data_5EOD # _entry.id 5EOD # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 5EOD WWPDB D_1000215261 # _pdbx_database_status.status_code REL _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.entry_id 5EOD _pdbx_database_status.recvd_initial_deposition_date 2015-11-10 _pdbx_database_status.SG_entry N _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site PDBE _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? _pdbx_database_status.pdb_format_compatible Y # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Wong, S.S.' 1 'Ostergaard, S.' 2 'Hall, G.' 3 'Li, C.' 4 'Williams, P.M.' 5 'Stennicke, H.' 6 'Emsley, J.' 7 # _citation.abstract ? _citation.abstract_id_CAS ? _citation.book_id_ISBN ? _citation.book_publisher ? _citation.book_publisher_city ? _citation.book_title ? _citation.coordinate_linkage ? _citation.country US _citation.database_id_Medline ? _citation.details ? _citation.id primary _citation.journal_abbrev Blood _citation.journal_id_ASTM ? _citation.journal_id_CSD ? _citation.journal_id_ISSN 1528-0020 _citation.journal_full ? _citation.journal_issue ? _citation.journal_volume 127 _citation.language ? _citation.page_first 2915 _citation.page_last 2923 _citation.title 'A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain.' _citation.year 2016 _citation.database_id_CSD ? _citation.pdbx_database_id_DOI 10.1182/blood-2015-10-676122 _citation.pdbx_database_id_PubMed 27006387 _citation.unpublished_flag ? # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Wong, S.S.' 1 primary 'stergaard, S.' 2 primary 'Hall, G.' 3 primary 'Li, C.' 4 primary 'Williams, P.M.' 5 primary 'Stennicke, H.' 6 primary 'Emsley, J.' 7 # _cell.angle_alpha 90.00 _cell.angle_alpha_esd ? _cell.angle_beta 90.00 _cell.angle_beta_esd ? _cell.angle_gamma 90.00 _cell.angle_gamma_esd ? _cell.entry_id 5EOD _cell.details ? _cell.formula_units_Z ? _cell.length_a 81.065 _cell.length_a_esd ? _cell.length_b 81.065 _cell.length_b_esd ? _cell.length_c 253.084 _cell.length_c_esd ? _cell.volume ? _cell.volume_esd ? _cell.Z_PDB 8 _cell.reciprocal_angle_alpha ? _cell.reciprocal_angle_beta ? _cell.reciprocal_angle_gamma ? _cell.reciprocal_angle_alpha_esd ? _cell.reciprocal_angle_beta_esd ? _cell.reciprocal_angle_gamma_esd ? _cell.reciprocal_length_a ? _cell.reciprocal_length_b ? _cell.reciprocal_length_c ? _cell.reciprocal_length_a_esd ? _cell.reciprocal_length_b_esd ? _cell.reciprocal_length_c_esd ? _cell.pdbx_unique_axis ? # _symmetry.entry_id 5EOD _symmetry.cell_setting ? _symmetry.Int_Tables_number 96 _symmetry.space_group_name_Hall ? _symmetry.space_group_name_H-M 'P 43 21 2' _symmetry.pdbx_full_space_group_name_H-M ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'Coagulation factor XI' 67987.500 1 3.4.21.27 ? ? ? 2 polymer man LP2 750.794 1 ? ? ? ? 3 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 3 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name 'FXI,Plasma thromboplastin antecedent,PTA' # loop_ _entity_poly.entity_id _entity_poly.type _entity_poly.nstd_linkage _entity_poly.nstd_monomer _entity_poly.pdbx_seq_one_letter_code _entity_poly.pdbx_seq_one_letter_code_can _entity_poly.pdbx_strand_id _entity_poly.pdbx_target_identifier 1 'polypeptide(L)' no no ;CVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYS FKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRIT KLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKT SESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASC NEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGS IIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPI CLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPL SCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV ; ;CVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYS FKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRIT KLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKT SESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASC NEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGS IIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPI CLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPL SCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV ; A ? 2 'polypeptide(L)' no no EFPDFP EFPDFP B ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 CYS n 1 2 VAL n 1 3 THR n 1 4 GLN n 1 5 LEU n 1 6 LEU n 1 7 LYS n 1 8 ASP n 1 9 THR n 1 10 CYS n 1 11 PHE n 1 12 GLU n 1 13 GLY n 1 14 GLY n 1 15 ASP n 1 16 ILE n 1 17 THR n 1 18 THR n 1 19 VAL n 1 20 PHE n 1 21 THR n 1 22 PRO n 1 23 SER n 1 24 ALA n 1 25 LYS n 1 26 TYR n 1 27 CYS n 1 28 GLN n 1 29 VAL n 1 30 VAL n 1 31 CYS n 1 32 THR n 1 33 TYR n 1 34 HIS n 1 35 PRO n 1 36 ARG n 1 37 CYS n 1 38 LEU n 1 39 LEU n 1 40 PHE n 1 41 THR n 1 42 PHE n 1 43 THR n 1 44 ALA n 1 45 GLU n 1 46 SER n 1 47 PRO n 1 48 SER n 1 49 GLU n 1 50 ASP n 1 51 PRO n 1 52 THR n 1 53 ARG n 1 54 TRP n 1 55 PHE n 1 56 THR n 1 57 CYS n 1 58 VAL n 1 59 LEU n 1 60 LYS n 1 61 ASP n 1 62 SER n 1 63 VAL n 1 64 THR n 1 65 GLU n 1 66 THR n 1 67 LEU n 1 68 PRO n 1 69 ARG n 1 70 VAL n 1 71 ASN n 1 72 ARG n 1 73 THR n 1 74 ALA n 1 75 ALA n 1 76 ILE n 1 77 SER n 1 78 GLY n 1 79 TYR n 1 80 SER n 1 81 PHE n 1 82 LYS n 1 83 GLN n 1 84 CYS n 1 85 SER n 1 86 HIS n 1 87 GLN n 1 88 ILE n 1 89 SER n 1 90 ALA n 1 91 CYS n 1 92 ASN n 1 93 LYS n 1 94 ASP n 1 95 ILE n 1 96 TYR n 1 97 VAL n 1 98 ASP n 1 99 LEU n 1 100 ASP n 1 101 MET n 1 102 LYS n 1 103 GLY n 1 104 ILE n 1 105 ASN n 1 106 TYR n 1 107 ASN n 1 108 SER n 1 109 SER n 1 110 VAL n 1 111 ALA n 1 112 LYS n 1 113 SER n 1 114 ALA n 1 115 GLN n 1 116 GLU n 1 117 CYS n 1 118 GLN n 1 119 GLU n 1 120 ARG n 1 121 CYS n 1 122 THR n 1 123 ASP n 1 124 ASP n 1 125 VAL n 1 126 HIS n 1 127 CYS n 1 128 HIS n 1 129 PHE n 1 130 PHE n 1 131 THR n 1 132 TYR n 1 133 ALA n 1 134 THR n 1 135 ARG n 1 136 GLN n 1 137 PHE n 1 138 PRO n 1 139 SER n 1 140 LEU n 1 141 GLU n 1 142 HIS n 1 143 ARG n 1 144 ASN n 1 145 ILE n 1 146 CYS n 1 147 LEU n 1 148 LEU n 1 149 LYS n 1 150 HIS n 1 151 THR n 1 152 GLN n 1 153 THR n 1 154 GLY n 1 155 THR n 1 156 PRO n 1 157 THR n 1 158 ARG n 1 159 ILE n 1 160 THR n 1 161 LYS n 1 162 LEU n 1 163 ASP n 1 164 LYS n 1 165 VAL n 1 166 VAL n 1 167 SER n 1 168 GLY n 1 169 PHE n 1 170 SER n 1 171 LEU n 1 172 LYS n 1 173 SER n 1 174 CYS n 1 175 ALA n 1 176 LEU n 1 177 SER n 1 178 ASN n 1 179 LEU n 1 180 ALA n 1 181 CYS n 1 182 ILE n 1 183 ARG n 1 184 ASP n 1 185 ILE n 1 186 PHE n 1 187 PRO n 1 188 ASN n 1 189 THR n 1 190 VAL n 1 191 PHE n 1 192 ALA n 1 193 ASP n 1 194 SER n 1 195 ASN n 1 196 ILE n 1 197 ASP n 1 198 SER n 1 199 VAL n 1 200 MET n 1 201 ALA n 1 202 PRO n 1 203 ASP n 1 204 ALA n 1 205 PHE n 1 206 VAL n 1 207 CYS n 1 208 GLY n 1 209 ARG n 1 210 ILE n 1 211 CYS n 1 212 THR n 1 213 HIS n 1 214 HIS n 1 215 PRO n 1 216 GLY n 1 217 CYS n 1 218 LEU n 1 219 PHE n 1 220 PHE n 1 221 THR n 1 222 PHE n 1 223 PHE n 1 224 SER n 1 225 GLN n 1 226 GLU n 1 227 TRP n 1 228 PRO n 1 229 LYS n 1 230 GLU n 1 231 SER n 1 232 GLN n 1 233 ARG n 1 234 ASN n 1 235 LEU n 1 236 CYS n 1 237 LEU n 1 238 LEU n 1 239 LYS n 1 240 THR n 1 241 SER n 1 242 GLU n 1 243 SER n 1 244 GLY n 1 245 LEU n 1 246 PRO n 1 247 SER n 1 248 THR n 1 249 ARG n 1 250 ILE n 1 251 LYS n 1 252 LYS n 1 253 SER n 1 254 LYS n 1 255 ALA n 1 256 LEU n 1 257 SER n 1 258 GLY n 1 259 PHE n 1 260 SER n 1 261 LEU n 1 262 GLN n 1 263 SER n 1 264 CYS n 1 265 ARG n 1 266 HIS n 1 267 SER n 1 268 ILE n 1 269 PRO n 1 270 VAL n 1 271 PHE n 1 272 CYS n 1 273 HIS n 1 274 SER n 1 275 SER n 1 276 PHE n 1 277 TYR n 1 278 HIS n 1 279 ASP n 1 280 THR n 1 281 ASP n 1 282 PHE n 1 283 LEU n 1 284 GLY n 1 285 GLU n 1 286 GLU n 1 287 LEU n 1 288 ASP n 1 289 ILE n 1 290 VAL n 1 291 ALA n 1 292 ALA n 1 293 LYS n 1 294 SER n 1 295 HIS n 1 296 GLU n 1 297 ALA n 1 298 CYS n 1 299 GLN n 1 300 LYS n 1 301 LEU n 1 302 CYS n 1 303 THR n 1 304 ASN n 1 305 ALA n 1 306 VAL n 1 307 ARG n 1 308 CYS n 1 309 GLN n 1 310 PHE n 1 311 PHE n 1 312 THR n 1 313 TYR n 1 314 THR n 1 315 PRO n 1 316 ALA n 1 317 GLN n 1 318 ALA n 1 319 SER n 1 320 CYS n 1 321 ASN n 1 322 GLU n 1 323 GLY n 1 324 LYS n 1 325 GLY n 1 326 LYS n 1 327 CYS n 1 328 TYR n 1 329 LEU n 1 330 LYS n 1 331 LEU n 1 332 SER n 1 333 SER n 1 334 ASN n 1 335 GLY n 1 336 SER n 1 337 PRO n 1 338 THR n 1 339 LYS n 1 340 ILE n 1 341 LEU n 1 342 HIS n 1 343 GLY n 1 344 ARG n 1 345 GLY n 1 346 GLY n 1 347 ILE n 1 348 SER n 1 349 GLY n 1 350 TYR n 1 351 THR n 1 352 LEU n 1 353 ARG n 1 354 LEU n 1 355 CYS n 1 356 LYS n 1 357 MET n 1 358 ASP n 1 359 ASN n 1 360 GLU n 1 361 CYS n 1 362 THR n 1 363 THR n 1 364 LYS n 1 365 ILE n 1 366 LYS n 1 367 PRO n 1 368 ARG n 1 369 ILE n 1 370 VAL n 1 371 GLY n 1 372 GLY n 1 373 THR n 1 374 ALA n 1 375 SER n 1 376 VAL n 1 377 ARG n 1 378 GLY n 1 379 GLU n 1 380 TRP n 1 381 PRO n 1 382 TRP n 1 383 GLN n 1 384 VAL n 1 385 THR n 1 386 LEU n 1 387 HIS n 1 388 THR n 1 389 THR n 1 390 SER n 1 391 PRO n 1 392 THR n 1 393 GLN n 1 394 ARG n 1 395 HIS n 1 396 LEU n 1 397 CYS n 1 398 GLY n 1 399 GLY n 1 400 SER n 1 401 ILE n 1 402 ILE n 1 403 GLY n 1 404 ASN n 1 405 GLN n 1 406 TRP n 1 407 ILE n 1 408 LEU n 1 409 THR n 1 410 ALA n 1 411 ALA n 1 412 HIS n 1 413 CYS n 1 414 PHE n 1 415 TYR n 1 416 GLY n 1 417 VAL n 1 418 GLU n 1 419 SER n 1 420 PRO n 1 421 LYS n 1 422 ILE n 1 423 LEU n 1 424 ARG n 1 425 VAL n 1 426 TYR n 1 427 SER n 1 428 GLY n 1 429 ILE n 1 430 LEU n 1 431 ASN n 1 432 GLN n 1 433 SER n 1 434 GLU n 1 435 ILE n 1 436 LYS n 1 437 GLU n 1 438 ASP n 1 439 THR n 1 440 SER n 1 441 PHE n 1 442 PHE n 1 443 GLY n 1 444 VAL n 1 445 GLN n 1 446 GLU n 1 447 ILE n 1 448 ILE n 1 449 ILE n 1 450 HIS n 1 451 ASP n 1 452 GLN n 1 453 TYR n 1 454 LYS n 1 455 MET n 1 456 ALA n 1 457 GLU n 1 458 SER n 1 459 GLY n 1 460 TYR n 1 461 ASP n 1 462 ILE n 1 463 ALA n 1 464 LEU n 1 465 LEU n 1 466 LYS n 1 467 LEU n 1 468 GLU n 1 469 THR n 1 470 THR n 1 471 VAL n 1 472 ASN n 1 473 TYR n 1 474 THR n 1 475 ASP n 1 476 SER n 1 477 GLN n 1 478 ARG n 1 479 PRO n 1 480 ILE n 1 481 CYS n 1 482 LEU n 1 483 PRO n 1 484 SER n 1 485 LYS n 1 486 GLY n 1 487 ASP n 1 488 ARG n 1 489 ASN n 1 490 VAL n 1 491 ILE n 1 492 TYR n 1 493 THR n 1 494 ASP n 1 495 CYS n 1 496 TRP n 1 497 VAL n 1 498 THR n 1 499 GLY n 1 500 TRP n 1 501 GLY n 1 502 TYR n 1 503 ARG n 1 504 LYS n 1 505 LEU n 1 506 ARG n 1 507 ASP n 1 508 LYS n 1 509 ILE n 1 510 GLN n 1 511 ASN n 1 512 THR n 1 513 LEU n 1 514 GLN n 1 515 LYS n 1 516 ALA n 1 517 LYS n 1 518 ILE n 1 519 PRO n 1 520 LEU n 1 521 VAL n 1 522 THR n 1 523 ASN n 1 524 GLU n 1 525 GLU n 1 526 CYS n 1 527 GLN n 1 528 LYS n 1 529 ARG n 1 530 TYR n 1 531 ARG n 1 532 GLY n 1 533 HIS n 1 534 LYS n 1 535 ILE n 1 536 THR n 1 537 HIS n 1 538 LYS n 1 539 MET n 1 540 ILE n 1 541 CYS n 1 542 ALA n 1 543 GLY n 1 544 TYR n 1 545 ARG n 1 546 GLU n 1 547 GLY n 1 548 GLY n 1 549 LYS n 1 550 ASP n 1 551 ALA n 1 552 CYS n 1 553 LYS n 1 554 GLY n 1 555 ASP n 1 556 SER n 1 557 GLY n 1 558 GLY n 1 559 PRO n 1 560 LEU n 1 561 SER n 1 562 CYS n 1 563 LYS n 1 564 HIS n 1 565 ASN n 1 566 GLU n 1 567 VAL n 1 568 TRP n 1 569 HIS n 1 570 LEU n 1 571 VAL n 1 572 GLY n 1 573 ILE n 1 574 THR n 1 575 SER n 1 576 TRP n 1 577 GLY n 1 578 GLU n 1 579 GLY n 1 580 CYS n 1 581 ALA n 1 582 GLN n 1 583 ARG n 1 584 GLU n 1 585 ARG n 1 586 PRO n 1 587 GLY n 1 588 VAL n 1 589 TYR n 1 590 THR n 1 591 ASN n 1 592 VAL n 1 593 VAL n 1 594 GLU n 1 595 TYR n 1 596 VAL n 1 597 ASP n 1 598 TRP n 1 599 ILE n 1 600 LEU n 1 601 GLU n 1 602 LYS n 1 603 THR n 1 604 GLN n 1 605 ALA n 1 606 VAL n 2 1 GLU n 2 2 PHE n 2 3 PRO n 2 4 ASP n 2 5 PHE n 2 6 PRO n # loop_ _entity_src_gen.entity_id _entity_src_gen.pdbx_src_id _entity_src_gen.pdbx_alt_source_flag _entity_src_gen.pdbx_seq_type _entity_src_gen.pdbx_beg_seq_num _entity_src_gen.pdbx_end_seq_num _entity_src_gen.gene_src_common_name _entity_src_gen.gene_src_genus _entity_src_gen.pdbx_gene_src_gene _entity_src_gen.gene_src_species _entity_src_gen.gene_src_strain _entity_src_gen.gene_src_tissue _entity_src_gen.gene_src_tissue_fraction _entity_src_gen.gene_src_details _entity_src_gen.pdbx_gene_src_fragment _entity_src_gen.pdbx_gene_src_scientific_name _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id _entity_src_gen.pdbx_gene_src_variant _entity_src_gen.pdbx_gene_src_cell_line _entity_src_gen.pdbx_gene_src_atcc _entity_src_gen.pdbx_gene_src_organ _entity_src_gen.pdbx_gene_src_organelle _entity_src_gen.pdbx_gene_src_cell _entity_src_gen.pdbx_gene_src_cellular_location _entity_src_gen.host_org_common_name _entity_src_gen.pdbx_host_org_scientific_name _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id _entity_src_gen.host_org_genus _entity_src_gen.pdbx_host_org_gene _entity_src_gen.pdbx_host_org_organ _entity_src_gen.host_org_species _entity_src_gen.pdbx_host_org_tissue _entity_src_gen.pdbx_host_org_tissue_fraction _entity_src_gen.pdbx_host_org_strain _entity_src_gen.pdbx_host_org_variant _entity_src_gen.pdbx_host_org_cell_line _entity_src_gen.pdbx_host_org_atcc _entity_src_gen.pdbx_host_org_culture_collection _entity_src_gen.pdbx_host_org_cell _entity_src_gen.pdbx_host_org_organelle _entity_src_gen.pdbx_host_org_cellular_location _entity_src_gen.pdbx_host_org_vector_type _entity_src_gen.pdbx_host_org_vector _entity_src_gen.host_org_details _entity_src_gen.expression_system_id _entity_src_gen.plasmid_name _entity_src_gen.plasmid_details _entity_src_gen.pdbx_description 1 1 sample 'Biological sequence' 1 606 Human ? F11 ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? 'chinese hamster' 'Cricetulus griseus' 10029 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 2 1 sample 'Biological sequence' 1 6 ? ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'synthetic construct' 32630 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? # loop_ _struct_ref.id _struct_ref.db_name _struct_ref.db_code _struct_ref.pdbx_db_accession _struct_ref.pdbx_db_isoform _struct_ref.entity_id _struct_ref.pdbx_seq_one_letter_code _struct_ref.pdbx_align_begin 1 UNP FA11_HUMAN P03951 ? 1 ;CVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYS FKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRIT KLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKT SESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASC NEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGS IIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPI CLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPL SCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV ; 20 2 PDB 5EOD 5EOD ? 2 ? 1 # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 5EOD A 1 ? 606 ? P03951 20 ? 625 ? 2 607 2 2 5EOD B 1 ? 6 ? 5EOD 0 ? 5 ? 0 5 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.absorpt_coefficient_mu ? _exptl.absorpt_correction_T_max ? _exptl.absorpt_correction_T_min ? _exptl.absorpt_correction_type ? _exptl.absorpt_process_details ? _exptl.entry_id 5EOD _exptl.crystals_number ? _exptl.details ? _exptl.method 'X-RAY DIFFRACTION' _exptl.method_details ? # _exptl_crystal.colour ? _exptl_crystal.density_diffrn ? _exptl_crystal.density_Matthews 3.1 _exptl_crystal.density_method ? _exptl_crystal.density_percent_sol 61 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.id 1 _exptl_crystal.preparation ? _exptl_crystal.size_max ? _exptl_crystal.size_mid ? _exptl_crystal.size_min ? _exptl_crystal.size_rad ? _exptl_crystal.colour_lustre ? _exptl_crystal.colour_modifier ? _exptl_crystal.colour_primary ? _exptl_crystal.density_meas ? _exptl_crystal.density_meas_esd ? _exptl_crystal.density_meas_gt ? _exptl_crystal.density_meas_lt ? _exptl_crystal.density_meas_temp ? _exptl_crystal.density_meas_temp_esd ? _exptl_crystal.density_meas_temp_gt ? _exptl_crystal.density_meas_temp_lt ? _exptl_crystal.pdbx_crystal_image_url ? _exptl_crystal.pdbx_crystal_image_format ? _exptl_crystal.pdbx_mosaicity ? _exptl_crystal.pdbx_mosaicity_esd ? # _exptl_crystal_grow.apparatus ? _exptl_crystal_grow.atmosphere ? _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.details ? _exptl_crystal_grow.method 'VAPOR DIFFUSION, SITTING DROP' _exptl_crystal_grow.method_ref ? _exptl_crystal_grow.pH 7.5 _exptl_crystal_grow.pressure ? _exptl_crystal_grow.pressure_esd ? _exptl_crystal_grow.seeding ? _exptl_crystal_grow.seeding_ref ? _exptl_crystal_grow.temp 293.15 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.temp_esd ? _exptl_crystal_grow.time ? _exptl_crystal_grow.pdbx_details '0.1M HEPES pH7.5, 20% PEG1500,' _exptl_crystal_grow.pdbx_pH_range ? # _diffrn.ambient_environment ? _diffrn.ambient_temp 80 _diffrn.ambient_temp_details ? _diffrn.ambient_temp_esd ? _diffrn.crystal_id 1 _diffrn.crystal_support ? _diffrn.crystal_treatment ? _diffrn.details ? _diffrn.id 1 _diffrn.ambient_pressure ? _diffrn.ambient_pressure_esd ? _diffrn.ambient_pressure_gt ? _diffrn.ambient_pressure_lt ? _diffrn.ambient_temp_gt ? _diffrn.ambient_temp_lt ? # _diffrn_detector.details ? _diffrn_detector.detector PIXEL _diffrn_detector.diffrn_id 1 _diffrn_detector.type 'DECTRIS PILATUS 6M-F' _diffrn_detector.area_resol_mean ? _diffrn_detector.dtime ? _diffrn_detector.pdbx_frames_total ? _diffrn_detector.pdbx_collection_time_total ? _diffrn_detector.pdbx_collection_date 2012-10-12 # _diffrn_radiation.collimation ? _diffrn_radiation.diffrn_id 1 _diffrn_radiation.filter_edge ? _diffrn_radiation.inhomogeneity ? _diffrn_radiation.monochromator 'Double mirror' _diffrn_radiation.polarisn_norm ? _diffrn_radiation.polarisn_ratio ? _diffrn_radiation.probe ? _diffrn_radiation.type ? _diffrn_radiation.xray_symbol ? _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.pdbx_wavelength_list ? _diffrn_radiation.pdbx_wavelength ? _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_analyzer ? _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.976 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.current ? _diffrn_source.details ? _diffrn_source.diffrn_id 1 _diffrn_source.power ? _diffrn_source.size ? _diffrn_source.source SYNCHROTRON _diffrn_source.target ? _diffrn_source.type 'DIAMOND BEAMLINE I04' _diffrn_source.voltage ? _diffrn_source.take-off_angle ? _diffrn_source.pdbx_wavelength_list 0.976 _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_synchrotron_beamline I04 _diffrn_source.pdbx_synchrotron_site Diamond # _reflns.B_iso_Wilson_estimate ? _reflns.entry_id 5EOD _reflns.data_reduction_details ? _reflns.data_reduction_method ? _reflns.d_resolution_high 2.97 _reflns.d_resolution_low 47.4 _reflns.details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.number_all 18287 _reflns.number_obs 18287 _reflns.observed_criterion ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.observed_criterion_I_max ? _reflns.observed_criterion_I_min ? _reflns.observed_criterion_sigma_F ? _reflns.observed_criterion_sigma_I ? _reflns.percent_possible_obs 99.8 _reflns.R_free_details ? _reflns.Rmerge_F_all ? _reflns.Rmerge_F_obs ? _reflns.Friedel_coverage ? _reflns.number_gt ? _reflns.threshold_expression ? _reflns.pdbx_redundancy 9.8 _reflns.pdbx_Rmerge_I_obs 0.149 _reflns.pdbx_Rmerge_I_all ? _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_av_sigmaI ? _reflns.pdbx_netI_over_sigmaI 12.5 _reflns.pdbx_res_netI_over_av_sigmaI_2 ? _reflns.pdbx_res_netI_over_sigmaI_2 ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_d_res_high_opt ? _reflns.pdbx_d_res_low_opt ? _reflns.pdbx_d_res_opt_method ? _reflns.phase_calculation_details ? _reflns.pdbx_Rrim_I_all ? _reflns.pdbx_Rpim_I_all ? _reflns.pdbx_d_opt ? _reflns.pdbx_number_measured_all ? _reflns.pdbx_diffrn_id 1 _reflns.pdbx_ordinal 1 _reflns.pdbx_CC_half ? _reflns.pdbx_R_split ? # _reflns_shell.d_res_high 2.97 _reflns_shell.d_res_low 3.13 _reflns_shell.meanI_over_sigI_all ? _reflns_shell.meanI_over_sigI_obs 3.1 _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_possible ? _reflns_shell.number_unique_all ? _reflns_shell.number_unique_obs ? _reflns_shell.percent_possible_all 98.9 _reflns_shell.percent_possible_obs ? _reflns_shell.Rmerge_F_all ? _reflns_shell.Rmerge_F_obs ? _reflns_shell.Rmerge_I_all ? _reflns_shell.Rmerge_I_obs 0.714 _reflns_shell.meanI_over_sigI_gt ? _reflns_shell.meanI_over_uI_all ? _reflns_shell.meanI_over_uI_gt ? _reflns_shell.number_measured_gt ? _reflns_shell.number_unique_gt ? _reflns_shell.percent_possible_gt ? _reflns_shell.Rmerge_F_gt ? _reflns_shell.Rmerge_I_gt ? _reflns_shell.pdbx_redundancy 9.1 _reflns_shell.pdbx_Rsym_value ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_netI_over_sigmaI_all ? _reflns_shell.pdbx_netI_over_sigmaI_obs ? _reflns_shell.pdbx_Rrim_I_all ? _reflns_shell.pdbx_Rpim_I_all ? _reflns_shell.pdbx_rejects ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 _reflns_shell.pdbx_CC_half ? _reflns_shell.pdbx_R_split ? # _refine.aniso_B[1][1] -0.43 _refine.aniso_B[1][2] 0.00 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][2] -0.43 _refine.aniso_B[2][3] 0.00 _refine.aniso_B[3][3] 0.86 _refine.B_iso_max ? _refine.B_iso_mean 76.646 _refine.B_iso_min ? _refine.correlation_coeff_Fo_to_Fc 0.943 _refine.correlation_coeff_Fo_to_Fc_free 0.881 _refine.details 'HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT' _refine.diff_density_max ? _refine.diff_density_max_esd ? _refine.diff_density_min ? _refine.diff_density_min_esd ? _refine.diff_density_rms ? _refine.diff_density_rms_esd ? _refine.entry_id 5EOD _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.ls_abs_structure_details ? _refine.ls_abs_structure_Flack ? _refine.ls_abs_structure_Flack_esd ? _refine.ls_abs_structure_Rogers ? _refine.ls_abs_structure_Rogers_esd ? _refine.ls_d_res_high 3.10 _refine.ls_d_res_low 47.4 _refine.ls_extinction_coef ? _refine.ls_extinction_coef_esd ? _refine.ls_extinction_expression ? _refine.ls_extinction_method ? _refine.ls_goodness_of_fit_all ? _refine.ls_goodness_of_fit_all_esd ? _refine.ls_goodness_of_fit_obs ? _refine.ls_goodness_of_fit_obs_esd ? _refine.ls_hydrogen_treatment ? _refine.ls_matrix_type ? _refine.ls_number_constraints ? _refine.ls_number_parameters ? _refine.ls_number_reflns_all ? _refine.ls_number_reflns_obs 14990 _refine.ls_number_reflns_R_free 804 _refine.ls_number_reflns_R_work ? _refine.ls_number_restraints ? _refine.ls_percent_reflns_obs 97.77 _refine.ls_percent_reflns_R_free 5.1 _refine.ls_R_factor_all ? _refine.ls_R_factor_obs 0.19353 _refine.ls_R_factor_R_free 0.27393 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_R_factor_R_work 0.18945 _refine.ls_R_Fsqd_factor_obs ? _refine.ls_R_I_factor_obs ? _refine.ls_redundancy_reflns_all ? _refine.ls_redundancy_reflns_obs ? _refine.ls_restrained_S_all ? _refine.ls_restrained_S_obs ? _refine.ls_shift_over_esd_max ? _refine.ls_shift_over_esd_mean ? _refine.ls_structure_factor_coef ? _refine.ls_weighting_details ? _refine.ls_weighting_scheme ? _refine.ls_wR_factor_all ? _refine.ls_wR_factor_obs ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.occupancy_max ? _refine.occupancy_min ? _refine.solvent_model_details MASK _refine.solvent_model_param_bsol ? _refine.solvent_model_param_ksol ? _refine.ls_R_factor_gt ? _refine.ls_goodness_of_fit_gt ? _refine.ls_goodness_of_fit_ref ? _refine.ls_shift_over_su_max ? _refine.ls_shift_over_su_max_lt ? _refine.ls_shift_over_su_mean ? _refine.ls_shift_over_su_mean_lt ? _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F ? _refine.pdbx_ls_sigma_Fsqd ? _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.pdbx_method_to_determine_struct ? _refine.pdbx_starting_model ? _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_overall_ESU_R ? _refine.pdbx_overall_ESU_R_Free 0.483 _refine.pdbx_solvent_vdw_probe_radii 1.20 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_real_space_R ? _refine.pdbx_density_correlation ? _refine.pdbx_pd_number_of_powder_patterns ? _refine.pdbx_pd_number_of_points ? _refine.pdbx_pd_meas_number_of_points ? _refine.pdbx_pd_proc_ls_prof_R_factor ? _refine.pdbx_pd_proc_ls_prof_wR_factor ? _refine.pdbx_pd_Marquardt_correlation_coeff ? _refine.pdbx_pd_Fsqrd_R_factor ? _refine.pdbx_pd_ls_matrix_band_width ? _refine.pdbx_overall_phase_error ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_diffrn_id 1 _refine.overall_SU_B 20.473 _refine.overall_SU_ML 0.355 _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_average_fsc_overall ? _refine.pdbx_average_fsc_work ? _refine.pdbx_average_fsc_free ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id 1 _refine_hist.pdbx_number_atoms_protein 4656 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 42 _refine_hist.number_atoms_solvent 0 _refine_hist.number_atoms_total 4698 _refine_hist.d_res_high 3.10 _refine_hist.d_res_low 47.4 # loop_ _refine_ls_restr.pdbx_refine_id _refine_ls_restr.criterion _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.number _refine_ls_restr.rejects _refine_ls_restr.type _refine_ls_restr.weight _refine_ls_restr.pdbx_restraint_function 'X-RAY DIFFRACTION' ? 0.013 0.019 4742 ? r_bond_refined_d ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_bond_other_d ? ? 'X-RAY DIFFRACTION' ? 1.826 1.947 6425 ? r_angle_refined_deg ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_angle_other_deg ? ? 'X-RAY DIFFRACTION' ? 7.613 5.000 574 ? r_dihedral_angle_1_deg ? ? 'X-RAY DIFFRACTION' ? 37.895 23.824 204 ? r_dihedral_angle_2_deg ? ? 'X-RAY DIFFRACTION' ? 20.365 15.000 777 ? r_dihedral_angle_3_deg ? ? 'X-RAY DIFFRACTION' ? 20.284 15.000 23 ? r_dihedral_angle_4_deg ? ? 'X-RAY DIFFRACTION' ? 0.113 0.200 716 ? r_chiral_restr ? ? 'X-RAY DIFFRACTION' ? 0.006 0.021 3531 ? r_gen_planes_refined ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_gen_planes_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_nbd_refined ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_nbd_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_nbtor_refined ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_nbtor_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_xyhbond_nbd_refined ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_xyhbond_nbd_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_metal_ion_refined ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_metal_ion_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_symmetry_vdw_refined ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_symmetry_vdw_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_symmetry_hbond_refined ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_symmetry_hbond_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_symmetry_metal_ion_refined ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_symmetry_metal_ion_other ? ? 'X-RAY DIFFRACTION' ? 5.453 7.490 2327 ? r_mcbond_it ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_mcbond_other ? ? 'X-RAY DIFFRACTION' ? 8.397 11.202 2888 ? r_mcangle_it ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_mcangle_other ? ? 'X-RAY DIFFRACTION' ? 6.541 7.971 2411 ? r_scbond_it ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_scbond_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_scangle_it ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_scangle_other ? ? 'X-RAY DIFFRACTION' ? 13.415 63.305 6897 ? r_long_range_B_refined ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_long_range_B_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_rigid_bond_restr ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_sphericity_free ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_sphericity_bonded ? ? # _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_ls_shell.d_res_high 3.100 _refine_ls_shell.d_res_low 3.181 _refine_ls_shell.number_reflns_all ? _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.number_reflns_R_free 59 _refine_ls_shell.number_reflns_R_work 1095 _refine_ls_shell.percent_reflns_obs 99.06 _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.R_factor_all ? _refine_ls_shell.R_factor_obs ? _refine_ls_shell.R_factor_R_free 0.352 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.R_factor_R_work 0.254 _refine_ls_shell.redundancy_reflns_all ? _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.wR_factor_all ? _refine_ls_shell.wR_factor_obs ? _refine_ls_shell.wR_factor_R_free ? _refine_ls_shell.wR_factor_R_work ? _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.pdbx_phase_error ? _refine_ls_shell.pdbx_fsc_work ? _refine_ls_shell.pdbx_fsc_free ? # _struct.entry_id 5EOD _struct.title 'Human Plasma Coagulation FXI with peptide LP2' _struct.pdbx_descriptor 'Coagulation factor XI (E.C.3.4.21.27), LP2' _struct.pdbx_model_details ? _struct.pdbx_formula_weight ? _struct.pdbx_formula_weight_method ? _struct.pdbx_model_type_details ? _struct.pdbx_CASP_flag ? # _struct_keywords.entry_id 5EOD _struct_keywords.text 'Human, plasma, Coagulation Factor XI, complex, hydrolase' _struct_keywords.pdbx_keywords HYDROLASE # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 3 ? D N N 3 ? E N N 3 ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 AA1 SER A 23 ? HIS A 34 ? SER A 24 HIS A 35 1 ? 12 HELX_P HELX_P2 AA2 ASP A 50 ? TRP A 54 ? ASP A 51 TRP A 55 5 ? 5 HELX_P HELX_P3 AA3 PHE A 81 ? CYS A 84 ? PHE A 82 CYS A 85 5 ? 4 HELX_P HELX_P4 AA4 SER A 113 ? ASP A 124 ? SER A 114 ASP A 125 1 ? 12 HELX_P HELX_P5 AA5 LEU A 171 ? ALA A 175 ? LEU A 172 ALA A 176 5 ? 5 HELX_P HELX_P6 AA6 ASP A 203 ? HIS A 214 ? ASP A 204 HIS A 215 1 ? 12 HELX_P HELX_P7 AA7 LYS A 229 ? ARG A 233 ? LYS A 230 ARG A 234 5 ? 5 HELX_P HELX_P8 AA8 LEU A 261 ? ARG A 265 ? LEU A 262 ARG A 266 5 ? 5 HELX_P HELX_P9 AA9 SER A 294 ? ASN A 304 ? SER A 295 ASN A 305 1 ? 11 HELX_P HELX_P10 AB1 LEU A 354 ? ASP A 358 ? LEU A 355 ASP A 359 5 ? 5 HELX_P HELX_P11 AB2 ASN A 359 ? THR A 363 ? ASN A 360 THR A 364 5 ? 5 HELX_P HELX_P12 AB3 ALA A 411 ? TYR A 415 ? ALA A 412 TYR A 416 5 ? 5 HELX_P HELX_P13 AB4 SER A 419 ? LYS A 421 ? SER A 420 LYS A 422 5 ? 3 HELX_P HELX_P14 AB5 ASN A 431 ? ILE A 435 ? ASN A 432 ILE A 436 5 ? 5 HELX_P HELX_P15 AB6 SER A 484 ? VAL A 490 ? SER A 485 VAL A 491 5 ? 7 HELX_P HELX_P16 AB7 THR A 522 ? TYR A 530 ? THR A 523 TYR A 531 1 ? 9 HELX_P HELX_P17 AB8 TYR A 595 ? LYS A 602 ? TYR A 596 LYS A 603 1 ? 8 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 1 SG ? ? ? 1_555 A CYS 84 SG ? ? A CYS 2 A CYS 85 1_555 ? ? ? ? ? ? ? 2.063 ? disulf2 disulf ? ? A CYS 27 SG ? ? ? 1_555 A CYS 57 SG ? ? A CYS 28 A CYS 58 1_555 ? ? ? ? ? ? ? 2.021 ? disulf3 disulf ? ? A CYS 31 SG ? ? ? 1_555 A CYS 37 SG ? ? A CYS 32 A CYS 38 1_555 ? ? ? ? ? ? ? 2.123 ? disulf4 disulf ? ? A CYS 91 SG ? ? ? 1_555 A CYS 174 SG ? ? A CYS 92 A CYS 175 1_555 ? ? ? ? ? ? ? 2.039 ? disulf5 disulf ? ? A CYS 117 SG ? ? ? 1_555 A CYS 146 SG ? ? A CYS 118 A CYS 147 1_555 ? ? ? ? ? ? ? 2.071 ? disulf6 disulf ? ? A CYS 121 SG ? ? ? 1_555 A CYS 127 SG ? ? A CYS 122 A CYS 128 1_555 ? ? ? ? ? ? ? 2.100 ? disulf7 disulf ? ? A CYS 181 SG ? ? ? 1_555 A CYS 264 SG ? ? A CYS 182 A CYS 265 1_555 ? ? ? ? ? ? ? 2.032 ? disulf8 disulf ? ? A CYS 207 SG ? ? ? 1_555 A CYS 236 SG ? ? A CYS 208 A CYS 237 1_555 ? ? ? ? ? ? ? 2.044 ? disulf9 disulf ? ? A CYS 211 SG ? ? ? 1_555 A CYS 217 SG ? ? A CYS 212 A CYS 218 1_555 ? ? ? ? ? ? ? 2.103 ? disulf10 disulf ? ? A CYS 272 SG ? ? ? 1_555 A CYS 355 SG ? ? A CYS 273 A CYS 356 1_555 ? ? ? ? ? ? ? 2.059 ? disulf11 disulf ? ? A CYS 298 SG ? ? ? 1_555 A CYS 327 SG ? ? A CYS 299 A CYS 328 1_555 ? ? ? ? ? ? ? 2.063 ? disulf12 disulf ? ? A CYS 302 SG ? ? ? 1_555 A CYS 308 SG ? ? A CYS 303 A CYS 309 1_555 ? ? ? ? ? ? ? 2.103 ? disulf13 disulf ? ? A CYS 361 SG ? ? ? 1_555 A CYS 481 SG ? ? A CYS 362 A CYS 482 1_555 ? ? ? ? ? ? ? 2.063 ? disulf14 disulf ? ? A CYS 397 SG ? ? ? 1_555 A CYS 413 SG ? ? A CYS 398 A CYS 414 1_555 ? ? ? ? ? ? ? 2.053 ? disulf15 disulf ? ? A CYS 495 SG ? ? ? 1_555 A CYS 562 SG ? ? A CYS 496 A CYS 563 1_555 ? ? ? ? ? ? ? 2.085 ? disulf16 disulf ? ? A CYS 526 SG ? ? ? 1_555 A CYS 541 SG ? ? A CYS 527 A CYS 542 1_555 ? ? ? ? ? ? ? 2.032 ? covale1 covale one ? A ASN 71 ND2 ? ? ? 1_555 C NAG . C1 ? ? A ASN 72 A NAG 901 1_555 ? ? ? ? ? ? ? 1.474 ? covale2 covale one ? A ASN 107 ND2 ? ? ? 1_555 D NAG . C1 ? ? A ASN 108 A NAG 902 1_555 ? ? ? ? ? ? ? 1.482 ? covale3 covale one ? A LYS 252 C ? ? ? 1_555 A SER 253 CA ? ? A LYS 253 A SER 254 1_555 ? ? ? ? ? ? ? 1.533 ? covale4 covale one ? A ILE 365 O ? ? ? 1_555 A LYS 366 N ? ? A ILE 366 A LYS 367 1_555 ? ? ? ? ? ? ? 1.423 ? covale5 covale none ? A ARG 368 NH2 ? ? ? 1_555 A GLY 378 CA ? ? A ARG 369 A GLY 379 1_555 ? ? ? ? ? ? ? 1.387 ? covale6 covale one ? A ASN 431 ND2 ? ? ? 1_555 E NAG . C1 ? ? A ASN 432 A NAG 903 1_555 ? ? ? ? ? ? ? 1.449 ? covale7 covale one ? A GLU 578 CA ? ? ? 1_555 A GLY 579 N ? ? A GLU 579 A GLY 580 1_555 ? ? ? ? ? ? ? 1.346 ? covale8 covale one ? A GLU 578 C ? ? ? 1_555 A GLY 579 CA ? ? A GLU 579 A GLY 580 1_555 ? ? ? ? ? ? ? 1.397 ? covale9 covale one ? A GLU 578 O ? ? ? 1_555 A GLY 579 N ? ? A GLU 579 A GLY 580 1_555 ? ? ? ? ? ? ? 1.335 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 SER 77 A . ? SER 78 A GLY 78 A ? GLY 79 A 1 -4.93 2 SER 390 A . ? SER 391 A PRO 391 A ? PRO 392 A 1 0.44 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details AA1 ? 2 ? AA2 ? 4 ? AA3 ? 5 ? AA4 ? 2 ? AA5 ? 4 ? AA6 ? 5 ? AA7 ? 6 ? AA8 ? 7 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense AA1 1 2 ? anti-parallel AA2 1 2 ? anti-parallel AA2 2 3 ? anti-parallel AA2 3 4 ? anti-parallel AA3 1 2 ? anti-parallel AA3 2 3 ? anti-parallel AA3 3 4 ? anti-parallel AA3 4 5 ? anti-parallel AA4 1 2 ? anti-parallel AA5 1 2 ? anti-parallel AA5 2 3 ? anti-parallel AA5 3 4 ? anti-parallel AA6 1 2 ? anti-parallel AA6 2 3 ? anti-parallel AA6 3 4 ? anti-parallel AA6 4 5 ? anti-parallel AA7 1 2 ? anti-parallel AA7 2 3 ? anti-parallel AA7 3 4 ? anti-parallel AA7 4 5 ? anti-parallel AA7 5 6 ? anti-parallel AA8 1 2 ? anti-parallel AA8 2 3 ? anti-parallel AA8 3 4 ? anti-parallel AA8 4 5 ? anti-parallel AA8 5 6 ? anti-parallel AA8 6 7 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id AA1 1 THR A 9 ? PHE A 11 ? THR A 10 PHE A 12 AA1 2 ARG A 69 ? ASN A 71 ? ARG A 70 ASN A 72 AA2 1 ASP A 15 ? PHE A 20 ? ASP A 16 PHE A 21 AA2 2 THR A 56 ? LYS A 60 ? THR A 57 LYS A 61 AA2 3 LEU A 39 ? THR A 43 ? LEU A 40 THR A 44 AA2 4 ALA A 75 ? TYR A 79 ? ALA A 76 TYR A 80 AA3 1 ILE A 95 ? LYS A 102 ? ILE A 96 LYS A 103 AA3 2 ARG A 158 ? PHE A 169 ? ARG A 159 PHE A 170 AA3 3 PHE A 129 ? ALA A 133 ? PHE A 130 ALA A 134 AA3 4 ILE A 145 ? HIS A 150 ? ILE A 146 HIS A 151 AA3 5 ILE A 104 ? VAL A 110 ? ILE A 105 VAL A 111 AA4 1 THR A 189 ? PHE A 191 ? THR A 190 PHE A 192 AA4 2 ARG A 249 ? LYS A 251 ? ARG A 250 LYS A 252 AA5 1 SER A 194 ? MET A 200 ? SER A 195 MET A 201 AA5 2 LEU A 235 ? THR A 240 ? LEU A 236 THR A 241 AA5 3 PHE A 219 ? PHE A 223 ? PHE A 220 PHE A 224 AA5 4 ALA A 255 ? PHE A 259 ? ALA A 256 PHE A 260 AA6 1 TYR A 277 ? LEU A 283 ? TYR A 278 LEU A 284 AA6 2 LYS A 339 ? TYR A 350 ? LYS A 340 TYR A 351 AA6 3 PHE A 310 ? THR A 314 ? PHE A 311 THR A 315 AA6 4 GLY A 325 ? LEU A 331 ? GLY A 326 LEU A 332 AA6 5 GLU A 285 ? ALA A 292 ? GLU A 286 ALA A 293 AA7 1 LEU A 423 ? TYR A 426 ? LEU A 424 TYR A 427 AA7 2 GLN A 383 ? THR A 388 ? GLN A 384 THR A 389 AA7 3 ARG A 394 ? ILE A 401 ? ARG A 395 ILE A 402 AA7 4 TRP A 406 ? THR A 409 ? TRP A 407 THR A 410 AA7 5 ALA A 463 ? LEU A 467 ? ALA A 464 LEU A 468 AA7 6 VAL A 444 ? ILE A 449 ? VAL A 445 ILE A 450 AA8 1 GLN A 514 ? ILE A 518 ? GLN A 515 ILE A 519 AA8 2 CYS A 495 ? GLY A 499 ? CYS A 496 GLY A 500 AA8 3 PRO A 559 ? HIS A 564 ? PRO A 560 HIS A 565 AA8 4 VAL A 567 ? SER A 575 ? VAL A 568 SER A 576 AA8 5 GLY A 587 ? ASN A 591 ? GLY A 588 ASN A 592 AA8 6 MET A 539 ? ALA A 542 ? MET A 540 ALA A 543 AA8 7 LEU A 520 ? VAL A 521 ? LEU A 521 VAL A 522 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id AA1 1 2 N CYS A 10 ? N CYS A 11 O VAL A 70 ? O VAL A 71 AA2 1 2 N VAL A 19 ? N VAL A 20 O CYS A 57 ? O CYS A 58 AA2 2 3 O THR A 56 ? O THR A 57 N THR A 43 ? N THR A 44 AA2 3 4 N PHE A 42 ? N PHE A 43 O ILE A 76 ? O ILE A 77 AA3 1 2 N LYS A 102 ? N LYS A 103 O ARG A 158 ? O ARG A 159 AA3 2 3 O VAL A 166 ? O VAL A 167 N TYR A 132 ? N TYR A 133 AA3 3 4 N ALA A 133 ? N ALA A 134 O ILE A 145 ? O ILE A 146 AA3 4 5 O CYS A 146 ? O CYS A 147 N SER A 109 ? N SER A 110 AA4 1 2 N VAL A 190 ? N VAL A 191 O ILE A 250 ? O ILE A 251 AA5 1 2 N ASP A 197 ? N ASP A 198 O LEU A 238 ? O LEU A 239 AA5 2 3 O LYS A 239 ? O LYS A 240 N PHE A 219 ? N PHE A 220 AA5 3 4 N PHE A 222 ? N PHE A 223 O LEU A 256 ? O LEU A 257 AA6 1 2 N ASP A 281 ? N ASP A 282 O LEU A 341 ? O LEU A 342 AA6 2 3 O ILE A 347 ? O ILE A 348 N TYR A 313 ? N TYR A 314 AA6 3 4 N THR A 312 ? N THR A 313 O TYR A 328 ? O TYR A 329 AA6 4 5 O LEU A 329 ? O LEU A 330 N LEU A 287 ? N LEU A 288 AA7 1 2 O ARG A 424 ? O ARG A 425 N HIS A 387 ? N HIS A 388 AA7 2 3 N LEU A 386 ? N LEU A 387 O LEU A 396 ? O LEU A 397 AA7 3 4 N SER A 400 ? N SER A 401 O LEU A 408 ? O LEU A 409 AA7 4 5 N THR A 409 ? N THR A 410 O ALA A 463 ? O ALA A 464 AA7 5 6 O LEU A 464 ? O LEU A 465 N ILE A 448 ? N ILE A 449 AA8 1 2 O GLN A 514 ? O GLN A 515 N GLY A 499 ? N GLY A 500 AA8 2 3 N TRP A 496 ? N TRP A 497 O SER A 561 ? O SER A 562 AA8 3 4 N LEU A 560 ? N LEU A 561 O GLY A 572 ? O GLY A 573 AA8 4 5 N ILE A 573 ? N ILE A 574 O THR A 590 ? O THR A 591 AA8 5 6 O GLY A 587 ? O GLY A 588 N ALA A 542 ? N ALA A 543 AA8 6 7 O CYS A 541 ? O CYS A 542 N VAL A 521 ? N VAL A 522 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software A NAG 901 ? 1 'binding site for Mono-Saccharide NAG A 901 bound to ASN A 72' AC2 Software A NAG 902 ? 2 'binding site for Mono-Saccharide NAG A 902 bound to ASN A 108' AC3 Software A NAG 903 ? 2 'binding site for Mono-Saccharide NAG A 903 bound to ASN A 432' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 1 ASN A 71 ? ASN A 72 . ? 1_555 ? 2 AC2 2 ASN A 107 ? ASN A 108 . ? 1_555 ? 3 AC2 2 ASP A 124 ? ASP A 125 . ? 1_555 ? 4 AC3 2 ASN A 431 ? ASN A 432 . ? 1_555 ? 5 AC3 2 ASN A 511 ? ASN A 512 . ? 1_555 ? # _atom_sites.entry_id 5EOD _atom_sites.fract_transf_matrix[1][1] 0.012336 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] -0.000000 _atom_sites.fract_transf_matrix[2][2] 0.012336 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] -0.000000 _atom_sites.fract_transf_matrix[3][3] 0.003951 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . CYS A 1 1 ? -44.379 22.233 -25.343 1.00 96.98 ? 2 CYS A N 1 ATOM 2 C CA . CYS A 1 1 ? -43.576 22.958 -24.319 1.00 97.65 ? 2 CYS A CA 1 ATOM 3 C C . CYS A 1 1 ? -42.428 23.706 -24.986 1.00 93.92 ? 2 CYS A C 1 ATOM 4 O O . CYS A 1 1 ? -41.937 23.277 -26.029 1.00 91.79 ? 2 CYS A O 1 ATOM 5 C CB . CYS A 1 1 ? -43.039 21.995 -23.252 1.00 106.49 ? 2 CYS A CB 1 ATOM 6 S SG . CYS A 1 1 ? -41.651 20.923 -23.736 1.00 110.00 ? 2 CYS A SG 1 ATOM 7 N N . VAL A 1 2 ? -41.994 24.799 -24.353 1.00 86.13 ? 3 VAL A N 1 ATOM 8 C CA . VAL A 1 2 ? -41.073 25.780 -24.947 1.00 80.84 ? 3 VAL A CA 1 ATOM 9 C C . VAL A 1 2 ? -39.668 25.686 -24.297 1.00 91.79 ? 3 VAL A C 1 ATOM 10 O O . VAL A 1 2 ? -39.345 26.408 -23.324 1.00 98.07 ? 3 VAL A O 1 ATOM 11 C CB . VAL A 1 2 ? -41.676 27.226 -24.901 1.00 76.10 ? 3 VAL A CB 1 ATOM 12 C CG1 . VAL A 1 2 ? -40.805 28.253 -25.627 1.00 74.87 ? 3 VAL A CG1 1 ATOM 13 C CG2 . VAL A 1 2 ? -43.083 27.256 -25.487 1.00 76.98 ? 3 VAL A CG2 1 ATOM 14 N N . THR A 1 3 ? -38.833 24.807 -24.860 1.00 86.50 ? 4 THR A N 1 ATOM 15 C CA . THR A 1 3 ? -37.525 24.492 -24.281 1.00 78.02 ? 4 THR A CA 1 ATOM 16 C C . THR A 1 3 ? -36.488 25.580 -24.521 1.00 80.45 ? 4 THR A C 1 ATOM 17 O O . THR A 1 3 ? -35.704 25.894 -23.625 1.00 96.59 ? 4 THR A O 1 ATOM 18 C CB . THR A 1 3 ? -36.962 23.167 -24.794 1.00 74.38 ? 4 THR A CB 1 ATOM 19 O OG1 . THR A 1 3 ? -36.525 23.341 -26.150 1.00 80.34 ? 4 THR A OG1 1 ATOM 20 C CG2 . THR A 1 3 ? -38.002 22.033 -24.673 1.00 69.90 ? 4 THR A CG2 1 ATOM 21 N N . GLN A 1 4 ? -36.477 26.131 -25.731 1.00 77.15 ? 5 GLN A N 1 ATOM 22 C CA . GLN A 1 4 ? -35.642 27.294 -26.085 1.00 81.13 ? 5 GLN A CA 1 ATOM 23 C C . GLN A 1 4 ? -35.889 28.522 -25.191 1.00 75.93 ? 5 GLN A C 1 ATOM 24 O O . GLN A 1 4 ? -36.934 28.647 -24.527 1.00 81.16 ? 5 GLN A O 1 ATOM 25 C CB . GLN A 1 4 ? -35.837 27.680 -27.569 1.00 89.95 ? 5 GLN A CB 1 ATOM 26 C CG . GLN A 1 4 ? -37.220 28.239 -27.927 1.00 92.72 ? 5 GLN A CG 1 ATOM 27 C CD . GLN A 1 4 ? -38.294 27.163 -28.120 1.00 99.51 ? 5 GLN A CD 1 ATOM 28 O OE1 . GLN A 1 4 ? -38.296 26.100 -27.469 1.00 93.18 ? 5 GLN A OE1 1 ATOM 29 N NE2 . GLN A 1 4 ? -39.226 27.445 -29.024 1.00 106.72 ? 5 GLN A NE2 1 ATOM 30 N N . LEU A 1 5 ? -34.916 29.422 -25.206 1.00 65.62 ? 6 LEU A N 1 ATOM 31 C CA . LEU A 1 5 ? -34.941 30.635 -24.401 1.00 62.04 ? 6 LEU A CA 1 ATOM 32 C C . LEU A 1 5 ? -35.300 31.868 -25.270 1.00 63.35 ? 6 LEU A C 1 ATOM 33 O O . LEU A 1 5 ? -35.737 31.703 -26.408 1.00 70.72 ? 6 LEU A O 1 ATOM 34 C CB . LEU A 1 5 ? -33.612 30.785 -23.633 1.00 57.00 ? 6 LEU A CB 1 ATOM 35 C CG . LEU A 1 5 ? -32.808 29.546 -23.173 1.00 56.82 ? 6 LEU A CG 1 ATOM 36 C CD1 . LEU A 1 5 ? -31.426 29.945 -22.652 1.00 53.91 ? 6 LEU A CD1 1 ATOM 37 C CD2 . LEU A 1 5 ? -33.532 28.660 -22.160 1.00 55.51 ? 6 LEU A CD2 1 ATOM 38 N N . LEU A 1 6 ? -35.130 33.085 -24.743 1.00 63.87 ? 7 LEU A N 1 ATOM 39 C CA . LEU A 1 6 ? -35.670 34.308 -25.363 1.00 67.34 ? 7 LEU A CA 1 ATOM 40 C C . LEU A 1 6 ? -34.714 35.558 -25.327 1.00 77.68 ? 7 LEU A C 1 ATOM 41 O O . LEU A 1 6 ? -34.597 36.239 -24.289 1.00 83.87 ? 7 LEU A O 1 ATOM 42 C CB . LEU A 1 6 ? -37.060 34.625 -24.774 1.00 60.79 ? 7 LEU A CB 1 ATOM 43 C CG . LEU A 1 6 ? -38.126 33.581 -24.360 1.00 61.79 ? 7 LEU A CG 1 ATOM 44 C CD1 . LEU A 1 6 ? -39.263 34.262 -23.614 1.00 62.16 ? 7 LEU A CD1 1 ATOM 45 C CD2 . LEU A 1 6 ? -38.703 32.731 -25.478 1.00 58.82 ? 7 LEU A CD2 1 ATOM 46 N N . LYS A 1 7 ? -34.080 35.852 -26.480 1.00 73.94 ? 8 LYS A N 1 ATOM 47 C CA . LYS A 1 7 ? -32.972 36.811 -26.617 1.00 53.59 ? 8 LYS A CA 1 ATOM 48 C C . LYS A 1 7 ? -33.623 37.973 -25.601 0.00 86.38 ? 8 LYS A C 1 ATOM 49 O O . LYS A 1 7 ? -34.260 38.474 -26.522 0.00 87.74 ? 8 LYS A O 1 ATOM 50 C CB . LYS A 1 7 ? -32.236 36.261 -26.778 0.00 88.25 ? 8 LYS A CB 1 ATOM 51 C CG . LYS A 1 7 ? -30.960 37.077 -26.657 0.00 90.74 ? 8 LYS A CG 1 ATOM 52 C CD . LYS A 1 7 ? -30.010 36.791 -27.810 0.00 92.54 ? 8 LYS A CD 1 ATOM 53 C CE . LYS A 1 7 ? -28.736 37.611 -27.691 0.00 95.22 ? 8 LYS A CE 1 ATOM 54 N NZ . LYS A 1 7 ? -27.794 37.343 -28.815 0.00 96.64 ? 8 LYS A NZ 1 ATOM 55 N N . ASP A 1 8 ? -33.672 38.594 -25.523 1.00 71.68 ? 9 ASP A N 1 ATOM 56 C CA . ASP A 1 8 ? -33.624 39.817 -24.738 1.00 93.62 ? 9 ASP A CA 1 ATOM 57 C C . ASP A 1 8 ? -34.986 40.092 -24.133 1.00 91.19 ? 9 ASP A C 1 ATOM 58 O O . ASP A 1 8 ? -35.558 41.177 -24.285 1.00 94.73 ? 9 ASP A O 1 ATOM 59 C CB . ASP A 1 8 ? -33.149 40.997 -25.593 1.00 103.10 ? 9 ASP A CB 1 ATOM 60 C CG . ASP A 1 8 ? -31.724 41.426 -25.281 1.00 107.13 ? 9 ASP A CG 1 ATOM 61 O OD1 . ASP A 1 8 ? -31.088 40.882 -24.353 1.00 111.92 ? 9 ASP A OD1 1 ATOM 62 O OD2 . ASP A 1 8 ? -31.244 42.350 -25.968 1.00 113.47 ? 9 ASP A OD2 1 ATOM 63 N N . THR A 1 9 ? -35.493 39.095 -23.425 1.00 93.78 ? 10 THR A N 1 ATOM 64 C CA . THR A 1 9 ? -36.864 39.117 -22.953 1.00 86.02 ? 10 THR A CA 1 ATOM 65 C C . THR A 1 9 ? -36.924 38.917 -21.461 1.00 84.15 ? 10 THR A C 1 ATOM 66 O O . THR A 1 9 ? -36.186 38.102 -20.885 1.00 78.84 ? 10 THR A O 1 ATOM 67 C CB . THR A 1 9 ? -37.697 38.035 -23.643 1.00 85.30 ? 10 THR A CB 1 ATOM 68 O OG1 . THR A 1 9 ? -37.159 37.798 -24.945 1.00 88.48 ? 10 THR A OG1 1 ATOM 69 C CG2 . THR A 1 9 ? -39.140 38.471 -23.769 1.00 89.36 ? 10 THR A CG2 1 ATOM 70 N N . CYS A 1 10 ? -37.830 39.679 -20.861 1.00 83.31 ? 11 CYS A N 1 ATOM 71 C CA . CYS A 1 10 ? -38.089 39.674 -19.438 1.00 81.77 ? 11 CYS A CA 1 ATOM 72 C C . CYS A 1 10 ? -39.553 39.318 -19.216 1.00 77.44 ? 11 CYS A C 1 ATOM 73 O O . CYS A 1 10 ? -40.403 39.754 -19.987 1.00 84.42 ? 11 CYS A O 1 ATOM 74 C CB . CYS A 1 10 ? -37.783 41.061 -18.888 1.00 76.64 ? 11 CYS A CB 1 ATOM 75 S SG . CYS A 1 10 ? -38.511 41.412 -17.282 1.00 104.25 ? 11 CYS A SG 1 ATOM 76 N N . PHE A 1 11 ? -39.846 38.518 -18.186 1.00 73.22 ? 12 PHE A N 1 ATOM 77 C CA . PHE A 1 11 ? -41.245 38.286 -17.752 1.00 72.83 ? 12 PHE A CA 1 ATOM 78 C C . PHE A 1 11 ? -41.614 39.220 -16.598 1.00 72.17 ? 12 PHE A C 1 ATOM 79 O O . PHE A 1 11 ? -40.864 39.339 -15.624 1.00 73.52 ? 12 PHE A O 1 ATOM 80 C CB . PHE A 1 11 ? -41.488 36.840 -17.324 1.00 65.43 ? 12 PHE A CB 1 ATOM 81 C CG . PHE A 1 11 ? -41.523 35.849 -18.452 1.00 66.94 ? 12 PHE A CG 1 ATOM 82 C CD1 . PHE A 1 11 ? -42.597 35.806 -19.336 1.00 70.56 ? 12 PHE A CD1 1 ATOM 83 C CD2 . PHE A 1 11 ? -40.508 34.898 -18.595 1.00 67.64 ? 12 PHE A CD2 1 ATOM 84 C CE1 . PHE A 1 11 ? -42.638 34.855 -20.362 1.00 70.85 ? 12 PHE A CE1 1 ATOM 85 C CE2 . PHE A 1 11 ? -40.547 33.948 -19.615 1.00 64.20 ? 12 PHE A CE2 1 ATOM 86 C CZ . PHE A 1 11 ? -41.613 33.923 -20.497 1.00 63.02 ? 12 PHE A CZ 1 ATOM 87 N N . GLU A 1 12 ? -42.762 39.880 -16.696 1.00 68.70 ? 13 GLU A N 1 ATOM 88 C CA . GLU A 1 12 ? -43.121 40.854 -15.672 1.00 73.10 ? 13 GLU A CA 1 ATOM 89 C C . GLU A 1 12 ? -43.891 40.238 -14.509 1.00 70.44 ? 13 GLU A C 1 ATOM 90 O O . GLU A 1 12 ? -45.003 39.744 -14.694 1.00 70.83 ? 13 GLU A O 1 ATOM 91 C CB . GLU A 1 12 ? -43.886 42.036 -16.287 1.00 81.92 ? 13 GLU A CB 1 ATOM 92 C CG . GLU A 1 12 ? -44.272 43.163 -15.311 1.00 81.93 ? 13 GLU A CG 1 ATOM 93 C CD . GLU A 1 12 ? -43.106 44.038 -14.846 1.00 79.82 ? 13 GLU A CD 1 ATOM 94 O OE1 . GLU A 1 12 ? -42.103 44.209 -15.593 1.00 83.77 ? 13 GLU A OE1 1 ATOM 95 O OE2 . GLU A 1 12 ? -43.206 44.562 -13.716 1.00 71.21 ? 13 GLU A OE2 1 ATOM 96 N N . GLY A 1 13 ? -43.291 40.284 -13.319 1.00 72.41 ? 14 GLY A N 1 ATOM 97 C CA . GLY A 1 13 ? -43.910 39.753 -12.087 1.00 75.73 ? 14 GLY A CA 1 ATOM 98 C C . GLY A 1 13 ? -43.793 38.239 -11.935 1.00 75.85 ? 14 GLY A C 1 ATOM 99 O O . GLY A 1 13 ? -43.055 37.594 -12.670 1.00 85.42 ? 14 GLY A O 1 ATOM 100 N N . GLY A 1 14 ? -44.504 37.670 -10.967 1.00 71.25 ? 15 GLY A N 1 ATOM 101 C CA . GLY A 1 14 ? -44.448 36.233 -10.712 1.00 65.87 ? 15 GLY A CA 1 ATOM 102 C C . GLY A 1 14 ? -43.486 35.969 -9.588 1.00 64.97 ? 15 GLY A C 1 ATOM 103 O O . GLY A 1 14 ? -43.640 35.010 -8.851 1.00 68.81 ? 15 GLY A O 1 ATOM 104 N N . ASP A 1 15 ? -42.518 36.865 -9.447 1.00 66.35 ? 16 ASP A N 1 ATOM 105 C CA . ASP A 1 15 ? -41.445 36.746 -8.486 1.00 69.59 ? 16 ASP A CA 1 ATOM 106 C C . ASP A 1 15 ? -41.805 35.896 -7.278 1.00 68.09 ? 16 ASP A C 1 ATOM 107 O O . ASP A 1 15 ? -42.523 36.307 -6.385 1.00 70.71 ? 16 ASP A O 1 ATOM 108 C CB . ASP A 1 15 ? -40.956 38.129 -8.093 1.00 74.22 ? 16 ASP A CB 1 ATOM 109 C CG . ASP A 1 15 ? -40.250 38.814 -9.214 1.00 78.48 ? 16 ASP A CG 1 ATOM 110 O OD1 . ASP A 1 15 ? -40.729 38.751 -10.363 1.00 89.55 ? 16 ASP A OD1 1 ATOM 111 O OD2 . ASP A 1 15 ? -39.199 39.414 -8.954 1.00 92.24 ? 16 ASP A OD2 1 ATOM 112 N N . ILE A 1 16 ? -41.328 34.664 -7.332 1.00 69.04 ? 17 ILE A N 1 ATOM 113 C CA . ILE A 1 16 ? -41.444 33.710 -6.258 1.00 62.59 ? 17 ILE A CA 1 ATOM 114 C C . ILE A 1 16 ? -40.186 33.856 -5.450 1.00 58.28 ? 17 ILE A C 1 ATOM 115 O O . ILE A 1 16 ? -40.263 34.329 -4.345 1.00 72.77 ? 17 ILE A O 1 ATOM 116 C CB . ILE A 1 16 ? -41.738 32.280 -6.799 1.00 64.11 ? 17 ILE A CB 1 ATOM 117 C CG1 . ILE A 1 16 ? -43.252 32.126 -7.094 1.00 77.44 ? 17 ILE A CG1 1 ATOM 118 C CG2 . ILE A 1 16 ? -41.245 31.200 -5.861 1.00 52.16 ? 17 ILE A CG2 1 ATOM 119 C CD1 . ILE A 1 16 ? -44.249 33.072 -6.365 1.00 74.96 ? 17 ILE A CD1 1 ATOM 120 N N . THR A 1 17 ? -39.029 33.524 -6.009 1.00 58.17 ? 18 THR A N 1 ATOM 121 C CA . THR A 1 17 ? -37.747 33.855 -5.355 1.00 59.93 ? 18 THR A CA 1 ATOM 122 C C . THR A 1 17 ? -36.644 34.344 -6.310 1.00 57.22 ? 18 THR A C 1 ATOM 123 O O . THR A 1 17 ? -36.844 34.415 -7.528 1.00 59.42 ? 18 THR A O 1 ATOM 124 C CB . THR A 1 17 ? -37.243 32.743 -4.398 1.00 59.41 ? 18 THR A CB 1 ATOM 125 O OG1 . THR A 1 17 ? -36.321 33.314 -3.472 1.00 65.15 ? 18 THR A OG1 1 ATOM 126 C CG2 . THR A 1 17 ? -36.544 31.602 -5.140 1.00 59.30 ? 18 THR A CG2 1 ATOM 127 N N . THR A 1 18 ? -35.503 34.715 -5.742 1.00 52.05 ? 19 THR A N 1 ATOM 128 C CA . THR A 1 18 ? -34.390 35.192 -6.530 1.00 58.04 ? 19 THR A CA 1 ATOM 129 C C . THR A 1 18 ? -33.151 34.459 -6.086 1.00 59.58 ? 19 THR A C 1 ATOM 130 O O . THR A 1 18 ? -32.878 34.380 -4.893 1.00 65.94 ? 19 THR A O 1 ATOM 131 C CB . THR A 1 18 ? -34.232 36.718 -6.408 1.00 59.67 ? 19 THR A CB 1 ATOM 132 O OG1 . THR A 1 18 ? -35.448 37.334 -6.850 1.00 66.08 ? 19 THR A OG1 1 ATOM 133 C CG2 . THR A 1 18 ? -33.104 37.214 -7.280 1.00 57.60 ? 19 THR A CG2 1 ATOM 134 N N . VAL A 1 19 ? -32.433 33.899 -7.060 1.00 57.63 ? 20 VAL A N 1 ATOM 135 C CA . VAL A 1 19 ? -31.209 33.136 -6.830 1.00 55.12 ? 20 VAL A CA 1 ATOM 136 C C . VAL A 1 19 ? -30.138 33.593 -7.794 1.00 55.62 ? 20 VAL A C 1 ATOM 137 O O . VAL A 1 19 ? -30.421 34.348 -8.737 1.00 55.52 ? 20 VAL A O 1 ATOM 138 C CB . VAL A 1 19 ? -31.440 31.616 -7.000 1.00 54.81 ? 20 VAL A CB 1 ATOM 139 C CG1 . VAL A 1 19 ? -32.143 31.067 -5.778 1.00 60.45 ? 20 VAL A CG1 1 ATOM 140 C CG2 . VAL A 1 19 ? -32.247 31.303 -8.256 1.00 51.38 ? 20 VAL A CG2 1 ATOM 141 N N . PHE A 1 20 ? -28.916 33.120 -7.571 1.00 58.15 ? 21 PHE A N 1 ATOM 142 C CA . PHE A 1 20 ? -27.831 33.393 -8.504 1.00 56.85 ? 21 PHE A CA 1 ATOM 143 C C . PHE A 1 20 ? -27.398 32.168 -9.267 1.00 53.69 ? 21 PHE A C 1 ATOM 144 O O . PHE A 1 20 ? -26.928 31.210 -8.669 1.00 59.24 ? 21 PHE A O 1 ATOM 145 C CB . PHE A 1 20 ? -26.640 34.007 -7.777 1.00 64.36 ? 21 PHE A CB 1 ATOM 146 C CG . PHE A 1 20 ? -26.881 35.405 -7.275 1.00 67.67 ? 21 PHE A CG 1 ATOM 147 C CD1 . PHE A 1 20 ? -27.177 36.449 -8.162 1.00 72.60 ? 21 PHE A CD1 1 ATOM 148 C CD2 . PHE A 1 20 ? -26.789 35.687 -5.922 1.00 64.60 ? 21 PHE A CD2 1 ATOM 149 C CE1 . PHE A 1 20 ? -27.399 37.737 -7.699 1.00 73.72 ? 21 PHE A CE1 1 ATOM 150 C CE2 . PHE A 1 20 ? -26.999 36.974 -5.453 1.00 69.57 ? 21 PHE A CE2 1 ATOM 151 C CZ . PHE A 1 20 ? -27.308 37.999 -6.338 1.00 75.27 ? 21 PHE A CZ 1 ATOM 152 N N . THR A 1 21 ? -27.584 32.187 -10.582 1.00 55.85 ? 22 THR A N 1 ATOM 153 C CA . THR A 1 21 ? -27.084 31.101 -11.453 1.00 61.24 ? 22 THR A CA 1 ATOM 154 C C . THR A 1 21 ? -25.961 31.599 -12.350 1.00 61.71 ? 22 THR A C 1 ATOM 155 O O . THR A 1 21 ? -25.944 32.782 -12.699 1.00 66.37 ? 22 THR A O 1 ATOM 156 C CB . THR A 1 21 ? -28.171 30.409 -12.326 1.00 60.52 ? 22 THR A CB 1 ATOM 157 O OG1 . THR A 1 21 ? -28.832 31.369 -13.150 1.00 56.87 ? 22 THR A OG1 1 ATOM 158 C CG2 . THR A 1 21 ? -29.183 29.700 -11.466 1.00 62.20 ? 22 THR A CG2 1 ATOM 159 N N . PRO A 1 22 ? -25.001 30.708 -12.699 1.00 61.85 ? 23 PRO A N 1 ATOM 160 C CA . PRO A 1 22 ? -23.958 31.045 -13.668 1.00 62.01 ? 23 PRO A CA 1 ATOM 161 C C . PRO A 1 22 ? -24.434 31.256 -15.097 1.00 57.62 ? 23 PRO A C 1 ATOM 162 O O . PRO A 1 22 ? -23.720 31.861 -15.861 1.00 62.04 ? 23 PRO A O 1 ATOM 163 C CB . PRO A 1 22 ? -23.009 29.840 -13.614 1.00 63.81 ? 23 PRO A CB 1 ATOM 164 C CG . PRO A 1 22 ? -23.803 28.743 -13.005 1.00 65.32 ? 23 PRO A CG 1 ATOM 165 C CD . PRO A 1 22 ? -24.670 29.449 -12.007 1.00 65.73 ? 23 PRO A CD 1 ATOM 166 N N . SER A 1 23 ? -25.609 30.760 -15.457 1.00 56.61 ? 24 SER A N 1 ATOM 167 C CA . SER A 1 23 ? -26.135 30.945 -16.801 1.00 53.53 ? 24 SER A CA 1 ATOM 168 C C . SER A 1 23 ? -27.622 30.723 -16.794 1.00 54.15 ? 24 SER A C 1 ATOM 169 O O . SER A 1 23 ? -28.140 30.002 -15.924 1.00 51.46 ? 24 SER A O 1 ATOM 170 C CB . SER A 1 23 ? -25.530 29.916 -17.747 1.00 55.58 ? 24 SER A CB 1 ATOM 171 O OG . SER A 1 23 ? -25.931 28.588 -17.399 1.00 58.16 ? 24 SER A OG 1 ATOM 172 N N . ALA A 1 24 ? -28.272 31.304 -17.804 1.00 51.15 ? 25 ALA A N 1 ATOM 173 C CA . ALA A 1 24 ? -29.671 31.066 -18.110 1.00 56.40 ? 25 ALA A CA 1 ATOM 174 C C . ALA A 1 24 ? -30.038 29.576 -18.242 1.00 59.82 ? 25 ALA A C 1 ATOM 175 O O . ALA A 1 24 ? -31.105 29.150 -17.730 1.00 59.88 ? 25 ALA A O 1 ATOM 176 C CB . ALA A 1 24 ? -30.081 31.821 -19.363 1.00 51.90 ? 25 ALA A CB 1 ATOM 177 N N . LYS A 1 25 ? -29.172 28.790 -18.897 1.00 55.24 ? 26 LYS A N 1 ATOM 178 C CA . LYS A 1 25 ? -29.542 27.416 -19.215 1.00 56.78 ? 26 LYS A CA 1 ATOM 179 C C . LYS A 1 25 ? -29.682 26.611 -17.929 1.00 54.62 ? 26 LYS A C 1 ATOM 180 O O . LYS A 1 25 ? -30.564 25.741 -17.817 1.00 54.34 ? 26 LYS A O 1 ATOM 181 C CB . LYS A 1 25 ? -28.636 26.771 -20.284 1.00 61.48 ? 26 LYS A CB 1 ATOM 182 C CG . LYS A 1 25 ? -27.594 25.765 -19.803 1.00 78.71 ? 26 LYS A CG 1 ATOM 183 C CD . LYS A 1 25 ? -27.478 24.540 -20.722 1.00 84.96 ? 26 LYS A CD 1 ATOM 184 C CE . LYS A 1 25 ? -26.758 23.363 -20.051 1.00 88.30 ? 26 LYS A CE 1 ATOM 185 N NZ . LYS A 1 25 ? -25.267 23.435 -20.167 1.00 93.91 ? 26 LYS A NZ 1 ATOM 186 N N . TYR A 1 26 ? -28.851 26.964 -16.952 1.00 52.37 ? 27 TYR A N 1 ATOM 187 C CA . TYR A 1 26 ? -28.859 26.324 -15.651 1.00 55.72 ? 27 TYR A CA 1 ATOM 188 C C . TYR A 1 26 ? -29.965 26.909 -14.765 1.00 58.24 ? 27 TYR A C 1 ATOM 189 O O . TYR A 1 26 ? -30.563 26.198 -13.955 1.00 56.55 ? 27 TYR A O 1 ATOM 190 C CB . TYR A 1 26 ? -27.488 26.472 -14.986 1.00 56.79 ? 27 TYR A CB 1 ATOM 191 C CG . TYR A 1 26 ? -27.361 25.686 -13.705 1.00 54.99 ? 27 TYR A CG 1 ATOM 192 C CD1 . TYR A 1 26 ? -27.300 24.280 -13.725 1.00 54.93 ? 27 TYR A CD1 1 ATOM 193 C CD2 . TYR A 1 26 ? -27.334 26.341 -12.470 1.00 52.03 ? 27 TYR A CD2 1 ATOM 194 C CE1 . TYR A 1 26 ? -27.214 23.547 -12.549 1.00 53.17 ? 27 TYR A CE1 1 ATOM 195 C CE2 . TYR A 1 26 ? -27.254 25.624 -11.289 1.00 50.66 ? 27 TYR A CE2 1 ATOM 196 C CZ . TYR A 1 26 ? -27.192 24.235 -11.332 1.00 53.82 ? 27 TYR A CZ 1 ATOM 197 O OH . TYR A 1 26 ? -27.104 23.534 -10.153 1.00 56.41 ? 27 TYR A OH 1 ATOM 198 N N . CYS A 1 27 ? -30.220 28.210 -14.920 1.00 60.30 ? 28 CYS A N 1 ATOM 199 C CA . CYS A 1 27 ? -31.350 28.877 -14.297 1.00 52.96 ? 28 CYS A CA 1 ATOM 200 C C . CYS A 1 27 ? -32.598 28.090 -14.674 1.00 54.78 ? 28 CYS A C 1 ATOM 201 O O . CYS A 1 27 ? -33.374 27.719 -13.792 1.00 59.20 ? 28 CYS A O 1 ATOM 202 C CB . CYS A 1 27 ? -31.388 30.333 -14.725 1.00 51.67 ? 28 CYS A CB 1 ATOM 203 S SG . CYS A 1 27 ? -32.788 31.357 -14.223 1.00 65.84 ? 28 CYS A SG 1 ATOM 204 N N . GLN A 1 28 ? -32.737 27.745 -15.955 1.00 51.70 ? 29 GLN A N 1 ATOM 205 C CA . GLN A 1 28 ? -33.821 26.858 -16.423 1.00 52.44 ? 29 GLN A CA 1 ATOM 206 C C . GLN A 1 28 ? -33.916 25.520 -15.653 1.00 50.93 ? 29 GLN A C 1 ATOM 207 O O . GLN A 1 28 ? -34.999 25.012 -15.396 1.00 50.57 ? 29 GLN A O 1 ATOM 208 C CB . GLN A 1 28 ? -33.683 26.598 -17.935 1.00 58.09 ? 29 GLN A CB 1 ATOM 209 C CG . GLN A 1 28 ? -34.968 26.138 -18.627 1.00 62.52 ? 29 GLN A CG 1 ATOM 210 C CD . GLN A 1 28 ? -34.830 25.908 -20.129 1.00 63.68 ? 29 GLN A CD 1 ATOM 211 O OE1 . GLN A 1 28 ? -33.733 25.732 -20.650 1.00 73.12 ? 29 GLN A OE1 1 ATOM 212 N NE2 . GLN A 1 28 ? -35.955 25.883 -20.823 1.00 61.13 ? 29 GLN A NE2 1 ATOM 213 N N . VAL A 1 29 ? -32.777 24.947 -15.302 1.00 50.87 ? 30 VAL A N 1 ATOM 214 C CA . VAL A 1 29 ? -32.765 23.728 -14.502 1.00 50.94 ? 30 VAL A CA 1 ATOM 215 C C . VAL A 1 29 ? -33.298 23.976 -13.071 1.00 46.42 ? 30 VAL A C 1 ATOM 216 O O . VAL A 1 29 ? -34.187 23.251 -12.605 1.00 43.49 ? 30 VAL A O 1 ATOM 217 C CB . VAL A 1 29 ? -31.376 23.033 -14.571 1.00 51.04 ? 30 VAL A CB 1 ATOM 218 C CG1 . VAL A 1 29 ? -31.075 22.169 -13.342 1.00 51.38 ? 30 VAL A CG1 1 ATOM 219 C CG2 . VAL A 1 29 ? -31.329 22.194 -15.825 1.00 48.41 ? 30 VAL A CG2 1 ATOM 220 N N . VAL A 1 30 ? -32.778 25.013 -12.417 1.00 40.96 ? 31 VAL A N 1 ATOM 221 C CA . VAL A 1 30 ? -33.293 25.453 -11.124 1.00 43.65 ? 31 VAL A CA 1 ATOM 222 C C . VAL A 1 30 ? -34.829 25.611 -11.175 1.00 47.55 ? 31 VAL A C 1 ATOM 223 O O . VAL A 1 30 ? -35.543 25.009 -10.360 1.00 47.92 ? 31 VAL A O 1 ATOM 224 C CB . VAL A 1 30 ? -32.583 26.733 -10.624 1.00 38.88 ? 31 VAL A CB 1 ATOM 225 C CG1 . VAL A 1 30 ? -33.149 27.181 -9.309 1.00 36.32 ? 31 VAL A CG1 1 ATOM 226 C CG2 . VAL A 1 30 ? -31.108 26.460 -10.408 1.00 40.50 ? 31 VAL A CG2 1 ATOM 227 N N . CYS A 1 31 ? -35.318 26.369 -12.161 1.00 49.75 ? 32 CYS A N 1 ATOM 228 C CA . CYS A 1 31 ? -36.755 26.560 -12.393 1.00 48.58 ? 32 CYS A CA 1 ATOM 229 C C . CYS A 1 31 ? -37.501 25.236 -12.480 1.00 47.41 ? 32 CYS A C 1 ATOM 230 O O . CYS A 1 31 ? -38.508 25.023 -11.801 1.00 46.04 ? 32 CYS A O 1 ATOM 231 C CB . CYS A 1 31 ? -37.019 27.392 -13.647 1.00 46.99 ? 32 CYS A CB 1 ATOM 232 S SG . CYS A 1 31 ? -38.761 27.822 -13.827 1.00 65.01 ? 32 CYS A SG 1 ATOM 233 N N . THR A 1 32 ? -36.977 24.332 -13.286 1.00 47.74 ? 33 THR A N 1 ATOM 234 C CA . THR A 1 32 ? -37.604 23.046 -13.462 1.00 49.46 ? 33 THR A CA 1 ATOM 235 C C . THR A 1 32 ? -37.691 22.275 -12.161 1.00 51.41 ? 33 THR A C 1 ATOM 236 O O . THR A 1 32 ? -38.729 21.685 -11.875 1.00 58.40 ? 33 THR A O 1 ATOM 237 C CB . THR A 1 32 ? -36.870 22.250 -14.520 1.00 49.77 ? 33 THR A CB 1 ATOM 238 O OG1 . THR A 1 32 ? -36.835 23.048 -15.703 1.00 57.51 ? 33 THR A OG1 1 ATOM 239 C CG2 . THR A 1 32 ? -37.585 20.948 -14.812 1.00 45.83 ? 33 THR A CG2 1 ATOM 240 N N . TYR A 1 33 ? -36.628 22.319 -11.365 1.00 50.11 ? 34 TYR A N 1 ATOM 241 C CA . TYR A 1 33 ? -36.532 21.497 -10.163 1.00 47.41 ? 34 TYR A CA 1 ATOM 242 C C . TYR A 1 33 ? -37.176 22.141 -8.930 1.00 47.33 ? 34 TYR A C 1 ATOM 243 O O . TYR A 1 33 ? -37.303 21.516 -7.882 1.00 50.85 ? 