data_5A2R # _entry.id 5A2R # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 5A2R PDBE EBI-63836 WWPDB D_1290063836 # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 5A2R _pdbx_database_status.deposit_site PDBE _pdbx_database_status.process_site PDBE _pdbx_database_status.SG_entry . _pdbx_database_status.recvd_initial_deposition_date 2015-05-22 _pdbx_database_status.pdb_format_compatible Y _pdbx_database_status.status_code_sf ? _pdbx_database_status.status_code_mr ? _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Harrison, C.' 1 'Acharya, K.R.' 2 # _citation.id primary _citation.title 'A New High-Resolution Crystal Structure of the Drosophila Melanogaster Angiotensin Converting Enzyme Homologue, Ance.' _citation.journal_abbrev 'FEBS Open Bio' _citation.journal_volume 5 _citation.page_first 661 _citation.page_last ? _citation.year 2015 _citation.journal_id_ASTM ? _citation.country NE _citation.journal_id_ISSN 2211-5463 _citation.journal_id_CSD ? _citation.book_publisher ? _citation.pdbx_database_id_PubMed 26380810 _citation.pdbx_database_id_DOI 10.1016/J.FOB.2015.08.004 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Harrison, C.' 1 primary 'Acharya, K.R.' 2 # _cell.entry_id 5A2R _cell.length_a 86.120 _cell.length_b 94.900 _cell.length_c 99.030 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 90.00 _cell.Z_PDB 4 _cell.pdbx_unique_axis ? # _symmetry.entry_id 5A2R _symmetry.space_group_name_H-M 'P 21 21 21' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 19 # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'ANGIOTENSIN-CONVERTING ENZYME' 69168.602 1 3.4.15.1 ? 'RESIDUES 18-615' ? 2 non-polymer syn D-MALATE 134.087 1 ? ? ? ? 3 non-polymer syn 'ZINC ION' 65.409 1 ? ? ? ? 4 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 2 ? ? ? ? 5 non-polymer syn 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL 122.143 1 ? ? ? ? 6 water nat water 18.015 705 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name 'DIPEPTIDYL CARBOXYPEPTIDASE I, KININASE II, ANGIOTENSIN CON VERTING ENZYME' # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;LVKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQF KALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAV RSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMH LLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCH ASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLL KDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYH ISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIM SGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNKCVSS ; _entity_poly.pdbx_seq_one_letter_code_can ;LVKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQF KALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAV RSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMH LLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCH ASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLL KDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYH ISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIM SGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNKCVSS ; _entity_poly.pdbx_strand_id A _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 LEU n 1 2 VAL n 1 3 LYS n 1 4 GLU n 1 5 GLU n 1 6 ILE n 1 7 GLN n 1 8 ALA n 1 9 LYS n 1 10 GLU n 1 11 TYR n 1 12 LEU n 1 13 GLU n 1 14 ASN n 1 15 LEU n 1 16 ASN n 1 17 LYS n 1 18 GLU n 1 19 LEU n 1 20 ALA n 1 21 LYS n 1 22 ARG n 1 23 THR n 1 24 ASN n 1 25 VAL n 1 26 GLU n 1 27 THR n 1 28 GLU n 1 29 ALA n 1 30 ALA n 1 31 TRP n 1 32 ALA n 1 33 TYR n 1 34 GLY n 1 35 SER n 1 36 ASN n 1 37 ILE n 1 38 THR n 1 39 ASP n 1 40 GLU n 1 41 ASN n 1 42 GLU n 1 43 LYS n 1 44 LYS n 1 45 LYS n 1 46 ASN n 1 47 GLU n 1 48 ILE n 1 49 SER n 1 50 ALA n 1 51 GLU n 1 52 LEU n 1 53 ALA n 1 54 LYS n 1 55 PHE n 1 56 MET n 1 57 LYS n 1 58 GLU n 1 59 VAL n 1 60 ALA n 1 61 SER n 1 62 ASP n 1 63 THR n 1 64 THR n 1 65 LYS n 1 66 PHE n 1 67 GLN n 1 68 TRP n 1 69 ARG n 1 70 SER n 1 71 TYR n 1 72 GLN n 1 73 SER n 1 74 GLU n 1 75 ASP n 1 76 LEU n 1 77 LYS n 1 78 ARG n 1 79 GLN n 1 80 PHE n 1 81 LYS n 1 82 ALA n 1 83 LEU n 1 84 THR n 1 85 LYS n 1 86 LEU n 1 87 GLY n 1 88 TYR n 1 89 ALA n 1 90 ALA n 1 91 LEU n 1 92 PRO n 1 93 GLU n 1 94 ASP n 1 95 ASP n 1 96 TYR n 1 97 ALA n 1 98 GLU n 1 99 LEU n 1 100 LEU n 1 101 ASP n 1 102 THR n 1 103 LEU n 1 104 SER n 1 105 ALA n 1 106 MET n 1 107 GLU n 1 108 SER n 1 109 ASN n 1 110 PHE n 1 111 ALA n 1 112 LYS n 1 113 VAL n 1 114 LYS n 1 115 VAL n 1 116 CYS n 1 117 ASP n 1 118 TYR n 1 119 LYS n 1 120 ASP n 1 121 SER n 1 122 THR n 1 123 LYS n 1 124 CYS n 1 125 ASP n 1 126 LEU n 1 127 ALA n 1 128 LEU n 1 129 ASP n 1 130 PRO n 1 131 GLU n 1 132 ILE n 1 133 GLU n 1 134 GLU n 1 135 VAL n 1 136 ILE n 1 137 SER n 1 138 LYS n 1 139 SER n 1 140 ARG n 1 141 ASP n 1 142 HIS n 1 143 GLU n 1 144 GLU n 1 145 LEU n 1 146 ALA n 1 147 TYR n 1 148 TYR n 1 149 TRP n 1 150 ARG n 1 151 GLU n 1 152 PHE n 1 153 TYR n 1 154 ASP n 1 155 LYS n 1 156 ALA n 1 157 GLY n 1 158 THR n 1 159 ALA n 1 160 VAL n 1 161 ARG n 1 162 SER n 1 163 GLN n 1 164 PHE n 1 165 GLU n 1 166 ARG n 1 167 TYR n 1 168 VAL n 1 169 GLU n 1 170 LEU n 1 171 ASN n 1 172 THR n 1 173 LYS n 1 174 ALA n 1 175 ALA n 1 176 LYS n 1 177 LEU n 1 178 ASN n 1 179 ASN n 1 180 PHE n 1 181 THR n 1 182 SER n 1 183 GLY n 1 184 ALA n 1 185 GLU n 1 186 ALA n 1 187 TRP n 1 188 LEU n 1 189 ASP n 1 190 GLU n 1 191 TYR n 1 192 GLU n 1 193 ASP n 1 194 ASP n 1 195 THR n 1 196 PHE n 1 197 GLU n 1 198 GLN n 1 199 GLN n 1 200 LEU n 1 201 GLU n 1 202 ASP n 1 203 ILE n 1 204 PHE n 1 205 ALA n 1 206 ASP n 1 207 ILE n 1 208 ARG n 1 209 PRO n 1 210 LEU n 1 211 TYR n 1 212 GLN n 1 213 GLN n 1 214 ILE n 1 215 HIS n 1 216 GLY n 1 217 TYR n 1 218 VAL n 1 219 ARG n 1 220 PHE n 1 221 ARG n 1 222 LEU n 1 223 ARG n 1 224 LYS n 1 225 HIS n 1 226 TYR n 1 227 GLY n 1 228 ASP n 1 229 ALA n 1 230 VAL n 1 231 VAL n 1 232 SER n 1 233 GLU n 1 234 THR n 1 235 GLY n 1 236 PRO n 1 237 ILE n 1 238 PRO n 1 239 MET n 1 240 HIS n 1 241 LEU n 1 242 LEU n 1 243 GLY n 1 244 ASN n 1 245 MET n 1 246 TRP n 1 247 ALA n 1 248 GLN n 1 249 GLN n 1 250 TRP n 1 251 SER n 1 252 GLU n 1 253 ILE n 1 254 ALA n 1 255 ASP n 1 256 ILE n 1 257 VAL n 1 258 SER n 1 259 PRO n 1 260 PHE n 1 261 PRO n 1 262 GLU n 1 263 LYS n 1 264 PRO n 1 265 LEU n 1 266 VAL n 1 267 ASP n 1 268 VAL n 1 269 SER n 1 270 ALA n 1 271 GLU n 1 272 MET n 1 273 GLU n 1 274 LYS n 1 275 GLN n 1 276 GLY n 1 277 TYR n 1 278 THR n 1 279 PRO n 1 280 LEU n 1 281 LYS n 1 282 MET n 1 283 PHE n 1 284 GLN n 1 285 MET n 1 286 GLY n 1 287 ASP n 1 288 ASP n 1 289 PHE n 1 290 PHE n 1 291 THR n 1 292 SER n 1 293 MET n 1 294 ASN n 1 295 LEU n 1 296 THR n 1 297 LYS n 1 298 LEU n 1 299 PRO n 1 300 GLN n 1 301 ASP n 1 302 PHE n 1 303 TRP n 1 304 ASP n 1 305 LYS n 1 306 SER n 1 307 ILE n 1 308 ILE n 1 309 GLU n 1 310 LYS n 1 311 PRO n 1 312 THR n 1 313 ASP n 1 314 GLY n 1 315 ARG n 1 316 ASP n 1 317 LEU n 1 318 VAL n 1 319 CYS n 1 320 HIS n 1 321 ALA n 1 322 SER n 1 323 ALA n 1 324 TRP n 1 325 ASP n 1 326 PHE n 1 327 TYR n 1 328 LEU n 1 329 THR n 1 330 ASP n 1 331 ASP n 1 332 VAL n 1 333 ARG n 1 334 ILE n 1 335 LYS n 1 336 GLN n 1 337 CYS n 1 338 THR n 1 339 ARG n 1 340 VAL n 1 341 THR n 1 342 GLN n 1 343 ASP n 1 344 GLN n 1 345 LEU n 1 346 PHE n 1 347 THR n 1 348 VAL n 1 349 HIS n 1 350 HIS n 1 351 GLU n 1 352 LEU n 1 353 GLY n 1 354 HIS n 1 355 ILE n 1 356 GLN n 1 357 TYR n 1 358 PHE n 1 359 LEU n 1 360 GLN n 1 361 TYR n 1 362 GLN n 1 363 HIS n 1 364 GLN n 1 365 PRO n 1 366 PHE n 1 367 VAL n 1 368 TYR n 1 369 ARG n 1 370 THR n 1 371 GLY n 1 372 ALA n 1 373 ASN n 1 374 PRO n 1 375 GLY n 1 376 PHE n 1 377 HIS n 1 378 GLU n 1 379 ALA n 1 380 VAL n 1 381 GLY n 1 382 ASP n 1 383 VAL n 1 384 LEU n 1 385 SER n 1 386 LEU n 1 387 SER n 1 388 VAL n 1 389 SER n 1 390 THR n 1 391 PRO n 1 392 LYS n 1 393 HIS n 1 394 LEU n 1 395 GLU n 1 396 LYS n 1 397 ILE n 1 398 GLY n 1 399 LEU n 1 400 LEU n 1 401 LYS n 1 402 ASP n 1 403 TYR n 1 404 VAL n 1 405 ARG n 1 406 ASP n 1 407 ASP n 1 408 GLU n 1 409 ALA n 1 410 ARG n 1 411 ILE n 1 412 ASN n 1 413 GLN n 1 414 LEU n 1 415 PHE n 1 416 LEU n 1 417 THR n 1 418 ALA n 1 419 LEU n 1 420 ASP n 1 421 LYS n 1 422 ILE n 1 423 VAL n 1 424 PHE n 1 425 LEU n 1 426 PRO n 1 427 PHE n 1 428 ALA n 1 429 PHE n 1 430 THR n 1 431 MET n 1 432 ASP n 1 433 LYS n 1 434 TYR n 1 435 ARG n 1 436 TRP n 1 437 SER n 1 438 LEU n 1 439 PHE n 1 440 ARG n 1 441 GLY n 1 442 GLU n 1 443 VAL n 1 444 ASP n 1 445 LYS n 1 446 ALA n 1 447 ASN n 1 448 TRP n 1 449 ASN n 1 450 CYS n 1 451 ALA n 1 452 PHE n 1 453 TRP n 1 454 LYS n 1 455 LEU n 1 456 ARG n 1 457 ASP n 1 458 GLU n 1 459 TYR n 1 460 SER n 1 461 GLY n 1 462 ILE n 1 463 GLU n 1 464 PRO n 1 465 PRO n 1 466 VAL n 1 467 VAL n 1 468 ARG n 1 469 SER n 1 470 GLU n 1 471 LYS n 1 472 ASP n 1 473 PHE n 1 474 ASP n 1 475 ALA n 1 476 PRO n 1 477 ALA n 1 478 LYS n 1 479 TYR n 1 480 HIS n 1 481 ILE n 1 482 SER n 1 483 ALA n 1 484 ASP n 1 485 VAL n 1 486 GLU n 1 487 TYR n 1 488 LEU n 1 489 ARG n 1 490 TYR n 1 491 LEU n 1 492 VAL n 1 493 SER n 1 494 PHE n 1 495 ILE n 1 496 ILE n 1 497 GLN n 1 498 PHE n 1 499 GLN n 1 500 PHE n 1 501 TYR n 1 502 LYS n 1 503 SER n 1 504 ALA n 1 505 CYS n 1 506 ILE n 1 507 LYS n 1 508 ALA n 1 509 GLY n 1 510 GLN n 1 511 TYR n 1 512 ASP n 1 513 PRO n 1 514 ASP n 1 515 ASN n 1 516 VAL n 1 517 GLU n 1 518 LEU n 1 519 PRO n 1 520 LEU n 1 521 ASP n 1 522 ASN n 1 523 CYS n 1 524 ASP n 1 525 ILE n 1 526 TYR n 1 527 GLY n 1 528 SER n 1 529 ALA n 1 530 ALA n 1 531 ALA n 1 532 GLY n 1 533 ALA n 1 534 ALA n 1 535 PHE n 1 536 HIS n 1 537 ASN n 1 538 MET n 1 539 LEU n 1 540 SER n 1 541 MET n 1 542 GLY n 1 543 ALA n 1 544 SER n 1 545 LYS n 1 546 PRO n 1 547 TRP n 1 548 PRO n 1 549 ASP n 1 550 ALA n 1 551 LEU n 1 552 GLU n 1 553 ALA n 1 554 PHE n 1 555 ASN n 1 556 GLY n 1 557 GLU n 1 558 ARG n 1 559 ILE n 1 560 MET n 1 561 SER n 1 562 GLY n 1 563 LYS n 1 564 ALA n 1 565 ILE n 1 566 ALA n 1 567 GLU n 1 568 TYR n 1 569 PHE n 1 570 GLU n 1 571 PRO n 1 572 LEU n 1 573 ARG n 1 574 VAL n 1 575 TRP n 1 576 LEU n 1 577 GLU n 1 578 ALA n 1 579 GLU n 1 580 ASN n 1 581 ILE n 1 582 LYS n 1 583 ASN n 1 584 ASN n 1 585 VAL n 1 586 HIS n 1 587 ILE n 1 588 GLY n 1 589 TRP n 1 590 THR n 1 591 THR n 1 592 SER n 1 593 ASN n 1 594 LYS n 1 595 CYS n 1 596 VAL n 1 597 SER n 1 598 SER n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name 'FRUIT FLY' _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene ? _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'DROSOPHILA MELANOGASTER' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 7227 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'KOMAGATAELLA PASTORIS GS115' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 644223 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain ? _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type PLASMID _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name PPIC9 _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code ACE_DROME _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ? _struct_ref.pdbx_align_begin ? _struct_ref.pdbx_db_accession Q10714 _struct_ref.pdbx_db_isoform ? # _struct_ref_seq.align_id 1 _struct_ref_seq.ref_id 1 _struct_ref_seq.pdbx_PDB_id_code 5A2R _struct_ref_seq.pdbx_strand_id A _struct_ref_seq.seq_align_beg 1 _struct_ref_seq.pdbx_seq_align_beg_ins_code ? _struct_ref_seq.seq_align_end 598 _struct_ref_seq.pdbx_seq_align_end_ins_code ? _struct_ref_seq.pdbx_db_accession Q10714 _struct_ref_seq.db_align_beg 18 _struct_ref_seq.pdbx_db_align_beg_ins_code ? _struct_ref_seq.db_align_end 615 _struct_ref_seq.pdbx_db_align_end_ins_code ? _struct_ref_seq.pdbx_auth_seq_align_beg 18 _struct_ref_seq.pdbx_auth_seq_align_end 615 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 MLT non-polymer . D-MALATE '(2R)-2-HYDROXYBUTANEDIOIC ACID; 2-HYDROXY-SUCCINIC ACID' 'C4 H6 O5' 134.087 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TRS non-polymer . 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL 'TRIS BUFFER' 'C4 H12 N O3 1' 122.143 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 ZN non-polymer . 'ZINC ION' ? 'Zn 2' 65.409 # _exptl.entry_id 5A2R _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 2.85 _exptl_crystal.density_percent_sol 56.87 _exptl_crystal.description NONE # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method ? _exptl_crystal_grow.temp ? _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 4 _exptl_crystal_grow.pdbx_pH_range ? _exptl_crystal_grow.pdbx_details '25 % W/V PEG 1500, 0.1 M MMT PH 4.0' # _diffrn.id 1 _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector PIXEL _diffrn_detector.type 'DECTRIS PILATUS 6M' _diffrn_detector.pdbx_collection_date 2013-03-17 _diffrn_detector.details ? # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator SI _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 1.000 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'DIAMOND BEAMLINE I24' _diffrn_source.pdbx_synchrotron_site Diamond _diffrn_source.pdbx_synchrotron_beamline I24 _diffrn_source.pdbx_wavelength 1.000 _diffrn_source.pdbx_wavelength_list ? # _reflns.pdbx_diffrn_id 1 _reflns.pdbx_ordinal 1 _reflns.entry_id 5A2R _reflns.observed_criterion_sigma_I 6.0 _reflns.observed_criterion_sigma_F ? _reflns.d_resolution_low 68.52 _reflns.d_resolution_high 1.85 _reflns.number_obs 68121 _reflns.number_all ? _reflns.percent_possible_obs 97.8 _reflns.pdbx_Rmerge_I_obs 0.06 _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI 10.60 _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy 3.2 # _reflns_shell.pdbx_diffrn_id 1 _reflns_shell.pdbx_ordinal 1 _reflns_shell.d_res_high 1.85 _reflns_shell.d_res_low 1.89 _reflns_shell.percent_possible_all 89.5 _reflns_shell.Rmerge_I_obs 0.59 _reflns_shell.pdbx_Rsym_value ? _reflns_shell.meanI_over_sigI_obs 2.20 _reflns_shell.pdbx_redundancy 2.2 # _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.entry_id 5A2R _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.ls_number_reflns_obs 64614 _refine.ls_number_reflns_all ? _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F . _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 68.52 _refine.ls_d_res_high 1.85 _refine.ls_percent_reflns_obs 97.33 _refine.ls_R_factor_obs 0.16428 _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work 0.16312 _refine.ls_R_factor_R_free 0.18560 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 5.0 _refine.ls_number_reflns_R_free 3416 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc 0.966 _refine.correlation_coeff_Fo_to_Fc_free 0.957 _refine.B_iso_mean 24.974 _refine.aniso_B[1][1] 2.36 _refine.aniso_B[2][2] -0.22 _refine.aniso_B[3][3] -2.14 _refine.aniso_B[1][2] 0.00 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_details MASK _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.20 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details 'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.' _refine.pdbx_starting_model 'PDB ENTRY 2X8Y' _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R 0.113 _refine.pdbx_overall_ESU_R_Free 0.104 _refine.overall_SU_ML 0.075 _refine.pdbx_overall_phase_error ? _refine.overall_SU_B 2.564 _refine.overall_SU_R_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 4872 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 46 _refine_hist.number_atoms_solvent 705 _refine_hist.number_atoms_total 5623 _refine_hist.d_res_high 1.85 _refine_hist.d_res_low 68.52 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function r_bond_refined_d 0.007 0.019 ? 5047 'X-RAY DIFFRACTION' ? r_bond_other_d 0.002 0.020 ? 4634 'X-RAY DIFFRACTION' ? r_angle_refined_deg 1.277 1.951 ? 6839 'X-RAY DIFFRACTION' ? r_angle_other_deg 0.931 3.000 ? 10683 'X-RAY DIFFRACTION' ? r_dihedral_angle_1_deg 5.484 5.000 ? 596 'X-RAY DIFFRACTION' ? r_dihedral_angle_2_deg 35.460 24.692 ? 260 'X-RAY DIFFRACTION' ? r_dihedral_angle_3_deg 13.208 15.000 ? 856 'X-RAY DIFFRACTION' ? r_dihedral_angle_4_deg 16.429 15.000 ? 24 'X-RAY DIFFRACTION' ? r_chiral_restr 0.133 0.200 ? 721 'X-RAY DIFFRACTION' ? r_gen_planes_refined 0.005 0.020 ? 5704 'X-RAY DIFFRACTION' ? r_gen_planes_other 0.002 0.020 ? 1188 'X-RAY DIFFRACTION' ? r_nbd_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcbond_it 0.975 2.284 ? 2388 'X-RAY DIFFRACTION' ? r_mcbond_other 0.962 2.283 ? 2386 'X-RAY DIFFRACTION' ? r_mcangle_it 1.516 3.419 ? 2982 'X-RAY DIFFRACTION' ? r_mcangle_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_scbond_it 1.592 2.514 ? 2659 'X-RAY DIFFRACTION' ? r_scbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_scangle_it ? ? ? ? 'X-RAY DIFFRACTION' ? r_scangle_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_long_range_B_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_long_range_B_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_rigid_bond_restr ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_free ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_bonded ? ? ? ? 'X-RAY DIFFRACTION' ? # _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.d_res_high 1.850 _refine_ls_shell.d_res_low 1.898 _refine_ls_shell.number_reflns_R_work 4339 _refine_ls_shell.R_factor_R_work 0.249 _refine_ls_shell.percent_reflns_obs 89.82 _refine_ls_shell.R_factor_R_free 0.240 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.number_reflns_R_free 256 _refine_ls_shell.number_reflns_all ? _refine_ls_shell.R_factor_all ? # _struct.entry_id 5A2R _struct.title 'A New Crystal Structure of the Drosophila melanogaster Angiotensin Converting Enzyme Homologue AnCE.' _struct.pdbx_descriptor 'ANGIOTENSIN-CONVERTING ENZYME (E.C.3.4.15.1)' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 5A2R _struct_keywords.pdbx_keywords HYDROLASE _struct_keywords.text ;HYDROLASE, ANGIOTENSIN CONVERTING ENZYME, DROSOPHILA MELANOGASTER, DROSOPHILA PROTEINS, ANIMALS, PEPTIDYL- DIPEPTIDASE A, MOLECULAR STRUCTURE ; # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 3 ? D N N 4 ? E N N 4 ? F N N 5 ? G N N 6 ? # _struct_biol.id 1 # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 LEU A 1 ? ASN A 36 ? LEU A 18 ASN A 53 1 ? 36 HELX_P HELX_P2 2 THR A 38 ? THR A 63 ? THR A 55 THR A 80 1 ? 26 HELX_P HELX_P3 3 THR A 64 ? PHE A 66 ? THR A 81 PHE A 83 5 ? 3 HELX_P HELX_P4 4 GLN A 67 ? TYR A 71 ? GLN A 84 TYR A 88 5 ? 5 HELX_P HELX_P5 5 SER A 73 ? LYS A 85 ? SER A 90 LYS A 102 1 ? 13 HELX_P HELX_P6 6 LEU A 86 ? LEU A 91 ? LEU A 103 LEU A 108 5 ? 6 HELX_P HELX_P7 7 PRO A 92 ? VAL A 113 ? PRO A 109 VAL A 130 1 ? 22 HELX_P HELX_P8 8 PRO A 130 ? SER A 139 ? PRO A 147 SER A 156 1 ? 10 HELX_P HELX_P9 9 ASP A 141 ? GLY A 157 ? ASP A 158 GLY A 174 1 ? 17 HELX_P HELX_P10 10 VAL A 160 ? ASN A 178 ? VAL A 177 ASN A 195 1 ? 19 HELX_P HELX_P11 11 SER A 182 ? ASP A 189 ? SER A 199 ASP A 206 1 ? 8 HELX_P HELX_P12 12 GLU A 190 ? GLU A 192 ? GLU A 207 GLU A 209 5 ? 3 HELX_P HELX_P13 13 THR A 195 ? GLY A 227 ? THR A 212 GLY A 244 1 ? 33 HELX_P HELX_P14 14 HIS A 240 ? LEU A 242 ? HIS A 257 LEU A 259 5 ? 3 HELX_P HELX_P15 15 TRP A 250 ? GLU A 252 ? TRP A 267 GLU A 269 5 ? 3 HELX_P HELX_P16 16 ILE A 253 ? SER A 258 ? ILE A 270 SER A 275 1 ? 6 HELX_P HELX_P17 17 VAL A 268 ? GLN A 275 ? VAL A 285 GLN A 292 1 ? 8 HELX_P HELX_P18 18 THR A 278 ? MET A 293 ? THR A 295 MET A 310 1 ? 16 HELX_P HELX_P19 19 PRO A 299 ? SER A 306 ? PRO A 316 SER A 323 1 ? 8 HELX_P HELX_P20 20 THR A 341 ? TYR A 361 ? THR A 358 TYR A 378 1 ? 21 HELX_P HELX_P21 21 PRO A 365 ? ARG A 369 ? PRO A 382 ARG A 386 5 ? 5 HELX_P HELX_P22 22 ASN A 373 ? SER A 389 ? ASN A 390 SER A 406 1 ? 17 HELX_P HELX_P23 23 THR A 390 ? ILE A 397 ? THR A 407 ILE A 414 1 ? 8 HELX_P HELX_P24 24 ASP A 406 ? ILE A 422 ? ASP A 423 ILE A 439 1 ? 17 HELX_P HELX_P25 25 VAL A 423 ? ARG A 440 ? VAL A 440 ARG A 457 1 ? 18 HELX_P HELX_P26 26 ASP A 444 ? ALA A 446 ? ASP A 461 ALA A 463 5 ? 3 HELX_P HELX_P27 27 ASN A 447 ? GLY A 461 ? ASN A 464 GLY A 478 1 ? 15 HELX_P HELX_P28 28 ASP A 474 ? ALA A 477 ? ASP A 491 ALA A 494 5 ? 4 HELX_P HELX_P29 29 LYS A 478 ? ALA A 483 ? LYS A 495 ALA A 500 1 ? 6 HELX_P HELX_P30 30 TYR A 487 ? ALA A 508 ? TYR A 504 ALA A 525 1 ? 22 HELX_P HELX_P31 31 PRO A 519 ? CYS A 523 ? PRO A 536 CYS A 540 5 ? 5 HELX_P HELX_P32 32 SER A 528 ? SER A 540 ? SER A 545 SER A 557 1 ? 13 HELX_P HELX_P33 33 PRO A 546 ? GLY A 556 ? PRO A 563 GLY A 573 1 ? 11 HELX_P HELX_P34 34 GLY A 562 ? ASN A 583 ? GLY A 579 ASN A 600 1 ? 22 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 116 SG ? ? ? 1_555 A CYS 124 SG ? ? A CYS 133 A CYS 141 1_555 ? ? ? ? ? ? ? 2.036 ? disulf2 disulf ? ? A CYS 319 SG ? ? ? 1_555 A CYS 337 SG ? ? A CYS 336 A CYS 354 1_555 ? ? ? ? ? ? ? 2.052 ? disulf3 disulf ? ? A CYS 450 SG ? ? ? 1_555 A CYS 595 SG ? ? A CYS 467 A CYS 612 1_555 ? ? ? ? ? ? ? 2.093 ? disulf4 disulf ? ? A CYS 505 SG ? ? ? 1_555 A CYS 523 SG ? ? A CYS 522 A CYS 540 1_555 ? ? ? ? ? ? ? 2.029 ? covale1 covale ? ? A ASN 36 ND2 ? ? ? 1_555 E NAG . C1 ? ? A ASN 53 A NAG 1622 1_555 ? ? ? ? ? ? ? 1.439 ? covale2 covale ? ? A ASN 294 ND2 ? ? ? 1_555 D NAG . C1 ? ? A ASN 311 A NAG 1621 1_555 ? ? ? ? ? ? ? 1.453 ? metalc1 metalc ? ? C ZN . ZN ? ? ? 1_555 G HOH . O ? ? A ZN 1616 A HOH 2527 1_555 ? ? ? ? ? ? ? 2.327 ? metalc2 metalc ? ? C ZN . ZN ? ? ? 1_555 A HIS 354 NE2 ? ? A ZN 1616 A HIS 371 1_555 ? ? ? ? ? ? ? 2.072 ? metalc3 metalc ? ? C ZN . ZN ? ? ? 1_555 A GLU 378 OE1 ? ? A ZN 1616 A GLU 395 1_555 ? ? ? ? ? ? ? 1.982 ? metalc4 metalc ? ? C ZN . ZN ? ? ? 1_555 A HIS 350 NE2 ? ? A ZN 1616 A HIS 367 1_555 ? ? ? ? ? ? ? 2.101 ? metalc5 metalc ? ? C ZN . ZN ? ? ? 1_555 G HOH . O ? ? A ZN 1616 A HOH 2528 1_555 ? ? ? ? ? ? ? 2.136 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? metalc ? ? # _struct_mon_prot_cis.pdbx_id 1 _struct_mon_prot_cis.label_comp_id ASP _struct_mon_prot_cis.label_seq_id 129 _struct_mon_prot_cis.label_asym_id A _struct_mon_prot_cis.label_alt_id . _struct_mon_prot_cis.pdbx_PDB_ins_code ? _struct_mon_prot_cis.auth_comp_id ASP _struct_mon_prot_cis.auth_seq_id 146 _struct_mon_prot_cis.auth_asym_id A _struct_mon_prot_cis.pdbx_label_comp_id_2 PRO _struct_mon_prot_cis.pdbx_label_seq_id_2 130 _struct_mon_prot_cis.pdbx_label_asym_id_2 A _struct_mon_prot_cis.pdbx_PDB_ins_code_2 ? _struct_mon_prot_cis.pdbx_auth_comp_id_2 PRO _struct_mon_prot_cis.pdbx_auth_seq_id_2 147 _struct_mon_prot_cis.pdbx_auth_asym_id_2 A _struct_mon_prot_cis.pdbx_PDB_model_num 1 _struct_mon_prot_cis.pdbx_omega_angle 7.52 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details AA ? 2 ? AB ? 2 ? AC ? 2 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense AA 1 2 ? parallel AB 1 2 ? anti-parallel AC 1 2 ? parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id AA 1 ILE A 237 ? PRO A 238 ? ILE A 254 PRO A 255 AA 2 ILE A 462 ? GLU A 463 ? ILE A 479 GLU A 480 AB 1 SER A 322 ? ASP A 325 ? SER A 339 ASP A 342 AB 2 VAL A 332 ? LYS A 335 ? VAL A 349 LYS A 352 AC 1 ARG A 468 ? SER A 469 ? ARG A 485 SER A 486 AC 2 CYS A 595 ? VAL A 596 ? CYS A 612 VAL A 613 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id AA 1 2 O ILE A 237 ? O ILE A 254 N GLU A 463 ? N GLU A 480 AB 1 2 N TRP A 324 ? N TRP A 341 O ARG A 333 ? O ARG A 350 AC 1 2 O ARG A 468 ? O ARG A 485 N VAL A 596 ? N VAL A 613 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE ZN A 1616' AC2 Software ? ? ? ? 9 'BINDING SITE FOR RESIDUE TRS A 7002' AC3 Software ? ? ? ? 8 'BINDING SITE FOR RESIDUE MLT A 1615' AC4 Software ? ? ? ? 6 'Binding site for Mono-Saccharide NAG A1622 bound to ASN A 53' AC5 Software ? ? ? ? 3 'Binding site for Mono-Saccharide NAG A1621 bound to ASN A 311' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 5 HIS A 350 ? HIS A 367 . ? 1_555 ? 2 AC1 5 HIS A 354 ? HIS A 371 . ? 1_555 ? 3 AC1 5 GLU A 378 ? GLU A 395 . ? 1_555 ? 4 AC1 5 HOH G . ? HOH A 2527 . ? 1_555 ? 5 AC1 5 HOH G . ? HOH A 2528 . ? 1_555 ? 6 AC2 9 ARG A 78 ? ARG A 95 . ? 1_555 ? 7 AC2 9 GLU A 190 ? GLU A 207 . ? 1_555 ? 8 AC2 9 GLU A 192 ? GLU A 209 . ? 1_555 ? 9 AC2 9 THR A 370 ? THR A 387 . ? 1_555 ? 10 AC2 9 ALA A 372 ? ALA A 389 . ? 1_555 ? 11 AC2 9 HOH G . ? HOH A 2177 . ? 1_555 ? 12 AC2 9 HOH G . ? HOH A 2186 . ? 1_555 ? 13 AC2 9 HOH G . ? HOH A 2545 . ? 1_555 ? 14 AC2 9 HOH G . ? HOH A 2549 . ? 1_555 ? 15 AC3 8 GLN A 248 ? GLN A 265 . ? 1_555 ? 16 AC3 8 HIS A 320 ? HIS A 337 . ? 1_555 ? 17 AC3 8 GLU A 351 ? GLU A 368 . ? 1_555 ? 18 AC3 8 LYS A 478 ? LYS A 495 . ? 1_555 ? 19 AC3 8 HIS A 480 ? HIS A 497 . ? 1_555 ? 20 AC3 8 TYR A 487 ? TYR A 504 . ? 1_555 ? 21 AC3 8 TYR A 490 ? TYR A 507 . ? 1_555 ? 22 AC3 8 HOH G . ? HOH A 2627 . ? 1_555 ? 23 AC4 6 ASN A 36 ? ASN A 53 . ? 1_555 ? 24 AC4 6 THR A 38 ? THR A 55 . ? 1_555 ? 25 AC4 6 GLU A 40 ? GLU A 57 . ? 1_555 ? 26 AC4 6 ASN A 41 ? ASN A 58 . ? 1_555 ? 27 AC4 6 ARG A 315 ? ARG A 332 . ? 1_555 ? 28 AC4 6 HOH G . ? HOH A 2705 . ? 1_555 ? 29 AC5 3 ASN A 294 ? ASN A 311 . ? 1_555 ? 30 AC5 3 HOH G . ? HOH A 2703 . ? 1_555 ? 31 AC5 3 HOH G . ? HOH A 2704 . ? 1_555 ? # _database_PDB_matrix.entry_id 5A2R _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 5A2R _atom_sites.fract_transf_matrix[1][1] 0.011612 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.010537 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.010098 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C N O S ZN # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . LEU A 1 1 ? 5.071 -30.695 14.360 1.00 50.73 ? 18 LEU A N 1 ATOM 2 C CA . LEU A 1 1 ? 5.570 -29.364 13.884 1.00 50.37 ? 18 LEU A CA 1 ATOM 3 C C . LEU A 1 1 ? 6.964 -29.466 13.243 1.00 48.71 ? 18 LEU A C 1 ATOM 4 O O . LEU A 1 1 ? 7.223 -28.827 12.220 1.00 46.85 ? 18 LEU A O 1 ATOM 5 C CB . LEU A 1 1 ? 5.545 -28.341 15.026 1.00 51.36 ? 18 LEU A CB 1 ATOM 6 C CG . LEU A 1 1 ? 5.770 -26.852 14.711 1.00 51.50 ? 18 LEU A CG 1 ATOM 7 C CD1 . LEU A 1 1 ? 5.046 -26.388 13.454 1.00 52.36 ? 18 LEU A CD1 1 ATOM 8 C CD2 . LEU A 1 1 ? 5.344 -25.997 15.897 1.00 51.93 ? 18 LEU A CD2 1 ATOM 9 N N . VAL A 1 2 ? 7.840 -30.282 13.831 1.00 45.16 ? 19 VAL A N 1 ATOM 10 C CA . VAL A 1 2 ? 9.048 -30.761 13.139 1.00 43.06 ? 19 VAL A CA 1 ATOM 11 C C . VAL A 1 2 ? 8.599 -31.597 11.928 1.00 42.11 ? 19 VAL A C 1 ATOM 12 O O . VAL A 1 2 ? 9.134 -31.448 10.823 1.00 40.20 ? 19 VAL A O 1 ATOM 13 C CB . VAL A 1 2 ? 9.952 -31.630 14.056 1.00 43.93 ? 19 VAL A CB 1 ATOM 14 C CG1 . VAL A 1 2 ? 11.126 -32.225 13.274 1.00 44.17 ? 19 VAL A CG1 1 ATOM 15 C CG2 . VAL A 1 2 ? 10.462 -30.821 15.245 1.00 44.11 ? 19 VAL A CG2 1 ATOM 16 N N . LYS A 1 3 ? 7.615 -32.469 12.162 1.00 40.10 ? 20 LYS A N 1 ATOM 17 C CA . LYS A 1 3 ? 6.984 -33.276 11.111 1.00 39.89 ? 20 LYS A CA 1 ATOM 18 C C . LYS A 1 3 ? 6.347 -32.401 10.033 1.00 36.78 ? 20 LYS A C 1 ATOM 19 O O . LYS A 1 3 ? 6.543 -32.650 8.834 1.00 35.16 ? 20 LYS A O 1 ATOM 20 C CB . LYS A 1 3 ? 5.910 -34.192 11.713 1.00 42.88 ? 20 LYS A CB 1 ATOM 21 C CG . LYS A 1 3 ? 5.258 -35.175 10.736 1.00 46.18 ? 20 LYS A CG 1 ATOM 22 C CD . LYS A 1 3 ? 3.792 -35.420 11.089 1.00 49.70 ? 20 LYS A CD 1 ATOM 23 C CE . LYS A 1 3 ? 3.085 -36.337 10.092 1.00 51.65 ? 20 LYS A CE 1 ATOM 24 N NZ . LYS A 1 3 ? 2.991 -37.748 10.560 1.00 52.81 ? 20 LYS A NZ 1 ATOM 25 N N . GLU A 1 4 ? 5.574 -31.404 10.460 1.00 32.97 ? 21 GLU A N 1 ATOM 26 C CA . GLU A 1 4 ? 4.918 -30.489 9.528 1.00 34.01 ? 21 GLU A CA 1 ATOM 27 C C . GLU A 1 4 ? 5.935 -29.763 8.635 1.00 32.08 ? 21 GLU A C 1 ATOM 28 O O . GLU A 1 4 ? 5.678 -29.564 7.444 1.00 30.32 ? 21 GLU A O 1 ATOM 29 C CB . GLU A 1 4 ? 4.025 -29.480 10.252 1.00 35.98 ? 21 GLU A CB 1 ATOM 30 C CG . GLU A 1 4 ? 2.998 -28.811 9.337 1.00 38.72 ? 21 GLU A CG 1 ATOM 31 C CD . GLU A 1 4 ? 2.272 -27.652 10.001 1.00 39.56 ? 21 GLU A CD 1 ATOM 32 O OE1 . GLU A 1 4 ? 1.428 -27.905 10.888 1.00 45.22 ? 21 GLU A OE1 1 ATOM 33 O OE2 . GLU A 1 4 ? 2.528 -26.489 9.634 1.00 35.74 ? 21 GLU A OE2 1 ATOM 34 N N . GLU A 1 5 ? 7.090 -29.405 9.199 1.00 30.43 ? 22 GLU A N 1 ATOM 35 C CA . GLU A 1 5 ? 8.119 -28.690 8.446 1.00 30.19 ? 22 GLU A CA 1 ATOM 36 C C . GLU A 1 5 ? 8.747 -29.576 7.377 1.00 30.49 ? 22 GLU A C 1 ATOM 37 O O . GLU A 1 5 ? 9.027 -29.109 6.276 1.00 28.91 ? 22 GLU A O 1 ATOM 38 C CB . GLU A 1 5 ? 9.194 -28.100 9.368 1.00 29.53 ? 22 GLU A CB 1 ATOM 39 C CG . GLU A 1 5 ? 10.201 -27.234 8.612 1.00 29.57 ? 22 GLU A CG 1 ATOM 40 C CD . GLU A 1 5 ? 11.023 -26.305 9.486 1.00 30.16 ? 22 GLU A CD 1 ATOM 41 O OE1 . GLU A 1 5 ? 10.764 -26.198 10.704 1.00 28.24 ? 22 GLU A OE1 1 ATOM 42 O OE2 . GLU A 1 5 ? 11.933 -25.647 8.940 1.00 29.06 ? 22 GLU A OE2 1 ATOM 43 N N . ILE A 1 6 ? 8.952 -30.851 7.699 1.00 31.01 ? 23 ILE A N 1 ATOM 44 C CA . ILE A 1 6 ? 9.436 -31.824 6.717 1.00 32.22 ? 23 ILE A CA 1 ATOM 45 C C . ILE A 1 6 ? 8.427 -31.953 5.573 1.00 32.26 ? 23 ILE A C 1 ATOM 46 O O . ILE A 1 6 ? 8.811 -31.930 4.407 1.00 33.48 ? 23 ILE A O 1 ATOM 47 C CB . ILE A 1 6 ? 9.732 -33.196 7.371 1.00 33.99 ? 23 ILE A CB 1 ATOM 48 C CG1 . ILE A 1 6 ? 10.915 -33.076 8.347 1.00 34.68 ? 23 ILE A CG1 1 ATOM 49 C CG2 . ILE A 1 6 ? 10.057 -34.259 6.323 1.00 33.90 ? 23 ILE A CG2 1 ATOM 50 C CD1 . ILE A 1 6 ? 10.948 -34.164 9.402 1.00 35.15 ? 23 ILE A CD1 1 ATOM 51 N N . GLN A 1 7 ? 7.142 -32.053 5.906 1.00 32.02 ? 24 GLN A N 1 ATOM 52 C CA . GLN A 1 7 ? 6.081 -32.108 4.886 1.00 33.44 ? 24 GLN A CA 1 ATOM 53 C C . GLN A 1 7 ? 6.047 -30.834 4.026 1.00 31.38 ? 24 GLN A C 1 ATOM 54 O O . GLN A 1 7 ? 5.919 -30.912 2.802 1.00 28.61 ? 24 GLN A O 1 ATOM 55 C CB . GLN A 1 7 ? 4.709 -32.320 5.529 1.00 37.18 ? 24 GLN A CB 1 ATOM 56 C CG . GLN A 1 7 ? 4.551 -33.664 6.245 1.00 40.89 ? 24 GLN A CG 1 ATOM 57 C CD . GLN A 1 7 ? 3.218 -33.853 6.981 1.00 44.99 ? 24 GLN A CD 1 ATOM 58 O OE1 . GLN A 1 7 ? 2.765 -34.989 7.138 1.00 51.85 ? 24 GLN A OE1 1 ATOM 59 N NE2 . GLN A 1 7 ? 2.591 -32.765 7.440 1.00 44.65 ? 24 GLN A NE2 1 ATOM 60 N N . ALA A 1 8 ? 6.176 -29.674 4.673 1.00 28.96 ? 25 ALA A N 1 ATOM 61 C CA . ALA A 1 8 ? 6.192 -28.375 3.978 1.00 27.78 ? 25 ALA A CA 1 ATOM 62 C C . ALA A 1 8 ? 7.340 -28.251 2.975 1.00 27.05 ? 25 ALA A C 1 ATOM 63 O O . ALA A 1 8 ? 7.167 -27.681 1.898 1.00 26.81 ? 25 ALA A O 1 ATOM 64 C CB . ALA A 1 8 ? 6.251 -27.237 4.991 1.00 27.28 ? 25 ALA A CB 1 ATOM 65 N N . LYS A 1 9 ? 8.507 -28.786 3.331 1.00 26.90 ? 26 LYS A N 1 ATOM 66 C CA . LYS A 1 9 ? 9.664 -28.813 2.435 1.00 27.95 ? 26 LYS A CA 1 ATOM 67 C C . LYS A 1 9 ? 9.400 -29.616 1.149 1.00 28.84 ? 26 LYS A C 1 ATOM 68 O O . LYS A 1 9 ? 9.795 -29.198 0.059 1.00 25.59 ? 26 LYS A O 1 ATOM 69 C CB . LYS A 1 9 ? 10.875 -29.390 3.160 1.00 29.42 ? 26 LYS A CB 1 ATOM 70 C CG . LYS A 1 9 ? 12.191 -29.299 2.406 1.00 31.91 ? 26 LYS A CG 1 ATOM 71 C CD . LYS A 1 9 ? 13.344 -29.744 3.295 1.00 34.42 ? 26 LYS A CD 1 ATOM 72 C CE . LYS A 1 9 ? 14.695 -29.316 2.753 1.00 36.69 ? 26 LYS A CE 1 ATOM 73 N NZ . LYS A 1 9 ? 15.149 -30.194 1.648 1.00 37.89 ? 26 LYS A NZ 1 ATOM 74 N N . GLU A 1 10 ? 8.758 -30.776 1.286 1.00 29.47 ? 27 GLU A N 1 ATOM 75 C CA . GLU A 1 10 ? 8.358 -31.577 0.117 1.00 31.10 ? 27 GLU A CA 1 ATOM 76 C C . GLU A 1 10 ? 7.266 -30.855 -0.671 1.00 27.66 ? 27 GLU A C 1 ATOM 77 O O . GLU A 1 10 ? 7.305 -30.836 -1.895 1.00 27.91 ? 27 GLU A O 1 ATOM 78 C CB . GLU A 1 10 ? 7.925 -33.003 0.521 1.00 35.32 ? 27 GLU A CB 1 ATOM 79 C CG . GLU A 1 10 ? 7.094 -33.761 -0.521 1.00 39.88 ? 27 GLU A CG 1 ATOM 80 C CD . GLU A 1 10 ? 7.678 -35.102 -0.912 1.00 46.73 ? 27 GLU A CD 1 ATOM 81 O OE1 . GLU A 1 10 ? 8.534 -35.123 -1.831 1.00 50.74 ? 27 GLU A OE1 1 ATOM 82 O OE2 . GLU A 1 10 ? 7.277 -36.126 -0.309 1.00 51.21 ? 27 GLU A OE2 1 ATOM 83 N N . TYR A 1 11 ? 6.303 -30.270 0.034 1.00 26.62 ? 28 TYR A N 1 ATOM 84 C CA . TYR A 1 11 ? 5.238 -29.501 -0.598 1.00 26.61 ? 28 TYR A CA 1 ATOM 85 C C . TYR A 1 11 ? 5.790 -28.361 -1.471 1.00 26.46 ? 28 TYR A C 1 ATOM 86 O O . TYR A 1 11 ? 5.342 -28.182 -2.606 1.00 24.72 ? 28 TYR A O 1 ATOM 87 C CB . TYR A 1 11 ? 4.272 -28.958 0.458 1.00 27.97 ? 28 TYR A CB 1 ATOM 88 C CG . TYR A 1 11 ? 3.317 -27.916 -0.055 1.00 29.92 ? 28 TYR A CG 1 ATOM 89 C CD1 . TYR A 1 11 ? 2.090 -28.273 -0.603 1.00 32.05 ? 28 TYR A CD1 1 ATOM 90 C CD2 . TYR A 1 11 ? 3.643 -26.560 0.003 1.00 31.67 ? 28 TYR A CD2 1 ATOM 91 C CE1 . TYR A 1 11 ? 1.211 -27.308 -1.078 1.00 32.54 ? 28 TYR A CE1 1 ATOM 92 C CE2 . TYR A 1 11 ? 2.778 -25.594 -0.476 1.00 32.28 ? 28 TYR A CE2 1 ATOM 93 C CZ . TYR A 1 11 ? 1.562 -25.972 -1.009 1.00 33.74 ? 28 TYR A CZ 1 ATOM 94 O OH . TYR A 1 11 ? 0.708 -25.001 -1.472 1.00 37.88 ? 28 TYR A OH 1 ATOM 95 N N . LEU A 1 12 ? 6.752 -27.601 -0.938 1.00 24.66 ? 29 LEU A N 1 ATOM 96 C CA . LEU A 1 12 ? 7.389 -26.520 -1.707 1.00 24.36 ? 29 LEU A CA 1 ATOM 97 C C . LEU A 1 12 ? 8.188 -27.020 -2.897 1.00 23.97 ? 29 LEU A C 1 ATOM 98 O O . LEU A 1 12 ? 8.147 -26.403 -3.963 1.00 22.97 ? 29 LEU A O 1 ATOM 99 C CB . LEU A 1 12 ? 8.299 -25.662 -0.814 1.00 24.24 ? 29 LEU A CB 1 ATOM 100 C CG . LEU A 1 12 ? 7.583 -24.735 0.162 1.00 24.51 ? 29 LEU A CG 1 ATOM 101 C CD1 . LEU A 1 12 ? 8.580 -24.145 1.157 1.00 24.19 ? 29 LEU A CD1 1 ATOM 102 C CD2 . LEU A 1 12 ? 6.840 -23.640 -0.597 1.00 25.10 ? 29 LEU A CD2 1 ATOM 103 N N . GLU A 1 13 ? 8.921 -28.119 -2.730 1.00 25.07 ? 30 GLU A N 1 ATOM 104 C CA . GLU A 1 13 ? 9.681 -28.685 -3.845 1.00 27.57 ? 30 GLU A CA 1 ATOM 105 C C . GLU A 1 13 ? 8.755 -29.041 -5.010 1.00 26.60 ? 30 GLU A C 1 ATOM 106 O O . GLU A 1 13 ? 9.045 -28.715 -6.164 1.00 25.46 ? 30 GLU A O 1 ATOM 107 C CB . GLU A 1 13 ? 10.490 -29.909 -3.411 1.00 30.33 ? 30 GLU A CB 1 ATOM 108 C CG . GLU A 1 13 ? 11.443 -30.407 -4.487 1.00 34.33 ? 30 GLU A CG 1 ATOM 109 C CD . GLU A 1 13 ? 12.319 -31.565 -4.039 1.00 39.43 ? 30 GLU A CD 1 ATOM 110 O OE1 . GLU A 1 13 ? 12.453 -31.796 -2.813 1.00 42.42 ? 30 GLU A OE1 1 ATOM 111 O OE2 . GLU A 1 13 ? 12.878 -32.246 -4.929 1.00 43.60 ? 30 GLU A OE2 1 ATOM 112 N N . ASN A 1 14 ? 7.636 -29.691 -4.703 1.00 26.08 ? 31 ASN A N 1 ATOM 113 C CA . ASN A 1 14 ? 6.660 -30.050 -5.736 1.00 26.73 ? 31 ASN A CA 1 ATOM 114 C C . ASN A 1 14 ? 5.936 -28.843 -6.318 1.00 25.18 ? 31 ASN A C 1 ATOM 115 O O . ASN A 1 14 ? 5.753 -28.768 -7.528 1.00 23.70 ? 31 ASN A O 1 ATOM 116 C CB . ASN A 1 14 ? 5.670 -31.093 -5.214 1.00 28.06 ? 31 ASN A CB 1 ATOM 117 C CG . ASN A 1 14 ? 6.341 -32.428 -4.942 1.00 30.25 ? 31 ASN A CG 1 ATOM 118 O OD1 . ASN A 1 14 ? 7.254 -32.830 -5.666 1.00 32.42 ? 31 ASN A OD1 1 ATOM 119 N ND2 . ASN A 1 14 ? 5.902 -33.121 -3.892 1.00 32.24 ? 31 ASN A ND2 1 ATOM 120 N N . LEU A 1 15 ? 5.565 -27.889 -5.467 1.00 23.82 ? 32 LEU A N 1 ATOM 121 C CA . LEU A 1 15 ? 4.926 -26.667 -5.930 1.00 24.24 ? 32 LEU A CA 1 ATOM 122 C C . LEU A 1 15 ? 5.830 -25.858 -6.870 1.00 22.70 ? 32 LEU A C 1 ATOM 123 O O . LEU A 1 15 ? 5.382 -25.407 -7.927 1.00 22.96 ? 32 LEU A O 1 ATOM 124 C CB . LEU A 1 15 ? 4.496 -25.796 -4.751 1.00 25.32 ? 32 LEU A CB 1 ATOM 125 C CG . LEU A 1 15 ? 3.913 -24.432 -5.099 1.00 25.83 ? 32 LEU A CG 1 ATOM 126 C CD1 . LEU A 1 15 ? 2.714 -24.575 -6.029 1.00 27.31 ? 32 LEU A CD1 1 ATOM 127 C CD2 . LEU A 1 15 ? 3.529 -23.699 -3.829 1.00 26.84 ? 32 LEU A CD2 1 ATOM 128 N N . ASN A 1 16 ? 7.087 -25.673 -6.476 1.00 21.66 ? 33 ASN A N 1 ATOM 129 C CA . ASN A 1 16 ? 8.059 -24.975 -7.327 1.00 21.34 ? 33 ASN A CA 1 ATOM 130 C C . ASN A 1 16 ? 8.217 -25.635 -8.692 1.00 21.64 ? 33 ASN A C 1 ATOM 131 O O . ASN A 1 16 ? 8.240 -24.949 -9.715 1.00 19.70 ? 33 ASN A O 1 ATOM 132 C CB . ASN A 1 16 ? 9.414 -24.849 -6.626 1.00 20.68 ? 33 ASN A CB 1 ATOM 133 C CG . ASN A 1 16 ? 9.469 -23.647 -5.689 1.00 21.14 ? 33 ASN A CG 1 ATOM 134 O OD1 . ASN A 1 16 ? 9.410 -22.490 -6.135 1.00 20.57 ? 33 ASN A OD1 1 ATOM 135 N ND2 . ASN A 1 16 ? 9.567 -23.908 -4.390 1.00 20.55 ? 33 ASN A ND2 1 ATOM 136 N N . LYS A 1 17 ? 8.295 -26.966 -8.706 1.00 23.00 ? 34 LYS A N 1 ATOM 137 C CA . LYS A 1 17 ? 8.345 -27.718 -9.969 1.00 24.92 ? 34 LYS A CA 1 ATOM 138 C C . LYS A 1 17 ? 7.125 -27.444 -10.841 1.00 23.62 ? 34 LYS A C 1 ATOM 139 O O . LYS A 1 17 ? 7.255 -27.213 -12.043 1.00 22.95 ? 34 LYS A O 1 ATOM 140 C CB . LYS A 1 17 ? 8.477 -29.231 -9.736 1.00 28.22 ? 34 LYS A CB 1 ATOM 141 C CG . LYS A 1 17 ? 9.915 -29.714 -9.653 1.00 33.29 ? 34 LYS A CG 1 ATOM 142 C CD . LYS A 1 17 ? 10.025 -31.236 -9.777 1.00 37.04 ? 34 LYS A CD 1 ATOM 143 C CE . LYS A 1 17 ? 9.986 -31.922 -8.422 1.00 40.06 ? 34 LYS A CE 1 ATOM 144 N NZ . LYS A 1 17 ? 11.336 -31.935 -7.791 1.00 42.63 ? 34 LYS A NZ 1 ATOM 145 N N . GLU A 1 18 ? 5.947 -27.465 -10.234 1.00 22.98 ? 35 GLU A N 1 ATOM 146 C CA . GLU A 1 18 ? 4.705 -27.240 -10.973 1.00 23.56 ? 35 GLU A CA 1 ATOM 147 C C . GLU A 1 18 ? 4.603 -25.802 -11.475 1.00 23.18 ? 35 GLU A C 1 ATOM 148 O O . GLU A 1 18 ? 4.154 -25.568 -12.597 1.00 21.76 ? 35 GLU A O 1 ATOM 149 C CB . GLU A 1 18 ? 3.495 -27.599 -10.110 1.00 24.86 ? 35 GLU A CB 1 ATOM 150 C CG . GLU A 1 18 ? 2.140 -27.505 -10.802 1.00 26.36 ? 35 GLU A CG 1 ATOM 151 C CD . GLU A 1 18 ? 1.985 -28.433 -12.009 1.00 27.81 ? 35 GLU A CD 1 ATOM 152 O OE1 . GLU A 1 18 ? 2.717 -29.437 -12.134 1.00 27.86 ? 35 GLU A OE1 1 ATOM 153 O OE2 . GLU A 1 18 ? 1.100 -28.142 -12.841 1.00 29.56 ? 35 GLU A OE2 1 ATOM 154 N N . LEU A 1 19 ? 5.020 -24.840 -10.651 1.00 22.40 ? 36 LEU A N 1 ATOM 155 C CA . LEU A 1 19 ? 5.044 -23.439 -11.085 1.00 22.59 ? 36 LEU A CA 1 ATOM 156 C C . LEU A 1 19 ? 5.973 -23.222 -12.269 1.00 21.47 ? 36 LEU A C 1 ATOM 157 O O . LEU A 1 19 ? 5.626 -22.489 -13.191 1.00 21.47 ? 36 LEU A O 1 ATOM 158 C CB . LEU A 1 19 ? 5.434 -22.506 -9.932 1.00 23.43 ? 36 LEU A CB 1 ATOM 159 C CG . LEU A 1 19 ? 4.389 -22.304 -8.843 1.00 24.48 ? 36 LEU A CG 1 ATOM 160 C CD1 . LEU A 1 19 ? 5.011 -21.572 -7.664 1.00 25.17 ? 36 LEU A CD1 1 ATOM 161 C CD2 . LEU A 1 19 ? 3.192 -21.527 -9.356 1.00 25.45 ? 36 LEU A CD2 1 ATOM 162 N N . ALA A 1 20 ? 7.146 -23.851 -12.249 1.00 21.54 ? 37 ALA A N 1 ATOM 163 C CA . ALA A 1 20 ? 8.086 -23.765 -13.363 1.00 21.58 ? 37 ALA A CA 1 ATOM 164 C C . ALA A 1 20 ? 7.480 -24.356 -14.642 1.00 21.96 ? 37 ALA A C 1 ATOM 165 O O . ALA A 1 20 ? 7.597 -23.776 -15.725 1.00 20.81 ? 37 ALA A O 1 ATOM 166 C CB . ALA A 1 20 ? 9.382 -24.475 -13.025 1.00 22.28 ? 37 ALA A CB 1 ATOM 167 N N . LYS A 1 21 ? 6.815 -25.499 -14.496 1.00 22.26 ? 38 LYS A N 1 ATOM 168 C CA . LYS A 1 21 ? 6.154 -26.174 -15.622 1.00 22.27 ? 38 LYS A CA 1 ATOM 169 C C . LYS A 1 21 ? 5.068 -25.303 -16.264 1.00 21.81 ? 38 LYS A C 1 ATOM 170 O O . LYS A 1 21 ? 5.026 -25.133 -17.493 1.00 23.02 ? 38 LYS A O 1 ATOM 171 C CB . LYS A 1 21 ? 5.564 -27.504 -15.138 1.00 23.43 ? 38 LYS A CB 1 ATOM 172 C CG . LYS A 1 21 ? 4.972 -28.390 -16.226 1.00 23.96 ? 38 LYS A CG 1 ATOM 173 C CD . LYS A 1 21 ? 4.506 -29.719 -15.643 1.00 24.45 ? 38 LYS A CD 1 ATOM 174 C CE . LYS A 1 21 ? 3.749 -30.525 -16.684 1.00 25.20 ? 38 LYS A CE 1 ATOM 175 N NZ . LYS A 1 21 ? 3.286 -31.833 -16.143 1.00 26.27 ? 38 LYS A NZ 1 ATOM 176 N N . ARG A 1 22 ? 4.204 -24.731 -15.439 1.00 21.65 ? 39 ARG A N 1 ATOM 177 C CA . ARG A 1 22 ? 3.132 -23.869 -15.932 1.00 22.03 ? 39 ARG A CA 1 ATOM 178 C C . ARG A 1 22 ? 3.654 -22.524 -16.461 1.00 21.25 ? 39 ARG A C 1 ATOM 179 O O . ARG A 1 22 ? 3.174 -22.015 -17.470 1.00 19.96 ? 39 ARG A O 1 ATOM 180 C CB . ARG A 1 22 ? 2.085 -23.634 -14.857 1.00 23.40 ? 39 ARG A CB 1 ATOM 181 C CG . ARG A 1 22 ? 1.300 -24.885 -14.488 1.00 25.13 ? 39 ARG A CG 1 ATOM 182 C CD . ARG A 1 22 ? 0.405 -24.584 -13.305 1.00 27.01 ? 39 ARG A CD 1 ATOM 183 N NE . ARG A 1 22 ? -0.366 -25.750 -12.855 1.00 28.01 ? 39 ARG A NE 1 ATOM 184 C CZ . ARG A 1 22 ? -1.694 -25.816 -12.733 1.00 27.94 ? 39 ARG A CZ 1 ATOM 185 N NH1 . ARG A 1 22 ? -2.485 -24.796 -13.044 1.00 30.14 ? 39 ARG A NH1 1 ATOM 186 N NH2 . ARG A 1 22 ? -2.241 -26.941 -12.294 1.00 28.78 ? 39 ARG A NH2 1 ATOM 187 N N . THR A 1 23 ? 4.634 -21.954 -15.776 1.00 20.27 ? 40 THR A N 1 ATOM 188 C CA . THR A 1 23 ? 5.236 -20.702 -16.230 1.00 20.38 ? 40 THR A CA 1 ATOM 189 C C . THR A 1 23 ? 5.981 -20.883 -17.561 1.00 20.01 ? 40 THR A C 1 ATOM 190 O O . THR A 1 23 ? 5.973 -19.974 -18.394 1.00 20.18 ? 40 THR A O 1 ATOM 191 C CB . THR A 1 23 ? 6.115 -20.101 -15.128 1.00 19.85 ? 40 THR A CB 1 ATOM 192 O OG1 . THR A 1 23 ? 5.296 -19.904 -13.970 1.00 18.04 ? 40 THR A OG1 1 ATOM 193 C CG2 . THR A 1 23 ? 6.711 -18.764 -15.552 1.00 20.12 ? 40 THR A CG2 1 ATOM 194 N N . ASN A 1 24 ? 6.584 -22.056 -17.776 1.00 19.62 ? 41 ASN A N 1 ATOM 195 C CA . ASN A 1 24 ? 7.182 -22.390 -19.071 1.00 19.98 ? 41 ASN A CA 1 ATOM 196 C C . ASN A 1 24 ? 6.198 -22.179 -20.228 1.00 20.48 ? 41 ASN A C 1 ATOM 197 O O . ASN A 1 24 ? 6.545 -21.558 -21.248 1.00 20.25 ? 41 ASN A O 1 ATOM 198 C CB . ASN A 1 24 ? 7.698 -23.836 -19.078 1.00 19.99 ? 41 ASN A CB 1 ATOM 199 C CG . ASN A 1 24 ? 7.988 -24.347 -20.476 1.00 20.78 ? 41 ASN A CG 1 ATOM 200 O OD1 . ASN A 1 24 ? 7.174 -25.067 -21.069 1.00 21.34 ? 41 ASN A OD1 1 ATOM 201 N ND2 . ASN A 1 24 ? 9.131 -23.957 -21.024 1.00 20.12 ? 41 ASN A ND2 1 ATOM 202 N N . VAL A 1 25 ? 4.970 -22.660 -20.060 1.00 20.57 ? 42 VAL A N 1 ATOM 203 C CA . VAL A 1 25 ? 3.976 -22.567 -21.137 1.00 21.57 ? 42 VAL A CA 1 ATOM 204 C C . VAL A 1 25 ? 3.468 -21.130 -21.279 1.00 21.80 ? 42 VAL A C 1 ATOM 205 O O . VAL A 1 25 ? 3.303 -20.658 -22.400 1.00 21.33 ? 42 VAL A O 1 ATOM 206 C CB . VAL A 1 25 ? 2.790 -23.538 -20.961 1.00 22.57 ? 42 VAL A CB 1 ATOM 207 C CG1 . VAL A 1 25 ? 1.961 -23.587 -22.240 1.00 22.89 ? 42 VAL A CG1 1 ATOM 208 C CG2 . VAL A 1 25 ? 3.285 -24.946 -20.635 1.00 22.79 ? 42 VAL A CG2 1 ATOM 209 N N . GLU A 1 26 ? 3.222 -20.447 -20.159 1.00 21.66 ? 43 GLU A N 1 ATOM 210 C CA . GLU A 1 26 ? 2.906 -19.010 -20.182 1.00 22.89 ? 43 GLU A CA 1 ATOM 211 C C . GLU A 1 26 ? 3.964 -18.239 -20.981 1.00 21.83 ? 43 GLU A C 1 ATOM 212 O O . GLU A 1 26 ? 3.631 -17.390 -21.816 1.00 21.02 ? 43 GLU A O 1 ATOM 213 C CB . GLU A 1 26 ? 2.803 -18.434 -18.759 1.00 24.96 ? 43 GLU A CB 1 ATOM 214 C CG . GLU A 1 26 ? 2.280 -16.990 -18.714 1.00 27.87 ? 43 GLU A CG 1 ATOM 215 C CD . GLU A 1 26 ? 2.457 -16.302 -17.363 1.00 31.68 ? 43 GLU A CD 1 ATOM 216 O OE1 . GLU A 1 26 ? 3.525 -16.475 -16.718 1.00 32.25 ? 43 GLU A OE1 1 ATOM 217 O OE2 . GLU A 1 26 ? 1.527 -15.570 -16.941 1.00 33.78 ? 43 GLU A OE2 1 ATOM 218 N N . THR A 1 27 ? 5.229 -18.561 -20.721 1.00 21.89 ? 44 THR A N 1 ATOM 219 C CA . THR A 1 27 ? 6.354 -17.942 -21.396 1.00 21.94 ? 44 THR A CA 1 ATOM 220 C C . THR A 1 27 ? 6.399 -18.263 -22.896 1.00 22.50 ? 44 THR A C 1 ATOM 221 O O . THR A 1 27 ? 6.697 -17.378 -23.698 1.00 21.49 ? 44 THR A O 1 ATOM 222 C CB . THR A 1 27 ? 7.683 -18.305 -20.692 1.00 22.75 ? 44 THR A CB 1 ATOM 223 O OG1 . THR A 1 27 ? 7.575 -17.969 -19.304 1.00 22.36 ? 44 THR A OG1 1 ATOM 224 C CG2 . THR A 1 27 ? 8.852 -17.539 -21.281 1.00 22.67 ? 44 THR A CG2 1 ATOM 225 N N . GLU A 1 28 ? 6.093 -19.506 -23.284 1.00 22.61 ? 45 GLU A N 1 ATOM 226 C CA . GLU A 1 28 ? 5.941 -19.848 -24.707 1.00 24.06 ? 45 GLU A CA 1 ATOM 227 C C . GLU A 1 28 ? 4.883 -18.996 -25.398 1.00 22.77 ? 45 GLU A C 1 ATOM 228 O O . GLU A 1 28 ? 5.125 -18.472 -26.495 1.00 22.12 ? 45 GLU A O 1 ATOM 229 C CB . GLU A 1 28 ? 5.592 -21.335 -24.905 1.00 26.12 ? 45 GLU A CB 1 ATOM 230 C CG . GLU A 1 28 ? 6.756 -22.285 -24.664 1.00 29.41 ? 45 GLU A CG 1 ATOM 231 C CD . GLU A 1 28 ? 7.789 -22.281 -25.777 1.00 31.73 ? 45 GLU A CD 1 ATOM 232 O OE1 . GLU A 1 28 ? 7.591 -21.582 -26.800 1.00 35.67 ? 45 GLU A OE1 1 ATOM 233 O OE2 . GLU A 1 28 ? 8.809 -22.988 -25.630 1.00 34.05 ? 45 GLU A OE2 1 ATOM 234 N N . ALA A 1 29 ? 3.720 -18.864 -24.761 1.00 21.60 ? 46 ALA A N 1 ATOM 235 C CA . ALA A 1 29 ? 2.629 -18.049 -25.300 1.00 21.56 ? 46 ALA A CA 1 ATOM 236 C C . ALA A 1 29 ? 3.009 -16.574 -25.413 1.00 22.24 ? 46 ALA A C 1 ATOM 237 O O . ALA A 1 29 ? 2.730 -15.931 -26.438 1.00 21.41 ? 46 ALA A O 1 ATOM 238 C CB . ALA A 1 29 ? 1.366 -18.204 -24.467 1.00 22.00 ? 46 ALA A CB 1 ATOM 239 N N . ALA A 1 30 ? 3.662 -16.046 -24.381 1.00 21.94 ? 47 ALA A N 1 ATOM 240 C CA . ALA A 1 30 ? 4.140 -14.653 -24.424 1.00 22.72 ? 47 ALA A CA 1 ATOM 241 C C . ALA A 1 30 ? 5.187 -14.439 -25.517 1.00 22.53 ? 47 ALA A C 1 ATOM 242 O O . ALA A 1 30 ? 5.147 -13.418 -26.207 1.00 22.39 ? 47 ALA A O 1 ATOM 243 C CB . ALA A 1 30 ? 4.681 -14.212 -23.071 1.00 22.94 ? 47 ALA A CB 1 ATOM 244 N N . TRP A 1 31 ? 6.096 -15.405 -25.676 1.00 21.74 ? 48 TRP A N 1 ATOM 245 C CA . TRP A 1 31 ? 7.097 -15.386 -26.746 1.00 22.15 ? 48 TRP A CA 1 ATOM 246 C C . TRP A 1 31 ? 6.457 -15.396 -28.144 1.00 23.44 ? 48 TRP A C 1 ATOM 247 O O . TRP A 1 31 ? 6.841 -14.599 -29.011 1.00 23.70 ? 48 TRP A O 1 ATOM 248 C CB . TRP A 1 31 ? 8.072 -16.555 -26.574 1.00 22.53 ? 48 TRP A CB 1 ATOM 249 C CG . TRP A 1 31 ? 8.992 -16.817 -27.723 1.00 22.26 ? 48 TRP A CG 1 ATOM 250 C CD1 . TRP A 1 31 ? 8.772 -17.652 -28.778 1.00 23.41 ? 48 TRP A CD1 1 ATOM 251 C CD2 . TRP A 1 31 ? 10.301 -16.279 -27.904 1.00 22.74 ? 48 TRP A CD2 1 ATOM 252 N NE1 . TRP A 1 31 ? 9.858 -17.647 -29.621 1.00 23.77 ? 48 TRP A NE1 1 ATOM 253 C CE2 . TRP A 1 31 ? 10.813 -16.813 -29.106 1.00 22.87 ? 48 TRP A CE2 1 ATOM 254 C CE3 . TRP A 1 31 ? 11.087 -15.375 -27.175 1.00 22.49 ? 48 TRP A CE3 1 ATOM 255 C CZ2 . TRP A 1 31 ? 12.078 -16.478 -29.596 1.00 23.14 ? 48 TRP A CZ2 1 ATOM 256 C CZ3 . TRP A 1 31 ? 12.351 -15.044 -27.665 1.00 22.68 ? 48 TRP A CZ3 1 ATOM 257 C CH2 . TRP A 1 31 ? 12.829 -15.592 -28.864 1.00 23.01 ? 48 TRP A CH2 1 ATOM 258 N N . ALA A 1 32 ? 5.493 -16.289 -28.362 1.00 22.66 ? 49 ALA A N 1 ATOM 259 C CA . ALA A 1 32 ? 4.759 -16.331 -29.633 1.00 23.28 ? 49 ALA A CA 1 ATOM 260 C C . ALA A 1 32 ? 4.135 -14.978 -29.990 1.00 23.39 ? 49 ALA A C 1 ATOM 261 O O . ALA A 1 32 ? 4.285 -14.492 -31.115 1.00 24.50 ? 49 ALA A O 1 ATOM 262 C CB . ALA A 1 32 ? 3.687 -17.411 -29.592 1.00 23.08 ? 49 ALA A CB 1 ATOM 263 N N . TYR A 1 33 ? 3.462 -14.369 -29.021 1.00 23.70 ? 50 TYR A N 1 ATOM 264 C CA . TYR A 1 33 ? 2.778 -13.098 -29.223 1.00 24.69 ? 50 TYR A CA 1 ATOM 265 C C . TYR A 1 33 ? 3.764 -11.972 -29.505 1.00 25.37 ? 50 TYR A C 1 ATOM 266 O O . TYR A 1 33 ? 3.547 -11.174 -30.424 1.00 24.56 ? 50 TYR A O 1 ATOM 267 C CB . TYR A 1 33 ? 1.933 -12.743 -28.004 1.00 25.69 ? 50 TYR A CB 1 ATOM 268 C CG . TYR A 1 33 ? 1.175 -11.438 -28.144 1.00 27.83 ? 50 TYR A CG 1 ATOM 269 C CD1 . TYR A 1 33 ? 0.229 -11.273 -29.155 1.00 28.54 ? 50 TYR A CD1 1 ATOM 270 C CD2 . TYR A 1 33 ? 1.403 -10.365 -27.269 1.00 29.83 ? 50 TYR A CD2 1 ATOM 271 C CE1 . TYR A 1 33 ? -0.471 -10.089 -29.297 1.00 29.89 ? 50 TYR A CE1 1 ATOM 272 C CE2 . TYR A 1 33 ? 0.697 -9.172 -27.398 1.00 30.63 ? 50 TYR A CE2 1 ATOM 273 C CZ . TYR A 1 33 ? -0.235 -9.039 -28.416 1.00 31.50 ? 50 TYR A CZ 1 ATOM 274 O OH . TYR A 1 33 ? -0.953 -7.871 -28.564 1.00 34.54 ? 50 TYR A OH 1 ATOM 275 N N . GLY A 1 34 ? 4.839 -11.927 -28.717 1.00 25.84 ? 51 GLY A N 1 ATOM 276 C CA . GLY A 1 34 ? 5.883 -10.917 -28.856 1.00 26.50 ? 51 GLY A CA 1 ATOM 277 C C . GLY A 1 34 ? 6.685 -11.026 -30.138 1.00 26.27 ? 51 GLY A C 1 ATOM 278 O O . GLY A 1 34 ? 7.195 -10.022 -30.627 1.00 26.83 ? 51 GLY A O 1 ATOM 279 N N . SER A 1 35 ? 6.813 -12.236 -30.679 1.00 26.52 ? 52 SER A N 1 ATOM 280 C CA . SER A 1 35 ? 7.518 -12.447 -31.939 1.00 27.22 ? 52 SER A CA 1 ATOM 281 C C . SER A 1 35 ? 6.584 -12.451 -33.156 1.00 26.79 ? 52 SER A C 1 ATOM 282 O O . SER A 1 35 ? 7.057 -12.512 -34.287 1.00 25.68 ? 52 SER A O 1 ATOM 283 C CB . SER A 1 35 ? 8.342 -13.738 -31.879 1.00 28.34 ? 52 SER A CB 1 ATOM 284 O OG . SER A 1 35 ? 7.513 -14.861 -31.703 1.00 31.15 ? 52 SER A OG 1 ATOM 285 N N . ASN A 1 36 ? 5.276 -12.366 -32.919 1.00 26.83 ? 53 ASN A N 1 ATOM 286 C CA . ASN A 1 36 ? 4.272 -12.413 -33.977 1.00 28.09 ? 53 ASN A CA 1 ATOM 287 C C . ASN A 1 36 ? 2.912 -11.985 -33.401 1.00 27.17 ? 53 ASN A C 1 ATOM 288 O O . ASN A 1 36 ? 2.139 -12.801 -32.886 1.00 26.17 ? 53 ASN A O 1 ATOM 289 C CB . ASN A 1 36 ? 4.245 -13.828 -34.567 1.00 31.23 ? 53 ASN A CB 1 ATOM 290 C CG . ASN A 1 36 ? 3.220 -14.011 -35.670 1.00 35.26 ? 53 ASN A CG 1 ATOM 291 O OD1 . ASN A 1 36 ? 2.776 -13.061 -36.315 1.00 33.13 ? 53 ASN A OD1 1 ATOM 292 N ND2 . ASN A 1 36 ? 2.844 -15.269 -35.885 1.00 42.11 ? 53 ASN A ND2 1 ATOM 293 N N . ILE A 1 37 ? 2.647 -10.688 -33.477 1.00 25.76 ? 54 ILE A N 1 ATOM 294 C CA . ILE A 1 37 ? 1.466 -10.083 -32.875 1.00 26.24 ? 54 ILE A CA 1 ATOM 295 C C . ILE A 1 37 ? 0.241 -10.421 -33.715 1.00 27.11 ? 54 ILE A C 1 ATOM 296 O O . ILE A 1 37 ? 0.129 -9.980 -34.856 1.00 29.40 ? 54 ILE A O 1 ATOM 297 C CB . ILE A 1 37 ? 1.634 -8.553 -32.730 1.00 26.66 ? 54 ILE A CB 1 ATOM 298 C CG1 . ILE A 1 37 ? 2.775 -8.269 -31.751 1.00 26.86 ? 54 ILE A CG1 1 ATOM 299 C CG2 . ILE A 1 37 ? 0.340 -7.886 -32.241 1.00 26.77 ? 54 ILE A CG2 1 ATOM 300 C CD1 . ILE A 1 37 ? 3.273 -6.851 -31.782 1.00 28.43 ? 54 ILE A CD1 1 ATOM 301 N N . THR A 1 38 ? -0.641 -11.246 -33.158 1.00 25.95 ? 55 THR A N 1 ATOM 302 C CA . THR A 1 38 ? -1.911 -11.611 -33.793 1.00 24.87 ? 55 THR A CA 1 ATOM 303 C C . THR A 1 38 ? -2.964 -11.698 -32.706 1.00 25.05 ? 55 THR A C 1 ATOM 304 O O . THR A 1 38 ? -2.640 -11.911 -31.531 1.00 23.12 ? 55 THR A O 1 ATOM 305 C CB . THR A 1 38 ? -1.848 -12.968 -34.542 1.00 24.94 ? 55 THR A CB 1 ATOM 306 O OG1 . THR A 1 38 ? -1.631 -14.045 -33.617 1.00 23.49 ? 55 THR A OG1 1 ATOM 307 C CG2 . THR A 1 38 ? -0.741 -12.987 -35.570 1.00 25.37 ? 55 THR A CG2 1 ATOM 308 N N . ASP A 1 39 ? -4.225 -11.538 -33.092 1.00 25.23 ? 56 ASP A N 1 ATOM 309 C CA . ASP A 1 39 ? -5.323 -11.651 -32.139 1.00 27.09 ? 56 ASP A CA 1 ATOM 310 C C . ASP A 1 39 ? -5.341 -13.041 -31.502 1.00 26.53 ? 56 ASP A C 1 ATOM 311 O O . ASP A 1 39 ? -5.589 -13.175 -30.304 1.00 25.86 ? 56 ASP A O 1 ATOM 312 C CB . ASP A 1 39 ? -6.677 -11.356 -32.805 1.00 29.88 ? 56 ASP A CB 1 ATOM 313 C CG . ASP A 1 39 ? -6.849 -9.886 -33.175 1.00 32.81 ? 56 ASP A CG 1 ATOM 314 O OD1 . ASP A 1 39 ? -6.073 -9.024 -32.700 1.00 35.92 ? 56 ASP A OD1 1 ATOM 315 O OD2 . ASP A 1 39 ? -7.785 -9.585 -33.938 1.00 37.25 ? 56 ASP A OD2 1 ATOM 316 N N . GLU A 1 40 ? -5.050 -14.053 -32.315 1.00 25.79 ? 57 GLU A N 1 ATOM 317 C CA . GLU A 1 40 ? -4.975 -15.445 -31.871 1.00 28.40 ? 57 GLU A CA 1 ATOM 318 C C . GLU A 1 40 ? -3.868 -15.670 -30.838 1.00 25.86 ? 57 GLU A C 1 ATOM 319 O O . GLU A 1 40 ? -4.098 -16.302 -29.796 1.00 23.73 ? 57 GLU A O 1 ATOM 320 C CB . GLU A 1 40 ? -4.760 -16.328 -33.093 1.00 32.87 ? 57 GLU A CB 1 ATOM 321 C CG . GLU A 1 40 ? -4.689 -17.812 -32.843 1.00 38.60 ? 57 GLU A CG 1 ATOM 322 C CD . GLU A 1 40 ? -4.772 -18.595 -34.141 1.00 43.23 ? 57 GLU A CD 1 ATOM 323 O OE1 . GLU A 1 40 ? -5.860 -18.595 -34.766 1.00 48.63 ? 57 GLU A OE1 1 ATOM 324 O OE2 . GLU A 1 40 ? -3.751 -19.205 -34.532 1.00 47.36 ? 