60.375 32.277 1.00 55.58 ? 300 ALA A C 1 ATOM 5654 O O . ALA B 1 327 ? -34.284 -61.445 32.782 1.00 55.13 ? 300 ALA A O 1 ATOM 5655 C CB . ALA B 1 327 ? -36.041 -59.092 31.774 1.00 48.72 ? 300 ALA A CB 1 ATOM 5656 N N . SER B 1 328 ? -32.917 -60.226 31.439 1.00 61.30 ? 301 SER A N 1 ATOM 5657 C CA . SER B 1 328 ? -31.967 -61.297 31.084 1.00 62.12 ? 301 SER A CA 1 ATOM 5658 C C . SER B 1 328 ? -30.516 -61.003 31.436 1.00 61.03 ? 301 SER A C 1 ATOM 5659 O O . SER B 1 328 ? -29.622 -61.512 30.782 1.00 67.98 ? 301 SER A O 1 ATOM 5660 C CB . SER B 1 328 ? -31.995 -61.491 29.578 1.00 59.70 ? 301 SER A CB 1 ATOM 5661 O OG . SER B 1 328 ? -33.296 -61.787 29.164 1.00 66.70 ? 301 SER A OG 1 ATOM 5662 N N . SER B 1 329 ? -30.256 -60.156 32.418 1.00 59.22 ? 302 SER A N 1 ATOM 5663 C CA . SER B 1 329 ? -28.918 -59.575 32.520 1.00 57.15 ? 302 SER A CA 1 ATOM 5664 C C . SER B 1 329 ? -28.081 -60.341 33.503 1.00 57.77 ? 302 SER A C 1 ATOM 5665 O O . SER B 1 329 ? -28.448 -60.486 34.673 1.00 54.39 ? 302 SER A O 1 ATOM 5666 C CB . SER B 1 329 ? -28.989 -58.113 32.942 1.00 55.13 ? 302 SER A CB 1 ATOM 5667 O OG . SER B 1 329 ? -27.779 -57.700 33.536 1.00 55.17 ? 302 SER A OG 1 ATOM 5668 N N . SER B 1 330 ? -26.927 -60.792 33.035 1.00 57.13 ? 303 SER A N 1 ATOM 5669 C CA . SER B 1 330 ? -26.023 -61.572 33.878 1.00 55.94 ? 303 SER A CA 1 ATOM 5670 C C . SER B 1 330 ? -25.370 -60.770 35.045 1.00 55.55 ? 303 SER A C 1 ATOM 5671 O O . SER B 1 330 ? -24.880 -61.338 36.018 1.00 69.41 ? 303 SER A O 1 ATOM 5672 C CB . SER B 1 330 ? -24.966 -62.205 32.991 1.00 53.02 ? 303 SER A CB 1 ATOM 5673 O OG . SER B 1 330 ? -23.963 -61.265 32.714 1.00 54.06 ? 303 SER A OG 1 ATOM 5674 N N . LEU B 1 331 ? -25.359 -59.454 34.959 1.00 54.28 ? 304 LEU A N 1 ATOM 5675 C CA . LEU B 1 331 ? -24.927 -58.641 36.084 1.00 56.69 ? 304 LEU A CA 1 ATOM 5676 C C . LEU B 1 331 ? -25.878 -58.673 37.277 1.00 58.22 ? 304 LEU A C 1 ATOM 5677 O O . LEU B 1 331 ? -25.456 -58.386 38.388 1.00 55.58 ? 304 LEU A O 1 ATOM 5678 C CB . LEU B 1 331 ? -24.791 -57.185 35.665 1.00 58.44 ? 304 LEU A CB 1 ATOM 5679 C CG . LEU B 1 331 ? -23.697 -56.900 34.667 1.00 62.08 ? 304 LEU A CG 1 ATOM 5680 C CD1 . LEU B 1 331 ? -23.746 -55.452 34.182 1.00 67.99 ? 304 LEU A CD1 1 ATOM 5681 C CD2 . LEU B 1 331 ? -22.372 -57.216 35.316 1.00 63.42 ? 304 LEU A CD2 1 ATOM 5682 N N . ILE B 1 332 ? -27.155 -58.969 37.040 1.00 62.72 ? 305 ILE A N 1 ATOM 5683 C CA . ILE B 1 332 ? -28.175 -59.001 38.106 1.00 63.12 ? 305 ILE A CA 1 ATOM 5684 C C . ILE B 1 332 ? -28.648 -60.434 38.409 1.00 61.50 ? 305 ILE A C 1 ATOM 5685 O O . ILE B 1 332 ? -28.964 -60.768 39.553 1.00 59.17 ? 305 ILE A O 1 ATOM 5686 C CB . ILE B 1 332 ? -29.440 -58.158 37.718 1.00 66.23 ? 305 ILE A CB 1 ATOM 5687 C CG1 . ILE B 1 332 ? -29.074 -56.770 37.138 1.00 63.13 ? 305 ILE A CG1 1 ATOM 5688 C CG2 . ILE B 1 332 ? -30.400 -58.028 38.906 1.00 64.34 ? 305 ILE A CG2 1 ATOM 5689 C CD1 . ILE B 1 332 ? -28.411 -55.775 38.085 1.00 57.97 ? 305 ILE A CD1 1 ATOM 5690 N N . ALA B 1 333 ? -28.761 -61.250 37.365 1.00 62.98 ? 306 ALA A N 1 ATOM 5691 C CA . ALA B 1 333 ? -29.189 -62.637 37.497 1.00 64.73 ? 306 ALA A CA 1 ATOM 5692 C C . ALA B 1 333 ? -28.041 -63.477 38.041 1.00 60.91 ? 306 ALA A C 1 ATOM 5693 O O . ALA B 1 333 ? -27.473 -64.279 37.323 1.00 64.17 ? 306 ALA A O 1 ATOM 5694 C CB . ALA B 1 333 ? -29.661 -63.183 36.143 1.00 63.91 ? 306 ALA A CB 1 ATOM 5695 N N . MET B 1 334 ? -27.744 -63.296 39.324 1.00 63.58 ? 307 MET A N 1 ATOM 5696 C CA . MET B 1 334 ? -26.630 -63.946 40.003 1.00 69.05 ? 307 MET A CA 1 ATOM 5697 C C . MET B 1 334 ? -27.119 -64.685 41.244 1.00 71.11 ? 307 MET A C 1 ATOM 5698 O O . MET B 1 334 ? -27.799 -64.099 42.093 1.00 72.85 ? 307 MET A O 1 ATOM 5699 C CB . MET B 1 334 ? -25.598 -62.902 40.410 1.00 76.44 ? 307 MET A CB 1 ATOM 5700 C CG . MET B 1 334 ? -24.919 -62.237 39.216 1.00 84.58 ? 307 MET A CG 1 ATOM 5701 S SD . MET B 1 334 ? -23.178 -61.894 39.512 1.00 90.47 ? 307 MET A SD 1 ATOM 5702 C CE . MET B 1 334 ? -22.568 -63.581 39.608 1.00 91.92 ? 307 MET A CE 1 ATOM 5703 N N . PRO B 1 335 ? -26.753 -65.971 41.380 1.00 72.85 ? 308 PRO A N 1 ATOM 5704 C CA . PRO B 1 335 ? -27.349 -66.789 42.439 1.00 69.40 ? 308 PRO A CA 1 ATOM 5705 C C . PRO B 1 335 ? -27.226 -66.204 43.828 1.00 68.47 ? 308 PRO A C 1 ATOM 5706 O O . PRO B 1 335 ? -28.112 -66.400 44.640 1.00 68.81 ? 308 PRO A O 1 ATOM 5707 C CB . PRO B 1 335 ? -26.563 -68.089 42.360 1.00 67.86 ? 308 PRO A CB 1 ATOM 5708 C CG . PRO B 1 335 ? -26.107 -68.135 40.942 1.00 72.92 ? 308 PRO A CG 1 ATOM 5709 C CD . PRO B 1 335 ? -25.722 -66.720 40.649 1.00 70.37 ? 308 PRO A CD 1 ATOM 5710 N N . GLN B 1 336 ? -26.151 -65.482 44.109 1.00 67.55 ? 309 GLN A N 1 ATOM 5711 C CA . GLN B 1 336 ? -26.026 -64.863 45.418 1.00 65.85 ? 309 GLN A CA 1 ATOM 5712 C C . GLN B 1 336 ? -26.961 -63.672 45.633 1.00 67.81 ? 309 GLN A C 1 ATOM 5713 O O . GLN B 1 336 ? -26.962 -63.093 46.722 1.00 65.98 ? 309 GLN A O 1 ATOM 5714 C CB . GLN B 1 336 ? -24.576 -64.455 45.721 1.00 71.04 ? 309 GLN A CB 1 ATOM 5715 C CG . GLN B 1 336 ? -23.991 -63.301 44.915 1.00 71.49 ? 309 GLN A CG 1 ATOM 5716 C CD . GLN B 1 336 ? -23.254 -63.756 43.669 1.00 78.13 ? 309 GLN A CD 1 ATOM 5717 O OE1 . GLN B 1 336 ? -23.514 -64.839 43.130 1.00 73.86 ? 309 GLN A OE1 1 ATOM 5718 N NE2 . GLN B 1 336 ? -22.347 -62.910 43.180 1.00 87.62 ? 309 GLN A NE2 1 ATOM 5719 N N . TYR B 1 337 ? -27.725 -63.268 44.615 1.00 67.99 ? 310 TYR A N 1 ATOM 5720 C CA . TYR B 1 337 ? -28.763 -62.261 44.835 1.00 66.76 ? 310 TYR A CA 1 ATOM 5721 C C . TYR B 1 337 ? -30.183 -62.859 44.879 1.00 66.79 ? 310 TYR A C 1 ATOM 5722 O O . TYR B 1 337 ? -31.157 -62.123 44.993 1.00 74.22 ? 310 TYR A O 1 ATOM 5723 C CB . TYR B 1 337 ? -28.742 -61.198 43.747 1.00 67.34 ? 310 TYR A CB 1 ATOM 5724 C CG . TYR B 1 337 ? -27.430 -60.525 43.438 1.00 64.43 ? 310 TYR A CG 1 ATOM 5725 C CD1 . TYR B 1 337 ? -26.474 -60.281 44.412 1.00 65.87 ? 310 TYR A CD1 1 ATOM 5726 C CD2 . TYR B 1 337 ? -27.182 -60.079 42.161 1.00 63.18 ? 310 TYR A CD2 1 ATOM 5727 C CE1 . TYR B 1 337 ? -25.287 -59.636 44.101 1.00 65.89 ? 310 TYR A CE1 1 ATOM 5728 C CE2 . TYR B 1 337 ? -26.010 -59.436 41.837 1.00 69.62 ? 310 TYR A CE2 1 ATOM 5729 C CZ . TYR B 1 337 ? -25.066 -59.216 42.799 1.00 67.85 ? 310 TYR A CZ 1 ATOM 5730 O OH . TYR B 1 337 ? -23.924 -58.579 42.407 1.00 72.26 ? 310 TYR A OH 1 ATOM 5731 N N . PHE B 1 338 ? -30.315 -64.174 44.810 1.00 59.50 ? 311 PHE A N 1 ATOM 5732 C CA . PHE B 1 338 ? -31.610 -64.792 44.545 1.00 60.93 ? 311 PHE A CA 1 ATOM 5733 C C . PHE B 1 338 ? -32.630 -64.631 45.667 1.00 65.35 ? 311 PHE A C 1 ATOM 5734 O O . PHE B 1 338 ? -33.838 -64.753 45.432 1.00 61.86 ? 311 PHE A O 1 ATOM 5735 C CB . PHE B 1 338 ? -31.421 -66.267 44.271 1.00 64.83 ? 311 PHE A CB 1 ATOM 5736 C CG . PHE B 1 338 ? -32.578 -66.911 43.590 1.00 65.16 ? 311 PHE A CG 1 ATOM 5737 C CD1 . PHE B 1 338 ? -32.741 -66.782 42.228 1.00 67.05 ? 311 PHE A CD1 1 ATOM 5738 C CD2 . PHE B 1 338 ? -33.492 -67.672 44.308 1.00 66.20 ? 311 PHE A CD2 1 ATOM 5739 C CE1 . PHE B 1 338 ? -33.801 -67.400 41.572 1.00 67.45 ? 311 PHE A CE1 1 ATOM 5740 C CE2 . PHE B 1 338 ? -34.547 -68.298 43.663 1.00 68.25 ? 311 PHE A CE2 1 ATOM 5741 C CZ . PHE B 1 338 ? -34.698 -68.160 42.286 1.00 68.81 ? 311 PHE A CZ 1 ATOM 5742 N N . HIS B 1 339 ? -32.147 -64.375 46.879 1.00 65.84 ? 312 HIS A N 1 ATOM 5743 C CA . HIS B 1 339 ? -33.023 -64.108 48.034 1.00 67.13 ? 312 HIS A CA 1 ATOM 5744 C C . HIS B 1 339 ? -33.678 -62.727 47.932 1.00 65.85 ? 312 HIS A C 1 ATOM 5745 O O . HIS B 1 339 ? -34.658 -62.410 48.622 1.00 63.48 ? 312 HIS A O 1 ATOM 5746 C CB . HIS B 1 339 ? -32.267 -64.277 49.366 1.00 73.96 ? 312 HIS A CB 1 ATOM 5747 C CG . HIS B 1 339 ? -31.127 -63.316 49.558 1.00 82.92 ? 312 HIS A CG 1 ATOM 5748 N ND1 . HIS B 1 339 ? -29.915 -63.442 48.904 1.00 84.76 ? 312 HIS A ND1 1 ATOM 5749 C CD2 . HIS B 1 339 ? -31.012 -62.221 50.348 1.00 88.15 ? 312 HIS A CD2 1 ATOM 5750 C CE1 . HIS B 1 339 ? -29.116 -62.456 49.268 1.00 85.72 ? 312 HIS A CE1 1 ATOM 5751 N NE2 . HIS B 1 339 ? -29.755 -61.702 50.145 1.00 85.91 ? 312 HIS A NE2 1 ATOM 5752 N N . VAL B 1 340 ? -33.132 -61.899 47.055 1.00 68.31 ? 313 VAL A N 1 ATOM 5753 C CA . VAL B 1 340 ? -33.707 -60.589 46.765 1.00 66.21 ? 313 VAL A CA 1 ATOM 5754 C C . VAL B 1 340 ? -34.397 -60.588 45.417 1.00 61.66 ? 313 VAL A C 1 ATOM 5755 O O . VAL B 1 340 ? -35.521 -60.120 45.269 1.00 64.75 ? 313 VAL A O 1 ATOM 5756 C CB . VAL B 1 340 ? -32.605 -59.518 46.778 1.00 63.65 ? 313 VAL A CB 1 ATOM 5757 C CG1 . VAL B 1 340 ? -33.038 -58.271 46.016 1.00 61.00 ? 313 VAL A CG1 1 ATOM 5758 C CG2 . VAL B 1 340 ? -32.212 -59.212 48.219 1.00 63.92 ? 313 VAL A CG2 1 ATOM 5759 N N . VAL B 1 341 ? -33.718 -61.150 44.441 1.00 60.62 ? 314 VAL A N 1 ATOM 5760 C CA . VAL B 1 341 ? -34.064 -60.934 43.072 1.00 60.54 ? 314 VAL A CA 1 ATOM 5761 C C . VAL B 1 341 ? -34.854 -62.087 42.522 1.00 55.00 ? 314 VAL A C 1 ATOM 5762 O O . VAL B 1 341 ? -35.323 -62.012 41.411 1.00 51.80 ? 314 VAL A O 1 ATOM 5763 C CB . VAL B 1 341 ? -32.757 -60.744 42.279 1.00 65.58 ? 314 VAL A CB 1 ATOM 5764 C CG1 . VAL B 1 341 ? -32.256 -62.067 41.726 1.00 65.34 ? 314 VAL A CG1 1 ATOM 5765 C CG2 . VAL B 1 341 ? -32.927 -59.700 41.199 1.00 69.71 ? 314 VAL A CG2 1 ATOM 5766 N N . GLY B 1 342 ? -34.984 -63.170 43.287 1.00 56.49 ? 315 GLY A N 1 ATOM 5767 C CA . GLY B 1 342 ? -35.673 -64.371 42.812 1.00 53.46 ? 315 GLY A CA 1 ATOM 5768 C C . GLY B 1 342 ? -37.152 -64.145 42.518 1.00 52.52 ? 315 GLY A C 1 ATOM 5769 O O . GLY B 1 342 ? -37.866 -63.443 43.251 1.00 44.64 ? 315 GLY A O 1 ATOM 5770 N N . GLY B 1 343 ? -37.613 -64.746 41.436 1.00 53.88 ? 316 GLY A N 1 ATOM 5771 C CA . GLY B 1 343 ? -39.007 -64.650 41.054 1.00 57.44 ? 316 GLY A CA 1 ATOM 5772 C C . GLY B 1 343 ? -39.361 -63.392 40.292 1.00 64.19 ? 316 GLY A C 1 ATOM 5773 O O . GLY B 1 343 ? -40.538 -63.100 40.109 1.00 66.72 ? 316 GLY A O 1 ATOM 5774 N N . THR B 1 344 ? -38.373 -62.640 39.806 1.00 65.27 ? 317 THR A N 1 ATOM 5775 C CA . THR B 1 344 ? -38.729 -61.466 39.042 1.00 61.38 ? 317 THR A CA 1 ATOM 5776 C C . THR B 1 344 ? -39.418 -61.910 37.774 1.00 57.88 ? 317 THR A C 1 ATOM 5777 O O . THR B 1 344 ? -39.162 -62.987 37.268 1.00 51.72 ? 317 THR A O 1 ATOM 5778 C CB . THR B 1 344 ? -37.555 -60.513 38.705 1.00 66.21 ? 317 THR A CB 1 ATOM 5779 O OG1 . THR B 1 344 ? -36.908 -60.890 37.482 1.00 66.74 ? 317 THR A OG1 1 ATOM 5780 C CG2 . THR B 1 344 ? -36.577 -60.439 39.832 1.00 64.01 ? 317 THR A CG2 1 ATOM 5781 N N . ILE B 1 345 ? -40.298 -61.047 37.283 1.00 60.52 ? 318 ILE A N 1 ATOM 5782 C CA . ILE B 1 345 ? -41.058 -61.272 36.066 1.00 60.02 ? 318 ILE A CA 1 ATOM 5783 C C . ILE B 1 345 ? -40.626 -60.164 35.123 1.00 59.06 ? 318 ILE A C 1 ATOM 5784 O O . ILE B 1 345 ? -40.515 -59.008 35.551 1.00 52.21 ? 318 ILE A O 1 ATOM 5785 C CB . ILE B 1 345 ? -42.577 -61.151 36.307 1.00 63.66 ? 318 ILE A CB 1 ATOM 5786 C CG1 . ILE B 1 345 ? -43.044 -62.186 37.347 1.00 67.18 ? 318 ILE A CG1 1 ATOM 5787 C CG2 . ILE B 1 345 ? -43.342 -61.324 34.997 1.00 62.75 ? 318 ILE A CG2 1 ATOM 5788 C CD1 . ILE B 1 345 ? -44.284 -61.776 38.098 1.00 62.70 ? 318 ILE A CD1 1 ATOM 5789 N N . GLY B 1 346 ? -40.421 -60.537 33.854 1.00 55.05 ? 319 GLY A N 1 ATOM 5790 C CA . GLY B 1 346 ? -39.758 -59.702 32.879 1.00 54.41 ? 319 GLY A CA 1 ATOM 5791 C C . GLY B 1 346 ? -40.121 -59.962 31.430 1.00 54.49 ? 319 GLY A C 1 ATOM 5792 O O . GLY B 1 346 ? -40.948 -60.799 31.136 1.00 57.79 ? 319 GLY A O 1 ATOM 5793 N N . PHE B 1 347 ? -39.518 -59.201 30.524 1.00 54.61 ? 320 PHE A N 1 ATOM 5794 C CA . PHE B 1 347 ? -39.859 -59.282 29.112 1.00 55.71 ? 320 PHE A CA 1 ATOM 5795 C C . PHE B 1 347 ? -38.640 -59.674 28.354 1.00 49.79 ? 320 PHE A C 1 ATOM 5796 O O . PHE B 1 347 ? -37.546 -59.424 28.813 1.00 52.28 ? 320 PHE A O 1 ATOM 5797 C CB . PHE B 1 347 ? -40.406 -57.962 28.610 1.00 53.28 ? 320 PHE A CB 1 ATOM 5798 C CG . PHE B 1 347 ? -41.666 -57.573 29.294 1.00 60.81 ? 320 PHE A CG 1 ATOM 5799 C CD1 . PHE B 1 347 ? -42.885 -57.946 28.780 1.00 67.47 ? 320 PHE A CD1 1 ATOM 5800 C CD2 . PHE B 1 347 ? -41.629 -56.906 30.495 1.00 64.09 ? 320 PHE A CD2 1 ATOM 5801 C CE1 . PHE B 1 347 ? -44.052 -57.613 29.428 1.00 69.01 ? 320 PHE A CE1 1 ATOM 5802 C CE2 . PHE B 1 347 ? -42.789 -56.577 31.152 1.00 67.15 ? 320 PHE A CE2 1 ATOM 5803 C CZ . PHE B 1 347 ? -44.007 -56.927 30.617 1.00 66.97 ? 320 PHE A CZ 1 ATOM 5804 N N . ALA B 1 348 ? -38.842 -60.346 27.231 1.00 46.20 ? 321 ALA A N 1 ATOM 5805 C CA . ALA B 1 348 ? -37.752 -60.828 26.411 1.00 46.91 ? 321 ALA A CA 1 ATOM 5806 C C . ALA B 1 348 ? -38.183 -60.750 24.968 1.00 55.15 ? 321 ALA A C 1 ATOM 5807 O O . ALA B 1 348 ? -39.373 -60.951 24.652 1.00 50.14 ? 321 ALA A O 1 ATOM 5808 C CB . ALA B 1 348 ? -37.376 -62.243 26.778 1.00 45.01 ? 321 ALA A CB 1 ATOM 5809 N N . LEU B 1 349 ? -37.234 -60.419 24.090 1.00 60.34 ? 322 LEU A N 1 ATOM 5810 C CA . LEU B 1 349 ? -37.551 -60.326 22.663 1.00 62.74 ? 322 LEU A CA 1 ATOM 5811 C C . LEU B 1 349 ? -37.768 -61.729 22.093 1.00 64.17 ? 322 LEU A C 1 ATOM 5812 O O . LEU B 1 349 ? -37.353 -62.700 22.710 1.00 61.86 ? 322 LEU A O 1 ATOM 5813 C CB . LEU B 1 349 ? -36.419 -59.634 21.906 1.00 65.58 ? 322 LEU A CB 1 ATOM 5814 C CG . LEU B 1 349 ? -36.259 -58.112 21.990 1.00 70.37 ? 322 LEU A CG 1 ATOM 5815 C CD1 . LEU B 1 349 ? -37.597 -57.394 22.149 1.00 67.08 ? 322 LEU A CD1 1 ATOM 5816 C CD2 . LEU B 1 349 ? -35.298 -57.742 23.115 1.00 79.39 ? 322 LEU A CD2 1 ATOM 5817 N N . LYS B 1 350 ? -38.408 -61.839 20.924 1.00 67.24 ? 323 LYS A N 1 ATOM 5818 C CA . LYS B 1 350 ? -38.446 -63.126 20.197 1.00 66.16 ? 323 LYS A CA 1 ATOM 5819 C C . LYS B 1 350 ? -37.022 -63.520 19.892 1.00 65.12 ? 323 LYS A C 1 ATOM 5820 O O . LYS B 1 350 ? -36.209 -62.678 19.532 1.00 67.58 ? 323 LYS A O 1 ATOM 5821 C CB . LYS B 1 350 ? -39.245 -63.068 18.871 1.00 62.71 ? 323 LYS A CB 1 ATOM 5822 N N . ALA B 1 351 ? -36.719 -64.801 20.057 1.00 71.59 ? 324 ALA A N 1 ATOM 5823 C CA . ALA B 1 351 ? -35.438 -65.381 19.609 1.00 68.86 ? 324 ALA A CA 1 ATOM 5824 C C . ALA B 1 351 ? -35.351 -65.459 18.082 1.00 66.01 ? 324 ALA A C 1 ATOM 5825 O O . ALA B 1 351 ? -36.379 -65.433 17.369 1.00 58.88 ? 324 ALA A O 1 ATOM 5826 C CB . ALA B 1 351 ? -35.253 -66.767 20.204 1.00 72.70 ? 324 ALA A CB 1 ATOM 5827 N N . GLY B 1 352 ? -34.116 -65.530 17.589 1.00 67.39 ? 325 GLY A N 1 ATOM 5828 C CA . GLY B 1 352 ? -33.840 -65.709 16.154 1.00 69.52 ? 325 GLY A CA 1 ATOM 5829 C C . GLY B 1 352 ? -32.769 -66.766 15.955 1.00 70.80 ? 325 GLY A C 1 ATOM 5830 O O . GLY B 1 352 ? -32.045 -67.092 16.889 1.00 75.14 ? 325 GLY A O 1 ATOM 5831 N N . GLN B 1 353 ? -32.669 -67.318 14.753 1.00 79.64 ? 326 GLN A N 1 ATOM 5832 C CA . GLN B 1 353 ? -31.672 -68.353 14.475 1.00 84.49 ? 326 GLN A CA 1 ATOM 5833 C C . GLN B 1 353 ? -30.627 -67.828 13.518 1.00 78.93 ? 326 GLN A C 1 ATOM 5834 O O . GLN B 1 353 ? -30.964 -67.197 12.521 1.00 70.50 ? 326 GLN A O 1 ATOM 5835 C CB . GLN B 1 353 ? -32.327 -69.576 13.854 1.00 95.41 ? 326 GLN A CB 1 ATOM 5836 C CG . GLN B 1 353 ? -33.011 -70.507 14.840 1.00 102.67 ? 326 GLN A CG 1 ATOM 5837 C CD . GLN B 1 353 ? -33.671 -71.702 14.149 1.00 111.29 ? 326 GLN A CD 1 ATOM 5838 O OE1 . GLN B 1 353 ? -33.466 -71.956 12.952 1.00 109.41 ? 326 GLN A OE1 1 ATOM 5839 N NE2 . GLN B 1 353 ? -34.466 -72.445 14.907 1.00 112.04 ? 326 GLN A NE2 1 ATOM 5840 N N . ILE B 1 354 ? -29.365 -68.092 13.834 1.00 84.94 ? 327 ILE A N 1 ATOM 5841 C CA . ILE B 1 354 ? -28.249 -67.780 12.939 1.00 90.49 ? 327 ILE A CA 1 ATOM 5842 C C . ILE B 1 354 ? -27.399 -69.055 12.748 1.00 92.86 ? 327 ILE A C 1 ATOM 5843 O O . ILE B 1 354 ? -26.495 -69.347 13.557 1.00 90.07 ? 327 ILE A O 1 ATOM 5844 C CB . ILE B 1 354 ? -27.361 -66.618 13.462 1.00 87.11 ? 327 ILE A CB 1 ATOM 5845 C CG1 . ILE B 1 354 ? -28.206 -65.463 13.999 1.00 79.44 ? 327 ILE A CG1 1 ATOM 5846 C CG2 . ILE B 1 354 ? -26.451 -66.103 12.351 1.00 89.93 ? 327 ILE A CG2 1 ATOM 5847 C CD1 . ILE B 1 354 ? -27.375 -64.331 14.579 1.00 77.25 ? 327 ILE A CD1 1 ATOM 5848 N N . PRO B 1 355 ? -27.709 -69.839 11.694 1.00 89.62 ? 328 PRO A N 1 ATOM 5849 C CA . PRO B 1 355 ? -26.841 -70.950 11.307 1.00 84.53 ? 328 PRO A CA 1 ATOM 5850 C C . PRO B 1 355 ? -25.405 -70.488 10.972 1.00 85.25 ? 328 PRO A C 1 ATOM 5851 O O . PRO B 1 355 ? -25.203 -69.477 10.273 1.00 71.19 ? 328 PRO A O 1 ATOM 5852 C CB . PRO B 1 355 ? -27.535 -71.524 10.068 1.00 84.17 ? 328 PRO A CB 1 ATOM 5853 C CG . PRO B 1 355 ? -28.963 -71.125 10.207 1.00 88.11 ? 328 PRO A CG 1 ATOM 5854 C CD . PRO B 1 355 ? -28.930 -69.782 10.869 1.00 88.90 ? 328 PRO A CD 1 ATOM 5855 N N . GLY B 1 356 ? -24.428 -71.219 11.510 1.00 84.12 ? 329 GLY A N 1 ATOM 5856 C CA . GLY B 1 356 ? -23.020 -70.954 11.254 1.00 80.83 ? 329 GLY A CA 1 ATOM 5857 C C . GLY B 1 356 ? -22.385 -70.101 12.325 1.00 88.27 ? 329 GLY A C 1 ATOM 5858 O O . GLY B 1 356 ? -21.155 -70.100 12.468 1.00 90.58 ? 329 GLY A O 1 ATOM 5859 N N . PHE B 1 357 ? -23.216 -69.385 13.088 1.00 88.29 ? 330 PHE A N 1 ATOM 5860 C CA . PHE B 1 357 ? -22.731 -68.334 13.967 1.00 80.29 ? 330 PHE A CA 1 ATOM 5861 C C . PHE B 1 357 ? -22.009 -68.924 15.161 1.00 78.57 ? 330 PHE A C 1 ATOM 5862 O O . PHE B 1 357 ? -20.926 -68.474 15.515 1.00 78.94 ? 330 PHE A O 1 ATOM 5863 C CB . PHE B 1 357 ? -23.885 -67.419 14.410 1.00 84.72 ? 330 PHE A CB 1 ATOM 5864 C CG . PHE B 1 357 ? -23.454 -66.276 15.289 1.00 71.48 ? 330 PHE A CG 1 ATOM 5865 C CD1 . PHE B 1 357 ? -22.498 -65.378 14.845 1.00 67.46 ? 330 PHE A CD1 1 ATOM 5866 C CD2 . PHE B 1 357 ? -24.004 -66.104 16.550 1.00 69.46 ? 330 PHE A CD2 1 ATOM 5867 C CE1 . PHE B 1 357 ? -22.074 -64.336 15.642 1.00 65.45 ? 330 PHE A CE1 1 ATOM 5868 C CE2 . PHE B 1 357 ? -23.596 -65.055 17.354 1.00 70.66 ? 330 PHE A CE2 1 ATOM 5869 C CZ . PHE B 1 357 ? -22.622 -64.173 16.899 1.00 69.90 ? 330 PHE A CZ 1 ATOM 5870 N N . ARG B 1 358 ? -22.586 -69.951 15.769 1.00 85.41 ? 331 ARG A N 1 ATOM 5871 C CA . ARG B 1 358 ? -21.914 -70.595 16.900 1.00 84.99 ? 331 ARG A CA 1 ATOM 5872 C C . ARG B 1 358 ? -20.504 -71.057 16.533 1.00 85.94 ? 331 ARG A C 1 ATOM 5873 O O . ARG B 1 358 ? -19.551 -70.804 17.275 1.00 80.18 ? 331 ARG A O 1 ATOM 5874 C CB . ARG B 1 358 ? -22.723 -71.774 17.457 1.00 82.76 ? 331 ARG A CB 1 ATOM 5875 C CG . ARG B 1 358 ? -22.142 -72.263 18.777 1.00 83.53 ? 331 ARG A CG 1 ATOM 5876 C CD . ARG B 1 358 ? -23.135 -73.037 19.622 1.00 89.19 ? 331 ARG A CD 1 ATOM 5877 N NE . ARG B 1 358 ? -22.832 -72.851 21.041 1.00 93.96 ? 331 ARG A NE 1 ATOM 5878 C CZ . ARG B 1 358 ? -23.623 -72.252 21.930 1.00 98.14 ? 331 ARG A CZ 1 ATOM 5879 N NH1 . ARG B 1 358 ? -24.817 -71.781 21.591 1.00 107.25 ? 331 ARG A NH1 1 ATOM 5880 N NH2 . ARG B 1 358 ? -23.221 -72.141 23.187 1.00 107.35 ? 331 ARG A NH2 1 ATOM 5881 N N . GLU B 1 359 ? -20.382 -71.738 15.390 1.00 94.13 ? 332 GLU A N 1 ATOM 5882 C CA . GLU B 1 359 ? -19.071 -72.151 14.864 1.00 91.53 ? 332 GLU A CA 1 ATOM 5883 C C . GLU B 1 359 ? -18.138 -70.939 14.652 1.00 83.56 ? 332 GLU A C 1 ATOM 5884 O O . GLU B 1 359 ? -16.961 -70.994 14.993 1.00 79.20 ? 332 GLU A O 1 ATOM 5885 C CB . GLU B 1 359 ? -19.233 -72.950 13.559 1.00 87.38 ? 332 GLU A CB 1 ATOM 5886 N N . PHE B 1 360 ? -18.677 -69.849 14.110 1.00 80.96 ? 333 PHE A N 1 ATOM 5887 C CA . PHE B 1 360 ? -17.898 -68.643 13.847 1.00 81.87 ? 333 PHE A CA 1 ATOM 5888 C C . PHE B 1 360 ? -17.301 -68.027 15.120 1.00 77.96 ? 333 PHE A C 1 ATOM 5889 O O . PHE B 1 360 ? -16.158 -67.546 15.144 1.00 67.75 ? 333 PHE A O 1 ATOM 5890 C CB . PHE B 1 360 ? -18.779 -67.624 13.141 1.00 86.44 ? 333 PHE A CB 1 ATOM 5891 C CG . PHE B 1 360 ? -18.106 -66.311 12.911 1.00 95.03 ? 333 PHE A CG 1 ATOM 5892 C CD1 . PHE B 1 360 ? -17.438 -66.065 11.720 1.00 97.07 ? 333 PHE A CD1 1 ATOM 5893 C CD2 . PHE B 1 360 ? -18.142 -65.313 13.884 1.00 92.95 ? 333 PHE A CD2 1 ATOM 5894 C CE1 . PHE B 1 360 ? -16.818 -64.848 11.497 1.00 98.66 ? 333 PHE A CE1 1 ATOM 5895 C CE2 . PHE B 1 360 ? -17.521 -64.098 13.671 1.00 93.92 ? 333 PHE A CE2 1 ATOM 5896 C CZ . PHE B 1 360 ? -16.859 -63.865 12.474 1.00 97.78 ? 333 PHE A CZ 1 ATOM 5897 N N . LEU B 1 361 ? -18.100 -68.040 16.177 1.00 82.96 ? 334 LEU A N 1 ATOM 5898 C CA . LEU B 1 361 ? -17.684 -67.529 17.479 1.00 83.96 ? 334 LEU A CA 1 ATOM 5899 C C . LEU B 1 361 ? -16.540 -68.309 18.091 1.00 82.18 ? 334 LEU A C 1 ATOM 5900 O O . LEU B 1 361 ? -15.925 -67.819 19.020 1.00 83.61 ? 334 LEU A O 1 ATOM 5901 C CB . LEU B 1 361 ? -18.853 -67.591 18.468 1.00 90.91 ? 334 LEU A CB 1 ATOM 5902 C CG . LEU B 1 361 ? -19.824 -66.442 18.752 1.00 87.59 ? 334 LEU A CG 1 ATOM 5903 C CD1 . LEU B 1 361 ? -19.627 -65.225 17.859 1.00 90.32 ? 334 LEU A CD1 1 ATOM 5904 C CD2 . LEU B 1 361 ? -21.242 -66.990 18.677 1.00 82.34 ? 334 LEU A CD2 1 ATOM 5905 N N . LYS B 1 362 ? -16.298 -69.539 17.632 1.00 95.86 ? 335 LYS A N 1 ATOM 5906 C CA . LYS B 1 362 ? -15.220 -70.393 18.192 1.00 93.53 ? 335 LYS A CA 1 ATOM 5907 C C . LYS B 1 362 ? -13.890 -70.269 17.431 1.00 85.65 ? 335 LYS A C 1 ATOM 5908 O O . LYS B 1 362 ? -12.849 -70.688 17.941 1.00 76.26 ? 335 LYS A O 1 ATOM 5909 C CB . LYS B 1 362 ? -15.662 -71.862 18.273 1.00 96.60 ? 335 LYS A CB 1 ATOM 5910 C CG . LYS B 1 362 ? -16.639 -72.167 19.414 1.00 105.07 ? 335 LYS A CG 1 ATOM 5911 C CD . LYS B 1 362 ? -17.238 -73.574 19.301 1.00 104.80 ? 335 LYS A CD 1 ATOM 5912 C CE . LYS B 1 362 ? -18.209 -73.901 20.425 1.00 100.38 ? 335 LYS A CE 1 ATOM 5913 N NZ . LYS B 1 362 ? -18.903 -75.200 20.180 1.00 98.10 ? 335 LYS A NZ 1 ATOM 5914 N N . LYS B 1 363 ? -13.915 -69.664 16.242 1.00 78.87 ? 336 LYS A N 1 ATOM 5915 C CA . LYS B 1 363 ? -12.679 -69.361 15.518 1.00 82.99 ? 336 LYS A CA 1 ATOM 5916 C C . LYS B 1 363 ? -11.932 -68.089 16.024 1.00 86.83 ? 336 LYS A C 1 ATOM 5917 O O . LYS B 1 363 ? -10.989 -67.611 15.373 1.00 83.07 ? 336 LYS A O 1 ATOM 5918 C CB . LYS B 1 363 ? -12.970 -69.257 14.013 1.00 77.88 ? 336 LYS A CB 1 ATOM 5919 N N . VAL B 1 364 ? -12.323 -67.548 17.177 1.00 87.07 ? 337 VAL A N 1 ATOM 5920 C CA . VAL B 1 364 ? -11.715 -66.302 17.651 1.00 98.40 ? 337 VAL A CA 1 ATOM 5921 C C . VAL B 1 364 ? -10.275 -66.605 17.959 1.00 95.02 ? 337 VAL A C 1 ATOM 5922 O O . VAL B 1 364 ? -10.010 -67.619 18.584 1.00 103.90 ? 337 VAL A O 1 ATOM 5923 C CB . VAL B 1 364 ? -12.302 -65.763 18.981 1.00 102.43 ? 337 VAL A CB 1 ATOM 5924 C CG1 . VAL B 1 364 ? -12.172 -64.248 19.033 1.00 107.48 ? 337 VAL A CG1 1 ATOM 5925 C CG2 . VAL B 1 364 ? -13.739 -66.159 19.178 1.00 99.52 ? 337 VAL A CG2 1 ATOM 5926 N N . HIS B 1 365 ? -9.349 -65.738 17.557 1.00 98.40 ? 338 HIS A N 1 ATOM 5927 C CA . HIS B 1 365 ? -7.937 -65.936 17.921 1.00 104.04 ? 338 HIS A CA 1 ATOM 5928 C C . HIS B 1 365 ? -7.148 -64.636 17.949 1.00 89.98 ? 338 HIS A C 1 ATOM 5929 O O . HIS B 1 365 ? -7.187 -63.879 16.989 1.00 84.43 ? 338 HIS A O 1 ATOM 5930 C CB . HIS B 1 365 ? -7.242 -66.925 16.962 1.00 111.41 ? 338 HIS A CB 1 ATOM 5931 C CG . HIS B 1 365 ? -6.178 -67.748 17.624 1.00 116.88 ? 338 HIS A CG 1 ATOM 5932 N ND1 . HIS B 1 365 ? -6.474 -68.812 18.450 1.00 122.67 ? 338 HIS A ND1 1 ATOM 5933 C CD2 . HIS B 1 365 ? -4.829 -67.654 17.605 1.00 122.43 ? 338 HIS A CD2 1 ATOM 5934 C CE1 . HIS B 1 365 ? -5.353 -69.345 18.902 1.00 124.26 ? 338 HIS A CE1 1 ATOM 5935 N NE2 . HIS B 1 365 ? -4.340 -68.659 18.406 1.00 130.82 ? 338 HIS A NE2 1 ATOM 5936 N N . PRO B 1 366 ? -6.401 -64.389 19.037 1.00 89.94 ? 339 PRO A N 1 ATOM 5937 C CA . PRO B 1 366 ? -5.587 -63.162 19.094 1.00 93.28 ? 339 PRO A CA 1 ATOM 5938 C C . PRO B 1 366 ? -4.592 -63.047 17.935 1.00 100.18 ? 339 PRO A C 1 ATOM 5939 O O . PRO B 1 366 ? -4.375 -61.949 17.409 1.00 95.90 ? 339 PRO A O 1 ATOM 5940 C CB . PRO B 1 366 ? -4.857 -63.251 20.446 1.00 91.21 ? 339 PRO A CB 1 ATOM 5941 C CG . PRO B 1 366 ? -5.271 -64.535 21.087 1.00 93.41 ? 339 PRO A CG 1 ATOM 5942 C CD . PRO B 1 366 ? -6.400 -65.142 20.305 1.00 92.55 ? 339 PRO A CD 1 ATOM 5943 N N . ARG B 1 367 ? -3.999 -64.175 17.549 1.00 108.24 ? 340 ARG A N 1 ATOM 5944 C CA . ARG B 1 367 ? -3.163 -64.243 16.350 1.00 108.69 ? 340 ARG A CA 1 ATOM 5945 C C . ARG B 1 367 ? -4.030 -64.176 15.096 1.00 99.70 ? 340 ARG A C 1 ATOM 5946 O O . ARG B 1 367 ? -4.129 -63.121 14.482 1.00 93.18 ? 340 ARG A O 1 ATOM 5947 C CB . ARG B 1 367 ? -2.302 -65.520 16.344 1.00 110.18 ? 340 ARG A CB 1 ATOM 5948 N N . LYS B 1 368 ? -4.679 -65.292 14.755 1.00 110.31 ? 341 LYS A N 1 ATOM 5949 C CA . LYS B 1 368 ? -5.385 -65.472 13.471 1.00 115.94 ? 341 LYS A CA 1 ATOM 5950 C C . LYS B 1 368 ? -6.403 -64.370 13.103 1.00 118.11 ? 341 LYS A C 1 ATOM 5951 O O . LYS B 1 368 ? -6.578 -64.087 11.916 1.00 118.42 ? 341 LYS A O 1 ATOM 5952 C CB . LYS B 1 368 ? -6.059 -66.860 13.418 1.00 110.20 ? 341 LYS A CB 1 ATOM 5953 N N . SER B 1 369 ? -7.066 -63.764 14.098 1.00 114.65 ? 342 SER A N 1 ATOM 5954 C CA . SER B 1 369 ? -8.020 -62.664 13.851 1.00 102.96 ? 342 SER A CA 1 ATOM 5955 C C . SER B 1 369 ? -7.282 -61.333 13.676 1.00 105.98 ? 342 SER A C 1 ATOM 5956 O O . SER B 1 369 ? -7.146 -60.550 14.624 1.00 95.77 ? 342 SER A O 1 ATOM 5957 C CB . SER B 1 369 ? -9.044 -62.545 14.983 1.00 92.12 ? 342 SER A CB 1 ATOM 5958 O OG . SER B 1 369 ? -9.650 -63.788 15.270 1.00 93.75 ? 342 SER A OG 1 ATOM 5959 N N . VAL B 1 370 ? -6.803 -61.086 12.456 1.00 113.87 ? 343 VAL A N 1 ATOM 5960 C CA . VAL B 1 370 ? -6.005 -59.886 12.161 1.00 109.68 ? 343 VAL A CA 1 ATOM 5961 C C . VAL B 1 370 ? -6.867 -58.620 12.179 1.00 102.46 ? 343 VAL A C 1 ATOM 5962 O O . VAL B 1 370 ? -6.386 -57.572 12.599 1.00 90.60 ? 343 VAL A O 1 ATOM 5963 C CB . VAL B 1 370 ? -5.261 -59.994 10.804 1.00 93.15 ? 343 VAL A CB 1 ATOM 5964 N N . HIS B 1 371 ? -8.133 -58.740 11.758 1.00 101.37 ? 344 HIS A N 1 ATOM 5965 C CA . HIS B 1 371 ? -9.033 -57.589 11.558 1.00 101.50 ? 344 HIS A CA 1 ATOM 5966 C C . HIS B 1 371 ? -9.801 -57.103 12.819 1.00 95.36 ? 344 HIS A C 1 ATOM 5967 O O . HIS B 1 371 ? -10.212 -55.948 12.875 1.00 85.53 ? 344 HIS A O 1 ATOM 5968 C CB . HIS B 1 371 ? -10.044 -57.909 10.447 1.00 108.53 ? 344 HIS A CB 1 ATOM 5969 C CG . HIS B 1 371 ? -9.419 -58.307 9.140 1.00 115.54 ? 344 HIS A CG 1 ATOM 5970 N ND1 . HIS B 1 371 ? -8.751 -57.414 8.327 1.00 120.68 ? 344 HIS A ND1 1 ATOM 5971 C CD2 . HIS B 1 371 ? -9.383 -59.498 8.497 1.00 111.80 ? 344 HIS A CD2 1 ATOM 5972 C CE1 . HIS B 1 371 ? -8.324 -58.039 7.245 1.00 117.99 ? 344 HIS A CE1 1 ATOM 5973 N NE2 . HIS B 1 371 ? -8.696 -59.304 7.323 1.00 119.46 ? 