34 TYR A O 1 ATOM 244 C CB . TYR A 1 33 ? -35.077 21.096 -9.914 1.00 47.59 ? 34 TYR A CB 1 ATOM 245 C CG . TYR A 1 33 ? -34.673 19.883 -10.696 1.00 55.13 ? 34 TYR A CG 1 ATOM 246 C CD1 . TYR A 1 33 ? -34.383 19.959 -12.064 1.00 64.12 ? 34 TYR A CD1 1 ATOM 247 C CD2 . TYR A 1 33 ? -34.582 18.640 -10.077 1.00 63.05 ? 34 TYR A CD2 1 ATOM 248 C CE1 . TYR A 1 33 ? -34.032 18.814 -12.789 1.00 70.87 ? 34 TYR A CE1 1 ATOM 249 C CE2 . TYR A 1 33 ? -34.221 17.492 -10.784 1.00 66.93 ? 34 TYR A CE2 1 ATOM 250 C CZ . TYR A 1 33 ? -33.955 17.579 -12.134 1.00 69.35 ? 34 TYR A CZ 1 ATOM 251 O OH . TYR A 1 33 ? -33.611 16.434 -12.809 1.00 73.26 ? 34 TYR A OH 1 ATOM 252 N N . HIS A 1 34 ? -37.603 23.383 -9.061 1.00 45.54 ? 35 HIS A N 1 ATOM 253 C CA . HIS A 1 34 ? -38.234 24.088 -7.966 1.00 45.96 ? 35 HIS A CA 1 ATOM 254 C C . HIS A 1 34 ? -39.722 23.714 -7.933 1.00 45.81 ? 35 HIS A C 1 ATOM 255 O O . HIS A 1 34 ? -40.323 23.569 -8.987 1.00 49.89 ? 35 HIS A O 1 ATOM 256 C CB . HIS A 1 34 ? -38.052 25.566 -8.219 1.00 50.89 ? 35 HIS A CB 1 ATOM 257 C CG . HIS A 1 34 ? -38.649 26.421 -7.170 1.00 50.92 ? 35 HIS A CG 1 ATOM 258 N ND1 . HIS A 1 34 ? -39.978 26.766 -7.175 1.00 49.67 ? 35 HIS A ND1 1 ATOM 259 C CD2 . HIS A 1 34 ? -38.111 26.971 -6.060 1.00 53.95 ? 35 HIS A CD2 1 ATOM 260 C CE1 . HIS A 1 34 ? -40.239 27.488 -6.102 1.00 56.26 ? 35 HIS A CE1 1 ATOM 261 N NE2 . HIS A 1 34 ? -39.121 27.635 -5.412 1.00 55.26 ? 35 HIS A NE2 1 ATOM 262 N N . PRO A 1 35 ? -40.344 23.599 -6.742 1.00 45.80 ? 36 PRO A N 1 ATOM 263 C CA . PRO A 1 35 ? -41.644 22.930 -6.772 1.00 47.71 ? 36 PRO A CA 1 ATOM 264 C C . PRO A 1 35 ? -42.785 23.785 -7.304 1.00 49.78 ? 36 PRO A C 1 ATOM 265 O O . PRO A 1 35 ? -43.859 23.257 -7.609 1.00 59.38 ? 36 PRO A O 1 ATOM 266 C CB . PRO A 1 35 ? -41.883 22.590 -5.316 1.00 47.30 ? 36 PRO A CB 1 ATOM 267 C CG . PRO A 1 35 ? -41.248 23.725 -4.594 1.00 50.86 ? 36 PRO A CG 1 ATOM 268 C CD . PRO A 1 35 ? -40.039 24.108 -5.393 1.00 48.93 ? 36 PRO A CD 1 ATOM 269 N N . ARG A 1 36 ? -42.545 25.080 -7.439 1.00 47.28 ? 37 ARG A N 1 ATOM 270 C CA . ARG A 1 36 ? -43.575 25.991 -7.868 1.00 46.02 ? 37 ARG A CA 1 ATOM 271 C C . ARG A 1 36 ? -43.230 26.769 -9.152 1.00 46.08 ? 37 ARG A C 1 ATOM 272 O O . ARG A 1 36 ? -44.135 27.291 -9.809 1.00 46.72 ? 37 ARG A O 1 ATOM 273 C CB . ARG A 1 36 ? -43.997 26.908 -6.701 1.00 47.29 ? 37 ARG A CB 1 ATOM 274 C CG . ARG A 1 36 ? -45.457 27.306 -6.798 1.00 52.79 ? 37 ARG A CG 1 ATOM 275 C CD . ARG A 1 36 ? -46.092 27.702 -5.500 1.00 53.76 ? 37 ARG A CD 1 ATOM 276 N NE . ARG A 1 36 ? -45.850 29.103 -5.187 1.00 72.21 ? 37 ARG A NE 1 ATOM 277 C CZ . ARG A 1 36 ? -44.846 29.544 -4.415 1.00 87.01 ? 37 ARG A CZ 1 ATOM 278 N NH1 . ARG A 1 36 ? -43.950 28.686 -3.885 1.00 83.43 ? 37 ARG A NH1 1 ATOM 279 N NH2 . ARG A 1 36 ? -44.736 30.854 -4.163 1.00 75.09 ? 37 ARG A NH2 1 ATOM 280 N N . CYS A 1 37 ? -41.950 26.828 -9.527 1.00 49.56 ? 38 CYS A N 1 ATOM 281 C CA . CYS A 1 37 ? -41.509 27.609 -10.702 1.00 53.26 ? 38 CYS A CA 1 ATOM 282 C C . CYS A 1 37 ? -42.100 27.124 -12.038 1.00 51.22 ? 38 CYS A C 1 ATOM 283 O O . CYS A 1 37 ? -42.101 25.935 -12.330 1.00 54.81 ? 38 CYS A O 1 ATOM 284 C CB . CYS A 1 37 ? -39.980 27.629 -10.803 1.00 52.95 ? 38 CYS A CB 1 ATOM 285 S SG . CYS A 1 37 ? -39.333 28.811 -12.038 1.00 70.34 ? 38 CYS A SG 1 ATOM 286 N N . LEU A 1 38 ? -42.584 28.042 -12.858 1.00 49.68 ? 39 LEU A N 1 ATOM 287 C CA . LEU A 1 38 ? -43.000 27.673 -14.220 1.00 54.38 ? 39 LEU A CA 1 ATOM 288 C C . LEU A 1 38 ? -42.155 28.289 -15.314 1.00 57.81 ? 39 LEU A C 1 ATOM 289 O O . LEU A 1 38 ? -42.147 27.793 -16.453 1.00 59.99 ? 39 LEU A O 1 ATOM 290 C CB . LEU A 1 38 ? -44.442 28.072 -14.478 1.00 49.85 ? 39 LEU A CB 1 ATOM 291 C CG . LEU A 1 38 ? -45.475 27.415 -13.581 1.00 49.54 ? 39 LEU A CG 1 ATOM 292 C CD1 . LEU A 1 38 ? -46.843 27.965 -13.970 1.00 49.67 ? 39 LEU A CD1 1 ATOM 293 C CD2 . LEU A 1 38 ? -45.409 25.896 -13.658 1.00 45.95 ? 39 LEU A CD2 1 ATOM 294 N N . LEU A 1 39 ? -41.468 29.370 -14.948 1.00 52.70 ? 40 LEU A N 1 ATOM 295 C CA . LEU A 1 39 ? -40.863 30.272 -15.877 1.00 50.77 ? 40 LEU A CA 1 ATOM 296 C C . LEU A 1 39 ? -39.929 31.205 -15.155 1.00 51.65 ? 40 LEU A C 1 ATOM 297 O O . LEU A 1 39 ? -40.130 31.506 -13.986 1.00 54.15 ? 40 LEU A O 1 ATOM 298 C CB . LEU A 1 39 ? -41.938 31.070 -16.637 1.00 53.70 ? 40 LEU A CB 1 ATOM 299 C CG . LEU A 1 39 ? -43.135 31.815 -16.067 1.00 57.08 ? 40 LEU A CG 1 ATOM 300 C CD1 . LEU A 1 39 ? -42.698 33.155 -15.573 1.00 69.16 ? 40 LEU A CD1 1 ATOM 301 C CD2 . LEU A 1 39 ? -44.098 32.094 -17.198 1.00 63.96 ? 40 LEU A CD2 1 ATOM 302 N N . PHE A 1 40 ? -38.933 31.703 -15.873 1.00 53.90 ? 41 PHE A N 1 ATOM 303 C CA . PHE A 1 40 ? -37.871 32.485 -15.268 1.00 57.74 ? 41 PHE A CA 1 ATOM 304 C C . PHE A 1 40 ? -37.299 33.593 -16.176 1.00 63.05 ? 41 PHE A C 1 ATOM 305 O O . PHE A 1 40 ? -37.499 33.599 -17.399 1.00 58.52 ? 41 PHE A O 1 ATOM 306 C CB . PHE A 1 40 ? -36.740 31.550 -14.901 1.00 54.84 ? 41 PHE A CB 1 ATOM 307 C CG . PHE A 1 40 ? -36.030 31.016 -16.098 1.00 57.32 ? 41 PHE A CG 1 ATOM 308 C CD1 . PHE A 1 40 ? -34.944 31.690 -16.639 1.00 57.53 ? 41 PHE A CD1 1 ATOM 309 C CD2 . PHE A 1 40 ? -36.474 29.862 -16.711 1.00 60.61 ? 41 PHE A CD2 1 ATOM 310 C CE1 . PHE A 1 40 ? -34.296 31.198 -17.746 1.00 61.12 ? 41 PHE A CE1 1 ATOM 311 C CE2 . PHE A 1 40 ? -35.843 29.369 -17.832 1.00 61.31 ? 41 PHE A CE2 1 ATOM 312 C CZ . PHE A 1 40 ? -34.751 30.035 -18.351 1.00 63.33 ? 41 PHE A CZ 1 ATOM 313 N N . THR A 1 41 ? -36.529 34.480 -15.545 1.00 60.62 ? 42 THR A N 1 ATOM 314 C CA . THR A 1 41 ? -35.849 35.574 -16.189 1.00 65.08 ? 42 THR A CA 1 ATOM 315 C C . THR A 1 41 ? -34.455 35.703 -15.577 1.00 74.31 ? 42 THR A C 1 ATOM 316 O O . THR A 1 41 ? -34.289 36.058 -14.392 1.00 80.17 ? 42 THR A O 1 ATOM 317 C CB . THR A 1 41 ? -36.648 36.874 -16.027 1.00 65.86 ? 42 THR A CB 1 ATOM 318 O OG1 . THR A 1 41 ? -37.864 36.755 -16.757 1.00 73.77 ? 42 THR A OG1 1 ATOM 319 C CG2 . THR A 1 41 ? -35.889 38.077 -16.554 1.00 66.87 ? 42 THR A CG2 1 ATOM 320 N N . PHE A 1 42 ? -33.463 35.407 -16.413 1.00 76.64 ? 43 PHE A N 1 ATOM 321 C CA . PHE A 1 42 ? -32.051 35.464 -16.059 1.00 71.32 ? 43 PHE A CA 1 ATOM 322 C C . PHE A 1 42 ? -31.417 36.756 -16.572 1.00 70.65 ? 43 PHE A C 1 ATOM 323 O O . PHE A 1 42 ? -31.752 37.231 -17.663 1.00 67.69 ? 43 PHE A O 1 ATOM 324 C CB . PHE A 1 42 ? -31.332 34.241 -16.646 1.00 72.35 ? 43 PHE A CB 1 ATOM 325 C CG . PHE A 1 42 ? -29.848 34.307 -16.536 1.00 68.07 ? 43 PHE A CG 1 ATOM 326 C CD1 . PHE A 1 42 ? -29.217 33.958 -15.351 1.00 72.22 ? 43 PHE A CD1 1 ATOM 327 C CD2 . PHE A 1 42 ? -29.083 34.752 -17.607 1.00 65.89 ? 43 PHE A CD2 1 ATOM 328 C CE1 . PHE A 1 42 ? -27.840 34.036 -15.232 1.00 72.53 ? 43 PHE A CE1 1 ATOM 329 C CE2 . PHE A 1 42 ? -27.711 34.837 -17.499 1.00 66.92 ? 43 PHE A CE2 1 ATOM 330 C CZ . PHE A 1 42 ? -27.088 34.476 -16.309 1.00 70.56 ? 43 PHE A CZ 1 ATOM 331 N N . THR A 1 43 ? -30.487 37.300 -15.789 1.00 73.04 ? 44 THR A N 1 ATOM 332 C CA . THR A 1 43 ? -29.739 38.503 -16.164 1.00 71.74 ? 44 THR A CA 1 ATOM 333 C C . THR A 1 43 ? -28.291 38.155 -16.475 1.00 77.80 ? 44 THR A C 1 ATOM 334 O O . THR A 1 43 ? -27.545 37.661 -15.611 1.00 77.08 ? 44 THR A O 1 ATOM 335 C CB . THR A 1 43 ? -29.748 39.550 -15.045 1.00 71.65 ? 44 THR A CB 1 ATOM 336 O OG1 . THR A 1 43 ? -31.102 39.869 -14.691 1.00 78.21 ? 44 THR A OG1 1 ATOM 337 C CG2 . THR A 1 43 ? -29.011 40.806 -15.491 1.00 69.00 ? 44 THR A CG2 1 ATOM 338 N N . ALA A 1 44 ? -27.903 38.444 -17.712 1.00 79.44 ? 45 ALA A N 1 ATOM 339 C CA . ALA A 1 44 ? -26.549 38.210 -18.191 1.00 76.63 ? 45 ALA A CA 1 ATOM 340 C C . ALA A 1 44 ? -25.579 39.373 -17.873 1.00 82.04 ? 45 ALA A C 1 ATOM 341 O O . ALA A 1 44 ? -26.003 40.478 -17.487 1.00 81.48 ? 45 ALA A O 1 ATOM 342 C CB . ALA A 1 44 ? -26.589 37.902 -19.686 1.00 77.67 ? 45 ALA A CB 1 ATOM 343 N N . GLU A 1 45 ? -24.277 39.107 -18.027 1.00 88.52 ? 46 GLU A N 1 ATOM 344 C CA . GLU A 1 45 ? -23.229 40.124 -17.875 1.00 87.21 ? 46 GLU A CA 1 ATOM 345 C C . GLU A 1 45 ? -23.375 41.130 -19.001 1.00 85.67 ? 46 GLU A C 1 ATOM 346 O O . GLU A 1 45 ? -23.379 40.741 -20.176 1.00 85.30 ? 46 GLU A O 1 ATOM 347 C CB . GLU A 1 45 ? -21.852 39.473 -17.955 1.00 89.74 ? 46 GLU A CB 1 ATOM 348 C CG . GLU A 1 45 ? -20.826 40.087 -17.014 1.00 97.81 ? 46 GLU A CG 1 ATOM 349 C CD . GLU A 1 45 ? -19.403 39.592 -17.251 1.00 107.75 ? 46 GLU A CD 1 ATOM 350 O OE1 . GLU A 1 45 ? -19.201 38.494 -17.830 1.00 112.49 ? 46 GLU A OE1 1 ATOM 351 O OE2 . GLU A 1 45 ? -18.468 40.315 -16.847 1.00 114.41 ? 46 GLU A OE2 1 ATOM 352 N N . SER A 1 46 ? -23.529 42.408 -18.653 1.00 84.64 ? 47 SER A N 1 ATOM 353 C CA . SER A 1 46 ? -23.678 43.457 -19.665 1.00 82.83 ? 47 SER A CA 1 ATOM 354 C C . SER A 1 46 ? -23.428 44.870 -19.169 1.00 86.39 ? 47 SER A C 1 ATOM 355 O O . SER A 1 46 ? -23.774 45.196 -18.015 1.00 73.17 ? 47 SER A O 1 ATOM 356 C CB . SER A 1 46 ? -25.066 43.423 -20.308 1.00 79.83 ? 47 SER A CB 1 ATOM 357 O OG . SER A 1 46 ? -24.996 43.935 -21.630 1.00 82.89 ? 47 SER A OG 1 ATOM 358 N N . PRO A 1 47 ? -22.838 45.717 -20.060 1.00 93.60 ? 48 PRO A N 1 ATOM 359 C CA . PRO A 1 47 ? -22.914 47.181 -20.071 1.00 87.39 ? 48 PRO A CA 1 ATOM 360 C C . PRO A 1 47 ? -24.197 47.709 -19.433 1.00 88.27 ? 48 PRO A C 1 ATOM 361 O O . PRO A 1 47 ? -24.124 48.472 -18.470 1.00 84.00 ? 48 PRO A O 1 ATOM 362 C CB . PRO A 1 47 ? -22.936 47.501 -21.580 1.00 89.76 ? 48 PRO A CB 1 ATOM 363 C CG . PRO A 1 47 ? -22.608 46.196 -22.293 1.00 90.46 ? 48 PRO A CG 1 ATOM 364 C CD . PRO A 1 47 ? -22.075 45.269 -21.237 1.00 87.63 ? 48 PRO A CD 1 ATOM 365 N N . SER A 1 48 ? -25.345 47.245 -19.945 1.00 84.92 ? 49 SER A N 1 ATOM 366 C CA . SER A 1 48 ? -26.693 47.661 -19.520 1.00 83.27 ? 49 SER A CA 1 ATOM 367 C C . SER A 1 48 ? -27.069 47.521 -18.035 1.00 88.69 ? 49 SER A C 1 ATOM 368 O O . SER A 1 48 ? -27.999 48.191 -17.579 1.00 91.76 ? 49 SER A O 1 ATOM 369 C CB . SER A 1 48 ? -27.739 46.930 -20.358 1.00 80.60 ? 49 SER A CB 1 ATOM 370 O OG . SER A 1 48 ? -27.411 47.011 -21.730 1.00 80.04 ? 49 SER A OG 1 ATOM 371 N N . GLU A 1 49 ? -26.366 46.667 -17.290 1.00 90.51 ? 50 GLU A N 1 ATOM 372 C CA . GLU A 1 49 ? -26.779 46.315 -15.925 1.00 89.76 ? 50 GLU A CA 1 ATOM 373 C C . GLU A 1 49 ? -25.685 46.591 -14.898 1.00 91.10 ? 50 GLU A C 1 ATOM 374 O O . GLU A 1 49 ? -24.494 46.417 -15.199 1.00 83.27 ? 50 GLU A O 1 ATOM 375 C CB . GLU A 1 49 ? -27.169 44.824 -15.856 1.00 97.16 ? 50 GLU A CB 1 ATOM 376 C CG . GLU A 1 49 ? -28.316 44.364 -16.757 1.00 92.98 ? 50 GLU A CG 1 ATOM 377 C CD . GLU A 1 49 ? -29.697 44.854 -16.311 1.00 95.59 ? 50 GLU A CD 1 ATOM 378 O OE1 . GLU A 1 49 ? -29.897 45.148 -15.105 1.00 86.10 ? 50 GLU A OE1 1 ATOM 379 O OE2 . GLU A 1 49 ? -30.594 44.939 -17.186 1.00 96.53 ? 50 GLU A OE2 1 ATOM 380 N N . ASP A 1 50 ? -26.092 46.990 -13.685 1.00 95.69 ? 51 ASP A N 1 ATOM 381 C CA . ASP A 1 50 ? -25.158 47.118 -12.540 1.00 102.28 ? 51 ASP A CA 1 ATOM 382 C C . ASP A 1 50 ? -24.583 45.743 -12.292 1.00 98.19 ? 51 ASP A C 1 ATOM 383 O O . ASP A 1 50 ? -25.315 44.756 -12.382 1.00 97.90 ? 51 ASP A O 1 ATOM 384 C CB . ASP A 1 50 ? -25.809 47.578 -11.212 1.00 112.40 ? 51 ASP A CB 1 ATOM 385 C CG . ASP A 1 50 ? -27.304 47.921 -11.329 1.00 125.51 ? 51 ASP A CG 1 ATOM 386 O OD1 . ASP A 1 50 ? -27.999 47.458 -12.268 1.00 124.72 ? 51 ASP A OD1 1 ATOM 387 O OD2 . ASP A 1 50 ? -27.791 48.648 -10.434 1.00 126.38 ? 51 ASP A OD2 1 ATOM 388 N N . PRO A 1 51 ? -23.284 45.664 -11.969 1.00 101.19 ? 52 PRO A N 1 ATOM 389 C CA . PRO A 1 51 ? -22.661 44.366 -11.657 1.00 102.60 ? 52 PRO A CA 1 ATOM 390 C C . PRO A 1 51 ? -23.379 43.514 -10.575 1.00 100.78 ? 52 PRO A C 1 ATOM 391 O O . PRO A 1 51 ? -23.236 42.284 -10.581 1.00 91.69 ? 52 PRO A O 1 ATOM 392 C CB . PRO A 1 51 ? -21.250 44.760 -11.209 1.00 98.93 ? 52 PRO A CB 1 ATOM 393 C CG . PRO A 1 51 ? -20.974 46.006 -11.976 1.00 102.71 ? 52 PRO A CG 1 ATOM 394 C CD . PRO A 1 51 ? -22.285 46.750 -11.991 1.00 104.16 ? 52 PRO A CD 1 ATOM 395 N N . THR A 1 52 ? -24.148 44.160 -9.687 1.00 98.66 ? 53 THR A N 1 ATOM 396 C CA . THR A 1 52 ? -24.890 43.458 -8.623 1.00 90.66 ? 53 THR A CA 1 ATOM 397 C C . THR A 1 52 ? -26.077 42.694 -9.166 1.00 85.93 ? 53 THR A C 1 ATOM 398 O O . THR A 1 52 ? -26.423 41.641 -8.646 1.00 93.56 ? 53 THR A O 1 ATOM 399 C CB . THR A 1 52 ? -25.405 44.388 -7.490 1.00 88.53 ? 53 THR A CB 1 ATOM 400 O OG1 . THR A 1 52 ? -26.031 45.558 -8.047 1.00 94.34 ? 53 THR A OG1 1 ATOM 401 C CG2 . THR A 1 52 ? -24.281 44.748 -6.505 1.00 73.25 ? 53 THR A CG2 1 ATOM 402 N N . ARG A 1 53 ? -26.697 43.225 -10.208 1.00 85.70 ? 54 ARG A N 1 ATOM 403 C CA . ARG A 1 53 ? -27.906 42.628 -10.742 1.00 87.53 ? 54 ARG A CA 1 ATOM 404 C C . ARG A 1 53 ? -27.642 41.517 -11.765 1.00 87.85 ? 54 ARG A C 1 ATOM 405 O O . ARG A 1 53 ? -28.579 40.906 -12.274 1.00 94.56 ? 54 ARG A O 1 ATOM 406 C CB . ARG A 1 53 ? -28.845 43.711 -11.273 1.00 94.86 ? 54 ARG A CB 1 ATOM 407 C CG . ARG A 1 53 ? -29.655 44.390 -10.163 1.00 97.99 ? 54 ARG A CG 1 ATOM 408 C CD . ARG A 1 53 ? -31.112 44.626 -10.557 1.00 101.78 ? 54 ARG A CD 1 ATOM 409 N NE . ARG A 1 53 ? -31.651 43.576 -11.444 1.00 115.55 ? 54 ARG A NE 1 ATOM 410 C CZ . ARG A 1 53 ? -32.041 42.345 -11.079 1.00 114.42 ? 54 ARG A CZ 1 ATOM 411 N NH1 . ARG A 1 53 ? -31.970 41.939 -9.811 1.00 99.72 ? 54 ARG A NH1 1 ATOM 412 N NH2 . ARG A 1 53 ? -32.505 41.502 -12.003 1.00 107.31 ? 54 ARG A NH2 1 ATOM 413 N N . TRP A 1 54 ? -26.365 41.234 -12.026 1.00 87.36 ? 55 TRP A N 1 ATOM 414 C CA . TRP A 1 54 ? -25.956 40.162 -12.944 1.00 84.59 ? 55 TRP A CA 1 ATOM 415 C C . TRP A 1 54 ? -26.233 38.812 -12.329 1.00 78.19 ? 55 TRP A C 1 ATOM 416 O O . TRP A 1 54 ? -26.524 38.738 -11.141 1.00 90.51 ? 55 TRP A O 1 ATOM 417 C CB . TRP A 1 54 ? -24.459 40.238 -13.234 1.00 89.40 ? 55 TRP A CB 1 ATOM 418 C CG . TRP A 1 54 ? -23.960 41.391 -14.086 1.00 92.79 ? 55 TRP A CG 1 ATOM 419 C CD1 . TRP A 1 54 ? -24.680 42.185 -14.942 1.00 92.19 ? 55 TRP A CD1 1 ATOM 420 C CD2 . TRP A 1 54 ? -22.606 41.823 -14.192 1.00 96.92 ? 55 TRP A CD2 1 ATOM 421 N NE1 . TRP A 1 54 ? -23.859 43.105 -15.540 1.00 91.10 ? 55 TRP A NE1 1 ATOM 422 C CE2 . TRP A 1 54 ? -22.579 42.901 -15.101 1.00 99.76 ? 55 TRP A CE2 1 ATOM 423 C CE3 . TRP A 1 54 ? -21.405 41.409 -13.589 1.00 101.80 ? 55 TRP A CE3 1 ATOM 424 C CZ2 . TRP A 1 54 ? -21.397 43.574 -15.426 1.00 113.40 ? 55 TRP A CZ2 1 ATOM 425 C CZ3 . TRP A 1 54 ? -20.227 42.075 -13.912 1.00 106.99 ? 55 TRP A CZ3 1 ATOM 426 C CH2 . TRP A 1 54 ? -20.233 43.149 -14.822 1.00 113.79 ? 55 TRP A CH2 1 ATOM 427 N N . PHE A 1 55 ? -26.152 37.751 -13.133 1.00 69.65 ? 56 PHE A N 1 ATOM 428 C CA . PHE A 1 55 ? -26.274 36.357 -12.658 1.00 65.64 ? 56 PHE A CA 1 ATOM 429 C C . PHE A 1 55 ? -27.480 36.094 -11.812 1.00 65.75 ? 56 PHE A C 1 ATOM 430 O O . PHE A 1 55 ? -27.514 35.164 -11.027 1.00 70.00 ? 56 PHE A O 1 ATOM 431 C CB . PHE A 1 55 ? -25.037 35.957 -11.885 1.00 66.27 ? 56 PHE A CB 1 ATOM 432 C CG . PHE A 1 55 ? -23.821 35.992 -12.716 1.00 76.50 ? 56 PHE A CG 1 ATOM 433 C CD1 . PHE A 1 55 ? -23.568 34.962 -13.650 1.00 74.52 ? 56 PHE A CD1 1 ATOM 434 C CD2 . PHE A 1 55 ? -22.948 37.074 -12.634 1.00 74.00 ? 56 PHE A CD2 1 ATOM 435 C CE1 . PHE A 1 55 ? -22.441 35.006 -14.461 1.00 68.57 ? 56 PHE A CE1 1 ATOM 436 C CE2 . PHE A 1 55 ? -21.818 37.115 -13.444 1.00 75.13 ? 56 PHE A CE2 1 ATOM 437 C CZ . PHE A 1 55 ? -21.567 36.086 -14.355 1.00 69.69 ? 56 PHE A CZ 1 ATOM 438 N N . THR A 1 56 ? -28.463 36.952 -11.986 1.00 70.70 ? 57 THR A N 1 ATOM 439 C CA . THR A 1 56 ? -29.676 36.918 -11.245 1.00 67.74 ? 57 THR A CA 1 ATOM 440 C C . THR A 1 56 ? -30.625 36.072 -12.046 1.00 69.32 ? 57 THR A C 1 ATOM 441 O O . THR A 1 56 ? -30.810 36.282 -13.263 1.00 64.03 ? 57 THR A O 1 ATOM 442 C CB . THR A 1 56 ? -30.151 38.353 -11.013 1.00 68.08 ? 57 THR A CB 1 ATOM 443 O OG1 . THR A 1 56 ? -29.538 38.802 -9.806 1.00 65.77 ? 57 THR A OG1 1 ATOM 444 C CG2 . THR A 1 56 ? -31.664 38.466 -10.891 1.00 71.32 ? 57 THR A CG2 1 ATOM 445 N N . CYS A 1 57 ? -31.172 35.081 -11.343 1.00 67.67 ? 58 CYS A N 1 ATOM 446 C CA . CYS A 1 57 ? -32.152 34.160 -11.888 1.00 62.72 ? 58 CYS A CA 1 ATOM 447 C C . CYS A 1 57 ? -33.411 34.337 -11.075 1.00 58.33 ? 58 CYS A C 1 ATOM 448 O O . CYS A 1 57 ? -33.433 34.021 -9.892 1.00 64.56 ? 58 CYS A O 1 ATOM 449 C CB . CYS A 1 57 ? -31.613 32.740 -11.788 1.00 62.82 ? 58 CYS A CB 1 ATOM 450 S SG . CYS A 1 57 ? -32.791 31.454 -12.204 1.00 68.04 ? 58 CYS A SG 1 ATOM 451 N N . VAL A 1 58 ? -34.446 34.894 -11.684 1.00 55.39 ? 59 VAL A N 1 ATOM 452 C CA . VAL A 1 58 ? -35.706 35.052 -10.969 1.00 57.42 ? 59 VAL A CA 1 ATOM 453 C C . VAL A 1 58 ? -36.739 34.017 -11.396 1.00 56.62 ? 59 VAL A C 1 ATOM 454 O O . VAL A 1 58 ? -37.212 34.010 -12.527 1.00 60.28 ? 59 VAL A O 1 ATOM 455 C CB . VAL A 1 58 ? -36.247 36.494 -11.046 1.00 61.03 ? 59 VAL A CB 1 ATOM 456 C CG1 . VAL A 1 58 ? -37.680 36.583 -10.541 1.00 63.58 ? 59 VAL A CG1 1 ATOM 457 C CG2 . VAL A 1 58 ? -35.363 37.411 -10.221 1.00 63.75 ? 59 VAL A CG2 1 ATOM 458 N N . LEU A 1 59 ? -37.055 33.133 -10.461 1.00 54.83 ? 60 LEU A N 1 ATOM 459 C CA . LEU A 1 59 ? -38.085 32.109 -10.618 1.00 50.82 ? 60 LEU A CA 1 ATOM 460 C C . LEU A 1 59 ? -39.455 32.735 -10.410 1.00 50.86 ? 60 LEU A C 1 ATOM 461 O O . LEU A 1 59 ? -39.614 33.606 -9.546 1.00 51.37 ? 60 LEU A O 1 ATOM 462 C CB . LEU A 1 59 ? -37.848 31.006 -9.594 1.00 47.96 ? 60 LEU A CB 1 ATOM 463 C CG . LEU A 1 59 ? -36.389 30.552 -9.520 1.00 47.33 ? 60 LEU A CG 1 ATOM 464 C CD1 . LEU A 1 59 ? -36.133 29.623 -8.358 1.00 46.39 ? 60 LEU A CD1 1 ATOM 465 C CD2 . LEU A 1 59 ? -36.010 29.867 -10.815 1.00 52.67 ? 60 LEU A CD2 1 ATOM 466 N N . LYS A 1 60 ? -40.432 32.322 -11.213 1.00 48.92 ? 61 LYS A N 1 ATOM 467 C CA . LYS A 1 60 ? -41.752 32.950 -11.193 1.00 51.66 ? 61 LYS A CA 1 ATOM 468 C C . LYS A 1 60 ? -42.872 31.927 -11.315 1.00 56.08 ? 61 LYS A C 1 ATOM 469 O O . LYS A 1 60 ? -42.662 30.807 -11.793 1.00 60.22 ? 61 LYS A O 1 ATOM 470 C CB . LYS A 1 60 ? -41.876 33.975 -12.319 1.00 50.16 ? 61 LYS A CB 1 ATOM 471 C CG . LYS A 1 60 ? -40.771 35.014 -12.385 1.00 51.01 ? 61 LYS A CG 1 ATOM 472 C CD . LYS A 1 60 ? -40.569 35.560 -13.787 1.00 51.37 ? 61 LYS A CD 1 ATOM 473 C CE . LYS A 1 60 ? -39.788 36.871 -13.754 1.00 57.29 ? 61 LYS A CE 1 ATOM 474 N NZ . LYS A 1 60 ? -40.543 38.071 -13.257 1.00 54.86 ? 61 LYS A NZ 1 ATOM 475 N N . ASP A 1 61 ? -44.063 32.327 -10.876 1.00 56.15 ? 62 ASP A N 1 ATOM 476 C CA . ASP A 1 61 ? -45.275 31.521 -11.013 1.00 56.05 ? 62 ASP A CA 1 ATOM 477 C C . ASP A 1 61 ? -46.316 32.417 -11.604 1.00 58.01 ? 62 ASP A C 1 ATOM 478 O O . ASP A 1 61 ? -46.347 33.605 -11.290 1.00 71.76 ? 62 ASP A O 1 ATOM 479 C CB . ASP A 1 61 ? -45.768 31.054 -9.639 1.00 60.84 ? 62 ASP A CB 1 ATOM 480 C CG . ASP A 1 61 ? -46.779 29.883 -9.698 1.00 59.07 ? 62 ASP A CG 1 ATOM 481 O OD1 . ASP A 1 61 ? -47.194 29.445 -10.810 1.00 58.69 ? 62 ASP A OD1 1 ATOM 482 O OD2 . ASP A 1 61 ? -47.140 29.407 -8.589 1.00 48.79 ? 62 ASP A OD2 1 ATOM 483 N N . SER A 1 62 ? -47.145 31.848 -12.471 1.00 55.89 ? 63 SER A N 1 ATOM 484 C CA . SER A 1 62 ? -48.344 32.494 -13.007 1.00 56.28 ? 63 SER A CA 1 ATOM 485 C C . SER A 1 62 ? -49.458 31.476 -13.008 1.00 55.88 ? 63 SER A C 1 ATOM 486 O O . SER A 1 62 ? -49.219 30.272 -13.110 1.00 59.46 ? 63 SER A O 1 ATOM 487 C CB . SER A 1 62 ? -48.138 33.031 -14.430 1.00 57.16 ? 63 SER A CB 1 ATOM 488 O OG . SER A 1 62 ? -49.393 33.196 -15.109 1.00 54.89 ? 63 SER A OG 1 ATOM 489 N N . VAL A 1 63 ? -50.671 31.977 -12.906 1.00 56.01 ? 64 VAL A N 1 ATOM 490 C CA . VAL A 1 63 ? -51.847 31.138 -12.807 1.00 63.38 ? 64 VAL A CA 1 ATOM 491 C C . VAL A 1 63 ? -52.286 30.754 -14.213 1.00 66.80 ? 64 VAL A C 1 ATOM 492 O O . VAL A 1 63 ? -52.857 29.677 -14.423 1.00 69.35 ? 64 VAL A O 1 ATOM 493 C CB . VAL A 1 63 ? -52.943 31.876 -11.992 1.00 63.11 ? 64 VAL A CB 1 ATOM 494 C CG1 . VAL A 1 63 ? -54.345 31.687 -12.558 1.00 61.48 ? 64 VAL A CG1 1 ATOM 495 C CG2 . VAL A 1 63 ? -52.867 31.468 -10.529 1.00 59.32 ? 64 VAL A CG2 1 ATOM 496 N N . THR A 1 64 ? -51.992 31.644 -15.161 1.00 68.47 ? 65 THR A N 1 ATOM 497 C CA . THR A 1 64 ? -52.353 31.475 -16.562 1.00 67.91 ? 65 THR A CA 1 ATOM 498 C C . THR A 1 64 ? -51.303 30.633 -17.222 1.00 66.65 ? 65 THR A C 1 ATOM 499 O O . THR A 1 64 ? -51.525 30.133 -18.312 1.00 74.80 ? 65 THR A O 1 ATOM 500 C CB . THR A 1 64 ? -52.446 32.822 -17.315 1.00 72.78 ? 65 THR A CB 1 ATOM 501 O OG1 . THR A 1 64 ? -51.140 33.398 -17.457 1.00 76.42 ? 65 THR A OG1 1 ATOM 502 C CG2 . THR A 1 64 ? -53.346 33.803 -16.565 1.00 78.86 ? 65 THR A CG2 1 ATOM 503 N N . GLU A 1 65 ? -50.161 30.488 -16.547 1.00 69.00 ? 66 GLU A N 1 ATOM 504 C CA . GLU A 1 65 ? -48.991 29.699 -16.998 1.00 71.02 ? 66 GLU A CA 1 ATOM 505 C C . GLU A 1 65 ? -48.032 30.458 -17.916 1.00 71.53 ? 66 GLU A C 1 ATOM 506 O O . GLU A 1 65 ? -46.991 29.940 -18.316 1.00 76.58 ? 66 GLU A O 1 ATOM 507 C CB . GLU A 1 65 ? -49.391 28.344 -17.594 1.00 69.51 ? 66 GLU A CB 1 ATOM 508 C CG . GLU A 1 65 ? -50.041 27.422 -16.577 1.00 71.90 ? 66 GLU A CG 1 ATOM 509 C CD . GLU A 1 65 ? -50.518 26.116 -17.167 1.00 78.89 ? 66 GLU A CD 1 ATOM 510 O OE1 . GLU A 1 65 ? -51.192 25.365 -16.436 1.00 82.88 ? 66 GLU A OE1 1 ATOM 511 O OE2 . GLU A 1 65 ? -50.229 25.829 -18.351 1.00 87.26 ? 66 GLU A OE2 1 ATOM 512 N N . THR A 1 66 ? -48.385 31.687 -18.246 1.00 70.30 ? 67 THR A N 1 ATOM 513 C CA . THR A 1 66 ? -47.417 32.604 -18.801 1.00 68.35 ? 67 THR A CA 1 ATOM 514 C C . THR A 1 66 ? -47.437 33.958 -18.083 1.00 68.06 ? 67 THR A C 1 ATOM 515 O O . THR A 1 66 ? -48.337 34.247 -17.281 1.00 59.08 ? 67 THR A O 1 ATOM 516 C CB . THR A 1 66 ? -47.612 32.804 -20.304 1.00 66.38 ? 67 THR A CB 1 ATOM 517 O OG1 . THR A 1 66 ? -46.496 33.541 -20.810 1.00 65.52 ? 67 THR A OG1 1 ATOM 518 C CG2 . THR A 1 66 ? -48.906 33.586 -20.592 1.00 70.88 ? 67 THR A CG2 1 ATOM 519 N N . LEU A 1 67 ? -46.428 34.771 -18.377 1.00 63.96 ? 68 LEU A N 1 ATOM 520 C CA . LEU A 1 67 ? -46.458 36.158 -18.006 1.00 62.83 ? 68 LEU A CA 1 ATOM 521 C C . LEU A 1 67 ? -46.263 37.045 -19.240 1.00 72.17 ? 68 LEU A C 1 ATOM 522 O O . LEU A 1 67 ? -45.852 36.537 -20.302 1.00 69.67 ? 68 LEU A O 1 ATOM 523 C CB . LEU A 1 67 ? -45.423 36.426 -16.930 1.00 61.40 ? 68 LEU A CB 1 ATOM 524 C CG . LEU A 1 67 ? -45.788 35.864 -15.560 1.00 61.12 ? 68 LEU A CG 1 ATOM 525 C CD1 . LEU A 1 67 ? -44.581 35.885 -14.651 1.00 59.80 ? 68 LEU A CD1 1 ATOM 526 C CD2 . LEU A 1 67 ? -46.929 36.626 -14.915 1.00 61.04 ? 68 LEU A CD2 1 ATOM 527 N N . PRO A 1 68 ? -46.643 38.349 -19.134 1.00 80.54 ? 69 PRO A N 1 ATOM 528 C CA . PRO A 1 68 ? -46.255 39.430 -20.064 1.00 81.46 ? 69 PRO A CA 1 ATOM 529 C C . PRO A 1 68 ? -44.749 39.591 -20.290 1.00 82.38 ? 69 PRO A C 1 ATOM 530 O O . PRO A 1 68 ? -43.970 39.800 -19.331 1.00 75.65 ? 69 PRO A O 1 ATOM 531 C CB . PRO A 1 68 ? -46.834 40.699 -19.411 1.00 73.74 ? 69 PRO A CB 1 ATOM 532 C CG . PRO A 1 68 ? -47.601 40.240 -18.212 1.00 75.39 ? 69 PRO A CG 1 ATOM 533 C CD . PRO A 1 68 ? -47.824 38.764 -18.355 1.00 79.46 ? 69 PRO A CD 1 ATOM 534 N N . ARG A 1 69 ? -44.383 39.489 -21.570 1.00 82.62 ? 70 ARG A N 1 ATOM 535 C CA . ARG A 1 69 ? -43.012 39.629 -22.054 1.00 84.30 ? 70 ARG A CA 1 ATOM 536 C C . ARG A 1 69 ? -42.658 41.111 -22.221 1.00 88.19 ? 70 ARG A C 1 ATOM 537 O O . ARG A 1 69 ? -43.453 41.867 -22.781 1.00 99.29 ? 70 ARG A O 1 ATOM 538 C CB . ARG A 1 69 ? -42.883 38.931 -23.408 1.00 72.33 ? 70 ARG A CB 1 ATOM 539 C CG . ARG A 1 69 ? -42.941 37.423 -23.387 1.00 64.25 ? 70 ARG A CG 1 ATOM 540 C CD . ARG A 1 69 ? -42.833 36.947 -24.825 1.00 69.80 ? 70 ARG A CD 1 ATOM 541 N NE . ARG A 1 69 ? -42.756 35.492 -24.965 1.00 74.56 ? 70 ARG A NE 1 ATOM 542 C CZ . ARG A 1 69 ? -43.758 34.637 -24.742 1.00 77.62 ? 70 ARG A CZ 1 ATOM 543 N NH1 . ARG A 1 69 ? -43.565 33.332 -24.892 1.00 69.84 ? 70 ARG A NH1 1 ATOM 544 N NH2 . ARG A 1 69 ? -44.954 35.071 -24.351 1.00 88.22 ? 70 ARG A NH2 1 ATOM 545 N N . VAL A 1 70 ? -41.489 41.533 -21.734 1.00 88.67 ? 71 VAL A N 1 ATOM 546 C CA . VAL A 1 70 ? -40.983 42.898 -22.002 1.00 88.12 ? 71 VAL A CA 1 ATOM 547 C C . VAL A 1 70 ? -39.561 42.898 -22.586 1.00 91.96 ? 71 VAL A C 1 ATOM 548 O O . VAL A 1 70 ? -38.617 42.413 -21.953 1.00 100.97 ? 71 VAL A O 1 ATOM 549 C CB . VAL A 1 70 ? -41.145 43.896 -20.802 1.00 88.97 ? 71 VAL A CB 1 ATOM 550 C CG1 . VAL A 1 70 ? -42.601 44.015 -20.356 1.00 84.26 ? 71 VAL A CG1 1 ATOM 551 C CG2 . VAL A 1 70 ? -40.279 43.539 -19.602 1.00 98.17 ? 71 VAL A CG2 1 ATOM 552 N N . ASN A 1 71 ? -39.444 43.402 -23.819 1.00 100.16 ? 72 ASN A N 1 ATOM 553 C CA . ASN A 1 71 ? -38.162 43.667 -24.500 1.00 90.01 ? 72 ASN A CA 1 ATOM 554 C C . ASN A 1 71 ? -37.235 44.395 -23.502 1.00 83.00 ? 72 ASN A C 1 ATOM 555 O O . ASN A 1 71 ? -37.537 45.497 -23.043 1.00 89.35 ? 72 ASN A O 1 ATOM 556 C CB . ASN A 1 71 ? -38.402 44.518 -25.787 1.00 94.03 ? 72 ASN A CB 1 ATOM 557 C CG . ASN A 1 71 ? -38.626 43.679 -27.071 1.00 107.06 ? 72 ASN A CG 1 ATOM 558 O OD1 . ASN A 1 71 ? -38.049 42.598 -27.227 1.00 110.23 ? 72 ASN A OD1 1 ATOM 559 N ND2 . ASN A 1 71 ? -39.463 44.210 -28.013 1.00 110.01 ? 72 ASN A ND2 1 ATOM 560 N N . ARG A 1 72 ? -36.163 43.733 -23.086 1.00 77.43 ? 73 ARG A N 1 ATOM 561 C CA . ARG A 1 72 ? -35.157 44.346 -22.206 1.00 70.65 ? 73 ARG A CA 1 ATOM 562 C C . ARG A 1 72 ? -33.829 43.687 -22.456 1.00 74.77 ? 73 ARG A C 1 ATOM 563 O O . ARG A 1 72 ? -33.721 42.463 -22.510 1.00 80.56 ? 73 ARG A O 1 ATOM 564 C CB . ARG A 1 72 ? -35.537 44.245 -20.741 1.00 65.39 ? 73 ARG A CB 1 ATOM 565 C CG . ARG A 1 72 ? -34.372 44.393 -19.792 1.00 69.56 ? 73 ARG A CG 1 ATOM 566 C CD . ARG A 1 72 ? -34.805 45.106 -18.529 1.00 80.02 ? 73 ARG A CD 1 ATOM 567 N NE . ARG A 1 72 ? -33.641 45.582 -17.788 1.00 90.36 ? 73 ARG A NE 1 ATOM 568 C CZ . ARG A 1 72 ? -33.687 46.255 -16.641 1.00 96.49 ? 73 ARG A CZ 1 ATOM 569 N NH1 . ARG A 1 72 ? -34.851 46.558 -16.073 1.00 99.73 ? 73 ARG A NH1 1 ATOM 570 N NH2 . ARG A 1 72 ? -32.556 46.628 -16.057 1.00 99.94 ? 73 ARG A NH2 1 ATOM 571 N N . THR A 1 73 ? -32.814 44.514 -22.626 1.00 83.71 ? 74 THR A N 1 ATOM 572 C CA . THR A 1 73 ? -31.542 44.018 -23.103 1.00 86.62 ? 74 THR A CA 1 ATOM 573 C C . THR A 1 73 ? -30.805 43.331 -21.947 1.00 86.47 ? 74 THR A C 1 ATOM 574 O O . THR A 1 73 ? -30.958 43.727 -20.775 1.00 76.60 ? 74 THR A O 1 ATOM 575 C CB . THR A 1 73 ? -30.718 45.118 -23.826 1.00 88.06 ? 74 THR A CB 1 ATOM 576 O OG1 . THR A 1 73 ? -30.041 45.931 -22.860 1.00 94.07 ? 74 THR A OG1 1 ATOM 577 C CG2 . THR A 1 73 ? -31.628 46.016 -24.728 1.00 81.15 ? 74 THR A CG2 1 ATOM 578 N N . ALA A 1 74 ? -30.057 42.278 -22.309 1.00 91.19 ? 75 ALA A N 1 ATOM 579 C CA . ALA A 1 74 ? -29.230 41.421 -21.412 1.00 91.95 ? 75 ALA A CA 1 ATOM 580 C C . ALA A 1 74 ? -30.019 40.338 -20.681 1.00 92.93 ? 75 ALA A C 1 ATOM 581 O O . ALA A 1 74 ? -29.430 39.484 -20.007 1.00 97.17 ? 75 ALA A O 1 ATOM 582 C CB . ALA A 1 74 ? -28.389 42.240 -20.425 1.00 86.00 ? 75 ALA A CB 1 ATOM 583 N N . ALA A 1 75 ? -31.344 40.381 -20.825 1.00 88.06 ? 76 ALA A N 1 ATOM 584 C CA . ALA A 1 75 ? -32.252 39.456 -20.158 1.00 81.04 ? 76 ALA A CA 1 ATOM 585 C C . ALA A 1 75 ? -32.477 38.193 -21.002 1.00 84.03 ? 76 ALA A C 1 ATOM 586 O O . ALA A 1 75 ? -32.741 38.286 -22.207 1.00 91.92 ? 76 ALA A O 1 ATOM 587 C CB . ALA A 1 75 ? -33.572 40.155 -19.846 1.00 65.93 ? 76 ALA A CB 1 ATOM 588 N N . ILE A 1 76 ? -32.346 37.021 -20.377 1.00 76.38 ? 77 ILE A N 1 ATOM 589 C CA . ILE A 1 76 ? -32.724 35.761 -21.026 1.00 75.46 ? 77 ILE A CA 1 ATOM 590 C C . ILE A 1 76 ? -33.832 35.088 -20.218 1.00 79.91 ? 77 ILE A C 1 ATOM 591 O O . ILE A 1 76 ? -33.729 35.000 -18.993 1.00 82.67 ? 77 ILE A O 1 ATOM 592 C CB . ILE A 1 76 ? -31.551 34.753 -21.180 1.00 73.40 ? 77 ILE A CB 1 ATOM 593 C CG1 . ILE A 1 76 ? -30.146 35.416 -21.237 1.00 69.00 ? 77 ILE A CG1 1 ATOM 594 C CG2 . ILE A 1 76 ? -31.851 33.778 -22.315 1.00 67.75 ? 77 ILE A CG2 1 ATOM 595 C CD1 . ILE A 1 76 ? -29.795 36.184 -22.498 1.00 73.06 ? 77 ILE A CD1 1 ATOM 596 N N . SER A 1 77 ? -34.877 34.620 -20.910 1.00 77.53 ? 78 SER A N 1 ATOM 597 C CA . SER A 1 77 ? -36.026 33.926 -20.302 1.00 72.32 ? 78 SER A CA 1 ATOM 598 C C . SER A 1 77 ? -36.416 32.770 -21.224 1.00 72.57 ? 78 SER A C 1 ATOM 599 O O . SER A 1 77 ? -36.009 32.812 -22.351 1.00 88.22 ? 78 SER A O 1 ATOM 600 C CB . SER A 1 77 ? -37.168 34.915 -20.187 1.00 72.83 ? 78 SER A CB 1 ATOM 601 O OG . SER A 1 77 ? -36.819 35.972 -19.313 1.00 73.27 ? 78 SER A OG 1 ATOM 602 N N . GLY A 1 78 ? -37.155 31.732 -20.820 1.00 69.73 ? 79 GLY A N 1 ATOM 603 C CA . GLY A 1 78 ? -37.602 31.490 -19.473 1.00 69.36 ? 79 GLY A CA 1 ATOM 604 C C . GLY A 1 78 ? -38.731 30.509 -19.164 1.00 69.39 ? 79 GLY A C 1 ATOM 605 O O . GLY A 1 78 ? -39.489 30.821 -18.279 1.00 78.12 ? 79 GLY A O 1 ATOM 606 N N . TYR A 1 79 ? -38.853 29.340 -19.817 1.00 63.16 ? 80 TYR A N 1 ATOM 607 C CA . TYR A 1 79 ? -39.821 28.300 -19.335 1.00 61.88 ? 80 TYR A CA 1 ATOM 608 C C . TYR A 1 79 ? -39.194 27.043 -18.715 1.00 61.77 ? 80 TYR A C 1 ATOM 609 O O . TYR A 1 79 ? -38.146 26.593 -19.161 1.00 60.65 ? 80 TYR A O 1 ATOM 610 C CB . TYR A 1 79 ? -40.838 27.886 -20.405 1.00 62.95 ? 80 TYR A CB 1 ATOM 611 C CG . TYR A 1 79 ? -41.816 28.974 -20.803 1.00 67.48 ? 80 TYR A CG 1 ATOM 612 C CD1 . TYR A 1 79 ? -41.581 29.764 -21.946 1.00 72.31 ? 80 TYR A CD1 1 ATOM 613 C CD2 . TYR A 1 79 ? -42.981 29.223 -20.055 1.00 68.28 ? 80 TYR A CD2 1 ATOM 614 C CE1 . TYR A 1 79 ? -42.468 30.771 -22.329 1.00 72.51 ? 80 TYR A CE1 1 ATOM 615 C CE2 . TYR A 1 79 ? -43.877 30.237 -20.426 1.00 71.67 ? 80 TYR A CE2 1 ATOM 616 C CZ . TYR A 1 79 ? -43.612 31.004 -21.564 1.00 75.29 ? 80 TYR A CZ 1 ATOM 617 O OH . TYR A 1 79 ? -44.468 32.004 -21.954 1.00 76.53 ? 80 TYR A OH 1 ATOM 618 N N . SER A 1 80 ? -39.854 26.483 -17.693 1.00 65.56 ? 81 SER A N 1 ATOM 619 C CA . SER A 1 80 ? -39.363 25.299 -16.951 1.00 64.19 ? 81 SER A CA 1 ATOM 620 C C . SER A 1 80 ? -39.674 24.084 -17.750 1.00 59.62 ? 81 SER A C 1 ATOM 621 O O . SER A 1 80 ? -40.519 24.154 -18.613 1.00 70.84 ? 81 SER A O 1 ATOM 622 C CB . SER A 1 80 ? -40.094 25.142 -15.630 1.00 67.54 ? 81 SER A CB 1 ATOM 623 O OG . SER A 1 80 ? -41.237 24.327 -15.806 1.00 67.90 ? 81 SER A OG 1 ATOM 624 N N . PHE A 1 81 ? -39.053 22.958 -17.429 1.00 57.65 ? 82 PHE A N 1 ATOM 625 C CA . PHE A 1 81 ? -39.269 21.732 -18.201 1.00 55.71 ? 82 PHE A CA 1 ATOM 626 C C . PHE A 1 81 ? -40.410 20.870 -17.693 1.00 59.55 ? 82 PHE A C 1 ATOM 627 O O . PHE A 1 81 ? -40.591 19.747 -18.168 1.00 66.35 ? 82 PHE A O 1 ATOM 628 C CB . PHE A 1 81 ? -38.011 20.886 -18.243 1.00 53.27 ? 82 PHE A CB 1 ATOM 629 C CG . PHE A 1 81 ? -36.927 21.459 -19.082 1.00 63.62 ? 82 PHE A CG 1 ATOM 630 C CD1 . PHE A 1 81 ? -37.169 21.840 -20.402 1.00 66.30 ? 82 PHE A CD1 1 ATOM 631 C CD2 . PHE A 1 81 ? -35.628 21.603 -18.562 1.00 67.01 ? 82 PHE A CD2 1 ATOM 632 C CE1 . PHE A 1 81 ? -36.145 22.385 -21.173 1.00 68.85 ? 82 PHE A CE1 1 ATOM 633 C CE2 . PHE A 1 81 ? -34.599 22.140 -19.335 1.00 59.16 ? 82 PHE A CE2 1 ATOM 634 C CZ . PHE A 1 81 ? -34.862 22.536 -20.637 1.00 63.04 ? 82 PHE A CZ 1 ATOM 635 N N . LYS A 1 82 ? -41.180 21.374 -16.734 1.00 56.29 ? 83 LYS A N 1 ATOM 636 C CA . LYS A 1 82 ? -42.257 20.583 -16.140 1.00 55.36 ? 83 LYS A CA 1 ATOM 637 C C . LYS A 1 82 ? -43.264 20.160 -17.208 1.00 59.25 ? 83 LYS A C 1 ATOM 638 O O . LYS A 1 82 ? -43.806 19.050 -17.176 1.00 56.78 ? 83 LYS A O 1 ATOM 639 C CB . LYS A 1 82 ? -42.951 21.387 -15.044 1.00 56.98 ? 83 LYS A CB 1 ATOM 640 C CG . LYS A 1 82 ? -42.125 21.668 -13.798 1.00 54.21 ? 83 LYS A CG 1 ATOM 641 C CD . LYS A 1 82 ? -42.820 22.697 -12.938 1.00 53.07 ? 83 LYS A CD 1 ATOM 642 C CE . LYS A 1 82 ? -42.211 22.703 -11.548 1.00 57.22 ? 83 LYS A CE 1 ATOM 643 N NZ . LYS A 1 82 ? -40.994 23.553 -11.491 1.00 58.55 ? 83 LYS A NZ 1 ATOM 644 N N . GLN A 1 83 ? -43.451 21.051 -18.181 1.00 69.65 ? 84 GLN A N 1 ATOM 645 C CA . GLN A 1 83 ? -44.371 20.868 -19.306 1.00 86.94 ? 84 GLN A CA 1 ATOM 646 C C . GLN A 1 83 ? -43.874 19.869 -20.401 1.00 92.65 ? 84 GLN A C 1 ATOM 647 O O . GLN A 1 83 ? -44.598 19.596 -21.376 1.00 100.36 ? 84 GLN A O 1 ATOM 648 C CB . GLN A 1 83 ? -44.825 22.243 -19.889 1.00 90.74 ? 84 GLN A CB 1 ATOM 649 C CG . GLN A 1 83 ? -43.797 23.393 -19.904 1.00 89.12 ? 84 GLN A CG 1 ATOM 650 C CD . GLN A 1 83 ? -43.722 24.190 -18.589 1.00 90.23 ? 84 GLN A CD 1 ATOM 651 O OE1 . GLN A 1 83 ? -43.132 23.732 -17.620 1.00 107.88 ? 84 GLN A OE1 1 ATOM 652 N NE2 . GLN A 1 83 ? -44.289 25.391 -18.567 1.00 76.10 ? 84 GLN A NE2 1 ATOM 653 N N . CYS A 1 84 ? -42.673 19.304 -20.212 1.00 86.75 ? 85 CYS A N 1 ATOM 654 C CA . CYS A 1 84 ? -42.015 18.486 -21.237 1.00 81.71 ? 85 CYS A CA 1 ATOM 655 C C . CYS A 1 84 ? -42.000 16.981 -20.977 1.00 82.99 ? 85 CYS A C 1 ATOM 656 O O . CYS A 1 84 ? -41.955 16.507 -19.832 1.00 80.92 ? 85 CYS A O 1 ATOM 657 C CB . CYS A 1 84 ? -40.600 18.995 -21.528 1.00 81.26 ? 85 CYS A CB 1 ATOM 658 S SG . CYS A 1 84 ? -40.511 20.735 -22.027 1.00 100.57 ? 85 CYS A SG 1 ATOM 659 N N . SER A 1 85 ? -42.026 16.254 -22.088 1.00 85.75 ? 86 SER A N 1 ATOM 660 C CA . SER A 1 85 ? -42.111 14.802 -22.135 1.00 84.61 ? 86 SER A CA 1 ATOM 661 C C . SER A 1 85 ? -40.718 14.209 -22.188 1.00 94.07 ? 86 SER A C 1 ATOM 662 O O . SER A 1 85 ? -40.527 13.043 -21.830 1.00 102.74 ? 86 SER A O 1 ATOM 663 C CB . SER A 1 85 ? -42.857 14.404 -23.393 1.00 81.70 ? 86 SER A CB 1 ATOM 664 O OG . SER A 1 85 ? -43.562 15.522 -23.906 1.00 82.78 ? 86 SER A OG 1 ATOM 665 N N . HIS A 1 86 ? -39.765 15.025 -22.658 1.00 94.41 ? 87 HIS A N 1 ATOM 666 C CA . HIS A 1 86 ? -38.333 14.748 -22.631 1.00 85.09 ? 87 HIS A CA 1 ATOM 667 C C . HIS A 1 86 ? -37.902 14.423 -21.223 1.00 85.94 ? 87 HIS A C 1 ATOM 668 O O . HIS A 1 86 ? -38.449 14.961 -20.264 1.00 91.85 ? 87 HIS A O 1 ATOM 669 C CB . HIS A 1 86 ? -37.551 15.991 -23.058 1.00 93.00 ? 87 HIS A CB 1 ATOM 670 C CG . HIS A 1 86 ? -38.067 16.652 -24.300 1.00 117.38 ? 87 HIS A CG 1 ATOM 671 N ND1 . HIS A 1 86 ? -38.484 15.946 -25.412 1.00 133.48 ? 87 HIS A ND1 1 ATOM 672 C CD2 . HIS A 1 86 ? -38.196 17.961 -24.622 1.00 124.97 ? 87 HIS A CD2 1 ATOM 673 C CE1 . HIS A 1 86 ? -38.868 16.790 -26.354 1.00 134.03 ? 87 HIS A CE1 1 ATOM 674 N NE2 . HIS A 1 86 ? -38.700 18.020 -25.901 1.00 135.39 ? 87 HIS A NE2 1 ATOM 675 N N . GLN A 1 87 ? -36.910 13.557 -21.089 1.00 87.99 ? 88 GLN A N 1 ATOM 676 C CA . GLN A 1 87 ? -36.245 13.371 -19.802 1.00 92.33 ? 88 GLN A CA 1 ATOM 677 C C . GLN A 1 87 ? -35.391 14.612 -19.419 1.00 93.60 ? 88 GLN A C 1 ATOM 678 O O . GLN A 1 87 ? -35.045 15.438 -20.281 1.00 86.43 ? 88 GLN A O 1 ATOM 679 C CB . GLN A 1 87 ? -35.422 12.084 -19.832 1.00 92.76 ? 88 GLN A CB 1 ATOM 680 C CG . GLN A 1 87 ? -36.272 10.821 -19.915 1.00 95.81 ? 88 GLN A CG 1 ATOM 681 C CD . GLN A 1 87 ? -36.864 10.405 -18.574 1.00 103.31 ? 88 GLN A CD 1 ATOM 682 O OE1 . GLN A 1 87 ? -37.957 9.830 -18.508 1.00 103.88 ? 88 GLN A OE1 1 ATOM 683 N NE2 . GLN A 1 87 ? -36.136 10.684 -17.496 1.00 102.93 ? 88 GLN A NE2 1 ATOM 684 N N . ILE A 1 88 ? -35.092 14.762 -18.125 1.00 99.29 ? 89 ILE A N 1 ATOM 685 C CA . ILE A 1 88 ? -34.351 15.936 -17.605 1.00 98.86 ? 89 ILE A CA 1 ATOM 686 C C . ILE A 1 88 ? -33.379 15.536 -16.495 1.00 103.07 ? 89 ILE A C 1 ATOM 687 O O . ILE A 1 88 ? -33.751 14.753 -15.599 1.00 103.75 ? 89 ILE A O 1 ATOM 688 C CB . ILE A 1 88 ? -35.271 17.024 -16.986 1.00 96.47 ? 89 ILE A CB 1 ATOM 689 C CG1 . ILE A 1 88 ? -36.734 16.934 -17.485 1.00 85.78 ? 89 ILE A CG1 1 ATOM 690 C CG2 . ILE A 1 88 ? -34.650 18.393 -17.228 1.00 98.23 ? 89 ILE A CG2 1 ATOM 691 C CD1 . ILE A 1 88 ? -37.796 17.000 -16.405 1.00 63.95 ? 89 ILE A CD1 1 ATOM 692 N N . SER A 1 89 ? -32.154 16.079 -16.549 1.00 96.55 ? 90 SER A N 1 ATOM 693 C CA . SER A 1 89 ? -31.168 15.907 -15.458 1.00 89.35 ? 90 SER A CA 1 ATOM 694 C C . SER A 1 89 ? -30.648 17.236 -14.915 1.00 82.90 ? 90 SER A C 1 ATOM 695 O O . SER A 1 89 ? -30.685 18.263 -15.610 1.00 75.72 ? 90 SER A O 1 ATOM 696 C CB . SER A 1 89 ? -30.005 14.980 -15.860 1.00 89.74 ? 90 SER A CB 1 ATOM 697 O OG . SER A 1 89 ? -29.129 15.591 -16.788 1.00 94.93 ? 90 SER A OG 1 ATOM 698 N N . ALA A 1 90 ? -30.179 17.203 -13.667 1.00 79.81 ? 91 ALA A N 1 ATOM 699 C CA . ALA A 1 90 ? -29.571 18.376 -13.014 1.00 84.46 ? 91 ALA A CA 1 ATOM 700 C C . ALA A 1 90 ? -28.029 18.412 -13.163 1.00 84.92 ? 91 ALA A C 1 ATOM 701 O O . ALA A 1 90 ? -27.346 19.273 -12.591 1.00 89.79 ? 91 ALA A O 1 ATOM 702 C CB . ALA A 1 90 ? -30.000 18.453 -11.548 1.00 76.65 ? 91 ALA A CB 1 ATOM 703 N N . CYS A 1 91 ? -27.514 17.479 -13.961 1.00 81.51 ? 92 CYS A N 1 ATOM 704 C CA . CYS A 1 91 ? -26.106 17.312 -14.212 1.00 79.90 ? 92 CYS A CA 1 ATOM 705 C C . CYS A 1 91 ? -25.565 18.454 -15.065 1.00 79.95 ? 92 CYS A C 1 ATOM 706 O O . CYS A 1 91 ? -26.002 18.643 -16.187 1.00 92.33 ? 92 CYS A O 1 ATOM 707 C CB . CYS A 1 91 ? -25.896 15.996 -14.947 1.00 85.07 ? 92 CYS A CB 1 ATOM 708 S SG . CYS A 1 91 ? -24.173 15.758 -15.441 1.00 98.30 ? 92 CYS A SG 1 ATOM 709 N N . ASN A 1 92 ? -24.595 19.189 -14.534 1.00 74.66 ? 93 ASN A N 1 ATOM 710 C CA . ASN A 1 92 ? -24.032 20.365 -15.195 1.00 70.05 ? 93 ASN A CA 1 ATOM 711 C C . ASN A 1 92 ? -22.514 20.280 -15.195 1.00 68.37 ? 93 ASN A C 1 ATOM 712 O O . ASN A 1 92 ? -21.835 20.677 -14.238 1.00 73.39 ? 93 ASN A O 1 ATOM 713 C CB . ASN A 1 92 ? -24.548 21.662 -14.526 1.00 70.89 ? 93 ASN A CB 1 ATOM 714 C CG . ASN A 1 92 ? -23.938 22.940 -15.111 1.00 69.19 ? 93 ASN A CG 1 ATOM 715 O OD1 . ASN A 1 92 ? -23.611 23.018 -16.289 1.00 71.85 ? 93 ASN A OD1 1 ATOM 716 N ND2 . ASN A 1 92 ? -23.805 23.956 -14.273 1.00 67.29 ? 93 ASN A ND2 1 ATOM 717 N N . LYS A 1 93 ? -21.992 19.749 -16.289 1.00 67.34 ? 94 LYS A N 1 ATOM 718 C CA . LYS A 1 93 ? -20.565 19.526 -16.436 1.00 62.95 ? 94 LYS A CA 1 ATOM 719 C C . LYS A 1 93 ? -19.734 20.808 -16.760 1.00 68.39 ? 94 LYS A C 1 ATOM 720 O O . LYS A 1 93 ? -18.480 20.773 -16.685 1.00 69.79 ? 94 LYS A O 1 ATOM 721 C CB . LYS A 1 93 ? -20.330 18.406 -17.451 1.00 58.10 ? 94 LYS A CB 1 ATOM 722 C CG . LYS A 1 93 ? -20.417 17.007 -16.862 1.00 55.82 ? 94 LYS A CG 1 ATOM 723 C CD . LYS A 1 93 ? -20.540 15.949 -17.960 1.00 59.73 ? 94 LYS A CD 1 ATOM 724 C CE . LYS A 1 93 ? -20.338 14.528 -17.431 1.00 68.47 ? 94 LYS A CE 1 ATOM 725 N NZ . LYS A 1 93 ? -20.869 13.415 -18.301 1.00 79.82 ? 94 LYS A NZ 1 ATOM 726 N N . ASP A 1 94 ? -20.421 21.920 -17.072 1.00 60.11 ? 95 ASP A N 1 ATOM 727 C CA . ASP A 1 94 ? -19.788 23.225 -17.332 1.00 59.74 ? 95 ASP A CA 1 ATOM 728 C C . ASP A 1 94 ? -18.751 23.675 -16.281 1.00 59.70 ? 95 ASP A C 1 ATOM 729 O O . ASP A 1 94 ? -19.002 23.626 -15.078 1.00 63.91 ? 95 ASP A O 1 ATOM 730 C CB . ASP A 1 94 ? -20.860 24.299 -17.529 1.00 63.51 ? 95 ASP A CB 1 ATOM 731 C CG . ASP A 1 94 ? -21.526 24.240 -18.929 1.00 78.24 ? 95 ASP A CG 1 ATOM 732 O OD1 . ASP A 1 94 ? -20.978 24.805 -19.895 1.00 81.74 ? 95 ASP A OD1 1 ATOM 733 O OD2 . ASP A 1 94 ? -22.618 23.651 -19.084 1.00 86.05 ? 95 ASP A OD2 1 ATOM 734 N N . ILE A 1 95 ? -17.565 24.053 -16.755 1.00 63.09 ? 96 ILE A N 1 ATOM 735 C CA . ILE A 1 95 ? -16.563 24.780 -15.945 1.00 65.72 ? 96 ILE A CA 1 ATOM 736 C C . ILE A 1 95 ? -16.616 26.250 -16.364 1.00 67.51 ? 96 ILE A C 1 ATOM 737 O O . ILE A 1 95 ? -16.618 26.561 -17.556 1.00 76.85 ? 96 ILE A O 1 ATOM 738 C CB . ILE A 1 95 ? -15.107 24.252 -16.124 1.00 64.14 ? 96 ILE A CB 1 ATOM 739 C CG1 . ILE A 1 95 ? -14.956 22.780 -15.683 1.00 62.13 ? 96 ILE A CG1 1 ATOM 740 C CG2 . ILE A 1 95 ? -14.097 25.148 -15.397 1.00 66.49 ? 96 ILE A CG2 1 ATOM 741 C CD1 . ILE A 1 95 ? -14.884 22.511 -14.189 1.00 55.72 ? 96 ILE A CD1 1 ATOM 742 N N . TYR A 1 96 ? -16.639 27.137 -15.375 1.00 63.96 ? 97 TYR A N 1 ATOM 743 C CA . TYR A 1 96 ? -16.952 28.539 -15.579 1.00 61.32 ? 97 TYR A CA 1 ATOM 744 C C . TYR A 1 96 ? -15.726 29.385 -15.313 1.00 62.49 ? 97 TYR A C 1 ATOM 745 O O . TYR A 1 96 ? -15.287 29.555 -14.166 1.00 64.20 ? 97 TYR A O 1 ATOM 746 C CB . TYR A 1 96 ? -18.141 28.948 -14.699 1.00 65.43 ? 97 TYR A CB 1 ATOM 747 C CG . TYR A 1 96 ? -19.455 28.293 -15.094 1.00 66.92 ? 97 TYR A CG 1 ATOM 748 C CD1 . TYR A 1 96 ? -20.294 28.891 -16.037 1.00 67.27 ? 97 TYR A CD1 1 ATOM 749 C CD2 . TYR A 1 96 ? -19.861 27.076 -14.525 1.00 66.39 ? 97 TYR A CD2 1 ATOM 750 C CE1 . TYR A 1 96 ? -21.487 28.291 -16.419 1.00 71.86 ? 97 TYR A CE1 1 ATOM 751 C CE2 . TYR A 1 96 ? -21.059 26.468 -14.897 1.00 71.14 ? 97 TYR A CE2 1 ATOM 752 C CZ . TYR A 1 96 ? -21.875 27.081 -15.843 1.00 76.40 ? 97 TYR A CZ 1 ATOM 753 O OH . TYR A 1 96 ? -23.076 26.501 -16.234 1.00 81.63 ? 97 TYR A OH 1 ATOM 754 N N . VAL A 1 97 ? -15.185 29.904 -16.410 1.00 64.14 ? 98 VAL A N 1 ATOM 755 C CA . VAL A 1 97 ? -13.896 30.580 -16.443 1.00 64.24 ? 98 VAL A CA 1 ATOM 756 C C . VAL A 1 97 ? -14.090 32.049 -16.123 1.00 67.16 ? 98 VAL A C 1 ATOM 757 O O . VAL A 1 97 ? -15.094 32.633 -16.526 1.00 70.27 ? 98 VAL A O 1 ATOM 758 C CB . VAL A 1 97 ? -13.233 30.394 -17.816 1.00 60.85 ? 98 VAL A CB 1 ATOM 759 C CG1 . VAL A 1 97 ? -11.846 31.021 -17.850 1.00 61.89 ? 98 VAL A CG1 1 ATOM 760 C CG2 . VAL A 1 97 ? -13.132 28.907 -18.122 1.00 62.00 ? 98 VAL A CG2 1 ATOM 761 N N . ASP A 1 98 ? -13.111 32.613 -15.400 1.00 73.72 ? 99 ASP A N 1 ATOM 762 C CA . ASP A 1 98 ? -13.098 33.987 -14.858 1.00 79.10 ? 99 ASP A CA 1 ATOM 763 C C . ASP A 1 98 ? -14.316 34.271 -14.001 1.00 82.27 ? 99 ASP A C 1 ATOM 764 O O . ASP A 1 98 ? -14.816 35.405 -13.962 1.00 89.79 ? 99 ASP A O 1 ATOM 765 C CB . ASP A 1 98 ? -12.969 35.054 -15.959 1.00 91.32 ? 99 ASP A CB 1 ATOM 766 C CG . ASP A 1 98 ? -11.689 34.940 -16.741 1.00 98.27 ? 99 ASP A CG 1 ATOM 767 O OD1 . ASP A 1 98 ? -10.636 34.593 -16.151 1.00 98.45 ? 99 ASP A OD1 1 ATOM 768 O OD2 . ASP A 1 98 ? -11.752 35.210 -17.962 1.00 110.72 ? 99 ASP A OD2 1 ATOM 769 N N . LEU A 1 99 ? -14.787 33.236 -13.314 1.00 75.87 ? 100 LEU A N 1 ATOM 770 C CA . LEU A 1 99 ? -16.022 33.323 -12.585 1.00 68.06 ? 100 LEU A CA 1 ATOM 771 C C . LEU A 1 99 ? -15.833 32.780 -11.181 1.00 69.37 ? 100 LEU A C 1 ATOM 772 O O . LEU A 1 99 ? -15.357 31.649 -11.020 1.00 71.65 ? 100 LEU A O 1 ATOM 773 C CB . LEU A 1 99 ? -17.088 32.565 -13.365 1.00 64.57 ? 100 LEU A CB 1 ATOM 774 C CG . LEU A 1 99 ? -18.515 33.100 -13.221 1.00 69.19 ? 100 LEU A CG 1 ATOM 775 C CD1 . LEU A 1 99 ? -18.610 34.588 -13.510 1.00 70.89 ? 100 LEU A CD1 1 ATOM 776 C CD2 . LEU A 1 99 ? -19.474 32.348 -14.127 1.00 72.68 ? 100 LEU A CD2 1 ATOM 777 N N . ASP A 1 100 ? -16.151 33.603 -10.176 1.00 65.94 ? 101 ASP A N 1 ATOM 778 C CA . ASP A 1 100 ? -16.095 33.183 -8.761 1.00 67.98 ? 101 ASP A CA 1 ATOM 779 C C . ASP A 1 100 ? -17.494 33.074 -8.168 1.00 68.25 ? 101 ASP A C 1 ATOM 780 O O . ASP A 1 100 ? -18.227 34.075 -8.037 1.00 60.91 ? 101 ASP A O 1 ATOM 781 C CB . ASP A 1 100 ? -15.228 34.124 -7.902 1.00 74.30 ? 101 ASP A CB 1 ATOM 782 C CG . ASP A 1 100 ? -15.133 33.687 -6.416 1.00 88.65 ? 101 ASP A CG 1 ATOM 783 O OD1 . ASP A 1 100 ? -15.506 32.547 -6.073 1.00 109.80 ? 101 ASP A OD1 1 ATOM 784 O OD2 . ASP A 1 100 ? -14.658 34.476 -5.569 1.00 90.68 ? 101 ASP A OD2 1 ATOM 785 N N . MET A 1 101 ? -17.842 31.849 -7.783 1.00 68.71 ? 102 MET A N 1 ATOM 786 C CA . MET A 1 101 ? -19.155 31.577 -7.206 1.00 70.58 ? 102 MET A CA 1 ATOM 787 C C . MET A 1 101 ? -19.069 31.461 -5.681 1.00 71.94 ? 102 MET A C 1 ATOM 788 O O . MET A 1 101 ? -18.331 30.598 -5.166 1.00 65.76 ? 102 MET A O 1 ATOM 789 C CB . MET A 1 101 ? -19.738 30.309 -7.802 1.00 66.92 ? 102 MET A CB 1 ATOM 790 C CG . MET A 1 101 ? -19.881 30.321 -9.302 1.00 63.69 ? 102 MET A CG 1 ATOM 791 S SD . MET A 1 101 ? -20.940 28.944 -9.757 1.00 78.57 ? 102 MET A SD 1 ATOM 792 C CE . MET A 1 101 ? -20.003 27.460 -9.355 1.00 68.14 ? 102 MET A CE 1 ATOM 793 N N . LYS A 1 102 ? -19.838 32.306 -4.977 1.00 68.13 ? 103 LYS A N 1 ATOM 794 C CA . LYS A 1 102 ? -19.680 32.487 -3.522 1.00 72.10 ? 103 LYS A CA 1 ATOM 795 C C . LYS A 1 102 ? -20.577 31.637 -2.627 1.00 73.06 ? 103 LYS A C 1 ATOM 796 O O . LYS A 1 102 ? -21.756 31.435 -2.922 1.00 71.87 ? 103 LYS A O 1 ATOM 797 C CB . LYS A 1 102 ? -19.840 33.955 -3.129 1.00 70.86 ? 103 LYS A CB 1 ATOM 798 C CG . LYS A 1 102 ? -19.040 34.932 -3.969 1.00 80.93 ? 103 LYS A CG 1 ATOM 799 C CD . LYS A 1 102 ? -17.540 34.883 -3.717 1.00 81.01 ? 103 LYS A CD 1 ATOM 800 C CE . LYS A 1 102 ? -16.880 36.090 -4.361 1.00 81.33 ? 103 LYS A CE 1 ATOM 801 N NZ . LYS A 1 102 ? -15.551 36.383 -3.765 1.00 86.61 ? 103 LYS A NZ 1 ATOM 802 N N . GLY A 1 103 ? -19.984 31.161 -1.529 1.00 72.43 ? 104 GLY A N 1 ATOM 803 C CA . GLY A 1 103 ? -20.681 30.443 -0.448 1.00 70.02 ? 104 GLY A CA 1 ATOM 804 C C . GLY A 1 103 ? -19.762 30.139 0.726 1.00 65.02 ? 104 GLY A C 1 ATOM 805 O O . GLY A 1 103 ? -18.622 30.583 0.740 1.00 76.41 ? 104 GLY A O 1 ATOM 806 N N . ILE A 1 104 ? -20.247 29.370 1.695 1.00 59.97 ? 105 ILE A N 1 ATOM 807 C CA . ILE A 1 104 ? -19.484 29.004 2.905 1.00 64.35 ? 105 ILE A CA 1 ATOM 808 C C . ILE A 1 104 ? -18.212 28.213 2.528 1.00 67.21 ? 105 ILE A C 1 ATOM 809 O O . ILE A 1 104 ? -18.292 27.074 2.059 1.00 72.28 ? 105 ILE A O 1 ATOM 810 C CB . ILE A 1 104 ? -20.403 28.225 3.923 1.00 67.83 ? 105 ILE A CB 1 ATOM 811 C CG1 . ILE A 1 104 ? -21.661 29.034 4.333 1.00 67.57 ? 105 ILE A CG1 1 ATOM 812 C CG2 . ILE A 1 104 ? -19.646 27.683 5.142 1.00 66.34 ? 105 ILE A CG2 1 ATOM 813 C CD1 . ILE A 1 104 ? -21.449 30.494 4.727 1.00 72.53 ? 105 ILE A CD1 1 ATOM 814 N N . ASN A 1 105 ? -17.042 28.819 2.693 1.00 67.07 ? 106 ASN A N 1 ATOM 815 C CA . ASN A 1 105 ? -15.810 28.152 2.252 1.00 72.95 ? 106 ASN A CA 1 ATOM 816 C C . ASN A 1 105 ? -15.288 27.239 3.355 1.00 71.09 ? 106 ASN A C 1 ATOM 817 O O . ASN A 1 105 ? -15.004 27.711 4.450 1.00 73.27 ? 106 ASN A O 1 ATOM 818 C CB . ASN A 1 105 ? -14.746 29.161 1.817 1.00 83.32 ? 106 ASN A CB 1 ATOM 819 C CG . ASN A 1 105 ? -15.307 30.278 0.945 1.00 100.15 ? 106 ASN A CG 1 ATOM 820 O OD1 . ASN A 1 105 ? -15.644 30.073 -0.223 1.00 107.86 ? 106 ASN A OD1 1 ATOM 821 N ND2 . ASN A 1 105 ? -15.402 31.475 1.516 1.00 111.03 ? 106 ASN A ND2 1 ATOM 822 N N . TYR A 1 106 ? -15.159 25.940 3.081 1.00 67.39 ? 107 TYR A N 1 ATOM 823 C CA . TYR A 1 106 ? -14.945 24.988 4.173 1.00 64.73 ? 107 TYR A CA 1 ATOM 824 C C . TYR A 1 106 ? -13.731 24.025 4.098 1.00 71.67 ? 107 TYR A C 1 ATOM 825 O O . TYR A 1 106 ? -13.277 23.581 5.144 1.00 84.16 ? 107 TYR A O 1 ATOM 826 C CB . TYR A 1 106 ? -16.263 24.260 4.529 1.00 60.05 ? 107 TYR A CB 1 ATOM 827 C CG . TYR A 1 106 ? -16.612 23.193 3.553 1.00 57.64 ? 107 TYR A CG 1 ATOM 828 C CD1 . TYR A 1 106 ? -16.124 21.899 3.712 1.00 54.67 ? 107 TYR A CD1 1 ATOM 829 C CD2 . TYR A 1 106 ? -17.389 23.484 2.427 1.00 62.98 ? 107 TYR A CD2 1 ATOM 830 C CE1 . TYR A 1 106 ? -16.409 20.915 2.785 1.00 59.23 ? 107 TYR A CE1 1 ATOM 831 C CE2 . TYR A 1 106 ? -17.692 22.504 1.494 1.00 63.11 ? 107 TYR A CE2 1 ATOM 832 C CZ . TYR A 1 106 ? -17.190 21.227 1.680 1.00 65.27 ? 107 TYR A CZ 1 ATOM 833 O OH . TYR A 1 106 ? -17.464 20.252 0.760 1.00 80.75 ? 107 TYR A OH 1 ATOM 834 N N . ASN A 1 107 ? -13.232 23.657 2.915 1.00 68.07 ? 108 ASN A N 1 ATOM 835 C CA . ASN A 1 107 ? -11.886 23.031 2.819 1.00 71.36 ? 108 ASN A CA 1 ATOM 836 C C . ASN A 1 107 ? -11.152 24.001 1.938 1.00 73.81 ? 108 ASN A C 1 ATOM 837 O O . ASN A 1 107 ? -11.767 24.636 1.084 1.00 77.70 ? 108 ASN A O 1 ATOM 838 C CB . ASN A 1 107 ? -11.894 21.608 2.186 1.00 75.22 ? 108 ASN A CB 1 ATOM 839 C CG . ASN A 1 107 ? -10.896 20.610 2.839 1.00 74.32 ? 108 ASN A CG 1 ATOM 840 O OD1 . ASN A 1 107 ? -10.685 20.631 4.057 1.00 77.95 ? 108 ASN A OD1 1 ATOM 841 N ND2 . ASN A 1 107 ? -10.299 19.699 2.001 1.00 77.32 ? 108 ASN A ND2 1 ATOM 842 N N . SER A 1 108 ? -9.857 24.159 2.163 1.00 77.38 ? 109 SER A N 1 ATOM 843 C CA . SER A 1 108 ? -9.048 24.990 1.289 1.00 81.74 ? 109 SER A CA 1 ATOM 844 C C . SER A 1 108 ? -7.701 24.334 0.989 1.00 87.63 ? 109 SER A C 1 ATOM 845 O O . SER A 1 108 ? -6.631 24.890 1.255 1.00 110.47 ? 109 SER A O 1 ATOM 846 C CB . SER A 1 108 ? -8.898 26.391 1.853 1.00 76.23 ? 109 SER A CB 1 ATOM 847 O OG . SER A 1 108 ? -8.164 27.175 0.942 1.00 85.19 ? 109 SER A OG 1 ATOM 848 N N . SER A 1 109 ? -7.796 23.134 0.434 1.00 85.97 ? 110 SER A N 1 ATOM 849 C CA . SER A 1 109 ? -6.685 22.354 -0.083 1.00 88.06 ? 110 SER A CA 1 ATOM 850 C C . SER A 1 109 ? -6.097 22.942 -1.387 1.00 94.06 ? 110 SER A C 1 ATOM 851 O O . SER A 1 109 ? -6.569 23.976 -1.885 1.00 96.49 ? 110 SER A O 1 ATOM 852 C CB . SER A 1 109 ? -7.207 20.949 -0.352 1.00 98.19 ? 110 SER A CB 1 ATOM 853 O OG . SER A 1 109 ? -8.422 21.005 -1.103 1.00 109.05 ? 110 SER A OG 1 ATOM 854 N N . VAL A 1 110 ? -5.081 22.259 -1.927 1.00 87.80 ? 111 VAL A N 1 ATOM 855 C CA . VAL A 1 110 ? -4.306 22.671 -3.118 1.00 85.24 ? 111 VAL A CA 1 ATOM 856 C C . VAL A 1 110 ? -4.382 21.570 -4.195 1.00 81.50 ? 111 VAL A C 1 ATOM 857 O O . VAL A 1 110 ? -4.279 20.392 -3.861 1.00 82.65 ? 111 VAL A O 1 ATOM 858 C CB . VAL A 1 110 ? -2.830 22.972 -2.719 1.00 92.77 ? 111 VAL A CB 1 ATOM 859 C CG1 . VAL A 1 110 ? -2.324 21.996 -1.657 1.00 102.02 ? 111 VAL A CG1 1 ATOM 860 C CG2 . VAL A 1 110 ? -1.883 22.982 -3.916 1.00 88.01 ? 111 VAL A CG2 1 ATOM 861 N N . ALA A 1 111 ? -4.538 21.939 -5.473 1.00 74.58 ? 112 ALA A N 1 ATOM 862 C CA . ALA A 1 111 ? -4.868 20.946 -6.512 1.00 72.71 ? 112 ALA A CA 1 ATOM 863 C C . ALA A 1 111 ? -4.163 21.064 -7.869 1.00 72.86 ? 112 ALA A C 1 ATOM 864 O O . ALA A 1 111 ? -3.918 22.177 -8.345 1.00 68.96 ? 112 ALA A O 1 ATOM 865 C CB . ALA A 1 111 ? -6.378 20.909 -6.716 1.00 79.57 ? 112 ALA A CB 1 ATOM 866 N N . LYS A 1 112 ? -3.882 19.898 -8.476 1.00 74.46 ? 113 LYS A N 1 ATOM 867 C CA . LYS A 1 112 ? -3.312 19.728 -9.838 1.00 74.27 ? 113 LYS A CA 1 ATOM 868 C C . LYS A 1 112 ? -3.963 20.542 -10.951 1.00 74.85 ? 113 LYS A C 1 ATOM 869 O O . LYS A 1 112 ? -3.270 21.060 -11.810 1.00 79.11 ? 113 LYS A O 1 ATOM 870 C CB . LYS A 1 112 ? -3.424 18.262 -10.293 1.00 81.89 ? 113 LYS A CB 1 ATOM 871 C CG . LYS A 1 112 ? -2.271 17.344 -9.941 1.00 93.75 ? 113 LYS A CG 1 ATOM 872 C CD . LYS A 1 112 ? -2.485 15.920 -10.474 1.00 94.63 ? 113 LYS A CD 1 ATOM 873 C CE . LYS A 1 112 ? -1.171 15.131 -10.538 1.00 100.32 ? 113 LYS A CE 1 ATOM 874 N NZ . LYS A 1 112 ? -0.329 15.172 -9.294 1.00 96.91 ? 113 LYS A NZ 1 ATOM 875 N N . SER A 1 113 ? -5.295 20.604 -10.958 1.00 79.07 ? 114 SER A N 1 ATOM 876 C CA . SER A 1 113 ? -6.073 21.075 -12.112 1.00 74.81 ? 114 SER A CA 1 ATOM 877 C C . SER A 1 113 ? -7.488 21.413 -11.691 1.00 71.33 ? 114 SER A C 1 ATOM 878 O O . SER A 1 113 ? -7.951 21.006 -10.619 1.00 69.83 ? 114 SER A O 1 ATOM 879 C CB . SER A 1 113 ? -6.128 19.983 -13.211 1.00 82.99 ? 114 SER A CB 1 ATOM 880 O OG . SER A 1 113 ? -6.584 18.708 -12.725 1.00 78.08 ? 114 SER A OG 1 ATOM 881 N N . ALA A 1 114 ? -8.187 22.135 -12.554 1.00 65.03 ? 115 ALA A N 1 ATOM 882 C CA . ALA A 1 114 ? -9.624 22.258 -12.429 1.00 63.32 ? 115 ALA A CA 1 ATOM 883 C C . ALA A 1 114 ? -10.302 20.889 -12.276 1.00 65.84 ? 115 ALA A C 1 ATOM 884 O O . ALA A 1 114 ? -11.170 20.709 -11.414 1.00 69.91 ? 115 ALA A O 1 ATOM 885 C CB . ALA A 1 114 ? -10.179 22.997 -13.618 1.00 59.74 ? 115 ALA A CB 1 ATOM 886 N N . GLN A 1 115 ? -9.882 19.926 -13.093 1.00 69.14 ? 116 GLN A N 1 ATOM 887 C CA . GLN A 1 115 ? -10.467 18.584 -13.081 1.00 71.99 ? 116 GLN A CA 1 ATOM 888 C C . GLN A 1 115 ? -10.383 17.898 -11.727 1.00 71.19 ? 116 GLN A C 1 ATOM 889 O O . GLN A 1 115 ? -11.407 17.473 -11.210 1.00 82.12 ? 116 GLN A O 1 ATOM 890 C CB . GLN A 1 115 ? -9.869 17.695 -14.171 1.00 79.61 ? 116 GLN A CB 1 ATOM 891 C CG . GLN A 1 115 ? -10.722 16.480 -14.506 1.00 83.08 ? 116 GLN A CG 1 ATOM 892 C CD . GLN A 1 115 ? -10.052 15.520 -15.472 1.00 88.94 ? 116 GLN A CD 1 ATOM 893 O OE1 . GLN A 1 115 ? -9.445 14.533 -15.058 1.00 96.57 ? 116 GLN A OE1 1 ATOM 894 N NE2 . GLN A 1 115 ? -10.159 15.806 -16.767 1.00 93.32 ? 116 GLN A NE2 1 ATOM 895 N N . GLU A 1 116 ? -9.187 17.809 -11.151 1.00 72.18 ? 117 GLU A N 1 ATOM 896 C CA . GLU A 1 116 ? -8.997 17.182 -9.831 1.00 78.79 ? 117 GLU A CA 1 ATOM 897 C C . GLU A 1 116 ? -9.706 17.918 -8.668 1.00 83.53 ? 117 GLU A C 1 ATOM 898 O O . GLU A 1 116 ? -10.005 17.322 -7.615 1.00 80.07 ? 117 GLU A O 1 ATOM 899 C CB . GLU A 1 116 ? -7.514 17.068 -9.536 1.00 88.66 ? 117 GLU A CB 1 ATOM 900 C CG . GLU A 1 116 ? -7.205 16.385 -8.221 1.00 99.43 ? 117 GLU A CG 1 ATOM 901 C CD . GLU A 1 116 ? -5.806 16.670 -7.781 1.00 113.11 ? 117 GLU A CD 1 ATOM 902 O OE1 . GLU A 1 116 ? -4.897 15.959 -8.254 1.00 127.71 ? 117 GLU A OE1 1 ATOM 903 O OE2 . GLU A 1 116 ? -5.618 17.609 -6.982 1.00 120.12 ? 117 GLU A OE2 1 ATOM 904 N N . CYS A 1 117 ? -9.942 19.215 -8.864 1.00 79.48 ? 118 CYS A N 1 ATOM 905 C CA . CYS A 1 117 ? -10.713 20.016 -7.943 1.00 71.65 ? 118 CYS A CA 1 ATOM 906 C C . CYS A 1 117 ? -12.188 19.581 -8.015 1.00 75.37 ? 118 CYS A C 1 ATOM 907 O O . CYS A 1 117 ? -12.807 19.312 -6.971 1.00 77.36 ? 118 CYS A O 1 ATOM 908 C CB . CYS A 1 117 ? -10.523 21.502 -8.270 1.00 68.10 ? 118 CYS A CB 1 ATOM 909 S SG . CYS A 1 117 ? -11.263 22.670 -7.094 1.00 77.35 ? 118 CYS A SG 1 ATOM 910 N N . GLN A 1 118 ? -12.726 19.482 -9.242 1.00 68.61 ? 119 GLN A N 1 ATOM 911 C CA . GLN A 1 118 ? -14.100 19.031 -9.483 1.00 61.31 ? 119 GLN A CA 1 ATOM 912 C C . GLN A 1 118 ? -14.335 17.642 -8.902 1.00 61.87 ? 119 GLN A C 1 ATOM 913 O O . GLN A 1 118 ? -15.348 17.392 -8.260 1.00 59.05 ? 119 GLN A O 1 ATOM 914 C CB . GLN A 1 118 ? -14.408 19.028 -10.976 1.00 59.29 ? 119 GLN A CB 1 ATOM 915 C CG . GLN A 1 118 ? -15.847 18.654 -11.284 1.00 61.84 ? 119 GLN A CG 1 ATOM 916 C CD . GLN A 1 118 ? -16.303 19.133 -12.646 1.00 71.57 ? 119 GLN A CD 1 ATOM 917 O OE1 . GLN A 1 118 ? -15.673 18.807 -13.658 1.00 73.61 ? 119 GLN A OE1 1 ATOM 918 N NE2 . GLN A 1 118 ? -17.418 19.905 -12.688 1.00 66.62 ? 119 GLN A NE2 1 ATOM 919 N N . GLU A 1 119 ? -13.373 16.756 -9.133 1.00 63.31 ? 120 GLU A N 1 ATOM 920 C CA . GLU A 1 119 ? -13.390 15.411 -8.605 1.00 65.68 ? 120 GLU A CA 1 ATOM 921 C C . GLU A 1 119 ? -13.473 15.391 -7.086 1.00 68.95 ? 120 GLU A C 1 ATOM 922 O O . GLU A 1 119 ? -14.244 14.608 -6.521 1.00 70.07 ? 120 GLU A O 1 ATOM 923 C CB . GLU A 1 119 ? -12.180 14.639 -9.109 1.00 73.39 ? 120 GLU A CB 1 ATOM 924 C CG . GLU A 1 119 ? -12.365 14.154 -10.540 1.00 87.93 ? 120 GLU A CG 1 ATOM 925 C CD . GLU A 1 119 ? -11.066 13.894 -11.286 1.00 101.17 ? 120 GLU A CD 1 ATOM 926 O OE1 . GLU A 1 119 ? -11.100 13.980 -12.538 1.00 100.09 ? 120 GLU A OE1 1 ATOM 927 O OE2 . GLU A 1 119 ? -10.026 13.603 -10.639 1.00 103.99 ? 120 GLU A OE2 1 ATOM 928 N N . ARG A 1 120 ? -12.712 16.273 -6.432 1.00 73.11 ? 121 ARG A N 1 ATOM 929 C CA . ARG A 1 120 ? -12.739 16.394 -4.974 1.00 74.17 ? 121 ARG A CA 1 ATOM 930 C C . ARG A 1 120 ? -14.127 16.840 -4.485 1.00 73.10 ? 121 ARG A C 1 ATOM 931 O O . ARG A 1 120 ? -14.703 16.231 -3.568 1.00 71.11 ? 121 ARG A O 1 ATOM 932 C CB . ARG A 1 120 ? -11.642 17.342 -4.495 1.00 80.59 ? 121 ARG A CB 1 ATOM 933 C CG . ARG A 1 120 ? -11.308 17.185 -3.016 1.00 92.46 ? 121 ARG A CG 1 ATOM 934 C CD . ARG A 1 120 ? -10.114 18.037 -2.627 1.00 93.37 ? 121 ARG A CD 1 ATOM 935 N NE . ARG A 1 120 ? -8.884 17.516 -3.222 1.00 92.90 ? 121 ARG A NE 1 ATOM 936 C CZ . ARG A 1 120 ? -7.789 18.228 -3.487 1.00 96.95 ? 121 ARG A CZ 1 ATOM 937 N NH1 . ARG A 1 120 ? -7.724 19.537 -3.236 1.00 97.84 ? 121 ARG A NH1 1 ATOM 938 N NH2 . ARG A 1 120 ? -6.746 17.616 -4.027 1.00 107.08 ? 121 ARG A NH2 1 ATOM 939 N N . CYS A 1 121 ? -14.657 17.881 -5.133 1.00 69.69 ? 122 CYS A N 1 ATOM 940 C CA . CYS A 1 121 ? -15.993 18.399 -4.866 1.00 61.44 ? 122 CYS A CA 1 ATOM 941 C C . CYS A 1 121 ? -17.070 17.324 -4.994 1.00 59.56 ? 122 CYS A C 1 ATOM 942 O O . CYS A 1 121 ? -17.986 17.239 -4.174 1.00 57.12 ? 122 CYS A O 1 ATOM 943 C CB . CYS A 1 121 ? -16.308 19.546 -5.817 1.00 60.41 ? 122 CYS A CB 1 ATOM 944 S SG . CYS A 1 121 ? -17.935 20.223 -5.486 1.00 67.41 ? 122 CYS A SG 1 ATOM 945 N N . THR A 1 122 ? -16.954 16.510 -6.038 1.00 59.75 ? 123 THR A N 1 ATOM 946 C CA . THR A 1 122 ? -17.946 15.490 -6.327 1.00 62.16 ? 123 THR A CA 1 ATOM 947 C C . THR A 1 122 ? -17.865 14.397 -5.281 1.00 63.49 ? 123 THR A C 1 ATOM 948 O O . THR A 1 122 ? -18.897 13.822 -4.916 1.00 61.86 ? 123 THR A O 1 ATOM 949 C CB . THR A 1 122 ? -17.739 14.878 -7.715 1.00 64.48 ? 123 THR A CB 1 ATOM 950 O OG1 . THR A 1 122 ? -17.649 15.920 -8.681 1.00 75.19 ? 123 THR A OG1 1 ATOM 951 C CG2 . THR A 1 122 ? -18.884 13.988 -8.088 1.00 69.03 ? 123 THR A CG2 1 ATOM 952 N N . ASP A 1 123 ? -16.649 14.130 -4.797 1.00 57.65 ? 124 ASP A N 1 ATOM 953 C CA . ASP A 1 123 ? -16.435 13.048 -3.859 1.00 59.56 ? 124 ASP A CA 1 ATOM 954 C C . ASP A 1 123 ? -16.637 13.435 -2.396 1.00 67.31 ? 124 ASP A C 1 ATOM 955 O O . ASP A 1 123 ? -16.499 12.584 -1.499 1.00 75.52 ? 124 ASP A O 1 ATOM 956 C CB . ASP A 1 123 ? -15.066 12.418 -4.072 1.00 62.66 ? 124 ASP A CB 1 ATOM 957 C CG . ASP A 1 123 ? -15.057 11.392 -5.200 1.00 70.68 ? 124 ASP A CG 1 ATOM 958 O OD1 . ASP A 1 123 ? -16.136 10.940 -5.648 1.00 71.59 ? 124 ASP A OD1 1 ATOM 959 O OD2 . ASP A 1 123 ? -13.947 11.021 -5.642 1.00 72.56 ? 124 ASP A OD2 1 ATOM 960 N N . ASP A 1 124 ? -16.980 14.700 -2.148 1.00 62.70 ? 125 ASP A N 1 ATOM 961 C CA . ASP A 1 124 ? -17.122 15.176 -0.782 1.00 62.80 ? 125 ASP A CA 1 ATOM 962 C C . ASP A 1 124 ? -18.567 15.254 -0.267 1.00 65.29 ? 125 ASP A C 1 ATOM 963 O O . ASP A 1 124 ? -19.488 15.663 -0.978 1.00 63.76 ? 