57 GLU A OE2 1 ATOM 325 N N . ASN A 1 41 ? -2.678 -15.143 -31.116 1.00 23.16 ? 58 ASN A N 1 ATOM 326 C CA . ASN A 1 41 ? -1.581 -15.231 -30.153 1.00 23.46 ? 58 ASN A CA 1 ATOM 327 C C . ASN A 1 41 ? -1.846 -14.429 -28.881 1.00 23.29 ? 58 ASN A C 1 ATOM 328 O O . ASN A 1 41 ? -1.506 -14.890 -27.789 1.00 23.22 ? 58 ASN A O 1 ATOM 329 C CB . ASN A 1 41 ? -0.236 -14.844 -30.788 1.00 22.88 ? 58 ASN A CB 1 ATOM 330 C CG . ASN A 1 41 ? 0.318 -15.929 -31.696 1.00 23.54 ? 58 ASN A CG 1 ATOM 331 O OD1 . ASN A 1 41 ? -0.121 -17.084 -31.652 1.00 23.65 ? 58 ASN A OD1 1 ATOM 332 N ND2 . ASN A 1 41 ? 1.289 -15.566 -32.531 1.00 22.50 ? 58 ASN A ND2 1 ATOM 333 N N . GLU A 1 42 ? -2.471 -13.254 -29.009 1.00 23.92 ? 59 GLU A N 1 ATOM 334 C CA . GLU A 1 42 ? -2.886 -12.480 -27.838 1.00 25.09 ? 59 GLU A CA 1 ATOM 335 C C . GLU A 1 42 ? -3.832 -13.270 -26.926 1.00 24.65 ? 59 GLU A C 1 ATOM 336 O O . GLU A 1 42 ? -3.645 -13.296 -25.706 1.00 22.46 ? 59 GLU A O 1 ATOM 337 C CB . GLU A 1 42 ? -3.588 -11.173 -28.229 1.00 27.60 ? 59 GLU A CB 1 ATOM 338 C CG . GLU A 1 42 ? -3.760 -10.223 -27.045 1.00 29.97 ? 59 GLU A CG 1 ATOM 339 C CD . GLU A 1 42 ? -4.855 -9.193 -27.240 1.00 33.96 ? 59 GLU A CD 1 ATOM 340 O OE1 . GLU A 1 42 ? -4.948 -8.633 -28.353 1.00 35.80 ? 59 GLU A OE1 1 ATOM 341 O OE2 . GLU A 1 42 ? -5.610 -8.935 -26.267 1.00 36.30 ? 59 GLU A OE2 1 ATOM 342 N N . LYS A 1 43 ? -4.857 -13.878 -27.523 1.00 24.90 ? 60 LYS A N 1 ATOM 343 C CA . LYS A 1 43 ? -5.867 -14.619 -26.763 1.00 26.27 ? 60 LYS A CA 1 ATOM 344 C C . LYS A 1 43 ? -5.277 -15.815 -26.007 1.00 24.41 ? 60 LYS A C 1 ATOM 345 O O . LYS A 1 43 ? -5.655 -16.057 -24.865 1.00 24.11 ? 60 LYS A O 1 ATOM 346 C CB . LYS A 1 43 ? -7.008 -15.077 -27.673 1.00 29.15 ? 60 LYS A CB 1 ATOM 347 C CG . LYS A 1 43 ? -7.922 -13.953 -28.162 1.00 32.71 ? 60 LYS A CG 1 ATOM 348 C CD . LYS A 1 43 ? -8.973 -14.507 -29.130 1.00 36.10 ? 60 LYS A CD 1 ATOM 349 C CE . LYS A 1 43 ? -9.316 -13.559 -30.276 1.00 39.52 ? 60 LYS A CE 1 ATOM 350 N NZ . LYS A 1 43 ? -10.346 -12.553 -29.897 1.00 40.14 ? 60 LYS A NZ 1 ATOM 351 N N . LYS A 1 44 ? -4.359 -16.552 -26.636 1.00 23.13 ? 61 LYS A N 1 ATOM 352 C CA . LYS A 1 44 ? -3.680 -17.672 -25.956 1.00 22.99 ? 61 LYS A CA 1 ATOM 353 C C . LYS A 1 44 ? -2.803 -17.203 -24.802 1.00 21.78 ? 61 LYS A C 1 ATOM 354 O O . LYS A 1 44 ? -2.841 -17.786 -23.734 1.00 20.17 ? 61 LYS A O 1 ATOM 355 C CB . LYS A 1 44 ? -2.857 -18.503 -26.927 1.00 24.51 ? 61 LYS A CB 1 ATOM 356 C CG . LYS A 1 44 ? -3.737 -19.253 -27.911 1.00 26.36 ? 61 LYS A CG 1 ATOM 357 C CD . LYS A 1 44 ? -2.926 -20.104 -28.856 1.00 27.31 ? 61 LYS A CD 1 ATOM 358 C CE . LYS A 1 44 ? -3.806 -20.583 -29.993 1.00 28.04 ? 61 LYS A CE 1 ATOM 359 N NZ . LYS A 1 44 ? -3.014 -21.444 -30.897 1.00 29.17 ? 61 LYS A NZ 1 ATOM 360 N N . LYS A 1 45 ? -2.022 -16.149 -25.029 1.00 21.02 ? 62 LYS A N 1 ATOM 361 C CA . LYS A 1 45 ? -1.197 -15.547 -23.968 1.00 22.73 ? 62 LYS A CA 1 ATOM 362 C C . LYS A 1 45 ? -2.041 -15.131 -22.775 1.00 21.65 ? 62 LYS A C 1 ATOM 363 O O . LYS A 1 45 ? -1.692 -15.412 -21.631 1.00 22.46 ? 62 LYS A O 1 ATOM 364 C CB . LYS A 1 45 ? -0.435 -14.319 -24.502 1.00 24.23 ? 62 LYS A CB 1 ATOM 365 C CG . LYS A 1 45 ? 0.414 -13.605 -23.460 1.00 26.86 ? 62 LYS A CG 1 ATOM 366 C CD . LYS A 1 45 ? 0.972 -12.288 -23.987 1.00 29.31 ? 62 LYS A CD 1 ATOM 367 C CE . LYS A 1 45 ? 1.606 -11.495 -22.853 1.00 31.86 ? 62 LYS A CE 1 ATOM 368 N NZ . LYS A 1 45 ? 2.489 -10.412 -23.363 1.00 33.82 ? 62 LYS A NZ 1 ATOM 369 N N . ASN A 1 46 ? -3.141 -14.444 -23.042 1.00 21.10 ? 63 ASN A N 1 ATOM 370 C CA . ASN A 1 46 ? -3.983 -13.953 -21.969 1.00 22.00 ? 63 ASN A CA 1 ATOM 371 C C . ASN A 1 46 ? -4.797 -15.043 -21.262 1.00 21.54 ? 63 ASN A C 1 ATOM 372 O O . ASN A 1 46 ? -5.005 -14.952 -20.050 1.00 21.36 ? 63 ASN A O 1 ATOM 373 C CB . ASN A 1 46 ? -4.859 -12.809 -22.460 1.00 22.49 ? 63 ASN A CB 1 ATOM 374 C CG . ASN A 1 46 ? -4.053 -11.553 -22.757 1.00 23.27 ? 63 ASN A CG 1 ATOM 375 O OD1 . ASN A 1 46 ? -2.884 -11.436 -22.370 1.00 24.31 ? 63 ASN A OD1 1 ATOM 376 N ND2 . ASN A 1 46 ? -4.670 -10.610 -23.447 1.00 23.97 ? 63 ASN A ND2 1 ATOM 377 N N . GLU A 1 47 ? -5.221 -16.076 -21.992 1.00 21.00 ? 64 GLU A N 1 ATOM 378 C CA . GLU A 1 47 ? -5.901 -17.219 -21.347 1.00 21.22 ? 64 GLU A CA 1 ATOM 379 C C . GLU A 1 47 ? -4.965 -17.968 -20.408 1.00 20.85 ? 64 GLU A C 1 ATOM 380 O O . GLU A 1 47 ? -5.342 -18.295 -19.284 1.00 20.60 ? 64 GLU A O 1 ATOM 381 C CB . GLU A 1 47 ? -6.514 -18.186 -22.380 1.00 22.23 ? 64 GLU A CB 1 ATOM 382 C CG . GLU A 1 47 ? -7.144 -19.458 -21.784 1.00 23.59 ? 64 GLU A CG 1 ATOM 383 C CD . GLU A 1 47 ? -8.226 -19.208 -20.731 1.00 24.36 ? 64 GLU A CD 1 ATOM 384 O OE1 . GLU A 1 47 ? -8.877 -18.147 -20.759 1.00 25.77 ? 64 GLU A OE1 1 ATOM 385 O OE2 . GLU A 1 47 ? -8.460 -20.097 -19.871 1.00 24.74 ? 64 GLU A OE2 1 ATOM 386 N N . ILE A 1 48 ? -3.745 -18.246 -20.854 1.00 21.05 ? 65 ILE A N 1 ATOM 387 C CA . ILE A 1 48 ? -2.819 -18.991 -20.011 1.00 21.78 ? 65 ILE A CA 1 ATOM 388 C C . ILE A 1 48 ? -2.395 -18.186 -18.771 1.00 20.89 ? 65 ILE A C 1 ATOM 389 O O . ILE A 1 48 ? -2.283 -18.741 -17.678 1.00 20.27 ? 65 ILE A O 1 ATOM 390 C CB . ILE A 1 48 ? -1.628 -19.568 -20.809 1.00 23.80 ? 65 ILE A CB 1 ATOM 391 C CG1 . ILE A 1 48 ? -0.879 -20.607 -19.976 1.00 26.57 ? 65 ILE A CG1 1 ATOM 392 C CG2 . ILE A 1 48 ? -0.664 -18.497 -21.294 1.00 24.48 ? 65 ILE A CG2 1 ATOM 393 C CD1 . ILE A 1 48 ? -0.121 -21.577 -20.845 1.00 28.17 ? 65 ILE A CD1 1 ATOM 394 N N . SER A 1 49 ? -2.219 -16.876 -18.932 1.00 19.98 ? 66 SER A N 1 ATOM 395 C CA . SER A 1 49 ? -1.956 -16.001 -17.795 1.00 20.02 ? 66 SER A CA 1 ATOM 396 C C . SER A 1 49 ? -3.102 -16.002 -16.802 1.00 19.40 ? 66 SER A C 1 ATOM 397 O O . SER A 1 49 ? -2.870 -16.075 -15.599 1.00 19.15 ? 66 SER A O 1 ATOM 398 C CB . SER A 1 49 ? -1.684 -14.576 -18.267 1.00 21.02 ? 66 SER A CB 1 ATOM 399 O OG . SER A 1 49 ? -0.496 -14.557 -19.018 1.00 21.99 ? 66 SER A OG 1 ATOM 400 N N . ALA A 1 50 ? -4.338 -15.943 -17.303 1.00 19.24 ? 67 ALA A N 1 ATOM 401 C CA . ALA A 1 50 ? -5.515 -15.997 -16.441 1.00 19.64 ? 67 ALA A CA 1 ATOM 402 C C . ALA A 1 50 ? -5.576 -17.312 -15.664 1.00 20.00 ? 67 ALA A C 1 ATOM 403 O O . ALA A 1 50 ? -5.902 -17.308 -14.475 1.00 19.50 ? 67 ALA A O 1 ATOM 404 C CB . ALA A 1 50 ? -6.791 -15.791 -17.239 1.00 20.00 ? 67 ALA A CB 1 ATOM 405 N N . GLU A 1 51 ? -5.241 -18.424 -16.322 1.00 20.00 ? 68 GLU A N 1 ATOM 406 C CA . GLU A 1 51 ? -5.278 -19.731 -15.661 1.00 20.73 ? 68 GLU A CA 1 ATOM 407 C C . GLU A 1 51 ? -4.205 -19.830 -14.590 1.00 20.76 ? 68 GLU A C 1 ATOM 408 O O . GLU A 1 51 ? -4.449 -20.363 -13.503 1.00 20.25 ? 68 GLU A O 1 ATOM 409 C CB . GLU A 1 51 ? -5.154 -20.882 -16.664 1.00 20.64 ? 68 GLU A CB 1 ATOM 410 C CG . GLU A 1 51 ? -6.358 -21.006 -17.587 1.00 20.78 ? 68 GLU A CG 1 ATOM 411 C CD . GLU A 1 51 ? -6.194 -22.081 -18.653 1.00 21.37 ? 68 GLU A CD 1 ATOM 412 O OE1 . GLU A 1 51 ? -5.276 -22.915 -18.537 1.00 20.44 ? 68 GLU A OE1 1 ATOM 413 O OE2 . GLU A 1 51 ? -7.011 -22.104 -19.601 1.00 22.10 ? 68 GLU A OE2 1 ATOM 414 N N . LEU A 1 52 ? -3.030 -19.281 -14.882 1.00 20.86 ? 69 LEU A N 1 ATOM 415 C CA . LEU A 1 52 ? -1.965 -19.238 -13.903 1.00 22.39 ? 69 LEU A CA 1 ATOM 416 C C . LEU A 1 52 ? -2.310 -18.354 -12.704 1.00 22.17 ? 69 LEU A C 1 ATOM 417 O O . LEU A 1 52 ? -1.991 -18.712 -11.572 1.00 22.24 ? 69 LEU A O 1 ATOM 418 C CB . LEU A 1 52 ? -0.670 -18.786 -14.561 1.00 24.53 ? 69 LEU A CB 1 ATOM 419 C CG . LEU A 1 52 ? 0.597 -18.840 -13.713 1.00 26.54 ? 69 LEU A CG 1 ATOM 420 C CD1 . LEU A 1 52 ? 0.810 -20.203 -13.058 1.00 26.13 ? 69 LEU A CD1 1 ATOM 421 C CD2 . LEU A 1 52 ? 1.778 -18.461 -14.591 1.00 27.78 ? 69 LEU A CD2 1 ATOM 422 N N . ALA A 1 53 ? -2.981 -17.225 -12.933 1.00 22.15 ? 70 ALA A N 1 ATOM 423 C CA . ALA A 1 53 ? -3.368 -16.332 -11.832 1.00 22.13 ? 70 ALA A CA 1 ATOM 424 C C . ALA A 1 53 ? -4.344 -17.041 -10.899 1.00 22.89 ? 70 ALA A C 1 ATOM 425 O O . ALA A 1 53 ? -4.196 -16.963 -9.685 1.00 22.13 ? 70 ALA A O 1 ATOM 426 C CB . ALA A 1 53 ? -3.971 -15.039 -12.359 1.00 22.15 ? 70 ALA A CB 1 ATOM 427 N N . LYS A 1 54 ? -5.310 -17.762 -11.472 1.00 23.25 ? 71 LYS A N 1 ATOM 428 C CA . LYS A 1 54 ? -6.226 -18.585 -10.683 1.00 25.03 ? 71 LYS A CA 1 ATOM 429 C C . LYS A 1 54 ? -5.476 -19.634 -9.840 1.00 23.69 ? 71 LYS A C 1 ATOM 430 O O . LYS A 1 54 ? -5.814 -19.841 -8.674 1.00 22.43 ? 71 LYS A O 1 ATOM 431 C CB . LYS A 1 54 ? -7.271 -19.263 -11.578 1.00 27.51 ? 71 LYS A CB 1 ATOM 432 C CG . LYS A 1 54 ? -8.410 -19.923 -10.809 1.00 31.33 ? 71 LYS A CG 1 ATOM 433 C CD . LYS A 1 54 ? -9.079 -21.058 -11.580 1.00 34.27 ? 71 LYS A CD 1 ATOM 434 C CE . LYS A 1 54 ? -10.107 -20.557 -12.575 1.00 35.83 ? 71 LYS A CE 1 ATOM 435 N NZ . LYS A 1 54 ? -10.833 -21.695 -13.221 1.00 36.19 ? 71 LYS A NZ 1 ATOM 436 N N . PHE A 1 55 ? -4.466 -20.276 -10.428 1.00 22.58 ? 72 PHE A N 1 ATOM 437 C CA . PHE A 1 55 ? -3.616 -21.232 -9.707 1.00 23.15 ? 72 PHE A CA 1 ATOM 438 C C . PHE A 1 55 ? -2.886 -20.549 -8.546 1.00 23.25 ? 72 PHE A C 1 ATOM 439 O O . PHE A 1 55 ? -2.827 -21.093 -7.438 1.00 21.56 ? 72 PHE A O 1 ATOM 440 C CB . PHE A 1 55 ? -2.618 -21.896 -10.669 1.00 23.22 ? 72 PHE A CB 1 ATOM 441 C CG . PHE A 1 55 ? -1.751 -22.963 -10.040 1.00 23.83 ? 72 PHE A CG 1 ATOM 442 C CD1 . PHE A 1 55 ? -2.295 -24.187 -9.647 1.00 23.77 ? 72 PHE A CD1 1 ATOM 443 C CD2 . PHE A 1 55 ? -0.374 -22.770 -9.885 1.00 24.23 ? 72 PHE A CD2 1 ATOM 444 C CE1 . PHE A 1 55 ? -1.497 -25.177 -9.092 1.00 24.48 ? 72 PHE A CE1 1 ATOM 445 C CE2 . PHE A 1 55 ? 0.426 -23.764 -9.326 1.00 24.03 ? 72 PHE A CE2 1 ATOM 446 C CZ . PHE A 1 55 ? -0.136 -24.971 -8.938 1.00 23.74 ? 72 PHE A CZ 1 ATOM 447 N N . MET A 1 56 ? -2.348 -19.355 -8.791 1.00 23.43 ? 73 MET A N 1 ATOM 448 C CA . MET A 1 56 ? -1.634 -18.618 -7.741 1.00 24.23 ? 73 MET A CA 1 ATOM 449 C C . MET A 1 56 ? -2.532 -18.272 -6.567 1.00 23.32 ? 73 MET A C 1 ATOM 450 O O . MET A 1 56 ? -2.092 -18.357 -5.423 1.00 22.05 ? 73 MET A O 1 ATOM 451 C CB . MET A 1 56 ? -0.994 -17.326 -8.282 1.00 25.95 ? 73 MET A CB 1 ATOM 452 C CG . MET A 1 56 ? 0.058 -17.507 -9.357 1.00 27.00 ? 73 MET A CG 1 ATOM 453 S SD . MET A 1 56 ? 1.180 -18.868 -9.037 1.00 32.68 ? 73 MET A SD 1 ATOM 454 C CE . MET A 1 56 ? 1.890 -18.393 -7.468 1.00 31.86 ? 73 MET A CE 1 ATOM 455 N N . LYS A 1 57 ? -3.775 -17.877 -6.842 1.00 23.32 ? 74 LYS A N 1 ATOM 456 C CA . LYS A 1 57 ? -4.770 -17.681 -5.781 1.00 24.95 ? 74 LYS A CA 1 ATOM 457 C C . LYS A 1 57 ? -4.924 -18.929 -4.912 1.00 27.13 ? 74 LYS A C 1 ATOM 458 O O . LYS A 1 57 ? -4.947 -18.826 -3.677 1.00 27.67 ? 74 LYS A O 1 ATOM 459 C CB . LYS A 1 57 ? -6.143 -17.316 -6.346 1.00 26.05 ? 74 LYS A CB 1 ATOM 460 C CG . LYS A 1 57 ? -6.291 -15.894 -6.844 1.00 26.48 ? 74 LYS A CG 1 ATOM 461 C CD . LYS A 1 57 ? -7.753 -15.619 -7.192 1.00 27.08 ? 74 LYS A CD 1 ATOM 462 C CE . LYS A 1 57 ? -7.988 -14.207 -7.699 1.00 27.30 ? 74 LYS A CE 1 ATOM 463 N NZ . LYS A 1 57 ? -7.369 -13.992 -9.037 1.00 28.10 ? 74 LYS A NZ 1 ATOM 464 N N . GLU A 1 58 ? -5.020 -20.093 -5.553 1.00 28.03 ? 75 GLU A N 1 ATOM 465 C CA . GLU A 1 58 ? -5.144 -21.365 -4.829 1.00 31.52 ? 75 GLU A CA 1 ATOM 466 C C . GLU A 1 58 ? -3.908 -21.637 -3.975 1.00 31.05 ? 75 GLU A C 1 ATOM 467 O O . GLU A 1 58 ? -4.034 -22.067 -2.824 1.00 32.54 ? 75 GLU A O 1 ATOM 468 C CB . GLU A 1 58 ? -5.368 -22.539 -5.783 1.00 33.75 ? 75 GLU A CB 1 ATOM 469 C CG . GLU A 1 58 ? -6.699 -22.502 -6.520 1.00 38.29 ? 75 GLU A CG 1 ATOM 470 C CD . GLU A 1 58 ? -6.827 -23.576 -7.598 1.00 42.25 ? 75 GLU A CD 1 ATOM 471 O OE1 . GLU A 1 58 ? -6.016 -24.542 -7.612 1.00 44.20 ? 75 GLU A OE1 1 ATOM 472 O OE2 . GLU A 1 58 ? -7.755 -23.448 -8.436 1.00 45.29 ? 75 GLU A OE2 1 ATOM 473 N N . VAL A 1 59 ? -2.732 -21.385 -4.547 1.00 29.32 ? 76 VAL A N 1 ATOM 474 C CA . VAL A 1 59 ? -1.454 -21.540 -3.843 1.00 30.93 ? 76 VAL A CA 1 ATOM 475 C C . VAL A 1 59 ? -1.423 -20.689 -2.578 1.00 31.32 ? 76 VAL A C 1 ATOM 476 O O . VAL A 1 59 ? -1.107 -21.198 -1.496 1.00 32.02 ? 76 VAL A O 1 ATOM 477 C CB . VAL A 1 59 ? -0.248 -21.192 -4.755 1.00 30.89 ? 76 VAL A CB 1 ATOM 478 C CG1 . VAL A 1 59 ? 1.046 -21.029 -3.963 1.00 31.00 ? 76 VAL A CG1 1 ATOM 479 C CG2 . VAL A 1 59 ? -0.071 -22.265 -5.815 1.00 30.99 ? 76 VAL A CG2 1 ATOM 480 N N . ALA A 1 60 ? -1.757 -19.409 -2.718 1.00 30.46 ? 77 ALA A N 1 ATOM 481 C CA . ALA A 1 60 ? -1.759 -18.475 -1.586 1.00 32.17 ? 77 ALA A CA 1 ATOM 482 C C . ALA A 1 60 ? -2.696 -18.929 -0.472 1.00 33.32 ? 77 ALA A C 1 ATOM 483 O O . ALA A 1 60 ? -2.360 -18.823 0.705 1.00 33.69 ? 77 ALA A O 1 ATOM 484 C CB . ALA A 1 60 ? -2.131 -17.071 -2.045 1.00 31.78 ? 77 ALA A CB 1 ATOM 485 N N . SER A 1 61 ? -3.861 -19.440 -0.852 1.00 35.41 ? 78 SER A N 1 ATOM 486 C CA . SER A 1 61 ? -4.785 -20.056 0.099 1.00 37.54 ? 78 SER A CA 1 ATOM 487 C C . SER A 1 61 ? -4.198 -21.328 0.733 1.00 38.98 ? 78 SER A C 1 ATOM 488 O O . SER A 1 61 ? -4.293 -21.510 1.941 1.00 38.85 ? 78 SER A O 1 ATOM 489 C CB . SER A 1 61 ? -6.118 -20.373 -0.586 1.00 38.85 ? 78 SER A CB 1 ATOM 490 O OG . SER A 1 61 ? -7.001 -21.047 0.294 1.00 42.33 ? 78 SER A OG 1 ATOM 491 N N . ASP A 1 62 ? -3.596 -22.196 -0.078 1.00 39.84 ? 79 ASP A N 1 ATOM 492 C CA . ASP A 1 62 ? -3.015 -23.460 0.421 1.00 41.20 ? 79 ASP A CA 1 ATOM 493 C C . ASP A 1 62 ? -1.888 -23.263 1.433 1.00 41.50 ? 79 ASP A C 1 ATOM 494 O O . ASP A 1 62 ? -1.727 -24.091 2.328 1.00 41.99 ? 79 ASP A O 1 ATOM 495 C CB . ASP A 1 62 ? -2.500 -24.341 -0.728 1.00 42.56 ? 79 ASP A CB 1 ATOM 496 C CG . ASP A 1 62 ? -3.613 -24.941 -1.561 1.00 43.57 ? 79 ASP A CG 1 ATOM 497 O OD1 . ASP A 1 62 ? -4.799 -24.791 -1.207 1.00 46.24 ? 79 ASP A OD1 1 ATOM 498 O OD2 . ASP A 1 62 ? -3.298 -25.570 -2.588 1.00 46.31 ? 79 ASP A OD2 1 ATOM 499 N N . THR A 1 63 ? -1.122 -22.179 1.300 1.00 40.13 ? 80 THR A N 1 ATOM 500 C CA . THR A 1 63 ? -0.048 -21.878 2.258 1.00 40.96 ? 80 THR A CA 1 ATOM 501 C C . THR A 1 63 ? -0.562 -21.701 3.697 1.00 39.18 ? 80 THR A C 1 ATOM 502 O O . THR A 1 63 ? 0.179 -21.953 4.645 1.00 38.07 ? 80 THR A O 1 ATOM 503 C CB . THR A 1 63 ? 0.759 -20.608 1.889 1.00 40.07 ? 80 THR A CB 1 ATOM 504 O OG1 . THR A 1 63 ? -0.079 -19.451 1.980 1.00 40.45 ? 80 THR A OG1 1 ATOM 505 C CG2 . THR A 1 63 ? 1.361 -20.707 0.487 1.00 41.21 ? 80 THR A CG2 1 ATOM 506 N N . THR A 1 64 ? -1.816 -21.274 3.855 1.00 38.81 ? 81 THR A N 1 ATOM 507 C CA . THR A 1 64 ? -2.402 -21.074 5.189 1.00 38.68 ? 81 THR A CA 1 ATOM 508 C C . THR A 1 64 ? -2.576 -22.386 5.975 1.00 39.46 ? 81 THR A C 1 ATOM 509 O O . THR A 1 64 ? -2.706 -22.348 7.193 1.00 40.34 ? 81 THR A O 1 ATOM 510 C CB . THR A 1 64 ? -3.756 -20.332 5.130 1.00 38.79 ? 81 THR A CB 1 ATOM 511 O OG1 . THR A 1 64 ? -4.737 -21.172 4.517 1.00 36.86 ? 81 THR A OG1 1 ATOM 512 C CG2 . THR A 1 64 ? -3.638 -19.008 4.346 1.00 38.63 ? 81 THR A CG2 1 ATOM 513 N N . LYS A 1 65 ? -2.587 -23.526 5.277 1.00 39.90 ? 82 LYS A N 1 ATOM 514 C CA . LYS A 1 65 ? -2.543 -24.863 5.914 1.00 41.21 ? 82 LYS A CA 1 ATOM 515 C C . LYS A 1 65 ? -1.268 -25.148 6.714 1.00 39.38 ? 82 LYS A C 1 ATOM 516 O O . LYS A 1 65 ? -1.267 -26.037 7.568 1.00 39.52 ? 82 LYS A O 1 ATOM 517 C CB . LYS A 1 65 ? -2.704 -25.987 4.872 1.00 45.20 ? 82 LYS A CB 1 ATOM 518 C CG . LYS A 1 65 ? -4.051 -26.691 4.892 1.00 50.51 ? 82 LYS A CG 1 ATOM 519 C CD . LYS A 1 65 ? -4.205 -27.649 3.714 1.00 53.89 ? 82 LYS A CD 1 ATOM 520 C CE . LYS A 1 65 ? -4.579 -26.930 2.424 1.00 56.24 ? 82 LYS A CE 1 ATOM 521 N NZ . LYS A 1 65 ? -5.835 -26.132 2.559 1.00 58.97 ? 82 LYS A NZ 1 ATOM 522 N N . PHE A 1 66 ? -0.185 -24.434 6.404 1.00 35.12 ? 83 PHE A N 1 ATOM 523 C CA . PHE A 1 66 ? 1.105 -24.630 7.049 1.00 33.26 ? 83 PHE A CA 1 ATOM 524 C C . PHE A 1 66 ? 1.369 -23.506 8.045 1.00 32.41 ? 83 PHE A C 1 ATOM 525 O O . PHE A 1 66 ? 1.226 -22.335 7.696 1.00 31.18 ? 83 PHE A O 1 ATOM 526 C CB . PHE A 1 66 ? 2.207 -24.650 5.990 1.00 32.13 ? 83 PHE A CB 1 ATOM 527 C CG . PHE A 1 66 ? 2.075 -25.773 5.010 1.00 31.92 ? 83 PHE A CG 1 ATOM 528 C CD1 . PHE A 1 66 ? 2.517 -27.052 5.333 1.00 31.56 ? 83 PHE A CD1 1 ATOM 529 C CD2 . PHE A 1 66 ? 1.495 -25.560 3.764 1.00 32.05 ? 83 PHE A CD2 1 ATOM 530 C CE1 . PHE A 1 66 ? 2.385 -28.101 4.434 1.00 32.30 ? 83 PHE A CE1 1 ATOM 531 C CE2 . PHE A 1 66 ? 1.360 -26.604 2.858 1.00 32.12 ? 83 PHE A CE2 1 ATOM 532 C CZ . PHE A 1 66 ? 1.807 -27.876 3.193 1.00 32.64 ? 83 PHE A CZ 1 ATOM 533 N N . GLN A 1 67 ? 1.769 -23.868 9.266 1.00 31.43 ? 84 GLN A N 1 ATOM 534 C CA . GLN A 1 67 ? 2.148 -22.903 10.308 1.00 32.81 ? 84 GLN A CA 1 ATOM 535 C C . GLN A 1 67 ? 3.583 -22.442 10.059 1.00 29.87 ? 84 GLN A C 1 ATOM 536 O O . GLN A 1 67 ? 4.461 -22.632 10.909 1.00 28.02 ? 84 GLN A O 1 ATOM 537 C CB . GLN A 1 67 ? 2.057 -23.546 11.702 1.00 35.88 ? 84 GLN A CB 1 ATOM 538 C CG . GLN A 1 67 ? 0.674 -24.021 12.105 1.00 39.69 ? 84 GLN A CG 1 ATOM 539 C CD . GLN A 1 67 ? -0.167 -22.907 12.678 1.00 43.14 ? 84 GLN A CD 1 ATOM 540 O OE1 . GLN A 1 67 ? 0.079 -22.437 13.794 1.00 46.64 ? 84 GLN A OE1 1 ATOM 541 N NE2 . GLN A 1 67 ? -1.170 -22.477 11.921 1.00 46.07 ? 84 GLN A NE2 1 ATOM 542 N N . TRP A 1 68 ? 3.823 -21.831 8.899 1.00 28.09 ? 85 TRP A N 1 ATOM 543 C CA . TRP A 1 68 ? 5.197 -21.654 8.415 1.00 28.79 ? 85 TRP A CA 1 ATOM 544 C C . TRP A 1 68 ? 5.981 -20.572 9.163 1.00 29.18 ? 85 TRP A C 1 ATOM 545 O O . TRP A 1 68 ? 7.207 -20.632 9.221 1.00 28.83 ? 85 TRP A O 1 ATOM 546 C CB . TRP A 1 68 ? 5.265 -21.458 6.888 1.00 28.65 ? 85 TRP A CB 1 ATOM 547 C CG . TRP A 1 68 ? 4.535 -20.276 6.359 1.00 28.67 ? 85 TRP A CG 1 ATOM 548 C CD1 . TRP A 1 68 ? 3.286 -20.269 5.812 1.00 29.10 ? 85 TRP A CD1 1 ATOM 549 C CD2 . TRP A 1 68 ? 5.004 -18.927 6.304 1.00 29.00 ? 85 TRP A CD2 1 ATOM 550 N NE1 . TRP A 1 68 ? 2.940 -18.998 5.437 1.00 29.54 ? 85 TRP A NE1 1 ATOM 551 C CE2 . TRP A 1 68 ? 3.978 -18.153 5.719 1.00 29.16 ? 85 TRP A CE2 1 ATOM 552 C CE3 . TRP A 1 68 ? 6.190 -18.295 6.693 1.00 29.01 ? 85 TRP A CE3 1 ATOM 553 C CZ2 . TRP A 1 68 ? 4.100 -16.779 5.513 1.00 29.33 ? 85 TRP A CZ2 1 ATOM 554 C CZ3 . TRP A 1 68 ? 6.311 -16.922 6.489 1.00 29.96 ? 85 TRP A CZ3 1 ATOM 555 C CH2 . TRP A 1 68 ? 5.274 -16.183 5.901 1.00 29.87 ? 85 TRP A CH2 1 ATOM 556 N N . ARG A 1 69 ? 5.287 -19.623 9.782 1.00 29.76 ? 86 ARG A N 1 ATOM 557 C CA . ARG A 1 69 ? 5.961 -18.658 10.658 1.00 31.20 ? 86 ARG A CA 1 ATOM 558 C C . ARG A 1 69 ? 6.625 -19.290 11.891 1.00 29.51 ? 86 ARG A C 1 ATOM 559 O O . ARG A 1 69 ? 7.506 -18.683 12.489 1.00 30.52 ? 86 ARG A O 1 ATOM 560 C CB . ARG A 1 69 ? 5.000 -17.550 11.079 1.00 33.40 ? 86 ARG A CB 1 ATOM 561 C CG . ARG A 1 69 ? 4.585 -16.655 9.924 1.00 36.77 ? 86 ARG A CG 1 ATOM 562 C CD . ARG A 1 69 ? 3.462 -15.720 10.337 1.00 39.21 ? 86 ARG A CD 1 ATOM 563 N NE . ARG A 1 69 ? 2.910 -14.993 9.191 1.00 42.38 ? 86 ARG A NE 1 ATOM 564 C CZ . ARG A 1 69 ? 2.026 -15.471 8.309 1.00 44.11 ? 86 ARG A CZ 1 ATOM 565 N NH1 . ARG A 1 69 ? 1.553 -16.717 8.390 1.00 44.73 ? 86 ARG A NH1 1 ATOM 566 N NH2 . ARG A 1 69 ? 1.610 -14.683 7.318 1.00 44.57 ? 86 ARG A NH2 1 ATOM 567 N N . SER A 1 70 ? 6.216 -20.499 12.265 1.00 28.15 ? 87 SER A N 1 ATOM 568 C CA . SER A 1 70 ? 6.845 -21.227 13.370 1.00 28.00 ? 87 SER A CA 1 ATOM 569 C C . SER A 1 70 ? 7.979 -22.151 12.945 1.00 26.96 ? 87 SER A C 1 ATOM 570 O O . SER A 1 70 ? 8.609 -22.756 13.802 1.00 26.24 ? 87 SER A O 1 ATOM 571 C CB . SER A 1 70 ? 5.794 -22.032 14.138 1.00 28.34 ? 87 SER A CB 1 ATOM 572 O OG . SER A 1 70 ? 4.824 -21.158 14.673 1.00 30.27 ? 87 SER A OG 1 ATOM 573 N N . TYR A 1 71 ? 8.260 -22.254 11.643 1.00 25.58 ? 88 TYR A N 1 ATOM 574 C CA . TYR A 1 71 ? 9.316 -23.143 11.161 1.00 24.73 ? 88 TYR A CA 1 ATOM 575 C C . TYR A 1 71 ? 10.707 -22.628 11.481 1.00 24.17 ? 88 TYR A C 1 ATOM 576 O O . TYR A 1 71 ? 10.922 -21.428 11.656 1.00 24.18 ? 88 TYR A O 1 ATOM 577 C CB . TYR A 1 71 ? 9.209 -23.388 9.645 1.00 25.32 ? 88 TYR A CB 1 ATOM 578 C CG . TYR A 1 71 ? 7.962 -24.137 9.183 1.00 24.84 ? 88 TYR A CG 1 ATOM 579 C CD1 . TYR A 1 71 ? 7.115 -24.810 10.084 1.00 25.45 ? 88 TYR A CD1 1 ATOM 580 C CD2 . TYR A 1 71 ? 7.639 -24.185 7.830 1.00 25.37 ? 88 TYR A CD2 1 ATOM 581 C CE1 . TYR A 1 71 ? 5.981 -25.478 9.643 1.00 25.15 ? 88 TYR A CE1 1 ATOM 582 C CE2 . TYR A 1 71 ? 6.504 -24.846 7.383 1.00 25.50 ? 88 TYR A CE2 1 ATOM 583 C CZ . TYR A 1 71 ? 5.680 -25.491 8.293 1.00 26.27 ? 88 TYR A CZ 1 ATOM 584 O OH . TYR A 1 71 ? 4.555 -26.149 7.857 1.00 26.81 ? 88 TYR A OH 1 ATOM 585 N N . GLN A 1 72 ? 11.642 -23.566 11.561 1.00 23.67 ? 89 GLN A N 1 ATOM 586 C CA . GLN A 1 72 ? 13.043 -23.250 11.803 1.00 24.71 ? 89 GLN A CA 1 ATOM 587 C C . GLN A 1 72 ? 13.762 -22.696 10.582 1.00 25.28 ? 89 GLN A C 1 ATOM 588 O O . GLN A 1 72 ? 14.596 -21.787 10.722 1.00 24.52 ? 89 GLN A O 1 ATOM 589 C CB . GLN A 1 72 ? 13.780 -24.480 12.338 1.00 24.84 ? 89 GLN A CB 1 ATOM 590 C CG . GLN A 1 72 ? 13.297 -24.918 13.717 1.00 25.10 ? 89 GLN A CG 1 ATOM 591 C CD . GLN A 1 72 ? 13.462 -23.822 14.752 1.00 26.43 ? 89 GLN A CD 1 ATOM 592 O OE1 . GLN A 1 72 ? 14.357 -22.980 14.644 1.00 26.37 ? 89 GLN A OE1 1 ATOM 593 N NE2 . GLN A 1 72 ? 12.588 -23.805 15.743 1.00 27.34 ? 89 GLN A NE2 1 ATOM 594 N N . SER A 1 73 ? 13.462 -23.238 9.401 1.00 24.27 ? 90 SER A N 1 ATOM 595 C CA . SER A 1 73 ? 14.208 -22.876 8.190 1.00 24.84 ? 90 SER A CA 1 ATOM 596 C C . SER A 1 73 ? 13.820 -21.504 7.657 1.00 24.11 ? 90 SER A C 1 ATOM 597 O O . SER A 1 73 ? 12.704 -21.313 7.171 1.00 23.09 ? 90 SER A O 1 ATOM 598 C CB . SER A 1 73 ? 14.002 -23.910 7.084 1.00 25.40 ? 90 SER A CB 1 ATOM 599 O OG . SER A 1 73 ? 14.609 -23.465 5.891 1.00 25.66 ? 90 SER A OG 1 ATOM 600 N N . GLU A 1 74 ? 14.760 -20.563 7.709 1.00 24.70 ? 91 GLU A N 1 ATOM 601 C CA . GLU A 1 74 ? 14.552 -19.246 7.110 1.00 26.54 ? 91 GLU A CA 1 ATOM 602 C C . GLU A 1 74 ? 14.321 -19.365 5.600 1.00 24.38 ? 91 GLU A C 1 ATOM 603 O O . GLU A 1 74 ? 13.534 -18.610 5.029 1.00 22.31 ? 91 GLU A O 1 ATOM 604 C CB . GLU A 1 74 ? 15.735 -18.306 7.405 1.00 30.47 ? 91 GLU A CB 1 ATOM 605 C CG . GLU A 1 74 ? 15.622 -16.908 6.792 1.00 35.57 ? 91 GLU A CG 1 ATOM 606 C CD . GLU A 1 74 ? 14.304 -16.195 7.098 1.00 40.61 ? 91 GLU A CD 1 ATOM 607 O OE1 . GLU A 1 74 ? 13.905 -16.151 8.291 1.00 45.27 ? 91 GLU A OE1 1 ATOM 608 O OE2 . GLU A 1 74 ? 13.670 -15.672 6.142 1.00 43.13 ? 91 GLU A OE2 1 ATOM 609 N N . ASP A 1 75 ? 15.004 -20.318 4.973 1.00 23.42 ? 92 ASP A N 1 ATOM 610 C CA . ASP A 1 75 ? 14.822 -20.574 3.551 1.00 23.98 ? 92 ASP A CA 1 ATOM 611 C C . ASP A 1 75 ? 13.372 -20.940 3.228 1.00 22.53 ? 92 ASP A C 1 ATOM 612 O O . ASP A 1 75 ? 12.786 -20.360 2.323 1.00 22.19 ? 92 ASP A O 1 ATOM 613 C CB . ASP A 1 75 ? 15.780 -21.668 3.074 1.00 24.41 ? 92 ASP A CB 1 ATOM 614 C CG . ASP A 1 75 ? 15.660 -21.935 1.595 1.00 25.84 ? 92 ASP A CG 1 ATOM 615 O OD1 . ASP A 1 75 ? 15.434 -20.990 0.834 1.00 27.73 ? 92 ASP A OD1 1 ATOM 616 O OD2 . ASP A 1 75 ? 15.793 -23.089 1.182 1.00 28.54 ? 92 ASP A OD2 1 ATOM 617 N N . LEU A 1 76 ? 12.791 -21.887 3.966 1.00 21.79 ? 93 LEU A N 1 ATOM 618 C CA . LEU A 1 76 ? 11.392 -22.281 3.730 1.00 21.87 ? 93 LEU A CA 1 ATOM 619 C C . LEU A 1 76 ? 10.448 -21.122 3.981 1.00 20.85 ? 93 LEU A C 1 ATOM 620 O O . LEU A 1 76 ? 9.507 -20.919 3.227 1.00 20.62 ? 93 LEU A O 1 ATOM 621 C CB . LEU A 1 76 ? 10.963 -23.465 4.610 1.00 22.83 ? 93 LEU A CB 1 ATOM 622 C CG . LEU A 1 76 ? 11.663 -24.810 4.411 1.00 23.87 ? 93 LEU A CG 1 ATOM 623 C CD1 . LEU A 1 76 ? 10.928 -25.860 5.239 1.00 24.26 ? 93 LEU A CD1 1 ATOM 624 C CD2 . LEU A 1 76 ? 11.760 -25.229 2.947 1.00 23.84 ? 93 LEU A CD2 1 ATOM 625 N N . LYS A 1 77 ? 10.705 -20.364 5.042 1.00 20.23 ? 94 LYS A N 1 ATOM 626 C CA . LYS A 1 77 ? 9.911 -19.179 5.348 1.00 20.77 ? 94 LYS A CA 1 ATOM 627 C C . LYS A 1 77 ? 9.996 -18.126 4.247 1.00 19.71 ? 94 LYS A C 1 ATOM 628 O O . LYS A 1 77 ? 9.000 -17.497 3.908 1.00 20.75 ? 94 LYS A O 1 ATOM 629 C CB . LYS A 1 77 ? 10.330 -18.589 6.705 1.00 21.14 ? 94 LYS A CB 1 ATOM 630 C CG . LYS A 1 77 ? 9.927 -19.493 7.863 1.00 21.77 ? 94 LYS A CG 1 ATOM 631 C CD . LYS A 1 77 ? 10.023 -18.802 9.207 1.00 22.74 ? 94 LYS A CD 1 ATOM 632 C CE . LYS A 1 77 ? 11.466 -18.590 9.618 1.00 24.40 ? 94 LYS A CE 1 ATOM 633 N NZ . LYS A 1 77 ? 11.549 -18.181 11.050 1.00 25.20 ? 94 LYS A NZ 1 ATOM 634 N N . ARG A 1 78 ? 11.178 -17.946 3.682 1.00 20.09 ? 95 ARG A N 1 ATOM 635 C CA . ARG A 1 78 ? 11.338 -17.022 2.558 1.00 19.87 ? 95 ARG A CA 1 ATOM 636 C C . ARG A 1 78 ? 10.518 -17.474 1.343 1.00 19.62 ? 95 ARG A C 1 ATOM 637 O O . ARG A 1 78 ? 9.869 -16.660 0.686 1.00 18.86 ? 95 ARG A O 1 ATOM 638 C CB . ARG A 1 78 ? 12.808 -16.889 2.194 1.00 19.76 ? 95 ARG A CB 1 ATOM 639 C CG . ARG A 1 78 ? 13.075 -15.886 1.078 1.00 19.91 ? 95 ARG A CG 1 ATOM 640 C CD . ARG A 1 78 ? 14.561 -15.696 0.886 1.00 19.72 ? 95 ARG A CD 1 ATOM 641 N NE . ARG A 1 78 ? 14.888 -14.771 -0.208 1.00 20.04 ? 95 ARG A NE 1 ATOM 642 C CZ . ARG A 1 78 ? 14.845 -13.436 -0.142 1.00 20.89 ? 95 ARG A CZ 1 ATOM 643 N NH1 . ARG A 1 78 ? 14.455 -12.809 0.963 1.00 20.54 ? 95 ARG A NH1 1 ATOM 644 N NH2 . ARG A 1 78 ? 15.180 -12.710 -1.208 1.00 20.89 ? 95 ARG A NH2 1 ATOM 645 N N . GLN A 1 79 ? 10.541 -18.772 1.063 1.00 19.83 ? 96 GLN A N 1 ATOM 646 C CA . GLN A 1 79 ? 9.788 -19.321 -0.064 1.00 19.85 ? 96 GLN A CA 1 ATOM 647 C C . GLN A 1 79 ? 8.291 -19.153 0.141 1.00 20.60 ? 96 GLN A C 1 ATOM 648 O O . GLN A 1 79 ? 7.599 -18.699 -0.775 1.00 20.84 ? 96 GLN A O 1 ATOM 649 C CB . GLN A 1 79 ? 10.140 -20.787 -0.299 1.00 19.72 ? 96 GLN A CB 1 ATOM 650 C CG . GLN A 1 79 ? 11.583 -21.014 -0.742 1.00 19.28 ? 96 GLN A CG 1 ATOM 651 C CD . GLN A 1 79 ? 11.843 -22.433 -1.206 1.00 19.42 ? 96 GLN A CD 1 ATOM 652 O OE1 . GLN A 1 79 ? 11.083 -22.988 -1.978 1.00 19.58 ? 96 GLN A OE1 1 ATOM 653 N NE2 . GLN A 1 79 ? 12.922 -23.023 -0.736 1.00 19.74 ? 96 GLN A NE2 1 ATOM 654 N N . PHE A 1 80 ? 7.790 -19.512 1.333 1.00 20.94 ? 97 PHE A N 1 ATOM 655 C CA . PHE A 1 80 ? 6.370 -19.340 1.644 1.00 22.15 ? 97 PHE A CA 1 ATOM 656 C C . PHE A 1 80 ? 5.931 -17.889 1.488 1.00 23.71 ? 97 PHE A C 1 ATOM 657 O O . PHE A 1 80 ? 4.930 -17.607 0.832 1.00 24.36 ? 97 PHE A O 1 ATOM 658 C CB . PHE A 1 80 ? 6.020 -19.839 3.056 1.00 22.60 ? 97 PHE A CB 1 ATOM 659 C CG . PHE A 1 80 ? 5.698 -21.304 3.113 1.00 22.49 ? 97 PHE A CG 1 ATOM 660 C CD1 . PHE A 1 80 ? 4.493 -21.775 2.600 1.00 22.79 ? 97 PHE A CD1 1 ATOM 661 C CD2 . PHE A 1 80 ? 6.590 -22.216 3.670 1.00 23.22 ? 97 PHE A CD2 1 ATOM 662 C CE1 . PHE A 1 80 ? 4.187 -23.128 2.647 1.00 23.40 ? 97 PHE A CE1 1 ATOM 663 C CE2 . PHE A 1 80 ? 6.290 -23.572 3.719 1.00 23.56 ? 97 PHE A CE2 1 ATOM 664 C CZ . PHE A 1 80 ? 5.084 -24.027 3.209 1.00 23.69 ? 97 PHE A CZ 1 ATOM 665 N N . LYS A 1 81 ? 6.692 -16.971 2.076 1.00 25.35 ? 98 LYS A N 1 ATOM 666 C CA . LYS A 1 81 ? 6.365 -15.545 1.982 1.00 27.33 ? 98 LYS A CA 1 ATOM 667 C C . LYS A 1 81 ? 6.313 -15.054 0.527 1.00 26.85 ? 98 LYS A C 1 ATOM 668 O O . LYS A 1 81 ? 5.385 -14.333 0.153 1.00 26.69 ? 98 LYS A O 1 ATOM 669 C CB . LYS A 1 81 ? 7.339 -14.706 2.812 1.00 29.56 ? 98 LYS A CB 1 ATOM 670 C CG . LYS A 1 81 ? 6.989 -13.226 2.874 1.00 34.14 ? 98 LYS A CG 1 ATOM 671 C CD . LYS A 1 81 ? 7.873 -12.499 3.883 1.00 37.38 ? 98 LYS A CD 1 ATOM 672 C CE . LYS A 1 81 ? 8.332 -11.133 3.390 1.00 40.35 ? 98 LYS A CE 1 ATOM 673 N NZ . LYS A 1 81 ? 7.244 -10.125 3.493 1.00 42.04 ? 98 LYS A NZ 1 ATOM 674 N N . ALA A 1 82 ? 7.277 -15.459 -0.293 1.00 27.08 ? 99 ALA A N 1 ATOM 675 C CA . ALA A 1 82 ? 7.281 -15.067 -1.717 1.00 28.87 ? 99 ALA A CA 1 ATOM 676 C C . ALA A 1 82 ? 6.049 -15.609 -2.449 1.00 30.86 ? 99 ALA A C 1 ATOM 677 O O . ALA A 1 82 ? 5.468 -14.921 -3.286 1.00 31.04 ? 99 ALA A O 1 ATOM 678 C CB . ALA A 1 82 ? 8.564 -15.521 -2.404 1.00 28.84 ? 99 ALA A CB 1 ATOM 679 N N . LEU A 1 83 ? 5.639 -16.828 -2.097 1.00 32.84 ? 100 LEU A N 1 ATOM 680 C CA . LEU A 1 83 ? 4.435 -17.454 -2.648 1.00 34.13 ? 100 LEU A CA 1 ATOM 681 C C . LEU A 1 83 ? 3.111 -16.905 -2.116 1.00 34.13 ? 100 LEU A C 1 ATOM 682 O O . LEU A 1 83 ? 2.062 -17.196 -2.682 1.00 37.13 ? 100 LEU A O 1 ATOM 683 C CB . LEU A 1 83 ? 4.482 -18.969 -2.414 1.00 35.77 ? 100 LEU A CB 1 ATOM 684 C CG . LEU A 1 83 ? 5.592 -19.693 -3.182 1.00 37.61 ? 100 LEU A CG 1 ATOM 685 C CD1 . LEU A 1 83 ? 5.852 -21.071 -2.589 1.00 39.31 ? 100 LEU A CD1 1 ATOM 686 C CD2 . LEU A 1 83 ? 5.256 -19.796 -4.663 1.00 39.52 ? 100 LEU A CD2 1 ATOM 687 N N . THR A 1 84 ? 3.127 -16.152 -1.023 1.00 33.50 ? 101 THR A N 1 ATOM 688 C CA . THR A 1 84 ? 1.919 -15.464 -0.575 1.00 32.98 ? 101 THR A CA 1 ATOM 689 C C . THR A 1 84 ? 1.672 -14.174 -1.361 1.00 30.50 ? 101 THR A C 1 ATOM 690 O O . THR A 1 84 ? 0.574 -13.646 -1.309 1.00 28.75 ? 101 THR A O 1 ATOM 691 C CB . THR A 1 84 ? 1.948 -15.111 0.933 1.00 35.08 ? 101 THR A CB 1 ATOM 692 O OG1 . THR A 1 84 ? 2.956 -14.118 1.193 1.00 37.74 ? 101 THR A OG1 1 ATOM 693 C CG2 . THR A 1 84 ? 2.190 -16.354 1.796 1.00 35.75 ? 101 THR A CG2 1 ATOM 694 N N . LYS A 1 85 ? 2.690 -13.660 -2.057 1.00 28.29 ? 102 LYS A N 1 ATOM 695 C CA . LYS A 1 85 ? 2.603 -12.364 -2.748 1.00 27.53 ? 102 LYS A CA 1 ATOM 696 C C . LYS A 1 85 ? 2.003 -12.530 -4.139 1.00 26.29 ? 102 LYS A C 1 ATOM 697 O O . LYS A 1 85 ? 2.689 -12.946 -5.065 1.00 27.08 ? 102 LYS A O 1 ATOM 698 C CB . LYS A 1 85 ? 3.992 -11.725 -2.882 1.00 28.32 ? 102 LYS A CB 1 ATOM 699 C CG . LYS A 1 85 ? 4.618 -11.293 -1.566 1.00 29.49 ? 102 LYS A CG 1 ATOM 700 C CD . LYS A 1 85 ? 5.939 -10.584 -1.816 1.00 30.59 ? 102 LYS A CD 1 ATOM 701 C CE . LYS A 1 85 ? 6.584 -10.165 -0.507 1.00 32.43 ? 102 LYS A CE 1 ATOM 702 N NZ . LYS A 1 85 ? 8.016 -9.778 -0.693 1.00 33.03 ? 102 LYS A NZ 1 ATOM 703 N N . LEU A 1 86 ? 0.735 -12.177 -4.285 1.00 24.58 ? 103 LEU A N 1 ATOM 704 C CA . LEU A 1 86 ? -0.005 -12.448 -5.523 1.00 23.75 ? 103 LEU A CA 1 ATOM 705 C C . LEU A 1 86 ? 0.213 -11.439 -6.642 1.00 22.71 ? 103 LEU A C 1 ATOM 706 O O . LEU A 1 86 ? 0.033 -11.769 -7.811 1.00 22.33 ? 103 LEU A O 1 ATOM 707 C CB . LEU A 1 86 ? -1.499 -12.535 -5.221 1.00 24.28 ? 103 LEU A CB 1 ATOM 708 C CG . LEU A 1 86 ? -1.927 -13.767 -4.422 1.00 25.21 ? 103 LEU A CG 1 ATOM 709 C CD1 . LEU A 1 86 ? -3.381 -13.615 -4.021 1.00 25.47 ? 103 LEU A CD1 1 ATOM 710 C CD2 . LEU A 1 86 ? -1.713 -15.045 -5.222 1.00 25.96 ? 103 LEU A CD2 1 ATOM 711 N N . GLY A 1 87 ? 0.552 -10.200 -6.307 1.00 21.38 ? 104 GLY A N 1 ATOM 712 C CA . GLY A 1 87 ? 0.589 -9.151 -7.319 1.00 20.36 ? 104 GLY A CA 1 ATOM 713 C C . GLY A 1 87 ? -0.747 -9.025 -8.033 1.00 19.35 ? 104 GLY A C 1 ATOM 714 O O . GLY A 1 87 ? -1.809 -9.082 -7.404 1.00 19.59 ? 104 GLY A O 1 ATOM 715 N N . TYR A 1 88 ? -0.702 -8.917 -9.357 1.00 18.98 ? 105 TYR A N 1 ATOM 716 C CA . TYR A 1 88 ? -1.922 -8.784 -10.162 1.00 19.90 ? 105 TYR A CA 1 ATOM 717 C C . TYR A 1 88 ? -2.908 -9.950 -10.012 1.00 19.50 ? 105 TYR A C 1 ATOM 718 O O . TYR A 1 88 ? -4.123 -9.760 -10.150 1.00 18.47 ? 105 TYR A O 1 ATOM 719 C CB . TYR A 1 88 ? -1.572 -8.607 -11.639 1.00 20.12 ? 105 TYR A CB 1 ATOM 720 C CG . TYR A 1 88 ? -0.859 -7.318 -12.015 1.00 20.06 ? 105 TYR A CG 1 ATOM 721 C CD1 . TYR A 1 88 ? -0.901 -6.171 -11.206 1.00 20.02 ? 105 TYR A CD1 1 ATOM 722 C CD2 . TYR A 1 88 ? -0.170 -7.239 -13.222 1.00 20.48 ? 105 TYR A CD2 1 ATOM 723 C CE1 . TYR A 1 88 ? -0.257 -5.003 -11.585 1.00 19.96 ? 105 TYR A CE1 1 ATOM 724 C CE2 . TYR A 1 88 ? 0.464 -6.074 -13.613 1.00 20.67 ? 105 TYR A CE2 1 ATOM 725 C CZ . TYR A 1 88 ? 0.422 -4.961 -12.798 1.00 19.82 ? 105 TYR A CZ 1 ATOM 726 O OH . TYR A 1 88 ? 1.052 -3.811 -13.204 1.00 19.32 ? 105 TYR A OH 1 ATOM 727 N N . ALA A 1 89 ? -2.383 -11.133 -9.701 1.00 19.48 ? 106 ALA A N 1 ATOM 728 C CA . ALA A 1 89 ? -3.211 -12.325 -9.492 1.00 20.35 ? 106 ALA A CA 1 ATOM 729 C C . ALA A 1 89 ? -4.176 -12.201 -8.311 1.00 20.29 ? 106 ALA A C 1 ATOM 730 O O . ALA A 1 89 ? -5.096 -12.994 -8.202 1.00 21.67 ? 106 ALA A O 1 ATOM 731 C CB . ALA A 1 89 ? -2.331 -13.561 -9.336 1.00 20.42 ? 106 ALA A CB 1 ATOM 732 N N . ALA A 1 90 ? -3.983 -11.210 -7.442 1.00 20.34 ? 107 ALA A N 1 ATOM 733 C CA . ALA A 1 90 ? -4.959 -10.893 -6.397 1.00 20.62 ? 107 ALA A CA 1 ATOM 734 C C . ALA A 1 90 ? -6.285 -10.342 -6.913 1.00 20.97 ? 107 ALA A C 1 ATOM 735 O O . ALA A 1 90 ? -7.278 -10.388 -6.194 1.00 20.34 ? 107 ALA A O 1 ATOM 736 C CB . ALA A 1 90 ? -4.369 -9.905 -5.412 1.00 21.16 ? 107 ALA A CB 1 ATOM 737 N N . LEU A 1 91 ? -6.301 -9.796 -8.128 1.00 20.83 ? 108 LEU A N 1 ATOM 738 C CA . LEU A 1 91 ? -7.504 -9.200 -8.683 1.00 21.54 ? 108 LEU A CA 1 ATOM 739 C C . LEU A 1 91 ? -8.569 -10.265 -8.923 1.00 22.25 ? 108 LEU A C 1 ATOM 740 O O . LEU A 1 91 ? -8.232 -11.403 -9.241 1.00 21.30 ? 108 LEU A O 1 ATOM 741 C CB . LEU A 1 91 ? -7.211 -8.478 -10.006 1.00 21.05 ? 108 LEU A CB 1 ATOM 742 C CG . LEU A 1 91 ? -6.403 -7.177 -9.932 1.00 20.65 ? 108 LEU A CG 1 ATOM 743 C CD1 . LEU A 1 91 ? -5.904 -6.785 -11.310 1.00 20.35 ? 108 LEU A CD1 1 ATOM 744 C CD2 . LEU A 1 91 ? -7.235 -6.054 -9.335 1.00 21.02 ? 108 LEU A CD2 1 ATOM 745 N N . PRO A 1 92 ? -9.857 -9.899 -8.775 1.00 23.19 ? 109 PRO A N 1 ATOM 746 C CA . PRO A 1 92 ? -10.905 -10.812 -9.241 1.00 24.33 ? 109 PRO A CA 1 ATOM 747 C C . PRO A 1 92 ? -10.707 -11.173 -10.720 1.00 24.36 ? 109 PRO A C 1 ATOM 748 O O . PRO A 1 92 ? -10.168 -10.361 -11.495 1.00 22.10 ? 109 PRO A O 1 ATOM 749 C CB . PRO A 1 92 ? -12.199 -10.015 -9.040 1.00 24.25 ? 109 PRO A CB 1 ATOM 750 C CG . PRO A 1 92 ? -11.867 -8.943 -8.067 1.00 24.93 ? 109 PRO A CG 1 ATOM 751 C CD . PRO A 1 92 ? -10.412 -8.632 -8.268 1.00 24.74 ? 109 PRO A CD 1 ATOM 752 N N . GLU A 1 93 ? -11.123 -12.381 -11.101 1.00 25.53 ? 110 GLU A N 1 ATOM 753 C CA . GLU A 1 93 ? -10.853 -12.880 -12.450 1.00 26.60 ? 110 GLU A CA 1 ATOM 754 C C . GLU A 1 93 ? -11.291 -11.920 -13.572 1.00 25.47 ? 110 GLU A C 1 ATOM 755 O O . GLU A 1 93 ? -10.550 -11.747 -14.544 1.00 24.02 ? 110 GLU A O 1 ATOM 756 C CB . GLU A 1 93 ? -11.417 -14.298 -12.662 1.00 29.82 ? 110 GLU A CB 1 ATOM 757 C CG . GLU A 1 93 ? -12.925 -14.429 -12.674 1.00 33.58 ? 110 GLU A CG 1 ATOM 758 C CD . GLU A 1 93 ? -13.396 -15.882 -12.777 1.00 37.12 ? 110 GLU A CD 1 ATOM 759 O OE1 . GLU A 1 93 ? -12.658 -16.727 -13.335 1.00 38.08 ? 110 GLU A OE1 1 ATOM 760 O OE2 . GLU A 1 93 ? -14.517 -16.179 -12.297 1.00 41.30 ? 110 GLU A OE2 1 ATOM 761 N N . ASP A 1 94 ? -12.452 -11.280 -13.445 1.00 25.00 ? 111 ASP A N 1 ATOM 762 C CA . ASP A 1 94 ? -12.886 -10.327 -14.489 1.00 26.20 ? 111 ASP A CA 1 ATOM 763 C C . ASP A 1 94 ? -11.942 -9.114 -14.590 1.00 24.96 ? 111 ASP A C 1 ATOM 764 O O . ASP A 1 94 ? -11.574 -8.699 -15.694 1.00 23.64 ? 111 ASP A O 1 ATOM 765 C CB . ASP A 1 94 ? -14.369 -9.912 -14.346 1.00 29.10 ? 111 ASP A CB 1 ATOM 766 C CG . ASP A 1 94 ? -14.690 -9.177 -13.039 1.00 32.50 ? 111 ASP A CG 1 ATOM 767 O OD1 . ASP A 1 94 ? -13.886 -9.200 -12.077 1.00 36.21 ? 111 ASP A OD1 1 ATOM 768 O OD2 . ASP A 1 94 ? -15.787 -8.579 -12.968 1.00 35.64 ? 111 ASP A OD2 1 ATOM 769 N N . ASP A 1 95 ? -11.531 -8.575 -13.444 1.00 22.66 ? 112 ASP A N 1 ATOM 770 C CA . ASP A 1 95 ? -10.561 -7.470 -13.408 1.00 23.50 ? 112 ASP A CA 1 ATOM 771 C C . ASP A 1 95 ? -9.197 -7.876 -13.950 1.00 22.40 ? 112 ASP A C 1 ATOM 772 O O . ASP A 1 95 ? -8.547 -7.093 -14.645 1.00 21.10 ? 112 ASP A O 1 ATOM 773 C CB . ASP A 1 95 ? -10.370 -6.945 -11.982 1.00 24.99 ? 112 ASP A CB 1 ATOM 774 C CG . ASP A 1 95 ? -11.560 -6.167 -11.476 1.00 27.31 ? 112 ASP A CG 1 ATOM 775 O OD1 . ASP A 1 95 ? -12.378 -5.698 -12.282 1.00 28.13 ? 112 ASP A OD1 1 ATOM 776 O OD2 . ASP A 1 95 ? -11.650 -5.987 -10.248 1.00 31.43 ? 112 ASP A OD2 1 ATOM 777 N N . TYR A 1 96 ? -8.761 -9.094 -13.626 1.00 21.65 ? 113 TYR A N 1 ATOM 778 C CA . TYR A 1 96 ? -7.491 -9.598 -14.140 1.00 21.30 ? 113 TYR A CA 1 ATOM 779 C C . TYR A 1 96 ? -7.526 -9.701 -15.662 1.00 21.22 ? 113 TYR A C 1 ATOM 780 O O . TYR A 1 96 ? -6.593 -9.259 -16.336 1.00 20.31 ? 113 TYR A O 1 ATOM 781 C CB . TYR A 1 96 ? -7.121 -10.941 -13.510 1.00 21.37 ? 113 TYR A CB 1 ATOM 782 C CG . TYR A 1 96 ? -5.726 -11.371 -13.874 1.00 21.53 ? 113 TYR A CG 1 ATOM 783 C CD1 . TYR A 1 96 ? -4.621 -10.749 -13.310 1.00 22.33 ? 113 TYR A CD1 1 ATOM 784 C CD2 . TYR A 1 96 ? -5.504 -12.378 -14.795 1.00 21.24 ? 113 TYR A CD2 1 ATOM 785 C CE1 . TYR A 1 96 ? -3.330 -11.126 -13.650 1.00 23.36 ? 113 TYR A CE1 1 ATOM 786 C CE2 . TYR A 1 96 ? -4.217 -12.764 -15.141 1.00 21.43 ? 113 TYR A CE2 1 ATOM 787 C CZ . TYR A 1 96 ? -3.134 -12.137 -14.569 1.00 22.26 ? 113 TYR A CZ 1 ATOM 788 O OH . TYR A 1 96 ? -1.863 -12.512 -14.915 1.00 22.00 ? 113 TYR A OH 1 ATOM 789 N N . ALA A 1 97 ? -8.612 -10.256 -16.201 1.00 20.99 ? 114 ALA A N 1 ATOM 790 C CA . ALA A 1 97 ? -8.770 -10.371 -17.650 1.00 20.95 ? 114 ALA A CA 1 ATOM 791 C C . ALA A 1 97 ? -8.768 -8.985 -18.325 1.00 20.91 ? 114 ALA A C 1 ATOM 792 O O . ALA A 1 97 ? -8.151 -8.797 -19.376 1.00 20.21 ? 114 ALA A O 1 ATOM 793 C CB . ALA A 1 97 ? -10.046 -11.130 -17.995 1.00 21.18 ? 114 ALA A CB 1 ATOM 794 N N . GLU A 1 98 ? -9.445 -8.021 -17.711 1.00 19.83 ? 115 GLU A N 1 ATOM 795 C CA . GLU A 1 98 ? -9.481 -6.672 -18.244 1.00 21.02 ? 115 GLU A CA 1 ATOM 796 C C . GLU A 1 98 ? -8.087 -6.019 -18.220 1.00 19.96 ? 115 GLU A C 1 ATOM 797 O O . GLU A 1 98 ? -7.699 -5.355 -19.194 1.00 19.94 ? 115 GLU A O 1 ATOM 798 C CB . GLU A 1 98 ? -10.483 -5.810 -17.488 1.00 21.84 ? 115 GLU A CB 1 ATOM 799 C CG . GLU A 1 98 ? -10.662 -4.444 -18.129 1.00 23.20 ? 115 GLU A CG 1 ATOM 800 C CD . GLU A 1 98 ? -11.587 -3.526 -17.366 1.00 24.78 ? 115 GLU A CD 1 ATOM 801 O OE1 . GLU A 1 98 ? -12.084 -3.889 -16.277 1.00 26.33 ? 115 GLU A OE1 1 ATOM 802 O OE2 . GLU A 1 98 ? -11.801 -2.403 -17.857 1.00 25.93 ? 115 GLU A OE2 1 ATOM 803 N N . LEU A 1 99 ? -7.345 -6.209 -17.125 1.00 19.09 ? 116 LEU A N 1 ATOM 804 C CA . LEU A 1 99 ? -5.964 -5.715 -17.049 1.00 19.54 ? 116 LEU A CA 1 ATOM 805 C C . LEU A 1 99 ? -5.099 -6.326 -18.166 1.00 19.55 ? 116 LEU A C 1 ATOM 806 O O . LEU A 1 99 ? -4.399 -5.608 -18.859 1.00 18.71 ? 116 LEU A O 1 ATOM 807 C CB . LEU A 1 99 ? -5.352 -5.975 -15.675 1.00 19.85 ? 116 LEU A CB 1 ATOM 808 C CG . LEU A 1 99 ? -3.876 -5.608 -15.484 1.00 20.16 ? 116 LEU A CG 1 ATOM 809 C CD1 . LEU A 1 99 ? -3.623 -4.137 -15.769 1.00 20.25 ? 116 LEU A CD1 1 ATOM 810 C CD2 . LEU A 1 99 ? -3.436 -5.955 -14.071 1.00 20.90 ? 116 LEU A CD2 1 ATOM 811 N N . LEU A 1 100 ? -5.171 -7.644 -18.350 1.00 20.24 ? 117 LEU A N 1 ATOM 812 C CA . LEU A 1 100 ? -4.442 -8.304 -19.437 1.00 21.23 ? 117 LEU A CA 1 ATOM 813 C C . LEU A 1 100 ? -4.799 -7.719 -20.808 1.00 21.67 ? 117 LEU A C 1 ATOM 814 O O . LEU A 1 100 ? -3.918 -7.507 -21.634 1.00 21.09 ? 117 LEU A O 1 ATOM 815 C CB . LEU A 1 100 ? -4.744 -9.804 -19.465 1.00 22.09 ? 117 LEU A CB 1 ATOM 816 C CG . LEU A 1 100 ? -4.243 -10.661 -18.301 1.00 23.63 ? 117 LEU A CG 1 ATOM 817 C CD1 . LEU A 1 100 ? -4.896 -12.043 -18.368 1.00 24.75 ? 117 LEU A CD1 1 ATOM 818 C CD2 . LEU A 1 100 ? -2.726 -10.748 -18.311 1.00 23.94 ? 117 LEU A CD2 1 ATOM 819 N N . ASP A 1 101 ? -6.094 -7.510 -21.054 1.00 21.76 ? 118 ASP A N 1 ATOM 820 C CA . ASP A 1 101 ? -6.560 -6.899 -22.308 1.00 22.85 ? 118 ASP A CA 1 ATOM 821 C C . ASP A 1 101 ? -5.988 -5.491 -22.484 1.00 22.12 ? 118 ASP A C 1 ATOM 822 O O . ASP A 1 101 ? -5.584 -5.121 -23.575 1.00 20.69 ? 118 ASP A O 1 ATOM 823 C CB . ASP A 1 101 ? -8.098 -6.820 -22.366 1.00 24.85 ? 118 ASP A CB 1 ATOM 824 C CG . ASP A 1 101 ? -8.765 -8.174 -22.590 1.00 28.42 ? 118 ASP A CG 1 ATOM 825 O OD1 . ASP A 1 101 ? -8.119 -9.112 -23.094 1.00 30.68 ? 118 ASP A OD1 1 ATOM 826 O OD2 . ASP A 1 101 ? -9.966 -8.292 -22.267 1.00 33.75 ? 118 ASP A OD2 1 ATOM 827 N N . THR A 1 102 ? -5.959 -4.726 -21.396 1.00 21.54 ? 119 THR A N 1 ATOM 828 C CA . THR A 1 102 ? -5.450 -3.365 -21.414 1.00 21.98 ? 119 THR A CA 1 ATOM 829 C C . THR A 1 102 ? -3.952 -3.333 -21.761 1.00 21.67 ? 119 THR A C 1 ATOM 830 O O . THR A 1 102 ? -3.529 -2.563 -22.631 1.00 21.42 ? 119 THR A O 1 ATOM 831 C CB . THR A 1 102 ? -5.715 -2.687 -20.058 1.00 23.07 ? 119 THR A CB 1 ATOM 832 O OG1 . THR A 1 102 ? -7.126 -2.688 -19.793 1.00 23.95 ? 119 THR A OG1 1 ATOM 833 C CG2 . THR A 1 102 ? -5.230 -1.289 -20.045 1.00 23.50 ? 119 THR A CG2 1 ATOM 834 N N . LEU A 1 103 ? -3.177 -4.200 -21.107 1.00 20.61 ? 120 LEU A N 1 ATOM 835 C CA . LEU A 1 103 ? -1.740 -4.314 -21.363 1.00 21.47 ? 120 LEU A CA 1 ATOM 836 C C . LEU A 1 103 ? -1.448 -4.725 -22.811 1.00 21.79 ? 120 LEU A C 1 ATOM 837 O O . LEU A 1 103 ? -0.588 -4.121 -23.477 1.00 21.07 ? 120 LEU A O 1 ATOM 838 C CB . LEU A 1 103 ? -1.100 -5.294 -20.370 1.00 22.34 ? 120 LEU A CB 1 ATOM 839 C CG . LEU A 1 103 ? -1.084 -4.827 -18.906 1.00 22.54 ? 120 LEU A CG 1 ATOM 840 C CD1 . LEU A 1 103 ? -0.506 -5.915 -18.010 1.00 23.13 ? 120 LEU A CD1 1 ATOM 841 C CD2 . LEU A 1 103 ? -0.304 -3.530 -18.748 1.00 23.35 ? 120 LEU A CD2 1 ATOM 842 N N . SER A 1 104 ? -2.189 -5.716 -23.305 1.00 21.25 ? 121 SER A N 1 ATOM 843 C CA . SER A 1 104 ? -2.055 -6.156 -24.694 1.00 21.84 ? 121 SER A CA 1 ATOM 844 C C . SER A 1 104 ? -2.369 -5.045 -25.691 1.00 20.77 ? 121 SER A C 1 ATOM 845 O O . SER A 1 104 ? -1.678 -4.908 -26.703 1.00 20.65 ? 121 SER A O 1 ATOM 846 C CB . SER A 1 104 ? -2.961 -7.353 -24.987 1.00 22.63 ? 121 SER A CB 1 ATOM 847 O OG . SER A 1 104 ? -2.540 -8.458 -24.249 1.00 24.93 ? 121 SER A OG 1 ATOM 848 N N . ALA A 1 105 ? -3.413 -4.269 -25.412 1.00 20.77 ? 122 ALA A N 1 ATOM 849 C CA . ALA A 1 105 ? -3.779 -3.151 -26.274 1.00 20.85 ? 122 ALA A CA 1 ATOM 850 C C . ALA A 1 105 ? -2.641 -2.131 -26.369 1.00 20.71 ? 122 ALA A C 1 ATOM 851 O O . ALA A 1 105 ? -2.310 -1.667 -27.465 1.00 20.92 ? 122 ALA A O 1 ATOM 852 C CB . ALA A 1 105 ? -5.073 -2.495 -25.802 1.00 21.04 ? 122 ALA A CB 1 ATOM 853 N N . MET A 1 106 ? -2.013 -1.821 -25.238 1.00 20.19 ? 123 MET A N 1 ATOM 854 C CA . MET A 1 106 ? -0.904 -0.855 -25.226 1.00 21.01 ? 123 MET A CA 1 ATOM 855 C C . MET A 1 106 ? 0.347 -1.393 -25.919 1.00 21.22 ? 123 MET A C 1 ATOM 856 O O . MET A 1 106 ? 0.992 -0.667 -26.680 1.00 20.99 ? 123 MET A O 1 ATOM 857 C CB . MET A 1 106 ? -0.594 -0.405 -23.802 1.00 20.66 ? 123 MET A CB 1 ATOM 858 C CG . MET A 1 106 ? -1.748 0.357 -23.174 1.00 21.26 ? 123 MET A CG 1 ATOM 859 S SD . MET A 1 106 ? -1.276 1.268 -21.701 1.00 22.11 ? 123 MET A SD 1 ATOM 860 C CE . MET A 1 106 ? -0.809 -0.066 -20.602 1.00 22.05 ? 123 MET A CE 1 ATOM 861 N N . GLU A 1 107 ? 0.670 -2.662 -25.673 1.00 22.46 ? 124 GLU A N 1 ATOM 862 C CA . GLU A 1 107 ? 1.849 -3.298 -26.272 1.00 24.53 ? 124 GLU A CA 1 ATOM 863 C C . GLU A 1 107 ? 1.690 -3.453 -27.779 1.00 22.99 ? 124 GLU A C 1 ATOM 864 O O . GLU A 1 107 ? 2.608 -3.144 -28.541 1.00 21.22 ? 124 GLU A O 1 ATOM 865 C CB . GLU A 1 107 ? 2.128 -4.649 -25.612 1.00 27.85 ? 124 GLU A CB 1 ATOM 866 C CG . GLU A 1 107 ? 2.599 -4.510 -24.162 1.00 32.60 ? 124 GLU A CG 1 ATOM 867 C CD . GLU A 1 107 ? 2.508 -5.807 -23.362 1.00 37.28 ? 124 GLU A CD 1 ATOM 868 O OE1 . GLU A 1 107 ? 2.571 -6.896 -23.988 1.00 43.54 ? 124 GLU A OE1 1 ATOM 869 O OE2 . GLU A 1 107 ? 2.384 -5.735 -22.107 1.00 39.08 ? 124 GLU A OE2 1 ATOM 870 N N . SER A 1 108 ? 0.511 -3.903 -28.197 1.00 21.13 ? 125 SER A N 1 ATOM 871 C CA . SER A 1 108 ? 0.177 -3.996 -29.617 1.00 21.72 ? 125 SER A CA 1 ATOM 872 C C . SER A 1 108 ? 0.254 -2.630 -30.300 1.00 20.37 ? 125 SER A C 1 ATOM 873 O O . SER A 1 108 ? 0.828 -2.501 -31.389 1.00 19.77 ? 125 SER A O 1 ATOM 874 C CB . SER A 1 108 ? -1.233 -4.554 -29.802 1.00 22.93 ? 125 SER A CB 1 ATOM 875 O OG . SER A 1 108 ? -1.544 -4.645 -31.180 1.00 26.74 ? 125 SER A OG 1 ATOM 876 N N . ASN A 1 109 ? -0.327 -1.619 -29.653 1.00 19.26 ? 126 ASN A N 1 ATOM 877 C CA . ASN A 1 109 ? -0.280 -0.258 -30.174 1.00 19.03 ? 126 ASN A CA 1 ATOM 878 C C . ASN A 1 109 ? 1.145 0.189 -30.433 1.00 18.65 ? 126 ASN A C 1 ATOM 879 O O . ASN A 1 109 ? 1.473 0.628 -31.531 1.00 18.67 ? 126 ASN A O 1 ATOM 880 C CB . ASN A 1 109 ? -0.929 0.739 -29.224 1.00 19.63 ? 126 ASN A CB 1 ATOM 881 C CG . ASN A 1 109 ? -0.967 2.131 -29.814 1.00 19.72 ? 126 ASN A CG 1 ATOM 882 O OD1 . ASN A 1 109 ? -1.827 2.430 -30.633 1.00 20.22 ? 126 ASN A OD1 1 ATOM 883 N ND2 . ASN A 1 109 ? -0.008 2.972 -29.439 1.00 19.24 ? 126 ASN A ND2 1 ATOM 884 N N . PHE A 1 110 ? 1.983 0.062 -29.411 1.00 18.21 ? 127 PHE A N 1 ATOM 885 C CA . PHE A 1 110 ? 3.376 0.452 -29.520 1.00 18.36 ? 127 PHE A CA 1 ATOM 886 C C . PHE A 1 110 ? 4.056 -0.282 -30.678 1.00 19.47 ? 127 PHE A C 1 ATOM 887 O O . PHE A 1 110 ? 4.702 0.346 -31.520 1.00 19.66 ? 127 PHE A O 1 ATOM 888 C CB . PHE A 1 110 ? 4.113 0.201 -28.200 1.00 18.13 ? 127 PHE A CB 1 ATOM 889 C CG . PHE A 1 110 ? 5.498 0.768 -28.172 1.00 17.85 ? 127 PHE A CG 1 ATOM 890 C CD1 . PHE A 1 110 ? 6.579 0.014 -28.616 1.00 18.60 ? 127 PHE A CD1 1 ATOM 891 C CD2 . PHE A 1 110 ? 5.724 2.051 -27.708 1.00 18.19 ? 127 PHE A CD2 1 ATOM 892 C CE1 . PHE A 1 110 ? 7.860 0.543 -28.608 1.00 18.47 ? 127 PHE A CE1 1 ATOM 893 C CE2 . PHE A 1 110 ? 6.997 2.583 -27.682 1.00 17.74 ? 127 PHE A CE2 1 ATOM 894 C CZ . PHE A 1 110 ? 8.070 1.830 -28.138 1.00 18.47 ? 127 PHE A CZ 1 ATOM 895 N N . ALA A 1 111 ? 3.864 -1.601 -30.738 1.00 19.53 ? 128 ALA A N 1 ATOM 896 C CA . ALA A 1 111 ? 4.537 -2.438 -31.732 1.00 20.52 ? 128 ALA A CA 1 ATOM 897 C C . ALA A 1 111 ? 4.128 -2.125 -33.170 1.00 20.82 ? 128 ALA A C 1 ATOM 898 O O . ALA A 1 111 ? 4.935 -2.266 -34.075 1.00 21.47 ? 128 ALA A O 1 ATOM 899 C CB . ALA A 1 111 ? 4.278 -3.895 -31.436 1.00 21.27 ? 128 ALA A CB 1 ATOM 900 N N . LYS A 1 112 ? 2.884 -1.698 -33.357 1.00 20.57 ? 129 LYS A N 1 ATOM 901 C CA . LYS A 1 112 ? 2.311 -1.425 -34.678 1.00 21.39 ? 129 LYS A CA 1 ATOM 902 C C . LYS A 1 112 ? 2.451 0.026 -35.178 1.00 20.32 ? 129 LYS A C 1 ATOM 903 O O . LYS A 1 112 ? 2.027 0.323 -36.294 1.00 19.66 ? 129 LYS A O 1 ATOM 904 C CB . LYS A 1 112 ? 0.831 -1.820 -34.678 1.00 23.30 ? 129 LYS A CB 1 ATOM 905 C CG . LYS A 1 112 ? 0.591 -3.323 -34.550 1.00 25.73 ? 129 LYS A CG 1 ATOM 906 C CD . LYS A 1 112 ? -0.899 -3.635 -34.576 1.00 28.23 ? 129 LYS A CD 1 ATOM 907 C CE . LYS A 1 112 ? -1.140 -5.130 -34.669 1.00 30.23 ? 129 LYS A CE 1 ATOM 908 N NZ . LYS A 1 112 ? -2.582 -5.447 -34.853 1.00 32.30 ? 129 LYS A NZ 1 ATOM 909 N N . VAL A 1 113 ? 3.048 0.921 -34.392 1.00 19.20 ? 130 VAL A N 1 ATOM 910 C CA . VAL A 1 113 ? 3.215 2.312 -34.832 1.00 19.34 ? 130 VAL A CA 1 ATOM 911 C C . VAL A 1 113 ? 3.953 2.358 -36.169 1.00 19.31 ? 130 VAL A C 1 ATOM 912 O O . VAL A 1 113 ? 5.033 1.797 -36.300 1.00 18.64 ? 130 VAL A O 1 ATOM 913 C CB . VAL A 1 113 ? 3.968 3.184 -33.793 1.00 19.45 ? 130 VAL A CB 1 ATOM 914 C CG1 . VAL A 1 113 ? 4.323 4.565 -34.367 1.00 19.52 ? 130 VAL A CG1 1 ATOM 915 C CG2 . VAL A 1 113 ? 3.134 3.334 -32.529 1.00 19.48 ? 130 VAL A CG2 1 ATOM 916 N N . LYS A 1 114 ? 3.336 3.015 -37.148 1.00 19.94 ? 131 LYS A N 1 ATOM 917 C CA . LYS A 1 114 ? 3.963 3.321 -38.431 1.00 21.31 ? 131 LYS A CA 1 ATOM 918 C C . LYS A 1 114 ? 3.764 4.804 -38.699 1.00 20.47 ? 131 LYS A C 1 ATOM 919 O O . LYS A 1 114 ? 2.692 5.353 -38.389 1.00 20.26 ? 131 LYS A O 1 ATOM 920 C CB . LYS A 1 114 ? 3.325 2.510 -39.567 1.00 22.94 ? 131 LYS A CB 1 ATOM 921 C CG . LYS A 1 114 ? 3.541 1.007 -39.503 1.00 24.97 ? 131 LYS A CG 1 ATOM 922 C CD . LYS A 1 114 ? 5.023 0.659 -39.579 1.00 27.36 ? 131 LYS A CD 1 ATOM 923 C CE . LYS A 1 114 ? 5.281 -0.733 -40.153 1.00 30.35 ? 131 LYS A CE 1 ATOM 924 N NZ . LYS A 1 114 ? 5.028 -1.809 -39.159 1.00 30.35 ? 131 LYS A NZ 1 ATOM 925 N N . VAL A 1 115 ? 4.778 5.456 -39.265 1.00 19.64 ? 132 VAL A N 1 ATOM 926 C CA . VAL A 1 115 ? 4.665 6.873 -39.633 1.00 19.95 ? 132 VAL A CA 1 ATOM 927 C C . VAL A 1 115 ? 4.996 7.109 -41.100 1.00 20.02 ? 132 VAL A C 1 ATOM 928 O O . VAL A 1 115 ? 5.601 6.261 -41.750 1.00 19.80 ? 132 VAL A O 1 ATOM 929 C CB . VAL A 1 115 ? 5.552 7.807 -38.767 1.00 20.07 ? 132 VAL A CB 1 ATOM 930 C CG1 . VAL A 1 115 ? 5.266 7.593 -37.289 1.00 20.14 ? 132 VAL A CG1 1 ATOM 931 C CG2 . VAL A 1 115 ? 7.043 7.628 -39.066 1.00 20.41 ? 132 VAL A CG2 1 ATOM 932 N N . CYS A 1 116 ? 4.582 8.275 -41.594 1.00 20.45 ? 133 CYS A N 1 ATOM 933 C CA . CYS A 1 116 ? 4.842 8.685 -42.971 1.00 21.70 ? 133 CYS A CA 1 ATOM 934 C C . CYS A 1 116 ? 6.205 9.365 -43.085 1.00 20.83 ? 133 CYS A C 1 ATOM 935 O O . CYS A 1 116 ? 6.642 10.093 -42.187 1.00 20.23 ? 133 CYS A O 1 ATOM 936 C CB . CYS A 1 116 ? 3.716 9.584 -43.507 1.00 24.18 ? 133 CYS A CB 1 ATOM 937 S SG . CYS A 1 116 ? 2.073 8.796 -43.536 1.00 27.34 ? 133 CYS A SG 1 ATOM 938 N N . ASP A 1 117 ? 6.885 9.097 -44.194 1.00 20.67 ? 134 ASP A N 1 ATOM 939 C CA . ASP A 1 117 ? 8.176 9.693 -44.466 1.00 20.59 ? 134 ASP A CA 1 ATOM 940 C C . ASP A 1 117 ? 8.061 11.225 -44.614 1.00 20.77 ? 134 ASP A C 1 ATOM 941 O O . ASP A 1 117 ? 7.128 11.733 -45.236 1.00 21.70 ? 134 ASP A O 1 ATOM 942 C CB . ASP A 1 117 ? 8.786 9.070 -45.718 1.00 20.41 ? 134 ASP A CB 1 ATOM 943 C CG . ASP A 1 117 ? 10.227 9.464 -45.914 1.00 20.64 ? 134 ASP A CG 1 ATOM 944 O OD1 . ASP A 1 117 ? 11.089 8.822 -45.286 1.00 20.20 ? 134 ASP A OD1 1 ATOM 945 O OD2 . ASP A 1 117 ? 10.484 10.415 -46.689 1.00 20.07 ? 134 ASP A OD2 1 ATOM 946 N N . TYR A 1 118 ? 9.017 11.938 -44.036 1.00 20.14 ? 135 TYR A N 1 ATOM 947 C CA . TYR A 1 118 ? 9.088 13.402 -44.089 1.00 20.92 ? 135 TYR A CA 1 ATOM 948 C C . TYR A 1 118 ? 9.249 13.958 -45.508 1.00 21.99 ? 135 TYR A C 1 ATOM 949 O O . TYR A 1 118 ? 8.644 14.973 -45.860 1.00 20.64 ? 135 TYR A O 1 ATOM 950 C CB . TYR A 1 118 ? 10.281 13.851 -43.249 1.00 21.09 ? 135 TYR A CB 1 ATOM 951 C CG . TYR A 1 118 ? 10.543 15.340 -43.166 1.00 21.57 ? 135 TYR A CG 1 ATOM 952 C CD1 . TYR A 1 118 ? 9.617 16.207 -42.571 1.00 22.07 ? 135 TYR A CD1 1 ATOM 953 C CD2 . TYR A 1 118 ? 11.739 15.878 -43.639 1.00 22.77 ? 135 TYR A CD2 1 ATOM 954 C CE1 . TYR A 1 118 ? 9.872 17.570 -42.466 1.00 22.31 ? 135 TYR A CE1 1 ATOM 955 C CE2 . TYR A 1 118 ? 12.005 17.237 -43.542 1.00 23.43 ? 135 TYR A CE2 1 ATOM 956 C CZ . TYR A 1 118 ? 11.070 18.076 -42.950 1.00 23.52 ? 135 TYR A CZ 1 ATOM 957 O OH . TYR A 1 118 ? 11.351 19.418 -42.843 1.00 24.06 ? 135 TYR A OH 1 ATOM 958 N N . LYS A 1 119 ? 10.081 13.292 -46.304 1.00 22.87 ? 136 LYS A N 1 ATOM 959 C CA . LYS A 1 119 ? 10.405 13.747 -47.661 1.00 24.10 ? 136 LYS A CA 1 ATOM 960 C C . LYS A 1 119 ? 9.360 13.298 -48.688 1.00 25.44 ? 136 LYS A C 1 ATOM 961 O O . LYS A 1 119 ? 9.111 14.016 -49.657 1.00 26.71 ? 136 LYS A O 1 ATOM 962 C CB . LYS A 1 119 ? 11.819 13.295 -48.040 1.00 25.24 ? 136 LYS A CB 1 ATOM 963 C CG . LYS A 1 119 ? 12.869 13.831 -47.073 1.00 26.74 ? 136 LYS A CG 1 ATOM 964 C CD . LYS A 1 119 ? 14.253 13.273 -47.332 1.00 28.76 ? 136 LYS A CD 1 ATOM 965 C CE . LYS A 1 119 ? 