344 HIS A NE2 1 ATOM 5974 N N . ASN B 1 372 ? -9.980 -57.976 13.812 1.00 85.14 ? 345 ASN A N 1 ATOM 5975 C CA . ASN B 1 372 ? -10.734 -57.673 15.034 1.00 74.57 ? 345 ASN A CA 1 ATOM 5976 C C . ASN B 1 372 ? -9.820 -57.387 16.225 1.00 70.49 ? 345 ASN A C 1 ATOM 5977 O O . ASN B 1 372 ? -9.558 -58.238 17.063 1.00 61.94 ? 345 ASN A O 1 ATOM 5978 C CB . ASN B 1 372 ? -11.669 -58.846 15.353 1.00 72.70 ? 345 ASN A CB 1 ATOM 5979 C CG . ASN B 1 372 ? -12.584 -58.599 16.559 1.00 74.16 ? 345 ASN A CG 1 ATOM 5980 O OD1 . ASN B 1 372 ? -12.278 -57.832 17.502 1.00 63.23 ? 345 ASN A OD1 1 ATOM 5981 N ND2 . ASN B 1 372 ? -13.723 -59.299 16.545 1.00 73.90 ? 345 ASN A ND2 1 ATOM 5982 N N . GLY B 1 373 ? -9.391 -56.148 16.336 1.00 73.32 ? 346 GLY A N 1 ATOM 5983 C CA . GLY B 1 373 ? -8.485 -55.754 17.404 1.00 74.63 ? 346 GLY A CA 1 ATOM 5984 C C . GLY B 1 373 ? -9.071 -55.757 18.803 1.00 81.65 ? 346 GLY A C 1 ATOM 5985 O O . GLY B 1 373 ? -8.457 -55.209 19.731 1.00 81.31 ? 346 GLY A O 1 ATOM 5986 N N . PHE B 1 374 ? -10.257 -56.339 18.979 1.00 80.04 ? 347 PHE A N 1 ATOM 5987 C CA . PHE B 1 374 ? -10.771 -56.529 20.328 1.00 78.50 ? 347 PHE A CA 1 ATOM 5988 C C . PHE B 1 374 ? -10.464 -57.920 20.848 1.00 78.92 ? 347 PHE A C 1 ATOM 5989 O O . PHE B 1 374 ? -10.639 -58.184 22.037 1.00 85.43 ? 347 PHE A O 1 ATOM 5990 C CB . PHE B 1 374 ? -12.276 -56.257 20.393 1.00 78.44 ? 347 PHE A CB 1 ATOM 5991 C CG . PHE B 1 374 ? -12.642 -54.825 20.131 1.00 66.69 ? 347 PHE A CG 1 ATOM 5992 C CD1 . PHE B 1 374 ? -12.419 -53.863 21.090 1.00 67.26 ? 347 PHE A CD1 1 ATOM 5993 C CD2 . PHE B 1 374 ? -13.198 -54.451 18.924 1.00 63.62 ? 347 PHE A CD2 1 ATOM 5994 C CE1 . PHE B 1 374 ? -12.742 -52.543 20.852 1.00 65.01 ? 347 PHE A CE1 1 ATOM 5995 C CE2 . PHE B 1 374 ? -13.532 -53.149 18.677 1.00 61.10 ? 347 PHE A CE2 1 ATOM 5996 C CZ . PHE B 1 374 ? -13.302 -52.189 19.641 1.00 66.76 ? 347 PHE A CZ 1 ATOM 5997 N N . ALA B 1 375 ? -10.002 -58.809 19.972 1.00 80.46 ? 348 ALA A N 1 ATOM 5998 C CA . ALA B 1 375 ? -9.792 -60.213 20.353 1.00 76.67 ? 348 ALA A CA 1 ATOM 5999 C C . ALA B 1 375 ? -8.697 -60.414 21.406 1.00 72.40 ? 348 ALA A C 1 ATOM 6000 O O . ALA B 1 375 ? -8.808 -61.304 22.237 1.00 67.29 ? 348 ALA A O 1 ATOM 6001 C CB . ALA B 1 375 ? -9.504 -61.060 19.128 1.00 72.11 ? 348 ALA A CB 1 ATOM 6002 N N . LYS B 1 376 ? -7.648 -59.594 21.368 1.00 72.21 ? 349 LYS A N 1 ATOM 6003 C CA . LYS B 1 376 ? -6.557 -59.723 22.338 1.00 75.33 ? 349 LYS A CA 1 ATOM 6004 C C . LYS B 1 376 ? -7.082 -59.557 23.755 1.00 82.73 ? 349 LYS A C 1 ATOM 6005 O O . LYS B 1 376 ? -6.863 -60.440 24.602 1.00 92.83 ? 349 LYS A O 1 ATOM 6006 C CB . LYS B 1 376 ? -5.411 -58.734 22.075 1.00 69.43 ? 349 LYS A CB 1 ATOM 6007 N N . GLU B 1 377 ? -7.788 -58.453 24.018 1.00 80.98 ? 350 GLU A N 1 ATOM 6008 C CA . GLU B 1 377 ? -8.365 -58.248 25.352 1.00 79.84 ? 350 GLU A CA 1 ATOM 6009 C C . GLU B 1 377 ? -9.436 -59.281 25.651 1.00 75.02 ? 350 GLU A C 1 ATOM 6010 O O . GLU B 1 377 ? -9.607 -59.684 26.797 1.00 72.79 ? 350 GLU A O 1 ATOM 6011 C CB . GLU B 1 377 ? -8.967 -56.863 25.515 1.00 85.16 ? 350 GLU A CB 1 ATOM 6012 C CG . GLU B 1 377 ? -9.487 -56.596 26.930 1.00 84.46 ? 350 GLU A CG 1 ATOM 6013 C CD . GLU B 1 377 ? -9.924 -55.160 27.120 1.00 85.13 ? 350 GLU A CD 1 ATOM 6014 O OE1 . GLU B 1 377 ? -10.360 -54.538 26.116 1.00 83.22 ? 350 GLU A OE1 1 ATOM 6015 O OE2 . GLU B 1 377 ? -9.832 -54.661 28.267 1.00 82.64 ? 350 GLU A OE2 1 ATOM 6016 N N . PHE B 1 378 ? -10.166 -59.702 24.628 1.00 72.75 ? 351 PHE A N 1 ATOM 6017 C CA . PHE B 1 378 ? -11.135 -60.764 24.821 1.00 74.40 ? 351 PHE A CA 1 ATOM 6018 C C . PHE B 1 378 ? -10.396 -61.950 25.418 1.00 75.94 ? 351 PHE A C 1 ATOM 6019 O O . PHE B 1 378 ? -10.786 -62.465 26.456 1.00 77.27 ? 351 PHE A O 1 ATOM 6020 C CB . PHE B 1 378 ? -11.815 -61.156 23.500 1.00 72.31 ? 351 PHE A CB 1 ATOM 6021 C CG . PHE B 1 378 ? -12.557 -62.459 23.570 1.00 78.13 ? 351 PHE A CG 1 ATOM 6022 C CD1 . PHE B 1 378 ? -13.810 -62.527 24.150 1.00 80.89 ? 351 PHE A CD1 1 ATOM 6023 C CD2 . PHE B 1 378 ? -11.990 -63.620 23.084 1.00 83.67 ? 351 PHE A CD2 1 ATOM 6024 C CE1 . PHE B 1 378 ? -14.494 -63.728 24.230 1.00 86.68 ? 351 PHE A CE1 1 ATOM 6025 C CE2 . PHE B 1 378 ? -12.669 -64.823 23.161 1.00 89.94 ? 351 PHE A CE2 1 ATOM 6026 C CZ . PHE B 1 378 ? -13.923 -64.881 23.735 1.00 86.78 ? 351 PHE A CZ 1 ATOM 6027 N N . TRP B 1 379 ? -9.308 -62.345 24.762 1.00 79.75 ? 352 TRP A N 1 ATOM 6028 C CA . TRP B 1 379 ? -8.557 -63.530 25.139 1.00 82.93 ? 352 TRP A CA 1 ATOM 6029 C C . TRP B 1 379 ? -8.060 -63.434 26.571 1.00 78.13 ? 352 TRP A C 1 ATOM 6030 O O . TRP B 1 379 ? -8.356 -64.294 27.407 1.00 72.58 ? 352 TRP A O 1 ATOM 6031 C CB . TRP B 1 379 ? -7.377 -63.738 24.190 1.00 88.49 ? 352 TRP A CB 1 ATOM 6032 C CG . TRP B 1 379 ? -6.923 -65.162 24.169 1.00 94.69 ? 352 TRP A CG 1 ATOM 6033 C CD1 . TRP B 1 379 ? -5.884 -65.703 24.861 1.00 92.09 ? 352 TRP A CD1 1 ATOM 6034 C CD2 . TRP B 1 379 ? -7.513 -66.235 23.423 1.00 97.60 ? 352 TRP A CD2 1 ATOM 6035 N NE1 . TRP B 1 379 ? -5.788 -67.046 24.598 1.00 91.19 ? 352 TRP A NE1 1 ATOM 6036 C CE2 . TRP B 1 379 ? -6.771 -67.400 23.712 1.00 95.64 ? 352 TRP A CE2 1 ATOM 6037 C CE3 . TRP B 1 379 ? -8.593 -66.323 22.536 1.00 91.19 ? 352 TRP A CE3 1 ATOM 6038 C CZ2 . TRP B 1 379 ? -7.075 -68.646 23.146 1.00 91.17 ? 352 TRP A CZ2 1 ATOM 6039 C CZ3 . TRP B 1 379 ? -8.890 -67.554 21.974 1.00 92.01 ? 352 TRP A CZ3 1 ATOM 6040 C CH2 . TRP B 1 379 ? -8.132 -68.700 22.284 1.00 90.26 ? 352 TRP A CH2 1 ATOM 6041 N N . GLU B 1 380 ? -7.344 -62.353 26.838 1.00 76.43 ? 353 GLU A N 1 ATOM 6042 C CA . GLU B 1 380 ? -6.824 -62.039 28.171 1.00 83.99 ? 353 GLU A CA 1 ATOM 6043 C C . GLU B 1 380 ? -7.873 -62.063 29.302 1.00 82.26 ? 353 GLU A C 1 ATOM 6044 O O . GLU B 1 380 ? -7.614 -62.559 30.388 1.00 87.91 ? 353 GLU A O 1 ATOM 6045 C CB . GLU B 1 380 ? -6.126 -60.666 28.131 1.00 88.43 ? 353 GLU A CB 1 ATOM 6046 C CG . GLU B 1 380 ? -4.894 -60.634 27.223 1.00 91.17 ? 353 GLU A CG 1 ATOM 6047 C CD . GLU B 1 380 ? -4.233 -59.275 27.131 1.00 94.72 ? 353 GLU A CD 1 ATOM 6048 O OE1 . GLU B 1 380 ? -4.958 -58.251 27.125 1.00 102.37 ? 353 GLU A OE1 1 ATOM 6049 O OE2 . GLU B 1 380 ? -2.983 -59.239 27.059 1.00 92.23 ? 353 GLU A OE2 1 ATOM 6050 N N . GLU B 1 381 ? -9.054 -61.521 29.054 1.00 85.79 ? 354 GLU A N 1 ATOM 6051 C CA . GLU B 1 381 ? -10.099 -61.492 30.077 1.00 83.61 ? 354 GLU A CA 1 ATOM 6052 C C . GLU B 1 381 ? -10.717 -62.863 30.292 1.00 75.37 ? 354 GLU A C 1 ATOM 6053 O O . GLU B 1 381 ? -11.065 -63.211 31.416 1.00 69.66 ? 354 GLU A O 1 ATOM 6054 C CB . GLU B 1 381 ? -11.186 -60.474 29.700 1.00 83.03 ? 354 GLU A CB 1 ATOM 6055 C CG . GLU B 1 381 ? -10.689 -59.045 29.720 1.00 84.74 ? 354 GLU A CG 1 ATOM 6056 C CD . GLU B 1 381 ? -10.034 -58.695 31.040 1.00 89.19 ? 354 GLU A CD 1 ATOM 6057 O OE1 . GLU B 1 381 ? -8.851 -58.280 31.032 1.00 81.74 ? 354 GLU A OE1 1 ATOM 6058 O OE2 . GLU B 1 381 ? -10.701 -58.875 32.082 1.00 95.61 ? 354 GLU A OE2 1 ATOM 6059 N N . THR B 1 382 ? -10.872 -63.618 29.207 1.00 73.07 ? 355 THR A N 1 ATOM 6060 C CA . THR B 1 382 ? -11.445 -64.957 29.263 1.00 75.78 ? 355 THR A CA 1 ATOM 6061 C C . THR B 1 382 ? -10.578 -65.895 30.087 1.00 82.97 ? 355 THR A C 1 ATOM 6062 O O . THR B 1 382 ? -11.047 -66.567 30.997 1.00 82.80 ? 355 THR A O 1 ATOM 6063 C CB . THR B 1 382 ? -11.535 -65.576 27.869 1.00 73.66 ? 355 THR A CB 1 ATOM 6064 O OG1 . THR B 1 382 ? -12.161 -64.649 26.983 1.00 80.00 ? 355 THR A OG1 1 ATOM 6065 C CG2 . THR B 1 382 ? -12.344 -66.870 27.909 1.00 73.06 ? 355 THR A CG2 1 ATOM 6066 N N . PHE B 1 383 ? -9.299 -65.929 29.749 1.00 88.29 ? 356 PHE A N 1 ATOM 6067 C CA . PHE B 1 383 ? -8.375 -66.889 30.325 1.00 87.11 ? 356 PHE A CA 1 ATOM 6068 C C . PHE B 1 383 ? -7.547 -66.306 31.459 1.00 91.65 ? 356 PHE A C 1 ATOM 6069 O O . PHE B 1 383 ? -6.719 -67.003 32.041 1.00 96.91 ? 356 PHE A O 1 ATOM 6070 C CB . PHE B 1 383 ? -7.475 -67.425 29.218 1.00 80.00 ? 356 PHE A CB 1 ATOM 6071 C CG . PHE B 1 383 ? -8.232 -68.120 28.141 1.00 71.06 ? 356 PHE A CG 1 ATOM 6072 C CD1 . PHE B 1 383 ? -8.947 -69.260 28.438 1.00 67.06 ? 356 PHE A CD1 1 ATOM 6073 C CD2 . PHE B 1 383 ? -8.260 -67.628 26.842 1.00 77.87 ? 356 PHE A CD2 1 ATOM 6074 C CE1 . PHE B 1 383 ? -9.660 -69.929 27.458 1.00 66.12 ? 356 PHE A CE1 1 ATOM 6075 C CE2 . PHE B 1 383 ? -8.978 -68.292 25.854 1.00 73.91 ? 356 PHE A CE2 1 ATOM 6076 C CZ . PHE B 1 383 ? -9.675 -69.444 26.164 1.00 70.21 ? 356 PHE A CZ 1 ATOM 6077 N N . ASN B 1 384 ? -7.768 -65.032 31.771 1.00 99.12 ? 357 ASN A N 1 ATOM 6078 C CA . ASN B 1 384 ? -7.188 -64.422 32.960 1.00 101.47 ? 357 ASN A CA 1 ATOM 6079 C C . ASN B 1 384 ? -5.657 -64.400 32.874 1.00 102.68 ? 357 ASN A C 1 ATOM 6080 O O . ASN B 1 384 ? -4.969 -64.743 33.833 1.00 105.98 ? 357 ASN A O 1 ATOM 6081 C CB . ASN B 1 384 ? -7.672 -65.199 34.191 1.00 104.08 ? 357 ASN A CB 1 ATOM 6082 C CG . ASN B 1 384 ? -8.067 -64.296 35.336 1.00 111.74 ? 357 ASN A CG 1 ATOM 6083 O OD1 . ASN B 1 384 ? -9.200 -64.355 35.814 1.00 118.15 ? 357 ASN A OD1 1 ATOM 6084 N ND2 . ASN B 1 384 ? -7.141 -63.454 35.781 1.00 110.36 ? 357 ASN A ND2 1 ATOM 6085 N N . CYS B 1 385 ? -5.133 -63.996 31.715 1.00 106.62 ? 358 CYS A N 1 ATOM 6086 C CA . CYS B 1 385 ? -3.696 -64.104 31.413 1.00 108.10 ? 358 CYS A CA 1 ATOM 6087 C C . CYS B 1 385 ? -3.140 -62.855 30.689 1.00 109.07 ? 358 CYS A C 1 ATOM 6088 O O . CYS B 1 385 ? -3.847 -61.863 30.556 1.00 115.84 ? 358 CYS A O 1 ATOM 6089 C CB . CYS B 1 385 ? -3.411 -65.421 30.652 1.00 108.96 ? 358 CYS A CB 1 ATOM 6090 S SG . CYS B 1 385 ? -4.199 -65.688 29.040 1.00 108.06 ? 358 CYS A SG 1 ATOM 6091 N N . HIS B 1 386 ? -1.869 -62.889 30.281 1.00 117.79 ? 359 HIS A N 1 ATOM 6092 C CA . HIS B 1 386 ? -1.212 -61.765 29.582 1.00 127.09 ? 359 HIS A CA 1 ATOM 6093 C C . HIS B 1 386 ? -0.596 -62.270 28.252 1.00 119.65 ? 359 HIS A C 1 ATOM 6094 O O . HIS B 1 386 ? -0.339 -63.463 28.101 1.00 119.97 ? 359 HIS A O 1 ATOM 6095 C CB . HIS B 1 386 ? -0.166 -61.119 30.515 1.00 136.05 ? 359 HIS A CB 1 ATOM 6096 C CG . HIS B 1 386 ? 0.438 -59.850 29.986 1.00 159.50 ? 359 HIS A CG 1 ATOM 6097 N ND1 . HIS B 1 386 ? -0.189 -58.623 30.074 1.00 165.21 ? 359 HIS A ND1 1 ATOM 6098 C CD2 . HIS B 1 386 ? 1.628 -59.618 29.377 1.00 167.78 ? 359 HIS A CD2 1 ATOM 6099 C CE1 . HIS B 1 386 ? 0.581 -57.695 29.531 1.00 162.59 ? 359 HIS A CE1 1 ATOM 6100 N NE2 . HIS B 1 386 ? 1.690 -58.272 29.102 1.00 165.43 ? 359 HIS A NE2 1 ATOM 6101 N N . LEU B 1 387 ? -0.374 -61.377 27.291 1.00 110.70 ? 360 LEU A N 1 ATOM 6102 C CA . LEU B 1 387 ? 0.007 -61.786 25.944 1.00 108.74 ? 360 LEU A CA 1 ATOM 6103 C C . LEU B 1 387 ? 1.422 -61.340 25.527 1.00 120.11 ? 360 LEU A C 1 ATOM 6104 O O . LEU B 1 387 ? 1.780 -60.168 25.660 1.00 119.41 ? 360 LEU A O 1 ATOM 6105 C CB . LEU B 1 387 ? -1.033 -61.251 24.962 1.00 102.34 ? 360 LEU A CB 1 ATOM 6106 C CG . LEU B 1 387 ? -1.591 -62.270 23.979 1.00 106.01 ? 360 LEU A CG 1 ATOM 6107 C CD1 . LEU B 1 387 ? -2.196 -63.477 24.685 1.00 106.45 ? 360 LEU A CD1 1 ATOM 6108 C CD2 . LEU B 1 387 ? -2.630 -61.593 23.108 1.00 105.48 ? 360 LEU A CD2 1 ATOM 6109 N N . GLN B 1 388 ? 2.214 -62.287 25.015 1.00 127.84 ? 361 GLN A N 1 ATOM 6110 C CA . GLN B 1 388 ? 3.569 -62.015 24.513 1.00 122.54 ? 361 GLN A CA 1 ATOM 6111 C C . GLN B 1 388 ? 3.512 -61.730 23.021 1.00 114.10 ? 361 GLN A C 1 ATOM 6112 O O . GLN B 1 388 ? 3.696 -60.592 22.603 1.00 117.11 ? 361 GLN A O 1 ATOM 6113 C CB . GLN B 1 388 ? 4.506 -63.205 24.777 1.00 114.85 ? 361 GLN A CB 1 ATOM 6114 N N . ARG B 1 419 ? -1.097 -62.752 37.112 1.00 88.56 ? 392 ARG A N 1 ATOM 6115 C CA . ARG B 1 419 ? -0.911 -62.290 35.730 1.00 102.51 ? 392 ARG A CA 1 ATOM 6116 C C . ARG B 1 419 ? 0.002 -63.194 34.854 1.00 102.61 ? 392 ARG A C 1 ATOM 6117 O O . ARG B 1 419 ? 0.906 -62.687 34.182 1.00 108.03 ? 392 ARG A O 1 ATOM 6118 C CB . ARG B 1 419 ? -0.379 -60.844 35.728 1.00 100.04 ? 392 ARG A CB 1 ATOM 6119 N N . PRO B 1 420 ? -0.250 -64.524 34.834 1.00 101.50 ? 393 PRO A N 1 ATOM 6120 C CA . PRO B 1 420 ? 0.510 -65.482 33.995 1.00 101.60 ? 393 PRO A CA 1 ATOM 6121 C C . PRO B 1 420 ? 0.385 -65.226 32.489 1.00 106.66 ? 393 PRO A C 1 ATOM 6122 O O . PRO B 1 420 ? -0.626 -64.695 32.057 1.00 118.75 ? 393 PRO A O 1 ATOM 6123 C CB . PRO B 1 420 ? -0.118 -66.835 34.341 1.00 97.50 ? 393 PRO A CB 1 ATOM 6124 C CG . PRO B 1 420 ? -1.443 -66.518 34.932 1.00 100.03 ? 393 PRO A CG 1 ATOM 6125 C CD . PRO B 1 420 ? -1.278 -65.207 35.639 1.00 102.11 ? 393 PRO A CD 1 ATOM 6126 N N . LEU B 1 421 ? 1.399 -65.595 31.701 1.00 109.51 ? 394 LEU A N 1 ATOM 6127 C CA . LEU B 1 421 ? 1.378 -65.358 30.244 1.00 107.33 ? 394 LEU A CA 1 ATOM 6128 C C . LEU B 1 421 ? 0.564 -66.458 29.546 1.00 109.06 ? 394 LEU A C 1 ATOM 6129 O O . LEU B 1 421 ? 0.479 -67.586 30.046 1.00 100.72 ? 394 LEU A O 1 ATOM 6130 C CB . LEU B 1 421 ? 2.803 -65.259 29.664 1.00 97.77 ? 394 LEU A CB 1 ATOM 6131 N N . CYS B 1 422 ? -0.041 -66.114 28.405 1.00 113.35 ? 395 CYS A N 1 ATOM 6132 C CA . CYS B 1 422 ? -0.962 -67.016 27.698 1.00 123.33 ? 395 CYS A CA 1 ATOM 6133 C C . CYS B 1 422 ? -0.227 -67.903 26.708 1.00 125.17 ? 395 CYS A C 1 ATOM 6134 O O . CYS B 1 422 ? 0.637 -67.431 25.968 1.00 118.47 ? 395 CYS A O 1 ATOM 6135 C CB . CYS B 1 422 ? -2.039 -66.243 26.911 1.00 126.75 ? 395 CYS A CB 1 ATOM 6136 S SG . CYS B 1 422 ? -2.865 -64.857 27.736 1.00 128.67 ? 395 CYS A SG 1 ATOM 6137 N N . THR B 1 423 ? -0.629 -69.173 26.658 1.00 132.66 ? 396 THR A N 1 ATOM 6138 C CA . THR B 1 423 ? -0.054 -70.146 25.716 1.00 126.68 ? 396 THR A CA 1 ATOM 6139 C C . THR B 1 423 ? -0.437 -69.794 24.264 1.00 132.52 ? 396 THR A C 1 ATOM 6140 O O . THR B 1 423 ? 0.314 -70.085 23.327 1.00 135.36 ? 396 THR A O 1 ATOM 6141 C CB . THR B 1 423 ? -0.457 -71.628 26.037 1.00 118.99 ? 396 THR A CB 1 ATOM 6142 O OG1 . THR B 1 423 ? -1.668 -71.994 25.356 1.00 109.84 ? 396 THR A OG1 1 ATOM 6143 C CG2 . THR B 1 423 ? -0.616 -71.877 27.552 1.00 111.63 ? 396 THR A CG2 1 ATOM 6144 N N . GLY B 1 424 ? -1.601 -69.165 24.087 1.00 134.18 ? 397 GLY A N 1 ATOM 6145 C CA . GLY B 1 424 ? -2.135 -68.877 22.757 1.00 132.06 ? 397 GLY A CA 1 ATOM 6146 C C . GLY B 1 424 ? -2.772 -70.096 22.111 1.00 132.83 ? 397 GLY A C 1 ATOM 6147 O O . GLY B 1 424 ? -3.145 -70.053 20.938 1.00 129.35 ? 397 GLY A O 1 ATOM 6148 N N . ASP B 1 425 ? -2.890 -71.184 22.877 1.00 132.97 ? 398 ASP A N 1 ATOM 6149 C CA . ASP B 1 425 ? -3.450 -72.442 22.388 1.00 132.12 ? 398 ASP A CA 1 ATOM 6150 C C . ASP B 1 425 ? -4.793 -72.761 23.037 1.00 120.39 ? 398 ASP A C 1 ATOM 6151 O O . ASP B 1 425 ? -5.565 -73.555 22.496 1.00 118.87 ? 398 ASP A O 1 ATOM 6152 C CB . ASP B 1 425 ? -2.471 -73.603 22.661 1.00 134.67 ? 398 ASP A CB 1 ATOM 6153 C CG . ASP B 1 425 ? -1.123 -73.435 21.946 1.00 136.43 ? 398 ASP A CG 1 ATOM 6154 O OD1 . ASP B 1 425 ? -1.024 -72.644 20.982 1.00 144.29 ? 398 ASP A OD1 1 ATOM 6155 O OD2 . ASP B 1 425 ? -0.154 -74.111 22.349 1.00 130.41 ? 398 ASP A OD2 1 ATOM 6156 N N . GLU B 1 426 ? -5.074 -72.121 24.175 1.00 113.55 ? 399 GLU A N 1 ATOM 6157 C CA . GLU B 1 426 ? -6.158 -72.545 25.097 1.00 104.76 ? 399 GLU A CA 1 ATOM 6158 C C . GLU B 1 426 ? -7.568 -72.548 24.492 1.00 93.77 ? 399 GLU A C 1 ATOM 6159 O O . GLU B 1 426 ? -7.812 -71.968 23.431 1.00 92.53 ? 399 GLU A O 1 ATOM 6160 C CB . GLU B 1 426 ? -6.133 -71.753 26.432 1.00 101.98 ? 399 GLU A CB 1 ATOM 6161 C CG . GLU B 1 426 ? -5.802 -70.260 26.339 1.00 102.65 ? 399 GLU A CG 1 ATOM 6162 C CD . GLU B 1 426 ? -4.377 -69.900 26.768 1.00 99.38 ? 399 GLU A CD 1 ATOM 6163 O OE1 . GLU B 1 426 ? -3.973 -70.316 27.886 1.00 93.71 ? 399 GLU A OE1 1 ATOM 6164 O OE2 . GLU B 1 426 ? -3.682 -69.174 25.999 1.00 86.96 ? 399 GLU A OE2 1 ATOM 6165 N N . ASN B 1 427 ? -8.481 -73.232 25.174 1.00 89.91 ? 400 ASN A N 1 ATOM 6166 C CA . ASN B 1 427 ? -9.800 -73.533 24.615 1.00 98.92 ? 400 ASN A CA 1 ATOM 6167 C C . ASN B 1 427 ? -10.910 -72.605 25.144 1.00 103.69 ? 400 ASN A C 1 ATOM 6168 O O . ASN B 1 427 ? -11.174 -72.543 26.353 1.00 94.47 ? 400 ASN A O 1 ATOM 6169 C CB . ASN B 1 427 ? -10.159 -75.001 24.889 1.00 97.71 ? 400 ASN A CB 1 ATOM 6170 C CG . ASN B 1 427 ? -11.221 -75.537 23.942 1.00 99.11 ? 400 ASN A CG 1 ATOM 6171 O OD1 . ASN B 1 427 ? -12.373 -75.752 24.333 1.00 104.29 ? 400 ASN A OD1 1 ATOM 6172 N ND2 . ASN B 1 427 ? -10.834 -75.762 22.691 1.00 103.63 ? 400 ASN A ND2 1 ATOM 6173 N N . ILE B 1 428 ? -11.550 -71.885 24.226 1.00 101.73 ? 401 ILE A N 1 ATOM 6174 C CA . ILE B 1 428 ? -12.727 -71.074 24.543 1.00 104.27 ? 401 ILE A CA 1 ATOM 6175 C C . ILE B 1 428 ? -13.850 -71.878 25.195 1.00 98.30 ? 401 ILE A C 1 ATOM 6176 O O . ILE B 1 428 ? -14.521 -71.375 26.097 1.00 91.60 ? 401 ILE A O 1 ATOM 6177 C CB . ILE B 1 428 ? -13.285 -70.401 23.273 1.00 110.08 ? 401 ILE A CB 1 ATOM 6178 C CG1 . ILE B 1 428 ? -12.461 -69.156 22.943 1.00 114.16 ? 401 ILE A CG1 1 ATOM 6179 C CG2 . ILE B 1 428 ? -14.757 -70.031 23.440 1.00 111.59 ? 401 ILE A CG2 1 ATOM 6180 C CD1 . ILE B 1 428 ? -12.559 -68.725 21.494 1.00 117.66 ? 401 ILE A CD1 1 ATOM 6181 N N . SER B 1 429 ? -14.052 -73.113 24.735 1.00 94.75 ? 402 SER A N 1 ATOM 6182 C CA . SER B 1 429 ? -15.135 -73.958 25.234 1.00 89.14 ? 402 SER A CA 1 ATOM 6183 C C . SER B 1 429 ? -14.885 -74.500 26.663 1.00 90.63 ? 402 SER A C 1 ATOM 6184 O O . SER B 1 429 ? -15.726 -75.249 27.181 1.00 93.86 ? 402 SER A O 1 ATOM 6185 C CB . SER B 1 429 ? -15.427 -75.093 24.239 1.00 77.41 ? 402 SER A CB 1 ATOM 6186 N N . SER B 1 430 ? -13.767 -74.110 27.299 1.00 83.89 ? 403 SER A N 1 ATOM 6187 C CA . SER B 1 430 ? -13.487 -74.474 28.705 1.00 91.96 ? 403 SER A CA 1 ATOM 6188 C C . SER B 1 430 ? -14.069 -73.519 29.758 1.00 101.28 ? 403 SER A C 1 ATOM 6189 O O . SER B 1 430 ? -14.609 -73.984 30.775 1.00 91.42 ? 403 SER A O 1 ATOM 6190 C CB . SER B 1 430 ? -11.975 -74.630 28.953 1.00 92.14 ? 403 SER A CB 1 ATOM 6191 O OG . SER B 1 430 ? -11.243 -73.472 28.598 1.00 89.10 ? 403 SER A OG 1 ATOM 6192 N N . VAL B 1 431 ? -13.945 -72.203 29.516 1.00 112.76 ? 404 VAL A N 1 ATOM 6193 C CA . VAL B 1 431 ? -14.368 -71.149 30.476 1.00 114.21 ? 404 VAL A CA 1 ATOM 6194 C C . VAL B 1 431 ? -15.830 -70.718 30.235 1.00 109.22 ? 404 VAL A C 1 ATOM 6195 O O . VAL B 1 431 ? -16.232 -70.491 29.091 1.00 111.86 ? 404 VAL A O 1 ATOM 6196 C CB . VAL B 1 431 ? -13.462 -69.884 30.405 1.00 119.72 ? 404 VAL A CB 1 ATOM 6197 C CG1 . VAL B 1 431 ? -13.668 -68.997 31.633 1.00 121.59 ? 404 VAL A CG1 1 ATOM 6198 C CG2 . VAL B 1 431 ? -11.990 -70.258 30.275 1.00 119.01 ? 404 VAL A CG2 1 ATOM 6199 N N . GLU B 1 432 ? -16.620 -70.610 31.307 1.00 96.25 ? 405 GLU A N 1 ATOM 6200 C CA . GLU B 1 432 ? -18.023 -70.210 31.187 1.00 95.32 ? 405 GLU A CA 1 ATOM 6201 C C . GLU B 1 432 ? -18.126 -68.676 31.270 1.00 92.49 ? 405 GLU A C 1 ATOM 6202 O O . GLU B 1 432 ? -17.894 -68.084 32.341 1.00 79.63 ? 405 GLU A O 1 ATOM 6203 C CB . GLU B 1 432 ? -18.883 -70.879 32.272 1.00 87.43 ? 405 GLU A CB 1 ATOM 6204 N N . THR B 1 433 ? -18.426 -68.054 30.119 1.00 82.27 ? 406 THR A N 1 ATOM 6205 C CA . THR B 1 433 ? -18.763 -66.624 30.020 1.00 72.64 ? 406 THR A CA 1 ATOM 6206 C C . THR B 1 433 ? -19.916 -66.430 29.027 1.00 71.67 ? 406 THR A C 1 ATOM 6207 O O . THR B 1 433 ? -20.131 -67.274 28.167 1.00 82.47 ? 406 THR A O 1 ATOM 6208 C CB . THR B 1 433 ? -17.570 -65.751 29.541 1.00 70.58 ? 406 THR A CB 1 ATOM 6209 O OG1 . THR B 1 433 ? -17.373 -65.910 28.128 1.00 69.77 ? 406 THR A OG1 1 ATOM 6210 C CG2 . THR B 1 433 ? -16.292 -66.074 30.303 1.00 68.89 ? 406 THR A CG2 1 ATOM 6211 N N . PRO B 1 434 ? -20.639 -65.295 29.114 1.00 72.14 ? 407 PRO A N 1 ATOM 6212 C CA . PRO B 1 434 ? -21.767 -65.010 28.218 1.00 67.59 ? 407 PRO A CA 1 ATOM 6213 C C . PRO B 1 434 ? -21.449 -65.044 26.734 1.00 71.90 ? 407 PRO A C 1 ATOM 6214 O O . PRO B 1 434 ? -22.368 -65.138 25.924 1.00 78.97 ? 407 PRO A O 1 ATOM 6215 C CB . PRO B 1 434 ? -22.156 -63.588 28.601 1.00 68.95 ? 407 PRO A CB 1 ATOM 6216 C CG . PRO B 1 434 ? -21.710 -63.436 30.014 1.00 66.99 ? 407 PRO A CG 1 ATOM 6217 C CD . PRO B 1 434 ? -20.437 -64.205 30.092 1.00 70.73 ? 407 PRO A CD 1 ATOM 6218 N N . TYR B 1 435 ? -20.173 -64.944 26.377 1.00 70.46 ? 408 TYR A N 1 ATOM 6219 C CA . TYR B 1 435 ? -19.749 -65.009 24.979 1.00 71.85 ? 408 TYR A CA 1 ATOM 6220 C C . TYR B 1 435 ? -20.285 -66.215 24.259 1.00 75.62 ? 408 TYR A C 1 ATOM 6221 O O . TYR B 1 435 ? -20.697 -66.124 23.113 1.00 79.39 ? 408 TYR A O 1 ATOM 6222 C CB . TYR B 1 435 ? -18.227 -65.059 24.885 1.00 71.52 ? 408 TYR A CB 1 ATOM 6223 C CG . TYR B 1 435 ? -17.716 -65.114 23.467 1.00 71.27 ? 408 TYR A CG 1 ATOM 6224 C CD1 . TYR B 1 435 ? -18.021 -64.107 22.580 1.00 77.41 ? 408 TYR A CD1 1 ATOM 6225 C CD2 . TYR B 1 435 ? -16.914 -66.160 23.013 1.00 73.39 ? 408 TYR A CD2 1 ATOM 6226 C CE1 . TYR B 1 435 ? -17.560 -64.133 21.279 1.00 76.48 ? 408 TYR A CE1 1 ATOM 6227 C CE2 . TYR B 1 435 ? -16.437 -66.186 21.711 1.00 68.93 ? 408 TYR A CE2 1 ATOM 6228 C CZ . TYR B 1 435 ? -16.767 -65.164 20.852 1.00 69.09 ? 408 TYR A CZ 1 ATOM 6229 O OH . TYR B 1 435 ? -16.342 -65.118 19.556 1.00 63.43 ? 408 TYR A OH 1 ATOM 6230 N N . ILE B 1 436 ? -20.227 -67.359 24.927 1.00 88.47 ? 409 ILE A N 1 ATOM 6231 C CA . ILE B 1 436 ? -20.729 -68.609 24.361 1.00 93.95 ? 409 ILE A CA 1 ATOM 6232 C C . ILE B 1 436 ? -21.835 -69.214 25.209 1.00 83.94 ? 409 ILE A C 1 ATOM 6233 O O . ILE B 1 436 ? -22.691 -69.907 24.682 1.00 83.08 ? 409 ILE A O 1 ATOM 6234 C CB . ILE B 1 436 ? -19.569 -69.626 24.141 1.00 106.95 ? 409 ILE A CB 1 ATOM 6235 C CG1 . ILE B 1 436 ? -19.528 -70.067 22.685 1.00 109.30 ? 409 ILE A CG1 1 ATOM 6236 C CG2 . ILE B 1 436 ? -19.645 -70.840 25.074 1.00 111.91 ? 409 ILE A CG2 1 ATOM 6237 C CD1 . ILE B 1 436 ? -19.042 -68.976 21.757 1.00 110.65 ? 409 ILE A CD1 1 ATOM 6238 N N . ASP B 1 437 ? -21.810 -68.968 26.515 1.00 80.98 ? 410 ASP A N 1 ATOM 6239 C CA . ASP B 1 437 ? -22.813 -69.515 27.412 1.00 89.36 ? 410 ASP A CA 1 ATOM 6240 C C . ASP B 1 437 ? -24.126 -68.755 27.245 1.00 87.58 ? 410 ASP A C 1 ATOM 6241 O O . ASP B 1 437 ? -24.431 -67.824 27.989 1.00 99.42 ? 410 ASP A O 1 ATOM 6242 C CB . ASP B 1 437 ? -22.321 -69.449 28.868 1.00 95.50 ? 410 ASP A CB 1 ATOM 6243 C CG . ASP B 1 437 ? -23.244 -70.176 29.839 1.00 95.66 ? 410 ASP A CG 1 ATOM 6244 O OD1 . ASP B 1 437 ? -24.091 -70.965 29.360 1.00 96.37 ? 410 ASP A OD1 1 ATOM 6245 O OD2 . ASP B 1 437 ? -23.114 -69.964 31.073 1.00 95.03 ? 410 ASP A OD2 1 ATOM 6246 N N . TYR B 1 438 ? -24.884 -69.153 26.235 1.00 84.34 ? 411 TYR A N 1 ATOM 6247 C CA . TYR B 1 438 ? -26.205 -68.590 25.955 1.00 79.64 ? 411 TYR A CA 1 ATOM 6248 C C . TYR B 1 438 ? -26.982 -69.692 25.273 1.00 82.86 ? 411 TYR A C 1 ATOM 6249 O O . TYR B 1 438 ? -26.383 -70.564 24.612 1.00 78.65 ? 411 TYR A O 1 ATOM 6250 C CB . TYR B 1 438 ? -26.120 -67.417 24.980 1.00 74.99 ? 411 TYR A CB 1 ATOM 6251 C CG . TYR B 1 438 ? -25.684 -67.837 23.568 1.00 71.73 ? 411 TYR A CG 1 ATOM 6252 C CD1 . TYR B 1 438 ? -26.604 -68.387 22.647 1.00 65.85 ? 411 TYR A CD1 1 ATOM 6253 C CD2 . TYR B 1 438 ? -24.350 -67.697 23.159 1.00 65.58 ? 411 TYR A CD2 1 ATOM 6254 C CE1 . TYR B 1 438 ? -26.208 -68.758 21.363 1.00 63.48 ? 411 TYR A CE1 1 ATOM 6255 C CE2 . TYR B 1 438 ? -23.947 -68.071 21.882 1.00 63.99 ? 411 TYR A CE2 1 ATOM 6256 C CZ . TYR B 1 438 ? -24.869 -68.602 20.985 1.00 62.48 ? 411 TYR A CZ 1 ATOM 6257 O OH . TYR B 1 438 ? -24.441 -68.988 19.723 1.00 57.28 ? 411 TYR A OH 1 ATOM 6258 N N . THR B 1 439 ? -28.303 -69.621 25.394 1.00 82.67 ? 412 THR A N 1 ATOM 6259 C CA . THR B 1 439 ? -29.195 -70.548 24.706 1.00 83.47 ? 412 THR A CA 1 ATOM 6260 C C . THR B 1 439 ? -29.848 -69.873 23.505 1.00 78.55 ? 412 THR A C 1 ATOM 6261 O O . THR B 1 439 ? -29.797 -70.416 22.430 1.00 77.55 ? 412 THR A O 1 ATOM 6262 C CB . THR B 1 439 ? -30.277 -71.177 25.621 1.00 91.06 ? 412 THR A CB 1 ATOM 6263 O OG1 . THR B 1 439 ? -31.558 -70.998 25.005 1.00 97.89 ? 412 THR A OG1 1 ATOM 6264 C CG2 . THR B 1 439 ? -30.293 -70.580 27.072 1.00 88.22 ? 412 THR A CG2 1 ATOM 6265 N N . HIS B 1 440 ? -30.443 -68.693 23.683 1.00 79.88 ? 413 HIS A N 1 ATOM 6266 C CA . HIS B 1 440 ? -31.119 -67.991 22.575 1.00 80.15 ? 413 HIS A CA 1 ATOM 6267 C C . HIS B 1 440 ? -30.370 -66.763 22.048 1.00 72.13 ? 413 HIS A C 1 ATOM 6268 O O . HIS B 1 440 ? -29.739 -66.044 22.798 1.00 71.81 ? 413 HIS A O 1 ATOM 6269 C CB . HIS B 1 440 ? -32.493 -67.489 22.998 1.00 83.92 ? 413 HIS A CB 1 ATOM 6270 C CG . HIS B 1 440 ? -33.352 -68.514 23.651 1.00 92.96 ? 413 HIS A CG 1 ATOM 6271 N ND1 . HIS B 1 440 ? -34.224 -69.312 22.942 1.00 95.88 ? 413 HIS A ND1 1 ATOM 6272 C CD2 . HIS B 1 440 ? -33.514 -68.837 24.956 1.00 90.60 ? 413 HIS A CD2 1 ATOM 6273 C CE1 . HIS B 1 440 ? -34.869 -70.100 23.783 1.00 99.15 ? 413 HIS A CE1 1 ATOM 6274 N NE2 . HIS B 1 440 ? -34.458 -69.830 25.010 1.00 92.97 ? 413 HIS A NE2 1 ATOM 6275 N N . LEU B 1 441 ? -30.506 -66.503 20.754 1.00 71.43 ? 414 LEU A N 1 ATOM 6276 C CA . LEU B 1 441 ? -29.992 -65.290 20.145 1.00 68.22 ? 414 LEU A CA 1 ATOM 6277 C C . LEU B 1 441 ? -31.155 -64.305 19.945 1.00 68.31 ? 414 LEU A C 1 ATOM 6278 O O . LEU B 1 441 ? -32.056 -64.542 19.126 1.00 59.41 ? 414 LEU A O 1 ATOM 6279 C CB . LEU B 1 441 ? -29.321 -65.599 18.799 1.00 72.84 ? 414 LEU A CB 1 ATOM 6280 C CG . LEU B 1 441 ? -28.066 -66.485 18.743 1.00 70.23 ? 414 LEU A CG 1 ATOM 6281 C CD1 . LEU B 1 441 ? -27.606 -66.603 17.295 1.00 76.87 ? 414 LEU A CD1 1 ATOM 6282 C CD2 . LEU B 1 441 ? -26.932 -65.922 19.583 1.00 74.31 ? 414 LEU A CD2 1 ATOM 6283 N N . ARG B 1 442 ? -31.115 -63.209 20.712 1.00 71.24 ? 415 ARG A N 1 ATOM 6284 C CA . ARG B 1 442 ? -32.123 -62.148 20.698 1.00 62.95 ? 415 ARG A CA 1 ATOM 6285 C C . ARG B 1 442 ? -31.551 -60.806 20.201 1.00 62.68 ? 415 ARG A C 1 ATOM 6286 O O . ARG B 1 442 ? -31.787 -60.424 19.042 1.00 63.11 ? 415 ARG A O 1 ATOM 6287 C CB . ARG B 1 442 ? -32.743 -62.037 22.080 1.00 63.19 ? 415 ARG A CB 1 ATOM 6288 C CG . ARG B 1 442 ? -33.387 -63.338 22.521 1.00 64.50 ? 415 ARG A CG 1 ATOM 6289 C CD . ARG B 1 442 ? -34.382 -63.143 23.646 1.00 68.61 ? 415 ARG A CD 1 ATOM 6290 N NE . ARG B 1 442 ? -34.330 -64.264 24.592 1.00 75.66 ? 415 ARG A NE 1 ATOM 6291 C CZ . ARG B 1 442 ? -35.276 -65.188 24.778 1.00 80.24 ? 415 ARG A CZ 1 ATOM 6292 N NH1 . ARG B 1 442 ? -36.427 -65.175 24.105 1.00 80.45 ? 415 ARG A NH1 1 ATOM 6293 N NH2 . ARG B 1 442 ? -35.066 -66.146 25.671 1.00 86.61 ? 