125 ASP A O 1 ATOM 964 C CB . ASP A 1 124 ? -16.432 16.518 -0.613 1.00 64.68 ? 125 ASP A CB 1 ATOM 965 C CG . ASP A 1 124 ? -16.151 16.827 0.836 1.00 74.44 ? 125 ASP A CG 1 ATOM 966 O OD1 . ASP A 1 124 ? -15.325 16.104 1.447 1.00 91.53 ? 125 ASP A OD1 1 ATOM 967 O OD2 . ASP A 1 124 ? -16.763 17.773 1.370 1.00 69.59 ? 125 ASP A OD2 1 ATOM 968 N N . VAL A 1 125 ? -18.749 14.895 0.996 1.00 66.14 ? 126 VAL A N 1 ATOM 969 C CA . VAL A 1 125 ? -20.084 14.810 1.579 1.00 62.23 ? 126 VAL A CA 1 ATOM 970 C C . VAL A 1 125 ? -20.841 16.150 1.622 1.00 60.40 ? 126 VAL A C 1 ATOM 971 O O . VAL A 1 125 ? -22.063 16.157 1.584 1.00 61.41 ? 126 VAL A O 1 ATOM 972 C CB . VAL A 1 125 ? -20.019 14.118 2.959 1.00 63.39 ? 126 VAL A CB 1 ATOM 973 C CG1 . VAL A 1 125 ? -19.489 15.057 4.045 1.00 60.32 ? 126 VAL A CG1 1 ATOM 974 C CG2 . VAL A 1 125 ? -21.366 13.516 3.328 1.00 65.21 ? 126 VAL A CG2 1 ATOM 975 N N . HIS A 1 126 ? -20.108 17.264 1.668 1.00 60.90 ? 127 HIS A N 1 ATOM 976 C CA . HIS A 1 126 ? -20.674 18.618 1.829 1.00 58.37 ? 127 HIS A CA 1 ATOM 977 C C . HIS A 1 126 ? -20.643 19.511 0.589 1.00 57.02 ? 127 HIS A C 1 ATOM 978 O O . HIS A 1 126 ? -21.212 20.592 0.644 1.00 57.59 ? 127 HIS A O 1 ATOM 979 C CB . HIS A 1 126 ? -19.901 19.395 2.897 1.00 61.94 ? 127 HIS A CB 1 ATOM 980 C CG . HIS A 1 126 ? -20.354 19.154 4.298 1.00 69.61 ? 127 HIS A CG 1 ATOM 981 N ND1 . HIS A 1 126 ? -19.729 18.251 5.131 1.00 69.57 ? 127 HIS A ND1 1 ATOM 982 C CD2 . HIS A 1 126 ? -21.333 19.733 5.034 1.00 72.85 ? 127 HIS A CD2 1 ATOM 983 C CE1 . HIS A 1 126 ? -20.326 18.257 6.309 1.00 68.76 ? 127 HIS A CE1 1 ATOM 984 N NE2 . HIS A 1 126 ? -21.299 19.150 6.279 1.00 72.99 ? 127 HIS A NE2 1 ATOM 985 N N . CYS A 1 127 ? -19.955 19.120 -0.495 1.00 57.66 ? 128 CYS A N 1 ATOM 986 C CA . CYS A 1 127 ? -19.650 20.085 -1.574 1.00 58.60 ? 128 CYS A CA 1 ATOM 987 C C . CYS A 1 127 ? -20.810 20.250 -2.526 1.00 56.22 ? 128 CYS A C 1 ATOM 988 O O . CYS A 1 127 ? -21.261 19.262 -3.137 1.00 55.82 ? 128 CYS A O 1 ATOM 989 C CB . CYS A 1 127 ? -18.357 19.750 -2.347 1.00 62.61 ? 128 CYS A CB 1 ATOM 990 S SG . CYS A 1 127 ? -17.799 21.015 -3.546 1.00 81.64 ? 128 CYS A SG 1 ATOM 991 N N . HIS A 1 128 ? -21.273 21.501 -2.625 1.00 49.38 ? 129 HIS A N 1 ATOM 992 C CA . HIS A 1 128 ? -22.175 21.929 -3.685 1.00 49.49 ? 129 HIS A CA 1 ATOM 993 C C . HIS A 1 128 ? -21.441 22.437 -4.908 1.00 48.22 ? 129 HIS A C 1 ATOM 994 O O . HIS A 1 128 ? -21.764 22.036 -6.016 1.00 47.93 ? 129 HIS A O 1 ATOM 995 C CB . HIS A 1 128 ? -23.161 22.989 -3.215 1.00 52.80 ? 129 HIS A CB 1 ATOM 996 C CG . HIS A 1 128 ? -24.052 22.535 -2.106 1.00 57.97 ? 129 HIS A CG 1 ATOM 997 N ND1 . HIS A 1 128 ? -24.913 23.389 -1.454 1.00 63.42 ? 129 HIS A ND1 1 ATOM 998 C CD2 . HIS A 1 128 ? -24.179 21.335 -1.494 1.00 60.24 ? 129 HIS A CD2 1 ATOM 999 C CE1 . HIS A 1 128 ? -25.556 22.727 -0.510 1.00 63.39 ? 129 HIS A CE1 1 ATOM 1000 N NE2 . HIS A 1 128 ? -25.118 21.483 -0.502 1.00 60.52 ? 129 HIS A NE2 1 ATOM 1001 N N . PHE A 1 129 ? -20.476 23.331 -4.699 1.00 52.79 ? 130 PHE A N 1 ATOM 1002 C CA . PHE A 1 129 ? -19.651 23.899 -5.781 1.00 55.75 ? 130 PHE A CA 1 ATOM 1003 C C . PHE A 1 129 ? -18.221 24.318 -5.362 1.00 54.99 ? 130 PHE A C 1 ATOM 1004 O O . PHE A 1 129 ? -17.927 24.450 -4.180 1.00 56.08 ? 130 PHE A O 1 ATOM 1005 C CB . PHE A 1 129 ? -20.398 25.040 -6.491 1.00 55.73 ? 130 PHE A CB 1 ATOM 1006 C CG . PHE A 1 129 ? -20.872 26.127 -5.577 1.00 56.39 ? 130 PHE A CG 1 ATOM 1007 C CD1 . PHE A 1 129 ? -22.117 26.041 -4.965 1.00 57.00 ? 130 PHE A CD1 1 ATOM 1008 C CD2 . PHE A 1 129 ? -20.082 27.257 -5.345 1.00 59.62 ? 130 PHE A CD2 1 ATOM 1009 C CE1 . PHE A 1 129 ? -22.557 27.062 -4.130 1.00 59.86 ? 130 PHE A CE1 1 ATOM 1010 C CE2 . PHE A 1 129 ? -20.513 28.280 -4.499 1.00 59.27 ? 130 PHE A CE2 1 ATOM 1011 C CZ . PHE A 1 129 ? -21.752 28.181 -3.899 1.00 60.02 ? 130 PHE A CZ 1 ATOM 1012 N N . PHE A 1 130 ? -17.351 24.541 -6.345 1.00 58.49 ? 131 PHE A N 1 ATOM 1013 C CA . PHE A 1 130 ? -15.953 24.911 -6.098 1.00 61.96 ? 131 PHE A CA 1 ATOM 1014 C C . PHE A 1 130 ? -15.474 26.111 -6.899 1.00 62.00 ? 131 PHE A C 1 ATOM 1015 O O . PHE A 1 130 ? -16.003 26.394 -7.976 1.00 57.63 ? 131 PHE A O 1 ATOM 1016 C CB . PHE A 1 130 ? -15.032 23.745 -6.452 1.00 69.58 ? 131 PHE A CB 1 ATOM 1017 C CG . PHE A 1 130 ? -15.030 23.399 -7.919 1.00 70.54 ? 131 PHE A CG 1 ATOM 1018 C CD1 . PHE A 1 130 ? -14.277 24.138 -8.831 1.00 68.52 ? 131 PHE A CD1 1 ATOM 1019 C CD2 . PHE A 1 130 ? -15.788 22.327 -8.388 1.00 76.87 ? 131 PHE A CD2 1 ATOM 1020 C CE1 . PHE A 1 130 ? -14.292 23.825 -10.179 1.00 77.72 ? 131 PHE A CE1 1 ATOM 1021 C CE2 . PHE A 1 130 ? -15.813 22.015 -9.739 1.00 78.80 ? 131 PHE A CE2 1 ATOM 1022 C CZ . PHE A 1 130 ? -15.054 22.754 -10.634 1.00 78.86 ? 131 PHE A CZ 1 ATOM 1023 N N . THR A 1 131 ? -14.449 26.783 -6.361 1.00 67.90 ? 132 THR A N 1 ATOM 1024 C CA . THR A 1 131 ? -13.566 27.686 -7.131 1.00 63.56 ? 132 THR A CA 1 ATOM 1025 C C . THR A 1 131 ? -12.104 27.206 -7.033 1.00 65.99 ? 132 THR A C 1 ATOM 1026 O O . THR A 1 131 ? -11.655 26.727 -5.979 1.00 65.57 ? 132 THR A O 1 ATOM 1027 C CB . THR A 1 131 ? -13.693 29.162 -6.719 1.00 51.25 ? 132 THR A CB 1 ATOM 1028 O OG1 . THR A 1 131 ? -15.033 29.426 -6.327 1.00 47.35 ? 132 THR A OG1 1 ATOM 1029 C CG2 . THR A 1 131 ? -13.403 30.027 -7.879 1.00 52.17 ? 132 THR A CG2 1 ATOM 1030 N N . TYR A 1 132 ? -11.405 27.316 -8.162 1.00 67.47 ? 133 TYR A N 1 ATOM 1031 C CA . TYR A 1 132 ? -10.028 26.888 -8.326 1.00 68.55 ? 133 TYR A CA 1 ATOM 1032 C C . TYR A 1 132 ? -9.213 28.031 -8.918 1.00 75.59 ? 133 TYR A C 1 ATOM 1033 O O . TYR A 1 132 ? -9.591 28.606 -9.963 1.00 78.90 ? 133 TYR A O 1 ATOM 1034 C CB . TYR A 1 132 ? -9.983 25.698 -9.278 1.00 70.30 ? 133 TYR A CB 1 ATOM 1035 C CG . TYR A 1 132 ? -8.594 25.154 -9.570 1.00 69.82 ? 133 TYR A CG 1 ATOM 1036 C CD1 . TYR A 1 132 ? -7.898 24.417 -8.609 1.00 69.47 ? 133 TYR A CD1 1 ATOM 1037 C CD2 . TYR A 1 132 ? -7.989 25.349 -10.811 1.00 65.27 ? 133 TYR A CD2 1 ATOM 1038 C CE1 . TYR A 1 132 ? -6.643 23.906 -8.872 1.00 66.42 ? 133 TYR A CE1 1 ATOM 1039 C CE2 . TYR A 1 132 ? -6.733 24.840 -11.073 1.00 64.71 ? 133 TYR A CE2 1 ATOM 1040 C CZ . TYR A 1 132 ? -6.073 24.121 -10.098 1.00 65.41 ? 133 TYR A CZ 1 ATOM 1041 O OH . TYR A 1 132 ? -4.831 23.606 -10.335 1.00 75.88 ? 133 TYR A OH 1 ATOM 1042 N N . ALA A 1 133 ? -8.104 28.354 -8.249 1.00 73.75 ? 134 ALA A N 1 ATOM 1043 C CA . ALA A 1 133 ? -7.162 29.360 -8.739 1.00 73.10 ? 134 ALA A CA 1 ATOM 1044 C C . ALA A 1 133 ? -6.092 28.696 -9.595 1.00 72.05 ? 134 ALA A C 1 ATOM 1045 O O . ALA A 1 133 ? -5.308 27.852 -9.146 1.00 63.01 ? 134 ALA A O 1 ATOM 1046 C CB . ALA A 1 133 ? -6.558 30.173 -7.600 1.00 72.32 ? 134 ALA A CB 1 ATOM 1047 N N . THR A 1 134 ? -6.105 29.077 -10.860 1.00 79.14 ? 135 THR A N 1 ATOM 1048 C CA . THR A 1 134 ? -5.192 28.535 -11.850 1.00 88.30 ? 135 THR A CA 1 ATOM 1049 C C . THR A 1 134 ? -3.750 28.941 -11.540 1.00 93.73 ? 135 THR A C 1 ATOM 1050 O O . THR A 1 134 ? -3.512 29.933 -10.853 1.00 100.13 ? 135 THR A O 1 ATOM 1051 C CB . THR A 1 134 ? -5.562 29.064 -13.243 1.00 87.78 ? 135 THR A CB 1 ATOM 1052 O OG1 . THR A 1 134 ? -5.843 30.467 -13.145 1.00 82.14 ? 135 THR A OG1 1 ATOM 1053 C CG2 . THR A 1 134 ? -6.790 28.327 -13.803 1.00 85.23 ? 135 THR A CG2 1 ATOM 1054 N N . ARG A 1 135 ? -2.803 28.151 -12.040 1.00 102.14 ? 136 ARG A N 1 ATOM 1055 C CA . ARG A 1 135 ? -1.392 28.530 -12.145 1.00 97.17 ? 136 ARG A CA 1 ATOM 1056 C C . ARG A 1 135 ? -1.221 30.041 -12.378 1.00 90.59 ? 136 ARG A C 1 ATOM 1057 O O . ARG A 1 135 ? -0.463 30.690 -11.675 1.00 103.79 ? 136 ARG A O 1 ATOM 1058 C CB . ARG A 1 135 ? -0.746 27.715 -13.281 1.00 103.25 ? 136 ARG A CB 1 ATOM 1059 C CG . ARG A 1 135 ? 0.555 28.259 -13.840 1.00 117.62 ? 136 ARG A CG 1 ATOM 1060 C CD . ARG A 1 135 ? 1.728 27.853 -12.960 1.00 133.61 ? 136 ARG A CD 1 ATOM 1061 N NE . ARG A 1 135 ? 2.936 28.633 -13.228 1.00 122.75 ? 136 ARG A NE 1 ATOM 1062 C CZ . ARG A 1 135 ? 4.172 28.232 -12.943 1.00 114.81 ? 136 ARG A CZ 1 ATOM 1063 N NH1 . ARG A 1 135 ? 4.387 27.042 -12.388 1.00 112.47 ? 136 ARG A NH1 1 ATOM 1064 N NH2 . ARG A 1 135 ? 5.197 29.024 -13.234 1.00 114.91 ? 136 ARG A NH2 1 ATOM 1065 N N . GLN A 1 136 ? -1.973 30.593 -13.323 1.00 80.46 ? 137 GLN A N 1 ATOM 1066 C CA . GLN A 1 136 ? -1.847 31.986 -13.740 1.00 75.22 ? 137 GLN A CA 1 ATOM 1067 C C . GLN A 1 136 ? -2.383 33.059 -12.790 1.00 71.48 ? 137 GLN A C 1 ATOM 1068 O O . GLN A 1 136 ? -2.340 34.254 -13.123 1.00 69.32 ? 137 GLN A O 1 ATOM 1069 C CB . GLN A 1 136 ? -2.519 32.160 -15.080 1.00 78.34 ? 137 GLN A CB 1 ATOM 1070 C CG . GLN A 1 136 ? -1.784 31.519 -16.226 1.00 88.35 ? 137 GLN A CG 1 ATOM 1071 C CD . GLN A 1 136 ? -2.471 31.822 -17.533 1.00 105.66 ? 137 GLN A CD 1 ATOM 1072 O OE1 . GLN A 1 136 ? -3.701 31.807 -17.616 1.00 117.78 ? 137 GLN A OE1 1 ATOM 1073 N NE2 . GLN A 1 136 ? -1.685 32.118 -18.563 1.00 113.96 ? 137 GLN A NE2 1 ATOM 1074 N N . PHE A 1 137 ? -2.877 32.644 -11.627 1.00 70.74 ? 138 PHE A N 1 ATOM 1075 C CA . PHE A 1 137 ? -3.458 33.572 -10.636 1.00 76.52 ? 138 PHE A CA 1 ATOM 1076 C C . PHE A 1 137 ? -2.343 34.381 -9.923 1.00 78.02 ? 138 PHE A C 1 ATOM 1077 O O . PHE A 1 137 ? -1.365 33.767 -9.433 1.00 74.46 ? 138 PHE A O 1 ATOM 1078 C CB . PHE A 1 137 ? -4.371 32.804 -9.628 1.00 71.73 ? 138 PHE A CB 1 ATOM 1079 C CG . PHE A 1 137 ? -5.179 33.695 -8.687 1.00 68.65 ? 138 PHE A CG 1 ATOM 1080 C CD1 . PHE A 1 137 ? -6.306 34.397 -9.142 1.00 64.59 ? 138 PHE A CD1 1 ATOM 1081 C CD2 . PHE A 1 137 ? -4.838 33.800 -7.326 1.00 66.40 ? 138 PHE A CD2 1 ATOM 1082 C CE1 . PHE A 1 137 ? -7.049 35.199 -8.279 1.00 60.07 ? 138 PHE A CE1 1 ATOM 1083 C CE2 . PHE A 1 137 ? -5.576 34.614 -6.466 1.00 58.70 ? 138 PHE A CE2 1 ATOM 1084 C CZ . PHE A 1 137 ? -6.687 35.308 -6.942 1.00 58.53 ? 138 PHE A CZ 1 ATOM 1085 N N . PRO A 1 138 ? -2.488 35.742 -9.872 1.00 72.22 ? 139 PRO A N 1 ATOM 1086 C CA . PRO A 1 138 ? -1.600 36.678 -9.173 1.00 71.45 ? 139 PRO A CA 1 ATOM 1087 C C . PRO A 1 138 ? -1.014 36.163 -7.838 1.00 69.64 ? 139 PRO A C 1 ATOM 1088 O O . PRO A 1 138 ? 0.081 35.600 -7.844 1.00 70.91 ? 139 PRO A O 1 ATOM 1089 C CB . PRO A 1 138 ? -2.497 37.905 -8.956 1.00 74.88 ? 139 PRO A CB 1 ATOM 1090 C CG . PRO A 1 138 ? -3.406 37.902 -10.125 1.00 74.98 ? 139 PRO A CG 1 ATOM 1091 C CD . PRO A 1 138 ? -3.555 36.473 -10.588 1.00 73.76 ? 139 PRO A CD 1 ATOM 1092 N N . SER A 1 139 ? -1.714 36.351 -6.718 1.00 71.57 ? 140 SER A N 1 ATOM 1093 C CA . SER A 1 139 ? -1.194 35.945 -5.400 1.00 80.92 ? 140 SER A CA 1 ATOM 1094 C C . SER A 1 139 ? -0.589 34.564 -5.481 1.00 82.75 ? 140 SER A C 1 ATOM 1095 O O . SER A 1 139 ? -1.274 33.591 -5.778 1.00 86.51 ? 140 SER A O 1 ATOM 1096 C CB . SER A 1 139 ? -2.274 35.955 -4.324 1.00 77.80 ? 140 SER A CB 1 ATOM 1097 O OG . SER A 1 139 ? -3.017 37.152 -4.397 1.00 84.80 ? 140 SER A OG 1 ATOM 1098 N N . LEU A 1 140 ? 0.716 34.498 -5.260 1.00 89.82 ? 141 LEU A N 1 ATOM 1099 C CA . LEU A 1 140 ? 1.412 33.222 -5.283 1.00 82.99 ? 141 LEU A CA 1 ATOM 1100 C C . LEU A 1 140 ? 0.940 32.354 -4.145 1.00 78.24 ? 141 LEU A C 1 ATOM 1101 O O . LEU A 1 140 ? 0.925 31.151 -4.287 1.00 75.47 ? 141 LEU A O 1 ATOM 1102 C CB . LEU A 1 140 ? 2.930 33.408 -5.273 1.00 85.25 ? 141 LEU A CB 1 ATOM 1103 C CG . LEU A 1 140 ? 3.508 33.716 -6.664 1.00 88.80 ? 141 LEU A CG 1 ATOM 1104 C CD1 . LEU A 1 140 ? 3.234 35.151 -7.122 1.00 97.18 ? 141 LEU A CD1 1 ATOM 1105 C CD2 . LEU A 1 140 ? 5.000 33.422 -6.700 1.00 89.08 ? 141 LEU A CD2 1 ATOM 1106 N N . GLU A 1 141 ? 0.495 32.980 -3.053 1.00 87.96 ? 142 GLU A N 1 ATOM 1107 C CA . GLU A 1 141 ? -0.086 32.273 -1.916 1.00 96.98 ? 142 GLU A CA 1 ATOM 1108 C C . GLU A 1 141 ? -1.340 31.473 -2.298 1.00 99.15 ? 142 GLU A C 1 ATOM 1109 O O . GLU A 1 141 ? -1.593 30.412 -1.712 1.00 94.02 ? 142 GLU A O 1 ATOM 1110 C CB . GLU A 1 141 ? -0.378 33.251 -0.758 1.00 107.73 ? 142 GLU A CB 1 ATOM 1111 C CG . GLU A 1 141 ? -0.586 32.601 0.624 1.00 121.48 ? 142 GLU A CG 1 ATOM 1112 C CD . GLU A 1 141 ? 0.674 31.961 1.253 1.00 129.36 ? 142 GLU A CD 1 ATOM 1113 O OE1 . GLU A 1 141 ? 0.957 32.229 2.446 1.00 118.10 ? 142 GLU A OE1 1 ATOM 1114 O OE2 . GLU A 1 141 ? 1.387 31.166 0.591 1.00 132.58 ? 142 GLU A OE2 1 ATOM 1115 N N . HIS A 1 142 ? -2.066 31.963 -3.315 1.00 103.37 ? 143 HIS A N 1 ATOM 1116 C CA . HIS A 1 142 ? -3.428 31.496 -3.682 1.00 99.13 ? 143 HIS A CA 1 ATOM 1117 C C . HIS A 1 142 ? -3.576 30.619 -4.943 1.00 94.17 ? 143 HIS A C 1 ATOM 1118 O O . HIS A 1 142 ? -4.369 29.654 -4.970 1.00 86.11 ? 143 HIS A O 1 ATOM 1119 C CB . HIS A 1 142 ? -4.365 32.696 -3.791 1.00 93.46 ? 143 HIS A CB 1 ATOM 1120 C CG . HIS A 1 142 ? -4.598 33.395 -2.494 1.00 91.84 ? 143 HIS A CG 1 ATOM 1121 N ND1 . HIS A 1 142 ? -4.674 32.726 -1.291 1.00 95.38 ? 143 HIS A ND1 1 ATOM 1122 C CD2 . HIS A 1 142 ? -4.797 34.703 -2.213 1.00 90.52 ? 143 HIS A CD2 1 ATOM 1123 C CE1 . HIS A 1 142 ? -4.894 33.596 -0.321 1.00 104.03 ? 143 HIS A CE1 1 ATOM 1124 N NE2 . HIS A 1 142 ? -4.981 34.801 -0.856 1.00 97.10 ? 143 HIS A NE2 1 ATOM 1125 N N . ARG A 1 143 ? -2.847 30.996 -5.988 1.00 90.17 ? 144 ARG A N 1 ATOM 1126 C CA . ARG A 1 143 ? -2.627 30.167 -7.169 1.00 90.83 ? 144 ARG A CA 1 ATOM 1127 C C . ARG A 1 143 ? -2.562 28.672 -6.802 1.00 84.37 ? 144 ARG A C 1 ATOM 1128 O O . ARG A 1 143 ? -1.824 28.294 -5.901 1.00 72.93 ? 144 ARG A O 1 ATOM 1129 C CB . ARG A 1 143 ? -1.354 30.673 -7.867 1.00 91.60 ? 144 ARG A CB 1 ATOM 1130 C CG . ARG A 1 143 ? -0.429 29.649 -8.504 1.00 92.80 ? 144 ARG A CG 1 ATOM 1131 C CD . ARG A 1 143 ? 0.969 30.230 -8.718 1.00 100.02 ? 144 ARG A CD 1 ATOM 1132 N NE . ARG A 1 143 ? 0.953 31.616 -9.217 1.00 100.94 ? 144 ARG A NE 1 ATOM 1133 C CZ . ARG A 1 143 ? 1.926 32.196 -9.924 1.00 97.29 ? 144 ARG A CZ 1 ATOM 1134 N NH1 . ARG A 1 143 ? 3.025 31.534 -10.265 1.00 100.05 ? 144 ARG A NH1 1 ATOM 1135 N NH2 . ARG A 1 143 ? 1.792 33.453 -10.309 1.00 95.46 ? 144 ARG A NH2 1 ATOM 1136 N N . ASN A 1 144 ? -3.387 27.861 -7.473 1.00 88.50 ? 145 ASN A N 1 ATOM 1137 C CA . ASN A 1 144 ? -3.513 26.394 -7.252 1.00 87.19 ? 145 ASN A CA 1 ATOM 1138 C C . ASN A 1 144 ? -4.371 25.902 -6.091 1.00 85.13 ? 145 ASN A C 1 ATOM 1139 O O . ASN A 1 144 ? -4.592 24.683 -5.966 1.00 74.09 ? 145 ASN A O 1 ATOM 1140 C CB . ASN A 1 144 ? -2.152 25.692 -7.226 1.00 86.49 ? 145 ASN A CB 1 ATOM 1141 C CG . ASN A 1 144 ? -1.720 25.238 -8.590 1.00 88.85 ? 145 ASN A CG 1 ATOM 1142 O OD1 . ASN A 1 144 ? -2.011 25.887 -9.600 1.00 100.59 ? 145 ASN A OD1 1 ATOM 1143 N ND2 . ASN A 1 144 ? -1.019 24.118 -8.635 1.00 88.09 ? 145 ASN A ND2 1 ATOM 1144 N N . ILE A 1 145 ? -4.848 26.826 -5.250 1.00 82.38 ? 146 ILE A N 1 ATOM 1145 C CA . ILE A 1 145 ? -5.735 26.434 -4.155 1.00 78.81 ? 146 ILE A CA 1 ATOM 1146 C C . ILE A 1 145 ? -7.134 26.142 -4.695 1.00 76.01 ? 146 ILE A C 1 ATOM 1147 O O . ILE A 1 145 ? -7.639 26.882 -5.537 1.00 69.29 ? 146 ILE A O 1 ATOM 1148 C CB . ILE A 1 145 ? -5.683 27.400 -2.937 1.00 75.22 ? 146 ILE A CB 1 ATOM 1149 C CG1 . ILE A 1 145 ? -4.495 26.992 -2.042 1.00 72.77 ? 146 ILE A CG1 1 ATOM 1150 C CG2 . ILE A 1 145 ? -6.998 27.387 -2.143 1.00 72.34 ? 146 ILE A CG2 1 ATOM 1151 C CD1 . ILE A 1 145 ? -4.259 27.805 -0.775 1.00 76.50 ? 146 ILE A CD1 1 ATOM 1152 N N . CYS A 1 146 ? -7.691 25.015 -4.224 1.00 80.82 ? 147 CYS A N 1 ATOM 1153 C CA . CYS A 1 146 ? -9.041 24.507 -4.538 1.00 75.50 ? 147 CYS A CA 1 ATOM 1154 C C . CYS A 1 146 ? -9.952 24.558 -3.310 1.00 68.94 ? 147 CYS A C 1 ATOM 1155 O O . CYS A 1 146 ? -9.952 23.637 -2.468 1.00 66.59 ? 147 CYS A O 1 ATOM 1156 C CB . CYS A 1 146 ? -8.969 23.065 -5.070 1.00 76.28 ? 147 CYS A CB 1 ATOM 1157 S SG . CYS A 1 146 ? -10.561 22.198 -5.204 1.00 76.63 ? 147 CYS A SG 1 ATOM 1158 N N . LEU A 1 147 ? -10.739 25.627 -3.221 1.00 65.52 ? 148 LEU A N 1 ATOM 1159 C CA . LEU A 1 147 ? -11.605 25.781 -2.072 1.00 69.72 ? 148 LEU A CA 1 ATOM 1160 C C . LEU A 1 147 ? -13.053 25.454 -2.397 1.00 72.42 ? 148 LEU A C 1 ATOM 1161 O O . LEU A 1 147 ? -13.634 25.972 -3.363 1.00 75.55 ? 148 LEU A O 1 ATOM 1162 C CB . LEU A 1 147 ? -11.413 27.136 -1.360 1.00 69.95 ? 148 LEU A CB 1 ATOM 1163 C CG . LEU A 1 147 ? -12.288 28.374 -1.522 1.00 69.15 ? 148 LEU A CG 1 ATOM 1164 C CD1 . LEU A 1 147 ? -11.891 29.431 -0.514 1.00 71.28 ? 148 LEU A CD1 1 ATOM 1165 C CD2 . LEU A 1 147 ? -12.173 28.923 -2.921 1.00 76.59 ? 148 LEU A CD2 1 ATOM 1166 N N . LEU A 1 148 ? -13.590 24.556 -1.571 1.00 66.42 ? 149 LEU A N 1 ATOM 1167 C CA . LEU A 1 148 ? -14.919 23.998 -1.709 1.00 61.12 ? 149 LEU A CA 1 ATOM 1168 C C . LEU A 1 148 ? -15.909 24.849 -0.941 1.00 62.32 ? 149 LEU A C 1 ATOM 1169 O O . LEU A 1 148 ? -15.538 25.533 0.007 1.00 72.13 ? 149 LEU A O 1 ATOM 1170 C CB . LEU A 1 148 ? -14.930 22.563 -1.184 1.00 56.75 ? 149 LEU A CB 1 ATOM 1171 C CG . LEU A 1 148 ? -13.759 21.655 -1.597 1.00 55.61 ? 149 LEU A CG 1 ATOM 1172 C CD1 . LEU A 1 148 ? -13.814 20.334 -0.855 1.00 47.25 ? 149 LEU A CD1 1 ATOM 1173 C CD2 . LEU A 1 148 ? -13.716 21.426 -3.105 1.00 59.61 ? 149 LEU A CD2 1 ATOM 1174 N N . LYS A 1 149 ? -17.168 24.805 -1.362 1.00 59.76 ? 150 LYS A N 1 ATOM 1175 C CA . LYS A 1 149 ? -18.201 25.662 -0.830 1.00 56.74 ? 150 LYS A CA 1 ATOM 1176 C C . LYS A 1 149 ? -19.570 24.959 -0.769 1.00 62.13 ? 150 LYS A C 1 ATOM 1177 O O . LYS A 1 149 ? -19.835 23.997 -1.508 1.00 63.83 ? 150 LYS A O 1 ATOM 1178 C CB . LYS A 1 149 ? -18.297 26.900 -1.696 1.00 58.50 ? 150 LYS A CB 1 ATOM 1179 C CG . LYS A 1 149 ? -16.975 27.371 -2.269 1.00 62.69 ? 150 LYS A CG 1 ATOM 1180 C CD . LYS A 1 149 ? -17.145 28.757 -2.845 1.00 73.33 ? 150 LYS A CD 1 ATOM 1181 C CE . LYS A 1 149 ? -15.850 29.274 -3.425 1.00 69.28 ? 150 LYS A CE 1 ATOM 1182 N NZ . LYS A 1 149 ? -15.947 30.745 -3.617 1.00 78.18 ? 150 LYS A NZ 1 ATOM 1183 N N . HIS A 1 150 ? -20.424 25.431 0.135 1.00 62.51 ? 151 HIS A N 1 ATOM 1184 C CA . HIS A 1 150 ? -21.830 25.034 0.190 1.00 63.84 ? 151 HIS A CA 1 ATOM 1185 C C . HIS A 1 150 ? -22.701 26.235 0.577 1.00 61.75 ? 151 HIS A C 1 ATOM 1186 O O . HIS A 1 150 ? -22.202 27.206 1.154 1.00 56.11 ? 151 HIS A O 1 ATOM 1187 C CB . HIS A 1 150 ? -22.060 23.822 1.126 1.00 71.96 ? 151 HIS A CB 1 ATOM 1188 C CG . HIS A 1 150 ? -21.742 24.072 2.577 1.00 89.93 ? 151 HIS A CG 1 ATOM 1189 N ND1 . HIS A 1 150 ? -22.649 24.639 3.456 1.00 103.62 ? 151 HIS A ND1 1 ATOM 1190 C CD2 . HIS A 1 150 ? -20.636 23.788 3.313 1.00 99.61 ? 151 HIS A CD2 1 ATOM 1191 C CE1 . HIS A 1 150 ? -22.106 24.720 4.661 1.00 100.93 ? 151 HIS A CE1 1 ATOM 1192 N NE2 . HIS A 1 150 ? -20.883 24.211 4.602 1.00 99.54 ? 151 HIS A NE2 1 ATOM 1193 N N . THR A 1 151 ? -23.983 26.174 0.213 1.00 59.82 ? 152 THR A N 1 ATOM 1194 C CA . THR A 1 151 ? -24.998 27.128 0.654 1.00 62.05 ? 152 THR A CA 1 ATOM 1195 C C . THR A 1 151 ? -26.261 26.377 1.081 1.00 69.42 ? 152 THR A C 1 ATOM 1196 O O . THR A 1 151 ? -26.330 25.176 0.900 1.00 74.27 ? 152 THR A O 1 ATOM 1197 C CB . THR A 1 151 ? -25.390 28.120 -0.461 1.00 63.50 ? 152 THR A CB 1 ATOM 1198 O OG1 . THR A 1 151 ? -26.107 27.445 -1.515 1.00 61.85 ? 152 THR A OG1 1 ATOM 1199 C CG2 . THR A 1 151 ? -24.173 28.880 -0.994 1.00 59.24 ? 152 THR A CG2 1 ATOM 1200 N N . GLN A 1 152 ? -27.261 27.084 1.619 1.00 74.91 ? 153 GLN A N 1 ATOM 1201 C CA . GLN A 1 152 ? -28.561 26.479 1.947 1.00 73.78 ? 153 GLN A CA 1 ATOM 1202 C C . GLN A 1 152 ? -29.241 25.877 0.717 1.00 74.84 ? 153 GLN A C 1 ATOM 1203 O O . GLN A 1 152 ? -29.728 24.756 0.792 1.00 88.12 ? 153 GLN A O 1 ATOM 1204 C CB . GLN A 1 152 ? -29.527 27.466 2.616 1.00 83.38 ? 153 GLN A CB 1 ATOM 1205 C CG . GLN A 1 152 ? -28.917 28.728 3.208 1.00 97.44 ? 153 GLN A CG 1 ATOM 1206 C CD . GLN A 1 152 ? -29.747 29.298 4.346 1.00 97.84 ? 153 GLN A CD 1 ATOM 1207 O OE1 . GLN A 1 152 ? -30.482 30.282 4.181 1.00 89.05 ? 153 GLN A OE1 1 ATOM 1208 N NE2 . GLN A 1 152 ? -29.632 28.678 5.515 1.00 98.12 ? 153 GLN A NE2 1 ATOM 1209 N N . THR A 1 153 ? -29.259 26.605 -0.403 1.00 73.54 ? 154 THR A N 1 ATOM 1210 C CA . THR A 1 153 ? -29.971 26.167 -1.631 1.00 71.81 ? 154 THR A CA 1 ATOM 1211 C C . THR A 1 153 ? -29.201 25.217 -2.550 1.00 70.70 ? 154 THR A C 1 ATOM 1212 O O . THR A 1 153 ? -29.811 24.590 -3.427 1.00 66.95 ? 154 THR A O 1 ATOM 1213 C CB . THR A 1 153 ? -30.334 27.348 -2.555 1.00 71.44 ? 154 THR A CB 1 ATOM 1214 O OG1 . THR A 1 153 ? -29.135 28.066 -2.896 1.00 72.94 ? 154 THR A OG1 1 ATOM 1215 C CG2 . THR A 1 153 ? -31.352 28.259 -1.912 1.00 68.40 ? 154 THR A CG2 1 ATOM 1216 N N . GLY A 1 154 ? -27.876 25.161 -2.396 1.00 65.57 ? 155 GLY A N 1 ATOM 1217 C CA . GLY A 1 154 ? -27.015 24.530 -3.398 1.00 59.72 ? 155 GLY A CA 1 ATOM 1218 C C . GLY A 1 154 ? -26.487 25.475 -4.469 1.00 58.92 ? 155 GLY A C 1 ATOM 1219 O O . GLY A 1 154 ? -25.497 25.152 -5.132 1.00 55.08 ? 155 GLY A O 1 ATOM 1220 N N . THR A 1 155 ? -27.156 26.623 -4.647 1.00 58.93 ? 156 THR A N 1 ATOM 1221 C CA . THR A 1 155 ? -26.719 27.681 -5.569 1.00 59.08 ? 156 THR A CA 1 ATOM 1222 C C . THR A 1 155 ? -25.926 28.751 -4.794 1.00 61.58 ? 156 THR A C 1 ATOM 1223 O O . THR A 1 155 ? -26.106 28.856 -3.584 1.00 58.07 ? 156 THR A O 1 ATOM 1224 C CB . THR A 1 155 ? -27.892 28.301 -6.357 1.00 61.51 ? 156 THR A CB 1 ATOM 1225 O OG1 . THR A 1 155 ? -28.785 29.002 -5.485 1.00 60.93 ? 156 THR A OG1 1 ATOM 1226 C CG2 . THR A 1 155 ? -28.651 27.228 -7.082 1.00 66.26 ? 156 THR A CG2 1 ATOM 1227 N N . PRO A 1 156 ? -25.021 29.515 -5.478 1.00 66.98 ? 157 PRO A N 1 ATOM 1228 C CA . PRO A 1 156 ? -24.181 30.517 -4.791 1.00 64.01 ? 157 PRO A CA 1 ATOM 1229 C C . PRO A 1 156 ? -24.936 31.701 -4.239 1.00 59.62 ? 157 PRO A C 1 ATOM 1230 O O . PRO A 1 156 ? -25.931 32.142 -4.837 1.00 59.98 ? 157 PRO A O 1 ATOM 1231 C CB . PRO A 1 156 ? -23.231 31.007 -5.890 1.00 65.34 ? 157 PRO A CB 1 ATOM 1232 C CG . PRO A 1 156 ? -23.912 30.678 -7.162 1.00 63.60 ? 157 PRO A CG 1 ATOM 1233 C CD . PRO A 1 156 ? -24.621 29.392 -6.897 1.00 67.28 ? 157 PRO A CD 1 ATOM 1234 N N . THR A 1 157 ? -24.450 32.200 -3.107 1.00 55.75 ? 158 THR A N 1 ATOM 1235 C CA . THR A 1 157 ? -25.022 33.378 -2.472 1.00 59.13 ? 158 THR A CA 1 ATOM 1236 C C . THR A 1 157 ? -24.703 34.608 -3.277 1.00 64.45 ? 158 THR A C 1 ATOM 1237 O O . THR A 1 157 ? -25.412 35.593 -3.166 1.00 71.83 ? 158 THR A O 1 ATOM 1238 C CB . THR A 1 157 ? -24.497 33.600 -1.060 1.00 58.91 ? 158 THR A CB 1 ATOM 1239 O OG1 . THR A 1 157 ? -23.068 33.562 -1.085 1.00 64.66 ? 158 THR A OG1 1 ATOM 1240 C CG2 . THR A 1 157 ? -25.015 32.536 -0.127 1.00 64.22 ? 158 THR A CG2 1 ATOM 1241 N N . ARG A 1 158 ? -23.619 34.555 -4.056 1.00 73.41 ? 159 ARG A N 1 ATOM 1242 C CA . ARG A 1 158 ? -23.328 35.549 -5.105 1.00 82.36 ? 159 ARG A CA 1 ATOM 1243 C C . ARG A 1 158 ? -22.392 35.019 -6.210 1.00 79.37 ? 159 ARG A C 1 ATOM 1244 O O . ARG A 1 158 ? -21.681 34.011 -6.022 1.00 76.61 ? 159 ARG A O 1 ATOM 1245 C CB . ARG A 1 158 ? -22.796 36.866 -4.516 1.00 89.20 ? 159 ARG A CB 1 ATOM 1246 C CG . ARG A 1 158 ? -23.249 38.048 -5.342 1.00 103.14 ? 159 ARG A CG 1 ATOM 1247 C CD . ARG A 1 158 ? -22.900 39.379 -4.730 1.00 115.75 ? 159 ARG A CD 1 ATOM 1248 N NE . ARG A 1 158 ? -22.752 40.342 -5.818 1.00 138.78 ? 159 ARG A NE 1 ATOM 1249 C CZ . ARG A 1 158 ? -21.634 41.006 -6.108 1.00 141.21 ? 159 ARG A CZ 1 ATOM 1250 N NH1 . ARG A 1 158 ? -21.619 41.845 -7.140 1.00 133.41 ? 159 ARG A NH1 1 ATOM 1251 N NH2 . ARG A 1 158 ? -20.538 40.856 -5.362 1.00 134.99 ? 159 ARG A NH2 1 ATOM 1252 N N . ILE A 1 159 ? -22.415 35.693 -7.361 1.00 68.98 ? 160 ILE A N 1 ATOM 1253 C CA . ILE A 1 159 ? -21.458 35.409 -8.428 1.00 72.04 ? 160 ILE A CA 1 ATOM 1254 C C . ILE A 1 159 ? -20.746 36.687 -8.916 1.00 75.33 ? 160 ILE A C 1 ATOM 1255 O O . ILE A 1 159 ? -21.384 37.663 -9.321 1.00 81.25 ? 160 ILE A O 1 ATOM 1256 C CB . ILE A 1 159 ? -22.111 34.624 -9.586 1.00 66.90 ? 160 ILE A CB 1 ATOM 1257 C CG1 . ILE A 1 159 ? -22.373 33.178 -9.176 1.00 64.95 ? 160 ILE A CG1 1 ATOM 1258 C CG2 . ILE A 1 159 ? -21.207 34.594 -10.799 1.00 68.30 ? 160 ILE A CG2 1 ATOM 1259 C CD1 . ILE A 1 159 ? -23.381 32.489 -10.069 1.00 66.76 ? 160 ILE A CD1 1 ATOM 1260 N N . THR A 1 160 ? -19.416 36.670 -8.861 1.00 77.98 ? 161 THR A N 1 ATOM 1261 C CA . THR A 1 160 ? -18.587 37.808 -9.317 1.00 78.86 ? 161 THR A CA 1 ATOM 1262 C C . THR A 1 160 ? -17.545 37.392 -10.365 1.00 77.29 ? 161 THR A C 1 ATOM 1263 O O . THR A 1 160 ? -17.069 36.247 -10.361 1.00 83.53 ? 161 THR A O 1 ATOM 1264 C CB . THR A 1 160 ? -17.886 38.512 -8.138 1.00 73.64 ? 161 THR A CB 1 ATOM 1265 O OG1 . THR A 1 160 ? -17.008 37.596 -7.477 1.00 74.26 ? 161 THR A OG1 1 ATOM 1266 C CG2 . THR A 1 160 ? -18.909 39.011 -7.138 1.00 74.49 ? 161 THR A CG2 1 ATOM 1267 N N . LYS A 1 161 ? -17.210 38.299 -11.281 1.00 75.46 ? 162 LYS A N 1 ATOM 1268 C CA . LYS A 1 161 ? -16.128 38.007 -12.217 1.00 81.28 ? 162 LYS A CA 1 ATOM 1269 C C . LYS A 1 161 ? -14.740 38.268 -11.582 1.00 80.31 ? 162 LYS A C 1 ATOM 1270 O O . LYS A 1 161 ? -14.548 39.279 -10.905 1.00 82.70 ? 162 LYS A O 1 ATOM 1271 C CB . LYS A 1 161 ? -16.343 38.687 -13.572 1.00 80.70 ? 162 LYS A CB 1 ATOM 1272 C CG . LYS A 1 161 ? -16.980 37.757 -14.607 1.00 82.00 ? 162 LYS A CG 1 ATOM 1273 C CD . LYS A 1 161 ? -16.590 38.066 -16.051 1.00 86.79 ? 162 LYS A CD 1 ATOM 1274 C CE . LYS A 1 161 ? -15.088 38.189 -16.299 1.00 96.36 ? 162 LYS A CE 1 ATOM 1275 N NZ . LYS A 1 161 ? -14.738 39.508 -16.909 1.00 81.80 ? 162 LYS A NZ 1 ATOM 1276 N N . LEU A 1 162 ? -13.825 37.307 -11.740 1.00 74.50 ? 163 LEU A N 1 ATOM 1277 C CA . LEU A 1 162 ? -12.465 37.361 -11.185 1.00 78.35 ? 163 LEU A CA 1 ATOM 1278 C C . LEU A 1 162 ? -11.487 36.574 -12.066 1.00 86.38 ? 163 LEU A C 1 ATOM 1279 O O . LEU A 1 162 ? -11.518 35.338 -12.104 1.00 89.62 ? 163 LEU A O 1 ATOM 1280 C CB . LEU A 1 162 ? -12.411 36.890 -9.719 1.00 75.48 ? 163 LEU A CB 1 ATOM 1281 C CG . LEU A 1 162 ? -11.016 36.713 -9.060 1.00 83.23 ? 163 LEU A CG 1 ATOM 1282 C CD1 . LEU A 1 162 ? -10.445 38.006 -8.473 1.00 86.55 ? 163 LEU A CD1 1 ATOM 1283 C CD2 . LEU A 1 162 ? -11.006 35.621 -7.991 1.00 81.50 ? 163 LEU A CD2 1 ATOM 1284 N N . ASP A 1 163 ? -10.619 37.317 -12.757 1.00 95.14 ? 164 ASP A N 1 ATOM 1285 C CA . ASP A 1 163 ? -9.697 36.773 -13.755 1.00 95.50 ? 164 ASP A CA 1 ATOM 1286 C C . ASP A 1 163 ? -8.765 35.709 -13.207 1.00 88.30 ? 164 ASP A C 1 ATOM 1287 O O . ASP A 1 163 ? -8.347 35.772 -12.054 1.00 82.58 ? 164 ASP A O 1 ATOM 1288 C CB . ASP A 1 163 ? -8.894 37.899 -14.419 1.00 112.37 ? 164 ASP A CB 1 ATOM 1289 C CG . ASP A 1 163 ? -9.538 38.403 -15.714 1.00 125.72 ? 164 ASP A CG 1 ATOM 1290 O OD1 . ASP A 1 163 ? -10.752 38.753 -15.707 1.00 124.74 ? 164 ASP A OD1 1 ATOM 1291 O OD2 . ASP A 1 163 ? -8.817 38.445 -16.742 1.00 120.23 ? 164 ASP A OD2 1 ATOM 1292 N N . LYS A 1 164 ? -8.466 34.733 -14.060 1.00 87.44 ? 165 LYS A N 1 ATOM 1293 C CA . LYS A 1 164 ? -7.619 33.571 -13.735 1.00 95.26 ? 165 LYS A CA 1 ATOM 1294 C C . LYS A 1 164 ? -8.183 32.637 -12.626 1.00 94.52 ? 165 LYS A C 1 ATOM 1295 O O . LYS A 1 164 ? -7.430 31.983 -11.878 1.00 94.53 ? 165 LYS A O 1 ATOM 1296 C CB . LYS A 1 164 ? -6.144 33.976 -13.470 1.00 98.66 ? 165 LYS A CB 1 ATOM 1297 C CG . LYS A 1 164 ? -5.502 34.919 -14.485 1.00 102.13 ? 165 LYS A CG 1 ATOM 1298 C CD . LYS A 1 164 ? -5.262 34.303 -15.861 1.00 96.97 ? 165 LYS A CD 1 ATOM 1299 C CE . LYS A 1 164 ? -4.744 35.356 -16.830 1.00 103.62 ? 165 LYS A CE 1 ATOM 1300 N NZ . LYS A 1 164 ? -5.701 36.495 -17.004 1.00 108.25 ? 165 LYS A NZ 1 ATOM 1301 N N . VAL A 1 165 ? -9.511 32.554 -12.553 1.00 90.55 ? 166 VAL A N 1 ATOM 1302 C CA . VAL A 1 165 ? -10.180 31.612 -11.652 1.00 76.45 ? 166 VAL A CA 1 ATOM 1303 C C . VAL A 1 165 ? -11.253 30.796 -12.399 1.00 73.16 ? 166 VAL A C 1 ATOM 1304 O O . VAL A 1 165 ? -11.837 31.275 -13.377 1.00 61.36 ? 166 VAL A O 1 ATOM 1305 C CB . VAL A 1 165 ? -10.676 32.343 -10.382 1.00 68.13 ? 166 VAL A CB 1 ATOM 1306 C CG1 . VAL A 1 165 ? -12.172 32.619 -10.404 1.00 59.45 ? 166 VAL A CG1 1 ATOM 1307 C CG2 . VAL A 1 165 ? -10.262 31.567 -9.157 1.00 63.50 ? 166 VAL A CG2 1 ATOM 1308 N N . VAL A 1 166 ? -11.462 29.546 -11.971 1.00 77.15 ? 167 VAL A N 1 ATOM 1309 C CA . VAL A 1 166 ? -12.502 28.661 -12.573 1.00 75.00 ? 167 VAL A CA 1 ATOM 1310 C C . VAL A 1 166 ? -13.444 28.019 -11.543 1.00 70.03 ? 167 VAL A C 1 ATOM 1311 O O . VAL A 1 166 ? -12.998 27.448 -10.534 1.00 63.90 ? 167 VAL A O 1 ATOM 1312 C CB . VAL A 1 166 ? -11.933 27.582 -13.540 1.00 72.36 ? 167 VAL A CB 1 ATOM 1313 C CG1 . VAL A 1 166 ? -11.248 28.231 -14.732 1.00 71.57 ? 167 VAL A CG1 1 ATOM 1314 C CG2 . VAL A 1 166 ? -10.982 26.629 -12.833 1.00 70.79 ? 167 VAL A CG2 1 ATOM 1315 N N . SER A 1 167 ? -14.743 28.125 -11.817 1.00 67.20 ? 168 SER A N 1 ATOM 1316 C CA . SER A 1 167 ? -15.788 27.615 -10.923 1.00 65.32 ? 168 SER A CA 1 ATOM 1317 C C . SER A 1 167 ? -16.590 26.484 -11.562 1.00 60.74 ? 168 SER A C 1 ATOM 1318 O O . SER A 1 167 ? -16.574 26.334 -12.775 1.00 65.05 ? 168 SER A O 1 ATOM 1319 C CB . SER A 1 167 ? -16.712 28.753 -10.486 1.00 66.61 ? 168 SER A CB 1 ATOM 1320 O OG . SER A 1 167 ? -16.103 29.548 -9.469 1.00 73.07 ? 168 SER A OG 1 ATOM 1321 N N . GLY A 1 168 ? -17.272 25.681 -10.745 1.00 60.39 ? 169 GLY A N 1 ATOM 1322 C CA . GLY A 1 168 ? -18.130 24.579 -11.236 1.00 61.20 ? 169 GLY A CA 1 ATOM 1323 C C . GLY A 1 168 ? -18.902 23.821 -10.160 1.00 61.29 ? 169 GLY A C 1 ATOM 1324 O O . GLY A 1 168 ? -18.610 23.942 -8.967 1.00 58.98 ? 169 GLY A O 1 ATOM 1325 N N . PHE A 1 169 ? -19.889 23.025 -10.567 1.00 59.54 ? 170 PHE A N 1 ATOM 1326 C CA . PHE A 1 169 ? -20.721 22.347 -9.570 1.00 52.42 ? 170 PHE A CA 1 ATOM 1327 C C . PHE A 1 169 ? -20.285 20.934 -9.331 1.00 53.92 ? 170 PHE A C 1 ATOM 1328 O O . PHE A 1 169 ? -19.636 20.341 -10.175 1.00 67.06 ? 170 PHE A O 1 ATOM 1329 C CB . PHE A 1 169 ? -22.175 22.330 -10.000 1.00 47.07 ? 170 PHE A CB 1 ATOM 1330 C CG . PHE A 1 169 ? -22.817 23.676 -10.037 1.00 38.48 ? 170 PHE A CG 1 ATOM 1331 C CD1 . PHE A 1 169 ? -23.235 24.301 -8.866 1.00 38.66 ? 170 PHE A CD1 1 ATOM 1332 C CD2 . PHE A 1 169 ? -23.026 24.310 -11.237 1.00 37.02 ? 170 PHE A CD2 1 ATOM 1333 C CE1 . PHE A 1 169 ? -23.863 25.557 -8.888 1.00 38.41 ? 170 PHE A CE1 1 ATOM 1334 C CE2 . PHE A 1 169 ? -23.651 25.569 -11.277 1.00 42.30 ? 170 PHE A CE2 1 ATOM 1335 C CZ . PHE A 1 169 ? -24.070 26.201 -10.098 1.00 37.96 ? 170 PHE A CZ 1 ATOM 1336 N N . SER A 1 170 ? -20.664 20.401 -8.176 1.00 60.52 ? 171 SER A N 1 ATOM 1337 C CA . SER A 1 170 ? -20.553 18.976 -7.854 1.00 61.37 ? 171 SER A CA 1 ATOM 1338 C C . SER A 1 170 ? -21.173 18.152 -8.988 1.00 63.65 ? 171 SER A C 1 ATOM 1339 O O . SER A 1 170 ? -22.150 18.581 -9.635 1.00 67.21 ? 171 SER A O 1 ATOM 1340 C CB . SER A 1 170 ? -21.268 18.695 -6.523 1.00 54.95 ? 171 SER A CB 1 ATOM 1341 O OG . SER A 1 170 ? -20.970 17.408 -6.024 1.00 51.46 ? 171 SER A OG 1 ATOM 1342 N N . LEU A 1 171 ? -20.585 16.998 -9.266 1.00 58.88 ? 172 LEU A N 1 ATOM 1343 C CA . LEU A 1 171 ? -21.123 16.152 -10.323 1.00 58.92 ? 172 LEU A CA 1 ATOM 1344 C C . LEU A 1 171 ? -21.715 14.845 -9.784 1.00 60.28 ? 172 LEU A C 1 ATOM 1345 O O . LEU A 1 171 ? -21.670 13.806 -10.455 1.00 56.38 ? 172 LEU A O 1 ATOM 1346 C CB . LEU A 1 171 ? -20.055 15.845 -11.351 1.00 60.80 ? 172 LEU A CB 1 ATOM 1347 C CG . LEU A 1 171 ? -19.249 16.885 -12.116 1.00 62.47 ? 172 LEU A CG 1 ATOM 1348 C CD1 . LEU A 1 171 ? -18.176 16.075 -12.838 1.00 62.57 ? 172 LEU A CD1 1 ATOM 1349 C CD2 . LEU A 1 171 ? -20.068 17.717 -13.095 1.00 60.44 ? 172 LEU A CD2 1 ATOM 1350 N N . LYS A 1 172 ? -22.251 14.914 -8.564 1.00 60.90 ? 173 LYS A N 1 ATOM 1351 C CA . LYS A 1 172 ? -22.933 13.804 -7.930 1.00 58.23 ? 173 LYS A CA 1 ATOM 1352 C C . LYS A 1 172 ? -24.147 13.418 -8.766 1.00 63.32 ? 173 LYS A C 1 ATOM 1353 O O . LYS A 1 172 ? -24.512 12.223 -8.831 1.00 68.64 ? 173 LYS A O 1 ATOM 1354 C CB . LYS A 1 172 ? -23.381 14.187 -6.512 1.00 56.76 ? 173 LYS A CB 1 ATOM 1355 C CG . LYS A 1 172 ? -22.259 14.178 -5.490 1.00 56.98 ? 173 LYS A CG 1 ATOM 1356 C CD . LYS A 1 172 ? -22.722 14.393 -4.044 1.00 51.66 ? 173 LYS A CD 1 ATOM 1357 C CE . LYS A 1 172 ? -21.551 14.891 -3.189 1.00 51.05 ? 173 LYS A CE 1 ATOM 1358 N NZ . LYS A 1 172 ? -20.788 16.115 -3.679 1.00 49.06 ? 173 LYS A NZ 1 ATOM 1359 N N . SER A 1 173 ? -24.762 14.420 -9.406 1.00 55.20 ? 174 SER A N 1 ATOM 1360 C CA . SER A 1 173 ? -25.960 14.178 -10.183 1.00 59.88 ? 174 SER A CA 1 ATOM 1361 C C . SER A 1 173 ? -25.605 13.857 -11.634 1.00 64.11 ? 174 SER A C 1 ATOM 1362 O O . SER A 1 173 ? -26.427 14.010 -12.547 1.00 69.92 ? 174 SER A O 1 ATOM 1363 C CB . SER A 1 173 ? -26.932 15.350 -10.077 1.00 61.29 ? 174 SER A CB 1 ATOM 1364 O OG . SER A 1 173 ? -26.568 16.386 -10.975 1.00 73.59 ? 174 SER A OG 1 ATOM 1365 N N . CYS A 1 174 ? -24.366 13.425 -11.838 1.00 65.69 ? 175 CYS A N 1 ATOM 1366 C CA . CYS A 1 174 ? -23.939 12.820 -13.102 1.00 64.77 ? 175 CYS A CA 1 ATOM 1367 C C . CYS A 1 174 ? -23.542 11.368 -12.890 1.00 60.66 ? 175 CYS A C 1 ATOM 1368 O O . CYS A 1 174 ? -22.982 10.726 -13.776 1.00 66.21 ? 175 CYS A O 1 ATOM 1369 C CB . CYS A 1 174 ? -22.811 13.626 -13.716 1.00 65.30 ? 175 CYS A CB 1 ATOM 1370 S SG . CYS A 1 174 ? -23.266 15.355 -13.660 1.00 75.43 ? 175 CYS A SG 1 ATOM 1371 N N . ALA A 1 175 ? -23.886 10.865 -11.707 1.00 53.95 ? 176 ALA A N 1 ATOM 1372 C CA . ALA A 1 175 ? -23.562 9.537 -11.247 1.00 49.07 ? 176 ALA A CA 1 ATOM 1373 C C . ALA A 1 175 ? -22.071 9.319 -11.207 1.00 48.67 ? 176 ALA A C 1 ATOM 1374 O O . ALA A 1 175 ? -21.614 8.202 -11.370 1.00 51.39 ? 176 ALA A O 1 ATOM 1375 C CB . ALA A 1 175 ? -24.254 8.494 -12.106 1.00 47.45 ? 176 ALA A CB 1 ATOM 1376 N N . LEU A 1 176 ? -21.313 10.378 -10.953 1.00 50.72 ? 177 LEU A N 1 ATOM 1377 C CA . LEU A 1 176 ? -19.848 10.278 -10.968 1.00 55.28 ? 177 LEU A CA 1 ATOM 1378 C C . LEU A 1 176 ? -19.149 10.164 -9.615 1.00 57.22 ? 177 LEU A C 1 ATOM 1379 O O . LEU A 1 176 ? -17.968 9.873 -9.566 1.00 65.75 ? 177 LEU A O 1 ATOM 1380 C CB . LEU A 1 176 ? -19.231 11.414 -11.786 1.00 54.05 ? 177 LEU A CB 1 ATOM 1381 C CG . LEU A 1 176 ? -19.348 11.283 -13.309 1.00 52.55 ? 177 LEU A CG 1 ATOM 1382 C CD1 . LEU A 1 176 ? -19.044 12.612 -13.978 1.00 50.48 ? 177 LEU A CD1 1 ATOM 1383 C CD2 . LEU A 1 176 ? -18.438 10.186 -13.842 1.00 54.25 ? 177 LEU A CD2 1 ATOM 1384 N N . SER A 1 177 ? -19.866 10.377 -8.521 1.00 59.92 ? 178 SER A N 1 ATOM 1385 C CA . SER A 1 177 ? -19.242 10.394 -7.198 1.00 59.30 ? 178 SER A CA 1 ATOM 1386 C C . SER A 1 177 ? -18.858 8.998 -6.769 1.00 58.39 ? 178 SER A C 1 ATOM 1387 O O . SER A 1 177 ? -19.493 8.058 -7.199 1.00 68.31 ? 178 SER A O 1 ATOM 1388 C CB . SER A 1 177 ? -20.222 10.972 -6.193 1.00 59.53 ? 178 SER A CB 1 ATOM 1389 O OG . SER A 1 177 ? -19.608 11.123 -4.935 1.00 56.89 ? 178 SER A OG 1 ATOM 1390 N N . ASN A 1 178 ? -17.830 8.859 -5.932 1.00 61.81 ? 179 ASN A N 1 ATOM 1391 C CA . ASN A 1 178 ? -17.498 7.553 -5.319 1.00 64.98 ? 179 ASN A CA 1 ATOM 1392 C C . ASN A 1 178 ? -17.816 7.557 -3.850 1.00 64.28 ? 179 ASN A C 1 ATOM 1393 O O . ASN A 1 178 ? -17.366 6.678 -3.110 1.00 70.44 ? 179 ASN A O 1 ATOM 1394 C CB . ASN A 1 178 ? -16.030 7.143 -5.500 1.00 65.22 ? 179 ASN A CB 1 ATOM 1395 C CG . ASN A 1 178 ? -15.474 7.545 -6.831 1.00 64.63 ? 179 ASN A CG 1 ATOM 1396 O OD1 . ASN A 1 178 ? -15.673 6.864 -7.832 1.00 64.17 ? 179 ASN A OD1 1 ATOM 1397 N ND2 . ASN A 1 178 ? -14.782 8.672 -6.853 1.00 62.39 ? 179 ASN A ND2 1 ATOM 1398 N N . LEU A 1 179 ? -18.581 8.564 -3.439 1.00 64.41 ? 180 LEU A N 1 ATOM 1399 C CA . LEU A 1 179 ? -19.063 8.703 -2.075 1.00 61.93 ? 180 LEU A CA 1 ATOM 1400 C C . LEU A 1 179 ? -20.010 7.533 -1.817 1.00 63.36 ? 180 LEU A C 1 ATOM 1401 O O . LEU A 1 179 ? -20.878 7.269 -2.639 1.00 60.85 ? 180 LEU A O 1 ATOM 1402 C CB . LEU A 1 179 ? -19.760 10.063 -1.906 1.00 57.22 ? 180 LEU A CB 1 ATOM 1403 C CG . LEU A 1 179 ? -20.051 10.560 -0.494 1.00 63.89 ? 180 LEU A CG 1 ATOM 1404 C CD1 . LEU A 1 179 ? -18.794 11.068 0.181 1.00 68.89 ? 180 LEU A CD1 1 ATOM 1405 C CD2 . LEU A 1 179 ? -21.111 11.647 -0.468 1.00 72.43 ? 180 LEU A CD2 1 ATOM 1406 N N . ALA A 1 180 ? -19.825 6.807 -0.712 1.00 66.00 ? 181 ALA A N 1 ATOM 1407 C CA . ALA A 1 180 ? -20.688 5.654 -0.441 1.00 62.59 ? 181 ALA A CA 1 ATOM 1408 C C . ALA A 1 180 ? -22.031 6.109 0.125 1.00 62.53 ? 181 ALA A C 1 ATOM 1409 O O . ALA A 1 180 ? -22.061 6.844 1.100 1.00 64.82 ? 181 ALA A O 1 ATOM 1410 C CB . ALA A 1 180 ? -19.999 4.672 0.477 1.00 56.16 ? 181 ALA A CB 1 ATOM 1411 N N . CYS A 1 181 ? -23.123 5.716 -0.536 1.00 66.39 ? 182 CYS A N 1 ATOM 1412 C CA . CYS A 1 181 ? -24.494 5.873 -0.021 1.00 69.43 ? 182 CYS A CA 1 ATOM 1413 C C . CYS A 1 181 ? -24.707 4.930 1.135 1.00 71.22 ? 182 CYS A C 1 ATOM 1414 O O . CYS A 1 181 ? -24.290 3.773 1.058 1.00 81.79 ? 182 CYS A O 1 ATOM 1415 C CB . CYS A 1 181 ? -25.517 5.526 -1.096 1.00 73.43 ? 182 CYS A CB 1 ATOM 1416 S SG . CYS A 1 181 ? -25.130 6.327 -2.660 1.00 109.49 ? 182 CYS A SG 1 ATOM 1417 N N . ILE A 1 182 ? -25.350 5.419 2.199 1.00 69.69 ? 183 ILE A N 1 ATOM 1418 C CA . ILE A 1 182 ? -25.801 4.575 3.327 1.00 62.20 ? 183 ILE A CA 1 ATOM 1419 C C . ILE A 1 182 ? -27.311 4.330 3.236 1.00 61.05 ? 183 ILE A C 1 ATOM 1420 O O . ILE A 1 182 ? -28.098 5.249 3.412 1.00 60.08 ? 183 ILE A O 1 ATOM 1421 C CB . ILE A 1 182 ? -25.443 5.212 4.679 1.00 61.85 ? 183 ILE A CB 1 ATOM 1422 C CG1 . ILE A 1 182 ? -23.914 5.380 4.780 1.00 58.63 ? 183 ILE A CG1 1 ATOM 1423 C CG2 . ILE A 1 182 ? -26.097 4.448 5.847 1.00 61.09 ? 183 ILE A CG2 1 ATOM 1424 C CD1 . ILE A 1 182 ? -23.466 6.344 5.863 1.00 60.39 ? 183 ILE A CD1 1 ATOM 1425 N N . ARG A 1 183 ? -27.714 3.096 2.951 1.00 64.46 ? 184 ARG A N 1 ATOM 1426 C CA . ARG A 1 183 ? -29.136 2.827 2.696 1.00 66.01 ? 184 ARG A CA 1 ATOM 1427 C C . ARG A 1 183 ? -29.912 2.410 3.934 1.00 70.31 ? 184 ARG A C 1 ATOM 1428 O O . ARG A 1 183 ? -31.138 2.297 3.875 1.00 59.84 ? 184 ARG A O 1 ATOM 1429 C CB . ARG A 1 183 ? -29.334 1.800 1.595 1.00 59.50 ? 184 ARG A CB 1 ATOM 1430 C CG . ARG A 1 183 ? -29.140 2.356 0.219 1.00 62.54 ? 184 ARG A CG 1 ATOM 1431 C CD . ARG A 1 183 ? -29.089 1.228 -0.786 1.00 68.48 ? 184 ARG A CD 1 ATOM 1432 N NE . ARG A 1 183 ? -28.593 1.680 -2.088 1.00 70.19 ? 184 ARG A NE 1 ATOM 1433 C CZ . ARG A 1 183 ? -29.358 1.868 -3.160 1.00 74.64 ? 184 ARG A CZ 1 ATOM 1434 N NH1 . ARG A 1 183 ? -30.668 1.641 -3.111 1.00 72.62 ? 184 ARG A NH1 1 ATOM 1435 N NH2 . ARG A 1 183 ? -28.811 2.294 -4.285 1.00 80.95 ? 184 ARG A NH2 1 ATOM 1436 N N . ASP A 1 184 ? -29.194 2.202 5.043 1.00 78.58 ? 185 ASP A N 1 ATOM 1437 C CA . ASP A 1 184 ? -29.782 1.701 6.284 1.00 83.93 ? 185 ASP A CA 1 ATOM 1438 C C . ASP A 1 184 ? -30.744 2.699 6.912 1.00 84.05 ? 185 ASP A C 1 ATOM 1439 O O . ASP A 1 184 ? -30.399 3.866 7.122 1.00 93.42 ? 185 ASP A O 1 ATOM 1440 C CB . ASP A 1 184 ? -28.688 1.318 7.281 1.00 90.18 ? 185 ASP A CB 1 ATOM 1441 C CG . ASP A 1 184 ? -27.774 0.212 6.761 1.00 99.32 ? 185 ASP A CG 1 ATOM 1442 O OD1 . ASP A 1 184 ? -28.267 -0.894 6.422 1.00 90.97 ? 185 ASP A OD1 1 ATOM 1443 O OD2 . ASP A 1 184 ? -26.546 0.456 6.706 1.00 113.42 ? 185 ASP A OD2 1 ATOM 1444 N N . ILE A 1 185 ? -31.959 2.230 7.177 1.00 80.98 ? 186 ILE A N 1 ATOM 1445 C CA . ILE A 1 185 ? -32.958 3.023 7.884 1.00 84.31 ? 186 ILE A CA 1 ATOM 1446 C C . ILE A 1 185 ? -33.116 2.584 9.364 1.00 86.61 ? 186 ILE A C 1 ATOM 1447 O O . ILE A 1 185 ? -33.718 1.558 9.676 1.00 84.14 ? 186 ILE A O 1 ATOM 1448 C CB . ILE A 1 185 ? -34.284 3.125 7.088 1.00 82.58 ? 186 ILE A CB 1 ATOM 1449 C CG1 . ILE A 1 185 ? -34.100 4.114 5.915 1.00 84.46 ? 186 ILE A CG1 1 ATOM 1450 C CG2 . ILE A 1 185 ? -35.431 3.573 7.993 1.00 94.81 ? 186 ILE A CG2 1 ATOM 1451 C CD1 . ILE A 1 185 ? -35.286 4.315 4.966 1.00 82.87 ? 186 ILE A CD1 1 ATOM 1452 N N . PHE A 1 186 ? -32.546 3.388 10.256 1.00 86.64 ? 187 PHE A N 1 ATOM 1453 C CA . PHE A 1 186 ? -32.559 3.166 11.696 1.00 82.72 ? 187 PHE A CA 1 ATOM 1454 C C . PHE A 1 186 ? -33.947 3.449 12.317 1.00 79.07 ? 187 PHE A C 1 ATOM 1455 O O . PHE A 1 186 ? -34.375 4.607 12.381 1.00 77.52 ? 187 PHE A O 1 ATOM 1456 C CB . PHE A 1 186 ? -31.501 4.071 12.334 1.00 89.70 ? 187 PHE A CB 1 ATOM 1457 C CG . PHE A 1 186 ? -30.075 3.702 12.002 1.00 101.63 ? 187 PHE A CG 1 ATOM 1458 C CD1 . PHE A 1 186 ? -29.500 4.067 10.781 1.00 101.15 ? 187 PHE A CD1 1 ATOM 1459 C CD2 . PHE A 1 186 ? -29.280 3.019 12.947 1.00 118.14 ? 187 PHE A CD2 1 ATOM 1460 C CE1 . PHE A 1 186 ? -28.177 3.735 10.496 1.00 115.46 ? 187 PHE A CE1 1 ATOM 1461 C CE2 . PHE A 1 186 ? -27.954 2.689 12.670 1.00 120.65 ? 187 PHE A CE2 1 ATOM 1462 C CZ . PHE A 1 186 ? -27.402 3.050 11.441 1.00 121.77 ? 187 PHE A CZ 1 ATOM 1463 N N . PRO A 1 187 ? -34.666 2.400 12.771 1.00 73.98 ? 188 PRO A N 1 ATOM 1464 C CA . PRO A 1 187 ? -35.977 2.642 13.400 1.00 69.88 ? 188 PRO A CA 1 ATOM 1465 C C . PRO A 1 187 ? -35.874 2.903 14.909 1.00 74.96 ? 188 PRO A C 1 ATOM 1466 O O . PRO A 1 187 ? -34.830 2.633 15.509 1.00 85.28 ? 188 PRO A O 1 ATOM 1467 C CB . PRO A 1 187 ? -36.734 1.355 13.122 1.00 64.57 ? 188 PRO A CB 1 ATOM 1468 C CG . PRO A 1 187 ? -35.674 0.314 12.919 1.00 70.45 ? 188 PRO A CG 1 ATOM 1469 C CD . PRO A 1 187 ? -34.333 0.967 12.746 1.00 67.56 ? 188 PRO A CD 1 ATOM 1470 N N . ASN A 1 188 ? -36.939 3.445 15.502 1.00 82.55 ? 189 ASN A N 1 ATOM 1471 C CA . ASN A 1 188 ? -36.985 3.864 16.930 1.00 88.44 ? 189 ASN A CA 1 ATOM 1472 C C . ASN A 1 188 ? -35.853 4.772 17.445 1.00 91.59 ? 189 ASN A C 1 ATOM 1473 O O . ASN A 1 188 ? -35.705 4.990 18.659 1.00 103.35 ? 189 ASN A O 1 ATOM 1474 C CB . ASN A 1 188 ? -37.176 2.652 17.846 1.00 83.25 ? 189 ASN A CB 1 ATOM 1475 C CG . ASN A 1 188 ? -38.565 2.082 17.756 1.00 78.62 ? 189 ASN A CG 1 ATOM 1476 O OD1 . ASN A 1 188 ? -38.748 0.900 17.481 1.00 82.02 ? 189 ASN A OD1 1 ATOM 1477 N ND2 . ASN A 1 188 ? -39.555 2.922 17.965 1.00 72.43 ? 189 ASN A ND2 1 ATOM 1478 N N . THR A 1 189 ? -35.080 5.308 16.508 1.00 78.47 ? 190 THR A N 1 ATOM 1479 C CA . THR A 1 189 ? -33.973 6.184 16.808 1.00 75.54 ? 190 THR A CA 1 ATOM 1480 C C . THR A 1 189 ? -34.307 7.542 16.254 1.00 71.43 ? 190 THR A C 1 ATOM 1481 O O . THR A 1 189 ? -35.020 7.648 15.275 1.00 73.31 ? 190 THR A O 1 ATOM 1482 C CB . THR A 1 189 ? -32.683 5.711 16.125 1.00 85.38 ? 190 THR A CB 1 ATOM 1483 O OG1 . THR A 1 189 ? -32.986 5.375 14.771 1.00 96.71 ? 190 THR A OG1 1 ATOM 1484 C CG2 . THR A 1 189 ? -32.069 4.471 16.825 1.00 96.88 ? 190 THR A CG2 1 ATOM 1485 N N . VAL A 1 190 ? -33.803 8.585 16.892 1.00 74.74 ? 191 VAL A N 1 ATOM 1486 C CA . VAL A 1 190 ? -33.852 9.939 16.330 1.00 80.41 ? 191 VAL A CA 1 ATOM 1487 C C . VAL A 1 190 ? -32.404 10.437 16.163 1.00 89.19 ? 191 VAL A C 1 ATOM 1488 O O . VAL A 1 190 ? -31.469 9.817 16.709 1.00 94.92 ? 191 VAL A O 1 ATOM 1489 C CB . VAL A 1 190 ? -34.704 10.928 17.185 1.00 78.89 ? 191 VAL A CB 1 ATOM 1490 C CG1 . VAL A 1 190 ? -36.115 10.418 17.429 1.00 77.77 ? 191 VAL A CG1 1 ATOM 1491 C CG2 . VAL A 1 190 ? -34.054 11.201 18.521 1.00 86.15 ? 191 VAL A CG2 1 ATOM 1492 N N . PHE A 1 191 ? -32.211 11.516 15.396 1.00 84.06 ? 192 PHE A N 1 ATOM 1493 C CA . PHE A 1 191 ? -30.901 12.181 15.339 1.00 85.77 ? 192 PHE A CA 1 ATOM 1494 C C . PHE A 1 191 ? -30.970 13.572 15.899 1.00 87.97 ? 192 PHE A C 1 ATOM 1495 O O . PHE A 1 191 ? -31.997 14.245 15.788 1.00 86.15 ? 192 PHE A O 1 ATOM 1496 C CB . PHE A 1 191 ? -30.334 12.247 13.922 1.00 81.94 ? 192 PHE A CB 1 ATOM 1497 C CG . PHE A 1 191 ? -29.951 10.921 13.366 1.00 78.07 ? 192 PHE A CG 1 ATOM 1498 C CD1 . PHE A 1 191 ? -29.311 9.966 14.164 1.00 80.73 ? 192 PHE A CD1 1 ATOM 1499 C CD2 . PHE A 1 191 ? -30.222 10.623 12.042 1.00 75.62 ? 192 PHE A CD2 1 ATOM 1500 C CE1 . PHE A 1 191 ? -28.960 8.736 13.647 1.00 81.07 ? 192 PHE A CE1 1 ATOM 1501 C CE2 . PHE A 1 191 ? -29.879 9.398 11.517 1.00 75.42 ? 192 PHE A CE2 1 ATOM 1502 C CZ . PHE A 1 191 ? -29.249 8.450 12.322 1.00 82.62 ? 192 PHE A CZ 1 ATOM 1503 N N . ALA A 1 192 ? -29.865 14.010 16.482 1.00 88.96 ? 193 ALA A N 1 ATOM 1504 C CA . ALA A 1 192 ? -29.837 15.308 17.102 1.00 89.19 ? 193 ALA A CA 1 ATOM 1505 C C . ALA A 1 192 ? -28.622 16.064 16.625 1.00 92.37 ? 193 ALA A C 1 ATOM 1506 O O . ALA A 1 192 ? -27.541 15.977 17.229 1.00 102.11 ? 193 ALA A O 1 ATOM 1507 C CB . ALA A 1 192 ? -29.839 15.160 18.618 1.00 94.48 ? 193 ALA A CB 1 ATOM 1508 N N . ASP A 1 193 ? -28.784 16.767 15.510 1.00 78.27 ? 194 ASP A N 1 ATOM 1509 C CA . ASP A 1 193 ? -27.762 17.702 15.051 1.00 76.55 ? 194 ASP A CA 1 ATOM 1510 C C . ASP A 1 193 ? -28.501 18.948 14.555 1.00 80.12 ? 194 ASP A C 1 ATOM 1511 O O . ASP A 1 193 ? -29.568 19.258 15.095 1.00 94.06 ? 194 ASP A O 1 ATOM 1512 C CB . ASP A 1 193 ? -26.807 17.054 14.033 1.00 73.68 ? 194 ASP A CB 1 ATOM 1513 C CG . ASP A 1 193 ? -25.876 15.997 14.678 1.00 82.87 ? 194 ASP A CG 1 ATOM 1514 O OD1 . ASP A 1 193 ? -24.728 16.352 15.024 1.00 87.37 ? 194 ASP A OD1 1 ATOM 1515 O OD2 . ASP A 1 193 ? -26.284 14.817 14.866 1.00 82.67 ? 194 ASP A OD2 1 ATOM 1516 N N . SER A 1 194 ? -27.966 19.664 13.569 1.00 71.31 ? 195 SER A N 1 ATOM 1517 C CA . SER A 1 194 ? -28.635 20.856 13.033 1.00 71.64 ? 195 SER A CA 1 ATOM 1518 C C . SER A 1 194 ? -29.948 20.565 12.332 1.00 73.36 ? 195 SER A C 1 ATOM 1519 O O . SER A 1 194 ? -30.106 19.515 11.731 1.00 82.50 ? 195 SER A O 1 ATOM 1520 C CB . SER A 1 194 ? -27.723 21.553 12.055 1.00 75.10 ? 195 SER A CB 1 ATOM 1521 O OG . SER A 1 194 ? -26.561 21.947 12.741 1.00 95.42 ? 195 SER A OG 1 ATOM 1522 N N . ASN A 1 195 ? -30.890 21.493 12.401 1.00 73.03 ? 196 ASN A N 1 ATOM 1523 C CA . ASN A 1 195 ? -32.166 21.294 11.729 1.00 73.44 ? 196 ASN A CA 1 ATOM 1524 C C . ASN A 1 195 ? -32.396 22.328 10.660 1.00 76.08 ? 196 ASN A C 1 ATOM 1525 O O . ASN A 1 195 ? -32.864 23.440 10.945 1.00 86.07 ? 196 ASN A O 1 ATOM 1526 C CB . ASN A 1 195 ? -33.309 21.220 12.740 1.00 73.11 ? 196 ASN A CB 1 ATOM 1527 C CG . ASN A 1 195 ? -33.454 19.837 13.312 1.00 73.66 ? 196 ASN A CG 1 ATOM 1528 O OD1 . ASN A 1 195 ? -33.952 18.947 12.636 1.00 83.30 ? 196 ASN A OD1 1 ATOM 1529 N ND2 . ASN A 1 195 ? -32.970 19.629 14.535 1.00 67.38 ? 196 ASN A ND2 1 ATOM 1530 N N . ILE A 1 196 ? -32.052 21.954 9.428 1.00 68.40 ? 197 ILE A N 1 ATOM 1531 C CA . ILE A 1 196 ? -31.955 22.922 8.333 1.00 59.72 ? 197 ILE A CA 1 ATOM 1532 C C . ILE A 1 196 ? -33.238 23.103 7.583 1.00 56.35 ? 197 ILE A C 1 ATOM 1533 O O . ILE A 1 196 ? -33.324 23.991 6.758 1.00 62.46 ? 197 ILE A O 1 ATOM 1534 C CB . ILE A 1 196 ? -30.815 22.603 7.352 1.00 57.81 ? 197 ILE A CB 1 ATOM 1535 C CG1 . ILE A 1 196 ? -31.081 21.332 6.554 1.00 66.87 ? 197 ILE A CG1 1 ATOM 1536 C CG2 . ILE A 1 196 ? -29.538 22.406 8.117 1.00 59.90 ? 197 ILE A CG2 1 ATOM 1537 C CD1 . ILE A 1 196 ? -31.517 21.568 5.127 1.00 71.72 ? 197 ILE A CD1 1 ATOM 1538 N N . ASP A 1 197 ? -34.214 22.241 7.847 1.00 54.45 ? 198 ASP A N 1 ATOM 1539 C CA . ASP A 1 197 ? -35.505 22.295 7.163 1.00 55.32 ? 198 ASP A CA 1 ATOM 1540 C C . ASP A 1 197 ? -36.421 21.191 7.623 1.00 50.60 ? 198 ASP A C 1 ATOM 1541 O O . ASP A 1 197 ? -35.969 20.246 8.276 1.00 53.48 ? 198 ASP A O 1 ATOM 1542 C CB . ASP A 1 197 ? -35.330 22.157 5.659 1.00 61.08 ? 198 ASP A CB 1 ATOM 1543 C CG . ASP A 1 197 ? -36.309 22.980 4.901 1.00 69.56 ? 198 ASP A CG 1 ATOM 1544 O OD1 . ASP A 1 197 ? -37.337 23.385 5.484 1.00 69.99 ? 198 ASP A OD1 1 ATOM 1545 O OD2 . ASP A 1 197 ? -36.051 23.227 3.707 1.00 85.54 ? 198 ASP A OD2 1 ATOM 1546 N N . SER A 1 198 ? -37.704 21.311 7.284 1.00 45.17 ? 199 SER A N 1 ATOM 1547 C CA . SER A 1 198 ? -38.678 20.282 7.613 1.00 46.76 ? 199 SER A CA 1 ATOM 1548 C C . SER A 1 198 ? -39.844 20.269 6.669 1.00 49.20 ? 199 SER A C 1 ATOM 1549 O O . SER A 1 198 ? -40.345 21.330 6.312 1.00 48.97 ? 199 SER A O 1 ATOM 1550 C CB . SER A 1 198 ? -39.226 20.496 9.000 1.00 46.32 ? 199 SER A CB 1 ATOM 1551 O OG . SER A 1 198 ? -40.220 21.478 8.927 1.00 48.58 ? 199 SER A OG 1 ATOM 1552 N N . VAL A 1 199 ? -40.285 19.073 6.276 1.00 54.07 ? 200 VAL A N 1 ATOM 1553 C CA . VAL A 1 199 ? -41.582 18.950 5.582 1.00 64.85 ? 200 VAL A CA 1 ATOM 1554 C C . VAL A 1 199 ? -42.511 17.951 6.256 1.00 63.43 ? 200 VAL A C 1 ATOM 1555 O O . VAL A 1 199 ? -42.105 17.241 7.182 1.00 68.74 ? 200 VAL A O 1 ATOM 1556 C CB . VAL A 1 199 ? -41.460 18.613 4.078 1.00 67.25 ? 200 VAL A CB 1 ATOM 1557 C CG1 . VAL A 1 199 ? -40.657 19.688 3.346 1.00 71.75 ? 200 VAL A CG1 1 ATOM 1558 C CG2 . VAL A 1 199 ? -40.863 17.225 3.888 1.00 67.92 ? 200 VAL A CG2 1 ATOM 1559 N N . MET A 1 200 ? -43.752 17.925 5.784 1.00 56.61 ? 201 MET A N 1 ATOM 1560 C CA . MET A 1 200 ? -44.717 16.909 6.161 1.00 54.44 ? 201 MET A CA 1 ATOM 1561 C C . MET A 1 200 ? -44.679 15.736 5.153 1.00 56.65 ? 201 MET A C 1 ATOM 1562 O O . MET A 1 200 ? -44.957 15.909 3.957 1.00 63.62 ? 201 MET A O 1 ATOM 1563 C CB . MET A 1 200 ? -46.096 17.555 6.257 1.00 52.24 ? 201 MET A CB 1 ATOM 1564 C CG . MET A 1 200 ? -46.181 18.586 7.365 1.00 53.31 ? 201 MET A CG 1 ATOM 1565 S SD . MET A 1 200 ? -46.000 17.892 9.029 1.00 60.28 ? 201 MET A SD 1 ATOM 1566 C CE . MET A 1 200 ? -47.675 17.197 9.208 1.00 58.47 ? 201 MET A CE 1 ATOM 1567 N N . ALA A 1 201 ? -44.296 14.551 5.620 1.00 54.67 ? 202 ALA A N 1 ATOM 1568 C CA . ALA A 1 201 ? -44.185 13.362 4.748 1.00 54.53 ? 202 ALA A CA 1 ATOM 1569 C C . ALA A 1 201 ? -45.144 12.280 5.226 1.00 56.28 ? 202 ALA A C 1 ATOM 1570 O O . ALA A 1 201 ? -45.372 12.146 6.426 1.00 61.59 ? 202 ALA A O 1 ATOM 1571 C CB . ALA A 1 201 ? -42.749 12.829 4.711 1.00 48.66 ? 202 ALA A CB 1 ATOM 1572 N N . PRO A 1 202 ? -45.732 11.518 4.300 1.00 54.40 ? 203 PRO A N 1 ATOM 1573 C CA . PRO A 1 202 ? -46.637 10.457 4.710 1.00 53.84 ? 203 PRO A CA 1 ATOM 1574 C C . PRO A 1 202 ? -45.937 9.211 5.237 1.00 57.01 ? 203 PRO A C 1 ATOM 1575 O O . PRO A 1 202 ? -46.505 8.530 6.081 1.00 63.31 ? 203 PRO A O 1 ATOM 1576 C CB . PRO A 1 202 ? -47.405 10.160 3.448 1.00 55.75 ? 203 PRO A CB 1 ATOM 1577 C CG . PRO A 1 202 ? -46.453 10.517 2.360 1.00 59.19 ? 203 PRO A CG 1 ATOM 1578 C CD . PRO A 1 202 ? -45.781 11.746 2.856 1.00 57.04 ? 203 PRO A CD 1 ATOM 1579 N N . ASP A 1 203 ? -44.731 8.915 4.758 1.00 59.88 ? 204 ASP A N 1 ATOM 1580 C CA . ASP A 1 203 ? -43.913 7.812 5.310 1.00 62.75 ? 204 ASP A CA 1 ATOM 1581 C C . ASP A 1 203 ? -42.421 8.156 5.263 1.00 64.34 ? 204 ASP A C 1 ATOM 1582 O O . ASP A 1 203 ? -42.028 9.154 4.636 1.00 64.42 ? 204 ASP A O 1 ATOM 1583 C CB . ASP A 1 203 ? -44.195 6.459 4.605 1.00 64.00 ? 204 ASP A CB 1 ATOM 1584 C CG . ASP A 1 203 ? -43.899 6.471 3.074 1.00 74.59 ? 204 ASP A CG 1 ATOM 1585 O OD1 . ASP A 1 203 ? -43.004 7.213 2.588 1.00 74.32 ? 204 ASP A OD1 1 ATOM 1586 O OD2 . ASP A 1 203 ? -44.567 5.694 2.343 1.00 78.95 ? 204 ASP A OD2 1 ATOM 1587 N N . ALA A 1 204 ? -41.592 7.325 5.895 1.00 58.88 ? 205 ALA A N 1 ATOM 1588 C CA . ALA A 1 204 ? -40.155 7.551 5.846 1.00 57.87 ? 205 ALA A CA 1 ATOM 1589 C C . ALA A 1 204 ? -39.483 7.339 4.456 1.00 58.47 ? 205 ALA A C 1 ATOM 1590 O O . ALA A 1 204 ? -38.381 7.852 4.226 1.00 60.65 ? 205 ALA A O 1 ATOM 1591 C CB . ALA A 1 204 ? -39.437 6.794 6.953 1.00 53.31 ? 205 ALA A CB 1 ATOM 1592 N N . PHE A 1 205 ? -40.126 6.624 3.531 1.00 56.06 ? 206 PHE A N 1 ATOM 1593 C CA . PHE A 1 205 ? -39.584 6.542 2.180 1.00 57.28 ? 206 PHE A CA 1 ATOM 1594 C C . PHE A 1 205 ? -39.594 7.938 1.633 1.00 53.81 ? 206 PHE A C 1 ATOM 1595 O O . PHE A 1 205 ? -38.546 8.465 1.286 1.00 55.27 ? 206 PHE A O 1 ATOM 1596 C CB . PHE A 1 205 ? -40.399 5.668 1.241 1.00 68.04 ? 206 PHE A CB 1 ATOM 1597 C CG . PHE A 1 205 ? -40.449 4.219 1.622 1.00 88.48 ? 206 PHE A CG 1 ATOM 1598 C CD1 . PHE A 1 205 ? -39.491 3.647 2.479 1.00 88.10 ? 206 PHE A CD1 1 ATOM 1599 C CD2 . PHE A 1 205 ? -41.457 3.391 1.072 1.00 104.84 ? 206 PHE A CD2 1 ATOM 1600 C CE1 . PHE A 1 205 ? -39.567 2.298 2.806 1.00 95.76 ? 206 PHE A CE1 1 ATOM 1601 C CE2 . PHE A 1 205 ? -41.528 2.033 1.386 1.00 103.20 ? 206 PHE A CE2 1 ATOM 1602 C CZ . PHE A 1 205 ? -40.581 1.492 2.257 1.00 107.85 ? 206 PHE A CZ 1 ATOM 1603 N N . VAL A 1 206 ? -40.780 8.543 1.603 1.00 51.34 ? 207 VAL A N 1 ATOM 1604 C CA . VAL A 1 206 ? -40.950 9.907 1.094 1.00 50.09 ? 207 VAL A CA 1 ATOM 1605 C C . VAL A 1 206 ? -39.989 10.853 1.804 1.00 50.28 ? 207 VAL A C 1 ATOM 1606 O O . VAL A 1 206 ? -39.287 11.648 1.164 1.00 45.41 ? 207 VAL A O 1 ATOM 1607 C CB . VAL A 1 206 ? -42.400 10.411 1.245 1.00 48.15 ? 207 VAL A CB 1 ATOM 1608 C CG1 . VAL A 1 206 ? -42.481 11.905 0.992 1.00 42.18 ? 207 VAL A CG1 1 ATOM 1609 C CG2 . VAL A 1 206 ? -43.337 9.673 0.298 1.00 48.32 ? 207 VAL A CG2 1 ATOM 1610 N N . CYS A 1 207 ? -39.934 10.723 3.124 1.00 52.73 ? 208 CYS A N 1 ATOM 1611 C CA . CYS A 1 207 ? -39.085 11.562 3.918 1.00 53.70 ? 208 CYS A CA 1 ATOM 1612 C C . CYS A 1 207 ? -37.687 11.515 3.346 1.00 53.94 ? 208 CYS A C 1 ATOM 1613 O O . CYS A 1 207 ? -37.197 12.546 2.896 1.00 64.07 ? 208 CYS A O 1 ATOM 1614 C CB . CYS A 1 207 ? -39.154 11.169 5.385 1.00 59.31 ? 208 CYS A CB 1 ATOM 1615 S SG . CYS A 1 207 ? -38.259 12.254 6.531 1.00 78.93 ? 208 CYS A SG 1 ATOM 1616 N N . GLY A 1 208 ? -37.094 10.323 3.264 1.00 54.25 ? 209 GLY A N 1 ATOM 1617 C CA . GLY A 1 208 ? -35.706 10.155 2.792 1.00 53.61 ? 209 GLY A CA 1 ATOM 1618 C C . GLY A 1 208 ? -35.456 10.460 1.324 1.00 55.77 ? 209 GLY A C 1 ATOM 1619 O O . GLY A 1 208 ? -34.332 10.730 0.925 1.00 57.10 ? 209 GLY A O 1 ATOM 1620 N N . ARG A 1 209 ? -36.500 10.385 0.510 1.00 57.75 ? 210 ARG A N 1 ATOM 1621 C CA . ARG A 1 209 ? -36.426 10.847 -0.868 1.00 58.95 ? 210 ARG A CA 1 ATOM 1622 C C . ARG A 1 209 ? -36.302 12.377 -0.915 1.00 62.87 ? 210 ARG A C 1 ATOM 1623 O O . ARG A 1 209 ? -35.527 12.907 -1.719 1.00 64.74 ? 210 ARG A O 1 ATOM 1624 C CB . ARG A 1 209 ? -37.619 10.345 -1.688 1.00 57.52 ? 210 ARG A CB 1 ATOM 1625 C CG . ARG A 1 209 ? -37.652 8.842 -1.773 1.00 59.05 ? 210 ARG A CG 1 ATOM 1626 C CD . ARG A 1 209 ? -38.131 8.373 -3.124 1.00 73.87 ? 210 ARG A CD 1 ATOM 1627 N NE . ARG A 1 209 ? -39.561 8.068 -3.141 1.00 84.81 ? 210 ARG A NE 1 ATOM 1628 C CZ . ARG A 1 209 ? -40.092 6.921 -2.735 1.00 95.57 ? 210 ARG A CZ 1 ATOM 1629 N NH1 . ARG A 1 209 ? -41.408 6.758 -2.800 1.00 109.35 ? 210 ARG A NH1 1 ATOM 1630 N NH2 . ARG A 1 209 ? -39.317 5.941 -2.261 1.00 91.70 ? 210 ARG A NH2 1 ATOM 1631 N N . ILE A 1 210 ? -37.038 13.077 -0.040 1.00 61.07 ? 211 ILE A N 1 ATOM 1632 C CA . ILE A 1 210 ? -36.929 14.540 0.073 1.00 53.23 ? 211 ILE A CA 1 ATOM 1633 C C . ILE A 1 210 ? -35.566 14.969 0.624 1.00 55.76 ? 211 ILE A C 1 ATOM 1634 O O . ILE A 1 210 ? -35.000 15.945 0.131 1.00 62.30 ? 211 ILE A O 1 ATOM 1635 C CB . ILE A 1 210 ? -38.059 15.166 0.885 1.00 46.82 ? 211 ILE A CB 1 ATOM 1636 C CG1 . ILE A 1 210 ? -39.386 14.899 0.207 1.00 43.97 ? 211 ILE A CG1 1 ATOM 1637 C CG2 . ILE A 1 210 ? -37.888 16.672 0.916 1.00 49.59 ? 211 ILE A CG2 1 ATOM 1638 C CD1 . ILE A 1 210 ? -40.564 15.144 1.109 1.00 40.57 ? 211 ILE A CD1 1 ATOM 1639 N N . CYS A 1 211 ? -35.026 14.234 1.602 1.00 51.53 ? 212 CYS A N 1 ATOM 1640 C CA . CYS A 1 211 ? -33.649 14.460 2.043 1.00 55.26 ? 212 CYS A CA 1 ATOM 1641 C C . CYS A 1 211 ? -32.646 14.344 0.903 1.00 54.90 ? 212 CYS A C 1 ATOM 1642 O O . CYS A 1 211 ? -31.628 15.037 0.867 1.00 54.39 ? 212 CYS A O 1 ATOM 1643 C CB . CYS A 1 211 ? -33.240 13.499 3.155 1.00 60.69 ? 212 CYS A CB 1 ATOM 1644 S SG . CYS A 1 211 ? -31.616 13.933 3.865 1.00 81.71 ? 212 CYS A SG 1 ATOM 1645 N N . THR A 1 212 ? -32.951 13.473 -0.041 1.00 57.89 ? 213 THR A N 1 ATOM 1646 C CA . THR A 1 212 ? -32.051 13.236 -1.135 1.00 63.71 ? 213 THR A CA 1 ATOM 1647 C C . THR A 1 212 ? -31.944 14.424 -2.095 1.00 64.13 ? 213 THR A C 1 ATOM 1648 O O . THR A 1 212 ? -30.831 14.829 -2.407 1.00 73.84 ? 213 THR A O 1 ATOM 1649 C CB . THR A 1 212 ? -32.356 11.917 -1.848 1.00 66.02 ? 213 THR A CB 1 ATOM 1650 O OG1 . THR A 1 212 ? -32.222 10.839 -0.907 1.00 66.03 ? 213 THR A OG1 1 ATOM 1651 C CG2 . THR A 1 212 ? -31.389 11.711 -3.006 1.00 66.74 ? 213 THR A CG2 1 ATOM 1652 N N . HIS A 1 213 ? -33.051 14.992 -2.554 1.00 57.88 ? 214 HIS A N 1 ATOM 1653 C CA . HIS A 1 213 ? -32.902 16.123 -3.464 1.00 59.05 ? 214 HIS A CA 1 ATOM 1654 C C . HIS A 1 213 ? -32.712 17.454 -2.761 1.00 60.04 ? 214 HIS A C 1 ATOM 1655 O O . HIS A 1 213 ? -32.413 18.427 -3.414 1.00 64.05 ? 214 HIS A O 1 ATOM 1656 C CB . HIS A 1 213 ? -34.012 16.203 -4.500 1.00 60.80 ? 214 HIS A CB 1 ATOM 1657 C CG . HIS A 1 213 ? -35.370 16.310 -3.909 1.00 69.54 ? 214 HIS A CG 1 ATOM 1658 N ND1 . HIS A 1 213 ? -35.771 17.396 -3.163 1.00 76.35 ? 214 HIS A ND1 1 ATOM 1659 C CD2 . HIS A 1 213 ? -36.419 15.457 -3.937 1.00 73.73 ? 214 HIS A CD2 1 ATOM 1660 C CE1 . HIS A 1 213 ? -37.010 17.205 -2.751 1.00 80.12 ? 214 HIS A CE1 1 ATOM 1661 N NE2 . HIS A 1 213 ? -37.427 16.037 -3.209 1.00 82.58 ? 214 HIS A NE2 1 ATOM 1662 N N . HIS A 1 214 ? -32.892 17.510 -1.444 1.00 62.93 ? 215 HIS A N 1 ATOM 1663 C CA . HIS A 1 214 ? -32.619 18.737 -0.715 1.00 66.13 ? 215 HIS A CA 1 ATOM 1664 C C . HIS A 1 214 ? -31.124 18.852 -0.548 1.00 71.79 ? 215 HIS A C 1 ATOM 1665 O O . HIS A 1 214 ? -30.505 17.967 0.041 1.00 80.76 ? 215 HIS A O 1 ATOM 1666 C CB . HIS A 1 214 ? -33.279 18.759 0.660 1.00 71.00 ? 215 HIS A CB 1 ATOM 1667 C CG . HIS A 1 214 ? -33.326 20.125 1.283 1.00 76.60 ? 215 HIS A CG 1 ATOM 1668 N ND1 . HIS A 1 214 ? -32.230 20.963 1.340 1.00 77.99 ? 215 HIS A ND1 1 ATOM 1669 C CD2 . HIS A 1 214 ? -34.343 20.799 1.871 1.00 73.46 ? 215 HIS A CD2 1 ATOM 1670 C CE1 . HIS A 1 214 ? -32.573 22.094 1.925 1.00 80.62 ? 215 HIS A CE1 1 ATOM 1671 N NE2 . HIS A 1 214 ? -33.847 22.015 2.269 1.00 79.90 ? 