15.245 13.541 -46.190 1.00 29.14 ? 136 LYS A CE 1 ATOM 966 N NZ . LYS A 1 119 ? 16.532 12.776 -46.358 1.00 27.91 ? 136 LYS A NZ 1 ATOM 967 N N . ASP A 1 120 ? 8.736 12.138 -48.476 1.00 24.69 ? 137 ASP A N 1 ATOM 968 C CA . ASP A 1 120 ? 7.610 11.692 -49.309 1.00 26.08 ? 137 ASP A CA 1 ATOM 969 C C . ASP A 1 120 ? 6.502 11.118 -48.429 1.00 25.94 ? 137 ASP A C 1 ATOM 970 O O . ASP A 1 120 ? 6.535 9.949 -48.052 1.00 23.60 ? 137 ASP A O 1 ATOM 971 C CB . ASP A 1 120 ? 8.065 10.655 -50.345 1.00 26.83 ? 137 ASP A CB 1 ATOM 972 C CG . ASP A 1 120 ? 6.948 10.254 -51.324 1.00 28.56 ? 137 ASP A CG 1 ATOM 973 O OD1 . ASP A 1 120 ? 5.748 10.469 -51.047 1.00 27.57 ? 137 ASP A OD1 1 ATOM 974 O OD2 . ASP A 1 120 ? 7.278 9.701 -52.390 1.00 29.98 ? 137 ASP A OD2 1 ATOM 975 N N . SER A 1 121 ? 5.494 11.938 -48.152 1.00 26.47 ? 138 SER A N 1 ATOM 976 C CA . SER A 1 121 ? 4.454 11.585 -47.195 1.00 27.87 ? 138 SER A CA 1 ATOM 977 C C . SER A 1 121 ? 3.494 10.486 -47.661 1.00 28.11 ? 138 SER A C 1 ATOM 978 O O . SER A 1 121 ? 2.615 10.115 -46.898 1.00 29.75 ? 138 SER A O 1 ATOM 979 C CB . SER A 1 121 ? 3.651 12.830 -46.808 1.00 28.69 ? 138 SER A CB 1 ATOM 980 O OG . SER A 1 121 ? 2.817 13.217 -47.876 1.00 31.63 ? 138 SER A OG 1 ATOM 981 N N . THR A 1 122 ? 3.646 9.976 -48.886 1.00 26.88 ? 139 THR A N 1 ATOM 982 C CA . THR A 1 122 ? 2.885 8.813 -49.341 1.00 26.38 ? 139 THR A CA 1 ATOM 983 C C . THR A 1 122 ? 3.465 7.490 -48.844 1.00 26.49 ? 139 THR A C 1 ATOM 984 O O . THR A 1 122 ? 2.777 6.468 -48.870 1.00 26.10 ? 139 THR A O 1 ATOM 985 C CB . THR A 1 122 ? 2.762 8.768 -50.882 1.00 27.13 ? 139 THR A CB 1 ATOM 986 O OG1 . THR A 1 122 ? 4.052 8.591 -51.484 1.00 26.43 ? 139 THR A OG1 1 ATOM 987 C CG2 . THR A 1 122 ? 2.128 10.051 -51.405 1.00 26.68 ? 139 THR A CG2 1 ATOM 988 N N . LYS A 1 123 ? 4.725 7.493 -48.403 1.00 25.73 ? 140 LYS A N 1 ATOM 989 C CA . LYS A 1 123 ? 5.345 6.287 -47.869 1.00 24.99 ? 140 LYS A CA 1 ATOM 990 C C . LYS A 1 123 ? 5.100 6.274 -46.366 1.00 24.67 ? 140 LYS A C 1 ATOM 991 O O . LYS A 1 123 ? 5.713 7.042 -45.636 1.00 23.50 ? 140 LYS A O 1 ATOM 992 C CB . LYS A 1 123 ? 6.842 6.260 -48.176 1.00 25.21 ? 140 LYS A CB 1 ATOM 993 C CG . LYS A 1 123 ? 7.526 4.987 -47.700 1.00 25.92 ? 140 LYS A CG 1 ATOM 994 C CD . LYS A 1 123 ? 9.007 4.982 -47.995 1.00 26.73 ? 140 LYS A CD 1 ATOM 995 C CE . LYS A 1 123 ? 9.725 3.870 -47.250 1.00 26.87 ? 140 LYS A CE 1 ATOM 996 N NZ . LYS A 1 123 ? 9.166 2.537 -47.563 1.00 28.14 ? 140 LYS A NZ 1 ATOM 997 N N . CYS A 1 124 ? 4.212 5.399 -45.907 1.00 25.12 ? 141 CYS A N 1 ATOM 998 C CA . CYS A 1 124 ? 3.726 5.456 -44.526 1.00 25.66 ? 141 CYS A CA 1 ATOM 999 C C . CYS A 1 124 ? 3.944 4.170 -43.760 1.00 24.71 ? 141 CYS A C 1 ATOM 1000 O O . CYS A 1 124 ? 3.148 3.819 -42.907 1.00 24.33 ? 141 CYS A O 1 ATOM 1001 C CB . CYS A 1 124 ? 2.257 5.888 -44.511 1.00 27.55 ? 141 CYS A CB 1 ATOM 1002 S SG . CYS A 1 124 ? 2.044 7.564 -45.157 1.00 31.51 ? 141 CYS A SG 1 ATOM 1003 N N . ASP A 1 125 ? 5.067 3.512 -44.026 1.00 23.10 ? 142 ASP A N 1 ATOM 1004 C CA . ASP A 1 125 ? 5.388 2.229 -43.402 1.00 22.72 ? 142 ASP A CA 1 ATOM 1005 C C . ASP A 1 125 ? 6.690 2.270 -42.594 1.00 21.22 ? 142 ASP A C 1 ATOM 1006 O O . ASP A 1 125 ? 7.350 1.240 -42.419 1.00 21.10 ? 142 ASP A O 1 ATOM 1007 C CB . ASP A 1 125 ? 5.427 1.128 -44.470 1.00 24.44 ? 142 ASP A CB 1 ATOM 1008 C CG . ASP A 1 125 ? 6.471 1.380 -45.548 1.00 26.03 ? 142 ASP A CG 1 ATOM 1009 O OD1 . ASP A 1 125 ? 7.060 2.488 -45.614 1.00 26.90 ? 142 ASP A OD1 1 ATOM 1010 O OD2 . ASP A 1 125 ? 6.703 0.463 -46.347 1.00 28.61 ? 142 ASP A OD2 1 ATOM 1011 N N . LEU A 1 126 ? 7.052 3.448 -42.086 1.00 19.75 ? 143 LEU A N 1 ATOM 1012 C CA . LEU A 1 126 ? 8.268 3.588 -41.295 1.00 19.46 ? 143 LEU A CA 1 ATOM 1013 C C . LEU A 1 126 ? 7.962 3.193 -39.866 1.00 20.17 ? 143 LEU A C 1 ATOM 1014 O O . LEU A 1 126 ? 7.063 3.764 -39.256 1.00 20.42 ? 143 LEU A O 1 ATOM 1015 C CB . LEU A 1 126 ? 8.801 5.014 -41.328 1.00 19.37 ? 143 LEU A CB 1 ATOM 1016 C CG . LEU A 1 126 ? 9.558 5.457 -42.575 1.00 20.21 ? 143 LEU A CG 1 ATOM 1017 C CD1 . LEU A 1 126 ? 8.689 5.464 -43.827 1.00 20.70 ? 143 LEU A CD1 1 ATOM 1018 C CD2 . LEU A 1 126 ? 10.131 6.843 -42.331 1.00 20.35 ? 143 LEU A CD2 1 ATOM 1019 N N . ALA A 1 127 ? 8.718 2.233 -39.336 1.00 20.20 ? 144 ALA A N 1 ATOM 1020 C CA . ALA A 1 127 ? 8.551 1.781 -37.955 1.00 20.85 ? 144 ALA A CA 1 ATOM 1021 C C . ALA A 1 127 ? 9.592 2.451 -37.085 1.00 20.22 ? 144 ALA A C 1 ATOM 1022 O O . ALA A 1 127 ? 10.584 2.957 -37.594 1.00 20.55 ? 144 ALA A O 1 ATOM 1023 C CB . ALA A 1 127 ? 8.702 0.272 -37.882 1.00 21.39 ? 144 ALA A CB 1 ATOM 1024 N N . LEU A 1 128 ? 9.377 2.440 -35.770 1.00 19.80 ? 145 LEU A N 1 ATOM 1025 C CA . LEU A 1 128 ? 10.382 2.941 -34.841 1.00 19.84 ? 145 LEU A CA 1 ATOM 1026 C C . LEU A 1 128 ? 11.718 2.234 -35.083 1.00 20.25 ? 145 LEU A C 1 ATOM 1027 O O . LEU A 1 128 ? 12.747 2.872 -35.298 1.00 19.76 ? 145 LEU A O 1 ATOM 1028 C CB . LEU A 1 128 ? 9.944 2.732 -33.401 1.00 19.77 ? 145 LEU A CB 1 ATOM 1029 C CG . LEU A 1 128 ? 10.905 3.215 -32.311 1.00 20.08 ? 145 LEU A CG 1 ATOM 1030 C CD1 . LEU A 1 128 ? 11.099 4.714 -32.346 1.00 20.33 ? 145 LEU A CD1 1 ATOM 1031 C CD2 . LEU A 1 128 ? 10.388 2.780 -30.949 1.00 19.99 ? 145 LEU A CD2 1 ATOM 1032 N N . ASP A 1 129 ? 11.682 0.910 -35.057 1.00 20.31 ? 146 ASP A N 1 ATOM 1033 C CA . ASP A 1 129 ? 12.876 0.110 -35.264 1.00 21.38 ? 146 ASP A CA 1 ATOM 1034 C C . ASP A 1 129 ? 12.761 -0.543 -36.647 1.00 21.01 ? 146 ASP A C 1 ATOM 1035 O O . ASP A 1 129 ? 11.904 -1.404 -36.810 1.00 21.33 ? 146 ASP A O 1 ATOM 1036 C CB . ASP A 1 129 ? 12.966 -0.950 -34.161 1.00 22.43 ? 146 ASP A CB 1 ATOM 1037 C CG . ASP A 1 129 ? 14.271 -1.732 -34.199 1.00 24.25 ? 146 ASP A CG 1 ATOM 1038 O OD1 . ASP A 1 129 ? 14.981 -1.663 -35.211 1.00 26.41 ? 146 ASP A OD1 1 ATOM 1039 O OD2 . ASP A 1 129 ? 14.589 -2.421 -33.211 1.00 25.34 ? 146 ASP A OD2 1 ATOM 1040 N N . PRO A 1 130 ? 13.594 -0.196 -37.644 1.00 21.37 ? 147 PRO A N 1 ATOM 1041 C CA . PRO A 1 130 ? 14.763 0.674 -37.542 1.00 21.14 ? 147 PRO A CA 1 ATOM 1042 C C . PRO A 1 130 ? 14.591 2.105 -38.069 1.00 20.61 ? 147 PRO A C 1 ATOM 1043 O O . PRO A 1 130 ? 15.443 2.944 -37.798 1.00 19.96 ? 147 PRO A O 1 ATOM 1044 C CB . PRO A 1 130 ? 15.766 -0.037 -38.455 1.00 21.71 ? 147 PRO A CB 1 ATOM 1045 C CG . PRO A 1 130 ? 14.912 -0.573 -39.557 1.00 21.70 ? 147 PRO A CG 1 ATOM 1046 C CD . PRO A 1 130 ? 13.620 -0.983 -38.895 1.00 21.66 ? 147 PRO A CD 1 ATOM 1047 N N . GLU A 1 131 ? 13.532 2.383 -38.823 1.00 20.02 ? 148 GLU A N 1 ATOM 1048 C CA . GLU A 1 131 ? 13.517 3.585 -39.663 1.00 20.33 ? 148 GLU A CA 1 ATOM 1049 C C . GLU A 1 131 ? 13.496 4.892 -38.876 1.00 19.19 ? 148 GLU A C 1 ATOM 1050 O O . GLU A 1 131 ? 14.263 5.796 -39.167 1.00 18.68 ? 148 GLU A O 1 ATOM 1051 C CB . GLU A 1 131 ? 12.347 3.574 -40.653 1.00 21.11 ? 148 GLU A CB 1 ATOM 1052 C CG . GLU A 1 131 ? 12.450 2.531 -41.761 1.00 22.62 ? 148 GLU A CG 1 ATOM 1053 C CD . GLU A 1 131 ? 11.901 1.161 -41.377 1.00 24.76 ? 148 GLU A CD 1 ATOM 1054 O OE1 . GLU A 1 131 ? 11.099 1.060 -40.421 1.00 23.74 ? 148 GLU A OE1 1 ATOM 1055 O OE2 . GLU A 1 131 ? 12.281 0.168 -42.038 1.00 27.23 ? 148 GLU A OE2 1 ATOM 1056 N N . ILE A 1 132 ? 12.621 5.007 -37.884 1.00 18.67 ? 149 ILE A N 1 ATOM 1057 C CA . ILE A 1 132 ? 12.498 6.283 -37.188 1.00 18.60 ? 149 ILE A CA 1 ATOM 1058 C C . ILE A 1 132 ? 13.718 6.489 -36.295 1.00 19.45 ? 149 ILE A C 1 ATOM 1059 O O . ILE A 1 132 ? 14.277 7.586 -36.267 1.00 19.37 ? 149 ILE A O 1 ATOM 1060 C CB . ILE A 1 132 ? 11.186 6.432 -36.381 1.00 18.16 ? 149 ILE A CB 1 ATOM 1061 C CG1 . ILE A 1 132 ? 9.953 6.238 -37.293 1.00 17.97 ? 149 ILE A CG1 1 ATOM 1062 C CG2 . ILE A 1 132 ? 11.135 7.814 -35.741 1.00 18.36 ? 149 ILE A CG2 1 ATOM 1063 C CD1 . ILE A 1 132 ? 8.662 6.008 -36.532 1.00 17.92 ? 149 ILE A CD1 1 ATOM 1064 N N . GLU A 1 133 ? 14.138 5.435 -35.597 1.00 20.26 ? 150 GLU A N 1 ATOM 1065 C CA . GLU A 1 133 ? 15.372 5.484 -34.802 1.00 22.23 ? 150 GLU A CA 1 ATOM 1066 C C . GLU A 1 133 ? 16.602 5.899 -35.621 1.00 21.83 ? 150 GLU A C 1 ATOM 1067 O O . GLU A 1 133 ? 17.434 6.644 -35.115 1.00 19.82 ? 150 GLU A O 1 ATOM 1068 C CB . GLU A 1 133 ? 15.623 4.158 -34.076 1.00 24.59 ? 150 GLU A CB 1 ATOM 1069 C CG . GLU A 1 133 ? 14.705 3.999 -32.868 1.00 28.73 ? 150 GLU A CG 1 ATOM 1070 C CD . GLU A 1 133 ? 14.776 2.644 -32.180 1.00 33.25 ? 150 GLU A CD 1 ATOM 1071 O OE1 . GLU A 1 133 ? 15.372 1.687 -32.729 1.00 35.92 ? 150 GLU A OE1 1 ATOM 1072 O OE2 . GLU A 1 133 ? 14.200 2.533 -31.070 1.00 37.05 ? 150 GLU A OE2 1 ATOM 1073 N N . GLU A 1 134 ? 16.699 5.442 -36.873 1.00 21.95 ? 151 GLU A N 1 ATOM 1074 C CA . GLU A 1 134 ? 17.782 5.880 -37.764 1.00 23.54 ? 151 GLU A CA 1 ATOM 1075 C C . GLU A 1 134 ? 17.762 7.394 -37.974 1.00 21.91 ? 151 GLU A C 1 ATOM 1076 O O . GLU A 1 134 ? 18.819 8.042 -37.897 1.00 21.87 ? 151 GLU A O 1 ATOM 1077 C CB . GLU A 1 134 ? 17.731 5.173 -39.131 1.00 25.69 ? 151 GLU A CB 1 ATOM 1078 C CG . GLU A 1 134 ? 18.836 5.581 -40.124 1.00 29.99 ? 151 GLU A CG 1 ATOM 1079 C CD . GLU A 1 134 ? 18.609 6.914 -40.875 1.00 33.07 ? 151 GLU A CD 1 ATOM 1080 O OE1 . GLU A 1 134 ? 17.493 7.203 -41.363 1.00 35.05 ? 151 GLU A OE1 1 ATOM 1081 O OE2 . GLU A 1 134 ? 19.580 7.691 -41.001 1.00 37.25 ? 151 GLU A OE2 1 ATOM 1082 N N . VAL A 1 135 ? 16.580 7.957 -38.231 1.00 20.31 ? 152 VAL A N 1 ATOM 1083 C CA . VAL A 1 135 ? 16.480 9.393 -38.512 1.00 20.10 ? 152 VAL A CA 1 ATOM 1084 C C . VAL A 1 135 ? 16.850 10.199 -37.271 1.00 19.59 ? 152 VAL A C 1 ATOM 1085 O O . VAL A 1 135 ? 17.636 11.143 -37.353 1.00 19.05 ? 152 VAL A O 1 ATOM 1086 C CB . VAL A 1 135 ? 15.085 9.846 -38.996 1.00 20.95 ? 152 VAL A CB 1 ATOM 1087 C CG1 . VAL A 1 135 ? 15.081 11.352 -39.265 1.00 21.93 ? 152 VAL A CG1 1 ATOM 1088 C CG2 . VAL A 1 135 ? 14.691 9.118 -40.260 1.00 21.87 ? 152 VAL A CG2 1 ATOM 1089 N N . ILE A 1 136 ? 16.287 9.824 -36.125 1.00 19.85 ? 153 ILE A N 1 ATOM 1090 C CA . ILE A 1 136 ? 16.522 10.568 -34.887 1.00 20.30 ? 153 ILE A CA 1 ATOM 1091 C C . ILE A 1 136 ? 17.997 10.471 -34.499 1.00 20.20 ? 153 ILE A C 1 ATOM 1092 O O . ILE A 1 136 ? 18.555 11.427 -33.992 1.00 20.56 ? 153 ILE A O 1 ATOM 1093 C CB . ILE A 1 136 ? 15.634 10.076 -33.717 1.00 21.59 ? 153 ILE A CB 1 ATOM 1094 C CG1 . ILE A 1 136 ? 14.137 10.251 -34.023 1.00 21.92 ? 153 ILE A CG1 1 ATOM 1095 C CG2 . ILE A 1 136 ? 15.991 10.795 -32.415 1.00 22.79 ? 153 ILE A CG2 1 ATOM 1096 C CD1 . ILE A 1 136 ? 13.655 11.683 -34.141 1.00 22.25 ? 153 ILE A CD1 1 ATOM 1097 N N . SER A 1 137 ? 18.634 9.332 -34.754 1.00 20.32 ? 154 SER A N 1 ATOM 1098 C CA . SER A 1 137 ? 20.040 9.177 -34.399 1.00 21.09 ? 154 SER A CA 1 ATOM 1099 C C . SER A 1 137 ? 21.003 9.908 -35.353 1.00 21.06 ? 154 SER A C 1 ATOM 1100 O O . SER A 1 137 ? 22.034 10.386 -34.893 1.00 20.59 ? 154 SER A O 1 ATOM 1101 C CB . SER A 1 137 ? 20.411 7.693 -34.258 1.00 22.11 ? 154 SER A CB 1 ATOM 1102 O OG . SER A 1 137 ? 20.437 7.063 -35.508 1.00 25.17 ? 154 SER A OG 1 ATOM 1103 N N . LYS A 1 138 ? 20.660 10.023 -36.640 1.00 21.16 ? 155 LYS A N 1 ATOM 1104 C CA . LYS A 1 138 ? 21.604 10.519 -37.660 1.00 22.70 ? 155 LYS A CA 1 ATOM 1105 C C . LYS A 1 138 ? 21.281 11.857 -38.326 1.00 22.14 ? 155 LYS A C 1 ATOM 1106 O O . LYS A 1 138 ? 22.204 12.553 -38.746 1.00 21.38 ? 155 LYS A O 1 ATOM 1107 C CB . LYS A 1 138 ? 21.803 9.473 -38.759 1.00 24.16 ? 155 LYS A CB 1 ATOM 1108 C CG . LYS A 1 138 ? 22.271 8.104 -38.294 1.00 27.18 ? 155 LYS A CG 1 ATOM 1109 C CD . LYS A 1 138 ? 23.523 8.148 -37.432 1.00 29.86 ? 155 LYS A CD 1 ATOM 1110 C CE . LYS A 1 138 ? 23.853 6.780 -36.847 1.00 32.25 ? 155 LYS A CE 1 ATOM 1111 N NZ . LYS A 1 138 ? 24.587 5.929 -37.816 1.00 35.43 ? 155 LYS A NZ 1 ATOM 1112 N N . SER A 1 139 ? 20.007 12.217 -38.449 1.00 20.78 ? 156 SER A N 1 ATOM 1113 C CA . SER A 1 139 ? 19.651 13.475 -39.116 1.00 20.66 ? 156 SER A CA 1 ATOM 1114 C C . SER A 1 139 ? 20.034 14.674 -38.260 1.00 20.79 ? 156 SER A C 1 ATOM 1115 O O . SER A 1 139 ? 19.871 14.646 -37.044 1.00 20.86 ? 156 SER A O 1 ATOM 1116 C CB . SER A 1 139 ? 18.158 13.532 -39.438 1.00 20.29 ? 156 SER A CB 1 ATOM 1117 O OG . SER A 1 139 ? 17.793 14.804 -39.949 1.00 20.76 ? 156 SER A OG 1 ATOM 1118 N N . ARG A 1 140 ? 20.546 15.724 -38.902 1.00 20.69 ? 157 ARG A N 1 ATOM 1119 C CA . ARG A 1 140 ? 20.803 16.996 -38.226 1.00 20.88 ? 157 ARG A CA 1 ATOM 1120 C C . ARG A 1 140 ? 19.934 18.103 -38.811 1.00 20.41 ? 157 ARG A C 1 ATOM 1121 O O . ARG A 1 140 ? 20.284 19.282 -38.748 1.00 20.77 ? 157 ARG A O 1 ATOM 1122 C CB . ARG A 1 140 ? 22.295 17.353 -38.290 1.00 21.40 ? 157 ARG A CB 1 ATOM 1123 C CG . ARG A 1 140 ? 23.234 16.219 -37.881 1.00 22.10 ? 157 ARG A CG 1 ATOM 1124 C CD . ARG A 1 140 ? 23.068 15.795 -36.435 1.00 22.74 ? 157 ARG A CD 1 ATOM 1125 N NE . ARG A 1 140 ? 24.031 14.757 -36.049 1.00 23.42 ? 157 ARG A NE 1 ATOM 1126 C CZ . ARG A 1 140 ? 23.753 13.596 -35.446 1.00 24.61 ? 157 ARG A CZ 1 ATOM 1127 N NH1 . ARG A 1 140 ? 22.510 13.249 -35.111 1.00 24.13 ? 157 ARG A NH1 1 ATOM 1128 N NH2 . ARG A 1 140 ? 24.750 12.759 -35.160 1.00 26.09 ? 157 ARG A NH2 1 ATOM 1129 N N . ASP A 1 141 ? 18.780 17.715 -39.346 1.00 20.05 ? 158 ASP A N 1 ATOM 1130 C CA . ASP A 1 141 ? 17.788 18.640 -39.850 1.00 19.91 ? 158 ASP A CA 1 ATOM 1131 C C . ASP A 1 141 ? 16.771 18.808 -38.731 1.00 19.81 ? 158 ASP A C 1 ATOM 1132 O O . ASP A 1 141 ? 15.962 17.915 -38.499 1.00 18.40 ? 158 ASP A O 1 ATOM 1133 C CB . ASP A 1 141 ? 17.148 18.054 -41.104 1.00 20.95 ? 158 ASP A CB 1 ATOM 1134 C CG . ASP A 1 141 ? 16.066 18.925 -41.682 1.00 20.98 ? 158 ASP A CG 1 ATOM 1135 O OD1 . ASP A 1 141 ? 15.483 19.747 -40.963 1.00 21.74 ? 158 ASP A OD1 1 ATOM 1136 O OD2 . ASP A 1 141 ? 15.783 18.771 -42.878 1.00 21.63 ? 158 ASP A OD2 1 ATOM 1137 N N . HIS A 1 142 ? 16.802 19.945 -38.038 1.00 19.85 ? 159 HIS A N 1 ATOM 1138 C CA . HIS A 1 142 ? 15.943 20.107 -36.851 1.00 20.57 ? 159 HIS A CA 1 ATOM 1139 C C . HIS A 1 142 ? 14.436 20.022 -37.152 1.00 19.98 ? 159 HIS A C 1 ATOM 1140 O O . HIS A 1 142 ? 13.671 19.551 -36.312 1.00 19.54 ? 159 HIS A O 1 ATOM 1141 C CB . HIS A 1 142 ? 16.295 21.370 -36.052 1.00 21.36 ? 159 HIS A CB 1 ATOM 1142 C CG . HIS A 1 142 ? 15.953 22.657 -36.738 1.00 22.57 ? 159 HIS A CG 1 ATOM 1143 N ND1 . HIS A 1 142 ? 14.760 23.311 -36.534 1.00 23.06 ? 159 HIS A ND1 1 ATOM 1144 C CD2 . HIS A 1 142 ? 16.664 23.429 -37.595 1.00 23.22 ? 159 HIS A CD2 1 ATOM 1145 C CE1 . HIS A 1 142 ? 14.742 24.422 -37.253 1.00 23.62 ? 159 HIS A CE1 1 ATOM 1146 N NE2 . HIS A 1 142 ? 15.882 24.511 -37.911 1.00 23.15 ? 159 HIS A NE2 1 ATOM 1147 N N . GLU A 1 143 ? 14.017 20.428 -38.349 1.00 20.12 ? 160 GLU A N 1 ATOM 1148 C CA . GLU A 1 143 ? 12.595 20.325 -38.729 1.00 22.22 ? 160 GLU A CA 1 ATOM 1149 C C . GLU A 1 143 ? 12.196 18.880 -39.011 1.00 19.93 ? 160 GLU A C 1 ATOM 1150 O O . GLU A 1 143 ? 11.106 18.444 -38.644 1.00 18.53 ? 160 GLU A O 1 ATOM 1151 C CB . GLU A 1 143 ? 12.282 21.189 -39.954 1.00 25.39 ? 160 GLU A CB 1 ATOM 1152 C CG . GLU A 1 143 ? 12.574 22.676 -39.767 1.00 30.19 ? 160 GLU A CG 1 ATOM 1153 C CD . GLU A 1 143 ? 11.613 23.387 -38.828 1.00 34.72 ? 160 GLU A CD 1 ATOM 1154 O OE1 . GLU A 1 143 ? 10.639 22.772 -38.330 1.00 37.59 ? 160 GLU A OE1 1 ATOM 1155 O OE2 . GLU A 1 143 ? 11.836 24.598 -38.591 1.00 42.94 ? 160 GLU A OE2 1 ATOM 1156 N N . GLU A 1 144 ? 13.075 18.137 -39.676 1.00 18.13 ? 161 GLU A N 1 ATOM 1157 C CA . GLU A 1 144 ? 12.841 16.706 -39.907 1.00 17.56 ? 161 GLU A CA 1 ATOM 1158 C C . GLU A 1 144 ? 12.740 15.968 -38.577 1.00 16.85 ? 161 GLU A C 1 ATOM 1159 O O . GLU A 1 144 ? 11.853 15.135 -38.381 1.00 17.07 ? 161 GLU A O 1 ATOM 1160 C CB . GLU A 1 144 ? 13.988 16.094 -40.718 1.00 18.09 ? 161 GLU A CB 1 ATOM 1161 C CG . GLU A 1 144 ? 13.791 14.623 -41.053 1.00 18.48 ? 161 GLU A CG 1 ATOM 1162 C CD . GLU A 1 144 ? 14.902 14.056 -41.921 1.00 19.32 ? 161 GLU A CD 1 ATOM 1163 O OE1 . GLU A 1 144 ? 16.040 14.549 -41.857 1.00 19.44 ? 161 GLU A OE1 1 ATOM 1164 O OE2 . GLU A 1 144 ? 14.630 13.076 -42.625 1.00 20.15 ? 161 GLU A OE2 1 ATOM 1165 N N . LEU A 1 145 ? 13.672 16.270 -37.674 1.00 16.80 ? 162 LEU A N 1 ATOM 1166 C CA . LEU A 1 145 ? 13.693 15.648 -36.354 1.00 16.82 ? 162 LEU A CA 1 ATOM 1167 C C . LEU A 1 145 ? 12.390 15.926 -35.596 1.00 16.42 ? 162 LEU A C 1 ATOM 1168 O O . LEU A 1 145 ? 11.825 15.019 -34.980 1.00 16.18 ? 162 LEU A O 1 ATOM 1169 C CB . LEU A 1 145 ? 14.910 16.137 -35.561 1.00 16.71 ? 162 LEU A CB 1 ATOM 1170 C CG . LEU A 1 145 ? 16.265 15.667 -36.105 1.00 16.83 ? 162 LEU A CG 1 ATOM 1171 C CD1 . LEU A 1 145 ? 17.384 16.488 -35.487 1.00 17.48 ? 162 LEU A CD1 1 ATOM 1172 C CD2 . LEU A 1 145 ? 16.461 14.184 -35.860 1.00 16.96 ? 162 LEU A CD2 1 ATOM 1173 N N . ALA A 1 146 ? 11.904 17.169 -35.667 1.00 16.50 ? 163 ALA A N 1 ATOM 1174 C CA . ALA A 1 146 ? 10.676 17.573 -34.955 1.00 16.90 ? 163 ALA A CA 1 ATOM 1175 C C . ALA A 1 146 ? 9.435 16.897 -35.528 1.00 16.92 ? 163 ALA A C 1 ATOM 1176 O O . ALA A 1 146 ? 8.510 16.561 -34.795 1.00 16.70 ? 163 ALA A O 1 ATOM 1177 C CB . ALA A 1 146 ? 10.514 19.086 -34.987 1.00 17.78 ? 163 ALA A CB 1 ATOM 1178 N N . TYR A 1 147 ? 9.430 16.706 -36.843 1.00 17.17 ? 164 TYR A N 1 ATOM 1179 C CA . TYR A 1 147 ? 8.357 16.022 -37.531 1.00 17.96 ? 164 TYR A CA 1 ATOM 1180 C C . TYR A 1 147 ? 8.223 14.577 -37.025 1.00 17.21 ? 164 TYR A C 1 ATOM 1181 O O . TYR A 1 147 ? 7.139 14.157 -36.618 1.00 17.13 ? 164 TYR A O 1 ATOM 1182 C CB . TYR A 1 147 ? 8.569 16.072 -39.058 1.00 19.22 ? 164 TYR A CB 1 ATOM 1183 C CG . TYR A 1 147 ? 7.676 15.121 -39.796 1.00 20.75 ? 164 TYR A CG 1 ATOM 1184 C CD1 . TYR A 1 147 ? 6.371 15.481 -40.150 1.00 22.24 ? 164 TYR A CD1 1 ATOM 1185 C CD2 . TYR A 1 147 ? 8.121 13.840 -40.120 1.00 21.76 ? 164 TYR A CD2 1 ATOM 1186 C CE1 . TYR A 1 147 ? 5.541 14.582 -40.818 1.00 23.15 ? 164 TYR A CE1 1 ATOM 1187 C CE2 . TYR A 1 147 ? 7.310 12.942 -40.774 1.00 22.57 ? 164 TYR A CE2 1 ATOM 1188 C CZ . TYR A 1 147 ? 6.023 13.313 -41.128 1.00 24.15 ? 164 TYR A CZ 1 ATOM 1189 O OH . TYR A 1 147 ? 5.231 12.386 -41.762 1.00 25.18 ? 164 TYR A OH 1 ATOM 1190 N N . TYR A 1 148 ? 9.323 13.825 -37.041 1.00 16.64 ? 165 TYR A N 1 ATOM 1191 C CA . TYR A 1 148 ? 9.301 12.431 -36.570 1.00 17.01 ? 165 TYR A CA 1 ATOM 1192 C C . TYR A 1 148 ? 8.975 12.312 -35.084 1.00 16.80 ? 165 TYR A C 1 ATOM 1193 O O . TYR A 1 148 ? 8.214 11.412 -34.690 1.00 17.11 ? 165 TYR A O 1 ATOM 1194 C CB . TYR A 1 148 ? 10.612 11.698 -36.904 1.00 17.26 ? 165 TYR A CB 1 ATOM 1195 C CG . TYR A 1 148 ? 10.687 11.316 -38.358 1.00 17.48 ? 165 TYR A CG 1 ATOM 1196 C CD1 . TYR A 1 148 ? 9.843 10.331 -38.881 1.00 18.48 ? 165 TYR A CD1 1 ATOM 1197 C CD2 . TYR A 1 148 ? 11.567 11.953 -39.226 1.00 17.87 ? 165 TYR A CD2 1 ATOM 1198 C CE1 . TYR A 1 148 ? 9.891 9.986 -40.221 1.00 17.94 ? 165 TYR A CE1 1 ATOM 1199 C CE2 . TYR A 1 148 ? 11.626 11.614 -40.566 1.00 17.74 ? 165 TYR A CE2 1 ATOM 1200 C CZ . TYR A 1 148 ? 10.788 10.638 -41.058 1.00 18.38 ? 165 TYR A CZ 1 ATOM 1201 O OH . TYR A 1 148 ? 10.843 10.311 -42.397 1.00 18.31 ? 165 TYR A OH 1 ATOM 1202 N N . TRP A 1 149 ? 9.523 13.222 -34.279 1.00 16.08 ? 166 TRP A N 1 ATOM 1203 C CA . TRP A 1 149 ? 9.193 13.288 -32.847 1.00 16.22 ? 166 TRP A CA 1 ATOM 1204 C C . TRP A 1 149 ? 7.682 13.374 -32.670 1.00 16.15 ? 166 TRP A C 1 ATOM 1205 O O . TRP A 1 149 ? 7.087 12.561 -31.963 1.00 16.34 ? 166 TRP A O 1 ATOM 1206 C CB . TRP A 1 149 ? 9.875 14.484 -32.169 1.00 15.55 ? 166 TRP A CB 1 ATOM 1207 C CG . TRP A 1 149 ? 9.774 14.464 -30.678 1.00 15.83 ? 166 TRP A CG 1 ATOM 1208 C CD1 . TRP A 1 149 ? 10.733 14.057 -29.804 1.00 16.23 ? 166 TRP A CD1 1 ATOM 1209 C CD2 . TRP A 1 149 ? 8.648 14.866 -29.880 1.00 15.86 ? 166 TRP A CD2 1 ATOM 1210 N NE1 . TRP A 1 149 ? 10.280 14.176 -28.509 1.00 16.08 ? 166 TRP A NE1 1 ATOM 1211 C CE2 . TRP A 1 149 ? 9.002 14.667 -28.531 1.00 15.99 ? 166 TRP A CE2 1 ATOM 1212 C CE3 . TRP A 1 149 ? 7.379 15.376 -30.177 1.00 16.08 ? 166 TRP A CE3 1 ATOM 1213 C CZ2 . TRP A 1 149 ? 8.132 14.956 -27.478 1.00 15.76 ? 166 TRP A CZ2 1 ATOM 1214 C CZ3 . TRP A 1 149 ? 6.511 15.659 -29.136 1.00 16.14 ? 166 TRP A CZ3 1 ATOM 1215 C CH2 . TRP A 1 149 ? 6.893 15.444 -27.798 1.00 16.22 ? 166 TRP A CH2 1 ATOM 1216 N N . ARG A 1 150 ? 7.064 14.357 -33.318 1.00 16.98 ? 167 ARG A N 1 ATOM 1217 C CA . ARG A 1 150 ? 5.609 14.556 -33.220 1.00 18.52 ? 167 ARG A CA 1 ATOM 1218 C C . ARG A 1 150 ? 4.797 13.355 -33.707 1.00 17.92 ? 167 ARG A C 1 ATOM 1219 O O . ARG A 1 150 ? 3.857 12.939 -33.037 1.00 17.27 ? 167 ARG A O 1 ATOM 1220 C CB . ARG A 1 150 ? 5.165 15.817 -33.983 1.00 21.24 ? 167 ARG A CB 1 ATOM 1221 C CG . ARG A 1 150 ? 3.699 16.195 -33.740 1.00 24.16 ? 167 ARG A CG 1 ATOM 1222 C CD . ARG A 1 150 ? 3.128 17.068 -34.840 1.00 26.91 ? 167 ARG A CD 1 ATOM 1223 N NE . ARG A 1 150 ? 3.794 18.363 -34.893 1.00 30.44 ? 167 ARG A NE 1 ATOM 1224 C CZ . ARG A 1 150 ? 3.423 19.477 -34.250 1.00 33.85 ? 167 ARG A CZ 1 ATOM 1225 N NH1 . ARG A 1 150 ? 2.359 19.524 -33.430 1.00 34.70 ? 167 ARG A NH1 1 ATOM 1226 N NH2 . ARG A 1 150 ? 4.149 20.577 -34.428 1.00 34.47 ? 167 ARG A NH2 1 ATOM 1227 N N . GLU A 1 151 ? 5.133 12.828 -34.880 1.00 17.58 ? 168 GLU A N 1 ATOM 1228 C CA . GLU A 1 151 ? 4.391 11.702 -35.439 1.00 18.77 ? 168 GLU A CA 1 ATOM 1229 C C . GLU A 1 151 ? 4.472 10.486 -34.537 1.00 17.21 ? 168 GLU A C 1 ATOM 1230 O O . GLU A 1 151 ? 3.466 9.803 -34.302 1.00 16.86 ? 168 GLU A O 1 ATOM 1231 C CB . GLU A 1 151 ? 4.903 11.340 -36.846 1.00 20.79 ? 168 GLU A CB 1 ATOM 1232 C CG . GLU A 1 151 ? 4.592 12.388 -37.903 1.00 22.39 ? 168 GLU A CG 1 ATOM 1233 C CD . GLU A 1 151 ? 3.101 12.615 -38.115 1.00 26.19 ? 168 GLU A CD 1 ATOM 1234 O OE1 . GLU A 1 151 ? 2.342 11.634 -38.221 1.00 28.13 ? 168 GLU A OE1 1 ATOM 1235 O OE2 . GLU A 1 151 ? 2.680 13.793 -38.190 1.00 32.08 ? 168 GLU A OE2 1 ATOM 1236 N N . PHE A 1 152 ? 5.662 10.219 -34.015 1.00 16.34 ? 169 PHE A N 1 ATOM 1237 C CA . PHE A 1 152 ? 5.837 9.057 -33.160 1.00 16.67 ? 169 PHE A CA 1 ATOM 1238 C C . PHE A 1 152 ? 5.109 9.197 -31.820 1.00 15.87 ? 169 PHE A C 1 ATOM 1239 O O . PHE A 1 152 ? 4.403 8.275 -31.396 1.00 16.22 ? 169 PHE A O 1 ATOM 1240 C CB . PHE A 1 152 ? 7.308 8.728 -32.918 1.00 16.98 ? 169 PHE A CB 1 ATOM 1241 C CG . PHE A 1 152 ? 7.488 7.532 -32.036 1.00 17.75 ? 169 PHE A CG 1 ATOM 1242 C CD1 . PHE A 1 152 ? 7.249 6.263 -32.531 1.00 18.26 ? 169 PHE A CD1 1 ATOM 1243 C CD2 . PHE A 1 152 ? 7.807 7.683 -30.690 1.00 18.68 ? 169 PHE A CD2 1 ATOM 1244 C CE1 . PHE A 1 152 ? 7.376 5.150 -31.718 1.00 18.75 ? 169 PHE A CE1 1 ATOM 1245 C CE2 . PHE A 1 152 ? 7.919 6.577 -29.870 1.00 18.73 ? 169 PHE A CE2 1 ATOM 1246 C CZ . PHE A 1 152 ? 7.702 5.312 -30.382 1.00 18.57 ? 169 PHE A CZ 1 ATOM 1247 N N . TYR A 1 153 ? 5.295 10.326 -31.147 1.00 15.53 ? 170 TYR A N 1 ATOM 1248 C CA . TYR A 1 153 ? 4.659 10.529 -29.838 1.00 15.39 ? 170 TYR A CA 1 ATOM 1249 C C . TYR A 1 153 ? 3.143 10.563 -29.941 1.00 15.63 ? 170 TYR A C 1 ATOM 1250 O O . TYR A 1 153 ? 2.450 10.036 -29.077 1.00 15.61 ? 170 TYR A O 1 ATOM 1251 C CB . TYR A 1 153 ? 5.156 11.799 -29.156 1.00 15.31 ? 170 TYR A CB 1 ATOM 1252 C CG . TYR A 1 153 ? 6.431 11.616 -28.368 1.00 15.39 ? 170 TYR A CG 1 ATOM 1253 C CD1 . TYR A 1 153 ? 7.666 11.499 -29.011 1.00 15.15 ? 170 TYR A CD1 1 ATOM 1254 C CD2 . TYR A 1 153 ? 6.412 11.570 -26.979 1.00 15.19 ? 170 TYR A CD2 1 ATOM 1255 C CE1 . TYR A 1 153 ? 8.831 11.337 -28.293 1.00 15.01 ? 170 TYR A CE1 1 ATOM 1256 C CE2 . TYR A 1 153 ? 7.585 11.407 -26.249 1.00 15.27 ? 170 TYR A CE2 1 ATOM 1257 C CZ . TYR A 1 153 ? 8.789 11.289 -26.914 1.00 14.98 ? 170 TYR A CZ 1 ATOM 1258 O OH . TYR A 1 153 ? 9.964 11.147 -26.205 1.00 15.52 ? 170 TYR A OH 1 ATOM 1259 N N . ASP A 1 154 ? 2.624 11.165 -30.999 1.00 16.29 ? 171 ASP A N 1 ATOM 1260 C CA . ASP A 1 154 ? 1.169 11.177 -31.205 1.00 17.20 ? 171 ASP A CA 1 ATOM 1261 C C . ASP A 1 154 ? 0.609 9.758 -31.327 1.00 17.49 ? 171 ASP A C 1 ATOM 1262 O O . ASP A 1 154 ? -0.452 9.462 -30.784 1.00 17.03 ? 171 ASP A O 1 ATOM 1263 C CB . ASP A 1 154 ? 0.789 11.996 -32.444 1.00 17.67 ? 171 ASP A CB 1 ATOM 1264 C CG . ASP A 1 154 ? 0.982 13.491 -32.263 1.00 18.71 ? 171 ASP A CG 1 ATOM 1265 O OD1 . ASP A 1 154 ? 1.360 13.972 -31.176 1.00 19.22 ? 171 ASP A OD1 1 ATOM 1266 O OD2 . ASP A 1 154 ? 0.745 14.215 -33.248 1.00 19.45 ? 171 ASP A OD2 1 ATOM 1267 N N . LYS A 1 155 ? 1.328 8.875 -32.015 1.00 17.68 ? 172 LYS A N 1 ATOM 1268 C CA . LYS A 1 155 ? 0.843 7.514 -32.246 1.00 18.86 ? 172 LYS A CA 1 ATOM 1269 C C . LYS A 1 155 ? 1.165 6.536 -31.131 1.00 18.18 ? 172 LYS A C 1 ATOM 1270 O O . LYS A 1 155 ? 0.327 5.700 -30.797 1.00 18.45 ? 172 LYS A O 1 ATOM 1271 C CB . LYS A 1 155 ? 1.363 6.982 -33.575 1.00 20.73 ? 172 LYS A CB 1 ATOM 1272 C CG . LYS A 1 155 ? 0.744 7.702 -34.764 1.00 22.83 ? 172 LYS A CG 1 ATOM 1273 C CD . LYS A 1 155 ? 1.142 7.006 -36.043 1.00 25.15 ? 172 LYS A CD 1 ATOM 1274 C CE . LYS A 1 155 ? 0.548 7.695 -37.261 1.00 27.62 ? 172 LYS A CE 1 ATOM 1275 N NZ . LYS A 1 155 ? 0.290 6.699 -38.326 1.00 29.67 ? 172 LYS A NZ 1 ATOM 1276 N N . ALA A 1 156 ? 2.370 6.622 -30.568 1.00 17.05 ? 173 ALA A N 1 ATOM 1277 C CA . ALA A 1 156 ? 2.792 5.714 -29.494 1.00 17.37 ? 173 ALA A CA 1 ATOM 1278 C C . ALA A 1 156 ? 2.295 6.154 -28.113 1.00 17.10 ? 173 ALA A C 1 ATOM 1279 O O . ALA A 1 156 ? 2.101 5.323 -27.223 1.00 16.45 ? 173 ALA A O 1 ATOM 1280 C CB . ALA A 1 156 ? 4.308 5.579 -29.485 1.00 17.47 ? 173 ALA A CB 1 ATOM 1281 N N . GLY A 1 157 ? 2.101 7.459 -27.931 1.00 17.18 ? 174 GLY A N 1 ATOM 1282 C CA . GLY A 1 157 ? 1.649 8.005 -26.659 1.00 17.03 ? 174 GLY A CA 1 ATOM 1283 C C . GLY A 1 157 ? 0.157 8.263 -26.595 1.00 17.44 ? 174 GLY A C 1 ATOM 1284 O O . GLY A 1 157 ? -0.594 7.550 -25.927 1.00 16.94 ? 174 GLY A O 1 ATOM 1285 N N . THR A 1 158 ? -0.268 9.308 -27.292 1.00 17.92 ? 175 THR A N 1 ATOM 1286 C CA . THR A 1 158 ? -1.613 9.843 -27.133 1.00 18.17 ? 175 THR A CA 1 ATOM 1287 C C . THR A 1 158 ? -2.711 8.824 -27.416 1.00 18.82 ? 175 THR A C 1 ATOM 1288 O O . THR A 1 158 ? -3.703 8.771 -26.697 1.00 18.49 ? 175 THR A O 1 ATOM 1289 C CB . THR A 1 158 ? -1.784 11.098 -27.996 1.00 18.09 ? 175 THR A CB 1 ATOM 1290 O OG1 . THR A 1 158 ? -0.728 12.009 -27.673 1.00 17.69 ? 175 THR A OG1 1 ATOM 1291 C CG2 . THR A 1 158 ? -3.142 11.759 -27.753 1.00 18.09 ? 175 THR A CG2 1 ATOM 1292 N N . ALA A 1 159 ? -2.482 7.969 -28.411 1.00 19.81 ? 176 ALA A N 1 ATOM 1293 C CA . ALA A 1 159 ? -3.449 6.956 -28.827 1.00 19.95 ? 176 ALA A CA 1 ATOM 1294 C C . ALA A 1 159 ? -3.882 5.980 -27.730 1.00 20.45 ? 176 ALA A C 1 ATOM 1295 O O . ALA A 1 159 ? -4.962 5.408 -27.835 1.00 21.08 ? 176 ALA A O 1 ATOM 1296 C CB . ALA A 1 159 ? -2.904 6.177 -30.018 1.00 20.34 ? 176 ALA A CB 1 ATOM 1297 N N . VAL A 1 160 ? -3.059 5.779 -26.697 1.00 19.58 ? 177 VAL A N 1 ATOM 1298 C CA . VAL A 1 160 ? -3.387 4.826 -25.636 1.00 19.85 ? 177 VAL A CA 1 ATOM 1299 C C . VAL A 1 160 ? -3.716 5.454 -24.278 1.00 19.73 ? 177 VAL A C 1 ATOM 1300 O O . VAL A 1 160 ? -3.697 4.760 -23.273 1.00 19.38 ? 177 VAL A O 1 ATOM 1301 C CB . VAL A 1 160 ? -2.306 3.721 -25.492 1.00 20.15 ? 177 VAL A CB 1 ATOM 1302 C CG1 . VAL A 1 160 ? -2.245 2.898 -26.767 1.00 20.63 ? 177 VAL A CG1 1 ATOM 1303 C CG2 . VAL A 1 160 ? -0.935 4.293 -25.159 1.00 20.54 ? 177 VAL A CG2 1 ATOM 1304 N N . ARG A 1 161 ? -4.055 6.748 -24.246 1.00 20.64 ? 178 ARG A N 1 ATOM 1305 C CA . ARG A 1 161 ? -4.410 7.415 -22.980 1.00 22.28 ? 178 ARG A CA 1 ATOM 1306 C C . ARG A 1 161 ? -5.488 6.669 -22.185 1.00 21.61 ? 178 ARG A C 1 ATOM 1307 O O . ARG A 1 161 ? -5.336 6.471 -20.983 1.00 20.12 ? 178 ARG A O 1 ATOM 1308 C CB . ARG A 1 161 ? -4.867 8.869 -23.206 1.00 24.67 ? 178 ARG A CB 1 ATOM 1309 C CG . ARG A 1 161 ? -5.369 9.577 -21.946 1.00 28.48 ? 178 ARG A CG 1 ATOM 1310 C CD . ARG A 1 161 ? -6.018 10.926 -22.239 1.00 32.44 ? 178 ARG A CD 1 ATOM 1311 N NE . ARG A 1 161 ? -5.104 12.054 -22.037 1.00 36.61 ? 178 ARG A NE 1 ATOM 1312 C CZ . ARG A 1 161 ? -4.682 12.503 -20.848 1.00 38.85 ? 178 ARG A CZ 1 ATOM 1313 N NH1 . ARG A 1 161 ? -5.067 11.927 -19.693 1.00 39.19 ? 178 ARG A NH1 1 ATOM 1314 N NH2 . ARG A 1 161 ? -3.846 13.536 -20.818 1.00 40.90 ? 178 ARG A NH2 1 ATOM 1315 N N . SER A 1 162 ? -6.579 6.273 -22.838 1.00 21.72 ? 179 SER A N 1 ATOM 1316 C CA . SER A 1 162 ? -7.689 5.653 -22.098 1.00 22.17 ? 179 SER A CA 1 ATOM 1317 C C . SER A 1 162 ? -7.308 4.266 -21.551 1.00 21.30 ? 179 SER A C 1 ATOM 1318 O O . SER A 1 162 ? -7.648 3.941 -20.416 1.00 19.81 ? 179 SER A O 1 ATOM 1319 C CB . SER A 1 162 ? -8.974 5.606 -22.932 1.00 22.94 ? 179 SER A CB 1 ATOM 1320 O OG . SER A 1 162 ? -8.805 4.791 -24.068 1.00 26.86 ? 179 SER A OG 1 ATOM 1321 N N . GLN A 1 163 ? -6.569 3.478 -22.331 1.00 20.59 ? 180 GLN A N 1 ATOM 1322 C CA . GLN A 1 163 ? -6.062 2.182 -21.854 1.00 21.21 ? 180 GLN A CA 1 ATOM 1323 C C . GLN A 1 163 ? -5.110 2.394 -20.679 1.00 20.21 ? 180 GLN A C 1 ATOM 1324 O O . GLN A 1 163 ? -5.186 1.693 -19.661 1.00 20.18 ? 180 GLN A O 1 ATOM 1325 C CB . GLN A 1 163 ? -5.337 1.412 -22.959 1.00 22.47 ? 180 GLN A CB 1 ATOM 1326 C CG . GLN A 1 163 ? -6.235 0.933 -24.092 1.00 24.47 ? 180 GLN A CG 1 ATOM 1327 C CD . GLN A 1 163 ? -6.354 1.929 -25.226 1.00 26.01 ? 180 GLN A CD 1 ATOM 1328 O OE1 . GLN A 1 163 ? -6.100 3.126 -25.056 1.00 27.41 ? 180 GLN A OE1 1 ATOM 1329 N NE2 . GLN A 1 163 ? -6.763 1.447 -26.387 1.00 28.43 ? 180 GLN A NE2 1 ATOM 1330 N N . PHE A 1 164 ? -4.228 3.379 -20.810 1.00 18.89 ? 181 PHE A N 1 ATOM 1331 C CA . PHE A 1 164 ? -3.298 3.690 -19.729 1.00 18.33 ? 181 PHE A CA 1 ATOM 1332 C C . PHE A 1 164 ? -4.010 4.106 -18.442 1.00 18.47 ? 181 PHE A C 1 ATOM 1333 O O . PHE A 1 164 ? -3.601 3.707 -17.357 1.00 18.13 ? 181 PHE A O 1 ATOM 1334 C CB . PHE A 1 164 ? -2.294 4.758 -20.146 1.00 17.56 ? 181 PHE A CB 1 ATOM 1335 C CG . PHE A 1 164 ? -1.142 4.863 -19.215 1.00 17.49 ? 181 PHE A CG 1 ATOM 1336 C CD1 . PHE A 1 164 ? -0.049 4.013 -19.352 1.00 17.45 ? 181 PHE A CD1 1 ATOM 1337 C CD2 . PHE A 1 164 ? -1.172 5.753 -18.155 1.00 17.31 ? 181 PHE A CD2 1 ATOM 1338 C CE1 . PHE A 1 164 ? 1.018 4.085 -18.471 1.00 17.25 ? 181 PHE A CE1 1 ATOM 1339 C CE2 . PHE A 1 164 ? -0.106 5.831 -17.273 1.00 17.58 ? 181 PHE A CE2 1 ATOM 1340 C CZ . PHE A 1 164 ? 0.992 4.993 -17.434 1.00 17.42 ? 181 PHE A CZ 1 ATOM 1341 N N . GLU A 1 165 ? -5.063 4.910 -18.560 1.00 20.29 ? 182 GLU A N 1 ATOM 1342 C CA . GLU A 1 165 ? -5.855 5.303 -17.390 1.00 21.47 ? 182 GLU A CA 1 ATOM 1343 C C . GLU A 1 165 ? -6.444 4.098 -16.688 1.00 20.06 ? 182 GLU A C 1 ATOM 1344 O O . GLU A 1 165 ? -6.358 3.989 -15.475 1.00 18.66 ? 182 GLU A O 1 ATOM 1345 C CB . GLU A 1 165 ? -6.984 6.271 -17.758 1.00 24.25 ? 182 GLU A CB 1 ATOM 1346 C CG . GLU A 1 165 ? -6.505 7.677 -18.081 1.00 28.41 ? 182 GLU A CG 1 ATOM 1347 C CD . GLU A 1 165 ? -7.632 8.622 -18.480 1.00 32.56 ? 182 GLU A CD 1 ATOM 1348 O OE1 . GLU A 1 165 ? -8.792 8.171 -18.610 1.00 36.92 ? 182 GLU A OE1 1 ATOM 1349 O OE2 . GLU A 1 165 ? -7.357 9.820 -18.664 1.00 35.44 ? 182 GLU A OE2 1 ATOM 1350 N N . ARG A 1 166 ? -7.036 3.191 -17.459 1.00 20.36 ? 183 ARG A N 1 ATOM 1351 C CA . ARG A 1 166 ? -7.629 1.987 -16.889 1.00 21.04 ? 183 ARG A CA 1 ATOM 1352 C C . ARG A 1 166 ? -6.566 1.075 -16.249 1.00 19.50 ? 183 ARG A C 1 ATOM 1353 O O . ARG A 1 166 ? -6.798 0.485 -15.196 1.00 19.24 ? 183 ARG A O 1 ATOM 1354 C CB . ARG A 1 166 ? -8.442 1.237 -17.955 1.00 22.30 ? 183 ARG A CB 1 ATOM 1355 C CG . ARG A 1 166 ? -9.296 0.096 -17.442 1.00 24.22 ? 183 ARG A CG 1 ATOM 1356 C CD . ARG A 1 166 ? -10.219 0.526 -16.311 1.00 25.27 ? 183 ARG A CD 1 ATOM 1357 N NE . ARG A 1 166 ? -10.988 -0.607 -15.813 1.00 26.28 ? 183 ARG A NE 1 ATOM 1358 C CZ . ARG A 1 166 ? -11.325 -0.814 -14.539 1.00 27.49 ? 183 ARG A CZ 1 ATOM 1359 N NH1 . ARG A 1 166 ? -10.991 0.042 -13.573 1.00 28.80 ? 183 ARG A NH1 1 ATOM 1360 N NH2 . ARG A 1 166 ? -12.017 -1.906 -14.225 1.00 28.35 ? 183 ARG A NH2 1 ATOM 1361 N N . TYR A 1 167 ? -5.405 0.970 -16.894 1.00 18.83 ? 184 TYR A N 1 ATOM 1362 C CA . TYR A 1 167 ? -4.254 0.240 -16.317 1.00 18.35 ? 184 TYR A CA 1 ATOM 1363 C C . TYR A 1 167 ? -3.863 0.810 -14.956 1.00 17.93 ? 184 TYR A C 1 ATOM 1364 O O . TYR A 1 167 ? -3.665 0.058 -14.001 1.00 18.18 ? 184 TYR A O 1 ATOM 1365 C CB . TYR A 1 167 ? -3.060 0.239 -17.296 1.00 17.82 ? 184 TYR A CB 1 ATOM 1366 C CG . TYR A 1 167 ? -1.667 0.231 -16.694 1.00 17.38 ? 184 TYR A CG 1 ATOM 1367 C CD1 . TYR A 1 167 ? -1.120 -0.928 -16.140 1.00 17.63 ? 184 TYR A CD1 1 ATOM 1368 C CD2 . TYR A 1 167 ? -0.890 1.384 -16.689 1.00 17.28 ? 184 TYR A CD2 1 ATOM 1369 C CE1 . TYR A 1 167 ? 0.162 -0.925 -15.601 1.00 17.51 ? 184 TYR A CE1 1 ATOM 1370 C CE2 . TYR A 1 167 ? 0.378 1.395 -16.149 1.00 17.45 ? 184 TYR A CE2 1 ATOM 1371 C CZ . TYR A 1 167 ? 0.908 0.237 -15.623 1.00 17.63 ? 184 TYR A CZ 1 ATOM 1372 O OH . TYR A 1 167 ? 2.186 0.256 -15.121 1.00 18.64 ? 184 TYR A OH 1 ATOM 1373 N N . VAL A 1 168 ? -3.778 2.134 -14.856 1.00 18.02 ? 185 VAL A N 1 ATOM 1374 C CA . VAL A 1 168 ? -3.427 2.763 -13.570 1.00 18.43 ? 185 VAL A CA 1 ATOM 1375 C C . VAL A 1 168 ? -4.441 2.390 -12.489 1.00 18.41 ? 185 VAL A C 1 ATOM 1376 O O . VAL A 1 168 ? -4.059 2.029 -11.376 1.00 17.99 ? 185 VAL A O 1 ATOM 1377 C CB . VAL A 1 168 ? -3.265 4.294 -13.712 1.00 18.46 ? 185 VAL A CB 1 ATOM 1378 C CG1 . VAL A 1 168 ? -3.206 4.989 -12.355 1.00 19.47 ? 185 VAL A CG1 1 ATOM 1379 C CG2 . VAL A 1 168 ? -1.998 4.599 -14.504 1.00 18.34 ? 185 VAL A CG2 1 ATOM 1380 N N . GLU A 1 169 ? -5.723 2.436 -12.836 1.00 19.41 ? 186 GLU A N 1 ATOM 1381 C CA . GLU A 1 169 ? -6.795 2.044 -11.903 1.00 20.78 ? 186 GLU A CA 1 ATOM 1382 C C . GLU A 1 169 ? -6.664 0.597 -11.426 1.00 19.74 ? 186 GLU A C 1 ATOM 1383 O O . GLU A 1 169 ? -6.740 0.333 -10.220 1.00 19.37 ? 186 GLU A O 1 ATOM 1384 C CB . GLU A 1 169 ? -8.178 2.270 -12.535 1.00 22.69 ? 186 GLU A CB 1 ATOM 1385 C CG . GLU A 1 169 ? -8.530 3.740 -12.736 1.00 25.33 ? 186 GLU A CG 1 ATOM 1386 C CD . GLU A 1 169 ? -9.891 3.968 -13.406 1.00 29.27 ? 186 GLU A CD 1 ATOM 1387 O OE1 . GLU A 1 169 ? -10.516 2.991 -13.881 1.00 30.74 ? 186 GLU A OE1 1 ATOM 1388 O OE2 . GLU A 1 169 ? -10.332 5.146 -13.472 1.00 31.33 ? 186 GLU A OE2 1 ATOM 1389 N N . LEU A 1 170 ? -6.455 -0.332 -12.362 1.00 19.19 ? 187 LEU A N 1 ATOM 1390 C CA . LEU A 1 170 ? -6.366 -1.761 -12.015 1.00 19.03 ? 187 LEU A CA 1 ATOM 1391 C C . LEU A 1 170 ? -5.077 -2.099 -11.268 1.00 18.73 ? 187 LEU A C 1 ATOM 1392 O O . LEU A 1 170 ? -5.092 -2.904 -10.337 1.00 18.17 ? 187 LEU A O 1 ATOM 1393 C CB . LEU A 1 170 ? -6.535 -2.647 -13.248 1.00 19.98 ? 187 LEU A CB 1 ATOM 1394 C CG . LEU A 1 170 ? -7.949 -2.618 -13.844 1.00 20.65 ? 187 LEU A CG 1 ATOM 1395 C CD1 . LEU A 1 170 ? -7.984 -3.262 -15.227 1.00 21.49 ? 187 LEU A CD1 1 ATOM 1396 C CD2 . LEU A 1 170 ? -8.946 -3.272 -12.902 1.00 21.20 ? 187 LEU A CD2 1 ATOM 1397 N N . ASN A 1 171 ? -3.971 -1.480 -11.682 1.00 18.51 ? 188 ASN A N 1 ATOM 1398 C CA . ASN A 1 171 ? -2.706 -1.579 -10.953 1.00 18.27 ? 188 ASN A CA 1 ATOM 1399 C C . ASN A 1 171 ? -2.868 -1.128 -9.501 1.00 17.74 ? 188 ASN A C 1 ATOM 1400 O O . ASN A 1 171 ? -2.368 -1.788 -8.586 1.00 17.31 ? 188 ASN A O 1 ATOM 1401 C CB . ASN A 1 171 ? -1.603 -0.764 -11.665 1.00 17.97 ? 188 ASN A CB 1 ATOM 1402 C CG . ASN A 1 171 ? -0.293 -0.749 -10.894 1.00 17.60 ? 188 ASN A CG 1 ATOM 1403 O OD1 . ASN A 1 171 ? -0.196 -0.130 -9.849 1.00 17.90 ? 188 ASN A OD1 1 ATOM 1404 N ND2 . ASN A 1 171 ? 0.716 -1.431 -11.412 1.00 17.35 ? 188 ASN A ND2 1 ATOM 1405 N N . THR A 1 172 ? -3.560 -0.008 -9.298 1.00 17.71 ? 189 THR A N 1 ATOM 1406 C CA . THR A 1 172 ? -3.839 0.495 -7.957 1.00 18.43 ? 189 THR A CA 1 ATOM 1407 C C . THR A 1 172 ? -4.727 -0.469 -7.158 1.00 18.75 ? 189 THR A C 1 ATOM 1408 O O . THR A 1 172 ? -4.456 -0.746 -5.990 1.00 19.26 ? 189 THR A O 1 ATOM 1409 C CB . THR A 1 172 ? -4.492 1.899 -8.010 1.00 19.16 ? 189 THR A CB 1 ATOM 1410 O OG1 . THR A 1 172 ? -3.654 2.802 -8.755 1.00 18.75 ? 189 THR A OG1 1 ATOM 1411 C CG2 . THR A 1 172 ? -4.688 2.451 -6.610 1.00 19.53 ? 189 THR A CG2 1 ATOM 1412 N N . LYS A 1 173 ? -5.773 -0.989 -7.791 1.00 19.81 ? 190 LYS A N 1 ATOM 1413 C CA . LYS A 1 173 ? -6.668 -1.956 -7.140 1.00 20.09 ? 190 LYS A CA 1 ATOM 1414 C C . LYS A 1 173 ? -5.901 -3.211 -6.690 1.00 19.72 ? 190 LYS A C 1 ATOM 1415 O O . LYS A 1 173 ? -6.051 -3.682 -5.554 1.00 19.25 ? 190 LYS A O 1 ATOM 1416 C CB . LYS A 1 173 ? -7.822 -2.321 -8.080 1.00 21.48 ? 190 LYS A CB 1 ATOM 1417 C CG . LYS A 1 173 ? -8.896 -3.200 -7.436 1.00 23.34 ? 190 LYS A CG 1 ATOM 1418 C CD . LYS A 1 173 ? -10.095 -3.397 -8.349 1.00 24.93 ? 190 LYS A CD 1 ATOM 1419 C CE . LYS A 1 173 ? -11.199 -4.142 -7.606 1.00 26.31 ? 190 LYS A CE 1 ATOM 1420 N NZ . LYS A 1 173 ? -12.444 -4.294 -8.401 1.00 27.70 ? 190 LYS A NZ 1 ATOM 1421 N N . ALA A 1 174 ? -5.049 -3.720 -7.575 1.00 19.08 ? 191 ALA A N 1 ATOM 1422 C CA . ALA A 1 174 ? -4.224 -4.887 -7.277 1.00 19.02 ? 191 ALA A CA 1 ATOM 1423 C C . ALA A 1 174 ? -3.299 -4.660 -6.096 1.00 19.32 ? 191 ALA A C 1 ATOM 1424 O O . ALA A 1 174 ? -3.171 -5.543 -5.228 1.00 18.71 ? 191 ALA A O 1 ATOM 1425 C CB . ALA A 1 174 ? -3.411 -5.290 -8.492 1.00 18.95 ? 191 ALA A CB 1 ATOM 1426 N N . ALA A 1 175 ? -2.647 -3.493 -6.078 1.00 19.28 ? 192 ALA A N 1 ATOM 1427 C CA . ALA A 1 175 ? -1.719 -3.131 -5.009 1.00 19.63 ? 192 ALA A CA 1 ATOM 1428 C C . ALA A 1 175 ? -2.395 -3.136 -3.643 1.00 20.28 ? 192 ALA A C 1 ATOM 1429 O O . ALA A 1 175 ? -1.867 -3.714 -2.688 1.00 20.13 ? 192 ALA A O 1 ATOM 1430 C CB . ALA A 1 175 ? -1.111 -1.762 -5.267 1.00 19.78 ? 192 ALA A CB 1 ATOM 1431 N N . LYS A 1 176 ? -3.553 -2.488 -3.568 1.00 20.83 ? 193 LYS A N 1 ATOM 1432 C CA . LYS A 1 176 ? -4.327 -2.413 -2.323 1.00 22.56 ? 193 LYS A CA 1 ATOM 1433 C C . LYS A 1 176 ? -4.831 -3.784 -1.871 1.00 22.70 ? 193 LYS A C 1 ATOM 1434 O O . LYS A 1 176 ? -4.874 -4.047 -0.672 1.00 22.60 ? 193 LYS A O 1 ATOM 1435 C CB . LYS A 1 176 ? -5.471 -1.400 -2.445 1.00 23.63 ? 193 LYS A CB 1 ATOM 1436 C CG . LYS A 1 176 ? -4.987 0.042 -2.608 1.00 25.04 ? 193 LYS A CG 1 ATOM 1437 C CD . LYS A 1 176 ? -6.134 1.044 -2.608 1.00 25.97 ? 193 LYS A CD 1 ATOM 1438 C CE . LYS A 1 176 ? -5.662 2.473 -2.856 1.00 26.65 ? 193 LYS A CE 1 ATOM 1439 N NZ . LYS A 1 176 ? -4.749 2.985 -1.787 1.00 27.36 ? 193 LYS A NZ 1 ATOM 1440 N N . LEU A 1 177 ? -5.149 -4.678 -2.812 1.00 22.79 ? 194 LEU A N 1 ATOM 1441 C CA . LEU A 1 177 ? -5.498 -6.068 -2.461 1.00 23.16 ? 194 LEU A CA 1 ATOM 1442 C C . LEU A 1 177 ? -4.325 -6.841 -1.867 1.00 23.48 ? 194 LEU A C 1 ATOM 1443 O O . LEU A 1 177 ? -4.536 -7.797 -1.130 1.00 24.21 ? 194 LEU A O 1 ATOM 1444 C CB . LEU A 1 177 ? -6.073 -6.828 -3.663 1.00 22.97 ? 194 LEU A CB 1 ATOM 1445 C CG . LEU A 1 177 ? -7.477 -6.396 -4.091 1.00 23.68 ? 194 LEU A CG 1 ATOM 1446 C CD1 . LEU A 1 177 ? -7.801 -6.920 -5.486 1.00 23.79 ? 194 LEU A CD1 1 ATOM 1447 C CD2 . LEU A 1 177 ? -8.526 -6.847 -3.077 1.00 24.08 ? 194 LEU A CD2 1 ATOM 1448 N N . ASN A 1 178 ? -3.098 -6.424 -2.181 1.00 22.80 ? 195 ASN A N 1 ATOM 1449 C CA . ASN A 1 178 ? -1.887 -7.000 -1.593 1.00 22.47 ? 195 ASN A CA 1 ATOM 1450 C C . ASN A 1 178 ? -1.344 -6.206 -0.394 1.00 23.16 ? 195 ASN A C 1 ATOM 1451 O O . ASN A 1 178 ? -0.214 -6.435 0.020 1.00 23.21 ? 195 ASN A O 1 ATOM 1452 C CB . ASN A 1 178 ? -0.818 -7.129 -2.671 1.00 23.04 ? 195 ASN A CB 1 ATOM 1453 C CG . ASN A 1 178 ? -1.197 -8.131 -3.746 1.00 23.34 ? 195 ASN A CG 1 ATOM 1454 O OD1 . ASN A 1 178 ? -1.257 -9.326 -3.479 1.00 26.34 ? 195 ASN A OD1 1 ATOM 1455 N ND2 . ASN A 1 178 ? -1.451 -7.658 -4.954 1.00 22.46 ? 195 ASN A ND2 1 ATOM 1456 N N . ASN A 1 179 ? -2.153 -5.294 0.149 1.00 23.82 ? 196 ASN A N 1 ATOM 1457 C CA . ASN A 1 179 ? -1.793 -4.440 1.292 1.00 25.92 ? 196 ASN A CA 1 ATOM 1458 C C . ASN A 1 179 ? -0.638 -3.468 1.064 1.00 24.08 ? 196 ASN A C 1 ATOM 1459 O O . ASN A 1 179 ? 0.056 -3.091 2.009 1.00 23.35 ? 196 ASN A O 1 ATOM 1460 C CB . ASN A 1 179 ? -1.563 -5.281 2.557 1.00 29.53 ? 196 ASN A CB 1 ATOM 1461 C CG . ASN A 1 179 ? -2.791 -6.054 2.963 1.00 33.97 ? 196 ASN A CG 1 ATOM 1462 O OD1 . ASN A 1 179 ? -3.914 -5.541 2.910 1.00 37.56 ? 196 ASN A OD1 1 ATOM 1463 N ND2 . ASN A 1 179 ? -2.590 -7.296 3.380 1.00 38.36 ? 196 ASN A ND2 1 ATOM 1464 N N . PHE A 1 180 ? -0.461 -3.045 -0.189 1.00 21.66 ? 197 PHE A N 1 ATOM 1465 C CA . PHE A 1 180 ? 0.422 -1.941 -0.526 1.00 20.68 ? 197 PHE A CA 1 ATOM 1466 C C . PHE A 1 180 ? -0.429 -0.703 -0.726 1.00 20.62 ? 197 PHE A C 1 ATOM 1467 O O . PHE A 1 180 ? -1.561 -0.802 -1.191 1.00 20.42 ? 197 PHE A O 1 ATOM 1468 C CB . PHE A 1 180 ? 1.198 -2.243 -1.812 1.00 20.51 ? 197 PHE A CB 1 ATOM 1469 C CG . PHE A 1 180 ? 2.184 -3.361 -1.673 1.00 19.97 ? 197 PHE A CG 1 ATOM 1470 C CD1 . PHE A 1 180 ? 3.266 -3.243 -0.800 1.00 20.20 ? 197 PHE A CD1 1 ATOM 1471 C CD2 . PHE A 1 180 ? 2.053 -4.526 -2.420 1.00 20.02 ? 197 PHE A CD2 1 ATOM 1472 C CE1 . PHE A 1 180 ? 4.190 -4.270 -0.666 1.00 19.68 ? 197 PHE A CE1 1 ATOM 1473 C CE2 . PHE A 1 180 ? 2.982 -5.557 -2.296 1.00 19.42 ? 197 PHE A CE2 1 ATOM 1474 C CZ . PHE A 1 180 ? 4.049 -5.427 -1.413 1.00 19.62 ? 197 PHE A CZ 1 ATOM 1475 N N . THR A 1 181 ? 0.105 0.465 -0.382 1.00 20.48 ? 198 THR A N 1 ATOM 1476 C CA . THR A 1 181 ? -0.611 1.720 -0.609 1.00 21.52 ? 198 THR A CA 1 ATOM 1477 C C . THR A 1 181 ? -0.934 1.924 -2.095 1.00 20.38 ? 198 THR A C 1 ATOM 1478 O O . THR A 1 181 ? -2.006 2.401 -2.436 1.00 20.60 ? 198 THR A O 1 ATOM 1479 C CB . THR A 1 181 ? 0.192 2.922 -0.086 1.00 22.70 ? 198 THR A CB 1 ATOM 1480 O OG1 . THR A 1 181 ? 0.447 2.739 1.309 1.00 24.51 ? 198 THR A OG1 1 ATOM 1481 C CG2 . THR A 1 181 ? -0.567 4.217 -0.277 1.00 25.03 ? 198 THR A CG2 1 ATOM 1482 N N . SER A 1 182 ? 0.015 1.578 -2.960 1.00 19.20 ? 199 SER A N 1 ATOM 1483 C CA . SER A 1 182 ? -0.133 1.749 -4.400 1.00 18.53 ? 199 SER A CA 1 ATOM 1484 C C . SER A 1 182 ? 0.854 0.862 -5.129 1.00 17.74 ? 199 SER A C 1 ATOM 1485 O O . SER A 1 182 ? 1.680 0.192 -4.502 1.00 16.33 ? 199 SER A O 1 ATOM 1486 C CB . SER A 1 182 ? 0.129 3.201 -4.802 1.00 18.92 ? 199 SER A CB 1 ATOM 1487 O OG . SER A 1 182 ? 1.519 3.496 -4.832 1.00 19.86 ? 199 SER A OG 1 ATOM 1488 N N . GLY A 1 183 ? 0.787 0.891 -6.458 1.00 17.24 ? 200 GLY A N 1 ATOM 1489 C CA . GLY A 1 183 ? 1.727 0.152 -7.284 1.00 17.88 ? 200 GLY A CA 1 ATOM 1490 C C . GLY A 1 183 ? 3.169 0.579 -7.111 1.00 17.51 ? 200 GLY A C 1 ATOM 1491 O O . GLY A 1 183 ? 4.067 -0.174 -7.458 1.00 18.01 ? 200 GLY A O 1 ATOM 1492 N N . ALA A 1 184 ? 3.386 1.807 -6.629 1.00 18.01 ? 201 ALA A N 1 ATOM 1493 C CA . ALA A 1 184 ? 4.731 2.306 -6.342 1.00 17.91 ? 201 ALA A CA 1 ATOM 1494 C C . ALA A 1 184 ? 5.362 1.477 -5.240 1.00 18.24 ? 201 ALA A C 1 ATOM 1495 O O . ALA A 1 184 ? 6.498 1.028 -5.351 1.00 17.39 ? 201 ALA A O 1 ATOM 1496 C CB . ALA A 1 184 ? 4.678 3.771 -5.932 1.00 18.04 ? 201 ALA A CB 1 ATOM 1497 N N . GLU A 1 185 ? 4.598 1.261 -4.178 1.00 18.25 ? 202 GLU A N 1 ATOM 1498 C CA . GLU A 1 185 ? 5.065 0.453 -3.047 1.00 18.74 ? 202 GLU A CA 1 ATOM 1499 C C . GLU A 1 185 ? 5.197 -1.012 -3.437 1.00 18.09 ? 202 GLU A C 1 ATOM 1500 O O . GLU A 1 185 ? 6.109 -1.683 -2.974 1.00 17.59 ? 202 GLU A O 1 ATOM 1501 C CB . GLU A 1 185 ? 4.139 0.614 -1.838 1.00 19.70 ? 202 GLU A CB 1 ATOM 1502 C CG . GLU A 1 185 ? 4.235 1.989 -1.178 1.00 20.58 ? 202 GLU A CG 1 ATOM 1503 C CD . GLU A 1 185 ? 3.581 3.105 -1.972 1.00 21.55 ? 202 GLU A CD 1 ATOM 1504 O OE1 . GLU A 1 185 ? 2.593 2.858 -2.697 1.00 22.29 ? 202 GLU A OE1 1 ATOM 1505 O OE2 . GLU A 1 185 ? 4.059 4.249 -1.877 1.00 22.40 ? 202 GLU A OE2 1 ATOM 1506 N N . ALA A 1 186 ? 4.311 -1.490 -4.312 1.00 17.73 ? 203 ALA A N 1 ATOM 1507 C CA . ALA A 1 186 ? 4.432 -2.837 -4.871 1.00 17.77 ? 203 ALA A CA 1 ATOM 1508 C C . ALA A 1 186 ? 5.760 -3.010 -5.614 1.00 17.89 ? 203 ALA A C 1 ATOM 1509 O O . ALA A 1 186 ? 6.486 -3.981 -5.399 1.00 18.32 ? 203 ALA A O 1 ATOM 1510 C CB . ALA A 1 186 ? 3.256 -3.143 -5.790 1.00 17.79 ? 203 ALA A CB 1 ATOM 1511 N N . TRP A 1 187 ? 6.094 -2.053 -6.470 1.00 17.07 ? 204 TRP A N 1 ATOM 1512 C CA . TRP A 1 187 ? 7.362 -2.122 -7.190 1.00 16.69 ? 204 TRP A CA 1 ATOM 1513 C C . TRP A 1 187 ? 8.547 -2.034 -6.238 1.00 17.23 ? 204 TRP A C 1 ATOM 1514 O O . TRP A 1 187 ? 9.491 -2.817 -6.347 1.00 17.59 ? 204 TRP A O 1 ATOM 1515 C CB . TRP A 1 187 ? 7.467 -1.023 -8.257 1.00 16.53 ? 204 TRP A CB 1 ATOM 1516 C CG . TRP A 1 187 ? 6.746 -1.315 -9.533 1.00 16.32 ? 204 TRP A CG 1 ATOM 1517 C CD1 . TRP A 1 187 ? 6.181 -2.511 -9.933 1.00 16.46 ? 204 TRP A CD1 1 ATOM 1518 C CD2 . TRP A 1 187 ? 6.552 -0.406 -10.616 1.00 16.16 ? 204 TRP A CD2 1 ATOM 1519 N NE1 . TRP A 1 187 ? 5.626 -2.373 -11.178 1.00 16.69 ? 204 TRP A NE1 1 ATOM 1520 C CE2 . TRP A 1 187 ? 5.846 -1.101 -11.627 1.00 16.27 ? 204 TRP A CE2 1 ATOM 1521 C CE3 . TRP A 1 187 ? 6.898 0.934 -10.832 1.00 15.93 ? 204 TRP A CE3 1 ATOM 1522 C CZ2 . TRP A 1 187 ? 5.485 -0.502 -12.830 1.00 16.19 ? 204 TRP A CZ2 1 ATOM 1523 C CZ3 . TRP A 1 187 ? 6.535 1.527 -12.034 1.00 15.95 ? 204 TRP A CZ3 1 ATOM 1524 C CH2 . TRP A 1 187 ? 5.831 0.807 -13.012 1.00 15.92 ? 204 TRP A CH2 1 ATOM 1525 N N . LEU A 1 188 ? 8.492 -1.088 -5.300 1.00 17.75 ? 205 LEU A N 1 ATOM 1526 C CA . LEU A 1 188 ? 9.598 -0.885 -4.370 1.00 18.10 ? 205 LEU A CA 1 ATOM 1527 C C . LEU A 1 188 ? 9.864 -2.089 -3.470 1.00 18.47 ? 205 LEU A C 1 ATOM 1528 O O . LEU A 1 188 ? 11.004 -2.284 -3.039 1.00 18.52 ? 205 LEU A O 1 ATOM 1529 C CB . LEU A 1 188 ? 9.410 0.401 -3.565 1.00 18.66 ? 205 LEU A CB 1 ATOM 1530 C CG . LEU A 1 188 ? 9.783 1.644 -4.392 1.00 19.96 ? 205 LEU A CG 1 ATOM 1531 C CD1 . LEU A 1 188 ? 9.192 2.920 -3.809 1.00 20.98 ? 205 LEU A CD1 1 ATOM 1532 C CD2 . LEU A 1 188 ? 11.295 1.780 -4.519 1.00 20.37 ? 205 LEU A CD2 1 ATOM 1533 N N . ASP A 1 189 ? 8.829 -2.906 -3.236 1.00 17.76 ? 206 ASP A N 1 ATOM 1534 C CA . ASP A 1 189 ? 8.948 -4.167 -2.488 1.00 18.63 ? 206 ASP A CA 1 ATOM 1535 C C . ASP A 1 189 ? 10.028 -5.098 -3.027 1.00 18.30 ? 206 ASP A C 1 ATOM 1536 O O . ASP A 1 189 ? 10.631 -5.839 -2.263 1.00 18.25 ? 206 ASP A O 1 ATOM 1537 C CB . ASP A 1 189 ? 7.602 -4.917 -2.471 1.00 18.86 ? 206 ASP A CB 1 ATOM 1538 C CG . ASP A 1 189 ? 7.610 -6.113 -1.533 1.00 19.86 ? 206 ASP A CG 1 ATOM 1539 O OD1 . ASP A 1 189 ? 7.862 -5.924 -0.336 1.00 18.85 ? 206 ASP A OD1 1 ATOM 1540 O OD2 . ASP A 1 189 ? 7.376 -7.247 -1.994 1.00 21.71 ? 206 ASP A OD2 1 ATOM 1541 N N . GLU A 1 190 ? 10.291 -5.035 -4.331 1.00 18.32 ? 207 GLU A N 1 ATOM 1542 C CA . GLU A 1 190 ? 11.303 -5.895 -4.955 1.00 19.04 ? 207 GLU A CA 1 ATOM 1543 C C . GLU A 1 190 ? 12.740 -5.634 -4.491 1.00 18.33 ? 207 GLU A C 1 ATOM 1544 O O . GLU A 1 190 ? 13.614 -6.464 -4.726 1.00 18.53 ? 207 GLU A O 1 ATOM 1545 C CB . GLU A 1 190 ? 11.266 -5.777 -6.482 1.00 19.89 ? 207 GLU A CB 1 ATOM 1546 C CG . GLU A 1 190 ? 9.941 -6.132 -7.125 1.00 21.36 ? 207 GLU A CG 1 ATOM 1547 C CD . GLU A 1 190 ? 9.494 -7.541 -6.822 1.00 22.89 ? 207 GLU A CD 1 ATOM 1548 O OE1 . GLU A 1 190 ? 10.341 -8.451 -6.713 1.00 23.65 ? 207 GLU A OE1 1 ATOM 1549 O OE2 . GLU A 1 190 ? 8.279 -7.732 -6.685 1.00 26.77 ? 207 GLU A OE2 1 ATOM 1550 N N . TYR A 1 191 ? 12.983 -4.494 -3.852 1.00 18.31 ? 208 TYR A N 1 ATOM 1551 C CA . TYR A 1 191 ? 14.316 -4.152 -3.350 1.00 17.89 ? 208 TYR A CA 1 ATOM 1552 C C . TYR A 1 191 ? 14.542 -4.471 -1.876 1.00 17.88 ? 208 TYR A C 1 ATOM 1553 O O . TYR A 1 191 ? 15.659 -4.276 -1.386 1.00 17.34 ? 208 TYR A O 1 ATOM 1554 C CB . TYR A 1 191 ? 14.595 -2.675 -3.647 1.00 17.93 ? 208 TYR A CB 1 ATOM 1555 C CG . TYR A 1 191 ? 14.510 -2.414 -5.124 1.00 17.99 ? 208 TYR A CG 1 ATOM 1556 C CD1 . TYR A 1 191 ? 15.554 -2.769 -5.969 1.00 18.02 ? 208 TYR A CD1 1 ATOM 1557 C CD2 . TYR A 1 191 ? 13.354 -1.885 -5.693 1.00 18.41 ? 208 TYR A CD2 1 ATOM 1558 C CE1 . TYR A 1 191 ? 15.470 -2.558 -7.333 1.00 17.95 ? 208 TYR A CE1 1 ATOM 1559 C CE2 . TYR A 1 191 ? 13.257 -1.679 -7.054 1.00 18.36 ? 208 TYR A CE2 1 ATOM 1560 C CZ . TYR A 1 191 ? 14.320 -2.022 -7.869 1.00 17.83 ? 208 TYR A CZ 1 ATOM 1561 O OH . TYR A 1 191 ? 14.234 -1.823 -9.216 1.00 17.65 ? 208 TYR A OH 1 ATOM 1562 N N . GLU A 1 192 ? 13.509 -4.966 -1.182 1.00 18.13 ? 209 GLU A N 1 ATOM 1563 C CA . GLU A 1 192 ? 13.635 -5.479 0.202 1.00 18.94 ? 209 GLU A CA 1 ATOM 1564 C C . GLU A 1 192 ? 14.425 -4.537 1.115 1.00 18.87 ? 209 GLU A C 1 ATOM 1565 O O . GLU A 1 192 ? 15.342 -4.966 1.834 1.00 19.01 ? 209 GLU A O 1 ATOM 1566 C CB . GLU A 1 192 ? 14.312 -6.854 0.218 1.00 19.95 ? 209 GLU A CB 1 ATOM 1567 C CG . GLU A 1 192 ? 13.583 -7.963 -0.500 1.00 21.37 ? 209 GLU A CG 1 ATOM 1568 C CD . GLU A 1 192 ? 14.258 -9.309 -0.259 1.00 22.48 ? 209 GLU A CD 1 ATOM 1569 O OE1 . GLU A 1 192 ? 14.194 -9.837 0.865 1.00 23.17 ? 209 GLU A OE1 1 ATOM 1570 O OE2 . GLU A 1 192 ? 14.859 -9.846 -1.196 1.00 22.94 ? 209 GLU A OE2 1 ATOM 1571 N N . ASP A 1 193 ? 14.084 -3.256 1.058 1.00 18.99 ? 210 ASP A N 1 ATOM 1572 C CA . ASP A 1 193 ? 14.842 -2.219 1.762 1.00 19.69 ? 210 ASP A CA 1 ATOM 1573 C C . ASP A 1 193 ? 13.955 -0.988 1.906 1.00 19.38 ? 210 ASP A C 1 ATOM 1574 O O . ASP A 1 193 ? 13.701 -0.286 0.934 1.00 17.55 ? 210 ASP A O 1 ATOM 1575 C CB . ASP A 1 193 ? 16.138 -1.909 0.993 1.00 20.77 ? 210 ASP A CB 1 ATOM 1576 C CG . ASP A 1 193 ? 17.073 -0.965 1.736 1.00 22.18 ? 210 ASP A CG 1 ATOM 1577 O OD1 . ASP A 1 193 ? 16.613 -0.183 2.585 1.00 22.83 ? 210 ASP A OD1 1 ATOM 1578 O OD2 . ASP A 1 193 ? 18.291 -0.986 1.447 1.00 23.61 ? 210 ASP A OD2 1 ATOM 1579 N N . ASP A 1 194 ? 13.489 -0.731 3.129 1.00 19.37 ? 211 ASP A N 1 ATOM 1580 C CA . ASP A 1 194 ? 12.570 0.380 3.379 1.00 20.33 ? 211 ASP A CA 1 ATOM 1581 C C . ASP A 1 194 ? 13.180 1.784 3.222 1.00 20.77 ? 211 ASP A C 1 ATOM 1582 O O . ASP A 1 194 ? 12.433 2.758 3.234 1.00 22.49 ? 211 ASP A O 1 ATOM 1583 C CB . ASP A 1 194 ? 11.917 0.233 4.762 1.00 20.77 ? 211 ASP A CB 1 ATOM 1584 C CG . ASP A 1 194 ? 10.952 -0.933 4.820 1.00 21.65 ? 211 ASP A CG 1 ATOM 1585 O OD1 . ASP A 1 194 ? 10.135 -1.088 3.888 1.00 22.24 ? 211 ASP A OD1 1 ATOM 1586 O OD2 . ASP A 1 194 ? 11.005 -1.694 5.793 1.00 22.16 ? 211 ASP A OD2 1 ATOM 1587 N N . THR A 1 195 ? 14.501 1.902 3.057 1.00 19.38 ? 212 THR A N 1 ATOM 1588 C CA . THR A 1 195 ? 15.099 3.197 2.748 1.00 19.87 ? 212 THR A CA 1 ATOM 1589 C C . THR A 1 195 ? 15.599 3.305 1.303 1.00 19.36 ? 212 THR A C 1 ATOM 1590 O O . THR A 1 195 ? 16.307 4.252 0.985 1.00 18.92 ? 212 THR A O 1 ATOM 1591 C CB . THR A 1 195 ? 16.267 3.536 3.695 1.00 20.04 ? 212 THR A CB 1 ATOM 1592 O OG1 . THR A 1 195 ? 17.364 2.647 3.451 1.00 20.05 ? 212 THR A OG1 1 ATOM 1593 C CG2 . THR A 1 195 ? 