415 ARG A NH2 1 ATOM 6294 N N . ILE B 1 443 ? -30.799 -60.083 21.029 1.00 57.71 ? 416 ILE A N 1 ATOM 6295 C CA . ILE B 1 443 ? -30.151 -58.860 20.527 1.00 54.46 ? 416 ILE A CA 1 ATOM 6296 C C . ILE B 1 443 ? -29.205 -59.212 19.374 1.00 53.96 ? 416 ILE A C 1 ATOM 6297 O O . ILE B 1 443 ? -29.171 -58.500 18.382 1.00 52.54 ? 416 ILE A O 1 ATOM 6298 C CB . ILE B 1 443 ? -29.422 -58.068 21.638 1.00 56.62 ? 416 ILE A CB 1 ATOM 6299 C CG1 . ILE B 1 443 ? -30.404 -57.635 22.742 1.00 55.92 ? 416 ILE A CG1 1 ATOM 6300 C CG2 . ILE B 1 443 ? -28.710 -56.833 21.095 1.00 56.34 ? 416 ILE A CG2 1 ATOM 6301 C CD1 . ILE B 1 443 ? -31.617 -56.899 22.252 1.00 52.47 ? 416 ILE A CD1 1 ATOM 6302 N N . SER B 1 444 ? -28.464 -60.318 19.495 1.00 60.53 ? 417 SER A N 1 ATOM 6303 C CA . SER B 1 444 ? -27.522 -60.779 18.442 1.00 56.66 ? 417 SER A CA 1 ATOM 6304 C C . SER B 1 444 ? -28.279 -60.925 17.126 1.00 53.64 ? 417 SER A C 1 ATOM 6305 O O . SER B 1 444 ? -27.817 -60.530 16.054 1.00 53.63 ? 417 SER A O 1 ATOM 6306 C CB . SER B 1 444 ? -26.888 -62.148 18.797 1.00 62.29 ? 417 SER A CB 1 ATOM 6307 O OG . SER B 1 444 ? -26.050 -62.152 19.962 1.00 52.83 ? 417 SER A OG 1 ATOM 6308 N N . TYR B 1 445 ? -29.473 -61.477 17.190 1.00 52.57 ? 418 TYR A N 1 ATOM 6309 C CA . TYR B 1 445 ? -30.266 -61.557 15.975 1.00 54.52 ? 418 TYR A CA 1 ATOM 6310 C C . TYR B 1 445 ? -30.645 -60.183 15.427 1.00 58.68 ? 418 TYR A C 1 ATOM 6311 O O . TYR B 1 445 ? -30.667 -59.984 14.220 1.00 61.95 ? 418 TYR A O 1 ATOM 6312 C CB . TYR B 1 445 ? -31.510 -62.406 16.190 1.00 55.21 ? 418 TYR A CB 1 ATOM 6313 C CG . TYR B 1 445 ? -32.219 -62.715 14.894 1.00 61.96 ? 418 TYR A CG 1 ATOM 6314 C CD1 . TYR B 1 445 ? -31.652 -63.581 13.959 1.00 64.58 ? 418 TYR A CD1 1 ATOM 6315 C CD2 . TYR B 1 445 ? -33.444 -62.137 14.593 1.00 60.75 ? 418 TYR A CD2 1 ATOM 6316 C CE1 . TYR B 1 445 ? -32.297 -63.872 12.777 1.00 69.18 ? 418 TYR A CE1 1 ATOM 6317 C CE2 . TYR B 1 445 ? -34.093 -62.428 13.416 1.00 62.84 ? 418 TYR A CE2 1 ATOM 6318 C CZ . TYR B 1 445 ? -33.522 -63.296 12.513 1.00 67.53 ? 418 TYR A CZ 1 ATOM 6319 O OH . TYR B 1 445 ? -34.173 -63.582 11.332 1.00 70.73 ? 418 TYR A OH 1 ATOM 6320 N N . ASN B 1 446 ? -30.962 -59.237 16.309 1.00 61.21 ? 419 ASN A N 1 ATOM 6321 C CA . ASN B 1 446 ? -31.184 -57.855 15.877 1.00 59.23 ? 419 ASN A CA 1 ATOM 6322 C C . ASN B 1 446 ? -29.990 -57.223 15.121 1.00 55.64 ? 419 ASN A C 1 ATOM 6323 O O . ASN B 1 446 ? -30.161 -56.488 14.123 1.00 50.85 ? 419 ASN A O 1 ATOM 6324 C CB . ASN B 1 446 ? -31.563 -57.010 17.087 1.00 58.83 ? 419 ASN A CB 1 ATOM 6325 C CG . ASN B 1 446 ? -32.938 -57.349 17.608 1.00 59.88 ? 419 ASN A CG 1 ATOM 6326 O OD1 . ASN B 1 446 ? -33.688 -58.071 16.962 1.00 63.88 ? 419 ASN A OD1 1 ATOM 6327 N ND2 . ASN B 1 446 ? -33.282 -56.820 18.775 1.00 63.17 ? 419 ASN A ND2 1 ATOM 6328 N N . VAL B 1 447 ? -28.788 -57.535 15.585 1.00 51.33 ? 420 VAL A N 1 ATOM 6329 C CA . VAL B 1 447 ? -27.575 -56.994 14.984 1.00 52.70 ? 420 VAL A CA 1 ATOM 6330 C C . VAL B 1 447 ? -27.462 -57.499 13.582 1.00 54.91 ? 420 VAL A C 1 ATOM 6331 O O . VAL B 1 447 ? -27.252 -56.727 12.669 1.00 61.68 ? 420 VAL A O 1 ATOM 6332 C CB . VAL B 1 447 ? -26.322 -57.446 15.741 1.00 54.03 ? 420 VAL A CB 1 ATOM 6333 C CG1 . VAL B 1 447 ? -25.081 -56.822 15.117 1.00 54.62 ? 420 VAL A CG1 1 ATOM 6334 C CG2 . VAL B 1 447 ? -26.461 -57.114 17.225 1.00 55.16 ? 420 VAL A CG2 1 ATOM 6335 N N . TYR B 1 448 ? -27.597 -58.818 13.453 1.00 58.38 ? 421 TYR A N 1 ATOM 6336 C CA . TYR B 1 448 ? -27.650 -59.547 12.186 1.00 57.61 ? 421 TYR A CA 1 ATOM 6337 C C . TYR B 1 448 ? -28.639 -58.914 11.259 1.00 53.78 ? 421 TYR A C 1 ATOM 6338 O O . TYR B 1 448 ? -28.294 -58.579 10.150 1.00 63.66 ? 421 TYR A O 1 ATOM 6339 C CB . TYR B 1 448 ? -28.058 -61.003 12.495 1.00 67.91 ? 421 TYR A CB 1 ATOM 6340 C CG . TYR B 1 448 ? -28.055 -61.996 11.356 1.00 72.51 ? 421 TYR A CG 1 ATOM 6341 C CD1 . TYR B 1 448 ? -26.872 -62.620 10.952 1.00 73.91 ? 421 TYR A CD1 1 ATOM 6342 C CD2 . TYR B 1 448 ? -29.251 -62.375 10.734 1.00 77.91 ? 421 TYR A CD2 1 ATOM 6343 C CE1 . TYR B 1 448 ? -26.875 -63.563 9.929 1.00 77.96 ? 421 TYR A CE1 1 ATOM 6344 C CE2 . TYR B 1 448 ? -29.262 -63.305 9.704 1.00 80.59 ? 421 TYR A CE2 1 ATOM 6345 C CZ . TYR B 1 448 ? -28.076 -63.898 9.310 1.00 81.64 ? 421 TYR A CZ 1 ATOM 6346 O OH . TYR B 1 448 ? -28.093 -64.806 8.284 1.00 85.00 ? 421 TYR A OH 1 ATOM 6347 N N . LEU B 1 449 ? -29.868 -58.721 11.720 1.00 56.82 ? 422 LEU A N 1 ATOM 6348 C CA . LEU B 1 449 ? -30.923 -58.156 10.872 1.00 63.08 ? 422 LEU A CA 1 ATOM 6349 C C . LEU B 1 449 ? -30.695 -56.708 10.509 1.00 61.59 ? 422 LEU A C 1 ATOM 6350 O O . LEU B 1 449 ? -31.210 -56.244 9.495 1.00 62.51 ? 422 LEU A O 1 ATOM 6351 C CB . LEU B 1 449 ? -32.286 -58.221 11.550 1.00 68.60 ? 422 LEU A CB 1 ATOM 6352 C CG . LEU B 1 449 ? -33.061 -59.526 11.623 1.00 73.25 ? 422 LEU A CG 1 ATOM 6353 C CD1 . LEU B 1 449 ? -34.434 -59.210 12.200 1.00 70.87 ? 422 LEU A CD1 1 ATOM 6354 C CD2 . LEU B 1 449 ? -33.190 -60.162 10.247 1.00 78.69 ? 422 LEU A CD2 1 ATOM 6355 N N . ALA B 1 450 ? -29.996 -55.977 11.368 1.00 58.59 ? 423 ALA A N 1 ATOM 6356 C CA . ALA B 1 450 ? -29.714 -54.583 11.084 1.00 60.89 ? 423 ALA A CA 1 ATOM 6357 C C . ALA B 1 450 ? -28.776 -54.524 9.886 1.00 60.08 ? 423 ALA A C 1 ATOM 6358 O O . ALA B 1 450 ? -28.975 -53.726 8.980 1.00 62.62 ? 423 ALA A O 1 ATOM 6359 C CB . ALA B 1 450 ? -29.097 -53.894 12.292 1.00 62.55 ? 423 ALA A CB 1 ATOM 6360 N N . VAL B 1 451 ? -27.772 -55.398 9.881 1.00 62.67 ? 424 VAL A N 1 ATOM 6361 C CA . VAL B 1 451 ? -26.786 -55.484 8.796 1.00 61.32 ? 424 VAL A CA 1 ATOM 6362 C C . VAL B 1 451 ? -27.418 -55.924 7.481 1.00 60.25 ? 424 VAL A C 1 ATOM 6363 O O . VAL B 1 451 ? -27.111 -55.355 6.439 1.00 53.60 ? 424 VAL A O 1 ATOM 6364 C CB . VAL B 1 451 ? -25.695 -56.511 9.117 1.00 61.04 ? 424 VAL A CB 1 ATOM 6365 C CG1 . VAL B 1 451 ? -24.824 -56.748 7.906 1.00 65.18 ? 424 VAL A CG1 1 ATOM 6366 C CG2 . VAL B 1 451 ? -24.844 -56.032 10.265 1.00 66.73 ? 424 VAL A CG2 1 ATOM 6367 N N . TYR B 1 452 ? -28.274 -56.947 7.526 1.00 57.31 ? 425 TYR A N 1 ATOM 6368 C CA . TYR B 1 452 ? -28.941 -57.405 6.311 1.00 62.34 ? 425 TYR A CA 1 ATOM 6369 C C . TYR B 1 452 ? -29.909 -56.366 5.781 1.00 61.77 ? 425 TYR A C 1 ATOM 6370 O O . TYR B 1 452 ? -30.155 -56.330 4.599 1.00 60.77 ? 425 TYR A O 1 ATOM 6371 C CB . TYR B 1 452 ? -29.671 -58.735 6.520 1.00 69.75 ? 425 TYR A CB 1 ATOM 6372 C CG . TYR B 1 452 ? -28.875 -59.978 6.133 1.00 70.37 ? 425 TYR A CG 1 ATOM 6373 C CD1 . TYR B 1 452 ? -29.039 -60.568 4.877 1.00 74.05 ? 425 TYR A CD1 1 ATOM 6374 C CD2 . TYR B 1 452 ? -27.989 -60.567 7.022 1.00 67.25 ? 425 TYR A CD2 1 ATOM 6375 C CE1 . TYR B 1 452 ? -28.339 -61.701 4.510 1.00 73.98 ? 425 TYR A CE1 1 ATOM 6376 C CE2 . TYR B 1 452 ? -27.281 -61.700 6.665 1.00 78.29 ? 425 TYR A CE2 1 ATOM 6377 C CZ . TYR B 1 452 ? -27.458 -62.263 5.407 1.00 80.83 ? 425 TYR A CZ 1 ATOM 6378 O OH . TYR B 1 452 ? -26.747 -63.386 5.045 1.00 83.37 ? 425 TYR A OH 1 ATOM 6379 N N . SER B 1 453 ? -30.461 -55.520 6.646 1.00 67.30 ? 426 SER A N 1 ATOM 6380 C CA . SER B 1 453 ? -31.365 -54.467 6.193 1.00 64.97 ? 426 SER A CA 1 ATOM 6381 C C . SER B 1 453 ? -30.575 -53.428 5.415 1.00 65.42 ? 426 SER A C 1 ATOM 6382 O O . SER B 1 453 ? -31.016 -52.927 4.388 1.00 63.87 ? 426 SER A O 1 ATOM 6383 C CB . SER B 1 453 ? -32.107 -53.833 7.375 1.00 66.56 ? 426 SER A CB 1 ATOM 6384 O OG . SER B 1 453 ? -32.935 -54.790 8.044 1.00 64.63 ? 426 SER A OG 1 ATOM 6385 N N . ILE B 1 454 ? -29.388 -53.108 5.895 1.00 64.17 ? 427 ILE A N 1 ATOM 6386 C CA . ILE B 1 454 ? -28.518 -52.234 5.130 1.00 67.73 ? 427 ILE A CA 1 ATOM 6387 C C . ILE B 1 454 ? -28.239 -52.905 3.774 1.00 69.62 ? 427 ILE A C 1 ATOM 6388 O O . ILE B 1 454 ? -28.442 -52.300 2.711 1.00 66.35 ? 427 ILE A O 1 ATOM 6389 C CB . ILE B 1 454 ? -27.232 -51.902 5.919 1.00 60.58 ? 427 ILE A CB 1 ATOM 6390 C CG1 . ILE B 1 454 ? -27.599 -50.976 7.065 1.00 61.86 ? 427 ILE A CG1 1 ATOM 6391 C CG2 . ILE B 1 454 ? -26.209 -51.210 5.035 1.00 63.15 ? 427 ILE A CG2 1 ATOM 6392 C CD1 . ILE B 1 454 ? -26.548 -50.866 8.143 1.00 64.26 ? 427 ILE A CD1 1 ATOM 6393 N N . ALA B 1 455 ? -27.828 -54.170 3.828 1.00 70.19 ? 428 ALA A N 1 ATOM 6394 C CA . ALA B 1 455 ? -27.558 -54.972 2.622 1.00 72.94 ? 428 ALA A CA 1 ATOM 6395 C C . ALA B 1 455 ? -28.713 -55.018 1.599 1.00 66.85 ? 428 ALA A C 1 ATOM 6396 O O . ALA B 1 455 ? -28.545 -54.660 0.442 1.00 69.37 ? 428 ALA A O 1 ATOM 6397 C CB . ALA B 1 455 ? -27.172 -56.387 3.021 1.00 72.84 ? 428 ALA A CB 1 ATOM 6398 N N . HIS B 1 456 ? -29.875 -55.466 2.036 1.00 61.29 ? 429 HIS A N 1 ATOM 6399 C CA . HIS B 1 456 ? -31.051 -55.496 1.193 1.00 63.69 ? 429 HIS A CA 1 ATOM 6400 C C . HIS B 1 456 ? -31.510 -54.150 0.612 1.00 61.24 ? 429 HIS A C 1 ATOM 6401 O O . HIS B 1 456 ? -32.202 -54.135 -0.402 1.00 59.03 ? 429 HIS A O 1 ATOM 6402 C CB . HIS B 1 456 ? -32.212 -56.159 1.939 1.00 69.24 ? 429 HIS A CB 1 ATOM 6403 C CG . HIS B 1 456 ? -32.124 -57.651 1.957 1.00 76.30 ? 429 HIS A CG 1 ATOM 6404 N ND1 . HIS B 1 456 ? -32.427 -58.424 0.854 1.00 83.43 ? 429 HIS A ND1 1 ATOM 6405 C CD2 . HIS B 1 456 ? -31.746 -58.511 2.929 1.00 77.42 ? 429 HIS A CD2 1 ATOM 6406 C CE1 . HIS B 1 456 ? -32.242 -59.697 1.149 1.00 84.62 ? 429 HIS A CE1 1 ATOM 6407 N NE2 . HIS B 1 456 ? -31.824 -59.776 2.401 1.00 88.50 ? 429 HIS A NE2 1 ATOM 6408 N N . ALA B 1 457 ? -31.151 -53.034 1.241 1.00 63.97 ? 430 ALA A N 1 ATOM 6409 C CA . ALA B 1 457 ? -31.476 -51.719 0.687 1.00 66.93 ? 430 ALA A CA 1 ATOM 6410 C C . ALA B 1 457 ? -30.443 -51.345 -0.384 1.00 64.95 ? 430 ALA A C 1 ATOM 6411 O O . ALA B 1 457 ? -30.786 -50.740 -1.400 1.00 68.54 ? 430 ALA A O 1 ATOM 6412 C CB . ALA B 1 457 ? -31.526 -50.660 1.781 1.00 73.07 ? 430 ALA A CB 1 ATOM 6413 N N . LEU B 1 458 ? -29.188 -51.703 -0.152 1.00 62.27 ? 431 LEU A N 1 ATOM 6414 C CA . LEU B 1 458 ? -28.162 -51.632 -1.198 1.00 69.86 ? 431 LEU A CA 1 ATOM 6415 C C . LEU B 1 458 ? -28.478 -52.509 -2.401 1.00 70.92 ? 431 LEU A C 1 ATOM 6416 O O . LEU B 1 458 ? -28.253 -52.096 -3.530 1.00 72.03 ? 431 LEU A O 1 ATOM 6417 C CB . LEU B 1 458 ? -26.793 -52.053 -0.661 1.00 68.01 ? 431 LEU A CB 1 ATOM 6418 C CG . LEU B 1 458 ? -26.111 -51.025 0.235 1.00 69.07 ? 431 LEU A CG 1 ATOM 6419 C CD1 . LEU B 1 458 ? -24.866 -51.639 0.866 1.00 68.26 ? 431 LEU A CD1 1 ATOM 6420 C CD2 . LEU B 1 458 ? -25.785 -49.739 -0.522 1.00 63.97 ? 431 LEU A CD2 1 ATOM 6421 N N . GLN B 1 459 ? -28.977 -53.719 -2.154 1.00 75.65 ? 432 GLN A N 1 ATOM 6422 C CA . GLN B 1 459 ? -29.351 -54.646 -3.235 1.00 81.45 ? 432 GLN A CA 1 ATOM 6423 C C . GLN B 1 459 ? -30.438 -54.009 -4.082 1.00 77.96 ? 432 GLN A C 1 ATOM 6424 O O . GLN B 1 459 ? -30.388 -54.070 -5.298 1.00 84.00 ? 432 GLN A O 1 ATOM 6425 C CB . GLN B 1 459 ? -29.823 -56.003 -2.668 1.00 85.52 ? 432 GLN A CB 1 ATOM 6426 C CG . GLN B 1 459 ? -30.274 -57.059 -3.683 1.00 88.35 ? 432 GLN A CG 1 ATOM 6427 C CD . GLN B 1 459 ? -29.163 -57.598 -4.595 1.00 90.69 ? 432 GLN A CD 1 ATOM 6428 O OE1 . GLN B 1 459 ? -27.960 -57.454 -4.327 1.00 87.11 ? 432 GLN A OE1 1 ATOM 6429 N NE2 . GLN B 1 459 ? -29.576 -58.236 -5.686 1.00 88.39 ? 432 GLN A NE2 1 ATOM 6430 N N . ASP B 1 460 ? -31.399 -53.365 -3.434 1.00 75.63 ? 433 ASP A N 1 ATOM 6431 C CA . ASP B 1 460 ? -32.500 -52.746 -4.145 1.00 72.69 ? 433 ASP A CA 1 ATOM 6432 C C . ASP B 1 460 ? -32.063 -51.567 -4.971 1.00 74.39 ? 433 ASP A C 1 ATOM 6433 O O . ASP B 1 460 ? -32.857 -51.054 -5.746 1.00 73.30 ? 433 ASP A O 1 ATOM 6434 C CB . ASP B 1 460 ? -33.588 -52.320 -3.172 1.00 73.20 ? 433 ASP A CB 1 ATOM 6435 C CG . ASP B 1 460 ? -34.350 -53.496 -2.619 1.00 73.74 ? 433 ASP A CG 1 ATOM 6436 O OD1 . ASP B 1 460 ? -34.141 -54.630 -3.083 1.00 83.34 ? 433 ASP A OD1 1 ATOM 6437 O OD2 . ASP B 1 460 ? -35.176 -53.292 -1.718 1.00 93.67 ? 433 ASP A OD2 1 ATOM 6438 N N . ILE B 1 461 ? -30.818 -51.128 -4.793 1.00 76.94 ? 434 ILE A N 1 ATOM 6439 C CA . ILE B 1 461 ? -30.244 -50.084 -5.630 1.00 83.95 ? 434 ILE A CA 1 ATOM 6440 C C . ILE B 1 461 ? -29.603 -50.704 -6.866 1.00 88.41 ? 434 ILE A C 1 ATOM 6441 O O . ILE B 1 461 ? -29.839 -50.253 -7.989 1.00 89.97 ? 434 ILE A O 1 ATOM 6442 C CB . ILE B 1 461 ? -29.228 -49.228 -4.843 1.00 84.09 ? 434 ILE A CB 1 ATOM 6443 C CG1 . ILE B 1 461 ? -29.980 -48.380 -3.807 1.00 80.64 ? 434 ILE A CG1 1 ATOM 6444 C CG2 . ILE B 1 461 ? -28.424 -48.320 -5.781 1.00 84.39 ? 434 ILE A CG2 1 ATOM 6445 C CD1 . ILE B 1 461 ? -29.092 -47.738 -2.757 1.00 79.57 ? 434 ILE A CD1 1 ATOM 6446 N N . TYR B 1 462 ? -28.791 -51.731 -6.638 1.00 94.69 ? 435 TYR A N 1 ATOM 6447 C CA . TYR B 1 462 ? -28.206 -52.553 -7.701 1.00 100.76 ? 435 TYR A CA 1 ATOM 6448 C C . TYR B 1 462 ? -29.251 -52.914 -8.755 1.00 93.77 ? 435 TYR A C 1 ATOM 6449 O O . TYR B 1 462 ? -29.023 -52.728 -9.944 1.00 94.48 ? 435 TYR A O 1 ATOM 6450 C CB . TYR B 1 462 ? -27.607 -53.839 -7.099 1.00 110.87 ? 435 TYR A CB 1 ATOM 6451 C CG . TYR B 1 462 ? -26.759 -54.679 -8.043 1.00 131.34 ? 435 TYR A CG 1 ATOM 6452 C CD1 . TYR B 1 462 ? -25.492 -54.250 -8.448 1.00 141.15 ? 435 TYR A CD1 1 ATOM 6453 C CD2 . TYR B 1 462 ? -27.208 -55.921 -8.498 1.00 142.14 ? 435 TYR A CD2 1 ATOM 6454 C CE1 . TYR B 1 462 ? -24.712 -55.019 -9.298 1.00 149.85 ? 435 TYR A CE1 1 ATOM 6455 C CE2 . TYR B 1 462 ? -26.434 -56.698 -9.348 1.00 144.96 ? 435 TYR A CE2 1 ATOM 6456 C CZ . TYR B 1 462 ? -25.190 -56.243 -9.747 1.00 150.90 ? 435 TYR A CZ 1 ATOM 6457 O OH . TYR B 1 462 ? -24.421 -57.013 -10.590 1.00 149.77 ? 435 TYR A OH 1 ATOM 6458 N N . THR B 1 463 ? -30.410 -53.378 -8.302 1.00 84.46 ? 436 THR A N 1 ATOM 6459 C CA . THR B 1 463 ? -31.442 -53.924 -9.178 1.00 82.52 ? 436 THR A CA 1 ATOM 6460 C C . THR B 1 463 ? -32.556 -52.921 -9.526 1.00 86.84 ? 436 THR A C 1 ATOM 6461 O O . THR B 1 463 ? -33.666 -53.327 -9.865 1.00 90.19 ? 436 THR A O 1 ATOM 6462 C CB . THR B 1 463 ? -32.113 -55.150 -8.519 1.00 76.22 ? 436 THR A CB 1 ATOM 6463 O OG1 . THR B 1 463 ? -33.019 -54.720 -7.489 1.00 78.78 ? 436 THR A OG1 1 ATOM 6464 C CG2 . THR B 1 463 ? -31.080 -56.085 -7.926 1.00 75.45 ? 436 THR A CG2 1 ATOM 6465 N N . CYS B 1 464 ? -32.284 -51.624 -9.427 1.00 91.87 ? 437 CYS A N 1 ATOM 6466 C CA . CYS B 1 464 ? -33.317 -50.615 -9.695 1.00 96.74 ? 437 CYS A CA 1 ATOM 6467 C C . CYS B 1 464 ? -33.567 -50.537 -11.193 1.00 90.49 ? 437 CYS A C 1 ATOM 6468 O O . CYS B 1 464 ? -32.619 -50.630 -11.981 1.00 88.86 ? 437 CYS A O 1 ATOM 6469 C CB . CYS B 1 464 ? -32.892 -49.233 -9.170 1.00 100.42 ? 437 CYS A CB 1 ATOM 6470 S SG . CYS B 1 464 ? -34.191 -47.969 -9.257 1.00 118.13 ? 437 CYS A SG 1 ATOM 6471 N N . LEU B 1 465 ? -34.829 -50.362 -11.582 1.00 82.38 ? 438 LEU A N 1 ATOM 6472 C CA . LEU B 1 465 ? -35.182 -50.246 -12.998 1.00 86.67 ? 438 LEU A CA 1 ATOM 6473 C C . LEU B 1 465 ? -35.581 -48.828 -13.351 1.00 89.50 ? 438 LEU A C 1 ATOM 6474 O O . LEU B 1 465 ? -36.597 -48.326 -12.866 1.00 89.51 ? 438 LEU A O 1 ATOM 6475 C CB . LEU B 1 465 ? -36.304 -51.211 -13.368 1.00 88.67 ? 438 LEU A CB 1 ATOM 6476 C CG . LEU B 1 465 ? -35.913 -52.687 -13.205 1.00 96.55 ? 438 LEU A CG 1 ATOM 6477 C CD1 . LEU B 1 465 ? -37.059 -53.611 -13.626 1.00 94.30 ? 438 LEU A CD1 1 ATOM 6478 C CD2 . LEU B 1 465 ? -34.615 -53.004 -13.956 1.00 91.28 ? 438 LEU A CD2 1 ATOM 6479 N N . PRO B 1 466 ? -34.793 -48.177 -14.217 1.00 98.05 ? 439 PRO A N 1 ATOM 6480 C CA . PRO B 1 466 ? -35.028 -46.758 -14.472 1.00 107.20 ? 439 PRO A CA 1 ATOM 6481 C C . PRO B 1 466 ? -36.487 -46.473 -14.813 1.00 102.46 ? 439 PRO A C 1 ATOM 6482 O O . PRO B 1 466 ? -37.051 -47.154 -15.654 1.00 116.31 ? 439 PRO A O 1 ATOM 6483 C CB . PRO B 1 466 ? -34.097 -46.464 -15.650 1.00 111.37 ? 439 PRO A CB 1 ATOM 6484 C CG . PRO B 1 466 ? -32.981 -47.452 -15.483 1.00 107.77 ? 439 PRO A CG 1 ATOM 6485 C CD . PRO B 1 466 ? -33.667 -48.699 -15.019 1.00 101.64 ? 439 PRO A CD 1 ATOM 6486 N N . GLY B 1 467 ? -37.096 -45.505 -14.134 1.00 99.15 ? 440 GLY A N 1 ATOM 6487 C CA . GLY B 1 467 ? -38.528 -45.227 -14.286 1.00 100.06 ? 440 GLY A CA 1 ATOM 6488 C C . GLY B 1 467 ? -39.413 -45.857 -13.206 1.00 106.67 ? 440 GLY A C 1 ATOM 6489 O O . GLY B 1 467 ? -40.460 -45.300 -12.849 1.00 101.60 ? 440 GLY A O 1 ATOM 6490 N N . ARG B 1 468 ? -39.018 -47.020 -12.687 1.00 106.92 ? 441 ARG A N 1 ATOM 6491 C CA . ARG B 1 468 ? -39.760 -47.665 -11.593 1.00 108.62 ? 441 ARG A CA 1 ATOM 6492 C C . ARG B 1 468 ? -39.154 -47.381 -10.188 1.00 108.02 ? 441 ARG A C 1 ATOM 6493 O O . ARG B 1 468 ? -39.696 -47.831 -9.171 1.00 103.96 ? 441 ARG A O 1 ATOM 6494 C CB . ARG B 1 468 ? -39.858 -49.175 -11.860 1.00 101.56 ? 441 ARG A CB 1 ATOM 6495 N N . GLY B 1 469 ? -38.063 -46.610 -10.142 1.00 107.69 ? 442 GLY A N 1 ATOM 6496 C CA . GLY B 1 469 ? -37.324 -46.325 -8.903 1.00 105.08 ? 442 GLY A CA 1 ATOM 6497 C C . GLY B 1 469 ? -37.978 -45.354 -7.926 1.00 106.87 ? 442 GLY A C 1 ATOM 6498 O O . GLY B 1 469 ? -39.137 -44.963 -8.095 1.00 103.79 ? 442 GLY A O 1 ATOM 6499 N N . LEU B 1 470 ? -37.216 -44.958 -6.903 1.00 106.01 ? 443 LEU A N 1 ATOM 6500 C CA . LEU B 1 470 ? -37.749 -44.186 -5.765 1.00 94.73 ? 443 LEU A CA 1 ATOM 6501 C C . LEU B 1 470 ? -37.514 -42.682 -5.831 1.00 86.64 ? 443 LEU A C 1 ATOM 6502 O O . LEU B 1 470 ? -38.211 -41.916 -5.168 1.00 77.96 ? 443 LEU A O 1 ATOM 6503 C CB . LEU B 1 470 ? -37.155 -44.712 -4.464 1.00 89.53 ? 443 LEU A CB 1 ATOM 6504 C CG . LEU B 1 470 ? -37.724 -46.048 -4.000 1.00 89.59 ? 443 LEU A CG 1 ATOM 6505 C CD1 . LEU B 1 470 ? -36.889 -46.602 -2.859 1.00 95.17 ? 443 LEU A CD1 1 ATOM 6506 C CD2 . LEU B 1 470 ? -39.178 -45.907 -3.576 1.00 81.41 ? 443 LEU A CD2 1 ATOM 6507 N N . PHE B 1 471 ? -36.553 -42.264 -6.641 1.00 87.83 ? 444 PHE A N 1 ATOM 6508 C CA . PHE B 1 471 ? -36.107 -40.877 -6.654 1.00 92.82 ? 444 PHE A CA 1 ATOM 6509 C C . PHE B 1 471 ? -36.847 -39.981 -7.658 1.00 101.26 ? 444 PHE A C 1 ATOM 6510 O O . PHE B 1 471 ? -38.013 -40.241 -7.962 1.00 102.92 ? 444 PHE A O 1 ATOM 6511 C CB . PHE B 1 471 ? -34.595 -40.885 -6.816 1.00 88.42 ? 444 PHE A CB 1 ATOM 6512 C CG . PHE B 1 471 ? -33.921 -41.664 -5.734 1.00 91.43 ? 444 PHE A CG 1 ATOM 6513 C CD1 . PHE B 1 471 ? -33.802 -41.129 -4.459 1.00 91.83 ? 444 PHE A CD1 1 ATOM 6514 C CD2 . PHE B 1 471 ? -33.490 -42.953 -5.955 1.00 94.70 ? 444 PHE A CD2 1 ATOM 6515 C CE1 . PHE B 1 471 ? -33.214 -41.852 -3.445 1.00 91.89 ? 444 PHE A CE1 1 ATOM 6516 C CE2 . PHE B 1 471 ? -32.901 -43.686 -4.943 1.00 95.06 ? 444 PHE A CE2 1 ATOM 6517 C CZ . PHE B 1 471 ? -32.763 -43.135 -3.687 1.00 93.32 ? 444 PHE A CZ 1 ATOM 6518 N N . THR B 1 472 ? -36.195 -38.898 -8.097 1.00 114.31 ? 445 THR A N 1 ATOM 6519 C CA . THR B 1 472 ? -36.792 -37.875 -8.972 1.00 119.29 ? 445 THR A CA 1 ATOM 6520 C C . THR B 1 472 ? -37.177 -38.473 -10.318 1.00 126.77 ? 445 THR A C 1 ATOM 6521 O O . THR B 1 472 ? -36.358 -39.149 -10.948 1.00 125.51 ? 445 THR A O 1 ATOM 6522 C CB . THR B 1 472 ? -35.799 -36.703 -9.207 1.00 116.94 ? 445 THR A CB 1 ATOM 6523 O OG1 . THR B 1 472 ? -35.652 -35.946 -8.000 1.00 117.12 ? 445 THR A OG1 1 ATOM 6524 C CG2 . THR B 1 472 ? -36.263 -35.767 -10.323 1.00 114.28 ? 445 THR A CG2 1 ATOM 6525 N N . ASN B 1 473 ? -38.414 -38.219 -10.754 1.00 131.05 ? 446 ASN A N 1 ATOM 6526 C CA . ASN B 1 473 ? -38.934 -38.767 -12.015 1.00 131.48 ? 446 ASN A CA 1 ATOM 6527 C C . ASN B 1 473 ? -38.642 -40.267 -12.091 1.00 128.82 ? 446 ASN A C 1 ATOM 6528 O O . ASN B 1 473 ? -38.024 -40.754 -13.048 1.00 119.46 ? 446 ASN A O 1 ATOM 6529 C CB . ASN B 1 473 ? -38.325 -38.035 -13.223 1.00 124.37 ? 446 ASN A CB 1 ATOM 6530 C CG . ASN B 1 473 ? -38.624 -36.551 -13.218 1.00 114.49 ? 446 ASN A CG 1 ATOM 6531 O OD1 . ASN B 1 473 ? -39.785 -36.139 -13.142 1.00 106.57 ? 446 ASN A OD1 1 ATOM 6532 N ND2 . ASN B 1 473 ? -37.576 -35.737 -13.305 1.00 110.91 ? 446 ASN A ND2 1 ATOM 6533 N N . GLY B 1 474 ? -39.052 -40.974 -11.040 1.00 118.49 ? 447 GLY A N 1 ATOM 6534 C CA . GLY B 1 474 ? -38.775 -42.399 -10.875 1.00 109.52 ? 447 GLY A CA 1 ATOM 6535 C C . GLY B 1 474 ? -37.331 -42.847 -11.051 1.00 104.84 ? 447 GLY A C 1 ATOM 6536 O O . GLY B 1 474 ? -37.097 -44.045 -11.184 1.00 111.92 ? 447 GLY A O 1 ATOM 6537 N N . SER B 1 475 ? -36.358 -41.926 -11.039 1.00 93.24 ? 448 SER A N 1 ATOM 6538 C CA . SER B 1 475 ? -34.974 -42.283 -11.402 1.00 92.06 ? 448 SER A CA 1 ATOM 6539 C C . SER B 1 475 ? -34.358 -43.230 -10.385 1.00 86.92 ? 448 SER A C 1 ATOM 6540 O O . SER B 1 475 ? -35.003 -43.602 -9.395 1.00 81.67 ? 448 SER A O 1 ATOM 6541 C CB . SER B 1 475 ? -34.082 -41.042 -11.600 1.00 96.35 ? 448 SER A CB 1 ATOM 6542 O OG . SER B 1 475 ? -33.864 -40.334 -10.394 1.00 105.79 ? 448 SER A OG 1 ATOM 6543 N N . CYS B 1 476 ? -33.122 -43.641 -10.646 1.00 84.38 ? 449 CYS A N 1 ATOM 6544 C CA . CYS B 1 476 ? -32.432 -44.569 -9.771 1.00 89.11 ? 449 CYS A CA 1 ATOM 6545 C C . CYS B 1 476 ? -31.119 -43.949 -9.332 1.00 90.78 ? 449 CYS A C 1 ATOM 6546 O O . CYS B 1 476 ? -30.855 -42.788 -9.638 1.00 88.72 ? 449 CYS A O 1 ATOM 6547 C CB . CYS B 1 476 ? -32.211 -45.914 -10.480 1.00 92.20 ? 449 CYS A CB 1 ATOM 6548 S SG . CYS B 1 476 ? -33.746 -46.785 -10.880 1.00 106.66 ? 449 CYS A SG 1 ATOM 6549 N N . ALA B 1 477 ? -30.312 -44.723 -8.606 1.00 88.99 ? 450 ALA A N 1 ATOM 6550 C CA . ALA B 1 477 ? -29.069 -44.248 -8.042 1.00 89.48 ? 450 ALA A CA 1 ATOM 6551 C C . ALA B 1 477 ? -27.926 -45.150 -8.463 1.00 87.36 ? 450 ALA A C 1 ATOM 6552 O O . ALA B 1 477 ? -28.009 -46.366 -8.339 1.00 87.19 ? 450 ALA A O 1 ATOM 6553 C CB . ALA B 1 477 ? -29.184 -44.233 -6.524 1.00 97.59 ? 450 ALA A CB 1 ATOM 6554 N N . ASP B 1 478 ? -26.846 -44.553 -8.939 1.00 90.26 ? 451 ASP A N 1 ATOM 6555 C CA . ASP B 1 478 ? -25.662 -45.321 -9.281 1.00 98.00 ? 451 ASP A CA 1 ATOM 6556 C C . ASP B 1 478 ? -25.098 -45.968 -8.018 1.00 92.55 ? 451 ASP A C 1 ATOM 6557 O O . ASP B 1 478 ? -24.750 -45.274 -7.071 1.00 102.89 ? 451 ASP A O 1 ATOM 6558 C CB . ASP B 1 478 ? -24.607 -44.427 -9.965 1.00 106.57 ? 451 ASP A CB 1 ATOM 6559 C CG . ASP B 1 478 ? -23.180 -45.004 -9.877 1.00 109.38 ? 451 ASP A CG 1 ATOM 6560 O OD1 . ASP B 1 478 ? -22.981 -46.224 -10.107 1.00 92.71 ? 451 ASP A OD1 1 ATOM 6561 O OD2 . ASP B 1 478 ? -22.252 -44.226 -9.559 1.00 114.54 ? 451 ASP A OD2 1 ATOM 6562 N N . ILE B 1 479 ? -25.011 -47.296 -8.026 1.00 91.80 ? 452 ILE A N 1 ATOM 6563 C CA . ILE B 1 479 ? -24.426 -48.059 -6.921 1.00 91.38 ? 452 ILE A CA 1 ATOM 6564 C C . ILE B 1 479 ? -22.893 -47.991 -6.871 1.00 98.73 ? 452 ILE A C 1 ATOM 6565 O O . ILE B 1 479 ? -22.288 -48.216 -5.821 1.00 104.70 ? 452 ILE A O 1 ATOM 6566 C CB . ILE B 1 479 ? -24.876 -49.543 -6.939 1.00 93.28 ? 452 ILE A CB 1 ATOM 6567 C CG1 . ILE B 1 479 ? -24.465 -50.226 -5.635 1.00 98.63 ? 452 ILE A CG1 1 ATOM 6568 C CG2 . ILE B 1 479 ? -24.292 -50.297 -8.130 1.00 90.63 ? 452 ILE A CG2 1 ATOM 6569 C CD1 . ILE B 1 479 ? -25.029 -51.612 -5.450 1.00 102.77 ? 452 ILE A CD1 1 ATOM 6570 N N . LYS B 1 480 ? -22.245 -47.709 -7.992 1.00 107.23 ? 453 LYS A N 1 ATOM 6571 C CA . LYS B 1 480 ? -20.794 -47.542 -7.960 1.00 114.20 ? 453 LYS A CA 1 ATOM 6572 C C . LYS B 1 480 ? -20.421 -46.293 -7.145 1.00 115.91 ? 453 LYS A C 1 ATOM 6573 O O . LYS B 1 480 ? -19.387 -46.282 -6.486 1.00 113.19 ? 453 LYS A O 1 ATOM 6574 C CB . LYS B 1 480 ? -20.213 -47.475 -9.377 1.00 119.78 ? 453 LYS A CB 1 ATOM 6575 N N . LYS B 1 481 ? -21.284 -45.271 -7.172 1.00 119.46 ? 454 LYS A N 1 ATOM 6576 C CA . LYS B 1 481 ? -21.064 -43.994 -6.465 1.00 117.24 ? 454 LYS A CA 1 ATOM 6577 C C . LYS B 1 481 ? -22.290 -43.614 -5.587 1.00 106.31 ? 454 LYS A C 1 ATOM 6578 O O . LYS B 1 481 ? -22.871 -42.532 -5.740 1.00 99.13 ? 454 LYS A O 1 ATOM 6579 C CB . LYS B 1 481 ? -20.735 -42.873 -7.476 1.00 103.13 ? 454 LYS A CB 1 ATOM 6580 N N . VAL B 1 482 ? -22.661 -44.497 -4.658 1.00 92.92 ? 455 VAL A N 1 ATOM 6581 C CA . VAL B 1 482 ? -23.864 -44.284 -3.816 1.00 93.53 ? 455 VAL A CA 1 ATOM 6582 C C . VAL B 1 482 ? -23.594 -43.238 -2.749 1.00 91.05 ? 455 VAL A C 1 ATOM 6583 O O . VAL B 1 482 ? -22.452 -43.056 -2.310 1.00 91.29 ? 455 VAL A O 1 ATOM 6584 C CB . VAL B 1 482 ? -24.329 -45.527 -3.005 1.00 93.30 ? 455 VAL A CB 1 ATOM 6585 C CG1 . VAL B 1 482 ? -25.846 -45.623 -3.016 1.00 90.99 ? 455 VAL A CG1 1 ATOM 6586 C CG2 . VAL B 1 482 ? -23.731 -46.819 -3.512 1.00 97.02 ? 455 VAL A CG2 1 ATOM 6587 N N . GLU B 1 483 ? -24.651 -42.584 -2.292 1.00 84.95 ? 456 GLU A N 1 ATOM 6588 C CA . GLU B 1 483 ? -24.530 -41.655 -1.176 1.00 82.45 ? 456 GLU A CA 1 ATOM 6589 C C . GLU B 1 483 ? -25.473 -42.034 -0.042 1.00 76.11 ? 456 GLU A C 1 ATOM 6590 O O . GLU B 1 483 ? -26.647 -42.359 -0.262 1.00 78.08 ? 456 GLU A O 1 ATOM 6591 C CB . GLU B 1 483 ? -24.780 -40.235 -1.649 1.00 81.38 ? 456 GLU A CB 1 ATOM 6592 C CG . GLU B 1 483 ? -23.772 -39.800 -2.696 1.00 89.58 ? 456 GLU A CG 1 ATOM 6593 C CD . GLU B 1 483 ? -24.133 -38.484 -3.355 1.00 98.46 ? 456 GLU A CD 1 ATOM 6594 O OE1 . GLU B 1 483 ? -25.342 -38.214 -3.542 1.00 97.68 ? 456 GLU A OE1 1 ATOM 6595 O OE2 . GLU B 1 483 ? -23.199 -37.726 -3.698 1.00 103.48 ? 456 GLU A OE2 1 ATOM 6596 N N . ALA B 1 484 ? -24.941 -41.983 1.174 1.00 71.41 ? 457 ALA A N 1 ATOM 6597 C CA . ALA B 1 484 ? -25.671 -42.373 2.390 1.00 65.76 ? 457 ALA A CA 1 ATOM 6598 C C . ALA B 1 484 ? -27.157 -42.111 2.362 1.00 60.20 ? 457 ALA A C 1 ATOM 6599 O O . ALA B 1 484 ? -27.923 -43.001 2.674 1.00 65.61 ? 457 ALA A O 1 ATOM 6600 C CB . ALA B 1 484 ? -25.078 -41.688 3.586 1.00 65.61 ? 457 ALA A CB 1 ATOM 6601 N N . TRP B 1 485 ? -27.567 -40.908 1.983 1.00 59.86 ? 458 TRP A N 1 ATOM 6602 C CA . TRP B 1 485 ? -29.004 -40.555 1.976 1.00 61.76 ? 458 TRP A CA 1 ATOM 6603 C C . TRP B 1 485 ? -29.851 -41.358 1.007 1.00 61.48 ? 458 TRP A C 1 ATOM 6604 O O . TRP B 1 485 ? -31.085 -41.381 1.125 1.00 58.45 ? 458 TRP A O 1 ATOM 6605 C CB . TRP B 1 485 ? -29.214 -39.069 1.675 1.00 62.25 ? 458 TRP A CB 1 ATOM 6606 C CG . TRP B 1 485 ? -28.824 -38.656 0.291 1.00 66.07 ? 458 TRP A CG 1 ATOM 6607 C CD1 . TRP B 1 485 ? -27.572 -38.327 -0.148 1.00 64.26 ? 458 TRP A CD1 1 ATOM 6608 C CD2 . TRP B 1 485 ? -29.693 -38.520 -0.836 1.00 65.52 ? 458 TRP A CD2 1 ATOM 6609 N NE1 . TRP B 1 485 ? -27.613 -37.991 -1.474 1.00 66.83 ? 458 TRP A NE1 1 ATOM 6610 C CE2 . TRP B 1 485 ? -28.905 -38.100 -1.922 1.00 69.54 ? 458 TRP A CE2 1 ATOM 6611 C CE3 . TRP B 1 485 ? -31.055 -38.728 -1.036 1.00 66.88 ? 458 TRP A CE3 1 ATOM 6612 C CZ2 . TRP B 1 485 ? -29.439 -37.876 -3.192 1.00 67.79 ? 