215 HIS A NE2 1 ATOM 1672 N N . PRO A 1 215 ? -30.533 19.945 -1.051 1.00 82.60 ? 216 PRO A N 1 ATOM 1673 C CA . PRO A 1 215 ? -29.072 20.007 -1.099 1.00 87.98 ? 216 PRO A CA 1 ATOM 1674 C C . PRO A 1 215 ? -28.372 20.085 0.254 1.00 82.05 ? 216 PRO A C 1 ATOM 1675 O O . PRO A 1 215 ? -27.331 19.461 0.403 1.00 88.62 ? 216 PRO A O 1 ATOM 1676 C CB . PRO A 1 215 ? -28.805 21.250 -1.952 1.00 94.60 ? 216 PRO A CB 1 ATOM 1677 C CG . PRO A 1 215 ? -30.031 21.358 -2.802 1.00 95.70 ? 216 PRO A CG 1 ATOM 1678 C CD . PRO A 1 215 ? -31.130 21.045 -1.826 1.00 87.46 ? 216 PRO A CD 1 ATOM 1679 N N . GLY A 1 216 ? -28.929 20.812 1.221 1.00 75.33 ? 217 GLY A N 1 ATOM 1680 C CA . GLY A 1 216 ? -28.353 20.863 2.583 1.00 72.90 ? 217 GLY A CA 1 ATOM 1681 C C . GLY A 1 216 ? -28.632 19.689 3.538 1.00 73.92 ? 217 GLY A C 1 ATOM 1682 O O . GLY A 1 216 ? -28.200 19.719 4.696 1.00 80.04 ? 217 GLY A O 1 ATOM 1683 N N . CYS A 1 217 ? -29.335 18.655 3.067 1.00 65.09 ? 218 CYS A N 1 ATOM 1684 C CA . CYS A 1 217 ? -29.761 17.549 3.914 1.00 57.65 ? 218 CYS A CA 1 ATOM 1685 C C . CYS A 1 217 ? -28.812 16.402 3.776 1.00 60.27 ? 218 CYS A C 1 ATOM 1686 O O . CYS A 1 217 ? -28.641 15.875 2.668 1.00 68.31 ? 218 CYS A O 1 ATOM 1687 C CB . CYS A 1 217 ? -31.134 17.054 3.492 1.00 58.10 ? 218 CYS A CB 1 ATOM 1688 S SG . CYS A 1 217 ? -31.815 15.869 4.662 1.00 73.33 ? 218 CYS A SG 1 ATOM 1689 N N . LEU A 1 218 ? -28.217 15.983 4.888 1.00 57.80 ? 219 LEU A N 1 ATOM 1690 C CA . LEU A 1 218 ? -27.343 14.794 4.888 1.00 54.89 ? 219 LEU A CA 1 ATOM 1691 C C . LEU A 1 218 ? -27.948 13.591 5.588 1.00 54.19 ? 219 LEU A C 1 ATOM 1692 O O . LEU A 1 218 ? -27.584 12.448 5.331 1.00 51.53 ? 219 LEU A O 1 ATOM 1693 C CB . LEU A 1 218 ? -26.008 15.114 5.547 1.00 54.83 ? 219 LEU A CB 1 ATOM 1694 C CG . LEU A 1 218 ? -25.140 16.167 4.883 1.00 55.12 ? 219 LEU A CG 1 ATOM 1695 C CD1 . LEU A 1 218 ? -23.880 16.295 5.710 1.00 56.23 ? 219 LEU A CD1 1 ATOM 1696 C CD2 . LEU A 1 218 ? -24.812 15.794 3.446 1.00 55.01 ? 219 LEU A CD2 1 ATOM 1697 N N . PHE A 1 219 ? -28.825 13.862 6.536 1.00 56.79 ? 220 PHE A N 1 ATOM 1698 C CA . PHE A 1 219 ? -29.582 12.818 7.182 1.00 57.87 ? 220 PHE A CA 1 ATOM 1699 C C . PHE A 1 219 ? -30.878 13.392 7.691 1.00 54.85 ? 220 PHE A C 1 ATOM 1700 O O . PHE A 1 219 ? -31.125 14.592 7.551 1.00 45.86 ? 220 PHE A O 1 ATOM 1701 C CB . PHE A 1 219 ? -28.792 12.104 8.282 1.00 64.96 ? 220 PHE A CB 1 ATOM 1702 C CG . PHE A 1 219 ? -27.940 13.004 9.108 1.00 74.03 ? 220 PHE A CG 1 ATOM 1703 C CD1 . PHE A 1 219 ? -26.622 13.271 8.736 1.00 73.15 ? 220 PHE A CD1 1 ATOM 1704 C CD2 . PHE A 1 219 ? -28.441 13.562 10.276 1.00 79.33 ? 220 PHE A CD2 1 ATOM 1705 C CE1 . PHE A 1 219 ? -25.830 14.099 9.502 1.00 76.39 ? 220 PHE A CE1 1 ATOM 1706 C CE2 . PHE A 1 219 ? -27.646 14.391 11.052 1.00 87.28 ? 220 PHE A CE2 1 ATOM 1707 C CZ . PHE A 1 219 ? -26.337 14.659 10.662 1.00 82.48 ? 220 PHE A CZ 1 ATOM 1708 N N . PHE A 1 220 ? -31.715 12.518 8.242 1.00 56.89 ? 221 PHE A N 1 ATOM 1709 C CA . PHE A 1 220 ? -33.068 12.889 8.598 1.00 59.84 ? 221 PHE A CA 1 ATOM 1710 C C . PHE A 1 220 ? -33.643 12.106 9.755 1.00 63.53 ? 221 PHE A C 1 ATOM 1711 O O . PHE A 1 220 ? -33.110 11.066 10.152 1.00 69.77 ? 221 PHE A O 1 ATOM 1712 C CB . PHE A 1 220 ? -33.983 12.780 7.382 1.00 62.56 ? 221 PHE A CB 1 ATOM 1713 C CG . PHE A 1 220 ? -34.282 11.373 6.948 1.00 67.40 ? 221 PHE A CG 1 ATOM 1714 C CD1 . PHE A 1 220 ? -35.450 10.732 7.369 1.00 67.14 ? 221 PHE A CD1 1 ATOM 1715 C CD2 . PHE A 1 220 ? -33.428 10.697 6.069 1.00 70.87 ? 221 PHE A CD2 1 ATOM 1716 C CE1 . PHE A 1 220 ? -35.746 9.436 6.939 1.00 71.08 ? 221 PHE A CE1 1 ATOM 1717 C CE2 . PHE A 1 220 ? -33.723 9.404 5.637 1.00 67.40 ? 221 PHE A CE2 1 ATOM 1718 C CZ . PHE A 1 220 ? -34.878 8.769 6.077 1.00 66.91 ? 221 PHE A CZ 1 ATOM 1719 N N . THR A 1 221 ? -34.736 12.629 10.296 1.00 64.49 ? 222 THR A N 1 ATOM 1720 C CA . THR A 1 221 ? -35.539 11.895 11.243 1.00 58.48 ? 222 THR A CA 1 ATOM 1721 C C . THR A 1 221 ? -36.975 12.097 10.859 1.00 61.60 ? 222 THR A C 1 ATOM 1722 O O . THR A 1 221 ? -37.384 13.193 10.451 1.00 68.07 ? 222 THR A O 1 ATOM 1723 C CB . THR A 1 221 ? -35.306 12.371 12.670 1.00 56.06 ? 222 THR A CB 1 ATOM 1724 O OG1 . THR A 1 221 ? -33.990 11.970 13.105 1.00 53.00 ? 222 THR A OG1 1 ATOM 1725 C CG2 . THR A 1 221 ? -36.366 11.785 13.579 1.00 54.81 ? 222 THR A CG2 1 ATOM 1726 N N . PHE A 1 222 ? -37.723 11.011 10.973 1.00 63.03 ? 223 PHE A N 1 ATOM 1727 C CA . PHE A 1 222 ? -39.143 10.988 10.701 1.00 62.41 ? 223 PHE A CA 1 ATOM 1728 C C . PHE A 1 222 ? -39.875 10.600 11.974 1.00 65.61 ? 223 PHE A C 1 ATOM 1729 O O . PHE A 1 222 ? -39.636 9.525 12.553 1.00 65.94 ? 223 PHE A O 1 ATOM 1730 C CB . PHE A 1 222 ? -39.446 9.981 9.590 1.00 59.76 ? 223 PHE A CB 1 ATOM 1731 C CG . PHE A 1 222 ? -40.873 9.981 9.138 1.00 57.10 ? 223 PHE A CG 1 ATOM 1732 C CD1 . PHE A 1 222 ? -41.388 11.053 8.411 1.00 57.21 ? 223 PHE A CD1 1 ATOM 1733 C CD2 . PHE A 1 222 ? -41.700 8.894 9.417 1.00 55.69 ? 223 PHE A CD2 1 ATOM 1734 C CE1 . PHE A 1 222 ? -42.710 11.053 7.994 1.00 61.51 ? 223 PHE A CE1 1 ATOM 1735 C CE2 . PHE A 1 222 ? -43.018 8.882 9.001 1.00 56.85 ? 223 PHE A CE2 1 ATOM 1736 C CZ . PHE A 1 222 ? -43.526 9.960 8.289 1.00 63.69 ? 223 PHE A CZ 1 ATOM 1737 N N . PHE A 1 223 ? -40.751 11.501 12.405 1.00 60.76 ? 224 PHE A N 1 ATOM 1738 C CA . PHE A 1 223 ? -41.715 11.205 13.441 1.00 59.25 ? 224 PHE A CA 1 ATOM 1739 C C . PHE A 1 223 ? -43.016 10.728 12.809 1.00 59.19 ? 224 PHE A C 1 ATOM 1740 O O . PHE A 1 223 ? -43.810 11.540 12.291 1.00 50.09 ? 224 PHE A O 1 ATOM 1741 C CB . PHE A 1 223 ? -41.907 12.429 14.331 1.00 62.12 ? 224 PHE A CB 1 ATOM 1742 C CG . PHE A 1 223 ? -40.625 12.966 14.866 1.00 64.15 ? 224 PHE A CG 1 ATOM 1743 C CD1 . PHE A 1 223 ? -39.916 12.269 15.840 1.00 67.24 ? 224 PHE A CD1 1 ATOM 1744 C CD2 . PHE A 1 223 ? -40.093 14.145 14.371 1.00 72.47 ? 224 PHE A CD2 1 ATOM 1745 C CE1 . PHE A 1 223 ? -38.709 12.748 16.324 1.00 67.83 ? 224 PHE A CE1 1 ATOM 1746 C CE2 . PHE A 1 223 ? -38.879 14.636 14.848 1.00 67.73 ? 224 PHE A CE2 1 ATOM 1747 C CZ . PHE A 1 223 ? -38.191 13.938 15.829 1.00 68.23 ? 224 PHE A CZ 1 ATOM 1748 N N . SER A 1 224 ? -43.190 9.397 12.841 1.00 64.17 ? 225 SER A N 1 ATOM 1749 C CA . SER A 1 224 ? -44.362 8.663 12.299 1.00 68.22 ? 225 SER A CA 1 ATOM 1750 C C . SER A 1 224 ? -45.663 9.169 12.870 1.00 67.48 ? 225 SER A C 1 ATOM 1751 O O . SER A 1 224 ? -45.647 9.912 13.856 1.00 72.70 ? 225 SER A O 1 ATOM 1752 C CB . SER A 1 224 ? -44.280 7.219 12.731 1.00 74.81 ? 225 SER A CB 1 ATOM 1753 O OG . SER A 1 224 ? -44.624 7.141 14.111 1.00 74.75 ? 225 SER A OG 1 ATOM 1754 N N . GLN A 1 225 ? -46.793 8.738 12.320 1.00 59.93 ? 226 GLN A N 1 ATOM 1755 C CA . GLN A 1 225 ? -48.054 9.245 12.853 1.00 65.22 ? 226 GLN A CA 1 ATOM 1756 C C . GLN A 1 225 ? -48.309 8.776 14.286 1.00 75.49 ? 226 GLN A C 1 ATOM 1757 O O . GLN A 1 225 ? -49.009 9.451 15.048 1.00 79.48 ? 226 GLN A O 1 ATOM 1758 C CB . GLN A 1 225 ? -49.221 8.922 11.954 1.00 62.05 ? 226 GLN A CB 1 ATOM 1759 C CG . GLN A 1 225 ? -49.646 7.476 11.974 1.00 62.01 ? 226 GLN A CG 1 ATOM 1760 C CD . GLN A 1 225 ? -50.513 7.178 10.795 1.00 66.51 ? 226 GLN A CD 1 ATOM 1761 O OE1 . GLN A 1 225 ? -50.022 6.941 9.681 1.00 69.99 ? 226 GLN A OE1 1 ATOM 1762 N NE2 . GLN A 1 225 ? -51.818 7.231 11.012 1.00 68.73 ? 226 GLN A NE2 1 ATOM 1763 N N . GLU A 1 226 ? -47.683 7.652 14.649 1.00 81.20 ? 227 GLU A N 1 ATOM 1764 C CA . GLU A 1 226 ? -47.864 6.990 15.948 1.00 85.48 ? 227 GLU A CA 1 ATOM 1765 C C . GLU A 1 226 ? -47.059 7.622 17.098 1.00 83.07 ? 227 GLU A C 1 ATOM 1766 O O . GLU A 1 226 ? -46.988 7.087 18.210 1.00 95.78 ? 227 GLU A O 1 ATOM 1767 C CB . GLU A 1 226 ? -47.574 5.483 15.816 1.00 91.12 ? 227 GLU A CB 1 ATOM 1768 C CG . GLU A 1 226 ? -48.655 4.692 15.070 1.00 100.46 ? 227 GLU A CG 1 ATOM 1769 C CD . GLU A 1 226 ? -48.330 4.387 13.604 1.00 106.07 ? 227 GLU A CD 1 ATOM 1770 O OE1 . GLU A 1 226 ? -49.214 3.830 12.909 1.00 106.62 ? 227 GLU A OE1 1 ATOM 1771 O OE2 . GLU A 1 226 ? -47.203 4.683 13.136 1.00 106.15 ? 227 GLU A OE2 1 ATOM 1772 N N . TRP A 1 227 ? -46.473 8.774 16.814 1.00 81.32 ? 228 TRP A N 1 ATOM 1773 C CA . TRP A 1 227 ? -45.717 9.573 17.771 1.00 80.14 ? 228 TRP A CA 1 ATOM 1774 C C . TRP A 1 227 ? -46.670 10.234 18.744 1.00 83.58 ? 228 TRP A C 1 ATOM 1775 O O . TRP A 1 227 ? -47.761 10.666 18.325 1.00 83.54 ? 228 TRP A O 1 ATOM 1776 C CB . TRP A 1 227 ? -44.992 10.663 16.993 1.00 74.62 ? 228 TRP A CB 1 ATOM 1777 C CG . TRP A 1 227 ? -44.074 11.571 17.718 1.00 62.32 ? 228 TRP A CG 1 ATOM 1778 C CD1 . TRP A 1 227 ? -44.294 12.879 17.995 1.00 63.57 ? 228 TRP A CD1 1 ATOM 1779 C CD2 . TRP A 1 227 ? -42.748 11.277 18.172 1.00 60.38 ? 228 TRP A CD2 1 ATOM 1780 N NE1 . TRP A 1 227 ? -43.201 13.427 18.625 1.00 65.53 ? 228 TRP A NE1 1 ATOM 1781 C CE2 . TRP A 1 227 ? -42.234 12.465 18.748 1.00 60.50 ? 228 TRP A CE2 1 ATOM 1782 C CE3 . TRP A 1 227 ? -41.944 10.124 18.159 1.00 60.12 ? 228 TRP A CE3 1 ATOM 1783 C CZ2 . TRP A 1 227 ? -40.944 12.543 19.300 1.00 54.11 ? 228 TRP A CZ2 1 ATOM 1784 C CZ3 . TRP A 1 227 ? -40.653 10.197 18.717 1.00 60.23 ? 228 TRP A CZ3 1 ATOM 1785 C CH2 . TRP A 1 227 ? -40.174 11.404 19.282 1.00 57.00 ? 228 TRP A CH2 1 ATOM 1786 N N . PRO A 1 228 ? -46.267 10.300 20.038 1.00 80.07 ? 229 PRO A N 1 ATOM 1787 C CA . PRO A 1 228 ? -46.767 11.140 21.126 1.00 76.45 ? 229 PRO A CA 1 ATOM 1788 C C . PRO A 1 228 ? -47.300 12.520 20.691 1.00 79.87 ? 229 PRO A C 1 ATOM 1789 O O . PRO A 1 228 ? -48.496 12.635 20.422 1.00 83.76 ? 229 PRO A O 1 ATOM 1790 C CB . PRO A 1 228 ? -45.528 11.296 22.026 1.00 78.83 ? 229 PRO A CB 1 ATOM 1791 C CG . PRO A 1 228 ? -44.557 10.233 21.579 1.00 83.91 ? 229 PRO A CG 1 ATOM 1792 C CD . PRO A 1 228 ? -45.262 9.372 20.570 1.00 78.91 ? 229 PRO A CD 1 ATOM 1793 N N . LYS A 1 229 ? -46.437 13.541 20.606 1.00 77.90 ? 230 LYS A N 1 ATOM 1794 C CA . LYS A 1 229 ? -46.888 14.924 20.365 1.00 82.90 ? 230 LYS A CA 1 ATOM 1795 C C . LYS A 1 229 ? -47.702 15.071 19.068 1.00 84.76 ? 230 LYS A C 1 ATOM 1796 O O . LYS A 1 229 ? -47.260 14.681 17.990 1.00 88.10 ? 230 LYS A O 1 ATOM 1797 C CB . LYS A 1 229 ? -45.720 15.923 20.401 1.00 86.40 ? 230 LYS A CB 1 ATOM 1798 C CG . LYS A 1 229 ? -44.878 15.923 21.678 1.00 96.40 ? 230 LYS A CG 1 ATOM 1799 C CD . LYS A 1 229 ? -45.258 17.013 22.684 1.00 106.69 ? 230 LYS A CD 1 ATOM 1800 C CE . LYS A 1 229 ? -44.254 17.028 23.837 1.00 108.73 ? 230 LYS A CE 1 ATOM 1801 N NZ . LYS A 1 229 ? -44.780 17.652 25.085 1.00 107.53 ? 230 LYS A NZ 1 ATOM 1802 N N . GLU A 1 230 ? -48.910 15.604 19.207 1.00 87.17 ? 231 GLU A N 1 ATOM 1803 C CA . GLU A 1 230 ? -49.788 15.922 18.079 1.00 92.50 ? 231 GLU A CA 1 ATOM 1804 C C . GLU A 1 230 ? -49.138 16.809 17.026 1.00 86.42 ? 231 GLU A C 1 ATOM 1805 O O . GLU A 1 230 ? -49.291 16.589 15.826 1.00 82.55 ? 231 GLU A O 1 ATOM 1806 C CB . GLU A 1 230 ? -51.066 16.608 18.579 1.00 108.07 ? 231 GLU A CB 1 ATOM 1807 C CG . GLU A 1 230 ? -52.352 15.853 18.278 1.00 120.72 ? 231 GLU A CG 1 ATOM 1808 C CD . GLU A 1 230 ? -52.554 15.588 16.789 1.00 133.22 ? 231 GLU A CD 1 ATOM 1809 O OE1 . GLU A 1 230 ? -52.325 16.503 15.955 1.00 129.73 ? 231 GLU A OE1 1 ATOM 1810 O OE2 . GLU A 1 230 ? -52.939 14.445 16.453 1.00 138.59 ? 231 GLU A OE2 1 ATOM 1811 N N . SER A 1 231 ? -48.413 17.810 17.505 1.00 85.56 ? 232 SER A N 1 ATOM 1812 C CA . SER A 1 231 ? -47.770 18.804 16.674 1.00 84.00 ? 232 SER A CA 1 ATOM 1813 C C . SER A 1 231 ? -46.629 18.235 15.819 1.00 83.11 ? 232 SER A C 1 ATOM 1814 O O . SER A 1 231 ? -46.036 18.970 15.044 1.00 87.49 ? 232 SER A O 1 ATOM 1815 C CB . SER A 1 231 ? -47.242 19.936 17.568 1.00 88.82 ? 232 SER A CB 1 ATOM 1816 O OG . SER A 1 231 ? -46.503 19.410 18.670 1.00 90.57 ? 232 SER A OG 1 ATOM 1817 N N . GLN A 1 232 ? -46.326 16.940 15.936 1.00 79.69 ? 233 GLN A N 1 ATOM 1818 C CA . GLN A 1 232 ? -45.131 16.375 15.287 1.00 73.49 ? 233 GLN A CA 1 ATOM 1819 C C . GLN A 1 232 ? -45.261 15.108 14.443 1.00 73.30 ? 233 GLN A C 1 ATOM 1820 O O . GLN A 1 232 ? -44.257 14.554 13.995 1.00 82.09 ? 233 GLN A O 1 ATOM 1821 C CB . GLN A 1 232 ? -44.055 16.165 16.321 1.00 69.84 ? 233 GLN A CB 1 ATOM 1822 C CG . GLN A 1 232 ? -43.208 17.387 16.465 1.00 72.12 ? 233 GLN A CG 1 ATOM 1823 C CD . GLN A 1 232 ? -42.651 17.481 17.841 1.00 75.49 ? 233 GLN A CD 1 ATOM 1824 O OE1 . GLN A 1 232 ? -43.401 17.536 18.811 1.00 80.40 ? 233 GLN A OE1 1 ATOM 1825 N NE2 . GLN A 1 232 ? -41.327 17.486 17.946 1.00 78.12 ? 233 GLN A NE2 1 ATOM 1826 N N . ARG A 1 233 ? -46.479 14.649 14.229 1.00 65.39 ? 234 ARG A N 1 ATOM 1827 C CA . ARG A 1 233 ? -46.704 13.525 13.356 1.00 70.16 ? 234 ARG A CA 1 ATOM 1828 C C . ARG A 1 233 ? -46.399 13.879 11.905 1.00 72.11 ? 234 ARG A C 1 ATOM 1829 O O . ARG A 1 233 ? -46.632 15.011 11.473 1.00 68.53 ? 234 ARG A O 1 ATOM 1830 C CB . ARG A 1 233 ? -48.139 13.072 13.486 1.00 78.65 ? 234 ARG A CB 1 ATOM 1831 C CG . ARG A 1 233 ? -48.424 12.451 14.828 1.00 79.67 ? 234 ARG A CG 1 ATOM 1832 C CD . ARG A 1 233 ? -49.629 13.110 15.449 1.00 85.91 ? 234 ARG A CD 1 ATOM 1833 N NE . ARG A 1 233 ? -49.674 12.771 16.863 1.00 95.24 ? 234 ARG A NE 1 ATOM 1834 C CZ . ARG A 1 233 ? -50.580 11.980 17.421 1.00 89.46 ? 234 ARG A CZ 1 ATOM 1835 N NH1 . ARG A 1 233 ? -50.508 11.737 18.715 1.00 85.68 ? 234 ARG A NH1 1 ATOM 1836 N NH2 . ARG A 1 233 ? -51.556 11.443 16.698 1.00 87.18 ? 234 ARG A NH2 1 ATOM 1837 N N . ASN A 1 234 ? -45.848 12.899 11.176 1.00 73.08 ? 235 ASN A N 1 ATOM 1838 C CA . ASN A 1 234 ? -45.506 13.021 9.752 1.00 67.55 ? 235 ASN A CA 1 ATOM 1839 C C . ASN A 1 234 ? -44.482 14.128 9.519 1.00 64.21 ? 235 ASN A C 1 ATOM 1840 O O . ASN A 1 234 ? -44.329 14.663 8.420 1.00 59.09 ? 235 ASN A O 1 ATOM 1841 C CB . ASN A 1 234 ? -46.778 13.244 8.936 1.00 68.23 ? 235 ASN A CB 1 ATOM 1842 C CG . ASN A 1 234 ? -47.859 12.271 9.306 1.00 68.67 ? 235 ASN A CG 1 ATOM 1843 O OD1 . ASN A 1 234 ? -47.719 11.086 9.068 1.00 69.40 ? 235 ASN A OD1 1 ATOM 1844 N ND2 . ASN A 1 234 ? -48.928 12.761 9.932 1.00 74.10 ? 235 ASN A ND2 1 ATOM 1845 N N . LEU A 1 235 ? -43.786 14.471 10.589 1.00 62.82 ? 236 LEU A N 1 ATOM 1846 C CA . LEU A 1 235 ? -42.810 15.506 10.519 1.00 64.18 ? 236 LEU A CA 1 ATOM 1847 C C . LEU A 1 235 ? -41.497 14.908 10.081 1.00 69.58 ? 236 LEU A C 1 ATOM 1848 O O . LEU A 1 235 ? -40.956 14.004 10.740 1.00 78.88 ? 236 LEU A O 1 ATOM 1849 C CB . LEU A 1 235 ? -42.653 16.213 11.856 1.00 60.42 ? 236 LEU A CB 1 ATOM 1850 C CG . LEU A 1 235 ? -41.781 17.450 11.670 1.00 55.48 ? 236 LEU A CG 1 ATOM 1851 C CD1 . LEU A 1 235 ? -42.579 18.606 11.078 1.00 49.34 ? 236 LEU A CD1 1 ATOM 1852 C CD2 . LEU A 1 235 ? -41.122 17.793 12.984 1.00 52.34 ? 236 LEU A CD2 1 ATOM 1853 N N . CYS A 1 236 ? -40.995 15.437 8.965 1.00 68.50 ? 237 CYS A N 1 ATOM 1854 C CA . CYS A 1 236 ? -39.751 15.001 8.350 1.00 59.86 ? 237 CYS A CA 1 ATOM 1855 C C . CYS A 1 236 ? -38.741 16.104 8.596 1.00 56.87 ? 237 CYS A C 1 ATOM 1856 O O . CYS A 1 236 ? -38.771 17.125 7.924 1.00 62.82 ? 237 CYS A O 1 ATOM 1857 C CB . CYS A 1 236 ? -40.008 14.776 6.858 1.00 57.32 ? 237 CYS A CB 1 ATOM 1858 S SG . CYS A 1 236 ? -38.611 14.167 5.904 1.00 69.32 ? 237 CYS A SG 1 ATOM 1859 N N . LEU A 1 237 ? -37.892 15.931 9.598 1.00 54.48 ? 238 LEU A N 1 ATOM 1860 C CA . LEU A 1 237 ? -36.833 16.904 9.879 1.00 58.25 ? 238 LEU A CA 1 ATOM 1861 C C . LEU A 1 237 ? -35.597 16.638 9.037 1.00 63.21 ? 238 LEU A C 1 ATOM 1862 O O . LEU A 1 237 ? -35.031 15.519 9.072 1.00 63.74 ? 238 LEU A O 1 ATOM 1863 C CB . LEU A 1 237 ? -36.382 16.823 11.329 1.00 56.37 ? 238 LEU A CB 1 ATOM 1864 C CG . LEU A 1 237 ? -37.062 17.533 12.470 1.00 54.65 ? 238 LEU A CG 1 ATOM 1865 C CD1 . LEU A 1 237 ? -36.182 17.208 13.661 1.00 50.25 ? 238 LEU A CD1 1 ATOM 1866 C CD2 . LEU A 1 237 ? -37.181 19.032 12.226 1.00 57.79 ? 238 LEU A CD2 1 ATOM 1867 N N . LEU A 1 238 ? -35.148 17.673 8.333 1.00 56.31 ? 239 LEU A N 1 ATOM 1868 C CA . LEU A 1 238 ? -33.993 17.559 7.468 1.00 55.29 ? 239 LEU A CA 1 ATOM 1869 C C . LEU A 1 238 ? -32.763 18.125 8.141 1.00 56.28 ? 239 LEU A C 1 ATOM 1870 O O . LEU A 1 238 ? -32.697 19.316 8.442 1.00 58.35 ? 239 LEU A O 1 ATOM 1871 C CB . LEU A 1 238 ? -34.271 18.255 6.146 1.00 54.35 ? 239 LEU A CB 1 ATOM 1872 C CG . LEU A 1 238 ? -35.563 17.809 5.468 1.00 54.18 ? 239 LEU A CG 1 ATOM 1873 C CD1 . LEU A 1 238 ? -35.902 18.672 4.269 1.00 56.28 ? 239 LEU A CD1 1 ATOM 1874 C CD2 . LEU A 1 238 ? -35.450 16.367 5.031 1.00 58.02 ? 239 LEU A CD2 1 ATOM 1875 N N . LYS A 1 239 ? -31.780 17.259 8.350 1.00 58.63 ? 240 LYS A N 1 ATOM 1876 C CA . LYS A 1 239 ? -30.609 17.576 9.178 1.00 63.80 ? 240 LYS A CA 1 ATOM 1877 C C . LYS A 1 239 ? -29.252 17.686 8.441 1.00 63.60 ? 240 LYS A C 1 ATOM 1878 O O . LYS A 1 239 ? -29.147 17.408 7.234 1.00 68.57 ? 240 LYS A O 1 ATOM 1879 C CB . LYS A 1 239 ? -30.534 16.560 10.326 1.00 66.29 ? 240 LYS A CB 1 ATOM 1880 C CG . LYS A 1 239 ? -31.887 16.318 11.009 1.00 70.48 ? 240 LYS A CG 1 ATOM 1881 C CD . LYS A 1 239 ? -31.837 15.270 12.112 1.00 73.45 ? 240 LYS A CD 1 ATOM 1882 C CE . LYS A 1 239 ? -31.411 15.897 13.424 1.00 83.55 ? 240 LYS A CE 1 ATOM 1883 N NZ . LYS A 1 239 ? -32.597 16.374 14.174 1.00 96.16 ? 240 LYS A NZ 1 ATOM 1884 N N . THR A 1 240 ? -28.233 18.139 9.174 1.00 64.68 ? 241 THR A N 1 ATOM 1885 C CA . THR A 1 240 ? -26.806 18.157 8.723 1.00 70.17 ? 241 THR A CA 1 ATOM 1886 C C . THR A 1 240 ? -25.872 18.329 9.924 1.00 64.84 ? 241 THR A C 1 ATOM 1887 O O . THR A 1 240 ? -26.330 18.643 11.027 1.00 64.98 ? 241 THR A O 1 ATOM 1888 C CB . THR A 1 240 ? -26.468 19.197 7.578 1.00 67.68 ? 241 THR A CB 1 ATOM 1889 O OG1 . THR A 1 240 ? -25.205 18.878 6.960 1.00 57.92 ? 241 THR A OG1 1 ATOM 1890 C CG2 . THR A 1 240 ? -26.423 20.635 8.087 1.00 60.21 ? 241 THR A CG2 1 ATOM 1891 N N . SER A 1 241 ? -24.580 18.104 9.694 1.00 62.92 ? 242 SER A N 1 ATOM 1892 C CA . SER A 1 241 ? -23.554 18.291 10.708 1.00 70.10 ? 242 SER A CA 1 ATOM 1893 C C . SER A 1 241 ? -22.219 18.628 10.068 1.00 73.65 ? 242 SER A C 1 ATOM 1894 O O . SER A 1 241 ? -21.949 18.198 8.949 1.00 74.78 ? 242 SER A O 1 ATOM 1895 C CB . SER A 1 241 ? -23.433 17.039 11.585 1.00 71.33 ? 242 SER A CB 1 ATOM 1896 O OG . SER A 1 241 ? -22.979 15.925 10.842 1.00 68.78 ? 242 SER A OG 1 ATOM 1897 N N . GLU A 1 242 ? -21.397 19.392 10.793 1.00 85.68 ? 243 GLU A N 1 ATOM 1898 C CA . GLU A 1 242 ? -20.025 19.772 10.380 1.00 86.76 ? 243 GLU A CA 1 ATOM 1899 C C . GLU A 1 242 ? -19.187 18.579 9.934 1.00 79.36 ? 243 GLU A C 1 ATOM 1900 O O . GLU A 1 242 ? -18.556 18.620 8.893 1.00 84.41 ? 243 GLU A O 1 ATOM 1901 C CB . GLU A 1 242 ? -19.301 20.489 11.512 1.00 91.37 ? 243 GLU A CB 1 ATOM 1902 C CG . GLU A 1 242 ? -20.192 21.419 12.318 1.00 103.44 ? 243 GLU A CG 1 ATOM 1903 C CD . GLU A 1 242 ? -19.538 22.758 12.573 1.00 110.31 ? 243 GLU A CD 1 ATOM 1904 O OE1 . GLU A 1 242 ? -18.448 22.789 13.189 1.00 114.25 ? 243 GLU A OE1 1 ATOM 1905 O OE2 . GLU A 1 242 ? -20.116 23.779 12.145 1.00 109.24 ? 243 GLU A OE2 1 ATOM 1906 N N . SER A 1 243 ? -19.195 17.521 10.733 1.00 74.38 ? 244 SER A N 1 ATOM 1907 C CA . SER A 1 243 ? -18.615 16.241 10.357 1.00 70.90 ? 244 SER A CA 1 ATOM 1908 C C . SER A 1 243 ? -19.324 15.562 9.186 1.00 76.50 ? 244 SER A C 1 ATOM 1909 O O . SER A 1 243 ? -18.673 14.866 8.405 1.00 82.20 ? 244 SER A O 1 ATOM 1910 C CB . SER A 1 243 ? -18.629 15.311 11.570 1.00 79.35 ? 244 SER A CB 1 ATOM 1911 O OG . SER A 1 243 ? -19.177 14.034 11.265 1.00 84.48 ? 244 SER A OG 1 ATOM 1912 N N . GLY A 1 244 ? -20.649 15.735 9.087 1.00 77.07 ? 245 GLY A N 1 ATOM 1913 C CA . GLY A 1 244 ? -21.470 15.025 8.100 1.00 67.79 ? 245 GLY A CA 1 ATOM 1914 C C . GLY A 1 244 ? -22.195 13.787 8.615 1.00 72.00 ? 245 GLY A C 1 ATOM 1915 O O . GLY A 1 244 ? -23.100 13.292 7.953 1.00 81.48 ? 245 GLY A O 1 ATOM 1916 N N . LEU A 1 245 ? -21.789 13.266 9.773 1.00 75.70 ? 246 LEU A N 1 ATOM 1917 C CA . LEU A 1 245 ? -22.467 12.128 10.410 1.00 76.79 ? 246 LEU A CA 1 ATOM 1918 C C . LEU A 1 245 ? -23.371 12.643 11.493 1.00 76.85 ? 246 LEU A C 1 ATOM 1919 O O . LEU A 1 245 ? -23.147 13.747 11.985 1.00 79.67 ? 246 LEU A O 1 ATOM 1920 C CB . LEU A 1 245 ? -21.466 11.148 11.022 1.00 81.85 ? 246 LEU A CB 1 ATOM 1921 C CG . LEU A 1 245 ? -21.437 9.778 10.348 1.00 87.48 ? 246 LEU A CG 1 ATOM 1922 C CD1 . LEU A 1 245 ? -20.020 9.487 9.842 1.00 79.73 ? 246 LEU A CD1 1 ATOM 1923 C CD2 . LEU A 1 245 ? -21.996 8.684 11.273 1.00 91.62 ? 246 LEU A CD2 1 ATOM 1924 N N . PRO A 1 246 ? -24.407 11.865 11.866 1.00 78.67 ? 247 PRO A N 1 ATOM 1925 C CA . PRO A 1 246 ? -25.066 12.242 13.100 1.00 76.72 ? 247 PRO A CA 1 ATOM 1926 C C . PRO A 1 246 ? -24.135 11.904 14.261 1.00 80.17 ? 247 PRO A C 1 ATOM 1927 O O . PRO A 1 246 ? -23.562 10.792 14.320 1.00 71.37 ? 247 PRO A O 1 ATOM 1928 C CB . PRO A 1 246 ? -26.333 11.388 13.104 1.00 77.87 ? 247 PRO A CB 1 ATOM 1929 C CG . PRO A 1 246 ? -26.008 10.207 12.268 1.00 78.05 ? 247 PRO A CG 1 ATOM 1930 C CD . PRO A 1 246 ? -25.051 10.701 11.225 1.00 82.72 ? 247 PRO A CD 1 ATOM 1931 N N . SER A 1 247 ? -23.939 12.894 15.131 1.00 86.21 ? 248 SER A N 1 ATOM 1932 C CA . SER A 1 247 ? -23.094 12.741 16.312 1.00 88.39 ? 248 SER A CA 1 ATOM 1933 C C . SER A 1 247 ? -23.585 11.528 17.107 1.00 89.27 ? 248 SER A C 1 ATOM 1934 O O . SER A 1 247 ? -22.853 10.560 17.308 1.00 91.96 ? 248 SER A O 1 ATOM 1935 C CB . SER A 1 247 ? -23.126 14.019 17.148 1.00 83.08 ? 248 SER A CB 1 ATOM 1936 O OG . SER A 1 247 ? -24.459 14.451 17.332 1.00 89.47 ? 248 SER A OG 1 ATOM 1937 N N . THR A 1 248 ? -24.862 11.556 17.463 1.00 86.85 ? 249 THR A N 1 ATOM 1938 C CA . THR A 1 248 ? -25.434 10.555 18.327 1.00 88.27 ? 249 THR A CA 1 ATOM 1939 C C . THR A 1 248 ? -26.788 10.031 17.847 1.00 90.59 ? 249 THR A C 1 ATOM 1940 O O . THR A 1 248 ? -27.599 10.796 17.283 1.00 90.65 ? 249 THR A O 1 ATOM 1941 C CB . THR A 1 248 ? -25.611 11.125 19.742 1.00 93.72 ? 249 THR A CB 1 ATOM 1942 O OG1 . THR A 1 248 ? -26.753 10.508 20.350 1.00 109.20 ? 249 THR A OG1 1 ATOM 1943 C CG2 . THR A 1 248 ? -25.816 12.656 19.722 1.00 82.80 ? 249 THR A CG2 1 ATOM 1944 N N . ARG A 1 249 ? -27.026 8.742 18.120 1.00 82.06 ? 250 ARG A N 1 ATOM 1945 C CA . ARG A 1 249 ? -28.333 8.106 17.898 1.00 87.92 ? 250 ARG A CA 1 ATOM 1946 C C . ARG A 1 249 ? -29.142 7.701 19.186 1.00 89.28 ? 250 ARG A C 1 ATOM 1947 O O . ARG A 1 249 ? -28.874 6.660 19.803 1.00 91.83 ? 250 ARG A O 1 ATOM 1948 C CB . ARG A 1 249 ? -28.225 6.971 16.840 1.00 89.54 ? 250 ARG A CB 1 ATOM 1949 C CG . ARG A 1 249 ? -27.586 5.655 17.261 1.00 88.05 ? 250 ARG A CG 1 ATOM 1950 C CD . ARG A 1 249 ? -27.075 4.843 16.070 1.00 92.39 ? 250 ARG A CD 1 ATOM 1951 N NE . ARG A 1 249 ? -26.170 3.775 16.510 1.00 103.53 ? 250 ARG A NE 1 ATOM 1952 C CZ . ARG A 1 249 ? -24.903 3.932 16.931 1.00 111.53 ? 250 ARG A CZ 1 ATOM 1953 N NH1 . ARG A 1 249 ? -24.307 5.128 16.981 1.00 106.48 ? 250 ARG A NH1 1 ATOM 1954 N NH2 . ARG A 1 249 ? -24.209 2.865 17.313 1.00 111.24 ? 250 ARG A NH2 1 ATOM 1955 N N . ILE A 1 250 ? -30.125 8.539 19.558 1.00 79.64 ? 251 ILE A N 1 ATOM 1956 C CA . ILE A 1 250 ? -31.055 8.336 20.708 1.00 75.08 ? 251 ILE A CA 1 ATOM 1957 C C . ILE A 1 250 ? -32.107 7.244 20.421 1.00 76.23 ? 251 ILE A C 1 ATOM 1958 O O . ILE A 1 250 ? -32.505 7.097 19.276 1.00 88.58 ? 251 ILE A O 1 ATOM 1959 C CB . ILE A 1 250 ? -31.786 9.659 21.056 1.00 81.93 ? 251 ILE A CB 1 ATOM 1960 C CG1 . ILE A 1 250 ? -30.804 10.860 21.083 1.00 88.28 ? 251 ILE A CG1 1 ATOM 1961 C CG2 . ILE A 1 250 ? -32.573 9.541 22.362 1.00 91.26 ? 251 ILE A CG2 1 ATOM 1962 C CD1 . ILE A 1 250 ? -31.434 12.253 21.067 1.00 80.04 ? 251 ILE A CD1 1 ATOM 1963 N N . LYS A 1 251 ? -32.567 6.513 21.450 1.00 74.23 ? 252 LYS A N 1 ATOM 1964 C CA . LYS A 1 251 ? -33.420 5.303 21.308 1.00 57.70 ? 252 LYS A CA 1 ATOM 1965 C C . LYS A 1 251 ? -34.631 6.481 21.488 0.00 79.72 ? 252 LYS A C 1 ATOM 1966 O O . LYS A 1 251 ? -34.692 6.968 22.587 0.00 80.42 ? 252 LYS A O 1 ATOM 1967 C CB . LYS A 1 251 ? -33.081 4.564 21.656 0.00 82.93 ? 252 LYS A CB 1 ATOM 1968 C CG . LYS A 1 251 ? -34.133 3.521 21.321 0.00 83.92 ? 252 LYS A CG 1 ATOM 1969 C CD . LYS A 1 251 ? -34.132 2.344 22.280 0.00 86.67 ? 252 LYS A CD 1 ATOM 1970 C CE . LYS A 1 251 ? -33.172 1.257 21.833 0.00 87.55 ? 252 LYS A CE 1 ATOM 1971 N NZ . LYS A 1 251 ? -33.297 0.035 22.679 0.00 89.97 ? 252 LYS A NZ 1 ATOM 1972 N N . LYS A 1 252 ? -35.920 6.563 20.725 1.00 48.57 ? 253 LYS A N 1 ATOM 1973 C CA . LYS A 1 252 ? -36.128 7.674 21.669 1.00 60.35 ? 253 LYS A CA 1 ATOM 1974 C C . LYS A 1 252 ? -38.101 6.058 19.797 0.00 76.45 ? 253 LYS A C 1 ATOM 1975 O O . LYS A 1 252 ? -37.740 5.757 18.684 0.00 77.22 ? 253 LYS A O 1 ATOM 1976 C CB . LYS A 1 252 ? -37.011 8.790 21.045 1.00 62.52 ? 253 LYS A CB 1 ATOM 1977 C CG . LYS A 1 252 ? -37.151 10.034 21.928 1.00 56.41 ? 253 LYS A CG 1 ATOM 1978 C CD . LYS A 1 252 ? -37.339 10.392 22.068 0.00 89.44 ? 253 LYS A CD 1 ATOM 1979 C CE . LYS A 1 252 ? -38.477 10.044 23.010 0.00 92.44 ? 253 LYS A CE 1 ATOM 1980 N NZ . LYS A 1 252 ? -39.284 11.227 23.417 0.00 88.89 ? 253 LYS A NZ 1 ATOM 1981 N N . SER A 1 253 ? -38.379 6.262 19.967 1.00 56.39 ? 254 SER A N 1 ATOM 1982 C CA . SER A 1 253 ? -39.440 5.326 19.647 1.00 71.41 ? 254 SER A CA 1 ATOM 1983 C C . SER A 1 253 ? -40.590 5.940 18.841 1.00 71.80 ? 254 SER A C 1 ATOM 1984 O O . SER A 1 253 ? -41.025 7.065 19.117 1.00 78.10 ? 254 SER A O 1 ATOM 1985 C CB . SER A 1 253 ? -39.995 4.688 20.924 1.00 82.14 ? 254 SER A CB 1 ATOM 1986 O OG . SER A 1 253 ? -40.916 3.646 20.603 1.00 89.53 ? 254 SER A OG 1 ATOM 1987 N N . LYS A 1 254 ? -41.102 5.165 17.883 1.00 67.87 ? 255 LYS A N 1 ATOM 1988 C CA . LYS A 1 254 ? -42.075 5.605 16.864 1.00 68.00 ? 255 LYS A CA 1 ATOM 1989 C C . LYS A 1 254 ? -41.466 6.638 15.890 1.00 72.05 ? 255 LYS A C 1 ATOM 1990 O O . LYS A 1 254 ? -42.179 7.405 15.219 1.00 73.02 ? 255 LYS A O 1 ATOM 1991 C CB . LYS A 1 254 ? -43.428 6.054 17.471 1.00 63.14 ? 255 LYS A CB 1 ATOM 1992 C CG . LYS A 1 254 ? -44.439 4.929 17.704 1.00 62.95 ? 255 LYS A CG 1 ATOM 1993 C CD . LYS A 1 254 ? -44.564 4.561 19.183 1.00 64.47 ? 255 LYS A CD 1 ATOM 1994 C CE . LYS A 1 254 ? -45.943 4.028 19.556 1.00 59.89 ? 255 LYS A CE 1 ATOM 1995 N NZ . LYS A 1 254 ? -45.144 2.601 19.834 0.00 77.72 ? 255 LYS A NZ 1 ATOM 1996 N N . ALA A 1 255 ? -40.137 6.636 15.799 1.00 74.77 ? 256 ALA A N 1 ATOM 1997 C CA . ALA A 1 255 ? -39.428 7.485 14.841 1.00 77.60 ? 256 ALA A CA 1 ATOM 1998 C C . ALA A 1 255 ? -38.363 6.701 14.075 1.00 78.44 ? 256 ALA A C 1 ATOM 1999 O O . ALA A 1 255 ? -37.610 5.932 14.680 1.00 80.89 ? 256 ALA A O 1 ATOM 2000 C CB . ALA A 1 255 ? -38.818 8.689 15.540 1.00 72.46 ? 256 ALA A CB 1 ATOM 2001 N N . LEU A 1 256 ? -38.326 6.887 12.751 1.00 72.75 ? 257 LEU A N 1 ATOM 2002 C CA . LEU A 1 256 ? -37.282 6.296 11.901 1.00 72.30 ? 257 LEU A CA 1 ATOM 2003 C C . LEU A 1 256 ? -36.270 7.376 11.507 1.00 64.63 ? 257 LEU A C 1 ATOM 2004 O O . LEU A 1 256 ? -36.612 8.546 11.413 1.00 63.11 ? 257 LEU A O 1 ATOM 2005 C CB . LEU A 1 256 ? -37.886 5.589 10.665 1.00 68.78 ? 257 LEU A CB 1 ATOM 2006 C CG . LEU A 1 256 ? -38.651 4.619 10.880 0.00 74.55 ? 257 LEU A CG 1 ATOM 2007 C CD1 . LEU A 1 256 ? -40.120 4.956 11.012 0.00 73.34 ? 257 LEU A CD1 1 ATOM 2008 C CD2 . LEU A 1 256 ? -38.418 3.798 9.638 0.00 76.11 ? 257 LEU A CD2 1 ATOM 2009 N N . SER A 1 257 ? -35.022 6.979 11.301 1.00 66.19 ? 258 SER A N 1 ATOM 2010 C CA . SER A 1 257 ? -33.955 7.909 10.894 1.00 68.72 ? 258 SER A CA 1 ATOM 2011 C C . SER A 1 257 ? -33.057 7.339 9.805 1.00 68.85 ? 258 SER A C 1 ATOM 2012 O O . SER A 1 257 ? -32.668 6.173 9.871 1.00 79.20 ? 258 SER A O 1 ATOM 2013 C CB . SER A 1 257 ? -33.101 8.298 12.089 1.00 64.23 ? 258 SER A CB 1 ATOM 2014 O OG . SER A 1 257 ? -33.756 9.304 12.823 1.00 68.58 ? 258 SER A OG 1 ATOM 2015 N N . GLY A 1 258 ? -32.732 8.159 8.806 1.00 63.28 ? 259 GLY A N 1 ATOM 2016 C CA . GLY A 1 258 ? -31.848 7.736 7.718 1.00 62.47 ? 259 GLY A CA 1 ATOM 2017 C C . GLY A 1 258 ? -30.918 8.808 7.165 1.00 61.69 ? 259 GLY A C 1 ATOM 2018 O O . GLY A 1 258 ? -30.732 9.859 7.792 1.00 56.73 ? 259 GLY A O 1 ATOM 2019 N N . PHE A 1 259 ? -30.357 8.527 5.980 1.00 59.69 ? 260 PHE A N 1 ATOM 2020 C CA . PHE A 1 259 ? -29.389 9.397 5.293 1.00 54.05 ? 260 PHE A CA 1 ATOM 2021 C C . PHE A 1 259 ? -29.881 9.795 3.928 1.00 58.17 ? 260 PHE A C 1 ATOM 2022 O O . PHE A 1 259 ? -30.728 9.096 3.339 1.00 62.59 ? 260 PHE A O 1 ATOM 2023 C CB . PHE A 1 259 ? -28.069 8.673 5.105 1.00 48.31 ? 260 PHE A CB 1 ATOM 2024 C CG . PHE A 1 259 ? -27.329 8.461 6.371 1.00 50.26 ? 260 PHE A CG 1 ATOM 2025 C CD1 . PHE A 1 259 ? -27.651 7.381 7.202 1.00 50.02 ? 260 PHE A CD1 1 ATOM 2026 C CD2 . PHE A 1 259 ? -26.322 9.354 6.754 1.00 50.91 ? 260 PHE A CD2 1 ATOM 2027 C CE1 . PHE A 1 259 ? -26.985 7.189 8.389 1.00 51.14 ? 260 PHE A CE1 1 ATOM 2028 C CE2 . PHE A 1 259 ? -25.645 9.171 7.942 1.00 52.11 ? 260 PHE A CE2 1 ATOM 2029 C CZ . PHE A 1 259 ? -25.979 8.087 8.758 1.00 56.55 ? 260 PHE A CZ 1 ATOM 2030 N N . SER A 1 260 ? -29.338 10.915 3.431 1.00 58.85 ? 261 SER A N 1 ATOM 2031 C CA . SER A 1 260 ? -29.491 11.343 2.047 1.00 58.23 ? 261 SER A CA 1 ATOM 2032 C C . SER A 1 260 ? -28.989 10.233 1.149 1.00 61.33 ? 261 SER A C 1 ATOM 2033 O O . SER A 1 260 ? -28.366 9.281 1.623 1.00 60.09 ? 261 SER A O 1 ATOM 2034 C CB . SER A 1 260 ? -28.675 12.596 1.796 1.00 61.35 ? 261 SER A CB 1 ATOM 2035 O OG . SER A 1 260 ? -28.863 13.067 0.475 1.00 68.93 ? 261 SER A OG 1 ATOM 2036 N N . LEU A 1 261 ? -29.298 10.328 -0.141 1.00 67.77 ? 262 LEU A N 1 ATOM 2037 C CA . LEU A 1 261 ? -28.683 9.439 -1.134 1.00 65.97 ? 262 LEU A CA 1 ATOM 2038 C C . LEU A 1 261 ? -28.267 10.175 -2.431 1.00 65.92 ? 262 LEU A C 1 ATOM 2039 O O . LEU A 1 261 ? -28.262 9.566 -3.513 1.00 61.97 ? 262 LEU A O 1 ATOM 2040 C CB . LEU A 1 261 ? -29.584 8.231 -1.414 1.00 59.01 ? 262 LEU A CB 1 ATOM 2041 C CG . LEU A 1 261 ? -30.071 7.299 -0.289 1.00 58.68 ? 262 LEU A CG 1 ATOM 2042 C CD1 . LEU A 1 261 ? -31.327 6.603 -0.796 1.00 56.20 ? 262 LEU A CD1 1 ATOM 2043 C CD2 . LEU A 1 261 ? -29.050 6.277 0.227 1.00 52.34 ? 262 LEU A CD2 1 ATOM 2044 N N . GLN A 1 262 ? -27.890 11.463 -2.314 1.00 62.64 ? 263 GLN A N 1 ATOM 2045 C CA . GLN A 1 262 ? -27.565 12.304 -3.484 1.00 67.09 ? 263 GLN A CA 1 ATOM 2046 C C . GLN A 1 262 ? -26.565 11.589 -4.388 1.00 72.01 ? 263 GLN A C 1 ATOM 2047 O O . GLN A 1 262 ? -26.507 11.827 -5.601 1.00 74.53 ? 263 GLN A O 1 ATOM 2048 C CB . GLN A 1 262 ? -27.040 13.700 -3.086 1.00 59.17 ? 263 GLN A CB 1 ATOM 2049 C CG . GLN A 1 262 ? -26.099 13.291 -2.009 0.00 77.50 ? 263 GLN A CG 1 ATOM 2050 C CD . GLN A 1 262 ? -24.964 12.492 -0.594 1.00 113.11 ? 263 GLN A CD 1 ATOM 2051 O OE1 . GLN A 1 262 ? -24.736 13.688 -0.816 1.00 106.79 ? 263 GLN A OE1 1 ATOM 2052 N NE2 . GLN A 1 262 ? -24.821 11.950 0.619 1.00 105.64 ? 263 GLN A NE2 1 ATOM 2053 N N . SER A 1 263 ? -25.812 10.684 -3.766 1.00 73.66 ? 264 SER A N 1 ATOM 2054 C CA . SER A 1 263 ? -24.763 9.922 -4.411 1.00 67.45 ? 264 SER A CA 1 ATOM 2055 C C . SER A 1 263 ? -25.254 8.794 -5.311 1.00 65.24 ? 264 SER A C 1 ATOM 2056 O O . SER A 1 263 ? -24.734 8.625 -6.393 1.00 73.52 ? 264 SER A O 1 ATOM 2057 C CB . SER A 1 263 ? -23.822 9.382 -3.363 1.00 63.06 ? 264 SER A CB 1 ATOM 2058 O OG . SER A 1 263 ? -22.656 8.968 -4.002 1.00 67.75 ? 264 SER A OG 1 ATOM 2059 N N . CYS A 1 264 ? -26.256 8.038 -4.877 1.00 67.25 ? 265 CYS A N 1 ATOM 2060 C CA . CYS A 1 264 ? -26.813 6.953 -5.680 1.00 67.35 ? 265 CYS A CA 1 ATOM 2061 C C . CYS A 1 264 ? -28.041 7.409 -6.388 1.00 64.65 ? 265 CYS A C 1 ATOM 2062 O O . CYS A 1 264 ? -28.941 6.609 -6.591 1.00 66.88 ? 265 CYS A O 1 ATOM 2063 C CB . CYS A 1 264 ? -27.168 5.761 -4.809 1.00 74.33 ? 265 CYS A CB 1 ATOM 2064 S SG . CYS A 1 264 ? -25.687 5.022 -4.115 1.00 108.74 ? 265 CYS A SG 1 ATOM 2065 N N . ARG A 1 265 ? -28.046 8.678 -6.794 1.00 71.10 ? 266 ARG A N 1 ATOM 2066 C CA . ARG A 1 265 ? -29.250 9.428 -7.196 1.00 78.43 ? 266 ARG A CA 1 ATOM 2067 C C . ARG A 1 265 ? -30.047 8.781 -8.343 1.00 78.23 ? 266 ARG A C 1 ATOM 2068 O O . ARG A 1 265 ? -31.251 8.549 -8.221 1.00 83.33 ? 266 ARG A O 1 ATOM 2069 C CB . ARG A 1 265 ? -28.893 10.889 -7.511 1.00 78.47 ? 266 ARG A CB 1 ATOM 2070 C CG . ARG A 1 265 ? -30.005 11.868 -7.222 1.00 87.71 ? 266 ARG A CG 1 ATOM 2071 C CD . ARG A 1 265 ? -29.621 13.290 -7.598 1.00 105.22 ? 266 ARG A CD 1 ATOM 2072 N NE . ARG A 1 265 ? -30.771 14.192 -7.461 1.00 113.38 ? 266 ARG A NE 1 ATOM 2073 C CZ . ARG A 1 265 ? -30.928 15.347 -8.107 1.00 111.26 ? 266 ARG A CZ 1 ATOM 2074 N NH1 . ARG A 1 265 ? -32.016 16.072 -7.892 1.00 106.10 ? 266 ARG A NH1 1 ATOM 2075 N NH2 . ARG A 1 265 ? -30.014 15.781 -8.970 1.00 108.07 ? 266 ARG A NH2 1 ATOM 2076 N N . HIS A 1 266 ? -29.371 8.484 -9.445 1.00 71.95 ? 267 HIS A N 1 ATOM 2077 C CA . HIS A 1 266 ? -29.963 7.731 -10.553 1.00 75.89 ? 267 HIS A CA 1 ATOM 2078 C C . HIS A 1 266 ? -29.932 6.323 -10.030 1.00 80.01 ? 267 HIS A C 1 ATOM 2079 O O . HIS A 1 266 ? -29.169 6.074 -9.112 1.00 100.45 ? 267 HIS A O 1 ATOM 2080 C CB . HIS A 1 266 ? -29.083 7.925 -11.779 1.00 83.72 ? 267 HIS A CB 1 ATOM 2081 C CG . HIS A 1 266 ? -28.648 9.352 -11.964 1.00 101.17 ? 267 HIS A CG 1 ATOM 2082 N ND1 . HIS A 1 266 ? -27.724 9.961 -11.136 1.00 103.89 ? 267 HIS A ND1 1 ATOM 2083 C CD2 . HIS A 1 266 ? -29.061 10.308 -12.833 1.00 103.27 ? 267 HIS A CD2 1 ATOM 2084 C CE1 . HIS A 1 266 ? -27.568 11.220 -11.505 1.00 106.48 ? 267 HIS A CE1 1 ATOM 2085 N NE2 . HIS A 1 266 ? -28.367 11.456 -12.533 1.00 109.61 ? 267 HIS A NE2 1 ATOM 2086 N N . SER A 1 267 ? -30.759 5.407 -10.533 1.00 76.13 ? 268 SER A N 1 ATOM 2087 C CA . SER A 1 267 ? -30.835 4.009 -9.974 1.00 71.97 ? 268 SER A CA 1 ATOM 2088 C C . SER A 1 267 ? -31.748 3.849 -8.742 1.00 66.51 ? 268 SER A C 1 ATOM 2089 O O . SER A 1 267 ? -32.043 2.726 -8.292 1.00 66.21 ? 268 SER A O 1 ATOM 2090 C CB . SER A 1 267 ? -29.444 3.424 -9.646 1.00 72.77 ? 268 SER A CB 1 ATOM 2091 O OG . SER A 1 267 ? -29.016 3.843 -8.349 1.00 63.34 ? 268 SER A OG 1 ATOM 2092 N N . ILE A 1 268 ? -32.145 4.979 -8.178 1.00 65.14 ? 269 ILE A N 1 ATOM 2093 C CA . ILE A 1 268 ? -33.151 5.031 -7.128 1.00 67.61 ? 269 ILE A CA 1 ATOM 2094 C C . ILE A 1 268 ? -34.218 6.041 -7.572 1.00 68.04 ? 269 ILE A C 1 ATOM 2095 O O . ILE A 1 268 ? -33.869 7.068 -8.175 1.00 67.95 ? 269 ILE A O 1 ATOM 2096 C CB . ILE A 1 268 ? -32.552 5.407 -5.729 1.00 68.61 ? 269 ILE A CB 1 ATOM 2097 C CG1 . ILE A 1 268 ? -31.897 6.788 -5.751 1.00 67.35 ? 269 ILE A CG1 1 ATOM 2098 C CG2 . ILE A 1 268 ? -31.572 4.344 -5.208 1.00 62.02 ? 269 ILE A CG2 1 ATOM 2099 C CD1 . ILE A 1 268 ? -31.716 7.413 -4.389 1.00 76.45 ? 269 ILE A CD1 1 ATOM 2100 N N . PRO A 1 269 ? -35.518 5.761 -7.302 1.00 71.63 ? 270 PRO A N 1 ATOM 2101 C CA . PRO A 1 269 ? -36.493 6.833 -7.584 1.00 75.45 ? 270 PRO A CA 1 ATOM 2102 C C . PRO A 1 269 ? -36.321 7.983 -6.576 1.00 81.04 ? 270 PRO A C 1 ATOM 2103 O O . PRO A 1 269 ? -35.896 7.747 -5.433 1.00 84.76 ? 270 PRO A O 1 ATOM 2104 C CB . PRO A 1 269 ? -37.846 6.137 -7.436 1.00 63.44 ? 270 PRO A CB 1 ATOM 2105 C CG . PRO A 1 269 ? -37.576 5.073 -6.423 1.00 66.78 ? 270 PRO A CG 1 ATOM 2106 C CD . PRO A 1 269 ? -36.164 4.595 -6.662 1.00 67.22 ? 270 PRO A CD 1 ATOM 2107 N N . VAL A 1 270 ? -36.573 9.215 -7.011 1.00 79.96 ? 271 VAL A N 1 ATOM 2108 C CA . VAL A 1 270 ? -36.430 10.373 -6.122 1.00 76.11 ? 271 VAL A CA 1 ATOM 2109 C C . VAL A 1 270 ? -37.660 11.257 -6.225 1.00 74.92 ? 271 VAL A C 1 ATOM 2110 O O . VAL A 1 270 ? -38.272 11.584 -5.219 1.00 80.94 ? 271 VAL A O 1 ATOM 2111 C CB . VAL A 1 270 ? -35.139 11.187 -6.379 1.00 68.06 ? 271 VAL A CB 1 ATOM 2112 C CG1 . VAL A 1 270 ? -35.102 12.429 -5.501 1.00 67.73 ? 271 VAL A CG1 1 ATOM 2113 C CG2 . VAL A 1 270 ? -33.908 10.353 -6.099 1.00 69.18 ? 271 VAL A CG2 1 ATOM 2114 N N . PHE A 1 271 ? -38.015 11.627 -7.442 1.00 73.42 ? 272 PHE A N 1 ATOM 2115 C CA . PHE A 1 271 ? -39.096 12.553 -7.658 1.00 78.25 ? 272 PHE A CA 1 ATOM 2116 C C . PHE A 1 271 ? -40.387 11.809 -7.874 1.00 82.20 ? 272 PHE A C 1 ATOM 2117 O O . PHE A 1 271 ? -41.452 12.414 -7.928 1.00 102.92 ? 272 PHE A O 1 ATOM 2118 C CB . PHE A 1 271 ? -38.758 13.509 -8.806 1.00 77.61 ? 272 PHE A CB 1 ATOM 2119 C CG . PHE A 1 271 ? -37.584 14.392 -8.500 1.00 85.52 ? 272 PHE A CG 1 ATOM 2120 C CD1 . PHE A 1 271 ? -36.277 13.964 -8.759 1.00 89.96 ? 272 PHE A CD1 1 ATOM 2121 C CD2 . PHE A 1 271 ? -37.770 15.635 -7.896 1.00 89.90 ? 272 PHE A CD2 1 ATOM 2122 C CE1 . PHE A 1 271 ? -35.181 14.767 -8.434 1.00 92.26 ? 272 PHE A CE1 1 ATOM 2123 C CE2 . PHE A 1 271 ? -36.676 16.444 -7.569 1.00 94.86 ? 272 PHE A CE2 1 ATOM 2124 C CZ . PHE A 1 271 ? -35.381 16.008 -7.840 1.00 90.41 ? 272 PHE A CZ 1 ATOM 2125 N N . CYS A 1 272 ? -40.311 10.489 -7.933 1.00 74.74 ? 273 CYS A N 1 ATOM 2126 C CA . CYS A 1 272 ? -41.466 9.750 -8.358 1.00 74.73 ? 273 CYS A CA 1 ATOM 2127 C C . CYS A 1 272 ? -42.064 8.951 -7.215 1.00 80.33 ? 273 CYS A C 1 ATOM 2128 O O . CYS A 1 272 ? -41.505 7.947 -6.798 1.00 95.69 ? 273 CYS A O 1 ATOM 2129 C CB . CYS A 1 272 ? -41.117 8.910 -9.562 1.00 73.03 ? 273 CYS A CB 1 ATOM 2130 S SG . CYS A 1 272 ? -42.551 8.156 -10.304 1.00 94.65 ? 273 CYS A SG 1 ATOM 2131 N N . HIS A 1 273 ? -43.179 9.447 -6.675 1.00 85.44 ? 274 HIS A N 1 ATOM 2132 C CA . HIS A 1 273 ? -43.914 8.756 -5.615 1.00 87.05 ? 274 HIS A CA 1 ATOM 2133 C C . HIS A 1 273 ? -45.284 8.343 -6.181 1.00 91.68 ? 274 HIS A C 1 ATOM 2134 O O . HIS A 1 273 ? -46.284 9.071 -6.086 1.00 103.59 ? 274 HIS A O 1 ATOM 2135 C CB . HIS A 1 273 ? -44.058 9.588 -4.324 1.00 92.24 ? 274 HIS A CB 1 ATOM 2136 C CG . HIS A 1 273 ? -42.964 10.597 -4.079 1.00 96.82 ? 274 HIS A CG 1 ATOM 2137 N ND1 . HIS A 1 273 ? -41.963 10.403 -3.149 1.00 95.17 ? 274 HIS A ND1 1 ATOM 2138 C CD2 . HIS A 1 273 ? -42.762 11.840 -4.587 1.00 99.91 ? 274 HIS A CD2 1 ATOM 2139 C CE1 . HIS A 1 273 ? -41.175 11.467 -3.120 1.00 90.13 ? 274 HIS A CE1 1 ATOM 2140 N NE2 . HIS A 1 273 ? -41.637 12.353 -3.984 1.00 88.81 ? 274 HIS A NE2 1 ATOM 2141 N N . SER A 1 274 ? -45.293 7.159 -6.786 1.00 90.00 ? 275 SER A N 1 ATOM 2142 C CA . SER A 1 274 ? -46.428 6.595 -7.515 1.00 74.73 ? 275 SER A CA 1 ATOM 2143 C C . SER A 1 274 ? -47.464 5.952 -6.583 1.00 64.57 ? 275 SER A C 1 ATOM 2144 O O . SER A 1 274 ? -48.583 5.641 -7.001 1.00 54.16 ? 275 SER A O 1 ATOM 2145 C CB . SER A 1 274 ? -45.892 5.529 -8.456 1.00 80.12 ? 275 SER A CB 1 ATOM 2146 O OG . SER A 1 274 ? -45.199 4.539 -7.699 1.00 87.11 ? 275 SER A OG 1 ATOM 2147 N N . SER A 1 275 ? -47.061 5.740 -5.333 1.00 58.73 ? 276 SER A N 1 ATOM 2148 C CA . SER A 1 275 ? -47.914 5.174 -4.299 1.00 60.36 ? 276 SER A CA 1 ATOM 2149 C C . SER A 1 275 ? -49.116 6.078 -3.883 1.00 59.72 ? 276 SER A C 1 ATOM 2150 O O . SER A 1 275 ? -49.073 7.314 -4.070 1.00 62.11 ? 276 SER A O 1 ATOM 2151 C CB . SER A 1 275 ? -47.043 4.802 -3.106 1.00 62.09 ? 276 SER A CB 1 ATOM 2152 O OG . SER A 1 275 ? -47.738 3.954 -2.217 1.00 77.81 ? 276 SER A OG 1 ATOM 2153 N N . PHE A 1 276 ? -50.187 5.444 -3.368 1.00 56.96 ? 277 PHE A N 1 ATOM 2154 C CA . PHE A 1 276 ? -51.439 6.121 -2.937 1.00 54.97 ? 277 PHE A CA 1 ATOM 2155 C C . PHE A 1 276 ? -51.614 5.915 -1.454 1.00 58.16 ? 277 PHE A C 1 ATOM 2156 O O . PHE A 1 276 ? -51.200 4.883 -0.914 1.00 65.60 ? 277 PHE A O 1 ATOM 2157 C CB . PHE A 1 276 ? -52.688 5.576 -3.612 1.00 49.75 ? 277 PHE A CB 1 ATOM 2158 C CG . PHE A 1 276 ? -52.739 5.780 -5.098 1.00 53.44 ? 277 PHE A CG 1 ATOM 2159 C CD1 . PHE A 1 276 ? -52.087 4.904 -5.971 1.00 53.68 ? 277 PHE A CD1 1 ATOM 2160 C CD2 . PHE A 1 276 ? -53.493 6.812 -5.638 1.00 58.64 ? 277 PHE A CD2 1 ATOM 2161 C CE1 . PHE A 1 276 ? -52.158 5.087 -7.347 1.00 57.64 ? 277 PHE A CE1 1 ATOM 2162 C CE2 . PHE A 1 276 ? -53.570 7.000 -7.021 1.00 61.45 ? 277 PHE A CE2 1 ATOM 2163 C CZ . PHE A 1 276 ? -52.902 6.137 -7.874 1.00 58.85 ? 277 PHE A CZ 1 ATOM 2164 N N . TYR A 1 277 ? -52.223 6.896 -0.798 1.00 55.31 ? 278 TYR A N 1 ATOM 2165 C CA . TYR A 1 277 ? -52.268 6.901 0.645 1.00 55.62 ? 278 TYR A CA 1 ATOM 2166 C C . TYR A 1 277 ? -53.708 6.988 1.071 1.00 65.29 ? 278 TYR A C 1 ATOM 2167 O O . TYR A 1 277 ? -54.397 7.973 0.762 1.00 71.80 ? 278 TYR A O 1 ATOM 2168 C CB . TYR A 1 277 ? -51.413 8.023 1.213 1.00 50.11 ? 278 TYR A CB 1 ATOM 2169 C CG . TYR A 1 277 ? -49.955 7.879 0.883 1.00 44.32 ? 278 TYR A CG 1 ATOM 2170 C CD1 . TYR A 1 277 ? -49.097 7.119 1.710 1.00 42.38 ? 278 TYR A CD1 1 ATOM 2171 C CD2 . TYR A 1 277 ? -49.416 8.502 -0.274 1.00 45.72 ? 278 TYR A CD2 1 ATOM 2172 C CE1 . TYR A 1 277 ? -47.731 6.987 1.408 1.00 43.68 ? 278 TYR A CE1 1 ATOM 2173 C CE2 . TYR A 1 277 ? -48.063 8.359 -0.615 1.00 46.56 ? 278 TYR A CE2 1 ATOM 2174 C CZ . TYR A 1 277 ? -47.226 7.610 0.227 1.00 47.32 ? 278 TYR A CZ 1 ATOM 2175 O OH . TYR A 1 277 ? -45.905 7.502 -0.109 1.00 49.59 ? 278 TYR A OH 1 ATOM 2176 N N . HIS A 1 278 ? -54.152 5.921 1.747 1.00 68.77 ? 279 HIS A N 1 ATOM 2177 C CA . HIS A 1 278 ? -55.578 5.607 1.914 1.00 68.47 ? 279 HIS A CA 1 ATOM 2178 C C . HIS A 1 278 ? -56.052 6.013 3.278 1.00 67.65 ? 279 HIS A C 1 ATOM 2179 O O . HIS A 1 278 ? -55.331 5.818 4.249 1.00 68.25 ? 279 HIS A O 1 ATOM 2180 C CB . HIS A 1 278 ? -55.830 4.118 1.666 1.00 68.67 ? 279 HIS A CB 1 ATOM 2181 C CG . HIS A 1 278 ? -55.780 3.742 0.218 1.00 70.88 ? 279 HIS A CG 1 ATOM 2182 N ND1 . HIS A 1 278 ? -56.813 4.015 -0.656 1.00 69.69 ? 279 HIS A ND1 1 ATOM 2183 C CD2 . HIS A 1 278 ? -54.806 3.156 -0.522 1.00 71.79 ? 279 HIS A CD2 1 ATOM 2184 C CE1 . HIS A 1 278 ? -56.488 3.595 -1.868 1.00 69.56 ? 279 HIS A CE1 1 ATOM 2185 N NE2 . HIS A 1 278 ? -55.276 3.068 -1.813 1.00 73.91 ? 279 HIS A NE2 1 ATOM 2186 N N . ASP A 1 279 ? -57.261 6.582 3.346 1.00 71.30 ? 280 ASP A N 1 ATOM 2187 C CA . ASP A 1 279 ? -57.735 7.292 4.544 1.00 73.39 ? 280 ASP A CA 1 ATOM 2188 C C . ASP A 1 279 ? -56.651 8.298 4.998 1.00 67.95 ? 280 ASP A C 1 ATOM 2189 O O . ASP A 1 279 ? -56.159 8.270 6.146 1.00 58.01 ? 280 ASP A O 1 ATOM 2190 C CB . ASP A 1 279 ? -58.120 6.288 5.638 1.00 80.37 ? 280 ASP A CB 1 ATOM 2191 C CG . ASP A 1 279 ? -58.928 6.907 6.758 1.00 92.82 ? 280 ASP A CG 1 ATOM 2192 O OD1 . ASP A 1 279 ? -59.955 7.578 6.498 1.00 98.01 ? 280 ASP A OD1 1 ATOM 2193 O OD2 . ASP A 1 279 ? -58.537 6.684 7.923 1.00 101.57 ? 280 ASP A OD2 1 ATOM 2194 N N . THR A 1 280 ? -56.261 9.145 4.040 1.00 63.95 ? 281 THR A N 1 ATOM 2195 C CA . THR A 1 280 ? -55.186 10.119 4.208 1.00 65.86 ? 281 THR A CA 1 ATOM 2196 C C . THR A 1 280 ? -55.542 11.367 3.421 1.00 67.76 ? 281 THR A C 1 ATOM 2197 O O . THR A 1 280 ? -55.891 11.292 2.237 1.00 67.58 ? 281 THR A O 1 ATOM 2198 C CB . THR A 1 280 ? -53.825 9.573 3.731 1.00 66.04 ? 281 THR A CB 1 ATOM 2199 O OG1 . THR A 1 280 ? -53.370 8.541 4.617 1.00 68.06 ? 281 THR A OG1 1 ATOM 2200 C CG2 . THR A 1 280 ? -52.791 10.676 3.701 1.00 66.41 ? 281 THR A CG2 1 ATOM 2201 N N . ASP A 1 281 ? -55.464 12.520 4.080 1.00 69.99 ? 282 ASP A N 1 ATOM 2202 C CA . ASP A 1 281 ? -55.744 13.780 3.394 1.00 67.21 ? 282 ASP A CA 1 ATOM 2203 C C . ASP A 1 281 ? -54.558 14.709 3.488 1.00 60.22 ? 282 ASP A C 1 ATOM 2204 O O . ASP A 1 281 ? -54.001 14.969 4.579 1.00 55.73 ? 282 ASP A O 1 ATOM 2205 C CB . ASP A 1 281 ? -57.046 14.406 3.892 1.00 74.66 ? 282 ASP A CB 1 ATOM 2206 C CG . ASP A 1 281 ? -58.235 13.434 3.774 1.00 87.67 ? 282 ASP A CG 1 ATOM 2207 O OD1 . ASP A 1 281 ? -58.349 12.526 4.661 1.00 84.96 ? 282 ASP A OD1 1 ATOM 2208 O OD2 . ASP A 1 281 ? -59.023 13.568 2.789 1.00 78.24 ? 282 ASP A OD2 1 ATOM 2209 N N . PHE A 1 282 ? -54.141 15.143 2.307 1.00 51.70 ? 283 PHE A N 1 ATOM 2210 C CA . PHE A 1 282 ? -53.022 16.050 2.171 1.00 52.91 ? 283 PHE A CA 1 ATOM 2211 C C . PHE A 1 282 ? -53.532 17.487 2.152 1.00 53.79 ? 283 PHE A C 1 ATOM 2212 O O . PHE A 1 282 ? -54.274 17.876 1.239 1.00 59.87 ? 283 PHE A O 1 ATOM 2213 C CB . PHE A 1 282 ? -52.245 15.770 0.878 1.00 51.56 ? 283 PHE A CB 1 ATOM 2214 C CG . PHE A 1 282 ? -51.355 14.548 0.923 1.00 52.01 ? 283 PHE A CG 1 ATOM 2215 C CD1 . PHE A 1 282 ? -51.203 13.777 2.089 1.00 51.13 ? 283 PHE A CD1 1 ATOM 2216 C CD2 . PHE A 1 282 ? -50.633 14.187 -0.217 1.00 50.96 ? 283 PHE A CD2 1 ATOM 2217 C CE1 . PHE A 1 282 ? -50.368 12.669 2.104 1.00 52.11 ? 283 PHE A CE1 1 ATOM 2218 C CE2 . PHE A 1 282 ? -49.796 13.075 -0.205 1.00 53.63 ? 283 PHE A CE2 1 ATOM 2219 C CZ . PHE A 1 282 ? -49.659 12.317 0.960 1.00 54.62 ? 283 PHE A CZ 1 ATOM 2220 N N . LEU A 1 283 ? -53.128 18.277 3.139 1.00 47.34 ? 284 LEU A N 1 ATOM 2221 C CA . LEU A 1 283 ? -53.549 19.653 3.188 1.00 44.63 ? 284 LEU A CA 1 ATOM 2222 C C . LEU A 1 283 ? -52.686 20.572 2.310 1.00 44.07 ? 284 LEU A C 1 ATOM 2223 O O . LEU A 1 283 ? -51.460 20.435 2.284 1.00 42.94 ? 284 LEU A O 1 ATOM 2224 C CB . LEU A 1 283 ? -53.657 20.118 4.646 1.00 45.53 ? 284 LEU A CB 1 ATOM 2225 C CG . LEU A 1 283 ? -54.830 19.500 5.456 1.00 50.26 ? 284 LEU A CG 1 ATOM 2226 C CD1 . LEU A 1 283 ? -55.159 20.380 6.640 1.00 50.53 ? 284 LEU A CD1 1 ATOM 2227 C CD2 . LEU A 1 283 ? -56.131 19.249 4.685 1.00 46.24 ? 284 LEU A CD2 1 ATOM 2228 N N . GLY A 1 284 ? -53.347 21.470 1.568 1.00 40.80 ? 285 GLY A N 1 ATOM 2229 C CA . GLY A 1 284 ? -52.675 22.518 0.803 1.00 42.48 ? 285 GLY A CA 1 ATOM 2230 C C . GLY A 1 284 ? -53.646 23.435 0.074 1.00 45.68 ? 285 GLY A C 1 ATOM 2231 O O . GLY A 1 284 ? -54.841 23.348 0.297 1.00 50.05 ? 285 GLY A O 1 ATOM 2232 N N . GLU A 1 285 ? -53.136 24.322 -0.786 1.00 45.11 ? 286 GLU A N 1 ATOM 2233 C CA . GLU A 1 285 ? -53.959 25.305 -1.489 1.00 49.97 ? 286 GLU A CA 1 ATOM 2234 C C . GLU A 1 285 ? -54.648 24.643 -2.659 1.00 50.73 ? 286 GLU A C 1 ATOM 2235 O O . GLU A 1 285 ? -53.997 24.012 -3.497 1.00 53.78 ? 286 GLU A O 1 ATOM 2236 C CB . GLU A 1 285 ? -53.132 26.484 -1.989 1.00 53.27 ? 286 GLU A CB 1 ATOM 2237 C CG . GLU A 1 285 ? -52.262 27.132 -0.917 1.00 82.54 ? 286 GLU A CG 1 ATOM 2238 C CD . GLU A 1 285 ? -51.092 27.959 -1.465 1.00 85.35 ? 286 GLU A CD 1 ATOM 2239 O OE1 . GLU A 1 285 ? -50.157 28.234 -0.660 1.00 86.82 ? 286 GLU A OE1 1 ATOM 2240 O OE2 . GLU A 1 285 ? -51.099 28.335 -2.673 1.00 77.73 ? 286 GLU A OE2 1 ATOM 2241 N N . GLU A 1 286 ? -55.965 24.785 -2.710 1.00 48.48 ? 287 GLU A N 1 ATOM 2242 C CA . GLU A 1 286 ? -56.759 24.101 -3.717 1.00 50.12 ? 287 GLU A CA 1 ATOM 2243 C C . GLU A 1 286 ? -56.730 24.837 -5.033 1.00 50.14 ? 287 GLU A C 1 ATOM 2244 O O . GLU A 1 286 ? -56.768 26.074 -5.091 1.00 54.87 ? 287 GLU A O 1 ATOM 2245 C CB . GLU A 1 286 ? -58.205 23.949 -3.275 1.00 53.18 ? 287 GLU A CB 1 ATOM 2246 C CG . GLU A 1 286 ? -58.408 23.102 -2.036 1.00 53.53 ? 287 GLU A CG 1 ATOM 2247 C CD . GLU A 1 286 ? -59.700 23.451 -1.318 1.00 59.49 ? 287 GLU A CD 1 ATOM 2248 O OE1 . GLU A 1 286 ? -60.423 24.386 -1.777 1.00 59.62 ? 287 GLU A OE1 1 ATOM 2249 O OE2 . GLU A 1 286 ? -59.983 22.796 -0.288 1.00 47.44 ? 287 GLU A OE2 1 ATOM 2250 N N . LEU A 1 287 ? -56.721 24.052 -6.090 1.00 49.71 ? 288 LEU A N 1 ATOM 2251 C CA . LEU A 1 287 ? -56.401 24.533 -7.400 1.00 51.10 ? 288 LEU A CA 1 ATOM 2252 C C . LEU A 1 287 ? -57.541 24.238 -8.342 1.00 52.51 ? 288 LEU A C 1 ATOM 2253 O O . LEU A 1 287 ? -57.910 25.092 -9.117 1.00 52.82 ? 288 LEU A O 1 ATOM 2254 C CB . LEU A 1 287 ? -55.113 23.859 -7.849 1.00 55.65 ? 288 LEU A CB 1 ATOM 2255 C CG . LEU A 1 287 ? -54.547 24.156 -9.219 1.00 60.23 ? 288 LEU A CG 1 ATOM 2256 C CD1 . LEU A 1 287 ? -53.851 25.512 -9.220 1.00 60.53 ? 288 LEU A CD1 1 ATOM 2257 C CD2 . LEU A 1 287 ? -53.595 23.021 -9.561 1.00 61.39 ? 288 LEU A CD2 1 ATOM 2258 N N . ASP A 1 288 ? -58.065 23.014 -8.299 1.00 58.24 ? 289 ASP A N 1 ATOM 2259 C CA . ASP A 1 288 ? -59.388 22.702 -8.852 1.00 55.08 ? 289 ASP A CA 1 ATOM 2260 C C . ASP A 1 288 ? -60.049 21.577 -8.061 1.00 50.55 ? 289 ASP A C 1 ATOM 2261 O O . ASP A 1 288 ? -59.415 20.939 -7.203 1.00 49.24 ? 289 ASP A O 1 ATOM 2262 C CB . ASP A 1 288 ? -59.300 22.347 -10.340 1.00 64.46 ? 289 ASP A CB 1 ATOM 2263 C CG . ASP A 1 288 ? -60.621 22.582 -11.090 1.00 75.22 ? 289 ASP A CG 1 ATOM 2264 O OD1 . ASP A 1 288 ? -61.687 22.704 -10.444 1.00 78.86 ? 289 ASP A OD1 1 ATOM 2265 O OD2 . ASP A 1 288 ? -60.602 22.640 -12.343 1.00 78.57 ? 289 ASP A OD2 1 ATOM 2266 N N . ILE A 1 289 ? -61.339 21.389 -8.302 1.00 48.96 ? 290 ILE A N 1 ATOM 2267 C CA . ILE A 1 289 ? -62.059 20.206 -7.831 1.00 56.15 ? 290 ILE A CA 1 ATOM 2268 C C . ILE A 1 289 ? -62.887 19.695 -8.964 1.00 61.77 ? 290 ILE A C 1 ATOM 2269 O O . ILE A 1 289 ? -63.696 20.437 -9.542 1.00 67.97 ? 290 ILE A O 1 ATOM 2270 C CB . ILE A 1 289 ? -63.042 20.423 -6.654 1.00 53.51 ? 290 ILE A CB 1 ATOM 2271 C CG1 . ILE A 1 289 ? -62.702 21.656 -5.812 1.00 51.87 ? 290 ILE A CG1 1 ATOM 2272 C CG2 . ILE A 1 289 ? -63.124 19.139 -5.828 1.00 57.57 ? 290 ILE A CG2 1 ATOM 2273 C CD1 . ILE A 1 289 ? -62.932 21.473 -4.331 1.00 52.37 ? 290 ILE A CD1 1 ATOM 2274 N N . VAL A 1 290 ? -62.705 18.417 -9.261 1.00 63.27 ? 291 VAL A N 1 ATOM 2275 C CA . VAL A 1 290 ? -63.300 17.822 -10.458 1.00 62.24 ? 291 VAL A CA 1 ATOM 2276 C C . VAL A 1 290 ? -63.880 16.422 -10.185 1.00 62.11 ? 291 VAL A C 1 ATOM 2277 O O . VAL A 1 290 ? -63.394 15.700 -9.300 1.00 56.97 ? 291 VAL A O 1 ATOM 2278 C CB . VAL A 1 290 ? -62.283 17.814 -11.631 1.00 57.63 ? 291 VAL A CB 1 ATOM 2279 C CG1 . VAL A 1 290 ? -61.992 19.225 -12.086 1.00 52.56 ? 291 VAL A CG1 1 ATOM 2280 C CG2 . VAL A 1 290 ? -60.976 17.179 -11.206 1.00 64.74 ? 291 VAL A CG2 1 ATOM 2281 N N . ALA A 1 291 ? -64.940 16.084 -10.931 1.00 65.59 ? 292 ALA A N 1 ATOM 2282 C CA . ALA A 1 291 ? -65.544 14.728 -10.983 1.00 63.67 ? 292 ALA A CA 1 ATOM 2283 C C . ALA A 1 291 ? -64.532 13.688 -11.456 1.00 62.35 ? 292 ALA A C 1 ATOM 2284 O O . ALA A 1 291 ? -63.764 13.937 -12.405 1.00 59.01 ? 292 ALA A O 1 ATOM 2285 C CB . ALA A 1 291 ? -66.738 14.726 -11.928 1.00 58.16 ? 292 ALA A CB 1 ATOM 2286 N N . ALA A 1 292 ? -64.521 12.530 -10.808 1.00 55.67 ? 293 ALA A N 1 ATOM 2287 C CA . ALA A 1 292 ? -63.520 11.532 -11.145 1.00 63.33 ? 293 ALA A CA 1 ATOM 2288 C C . ALA A 1 292 ? -63.981 10.172 -10.695 1.00 70.77 ? 293 ALA A C 1 ATOM 2289 O O . ALA A 1 292 ? -64.435 10.012 -9.550 1.00 69.41 ? 293 ALA A O 1 ATOM 2290 C CB . ALA A 1 292 ? -62.148 11.880 -10.538 1.00 64.12 ? 293 ALA A CB 1 ATOM 2291 N N . LYS A 1 293 ? -63.843 9.201 -11.603 1.00 75.23 ? 294 LYS A N 1 ATOM 2292 C CA . LYS A 1 293 ? -64.371 7.860 -11.402 1.00 75.05 ? 294 LYS A CA 1 ATOM 2293 C C . LYS A 1 293 ? -63.473 6.997 -10.545 1.00 78.37 ? 294 LYS A C 1 ATOM 2294 O O . LYS A 1 293 ? -63.967 6.160 -9.790 1.00 83.42 ? 294 LYS A O 1 ATOM 2295 C CB . LYS A 1 293 ? -64.683 7.206 -12.739 1.00 77.65 ? 294 LYS A CB 1 ATOM 2296 C CG . LYS A 1 293 ? -65.976 7.742 -13.343 1.00 85.61 ? 294 LYS A CG 1 ATOM 2297 C CD . LYS A 1 293 ? -66.081 7.507 -14.843 1.00 93.42 ? 294 LYS A CD 1 ATOM 2298 C CE . LYS A 1 293 ? -66.991 8.556 -15.468 1.00 108.52 ? 294 LYS A CE 1 ATOM 2299 N NZ . LYS A 1 293 ? -67.786 8.028 -16.614 1.00 115.58 ? 294 LYS A NZ 1 ATOM 2300 N N . SER A 1 294 ? -62.163 7.218 -10.650 1.00 79.98 ? 295 SER A N 1 ATOM 2301 C CA . SER A 1 294 ? -61.173 6.517 -9.827 1.00 78.87 ? 295 SER A CA 1 ATOM 2302 C C . SER A 1 294 ? -60.177 7.514 -9.283 1.00 78.37 ? 295 SER A C 1 ATOM 2303 O O . SER A 1 294 ? -59.976 8.569 -9.884 1.00 76.22 ? 295 SER A O 1 ATOM 2304 C CB . SER A 1 294 ? -60.413 5.504 -10.672 1.00 81.41 ? 295 SER A CB 1 ATOM 2305 O OG . SER A 1 294 ? -59.735 6.168 -11.735 1.00 81.28 ? 295 SER A OG 1 ATOM 2306 N N . HIS A 1 295 ? -59.527 7.151 -8.173 1.00 76.53 ? 296 HIS A N 1 ATOM 2307 C CA . HIS A 1 295 ? -58.378 7.894 -7.651 1.00 72.17 ? 296 HIS A CA 1 ATOM 2308 C C . HIS A 1 295 ? -57.138 7.832 -8.554 1.00 67.46 ? 296 HIS A C 1 ATOM 2309 O O . HIS A 1 295 ? -56.192 8.587 -8.378 1.00 67.33 ? 296 HIS A O 1 ATOM 2310 C CB . HIS A 1 295 ? -58.032 7.406 -6.260 1.00 72.99 ? 296 HIS A CB 1 ATOM 2311 C CG . HIS A 1 295 ? -57.632 5.974 -6.207 1.00 78.94 ? 296 HIS A CG 1 ATOM 2312 N ND1 . HIS A 1 295 ? -58.478 4.989 -5.752 1.00 87.01 ? 296 HIS A ND1 1 ATOM 2313 C CD2 . HIS A 1 295 ? -56.473 5.359 -6.538 1.00 80.78 ? 296 HIS A CD2 1 ATOM 2314 C CE1 . HIS A 1 295 ? -57.855 3.825 -5.805 1.00 93.73 ? 296 HIS A CE1 1 ATOM 2315 N NE2 . HIS A 1 295 ? -56.636 4.022 -6.276 1.00 86.66 ? 296 HIS A NE2 1 ATOM 2316 N N . GLU A 1 296 ? -57.145 6.894 -9.489 1.00 68.24 ? 297 GLU A N 1 ATOM 2317 C CA . GLU A 1 296 ? -56.157 6.819 -10.533 1.00 65.86 ? 297 GLU A CA 1 ATOM 2318 C C . GLU A 1 296 ? -56.427 7.962 -11.464 1.00 67.14 ? 297 GLU A C 1 ATOM 2319 O O . GLU A 1 296 ? -55.505 8.674 -11.834 1.00 77.12 ? 297 GLU A O 1 ATOM 2320 C CB . GLU A 1 296 ? -56.263 5.503 -11.305 1.00 71.91 ? 297 GLU A CB 1 ATOM 2321 C CG . GLU A 1 296 ? -55.678 4.280 -10.611 1.00 82.60 ? 297 GLU A CG 1 ATOM 2322 C CD . GLU A 1 296 ? -56.624 3.602 -9.631 1.00 94.82 ? 297 GLU A CD 1 ATOM 2323 O OE1 . GLU A 1 296 ? -56.114 2.925 -8.708 1.00 102.37 ? 297 GLU A OE1 1 ATOM 2324 O OE2 . GLU A 1 296 ? -57.867 3.723 -9.777 1.00 105.39 ? 297 GLU A OE2 1 ATOM 2325 N N . ALA A 1 297 ? -57.694 8.154 -11.837 1.00 70.99 ? 298 ALA A N 1 ATOM 2326 C CA . ALA A 1 297 ? -58.063 9.199 -12.809 1.00 72.34 ? 298 ALA A CA 1 ATOM 2327 C C . ALA A 1 297 ? -57.820 10.559 -12.208 1.00 73.05 ? 298 ALA A C 1 ATOM 2328 O O . ALA A 1 297 ? -57.733 11.547 -12.939 1.00 71.34 ? 298 ALA A O 1 ATOM 2329 C CB . ALA A 1 297 ? -59.512 9.067 -13.232 1.00 79.77 ? 298 ALA A CB 1 ATOM 2330 N N . CYS A 1 298 ? -57.718 10.574 -10.870 1.00 72.06 ? 299 CYS A N 1 ATOM 2331 C CA . CYS A 1 298 ? -57.381 11.746 -10.080 1.00 67.99 ? 299 CYS A CA 1 ATOM 2332 C C . CYS A 1 298 ? -55.911 12.084 -10.308 1.00 63.32 ? 299 CYS A C 1 ATOM 2333 O O . CYS A 1 298 ? -55.592 13.190 -10.778 1.00 66.66 ? 299 CYS A O 1 ATOM 2334 C CB . CYS A 1 298 ? -57.708 11.524 -8.592 1.00 69.77 ? 299 CYS A CB 1 ATOM 2335 S SG . CYS A 1 298 ? -57.862 13.022 -7.563 1.00 90.47 ? 299 CYS A SG 1 ATOM 2336 N N . GLN A 1 299 ? -55.028 11.131 -10.018 1.00 55.17 ? 300 GLN A N 1 ATOM 2337 C CA . GLN A 1 299 ? -53.614 11.277 -10.328 1.00 57.07 ? 300 GLN A CA 1 ATOM 2338 C C . GLN A 1 299 ? -53.402 11.810 -11.759 1.00 58.85 ? 300 GLN A C 1 ATOM 2339 O O . GLN A 1 299 ? -52.670 12.789 -11.951 1.00 60.13 ? 300 GLN A O 1 ATOM 2340 C CB . GLN A 1 299 ? -52.860 9.966 -10.103 1.00 58.53 ? 300 GLN A CB 1 ATOM 2341 C CG . GLN A 1 299 ? -51.341 10.078 -10.105 1.00 65.22 ? 300 GLN A CG 1 ATOM 2342 C CD . GLN A 1 299 ? -50.691 8.951 -9.309 1.00 77.59 ? 300 GLN A CD 1 ATOM 2343 O OE1 . GLN A 1 299 ? -50.801 7.779 -9.681 1.00 82.50 ? 300 GLN A OE1 1 ATOM 2344 N NE2 . GLN A 1 299 ? -50.014 9.298 -8.198 1.00 77.14 ? 300 GLN A NE2 1 ATOM 2345 N N . LYS A 1 300 ? -54.071 11.206 -12.744 1.00 59.30 ? 301 LYS A N 1 ATOM 2346 C CA . LYS A 1 300 ? -53.802 11.516 -14.154 1.00 62.65 ? 301 LYS A CA 1 ATOM 2347 C C . LYS A 1 300 ? -54.201 12.951 -14.442 1.00 63.98 ? 301 LYS A C 1 ATOM 2348 O O . LYS A 1 300 ? -53.567 13.618 -15.256 1.00 65.82 ? 301 LYS A O 1 ATOM 2349 C CB . LYS A 1 300 ? -54.462 10.500 -15.106 1.00 69.33 ? 301 LYS A CB 1 ATOM 2350 C CG . LYS A 1 300 ? -54.342 10.803 -16.603 1.00 78.75 ? 301 LYS A CG 1 ATOM 2351 C CD . LYS A 1 300 ? -53.837 9.613 -17.416 1.00 99.17 ? 301 LYS A CD 1 ATOM 2352 C CE . LYS A 1 300 ? -52.333 9.723 -17.712 1.00 107.14 ? 301 LYS A CE 1 ATOM 2353 N NZ . LYS A 1 300 ? -51.758 8.495 -18.344 1.00 103.68 ? 301 LYS A NZ 1 ATOM 2354 N N . LEU A 1 301 ? -55.225 13.427 -13.735 1.00 64.39 ? 302 LEU A N 1 ATOM 2355 C CA . LEU A 1 301 ? -55.614 14.832 -13.790 1.00 62.98 ? 302 LEU A CA 1 ATOM 2356 C C . LEU A 1 301 ? -54.639 15.739 -13.073 1.00 63.49 ? 302 LEU A C 1 ATOM 2357 O O . LEU A 1 301 ? -54.369 16.814 -13.609 1.00 66.71 ? 302 LEU A O 1 ATOM 2358 C CB . LEU A 1 301 ? -57.020 15.057 -13.245 1.00 62.85 ? 302 LEU A CB 1 ATOM 2359 C CG . LEU A 1 301 ? -58.149 14.716 -14.202 1.00 55.82 ? 302 LEU A CG 1 ATOM 2360 C CD1 . LEU A 1 301 ? -59.420 14.797 -13.397 1.00 47.68 ? 302 LEU A CD1 1 ATOM 2361 C CD2 . LEU A 1 301 ? -58.154 15.662 -15.400 1.00 56.15 ? 302 LEU A CD2 1 ATOM 2362 N N . CYS A 1 302 ? -54.120 15.328 -11.896 1.00 57.02 ? 303 CYS A N 1 ATOM 2363 C CA . CYS A 1 302 ? -53.025 16.083 -11.229 1.00 62.95 ? 303 CYS A CA 1 ATOM 2364 C C . CYS A 1 302 ? -51.800 16.193 -12.117 1.00 66.79 ? 303 CYS A C 1 ATOM 2365 O O . CYS A 1 302 ? -51.332 17.306 -12.394 1.00 71.17 ? 303 CYS A O 1 ATOM 2366 C CB . CYS A 1 302 ? -52.613 15.512 -9.857 1.00 66.14 ? 303 CYS A CB 1 ATOM 2367 S SG . CYS A 1 302 ? -51.470 16.589 -8.908 1.00 78.04 ? 303 CYS A SG 1 ATOM 2368 N N . THR A 1 303 ? -51.312 15.031 -12.572 1.00 66.01 ? 304 THR A N 1 ATOM 2369 C CA . THR A 1 303 ? -50.158 14.926 -13.462 1.00 55.84 ? 304 THR A CA 1 ATOM 2370 C C . THR A 1 303 ? -50.304 15.791 -14.690 1.00 54.07 ? 304 THR A C 1 ATOM 2371 O O . THR A 1 303 ? -49.321 16.346 -15.161 1.00 57.91 ? 304 THR A O 1 ATOM 2372 C CB . THR A 1 303 ? -49.900 13.479 -13.856 1.00 54.09 ? 304 THR A CB 1 ATOM 2373 O OG1 . THR A 1 303 ? -49.488 12.759 -12.697 1.00 57.55 ? 304 THR A OG1 1 ATOM 2374 C CG2 . THR A 1 303 ? -48.801 13.391 -14.847 1.00 56.06 ? 304 THR A CG2 1 ATOM 2375 N N . ASN A 1 304 ? -51.535 15.934 -15.170 1.00 55.99 ? 305 ASN A N 1 ATOM 2376 C CA . ASN A 1 304 ? -51.823 16.654 -16.415 1.00 58.05 ? 305 ASN A CA 1 ATOM 2377 C C . ASN A 1 304 ? -52.005 18.116 -16.246 1.00 53.84 ? 305 ASN A C 1 ATOM 2378 O O . ASN A 1 304 ? -52.130 18.818 -17.239 1.00 50.74 ? 305 ASN A O 1 ATOM 2379 C CB . ASN A 1 304 ? -53.076 16.119 -17.081 1.00 62.84 ? 