15.824 3.448 5.144 1.00 20.97 ? 212 THR A CG2 1 ATOM 1594 N N . PHE A 1 196 ? 15.191 2.381 0.430 1.00 18.67 ? 213 PHE A N 1 ATOM 1595 C CA . PHE A 1 196 ? 15.810 2.253 -0.901 1.00 18.20 ? 213 PHE A CA 1 ATOM 1596 C C . PHE A 1 196 ? 15.643 3.508 -1.747 1.00 18.79 ? 213 PHE A C 1 ATOM 1597 O O . PHE A 1 196 ? 16.584 3.959 -2.396 1.00 18.93 ? 213 PHE A O 1 ATOM 1598 C CB . PHE A 1 196 ? 15.240 1.044 -1.649 1.00 17.90 ? 213 PHE A CB 1 ATOM 1599 C CG . PHE A 1 196 ? 16.088 0.576 -2.799 1.00 17.10 ? 213 PHE A CG 1 ATOM 1600 C CD1 . PHE A 1 196 ? 17.276 -0.104 -2.565 1.00 17.59 ? 213 PHE A CD1 1 ATOM 1601 C CD2 . PHE A 1 196 ? 15.693 0.801 -4.107 1.00 17.24 ? 213 PHE A CD2 1 ATOM 1602 C CE1 . PHE A 1 196 ? 18.062 -0.550 -3.620 1.00 18.02 ? 213 PHE A CE1 1 ATOM 1603 C CE2 . PHE A 1 196 ? 16.471 0.366 -5.169 1.00 17.49 ? 213 PHE A CE2 1 ATOM 1604 C CZ . PHE A 1 196 ? 17.655 -0.318 -4.928 1.00 17.75 ? 213 PHE A CZ 1 ATOM 1605 N N . GLU A 1 197 ? 14.442 4.070 -1.752 1.00 19.69 ? 214 GLU A N 1 ATOM 1606 C CA . GLU A 1 197 ? 14.182 5.258 -2.550 1.00 20.70 ? 214 GLU A CA 1 ATOM 1607 C C . GLU A 1 197 ? 15.027 6.452 -2.062 1.00 20.20 ? 214 GLU A C 1 ATOM 1608 O O . GLU A 1 197 ? 15.594 7.172 -2.871 1.00 18.31 ? 214 GLU A O 1 ATOM 1609 C CB . GLU A 1 197 ? 12.685 5.589 -2.586 1.00 22.18 ? 214 GLU A CB 1 ATOM 1610 C CG . GLU A 1 197 ? 12.298 6.455 -3.781 1.00 23.38 ? 214 GLU A CG 1 ATOM 1611 C CD . GLU A 1 197 ? 12.648 7.916 -3.622 1.00 25.40 ? 214 GLU A CD 1 ATOM 1612 O OE1 . GLU A 1 197 ? 12.666 8.402 -2.464 1.00 25.94 ? 214 GLU A OE1 1 ATOM 1613 O OE2 . GLU A 1 197 ? 12.913 8.583 -4.661 1.00 25.80 ? 214 GLU A OE2 1 ATOM 1614 N N . GLN A 1 198 ? 15.126 6.635 -0.749 1.00 20.79 ? 215 GLN A N 1 ATOM 1615 C CA . GLN A 1 198 ? 15.962 7.701 -0.196 1.00 21.02 ? 215 GLN A CA 1 ATOM 1616 C C . GLN A 1 198 ? 17.439 7.486 -0.527 1.00 21.13 ? 215 GLN A C 1 ATOM 1617 O O . GLN A 1 198 ? 18.143 8.447 -0.809 1.00 19.69 ? 215 GLN A O 1 ATOM 1618 C CB . GLN A 1 198 ? 15.762 7.836 1.324 1.00 22.89 ? 215 GLN A CB 1 ATOM 1619 C CG . GLN A 1 198 ? 16.443 9.054 1.941 1.00 24.43 ? 215 GLN A CG 1 ATOM 1620 C CD . GLN A 1 198 ? 15.978 10.360 1.323 1.00 25.77 ? 215 GLN A CD 1 ATOM 1621 O OE1 . GLN A 1 198 ? 14.784 10.605 1.204 1.00 27.75 ? 215 GLN A OE1 1 ATOM 1622 N NE2 . GLN A 1 198 ? 16.920 11.195 0.909 1.00 27.14 ? 215 GLN A NE2 1 ATOM 1623 N N . GLN A 1 199 ? 17.902 6.230 -0.512 1.00 21.16 ? 216 GLN A N 1 ATOM 1624 C CA . GLN A 1 199 ? 19.285 5.913 -0.899 1.00 20.82 ? 216 GLN A CA 1 ATOM 1625 C C . GLN A 1 199 ? 19.566 6.384 -2.320 1.00 20.90 ? 216 GLN A C 1 ATOM 1626 O O . GLN A 1 199 ? 20.612 6.956 -2.591 1.00 20.68 ? 216 GLN A O 1 ATOM 1627 C CB . GLN A 1 199 ? 19.566 4.408 -0.823 1.00 20.97 ? 216 GLN A CB 1 ATOM 1628 C CG . GLN A 1 199 ? 19.633 3.836 0.578 1.00 20.77 ? 216 GLN A CG 1 ATOM 1629 C CD . GLN A 1 199 ? 19.839 2.340 0.554 1.00 20.83 ? 216 GLN A CD 1 ATOM 1630 O OE1 . GLN A 1 199 ? 20.746 1.841 -0.111 1.00 21.30 ? 216 GLN A OE1 1 ATOM 1631 N NE2 . GLN A 1 199 ? 18.994 1.615 1.263 1.00 20.78 ? 216 GLN A NE2 1 ATOM 1632 N N . LEU A 1 200 ? 18.606 6.154 -3.215 1.00 20.73 ? 217 LEU A N 1 ATOM 1633 C CA . LEU A 1 200 ? 18.704 6.624 -4.592 1.00 20.29 ? 217 LEU A CA 1 ATOM 1634 C C . LEU A 1 200 ? 18.654 8.143 -4.707 1.00 19.96 ? 217 LEU A C 1 ATOM 1635 O O . LEU A 1 200 ? 19.409 8.718 -5.492 1.00 20.98 ? 217 LEU A O 1 ATOM 1636 C CB . LEU A 1 200 ? 17.622 5.970 -5.463 1.00 19.78 ? 217 LEU A CB 1 ATOM 1637 C CG . LEU A 1 200 ? 17.819 4.463 -5.649 1.00 19.55 ? 217 LEU A CG 1 ATOM 1638 C CD1 . LEU A 1 200 ? 16.592 3.844 -6.294 1.00 19.60 ? 217 LEU A CD1 1 ATOM 1639 C CD2 . LEU A 1 200 ? 19.074 4.159 -6.458 1.00 19.51 ? 217 LEU A CD2 1 ATOM 1640 N N . GLU A 1 201 ? 17.791 8.797 -3.934 1.00 20.01 ? 218 GLU A N 1 ATOM 1641 C CA . GLU A 1 201 ? 17.781 10.273 -3.887 1.00 20.97 ? 218 GLU A CA 1 ATOM 1642 C C . GLU A 1 201 ? 19.172 10.816 -3.525 1.00 20.72 ? 218 GLU A C 1 ATOM 1643 O O . GLU A 1 201 ? 19.651 11.764 -4.137 1.00 20.49 ? 218 GLU A O 1 ATOM 1644 C CB . GLU A 1 201 ? 16.760 10.813 -2.879 1.00 20.99 ? 218 GLU A CB 1 ATOM 1645 C CG . GLU A 1 201 ? 15.291 10.535 -3.195 1.00 21.04 ? 218 GLU A CG 1 ATOM 1646 C CD . GLU A 1 201 ? 14.719 11.373 -4.322 1.00 21.38 ? 218 GLU A CD 1 ATOM 1647 O OE1 . GLU A 1 201 ? 15.398 12.271 -4.854 1.00 21.45 ? 218 GLU A OE1 1 ATOM 1648 O OE2 . GLU A 1 201 ? 13.552 11.136 -4.685 1.00 22.07 ? 218 GLU A OE2 1 ATOM 1649 N N . ASP A 1 202 ? 19.803 10.198 -2.531 1.00 21.34 ? 219 ASP A N 1 ATOM 1650 C CA . ASP A 1 202 ? 21.102 10.643 -2.027 1.00 21.82 ? 219 ASP A CA 1 ATOM 1651 C C . ASP A 1 202 ? 22.212 10.456 -3.057 1.00 21.62 ? 219 ASP A C 1 ATOM 1652 O O . ASP A 1 202 ? 23.023 11.359 -3.280 1.00 21.45 ? 219 ASP A O 1 ATOM 1653 C CB . ASP A 1 202 ? 21.460 9.901 -0.734 1.00 22.57 ? 219 ASP A CB 1 ATOM 1654 C CG . ASP A 1 202 ? 20.509 10.219 0.416 1.00 24.17 ? 219 ASP A CG 1 ATOM 1655 O OD1 . ASP A 1 202 ? 19.666 11.131 0.296 1.00 24.82 ? 219 ASP A OD1 1 ATOM 1656 O OD2 . ASP A 1 202 ? 20.589 9.526 1.443 1.00 25.72 ? 219 ASP A OD2 1 ATOM 1657 N N . ILE A 1 203 ? 22.254 9.284 -3.679 1.00 21.13 ? 220 ILE A N 1 ATOM 1658 C CA . ILE A 1 203 ? 23.230 9.017 -4.735 1.00 21.70 ? 220 ILE A CA 1 ATOM 1659 C C . ILE A 1 203 ? 23.005 9.947 -5.934 1.00 22.12 ? 220 ILE A C 1 ATOM 1660 O O . ILE A 1 203 ? 23.961 10.531 -6.468 1.00 22.31 ? 220 ILE A O 1 ATOM 1661 C CB . ILE A 1 203 ? 23.190 7.534 -5.169 1.00 21.31 ? 220 ILE A CB 1 ATOM 1662 C CG1 . ILE A 1 203 ? 23.759 6.659 -4.047 1.00 21.53 ? 220 ILE A CG1 1 ATOM 1663 C CG2 . ILE A 1 203 ? 23.968 7.316 -6.465 1.00 21.83 ? 220 ILE A CG2 1 ATOM 1664 C CD1 . ILE A 1 203 ? 23.352 5.201 -4.123 1.00 21.67 ? 220 ILE A CD1 1 ATOM 1665 N N . PHE A 1 204 ? 21.750 10.093 -6.348 1.00 21.81 ? 221 PHE A N 1 ATOM 1666 C CA . PHE A 1 204 ? 21.431 10.988 -7.444 1.00 22.62 ? 221 PHE A CA 1 ATOM 1667 C C . PHE A 1 204 ? 21.860 12.432 -7.143 1.00 22.36 ? 221 PHE A C 1 ATOM 1668 O O . PHE A 1 204 ? 22.451 13.090 -7.996 1.00 21.74 ? 221 PHE A O 1 ATOM 1669 C CB . PHE A 1 204 ? 19.942 10.952 -7.785 1.00 23.26 ? 221 PHE A CB 1 ATOM 1670 C CG . PHE A 1 204 ? 19.581 11.880 -8.897 1.00 24.05 ? 221 PHE A CG 1 ATOM 1671 C CD1 . PHE A 1 204 ? 19.983 11.601 -10.200 1.00 24.92 ? 221 PHE A CD1 1 ATOM 1672 C CD2 . PHE A 1 204 ? 18.899 13.056 -8.648 1.00 24.50 ? 221 PHE A CD2 1 ATOM 1673 C CE1 . PHE A 1 204 ? 19.679 12.472 -11.236 1.00 25.29 ? 221 PHE A CE1 1 ATOM 1674 C CE2 . PHE A 1 204 ? 18.601 13.928 -9.680 1.00 25.70 ? 221 PHE A CE2 1 ATOM 1675 C CZ . PHE A 1 204 ? 18.994 13.641 -10.972 1.00 25.44 ? 221 PHE A CZ 1 ATOM 1676 N N . ALA A 1 205 ? 21.578 12.905 -5.929 1.00 22.31 ? 222 ALA A N 1 ATOM 1677 C CA . ALA A 1 205 ? 21.976 14.254 -5.526 1.00 22.81 ? 222 ALA A CA 1 ATOM 1678 C C . ALA A 1 205 ? 23.497 14.446 -5.617 1.00 22.59 ? 222 ALA A C 1 ATOM 1679 O O . ALA A 1 205 ? 23.955 15.512 -5.997 1.00 23.93 ? 222 ALA A O 1 ATOM 1680 C CB . ALA A 1 205 ? 21.466 14.583 -4.129 1.00 22.83 ? 222 ALA A CB 1 ATOM 1681 N N . ASP A 1 206 ? 24.268 13.403 -5.318 1.00 23.23 ? 223 ASP A N 1 ATOM 1682 C CA . ASP A 1 206 ? 25.732 13.458 -5.433 1.00 23.16 ? 223 ASP A CA 1 ATOM 1683 C C . ASP A 1 206 ? 26.218 13.558 -6.874 1.00 22.88 ? 223 ASP A C 1 ATOM 1684 O O . ASP A 1 206 ? 27.226 14.202 -7.126 1.00 22.17 ? 223 ASP A O 1 ATOM 1685 C CB . ASP A 1 206 ? 26.390 12.219 -4.802 1.00 24.01 ? 223 ASP A CB 1 ATOM 1686 C CG . ASP A 1 206 ? 26.226 12.157 -3.301 1.00 25.82 ? 223 ASP A CG 1 ATOM 1687 O OD1 . ASP A 1 206 ? 25.886 13.179 -2.670 1.00 26.41 ? 223 ASP A OD1 1 ATOM 1688 O OD2 . ASP A 1 206 ? 26.454 11.059 -2.747 1.00 27.01 ? 223 ASP A OD2 1 ATOM 1689 N N . ILE A 1 207 ? 25.526 12.903 -7.806 1.00 22.91 ? 224 ILE A N 1 ATOM 1690 C CA . ILE A 1 207 ? 25.955 12.869 -9.209 1.00 24.25 ? 224 ILE A CA 1 ATOM 1691 C C . ILE A 1 207 ? 25.339 14.017 -10.021 1.00 23.20 ? 224 ILE A C 1 ATOM 1692 O O . ILE A 1 207 ? 25.844 14.364 -11.085 1.00 22.85 ? 224 ILE A O 1 ATOM 1693 C CB . ILE A 1 207 ? 25.653 11.489 -9.842 1.00 27.54 ? 224 ILE A CB 1 ATOM 1694 C CG1 . ILE A 1 207 ? 26.423 10.395 -9.086 1.00 30.17 ? 224 ILE A CG1 1 ATOM 1695 C CG2 . ILE A 1 207 ? 26.076 11.442 -11.306 1.00 28.20 ? 224 ILE A CG2 1 ATOM 1696 C CD1 . ILE A 1 207 ? 25.816 9.010 -9.215 1.00 31.64 ? 224 ILE A CD1 1 ATOM 1697 N N . ARG A 1 208 ? 24.271 14.618 -9.509 1.00 22.14 ? 225 ARG A N 1 ATOM 1698 C CA . ARG A 1 208 ? 23.550 15.663 -10.229 1.00 23.50 ? 225 ARG A CA 1 ATOM 1699 C C . ARG A 1 208 ? 24.423 16.852 -10.703 1.00 22.54 ? 225 ARG A C 1 ATOM 1700 O O . ARG A 1 208 ? 24.276 17.301 -11.837 1.00 20.38 ? 225 ARG A O 1 ATOM 1701 C CB . ARG A 1 208 ? 22.371 16.151 -9.389 1.00 25.21 ? 225 ARG A CB 1 ATOM 1702 C CG . ARG A 1 208 ? 21.371 16.999 -10.137 1.00 27.31 ? 225 ARG A CG 1 ATOM 1703 C CD . ARG A 1 208 ? 20.087 17.109 -9.333 1.00 29.50 ? 225 ARG A CD 1 ATOM 1704 N NE . ARG A 1 208 ? 18.957 17.554 -10.146 1.00 31.00 ? 225 ARG A NE 1 ATOM 1705 C CZ . ARG A 1 208 ? 17.687 17.601 -9.736 1.00 31.33 ? 225 ARG A CZ 1 ATOM 1706 N NH1 . ARG A 1 208 ? 17.338 17.216 -8.505 1.00 31.69 ? 225 ARG A NH1 1 ATOM 1707 N NH2 . ARG A 1 208 ? 16.754 18.048 -10.567 1.00 31.47 ? 225 ARG A NH2 1 ATOM 1708 N N . PRO A 1 209 ? 25.345 17.349 -9.852 1.00 22.62 ? 226 PRO A N 1 ATOM 1709 C CA . PRO A 1 209 ? 26.226 18.426 -10.340 1.00 22.59 ? 226 PRO A CA 1 ATOM 1710 C C . PRO A 1 209 ? 27.044 18.068 -11.592 1.00 21.90 ? 226 PRO A C 1 ATOM 1711 O O . PRO A 1 209 ? 27.165 18.899 -12.484 1.00 22.59 ? 226 PRO A O 1 ATOM 1712 C CB . PRO A 1 209 ? 27.139 18.713 -9.134 1.00 22.63 ? 226 PRO A CB 1 ATOM 1713 C CG . PRO A 1 209 ? 26.329 18.296 -7.959 1.00 22.78 ? 226 PRO A CG 1 ATOM 1714 C CD . PRO A 1 209 ? 25.586 17.072 -8.426 1.00 22.60 ? 226 PRO A CD 1 ATOM 1715 N N . LEU A 1 210 ? 27.555 16.844 -11.675 1.00 21.64 ? 227 LEU A N 1 ATOM 1716 C CA . LEU A 1 210 ? 28.235 16.377 -12.885 1.00 21.26 ? 227 LEU A CA 1 ATOM 1717 C C . LEU A 1 210 ? 27.279 16.367 -14.078 1.00 20.53 ? 227 LEU A C 1 ATOM 1718 O O . LEU A 1 210 ? 27.658 16.791 -15.170 1.00 20.00 ? 227 LEU A O 1 ATOM 1719 C CB . LEU A 1 210 ? 28.854 14.985 -12.687 1.00 21.62 ? 227 LEU A CB 1 ATOM 1720 C CG . LEU A 1 210 ? 29.547 14.346 -13.900 1.00 22.66 ? 227 LEU A CG 1 ATOM 1721 C CD1 . LEU A 1 210 ? 30.609 15.255 -14.510 1.00 23.07 ? 227 LEU A CD1 1 ATOM 1722 C CD2 . LEU A 1 210 ? 30.170 13.018 -13.506 1.00 23.21 ? 227 LEU A CD2 1 ATOM 1723 N N . TYR A 1 211 ? 26.053 15.878 -13.873 1.00 19.25 ? 228 TYR A N 1 ATOM 1724 C CA . TYR A 1 211 ? 25.038 15.934 -14.932 1.00 19.23 ? 228 TYR A CA 1 ATOM 1725 C C . TYR A 1 211 ? 24.810 17.376 -15.428 1.00 19.69 ? 228 TYR A C 1 ATOM 1726 O O . TYR A 1 211 ? 24.759 17.619 -16.630 1.00 18.24 ? 228 TYR A O 1 ATOM 1727 C CB . TYR A 1 211 ? 23.698 15.340 -14.491 1.00 18.70 ? 228 TYR A CB 1 ATOM 1728 C CG . TYR A 1 211 ? 22.656 15.463 -15.594 1.00 18.29 ? 228 TYR A CG 1 ATOM 1729 C CD1 . TYR A 1 211 ? 22.752 14.696 -16.756 1.00 17.98 ? 228 TYR A CD1 1 ATOM 1730 C CD2 . TYR A 1 211 ? 21.617 16.383 -15.505 1.00 18.04 ? 228 TYR A CD2 1 ATOM 1731 C CE1 . TYR A 1 211 ? 21.824 14.828 -17.784 1.00 17.79 ? 228 TYR A CE1 1 ATOM 1732 C CE2 . TYR A 1 211 ? 20.686 16.522 -16.528 1.00 17.64 ? 228 TYR A CE2 1 ATOM 1733 C CZ . TYR A 1 211 ? 20.789 15.740 -17.663 1.00 17.40 ? 228 TYR A CZ 1 ATOM 1734 O OH . TYR A 1 211 ? 19.869 15.859 -18.684 1.00 16.17 ? 228 TYR A OH 1 ATOM 1735 N N . GLN A 1 212 ? 24.689 18.316 -14.495 1.00 20.78 ? 229 GLN A N 1 ATOM 1736 C CA . GLN A 1 212 ? 24.477 19.735 -14.848 1.00 22.77 ? 229 GLN A CA 1 ATOM 1737 C C . GLN A 1 212 ? 25.602 20.267 -15.723 1.00 21.46 ? 229 GLN A C 1 ATOM 1738 O O . GLN A 1 212 ? 25.345 21.045 -16.642 1.00 21.39 ? 229 GLN A O 1 ATOM 1739 C CB . GLN A 1 212 ? 24.381 20.629 -13.611 1.00 25.61 ? 229 GLN A CB 1 ATOM 1740 C CG . GLN A 1 212 ? 23.317 20.274 -12.588 1.00 28.51 ? 229 GLN A CG 1 ATOM 1741 C CD . GLN A 1 212 ? 21.924 20.333 -13.141 1.00 31.64 ? 229 GLN A CD 1 ATOM 1742 O OE1 . GLN A 1 212 ? 21.449 19.374 -13.751 1.00 35.88 ? 229 GLN A OE1 1 ATOM 1743 N NE2 . GLN A 1 212 ? 21.250 21.457 -12.925 1.00 32.96 ? 229 GLN A NE2 1 ATOM 1744 N N . GLN A 1 213 ? 26.838 19.855 -15.427 1.00 20.51 ? 230 GLN A N 1 ATOM 1745 C CA . GLN A 1 213 ? 28.009 20.259 -16.219 1.00 21.14 ? 230 GLN A CA 1 ATOM 1746 C C . GLN A 1 213 ? 27.953 19.655 -17.624 1.00 20.37 ? 230 GLN A C 1 ATOM 1747 O O . GLN A 1 213 ? 28.242 20.341 -18.609 1.00 20.40 ? 230 GLN A O 1 ATOM 1748 C CB . GLN A 1 213 ? 29.328 19.871 -15.521 1.00 21.35 ? 230 GLN A CB 1 ATOM 1749 C CG . GLN A 1 213 ? 29.587 20.587 -14.189 1.00 22.05 ? 230 GLN A CG 1 ATOM 1750 C CD . GLN A 1 213 ? 29.769 22.094 -14.338 1.00 22.14 ? 230 GLN A CD 1 ATOM 1751 O OE1 . GLN A 1 213 ? 30.570 22.554 -15.157 1.00 21.96 ? 230 GLN A OE1 1 ATOM 1752 N NE2 . GLN A 1 213 ? 29.032 22.866 -13.543 1.00 22.26 ? 230 GLN A NE2 1 ATOM 1753 N N . ILE A 1 214 ? 27.571 18.379 -17.718 1.00 19.58 ? 231 ILE A N 1 ATOM 1754 C CA . ILE A 1 214 ? 27.455 17.700 -19.017 1.00 19.52 ? 231 ILE A CA 1 ATOM 1755 C C . ILE A 1 214 ? 26.332 18.331 -19.830 1.00 18.37 ? 231 ILE A C 1 ATOM 1756 O O . ILE A 1 214 ? 26.502 18.648 -21.007 1.00 18.57 ? 231 ILE A O 1 ATOM 1757 C CB . ILE A 1 214 ? 27.202 16.176 -18.865 1.00 19.71 ? 231 ILE A CB 1 ATOM 1758 C CG1 . ILE A 1 214 ? 28.425 15.495 -18.250 1.00 20.34 ? 231 ILE A CG1 1 ATOM 1759 C CG2 . ILE A 1 214 ? 26.877 15.537 -20.218 1.00 19.55 ? 231 ILE A CG2 1 ATOM 1760 C CD1 . ILE A 1 214 ? 28.151 14.101 -17.712 1.00 20.97 ? 231 ILE A CD1 1 ATOM 1761 N N . HIS A 1 215 ? 25.189 18.511 -19.188 1.00 18.18 ? 232 HIS A N 1 ATOM 1762 C CA . HIS A 1 215 ? 24.047 19.179 -19.806 1.00 18.11 ? 232 HIS A CA 1 ATOM 1763 C C . HIS A 1 215 ? 24.433 20.545 -20.383 1.00 17.93 ? 232 HIS A C 1 ATOM 1764 O O . HIS A 1 215 ? 24.112 20.848 -21.523 1.00 18.24 ? 232 HIS A O 1 ATOM 1765 C CB . HIS A 1 215 ? 22.940 19.345 -18.766 1.00 17.80 ? 232 HIS A CB 1 ATOM 1766 C CG . HIS A 1 215 ? 21.745 20.087 -19.257 1.00 18.00 ? 232 HIS A CG 1 ATOM 1767 N ND1 . HIS A 1 215 ? 21.708 21.462 -19.354 1.00 18.08 ? 232 HIS A ND1 1 ATOM 1768 C CD2 . HIS A 1 215 ? 20.529 19.647 -19.660 1.00 17.88 ? 232 HIS A CD2 1 ATOM 1769 C CE1 . HIS A 1 215 ? 20.522 21.833 -19.803 1.00 18.11 ? 232 HIS A CE1 1 ATOM 1770 N NE2 . HIS A 1 215 ? 19.789 20.751 -19.993 1.00 17.87 ? 232 HIS A NE2 1 ATOM 1771 N N . GLY A 1 216 ? 25.092 21.365 -19.576 1.00 18.55 ? 233 GLY A N 1 ATOM 1772 C CA . GLY A 1 216 ? 25.487 22.716 -19.990 1.00 18.60 ? 233 GLY A CA 1 ATOM 1773 C C . GLY A 1 216 ? 26.414 22.698 -21.194 1.00 18.98 ? 233 GLY A C 1 ATOM 1774 O O . GLY A 1 216 ? 26.200 23.430 -22.170 1.00 19.95 ? 233 GLY A O 1 ATOM 1775 N N . TYR A 1 217 ? 27.423 21.833 -21.150 1.00 18.97 ? 234 TYR A N 1 ATOM 1776 C CA . TYR A 1 217 ? 28.357 21.708 -22.265 1.00 19.67 ? 234 TYR A CA 1 ATOM 1777 C C . TYR A 1 217 ? 27.669 21.252 -23.563 1.00 19.53 ? 234 TYR A C 1 ATOM 1778 O O . TYR A 1 217 ? 27.899 21.826 -24.642 1.00 19.58 ? 234 TYR A O 1 ATOM 1779 C CB . TYR A 1 217 ? 29.499 20.760 -21.921 1.00 20.14 ? 234 TYR A CB 1 ATOM 1780 C CG . TYR A 1 217 ? 30.579 20.802 -22.961 1.00 21.40 ? 234 TYR A CG 1 ATOM 1781 C CD1 . TYR A 1 217 ? 31.427 21.911 -23.063 1.00 22.92 ? 234 TYR A CD1 1 ATOM 1782 C CD2 . TYR A 1 217 ? 30.739 19.764 -23.875 1.00 22.08 ? 234 TYR A CD2 1 ATOM 1783 C CE1 . TYR A 1 217 ? 32.424 21.965 -24.025 1.00 23.51 ? 234 TYR A CE1 1 ATOM 1784 C CE2 . TYR A 1 217 ? 31.735 19.806 -24.837 1.00 23.59 ? 234 TYR A CE2 1 ATOM 1785 C CZ . TYR A 1 217 ? 32.578 20.907 -24.905 1.00 24.01 ? 234 TYR A CZ 1 ATOM 1786 O OH . TYR A 1 217 ? 33.554 20.951 -25.871 1.00 25.95 ? 234 TYR A OH 1 ATOM 1787 N N . VAL A 1 218 ? 26.819 20.237 -23.462 1.00 18.38 ? 235 VAL A N 1 ATOM 1788 C CA . VAL A 1 218 ? 26.071 19.769 -24.628 1.00 18.34 ? 235 VAL A CA 1 ATOM 1789 C C . VAL A 1 218 ? 25.173 20.870 -25.215 1.00 18.74 ? 235 VAL A C 1 ATOM 1790 O O . VAL A 1 218 ? 25.153 21.074 -26.429 1.00 18.61 ? 235 VAL A O 1 ATOM 1791 C CB . VAL A 1 218 ? 25.257 18.496 -24.297 1.00 18.44 ? 235 VAL A CB 1 ATOM 1792 C CG1 . VAL A 1 218 ? 24.267 18.165 -25.406 1.00 18.12 ? 235 VAL A CG1 1 ATOM 1793 C CG2 . VAL A 1 218 ? 26.213 17.336 -24.059 1.00 18.29 ? 235 VAL A CG2 1 ATOM 1794 N N . ARG A 1 219 ? 24.440 21.579 -24.362 1.00 18.81 ? 236 ARG A N 1 ATOM 1795 C CA . ARG A 1 219 ? 23.615 22.702 -24.826 1.00 20.22 ? 236 ARG A CA 1 ATOM 1796 C C . ARG A 1 219 ? 24.452 23.783 -25.531 1.00 20.72 ? 236 ARG A C 1 ATOM 1797 O O . ARG A 1 219 ? 24.061 24.307 -26.579 1.00 20.05 ? 236 ARG A O 1 ATOM 1798 C CB . ARG A 1 219 ? 22.851 23.313 -23.656 1.00 20.28 ? 236 ARG A CB 1 ATOM 1799 C CG . ARG A 1 219 ? 22.006 24.536 -24.014 1.00 20.52 ? 236 ARG A CG 1 ATOM 1800 C CD . ARG A 1 219 ? 21.155 24.989 -22.846 1.00 20.46 ? 236 ARG A CD 1 ATOM 1801 N NE . ARG A 1 219 ? 21.955 25.219 -21.652 1.00 20.79 ? 236 ARG A NE 1 ATOM 1802 C CZ . ARG A 1 219 ? 21.462 25.492 -20.447 1.00 20.94 ? 236 ARG A CZ 1 ATOM 1803 N NH1 . ARG A 1 219 ? 20.154 25.606 -20.248 1.00 21.03 ? 236 ARG A NH1 1 ATOM 1804 N NH2 . ARG A 1 219 ? 22.301 25.675 -19.429 1.00 21.73 ? 236 ARG A NH2 1 ATOM 1805 N N . PHE A 1 220 ? 25.593 24.102 -24.934 1.00 21.80 ? 237 PHE A N 1 ATOM 1806 C CA . PHE A 1 220 ? 26.542 25.078 -25.488 1.00 23.44 ? 237 PHE A CA 1 ATOM 1807 C C . PHE A 1 220 ? 26.955 24.648 -26.905 1.00 22.70 ? 237 PHE A C 1 ATOM 1808 O O . PHE A 1 220 ? 26.856 25.434 -27.853 1.00 22.12 ? 237 PHE A O 1 ATOM 1809 C CB . PHE A 1 220 ? 27.731 25.225 -24.511 1.00 24.91 ? 237 PHE A CB 1 ATOM 1810 C CG . PHE A 1 220 ? 28.960 25.864 -25.093 1.00 27.31 ? 237 PHE A CG 1 ATOM 1811 C CD1 . PHE A 1 220 ? 29.050 27.247 -25.224 1.00 29.98 ? 237 PHE A CD1 1 ATOM 1812 C CD2 . PHE A 1 220 ? 30.052 25.086 -25.459 1.00 29.24 ? 237 PHE A CD2 1 ATOM 1813 C CE1 . PHE A 1 220 ? 30.199 27.839 -25.746 1.00 31.34 ? 237 PHE A CE1 1 ATOM 1814 C CE2 . PHE A 1 220 ? 31.203 25.669 -25.986 1.00 31.31 ? 237 PHE A CE2 1 ATOM 1815 C CZ . PHE A 1 220 ? 31.277 27.046 -26.127 1.00 30.98 ? 237 PHE A CZ 1 ATOM 1816 N N . ARG A 1 221 ? 27.338 23.382 -27.053 1.00 21.58 ? 238 ARG A N 1 ATOM 1817 C CA . ARG A 1 221 ? 27.762 22.841 -28.348 1.00 21.66 ? 238 ARG A CA 1 ATOM 1818 C C . ARG A 1 221 ? 26.631 22.686 -29.370 1.00 21.22 ? 238 ARG A C 1 ATOM 1819 O O . ARG A 1 221 ? 26.845 22.899 -30.575 1.00 21.04 ? 238 ARG A O 1 ATOM 1820 C CB . ARG A 1 221 ? 28.513 21.518 -28.158 1.00 22.07 ? 238 ARG A CB 1 ATOM 1821 C CG . ARG A 1 221 ? 29.841 21.660 -27.416 1.00 22.37 ? 238 ARG A CG 1 ATOM 1822 C CD . ARG A 1 221 ? 30.911 22.367 -28.250 1.00 23.65 ? 238 ARG A CD 1 ATOM 1823 N NE . ARG A 1 221 ? 31.204 21.575 -29.442 1.00 24.18 ? 238 ARG A NE 1 ATOM 1824 C CZ . ARG A 1 221 ? 32.121 20.614 -29.533 1.00 24.92 ? 238 ARG A CZ 1 ATOM 1825 N NH1 . ARG A 1 221 ? 32.925 20.324 -28.516 1.00 26.22 ? 238 ARG A NH1 1 ATOM 1826 N NH2 . ARG A 1 221 ? 32.242 19.937 -30.670 1.00 25.64 ? 238 ARG A NH2 1 ATOM 1827 N N . LEU A 1 222 ? 25.443 22.301 -28.909 1.00 20.42 ? 239 LEU A N 1 ATOM 1828 C CA . LEU A 1 222 ? 24.251 22.270 -29.769 1.00 19.94 ? 239 LEU A CA 1 ATOM 1829 C C . LEU A 1 222 ? 23.866 23.655 -30.288 1.00 21.00 ? 239 LEU A C 1 ATOM 1830 O O . LEU A 1 222 ? 23.494 23.807 -31.460 1.00 20.33 ? 239 LEU A O 1 ATOM 1831 C CB . LEU A 1 222 ? 23.056 21.650 -29.036 1.00 19.49 ? 239 LEU A CB 1 ATOM 1832 C CG . LEU A 1 222 ? 23.091 20.122 -28.866 1.00 18.76 ? 239 LEU A CG 1 ATOM 1833 C CD1 . LEU A 1 222 ? 21.934 19.705 -27.970 1.00 19.38 ? 239 LEU A CD1 1 ATOM 1834 C CD2 . LEU A 1 222 ? 23.051 19.396 -30.205 1.00 19.00 ? 239 LEU A CD2 1 ATOM 1835 N N . ARG A 1 223 ? 23.958 24.652 -29.417 1.00 21.89 ? 240 ARG A N 1 ATOM 1836 C CA . ARG A 1 223 ? 23.685 26.034 -29.799 1.00 25.10 ? 240 ARG A CA 1 ATOM 1837 C C . ARG A 1 223 ? 24.690 26.561 -30.839 1.00 25.52 ? 240 ARG A C 1 ATOM 1838 O O . ARG A 1 223 ? 24.307 27.275 -31.775 1.00 23.95 ? 240 ARG A O 1 ATOM 1839 C CB . ARG A 1 223 ? 23.676 26.905 -28.541 1.00 26.71 ? 240 ARG A CB 1 ATOM 1840 C CG . ARG A 1 223 ? 23.279 28.355 -28.745 1.00 30.16 ? 240 ARG A CG 1 ATOM 1841 C CD . ARG A 1 223 ? 22.950 28.972 -27.395 1.00 32.62 ? 240 ARG A CD 1 ATOM 1842 N NE . ARG A 1 223 ? 22.874 30.429 -27.426 1.00 36.97 ? 240 ARG A NE 1 ATOM 1843 C CZ . ARG A 1 223 ? 23.922 31.253 -27.345 1.00 38.77 ? 240 ARG A CZ 1 ATOM 1844 N NH1 . ARG A 1 223 ? 25.168 30.794 -27.254 1.00 40.90 ? 240 ARG A NH1 1 ATOM 1845 N NH2 . ARG A 1 223 ? 23.721 32.566 -27.368 1.00 41.78 ? 240 ARG A NH2 1 ATOM 1846 N N . LYS A 1 224 ? 25.958 26.193 -30.682 1.00 26.41 ? 241 LYS A N 1 ATOM 1847 C CA . LYS A 1 224 ? 26.989 26.540 -31.664 1.00 29.09 ? 241 LYS A CA 1 ATOM 1848 C C . LYS A 1 224 ? 26.730 25.894 -33.022 1.00 28.15 ? 241 LYS A C 1 ATOM 1849 O O . LYS A 1 224 ? 27.069 26.476 -34.055 1.00 28.76 ? 241 LYS A O 1 ATOM 1850 C CB . LYS A 1 224 ? 28.375 26.136 -31.162 1.00 32.29 ? 241 LYS A CB 1 ATOM 1851 C CG . LYS A 1 224 ? 28.838 26.937 -29.951 1.00 35.81 ? 241 LYS A CG 1 ATOM 1852 C CD . LYS A 1 224 ? 29.964 27.916 -30.251 1.00 39.98 ? 241 LYS A CD 1 ATOM 1853 C CE . LYS A 1 224 ? 31.240 27.227 -30.724 1.00 43.97 ? 241 LYS A CE 1 ATOM 1854 N NZ . LYS A 1 224 ? 31.552 25.944 -30.026 1.00 47.06 ? 241 LYS A NZ 1 ATOM 1855 N N . HIS A 1 225 ? 26.145 24.698 -33.024 1.00 25.83 ? 242 HIS A N 1 ATOM 1856 C CA . HIS A 1 225 ? 25.775 24.033 -34.271 1.00 25.73 ? 242 HIS A CA 1 ATOM 1857 C C . HIS A 1 225 ? 24.469 24.550 -34.886 1.00 25.67 ? 242 HIS A C 1 ATOM 1858 O O . HIS A 1 225 ? 24.412 24.801 -36.090 1.00 26.26 ? 242 HIS A O 1 ATOM 1859 C CB . HIS A 1 225 ? 25.675 22.519 -34.093 1.00 25.68 ? 242 HIS A CB 1 ATOM 1860 C CG . HIS A 1 225 ? 25.380 21.810 -35.372 1.00 27.39 ? 242 HIS A CG 1 ATOM 1861 N ND1 . HIS A 1 225 ? 26.341 21.596 -36.337 1.00 28.87 ? 242 HIS A ND1 1 ATOM 1862 C CD2 . HIS A 1 225 ? 24.220 21.337 -35.881 1.00 27.67 ? 242 HIS A CD2 1 ATOM 1863 C CE1 . HIS A 1 225 ? 25.788 20.987 -37.373 1.00 29.55 ? 242 HIS A CE1 1 ATOM 1864 N NE2 . HIS A 1 225 ? 24.504 20.816 -37.119 1.00 29.53 ? 242 HIS A NE2 1 ATOM 1865 N N . TYR A 1 226 ? 23.427 24.687 -34.068 1.00 23.79 ? 243 TYR A N 1 ATOM 1866 C CA . TYR A 1 226 ? 22.075 24.948 -34.560 1.00 23.28 ? 243 TYR A CA 1 ATOM 1867 C C . TYR A 1 226 ? 21.654 26.418 -34.501 1.00 24.58 ? 243 TYR A C 1 ATOM 1868 O O . TYR A 1 226 ? 20.718 26.796 -35.194 1.00 24.80 ? 243 TYR A O 1 ATOM 1869 C CB . TYR A 1 226 ? 21.056 24.096 -33.798 1.00 21.97 ? 243 TYR A CB 1 ATOM 1870 C CG . TYR A 1 226 ? 21.038 22.625 -34.162 1.00 20.83 ? 243 TYR A CG 1 ATOM 1871 C CD1 . TYR A 1 226 ? 20.453 22.196 -35.345 1.00 20.88 ? 243 TYR A CD1 1 ATOM 1872 C CD2 . TYR A 1 226 ? 21.555 21.654 -33.297 1.00 20.75 ? 243 TYR A CD2 1 ATOM 1873 C CE1 . TYR A 1 226 ? 20.391 20.850 -35.676 1.00 19.98 ? 243 TYR A CE1 1 ATOM 1874 C CE2 . TYR A 1 226 ? 21.509 20.300 -33.628 1.00 20.25 ? 243 TYR A CE2 1 ATOM 1875 C CZ . TYR A 1 226 ? 20.923 19.906 -34.824 1.00 19.96 ? 243 TYR A CZ 1 ATOM 1876 O OH . TYR A 1 226 ? 20.851 18.573 -35.169 1.00 19.02 ? 243 TYR A OH 1 ATOM 1877 N N . GLY A 1 227 ? 22.338 27.228 -33.690 1.00 25.52 ? 244 GLY A N 1 ATOM 1878 C CA . GLY A 1 227 ? 21.998 28.642 -33.500 1.00 26.32 ? 244 GLY A CA 1 ATOM 1879 C C . GLY A 1 227 ? 20.985 28.877 -32.398 1.00 28.49 ? 244 GLY A C 1 ATOM 1880 O O . GLY A 1 227 ? 20.305 27.944 -31.945 1.00 26.28 ? 244 GLY A O 1 ATOM 1881 N N . ASP A 1 228 ? 20.875 30.142 -31.987 1.00 29.72 ? 245 ASP A N 1 ATOM 1882 C CA . ASP A 1 228 ? 20.016 30.561 -30.866 1.00 33.49 ? 245 ASP A CA 1 ATOM 1883 C C . ASP A 1 228 ? 18.519 30.336 -31.008 1.00 31.23 ? 245 ASP A C 1 ATOM 1884 O O . ASP A 1 228 ? 17.846 30.047 -30.020 1.00 31.15 ? 245 ASP A O 1 ATOM 1885 C CB . ASP A 1 228 ? 20.218 32.053 -30.561 1.00 37.54 ? 245 ASP A CB 1 ATOM 1886 C CG . ASP A 1 228 ? 21.037 32.272 -29.342 1.00 42.95 ? 245 ASP A CG 1 ATOM 1887 O OD1 . ASP A 1 228 ? 20.522 31.992 -28.227 1.00 46.93 ? 245 ASP A OD1 1 ATOM 1888 O OD2 . ASP A 1 228 ? 22.193 32.718 -29.492 1.00 47.24 ? 245 ASP A OD2 1 ATOM 1889 N N . ALA A 1 229 ? 18.000 30.508 -32.219 1.00 30.10 ? 246 ALA A N 1 ATOM 1890 C CA . ALA A 1 229 ? 16.577 30.339 -32.477 1.00 29.66 ? 246 ALA A CA 1 ATOM 1891 C C . ALA A 1 229 ? 16.133 28.886 -32.279 1.00 28.48 ? 246 ALA A C 1 ATOM 1892 O O . ALA A 1 229 ? 14.980 28.633 -31.909 1.00 29.98 ? 246 ALA A O 1 ATOM 1893 C CB . ALA A 1 229 ? 16.233 30.814 -33.877 1.00 30.47 ? 246 ALA A CB 1 ATOM 1894 N N . VAL A 1 230 ? 17.053 27.949 -32.508 1.00 26.00 ? 247 VAL A N 1 ATOM 1895 C CA . VAL A 1 230 ? 16.778 26.516 -32.376 1.00 25.31 ? 247 VAL A CA 1 ATOM 1896 C C . VAL A 1 230 ? 17.105 26.017 -30.960 1.00 24.40 ? 247 VAL A C 1 ATOM 1897 O O . VAL A 1 230 ? 16.339 25.234 -30.407 1.00 24.18 ? 247 VAL A O 1 ATOM 1898 C CB . VAL A 1 230 ? 17.552 25.699 -33.446 1.00 24.67 ? 247 VAL A CB 1 ATOM 1899 C CG1 . VAL A 1 230 ? 17.349 24.203 -33.263 1.00 24.49 ? 247 VAL A CG1 1 ATOM 1900 C CG2 . VAL A 1 230 ? 17.116 26.114 -34.848 1.00 25.72 ? 247 VAL A CG2 1 ATOM 1901 N N . VAL A 1 231 ? 18.241 26.450 -30.406 1.00 23.72 ? 248 VAL A N 1 ATOM 1902 C CA . VAL A 1 231 ? 18.684 26.077 -29.046 1.00 23.22 ? 248 VAL A CA 1 ATOM 1903 C C . VAL A 1 231 ? 18.987 27.325 -28.213 1.00 24.65 ? 248 VAL A C 1 ATOM 1904 O O . VAL A 1 231 ? 19.999 28.006 -28.448 1.00 23.90 ? 248 VAL A O 1 ATOM 1905 C CB . VAL A 1 231 ? 19.958 25.203 -29.091 1.00 22.95 ? 248 VAL A CB 1 ATOM 1906 C CG1 . VAL A 1 231 ? 20.354 24.731 -27.690 1.00 23.01 ? 248 VAL A CG1 1 ATOM 1907 C CG2 . VAL A 1 231 ? 19.756 24.011 -30.018 1.00 22.37 ? 248 VAL A CG2 1 ATOM 1908 N N . SER A 1 232 ? 18.124 27.621 -27.237 1.00 25.37 ? 249 SER A N 1 ATOM 1909 C CA . SER A 1 232 ? 18.331 28.787 -26.376 1.00 27.07 ? 249 SER A CA 1 ATOM 1910 C C . SER A 1 232 ? 19.484 28.530 -25.395 1.00 26.84 ? 249 SER A C 1 ATOM 1911 O O . SER A 1 232 ? 19.784 27.382 -25.057 1.00 25.27 ? 249 SER A O 1 ATOM 1912 C CB . SER A 1 232 ? 17.038 29.187 -25.652 1.00 28.01 ? 249 SER A CB 1 ATOM 1913 O OG . SER A 1 232 ? 16.850 28.467 -24.456 1.00 30.07 ? 249 SER A OG 1 ATOM 1914 N N . GLU A 1 233 ? 20.130 29.611 -24.965 1.00 26.70 ? 250 GLU A N 1 ATOM 1915 C CA . GLU A 1 233 ? 21.253 29.548 -24.044 1.00 28.16 ? 250 GLU A CA 1 ATOM 1916 C C . GLU A 1 233 ? 20.842 29.085 -22.649 1.00 26.20 ? 250 GLU A C 1 ATOM 1917 O O . GLU A 1 233 ? 21.615 28.427 -21.965 1.00 26.34 ? 250 GLU A O 1 ATOM 1918 C CB . GLU A 1 233 ? 21.917 30.936 -23.924 1.00 31.00 ? 250 GLU A CB 1 ATOM 1919 C CG . GLU A 1 233 ? 23.138 30.963 -23.014 1.00 34.78 ? 250 GLU A CG 1 ATOM 1920 C CD . GLU A 1 233 ? 23.849 32.307 -22.975 1.00 37.75 ? 250 GLU A CD 1 ATOM 1921 O OE1 . GLU A 1 233 ? 23.296 33.314 -23.470 1.00 39.10 ? 250 GLU A OE1 1 ATOM 1922 O OE2 . GLU A 1 233 ? 24.971 32.338 -22.429 1.00 40.06 ? 250 GLU A OE2 1 ATOM 1923 N N . THR A 1 234 ? 19.655 29.489 -22.217 1.00 25.45 ? 251 THR A N 1 ATOM 1924 C CA . THR A 1 234 ? 19.232 29.313 -20.836 1.00 25.92 ? 251 THR A CA 1 ATOM 1925 C C . THR A 1 234 ? 18.068 28.345 -20.647 1.00 24.01 ? 251 THR A C 1 ATOM 1926 O O . THR A 1 234 ? 17.759 28.003 -19.509 1.00 24.52 ? 251 THR A O 1 ATOM 1927 C CB . THR A 1 234 ? 18.842 30.676 -20.218 1.00 26.95 ? 251 THR A CB 1 ATOM 1928 O OG1 . THR A 1 234 ? 17.738 31.231 -20.937 1.00 29.73 ? 251 THR A OG1 1 ATOM 1929 C CG2 . THR A 1 234 ? 20.017 31.638 -20.268 1.00 28.44 ? 251 THR A CG2 1 ATOM 1930 N N . GLY A 1 235 ? 17.433 27.904 -21.736 1.00 21.81 ? 252 GLY A N 1 ATOM 1931 C CA . GLY A 1 235 ? 16.240 27.057 -21.645 1.00 21.24 ? 252 GLY A CA 1 ATOM 1932 C C . GLY A 1 235 ? 16.600 25.576 -21.619 1.00 19.64 ? 252 GLY A C 1 ATOM 1933 O O . GLY A 1 235 ? 17.764 25.220 -21.834 1.00 18.76 ? 252 GLY A O 1 ATOM 1934 N N . PRO A 1 236 ? 15.605 24.705 -21.347 1.00 18.83 ? 253 PRO A N 1 ATOM 1935 C CA . PRO A 1 236 ? 15.833 23.259 -21.478 1.00 18.15 ? 253 PRO A CA 1 ATOM 1936 C C . PRO A 1 236 ? 16.222 22.895 -22.922 1.00 18.34 ? 253 PRO A C 1 ATOM 1937 O O . PRO A 1 236 ? 15.820 23.586 -23.869 1.00 18.28 ? 253 PRO A O 1 ATOM 1938 C CB . PRO A 1 236 ? 14.477 22.650 -21.096 1.00 18.41 ? 253 PRO A CB 1 ATOM 1939 C CG . PRO A 1 236 ? 13.746 23.726 -20.352 1.00 18.99 ? 253 PRO A CG 1 ATOM 1940 C CD . PRO A 1 236 ? 14.208 25.002 -20.981 1.00 18.62 ? 253 PRO A CD 1 ATOM 1941 N N . ILE A 1 237 ? 16.996 21.825 -23.093 1.00 17.61 ? 254 ILE A N 1 ATOM 1942 C CA . ILE A 1 237 ? 17.440 21.427 -24.423 1.00 17.24 ? 254 ILE A CA 1 ATOM 1943 C C . ILE A 1 237 ? 16.255 20.819 -25.178 1.00 17.44 ? 254 ILE A C 1 ATOM 1944 O O . ILE A 1 237 ? 15.573 19.951 -24.637 1.00 16.79 ? 254 ILE A O 1 ATOM 1945 C CB . ILE A 1 237 ? 18.576 20.394 -24.370 1.00 17.44 ? 254 ILE A CB 1 ATOM 1946 C CG1 . ILE A 1 237 ? 19.770 20.972 -23.613 1.00 17.04 ? 254 ILE A CG1 1 ATOM 1947 C CG2 . ILE A 1 237 ? 18.964 19.960 -25.790 1.00 17.32 ? 254 ILE A CG2 1 ATOM 1948 C CD1 . ILE A 1 237 ? 20.861 19.973 -23.310 1.00 17.42 ? 254 ILE A CD1 1 ATOM 1949 N N . PRO A 1 238 ? 15.993 21.294 -26.417 1.00 17.59 ? 255 PRO A N 1 ATOM 1950 C CA . PRO A 1 238 ? 15.028 20.622 -27.275 1.00 17.41 ? 255 PRO A CA 1 ATOM 1951 C C . PRO A 1 238 ? 15.456 19.164 -27.501 1.00 17.23 ? 255 PRO A C 1 ATOM 1952 O O . PRO A 1 238 ? 16.529 18.904 -28.034 1.00 16.29 ? 255 PRO A O 1 ATOM 1953 C CB . PRO A 1 238 ? 15.054 21.451 -28.563 1.00 17.64 ? 255 PRO A CB 1 ATOM 1954 C CG . PRO A 1 238 ? 15.577 22.776 -28.163 1.00 18.15 ? 255 PRO A CG 1 ATOM 1955 C CD . PRO A 1 238 ? 16.553 22.501 -27.066 1.00 17.91 ? 255 PRO A CD 1 ATOM 1956 N N . MET A 1 239 ? 14.623 18.235 -27.039 1.00 16.55 ? 256 MET A N 1 ATOM 1957 C CA . MET A 1 239 ? 15.048 16.838 -26.873 1.00 16.02 ? 256 MET A CA 1 ATOM 1958 C C . MET A 1 239 ? 15.280 16.089 -28.179 1.00 15.94 ? 256 MET A C 1 ATOM 1959 O O . MET A 1 239 ? 16.019 15.107 -28.212 1.00 15.97 ? 256 MET A O 1 ATOM 1960 C CB . MET A 1 239 ? 14.036 16.078 -26.024 1.00 15.92 ? 256 MET A CB 1 ATOM 1961 C CG . MET A 1 239 ? 12.679 15.861 -26.671 1.00 15.66 ? 256 MET A CG 1 ATOM 1962 S SD . MET A 1 239 ? 11.527 15.151 -25.492 1.00 15.85 ? 256 MET A SD 1 ATOM 1963 C CE . MET A 1 239 ? 12.275 13.568 -25.107 1.00 15.87 ? 256 MET A CE 1 ATOM 1964 N N . HIS A 1 240 ? 14.593 16.524 -29.226 1.00 16.25 ? 257 HIS A N 1 ATOM 1965 C CA . HIS A 1 240 ? 14.753 15.979 -30.579 1.00 16.62 ? 257 HIS A CA 1 ATOM 1966 C C . HIS A 1 240 ? 16.133 16.135 -31.207 1.00 16.18 ? 257 HIS A C 1 ATOM 1967 O O . HIS A 1 240 ? 16.408 15.497 -32.220 1.00 16.11 ? 257 HIS A O 1 ATOM 1968 C CB . HIS A 1 240 ? 13.666 16.529 -31.525 1.00 17.02 ? 257 HIS A CB 1 ATOM 1969 C CG . HIS A 1 240 ? 13.818 17.981 -31.891 1.00 17.79 ? 257 HIS A CG 1 ATOM 1970 N ND1 . HIS A 1 240 ? 14.030 18.983 -30.965 1.00 17.82 ? 257 HIS A ND1 1 ATOM 1971 C CD2 . HIS A 1 240 ? 13.714 18.602 -33.091 1.00 17.45 ? 257 HIS A CD2 1 ATOM 1972 C CE1 . HIS A 1 240 ? 14.078 20.150 -31.583 1.00 17.63 ? 257 HIS A CE1 1 ATOM 1973 N NE2 . HIS A 1 240 ? 13.882 19.947 -32.872 1.00 17.46 ? 257 HIS A NE2 1 ATOM 1974 N N . LEU A 1 241 ? 16.977 16.980 -30.618 1.00 16.11 ? 258 LEU A N 1 ATOM 1975 C CA . LEU A 1 241 ? 18.348 17.191 -31.074 1.00 16.62 ? 258 LEU A CA 1 ATOM 1976 C C . LEU A 1 241 ? 19.369 16.327 -30.338 1.00 16.68 ? 258 LEU A C 1 ATOM 1977 O O . LEU A 1 241 ? 20.567 16.451 -30.596 1.00 16.40 ? 258 LEU A O 1 ATOM 1978 C CB . LEU A 1 241 ? 18.724 18.664 -30.874 1.00 17.14 ? 258 LEU A CB 1 ATOM 1979 C CG . LEU A 1 241 ? 17.734 19.691 -31.432 1.00 17.47 ? 258 LEU A CG 1 ATOM 1980 C CD1 . LEU A 1 241 ? 18.208 21.096 -31.104 1.00 18.18 ? 258 LEU A CD1 1 ATOM 1981 C CD2 . LEU A 1 241 ? 17.525 19.516 -32.923 1.00 18.14 ? 258 LEU A CD2 1 ATOM 1982 N N . LEU A 1 242 ? 18.914 15.465 -29.424 1.00 16.37 ? 259 LEU A N 1 ATOM 1983 C CA . LEU A 1 242 ? 19.830 14.677 -28.595 1.00 16.48 ? 259 LEU A CA 1 ATOM 1984 C C . LEU A 1 242 ? 20.064 13.246 -29.092 1.00 17.09 ? 259 LEU A C 1 ATOM 1985 O O . LEU A 1 242 ? 20.711 12.465 -28.399 1.00 18.00 ? 259 LEU A O 1 ATOM 1986 C CB . LEU A 1 242 ? 19.354 14.695 -27.137 1.00 16.36 ? 259 LEU A CB 1 ATOM 1987 C CG . LEU A 1 242 ? 19.417 16.090 -26.502 1.00 16.19 ? 259 LEU A CG 1 ATOM 1988 C CD1 . LEU A 1 242 ? 18.565 16.151 -25.247 1.00 16.02 ? 259 LEU A CD1 1 ATOM 1989 C CD2 . LEU A 1 242 ? 20.853 16.487 -26.210 1.00 16.82 ? 259 LEU A CD2 1 ATOM 1990 N N . GLY A 1 243 ? 19.565 12.904 -30.284 1.00 17.16 ? 260 GLY A N 1 ATOM 1991 C CA . GLY A 1 243 ? 19.943 11.651 -30.943 1.00 17.61 ? 260 GLY A CA 1 ATOM 1992 C C . GLY A 1 243 ? 19.191 10.401 -30.517 1.00 17.62 ? 260 GLY A C 1 ATOM 1993 O O . GLY A 1 243 ? 19.501 9.306 -30.982 1.00 18.74 ? 260 GLY A O 1 ATOM 1994 N N . ASN A 1 244 ? 18.210 10.562 -29.633 1.00 17.38 ? 261 ASN A N 1 ATOM 1995 C CA . ASN A 1 244 ? 17.448 9.454 -29.082 1.00 17.17 ? 261 ASN A CA 1 ATOM 1996 C C . ASN A 1 244 ? 16.015 9.941 -28.877 1.00 16.52 ? 261 ASN A C 1 ATOM 1997 O O . ASN A 1 244 ? 15.803 11.048 -28.391 1.00 15.40 ? 261 ASN A O 1 ATOM 1998 C CB . ASN A 1 244 ? 18.105 9.004 -27.758 1.00 17.65 ? 261 ASN A CB 1 ATOM 1999 C CG . ASN A 1 244 ? 17.330 7.902 -27.052 1.00 18.02 ? 261 ASN A CG 1 ATOM 2000 O OD1 . ASN A 1 244 ? 16.382 8.170 -26.301 1.00 17.21 ? 261 ASN A OD1 1 ATOM 2001 N ND2 . ASN A 1 244 ? 17.730 6.652 -27.288 1.00 17.66 ? 261 ASN A ND2 1 ATOM 2002 N N . MET A 1 245 ? 15.042 9.112 -29.237 1.00 16.33 ? 262 MET A N 1 ATOM 2003 C CA . MET A 1 245 ? 13.623 9.500 -29.210 1.00 16.56 ? 262 MET A CA 1 ATOM 2004 C C . MET A 1 245 ? 13.142 9.990 -27.827 1.00 16.33 ? 262 MET A C 1 ATOM 2005 O O . MET A 1 245 ? 12.255 10.844 -27.756 1.00 16.68 ? 262 MET A O 1 ATOM 2006 C CB . MET A 1 245 ? 12.751 8.336 -29.722 1.00 16.43 ? 262 MET A CB 1 ATOM 2007 C CG . MET A 1 245 ? 11.262 8.621 -29.850 1.00 16.51 ? 262 MET A CG 1 ATOM 2008 S SD . MET A 1 245 ? 10.932 9.961 -31.006 1.00 17.35 ? 262 MET A SD 1 ATOM 2009 C CE . MET A 1 245 ? 10.979 9.085 -32.567 1.00 17.77 ? 262 MET A CE 1 ATOM 2010 N N . TRP A 1 246 ? 13.751 9.481 -26.755 1.00 15.93 ? 263 TRP A N 1 ATOM 2011 C CA . TRP A 1 246 ? 13.362 9.794 -25.369 1.00 15.78 ? 263 TRP A CA 1 ATOM 2012 C C . TRP A 1 246 ? 14.429 10.622 -24.657 1.00 16.58 ? 263 TRP A C 1 ATOM 2013 O O . TRP A 1 246 ? 14.294 10.909 -23.466 1.00 16.10 ? 263 TRP A O 1 ATOM 2014 C CB . TRP A 1 246 ? 13.056 8.479 -24.608 1.00 16.10 ? 263 TRP A CB 1 ATOM 2015 C CG . TRP A 1 246 ? 12.171 7.629 -25.432 1.00 16.18 ? 263 TRP A CG 1 ATOM 2016 C CD1 . TRP A 1 246 ? 10.824 7.742 -25.552 1.00 16.26 ? 263 TRP A CD1 1 ATOM 2017 C CD2 . TRP A 1 246 ? 12.576 6.624 -26.363 1.00 16.20 ? 263 TRP A CD2 1 ATOM 2018 N NE1 . TRP A 1 246 ? 10.350 6.845 -26.487 1.00 16.43 ? 263 TRP A NE1 1 ATOM 2019 C CE2 . TRP A 1 246 ? 11.410 6.152 -27.004 1.00 16.31 ? 263 TRP A CE2 1 ATOM 2020 C CE3 . TRP A 1 246 ? 13.815 6.071 -26.719 1.00 16.76 ? 263 TRP A CE3 1 ATOM 2021 C CZ2 . TRP A 1 246 ? 11.443 5.140 -27.971 1.00 16.36 ? 263 TRP A CZ2 1 ATOM 2022 C CZ3 . TRP A 1 246 ? 13.851 5.076 -27.683 1.00 16.61 ? 263 TRP A CZ3 1 ATOM 2023 C CH2 . TRP A 1 246 ? 12.667 4.617 -28.297 1.00 16.53 ? 263 TRP A CH2 1 ATOM 2024 N N . ALA A 1 247 ? 15.459 11.040 -25.404 1.00 16.18 ? 264 ALA A N 1 ATOM 2025 C CA . ALA A 1 247 ? 16.641 11.704 -24.865 1.00 16.89 ? 264 ALA A CA 1 ATOM 2026 C C . ALA A 1 247 ? 17.256 10.985 -23.672 1.00 16.64 ? 264 ALA A C 1 ATOM 2027 O O . ALA A 1 247 ? 17.797 11.617 -22.797 1.00 16.24 ? 264 ALA A O 1 ATOM 2028 C CB . ALA A 1 247 ? 16.322 13.155 -24.513 1.00 17.23 ? 264 ALA A CB 1 ATOM 2029 N N . GLN A 1 248 ? 17.189 9.660 -23.652 1.00 16.97 ? 265 GLN A N 1 ATOM 2030 C CA . GLN A 1 248 ? 17.658 8.905 -22.486 1.00 17.92 ? 265 GLN A CA 1 ATOM 2031 C C . GLN A 1 248 ? 19.172 8.679 -22.500 1.00 18.30 ? 265 GLN A C 1 ATOM 2032 O O . GLN A 1 248 ? 19.774 8.464 -21.457 1.00 17.84 ? 265 GLN A O 1 ATOM 2033 C CB . GLN A 1 248 ? 16.933 7.576 -22.373 1.00 17.85 ? 265 GLN A CB 1 ATOM 2034 C CG . GLN A 1 248 ? 17.279 6.561 -23.445 1.00 17.91 ? 265 GLN A CG 1 ATOM 2035 C CD . GLN A 1 248 ? 16.360 5.371 -23.370 1.00 19.28 ? 265 GLN A CD 1 ATOM 2036 O OE1 . GLN A 1 248 ? 15.164 5.492 -23.601 1.00 17.93 ? 265 GLN A OE1 1 ATOM 2037 N NE2 . GLN A 1 248 ? 16.913 4.217 -23.007 1.00 20.36 ? 265 GLN A NE2 1 ATOM 2038 N N . GLN A 1 249 ? 19.766 8.697 -23.687 1.00 19.36 ? 266 GLN A N 1 ATOM 2039 C CA . GLN A 1 249 ? 21.216 8.755 -23.834 1.00 20.81 ? 266 GLN A CA 1 ATOM 2040 C C . GLN A 1 249 ? 21.517 9.551 -25.091 1.00 19.78 ? 266 GLN A C 1 ATOM 2041 O O . GLN A 1 249 ? 20.716 9.550 -26.030 1.00 18.26 ? 266 GLN A O 1 ATOM 2042 C CB . GLN A 1 249 ? 21.828 7.354 -23.897 1.00 23.58 ? 266 GLN A CB 1 ATOM 2043 C CG . GLN A 1 249 ? 21.304 6.469 -25.009 1.00 27.63 ? 266 GLN A CG 1 ATOM 2044 C CD . GLN A 1 249 ? 22.129 6.485 -26.284 1.00 32.74 ? 266 GLN A CD 1 ATOM 2045 O OE1 . GLN A 1 249 ? 23.081 7.261 -26.431 1.00 38.18 ? 266 GLN A OE1 1 ATOM 2046 N NE2 . GLN A 1 249 ? 21.765 5.615 -27.222 1.00 35.52 ? 266 GLN A NE2 1 ATOM 2047 N N . TRP A 1 250 ? 22.655 10.240 -25.091 1.00 19.03 ? 267 TRP A N 1 ATOM 2048 C CA . TRP A 1 250 ? 22.949 11.237 -26.124 1.00 18.83 ? 267 TRP A CA 1 ATOM 2049 C C . TRP A 1 250 ? 24.172 10.901 -26.975 1.00 19.09 ? 267 TRP A C 1 ATOM 2050 O O . TRP A 1 250 ? 24.674 11.764 -27.691 1.00 18.76 ? 267 TRP A O 1 ATOM 2051 C CB . TRP A 1 250 ? 23.147 12.635 -25.502 1.00 18.26 ? 267 TRP A CB 1 ATOM 2052 C CG . TRP A 1 250 ? 22.098 13.106 -24.557 1.00 17.96 ? 267 TRP A CG 1 ATOM 2053 C CD1 . TRP A 1 250 ? 20.818 12.646 -24.433 1.00 18.44 ? 267 TRP A CD1 1 ATOM 2054 C CD2 . TRP A 1 250 ? 22.227 14.180 -23.615 1.00 18.05 ? 267 TRP A CD2 1 ATOM 2055 N NE1 . TRP A 1 250 ? 20.154 13.341 -23.449 1.00 18.50 ? 267 TRP A NE1 1 ATOM 2056 C CE2 . TRP A 1 250 ? 20.995 14.295 -22.938 1.00 18.13 ? 267 TRP A CE2 1 ATOM 2057 C CE3 . TRP A 1 250 ? 23.272 15.054 -23.276 1.00 17.80 ? 267 TRP A CE3 1 ATOM 2058 C CZ2 . TRP A 1 250 ? 20.775 15.245 -21.930 1.00 18.39 ? 267 TRP A CZ2 1 ATOM 2059 C CZ3 . TRP A 1 250 ? 23.061 15.996 -22.279 1.00 18.03 ? 267 TRP A CZ3 1 ATOM 2060 C CH2 . TRP A 1 250 ? 21.816 16.080 -21.611 1.00 18.43 ? 267 TRP A CH2 1 ATOM 2061 N N . SER A 1 251 ? 24.632 9.655 -26.945 1.00 19.97 ? 268 SER A N 1 ATOM 2062 C CA . SER A 1 251 ? 25.874 9.312 -27.637 1.00 20.86 ? 268 SER A CA 1 ATOM 2063 C C . SER A 1 251 ? 25.762 9.399 -29.159 1.00 21.06 ? 268 SER A C 1 ATOM 2064 O O . SER A 1 251 ? 26.780 9.559 -29.819 1.00 20.23 ? 268 SER A O 1 ATOM 2065 C CB . SER A 1 251 ? 26.369 7.931 -27.236 1.00 21.60 ? 268 SER A CB 1 ATOM 2066 O OG . SER A 1 251 ? 25.383 6.967 -27.483 1.00 22.78 ? 268 SER A OG 1 ATOM 2067 N N . GLU A 1 252 ? 24.547 9.330 -29.711 1.00 20.35 ? 269 GLU A N 1 ATOM 2068 C CA . GLU A 1 252 ? 24.368 9.434 -31.166 1.00 21.62 ? 269 GLU A CA 1 ATOM 2069 C C . GLU A 1 252 ? 24.724 10.818 -31.736 1.00 20.94 ? 269 GLU A C 1 ATOM 2070 O O . GLU A 1 252 ? 24.959 10.925 -32.933 1.00 20.94 ? 269 GLU A O 1 ATOM 2071 C CB . GLU A 1 252 ? 22.946 9.037 -31.598 1.00 23.37 ? 269 GLU A CB 1 ATOM 2072 C CG . GLU A 1 252 ? 22.585 7.572 -31.354 1.00 25.65 ? 269 GLU A CG 1 ATOM 2073 C CD . GLU A 1 252 ? 23.293 6.592 -32.286 1.00 28.00 ? 269 GLU A CD 1 ATOM 2074 O OE1 . GLU A 1 252 ? 23.948 7.012 -33.269 1.00 30.54 ? 269 GLU A OE1 1 ATOM 2075 O OE2 . GLU A 1 252 ? 23.176 5.378 -32.041 1.00 31.92 ? 269 GLU A OE2 1 ATOM 2076 N N . ILE A 1 253 ? 24.781 11.858 -30.895 1.00 20.43 ? 270 ILE A N 1 ATOM 2077 C CA . ILE A 1 253 ? 25.228 13.191 -31.334 1.00 20.35 ? 270 ILE A CA 1 ATOM 2078 C C . ILE A 1 253 ? 26.672 13.518 -30.947 1.00 21.70 ? 270 ILE A C 1 ATOM 2079 O O . ILE A 1 253 ? 27.086 14.678 -31.003 1.00 21.18 ? 270 ILE A O 1 ATOM 2080 C CB . ILE A 1 253 ? 24.259 14.306 -30.862 1.00 19.97 ? 270 ILE A CB 1 ATOM 2081 C CG1 . ILE A 1 253 ? 24.160 14.386 -29.332 1.00 19.66 ? 270 ILE A CG1 1 ATOM 2082 C CG2 . ILE A 1 253 ? 22.892 14.083 -31.487 1.00 19.81 ? 270 ILE A CG2 1 ATOM 2083 C CD1 . ILE A 1 253 ? 23.746 15.749 -28.831 1.00 20.24 ? 270 ILE A CD1 1 ATOM 2084 N N . ALA A 1 254 ? 27.447 12.495 -30.586 1.00 24.34 ? 271 ALA A N 1 ATOM 2085 C CA . ALA A 1 254 ? 28.829 12.673 -30.161 1.00 27.45 ? 271 ALA A CA 1 ATOM 2086 C C . ALA A 1 254 ? 29.657 13.433 -31.202 1.00 29.54 ? 271 ALA A C 1 ATOM 2087 O O . ALA A 1 254 ? 30.516 14.227 -30.836 1.00 29.77 ? 271 ALA A O 1 ATOM 2088 C CB . ALA A 1 254 ? 29.468 11.326 -29.844 1.00 28.01 ? 271 ALA A CB 1 ATOM 2089 N N . ASP A 1 255 ? 29.361 13.232 -32.486 1.00 32.02 ? 272 ASP A N 1 ATOM 2090 C CA . ASP A 1 255 ? 30.063 13.958 -33.550 1.00 34.94 ? 272 ASP A CA 1 ATOM 2091 C C . ASP A 1 255 ? 29.753 15.456 -33.660 1.00 34.52 ? 272 ASP A C 1 ATOM 2092 O O . ASP A 1 255 ? 30.436 16.159 -34.396 1.00 36.86 ? 272 ASP A O 1 ATOM 2093 C CB . ASP A 1 255 ? 29.886 13.270 -34.914 1.00 38.08 ? 272 ASP A CB 1 ATOM 2094 C CG . ASP A 1 255 ? 28.443 13.224 -35.395 1.00 39.56 ? 272 ASP A CG 1 ATOM 2095 O OD1 . ASP A 1 255 ? 27.500 13.651 -34.679 1.00 39.91 ? 272 ASP A OD1 1 ATOM 2096 O OD2 . ASP A 1 255 ? 28.260 12.713 -36.518 1.00 44.89 ? 272 ASP A OD2 1 ATOM 2097 N N . ILE A 1 256 ? 28.740 15.958 -32.958 1.00 31.82 ? 273 ILE A N 1 ATOM 2098 C CA . ILE A 1 256 ? 28.551 17.414 -32.877 1.00 31.19 ? 273 ILE A CA 1 ATOM 2099 C C . ILE A 1 256 ? 28.925 18.025 -31.511 1.00 28.42 ? 273 ILE A C 1 ATOM 2100 O O . ILE A 1 256 ? 29.126 19.240 -31.414 1.00 27.19 ? 273 ILE A O 1 ATOM 2101 C CB . ILE A 1 256 ? 27.169 17.860 -33.424 1.00 34.05 ? 273 ILE A CB 1 ATOM 2102 C CG1 . ILE A 1 256 ? 26.003 17.344 -32.596 1.00 35.07 ? 273 ILE A CG1 1 ATOM 2103 C CG2 . ILE A 1 256 ? 27.008 17.386 -34.872 1.00 34.67 ? 273 ILE A CG2 1 ATOM 2104 C CD1 . ILE A 1 256 ? 24.656 17.818 -33.117 1.00 36.02 ? 273 ILE A CD1 1 ATOM 2105 N N . VAL A 1 257 ? 29.092 17.189 -30.485 1.00 25.47 ? 274 VAL A N 1 ATOM 2106 C CA . VAL A 1 257 ? 29.426 17.677 -29.143 1.00 24.95 ? 274 VAL A CA 1 ATOM 2107 C C . VAL A 1 257 ? 30.733 17.139 -28.553 1.00 25.59 ? 274 VAL A C 1 ATOM 2108 O O . VAL A 1 257 ? 30.990 17.372 -27.381 1.00 26.24 ? 274 VAL A O 1 ATOM 2109 C CB . VAL A 1 257 ? 28.257 17.430 -28.147 1.00 24.24 ? 274 VAL A CB 1 ATOM 2110 C CG1 . VAL A 1 257 ? 26.989 18.083 -28.668 1.00 23.69 ? 274 VAL A CG1 1 ATOM 2111 C CG2 . VAL A 1 257 ? 28.018 15.941 -27.897 1.00 24.72 ? 274 VAL A CG2 1 ATOM 2112 N N . SER A 1 258 ? 31.561 16.437 -29.329 1.00 27.44 ? 275 SER A N 1 ATOM 2113 C CA . SER A 1 258 ? 32.775 15.847 -28.750 1.00 28.63 ? 275 SER A CA 1 ATOM 2114 C C . SER A 1 258 ? 33.758 16.951 -28.348 1.00 27.47 ? 275 SER A C 1 ATOM 2115 O O . SER A 1 258 ? 33.970 17.891 -29.116 1.00 26.98 ? 275 SER A O 1 ATOM 2116 C CB . SER A 1 258 ? 33.463 14.870 -29.697 1.00 30.80 ? 275 SER A CB 1 ATOM 2117 O OG . SER A 1 258 ? 33.991 15.555 -30.810 1.00 36.65 ? 275 SER A OG 1 ATOM 2118 N N . PRO A 1 259 ? 34.333 16.856 -27.137 1.00 26.95 ? 276 PRO A N 1 ATOM 2119 C CA . PRO A 1 259 ? 35.325 17.816 -26.643 1.00 27.16 ? 276 PRO A CA 1 ATOM 2120 C C . PRO A 1 259 ? 36.413 18.199 -27.642 1.00 26.18 ? 276 PRO A C 1 ATOM 2121 O O . PRO A 1 259 ? 36.702 19.379 -27.791 1.00 25.79 ? 276 PRO A O 1 ATOM 2122 C CB . PRO A 1 259 ? 35.936 17.080 -25.459 1.00 26.60 ? 276 PRO A CB 1 ATOM 2123 C CG . PRO A 1 259 ? 34.779 16.328 -24.894 1.00 27.70 ? 276 PRO A CG 1 ATOM 2124 C CD . PRO A 1 259 ? 33.933 15.922 -26.068 1.00 27.49 ? 276 PRO A CD 1 ATOM 2125 N N . PHE A 1 260 ? 36.977 17.211 -28.326 1.00 25.68 ? 277 PHE A N 1 ATOM 2126 C CA . PHE A 1 260 ? 38.091 17.428 -29.254 1.00 26.31 ? 277 PHE A CA 1 ATOM 2127 C C . PHE A 1 260 ? 37.787 16.838 -30.610 1.00 25.94 ? 277 PHE A C 1 ATOM 2128 O O . PHE A 1 260 ? 38.171 15.702 -30.887 1.00 26.48 ? 277 PHE A O 1 ATOM 2129 C CB . PHE A 1 260 ? 39.375 16.839 -28.673 1.00 26.37 ? 277 PHE A CB 1 ATOM 2130 C CG . PHE A 1 260 ? 39.781 17.487 -27.397 1.00 27.17 ? 277 PHE A CG 1 ATOM 2131 C CD1 . PHE A 1 260 ? 40.337 18.763 -27.408 1.00 27.38 ? 277 PHE A CD1 1 ATOM 2132 C CD2 . PHE A 1 260 ? 39.569 16.853 -26.174 1.00 27.77 ? 277 PHE A CD2 1 ATOM 2133 C CE1 . PHE A 1 260 ? 40.699 19.388 -26.227 1.00 27.97 ? 277 PHE A CE1 1 ATOM 2134 C CE2 . PHE A 1 260 ? 39.925 17.476 -24.991 1.00 28.02 ? 277 PHE A CE2 1 ATOM 2135 C CZ . PHE A 1 260 ? 40.494 18.746 -25.019 1.00 28.90 ? 277 PHE A CZ 1 ATOM 2136 N N . PRO A 1 261 ? 37.110 17.614 -31.481 1.00 27.78 ? 278 PRO A N 1 ATOM 2137 C CA . PRO A 1 261 ? 36.702 17.084 -32.793 1.00 29.40 ? 278 PRO A CA 1 ATOM 2138 C C . PRO A 1 261 ? 37.839 16.725 -33.775 1.00 31.52 ? 278 PRO A C 1 ATOM 2139 O O . PRO A 1 261 ? 37.609 15.960 -34.708 1.00 32.51 ? 278 PRO A O 1 ATOM 2140 C CB . PRO A 1 261 ? 35.777 18.173 -33.358 1.00 29.64 ? 278 PRO A CB 1 ATOM 2141 C CG . PRO A 1 261 ? 36.041 19.394 -32.555 1.00 28.98 ? 278 PRO A CG 1 ATOM 2142 C CD . PRO A 1 261 ? 36.624 18.988 -31.248 1.00 27.75 ? 278 PRO A CD 1 ATOM 2143 N N . GLU A 1 262 ? 39.040 17.261 -33.558 1.00 32.41 ? 279 GLU A N 1 ATOM 2144 C CA . GLU A 1 262 ? 40.229 16.859 -34.322 1.00 35.33 ? 279 GLU A CA 1 ATOM 2145 C C . GLU A 1 262 ? 40.800 15.509 -33.882 1.00 38.01 ? 279 GLU A C 1 ATOM 2146 O O . GLU A 1 262 ? 41.576 14.912 -34.621 1.00 38.58 ? 279 GLU A O 1 ATOM 2147 C CB . GLU A 1 262 ? 41.342 17.917 -34.202 1.00 35.83 ? 279 GLU A CB 1 ATOM 2148 C CG . GLU A 1 262 ? 40.972 19.317 -34.698 1.00 35.98 ? 279 GLU A CG 1 ATOM 2149 C CD . GLU A 1 262 ? 40.659 19.380 -36.191 1.00 36.53 ? 279 GLU A CD 1 ATOM 2150 O OE1 . GLU A 1 262 ? 41.304 18.650 -36.978 1.00 36.35 ? 279 GLU A OE1 1 ATOM 2151 O OE2 . GLU A 1 262 ? 39.769 20.169 -36.582 1.00 35.05 ? 279 GLU A OE2 1 ATOM 2152 N N . LYS A 1 263 ? 40.429 15.044 -32.685 1.00 39.01 ? 280 LYS A N 1 ATOM 2153 C CA . LYS A 1 263 ? 40.981 13.821 -32.079 1.00 39.04 ? 280 LYS A CA 1 ATOM 2154 C C . LYS A 1 263 ? 39.978 12.682 -32.173 1.00 39.57 ? 280 LYS A C 1 ATOM 2155 O O . LYS A 1 263 ? 38.789 12.939 -32.376 1.00 40.26 ? 280 LYS A O 1 ATOM 2156 C CB . LYS A 1 263 ? 41.354 14.091 -30.617 1.00 39.98 ? 280 LYS A CB 1 ATOM 2157 C CG . LYS A 1 263 ? 42.634 14.895 -30.441 1.00 40.95 ? 280 LYS A CG 1 ATOM 2158 C CD . LYS A 1 263 ? 43.886 14.080 -30.765 1.00 41.91 ? 280 LYS A CD 1 ATOM 2159 C CE . LYS A 1 263 ? 45.131 14.955 -30.853 1.00 41.94 ? 280 LYS A CE 1 ATOM 2160 N NZ . LYS A 1 263 ? 45.678 15.292 -29.513 1.00 42.37 ? 280 LYS A NZ 1 ATOM 2161 N N . PRO A 1 264 ? 40.450 11.421 -32.020 1.00 38.82 ? 281 PRO A N 1 ATOM 2162 C CA . PRO A 1 264 ? 39.568 10.296 -32.317 1.00 38.71 ? 281 PRO A CA 1 ATOM 2163 C C . PRO A 1 264 ? 38.370 10.175 -31.372 1.00 38.66 ? 281 PRO A C 1 ATOM 2164 O O . PRO A 1 264 ? 38.486 10.454 -30.161 1.00 34.23 ? 281 PRO A O 1 ATOM 2165 C CB . PRO A 1 264 ? 40.488 9.071 -32.195 1.00 38.72 ? 281 PRO A CB 1 ATOM 2166 C CG . PRO A 1 264 ? 41.588 9.510 -31.307 1.00 39.16 ? 281 PRO A CG 1 ATOM 2167 C CD . PRO A 1 264 ? 41.798 10.958 -31.642 1.00 39.44 ? 281 PRO A CD 1 ATOM 2168 N N . LEU A 1 265 ? 37.242 9.794 -31.969 1.00 38.15 ? 282 LEU A N 1 ATOM 2169 C CA . LEU A 1 265 ? 36.002 9.459 -31.278 1.00 38.72 ? 282 LEU A CA 1 ATOM 2170 C C . LEU A 1 265 ? 35.653 8.028 -31.684 1.00 37.33 ? 282 LEU A C 1 ATOM 2171 O O . LEU A 1 265 ? 35.427 7.751 -32.868 1.00 35.87 ? 282 LEU A O 1 ATOM 2172 C CB . LEU A 1 265 ? 34.899 10.416 -31.719 1.00 41.01 ? 282 LEU A CB 1 ATOM 2173 C CG . LEU A 1 265 ? 33.505 10.253 -31.112 1.00 42.57 ? 282 LEU A CG 1 ATOM 2174 C CD1 . LEU A 1 265 ? 33.522 10.575 -29.623 1.00 43.79 ? 282 LEU A CD1 1 ATOM 2175 C CD2 . LEU A 1 265 ? 32.509 11.137 -31.853 1.00 43.25 ? 282 LEU A CD2 1 ATOM 2176 N N . VAL A 1 266 ? 35.626 7.120 -30.712 1.00 35.28 ? 283 VAL A N 1 ATOM 2177 C CA . VAL A 1 266 ? 35.438 5.704 -31.003 1.00 32.98 ? 283 VAL A CA 1 ATOM 2178 C C . VAL A 1 266 ? 34.004 5.459 -31.509 1.00 31.92 ? 283 VAL A C 1 ATOM 2179 O O . VAL A 1 266 ? 33.025 5.718 -30.793 1.00 29.46 ? 283 VAL A O 1 ATOM 2180 C CB . VAL A 1 266 ? 35.750 4.825 -29.770 1.00 33.75 ? 283 VAL A CB 1 ATOM 2181 C CG1 . VAL A 1 266 ? 35.415 3.362 -30.036 1.00 34.30 ? 283 VAL A CG1 1 ATOM 2182 C CG2 . VAL A 1 266 ? 37.218 4.973 -29.369 1.00 34.26 ? 283 VAL A CG2 1 ATOM 2183 N N . ASP A 1 267 ? 33.907 5.011 -32.760 1.00 28.81 ? 284 ASP A N 1 ATOM 2184 C CA . ASP A 1 267 ? 32.670 4.463 -33.316 1.00 29.36 ? 284 ASP A CA 1 ATOM 2185 C C . ASP A 1 267 ? 33.046 3.321 -34.256 1.00 27.15 ? 284 ASP A C 1 ATOM 2186 O O . ASP A 1 267 ? 33.432 3.547 -35.407 1.00 26.95 ? 284 ASP A O 1 ATOM 2187 C CB . ASP A 1 267 ? 31.859 5.536 -34.053 1.00 31.07 ? 284 ASP A CB 1 ATOM 2188 C CG . ASP A 1 267 ? 30.515 5.017 -34.559 1.00 32.54 ? 284 ASP A CG 1 ATOM 2189 O OD1 . ASP A 1 267 ? 30.289 3.782 -34.602 1.00 32.26 ? 284 ASP A OD1 1 ATOM 2190 O OD2 . ASP A 1 267 ? 29.671 5.865 -34.913 1.00 35.43 ? 284 ASP A OD2 1 ATOM 2191 N N . VAL A 1 268 ? 32.918 2.099 -33.753 1.00 24.73 ? 285 VAL A N 1 ATOM 2192 C CA . VAL A 1 268 ? 33.403 0.912 -34.457 1.00 24.49 ? 285 VAL A CA 1 ATOM 2193 C C . VAL A 1 268 ? 32.398 0.306 -35.449 1.00 23.50 ? 285 VAL A C 1 ATOM 2194 O O . VAL A 1 268 ? 32.722 -0.694 -36.084 1.00 22.99 ? 285 VAL A O 1 ATOM 2195 C CB . VAL A 1 268 ? 33.925 -0.168 -33.474 1.00 24.56 ? 285 VAL A CB 1 ATOM 2196 C CG1 . VAL A 1 268 ? 34.972 0.437 -32.543 1.00 25.43 ? 285 VAL A CG1 1 ATOM 2197 C CG2 . VAL A 1 268 ? 32.793 -0.837 -32.686 1.00 24.34 ? 285 VAL A CG2 1 ATOM 2198 N N . SER A 1 269 ? 31.206 0.906 -35.595 1.00 23.11 ? 286 SER A N 1 ATOM 2199 C CA . SER A 1 269 ? 30.174 0.410 -36.525 1.00 22.95 ? 286 SER A CA 1 ATOM 2200 C C . SER A 1 269 ? 30.717 0.171 -37.945 1.00 23.44 ? 286 SER A C 1 ATOM 2201 O O . SER A 1 269 ? 30.487 -0.888 -38.537 1.00 23.38 ? 286 SER A O 1 ATOM 2202 C CB . SER A 1 269 ? 28.981 1.381 -36.597 1.00 23.53 ? 286 SER A CB 1 ATOM 2203 O OG . SER A 1 269 ? 28.423 1.627 -35.307 1.00 23.17 ? 286 SER A OG 1 ATOM 2204 N N . ALA A 1 270 ? 31.455 1.139 -38.479 1.00 23.52 ? 287 ALA A N 1 ATOM 2205 C CA . ALA A 1 270 ? 32.022 1.003 -39.837 1.00 23.73 ? 287 ALA A CA 1 ATOM 2206 C C . ALA A 1 270 ? 32.983 -0.173 -39.965 1.00 23.44 ? 287 ALA A C 1 ATOM 2207 O O . ALA A 1 270 ? 32.910 -0.931 -40.937 1.00 23.53 ? 287 ALA A O 1 ATOM 2208 C CB . ALA A 1 270 ? 32.709 2.293 -40.267 1.00 24.30 ? 287 ALA A CB 1 ATOM 2209 N N . GLU A 1 271 ? 33.888 -0.328 -38.995 1.00 24.42 ? 288 GLU A N 1 ATOM 2210 C CA . GLU A 1 271 ? 34.820 -1.471 -39.007 1.00 24.75 ? 288 GLU A CA 1 ATOM 2211 C C . GLU A 1 271 ? 34.106 -2.813 -38.873 1.00 24.49 ? 288 GLU A C 1 ATOM 2212 O O . GLU A 1 271 ? 34.495 -3.779 -39.522 1.00 23.48 ? 288 GLU A O 1 ATOM 2213 C CB . GLU A 1 271 ? 35.897 -1.337 -37.920 1.00 26.67 ? 288 GLU A CB 1 ATOM 2214 C CG . GLU A 1 271 ? 37.077 -0.466 -38.325 1.00 28.16 ? 288 GLU A CG 1 ATOM 2215 C CD . GLU A 1 271 ? 