458 TRP A CZ2 1 ATOM 6613 C CZ3 . TRP B 1 485 ? -31.583 -38.503 -2.298 1.00 68.72 ? 458 TRP A CZ3 1 ATOM 6614 C CH2 . TRP B 1 485 ? -30.773 -38.085 -3.357 1.00 67.22 ? 458 TRP A CH2 1 ATOM 6615 N N . GLN B 1 486 ? -29.206 -41.962 0.013 1.00 66.24 ? 459 GLN A N 1 ATOM 6616 C CA . GLN B 1 486 ? -29.923 -42.851 -0.906 1.00 69.33 ? 459 GLN A CA 1 ATOM 6617 C C . GLN B 1 486 ? -30.247 -44.156 -0.210 1.00 63.27 ? 459 GLN A C 1 ATOM 6618 O O . GLN B 1 486 ? -31.373 -44.652 -0.266 1.00 61.83 ? 459 GLN A O 1 ATOM 6619 C CB . GLN B 1 486 ? -29.121 -43.079 -2.177 1.00 74.21 ? 459 GLN A CB 1 ATOM 6620 C CG . GLN B 1 486 ? -29.254 -41.907 -3.140 1.00 77.00 ? 459 GLN A CG 1 ATOM 6621 C CD . GLN B 1 486 ? -28.077 -41.742 -4.083 1.00 76.72 ? 459 GLN A CD 1 ATOM 6622 O OE1 . GLN B 1 486 ? -27.051 -42.443 -3.997 1.00 64.93 ? 459 GLN A OE1 1 ATOM 6623 N NE2 . GLN B 1 486 ? -28.218 -40.786 -4.990 1.00 81.97 ? 459 GLN A NE2 1 ATOM 6624 N N . VAL B 1 487 ? -29.276 -44.679 0.510 1.00 54.76 ? 460 VAL A N 1 ATOM 6625 C CA . VAL B 1 487 ? -29.565 -45.806 1.358 1.00 52.75 ? 460 VAL A CA 1 ATOM 6626 C C . VAL B 1 487 ? -30.669 -45.446 2.374 1.00 56.15 ? 460 VAL A C 1 ATOM 6627 O O . VAL B 1 487 ? -31.557 -46.238 2.642 1.00 52.22 ? 460 VAL A O 1 ATOM 6628 C CB . VAL B 1 487 ? -28.320 -46.269 2.093 1.00 52.54 ? 460 VAL A CB 1 ATOM 6629 C CG1 . VAL B 1 487 ? -28.576 -47.633 2.685 1.00 54.59 ? 460 VAL A CG1 1 ATOM 6630 C CG2 . VAL B 1 487 ? -27.124 -46.295 1.151 1.00 57.23 ? 460 VAL A CG2 1 ATOM 6631 N N . LEU B 1 488 ? -30.617 -44.248 2.953 1.00 65.64 ? 461 LEU A N 1 ATOM 6632 C CA . LEU B 1 488 ? -31.643 -43.857 3.923 1.00 61.57 ? 461 LEU A CA 1 ATOM 6633 C C . LEU B 1 488 ? -32.988 -44.014 3.243 1.00 56.14 ? 461 LEU A C 1 ATOM 6634 O O . LEU B 1 488 ? -33.865 -44.744 3.709 1.00 54.04 ? 461 LEU A O 1 ATOM 6635 C CB . LEU B 1 488 ? -31.462 -42.416 4.417 1.00 60.20 ? 461 LEU A CB 1 ATOM 6636 C CG . LEU B 1 488 ? -31.797 -42.097 5.890 1.00 56.74 ? 461 LEU A CG 1 ATOM 6637 C CD1 . LEU B 1 488 ? -32.311 -40.678 6.011 1.00 55.18 ? 461 LEU A CD1 1 ATOM 6638 C CD2 . LEU B 1 488 ? -32.805 -43.037 6.520 1.00 56.72 ? 461 LEU A CD2 1 ATOM 6639 N N . LYS B 1 489 ? -33.123 -43.367 2.102 1.00 56.15 ? 462 LYS A N 1 ATOM 6640 C CA . LYS B 1 489 ? -34.357 -43.467 1.325 1.00 63.21 ? 462 LYS A CA 1 ATOM 6641 C C . LYS B 1 489 ? -34.812 -44.916 1.118 1.00 64.43 ? 462 LYS A C 1 ATOM 6642 O O . LYS B 1 489 ? -35.966 -45.272 1.367 1.00 60.56 ? 462 LYS A O 1 ATOM 6643 C CB . LYS B 1 489 ? -34.174 -42.793 -0.020 1.00 61.10 ? 462 LYS A CB 1 ATOM 6644 C CG . LYS B 1 489 ? -35.387 -42.858 -0.905 1.00 64.53 ? 462 LYS A CG 1 ATOM 6645 C CD . LYS B 1 489 ? -36.571 -42.159 -0.292 1.00 66.68 ? 462 LYS A CD 1 ATOM 6646 C CE . LYS B 1 489 ? -37.743 -42.169 -1.248 1.00 68.66 ? 462 LYS A CE 1 ATOM 6647 N NZ . LYS B 1 489 ? -38.765 -41.147 -0.892 1.00 74.43 ? 462 LYS A NZ 1 ATOM 6648 N N . HIS B 1 490 ? -33.893 -45.756 0.677 1.00 62.27 ? 463 HIS A N 1 ATOM 6649 C CA . HIS B 1 490 ? -34.250 -47.131 0.434 1.00 63.26 ? 463 HIS A CA 1 ATOM 6650 C C . HIS B 1 490 ? -34.591 -47.856 1.717 1.00 61.31 ? 463 HIS A C 1 ATOM 6651 O O . HIS B 1 490 ? -35.519 -48.644 1.740 1.00 68.90 ? 463 HIS A O 1 ATOM 6652 C CB . HIS B 1 490 ? -33.162 -47.861 -0.367 1.00 69.14 ? 463 HIS A CB 1 ATOM 6653 C CG . HIS B 1 490 ? -33.376 -47.776 -1.847 1.00 73.85 ? 463 HIS A CG 1 ATOM 6654 N ND1 . HIS B 1 490 ? -34.166 -48.671 -2.534 1.00 75.17 ? 463 HIS A ND1 1 ATOM 6655 C CD2 . HIS B 1 490 ? -32.948 -46.870 -2.759 1.00 76.36 ? 463 HIS A CD2 1 ATOM 6656 C CE1 . HIS B 1 490 ? -34.202 -48.327 -3.809 1.00 81.97 ? 463 HIS A CE1 1 ATOM 6657 N NE2 . HIS B 1 490 ? -33.467 -47.241 -3.973 1.00 79.81 ? 463 HIS A NE2 1 ATOM 6658 N N . LEU B 1 491 ? -33.862 -47.584 2.786 1.00 59.37 ? 464 LEU A N 1 ATOM 6659 C CA . LEU B 1 491 ? -34.192 -48.175 4.060 1.00 59.19 ? 464 LEU A CA 1 ATOM 6660 C C . LEU B 1 491 ? -35.616 -47.797 4.531 1.00 61.25 ? 464 LEU A C 1 ATOM 6661 O O . LEU B 1 491 ? -36.337 -48.632 5.100 1.00 63.95 ? 464 LEU A O 1 ATOM 6662 C CB . LEU B 1 491 ? -33.158 -47.782 5.096 1.00 57.16 ? 464 LEU A CB 1 ATOM 6663 C CG . LEU B 1 491 ? -31.902 -48.619 5.020 1.00 57.93 ? 464 LEU A CG 1 ATOM 6664 C CD1 . LEU B 1 491 ? -30.817 -47.921 5.818 1.00 59.03 ? 464 LEU A CD1 1 ATOM 6665 C CD2 . LEU B 1 491 ? -32.137 -50.042 5.524 1.00 56.27 ? 464 LEU A CD2 1 ATOM 6666 N N . ARG B 1 492 ? -36.052 -46.574 4.268 1.00 57.27 ? 465 ARG A N 1 ATOM 6667 C CA . ARG B 1 492 ? -37.407 -46.188 4.689 1.00 60.79 ? 465 ARG A CA 1 ATOM 6668 C C . ARG B 1 492 ? -38.443 -47.044 4.022 1.00 61.71 ? 465 ARG A C 1 ATOM 6669 O O . ARG B 1 492 ? -39.487 -47.302 4.615 1.00 63.86 ? 465 ARG A O 1 ATOM 6670 C CB . ARG B 1 492 ? -37.732 -44.724 4.373 1.00 65.67 ? 465 ARG A CB 1 ATOM 6671 C CG . ARG B 1 492 ? -36.788 -43.738 5.025 1.00 66.64 ? 465 ARG A CG 1 ATOM 6672 C CD . ARG B 1 492 ? -37.381 -42.350 5.037 1.00 72.20 ? 465 ARG A CD 1 ATOM 6673 N NE . ARG B 1 492 ? -36.541 -41.475 5.849 1.00 72.37 ? 465 ARG A NE 1 ATOM 6674 C CZ . ARG B 1 492 ? -36.534 -40.150 5.775 1.00 68.52 ? 465 ARG A CZ 1 ATOM 6675 N NH1 . ARG B 1 492 ? -37.317 -39.506 4.914 1.00 75.59 ? 465 ARG A NH1 1 ATOM 6676 N NH2 . ARG B 1 492 ? -35.717 -39.465 6.557 1.00 68.99 ? 465 ARG A NH2 1 ATOM 6677 N N . HIS B 1 493 ? -38.180 -47.463 2.782 1.00 65.10 ? 466 HIS A N 1 ATOM 6678 C CA . HIS B 1 493 ? -39.178 -48.236 2.028 1.00 68.56 ? 466 HIS A CA 1 ATOM 6679 C C . HIS B 1 493 ? -38.851 -49.743 1.919 1.00 62.48 ? 466 HIS A C 1 ATOM 6680 O O . HIS B 1 493 ? -39.598 -50.510 1.344 1.00 65.62 ? 466 HIS A O 1 ATOM 6681 C CB . HIS B 1 493 ? -39.449 -47.557 0.677 1.00 68.60 ? 466 HIS A CB 1 ATOM 6682 C CG . HIS B 1 493 ? -39.789 -46.099 0.807 1.00 76.22 ? 466 HIS A CG 1 ATOM 6683 N ND1 . HIS B 1 493 ? -40.529 -45.597 1.864 1.00 81.74 ? 466 HIS A ND1 1 ATOM 6684 C CD2 . HIS B 1 493 ? -39.469 -45.033 0.034 1.00 75.54 ? 466 HIS A CD2 1 ATOM 6685 C CE1 . HIS B 1 493 ? -40.653 -44.287 1.734 1.00 76.88 ? 466 HIS A CE1 1 ATOM 6686 N NE2 . HIS B 1 493 ? -40.015 -43.919 0.633 1.00 80.60 ? 466 HIS A NE2 1 ATOM 6687 N N . LEU B 1 494 ? -37.773 -50.168 2.553 1.00 58.63 ? 467 LEU A N 1 ATOM 6688 C CA . LEU B 1 494 ? -37.363 -51.551 2.499 1.00 64.18 ? 467 LEU A CA 1 ATOM 6689 C C . LEU B 1 494 ? -38.452 -52.515 3.001 1.00 72.65 ? 467 LEU A C 1 ATOM 6690 O O . LEU B 1 494 ? -39.255 -52.194 3.902 1.00 72.54 ? 467 LEU A O 1 ATOM 6691 C CB . LEU B 1 494 ? -36.085 -51.724 3.320 1.00 66.60 ? 467 LEU A CB 1 ATOM 6692 C CG . LEU B 1 494 ? -35.424 -53.099 3.346 1.00 70.30 ? 467 LEU A CG 1 ATOM 6693 C CD1 . LEU B 1 494 ? -34.852 -53.387 1.979 1.00 72.68 ? 467 LEU A CD1 1 ATOM 6694 C CD2 . LEU B 1 494 ? -34.329 -53.196 4.413 1.00 70.09 ? 467 LEU A CD2 1 ATOM 6695 N N . ASN B 1 495 ? -38.441 -53.696 2.386 1.00 77.19 ? 468 ASN A N 1 ATOM 6696 C CA . ASN B 1 495 ? -39.348 -54.797 2.663 1.00 70.55 ? 468 ASN A CA 1 ATOM 6697 C C . ASN B 1 495 ? -38.668 -56.051 2.145 1.00 71.23 ? 468 ASN A C 1 ATOM 6698 O O . ASN B 1 495 ? -38.434 -56.179 0.948 1.00 79.81 ? 468 ASN A O 1 ATOM 6699 C CB . ASN B 1 495 ? -40.661 -54.595 1.924 1.00 71.58 ? 468 ASN A CB 1 ATOM 6700 C CG . ASN B 1 495 ? -41.747 -55.529 2.407 1.00 81.86 ? 468 ASN A CG 1 ATOM 6701 O OD1 . ASN B 1 495 ? -41.481 -56.468 3.154 1.00 86.38 ? 468 ASN A OD1 1 ATOM 6702 N ND2 . ASN B 1 495 ? -43.000 -55.264 1.980 1.00 96.34 ? 468 ASN A ND2 1 ATOM 6703 N N . PHE B 1 496 ? -38.299 -56.950 3.040 1.00 68.28 ? 469 PHE A N 1 ATOM 6704 C CA . PHE B 1 496 ? -37.638 -58.169 2.647 1.00 64.39 ? 469 PHE A CA 1 ATOM 6705 C C . PHE B 1 496 ? -37.931 -59.285 3.640 1.00 72.31 ? 469 PHE A C 1 ATOM 6706 O O . PHE B 1 496 ? -38.549 -59.063 4.699 1.00 63.96 ? 469 PHE A O 1 ATOM 6707 C CB . PHE B 1 496 ? -36.146 -57.940 2.548 1.00 66.54 ? 469 PHE A CB 1 ATOM 6708 C CG . PHE B 1 496 ? -35.449 -57.875 3.887 1.00 75.77 ? 469 PHE A CG 1 ATOM 6709 C CD1 . PHE B 1 496 ? -35.274 -56.662 4.543 1.00 69.54 ? 469 PHE A CD1 1 ATOM 6710 C CD2 . PHE B 1 496 ? -34.959 -59.033 4.489 1.00 78.87 ? 469 PHE A CD2 1 ATOM 6711 C CE1 . PHE B 1 496 ? -34.636 -56.607 5.765 1.00 67.14 ? 469 PHE A CE1 1 ATOM 6712 C CE2 . PHE B 1 496 ? -34.324 -58.979 5.710 1.00 72.91 ? 469 PHE A CE2 1 ATOM 6713 C CZ . PHE B 1 496 ? -34.159 -57.760 6.346 1.00 71.76 ? 469 PHE A CZ 1 ATOM 6714 N N . THR B 1 497 ? -37.470 -60.485 3.289 1.00 74.27 ? 470 THR A N 1 ATOM 6715 C CA . THR B 1 497 ? -37.793 -61.691 4.035 1.00 78.00 ? 470 THR A CA 1 ATOM 6716 C C . THR B 1 497 ? -36.563 -62.248 4.730 1.00 81.25 ? 470 THR A C 1 ATOM 6717 O O . THR B 1 497 ? -35.603 -62.654 4.077 1.00 86.79 ? 470 THR A O 1 ATOM 6718 C CB . THR B 1 497 ? -38.351 -62.779 3.101 1.00 77.48 ? 470 THR A CB 1 ATOM 6719 O OG1 . THR B 1 497 ? -39.372 -62.218 2.274 1.00 74.34 ? 470 THR A OG1 1 ATOM 6720 C CG2 . THR B 1 497 ? -38.930 -63.941 3.912 1.00 84.71 ? 470 THR A CG2 1 ATOM 6721 N N . ASN B 1 498 ? -36.587 -62.296 6.054 1.00 80.38 ? 471 ASN A N 1 ATOM 6722 C CA . ASN B 1 498 ? -35.454 -62.863 6.769 1.00 80.57 ? 471 ASN A CA 1 ATOM 6723 C C . ASN B 1 498 ? -35.385 -64.390 6.688 1.00 81.45 ? 471 ASN A C 1 ATOM 6724 O O . ASN B 1 498 ? -36.295 -65.060 6.182 1.00 78.63 ? 471 ASN A O 1 ATOM 6725 C CB . ASN B 1 498 ? -35.391 -62.359 8.232 1.00 85.47 ? 471 ASN A CB 1 ATOM 6726 C CG . ASN B 1 498 ? -36.598 -62.769 9.086 1.00 83.67 ? 471 ASN A CG 1 ATOM 6727 O OD1 . ASN B 1 498 ? -37.269 -63.760 8.821 1.00 79.97 ? 471 ASN A OD1 1 ATOM 6728 N ND2 . ASN B 1 498 ? -36.844 -62.011 10.148 1.00 81.34 ? 471 ASN A ND2 1 ATOM 6729 N N . ASN B 1 499 ? -34.268 -64.913 7.175 1.00 88.34 ? 472 ASN A N 1 ATOM 6730 C CA . ASN B 1 499 ? -34.027 -66.354 7.285 1.00 89.19 ? 472 ASN A CA 1 ATOM 6731 C C . ASN B 1 499 ? -35.037 -67.126 8.144 1.00 90.23 ? 472 ASN A C 1 ATOM 6732 O O . ASN B 1 499 ? -35.112 -68.347 8.046 1.00 99.02 ? 472 ASN A O 1 ATOM 6733 C CB . ASN B 1 499 ? -32.607 -66.615 7.809 1.00 85.23 ? 472 ASN A CB 1 ATOM 6734 C CG . ASN B 1 499 ? -32.436 -66.216 9.264 1.00 89.85 ? 472 ASN A CG 1 ATOM 6735 O OD1 . ASN B 1 499 ? -32.092 -67.040 10.117 1.00 83.46 ? 472 ASN A OD1 1 ATOM 6736 N ND2 . ASN B 1 499 ? -32.699 -64.947 9.560 1.00 92.80 ? 472 ASN A ND2 1 ATOM 6737 N N . MET B 1 500 ? -35.794 -66.430 8.988 1.00 85.99 ? 473 MET A N 1 ATOM 6738 C CA . MET B 1 500 ? -36.870 -67.066 9.756 1.00 87.36 ? 473 MET A CA 1 ATOM 6739 C C . MET B 1 500 ? -38.199 -67.096 8.979 1.00 89.41 ? 473 MET A C 1 ATOM 6740 O O . MET B 1 500 ? -39.213 -67.539 9.513 1.00 83.57 ? 473 MET A O 1 ATOM 6741 C CB . MET B 1 500 ? -37.092 -66.333 11.088 1.00 85.78 ? 473 MET A CB 1 ATOM 6742 C CG . MET B 1 500 ? -35.865 -66.208 11.973 1.00 86.35 ? 473 MET A CG 1 ATOM 6743 S SD . MET B 1 500 ? -35.366 -67.721 12.795 1.00 102.40 ? 473 MET A SD 1 ATOM 6744 C CE . MET B 1 500 ? -36.894 -68.125 13.664 1.00 95.02 ? 473 MET A CE 1 ATOM 6745 N N . GLY B 1 501 ? -38.202 -66.607 7.739 1.00 97.20 ? 474 GLY A N 1 ATOM 6746 C CA . GLY B 1 501 ? -39.439 -66.478 6.949 1.00 102.77 ? 474 GLY A CA 1 ATOM 6747 C C . GLY B 1 501 ? -40.399 -65.354 7.356 1.00 100.59 ? 474 GLY A C 1 ATOM 6748 O O . GLY B 1 501 ? -41.618 -65.532 7.307 1.00 90.09 ? 474 GLY A O 1 ATOM 6749 N N . GLU B 1 502 ? -39.855 -64.192 7.728 1.00 99.89 ? 475 GLU A N 1 ATOM 6750 C CA . GLU B 1 502 ? -40.660 -63.036 8.160 1.00 93.01 ? 475 GLU A CA 1 ATOM 6751 C C . GLU B 1 502 ? -40.452 -61.793 7.270 1.00 81.99 ? 475 GLU A C 1 ATOM 6752 O O . GLU B 1 502 ? -39.406 -61.634 6.624 1.00 67.99 ? 475 GLU A O 1 ATOM 6753 C CB . GLU B 1 502 ? -40.342 -62.692 9.618 1.00 98.04 ? 475 GLU A CB 1 ATOM 6754 C CG . GLU B 1 502 ? -40.702 -63.781 10.623 1.00 101.10 ? 475 GLU A CG 1 ATOM 6755 C CD . GLU B 1 502 ? -42.086 -63.586 11.212 1.00 105.09 ? 475 GLU A CD 1 ATOM 6756 O OE1 . GLU B 1 502 ? -42.208 -62.834 12.206 1.00 97.78 ? 475 GLU A OE1 1 ATOM 6757 O OE2 . GLU B 1 502 ? -43.050 -64.184 10.683 1.00 106.48 ? 475 GLU A OE2 1 ATOM 6758 N N . GLN B 1 503 ? -41.469 -60.932 7.233 1.00 75.70 ? 476 GLN A N 1 ATOM 6759 C CA . GLN B 1 503 ? -41.388 -59.671 6.511 1.00 80.81 ? 476 GLN A CA 1 ATOM 6760 C C . GLN B 1 503 ? -40.826 -58.617 7.417 1.00 74.72 ? 476 GLN A C 1 ATOM 6761 O O . GLN B 1 503 ? -41.418 -58.328 8.439 1.00 76.69 ? 476 GLN A O 1 ATOM 6762 C CB . GLN B 1 503 ? -42.755 -59.212 5.992 1.00 85.40 ? 476 GLN A CB 1 ATOM 6763 C CG . GLN B 1 503 ? -43.304 -60.083 4.874 1.00 89.43 ? 476 GLN A CG 1 ATOM 6764 C CD . GLN B 1 503 ? -42.240 -60.412 3.848 1.00 96.76 ? 476 GLN A CD 1 ATOM 6765 O OE1 . GLN B 1 503 ? -41.612 -59.506 3.294 1.00 112.01 ? 476 GLN A OE1 1 ATOM 6766 N NE2 . GLN B 1 503 ? -42.004 -61.705 3.611 1.00 91.41 ? 476 GLN A NE2 1 ATOM 6767 N N . VAL B 1 504 ? -39.683 -58.053 7.025 1.00 74.38 ? 477 VAL A N 1 ATOM 6768 C CA . VAL B 1 504 ? -39.023 -56.995 7.776 1.00 70.82 ? 477 VAL A CA 1 ATOM 6769 C C . VAL B 1 504 ? -39.223 -55.676 7.047 1.00 66.30 ? 477 VAL A C 1 ATOM 6770 O O . VAL B 1 504 ? -38.651 -55.458 5.992 1.00 79.23 ? 477 VAL A O 1 ATOM 6771 C CB . VAL B 1 504 ? -37.517 -57.299 7.961 1.00 74.55 ? 477 VAL A CB 1 ATOM 6772 C CG1 . VAL B 1 504 ? -36.818 -56.189 8.720 1.00 70.16 ? 477 VAL A CG1 1 ATOM 6773 C CG2 . VAL B 1 504 ? -37.330 -58.609 8.719 1.00 76.08 ? 477 VAL A CG2 1 ATOM 6774 N N . THR B 1 505 ? -40.091 -54.834 7.594 1.00 64.22 ? 478 THR A N 1 ATOM 6775 C CA . THR B 1 505 ? -40.240 -53.450 7.169 1.00 69.64 ? 478 THR A CA 1 ATOM 6776 C C . THR B 1 505 ? -40.280 -52.539 8.391 1.00 63.81 ? 478 THR A C 1 ATOM 6777 O O . THR B 1 505 ? -40.607 -52.982 9.483 1.00 59.51 ? 478 THR A O 1 ATOM 6778 C CB . THR B 1 505 ? -41.565 -53.193 6.438 1.00 73.47 ? 478 THR A CB 1 ATOM 6779 O OG1 . THR B 1 505 ? -42.654 -53.522 7.310 1.00 67.78 ? 478 THR A OG1 1 ATOM 6780 C CG2 . THR B 1 505 ? -41.656 -53.996 5.180 1.00 79.47 ? 478 THR A CG2 1 ATOM 6781 N N . PHE B 1 506 ? -39.977 -51.265 8.166 1.00 59.26 ? 479 PHE A N 1 ATOM 6782 C CA . PHE B 1 506 ? -39.975 -50.253 9.204 1.00 61.20 ? 479 PHE A CA 1 ATOM 6783 C C . PHE B 1 506 ? -41.153 -49.302 8.925 1.00 63.60 ? 479 PHE A C 1 ATOM 6784 O O . PHE B 1 506 ? -41.458 -49.022 7.763 1.00 64.60 ? 479 PHE A O 1 ATOM 6785 C CB . PHE B 1 506 ? -38.642 -49.468 9.229 1.00 58.32 ? 479 PHE A CB 1 ATOM 6786 C CG . PHE B 1 506 ? -37.408 -50.329 9.271 1.00 60.62 ? 479 PHE A CG 1 ATOM 6787 C CD1 . PHE B 1 506 ? -36.916 -50.823 10.486 1.00 65.51 ? 479 PHE A CD1 1 ATOM 6788 C CD2 . PHE B 1 506 ? -36.710 -50.635 8.106 1.00 64.16 ? 479 PHE A CD2 1 ATOM 6789 C CE1 . PHE B 1 506 ? -35.767 -51.630 10.531 1.00 63.00 ? 479 PHE A CE1 1 ATOM 6790 C CE2 . PHE B 1 506 ? -35.562 -51.427 8.148 1.00 64.78 ? 479 PHE A CE2 1 ATOM 6791 C CZ . PHE B 1 506 ? -35.089 -51.927 9.360 1.00 59.87 ? 479 PHE A CZ 1 ATOM 6792 N N . ASP B 1 507 ? -41.820 -48.822 9.976 1.00 61.20 ? 480 ASP A N 1 ATOM 6793 C CA . ASP B 1 507 ? -42.997 -47.965 9.799 1.00 61.41 ? 480 ASP A CA 1 ATOM 6794 C C . ASP B 1 507 ? -42.566 -46.532 9.490 1.00 60.20 ? 480 ASP A C 1 ATOM 6795 O O . ASP B 1 507 ? -41.380 -46.270 9.279 1.00 58.25 ? 480 ASP A O 1 ATOM 6796 C CB . ASP B 1 507 ? -43.949 -48.040 11.018 1.00 65.63 ? 480 ASP A CB 1 ATOM 6797 C CG . ASP B 1 507 ? -43.328 -47.504 12.310 1.00 72.23 ? 480 ASP A CG 1 ATOM 6798 O OD1 . ASP B 1 507 ? -42.330 -46.753 12.255 1.00 81.82 ? 480 ASP A OD1 1 ATOM 6799 O OD2 . ASP B 1 507 ? -43.842 -47.835 13.398 1.00 73.54 ? 480 ASP A OD2 1 ATOM 6800 N N . GLU B 1 508 ? -43.538 -45.623 9.449 1.00 60.83 ? 481 GLU A N 1 ATOM 6801 C CA . GLU B 1 508 ? -43.301 -44.196 9.208 1.00 62.74 ? 481 GLU A CA 1 ATOM 6802 C C . GLU B 1 508 ? -42.264 -43.564 10.200 1.00 66.01 ? 481 GLU A C 1 ATOM 6803 O O . GLU B 1 508 ? -41.598 -42.566 9.858 1.00 63.61 ? 481 GLU A O 1 ATOM 6804 C CB . GLU B 1 508 ? -44.657 -43.440 9.228 1.00 59.40 ? 481 GLU A CB 1 HETATM 6805 N N . CSO B 1 509 ? -42.121 -44.163 11.393 1.00 60.92 ? 482 CSO A N 1 HETATM 6806 C CA . CSO B 1 509 ? -41.167 -43.720 12.414 1.00 58.77 ? 482 CSO A CA 1 HETATM 6807 C CB . CSO B 1 509 ? -41.859 -43.762 13.776 1.00 65.91 ? 482 CSO A CB 1 HETATM 6808 S SG . CSO B 1 509 ? -43.248 -42.677 13.783 1.00 67.80 ? 482 CSO A SG 1 HETATM 6809 C C . CSO B 1 509 ? -39.901 -44.538 12.487 1.00 58.36 ? 482 CSO A C 1 HETATM 6810 O O . CSO B 1 509 ? -39.039 -44.294 13.337 1.00 63.60 ? 482 CSO A O 1 HETATM 6811 O OD . CSO B 1 509 ? -44.570 -43.812 13.881 1.00 82.69 ? 482 CSO A OD 1 ATOM 6812 N N . GLY B 1 510 ? -39.752 -45.518 11.602 1.00 57.93 ? 483 GLY A N 1 ATOM 6813 C CA . GLY B 1 510 ? -38.506 -46.275 11.502 1.00 51.59 ? 483 GLY A CA 1 ATOM 6814 C C . GLY B 1 510 ? -38.428 -47.318 12.582 1.00 50.24 ? 483 GLY A C 1 ATOM 6815 O O . GLY B 1 510 ? -37.349 -47.729 12.968 1.00 54.66 ? 483 GLY A O 1 ATOM 6816 N N . ASP B 1 511 ? -39.586 -47.744 13.059 1.00 51.98 ? 484 ASP A N 1 ATOM 6817 C CA . ASP B 1 511 ? -39.692 -48.729 14.107 1.00 60.84 ? 484 ASP A CA 1 ATOM 6818 C C . ASP B 1 511 ? -40.144 -50.080 13.519 1.00 65.00 ? 484 ASP A C 1 ATOM 6819 O O . ASP B 1 511 ? -40.632 -50.175 12.401 1.00 70.49 ? 484 ASP A O 1 ATOM 6820 C CB . ASP B 1 511 ? -40.728 -48.276 15.167 1.00 68.04 ? 484 ASP A CB 1 ATOM 6821 C CG . ASP B 1 511 ? -40.305 -47.005 15.980 1.00 72.32 ? 484 ASP A CG 1 ATOM 6822 O OD1 . ASP B 1 511 ? -39.102 -46.797 16.331 1.00 73.34 ? 484 ASP A OD1 1 ATOM 6823 O OD2 . ASP B 1 511 ? -41.231 -46.225 16.305 1.00 66.57 ? 484 ASP A OD2 1 ATOM 6824 N N . LEU B 1 512 ? -40.045 -51.114 14.329 1.00 70.10 ? 485 LEU A N 1 ATOM 6825 C CA . LEU B 1 512 ? -40.390 -52.445 13.931 1.00 65.66 ? 485 LEU A CA 1 ATOM 6826 C C . LEU B 1 512 ? -41.144 -53.058 15.117 1.00 69.97 ? 485 LEU A C 1 ATOM 6827 O O . LEU B 1 512 ? -40.635 -53.086 16.244 1.00 74.12 ? 485 LEU A O 1 ATOM 6828 C CB . LEU B 1 512 ? -39.091 -53.183 13.632 1.00 64.87 ? 485 LEU A CB 1 ATOM 6829 C CG . LEU B 1 512 ? -39.127 -54.655 13.310 1.00 74.59 ? 485 LEU A CG 1 ATOM 6830 C CD1 . LEU B 1 512 ? -40.012 -54.857 12.081 1.00 86.52 ? 485 LEU A CD1 1 ATOM 6831 C CD2 . LEU B 1 512 ? -37.712 -55.174 13.066 1.00 76.27 ? 485 LEU A CD2 1 ATOM 6832 N N . VAL B 1 513 ? -42.368 -53.519 14.872 1.00 71.98 ? 486 VAL A N 1 ATOM 6833 C CA . VAL B 1 513 ? -43.161 -54.238 15.891 1.00 66.79 ? 486 VAL A CA 1 ATOM 6834 C C . VAL B 1 513 ? -42.648 -55.635 16.224 1.00 62.51 ? 486 VAL A C 1 ATOM 6835 O O . VAL B 1 513 ? -41.996 -56.303 15.418 1.00 60.58 ? 486 VAL A O 1 ATOM 6836 C CB . VAL B 1 513 ? -44.636 -54.378 15.492 1.00 76.04 ? 486 VAL A CB 1 ATOM 6837 C CG1 . VAL B 1 513 ? -45.322 -53.015 15.458 1.00 75.61 ? 486 VAL A CG1 1 ATOM 6838 C CG2 . VAL B 1 513 ? -44.760 -55.070 14.142 1.00 88.73 ? 486 VAL A CG2 1 ATOM 6839 N N . GLY B 1 514 ? -42.954 -56.061 17.443 1.00 61.51 ? 487 GLY A N 1 ATOM 6840 C CA . GLY B 1 514 ? -42.505 -57.338 17.964 1.00 56.56 ? 487 GLY A CA 1 ATOM 6841 C C . GLY B 1 514 ? -43.318 -57.740 19.168 1.00 54.95 ? 487 GLY A C 1 ATOM 6842 O O . GLY B 1 514 ? -43.689 -56.899 19.974 1.00 58.42 ? 487 GLY A O 1 ATOM 6843 N N . ASN B 1 515 ? -43.621 -59.024 19.297 1.00 58.91 ? 488 ASN A N 1 ATOM 6844 C CA . ASN B 1 515 ? -44.230 -59.500 20.538 1.00 61.33 ? 488 ASN A CA 1 ATOM 6845 C C . ASN B 1 515 ? -43.163 -59.630 21.614 1.00 62.53 ? 488 ASN A C 1 ATOM 6846 O O . ASN B 1 515 ? -42.005 -59.284 21.400 1.00 61.68 ? 488 ASN A O 1 ATOM 6847 C CB . ASN B 1 515 ? -44.910 -60.838 20.356 1.00 61.30 ? 488 ASN A CB 1 ATOM 6848 C CG . ASN B 1 515 ? -46.094 -60.781 19.404 1.00 70.80 ? 488 ASN A CG 1 ATOM 6849 O OD1 . ASN B 1 515 ? -46.774 -59.753 19.259 1.00 59.55 ? 488 ASN A OD1 1 ATOM 6850 N ND2 . ASN B 1 515 ? -46.350 -61.933 18.744 1.00 82.51 ? 488 ASN A ND2 1 ATOM 6851 N N . TYR B 1 516 ? -43.568 -60.105 22.785 1.00 63.36 ? 489 TYR A N 1 ATOM 6852 C CA . TYR B 1 516 ? -42.655 -60.329 23.884 1.00 59.43 ? 489 TYR A CA 1 ATOM 6853 C C . TYR B 1 516 ? -43.002 -61.676 24.557 1.00 58.80 ? 489 TYR A C 1 ATOM 6854 O O . TYR B 1 516 ? -44.169 -62.067 24.653 1.00 58.87 ? 489 TYR A O 1 ATOM 6855 C CB . TYR B 1 516 ? -42.783 -59.207 24.903 1.00 59.83 ? 489 TYR A CB 1 ATOM 6856 C CG . TYR B 1 516 ? -42.412 -57.799 24.456 1.00 65.86 ? 489 TYR A CG 1 ATOM 6857 C CD1 . TYR B 1 516 ? -41.096 -57.343 24.510 1.00 62.02 ? 489 TYR A CD1 1 ATOM 6858 C CD2 . TYR B 1 516 ? -43.392 -56.896 24.064 1.00 70.19 ? 489 TYR A CD2 1 ATOM 6859 C CE1 . TYR B 1 516 ? -40.769 -56.050 24.151 1.00 63.67 ? 489 TYR A CE1 1 ATOM 6860 C CE2 . TYR B 1 516 ? -43.073 -55.595 23.698 1.00 74.30 ? 489 TYR A CE2 1 ATOM 6861 C CZ . TYR B 1 516 ? -41.761 -55.170 23.745 1.00 73.81 ? 489 TYR A CZ 1 ATOM 6862 O OH . TYR B 1 516 ? -41.465 -53.859 23.387 1.00 82.53 ? 489 TYR A OH 1 ATOM 6863 N N . SER B 1 517 ? -41.983 -62.391 24.989 1.00 55.13 ? 490 SER A N 1 ATOM 6864 C CA . SER B 1 517 ? -42.161 -63.437 25.970 1.00 59.83 ? 490 SER A CA 1 ATOM 6865 C C . SER B 1 517 ? -42.207 -62.795 27.338 1.00 55.51 ? 490 SER A C 1 ATOM 6866 O O . SER B 1 517 ? -41.620 -61.720 27.554 1.00 54.02 ? 490 SER A O 1 ATOM 6867 C CB . SER B 1 517 ? -40.984 -64.416 25.957 1.00 63.67 ? 490 SER A CB 1 ATOM 6868 O OG . SER B 1 517 ? -41.375 -65.632 25.362 1.00 78.67 ? 490 SER A OG 1 ATOM 6869 N N . ILE B 1 518 ? -42.832 -63.490 28.278 1.00 46.45 ? 491 ILE A N 1 ATOM 6870 C CA . ILE B 1 518 ? -42.780 -63.078 29.652 1.00 47.10 ? 491 ILE A CA 1 ATOM 6871 C C . ILE B 1 518 ? -42.132 -64.195 30.392 1.00 50.82 ? 491 ILE A C 1 ATOM 6872 O O . ILE B 1 518 ? -42.571 -65.318 30.246 1.00 55.04 ? 491 ILE A O 1 ATOM 6873 C CB . ILE B 1 518 ? -44.167 -62.792 30.224 1.00 49.73 ? 491 ILE A CB 1 ATOM 6874 C CG1 . ILE B 1 518 ? -44.836 -61.683 29.426 1.00 50.82 ? 491 ILE A CG1 1 ATOM 6875 C CG2 . ILE B 1 518 ? -44.076 -62.372 31.683 1.00 49.25 ? 491 ILE A CG2 1 ATOM 6876 C CD1 . ILE B 1 518 ? -46.305 -61.598 29.683 1.00 56.51 ? 491 ILE A CD1 1 ATOM 6877 N N . ILE B 1 519 ? -41.111 -63.863 31.197 1.00 56.22 ? 492 ILE A N 1 ATOM 6878 C CA . ILE B 1 519 ? -40.226 -64.823 31.853 1.00 54.05 ? 492 ILE A CA 1 ATOM 6879 C C . ILE B 1 519 ? -40.100 -64.563 33.324 1.00 56.60 ? 492 ILE A C 1 ATOM 6880 O O . ILE B 1 519 ? -40.289 -63.437 33.786 1.00 62.00 ? 492 ILE A O 1 ATOM 6881 C CB . ILE B 1 519 ? -38.784 -64.761 31.316 1.00 57.33 ? 492 ILE A CB 1 ATOM 6882 C CG1 . ILE B 1 519 ? -38.179 -63.374 31.577 1.00 59.40 ? 492 ILE A CG1 1 ATOM 6883 C CG2 . ILE B 1 519 ? -38.771 -65.165 29.840 1.00 57.01 ? 492 ILE A CG2 1 ATOM 6884 C CD1 . ILE B 1 519 ? -36.665 -63.298 31.475 1.00 63.71 ? 492 ILE A CD1 1 ATOM 6885 N N . ASN B 1 520 ? -39.725 -65.615 34.049 1.00 55.48 ? 493 ASN A N 1 ATOM 6886 C CA . ASN B 1 520 ? -39.751 -65.604 35.498 1.00 54.23 ? 493 ASN A CA 1 ATOM 6887 C C . ASN B 1 520 ? -38.471 -66.246 35.949 1.00 53.63 ? 493 ASN A C 1 ATOM 6888 O O . ASN B 1 520 ? -38.009 -67.200 35.336 1.00 62.06 ? 493 ASN A O 1 ATOM 6889 C CB . ASN B 1 520 ? -40.995 -66.365 35.995 1.00 56.44 ? 493 ASN A CB 1 ATOM 6890 C CG . ASN B 1 520 ? -41.258 -66.219 37.500 1.00 56.35 ? 493 ASN A CG 1 ATOM 6891 O OD1 . ASN B 1 520 ? -40.825 -65.274 38.179 1.00 57.20 ? 493 ASN A OD1 1 ATOM 6892 N ND2 . ASN B 1 520 ? -42.002 -67.164 38.019 1.00 54.95 ? 493 ASN A ND2 1 ATOM 6893 N N . TRP B 1 521 ? -37.881 -65.688 36.993 1.00 54.79 ? 494 TRP A N 1 ATOM 6894 C CA . TRP B 1 521 ? -36.545 -66.072 37.427 1.00 60.45 ? 494 TRP A CA 1 ATOM 6895 C C . TRP B 1 521 ? -36.612 -67.256 38.417 1.00 67.04 ? 494 TRP A C 1 ATOM 6896 O O . TRP B 1 521 ? -36.883 -67.064 39.622 1.00 60.76 ? 494 TRP A O 1 ATOM 6897 C CB . TRP B 1 521 ? -35.832 -64.861 38.056 1.00 53.51 ? 494 TRP A CB 1 ATOM 6898 C CG . TRP B 1 521 ? -35.364 -63.808 37.055 1.00 54.43 ? 494 TRP A CG 1 ATOM 6899 C CD1 . TRP B 1 521 ? -35.840 -63.590 35.782 1.00 57.66 ? 494 TRP A CD1 1 ATOM 6900 C CD2 . TRP B 1 521 ? -34.350 -62.823 37.268 1.00 46.02 ? 494 TRP A CD2 1 ATOM 6901 N NE1 . TRP B 1 521 ? -35.162 -62.545 35.196 1.00 56.60 ? 494 TRP A NE1 1 ATOM 6902 C CE2 . TRP B 1 521 ? -34.235 -62.074 36.087 1.00 48.83 ? 494 TRP A CE2 1 ATOM 6903 C CE3 . TRP B 1 521 ? -33.512 -62.530 38.337 1.00 49.70 ? 494 TRP A CE3 1 ATOM 6904 C CZ2 . TRP B 1 521 ? -33.325 -61.052 35.950 1.00 53.11 ? 494 TRP A CZ2 1 ATOM 6905 C CZ3 . TRP B 1 521 ? -32.615 -61.507 38.219 1.00 55.31 ? 494 TRP A CZ3 1 ATOM 6906 C CH2 . TRP B 1 521 ? -32.524 -60.769 37.031 1.00 58.36 ? 494 TRP A CH2 1 ATOM 6907 N N . HIS B 1 522 ? -36.370 -68.469 37.903 1.00 69.82 ? 495 HIS A N 1 ATOM 6908 C CA . HIS B 1 522 ? -36.204 -69.673 38.748 1.00 71.13 ? 495 HIS A CA 1 ATOM 6909 C C . HIS B 1 522 ? -34.733 -69.959 39.080 1.00 68.09 ? 495 HIS A C 1 ATOM 6910 O O . HIS B 1 522 ? -33.844 -69.427 38.444 1.00 65.28 ? 495 HIS A O 1 ATOM 6911 C CB . HIS B 1 522 ? -36.821 -70.902 38.077 1.00 70.14 ? 495 HIS A CB 1 ATOM 6912 C CG . HIS B 1 522 ? -38.269 -70.744 37.716 1.00 74.15 ? 495 HIS A CG 1 ATOM 6913 N ND1 . HIS B 1 522 ? -39.097 -69.815 38.312 1.00 84.10 ? 495 HIS A ND1 1 ATOM 6914 C CD2 . HIS B 1 522 ? -39.041 -71.421 36.837 1.00 76.25 ? 495 HIS A CD2 1 ATOM 6915 C CE1 . HIS B 1 522 ? -40.310 -69.913 37.799 1.00 80.57 ? 495 HIS A CE1 1 ATOM 6916 N NE2 . HIS B 1 522 ? -40.301 -70.875 36.896 1.00 86.87 ? 495 HIS A NE2 1 ATOM 6917 N N . LEU B 1 523 ? -34.494 -70.767 40.112 1.00 76.17 ? 496 LEU A N 1 ATOM 6918 C CA . LEU B 1 523 ? -33.169 -71.378 40.339 1.00 77.65 ? 496 LEU A CA 1 ATOM 6919 C C . LEU B 1 523 ? -33.122 -72.732 39.660 1.00 79.55 ? 496 LEU A C 1 ATOM 6920 O O . LEU B 1 523 ? -34.131 -73.437 39.612 1.00 76.95 ? 496 LEU A O 1 ATOM 6921 C CB . LEU B 1 523 ? -32.856 -71.564 41.828 1.00 74.00 ? 496 LEU A CB 1 ATOM 6922 C CG . LEU B 1 523 ? -31.798 -70.631 42.396 1.00 76.18 ? 496 LEU A CG 1 ATOM 6923 C CD1 . LEU B 1 523 ? -31.622 -70.870 43.884 1.00 75.97 ? 496 LEU A CD1 1 ATOM 6924 C CD2 . LEU B 1 523 ? -30.473 -70.835 41.681 1.00 83.41 ? 496 LEU A CD2 1 ATOM 6925 N N . SER B 1 524 ? -31.954 -73.086 39.132 1.00 87.53 ? 497 SER A N 1 ATOM 6926 C CA . SER B 1 524 ? -31.733 -74.429 38.603 1.00 96.68 ? 497 SER A CA 1 ATOM 6927 C C . SER B 1 524 ? -31.484 -75.403 39.758 1.00 94.72 ? 497 SER A C 1 ATOM 6928 O O . SER B 1 524 ? -30.622 -75.157 40.615 1.00 84.70 ? 497 SER A O 1 ATOM 6929 C CB . SER B 1 524 ? -30.531 -74.458 37.664 1.00 106.26 ? 497 SER A CB 1 ATOM 6930 O OG . SER B 1 524 ? -30.432 -75.712 37.011 1.00 106.90 ? 497 SER A OG 1 ATOM 6931 N N . PRO B 1 525 ? -32.234 -76.513 39.784 1.00 97.88 ? 498 PRO A N 1 ATOM 6932 C CA . PRO B 1 525 ? -32.053 -77.523 40.829 1.00 102.77 ? 498 PRO A CA 1 ATOM 6933 C C . PRO B 1 525 ? -30.735 -78.317 40.680 1.00 111.73 ? 