305 ASN A CB 1 ATOM 2380 C CG . ASN A 1 304 ? -52.773 15.053 -18.090 1.00 70.11 ? 305 ASN A CG 1 ATOM 2381 O OD1 . ASN A 1 304 ? -52.023 14.112 -17.818 1.00 76.49 ? 305 ASN A OD1 1 ATOM 2382 N ND2 . ASN A 1 304 ? -53.358 15.188 -19.276 1.00 81.85 ? 305 ASN A ND2 1 ATOM 2383 N N . ALA A 1 305 ? -52.068 18.556 -14.989 1.00 54.86 ? 306 ALA A N 1 ATOM 2384 C CA . ALA A 1 305 ? -52.220 19.970 -14.643 1.00 53.67 ? 306 ALA A CA 1 ATOM 2385 C C . ALA A 1 305 ? -50.894 20.400 -14.058 1.00 57.70 ? 306 ALA A C 1 ATOM 2386 O O . ALA A 1 305 ? -50.422 19.863 -13.006 1.00 59.05 ? 306 ALA A O 1 ATOM 2387 C CB . ALA A 1 305 ? -53.349 20.159 -13.651 1.00 51.91 ? 306 ALA A CB 1 ATOM 2388 N N . VAL A 1 306 ? -50.251 21.329 -14.762 1.00 56.89 ? 307 VAL A N 1 ATOM 2389 C CA . VAL A 1 306 ? -48.831 21.536 -14.474 1.00 58.96 ? 307 VAL A CA 1 ATOM 2390 C C . VAL A 1 306 ? -48.586 22.085 -13.058 1.00 57.98 ? 307 VAL A C 1 ATOM 2391 O O . VAL A 1 306 ? -47.567 21.727 -12.430 1.00 55.83 ? 307 VAL A O 1 ATOM 2392 C CB . VAL A 1 306 ? -48.072 22.302 -15.576 1.00 55.92 ? 307 VAL A CB 1 ATOM 2393 C CG1 . VAL A 1 306 ? -48.420 23.784 -15.574 1.00 56.32 ? 307 VAL A CG1 1 ATOM 2394 C CG2 . VAL A 1 306 ? -46.570 22.094 -15.421 1.00 48.80 ? 307 VAL A CG2 1 ATOM 2395 N N . ARG A 1 307 ? -49.539 22.893 -12.560 1.00 51.06 ? 308 ARG A N 1 ATOM 2396 C CA . ARG A 1 307 ? -49.377 23.549 -11.264 1.00 47.13 ? 308 ARG A CA 1 ATOM 2397 C C . ARG A 1 307 ? -49.598 22.648 -10.079 1.00 49.71 ? 308 ARG A C 1 ATOM 2398 O O . ARG A 1 307 ? -48.980 22.877 -9.026 1.00 52.65 ? 308 ARG A O 1 ATOM 2399 C CB . ARG A 1 307 ? -50.160 24.843 -11.173 1.00 43.07 ? 308 ARG A CB 1 ATOM 2400 C CG . ARG A 1 307 ? -49.498 25.848 -12.089 1.00 48.02 ? 308 ARG A CG 1 ATOM 2401 C CD . ARG A 1 307 ? -50.117 27.231 -12.120 1.00 47.72 ? 308 ARG A CD 1 ATOM 2402 N NE . ARG A 1 307 ? -49.770 27.961 -10.921 1.00 47.27 ? 308 ARG A NE 1 ATOM 2403 C CZ . ARG A 1 307 ? -50.658 28.407 -10.063 1.00 47.42 ? 308 ARG A CZ 1 ATOM 2404 N NH1 . ARG A 1 307 ? -51.944 28.223 -10.320 1.00 57.85 ? 308 ARG A NH1 1 ATOM 2405 N NH2 . ARG A 1 307 ? -50.260 29.057 -8.976 1.00 44.73 ? 308 ARG A NH2 1 ATOM 2406 N N . CYS A 1 308 ? -50.405 21.595 -10.292 1.00 47.46 ? 309 CYS A N 1 ATOM 2407 C CA . CYS A 1 308 ? -50.753 20.601 -9.286 1.00 46.58 ? 309 CYS A CA 1 ATOM 2408 C C . CYS A 1 308 ? -49.505 19.856 -8.873 1.00 43.78 ? 309 CYS A C 1 ATOM 2409 O O . CYS A 1 308 ? -48.722 19.424 -9.732 1.00 46.60 ? 309 CYS A O 1 ATOM 2410 C CB . CYS A 1 308 ? -51.801 19.614 -9.831 1.00 52.88 ? 309 CYS A CB 1 ATOM 2411 S SG . CYS A 1 308 ? -52.411 18.442 -8.586 1.00 65.81 ? 309 CYS A SG 1 ATOM 2412 N N . GLN A 1 309 ? -49.334 19.719 -7.564 1.00 40.39 ? 310 GLN A N 1 ATOM 2413 C CA . GLN A 1 309 ? -48.196 19.024 -6.979 1.00 44.22 ? 310 GLN A CA 1 ATOM 2414 C C . GLN A 1 309 ? -48.658 17.773 -6.258 1.00 48.06 ? 310 GLN A C 1 ATOM 2415 O O . GLN A 1 309 ? -47.887 16.844 -6.068 1.00 58.26 ? 310 GLN A O 1 ATOM 2416 C CB . GLN A 1 309 ? -47.460 19.900 -5.952 1.00 44.14 ? 310 GLN A CB 1 ATOM 2417 C CG . GLN A 1 309 ? -47.227 21.359 -6.338 1.00 46.26 ? 310 GLN A CG 1 ATOM 2418 C CD . GLN A 1 309 ? -46.634 22.207 -5.219 1.00 47.18 ? 310 GLN A CD 1 ATOM 2419 O OE1 . GLN A 1 309 ? -46.608 21.805 -4.052 1.00 49.74 ? 310 GLN A OE1 1 ATOM 2420 N NE2 . GLN A 1 309 ? -46.138 23.389 -5.580 1.00 48.08 ? 310 GLN A NE2 1 ATOM 2421 N N . PHE A 1 310 ? -49.897 17.777 -5.799 1.00 46.60 ? 311 PHE A N 1 ATOM 2422 C CA . PHE A 1 310 ? -50.479 16.643 -5.094 1.00 49.79 ? 311 PHE A CA 1 ATOM 2423 C C . PHE A 1 310 ? -51.996 16.802 -5.072 1.00 53.15 ? 311 PHE A C 1 ATOM 2424 O O . PHE A 1 310 ? -52.530 17.878 -5.417 1.00 51.60 ? 311 PHE A O 1 ATOM 2425 C CB . PHE A 1 310 ? -49.904 16.453 -3.674 1.00 50.31 ? 311 PHE A CB 1 ATOM 2426 C CG . PHE A 1 310 ? -49.866 17.709 -2.837 1.00 57.06 ? 311 PHE A CG 1 ATOM 2427 C CD1 . PHE A 1 310 ? -50.977 18.124 -2.100 1.00 57.99 ? 311 PHE A CD1 1 ATOM 2428 C CD2 . PHE A 1 310 ? -48.709 18.473 -2.759 1.00 58.33 ? 311 PHE A CD2 1 ATOM 2429 C CE1 . PHE A 1 310 ? -50.932 19.279 -1.321 1.00 55.35 ? 311 PHE A CE1 1 ATOM 2430 C CE2 . PHE A 1 310 ? -48.666 19.634 -1.978 1.00 59.23 ? 311 PHE A CE2 1 ATOM 2431 C CZ . PHE A 1 310 ? -49.776 20.035 -1.260 1.00 55.68 ? 311 PHE A CZ 1 ATOM 2432 N N . PHE A 1 311 ? -52.683 15.729 -4.668 1.00 51.48 ? 312 PHE A N 1 ATOM 2433 C CA . PHE A 1 311 ? -54.142 15.661 -4.735 1.00 49.38 ? 312 PHE A CA 1 ATOM 2434 C C . PHE A 1 311 ? -54.693 14.846 -3.570 1.00 48.27 ? 312 PHE A C 1 ATOM 2435 O O . PHE A 1 311 ? -53.970 14.030 -2.942 1.00 45.24 ? 312 PHE A O 1 ATOM 2436 C CB . PHE A 1 311 ? -54.567 14.998 -6.049 1.00 51.50 ? 312 PHE A CB 1 ATOM 2437 C CG . PHE A 1 311 ? -54.190 13.560 -6.103 1.00 57.89 ? 312 PHE A CG 1 ATOM 2438 C CD1 . PHE A 1 311 ? -55.070 12.578 -5.647 1.00 58.42 ? 312 PHE A CD1 1 ATOM 2439 C CD2 . PHE A 1 311 ? -52.914 13.185 -6.511 1.00 60.57 ? 312 PHE A CD2 1 ATOM 2440 C CE1 . PHE A 1 311 ? -54.688 11.250 -5.638 1.00 61.38 ? 312 PHE A CE1 1 ATOM 2441 C CE2 . PHE A 1 311 ? -52.538 11.859 -6.510 1.00 58.49 ? 312 PHE A CE2 1 ATOM 2442 C CZ . PHE A 1 311 ? -53.423 10.891 -6.073 1.00 57.53 ? 312 PHE A CZ 1 ATOM 2443 N N . THR A 1 312 ? -55.977 15.074 -3.299 1.00 47.45 ? 313 THR A N 1 ATOM 2444 C CA . THR A 1 312 ? -56.794 14.103 -2.601 1.00 48.46 ? 313 THR A CA 1 ATOM 2445 C C . THR A 1 312 ? -58.039 13.795 -3.387 1.00 51.10 ? 313 THR A C 1 ATOM 2446 O O . THR A 1 312 ? -58.620 14.660 -4.072 1.00 48.07 ? 313 THR A O 1 ATOM 2447 C CB . THR A 1 312 ? -57.093 14.522 -1.174 1.00 51.84 ? 313 THR A CB 1 ATOM 2448 O OG1 . THR A 1 312 ? -55.843 14.667 -0.472 1.00 58.76 ? 313 THR A OG1 1 ATOM 2449 C CG2 . THR A 1 312 ? -57.934 13.471 -0.468 1.00 51.41 ? 313 THR A CG2 1 ATOM 2450 N N . TYR A 1 313 ? -58.383 12.511 -3.344 1.00 63.14 ? 314 TYR A N 1 ATOM 2451 C CA . TYR A 1 313 ? -59.598 11.973 -3.965 1.00 69.97 ? 314 TYR A CA 1 ATOM 2452 C C . TYR A 1 313 ? -60.538 11.506 -2.882 1.00 66.71 ? 314 TYR A C 1 ATOM 2453 O O . TYR A 1 313 ? -60.126 10.796 -1.940 1.00 62.76 ? 314 TYR A O 1 ATOM 2454 C CB . TYR A 1 313 ? -59.275 10.817 -4.923 1.00 76.24 ? 314 TYR A CB 1 ATOM 2455 C CG . TYR A 1 313 ? -60.478 10.162 -5.596 1.00 82.81 ? 314 TYR A CG 1 ATOM 2456 C CD1 . TYR A 1 313 ? -60.980 10.645 -6.815 1.00 83.38 ? 314 TYR A CD1 1 ATOM 2457 C CD2 . TYR A 1 313 ? -61.104 9.036 -5.022 1.00 83.12 ? 314 TYR A CD2 1 ATOM 2458 C CE1 . TYR A 1 313 ? -62.077 10.039 -7.422 1.00 83.80 ? 314 TYR A CE1 1 ATOM 2459 C CE2 . TYR A 1 313 ? -62.199 8.431 -5.624 1.00 78.39 ? 314 TYR A CE2 1 ATOM 2460 C CZ . TYR A 1 313 ? -62.681 8.931 -6.818 1.00 81.49 ? 314 TYR A CZ 1 ATOM 2461 O OH . TYR A 1 313 ? -63.758 8.314 -7.409 1.00 83.79 ? 314 TYR A OH 1 ATOM 2462 N N . THR A 1 314 ? -61.794 11.921 -3.040 1.00 67.95 ? 315 THR A N 1 ATOM 2463 C CA . THR A 1 314 ? -62.885 11.525 -2.159 1.00 78.03 ? 315 THR A CA 1 ATOM 2464 C C . THR A 1 314 ? -63.855 10.553 -2.839 1.00 80.42 ? 315 THR A C 1 ATOM 2465 O O . THR A 1 314 ? -64.670 10.972 -3.671 1.00 80.67 ? 315 THR A O 1 ATOM 2466 C CB . THR A 1 314 ? -63.577 12.767 -1.584 1.00 79.92 ? 315 THR A CB 1 ATOM 2467 O OG1 . THR A 1 314 ? -62.815 13.184 -0.452 1.00 80.66 ? 315 THR A OG1 1 ATOM 2468 C CG2 . THR A 1 314 ? -65.056 12.502 -1.159 1.00 78.91 ? 315 THR A CG2 1 ATOM 2469 N N . PRO A 1 315 ? -63.752 9.246 -2.489 1.00 79.62 ? 316 PRO A N 1 ATOM 2470 C CA . PRO A 1 315 ? -64.658 8.245 -3.043 1.00 90.31 ? 316 PRO A CA 1 ATOM 2471 C C . PRO A 1 315 ? -66.076 8.475 -2.528 1.00 103.27 ? 316 PRO A C 1 ATOM 2472 O O . PRO A 1 315 ? -66.248 8.892 -1.377 1.00 107.63 ? 316 PRO A O 1 ATOM 2473 C CB . PRO A 1 315 ? -64.096 6.921 -2.502 1.00 79.91 ? 316 PRO A CB 1 ATOM 2474 C CG . PRO A 1 315 ? -63.374 7.290 -1.255 1.00 77.24 ? 316 PRO A CG 1 ATOM 2475 C CD . PRO A 1 315 ? -62.828 8.661 -1.494 1.00 75.57 ? 316 PRO A CD 1 ATOM 2476 N N . ALA A 1 316 ? -67.078 8.227 -3.368 1.00 114.78 ? 317 ALA A N 1 ATOM 2477 C CA . ALA A 1 316 ? -68.462 8.222 -2.901 1.00 135.31 ? 317 ALA A CA 1 ATOM 2478 C C . ALA A 1 316 ? -68.733 6.939 -2.067 1.00 147.84 ? 317 ALA A C 1 ATOM 2479 O O . ALA A 1 316 ? -69.454 6.031 -2.506 1.00 155.86 ? 317 ALA A O 1 ATOM 2480 C CB . ALA A 1 316 ? -69.418 8.362 -4.082 1.00 140.89 ? 317 ALA A CB 1 ATOM 2481 N N . GLN A 1 317 ? -68.136 6.885 -0.865 1.00 157.90 ? 318 GLN A N 1 ATOM 2482 C CA . GLN A 1 317 ? -68.105 5.682 -0.011 1.00 148.08 ? 318 GLN A CA 1 ATOM 2483 C C . GLN A 1 317 ? -68.380 6.127 1.636 1.00 145.97 ? 318 GLN A C 1 ATOM 2484 O O . GLN A 1 317 ? -69.544 6.776 1.710 1.00 166.52 ? 318 GLN A O 1 ATOM 2485 N N . ASN A 1 321 ? -72.069 6.125 -3.697 1.00 134.84 ? 322 ASN A N 1 ATOM 2486 C CA . ASN A 1 321 ? -73.287 6.849 -4.051 1.00 147.05 ? 322 ASN A CA 1 ATOM 2487 C C . ASN A 1 321 ? -73.588 6.767 -5.561 1.00 157.99 ? 322 ASN A C 1 ATOM 2488 O O . ASN A 1 321 ? -74.050 5.726 -6.043 1.00 162.99 ? 322 ASN A O 1 ATOM 2489 C CB . ASN A 1 321 ? -73.229 8.311 -3.550 1.00 132.44 ? 322 ASN A CB 1 ATOM 2490 C CG . ASN A 1 321 ? -73.119 8.421 -2.034 1.00 122.28 ? 322 ASN A CG 1 ATOM 2491 O OD1 . ASN A 1 321 ? -73.776 7.692 -1.286 1.00 107.95 ? 322 ASN A OD1 1 ATOM 2492 N ND2 . ASN A 1 321 ? -72.292 9.356 -1.576 1.00 122.02 ? 322 ASN A ND2 1 ATOM 2493 N N . GLU A 1 322 ? -73.317 7.856 -6.290 1.00 161.17 ? 323 GLU A N 1 ATOM 2494 C CA . GLU A 1 322 ? -73.540 7.951 -7.742 1.00 151.15 ? 323 GLU A CA 1 ATOM 2495 C C . GLU A 1 322 ? -72.301 7.479 -8.511 1.00 147.59 ? 323 GLU A C 1 ATOM 2496 O O . GLU A 1 322 ? -72.297 7.462 -9.749 1.00 145.03 ? 323 GLU A O 1 ATOM 2497 C CB . GLU A 1 322 ? -73.912 9.389 -8.166 1.00 148.00 ? 323 GLU A CB 1 ATOM 2498 C CG . GLU A 1 322 ? -75.055 10.050 -7.394 1.00 153.86 ? 323 GLU A CG 1 ATOM 2499 C CD . GLU A 1 322 ? -74.641 10.587 -6.021 1.00 169.14 ? 323 GLU A CD 1 ATOM 2500 O OE1 . GLU A 1 322 ? -73.459 10.952 -5.827 1.00 167.43 ? 323 GLU A OE1 1 ATOM 2501 O OE2 . GLU A 1 322 ? -75.502 10.642 -5.118 1.00 176.37 ? 323 GLU A OE2 1 ATOM 2502 N N . GLY A 1 323 ? -71.256 7.103 -7.766 1.00 142.72 ? 324 GLY A N 1 ATOM 2503 C CA . GLY A 1 323 ? -70.006 6.576 -8.325 1.00 131.43 ? 324 GLY A CA 1 ATOM 2504 C C . GLY A 1 323 ? -68.866 7.578 -8.456 1.00 120.40 ? 324 GLY A C 1 ATOM 2505 O O . GLY A 1 323 ? -67.708 7.234 -8.203 1.00 112.18 ? 324 GLY A O 1 ATOM 2506 N N . LYS A 1 324 ? -69.200 8.809 -8.859 1.00 113.46 ? 325 LYS A N 1 ATOM 2507 C CA . LYS A 1 324 ? -68.218 9.876 -9.113 1.00 95.33 ? 325 LYS A CA 1 ATOM 2508 C C . LYS A 1 324 ? -67.681 10.580 -7.858 1.00 92.22 ? 325 LYS A C 1 ATOM 2509 O O . LYS A 1 324 ? -68.411 11.203 -7.059 1.00 80.85 ? 325 LYS A O 1 ATOM 2510 C CB . LYS A 1 324 ? -68.744 10.887 -10.132 1.00 89.00 ? 325 LYS A CB 1 ATOM 2511 C CG . LYS A 1 324 ? -68.200 10.709 -11.546 1.00 88.25 ? 325 LYS A CG 1 ATOM 2512 C CD . LYS A 1 324 ? -69.200 11.133 -12.627 1.00 98.27 ? 325 LYS A CD 1 ATOM 2513 C CE . LYS A 1 324 ? -69.572 12.624 -12.625 1.00 95.40 ? 325 LYS A CE 1 ATOM 2514 N NZ . LYS A 1 324 ? -70.695 13.017 -11.714 1.00 86.72 ? 325 LYS A NZ 1 ATOM 2515 N N . GLY A 1 325 ? -66.369 10.457 -7.715 1.00 89.72 ? 326 GLY A N 1 ATOM 2516 C CA . GLY A 1 325 ? -65.648 11.046 -6.624 1.00 86.72 ? 326 GLY A CA 1 ATOM 2517 C C . GLY A 1 325 ? -65.370 12.488 -6.938 1.00 90.41 ? 326 GLY A C 1 ATOM 2518 O O . GLY A 1 325 ? -65.590 12.949 -8.082 1.00 85.36 ? 326 GLY A O 1 ATOM 2519 N N . LYS A 1 326 ? -64.912 13.195 -5.902 1.00 87.27 ? 327 LYS A N 1 ATOM 2520 C CA . LYS A 1 326 ? -64.387 14.546 -6.035 1.00 73.09 ? 327 LYS A CA 1 ATOM 2521 C C . LYS A 1 326 ? -62.878 14.453 -5.936 1.00 66.62 ? 327 LYS A C 1 ATOM 2522 O O . LYS A 1 326 ? -62.323 13.853 -5.003 1.00 62.23 ? 327 LYS A O 1 ATOM 2523 C CB . LYS A 1 326 ? -64.954 15.503 -4.973 1.00 74.71 ? 327 LYS A CB 1 ATOM 2524 C CG . LYS A 1 326 ? -66.459 15.443 -4.712 1.00 78.45 ? 327 LYS A CG 1 ATOM 2525 C CD . LYS A 1 326 ? -67.331 15.833 -5.908 1.00 79.91 ? 327 LYS A CD 1 ATOM 2526 C CE . LYS A 1 326 ? -68.806 15.552 -5.627 1.00 76.44 ? 327 LYS A CE 1 ATOM 2527 N NZ . LYS A 1 326 ? -69.680 15.829 -6.800 1.00 71.85 ? 327 LYS A NZ 1 ATOM 2528 N N . CYS A 1 327 ? -62.234 15.024 -6.942 1.00 67.03 ? 328 CYS A N 1 ATOM 2529 C CA . CYS A 1 327 ? -60.790 15.064 -7.039 1.00 73.26 ? 328 CYS A CA 1 ATOM 2530 C C . CYS A 1 327 ? -60.351 16.494 -6.724 1.00 73.32 ? 328 CYS A C 1 ATOM 2531 O O . CYS A 1 327 ? -60.684 17.449 -7.470 1.00 66.41 ? 328 CYS A O 1 ATOM 2532 C CB . CYS A 1 327 ? -60.371 14.622 -8.451 1.00 77.73 ? 328 CYS A CB 1 ATOM 2533 S SG . CYS A 1 327 ? -58.599 14.500 -8.800 1.00 84.77 ? 328 CYS A SG 1 ATOM 2534 N N . TYR A 1 328 ? -59.643 16.641 -5.599 1.00 65.30 ? 329 TYR A N 1 ATOM 2535 C CA . TYR A 1 328 ? -59.111 17.943 -5.184 1.00 61.08 ? 329 TYR A CA 1 ATOM 2536 C C . TYR A 1 328 ? -57.654 18.054 -5.585 1.00 55.71 ? 329 TYR A C 1 ATOM 2537 O O . TYR A 1 328 ? -56.776 17.448 -4.972 1.00 53.44 ? 329 TYR A O 1 ATOM 2538 C CB . TYR A 1 328 ? -59.190 18.136 -3.674 1.00 66.38 ? 329 TYR A CB 1 ATOM 2539 C CG . TYR A 1 328 ? -60.564 18.233 -3.011 1.00 79.03 ? 329 TYR A CG 1 ATOM 2540 C CD1 . TYR A 1 328 ? -61.524 17.217 -3.140 1.00 75.85 ? 329 TYR A CD1 1 ATOM 2541 C CD2 . TYR A 1 328 ? -60.858 19.310 -2.156 1.00 82.56 ? 329 TYR A CD2 1 ATOM 2542 C CE1 . TYR A 1 328 ? -62.736 17.300 -2.478 1.00 78.72 ? 329 TYR A CE1 1 ATOM 2543 C CE2 . TYR A 1 328 ? -62.067 19.401 -1.488 1.00 76.04 ? 329 TYR A CE2 1 ATOM 2544 C CZ . TYR A 1 328 ? -63.000 18.398 -1.656 1.00 84.06 ? 329 TYR A CZ 1 ATOM 2545 O OH . TYR A 1 328 ? -64.196 18.492 -0.985 1.00 92.12 ? 329 TYR A OH 1 ATOM 2546 N N . LEU A 1 329 ? -57.400 18.833 -6.619 1.00 52.99 ? 330 LEU A N 1 ATOM 2547 C CA . LEU A 1 329 ? -56.038 19.122 -7.037 1.00 54.98 ? 330 LEU A CA 1 ATOM 2548 C C . LEU A 1 329 ? -55.439 20.277 -6.210 1.00 53.46 ? 330 LEU A C 1 ATOM 2549 O O . LEU A 1 329 ? -56.059 21.340 -6.071 1.00 50.64 ? 330 LEU A O 1 ATOM 2550 C CB . LEU A 1 329 ? -56.012 19.449 -8.535 1.00 58.77 ? 330 LEU A CB 1 ATOM 2551 C CG . LEU A 1 329 ? -56.689 18.514 -9.546 1.00 54.12 ? 330 LEU A CG 1 ATOM 2552 C CD1 . LEU A 1 329 ? -56.467 19.029 -10.966 1.00 49.85 ? 330 LEU A CD1 1 ATOM 2553 C CD2 . LEU A 1 329 ? -56.214 17.075 -9.373 1.00 53.41 ? 330 LEU A CD2 1 ATOM 2554 N N . LYS A 1 330 ? -54.232 20.055 -5.683 1.00 51.02 ? 331 LYS A N 1 ATOM 2555 C CA . LYS A 1 330 ? -53.626 20.944 -4.683 1.00 53.89 ? 331 LYS A CA 1 ATOM 2556 C C . LYS A 1 330 ? -52.169 21.344 -4.954 1.00 52.71 ? 331 LYS A C 1 ATOM 2557 O O . LYS A 1 330 ? -51.481 20.727 -5.763 1.00 63.33 ? 331 LYS A O 1 ATOM 2558 C CB . LYS A 1 330 ? -53.713 20.280 -3.310 1.00 53.93 ? 331 LYS A CB 1 ATOM 2559 C CG . LYS A 1 330 ? -55.131 19.982 -2.845 1.00 52.87 ? 331 LYS A CG 1 ATOM 2560 C CD . LYS A 1 330 ? -55.132 19.330 -1.477 1.00 49.38 ? 331 LYS A CD 1 ATOM 2561 C CE . LYS A 1 330 ? -56.518 18.852 -1.127 1.00 47.52 ? 331 LYS A CE 1 ATOM 2562 N NZ . LYS A 1 330 ? -56.420 17.905 -0.001 1.00 46.59 ? 331 LYS A NZ 1 ATOM 2563 N N . LEU A 1 331 ? -51.702 22.382 -4.275 1.00 48.68 ? 332 LEU A N 1 ATOM 2564 C CA . LEU A 1 331 ? -50.268 22.754 -4.294 1.00 47.08 ? 332 LEU A CA 1 ATOM 2565 C C . LEU A 1 331 ? -49.835 23.357 -2.953 1.00 46.96 ? 332 LEU A C 1 ATOM 2566 O O . LEU A 1 331 ? -50.679 23.680 -2.123 1.00 49.83 ? 332 LEU A O 1 ATOM 2567 C CB . LEU A 1 331 ? -49.964 23.737 -5.433 1.00 38.95 ? 332 LEU A CB 1 ATOM 2568 C CG . LEU A 1 331 ? -50.604 25.106 -5.357 1.00 33.21 ? 332 LEU A CG 1 ATOM 2569 C CD1 . LEU A 1 331 ? -49.630 26.123 -4.847 1.00 35.42 ? 332 LEU A CD1 1 ATOM 2570 C CD2 . LEU A 1 331 ? -50.927 25.469 -6.754 1.00 33.37 ? 332 LEU A CD2 1 ATOM 2571 N N . SER A 1 332 ? -48.530 23.524 -2.758 1.00 45.21 ? 333 SER A N 1 ATOM 2572 C CA . SER A 1 332 ? -48.002 24.243 -1.595 1.00 43.45 ? 333 SER A CA 1 ATOM 2573 C C . SER A 1 332 ? -46.732 25.025 -1.926 1.00 44.60 ? 333 SER A C 1 ATOM 2574 O O . SER A 1 332 ? -46.312 25.113 -3.096 1.00 41.31 ? 333 SER A O 1 ATOM 2575 C CB . SER A 1 332 ? -47.724 23.273 -0.461 1.00 41.79 ? 333 SER A CB 1 ATOM 2576 O OG . SER A 1 332 ? -46.571 22.507 -0.746 1.00 38.36 ? 333 SER A OG 1 ATOM 2577 N N . SER A 1 333 ? -46.122 25.577 -0.884 1.00 48.37 ? 334 SER A N 1 ATOM 2578 C CA . SER A 1 333 ? -44.918 26.365 -1.032 1.00 51.76 ? 334 SER A CA 1 ATOM 2579 C C . SER A 1 333 ? -43.703 25.559 -1.392 1.00 51.25 ? 334 SER A C 1 ATOM 2580 O O . SER A 1 333 ? -42.999 25.950 -2.294 1.00 54.56 ? 334 SER A O 1 ATOM 2581 C CB . SER A 1 333 ? -44.651 27.176 0.207 1.00 57.16 ? 334 SER A CB 1 ATOM 2582 O OG . SER A 1 333 ? -45.134 28.458 -0.101 1.00 81.60 ? 334 SER A OG 1 ATOM 2583 N N . ASN A 1 334 ? -43.439 24.472 -0.666 1.00 47.71 ? 335 ASN A N 1 ATOM 2584 C CA . ASN A 1 334 ? -42.487 23.461 -1.086 1.00 44.95 ? 335 ASN A CA 1 ATOM 2585 C C . ASN A 1 334 ? -43.323 22.449 -1.833 1.00 49.50 ? 335 ASN A C 1 ATOM 2586 O O . ASN A 1 334 ? -44.482 22.710 -2.143 1.00 55.98 ? 335 ASN A O 1 ATOM 2587 C CB . ASN A 1 334 ? -41.846 22.824 0.120 1.00 43.66 ? 335 ASN A CB 1 ATOM 2588 C CG . ASN A 1 334 ? -42.850 22.452 1.167 1.00 48.11 ? 335 ASN A CG 1 ATOM 2589 O OD1 . ASN A 1 334 ? -44.015 22.204 0.866 1.00 56.47 ? 335 ASN A OD1 1 ATOM 2590 N ND2 . ASN A 1 334 ? -42.414 22.418 2.416 1.00 52.34 ? 335 ASN A ND2 1 ATOM 2591 N N . GLY A 1 335 ? -42.819 21.271 -2.105 1.00 46.36 ? 336 GLY A N 1 ATOM 2592 C CA . GLY A 1 335 ? -43.678 20.433 -2.916 1.00 50.33 ? 336 GLY A CA 1 ATOM 2593 C C . GLY A 1 335 ? -44.690 19.618 -2.144 1.00 52.52 ? 336 GLY A C 1 ATOM 2594 O O . GLY A 1 335 ? -45.229 18.657 -2.682 1.00 56.13 ? 336 GLY A O 1 ATOM 2595 N N . SER A 1 336 ? -44.955 19.992 -0.897 1.00 51.00 ? 337 SER A N 1 ATOM 2596 C CA . SER A 1 336 ? -45.462 19.037 0.074 1.00 48.44 ? 337 SER A CA 1 ATOM 2597 C C . SER A 1 336 ? -46.673 19.537 0.875 1.00 49.27 ? 337 SER A C 1 ATOM 2598 O O . SER A 1 336 ? -46.762 20.733 1.148 1.00 55.49 ? 337 SER A O 1 ATOM 2599 C CB . SER A 1 336 ? -44.317 18.709 1.019 1.00 50.96 ? 337 SER A CB 1 ATOM 2600 O OG . SER A 1 336 ? -44.183 17.303 1.143 1.00 57.86 ? 337 SER A OG 1 ATOM 2601 N N . PRO A 1 337 ? -47.590 18.630 1.296 1.00 46.44 ? 338 PRO A N 1 ATOM 2602 C CA . PRO A 1 337 ? -48.748 19.078 2.108 1.00 45.87 ? 338 PRO A CA 1 ATOM 2603 C C . PRO A 1 337 ? -48.319 19.880 3.314 1.00 43.73 ? 338 PRO A C 1 ATOM 2604 O O . PRO A 1 337 ? -47.203 19.685 3.821 1.00 46.60 ? 338 PRO A O 1 ATOM 2605 C CB . PRO A 1 337 ? -49.394 17.785 2.623 1.00 45.28 ? 338 PRO A CB 1 ATOM 2606 C CG . PRO A 1 337 ? -48.631 16.679 2.033 1.00 46.40 ? 338 PRO A CG 1 ATOM 2607 C CD . PRO A 1 337 ? -47.494 17.166 1.206 1.00 44.46 ? 338 PRO A CD 1 ATOM 2608 N N . THR A 1 338 ? -49.213 20.741 3.782 1.00 38.78 ? 339 THR A N 1 ATOM 2609 C CA . THR A 1 338 ? -48.930 21.609 4.906 1.00 40.02 ? 339 THR A CA 1 ATOM 2610 C C . THR A 1 338 ? -49.287 20.860 6.170 1.00 45.78 ? 339 THR A C 1 ATOM 2611 O O . THR A 1 338 ? -48.769 21.163 7.240 1.00 46.08 ? 339 THR A O 1 ATOM 2612 C CB . THR A 1 338 ? -49.736 22.894 4.822 1.00 39.34 ? 339 THR A CB 1 ATOM 2613 O OG1 . THR A 1 338 ? -51.111 22.553 4.732 1.00 54.33 ? 339 THR A OG1 1 ATOM 2614 C CG2 . THR A 1 338 ? -49.446 23.624 3.572 1.00 38.11 ? 339 THR A CG2 1 ATOM 2615 N N . LYS A 1 339 ? -50.179 19.871 6.025 1.00 58.54 ? 340 LYS A N 1 ATOM 2616 C CA . LYS A 1 339 ? -50.628 18.954 7.102 1.00 59.94 ? 340 LYS A CA 1 ATOM 2617 C C . LYS A 1 339 ? -51.067 17.646 6.474 1.00 56.79 ? 340 LYS A C 1 ATOM 2618 O O . LYS A 1 339 ? -51.713 17.638 5.426 1.00 56.87 ? 340 LYS A O 1 ATOM 2619 C CB . LYS A 1 339 ? -51.812 19.555 7.890 1.00 63.11 ? 340 LYS A CB 1 ATOM 2620 C CG . LYS A 1 339 ? -52.142 18.923 9.244 1.00 66.56 ? 340 LYS A CG 1 ATOM 2621 C CD . LYS A 1 339 ? -50.910 18.850 10.140 1.00 75.14 ? 340 LYS A CD 1 ATOM 2622 C CE . LYS A 1 339 ? -51.243 18.580 11.592 1.00 71.32 ? 340 LYS A CE 1 ATOM 2623 N NZ . LYS A 1 339 ? -50.069 17.883 12.179 1.00 73.44 ? 340 LYS A NZ 1 ATOM 2624 N N . ILE A 1 340 ? -50.706 16.541 7.111 1.00 59.57 ? 341 ILE A N 1 ATOM 2625 C CA . ILE A 1 340 ? -51.174 15.220 6.672 1.00 56.91 ? 341 ILE A CA 1 ATOM 2626 C C . ILE A 1 340 ? -52.150 14.660 7.716 1.00 59.87 ? 341 ILE A C 1 ATOM 2627 O O . ILE A 1 340 ? -51.754 14.394 8.869 1.00 60.69 ? 341 ILE A O 1 ATOM 2628 C CB . ILE A 1 340 ? -49.988 14.274 6.400 1.00 50.01 ? 341 ILE A CB 1 ATOM 2629 C CG1 . ILE A 1 340 ? -49.311 14.683 5.099 1.00 45.09 ? 341 ILE A CG1 1 ATOM 2630 C CG2 . ILE A 1 340 ? -50.424 12.810 6.371 1.00 50.43 ? 341 ILE A CG2 1 ATOM 2631 C CD1 . ILE A 1 340 ? -47.934 14.083 4.905 1.00 42.44 ? 341 ILE A CD1 1 ATOM 2632 N N . LEU A 1 341 ? -53.413 14.498 7.301 1.00 56.47 ? 342 LEU A N 1 ATOM 2633 C CA . LEU A 1 341 ? -54.497 14.078 8.196 1.00 54.27 ? 342 LEU A CA 1 ATOM 2634 C C . LEU A 1 341 ? -55.010 12.702 7.863 1.00 60.52 ? 342 LEU A C 1 ATOM 2635 O O . LEU A 1 341 ? -55.317 12.414 6.691 1.00 66.22 ? 342 LEU A O 1 ATOM 2636 C CB . LEU A 1 341 ? -55.675 15.030 8.088 1.00 48.97 ? 342 LEU A CB 1 ATOM 2637 C CG . LEU A 1 341 ? -55.592 16.452 8.596 1.00 47.52 ? 342 LEU A CG 1 ATOM 2638 C CD1 . LEU A 1 341 ? -56.980 17.016 8.424 1.00 50.75 ? 342 LEU A CD1 1 ATOM 2639 C CD2 . LEU A 1 341 ? -55.153 16.561 10.052 1.00 44.50 ? 342 LEU A CD2 1 ATOM 2640 N N . HIS A 1 342 ? -55.125 11.868 8.893 1.00 59.55 ? 343 HIS A N 1 ATOM 2641 C CA . HIS A 1 342 ? -55.677 10.536 8.728 1.00 63.77 ? 343 HIS A CA 1 ATOM 2642 C C . HIS A 1 342 ? -57.078 10.493 9.293 1.00 73.39 ? 343 HIS A C 1 ATOM 2643 O O . HIS A 1 342 ? -57.365 11.176 10.277 1.00 82.91 ? 343 HIS A O 1 ATOM 2644 C CB . HIS A 1 342 ? -54.817 9.516 9.449 1.00 60.96 ? 343 HIS A CB 1 ATOM 2645 C CG . HIS A 1 342 ? -53.357 9.741 9.275 1.00 62.34 ? 343 HIS A CG 1 ATOM 2646 N ND1 . HIS A 1 342 ? -52.731 9.640 8.048 1.00 63.97 ? 343 HIS A ND1 1 ATOM 2647 C CD2 . HIS A 1 342 ? -52.396 10.072 10.169 1.00 61.13 ? 343 HIS A CD2 1 ATOM 2648 C CE1 . HIS A 1 342 ? -51.444 9.898 8.195 1.00 64.79 ? 343 HIS A CE1 1 ATOM 2649 N NE2 . HIS A 1 342 ? -51.215 10.167 9.471 1.00 67.26 ? 343 HIS A NE2 1 ATOM 2650 N N . GLY A 1 343 ? -57.947 9.696 8.672 1.00 76.09 ? 344 GLY A N 1 ATOM 2651 C CA . GLY A 1 343 ? -59.253 9.365 9.256 1.00 67.53 ? 344 GLY A CA 1 ATOM 2652 C C . GLY A 1 343 ? -60.411 10.126 8.654 1.00 64.63 ? 344 GLY A C 1 ATOM 2653 O O . GLY A 1 343 ? -61.412 10.342 9.315 1.00 67.82 ? 344 GLY A O 1 ATOM 2654 N N . ARG A 1 344 ? -60.268 10.562 7.410 1.00 61.23 ? 345 ARG A N 1 ATOM 2655 C CA . ARG A 1 344 ? -61.287 11.396 6.777 1.00 56.52 ? 345 ARG A CA 1 ATOM 2656 C C . ARG A 1 344 ? -61.629 10.836 5.395 1.00 60.81 ? 345 ARG A C 1 ATOM 2657 O O . ARG A 1 344 ? -62.338 11.470 4.623 1.00 63.64 ? 345 ARG A O 1 ATOM 2658 C CB . ARG A 1 344 ? -60.844 12.881 6.716 1.00 52.05 ? 345 ARG A CB 1 ATOM 2659 C CG . ARG A 1 344 ? -61.057 13.729 7.978 1.00 50.84 ? 345 ARG A CG 1 ATOM 2660 C CD . ARG A 1 344 ? -59.956 13.557 9.035 1.00 54.60 ? 345 ARG A CD 1 ATOM 2661 N NE . ARG A 1 344 ? -59.902 14.678 9.987 1.00 63.28 ? 345 ARG A NE 1 ATOM 2662 C CZ . ARG A 1 344 ? -59.023 14.824 10.990 1.00 63.22 ? 345 ARG A CZ 1 ATOM 2663 N NH1 . ARG A 1 344 ? -58.077 13.924 11.208 1.00 65.03 ? 345 ARG A NH1 1 ATOM 2664 N NH2 . ARG A 1 344 ? -59.087 15.885 11.791 1.00 59.74 ? 345 ARG A NH2 1 ATOM 2665 N N . GLY A 1 345 ? -61.102 9.651 5.088 1.00 64.46 ? 346 GLY A N 1 ATOM 2666 C CA . GLY A 1 345 ? -61.547 8.853 3.954 1.00 68.79 ? 346 GLY A CA 1 ATOM 2667 C C . GLY A 1 345 ? -61.039 9.179 2.564 1.00 78.99 ? 346 GLY A C 1 ATOM 2668 O O . GLY A 1 345 ? -61.585 8.677 1.558 1.00 86.88 ? 346 GLY A O 1 ATOM 2669 N N . GLY A 1 346 ? -59.997 9.997 2.486 1.00 78.70 ? 347 GLY A N 1 ATOM 2670 C CA . GLY A 1 346 ? -59.467 10.389 1.182 1.00 77.25 ? 347 GLY A CA 1 ATOM 2671 C C . GLY A 1 346 ? -58.345 9.491 0.693 1.00 70.25 ? 347 GLY A C 1 ATOM 2672 O O . GLY A 1 346 ? -57.675 8.813 1.492 1.00 67.99 ? 347 GLY A O 1 ATOM 2673 N N . ILE A 1 347 ? -58.141 9.493 -0.620 1.00 62.11 ? 348 ILE A N 1 ATOM 2674 C CA . ILE A 1 347 ? -56.951 8.879 -1.187 1.00 61.64 ? 348 ILE A CA 1 ATOM 2675 C C . ILE A 1 347 ? -56.063 9.981 -1.721 1.00 56.34 ? 348 ILE A C 1 ATOM 2676 O O . ILE A 1 347 ? -56.471 10.775 -2.576 1.00 51.13 ? 348 ILE A O 1 ATOM 2677 C CB . ILE A 1 347 ? -57.286 7.876 -2.302 1.00 70.75 ? 348 ILE A CB 1 ATOM 2678 C CG1 . ILE A 1 347 ? -58.241 6.790 -1.774 1.00 74.77 ? 348 ILE A CG1 1 ATOM 2679 C CG2 . ILE A 1 347 ? -56.007 7.261 -2.867 1.00 68.51 ? 348 ILE A CG2 1 ATOM 2680 C CD1 . ILE A 1 347 ? -59.390 6.458 -2.706 1.00 68.12 ? 348 ILE A CD1 1 ATOM 2681 N N . SER A 1 348 ? -54.847 10.016 -1.199 1.00 57.03 ? 349 SER A N 1 ATOM 2682 C CA . SER A 1 348 ? -53.878 11.028 -1.555 1.00 59.24 ? 349 SER A CA 1 ATOM 2683 C C . SER A 1 348 ? -52.668 10.416 -2.224 1.00 65.36 ? 349 SER A C 1 ATOM 2684 O O . SER A 1 348 ? -52.271 9.284 -1.923 1.00 61.90 ? 349 SER A O 1 ATOM 2685 C CB . SER A 1 348 ? -53.436 11.794 -0.314 1.00 57.07 ? 349 SER A CB 1 ATOM 2686 O OG . SER A 1 348 ? -54.462 12.669 0.111 1.00 66.64 ? 349 SER A OG 1 ATOM 2687 N N . GLY A 1 349 ? -52.101 11.187 -3.146 1.00 69.17 ? 350 GLY A N 1 ATOM 2688 C CA . GLY A 1 349 ? -50.735 10.983 -3.618 1.00 69.12 ? 350 GLY A CA 1 ATOM 2689 C C . GLY A 1 349 ? -50.198 12.253 -4.252 1.00 60.98 ? 350 GLY A C 1 ATOM 2690 O O . GLY A 1 349 ? -50.607 13.350 -3.896 1.00 66.30 ? 350 GLY A O 1 ATOM 2691 N N . TYR A 1 350 ? -49.331 12.087 -5.240 1.00 55.93 ? 351 TYR A N 1 ATOM 2692 C CA . TYR A 1 350 ? -48.578 13.185 -5.812 1.00 53.49 ? 351 TYR A CA 1 ATOM 2693 C C . TYR A 1 350 ? -48.711 13.192 -7.322 1.00 56.53 ? 351 TYR A C 1 ATOM 2694 O O . TYR A 1 350 ? -49.179 12.212 -7.913 1.00 64.29 ? 351 TYR A O 1 ATOM 2695 C CB . TYR A 1 350 ? -47.089 13.027 -5.462 1.00 53.81 ? 351 TYR A CB 1 ATOM 2696 C CG . TYR A 1 350 ? -46.768 13.029 -3.983 1.00 50.22 ? 351 TYR A CG 1 ATOM 2697 C CD1 . TYR A 1 350 ? -46.421 14.222 -3.338 1.00 46.62 ? 351 TYR A CD1 1 ATOM 2698 C CD2 . TYR A 1 350 ? -46.791 11.839 -3.228 1.00 47.30 ? 351 TYR A CD2 1 ATOM 2699 C CE1 . TYR A 1 350 ? -46.137 14.244 -1.982 1.00 43.54 ? 351 TYR A CE1 1 ATOM 2700 C CE2 . TYR A 1 350 ? -46.496 11.854 -1.863 1.00 47.80 ? 351 TYR A CE2 1 ATOM 2701 C CZ . TYR A 1 350 ? -46.177 13.065 -1.250 1.00 44.57 ? 351 TYR A CZ 1 ATOM 2702 O OH . TYR A 1 350 ? -45.879 13.115 0.085 1.00 42.01 ? 351 TYR A OH 1 ATOM 2703 N N . THR A 1 351 ? -48.273 14.292 -7.939 1.00 54.01 ? 352 THR A N 1 ATOM 2704 C CA . THR A 1 351 ? -48.187 14.409 -9.384 1.00 51.71 ? 352 THR A CA 1 ATOM 2705 C C . THR A 1 351 ? -47.068 13.502 -9.841 1.00 58.94 ? 352 THR A C 1 ATOM 2706 O O . THR A 1 351 ? -46.065 13.299 -9.125 1.00 69.28 ? 352 THR A O 1 ATOM 2707 C CB . THR A 1 351 ? -48.002 15.878 -9.843 1.00 50.15 ? 352 THR A CB 1 ATOM 2708 O OG1 . THR A 1 351 ? -48.014 15.984 -11.279 1.00 49.08 ? 352 THR A OG1 1 ATOM 2709 C CG2 . THR A 1 351 ? -46.746 16.490 -9.288 1.00 48.35 ? 352 THR A CG2 1 ATOM 2710 N N . LEU A 1 352 ? -47.270 12.905 -11.010 1.00 62.85 ? 353 LEU A N 1 ATOM 2711 C CA . LEU A 1 352 ? -46.238 12.087 -11.626 1.00 57.75 ? 353 LEU A CA 1 ATOM 2712 C C . LEU A 1 352 ? -45.470 12.887 -12.652 1.00 58.11 ? 353 LEU A C 1 ATOM 2713 O O . LEU A 1 352 ? -44.453 12.427 -13.150 1.00 65.83 ? 353 LEU A O 1 ATOM 2714 C CB . LEU A 1 352 ? -46.828 10.837 -12.242 1.00 57.99 ? 353 LEU A CB 1 ATOM 2715 C CG . LEU A 1 352 ? -47.541 9.833 -11.340 1.00 59.38 ? 353 LEU A CG 1 ATOM 2716 C CD1 . LEU A 1 352 ? -47.971 8.709 -12.250 1.00 57.76 ? 353 LEU A CD1 1 ATOM 2717 C CD2 . LEU A 1 352 ? -46.678 9.298 -10.198 1.00 61.90 ? 353 LEU A CD2 1 ATOM 2718 N N . ARG A 1 353 ? -45.940 14.099 -12.942 1.00 58.38 ? 354 ARG A N 1 ATOM 2719 C CA . ARG A 1 353 ? -45.171 15.113 -13.671 1.00 60.47 ? 354 ARG A CA 1 ATOM 2720 C C . ARG A 1 353 ? -43.689 15.154 -13.186 1.00 67.37 ? 354 ARG A C 1 ATOM 2721 O O . ARG A 1 353 ? -42.793 15.626 -13.875 1.00 69.76 ? 354 ARG A O 1 ATOM 2722 C CB . ARG A 1 353 ? -45.925 16.447 -13.524 1.00 63.38 ? 354 ARG A CB 1 ATOM 2723 C CG . ARG A 1 353 ? -45.350 17.694 -14.174 1.00 70.93 ? 354 ARG A CG 1 ATOM 2724 C CD . ARG A 1 353 ? -44.503 18.491 -13.183 1.00 78.70 ? 354 ARG A CD 1 ATOM 2725 N NE . ARG A 1 353 ? -45.262 19.343 -12.258 1.00 82.35 ? 354 ARG A NE 1 ATOM 2726 C CZ . ARG A 1 353 ? -44.823 19.739 -11.060 1.00 83.70 ? 354 ARG A CZ 1 ATOM 2727 N NH1 . ARG A 1 353 ? -43.641 19.341 -10.613 1.00 90.70 ? 354 ARG A NH1 1 ATOM 2728 N NH2 . ARG A 1 353 ? -45.562 20.535 -10.298 1.00 87.97 ? 354 ARG A NH2 1 ATOM 2729 N N . LEU A 1 354 ? -43.450 14.609 -12.000 1.00 80.33 ? 355 LEU A N 1 ATOM 2730 C CA . LEU A 1 354 ? -42.130 14.573 -11.389 1.00 92.16 ? 355 LEU A CA 1 ATOM 2731 C C . LEU A 1 354 ? -41.262 13.380 -11.812 1.00 93.98 ? 355 LEU A C 1 ATOM 2732 O O . LEU A 1 354 ? -40.047 13.437 -11.629 1.00 101.66 ? 355 LEU A O 1 ATOM 2733 C CB . LEU A 1 354 ? -42.261 14.563 -9.854 1.00 97.25 ? 355 LEU A CB 1 ATOM 2734 C CG . LEU A 1 354 ? -42.540 15.749 -8.913 1.00 86.31 ? 355 LEU A CG 1 ATOM 2735 C CD1 . LEU A 1 354 ? -42.691 15.237 -7.479 1.00 80.28 ? 355 LEU A CD1 1 ATOM 2736 C CD2 . LEU A 1 354 ? -41.458 16.817 -8.977 1.00 81.28 ? 355 LEU A CD2 1 ATOM 2737 N N . CYS A 1 355 ? -41.859 12.305 -12.344 1.00 92.38 ? 356 CYS A N 1 ATOM 2738 C CA . CYS A 1 355 ? -41.079 11.082 -12.661 1.00 84.57 ? 356 CYS A CA 1 ATOM 2739 C C . CYS A 1 355 ? -40.137 11.325 -13.817 1.00 76.75 ? 356 CYS A C 1 ATOM 2740 O O . CYS A 1 355 ? -39.073 10.743 -13.854 1.00 75.26 ? 356 CYS A O 1 ATOM 2741 C CB . CYS A 1 355 ? -41.925 9.812 -12.926 1.00 82.70 ? 356 CYS A CB 1 ATOM 2742 S SG . CYS A 1 355 ? -43.240 9.462 -11.739 1.00 92.10 ? 356 CYS A SG 1 ATOM 2743 N N . LYS A 1 356 ? -40.511 12.211 -14.734 1.00 77.26 ? 357 LYS A N 1 ATOM 2744 C CA . LYS A 1 356 ? -39.668 12.531 -15.883 1.00 79.12 ? 357 LYS A CA 1 ATOM 2745 C C . LYS A 1 356 ? -38.235 12.966 -15.514 1.00 84.62 ? 357 LYS A C 1 ATOM 2746 O O . LYS A 1 356 ? -37.322 12.877 -16.345 1.00 83.47 ? 357 LYS A O 1 ATOM 2747 C CB . LYS A 1 356 ? -40.373 13.551 -16.790 1.00 81.26 ? 357 LYS A CB 1 ATOM 2748 C CG . LYS A 1 356 ? -41.275 12.899 -17.827 1.00 94.04 ? 357 LYS A CG 1 ATOM 2749 C CD . LYS A 1 356 ? -40.504 11.868 -18.669 1.00 99.56 ? 357 LYS A CD 1 ATOM 2750 C CE . LYS A 1 356 ? -41.410 10.855 -19.362 1.00 93.85 ? 357 LYS A CE 1 ATOM 2751 N NZ . LYS A 1 356 ? -40.855 9.482 -19.225 1.00 82.48 ? 357 LYS A NZ 1 ATOM 2752 N N . MET A 1 357 ? -38.064 13.423 -14.267 1.00 91.89 ? 358 MET A N 1 ATOM 2753 C CA . MET A 1 357 ? -36.773 13.839 -13.691 1.00 94.31 ? 358 MET A CA 1 ATOM 2754 C C . MET A 1 357 ? -35.967 12.638 -13.200 1.00 88.25 ? 358 MET A C 1 ATOM 2755 O O . MET A 1 357 ? -34.733 12.691 -13.165 1.00 92.98 ? 358 MET A O 1 ATOM 2756 C CB . MET A 1 357 ? -36.977 14.817 -12.516 1.00 103.69 ? 358 MET A CB 1 ATOM 2757 C CG . MET A 1 357 ? -37.608 16.154 -12.881 1.00 113.63 ? 358 MET A CG 1 ATOM 2758 S SD . MET A 1 357 ? -38.043 17.215 -11.481 1.00 116.22 ? 358 MET A SD 1 ATOM 2759 C CE . MET A 1 357 ? -39.714 17.710 -11.968 1.00 115.32 ? 358 MET A CE 1 ATOM 2760 N N . ASP A 1 358 ? -36.680 11.586 -12.790 1.00 78.79 ? 359 ASP A N 1 ATOM 2761 C CA . ASP A 1 358 ? -36.096 10.306 -12.392 1.00 70.41 ? 359 ASP A CA 1 ATOM 2762 C C . ASP A 1 358 ? -35.561 9.526 -13.572 1.00 70.15 ? 359 ASP A C 1 ATOM 2763 O O . ASP A 1 358 ? -36.020 9.653 -14.701 1.00 71.18 ? 359 ASP A O 1 ATOM 2764 C CB . ASP A 1 358 ? -37.125 9.445 -11.670 1.00 71.21 ? 359 ASP A CB 1 ATOM 2765 C CG . ASP A 1 358 ? -37.107 9.646 -10.181 1.00 76.94 ? 359 ASP A CG 1 ATOM 2766 O OD1 . ASP A 1 358 ? -36.518 10.651 -9.703 1.00 77.99 ? 359 ASP A OD1 1 ATOM 2767 O OD2 . ASP A 1 358 ? -37.696 8.789 -9.484 1.00 77.64 ? 359 ASP A OD2 1 ATOM 2768 N N . ASN A 1 359 ? -34.578 8.696 -13.294 1.00 73.07 ? 360 ASN A N 1 ATOM 2769 C CA . ASN A 1 359 ? -33.898 7.972 -14.337 1.00 75.72 ? 360 ASN A CA 1 ATOM 2770 C C . ASN A 1 359 ? -34.832 6.828 -14.778 1.00 71.59 ? 360 ASN A C 1 ATOM 2771 O O . ASN A 1 359 ? -35.383 6.116 -13.940 1.00 61.40 ? 360 ASN A O 1 ATOM 2772 C CB . ASN A 1 359 ? -32.528 7.547 -13.778 1.00 79.26 ? 360 ASN A CB 1 ATOM 2773 C CG . ASN A 1 359 ? -31.814 6.518 -14.616 1.00 75.78 ? 360 ASN A CG 1 ATOM 2774 O OD1 . ASN A 1 359 ? -32.089 6.320 -15.802 1.00 76.12 ? 360 ASN A OD1 1 ATOM 2775 N ND2 . ASN A 1 359 ? -30.883 5.837 -13.979 1.00 74.12 ? 360 ASN A ND2 1 ATOM 2776 N N . GLU A 1 360 ? -35.017 6.691 -16.092 1.00 70.10 ? 361 GLU A N 1 ATOM 2777 C CA . GLU A 1 360 ? -36.069 5.836 -16.665 1.00 71.38 ? 361 GLU A CA 1 ATOM 2778 C C . GLU A 1 360 ? -35.997 4.321 -16.349 1.00 69.17 ? 361 GLU A C 1 ATOM 2779 O O . GLU A 1 360 ? -37.007 3.605 -16.367 1.00 69.87 ? 361 GLU A O 1 ATOM 2780 C CB . GLU A 1 360 ? -36.165 6.076 -18.162 1.00 74.08 ? 361 GLU A CB 1 ATOM 2781 C CG . GLU A 1 360 ? -37.574 5.880 -18.674 1.00 87.19 ? 361 GLU A CG 1 ATOM 2782 C CD . GLU A 1 360 ? -37.807 6.534 -20.008 1.00 95.10 ? 361 GLU A CD 1 ATOM 2783 O OE1 . GLU A 1 360 ? -36.920 7.299 -20.476 1.00 92.21 ? 361 GLU A OE1 1 ATOM 2784 O OE2 . GLU A 1 360 ? -38.894 6.269 -20.574 1.00 100.73 ? 361 GLU A OE2 1 ATOM 2785 N N . CYS A 1 361 ? -34.804 3.848 -16.035 1.00 70.06 ? 362 CYS A N 1 ATOM 2786 C CA . CYS A 1 361 ? -34.606 2.470 -15.674 1.00 67.07 ? 362 CYS A CA 1 ATOM 2787 C C . CYS A 1 361 ? -35.016 2.237 -14.224 1.00 67.88 ? 362 CYS A C 1 ATOM 2788 O O . CYS A 1 361 ? -34.800 1.139 -13.700 1.00 68.54 ? 362 CYS A O 1 ATOM 2789 C CB . CYS A 1 361 ? -33.138 2.125 -15.880 1.00 72.67 ? 362 CYS A CB 1 ATOM 2790 S SG . CYS A 1 361 ? -31.999 3.080 -14.839 1.00 74.80 ? 362 CYS A SG 1 ATOM 2791 N N . THR A 1 362 ? -35.559 3.270 -13.567 1.00 68.85 ? 363 THR A N 1 ATOM 2792 C CA . THR A 1 362 ? -36.071 3.137 -12.187 1.00 71.40 ? 363 THR A CA 1 ATOM 2793 C C . THR A 1 362 ? -37.563 2.915 -12.089 1.00 73.71 ? 363 THR A C 1 ATOM 2794 O O . THR A 1 362 ? -38.008 2.444 -11.040 1.00 73.79 ? 363 THR A O 1 ATOM 2795 C CB . THR A 1 362 ? -35.715 4.303 -11.229 1.00 68.22 ? 363 THR A CB 1 ATOM 2796 O OG1 . THR A 1 362 ? -36.015 5.559 -11.833 1.00 65.36 ? 363 THR A OG1 1 ATOM 2797 C CG2 . THR A 1 362 ? -34.280 4.266 -10.866 1.00 66.91 ? 363 THR A CG2 1 ATOM 2798 N N . THR A 1 363 ? -38.316 3.252 -13.151 1.00 73.49 ? 364 THR A N 1 ATOM 2799 C CA . THR A 1 363 ? -39.760 2.921 -13.282 1.00 80.77 ? 364 THR A CA 1 ATOM 2800 C C . THR A 1 363 ? -40.046 1.485 -12.828 1.00 84.13 ? 364 THR A C 1 ATOM 2801 O O . THR A 1 363 ? -39.250 0.567 -13.094 1.00 85.31 ? 364 THR A O 1 ATOM 2802 C CB . THR A 1 363 ? -40.296 3.086 -14.731 1.00 87.12 ? 364 THR A CB 1 ATOM 2803 O OG1 . THR A 1 363 ? -39.573 2.231 -15.620 1.00 104.57 ? 364 THR A OG1 1 ATOM 2804 C CG2 . THR A 1 363 ? -40.181 4.537 -15.240 1.00 94.98 ? 364 THR A CG2 1 ATOM 2805 N N . LYS A 1 364 ? -41.171 1.300 -12.137 1.00 89.32 ? 365 LYS A N 1 ATOM 2806 C CA . LYS A 1 364 ? -41.522 0.006 -11.526 1.00 102.86 ? 365 LYS A CA 1 ATOM 2807 C C . LYS A 1 364 ? -41.737 -1.089 -12.589 1.00 104.56 ? 365 LYS A C 1 ATOM 2808 O O . LYS A 1 364 ? -41.773 -0.805 -13.795 1.00 98.54 ? 365 LYS A O 1 ATOM 2809 C CB . LYS A 1 364 ? -42.740 0.150 -10.590 1.00 106.80 ? 365 LYS A CB 1 ATOM 2810 C CG . LYS A 1 364 ? -42.557 -0.447 -9.195 1.00 113.24 ? 365 LYS A CG 1 ATOM 2811 C CD . LYS A 1 364 ? -42.872 -1.935 -9.155 1.00 119.64 ? 365 LYS A CD 1 ATOM 2812 C CE . LYS A 1 364 ? -43.849 -2.254 -8.036 1.00 126.11 ? 365 LYS A CE 1 ATOM 2813 N NZ . LYS A 1 364 ? -44.709 -3.418 -8.387 1.00 114.17 ? 365 LYS A NZ 1 ATOM 2814 N N . ILE A 1 365 ? -41.863 -2.335 -12.145 1.00 108.84 ? 366 ILE A N 1 ATOM 2815 C CA . ILE A 1 365 ? -41.831 -3.473 -13.061 1.00 108.26 ? 366 ILE A CA 1 ATOM 2816 C C . ILE A 1 365 ? -43.206 -4.147 -13.320 1.00 116.36 ? 366 ILE A C 1 ATOM 2817 O O . ILE A 1 365 ? -43.713 -4.960 -12.534 1.00 128.45 ? 366 ILE A O 1 ATOM 2818 C CB . ILE A 1 365 ? -40.636 -4.423 -12.714 1.00 105.27 ? 366 ILE A CB 1 ATOM 2819 C CG1 . ILE A 1 365 ? -40.527 -5.610 -13.711 1.00 98.04 ? 366 ILE A CG1 1 ATOM 2820 C CG2 . ILE A 1 365 ? -40.607 -4.770 -11.210 1.00 93.42 ? 366 ILE A CG2 1 ATOM 2821 C CD1 . ILE A 1 365 ? -40.256 -5.213 -15.160 1.00 82.77 ? 366 ILE A CD1 1 ATOM 2822 N N . LYS A 1 366 ? -43.760 -4.383 -13.834 0.00 130.49 ? 367 LYS A N 1 ATOM 2823 C CA . LYS A 1 366 ? -45.065 -5.027 -13.702 0.00 135.22 ? 367 LYS A CA 1 ATOM 2824 C C . LYS A 1 366 ? -45.073 -6.448 -13.120 0.00 138.92 ? 367 LYS A C 1 ATOM 2825 O O . LYS A 1 366 ? -44.170 -7.249 -13.346 0.00 140.81 ? 367 LYS A O 1 ATOM 2826 C CB . LYS A 1 366 ? -45.828 -4.961 -15.022 0.00 134.53 ? 367 LYS A CB 1 ATOM 2827 C CG . LYS A 1 366 ? -46.285 -3.558 -15.380 0.00 135.09 ? 367 LYS A CG 1 ATOM 2828 C CD . LYS A 1 366 ? -47.205 -3.559 -16.591 0.00 133.61 ? 367 LYS A CD 1 ATOM 2829 C CE . LYS A 1 366 ? -48.018 -2.273 -16.688 0.00 134.56 ? 367 LYS A CE 1 ATOM 2830 N NZ . LYS A 1 366 ? -47.188 -1.057 -16.916 0.00 134.79 ? 367 LYS A NZ 1 ATOM 2831 N N . PRO A 1 367 ? -47.379 -5.854 -12.938 1.00 136.42 ? 368 PRO A N 1 ATOM 2832 C CA . PRO A 1 367 ? -46.760 -6.783 -12.001 1.00 135.86 ? 368 PRO A CA 1 ATOM 2833 C C . PRO A 1 367 ? -46.086 -7.960 -12.706 1.00 133.91 ? 368 PRO A C 1 ATOM 2834 O O . PRO A 1 367 ? -45.042 -8.432 -12.251 1.00 128.61 ? 368 PRO A O 1 ATOM 2835 C CB . PRO A 1 367 ? -47.950 -7.267 -11.172 1.00 124.13 ? 368 PRO A CB 1 ATOM 2836 C CG . PRO A 1 367 ? -48.915 -6.115 -11.189 1.00 122.70 ? 368 PRO A CG 1 ATOM 2837 C CD . PRO A 1 367 ? -48.594 -5.238 -12.373 1.00 124.22 ? 368 PRO A CD 1 ATOM 2838 N N . ARG A 1 368 ? -46.797 -9.021 -13.879 0.00 145.93 ? 369 ARG A N 1 ATOM 2839 C CA . ARG A 1 368 ? -47.170 -10.115 -14.742 0.00 147.83 ? 369 ARG A CA 1 ATOM 2840 C C . ARG A 1 368 ? -46.180 -11.231 -14.564 0.00 156.34 ? 369 ARG A C 1 ATOM 2841 O O . ARG A 1 368 ? -44.969 -11.070 -14.719 0.00 167.48 ? 369 ARG A O 1 ATOM 2842 C CB . ARG A 1 368 ? -47.195 -9.661 -16.203 0.00 141.50 ? 369 ARG A CB 1 ATOM 2843 C CG . ARG A 1 368 ? -45.861 -9.142 -16.714 0.00 136.80 ? 369 ARG A CG 1 ATOM 2844 C CD . ARG A 1 368 ? -45.958 -8.709 -18.168 0.00 135.97 ? 369 ARG A CD 1 ATOM 2845 N NE . ARG A 1 368 ? -44.684 -8.206 -18.675 0.00 132.40 ? 369 ARG A NE 1 ATOM 2846 C CZ . ARG A 1 368 ? -43.759 -8.965 -19.254 0.00 127.19 ? 369 ARG A CZ 1 ATOM 2847 N NH1 . ARG A 1 368 ? -43.963 -10.266 -19.403 0.00 127.74 ? 369 ARG A NH1 1 ATOM 2848 N NH2 . ARG A 1 368 ? -42.629 -8.422 -19.686 0.00 122.79 ? 369 ARG A NH2 1 ATOM 2849 N N . ILE A 1 369 ? -46.747 -12.381 -14.220 0.00 152.15 ? 370 ILE A N 1 ATOM 2850 C CA . ILE A 1 369 ? -45.969 -13.584 -13.972 0.00 150.12 ? 370 ILE A CA 1 ATOM 2851 C C . ILE A 1 369 ? -44.627 -14.049 -13.440 0.00 146.16 ? 370 ILE A C 1 ATOM 2852 O O . ILE A 1 369 ? -43.594 -13.448 -13.712 0.00 140.90 ? 370 ILE A O 1 ATOM 2853 C CB . ILE A 1 369 ? -46.403 -14.540 -15.102 0.00 149.85 ? 370 ILE A CB 1 ATOM 2854 C CG1 . ILE A 1 369 ? -47.899 -14.406 -15.357 0.00 154.20 ? 370 ILE A CG1 1 ATOM 2855 C CG2 . ILE A 1 369 ? -46.066 -15.985 -14.772 0.00 146.71 ? 370 ILE A CG2 1 ATOM 2856 C CD1 . ILE A 1 369 ? -48.467 -15.496 -16.236 0.00 156.53 ? 370 ILE A CD1 1 ATOM 2857 N N . VAL A 1 370 ? -44.688 -15.139 -12.669 0.00 142.92 ? 371 VAL A N 1 ATOM 2858 C CA . VAL A 1 370 ? -43.549 -15.763 -11.982 0.00 139.40 ? 371 VAL A CA 1 ATOM 2859 C C . VAL A 1 370 ? -42.825 -17.001 -12.572 0.00 135.74 ? 371 VAL A C 1 ATOM 2860 O O . VAL A 1 370 ? -41.746 -17.331 -12.088 0.00 137.41 ? 371 VAL A O 1 ATOM 2861 C CB . VAL A 1 370 ? -43.923 -16.034 -10.491 0.00 139.28 ? 371 VAL A CB 1 ATOM 2862 C CG1 . VAL A 1 370 ? -42.744 -16.574 -9.698 0.00 142.71 ? 371 VAL A CG1 1 ATOM 2863 C CG2 . VAL A 1 370 ? -44.450 -14.768 -9.832 0.00 138.06 ? 371 VAL A CG2 1 ATOM 2864 N N . GLY A 1 371 ? -43.738 -17.430 -13.711 1.00 88.47 ? 372 GLY A N 1 ATOM 2865 C CA . GLY A 1 371 ? -43.327 -18.595 -14.495 1.00 103.63 ? 372 GLY A CA 1 ATOM 2866 C C . GLY A 1 371 ? -42.625 -19.727 -13.753 1.00 105.12 ? 372 GLY A C 1 ATOM 2867 O O . GLY A 1 371 ? -42.954 -20.900 -13.949 1.00 114.30 ? 372 GLY A O 1 ATOM 2868 N N . GLY A 1 372 ? -41.647 -19.381 -12.916 1.00 106.87 ? 373 GLY A N 1 ATOM 2869 C CA . GLY A 1 372 ? -40.829 -20.373 -12.219 1.00 107.32 ? 373 GLY A CA 1 ATOM 2870 C C . GLY A 1 372 ? -39.593 -20.859 -12.973 1.00 113.86 ? 373 GLY A C 1 ATOM 2871 O O . GLY A 1 372 ? -38.570 -21.150 -12.346 1.00 108.56 ? 373 GLY A O 1 ATOM 2872 N N . THR A 1 373 ? -39.676 -20.942 -14.306 1.00 108.83 ? 374 THR A N 1 ATOM 2873 C CA . THR A 1 373 ? -38.575 -21.483 -15.128 1.00 105.47 ? 374 THR A CA 1 ATOM 2874 C C . THR A 1 373 ? -38.326 -20.795 -16.500 1.00 105.82 ? 374 THR A C 1 ATOM 2875 O O . THR A 1 373 ? -37.175 -20.714 -16.964 1.00 96.17 ? 374 THR A O 1 ATOM 2876 C CB . THR A 1 373 ? -38.704 -23.021 -15.287 1.00 106.68 ? 374 THR A CB 1 ATOM 2877 O OG1 . THR A 1 373 ? -37.709 -23.496 -16.208 1.00 104.52 ? 374 THR A OG1 1 ATOM 2878 C CG2 . THR A 1 373 ? -40.137 -23.448 -15.745 1.00 99.55 ? 374 THR A CG2 1 ATOM 2879 N N . ALA A 1 374 ? -39.405 -20.332 -17.137 1.00 112.48 ? 375 ALA A N 1 ATOM 2880 C CA . ALA A 1 374 ? -39.360 -19.677 -18.462 1.00 106.62 ? 375 ALA A CA 1 ATOM 2881 C C . ALA A 1 374 ? -40.002 -18.283 -18.451 1.00 100.26 ? 375 ALA A C 1 ATOM 2882 O O . ALA A 1 374 ? -40.830 -17.964 -17.580 1.00 95.40 ? 375 ALA A O 1 ATOM 2883 C CB . ALA A 1 374 ? -40.025 -20.557 -19.513 1.00 109.45 ? 375 ALA A CB 1 ATOM 2884 N N . SER A 1 375 ? -39.633 -17.467 -19.434 1.00 89.52 ? 376 SER A N 1 ATOM 2885 C CA . SER A 1 375 ? -39.965 -16.033 -19.420 1.00 97.35 ? 376 SER A CA 1 ATOM 2886 C C . SER A 1 375 ? -41.265 -15.673 -20.182 1.00 97.81 ? 376 SER A C 1 ATOM 2887 O O . SER A 1 375 ? -41.940 -16.594 -20.624 1.00 112.15 ? 376 SER A O 1 ATOM 2888 C CB . SER A 1 375 ? -38.743 -15.244 -19.885 1.00 98.34 ? 376 SER A CB 1 ATOM 2889 O OG . SER A 1 375 ? -37.602 -15.716 -19.184 1.00 93.26 ? 376 SER A OG 1 ATOM 2890 N N . VAL A 1 376 ? -41.643 -14.383 -20.294 1.00 91.08 ? 377 VAL A N 1 ATOM 2891 C CA . VAL A 1 376 ? -42.842 -13.962 -21.099 1.00 92.39 ? 377 VAL A CA 1 ATOM 2892 C C . VAL A 1 376 ? -42.975 -12.437 -21.387 1.00 92.66 ? 377 VAL A C 1 ATOM 2893 O O . VAL A 1 376 ? -42.272 -11.617 -20.777 1.00 88.30 ? 377 VAL A O 1 ATOM 2894 C CB . VAL A 1 376 ? -44.193 -14.627 -20.608 1.00 95.64 ? 377 VAL A CB 1 ATOM 2895 C CG1 . VAL A 1 376 ? -44.897 -13.803 -19.524 1.00 91.91 ? 377 VAL A CG1 1 ATOM 2896 C CG2 . VAL A 1 376 ? -45.132 -14.973 -21.783 1.00 86.46 ? 377 VAL A CG2 1 ATOM 2897 N N . ARG A 1 377 ? -43.865 -12.101 -22.335 1.00 89.92 ? 378 ARG A N 1 ATOM 2898 C CA . ARG A 1 377 ? -44.168 -10.738 -22.771 1.00 73.82 ? 378 ARG A CA 1 ATOM 2899 C C . ARG A 1 377 ? -42.912 -9.718 -22.195 0.00 102.43 ? 378 ARG A C 1 ATOM 2900 O O . ARG A 1 377 ? -42.238 -9.085 -22.991 0.00 101.98 ? 378 ARG A O 1 ATOM 2901 C CB . ARG A 1 377 ? -45.104 -10.518 -22.972 0.00 103.65 ? 378 ARG A CB 1 ATOM 2902 C CG . ARG A 1 377 ? -45.870 -9.998 -21.763 0.00 104.80 ? 378 ARG A CG 1 ATOM 2903 C CD . ARG A 1 377 ? -47.295 -9.614 -22.141 0.00 106.32 ? 378 ARG A CD 1 ATOM 2904 N NE . ARG A 1 377 ? -47.944 -8.754 -21.151 0.00 114.00 ? 378 ARG A NE 1 ATOM 2905 C CZ . ARG A 1 377 ? -48.545 -9.199 -20.054 0.00 118.78 ? 378 ARG A CZ 1 ATOM 2906 N NH1 . ARG A 1 377 ? -48.565 -10.497 -19.794 0.00 120.79 ? 378 ARG A NH1 1 ATOM 2907 N NH2 . ARG A 1 377 ? -49.120 -8.350 -19.216 0.00 129.36 ? 378 ARG A NH2 1 ATOM 2908 N N . GLY A 1 378 ? -42.904 -9.155 -21.551 1.00 67.45 ? 379 GLY A N 1 ATOM 2909 C CA . GLY A 1 378 ? -42.237 -8.004 -20.949 1.00 89.08 ? 379 GLY A CA 1 ATOM 2910 C C . GLY A 1 378 ? -41.518 -8.251 -19.622 1.00 91.83 ? 379 GLY A C 1 ATOM 2911 O O . GLY A 1 378 ? -41.367 -7.319 -18.811 1.00 93.77 ? 379 GLY A O 1 ATOM 2912 N N . GLU A 1 379 ? -41.056 -9.487 -19.407 1.00 84.38 ? 380 GLU A N 1 ATOM 2913 C CA . GLU A 1 379 ? -40.401 -9.862 -18.155 1.00 81.02 ? 380 GLU A CA 1 ATOM 2914 C C . GLU A 1 379 ? -39.009 -9.264 -17.982 1.00 88.92 ? 380 GLU A C 1 ATOM 2915 O O . GLU A 1 379 ? -38.633 -8.862 -16.886 1.00 88.64 ? 380 GLU A O 1 ATOM 2916 C CB . GLU A 1 379 ? -40.302 -11.364 -18.059 1.00 79.39 ? 380 GLU A CB 1 ATOM 2917 C CG . GLU A 1 379 ? -40.124 -11.846 -16.634 1.00 85.40 ? 380 GLU A CG 1 ATOM 2918 C CD . GLU A 1 379 ? -40.061 -13.353 -16.561 1.00 94.20 ? 380 GLU A CD 1 ATOM 2919 O OE1 . GLU A 1 379 ? -39.582 -13.899 -15.547 1.00 96.12 ? 380 GLU A OE1 1 ATOM 2920 O OE2 . GLU A 1 379 ? -40.492 -13.994 -17.532 1.00 98.06 ? 380 GLU A OE2 1 ATOM 2921 N N . TRP A 1 380 ? -38.245 -9.221 -19.069 1.00 95.81 ? 381 TRP A N 1 ATOM 2922 C CA . TRP A 1 380 ? -36.868 -8.746 -19.044 1.00 85.01 ? 381 TRP A CA 1 ATOM 2923 C C . TRP A 1 380 ? -36.650 -7.740 -20.163 1.00 84.07 ? 381 TRP A C 1 ATOM 2924 O O . TRP A 1 380 ? -35.818 -7.966 -21.039 1.00 82.70 ? 381 TRP A O 1 ATOM 2925 C CB . TRP A 1 380 ? -35.929 -9.919 -19.238 1.00 81.66 ? 381 TRP A CB 1 ATOM 2926 C CG . TRP A 1 380 ? -36.270 -11.084 -18.410 1.00 84.91 ? 381 TRP A CG 1 ATOM 2927 C CD1 . TRP A 1 380 ? -36.928 -12.208 -18.811 1.00 90.50 ? 381 TRP A CD1 1 ATOM 2928 C CD2 . TRP A 1 380 ? -35.985 -11.255 -17.022 1.00 83.66 ? 381 TRP A CD2 1 ATOM 2929 N NE1 . TRP A 1 380 ? -37.055 -13.086 -17.756 1.00 90.51 ? 381 TRP A NE1 1 ATOM 2930 C CE2 . TRP A 1 380 ? -36.479 -12.527 -16.648 1.00 81.73 ? 381 TRP A CE2 1 ATOM 2931 C CE3 . TRP A 1 380 ? -35.348 -10.461 -16.055 1.00 81.94 ? 381 TRP A CE3 1 ATOM 2932 C CZ2 . TRP A 1 380 ? -36.359 -13.023 -15.357 1.00 81.38 ? 381 TRP A CZ2 1 ATOM 2933 C CZ3 . TRP A 1 380 ? -35.233 -10.949 -14.766 1.00 80.27 ? 381 TRP A CZ3 1 ATOM 2934 C CH2 . TRP A 1 380 ? -35.739 -12.219 -14.427 1.00 86.12 ? 381 TRP A CH2 1 ATOM 2935 N N . PRO A 1 381 ? -37.381 -6.612 -20.131 1.00 79.54 ? 382 PRO A N 1 ATOM 2936 C CA . PRO A 1 381 ? -37.369 -5.620 -21.214 1.00 80.74 ? 382 PRO A CA 1 ATOM 2937 C C . PRO A 1 381 ? -35.993 -5.051 -21.636 1.00 82.20 ? 382 PRO A C 1 ATOM 2938 O O . PRO A 1 381 ? -35.927 -4.338 -22.650 1.00 82.97 ? 382 PRO A O 1 ATOM 2939 C CB . PRO A 1 381 ? -38.214 -4.490 -20.637 1.00 84.99 ? 382 PRO A CB 1 ATOM 2940 C CG . PRO A 1 381 ? -38.032 -4.628 -19.161 1.00 87.16 ? 382 PRO A CG 1 ATOM 2941 C CD . PRO A 1 381 ? -38.113 -6.104 -18.959 1.00 74.71 ? 382 PRO A CD 1 ATOM 2942 N N . TRP A 1 382 ? -34.928 -5.336 -20.875 1.00 75.77 ? 383 TRP A N 1 ATOM 2943 C CA . TRP A 1 382 ? -33.581 -4.837 -21.209 1.00 76.08 ? 383 TRP A CA 1 ATOM 2944 C C . TRP A 1 382 ? -32.710 -5.824 -21.994 1.00 79.48 ? 383 TRP A C 1 ATOM 2945 O O . TRP A 1 382 ? -31.835 -5.407 -22.760 1.00 74.19 ? 383 TRP A O 1 ATOM 2946 C CB . TRP A 1 382 ? -32.842 -4.364 -19.965 1.00 73.46 ? 383 TRP A CB 1 ATOM 2947 C CG . TRP A 1 382 ? -32.649 -5.422 -18.957 1.00 75.58 ? 383 TRP A CG 1 ATOM 2948 C CD1 . TRP A 1 382 ? -31.644 -6.347 -18.914 1.00 75.08 ? 383 TRP A CD1 1 ATOM 2949 C CD2 . TRP A 1 382 ? -33.475 -5.669 -17.820 1.00 79.73 ? 383 TRP A CD2 1 ATOM 2950 N NE1 . TRP A 1 382 ? -31.797 -7.166 -17.817 1.00 72.86 ? 383 TRP A NE1 1 ATOM 2951 C CE2 . TRP A 1 382 ? -32.913 -6.774 -17.127 1.00 76.53 ? 383 TRP A CE2 1 ATOM 2952 C CE3 . TRP A 1 382 ? -34.637 -5.061 -17.308 1.00 74.75 ? 383 TRP A CE3 1 ATOM 2953 C CZ2 . TRP A 1 382 ? -33.475 -7.288 -15.948 1.00 73.10 ? 383 TRP A CZ2 1 ATOM 2954 C CZ3 . TRP A 1 382 ? -35.195 -5.570 -16.142 1.00 70.33 ? 383 TRP A CZ3 1 ATOM 2955 C CH2 . TRP A 1 382 ? -34.611 -6.675 -15.471 1.00 70.16 ? 383 TRP A CH2 1 ATOM 2956 N N . GLN A 1 383 ? -32.959 -7.119 -21.771 1.00 79.02 ? 384 GLN A N 1 ATOM 2957 C CA . GLN A 1 383 ? -32.292 -8.233 -22.444 1.00 70.86 ? 384 GLN A CA 1 ATOM 2958 C C . GLN A 1 383 ? -32.551 -8.208 -23.941 1.00 74.63 ? 384 GLN A C 1 ATOM 2959 O O . GLN A 1 383 ? -33.700 -8.102 -24.381 1.00 76.08 ? 384 GLN A O 1 ATOM 2960 C CB . GLN A 1 383 ? -32.783 -9.554 -21.853 1.00 72.14 ? 384 GLN A CB 1 ATOM 2961 C CG . GLN A 1 383 ? -32.449 -10.787 -22.666 1.00 77.57 ? 384 GLN A CG 1 ATOM 2962 C CD . GLN A 1 383 ? -31.016 -11.224 -22.489 1.00 83.62 ? 384 GLN A CD 1 ATOM 2963 O OE1 . GLN A 1 383 ? -30.680 -11.871 -21.499 1.00 86.31 ? 384 GLN A OE1 1 ATOM 2964 N NE2 . GLN A 1 383 ? -30.163 -10.888 -23.456 1.00 87.35 ? 384 GLN A NE2 1 ATOM 2965 N N . VAL A 1 384 ? -31.465 -8.286 -24.715 1.00 80.39 ? 385 VAL A N 1 ATOM 2966 C CA . VAL A 1 384 ? -31.528 -8.325 -26.191 1.00 67.26 ? 385 VAL A CA 1 ATOM 2967 C C . VAL A 1 384 ? -30.754 -9.521 -26.714 1.00 62.25 ? 385 VAL A C 1 ATOM 2968 O O . VAL A 1 384 ? -29.857 -10.040 -26.038 1.00 57.44 ? 385 VAL A O 1 ATOM 2969 C CB . VAL A 1 384 ? -31.057 -7.006 -26.886 1.00 59.63 ? 385 VAL A CB 1 ATOM 2970 C CG1 . VAL A 1 384 ? -32.047 -5.872 -26.659 1.00 51.48 ? 385 VAL A CG1 1 ATOM 2971 C CG2 . VAL A 1 384 ? -29.652 -6.598 -26.464 1.00 56.36 ? 385 VAL A CG2 1 ATOM 2972 N N . THR A 1 385 ? -31.143 -9.953 -27.908 1.00 65.15 ? 386 THR A N 1 ATOM 2973 C CA . THR A 1 385 ? -30.456 -11.013 -28.653 1.00 72.07 ? 386 THR A CA 1 ATOM 2974 C C . THR A 1 385 ? -29.653 -10.388 -29.806 1.00 74.46 ? 386 THR A C 1 ATOM 2975 O O . THR A 1 385 ? -30.138 -9.486 -30.496 1.00 79.19 ? 386 THR A O 1 ATOM 2976 C CB . THR A 1 385 ? -31.433 -12.121 -29.140 1.00 73.50 ? 386 THR A CB 1 ATOM 2977 O OG1 . THR A 1 385 ? -30.764 -12.993 -30.053 1.00 73.66 ? 386 THR A OG1 1 ATOM 2978 C CG2 . THR A 1 385 ? -32.697 -11.546 -29.828 1.00 71.39 ? 386 THR A CG2 1 ATOM 2979 N N . LEU A 1 386 ? -28.419 -10.856 -29.981 1.00 75.87 ? 387 LEU A N 1 ATOM 2980 C CA . LEU A 1 386 ? -27.470 -10.244 -30.908 1.00 69.35 ? 387 LEU A CA 1 ATOM 2981 C C . LEU A 1 386 ? -27.161 -11.156 -32.067 1.00 70.74 ? 387 LEU A C 1 ATOM 2982 O O . LEU A 1 386 ? -26.525 -12.191 -31.915 1.00 79.11 ? 387 LEU A O 1 ATOM 2983 C CB . LEU A 1 386 ? -26.188 -9.883 -30.192 1.00 69.94 ? 387 LEU A CB 1 ATOM 2984 C CG . LEU A 1 386 ? -25.685 -8.534 -30.644 1.00 82.35 ? 387 LEU A CG 1 ATOM 2985 C CD1 . LEU A 1 386 ? -26.595 -7.475 -30.047 1.00 88.33 ? 387 LEU A CD1 1 ATOM 2986 C CD2 . LEU A 1 386 ? -24.252 -8.341 -30.179 1.00 93.12 ? 387 LEU A CD2 1 ATOM 2987 N N . HIS A 1 387 ? -27.621 -10.767 -33.237 1.00 68.45 ? 388 HIS A N 1 ATOM 2988 C CA . HIS A 1 387 ? -27.521 -11.628 -34.370 1.00 62.07 ? 388 HIS A CA 1 ATOM 2989 C C . HIS A 1 387 ? -26.388 -11.273 -35.287 1.00 68.92 ? 388 HIS A C 1 ATOM 2990 O O . HIS A 1 387 ? -26.017 -10.101 -35.472 1.00 69.22 ? 388 HIS A O 1 ATOM 2991 C CB . HIS A 1 387 ? -28.852 -11.716 -35.084 1.00 59.22 ? 388 HIS A CB 1 ATOM 2992 C CG . HIS A 1 387 ? -29.755 -12.748 -34.492 1.00 68.76 ? 388 HIS A CG 1 ATOM 2993 N ND1 . HIS A 1 387 ? -30.502 -13.618 -35.258 1.00 71.16 ? 388 HIS A ND1 1 ATOM 2994 C CD2 . HIS A 1 387 ? -30.002 -13.078 -33.200 1.00 70.60 ? 388 HIS A CD2 1 ATOM 2995 C CE1 . HIS A 1 387 ? -31.186 -14.425 -34.466 1.00 71.60 ? 388 HIS A CE1 1 ATOM 2996 N NE2 . HIS A 1 387 ? -30.902 -14.118 -33.212 1.00 75.50 ? 388 HIS A NE2 1 ATOM 2997 N N . THR A 1 388 ? -25.808 -12.320 -35.840 1.00 74.98 ? 389 THR A N 1 ATOM 2998 C CA . THR A 1 388 ? -24.800 -12.151 -36.855 1.00 75.25 ? 389 THR A CA 1 ATOM 2999 C C . THR A 1 388 ? -25.314 -12.661 -38.202 1.00 80.68 ? 389 THR A C 1 ATOM 3000 O O . THR A 1 388 ? -26.079 -13.629 -38.254 1.00 85.86 ? 389 THR A O 1 ATOM 3001 C CB . THR A 1 388 ? -23.481 -12.779 -36.416 1.00 67.11 ? 389 THR A CB 1 ATOM 3002 O OG1 . THR A 1 388 ? -22.460 -12.346 -37.306 1.00 74.89 ? 389 THR A OG1 1 ATOM 3003 C CG2 . THR A 1 388 ? -23.555 -14.287 -36.400 1.00 68.26 ? 389 THR A CG2 1 ATOM 3004 N N . THR A 1 389 ? -24.937 -11.985 -39.282 1.00 80.18 ? 390 THR A N 1 ATOM 3005 C CA . THR A 1 389 ? -25.447 -12.365 -40.597 1.00 79.93 ? 390 THR A CA 1 ATOM 3006 C C . THR A 1 389 ? -24.531 -13.358 -41.318 1.00 86.52 ? 390 THR A C 1 ATOM 3007 O O . THR A 1 389 ? -24.959 -13.988 -42.295 1.00 97.89 ? 390 THR A O 1 ATOM 3008 C CB . THR A 1 389 ? -25.805 -11.144 -41.462 1.00 76.91 ? 390 THR A CB 1 ATOM 3009 O OG1 . THR A 1 389 ? -24.779 -10.158 -41.350 1.00 73.52 ? 390 THR A OG1 1 ATOM 3010 C CG2 . THR A 1 389 ? -27.118 -10.541 -40.976 1.00 74.10 ? 390 THR A CG2 1 ATOM 3011 N N . SER A 1 390 ? -23.296 -13.494 -40.812 1.00 80.26 ? 391 SER A N 1 ATOM 3012 C CA . SER A 1 390 ? -22.306 -14.474 -41.276 1.00 70.34 ? 391 SER A CA 1 ATOM 3013 C C . SER A 1 390 ? -22.096 -15.630 -40.280 1.00 72.00 ? 391 SER A C 1 ATOM 3014 O O . SER A 1 390 ? -22.003 -15.380 -39.080 1.00 66.93 ? 391 SER A O 1 ATOM 3015 C CB . SER A 1 390 ? -20.972 -13.796 -41.499 1.00 65.32 ? 391 SER A CB 1 ATOM 3016 O OG . SER A 1 390 ? -19.910 -14.695 -41.206 1.00 69.44 ? 391 SER A OG 1 ATOM 3017 N N . PRO A 1 391 ? -21.968 -16.879 -40.751 1.00 71.04 ? 392 PRO A N 1 ATOM 3018 C CA . PRO A 1 391 ? -22.003 -17.244 -42.168 1.00 71.18 ? 392 PRO A CA 1 ATOM 3019 C C . PRO A 1 391 ? -23.414 -17.194 -42.716 1.00 77.23 ? 392 PRO A C 1 ATOM 3020 O O . PRO A 1 391 ? -23.618 -16.860 -43.892 1.00 78.89 ? 392 PRO A O 1 ATOM 3021 C CB . PRO A 1 391 ? -21.474 -18.677 -42.163 1.00 68.54 ? 392 PRO A CB 1 ATOM 3022 C CG . PRO A 1 391 ? -20.562 -18.712 -40.994 1.00 69.88 ? 392 PRO A CG 1 ATOM 3023 C CD . PRO A 1 391 ? -21.270 -17.901 -39.951 1.00 69.55 ? 392 PRO A CD 1 ATOM 3024 N N . THR A 1 392 ? -24.367 -17.557 -41.859 1.00 82.31 ? 393 THR A N 1 ATOM 3025 C CA . THR A 1 392 ? -25.783 -17.230 -42.037 1.00 85.24 ? 393 THR A CA 1 ATOM 3026 C C . THR A 1 392 ? -26.263 -16.595 -40.726 1.00 85.25 ? 393 THR A C 1 ATOM 3027 O O . THR A 1 392 ? -25.496 -16.554 -39.746 1.00 79.45 ? 393 THR A O 1 ATOM 3028 C CB . THR A 1 392 ? -26.647 -18.458 -42.431 1.00 81.02 ? 393 THR A CB 1 ATOM 3029 O OG1 . THR A 1 392 ? -26.872 -19.293 -41.289 1.00 83.11 ? 393 THR A OG1 1 ATOM 3030 C CG2 . THR A 1 392 ? -25.993 -19.262 -43.563 1.00 74.56 ? 393 THR A CG2 1 ATOM 3031 N N . GLN A 1 393 ? -27.512 -16.111 -40.706 1.00 88.65 ? 394 GLN A N 1 ATOM 3032 C CA . GLN A 1 393 ? -28.060 -15.450 -39.513 1.00 78.13 ? 394 GLN A CA 1 ATOM 3033 C C . GLN A 1 393 ? -28.337 -16.348 -38.328 1.00 75.19 ? 394 GLN A C 1 ATOM 3034 O O . GLN A 1 393 ? -29.172 -17.250 -38.378 1.00 71.67 ? 394 GLN A O 1 ATOM 3035 C CB . GLN A 1 393 ? -29.280 -14.595 -39.803 1.00 74.36 ? 394 GLN A CB 1 ATOM 3036 C CG . GLN A 1 393 ? -29.569 -13.664 -38.640 1.00 75.32 ? 394 GLN A CG 1 ATOM 3037 C CD . GLN A 1 393 ? -30.853 -12.896 -38.813 1.00 76.70 ? 394 GLN A CD 1 ATOM 3038 O OE1 . GLN A 1 393 ? -30.868 -11.838 -39.439 1.00 75.38 ? 394 GLN A OE1 1 ATOM 3039 N NE2 . GLN A 1 393 ? -31.937 -13.417 -38.248 1.00 69.61 ? 394 GLN A NE2 1 ATOM 3040 N N . ARG A 1 394 ? -27.621 -16.052 -37.253 1.00 80.10 ? 395 ARG A N 1 ATOM 3041 C CA . ARG A 1 394 ? -27.717 -16.775 -35.998 1.00 82.44 ? 395 ARG A CA 1 ATOM 3042 C C . ARG A 1 394 ? -27.575 -15.816 -34.804 1.00 79.74 ? 395 ARG A C 1 ATOM 3043 O O . ARG A 1 394 ? -26.971 -14.736 -34.907 1.00 72.39 ? 395 ARG A O 1 ATOM 3044 C CB . ARG A 1 394 ? -26.646 -17.881 -35.948 1.00 88.52 ? 395 ARG A CB 1 ATOM 3045 C CG . ARG A 1 394 ? -25.202 -17.373 -35.879 1.00 97.80 ? 395 ARG A CG 1 ATOM 3046 C CD . ARG A 1 394 ? -24.253 -18.166 -36.752 1.00 97.45 ? 395 ARG A CD 1 ATOM 3047 N NE . ARG A 1 394 ? -24.377 -19.578 -36.430 1.00 107.38 ? 395 ARG A NE 1 ATOM 3048 C CZ . ARG A 1 394 ? -23.653 -20.548 -36.969 1.00 115.21 ? 395 ARG A CZ 1 ATOM 3049 N NH1 . ARG A 1 394 ? -22.721 -20.268 -37.877 1.00 121.60 ? 395 ARG A NH1 1 ATOM 3050 N NH2 . ARG A 1 394 ? -23.862 -21.804 -36.583 1.00 108.17 ? 395 ARG A NH2 1 ATOM 3051 N N . HIS A 1 395 ? -28.156 -16.223 -33.681 1.00 77.94 ? 396 HIS A N 1 ATOM 3052 C CA . HIS A 1 395 ? -27.806 -15.663 -32.392 1.00 77.41 ? 396 HIS A CA 1 ATOM 3053 C C . HIS A 1 395 ? -26.280 -15.770 -32.133 1.00 76.76 ? 396 HIS A C 1 ATOM 3054 O O . HIS A 1 395 ? -25.649 -16.806 -32.384 1.00 68.64 ? 396 HIS A O 1 ATOM 3055 C CB . HIS A 1 395 ? -28.610 -16.357 -31.289 1.00 79.66 ? 396 HIS A CB 1 ATOM 3056 C CG . HIS A 1 395 ? -28.361 -15.795 -29.929 1.00 85.62 ? 396 HIS A CG 1 ATOM 3057 N ND1 . HIS A 1 395 ? -27.646 -16.471 -28.964 1.00 94.83 ? 396 HIS A ND1 1 ATOM 3058 C CD2 . HIS A 1 395 ? -28.685 -14.597 -29.389 1.00 82.30 ? 396 HIS A CD2 1 ATOM 3059 C CE1 . HIS A 1 395 ? -27.556 -15.717 -27.882 1.00 91.77 ? 396 HIS A CE1 1 ATOM 3060 N NE2 . HIS A 1 395 ? -28.181 -14.577 -28.114 1.00 83.46 ? 396 HIS A NE2 1 ATOM 3061 N N . LEU A 1 396 ? -25.705 -14.671 -31.657 1.00 75.54 ? 397 LEU A N 1 ATOM 3062 C CA . LEU A 1 396 ? -24.300 -14.603 -31.284 1.00 71.60 ? 397 LEU A CA 1 ATOM 3063 C C . LEU A 1 396 ? -24.127 -14.295 -29.766 1.00 79.22 ? 397 LEU A C 1 ATOM 3064 O O . LEU A 1 396 ? -23.490 -15.068 -29.039 1.00 85.55 ? 397 LEU A O 1 ATOM 3065 C CB . LEU A 1 396 ? -23.579 -13.601 -32.205 1.00 61.60 ? 397 LEU A CB 1 ATOM 3066 C CG . LEU A 1 396 ? -22.159 -13.071 -31.937 1.00 62.08 ? 397 LEU A CG 1 ATOM 3067 C CD1 . LEU A 1 396 ? -21.114 -14.183 -31.898 1.00 63.47 ? 397 LEU A CD1 1 ATOM 3068 C CD2 . LEU A 1 396 ? -21.762 -11.995 -32.942 1.00 53.36 ? 397 LEU A CD2 1 ATOM 3069 N N . CYS A 1 397 ? -24.714 -13.192 -29.293 1.00 80.94 ? 398 CYS A N 1 ATOM 3070 C CA . CYS A 1 397 ? -24.607 -12.778 -27.892 1.00 74.92 ? 398 CYS A CA 1 ATOM 3071 C C . CYS A 1 397 ? -25.922 -12.351 -27.249 1.00 73.48 ? 398 CYS A C 1 ATOM 3072 O O . CYS A 1 397 ? -26.923 -12.139 -27.931 1.00 74.05 ? 398 CYS A O 1 ATOM 3073 C CB . CYS A 1 397 ? -23.568 -11.672 -27.764 1.00 79.37 ? 398 CYS A CB 1 ATOM 3074 S SG . CYS A 1 397 ? -21.945 -12.433 -27.860 1.00 108.10 ? 398 CYS A SG 1 ATOM 3075 N N . GLY A 1 398 ? -25.918 -12.293 -25.919 1.00 71.64 ? 399 GLY A N 1 ATOM 3076 C CA . GLY A 1 398 ? -26.941 -11.582 -25.152 1.00 66.78 ? 399 GLY A CA 1 ATOM 3077 C C . GLY A 1 398 ? -26.412 -10.179 -24.895 1.00 64.76 ? 