37.852 -1.005 -39.531 1.00 30.04 ? 288 GLU A CD 1 ATOM 2216 O OE1 . GLU A 1 271 ? 37.850 -2.232 -39.781 1.00 30.50 ? 288 GLU A OE1 1 ATOM 2217 O OE2 . GLU A 1 271 ? 38.460 -0.181 -40.240 1.00 33.59 ? 288 GLU A OE2 1 ATOM 2218 N N . MET A 1 272 ? 33.073 -2.879 -38.027 1.00 23.76 ? 289 MET A N 1 ATOM 2219 C CA . MET A 1 272 ? 32.228 -4.079 -37.937 1.00 23.64 ? 289 MET A CA 1 ATOM 2220 C C . MET A 1 272 ? 31.669 -4.444 -39.323 1.00 23.86 ? 289 MET A C 1 ATOM 2221 O O . MET A 1 272 ? 31.752 -5.596 -39.749 1.00 23.19 ? 289 MET A O 1 ATOM 2222 C CB . MET A 1 272 ? 31.065 -3.871 -36.942 1.00 24.51 ? 289 MET A CB 1 ATOM 2223 C CG . MET A 1 272 ? 31.463 -3.755 -35.466 1.00 24.93 ? 289 MET A CG 1 ATOM 2224 S SD . MET A 1 272 ? 30.101 -3.177 -34.400 1.00 25.61 ? 289 MET A SD 1 ATOM 2225 C CE . MET A 1 272 ? 29.093 -4.648 -34.351 1.00 25.60 ? 289 MET A CE 1 ATOM 2226 N N . GLU A 1 273 ? 31.121 -3.454 -40.029 1.00 23.70 ? 290 GLU A N 1 ATOM 2227 C CA . GLU A 1 273 ? 30.581 -3.680 -41.381 1.00 24.59 ? 290 GLU A CA 1 ATOM 2228 C C . GLU A 1 273 ? 31.666 -4.051 -42.394 1.00 25.14 ? 290 GLU A C 1 ATOM 2229 O O . GLU A 1 273 ? 31.486 -4.983 -43.178 1.00 24.82 ? 290 GLU A O 1 ATOM 2230 C CB . GLU A 1 273 ? 29.826 -2.450 -41.870 1.00 25.54 ? 290 GLU A CB 1 ATOM 2231 C CG . GLU A 1 273 ? 28.575 -2.177 -41.059 1.00 26.76 ? 290 GLU A CG 1 ATOM 2232 C CD . GLU A 1 273 ? 27.643 -1.205 -41.730 1.00 29.88 ? 290 GLU A CD 1 ATOM 2233 O OE1 . GLU A 1 273 ? 28.132 -0.265 -42.381 1.00 31.46 ? 290 GLU A OE1 1 ATOM 2234 O OE2 . GLU A 1 273 ? 26.414 -1.409 -41.628 1.00 33.99 ? 290 GLU A OE2 1 ATOM 2235 N N . LYS A 1 274 ? 32.788 -3.333 -42.358 1.00 26.36 ? 291 LYS A N 1 ATOM 2236 C CA . LYS A 1 274 ? 33.941 -3.629 -43.234 1.00 28.29 ? 291 LYS A CA 1 ATOM 2237 C C . LYS A 1 274 ? 34.430 -5.065 -43.079 1.00 29.03 ? 291 LYS A C 1 ATOM 2238 O O . LYS A 1 274 ? 34.843 -5.691 -44.052 1.00 29.51 ? 291 LYS A O 1 ATOM 2239 C CB . LYS A 1 274 ? 35.104 -2.680 -42.946 1.00 29.82 ? 291 LYS A CB 1 ATOM 2240 C CG . LYS A 1 274 ? 34.949 -1.279 -43.500 1.00 31.79 ? 291 LYS A CG 1 ATOM 2241 C CD . LYS A 1 274 ? 36.117 -0.418 -43.038 1.00 34.05 ? 291 LYS A CD 1 ATOM 2242 C CE . LYS A 1 274 ? 36.271 0.856 -43.845 1.00 36.89 ? 291 LYS A CE 1 ATOM 2243 N NZ . LYS A 1 274 ? 35.329 1.913 -43.391 1.00 39.41 ? 291 LYS A NZ 1 ATOM 2244 N N . GLN A 1 275 ? 34.376 -5.582 -41.854 1.00 28.16 ? 292 GLN A N 1 ATOM 2245 C CA . GLN A 1 275 ? 34.823 -6.947 -41.565 1.00 28.83 ? 292 GLN A CA 1 ATOM 2246 C C . GLN A 1 275 ? 33.727 -8.012 -41.706 1.00 28.53 ? 292 GLN A C 1 ATOM 2247 O O . GLN A 1 275 ? 33.952 -9.177 -41.375 1.00 31.06 ? 292 GLN A O 1 ATOM 2248 C CB . GLN A 1 275 ? 35.471 -6.989 -40.182 1.00 28.98 ? 292 GLN A CB 1 ATOM 2249 C CG . GLN A 1 275 ? 36.707 -6.097 -40.086 1.00 29.12 ? 292 GLN A CG 1 ATOM 2250 C CD . GLN A 1 275 ? 37.324 -6.093 -38.705 1.00 28.42 ? 292 GLN A CD 1 ATOM 2251 O OE1 . GLN A 1 275 ? 37.312 -7.101 -38.024 1.00 30.35 ? 292 GLN A OE1 1 ATOM 2252 N NE2 . GLN A 1 275 ? 37.862 -4.960 -38.292 1.00 29.67 ? 292 GLN A NE2 1 ATOM 2253 N N . GLY A 1 276 ? 32.565 -7.633 -42.240 1.00 26.75 ? 293 GLY A N 1 ATOM 2254 C CA . GLY A 1 276 ? 31.495 -8.574 -42.508 1.00 26.40 ? 293 GLY A CA 1 ATOM 2255 C C . GLY A 1 276 ? 30.818 -9.127 -41.265 1.00 26.69 ? 293 GLY A C 1 ATOM 2256 O O . GLY A 1 276 ? 30.298 -10.235 -41.287 1.00 26.29 ? 293 GLY A O 1 ATOM 2257 N N . TYR A 1 277 ? 30.807 -8.352 -40.185 1.00 26.53 ? 294 TYR A N 1 ATOM 2258 C CA . TYR A 1 277 ? 30.036 -8.721 -38.995 1.00 26.70 ? 294 TYR A CA 1 ATOM 2259 C C . TYR A 1 277 ? 28.571 -8.925 -39.340 1.00 25.90 ? 294 TYR A C 1 ATOM 2260 O O . TYR A 1 277 ? 28.012 -8.246 -40.206 1.00 25.33 ? 294 TYR A O 1 ATOM 2261 C CB . TYR A 1 277 ? 30.127 -7.656 -37.910 1.00 27.15 ? 294 TYR A CB 1 ATOM 2262 C CG . TYR A 1 277 ? 31.324 -7.776 -37.001 1.00 29.13 ? 294 TYR A CG 1 ATOM 2263 C CD1 . TYR A 1 277 ? 32.621 -7.950 -37.506 1.00 29.97 ? 294 TYR A CD1 1 ATOM 2264 C CD2 . TYR A 1 277 ? 31.162 -7.691 -35.627 1.00 29.94 ? 294 TYR A CD2 1 ATOM 2265 C CE1 . TYR A 1 277 ? 33.713 -8.042 -36.657 1.00 31.17 ? 294 TYR A CE1 1 ATOM 2266 C CE2 . TYR A 1 277 ? 32.242 -7.781 -34.781 1.00 32.01 ? 294 TYR A CE2 1 ATOM 2267 C CZ . TYR A 1 277 ? 33.511 -7.962 -35.289 1.00 32.07 ? 294 TYR A CZ 1 ATOM 2268 O OH . TYR A 1 277 ? 34.561 -8.059 -34.408 1.00 34.94 ? 294 TYR A OH 1 ATOM 2269 N N . THR A 1 278 ? 27.974 -9.886 -38.654 1.00 24.66 ? 295 THR A N 1 ATOM 2270 C CA . THR A 1 278 ? 26.567 -10.192 -38.756 1.00 24.29 ? 295 THR A CA 1 ATOM 2271 C C . THR A 1 278 ? 26.026 -10.237 -37.335 1.00 23.23 ? 295 THR A C 1 ATOM 2272 O O . THR A 1 278 ? 26.806 -10.289 -36.386 1.00 21.52 ? 295 THR A O 1 ATOM 2273 C CB . THR A 1 278 ? 26.362 -11.577 -39.370 1.00 24.46 ? 295 THR A CB 1 ATOM 2274 O OG1 . THR A 1 278 ? 27.008 -12.557 -38.544 1.00 23.30 ? 295 THR A OG1 1 ATOM 2275 C CG2 . THR A 1 278 ? 26.927 -11.628 -40.790 1.00 25.55 ? 295 THR A CG2 1 ATOM 2276 N N . PRO A 1 279 ? 24.697 -10.239 -37.184 1.00 23.16 ? 296 PRO A N 1 ATOM 2277 C CA . PRO A 1 279 ? 24.129 -10.486 -35.855 1.00 22.77 ? 296 PRO A CA 1 ATOM 2278 C C . PRO A 1 279 ? 24.667 -11.780 -35.214 1.00 22.58 ? 296 PRO A C 1 ATOM 2279 O O . PRO A 1 279 ? 25.033 -11.779 -34.037 1.00 21.15 ? 296 PRO A O 1 ATOM 2280 C CB . PRO A 1 279 ? 22.629 -10.571 -36.145 1.00 23.58 ? 296 PRO A CB 1 ATOM 2281 C CG . PRO A 1 279 ? 22.439 -9.619 -37.295 1.00 23.11 ? 296 PRO A CG 1 ATOM 2282 C CD . PRO A 1 279 ? 23.655 -9.833 -38.155 1.00 23.92 ? 296 PRO A CD 1 ATOM 2283 N N . LEU A 1 280 ? 24.785 -12.852 -35.993 1.00 22.58 ? 297 LEU A N 1 ATOM 2284 C CA . LEU A 1 280 ? 25.281 -14.122 -35.456 1.00 23.59 ? 297 LEU A CA 1 ATOM 2285 C C . LEU A 1 280 ? 26.661 -13.956 -34.842 1.00 23.28 ? 297 LEU A C 1 ATOM 2286 O O . LEU A 1 280 ? 26.886 -14.348 -33.700 1.00 22.60 ? 297 LEU A O 1 ATOM 2287 C CB . LEU A 1 280 ? 25.308 -15.210 -36.537 1.00 24.71 ? 297 LEU A CB 1 ATOM 2288 C CG . LEU A 1 280 ? 25.779 -16.597 -36.079 1.00 25.91 ? 297 LEU A CG 1 ATOM 2289 C CD1 . LEU A 1 280 ? 24.874 -17.148 -34.984 1.00 25.87 ? 297 LEU A CD1 1 ATOM 2290 C CD2 . LEU A 1 280 ? 25.849 -17.538 -37.272 1.00 26.66 ? 297 LEU A CD2 1 ATOM 2291 N N . LYS A 1 281 ? 27.565 -13.351 -35.603 1.00 23.95 ? 298 LYS A N 1 ATOM 2292 C CA . LYS A 1 281 ? 28.922 -13.046 -35.143 1.00 25.58 ? 298 LYS A CA 1 ATOM 2293 C C . LYS A 1 281 ? 28.937 -12.194 -33.876 1.00 24.00 ? 298 LYS A C 1 ATOM 2294 O O . LYS A 1 281 ? 29.753 -12.425 -32.987 1.00 23.49 ? 298 LYS A O 1 ATOM 2295 C CB . LYS A 1 281 ? 29.685 -12.327 -36.256 1.00 28.75 ? 298 LYS A CB 1 ATOM 2296 C CG . LYS A 1 281 ? 31.101 -11.845 -35.930 1.00 32.75 ? 298 LYS A CG 1 ATOM 2297 C CD . LYS A 1 281 ? 32.177 -12.832 -36.353 1.00 36.32 ? 298 LYS A CD 1 ATOM 2298 C CE . LYS A 1 281 ? 33.550 -12.169 -36.382 1.00 37.79 ? 298 LYS A CE 1 ATOM 2299 N NZ . LYS A 1 281 ? 34.100 -12.012 -35.011 1.00 39.91 ? 298 LYS A NZ 1 ATOM 2300 N N . MET A 1 282 ? 28.046 -11.207 -33.804 1.00 22.91 ? 299 MET A N 1 ATOM 2301 C CA . MET A 1 282 ? 27.952 -10.347 -32.624 1.00 21.96 ? 299 MET A CA 1 ATOM 2302 C C . MET A 1 282 ? 27.589 -11.161 -31.362 1.00 21.34 ? 299 MET A C 1 ATOM 2303 O O . MET A 1 282 ? 28.256 -11.036 -30.326 1.00 20.93 ? 299 MET A O 1 ATOM 2304 C CB . MET A 1 282 ? 26.961 -9.202 -32.869 1.00 22.35 ? 299 MET A CB 1 ATOM 2305 C CG . MET A 1 282 ? 27.429 -8.205 -33.924 1.00 22.20 ? 299 MET A CG 1 ATOM 2306 S SD . MET A 1 282 ? 26.107 -7.117 -34.478 1.00 21.67 ? 299 MET A SD 1 ATOM 2307 C CE . MET A 1 282 ? 25.822 -6.172 -32.982 1.00 21.87 ? 299 MET A CE 1 ATOM 2308 N N . PHE A 1 283 ? 26.568 -12.010 -31.475 1.00 20.67 ? 300 PHE A N 1 ATOM 2309 C CA . PHE A 1 283 ? 26.202 -12.940 -30.392 1.00 21.44 ? 300 PHE A CA 1 ATOM 2310 C C . PHE A 1 283 ? 27.304 -13.956 -30.059 1.00 21.47 ? 300 PHE A C 1 ATOM 2311 O O . PHE A 1 283 ? 27.554 -14.231 -28.886 1.00 20.67 ? 300 PHE A O 1 ATOM 2312 C CB . PHE A 1 283 ? 24.860 -13.631 -30.681 1.00 21.08 ? 300 PHE A CB 1 ATOM 2313 C CG . PHE A 1 283 ? 23.685 -12.744 -30.415 1.00 20.79 ? 300 PHE A CG 1 ATOM 2314 C CD1 . PHE A 1 283 ? 23.203 -11.890 -31.395 1.00 20.53 ? 300 PHE A CD1 1 ATOM 2315 C CD2 . PHE A 1 283 ? 23.098 -12.707 -29.152 1.00 21.79 ? 300 PHE A CD2 1 ATOM 2316 C CE1 . PHE A 1 283 ? 22.138 -11.031 -31.138 1.00 20.85 ? 300 PHE A CE1 1 ATOM 2317 C CE2 . PHE A 1 283 ? 22.030 -11.857 -28.891 1.00 21.60 ? 300 PHE A CE2 1 ATOM 2318 C CZ . PHE A 1 283 ? 21.549 -11.019 -29.884 1.00 21.25 ? 300 PHE A CZ 1 ATOM 2319 N N . GLN A 1 284 ? 27.985 -14.478 -31.077 1.00 21.90 ? 301 GLN A N 1 ATOM 2320 C CA . GLN A 1 284 ? 29.147 -15.357 -30.845 1.00 22.88 ? 301 GLN A CA 1 ATOM 2321 C C . GLN A 1 284 ? 30.259 -14.657 -30.067 1.00 24.57 ? 301 GLN A C 1 ATOM 2322 O O . GLN A 1 284 ? 30.885 -15.258 -29.179 1.00 24.04 ? 301 GLN A O 1 ATOM 2323 C CB . GLN A 1 284 ? 29.694 -15.897 -32.166 1.00 23.68 ? 301 GLN A CB 1 ATOM 2324 C CG . GLN A 1 284 ? 28.771 -16.923 -32.808 1.00 23.91 ? 301 GLN A CG 1 ATOM 2325 C CD . GLN A 1 284 ? 29.136 -17.241 -34.242 1.00 25.49 ? 301 GLN A CD 1 ATOM 2326 O OE1 . GLN A 1 284 ? 29.866 -16.495 -34.894 1.00 27.83 ? 301 GLN A OE1 1 ATOM 2327 N NE2 . GLN A 1 284 ? 28.624 -18.351 -34.744 1.00 25.98 ? 301 GLN A NE2 1 ATOM 2328 N N . MET A 1 285 ? 30.493 -13.383 -30.375 1.00 25.88 ? 302 MET A N 1 ATOM 2329 C CA . MET A 1 285 ? 31.487 -12.608 -29.636 1.00 27.76 ? 302 MET A CA 1 ATOM 2330 C C . MET A 1 285 ? 31.098 -12.380 -28.190 1.00 25.31 ? 302 MET A C 1 ATOM 2331 O O . MET A 1 285 ? 31.958 -12.413 -27.309 1.00 25.00 ? 302 MET A O 1 ATOM 2332 C CB . MET A 1 285 ? 31.729 -11.262 -30.285 1.00 32.87 ? 302 MET A CB 1 ATOM 2333 C CG . MET A 1 285 ? 32.651 -11.338 -31.476 1.00 38.26 ? 302 MET A CG 1 ATOM 2334 S SD . MET A 1 285 ? 32.640 -9.739 -32.283 1.00 49.11 ? 302 MET A SD 1 ATOM 2335 C CE . MET A 1 285 ? 33.117 -8.615 -30.964 1.00 44.60 ? 302 MET A CE 1 ATOM 2336 N N . GLY A 1 286 ? 29.812 -12.130 -27.946 1.00 23.61 ? 303 GLY A N 1 ATOM 2337 C CA . GLY A 1 286 ? 29.313 -11.993 -26.581 1.00 23.03 ? 303 GLY A CA 1 ATOM 2338 C C . GLY A 1 286 ? 29.485 -13.271 -25.783 1.00 22.89 ? 303 GLY A C 1 ATOM 2339 O O . GLY A 1 286 ? 29.972 -13.239 -24.653 1.00 22.48 ? 303 GLY A O 1 ATOM 2340 N N . ASP A 1 287 ? 29.091 -14.390 -26.391 1.00 23.09 ? 304 ASP A N 1 ATOM 2341 C CA . ASP A 1 287 ? 29.282 -15.729 -25.822 1.00 24.12 ? 304 ASP A CA 1 ATOM 2342 C C . ASP A 1 287 ? 30.741 -15.972 -25.445 1.00 24.34 ? 304 ASP A C 1 ATOM 2343 O O . ASP A 1 287 ? 31.037 -16.492 -24.364 1.00 24.77 ? 304 ASP A O 1 ATOM 2344 C CB . ASP A 1 287 ? 28.817 -16.791 -26.834 1.00 24.66 ? 304 ASP A CB 1 ATOM 2345 C CG . ASP A 1 287 ? 28.717 -18.195 -26.245 1.00 25.55 ? 304 ASP A CG 1 ATOM 2346 O OD1 . ASP A 1 287 ? 28.492 -18.380 -25.028 1.00 25.00 ? 304 ASP A OD1 1 ATOM 2347 O OD2 . ASP A 1 287 ? 28.815 -19.143 -27.038 1.00 25.43 ? 304 ASP A OD2 1 ATOM 2348 N N . ASP A 1 288 ? 31.638 -15.576 -26.342 1.00 24.35 ? 305 ASP A N 1 ATOM 2349 C CA . ASP A 1 288 ? 33.078 -15.723 -26.138 1.00 24.59 ? 305 ASP A CA 1 ATOM 2350 C C . ASP A 1 288 ? 33.577 -14.890 -24.957 1.00 23.98 ? 305 ASP A C 1 ATOM 2351 O O . ASP A 1 288 ? 34.468 -15.337 -24.226 1.00 23.42 ? 305 ASP A O 1 ATOM 2352 C CB . ASP A 1 288 ? 33.844 -15.339 -27.406 1.00 25.38 ? 305 ASP A CB 1 ATOM 2353 C CG . ASP A 1 288 ? 35.351 -15.474 -27.243 1.00 26.73 ? 305 ASP A CG 1 ATOM 2354 O OD1 . ASP A 1 288 ? 35.832 -16.620 -27.156 1.00 28.29 ? 305 ASP A OD1 1 ATOM 2355 O OD2 . ASP A 1 288 ? 36.045 -14.441 -27.185 1.00 27.42 ? 305 ASP A OD2 1 ATOM 2356 N N . PHE A 1 289 ? 33.013 -13.693 -24.757 1.00 22.77 ? 306 PHE A N 1 ATOM 2357 C CA . PHE A 1 289 ? 33.401 -12.882 -23.600 1.00 22.75 ? 306 PHE A CA 1 ATOM 2358 C C . PHE A 1 289 ? 33.089 -13.625 -22.289 1.00 22.29 ? 306 PHE A C 1 ATOM 2359 O O . PHE A 1 289 ? 33.951 -13.735 -21.403 1.00 22.82 ? 306 PHE A O 1 ATOM 2360 C CB . PHE A 1 289 ? 32.738 -11.496 -23.622 1.00 22.69 ? 306 PHE A CB 1 ATOM 2361 C CG . PHE A 1 289 ? 33.532 -10.434 -22.911 1.00 22.51 ? 306 PHE A CG 1 ATOM 2362 C CD1 . PHE A 1 289 ? 33.790 -10.532 -21.547 1.00 22.16 ? 306 PHE A CD1 1 ATOM 2363 C CD2 . PHE A 1 289 ? 34.023 -9.326 -23.596 1.00 23.08 ? 306 PHE A CD2 1 ATOM 2364 C CE1 . PHE A 1 289 ? 34.514 -9.557 -20.880 1.00 22.72 ? 306 PHE A CE1 1 ATOM 2365 C CE2 . PHE A 1 289 ? 34.758 -8.350 -22.935 1.00 23.14 ? 306 PHE A CE2 1 ATOM 2366 C CZ . PHE A 1 289 ? 35.012 -8.467 -21.574 1.00 22.92 ? 306 PHE A CZ 1 ATOM 2367 N N . PHE A 1 290 ? 31.874 -14.153 -22.184 1.00 22.56 ? 307 PHE A N 1 ATOM 2368 C CA . PHE A 1 290 ? 31.465 -14.911 -20.994 1.00 22.83 ? 307 PHE A CA 1 ATOM 2369 C C . PHE A 1 290 ? 32.310 -16.173 -20.756 1.00 23.68 ? 307 PHE A C 1 ATOM 2370 O O . PHE A 1 290 ? 32.785 -16.393 -19.632 1.00 24.28 ? 307 PHE A O 1 ATOM 2371 C CB . PHE A 1 290 ? 29.980 -15.254 -21.051 1.00 22.50 ? 307 PHE A CB 1 ATOM 2372 C CG . PHE A 1 290 ? 29.079 -14.078 -20.759 1.00 22.55 ? 307 PHE A CG 1 ATOM 2373 C CD1 . PHE A 1 290 ? 28.867 -13.660 -19.447 1.00 22.21 ? 307 PHE A CD1 1 ATOM 2374 C CD2 . PHE A 1 290 ? 28.446 -13.387 -21.791 1.00 22.27 ? 307 PHE A CD2 1 ATOM 2375 C CE1 . PHE A 1 290 ? 28.032 -12.582 -19.175 1.00 22.81 ? 307 PHE A CE1 1 ATOM 2376 C CE2 . PHE A 1 290 ? 27.612 -12.301 -21.523 1.00 22.45 ? 307 PHE A CE2 1 ATOM 2377 C CZ . PHE A 1 290 ? 27.400 -11.904 -20.216 1.00 21.98 ? 307 PHE A CZ 1 ATOM 2378 N N . THR A 1 291 ? 32.530 -16.978 -21.795 1.00 24.04 ? 308 THR A N 1 ATOM 2379 C CA . THR A 1 291 ? 33.363 -18.188 -21.650 1.00 24.00 ? 308 THR A CA 1 ATOM 2380 C C . THR A 1 291 ? 34.826 -17.840 -21.342 1.00 24.26 ? 308 THR A C 1 ATOM 2381 O O . THR A 1 291 ? 35.478 -18.579 -20.608 1.00 23.77 ? 308 THR A O 1 ATOM 2382 C CB . THR A 1 291 ? 33.293 -19.129 -22.869 1.00 24.81 ? 308 THR A CB 1 ATOM 2383 O OG1 . THR A 1 291 ? 33.730 -18.436 -24.039 1.00 24.84 ? 308 THR A OG1 1 ATOM 2384 C CG2 . THR A 1 291 ? 31.882 -19.642 -23.076 1.00 25.56 ? 308 THR A CG2 1 ATOM 2385 N N . SER A 1 292 ? 35.320 -16.701 -21.842 1.00 23.95 ? 309 SER A N 1 ATOM 2386 C CA . SER A 1 292 ? 36.673 -16.219 -21.497 1.00 24.87 ? 309 SER A CA 1 ATOM 2387 C C . SER A 1 292 ? 36.846 -15.946 -20.001 1.00 26.11 ? 309 SER A C 1 ATOM 2388 O O . SER A 1 292 ? 37.951 -16.053 -19.476 1.00 26.02 ? 309 SER A O 1 ATOM 2389 C CB . SER A 1 292 ? 37.054 -14.954 -22.283 1.00 24.79 ? 309 SER A CB 1 ATOM 2390 O OG . SER A 1 292 ? 36.546 -13.768 -21.680 1.00 24.16 ? 309 SER A OG 1 ATOM 2391 N N . MET A 1 293 ? 35.752 -15.596 -19.327 1.00 25.51 ? 310 MET A N 1 ATOM 2392 C CA . MET A 1 293 ? 35.751 -15.384 -17.879 1.00 26.35 ? 310 MET A CA 1 ATOM 2393 C C . MET A 1 293 ? 35.432 -16.668 -17.105 1.00 26.89 ? 310 MET A C 1 ATOM 2394 O O . MET A 1 293 ? 35.203 -16.616 -15.898 1.00 26.55 ? 310 MET A O 1 ATOM 2395 C CB . MET A 1 293 ? 34.733 -14.300 -17.523 1.00 26.89 ? 310 MET A CB 1 ATOM 2396 C CG . MET A 1 293 ? 35.040 -12.954 -18.151 1.00 27.81 ? 310 MET A CG 1 ATOM 2397 S SD . MET A 1 293 ? 33.701 -11.768 -17.939 1.00 28.73 ? 310 MET A SD 1 ATOM 2398 C CE . MET A 1 293 ? 33.740 -11.558 -16.165 1.00 28.72 ? 310 MET A CE 1 ATOM 2399 N N . ASN A 1 294 ? 35.433 -17.811 -17.788 1.00 27.08 ? 311 ASN A N 1 ATOM 2400 C CA . ASN A 1 294 ? 35.060 -19.093 -17.207 1.00 28.71 ? 311 ASN A CA 1 ATOM 2401 C C . ASN A 1 294 ? 33.591 -19.133 -16.723 1.00 28.73 ? 311 ASN A C 1 ATOM 2402 O O . ASN A 1 294 ? 33.241 -19.861 -15.789 1.00 28.47 ? 311 ASN A O 1 ATOM 2403 C CB . ASN A 1 294 ? 36.066 -19.472 -16.106 1.00 30.62 ? 311 ASN A CB 1 ATOM 2404 C CG . ASN A 1 294 ? 35.913 -20.899 -15.638 1.00 33.38 ? 311 ASN A CG 1 ATOM 2405 O OD1 . ASN A 1 294 ? 35.679 -21.809 -16.433 1.00 31.98 ? 311 ASN A OD1 1 ATOM 2406 N ND2 . ASN A 1 294 ? 36.038 -21.098 -14.315 1.00 38.08 ? 311 ASN A ND2 1 ATOM 2407 N N . LEU A 1 295 ? 32.731 -18.366 -17.393 1.00 26.13 ? 312 LEU A N 1 ATOM 2408 C CA . LEU A 1 295 ? 31.293 -18.433 -17.166 1.00 25.44 ? 312 LEU A CA 1 ATOM 2409 C C . LEU A 1 295 ? 30.666 -19.322 -18.231 1.00 25.59 ? 312 LEU A C 1 ATOM 2410 O O . LEU A 1 295 ? 31.368 -19.853 -19.100 1.00 26.78 ? 312 LEU A O 1 ATOM 2411 C CB . LEU A 1 295 ? 30.700 -17.023 -17.134 1.00 25.17 ? 312 LEU A CB 1 ATOM 2412 C CG . LEU A 1 295 ? 31.126 -16.220 -15.901 1.00 25.09 ? 312 LEU A CG 1 ATOM 2413 C CD1 . LEU A 1 295 ? 30.739 -14.759 -16.063 1.00 25.17 ? 312 LEU A CD1 1 ATOM 2414 C CD2 . LEU A 1 295 ? 30.542 -16.811 -14.625 1.00 25.23 ? 312 LEU A CD2 1 ATOM 2415 N N . THR A 1 296 ? 29.355 -19.510 -18.152 1.00 24.63 ? 313 THR A N 1 ATOM 2416 C CA . THR A 1 296 ? 28.679 -20.569 -18.887 1.00 24.96 ? 313 THR A CA 1 ATOM 2417 C C . THR A 1 296 ? 28.463 -20.213 -20.351 1.00 26.57 ? 313 THR A C 1 ATOM 2418 O O . THR A 1 296 ? 27.990 -19.126 -20.667 1.00 24.86 ? 313 THR A O 1 ATOM 2419 C CB . THR A 1 296 ? 27.333 -20.879 -18.227 1.00 24.36 ? 313 THR A CB 1 ATOM 2420 O OG1 . THR A 1 296 ? 27.566 -21.127 -16.839 1.00 24.27 ? 313 THR A OG1 1 ATOM 2421 C CG2 . THR A 1 296 ? 26.654 -22.090 -18.858 1.00 24.09 ? 313 THR A CG2 1 ATOM 2422 N N . LYS A 1 297 ? 28.819 -21.152 -21.225 1.00 27.66 ? 314 LYS A N 1 ATOM 2423 C CA . LYS A 1 297 ? 28.626 -21.027 -22.664 1.00 28.66 ? 314 LYS A CA 1 ATOM 2424 C C . LYS A 1 297 ? 27.136 -21.146 -22.978 1.00 26.13 ? 314 LYS A C 1 ATOM 2425 O O . LYS A 1 297 ? 26.400 -21.820 -22.264 1.00 24.27 ? 314 LYS A O 1 ATOM 2426 C CB . LYS A 1 297 ? 29.408 -22.145 -23.364 1.00 33.15 ? 314 LYS A CB 1 ATOM 2427 C CG . LYS A 1 297 ? 29.406 -22.086 -24.885 1.00 38.11 ? 314 LYS A CG 1 ATOM 2428 C CD . LYS A 1 297 ? 30.049 -23.320 -25.518 1.00 42.30 ? 314 LYS A CD 1 ATOM 2429 C CE . LYS A 1 297 ? 29.295 -24.602 -25.180 1.00 45.06 ? 314 LYS A CE 1 ATOM 2430 N NZ . LYS A 1 297 ? 29.369 -25.610 -26.279 1.00 48.36 ? 314 LYS A NZ 1 ATOM 2431 N N . LEU A 1 298 ? 26.689 -20.476 -24.033 1.00 25.60 ? 315 LEU A N 1 ATOM 2432 C CA . LEU A 1 298 ? 25.289 -20.539 -24.441 1.00 25.46 ? 315 LEU A CA 1 ATOM 2433 C C . LEU A 1 298 ? 24.929 -21.963 -24.880 1.00 26.01 ? 315 LEU A C 1 ATOM 2434 O O . LEU A 1 298 ? 25.698 -22.594 -25.606 1.00 24.88 ? 315 LEU A O 1 ATOM 2435 C CB . LEU A 1 298 ? 24.991 -19.545 -25.570 1.00 25.72 ? 315 LEU A CB 1 ATOM 2436 C CG . LEU A 1 298 ? 25.033 -18.073 -25.135 1.00 25.66 ? 315 LEU A CG 1 ATOM 2437 C CD1 . LEU A 1 298 ? 25.072 -17.151 -26.338 1.00 26.03 ? 315 LEU A CD1 1 ATOM 2438 C CD2 . LEU A 1 298 ? 23.861 -17.710 -24.236 1.00 25.62 ? 315 LEU A CD2 1 ATOM 2439 N N . PRO A 1 299 ? 23.775 -22.477 -24.422 1.00 26.49 ? 316 PRO A N 1 ATOM 2440 C CA . PRO A 1 299 ? 23.362 -23.825 -24.808 1.00 26.50 ? 316 PRO A CA 1 ATOM 2441 C C . PRO A 1 299 ? 22.778 -23.866 -26.213 1.00 26.78 ? 316 PRO A C 1 ATOM 2442 O O . PRO A 1 299 ? 22.443 -22.823 -26.787 1.00 25.26 ? 316 PRO A O 1 ATOM 2443 C CB . PRO A 1 299 ? 22.286 -24.157 -23.778 1.00 27.02 ? 316 PRO A CB 1 ATOM 2444 C CG . PRO A 1 299 ? 21.661 -22.841 -23.471 1.00 27.16 ? 316 PRO A CG 1 ATOM 2445 C CD . PRO A 1 299 ? 22.777 -21.835 -23.544 1.00 26.84 ? 316 PRO A CD 1 ATOM 2446 N N . GLN A 1 300 ? 22.629 -25.073 -26.745 1.00 27.22 ? 317 GLN A N 1 ATOM 2447 C CA . GLN A 1 300 ? 22.161 -25.266 -28.119 1.00 28.34 ? 317 GLN A CA 1 ATOM 2448 C C . GLN A 1 300 ? 20.779 -24.664 -28.381 1.00 26.99 ? 317 GLN A C 1 ATOM 2449 O O . GLN A 1 300 ? 20.561 -24.056 -29.430 1.00 26.68 ? 317 GLN A O 1 ATOM 2450 C CB . GLN A 1 300 ? 22.160 -26.763 -28.485 1.00 30.57 ? 317 GLN A CB 1 ATOM 2451 C CG . GLN A 1 300 ? 22.023 -27.049 -29.978 1.00 32.66 ? 317 GLN A CG 1 ATOM 2452 C CD . GLN A 1 300 ? 23.135 -26.404 -30.790 1.00 33.86 ? 317 GLN A CD 1 ATOM 2453 O OE1 . GLN A 1 300 ? 24.312 -26.607 -30.503 1.00 36.83 ? 317 GLN A OE1 1 ATOM 2454 N NE2 . GLN A 1 300 ? 22.767 -25.594 -31.784 1.00 34.38 ? 317 GLN A NE2 1 ATOM 2455 N N . ASP A 1 301 ? 19.856 -24.834 -27.433 1.00 26.75 ? 318 ASP A N 1 ATOM 2456 C CA . ASP A 1 301 ? 18.523 -24.202 -27.498 1.00 26.85 ? 318 ASP A CA 1 ATOM 2457 C C . ASP A 1 301 ? 18.551 -22.707 -27.800 1.00 25.01 ? 318 ASP A C 1 ATOM 2458 O O . ASP A 1 301 ? 17.648 -22.200 -28.475 1.00 23.84 ? 318 ASP A O 1 ATOM 2459 C CB . ASP A 1 301 ? 17.755 -24.381 -26.178 1.00 29.32 ? 318 ASP A CB 1 ATOM 2460 C CG . ASP A 1 301 ? 16.915 -25.630 -26.134 1.00 31.64 ? 318 ASP A CG 1 ATOM 2461 O OD1 . ASP A 1 301 ? 16.930 -26.435 -27.091 1.00 34.77 ? 318 ASP A OD1 1 ATOM 2462 O OD2 . ASP A 1 301 ? 16.220 -25.804 -25.111 1.00 32.96 ? 318 ASP A OD2 1 ATOM 2463 N N . PHE A 1 302 ? 19.553 -22.001 -27.272 1.00 23.55 ? 319 PHE A N 1 ATOM 2464 C CA . PHE A 1 302 ? 19.677 -20.562 -27.514 1.00 23.30 ? 319 PHE A CA 1 ATOM 2465 C C . PHE A 1 302 ? 19.851 -20.266 -28.998 1.00 23.92 ? 319 PHE A C 1 ATOM 2466 O O . PHE A 1 302 ? 19.164 -19.407 -29.561 1.00 23.70 ? 319 PHE A O 1 ATOM 2467 C CB . PHE A 1 302 ? 20.855 -19.954 -26.746 1.00 22.94 ? 319 PHE A CB 1 ATOM 2468 C CG . PHE A 1 302 ? 21.041 -18.490 -27.021 1.00 22.47 ? 319 PHE A CG 1 ATOM 2469 C CD1 . PHE A 1 302 ? 21.828 -18.062 -28.088 1.00 22.66 ? 319 PHE A CD1 1 ATOM 2470 C CD2 . PHE A 1 302 ? 20.379 -17.536 -26.253 1.00 22.70 ? 319 PHE A CD2 1 ATOM 2471 C CE1 . PHE A 1 302 ? 21.972 -16.713 -28.366 1.00 22.16 ? 319 PHE A CE1 1 ATOM 2472 C CE2 . PHE A 1 302 ? 20.524 -16.184 -26.527 1.00 22.30 ? 319 PHE A CE2 1 ATOM 2473 C CZ . PHE A 1 302 ? 21.328 -15.774 -27.584 1.00 22.74 ? 319 PHE A CZ 1 ATOM 2474 N N . TRP A 1 303 ? 20.791 -20.970 -29.614 1.00 23.89 ? 320 TRP A N 1 ATOM 2475 C CA . TRP A 1 303 ? 21.074 -20.786 -31.029 1.00 24.65 ? 320 TRP A CA 1 ATOM 2476 C C . TRP A 1 303 ? 19.904 -21.227 -31.906 1.00 25.78 ? 320 TRP A C 1 ATOM 2477 O O . TRP A 1 303 ? 19.562 -20.547 -32.873 1.00 25.95 ? 320 TRP A O 1 ATOM 2478 C CB . TRP A 1 303 ? 22.350 -21.532 -31.414 1.00 25.16 ? 320 TRP A CB 1 ATOM 2479 C CG . TRP A 1 303 ? 23.563 -21.060 -30.660 1.00 24.61 ? 320 TRP A CG 1 ATOM 2480 C CD1 . TRP A 1 303 ? 24.310 -21.782 -29.781 1.00 24.82 ? 320 TRP A CD1 1 ATOM 2481 C CD2 . TRP A 1 303 ? 24.157 -19.755 -30.715 1.00 24.78 ? 320 TRP A CD2 1 ATOM 2482 N NE1 . TRP A 1 303 ? 25.337 -21.014 -29.286 1.00 24.74 ? 320 TRP A NE1 1 ATOM 2483 C CE2 . TRP A 1 303 ? 25.273 -19.768 -29.851 1.00 24.63 ? 320 TRP A CE2 1 ATOM 2484 C CE3 . TRP A 1 303 ? 23.863 -18.580 -31.425 1.00 24.72 ? 320 TRP A CE3 1 ATOM 2485 C CZ2 . TRP A 1 303 ? 26.095 -18.649 -29.665 1.00 25.09 ? 320 TRP A CZ2 1 ATOM 2486 C CZ3 . TRP A 1 303 ? 24.680 -17.467 -31.247 1.00 24.98 ? 320 TRP A CZ3 1 ATOM 2487 C CH2 . TRP A 1 303 ? 25.783 -17.507 -30.367 1.00 25.11 ? 320 TRP A CH2 1 ATOM 2488 N N . ASP A 1 304 ? 19.279 -22.350 -31.559 1.00 26.99 ? 321 ASP A N 1 ATOM 2489 C CA . ASP A 1 304 ? 18.178 -22.897 -32.359 1.00 27.66 ? 321 ASP A CA 1 ATOM 2490 C C . ASP A 1 304 ? 16.899 -22.059 -32.322 1.00 26.84 ? 321 ASP A C 1 ATOM 2491 O O . ASP A 1 304 ? 16.164 -22.026 -33.308 1.00 27.58 ? 321 ASP A O 1 ATOM 2492 C CB . ASP A 1 304 ? 17.829 -24.328 -31.915 1.00 29.24 ? 321 ASP A CB 1 ATOM 2493 C CG . ASP A 1 304 ? 18.989 -25.311 -32.080 1.00 30.81 ? 321 ASP A CG 1 ATOM 2494 O OD1 . ASP A 1 304 ? 20.004 -24.984 -32.731 1.00 31.79 ? 321 ASP A OD1 1 ATOM 2495 O OD2 . ASP A 1 304 ? 18.875 -26.427 -31.536 1.00 32.70 ? 321 ASP A OD2 1 ATOM 2496 N N . LYS A 1 305 ? 16.617 -21.399 -31.201 1.00 25.90 ? 322 LYS A N 1 ATOM 2497 C CA . LYS A 1 305 ? 15.299 -20.774 -30.998 1.00 26.58 ? 322 LYS A CA 1 ATOM 2498 C C . LYS A 1 305 ? 15.296 -19.252 -30.858 1.00 24.58 ? 322 LYS A C 1 ATOM 2499 O O . LYS A 1 305 ? 14.228 -18.650 -30.891 1.00 23.65 ? 322 LYS A O 1 ATOM 2500 C CB . LYS A 1 305 ? 14.613 -21.401 -29.777 1.00 28.74 ? 322 LYS A CB 1 ATOM 2501 C CG . LYS A 1 305 ? 14.627 -22.924 -29.789 1.00 31.10 ? 322 LYS A CG 1 ATOM 2502 C CD . LYS A 1 305 ? 13.750 -23.510 -28.692 1.00 33.65 ? 322 LYS A CD 1 ATOM 2503 C CE . LYS A 1 305 ? 13.605 -25.020 -28.858 1.00 35.86 ? 322 LYS A CE 1 ATOM 2504 N NZ . LYS A 1 305 ? 12.376 -25.510 -28.185 1.00 37.84 ? 322 LYS A NZ 1 ATOM 2505 N N . SER A 1 306 ? 16.462 -18.627 -30.692 1.00 23.95 ? 323 SER A N 1 ATOM 2506 C CA . SER A 1 306 ? 16.529 -17.161 -30.600 1.00 22.85 ? 323 SER A CA 1 ATOM 2507 C C . SER A 1 306 ? 16.167 -16.518 -31.940 1.00 23.69 ? 323 SER A C 1 ATOM 2508 O O . SER A 1 306 ? 16.286 -17.145 -32.992 1.00 22.50 ? 323 SER A O 1 ATOM 2509 C CB . SER A 1 306 ? 17.915 -16.697 -30.160 1.00 22.69 ? 323 SER A CB 1 ATOM 2510 O OG . SER A 1 306 ? 18.165 -17.072 -28.818 1.00 21.97 ? 323 SER A OG 1 ATOM 2511 N N . ILE A 1 307 ? 15.694 -15.280 -31.875 1.00 23.03 ? 324 ILE A N 1 ATOM 2512 C CA . ILE A 1 307 ? 15.423 -14.469 -33.051 1.00 23.44 ? 324 ILE A CA 1 ATOM 2513 C C . ILE A 1 307 ? 16.363 -13.284 -32.922 1.00 22.96 ? 324 ILE A C 1 ATOM 2514 O O . ILE A 1 307 ? 16.192 -12.450 -32.034 1.00 21.13 ? 324 ILE A O 1 ATOM 2515 C CB . ILE A 1 307 ? 13.948 -14.011 -33.104 1.00 24.39 ? 324 ILE A CB 1 ATOM 2516 C CG1 . ILE A 1 307 ? 13.024 -15.223 -33.305 1.00 25.17 ? 324 ILE A CG1 1 ATOM 2517 C CG2 . ILE A 1 307 ? 13.730 -12.994 -34.227 1.00 25.27 ? 324 ILE A CG2 1 ATOM 2518 C CD1 . ILE A 1 307 ? 11.561 -14.941 -33.017 1.00 25.40 ? 324 ILE A CD1 1 ATOM 2519 N N . ILE A 1 308 ? 17.372 -13.234 -33.788 1.00 22.95 ? 325 ILE A N 1 ATOM 2520 C CA . ILE A 1 308 ? 18.439 -12.234 -33.672 1.00 23.78 ? 325 ILE A CA 1 ATOM 2521 C C . ILE A 1 308 ? 18.517 -11.237 -34.828 1.00 24.26 ? 325 ILE A C 1 ATOM 2522 O O . ILE A 1 308 ? 19.448 -10.436 -34.891 1.00 24.29 ? 325 ILE A O 1 ATOM 2523 C CB . ILE A 1 308 ? 19.806 -12.899 -33.413 1.00 23.73 ? 325 ILE A CB 1 ATOM 2524 C CG1 . ILE A 1 308 ? 20.258 -13.781 -34.584 1.00 24.37 ? 325 ILE A CG1 1 ATOM 2525 C CG2 . ILE A 1 308 ? 19.739 -13.719 -32.134 1.00 24.47 ? 325 ILE A CG2 1 ATOM 2526 C CD1 . ILE A 1 308 ? 21.695 -14.243 -34.442 1.00 24.67 ? 325 ILE A CD1 1 ATOM 2527 N N . GLU A 1 309 ? 17.531 -11.262 -35.711 1.00 25.58 ? 326 GLU A N 1 ATOM 2528 C CA . GLU A 1 309 ? 17.341 -10.196 -36.687 1.00 27.25 ? 326 GLU A CA 1 ATOM 2529 C C . GLU A 1 309 ? 15.861 -10.005 -36.938 1.00 26.03 ? 326 GLU A C 1 ATOM 2530 O O . GLU A 1 309 ? 15.054 -10.921 -36.721 1.00 24.93 ? 326 GLU A O 1 ATOM 2531 C CB . GLU A 1 309 ? 18.084 -10.499 -37.987 1.00 31.33 ? 326 GLU A CB 1 ATOM 2532 C CG . GLU A 1 309 ? 17.716 -11.812 -38.645 1.00 34.55 ? 326 GLU A CG 1 ATOM 2533 C CD . GLU A 1 309 ? 18.942 -12.590 -39.085 1.00 40.96 ? 326 GLU A CD 1 ATOM 2534 O OE1 . GLU A 1 309 ? 19.709 -12.061 -39.928 1.00 42.20 ? 326 GLU A OE1 1 ATOM 2535 O OE2 . GLU A 1 309 ? 19.148 -13.715 -38.563 1.00 43.36 ? 326 GLU A OE2 1 ATOM 2536 N N . LYS A 1 310 ? 15.504 -8.804 -37.378 1.00 24.65 ? 327 LYS A N 1 ATOM 2537 C CA . LYS A 1 310 ? 14.113 -8.475 -37.646 1.00 25.07 ? 327 LYS A CA 1 ATOM 2538 C C . LYS A 1 310 ? 13.580 -9.404 -38.743 1.00 25.78 ? 327 LYS A C 1 ATOM 2539 O O . LYS A 1 310 ? 14.251 -9.589 -39.754 1.00 25.56 ? 327 LYS A O 1 ATOM 2540 C CB . LYS A 1 310 ? 13.973 -7.009 -38.081 1.00 25.14 ? 327 LYS A CB 1 ATOM 2541 C CG . LYS A 1 310 ? 12.533 -6.528 -38.130 1.00 25.55 ? 327 LYS A CG 1 ATOM 2542 C CD . LYS A 1 310 ? 12.416 -5.027 -38.332 1.00 25.78 ? 327 LYS A CD 1 ATOM 2543 C CE . LYS A 1 310 ? 10.951 -4.618 -38.275 1.00 27.01 ? 327 LYS A CE 1 ATOM 2544 N NZ . LYS A 1 310 ? 10.728 -3.195 -38.655 1.00 27.17 ? 327 LYS A NZ 1 ATOM 2545 N N . PRO A 1 311 ? 12.401 -10.022 -38.532 1.00 26.15 ? 328 PRO A N 1 ATOM 2546 C CA . PRO A 1 311 ? 11.766 -10.775 -39.627 1.00 27.40 ? 328 PRO A CA 1 ATOM 2547 C C . PRO A 1 311 ? 11.539 -9.901 -40.866 1.00 28.60 ? 328 PRO A C 1 ATOM 2548 O O . PRO A 1 311 ? 11.357 -8.693 -40.731 1.00 28.24 ? 328 PRO A O 1 ATOM 2549 C CB . PRO A 1 311 ? 10.424 -11.209 -39.030 1.00 27.81 ? 328 PRO A CB 1 ATOM 2550 C CG . PRO A 1 311 ? 10.627 -11.203 -37.560 1.00 27.74 ? 328 PRO A CG 1 ATOM 2551 C CD . PRO A 1 311 ? 11.672 -10.171 -37.260 1.00 26.93 ? 328 PRO A CD 1 ATOM 2552 N N . THR A 1 312 ? 11.583 -10.509 -42.049 1.00 30.66 ? 329 THR A N 1 ATOM 2553 C CA . THR A 1 312 ? 11.387 -9.803 -43.321 1.00 33.06 ? 329 THR A CA 1 ATOM 2554 C C . THR A 1 312 ? 10.053 -10.130 -44.002 1.00 35.50 ? 329 THR A C 1 ATOM 2555 O O . THR A 1 312 ? 9.820 -9.709 -45.130 1.00 38.33 ? 329 THR A O 1 ATOM 2556 C CB . THR A 1 312 ? 12.529 -10.130 -44.300 1.00 33.21 ? 329 THR A CB 1 ATOM 2557 O OG1 . THR A 1 312 ? 12.609 -11.548 -44.484 1.00 32.79 ? 329 THR A OG1 1 ATOM 2558 C CG2 . THR A 1 312 ? 13.851 -9.609 -43.764 1.00 33.99 ? 329 THR A CG2 1 ATOM 2559 N N . ASP A 1 313 ? 9.176 -10.857 -43.314 1.00 36.45 ? 330 ASP A N 1 ATOM 2560 C CA . ASP A 1 313 ? 7.857 -11.217 -43.854 1.00 37.58 ? 330 ASP A CA 1 ATOM 2561 C C . ASP A 1 313 ? 6.779 -10.141 -43.620 1.00 38.54 ? 330 ASP A C 1 ATOM 2562 O O . ASP A 1 313 ? 5.636 -10.328 -44.013 1.00 39.88 ? 330 ASP A O 1 ATOM 2563 C CB . ASP A 1 313 ? 7.393 -12.571 -43.289 1.00 38.63 ? 330 ASP A CB 1 ATOM 2564 C CG . ASP A 1 313 ? 7.340 -12.595 -41.759 1.00 39.35 ? 330 ASP A CG 1 ATOM 2565 O OD1 . ASP A 1 313 ? 7.432 -11.509 -41.144 1.00 37.18 ? 330 ASP A OD1 1 ATOM 2566 O OD2 . ASP A 1 313 ? 7.223 -13.696 -41.179 1.00 39.08 ? 330 ASP A OD2 1 ATOM 2567 N N . GLY A 1 314 ? 7.132 -9.036 -42.962 1.00 38.21 ? 331 GLY A N 1 ATOM 2568 C CA . GLY A 1 314 ? 6.198 -7.937 -42.749 1.00 37.27 ? 331 GLY A CA 1 ATOM 2569 C C . GLY A 1 314 ? 5.132 -8.163 -41.684 1.00 36.84 ? 331 GLY A C 1 ATOM 2570 O O . GLY A 1 314 ? 4.157 -7.410 -41.625 1.00 37.04 ? 331 GLY A O 1 ATOM 2571 N N . ARG A 1 315 ? 5.302 -9.178 -40.835 1.00 34.12 ? 332 ARG A N 1 ATOM 2572 C CA . ARG A 1 315 ? 4.410 -9.347 -39.682 1.00 33.45 ? 332 ARG A CA 1 ATOM 2573 C C . ARG A 1 315 ? 4.679 -8.237 -38.673 1.00 30.33 ? 332 ARG A C 1 ATOM 2574 O O . ARG A 1 315 ? 5.692 -7.549 -38.756 1.00 28.99 ? 332 ARG A O 1 ATOM 2575 C CB . ARG A 1 315 ? 4.624 -10.697 -39.017 1.00 33.82 ? 332 ARG A CB 1 ATOM 2576 C CG . ARG A 1 315 ? 5.888 -10.804 -38.179 1.00 36.61 ? 332 ARG A CG 1 ATOM 2577 C CD . ARG A 1 315 ? 6.535 -12.159 -38.376 1.00 38.61 ? 332 ARG A CD 1 ATOM 2578 N NE . ARG A 1 315 ? 7.225 -12.663 -37.213 1.00 39.19 ? 332 ARG A NE 1 ATOM 2579 C CZ . ARG A 1 315 ? 8.084 -13.677 -37.238 1.00 38.40 ? 332 ARG A CZ 1 ATOM 2580 N NH1 . ARG A 1 315 ? 8.379 -14.305 -38.377 1.00 39.08 ? 332 ARG A NH1 1 ATOM 2581 N NH2 . ARG A 1 315 ? 8.666 -14.054 -36.106 1.00 38.62 ? 332 ARG A NH2 1 ATOM 2582 N N . ASP A 1 316 ? 3.777 -8.080 -37.722 1.00 28.86 ? 333 ASP A N 1 ATOM 2583 C CA . ASP A 1 316 ? 4.021 -7.200 -36.590 1.00 28.44 ? 333 ASP A CA 1 ATOM 2584 C C . ASP A 1 316 ? 4.667 -7.994 -35.464 1.00 26.76 ? 333 ASP A C 1 ATOM 2585 O O . ASP A 1 316 ? 4.317 -9.155 -35.230 1.00 26.78 ? 333 ASP A O 1 ATOM 2586 C CB . ASP A 1 316 ? 2.715 -6.566 -36.121 1.00 29.67 ? 333 ASP A CB 1 ATOM 2587 C CG . ASP A 1 316 ? 2.158 -5.591 -37.133 1.00 32.76 ? 333 ASP A CG 1 ATOM 2588 O OD1 . ASP A 1 316 ? 2.885 -4.632 -37.498 1.00 34.60 ? 333 ASP A OD1 1 ATOM 2589 O OD2 . ASP A 1 316 ? 0.997 -5.782 -37.546 1.00 34.29 ? 333 ASP A OD2 1 ATOM 2590 N N . LEU A 1 317 ? 5.604 -7.364 -34.770 1.00 24.90 ? 334 LEU A N 1 ATOM 2591 C CA . LEU A 1 317 ? 6.244 -7.953 -33.590 1.00 24.49 ? 334 LEU A CA 1 ATOM 2592 C C . LEU A 1 317 ? 6.724 -6.841 -32.675 1.00 24.23 ? 334 LEU A C 1 ATOM 2593 O O . LEU A 1 317 ? 6.729 -5.677 -33.070 1.00 22.48 ? 334 LEU A O 1 ATOM 2594 C CB . LEU A 1 317 ? 7.428 -8.844 -33.981 1.00 24.96 ? 334 LEU A CB 1 ATOM 2595 C CG . LEU A 1 317 ? 8.725 -8.177 -34.459 1.00 25.89 ? 334 LEU A CG 1 ATOM 2596 C CD1 . LEU A 1 317 ? 9.913 -9.097 -34.240 1.00 26.55 ? 334 LEU A CD1 1 ATOM 2597 C CD2 . LEU A 1 317 ? 8.615 -7.762 -35.916 1.00 25.79 ? 334 LEU A CD2 1 ATOM 2598 N N . VAL A 1 318 ? 7.138 -7.223 -31.468 1.00 23.38 ? 335 VAL A N 1 ATOM 2599 C CA . VAL A 1 318 ? 7.829 -6.328 -30.564 1.00 23.72 ? 335 VAL A CA 1 ATOM 2600 C C . VAL A 1 318 ? 9.315 -6.454 -30.887 1.00 23.31 ? 335 VAL A C 1 ATOM 2601 O O . VAL A 1 318 ? 9.906 -7.518 -30.672 1.00 22.16 ? 335 VAL A O 1 ATOM 2602 C CB . VAL A 1 318 ? 7.536 -6.691 -29.095 1.00 24.31 ? 335 VAL A CB 1 ATOM 2603 C CG1 . VAL A 1 318 ? 8.345 -5.823 -28.141 1.00 23.97 ? 335 VAL A CG1 1 ATOM 2604 C CG2 . VAL A 1 318 ? 6.040 -6.543 -28.819 1.00 24.97 ? 335 VAL A CG2 1 ATOM 2605 N N . CYS A 1 319 ? 9.913 -5.390 -31.426 1.00 22.98 ? 336 CYS A N 1 ATOM 2606 C CA . CYS A 1 319 ? 11.357 -5.401 -31.711 1.00 24.09 ? 336 CYS A CA 1 ATOM 2607 C C . CYS A 1 319 ? 12.206 -5.004 -30.507 1.00 24.59 ? 336 CYS A C 1 ATOM 2608 O O . CYS A 1 319 ? 13.415 -5.227 -30.524 1.00 26.04 ? 336 CYS A O 1 ATOM 2609 C CB . CYS A 1 319 ? 11.730 -4.529 -32.932 1.00 24.77 ? 336 CYS A CB 1 ATOM 2610 S SG . CYS A 1 319 ? 11.931 -5.466 -34.479 1.00 26.12 ? 336 CYS A SG 1 ATOM 2611 N N . HIS A 1 320 ? 11.606 -4.417 -29.472 1.00 23.92 ? 337 HIS A N 1 ATOM 2612 C CA . HIS A 1 320 ? 12.379 -4.048 -28.294 1.00 23.90 ? 337 HIS A CA 1 ATOM 2613 C C . HIS A 1 320 ? 13.142 -5.266 -27.769 1.00 22.67 ? 337 HIS A C 1 ATOM 2614 O O . HIS A 1 320 ? 12.532 -6.289 -27.481 1.00 22.74 ? 337 HIS A O 1 ATOM 2615 C CB . HIS A 1 320 ? 11.486 -3.490 -27.193 1.00 25.87 ? 337 HIS A CB 1 ATOM 2616 C CG . HIS A 1 320 ? 12.260 -2.961 -26.035 1.00 27.01 ? 337 HIS A CG 1 ATOM 2617 N ND1 . HIS A 1 320 ? 12.785 -1.688 -26.018 1.00 29.15 ? 337 HIS A ND1 1 ATOM 2618 C CD2 . HIS A 1 320 ? 12.650 -3.550 -24.881 1.00 28.51 ? 337 HIS A CD2 1 ATOM 2619 C CE1 . HIS A 1 320 ? 13.456 -1.511 -24.895 1.00 29.11 ? 337 HIS A CE1 1 ATOM 2620 N NE2 . HIS A 1 320 ? 13.390 -2.625 -24.189 1.00 29.35 ? 337 HIS A NE2 1 ATOM 2621 N N . ALA A 1 321 ? 14.468 -5.152 -27.687 1.00 21.48 ? 338 ALA A N 1 ATOM 2622 C CA . ALA A 1 321 ? 15.340 -6.278 -27.346 1.00 21.16 ? 338 ALA A CA 1 ATOM 2623 C C . ALA A 1 321 ? 14.991 -6.878 -25.988 1.00 20.59 ? 338 ALA A C 1 ATOM 2624 O O . ALA A 1 321 ? 14.677 -6.154 -25.038 1.00 20.28 ? 338 ALA A O 1 ATOM 2625 C CB . ALA A 1 321 ? 16.798 -5.841 -27.349 1.00 21.57 ? 338 ALA A CB 1 ATOM 2626 N N . SER A 1 322 ? 15.043 -8.203 -25.903 1.00 20.86 ? 339 SER A N 1 ATOM 2627 C CA . SER A 1 322 ? 14.660 -8.889 -24.674 1.00 20.87 ? 339 SER A CA 1 ATOM 2628 C C . SER A 1 322 ? 15.259 -10.282 -24.573 1.00 20.24 ? 339 SER A C 1 ATOM 2629 O O . SER A 1 322 ? 15.612 -10.898 -25.584 1.00 20.67 ? 339 SER A O 1 ATOM 2630 C CB . SER A 1 322 ? 13.140 -8.962 -24.560 1.00 20.95 ? 339 SER A CB 1 ATOM 2631 O OG . SER A 1 322 ? 12.579 -9.651 -25.666 1.00 21.66 ? 339 SER A OG 1 ATOM 2632 N N . ALA A 1 323 ? 15.360 -10.744 -23.332 1.00 19.20 ? 340 ALA A N 1 ATOM 2633 C CA . ALA A 1 323 ? 15.937 -12.034 -22.976 1.00 19.12 ? 340 ALA A CA 1 ATOM 2634 C C . ALA A 1 323 ? 14.901 -12.817 -22.188 1.00 18.92 ? 340 ALA A C 1 ATOM 2635 O O . ALA A 1 323 ? 14.212 -12.254 -21.319 1.00 18.37 ? 340 ALA A O 1 ATOM 2636 C CB . ALA A 1 323 ? 17.194 -11.824 -22.147 1.00 19.19 ? 340 ALA A CB 1 ATOM 2637 N N . TRP A 1 324 ? 14.805 -14.114 -22.482 1.00 19.41 ? 341 TRP A N 1 ATOM 2638 C CA . TRP A 1 324 ? 13.693 -14.961 -22.029 1.00 19.67 ? 341 TRP A CA 1 ATOM 2639 C C . TRP A 1 324 ? 14.203 -16.227 -21.365 1.00 19.41 ? 341 TRP A C 1 ATOM 2640 O O . TRP A 1 324 ? 15.028 -16.952 -21.932 1.00 19.19 ? 341 TRP A O 1 ATOM 2641 C CB . TRP A 1 324 ? 12.816 -15.356 -23.219 1.00 20.78 ? 341 TRP A CB 1 ATOM 2642 C CG . TRP A 1 324 ? 12.185 -14.188 -23.902 1.00 22.31 ? 341 TRP A CG 1 ATOM 2643 C CD1 . TRP A 1 324 ? 12.816 -13.230 -24.652 1.00 23.37 ? 341 TRP A CD1 1 ATOM 2644 C CD2 . TRP A 1 324 ? 10.799 -13.851 -23.902 1.00 23.67 ? 341 TRP A CD2 1 ATOM 2645 N NE1 . TRP A 1 324 ? 11.899 -12.313 -25.114 1.00 23.48 ? 341 TRP A NE1 1 ATOM 2646 C CE2 . TRP A 1 324 ? 10.654 -12.673 -24.668 1.00 24.29 ? 341 TRP A CE2 1 ATOM 2647 C CE3 . TRP A 1 324 ? 9.661 -14.430 -23.327 1.00 24.25 ? 341 TRP A CE3 1 ATOM 2648 C CZ2 . TRP A 1 324 ? 9.418 -12.064 -24.873 1.00 25.04 ? 341 TRP A CZ2 1 ATOM 2649 C CZ3 . TRP A 1 324 ? 8.426 -13.820 -23.532 1.00 25.18 ? 341 TRP A CZ3 1 ATOM 2650 C CH2 . TRP A 1 324 ? 8.317 -12.648 -24.298 1.00 25.79 ? 341 TRP A CH2 1 ATOM 2651 N N . ASP A 1 325 ? 13.712 -16.476 -20.158 1.00 19.24 ? 342 ASP A N 1 ATOM 2652 C CA . ASP A 1 325 ? 13.985 -17.711 -19.426 1.00 19.18 ? 342 ASP A CA 1 ATOM 2653 C C . ASP A 1 325 ? 12.740 -18.567 -19.550 1.00 19.95 ? 342 ASP A C 1 ATOM 2654 O O . ASP A 1 325 ? 11.660 -18.133 -19.162 1.00 19.39 ? 342 ASP A O 1 ATOM 2655 C CB . ASP A 1 325 ? 14.242 -17.384 -17.950 1.00 18.69 ? 342 ASP A CB 1 ATOM 2656 C CG . ASP A 1 325 ? 14.775 -18.569 -17.159 1.00 18.72 ? 342 ASP A CG 1 ATOM 2657 O OD1 . ASP A 1 325 ? 14.763 -19.715 -17.673 1.00 18.43 ? 342 ASP A OD1 1 ATOM 2658 O OD2 . ASP A 1 325 ? 15.196 -18.343 -16.002 1.00 17.63 ? 342 ASP A OD2 1 ATOM 2659 N N . PHE A 1 326 ? 12.893 -19.782 -20.074 1.00 21.30 ? 343 PHE A N 1 ATOM 2660 C CA . PHE A 1 326 ? 11.752 -20.700 -20.234 1.00 21.43 ? 343 PHE A CA 1 ATOM 2661 C C . PHE A 1 326 ? 11.568 -21.699 -19.088 1.00 22.38 ? 343 PHE A C 1 ATOM 2662 O O . PHE A 1 326 ? 10.656 -22.538 -19.137 1.00 21.91 ? 343 PHE A O 1 ATOM 2663 C CB . PHE A 1 326 ? 11.826 -21.373 -21.605 1.00 21.71 ? 343 PHE A CB 1 ATOM 2664 C CG . PHE A 1 326 ? 11.463 -20.437 -22.709 1.00 21.41 ? 343 PHE A CG 1 ATOM 2665 C CD1 . PHE A 1 326 ? 12.387 -19.509 -23.177 1.00 22.03 ? 343 PHE A CD1 1 ATOM 2666 C CD2 . PHE A 1 326 ? 10.176 -20.420 -23.224 1.00 22.28 ? 343 PHE A CD2 1 ATOM 2667 C CE1 . PHE A 1 326 ? 12.043 -18.602 -24.166 1.00 21.85 ? 343 PHE A CE1 1 ATOM 2668 C CE2 . PHE A 1 326 ? 9.826 -19.517 -24.215 1.00 23.05 ? 343 PHE A CE2 1 ATOM 2669 C CZ . PHE A 1 326 ? 10.760 -18.599 -24.683 1.00 22.58 ? 343 PHE A CZ 1 ATOM 2670 N N . TYR A 1 327 ? 12.398 -21.575 -18.049 1.00 22.89 ? 344 TYR A N 1 ATOM 2671 C CA . TYR A 1 327 ? 12.195 -22.260 -16.754 1.00 24.28 ? 344 TYR A CA 1 ATOM 2672 C C . TYR A 1 327 ? 12.261 -23.784 -16.810 1.00 25.07 ? 344 TYR A C 1 ATOM 2673 O O . TYR A 1 327 ? 11.618 -24.474 -16.012 1.00 25.84 ? 344 TYR A O 1 ATOM 2674 C CB . TYR A 1 327 ? 10.892 -21.787 -16.086 1.00 24.87 ? 344 TYR A CB 1 ATOM 2675 C CG . TYR A 1 327 ? 10.926 -20.327 -15.729 1.00 26.20 ? 344 TYR A CG 1 ATOM 2676 C CD1 . TYR A 1 327 ? 11.749 -19.864 -14.698 1.00 27.89 ? 344 TYR A CD1 1 ATOM 2677 C CD2 . TYR A 1 327 ? 10.153 -19.401 -16.418 1.00 27.97 ? 344 TYR A CD2 1 ATOM 2678 C CE1 . TYR A 1 327 ? 11.794 -18.517 -14.363 1.00 28.52 ? 344 TYR A CE1 1 ATOM 2679 C CE2 . TYR A 1 327 ? 10.185 -18.053 -16.086 1.00 28.73 ? 344 TYR A CE2 1 ATOM 2680 C CZ . TYR A 1 327 ? 11.013 -17.618 -15.064 1.00 30.10 ? 344 TYR A CZ 1 ATOM 2681 O OH . TYR A 1 327 ? 11.048 -16.278 -14.736 1.00 34.20 ? 344 TYR A OH 1 ATOM 2682 N N . LEU A 1 328 ? 13.053 -24.295 -17.744 1.00 26.04 ? 345 LEU A N 1 ATOM 2683 C CA . LEU A 1 328 ? 13.395 -25.713 -17.814 1.00 26.92 ? 345 LEU A CA 1 ATOM 2684 C C . LEU A 1 328 ? 14.885 -25.785 -17.486 1.00 26.54 ? 345 LEU A C 1 ATOM 2685 O O . LEU A 1 328 ? 15.317 -25.156 -16.528 1.00 26.48 ? 345 LEU A O 1 ATOM 2686 C CB . LEU A 1 328 ? 13.069 -26.258 -19.205 1.00 27.75 ? 345 LEU A CB 1 ATOM 2687 C CG . LEU A 1 328 ? 11.656 -26.000 -19.725 1.00 28.45 ? 345 LEU A CG 1 ATOM 2688 C CD1 . LEU A 1 328 ? 11.522 -26.529 -21.154 1.00 30.60 ? 345 LEU A CD1 1 ATOM 2689 C CD2 . LEU A 1 328 ? 10.620 -26.619 -18.812 1.00 28.42 ? 345 LEU A CD2 1 ATOM 2690 N N . THR A 1 329 ? 15.662 -26.548 -18.253 1.00 26.28 ? 346 THR A N 1 ATOM 2691 C CA . THR A 1 329 ? 17.107 -26.519 -18.184 1.00 27.52 ? 346 THR A CA 1 ATOM 2692 C C . THR A 1 329 ? 17.588 -26.135 -19.571 1.00 26.44 ? 346 THR A C 1 ATOM 2693 O O . THR A 1 329 ? 17.216 -26.779 -20.550 1.00 25.40 ? 346 THR A O 1 ATOM 2694 C CB . THR A 1 329 ? 17.665 -27.899 -17.797 1.00 28.85 ? 346 THR A CB 1 ATOM 2695 O OG1 . THR A 1 329 ? 17.232 -28.216 -16.469 1.00 33.97 ? 346 THR A OG1 1 ATOM 2696 C CG2 . THR A 1 329 ? 19.195 -27.926 -17.852 1.00 28.87 ? 346 THR A CG2 1 ATOM 2697 N N . ASP A 1 330 ? 18.359 -25.052 -19.650 1.00 25.94 ? 347 ASP A N 1 ATOM 2698 C CA . ASP A 1 330 ? 19.027 -24.625 -20.885 1.00 25.58 ? 347 ASP A CA 1 ATOM 2699 C C . ASP A 1 330 ? 18.125 -24.068 -21.996 1.00 24.07 ? 347 ASP A C 1 ATOM 2700 O O . ASP A 1 330 ? 18.632 -23.775 -23.074 1.00 24.21 ? 347 ASP A O 1 ATOM 2701 C CB . ASP A 1 330 ? 19.953 -25.736 -21.439 1.00 26.14 ? 347 ASP A CB 1 ATOM 2702 C CG . ASP A 1 330 ? 21.189 -25.950 -20.585 1.00 27.77 ? 347 ASP A CG 1 ATOM 2703 O OD1 . ASP A 1 330 ? 21.482 -25.113 -19.712 1.00 28.65 ? 347 ASP A OD1 1 ATOM 2704 O OD2 . ASP A 1 330 ? 21.890 -26.957 -20.795 1.00 28.80 ? 347 ASP A OD2 1 ATOM 2705 N N . ASP A 1 331 ? 16.820 -23.909 -21.764 1.00 23.25 ? 348 ASP A N 1 ATOM 2706 C CA . ASP A 1 331 ? 15.967 -23.236 -22.755 1.00 23.04 ? 348 ASP A CA 1 ATOM 2707 C C . ASP A 1 331 ? 15.907 -21.758 -22.394 1.00 21.66 ? 348 ASP A C 1 ATOM 2708 O O . ASP A 1 331 ? 15.105 -21.325 -21.566 1.00 20.13 ? 348 ASP A O 1 ATOM 2709 C CB . ASP A 1 331 ? 14.565 -23.825 -22.866 1.00 23.92 ? 348 ASP A CB 1 ATOM 2710 C CG . ASP A 1 331 ? 13.777 -23.242 -24.054 1.00 24.89 ? 348 ASP A CG 1 ATOM 2711 O OD1 . ASP A 1 331 ? 14.254 -22.298 -24.733 1.00 26.04 ? 348 ASP A OD1 1 ATOM 2712 O OD2 . ASP A 1 331 ? 12.668 -23.732 -24.324 1.00 25.55 ? 348 ASP A OD2 1 ATOM 2713 N N . VAL A 1 332 ? 16.798 -21.009 -23.029 1.00 21.04 ? 349 VAL A N 1 ATOM 2714 C CA . VAL A 1 332 ? 16.924 -19.569 -22.832 1.00 20.58 ? 349 VAL A CA 1 ATOM 2715 C C . VAL A 1 332 ? 17.086 -18.954 -24.218 1.00 20.96 ? 349 VAL A C 1 ATOM 2716 O O . VAL A 1 332 ? 17.718 -19.558 -25.075 1.00 21.51 ? 349 VAL A O 1 ATOM 2717 C CB . VAL A 1 332 ? 18.115 -19.226 -21.906 1.00 20.10 ? 349 VAL A CB 1 ATOM 2718 C CG1 . VAL A 1 332 ? 17.838 -19.719 -20.494 1.00 20.27 ? 349 VAL A CG1 1 ATOM 2719 C CG2 . VAL A 1 332 ? 19.429 -19.812 -22.415 1.00 20.24 ? 349 VAL A CG2 1 ATOM 2720 N N . ARG A 1 333 ? 16.484 -17.788 -24.443 1.00 20.63 ? 350 ARG A N 1 ATOM 2721 C CA . ARG A 1 333 ? 16.437 -17.176 -25.781 1.00 21.44 ? 350 ARG A CA 1 ATOM 2722 C C . ARG A 1 333 ? 16.507 -15.664 -25.718 1.00 20.30 ? 350 ARG A C 1 ATOM 2723 O O . ARG A 1 333 ? 16.047 -15.050 -24.761 1.00 19.67 ? 350 ARG A O 1 ATOM 2724 C CB . ARG A 1 333 ? 15.124 -17.516 -26.496 1.00 22.29 ? 350 ARG A CB 1 ATOM 2725 C CG . ARG A 1 333 ? 14.814 -18.986 -26.581 1.00 23.74 ? 350 ARG A CG 1 ATOM 2726 C CD . ARG A 1 333 ? 13.448 -19.231 -27.168 1.00 25.04 ? 350 ARG A CD 1 ATOM 2727 N NE . ARG A 1 333 ? 12.920 -20.510 -26.693 1.00 26.11 ? 350 ARG A NE 1 ATOM 2728 C CZ . ARG A 1 333 ? 11.700 -20.957 -26.955 1.00 27.49 ? 350 ARG A CZ 1 ATOM 2729 N NH1 . ARG A 1 333 ? 10.869 -20.249 -27.712 1.00 28.96 ? 350 ARG A NH1 1 ATOM 2730 N NH2 . ARG A 1 333 ? 11.310 -22.127 -26.467 1.00 27.63 ? 350 ARG A NH2 1 ATOM 2731 N N . ILE A 1 334 ? 17.044 -15.075 -26.777 1.00 20.21 ? 351 ILE A N 1 ATOM 2732 C CA . ILE A 1 334 ? 16.965 -13.637 -26.978 1.00 20.02 ? 351 ILE A CA 1 ATOM 2733 C C . ILE A 1 334 ? 16.117 -13.362 -28.211 1.00 19.84 ? 351 ILE A C 1 ATOM 2734 O O . ILE A 1 334 ? 16.163 -14.108 -29.189 1.00 19.16 ? 351 ILE A O 1 ATOM 2735 C CB . ILE A 1 334 ? 18.384 -13.020 -27.077 1.00 20.14 ? 351 ILE A CB 1 ATOM 2736 C CG1 . ILE A 1 334 ? 18.955 -12.872 -25.666 1.00 19.99 ? 351 ILE A CG1 1 ATOM 2737 C CG2 . ILE A 1 334 ? 18.380 -11.659 -27.774 1.00 20.00 ? 351 ILE A CG2 1 ATOM 2738 C CD1 . ILE A 1 334 ? 20.451 -12.653 -25.605 1.00 20.09 ? 351 ILE A CD1 1 ATOM 2739 N N . LYS A 1 335 ? 15.333 -12.290 -28.141 1.00 20.57 ? 352 LYS A N 1 ATOM 2740 C CA . LYS A 1 335 ? 14.705 -11.701 -29.317 1.00 21.10 ? 352 LYS A CA 1 ATOM 2741 C C . LYS A 1 335 ? 15.277 -10.303 -29.484 1.00 20.58 ? 352 LYS A C 1 ATOM 2742 O O . LYS A 1 335 ? 15.062 -9.449 -28.625 1.00 20.41 ? 352 LYS A O 1 ATOM 2743 C CB . LYS A 1 335 ? 13.192 -11.651 -29.165 1.00 22.49 ? 352 LYS A CB 1 ATOM 2744 C CG . LYS A 1 335 ? 12.472 -11.028 -30.356 1.00 23.71 ? 352 LYS A CG 1 ATOM 2745 C CD . LYS A 1 335 ? 11.016 -11.491 -30.439 1.00 25.25 ? 352 LYS A CD 1 ATOM 2746 C CE . LYS A 1 335 ? 10.205 -11.153 -29.197 1.00 25.40 ? 352 LYS A CE 1 ATOM 2747 N NZ . LYS A 1 335 ? 10.069 -9.684 -29.008 1.00 25.91 ? 352 LYS A NZ 1 ATOM 2748 N N . GLN A 1 336 ? 16.027 -10.084 -30.567 1.00 19.44 ? 353 GLN A N 1 ATOM 2749 C CA . GLN A 1 336 ? 16.604 -8.768 -30.866 1.00 19.25 ? 353 GLN A CA 1 ATOM 2750 C C . GLN A 1 336 ? 16.597 -8.512 -32.363 1.00 19.68 ? 353 GLN A C 1 ATOM 2751 O O . GLN A 1 336 ? 17.030 -9.359 -33.138 1.00 18.88 ? 353 GLN A O 1 ATOM 2752 C CB . GLN A 1 336 ? 18.037 -8.656 -30.314 1.00 18.91 ? 353 GLN A CB 1 ATOM 2753 C CG . GLN A 1 336 ? 18.654 -7.262 -30.434 1.00 19.36 ? 353 GLN A CG 1 ATOM 2754 C CD . GLN A 1 336 ? 20.014 -7.122 -29.751 1.00 19.53 ? 353 GLN A CD 1 ATOM 2755 O OE1 . GLN A 1 336 ? 20.310 -7.815 -28.779 1.00 20.24 ? 353 GLN A OE1 1 ATOM 2756 N NE2 . GLN A 1 336 ? 20.827 -6.187 -30.233 1.00 19.59 ? 353 GLN A NE2 1 ATOM 2757 N N . CYS A 1 337 ? 16.123 -7.326 -32.756 1.00 19.38 ? 354 CYS A N 1 ATOM 2758 C CA . CYS A 1 337 ? 16.141 -6.906 -34.151 1.00 20.32 ? 354 CYS A CA 1 ATOM 2759 C C . CYS A 1 337 ? 17.508 -6.273 -34.432 1.00 19.90 ? 354 CYS A C 1 ATOM 2760 O O . CYS A 1 337 ? 17.633 -5.070 -34.646 1.00 19.59 ? 354 CYS A O 1 ATOM 2761 C CB . CYS A 1 337 ? 14.971 -5.964 -34.413 1.00 21.21 ? 354 CYS A CB 1 ATOM 2762 S SG . CYS A 1 337 ? 13.414 -6.837 -34.118 1.00 21.96 ? 354 CYS A SG 1 ATOM 2763 N N . THR A 1 338 ? 18.524 -7.128 -34.431 1.00 19.68 ? 355 THR A N 1 ATOM 2764 C CA . THR A 1 338 ? 19.915 -6.706 -34.322 1.00 20.13 ? 355 THR A CA 1 ATOM 2765 C C . THR A 1 338 ? 20.388 -6.004 -35.580 1.00 20.35 ? 355 THR A C 1 ATOM 2766 O O . THR A 1 338 ? 20.118 -6.465 -36.678 1.00 20.22 ? 355 THR A O 1 ATOM 2767 C CB . THR A 1 338 ? 20.852 -7.903 -34.068 1.00 20.51 ? 355 THR A CB 1 ATOM 2768 O OG1 . THR A 1 338 ? 20.299 -8.736 -33.037 1.00 20.14 ? 355 THR A OG1 1 ATOM 2769 C CG2 . THR A 1 338 ? 22.266 -7.447 -33.668 1.00 21.11 ? 355 THR A CG2 1 ATOM 2770 N N . ARG A 1 339 ? 21.092 -4.894 -35.402 1.00 21.11 ? 356 ARG A N 1 ATOM 2771 C CA . ARG A 1 339 ? 21.803 -4.232 -36.493 1.00 22.35 ? 356 ARG A CA 1 ATOM 2772 C C . ARG A 1 339 ? 23.285 -4.206 -36.133 1.00 21.71 ? 356 ARG A C 1 ATOM 2773 O O . ARG A 1 339 ? 23.650 -4.315 -34.963 1.00 19.99 ? 356 ARG A O 1 ATOM 2774 C CB . ARG A 1 339 ? 21.252 -2.817 -36.711 1.00 24.20 ? 356 ARG A CB 1 ATOM 2775 C CG . ARG A 1 339 ? 19.817 -2.812 -37.238 1.00 27.54 ? 356 ARG A CG 1 ATOM 2776 C CD . ARG A 1 339 ? 19.119 -1.463 -37.080 1.00 30.32 ? 356 ARG A CD 1 ATOM 2777 N NE . ARG A 1 339 ? 18.823 -1.184 -35.675 1.00 35.37 ? 356 ARG A NE 1 ATOM 2778 C CZ . ARG A 1 339 ? 19.561 -0.441 -34.840 1.00 38.16 ? 356 ARG A CZ 1 ATOM 2779 N NH1 . ARG A 1 339 ? 20.675 0.174 -35.234 1.00 38.99 ? 356 ARG A NH1 1 ATOM 2780 N NH2 . ARG A 1 339 ? 19.166 -0.306 -33.574 1.00 41.84 ? 356 ARG A NH2 1 ATOM 2781 N N . VAL A 1 340 ? 24.124 -4.068 -37.148 1.00 20.85 ? 357 VAL A N 1 ATOM 2782 C CA . VAL A 1 340 ? 25.573 -4.121 -36.992 1.00 20.90 ? 357 VAL A CA 1 ATOM 2783 C C . VAL A 1 340 ? 26.096 -2.716 -36.653 1.00 21.28 ? 357 VAL A C 1 ATOM 2784 O O . VAL A 1 340 ? 26.547 -1.963 -37.516 1.00 21.52 ? 357 VAL A O 1 ATOM 2785 C CB . VAL A 1 340 ? 26.239 -4.726 -38.257 1.00 20.70 ? 357 VAL A CB 1 ATOM 2786 C CG1 . VAL A 1 340 ? 27.746 -4.892 -38.079 1.00 20.93 ? 357 VAL A CG1 1 ATOM 2787 C CG2 . VAL A 1 340 ? 25.608 -6.073 -38.593 1.00 21.29 ? 357 VAL A CG2 1 ATOM 2788 N N . THR A 1 341 ? 25.997 -2.360 -35.376 1.00 20.97 ? 358 THR A N 1 ATOM 2789 C CA . THR A 1 341 ? 26.491 -1.080 -34.874 1.00 21.49 ? 358 THR A CA 1 ATOM 2790 C C . THR A 1 341 ? 27.153 -1.276 -33.519 1.00 21.86 ? 358 THR A C 1 ATOM 2791 O O . THR A 1 341 ? 26.928 -2.284 -32.850 1.00 22.42 ? 358 THR A O 1 ATOM 2792 C CB . THR A 1 341 ? 25.377 -0.040 -34.713 1.00 20.96 ? 358 THR A CB 1 ATOM 2793 O OG1 . THR A 1 341 ? 24.490 -0.436 -33.650 1.00 20.39 ? 358 THR A OG1 1 ATOM 2794 C CG2 . THR A 1 341 ? 24.586 0.140 -36.016 1.00 20.77 ? 358 THR A CG2 1 ATOM 2795 N N . GLN A 1 342 ? 27.949 -0.288 -33.127 1.00 22.71 ? 359 GLN A N 1 ATOM 2796 C CA . GLN A 1 342 ? 28.592 -0.264 -31.825 1.00 23.85 ? 359 GLN A CA 1 ATOM 2797 C C . GLN A 1 342 ? 27.558 -0.321 -30.708 1.00 24.43 ? 359 GLN A C 1 ATOM 2798 O O . GLN A 1 342 ? 27.718 -1.074 -29.749 1.00 23.62 ? 359 GLN A O 1 ATOM 2799 C CB . GLN A 1 342 ? 29.419 1.008 -31.674 1.00 24.34 ? 359 GLN A CB 1 ATOM 2800 C CG . GLN A 1 342 ? 30.115 1.144 -30.326 1.00 25.34 ? 359 GLN A CG 1 ATOM 2801 C CD . GLN A 1 342 ? 31.212 2.186 -30.344 1.00 26.55 ? 359 GLN A CD 1 ATOM 2802 O OE1 . GLN A 1 342 ? 32.176 2.062 -31.082 1.00 26.83 ? 359 GLN A OE1 1 ATOM 2803 N NE2 . GLN A 1 342 ? 31.060 3.228 -29.542 1.00 28.96 ? 359 GLN A NE2 1 ATOM 2804 N N . ASP A 1 343 ? 26.509 0.485 -30.841 1.00 24.79 ? 360 ASP A N 1 ATOM 2805 C CA . ASP A 1 343 ? 25.438 0.533 -29.836 1.00 26.71 ? 360 ASP A CA 1 ATOM 2806 C C . ASP A 1 343 ? 24.766 -0.825 -29.682 1.00 24.70 ? 360 ASP A C 1 ATOM 2807 O O . ASP A 1 343 ? 24.498 -1.275 -28.570 1.00 23.09 ? 360 ASP A O 1 ATOM 2808 C CB . ASP A 1 343 ? 24.374 1.560 -30.212 1.00 30.83 ? 360 ASP A CB 1 ATOM 2809 C CG . ASP A 1 343 ? 24.166 2.570 -29.140 1.00 37.12 ? 360 ASP A CG 1 ATOM 2810 O OD1 . ASP A 1 343 ? 24.947 3.552 -29.121 1.00 41.82 ? 360 ASP A OD1 1 ATOM 2811 O OD2 . ASP A 1 343 ? 23.231 2.381 -28.328 1.00 41.43 ? 360 ASP A OD2 1 ATOM 2812 N N . GLN A 1 344 ? 24.498 -1.462 -30.816 1.00 23.23 ? 361 GLN A N 1 ATOM 2813 C CA . GLN A 1 344 ? 23.854 -2.773 -30.826 1.00 23.34 ? 361 GLN A CA 1 ATOM 2814 C C . GLN A 1 344 ? 24.747 -3.854 -30.222 1.00 22.76 ? 361 GLN A C 1 ATOM 2815 O O . GLN A 1 344 ? 24.247 -4.753 -29.554 1.00 22.73 ? 361 GLN A O 1 ATOM 2816 C CB . GLN A 1 344 ? 23.443 -3.146 -32.239 1.00 23.68 ? 361 GLN A CB 1 ATOM 2817 C CG . GLN A 1 344 ? 22.223 -2.392 -32.720 1.00 24.58 ? 361 GLN A CG 1 ATOM 2818 C CD . GLN A 1 344 ? 20.941 -3.012 -32.194 1.00 26.46 ? 361 GLN A CD 1 ATOM 2819 O OE1 . GLN A 1 344 ? 20.607 -4.134 -32.543 1.00 24.51 ? 361 GLN A OE1 1 ATOM 2820 N NE2 . GLN A 1 344 ? 20.238 -2.294 -31.325 1.00 29.86 ? 361 GLN A NE2 1 ATOM 2821 N N . LEU A 1 345 ? 26.057 -3.753 -30.435 1.00 21.84 ? 362 LEU A N 1 ATOM 2822 C CA . LEU A 1 345 ? 27.005 -4.664 -29.784 1.00 22.32 ? 362 LEU A CA 1 ATOM 2823 C C . LEU A 1 345 ? 26.890 -4.582 -28.256 1.00 22.04 ? 362 LEU A C 1 ATOM 2824 O O . LEU A 1 345 ? 26.909 -5.617 -27.584 1.00 21.73 ? 362 LEU A O 1 ATOM 2825 C CB . LEU A 1 345 ? 28.440 -4.376 -30.223 1.00 22.78 ? 362 LEU A CB 1 ATOM 2826 C CG . LEU A 1 345 ? 29.530 -5.352 -29.773 1.00 23.21 ? 362 LEU A CG 1 ATOM 2827 C CD1 . LEU A 1 345 ? 29.322 -6.752 -30.318 1.00 23.70 ? 362 LEU A CD1 1 ATOM 2828 C CD2 . LEU A 1 345 ? 30.895 -4.818 -30.180 1.00 23.81 ? 362 LEU A CD2 1 ATOM 2829 N N . PHE A 1 346 ? 26.734 -3.370 -27.716 1.00 22.12 ? 