498 PRO A C 1 ATOM 6934 O O . PRO B 1 525 ? -30.070 -78.591 41.682 1.00 116.32 ? 498 PRO A O 1 ATOM 6935 C CB . PRO B 1 525 ? -33.262 -78.431 40.635 1.00 103.80 ? 498 PRO A CB 1 ATOM 6936 C CG . PRO B 1 525 ? -33.581 -78.331 39.175 1.00 99.06 ? 498 PRO A CG 1 ATOM 6937 C CD . PRO B 1 525 ? -33.208 -76.938 38.759 1.00 97.54 ? 498 PRO A CD 1 ATOM 6938 N N . GLU B 1 526 ? -30.369 -78.674 39.447 1.00 108.56 ? 499 GLU A N 1 ATOM 6939 C CA . GLU B 1 526 ? -29.048 -79.228 39.143 1.00 113.36 ? 499 GLU A CA 1 ATOM 6940 C C . GLU B 1 526 ? -27.940 -78.192 39.382 1.00 110.27 ? 499 GLU A C 1 ATOM 6941 O O . GLU B 1 526 ? -27.059 -78.351 40.232 1.00 105.49 ? 499 GLU A O 1 ATOM 6942 C CB . GLU B 1 526 ? -29.003 -79.658 37.669 1.00 112.69 ? 499 GLU A CB 1 ATOM 6943 N N . ASP B 1 527 ? -28.043 -77.100 38.641 1.00 111.89 ? 500 ASP A N 1 ATOM 6944 C CA . ASP B 1 527 ? -26.952 -76.145 38.443 1.00 103.88 ? 500 ASP A CA 1 ATOM 6945 C C . ASP B 1 527 ? -26.715 -75.091 39.552 1.00 95.57 ? 500 ASP A C 1 ATOM 6946 O O . ASP B 1 527 ? -25.612 -74.558 39.665 1.00 80.10 ? 500 ASP A O 1 ATOM 6947 C CB . ASP B 1 527 ? -27.217 -75.422 37.114 1.00 98.61 ? 500 ASP A CB 1 ATOM 6948 C CG . ASP B 1 527 ? -25.966 -74.973 36.446 1.00 99.98 ? 500 ASP A CG 1 ATOM 6949 O OD1 . ASP B 1 527 ? -24.965 -74.762 37.162 1.00 102.81 ? 500 ASP A OD1 1 ATOM 6950 O OD2 . ASP B 1 527 ? -25.986 -74.832 35.201 1.00 106.56 ? 500 ASP A OD2 1 ATOM 6951 N N . GLY B 1 528 ? -27.749 -74.755 40.324 1.00 92.51 ? 501 GLY A N 1 ATOM 6952 C CA . GLY B 1 528 ? -27.683 -73.625 41.254 1.00 90.70 ? 501 GLY A CA 1 ATOM 6953 C C . GLY B 1 528 ? -27.662 -72.262 40.552 1.00 93.59 ? 501 GLY A C 1 ATOM 6954 O O . GLY B 1 528 ? -27.558 -71.209 41.218 1.00 87.79 ? 501 GLY A O 1 ATOM 6955 N N . SER B 1 529 ? -27.758 -72.275 39.216 1.00 77.93 ? 502 SER A N 1 ATOM 6956 C CA . SER B 1 529 ? -27.720 -71.059 38.426 1.00 75.50 ? 502 SER A CA 1 ATOM 6957 C C . SER B 1 529 ? -29.147 -70.635 38.197 1.00 84.94 ? 502 SER A C 1 ATOM 6958 O O . SER B 1 529 ? -30.079 -71.423 38.415 1.00 87.96 ? 502 SER A O 1 ATOM 6959 C CB . SER B 1 529 ? -27.005 -71.268 37.079 1.00 73.48 ? 502 SER A CB 1 ATOM 6960 O OG . SER B 1 529 ? -27.878 -71.688 36.036 1.00 63.78 ? 502 SER A OG 1 ATOM 6961 N N . ILE B 1 530 ? -29.304 -69.394 37.738 1.00 81.19 ? 503 ILE A N 1 ATOM 6962 C CA . ILE B 1 530 ? -30.606 -68.792 37.527 1.00 75.16 ? 503 ILE A CA 1 ATOM 6963 C C . ILE B 1 530 ? -31.082 -69.068 36.113 1.00 74.02 ? 503 ILE A C 1 ATOM 6964 O O . ILE B 1 530 ? -30.298 -69.061 35.172 1.00 80.19 ? 503 ILE A O 1 ATOM 6965 C CB . ILE B 1 530 ? -30.564 -67.281 37.835 1.00 79.91 ? 503 ILE A CB 1 ATOM 6966 C CG1 . ILE B 1 530 ? -30.494 -67.093 39.358 1.00 83.43 ? 503 ILE A CG1 1 ATOM 6967 C CG2 . ILE B 1 530 ? -31.784 -66.561 37.274 1.00 80.10 ? 503 ILE A CG2 1 ATOM 6968 C CD1 . ILE B 1 530 ? -30.098 -65.709 39.819 1.00 82.69 ? 503 ILE A CD1 1 ATOM 6969 N N . VAL B 1 531 ? -32.385 -69.288 35.993 1.00 73.25 ? 504 VAL A N 1 ATOM 6970 C CA . VAL B 1 531 ? -33.006 -69.810 34.798 1.00 76.82 ? 504 VAL A CA 1 ATOM 6971 C C . VAL B 1 531 ? -34.196 -68.931 34.419 1.00 78.16 ? 504 VAL A C 1 ATOM 6972 O O . VAL B 1 531 ? -35.032 -68.572 35.270 1.00 69.68 ? 504 VAL A O 1 ATOM 6973 C CB . VAL B 1 531 ? -33.517 -71.250 35.048 1.00 80.71 ? 504 VAL A CB 1 ATOM 6974 C CG1 . VAL B 1 531 ? -34.001 -71.898 33.754 1.00 84.35 ? 504 VAL A CG1 1 ATOM 6975 C CG2 . VAL B 1 531 ? -32.423 -72.088 35.688 1.00 84.59 ? 504 VAL A CG2 1 ATOM 6976 N N . PHE B 1 532 ? -34.291 -68.605 33.137 1.00 70.16 ? 505 PHE A N 1 ATOM 6977 C CA . PHE B 1 532 ? -35.371 -67.759 32.683 1.00 70.25 ? 505 PHE A CA 1 ATOM 6978 C C . PHE B 1 532 ? -36.475 -68.641 32.103 1.00 68.64 ? 505 PHE A C 1 ATOM 6979 O O . PHE B 1 532 ? -36.436 -69.033 30.947 1.00 63.55 ? 505 PHE A O 1 ATOM 6980 C CB . PHE B 1 532 ? -34.842 -66.682 31.710 1.00 65.79 ? 505 PHE A CB 1 ATOM 6981 C CG . PHE B 1 532 ? -33.694 -65.885 32.274 1.00 60.90 ? 505 PHE A CG 1 ATOM 6982 C CD1 . PHE B 1 532 ? -33.818 -65.225 33.490 1.00 63.52 ? 505 PHE A CD1 1 ATOM 6983 C CD2 . PHE B 1 532 ? -32.487 -65.831 31.623 1.00 62.55 ? 505 PHE A CD2 1 ATOM 6984 C CE1 . PHE B 1 532 ? -32.760 -64.508 34.032 1.00 62.88 ? 505 PHE A CE1 1 ATOM 6985 C CE2 . PHE B 1 532 ? -31.429 -65.123 32.156 1.00 62.85 ? 505 PHE A CE2 1 ATOM 6986 C CZ . PHE B 1 532 ? -31.562 -64.456 33.355 1.00 62.76 ? 505 PHE A CZ 1 ATOM 6987 N N . LYS B 1 533 ? -37.457 -68.950 32.939 1.00 71.55 ? 506 LYS A N 1 ATOM 6988 C CA . LYS B 1 533 ? -38.586 -69.797 32.550 1.00 80.66 ? 506 LYS A CA 1 ATOM 6989 C C . LYS B 1 533 ? -39.652 -68.927 31.907 1.00 73.44 ? 506 LYS A C 1 ATOM 6990 O O . LYS B 1 533 ? -40.094 -67.969 32.531 1.00 75.71 ? 506 LYS A O 1 ATOM 6991 C CB . LYS B 1 533 ? -39.177 -70.482 33.807 1.00 88.43 ? 506 LYS A CB 1 ATOM 6992 C CG . LYS B 1 533 ? -39.869 -71.833 33.605 1.00 90.01 ? 506 LYS A CG 1 ATOM 6993 C CD . LYS B 1 533 ? -40.795 -71.872 32.390 1.00 96.50 ? 506 LYS A CD 1 ATOM 6994 C CE . LYS B 1 533 ? -41.858 -72.971 32.472 1.00 98.46 ? 506 LYS A CE 1 ATOM 6995 N NZ . LYS B 1 533 ? -41.336 -74.347 32.717 1.00 99.91 ? 506 LYS A NZ 1 ATOM 6996 N N . GLU B 1 534 ? -40.084 -69.255 30.687 1.00 73.45 ? 507 GLU A N 1 ATOM 6997 C CA . GLU B 1 534 ? -41.219 -68.530 30.070 1.00 71.00 ? 507 GLU A CA 1 ATOM 6998 C C . GLU B 1 534 ? -42.542 -68.854 30.749 1.00 72.62 ? 507 GLU A C 1 ATOM 6999 O O . GLU B 1 534 ? -42.914 -70.021 30.881 1.00 83.95 ? 507 GLU A O 1 ATOM 7000 C CB . GLU B 1 534 ? -41.402 -68.845 28.588 1.00 69.36 ? 507 GLU A CB 1 ATOM 7001 C CG . GLU B 1 534 ? -42.587 -68.077 28.012 1.00 73.89 ? 507 GLU A CG 1 ATOM 7002 C CD . GLU B 1 534 ? -43.026 -68.499 26.620 1.00 77.53 ? 507 GLU A CD 1 ATOM 7003 O OE1 . GLU B 1 534 ? -42.193 -68.506 25.674 1.00 71.68 ? 507 GLU A OE1 1 ATOM 7004 O OE2 . GLU B 1 534 ? -44.244 -68.775 26.480 1.00 85.76 ? 507 GLU A OE2 1 ATOM 7005 N N . VAL B 1 535 ? -43.287 -67.823 31.127 1.00 66.22 ? 508 VAL A N 1 ATOM 7006 C CA . VAL B 1 535 ? -44.562 -68.029 31.778 1.00 57.31 ? 508 VAL A CA 1 ATOM 7007 C C . VAL B 1 535 ? -45.710 -67.248 31.161 1.00 60.10 ? 508 VAL A C 1 ATOM 7008 O O . VAL B 1 535 ? -46.828 -67.251 31.686 1.00 61.84 ? 508 VAL A O 1 ATOM 7009 C CB . VAL B 1 535 ? -44.442 -67.695 33.250 1.00 56.75 ? 508 VAL A CB 1 ATOM 7010 C CG1 . VAL B 1 535 ? -43.187 -68.358 33.802 1.00 55.71 ? 508 VAL A CG1 1 ATOM 7011 C CG2 . VAL B 1 535 ? -44.398 -66.184 33.444 1.00 63.52 ? 508 VAL A CG2 1 ATOM 7012 N N . GLY B 1 536 ? -45.476 -66.596 30.033 1.00 58.51 ? 509 GLY A N 1 ATOM 7013 C CA . GLY B 1 536 ? -46.574 -65.895 29.388 1.00 59.59 ? 509 GLY A CA 1 ATOM 7014 C C . GLY B 1 536 ? -46.056 -65.252 28.134 1.00 61.70 ? 509 GLY A C 1 ATOM 7015 O O . GLY B 1 536 ? -44.882 -65.426 27.802 1.00 60.36 ? 509 GLY A O 1 ATOM 7016 N N . TYR B 1 537 ? -46.940 -64.552 27.429 1.00 62.75 ? 510 TYR A N 1 ATOM 7017 C CA . TYR B 1 537 ? -46.573 -63.796 26.245 1.00 70.05 ? 510 TYR A CA 1 ATOM 7018 C C . TYR B 1 537 ? -47.406 -62.508 26.206 1.00 70.01 ? 510 TYR A C 1 ATOM 7019 O O . TYR B 1 537 ? -48.421 -62.389 26.929 1.00 66.37 ? 510 TYR A O 1 ATOM 7020 C CB . TYR B 1 537 ? -46.715 -64.633 24.942 1.00 74.66 ? 510 TYR A CB 1 ATOM 7021 C CG . TYR B 1 537 ? -48.096 -65.220 24.636 1.00 91.21 ? 510 TYR A CG 1 ATOM 7022 C CD1 . TYR B 1 537 ? -48.437 -66.529 25.040 1.00 99.96 ? 510 TYR A CD1 1 ATOM 7023 C CD2 . TYR B 1 537 ? -49.056 -64.490 23.912 1.00 98.83 ? 510 TYR A CD2 1 ATOM 7024 C CE1 . TYR B 1 537 ? -49.688 -67.072 24.751 1.00 96.43 ? 510 TYR A CE1 1 ATOM 7025 C CE2 . TYR B 1 537 ? -50.311 -65.029 23.621 1.00 94.31 ? 510 TYR A CE2 1 ATOM 7026 C CZ . TYR B 1 537 ? -50.621 -66.312 24.042 1.00 96.28 ? 510 TYR A CZ 1 ATOM 7027 O OH . TYR B 1 537 ? -51.861 -66.838 23.757 1.00 99.37 ? 510 TYR A OH 1 ATOM 7028 N N . TYR B 1 538 ? -46.940 -61.538 25.410 1.00 59.20 ? 511 TYR A N 1 ATOM 7029 C CA . TYR B 1 538 ? -47.704 -60.321 25.146 1.00 62.03 ? 511 TYR A CA 1 ATOM 7030 C C . TYR B 1 538 ? -47.828 -60.181 23.646 1.00 60.65 ? 511 TYR A C 1 ATOM 7031 O O . TYR B 1 538 ? -46.836 -60.076 22.958 1.00 61.38 ? 511 TYR A O 1 ATOM 7032 C CB . TYR B 1 538 ? -47.032 -59.082 25.767 1.00 60.21 ? 511 TYR A CB 1 ATOM 7033 C CG . TYR B 1 538 ? -47.917 -57.857 25.849 1.00 53.02 ? 511 TYR A CG 1 ATOM 7034 C CD1 . TYR B 1 538 ? -48.948 -57.786 26.790 1.00 57.72 ? 511 TYR A CD1 1 ATOM 7035 C CD2 . TYR B 1 538 ? -47.721 -56.766 25.007 1.00 51.76 ? 511 TYR A CD2 1 ATOM 7036 C CE1 . TYR B 1 538 ? -49.779 -56.673 26.873 1.00 59.50 ? 511 TYR A CE1 1 ATOM 7037 C CE2 . TYR B 1 538 ? -48.532 -55.640 25.098 1.00 55.82 ? 511 TYR A CE2 1 ATOM 7038 C CZ . TYR B 1 538 ? -49.568 -55.610 26.034 1.00 57.85 ? 511 TYR A CZ 1 ATOM 7039 O OH . TYR B 1 538 ? -50.382 -54.525 26.161 1.00 63.85 ? 511 TYR A OH 1 ATOM 7040 N N . ASN B 1 539 ? -49.043 -60.241 23.132 1.00 65.37 ? 512 ASN A N 1 ATOM 7041 C CA . ASN B 1 539 ? -49.226 -60.211 21.705 1.00 66.02 ? 512 ASN A CA 1 ATOM 7042 C C . ASN B 1 539 ? -49.684 -58.832 21.376 1.00 63.35 ? 512 ASN A C 1 ATOM 7043 O O . ASN B 1 539 ? -50.787 -58.443 21.735 1.00 60.99 ? 512 ASN A O 1 ATOM 7044 C CB . ASN B 1 539 ? -50.238 -61.265 21.248 1.00 70.83 ? 512 ASN A CB 1 ATOM 7045 C CG . ASN B 1 539 ? -50.698 -61.068 19.799 1.00 70.55 ? 512 ASN A CG 1 ATOM 7046 O OD1 . ASN B 1 539 ? -49.968 -60.572 18.942 1.00 74.21 ? 512 ASN A OD1 1 ATOM 7047 N ND2 . ASN B 1 539 ? -51.920 -61.465 19.529 1.00 67.91 ? 512 ASN A ND2 1 ATOM 7048 N N . VAL B 1 540 ? -48.818 -58.119 20.668 1.00 66.54 ? 513 VAL A N 1 ATOM 7049 C CA . VAL B 1 540 ? -48.986 -56.712 20.326 1.00 67.31 ? 513 VAL A CA 1 ATOM 7050 C C . VAL B 1 540 ? -50.087 -56.482 19.274 1.00 72.42 ? 513 VAL A C 1 ATOM 7051 O O . VAL B 1 540 ? -50.643 -55.380 19.183 1.00 70.48 ? 513 VAL A O 1 ATOM 7052 C CB . VAL B 1 540 ? -47.619 -56.166 19.849 1.00 70.42 ? 513 VAL A CB 1 ATOM 7053 C CG1 . VAL B 1 540 ? -47.748 -54.855 19.099 1.00 78.83 ? 513 VAL A CG1 1 ATOM 7054 C CG2 . VAL B 1 540 ? -46.699 -56.014 21.039 1.00 69.99 ? 513 VAL A CG2 1 ATOM 7055 N N . TYR B 1 541 ? -50.430 -57.523 18.510 1.00 77.83 ? 514 TYR A N 1 ATOM 7056 C CA . TYR B 1 541 ? -51.448 -57.418 17.435 1.00 81.64 ? 514 TYR A CA 1 ATOM 7057 C C . TYR B 1 541 ? -52.886 -57.568 17.915 1.00 77.61 ? 514 TYR A C 1 ATOM 7058 O O . TYR B 1 541 ? -53.799 -57.013 17.315 1.00 90.54 ? 514 TYR A O 1 ATOM 7059 C CB . TYR B 1 541 ? -51.164 -58.424 16.319 1.00 84.03 ? 514 TYR A CB 1 ATOM 7060 C CG . TYR B 1 541 ? -49.785 -58.237 15.733 1.00 88.14 ? 514 TYR A CG 1 ATOM 7061 C CD1 . TYR B 1 541 ? -49.572 -57.381 14.650 1.00 83.96 ? 514 TYR A CD1 1 ATOM 7062 C CD2 . TYR B 1 541 ? -48.681 -58.883 16.301 1.00 89.44 ? 514 TYR A CD2 1 ATOM 7063 C CE1 . TYR B 1 541 ? -48.301 -57.204 14.132 1.00 88.35 ? 514 TYR A CE1 1 ATOM 7064 C CE2 . TYR B 1 541 ? -47.412 -58.710 15.800 1.00 88.37 ? 514 TYR A CE2 1 ATOM 7065 C CZ . TYR B 1 541 ? -47.225 -57.879 14.718 1.00 91.13 ? 514 TYR A CZ 1 ATOM 7066 O OH . TYR B 1 541 ? -45.947 -57.739 14.256 1.00 88.78 ? 514 TYR A OH 1 ATOM 7067 N N . ALA B 1 542 ? -53.082 -58.299 19.005 1.00 77.92 ? 515 ALA A N 1 ATOM 7068 C CA . ALA B 1 542 ? -54.396 -58.425 19.650 1.00 70.82 ? 515 ALA A CA 1 ATOM 7069 C C . ALA B 1 542 ? -54.953 -57.084 20.133 1.00 69.83 ? 515 ALA A C 1 ATOM 7070 O O . ALA B 1 542 ? -54.201 -56.166 20.410 1.00 73.79 ? 515 ALA A O 1 ATOM 7071 C CB . ALA B 1 542 ? -54.300 -59.387 20.816 1.00 70.83 ? 515 ALA A CB 1 ATOM 7072 N N . LYS B 1 543 ? -56.275 -56.987 20.241 1.00 73.93 ? 516 LYS A N 1 ATOM 7073 C CA . LYS B 1 543 ? -56.935 -55.739 20.656 1.00 79.15 ? 516 LYS A CA 1 ATOM 7074 C C . LYS B 1 543 ? -56.649 -55.411 22.139 1.00 78.48 ? 516 LYS A C 1 ATOM 7075 O O . LYS B 1 543 ? -56.312 -56.309 22.920 1.00 75.38 ? 516 LYS A O 1 ATOM 7076 C CB . LYS B 1 543 ? -58.456 -55.808 20.380 1.00 72.43 ? 516 LYS A CB 1 ATOM 7077 N N . LYS B 1 544 ? -56.784 -54.126 22.503 1.00 77.47 ? 517 LYS A N 1 ATOM 7078 C CA . LYS B 1 544 ? -56.578 -53.636 23.882 1.00 72.73 ? 517 LYS A CA 1 ATOM 7079 C C . LYS B 1 544 ? -57.364 -54.507 24.869 1.00 76.67 ? 517 LYS A C 1 ATOM 7080 O O . LYS B 1 544 ? -58.516 -54.812 24.615 1.00 77.30 ? 517 LYS A O 1 ATOM 7081 C CB . LYS B 1 544 ? -57.005 -52.162 24.008 1.00 62.47 ? 517 LYS A CB 1 ATOM 7082 N N . GLY B 1 545 ? -56.731 -54.928 25.966 1.00 78.04 ? 518 GLY A N 1 ATOM 7083 C CA . GLY B 1 545 ? -57.378 -55.777 26.974 1.00 75.74 ? 518 GLY A CA 1 ATOM 7084 C C . GLY B 1 545 ? -57.243 -57.279 26.725 1.00 77.38 ? 518 GLY A C 1 ATOM 7085 O O . GLY B 1 545 ? -57.540 -58.072 27.609 1.00 72.54 ? 518 GLY A O 1 ATOM 7086 N N . GLU B 1 546 ? -56.788 -57.669 25.531 1.00 82.14 ? 519 GLU A N 1 ATOM 7087 C CA . GLU B 1 546 ? -56.680 -59.087 25.127 1.00 80.20 ? 519 GLU A CA 1 ATOM 7088 C C . GLU B 1 546 ? -55.273 -59.419 24.593 1.00 76.89 ? 519 GLU A C 1 ATOM 7089 O O . GLU B 1 546 ? -55.109 -60.274 23.718 1.00 72.32 ? 519 GLU A O 1 ATOM 7090 C CB . GLU B 1 546 ? -57.732 -59.391 24.045 1.00 77.80 ? 519 GLU A CB 1 ATOM 7091 N N . ARG B 1 547 ? -54.263 -58.731 25.120 1.00 74.40 ? 520 ARG A N 1 ATOM 7092 C CA . ARG B 1 547 ? -52.891 -58.860 24.628 1.00 68.34 ? 520 ARG A CA 1 ATOM 7093 C C . ARG B 1 547 ? -52.032 -59.681 25.556 1.00 63.66 ? 520 ARG A C 1 ATOM 7094 O O . ARG B 1 547 ? -51.117 -60.358 25.109 1.00 59.90 ? 520 ARG A O 1 ATOM 7095 C CB . ARG B 1 547 ? -52.249 -57.489 24.499 1.00 70.72 ? 520 ARG A CB 1 ATOM 7096 C CG . ARG B 1 547 ? -53.019 -56.551 23.601 1.00 65.19 ? 520 ARG A CG 1 ATOM 7097 C CD . ARG B 1 547 ? -52.073 -55.728 22.787 1.00 61.97 ? 520 ARG A CD 1 ATOM 7098 N NE . ARG B 1 547 ? -52.825 -54.753 22.035 1.00 69.40 ? 520 ARG A NE 1 ATOM 7099 C CZ . ARG B 1 547 ? -52.907 -53.456 22.314 1.00 70.31 ? 520 ARG A CZ 1 ATOM 7100 N NH1 . ARG B 1 547 ? -52.257 -52.910 23.350 1.00 78.26 ? 520 ARG A NH1 1 ATOM 7101 N NH2 . ARG B 1 547 ? -53.638 -52.697 21.524 1.00 60.80 ? 520 ARG A NH2 1 ATOM 7102 N N . LEU B 1 548 ? -52.310 -59.591 26.850 1.00 62.66 ? 521 LEU A N 1 ATOM 7103 C CA . LEU B 1 548 ? -51.573 -60.352 27.855 1.00 59.83 ? 521 LEU A CA 1 ATOM 7104 C C . LEU B 1 548 ? -52.098 -61.779 27.978 1.00 62.97 ? 521 LEU A C 1 ATOM 7105 O O . LEU B 1 548 ? -53.292 -62.017 27.896 1.00 66.97 ? 521 LEU A O 1 ATOM 7106 C CB . LEU B 1 548 ? -51.705 -59.676 29.216 1.00 53.71 ? 521 LEU A CB 1 ATOM 7107 C CG . LEU B 1 548 ? -51.040 -60.379 30.403 1.00 54.05 ? 521 LEU A CG 1 ATOM 7108 C CD1 . LEU B 1 548 ? -49.547 -60.616 30.224 1.00 48.96 ? 521 LEU A CD1 1 ATOM 7109 C CD2 . LEU B 1 548 ? -51.309 -59.579 31.666 1.00 57.34 ? 521 LEU A CD2 1 ATOM 7110 N N . PHE B 1 549 ? -51.184 -62.718 28.175 1.00 63.86 ? 522 PHE A N 1 ATOM 7111 C CA . PHE B 1 549 ? -51.529 -64.046 28.584 1.00 62.45 ? 522 PHE A CA 1 ATOM 7112 C C . PHE B 1 549 ? -50.528 -64.484 29.628 1.00 60.47 ? 522 PHE A C 1 ATOM 7113 O O . PHE B 1 549 ? -49.341 -64.318 29.418 1.00 69.68 ? 522 PHE A O 1 ATOM 7114 C CB . PHE B 1 549 ? -51.473 -64.984 27.382 1.00 67.58 ? 522 PHE A CB 1 ATOM 7115 C CG . PHE B 1 549 ? -51.601 -66.438 27.749 1.00 78.41 ? 522 PHE A CG 1 ATOM 7116 C CD1 . PHE B 1 549 ? -52.858 -67.006 27.948 1.00 75.41 ? 522 PHE A CD1 1 ATOM 7117 C CD2 . PHE B 1 549 ? -50.463 -67.234 27.930 1.00 81.33 ? 522 PHE A CD2 1 ATOM 7118 C CE1 . PHE B 1 549 ? -52.981 -68.335 28.294 1.00 75.71 ? 522 PHE A CE1 1 ATOM 7119 C CE2 . PHE B 1 549 ? -50.587 -68.563 28.283 1.00 81.39 ? 522 PHE A CE2 1 ATOM 7120 C CZ . PHE B 1 549 ? -51.852 -69.111 28.455 1.00 82.63 ? 522 PHE A CZ 1 ATOM 7121 N N . ILE B 1 550 ? -51.002 -65.072 30.724 1.00 63.95 ? 523 ILE A N 1 ATOM 7122 C CA . ILE B 1 550 ? -50.135 -65.606 31.781 1.00 69.53 ? 523 ILE A CA 1 ATOM 7123 C C . ILE B 1 550 ? -50.605 -66.975 32.285 1.00 73.44 ? 523 ILE A C 1 ATOM 7124 O O . ILE B 1 550 ? -51.795 -67.163 32.510 1.00 81.45 ? 523 ILE A O 1 ATOM 7125 C CB . ILE B 1 550 ? -50.102 -64.653 32.983 1.00 76.42 ? 523 ILE A CB 1 ATOM 7126 C CG1 . ILE B 1 550 ? -49.577 -63.289 32.547 1.00 85.33 ? 523 ILE A CG1 1 ATOM 7127 C CG2 . ILE B 1 550 ? -49.247 -65.230 34.109 1.00 80.54 ? 523 ILE A CG2 1 ATOM 7128 C CD1 . ILE B 1 550 ? -49.116 -62.405 33.690 1.00 90.58 ? 523 ILE A CD1 1 ATOM 7129 N N . ASN B 1 551 ? -49.668 -67.912 32.467 1.00 77.30 ? 524 ASN A N 1 ATOM 7130 C CA . ASN B 1 551 ? -49.936 -69.176 33.153 1.00 83.30 ? 524 ASN A CA 1 ATOM 7131 C C . ASN B 1 551 ? -49.548 -69.072 34.597 1.00 74.66 ? 524 ASN A C 1 ATOM 7132 O O . ASN B 1 551 ? -48.399 -69.342 34.932 1.00 75.99 ? 524 ASN A O 1 ATOM 7133 C CB . ASN B 1 551 ? -49.160 -70.351 32.542 1.00 94.60 ? 524 ASN A CB 1 ATOM 7134 C CG . ASN B 1 551 ? -49.701 -70.768 31.195 1.00 115.57 ? 524 ASN A CG 1 ATOM 7135 O OD1 . ASN B 1 551 ? -50.821 -70.417 30.835 1.00 138.41 ? 524 ASN A OD1 1 ATOM 7136 N ND2 . ASN B 1 551 ? -48.907 -71.519 30.439 1.00 126.27 ? 524 ASN A ND2 1 ATOM 7137 N N . GLU B 1 552 ? -50.505 -68.714 35.455 1.00 75.17 ? 525 GLU A N 1 ATOM 7138 C CA . GLU B 1 552 ? -50.270 -68.655 36.915 1.00 71.87 ? 525 GLU A CA 1 ATOM 7139 C C . GLU B 1 552 ? -49.537 -69.887 37.444 1.00 70.42 ? 525 GLU A C 1 ATOM 7140 O O . GLU B 1 552 ? -48.584 -69.747 38.208 1.00 70.40 ? 525 GLU A O 1 ATOM 7141 C CB . GLU B 1 552 ? -51.576 -68.513 37.699 1.00 74.17 ? 525 GLU A CB 1 ATOM 7142 C CG . GLU B 1 552 ? -52.146 -67.108 37.848 1.00 80.01 ? 525 GLU A CG 1 ATOM 7143 C CD . GLU B 1 552 ? -53.367 -66.868 36.978 1.00 86.14 ? 525 GLU A CD 1 ATOM 7144 O OE1 . GLU B 1 552 ? -53.305 -67.205 35.761 1.00 93.03 ? 525 GLU A OE1 1 ATOM 7145 O OE2 . GLU B 1 552 ? -54.375 -66.337 37.519 1.00 80.70 ? 525 GLU A OE2 1 ATOM 7146 N N . GLU B 1 553 ? -49.969 -71.083 37.026 1.00 70.89 ? 526 GLU A N 1 ATOM 7147 C CA . GLU B 1 553 ? -49.370 -72.345 37.503 1.00 73.80 ? 526 GLU A CA 1 ATOM 7148 C C . GLU B 1 553 ? -47.833 -72.409 37.282 1.00 77.86 ? 526 GLU A C 1 ATOM 7149 O O . GLU B 1 553 ? -47.103 -73.011 38.092 1.00 74.57 ? 526 GLU A O 1 ATOM 7150 C CB . GLU B 1 553 ? -50.067 -73.553 36.852 1.00 74.54 ? 526 GLU A CB 1 ATOM 7151 N N . LYS B 1 554 ? -47.351 -71.761 36.213 1.00 74.80 ? 527 LYS A N 1 ATOM 7152 C CA . LYS B 1 554 ? -45.930 -71.748 35.875 1.00 68.65 ? 527 LYS A CA 1 ATOM 7153 C C . LYS B 1 554 ? -45.064 -70.788 36.738 1.00 71.92 ? 527 LYS A C 1 ATOM 7154 O O . LYS B 1 554 ? -43.822 -70.883 36.687 1.00 71.87 ? 527 LYS A O 1 ATOM 7155 C CB . LYS B 1 554 ? -45.754 -71.466 34.374 1.00 66.87 ? 527 LYS A CB 1 ATOM 7156 N N . ILE B 1 555 ? -45.683 -69.923 37.559 1.00 68.66 ? 528 ILE A N 1 ATOM 7157 C CA . ILE B 1 555 ? -44.927 -68.889 38.333 1.00 70.55 ? 528 ILE A CA 1 ATOM 7158 C C . ILE B 1 555 ? -44.461 -69.377 39.687 1.00 63.35 ? 528 ILE A C 1 ATOM 7159 O O . ILE B 1 555 ? -45.267 -69.782 40.503 1.00 76.09 ? 528 ILE A O 1 ATOM 7160 C CB . ILE B 1 555 ? -45.754 -67.566 38.576 1.00 71.11 ? 528 ILE A CB 1 ATOM 7161 C CG1 . ILE B 1 555 ? -45.937 -66.776 37.276 1.00 71.69 ? 528 ILE A CG1 1 ATOM 7162 C CG2 . ILE B 1 555 ? -45.096 -66.629 39.593 1.00 63.36 ? 528 ILE A CG2 1 ATOM 7163 C CD1 . ILE B 1 555 ? -47.167 -65.893 37.287 1.00 71.54 ? 528 ILE A CD1 1 ATOM 7164 N N . LEU B 1 556 ? -43.167 -69.298 39.942 1.00 63.40 ? 529 LEU A N 1 ATOM 7165 C CA . LEU B 1 556 ? -42.649 -69.447 41.293 1.00 68.90 ? 529 LEU A CA 1 ATOM 7166 C C . LEU B 1 556 ? -42.393 -68.099 41.959 1.00 71.05 ? 529 LEU A C 1 ATOM 7167 O O . LEU B 1 556 ? -41.552 -67.302 41.486 1.00 75.73 ? 529 LEU A O 1 ATOM 7168 C CB . LEU B 1 556 ? -41.381 -70.299 41.272 1.00 78.65 ? 529 LEU A CB 1 ATOM 7169 C CG . LEU B 1 556 ? -41.552 -71.712 40.672 1.00 81.29 ? 529 LEU A CG 1 ATOM 7170 C CD1 . LEU B 1 556 ? -40.251 -72.478 40.874 1.00 83.79 ? 529 LEU A CD1 1 ATOM 7171 C CD2 . LEU B 1 556 ? -42.729 -72.486 41.284 1.00 74.36 ? 529 LEU A CD2 1 ATOM 7172 N N . TRP B 1 557 ? -43.060 -67.885 43.097 1.00 66.97 ? 530 TRP A N 1 ATOM 7173 C CA . TRP B 1 557 ? -43.278 -66.543 43.618 1.00 67.28 ? 530 TRP A CA 1 ATOM 7174 C C . TRP B 1 557 ? -42.135 -65.799 44.294 1.00 73.14 ? 530 TRP A C 1 ATOM 7175 O O . TRP B 1 557 ? -42.169 -64.573 44.392 1.00 98.25 ? 530 TRP A O 1 ATOM 7176 C CB . TRP B 1 557 ? -44.566 -66.471 44.440 1.00 62.84 ? 530 TRP A CB 1 ATOM 7177 C CG . TRP B 1 557 ? -45.730 -66.334 43.524 1.00 65.51 ? 530 TRP A CG 1 ATOM 7178 C CD1 . TRP B 1 557 ? -46.684 -67.261 43.267 1.00 65.15 ? 530 TRP A CD1 1 ATOM 7179 C CD2 . TRP B 1 557 ? -46.016 -65.218 42.684 1.00 63.83 ? 530 TRP A CD2 1 ATOM 7180 N NE1 . TRP B 1 557 ? -47.563 -66.790 42.331 1.00 61.76 ? 530 TRP A NE1 1 ATOM 7181 C CE2 . TRP B 1 557 ? -47.176 -65.534 41.958 1.00 63.07 ? 530 TRP A CE2 1 ATOM 7182 C CE3 . TRP B 1 557 ? -45.389 -63.983 42.462 1.00 66.33 ? 530 TRP A CE3 1 ATOM 7183 C CZ2 . TRP B 1 557 ? -47.739 -64.656 41.036 1.00 65.94 ? 530 TRP A CZ2 1 ATOM 7184 C CZ3 . TRP B 1 557 ? -45.928 -63.119 41.536 1.00 59.94 ? 530 TRP A CZ3 1 ATOM 7185 C CH2 . TRP B 1 557 ? -47.096 -63.456 40.839 1.00 67.99 ? 530 TRP A CH2 1 ATOM 7186 N N . SER B 1 558 ? -41.103 -66.465 44.737 1.00 69.27 ? 531 SER A N 1 ATOM 7187 C CA . SER B 1 558 ? -39.886 -65.692 44.992 1.00 68.78 ? 531 SER A CA 1 ATOM 7188 C C . SER B 1 558 ? -38.763 -66.524 44.465 1.00 72.44 ? 531 SER A C 1 ATOM 7189 O O . SER B 1 558 ? -37.688 -66.626 45.075 1.00 76.51 ? 531 SER A O 1 ATOM 7190 C CB . SER B 1 558 ? -39.726 -65.331 46.467 1.00 64.03 ? 531 SER A CB 1 ATOM 7191 O OG . SER B 1 558 ? -40.717 -64.393 46.827 1.00 58.09 ? 531 SER A OG 1 ATOM 7192 N N . GLY B 1 559 ? -39.052 -67.101 43.299 1.00 72.24 ? 532 GLY A N 1 ATOM 7193 C CA . GLY B 1 559 ? -38.187 -68.054 42.641 1.00 78.85 ? 532 GLY A CA 1 ATOM 7194 C C . GLY B 1 559 ? -38.542 -69.503 42.898 1.00 83.03 ? 532 GLY A C 1 ATOM 7195 O O . GLY B 1 559 ? -38.112 -70.375 42.133 1.00 90.78 ? 532 GLY A O 1 ATOM 7196 N N . PHE B 1 560 ? -39.322 -69.759 43.959 1.00 86.01 ? 533 PHE A N 1 ATOM 7197 C CA . PHE B 1 560 ? -39.544 -71.124 44.468 1.00 84.64 ? 533 PHE A CA 1 ATOM 7198 C C . PHE B 1 560 ? -40.990 -71.552 44.763 1.00 84.81 ? 533 PHE A C 1 ATOM 7199 O O . PHE B 1 560 ? -41.334 -72.715 44.528 1.00 92.19 ? 533 PHE A O 1 ATOM 7200 C CB . PHE B 1 560 ? -38.684 -71.355 45.722 1.00 86.15 ? 533 PHE A CB 1 ATOM 7201 C CG . PHE B 1 560 ? -39.038 -70.472 46.891 1.00 90.06 ? 533 PHE A CG 1 ATOM 7202 C CD1 . PHE B 1 560 ? -40.050 -70.847 47.799 1.00 85.65 ? 533 PHE A CD1 1 ATOM 7203 C CD2 . PHE B 1 560 ? -38.345 -69.279 47.112 1.00 90.33 ? 533 PHE A CD2 1 ATOM 7204 C CE1 . PHE B 1 560 ? -40.367 -70.040 48.885 1.00 82.16 ? 533 PHE A CE1 1 ATOM 7205 C CE2 . PHE B 1 560 ? -38.661 -68.462 48.200 1.00 90.53 ? 533 PHE A CE2 1 ATOM 7206 C CZ . PHE B 1 560 ? -39.673 -68.842 49.085 1.00 87.92 ? 533 PHE A CZ 1 ATOM 7207 N N . SER B 1 561 ? -41.822 -70.626 45.260 1.00 81.29 ? 534 SER A N 1 ATOM 7208 C CA . SER B 1 561 ? -43.142 -70.937 45.862 1.00 64.99 ? 534 SER A CA 1 ATOM 7209 C C . SER B 1 561 ? -44.309 -71.009 44.878 1.00 62.29 ? 534 SER A C 1 ATOM 7210 O O . SER B 1 561 ? -44.509 -70.081 44.111 1.00 63.07 ? 534 SER A O 1 ATOM 7211 C CB . SER B 1 561 ? -43.456 -69.880 46.910 1.00 64.43 ? 534 SER A CB 1 ATOM 7212 O OG . SER B 1 561 ? -44.774 -70.002 47.390 1.00 64.95 ? 534 SER A OG 1 ATOM 7213 N N . ARG B 1 562 ? -45.081 -72.110 44.901 1.00 66.85 ? 535 ARG A N 1 ATOM 7214 C CA . ARG B 1 562 ? -46.294 -72.242 44.070 1.00 60.25 ? 535 ARG A CA 1 ATOM 7215 C C . ARG B 1 562 ? -47.562 -71.811 44.857 1.00 58.94 ? 535 ARG A C 1 ATOM 7216 O O . ARG B 1 562 ? -48.650 -71.703 44.295 1.00 59.05 ? 535 ARG A O 1 ATOM 7217 C CB . ARG B 1 562 ? -46.406 -73.650 43.464 1.00 51.01 ? 535 ARG A CB 1 ATOM 7218 N N . GLU B 1 563 ? -47.402 -71.491 46.135 1.00 60.99 ? 536 GLU A N 1 ATOM 7219 C CA . GLU B 1 563 ? -48.523 -71.126 46.999 1.00 70.90 ? 536 GLU A CA 1 ATOM 7220 C C . GLU B 1 563 ? -48.695 -69.584 47.112 1.00 75.86 ? 536 GLU A C 1 ATOM 7221 O O . GLU B 1 563 ? -48.049 -68.957 47.941 1.00 73.13 ? 536 GLU A O 1 ATOM 7222 C CB . GLU B 1 563 ? -48.295 -71.752 48.383 1.00 69.36 ? 536 GLU A CB 1 ATOM 7223 N N . VAL B 1 564 ? -49.554 -68.980 46.281 1.00 77.45 ? 537 VAL A N 1 ATOM 7224 C CA . VAL B 1 564 ? -49.760 -67.507 46.281 1.00 75.50 ? 537 VAL A CA 1 ATOM 7225 C C . VAL B 1 564 ? -50.719 -66.994 47.392 1.00 69.35 ? 537 VAL A C 1 ATOM 7226 O O . VAL B 1 564 ? -51.732 -67.614 47.701 1.00 64.92 ? 537 VAL A O 1 ATOM 7227 C CB . VAL B 1 564 ? -50.230 -66.972 44.890 1.00 60.29 ? 537 VAL A CB 1 ATOM 7228 N N . PRO B 1 565 ? -50.388 -65.827 47.955 1.00 68.25 ? 538 PRO A N 1 ATOM 7229 C CA . PRO B 1 565 ? -50.645 -64.752 48.903 1.00 72.64 ? 538 PRO A CA 1 ATOM 7230 C C . PRO B 1 565 ? -49.568 -64.753 49.993 1.00 71.55 ? 538 PRO A C 1 ATOM 7231 O O . PRO B 1 565 ? -49.027 -65.819 50.329 1.00 65.57 ? 538 PRO A O 1 ATOM 7232 C CB . PRO B 1 565 ? -52.055 -65.070 49.434 1.00 68.87 ? 538 PRO A CB 1 HETATM 7233 GD GD . GD3 C 2 . ? -39.773 -31.315 47.816 1.00 107.06 ? 601 GD3 B GD 1 HETATM 7234 MG MG . MG D 3 . ? -49.912 -38.090 30.824 1.00 62.84 ? 602 MG B MG 1 HETATM 7235 MG MG . MG E 3 . ? -9.937 -5.720 26.937 1.00 77.41 ? 603 MG B MG 1 HETATM 7236 C C . BCT F 4 . ? -34.720 -10.503 28.114 1.00 56.51 ? 604 BCT B C 1 HETATM 7237 O O1 . BCT F 4 . ? -35.140 -11.094 27.098 1.00 57.47 ? 604 BCT B O1 1 HETATM 7238 O O2 . BCT F 4 . ? -35.164 -10.797 29.232 1.00 64.57 ? 604 BCT B O2 1 HETATM 7239 O O3 . BCT F 4 . ? -33.803 -9.539 28.041 1.00 45.12 ? 604 BCT B O3 1 HETATM 7240 CL CL . CL G 5 . ? -30.442 -21.189 20.727 1.00 71.17 ? 605 CL B CL 1 HETATM 7241 C C1 . NAG H 6 . ? -64.524 -35.634 25.637 1.00 105.01 ? 606 NAG B C1 1 HETATM 7242 C C2 . NAG H 6 . ? -63.931 -36.927 25.062 1.00 115.70 ? 606 NAG B C2 1 HETATM 7243 C C3 . NAG H 6 . ? -64.798 -37.347 23.883 1.00 122.49 ? 606 NAG B C3 1 HETATM 7244 C C4 . NAG H 6 . ? -66.204 -37.665 24.396 1.00 125.99 ? 606 NAG B C4 1 HETATM 7245 C C5 . NAG H 6 . ? -66.829 -36.439 25.096 1.00 121.79 ? 606 NAG B C5 1 HETATM 7246 C C6 . NAG H 6 . ? -68.067 -36.825 25.930 1.00 112.08 ? 606 NAG B C6 1 HETATM 7247 C C7 . NAG H 6 . ? -61.456 -37.060 25.376 1.00 106.92 ? 606 NAG B C7 1 HETATM 7248 C C8 . NAG H 6 . ? -60.119 -36.921 24.705 1.00 104.56 ? 606 NAG B C8 1 HETATM 7249 N N2 . NAG H 6 . ? -62.540 -36.831 24.607 1.00 112.31 ? 606 NAG B N2 1 HETATM 7250 O O3 . NAG H 6 . ? -64.211 -38.457 23.241 1.00 126.46 ? 606 NAG B O3 1 HETATM 7251 O O4 . NAG H 6 . ? -67.030 -38.108 23.335 1.00 108.21 ? 606 NAG B O4 1 HETATM 7252 O O5 . NAG H 6 . ? -65.917 -35.727 25.934 1.00 113.38 ? 