399 GLY A C 1 ATOM 3078 O O . GLY A 1 398 ? -25.201 -9.960 -24.861 1.00 63.55 ? 399 GLY A O 1 ATOM 3079 N N . GLY A 1 399 ? -27.304 -9.212 -24.745 1.00 61.00 ? 400 GLY A N 1 ATOM 3080 C CA . GLY A 1 399 ? -26.872 -7.866 -24.396 1.00 64.94 ? 400 GLY A CA 1 ATOM 3081 C C . GLY A 1 399 ? -27.924 -7.249 -23.520 1.00 65.72 ? 400 GLY A C 1 ATOM 3082 O O . GLY A 1 399 ? -29.035 -7.782 -23.430 1.00 67.40 ? 400 GLY A O 1 ATOM 3083 N N . SER A 1 400 ? -27.599 -6.132 -22.882 1.00 59.61 ? 401 SER A N 1 ATOM 3084 C CA . SER A 1 400 ? -28.623 -5.424 -22.135 1.00 59.31 ? 401 SER A CA 1 ATOM 3085 C C . SER A 1 400 ? -28.749 -3.998 -22.630 1.00 56.14 ? 401 SER A C 1 ATOM 3086 O O . SER A 1 400 ? -27.719 -3.321 -22.847 1.00 52.21 ? 401 SER A O 1 ATOM 3087 C CB . SER A 1 400 ? -28.316 -5.442 -20.642 1.00 66.96 ? 401 SER A CB 1 ATOM 3088 O OG . SER A 1 400 ? -27.575 -6.597 -20.304 1.00 80.64 ? 401 SER A OG 1 ATOM 3089 N N . ILE A 1 401 ? -30.006 -3.555 -22.798 1.00 51.49 ? 402 ILE A N 1 ATOM 3090 C CA . ILE A 1 401 ? -30.340 -2.150 -23.129 1.00 51.70 ? 402 ILE A CA 1 ATOM 3091 C C . ILE A 1 401 ? -29.986 -1.281 -21.932 1.00 51.17 ? 402 ILE A C 1 ATOM 3092 O O . ILE A 1 401 ? -30.476 -1.521 -20.837 1.00 51.51 ? 402 ILE A O 1 ATOM 3093 C CB . ILE A 1 401 ? -31.841 -1.922 -23.497 1.00 51.00 ? 402 ILE A CB 1 ATOM 3094 C CG1 . ILE A 1 401 ? -32.256 -2.706 -24.754 1.00 55.27 ? 402 ILE A CG1 1 ATOM 3095 C CG2 . ILE A 1 401 ? -32.085 -0.455 -23.802 1.00 48.52 ? 402 ILE A CG2 1 ATOM 3096 C CD1 . ILE A 1 401 ? -33.750 -2.925 -24.958 1.00 54.34 ? 402 ILE A CD1 1 ATOM 3097 N N . ILE A 1 402 ? -29.128 -0.288 -22.118 1.00 50.36 ? 403 ILE A N 1 ATOM 3098 C CA . ILE A 1 402 ? -28.796 0.567 -20.984 1.00 55.11 ? 403 ILE A CA 1 ATOM 3099 C C . ILE A 1 402 ? -28.988 2.032 -21.305 1.00 62.41 ? 403 ILE A C 1 ATOM 3100 O O . ILE A 1 402 ? -28.732 2.898 -20.465 1.00 69.78 ? 403 ILE A O 1 ATOM 3101 C CB . ILE A 1 402 ? -27.377 0.301 -20.434 1.00 50.34 ? 403 ILE A CB 1 ATOM 3102 C CG1 . ILE A 1 402 ? -26.294 0.700 -21.457 1.00 44.92 ? 403 ILE A CG1 1 ATOM 3103 C CG2 . ILE A 1 402 ? -27.267 -1.138 -19.957 1.00 49.10 ? 403 ILE A CG2 1 ATOM 3104 C CD1 . ILE A 1 402 ? -24.964 1.057 -20.822 1.00 40.03 ? 403 ILE A CD1 1 ATOM 3105 N N . GLY A 1 403 ? -29.429 2.293 -22.529 1.00 67.81 ? 404 GLY A N 1 ATOM 3106 C CA . GLY A 1 403 ? -29.575 3.644 -23.061 1.00 74.73 ? 404 GLY A CA 1 ATOM 3107 C C . GLY A 1 403 ? -30.613 3.640 -24.164 1.00 86.62 ? 404 GLY A C 1 ATOM 3108 O O . GLY A 1 403 ? -31.124 2.581 -24.562 1.00 78.00 ? 404 GLY A O 1 ATOM 3109 N N . ASN A 1 404 ? -30.947 4.827 -24.656 1.00 96.62 ? 405 ASN A N 1 ATOM 3110 C CA . ASN A 1 404 ? -31.834 4.932 -25.804 1.00 99.58 ? 405 ASN A CA 1 ATOM 3111 C C . ASN A 1 404 ? -31.196 4.283 -27.013 1.00 92.13 ? 405 ASN A C 1 ATOM 3112 O O . ASN A 1 404 ? -31.874 3.652 -27.818 1.00 78.50 ? 405 ASN A O 1 ATOM 3113 C CB . ASN A 1 404 ? -32.123 6.398 -26.109 1.00 107.56 ? 405 ASN A CB 1 ATOM 3114 C CG . ASN A 1 404 ? -33.362 6.894 -25.419 1.00 114.99 ? 405 ASN A CG 1 ATOM 3115 O OD1 . ASN A 1 404 ? -34.400 6.232 -25.434 1.00 123.85 ? 405 ASN A OD1 1 ATOM 3116 N ND2 . ASN A 1 404 ? -33.270 8.071 -24.815 1.00 122.14 ? 405 ASN A ND2 1 ATOM 3117 N N . GLN A 1 405 ? -29.870 4.417 -27.067 1.00 91.25 ? 406 GLN A N 1 ATOM 3118 C CA . GLN A 1 405 ? -29.069 4.209 -28.251 1.00 86.23 ? 406 GLN A CA 1 ATOM 3119 C C . GLN A 1 405 ? -27.944 3.184 -28.019 1.00 85.35 ? 406 GLN A C 1 ATOM 3120 O O . GLN A 1 405 ? -27.124 2.945 -28.922 1.00 81.92 ? 406 GLN A O 1 ATOM 3121 C CB . GLN A 1 405 ? -28.485 5.561 -28.659 1.00 80.60 ? 406 GLN A CB 1 ATOM 3122 C CG . GLN A 1 405 ? -28.364 5.714 -30.159 1.00 94.29 ? 406 GLN A CG 1 ATOM 3123 C CD . GLN A 1 405 ? -27.857 7.075 -30.581 1.00 96.04 ? 406 GLN A CD 1 ATOM 3124 O OE1 . GLN A 1 405 ? -28.490 8.092 -30.303 1.00 95.76 ? 406 GLN A OE1 1 ATOM 3125 N NE2 . GLN A 1 405 ? -26.720 7.099 -31.282 1.00 88.95 ? 406 GLN A NE2 1 ATOM 3126 N N . TRP A 1 406 ? -27.930 2.565 -26.829 1.00 75.28 ? 407 TRP A N 1 ATOM 3127 C CA . TRP A 1 406 ? -26.787 1.772 -26.360 1.00 68.45 ? 407 TRP A CA 1 ATOM 3128 C C . TRP A 1 406 ? -27.060 0.376 -25.824 1.00 66.19 ? 407 TRP A C 1 ATOM 3129 O O . TRP A 1 406 ? -28.036 0.167 -25.101 1.00 75.20 ? 407 TRP A O 1 ATOM 3130 C CB . TRP A 1 406 ? -26.075 2.520 -25.263 1.00 67.94 ? 407 TRP A CB 1 ATOM 3131 C CG . TRP A 1 406 ? -25.428 3.752 -25.713 1.00 71.60 ? 407 TRP A CG 1 ATOM 3132 C CD1 . TRP A 1 406 ? -25.913 4.999 -25.576 1.00 73.35 ? 407 TRP A CD1 1 ATOM 3133 C CD2 . TRP A 1 406 ? -24.157 3.878 -26.361 1.00 71.89 ? 407 TRP A CD2 1 ATOM 3134 N NE1 . TRP A 1 406 ? -25.024 5.910 -26.075 1.00 79.61 ? 407 TRP A NE1 1 ATOM 3135 C CE2 . TRP A 1 406 ? -23.938 5.249 -26.576 1.00 73.71 ? 407 TRP A CE2 1 ATOM 3136 C CE3 . TRP A 1 406 ? -23.174 2.966 -26.765 1.00 79.30 ? 407 TRP A CE3 1 ATOM 3137 C CZ2 . TRP A 1 406 ? -22.774 5.747 -27.175 1.00 70.40 ? 407 TRP A CZ2 1 ATOM 3138 C CZ3 . TRP A 1 406 ? -22.014 3.460 -27.369 1.00 77.79 ? 407 TRP A CZ3 1 ATOM 3139 C CH2 . TRP A 1 406 ? -21.833 4.840 -27.568 1.00 72.75 ? 407 TRP A CH2 1 ATOM 3140 N N . ILE A 1 407 ? -26.158 -0.558 -26.146 1.00 57.78 ? 408 ILE A N 1 ATOM 3141 C CA . ILE A 1 407 ? -26.142 -1.897 -25.549 1.00 50.59 ? 408 ILE A CA 1 ATOM 3142 C C . ILE A 1 407 ? -24.822 -2.129 -24.855 1.00 51.95 ? 408 ILE A C 1 ATOM 3143 O O . ILE A 1 407 ? -23.775 -1.821 -25.389 1.00 60.46 ? 408 ILE A O 1 ATOM 3144 C CB . ILE A 1 407 ? -26.312 -3.045 -26.575 1.00 47.14 ? 408 ILE A CB 1 ATOM 3145 C CG1 . ILE A 1 407 ? -27.514 -2.846 -27.539 1.00 47.50 ? 408 ILE A CG1 1 ATOM 3146 C CG2 . ILE A 1 407 ? -26.340 -4.400 -25.863 1.00 47.35 ? 408 ILE A CG2 1 ATOM 3147 C CD1 . ILE A 1 407 ? -28.891 -2.622 -26.941 1.00 48.86 ? 408 ILE A CD1 1 ATOM 3148 N N . LEU A 1 408 ? -24.882 -2.687 -23.660 1.00 55.54 ? 409 LEU A N 1 ATOM 3149 C CA . LEU A 1 408 ? -23.694 -3.164 -22.976 1.00 53.73 ? 409 LEU A CA 1 ATOM 3150 C C . LEU A 1 408 ? -23.586 -4.686 -23.105 1.00 56.77 ? 409 LEU A C 1 ATOM 3151 O O . LEU A 1 408 ? -24.570 -5.443 -22.907 1.00 58.89 ? 409 LEU A O 1 ATOM 3152 C CB . LEU A 1 408 ? -23.755 -2.761 -21.515 1.00 51.09 ? 409 LEU A CB 1 ATOM 3153 C CG . LEU A 1 408 ? -22.474 -2.948 -20.741 1.00 53.26 ? 409 LEU A CG 1 ATOM 3154 C CD1 . LEU A 1 408 ? -21.358 -2.096 -21.329 1.00 54.01 ? 409 LEU A CD1 1 ATOM 3155 C CD2 . LEU A 1 408 ? -22.721 -2.592 -19.290 1.00 51.09 ? 409 LEU A CD2 1 ATOM 3156 N N . THR A 1 409 ? -22.376 -5.125 -23.430 1.00 56.97 ? 410 THR A N 1 ATOM 3157 C CA . THR A 1 409 ? -22.112 -6.532 -23.701 1.00 54.53 ? 410 THR A CA 1 ATOM 3158 C C . THR A 1 409 ? -20.629 -6.872 -23.599 1.00 55.43 ? 410 THR A C 1 ATOM 3159 O O . THR A 1 409 ? -19.825 -5.985 -23.346 1.00 59.03 ? 410 THR A O 1 ATOM 3160 C CB . THR A 1 409 ? -22.706 -6.941 -25.058 1.00 55.50 ? 410 THR A CB 1 ATOM 3161 O OG1 . THR A 1 409 ? -22.616 -8.360 -25.205 1.00 55.51 ? 410 THR A OG1 1 ATOM 3162 C CG2 . THR A 1 409 ? -22.018 -6.220 -26.215 1.00 57.33 ? 410 THR A CG2 1 ATOM 3163 N N . ALA A 1 410 ? -20.287 -8.158 -23.760 1.00 59.80 ? 411 ALA A N 1 ATOM 3164 C CA . ALA A 1 410 ? -18.891 -8.662 -23.700 1.00 58.12 ? 411 ALA A CA 1 ATOM 3165 C C . ALA A 1 410 ? -18.108 -8.313 -24.968 1.00 59.28 ? 411 ALA A C 1 ATOM 3166 O O . ALA A 1 410 ? -18.673 -8.318 -26.065 1.00 49.55 ? 411 ALA A O 1 ATOM 3167 C CB . ALA A 1 410 ? -18.866 -10.167 -23.468 1.00 49.41 ? 411 ALA A CB 1 ATOM 3168 N N . ALA A 1 411 ? -16.818 -7.989 -24.807 1.00 62.50 ? 412 ALA A N 1 ATOM 3169 C CA . ALA A 1 411 ? -15.926 -7.740 -25.951 1.00 59.27 ? 412 ALA A CA 1 ATOM 3170 C C . ALA A 1 411 ? -15.607 -9.035 -26.701 1.00 62.20 ? 412 ALA A C 1 ATOM 3171 O O . ALA A 1 411 ? -15.506 -9.038 -27.929 1.00 61.77 ? 412 ALA A O 1 ATOM 3172 C CB . ALA A 1 411 ? -14.652 -7.078 -25.491 1.00 54.42 ? 412 ALA A CB 1 ATOM 3173 N N . HIS A 1 412 ? -15.482 -10.142 -25.965 1.00 61.40 ? 413 HIS A N 1 ATOM 3174 C CA . HIS A 1 412 ? -15.100 -11.413 -26.568 1.00 58.16 ? 413 HIS A CA 1 ATOM 3175 C C . HIS A 1 412 ? -16.129 -11.895 -27.527 1.00 59.01 ? 413 HIS A C 1 ATOM 3176 O O . HIS A 1 412 ? -15.888 -12.841 -28.261 1.00 69.17 ? 413 HIS A O 1 ATOM 3177 C CB . HIS A 1 412 ? -14.799 -12.487 -25.521 1.00 63.08 ? 413 HIS A CB 1 ATOM 3178 C CG . HIS A 1 412 ? -16.007 -13.052 -24.843 1.00 68.88 ? 413 HIS A CG 1 ATOM 3179 N ND1 . HIS A 1 412 ? -16.362 -12.710 -23.551 1.00 69.70 ? 413 HIS A ND1 1 ATOM 3180 C CD2 . HIS A 1 412 ? -16.917 -13.965 -25.260 1.00 64.94 ? 413 HIS A CD2 1 ATOM 3181 C CE1 . HIS A 1 412 ? -17.449 -13.378 -23.212 1.00 70.23 ? 413 HIS A CE1 1 ATOM 3182 N NE2 . HIS A 1 412 ? -17.809 -14.140 -24.233 1.00 66.46 ? 413 HIS A NE2 1 ATOM 3183 N N . CYS A 1 413 ? -17.284 -11.248 -27.497 1.00 64.46 ? 414 CYS A N 1 ATOM 3184 C CA . CYS A 1 413 ? -18.383 -11.507 -28.422 1.00 71.28 ? 414 CYS A CA 1 ATOM 3185 C C . CYS A 1 413 ? -18.021 -11.172 -29.875 1.00 71.87 ? 414 CYS A C 1 ATOM 3186 O O . CYS A 1 413 ? -18.555 -11.772 -30.805 1.00 79.26 ? 414 CYS A O 1 ATOM 3187 C CB . CYS A 1 413 ? -19.597 -10.670 -28.004 1.00 83.01 ? 414 CYS A CB 1 ATOM 3188 S SG . CYS A 1 413 ? -20.643 -11.349 -26.700 1.00 83.58 ? 414 CYS A SG 1 ATOM 3189 N N . PHE A 1 414 ? -17.095 -10.234 -30.055 1.00 70.57 ? 415 PHE A N 1 ATOM 3190 C CA . PHE A 1 414 ? -16.857 -9.601 -31.346 1.00 72.28 ? 415 PHE A CA 1 ATOM 3191 C C . PHE A 1 414 ? -15.542 -10.019 -31.999 1.00 75.84 ? 415 PHE A C 1 ATOM 3192 O O . PHE A 1 414 ? -14.861 -9.230 -32.693 1.00 72.95 ? 415 PHE A O 1 ATOM 3193 C CB . PHE A 1 414 ? -16.993 -8.093 -31.168 1.00 74.14 ? 415 PHE A CB 1 ATOM 3194 C CG . PHE A 1 414 ? -18.314 -7.703 -30.601 1.00 77.00 ? 415 PHE A CG 1 ATOM 3195 C CD1 . PHE A 1 414 ? -19.451 -7.687 -31.415 1.00 83.54 ? 415 PHE A CD1 1 ATOM 3196 C CD2 . PHE A 1 414 ? -18.444 -7.417 -29.247 1.00 79.66 ? 415 PHE A CD2 1 ATOM 3197 C CE1 . PHE A 1 414 ? -20.693 -7.366 -30.891 1.00 89.87 ? 415 PHE A CE1 1 ATOM 3198 C CE2 . PHE A 1 414 ? -19.682 -7.096 -28.718 1.00 86.05 ? 415 PHE A CE2 1 ATOM 3199 C CZ . PHE A 1 414 ? -20.806 -7.079 -29.537 1.00 93.80 ? 415 PHE A CZ 1 ATOM 3200 N N . TYR A 1 415 ? -15.224 -11.292 -31.793 1.00 75.71 ? 416 TYR A N 1 ATOM 3201 C CA . TYR A 1 415 ? -13.992 -11.859 -32.255 1.00 76.12 ? 416 TYR A CA 1 ATOM 3202 C C . TYR A 1 415 ? -14.063 -12.075 -33.757 1.00 78.30 ? 416 TYR A C 1 ATOM 3203 O O . TYR A 1 415 ? -14.977 -12.748 -34.261 1.00 73.01 ? 416 TYR A O 1 ATOM 3204 C CB . TYR A 1 415 ? -13.725 -13.152 -31.527 1.00 77.43 ? 416 TYR A CB 1 ATOM 3205 C CG . TYR A 1 415 ? -12.425 -13.770 -31.920 1.00 89.14 ? 416 TYR A CG 1 ATOM 3206 C CD1 . TYR A 1 415 ? -11.260 -12.985 -32.042 1.00 88.95 ? 416 TYR A CD1 1 ATOM 3207 C CD2 . TYR A 1 415 ? -12.339 -15.144 -32.166 1.00 91.46 ? 416 TYR A CD2 1 ATOM 3208 C CE1 . TYR A 1 415 ? -10.051 -13.555 -32.405 1.00 91.53 ? 416 TYR A CE1 1 ATOM 3209 C CE2 . TYR A 1 415 ? -11.131 -15.722 -32.521 1.00 98.45 ? 416 TYR A CE2 1 ATOM 3210 C CZ . TYR A 1 415 ? -9.996 -14.924 -32.638 1.00 97.54 ? 416 TYR A CZ 1 ATOM 3211 O OH . TYR A 1 415 ? -8.802 -15.498 -32.994 1.00 119.04 ? 416 TYR A OH 1 ATOM 3212 N N . GLY A 1 416 ? -13.111 -11.457 -34.461 1.00 77.85 ? 417 GLY A N 1 ATOM 3213 C CA . GLY A 1 416 ? -13.104 -11.430 -35.923 1.00 79.10 ? 417 GLY A CA 1 ATOM 3214 C C . GLY A 1 416 ? -14.439 -11.025 -36.540 1.00 82.02 ? 417 GLY A C 1 ATOM 3215 O O . GLY A 1 416 ? -14.842 -11.546 -37.577 1.00 86.48 ? 417 GLY A O 1 ATOM 3216 N N . VAL A 1 417 ? -15.156 -10.122 -35.884 1.00 81.48 ? 418 VAL A N 1 ATOM 3217 C CA . VAL A 1 417 ? -16.199 -9.380 -36.574 1.00 79.12 ? 418 VAL A CA 1 ATOM 3218 C C . VAL A 1 417 ? -15.416 -8.261 -37.258 1.00 75.66 ? 418 VAL A C 1 ATOM 3219 O O . VAL A 1 417 ? -14.639 -7.576 -36.606 1.00 78.53 ? 418 VAL A O 1 ATOM 3220 C CB . VAL A 1 417 ? -17.307 -8.862 -35.611 1.00 72.54 ? 418 VAL A CB 1 ATOM 3221 C CG1 . VAL A 1 417 ? -18.130 -7.747 -36.253 1.00 68.56 ? 418 VAL A CG1 1 ATOM 3222 C CG2 . VAL A 1 417 ? -18.219 -10.003 -35.168 1.00 63.85 ? 418 VAL A CG2 1 ATOM 3223 N N . GLU A 1 418 ? -15.568 -8.109 -38.566 1.00 73.69 ? 419 GLU A N 1 ATOM 3224 C CA . GLU A 1 418 ? -14.795 -7.082 -39.261 1.00 76.98 ? 419 GLU A CA 1 ATOM 3225 C C . GLU A 1 418 ? -15.484 -5.715 -39.294 1.00 79.46 ? 419 GLU A C 1 ATOM 3226 O O . GLU A 1 418 ? -14.810 -4.699 -39.169 1.00 91.57 ? 419 GLU A O 1 ATOM 3227 C CB . GLU A 1 418 ? -14.385 -7.520 -40.678 1.00 76.05 ? 419 GLU A CB 1 ATOM 3228 C CG . GLU A 1 418 ? -13.744 -8.897 -40.765 1.00 79.91 ? 419 GLU A CG 1 ATOM 3229 C CD . GLU A 1 418 ? -13.677 -9.449 -42.182 1.00 86.83 ? 419 GLU A CD 1 ATOM 3230 O OE1 . GLU A 1 418 ? -13.631 -8.659 -43.150 1.00 87.83 ? 419 GLU A OE1 1 ATOM 3231 O OE2 . GLU A 1 418 ? -13.662 -10.692 -42.334 1.00 96.19 ? 419 GLU A OE2 1 ATOM 3232 N N . SER A 1 419 ? -16.807 -5.697 -39.485 1.00 78.92 ? 420 SER A N 1 ATOM 3233 C CA . SER A 1 419 ? -17.591 -4.462 -39.679 1.00 80.84 ? 420 SER A CA 1 ATOM 3234 C C . SER A 1 419 ? -18.807 -4.513 -38.763 1.00 85.86 ? 420 SER A C 1 ATOM 3235 O O . SER A 1 419 ? -19.323 -5.609 -38.521 1.00 88.53 ? 420 SER A O 1 ATOM 3236 C CB . SER A 1 419 ? -18.035 -4.314 -41.144 1.00 85.23 ? 420 SER A CB 1 ATOM 3237 O OG . SER A 1 419 ? -19.099 -3.383 -41.316 1.00 91.78 ? 420 SER A OG 1 ATOM 3238 N N . PRO A 1 420 ? -19.262 -3.338 -38.234 1.00 79.89 ? 421 PRO A N 1 ATOM 3239 C CA . PRO A 1 420 ? -20.500 -3.302 -37.442 1.00 67.61 ? 421 PRO A CA 1 ATOM 3240 C C . PRO A 1 420 ? -21.689 -3.694 -38.282 1.00 68.72 ? 421 PRO A C 1 ATOM 3241 O O . PRO A 1 420 ? -22.710 -4.106 -37.734 1.00 76.37 ? 421 PRO A O 1 ATOM 3242 C CB . PRO A 1 420 ? -20.611 -1.845 -37.048 1.00 64.43 ? 421 PRO A CB 1 ATOM 3243 C CG . PRO A 1 420 ? -19.192 -1.395 -36.965 1.00 66.85 ? 421 PRO A CG 1 ATOM 3244 C CD . PRO A 1 420 ? -18.553 -2.045 -38.153 1.00 72.14 ? 421 PRO A CD 1 ATOM 3245 N N . LYS A 1 421 ? -21.532 -3.614 -39.605 1.00 70.53 ? 422 LYS A N 1 ATOM 3246 C CA . LYS A 1 421 ? -22.629 -3.858 -40.548 1.00 71.61 ? 422 LYS A CA 1 ATOM 3247 C C . LYS A 1 421 ? -23.049 -5.331 -40.689 1.00 65.40 ? 422 LYS A C 1 ATOM 3248 O O . LYS A 1 421 ? -23.922 -5.652 -41.483 1.00 61.71 ? 422 LYS A O 1 ATOM 3249 C CB . LYS A 1 421 ? -22.335 -3.198 -41.907 1.00 74.13 ? 422 LYS A CB 1 ATOM 3250 C CG . LYS A 1 421 ? -22.531 -1.685 -41.926 1.00 79.12 ? 422 LYS A CG 1 ATOM 3251 C CD . LYS A 1 421 ? -24.008 -1.334 -42.050 1.00 81.00 ? 422 LYS A CD 1 ATOM 3252 C CE . LYS A 1 421 ? -24.249 -0.242 -43.084 1.00 86.33 ? 422 LYS A CE 1 ATOM 3253 N NZ . LYS A 1 421 ? -25.567 -0.447 -43.755 1.00 84.52 ? 422 LYS A NZ 1 ATOM 3254 N N . ILE A 1 422 ? -22.452 -6.216 -39.900 1.00 63.19 ? 423 ILE A N 1 ATOM 3255 C CA . ILE A 1 422 ? -22.820 -7.633 -39.915 1.00 66.62 ? 423 ILE A CA 1 ATOM 3256 C C . ILE A 1 422 ? -23.810 -7.927 -38.784 1.00 70.40 ? 423 ILE A C 1 ATOM 3257 O O . ILE A 1 422 ? -24.389 -9.031 -38.696 1.00 72.63 ? 423 ILE A O 1 ATOM 3258 C CB . ILE A 1 422 ? -21.561 -8.528 -39.809 1.00 69.02 ? 423 ILE A CB 1 ATOM 3259 C CG1 . ILE A 1 422 ? -21.899 -10.013 -39.972 1.00 70.15 ? 423 ILE A CG1 1 ATOM 3260 C CG2 . ILE A 1 422 ? -20.831 -8.291 -38.495 1.00 74.46 ? 423 ILE A CG2 1 ATOM 3261 C CD1 . ILE A 1 422 ? -20.761 -10.950 -39.638 1.00 73.60 ? 423 ILE A CD1 1 ATOM 3262 N N . LEU A 1 423 ? -24.006 -6.918 -37.932 1.00 67.91 ? 424 LEU A N 1 ATOM 3263 C CA . LEU A 1 423 ? -24.771 -7.069 -36.689 1.00 67.41 ? 424 LEU A CA 1 ATOM 3264 C C . LEU A 1 423 ? -26.259 -6.709 -36.780 1.00 68.74 ? 424 LEU A C 1 ATOM 3265 O O . LEU A 1 423 ? -26.662 -5.842 -37.565 1.00 63.86 ? 424 LEU A O 1 ATOM 3266 C CB . LEU A 1 423 ? -24.105 -6.276 -35.554 1.00 59.67 ? 424 LEU A CB 1 ATOM 3267 C CG . LEU A 1 423 ? -22.716 -6.723 -35.102 1.00 53.70 ? 424 LEU A CG 1 ATOM 3268 C CD1 . LEU A 1 423 ? -22.188 -5.763 -34.047 1.00 54.19 ? 424 LEU A CD1 1 ATOM 3269 C CD2 . LEU A 1 423 ? -22.727 -8.162 -34.586 1.00 53.08 ? 424 LEU A CD2 1 ATOM 3270 N N . ARG A 1 424 ? -27.052 -7.396 -35.958 1.00 70.82 ? 425 ARG A N 1 ATOM 3271 C CA . ARG A 1 424 ? -28.487 -7.151 -35.815 1.00 75.13 ? 425 ARG A CA 1 ATOM 3272 C C . ARG A 1 424 ? -28.969 -7.355 -34.369 1.00 75.39 ? 425 ARG A C 1 ATOM 3273 O O . ARG A 1 424 ? -28.974 -8.479 -33.864 1.00 74.10 ? 425 ARG A O 1 ATOM 3274 C CB . ARG A 1 424 ? -29.289 -8.067 -36.748 1.00 78.48 ? 425 ARG A CB 1 ATOM 3275 C CG . ARG A 1 424 ? -29.318 -7.650 -38.206 1.00 77.12 ? 425 ARG A CG 1 ATOM 3276 C CD . ARG A 1 424 ? -30.121 -8.653 -39.017 1.00 78.01 ? 425 ARG A CD 1 ATOM 3277 N NE . ARG A 1 424 ? -30.132 -8.284 -40.427 1.00 76.63 ? 425 ARG A NE 1 ATOM 3278 C CZ . ARG A 1 424 ? -30.837 -8.892 -41.372 1.00 70.52 ? 425 ARG A CZ 1 ATOM 3279 N NH1 . ARG A 1 424 ? -31.599 -9.930 -41.081 1.00 73.87 ? 425 ARG A NH1 1 ATOM 3280 N NH2 . ARG A 1 424 ? -30.771 -8.455 -42.620 1.00 70.60 ? 425 ARG A NH2 1 ATOM 3281 N N . VAL A 1 425 ? -29.396 -6.268 -33.726 1.00 75.00 ? 426 VAL A N 1 ATOM 3282 C CA . VAL A 1 425 ? -29.972 -6.321 -32.378 1.00 74.47 ? 426 VAL A CA 1 ATOM 3283 C C . VAL A 1 425 ? -31.497 -6.411 -32.429 1.00 75.33 ? 426 VAL A C 1 ATOM 3284 O O . VAL A 1 425 ? -32.166 -5.619 -33.101 1.00 79.80 ? 426 VAL A O 1 ATOM 3285 C CB . VAL A 1 425 ? -29.591 -5.085 -31.544 1.00 74.37 ? 426 VAL A CB 1 ATOM 3286 C CG1 . VAL A 1 425 ? -29.737 -5.381 -30.063 1.00 79.39 ? 426 VAL A CG1 1 ATOM 3287 C CG2 . VAL A 1 425 ? -28.179 -4.625 -31.857 1.00 70.33 ? 426 VAL A CG2 1 ATOM 3288 N N . TYR A 1 426 ? -32.038 -7.377 -31.705 1.00 76.68 ? 427 TYR A N 1 ATOM 3289 C CA . TYR A 1 426 ? -33.479 -7.527 -31.582 1.00 84.30 ? 427 TYR A CA 1 ATOM 3290 C C . TYR A 1 426 ? -33.883 -7.366 -30.118 1.00 89.85 ? 427 TYR A C 1 ATOM 3291 O O . TYR A 1 426 ? -33.214 -7.900 -29.219 1.00 91.73 ? 427 TYR A O 1 ATOM 3292 C CB . TYR A 1 426 ? -33.934 -8.889 -32.104 1.00 89.72 ? 427 TYR A CB 1 ATOM 3293 C CG . TYR A 1 426 ? -33.673 -9.142 -33.575 1.00 97.71 ? 427 TYR A CG 1 ATOM 3294 C CD1 . TYR A 1 426 ? -32.435 -9.634 -34.013 1.00 99.88 ? 427 TYR A CD1 1 ATOM 3295 C CD2 . TYR A 1 426 ? -34.673 -8.923 -34.531 1.00 102.67 ? 427 TYR A CD2 1 ATOM 3296 C CE1 . TYR A 1 426 ? -32.194 -9.878 -35.360 1.00 100.24 ? 427 TYR A CE1 1 ATOM 3297 C CE2 . TYR A 1 426 ? -34.439 -9.167 -35.880 1.00 106.36 ? 427 TYR A CE2 1 ATOM 3298 C CZ . TYR A 1 426 ? -33.199 -9.643 -36.284 1.00 100.93 ? 427 TYR A CZ 1 ATOM 3299 O OH . TYR A 1 426 ? -32.955 -9.881 -37.606 1.00 103.80 ? 427 TYR A OH 1 ATOM 3300 N N . SER A 1 427 ? -34.972 -6.622 -29.895 1.00 90.04 ? 428 SER A N 1 ATOM 3301 C CA . SER A 1 427 ? -35.524 -6.371 -28.554 1.00 83.95 ? 428 SER A CA 1 ATOM 3302 C C . SER A 1 427 ? -36.862 -7.067 -28.323 1.00 80.80 ? 428 SER A C 1 ATOM 3303 O O . SER A 1 427 ? -37.510 -7.492 -29.273 1.00 74.10 ? 428 SER A O 1 ATOM 3304 C CB . SER A 1 427 ? -35.610 -4.865 -28.247 1.00 76.98 ? 428 SER A CB 1 ATOM 3305 O OG . SER A 1 427 ? -35.999 -4.108 -29.368 1.00 74.54 ? 428 SER A OG 1 ATOM 3306 N N . GLY A 1 428 ? -37.232 -7.210 -27.049 1.00 86.34 ? 429 GLY A N 1 ATOM 3307 C CA . GLY A 1 428 ? -38.463 -7.887 -26.628 1.00 93.30 ? 429 GLY A CA 1 ATOM 3308 C C . GLY A 1 428 ? -38.706 -9.223 -27.310 1.00 88.78 ? 429 GLY A C 1 ATOM 3309 O O . GLY A 1 428 ? -39.776 -9.450 -27.886 1.00 81.73 ? 429 GLY A O 1 ATOM 3310 N N . ILE A 1 429 ? -37.704 -10.096 -27.266 1.00 84.87 ? 430 ILE A N 1 ATOM 3311 C CA . ILE A 1 429 ? -37.802 -11.393 -27.935 1.00 83.15 ? 430 ILE A CA 1 ATOM 3312 C C . ILE A 1 429 ? -37.788 -12.514 -26.907 1.00 90.32 ? 430 ILE A C 1 ATOM 3313 O O . ILE A 1 429 ? -37.017 -12.488 -25.937 1.00 89.21 ? 430 ILE A O 1 ATOM 3314 C CB . ILE A 1 429 ? -36.706 -11.604 -29.032 1.00 69.91 ? 430 ILE A CB 1 ATOM 3315 C CG1 . ILE A 1 429 ? -36.715 -10.479 -30.070 1.00 62.79 ? 430 ILE A CG1 1 ATOM 3316 C CG2 . ILE A 1 429 ? -36.853 -12.950 -29.734 1.00 65.65 ? 430 ILE A CG2 1 ATOM 3317 C CD1 . ILE A 1 429 ? -37.847 -10.524 -31.080 1.00 63.10 ? 430 ILE A CD1 1 ATOM 3318 N N . LEU A 1 430 ? -38.638 -13.505 -27.158 1.00 95.83 ? 431 LEU A N 1 ATOM 3319 C CA . LEU A 1 430 ? -38.795 -14.644 -26.281 1.00 101.51 ? 431 LEU A CA 1 ATOM 3320 C C . LEU A 1 430 ? -38.379 -15.955 -26.976 1.00 108.01 ? 431 LEU A C 1 ATOM 3321 O O . LEU A 1 430 ? -37.345 -16.563 -26.633 1.00 99.78 ? 431 LEU A O 1 ATOM 3322 C CB . LEU A 1 430 ? -40.247 -14.662 -25.817 1.00 99.55 ? 431 LEU A CB 1 ATOM 3323 C CG . LEU A 1 430 ? -40.770 -15.535 -24.692 1.00 100.93 ? 431 LEU A CG 1 ATOM 3324 C CD1 . LEU A 1 430 ? -39.842 -15.590 -23.487 1.00 95.56 ? 431 LEU A CD1 1 ATOM 3325 C CD2 . LEU A 1 430 ? -42.120 -14.939 -24.340 1.00 106.40 ? 431 LEU A CD2 1 ATOM 3326 N N . ASN A 1 431 ? -39.191 -16.386 -27.944 1.00 111.91 ? 432 ASN A N 1 ATOM 3327 C CA . ASN A 1 431 ? -38.831 -17.507 -28.799 1.00 111.76 ? 432 ASN A CA 1 ATOM 3328 C C . ASN A 1 431 ? -37.969 -16.933 -29.914 1.00 107.88 ? 432 ASN A C 1 ATOM 3329 O O . ASN A 1 431 ? -38.276 -15.857 -30.442 1.00 96.11 ? 432 ASN A O 1 ATOM 3330 C CB . ASN A 1 431 ? -40.080 -18.316 -29.279 1.00 121.88 ? 432 ASN A CB 1 ATOM 3331 C CG . ASN A 1 431 ? -40.600 -19.306 -28.203 1.00 125.72 ? 432 ASN A CG 1 ATOM 3332 O OD1 . ASN A 1 431 ? -40.135 -19.256 -27.076 1.00 126.29 ? 432 ASN A OD1 1 ATOM 3333 N ND2 . ASN A 1 431 ? -41.537 -20.211 -28.531 1.00 122.34 ? 432 ASN A ND2 1 ATOM 3334 N N . GLN A 1 432 ? -36.846 -17.602 -30.197 1.00 103.35 ? 433 GLN A N 1 ATOM 3335 C CA . GLN A 1 432 ? -35.994 -17.275 -31.353 1.00 91.38 ? 433 GLN A CA 1 ATOM 3336 C C . GLN A 1 432 ? -36.767 -17.538 -32.643 1.00 96.12 ? 433 GLN A C 1 ATOM 3337 O O . GLN A 1 432 ? -36.605 -16.805 -33.629 1.00 86.61 ? 433 GLN A O 1 ATOM 3338 C CB . GLN A 1 432 ? -34.714 -18.102 -31.330 1.00 85.90 ? 433 GLN A CB 1 ATOM 3339 C CG . GLN A 1 432 ? -33.731 -17.720 -30.234 1.00 89.66 ? 433 GLN A CG 1 ATOM 3340 C CD . GLN A 1 432 ? -32.824 -16.534 -30.581 1.00 95.35 ? 433 GLN A CD 1 ATOM 3341 O OE1 . GLN A 1 432 ? -33.126 -15.707 -31.447 1.00 90.86 ? 433 GLN A OE1 1 ATOM 3342 N NE2 . GLN A 1 432 ? -31.698 -16.445 -29.877 1.00 96.42 ? 433 GLN A NE2 1 ATOM 3343 N N . SER A 1 433 ? -37.588 -18.604 -32.595 1.00 101.51 ? 434 SER A N 1 ATOM 3344 C CA . SER A 1 433 ? -38.734 -18.906 -33.486 1.00 98.41 ? 434 SER A CA 1 ATOM 3345 C C . SER A 1 433 ? -39.486 -17.670 -34.018 1.00 99.38 ? 434 SER A C 1 ATOM 3346 O O . SER A 1 433 ? -39.844 -17.607 -35.195 1.00 94.15 ? 434 SER A O 1 ATOM 3347 C CB . SER A 1 433 ? -39.704 -19.836 -32.725 1.00 102.95 ? 434 SER A CB 1 ATOM 3348 O OG . SER A 1 433 ? -41.016 -19.869 -33.271 1.00 117.15 ? 434 SER A OG 1 ATOM 3349 N N . GLU A 1 434 ? -39.705 -16.702 -33.126 1.00 106.03 ? 435 GLU A N 1 ATOM 3350 C CA . GLU A 1 434 ? -40.377 -15.424 -33.391 1.00 100.10 ? 435 GLU A CA 1 ATOM 3351 C C . GLU A 1 434 ? -39.626 -14.504 -34.369 1.00 96.24 ? 435 GLU A C 1 ATOM 3352 O O . GLU A 1 434 ? -40.204 -13.532 -34.858 1.00 90.10 ? 435 GLU A O 1 ATOM 3353 C CB . GLU A 1 434 ? -40.625 -14.723 -32.040 1.00 106.32 ? 435 GLU A CB 1 ATOM 3354 C CG . GLU A 1 434 ? -41.153 -13.289 -32.065 1.00 113.65 ? 435 GLU A CG 1 ATOM 3355 C CD . GLU A 1 434 ? -40.865 -12.506 -30.784 1.00 117.68 ? 435 GLU A CD 1 ATOM 3356 O OE1 . GLU A 1 434 ? -40.406 -13.101 -29.769 1.00 112.24 ? 435 GLU A OE1 1 ATOM 3357 O OE2 . GLU A 1 434 ? -41.108 -11.276 -30.803 1.00 114.13 ? 435 GLU A OE2 1 ATOM 3358 N N . ILE A 1 435 ? -38.351 -14.796 -34.644 1.00 101.52 ? 436 ILE A N 1 ATOM 3359 C CA . ILE A 1 435 ? -37.581 -13.989 -35.601 1.00 101.11 ? 436 ILE A CA 1 ATOM 3360 C C . ILE A 1 435 ? -37.673 -14.542 -37.015 1.00 101.28 ? 436 ILE A C 1 ATOM 3361 O O . ILE A 1 435 ? -37.334 -15.706 -37.256 1.00 102.00 ? 436 ILE A O 1 ATOM 3362 C CB . ILE A 1 435 ? -36.090 -13.824 -35.253 1.00 97.26 ? 436 ILE A CB 1 ATOM 3363 C CG1 . ILE A 1 435 ? -35.841 -13.832 -33.746 1.00 96.06 ? 436 ILE A CG1 1 ATOM 3364 C CG2 . ILE A 1 435 ? -35.591 -12.522 -35.865 1.00 102.47 ? 436 ILE A CG2 1 ATOM 3365 C CD1 . ILE A 1 435 ? -34.381 -13.942 -33.373 1.00 87.07 ? 436 ILE A CD1 1 ATOM 3366 N N . LYS A 1 436 ? -38.130 -13.676 -37.923 1.00 98.96 ? 437 LYS A N 1 ATOM 3367 C CA . LYS A 1 436 ? -38.315 -13.948 -39.357 1.00 99.99 ? 437 LYS A CA 1 ATOM 3368 C C . LYS A 1 436 ? -37.821 -12.687 -40.113 1.00 107.71 ? 437 LYS A C 1 ATOM 3369 O O . LYS A 1 436 ? -37.615 -11.649 -39.489 1.00 107.08 ? 437 LYS A O 1 ATOM 3370 C CB . LYS A 1 436 ? -39.798 -14.219 -39.682 1.00 97.28 ? 437 LYS A CB 1 ATOM 3371 C CG . LYS A 1 436 ? -40.665 -14.862 -38.592 1.00 96.98 ? 437 LYS A CG 1 ATOM 3372 C CD . LYS A 1 436 ? -42.026 -14.159 -38.485 1.00 107.60 ? 437 LYS A CD 1 ATOM 3373 C CE . LYS A 1 436 ? -43.049 -14.920 -37.628 1.00 108.12 ? 437 LYS A CE 1 ATOM 3374 N NZ . LYS A 1 436 ? -44.481 -14.554 -37.889 1.00 90.20 ? 437 LYS A NZ 1 ATOM 3375 N N . GLU A 1 437 ? -37.645 -12.767 -41.439 1.00 112.07 ? 438 GLU A N 1 ATOM 3376 C CA . GLU A 1 437 ? -37.050 -11.668 -42.264 1.00 104.79 ? 438 GLU A CA 1 ATOM 3377 C C . GLU A 1 437 ? -37.795 -10.357 -42.123 1.00 102.04 ? 438 GLU A C 1 ATOM 3378 O O . GLU A 1 437 ? -37.188 -9.287 -42.162 1.00 103.58 ? 438 GLU A O 1 ATOM 3379 C CB . GLU A 1 437 ? -37.012 -12.005 -43.765 1.00 102.43 ? 438 GLU A CB 1 ATOM 3380 C CG . GLU A 1 437 ? -36.392 -13.336 -44.156 1.00 114.84 ? 438 GLU A CG 1 ATOM 3381 C CD . GLU A 1 437 ? -37.209 -14.542 -43.701 1.00 127.87 ? 438 GLU A CD 1 ATOM 3382 O OE1 . GLU A 1 437 ? -38.439 -14.417 -43.448 1.00 126.07 ? 438 GLU A OE1 1 ATOM 3383 O OE2 . GLU A 1 437 ? -36.606 -15.626 -43.573 1.00 139.19 ? 438 GLU A OE2 1 ATOM 3384 N N . ASP A 1 438 ? -39.118 -10.460 -41.999 1.00 103.58 ? 439 ASP A N 1 ATOM 3385 C CA . ASP A 1 438 ? -39.996 -9.310 -41.788 1.00 102.02 ? 439 ASP A CA 1 ATOM 3386 C C . ASP A 1 438 ? -39.716 -8.623 -40.439 1.00 100.03 ? 439 ASP A C 1 ATOM 3387 O O . ASP A 1 438 ? -39.699 -7.393 -40.384 1.00 100.99 ? 439 ASP A O 1 ATOM 3388 C CB . ASP A 1 438 ? -41.490 -9.678 -41.981 1.00 104.82 ? 439 ASP A CB 1 ATOM 3389 C CG . ASP A 1 438 ? -41.790 -11.170 -41.725 1.00 111.18 ? 439 ASP A CG 1 ATOM 3390 O OD1 . ASP A 1 438 ? -41.342 -11.720 -40.696 1.00 117.73 ? 439 ASP A OD1 1 ATOM 3391 O OD2 . ASP A 1 438 ? -42.486 -11.796 -42.554 1.00 109.65 ? 439 ASP A OD2 1 ATOM 3392 N N . THR A 1 439 ? -39.456 -9.418 -39.388 1.00 89.07 ? 440 THR A N 1 ATOM 3393 C CA . THR A 1 439 ? -39.071 -8.931 -38.050 1.00 82.19 ? 440 THR A CA 1 ATOM 3394 C C . THR A 1 439 ? -38.132 -7.723 -38.125 1.00 83.75 ? 440 THR A C 1 ATOM 3395 O O . THR A 1 439 ? -37.083 -7.790 -38.763 1.00 85.47 ? 440 THR A O 1 ATOM 3396 C CB . THR A 1 439 ? -38.349 -10.040 -37.260 1.00 79.44 ? 440 THR A CB 1 ATOM 3397 O OG1 . THR A 1 439 ? -39.122 -11.246 -37.303 1.00 75.84 ? 440 THR A OG1 1 ATOM 3398 C CG2 . THR A 1 439 ? -38.072 -9.622 -35.820 1.00 76.31 ? 440 THR A CG2 1 ATOM 3399 N N . SER A 1 440 ? -38.514 -6.622 -37.491 1.00 83.48 ? 441 SER A N 1 ATOM 3400 C CA . SER A 1 440 ? -37.653 -5.449 -37.472 1.00 87.08 ? 441 SER A CA 1 ATOM 3401 C C . SER A 1 440 ? -36.486 -5.653 -36.491 1.00 90.65 ? 441 SER A C 1 ATOM 3402 O O . SER A 1 440 ? -36.603 -6.463 -35.559 1.00 88.66 ? 441 SER A O 1 ATOM 3403 C CB . SER A 1 440 ? -38.460 -4.210 -37.114 1.00 90.97 ? 441 SER A CB 1 ATOM 3404 O OG . SER A 1 440 ? -37.754 -3.048 -37.505 1.00 99.45 ? 441 SER A OG 1 ATOM 3405 N N . PHE A 1 441 ? -35.369 -4.946 -36.722 1.00 81.68 ? 442 PHE A N 1 ATOM 3406 C CA . PHE A 1 441 ? -34.188 -4.976 -35.824 1.00 79.44 ? 442 PHE A CA 1 ATOM 3407 C C . PHE A 1 441 ? -33.487 -3.607 -35.755 1.00 72.23 ? 442 PHE A C 1 ATOM 3408 O O . PHE A 1 441 ? -33.744 -2.746 -36.591 1.00 71.08 ? 442 PHE A O 1 ATOM 3409 C CB . PHE A 1 441 ? -33.177 -6.051 -36.281 1.00 77.01 ? 442 PHE A CB 1 ATOM 3410 C CG . PHE A 1 441 ? -32.551 -5.751 -37.607 1.00 78.36 ? 442 PHE A CG 1 ATOM 3411 C CD1 . PHE A 1 441 ? -31.471 -4.841 -37.703 1.00 75.56 ? 442 PHE A CD1 1 ATOM 3412 C CD2 . PHE A 1 441 ? -33.059 -6.328 -38.770 1.00 73.17 ? 442 PHE A CD2 1 ATOM 3413 C CE1 . PHE A 1 441 ? -30.913 -4.517 -38.928 1.00 66.10 ? 442 PHE A CE1 1 ATOM 3414 C CE2 . PHE A 1 441 ? -32.504 -6.011 -39.998 1.00 66.74 ? 442 PHE A CE2 1 ATOM 3415 C CZ . PHE A 1 441 ? -31.429 -5.113 -40.072 1.00 68.45 ? 442 PHE A CZ 1 ATOM 3416 N N . PHE A 1 442 ? -32.578 -3.437 -34.792 1.00 68.43 ? 443 PHE A N 1 ATOM 3417 C CA . PHE A 1 442 ? -31.717 -2.243 -34.709 1.00 76.06 ? 443 PHE A CA 1 ATOM 3418 C C . PHE A 1 442 ? -30.340 -2.522 -35.315 1.00 81.10 ? 443 PHE A C 1 ATOM 3419 O O . PHE A 1 442 ? -29.693 -3.525 -34.979 1.00 86.30 ? 443 PHE A O 1 ATOM 3420 C CB . PHE A 1 442 ? -31.540 -1.768 -33.253 1.00 73.96 ? 443 PHE A CB 1 ATOM 3421 C CG . PHE A 1 442 ? -32.817 -1.324 -32.593 1.00 80.41 ? 443 PHE A CG 1 ATOM 3422 C CD1 . PHE A 1 442 ? -33.706 -2.261 -32.030 1.00 82.11 ? 443 PHE A CD1 1 ATOM 3423 C CD2 . PHE A 1 442 ? -33.139 0.031 -32.520 1.00 77.71 ? 443 PHE A CD2 1 ATOM 3424 C CE1 . PHE A 1 442 ? -34.890 -1.853 -31.422 1.00 75.39 ? 443 PHE A CE1 1 ATOM 3425 C CE2 . PHE A 1 442 ? -34.321 0.442 -31.914 1.00 76.91 ? 443 PHE A CE2 1 ATOM 3426 C CZ . PHE A 1 442 ? -35.192 -0.501 -31.363 1.00 80.01 ? 443 PHE A CZ 1 ATOM 3427 N N . GLY A 1 443 ? -29.888 -1.638 -36.199 1.00 75.95 ? 444 GLY A N 1 ATOM 3428 C CA . GLY A 1 443 ? -28.560 -1.760 -36.771 1.00 67.83 ? 444 GLY A CA 1 ATOM 3429 C C . GLY A 1 443 ? -27.522 -1.045 -35.931 1.00 67.17 ? 444 GLY A C 1 ATOM 3430 O O . GLY A 1 443 ? -27.694 0.129 -35.622 1.00 74.08 ? 444 GLY A O 1 ATOM 3431 N N . VAL A 1 444 ? -26.440 -1.746 -35.579 1.00 65.71 ? 445 VAL A N 1 ATOM 3432 C CA . VAL A 1 444 ? -25.297 -1.158 -34.837 1.00 65.27 ? 445 VAL A CA 1 ATOM 3433 C C . VAL A 1 444 ? -24.464 -0.173 -35.682 1.00 67.03 ? 445 VAL A C 1 ATOM 3434 O O . VAL A 1 444 ? -23.823 -0.550 -36.670 1.00 70.29 ? 445 VAL A O 1 ATOM 3435 C CB . VAL A 1 444 ? -24.349 -2.251 -34.262 1.00 63.09 ? 445 VAL A CB 1 ATOM 3436 C CG1 . VAL A 1 444 ? -23.245 -1.657 -33.388 1.00 56.50 ? 445 VAL A CG1 1 ATOM 3437 C CG2 . VAL A 1 444 ? -25.126 -3.284 -33.484 1.00 63.63 ? 445 VAL A CG2 1 ATOM 3438 N N . GLN A 1 445 ? -24.451 1.086 -35.273 1.00 67.28 ? 446 GLN A N 1 ATOM 3439 C CA . GLN A 1 445 ? -23.573 2.066 -35.885 1.00 68.75 ? 446 GLN A CA 1 ATOM 3440 C C . GLN A 1 445 ? -22.120 1.768 -35.542 1.00 67.33 ? 446 GLN A C 1 ATOM 3441 O O . GLN A 1 445 ? -21.260 1.879 -36.405 1.00 81.66 ? 446 GLN A O 1 ATOM 3442 C CB . GLN A 1 445 ? -23.968 3.474 -35.452 1.00 72.10 ? 446 GLN A CB 1 ATOM 3443 C CG . GLN A 1 445 ? -22.941 4.574 -35.676 1.00 82.21 ? 446 GLN A CG 1 ATOM 3444 C CD . GLN A 1 445 ? -23.453 5.928 -35.220 1.00 95.24 ? 446 GLN A CD 1 ATOM 3445 O OE1 . GLN A 1 445 ? -24.662 6.128 -35.033 1.00 101.44 ? 446 GLN A OE1 1 ATOM 3446 N NE2 . GLN A 1 445 ? -22.539 6.866 -35.038 1.00 96.89 ? 446 GLN A NE2 1 ATOM 3447 N N . GLU A 1 446 ? -21.840 1.369 -34.307 1.00 62.89 ? 447 GLU A N 1 ATOM 3448 C CA . GLU A 1 446 ? -20.452 1.359 -33.834 1.00 68.12 ? 447 GLU A CA 1 ATOM 3449 C C . GLU A 1 446 ? -20.169 0.374 -32.693 1.00 69.49 ? 447 GLU A C 1 ATOM 3450 O O . GLU A 1 446 ? -21.027 0.136 -31.846 1.00 71.78 ? 447 GLU A O 1 ATOM 3451 C CB . GLU A 1 446 ? -20.057 2.784 -33.455 1.00 67.47 ? 447 GLU A CB 1 ATOM 3452 C CG . GLU A 1 446 ? -18.725 2.969 -32.769 1.00 79.38 ? 447 GLU A CG 1 ATOM 3453 C CD . GLU A 1 446 ? -18.543 4.398 -32.307 1.00 99.69 ? 447 GLU A CD 1 ATOM 3454 O OE1 . GLU A 1 446 ? -19.556 5.132 -32.188 1.00 107.66 ? 447 GLU A OE1 1 ATOM 3455 O OE2 . GLU A 1 446 ? -17.384 4.797 -32.063 1.00 113.08 ? 447 GLU A OE2 1 ATOM 3456 N N . ILE A 1 447 ? -18.965 -0.205 -32.698 1.00 66.12 ? 448 ILE A N 1 ATOM 3457 C CA . ILE A 1 447 ? -18.518 -1.095 -31.621 1.00 58.02 ? 448 ILE A CA 1 ATOM 3458 C C . ILE A 1 447 ? -17.409 -0.426 -30.824 1.00 56.12 ? 448 ILE A C 1 ATOM 3459 O O . ILE A 1 447 ? -16.342 -0.119 -31.349 1.00 57.33 ? 448 ILE A O 1 ATOM 3460 C CB . ILE A 1 447 ? -18.080 -2.510 -32.107 1.00 50.43 ? 448 ILE A CB 1 ATOM 3461 C CG1 . ILE A 1 447 ? -19.203 -3.172 -32.890 1.00 49.08 ? 448 ILE A CG1 1 ATOM 3462 C CG2 . ILE A 1 447 ? -17.746 -3.400 -30.917 1.00 47.86 ? 448 ILE A CG2 1 ATOM 3463 C CD1 . ILE A 1 447 ? -18.763 -4.182 -33.925 1.00 53.41 ? 448 ILE A CD1 1 ATOM 3464 N N . ILE A 1 448 ? -17.678 -0.203 -29.549 1.00 55.09 ? 449 ILE A N 1 ATOM 3465 C CA . ILE A 1 448 ? -16.643 0.271 -28.667 1.00 58.37 ? 449 ILE A CA 1 ATOM 3466 C C . ILE A 1 448 ? -16.153 -0.824 -27.735 1.00 65.67 ? 449 ILE A C 1 ATOM 3467 O O . ILE A 1 448 ? -16.777 -1.120 -26.714 1.00 74.17 ? 449 ILE A O 1 ATOM 3468 C CB . ILE A 1 448 ? -17.084 1.511 -27.899 1.00 52.70 ? 449 ILE A CB 1 ATOM 3469 C CG1 . ILE A 1 448 ? -17.780 2.477 -28.897 1.00 49.40 ? 449 ILE A CG1 1 ATOM 3470 C CG2 . ILE A 1 448 ? -15.884 2.048 -27.112 1.00 44.53 ? 449 ILE A CG2 1 ATOM 3471 C CD1 . ILE A 1 448 ? -18.316 3.765 -28.318 1.00 45.39 ? 449 ILE A CD1 1 ATOM 3472 N N . ILE A 1 449 ? -15.033 -1.428 -28.121 1.00 66.94 ? 450 ILE A N 1 ATOM 3473 C CA . ILE A 1 449 ? -14.336 -2.371 -27.271 1.00 64.00 ? 450 ILE A CA 1 ATOM 3474 C C . ILE A 1 449 ? -13.440 -1.571 -26.380 1.00 68.76 ? 450 ILE A C 1 ATOM 3475 O O . ILE A 1 449 ? -12.903 -0.545 -26.796 1.00 76.56 ? 450 ILE A O 1 ATOM 3476 C CB . ILE A 1 449 ? -13.474 -3.363 -28.074 1.00 60.57 ? 450 ILE A CB 1 ATOM 3477 C CG1 . ILE A 1 449 ? -14.316 -4.055 -29.162 1.00 57.21 ? 450 ILE A CG1 1 ATOM 3478 C CG2 . ILE A 1 449 ? -12.778 -4.374 -27.151 1.00 54.94 ? 450 ILE A CG2 1 ATOM 3479 C CD1 . ILE A 1 449 ? -15.146 -5.230 -28.700 1.00 57.64 ? 450 ILE A CD1 1 ATOM 3480 N N . HIS A 1 450 ? -13.307 -2.047 -25.147 1.00 74.69 ? 451 HIS A N 1 ATOM 3481 C CA . HIS A 1 450 ? -12.340 -1.527 -24.204 1.00 84.93 ? 451 HIS A CA 1 ATOM 3482 C C . HIS A 1 450 ? -10.932 -1.717 -24.783 1.00 91.59 ? 451 HIS A C 1 ATOM 3483 O O . HIS A 1 450 ? -10.571 -2.828 -25.193 1.00 97.62 ? 451 HIS A O 1 ATOM 3484 C CB . HIS A 1 450 ? -12.501 -2.261 -22.856 1.00 84.28 ? 451 HIS A CB 1 ATOM 3485 C CG . HIS A 1 450 ? -11.846 -1.570 -21.692 1.00 88.84 ? 451 HIS A CG 1 ATOM 3486 N ND1 . HIS A 1 450 ? -10.960 -2.208 -20.849 1.00 94.04 ? 451 HIS A ND1 1 ATOM 3487 C CD2 . HIS A 1 450 ? -11.948 -0.299 -21.232 1.00 88.91 ? 451 HIS A CD2 1 ATOM 3488 C CE1 . HIS A 1 450 ? -10.542 -1.358 -19.928 1.00 92.31 ? 451 HIS A CE1 1 ATOM 3489 N NE2 . HIS A 1 450 ? -11.130 -0.193 -20.136 1.00 87.75 ? 451 HIS A NE2 1 ATOM 3490 N N . ASP A 1 451 ? -10.163 -0.628 -24.865 1.00 91.40 ? 452 ASP A N 1 ATOM 3491 C CA . ASP A 1 451 ? -8.703 -0.734 -24.985 1.00 95.30 ? 452 ASP A CA 1 ATOM 3492 C C . ASP A 1 451 ? -8.214 -1.461 -23.722 1.00 98.60 ? 452 ASP A C 1 ATOM 3493 O O . ASP A 1 451 ? -8.807 -1.307 -22.653 1.00 121.50 ? 452 ASP A O 1 ATOM 3494 C CB . ASP A 1 451 ? -8.065 0.649 -25.053 1.00 99.17 ? 452 ASP A CB 1 ATOM 3495 C CG . ASP A 1 451 ? -8.054 1.349 -23.694 1.00 121.22 ? 452 ASP A CG 1 ATOM 3496 O OD1 . ASP A 1 451 ? -9.115 1.878 -23.278 1.00 133.04 ? 452 ASP A OD1 1 ATOM 3497 O OD2 . ASP A 1 451 ? -6.997 1.324 -23.020 1.00 116.70 ? 452 ASP A OD2 1 ATOM 3498 N N . GLN A 1 452 ? -7.132 -2.222 -23.836 1.00 93.48 ? 453 GLN A N 1 ATOM 3499 C CA . GLN A 1 452 ? -6.628 -3.124 -22.768 1.00 91.83 ? 453 GLN A CA 1 ATOM 3500 C C . GLN A 1 452 ? -7.291 -4.508 -22.767 1.00 92.22 ? 453 GLN A C 1 ATOM 3501 O O . GLN A 1 452 ? -6.831 -5.414 -22.046 1.00 94.05 ? 453 GLN A O 1 ATOM 3502 C CB . GLN A 1 452 ? -6.648 -2.494 -21.363 1.00 89.11 ? 453 GLN A CB 1 ATOM 3503 C CG . GLN A 1 452 ? -5.692 -1.323 -21.208 1.00 100.58 ? 453 GLN A CG 1 ATOM 3504 C CD . GLN A 1 452 ? -5.892 -0.552 -19.917 1.00 109.54 ? 453 GLN A CD 1 ATOM 3505 O OE1 . GLN A 1 452 ? -5.966 -1.130 -18.831 1.00 120.90 ? 453 GLN A OE1 1 ATOM 3506 N NE2 . GLN A 1 452 ? -5.966 0.768 -20.030 1.00 112.61 ? 453 GLN A NE2 1 ATOM 3507 N N . TYR A 1 453 ? -8.345 -4.680 -23.576 1.00 79.66 ? 454 TYR A N 1 ATOM 3508 C CA . TYR A 1 453 ? -8.909 -6.002 -23.784 1.00 71.77 ? 454 TYR A CA 1 ATOM 3509 C C . TYR A 1 453 ? -7.993 -6.829 -24.670 1.00 75.26 ? 454 TYR A C 1 ATOM 3510 O O . TYR A 1 453 ? -7.619 -6.377 -25.758 1.00 71.96 ? 454 TYR A O 1 ATOM 3511 C CB . TYR A 1 453 ? -10.288 -5.941 -24.428 1.00 65.36 ? 454 TYR A CB 1 ATOM 3512 C CG . TYR A 1 453 ? -10.796 -7.319 -24.796 1.00 62.30 ? 454 TYR A CG 1 ATOM 3513 C CD1 . TYR A 1 453 ? -11.048 -8.276 -23.810 1.00 61.09 ? 454 TYR A CD1 1 ATOM 3514 C CD2 . TYR A 1 453 ? -10.991 -7.686 -26.134 1.00 66.23 ? 454 TYR A CD2 1 ATOM 3515 C CE1 . TYR A 1 453 ? -11.494 -9.545 -24.141 1.00 59.07 ? 454 TYR A CE1 1 ATOM 3516 C CE2 . TYR A 1 453 ? -11.455 -8.959 -26.478 1.00 60.33 ? 454 TYR A CE2 1 ATOM 3517 C CZ . TYR A 1 453 ? -11.703 -9.872 -25.470 1.00 59.58 ? 454 TYR A CZ 1 ATOM 3518 O OH . TYR A 1 453 ? -12.130 -11.125 -25.774 1.00 64.48 ? 454 TYR A OH 1 ATOM 3519 N N . LYS A 1 454 ? -7.645 -8.030 -24.199 1.00 76.43 ? 455 LYS A N 1 ATOM 3520 C CA . LYS A 1 454 ? -6.929 -9.013 -25.026 1.00 74.72 ? 455 LYS A CA 1 ATOM 3521 C C . LYS A 1 454 ? -7.655 -10.329 -24.985 1.00 76.45 ? 455 LYS A C 1 ATOM 3522 O O . LYS A 1 454 ? -8.038 -10.851 -26.022 1.00 83.52 ? 455 LYS A O 1 ATOM 3523 C CB . LYS A 1 454 ? -5.473 -9.249 -24.583 1.00 78.14 ? 455 LYS A CB 1 ATOM 3524 C CG . LYS A 1 454 ? -4.657 -8.041 -24.129 1.00 82.98 ? 455 LYS A CG 1 ATOM 3525 C CD . LYS A 1 454 ? -4.301 -7.074 -25.248 1.00 82.13 ? 455 LYS A CD 1 ATOM 3526 C CE . LYS A 1 454 ? -3.199 -6.141 -24.773 1.00 91.95 ? 455 LYS A CE 1 ATOM 3527 N NZ . LYS A 1 454 ? -3.105 -4.882 -25.566 1.00 97.00 ? 455 LYS A NZ 1 ATOM 3528 N N . MET A 1 455 ? -7.835 -10.872 -23.789 1.00 79.28 ? 456 MET A N 1 ATOM 3529 C CA . MET A 1 455 ? -8.480 -12.165 -23.638 1.00 87.30 ? 456 MET A CA 1 ATOM 3530 C C . MET A 1 455 ? -9.557 -12.049 -22.570 1.00 87.11 ? 456 MET A C 1 ATOM 3531 O O . MET A 1 455 ? -9.406 -11.266 -21.631 1.00 87.23 ? 456 MET A O 1 ATOM 3532 C CB . MET A 1 455 ? -7.434 -13.235 -23.290 1.00 96.20 ? 456 MET A CB 1 ATOM 3533 C CG . MET A 1 455 ? -7.847 -14.671 -23.575 1.00 110.83 ? 456 MET A CG 1 ATOM 3534 S SD . MET A 1 455 ? -8.676 -14.912 -25.168 1.00 154.73 ? 456 MET A SD 1 ATOM 3535 C CE . MET A 1 455 ? -10.376 -15.289 -24.713 1.00 129.02 ? 456 MET A CE 1 ATOM 3536 N N . ALA A 1 456 ? -10.645 -12.807 -22.727 1.00 86.40 ? 457 ALA A N 1 ATOM 3537 C CA . ALA A 1 456 ? -11.770 -12.822 -21.763 1.00 88.49 ? 457 ALA A CA 1 ATOM 3538 C C . ALA A 1 456 ? -11.347 -13.092 -20.315 1.00 89.92 ? 457 ALA A C 1 ATOM 3539 O O . ALA A 1 456 ? -11.912 -12.526 -19.369 1.00 99.09 ? 457 ALA A O 1 ATOM 3540 C CB . ALA A 1 456 ? -12.827 -13.827 -22.191 1.00 83.95 ? 457 ALA A CB 1 ATOM 3541 N N . GLU A 1 457 ? -10.345 -13.956 -20.167 1.00 94.46 ? 458 GLU A N 1 ATOM 3542 C CA . GLU A 1 457 ? -9.819 -14.370 -18.872 1.00 85.43 ? 458 GLU A CA 1 ATOM 3543 C C . GLU A 1 457 ? -8.801 -13.369 -18.355 1.00 83.50 ? 458 GLU A C 1 ATOM 3544 O O . GLU A 1 457 ? -8.507 -13.370 -17.174 1.00 89.63 ? 458 GLU A O 1 ATOM 3545 C CB . GLU A 1 457 ? -9.202 -15.774 -18.937 1.00 85.45 ? 458 GLU A CB 1 ATOM 3546 C CG . GLU A 1 457 ? -10.140 -16.915 -19.333 1.00 83.85 ? 458 GLU A CG 1 ATOM 3547 C CD . GLU A 1 457 ? -10.265 -17.145 -20.842 1.00 90.20 ? 458 GLU A CD 1 ATOM 3548 O OE1 . GLU A 1 457 ? -9.579 -16.484 -21.656 1.00 92.96 ? 458 GLU A OE1 1 ATOM 3549 O OE2 . GLU A 1 457 ? -11.071 -18.014 -21.226 1.00 100.15 ? 458 GLU A OE2 1 ATOM 3550 N N . SER A 1 458 ? -8.264 -12.524 -19.236 1.00 79.66 ? 459 SER A N 1 ATOM 3551 C CA . SER A 1 458 ? -7.500 -11.348 -18.805 1.00 87.04 ? 459 SER A CA 1 ATOM 3552 C C . SER A 1 458 ? -8.409 -10.276 -18.169 1.00 96.85 ? 459 SER A C 1 ATOM 3553 O O . SER A 1 458 ? -7.918 -9.384 -17.474 1.00 101.87 ? 459 SER A O 1 ATOM 3554 C CB . SER A 1 458 ? -6.670 -10.760 -19.959 1.00 95.94 ? 459 SER A CB 1 ATOM 3555 O OG . SER A 1 458 ? -7.399 -9.800 -20.746 1.00 102.59 ? 459 SER A OG 1 ATOM 3556 N N . GLY A 1 459 ? -9.715 -10.342 -18.453 1.00 100.03 ? 460 GLY A N 1 ATOM 3557 C CA . GLY A 1 459 ? -10.735 -9.630 -17.676 1.00 100.51 ? 460 GLY A CA 1 ATOM 3558 C C . GLY A 1 459 ? -11.330 -8.289 -18.102 1.00 100.02 ? 460 GLY A C 1 ATOM 3559 O O . GLY A 1 459 ? -12.480 -7.981 -17.717 1.00 113.67 ? 460 GLY A O 1 ATOM 3560 N N . TYR A 1 460 ? -10.582 -7.489 -18.868 1.00 78.62 ? 461 TYR A N 1 ATOM 3561 C CA . TYR A 1 460 ? -11.026 -6.133 -19.246 1.00 73.56 ? 461 TYR A CA 1 ATOM 3562 C C . TYR A 1 460 ? -12.072 -6.183 -20.384 1.00 70.67 ? 461 TYR A C 1 ATOM 3563 O O . TYR A 1 460 ? -12.007 -5.430 -21.359 1.00 74.56 ? 461 TYR A O 1 ATOM 3564 C CB . TYR A 1 460 ? -9.812 -5.223 -19.536 1.00 81.87 ? 461 TYR A CB 1 ATOM 3565 C CG . TYR A 1 460 ? -9.097 -4.706 -18.287 1.00 98.84 ? 461 TYR A CG 1 ATOM 3566 C CD1 . TYR A 1 460 ? -8.834 -3.334 -18.128 1.00 102.05 ? 461 TYR A CD1 1 ATOM 3567 C CD2 . TYR A 1 460 ? -8.698 -5.583 -17.246 1.00 110.48 ? 461 TYR A CD2 1 ATOM 3568 C CE1 . TYR A 1 460 ? -8.204 -2.842 -16.982 1.00 113.71 ? 461 TYR A CE1 1 ATOM 3569 C CE2 . TYR A 1 460 ? -8.074 -5.101 -16.091 1.00 123.18 ? 461 TYR A CE2 1 ATOM 3570 C CZ . TYR A 1 460 ? -7.824 -3.730 -15.967 1.00 126.32 ? 461 TYR A CZ 1 ATOM 3571 O OH . TYR A 1 460 ? -7.202 -3.237 -14.839 1.00 135.33 ? 461 TYR A OH 1 ATOM 3572 N N . ASP A 1 461 ? -13.074 -7.042 -20.175 1.00 63.69 ? 462 ASP A N 1 ATOM 3573 C CA . ASP A 1 461 ? -13.960 -7.619 -21.190 1.00 59.76 ? 462 ASP A CA 1 ATOM 3574 C C . ASP A 1 461 ? -15.362 -6.986 -21.252 1.00 65.25 ? 462 ASP A C 1 ATOM 3575 O O . ASP A 1 461 ? -16.351 -7.530 -20.698 1.00 60.12 ? 462 ASP A O 1 ATOM 3576 C CB . ASP A 1 461 ? -14.093 -9.134 -20.923 1.00 53.32 ? 462 ASP A CB 1 ATOM 3577 C CG . ASP A 1 461 ? -14.923 -9.871 -21.991 1.00 53.49 ? 462 ASP A CG 1 ATOM 3578 O OD1 . ASP A 1 461 ? -15.122 -9.349 -23.127 1.00 51.46 ? 462 ASP A OD1 1 ATOM 3579 O OD2 . ASP A 1 461 ? -15.382 -10.996 -21.689 1.00 50.69 ? 462 ASP A OD2 1 ATOM 3580 N N . ILE A 1 462 ? -15.450 -5.874 -21.978 1.00 62.39 ? 463 ILE A N 1 ATOM 3581 C CA . ILE A 1 462 ? -16.663 -5.075 -22.006 1.00 57.28 ? 463 ILE A CA 1 ATOM 3582 C C . ILE A 1 462 ? -16.828 -4.319 -23.328 1.00 55.85 ? 463 ILE A C 1 ATOM 3583 O O . ILE A 1 462 ? -15.920 -3.633 -23.788 1.00 54.55 ? 463 ILE A O 1 ATOM 3584 C CB . ILE A 1 462 ? -16.684 -4.100 -20.796 1.00 58.75 ? 463 ILE A CB 1 ATOM 3585 C CG1 . ILE A 1 462 ? -18.055 -3.423 -20.656 1.00 64.99 ? 463 ILE A CG1 1 ATOM 3586 C CG2 . ILE A 1 462 ? -15.538 -3.098 -20.867 1.00 55.95 ? 463 ILE A CG2 1 ATOM 3587 C CD1 . ILE A 1 462 ? -18.303 -2.677 -19.355 1.00 64.98 ? 463 ILE A CD1 1 ATOM 3588 N N . ALA A 1 463 ? -18.006 -4.433 -23.921 1.00 58.01 ? 464 ALA A N 1 ATOM 3589 C CA . ALA A 1 463 ? -18.309 -3.749 -25.175 1.00 59.68 ? 464 ALA A CA 1 ATOM 3590 C C . ALA A 1 463 ? -19.593 -2.913 -25.152 1.00 59.02 ? 464 ALA A C 1 ATOM 3591 O O . ALA A 1 463 ? -20.554 -3.227 -24.432 1.00 58.25 ? 464 ALA A O 1 ATOM 3592 C CB . ALA A 1 463 ? -18.355 -4.754 -26.313 1.00 61.37 ? 464 ALA A CB 1 ATOM 3593 N N . LEU A 1 464 ? -19.579 -1.846 -25.953 1.00 58.74 ? 465 LEU A N 1 ATOM 3594 C CA . LEU A 1 464 ? -20.758 -1.034 -26.231 1.00 56.76 ? 465 LEU A CA 1 ATOM 3595 C C . LEU A 1 464 ? -21.173 -1.042 -27.692 1.00 53.52 ? 465 LEU A C 1 ATOM 3596 O O . LEU A 1 464 ? -20.350 -0.956 -28.591 1.00 52.41 ? 465 LEU A O 1 ATOM 3597 C CB . LEU A 1 464 ? -20.525 0.402 -25.806 1.00 62.77 ? 465 LEU A CB 1 ATOM 3598 C CG . LEU A 1 464 ? -20.718 0.718 -24.332 1.00 70.10 ? 465 LEU A CG 1 ATOM 3599 C CD1 . LEU A 1 464 ? -20.056 2.047 -23.967 1.00 73.41 ? 465 LEU A CD1 1 ATOM 3600 C CD2 . LEU A 1 464 ? -22.205 0.727 -23.996 1.00 70.40 ? 465 LEU A CD2 1 ATOM 3601 N N . LEU A 1 465 ? -22.468 -1.136 -27.917 1.00 52.82 ? 466 LEU A N 1 ATOM 3602 C CA . LEU A 1 465 ? -23.014 -0.966 -29.242 1.00 55.44 ? 466 LEU A CA 1 ATOM 3603 C C . LEU A 1 465 ? -23.752 0.351 -29.220 1.00 61.30 ? 466 LEU A C 1 ATOM 3604 O O . LEU A 1 465 ? -24.604 0.560 -28.367 1.00 68.41 ? 466 LEU A O 1 ATOM 3605 C CB . LEU A 1 465 ? -23.955 -2.115 -29.623 1.00 52.51 ? 466 LEU A CB 1 ATOM 3606 C CG . LEU A 1 465 ? -23.540 -3.573 -29.317 1.00 57.82 ? 466 LEU A CG 1 ATOM 3607 C CD1 . LEU A 1 465 ? -24.397 -4.627 -30.041 1.00 47.43 ? 466 LEU A CD1 1 ATOM 3608 C CD2 . LEU A 1 465 ? -22.053 -3.809 -29.595 1.00 63.55 ? 466 LEU A CD2 1 ATOM 3609 N N . LYS A 1 466 ? -23.355 1.263 -30.108 1.00 66.43 ? 467 LYS A N 1 ATOM 3610 C CA . LYS A 1 466 ? -24.115 2.466 -30.423 1.00 65.69 ? 467 LYS A CA 1 ATOM 3611 C C . LYS A 1 466 ? -25.026 2.013 -31.523 1.00 65.11 ? 467 LYS A C 1 ATOM 3612 O O . LYS A 1 466 ? -24.548 1.583 -32.567 1.00 70.24 ? 467 LYS A O 1 ATOM 3613 C CB . LYS A 1 466 ? -23.181 3.579 -30.907 1.00 67.67 ? 467 LYS A CB 1 ATOM 3614 C CG . LYS A 1 466 ? -23.855 4.897 -31.278 1.00 75.66 ? 467 LYS A CG 1 ATOM 3615 C CD . LYS A 1 466 ? -22.824 6.021 -31.327 1.00 75.75 ? 467 LYS A CD 1 ATOM 3616 C CE . LYS A 1 466 ? -23.481 7.392 -31.228 1.00 79.40 ? 467 LYS A CE 1 ATOM 3617 N NZ . LYS A 1 466 ? -22.722 8.318 -30.330 1.00 81.62 ? 467 LYS A NZ 1 ATOM 3618 N N . LEU A 1 467 ? -26.328 2.038 -31.277 1.00 67.55 ? 468 LEU A N 1 ATOM 3619 C CA . LEU A 1 467 ? -27.291 1.680 -32.305 1.00 71.09 ? 468 LEU A CA 1 ATOM 3620 C C . LEU A 1 467 ? -27.493 2.860 -33.229 1.00 86.69 ? 468 LEU A C 1 ATOM 3621 O O . LEU A 1 467 ? -27.488 4.013 -32.771 1.00 103.28 ? 468 LEU A O 1 ATOM 3622 C CB . LEU A 1 467 ? -28.606 1.336 -31.671 1.00 73.40 ? 468 LEU A CB 1 ATOM 3623 C CG . LEU A 1 467 ? -28.593 0.417 -30.467 1.00 78.76 ? 468 LEU A CG 1 ATOM 3624 C CD1 . LEU A 1 467 ? -30.019 0.370 -29.953 1.00 83.48 ? 468 LEU A CD1 1 ATOM 3625 C CD2 . LEU A 1 467 ? -28.088 -0.977 -30.817 1.00 78.68 ? 468 LEU A CD2 1 ATOM 3626 N N . GLU A 1 468 ? -27.671 2.590 -34.523 1.00 93.59 ? 469 GLU A N 1 ATOM 3627 C CA . GLU A 1 468 ? -27.807 3.676 -35.506 1.00 103.79 ? 469 GLU A CA 1 ATOM 3628 C C . GLU A 1 468 ? -29.199 4.352 -35.502 1.00 100.13 ? 469 GLU A C 1 ATOM 3629 O O . GLU A 1 468 ? -29.382 5.378 -36.144 1.00 98.43 ? 469 GLU A O 1 ATOM 3630 C CB . GLU A 1 468 ? -27.362 3.242 -36.916 1.00 112.92 ? 469 GLU A CB 1 ATOM 3631 C CG . GLU A 1 468 ? -28.371 2.406 -37.694 1.00 128.04 ? 469 GLU A CG 1 ATOM 3632 C CD . GLU A 1 468 ? -27.902 2.057 -39.097 1.00 140.98 ? 469 GLU A CD 1 ATOM 3633 O OE1 . GLU A 1 468 ? -27.345 2.941 -39.796 1.00 143.05 ? 469 GLU A OE1 1 ATOM 3634 O OE2 . GLU A 1 468 ? -28.114 0.893 -39.506 1.00 140.36 ? 469 GLU A OE2 1 ATOM 3635 N N . THR A 1 469 ? -30.167 3.764 -34.794 1.00 89.76 ? 470 THR A N 1 ATOM 3636 C CA . THR A 1 469 ? -31.477 4.384 -34.559 1.00 84.53 ? 470 THR A CA 1 ATOM 3637 C C . THR A 1 469 ? -31.937 4.096 -33.113 1.00 88.35 ? 470 THR A C 1 ATOM 3638 O O . THR A 1 469 ? -31.733 2.984 -32.618 1.00 85.85 ? 470 THR A O 1 ATOM 3639 C CB . THR A 1 469 ? -32.561 3.898 -35.561 1.00 86.00 ? 470 THR A CB 1 ATOM 3640 O OG1 . THR A 1 469 ? -33.283 2.787 -35.011 1.00 88.87 ? 470 THR A OG1 1 ATOM 3641 C CG2 . THR A 1 469 ? -31.982 3.508 -36.946 1.00 82.68 ? 470 THR A CG2 1 ATOM 3642 N N . THR A 1 470 ? -32.576 5.075 -32.460 1.00 92.57 ? 471 THR A N 1 ATOM 3643 C CA . THR A 1 470 ? -32.913 5.000 -31.006 1.00 89.58 ? 471 THR A CA 1 ATOM 3644 C C . THR A 1 470 ? -34.125 4.098 -30.723 1.00 83.88 ? 471 THR A C 1 ATOM 3645 O O . THR A 1 470 ? -34.834 3.732 -31.655 1.00 84.87 ? 471 THR A O 1 ATOM 3646 C CB . THR A 1 470 ? -33.133 6.399 -30.382 1.00 87.08 ? 471 THR A CB 1 ATOM 3647 O OG1 . THR A 1 470 ? -34.154 7.080 -31.117 1.00 91.90 ? 471 THR A OG1 1 ATOM 3648 C CG2 . THR A 1 470 ? -31.829 7.249 -30.376 1.00 77.96 ? 471 THR A CG2 1 ATOM 3649 N N . VAL A 1 471 ? -34.346 3.736 -29.452 1.00 82.85 ? 472 VAL A N 1 ATOM 3650 C CA . VAL A 1 471 ? -35.394 2.763 -29.054 1.00 86.06 ? 472 VAL A CA 1 ATOM 3651 C C . VAL A 1 471 ? -36.669 3.449 -28.542 1.00 94.83 ? 472 VAL A C 1 ATOM 3652 O O . VAL A 1 471 ? -36.618 4.196 -27.556 1.00 100.06 ? 472 VAL A O 1 ATOM 3653 C CB . VAL A 1 471 ? -34.893 1.798 -27.941 1.00 77.80 ? 472 VAL A CB 1 ATOM 3654 C CG1 . VAL A 1 471 ? -35.950 0.765 -27.577 1.00 80.56 ? 472 VAL A CG1 1 ATOM 3655 C CG2 . VAL A 1 471 ? -33.634 1.083 -28.360 1.00 73.85 ? 472 VAL A CG2 1 ATOM 3656 N N . ASN A 1 472 ? -37.806 3.187 -29.190 1.00 96.52 ? 473 ASN A N 1 ATOM 3657 C CA . ASN A 1 472 ? -39.103 3.628 -28.659 1.00 106.75 ? 473 ASN A CA 1 ATOM 3658 C C . ASN A 1 472 ? -39.353 2.749 -27.421 1.00 101.82 ? 473 ASN A C 1 ATOM 3659 O O . ASN A 1 472 ? -39.653 1.565 -27.569 1.00 99.66 ? 473 ASN A O 1 ATOM 3660 C CB . ASN A 1 472 ? -40.219 3.477 -29.733 1.00 116.87 ? 473 ASN A CB 1 ATOM 3661 C CG . ASN A 1 472 ? -41.322 4.552 -29.649 1.00 118.13 ? 473 ASN A CG 1 ATOM 3662 O OD1 . ASN A 1 472 ? -42.516 4.243 -29.769 1.00 118.87 ? 473 ASN A OD1 1 ATOM 3663 N ND2 . ASN A 1 472 ? -40.926 5.810 -29.481 1.00 119.18 ? 473 ASN A ND2 1 ATOM 3664 N N . TYR A 1 473 ? -39.166 3.305 -26.214 1.00 91.63 ? 474 TYR A N 1 ATOM 3665 C CA . TYR A 1 473 ? -39.314 2.528 -24.970 1.00 87.28 ? 474 TYR A CA 1 ATOM 3666 C C . TYR A 1 473 ? -40.716 1.988 -24.785 1.00 85.44 ? 474 TYR A C 1 ATOM 3667 O O . TYR A 1 473 ? -41.686 2.731 -24.885 1.00 96.33 ? 474 TYR A O 1 ATOM 3668 C CB . TYR A 1 473 ? -38.962 3.342 -23.730 1.00 91.40 ? 474 TYR A CB 1 ATOM 3669 C CG . TYR A 1 473 ? -37.495 3.554 -23.452 1.00 92.39 ? 474 TYR A CG 1 ATOM 3670 C CD1 . TYR A 1 473 ? -36.561 2.517 -23.599 1.00 92.10 ? 474 TYR A CD1 1 ATOM 3671 C CD2 . TYR A 1 473 ? -37.045 4.791 -22.992 1.00 90.09 ? 474 TYR A CD2 1 ATOM 3672 C CE1 . TYR A 1 473 ? -35.216 2.730 -23.342 1.00 94.79 ? 474 TYR A CE1 1 ATOM 3673 C CE2 . TYR A 1 473 ? -35.707 5.010 -22.716 1.00 98.00 ? 474 TYR A CE2 1 ATOM 3674 C CZ . TYR A 1 473 ? -34.796 3.981 -22.894 1.00 97.89 ? 474 TYR A CZ 1 ATOM 3675 O OH . TYR A 1 473 ? -33.471 4.207 -22.616 1.00 101.41 ? 474 TYR A OH 1 ATOM 3676 N N . THR A 1 474 ? -40.814 0.688 -24.539 1.00 78.47 ? 475 THR A N 1 ATOM 3677 C CA . THR A 1 474 ? -42.090 0.054 -24.256 1.00 79.89 ? 475 THR A CA 1 ATOM 3678 C C . THR A 1 474 ? -41.995 -0.972 -23.113 1.00 91.62 ? 475 THR A C 1 ATOM 3679 O O . THR A 1 474 ? -40.943 -1.155 -22.488 1.00 90.73 ? 475 THR A O 1 ATOM 3680 C CB . THR A 1 474 ? -42.724 -0.623 -25.495 1.00 78.41 ? 475 THR A CB 1 ATOM 3681 O OG1 . THR A 1 474 ? -42.327 -2.005 -25.563 1.00 86.08 ? 475 THR A OG1 1 ATOM 3682 C CG2 . THR A 1 474 ? -42.391 0.101 -26.791 1.00 75.23 ? 475 THR A CG2 1 ATOM 3683 N N . ASP A 1 475 ? -43.124 -1.633 -22.857 1.00 103.23 ? 476 ASP A N 1 ATOM 3684 C CA . ASP A 1 475 ? -43.253 -2.654 -21.827 1.00 105.69 ? 476 ASP A CA 1 ATOM 3685 C C . ASP A 1 475 ? -42.403 -3.843 -22.218 1.00 98.88 ? 476 ASP A C 1 ATOM 3686 O O . ASP A 1 475 ? -42.018 -4.659 -21.370 1.00 97.28 ? 476 ASP A O 1 ATOM 3687 C CB . ASP A 1 475 ? -44.725 -3.074 -21.675 1.00 119.34 ? 476 ASP A CB 1 ATOM 3688 C CG . ASP A 1 475 ? -45.459 -2.307 -20.570 1.00 121.44 ? 476 ASP A CG 1 ATOM 3689 O OD1 . ASP A 1 475 ? -45.462 -1.045 -20.572 1.00 122.74 ? 476 ASP A OD1 1 ATOM 3690 O OD2 . ASP A 1 475 ? -46.054 -2.985 -19.693 1.00 123.00 ? 476 ASP A OD2 1 ATOM 3691 N N . SER A 1 476 ? -42.107 -3.918 -23.510 1.00 85.37 ? 477 SER A N 1 ATOM 3692 C CA . SER A 1 476 ? -41.200 -4.922 -24.027 1.00 89.76 ? 477 SER A CA 1 ATOM 3693 C C . SER A 1 476 ? -39.742 -4.449 -24.212 1.00 90.10 ? 477 SER A C 1 ATOM 3694 O O . SER A 1 476 ? -38.853 -5.280 -24.421 1.00 97.09 ? 477 SER A O 1 ATOM 3695 C CB . SER A 1 476 ? -41.772 -5.463 -25.316 1.00 84.25 ? 477 SER A CB 1 ATOM 3696 O OG . SER A 1 476 ? -43.077 -5.899 -25.048 1.00 85.84 ? 477 SER A OG 1 ATOM 3697 N N . GLN A 1 477 ? -39.505 -3.133 -24.124 1.00 80.58 ? 478 GLN A N 1 ATOM 3698 C CA . GLN A 1 477 ? -38.209 -2.527 -24.440 1.00 79.59 ? 478 GLN A CA 1 ATOM 3699 C C . GLN A 1 477 ? -37.867 -1.339 -23.522 1.00 97.02 ? 478 GLN A C 1 ATOM 3700 O O . GLN A 1 477 ? -38.069 -0.176 -23.900 1.00 106.26 ? 478 GLN A O 1 ATOM 3701 C CB . GLN A 1 477 ? -38.173 -2.035 -25.894 1.00 79.09 ? 478 GLN A CB 1 ATOM 3702 C CG . GLN A 1 477 ? -39.001 -2.801 -26.922 1.00 85.22 ? 478 GLN A CG 1 ATOM 3703 C CD . GLN A 1 477 ? -39.012 -2.128 -28.284 1.00 88.06 ? 478 GLN A CD 1 ATOM 3704 O OE1 . GLN A 1 477 ? -39.100 -0.909 -28.390 1.00 90.47 ? 478 GLN A OE1 1 ATOM 3705 N NE2 . GLN A 1 477 ? -38.918 -2.926 -29.334 1.00 90.69 ? 478 GLN A NE2 1 ATOM 3706 N N . ARG A 1 478 ? -37.333 -1.627 -22.332 1.00 101.28 ? 479 ARG A N 1 ATOM 3707 C CA . ARG A 1 478 ? -36.997 -0.597 -21.323 1.00 96.23 ? 479 ARG A CA 1 ATOM 3708 C C . ARG A 1 478 ? -35.531 -0.852 -20.871 1.00 80.71 ? 479 ARG A C 1 ATOM 3709 O O . ARG A 1 478 ? -35.078 -1.993 -20.969 1.00 82.09 ? 479 ARG A O 1 ATOM 3710 C CB . ARG A 1 478 ? -38.010 -0.705 -20.156 1.00 100.05 ? 479 ARG A CB 1 ATOM 3711 C CG . ARG A 1 478 ? -38.444 0.600 -19.473 1.00 98.96 ? 479 ARG A CG 1 ATOM 3712 C CD . ARG A 1 478 ? -38.677 0.373 -17.979 1.00 105.97 ? 479 ARG A CD 1 ATOM 3713 N NE . ARG A 1 478 ? -37.528 -0.266 -17.294 1.00 108.39 ? 479 ARG A NE 1 ATOM 3714 C CZ . ARG A 1 478 ? -37.597 -1.268 -16.406 1.00 98.86 ? 479 ARG A CZ 1 ATOM 3715 N NH1 . ARG A 1 478 ? -38.763 -1.797 -16.051 1.00 95.71 ? 479 ARG A NH1 1 ATOM 3716 N NH2 . ARG A 1 478 ? -36.483 -1.760 -15.874 1.00 92.04 ? 479 ARG A NH2 1 ATOM 3717 N N . PRO A 1 479 ? -34.774 0.184 -20.412 1.00 67.10 ? 480 PRO A N 1 ATOM 3718 C CA . PRO A 1 479 ? -33.404 -0.144 -19.937 1.00 63.87 ? 480 PRO A CA 1 ATOM 3719 C C . PRO A 1 479 ? -33.333 -0.755 -18.534 1.00 64.23 ? 480 PRO A C 1 ATOM 3720 O O . PRO A 1 479 ? -34.310 -0.710 -17.778 1.00 73.76 ? 480 PRO A O 1 ATOM 3721 C CB . PRO A 1 479 ? -32.674 1.201 -19.952 1.00 58.26 ? 480 PRO A CB 1 ATOM 3722 C CG . PRO A 1 479 ? -33.747 2.222 -19.857 1.00 64.29 ? 480 PRO A CG 1 ATOM 3723 C CD . PRO A 1 479 ? -35.061 1.623 -20.295 1.00 62.22 ? 480 PRO A CD 1 ATOM 3724 N N . ILE A 1 480 ? -32.184 -1.349 -18.228 1.00 58.81 ? 481 ILE A N 1 ATOM 3725 C CA . ILE A 1 480 ? -31.769 -1.728 -16.875 1.00 60.23 ? 481 ILE A CA 1 ATOM 3726 C C . ILE A 1 480 ? -30.863 -0.592 -16.344 1.00 61.67 ? 481 ILE A C 1 ATOM 3727 O O . ILE A 1 480 ? -30.444 0.257 -17.134 1.00 75.38 ? 481 ILE A O 1 ATOM 3728 C CB . ILE A 1 480 ? -31.050 -3.095 -16.908 1.00 61.61 ? 481 ILE A CB 1 ATOM 3729 C CG1 . ILE A 1 480 ? -30.915 -3.704 -15.514 1.00 67.79 ? 481 ILE A CG1 1 ATOM 3730 C CG2 . ILE A 1 480 ? -29.698 -3.001 -17.600 1.00 63.81 ? 481 ILE A CG2 1 ATOM 3731 C CD1 . ILE A 1 480 ? -30.259 -5.072 -15.506 1.00 69.50 ? 481 ILE A CD1 1 ATOM 3732 N N . CYS A 1 481 ? -30.588 -0.543 -15.035 1.00 60.47 ? 482 CYS A N 1 ATOM 3733 C CA . CYS A 1 481 ? -29.720 0.507 -14.450 1.00 62.65 ? 482 CYS A CA 1 ATOM 3734 C C . CYS A 1 481 ? -28.336 -0.001 -14.128 1.00 61.17 ? 482 CYS A C 1 ATOM 3735 O O . CYS A 1 481 ? -28.159 -1.125 -13.656 1.00 60.87 ? 482 CYS A O 1 ATOM 3736 C CB . CYS A 1 481 ? -30.257 1.101 -13.139 1.00 64.36 ? 482 CYS A CB 1 ATOM 3737 S SG . CYS A 1 481 ? -31.841 1.942 -13.125 1.00 76.92 ? 482 CYS A SG 1 ATOM 3738 N N . LEU A 1 482 ? -27.357 0.869 -14.330 1.00 59.74 ? 483 LEU A N 1 ATOM 3739 C CA . LEU A 1 482 ? -25.996 0.568 -13.928 1.00 59.13 ? 483 LEU A CA 1 ATOM 3740 C C . LEU A 1 482 ? -25.907 0.687 -12.421 1.00 58.98 ? 483 LEU A C 1 ATOM 3741 O O . LEU A 1 482 ? -26.531 1.570 -11.841 1.00 68.54 ? 483 LEU A O 1 ATOM 3742 C CB . LEU A 1 482 ? -24.987 1.486 -14.645 1.00 53.82 ? 483 LEU A CB 1 ATOM 3743 C CG . LEU A 1 482 ? -25.186 1.488 -16.163 1.00 49.77 ? 483 LEU A CG 1 ATOM 3744 C CD1 . LEU A 1 482 ? -24.264 2.448 -16.873 1.00 47.53 ? 483 LEU A CD1 1 ATOM 3745 C CD2 . LEU A 1 482 ? -25.026 0.085 -16.739 1.00 53.38 ? 483 LEU A CD2 1 ATOM 3746 N N . PRO A 1 483 ? -25.168 -0.220 -11.777 1.00 58.83 ? 484 PRO A N 1 ATOM 3747 C CA . PRO A 1 483 ? -24.853 -0.071 -10.368 1.00 64.38 ? 484 PRO A CA 1 ATOM 3748 C C . PRO A 1 483 ? -24.222 1.293 -10.102 1.00 68.74 ? 484 PRO A C 1 ATOM 3749 O O . PRO A 1 483 ? -23.561 1.845 -10.988 1.00 70.46 ? 484 PRO A O 1 ATOM 3750 C CB . PRO A 1 483 ? -23.821 -1.174 -10.127 1.00 66.00 ? 484 PRO A CB 1 ATOM 3751 C CG . PRO A 1 483 ? -23.305 -1.526 -11.492 1.00 66.52 ? 484 PRO A CG 1 ATOM 3752 C CD . PRO A 1 483 ? -24.537 -1.418 -12.333 1.00 60.83 ? 484 PRO A CD 1 ATOM 3753 N N . SER A 1 484 ? -24.462 1.836 -8.909 1.00 69.87 ? 485 SER A N 1 ATOM 3754 C CA . SER A 1 484 ? -23.867 3.102 -8.499 1.00 65.39 ? 485 SER A CA 1 ATOM 3755 C C . SER A 1 484 ? -22.558 2.868 -7.810 1.00 61.00 ? 485 SER A C 1 ATOM 3756 O O . SER A 1 484 ? -22.467 1.965 -7.006 1.00 65.55 ? 485 SER A O 1 ATOM 3757 C CB . SER A 1 484 ? -24.798 3.870 -7.563 1.00 64.27 ? 485 SER A CB 1 ATOM 3758 O OG . SER A 1 484 ? -25.657 4.700 -8.325 1.00 72.32 ? 485 SER A OG 1 ATOM 3759 N N . LYS A 1 485 ? -21.566 3.703 -8.114 1.00 59.67 ? 486 LYS A N 1 ATOM 3760 C CA . LYS A 1 485 ? -20.291 3.747 -7.394 1.00 64.38 ? 486 LYS A CA 1 ATOM 3761 C C . LYS A 1 485 ? -20.399 3.909 -5.866 1.00 69.45 ? 486 LYS A C 1 ATOM 3762 O O . LYS A 1 485 ? -19.554 3.406 -5.118 1.00 74.72 ? 486 LYS A O 1 ATOM 3763 C CB . LYS A 1 485 ? -19.431 4.881 -7.926 1.00 66.60 ? 486 LYS A CB 1 ATOM 3764 C CG . LYS A 1 485 ? -18.811 4.654 -9.287 1.00 63.64 ? 486 LYS A CG 1 ATOM 3765 C CD . LYS A 1 485 ? -18.704 5.973 -10.023 1.00 62.65 ? 486 LYS A CD 1 ATOM 3766 C CE . LYS A 1 485 ? -17.381 6.652 -9.795 1.00 58.76 ? 486 LYS A CE 1 ATOM 3767 N NZ . LYS A 1 485 ? -17.230 7.719 -10.811 1.00 64.13 ? 486 LYS A NZ 1 ATOM 3768 N N . GLY A 1 486 ? -21.417 4.622 -5.402 1.00 75.49 ? 487 GLY A N 1 ATOM 3769 C CA . GLY A 1 486 ? -21.707 4.682 -3.962 1.00 80.65 ? 487 GLY A CA 1 ATOM 3770 C C . GLY A 1 486 ? -22.051 3.347 -3.325 1.00 75.65 ? 487 GLY A C 1 ATOM 3771 O O . GLY A 1 486 ? -21.683 3.090 -2.163 1.00 73.92 ? 487 GLY A O 1 ATOM 3772 N N . ASP A 1 487 ? -22.728 2.506 -4.120 1.00 69.64 ? 