363 PHE A N 1 ATOM 2830 C CA . PHE A 1 346 ? 26.509 -3.223 -26.271 1.00 22.79 ? 363 PHE A CA 1 ATOM 2831 C C . PHE A 1 346 ? 25.181 -3.871 -25.852 1.00 21.76 ? 363 PHE A C 1 ATOM 2832 O O . PHE A 1 346 ? 25.131 -4.582 -24.845 1.00 22.36 ? 363 PHE A O 1 ATOM 2833 C CB . PHE A 1 346 ? 26.572 -1.749 -25.815 1.00 23.20 ? 363 PHE A CB 1 ATOM 2834 C CG . PHE A 1 346 ? 27.880 -1.048 -26.126 1.00 24.27 ? 363 PHE A CG 1 ATOM 2835 C CD1 . PHE A 1 346 ? 29.098 -1.733 -26.146 1.00 25.94 ? 363 PHE A CD1 1 ATOM 2836 C CD2 . PHE A 1 346 ? 27.892 0.322 -26.370 1.00 25.75 ? 363 PHE A CD2 1 ATOM 2837 C CE1 . PHE A 1 346 ? 30.286 -1.072 -26.427 1.00 26.45 ? 363 PHE A CE1 1 ATOM 2838 C CE2 . PHE A 1 346 ? 29.081 0.995 -26.651 1.00 25.67 ? 363 PHE A CE2 1 ATOM 2839 C CZ . PHE A 1 346 ? 30.278 0.300 -26.675 1.00 25.93 ? 363 PHE A CZ 1 ATOM 2840 N N . THR A 1 347 ? 24.120 -3.653 -26.633 1.00 20.64 ? 364 THR A N 1 ATOM 2841 C CA . THR A 1 347 ? 22.811 -4.253 -26.348 1.00 19.58 ? 364 THR A CA 1 ATOM 2842 C C . THR A 1 347 ? 22.898 -5.774 -26.331 1.00 18.88 ? 364 THR A C 1 ATOM 2843 O O . THR A 1 347 ? 22.299 -6.411 -25.478 1.00 18.56 ? 364 THR A O 1 ATOM 2844 C CB . THR A 1 347 ? 21.735 -3.815 -27.368 1.00 19.40 ? 364 THR A CB 1 ATOM 2845 O OG1 . THR A 1 347 ? 21.557 -2.398 -27.278 1.00 19.85 ? 364 THR A OG1 1 ATOM 2846 C CG2 . THR A 1 347 ? 20.408 -4.492 -27.100 1.00 19.37 ? 364 THR A CG2 1 ATOM 2847 N N . VAL A 1 348 ? 23.642 -6.344 -27.271 1.00 18.32 ? 365 VAL A N 1 ATOM 2848 C CA . VAL A 1 348 ? 23.861 -7.801 -27.316 1.00 18.74 ? 365 VAL A CA 1 ATOM 2849 C C . VAL A 1 348 ? 24.402 -8.305 -25.984 1.00 18.85 ? 365 VAL A C 1 ATOM 2850 O O . VAL A 1 348 ? 23.886 -9.290 -25.433 1.00 19.45 ? 365 VAL A O 1 ATOM 2851 C CB . VAL A 1 348 ? 24.804 -8.201 -28.484 1.00 18.43 ? 365 VAL A CB 1 ATOM 2852 C CG1 . VAL A 1 348 ? 25.343 -9.621 -28.331 1.00 19.30 ? 365 VAL A CG1 1 ATOM 2853 C CG2 . VAL A 1 348 ? 24.070 -8.076 -29.805 1.00 17.97 ? 365 VAL A CG2 1 ATOM 2854 N N . HIS A 1 349 ? 25.430 -7.628 -25.477 1.00 18.37 ? 366 HIS A N 1 ATOM 2855 C CA . HIS A 1 349 ? 26.033 -8.001 -24.195 1.00 18.32 ? 366 HIS A CA 1 ATOM 2856 C C . HIS A 1 349 ? 25.065 -7.803 -23.047 1.00 17.93 ? 366 HIS A C 1 ATOM 2857 O O . HIS A 1 349 ? 24.977 -8.652 -22.154 1.00 17.64 ? 366 HIS A O 1 ATOM 2858 C CB . HIS A 1 349 ? 27.333 -7.245 -23.953 1.00 19.13 ? 366 HIS A CB 1 ATOM 2859 C CG . HIS A 1 349 ? 28.458 -7.726 -24.809 1.00 19.66 ? 366 HIS A CG 1 ATOM 2860 N ND1 . HIS A 1 349 ? 28.609 -7.337 -26.120 1.00 20.22 ? 366 HIS A ND1 1 ATOM 2861 C CD2 . HIS A 1 349 ? 29.470 -8.585 -24.553 1.00 19.82 ? 366 HIS A CD2 1 ATOM 2862 C CE1 . HIS A 1 349 ? 29.676 -7.926 -26.633 1.00 20.52 ? 366 HIS A CE1 1 ATOM 2863 N NE2 . HIS A 1 349 ? 30.213 -8.693 -25.703 1.00 20.84 ? 366 HIS A NE2 1 ATOM 2864 N N . HIS A 1 350 ? 24.318 -6.704 -23.084 1.00 17.73 ? 367 HIS A N 1 ATOM 2865 C CA . HIS A 1 350 ? 23.273 -6.470 -22.099 1.00 17.86 ? 367 HIS A CA 1 ATOM 2866 C C . HIS A 1 350 ? 22.302 -7.664 -22.015 1.00 17.79 ? 367 HIS A C 1 ATOM 2867 O O . HIS A 1 350 ? 22.058 -8.209 -20.940 1.00 17.93 ? 367 HIS A O 1 ATOM 2868 C CB . HIS A 1 350 ? 22.507 -5.199 -22.435 1.00 18.19 ? 367 HIS A CB 1 ATOM 2869 C CG . HIS A 1 350 ? 21.352 -4.964 -21.530 1.00 18.43 ? 367 HIS A CG 1 ATOM 2870 N ND1 . HIS A 1 350 ? 21.479 -4.312 -20.328 1.00 18.79 ? 367 HIS A ND1 1 ATOM 2871 C CD2 . HIS A 1 350 ? 20.060 -5.350 -21.620 1.00 18.50 ? 367 HIS A CD2 1 ATOM 2872 C CE1 . HIS A 1 350 ? 20.304 -4.282 -19.724 1.00 19.33 ? 367 HIS A CE1 1 ATOM 2873 N NE2 . HIS A 1 350 ? 19.435 -4.924 -20.480 1.00 18.93 ? 367 HIS A NE2 1 ATOM 2874 N N . GLU A 1 351 ? 21.770 -8.072 -23.160 1.00 17.99 ? 368 GLU A N 1 ATOM 2875 C CA . GLU A 1 351 ? 20.813 -9.174 -23.215 1.00 18.25 ? 368 GLU A CA 1 ATOM 2876 C C . GLU A 1 351 ? 21.462 -10.502 -22.822 1.00 18.76 ? 368 GLU A C 1 ATOM 2877 O O . GLU A 1 351 ? 20.838 -11.317 -22.149 1.00 18.80 ? 368 GLU A O 1 ATOM 2878 C CB . GLU A 1 351 ? 20.187 -9.284 -24.614 1.00 19.09 ? 368 GLU A CB 1 ATOM 2879 C CG . GLU A 1 351 ? 19.425 -8.054 -25.099 1.00 19.05 ? 368 GLU A CG 1 ATOM 2880 C CD . GLU A 1 351 ? 18.318 -7.612 -24.160 1.00 20.28 ? 368 GLU A CD 1 ATOM 2881 O OE1 . GLU A 1 351 ? 17.748 -8.460 -23.443 1.00 21.37 ? 368 GLU A OE1 1 ATOM 2882 O OE2 . GLU A 1 351 ? 18.028 -6.402 -24.135 1.00 20.72 ? 368 GLU A OE2 1 ATOM 2883 N N . LEU A 1 352 ? 22.713 -10.714 -23.222 1.00 17.76 ? 369 LEU A N 1 ATOM 2884 C CA . LEU A 1 352 ? 23.432 -11.935 -22.830 1.00 18.33 ? 369 LEU A CA 1 ATOM 2885 C C . LEU A 1 352 ? 23.729 -12.015 -21.328 1.00 18.58 ? 369 LEU A C 1 ATOM 2886 O O . LEU A 1 352 ? 23.888 -13.109 -20.783 1.00 18.73 ? 369 LEU A O 1 ATOM 2887 C CB . LEU A 1 352 ? 24.713 -12.103 -23.648 1.00 18.19 ? 369 LEU A CB 1 ATOM 2888 C CG . LEU A 1 352 ? 24.518 -12.536 -25.107 1.00 18.99 ? 369 LEU A CG 1 ATOM 2889 C CD1 . LEU A 1 352 ? 25.840 -12.497 -25.841 1.00 19.17 ? 369 LEU A CD1 1 ATOM 2890 C CD2 . LEU A 1 352 ? 23.925 -13.931 -25.209 1.00 18.65 ? 369 LEU A CD2 1 ATOM 2891 N N . GLY A 1 353 ? 23.827 -10.867 -20.662 1.00 18.50 ? 370 GLY A N 1 ATOM 2892 C CA . GLY A 1 353 ? 23.925 -10.834 -19.206 1.00 18.38 ? 370 GLY A CA 1 ATOM 2893 C C . GLY A 1 353 ? 22.698 -11.412 -18.521 1.00 18.32 ? 370 GLY A C 1 ATOM 2894 O O . GLY A 1 353 ? 22.822 -12.109 -17.504 1.00 18.14 ? 370 GLY A O 1 ATOM 2895 N N . HIS A 1 354 ? 21.517 -11.125 -19.069 1.00 17.62 ? 371 HIS A N 1 ATOM 2896 C CA . HIS A 1 354 ? 20.268 -11.720 -18.577 1.00 17.86 ? 371 HIS A CA 1 ATOM 2897 C C . HIS A 1 354 ? 20.338 -13.231 -18.745 1.00 17.33 ? 371 HIS A C 1 ATOM 2898 O O . HIS A 1 354 ? 20.051 -13.971 -17.813 1.00 15.70 ? 371 HIS A O 1 ATOM 2899 C CB . HIS A 1 354 ? 19.045 -11.214 -19.332 1.00 18.36 ? 371 HIS A CB 1 ATOM 2900 C CG . HIS A 1 354 ? 18.688 -9.787 -19.059 1.00 18.61 ? 371 HIS A CG 1 ATOM 2901 N ND1 . HIS A 1 354 ? 18.467 -9.301 -17.792 1.00 18.95 ? 371 HIS A ND1 1 ATOM 2902 C CD2 . HIS A 1 354 ? 18.437 -8.757 -19.898 1.00 19.18 ? 371 HIS A CD2 1 ATOM 2903 C CE1 . HIS A 1 354 ? 18.124 -8.030 -17.852 1.00 18.91 ? 371 HIS A CE1 1 ATOM 2904 N NE2 . HIS A 1 354 ? 18.093 -7.679 -19.122 1.00 18.62 ? 371 HIS A NE2 1 ATOM 2905 N N . ILE A 1 355 ? 20.770 -13.668 -19.927 1.00 17.81 ? 372 ILE A N 1 ATOM 2906 C CA . ILE A 1 355 ? 20.870 -15.101 -20.237 1.00 17.98 ? 372 ILE A CA 1 ATOM 2907 C C . ILE A 1 355 ? 21.833 -15.795 -19.275 1.00 18.20 ? 372 ILE A C 1 ATOM 2908 O O . ILE A 1 355 ? 21.491 -16.848 -18.704 1.00 18.06 ? 372 ILE A O 1 ATOM 2909 C CB . ILE A 1 355 ? 21.308 -15.338 -21.703 1.00 18.42 ? 372 ILE A CB 1 ATOM 2910 C CG1 . ILE A 1 355 ? 20.250 -14.808 -22.685 1.00 18.50 ? 372 ILE A CG1 1 ATOM 2911 C CG2 . ILE A 1 355 ? 21.617 -16.810 -21.963 1.00 18.34 ? 372 ILE A CG2 1 ATOM 2912 C CD1 . ILE A 1 355 ? 18.889 -15.477 -22.626 1.00 18.75 ? 372 ILE A CD1 1 ATOM 2913 N N . GLN A 1 356 ? 23.012 -15.203 -19.072 1.00 18.07 ? 373 GLN A N 1 ATOM 2914 C CA . GLN A 1 356 ? 23.992 -15.759 -18.133 1.00 18.46 ? 373 GLN A CA 1 ATOM 2915 C C . GLN A 1 356 ? 23.364 -15.962 -16.752 1.00 18.58 ? 373 GLN A C 1 ATOM 2916 O O . GLN A 1 356 ? 23.521 -17.022 -16.136 1.00 19.32 ? 373 GLN A O 1 ATOM 2917 C CB . GLN A 1 356 ? 25.235 -14.866 -18.022 1.00 19.07 ? 373 GLN A CB 1 ATOM 2918 C CG . GLN A 1 356 ? 26.409 -15.475 -17.235 1.00 19.58 ? 373 GLN A CG 1 ATOM 2919 C CD . GLN A 1 356 ? 26.896 -16.816 -17.774 1.00 20.47 ? 373 GLN A CD 1 ATOM 2920 O OE1 . GLN A 1 356 ? 27.328 -17.681 -17.008 1.00 21.10 ? 373 GLN A OE1 1 ATOM 2921 N NE2 . GLN A 1 356 ? 26.836 -16.997 -19.089 1.00 20.85 ? 373 GLN A NE2 1 ATOM 2922 N N . TYR A 1 357 ? 22.640 -14.947 -16.288 1.00 17.78 ? 374 TYR A N 1 ATOM 2923 C CA . TYR A 1 357 ? 21.979 -14.994 -14.995 1.00 17.85 ? 374 TYR A CA 1 ATOM 2924 C C . TYR A 1 357 ? 20.987 -16.178 -14.942 1.00 18.17 ? 374 TYR A C 1 ATOM 2925 O O . TYR A 1 357 ? 21.001 -16.960 -13.982 1.00 18.19 ? 374 TYR A O 1 ATOM 2926 C CB . TYR A 1 357 ? 21.266 -13.664 -14.717 1.00 17.53 ? 374 TYR A CB 1 ATOM 2927 C CG . TYR A 1 357 ? 21.245 -13.166 -13.287 1.00 17.09 ? 374 TYR A CG 1 ATOM 2928 C CD1 . TYR A 1 357 ? 21.378 -14.023 -12.188 1.00 16.67 ? 374 TYR A CD1 1 ATOM 2929 C CD2 . TYR A 1 357 ? 21.037 -11.811 -13.034 1.00 16.52 ? 374 TYR A CD2 1 ATOM 2930 C CE1 . TYR A 1 357 ? 21.333 -13.529 -10.896 1.00 16.28 ? 374 TYR A CE1 1 ATOM 2931 C CE2 . TYR A 1 357 ? 20.983 -11.316 -11.752 1.00 16.02 ? 374 TYR A CE2 1 ATOM 2932 C CZ . TYR A 1 357 ? 21.146 -12.176 -10.681 1.00 15.66 ? 374 TYR A CZ 1 ATOM 2933 O OH . TYR A 1 357 ? 21.085 -11.681 -9.406 1.00 15.44 ? 374 TYR A OH 1 ATOM 2934 N N . PHE A 1 358 ? 20.161 -16.333 -15.987 1.00 18.58 ? 375 PHE A N 1 ATOM 2935 C CA . PHE A 1 358 ? 19.216 -17.460 -16.063 1.00 18.60 ? 375 PHE A CA 1 ATOM 2936 C C . PHE A 1 358 ? 19.934 -18.794 -15.893 1.00 19.81 ? 375 PHE A C 1 ATOM 2937 O O . PHE A 1 358 ? 19.479 -19.664 -15.154 1.00 20.18 ? 375 PHE A O 1 ATOM 2938 C CB . PHE A 1 358 ? 18.449 -17.532 -17.403 1.00 18.72 ? 375 PHE A CB 1 ATOM 2939 C CG . PHE A 1 358 ? 17.664 -16.289 -17.774 1.00 17.83 ? 375 PHE A CG 1 ATOM 2940 C CD1 . PHE A 1 358 ? 17.112 -15.445 -16.814 1.00 17.40 ? 375 PHE A CD1 1 ATOM 2941 C CD2 . PHE A 1 358 ? 17.434 -15.998 -19.115 1.00 17.61 ? 375 PHE A CD2 1 ATOM 2942 C CE1 . PHE A 1 358 ? 16.377 -14.329 -17.179 1.00 17.62 ? 375 PHE A CE1 1 ATOM 2943 C CE2 . PHE A 1 358 ? 16.701 -14.882 -19.485 1.00 17.37 ? 375 PHE A CE2 1 ATOM 2944 C CZ . PHE A 1 358 ? 16.166 -14.047 -18.519 1.00 17.39 ? 375 PHE A CZ 1 ATOM 2945 N N . LEU A 1 359 ? 21.045 -18.954 -16.600 1.00 20.26 ? 376 LEU A N 1 ATOM 2946 C CA . LEU A 1 359 ? 21.793 -20.204 -16.575 1.00 20.49 ? 376 LEU A CA 1 ATOM 2947 C C . LEU A 1 359 ? 22.416 -20.448 -15.201 1.00 20.12 ? 376 LEU A C 1 ATOM 2948 O O . LEU A 1 359 ? 22.351 -21.566 -14.677 1.00 19.95 ? 376 LEU A O 1 ATOM 2949 C CB . LEU A 1 359 ? 22.860 -20.214 -17.667 1.00 20.33 ? 376 LEU A CB 1 ATOM 2950 C CG . LEU A 1 359 ? 22.327 -20.179 -19.113 1.00 20.31 ? 376 LEU A CG 1 ATOM 2951 C CD1 . LEU A 1 359 ? 23.454 -19.890 -20.097 1.00 20.42 ? 376 LEU A CD1 1 ATOM 2952 C CD2 . LEU A 1 359 ? 21.604 -21.476 -19.473 1.00 20.68 ? 376 LEU A CD2 1 ATOM 2953 N N . GLN A 1 360 ? 22.979 -19.398 -14.616 1.00 19.75 ? 377 GLN A N 1 ATOM 2954 C CA . GLN A 1 360 ? 23.626 -19.483 -13.300 1.00 19.72 ? 377 GLN A CA 1 ATOM 2955 C C . GLN A 1 360 ? 22.698 -19.932 -12.163 1.00 19.63 ? 377 GLN A C 1 ATOM 2956 O O . GLN A 1 360 ? 23.118 -20.654 -11.269 1.00 20.09 ? 377 GLN A O 1 ATOM 2957 C CB . GLN A 1 360 ? 24.261 -18.141 -12.946 1.00 19.49 ? 377 GLN A CB 1 ATOM 2958 C CG . GLN A 1 360 ? 25.526 -17.835 -13.729 1.00 19.62 ? 377 GLN A CG 1 ATOM 2959 C CD . GLN A 1 360 ? 26.712 -18.675 -13.303 1.00 20.39 ? 377 GLN A CD 1 ATOM 2960 O OE1 . GLN A 1 360 ? 26.859 -19.019 -12.127 1.00 20.58 ? 377 GLN A OE1 1 ATOM 2961 N NE2 . GLN A 1 360 ? 27.578 -19.000 -14.258 1.00 20.94 ? 377 GLN A NE2 1 ATOM 2962 N N . TYR A 1 361 ? 21.439 -19.523 -12.204 1.00 18.92 ? 378 TYR A N 1 ATOM 2963 C CA . TYR A 1 361 ? 20.513 -19.863 -11.141 1.00 18.86 ? 378 TYR A CA 1 ATOM 2964 C C . TYR A 1 361 ? 19.476 -20.913 -11.517 1.00 19.33 ? 378 TYR A C 1 ATOM 2965 O O . TYR A 1 361 ? 18.539 -21.133 -10.755 1.00 19.68 ? 378 TYR A O 1 ATOM 2966 C CB . TYR A 1 361 ? 19.859 -18.599 -10.540 1.00 18.08 ? 378 TYR A CB 1 ATOM 2967 C CG . TYR A 1 361 ? 18.998 -17.685 -11.417 1.00 17.64 ? 378 TYR A CG 1 ATOM 2968 C CD1 . TYR A 1 361 ? 17.993 -18.173 -12.254 1.00 17.68 ? 378 TYR A CD1 1 ATOM 2969 C CD2 . TYR A 1 361 ? 19.157 -16.300 -11.341 1.00 17.53 ? 378 TYR A CD2 1 ATOM 2970 C CE1 . TYR A 1 361 ? 17.204 -17.311 -13.013 1.00 17.63 ? 378 TYR A CE1 1 ATOM 2971 C CE2 . TYR A 1 361 ? 18.381 -15.431 -12.097 1.00 16.84 ? 378 TYR A CE2 1 ATOM 2972 C CZ . TYR A 1 361 ? 17.405 -15.932 -12.925 1.00 17.26 ? 378 TYR A CZ 1 ATOM 2973 O OH . TYR A 1 361 ? 16.625 -15.055 -13.637 1.00 17.48 ? 378 TYR A OH 1 ATOM 2974 N N . GLN A 1 362 ? 19.644 -21.599 -12.647 1.00 20.29 ? 379 GLN A N 1 ATOM 2975 C CA . GLN A 1 362 ? 18.585 -22.506 -13.111 1.00 21.57 ? 379 GLN A CA 1 ATOM 2976 C C . GLN A 1 362 ? 18.320 -23.731 -12.224 1.00 22.21 ? 379 GLN A C 1 ATOM 2977 O O . GLN A 1 362 ? 17.245 -24.293 -12.313 1.00 21.27 ? 379 GLN A O 1 ATOM 2978 C CB . GLN A 1 362 ? 18.743 -22.893 -14.590 1.00 23.53 ? 379 GLN A CB 1 ATOM 2979 C CG . GLN A 1 362 ? 19.892 -23.808 -14.942 1.00 24.66 ? 379 GLN A CG 1 ATOM 2980 C CD . GLN A 1 362 ? 20.029 -23.981 -16.450 1.00 25.53 ? 379 GLN A CD 1 ATOM 2981 O OE1 . GLN A 1 362 ? 19.126 -23.621 -17.227 1.00 26.68 ? 379 GLN A OE1 1 ATOM 2982 N NE2 . GLN A 1 362 ? 21.150 -24.535 -16.872 1.00 25.46 ? 379 GLN A NE2 1 ATOM 2983 N N . HIS A 1 363 ? 19.254 -24.097 -11.344 1.00 22.71 ? 380 HIS A N 1 ATOM 2984 C CA . HIS A 1 363 ? 19.012 -25.162 -10.360 1.00 24.68 ? 380 HIS A CA 1 ATOM 2985 C C . HIS A 1 363 ? 18.434 -24.693 -9.019 1.00 23.93 ? 380 HIS A C 1 ATOM 2986 O O . HIS A 1 363 ? 18.167 -25.518 -8.150 1.00 22.31 ? 380 HIS A O 1 ATOM 2987 C CB . HIS A 1 363 ? 20.289 -25.975 -10.148 1.00 27.18 ? 380 HIS A CB 1 ATOM 2988 C CG . HIS A 1 363 ? 20.752 -26.656 -11.395 1.00 29.83 ? 380 HIS A CG 1 ATOM 2989 N ND1 . HIS A 1 363 ? 20.039 -27.679 -11.981 1.00 32.11 ? 380 HIS A ND1 1 ATOM 2990 C CD2 . HIS A 1 363 ? 21.810 -26.421 -12.205 1.00 31.38 ? 380 HIS A CD2 1 ATOM 2991 C CE1 . HIS A 1 363 ? 20.653 -28.065 -13.085 1.00 31.85 ? 380 HIS A CE1 1 ATOM 2992 N NE2 . HIS A 1 363 ? 21.733 -27.320 -13.241 1.00 31.82 ? 380 HIS A NE2 1 ATOM 2993 N N . GLN A 1 364 ? 18.239 -23.385 -8.846 1.00 21.69 ? 381 GLN A N 1 ATOM 2994 C CA . GLN A 1 364 ? 17.496 -22.870 -7.685 1.00 21.47 ? 381 GLN A CA 1 ATOM 2995 C C . GLN A 1 364 ? 16.040 -23.312 -7.794 1.00 20.73 ? 381 GLN A C 1 ATOM 2996 O O . GLN A 1 364 ? 15.577 -23.574 -8.901 1.00 20.53 ? 381 GLN A O 1 ATOM 2997 C CB . GLN A 1 364 ? 17.555 -21.344 -7.645 1.00 21.45 ? 381 GLN A CB 1 ATOM 2998 C CG . GLN A 1 364 ? 18.929 -20.774 -7.298 1.00 21.61 ? 381 GLN A CG 1 ATOM 2999 C CD . GLN A 1 364 ? 19.263 -20.881 -5.820 1.00 21.40 ? 381 GLN A CD 1 ATOM 3000 O OE1 . GLN A 1 364 ? 18.397 -21.158 -4.995 1.00 22.39 ? 381 GLN A OE1 1 ATOM 3001 N NE2 . GLN A 1 364 ? 20.516 -20.649 -5.481 1.00 21.70 ? 381 GLN A NE2 1 ATOM 3002 N N . PRO A 1 365 ? 15.307 -23.383 -6.662 1.00 20.05 ? 382 PRO A N 1 ATOM 3003 C CA . PRO A 1 365 ? 13.858 -23.561 -6.786 1.00 20.40 ? 382 PRO A CA 1 ATOM 3004 C C . PRO A 1 365 ? 13.252 -22.426 -7.605 1.00 20.31 ? 382 PRO A C 1 ATOM 3005 O O . PRO A 1 365 ? 13.771 -21.299 -7.573 1.00 19.27 ? 382 PRO A O 1 ATOM 3006 C CB . PRO A 1 365 ? 13.330 -23.471 -5.345 1.00 20.36 ? 382 PRO A CB 1 ATOM 3007 C CG . PRO A 1 365 ? 14.485 -23.169 -4.480 1.00 20.72 ? 382 PRO A CG 1 ATOM 3008 C CD . PRO A 1 365 ? 15.749 -23.251 -5.264 1.00 20.14 ? 382 PRO A CD 1 ATOM 3009 N N . PHE A 1 366 ? 12.163 -22.729 -8.303 1.00 19.96 ? 383 PHE A N 1 ATOM 3010 C CA . PHE A 1 366 ? 11.496 -21.761 -9.163 1.00 19.82 ? 383 PHE A CA 1 ATOM 3011 C C . PHE A 1 366 ? 11.357 -20.361 -8.561 1.00 19.55 ? 383 PHE A C 1 ATOM 3012 O O . PHE A 1 366 ? 11.681 -19.386 -9.231 1.00 18.18 ? 383 PHE A O 1 ATOM 3013 C CB . PHE A 1 366 ? 10.115 -22.256 -9.607 1.00 20.16 ? 383 PHE A CB 1 ATOM 3014 C CG . PHE A 1 366 ? 9.345 -21.223 -10.367 1.00 19.54 ? 383 PHE A CG 1 ATOM 3015 C CD1 . PHE A 1 366 ? 9.634 -20.977 -11.703 1.00 19.86 ? 383 PHE A CD1 1 ATOM 3016 C CD2 . PHE A 1 366 ? 8.381 -20.448 -9.736 1.00 19.70 ? 383 PHE A CD2 1 ATOM 3017 C CE1 . PHE A 1 366 ? 8.957 -19.998 -12.401 1.00 20.51 ? 383 PHE A CE1 1 ATOM 3018 C CE2 . PHE A 1 366 ? 7.693 -19.461 -10.432 1.00 21.00 ? 383 PHE A CE2 1 ATOM 3019 C CZ . PHE A 1 366 ? 7.984 -19.238 -11.767 1.00 20.66 ? 383 PHE A CZ 1 ATOM 3020 N N . VAL A 1 367 ? 10.873 -20.246 -7.322 1.00 19.72 ? 384 VAL A N 1 ATOM 3021 C CA . VAL A 1 367 ? 10.684 -18.916 -6.728 1.00 20.36 ? 384 VAL A CA 1 ATOM 3022 C C . VAL A 1 367 ? 11.976 -18.086 -6.637 1.00 19.16 ? 384 VAL A C 1 ATOM 3023 O O . VAL A 1 367 ? 11.905 -16.865 -6.638 1.00 19.88 ? 384 VAL A O 1 ATOM 3024 C CB . VAL A 1 367 ? 9.965 -18.922 -5.355 1.00 21.86 ? 384 VAL A CB 1 ATOM 3025 C CG1 . VAL A 1 367 ? 8.516 -19.371 -5.524 1.00 24.13 ? 384 VAL A CG1 1 ATOM 3026 C CG2 . VAL A 1 367 ? 10.719 -19.743 -4.318 1.00 22.44 ? 384 VAL A CG2 1 ATOM 3027 N N . TYR A 1 368 ? 13.132 -18.741 -6.579 1.00 18.18 ? 385 TYR A N 1 ATOM 3028 C CA . TYR A 1 368 ? 14.422 -18.044 -6.551 1.00 17.93 ? 385 TYR A CA 1 ATOM 3029 C C . TYR A 1 368 ? 15.081 -17.864 -7.910 1.00 17.60 ? 385 TYR A C 1 ATOM 3030 O O . TYR A 1 368 ? 16.178 -17.326 -7.974 1.00 17.51 ? 385 TYR A O 1 ATOM 3031 C CB . TYR A 1 368 ? 15.393 -18.764 -5.613 1.00 18.01 ? 385 TYR A CB 1 ATOM 3032 C CG . TYR A 1 368 ? 14.981 -18.824 -4.150 1.00 17.68 ? 385 TYR A CG 1 ATOM 3033 C CD1 . TYR A 1 368 ? 14.093 -17.899 -3.588 1.00 17.68 ? 385 TYR A CD1 1 ATOM 3034 C CD2 . TYR A 1 368 ? 15.545 -19.782 -3.307 1.00 17.77 ? 385 TYR A CD2 1 ATOM 3035 C CE1 . TYR A 1 368 ? 13.754 -17.951 -2.242 1.00 17.82 ? 385 TYR A CE1 1 ATOM 3036 C CE2 . TYR A 1 368 ? 15.214 -19.840 -1.965 1.00 17.80 ? 385 TYR A CE2 1 ATOM 3037 C CZ . TYR A 1 368 ? 14.313 -18.928 -1.437 1.00 18.32 ? 385 TYR A CZ 1 ATOM 3038 O OH . TYR A 1 368 ? 13.967 -18.969 -0.103 1.00 18.98 ? 385 TYR A OH 1 ATOM 3039 N N . ARG A 1 369 ? 14.435 -18.299 -8.992 1.00 17.96 ? 386 ARG A N 1 ATOM 3040 C CA . ARG A 1 369 ? 14.997 -18.131 -10.341 1.00 17.59 ? 386 ARG A CA 1 ATOM 3041 C C . ARG A 1 369 ? 14.644 -16.761 -10.904 1.00 17.54 ? 386 ARG A C 1 ATOM 3042 O O . ARG A 1 369 ? 13.834 -16.624 -11.825 1.00 16.40 ? 386 ARG A O 1 ATOM 3043 C CB . ARG A 1 369 ? 14.559 -19.266 -11.264 1.00 18.41 ? 386 ARG A CB 1 ATOM 3044 C CG . ARG A 1 369 ? 15.100 -20.600 -10.792 1.00 18.98 ? 386 ARG A CG 1 ATOM 3045 C CD . ARG A 1 369 ? 14.547 -21.755 -11.600 1.00 19.52 ? 386 ARG A CD 1 ATOM 3046 N NE . ARG A 1 369 ? 15.047 -21.768 -12.978 1.00 19.92 ? 386 ARG A NE 1 ATOM 3047 C CZ . ARG A 1 369 ? 14.785 -22.736 -13.858 1.00 20.94 ? 386 ARG A CZ 1 ATOM 3048 N NH1 . ARG A 1 369 ? 14.030 -23.781 -13.504 1.00 21.18 ? 386 ARG A NH1 1 ATOM 3049 N NH2 . ARG A 1 369 ? 15.282 -22.668 -15.094 1.00 19.96 ? 386 ARG A NH2 1 ATOM 3050 N N . THR A 1 370 ? 15.283 -15.754 -10.317 1.00 17.45 ? 387 THR A N 1 ATOM 3051 C CA . THR A 1 370 ? 15.131 -14.352 -10.698 1.00 17.40 ? 387 THR A CA 1 ATOM 3052 C C . THR A 1 370 ? 16.283 -13.588 -10.040 1.00 17.66 ? 387 THR A C 1 ATOM 3053 O O . THR A 1 370 ? 17.084 -14.178 -9.293 1.00 17.13 ? 387 THR A O 1 ATOM 3054 C CB . THR A 1 370 ? 13.739 -13.783 -10.339 1.00 18.14 ? 387 THR A CB 1 ATOM 3055 O OG1 . THR A 1 370 ? 13.573 -12.506 -10.961 1.00 18.00 ? 387 THR A OG1 1 ATOM 3056 C CG2 . THR A 1 370 ? 13.533 -13.655 -8.828 1.00 18.78 ? 387 THR A CG2 1 ATOM 3057 N N . GLY A 1 371 ? 16.393 -12.299 -10.334 1.00 17.31 ? 388 GLY A N 1 ATOM 3058 C CA . GLY A 1 371 ? 17.536 -11.520 -9.888 1.00 17.38 ? 388 GLY A CA 1 ATOM 3059 C C . GLY A 1 371 ? 17.468 -11.242 -8.405 1.00 16.89 ? 388 GLY A C 1 ATOM 3060 O O . GLY A 1 371 ? 16.379 -11.238 -7.813 1.00 16.76 ? 388 GLY A O 1 ATOM 3061 N N . ALA A 1 372 ? 18.633 -11.016 -7.800 1.00 16.50 ? 389 ALA A N 1 ATOM 3062 C CA . ALA A 1 372 ? 18.701 -10.660 -6.377 1.00 16.12 ? 389 ALA A CA 1 ATOM 3063 C C . ALA A 1 372 ? 17.819 -9.431 -6.126 1.00 15.95 ? 389 ALA A C 1 ATOM 3064 O O . ALA A 1 372 ? 17.052 -9.378 -5.162 1.00 16.15 ? 389 ALA A O 1 ATOM 3065 C CB . ALA A 1 372 ? 20.146 -10.405 -5.960 1.00 16.20 ? 389 ALA A CB 1 ATOM 3066 N N . ASN A 1 373 ? 17.936 -8.438 -7.002 1.00 16.14 ? 390 ASN A N 1 ATOM 3067 C CA . ASN A 1 373 ? 16.862 -7.447 -7.214 1.00 16.43 ? 390 ASN A CA 1 ATOM 3068 C C . ASN A 1 373 ? 16.809 -7.111 -8.710 1.00 16.47 ? 390 ASN A C 1 ATOM 3069 O O . ASN A 1 373 ? 17.688 -7.552 -9.460 1.00 15.43 ? 390 ASN A O 1 ATOM 3070 C CB . ASN A 1 373 ? 16.968 -6.227 -6.269 1.00 16.98 ? 390 ASN A CB 1 ATOM 3071 C CG . ASN A 1 373 ? 18.057 -5.228 -6.650 1.00 17.51 ? 390 ASN A CG 1 ATOM 3072 O OD1 . ASN A 1 373 ? 18.259 -4.886 -7.820 1.00 17.68 ? 390 ASN A OD1 1 ATOM 3073 N ND2 . ASN A 1 373 ? 18.724 -4.699 -5.631 1.00 17.30 ? 390 ASN A ND2 1 ATOM 3074 N N . PRO A 1 374 ? 15.765 -6.389 -9.158 1.00 16.82 ? 391 PRO A N 1 ATOM 3075 C CA . PRO A 1 374 ? 15.643 -6.134 -10.602 1.00 17.14 ? 391 PRO A CA 1 ATOM 3076 C C . PRO A 1 374 ? 16.844 -5.420 -11.221 1.00 16.75 ? 391 PRO A C 1 ATOM 3077 O O . PRO A 1 374 ? 17.187 -5.680 -12.382 1.00 16.59 ? 391 PRO A O 1 ATOM 3078 C CB . PRO A 1 374 ? 14.374 -5.278 -10.696 1.00 17.57 ? 391 PRO A CB 1 ATOM 3079 C CG . PRO A 1 374 ? 13.547 -5.739 -9.549 1.00 18.02 ? 391 PRO A CG 1 ATOM 3080 C CD . PRO A 1 374 ? 14.551 -5.962 -8.437 1.00 17.62 ? 391 PRO A CD 1 ATOM 3081 N N . GLY A 1 375 ? 17.490 -4.547 -10.456 1.00 15.83 ? 392 GLY A N 1 ATOM 3082 C CA . GLY A 1 375 ? 18.683 -3.871 -10.944 1.00 16.21 ? 392 GLY A CA 1 ATOM 3083 C C . GLY A 1 375 ? 19.885 -4.772 -11.205 1.00 16.62 ? 392 GLY A C 1 ATOM 3084 O O . GLY A 1 375 ? 20.685 -4.488 -12.110 1.00 16.02 ? 392 GLY A O 1 ATOM 3085 N N . PHE A 1 376 ? 20.019 -5.846 -10.421 1.00 16.93 ? 393 PHE A N 1 ATOM 3086 C CA . PHE A 1 376 ? 21.129 -6.800 -10.606 1.00 17.39 ? 393 PHE A CA 1 ATOM 3087 C C . PHE A 1 376 ? 21.029 -7.433 -11.978 1.00 17.44 ? 393 PHE A C 1 ATOM 3088 O O . PHE A 1 376 ? 22.026 -7.554 -12.688 1.00 16.96 ? 393 PHE A O 1 ATOM 3089 C CB . PHE A 1 376 ? 21.140 -7.903 -9.546 1.00 17.82 ? 393 PHE A CB 1 ATOM 3090 C CG . PHE A 1 376 ? 21.791 -7.504 -8.245 1.00 18.30 ? 393 PHE A CG 1 ATOM 3091 C CD1 . PHE A 1 376 ? 21.375 -6.381 -7.547 1.00 19.04 ? 393 PHE A CD1 1 ATOM 3092 C CD2 . PHE A 1 376 ? 22.804 -8.281 -7.699 1.00 18.93 ? 393 PHE A CD2 1 ATOM 3093 C CE1 . PHE A 1 376 ? 21.971 -6.031 -6.338 1.00 19.95 ? 393 PHE A CE1 1 ATOM 3094 C CE2 . PHE A 1 376 ? 23.392 -7.938 -6.499 1.00 19.00 ? 393 PHE A CE2 1 ATOM 3095 C CZ . PHE A 1 376 ? 22.979 -6.814 -5.816 1.00 19.57 ? 393 PHE A CZ 1 ATOM 3096 N N . HIS A 1 377 ? 19.813 -7.824 -12.347 1.00 18.13 ? 394 HIS A N 1 ATOM 3097 C CA . HIS A 1 377 ? 19.567 -8.451 -13.640 1.00 18.00 ? 394 HIS A CA 1 ATOM 3098 C C . HIS A 1 377 ? 19.994 -7.545 -14.795 1.00 18.30 ? 394 HIS A C 1 ATOM 3099 O O . HIS A 1 377 ? 20.649 -7.997 -15.738 1.00 18.13 ? 394 HIS A O 1 ATOM 3100 C CB . HIS A 1 377 ? 18.100 -8.890 -13.775 1.00 18.13 ? 394 HIS A CB 1 ATOM 3101 C CG . HIS A 1 377 ? 17.942 -10.330 -14.152 1.00 18.72 ? 394 HIS A CG 1 ATOM 3102 N ND1 . HIS A 1 377 ? 18.500 -10.863 -15.289 1.00 18.78 ? 394 HIS A ND1 1 ATOM 3103 C CD2 . HIS A 1 377 ? 17.293 -11.351 -13.545 1.00 18.99 ? 394 HIS A CD2 1 ATOM 3104 C CE1 . HIS A 1 377 ? 18.215 -12.148 -15.366 1.00 18.85 ? 394 HIS A CE1 1 ATOM 3105 N NE2 . HIS A 1 377 ? 17.480 -12.471 -14.320 1.00 18.70 ? 394 HIS A NE2 1 ATOM 3106 N N . GLU A 1 378 ? 19.679 -6.257 -14.693 1.00 18.06 ? 395 GLU A N 1 ATOM 3107 C CA . GLU A 1 378 ? 20.029 -5.297 -15.745 1.00 18.30 ? 395 GLU A CA 1 ATOM 3108 C C . GLU A 1 378 ? 21.528 -4.976 -15.806 1.00 18.12 ? 395 GLU A C 1 ATOM 3109 O O . GLU A 1 378 ? 22.036 -4.592 -16.858 1.00 19.11 ? 395 GLU A O 1 ATOM 3110 C CB . GLU A 1 378 ? 19.220 -4.005 -15.562 1.00 18.15 ? 395 GLU A CB 1 ATOM 3111 C CG . GLU A 1 378 ? 17.703 -4.178 -15.552 1.00 17.97 ? 395 GLU A CG 1 ATOM 3112 C CD . GLU A 1 378 ? 17.176 -4.856 -16.797 1.00 18.17 ? 395 GLU A CD 1 ATOM 3113 O OE1 . GLU A 1 378 ? 17.817 -4.728 -17.851 1.00 17.69 ? 395 GLU A OE1 1 ATOM 3114 O OE2 . GLU A 1 378 ? 16.131 -5.546 -16.730 1.00 18.28 ? 395 GLU A OE2 1 ATOM 3115 N N . ALA A 1 379 ? 22.231 -5.139 -14.686 1.00 17.83 ? 396 ALA A N 1 ATOM 3116 C CA . ALA A 1 379 ? 23.623 -4.704 -14.564 1.00 17.39 ? 396 ALA A CA 1 ATOM 3117 C C . ALA A 1 379 ? 24.618 -5.675 -15.169 1.00 17.57 ? 396 ALA A C 1 ATOM 3118 O O . ALA A 1 379 ? 25.655 -5.236 -15.653 1.00 18.02 ? 396 ALA A O 1 ATOM 3119 C CB . ALA A 1 379 ? 23.975 -4.444 -13.103 1.00 17.40 ? 396 ALA A CB 1 ATOM 3120 N N . VAL A 1 380 ? 24.314 -6.973 -15.161 1.00 17.93 ? 397 VAL A N 1 ATOM 3121 C CA . VAL A 1 380 ? 25.328 -8.011 -15.483 1.00 17.93 ? 397 VAL A CA 1 ATOM 3122 C C . VAL A 1 380 ? 25.988 -7.746 -16.837 1.00 17.86 ? 397 VAL A C 1 ATOM 3123 O O . VAL A 1 380 ? 27.218 -7.665 -16.955 1.00 17.44 ? 397 VAL A O 1 ATOM 3124 C CB . VAL A 1 380 ? 24.719 -9.430 -15.494 1.00 18.78 ? 397 VAL A CB 1 ATOM 3125 C CG1 . VAL A 1 380 ? 25.762 -10.470 -15.912 1.00 19.57 ? 397 VAL A CG1 1 ATOM 3126 C CG2 . VAL A 1 380 ? 24.134 -9.785 -14.128 1.00 19.43 ? 397 VAL A CG2 1 ATOM 3127 N N . GLY A 1 381 ? 25.156 -7.608 -17.858 1.00 17.39 ? 398 GLY A N 1 ATOM 3128 C CA . GLY A 1 381 ? 25.648 -7.463 -19.218 1.00 17.31 ? 398 GLY A CA 1 ATOM 3129 C C . GLY A 1 381 ? 26.350 -6.146 -19.449 1.00 17.60 ? 398 GLY A C 1 ATOM 3130 O O . GLY A 1 381 ? 27.298 -6.072 -20.250 1.00 17.11 ? 398 GLY A O 1 ATOM 3131 N N . ASP A 1 382 ? 25.886 -5.107 -18.752 1.00 17.24 ? 399 ASP A N 1 ATOM 3132 C CA . ASP A 1 382 ? 26.482 -3.779 -18.868 1.00 17.76 ? 399 ASP A CA 1 ATOM 3133 C C . ASP A 1 382 ? 27.907 -3.736 -18.324 1.00 17.81 ? 399 ASP A C 1 ATOM 3134 O O . ASP A 1 382 ? 28.701 -2.938 -18.778 1.00 17.37 ? 399 ASP A O 1 ATOM 3135 C CB . ASP A 1 382 ? 25.627 -2.717 -18.170 1.00 17.95 ? 399 ASP A CB 1 ATOM 3136 C CG . ASP A 1 382 ? 24.390 -2.318 -18.973 1.00 18.41 ? 399 ASP A CG 1 ATOM 3137 O OD1 . ASP A 1 382 ? 23.971 -3.061 -19.875 1.00 18.82 ? 399 ASP A OD1 1 ATOM 3138 O OD2 . ASP A 1 382 ? 23.834 -1.239 -18.698 1.00 19.30 ? 399 ASP A OD2 1 ATOM 3139 N N . VAL A 1 383 ? 28.220 -4.591 -17.353 1.00 18.12 ? 400 VAL A N 1 ATOM 3140 C CA . VAL A 1 383 ? 29.594 -4.674 -16.844 1.00 18.85 ? 400 VAL A CA 1 ATOM 3141 C C . VAL A 1 383 ? 30.516 -5.130 -17.967 1.00 19.39 ? 400 VAL A C 1 ATOM 3142 O O . VAL A 1 383 ? 31.591 -4.560 -18.165 1.00 19.31 ? 400 VAL A O 1 ATOM 3143 C CB . VAL A 1 383 ? 29.703 -5.614 -15.627 1.00 19.04 ? 400 VAL A CB 1 ATOM 3144 C CG1 . VAL A 1 383 ? 31.152 -5.760 -15.178 1.00 19.35 ? 400 VAL A CG1 1 ATOM 3145 C CG2 . VAL A 1 383 ? 28.851 -5.098 -14.482 1.00 18.56 ? 400 VAL A CG2 1 ATOM 3146 N N . LEU A 1 384 ? 30.084 -6.139 -18.717 1.00 20.72 ? 401 LEU A N 1 ATOM 3147 C CA . LEU A 1 384 ? 30.863 -6.629 -19.852 1.00 22.16 ? 401 LEU A CA 1 ATOM 3148 C C . LEU A 1 384 ? 30.956 -5.555 -20.937 1.00 21.82 ? 401 LEU A C 1 ATOM 3149 O O . LEU A 1 384 ? 32.021 -5.350 -21.509 1.00 22.29 ? 401 LEU A O 1 ATOM 3150 C CB . LEU A 1 384 ? 30.243 -7.890 -20.442 1.00 23.30 ? 401 LEU A CB 1 ATOM 3151 C CG . LEU A 1 384 ? 30.086 -9.208 -19.647 1.00 25.19 ? 401 LEU A CG 1 ATOM 3152 C CD1 . LEU A 1 384 ? 30.706 -10.375 -20.384 1.00 24.97 ? 401 LEU A CD1 1 ATOM 3153 C CD2 . LEU A 1 384 ? 30.541 -9.190 -18.188 1.00 24.91 ? 401 LEU A CD2 1 ATOM 3154 N N . SER A 1 385 ? 29.846 -4.868 -21.205 1.00 21.51 ? 402 SER A N 1 ATOM 3155 C CA . SER A 1 385 ? 29.832 -3.788 -22.203 1.00 20.80 ? 402 SER A CA 1 ATOM 3156 C C . SER A 1 385 ? 30.785 -2.649 -21.872 1.00 20.62 ? 402 SER A C 1 ATOM 3157 O O . SER A 1 385 ? 31.402 -2.093 -22.773 1.00 20.88 ? 402 SER A O 1 ATOM 3158 C CB . SER A 1 385 ? 28.428 -3.230 -22.397 1.00 21.14 ? 402 SER A CB 1 ATOM 3159 O OG . SER A 1 385 ? 27.612 -4.171 -23.061 1.00 21.16 ? 402 SER A OG 1 ATOM 3160 N N . LEU A 1 386 ? 30.897 -2.289 -20.596 1.00 20.39 ? 403 LEU A N 1 ATOM 3161 C CA . LEU A 1 386 ? 31.901 -1.318 -20.183 1.00 20.74 ? 403 LEU A CA 1 ATOM 3162 C C . LEU A 1 386 ? 33.302 -1.758 -20.624 1.00 21.62 ? 403 LEU A C 1 ATOM 3163 O O . LEU A 1 386 ? 34.054 -0.936 -21.159 1.00 22.52 ? 403 LEU A O 1 ATOM 3164 C CB . LEU A 1 386 ? 31.854 -1.053 -18.671 1.00 20.91 ? 403 LEU A CB 1 ATOM 3165 C CG . LEU A 1 386 ? 30.689 -0.190 -18.181 1.00 21.12 ? 403 LEU A CG 1 ATOM 3166 C CD1 . LEU A 1 386 ? 30.601 -0.247 -16.660 1.00 21.24 ? 403 LEU A CD1 1 ATOM 3167 C CD2 . LEU A 1 386 ? 30.811 1.254 -18.668 1.00 21.60 ? 403 LEU A CD2 1 ATOM 3168 N N . SER A 1 387 ? 33.637 -3.035 -20.431 1.00 21.96 ? 404 SER A N 1 ATOM 3169 C CA . SER A 1 387 ? 34.922 -3.574 -20.936 1.00 23.14 ? 404 SER A CA 1 ATOM 3170 C C . SER A 1 387 ? 35.010 -3.587 -22.457 1.00 23.34 ? 404 SER A C 1 ATOM 3171 O O . SER A 1 387 ? 36.007 -3.129 -23.022 1.00 23.47 ? 404 SER A O 1 ATOM 3172 C CB . SER A 1 387 ? 35.219 -4.974 -20.404 1.00 23.95 ? 404 SER A CB 1 ATOM 3173 O OG . SER A 1 387 ? 35.973 -4.870 -19.218 1.00 26.79 ? 404 SER A OG 1 ATOM 3174 N N . VAL A 1 388 ? 33.953 -4.068 -23.107 1.00 22.18 ? 405 VAL A N 1 ATOM 3175 C CA . VAL A 1 388 ? 33.898 -4.127 -24.572 1.00 22.80 ? 405 VAL A CA 1 ATOM 3176 C C . VAL A 1 388 ? 34.157 -2.741 -25.193 1.00 22.78 ? 405 VAL A C 1 ATOM 3177 O O . VAL A 1 388 ? 34.819 -2.641 -26.219 1.00 22.79 ? 405 VAL A O 1 ATOM 3178 C CB . VAL A 1 388 ? 32.548 -4.709 -25.070 1.00 23.51 ? 405 VAL A CB 1 ATOM 3179 C CG1 . VAL A 1 388 ? 32.370 -4.531 -26.577 1.00 23.83 ? 405 VAL A CG1 1 ATOM 3180 C CG2 . VAL A 1 388 ? 32.427 -6.190 -24.708 1.00 23.61 ? 405 VAL A CG2 1 ATOM 3181 N N . SER A 1 389 ? 33.657 -1.691 -24.545 1.00 22.32 ? 406 SER A N 1 ATOM 3182 C CA . SER A 1 389 ? 33.727 -0.334 -25.072 1.00 22.31 ? 406 SER A CA 1 ATOM 3183 C C . SER A 1 389 ? 35.103 0.319 -24.936 1.00 22.64 ? 406 SER A C 1 ATOM 3184 O O . SER A 1 389 ? 35.299 1.396 -25.473 1.00 23.31 ? 406 SER A O 1 ATOM 3185 C CB . SER A 1 389 ? 32.719 0.559 -24.353 1.00 22.35 ? 406 SER A CB 1 ATOM 3186 O OG . SER A 1 389 ? 33.188 0.940 -23.062 1.00 22.36 ? 406 SER A OG 1 ATOM 3187 N N . THR A 1 390 ? 36.026 -0.280 -24.179 1.00 22.44 ? 407 THR A N 1 ATOM 3188 C CA . THR A 1 390 ? 37.326 0.345 -23.938 1.00 22.31 ? 407 THR A CA 1 ATOM 3189 C C . THR A 1 390 ? 38.164 0.285 -25.218 1.00 22.95 ? 407 THR A C 1 ATOM 3190 O O . THR A 1 390 ? 38.099 -0.704 -25.950 1.00 22.46 ? 407 THR A O 1 ATOM 3191 C CB . THR A 1 390 ? 38.110 -0.327 -22.791 1.00 21.43 ? 407 THR A CB 1 ATOM 3192 O OG1 . THR A 1 390 ? 38.352 -1.707 -23.099 1.00 21.00 ? 407 THR A OG1 1 ATOM 3193 C CG2 . THR A 1 390 ? 37.357 -0.204 -21.460 1.00 21.56 ? 407 THR A CG2 1 ATOM 3194 N N . PRO A 1 391 ? 38.945 1.346 -25.492 1.00 24.17 ? 408 PRO A N 1 ATOM 3195 C CA . PRO A 1 391 ? 39.941 1.269 -26.552 1.00 25.91 ? 408 PRO A CA 1 ATOM 3196 C C . PRO A 1 391 ? 40.800 0.008 -26.455 1.00 25.58 ? 408 PRO A C 1 ATOM 3197 O O . PRO A 1 391 ? 41.065 -0.617 -27.477 1.00 25.32 ? 408 PRO A O 1 ATOM 3198 C CB . PRO A 1 391 ? 40.785 2.524 -26.329 1.00 26.14 ? 408 PRO A CB 1 ATOM 3199 C CG . PRO A 1 391 ? 39.823 3.503 -25.747 1.00 26.42 ? 408 PRO A CG 1 ATOM 3200 C CD . PRO A 1 391 ? 38.896 2.686 -24.884 1.00 24.83 ? 408 PRO A CD 1 ATOM 3201 N N . LYS A 1 392 ? 41.189 -0.368 -25.233 1.00 26.02 ? 409 LYS A N 1 ATOM 3202 C CA . LYS A 1 392 ? 41.959 -1.590 -24.983 1.00 26.15 ? 409 LYS A CA 1 ATOM 3203 C C . LYS A 1 392 ? 41.288 -2.814 -25.595 1.00 26.29 ? 409 LYS A C 1 ATOM 3204 O O . LYS A 1 392 ? 41.926 -3.570 -26.335 1.00 26.42 ? 409 LYS A O 1 ATOM 3205 C CB . LYS A 1 392 ? 42.155 -1.810 -23.474 1.00 27.21 ? 409 LYS A CB 1 ATOM 3206 C CG . LYS A 1 392 ? 42.972 -3.044 -23.094 1.00 28.29 ? 409 LYS A CG 1 ATOM 3207 C CD . LYS A 1 392 ? 43.082 -3.218 -21.586 1.00 28.95 ? 409 LYS A CD 1 ATOM 3208 C CE . LYS A 1 392 ? 44.062 -2.236 -20.958 1.00 30.03 ? 409 LYS A CE 1 ATOM 3209 N NZ . LYS A 1 392 ? 44.025 -2.270 -19.470 1.00 30.02 ? 409 LYS A NZ 1 ATOM 3210 N N . HIS A 1 393 ? 40.005 -3.023 -25.301 1.00 24.66 ? 410 HIS A N 1 ATOM 3211 C CA . HIS A 1 393 ? 39.341 -4.199 -25.832 1.00 23.84 ? 410 HIS A CA 1 ATOM 3212 C C . HIS A 1 393 ? 39.114 -4.120 -27.342 1.00 24.26 ? 410 HIS A C 1 ATOM 3213 O O . HIS A 1 393 ? 39.303 -5.119 -28.041 1.00 24.96 ? 410 HIS A O 1 ATOM 3214 C CB . HIS A 1 393 ? 38.015 -4.507 -25.135 1.00 23.83 ? 410 HIS A CB 1 ATOM 3215 C CG . HIS A 1 393 ? 37.449 -5.827 -25.545 1.00 23.54 ? 410 HIS A CG 1 ATOM 3216 N ND1 . HIS A 1 393 ? 37.965 -7.025 -25.099 1.00 23.92 ? 410 HIS A ND1 1 ATOM 3217 C CD2 . HIS A 1 393 ? 36.474 -6.146 -26.429 1.00 23.49 ? 410 HIS A CD2 1 ATOM 3218 C CE1 . HIS A 1 393 ? 37.311 -8.022 -25.662 1.00 23.79 ? 410 HIS A CE1 1 ATOM 3219 N NE2 . HIS A 1 393 ? 36.398 -7.515 -26.469 1.00 23.05 ? 410 HIS A NE2 1 ATOM 3220 N N . LEU A 1 394 ? 38.702 -2.949 -27.831 1.00 24.34 ? 411 LEU A N 1 ATOM 3221 C CA . LEU A 1 394 ? 38.349 -2.788 -29.245 1.00 25.61 ? 411 LEU A CA 1 ATOM 3222 C C . LEU A 1 394 ? 39.579 -2.915 -30.140 1.00 27.99 ? 411 LEU A C 1 ATOM 3223 O O . LEU A 1 394 ? 39.488 -3.460 -31.250 1.00 27.75 ? 411 LEU A O 1 ATOM 3224 C CB . LEU A 1 394 ? 37.622 -1.457 -29.484 1.00 25.18 ? 411 LEU A CB 1 ATOM 3225 C CG . LEU A 1 394 ? 36.242 -1.382 -28.822 1.00 24.76 ? 411 LEU A CG 1 ATOM 3226 C CD1 . LEU A 1 394 ? 35.701 0.038 -28.813 1.00 25.25 ? 411 LEU A CD1 1 ATOM 3227 C CD2 . LEU A 1 394 ? 35.261 -2.329 -29.492 1.00 25.03 ? 411 LEU A CD2 1 ATOM 3228 N N . GLU A 1 395 ? 40.721 -2.431 -29.648 1.00 30.46 ? 412 GLU A N 1 ATOM 3229 C CA . GLU A 1 395 ? 42.012 -2.650 -30.320 1.00 32.87 ? 412 GLU A CA 1 ATOM 3230 C C . GLU A 1 395 ? 42.380 -4.126 -30.356 1.00 32.75 ? 412 GLU A C 1 ATOM 3231 O O . GLU A 1 395 ? 42.751 -4.635 -31.400 1.00 33.89 ? 412 GLU A O 1 ATOM 3232 C CB . GLU A 1 395 ? 43.126 -1.836 -29.660 1.00 34.68 ? 412 GLU A CB 1 ATOM 3233 C CG . GLU A 1 395 ? 43.029 -0.355 -29.968 1.00 37.07 ? 412 GLU A CG 1 ATOM 3234 C CD . GLU A 1 395 ? 43.999 0.490 -29.162 1.00 41.46 ? 412 GLU A CD 1 ATOM 3235 O OE1 . GLU A 1 395 ? 43.964 0.422 -27.911 1.00 44.43 ? 412 GLU A OE1 1 ATOM 3236 O OE2 . GLU A 1 395 ? 44.798 1.227 -29.786 1.00 44.90 ? 412 GLU A OE2 1 ATOM 3237 N N . LYS A 1 396 ? 42.232 -4.816 -29.229 1.00 32.76 ? 413 LYS A N 1 ATOM 3238 C CA . LYS A 1 396 ? 42.534 -6.248 -29.145 1.00 33.14 ? 413 LYS A CA 1 ATOM 3239 C C . LYS A 1 396 ? 41.751 -7.085 -30.169 1.00 32.62 ? 413 LYS A C 1 ATOM 3240 O O . LYS A 1 396 ? 42.320 -7.954 -30.827 1.00 31.25 ? 413 LYS A O 1 ATOM 3241 C CB . LYS A 1 396 ? 42.280 -6.752 -27.719 1.00 35.11 ? 413 LYS A CB 1 ATOM 3242 C CG . LYS A 1 396 ? 42.489 -8.248 -27.500 1.00 38.36 ? 413 LYS A CG 1 ATOM 3243 C CD . LYS A 1 396 ? 41.860 -8.701 -26.185 1.00 40.35 ? 413 LYS A CD 1 ATOM 3244 C CE . LYS A 1 396 ? 41.631 -10.203 -26.147 1.00 41.59 ? 413 LYS A CE 1 ATOM 3245 N NZ . LYS A 1 396 ? 42.904 -10.956 -25.985 1.00 42.74 ? 413 LYS A NZ 1 ATOM 3246 N N . ILE A 1 397 ? 40.453 -6.816 -30.312 1.00 30.26 ? 414 ILE A N 1 ATOM 3247 C CA . ILE A 1 397 ? 39.623 -7.583 -31.254 1.00 29.52 ? 414 ILE A CA 1 ATOM 3248 C C . ILE A 1 397 ? 39.659 -7.067 -32.704 1.00 28.95 ? 414 ILE A C 1 ATOM 3249 O O . ILE A 1 397 ? 39.015 -7.643 -33.567 1.00 29.66 ? 414 ILE A O 1 ATOM 3250 C CB . ILE A 1 397 ? 38.164 -7.755 -30.752 1.00 28.57 ? 414 ILE A CB 1 ATOM 3251 C CG1 . ILE A 1 397 ? 37.439 -6.410 -30.604 1.00 28.15 ? 414 ILE A CG1 1 ATOM 3252 C CG2 . ILE A 1 397 ? 38.164 -8.526 -29.436 1.00 28.06 ? 414 ILE A CG2 1 ATOM 3253 C CD1 . ILE A 1 397 ? 35.936 -6.537 -30.520 1.00 28.60 ? 414 ILE A CD1 1 ATOM 3254 N N . GLY A 1 398 ? 40.402 -5.993 -32.966 1.00 29.10 ? 415 GLY A N 1 ATOM 3255 C CA . GLY A 1 398 ? 40.620 -5.502 -34.325 1.00 29.26 ? 415 GLY A CA 1 ATOM 3256 C C . GLY A 1 398 ? 39.554 -4.558 -34.856 1.00 29.43 ? 415 GLY A C 1 ATOM 3257 O O . GLY A 1 398 ? 39.498 -4.315 -36.064 1.00 27.56 ? 415 GLY A O 1 ATOM 3258 N N . LEU A 1 399 ? 38.718 -4.010 -33.967 1.00 29.50 ? 416 LEU A N 1 ATOM 3259 C CA . LEU A 1 399 ? 37.650 -3.091 -34.379 1.00 29.43 ? 416 LEU A CA 1 ATOM 3260 C C . LEU A 1 399 ? 38.066 -1.621 -34.311 1.00 30.12 ? 416 LEU A C 1 ATOM 3261 O O . LEU A 1 399 ? 37.394 -0.770 -34.903 1.00 30.44 ? 416 LEU A O 1 ATOM 3262 C CB . LEU A 1 399 ? 36.371 -3.325 -33.555 1.00 28.83 ? 416 LEU A CB 1 ATOM 3263 C CG . LEU A 1 399 ? 35.516 -4.558 -33.875 1.00 28.81 ? 416 LEU A CG 1 ATOM 3264 C CD1 . LEU A 1 399 ? 34.256 -4.546 -33.023 1.00 28.16 ? 416 LEU A CD1 1 ATOM 3265 C CD2 . LEU A 1 399 ? 35.131 -4.626 -35.350 1.00 28.62 ? 416 LEU A CD2 1 ATOM 3266 N N . LEU A 1 400 ? 39.162 -1.327 -33.609 1.00 30.59 ? 417 LEU A N 1 ATOM 3267 C CA . LEU A 1 400 ? 39.687 0.031 -33.486 1.00 31.67 ? 417 LEU A CA 1 ATOM 3268 C C . LEU A 1 400 ? 41.149 0.033 -33.913 1.00 34.58 ? 417 LEU A C 1 ATOM 3269 O O . LEU A 1 400 ? 41.956 -0.707 -33.344 1.00 34.44 ? 417 LEU A O 1 ATOM 3270 C CB . LEU A 1 400 ? 39.558 0.511 -32.043 1.00 30.62 ? 417 LEU A CB 1 ATOM 3271 C CG . LEU A 1 400 ? 40.001 1.933 -31.695 1.00 29.94 ? 417 LEU A CG 1 ATOM 3272 C CD1 . LEU A 1 400 ? 39.274 2.982 -32.522 1.00 29.08 ? 417 LEU A CD1 1 ATOM 3273 C CD2 . LEU A 1 400 ? 39.783 2.172 -30.208 1.00 29.31 ? 417 LEU A CD2 1 ATOM 3274 N N . LYS A 1 401 ? 41.467 0.859 -34.912 1.00 37.03 ? 418 LYS A N 1 ATOM 3275 C CA . LYS A 1 401 ? 42.796 0.924 -35.525 1.00 39.83 ? 418 LYS A CA 1 ATOM 3276 C C . LYS A 1 401 ? 43.366 2.323 -35.396 1.00 39.97 ? 418 LYS A C 1 ATOM 3277 O O . LYS A 1 401 ? 42.616 3.301 -35.286 1.00 38.59 ? 418 LYS A O 1 ATOM 3278 C CB . LYS A 1 401 ? 42.709 0.631 -37.023 1.00 42.74 ? 418 LYS A CB 1 ATOM 3279 C CG . LYS A 1 401 ? 42.166 -0.731 -37.423 1.00 45.28 ? 418 LYS A CG 1 ATOM 3280 C CD . LYS A 1 401 ? 41.662 -0.692 -38.866 1.00 48.48 ? 418 LYS A CD 1 ATOM 3281 C CE . LYS A 1 401 ? 42.008 -1.951 -39.644 1.00 50.07 ? 418 LYS A CE 1 ATOM 3282 N NZ . LYS A 1 401 ? 41.596 -3.192 -38.937 1.00 51.82 ? 418 LYS A NZ 1 ATOM 3283 N N . ASP A 1 402 ? 44.696 2.407 -35.450 1.00 41.50 ? 419 ASP A N 1 ATOM 3284 C CA . ASP A 1 402 ? 45.424 3.681 -35.508 1.00 42.82 ? 419 ASP A CA 1 ATOM 3285 C C . ASP A 1 402 ? 44.999 4.635 -34.387 1.00 41.31 ? 419 ASP A C 1 ATOM 3286 O O . ASP A 1 402 ? 44.887 5.839 -34.606 1.00 43.50 ? 419 ASP A O 1 ATOM 3287 C CB . ASP A 1 402 ? 45.215 4.359 -36.881 1.00 45.28 ? 419 ASP A CB 1 ATOM 3288 C CG . ASP A 1 402 ? 45.356 3.390 -38.056 1.00 48.62 ? 419 ASP A CG 1 ATOM 3289 O OD1 . ASP A 1 402 ? 46.270 2.534 -38.041 1.00 50.25 ? 419 ASP A OD1 1 ATOM 3290 O OD2 . ASP A 1 402 ? 44.544 3.489 -39.004 1.00 52.76 ? 419 ASP A OD2 1 ATOM 3291 N N . TYR A 1 403 ? 44.753 4.086 -33.196 1.00 38.14 ? 420 TYR A N 1 ATOM 3292 C CA . TYR A 1 403 ? 44.195 4.846 -32.085 1.00 36.89 ? 420 TYR A CA 1 ATOM 3293 C C . TYR A 1 403 ? 45.300 5.179 -31.097 1.00 36.22 ? 420 TYR A C 1 ATOM 3294 O O . TYR A 1 403 ? 45.918 4.281 -30.527 1.00 37.61 ? 420 TYR A O 1 ATOM 3295 C CB . TYR A 1 403 ? 43.082 4.047 -31.391 1.00 34.85 ? 420 TYR A CB 1 ATOM 3296 C CG . TYR A 1 403 ? 42.350 4.814 -30.316 1.00 33.68 ? 420 TYR A CG 1 ATOM 3297 C CD1 . TYR A 1 403 ? 41.306 5.687 -30.640 1.00 33.03 ? 420 TYR A CD1 1 ATOM 3298 C CD2 . TYR A 1 403 ? 42.702 4.680 -28.972 1.00 32.81 ? 420 TYR A CD2 1 ATOM 3299 C CE1 . TYR A 1 403 ? 40.630 6.394 -29.654 1.00 32.13 ? 420 TYR A CE1 1 ATOM 3300 C CE2 . TYR A 1 403 ? 42.037 5.387 -27.981 1.00 32.96 ? 420 TYR A CE2 1 ATOM 3301 C CZ . TYR A 1 403 ? 41.000 6.239 -28.326 1.00 32.02 ? 420 TYR A CZ 1 ATOM 3302 O OH . TYR A 1 403 ? 40.340 6.939 -27.345 1.00 30.94 ? 420 TYR A OH 1 ATOM 3303 N N . VAL A 1 404 ? 45.545 6.471 -30.913 1.00 37.43 ? 421 VAL A N 1 ATOM 3304 C CA . VAL A 1 404 ? 46.500 6.957 -29.924 1.00 39.44 ? 421 VAL A CA 1 ATOM 3305 C C . VAL A 1 404 ? 45.687 7.444 -28.742 1.00 39.13 ? 421 VAL A C 1 ATOM 3306 O O . VAL A 1 404 ? 44.847 8.333 -28.895 1.00 39.54 ? 421 VAL A O 1 ATOM 3307 C CB . VAL A 1 404 ? 47.351 8.114 -30.484 1.00 40.10 ? 421 VAL A CB 1 ATOM 3308 C CG1 . VAL A 1 404 ? 48.266 8.688 -29.401 1.00 40.54 ? 421 VAL A CG1 1 ATOM 3309 C CG2 . VAL A 1 404 ? 48.149 7.637 -31.690 1.00 39.89 ? 421 VAL A CG2 1 ATOM 3310 N N . ARG A 1 405 ? 45.940 6.867 -27.571 1.00 39.70 ? 422 ARG A N 1 ATOM 3311 C CA . ARG A 1 405 ? 45.181 7.190 -26.369 1.00 39.76 ? 422 ARG A CA 1 ATOM 3312 C C . ARG A 1 405 ? 45.893 8.287 -25.579 1.00 38.94 ? 422 ARG A C 1 ATOM 3313 O O . ARG A 1 405 ? 46.421 8.053 -24.494 1.00 40.35 ? 422 ARG A O 1 ATOM 3314 C CB . ARG A 1 405 ? 44.947 5.930 -25.526 1.00 41.25 ? 422 ARG A CB 1 ATOM 3315 C CG . ARG A 1 405 ? 43.881 6.109 -24.459 1.00 42.27 ? 422 ARG A CG 1 ATOM 3316 C CD . ARG A 1 405 ? 43.554 4.800 -23.749 1.00 43.32 ? 422 ARG A CD 1 ATOM 3317 N NE . ARG A 1 405 ? 42.667 5.034 -22.606 1.00 43.95 ? 422 ARG A NE 1 ATOM 3318 C CZ . ARG A 1 405 ? 43.041 5.518 -21.415 1.00 43.29 ? 422 ARG A CZ 1 ATOM 3319 N NH1 . ARG A 1 405 ? 44.313 5.825 -21.158 1.00 43.16 ? 422 ARG A NH1 1 ATOM 3320 N NH2 . ARG A 1 405 ? 42.128 5.692 -20.459 1.00 43.07 ? 422 ARG A NH2 1 ATOM 3321 N N . ASP A 1 406 ? 45.890 9.490 -26.149 1.00 36.33 ? 423 ASP A N 1 ATOM 3322 C CA . ASP A 1 406 ? 46.427 10.679 -25.488 1.00 35.33 ? 423 ASP A CA 1 ATOM 3323 C C . ASP A 1 406 ? 45.338 11.283 -24.600 1.00 34.61 ? 423 ASP A C 1 ATOM 3324 O O . ASP A 1 406 ? 44.227 10.748 -24.539 1.00 33.68 ? 423 ASP A O 1 ATOM 3325 C CB . ASP A 1 406 ? 46.987 11.688 -26.520 1.00 35.61 ? 423 ASP A CB 1 ATOM 3326 C CG . ASP A 1 406 ? 45.939 12.196 -27.516 1.00 36.90 ? 423 ASP A CG 1 ATOM 3327 O OD1 . ASP A 1 406 ? 44.714 12.039 -27.293 1.00 36.13 ? 423 ASP A OD1 1 ATOM 3328 O OD2 . ASP A 1 406 ? 46.358 12.767 -28.548 1.00 36.84 ? 423 ASP A OD2 1 ATOM 3329 N N . ASP A 1 407 ? 45.650 12.377 -23.908 1.00 34.10 ? 424 ASP A N 1 ATOM 3330 C CA . ASP A 1 407 ? 44.709 12.993 -22.962 1.00 35.13 ? 424 ASP A CA 1 ATOM 3331 C C . ASP A 1 407 ? 43.404 13.458 -23.607 1.00 33.61 ? 424 ASP A C 1 ATOM 3332 O O . ASP A 1 407 ? 42.339 13.301 -23.010 1.00 31.67 ? 424 ASP A O 1 ATOM 3333 C CB . ASP A 1 407 ? 45.358 14.167 -22.210 1.00 38.14 ? 424 ASP A CB 1 ATOM 3334 C CG . ASP A 1 407 ? 46.412 13.714 -21.204 1.00 42.18 ? 424 ASP A CG 1 ATOM 3335 O OD1 . ASP A 1 407 ? 46.557 12.491 -20.979 1.00 44.63 ? 424 ASP A OD1 1 ATOM 3336 O OD2 . ASP A 1 407 ? 47.104 14.587 -20.639 1.00 46.34 ? 424 ASP A OD2 1 ATOM 3337 N N . GLU A 1 408 ? 43.491 14.016 -24.814 1.00 31.41 ? 425 GLU A N 1 ATOM 3338 C CA . GLU A 1 408 ? 42.308 14.486 -25.538 1.00 30.92 ? 425 GLU A CA 1 ATOM 3339 C C . GLU A 1 408 ? 41.400 13.342 -25.999 1.00 29.61 ? 425 GLU A C 1 ATOM 3340 O O . GLU A 1 408 ? 40.178 13.439 -25.871 1.00 28.89 ? 425 GLU A O 1 ATOM 3341 C CB . GLU A 1 408 ? 42.713 15.379 -26.711 1.00 32.16 ? 425 GLU A CB 1 ATOM 3342 C CG . GLU A 1 408 ? 43.326 16.689 -26.233 1.00 33.81 ? 425 GLU A CG 1 ATOM 3343 C CD . GLU A 1 408 ? 43.632 17.687 -27.336 1.00 35.66 ? 425 GLU A CD 1 ATOM 3344 O OE1 . GLU A 1 408 ? 43.556 17.336 -28.534 1.00 36.10 ? 425 GLU A OE1 1 ATOM 3345 O OE2 . GLU A 1 408 ? 43.956 18.842 -26.980 1.00 37.68 ? 425 GLU A OE2 1 ATOM 3346 N N . ALA A 1 409 ? 41.995 12.272 -26.523 1.00 28.76 ? 426 ALA A N 1 ATOM 3347 C CA . ALA A 1 409 ? 41.251 11.058 -26.865 1.00 28.94 ? 426 ALA A CA 1 ATOM 3348 C C . ALA A 1 409 ? 40.566 10.450 -25.633 1.00 28.91 ? 426 ALA A C 1 ATOM 3349 O O . ALA A 1 409 ? 39.430 9.978 -25.721 1.00 29.32 ? 426 ALA A O 1 ATOM 3350 C CB . ALA A 1 409 ? 42.166 10.030 -27.510 1.00 29.21 ? 426 ALA A CB 1 ATOM 3351 N N . ARG A 1 410 ? 41.256 10.454 -24.496 1.00 27.78 ? 427 ARG A N 1 ATOM 3352 C CA . ARG A 1 410 ? 40.673 9.955 -23.253 1.00 28.26 ? 427 ARG A CA 1 ATOM 3353 C C . ARG A 1 410 ? 39.448 10.774 -22.842 1.00 27.19 ? 427 ARG A C 1 ATOM 3354 O O . ARG A 1 410 ? 38.444 10.202 -22.425 1.00 26.72 ? 427 ARG A O 1 ATOM 3355 C CB . ARG A 1 410 ? 41.692 9.960 -22.111 1.00 30.23 ? 427 ARG A CB 1 ATOM 3356 C CG . ARG A 1 410 ? 41.229 9.171 -20.900 1.00 31.14 ? 427 ARG A CG 1 ATOM 3357 C CD . ARG A 1 410 ? 41.934 9.602 -19.634 1.00 33.15 ? 427 ARG A CD 1 ATOM 3358 N NE . ARG A 1 410 ? 41.570 8.746 -18.507 1.00 33.82 ? 427 ARG A NE 1 ATOM 3359 C CZ . ARG A 1 410 ? 41.957 8.943 -17.249 1.00 35.26 ? 427 ARG A CZ 1 ATOM 3360 N NH1 . ARG A 1 410 ? 42.727 9.982 -16.925 1.00 35.42 ? 427 ARG A NH1 1 ATOM 3361 N NH2 . ARG A 1 410 ? 41.574 8.089 -16.302 1.00 34.64 ? 427 ARG A NH2 1 ATOM 3362 N N . ILE A 1 411 ? 39.530 12.099 -22.969 1.00 24.88 ? 428 ILE A N 1 ATOM 3363 C CA . ILE A 1 411 ? 38.409 12.959 -22.609 1.00 24.70 ? 428 ILE A CA 1 ATOM 3364 C C . ILE A 1 411 ? 37.230 12.713 -23.548 1.00 24.13 ? 428 ILE A C 1 ATOM 3365 O O . ILE A 1 411 ? 36.095 12.636 -23.085 1.00 23.18 ? 428 ILE A O 1 ATOM 3366 C CB . ILE A 1 411 ? 38.794 14.454 -22.582 1.00 24.48 ? 428 ILE A CB 1 ATOM 3367 C CG1 . ILE A 1 411 ? 39.775 14.730 -21.426 1.00 24.82 ? 428 ILE A CG1 1 ATOM 3368 C CG2 . ILE A 1 411 ? 37.562 15.346 -22.485 1.00 24.10 ? 428 ILE A CG2 1 ATOM 3369 C CD1 . ILE A 1 411 ? 39.205 14.636 -20.026 1.00 26.01 ? 428 ILE A CD1 1 ATOM 3370 N N . ASN A 1 412 ? 37.503 12.592 -24.846 1.00 23.38 ? 429 ASN A N 1 ATOM 3371 C CA . ASN A 1 412 ? 36.476 12.215 -25.817 1.00 23.57 ? 429 ASN A CA 1 ATOM 3372 C C . ASN A 1 412 ? 35.750 10.921 -25.442 1.00 23.36 ? 429 ASN A C 1 ATOM 3373 O O . ASN A 1 412 ? 34.526 10.857 -25.527 1.00 23.03 ? 429 ASN A O 1 ATOM 3374 C CB . ASN A 1 412 ? 37.072 12.062 -27.225 1.00 24.13 ? 429 ASN A CB 1 ATOM 3375 C CG . ASN A 1 412 ? 37.192 13.380 -27.974 1.00 24.52 ? 429 ASN A CG 1 ATOM 3376 O OD1 . ASN A 1 412 ? 36.780 14.438 -27.500 1.00 23.88 ? 429 ASN A OD1 1 ATOM 3377 N ND2 . ASN A 1 412 ? 37.755 13.308 -29.173 1.00 24.93 ? 429 ASN A ND2 1 ATOM 3378 N N . GLN A 1 413 ? 36.519 9.911 -25.035 1.00 23.53 ? 430 GLN A N 1 ATOM 3379 C CA . GLN A 1 413 ? 35.991 8.597 -24.668 1.00 24.13 ? 430 GLN A CA 1 ATOM 3380 C C . GLN A 1 413 ? 35.214 8.621 -23.344 1.00 23.32 ? 430 GLN A C 1 ATOM 3381 O O . GLN A 1 413 ? 34.155 8.008 -23.243 1.00 22.17 ? 430 GLN A O 1 ATOM 3382 C CB . GLN A 1 413 ? 37.133 7.565 -24.619 1.00 25.89 ? 430 GLN A CB 1 ATOM 3383 C CG . GLN A 1 413 ? 36.775 6.169 -24.117 1.00 27.24 ? 430 GLN A CG 1 ATOM 3384 C CD . GLN A 1 413 ? 35.797 5.421 -25.004 1.00 29.91 ? 430 GLN A CD 1 ATOM 3385 O OE1 . GLN A 1 413 ? 35.574 5.784 -26.163 1.00 33.01 ? 430 GLN A OE1 1 ATOM 3386 N NE2 . GLN A 1 413 ? 35.221 4.342 -24.463 1.00 31.86 ? 430 GLN A NE2 1 ATOM 3387 N N . LEU A 1 414 ? 35.745 9.300 -22.330 1.00 22.77 ? 431 LEU A N 1 ATOM 3388 C CA . LEU A 1 414 ? 35.013 9.471 -21.071 1.00 23.09 ? 431 LEU A CA 1 ATOM 3389 C C . LEU A 1 414 ? 33.723 10.247 -21.285 1.00 22.50 ? 431 LEU A C 1 ATOM 3390 O O . LEU A 1 414 ? 32.690 9.908 -20.695 1.00 20.31 ? 431 LEU A O 1 ATOM 3391 C CB . LEU A 1 414 ? 35.847 10.204 -20.031 1.00 23.96 ? 431 LEU A CB 1 ATOM 3392 C CG . LEU A 1 414 ? 36.913 9.390 -19.310 1.00 25.02 ? 431 LEU A CG 1 ATOM 3393 C CD1 . LEU A 1 414 ? 37.794 10.322 -18.495 1.00 25.49 ? 431 LEU A CD1 1 ATOM 3394 C CD2 . LEU A 1 414 ? 36.272 8.328 -18.421 1.00 25.62 ? 431 LEU A CD2 1 ATOM 3395 N N . PHE A 1 415 ? 33.793 11.288 -22.118 1.00 21.39 ? 432 PHE A N 1 ATOM 3396 C CA . PHE A 1 415 ? 32.617 12.090 -22.426 1.00 21.98 ? 432 PHE A CA 1 ATOM 3397 C C . PHE A 1 415 ? 31.558 11.261 -23.150 1.00 21.15 ? 432 PHE A C 1 ATOM 3398 O O . PHE A 1 415 ? 30.379 11.313 -22.783 1.00 20.44 ? 432 PHE A O 1 ATOM 3399 C CB . PHE A 1 415 ? 32.980 13.316 -23.255 1.00 22.52 ? 432 PHE A CB 1 ATOM 3400 C CG . PHE A 1 415 ? 31.863 14.307 -23.375 1.00 23.45 ? 432 PHE A CG 1 ATOM 3401 C CD1 . PHE A 1 415 ? 31.533 15.127 -22.304 1.00 24.15 ? 432 PHE A CD1 1 ATOM 3402 C CD2 . PHE A 1 415 ? 31.140 14.424 -24.554 1.00 24.72 ? 432 PHE A CD2 1 ATOM 3403 C CE1 . PHE A 1 415 ? 30.506 16.047 -22.403 1.00 24.89 ? 432 PHE A CE1 1 ATOM 3404 C CE2 . PHE A 1 415 ? 30.116 15.355 -24.658 1.00 23.96 ? 432 PHE A CE2 1 ATOM 3405 C CZ . PHE A 1 415 ? 29.796 16.158 -23.584 1.00 24.18 ? 432 PHE A CZ 1 ATOM 3406 N N . LEU A 1 416 ? 31.980 10.500 -24.160 1.00 21.12 ? 433 LEU A N 1 ATOM 3407 C CA . LEU A 1 416 ? 31.078 9.581 -24.878 1.00 21.55 ? 433 LEU A CA 1 ATOM 3408 C C . LEU A 1 416 ? 30.391 8.613 -23.911 1.00 20.57 ? 433 LEU A C 1 ATOM 3409 O O . LEU A 1 416 ? 29.178 8.396 -23.973 1.00 19.17 ? 433 LEU A O 1 ATOM 3410 C CB . LEU A 1 416 ? 31.854 8.790 -25.935 1.00 23.40 ? 433 LEU A CB 1 ATOM 3411 C CG . LEU A 1 416 ? 31.112 7.693 -26.703 1.00 24.68 ? 433 LEU A CG 1 ATOM 3412 C CD1 . LEU A 1 416 ? 30.016 8.310 -27.549 1.00 25.44 ? 433 LEU A CD1 1 ATOM 3413 C CD2 . LEU A 1 416 ? 32.067 6.880 -27.576 1.00 25.81 ? 433 LEU A CD2 1 ATOM 3414 N N . THR A 1 417 ? 31.172 8.037 -23.008 1.00 19.88 ? 434 THR A N 1 ATOM 3415 C CA . THR A 1 417 ? 30.625 7.109 -22.026 1.00 19.41 ? 434 THR A CA 1 ATOM 3416 C C . THR A 1 417 ? 29.624 7.799 -21.095 1.00 19.35 ? 434 THR A C 1 ATOM 3417 O O . THR A 1 417 ? 28.581 7.215 -20.769 1.00 18.78 ? 434 THR A O 1 ATOM 3418 C CB . THR A 1 417 ? 31.751 6.401 -21.239 1.00 19.06 ? 434 THR A CB 1 ATOM 3419 O OG1 . THR A 1 417 ? 32.621 5.755 -22.176 1.00 18.63 ? 434 THR A OG1 1 ATOM 3420 C CG2 . THR A 1 417 ? 31.179 5.347 -20.309 1.00 18.96 ? 434 THR A CG2 1 ATOM 3421 N N . ALA A 1 418 ? 29.918 9.041 -20.715 1.00 18.51 ? 435 ALA A N 1 ATOM 3422 C CA . ALA A 1 418 ? 29.017 9.832 -19.875 1.00 18.89 ? 435 ALA A CA 1 ATOM 3423 C C . ALA A 1 418 ? 27.713 10.161 -20.573 1.00 18.98 ? 435 ALA A C 1 ATOM 3424 O O . ALA A 1 418 ? 26.677 10.221 -19.919 1.00 17.06 ? 435 ALA A O 1 ATOM 3425 C CB . ALA A 1 418 ? 29.686 11.114 -19.408 1.00 19.30 ? 435 ALA A CB 1 ATOM 3426 N N . LEU A 1 419 ? 27.761 10.378 -21.889 1.00 19.14 ? 436 LEU A N 1 ATOM 3427 C CA . LEU A 1 419 ? 26.537 10.583 -22.670 1.00 20.46 ? 436 LEU A CA 1 ATOM 3428 C C . LEU A 1 419 ? 25.615 9.363 -22.666 1.00 20.36 ? 436 LEU A C 1 ATOM 3429 O O . LEU A 1 419 ? 24.426 9.505 -22.925 1.00 20.38 ? 436 LEU A O 1 ATOM 3430 C CB . LEU A 1 419 ? 26.848 10.992 -24.118 1.00 20.37 ? 436 LEU A CB 1 ATOM 3431 C CG . LEU A 1 419 ? 27.568 12.329 -24.322 1.00 20.85 ? 436 LEU A CG 1 ATOM 3432 C CD1 . LEU A 1 419 ? 27.867 12.531 -25.795 1.00 21.40 ? 436 LEU A CD1 1 ATOM 3433 C CD2 . LEU A 1 419 ? 26.776 13.497 -23.768 1.00 21.52 ? 436 LEU A CD2 1 ATOM 3434 N N . ASP A 1 420 ? 26.164 8.175 -22.409 1.00 21.52 ? 437 ASP A N 1 ATOM 3435 C CA . ASP A 1 420 ? 25.353 6.980 -22.151 1.00 23.16 ? 437 ASP A CA 1 ATOM 3436 C C . ASP A 1 420 ? 24.992 6.782 -20.672 1.00 22.83 ? 437 ASP A C 1 ATOM 3437 O O . ASP A 1 420 ? 23.866 6.389 -20.374 1.00 25.24 ? 437 ASP A O 1 ATOM 3438 C CB . ASP A 1 420 ? 26.060 5.717 -22.640 1.00 25.75 ? 437 ASP A CB 1 ATOM 3439 C CG . ASP A 1 420 ? 26.286 5.702 -24.141 1.00 29.88 ? 437 ASP A CG 1 ATOM 3440 O OD1 . ASP A 1 420 ? 25.407 6.182 -24.890 1.00 32.70 ? 437 ASP A OD1 1 ATOM 3441 O OD2 . ASP A 1 420 ? 27.351 5.185 -24.562 1.00 34.72 ? 437 ASP A OD2 1 ATOM 3442 N N . LYS A 1 421 ? 25.939 7.012 -19.761 1.00 21.20 ? 438 LYS A N 1 ATOM 3443 C CA . LYS A 1 421 ? 25.809 6.540 -18.380 1.00 20.01 ? 438 LYS A CA 1 ATOM 3444 C C . LYS A 1 421 ? 25.348 7.597 -17.378 1.00 20.15 ? 438 LYS A C 1 ATOM 3445 O O . LYS A 1 421 ? 24.507 7.303 -16.531 1.00 20.30 ? 438 LYS A O 1 ATOM 3446 C CB . LYS A 1 421 ? 27.116 5.876 -17.919 1.00 19.61 ? 438 LYS A CB 1 ATOM 3447 C CG . LYS A 1 421 ? 27.537 4.676 -18.761 1.00 19.11 ? 438 LYS A CG 1 ATOM 3448 C CD . LYS A 1 421 ? 26.533 3.530 -18.682 1.00 18.82 ? 