606 NAG B O5 1 HETATM 7253 O O6 . NAG H 6 . ? -67.801 -36.795 27.323 1.00 88.70 ? 606 NAG B O6 1 HETATM 7254 O O7 . NAG H 6 . ? -61.474 -37.359 26.572 1.00 92.59 ? 606 NAG B O7 1 HETATM 7255 C C1 . NAG I 6 . ? -66.267 -16.434 23.927 1.00 113.87 ? 607 NAG B C1 1 HETATM 7256 C C2 . NAG I 6 . ? -67.226 -15.841 22.891 1.00 124.27 ? 607 NAG B C2 1 HETATM 7257 C C3 . NAG I 6 . ? -67.996 -14.643 23.438 1.00 131.87 ? 607 NAG B C3 1 HETATM 7258 C C4 . NAG I 6 . ? -68.542 -14.968 24.833 1.00 128.00 ? 607 NAG B C4 1 HETATM 7259 C C5 . NAG I 6 . ? -67.400 -15.438 25.743 1.00 123.13 ? 607 NAG B C5 1 HETATM 7260 C C6 . NAG I 6 . ? -67.826 -15.647 27.204 1.00 121.28 ? 607 NAG B C6 1 HETATM 7261 C C7 . NAG I 6 . ? -66.661 -16.082 20.518 1.00 123.03 ? 607 NAG B C7 1 HETATM 7262 C C8 . NAG I 6 . ? -65.762 -15.642 19.396 1.00 115.87 ? 607 NAG B C8 1 HETATM 7263 N N2 . NAG I 6 . ? -66.452 -15.500 21.705 1.00 120.37 ? 607 NAG B N2 1 HETATM 7264 O O3 . NAG I 6 . ? -69.046 -14.326 22.545 1.00 133.64 ? 607 NAG B O3 1 HETATM 7265 O O4 . NAG I 6 . ? -69.183 -13.840 25.390 1.00 121.23 ? 607 NAG B O4 1 HETATM 7266 O O5 . NAG I 6 . ? -66.859 -16.622 25.197 1.00 112.20 ? 607 NAG B O5 1 HETATM 7267 O O6 . NAG I 6 . ? -67.850 -17.008 27.581 1.00 109.21 ? 607 NAG B O6 1 HETATM 7268 O O7 . NAG I 6 . ? -67.539 -16.931 20.314 1.00 115.73 ? 607 NAG B O7 1 HETATM 7269 C C1 . NAG J 6 . ? -16.765 -15.386 46.954 1.00 59.22 ? 608 NAG B C1 1 HETATM 7270 C C2 . NAG J 6 . ? -16.803 -16.562 47.919 1.00 59.42 ? 608 NAG B C2 1 HETATM 7271 C C3 . NAG J 6 . ? -17.504 -16.140 49.222 1.00 68.35 ? 608 NAG B C3 1 HETATM 7272 C C4 . NAG J 6 . ? -16.783 -14.954 49.811 1.00 61.15 ? 608 NAG B C4 1 HETATM 7273 C C5 . NAG J 6 . ? -16.699 -13.828 48.807 1.00 62.71 ? 608 NAG B C5 1 HETATM 7274 C C6 . NAG J 6 . ? -15.931 -12.717 49.502 1.00 60.47 ? 608 NAG B C6 1 HETATM 7275 C C7 . NAG J 6 . ? -16.891 -18.941 47.287 1.00 72.29 ? 608 NAG B C7 1 HETATM 7276 C C8 . NAG J 6 . ? -17.723 -20.076 46.774 1.00 81.31 ? 608 NAG B C8 1 HETATM 7277 N N2 . NAG J 6 . ? -17.477 -17.740 47.409 1.00 62.85 ? 608 NAG B N2 1 HETATM 7278 O O3 . NAG J 6 . ? -17.611 -17.127 50.261 1.00 71.12 ? 608 NAG B O3 1 HETATM 7279 O O4 . NAG J 6 . ? -17.591 -14.500 50.853 1.00 63.73 ? 608 NAG B O4 1 HETATM 7280 O O5 . NAG J 6 . ? -16.137 -14.246 47.555 1.00 60.57 ? 608 NAG B O5 1 HETATM 7281 O O6 . NAG J 6 . ? -15.378 -11.903 48.506 1.00 69.12 ? 608 NAG B O6 1 HETATM 7282 O O7 . NAG J 6 . ? -15.719 -19.188 47.531 1.00 79.51 ? 608 NAG B O7 1 HETATM 7283 N N . TCR K 7 . ? -35.033 -22.676 29.569 1.00 47.51 ? 609 TCR B N 1 HETATM 7284 C CA . TCR K 7 . ? -35.772 -23.231 28.464 1.00 41.41 ? 609 TCR B CA 1 HETATM 7285 C CB . TCR K 7 . ? -35.638 -22.312 27.275 1.00 44.72 ? 609 TCR B CB 1 HETATM 7286 C CG . TCR K 7 . ? -35.927 -20.922 27.703 1.00 44.75 ? 609 TCR B CG 1 HETATM 7287 C CD2 . TCR K 7 . ? -36.476 -19.810 26.966 1.00 47.53 ? 609 TCR B CD2 1 HETATM 7288 C CE2 . TCR K 7 . ? -36.569 -18.696 27.926 1.00 46.96 ? 609 TCR B CE2 1 HETATM 7289 C CE3 . TCR K 7 . ? -36.822 -19.689 25.637 1.00 57.95 ? 609 TCR B CE3 1 HETATM 7290 C CD1 . TCR K 7 . ? -35.770 -20.423 29.057 1.00 49.41 ? 609 TCR B CD1 1 HETATM 7291 N NE1 . TCR K 7 . ? -36.137 -19.117 29.119 1.00 48.49 ? 609 TCR B NE1 1 HETATM 7292 C CZ2 . TCR K 7 . ? -37.041 -17.479 27.473 1.00 55.28 ? 609 TCR B CZ2 1 HETATM 7293 C CZ3 . TCR K 7 . ? -37.294 -18.431 25.222 1.00 63.54 ? 609 TCR B CZ3 1 HETATM 7294 C CH2 . TCR K 7 . ? -37.396 -17.348 26.120 1.00 58.60 ? 609 TCR B CH2 1 HETATM 7295 C C9 . TCR K 7 . ? -35.293 -21.358 30.148 1.00 53.36 ? 609 TCR B C9 1 HETATM 7296 C C . TCR K 7 . ? -35.034 -24.452 28.068 1.00 40.19 ? 609 TCR B C 1 HETATM 7297 O OXT . TCR K 7 . ? -34.110 -24.823 28.888 1.00 36.61 ? 609 TCR B OXT 1 HETATM 7298 O O1 . TCR K 7 . ? -35.341 -24.959 26.940 1.00 31.90 ? 609 TCR B O1 1 HETATM 7299 GD GD . GD3 L 2 . ? -53.196 -46.542 26.781 1.00 120.39 ? 601 GD3 A GD 1 HETATM 7300 MG MG . MG M 3 . ? -21.766 -60.370 -1.936 1.00 95.13 ? 602 MG A MG 1 HETATM 7301 C C . BCT N 4 . ? -28.715 -61.730 22.886 1.00 67.29 ? 603 BCT A C 1 HETATM 7302 O O1 . BCT N 4 . ? -29.256 -62.183 21.879 1.00 70.08 ? 603 BCT A O1 1 HETATM 7303 O O2 . BCT N 4 . ? -29.318 -61.246 23.899 1.00 61.27 ? 603 BCT A O2 1 HETATM 7304 O O3 . BCT N 4 . ? -27.414 -61.790 22.774 1.00 61.77 ? 603 BCT A O3 1 HETATM 7305 CL CL . CL O 5 . ? -23.126 -49.065 22.369 1.00 65.97 ? 604 CL A CL 1 HETATM 7306 C C1 . NAG P 6 . ? -36.709 -43.963 56.170 1.00 95.35 ? 605 NAG A C1 1 HETATM 7307 C C2 . NAG P 6 . ? -36.438 -42.459 56.014 1.00 105.56 ? 605 NAG A C2 1 HETATM 7308 C C3 . NAG P 6 . ? -35.539 -41.860 57.093 1.00 114.02 ? 605 NAG A C3 1 HETATM 7309 C C4 . NAG P 6 . ? -36.014 -42.294 58.471 1.00 121.12 ? 605 NAG A C4 1 HETATM 7310 C C5 . NAG P 6 . ? -36.011 -43.830 58.495 1.00 120.72 ? 605 NAG A C5 1 HETATM 7311 C C6 . NAG P 6 . ? -36.365 -44.404 59.869 1.00 113.01 ? 605 NAG A C6 1 HETATM 7312 C C7 . NAG P 6 . ? -36.570 -42.040 53.645 1.00 96.97 ? 605 NAG A C7 1 HETATM 7313 C C8 . NAG P 6 . ? -35.866 -41.774 52.347 1.00 100.00 ? 605 NAG A C8 1 HETATM 7314 N N2 . NAG P 6 . ? -35.833 -42.192 54.727 1.00 98.72 ? 605 NAG A N2 1 HETATM 7315 O O3 . NAG P 6 . ? -35.534 -40.456 56.978 1.00 108.43 ? 605 NAG A O3 1 HETATM 7316 O O4 . NAG P 6 . ? -35.142 -41.749 59.439 1.00 120.65 ? 605 NAG A O4 1 HETATM 7317 O O5 . NAG P 6 . ? -36.904 -44.359 57.516 1.00 110.93 ? 605 NAG A O5 1 HETATM 7318 O O6 . NAG P 6 . ? -37.765 -44.560 60.002 1.00 104.47 ? 605 NAG A O6 1 HETATM 7319 O O7 . NAG P 6 . ? -37.789 -42.124 53.688 1.00 97.62 ? 605 NAG A O7 1 HETATM 7320 C C1 . NAG Q 6 . ? -32.257 -61.990 56.009 1.00 119.09 ? 606 NAG A C1 1 HETATM 7321 C C2 . NAG Q 6 . ? -31.392 -62.927 56.841 1.00 124.50 ? 606 NAG A C2 1 HETATM 7322 C C3 . NAG Q 6 . ? -31.627 -64.309 56.268 1.00 127.84 ? 606 NAG A C3 1 HETATM 7323 C C4 . NAG Q 6 . ? -33.131 -64.630 56.261 1.00 134.08 ? 606 NAG A C4 1 HETATM 7324 C C5 . NAG Q 6 . ? -34.087 -63.433 56.059 1.00 137.23 ? 606 NAG A C5 1 HETATM 7325 C C6 . NAG Q 6 . ? -35.426 -63.677 56.757 1.00 141.85 ? 606 NAG A C6 1 HETATM 7326 C C7 . NAG Q 6 . ? -29.518 -61.580 57.641 1.00 109.28 ? 606 NAG A C7 1 HETATM 7327 C C8 . NAG Q 6 . ? -28.042 -61.285 57.612 1.00 112.42 ? 606 NAG A C8 1 HETATM 7328 N N2 . NAG Q 6 . ? -29.974 -62.574 56.873 1.00 114.16 ? 606 NAG A N2 1 HETATM 7329 O O3 . NAG Q 6 . ? -30.907 -65.223 57.061 1.00 128.84 ? 606 NAG A O3 1 HETATM 7330 O O4 . NAG Q 6 . ? -33.399 -65.545 55.220 1.00 132.11 ? 606 NAG A O4 1 HETATM 7331 O O5 . NAG Q 6 . ? -33.574 -62.171 56.469 1.00 122.16 ? 606 NAG A O5 1 HETATM 7332 O O6 . NAG Q 6 . ? -36.451 -63.034 56.025 1.00 144.44 ? 606 NAG A O6 1 HETATM 7333 O O7 . NAG Q 6 . ? -30.256 -60.901 58.353 1.00 93.79 ? 606 NAG A O7 1 HETATM 7334 C C1 . NAG R 6 . ? -44.204 -56.029 2.321 1.00 109.71 ? 607 NAG A C1 1 HETATM 7335 C C2 . NAG R 6 . ? -45.392 -55.116 2.674 1.00 111.28 ? 607 NAG A C2 1 HETATM 7336 C C3 . NAG R 6 . ? -46.674 -55.890 2.938 1.00 109.82 ? 607 NAG A C3 1 HETATM 7337 C C4 . NAG R 6 . ? -46.928 -57.004 1.933 1.00 107.62 ? 607 NAG A C4 1 HETATM 7338 C C5 . NAG R 6 . ? -45.673 -57.775 1.534 1.00 109.52 ? 607 NAG A C5 1 HETATM 7339 C C6 . NAG R 6 . ? -46.016 -58.650 0.324 1.00 101.74 ? 607 NAG A C6 1 HETATM 7340 C C7 . NAG R 6 . ? -45.147 -52.940 3.803 1.00 114.21 ? 607 NAG A C7 1 HETATM 7341 C C8 . NAG R 6 . ? -44.913 -52.203 5.094 1.00 112.78 ? 607 NAG A C8 1 HETATM 7342 N N2 . NAG R 6 . ? -45.169 -54.280 3.850 1.00 114.13 ? 607 NAG A N2 1 HETATM 7343 O O3 . NAG R 6 . ? -47.742 -54.973 2.881 1.00 113.31 ? 607 NAG A O3 1 HETATM 7344 O O4 . NAG R 6 . ? -47.807 -57.926 2.526 1.00 106.86 ? 607 NAG A O4 1 HETATM 7345 O O5 . NAG R 6 . ? -44.583 -56.905 1.262 1.00 113.12 ? 607 NAG A O5 1 HETATM 7346 O O6 . NAG R 6 . ? -44.873 -58.949 -0.436 1.00 89.47 ? 607 NAG A O6 1 HETATM 7347 O O7 . NAG R 6 . ? -45.298 -52.296 2.763 1.00 104.20 ? 607 NAG A O7 1 HETATM 7348 C C1 . NAG S 6 . ? -47.393 -62.218 17.784 1.00 96.66 ? 608 NAG A C1 1 HETATM 7349 C C2 . NAG S 6 . ? -46.858 -62.673 16.423 1.00 105.17 ? 608 NAG A C2 1 HETATM 7350 C C3 . NAG S 6 . ? -48.050 -63.057 15.571 1.00 114.06 ? 608 NAG A C3 1 HETATM 7351 C C4 . NAG S 6 . ? -48.708 -64.251 16.251 1.00 117.44 ? 608 NAG A C4 1 HETATM 7352 C C5 . NAG S 6 . ? -49.179 -63.878 17.651 1.00 108.00 ? 608 NAG A C5 1 HETATM 7353 C C6 . NAG S 6 . ? -49.654 -65.116 18.418 1.00 104.16 ? 608 NAG A C6 1 HETATM 7354 C C7 . NAG S 6 . ? -44.704 -61.543 15.821 1.00 116.32 ? 608 NAG A C7 1 HETATM 7355 C C8 . NAG S 6 . ? -43.848 -62.421 16.705 1.00 121.14 ? 608 NAG A C8 1 HETATM 7356 N N2 . NAG S 6 . ? -46.044 -61.685 15.728 1.00 106.41 ? 608 NAG A N2 1 HETATM 7357 O O3 . NAG S 6 . ? -47.653 -63.347 14.247 1.00 106.56 ? 608 NAG A O3 1 HETATM 7358 O O4 . NAG S 6 . ? -49.826 -64.640 15.501 1.00 134.89 ? 608 NAG A O4 1 HETATM 7359 O O5 . NAG S 6 . ? -48.133 -63.268 18.382 1.00 110.97 ? 608 NAG A O5 1 HETATM 7360 O O6 . NAG S 6 . ? -48.641 -65.628 19.264 1.00 98.37 ? 608 NAG A O6 1 HETATM 7361 O O7 . NAG S 6 . ? -44.122 -60.667 15.182 1.00 106.41 ? 608 NAG A O7 1 HETATM 7362 N N . TCR T 7 . ? -33.314 -50.751 25.301 1.00 40.63 ? 609 TCR A N 1 HETATM 7363 C CA . TCR T 7 . ? -32.165 -50.188 25.979 1.00 36.89 ? 609 TCR A CA 1 HETATM 7364 C CB . TCR T 7 . ? -30.823 -50.855 26.268 1.00 39.03 ? 609 TCR A CB 1 HETATM 7365 C CG . TCR T 7 . ? -31.050 -52.282 26.073 1.00 40.82 ? 609 TCR A CG 1 HETATM 7366 C CD2 . TCR T 7 . ? -30.218 -53.407 26.477 1.00 44.67 ? 609 TCR A CD2 1 HETATM 7367 C CE2 . TCR T 7 . ? -30.973 -54.629 26.071 1.00 46.00 ? 609 TCR A CE2 1 HETATM 7368 C CE3 . TCR T 7 . ? -28.997 -53.475 27.087 1.00 48.98 ? 609 TCR A CE3 1 HETATM 7369 C CD1 . TCR T 7 . ? -32.293 -52.902 25.533 1.00 45.30 ? 609 TCR A CD1 1 HETATM 7370 N NE1 . TCR T 7 . ? -32.163 -54.258 25.532 1.00 50.45 ? 609 TCR A NE1 1 HETATM 7371 C CZ2 . TCR T 7 . ? -30.415 -55.855 26.292 1.00 45.14 ? 609 TCR A CZ2 1 HETATM 7372 C CZ3 . TCR T 7 . ? -28.478 -54.763 27.294 1.00 55.14 ? 609 TCR A CZ3 1 HETATM 7373 C CH2 . TCR T 7 . ? -29.170 -55.938 26.901 1.00 48.72 ? 609 TCR A CH2 1 HETATM 7374 C C9 . TCR T 7 . ? -33.484 -52.152 25.032 1.00 42.45 ? 609 TCR A C9 1 HETATM 7375 C C . TCR T 7 . ? -31.997 -48.746 25.669 1.00 37.78 ? 609 TCR A C 1 HETATM 7376 O OXT . TCR T 7 . ? -31.149 -48.143 26.358 1.00 32.81 ? 609 TCR A OXT 1 HETATM 7377 O O1 . TCR T 7 . ? -32.637 -48.251 24.673 1.00 34.40 ? 609 TCR A O1 1 HETATM 7378 O O . HOH U 8 . ? -20.148 -4.666 13.246 1.00 61.96 ? 701 HOH B O 1 HETATM 7379 O O . HOH U 8 . ? -39.016 -24.106 21.555 1.00 61.41 ? 702 HOH B O 1 HETATM 7380 O O . HOH U 8 . ? -60.167 -16.022 30.272 1.00 48.86 ? 703 HOH B O 1 HETATM 7381 O O . HOH U 8 . ? -40.121 -26.163 25.249 1.00 41.69 ? 704 HOH B O 1 HETATM 7382 O O . HOH U 8 . ? -35.595 -29.809 34.752 1.00 42.87 ? 705 HOH B O 1 HETATM 7383 O O . HOH U 8 . ? -52.404 -38.317 31.255 1.00 48.17 ? 706 HOH B O 1 HETATM 7384 O O . HOH U 8 . ? -40.020 -11.879 16.978 1.00 49.78 ? 707 HOH B O 1 HETATM 7385 O O . HOH U 8 . ? -36.795 -36.018 29.382 1.00 48.09 ? 708 HOH B O 1 HETATM 7386 O O . HOH U 8 . ? -63.464 -22.436 33.407 1.00 60.95 ? 709 HOH B O 1 HETATM 7387 O O . HOH U 8 . ? -25.257 -2.006 17.436 1.00 51.67 ? 710 HOH B O 1 HETATM 7388 O O . HOH U 8 . ? -18.021 -27.974 34.614 1.00 71.51 ? 711 HOH B O 1 HETATM 7389 O O . HOH V 8 . ? -41.712 -39.918 20.423 1.00 47.40 ? 701 HOH A O 1 HETATM 7390 O O . HOH V 8 . ? -26.249 -56.428 31.480 1.00 43.77 ? 702 HOH A O 1 HETATM 7391 O O . HOH V 8 . ? -29.421 -33.113 13.806 1.00 37.54 ? 703 HOH A O 1 HETATM 7392 O O . HOH V 8 . ? -37.921 -53.603 -0.575 1.00 55.45 ? 704 HOH A O 1 HETATM 7393 O O . HOH V 8 . ? -25.447 -52.954 28.191 1.00 57.57 ? 705 HOH A O 1 HETATM 7394 O O . HOH V 8 . ? -40.524 -38.040 32.021 1.00 38.90 ? 706 HOH A O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 MET 1 -26 ? ? ? B . n A 1 2 ARG 2 -25 ? ? ? B . n A 1 3 LEU 3 -24 ? ? ? B . n A 1 4 LEU 4 -23 ? ? ? B . n A 1 5 THR 5 -22 ? ? ? B . n A 1 6 ALA 6 -21 ? ? ? B . n A 1 7 LEU 7 -20 ? ? ? B . n A 1 8 PHE 8 -19 ? ? ? B . n A 1 9 ALA 9 -18 ? ? ? B . n A 1 10 TYR 10 -17 ? ? ? B . n A 1 11 PHE 11 -16 ? ? ? B . n A 1 12 ILE 12 -15 ? ? ? B . n A 1 13 VAL 13 -14 ? ? ? B . n A 1 14 ALA 14 -13 ? ? ? B . n A 1 15 LEU 15 -12 ? ? ? B . n A 1 16 ILE 16 -11 ? ? ? B . n A 1 17 LEU 17 -10 ? ? ? B . n A 1 18 ALA 18 -9 ? ? ? B . n A 1 19 PHE 19 -8 ? ? ? B . n A 1 20 SER 20 -7 ? ? ? B . n A 1 21 VAL 21 -6 ? ? ? B . n A 1 22 SER 22 -5 ? ? ? B . n A 1 23 ALA 23 -4 ? ? ? B . n A 1 24 LYS 24 -3 ? ? ? B . n A 1 25 SER 25 -2 ? ? ? B . n A 1 26 MET 26 -1 ? ? ? B . n A 1 27 HIS 27 0 ? ? ? B . n A 1 28 HIS 28 1 ? ? ? B . n A 1 29 HIS 29 2 ? ? ? B . n A 1 30 HIS 30 3 ? ? ? B . n A 1 31 HIS 31 4 ? ? ? B . n A 1 32 HIS 32 5 ? ? ? B . n A 1 33 HIS 33 6 ? ? ? B . n A 1 34 HIS 34 7 ? ? ? B . n A 1 35 SER 35 8 ? ? ? B . n A 1 36 ALA 36 9 ? ? ? B . n A 1 37 TRP 37 10 ? ? ? B . n A 1 38 SER 38 11 ? ? ? B . n A 1 39 HIS 39 12 ? ? ? B . n A 1 40 PRO 40 13 ? ? ? B . n A 1 41 GLN 41 14 ? ? ? B . n A 1 42 PHE 42 15 ? ? ? B . n A 1 43 GLU 43 16 ? ? ? B . n A 1 44 LYS 44 17 ? ? ? B . n A 1 45 GLU 45 18 ? ? ? B . n A 1 46 PHE 46 19 ? ? ? B . n A 1 47 TYR 47 20 ? ? ? B . n A 1 48 GLY 48 21 21 GLY GLY B . n A 1 49 PRO 49 22 22 PRO PRO B . n A 1 50 ASP 50 23 23 ASP ASP B . n A 1 51 GLN 51 24 24 GLN GLN B . n A 1 52 ARG 52 25 25 ARG ARG B . n A 1 53 ALA 53 26 26 ALA ALA B . n A 1 54 GLN 54 27 27 GLN GLN B . n A 1 55 LYS 55 28 28 LYS LYS B . n A 1 56 LYS 56 29 29 LYS LYS B . n A 1 57 GLY 57 30 30 GLY GLY B . n A 1 58 ASP 58 31 31 ASP ASP B . n A 1 59 ILE 59 32 32 ILE ILE B . n A 1 60 ILE 60 33 33 ILE ILE B . n A 1 61 LEU 61 34 34 LEU LEU B . n A 1 62 GLY 62 35 35 GLY GLY B . n A 1 63 GLY 63 36 36 GLY GLY B . n A 1 64 LEU 64 37 37 LEU LEU B . n A 1 65 PHE 65 38 38 PHE PHE B . n A 1 66 PRO 66 39 39 PRO PRO B . n A 1 67 ILE 67 40 40 ILE ILE B . n A 1 68 HIS 68 41 41 HIS HIS B . n A 1 69 PHE 69 42 42 PHE PHE B . n A 1 70 GLY 70 43 43 GLY GLY B . n A 1 71 VAL 71 44 44 VAL VAL B . n A 1 72 ALA 72 45 45 ALA ALA B . n A 1 73 ALA 73 46 46 ALA ALA B . n A 1 74 LYS 74 47 47 LYS LYS B . n A 1 75 ASP 75 48 48 ASP ASP B . n A 1 76 GLN 76 49 49 GLN GLN B . n A 1 77 ASP 77 50 50 ASP ASP B . n A 1 78 LEU 78 51 51 LEU LEU B . n A 1 79 LYS 79 52 52 LYS LYS B . n A 1 80 SER 80 53 53 SER SER B . n A 1 81 ARG 81 54 54 ARG ARG B . n A 1 82 PRO 82 55 55 PRO PRO B . n A 1 83 GLU 83 56 56 GLU GLU B . n A 1 84 SER 84 57 57 SER SER B . n A 1 85 VAL 85 58 58 VAL VAL B . n A 1 86 GLU 86 59 59 GLU GLU B . n A 1 87 CYS 87 60 60 CYS CYS B . n A 1 88 ILE 88 61 61 ILE ILE B . n A 1 89 ARG 89 62 62 ARG ARG B . n A 1 90 TYR 90 63 63 TYR TYR B . n A 1 91 ASN 91 64 64 ASN ASN B . n A 1 92 PHE 92 65 65 PHE PHE B . n A 1 93 ARG 93 66 66 ARG ARG B . n A 1 94 GLY 94 67 67 GLY GLY B . n A 1 95 PHE 95 68 68 PHE PHE B . n A 1 96 ARG 96 69 69 ARG ARG B . n A 1 97 TRP 97 70 70 TRP TRP B . n A 1 98 LEU 98 71 71 LEU LEU B . n A 1 99 GLN 99 72 72 GLN GLN B . n A 1 100 ALA 100 73 73 ALA ALA B . n A 1 101 MET 101 74 74 MET MET B . n A 1 102 ILE 102 75 75 ILE ILE B . n A 1 103 PHE 103 76 76 PHE PHE B . n A 1 104 ALA 104 77 77 ALA ALA B . n A 1 105 ILE 105 78 78 ILE ILE B . n A 1 106 GLU 106 79 79 GLU GLU B . n A 1 107 GLU 107 80 80 GLU GLU B . n A 1 108 ILE 108 81 81 ILE ILE B . n A 1 109 ASN 109 82 82 ASN ASN B . n A 1 110 SER 110 83 83 SER SER B . n A 1 111 SER 111 84 84 SER SER B . n A 1 112 PRO 112 85 85 PRO PRO B . n A 1 113 ALA 113 86 86 ALA ALA B . n A 1 114 LEU 114 87 87 LEU LEU B . n A 1 115 LEU 115 88 88 LEU LEU B . n A 1 116 PRO 116 89 89 PRO PRO B . n A 1 117 ASN 117 90 90 ASN ASN B . n A 1 118 LEU 118 91 91 LEU LEU B . n A 1 119 THR 119 92 92 THR THR B . n A 1 120 LEU 120 93 93 LEU LEU B . n A 1 121 GLY 121 94 94 GLY GLY B . n A 1 122 TYR 122 95 95 TYR TYR B . n A 1 123 ARG 123 96 96 ARG ARG B . n A 1 124 ILE 124 97 97 ILE ILE B . n A 1 125 PHE 125 98 98 PHE PHE B . n A 1 126 ASP 126 99 99 ASP ASP B . n A 1 127 THR 127 100 100 THR THR B . n A 1 128 CYS 128 101 101 CYS CYS B . n A 1 129 ASN 129 102 102 ASN ASN B . n A 1 130 THR 130 103 103 THR THR B . n A 1 131 VAL 131 104 104 VAL VAL B . n A 1 132 SER 132 105 105 SER SER B . n A 1 133 LYS 133 106 106 LYS LYS B . n A 1 134 ALA 134 107 107 ALA ALA B . n A 1 135 LEU 135 108 108 LEU LEU B . n A 1 136 GLU 136 109 109 GLU GLU B . n A 1 137 ALA 137 110 110 ALA ALA B . n A 1 138 THR 138 111 111 THR THR B . n A 1 139 LEU 139 112 112 LEU LEU B . n A 1 140 SER 140 113 113 SER SER B . n A 1 141 PHE 141 114 114 PHE PHE B . n A 1 142 VAL 142 115 115 VAL VAL B . n A 1 143 ALA 143 116 116 ALA ALA B . n A 1 144 GLN 144 117 117 GLN GLN B . n A 1 145 ASN 145 118 118 ASN ASN B . n A 1 146 LYS 146 119 119 LYS LYS B . n A 1 147 ILE 147 120 120 ILE ILE B . n A 1 148 ASP 148 121 121 ASP ASP B . n A 1 149 SER 149 122 ? ? ? B . n A 1 150 LEU 150 123 ? ? ? B . n A 1 151 ASN 151 124 ? ? ? B . n A 1 152 LEU 152 125 ? ? ? B . n A 1 153 ASP 153 126 ? ? ? B . n A 1 154 GLU 154 127 ? ? ? B . n A 1 155 PHE 155 128 ? ? ? B . n A 1 156 CYS 156 129 ? ? ? B . n A 1 157 ASN 157 130 ? ? ? B . n A 1 158 CYS 158 131 ? ? ? B . n A 1 159 SER 159 132 ? ? ? B . n A 1 160 GLU 160 133 ? ? ? B . n A 1 161 HIS 161 134 ? ? ? B . n A 1 162 ILE 162 135 ? ? ? B . n A 1 163 PRO 163 136 ? ? ? B . n A 1 164 SER 164 137 137 SER SER B . n A 1 165 THR 165 138 138 THR THR B . n A 1 166 ILE 166 139 139 ILE ILE B . n A 1 167 ALA 167 140 140 ALA ALA B . n A 1 168 VAL 168 141 141 VAL VAL B . n A 1 169 VAL 169 142 142 VAL VAL B . n A 1 170 GLY 170 143 143 GLY GLY B . n A 1 171 ALA 171 144 144 ALA ALA B . n A 1 172 THR 172 145 145 THR THR B . n A 1 173 GLY 173 146 146 GLY GLY B . n A 1 174 SER 174 147 147 SER SER B . n A 1 175 GLY 175 148 148 GLY GLY B . n A 1 176 VAL 176 149 149 VAL VAL B . n A 1 177 SER 177 150 150 SER SER B . n A 1 178 THR 178 151 151 THR THR B . n A 1 179 ALA 179 152 152 ALA ALA B . n A 1 180 VAL 180 153 153 VAL VAL B . n A 1 181 ALA 181 154 154 ALA ALA B . n A 1 182 ASN 182 155 155 ASN ASN B . n A 1 183 LEU 183 156 156 LEU LEU B . n A 1 184 LEU 184 157 157 LEU LEU B . n A 1 185 GLY 185 158 158 GLY GLY B . n A 1 186 LEU 186 159 159 LEU LEU B . n A 1 187 PHE 187 160 160 PHE PHE B . n A 1 188 TYR 188 161 161 TYR TYR B . n A 1 189 ILE 189 162 162 ILE ILE B . n A 1 190 PRO 190 163 163 PRO PRO B . n A 1 191 GLN 191 164 164 GLN GLN B . n A 1 192 VAL 192 165 165 VAL VAL B . n A 1 193 SER 193 166 166 SER SER B . n A 1 194 TYR 194 167 167 TYR TYR B . n A 1 195 ALA 195 168 168 ALA ALA B . n A 1 196 SER 196 169 169 SER SER B . n A 1 197 SER 197 170 170 SER SER B . n A 1 198 SER 198 171 171 SER SER B . n A 1 199 ARG 199 172 172 ARG ARG B . n A 1 200 LEU 200 173 173 LEU LEU B . n A 1 201 LEU 201 174 174 LEU LEU B . n A 1 202 SER 202 175 175 SER SER B . n A 1 203 ASN 203 176 176 ASN ASN B . n A 1 204 LYS 204 177 177 LYS LYS B . n A 1 205 ASN 205 178 178 ASN ASN B . n A 1 206 GLN 206 179 179 GLN GLN B . n A 1 207 PHE 207 180 180 PHE PHE B . n A 1 208 LYS 208 181 181 LYS LYS B . n A 1 209 SER 209 182 182 SER SER B . n A 1 210 PHE 210 183 183 PHE PHE B . n A 1 211 LEU 211 184 184 LEU LEU B . n A 1 212 ARG 212 185 185 ARG ARG B . n A 1 213 THR 213 186 186 THR THR B . n A 1 214 ILE 214 187 187 ILE ILE B . n A 1 215 PRO 215 188 188 PRO PRO B . n A 1 216 ASN 216 189 189 ASN ASN B . n A 1 217 ASP 217 190 190 ASP ASP B . n A 1 218 GLU 218 191 191 GLU GLU B . n A 1 219 HIS 219 192 192 HIS HIS B . n A 1 220 GLN 220 193 193 GLN GLN B . n A 1 221 ALA 221 194 194 ALA ALA B . n A 1 222 THR 222 195 195 THR THR B . n A 1 223 ALA 223 196 196 ALA ALA B . n A 1 224 MET 224 197 197 MET MET B . n A 1 225 ALA 225 198 198 ALA ALA B . n A 1 226 ASP 226 199 199 ASP ASP B . n A 1 227 ILE 227 200 200 ILE ILE B . n A 1 228 ILE 228 201 201 ILE ILE B . n A 1 229 GLU 229 202 202 GLU GLU B . n A 1 230 TYR 230 203 203 TYR TYR B . n A 1 231 PHE 231 204 204 PHE PHE B . n A 1 232 ARG 232 205 205 ARG ARG B . n A 1 233 TRP 233 206 206 TRP TRP B . n A 1 234 ASN 234 207 207 ASN ASN B . n A 1 235 TRP 235 208 208 TRP TRP B . n A 1 236 VAL 236 209 209 VAL VAL B . n A 1 237 GLY 237 210 210 GLY GLY B . n A 1 238 THR 238 211 211 THR THR B . n A 1 239 ILE 239 212 212 ILE ILE B . n A 1 240 ALA 240 213 213 ALA ALA B . n A 1 241 ALA 241 214 214 ALA ALA B . n A 1 242 ASP 242 215 215 ASP ASP B . n A 1 243 ASP 243 216 216 ASP ASP B . n A 1 244 ASP 244 217 217 ASP ASP B . n A 1 245 TYR 245 218 218 TYR TYR B . n A 1 246 GLY 246 219 219 GLY GLY B . n A 1 247 ARG 247 220 220 ARG ARG B . n A 1 248 PRO 248 221 221 PRO PRO B . n A 1 249 GLY 249 222 222 GLY GLY B . n A 1 250 ILE 250 223 223 ILE ILE B . n A 1 251 GLU 251 224 224 GLU GLU B . n A 1 252 LYS 252 225 225 LYS LYS B . n A 1 253 PHE 253 226 226 PHE PHE B . n A 1 254 ARG 254 227 227 ARG ARG B . n A 1 255 GLU 255 228 228 GLU GLU B . n A 1 256 GLU 256 229 229 GLU GLU B . n A 1 257 ALA 257 230 230 ALA ALA B . n A 1 258 GLU 258 231 231 GLU GLU B . n A 1 259 GLU 259 232 232 GLU GLU B . n A 1 260 ARG 260 233 233 ARG ARG B . n A 1 261 ASP 261 234 234 ASP ASP B . n A 1 262 ILE 262 235 235 ILE ILE B . n A 1 263 CSO 263 236 236 CSO CSO B . n A 1 264 ILE 264 237 237 ILE ILE B . n A 1 265 ASP 265 238 238 ASP ASP B . n A 1 266 PHE 266 239 239 PHE PHE B . n A 1 267 SER 267 240 240 SER SER B . n A 1 268 GLU 268 241 241 GLU GLU B . n A 1 269 LEU 269 242 242 LEU LEU B . n A 1 270 ILE 270 243 243 ILE ILE B . n A 1 271 SER 271 244 244 SER SER B . n A 1 272 GLN 272 245 245 GLN GLN B . n A 1 273 TYR 273 246 246 TYR TYR B . n A 1 274 SER 274 247 247 SER SER B . n A 1 275 ASP 275 248 248 ASP ASP B . n A 1 276 GLU 276 249 249 GLU GLU B . n A 1 277 GLU 277 250 250 GLU GLU B . n A 1 278 GLU 278 251 251 GLU GLU B . n A 1 279 ILE 279 252 252 ILE ILE B . n A 1 280 GLN 280 253 253 GLN GLN B . n A 1 281 HIS 281 254 254 HIS HIS B . n A 1 282 VAL 282 255 255 VAL VAL B . n A 1 283 VAL 283 256 256 VAL VAL B . n A 1 284 GLU 284 257 257 GLU GLU B . n A 1 285 VAL 285 258 258 VAL VAL B . n A 1 286 ILE 286 259 259 ILE ILE B . n A 1 287 GLN 287 260 260 GLN GLN B . n A 1 288 ASN 288 261 261 ASN ASN B . n A 1 289 SER 289 262 262 SER SER B . n A 1 290 THR 290 263 263 THR THR B . n A 1 291 ALA 291 264 264 ALA ALA B . n A 1 292 LYS 292 265 265 LYS LYS B . n A 1 293 VAL 293 266 266 VAL VAL B . n A 1 294 ILE 294 267 267 ILE ILE B . n A 1 295 VAL 295 268 268 VAL VAL B . n A 1 296 VAL 296 269 269 VAL VAL B . n A 1 297 PHE 297 270 270 PHE PHE B . n A 1 298 SER 298 271 271 SER SER B . n A 1 299 SER 299 272 272 SER SER B . n A 1 300 GLY 300 273 273 GLY GLY B . n A 1 301 PRO 301 274 274 PRO PRO B . n A 1 302 ASP 302 275 275 ASP ASP B . n A 1 303 LEU 303 276 276 LEU LEU B . n A 1 304 GLU 304 277 277 GLU GLU B . n A 1 305 PRO 305 278 278 PRO PRO B . n A 1 306 LEU 306 279 279 LEU LEU B . n A 1 307 ILE 307 280 280 ILE ILE B . n A 1 308 LYS 308 281 281 LYS LYS B . n A 1 309 GLU 309 282 282 GLU GLU B . n A 1 310 ILE 310 283 283 ILE ILE B . n A 1 311 VAL 311 284 284 VAL VAL B . n A 1 312 ARG 312 285 285 ARG ARG B . n A 1 313 ARG 313 286 286 ARG ARG B . n A 1 314 ASN 314 287 287 ASN ASN B . n A 1 315 ILE 315 288 288 ILE ILE B . n A 1 316 THR 316 289 289 THR THR B . n A 1 317 GLY 317 290 290 GLY GLY B . n A 1 318 LYS 318 291 291 LYS LYS B . n A 1 319 ILE 319 292 292 ILE ILE B . n A 1 320 TRP 320 293 293 TRP TRP B . n A 1 321 LEU 321 294 294 LEU LEU B . n A 1 322 ALA 322 295 295 ALA ALA B . n A 1 323 SER 323 296 296 SER SER B . n A 1 324 GLU 324 297 297 GLU GLU B . n A 1 325 ALA 325 298 298 ALA ALA B . n A 1 326 TRP 326 299 299 TRP TRP B . n A 1 327 ALA 327 300 300 ALA ALA B . n A 1 328 SER 328 301 301 SER SER B . n A 1 329 SER 329 302 302 SER SER B . n A 1 330 SER 330 303 303 SER SER B . n A 1 331 LEU 331 304 304 LEU LEU B . n A 1 332 ILE 332 305 305 ILE ILE B . n A 1 333 ALA 333 306 306 ALA ALA B . n A 1 334 MET 334 307 307 MET MET B . n A 1 335 PRO 335 308 308 PRO PRO B . n A 1 336 GLN 336 309 309 GLN GLN B . n A 1 337 TYR 337 310 310 TYR TYR B . n A 1 338 PHE 338 311 311 PHE PHE B . n A 1 339 HIS 339 312 312 HIS HIS B . n A 1 340 VAL 340 313 313 VAL VAL B . n A 1 341 VAL 341 314 314 VAL VAL B . n A 1 342 GLY 342 315 315 GLY GLY B . n A 1 343 GLY 343 316 316 GLY GLY B . n A 1 344 THR 344 317 317 THR THR B . n A 1 345 ILE 345 318 318 ILE ILE B . n A 1 346 GLY 346 319 319 GLY GLY B . n A 1 347 PHE 347 320 320 PHE PHE B . n A 1 348 ALA 348 321 321 ALA ALA B . n A 1 349 LEU 349 322 322 LEU LEU B . n A 1 350 LYS 350 323 323 LYS LYS B . n A 1 351 ALA 351 324 324 ALA ALA B . n A 1 352 GLY 352 325 325 GLY GLY B . n A 1 353 GLN 353 326 326 GLN GLN B . n A 1 354 ILE 354 327 327 ILE ILE B . n A 1 355 PRO 355 328 328 PRO PRO B . n A 1 356 GLY 356 329 329 GLY GLY B . n A 1 357 PHE 357 330 330 PHE PHE B . n A 1 358 ARG 358 331 331 ARG ARG B . n A 1 359 GLU 359 332 332 GLU GLU B . n A 1 360 PHE 360 333 333 PHE PHE B . n A 1 361 LEU 361 334 334 LEU LEU B . n A 1 362 LYS 362 335 335 LYS LYS B . n A 1 363 LYS 363 336 336 LYS LYS B . n A 1 364 VAL 364 337 337 VAL VAL B . n A 1 365 HIS 365 338 338 HIS HIS B . n A 1 366 PRO 366 339 339 PRO PRO B . n A 1 367 ARG 367 340 340 ARG ARG B . n A 1 368 LYS 368 341 341 LYS LYS B . n A 1 369 SER 369 342 342 SER SER B . n A 1 370 VAL 370 343 343 VAL VAL B . n A 1 371 HIS 371 344 344 HIS HIS B . n A 1 372 ASN 372 345 345 ASN ASN B . n A 1 373 GLY 373 346 346 GLY GLY B . n A 1 374 PHE 374 347 347 PHE PHE B . n A 1 375 ALA 375 348 348 ALA ALA B . n A 1 376 LYS 376 349 349 LYS LYS B . n A 1 377 GLU 377 350 350 GLU GLU B . n A 1 378 PHE 378 351 351 PHE PHE B . n A 1 379 TRP 379 352 352 TRP TRP B . n A 1 380 GLU 380 353 353 GLU GLU B . n A 1 381 GLU 381 354 354 GLU GLU B . n A 1 382 THR 382 355 355 THR THR B . n A 1 383 PHE 383 356 356 PHE PHE B . n A 1 384 ASN 384 357 357 ASN ASN B . n A 1 385 CYS 385 358 358 CYS CYS B . n A 1 386 HIS 386 359 359 HIS HIS B . n A 1 387 LEU 387 360 360 LEU LEU B . n A 1 388 GLN 388 361 361 GLN GLN B . n A 1 389 GLU 389 362 ? ? ? B . n A 1 390 GLY 390 363 ? ? ? B . n A 1 391 ALA 391 364 ? ? ? B . n A 1 392 LYS 392 365 ? ? ? B . n A 1 393 GLY 393 366 ? ? ? B . n A 1 394 PRO 394 367 ? ? ? B . n A 1 395 LEU 395 368 ? ? ? B . n A 1 396 PRO 396 369 ? ? ? B . n A 1 397 VAL 397 370 ? ? ? B . n A 1 398 ASP 398 371 ? ? ? B . n A 1 399 THR 399 372 ? ? ? B . n A 1 400 PHE 400 373 ? ? ? B . n A 1 401 LEU 401 374 ? ? ? B . n A 1 402 ARG 402 375 ? ? ? B . n A 1 403 GLY 403 376 ? ? ? B . n A 1 404 HIS 404 377 ? ? ? B . n A 1 405 GLU 405 378 ? ? ? B . n A 1 406 GLU 406 379 ? ? ? B . n A 1 407 SER 407 380 ? ? ? B . n A 1 408 GLY 408 381 ? ? ? B . n A 1 409 ASP 409 382 ? ? ? B . n A 1 410 ARG 410 383 ? ? ? B . n A 1 411 PHE 411 384 ? ? ? B . n A 1 412 SER 412 385 ? ? ? B . n A 1 413 ASN 413 386 ? ? ? B . n A 1 414 SER 414 387 ? ? ? B . n A 1 415 SER 415 388 ? ? ? B . n A 1 416 THR 416 389 ? ? ? B . n A 1 417 ALA 417 390 ? ? ? B . n A 1 418 PHE 418 391 391 PHE PHE B . n A 1 419 ARG 419 392 392 ARG ARG B . n A 1 420 PRO 420 393 393 PRO PRO B . n A 1 421 LEU 421 394 394 LEU LEU B . n A 1 422 CYS 422 395 395 CYS CYS B . n A 1 423 THR 423 396 396 THR THR B . n A 1 424 GLY 424 397 397 GLY GLY B . n A 1 425 ASP 425 398 398 ASP ASP B . n A 1 426 GLU 426 399 399 GLU GLU B . n A 1 427 ASN 427 400 400 ASN ASN B . n A 1 428 ILE 428 401 401 ILE ILE B . n A 1 429 SER 429 402 402 SER SER B . n A 1 430 SER 430 403 403 SER SER B . n A 1 431 VAL 431 404 404 VAL VAL B . n A 1 432 GLU 432 405 405 GLU GLU B . n A 1 433 THR 433 406 406 THR THR B . n A 1 434 PRO 434 407 407 PRO PRO B . n A 1 435 TYR 435 408 408 TYR TYR B . n A 1 436 ILE 436 409 409 ILE ILE B . n A 1 437 ASP 437 410 410 ASP ASP B . n A 1 438 TYR 438 411 411 TYR TYR B . n A 1 439 THR 439 412 412 THR THR B . n A 1 440 HIS 440 413 413 HIS HIS B . n A 1 441 LEU 441 414 414 LEU LEU B . n A 1 442 ARG 442 415 415 ARG ARG B . n A 1 443 ILE 443 416 416 ILE ILE B . n A 1 444 SER 444 417 417 SER SER B . n A 1 445 TYR 445 418 418 TYR TYR B . n A 1 446 ASN 446 419 419 ASN ASN B . n A 1 447 VAL 447 420 420 VAL VAL B . n A 1 448 TYR 448 421 421 TYR TYR B . n A 1 449 LEU 449 422 422 LEU LEU B . n A 1 450 ALA 450 423 423 ALA ALA B . n A 1 451 VAL 451 424 424 VAL VAL B . n A 1 452 TYR 452 425 425 TYR TYR B . n A 1 453 SER 453 426 426 SER SER B . n A 1 454 ILE 454 427 427 ILE ILE B . n A 1 455 ALA 455 428 428 ALA ALA B . n A 1 456 HIS 456 429 429 HIS HIS B . n A 1 457 ALA 457 430 430 ALA ALA B . n A 1 458 LEU 458 431 431 LEU LEU B . n A 1 459 GLN 459 432 432 GLN GLN B . n A 1 460 ASP 460 433 433 ASP ASP B . n A 1 461 ILE 461 434 434 ILE ILE B . n A 1 462 TYR 462 435 435 TYR TYR B . n A 1 463 THR 463 436 436 THR THR B . n A 1 464 CYS 464 437 437 CYS CYS B . n A 1 465 LEU 465 438 438 LEU LEU B . n A 1 466 PRO 466 439 439 PRO PRO B . n A 1 467 GLY 467 440 440 GLY GLY B . n A 1 468 ARG 468 441 441 ARG ARG B . n A 1 469 GLY 469 442 442 GLY GLY B . n A 1 470 LEU 470 443 443 LEU LEU B . n A 1 471 PHE 471 444 444 PHE PHE B . n A 1 472 THR 472 445 445 THR THR B . n A 1 473 ASN 473 446 446 ASN ASN B . n A 1 474 GLY 474 447 447 GLY GLY B . n A 1 475 SER 475 448 448 SER SER B . n A 1 476 CYS 476 449 449 CYS CYS B . n A 1 477 ALA 477 450 450 ALA ALA B . n A 1 478 ASP 478 451 451 ASP ASP B . n A 1 479 ILE 479 452 452 ILE ILE B . n A 1 480 LYS 480 453 453 LYS LYS B . n A 1 481 LYS 481 454 454 LYS LYS B . n A 1 482 VAL 482 455 455 VAL VAL B . n A 1 483 GLU 483 456 456 GLU GLU B . n A 1 484 ALA 484 457 457 ALA ALA B . n A 1 485 TRP 485 458 458 TRP TRP B . n A 1 486 GLN 486 459 459 GLN GLN B . n A 1 487 VAL 487 460 460 VAL VAL B . n A 1 488 LEU 488 461 461 LEU LEU B . n A 1 489 LYS 489 462 462 LYS LYS B . n A 1 490 HIS 490 463 463 HIS HIS B . n A 1 491 LEU 491 464 464 LEU LEU B . n A 1 492 ARG 492 465 465 ARG ARG B . n A 1 493 HIS 493 466 466 HIS HIS B . n A 1 494 LEU 494 467 467 LEU LEU B . n A 1 495 ASN 495 468 468 ASN ASN B . n A 1 496 PHE 496 469 469 PHE PHE B . n A 1 497 THR 497 470 470 THR THR B . n A 1 498 ASN 498 471 471 ASN ASN B . n A 1 499 ASN 499 472 472 ASN ASN B . n A 1 500 MET 500 473 473 MET MET B . n A 1 501 GLY 501 474 474 GLY GLY B . n A 1 502 GLU 502 475 475 GLU GLU B . n A 1 503 GLN 503 476 476 GLN GLN B . n A 1 504 VAL 504 477 477 VAL VAL B . n A 1 505 THR 505 478 478 THR THR B . n A 1 506 PHE 506 479 479 PHE PHE B . n A 1 507 ASP 507 480 480 ASP ASP B . n A 1 508 GLU 508 481 481 GLU GLU B . n A 1 509 CSO 509 482 482 CSO CSO B . n A 1 510 GLY 510 483 483 GLY GLY B . n A 1 511 ASP 511 484 484 ASP ASP B . n A 1 512 LEU 512 485 485 LEU LEU B . n A 1 513 VAL 513 486 486 VAL VAL B . n A 1 514 GLY 514 487 487 GLY GLY B . n A 1 515 ASN 515 488 488 ASN ASN B . n A 1 516 TYR 516 489 489 TYR TYR B . n A 1 517 SER 517 490 490 SER SER B . n A 1 518 ILE 518 491 491 ILE ILE B . n A 1 519 ILE 519 492 492 ILE ILE B . n A 1 520 ASN 520 493 493 ASN ASN B . n A 1 521 TRP 521 494 494 TRP TRP B . n A 1 522 HIS 522 495 495 HIS HIS B . n A 1 523 LEU 523 496 496 LEU LEU B . n A 1 524 SER 524 497 497 SER SER B . n A 1 525 PRO 525 498 498 PRO PRO B . n A 1 526 GLU 526 499 499 GLU GLU B . n A 1 527 ASP 527 500 500 ASP ASP B . n A 1 528 GLY 528 501 501 GLY GLY B . n A 1 529 SER 529 502 502 SER SER B . n A 1 530 ILE 530 503 503 ILE ILE B . n A 1 531 VAL 531 504 504 VAL VAL B . n A 1 532 PHE 532 505 505 PHE PHE B . n A 1 533 LYS 533 506 506 LYS LYS B . n A 1 534 GLU 534 507 507 GLU GLU B . n A 1 535 VAL 535 508 508 VAL VAL B . n A 1 536 GLY 536 509 509 GLY GLY B . n A 1 537 TYR 537 510 510 TYR TYR B . n A 1 538 TYR 538 511 511 TYR TYR B . n A 1 539 ASN 539 512 512 ASN ASN B . n A 1 540 VAL 540 513 513 VAL VAL B . n A 1 541 TYR 541 514 514 TYR TYR B . n A 1 542 ALA 542 515 515 ALA ALA B . n A 1 543 LYS 543 516 516 LYS LYS B . n A 1 544 LYS 544 517 517 LYS LYS B . n A 1 545 GLY 545 518 518 GLY GLY B . n A 1 546 GLU 546 519 519 GLU GLU B . n A 1 547 ARG 547 520 520 ARG ARG B . n A 1 548 LEU 548 521 521 LEU LEU B . n A 1 549 PHE 549 522 522 PHE PHE B . n A 1 550 ILE 550 523 523 ILE ILE B . n A 1 551 ASN 551 524 524 ASN ASN B . n A 1 552 GLU 552 525 525 GLU GLU B . n A 1 553 GLU 553 526 526 GLU GLU B . n A 1 554 LYS 554 527 527 LYS LYS B . n A 1 555 ILE 555 528 528 ILE ILE B . n A 1 556 LEU 556 529 529 LEU LEU B . n A 1 557 TRP 557 530 530 TRP TRP B . n A 1 558 SER 558 531 531 SER SER B . n A 1 559 GLY 559 532 532 GLY GLY B . n A 1 560 PHE 560 533 533 PHE PHE B . n A 1 561 SER 561 534 534 SER SER B . n A 1 562 ARG 562 535 ? ? ? B . n A 1 563 GLU 563 536 ? ? ? B . n A 1 564 VAL 564 537 ? ? ? B . n A 1 565 PRO 565 538 ? ? ? B . n A 1 566 PHE 566 539 ? ? ? B . n A 1 567 SER 567 540 ? ? ? B . n A 1 568 ASN 568 541 ? ? ? B . n B 1 1 MET 1 -26 ? ? ? A . n B 1 2 ARG 2 -25 ? ? ? A . n B 1 3 LEU 3 -24 ? ? ? A . n B 1 4 LEU 4 -23 ? ? ? A . n B 1 5 THR 5 -22 ? ? ? A . n B 1 6 ALA 6 -21 ? ? ? A . n B 1 7 LEU 7 -20 ? ? ? A . n B 1 8 PHE 8 -19 ? ? ? A . n B 1 9 ALA 9 -18 ? ? ? A . n B 1 10 TYR 10 -17 ? ? ? A . n B 1 11 PHE 11 -16 ? ? ? A . n B 1 12 ILE 12 -15 ? ? ? A . n B 1 13 VAL 13 -14 ? ? ? A . n B 1 14 ALA 14 -13 ? ? ? A . n B 1 15 LEU 15 -12 ? ? ? A . n B 1 16 ILE 16 -11 ? ? ? A . n B 1 17 LEU 17 -10 ? ? ? A . n B 1 18 ALA 18 -9 ? ? ? A . n B 1 19 PHE 19 -8 ? ? ? A . n B 1 20 SER 20 -7 ? ? ? A . n B 1 21 VAL 21 -6 ? ? ? A . n B 1 22 SER 22 -5 ? ? ? A . n B 1 23 ALA 23 -4 ? ? ? A . n B 1 24 LYS 24 -3 ? ? ? A . n B 1 25 SER 25 -2 ? ? ? A . n B 1 26 MET 26 -1 ? ? ? A . n B 1 27 HIS 27 0 ? ? ? A . n B 1 28 HIS 28 1 ? ? ? A . n B 1 29 HIS 29 2 ? ? ? A . n B 1 30 HIS 30 3 ? ? ? A . n B 1 31 HIS 31 4 ? ? ? A . n B 1 32 HIS 32 5 ? ? ? A . n B 1 33 HIS 33 6 ? ? ? A . n B 1 34 HIS 34 7 ? ? ? A . n B 1 35 SER 35 8 ? ? ? A . n B 1 36 ALA 36 9 ? ? ? A . n B 1 37 TRP 37 10 ? ? ? A . n B 1 38 SER 38 11 ? ? ? A . n B 1 39 HIS 39 12 ? ? ? A . n B 1 40 PRO 40 13 ? ? ? A . n B 1 41 GLN 41 14 ? ? ? A . n B 1 42 PHE 42 15 ? ? ? A . n B 1 43 GLU 43 16 ? ? ? A . n B 1 44 LYS 44 17 ? ? ? A . n B 1 45 GLU 45 18 ? ? ? A . n B 1 46 PHE 46 19 ? ? ? A . n B 1 47 TYR 47 20 ? ? ? A . n B 1 48 GLY 48 21 ? ? ? A . n B 1 49 PRO 49 22 22 PRO PRO A . n B 1 50 ASP 50 23 23 ASP ASP A . n B 1 51 GLN 51 24 24 GLN GLN A . n B 1 52 ARG 52 25 25 ARG ARG A . n B 1 53 ALA 53 26 26 ALA ALA A . n B 1 54 GLN 54 27 27 GLN GLN A . n B 1 55 LYS 55 28 28 LYS LYS A . n B 1 56 LYS 56 29 29 LYS LYS A . n B 1 57 GLY 57 30 30 GLY GLY A . n B 1 58 ASP 58 31 31 ASP ASP A . n B 1 59 ILE 59 32 32 ILE ILE A . n B 1 60 ILE 60 33 33 ILE ILE A . n B 1 61 LEU 61 34 34 LEU LEU A . n B 1 62 GLY 62 35 35 GLY GLY A . n B 1 63 GLY 63 36 36 GLY GLY A . n B 1 64 LEU 64 37 37 LEU LEU A . n B 1 65 PHE 65 38 38 PHE PHE A . n B 1 66 PRO 66 39 39 PRO PRO A . n B 1 67 ILE 67 40 40 ILE ILE A . n B 1 68 HIS 68 41 41 HIS HIS A . n B 1 69 PHE 69 42 42 PHE PHE A . n B 1 70 GLY 70 43 43 GLY GLY A . n B 1 71 VAL 71 44 44 VAL VAL A . n B 1 72 ALA 72 45 45 ALA ALA A . n B 1 73 ALA 73 46 46 ALA ALA A . n B 1 74 LYS 74 47 47 LYS LYS A . n B 1 75 ASP 75 48 48 ASP ASP A . n B 1 76 GLN 76 49 49 GLN GLN A . n B 1 77 ASP 77 50 50 ASP ASP A . n B 1 78 LEU 78 51 51 LEU LEU A . n B 1 79 LYS 79 52 52 LYS LYS A . n B 1 80 SER 80 53 53 SER SER A . n B 1 81 ARG 81 54 54 ARG ARG A . n B 1 82 PRO 82 55 55 PRO PRO A . n B 1 83 GLU 83 56 56 GLU GLU A . n B 1 84 SER 84 57 57 SER SER A . n B 1 85 VAL 85 58 58 VAL VAL A . n B 1 86 GLU 86 59 59 GLU GLU A . n B 1 87 CYS 87 60 60 CYS CYS A . n B 1 88 ILE 88 61 61 ILE ILE A . n B 1 89 ARG 89 62 62 ARG ARG A . n B 1 90 TYR 90 63 63 TYR TYR A . n B 1 91 ASN 91 64 64 ASN ASN A . n B 1 92 PHE 92 65 65 PHE PHE A . n B 1 93 ARG 93 66 66 ARG ARG A . n B 1 94 GLY 94 67 67 GLY GLY A . n B 1 95 PHE 95 68 68 PHE PHE A . n B 1 96 ARG 96 69 69 ARG ARG A . n B 1 97 TRP 97 70 70 TRP TRP A . n B 1 98 LEU 98 71 71 LEU LEU A . n B 1 99 GLN 99 72 72 GLN GLN A . n B 1 100 ALA 100 73 73 ALA ALA A . n B 1 101 MET 101 74 74 MET MET A . n B 1 102 ILE 102 75 75 ILE ILE A . n B 1 103 PHE 103 76 76 PHE PHE A . n B 1 104 ALA 104 77 77 ALA ALA A . n B 1 105 ILE 105 78 78 ILE ILE A . n B 1 106 GLU 106 79 79 GLU GLU A . n B 1 107 GLU 107 80 80 GLU GLU A . n B 1 108 ILE 108 81 81 ILE ILE A . n B 1 109 ASN 109 82 82 ASN ASN A . n B 1 110 SER 110 83 83 SER SER A . n B 1 111 SER 111 84 84 SER SER A . n B 1 112 PRO 112 85 85 PRO PRO A . n B 1 113 ALA 113 86 86 ALA ALA A . n B 1 114 LEU 114 87 87 LEU LEU A . n B 1 115 LEU 115 88 88 LEU LEU A . n B 1 116 PRO 116 89 89 PRO PRO A . n B 1 117 ASN 117 90 90 ASN ASN A . n B 1 118 LEU 118 91 91 LEU LEU A . n B 1 119 THR 119 92 92 THR THR A . n B 1 120 LEU 120 93 93 LEU LEU A . n B 1 121 GLY 121 94 94 GLY GLY A . n B 1 122 TYR 122 95 95 TYR TYR A . n B 1 123 ARG 123 96 96 ARG ARG A . n B 1 124 ILE 124 97 97 ILE ILE A . n B 1 125 PHE 125 98 98 PHE PHE A . n B 1 126 ASP 126 99 99 ASP ASP A . n B 1 127 THR 127 100 100 THR THR A . n B 1 128 CYS 128 101 101 CYS CYS A . n B 1 129 ASN 129 102 102 ASN ASN A . n B 1 130 THR 130 103 103 THR THR A . n B 1 131 VAL 131 104 104 VAL VAL A . n B 1 132 SER 132 105 105 SER SER A . n B 1 133 LYS 133 106 106 LYS LYS A . n B 1 134 ALA 134 107 107 ALA ALA A . n B 1 135 LEU 135 108 108 LEU LEU A . n B 1 136 GLU 136 109 109 GLU GLU A . n B 1 137 ALA 137 110 110 ALA ALA A . n B 1 138 THR 138 111 111 THR THR A . n B 1 139 LEU 139 112 112 LEU LEU A . n B 1 140 SER 140 113 113 SER SER A . n B 1 141 PHE 141 114 114 PHE PHE A . n B 1 142 VAL 142 115 115 VAL VAL A . n B 1 143 ALA 143 116 116 ALA ALA A . n B 1 144 GLN 144 117 117 GLN GLN A . n B 1 145 ASN 145 118 118 ASN ASN A . n B 1 146 LYS 146 119 119 LYS LYS A . n B 1 147 ILE 147 120 120 ILE ILE A . n B 1 148 ASP 148 121 121 ASP ASP A . n B 1 149 SER 149 122 ? ? ? A . n B 1 150 LEU 150 123 ? ? ? A . n B 1 151 ASN 151 124 ? ? ? A . n B 1 152 LEU 152 125 ? ? ? A . n B 1 153 ASP 153 126 ? ? ? A . n B 1 154 GLU 154 127 ? ? ? A . n B 1 155 PHE 155 128 ? ? ? A . n B 1 156 CYS 156 129 ? ? ? A . n B 1 157 ASN 157 130 ? ? ? A . n B 1 158 CYS 158 131 ? ? ? A . n B 1 159 SER 159 132 ? ? ? A . n B 1 160 GLU 160 133 ? ? ? A . n B 1 161 HIS 161 134 ? ? ? A . n B 1 162 ILE 162 135 ? ? ? A . n B 1 163 PRO 163 136 ? ? ? A . n B 1 164 SER 164 137 137 SER SER A . n B 1 165 THR 165 138 138 THR THR A . n B 1 166 ILE 166 139 139 ILE ILE A . n B 1 167 ALA 167 140 140 ALA ALA A . n B 1 168 VAL 168 141 141 VAL VAL A . n B 1 169 VAL 169 142 142 VAL VAL A . n B 1 170 GLY 170 143 143 GLY GLY A . n B 1 171 ALA 171 144 144 ALA ALA A . n B 1 172 THR 172 145 145 THR THR A . n B 1 173 GLY 173 146 146 GLY GLY A . n B 1 174 SER 174 147 147 SER SER A . n B 1 175 GLY 175 148 148 GLY GLY A . n B 1 176 VAL 176 149 149 VAL VAL A . n B 1 177 SER 177 150 150 SER SER A . n B 1 178 THR 178 151 151 THR THR A . n B 1 179 ALA 179 152 152 ALA ALA A . n B 1 180 VAL 180 153 153 VAL VAL A . n B 1 181 ALA 181 154 154 ALA ALA A . n B 1 182 ASN 182 155 155 ASN ASN A . n B 1 183 LEU 183 156 156 LEU LEU A . n B 1 184 LEU 184 157 157 LEU LEU A . n B 1 185 GLY 185 158 158 GLY GLY A . n B 1 186 LEU 186 159 159 LEU LEU A . n B 1 187 PHE 187 160 160 PHE PHE A . n B 1 188 TYR 188 161 161 TYR TYR A . n B 1 189 ILE 189 162 162 ILE ILE A . n B 1 190 PRO 190 163 163 PRO PRO A . n B 1 191 GLN 191 164 164 GLN GLN A . n B 1 192 VAL 192 165 165 VAL VAL A . n B 1 193 SER 193 166 166 SER SER A . n B 1 194 TYR 194 167 167 TYR TYR A . n B 1 195 ALA 195 168 168 ALA ALA A . n B 1 196 SER 196 169 169 SER SER A . n B 1 197 SER 197 170 170 SER SER A . n B 1 198 SER 198 171 171 SER SER A . n B 1 199 ARG 199 172 172 ARG ARG A . n B 1 200 LEU 200 173 173 LEU LEU A . n B 1 201 LEU 201 174 174 LEU LEU A . n B 1 202 SER 202 175 175 SER SER A . n B 1 203 ASN 203 176 176 ASN ASN A . n B 1 204 LYS 204 177 177 LYS LYS A . n B 1 205 ASN 205 178 178 ASN ASN A . n B 1 206 GLN 206 179 179 GLN GLN A . n B 1 207 PHE 207 180 180 PHE PHE A . n B 1 208 LYS 208 181 181 LYS LYS A . n B 1 209 SER 209 182 182 SER SER A . n B 1 210 PHE 210 183 183 PHE PHE A . n B 1 211 LEU 211 184 184 LEU LEU A . n B 1 212 ARG 212 185 185 ARG ARG A . n B 1 213 THR 213 186 186 THR THR A . n B 1 214 ILE 214 187 187 ILE ILE A . n B 1 215 PRO 215 188 188 PRO PRO A . n B 1 216 ASN 216 189 189 ASN ASN A . n B 1 217 ASP 217 190 190 ASP ASP A . n B 1 218 GLU 218 191 191 GLU GLU A . n B 1 219 HIS 219 192 192 HIS HIS A . n B 1 220 GLN 220 193 193 GLN GLN A . n B 1 221 ALA 221 194 194 ALA ALA A . n B 1 222 THR 222 195 195 THR THR A . n B 1 223 ALA 223 196 196 ALA ALA A . n B 1 224 MET 224 197 197 MET MET A . n B 1 225 ALA 225 198 198 ALA ALA A . n B 1 226 ASP 226 199 199 ASP ASP A . n B 1 227 ILE 227 200 200 ILE ILE A . n B 1 228 ILE 228 201 201 ILE ILE A . n B 1 229 GLU 229 202 202 GLU GLU A . n B 1 230 TYR 230 203 203 TYR TYR A . n B 1 231 PHE 231 204 204 PHE PHE A . n B 1 232 ARG 232 205 205 ARG ARG A . n B 1 233 TRP 233 206 206 TRP TRP A . n B 1 234 ASN 234 207 207 ASN ASN A . n B 1 235 TRP 235 208 208 TRP TRP A . n B 1 236 VAL 236 209 209 VAL VAL A . n B 1 237 GLY 237 210 210 GLY GLY A . n B 1 238 THR 238 211 211 THR THR A . n B 1 239 ILE 239 212 212 ILE ILE A . n B 1 240 ALA 240 213 213 ALA ALA A . n B 1 241 ALA 241 214 214 ALA ALA A . n B 1 242 ASP 242 215 215 ASP ASP A . n B 1 243 ASP 243 216 216 ASP ASP A . n B 1 244 ASP 244 217 217 ASP ASP A . n B 1 245 TYR 245 218 218 TYR TYR A . n B 1 246 GLY 246 219 219 GLY GLY A . n B 1 247 ARG 247 220 220 ARG ARG A . n B 1 248 PRO 248 221 221 PRO PRO A . n B 1 249 GLY 249 222 222 GLY GLY A . n B 1 250 ILE 250 223 223 ILE ILE A . n B 1 251 GLU 251 224 224 GLU GLU A . n B 1 252 LYS 252 225 225 LYS LYS A . n B 1 253 PHE 253 226 226 PHE PHE A . n B 1 254 ARG 254 227 227 ARG ARG A . n B 1 255 GLU 255 228 228 GLU GLU A . n B 1 256 GLU 256 229 229 GLU GLU A . n B 1 257 ALA 257 230 230 ALA ALA A . n B 1 258 GLU 258 231 231 GLU GLU A . n B 1 259 GLU 259 232 232 GLU GLU A . n B 1 260 ARG 260 233 233 ARG ARG A . n B 1 261 ASP 261 234 234 ASP ASP A . n B 1 262 ILE 262 235 235 ILE ILE A . n B 1 263 CSO 263 236 236 CSO CSO A . n B 1 264 ILE 264 237 237 ILE ILE A . n B 1 265 ASP 265 238 238 ASP ASP A . n B 1 266 PHE 266 239 239 PHE PHE A . n B 1 267 SER 267 240 240 SER SER A . n B 1 268 GLU 268 241 241 GLU GLU A . n B 1 269 LEU 269 242 242 LEU LEU A . n B 1 270 ILE 270 243 243 ILE ILE A . n B 1 271 SER 271 244 244 SER SER A . n B 1 272 GLN 272 245 245 GLN GLN A . n B 1 273 TYR 273 246 246 TYR TYR A . n B 1 274 SER 274 247 247 SER SER A . n B 1 275 ASP 275 248 248 ASP ASP A . n B 1 276 GLU 276 249 249 GLU GLU A . n B 1 277 GLU 277 250 250 GLU GLU A . n B 1 278 GLU 278 251 251 GLU GLU A . n B 1 279 ILE 279 252 252 ILE ILE A . n B 1 280 GLN 280 253 253 GLN GLN A . n B 1 281 HIS 281 254 254 HIS HIS A . n B 1 282 VAL 282 255 255 VAL VAL A . n B 1 283 VAL 283 256 256 VAL VAL A . n B 1 284 GLU 284 257 257 GLU GLU A . n B 1 285 VAL 285 258 258 VAL VAL A . n B 1 286 ILE 286 259 259 ILE ILE A . n B 1 287 GLN 287 260 260 GLN GLN A . n B 1 288 ASN 288 261 261 ASN ASN A . n B 1 289 SER 289 262 262 SER SER A . n B 1 290 THR 290 263 263 THR THR A . n B 1 291 ALA 291 264 264 ALA ALA A . n B 1 292 LYS 292 265 265 LYS LYS A . n B 1 293 VAL 293 266 266 VAL VAL A . n B 1 294 ILE 294 267 267 ILE ILE A . n B 1 295 VAL 295 268 268 VAL VAL A . n B 1 296 VAL 296 269 269 VAL VAL A . n B 1 297 PHE 297 270 270 PHE PHE A . n B 1 298 SER 298 271 271 SER SER A . n B 1 299 SER 299 272 272 SER SER A . n B 1 300 GLY 300 273 273 GLY GLY A . n B 1 301 PRO 301 274 274 PRO PRO A . n B 1 302 ASP 302 275 275 ASP ASP A . n B 1 303 LEU 303 276 276 LEU LEU A . n B 1 304 GLU 304 277 277 GLU GLU A . n B 1 305 PRO 305 278 278 PRO PRO A . n B 1 306 LEU 306 279 279 LEU LEU A . n B 1 307 ILE 307 280 280 ILE ILE A . n B 1 308 LYS 308 281 281 LYS LYS A . n B 1 309 GLU 309 282 282 GLU GLU A . n B 1 310 ILE 310 283 283 ILE ILE A . n B 1 311 VAL 311 284 284 VAL VAL A . n B 1 312 ARG 312 285 285 ARG ARG A . n B 1 313 ARG 313 286 286 ARG ARG A . n B 1 314 ASN 314 287 287 ASN ASN A . n B 1 315 ILE 315 288 288 ILE ILE A . n B 1 316 THR 316 289 289 THR THR A . n B 1 317 GLY 317 290 290 GLY GLY A . n B 1 318 LYS 318 291 291 LYS LYS A . n B 1 319 ILE 319 292 292 ILE ILE A . n B 1 320 TRP 320 293 293 TRP TRP A . n B 1 321 LEU 321 294 294 LEU LEU A . n B 1 322 ALA 322 295 295 ALA ALA A . n B 1 323 SER 323 296 296 SER SER A . n B 1 324 GLU 324 297 297 GLU GLU A . n B 1 325 ALA 325 298 298 ALA ALA A . n B 1 326 TRP 326 299 299 TRP TRP A . n B 1 327 ALA 327 300 300 ALA ALA A . n B 1 328 SER 328 301 301 SER SER A . n B 1 329 SER 329 302 302 SER SER A . n B 1 330 SER 330 303 303 SER SER A . n B 1 331 LEU 331 304 304 LEU LEU A . n B 1 332 ILE 332 305 305 ILE ILE A . n B 1 333 ALA 333 306 306 ALA ALA A . n B 1 334 MET 334 307 307 MET MET A . n B 1 335 PRO 335 308 308 PRO PRO A . n B 1 336 GLN 336 309 309 GLN GLN A . n B 1 337 TYR 337 310 310 TYR TYR A . n B 1 338 PHE 338 311 311 PHE PHE A . n B 1 339 HIS 339 312 312 HIS HIS A . n B 1 340 VAL 340 313 313 VAL VAL A . n B 1 341 VAL 341 314 314 VAL VAL A . n B 1 342 GLY 342 315 315 GLY GLY A . n B 1 343 GLY 343 316 316 GLY GLY A . n B 1 344 THR 344 317 317 THR THR A . n B 1 345 ILE 345 318 318 ILE ILE A . n B 1 346 GLY 346 319 319 GLY GLY A . n B 1 347 PHE 347 320 320 PHE PHE A . n B 1 348 ALA 348 321 321 ALA ALA A . n B 1 349 LEU 349 322 322 LEU LEU A . n B 1 350 LYS 350 323 323 LYS LYS A . n B 1 351 ALA 351 324 324 ALA ALA A . n B 1 352 GLY 352 325 325 GLY GLY A . n B 1 353 GLN 353 326 326 GLN GLN A . n B 1 354 ILE 354 327 327 ILE ILE A . n B 1 355 PRO 355 328 328 PRO PRO A . n B 1 356 GLY 356 329 329 GLY GLY A . n B 1 357 PHE 357 330 330 PHE PHE A . n B 1 358 ARG 358 331 331 ARG ARG A . n B 1 359 GLU 359 332 332 GLU GLU A . n B 1 360 PHE 360 333 333 PHE PHE A . n B 1 361 LEU 361 334 334 LEU LEU A . n B 1 362 LYS 362 335 335 LYS LYS A . n B 1 363 LYS 363 336 336 LYS LYS A . n B 1 364 VAL 364 337 337 VAL VAL A . n B 1 365 HIS 365 338 338 HIS HIS A . n B 1 366 PRO 366 339 339 PRO PRO A . n B 1 367 ARG 367 340 340 ARG ARG A . n B 1 368 LYS 368 341 341 LYS LYS A . n B 1 369 SER 369 342 342 SER SER A . n B 1 370 VAL 370 343 343 VAL VAL A . n B 1 371 HIS 371 344 344 HIS HIS A . n B 1 372 ASN 372 345 345 ASN ASN A . n B 1 373 GLY 373 346 346 GLY GLY A . n B 1 374 PHE 374 347 347 PHE PHE A . n B 1 375 ALA 375 348 348 ALA ALA A . n B 1 376 LYS 376 349 349 LYS LYS A . n B 1 377 GLU 377 350 350 GLU GLU A . n B 1 378 PHE 378 351 351 PHE PHE A . n B 1 379 TRP 379 352 352 TRP TRP A . n B 1 380 GLU 380 353 353 GLU GLU A . n B 1 381 GLU 381 354 354 GLU GLU A . n B 1 382 THR 382 355 355 THR THR A . n B 1 383 PHE 383 356 356 PHE PHE A . n B 1 384 ASN 384 357 357 ASN ASN A . n B 1 385 CYS 385 358 358 CYS CYS A . n B 1 386 HIS 386 359 359 HIS HIS A . n B 1 387 LEU 387 360 360 LEU LEU A . n B 1 388 GLN 388 361 361 GLN GLN A . n B 1 389 GLU 389 362 ? ? ? A . n B 1 390 GLY 390 363 ? ? ? A . n B 1 391 ALA 391 364 ? ? ? A . n B 1 392 LYS 392 365 ? ? ? A . n B 1 393 GLY 393 366 ? ? ? A . n B 1 394 PRO 394 367 ? ? ? A . n B 1 395 LEU 395 368 ? ? ? A . n B 1 396 PRO 396 369 ? ? ? A . n B 1 397 VAL 397 370 ? ? ? A . n B 1 398 ASP 398 371 ? ? ? A . n B 1 399 THR 399 372 ? ? ? A . n B 1 400 PHE 400 373 ? ? ? A . n B 1 401 LEU 401 374 ? ? ? A . n B 1 402 ARG 402 375 ? ? ? A . n B 1 403 GLY 403 376 ? ? ? A . n B 1 404 HIS 404 377 ? ? ? A . n B 1 405 GLU 405 378 ? ? ? A . n B 1 406 GLU 406 379 ? ? ? A . n B 1 407 SER 407 380 ? ? ? A . n B 1 408 GLY 408 381 ? ? ? A . n B 1 409 ASP 409 382 ? ? ? A . n B 1 410 ARG 410 383 ? ? ? A . n B 1 411 PHE 411 384 ? ? ? A . n B 1 412 SER 412 385 ? ? ? A . n B 1 413 ASN 413 386 ? ? ? A . n B 1 414 SER 414 387 ? ? ? A . n B 1 415 SER 415 388 ? ? ? A . n B 1 416 THR 416 389 ? ? ? A . n B 1 417 ALA 417 390 ? ? ? A . n B 1 418 PHE 418 391 ? ? ? A . n B 1 419 ARG 419 392 392 ARG ARG A . n B 1 420 PRO 420 393 393 PRO PRO A . n B 1 421 LEU 421 394 394 LEU LEU A . n B 1 422 CYS 422 395 395 CYS CYS A . n B 1 423 THR 423 396 396 THR THR A . n B 1 424 GLY 424 397 397 GLY GLY A . n B 1 425 ASP 425 398 398 ASP ASP A . n B 1 426 GLU 426 399 399 GLU GLU A . n B 1 427 ASN 427 400 400 ASN ASN A . n B 1 428 ILE 428 401 401 ILE ILE A . n B 1 429 SER 429 402 402 SER SER A . n B 1 430 SER 430 403 403 SER SER A . n B 1 431 VAL 431 404 404 VAL VAL A . n B 1 432 GLU 432 405 405 GLU GLU A . n B 1 433 THR 433 406 406 THR THR A . n B 1 434 PRO 434 407 407 PRO PRO A . n B 1 435 TYR 435 408 408 TYR TYR A . n B 1 436 ILE 436 409 409 ILE ILE A . n B 1 437 ASP 437 410 410 ASP ASP A . n B 1 438 TYR 438 411 411 TYR TYR A . n B 1 439 THR 439 412 412 THR THR A . n B 1 440 HIS 440 413 413 HIS HIS A . n B 1 441 LEU 441 414 414 LEU LEU A . n B 1 442 ARG 442 415 415 ARG ARG A . n B 1 443 ILE 443 416 416 ILE ILE A . n B 1 444 SER 444 417 417 SER SER A . n B 1 445 TYR 445 418 418 TYR TYR A . n B 1 446 ASN 446 419 419 ASN ASN A . n B 1 447 VAL 447 420 420 VAL VAL A . n B 1 448 TYR 448 421 421 TYR TYR A . n B 1 449 LEU 449 422 422 LEU LEU A . n B 1 450 ALA 450 423 423 ALA ALA A . n B 1 451 VAL 451 424 424 VAL VAL A . n B 1 452 TYR 452 425 425 TYR TYR A . n B 1 453 SER 453 426 426 SER SER A . n B 1 454 ILE 454 427 427 ILE ILE A . n B 1 455 ALA 455 428 428 ALA ALA A . n B 1 456 HIS 456 429 429 HIS HIS A . n B 1 457 ALA 457 430 430 ALA ALA A . n B 1 458 LEU 458 431 431 LEU LEU A . n B 1 459 GLN 459 432 432 GLN GLN A . n B 1 460 ASP 460 433 433 ASP ASP A . n B 1 461 ILE 461 434 434 ILE ILE A . n B 1 462 TYR 462 435 435 TYR TYR A . n B 1 463 THR 463 436 436 THR THR A . n B 1 464 CYS 464 437 437 CYS CYS A . n B 1 465 LEU 465 438 438 LEU LEU A . n B 1 466 PRO 466 439 439 PRO PRO A . n B 1 467 GLY 467 440 440 GLY GLY A . n B 1 468 ARG 468 441 441 ARG ARG A . n B 1 469 GLY 469 442 442 GLY GLY A . n B 1 470 LEU 470 443 443 LEU LEU A . n B 1 471 PHE 471 444 444 PHE PHE A . n B 1 472 THR 472 445 445 THR THR A . n B 1 473 ASN 473 446 446 ASN ASN A . n B 1 474 GLY 474 447 447 GLY GLY A . n B 1 475 SER 475 448 448 SER SER A . n B 1 476 CYS 476 449 449 CYS CYS A . n B 1 477 ALA 477 450 450 ALA ALA A . n B 1 478 ASP 478 451 451 ASP ASP A . n B 1 479 ILE 479 452 452 ILE ILE A . n B 1 480 LYS 480 453 453 LYS LYS A . n B 1 481 LYS 481 454 454 LYS LYS A . n B 1 482 VAL 482 455 455 VAL VAL A . n B 1 483 GLU 483 456 456 GLU GLU A . n B 1 484 ALA 484 457 457 ALA ALA A . n B 1 485 TRP 485 458 458 TRP TRP A . n B 1 486 GLN 486 459 459 GLN GLN A . n B 1 487 VAL 487 460 460 VAL VAL A . n B 1 488 LEU 488 461 461 LEU LEU A . n B 1 489 LYS 489 462 462 LYS LYS A . n B 1 490 HIS 490 463 463 HIS HIS A . n B 1 491 LEU 491 464 464 LEU LEU A . n B 1 492 ARG 492 465 465 ARG ARG A . n B 1 493 HIS 493 466 466 HIS HIS A . n B 1 494 LEU 494 467 467 LEU LEU A . n B 1 495 ASN 495 468 468 ASN ASN A . n B 1 496 PHE 496 469 469 PHE PHE A . n B 1 497 THR 497 470 470 THR THR A . n B 1 498 ASN 498 471 471 ASN ASN A . n B 1 499 ASN 499 472 472 ASN ASN A . n B 1 500 MET 500 473 473 MET MET A . n B 1 501 GLY 501 474 474 GLY GLY A . n B 1 502 GLU 502 475 475 GLU GLU A . n B 1 503 GLN 503 476 476 GLN GLN A . n B 1 504 VAL 504 477 477 VAL VAL A . n B 1 505 THR 505 478 478 THR THR A . n B 1 506 PHE 506 479 479 PHE PHE A . n B 1 507 ASP 507 480 480 ASP ASP A . n B 1 508 GLU 508 481 481 GLU GLU A . n B 1 509 CSO 509 482 482 CSO CSO A . n B 1 510 GLY 510 483 483 GLY GLY A . n B 1 511 ASP 511 484 484 ASP ASP A . n B 1 512 LEU 512 485 485 LEU LEU A . n B 1 513 VAL 513 486 486 VAL VAL A . n B 1 514 GLY 514 487 487 GLY GLY A . n B 1 515 ASN 515 488 488 ASN ASN A . n B 1 516 TYR 516 489 489 TYR TYR A . n B 1 517 SER 517 490 490 SER SER A . n B 1 518 ILE 518 491 491 ILE ILE A . n B 1 519 ILE 519 492 492 ILE ILE A . n B 1 520 ASN 520 493 493 ASN ASN A . n B 1 521 TRP 521 494 494 TRP TRP A . n B 1 522 HIS 522 495 495 HIS HIS A . n B 1 523 LEU 523 496 496 LEU LEU A . n B 1 524 SER 524 497 497 SER SER A . n B 1 525 PRO 525 498 498 PRO PRO A . n B 1 526 GLU 526 499 499 GLU GLU A . n B 1 527 ASP 527 500 500 ASP ASP A . n B 1 528 GLY 528 501 501 GLY GLY A . n B 1 529 SER 529 502 502 SER SER A . n B 1 530 ILE 530 503 503 ILE ILE A . n B 1 531 VAL 531 504 504 VAL VAL A . n B 1 532 PHE 532 505 505 PHE PHE A . n B 1 533 LYS 533 506 506 LYS LYS A . n B 1 534 GLU 534 507 507 GLU GLU A . n B 1 535 VAL 535 508 508 VAL VAL A . n B 1 536 GLY 536 509 509 GLY GLY A . n B 1 537 TYR 537 510 510 TYR TYR A . n B 1 538 TYR 538 511 511 TYR TYR A . n B 1 539 ASN 539 512 512 ASN ASN A . n B 1 540 VAL 540 513 513 VAL VAL A . n B 1 541 TYR 541 514 514 TYR TYR A . n B 1 542 ALA 542 515 515 ALA ALA A . n B 1 543 LYS 543 516 516 LYS LYS A . n B 1 544 LYS 544 517 517 LYS LYS A . n B 1 545 GLY 545 518 518 GLY GLY A . n B 1 546 GLU 546 519 519 GLU GLU A . n B 1 547 ARG 547 520 520 ARG ARG A . n B 1 548 LEU 548 521 521 LEU LEU A . n B 1 549 PHE 549 522 522 PHE PHE A . n B 1 550 ILE 550 523 523 ILE ILE A . n B 1 551 ASN 551 524 524 ASN ASN A . n B 1 552 GLU 552 525 525 GLU GLU A . n B 1 553 GLU 553 526 526 GLU GLU A . n B 1 554 LYS 554 527 527 LYS LYS A . n B 1 555 ILE 555 528 528 ILE ILE A . n B 1 556 LEU 556 529 529 LEU LEU A . n B 1 557 TRP 557 530 530 TRP TRP A . n B 1 558 SER 558 531 531 SER SER A . n B 1 559 GLY 559 532 532 GLY GLY A . n B 1 560 PHE 560 533 533 PHE PHE A . n B 1 561 SER 561 534 534 SER SER A . n B 1 562 ARG 562 535 535 ARG ARG A . n B 1 563 GLU 563 536 536 GLU GLU A . n B 1 564 VAL 564 537 537 VAL VAL A . n B 1 565 PRO 565 538 538 PRO PRO A . n B 1 566 PHE 566 539 ? ? ? A . n B 1 567 SER 567 540 ? ? ? A . n B 1 568 ASN 568 541 ? ? ? A . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code C 2 GD3 1 601 601 GD3 GD3 B . D 3 MG 1 602 602 MG MG B . E 3 MG 1 603 603 MG MG B . F 4 BCT 1 604 604 BCT BCT B . G 5 CL 1 605 605 CL CL B . H 6 NAG 1 606 606 NAG NAG B . I 6 NAG 1 607 607 NAG NAG B . J 6 NAG 1 608 608 NAG NAG B . K 7 TCR 1 609 609 TCR TCR B . L 2 GD3 1 601 601 GD3 GD3 A . M 3 MG 1 602 602 MG MG A . N 4 BCT 1 603 603 BCT BCT A . O 5 CL 1 604 604 CL CL A . P 6 NAG 1 605 605 NAG NAG A . Q 6 NAG 1 606 606 NAG NAG A . R 6 NAG 1 607 607 NAG NAG A . S 6 NAG 1 608 608 NAG NAG A . T 7 TCR 1 609 609 TCR TCR A . U 8 HOH 1 701 701 HOH HOH B . U 8 HOH 2 702 702 HOH HOH B . U 8 HOH 3 703 703 HOH HOH B . U 8 HOH 4 704 704 HOH HOH B . U 8 HOH 5 705 705 HOH HOH B . U 8 HOH 6 706 706 HOH HOH B . U 8 HOH 7 707 707 HOH HOH B . U 8 HOH 8 708 708 HOH HOH B . U 8 HOH 9 709 709 HOH HOH B . U 8 HOH 10 710 710 HOH HOH B . U 8 HOH 11 711 711 HOH HOH B . V 8 HOH 1 701 701 HOH HOH A . V 8 HOH 2 702 702 HOH HOH A . V 8 HOH 3 703 703 HOH HOH A . V 8 HOH 4 704 704 HOH HOH A . V 8 HOH 5 705 705 HOH HOH A . V 8 HOH 6 706 706 HOH HOH A . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A CSO 263 B CSO 236 ? CYS 'modified residue' 2 A CSO 509 B CSO 482 ? CYS 'modified residue' 3 B CSO 263 A CSO 236 ? CYS 'modified residue' 4 B CSO 509 A CSO 482 ? CYS 'modified residue' # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_and_software_defined_assembly _pdbx_struct_assembly.method_details PISA _pdbx_struct_assembly.oligomeric_details dimeric _pdbx_struct_assembly.oligomeric_count 2 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 1 'ABSA (A^2)' 7350 ? 1 MORE -51 ? 1 'SSA (A^2)' 38240 ? # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # loop_ _pdbx_struct_conn_angle.id _pdbx_struct_conn_angle.ptnr1_label_atom_id _pdbx_struct_conn_angle.ptnr1_label_alt_id _pdbx_struct_conn_angle.ptnr1_label_asym_id _pdbx_struct_conn_angle.ptnr1_label_comp_id _pdbx_struct_conn_angle.ptnr1_label_seq_id _pdbx_struct_conn_angle.ptnr1_auth_atom_id _pdbx_struct_conn_angle.ptnr1_auth_asym_id _pdbx_struct_conn_angle.ptnr1_auth_comp_id _pdbx_struct_conn_angle.ptnr1_auth_seq_id _pdbx_struct_conn_angle.ptnr1_PDB_ins_code _pdbx_struct_conn_angle.ptnr1_symmetry _pdbx_struct_conn_angle.ptnr2_label_atom_id _pdbx_struct_conn_angle.ptnr2_label_alt_id _pdbx_struct_conn_angle.ptnr2_label_asym_id _pdbx_struct_conn_angle.ptnr2_label_comp_id _pdbx_struct_conn_angle.ptnr2_label_seq_id _pdbx_struct_conn_angle.ptnr2_auth_atom_id _pdbx_struct_conn_angle.ptnr2_auth_asym_id _pdbx_struct_conn_angle.ptnr2_auth_comp_id _pdbx_struct_conn_angle.ptnr2_auth_seq_id _pdbx_struct_conn_angle.ptnr2_PDB_ins_code _pdbx_struct_conn_angle.ptnr2_symmetry _pdbx_struct_conn_angle.ptnr3_label_atom_id _pdbx_struct_conn_angle.ptnr3_label_alt_id _pdbx_struct_conn_angle.ptnr3_label_asym_id _pdbx_struct_conn_angle.ptnr3_label_comp_id _pdbx_struct_conn_angle.ptnr3_label_seq_id _pdbx_struct_conn_angle.ptnr3_auth_atom_id _pdbx_struct_conn_angle.ptnr3_auth_asym_id _pdbx_struct_conn_angle.ptnr3_auth_comp_id _pdbx_struct_conn_angle.ptnr3_auth_seq_id _pdbx_struct_conn_angle.ptnr3_PDB_ins_code _pdbx_struct_conn_angle.ptnr3_symmetry _pdbx_struct_conn_angle.value _pdbx_struct_conn_angle.value_esd 1 O ? A ILE 108 ? B ILE 81 ? 1_555 MG ? E MG . ? B MG 603 ? 1_555 O ? A LEU 114 ? B LEU 87 ? 1_555 84.9 ? 2 O ? A ILE 108 ? B ILE 81 ? 1_555 MG ? E MG . ? B MG 603 ? 1_555 O ? A LEU 115 ? B LEU 88 ? 1_555 145.0 ? 3 O ? A LEU 114 ? B LEU 87 ? 1_555 MG ? E MG . ? B MG 603 ? 1_555 O ? A LEU 115 ? B LEU 88 ? 1_555 61.5 ? 4 OE1 ? A GLU 256 ? B GLU 229 ? 1_555 GD ? C GD3 . ? B GD3 601 ? 1_555 OE2 ? A GLU 256 ? B GLU 229 ? 1_555 48.2 ? 5 OE1 ? A GLU 256 ? B GLU 229 ? 1_555 GD ? C GD3 . ? B GD3 601 ? 1_555 OE1 ? A GLU 259 ? B GLU 232 ? 1_555 79.7 ? 6 OE2 ? A GLU 256 ? B GLU 229 ? 1_555 GD ? C GD3 . ? B GD3 601 ? 1_555 OE1 ? A GLU 259 ? B GLU 232 ? 1_555 94.6 ? 7 O ? A SER 267 ? B SER 240 ? 1_555 MG ? D MG . ? B MG 602 ? 1_555 OG ? A SER 267 ? B SER 240 ? 1_555 62.4 ? 8 O ? A SER 267 ? B SER 240 ? 1_555 MG ? D MG . ? B MG 602 ? 1_555 O ? U HOH . ? B HOH 706 ? 1_555 69.2 ? 9 OG ? A SER 267 ? B SER 240 ? 1_555 MG ? D MG . ? B MG 602 ? 1_555 O ? U HOH . ? B HOH 706 ? 1_555 78.2 ? 10 O ? B ILE 108 ? A ILE 81 ? 1_555 MG ? M MG . ? A MG 602 ? 1_555 O ? B SER 111 ? A SER 84 ? 1_555 77.5 ? 11 O ? B ILE 108 ? A ILE 81 ? 1_555 MG ? M MG . ? A MG 602 ? 1_555 O ? B LEU 114 ? A LEU 87 ? 1_555 90.9 ? 12 O ? B SER 111 ? A SER 84 ? 1_555 MG ? M MG . ? A MG 602 ? 1_555 O ? B LEU 114 ? A LEU 87 ? 1_555 80.5 ? 13 O ? B ILE 108 ? A ILE 81 ? 1_555 MG ? M MG . ? A MG 602 ? 1_555 O ? B LEU 115 ? A LEU 88 ? 1_555 147.7 ? 14 O ? B SER 111 ? A SER 84 ? 1_555 MG ? M MG . ? A MG 602 ? 1_555 O ? B LEU 115 ? A LEU 88 ? 1_555 116.1 ? 15 O ? B LEU 114 ? A LEU 87 ? 1_555 MG ? M MG . ? A MG 602 ? 1_555 O ? B LEU 115 ? A LEU 88 ? 1_555 64.9 ? 16 OE1 ? B GLU 256 ? A GLU 229 ? 1_555 GD ? L GD3 . ? A GD3 601 ? 1_555 OE2 ? B GLU 256 ? A GLU 229 ? 1_555 47.5 ? 17 OE1 ? B GLU 256 ? A GLU 229 ? 1_555 GD ? L GD3 . ? A GD3 601 ? 1_555 OE1 ? B GLU 259 ? A GLU 232 ? 1_555 80.2 ? 18 OE2 ? B GLU 256 ? A GLU 229 ? 1_555 GD ? L GD3 . ? A GD3 601 ? 1_555 OE1 ? B GLU 259 ? A GLU 232 ? 1_555 89.3 ? # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2016-06-22 2 'Structure model' 1 1 2016-07-20 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # _pdbx_audit_revision_group.ordinal 1 _pdbx_audit_revision_group.revision_ordinal 2 _pdbx_audit_revision_group.data_content_type 'Structure model' _pdbx_audit_revision_group.group 'Database references' # loop_ _software.citation_id _software.classification _software.compiler_name _software.compiler_version _software.contact_author _software.contact_author_email _software.date _software.description _software.dependencies _software.hardware _software.language _software.location _software.mods _software.name _software.os _software.os_version _software.type _software.version _software.pdbx_ordinal ? refinement ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0049 1 ? 'data scaling' ? ? ? ? ? ? ? ? ? ? ? SCALEPACK ? ? ? . 2 ? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? 3.15 3 ? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? . 4 ? phasing ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? . 5 # _pdbx_validate_rmsd_angle.id 1 _pdbx_validate_rmsd_angle.PDB_model_num 1 _pdbx_validate_rmsd_angle.auth_atom_id_1 C _pdbx_validate_rmsd_angle.auth_asym_id_1 A _pdbx_validate_rmsd_angle.auth_comp_id_1 VAL _pdbx_validate_rmsd_angle.auth_seq_id_1 537 _pdbx_validate_rmsd_angle.PDB_ins_code_1 ? _pdbx_validate_rmsd_angle.label_alt_id_1 ? _pdbx_validate_rmsd_angle.auth_atom_id_2 N _pdbx_validate_rmsd_angle.auth_asym_id_2 A _pdbx_validate_rmsd_angle.auth_comp_id_2 PRO _pdbx_validate_rmsd_angle.auth_seq_id_2 538 _pdbx_validate_rmsd_angle.PDB_ins_code_2 ? _pdbx_validate_rmsd_angle.label_alt_id_2 ? _pdbx_validate_rmsd_angle.auth_atom_id_3 CA _pdbx_validate_rmsd_angle.auth_asym_id_3 A _pdbx_validate_rmsd_angle.auth_comp_id_3 PRO _pdbx_validate_rmsd_angle.auth_seq_id_3 538 _pdbx_validate_rmsd_angle.PDB_ins_code_3 ? _pdbx_validate_rmsd_angle.label_alt_id_3 ? _pdbx_validate_rmsd_angle.angle_value 151.00 _pdbx_validate_rmsd_angle.angle_target_value 119.30 _pdbx_validate_rmsd_angle.angle_deviation 31.70 _pdbx_validate_rmsd_angle.angle_standard_deviation 1.50 _pdbx_validate_rmsd_angle.linker_flag Y # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 ALA B 46 ? ? -91.76 55.30 2 1 ARG B 62 ? ? 70.44 96.85 3 1 LEU B 88 ? ? 45.33 76.86 4 1 GLN B 117 ? ? -68.74 -75.55 5 1 ASN B 118 ? ? -21.15 -43.90 6 1 THR B 145 ? ? -92.66 -63.70 7 1 ALA B 168 ? ? -141.63 -8.47 8 1 ASN B 207 ? ? -146.95 17.68 9 1 ARG B 340 ? ? -93.09 -66.79 10 1 LYS B 349 ? ? -56.27 -72.65 11 1 ARG B 415 ? ? -118.13 -78.74 12 1 ARG B 441 ? ? -100.20 43.03 13 1 ASN B 472 ? ? -37.89 -34.90 14 1 LYS B 517 ? ? -38.49 119.50 15 1 ALA A 46 ? ? -86.56 41.56 16 1 ARG A 62 ? ? 65.90 109.90 17 1 LEU A 88 ? ? 50.47 80.22 18 1 ALA A 144 ? ? -81.84 -159.37 19 1 ALA A 168 ? ? -149.11 -6.11 20 1 ASN A 207 ? ? -137.28 -38.99 21 1 ASP A 215 ? ? -68.97 72.90 22 1 ASP A 216 ? ? -162.79 -165.95 23 1 ASN A 261 ? ? -67.34 7.15 24 1 ARG A 340 ? ? -72.71 -77.22 25 1 ARG A 415 ? ? -115.20 -76.90 26 1 PHE A 444 ? ? -91.18 -154.91 27 1 PHE A 533 ? ? -132.25 -36.05 # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 Y 1 B LYS 29 ? CG ? A LYS 56 CG 2 1 Y 1 B LYS 29 ? CD ? A LYS 56 CD 3 1 Y 1 B LYS 29 ? CE ? A LYS 56 CE 4 1 Y 1 B LYS 29 ? NZ ? A LYS 56 NZ 5 1 Y 1 B LYS 47 ? CG ? A LYS 74 CG 6 1 Y 1 B LYS 47 ? CD ? A LYS 74 CD 7 1 Y 1 B LYS 47 ? CE ? A LYS 74 CE 8 1 Y 1 B LYS 47 ? NZ ? A LYS 74 NZ 9 1 Y 1 B ASP 48 ? CG ? A ASP 75 CG 10 1 Y 1 B ASP 48 ? OD1 ? A ASP 75 OD1 11 1 Y 1 B ASP 48 ? OD2 ? A ASP 75 OD2 12 1 Y 1 B GLU 56 ? CG ? A GLU 83 CG 13 1 Y 1 B GLU 56 ? CD ? A GLU 83 CD 14 1 Y 1 B GLU 56 ? OE1 ? A GLU 83 OE1 15 1 Y 1 B GLU 56 ? OE2 ? A GLU 83 OE2 16 1 Y 1 B VAL 58 ? CG1 ? A VAL 85 CG1 17 1 Y 1 B VAL 58 ? CG2 ? A VAL 85 CG2 18 1 Y 1 B GLU 59 ? CG ? A GLU 86 CG 19 1 Y 1 B GLU 59 ? CD ? A GLU 86 CD 20 1 Y 1 B GLU 59 ? OE1 ? A GLU 86 OE1 21 1 Y 1 B GLU 59 ? OE2 ? A GLU 86 OE2 22 1 Y 1 B ASN 90 ? CG ? A ASN 117 CG 23 1 Y 1 B ASN 90 ? OD1 ? A ASN 117 OD1 24 1 Y 1 B ASN 90 ? ND2 ? A ASN 117 ND2 25 1 Y 1 B ILE 120 ? CG1 ? A ILE 147 CG1 26 1 Y 1 B ILE 120 ? CG2 ? A ILE 147 CG2 27 1 Y 1 B ILE 120 ? CD1 ? A ILE 147 CD1 28 1 Y 1 B GLU 231 ? CG ? A GLU 258 CG 29 1 Y 1 B GLU 231 ? CD ? A GLU 258 CD 30 1 Y 1 B GLU 231 ? OE1 ? A GLU 258 OE1 31 1 Y 1 B GLU 231 ? OE2 ? A GLU 258 OE2 32 1 Y 1 B GLU 249 ? CG ? A GLU 276 CG 33 1 Y 1 B GLU 249 ? CD ? A GLU 276 CD 34 1 Y 1 B GLU 249 ? OE1 ? A GLU 276 OE1 35 1 Y 1 B GLU 249 ? OE2 ? A GLU 276 OE2 36 1 Y 1 B GLU 250 ? CG ? A GLU 277 CG 37 1 Y 1 B GLU 250 ? CD ? A GLU 277 CD 38 1 Y 1 B GLU 250 ? OE1 ? A GLU 277 OE1 39 1 Y 1 B GLU 250 ? OE2 ? A GLU 277 OE2 40 1 Y 1 B GLN 253 ? CG ? A GLN 280 CG 41 1 Y 1 B GLN 253 ? CD ? A GLN 280 CD 42 1 Y 1 B GLN 253 ? OE1 ? A GLN 280 OE1 43 1 Y 1 B GLN 253 ? NE2 ? A GLN 280 NE2 44 1 Y 1 B GLU 332 ? CG ? A GLU 359 CG 45 1 Y 1 B GLU 332 ? CD ? A GLU 359 CD 46 1 Y 1 B GLU 332 ? OE1 ? A GLU 359 OE1 47 1 Y 1 B GLU 332 ? OE2 ? A GLU 359 OE2 48 1 Y 1 B ARG 340 ? CG ? A ARG 367 CG 49 1 Y 1 B ARG 340 ? CD ? A ARG 367 CD 50 1 Y 1 B ARG 340 ? NE ? A ARG 367 NE 51 1 Y 1 B ARG 340 ? CZ ? A ARG 367 CZ 52 1 Y 1 B ARG 340 ? NH1 ? A ARG 367 NH1 53 1 Y 1 B ARG 340 ? NH2 ? A ARG 367 NH2 54 1 Y 1 B LYS 341 ? CG ? A LYS 368 CG 55 1 Y 1 B LYS 341 ? CD ? A LYS 368 CD 56 1 Y 1 B LYS 341 ? CE ? A LYS 368 CE 57 1 Y 1 B LYS 341 ? NZ ? A LYS 368 NZ 58 1 Y 1 B VAL 343 ? CG1 ? A VAL 370 CG1 59 1 Y 1 B VAL 343 ? CG2 ? A VAL 370 CG2 60 1 Y 1 B LYS 349 ? CG ? A LYS 376 CG 61 1 Y 1 B LYS 349 ? CD ? A LYS 376 CD 62 1 Y 1 B LYS 349 ? CE ? A LYS 376 CE 63 1 Y 1 B LYS 349 ? NZ ? A LYS 376 NZ 64 1 Y 1 B GLN 361 ? CG ? A GLN 388 CG 65 1 Y 1 B GLN 361 ? CD ? A GLN 388 CD 66 1 Y 1 B GLN 361 ? OE1 ? A GLN 388 OE1 67 1 Y 1 B GLN 361 ? NE2 ? A GLN 388 NE2 68 1 Y 1 B LEU 394 ? CG ? A LEU 421 CG 69 1 Y 1 B LEU 394 ? CD1 ? A LEU 421 CD1 70 1 Y 1 B LEU 394 ? CD2 ? A LEU 421 CD2 71 1 Y 1 B SER 402 ? OG ? A SER 429 OG 72 1 Y 1 B GLU 405 ? CG ? A GLU 432 CG 73 1 Y 1 B GLU 405 ? CD ? A GLU 432 CD 74 1 Y 1 B GLU 405 ? OE1 ? A GLU 432 OE1 75 1 Y 1 B GLU 405 ? OE2 ? A GLU 432 OE2 76 1 Y 1 B ARG 441 ? CG ? A ARG 468 CG 77 1 Y 1 B ARG 441 ? CD ? A ARG 468 CD 78 1 Y 1 B ARG 441 ? NE ? A ARG 468 NE 79 1 Y 1 B ARG 441 ? CZ ? A ARG 468 CZ 80 1 Y 1 B ARG 441 ? NH1 ? A ARG 468 NH1 81 1 Y 1 B ARG 441 ? NH2 ? A ARG 468 NH2 82 1 Y 1 B LYS 454 ? CG ? A LYS 481 CG 83 1 Y 1 B LYS 454 ? CD ? A LYS 481 CD 84 1 Y 1 B LYS 454 ? CE ? A LYS 481 CE 85 1 Y 1 B LYS 454 ? NZ ? A LYS 481 NZ 86 1 Y 1 B GLU 481 ? CG ? A GLU 508 CG 87 1 Y 1 B GLU 481 ? CD ? A GLU 508 CD 88 1 Y 1 B GLU 481 ? OE1 ? A GLU 508 OE1 89 1 Y 1 B GLU 481 ? OE2 ? A GLU 508 OE2 90 1 Y 1 B GLU 499 ? CG ? A GLU 526 CG 91 1 Y 1 B GLU 499 ? CD ? A GLU 526 CD 92 1 Y 1 B GLU 499 ? OE1 ? A GLU 526 OE1 93 1 Y 1 B GLU 499 ? OE2 ? A GLU 526 OE2 94 1 Y 1 B LYS 516 ? CG ? A LYS 543 CG 95 1 Y 1 B LYS 516 ? CD ? A LYS 543 CD 96 1 Y 1 B LYS 516 ? CE ? A LYS 543 CE 97 1 Y 1 B LYS 516 ? NZ ? A LYS 543 NZ 98 1 Y 1 B LYS 517 ? CG ? A LYS 544 CG 99 1 Y 1 B LYS 517 ? CD ? A LYS 544 CD 100 1 Y 1 B LYS 517 ? CE ? A LYS 544 CE 101 1 Y 1 B LYS 517 ? NZ ? A LYS 544 NZ 102 1 Y 1 B GLU 519 ? CG ? A GLU 546 CG 103 1 Y 1 B GLU 519 ? CD ? A GLU 546 CD 104 1 Y 1 B GLU 519 ? OE1 ? A GLU 546 OE1 105 1 Y 1 B GLU 519 ? OE2 ? A GLU 546 OE2 106 1 Y 1 B LEU 529 ? CG ? A LEU 556 CG 107 1 Y 1 B LEU 529 ? CD1 ? A LEU 556 CD1 108 1 Y 1 B LEU 529 ? CD2 ? A LEU 556 CD2 109 1 Y 1 B PHE 533 ? CG ? A PHE 560 CG 110 1 Y 1 B PHE 533 ? CD1 ? A PHE 560 CD1 111 1 Y 1 B PHE 533 ? CD2 ? A PHE 560 CD2 112 1 Y 1 B PHE 533 ? CE1 ? A PHE 560 CE1 113 1 Y 1 B PHE 533 ? CE2 ? A PHE 560 CE2 114 1 Y 1 B PHE 533 ? CZ ? A PHE 560 CZ 115 1 Y 1 B SER 534 ? OG ? A SER 561 OG 116 1 Y 1 A PRO 22 ? CG ? B PRO 49 CG 117 1 Y 1 A PRO 22 ? CD ? B PRO 49 CD 118 1 Y 1 A LYS 28 ? CG ? B LYS 55 CG 119 1 Y 1 A LYS 28 ? CD ? B LYS 55 CD 120 1 Y 1 A LYS 28 ? CE ? B LYS 55 CE 121 1 Y 1 A LYS 28 ? NZ ? B LYS 55 NZ 122 1 Y 1 A LYS 29 ? CG ? B LYS 56 CG 123 1 Y 1 A LYS 29 ? CD ? B LYS 56 CD 124 1 Y 1 A LYS 29 ? CE ? B LYS 56 CE 125 1 Y 1 A LYS 29 ? NZ ? B LYS 56 NZ 126 1 Y 1 A LYS 47 ? CG ? B LYS 74 CG 127 1 Y 1 A LYS 47 ? CD ? B LYS 74 CD 128 1 Y 1 A LYS 47 ? CE ? B LYS 74 CE 129 1 Y 1 A LYS 47 ? NZ ? B LYS 74 NZ 130 1 Y 1 A ASP 48 ? CG ? B ASP 75 CG 131 1 Y 1 A ASP 48 ? OD1 ? B ASP 75 OD1 132 1 Y 1 A ASP 48 ? OD2 ? B ASP 75 OD2 133 1 Y 1 A GLU 56 ? CG ? B GLU 83 CG 134 1 Y 1 A GLU 56 ? CD ? B GLU 83 CD 135 1 Y 1 A GLU 56 ? OE1 ? B GLU 83 OE1 136 1 Y 1 A GLU 56 ? OE2 ? B GLU 83 OE2 137 1 Y 1 A VAL 58 ? CG1 ? B VAL 85 CG1 138 1 Y 1 A VAL 58 ? CG2 ? B VAL 85 CG2 139 1 Y 1 A GLU 59 ? CG ? B GLU 86 CG 140 1 Y 1 A GLU 59 ? CD ? B GLU 86 CD 141 1 Y 1 A GLU 59 ? OE1 ? B GLU 86 OE1 142 1 Y 1 A GLU 59 ? OE2 ? B GLU 86 OE2 143 1 Y 1 A ASN 90 ? CG ? B ASN 117 CG 144 1 Y 1 A ASN 90 ? OD1 ? B ASN 117 OD1 145 1 Y 1 A ASN 90 ? ND2 ? B ASN 117 ND2 146 1 Y 1 A ILE 120 ? CG1 ? B ILE 147 CG1 147 1 Y 1 A ILE 120 ? CG2 ? B ILE 147 CG2 148 1 Y 1 A ILE 120 ? CD1 ? B ILE 147 CD1 149 1 Y 1 A ASN 207 ? CG ? B ASN 234 CG 150 1 Y 1 A ASN 207 ? OD1 ? B ASN 234 OD1 151 1 Y 1 A ASN 207 ? ND2 ? B ASN 234 ND2 152 1 Y 1 A GLU 231 ? CG ? B GLU 258 CG 153 1 Y 1 A GLU 231 ? CD ? B GLU 258 CD 154 1 Y 1 A GLU 231 ? OE1 ? B GLU 258 OE1 155 1 Y 1 A GLU 231 ? OE2 ? B GLU 258 OE2 156 1 Y 1 A GLU 249 ? CG ? B GLU 276 CG 157 1 Y 1 A GLU 249 ? CD ? B GLU 276 CD 158 1 Y 1 A GLU 249 ? OE1 ? B GLU 276 OE1 159 1 Y 1 A GLU 249 ? OE2 ? B GLU 276 OE2 160 1 Y 1 A GLU 250 ? CG ? B GLU 277 CG 161 1 Y 1 A GLU 250 ? CD ? B GLU 277 CD 162 1 Y 1 A GLU 250 ? OE1 ? B GLU 277 OE1 163 1 Y 1 A GLU 250 ? OE2 ? B GLU 277 OE2 164 1 Y 1 A GLN 253 ? CG ? B GLN 280 CG 165 1 Y 1 A GLN 253 ? CD ? B GLN 280 CD 166 1 Y 1 A GLN 253 ? OE1 ? B GLN 280 OE1 167 1 Y 1 A GLN 253 ? NE2 ? B GLN 280 NE2 168 1 Y 1 A LYS 265 ? CG ? B LYS 292 CG 169 1 Y 1 A LYS 265 ? CD ? B LYS 292 CD 170 1 Y 1 A LYS 265 ? CE ? B LYS 292 CE 171 1 Y 1 A LYS 265 ? NZ ? B LYS 292 NZ 172 1 Y 1 A LYS 323 ? CG ? B LYS 350 CG 173 1 Y 1 A LYS 323 ? CD ? B LYS 350 CD 174 1 Y 1 A LYS 323 ? CE ? B LYS 350 CE 175 1 Y 1 A LYS 323 ? NZ ? B LYS 350 NZ 176 1 Y 1 A GLU 332 ? CG ? B GLU 359 CG 177 1 Y 1 A GLU 332 ? CD ? B GLU 359 CD 178 1 Y 1 A GLU 332 ? OE1 ? B GLU 359 OE1 179 1 Y 1 A GLU 332 ? OE2 ? B GLU 359 OE2 180 1 Y 1 A LYS 336 ? CG ? B LYS 363 CG 181 1 Y 1 A LYS 336 ? CD ? B LYS 363 CD 182 1 Y 1 A LYS 336 ? CE ? B LYS 363 CE 183 1 Y 1 A LYS 336 ? NZ ? B LYS 363 NZ 184 1 Y 1 A ARG 340 ? CG ? B ARG 367 CG 185 1 Y 1 A ARG 340 ? CD ? B ARG 367 CD 186 1 Y 1 A ARG 340 ? NE ? B ARG 367 NE 187 1 Y 1 A ARG 340 ? CZ ? B ARG 367 CZ 188 1 Y 1 A ARG 340 ? NH1 ? B ARG 367 NH1 189 1 Y 1 A ARG 340 ? NH2 ? B ARG 367 NH2 190 1 Y 1 A LYS 341 ? CG ? B LYS 368 CG 191 1 Y 1 A LYS 341 ? CD ? B LYS 368 CD 192 1 Y 1 A LYS 341 ? CE ? B LYS 368 CE 193 1 Y 1 A LYS 341 ? NZ ? B LYS 368 NZ 194 1 Y 1 A VAL 343 ? CG1 ? B VAL 370 CG1 195 1 Y 1 A VAL 343 ? CG2 ? B VAL 370 CG2 196 1 Y 1 A LYS 349 ? CG ? B LYS 376 CG 197 1 Y 1 A LYS 349 ? CD ? B LYS 376 CD 198 1 Y 1 A LYS 349 ? CE ? B LYS 376 CE 199 1 Y 1 A LYS 349 ? NZ ? B LYS 376 NZ 200 1 Y 1 A GLN 361 ? CG ? B GLN 388 CG 201 1 Y 1 A GLN 361 ? CD ? B GLN 388 CD 202 1 Y 1 A GLN 361 ? OE1 ? B GLN 388 OE1 203 1 Y 1 A GLN 361 ? NE2 ? B GLN 388 NE2 204 1 Y 1 A ARG 392 ? CG ? B ARG 419 CG 205 1 Y 1 A ARG 392 ? CD ? B ARG 419 CD 206 1 Y 1 A ARG 392 ? NE ? B ARG 419 NE 207 1 Y 1 A ARG 392 ? CZ ? B ARG 419 CZ 208 1 Y 1 A ARG 392 ? NH1 ? B ARG 419 NH1 209 1 Y 1 A ARG 392 ? NH2 ? B ARG 419 NH2 210 1 Y 1 A LEU 394 ? CG ? B LEU 421 CG 211 1 Y 1 A LEU 394 ? CD1 ? B LEU 421 CD1 212 1 Y 1 A LEU 394 ? CD2 ? B LEU 421 CD2 213 1 Y 1 A SER 402 ? OG ? B SER 429 OG 214 1 Y 1 A GLU 405 ? CG ? B GLU 432 CG 215 1 Y 1 A GLU 405 ? CD ? B GLU 432 CD 216 1 Y 1 A GLU 405 ? OE1 ? B GLU 432 OE1 217 1 Y 1 A GLU 405 ? OE2 ? B GLU 432 OE2 218 1 Y 1 A ARG 441 ? CG ? B ARG 468 CG 219 1 Y 1 A ARG 441 ? CD ? B ARG 468 CD 220 1 Y 1 A ARG 441 ? NE ? B ARG 468 NE 221 1 Y 1 A ARG 441 ? CZ ? B ARG 468 CZ 222 1 Y 1 A ARG 441 ? NH1 ? B ARG 468 NH1 223 1 Y 1 A ARG 441 ? NH2 ? B ARG 468 NH2 224 1 Y 1 A LYS 453 ? CG ? B LYS 480 CG 225 1 Y 1 A LYS 453 ? CD ? B LYS 480 CD 226 1 Y 1 A LYS 453 ? CE ? B LYS 480 CE 227 1 Y 1 A LYS 453 ? NZ ? B LYS 480 NZ 228 1 Y 1 A LYS 454 ? CG ? B LYS 481 CG 229 1 Y 1 A LYS 454 ? CD ? B LYS 481 CD 230 1 Y 1 A LYS 454 ? CE ? B LYS 481 CE 231 1 Y 1 A LYS 454 ? NZ ? B LYS 481 NZ 232 1 Y 1 A GLU 481 ? CG ? B GLU 508 CG 233 1 Y 1 A GLU 481 ? CD ? B GLU 508 CD 234 1 Y 1 A GLU 481 ? OE1 ? B GLU 508 OE1 235 1 Y 1 A GLU 481 ? OE2 ? B GLU 508 OE2 236 1 Y 1 A GLU 499 ? CG ? B GLU 526 CG 237 1 Y 1 A GLU 499 ? CD ? B GLU 526 CD 238 1 Y 1 A GLU 499 ? OE1 ? B GLU 526 OE1 239 1 Y 1 A GLU 499 ? OE2 ? B GLU 526 OE2 240 1 Y 1 A LYS 516 ? CG ? B LYS 543 CG 241 1 Y 1 A LYS 516 ? CD ? B LYS 543 CD 242 1 Y 1 A LYS 516 ? CE ? B LYS 543 CE 243 1 Y 1 A LYS 516 ? NZ ? B LYS 543 NZ 244 1 Y 1 A LYS 517 ? CG ? B LYS 544 CG 245 1 Y 1 A LYS 517 ? CD ? B LYS 544 CD 246 1 Y 1 A LYS 517 ? CE ? B LYS 544 CE 247 1 Y 1 A LYS 517 ? NZ ? B LYS 544 NZ 248 1 Y 1 A GLU 519 ? CG ? B GLU 546 CG 249 1 Y 1 A GLU 519 ? CD ? B GLU 546 CD 250 1 Y 1 A GLU 519 ? OE1 ? B GLU 546 OE1 251 1 Y 1 A GLU 519 ? OE2 ? B GLU 546 OE2 252 1 Y 1 A GLU 526 ? CG ? B GLU 553 CG 253 1 Y 1 A GLU 526 ? CD ? B GLU 553 CD 254 1 Y 1 A GLU 526 ? OE1 ? B GLU 553 OE1 255 1 Y 1 A GLU 526 ? OE2 ? B GLU 553 OE2 256 1 Y 1 A LYS 527 ? CG ? B LYS 554 CG 257 1 Y 1 A LYS 527 ? CD ? B LYS 554 CD 258 1 Y 1 A LYS 527 ? CE ? B LYS 554 CE 259 1 Y 1 A LYS 527 ? NZ ? B LYS 554 NZ 260 1 Y 1 A ARG 535 ? CG ? B ARG 562 CG 261 1 Y 1 A ARG 535 ? CD ? B ARG 562 CD 262 1 Y 1 A ARG 535 ? NE ? B ARG 562 NE 263 1 Y 1 A ARG 535 ? CZ ? B ARG 562 CZ 264 1 Y 1 A ARG 535 ? NH1 ? B ARG 562 NH1 265 1 Y 1 A ARG 535 ? NH2 ? B ARG 562 NH2 266 1 Y 1 A GLU 536 ? CG ? B GLU 563 CG 267 1 Y 1 A GLU 536 ? CD ? B GLU 563 CD 268 1 Y 1 A GLU 536 ? OE1 ? B GLU 563 OE1 269 1 Y 1 A GLU 536 ? OE2 ? B GLU 563 OE2 270 1 Y 1 A VAL 537 ? CG1 ? B VAL 564 CG1 271 1 Y 1 A VAL 537 ? CG2 ? B VAL 564 CG2 272 1 Y 1 A PRO 538 ? CG ? B PRO 565 CG 273 1 Y 1 A PRO 538 ? CD ? B PRO 565 CD # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 B MET -26 ? A MET 1 2 1 Y 1 B ARG -25 ? A ARG 2 3 1 Y 1 B LEU -24 ? A LEU 3 4 1 Y 1 B LEU -23 ? A LEU 4 5 1 Y 1 B THR -22 ? A THR 5 6 1 Y 1 B ALA -21 ? A ALA 6 7 1 Y 1 B LEU -20 ? A LEU 7 8 1 Y 1 B PHE -19 ? A PHE 8 9 1 Y 1 B ALA -18 ? A ALA 9 10 1 Y 1 B TYR -17 ? A TYR 10 11 1 Y 1 B PHE -16 ? A PHE 11 12 1 Y 1 B ILE -15 ? A ILE 12 13 1 Y 1 B VAL -14 ? A VAL 13 14 1 Y 1 B ALA -13 ? A ALA 14 15 1 Y 1 B LEU -12 ? A LEU 15 16 1 Y 1 B ILE -11 ? A ILE 16 17 1 Y 1 B LEU -10 ? A LEU 17 18 1 Y 1 B ALA -9 ? A ALA 18 19 1 Y 1 B PHE -8 ? A PHE 19 20 1 Y 1 B SER -7 ? A SER 20 21 1 Y 1 B VAL -6 ? A VAL 21 22 1 Y 1 B SER -5 ? A SER 22 23 1 Y 1 B ALA -4 ? A ALA 23 24 1 Y 1 B LYS -3 ? A LYS 24 25 1 Y 1 B SER -2 ? A SER 25 26 1 Y 1 B MET -1 ? A MET 26 27 1 Y 1 B HIS 0 ? A HIS 27 28 1 Y 1 B HIS 1 ? A HIS 28 29 1 Y 1 B HIS 2 ? A HIS 29 30 1 Y 1 B HIS 3 ? A HIS 30 31 1 Y 1 B HIS 4 ? A HIS 31 32 1 Y 1 B HIS 5 ? A HIS 32 33 1 Y 1 B HIS 6 ? A HIS 33 34 1 Y 1 B HIS 7 ? A HIS 34 35 1 Y 1 B SER 8 ? A SER 35 36 1 Y 1 B ALA 9 ? A ALA 36 37 1 Y 1 B TRP 10 ? A TRP 37 38 1 Y 1 B SER 11 ? A SER 38 39 1 Y 1 B HIS 12 ? A HIS 39 40 1 Y 1 B PRO 13 ? A PRO 40 41 1 Y 1 B GLN 14 ? A GLN 41 42 1 Y 1 B PHE 15 ? A PHE 42 43 1 Y 1 B GLU 16 ? A GLU 43 44 1 Y 1 B LYS 17 ? A LYS 44 45 1 Y 1 B GLU 18 ? A GLU 45 46 1 Y 1 B PHE 19 ? A PHE 46 47 1 Y 1 B TYR 20 ? A TYR 47 48 1 Y 1 B SER 122 ? A SER 149 49 1 Y 1 B LEU 123 ? A LEU 150 50 1 Y 1 B ASN 124 ? A ASN 151 51 1 Y 1 B LEU 125 ? A LEU 152 52 1 Y 1 B ASP 126 ? A ASP 153 53 1 Y 1 B GLU 127 ? A GLU 154 54 1 Y 1 B PHE 128 ? A PHE 155 55 1 Y 1 B CYS 129 ? A CYS 156 56 1 Y 1 B ASN 130 ? A ASN 157 57 1 Y 1 B CYS 131 ? A CYS 158 58 1 Y 1 B SER 132 ? A SER 159 59 1 Y 1 B GLU 133 ? A GLU 160 60 1 Y 1 B HIS 134 ? A HIS 161 61 1 Y 1 B ILE 135 ? A ILE 162 62 1 Y 1 B PRO 136 ? A PRO 163 63 1 Y 1 B GLU 362 ? A GLU 389 64 1 Y 1 B GLY 363 ? A GLY 390 65 1 Y 1 B ALA 364 ? A ALA 391 66 1 Y 1 B LYS 365 ? A LYS 392 67 1 Y 1 B GLY 366 ? A GLY 393 68 1 Y 1 B PRO 367 ? A PRO 394 69 1 Y 1 B LEU 368 ? A LEU 395 70 1 Y 1 B PRO 369 ? A PRO 396 71 1 Y 1 B VAL 370 ? A VAL 397 72 1 Y 1 B ASP 371 ? A ASP 398 73 1 Y 1 B THR 372 ? A THR 399 74 1 Y 1 B PHE 373 ? A PHE 400 75 1 Y 1 B LEU 374 ? A LEU 401 76 1 Y 1 B ARG 375 ? A ARG 402 77 1 Y 1 B GLY 376 ? A GLY 403 78 1 Y 1 B HIS 377 ? A HIS 404 79 1 Y 1 B GLU 378 ? A GLU 405 80 1 Y 1 B GLU 379 ? A GLU 406 81 1 Y 1 B SER 380 ? A SER 407 82 1 Y 1 B GLY 381 ? A GLY 408 83 1 Y 1 B ASP 382 ? A ASP 409 84 1 Y 1 B ARG 383 ? A ARG 410 85 1 Y 1 B PHE 384 ? A PHE 411 86 1 Y 1 B SER 385 ? A SER 412 87 1 Y 1 B ASN 386 ? A ASN 413 88 1 Y 1 B SER 387 ? A SER 414 89 1 Y 1 B SER 388 ? A SER 415 90 1 Y 1 B THR 389 ? A THR 416 91 1 Y 1 B ALA 390 ? A ALA 417 92 1 Y 1 B ARG 535 ? A ARG 562 93 1 Y 1 B GLU 536 ? A GLU 563 94 1 Y 1 B VAL 537 ? A VAL 564 95 1 Y 1 B PRO 538 ? A PRO 565 96 1 Y 1 B PHE 539 ? A PHE 566 97 1 Y 1 B SER 540 ? A SER 567 98 1 Y 1 B ASN 541 ? A ASN 568 99 1 Y 1 A MET -26 ? B MET 1 100 1 Y 1 A ARG -25 ? B ARG 2 101 1 Y 1 A LEU -24 ? B LEU 3 102 1 Y 1 A LEU -23 ? B LEU 4 103 1 Y 1 A THR -22 ? B THR 5 104 1 Y 1 A ALA -21 ? B ALA 6 105 1 Y 1 A LEU -20 ? B LEU 7 106 1 Y 1 A PHE -19 ? B PHE 8 107 1 Y 1 A ALA -18 ? B ALA 9 108 1 Y 1 A TYR -17 ? B TYR 10 109 1 Y 1 A PHE -16 ? B PHE 11 110 1 Y 1 A ILE -15 ? B ILE 12 111 1 Y 1 A VAL -14 ? B VAL 13 112 1 Y 1 A ALA -13 ? B ALA 14 113 1 Y 1 A LEU -12 ? B LEU 15 114 1 Y 1 A ILE -11 ? B ILE 16 115 1 Y 1 A LEU -10 ? B LEU 17 116 1 Y 1 A ALA -9 ? B ALA 18 117 1 Y 1 A PHE -8 ? B PHE 19 118 1 Y 1 A SER -7 ? B SER 20 119 1 Y 1 A VAL -6 ? B VAL 21 120 1 Y 1 A SER -5 ? B SER 22 121 1 Y 1 A ALA -4 ? B ALA 23 122 1 Y 1 A LYS -3 ? B LYS 24 123 1 Y 1 A SER -2 ? B SER 25 124 1 Y 1 A MET -1 ? B MET 26 125 1 Y 1 A HIS 0 ? B HIS 27 126 1 Y 1 A HIS 1 ? B HIS 28 127 1 Y 1 A HIS 2 ? B HIS 29 128 1 Y 1 A HIS 3 ? B HIS 30 129 1 Y 1 A HIS 4 ? B HIS 31 130 1 Y 1 A HIS 5 ? B HIS 32 131 1 Y 1 A HIS 6 ? B HIS 33 132 1 Y 1 A HIS 7 ? B HIS 34 133 1 Y 1 A SER 8 ? B SER 35 134 1 Y 1 A ALA 9 ? B ALA 36 135 1 Y 1 A TRP 10 ? B TRP 37 136 1 Y 1 A SER 11 ? B SER 38 137 1 Y 1 A HIS 12 ? B HIS 39 138 1 Y 1 A PRO 13 ? B PRO 40 139 1 Y 1 A GLN 14 ? B GLN 41 140 1 Y 1 A PHE 15 ? B PHE 42 141 1 Y 1 A GLU 16 ? B GLU 43 142 1 Y 1 A LYS 17 ? B LYS 44 143 1 Y 1 A GLU 18 ? B GLU 45 144 1 Y 1 A PHE 19 ? B PHE 46 145 1 Y 1 A TYR 20 ? B TYR 47 146 1 Y 1 A GLY 21 ? B GLY 48 147 1 Y 1 A SER 122 ? B SER 149 148 1 Y 1 A LEU 123 ? B LEU 150 149 1 Y 1 A ASN 124 ? B ASN 151 150 1 Y 1 A LEU 125 ? B LEU 152 151 1 Y 1 A ASP 126 ? B ASP 153 152 1 Y 1 A GLU 127 ? B GLU 154 153 1 Y 1 A PHE 128 ? B PHE 155 154 1 Y 1 A CYS 129 ? B CYS 156 155 1 Y 1 A ASN 130 ? B ASN 157 156 1 Y 1 A CYS 131 ? B CYS 158 157 1 Y 1 A SER 132 ? B SER 159 158 1 Y 1 A GLU 133 ? B GLU 160 159 1 Y 1 A HIS 134 ? B HIS 161 160 1 Y 1 A ILE 135 ? B ILE 162 161 1 Y 1 A PRO 136 ? B PRO 163 162 1 Y 1 A GLU 362 ? B GLU 389 163 1 Y 1 A GLY 363 ? B GLY 390 164 1 Y 1 A ALA 364 ? B ALA 391 165 1 Y 1 A LYS 365 ? B LYS 392 166 1 Y 1 A GLY 366 ? B GLY 393 167 1 Y 1 A PRO 367 ? B PRO 394 168 1 Y 1 A LEU 368 ? B LEU 395 169 1 Y 1 A PRO 369 ? B PRO 396 170 1 Y 1 A VAL 370 ? B VAL 397 171 1 Y 1 A ASP 371 ? B ASP 398 172 1 Y 1 A THR 372 ? B THR 399 173 1 Y 1 A PHE 373 ? B PHE 400 174 1 Y 1 A LEU 374 ? B LEU 401 175 1 Y 1 A ARG 375 ? B ARG 402 176 1 Y 1 A GLY 376 ? B GLY 403 177 1 Y 1 A HIS 377 ? B HIS 404 178 1 Y 1 A GLU 378 ? B GLU 405 179 1 Y 1 A GLU 379 ? B GLU 406 180 1 Y 1 A SER 380 ? B SER 407 181 1 Y 1 A GLY 381 ? B GLY 408 182 1 Y 1 A ASP 382 ? B ASP 409 183 1 Y 1 A ARG 383 ? B ARG 410 184 1 Y 1 A PHE 384 ? B PHE 411 185 1 Y 1 A SER 385 ? B SER 412 186 1 Y 1 A ASN 386 ? B ASN 413 187 1 Y 1 A SER 387 ? B SER 414 188 1 Y 1 A SER 388 ? B SER 415 189 1 Y 1 A THR 389 ? B THR 416 190 1 Y 1 A ALA 390 ? B ALA 417 191 1 Y 1 A PHE 391 ? B PHE 418 192 1 Y 1 A PHE 539 ? B PHE 566 193 1 Y 1 A SER 540 ? B SER 567 194 1 Y 1 A ASN 541 ? B ASN 568 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 'GADOLINIUM ION' GD3 3 'MAGNESIUM ION' MG 4 'BICARBONATE ION' BCT 5 'CHLORIDE ION' CL 6 N-ACETYL-D-GLUCOSAMINE NAG 7 CYCLOMETHYLTRYPTOPHAN TCR 8 water HOH #