488 ASP A N 1 ATOM 3773 C CA . ASP A 1 487 ? -23.176 1.157 -3.737 1.00 67.67 ? 488 ASP A CA 1 ATOM 3774 C C . ASP A 1 487 ? -22.136 0.030 -3.808 1.00 61.79 ? 488 ASP A C 1 ATOM 3775 O O . ASP A 1 487 ? -22.498 -1.143 -3.818 1.00 60.67 ? 488 ASP A O 1 ATOM 3776 C CB . ASP A 1 487 ? -24.398 0.758 -4.569 1.00 63.70 ? 488 ASP A CB 1 ATOM 3777 C CG . ASP A 1 487 ? -25.668 1.461 -4.125 1.00 66.04 ? 488 ASP A CG 1 ATOM 3778 O OD1 . ASP A 1 487 ? -26.006 1.500 -2.911 1.00 59.39 ? 488 ASP A OD1 1 ATOM 3779 O OD2 . ASP A 1 487 ? -26.349 1.976 -5.029 1.00 72.75 ? 488 ASP A OD2 1 ATOM 3780 N N . ARG A 1 488 ? -20.855 0.377 -3.832 1.00 65.96 ? 489 ARG A N 1 ATOM 3781 C CA . ARG A 1 488 ? -19.784 -0.625 -3.796 1.00 70.97 ? 489 ARG A CA 1 ATOM 3782 C C . ARG A 1 488 ? -19.922 -1.661 -2.665 1.00 72.29 ? 489 ARG A C 1 ATOM 3783 O O . ARG A 1 488 ? -19.782 -2.843 -2.926 1.00 72.85 ? 489 ARG A O 1 ATOM 3784 C CB . ARG A 1 488 ? -18.393 0.027 -3.853 1.00 73.48 ? 489 ARG A CB 1 ATOM 3785 C CG . ARG A 1 488 ? -17.933 0.255 -5.294 1.00 74.03 ? 489 ARG A CG 1 ATOM 3786 C CD . ARG A 1 488 ? -16.442 0.550 -5.413 1.00 78.99 ? 489 ARG A CD 1 ATOM 3787 N NE . ARG A 1 488 ? -16.216 1.972 -5.653 1.00 86.28 ? 489 ARG A NE 1 ATOM 3788 C CZ . ARG A 1 488 ? -16.231 2.559 -6.854 1.00 91.05 ? 489 ARG A CZ 1 ATOM 3789 N NH1 . ARG A 1 488 ? -16.446 1.841 -7.965 1.00 87.82 ? 489 ARG A NH1 1 ATOM 3790 N NH2 . ARG A 1 488 ? -16.033 3.879 -6.941 1.00 83.15 ? 489 ARG A NH2 1 ATOM 3791 N N . ASN A 1 489 ? -20.269 -1.234 -1.450 1.00 75.86 ? 490 ASN A N 1 ATOM 3792 C CA . ASN A 1 489 ? -20.482 -2.174 -0.331 1.00 76.68 ? 490 ASN A CA 1 ATOM 3793 C C . ASN A 1 489 ? -21.787 -2.977 -0.330 1.00 74.16 ? 490 ASN A C 1 ATOM 3794 O O . ASN A 1 489 ? -22.050 -3.678 0.658 1.00 73.08 ? 490 ASN A O 1 ATOM 3795 C CB . ASN A 1 489 ? -20.373 -1.453 1.015 1.00 86.73 ? 490 ASN A CB 1 ATOM 3796 C CG . ASN A 1 489 ? -19.057 -0.739 1.190 1.00 98.83 ? 490 ASN A CG 1 ATOM 3797 O OD1 . ASN A 1 489 ? -18.042 -1.143 0.618 1.00 112.16 ? 490 ASN A OD1 1 ATOM 3798 N ND2 . ASN A 1 489 ? -19.062 0.332 1.989 1.00 95.59 ? 490 ASN A ND2 1 ATOM 3799 N N . VAL A 1 490 ? -22.593 -2.881 -1.399 1.00 67.61 ? 491 VAL A N 1 ATOM 3800 C CA . VAL A 1 490 ? -23.923 -3.531 -1.428 1.00 71.32 ? 491 VAL A CA 1 ATOM 3801 C C . VAL A 1 490 ? -23.817 -5.040 -1.514 1.00 73.66 ? 491 VAL A C 1 ATOM 3802 O O . VAL A 1 490 ? -22.945 -5.576 -2.196 1.00 90.47 ? 491 VAL A O 1 ATOM 3803 C CB . VAL A 1 490 ? -24.873 -2.998 -2.543 1.00 72.86 ? 491 VAL A CB 1 ATOM 3804 C CG1 . VAL A 1 490 ? -26.084 -3.911 -2.768 1.00 65.94 ? 491 VAL A CG1 1 ATOM 3805 C CG2 . VAL A 1 490 ? -25.384 -1.620 -2.179 1.00 73.48 ? 491 VAL A CG2 1 ATOM 3806 N N . ILE A 1 491 ? -24.734 -5.702 -0.825 1.00 66.12 ? 492 ILE A N 1 ATOM 3807 C CA . ILE A 1 491 ? -24.784 -7.150 -0.762 1.00 67.20 ? 492 ILE A CA 1 ATOM 3808 C C . ILE A 1 491 ? -26.056 -7.621 -1.516 1.00 67.99 ? 492 ILE A C 1 ATOM 3809 O O . ILE A 1 491 ? -27.131 -7.777 -0.917 1.00 73.07 ? 492 ILE A O 1 ATOM 3810 C CB . ILE A 1 491 ? -24.716 -7.621 0.730 1.00 62.63 ? 492 ILE A CB 1 ATOM 3811 C CG1 . ILE A 1 491 ? -23.471 -7.058 1.444 1.00 64.48 ? 492 ILE A CG1 1 ATOM 3812 C CG2 . ILE A 1 491 ? -24.758 -9.135 0.859 1.00 56.71 ? 492 ILE A CG2 1 ATOM 3813 C CD1 . ILE A 1 491 ? -23.721 -5.820 2.303 1.00 74.16 ? 492 ILE A CD1 1 ATOM 3814 N N . TYR A 1 492 ? -25.947 -7.828 -2.829 1.00 65.34 ? 493 TYR A N 1 ATOM 3815 C CA . TYR A 1 492 ? -27.120 -8.236 -3.607 1.00 64.97 ? 493 TYR A CA 1 ATOM 3816 C C . TYR A 1 492 ? -27.406 -9.654 -3.250 1.00 70.29 ? 493 TYR A C 1 ATOM 3817 O O . TYR A 1 492 ? -26.483 -10.455 -3.108 1.00 75.17 ? 493 TYR A O 1 ATOM 3818 C CB . TYR A 1 492 ? -26.894 -8.122 -5.108 1.00 65.82 ? 493 TYR A CB 1 ATOM 3819 C CG . TYR A 1 492 ? -26.424 -6.751 -5.558 1.00 73.88 ? 493 TYR A CG 1 ATOM 3820 C CD1 . TYR A 1 492 ? -27.344 -5.726 -5.843 1.00 74.30 ? 493 TYR A CD1 1 ATOM 3821 C CD2 . TYR A 1 492 ? -25.056 -6.462 -5.687 1.00 69.93 ? 493 TYR A CD2 1 ATOM 3822 C CE1 . TYR A 1 492 ? -26.916 -4.459 -6.239 1.00 67.85 ? 493 TYR A CE1 1 ATOM 3823 C CE2 . TYR A 1 492 ? -24.629 -5.202 -6.096 1.00 64.98 ? 493 TYR A CE2 1 ATOM 3824 C CZ . TYR A 1 492 ? -25.557 -4.205 -6.362 1.00 62.66 ? 493 TYR A CZ 1 ATOM 3825 O OH . TYR A 1 492 ? -25.125 -2.961 -6.770 1.00 62.59 ? 493 TYR A OH 1 ATOM 3826 N N . THR A 1 493 ? -28.686 -9.950 -3.054 1.00 78.17 ? 494 THR A N 1 ATOM 3827 C CA . THR A 1 493 ? -29.133 -11.290 -2.639 1.00 74.72 ? 494 THR A CA 1 ATOM 3828 C C . THR A 1 493 ? -30.262 -11.829 -3.522 1.00 75.33 ? 494 THR A C 1 ATOM 3829 O O . THR A 1 493 ? -30.854 -12.871 -3.222 1.00 84.36 ? 494 THR A O 1 ATOM 3830 C CB . THR A 1 493 ? -29.629 -11.286 -1.189 1.00 73.08 ? 494 THR A CB 1 ATOM 3831 O OG1 . THR A 1 493 ? -30.726 -10.376 -1.081 1.00 83.35 ? 494 THR A OG1 1 ATOM 3832 C CG2 . THR A 1 493 ? -28.523 -10.880 -0.210 1.00 74.68 ? 494 THR A CG2 1 ATOM 3833 N N . ASP A 1 494 ? -30.553 -11.107 -4.601 1.00 76.70 ? 495 ASP A N 1 ATOM 3834 C CA . ASP A 1 494 ? -31.614 -11.448 -5.544 1.00 76.47 ? 495 ASP A CA 1 ATOM 3835 C C . ASP A 1 494 ? -31.084 -11.204 -6.967 1.00 81.19 ? 495 ASP A C 1 ATOM 3836 O O . ASP A 1 494 ? -31.521 -10.278 -7.674 1.00 77.90 ? 495 ASP A O 1 ATOM 3837 C CB . ASP A 1 494 ? -32.880 -10.633 -5.228 1.00 74.94 ? 495 ASP A CB 1 ATOM 3838 C CG . ASP A 1 494 ? -34.120 -11.142 -5.948 1.00 77.66 ? 495 ASP A CG 1 ATOM 3839 O OD1 . ASP A 1 494 ? -34.104 -12.280 -6.469 1.00 87.32 ? 495 ASP A OD1 1 ATOM 3840 O OD2 . ASP A 1 494 ? -35.131 -10.399 -5.981 1.00 72.56 ? 495 ASP A OD2 1 ATOM 3841 N N . CYS A 1 495 ? -30.120 -12.050 -7.351 1.00 82.59 ? 496 CYS A N 1 ATOM 3842 C CA . CYS A 1 495 ? -29.416 -11.973 -8.631 1.00 75.56 ? 496 CYS A CA 1 ATOM 3843 C C . CYS A 1 495 ? -29.849 -13.049 -9.629 1.00 80.62 ? 496 CYS A C 1 ATOM 3844 O O . CYS A 1 495 ? -30.183 -14.183 -9.246 1.00 75.85 ? 496 CYS A O 1 ATOM 3845 C CB . CYS A 1 495 ? -27.925 -11.987 -8.380 1.00 74.58 ? 496 CYS A CB 1 ATOM 3846 S SG . CYS A 1 495 ? -27.437 -10.514 -7.448 1.00 91.08 ? 496 CYS A SG 1 ATOM 3847 N N . TRP A 1 496 ? -29.891 -12.658 -10.904 1.00 82.72 ? 497 TRP A N 1 ATOM 3848 C CA . TRP A 1 496 ? -30.564 -13.427 -11.959 1.00 85.52 ? 497 TRP A CA 1 ATOM 3849 C C . TRP A 1 496 ? -29.816 -13.328 -13.299 1.00 92.52 ? 497 TRP A C 1 ATOM 3850 O O . TRP A 1 496 ? -29.575 -12.215 -13.820 1.00 98.29 ? 497 TRP A O 1 ATOM 3851 C CB . TRP A 1 496 ? -32.030 -12.960 -12.155 1.00 84.34 ? 497 TRP A CB 1 ATOM 3852 C CG . TRP A 1 496 ? -33.002 -13.158 -10.954 1.00 92.93 ? 497 TRP A CG 1 ATOM 3853 C CD1 . TRP A 1 496 ? -32.939 -12.543 -9.718 1.00 92.41 ? 497 TRP A CD1 1 ATOM 3854 C CD2 . TRP A 1 496 ? -34.189 -13.978 -10.916 1.00 87.76 ? 497 TRP A CD2 1 ATOM 3855 N NE1 . TRP A 1 496 ? -33.980 -12.954 -8.922 1.00 83.55 ? 497 TRP A NE1 1 ATOM 3856 C CE2 . TRP A 1 496 ? -34.764 -13.827 -9.625 1.00 84.55 ? 497 TRP A CE2 1 ATOM 3857 C CE3 . TRP A 1 496 ? -34.811 -14.837 -11.839 1.00 82.96 ? 497 TRP A CE3 1 ATOM 3858 C CZ2 . TRP A 1 496 ? -35.925 -14.496 -9.242 1.00 82.61 ? 497 TRP A CZ2 1 ATOM 3859 C CZ3 . TRP A 1 496 ? -35.964 -15.498 -11.459 1.00 78.15 ? 497 TRP A CZ3 1 ATOM 3860 C CH2 . TRP A 1 496 ? -36.513 -15.320 -10.171 1.00 82.92 ? 497 TRP A CH2 1 ATOM 3861 N N . VAL A 1 497 ? -29.459 -14.503 -13.837 1.00 84.91 ? 498 VAL A N 1 ATOM 3862 C CA . VAL A 1 497 ? -28.940 -14.653 -15.208 1.00 72.48 ? 498 VAL A CA 1 ATOM 3863 C C . VAL A 1 497 ? -30.040 -15.039 -16.209 1.00 76.72 ? 498 VAL A C 1 ATOM 3864 O O . VAL A 1 497 ? -30.859 -15.949 -15.975 1.00 69.02 ? 498 VAL A O 1 ATOM 3865 C CB . VAL A 1 497 ? -27.730 -15.608 -15.302 1.00 64.22 ? 498 VAL A CB 1 ATOM 3866 C CG1 . VAL A 1 497 ? -26.756 -15.302 -14.188 1.00 67.23 ? 498 VAL A CG1 1 ATOM 3867 C CG2 . VAL A 1 497 ? -28.143 -17.069 -15.245 1.00 57.73 ? 498 VAL A CG2 1 ATOM 3868 N N . THR A 1 498 ? -30.041 -14.323 -17.323 1.00 78.60 ? 499 THR A N 1 ATOM 3869 C CA . THR A 1 498 ? -30.988 -14.551 -18.386 1.00 75.84 ? 499 THR A CA 1 ATOM 3870 C C . THR A 1 498 ? -30.231 -14.823 -19.663 1.00 81.47 ? 499 THR A C 1 ATOM 3871 O O . THR A 1 498 ? -29.047 -14.422 -19.824 1.00 86.00 ? 499 THR A O 1 ATOM 3872 C CB . THR A 1 498 ? -31.937 -13.348 -18.574 1.00 83.66 ? 499 THR A CB 1 ATOM 3873 O OG1 . THR A 1 498 ? -31.246 -12.132 -18.265 1.00 100.54 ? 499 THR A OG1 1 ATOM 3874 C CG2 . THR A 1 498 ? -33.119 -13.454 -17.642 1.00 87.92 ? 499 THR A CG2 1 ATOM 3875 N N . GLY A 1 499 ? -30.915 -15.542 -20.548 1.00 82.89 ? 500 GLY A N 1 ATOM 3876 C CA . GLY A 1 499 ? -30.466 -15.737 -21.910 1.00 92.11 ? 500 GLY A CA 1 ATOM 3877 C C . GLY A 1 499 ? -31.077 -16.910 -22.643 1.00 100.82 ? 500 GLY A C 1 ATOM 3878 O O . GLY A 1 499 ? -32.127 -17.444 -22.273 1.00 103.49 ? 500 GLY A O 1 ATOM 3879 N N . TRP A 1 500 ? -30.405 -17.268 -23.729 1.00 108.15 ? 501 TRP A N 1 ATOM 3880 C CA . TRP A 1 500 ? -30.621 -18.512 -24.443 1.00 100.40 ? 501 TRP A CA 1 ATOM 3881 C C . TRP A 1 500 ? -29.362 -19.385 -24.127 1.00 102.42 ? 501 TRP A C 1 ATOM 3882 O O . TRP A 1 500 ? -28.698 -19.166 -23.100 1.00 98.12 ? 501 TRP A O 1 ATOM 3883 C CB . TRP A 1 500 ? -30.862 -18.182 -25.921 1.00 86.85 ? 501 TRP A CB 1 ATOM 3884 C CG . TRP A 1 500 ? -32.175 -17.406 -26.160 1.00 80.64 ? 501 TRP A CG 1 ATOM 3885 C CD1 . TRP A 1 500 ? -33.355 -17.941 -26.570 1.00 91.85 ? 501 TRP A CD1 1 ATOM 3886 C CD2 . TRP A 1 500 ? -32.425 -15.990 -25.996 1.00 78.86 ? 501 TRP A CD2 1 ATOM 3887 N NE1 . TRP A 1 500 ? -34.325 -16.970 -26.684 1.00 89.05 ? 501 TRP A NE1 1 ATOM 3888 C CE2 . TRP A 1 500 ? -33.788 -15.762 -26.336 1.00 82.61 ? 501 TRP A CE2 1 ATOM 3889 C CE3 . TRP A 1 500 ? -31.640 -14.894 -25.598 1.00 77.76 ? 501 TRP A CE3 1 ATOM 3890 C CZ2 . TRP A 1 500 ? -34.389 -14.478 -26.291 1.00 80.01 ? 501 TRP A CZ2 1 ATOM 3891 C CZ3 . TRP A 1 500 ? -32.244 -13.609 -25.550 1.00 78.90 ? 501 TRP A CZ3 1 ATOM 3892 C CH2 . TRP A 1 500 ? -33.606 -13.421 -25.897 1.00 75.71 ? 501 TRP A CH2 1 ATOM 3893 N N . GLY A 1 501 ? -29.028 -20.364 -24.958 1.00 104.85 ? 502 GLY A N 1 ATOM 3894 C CA . GLY A 1 501 ? -27.961 -21.316 -24.605 1.00 108.30 ? 502 GLY A CA 1 ATOM 3895 C C . GLY A 1 501 ? -26.499 -20.861 -24.623 1.00 112.54 ? 502 GLY A C 1 ATOM 3896 O O . GLY A 1 501 ? -25.698 -21.328 -23.804 1.00 109.82 ? 502 GLY A O 1 ATOM 3897 N N . TYR A 1 502 ? -26.161 -19.953 -25.546 1.00 113.95 ? 503 TYR A N 1 ATOM 3898 C CA . TYR A 1 502 ? -24.768 -19.641 -25.934 1.00 110.66 ? 503 TYR A CA 1 ATOM 3899 C C . TYR A 1 502 ? -23.855 -19.132 -24.791 1.00 104.85 ? 503 TYR A C 1 ATOM 3900 O O . TYR A 1 502 ? -22.919 -19.812 -24.335 1.00 86.93 ? 503 TYR A O 1 ATOM 3901 C CB . TYR A 1 502 ? -24.782 -18.651 -27.118 1.00 112.49 ? 503 TYR A CB 1 ATOM 3902 C CG . TYR A 1 502 ? -23.796 -18.976 -28.236 1.00 125.75 ? 503 TYR A CG 1 ATOM 3903 C CD1 . TYR A 1 502 ? -23.989 -20.095 -29.071 1.00 120.71 ? 503 TYR A CD1 1 ATOM 3904 C CD2 . TYR A 1 502 ? -22.674 -18.163 -28.470 1.00 125.27 ? 503 TYR A CD2 1 ATOM 3905 C CE1 . TYR A 1 502 ? -23.099 -20.393 -30.094 1.00 108.71 ? 503 TYR A CE1 1 ATOM 3906 C CE2 . TYR A 1 502 ? -21.781 -18.454 -29.495 1.00 119.10 ? 503 TYR A CE2 1 ATOM 3907 C CZ . TYR A 1 502 ? -22.002 -19.571 -30.298 1.00 116.40 ? 503 TYR A CZ 1 ATOM 3908 O OH . TYR A 1 502 ? -21.128 -19.872 -31.311 1.00 125.09 ? 503 TYR A OH 1 ATOM 3909 N N . ASP A 1 507 ? -21.365 -25.211 -29.889 1.00 106.45 ? 508 ASP A N 1 ATOM 3910 C CA . ASP A 1 507 ? -22.237 -24.778 -28.805 1.00 116.80 ? 508 ASP A CA 1 ATOM 3911 C C . ASP A 1 507 ? -23.721 -25.137 -29.085 1.00 116.31 ? 508 ASP A C 1 ATOM 3912 O O . ASP A 1 507 ? -24.028 -25.664 -30.161 1.00 120.07 ? 508 ASP A O 1 ATOM 3913 C CB . ASP A 1 507 ? -22.031 -23.276 -28.583 1.00 115.40 ? 508 ASP A CB 1 ATOM 3914 C CG . ASP A 1 507 ? -21.871 -22.915 -27.117 1.00 123.92 ? 508 ASP A CG 1 ATOM 3915 O OD1 . ASP A 1 507 ? -22.412 -23.645 -26.248 1.00 126.06 ? 508 ASP A OD1 1 ATOM 3916 O OD2 . ASP A 1 507 ? -21.204 -21.893 -26.833 1.00 119.06 ? 508 ASP A OD2 1 ATOM 3917 N N . LYS A 1 508 ? -24.628 -24.871 -28.135 1.00 106.11 ? 509 LYS A N 1 ATOM 3918 C CA . LYS A 1 508 ? -26.058 -25.227 -28.294 1.00 110.74 ? 509 LYS A CA 1 ATOM 3919 C C . LYS A 1 508 ? -27.043 -24.138 -27.854 1.00 109.57 ? 509 LYS A C 1 ATOM 3920 O O . LYS A 1 508 ? -26.925 -23.653 -26.729 1.00 115.29 ? 509 LYS A O 1 ATOM 3921 C CB . LYS A 1 508 ? -26.362 -26.530 -27.534 1.00 115.02 ? 509 LYS A CB 1 ATOM 3922 C CG . LYS A 1 508 ? -26.191 -27.794 -28.354 1.00 116.53 ? 509 LYS A CG 1 ATOM 3923 C CD . LYS A 1 508 ? -27.310 -27.931 -29.385 1.00 120.46 ? 509 LYS A CD 1 ATOM 3924 C CE . LYS A 1 508 ? -26.769 -28.382 -30.737 1.00 129.26 ? 509 LYS A CE 1 ATOM 3925 N NZ . LYS A 1 508 ? -26.042 -29.687 -30.642 1.00 138.47 ? 509 LYS A NZ 1 ATOM 3926 N N . ILE A 1 509 ? -28.018 -23.772 -28.705 1.00 105.65 ? 510 ILE A N 1 ATOM 3927 C CA . ILE A 1 509 ? -28.984 -22.660 -28.376 1.00 105.23 ? 510 ILE A CA 1 ATOM 3928 C C . ILE A 1 509 ? -30.472 -23.037 -28.167 1.00 109.37 ? 510 ILE A C 1 ATOM 3929 O O . ILE A 1 509 ? -31.083 -23.709 -29.007 1.00 118.98 ? 510 ILE A O 1 ATOM 3930 C CB . ILE A 1 509 ? -28.866 -21.397 -29.308 1.00 95.93 ? 510 ILE A CB 1 ATOM 3931 C CG1 . ILE A 1 509 ? -29.373 -21.645 -30.730 1.00 91.14 ? 510 ILE A CG1 1 ATOM 3932 C CG2 . ILE A 1 509 ? -27.441 -20.852 -29.366 1.00 100.68 ? 510 ILE A CG2 1 ATOM 3933 C CD1 . ILE A 1 509 ? -30.658 -20.917 -31.039 1.00 82.36 ? 510 ILE A CD1 1 ATOM 3934 N N . GLN A 1 510 ? -31.033 -22.579 -27.044 1.00 105.66 ? 511 GLN A N 1 ATOM 3935 C CA . GLN A 1 510 ? -32.441 -22.801 -26.675 1.00 104.52 ? 511 GLN A CA 1 ATOM 3936 C C . GLN A 1 510 ? -33.368 -21.818 -27.418 1.00 105.90 ? 511 GLN A C 1 ATOM 3937 O O . GLN A 1 510 ? -32.961 -20.694 -27.700 1.00 101.68 ? 511 GLN A O 1 ATOM 3938 C CB . GLN A 1 510 ? -32.587 -22.646 -25.159 1.00 103.42 ? 511 GLN A CB 1 ATOM 3939 C CG . GLN A 1 510 ? -34.001 -22.795 -24.610 1.00 119.87 ? 511 GLN A CG 1 ATOM 3940 C CD . GLN A 1 510 ? -34.354 -24.207 -24.168 1.00 128.62 ? 511 GLN A CD 1 ATOM 3941 O OE1 . GLN A 1 510 ? -33.511 -24.956 -23.669 1.00 131.01 ? 511 GLN A OE1 1 ATOM 3942 N NE2 . GLN A 1 510 ? -35.626 -24.565 -24.322 1.00 136.41 ? 511 GLN A NE2 1 ATOM 3943 N N . ASN A 1 511 ? -34.599 -22.244 -27.730 1.00 106.84 ? 512 ASN A N 1 ATOM 3944 C CA . ASN A 1 511 ? -35.569 -21.411 -28.471 1.00 109.95 ? 512 ASN A CA 1 ATOM 3945 C C . ASN A 1 511 ? -36.200 -20.314 -27.612 1.00 116.23 ? 512 ASN A C 1 ATOM 3946 O O . ASN A 1 511 ? -36.159 -19.126 -27.971 1.00 111.05 ? 512 ASN A O 1 ATOM 3947 C CB . ASN A 1 511 ? -36.650 -22.283 -29.144 1.00 108.57 ? 512 ASN A CB 1 ATOM 3948 C CG . ASN A 1 511 ? -37.842 -21.473 -29.669 1.00 110.54 ? 512 ASN A CG 1 ATOM 3949 O OD1 . ASN A 1 511 ? -37.685 -20.404 -30.276 1.00 103.24 ? 512 ASN A OD1 1 ATOM 3950 N ND2 . ASN A 1 511 ? -39.046 -21.999 -29.448 1.00 109.86 ? 512 ASN A ND2 1 ATOM 3951 N N . THR A 1 512 ? -36.800 -20.726 -26.498 1.00 112.57 ? 513 THR A N 1 ATOM 3952 C CA . THR A 1 512 ? -37.394 -19.794 -25.554 1.00 110.78 ? 513 THR A CA 1 ATOM 3953 C C . THR A 1 512 ? -36.307 -19.213 -24.651 1.00 111.06 ? 513 THR A C 1 ATOM 3954 O O . THR A 1 512 ? -35.353 -19.912 -24.279 1.00 99.18 ? 513 THR A O 1 ATOM 3955 C CB . THR A 1 512 ? -38.520 -20.465 -24.732 1.00 111.37 ? 513 THR A CB 1 ATOM 3956 O OG1 . THR A 1 512 ? -39.366 -21.199 -25.620 1.00 115.50 ? 513 THR A OG1 1 ATOM 3957 C CG2 . THR A 1 512 ? -39.386 -19.428 -23.989 1.00 102.48 ? 513 THR A CG2 1 ATOM 3958 N N . LEU A 1 513 ? -36.467 -17.925 -24.331 1.00 112.29 ? 514 LEU A N 1 ATOM 3959 C CA . LEU A 1 513 ? -35.651 -17.211 -23.338 1.00 101.44 ? 514 LEU A CA 1 ATOM 3960 C C . LEU A 1 513 ? -35.675 -17.889 -21.957 1.00 94.86 ? 514 LEU A C 1 ATOM 3961 O O . LEU A 1 513 ? -36.715 -17.917 -21.275 1.00 85.69 ? 514 LEU A O 1 ATOM 3962 C CB . LEU A 1 513 ? -36.087 -15.731 -23.261 1.00 95.90 ? 514 LEU A CB 1 ATOM 3963 C CG . LEU A 1 513 ? -35.562 -14.693 -22.248 1.00 90.29 ? 514 LEU A CG 1 ATOM 3964 C CD1 . LEU A 1 513 ? -34.044 -14.597 -22.167 1.00 78.51 ? 514 LEU A CD1 1 ATOM 3965 C CD2 . LEU A 1 513 ? -36.157 -13.331 -22.585 1.00 92.29 ? 514 LEU A CD2 1 ATOM 3966 N N . GLN A 1 514 ? -34.520 -18.455 -21.592 1.00 95.32 ? 515 GLN A N 1 ATOM 3967 C CA . GLN A 1 514 ? -34.283 -19.104 -20.295 1.00 100.61 ? 515 GLN A CA 1 ATOM 3968 C C . GLN A 1 514 ? -34.049 -18.094 -19.168 1.00 95.91 ? 515 GLN A C 1 ATOM 3969 O O . GLN A 1 514 ? -33.269 -17.155 -19.318 1.00 88.76 ? 515 GLN A O 1 ATOM 3970 C CB . GLN A 1 514 ? -33.082 -20.074 -20.379 1.00 107.18 ? 515 GLN A CB 1 ATOM 3971 C CG . GLN A 1 514 ? -33.343 -21.381 -21.127 1.00 109.83 ? 515 GLN A CG 1 ATOM 3972 C CD . GLN A 1 514 ? -34.508 -22.192 -20.556 1.00 107.62 ? 515 GLN A CD 1 ATOM 3973 O OE1 . GLN A 1 514 ? -35.637 -22.098 -21.045 1.00 106.40 ? 515 GLN A OE1 1 ATOM 3974 N NE2 . GLN A 1 514 ? -34.240 -22.981 -19.513 1.00 97.63 ? 515 GLN A NE2 1 ATOM 3975 N N . LYS A 1 515 ? -34.736 -18.293 -18.046 1.00 101.18 ? 516 LYS A N 1 ATOM 3976 C CA . LYS A 1 515 ? -34.540 -17.461 -16.852 1.00 97.87 ? 516 LYS A CA 1 ATOM 3977 C C . LYS A 1 515 ? -34.217 -18.322 -15.630 1.00 91.50 ? 516 LYS A C 1 ATOM 3978 O O . LYS A 1 515 ? -34.824 -19.372 -15.427 1.00 97.32 ? 516 LYS A O 1 ATOM 3979 C CB . LYS A 1 515 ? -35.745 -16.545 -16.599 1.00 98.57 ? 516 LYS A CB 1 ATOM 3980 C CG . LYS A 1 515 ? -37.040 -17.258 -16.251 1.00 104.64 ? 516 LYS A CG 1 ATOM 3981 C CD . LYS A 1 515 ? -37.780 -16.504 -15.165 1.00 104.00 ? 516 LYS A CD 1 ATOM 3982 C CE . LYS A 1 515 ? -39.007 -17.273 -14.724 1.00 108.60 ? 516 LYS A CE 1 ATOM 3983 N NZ . LYS A 1 515 ? -40.167 -16.370 -14.496 1.00 104.50 ? 516 LYS A NZ 1 ATOM 3984 N N . ALA A 1 516 ? -33.247 -17.875 -14.838 1.00 85.22 ? 517 ALA A N 1 ATOM 3985 C CA . ALA A 1 516 ? -32.698 -18.657 -13.728 1.00 82.23 ? 517 ALA A CA 1 ATOM 3986 C C . ALA A 1 516 ? -32.033 -17.733 -12.697 1.00 78.88 ? 517 ALA A C 1 ATOM 3987 O O . ALA A 1 516 ? -31.113 -16.992 -13.042 1.00 81.61 ? 517 ALA A O 1 ATOM 3988 C CB . ALA A 1 516 ? -31.703 -19.699 -14.257 1.00 77.86 ? 517 ALA A CB 1 ATOM 3989 N N . LYS A 1 517 ? -32.517 -17.772 -11.450 1.00 75.27 ? 518 LYS A N 1 ATOM 3990 C CA . LYS A 1 517 ? -31.960 -16.997 -10.317 1.00 78.60 ? 518 LYS A CA 1 ATOM 3991 C C . LYS A 1 517 ? -30.712 -17.657 -9.726 1.00 77.45 ? 518 LYS A C 1 ATOM 3992 O O . LYS A 1 517 ? -30.731 -18.825 -9.380 1.00 79.61 ? 518 LYS A O 1 ATOM 3993 C CB . LYS A 1 517 ? -33.010 -16.831 -9.210 1.00 78.90 ? 518 LYS A CB 1 ATOM 3994 C CG . LYS A 1 517 ? -32.479 -16.222 -7.927 1.00 75.15 ? 518 LYS A CG 1 ATOM 3995 C CD . LYS A 1 517 ? -33.463 -16.337 -6.782 1.00 77.15 ? 518 LYS A CD 1 ATOM 3996 C CE . LYS A 1 517 ? -32.798 -15.848 -5.502 1.00 87.71 ? 518 LYS A CE 1 ATOM 3997 N NZ . LYS A 1 517 ? -33.788 -15.412 -4.489 1.00 90.02 ? 518 LYS A NZ 1 ATOM 3998 N N . ILE A 1 518 ? -29.646 -16.885 -9.576 1.00 79.93 ? 519 ILE A N 1 ATOM 3999 C CA . ILE A 1 518 ? -28.346 -17.429 -9.222 1.00 80.19 ? 519 ILE A CA 1 ATOM 4000 C C . ILE A 1 518 ? -27.752 -16.636 -8.053 1.00 75.98 ? 519 ILE A C 1 ATOM 4001 O O . ILE A 1 518 ? -27.994 -15.426 -7.948 1.00 71.01 ? 519 ILE A O 1 ATOM 4002 C CB . ILE A 1 518 ? -27.434 -17.533 -10.496 1.00 92.83 ? 519 ILE A CB 1 ATOM 4003 C CG1 . ILE A 1 518 ? -27.565 -18.929 -11.133 1.00 103.69 ? 519 ILE A CG1 1 ATOM 4004 C CG2 . ILE A 1 518 ? -25.947 -17.302 -10.219 1.00 87.05 ? 519 ILE A CG2 1 ATOM 4005 C CD1 . ILE A 1 518 ? -28.672 -19.105 -12.160 1.00 103.39 ? 519 ILE A CD1 1 ATOM 4006 N N . PRO A 1 519 ? -27.008 -17.324 -7.150 1.00 74.79 ? 520 PRO A N 1 ATOM 4007 C CA . PRO A 1 519 ? -26.320 -16.595 -6.083 1.00 72.45 ? 520 PRO A CA 1 ATOM 4008 C C . PRO A 1 519 ? -24.939 -16.106 -6.493 1.00 68.87 ? 520 PRO A C 1 ATOM 4009 O O . PRO A 1 519 ? -24.195 -16.833 -7.151 1.00 72.34 ? 520 PRO A O 1 ATOM 4010 C CB . PRO A 1 519 ? -26.216 -17.625 -4.940 1.00 72.54 ? 520 PRO A CB 1 ATOM 4011 C CG . PRO A 1 519 ? -26.528 -18.962 -5.534 1.00 74.17 ? 520 PRO A CG 1 ATOM 4012 C CD . PRO A 1 519 ? -26.878 -18.788 -6.985 1.00 75.87 ? 520 PRO A CD 1 ATOM 4013 N N . LEU A 1 520 ? -24.628 -14.869 -6.103 1.00 68.88 ? 521 LEU A N 1 ATOM 4014 C CA . LEU A 1 520 ? -23.276 -14.304 -6.159 1.00 68.72 ? 521 LEU A CA 1 ATOM 4015 C C . LEU A 1 520 ? -22.321 -15.139 -5.299 1.00 65.25 ? 521 LEU A C 1 ATOM 4016 O O . LEU A 1 520 ? -22.763 -15.885 -4.442 1.00 71.02 ? 521 LEU A O 1 ATOM 4017 C CB . LEU A 1 520 ? -23.292 -12.833 -5.691 1.00 68.75 ? 521 LEU A CB 1 ATOM 4018 C CG . LEU A 1 520 ? -23.929 -11.736 -6.562 1.00 64.80 ? 521 LEU A CG 1 ATOM 4019 C CD1 . LEU A 1 520 ? -23.912 -10.369 -5.895 1.00 66.60 ? 521 LEU A CD1 1 ATOM 4020 C CD2 . LEU A 1 520 ? -23.184 -11.625 -7.871 1.00 73.36 ? 521 LEU A CD2 1 ATOM 4021 N N . VAL A 1 521 ? -21.022 -15.035 -5.544 1.00 62.23 ? 522 VAL A N 1 ATOM 4022 C CA . VAL A 1 521 ? -20.019 -15.872 -4.876 1.00 63.71 ? 522 VAL A CA 1 ATOM 4023 C C . VAL A 1 521 ? -18.832 -14.947 -4.717 1.00 62.52 ? 522 VAL A C 1 ATOM 4024 O O . VAL A 1 521 ? -18.452 -14.278 -5.666 1.00 68.98 ? 522 VAL A O 1 ATOM 4025 C CB . VAL A 1 521 ? -19.638 -17.099 -5.766 1.00 71.26 ? 522 VAL A CB 1 ATOM 4026 C CG1 . VAL A 1 521 ? -18.364 -17.788 -5.293 1.00 65.33 ? 522 VAL A CG1 1 ATOM 4027 C CG2 . VAL A 1 521 ? -20.791 -18.103 -5.896 1.00 73.88 ? 522 VAL A CG2 1 ATOM 4028 N N . THR A 1 522 ? -18.230 -14.901 -3.542 1.00 63.92 ? 523 THR A N 1 ATOM 4029 C CA . THR A 1 522 ? -17.178 -13.916 -3.315 1.00 70.55 ? 523 THR A CA 1 ATOM 4030 C C . THR A 1 522 ? -15.899 -14.158 -4.128 1.00 79.04 ? 523 THR A C 1 ATOM 4031 O O . THR A 1 522 ? -15.576 -15.290 -4.487 1.00 74.73 ? 523 THR A O 1 ATOM 4032 C CB . THR A 1 522 ? -16.875 -13.743 -1.831 1.00 70.18 ? 523 THR A CB 1 ATOM 4033 O OG1 . THR A 1 522 ? -16.950 -15.021 -1.197 1.00 73.24 ? 523 THR A OG1 1 ATOM 4034 C CG2 . THR A 1 522 ? -17.885 -12.772 -1.202 1.00 67.32 ? 523 THR A CG2 1 ATOM 4035 N N . ASN A 1 523 ? -15.211 -13.059 -4.440 1.00 91.17 ? 524 ASN A N 1 ATOM 4036 C CA . ASN A 1 523 ? -13.991 -13.075 -5.237 1.00 102.81 ? 524 ASN A CA 1 ATOM 4037 C C . ASN A 1 523 ? -12.920 -13.980 -4.650 1.00 107.81 ? 524 ASN A C 1 ATOM 4038 O O . ASN A 1 523 ? -12.450 -14.897 -5.326 1.00 114.50 ? 524 ASN A O 1 ATOM 4039 C CB . ASN A 1 523 ? -13.487 -11.650 -5.477 1.00 102.40 ? 524 ASN A CB 1 ATOM 4040 C CG . ASN A 1 523 ? -13.985 -11.073 -6.796 1.00 101.46 ? 524 ASN A CG 1 ATOM 4041 O OD1 . ASN A 1 523 ? -15.094 -11.370 -7.264 1.00 92.81 ? 524 ASN A OD1 1 ATOM 4042 N ND2 . ASN A 1 523 ? -13.150 -10.255 -7.416 1.00 109.18 ? 524 ASN A ND2 1 ATOM 4043 N N . GLU A 1 524 ? -12.579 -13.728 -3.388 1.00 112.28 ? 525 GLU A N 1 ATOM 4044 C CA . GLU A 1 524 ? -11.849 -14.675 -2.535 1.00 115.36 ? 525 GLU A CA 1 ATOM 4045 C C . GLU A 1 524 ? -12.301 -16.132 -2.747 1.00 93.65 ? 525 GLU A C 1 ATOM 4046 O O . GLU A 1 524 ? -11.499 -16.986 -3.074 1.00 85.90 ? 525 GLU A O 1 ATOM 4047 C CB . GLU A 1 524 ? -12.040 -14.278 -1.065 1.00 127.46 ? 525 GLU A CB 1 ATOM 4048 C CG . GLU A 1 524 ? -11.009 -14.829 -0.099 1.00 129.57 ? 525 GLU A CG 1 ATOM 4049 C CD . GLU A 1 524 ? -11.071 -14.133 1.243 1.00 133.83 ? 525 GLU A CD 1 ATOM 4050 O OE1 . GLU A 1 524 ? -12.008 -14.400 2.021 1.00 119.90 ? 525 GLU A OE1 1 ATOM 4051 O OE2 . GLU A 1 524 ? -10.178 -13.306 1.514 1.00 150.73 ? 525 GLU A OE2 1 ATOM 4052 N N . GLU A 1 525 ? -13.594 -16.381 -2.590 1.00 86.99 ? 526 GLU A N 1 ATOM 4053 C CA . GLU A 1 525 ? -14.160 -17.718 -2.667 1.00 91.27 ? 526 GLU A CA 1 ATOM 4054 C C . GLU A 1 525 ? -14.011 -18.326 -4.050 1.00 95.83 ? 526 GLU A C 1 ATOM 4055 O O . GLU A 1 525 ? -13.776 -19.527 -4.177 1.00 99.66 ? 526 GLU A O 1 ATOM 4056 C CB . GLU A 1 525 ? -15.635 -17.657 -2.265 1.00 96.80 ? 526 GLU A CB 1 ATOM 4057 C CG . GLU A 1 525 ? -16.513 -18.814 -2.710 1.00 96.52 ? 526 GLU A CG 1 ATOM 4058 C CD . GLU A 1 525 ? -16.325 -20.072 -1.896 1.00 107.36 ? 526 GLU A CD 1 ATOM 4059 O OE1 . GLU A 1 525 ? -15.658 -20.020 -0.834 1.00 121.53 ? 526 GLU A OE1 1 ATOM 4060 O OE2 . GLU A 1 525 ? -16.860 -21.120 -2.325 1.00 105.05 ? 526 GLU A OE2 1 ATOM 4061 N N . CYS A 1 526 ? -14.148 -17.492 -5.076 1.00 99.41 ? 527 CYS A N 1 ATOM 4062 C CA . CYS A 1 526 ? -14.077 -17.932 -6.468 1.00 101.81 ? 527 CYS A CA 1 ATOM 4063 C C . CYS A 1 526 ? -12.635 -18.275 -6.858 1.00 99.56 ? 527 CYS A C 1 ATOM 4064 O O . CYS A 1 526 ? -12.353 -19.370 -7.383 1.00 86.34 ? 527 CYS A O 1 ATOM 4065 C CB . CYS A 1 526 ? -14.611 -16.825 -7.356 1.00 106.85 ? 527 CYS A CB 1 ATOM 4066 S SG . CYS A 1 526 ? -15.452 -17.360 -8.857 1.00 109.02 ? 527 CYS A SG 1 ATOM 4067 N N . GLN A 1 527 ? -11.741 -17.326 -6.570 1.00 93.44 ? 528 GLN A N 1 ATOM 4068 C CA . GLN A 1 527 ? -10.298 -17.459 -6.713 1.00 87.12 ? 528 GLN A CA 1 ATOM 4069 C C . GLN A 1 527 ? -9.743 -18.828 -6.319 1.00 91.22 ? 528 GLN A C 1 ATOM 4070 O O . GLN A 1 527 ? -8.841 -19.340 -6.974 1.00 97.35 ? 528 GLN A O 1 ATOM 4071 C CB . GLN A 1 527 ? -9.620 -16.362 -5.893 1.00 83.15 ? 528 GLN A CB 1 ATOM 4072 C CG . GLN A 1 527 ? -8.114 -16.320 -5.999 1.00 77.98 ? 528 GLN A CG 1 ATOM 4073 C CD . GLN A 1 527 ? -7.666 -16.142 -7.415 1.00 73.60 ? 528 GLN A CD 1 ATOM 4074 O OE1 . GLN A 1 527 ? -7.366 -15.020 -7.843 1.00 77.47 ? 528 GLN A OE1 1 ATOM 4075 N NE2 . GLN A 1 527 ? -7.634 -17.239 -8.165 1.00 63.23 ? 528 GLN A NE2 1 ATOM 4076 N N . LYS A 1 528 ? -10.288 -19.398 -5.246 1.00 99.03 ? 529 LYS A N 1 ATOM 4077 C CA . LYS A 1 528 ? -9.933 -20.738 -4.771 1.00 110.38 ? 529 LYS A CA 1 ATOM 4078 C C . LYS A 1 528 ? -10.306 -21.806 -5.793 1.00 104.69 ? 529 LYS A C 1 ATOM 4079 O O . LYS A 1 528 ? -9.454 -22.607 -6.197 1.00 104.67 ? 529 LYS A O 1 ATOM 4080 C CB . LYS A 1 528 ? -10.581 -21.030 -3.402 1.00 114.40 ? 529 LYS A CB 1 ATOM 4081 C CG . LYS A 1 528 ? -9.727 -20.606 -2.198 1.00 114.57 ? 529 LYS A CG 1 ATOM 4082 C CD . LYS A 1 528 ? -10.543 -20.318 -0.936 1.00 117.98 ? 529 LYS A CD 1 ATOM 4083 C CE . LYS A 1 528 ? -11.182 -21.572 -0.347 1.00 121.33 ? 529 LYS A CE 1 ATOM 4084 N NZ . LYS A 1 528 ? -12.038 -21.281 0.837 1.00 123.32 ? 529 LYS A NZ 1 ATOM 4085 N N . ARG A 1 529 ? -11.561 -21.789 -6.233 1.00 100.96 ? 530 ARG A N 1 ATOM 4086 C CA . ARG A 1 529 ? -12.040 -22.741 -7.232 1.00 109.92 ? 530 ARG A CA 1 ATOM 4087 C C . ARG A 1 529 ? -11.299 -22.599 -8.587 1.00 113.26 ? 530 ARG A C 1 ATOM 4088 O O . ARG A 1 529 ? -11.276 -23.549 -9.368 1.00 123.80 ? 530 ARG A O 1 ATOM 4089 C CB . ARG A 1 529 ? -13.569 -22.633 -7.396 1.00 112.60 ? 530 ARG A CB 1 ATOM 4090 C CG . ARG A 1 529 ? -14.288 -23.937 -7.753 1.00 114.77 ? 530 ARG A CG 1 ATOM 4091 C CD . ARG A 1 529 ? -15.240 -24.434 -6.665 1.00 111.95 ? 530 ARG A CD 1 ATOM 4092 N NE . ARG A 1 529 ? -14.537 -25.161 -5.599 1.00 123.24 ? 530 ARG A NE 1 ATOM 4093 C CZ . ARG A 1 529 ? -15.083 -25.627 -4.467 1.00 118.22 ? 530 ARG A CZ 1 ATOM 4094 N NH1 . ARG A 1 529 ? -16.376 -25.466 -4.207 1.00 118.66 ? 530 ARG A NH1 1 ATOM 4095 N NH2 . ARG A 1 529 ? -14.322 -26.265 -3.579 1.00 105.04 ? 530 ARG A NH2 1 ATOM 4096 N N . TYR A 1 530 ? -10.671 -21.440 -8.838 1.00 109.05 ? 531 TYR A N 1 ATOM 4097 C CA . TYR A 1 530 ? -10.008 -21.150 -10.133 1.00 106.15 ? 531 TYR A CA 1 ATOM 4098 C C . TYR A 1 530 ? -8.482 -21.100 -10.054 1.00 104.23 ? 531 TYR A C 1 ATOM 4099 O O . TYR A 1 530 ? -7.875 -20.043 -9.799 1.00 90.17 ? 531 TYR A O 1 ATOM 4100 C CB . TYR A 1 530 ? -10.620 -19.915 -10.842 1.00 111.01 ? 531 TYR A CB 1 ATOM 4101 C CG . TYR A 1 530 ? -11.956 -20.222 -11.519 1.00 122.77 ? 531 TYR A CG 1 ATOM 4102 C CD1 . TYR A 1 530 ? -13.107 -20.528 -10.757 1.00 135.87 ? 531 TYR A CD1 1 ATOM 4103 C CD2 . TYR A 1 530 ? -12.076 -20.234 -12.914 1.00 119.77 ? 531 TYR A CD2 1 ATOM 4104 C CE1 . TYR A 1 530 ? -14.326 -20.835 -11.364 1.00 129.78 ? 531 TYR A CE1 1 ATOM 4105 C CE2 . TYR A 1 530 ? -13.296 -20.534 -13.528 1.00 122.27 ? 531 TYR A CE2 1 ATOM 4106 C CZ . TYR A 1 530 ? -14.413 -20.835 -12.747 1.00 123.04 ? 531 TYR A CZ 1 ATOM 4107 O OH . TYR A 1 530 ? -15.619 -21.137 -13.335 1.00 120.59 ? 531 TYR A OH 1 ATOM 4108 N N . ARG A 1 531 ? -7.892 -22.264 -10.330 1.00 111.39 ? 532 ARG A N 1 ATOM 4109 C CA . ARG A 1 531 ? -6.461 -22.542 -10.162 1.00 112.89 ? 532 ARG A CA 1 ATOM 4110 C C . ARG A 1 531 ? -5.530 -21.622 -10.970 1.00 119.05 ? 532 ARG A C 1 ATOM 4111 O O . ARG A 1 531 ? -4.880 -20.728 -10.397 1.00 113.04 ? 532 ARG A O 1 ATOM 4112 C CB . ARG A 1 531 ? -6.170 -24.031 -10.457 1.00 113.13 ? 532 ARG A CB 1 ATOM 4113 C CG . ARG A 1 531 ? -7.131 -25.050 -9.821 1.00 124.68 ? 532 ARG A CG 1 ATOM 4114 C CD . ARG A 1 531 ? -7.355 -24.881 -8.310 1.00 136.86 ? 532 ARG A CD 1 ATOM 4115 N NE . ARG A 1 531 ? -6.107 -24.877 -7.531 1.00 151.24 ? 532 ARG A NE 1 ATOM 4116 C CZ . ARG A 1 531 ? -5.883 -24.147 -6.434 1.00 152.54 ? 532 ARG A CZ 1 ATOM 4117 N NH1 . ARG A 1 531 ? -6.814 -23.327 -5.953 1.00 153.92 ? 532 ARG A NH1 1 ATOM 4118 N NH2 . ARG A 1 531 ? -4.709 -24.227 -5.814 1.00 144.05 ? 532 ARG A NH2 1 ATOM 4119 N N . GLY A 1 532 ? -5.509 -21.824 -12.293 1.00 124.68 ? 533 GLY A N 1 ATOM 4120 C CA . GLY A 1 532 ? -4.541 -21.185 -13.201 1.00 128.45 ? 533 GLY A CA 1 ATOM 4121 C C . GLY A 1 532 ? -4.689 -19.699 -13.484 1.00 126.82 ? 533 GLY A C 1 ATOM 4122 O O . GLY A 1 532 ? -3.704 -19.007 -13.782 1.00 115.43 ? 533 GLY A O 1 ATOM 4123 N N . HIS A 1 533 ? -5.918 -19.204 -13.386 1.00 134.75 ? 534 HIS A N 1 ATOM 4124 C CA . HIS A 1 533 ? -6.218 -17.827 -13.757 1.00 133.42 ? 534 HIS A CA 1 ATOM 4125 C C . HIS A 1 533 ? -6.478 -16.917 -12.560 1.00 120.68 ? 534 HIS A C 1 ATOM 4126 O O . HIS A 1 533 ? -7.122 -17.325 -11.582 1.00 119.61 ? 534 HIS A O 1 ATOM 4127 C CB . HIS A 1 533 ? -7.411 -17.789 -14.710 1.00 147.95 ? 534 HIS A CB 1 ATOM 4128 C CG . HIS A 1 533 ? -7.157 -18.447 -16.034 1.00 154.62 ? 534 HIS A CG 1 ATOM 4129 N ND1 . HIS A 1 533 ? -7.386 -19.789 -16.254 1.00 145.06 ? 534 HIS A ND1 1 ATOM 4130 C CD2 . HIS A 1 533 ? -6.712 -17.942 -17.211 1.00 150.90 ? 534 HIS A CD2 1 ATOM 4131 C CE1 . HIS A 1 533 ? -7.091 -20.082 -17.509 1.00 154.59 ? 534 HIS A CE1 1 ATOM 4132 N NE2 . HIS A 1 533 ? -6.682 -18.978 -18.112 1.00 150.31 ? 534 HIS A NE2 1 ATOM 4133 N N . LYS A 1 534 ? -5.959 -15.690 -12.673 1.00 107.00 ? 535 LYS A N 1 ATOM 4134 C CA . LYS A 1 534 ? -6.187 -14.580 -11.736 1.00 97.92 ? 535 LYS A CA 1 ATOM 4135 C C . LYS A 1 534 ? -7.614 -14.045 -11.835 1.00 102.37 ? 535 LYS A C 1 ATOM 4136 O O . LYS A 1 534 ? -8.097 -13.764 -12.931 1.00 110.03 ? 535 LYS A O 1 ATOM 4137 C CB . LYS A 1 534 ? -5.207 -13.449 -12.060 1.00 94.42 ? 535 LYS A CB 1 ATOM 4138 C CG . LYS A 1 534 ? -5.454 -12.104 -11.388 1.00 95.99 ? 535 LYS A CG 1 ATOM 4139 C CD . LYS A 1 534 ? -4.805 -11.021 -12.235 1.00 111.77 ? 535 LYS A CD 1 ATOM 4140 C CE . LYS A 1 534 ? -3.912 -10.103 -11.411 1.00 116.58 ? 535 LYS A CE 1 ATOM 4141 N NZ . LYS A 1 534 ? -2.694 -9.709 -12.177 1.00 107.55 ? 535 LYS A NZ 1 ATOM 4142 N N . ILE A 1 535 ? -8.275 -13.895 -10.691 1.00 99.35 ? 536 ILE A N 1 ATOM 4143 C CA . ILE A 1 535 ? -9.583 -13.234 -10.622 1.00 88.44 ? 536 ILE A CA 1 ATOM 4144 C C . ILE A 1 535 ? -9.422 -11.840 -9.981 1.00 91.21 ? 536 ILE A C 1 ATOM 4145 O O . ILE A 1 535 ? -9.303 -11.741 -8.757 1.00 92.72 ? 536 ILE A O 1 ATOM 4146 C CB . ILE A 1 535 ? -10.611 -14.125 -9.887 1.00 79.60 ? 536 ILE A CB 1 ATOM 4147 C CG1 . ILE A 1 535 ? -10.779 -15.437 -10.649 1.00 80.01 ? 536 ILE A CG1 1 ATOM 4148 C CG2 . ILE A 1 535 ? -11.956 -13.423 -9.707 1.00 76.77 ? 536 ILE A CG2 1 ATOM 4149 C CD1 . ILE A 1 535 ? -11.761 -16.395 -10.012 1.00 92.50 ? 536 ILE A CD1 1 ATOM 4150 N N . THR A 1 536 ? -9.383 -10.784 -10.808 1.00 92.07 ? 537 THR A N 1 ATOM 4151 C CA . THR A 1 536 ? -9.279 -9.393 -10.309 1.00 105.44 ? 537 THR A CA 1 ATOM 4152 C C . THR A 1 536 ? -10.575 -8.813 -9.727 1.00 105.83 ? 537 THR A C 1 ATOM 4153 O O . THR A 1 536 ? -11.673 -9.324 -9.980 1.00 97.11 ? 537 THR A O 1 ATOM 4154 C CB . THR A 1 536 ? -8.766 -8.390 -11.369 1.00 111.59 ? 537 THR A CB 1 ATOM 4155 O OG1 . THR A 1 536 ? -9.185 -8.797 -12.680 1.00 112.83 ? 537 THR A OG1 1 ATOM 4156 C CG2 . THR A 1 536 ? -7.252 -8.250 -11.295 1.00 115.55 ? 537 THR A CG2 1 ATOM 4157 N N . HIS A 1 537 ? -10.412 -7.733 -8.956 1.00 99.62 ? 538 HIS A N 1 ATOM 4158 C CA . HIS A 1 537 ? -11.501 -6.895 -8.459 1.00 91.83 ? 538 HIS A CA 1 ATOM 4159 C C . HIS A 1 537 ? -12.409 -6.352 -9.582 1.00 94.73 ? 538 HIS A C 1 ATOM 4160 O O . HIS A 1 537 ? -13.575 -6.019 -9.327 1.00 90.46 ? 538 HIS A O 1 ATOM 4161 C CB . HIS A 1 537 ? -10.922 -5.744 -7.638 1.00 97.30 ? 538 HIS A CB 1 ATOM 4162 C CG . HIS A 1 537 ? -9.790 -5.040 -8.312 1.00 112.26 ? 538 HIS A CG 1 ATOM 4163 N ND1 . HIS A 1 537 ? -8.481 -5.462 -8.201 1.00 125.72 ? 538 HIS A ND1 1 ATOM 4164 C CD2 . HIS A 1 537 ? -9.770 -3.956 -9.122 1.00 119.15 ? 538 HIS A CD2 1 ATOM 4165 C CE1 . HIS A 1 537 ? -7.701 -4.662 -8.904 1.00 135.01 ? 538 HIS A CE1 1 ATOM 4166 N NE2 . HIS A 1 537 ? -8.459 -3.739 -9.474 1.00 137.26 ? 538 HIS A NE2 1 ATOM 4167 N N . LYS A 1 538 ? -11.870 -6.275 -10.808 1.00 87.85 ? 539 LYS A N 1 ATOM 4168 C CA . LYS A 1 538 ? -12.632 -5.928 -12.022 1.00 78.79 ? 539 LYS A CA 1 ATOM 4169 C C . LYS A 1 538 ? -13.463 -7.108 -12.577 1.00 82.09 ? 539 LYS A C 1 ATOM 4170 O O . LYS A 1 538 ? -13.980 -7.055 -13.702 1.00 87.84 ? 539 LYS A O 1 ATOM 4171 C CB . LYS A 1 538 ? -11.699 -5.363 -13.089 1.00 73.93 ? 539 LYS A CB 1 ATOM 4172 C CG . LYS A 1 538 ? -11.054 -4.060 -12.682 1.00 73.12 ? 539 LYS A CG 1 ATOM 4173 C CD . LYS A 1 538 ? -11.159 -3.043 -13.791 1.00 74.27 ? 539 LYS A CD 1 ATOM 4174 C CE . LYS A 1 538 ? -11.026 -1.645 -13.221 1.00 83.36 ? 539 LYS A CE 1 ATOM 4175 N NZ . LYS A 1 538 ? -11.149 -0.600 -14.281 1.00 98.84 ? 539 LYS A NZ 1 ATOM 4176 N N . MET A 1 539 ? -13.590 -8.164 -11.773 1.00 76.78 ? 540 MET A N 1 ATOM 4177 C CA . MET A 1 539 ? -14.503 -9.273 -12.039 1.00 83.61 ? 540 MET A CA 1 ATOM 4178 C C . MET A 1 539 ? -15.347 -9.606 -10.823 1.00 83.67 ? 540 MET A C 1 ATOM 4179 O O . MET A 1 539 ? -14.953 -9.350 -9.692 1.00 87.12 ? 540 MET A O 1 ATOM 4180 C CB . MET A 1 539 ? -13.751 -10.554 -12.386 1.00 95.61 ? 540 MET A CB 1 ATOM 4181 C CG . MET A 1 539 ? -12.891 -10.508 -13.623 1.00 103.06 ? 540 MET A CG 1 ATOM 4182 S SD . MET A 1 539 ? -11.786 -11.923 -13.584 1.00 93.11 ? 540 MET A SD 1 ATOM 4183 C CE . MET A 1 539 ? -10.420 -11.234 -14.521 1.00 88.17 ? 540 MET A CE 1 ATOM 4184 N N . ILE A 1 540 ? -16.492 -10.225 -11.066 1.00 80.81 ? 541 ILE A N 1 ATOM 4185 C CA . ILE A 1 540 ? -17.308 -10.744 -10.000 1.00 78.04 ? 541 ILE A CA 1 ATOM 4186 C C . ILE A 1 540 ? -17.800 -12.135 -10.434 1.00 75.63 ? 541 ILE A C 1 ATOM 4187 O O . ILE A 1 540 ? -17.818 -12.435 -11.626 1.00 70.47 ? 541 ILE A O 1 ATOM 4188 C CB . ILE A 1 540 ? -18.377 -9.684 -9.568 1.00 80.90 ? 541 ILE A CB 1 ATOM 4189 C CG1 . ILE A 1 540 ? -18.561 -9.667 -8.030 1.00 90.86 ? 541 ILE A CG1 1 ATOM 4190 C CG2 . ILE A 1 540 ? -19.685 -9.790 -10.356 1.00 72.99 ? 541 ILE A CG2 1 ATOM 4191 C CD1 . ILE A 1 540 ? -17.543 -8.860 -7.214 1.00 85.90 ? 541 ILE A CD1 1 ATOM 4192 N N . CYS A 1 541 ? -18.138 -12.984 -9.464 1.00 75.91 ? 542 CYS A N 1 ATOM 4193 C CA . CYS A 1 541 ? -18.446 -14.412 -9.692 1.00 78.19 ? 542 CYS A CA 1 ATOM 4194 C C . CYS A 1 541 ? -19.844 -14.841 -9.267 1.00 78.62 ? 542 CYS A C 1 ATOM 4195 O O . CYS A 1 541 ? -20.489 -14.134 -8.499 1.00 86.95 ? 542 CYS A O 1 ATOM 4196 C CB . CYS A 1 541 ? -17.493 -15.226 -8.864 1.00 84.72 ? 542 CYS A CB 1 ATOM 4197 S SG . CYS A 1 541 ? -15.936 -15.559 -9.665 1.00 117.27 ? 542 CYS A SG 1 ATOM 4198 N N . ALA A 1 542 ? -20.303 -16.013 -9.715 1.00 79.47 ? 543 ALA A N 1 ATOM 4199 C CA . ALA A 1 542 ? -21.636 -16.547 -9.309 1.00 86.17 ? 543 ALA A CA 1 ATOM 4200 C C . ALA A 1 542 ? -21.934 -17.993 -9.739 1.00 92.38 ? 543 ALA A C 1 ATOM 4201 O O . ALA A 1 542 ? -21.403 -18.438 -10.755 1.00 96.67 ? 543 ALA A O 1 ATOM 4202 C CB . ALA A 1 542 ? -22.742 -15.636 -9.813 1.00 73.95 ? 543 ALA A CB 1 ATOM 4203 N N . GLY A 1 543 ? -22.799 -18.701 -8.993 1.00 96.81 ? 544 GLY A N 1 ATOM 4204 C CA . GLY A 1 543 ? -23.225 -20.060 -9.381 1.00 103.28 ? 544 GLY A CA 1 ATOM 4205 C C . GLY A 1 543 ? -23.953 -20.996 -8.418 1.00 115.32 ? 544 GLY A C 1 ATOM 4206 O O . GLY A 1 543 ? -24.242 -20.640 -7.262 1.00 107.62 ? 544 GLY A O 1 ATOM 4207 N N . TYR A 1 544 ? -24.214 -22.208 -8.936 1.00 127.64 ? 545 TYR A N 1 ATOM 4208 C CA . TYR A 1 544 ? -24.946 -23.354 -8.307 1.00 132.47 ? 545 TYR A CA 1 ATOM 4209 C C . TYR A 1 544 ? -26.476 -23.204 -8.275 1.00 130.78 ? 545 TYR A C 1 ATOM 4210 O O . TYR A 1 544 ? -27.025 -22.262 -7.699 1.00 122.64 ? 545 TYR A O 1 ATOM 4211 C CB . TYR A 1 544 ? -24.397 -23.812 -6.926 1.00 131.27 ? 545 TYR A CB 1 ATOM 4212 C CG . TYR A 1 544 ? -22.932 -23.501 -6.616 1.00 140.09 ? 545 TYR A CG 1 ATOM 4213 C CD1 . TYR A 1 544 ? -21.905 -23.765 -7.548 1.00 142.28 ? 545 TYR A CD1 1 ATOM 4214 C CD2 . TYR A 1 544 ? -22.566 -22.952 -5.369 1.00 131.83 ? 545 TYR A CD2 1 ATOM 4215 C CE1 . TYR A 1 544 ? -20.574 -23.466 -7.257 1.00 131.34 ? 545 TYR A CE1 1 ATOM 4216 C CE2 . TYR A 1 544 ? -21.233 -22.664 -5.066 1.00 117.35 ? 545 TYR A CE2 1 ATOM 4217 C CZ . TYR A 1 544 ? -20.247 -22.922 -6.011 1.00 122.16 ? 545 TYR A CZ 1 ATOM 4218 O OH . TYR A 1 544 ? -18.934 -22.647 -5.726 1.00 115.11 ? 545 TYR A OH 1 ATOM 4219 N N . LYS A 1 553 ? -26.751 -20.760 -17.485 1.00 87.02 ? 554 LYS A N 1 ATOM 4220 C CA . LYS A 1 553 ? -27.908 -20.982 -18.364 1.00 100.45 ? 554 LYS A CA 1 ATOM 4221 C C . LYS A 1 553 ? -28.215 -19.776 -19.318 1.00 103.69 ? 554 LYS A C 1 ATOM 4222 O O . LYS A 1 553 ? -29.319 -19.659 -19.898 1.00 98.59 ? 554 LYS A O 1 ATOM 4223 C CB . LYS A 1 553 ? -29.140 -21.368 -17.521 1.00 112.53 ? 554 LYS A CB 1 ATOM 4224 C CG . LYS A 1 553 ? -28.857 -22.285 -16.327 1.00 117.64 ? 554 LYS A CG 1 ATOM 4225 C CD . LYS A 1 553 ? -30.132 -22.936 -15.801 1.00 120.04 ? 554 LYS A CD 1 ATOM 4226 C CE . LYS A 1 553 ? -30.443 -24.231 -16.546 1.00 123.93 ? 554 LYS A CE 1 ATOM 4227 N NZ . LYS A 1 553 ? -31.905 -24.415 -16.756 1.00 121.93 ? 554 LYS A NZ 1 ATOM 4228 N N . GLY A 1 554 ? -27.224 -18.892 -19.466 1.00 100.01 ? 555 GLY A N 1 ATOM 4229 C CA . GLY A 1 554 ? -27.275 -17.747 -20.390 1.00 96.83 ? 555 GLY A CA 1 ATOM 4230 C C . GLY A 1 554 ? -26.036 -17.596 -21.293 1.00 94.97 ? 555 GLY A C 1 ATOM 4231 O O . GLY A 1 554 ? -25.047 -18.344 -21.160 1.00 100.24 ? 555 GLY A O 1 ATOM 4232 N N . ASP A 1 555 ? -26.083 -16.603 -22.186 1.00 78.22 ? 556 ASP A N 1 ATOM 4233 C CA . ASP A 1 555 ? -25.098 -16.419 -23.256 1.00 69.43 ? 556 ASP A CA 1 ATOM 4234 C C . ASP A 1 555 ? -23.872 -15.596 -22.893 1.00 69.47 ? 556 ASP A C 1 ATOM 4235 O O . ASP A 1 555 ? -23.759 -15.028 -21.809 1.00 66.75 ? 556 ASP A O 1 ATOM 4236 C CB . ASP A 1 555 ? -25.741 -15.762 -24.485 1.00 73.33 ? 556 ASP A CB 1 ATOM 4237 C CG . ASP A 1 555 ? -27.246 -15.784 -24.444 1.00 77.97 ? 556 ASP A CG 1 ATOM 4238 O OD1 . ASP A 1 555 ? -27.828 -14.839 -23.867 1.00 92.71 ? 556 ASP A OD1 1 ATOM 4239 O OD2 . ASP A 1 555 ? -27.843 -16.731 -24.995 1.00 78.61 ? 556 ASP A OD2 1 ATOM 4240 N N . SER A 1 556 ? -22.948 -15.531 -23.841 1.00 76.05 ? 557 SER A N 1 ATOM 4241 C CA . SER A 1 556 ? -21.878 -14.547 -23.813 1.00 79.30 ? 557 SER A CA 1 ATOM 4242 C C . SER A 1 556 ? -22.498 -13.165 -23.880 1.00 74.92 ? 557 SER A C 1 ATOM 4243 O O . SER A 1 556 ? -23.442 -12.959 -24.640 1.00 73.90 ? 557 SER A O 1 ATOM 4244 C CB . SER A 1 556 ? -20.945 -14.755 -25.006 1.00 81.67 ? 557 SER A CB 1 ATOM 4245 O OG . SER A 1 556 ? -19.841 -15.569 -24.658 1.00 72.46 ? 557 SER A OG 1 ATOM 4246 N N . GLY A 1 557 ? -21.988 -12.242 -23.065 1.00 76.93 ? 558 GLY A N 1 ATOM 4247 C CA . GLY A 1 557 ? -22.460 -10.849 -23.044 1.00 76.38 ? 558 GLY A CA 1 ATOM 4248 C C . GLY A 1 557 ? -23.763 -10.621 -22.299 1.00 77.15 ? 558 GLY A C 1 ATOM 4249 O O . GLY A 1 557 ? -24.185 -9.468 -22.105 1.00 79.85 ? 558 GLY A O 1 ATOM 4250 N N . GLY A 1 558 ? -24.399 -11.729 -21.901 1.00 74.98 ? 559 GLY A N 1 ATOM 4251 C CA . GLY A 1 558 ? -25.655 -11.735 -21.166 1.00 69.20 ? 559 GLY A CA 1 ATOM 4252 C C . GLY A 1 558 ? -25.556 -11.063 -19.802 1.00 68.40 ? 559 GLY A C 1 ATOM 4253 O O . GLY A 1 558 ? -24.484 -11.030 -19.178 1.00 70.16 ? 559 GLY A O 1 ATOM 4254 N N . PRO A 1 559 ? -26.681 -10.529 -19.322 1.00 64.38 ? 560 PRO A N 1 ATOM 4255 C CA . PRO A 1 559 ? -26.681 -9.748 -18.114 1.00 63.13 ? 560 PRO A CA 1 ATOM 4256 C C . PRO A 1 559 ? -26.719 -10.588 -16.860 1.00 61.22 ? 560 PRO A C 1 ATOM 4257 O O . PRO A 1 559 ? -27.422 -11.609 -16.815 1.00 65.59 ? 560 PRO A O 1 ATOM 4258 C CB . PRO A 1 559 ? -27.999 -8.982 -18.219 1.00 66.65 ? 560 PRO A CB 1 ATOM 4259 C CG . PRO A 1 559 ? -28.912 -9.921 -18.931 1.00 62.80 ? 560 PRO A CG 1 ATOM 4260 C CD . PRO A 1 559 ? -28.029 -10.635 -19.912 1.00 65.27 ? 560 PRO A CD 1 ATOM 4261 N N . LEU A 1 560 ? -25.977 -10.131 -15.854 1.00 61.14 ? 561 LEU A N 1 ATOM 4262 C CA . LEU A 1 560 ? -26.225 -10.474 -14.455 1.00 62.01 ? 561 LEU A CA 1 ATOM 4263 C C . LEU A 1 560 ? -27.063 -9.379 -13.729 1.00 64.91 ? 561 LEU A C 1 ATOM 4264 O O . LEU A 1 560 ? -26.538 -8.337 -13.254 1.00 58.25 ? 561 LEU A O 1 ATOM 4265 C CB . LEU A 1 560 ? -24.910 -10.800 -13.728 1.00 59.55 ? 561 LEU A CB 1 ATOM 4266 C CG . LEU A 1 560 ? -25.012 -11.283 -12.266 1.00 59.88 ? 561 LEU A CG 1 ATOM 4267 C CD1 . LEU A 1 560 ? -25.920 -12.503 -12.057 1.00 53.76 ? 561 LEU A CD1 1 ATOM 4268 C CD2 . LEU A 1 560 ? -23.620 -11.513 -11.695 1.00 52.94 ? 561 LEU A CD2 1 ATOM 4269 N N . SER A 1 561 ? -28.374 -9.631 -13.663 1.00 64.76 ? 562 SER A N 1 ATOM 4270 C CA . SER A 1 561 ? -29.324 -8.650 -13.146 1.00 64.26 ? 562 SER A CA 1 ATOM 4271 C C . SER A 1 561 ? -29.668 -8.920 -11.699 1.00 68.67 ? 562 SER A C 1 ATOM 4272 O O . SER A 1 561 ? -30.163 -10.009 -11.379 1.00 69.02 ? 562 SER A O 1 ATOM 4273 C CB . SER A 1 561 ? -30.604 -8.650 -13.975 1.00 62.73 ? 562 SER A CB 1 ATOM 4274 O OG . SER A 1 561 ? -30.359 -8.339 -15.335 1.00 66.41 ? 562 SER A OG 1 ATOM 4275 N N . CYS A 1 562 ? -29.408 -7.936 -10.833 1.00 71.65 ? 563 CYS A N 1 ATOM 4276 C CA . CYS A 1 562 ? -29.851 -7.985 -9.426 1.00 72.55 ? 563 CYS A CA 1 ATOM 4277 C C . CYS A 1 562 ? -30.979 -6.992 -9.078 1.00 74.15 ? 563 CYS A C 1 ATOM 4278 O O . CYS A 1 562 ? -30.902 -5.808 -9.423 1.00 69.30 ? 563 CYS A O 1 ATOM 4279 C CB . CYS A 1 562 ? -28.662 -7.834 -8.483 1.00 70.92 ? 563 CYS A CB 1 ATOM 4280 S SG . CYS A 1 562 ? -27.328 -8.999 -8.877 1.00 88.33 ? 563 CYS A SG 1 ATOM 4281 N N . LYS A 1 563 ? -32.036 -7.494 -8.426 1.00 75.82 ? 564 LYS A N 1 ATOM 4282 C CA . LYS A 1 563 ? -33.118 -6.651 -7.882 1.00 66.38 ? 564 LYS A CA 1 ATOM 4283 C C . LYS A 1 563 ? -32.761 -6.231 -6.468 1.00 68.78 ? 564 LYS A C 1 ATOM 4284 O O . LYS A 1 563 ? -32.375 -7.054 -5.622 1.00 67.69 ? 564 LYS A O 1 ATOM 4285 C CB . LYS A 1 563 ? -34.463 -7.363 -7.885 1.00 62.08 ? 564 LYS A CB 1 ATOM 4286 C CG . LYS A 1 563 ? -35.644 -6.417 -7.805 1.00 69.13 ? 564 LYS A CG 1 ATOM 4287 C CD . LYS A 1 563 ? -36.982 -7.147 -7.798 1.00 70.72 ? 564 LYS A CD 1 ATOM 4288 C CE . LYS A 1 563 ? -38.077 -6.215 -8.296 1.00 83.13 ? 564 LYS A CE 1 ATOM 4289 N NZ . LYS A 1 563 ? -39.401 -6.880 -8.456 1.00 97.88 ? 564 LYS A NZ 1 ATOM 4290 N N . HIS A 1 564 ? -32.852 -4.927 -6.241 1.00 74.53 ? 565 HIS A N 1 ATOM 4291 C CA . HIS A 1 564 ? -32.511 -4.315 -4.970 1.00 72.48 ? 565 HIS A CA 1 ATOM 4292 C C . HIS A 1 564 ? -33.479 -3.169 -4.816 1.00 76.58 ? 565 HIS A C 1 ATOM 4293 O O . HIS A 1 564 ? -33.505 -2.273 -5.669 1.00 73.83 ? 565 HIS A O 1 ATOM 4294 C CB . HIS A 1 564 ? -31.073 -3.815 -4.985 1.00 71.78 ? 565 HIS A CB 1 ATOM 4295 C CG . HIS A 1 564 ? -30.573 -3.381 -3.644 1.00 82.40 ? 565 HIS A CG 1 ATOM 4296 N ND1 . HIS A 1 564 ? -29.888 -4.224 -2.795 1.00 90.03 ? 565 HIS A ND1 1 ATOM 4297 C CD2 . HIS A 1 564 ? -30.648 -2.190 -3.007 1.00 87.16 ? 565 HIS A CD2 1 ATOM 4298 C CE1 . HIS A 1 564 ? -29.574 -3.575 -1.688 1.00 91.23 ? 565 HIS A CE1 1 ATOM 4299 N NE2 . HIS A 1 564 ? -30.029 -2.339 -1.789 1.00 92.85 ? 565 HIS A NE2 1 ATOM 4300 N N . ASN A 1 565 ? -34.299 -3.234 -3.758 1.00 76.43 ? 566 ASN A N 1 ATOM 4301 C CA . ASN A 1 565 ? -35.319 -2.221 -3.456 1.00 78.14 ? 566 ASN A CA 1 ATOM 4302 C C . ASN A 1 565 ? -36.251 -2.014 -4.639 1.00 81.37 ? 566 ASN A C 1 ATOM 4303 O O . ASN A 1 565 ? -36.428 -0.894 -5.112 1.00 84.23 ? 566 ASN A O 1 ATOM 4304 C CB . ASN A 1 565 ? -34.667 -0.897 -3.010 1.00 74.85 ? 566 ASN A CB 1 ATOM 4305 C CG . ASN A 1 565 ? -33.556 -1.106 -1.994 1.00 84.05 ? 566 ASN A CG 1 ATOM 4306 O OD1 . ASN A 1 565 ? -33.396 -2.195 -1.447 1.00 88.66 ? 566 ASN A OD1 1 ATOM 4307 N ND2 . ASN A 1 565 ? -32.766 -0.069 -1.752 1.00 91.32 ? 566 ASN A ND2 1 ATOM 4308 N N . GLU A 1 566 ? -36.812 -3.119 -5.128 1.00 88.87 ? 567 GLU A N 1 ATOM 4309 C CA . GLU A 1 566 ? -37.667 -3.156 -6.340 1.00 98.91 ? 567 GLU A CA 1 ATOM 4310 C C . GLU A 1 566 ? -37.140 -2.402 -7.566 1.00 91.40 ? 567 GLU A C 1 ATOM 4311 O O . GLU A 1 566 ? -37.913 -1.828 -8.339 1.00 95.07 ? 567 GLU A O 1 ATOM 4312 C CB . GLU A 1 566 ? -39.101 -2.729 -6.021 1.00 108.74 ? 567 GLU A CB 1 ATOM 4313 C CG . GLU A 1 566 ? -39.877 -3.764 -5.232 1.00 115.38 ? 567 GLU A CG 1 ATOM 4314 C CD . GLU A 1 566 ? -40.347 -3.205 -3.908 1.00 121.42 ? 567 GLU A CD 1 ATOM 4315 O OE1 . GLU A 1 566 ? -40.534 -1.969 -3.813 1.00 119.74 ? 567 GLU A OE1 1 ATOM 4316 O OE2 . GLU A 1 566 ? -40.520 -3.996 -2.959 1.00 126.69 ? 567 GLU A OE2 1 ATOM 4317 N N . VAL A 1 567 ? -35.819 -2.389 -7.713 1.00 82.97 ? 568 VAL A N 1 ATOM 4318 C CA . VAL A 1 567 ? -35.151 -1.753 -8.842 1.00 76.15 ? 568 VAL A CA 1 ATOM 4319 C C . VAL A 1 567 ? -34.077 -2.730 -9.267 1.00 76.39 ? 568 VAL A C 1 ATOM 4320 O O . VAL A 1 567 ? -33.395 -3.308 -8.419 1.00 81.16 ? 568 VAL A O 1 ATOM 4321 C CB . VAL A 1 567 ? -34.508 -0.382 -8.491 1.00 74.71 ? 568 VAL A CB 1 ATOM 4322 C CG1 . VAL A 1 567 ? -33.983 0.315 -9.735 1.00 72.64 ? 568 VAL A CG1 1 ATOM 4323 C CG2 . VAL A 1 567 ? -35.496 0.549 -7.805 1.00 80.04 ? 568 VAL A CG2 1 ATOM 4324 N N . TRP A 1 568 ? -33.954 -2.904 -10.582 1.00 71.79 ? 569 TRP A N 1 ATOM 4325 C CA . TRP A 1 568 ? -33.049 -3.854 -11.203 1.00 67.34 ? 569 TRP A CA 1 ATOM 4326 C C . TRP A 1 568 ? -31.735 -3.228 -11.635 1.00 66.16 ? 569 TRP A C 1 ATOM 4327 O O . TRP A 1 568 ? -31.735 -2.231 -12.351 1.00 68.04 ? 569 TRP A O 1 ATOM 4328 C CB . TRP A 1 568 ? -33.710 -4.394 -12.443 1.00 66.52 ? 569 TRP A CB 1 ATOM 4329 C CG . TRP A 1 568 ? -34.717 -5.387 -12.187 1.00 66.89 ? 569 TRP A CG 1 ATOM 4330 C CD1 . TRP A 1 568 ? -36.062 -5.233 -12.297 1.00 68.54 ? 569 TRP A CD1 1 ATOM 4331 C CD2 . TRP A 1 568 ? -34.489 -6.735 -11.806 1.00 72.12 ? 569 TRP A CD2 1 ATOM 4332 N NE1 . TRP A 1 568 ? -36.706 -6.410 -11.993 1.00 69.52 ? 569 TRP A NE1 1 ATOM 4333 C CE2 . TRP A 1 568 ? -35.766 -7.355 -11.685 1.00 72.55 ? 569 TRP A CE2 1 ATOM 4334 C CE3 . TRP A 1 568 ? -33.332 -7.487 -11.533 1.00 70.98 ? 569 TRP A CE3 1 ATOM 4335 C CZ2 . TRP A 1 568 ? -35.923 -8.699 -11.309 1.00 70.93 ? 569 TRP A CZ2 1 ATOM 4336 C CZ3 . TRP A 1 568 ? -33.482 -8.826 -11.144 1.00 74.27 ? 569 TRP A CZ3 1 ATOM 4337 C CH2 . TRP A 1 568 ? -34.774 -9.418 -11.038 1.00 72.99 ? 569 TRP A CH2 1 ATOM 4338 N N . HIS A 1 569 ? -30.630 -3.852 -11.238 1.00 64.21 ? 570 HIS A N 1 ATOM 4339 C CA . HIS A 1 569 ? -29.291 -3.401 -11.589 1.00 62.59 ? 570 HIS A CA 1 ATOM 4340 C C . HIS A 1 569 ? -28.532 -4.380 -12.474 1.00 65.44 ? 570 HIS A C 1 ATOM 4341 O O . HIS A 1 569 ? -28.674 -5.600 -12.344 1.00 69.85 ? 570 HIS A O 1 ATOM 4342 C CB . HIS A 1 569 ? -28.487 -3.172 -10.335 1.00 67.27 ? 570 HIS A CB 1 ATOM 4343 C CG . HIS A 1 569 ? -29.219 -2.392 -9.299 1.00 75.31 ? 570 HIS A CG 1 ATOM 4344 N ND1 . HIS A 1 569 ? -29.300 -1.017 -9.325 1.00 77.69 ? 570 HIS A ND1 1 ATOM 4345 C CD2 . HIS A 1 569 ? -29.911 -2.794 -8.209 1.00 77.31 ? 570 HIS A CD2 1 ATOM 4346 C CE1 . HIS A 1 569 ? -30.010 -0.604 -8.293 1.00 82.51 ? 570 HIS A CE1 1 ATOM 4347 N NE2 . HIS A 1 569 ? -30.396 -1.664 -7.604 1.00 86.63 ? 570 HIS A NE2 1 ATOM 4348 N N . LEU A 1 570 ? -27.718 -3.837 -13.375 1.00 64.45 ? 571 LEU A N 1 ATOM 4349 C CA . LEU A 1 570 ? -26.829 -4.649 -14.191 1.00 62.25 ? 571 LEU A CA 1 ATOM 4350 C C . LEU A 1 570 ? -25.490 -4.796 -13.487 1.00 66.79 ? 571 LEU A C 1 ATOM 4351 O O . LEU A 1 570 ? -24.608 -3.953 -13.614 1.00 69.47 ? 571 LEU A O 1 ATOM 4352 C CB . LEU A 1 570 ? -26.646 -4.033 -15.572 1.00 55.54 ? 571 LEU A CB 1 ATOM 4353 C CG . LEU A 1 570 ? -25.829 -4.875 -16.537 1.00 49.52 ? 571 LEU A CG 1 ATOM 4354 C CD1 . LEU A 1 570 ? -26.385 -6.293 -16.541 1.00 52.04 ? 571 LEU A CD1 1 ATOM 4355 C CD2 . LEU A 1 570 ? -25.890 -4.253 -17.918 1.00 45.40 ? 571 LEU A CD2 1 ATOM 4356 N N . VAL A 1 571 ? -25.343 -5.887 -12.757 1.00 65.20 ? 572 VAL A N 1 ATOM 4357 C CA . VAL A 1 571 ? -24.228 -6.027 -11.839 1.00 61.28 ? 572 VAL A CA 1 ATOM 4358 C C . VAL A 1 571 ? -23.043 -6.636 -12.577 1.00 59.99 ? 572 VAL A C 1 ATOM 4359 O O . VAL A 1 571 ? -21.899 -6.208 -12.381 1.00 59.47 ? 572 VAL A O 1 ATOM 4360 C CB . VAL A 1 571 ? -24.685 -6.820 -10.593 1.00 68.17 ? 572 VAL A CB 1 ATOM 4361 C CG1 . VAL A 1 571 ? -23.534 -7.186 -9.680 1.00 71.36 ? 572 VAL A CG1 1 ATOM 4362 C CG2 . VAL A 1 571 ? -25.704 -6.000 -9.816 1.00 71.94 ? 572 VAL A CG2 1 ATOM 4363 N N . GLY A 1 572 ? -23.331 -7.599 -13.455 1.00 61.48 ? 573 GLY A N 1 ATOM 4364 C CA . GLY A 1 572 ? -22.294 -8.288 -14.209 1.00 63.79 ? 573 GLY A CA 1 ATOM 4365 C C . GLY A 1 572 ? -22.681 -8.592 -15.629 1.00 65.09 ? 573 GLY A C 1 ATOM 4366 O O . GLY A 1 572 ? -23.856 -8.600 -15.950 1.00 64.37 ? 573 GLY A O 1 ATOM 4367 N N . ILE A 1 573 ? -21.669 -8.808 -16.475 1.00 74.69 ? 574 ILE A N 1 ATOM 4368 C CA . ILE A 1 573 ? -21.822 -9.265 -17.885 1.00 71.55 ? 574 ILE A CA 1 ATOM 4369 C C . ILE A 1 573 ? -21.099 -10.595 -17.975 1.00 68.96 ? 574 ILE A C 1 ATOM 4370 O O . ILE A 1 573 ? -19.977 -10.694 -17.452 1.00 76.85 ? 574 ILE A O 1 ATOM 4371 C CB . ILE A 1 573 ? -21.128 -8.304 -18.889 1.00 62.47 ? 574 ILE A CB 1 ATOM 4372 C CG1 . ILE A 1 573 ? -21.655 -6.885 -18.746 1.00 54.96 ? 574 ILE A CG1 1 ATOM 4373 C CG2 . ILE A 1 573 ? -21.267 -8.792 -20.328 1.00 57.67 ? 574 ILE A CG2 1 ATOM 4374 C CD1 . ILE A 1 573 ? -20.652 -5.859 -19.198 1.00 53.03 ? 574 ILE A CD1 1 ATOM 4375 N N . THR A 1 574 ? -21.699 -11.587 -18.642 1.00 62.83 ? 575 THR A N 1 ATOM 4376 C CA . THR A 1 574 ? -21.071 -12.926 -18.778 1.00 71.29 ? 575 THR A CA 1 ATOM 4377 C C . THR A 1 574 ? -19.715 -12.923 -19.508 1.00 73.15 ? 575 THR A C 1 ATOM 4378 O O . THR A 1 574 ? -19.562 -12.307 -20.559 1.00 79.89 ? 575 THR A O 1 ATOM 4379 C CB . THR A 1 574 ? -21.990 -13.979 -19.434 1.00 71.70 ? 575 THR A CB 1 ATOM 4380 O OG1 . THR A 1 574 ? -23.349 -13.774 -19.033 1.00 69.40 ? 575 THR A OG1 1 ATOM 4381 C CG2 . THR A 1 574 ? -21.571 -15.381 -19.016 1.00 74.55 ? 575 THR A CG2 1 ATOM 4382 N N . SER A 1 575 ? -18.757 -13.632 -18.916 1.00 76.95 ? 576 SER A N 1 ATOM 4383 C CA . SER A 1 575 ? -17.373 -13.721 -19.353 1.00 85.23 ? 576 SER A CA 1 ATOM 4384 C C . SER A 1 575 ? -16.911 -15.125 -18.897 1.00 108.38 ? 576 SER A C 1 ATOM 4385 O O . SER A 1 575 ? -16.864 -15.408 -17.695 1.00 137.32 ? 576 SER A O 1 ATOM 4386 C CB . SER A 1 575 ? -16.574 -12.619 -18.648 1.00 75.33 ? 576 SER A CB 1 ATOM 4387 O OG . SER A 1 575 ? -15.425 -12.230 -19.364 1.00 80.72 ? 576 SER A OG 1 ATOM 4388 N N . TRP A 1 576 ? -16.571 -16.008 -19.837 1.00 113.91 ? 577 TRP A N 1 ATOM 4389 C CA . TRP A 1 576 ? -16.146 -17.419 -19.536 1.00 116.79 ? 577 TRP A CA 1 ATOM 4390 C C . TRP A 1 576 ? -17.057 -18.282 -18.623 1.00 111.70 ? 577 TRP A C 1 ATOM 4391 O O . TRP A 1 576 ? -18.283 -18.254 -18.771 1.00 122.31 ? 577 TRP A O 1 ATOM 4392 C CB . TRP A 1 576 ? -14.643 -17.559 -19.161 1.00 106.25 ? 577 TRP A CB 1 ATOM 4393 C CG . TRP A 1 576 ? -13.950 -16.435 -18.413 1.00 92.14 ? 577 TRP A CG 1 ATOM 4394 C CD1 . TRP A 1 576 ? -13.923 -15.101 -18.742 1.00 94.32 ? 577 TRP A CD1 1 ATOM 4395 C CD2 . TRP A 1 576 ? -13.093 -16.577 -17.277 1.00 91.13 ? 577 TRP A CD2 1 ATOM 4396 N NE1 . TRP A 1 576 ? -13.156 -14.397 -17.843 1.00 97.39 ? 577 TRP A NE1 1 ATOM 4397 C CE2 . TRP A 1 576 ? -12.617 -15.277 -16.942 1.00 90.17 ? 577 TRP A CE2 1 ATOM 4398 C CE3 . TRP A 1 576 ? -12.678 -17.674 -16.501 1.00 84.21 ? 577 TRP A CE3 1 ATOM 4399 C CZ2 . TRP A 1 576 ? -11.755 -15.043 -15.862 1.00 81.05 ? 577 TRP A CZ2 1 ATOM 4400 C CZ3 . TRP A 1 576 ? -11.806 -17.440 -15.422 1.00 80.49 ? 577 TRP A CZ3 1 ATOM 4401 C CH2 . TRP A 1 576 ? -11.365 -16.130 -15.112 1.00 79.20 ? 577 TRP A CH2 1 ATOM 4402 N N . GLY A 1 577 ? -16.458 -19.067 -17.726 1.00 103.28 ? 578 GLY A N 1 ATOM 4403 C CA . GLY A 1 577 ? -17.218 -19.879 -16.777 1.00 101.17 ? 578 GLY A CA 1 ATOM 4404 C C . GLY A 1 577 ? -17.093 -21.365 -16.998 1.00 97.57 ? 578 GLY A C 1 ATOM 4405 O O . GLY A 1 577 ? -15.993 -21.904 -16.927 1.00 108.70 ? 578 GLY A O 1 ATOM 4406 N N . GLU A 1 578 ? -17.349 -22.401 -16.475 0.00 116.78 ? 579 GLU A N 1 ATOM 4407 C CA . GLU A 1 578 ? -17.113 -23.826 -16.699 0.00 120.08 ? 579 GLU A CA 1 ATOM 4408 C C . GLU A 1 578 ? -18.319 -24.589 -16.185 0.00 122.36 ? 579 GLU A C 1 ATOM 4409 O O . GLU A 1 578 ? -18.961 -24.163 -15.236 0.00 123.93 ? 579 GLU A O 1 ATOM 4410 C CB . GLU A 1 578 ? -15.858 -24.309 -15.971 0.00 120.89 ? 579 GLU A CB 1 ATOM 4411 C CG . GLU A 1 578 ? -14.635 -23.435 -16.173 0.00 120.64 ? 579 GLU A CG 1 ATOM 4412 C CD . GLU A 1 578 ? -13.853 -23.769 -17.426 0.00 120.04 ? 579 GLU A CD 1 ATOM 4413 O OE1 . GLU A 1 578 ? -13.912 -24.930 -17.876 0.00 122.35 ? 579 GLU A OE1 1 ATOM 4414 O OE2 . GLU A 1 578 ? -13.164 -22.871 -17.949 0.00 119.13 ? 579 GLU A OE2 1 ATOM 4415 N N . GLY A 1 579 ? -18.313 -24.351 -16.388 1.00 114.94 ? 580 GLY A N 1 ATOM 4416 C CA . GLY A 1 579 ? -19.122 -25.418 -16.973 1.00 123.67 ? 580 GLY A CA 1 ATOM 4417 C C . GLY A 1 579 ? -20.511 -25.488 -16.364 1.00 129.84 ? 580 GLY A C 1 ATOM 4418 O O . GLY A 1 579 ? -20.665 -25.954 -15.228 1.00 133.15 ? 580 GLY A O 1 ATOM 4419 N N . CYS A 1 580 ? -21.504 -25.047 -17.147 1.00 130.90 ? 581 CYS A N 1 ATOM 4420 C CA . CYS A 1 580 ? -22.926 -24.854 -16.750 1.00 136.37 ? 581 CYS A CA 1 ATOM 4421 C C . CYS A 1 580 ? -23.361 -25.348 -15.355 1.00 140.15 ? 581 CYS A C 1 ATOM 4422 O O . CYS A 1 580 ? -24.223 -24.744 -14.704 1.00 137.45 ? 581 CYS A O 1 ATOM 4423 C CB . CYS A 1 580 ? -23.874 -25.407 -17.831 1.00 126.14 ? 581 CYS A CB 1 ATOM 4424 S SG . CYS A 1 580 ? -25.557 -24.730 -17.753 1.00 135.20 ? 581 CYS A SG 1 ATOM 4425 N N . GLU A 1 584 ? -19.739 -28.686 -11.001 1.00 108.63 ? 585 GLU A N 1 ATOM 4426 C CA . GLU A 1 584 ? -20.213 -27.321 -10.826 1.00 116.62 ? 585 GLU A CA 1 ATOM 4427 C C . GLU A 1 584 ? -19.122 -26.357 -10.349 1.00 117.74 ? 585 GLU A C 1 ATOM 4428 O O . GLU A 1 584 ? -18.608 -26.494 -9.227 1.00 112.12 ? 585 GLU A O 1 ATOM 4429 C CB . GLU A 1 584 ? -21.380 -27.291 -9.843 1.00 128.29 ? 585 GLU A CB 1 ATOM 4430 C CG . GLU A 1 584 ? -22.716 -27.727 -10.424 1.00 140.95 ? 585 GLU A CG 1 ATOM 4431 C CD . GLU A 1 584 ? -23.899 -27.110 -9.690 1.00 148.38 ? 585 GLU A CD 1 ATOM 4432 O OE1 . GLU A 1 584 ? -23.827 -26.909 -8.450 1.00 147.89 ? 585 GLU A OE1 1 ATOM 4433 O OE2 . GLU A 1 584 ? -24.909 -26.821 -10.362 1.00 141.43 ? 585 GLU A OE2 1 ATOM 4434 N N . ARG A 1 585 ? -18.772 -25.404 -11.225 1.00 119.29 ? 586 ARG A N 1 ATOM 4435 C CA . ARG A 1 585 ? -17.935 -24.225 -10.902 1.00 114.04 ? 586 ARG A CA 1 ATOM 4436 C C . ARG A 1 585 ? -18.657 -22.928 -11.262 1.00 111.02 ? 586 ARG A C 1 ATOM 4437 O O . ARG A 1 585 ? -19.348 -22.875 -12.279 1.00 99.43 ? 586 ARG A O 1 ATOM 4438 C CB . ARG A 1 585 ? -16.587 -24.227 -11.642 1.00 116.78 ? 586 ARG A CB 1 ATOM 4439 C CG . ARG A 1 585 ? -15.456 -24.957 -10.924 1.00 119.40 ? 586 ARG A CG 1 ATOM 4440 C CD . ARG A 1 585 ? -15.151 -26.326 -11.566 1.00 132.09 ? 586 ARG A CD 1 ATOM 4441 N NE . ARG A 1 585 ? -16.347 -26.920 -12.202 1.00 139.33 ? 586 ARG A NE 1 ATOM 4442 C CZ . ARG A 1 585 ? -16.372 -28.054 -12.907 1.00 140.61 ? 586 ARG A CZ 1 ATOM 4443 N NH1 . ARG A 1 585 ? -15.258 -28.775 -13.082 1.00 151.21 ? 586 ARG A NH1 1 ATOM 4444 N NH2 . ARG A 1 585 ? -17.526 -28.469 -13.438 1.00 127.82 ? 586 ARG A NH2 1 ATOM 4445 N N . PRO A 1 586 ? -18.476 -21.871 -10.442 1.00 122.54 ? 587 PRO A N 1 ATOM 4446 C CA . PRO A 1 586 ? -19.042 -20.530 -10.695 1.00 116.66 ? 587 PRO A CA 1 ATOM 4447 C C . PRO A 1 586 ? -18.552 -19.830 -11.971 1.00 103.16 ? 587 PRO A C 1 ATOM 4448 O O . PRO A 1 586 ? -17.363 -19.888 -12.293 1.00 111.95 ? 587 PRO A O 1 ATOM 4449 C CB . PRO A 1 586 ? -18.597 -19.719 -9.462 1.00 125.00 ? 587 PRO A CB 1 ATOM 4450 C CG . PRO A 1 586 ? -17.442 -20.479 -8.895 1.00 136.78 ? 587 PRO A CG 1 ATOM 4451 C CD . PRO A 1 586 ? -17.791 -21.918 -9.134 1.00 133.21 ? 587 PRO A CD 1 ATOM 4452 N N . GLY A 1 587 ? -19.469 -19.160 -12.670 1.00 83.37 ? 588 GLY A N 1 ATOM 4453 C CA . GLY A 1 587 ? -19.128 -18.318 -13.818 1.00 69.58 ? 588 GLY A CA 1 ATOM 4454 C C . GLY A 1 587 ? -18.449 -17.027 -13.407 1.00 66.51 ? 588 GLY A C 1 ATOM 4455 O O . GLY A 1 587 ? -18.795 -16.441 -12.381 1.00 72.84 ? 588 GLY A O 1 ATOM 4456 N N . VAL A 1 588 ? -17.471 -16.583 -14.193 1.00 62.72 ? 589 VAL A N 1 ATOM 4457 C CA . VAL A 1 588 ? -16.859 -15.258 -13.990 1.00 62.57 ? 589 VAL A CA 1 ATOM 4458 C C . VAL A 1 588 ? -17.585 -14.180 -14.802 1.00 64.01 ? 589 VAL A C 1 ATOM 4459 O O . VAL A 1 588 ? -18.227 -14.480 -15.798 1.00 72.63 ? 589 VAL A O 1 ATOM 4460 C CB . VAL A 1 588 ? -15.370 -15.290 -14.304 1.00 62.03 ? 589 VAL A CB 1 ATOM 4461 C CG1 . VAL A 1 588 ? -14.664 -14.029 -13.778 1.00 58.10 ? 589 VAL A CG1 1 ATOM 4462 C CG2 . VAL A 1 588 ? -14.799 -16.552 -13.680 1.00 62.32 ? 589 VAL A CG2 1 ATOM 4463 N N . TYR A 1 589 ? -17.542 -12.941 -14.336 1.00 61.98 ? 