438 LYS A CD 1 ATOM 3449 C CE . LYS A 1 421 ? 27.003 2.300 -19.442 1.00 19.27 ? 438 LYS A CE 1 ATOM 3450 N NZ . LYS A 1 421 ? 25.986 1.208 -19.406 1.00 18.86 ? 438 LYS A NZ 1 ATOM 3451 N N . ILE A 1 422 ? 25.862 8.819 -17.468 1.00 18.11 ? 439 ILE A N 1 ATOM 3452 C CA . ILE A 1 422 ? 25.439 9.871 -16.535 1.00 17.76 ? 439 ILE A CA 1 ATOM 3453 C C . ILE A 1 422 ? 24.100 10.484 -16.959 1.00 17.43 ? 439 ILE A C 1 ATOM 3454 O O . ILE A 1 422 ? 23.211 10.690 -16.137 1.00 16.84 ? 439 ILE A O 1 ATOM 3455 C CB . ILE A 1 422 ? 26.520 10.959 -16.378 1.00 17.87 ? 439 ILE A CB 1 ATOM 3456 C CG1 . ILE A 1 422 ? 27.833 10.344 -15.853 1.00 17.80 ? 439 ILE A CG1 1 ATOM 3457 C CG2 . ILE A 1 422 ? 26.030 12.062 -15.453 1.00 17.87 ? 439 ILE A CG2 1 ATOM 3458 C CD1 . ILE A 1 422 ? 27.741 9.718 -14.475 1.00 17.87 ? 439 ILE A CD1 1 ATOM 3459 N N . VAL A 1 423 ? 23.968 10.758 -18.247 1.00 17.31 ? 440 VAL A N 1 ATOM 3460 C CA . VAL A 1 423 ? 22.763 11.376 -18.799 1.00 17.74 ? 440 VAL A CA 1 ATOM 3461 C C . VAL A 1 423 ? 21.479 10.551 -18.540 1.00 17.60 ? 440 VAL A C 1 ATOM 3462 O O . VAL A 1 423 ? 20.384 11.092 -18.313 1.00 15.99 ? 440 VAL A O 1 ATOM 3463 C CB . VAL A 1 423 ? 23.010 11.634 -20.305 1.00 18.87 ? 440 VAL A CB 1 ATOM 3464 C CG1 . VAL A 1 423 ? 21.734 11.774 -21.097 1.00 19.98 ? 440 VAL A CG1 1 ATOM 3465 C CG2 . VAL A 1 423 ? 23.915 12.852 -20.466 1.00 19.08 ? 440 VAL A CG2 1 ATOM 3466 N N . PHE A 1 424 ? 21.644 9.235 -18.545 1.00 16.79 ? 441 PHE A N 1 ATOM 3467 C CA . PHE A 1 424 ? 20.549 8.297 -18.305 1.00 16.01 ? 441 PHE A CA 1 ATOM 3468 C C . PHE A 1 424 ? 19.962 8.359 -16.880 1.00 16.25 ? 441 PHE A C 1 ATOM 3469 O O . PHE A 1 424 ? 18.788 8.034 -16.676 1.00 15.76 ? 441 PHE A O 1 ATOM 3470 C CB . PHE A 1 424 ? 21.070 6.899 -18.615 1.00 16.02 ? 441 PHE A CB 1 ATOM 3471 C CG . PHE A 1 424 ? 20.046 5.823 -18.508 1.00 15.60 ? 441 PHE A CG 1 ATOM 3472 C CD1 . PHE A 1 424 ? 19.152 5.605 -19.536 1.00 15.82 ? 441 PHE A CD1 1 ATOM 3473 C CD2 . PHE A 1 424 ? 19.978 5.025 -17.370 1.00 15.92 ? 441 PHE A CD2 1 ATOM 3474 C CE1 . PHE A 1 424 ? 18.203 4.602 -19.445 1.00 16.12 ? 441 PHE A CE1 1 ATOM 3475 C CE2 . PHE A 1 424 ? 19.043 4.017 -17.274 1.00 16.03 ? 441 PHE A CE2 1 ATOM 3476 C CZ . PHE A 1 424 ? 18.147 3.808 -18.311 1.00 16.29 ? 441 PHE A CZ 1 ATOM 3477 N N . LEU A 1 425 ? 20.758 8.790 -15.900 1.00 16.32 ? 442 LEU A N 1 ATOM 3478 C CA . LEU A 1 425 ? 20.351 8.677 -14.501 1.00 16.57 ? 442 LEU A CA 1 ATOM 3479 C C . LEU A 1 425 ? 19.094 9.503 -14.192 1.00 16.22 ? 442 LEU A C 1 ATOM 3480 O O . LEU A 1 425 ? 18.126 8.946 -13.684 1.00 15.98 ? 442 LEU A O 1 ATOM 3481 C CB . LEU A 1 425 ? 21.501 8.998 -13.539 1.00 17.02 ? 442 LEU A CB 1 ATOM 3482 C CG . LEU A 1 425 ? 22.809 8.212 -13.704 1.00 17.30 ? 442 LEU A CG 1 ATOM 3483 C CD1 . LEU A 1 425 ? 23.850 8.736 -12.728 1.00 17.42 ? 442 LEU A CD1 1 ATOM 3484 C CD2 . LEU A 1 425 ? 22.625 6.709 -13.528 1.00 17.46 ? 442 LEU A CD2 1 ATOM 3485 N N . PRO A 1 426 ? 19.075 10.810 -14.536 1.00 16.44 ? 443 PRO A N 1 ATOM 3486 C CA . PRO A 1 426 ? 17.814 11.528 -14.279 1.00 16.45 ? 443 PRO A CA 1 ATOM 3487 C C . PRO A 1 426 ? 16.650 11.035 -15.138 1.00 16.20 ? 443 PRO A C 1 ATOM 3488 O O . PRO A 1 426 ? 15.506 11.076 -14.684 1.00 16.91 ? 443 PRO A O 1 ATOM 3489 C CB . PRO A 1 426 ? 18.133 12.989 -14.612 1.00 16.52 ? 443 PRO A CB 1 ATOM 3490 C CG . PRO A 1 426 ? 19.450 12.983 -15.316 1.00 17.07 ? 443 PRO A CG 1 ATOM 3491 C CD . PRO A 1 426 ? 20.148 11.705 -15.000 1.00 16.74 ? 443 PRO A CD 1 ATOM 3492 N N . PHE A 1 427 ? 16.938 10.599 -16.368 1.00 16.19 ? 444 PHE A N 1 ATOM 3493 C CA . PHE A 1 427 ? 15.909 10.025 -17.225 1.00 15.64 ? 444 PHE A CA 1 ATOM 3494 C C . PHE A 1 427 ? 15.239 8.842 -16.531 1.00 15.88 ? 444 PHE A C 1 ATOM 3495 O O . PHE A 1 427 ? 14.013 8.814 -16.373 1.00 15.45 ? 444 PHE A O 1 ATOM 3496 C CB . PHE A 1 427 ? 16.476 9.560 -18.570 1.00 15.60 ? 444 PHE A CB 1 ATOM 3497 C CG . PHE A 1 427 ? 15.489 8.777 -19.378 1.00 14.64 ? 444 PHE A CG 1 ATOM 3498 C CD1 . PHE A 1 427 ? 14.520 9.429 -20.122 1.00 15.04 ? 444 PHE A CD1 1 ATOM 3499 C CD2 . PHE A 1 427 ? 15.481 7.397 -19.334 1.00 14.42 ? 444 PHE A CD2 1 ATOM 3500 C CE1 . PHE A 1 427 ? 13.575 8.713 -20.841 1.00 15.21 ? 444 PHE A CE1 1 ATOM 3501 C CE2 . PHE A 1 427 ? 14.540 6.676 -20.049 1.00 14.79 ? 444 PHE A CE2 1 ATOM 3502 C CZ . PHE A 1 427 ? 13.587 7.335 -20.796 1.00 14.87 ? 444 PHE A CZ 1 ATOM 3503 N N . ALA A 1 428 ? 16.056 7.876 -16.116 1.00 15.12 ? 445 ALA A N 1 ATOM 3504 C CA . ALA A 1 428 ? 15.549 6.662 -15.491 1.00 15.30 ? 445 ALA A CA 1 ATOM 3505 C C . ALA A 1 428 ? 14.746 6.959 -14.231 1.00 15.57 ? 445 ALA A C 1 ATOM 3506 O O . ALA A 1 428 ? 13.685 6.374 -14.014 1.00 15.27 ? 445 ALA A O 1 ATOM 3507 C CB . ALA A 1 428 ? 16.686 5.703 -15.175 1.00 15.36 ? 445 ALA A CB 1 ATOM 3508 N N . PHE A 1 429 ? 15.246 7.881 -13.416 1.00 15.67 ? 446 PHE A N 1 ATOM 3509 C CA . PHE A 1 429 ? 14.549 8.269 -12.187 1.00 16.08 ? 446 PHE A CA 1 ATOM 3510 C C . PHE A 1 429 ? 13.144 8.808 -12.493 1.00 16.30 ? 446 PHE A C 1 ATOM 3511 O O . PHE A 1 429 ? 12.167 8.444 -11.823 1.00 16.28 ? 446 PHE A O 1 ATOM 3512 C CB . PHE A 1 429 ? 15.359 9.309 -11.384 1.00 16.54 ? 446 PHE A CB 1 ATOM 3513 C CG . PHE A 1 429 ? 15.313 9.130 -9.873 1.00 16.81 ? 446 PHE A CG 1 ATOM 3514 C CD1 . PHE A 1 429 ? 14.422 8.260 -9.239 1.00 17.24 ? 446 PHE A CD1 1 ATOM 3515 C CD2 . PHE A 1 429 ? 16.170 9.885 -9.075 1.00 17.54 ? 446 PHE A CD2 1 ATOM 3516 C CE1 . PHE A 1 429 ? 14.425 8.121 -7.851 1.00 17.65 ? 446 PHE A CE1 1 ATOM 3517 C CE2 . PHE A 1 429 ? 16.163 9.759 -7.695 1.00 17.71 ? 446 PHE A CE2 1 ATOM 3518 C CZ . PHE A 1 429 ? 15.295 8.875 -7.081 1.00 17.72 ? 446 PHE A CZ 1 ATOM 3519 N N . THR A 1 430 ? 13.031 9.644 -13.527 1.00 16.03 ? 447 THR A N 1 ATOM 3520 C CA . THR A 1 430 ? 11.748 10.256 -13.867 1.00 16.44 ? 447 THR A CA 1 ATOM 3521 C C . THR A 1 430 ? 10.714 9.275 -14.396 1.00 16.26 ? 447 THR A C 1 ATOM 3522 O O . THR A 1 430 ? 9.526 9.496 -14.195 1.00 16.04 ? 447 THR A O 1 ATOM 3523 C CB . THR A 1 430 ? 11.870 11.435 -14.867 1.00 16.44 ? 447 THR A CB 1 ATOM 3524 O OG1 . THR A 1 430 ? 12.411 10.985 -16.123 1.00 17.06 ? 447 THR A OG1 1 ATOM 3525 C CG2 . THR A 1 430 ? 12.730 12.535 -14.286 1.00 17.05 ? 447 THR A CG2 1 ATOM 3526 N N . MET A 1 431 ? 11.150 8.201 -15.057 1.00 16.15 ? 448 MET A N 1 ATOM 3527 C CA . MET A 1 431 ? 10.213 7.212 -15.589 1.00 16.61 ? 448 MET A CA 1 ATOM 3528 C C . MET A 1 431 ? 9.359 6.615 -14.466 1.00 17.52 ? 448 MET A C 1 ATOM 3529 O O . MET A 1 431 ? 8.151 6.429 -14.638 1.00 17.86 ? 448 MET A O 1 ATOM 3530 C CB . MET A 1 431 ? 10.940 6.087 -16.348 1.00 16.48 ? 448 MET A CB 1 ATOM 3531 C CG . MET A 1 431 ? 11.609 6.502 -17.661 1.00 16.28 ? 448 MET A CG 1 ATOM 3532 S SD . MET A 1 431 ? 10.479 7.266 -18.853 1.00 17.07 ? 448 MET A SD 1 ATOM 3533 C CE . MET A 1 431 ? 10.799 9.012 -18.580 1.00 17.08 ? 448 MET A CE 1 ATOM 3534 N N . ASP A 1 432 ? 9.974 6.340 -13.315 1.00 17.27 ? 449 ASP A N 1 ATOM 3535 C CA . ASP A 1 432 ? 9.222 5.812 -12.181 1.00 17.47 ? 449 ASP A CA 1 ATOM 3536 C C . ASP A 1 432 ? 8.686 6.876 -11.248 1.00 17.51 ? 449 ASP A C 1 ATOM 3537 O O . ASP A 1 432 ? 7.596 6.699 -10.708 1.00 17.57 ? 449 ASP A O 1 ATOM 3538 C CB . ASP A 1 432 ? 10.015 4.738 -11.430 1.00 17.76 ? 449 ASP A CB 1 ATOM 3539 C CG . ASP A 1 432 ? 9.945 3.388 -12.119 1.00 18.21 ? 449 ASP A CG 1 ATOM 3540 O OD1 . ASP A 1 432 ? 9.494 3.318 -13.285 1.00 19.15 ? 449 ASP A OD1 1 ATOM 3541 O OD2 . ASP A 1 432 ? 10.340 2.386 -11.506 1.00 18.54 ? 449 ASP A OD2 1 ATOM 3542 N N . LYS A 1 433 ? 9.392 7.990 -11.084 1.00 17.65 ? 450 LYS A N 1 ATOM 3543 C CA . LYS A 1 433 ? 8.835 9.110 -10.329 1.00 17.17 ? 450 LYS A CA 1 ATOM 3544 C C . LYS A 1 433 ? 7.474 9.513 -10.905 1.00 17.14 ? 450 LYS A C 1 ATOM 3545 O O . LYS A 1 433 ? 6.523 9.715 -10.159 1.00 16.48 ? 450 LYS A O 1 ATOM 3546 C CB . LYS A 1 433 ? 9.767 10.316 -10.315 1.00 18.12 ? 450 LYS A CB 1 ATOM 3547 C CG . LYS A 1 433 ? 10.909 10.206 -9.329 1.00 18.78 ? 450 LYS A CG 1 ATOM 3548 C CD . LYS A 1 433 ? 11.734 11.485 -9.305 1.00 20.20 ? 450 LYS A CD 1 ATOM 3549 C CE . LYS A 1 433 ? 12.693 11.479 -8.126 1.00 20.98 ? 450 LYS A CE 1 ATOM 3550 N NZ . LYS A 1 433 ? 12.004 11.848 -6.851 1.00 21.45 ? 450 LYS A NZ 1 ATOM 3551 N N . TYR A 1 434 ? 7.385 9.584 -12.230 1.00 16.67 ? 451 TYR A N 1 ATOM 3552 C CA . TYR A 1 434 ? 6.121 9.889 -12.892 1.00 16.59 ? 451 TYR A CA 1 ATOM 3553 C C . TYR A 1 434 ? 5.046 8.849 -12.587 1.00 16.55 ? 451 TYR A C 1 ATOM 3554 O O . TYR A 1 434 ? 3.947 9.197 -12.141 1.00 17.09 ? 451 TYR A O 1 ATOM 3555 C CB . TYR A 1 434 ? 6.302 9.982 -14.400 1.00 16.50 ? 451 TYR A CB 1 ATOM 3556 C CG . TYR A 1 434 ? 5.005 10.269 -15.119 1.00 16.65 ? 451 TYR A CG 1 ATOM 3557 C CD1 . TYR A 1 434 ? 4.335 11.485 -14.926 1.00 16.86 ? 451 TYR A CD1 1 ATOM 3558 C CD2 . TYR A 1 434 ? 4.447 9.342 -15.989 1.00 16.16 ? 451 TYR A CD2 1 ATOM 3559 C CE1 . TYR A 1 434 ? 3.151 11.765 -15.596 1.00 16.68 ? 451 TYR A CE1 1 ATOM 3560 C CE2 . TYR A 1 434 ? 3.262 9.606 -16.656 1.00 16.58 ? 451 TYR A CE2 1 ATOM 3561 C CZ . TYR A 1 434 ? 2.617 10.818 -16.458 1.00 17.00 ? 451 TYR A CZ 1 ATOM 3562 O OH . TYR A 1 434 ? 1.453 11.072 -17.132 1.00 17.68 ? 451 TYR A OH 1 ATOM 3563 N N . ARG A 1 435 ? 5.358 7.581 -12.841 1.00 15.72 ? 452 ARG A N 1 ATOM 3564 C CA . ARG A 1 435 ? 4.373 6.518 -12.634 1.00 16.12 ? 452 ARG A CA 1 ATOM 3565 C C . ARG A 1 435 ? 3.971 6.361 -11.167 1.00 15.99 ? 452 ARG A C 1 ATOM 3566 O O . ARG A 1 435 ? 2.776 6.213 -10.859 1.00 15.83 ? 452 ARG A O 1 ATOM 3567 C CB . ARG A 1 435 ? 4.855 5.206 -13.246 1.00 15.74 ? 452 ARG A CB 1 ATOM 3568 C CG . ARG A 1 435 ? 4.832 5.271 -14.765 1.00 15.73 ? 452 ARG A CG 1 ATOM 3569 C CD . ARG A 1 435 ? 5.128 3.935 -15.419 1.00 15.97 ? 452 ARG A CD 1 ATOM 3570 N NE . ARG A 1 435 ? 6.522 3.546 -15.247 1.00 15.96 ? 452 ARG A NE 1 ATOM 3571 C CZ . ARG A 1 435 ? 7.081 2.459 -15.775 1.00 15.80 ? 452 ARG A CZ 1 ATOM 3572 N NH1 . ARG A 1 435 ? 6.376 1.627 -16.523 1.00 15.78 ? 452 ARG A NH1 1 ATOM 3573 N NH2 . ARG A 1 435 ? 8.367 2.206 -15.548 1.00 16.22 ? 452 ARG A NH2 1 ATOM 3574 N N . TRP A 1 436 ? 4.941 6.459 -10.263 1.00 16.26 ? 453 TRP A N 1 ATOM 3575 C CA . TRP A 1 436 ? 4.637 6.439 -8.824 1.00 17.39 ? 453 TRP A CA 1 ATOM 3576 C C . TRP A 1 436 ? 3.642 7.525 -8.457 1.00 17.73 ? 453 TRP A C 1 ATOM 3577 O O . TRP A 1 436 ? 2.711 7.280 -7.670 1.00 17.22 ? 453 TRP A O 1 ATOM 3578 C CB . TRP A 1 436 ? 5.872 6.654 -7.951 1.00 17.35 ? 453 TRP A CB 1 ATOM 3579 C CG . TRP A 1 436 ? 6.932 5.630 -8.019 1.00 17.77 ? 453 TRP A CG 1 ATOM 3580 C CD1 . TRP A 1 436 ? 6.826 4.337 -8.444 1.00 18.03 ? 453 TRP A CD1 1 ATOM 3581 C CD2 . TRP A 1 436 ? 8.282 5.808 -7.594 1.00 18.04 ? 453 TRP A CD2 1 ATOM 3582 N NE1 . TRP A 1 436 ? 8.034 3.709 -8.328 1.00 18.05 ? 453 TRP A NE1 1 ATOM 3583 C CE2 . TRP A 1 436 ? 8.949 4.590 -7.813 1.00 17.95 ? 453 TRP A CE2 1 ATOM 3584 C CE3 . TRP A 1 436 ? 9.001 6.903 -7.076 1.00 18.57 ? 453 TRP A CE3 1 ATOM 3585 C CZ2 . TRP A 1 436 ? 10.305 4.413 -7.517 1.00 18.67 ? 453 TRP A CZ2 1 ATOM 3586 C CZ3 . TRP A 1 436 ? 10.349 6.737 -6.781 1.00 18.94 ? 453 TRP A CZ3 1 ATOM 3587 C CH2 . TRP A 1 436 ? 10.991 5.491 -7.005 1.00 18.94 ? 453 TRP A CH2 1 ATOM 3588 N N . SER A 1 437 ? 3.850 8.728 -9.001 1.00 17.41 ? 454 SER A N 1 ATOM 3589 C CA . SER A 1 437 ? 2.945 9.845 -8.717 1.00 18.26 ? 454 SER A CA 1 ATOM 3590 C C . SER A 1 437 ? 1.511 9.565 -9.188 1.00 18.26 ? 454 SER A C 1 ATOM 3591 O O . SER A 1 437 ? 0.558 9.916 -8.480 1.00 19.32 ? 454 SER A O 1 ATOM 3592 C CB . SER A 1 437 ? 3.494 11.191 -9.252 1.00 18.33 ? 454 SER A CB 1 ATOM 3593 O OG . SER A 1 437 ? 3.372 11.313 -10.662 1.00 19.31 ? 454 SER A OG 1 ATOM 3594 N N . LEU A 1 438 ? 1.355 8.895 -10.337 1.00 17.62 ? 455 LEU A N 1 ATOM 3595 C CA . LEU A 1 438 ? 0.030 8.483 -10.812 1.00 17.58 ? 455 LEU A CA 1 ATOM 3596 C C . LEU A 1 438 ? -0.543 7.355 -9.961 1.00 17.69 ? 455 LEU A C 1 ATOM 3597 O O . LEU A 1 438 ? -1.705 7.412 -9.567 1.00 17.17 ? 455 LEU A O 1 ATOM 3598 C CB . LEU A 1 438 ? 0.052 8.033 -12.279 1.00 17.60 ? 455 LEU A CB 1 ATOM 3599 C CG . LEU A 1 438 ? 0.609 8.992 -13.327 1.00 18.26 ? 455 LEU A CG 1 ATOM 3600 C CD1 . LEU A 1 438 ? 0.204 8.545 -14.730 1.00 18.75 ? 455 LEU A CD1 1 ATOM 3601 C CD2 . LEU A 1 438 ? 0.176 10.420 -13.081 1.00 19.34 ? 455 LEU A CD2 1 ATOM 3602 N N . PHE A 1 439 ? 0.273 6.334 -9.701 1.00 17.34 ? 456 PHE A N 1 ATOM 3603 C CA . PHE A 1 439 ? -0.100 5.216 -8.843 1.00 17.82 ? 456 PHE A CA 1 ATOM 3604 C C . PHE A 1 439 ? -0.594 5.668 -7.471 1.00 18.35 ? 456 PHE A C 1 ATOM 3605 O O . PHE A 1 439 ? -1.571 5.132 -6.958 1.00 18.13 ? 456 PHE A O 1 ATOM 3606 C CB . PHE A 1 439 ? 1.080 4.243 -8.656 1.00 17.83 ? 456 PHE A CB 1 ATOM 3607 C CG . PHE A 1 439 ? 1.460 3.453 -9.892 1.00 17.99 ? 456 PHE A CG 1 ATOM 3608 C CD1 . PHE A 1 439 ? 0.616 3.330 -11.003 1.00 18.72 ? 456 PHE A CD1 1 ATOM 3609 C CD2 . PHE A 1 439 ? 2.679 2.793 -9.923 1.00 18.41 ? 456 PHE A CD2 1 ATOM 3610 C CE1 . PHE A 1 439 ? 1.007 2.587 -12.123 1.00 18.57 ? 456 PHE A CE1 1 ATOM 3611 C CE2 . PHE A 1 439 ? 3.061 2.041 -11.029 1.00 18.77 ? 456 PHE A CE2 1 ATOM 3612 C CZ . PHE A 1 439 ? 2.221 1.934 -12.126 1.00 18.30 ? 456 PHE A CZ 1 ATOM 3613 N N . ARG A 1 440 ? 0.082 6.659 -6.906 1.00 18.55 ? 457 ARG A N 1 ATOM 3614 C CA . ARG A 1 440 ? -0.240 7.176 -5.578 1.00 19.72 ? 457 ARG A CA 1 ATOM 3615 C C . ARG A 1 440 ? -1.428 8.152 -5.558 1.00 20.56 ? 457 ARG A C 1 ATOM 3616 O O . ARG A 1 440 ? -1.853 8.575 -4.487 1.00 20.36 ? 457 ARG A O 1 ATOM 3617 C CB . ARG A 1 440 ? 1.003 7.813 -4.948 1.00 19.64 ? 457 ARG A CB 1 ATOM 3618 C CG . ARG A 1 440 ? 2.050 6.791 -4.526 1.00 20.35 ? 457 ARG A CG 1 ATOM 3619 C CD . ARG A 1 440 ? 3.391 7.442 -4.246 1.00 20.43 ? 457 ARG A CD 1 ATOM 3620 N NE . ARG A 1 440 ? 4.338 6.505 -3.635 1.00 20.40 ? 457 ARG A NE 1 ATOM 3621 C CZ . ARG A 1 440 ? 5.668 6.627 -3.652 1.00 20.34 ? 457 ARG A CZ 1 ATOM 3622 N NH1 . ARG A 1 440 ? 6.270 7.650 -4.264 1.00 20.52 ? 457 ARG A NH1 1 ATOM 3623 N NH2 . ARG A 1 440 ? 6.414 5.703 -3.046 1.00 20.69 ? 457 ARG A NH2 1 ATOM 3624 N N . GLY A 1 441 ? -1.971 8.499 -6.722 1.00 21.17 ? 458 GLY A N 1 ATOM 3625 C CA . GLY A 1 441 ? -3.127 9.396 -6.803 1.00 22.67 ? 458 GLY A CA 1 ATOM 3626 C C . GLY A 1 441 ? -2.767 10.844 -6.547 1.00 23.62 ? 458 GLY A C 1 ATOM 3627 O O . GLY A 1 441 ? -3.619 11.629 -6.131 1.00 24.35 ? 458 GLY A O 1 ATOM 3628 N N . GLU A 1 442 ? -1.510 11.206 -6.795 1.00 23.32 ? 459 GLU A N 1 ATOM 3629 C CA . GLU A 1 442 ? -1.020 12.531 -6.454 1.00 24.22 ? 459 GLU A CA 1 ATOM 3630 C C . GLU A 1 442 ? -1.248 13.549 -7.551 1.00 24.76 ? 459 GLU A C 1 ATOM 3631 O O . GLU A 1 442 ? -1.094 14.737 -7.306 1.00 24.10 ? 459 GLU A O 1 ATOM 3632 C CB . GLU A 1 442 ? 0.461 12.480 -6.103 1.00 24.74 ? 459 GLU A CB 1 ATOM 3633 C CG . GLU A 1 442 ? 0.738 11.656 -4.869 1.00 26.02 ? 459 GLU A CG 1 ATOM 3634 C CD . GLU A 1 442 ? 2.200 11.334 -4.682 1.00 27.51 ? 459 GLU A CD 1 ATOM 3635 O OE1 . GLU A 1 442 ? 2.994 11.486 -5.636 1.00 26.98 ? 459 GLU A OE1 1 ATOM 3636 O OE2 . GLU A 1 442 ? 2.553 10.921 -3.563 1.00 29.11 ? 459 GLU A OE2 1 ATOM 3637 N N . VAL A 1 443 ? -1.617 13.093 -8.747 1.00 25.32 ? 460 VAL A N 1 ATOM 3638 C CA . VAL A 1 443 ? -1.864 13.974 -9.884 1.00 26.98 ? 460 VAL A CA 1 ATOM 3639 C C . VAL A 1 443 ? -3.261 13.702 -10.429 1.00 28.06 ? 460 VAL A C 1 ATOM 3640 O O . VAL A 1 443 ? -3.584 12.572 -10.773 1.00 27.81 ? 460 VAL A O 1 ATOM 3641 C CB . VAL A 1 443 ? -0.831 13.754 -11.011 1.00 26.44 ? 460 VAL A CB 1 ATOM 3642 C CG1 . VAL A 1 443 ? -0.957 14.835 -12.072 1.00 26.42 ? 460 VAL A CG1 1 ATOM 3643 C CG2 . VAL A 1 443 ? 0.584 13.740 -10.451 1.00 26.81 ? 460 VAL A CG2 1 ATOM 3644 N N . ASP A 1 444 ? -4.073 14.751 -10.518 1.00 30.42 ? 461 ASP A N 1 ATOM 3645 C CA . ASP A 1 444 ? -5.413 14.666 -11.113 1.00 33.17 ? 461 ASP A CA 1 ATOM 3646 C C . ASP A 1 444 ? -5.257 14.341 -12.602 1.00 31.58 ? 461 ASP A C 1 ATOM 3647 O O . ASP A 1 444 ? -4.347 14.855 -13.252 1.00 27.71 ? 461 ASP A O 1 ATOM 3648 C CB . ASP A 1 444 ? -6.150 16.001 -10.863 1.00 37.38 ? 461 ASP A CB 1 ATOM 3649 C CG . ASP A 1 444 ? -7.407 16.199 -11.719 1.00 41.70 ? 461 ASP A CG 1 ATOM 3650 O OD1 . ASP A 1 444 ? -7.972 15.244 -12.300 1.00 46.03 ? 461 ASP A OD1 1 ATOM 3651 O OD2 . ASP A 1 444 ? -7.845 17.365 -11.797 1.00 48.04 ? 461 ASP A OD2 1 ATOM 3652 N N . LYS A 1 445 ? -6.140 13.485 -13.124 1.00 32.13 ? 462 LYS A N 1 ATOM 3653 C CA . LYS A 1 445 ? -6.129 13.068 -14.547 1.00 33.11 ? 462 LYS A CA 1 ATOM 3654 C C . LYS A 1 445 ? -6.057 14.228 -15.549 1.00 30.69 ? 462 LYS A C 1 ATOM 3655 O O . LYS A 1 445 ? -5.433 14.098 -16.606 1.00 30.23 ? 462 LYS A O 1 ATOM 3656 C CB . LYS A 1 445 ? -7.320 12.140 -14.853 1.00 36.56 ? 462 LYS A CB 1 ATOM 3657 C CG . LYS A 1 445 ? -7.115 10.738 -14.287 1.00 40.74 ? 462 LYS A CG 1 ATOM 3658 C CD . LYS A 1 445 ? -8.406 9.960 -14.012 1.00 45.00 ? 462 LYS A CD 1 ATOM 3659 C CE . LYS A 1 445 ? -8.728 8.933 -15.094 1.00 48.24 ? 462 LYS A CE 1 ATOM 3660 N NZ . LYS A 1 445 ? -9.332 7.683 -14.534 1.00 49.88 ? 462 LYS A NZ 1 ATOM 3661 N N . ALA A 1 446 ? -6.671 15.358 -15.201 1.00 28.91 ? 463 ALA A N 1 ATOM 3662 C CA . ALA A 1 446 ? -6.563 16.595 -15.983 1.00 26.99 ? 463 ALA A CA 1 ATOM 3663 C C . ALA A 1 446 ? -5.128 17.130 -16.169 1.00 24.92 ? 463 ALA A C 1 ATOM 3664 O O . ALA A 1 446 ? -4.891 17.895 -17.093 1.00 24.27 ? 463 ALA A O 1 ATOM 3665 C CB . ALA A 1 446 ? -7.427 17.679 -15.355 1.00 27.75 ? 463 ALA A CB 1 ATOM 3666 N N . ASN A 1 447 ? -4.198 16.758 -15.286 1.00 22.96 ? 464 ASN A N 1 ATOM 3667 C CA . ASN A 1 447 ? -2.817 17.265 -15.309 1.00 22.22 ? 464 ASN A CA 1 ATOM 3668 C C . ASN A 1 447 ? -1.737 16.205 -15.600 1.00 20.67 ? 464 ASN A C 1 ATOM 3669 O O . ASN A 1 447 ? -0.544 16.455 -15.398 1.00 19.17 ? 464 ASN A O 1 ATOM 3670 C CB . ASN A 1 447 ? -2.515 17.948 -13.976 1.00 23.23 ? 464 ASN A CB 1 ATOM 3671 C CG . ASN A 1 447 ? -3.519 19.042 -13.651 1.00 25.03 ? 464 ASN A CG 1 ATOM 3672 O OD1 . ASN A 1 447 ? -4.167 19.029 -12.598 1.00 27.27 ? 464 ASN A OD1 1 ATOM 3673 N ND2 . ASN A 1 447 ? -3.673 19.969 -14.566 1.00 24.10 ? 464 ASN A ND2 1 ATOM 3674 N N . TRP A 1 448 ? -2.149 15.043 -16.096 1.00 19.87 ? 465 TRP A N 1 ATOM 3675 C CA . TRP A 1 448 ? -1.216 13.925 -16.285 1.00 19.55 ? 465 TRP A CA 1 ATOM 3676 C C . TRP A 1 448 ? -0.123 14.199 -17.312 1.00 19.31 ? 465 TRP A C 1 ATOM 3677 O O . TRP A 1 448 ? 1.023 13.809 -17.096 1.00 18.85 ? 465 TRP A O 1 ATOM 3678 C CB . TRP A 1 448 ? -1.961 12.632 -16.626 1.00 19.65 ? 465 TRP A CB 1 ATOM 3679 C CG . TRP A 1 448 ? -2.527 11.892 -15.451 1.00 20.27 ? 465 TRP A CG 1 ATOM 3680 C CD1 . TRP A 1 448 ? -2.722 12.372 -14.184 1.00 21.59 ? 465 TRP A CD1 1 ATOM 3681 C CD2 . TRP A 1 448 ? -2.993 10.542 -15.439 1.00 20.22 ? 465 TRP A CD2 1 ATOM 3682 N NE1 . TRP A 1 448 ? -3.269 11.399 -13.381 1.00 21.15 ? 465 TRP A NE1 1 ATOM 3683 C CE2 . TRP A 1 448 ? -3.449 10.266 -14.127 1.00 21.19 ? 465 TRP A CE2 1 ATOM 3684 C CE3 . TRP A 1 448 ? -3.055 9.532 -16.400 1.00 20.41 ? 465 TRP A CE3 1 ATOM 3685 C CZ2 . TRP A 1 448 ? -3.964 9.011 -13.754 1.00 21.18 ? 465 TRP A CZ2 1 ATOM 3686 C CZ3 . TRP A 1 448 ? -3.567 8.284 -16.029 1.00 20.79 ? 465 TRP A CZ3 1 ATOM 3687 C CH2 . TRP A 1 448 ? -4.014 8.040 -14.717 1.00 20.55 ? 465 TRP A CH2 1 ATOM 3688 N N . ASN A 1 449 ? -0.437 14.874 -18.417 1.00 18.84 ? 466 ASN A N 1 ATOM 3689 C CA . ASN A 1 449 ? 0.612 15.083 -19.416 1.00 18.49 ? 466 ASN A CA 1 ATOM 3690 C C . ASN A 1 449 ? 1.644 16.136 -19.044 1.00 19.21 ? 466 ASN A C 1 ATOM 3691 O O . ASN A 1 449 ? 2.856 15.924 -19.213 1.00 18.69 ? 466 ASN A O 1 ATOM 3692 C CB . ASN A 1 449 ? 0.072 15.346 -20.807 1.00 17.48 ? 466 ASN A CB 1 ATOM 3693 C CG . ASN A 1 449 ? 1.096 14.992 -21.874 1.00 17.51 ? 466 ASN A CG 1 ATOM 3694 O OD1 . ASN A 1 449 ? 1.718 13.930 -21.814 1.00 16.80 ? 466 ASN A OD1 1 ATOM 3695 N ND2 . ASN A 1 449 ? 1.287 15.871 -22.835 1.00 17.18 ? 466 ASN A ND2 1 ATOM 3696 N N . CYS A 1 450 ? 1.189 17.266 -18.522 1.00 19.66 ? 467 CYS A N 1 ATOM 3697 C CA . CYS A 1 450 ? 2.140 18.289 -18.105 1.00 20.79 ? 467 CYS A CA 1 ATOM 3698 C C . CYS A 1 450 ? 2.915 17.866 -16.850 1.00 19.47 ? 467 CYS A C 1 ATOM 3699 O O . CYS A 1 450 ? 4.060 18.271 -16.680 1.00 19.62 ? 467 CYS A O 1 ATOM 3700 C CB . CYS A 1 450 ? 1.463 19.652 -17.999 1.00 22.24 ? 467 CYS A CB 1 ATOM 3701 S SG . CYS A 1 450 ? 0.961 20.303 -19.633 1.00 25.60 ? 467 CYS A SG 1 ATOM 3702 N N . ALA A 1 451 ? 2.335 16.998 -16.024 1.00 18.39 ? 468 ALA A N 1 ATOM 3703 C CA . ALA A 1 451 ? 3.097 16.377 -14.930 1.00 18.73 ? 468 ALA A CA 1 ATOM 3704 C C . ALA A 1 451 ? 4.315 15.584 -15.441 1.00 18.12 ? 468 ALA A C 1 ATOM 3705 O O . ALA A 1 451 ? 5.389 15.613 -14.823 1.00 18.05 ? 468 ALA A O 1 ATOM 3706 C CB . ALA A 1 451 ? 2.201 15.488 -14.083 1.00 19.27 ? 468 ALA A CB 1 ATOM 3707 N N . PHE A 1 452 ? 4.148 14.888 -16.562 1.00 17.24 ? 469 PHE A N 1 ATOM 3708 C CA . PHE A 1 452 ? 5.253 14.144 -17.182 1.00 17.08 ? 469 PHE A CA 1 ATOM 3709 C C . PHE A 1 452 ? 6.352 15.102 -17.618 1.00 16.82 ? 469 PHE A C 1 ATOM 3710 O O . PHE A 1 452 ? 7.501 14.976 -17.179 1.00 17.18 ? 469 PHE A O 1 ATOM 3711 C CB . PHE A 1 452 ? 4.759 13.321 -18.373 1.00 16.64 ? 469 PHE A CB 1 ATOM 3712 C CG . PHE A 1 452 ? 5.834 12.505 -19.047 1.00 16.25 ? 469 PHE A CG 1 ATOM 3713 C CD1 . PHE A 1 452 ? 6.369 11.385 -18.425 1.00 16.45 ? 469 PHE A CD1 1 ATOM 3714 C CD2 . PHE A 1 452 ? 6.289 12.846 -20.315 1.00 16.08 ? 469 PHE A CD2 1 ATOM 3715 C CE1 . PHE A 1 452 ? 7.355 10.622 -19.041 1.00 16.60 ? 469 PHE A CE1 1 ATOM 3716 C CE2 . PHE A 1 452 ? 7.277 12.089 -20.943 1.00 16.17 ? 469 PHE A CE2 1 ATOM 3717 C CZ . PHE A 1 452 ? 7.809 10.975 -20.307 1.00 16.30 ? 469 PHE A CZ 1 ATOM 3718 N N . TRP A 1 453 ? 6.000 16.086 -18.437 1.00 17.26 ? 470 TRP A N 1 ATOM 3719 C CA . TRP A 1 453 ? 7.016 17.009 -18.961 1.00 17.37 ? 470 TRP A CA 1 ATOM 3720 C C . TRP A 1 453 ? 7.640 17.894 -17.883 1.00 18.35 ? 470 TRP A C 1 ATOM 3721 O O . TRP A 1 453 ? 8.818 18.251 -17.977 1.00 17.40 ? 470 TRP A O 1 ATOM 3722 C CB . TRP A 1 453 ? 6.475 17.819 -20.141 1.00 17.30 ? 470 TRP A CB 1 ATOM 3723 C CG . TRP A 1 453 ? 6.224 16.941 -21.322 1.00 16.73 ? 470 TRP A CG 1 ATOM 3724 C CD1 . TRP A 1 453 ? 5.025 16.683 -21.900 1.00 16.72 ? 470 TRP A CD1 1 ATOM 3725 C CD2 . TRP A 1 453 ? 7.194 16.152 -22.027 1.00 16.29 ? 470 TRP A CD2 1 ATOM 3726 N NE1 . TRP A 1 453 ? 5.183 15.795 -22.942 1.00 16.42 ? 470 TRP A NE1 1 ATOM 3727 C CE2 . TRP A 1 453 ? 6.504 15.456 -23.043 1.00 16.29 ? 470 TRP A CE2 1 ATOM 3728 C CE3 . TRP A 1 453 ? 8.577 15.967 -21.898 1.00 15.97 ? 470 TRP A CE3 1 ATOM 3729 C CZ2 . TRP A 1 453 ? 7.150 14.593 -23.936 1.00 16.10 ? 470 TRP A CZ2 1 ATOM 3730 C CZ3 . TRP A 1 453 ? 9.227 15.112 -22.795 1.00 16.31 ? 470 TRP A CZ3 1 ATOM 3731 C CH2 . TRP A 1 453 ? 8.505 14.430 -23.795 1.00 16.46 ? 470 TRP A CH2 1 ATOM 3732 N N . LYS A 1 454 ? 6.881 18.206 -16.835 1.00 19.41 ? 471 LYS A N 1 ATOM 3733 C CA . LYS A 1 454 ? 7.435 18.950 -15.702 1.00 22.13 ? 471 LYS A CA 1 ATOM 3734 C C . LYS A 1 454 ? 8.571 18.185 -15.013 1.00 19.99 ? 471 LYS A C 1 ATOM 3735 O O . LYS A 1 454 ? 9.609 18.767 -14.702 1.00 18.32 ? 471 LYS A O 1 ATOM 3736 C CB . LYS A 1 454 ? 6.329 19.310 -14.714 1.00 26.68 ? 471 LYS A CB 1 ATOM 3737 C CG . LYS A 1 454 ? 6.822 20.038 -13.472 1.00 32.90 ? 471 LYS A CG 1 ATOM 3738 C CD . LYS A 1 454 ? 5.849 21.082 -12.915 1.00 36.87 ? 471 LYS A CD 1 ATOM 3739 C CE . LYS A 1 454 ? 4.420 20.580 -12.760 1.00 40.36 ? 471 LYS A CE 1 ATOM 3740 N NZ . LYS A 1 454 ? 3.509 21.092 -13.835 1.00 44.56 ? 471 LYS A NZ 1 ATOM 3741 N N . LEU A 1 455 ? 8.371 16.887 -14.794 1.00 19.09 ? 472 LEU A N 1 ATOM 3742 C CA . LEU A 1 455 ? 9.423 16.030 -14.253 1.00 19.52 ? 472 LEU A CA 1 ATOM 3743 C C . LEU A 1 455 ? 10.642 15.922 -15.181 1.00 18.32 ? 472 LEU A C 1 ATOM 3744 O O . LEU A 1 455 ? 11.787 15.921 -14.714 1.00 17.54 ? 472 LEU A O 1 ATOM 3745 C CB . LEU A 1 455 ? 8.895 14.616 -13.938 1.00 20.11 ? 472 LEU A CB 1 ATOM 3746 C CG . LEU A 1 455 ? 8.162 14.404 -12.615 1.00 21.48 ? 472 LEU A CG 1 ATOM 3747 C CD1 . LEU A 1 455 ? 7.529 13.017 -12.588 1.00 21.78 ? 472 LEU A CD1 1 ATOM 3748 C CD2 . LEU A 1 455 ? 9.105 14.570 -11.426 1.00 21.84 ? 472 LEU A CD2 1 ATOM 3749 N N . ARG A 1 456 ? 10.388 15.789 -16.480 1.00 17.64 ? 473 ARG A N 1 ATOM 3750 C CA . ARG A 1 456 ? 11.461 15.685 -17.464 1.00 17.75 ? 473 ARG A CA 1 ATOM 3751 C C . ARG A 1 456 ? 12.303 16.979 -17.499 1.00 18.01 ? 473 ARG A C 1 ATOM 3752 O O . ARG A 1 456 ? 13.519 16.936 -17.632 1.00 17.58 ? 473 ARG A O 1 ATOM 3753 C CB . ARG A 1 456 ? 10.909 15.344 -18.863 1.00 17.55 ? 473 ARG A CB 1 ATOM 3754 C CG . ARG A 1 456 ? 10.111 14.044 -18.961 1.00 17.60 ? 473 ARG A CG 1 ATOM 3755 C CD . ARG A 1 456 ? 10.896 12.777 -18.623 1.00 17.39 ? 473 ARG A CD 1 ATOM 3756 N NE . ARG A 1 456 ? 12.028 12.688 -19.535 1.00 17.37 ? 473 ARG A NE 1 ATOM 3757 C CZ . ARG A 1 456 ? 13.312 12.819 -19.215 1.00 17.68 ? 473 ARG A CZ 1 ATOM 3758 N NH1 . ARG A 1 456 ? 13.726 12.940 -17.942 1.00 17.64 ? 473 ARG A NH1 1 ATOM 3759 N NH2 . ARG A 1 456 ? 14.208 12.806 -20.200 1.00 17.93 ? 473 ARG A NH2 1 ATOM 3760 N N . ASP A 1 457 ? 11.634 18.121 -17.363 1.00 18.32 ? 474 ASP A N 1 ATOM 3761 C CA . ASP A 1 457 ? 12.291 19.430 -17.239 1.00 19.62 ? 474 ASP A CA 1 ATOM 3762 C C . ASP A 1 457 ? 13.110 19.508 -15.940 1.00 19.42 ? 474 ASP A C 1 ATOM 3763 O O . ASP A 1 457 ? 14.336 19.707 -15.963 1.00 19.44 ? 474 ASP A O 1 ATOM 3764 C CB . ASP A 1 457 ? 11.192 20.519 -17.306 1.00 21.37 ? 474 ASP A CB 1 ATOM 3765 C CG . ASP A 1 457 ? 11.702 21.936 -17.085 1.00 23.63 ? 474 ASP A CG 1 ATOM 3766 O OD1 . ASP A 1 457 ? 12.885 22.168 -16.750 1.00 26.06 ? 474 ASP A OD1 1 ATOM 3767 O OD2 . ASP A 1 457 ? 10.867 22.843 -17.235 1.00 25.35 ? 474 ASP A OD2 1 ATOM 3768 N N . GLU A 1 458 ? 12.429 19.331 -14.816 1.00 19.84 ? 475 GLU A N 1 ATOM 3769 C CA . GLU A 1 458 ? 13.047 19.413 -13.495 1.00 21.86 ? 475 GLU A CA 1 ATOM 3770 C C . GLU A 1 458 ? 14.342 18.593 -13.350 1.00 20.65 ? 475 GLU A C 1 ATOM 3771 O O . GLU A 1 458 ? 15.357 19.098 -12.855 1.00 19.33 ? 475 GLU A O 1 ATOM 3772 C CB . GLU A 1 458 ? 12.018 18.964 -12.452 1.00 25.19 ? 475 GLU A CB 1 ATOM 3773 C CG . GLU A 1 458 ? 12.521 18.868 -11.023 1.00 29.51 ? 475 GLU A CG 1 ATOM 3774 C CD . GLU A 1 458 ? 11.419 18.484 -10.041 1.00 33.98 ? 475 GLU A CD 1 ATOM 3775 O OE1 . GLU A 1 458 ? 10.310 18.068 -10.482 1.00 36.06 ? 475 GLU A OE1 1 ATOM 3776 O OE2 . GLU A 1 458 ? 11.689 18.574 -8.824 1.00 35.88 ? 475 GLU A OE2 1 ATOM 3777 N N . TYR A 1 459 ? 14.302 17.336 -13.783 1.00 18.76 ? 476 TYR A N 1 ATOM 3778 C CA . TYR A 1 459 ? 15.428 16.421 -13.582 1.00 18.63 ? 476 TYR A CA 1 ATOM 3779 C C . TYR A 1 459 ? 16.439 16.407 -14.728 1.00 17.78 ? 476 TYR A C 1 ATOM 3780 O O . TYR A 1 459 ? 17.640 16.395 -14.485 1.00 17.55 ? 476 TYR A O 1 ATOM 3781 C CB . TYR A 1 459 ? 14.923 14.997 -13.283 1.00 18.56 ? 476 TYR A CB 1 ATOM 3782 C CG . TYR A 1 459 ? 14.356 14.877 -11.885 1.00 19.58 ? 476 TYR A CG 1 ATOM 3783 C CD1 . TYR A 1 459 ? 13.044 15.245 -11.612 1.00 20.29 ? 476 TYR A CD1 1 ATOM 3784 C CD2 . TYR A 1 459 ? 15.146 14.453 -10.825 1.00 20.44 ? 476 TYR A CD2 1 ATOM 3785 C CE1 . TYR A 1 459 ? 12.529 15.166 -10.332 1.00 21.05 ? 476 TYR A CE1 1 ATOM 3786 C CE2 . TYR A 1 459 ? 14.637 14.375 -9.535 1.00 21.00 ? 476 TYR A CE2 1 ATOM 3787 C CZ . TYR A 1 459 ? 13.327 14.747 -9.299 1.00 20.95 ? 476 TYR A CZ 1 ATOM 3788 O OH . TYR A 1 459 ? 12.787 14.676 -8.038 1.00 22.44 ? 476 TYR A OH 1 ATOM 3789 N N . SER A 1 460 ? 15.965 16.386 -15.966 1.00 17.27 ? 477 SER A N 1 ATOM 3790 C CA . SER A 1 460 ? 16.863 16.249 -17.119 1.00 16.72 ? 477 SER A CA 1 ATOM 3791 C C . SER A 1 460 ? 17.171 17.558 -17.864 1.00 16.84 ? 477 SER A C 1 ATOM 3792 O O . SER A 1 460 ? 18.130 17.606 -18.641 1.00 17.06 ? 477 SER A O 1 ATOM 3793 C CB . SER A 1 460 ? 16.308 15.215 -18.097 1.00 16.72 ? 477 SER A CB 1 ATOM 3794 O OG . SER A 1 460 ? 16.371 13.915 -17.523 1.00 16.62 ? 477 SER A OG 1 ATOM 3795 N N . GLY A 1 461 ? 16.368 18.595 -17.652 1.00 16.20 ? 478 GLY A N 1 ATOM 3796 C CA . GLY A 1 461 ? 16.533 19.855 -18.387 1.00 16.45 ? 478 GLY A CA 1 ATOM 3797 C C . GLY A 1 461 ? 16.378 19.681 -19.883 1.00 16.08 ? 478 GLY A C 1 ATOM 3798 O O . GLY A 1 461 ? 17.144 20.250 -20.665 1.00 17.02 ? 478 GLY A O 1 ATOM 3799 N N . ILE A 1 462 ? 15.406 18.862 -20.271 1.00 16.06 ? 479 ILE A N 1 ATOM 3800 C CA . ILE A 1 462 ? 15.039 18.679 -21.656 1.00 15.67 ? 479 ILE A CA 1 ATOM 3801 C C . ILE A 1 462 ? 13.555 18.969 -21.798 1.00 15.85 ? 479 ILE A C 1 ATOM 3802 O O . ILE A 1 462 ? 12.810 18.990 -20.800 1.00 16.26 ? 479 ILE A O 1 ATOM 3803 C CB . ILE A 1 462 ? 15.412 17.275 -22.208 1.00 15.25 ? 479 ILE A CB 1 ATOM 3804 C CG1 . ILE A 1 462 ? 14.627 16.135 -21.525 1.00 15.54 ? 479 ILE A CG1 1 ATOM 3805 C CG2 . ILE A 1 462 ? 16.906 17.036 -22.073 1.00 15.15 ? 479 ILE A CG2 1 ATOM 3806 C CD1 . ILE A 1 462 ? 13.226 15.913 -22.058 1.00 15.78 ? 479 ILE A CD1 1 ATOM 3807 N N . GLU A 1 463 ? 13.134 19.179 -23.043 1.00 16.05 ? 480 GLU A N 1 ATOM 3808 C CA . GLU A 1 463 ? 11.738 19.473 -23.348 1.00 16.16 ? 480 GLU A CA 1 ATOM 3809 C C . GLU A 1 463 ? 11.356 19.027 -24.738 1.00 16.40 ? 480 GLU A C 1 ATOM 3810 O O . GLU A 1 463 ? 12.224 18.854 -25.592 1.00 15.79 ? 480 GLU A O 1 ATOM 3811 C CB . GLU A 1 463 ? 11.461 20.972 -23.209 1.00 16.53 ? 480 GLU A CB 1 ATOM 3812 C CG . GLU A 1 463 ? 12.282 21.835 -24.154 1.00 16.80 ? 480 GLU A CG 1 ATOM 3813 C CD . GLU A 1 463 ? 11.964 23.319 -24.061 1.00 17.11 ? 480 GLU A CD 1 ATOM 3814 O OE1 . GLU A 1 463 ? 11.545 23.790 -22.999 1.00 17.46 ? 480 GLU A OE1 1 ATOM 3815 O OE2 . GLU A 1 463 ? 12.144 24.016 -25.072 1.00 17.87 ? 480 GLU A OE2 1 ATOM 3816 N N . PRO A 1 464 ? 10.042 18.886 -24.988 1.00 15.97 ? 481 PRO A N 1 ATOM 3817 C CA . PRO A 1 464 ? 9.588 18.572 -26.332 1.00 16.11 ? 481 PRO A CA 1 ATOM 3818 C C . PRO A 1 464 ? 10.009 19.617 -27.363 1.00 16.02 ? 481 PRO A C 1 ATOM 3819 O O . PRO A 1 464 ? 10.261 20.765 -26.997 1.00 16.00 ? 481 PRO A O 1 ATOM 3820 C CB . PRO A 1 464 ? 8.077 18.548 -26.178 1.00 15.92 ? 481 PRO A CB 1 ATOM 3821 C CG . PRO A 1 464 ? 7.871 18.119 -24.766 1.00 16.01 ? 481 PRO A CG 1 ATOM 3822 C CD . PRO A 1 464 ? 8.917 18.891 -24.036 1.00 16.03 ? 481 PRO A CD 1 ATOM 3823 N N . PRO A 1 465 ? 10.094 19.222 -28.641 1.00 16.61 ? 482 PRO A N 1 ATOM 3824 C CA . PRO A 1 465 ? 10.451 20.166 -29.696 1.00 16.76 ? 482 PRO A CA 1 ATOM 3825 C C . PRO A 1 465 ? 9.353 21.170 -29.996 1.00 17.50 ? 482 PRO A C 1 ATOM 3826 O O . PRO A 1 465 ? 9.634 22.205 -30.577 1.00 17.56 ? 482 PRO A O 1 ATOM 3827 C CB . PRO A 1 465 ? 10.649 19.277 -30.915 1.00 16.64 ? 482 PRO A CB 1 ATOM 3828 C CG . PRO A 1 465 ? 9.799 18.085 -30.674 1.00 16.55 ? 482 PRO A CG 1 ATOM 3829 C CD . PRO A 1 465 ? 9.777 17.889 -29.185 1.00 16.68 ? 482 PRO A CD 1 ATOM 3830 N N . VAL A 1 466 ? 8.120 20.827 -29.646 1.00 17.84 ? 483 VAL A N 1 ATOM 3831 C CA . VAL A 1 466 ? 6.947 21.631 -29.956 1.00 18.67 ? 483 VAL A CA 1 ATOM 3832 C C . VAL A 1 466 ? 6.093 21.659 -28.715 1.00 19.00 ? 483 VAL A C 1 ATOM 3833 O O . VAL A 1 466 ? 6.274 20.815 -27.823 1.00 17.59 ? 483 VAL A O 1 ATOM 3834 C CB . VAL A 1 466 ? 6.143 21.038 -31.132 1.00 18.83 ? 483 VAL A CB 1 ATOM 3835 C CG1 . VAL A 1 466 ? 6.983 21.057 -32.398 1.00 19.36 ? 483 VAL A CG1 1 ATOM 3836 C CG2 . VAL A 1 466 ? 5.655 19.622 -30.839 1.00 19.75 ? 483 VAL A CG2 1 ATOM 3837 N N . VAL A 1 467 ? 5.160 22.613 -28.661 1.00 18.87 ? 484 VAL A N 1 ATOM 3838 C CA . VAL A 1 467 ? 4.295 22.761 -27.500 1.00 18.98 ? 484 VAL A CA 1 ATOM 3839 C C . VAL A 1 467 ? 3.333 21.576 -27.465 1.00 18.95 ? 484 VAL A C 1 ATOM 3840 O O . VAL A 1 467 ? 2.724 21.222 -28.478 1.00 19.73 ? 484 VAL A O 1 ATOM 3841 C CB . VAL A 1 467 ? 3.523 24.108 -27.499 1.00 19.64 ? 484 VAL A CB 1 ATOM 3842 C CG1 . VAL A 1 467 ? 2.567 24.190 -26.314 1.00 20.38 ? 484 VAL A CG1 1 ATOM 3843 C CG2 . VAL A 1 467 ? 4.500 25.279 -27.445 1.00 19.73 ? 484 VAL A CG2 1 ATOM 3844 N N . ARG A 1 468 ? 3.243 20.950 -26.298 1.00 18.55 ? 485 ARG A N 1 ATOM 3845 C CA . ARG A 1 468 ? 2.281 19.910 -26.021 1.00 18.13 ? 485 ARG A CA 1 ATOM 3846 C C . ARG A 1 468 ? 1.253 20.460 -25.048 1.00 18.34 ? 485 ARG A C 1 ATOM 3847 O O . ARG A 1 468 ? 1.388 21.566 -24.539 1.00 18.81 ? 485 ARG A O 1 ATOM 3848 C CB . ARG A 1 468 ? 2.979 18.681 -25.412 1.00 18.24 ? 485 ARG A CB 1 ATOM 3849 C CG . ARG A 1 468 ? 4.144 18.143 -26.240 1.00 17.90 ? 485 ARG A CG 1 ATOM 3850 C CD . ARG A 1 468 ? 3.699 17.639 -27.605 1.00 18.27 ? 485 ARG A CD 1 ATOM 3851 N NE . ARG A 1 468 ? 3.245 16.244 -27.596 1.00 18.08 ? 485 ARG A NE 1 ATOM 3852 C CZ . ARG A 1 468 ? 2.763 15.601 -28.661 1.00 18.59 ? 485 ARG A CZ 1 ATOM 3853 N NH1 . ARG A 1 468 ? 2.613 16.222 -29.833 1.00 18.41 ? 485 ARG A NH1 1 ATOM 3854 N NH2 . ARG A 1 468 ? 2.410 14.325 -28.562 1.00 18.81 ? 485 ARG A NH2 1 ATOM 3855 N N . SER A 1 469 ? 0.216 19.679 -24.821 1.00 18.56 ? 486 SER A N 1 ATOM 3856 C CA . SER A 1 469 ? -0.839 20.049 -23.900 1.00 19.31 ? 486 SER A CA 1 ATOM 3857 C C . SER A 1 469 ? -1.469 18.783 -23.334 1.00 19.56 ? 486 SER A C 1 ATOM 3858 O O . SER A 1 469 ? -1.028 17.658 -23.628 1.00 18.53 ? 486 SER A O 1 ATOM 3859 C CB . SER A 1 469 ? -1.872 20.929 -24.625 1.00 19.23 ? 486 SER A CB 1 ATOM 3860 O OG . SER A 1 469 ? -2.741 20.157 -25.445 1.00 20.05 ? 486 SER A OG 1 ATOM 3861 N N . GLU A 1 470 ? -2.514 18.960 -22.534 1.00 19.41 ? 487 GLU A N 1 ATOM 3862 C CA . GLU A 1 470 ? -3.260 17.823 -21.997 1.00 20.43 ? 487 GLU A CA 1 ATOM 3863 C C . GLU A 1 470 ? -4.100 17.078 -23.041 1.00 20.94 ? 487 GLU A C 1 ATOM 3864 O O . GLU A 1 470 ? -4.637 16.006 -22.744 1.00 20.89 ? 487 GLU A O 1 ATOM 3865 C CB . GLU A 1 470 ? -4.119 18.261 -20.809 1.00 20.50 ? 487 GLU A CB 1 ATOM 3866 C CG . GLU A 1 470 ? -3.298 18.806 -19.652 1.00 20.70 ? 487 GLU A CG 1 ATOM 3867 C CD . GLU A 1 470 ? -2.394 17.767 -18.994 1.00 20.66 ? 487 GLU A CD 1 ATOM 3868 O OE1 . GLU A 1 470 ? -2.582 16.542 -19.192 1.00 20.94 ? 487 GLU A OE1 1 ATOM 3869 O OE2 . GLU A 1 470 ? -1.480 18.175 -18.255 1.00 20.00 ? 487 GLU A OE2 1 ATOM 3870 N N . LYS A 1 471 ? -4.176 17.603 -24.265 1.00 21.39 ? 488 LYS A N 1 ATOM 3871 C CA . LYS A 1 471 ? -4.724 16.837 -25.382 1.00 21.95 ? 488 LYS A CA 1 ATOM 3872 C C . LYS A 1 471 ? -3.738 15.796 -25.944 1.00 21.27 ? 488 LYS A C 1 ATOM 3873 O O . LYS A 1 471 ? -4.131 14.953 -26.741 1.00 21.65 ? 488 LYS A O 1 ATOM 3874 C CB . LYS A 1 471 ? -5.222 17.772 -26.476 1.00 23.65 ? 488 LYS A CB 1 ATOM 3875 C CG . LYS A 1 471 ? -6.386 18.637 -25.976 1.00 25.70 ? 488 LYS A CG 1 ATOM 3876 C CD . LYS A 1 471 ? -7.319 19.069 -27.086 1.00 27.08 ? 488 LYS A CD 1 ATOM 3877 C CE . LYS A 1 471 ? -8.593 19.679 -26.515 1.00 28.51 ? 488 LYS A CE 1 ATOM 3878 N NZ . LYS A 1 471 ? -8.309 20.875 -25.683 1.00 28.82 ? 488 LYS A NZ 1 ATOM 3879 N N . ASP A 1 472 ? -2.475 15.863 -25.531 1.00 19.05 ? 489 ASP A N 1 ATOM 3880 C CA . ASP A 1 472 ? -1.499 14.816 -25.826 1.00 18.28 ? 489 ASP A CA 1 ATOM 3881 C C . ASP A 1 472 ? -1.308 13.968 -24.580 1.00 18.23 ? 489 ASP A C 1 ATOM 3882 O O . ASP A 1 472 ? -1.650 14.381 -23.472 1.00 17.27 ? 489 ASP A O 1 ATOM 3883 C CB . ASP A 1 472 ? -0.167 15.438 -26.237 1.00 18.07 ? 489 ASP A CB 1 ATOM 3884 C CG . ASP A 1 472 ? -0.334 16.548 -27.244 1.00 18.07 ? 489 ASP A CG 1 ATOM 3885 O OD1 . ASP A 1 472 ? -0.872 16.264 -28.329 1.00 19.15 ? 489 ASP A OD1 1 ATOM 3886 O OD2 . ASP A 1 472 ? 0.058 17.701 -26.947 1.00 17.89 ? 489 ASP A OD2 1 ATOM 3887 N N . PHE A 1 473 ? -0.761 12.774 -24.769 1.00 17.87 ? 490 PHE A N 1 ATOM 3888 C CA . PHE A 1 473 ? -0.408 11.935 -23.648 1.00 17.63 ? 490 PHE A CA 1 ATOM 3889 C C . PHE A 1 473 ? 0.864 11.186 -23.998 1.00 16.67 ? 490 PHE A C 1 ATOM 3890 O O . PHE A 1 473 ? 0.841 10.164 -24.664 1.00 16.38 ? 490 PHE A O 1 ATOM 3891 C CB . PHE A 1 473 ? -1.555 11.007 -23.260 1.00 18.31 ? 490 PHE A CB 1 ATOM 3892 C CG . PHE A 1 473 ? -1.312 10.299 -21.975 1.00 18.41 ? 490 PHE A CG 1 ATOM 3893 C CD1 . PHE A 1 473 ? -1.194 11.021 -20.798 1.00 18.95 ? 490 PHE A CD1 1 ATOM 3894 C CD2 . PHE A 1 473 ? -1.152 8.919 -21.938 1.00 18.55 ? 490 PHE A CD2 1 ATOM 3895 C CE1 . PHE A 1 473 ? -0.936 10.378 -19.599 1.00 19.27 ? 490 PHE A CE1 1 ATOM 3896 C CE2 . PHE A 1 473 ? -0.910 8.270 -20.740 1.00 18.50 ? 490 PHE A CE2 1 ATOM 3897 C CZ . PHE A 1 473 ? -0.790 9.002 -19.575 1.00 19.16 ? 490 PHE A CZ 1 ATOM 3898 N N . ASP A 1 474 ? 1.982 11.727 -23.539 1.00 15.61 ? 491 ASP A N 1 ATOM 3899 C CA . ASP A 1 474 ? 3.280 11.382 -24.100 1.00 15.14 ? 491 ASP A CA 1 ATOM 3900 C C . ASP A 1 474 ? 4.035 10.251 -23.400 1.00 15.26 ? 491 ASP A C 1 ATOM 3901 O O . ASP A 1 474 ? 4.894 9.630 -24.032 1.00 14.90 ? 491 ASP A O 1 ATOM 3902 C CB . ASP A 1 474 ? 4.121 12.653 -24.187 1.00 15.56 ? 491 ASP A CB 1 ATOM 3903 C CG . ASP A 1 474 ? 3.569 13.628 -25.208 1.00 15.61 ? 491 ASP A CG 1 ATOM 3904 O OD1 . ASP A 1 474 ? 3.199 13.154 -26.301 1.00 16.26 ? 491 ASP A OD1 1 ATOM 3905 O OD2 . ASP A 1 474 ? 3.503 14.851 -24.941 1.00 15.32 ? 491 ASP A OD2 1 ATOM 3906 N N . ALA A 1 475 ? 3.730 9.973 -22.129 1.00 14.62 ? 492 ALA A N 1 ATOM 3907 C CA . ALA A 1 475 ? 4.488 8.964 -21.380 1.00 14.96 ? 492 ALA A CA 1 ATOM 3908 C C . ALA A 1 475 ? 4.518 7.582 -22.064 1.00 15.11 ? 492 ALA A C 1 ATOM 3909 O O . ALA A 1 475 ? 5.598 7.005 -22.185 1.00 15.34 ? 492 ALA A O 1 ATOM 3910 C CB . ALA A 1 475 ? 4.011 8.853 -19.938 1.00 15.21 ? 492 ALA A CB 1 ATOM 3911 N N . PRO A 1 476 ? 3.367 7.073 -22.557 1.00 15.00 ? 493 PRO A N 1 ATOM 3912 C CA . PRO A 1 476 ? 3.402 5.727 -23.177 1.00 15.36 ? 493 PRO A CA 1 ATOM 3913 C C . PRO A 1 476 ? 4.230 5.575 -24.459 1.00 15.56 ? 493 PRO A C 1 ATOM 3914 O O . PRO A 1 476 ? 4.386 4.455 -24.938 1.00 15.68 ? 493 PRO A O 1 ATOM 3915 C CB . PRO A 1 476 ? 1.922 5.429 -23.476 1.00 15.16 ? 493 PRO A CB 1 ATOM 3916 C CG . PRO A 1 476 ? 1.164 6.306 -22.541 1.00 15.20 ? 493 PRO A CG 1 ATOM 3917 C CD . PRO A 1 476 ? 1.978 7.554 -22.416 1.00 15.13 ? 493 PRO A CD 1 ATOM 3918 N N . ALA A 1 477 ? 4.736 6.674 -25.017 1.00 15.48 ? 494 ALA A N 1 ATOM 3919 C CA . ALA A 1 477 ? 5.645 6.602 -26.160 1.00 15.71 ? 494 ALA A CA 1 ATOM 3920 C C . ALA A 1 477 ? 6.998 5.982 -25.817 1.00 15.33 ? 494 ALA A C 1 ATOM 3921 O O . ALA A 1 477 ? 7.761 5.697 -26.721 1.00 16.12 ? 494 ALA A O 1 ATOM 3922 C CB . ALA A 1 477 ? 5.842 7.975 -26.775 1.00 15.89 ? 494 ALA A CB 1 ATOM 3923 N N . LYS A 1 478 ? 7.303 5.830 -24.525 1.00 15.45 ? 495 LYS A N 1 ATOM 3924 C CA . LYS A 1 478 ? 8.420 5.016 -24.050 1.00 15.28 ? 495 LYS A CA 1 ATOM 3925 C C . LYS A 1 478 ? 7.939 3.583 -23.871 1.00 15.29 ? 495 LYS A C 1 ATOM 3926 O O . LYS A 1 478 ? 6.924 3.346 -23.205 1.00 14.53 ? 495 LYS A O 1 ATOM 3927 C CB . LYS A 1 478 ? 8.962 5.573 -22.727 1.00 15.30 ? 495 LYS A CB 1 ATOM 3928 C CG . LYS A 1 478 ? 10.128 4.812 -22.105 1.00 15.42 ? 495 LYS A CG 1 ATOM 3929 C CD . LYS A 1 478 ? 11.332 4.734 -23.032 1.00 15.55 ? 495 LYS A CD 1 ATOM 3930 C CE . LYS A 1 478 ? 12.460 3.914 -22.440 1.00 15.75 ? 495 LYS A CE 1 ATOM 3931 N NZ . LYS A 1 478 ? 13.421 3.471 -23.485 1.00 16.39 ? 495 LYS A NZ 1 ATOM 3932 N N . TYR A 1 479 ? 8.667 2.635 -24.470 1.00 15.84 ? 496 TYR A N 1 ATOM 3933 C CA . TYR A 1 479 ? 8.265 1.229 -24.496 1.00 16.31 ? 496 TYR A CA 1 ATOM 3934 C C . TYR A 1 479 ? 7.810 0.726 -23.136 1.00 15.91 ? 496 TYR A C 1 ATOM 3935 O O . TYR A 1 479 ? 6.719 0.188 -23.000 1.00 16.46 ? 496 TYR A O 1 ATOM 3936 C CB . TYR A 1 479 ? 9.422 0.336 -24.968 1.00 17.20 ? 496 TYR A CB 1 ATOM 3937 C CG . TYR A 1 479 ? 9.102 -1.129 -24.811 1.00 18.21 ? 496 TYR A CG 1 ATOM 3938 C CD1 . TYR A 1 479 ? 8.222 -1.761 -25.686 1.00 19.29 ? 496 TYR A CD1 1 ATOM 3939 C CD2 . TYR A 1 479 ? 9.628 -1.875 -23.753 1.00 19.07 ? 496 TYR A CD2 1 ATOM 3940 C CE1 . TYR A 1 479 ? 7.892 -3.096 -25.531 1.00 20.05 ? 496 TYR A CE1 1 ATOM 3941 C CE2 . TYR A 1 479 ? 9.291 -3.213 -23.588 1.00 20.10 ? 496 TYR A CE2 1 ATOM 3942 C CZ . TYR A 1 479 ? 8.427 -3.814 -24.484 1.00 20.71 ? 496 TYR A CZ 1 ATOM 3943 O OH . TYR A 1 479 ? 8.095 -5.141 -24.331 1.00 21.80 ? 496 TYR A OH 1 ATOM 3944 N N . HIS A 1 480 ? 8.650 0.945 -22.130 1.00 15.19 ? 497 HIS A N 1 ATOM 3945 C CA . HIS A 1 480 ? 8.460 0.347 -20.801 1.00 15.30 ? 497 HIS A CA 1 ATOM 3946 C C . HIS A 1 480 ? 7.198 0.872 -20.117 1.00 15.27 ? 497 HIS A C 1 ATOM 3947 O O . HIS A 1 480 ? 6.622 0.202 -19.252 1.00 14.75 ? 497 HIS A O 1 ATOM 3948 C CB . HIS A 1 480 ? 9.670 0.624 -19.911 1.00 15.43 ? 497 HIS A CB 1 ATOM 3949 C CG . HIS A 1 480 ? 10.937 0.030 -20.431 1.00 15.44 ? 497 HIS A CG 1 ATOM 3950 N ND1 . HIS A 1 480 ? 11.582 0.513 -21.547 1.00 15.46 ? 497 HIS A ND1 1 ATOM 3951 C CD2 . HIS A 1 480 ? 11.661 -1.031 -20.009 1.00 15.77 ? 497 HIS A CD2 1 ATOM 3952 C CE1 . HIS A 1 480 ? 12.650 -0.222 -21.790 1.00 15.52 ? 497 HIS A CE1 1 ATOM 3953 N NE2 . HIS A 1 480 ? 12.718 -1.168 -20.875 1.00 15.37 ? 497 HIS A NE2 1 ATOM 3954 N N . ILE A 1 481 ? 6.781 2.083 -20.493 1.00 14.85 ? 498 ILE A N 1 ATOM 3955 C CA . ILE A 1 481 ? 5.553 2.655 -19.965 1.00 15.26 ? 498 ILE A CA 1 ATOM 3956 C C . ILE A 1 481 ? 4.336 1.966 -20.606 1.00 15.36 ? 498 ILE A C 1 ATOM 3957 O O . ILE A 1 481 ? 3.407 1.561 -19.895 1.00 16.78 ? 498 ILE A O 1 ATOM 3958 C CB . ILE A 1 481 ? 5.554 4.203 -20.093 1.00 15.84 ? 498 ILE A CB 1 ATOM 3959 C CG1 . ILE A 1 481 ? 6.762 4.756 -19.296 1.00 16.69 ? 498 ILE A CG1 1 ATOM 3960 C CG2 . ILE A 1 481 ? 4.222 4.776 -19.627 1.00 15.74 ? 498 ILE A CG2 1 ATOM 3961 C CD1 . ILE A 1 481 ? 6.761 6.235 -18.977 1.00 17.54 ? 498 ILE A CD1 1 ATOM 3962 N N . SER A 1 482 ? 4.342 1.808 -21.927 1.00 15.29 ? 499 SER A N 1 ATOM 3963 C CA . SER A 1 482 ? 3.298 1.017 -22.614 1.00 15.77 ? 499 SER A CA 1 ATOM 3964 C C . SER A 1 482 ? 3.292 -0.456 -22.186 1.00 16.19 ? 499 SER A C 1 ATOM 3965 O O . SER A 1 482 ? 2.237 -1.078 -22.125 1.00 17.09 ? 499 SER A O 1 ATOM 3966 C CB . SER A 1 482 ? 3.436 1.098 -24.141 1.00 15.92 ? 499 SER A CB 1 ATOM 3967 O OG . SER A 1 482 ? 2.878 2.298 -24.649 1.00 15.78 ? 499 SER A OG 1 ATOM 3968 N N . ALA A 1 483 ? 4.465 -1.003 -21.888 1.00 16.68 ? 500 ALA A N 1 ATOM 3969 C CA . ALA A 1 483 ? 4.606 -2.426 -21.571 1.00 16.59 ? 500 ALA A CA 1 ATOM 3970 C C . ALA A 1 483 ? 4.492 -2.763 -20.077 1.00 16.84 ? 500 ALA A C 1 ATOM 3971 O O . ALA A 1 483 ? 4.590 -3.940 -19.719 1.00 16.65 ? 500 ALA A O 1 ATOM 3972 C CB . ALA A 1 483 ? 5.928 -2.937 -22.135 1.00 16.81 ? 500 ALA A CB 1 ATOM 3973 N N . ASP A 1 484 ? 4.274 -1.762 -19.215 1.00 16.63 ? 501 ASP A N 1 ATOM 3974 C CA . ASP A 1 484 ? 4.214 -1.961 -17.758 1.00 16.76 ? 501 ASP A CA 1 ATOM 3975 C C . ASP A 1 484 ? 5.471 -2.689 -17.230 1.00 16.29 ? 501 ASP A C 1 ATOM 3976 O O . ASP A 1 484 ? 5.376 -3.712 -16.524 1.00 16.07 ? 501 ASP A O 1 ATOM 3977 C CB . ASP A 1 484 ? 2.927 -2.719 -17.395 1.00 17.02 ? 501 ASP A CB 1 ATOM 3978 C CG . ASP A 1 484 ? 2.784 -2.992 -15.908 1.00 17.44 ? 501 ASP A CG 1 ATOM 3979 O OD1 . ASP A 1 484 ? 3.175 -2.140 -15.099 1.00 17.48 ? 501 ASP A OD1 1 ATOM 3980 O OD2 . ASP A 1 484 ? 2.213 -4.052 -15.565 1.00 18.31 ? 501 ASP A OD2 1 ATOM 3981 N N . VAL A 1 485 ? 6.638 -2.180 -17.606 1.00 15.34 ? 502 VAL A N 1 ATOM 3982 C CA . VAL A 1 485 ? 7.910 -2.669 -17.072 1.00 15.71 ? 502 VAL A CA 1 ATOM 3983 C C . VAL A 1 485 ? 8.453 -1.584 -16.163 1.00 15.99 ? 502 VAL A C 1 ATOM 3984 O O . VAL A 1 485 ? 8.661 -0.434 -16.597 1.00 15.48 ? 502 VAL A O 1 ATOM 3985 C CB . VAL A 1 485 ? 8.947 -2.971 -18.173 1.00 15.78 ? 502 VAL A CB 1 ATOM 3986 C CG1 . VAL A 1 485 ? 10.246 -3.508 -17.566 1.00 15.94 ? 502 VAL A CG1 1 ATOM 3987 C CG2 . VAL A 1 485 ? 8.380 -3.958 -19.183 1.00 16.50 ? 502 VAL A CG2 1 ATOM 3988 N N . GLU A 1 486 ? 8.648 -1.951 -14.900 1.00 16.01 ? 503 GLU A N 1 ATOM 3989 C CA . GLU A 1 486 ? 9.275 -1.081 -13.903 1.00 16.42 ? 503 GLU A CA 1 ATOM 3990 C C . GLU A 1 486 ? 10.639 -0.580 -14.432 1.00 15.90 ? 503 GLU A C 1 ATOM 3991 O O . GLU A 1 486 ? 11.364 -1.338 -15.076 1.00 15.98 ? 503 GLU A O 1 ATOM 3992 C CB . GLU A 1 486 ? 9.434 -1.870 -12.592 1.00 16.63 ? 503 GLU A CB 1 ATOM 3993 C CG . GLU A 1 486 ? 9.927 -1.065 -11.401 1.00 17.16 ? 503 GLU A CG 1 ATOM 3994 C CD . GLU A 1 486 ? 11.413 -1.220 -11.120 1.00 17.66 ? 503 GLU A CD 1 ATOM 3995 O OE1 . GLU A 1 486 ? 12.191 -1.560 -12.029 1.00 17.30 ? 503 GLU A OE1 1 ATOM 3996 O OE2 . GLU A 1 486 ? 11.810 -1.000 -9.959 1.00 18.71 ? 503 GLU A OE2 1 ATOM 3997 N N . TYR A 1 487 ? 10.953 0.696 -14.191 1.00 15.57 ? 504 TYR A N 1 ATOM 3998 C CA . TYR A 1 487 ? 12.153 1.331 -14.742 1.00 15.60 ? 504 TYR A CA 1 ATOM 3999 C C . TYR A 1 487 ? 13.249 1.665 -13.724 1.00 15.49 ? 504 TYR A C 1 ATOM 4000 O O . TYR A 1 487 ? 14.401 1.891 -14.112 1.00 15.05 ? 504 TYR A O 1 ATOM 4001 C CB . TYR A 1 487 ? 11.786 2.597 -15.539 1.00 15.99 ? 504 TYR A CB 1 ATOM 4002 C CG . TYR A 1 487 ? 12.702 2.807 -16.715 1.00 16.23 ? 504 TYR A CG 1 ATOM 4003 C CD1 . TYR A 1 487 ? 12.495 2.107 -17.902 1.00 16.36 ? 504 TYR A CD1 1 ATOM 4004 C CD2 . TYR A 1 487 ? 13.798 3.662 -16.635 1.00 16.46 ? 504 TYR A CD2 1 ATOM 4005 C CE1 . TYR A 1 487 ? 13.345 2.261 -18.981 1.00 16.05 ? 504 TYR A CE1 1 ATOM 4006 C CE2 . TYR A 1 487 ? 14.661 3.825 -17.710 1.00 16.40 ? 504 TYR A CE2 1 ATOM 4007 C CZ . TYR A 1 487 ? 14.426 3.126 -18.883 1.00 16.18 ? 504 TYR A CZ 1 ATOM 4008 O OH . TYR A 1 487 ? 15.269 3.277 -19.966 1.00 15.48 ? 504 TYR A OH 1 ATOM 4009 N N . LEU A 1 488 ? 12.923 1.673 -12.434 1.00 15.78 ? 505 LEU A N 1 ATOM 4010 C CA . LEU A 1 488 ? 13.934 1.972 -11.415 1.00 16.45 ? 505 LEU A CA 1 ATOM 4011 C C . LEU A 1 488 ? 15.095 0.977 -11.462 1.00 16.51 ? 505 LEU A C 1 ATOM 4012 O O . LEU A 1 488 ? 16.227 1.341 -11.135 1.00 16.52 ? 505 LEU A O 1 ATOM 4013 C CB . LEU A 1 488 ? 13.335 1.995 -10.012 1.00 16.54 ? 505 LEU A CB 1 ATOM 4014 C CG . LEU A 1 488 ? 14.081 2.819 -8.959 1.00 16.47 ? 505 LEU A CG 1 ATOM 4015 C CD1 . LEU A 1 488 ? 13.833 4.306 -9.148 1.00 16.39 ? 505 LEU A CD1 1 ATOM 4016 C CD2 . LEU A 1 488 ? 13.654 2.372 -7.569 1.00 16.49 ? 505 LEU A CD2 1 ATOM 4017 N N . ARG A 1 489 ? 14.803 -0.261 -11.861 1.00 16.75 ? 506 ARG A N 1 ATOM 4018 C CA . ARG A 1 489 ? 15.828 -1.285 -12.116 1.00 16.88 ? 506 ARG A CA 1 ATOM 4019 C C . ARG A 1 489 ? 17.009 -0.761 -12.940 1.00 16.81 ? 506 ARG A C 1 ATOM 4020 O O . ARG A 1 489 ? 18.151 -1.151 -12.695 1.00 16.68 ? 506 ARG A O 1 ATOM 4021 C CB . ARG A 1 489 ? 15.211 -2.492 -12.835 1.00 17.33 ? 506 ARG A CB 1 ATOM 4022 C CG . ARG A 1 489 ? 14.658 -2.187 -14.219 1.00 17.75 ? 506 ARG A CG 1 ATOM 4023 C CD . ARG A 1 489 ? 13.888 -3.348 -14.817 1.00 18.48 ? 506 ARG A CD 1 ATOM 4024 N NE . ARG A 1 489 ? 12.785 -3.800 -13.977 1.00 18.88 ? 506 ARG A NE 1 ATOM 4025 C CZ . ARG A 1 489 ? 12.015 -4.850 -14.261 1.00 20.64 ? 506 ARG A CZ 1 ATOM 4026 N NH1 . ARG A 1 489 ? 12.200 -5.560 -15.377 1.00 20.69 ? 506 ARG A NH1 1 ATOM 4027 N NH2 . ARG A 1 489 ? 11.039 -5.186 -13.432 1.00 21.84 ? 506 ARG A NH2 1 ATOM 4028 N N . TYR A 1 490 ? 16.736 0.105 -13.921 1.00 16.74 ? 507 TYR A N 1 ATOM 4029 C CA . TYR A 1 490 ? 17.797 0.663 -14.781 1.00 16.80 ? 507 TYR A CA 1 ATOM 4030 C C . TYR A 1 490 ? 18.598 1.753 -14.066 1.00 16.55 ? 507 TYR A C 1 ATOM 4031 O O . TYR A 1 490 ? 19.813 1.858 -14.256 1.00 16.18 ? 507 TYR A O 1 ATOM 4032 C CB . TYR A 1 490 ? 17.231 1.181 -16.105 1.00 17.05 ? 507 TYR A CB 1 ATOM 4033 C CG . TYR A 1 490 ? 16.516 0.133 -16.906 1.00 17.68 ? 507 TYR A CG 1 ATOM 4034 C CD1 . TYR A 1 490 ? 17.228 -0.841 -17.609 1.00 18.43 ? 507 TYR A CD1 1 ATOM 4035 C CD2 . TYR A 1 490 ? 15.122 0.091 -16.958 1.00 17.85 ? 507 TYR A CD2 1 ATOM 4036 C CE1 . TYR A 1 490 ? 16.565 -1.818 -18.341 1.00 19.21 ? 507 TYR A CE1 1 ATOM 4037 C CE2 . TYR A 1 490 ? 14.460 -0.887 -17.695 1.00 18.56 ? 507 TYR A CE2 1 ATOM 4038 C CZ . TYR A 1 490 ? 15.185 -1.841 -18.379 1.00 18.86 ? 507 TYR A CZ 1 ATOM 4039 O OH . TYR A 1 490 ? 14.525 -2.819 -19.117 1.00 20.22 ? 507 TYR A OH 1 ATOM 4040 N N . LEU A 1 491 ? 17.940 2.554 -13.233 1.00 16.28 ? 508 LEU A N 1 ATOM 4041 C CA . LEU A 1 491 ? 18.673 3.492 -12.379 1.00 16.82 ? 508 LEU A CA 1 ATOM 4042 C C . LEU A 1 491 ? 19.595 2.727 -11.419 1.00 16.98 ? 508 LEU A C 1 ATOM 4043 O O . LEU A 1 491 ? 20.784 3.031 -11.321 1.00 16.60 ? 508 LEU A O 1 ATOM 4044 C CB . LEU A 1 491 ? 17.733 4.406 -11.606 1.00 16.88 ? 508 LEU A CB 1 ATOM 4045 C CG . LEU A 1 491 ? 18.379 5.367 -10.610 1.00 17.04 ? 508 LEU A CG 1 ATOM 4046 C CD1 . LEU A 1 491 ? 19.402 6.278 -11.280 1.00 17.37 ? 508 LEU A CD1 1 ATOM 4047 C CD2 . LEU A 1 491 ? 17.291 6.178 -9.940 1.00 17.33 ? 508 LEU A CD2 1 ATOM 4048 N N . VAL A 1 492 ? 19.039 1.724 -10.742 1.00 16.61 ? 509 VAL A N 1 ATOM 4049 C CA . VAL A 1 492 ? 19.814 0.868 -9.844 1.00 16.66 ? 509 VAL A CA 1 ATOM 4050 C C . VAL A 1 492 ? 20.990 0.245 -10.592 1.00 16.34 ? 509 VAL A C 1 ATOM 4051 O O . VAL A 1 492 ? 22.125 0.326 -10.133 1.00 16.08 ? 509 VAL A O 1 ATOM 4052 C CB . VAL A 1 492 ? 18.939 -0.240 -9.212 1.00 16.32 ? 509 VAL A CB 1 ATOM 4053 C CG1 . VAL A 1 492 ? 19.781 -1.204 -8.385 1.00 16.29 ? 509 VAL A CG1 1 ATOM 4054 C CG2 . VAL A 1 492 ? 17.852 0.365 -8.326 1.00 16.70 ? 509 VAL A CG2 1 ATOM 4055 N N . SER A 1 493 ? 20.702 -0.357 -11.748 1.00 16.35 ? 510 SER A N 1 ATOM 4056 C CA . SER A 1 493 ? 21.717 -0.955 -12.612 1.00 16.72 ? 510 SER A CA 1 ATOM 4057 C C . SER A 1 493 ? 22.872 -0.019 -12.940 1.00 16.69 ? 510 SER A C 1 ATOM 4058 O O . SER A 1 493 ? 24.037 -0.419 -12.853 1.00 15.87 ? 510 SER A O 1 ATOM 4059 C CB . SER A 1 493 ? 21.105 -1.424 -13.931 1.00 17.21 ? 510 SER A CB 1 ATOM 4060 O OG . SER A 1 493 ? 22.130 -1.807 -14.841 1.00 17.26 ? 510 SER A OG 1 ATOM 4061 N N . PHE A 1 494 ? 22.554 1.210 -13.334 1.00 16.61 ? 511 PHE A N 1 ATOM 4062 C CA . PHE A 1 494 ? 23.592 2.141 -13.801 1.00 17.17 ? 511 PHE A CA 1 ATOM 4063 C C . PHE A 1 494 ? 24.504 2.578 -12.651 1.00 17.69 ? 511 PHE A C 1 ATOM 4064 O O . PHE A 1 494 ? 25.658 2.931 -12.887 1.00 18.28 ? 511 PHE A O 1 ATOM 4065 C CB . PHE A 1 494 ? 22.986 3.339 -14.560 1.00 17.20 ? 511 PHE A CB 1 ATOM 4066 C CG . PHE A 1 494 ? 22.745 3.071 -16.030 1.00 17.03 ? 511 PHE A CG 1 ATOM 4067 C CD1 . PHE A 1 494 ? 22.115 1.901 -16.458 1.00 18.16 ? 511 PHE A CD1 1 ATOM 4068 C CD2 . PHE A 1 494 ? 23.145 3.986 -16.988 1.00 17.53 ? 511 PHE A CD2 1 ATOM 4069 C CE1 . PHE A 1 494 ? 21.886 1.660 -17.812 1.00 18.84 ? 511 PHE A CE1 1 ATOM 4070 C CE2 . PHE A 1 494 ? 22.921 3.755 -18.334 1.00 17.84 ? 511 PHE A CE2 1 ATOM 4071 C CZ . PHE A 1 494 ? 22.291 2.593 -18.750 1.00 18.53 ? 511 PHE A CZ 1 ATOM 4072 N N . ILE A 1 495 ? 24.003 2.532 -11.417 1.00 17.95 ? 512 ILE A N 1 ATOM 4073 C CA . ILE A 1 495 ? 24.846 2.755 -10.237 1.00 18.21 ? 512 ILE A CA 1 ATOM 4074 C C . ILE A 1 495 ? 