590 TYR A N 1 ATOM 4464 C CA . TYR A 1 589 ? -18.360 -11.885 -14.907 1.00 61.35 ? 590 TYR A CA 1 ATOM 4465 C C . TYR A 1 589 ? -17.574 -10.603 -14.954 1.00 64.71 ? 590 TYR A C 1 ATOM 4466 O O . TYR A 1 589 ? -16.617 -10.445 -14.201 1.00 70.41 ? 590 TYR A O 1 ATOM 4467 C CB . TYR A 1 589 ? -19.629 -11.697 -14.070 1.00 58.39 ? 590 TYR A CB 1 ATOM 4468 C CG . TYR A 1 589 ? -20.649 -12.799 -14.268 1.00 57.87 ? 590 TYR A CG 1 ATOM 4469 C CD1 . TYR A 1 589 ? -20.527 -14.032 -13.613 1.00 59.13 ? 590 TYR A CD1 1 ATOM 4470 C CD2 . TYR A 1 589 ? -21.745 -12.613 -15.113 1.00 61.03 ? 590 TYR A CD2 1 ATOM 4471 C CE1 . TYR A 1 589 ? -21.454 -15.056 -13.810 1.00 56.74 ? 590 TYR A CE1 1 ATOM 4472 C CE2 . TYR A 1 589 ? -22.685 -13.621 -15.303 1.00 60.47 ? 590 TYR A CE2 1 ATOM 4473 C CZ . TYR A 1 589 ? -22.533 -14.836 -14.647 1.00 57.99 ? 590 TYR A CZ 1 ATOM 4474 O OH . TYR A 1 589 ? -23.454 -15.832 -14.850 1.00 54.56 ? 590 TYR A OH 1 ATOM 4475 N N . THR A 1 590 ? -17.949 -9.687 -15.837 1.00 64.44 ? 591 THR A N 1 ATOM 4476 C CA . THR A 1 590 ? -17.316 -8.385 -15.793 1.00 70.17 ? 591 THR A CA 1 ATOM 4477 C C . THR A 1 590 ? -18.001 -7.581 -14.690 1.00 75.46 ? 591 THR A C 1 ATOM 4478 O O . THR A 1 590 ? -19.245 -7.525 -14.608 1.00 75.93 ? 591 THR A O 1 ATOM 4479 C CB . THR A 1 590 ? -17.350 -7.656 -17.139 1.00 70.64 ? 591 THR A CB 1 ATOM 4480 O OG1 . THR A 1 590 ? -16.867 -8.523 -18.174 1.00 76.00 ? 591 THR A OG1 1 ATOM 4481 C CG2 . THR A 1 590 ? -16.450 -6.477 -17.077 1.00 66.29 ? 591 THR A CG2 1 ATOM 4482 N N . ASN A 1 591 ? -17.176 -6.997 -13.828 1.00 67.21 ? 592 ASN A N 1 ATOM 4483 C CA . ASN A 1 591 ? -17.669 -6.193 -12.714 1.00 70.95 ? 592 ASN A CA 1 ATOM 4484 C C . ASN A 1 591 ? -18.142 -4.764 -13.121 1.00 64.84 ? 592 ASN A C 1 ATOM 4485 O O . ASN A 1 591 ? -17.373 -3.795 -13.051 1.00 63.21 ? 592 ASN A O 1 ATOM 4486 C CB . ASN A 1 591 ? -16.589 -6.143 -11.633 1.00 73.92 ? 592 ASN A CB 1 ATOM 4487 C CG . ASN A 1 591 ? -17.138 -5.836 -10.259 1.00 78.26 ? 592 ASN A CG 1 ATOM 4488 O OD1 . ASN A 1 591 ? -18.301 -5.442 -10.093 1.00 77.01 ? 592 ASN A OD1 1 ATOM 4489 N ND2 . ASN A 1 591 ? -16.289 -6.008 -9.252 1.00 82.74 ? 592 ASN A ND2 1 ATOM 4490 N N . VAL A 1 592 ? -19.411 -4.638 -13.509 1.00 53.64 ? 593 VAL A N 1 ATOM 4491 C CA . VAL A 1 592 ? -19.900 -3.406 -14.148 1.00 50.15 ? 593 VAL A CA 1 ATOM 4492 C C . VAL A 1 592 ? -19.629 -2.117 -13.368 1.00 50.25 ? 593 VAL A C 1 ATOM 4493 O O . VAL A 1 592 ? -19.166 -1.141 -13.945 1.00 51.08 ? 593 VAL A O 1 ATOM 4494 C CB . VAL A 1 592 ? -21.386 -3.484 -14.555 1.00 50.02 ? 593 VAL A CB 1 ATOM 4495 C CG1 . VAL A 1 592 ? -21.756 -2.288 -15.393 1.00 48.59 ? 593 VAL A CG1 1 ATOM 4496 C CG2 . VAL A 1 592 ? -21.686 -4.739 -15.359 1.00 50.28 ? 593 VAL A CG2 1 ATOM 4497 N N . VAL A 1 593 ? -19.892 -2.123 -12.065 1.00 58.00 ? 594 VAL A N 1 ATOM 4498 C CA . VAL A 1 593 ? -19.520 -1.003 -11.171 1.00 60.26 ? 594 VAL A CA 1 ATOM 4499 C C . VAL A 1 593 ? -18.117 -0.435 -11.440 1.00 63.28 ? 594 VAL A C 1 ATOM 4500 O O . VAL A 1 593 ? -17.980 0.787 -11.609 1.00 62.88 ? 594 VAL A O 1 ATOM 4501 C CB . VAL A 1 593 ? -19.628 -1.323 -9.656 1.00 57.74 ? 594 VAL A CB 1 ATOM 4502 C CG1 . VAL A 1 593 ? -20.482 -0.259 -9.004 1.00 58.67 ? 594 VAL A CG1 1 ATOM 4503 C CG2 . VAL A 1 593 ? -20.222 -2.704 -9.378 1.00 65.34 ? 594 VAL A CG2 1 ATOM 4504 N N . GLU A 1 594 ? -17.100 -1.314 -11.508 1.00 67.07 ? 595 GLU A N 1 ATOM 4505 C CA . GLU A 1 594 ? -15.683 -0.911 -11.754 1.00 67.87 ? 595 GLU A CA 1 ATOM 4506 C C . GLU A 1 594 ? -15.398 -0.299 -13.129 1.00 66.12 ? 595 GLU A C 1 ATOM 4507 O O . GLU A 1 594 ? -14.285 0.162 -13.382 1.00 62.91 ? 595 GLU A O 1 ATOM 4508 C CB . GLU A 1 594 ? -14.711 -2.064 -11.499 1.00 68.73 ? 595 GLU A CB 1 ATOM 4509 C CG . GLU A 1 594 ? -14.433 -2.348 -10.030 1.00 83.78 ? 595 GLU A CG 1 ATOM 4510 C CD . GLU A 1 594 ? -13.988 -1.126 -9.244 1.00 90.94 ? 595 GLU A CD 1 ATOM 4511 O OE1 . GLU A 1 594 ? -13.026 -0.451 -9.674 1.00 110.50 ? 595 GLU A OE1 1 ATOM 4512 O OE2 . GLU A 1 594 ? -14.601 -0.844 -8.189 1.00 91.48 ? 595 GLU A OE2 1 ATOM 4513 N N . TYR A 1 595 ? -16.411 -0.291 -13.994 1.00 64.87 ? 596 TYR A N 1 ATOM 4514 C CA . TYR A 1 595 ? -16.307 0.264 -15.333 1.00 67.39 ? 596 TYR A CA 1 ATOM 4515 C C . TYR A 1 595 ? -17.299 1.422 -15.538 1.00 67.10 ? 596 TYR A C 1 ATOM 4516 O O . TYR A 1 595 ? -17.727 1.685 -16.670 1.00 64.51 ? 596 TYR A O 1 ATOM 4517 C CB . TYR A 1 595 ? -16.542 -0.845 -16.385 1.00 64.61 ? 596 TYR A CB 1 ATOM 4518 C CG . TYR A 1 595 ? -15.546 -1.983 -16.343 1.00 64.93 ? 596 TYR A CG 1 ATOM 4519 C CD1 . TYR A 1 595 ? -14.305 -1.899 -17.011 1.00 65.83 ? 596 TYR A CD1 1 ATOM 4520 C CD2 . TYR A 1 595 ? -15.833 -3.153 -15.646 1.00 65.95 ? 596 TYR A CD2 1 ATOM 4521 C CE1 . TYR A 1 595 ? -13.377 -2.946 -16.972 1.00 61.95 ? 596 TYR A CE1 1 ATOM 4522 C CE2 . TYR A 1 595 ? -14.906 -4.197 -15.592 1.00 73.55 ? 596 TYR A CE2 1 ATOM 4523 C CZ . TYR A 1 595 ? -13.682 -4.096 -16.261 1.00 68.96 ? 596 TYR A CZ 1 ATOM 4524 O OH . TYR A 1 595 ? -12.790 -5.153 -16.202 1.00 71.30 ? 596 TYR A OH 1 ATOM 4525 N N . VAL A 1 596 ? -17.667 2.121 -14.465 1.00 64.12 ? 597 VAL A N 1 ATOM 4526 C CA . VAL A 1 596 ? -18.727 3.145 -14.602 1.00 68.32 ? 597 VAL A CA 1 ATOM 4527 C C . VAL A 1 596 ? -18.212 4.471 -15.178 1.00 71.94 ? 597 VAL A C 1 ATOM 4528 O O . VAL A 1 596 ? -18.846 5.036 -16.082 1.00 64.14 ? 597 VAL A O 1 ATOM 4529 C CB . VAL A 1 596 ? -19.658 3.279 -13.351 1.00 60.44 ? 597 VAL A CB 1 ATOM 4530 C CG1 . VAL A 1 596 ? -20.231 4.676 -13.210 1.00 52.46 ? 597 VAL A CG1 1 ATOM 4531 C CG2 . VAL A 1 596 ? -20.802 2.286 -13.454 1.00 55.25 ? 597 VAL A CG2 1 ATOM 4532 N N . ASP A 1 597 ? -17.063 4.941 -14.685 1.00 79.99 ? 598 ASP A N 1 ATOM 4533 C CA . ASP A 1 597 ? -16.407 6.101 -15.286 1.00 82.75 ? 598 ASP A CA 1 ATOM 4534 C C . ASP A 1 597 ? -16.308 5.861 -16.792 1.00 77.52 ? 598 ASP A C 1 ATOM 4535 O O . ASP A 1 597 ? -16.792 6.673 -17.600 1.00 69.41 ? 598 ASP A O 1 ATOM 4536 C CB . ASP A 1 597 ? -15.027 6.329 -14.672 1.00 91.26 ? 598 ASP A CB 1 ATOM 4537 C CG . ASP A 1 597 ? -15.043 7.371 -13.571 1.00 106.47 ? 598 ASP A CG 1 ATOM 4538 O OD1 . ASP A 1 597 ? -15.244 8.570 -13.883 1.00 117.70 ? 598 ASP A OD1 1 ATOM 4539 O OD2 . ASP A 1 597 ? -14.832 6.994 -12.395 1.00 110.18 ? 598 ASP A OD2 1 ATOM 4540 N N . TRP A 1 598 ? -15.749 4.697 -17.137 1.00 71.20 ? 599 TRP A N 1 ATOM 4541 C CA . TRP A 1 598 ? -15.589 4.262 -18.517 1.00 68.41 ? 599 TRP A CA 1 ATOM 4542 C C . TRP A 1 598 ? -16.876 4.341 -19.382 1.00 66.90 ? 599 TRP A C 1 ATOM 4543 O O . TRP A 1 598 ? -16.858 4.926 -20.459 1.00 64.65 ? 599 TRP A O 1 ATOM 4544 C CB . TRP A 1 598 ? -14.979 2.857 -18.566 1.00 65.47 ? 599 TRP A CB 1 ATOM 4545 C CG . TRP A 1 598 ? -14.610 2.494 -19.961 1.00 67.27 ? 599 TRP A CG 1 ATOM 4546 C CD1 . TRP A 1 598 ? -13.550 2.970 -20.663 1.00 66.50 ? 599 TRP A CD1 1 ATOM 4547 C CD2 . TRP A 1 598 ? -15.327 1.626 -20.858 1.00 68.07 ? 599 TRP A CD2 1 ATOM 4548 N NE1 . TRP A 1 598 ? -13.546 2.448 -21.931 1.00 65.89 ? 599 TRP A NE1 1 ATOM 4549 C CE2 . TRP A 1 598 ? -14.625 1.620 -22.081 1.00 63.27 ? 599 TRP A CE2 1 ATOM 4550 C CE3 . TRP A 1 598 ? -16.490 0.848 -20.744 1.00 73.06 ? 599 TRP A CE3 1 ATOM 4551 C CZ2 . TRP A 1 598 ? -15.034 0.859 -23.184 1.00 63.06 ? 599 TRP A CZ2 1 ATOM 4552 C CZ3 . TRP A 1 598 ? -16.906 0.087 -21.860 1.00 74.10 ? 599 TRP A CZ3 1 ATOM 4553 C CH2 . TRP A 1 598 ? -16.175 0.105 -23.056 1.00 70.78 ? 599 TRP A CH2 1 ATOM 4554 N N . ILE A 1 599 ? -17.972 3.746 -18.913 1.00 64.70 ? 600 ILE A N 1 ATOM 4555 C CA . ILE A 1 599 ? -19.219 3.701 -19.682 1.00 63.48 ? 600 ILE A CA 1 ATOM 4556 C C . ILE A 1 599 ? -19.717 5.118 -19.894 1.00 68.43 ? 600 ILE A C 1 ATOM 4557 O O . ILE A 1 599 ? -20.211 5.448 -20.979 1.00 69.87 ? 600 ILE A O 1 ATOM 4558 C CB . ILE A 1 599 ? -20.311 2.830 -18.997 1.00 59.85 ? 600 ILE A CB 1 ATOM 4559 C CG1 . ILE A 1 599 ? -19.825 1.393 -18.861 1.00 55.19 ? 600 ILE A CG1 1 ATOM 4560 C CG2 . ILE A 1 599 ? -21.619 2.817 -19.792 1.00 53.80 ? 600 ILE A CG2 1 ATOM 4561 C CD1 . ILE A 1 599 ? -20.696 0.513 -18.002 1.00 56.87 ? 600 ILE A CD1 1 ATOM 4562 N N . LEU A 1 600 ? -19.542 5.947 -18.862 1.00 73.40 ? 601 LEU A N 1 ATOM 4563 C CA . LEU A 1 600 ? -20.055 7.324 -18.849 1.00 74.03 ? 601 LEU A CA 1 ATOM 4564 C C . LEU A 1 600 ? -19.227 8.222 -19.751 1.00 80.38 ? 601 LEU A C 1 ATOM 4565 O O . LEU A 1 600 ? -19.782 8.970 -20.558 1.00 80.92 ? 601 LEU A O 1 ATOM 4566 C CB . LEU A 1 600 ? -20.154 7.876 -17.413 1.00 64.33 ? 601 LEU A CB 1 ATOM 4567 C CG . LEU A 1 600 ? -21.238 7.300 -16.464 1.00 59.00 ? 601 LEU A CG 1 ATOM 4568 C CD1 . LEU A 1 600 ? -21.111 7.891 -15.072 1.00 57.55 ? 601 LEU A CD1 1 ATOM 4569 C CD2 . LEU A 1 600 ? -22.686 7.428 -16.944 1.00 52.47 ? 601 LEU A CD2 1 ATOM 4570 N N . GLU A 1 601 ? -17.906 8.125 -19.603 1.00 83.66 ? 602 GLU A N 1 ATOM 4571 C CA . GLU A 1 601 ? -16.957 8.595 -20.607 1.00 89.88 ? 602 GLU A CA 1 ATOM 4572 C C . GLU A 1 601 ? -17.491 8.310 -22.039 1.00 88.70 ? 602 GLU A C 1 ATOM 4573 O O . GLU A 1 601 ? -17.873 9.245 -22.747 1.00 96.59 ? 602 GLU A O 1 ATOM 4574 C CB . GLU A 1 601 ? -15.582 7.954 -20.334 1.00 96.76 ? 602 GLU A CB 1 ATOM 4575 C CG . GLU A 1 601 ? -14.433 8.305 -21.275 1.00 100.26 ? 602 GLU A CG 1 ATOM 4576 C CD . GLU A 1 601 ? -13.232 7.352 -21.165 1.00 102.83 ? 602 GLU A CD 1 ATOM 4577 O OE1 . GLU A 1 601 ? -13.039 6.669 -20.123 1.00 94.05 ? 602 GLU A OE1 1 ATOM 4578 O OE2 . GLU A 1 601 ? -12.458 7.295 -22.147 1.00 105.94 ? 602 GLU A OE2 1 ATOM 4579 N N . LYS A 1 602 ? -17.604 7.039 -22.426 1.00 82.14 ? 603 LYS A N 1 ATOM 4580 C CA . LYS A 1 602 ? -17.842 6.697 -23.828 1.00 77.85 ? 603 LYS A CA 1 ATOM 4581 C C . LYS A 1 602 ? -19.254 6.982 -24.332 1.00 85.36 ? 603 LYS A C 1 ATOM 4582 O O . LYS A 1 602 ? -19.552 6.696 -25.490 1.00 96.78 ? 603 LYS A O 1 ATOM 4583 C CB . LYS A 1 602 ? -17.363 5.271 -24.164 1.00 77.49 ? 603 LYS A CB 1 ATOM 4584 C CG . LYS A 1 602 ? -15.845 5.113 -24.406 1.00 88.16 ? 603 LYS A CG 1 ATOM 4585 C CD . LYS A 1 602 ? -15.331 5.910 -25.623 1.00 103.64 ? 603 LYS A CD 1 ATOM 4586 C CE . LYS A 1 602 ? -14.086 5.325 -26.294 1.00 106.14 ? 603 LYS A CE 1 ATOM 4587 N NZ . LYS A 1 602 ? -12.834 5.484 -25.506 1.00 104.64 ? 603 LYS A NZ 1 ATOM 4588 N N . THR A 1 603 ? -20.106 7.570 -23.485 1.00 89.30 ? 604 THR A N 1 ATOM 4589 C CA . THR A 1 603 ? -21.531 7.816 -23.821 1.00 88.95 ? 604 THR A CA 1 ATOM 4590 C C . THR A 1 603 ? -21.998 9.239 -23.512 1.00 96.09 ? 604 THR A C 1 ATOM 4591 O O . THR A 1 603 ? -22.958 9.704 -24.123 1.00 96.92 ? 604 THR A O 1 ATOM 4592 C CB . THR A 1 603 ? -22.482 6.879 -23.042 1.00 81.80 ? 604 THR A CB 1 ATOM 4593 O OG1 . THR A 1 603 ? -22.039 6.792 -21.684 1.00 81.01 ? 604 THR A OG1 1 ATOM 4594 C CG2 . THR A 1 603 ? -22.503 5.502 -23.615 1.00 77.61 ? 604 THR A CG2 1 ATOM 4595 N N . GLN A 1 604 ? -21.326 9.887 -22.548 1.00 105.89 ? 605 GLN A N 1 ATOM 4596 C CA . GLN A 1 604 ? -21.616 11.244 -21.987 1.00 107.50 ? 605 GLN A CA 1 ATOM 4597 C C . GLN A 1 604 ? -22.121 11.213 -20.541 1.00 106.45 ? 605 GLN A C 1 ATOM 4598 O O . GLN A 1 604 ? -23.004 10.425 -20.196 1.00 99.36 ? 605 GLN A O 1 ATOM 4599 C CB . GLN A 1 604 ? -22.523 12.118 -22.887 1.00 109.20 ? 605 GLN A CB 1 ATOM 4600 C CG . GLN A 1 604 ? -21.810 12.897 -23.994 1.00 110.61 ? 605 GLN A CG 1 ATOM 4601 C CD . GLN A 1 604 ? -20.486 12.268 -24.425 1.00 117.83 ? 605 GLN A CD 1 ATOM 4602 O OE1 . GLN A 1 604 ? -19.433 12.530 -23.822 1.00 112.23 ? 605 GLN A OE1 1 ATOM 4603 N NE2 . GLN A 1 604 ? -20.534 11.425 -25.461 1.00 101.02 ? 605 GLN A NE2 1 ATOM 4604 N N . GLU B 2 1 ? -15.129 28.688 8.489 1.00 103.89 ? 0 GLU B N 1 ATOM 4605 C CA . GLU B 2 1 ? -14.893 29.416 7.201 1.00 108.31 ? 0 GLU B CA 1 ATOM 4606 C C . GLU B 2 1 ? -13.391 29.640 6.883 1.00 106.27 ? 0 GLU B C 1 ATOM 4607 O O . GLU B 2 1 ? -12.567 29.757 7.791 1.00 107.95 ? 0 GLU B O 1 ATOM 4608 C CB . GLU B 2 1 ? -15.738 30.715 7.151 1.00 102.82 ? 0 GLU B CB 1 ATOM 4609 C CG . GLU B 2 1 ? -15.430 31.676 5.994 1.00 110.20 ? 0 GLU B CG 1 ATOM 4610 C CD . GLU B 2 1 ? -16.636 32.099 5.155 1.00 108.70 ? 0 GLU B CD 1 ATOM 4611 O OE1 . GLU B 2 1 ? -16.697 33.283 4.756 1.00 102.40 ? 0 GLU B OE1 1 ATOM 4612 O OE2 . GLU B 2 1 ? -17.510 31.256 4.860 1.00 110.52 ? 0 GLU B OE2 1 ATOM 4613 N N . PHE B 2 2 ? -13.058 29.635 5.586 1.00 105.90 ? 1 PHE B N 1 ATOM 4614 C CA . PHE B 2 2 ? -11.795 30.167 5.041 1.00 104.41 ? 1 PHE B CA 1 ATOM 4615 C C . PHE B 2 2 ? -12.075 31.513 4.377 1.00 105.22 ? 1 PHE B C 1 ATOM 4616 O O . PHE B 2 2 ? -13.150 31.687 3.793 1.00 96.06 ? 1 PHE B O 1 ATOM 4617 C CB . PHE B 2 2 ? -11.197 29.229 3.976 1.00 103.15 ? 1 PHE B CB 1 ATOM 4618 C CG . PHE B 2 2 ? -10.393 28.095 4.540 1.00 106.52 ? 1 PHE B CG 1 ATOM 4619 C CD1 . PHE B 2 2 ? -9.045 28.279 4.889 1.00 110.77 ? 1 PHE B CD1 1 ATOM 4620 C CD2 . PHE B 2 2 ? -10.974 26.837 4.724 1.00 102.41 ? 1 PHE B CD2 1 ATOM 4621 C CE1 . PHE B 2 2 ? -8.299 27.228 5.419 1.00 109.63 ? 1 PHE B CE1 1 ATOM 4622 C CE2 . PHE B 2 2 ? -10.232 25.783 5.255 1.00 102.05 ? 1 PHE B CE2 1 ATOM 4623 C CZ . PHE B 2 2 ? -8.895 25.978 5.601 1.00 107.46 ? 1 PHE B CZ 1 ATOM 4624 N N . PRO B 2 3 ? -11.118 32.475 4.448 1.00 114.09 ? 2 PRO B N 1 ATOM 4625 C CA . PRO B 2 3 ? -11.273 33.664 3.583 1.00 109.95 ? 2 PRO B CA 1 ATOM 4626 C C . PRO B 2 3 ? -11.227 33.245 2.103 1.00 106.78 ? 2 PRO B C 1 ATOM 4627 O O . PRO B 2 3 ? -10.529 32.280 1.766 1.00 114.29 ? 2 PRO B O 1 ATOM 4628 C CB . PRO B 2 3 ? -10.061 34.531 3.949 1.00 99.92 ? 2 PRO B CB 1 ATOM 4629 C CG . PRO B 2 3 ? -9.081 33.597 4.582 1.00 100.78 ? 2 PRO B CG 1 ATOM 4630 C CD . PRO B 2 3 ? -9.913 32.573 5.297 1.00 106.23 ? 2 PRO B CD 1 ATOM 4631 N N . ASP B 2 4 ? -11.987 33.916 1.241 1.00 92.36 ? 3 ASP B N 1 ATOM 4632 C CA . ASP B 2 4 ? -11.953 33.567 -0.176 1.00 92.39 ? 3 ASP B CA 1 ATOM 4633 C C . ASP B 2 4 ? -11.029 34.481 -0.955 1.00 89.37 ? 3 ASP B C 1 ATOM 4634 O O . ASP B 2 4 ? -10.378 35.341 -0.366 1.00 100.65 ? 3 ASP B O 1 ATOM 4635 C CB . ASP B 2 4 ? -13.361 33.405 -0.803 1.00 112.26 ? 3 ASP B CB 1 ATOM 4636 C CG . ASP B 2 4 ? -14.186 34.687 -0.800 1.00 111.63 ? 3 ASP B CG 1 ATOM 4637 O OD1 . ASP B 2 4 ? -14.130 35.460 0.175 1.00 116.25 ? 3 ASP B OD1 1 ATOM 4638 O OD2 . ASP B 2 4 ? -14.931 34.897 -1.775 1.00 112.37 ? 3 ASP B OD2 1 ATOM 4639 N N . PHE B 2 5 ? -10.965 34.276 -2.268 1.00 89.46 ? 4 PHE B N 1 ATOM 4640 C CA . PHE B 2 5 ? -9.972 34.894 -3.138 1.00 91.29 ? 4 PHE B CA 1 ATOM 4641 C C . PHE B 2 5 ? -10.028 36.434 -3.224 1.00 108.20 ? 4 PHE B C 1 ATOM 4642 O O . PHE B 2 5 ? -11.129 37.009 -3.217 1.00 111.87 ? 4 PHE B O 1 ATOM 4643 C CB . PHE B 2 5 ? -10.097 34.305 -4.539 1.00 84.14 ? 4 PHE B CB 1 ATOM 4644 C CG . PHE B 2 5 ? -9.782 32.843 -4.618 1.00 80.83 ? 4 PHE B CG 1 ATOM 4645 C CD1 . PHE B 2 5 ? -8.563 32.341 -4.162 1.00 82.02 ? 4 PHE B CD1 1 ATOM 4646 C CD2 . PHE B 2 5 ? -10.696 31.958 -5.182 1.00 89.74 ? 4 PHE B CD2 1 ATOM 4647 C CE1 . PHE B 2 5 ? -8.265 30.981 -4.254 1.00 84.40 ? 4 PHE B CE1 1 ATOM 4648 C CE2 . PHE B 2 5 ? -10.403 30.595 -5.290 1.00 91.78 ? 4 PHE B CE2 1 ATOM 4649 C CZ . PHE B 2 5 ? -9.188 30.104 -4.814 1.00 89.41 ? 4 PHE B CZ 1 ATOM 4650 N N . PRO B 2 6 ? -8.841 37.100 -3.298 1.00 108.12 ? 5 PRO B N 1 ATOM 4651 C CA . PRO B 2 6 ? -8.755 38.541 -3.559 1.00 99.12 ? 5 PRO B CA 1 ATOM 4652 C C . PRO B 2 6 ? -9.012 38.868 -5.025 1.00 91.27 ? 5 PRO B C 1 ATOM 4653 O O . PRO B 2 6 ? -9.041 40.042 -5.379 1.00 93.30 ? 5 PRO B O 1 ATOM 4654 C CB . PRO B 2 6 ? -7.305 38.870 -3.203 1.00 103.65 ? 5 PRO B CB 1 ATOM 4655 C CG . PRO B 2 6 ? -6.556 37.607 -3.463 1.00 97.66 ? 5 PRO B CG 1 ATOM 4656 C CD . PRO B 2 6 ? -7.504 36.526 -3.025 1.00 100.94 ? 5 PRO B CD 1 HETATM 4657 C C1 . NAG C 3 . ? -39.847 43.692 -29.339 1.00 118.20 ? 901 NAG A C1 1 HETATM 4658 C C2 . NAG C 3 . ? -39.695 42.409 -30.204 1.00 125.66 ? 901 NAG A C2 1 HETATM 4659 C C3 . NAG C 3 . ? -40.762 42.219 -31.310 1.00 130.29 ? 901 NAG A C3 1 HETATM 4660 C C4 . NAG C 3 . ? -41.262 43.459 -32.074 1.00 124.96 ? 901 NAG A C4 1 HETATM 4661 C C5 . NAG C 3 . ? -41.071 44.799 -31.340 1.00 117.88 ? 901 NAG A C5 1 HETATM 4662 C C6 . NAG C 3 . ? -42.443 45.401 -31.021 1.00 110.37 ? 901 NAG A C6 1 HETATM 4663 C C7 . NAG C 3 . ? -37.626 42.774 -31.685 1.00 126.15 ? 901 NAG A C7 1 HETATM 4664 C C8 . NAG C 3 . ? -36.304 42.136 -32.010 1.00 121.16 ? 901 NAG A C8 1 HETATM 4665 N N2 . NAG C 3 . ? -38.358 42.117 -30.759 1.00 129.31 ? 901 NAG A N2 1 HETATM 4666 O O3 . NAG C 3 . ? -41.914 41.627 -30.717 1.00 146.72 ? 901 NAG A O3 1 HETATM 4667 O O4 . NAG C 3 . ? -40.717 43.509 -33.407 1.00 114.03 ? 901 NAG A O4 1 HETATM 4668 O O5 . NAG C 3 . ? -40.193 44.830 -30.172 1.00 118.25 ? 901 NAG A O5 1 HETATM 4669 O O6 . NAG C 3 . ? -42.874 44.989 -29.720 1.00 96.43 ? 901 NAG A O6 1 HETATM 4670 O O7 . NAG C 3 . ? -37.958 43.812 -32.240 1.00 122.47 ? 901 NAG A O7 1 HETATM 4671 C C1 . NAG D 3 . ? -9.333 18.616 2.301 1.00 80.13 ? 902 NAG A C1 1 HETATM 4672 C C2 . NAG D 3 . ? -8.945 17.174 1.781 1.00 82.22 ? 902 NAG A C2 1 HETATM 4673 C C3 . NAG D 3 . ? -7.946 16.368 2.683 1.00 92.09 ? 902 NAG A C3 1 HETATM 4674 C C4 . NAG D 3 . ? -7.537 16.958 4.052 1.00 92.99 ? 902 NAG A C4 1 HETATM 4675 C C5 . NAG D 3 . ? -8.598 17.954 4.549 1.00 87.43 ? 902 NAG A C5 1 HETATM 4676 C C6 . NAG D 3 . ? -8.316 18.587 5.917 1.00 78.49 ? 902 NAG A C6 1 HETATM 4677 C C7 . NAG D 3 . ? -10.648 15.142 1.336 1.00 82.07 ? 902 NAG A C7 1 HETATM 4678 C C8 . NAG D 3 . ? -9.776 13.947 1.009 1.00 66.92 ? 902 NAG A C8 1 HETATM 4679 N N2 . NAG D 3 . ? -10.202 16.405 1.608 1.00 85.48 ? 902 NAG A N2 1 HETATM 4680 O O3 . NAG D 3 . ? -6.730 15.984 2.003 1.00 99.30 ? 902 NAG A O3 1 HETATM 4681 O O4 . NAG D 3 . ? -7.263 15.894 4.984 1.00 96.15 ? 902 NAG A O4 1 HETATM 4682 O O5 . NAG D 3 . ? -8.655 18.961 3.528 1.00 82.40 ? 902 NAG A O5 1 HETATM 4683 O O6 . NAG D 3 . ? -9.091 19.788 6.037 1.00 74.78 ? 902 NAG A O6 1 HETATM 4684 O O7 . NAG D 3 . ? -11.863 14.976 1.354 1.00 84.60 ? 902 NAG A O7 1 HETATM 4685 C C1 . NAG E 3 . ? -42.349 -20.561 -29.679 1.00 128.38 ? 903 NAG A C1 1 HETATM 4686 C C2 . NAG E 3 . ? -42.571 -22.111 -29.694 1.00 134.43 ? 903 NAG A C2 1 HETATM 4687 C C3 . NAG E 3 . ? -43.899 -22.528 -29.038 1.00 131.01 ? 903 NAG A C3 1 HETATM 4688 C C4 . NAG E 3 . ? -44.241 -21.651 -27.837 1.00 120.58 ? 903 NAG A C4 1 HETATM 4689 C C5 . NAG E 3 . ? -44.449 -20.212 -28.332 1.00 117.06 ? 903 NAG A C5 1 HETATM 4690 C C6 . NAG E 3 . ? -44.257 -19.230 -27.183 1.00 113.27 ? 903 NAG A C6 1 HETATM 4691 C C7 . NAG E 3 . ? -42.048 -23.877 -31.459 1.00 123.66 ? 903 NAG A C7 1 HETATM 4692 C C8 . NAG E 3 . ? -41.191 -24.717 -30.539 1.00 111.39 ? 903 NAG A C8 1 HETATM 4693 N N2 . NAG E 3 . ? -42.611 -22.727 -31.024 1.00 132.22 ? 903 NAG A N2 1 HETATM 4694 O O3 . NAG E 3 . ? -43.896 -23.922 -28.692 1.00 137.58 ? 903 NAG A O3 1 HETATM 4695 O O4 . NAG E 3 . ? -45.402 -22.157 -27.177 1.00 114.68 ? 903 NAG A O4 1 HETATM 4696 O O5 . NAG E 3 . ? -43.601 -19.856 -29.467 1.00 119.69 ? 903 NAG A O5 1 HETATM 4697 O O6 . NAG E 3 . ? -44.637 -17.926 -27.631 1.00 100.79 ? 903 NAG A O6 1 HETATM 4698 O O7 . NAG E 3 . ? -42.221 -24.225 -32.618 1.00 116.61 ? 903 NAG A O7 1 # loop_ _database_PDB_caveat.id _database_PDB_caveat.text 1 'LYS A 8 HAS WRONG CHIRALITY AT ATOM CA' 2 'NAG A 901 HAS WRONG CHIRALITY AT ATOM C1' 3 'NAG A 902 HAS WRONG CHIRALITY AT ATOM C1' # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 CYS 1 2 2 CYS CYS A . n A 1 2 VAL 2 3 3 VAL VAL A . n A 1 3 THR 3 4 4 THR THR A . n A 1 4 GLN 4 5 5 GLN GLN A . n A 1 5 LEU 5 6 6 LEU LEU A . n A 1 6 LEU 6 7 7 LEU LEU A . n A 1 7 LYS 7 8 8 LYS LYS A . n A 1 8 ASP 8 9 9 ASP ASP A . n A 1 9 THR 9 10 10 THR THR A . n A 1 10 CYS 10 11 11 CYS CYS A . n A 1 11 PHE 11 12 12 PHE PHE A . n A 1 12 GLU 12 13 13 GLU GLU A . n A 1 13 GLY 13 14 14 GLY GLY A . n A 1 14 GLY 14 15 15 GLY GLY A . n A 1 15 ASP 15 16 16 ASP ASP A . n A 1 16 ILE 16 17 17 ILE ILE A . n A 1 17 THR 17 18 18 THR THR A . n A 1 18 THR 18 19 19 THR THR A . n A 1 19 VAL 19 20 20 VAL VAL A . n A 1 20 PHE 20 21 21 PHE PHE A . n A 1 21 THR 21 22 22 THR THR A . n A 1 22 PRO 22 23 23 PRO PRO A . n A 1 23 SER 23 24 24 SER SER A . n A 1 24 ALA 24 25 25 ALA ALA A . n A 1 25 LYS 25 26 26 LYS LYS A . n A 1 26 TYR 26 27 27 TYR TYR A . n A 1 27 CYS 27 28 28 CYS CYS A . n A 1 28 GLN 28 29 29 GLN GLN A . n A 1 29 VAL 29 30 30 VAL VAL A . n A 1 30 VAL 30 31 31 VAL VAL A . n A 1 31 CYS 31 32 32 CYS CYS A . n A 1 32 THR 32 33 33 THR THR A . n A 1 33 TYR 33 34 34 TYR TYR A . n A 1 34 HIS 34 35 35 HIS HIS A . n A 1 35 PRO 35 36 36 PRO PRO A . n A 1 36 ARG 36 37 37 ARG ARG A . n A 1 37 CYS 37 38 38 CYS CYS A . n A 1 38 LEU 38 39 39 LEU LEU A . n A 1 39 LEU 39 40 40 LEU LEU A . n A 1 40 PHE 40 41 41 PHE PHE A . n A 1 41 THR 41 42 42 THR THR A . n A 1 42 PHE 42 43 43 PHE PHE A . n A 1 43 THR 43 44 44 THR THR A . n A 1 44 ALA 44 45 45 ALA ALA A . n A 1 45 GLU 45 46 46 GLU GLU A . n A 1 46 SER 46 47 47 SER SER A . n A 1 47 PRO 47 48 48 PRO PRO A . n A 1 48 SER 48 49 49 SER SER A . n A 1 49 GLU 49 50 50 GLU GLU A . n A 1 50 ASP 50 51 51 ASP ASP A . n A 1 51 PRO 51 52 52 PRO PRO A . n A 1 52 THR 52 53 53 THR THR A . n A 1 53 ARG 53 54 54 ARG ARG A . n A 1 54 TRP 54 55 55 TRP TRP A . n A 1 55 PHE 55 56 56 PHE PHE A . n A 1 56 THR 56 57 57 THR THR A . n A 1 57 CYS 57 58 58 CYS CYS A . n A 1 58 VAL 58 59 59 VAL VAL A . n A 1 59 LEU 59 60 60 LEU LEU A . n A 1 60 LYS 60 61 61 LYS LYS A . n A 1 61 ASP 61 62 62 ASP ASP A . n A 1 62 SER 62 63 63 SER SER A . n A 1 63 VAL 63 64 64 VAL VAL A . n A 1 64 THR 64 65 65 THR THR A . n A 1 65 GLU 65 66 66 GLU GLU A . n A 1 66 THR 66 67 67 THR THR A . n A 1 67 LEU 67 68 68 LEU LEU A . n A 1 68 PRO 68 69 69 PRO PRO A . n A 1 69 ARG 69 70 70 ARG ARG A . n A 1 70 VAL 70 71 71 VAL VAL A . n A 1 71 ASN 71 72 72 ASN ASN A . n A 1 72 ARG 72 73 73 ARG ARG A . n A 1 73 THR 73 74 74 THR THR A . n A 1 74 ALA 74 75 75 ALA ALA A . n A 1 75 ALA 75 76 76 ALA ALA A . n A 1 76 ILE 76 77 77 ILE ILE A . n A 1 77 SER 77 78 78 SER SER A . n A 1 78 GLY 78 79 79 GLY GLY A . n A 1 79 TYR 79 80 80 TYR TYR A . n A 1 80 SER 80 81 81 SER SER A . n A 1 81 PHE 81 82 82 PHE PHE A . n A 1 82 LYS 82 83 83 LYS LYS A . n A 1 83 GLN 83 84 84 GLN GLN A . n A 1 84 CYS 84 85 85 CYS CYS A . n A 1 85 SER 85 86 86 SER SER A . n A 1 86 HIS 86 87 87 HIS HIS A . n A 1 87 GLN 87 88 88 GLN GLN A . n A 1 88 ILE 88 89 89 ILE ILE A . n A 1 89 SER 89 90 90 SER SER A . n A 1 90 ALA 90 91 91 ALA ALA A . n A 1 91 CYS 91 92 92 CYS CYS A . n A 1 92 ASN 92 93 93 ASN ASN A . n A 1 93 LYS 93 94 94 LYS LYS A . n A 1 94 ASP 94 95 95 ASP ASP A . n A 1 95 ILE 95 96 96 ILE ILE A . n A 1 96 TYR 96 97 97 TYR TYR A . n A 1 97 VAL 97 98 98 VAL VAL A . n A 1 98 ASP 98 99 99 ASP ASP A . n A 1 99 LEU 99 100 100 LEU LEU A . n A 1 100 ASP 100 101 101 ASP ASP A . n A 1 101 MET 101 102 102 MET MET A . n A 1 102 LYS 102 103 103 LYS LYS A . n A 1 103 GLY 103 104 104 GLY GLY A . n A 1 104 ILE 104 105 105 ILE ILE A . n A 1 105 ASN 105 106 106 ASN ASN A . n A 1 106 TYR 106 107 107 TYR TYR A . n A 1 107 ASN 107 108 108 ASN ASN A . n A 1 108 SER 108 109 109 SER SER A . n A 1 109 SER 109 110 110 SER SER A . n A 1 110 VAL 110 111 111 VAL VAL A . n A 1 111 ALA 111 112 112 ALA ALA A . n A 1 112 LYS 112 113 113 LYS LYS A . n A 1 113 SER 113 114 114 SER SER A . n A 1 114 ALA 114 115 115 ALA ALA A . n A 1 115 GLN 115 116 116 GLN GLN A . n A 1 116 GLU 116 117 117 GLU GLU A . n A 1 117 CYS 117 118 118 CYS CYS A . n A 1 118 GLN 118 119 119 GLN GLN A . n A 1 119 GLU 119 120 120 GLU GLU A . n A 1 120 ARG 120 121 121 ARG ARG A . n A 1 121 CYS 121 122 122 CYS CYS A . n A 1 122 THR 122 123 123 THR THR A . n A 1 123 ASP 123 124 124 ASP ASP A . n A 1 124 ASP 124 125 125 ASP ASP A . n A 1 125 VAL 125 126 126 VAL VAL A . n A 1 126 HIS 126 127 127 HIS HIS A . n A 1 127 CYS 127 128 128 CYS CYS A . n A 1 128 HIS 128 129 129 HIS HIS A . n A 1 129 PHE 129 130 130 PHE PHE A . n A 1 130 PHE 130 131 131 PHE PHE A . n A 1 131 THR 131 132 132 THR THR A . n A 1 132 TYR 132 133 133 TYR TYR A . n A 1 133 ALA 133 134 134 ALA ALA A . n A 1 134 THR 134 135 135 THR THR A . n A 1 135 ARG 135 136 136 ARG ARG A . n A 1 136 GLN 136 137 137 GLN GLN A . n A 1 137 PHE 137 138 138 PHE PHE A . n A 1 138 PRO 138 139 139 PRO PRO A . n A 1 139 SER 139 140 140 SER SER A . n A 1 140 LEU 140 141 141 LEU LEU A . n A 1 141 GLU 141 142 142 GLU GLU A . n A 1 142 HIS 142 143 143 HIS HIS A . n A 1 143 ARG 143 144 144 ARG ARG A . n A 1 144 ASN 144 145 145 ASN ASN A . n A 1 145 ILE 145 146 146 ILE ILE A . n A 1 146 CYS 146 147 147 CYS CYS A . n A 1 147 LEU 147 148 148 LEU LEU A . n A 1 148 LEU 148 149 149 LEU LEU A . n A 1 149 LYS 149 150 150 LYS LYS A . n A 1 150 HIS 150 151 151 HIS HIS A . n A 1 151 THR 151 152 152 THR THR A . n A 1 152 GLN 152 153 153 GLN GLN A . n A 1 153 THR 153 154 154 THR THR A . n A 1 154 GLY 154 155 155 GLY GLY A . n A 1 155 THR 155 156 156 THR THR A . n A 1 156 PRO 156 157 157 PRO PRO A . n A 1 157 THR 157 158 158 THR THR A . n A 1 158 ARG 158 159 159 ARG ARG A . n A 1 159 ILE 159 160 160 ILE ILE A . n A 1 160 THR 160 161 161 THR THR A . n A 1 161 LYS 161 162 162 LYS LYS A . n A 1 162 LEU 162 163 163 LEU LEU A . n A 1 163 ASP 163 164 164 ASP ASP A . n A 1 164 LYS 164 165 165 LYS LYS A . n A 1 165 VAL 165 166 166 VAL VAL A . n A 1 166 VAL 166 167 167 VAL VAL A . n A 1 167 SER 167 168 168 SER SER A . n A 1 168 GLY 168 169 169 GLY GLY A . n A 1 169 PHE 169 170 170 PHE PHE A . n A 1 170 SER 170 171 171 SER SER A . n A 1 171 LEU 171 172 172 LEU LEU A . n A 1 172 LYS 172 173 173 LYS LYS A . n A 1 173 SER 173 174 174 SER SER A . n A 1 174 CYS 174 175 175 CYS CYS A . n A 1 175 ALA 175 176 176 ALA ALA A . n A 1 176 LEU 176 177 177 LEU LEU A . n A 1 177 SER 177 178 178 SER SER A . n A 1 178 ASN 178 179 179 ASN ASN A . n A 1 179 LEU 179 180 180 LEU LEU A . n A 1 180 ALA 180 181 181 ALA ALA A . n A 1 181 CYS 181 182 182 CYS CYS A . n A 1 182 ILE 182 183 183 ILE ILE A . n A 1 183 ARG 183 184 184 ARG ARG A . n A 1 184 ASP 184 185 185 ASP ASP A . n A 1 185 ILE 185 186 186 ILE ILE A . n A 1 186 PHE 186 187 187 PHE PHE A . n A 1 187 PRO 187 188 188 PRO PRO A . n A 1 188 ASN 188 189 189 ASN ASN A . n A 1 189 THR 189 190 190 THR THR A . n A 1 190 VAL 190 191 191 VAL VAL A . n A 1 191 PHE 191 192 192 PHE PHE A . n A 1 192 ALA 192 193 193 ALA ALA A . n A 1 193 ASP 193 194 194 ASP ASP A . n A 1 194 SER 194 195 195 SER SER A . n A 1 195 ASN 195 196 196 ASN ASN A . n A 1 196 ILE 196 197 197 ILE ILE A . n A 1 197 ASP 197 198 198 ASP ASP A . n A 1 198 SER 198 199 199 SER SER A . n A 1 199 VAL 199 200 200 VAL VAL A . n A 1 200 MET 200 201 201 MET MET A . n A 1 201 ALA 201 202 202 ALA ALA A . n A 1 202 PRO 202 203 203 PRO PRO A . n A 1 203 ASP 203 204 204 ASP ASP A . n A 1 204 ALA 204 205 205 ALA ALA A . n A 1 205 PHE 205 206 206 PHE PHE A . n A 1 206 VAL 206 207 207 VAL VAL A . n A 1 207 CYS 207 208 208 CYS CYS A . n A 1 208 GLY 208 209 209 GLY GLY A . n A 1 209 ARG 209 210 210 ARG ARG A . n A 1 210 ILE 210 211 211 ILE ILE A . n A 1 211 CYS 211 212 212 CYS CYS A . n A 1 212 THR 212 213 213 THR THR A . n A 1 213 HIS 213 214 214 HIS HIS A . n A 1 214 HIS 214 215 215 HIS HIS A . n A 1 215 PRO 215 216 216 PRO PRO A . n A 1 216 GLY 216 217 217 GLY GLY A . n A 1 217 CYS 217 218 218 CYS CYS A . n A 1 218 LEU 218 219 219 LEU LEU A . n A 1 219 PHE 219 220 220 PHE PHE A . n A 1 220 PHE 220 221 221 PHE PHE A . n A 1 221 THR 221 222 222 THR THR A . n A 1 222 PHE 222 223 223 PHE PHE A . n A 1 223 PHE 223 224 224 PHE PHE A . n A 1 224 SER 224 225 225 SER SER A . n A 1 225 GLN 225 226 226 GLN GLN A . n A 1 226 GLU 226 227 227 GLU GLU A . n A 1 227 TRP 227 228 228 TRP TRP A . n A 1 228 PRO 228 229 229 PRO PRO A . n A 1 229 LYS 229 230 230 LYS LYS A . n A 1 230 GLU 230 231 231 GLU GLU A . n A 1 231 SER 231 232 232 SER SER A . n A 1 232 GLN 232 233 233 GLN GLN A . n A 1 233 ARG 233 234 234 ARG ARG A . n A 1 234 ASN 234 235 235 ASN ASN A . n A 1 235 LEU 235 236 236 LEU LEU A . n A 1 236 CYS 236 237 237 CYS CYS A . n A 1 237 LEU 237 238 238 LEU LEU A . n A 1 238 LEU 238 239 239 LEU LEU A . n A 1 239 LYS 239 240 240 LYS LYS A . n A 1 240 THR 240 241 241 THR THR A . n A 1 241 SER 241 242 242 SER SER A . n A 1 242 GLU 242 243 243 GLU GLU A . n A 1 243 SER 243 244 244 SER SER A . n A 1 244 GLY 244 245 245 GLY GLY A . n A 1 245 LEU 245 246 246 LEU LEU A . n A 1 246 PRO 246 247 247 PRO PRO A . n A 1 247 SER 247 248 248 SER SER A . n A 1 248 THR 248 249 249 THR THR A . n A 1 249 ARG 249 250 250 ARG ARG A . n A 1 250 ILE 250 251 251 ILE ILE A . n A 1 251 LYS 251 252 252 LYS LYS A . n A 1 252 LYS 252 253 253 LYS LYS A . n A 1 253 SER 253 254 254 SER SER A . n A 1 254 LYS 254 255 255 LYS LYS A . n A 1 255 ALA 255 256 256 ALA ALA A . n A 1 256 LEU 256 257 257 LEU LEU A . n A 1 257 SER 257 258 258 SER SER A . n A 1 258 GLY 258 259 259 GLY GLY A . n A 1 259 PHE 259 260 260 PHE PHE A . n A 1 260 SER 260 261 261 SER SER A . n A 1 261 LEU 261 262 262 LEU LEU A . n A 1 262 GLN 262 263 263 GLN GLN A . n A 1 263 SER 263 264 264 SER SER A . n A 1 264 CYS 264 265 265 CYS CYS A . n A 1 265 ARG 265 266 266 ARG ARG A . n A 1 266 HIS 266 267 267 HIS HIS A . n A 1 267 SER 267 268 268 SER SER A . n A 1 268 ILE 268 269 269 ILE ILE A . n A 1 269 PRO 269 270 270 PRO PRO A . n A 1 270 VAL 270 271 271 VAL VAL A . n A 1 271 PHE 271 272 272 PHE PHE A . n A 1 272 CYS 272 273 273 CYS CYS A . n A 1 273 HIS 273 274 274 HIS HIS A . n A 1 274 SER 274 275 275 SER SER A . n A 1 275 SER 275 276 276 SER SER A . n A 1 276 PHE 276 277 277 PHE PHE A . n A 1 277 TYR 277 278 278 TYR TYR A . n A 1 278 HIS 278 279 279 HIS HIS A . n A 1 279 ASP 279 280 280 ASP ASP A . n A 1 280 THR 280 281 281 THR THR A . n A 1 281 ASP 281 282 282 ASP ASP A . n A 1 282 PHE 282 283 283 PHE PHE A . n A 1 283 LEU 283 284 284 LEU LEU A . n A 1 284 GLY 284 285 285 GLY GLY A . n A 1 285 GLU 285 286 286 GLU GLU A . n A 1 286 GLU 286 287 287 GLU GLU A . n A 1 287 LEU 287 288 288 LEU LEU A . n A 1 288 ASP 288 289 289 ASP ASP A . n A 1 289 ILE 289 290 290 ILE ILE A . n A 1 290 VAL 290 291 291 VAL VAL A . n A 1 291 ALA 291 292 292 ALA ALA A . n A 1 292 ALA 292 293 293 ALA ALA A . n A 1 293 LYS 293 294 294 LYS LYS A . n A 1 294 SER 294 295 295 SER SER A . n A 1 295 HIS 295 296 296 HIS HIS A . n A 1 296 GLU 296 297 297 GLU GLU A . n A 1 297 ALA 297 298 298 ALA ALA A . n A 1 298 CYS 298 299 299 CYS CYS A . n A 1 299 GLN 299 300 300 GLN GLN A . n A 1 300 LYS 300 301 301 LYS LYS A . n A 1 301 LEU 301 302 302 LEU LEU A . n A 1 302 CYS 302 303 303 CYS CYS A . n A 1 303 THR 303 304 304 THR THR A . n A 1 304 ASN 304 305 305 ASN ASN A . n A 1 305 ALA 305 306 306 ALA ALA A . n A 1 306 VAL 306 307 307 VAL VAL A . n A 1 307 ARG 307 308 308 ARG ARG A . n A 1 308 CYS 308 309 309 CYS CYS A . n A 1 309 GLN 309 310 310 GLN GLN A . n A 1 310 PHE 310 311 311 PHE PHE A . n A 1 311 PHE 311 312 312 PHE PHE A . n A 1 312 THR 312 313 313 THR THR A . n A 1 313 TYR 313 314 314 TYR TYR A . n A 1 314 THR 314 315 315 THR THR A . n A 1 315 PRO 315 316 316 PRO PRO A . n A 1 316 ALA 316 317 317 ALA ALA A . n A 1 317 GLN 317 318 318 GLN GLY A . n A 1 318 ALA 318 319 ? ? ? A . n A 1 319 SER 319 320 ? ? ? A . n A 1 320 CYS 320 321 ? ? ? A . n A 1 321 ASN 321 322 322 ASN ASN A . n A 1 322 GLU 322 323 323 GLU GLU A . n A 1 323 GLY 323 324 324 GLY GLY A . n A 1 324 LYS 324 325 325 LYS LYS A . n A 1 325 GLY 325 326 326 GLY GLY A . n A 1 326 LYS 326 327 327 LYS LYS A . n A 1 327 CYS 327 328 328 CYS CYS A . n A 1 328 TYR 328 329 329 TYR TYR A . n A 1 329 LEU 329 330 330 LEU LEU A . n A 1 330 LYS 330 331 331 LYS LYS A . n A 1 331 LEU 331 332 332 LEU LEU A . n A 1 332 SER 332 333 333 SER SER A . n A 1 333 SER 333 334 334 SER SER A . n A 1 334 ASN 334 335 335 ASN ASN A . n A 1 335 GLY 335 336 336 GLY GLY A . n A 1 336 SER 336 337 337 SER SER A . n A 1 337 PRO 337 338 338 PRO PRO A . n A 1 338 THR 338 339 339 THR THR A . n A 1 339 LYS 339 340 340 LYS LYS A . n A 1 340 ILE 340 341 341 ILE ILE A . n A 1 341 LEU 341 342 342 LEU LEU A . n A 1 342 HIS 342 343 343 HIS HIS A . n A 1 343 GLY 343 344 344 GLY GLY A . n A 1 344 ARG 344 345 345 ARG ARG A . n A 1 345 GLY 345 346 346 GLY GLY A . n A 1 346 GLY 346 347 347 GLY GLY A . n A 1 347 ILE 347 348 348 ILE ILE A . n A 1 348 SER 348 349 349 SER SER A . n A 1 349 GLY 349 350 350 GLY GLY A . n A 1 350 TYR 350 351 351 TYR TYR A . n A 1 351 THR 351 352 352 THR THR A . n A 1 352 LEU 352 353 353 LEU LEU A . n A 1 353 ARG 353 354 354 ARG ARG A . n A 1 354 LEU 354 355 355 LEU LEU A . n A 1 355 CYS 355 356 356 CYS CYS A . n A 1 356 LYS 356 357 357 LYS LYS A . n A 1 357 MET 357 358 358 MET MET A . n A 1 358 ASP 358 359 359 ASP ASP A . n A 1 359 ASN 359 360 360 ASN ASN A . n A 1 360 GLU 360 361 361 GLU GLU A . n A 1 361 CYS 361 362 362 CYS CYS A . n A 1 362 THR 362 363 363 THR THR A . n A 1 363 THR 363 364 364 THR THR A . n A 1 364 LYS 364 365 365 LYS LYS A . n A 1 365 ILE 365 366 366 ILE ILE A . n A 1 366 LYS 366 367 367 LYS LYS A . n A 1 367 PRO 367 368 368 PRO PRO A . n A 1 368 ARG 368 369 369 ARG ARG A . n A 1 369 ILE 369 370 370 ILE ILE A . n A 1 370 VAL 370 371 371 VAL VAL A . n A 1 371 GLY 371 372 372 GLY GLY A . n A 1 372 GLY 372 373 373 GLY GLY A . n A 1 373 THR 373 374 374 THR THR A . n A 1 374 ALA 374 375 375 ALA ALA A . n A 1 375 SER 375 376 376 SER SER A . n A 1 376 VAL 376 377 377 VAL VAL A . n A 1 377 ARG 377 378 378 ARG ARG A . n A 1 378 GLY 378 379 379 GLY GLY A . n A 1 379 GLU 379 380 380 GLU GLU A . n A 1 380 TRP 380 381 381 TRP TRP A . n A 1 381 PRO 381 382 382 PRO PRO A . n A 1 382 TRP 382 383 383 TRP TRP A . n A 1 383 GLN 383 384 384 GLN GLN A . n A 1 384 VAL 384 385 385 VAL VAL A . n A 1 385 THR 385 386 386 THR THR A . n A 1 386 LEU 386 387 387 LEU LEU A . n A 1 387 HIS 387 388 388 HIS HIS A . n A 1 388 THR 388 389 389 THR THR A . n A 1 389 THR 389 390 390 THR THR A . n A 1 390 SER 390 391 391 SER SER A . n A 1 391 PRO 391 392 392 PRO PRO A . n A 1 392 THR 392 393 393 THR THR A . n A 1 393 GLN 393 394 394 GLN GLN A . n A 1 394 ARG 394 395 395 ARG ARG A . n A 1 395 HIS 395 396 396 HIS HIS A . n A 1 396 LEU 396 397 397 LEU LEU A . n A 1 397 CYS 397 398 398 CYS CYS A . n A 1 398 GLY 398 399 399 GLY GLY A . n A 1 399 GLY 399 400 400 GLY GLY A . n A 1 400 SER 400 401 401 SER SER A . n A 1 401 ILE 401 402 402 ILE ILE A . n A 1 402 ILE 402 403 403 ILE ILE A . n A 1 403 GLY 403 404 404 GLY GLY A . n A 1 404 ASN 404 405 405 ASN ASN A . n A 1 405 GLN 405 406 406 GLN GLN A . n A 1 406 TRP 406 407 407 TRP TRP A . n A 1 407 ILE 407 408 408 ILE ILE A . n A 1 408 LEU 408 409 409 LEU LEU A . n A 1 409 THR 409 410 410 THR THR A . n A 1 410 ALA 410 411 411 ALA ALA A . n A 1 411 ALA 411 412 412 ALA ALA A . n A 1 412 HIS 412 413 413 HIS HIS A . n A 1 413 CYS 413 414 414 CYS CYS A . n A 1 414 PHE 414 415 415 PHE PHE A . n A 1 415 TYR 415 416 416 TYR TYR A . n A 1 416 GLY 416 417 417 GLY GLY A . n A 1 417 VAL 417 418 418 VAL VAL A . n A 1 418 GLU 418 419 419 GLU GLU A . n A 1 419 SER 419 420 420 SER SER A . n A 1 420 PRO 420 421 421 PRO PRO A . n A 1 421 LYS 421 422 422 LYS LYS A . n A 1 422 ILE 422 423 423 ILE ILE A . n A 1 423 LEU 423 424 424 LEU LEU A . n A 1 424 ARG 424 425 425 ARG ARG A . n A 1 425 VAL 425 426 426 VAL VAL A . n A 1 426 TYR 426 427 427 TYR TYR A . n A 1 427 SER 427 428 428 SER SER A . n A 1 428 GLY 428 429 429 GLY GLY A . n A 1 429 ILE 429 430 430 ILE ILE A . n A 1 430 LEU 430 431 431 LEU LEU A . n A 1 431 ASN 431 432 432 ASN ASN A . n A 1 432 GLN 432 433 433 GLN GLN A . n A 1 433 SER 433 434 434 SER SER A . n A 1 434 GLU 434 435 435 GLU GLU A . n A 1 435 ILE 435 436 436 ILE ILE A . n A 1 436 LYS 436 437 437 LYS LYS A . n A 1 437 GLU 437 438 438 GLU GLU A . n A 1 438 ASP 438 439 439 ASP ASP A . n A 1 439 THR 439 440 440 THR THR A . n A 1 440 SER 440 441 441 SER SER A . n A 1 441 PHE 441 442 442 PHE PHE A . n A 1 442 PHE 442 443 443 PHE PHE A . n A 1 443 GLY 443 444 444 GLY GLY A . n A 1 444 VAL 444 445 445 VAL VAL A . n A 1 445 GLN 445 446 446 GLN GLN A . n A 1 446 GLU 446 447 447 GLU GLU A . n A 1 447 ILE 447 448 448 ILE ILE A . n A 1 448 ILE 448 449 449 ILE ILE A . n A 1 449 ILE 449 450 450 ILE ILE A . n A 1 450 HIS 450 451 451 HIS HIS A . n A 1 451 ASP 451 452 452 ASP ASP A . n A 1 452 GLN 452 453 453 GLN GLN A . n A 1 453 TYR 453 454 454 TYR TYR A . n A 1 454 LYS 454 455 455 LYS LYS A . n A 1 455 MET 455 456 456 MET MET A . n A 1 456 ALA 456 457 457 ALA ALA A . n A 1 457 GLU 457 458 458 GLU GLU A . n A 1 458 SER 458 459 459 SER SER A . n A 1 459 GLY 459 460 460 GLY GLY A . n A 1 460 TYR 460 461 461 TYR TYR A . n A 1 461 ASP 461 462 462 ASP ASP A . n A 1 462 ILE 462 463 463 ILE ILE A . n A 1 463 ALA 463 464 464 ALA ALA A . n A 1 464 LEU 464 465 465 LEU LEU A . n A 1 465 LEU 465 466 466 LEU LEU A . n A 1 466 LYS 466 467 467 LYS LYS A . n A 1 467 LEU 467 468 468 LEU LEU A . n A 1 468 GLU 468 469 469 GLU GLU A . n A 1 469 THR 469 470 470 THR THR A . n A 1 470 THR 470 471 471 THR THR A . n A 1 471 VAL 471 472 472 VAL VAL A . n A 1 472 ASN 472 473 473 ASN ASN A . n A 1 473 TYR 473 474 474 TYR TYR A . n A 1 474 THR 474 475 475 THR THR A . n A 1 475 ASP 475 476 476 ASP ASP A . n A 1 476 SER 476 477 477 SER SER A . n A 1 477 GLN 477 478 478 GLN GLN A . n A 1 478 ARG 478 479 479 ARG ARG A . n A 1 479 PRO 479 480 480 PRO PRO A . n A 1 480 ILE 480 481 481 ILE ILE A . n A 1 481 CYS 481 482 482 CYS CYS A . n A 1 482 LEU 482 483 483 LEU LEU A . n A 1 483 PRO 483 484 484 PRO PRO A . n A 1 484 SER 484 485 485 SER SER A . n A 1 485 LYS 485 486 486 LYS LYS A . n A 1 486 GLY 486 487 487 GLY GLY A . n A 1 487 ASP 487 488 488 ASP ASP A . n A 1 488 ARG 488 489 489 ARG ARG A . n A 1 489 ASN 489 490 490 ASN ASN A . n A 1 490 VAL 490 491 491 VAL VAL A . n A 1 491 ILE 491 492 492 ILE ILE A . n A 1 492 TYR 492 493 493 TYR TYR A . n A 1 493 THR 493 494 494 THR THR A . n A 1 494 ASP 494 495 495 ASP ASP A . n A 1 495 CYS 495 496 496 CYS CYS A . n A 1 496 TRP 496 497 497 TRP TRP A . n A 1 497 VAL 497 498 498 VAL VAL A . n A 1 498 THR 498 499 499 THR THR A . n A 1 499 GLY 499 500 500 GLY GLY A . n A 1 500 TRP 500 501 501 TRP TRP A . n A 1 501 GLY 501 502 502 GLY GLY A . n A 1 502 TYR 502 503 503 TYR TYR A . n A 1 503 ARG 503 504 ? ? ? A . n A 1 504 LYS 504 505 ? ? ? A . n A 1 505 LEU 505 506 ? ? ? A . n A 1 506 ARG 506 507 ? ? ? A . n A 1 507 ASP 507 508 508 ASP ASP A . n A 1 508 LYS 508 509 509 LYS LYS A . n A 1 509 ILE 509 510 510 ILE ILE A . n A 1 510 GLN 510 511 511 GLN GLN A . n A 1 511 ASN 511 512 512 ASN ASN A . n A 1 512 THR 512 513 513 THR THR A . n A 1 513 LEU 513 514 514 LEU LEU A . n A 1 514 GLN 514 515 515 GLN GLN A . n A 1 515 LYS 515 516 516 LYS LYS A . n A 1 516 ALA 516 517 517 ALA ALA A . n A 1 517 LYS 517 518 518 LYS LYS A . n A 1 518 ILE 518 519 519 ILE ILE A . n A 1 519 PRO 519 520 520 PRO PRO A . n A 1 520 LEU 520 521 521 LEU LEU A . n A 1 521 VAL 521 522 522 VAL VAL A . n A 1 522 THR 522 523 523 THR THR A . n A 1 523 ASN 523 524 524 ASN ASN A . n A 1 524 GLU 524 525 525 GLU GLU A . n A 1 525 GLU 525 526 526 GLU GLU A . n A 1 526 CYS 526 527 527 CYS CYS A . n A 1 527 GLN 527 528 528 GLN GLN A . n A 1 528 LYS 528 529 529 LYS LYS A . n A 1 529 ARG 529 530 530 ARG ARG A . n A 1 530 TYR 530 531 531 TYR TYR A . n A 1 531 ARG 531 532 532 ARG ARG A . n A 1 532 GLY 532 533 533 GLY GLY A . n A 1 533 HIS 533 534 534 HIS HIS A . n A 1 534 LYS 534 535 535 LYS LYS A . n A 1 535 ILE 535 536 536 ILE ILE A . n A 1 536 THR 536 537 537 THR THR A . n A 1 537 HIS 537 538 538 HIS HIS A . n A 1 538 LYS 538 539 539 LYS LYS A . n A 1 539 MET 539 540 540 MET MET A . n A 1 540 ILE 540 541 541 ILE ILE A . n A 1 541 CYS 541 542 542 CYS CYS A . n A 1 542 ALA 542 543 543 ALA ALA A . n A 1 543 GLY 543 544 544 GLY GLY A . n A 1 544 TYR 544 545 545 TYR TYR A . n A 1 545 ARG 545 546 ? ? ? A . n A 1 546 GLU 546 547 ? ? ? A . n A 1 547 GLY 547 548 ? ? ? A . n A 1 548 GLY 548 549 ? ? ? A . n A 1 549 LYS 549 550 ? ? ? A . n A 1 550 ASP 550 551 ? ? ? A . n A 1 551 ALA 551 552 ? ? ? A . n A 1 552 CYS 552 553 ? ? ? A . n A 1 553 LYS 553 554 554 LYS LYS A . n A 1 554 GLY 554 555 555 GLY GLY A . n A 1 555 ASP 555 556 556 ASP ASP A . n A 1 556 SER 556 557 557 SER SER A . n A 1 557 GLY 557 558 558 GLY GLY A . n A 1 558 GLY 558 559 559 GLY GLY A . n A 1 559 PRO 559 560 560 PRO PRO A . n A 1 560 LEU 560 561 561 LEU LEU A . n A 1 561 SER 561 562 562 SER SER A . n A 1 562 CYS 562 563 563 CYS CYS A . n A 1 563 LYS 563 564 564 LYS LYS A . n A 1 564 HIS 564 565 565 HIS HIS A . n A 1 565 ASN 565 566 566 ASN ASN A . n A 1 566 GLU 566 567 567 GLU GLU A . n A 1 567 VAL 567 568 568 VAL VAL A . n A 1 568 TRP 568 569 569 TRP TRP A . n A 1 569 HIS 569 570 570 HIS HIS A . n A 1 570 LEU 570 571 571 LEU LEU A . n A 1 571 VAL 571 572 572 VAL VAL A . n A 1 572 GLY 572 573 573 GLY GLY A . n A 1 573 ILE 573 574 574 ILE ILE A . n A 1 574 THR 574 575 575 THR THR A . n A 1 575 SER 575 576 576 SER SER A . n A 1 576 TRP 576 577 577 TRP TRP A . n A 1 577 GLY 577 578 578 GLY GLY A . n A 1 578 GLU 578 579 579 GLU GLU A . n A 1 579 GLY 579 580 580 GLY GLY A . n A 1 580 CYS 580 581 581 CYS CYS A . n A 1 581 ALA 581 582 ? ? ? A . n A 1 582 GLN 582 583 ? ? ? A . n A 1 583 ARG 583 584 ? ? ? A . n A 1 584 GLU 584 585 585 GLU GLU A . n A 1 585 ARG 585 586 586 ARG ARG A . n A 1 586 PRO 586 587 587 PRO PRO A . n A 1 587 GLY 587 588 588 GLY GLY A . n A 1 588 VAL 588 589 589 VAL VAL A . n A 1 589 TYR 589 590 590 TYR TYR A . n A 1 590 THR 590 591 591 THR THR A . n A 1 591 ASN 591 592 592 ASN ASN A . n A 1 592 VAL 592 593 593 VAL VAL A . n A 1 593 VAL 593 594 594 VAL VAL A . n A 1 594 GLU 594 595 595 GLU GLU A . n A 1 595 TYR 595 596 596 TYR TYR A . n A 1 596 VAL 596 597 597 VAL VAL A . n A 1 597 ASP 597 598 598 ASP ASP A . n A 1 598 TRP 598 599 599 TRP TRP A . n A 1 599 ILE 599 600 600 ILE ILE A . n A 1 600 LEU 600 601 601 LEU LEU A . n A 1 601 GLU 601 602 602 GLU GLU A . n A 1 602 LYS 602 603 603 LYS LYS A . n A 1 603 THR 603 604 604 THR THR A . n A 1 604 GLN 604 605 605 GLN GLN A . n A 1 605 ALA 605 606 ? ? ? A . n A 1 606 VAL 606 607 ? ? ? A . n B 2 1 GLU 1 0 0 GLU GLU B . n B 2 2 PHE 2 1 1 PHE PHE B . n B 2 3 PRO 3 2 2 PRO PRO B . n B 2 4 ASP 4 3 3 ASP ASP B . n B 2 5 PHE 5 4 4 PHE PHE B . n B 2 6 PRO 6 5 5 PRO PRO B . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code C 3 NAG 1 901 901 NAG NAG A . D 3 NAG 1 902 910 NAG NAG A . E 3 NAG 1 903 920 NAG NAG A . # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details software_defined_assembly _pdbx_struct_assembly.method_details PISA _pdbx_struct_assembly.oligomeric_details dimeric _pdbx_struct_assembly.oligomeric_count 2 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 1 'ABSA (A^2)' 1420 ? 1 MORE 2 ? 1 'SSA (A^2)' 27970 ? # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2016-04-06 2 'Structure model' 1 1 2016-06-22 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # _pdbx_audit_revision_group.ordinal 1 _pdbx_audit_revision_group.revision_ordinal 2 _pdbx_audit_revision_group.data_content_type 'Structure model' _pdbx_audit_revision_group.group 'Database references' # loop_ _software.citation_id _software.classification _software.compiler_name _software.compiler_version _software.contact_author _software.contact_author_email _software.date _software.description _software.dependencies _software.hardware _software.language _software.location _software.mods _software.name _software.os _software.os_version _software.type _software.version _software.pdbx_ordinal ? refinement ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0131 1 ? refinement ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.10.1-2155 2 ? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS ? ? ? . 3 ? phasing ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? . 4 # loop_ _pdbx_validate_close_contact.id _pdbx_validate_close_contact.PDB_model_num _pdbx_validate_close_contact.auth_atom_id_1 _pdbx_validate_close_contact.auth_asym_id_1 _pdbx_validate_close_contact.auth_comp_id_1 _pdbx_validate_close_contact.auth_seq_id_1 _pdbx_validate_close_contact.PDB_ins_code_1 _pdbx_validate_close_contact.label_alt_id_1 _pdbx_validate_close_contact.auth_atom_id_2 _pdbx_validate_close_contact.auth_asym_id_2 _pdbx_validate_close_contact.auth_comp_id_2 _pdbx_validate_close_contact.auth_seq_id_2 _pdbx_validate_close_contact.PDB_ins_code_2 _pdbx_validate_close_contact.label_alt_id_2 _pdbx_validate_close_contact.dist 1 1 NH2 A ARG 369 ? ? C A GLY 379 ? ? 1.13 2 1 O A LYS 8 ? ? N A ASP 9 ? ? 1.17 3 1 O A GLY 578 ? ? N A GLU 579 ? ? 1.51 4 1 O A LYS 253 ? ? N A SER 254 ? ? 1.52 5 1 O A ARG 378 ? ? N A GLY 379 ? ? 1.59 6 1 O A ILE 366 ? ? CA A LYS 367 ? ? 1.79 7 1 NH2 A ARG 369 ? ? O A GLY 379 ? ? 1.89 8 1 NH2 A ARG 369 ? ? N A GLU 380 ? ? 1.92 9 1 NH2 A ARG 369 ? ? N A GLY 379 ? ? 2.02 10 1 O A ASN 189 ? ? O A LYS 253 ? ? 2.17 # loop_ _pdbx_validate_rmsd_bond.id _pdbx_validate_rmsd_bond.PDB_model_num _pdbx_validate_rmsd_bond.auth_atom_id_1 _pdbx_validate_rmsd_bond.auth_asym_id_1 _pdbx_validate_rmsd_bond.auth_comp_id_1 _pdbx_validate_rmsd_bond.auth_seq_id_1 _pdbx_validate_rmsd_bond.PDB_ins_code_1 _pdbx_validate_rmsd_bond.label_alt_id_1 _pdbx_validate_rmsd_bond.auth_atom_id_2 _pdbx_validate_rmsd_bond.auth_asym_id_2 _pdbx_validate_rmsd_bond.auth_comp_id_2 _pdbx_validate_rmsd_bond.auth_seq_id_2 _pdbx_validate_rmsd_bond.PDB_ins_code_2 _pdbx_validate_rmsd_bond.label_alt_id_2 _pdbx_validate_rmsd_bond.bond_value _pdbx_validate_rmsd_bond.bond_target_value _pdbx_validate_rmsd_bond.bond_deviation _pdbx_validate_rmsd_bond.bond_standard_deviation _pdbx_validate_rmsd_bond.linker_flag 1 1 CA A LYS 8 ? ? CB A LYS 8 ? ? 0.933 1.535 -0.602 0.022 N 2 1 C A LYS 8 ? ? N A ASP 9 ? ? 0.628 1.336 -0.708 0.023 Y 3 1 CA A LYS 252 ? ? CB A LYS 252 ? ? 0.884 1.535 -0.651 0.022 N 4 1 CA A LYS 252 ? ? C A LYS 252 ? ? 1.699 1.525 0.174 0.026 N 5 1 C A LYS 252 ? ? N A LYS 253 ? ? 1.500 1.336 0.164 0.023 Y 6 1 CG A LYS 253 ? ? CD A LYS 253 ? ? 0.428 1.520 -1.092 0.034 N 7 1 CA A LYS 253 ? ? C A LYS 253 ? ? 3.164 1.525 1.639 0.026 N 8 1 C A LYS 253 ? ? N A SER 254 ? ? 0.384 1.336 -0.952 0.023 Y 9 1 CE A LYS 255 ? ? NZ A LYS 255 ? ? 1.659 1.486 0.173 0.025 N 10 1 CB A LEU 257 ? ? CG A LEU 257 ? ? 1.254 1.521 -0.267 0.029 N 11 1 CG A GLN 263 ? ? CD A GLN 263 ? ? 1.982 1.506 0.476 0.023 N 12 1 CA A GLN 318 ? ? C A GLN 318 ? ? 1.728 1.525 0.203 0.026 N 13 1 C A ILE 366 ? ? N A LYS 367 ? ? 0.792 1.336 -0.544 0.023 Y 14 1 C A VAL 371 ? ? N A GLY 372 ? ? 1.521 1.336 0.185 0.023 Y 15 1 CA A ARG 378 ? ? CB A ARG 378 ? ? 0.982 1.535 -0.553 0.022 N 16 1 CA A ARG 378 ? ? C A ARG 378 ? ? 1.717 1.525 0.192 0.026 N 17 1 C A ARG 378 ? ? N A GLY 379 ? ? 0.855 1.336 -0.481 0.023 Y 18 1 C A GLY 578 ? ? N A GLU 579 ? ? 1.188 1.336 -0.148 0.023 Y 19 1 C A GLU 579 ? ? N A GLY 580 ? ? 0.313 1.336 -1.023 0.023 Y # loop_ _pdbx_validate_rmsd_angle.id _pdbx_validate_rmsd_angle.PDB_model_num _pdbx_validate_rmsd_angle.auth_atom_id_1 _pdbx_validate_rmsd_angle.auth_asym_id_1 _pdbx_validate_rmsd_angle.auth_comp_id_1 _pdbx_validate_rmsd_angle.auth_seq_id_1 _pdbx_validate_rmsd_angle.PDB_ins_code_1 _pdbx_validate_rmsd_angle.label_alt_id_1 _pdbx_validate_rmsd_angle.auth_atom_id_2 _pdbx_validate_rmsd_angle.auth_asym_id_2 _pdbx_validate_rmsd_angle.auth_comp_id_2 _pdbx_validate_rmsd_angle.auth_seq_id_2 _pdbx_validate_rmsd_angle.PDB_ins_code_2 _pdbx_validate_rmsd_angle.label_alt_id_2 _pdbx_validate_rmsd_angle.auth_atom_id_3 _pdbx_validate_rmsd_angle.auth_asym_id_3 _pdbx_validate_rmsd_angle.auth_comp_id_3 _pdbx_validate_rmsd_angle.auth_seq_id_3 _pdbx_validate_rmsd_angle.PDB_ins_code_3 _pdbx_validate_rmsd_angle.label_alt_id_3 _pdbx_validate_rmsd_angle.angle_value _pdbx_validate_rmsd_angle.angle_target_value _pdbx_validate_rmsd_angle.angle_deviation _pdbx_validate_rmsd_angle.angle_standard_deviation _pdbx_validate_rmsd_angle.linker_flag 1 1 CB A LYS 8 ? ? CA A LYS 8 ? ? C A LYS 8 ? ? 145.11 110.40 34.71 2.00 N 2 1 CA A LYS 8 ? ? C A LYS 8 ? ? O A LYS 8 ? ? 91.70 120.10 -28.40 2.10 N 3 1 CA A LYS 8 ? ? C A LYS 8 ? ? N A ASP 9 ? ? 142.36 117.20 25.16 2.20 Y 4 1 O A LYS 8 ? ? C A LYS 8 ? ? N A ASP 9 ? ? 69.44 122.70 -53.26 1.60 Y 5 1 C A LYS 8 ? ? N A ASP 9 ? ? CA A ASP 9 ? ? 153.70 121.70 32.00 2.50 Y 6 1 C A TRP 228 ? ? N A PRO 229 ? ? CA A PRO 229 ? ? 129.48 119.30 10.18 1.50 Y 7 1 CB A LYS 252 ? ? CA A LYS 252 ? ? C A LYS 252 ? ? 144.18 110.40 33.78 2.00 N 8 1 N A LYS 252 ? ? CA A LYS 252 ? ? C A LYS 252 ? ? 80.48 111.00 -30.52 2.70 N 9 1 C A LYS 252 ? ? N A LYS 253 ? ? CA A LYS 253 ? ? 80.59 121.70 -41.11 2.50 Y 10 1 CB A LYS 253 ? ? CA A LYS 253 ? ? C A LYS 253 ? ? 76.99 110.40 -33.41 2.00 N 11 1 CB A LYS 253 ? ? CG A LYS 253 ? ? CD A LYS 253 ? ? 155.24 111.60 43.64 2.60 N 12 1 N A LYS 253 ? ? CA A LYS 253 ? ? C A LYS 253 ? ? 47.42 111.00 -63.58 2.70 N 13 1 CA A LYS 253 ? ? C A LYS 253 ? ? N A SER 254 ? ? 85.31 117.20 -31.89 2.20 Y 14 1 O A LYS 253 ? ? C A LYS 253 ? ? N A SER 254 ? ? 139.08 122.70 16.38 1.60 Y 15 1 C A LYS 253 ? ? N A SER 254 ? ? CA A SER 254 ? ? 95.10 121.70 -26.60 2.50 Y 16 1 CD A LYS 255 ? ? CE A LYS 255 ? ? NZ A LYS 255 ? ? 84.61 111.70 -27.09 2.30 N 17 1 CB A LEU 257 ? ? CG A LEU 257 ? ? CD2 A LEU 257 ? ? 100.71 111.00 -10.29 1.70 N 18 1 CA A GLN 263 ? ? CB A GLN 263 ? ? CG A GLN 263 ? ? 98.81 113.40 -14.59 2.20 N 19 1 CB A GLN 263 ? ? CG A GLN 263 ? ? CD A GLN 263 ? ? 171.87 111.60 60.27 2.60 N 20 1 CG A GLN 263 ? ? CD A GLN 263 ? ? OE1 A GLN 263 ? ? 65.66 121.60 -55.94 2.00 N 21 1 CG A GLN 263 ? ? CD A GLN 263 ? ? NE2 A GLN 263 ? ? 150.79 116.70 34.09 2.40 N 22 1 CA A ILE 366 ? ? C A ILE 366 ? ? N A LYS 367 ? ? 149.00 117.20 31.80 2.20 Y 23 1 O A ILE 366 ? ? C A ILE 366 ? ? N A LYS 367 ? ? 85.98 122.70 -36.72 1.60 Y 24 1 N A ILE 370 ? ? CA A ILE 370 ? ? C A ILE 370 ? ? 141.90 111.00 30.90 2.70 N 25 1 CA A VAL 371 ? ? C A VAL 371 ? ? N A GLY 372 ? ? 103.28 116.20 -12.92 2.00 Y 26 1 O A VAL 371 ? ? C A VAL 371 ? ? N A GLY 372 ? ? 138.30 123.20 15.10 1.70 Y 27 1 CB A ARG 378 ? ? CA A ARG 378 ? ? C A ARG 378 ? ? 129.23 110.40 18.83 2.00 N 28 1 CA A ARG 378 ? ? C A ARG 378 ? ? N A GLY 379 ? ? 130.56 116.20 14.36 2.00 Y 29 1 O A ARG 378 ? ? C A ARG 378 ? ? N A GLY 379 ? ? 98.31 123.20 -24.89 1.70 Y 30 1 C A ARG 378 ? ? N A GLY 379 ? ? CA A GLY 379 ? ? 146.45 122.30 24.15 2.10 Y 31 1 CA A GLY 578 ? ? C A GLY 578 ? ? N A GLU 579 ? ? 140.98 117.20 23.78 2.20 Y 32 1 O A GLY 578 ? ? C A GLY 578 ? ? N A GLU 579 ? ? 77.57 122.70 -45.13 1.60 Y 33 1 C A GLY 578 ? ? N A GLU 579 ? ? CA A GLU 579 ? ? 138.39 121.70 16.69 2.50 Y 34 1 CA A GLU 579 ? ? C A GLU 579 ? ? N A GLY 580 ? ? 51.85 116.20 -64.35 2.00 Y 35 1 O A GLU 579 ? ? C A GLU 579 ? ? N A GLY 580 ? ? 104.40 123.20 -18.80 1.70 Y 36 1 C A GLU 579 ? ? N A GLY 580 ? ? CA A GLY 580 ? ? 72.16 122.30 -50.14 2.10 Y # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 LEU A 6 ? ? -103.40 -168.09 2 1 LYS A 8 ? ? -41.47 -144.19 3 1 ASP A 16 ? ? -25.45 100.76 4 1 ILE A 17 ? ? -92.84 -65.73 5 1 PRO A 48 ? ? -27.29 -55.56 6 1 GLU A 66 ? ? 85.30 -3.07 7 1 ALA A 75 ? ? 81.72 -6.63 8 1 PRO A 139 ? ? -36.15 -87.63 9 1 ARG A 144 ? ? -33.69 126.44 10 1 ASN A 145 ? ? 80.83 -6.92 11 1 ASN A 189 ? ? 50.89 12.51 12 1 ASP A 194 ? ? -138.48 -149.31 13 1 ASP A 198 ? ? 178.75 166.22 14 1 SER A 225 ? ? -55.00 170.01 15 1 PRO A 229 ? ? -31.49 -87.75 16 1 CYS A 265 ? ? -97.77 34.73 17 1 SER A 268 ? ? 83.57 -12.28 18 1 VAL A 271 ? ? -132.03 -52.42 19 1 ARG A 354 ? ? -41.85 -19.00 20 1 ILE A 370 ? ? 32.51 139.04 21 1 THR A 374 ? ? -142.82 -34.05 22 1 ARG A 378 ? ? 15.42 -105.26 23 1 PRO A 382 ? ? -54.79 -9.65 24 1 LEU A 431 ? ? -116.41 -70.43 25 1 THR A 440 ? ? -38.46 123.99 26 1 GLN A 453 ? ? 85.38 -8.94 27 1 LYS A 455 ? ? -128.11 -57.72 28 1 TYR A 461 ? ? -77.78 49.21 29 1 TRP A 501 ? ? -108.04 -157.18 30 1 GLN A 528 ? ? -38.86 -39.44 31 1 ARG A 532 ? ? -58.94 -72.03 32 1 TRP A 577 ? ? 51.46 -139.62 33 1 GLU A 579 ? ? -146.59 53.23 # loop_ _pdbx_validate_peptide_omega.id _pdbx_validate_peptide_omega.PDB_model_num _pdbx_validate_peptide_omega.auth_comp_id_1 _pdbx_validate_peptide_omega.auth_asym_id_1 _pdbx_validate_peptide_omega.auth_seq_id_1 _pdbx_validate_peptide_omega.PDB_ins_code_1 _pdbx_validate_peptide_omega.label_alt_id_1 _pdbx_validate_peptide_omega.auth_comp_id_2 _pdbx_validate_peptide_omega.auth_asym_id_2 _pdbx_validate_peptide_omega.auth_seq_id_2 _pdbx_validate_peptide_omega.PDB_ins_code_2 _pdbx_validate_peptide_omega.label_alt_id_2 _pdbx_validate_peptide_omega.omega 1 1 LYS A 8 ? ? ASP A 9 ? ? -134.06 2 1 GLU A 579 ? ? GLY A 580 ? ? 130.14 # loop_ _pdbx_validate_main_chain_plane.id _pdbx_validate_main_chain_plane.PDB_model_num _pdbx_validate_main_chain_plane.auth_comp_id _pdbx_validate_main_chain_plane.auth_asym_id _pdbx_validate_main_chain_plane.auth_seq_id _pdbx_validate_main_chain_plane.PDB_ins_code _pdbx_validate_main_chain_plane.label_alt_id _pdbx_validate_main_chain_plane.improper_torsion_angle 1 1 LYS A 8 ? ? -108.72 2 1 LYS A 252 ? ? -15.93 3 1 LYS A 253 ? ? -24.55 4 1 ILE A 366 ? ? -18.05 5 1 ARG A 378 ? ? 29.07 6 1 GLY A 578 ? ? 46.89 7 1 GLU A 579 ? ? 74.41 # _pdbx_validate_planes.id 1 _pdbx_validate_planes.PDB_model_num 1 _pdbx_validate_planes.auth_comp_id GLN _pdbx_validate_planes.auth_asym_id A _pdbx_validate_planes.auth_seq_id 263 _pdbx_validate_planes.PDB_ins_code ? _pdbx_validate_planes.label_alt_id ? _pdbx_validate_planes.rmsd 0.139 _pdbx_validate_planes.type 'SIDE CHAIN' # loop_ _pdbx_validate_chiral.id _pdbx_validate_chiral.PDB_model_num _pdbx_validate_chiral.auth_atom_id _pdbx_validate_chiral.label_alt_id _pdbx_validate_chiral.auth_asym_id _pdbx_validate_chiral.auth_comp_id _pdbx_validate_chiral.auth_seq_id _pdbx_validate_chiral.PDB_ins_code _pdbx_validate_chiral.details _pdbx_validate_chiral.omega 1 1 CA ? A LYS 8 ? 'WRONG HAND' . 2 1 C1 ? A NAG 901 ? PLANAR . 3 1 C1 ? A NAG 902 ? PLANAR . # loop_ _pdbx_validate_polymer_linkage.id _pdbx_validate_polymer_linkage.PDB_model_num _pdbx_validate_polymer_linkage.auth_atom_id_1 _pdbx_validate_polymer_linkage.auth_asym_id_1 _pdbx_validate_polymer_linkage.auth_comp_id_1 _pdbx_validate_polymer_linkage.auth_seq_id_1 _pdbx_validate_polymer_linkage.PDB_ins_code_1 _pdbx_validate_polymer_linkage.label_alt_id_1 _pdbx_validate_polymer_linkage.auth_atom_id_2 _pdbx_validate_polymer_linkage.auth_asym_id_2 _pdbx_validate_polymer_linkage.auth_comp_id_2 _pdbx_validate_polymer_linkage.auth_seq_id_2 _pdbx_validate_polymer_linkage.PDB_ins_code_2 _pdbx_validate_polymer_linkage.label_alt_id_2 _pdbx_validate_polymer_linkage.dist 1 1 C A LYS 8 ? ? N A ASP 9 ? ? 0.63 2 1 C A LYS 253 ? ? N A SER 254 ? ? 0.38 3 1 C A ILE 366 ? ? N A LYS 367 ? ? 0.79 4 1 C A LYS 367 ? ? N A PRO 368 ? ? 2.39 5 1 C A PRO 368 ? ? N A ARG 369 ? ? 1.73 6 1 C A ARG 378 ? ? N A GLY 379 ? ? 0.86 7 1 C A GLY 578 ? ? N A GLU 579 ? ? 1.19 8 1 C A GLU 579 ? ? N A GLY 580 ? ? 0.31 # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 Y 0 A LYS 8 ? C ? A LYS 7 C 2 1 Y 0 A LYS 8 ? O ? A LYS 7 O 3 1 Y 0 A LYS 8 ? CB ? A LYS 7 CB 4 1 Y 0 A LYS 8 ? CG ? A LYS 7 CG 5 1 Y 0 A LYS 8 ? CD ? A LYS 7 CD 6 1 Y 0 A LYS 8 ? CE ? A LYS 7 CE 7 1 Y 0 A LYS 8 ? NZ ? A LYS 7 NZ 8 1 Y 0 A LYS 252 ? C ? A LYS 251 C 9 1 Y 0 A LYS 252 ? O ? A LYS 251 O 10 1 Y 0 A LYS 252 ? CB ? A LYS 251 CB 11 1 Y 0 A LYS 252 ? CG ? A LYS 251 CG 12 1 Y 0 A LYS 252 ? CD ? A LYS 251 CD 13 1 Y 0 A LYS 252 ? CE ? A LYS 251 CE 14 1 Y 0 A LYS 252 ? NZ ? A LYS 251 NZ 15 1 Y 0 A LYS 253 ? C ? A LYS 252 C 16 1 Y 0 A LYS 253 ? O ? A LYS 252 O 17 1 Y 0 A LYS 253 ? CD ? A LYS 252 CD 18 1 Y 0 A LYS 253 ? CE ? A LYS 252 CE 19 1 Y 0 A LYS 253 ? NZ ? A LYS 252 NZ 20 1 Y 0 A LYS 255 ? NZ ? A LYS 254 NZ 21 1 Y 0 A LEU 257 ? CG ? A LEU 256 CG 22 1 Y 0 A LEU 257 ? CD1 ? A LEU 256 CD1 23 1 Y 0 A LEU 257 ? CD2 ? A LEU 256 CD2 24 1 Y 0 A GLN 263 ? CG ? A GLN 262 CG 25 1 Y 1 A GLN 318 ? CB ? A GLN 317 CB 26 1 Y 1 A GLN 318 ? CG ? A GLN 317 CG 27 1 Y 1 A GLN 318 ? CD ? A GLN 317 CD 28 1 Y 1 A GLN 318 ? OE1 ? A GLN 317 OE1 29 1 Y 1 A GLN 318 ? NE2 ? A GLN 317 NE2 30 1 Y 0 A ARG 378 ? C ? A ARG 377 C 31 1 Y 0 A ARG 378 ? O ? A ARG 377 O 32 1 Y 0 A ARG 378 ? CB ? A ARG 377 CB 33 1 Y 0 A ARG 378 ? CG ? A ARG 377 CG 34 1 Y 0 A ARG 378 ? CD ? A ARG 377 CD 35 1 Y 0 A ARG 378 ? NE ? A ARG 377 NE 36 1 Y 0 A ARG 378 ? CZ ? A ARG 377 CZ 37 1 Y 0 A ARG 378 ? NH1 ? A ARG 377 NH1 38 1 Y 0 A ARG 378 ? NH2 ? A ARG 377 NH2 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A ALA 319 ? A ALA 318 2 1 Y 1 A SER 320 ? A SER 319 3 1 Y 1 A CYS 321 ? A CYS 320 4 1 Y 0 A LYS 367 ? A LYS 366 5 1 Y 0 A ARG 369 ? A ARG 368 6 1 Y 0 A ILE 370 ? A ILE 369 7 1 Y 0 A VAL 371 ? A VAL 370 8 1 Y 1 A ARG 504 ? A ARG 503 9 1 Y 1 A LYS 505 ? A LYS 504 10 1 Y 1 A LEU 506 ? A LEU 505 11 1 Y 1 A ARG 507 ? A ARG 506 12 1 Y 1 A ARG 546 ? A ARG 545 13 1 Y 1 A GLU 547 ? A GLU 546 14 1 Y 1 A GLY 548 ? A GLY 547 15 1 Y 1 A GLY 549 ? A GLY 548 16 1 Y 1 A LYS 550 ? A LYS 549 17 1 Y 1 A ASP 551 ? A ASP 550 18 1 Y 1 A ALA 552 ? A ALA 551 19 1 Y 1 A CYS 553 ? A CYS 552 20 1 Y 0 A GLU 579 ? A GLU 578 21 1 Y 1 A ALA 582 ? A ALA 581 22 1 Y 1 A GLN 583 ? A GLN 582 23 1 Y 1 A ARG 584 ? A ARG 583 24 1 Y 1 A ALA 606 ? A ALA 605 25 1 Y 1 A VAL 607 ? A VAL 606 # _pdbx_entity_nonpoly.entity_id 3 _pdbx_entity_nonpoly.name N-ACETYL-D-GLUCOSAMINE _pdbx_entity_nonpoly.comp_id NAG #