25.670 1.506 -9.920 1.00 18.67 ? 512 ILE A C 1 ATOM 4075 O O . ILE A 1 495 ? 26.914 1.563 -9.852 1.00 18.10 ? 512 ILE A O 1 ATOM 4076 C CB . ILE A 1 495 ? 24.021 3.185 -9.002 1.00 19.12 ? 512 ILE A CB 1 ATOM 4077 C CG1 . ILE A 1 495 ? 23.326 4.522 -9.285 1.00 19.58 ? 512 ILE A CG1 1 ATOM 4078 C CG2 . ILE A 1 495 ? 24.906 3.318 -7.755 1.00 19.08 ? 512 ILE A CG2 1 ATOM 4079 C CD1 . ILE A 1 495 ? 22.157 4.816 -8.372 1.00 20.14 ? 512 ILE A CD1 1 ATOM 4080 N N . ILE A 1 496 ? 25.000 0.377 -9.723 1.00 18.02 ? 513 ILE A N 1 ATOM 4081 C CA . ILE A 1 496 ? 25.712 -0.810 -9.241 1.00 18.53 ? 513 ILE A CA 1 ATOM 4082 C C . ILE A 1 496 ? 26.631 -1.458 -10.273 1.00 17.74 ? 513 ILE A C 1 ATOM 4083 O O . ILE A 1 496 ? 27.601 -2.099 -9.883 1.00 17.97 ? 513 ILE A O 1 ATOM 4084 C CB . ILE A 1 496 ? 24.789 -1.863 -8.601 1.00 19.07 ? 513 ILE A CB 1 ATOM 4085 C CG1 . ILE A 1 496 ? 23.883 -2.528 -9.642 1.00 19.47 ? 513 ILE A CG1 1 ATOM 4086 C CG2 . ILE A 1 496 ? 24.006 -1.238 -7.449 1.00 19.88 ? 513 ILE A CG2 1 ATOM 4087 C CD1 . ILE A 1 496 ? 22.934 -3.544 -9.058 1.00 20.00 ? 513 ILE A CD1 1 ATOM 4088 N N . GLN A 1 497 ? 26.365 -1.274 -11.570 1.00 17.85 ? 514 GLN A N 1 ATOM 4089 C CA . GLN A 1 497 ? 27.260 -1.826 -12.600 1.00 18.07 ? 514 GLN A CA 1 ATOM 4090 C C . GLN A 1 497 ? 28.688 -1.284 -12.483 1.00 18.48 ? 514 GLN A C 1 ATOM 4091 O O . GLN A 1 497 ? 29.633 -1.985 -12.815 1.00 19.00 ? 514 GLN A O 1 ATOM 4092 C CB . GLN A 1 497 ? 26.725 -1.617 -14.019 1.00 17.88 ? 514 GLN A CB 1 ATOM 4093 C CG . GLN A 1 497 ? 26.713 -0.187 -14.531 1.00 17.49 ? 514 GLN A CG 1 ATOM 4094 C CD . GLN A 1 497 ? 26.038 -0.070 -15.886 1.00 17.40 ? 514 GLN A CD 1 ATOM 4095 O OE1 . GLN A 1 497 ? 26.664 0.337 -16.866 1.00 17.50 ? 514 GLN A OE1 1 ATOM 4096 N NE2 . GLN A 1 497 ? 24.752 -0.435 -15.954 1.00 17.51 ? 514 GLN A NE2 1 ATOM 4097 N N . PHE A 1 498 ? 28.837 -0.044 -12.017 1.00 18.58 ? 515 PHE A N 1 ATOM 4098 C CA . PHE A 1 498 ? 30.171 0.489 -11.746 1.00 19.03 ? 515 PHE A CA 1 ATOM 4099 C C . PHE A 1 498 ? 30.821 -0.121 -10.501 1.00 19.22 ? 515 PHE A C 1 ATOM 4100 O O . PHE A 1 498 ? 32.046 -0.238 -10.465 1.00 18.82 ? 515 PHE A O 1 ATOM 4101 C CB . PHE A 1 498 ? 30.173 2.011 -11.711 1.00 18.49 ? 515 PHE A CB 1 ATOM 4102 C CG . PHE A 1 498 ? 29.993 2.626 -13.066 1.00 19.22 ? 515 PHE A CG 1 ATOM 4103 C CD1 . PHE A 1 498 ? 28.727 2.843 -13.566 1.00 19.22 ? 515 PHE A CD1 1 ATOM 4104 C CD2 . PHE A 1 498 ? 31.090 2.929 -13.870 1.00 19.71 ? 515 PHE A CD2 1 ATOM 4105 C CE1 . PHE A 1 498 ? 28.535 3.378 -14.836 1.00 19.36 ? 515 PHE A CE1 1 ATOM 4106 C CE2 . PHE A 1 498 ? 30.912 3.472 -15.141 1.00 19.95 ? 515 PHE A CE2 1 ATOM 4107 C CZ . PHE A 1 498 ? 29.630 3.699 -15.622 1.00 20.03 ? 515 PHE A CZ 1 ATOM 4108 N N . GLN A 1 499 ? 30.015 -0.516 -9.508 1.00 19.66 ? 516 GLN A N 1 ATOM 4109 C CA . GLN A 1 499 ? 30.520 -1.245 -8.345 1.00 20.51 ? 516 GLN A CA 1 ATOM 4110 C C . GLN A 1 499 ? 31.029 -2.603 -8.772 1.00 20.29 ? 516 GLN A C 1 ATOM 4111 O O . GLN A 1 499 ? 32.129 -2.998 -8.377 1.00 21.15 ? 516 GLN A O 1 ATOM 4112 C CB . GLN A 1 499 ? 29.475 -1.416 -7.232 1.00 20.82 ? 516 GLN A CB 1 ATOM 4113 C CG . GLN A 1 499 ? 28.940 -0.120 -6.673 1.00 21.26 ? 516 GLN A CG 1 ATOM 4114 C CD . GLN A 1 499 ? 27.961 -0.318 -5.529 1.00 21.96 ? 516 GLN A CD 1 ATOM 4115 O OE1 . GLN A 1 499 ? 26.797 0.074 -5.632 1.00 22.31 ? 516 GLN A OE1 1 ATOM 4116 N NE2 . GLN A 1 499 ? 28.427 -0.893 -4.425 1.00 22.11 ? 516 GLN A NE2 1 ATOM 4117 N N . PHE A 1 500 ? 30.249 -3.299 -9.599 1.00 19.73 ? 517 PHE A N 1 ATOM 4118 C CA . PHE A 1 500 ? 30.669 -4.596 -10.131 1.00 19.36 ? 517 PHE A CA 1 ATOM 4119 C C . PHE A 1 500 ? 31.903 -4.445 -11.015 1.00 19.86 ? 517 PHE A C 1 ATOM 4120 O O . PHE A 1 500 ? 32.850 -5.226 -10.899 1.00 19.81 ? 517 PHE A O 1 ATOM 4121 C CB . PHE A 1 500 ? 29.562 -5.279 -10.948 1.00 19.58 ? 517 PHE A CB 1 ATOM 4122 C CG . PHE A 1 500 ? 28.314 -5.624 -10.171 1.00 19.81 ? 517 PHE A CG 1 ATOM 4123 C CD1 . PHE A 1 500 ? 28.359 -6.044 -8.841 1.00 20.17 ? 517 PHE A CD1 1 ATOM 4124 C CD2 . PHE A 1 500 ? 27.075 -5.608 -10.815 1.00 20.09 ? 517 PHE A CD2 1 ATOM 4125 C CE1 . PHE A 1 500 ? 27.193 -6.371 -8.161 1.00 20.03 ? 517 PHE A CE1 1 ATOM 4126 C CE2 . PHE A 1 500 ? 25.917 -5.946 -10.137 1.00 19.75 ? 517 PHE A CE2 1 ATOM 4127 C CZ . PHE A 1 500 ? 25.975 -6.325 -8.810 1.00 19.74 ? 517 PHE A CZ 1 ATOM 4128 N N . TYR A 1 501 ? 31.897 -3.432 -11.875 1.00 19.38 ? 518 TYR A N 1 ATOM 4129 C CA . TYR A 1 501 ? 33.002 -3.220 -12.809 1.00 20.18 ? 518 TYR A CA 1 ATOM 4130 C C . TYR A 1 501 ? 34.299 -2.903 -12.087 1.00 20.30 ? 518 TYR A C 1 ATOM 4131 O O . TYR A 1 501 ? 35.319 -3.507 -12.383 1.00 20.72 ? 518 TYR A O 1 ATOM 4132 C CB . TYR A 1 501 ? 32.674 -2.083 -13.766 1.00 20.50 ? 518 TYR A CB 1 ATOM 4133 C CG . TYR A 1 501 ? 33.690 -1.836 -14.866 1.00 20.59 ? 518 TYR A CG 1 ATOM 4134 C CD1 . TYR A 1 501 ? 33.905 -2.773 -15.873 1.00 21.19 ? 518 TYR A CD1 1 ATOM 4135 C CD2 . TYR A 1 501 ? 34.399 -0.643 -14.921 1.00 21.37 ? 518 TYR A CD2 1 ATOM 4136 C CE1 . TYR A 1 501 ? 34.812 -2.533 -16.895 1.00 21.53 ? 518 TYR A CE1 1 ATOM 4137 C CE2 . TYR A 1 501 ? 35.300 -0.390 -15.939 1.00 21.55 ? 518 TYR A CE2 1 ATOM 4138 C CZ . TYR A 1 501 ? 35.498 -1.332 -16.927 1.00 22.01 ? 518 TYR A CZ 1 ATOM 4139 O OH . TYR A 1 501 ? 36.389 -1.065 -17.945 1.00 23.23 ? 518 TYR A OH 1 ATOM 4140 N N . LYS A 1 502 ? 34.258 -1.966 -11.143 1.00 21.22 ? 519 LYS A N 1 ATOM 4141 C CA . LYS A 1 502 ? 35.451 -1.632 -10.346 1.00 21.56 ? 519 LYS A CA 1 ATOM 4142 C C . LYS A 1 502 ? 36.029 -2.869 -9.659 1.00 21.87 ? 519 LYS A C 1 ATOM 4143 O O . LYS A 1 502 ? 37.239 -3.118 -9.734 1.00 21.61 ? 519 LYS A O 1 ATOM 4144 C CB . LYS A 1 502 ? 35.152 -0.531 -9.324 1.00 22.02 ? 519 LYS A CB 1 ATOM 4145 C CG . LYS A 1 502 ? 36.318 -0.194 -8.393 1.00 22.66 ? 519 LYS A CG 1 ATOM 4146 C CD . LYS A 1 502 ? 35.961 0.921 -7.435 1.00 23.76 ? 519 LYS A CD 1 ATOM 4147 C CE . LYS A 1 502 ? 37.058 1.136 -6.406 1.00 25.21 ? 519 LYS A CE 1 ATOM 4148 N NZ . LYS A 1 502 ? 36.642 2.135 -5.399 1.00 24.88 ? 519 LYS A NZ 1 ATOM 4149 N N . SER A 1 503 ? 35.168 -3.645 -9.002 1.00 21.82 ? 520 SER A N 1 ATOM 4150 C CA . SER A 1 503 ? 35.605 -4.849 -8.293 1.00 20.97 ? 520 SER A CA 1 ATOM 4151 C C . SER A 1 503 ? 36.157 -5.921 -9.226 1.00 21.33 ? 520 SER A C 1 ATOM 4152 O O . SER A 1 503 ? 37.211 -6.508 -8.943 1.00 21.92 ? 520 SER A O 1 ATOM 4153 C CB . SER A 1 503 ? 34.476 -5.415 -7.434 1.00 21.05 ? 520 SER A CB 1 ATOM 4154 O OG . SER A 1 503 ? 34.114 -4.480 -6.437 1.00 21.30 ? 520 SER A OG 1 ATOM 4155 N N . ALA A 1 504 ? 35.463 -6.174 -10.334 1.00 21.02 ? 521 ALA A N 1 ATOM 4156 C CA . ALA A 1 504 ? 35.920 -7.151 -11.326 1.00 20.51 ? 521 ALA A CA 1 ATOM 4157 C C . ALA A 1 504 ? 37.256 -6.729 -11.941 1.00 20.66 ? 521 ALA A C 1 ATOM 4158 O O . ALA A 1 504 ? 38.126 -7.569 -12.186 1.00 21.92 ? 521 ALA A O 1 ATOM 4159 C CB . ALA A 1 504 ? 34.873 -7.332 -12.415 1.00 20.74 ? 521 ALA A CB 1 ATOM 4160 N N . CYS A 1 505 ? 37.404 -5.433 -12.188 1.00 21.59 ? 522 CYS A N 1 ATOM 4161 C CA . CYS A 1 505 ? 38.648 -4.873 -12.723 1.00 22.55 ? 522 CYS A CA 1 ATOM 4162 C C . CYS A 1 505 ? 39.823 -5.056 -11.758 1.00 23.10 ? 522 CYS A C 1 ATOM 4163 O O . CYS A 1 505 ? 40.909 -5.432 -12.188 1.00 24.11 ? 522 CYS A O 1 ATOM 4164 C CB . CYS A 1 505 ? 38.467 -3.403 -13.077 1.00 22.31 ? 522 CYS A CB 1 ATOM 4165 S SG . CYS A 1 505 ? 37.396 -3.165 -14.514 1.00 22.28 ? 522 CYS A SG 1 ATOM 4166 N N . ILE A 1 506 ? 39.601 -4.814 -10.467 1.00 23.08 ? 523 ILE A N 1 ATOM 4167 C CA . ILE A 1 506 ? 40.638 -5.057 -9.456 1.00 24.28 ? 523 ILE A CA 1 ATOM 4168 C C . ILE A 1 506 ? 40.990 -6.543 -9.428 1.00 25.29 ? 523 ILE A C 1 ATOM 4169 O O . ILE A 1 506 ? 42.170 -6.899 -9.477 1.00 25.80 ? 523 ILE A O 1 ATOM 4170 C CB . ILE A 1 506 ? 40.240 -4.540 -8.043 1.00 24.16 ? 523 ILE A CB 1 ATOM 4171 C CG1 . ILE A 1 506 ? 40.130 -3.014 -8.045 1.00 24.59 ? 523 ILE A CG1 1 ATOM 4172 C CG2 . ILE A 1 506 ? 41.280 -4.953 -6.993 1.00 25.02 ? 523 ILE A CG2 1 ATOM 4173 C CD1 . ILE A 1 506 ? 39.489 -2.420 -6.811 1.00 24.97 ? 523 ILE A CD1 1 ATOM 4174 N N . LYS A 1 507 ? 39.979 -7.412 -9.396 1.00 25.08 ? 524 LYS A N 1 ATOM 4175 C CA . LYS A 1 507 ? 40.215 -8.861 -9.399 1.00 25.52 ? 524 LYS A CA 1 ATOM 4176 C C . LYS A 1 507 ? 40.965 -9.354 -10.648 1.00 26.00 ? 524 LYS A C 1 ATOM 4177 O O . LYS A 1 507 ? 41.707 -10.328 -10.578 1.00 24.80 ? 524 LYS A O 1 ATOM 4178 C CB . LYS A 1 507 ? 38.904 -9.632 -9.245 1.00 26.56 ? 524 LYS A CB 1 ATOM 4179 C CG . LYS A 1 507 ? 38.266 -9.488 -7.868 1.00 27.22 ? 524 LYS A CG 1 ATOM 4180 C CD . LYS A 1 507 ? 36.839 -10.020 -7.859 1.00 27.85 ? 524 LYS A CD 1 ATOM 4181 C CE . LYS A 1 507 ? 36.094 -9.625 -6.586 1.00 28.13 ? 524 LYS A CE 1 ATOM 4182 N NZ . LYS A 1 507 ? 36.800 -10.058 -5.349 1.00 28.75 ? 524 LYS A NZ 1 ATOM 4183 N N . ALA A 1 508 ? 40.761 -8.683 -11.782 1.00 25.41 ? 525 ALA A N 1 ATOM 4184 C CA . ALA A 1 508 ? 41.466 -8.999 -13.031 1.00 25.62 ? 525 ALA A CA 1 ATOM 4185 C C . ALA A 1 508 ? 42.875 -8.379 -13.157 1.00 26.10 ? 525 ALA A C 1 ATOM 4186 O O . ALA A 1 508 ? 43.553 -8.612 -14.162 1.00 25.93 ? 525 ALA A O 1 ATOM 4187 C CB . ALA A 1 508 ? 40.613 -8.557 -14.216 1.00 25.22 ? 525 ALA A CB 1 ATOM 4188 N N . GLY A 1 509 ? 43.307 -7.578 -12.181 1.00 26.71 ? 526 GLY A N 1 ATOM 4189 C CA . GLY A 1 509 ? 44.575 -6.843 -12.281 1.00 28.22 ? 526 GLY A CA 1 ATOM 4190 C C . GLY A 1 509 ? 44.533 -5.707 -13.297 1.00 29.94 ? 526 GLY A C 1 ATOM 4191 O O . GLY A 1 509 ? 45.573 -5.276 -13.804 1.00 28.83 ? 526 GLY A O 1 ATOM 4192 N N . GLN A 1 510 ? 43.327 -5.204 -13.575 1.00 29.50 ? 527 GLN A N 1 ATOM 4193 C CA . GLN A 1 510 ? 43.116 -4.186 -14.607 1.00 29.28 ? 527 GLN A CA 1 ATOM 4194 C C . GLN A 1 510 ? 42.870 -2.786 -14.065 1.00 28.75 ? 527 GLN A C 1 ATOM 4195 O O . GLN A 1 510 ? 42.744 -1.849 -14.848 1.00 29.17 ? 527 GLN A O 1 ATOM 4196 C CB . GLN A 1 510 ? 41.945 -4.605 -15.492 1.00 29.63 ? 527 GLN A CB 1 ATOM 4197 C CG . GLN A 1 510 ? 42.277 -5.758 -16.415 1.00 29.87 ? 527 GLN A CG 1 ATOM 4198 C CD . GLN A 1 510 ? 43.019 -5.317 -17.667 1.00 30.48 ? 527 GLN A CD 1 ATOM 4199 O OE1 . GLN A 1 510 ? 42.705 -4.281 -18.264 1.00 29.20 ? 527 GLN A OE1 1 ATOM 4200 N NE2 . GLN A 1 510 ? 44.000 -6.105 -18.075 1.00 31.23 ? 527 GLN A NE2 1 ATOM 4201 N N . TYR A 1 511 ? 42.791 -2.624 -12.745 1.00 27.89 ? 528 TYR A N 1 ATOM 4202 C CA . TYR A 1 511 ? 42.609 -1.306 -12.159 1.00 27.84 ? 528 TYR A CA 1 ATOM 4203 C C . TYR A 1 511 ? 43.439 -1.137 -10.894 1.00 29.27 ? 528 TYR A C 1 ATOM 4204 O O . TYR A 1 511 ? 43.411 -1.981 -10.008 1.00 27.90 ? 528 TYR A O 1 ATOM 4205 C CB . TYR A 1 511 ? 41.131 -1.042 -11.834 1.00 27.53 ? 528 TYR A CB 1 ATOM 4206 C CG . TYR A 1 511 ? 40.888 0.299 -11.171 1.00 27.51 ? 528 TYR A CG 1 ATOM 4207 C CD1 . TYR A 1 511 ? 41.378 1.476 -11.733 1.00 27.24 ? 528 TYR A CD1 1 ATOM 4208 C CD2 . TYR A 1 511 ? 40.182 0.395 -9.973 1.00 28.61 ? 528 TYR A CD2 1 ATOM 4209 C CE1 . TYR A 1 511 ? 41.169 2.701 -11.133 1.00 27.38 ? 528 TYR A CE1 1 ATOM 4210 C CE2 . TYR A 1 511 ? 39.964 1.621 -9.369 1.00 28.34 ? 528 TYR A CE2 1 ATOM 4211 C CZ . TYR A 1 511 ? 40.459 2.769 -9.954 1.00 28.31 ? 528 TYR A CZ 1 ATOM 4212 O OH . TYR A 1 511 ? 40.247 3.986 -9.356 1.00 28.63 ? 528 TYR A OH 1 ATOM 4213 N N . ASP A 1 512 ? 44.162 -0.028 -10.836 1.00 31.36 ? 529 ASP A N 1 ATOM 4214 C CA . ASP A 1 512 ? 44.879 0.392 -9.642 1.00 34.85 ? 529 ASP A CA 1 ATOM 4215 C C . ASP A 1 512 ? 44.829 1.914 -9.654 1.00 35.09 ? 529 ASP A C 1 ATOM 4216 O O . ASP A 1 512 ? 45.384 2.528 -10.565 1.00 36.41 ? 529 ASP A O 1 ATOM 4217 C CB . ASP A 1 512 ? 46.327 -0.118 -9.690 1.00 36.57 ? 529 ASP A CB 1 ATOM 4218 C CG . ASP A 1 512 ? 47.150 0.276 -8.456 1.00 38.33 ? 529 ASP A CG 1 ATOM 4219 O OD1 . ASP A 1 512 ? 46.835 1.281 -7.778 1.00 38.23 ? 529 ASP A OD1 1 ATOM 4220 O OD2 . ASP A 1 512 ? 48.138 -0.431 -8.175 1.00 39.99 ? 529 ASP A OD2 1 ATOM 4221 N N . PRO A 1 513 ? 44.180 2.532 -8.650 1.00 36.67 ? 530 PRO A N 1 ATOM 4222 C CA . PRO A 1 513 ? 44.066 3.992 -8.682 1.00 38.35 ? 530 PRO A CA 1 ATOM 4223 C C . PRO A 1 513 ? 45.416 4.726 -8.615 1.00 40.77 ? 530 PRO A C 1 ATOM 4224 O O . PRO A 1 513 ? 45.501 5.870 -9.062 1.00 40.92 ? 530 PRO A O 1 ATOM 4225 C CB . PRO A 1 513 ? 43.201 4.314 -7.456 1.00 38.02 ? 530 PRO A CB 1 ATOM 4226 C CG . PRO A 1 513 ? 43.346 3.149 -6.551 1.00 37.66 ? 530 PRO A CG 1 ATOM 4227 C CD . PRO A 1 513 ? 43.615 1.955 -7.415 1.00 37.41 ? 530 PRO A CD 1 ATOM 4228 N N . ASP A 1 514 ? 46.448 4.069 -8.077 1.00 43.12 ? 531 ASP A N 1 ATOM 4229 C CA . ASP A 1 514 ? 47.795 4.651 -7.984 1.00 45.63 ? 531 ASP A CA 1 ATOM 4230 C C . ASP A 1 514 ? 48.691 4.396 -9.207 1.00 45.43 ? 531 ASP A C 1 ATOM 4231 O O . ASP A 1 514 ? 49.791 4.947 -9.283 1.00 47.69 ? 531 ASP A O 1 ATOM 4232 C CB . ASP A 1 514 ? 48.493 4.144 -6.714 1.00 46.48 ? 531 ASP A CB 1 ATOM 4233 C CG . ASP A 1 514 ? 47.739 4.510 -5.445 1.00 48.27 ? 531 ASP A CG 1 ATOM 4234 O OD1 . ASP A 1 514 ? 47.067 5.562 -5.427 1.00 48.22 ? 531 ASP A OD1 1 ATOM 4235 O OD2 . ASP A 1 514 ? 47.821 3.744 -4.461 1.00 52.04 ? 531 ASP A OD2 1 ATOM 4236 N N . ASN A 1 515 ? 48.231 3.577 -10.152 1.00 43.96 ? 532 ASN A N 1 ATOM 4237 C CA . ASN A 1 515 ? 48.976 3.290 -11.372 1.00 42.06 ? 532 ASN A CA 1 ATOM 4238 C C . ASN A 1 515 ? 48.308 3.962 -12.572 1.00 42.97 ? 532 ASN A C 1 ATOM 4239 O O . ASN A 1 515 ? 47.188 3.612 -12.946 1.00 40.69 ? 532 ASN A O 1 ATOM 4240 C CB . ASN A 1 515 ? 49.061 1.777 -11.582 1.00 41.79 ? 532 ASN A CB 1 ATOM 4241 C CG . ASN A 1 515 ? 49.971 1.384 -12.733 1.00 41.16 ? 532 ASN A CG 1 ATOM 4242 O OD1 . ASN A 1 515 ? 50.324 2.202 -13.580 1.00 41.12 ? 532 ASN A OD1 1 ATOM 4243 N ND2 . ASN A 1 515 ? 50.339 0.112 -12.776 1.00 42.04 ? 532 ASN A ND2 1 ATOM 4244 N N . VAL A 1 516 ? 49.023 4.901 -13.191 1.00 41.23 ? 533 VAL A N 1 ATOM 4245 C CA . VAL A 1 516 ? 48.521 5.630 -14.361 1.00 42.30 ? 533 VAL A CA 1 ATOM 4246 C C . VAL A 1 516 ? 48.327 4.731 -15.603 1.00 40.69 ? 533 VAL A C 1 ATOM 4247 O O . VAL A 1 516 ? 47.583 5.090 -16.517 1.00 40.25 ? 533 VAL A O 1 ATOM 4248 C CB . VAL A 1 516 ? 49.435 6.849 -14.683 1.00 44.28 ? 533 VAL A CB 1 ATOM 4249 C CG1 . VAL A 1 516 ? 50.761 6.409 -15.309 1.00 43.98 ? 533 VAL A CG1 1 ATOM 4250 C CG2 . VAL A 1 516 ? 48.713 7.862 -15.567 1.00 44.91 ? 533 VAL A CG2 1 ATOM 4251 N N . GLU A 1 517 ? 48.993 3.573 -15.633 1.00 40.11 ? 534 GLU A N 1 ATOM 4252 C CA . GLU A 1 517 ? 48.802 2.595 -16.704 1.00 40.48 ? 534 GLU A CA 1 ATOM 4253 C C . GLU A 1 517 ? 47.530 1.744 -16.581 1.00 37.36 ? 534 GLU A C 1 ATOM 4254 O O . GLU A 1 517 ? 47.179 1.051 -17.536 1.00 35.82 ? 534 GLU A O 1 ATOM 4255 C CB . GLU A 1 517 ? 50.025 1.672 -16.814 1.00 44.96 ? 534 GLU A CB 1 ATOM 4256 C CG . GLU A 1 517 ? 51.320 2.394 -17.174 1.00 48.68 ? 534 GLU A CG 1 ATOM 4257 C CD . GLU A 1 517 ? 51.200 3.167 -18.477 1.00 53.16 ? 534 GLU A CD 1 ATOM 4258 O OE1 . GLU A 1 517 ? 50.870 2.539 -19.512 1.00 58.14 ? 534 GLU A OE1 1 ATOM 4259 O OE2 . GLU A 1 517 ? 51.406 4.402 -18.461 1.00 55.31 ? 534 GLU A OE2 1 ATOM 4260 N N . LEU A 1 518 ? 46.843 1.797 -15.437 1.00 32.99 ? 535 LEU A N 1 ATOM 4261 C CA . LEU A 1 518 ? 45.653 0.967 -15.196 1.00 32.23 ? 535 LEU A CA 1 ATOM 4262 C C . LEU A 1 518 ? 44.449 1.814 -14.757 1.00 30.49 ? 535 LEU A C 1 ATOM 4263 O O . LEU A 1 518 ? 43.918 1.611 -13.662 1.00 28.78 ? 535 LEU A O 1 ATOM 4264 C CB . LEU A 1 518 ? 45.975 -0.091 -14.131 1.00 32.83 ? 535 LEU A CB 1 ATOM 4265 C CG . LEU A 1 518 ? 47.059 -1.113 -14.484 1.00 33.12 ? 535 LEU A CG 1 ATOM 4266 C CD1 . LEU A 1 518 ? 47.417 -1.924 -13.246 1.00 34.49 ? 535 LEU A CD1 1 ATOM 4267 C CD2 . LEU A 1 518 ? 46.607 -2.021 -15.618 1.00 33.39 ? 535 LEU A CD2 1 ATOM 4268 N N . PRO A 1 519 ? 44.018 2.773 -15.603 1.00 28.38 ? 536 PRO A N 1 ATOM 4269 C CA . PRO A 1 519 ? 42.879 3.597 -15.239 1.00 27.90 ? 536 PRO A CA 1 ATOM 4270 C C . PRO A 1 519 ? 41.579 2.809 -15.388 1.00 25.95 ? 536 PRO A C 1 ATOM 4271 O O . PRO A 1 519 ? 41.482 1.933 -16.246 1.00 26.30 ? 536 PRO A O 1 ATOM 4272 C CB . PRO A 1 519 ? 42.941 4.727 -16.259 1.00 27.90 ? 536 PRO A CB 1 ATOM 4273 C CG . PRO A 1 519 ? 43.448 4.058 -17.483 1.00 28.62 ? 536 PRO A CG 1 ATOM 4274 C CD . PRO A 1 519 ? 44.444 3.041 -16.990 1.00 29.67 ? 536 PRO A CD 1 ATOM 4275 N N . LEU A 1 520 ? 40.586 3.133 -14.572 1.00 26.20 ? 537 LEU A N 1 ATOM 4276 C CA . LEU A 1 520 ? 39.335 2.369 -14.565 1.00 25.28 ? 537 LEU A CA 1 ATOM 4277 C C . LEU A 1 520 ? 38.645 2.389 -15.934 1.00 25.31 ? 537 LEU A C 1 ATOM 4278 O O . LEU A 1 520 ? 38.115 1.372 -16.383 1.00 24.60 ? 537 LEU A O 1 ATOM 4279 C CB . LEU A 1 520 ? 38.396 2.896 -13.482 1.00 25.51 ? 537 LEU A CB 1 ATOM 4280 C CG . LEU A 1 520 ? 37.140 2.075 -13.193 1.00 25.36 ? 537 LEU A CG 1 ATOM 4281 C CD1 . LEU A 1 520 ? 37.448 0.597 -12.984 1.00 25.00 ? 537 LEU A CD1 1 ATOM 4282 C CD2 . LEU A 1 520 ? 36.422 2.647 -11.981 1.00 25.77 ? 537 LEU A CD2 1 ATOM 4283 N N . ASP A 1 521 ? 38.708 3.530 -16.615 1.00 25.04 ? 538 ASP A N 1 ATOM 4284 C CA . ASP A 1 521 ? 38.080 3.693 -17.939 1.00 25.54 ? 538 ASP A CA 1 ATOM 4285 C C . ASP A 1 521 ? 38.774 2.976 -19.122 1.00 25.55 ? 538 ASP A C 1 ATOM 4286 O O . ASP A 1 521 ? 38.297 3.091 -20.241 1.00 25.15 ? 538 ASP A O 1 ATOM 4287 C CB . ASP A 1 521 ? 37.861 5.184 -18.272 1.00 26.72 ? 538 ASP A CB 1 ATOM 4288 C CG . ASP A 1 521 ? 39.137 6.015 -18.166 1.00 27.53 ? 538 ASP A CG 1 ATOM 4289 O OD1 . ASP A 1 521 ? 39.683 6.121 -17.047 1.00 27.95 ? 538 ASP A OD1 1 ATOM 4290 O OD2 . ASP A 1 521 ? 39.576 6.590 -19.181 1.00 28.68 ? 538 ASP A OD2 1 ATOM 4291 N N . ASN A 1 522 ? 39.882 2.262 -18.894 1.00 25.19 ? 539 ASN A N 1 ATOM 4292 C CA . ASN A 1 522 ? 40.450 1.366 -19.918 1.00 25.74 ? 539 ASN A CA 1 ATOM 4293 C C . ASN A 1 522 ? 40.597 -0.088 -19.456 1.00 25.16 ? 539 ASN A C 1 ATOM 4294 O O . ASN A 1 522 ? 41.391 -0.853 -20.011 1.00 25.43 ? 539 ASN A O 1 ATOM 4295 C CB . ASN A 1 522 ? 41.795 1.931 -20.427 1.00 27.21 ? 539 ASN A CB 1 ATOM 4296 C CG . ASN A 1 522 ? 42.102 1.546 -21.875 1.00 27.84 ? 539 ASN A CG 1 ATOM 4297 O OD1 . ASN A 1 522 ? 41.200 1.314 -22.685 1.00 26.77 ? 539 ASN A OD1 1 ATOM 4298 N ND2 . ASN A 1 522 ? 43.393 1.493 -22.208 1.00 28.91 ? 539 ASN A ND2 1 ATOM 4299 N N . CYS A 1 523 ? 39.802 -0.483 -18.460 1.00 24.38 ? 540 CYS A N 1 ATOM 4300 C CA . CYS A 1 523 ? 39.851 -1.842 -17.930 1.00 23.66 ? 540 CYS A CA 1 ATOM 4301 C C . CYS A 1 523 ? 39.141 -2.832 -18.848 1.00 24.27 ? 540 CYS A C 1 ATOM 4302 O O . CYS A 1 523 ? 38.015 -2.587 -19.293 1.00 23.90 ? 540 CYS A O 1 ATOM 4303 C CB . CYS A 1 523 ? 39.226 -1.904 -16.528 1.00 24.01 ? 540 CYS A CB 1 ATOM 4304 S SG . CYS A 1 523 ? 38.641 -3.549 -16.070 1.00 24.00 ? 540 CYS A SG 1 ATOM 4305 N N . ASP A 1 524 ? 39.798 -3.955 -19.126 1.00 23.96 ? 541 ASP A N 1 ATOM 4306 C CA . ASP A 1 524 ? 39.176 -5.037 -19.880 1.00 23.91 ? 541 ASP A CA 1 ATOM 4307 C C . ASP A 1 524 ? 39.262 -6.305 -19.052 1.00 24.21 ? 541 ASP A C 1 ATOM 4308 O O . ASP A 1 524 ? 40.358 -6.824 -18.822 1.00 25.01 ? 541 ASP A O 1 ATOM 4309 C CB . ASP A 1 524 ? 39.862 -5.226 -21.233 1.00 24.77 ? 541 ASP A CB 1 ATOM 4310 C CG . ASP A 1 524 ? 39.157 -6.241 -22.121 1.00 25.73 ? 541 ASP A CG 1 ATOM 4311 O OD1 . ASP A 1 524 ? 38.040 -6.718 -21.792 1.00 24.31 ? 541 ASP A OD1 1 ATOM 4312 O OD2 . ASP A 1 524 ? 39.730 -6.576 -23.183 1.00 26.24 ? 541 ASP A OD2 1 ATOM 4313 N N . ILE A 1 525 ? 38.104 -6.793 -18.611 1.00 23.05 ? 542 ILE A N 1 ATOM 4314 C CA . ILE A 1 525 ? 38.009 -8.019 -17.813 1.00 22.56 ? 542 ILE A CA 1 ATOM 4315 C C . ILE A 1 525 ? 37.926 -9.291 -18.660 1.00 22.65 ? 542 ILE A C 1 ATOM 4316 O O . ILE A 1 525 ? 37.812 -10.390 -18.115 1.00 22.63 ? 542 ILE A O 1 ATOM 4317 C CB . ILE A 1 525 ? 36.846 -7.963 -16.772 1.00 22.37 ? 542 ILE A CB 1 ATOM 4318 C CG1 . ILE A 1 525 ? 35.459 -7.883 -17.441 1.00 22.61 ? 542 ILE A CG1 1 ATOM 4319 C CG2 . ILE A 1 525 ? 37.047 -6.794 -15.826 1.00 22.57 ? 542 ILE A CG2 1 ATOM 4320 C CD1 . ILE A 1 525 ? 34.298 -7.960 -16.473 1.00 22.83 ? 542 ILE A CD1 1 ATOM 4321 N N . TYR A 1 526 ? 37.995 -9.158 -19.987 1.00 23.18 ? 543 TYR A N 1 ATOM 4322 C CA . TYR A 1 526 ? 38.109 -10.309 -20.873 1.00 23.98 ? 543 TYR A CA 1 ATOM 4323 C C . TYR A 1 526 ? 39.213 -11.257 -20.398 1.00 24.49 ? 543 TYR A C 1 ATOM 4324 O O . TYR A 1 526 ? 40.294 -10.810 -20.031 1.00 24.29 ? 543 TYR A O 1 ATOM 4325 C CB . TYR A 1 526 ? 38.392 -9.862 -22.317 1.00 24.16 ? 543 TYR A CB 1 ATOM 4326 C CG . TYR A 1 526 ? 38.385 -11.005 -23.297 1.00 24.53 ? 543 TYR A CG 1 ATOM 4327 C CD1 . TYR A 1 526 ? 39.540 -11.751 -23.539 1.00 24.41 ? 543 TYR A CD1 1 ATOM 4328 C CD2 . TYR A 1 526 ? 37.219 -11.358 -23.976 1.00 24.54 ? 543 TYR A CD2 1 ATOM 4329 C CE1 . TYR A 1 526 ? 39.536 -12.807 -24.432 1.00 25.97 ? 543 TYR A CE1 1 ATOM 4330 C CE2 . TYR A 1 526 ? 37.205 -12.415 -24.872 1.00 25.03 ? 543 TYR A CE2 1 ATOM 4331 C CZ . TYR A 1 526 ? 38.364 -13.136 -25.098 1.00 25.68 ? 543 TYR A CZ 1 ATOM 4332 O OH . TYR A 1 526 ? 38.357 -14.186 -25.977 1.00 26.56 ? 543 TYR A OH 1 ATOM 4333 N N . GLY A 1 527 ? 38.914 -12.552 -20.370 1.00 25.67 ? 544 GLY A N 1 ATOM 4334 C CA . GLY A 1 527 ? 39.896 -13.567 -19.980 1.00 26.34 ? 544 GLY A CA 1 ATOM 4335 C C . GLY A 1 527 ? 40.080 -13.807 -18.485 1.00 26.96 ? 544 GLY A C 1 ATOM 4336 O O . GLY A 1 527 ? 40.858 -14.686 -18.103 1.00 27.10 ? 544 GLY A O 1 ATOM 4337 N N . SER A 1 528 ? 39.371 -13.064 -17.630 1.00 25.83 ? 545 SER A N 1 ATOM 4338 C CA . SER A 1 528 ? 39.606 -13.130 -16.182 1.00 26.42 ? 545 SER A CA 1 ATOM 4339 C C . SER A 1 528 ? 38.698 -14.150 -15.513 1.00 26.95 ? 545 SER A C 1 ATOM 4340 O O . SER A 1 528 ? 37.504 -13.891 -15.304 1.00 25.91 ? 545 SER A O 1 ATOM 4341 C CB . SER A 1 528 ? 39.413 -11.767 -15.531 1.00 26.20 ? 545 SER A CB 1 ATOM 4342 O OG . SER A 1 528 ? 39.604 -11.848 -14.128 1.00 27.15 ? 545 SER A OG 1 ATOM 4343 N N . ALA A 1 529 ? 39.269 -15.304 -15.171 1.00 26.67 ? 546 ALA A N 1 ATOM 4344 C CA . ALA A 1 529 ? 38.546 -16.320 -14.402 1.00 27.58 ? 546 ALA A CA 1 ATOM 4345 C C . ALA A 1 529 ? 38.219 -15.808 -13.002 1.00 26.85 ? 546 ALA A C 1 ATOM 4346 O O . ALA A 1 529 ? 37.206 -16.200 -12.419 1.00 27.32 ? 546 ALA A O 1 ATOM 4347 C CB . ALA A 1 529 ? 39.342 -17.617 -14.324 1.00 28.02 ? 546 ALA A CB 1 ATOM 4348 N N . ALA A 1 530 ? 39.073 -14.937 -12.470 1.00 26.30 ? 547 ALA A N 1 ATOM 4349 C CA . ALA A 1 530 ? 38.840 -14.325 -11.163 1.00 26.71 ? 547 ALA A CA 1 ATOM 4350 C C . ALA A 1 530 ? 37.593 -13.435 -11.155 1.00 26.12 ? 547 ALA A C 1 ATOM 4351 O O . ALA A 1 530 ? 36.788 -13.500 -10.232 1.00 26.95 ? 547 ALA A O 1 ATOM 4352 C CB . ALA A 1 530 ? 40.063 -13.531 -10.726 1.00 27.41 ? 547 ALA A CB 1 ATOM 4353 N N . ALA A 1 531 ? 37.433 -12.602 -12.179 1.00 26.54 ? 548 ALA A N 1 ATOM 4354 C CA . ALA A 1 531 ? 36.207 -11.798 -12.323 1.00 25.09 ? 548 ALA A CA 1 ATOM 4355 C C . ALA A 1 531 ? 34.993 -12.713 -12.517 1.00 24.70 ? 548 ALA A C 1 ATOM 4356 O O . ALA A 1 531 ? 33.947 -12.500 -11.903 1.00 24.19 ? 548 ALA A O 1 ATOM 4357 C CB . ALA A 1 531 ? 36.338 -10.814 -13.476 1.00 24.74 ? 548 ALA A CB 1 ATOM 4358 N N . GLY A 1 532 ? 35.142 -13.749 -13.342 1.00 24.51 ? 549 GLY A N 1 ATOM 4359 C CA . GLY A 1 532 ? 34.072 -14.732 -13.544 1.00 24.43 ? 549 GLY A CA 1 ATOM 4360 C C . GLY A 1 532 ? 33.606 -15.427 -12.269 1.00 25.28 ? 549 GLY A C 1 ATOM 4361 O O . GLY A 1 532 ? 32.397 -15.623 -12.062 1.00 25.20 ? 549 GLY A O 1 ATOM 4362 N N . ALA A 1 533 ? 34.559 -15.787 -11.410 1.00 24.79 ? 550 ALA A N 1 ATOM 4363 C CA . ALA A 1 533 ? 34.244 -16.449 -10.140 1.00 24.87 ? 550 ALA A CA 1 ATOM 4364 C C . ALA A 1 533 ? 33.345 -15.577 -9.280 1.00 23.91 ? 550 ALA A C 1 ATOM 4365 O O . ALA A 1 533 ? 32.369 -16.067 -8.717 1.00 24.77 ? 550 ALA A O 1 ATOM 4366 C CB . ALA A 1 533 ? 35.521 -16.803 -9.382 1.00 24.66 ? 550 ALA A CB 1 ATOM 4367 N N . ALA A 1 534 ? 33.668 -14.288 -9.201 1.00 23.90 ? 551 ALA A N 1 ATOM 4368 C CA . ALA A 1 534 ? 32.860 -13.330 -8.457 1.00 23.67 ? 551 ALA A CA 1 ATOM 4369 C C . ALA A 1 534 ? 31.427 -13.273 -9.001 1.00 23.77 ? 551 ALA A C 1 ATOM 4370 O O . ALA A 1 534 ? 30.471 -13.286 -8.226 1.00 23.34 ? 551 ALA A O 1 ATOM 4371 C CB . ALA A 1 534 ? 33.504 -11.951 -8.483 1.00 23.86 ? 551 ALA A CB 1 ATOM 4372 N N . PHE A 1 535 ? 31.282 -13.220 -10.324 1.00 22.83 ? 552 PHE A N 1 ATOM 4373 C CA . PHE A 1 535 ? 29.961 -13.324 -10.957 1.00 23.07 ? 552 PHE A CA 1 ATOM 4374 C C . PHE A 1 535 ? 29.256 -14.636 -10.630 1.00 22.72 ? 552 PHE A C 1 ATOM 4375 O O . PHE A 1 535 ? 28.067 -14.643 -10.293 1.00 23.06 ? 552 PHE A O 1 ATOM 4376 C CB . PHE A 1 535 ? 30.050 -13.159 -12.486 1.00 23.92 ? 552 PHE A CB 1 ATOM 4377 C CG . PHE A 1 535 ? 30.103 -11.732 -12.929 1.00 25.03 ? 552 PHE A CG 1 ATOM 4378 C CD1 . PHE A 1 535 ? 28.950 -10.950 -12.902 1.00 26.32 ? 552 PHE A CD1 1 ATOM 4379 C CD2 . PHE A 1 535 ? 31.291 -11.153 -13.348 1.00 25.73 ? 552 PHE A CD2 1 ATOM 4380 C CE1 . PHE A 1 535 ? 28.983 -9.619 -13.291 1.00 26.96 ? 552 PHE A CE1 1 ATOM 4381 C CE2 . PHE A 1 535 ? 31.336 -9.824 -13.749 1.00 25.97 ? 552 PHE A CE2 1 ATOM 4382 C CZ . PHE A 1 535 ? 30.177 -9.055 -13.721 1.00 26.96 ? 552 PHE A CZ 1 ATOM 4383 N N . HIS A 1 536 ? 29.975 -15.745 -10.751 1.00 21.97 ? 553 HIS A N 1 ATOM 4384 C CA . HIS A 1 536 ? 29.387 -17.046 -10.443 1.00 22.13 ? 553 HIS A CA 1 ATOM 4385 C C . HIS A 1 536 ? 28.833 -17.078 -9.016 1.00 21.46 ? 553 HIS A C 1 ATOM 4386 O O . HIS A 1 536 ? 27.707 -17.512 -8.806 1.00 21.04 ? 553 HIS A O 1 ATOM 4387 C CB . HIS A 1 536 ? 30.383 -18.187 -10.642 1.00 22.42 ? 553 HIS A CB 1 ATOM 4388 C CG . HIS A 1 536 ? 29.902 -19.486 -10.083 1.00 23.73 ? 553 HIS A CG 1 ATOM 4389 N ND1 . HIS A 1 536 ? 28.791 -20.137 -10.576 1.00 23.63 ? 553 HIS A ND1 1 ATOM 4390 C CD2 . HIS A 1 536 ? 30.340 -20.225 -9.037 1.00 24.38 ? 553 HIS A CD2 1 ATOM 4391 C CE1 . HIS A 1 536 ? 28.581 -21.237 -9.873 1.00 24.51 ? 553 HIS A CE1 1 ATOM 4392 N NE2 . HIS A 1 536 ? 29.505 -21.312 -8.933 1.00 25.56 ? 553 HIS A NE2 1 ATOM 4393 N N . ASN A 1 537 ? 29.623 -16.598 -8.054 1.00 21.33 ? 554 ASN A N 1 ATOM 4394 C CA . ASN A 1 537 ? 29.222 -16.603 -6.645 1.00 21.68 ? 554 ASN A CA 1 ATOM 4395 C C . ASN A 1 537 ? 27.938 -15.810 -6.397 1.00 20.74 ? 554 ASN A C 1 ATOM 4396 O O . ASN A 1 537 ? 27.082 -16.242 -5.637 1.00 20.18 ? 554 ASN A O 1 ATOM 4397 C CB . ASN A 1 537 ? 30.335 -16.046 -5.756 1.00 23.25 ? 554 ASN A CB 1 ATOM 4398 C CG . ASN A 1 537 ? 31.588 -16.914 -5.760 1.00 24.84 ? 554 ASN A CG 1 ATOM 4399 O OD1 . ASN A 1 537 ? 31.529 -18.118 -6.008 1.00 26.31 ? 554 ASN A OD1 1 ATOM 4400 N ND2 . ASN A 1 537 ? 32.727 -16.296 -5.498 1.00 25.89 ? 554 ASN A ND2 1 ATOM 4401 N N . MET A 1 538 ? 27.819 -14.651 -7.044 1.00 20.17 ? 555 MET A N 1 ATOM 4402 C CA . MET A 1 538 ? 26.632 -13.792 -6.903 1.00 19.47 ? 555 MET A CA 1 ATOM 4403 C C . MET A 1 538 ? 25.429 -14.314 -7.695 1.00 19.04 ? 555 MET A C 1 ATOM 4404 O O . MET A 1 538 ? 24.314 -14.441 -7.161 1.00 19.12 ? 555 MET A O 1 ATOM 4405 C CB . MET A 1 538 ? 26.971 -12.379 -7.361 1.00 19.41 ? 555 MET A CB 1 ATOM 4406 C CG . MET A 1 538 ? 25.805 -11.406 -7.338 1.00 19.99 ? 555 MET A CG 1 ATOM 4407 S SD . MET A 1 538 ? 26.348 -9.758 -7.762 1.00 20.45 ? 555 MET A SD 1 ATOM 4408 C CE . MET A 1 538 ? 26.670 -9.911 -9.517 1.00 21.18 ? 555 MET A CE 1 ATOM 4409 N N . LEU A 1 539 ? 25.652 -14.583 -8.978 1.00 18.46 ? 556 LEU A N 1 ATOM 4410 C CA . LEU A 1 539 ? 24.569 -14.923 -9.888 1.00 18.47 ? 556 LEU A CA 1 ATOM 4411 C C . LEU A 1 539 ? 23.919 -16.267 -9.571 1.00 18.50 ? 556 LEU A C 1 ATOM 4412 O O . LEU A 1 539 ? 22.704 -16.408 -9.720 1.00 17.15 ? 556 LEU A O 1 ATOM 4413 C CB . LEU A 1 539 ? 25.050 -14.903 -11.342 1.00 18.63 ? 556 LEU A CB 1 ATOM 4414 C CG . LEU A 1 539 ? 25.596 -13.565 -11.865 1.00 19.00 ? 556 LEU A CG 1 ATOM 4415 C CD1 . LEU A 1 539 ? 25.919 -13.706 -13.344 1.00 19.95 ? 556 LEU A CD1 1 ATOM 4416 C CD2 . LEU A 1 539 ? 24.644 -12.407 -11.617 1.00 19.25 ? 556 LEU A CD2 1 ATOM 4417 N N . SER A 1 540 ? 24.714 -17.235 -9.106 1.00 18.64 ? 557 SER A N 1 ATOM 4418 C CA . SER A 1 540 ? 24.175 -18.561 -8.774 1.00 19.51 ? 557 SER A CA 1 ATOM 4419 C C . SER A 1 540 ? 23.159 -18.529 -7.626 1.00 18.92 ? 557 SER A C 1 ATOM 4420 O O . SER A 1 540 ? 22.381 -19.455 -7.484 1.00 19.65 ? 557 SER A O 1 ATOM 4421 C CB . SER A 1 540 ? 25.299 -19.561 -8.454 1.00 20.42 ? 557 SER A CB 1 ATOM 4422 O OG . SER A 1 540 ? 26.047 -19.147 -7.331 1.00 21.93 ? 557 SER A OG 1 ATOM 4423 N N . MET A 1 541 ? 23.167 -17.467 -6.827 1.00 18.24 ? 558 MET A N 1 ATOM 4424 C CA . MET A 1 541 ? 22.238 -17.330 -5.706 1.00 18.25 ? 558 MET A CA 1 ATOM 4425 C C . MET A 1 541 ? 20.815 -16.991 -6.110 1.00 17.09 ? 558 MET A C 1 ATOM 4426 O O . MET A 1 541 ? 19.904 -17.202 -5.332 1.00 16.26 ? 558 MET A O 1 ATOM 4427 C CB . MET A 1 541 ? 22.738 -16.264 -4.731 1.00 18.60 ? 558 MET A CB 1 ATOM 4428 C CG . MET A 1 541 ? 24.056 -16.645 -4.062 1.00 19.52 ? 558 MET A CG 1 ATOM 4429 S SD . MET A 1 541 ? 24.739 -15.276 -3.125 1.00 20.12 ? 558 MET A SD 1 ATOM 4430 C CE . MET A 1 541 ? 23.415 -15.019 -1.945 1.00 20.30 ? 558 MET A CE 1 ATOM 4431 N N . GLY A 1 542 ? 20.611 -16.459 -7.314 1.00 16.94 ? 559 GLY A N 1 ATOM 4432 C CA . GLY A 1 542 ? 19.290 -15.999 -7.712 1.00 16.25 ? 559 GLY A CA 1 ATOM 4433 C C . GLY A 1 542 ? 18.726 -15.050 -6.670 1.00 16.11 ? 559 GLY A C 1 ATOM 4434 O O . GLY A 1 542 ? 19.448 -14.166 -6.174 1.00 16.54 ? 559 GLY A O 1 ATOM 4435 N N . ALA A 1 543 ? 17.455 -15.250 -6.329 1.00 15.56 ? 560 ALA A N 1 ATOM 4436 C CA . ALA A 1 543 ? 16.774 -14.495 -5.275 1.00 16.35 ? 560 ALA A CA 1 ATOM 4437 C C . ALA A 1 543 ? 16.651 -15.252 -3.943 1.00 16.38 ? 560 ALA A C 1 ATOM 4438 O O . ALA A 1 543 ? 15.764 -14.933 -3.129 1.00 16.75 ? 560 ALA A O 1 ATOM 4439 C CB . ALA A 1 543 ? 15.402 -14.083 -5.765 1.00 16.24 ? 560 ALA A CB 1 ATOM 4440 N N . SER A 1 544 ? 17.532 -16.233 -3.718 1.00 16.72 ? 561 SER A N 1 ATOM 4441 C CA . SER A 1 544 ? 17.522 -17.041 -2.492 1.00 17.08 ? 561 SER A CA 1 ATOM 4442 C C . SER A 1 544 ? 17.804 -16.242 -1.236 1.00 17.91 ? 561 SER A C 1 ATOM 4443 O O . SER A 1 544 ? 17.397 -16.657 -0.145 1.00 17.55 ? 561 SER A O 1 ATOM 4444 C CB . SER A 1 544 ? 18.513 -18.217 -2.578 1.00 16.80 ? 561 SER A CB 1 ATOM 4445 O OG . SER A 1 544 ? 19.847 -17.778 -2.802 1.00 16.33 ? 561 SER A OG 1 ATOM 4446 N N . LYS A 1 545 ? 18.500 -15.117 -1.380 1.00 18.39 ? 562 LYS A N 1 ATOM 4447 C CA . LYS A 1 545 ? 18.815 -14.238 -0.263 1.00 20.25 ? 562 LYS A CA 1 ATOM 4448 C C . LYS A 1 545 ? 18.539 -12.777 -0.651 1.00 19.46 ? 562 LYS A C 1 ATOM 4449 O O . LYS A 1 545 ? 18.567 -12.440 -1.839 1.00 19.30 ? 562 LYS A O 1 ATOM 4450 C CB . LYS A 1 545 ? 20.301 -14.368 0.099 1.00 22.23 ? 562 LYS A CB 1 ATOM 4451 C CG . LYS A 1 545 ? 20.756 -15.747 0.547 1.00 24.69 ? 562 LYS A CG 1 ATOM 4452 C CD . LYS A 1 545 ? 20.253 -16.112 1.934 1.00 29.09 ? 562 LYS A CD 1 ATOM 4453 C CE . LYS A 1 545 ? 21.311 -16.906 2.696 1.00 32.97 ? 562 LYS A CE 1 ATOM 4454 N NZ . LYS A 1 545 ? 20.767 -17.635 3.880 1.00 35.46 ? 562 LYS A NZ 1 ATOM 4455 N N . PRO A 1 546 ? 18.317 -11.895 0.344 1.00 18.72 ? 563 PRO A N 1 ATOM 4456 C CA . PRO A 1 546 ? 18.213 -10.473 0.014 1.00 18.09 ? 563 PRO A CA 1 ATOM 4457 C C . PRO A 1 546 ? 19.449 -9.966 -0.729 1.00 17.38 ? 563 PRO A C 1 ATOM 4458 O O . PRO A 1 546 ? 20.551 -10.489 -0.536 1.00 17.78 ? 563 PRO A O 1 ATOM 4459 C CB . PRO A 1 546 ? 18.065 -9.808 1.381 1.00 18.60 ? 563 PRO A CB 1 ATOM 4460 C CG . PRO A 1 546 ? 17.423 -10.856 2.232 1.00 18.84 ? 563 PRO A CG 1 ATOM 4461 C CD . PRO A 1 546 ? 18.066 -12.138 1.781 1.00 19.14 ? 563 PRO A CD 1 ATOM 4462 N N . TRP A 1 547 ? 19.260 -8.962 -1.579 1.00 17.09 ? 564 TRP A N 1 ATOM 4463 C CA . TRP A 1 547 ? 20.314 -8.527 -2.490 1.00 16.70 ? 564 TRP A CA 1 ATOM 4464 C C . TRP A 1 547 ? 21.652 -8.144 -1.841 1.00 17.20 ? 564 TRP A C 1 ATOM 4465 O O . TRP A 1 547 ? 22.695 -8.398 -2.442 1.00 17.15 ? 564 TRP A O 1 ATOM 4466 C CB . TRP A 1 547 ? 19.822 -7.445 -3.459 1.00 16.18 ? 564 TRP A CB 1 ATOM 4467 C CG . TRP A 1 547 ? 19.497 -6.136 -2.836 1.00 16.19 ? 564 TRP A CG 1 ATOM 4468 C CD1 . TRP A 1 547 ? 18.273 -5.697 -2.457 1.00 16.27 ? 564 TRP A CD1 1 ATOM 4469 C CD2 . TRP A 1 547 ? 20.418 -5.094 -2.506 1.00 16.30 ? 564 TRP A CD2 1 ATOM 4470 N NE1 . TRP A 1 547 ? 18.358 -4.442 -1.919 1.00 16.54 ? 564 TRP A NE1 1 ATOM 4471 C CE2 . TRP A 1 547 ? 19.669 -4.043 -1.936 1.00 16.38 ? 564 TRP A CE2 1 ATOM 4472 C CE3 . TRP A 1 547 ? 21.797 -4.945 -2.635 1.00 16.22 ? 564 TRP A CE3 1 ATOM 4473 C CZ2 . TRP A 1 547 ? 20.254 -2.863 -1.489 1.00 16.32 ? 564 TRP A CZ2 1 ATOM 4474 C CZ3 . TRP A 1 547 ? 22.381 -3.766 -2.179 1.00 16.77 ? 564 TRP A CZ3 1 ATOM 4475 C CH2 . TRP A 1 547 ? 21.611 -2.746 -1.619 1.00 16.38 ? 564 TRP A CH2 1 ATOM 4476 N N . PRO A 1 548 ? 21.643 -7.557 -0.620 1.00 17.59 ? 565 PRO A N 1 ATOM 4477 C CA . PRO A 1 548 ? 22.962 -7.268 -0.036 1.00 17.75 ? 565 PRO A CA 1 ATOM 4478 C C . PRO A 1 548 ? 23.847 -8.508 0.162 1.00 17.82 ? 565 PRO A C 1 ATOM 4479 O O . PRO A 1 548 ? 25.074 -8.395 0.084 1.00 17.00 ? 565 PRO A O 1 ATOM 4480 C CB . PRO A 1 548 ? 22.618 -6.604 1.300 1.00 17.91 ? 565 PRO A CB 1 ATOM 4481 C CG . PRO A 1 548 ? 21.261 -6.027 1.085 1.00 18.22 ? 565 PRO A CG 1 ATOM 4482 C CD . PRO A 1 548 ? 20.563 -7.054 0.253 1.00 17.93 ? 565 PRO A CD 1 ATOM 4483 N N . ASP A 1 549 ? 23.230 -9.670 0.388 1.00 18.17 ? 566 ASP A N 1 ATOM 4484 C CA . ASP A 1 549 ? 23.961 -10.939 0.434 1.00 19.23 ? 566 ASP A CA 1 ATOM 4485 C C . ASP A 1 549 ? 24.535 -11.359 -0.921 1.00 18.62 ? 566 ASP A C 1 ATOM 4486 O O . ASP A 1 549 ? 25.596 -11.975 -0.982 1.00 18.32 ? 566 ASP A O 1 ATOM 4487 C CB . ASP A 1 549 ? 23.077 -12.072 0.985 1.00 19.68 ? 566 ASP A CB 1 ATOM 4488 C CG . ASP A 1 549 ? 22.659 -11.846 2.429 1.00 21.66 ? 566 ASP A CG 1 ATOM 4489 O OD1 . ASP A 1 549 ? 23.531 -11.503 3.256 1.00 22.16 ? 566 ASP A OD1 1 ATOM 4490 O OD2 . ASP A 1 549 ? 21.456 -12.008 2.729 1.00 22.39 ? 566 ASP A OD2 1 ATOM 4491 N N . ALA A 1 550 ? 23.812 -11.071 -2.002 1.00 18.52 ? 567 ALA A N 1 ATOM 4492 C CA . ALA A 1 550 ? 24.302 -11.346 -3.345 1.00 18.28 ? 567 ALA A CA 1 ATOM 4493 C C . ALA A 1 550 ? 25.483 -10.422 -3.679 1.00 18.17 ? 567 ALA A C 1 ATOM 4494 O O . ALA A 1 550 ? 26.509 -10.878 -4.187 1.00 18.18 ? 567 ALA A O 1 ATOM 4495 C CB . ALA A 1 550 ? 23.179 -11.187 -4.363 1.00 18.30 ? 567 ALA A CB 1 ATOM 4496 N N . LEU A 1 551 ? 25.351 -9.132 -3.370 1.00 18.22 ? 568 LEU A N 1 ATOM 4497 C CA . LEU A 1 551 ? 26.469 -8.199 -3.543 1.00 18.21 ? 568 LEU A CA 1 ATOM 4498 C C . LEU A 1 551 ? 27.688 -8.661 -2.736 1.00 18.20 ? 568 LEU A C 1 ATOM 4499 O O . LEU A 1 551 ? 28.820 -8.665 -3.245 1.00 16.97 ? 568 LEU A O 1 ATOM 4500 C CB . LEU A 1 551 ? 26.080 -6.773 -3.134 1.00 18.54 ? 568 LEU A CB 1 ATOM 4501 C CG . LEU A 1 551 ? 27.145 -5.664 -3.265 1.00 19.05 ? 568 LEU A CG 1 ATOM 4502 C CD1 . LEU A 1 551 ? 27.686 -5.544 -4.676 1.00 19.53 ? 568 LEU A CD1 1 ATOM 4503 C CD2 . LEU A 1 551 ? 26.553 -4.339 -2.815 1.00 18.80 ? 568 LEU A CD2 1 ATOM 4504 N N . GLU A 1 552 ? 27.444 -9.083 -1.498 1.00 18.33 ? 569 GLU A N 1 ATOM 4505 C CA . GLU A 1 552 ? 28.541 -9.477 -0.614 1.00 19.35 ? 569 GLU A CA 1 ATOM 4506 C C . GLU A 1 552 ? 29.292 -10.685 -1.159 1.00 19.34 ? 569 GLU A C 1 ATOM 4507 O O . GLU A 1 552 ? 30.509 -10.752 -1.032 1.00 19.84 ? 569 GLU A O 1 ATOM 4508 C CB . GLU A 1 552 ? 28.048 -9.725 0.813 1.00 19.69 ? 569 GLU A CB 1 ATOM 4509 C CG . GLU A 1 552 ? 29.153 -9.615 1.849 1.00 19.90 ? 569 GLU A CG 1 ATOM 4510 C CD . GLU A 1 552 ? 28.663 -9.767 3.275 1.00 20.74 ? 569 GLU A CD 1 ATOM 4511 O OE1 . GLU A 1 552 ? 27.524 -10.232 3.499 1.00 19.82 ? 569 GLU A OE1 1 ATOM 4512 O OE2 . GLU A 1 552 ? 29.426 -9.393 4.183 1.00 21.93 ? 569 GLU A OE2 1 ATOM 4513 N N . ALA A 1 553 ? 28.574 -11.608 -1.797 1.00 19.92 ? 570 ALA A N 1 ATOM 4514 C CA . ALA A 1 553 ? 29.185 -12.758 -2.451 1.00 21.08 ? 570 ALA A CA 1 ATOM 4515 C C . ALA A 1 553 ? 30.114 -12.354 -3.600 1.00 21.12 ? 570 ALA A C 1 ATOM 4516 O O . ALA A 1 553 ? 31.082 -13.060 -3.880 1.00 21.28 ? 570 ALA A O 1 ATOM 4517 C CB . ALA A 1 553 ? 28.115 -13.721 -2.955 1.00 21.52 ? 570 ALA A CB 1 ATOM 4518 N N . PHE A 1 554 ? 29.815 -11.229 -4.247 1.00 20.84 ? 571 PHE A N 1 ATOM 4519 C CA . PHE A 1 554 ? 30.632 -10.687 -5.337 1.00 21.61 ? 571 PHE A CA 1 ATOM 4520 C C . PHE A 1 554 ? 31.921 -10.029 -4.848 1.00 21.58 ? 571 PHE A C 1 ATOM 4521 O O . PHE A 1 554 ? 33.001 -10.389 -5.298 1.00 21.33 ? 571 PHE A O 1 ATOM 4522 C CB . PHE A 1 554 ? 29.823 -9.678 -6.150 1.00 22.18 ? 571 PHE A CB 1 ATOM 4523 C CG . PHE A 1 554 ? 30.440 -9.321 -7.470 1.00 23.15 ? 571 PHE A CG 1 ATOM 4524 C CD1 . PHE A 1 554 ? 30.143 -10.053 -8.610 1.00 23.64 ? 571 PHE A CD1 1 ATOM 4525 C CD2 . PHE A 1 554 ? 31.298 -8.231 -7.582 1.00 23.80 ? 571 PHE A CD2 1 ATOM 4526 C CE1 . PHE A 1 554 ? 30.703 -9.718 -9.831 1.00 23.92 ? 571 PHE A CE1 1 ATOM 4527 C CE2 . PHE A 1 554 ? 31.853 -7.894 -8.796 1.00 24.09 ? 571 PHE A CE2 1 ATOM 4528 C CZ . PHE A 1 554 ? 31.561 -8.640 -9.921 1.00 23.84 ? 571 PHE A CZ 1 ATOM 4529 N N . ASN A 1 555 ? 31.806 -9.050 -3.956 1.00 20.66 ? 572 ASN A N 1 ATOM 4530 C CA . ASN A 1 555 ? 32.971 -8.251 -3.547 1.00 20.83 ? 572 ASN A CA 1 ATOM 4531 C C . ASN A 1 555 ? 33.036 -7.875 -2.068 1.00 20.24 ? 572 ASN A C 1 ATOM 4532 O O . ASN A 1 555 ? 33.737 -6.939 -1.701 1.00 19.28 ? 572 ASN A O 1 ATOM 4533 C CB . ASN A 1 555 ? 33.045 -6.978 -4.400 1.00 21.00 ? 572 ASN A CB 1 ATOM 4534 C CG . ASN A 1 555 ? 31.829 -6.072 -4.229 1.00 21.48 ? 572 ASN A CG 1 ATOM 4535 O OD1 . ASN A 1 555 ? 30.981 -6.283 -3.370 1.00 19.99 ? 572 ASN A OD1 1 ATOM 4536 N ND2 . ASN A 1 555 ? 31.746 -5.059 -5.067 1.00 22.58 ? 572 ASN A ND2 1 ATOM 4537 N N . GLY A 1 556 ? 32.283 -8.575 -1.226 1.00 20.40 ? 573 GLY A N 1 ATOM 4538 C CA . GLY A 1 556 ? 32.212 -8.244 0.200 1.00 20.66 ? 573 GLY A CA 1 ATOM 4539 C C . GLY A 1 556 ? 31.407 -7.010 0.593 1.00 21.06 ? 573 GLY A C 1 ATOM 4540 O O . GLY A 1 556 ? 31.258 -6.753 1.786 1.00 20.50 ? 573 GLY A O 1 ATOM 4541 N N . GLU A 1 557 ? 30.882 -6.248 -0.370 1.00 20.73 ? 574 GLU A N 1 ATOM 4542 C CA . GLU A 1 557 ? 30.112 -5.042 -0.053 1.00 21.52 ? 574 GLU A CA 1 ATOM 4543 C C . GLU A 1 557 ? 28.667 -5.427 0.224 1.00 20.58 ? 574 GLU A C 1 ATOM 4544 O O . GLU A 1 557 ? 28.193 -6.442 -0.253 1.00 19.19 ? 574 GLU A O 1 ATOM 4545 C CB . GLU A 1 557 ? 30.140 -4.043 -1.211 1.00 23.93 ? 574 GLU A CB 1 ATOM 4546 C CG . GLU A 1 557 ? 31.520 -3.525 -1.565 1.00 26.53 ? 574 GLU A CG 1 ATOM 4547 C CD . GLU A 1 557 ? 31.461 -2.488 -2.669 1.00 29.30 ? 574 GLU A CD 1 ATOM 4548 O OE1 . GLU A 1 557 ? 30.828 -2.751 -3.719 1.00 30.56 ? 574 GLU A OE1 1 ATOM 4549 O OE2 . GLU A 1 557 ? 32.032 -1.397 -2.474 1.00 36.43 ? 574 GLU A OE2 1 ATOM 4550 N N . ARG A 1 558 ? 27.977 -4.626 1.022 1.00 19.97 ? 575 ARG A N 1 ATOM 4551 C CA . ARG A 1 558 ? 26.544 -4.816 1.234 1.00 20.64 ? 575 ARG A CA 1 ATOM 4552 C C . ARG A 1 558 ? 25.722 -3.582 0.889 1.00 20.81 ? 575 ARG A C 1 ATOM 4553 O O . ARG A 1 558 ? 24.495 -3.643 0.892 1.00 21.68 ? 575 ARG A O 1 ATOM 4554 C CB . ARG A 1 558 ? 26.294 -5.219 2.684 1.00 20.52 ? 575 ARG A CB 1 ATOM 4555 C CG . ARG A 1 558 ? 26.893 -6.558 3.060 1.00 20.75 ? 575 ARG A CG 1 ATOM 4556 C CD . ARG A 1 558 ? 26.581 -6.908 4.511 1.00 21.29 ? 575 ARG A CD 1 ATOM 4557 N NE . ARG A 1 558 ? 25.141 -6.977 4.761 1.00 21.01 ? 575 ARG A NE 1 ATOM 4558 C CZ . ARG A 1 558 ? 24.346 -8.008 4.452 1.00 21.20 ? 575 ARG A CZ 1 ATOM 4559 N NH1 . ARG A 1 558 ? 24.826 -9.112 3.875 1.00 21.32 ? 575 ARG A NH1 1 ATOM 4560 N NH2 . ARG A 1 558 ? 23.046 -7.932 4.729 1.00 21.68 ? 575 ARG A NH2 1 ATOM 4561 N N . ILE A 1 559 ? 26.389 -2.477 0.566 1.00 21.00 ? 576 ILE A N 1 ATOM 4562 C CA . ILE A 1 559 ? 25.730 -1.195 0.418 1.00 22.26 ? 576 ILE A CA 1 ATOM 4563 C C . ILE A 1 559 ? 25.827 -0.722 -1.033 1.00 21.53 ? 576 ILE A C 1 ATOM 4564 O O . ILE A 1 559 ? 26.892 -0.768 -1.646 1.00 20.04 ? 576 ILE A O 1 ATOM 4565 C CB . ILE A 1 559 ? 26.323 -0.164 1.401 1.00 24.27 ? 576 ILE A CB 1 ATOM 4566 C CG1 . ILE A 1 559 ? 25.987 -0.607 2.829 1.00 26.01 ? 576 ILE A CG1 1 ATOM 4567 C CG2 . ILE A 1 559 ? 25.759 1.237 1.144 1.00 25.05 ? 576 ILE A CG2 1 ATOM 4568 C CD1 . ILE A 1 559 ? 26.708 0.162 3.897 1.00 28.12 ? 576 ILE A CD1 1 ATOM 4569 N N . MET A 1 560 ? 24.693 -0.284 -1.566 1.00 21.60 ? 577 MET A N 1 ATOM 4570 C CA . MET A 1 560 ? 24.636 0.354 -2.874 1.00 22.05 ? 577 MET A CA 1 ATOM 4571 C C . MET A 1 560 ? 25.275 1.739 -2.735 1.00 22.47 ? 577 MET A C 1 ATOM 4572 O O . MET A 1 560 ? 24.932 2.499 -1.832 1.00 22.63 ? 577 MET A O 1 ATOM 4573 C CB . MET A 1 560 ? 23.179 0.476 -3.321 1.00 22.21 ? 577 MET A CB 1 ATOM 4574 C CG . MET A 1 560 ? 22.970 1.133 -4.667 1.00 22.90 ? 577 MET A CG 1 ATOM 4575 S SD . MET A 1 560 ? 21.255 0.981 -5.195 1.00 22.85 ? 577 MET A SD 1 ATOM 4576 C CE . MET A 1 560 ? 20.424 1.946 -3.932 1.00 23.27 ? 577 MET A CE 1 ATOM 4577 N N . SER A 1 561 ? 26.200 2.056 -3.633 1.00 21.58 ? 578 SER A N 1 ATOM 4578 C CA . SER A 1 561 ? 27.040 3.252 -3.504 1.00 22.24 ? 578 SER A CA 1 ATOM 4579 C C . SER A 1 561 ? 27.338 3.844 -4.874 1.00 22.21 ? 578 SER A C 1 ATOM 4580 O O . SER A 1 561 ? 27.611 3.110 -5.813 1.00 22.07 ? 578 SER A O 1 ATOM 4581 C CB . SER A 1 561 ? 28.358 2.899 -2.802 1.00 22.16 ? 578 SER A CB 1 ATOM 4582 O OG . SER A 1 561 ? 29.262 3.996 -2.805 1.00 22.99 ? 578 SER A OG 1 ATOM 4583 N N . GLY A 1 562 ? 27.298 5.174 -4.964 1.00 23.46 ? 579 GLY A N 1 ATOM 4584 C CA . GLY A 1 562 ? 27.750 5.901 -6.148 1.00 23.99 ? 579 GLY A CA 1 ATOM 4585 C C . GLY A 1 562 ? 29.229 6.273 -6.165 1.00 24.65 ? 579 GLY A C 1 ATOM 4586 O O . GLY A 1 562 ? 29.649 7.062 -7.008 1.00 23.13 ? 579 GLY A O 1 ATOM 4587 N N . LYS A 1 563 ? 30.029 5.731 -5.247 1.00 25.33 ? 580 LYS A N 1 ATOM 4588 C CA . LYS A 1 563 ? 31.471 6.019 -5.245 1.00 26.65 ? 580 LYS A CA 1 ATOM 4589 C C . LYS A 1 563 ? 32.144 5.598 -6.549 1.00 24.53 ? 580 LYS A C 1 ATOM 4590 O O . LYS A 1 563 ? 32.889 6.377 -7.144 1.00 22.81 ? 580 LYS A O 1 ATOM 4591 C CB . LYS A 1 563 ? 32.172 5.338 -4.064 1.00 30.12 ? 580 LYS A CB 1 ATOM 4592 C CG . LYS A 1 563 ? 31.828 5.973 -2.727 1.00 35.17 ? 580 LYS A CG 1 ATOM 4593 C CD . LYS A 1 563 ? 32.704 7.185 -2.415 1.00 39.88 ? 580 LYS A CD 1 ATOM 4594 C CE . LYS A 1 563 ? 33.801 6.853 -1.406 1.00 43.88 ? 580 LYS A CE 1 ATOM 4595 N NZ . LYS A 1 563 ? 34.682 5.722 -1.829 1.00 46.44 ? 580 LYS A NZ 1 ATOM 4596 N N . ALA A 1 564 ? 31.849 4.379 -6.992 1.00 22.34 ? 581 ALA A N 1 ATOM 4597 C CA . ALA A 1 564 ? 32.479 3.797 -8.172 1.00 22.12 ? 581 ALA A CA 1 ATOM 4598 C C . ALA A 1 564 ? 32.188 4.574 -9.448 1.00 21.91 ? 581 ALA A C 1 ATOM 4599 O O . ALA A 1 564 ? 33.108 4.845 -10.238 1.00 22.17 ? 581 ALA A O 1 ATOM 4600 C CB . ALA A 1 564 ? 32.053 2.346 -8.339 1.00 21.97 ? 581 ALA A CB 1 ATOM 4601 N N . ILE A 1 565 ? 30.918 4.923 -9.667 1.00 20.72 ? 582 ILE A N 1 ATOM 4602 C CA . ILE A 1 565 ? 30.560 5.696 -10.857 1.00 20.94 ? 582 ILE A CA 1 ATOM 4603 C C . ILE A 1 565 ? 31.197 7.104 -10.823 1.00 21.46 ? 582 ILE A C 1 ATOM 4604 O O . ILE A 1 565 ? 31.705 7.563 -11.842 1.00 21.96 ? 582 ILE A O 1 ATOM 4605 C CB . ILE A 1 565 ? 29.029 5.728 -11.123 1.00 19.94 ? 582 ILE A CB 1 ATOM 4606 C CG1 . ILE A 1 565 ? 28.736 6.265 -12.531 1.00 20.19 ? 582 ILE A CG1 1 ATOM 4607 C CG2 . ILE A 1 565 ? 28.290 6.524 -10.063 1.00 20.22 ? 582 ILE A CG2 1 ATOM 4608 C CD1 . ILE A 1 565 ? 27.267 6.270 -12.887 1.00 20.29 ? 582 ILE A CD1 1 ATOM 4609 N N . ALA A 1 566 ? 31.205 7.766 -9.667 1.00 21.83 ? 583 ALA A N 1 ATOM 4610 C CA . ALA A 1 566 ? 31.915 9.049 -9.537 1.00 23.07 ? 583 ALA A CA 1 ATOM 4611 C C . ALA A 1 566 ? 33.418 8.911 -9.827 1.00 23.89 ? 583 ALA A C 1 ATOM 4612 O O . ALA A 1 566 ? 34.000 9.734 -10.532 1.00 24.51 ? 583 ALA A O 1 ATOM 4613 C CB . ALA A 1 566 ? 31.695 9.653 -8.160 1.00 23.24 ? 583 ALA A CB 1 ATOM 4614 N N . GLU A 1 567 ? 34.021 7.854 -9.296 1.00 24.48 ? 584 GLU A N 1 ATOM 4615 C CA . GLU A 1 567 ? 35.441 7.558 -9.491 1.00 25.69 ? 584 GLU A CA 1 ATOM 4616 C C . GLU A 1 567 ? 35.778 7.379 -10.974 1.00 24.58 ? 584 GLU A C 1 ATOM 4617 O O . GLU A 1 567 ? 36.744 7.953 -11.480 1.00 22.92 ? 584 GLU A O 1 ATOM 4618 C CB . GLU A 1 567 ? 35.777 6.297 -8.701 1.00 28.40 ? 584 GLU A CB 1 ATOM 4619 C CG . GLU A 1 567 ? 37.235 5.981 -8.475 1.00 31.11 ? 584 GLU A CG 1 ATOM 4620 C CD . GLU A 1 567 ? 37.396 4.755 -7.577 1.00 34.17 ? 584 GLU A CD 1 ATOM 4621 O OE1 . GLU A 1 567 ? 36.537 4.538 -6.692 1.00 33.62 ? 584 GLU A OE1 1 ATOM 4622 O OE2 . GLU A 1 567 ? 38.369 3.995 -7.761 1.00 37.80 ? 584 GLU A OE2 1 ATOM 4623 N N . TYR A 1 568 ? 34.944 6.610 -11.670 1.00 22.51 ? 585 TYR A N 1 ATOM 4624 C CA . TYR A 1 568 ? 35.089 6.405 -13.107 1.00 21.65 ? 585 TYR A CA 1 ATOM 4625 C C . TYR A 1 568 ? 35.169 7.726 -13.879 1.00 21.03 ? 585 TYR A C 1 ATOM 4626 O O . TYR A 1 568 ? 36.031 7.884 -14.732 1.00 20.32 ? 585 TYR A O 1 ATOM 4627 C CB . TYR A 1 568 ? 33.928 5.550 -13.635 1.00 20.72 ? 585 TYR A CB 1 ATOM 4628 C CG . TYR A 1 568 ? 34.070 5.077 -15.066 1.00 20.31 ? 585 TYR A CG 1 ATOM 4629 C CD1 . TYR A 1 568 ? 33.779 5.923 -16.139 1.00 20.29 ? 585 TYR A CD1 1 ATOM 4630 C CD2 . TYR A 1 568 ? 34.445 3.767 -15.354 1.00 20.19 ? 585 TYR A CD2 1 ATOM 4631 C CE1 . TYR A 1 568 ? 33.892 5.486 -17.451 1.00 19.76 ? 585 TYR A CE1 1 ATOM 4632 C CE2 . TYR A 1 568 ? 34.555 3.324 -16.659 1.00 19.99 ? 585 TYR A CE2 1 ATOM 4633 C CZ . TYR A 1 568 ? 34.280 4.184 -17.706 1.00 20.02 ? 585 TYR A CZ 1 ATOM 4634 O OH . TYR A 1 568 ? 34.387 3.732 -19.004 1.00 19.68 ? 585 TYR A OH 1 ATOM 4635 N N . PHE A 1 569 ? 34.262 8.657 -13.578 1.00 21.47 ? 586 PHE A N 1 ATOM 4636 C CA . PHE A 1 569 ? 34.154 9.914 -14.326 1.00 21.98 ? 586 PHE A CA 1 ATOM 4637 C C . PHE A 1 569 ? 34.888 11.105 -13.716 1.00 22.65 ? 586 PHE A C 1 ATOM 4638 O O . PHE A 1 569 ? 34.772 12.216 -14.233 1.00 23.05 ? 586 PHE A O 1 ATOM 4639 C CB . PHE A 1 569 ? 32.678 10.269 -14.536 1.00 21.76 ? 586 PHE A CB 1 ATOM 4640 C CG . PHE A 1 569 ? 31.967 9.318 -15.446 1.00 21.01 ? 586 PHE A CG 1 ATOM 4641 C CD1 . PHE A 1 569 ? 32.189 9.358 -16.817 1.00 20.71 ? 586 PHE A CD1 1 ATOM 4642 C CD2 . PHE A 1 569 ? 31.086 8.373 -14.940 1.00 20.35 ? 586 PHE A CD2 1 ATOM 4643 C CE1 . PHE A 1 569 ? 31.543 8.469 -17.665 1.00 20.88 ? 586 PHE A CE1 1 ATOM 4644 C CE2 . PHE A 1 569 ? 30.436 7.488 -15.781 1.00 20.37 ? 586 PHE A CE2 1 ATOM 4645 C CZ . PHE A 1 569 ? 30.662 7.537 -17.147 1.00 20.37 ? 586 PHE A CZ 1 ATOM 4646 N N . GLU A 1 570 ? 35.659 10.882 -12.652 1.00 23.81 ? 587 GLU A N 1 ATOM 4647 C CA . GLU A 1 570 ? 36.354 11.969 -11.969 1.00 26.54 ? 587 GLU A CA 1 ATOM 4648 C C . GLU A 1 570 ? 37.264 12.778 -12.921 1.00 25.77 ? 587 GLU A C 1 ATOM 4649 O O . GLU A 1 570 ? 37.180 14.007 -12.928 1.00 26.39 ? 587 GLU A O 1 ATOM 4650 C CB . GLU A 1 570 ? 37.088 11.437 -10.720 1.00 28.06 ? 587 GLU A CB 1 ATOM 4651 C CG . GLU A 1 570 ? 37.861 12.462 -9.903 1.00 30.32 ? 587 GLU A CG 1 ATOM 4652 C CD . GLU A 1 570 ? 37.028 13.621 -9.405 1.00 32.74 ? 587 GLU A CD 1 ATOM 4653 O OE1 . GLU A 1 570 ? 35.789 13.518 -9.299 1.00 36.08 ? 587 GLU A OE1 1 ATOM 4654 O OE2 . GLU A 1 570 ? 37.622 14.672 -9.107 1.00 36.50 ? 587 GLU A OE2 1 ATOM 4655 N N . PRO A 1 571 ? 38.069 12.104 -13.770 1.00 26.19 ? 588 PRO A N 1 ATOM 4656 C CA . PRO A 1 571 ? 38.856 12.858 -14.769 1.00 27.08 ? 588 PRO A CA 1 ATOM 4657 C C . PRO A 1 571 ? 38.009 13.744 -15.704 1.00 28.02 ? 588 PRO A C 1 ATOM 4658 O O . PRO A 1 571 ? 38.422 14.863 -16.040 1.00 27.22 ? 588 PRO A O 1 ATOM 4659 C CB . PRO A 1 571 ? 39.571 11.763 -15.563 1.00 27.25 ? 588 PRO A CB 1 ATOM 4660 C CG . PRO A 1 571 ? 39.594 10.583 -14.656 1.00 27.96 ? 588 PRO A CG 1 ATOM 4661 C CD . PRO A 1 571 ? 38.318 10.654 -13.875 1.00 27.01 ? 588 PRO A CD 1 ATOM 4662 N N . LEU A 1 572 ? 36.831 13.258 -16.101 1.00 26.31 ? 589 LEU A N 1 ATOM 4663 C CA . LEU A 1 572 ? 35.913 14.054 -16.909 1.00 26.23 ? 589 LEU A CA 1 ATOM 4664 C C . LEU A 1 572 ? 35.348 15.249 -16.149 1.00 26.49 ? 589 LEU A C 1 ATOM 4665 O O . LEU A 1 572 ? 35.230 16.335 -16.716 1.00 26.43 ? 589 LEU A O 1 ATOM 4666 C CB . LEU A 1 572 ? 34.760 13.188 -17.439 1.00 26.12 ? 589 LEU A CB 1 ATOM 4667 C CG . LEU A 1 572 ? 33.785 13.890 -18.383 1.00 26.11 ? 589 LEU A CG 1 ATOM 4668 C CD1 . LEU A 1 572 ? 34.503 14.319 -19.655 1.00 26.45 ? 589 LEU A CD1 1 ATOM 4669 C CD2 . LEU A 1 572 ? 32.608 12.972 -18.688 1.00 26.18 ? 589 LEU A CD2 1 ATOM 4670 N N . ARG A 1 573 ? 34.970 15.044 -14.888 1.00 27.02 ? 590 ARG A N 1 ATOM 4671 C CA . ARG A 1 573 ? 34.422 16.121 -14.052 1.00 28.17 ? 590 ARG A CA 1 ATOM 4672 C C . ARG A 1 573 ? 35.386 17.306 -13.961 1.00 28.31 ? 590 ARG A C 1 ATOM 4673 O O . ARG A 1 573 ? 34.973 18.459 -14.106 1.00 27.74 ? 590 ARG A O 1 ATOM 4674 C CB . ARG A 1 573 ? 34.112 15.614 -12.638 1.00 29.88 ? 590 ARG A CB 1 ATOM 4675 C CG . ARG A 1 573 ? 33.387 16.628 -11.752 1.00 32.15 ? 590 ARG A CG 1 ATOM 4676 C CD . ARG A 1 573 ? 33.399 16.237 -10.283 1.00 34.75 ? 590 ARG A CD 1 ATOM 4677 N NE . ARG A 1 573 ? 34.756 16.199 -9.732 1.00 37.92 ? 590 ARG A NE 1 ATOM 4678 C CZ . ARG A 1 573 ? 35.479 17.265 -9.369 1.00 40.44 ? 590 ARG A CZ 1 ATOM 4679 N NH1 . ARG A 1 573 ? 34.999 18.503 -9.460 1.00 41.80 ? 590 ARG A NH1 1 ATOM 4680 N NH2 . ARG A 1 573 ? 36.708 17.089 -8.895 1.00 42.18 ? 590 ARG A NH2 1 ATOM 4681 N N . VAL A 1 574 ? 36.658 16.998 -13.724 1.00 28.89 ? 591 VAL A N 1 ATOM 4682 C CA . VAL A 1 574 ? 37.711 18.008 -13.587 1.00 30.75 ? 591 VAL A CA 1 ATOM 4683 C C . VAL A 1 574 ? 37.849 18.810 -14.891 1.00 30.22 ? 591 VAL A C 1 ATOM 4684 O O . VAL A 1 574 ? 37.732 20.041 -14.894 1.00 30.12 ? 591 VAL A O 1 ATOM 4685 C CB . VAL A 1 574 ? 39.062 17.357 -13.189 1.00 32.11 ? 591 VAL A CB 1 ATOM 4686 C CG1 . VAL A 1 574 ? 40.209 18.369 -13.240 1.00 32.90 ? 591 VAL A CG1 1 ATOM 4687 C CG2 . VAL A 1 574 ? 38.976 16.743 -11.795 1.00 31.99 ? 591 VAL A CG2 1 ATOM 4688 N N . TRP A 1 575 ? 38.066 18.106 -15.997 1.00 30.74 ? 592 TRP A N 1 ATOM 4689 C CA . TRP A 1 575 ? 38.179 18.752 -17.306 1.00 30.51 ? 592 TRP A CA 1 ATOM 4690 C C . TRP A 1 575 ? 36.952 19.594 -17.657 1.00 30.19 ? 592 TRP A C 1 ATOM 4691 O O . TRP A 1 575 ? 37.073 20.735 -18.098 1.00 29.41 ? 592 TRP A O 1 ATOM 4692 C CB . TRP A 1 575 ? 38.415 17.715 -18.405 1.00 31.79 ? 592 TRP A CB 1 ATOM 4693 C CG . TRP A 1 575 ? 38.551 18.347 -19.756 1.00 32.70 ? 592 TRP A CG 1 ATOM 4694 C CD1 . TRP A 1 575 ? 39.702 18.799 -20.332 1.00 33.73 ? 592 TRP A CD1 1 ATOM 4695 C CD2 . TRP A 1 575 ? 37.496 18.633 -20.684 1.00 33.20 ? 592 TRP A CD2 1 ATOM 4696 N NE1 . TRP A 1 575 ? 39.433 19.339 -21.564 1.00 34.12 ? 592 TRP A NE1 1 ATOM 4697 C CE2 . TRP A 1 575 ? 38.088 19.247 -21.809 1.00 33.97 ? 592 TRP A CE2 1 ATOM 4698 C CE3 . TRP A 1 575 ? 36.110 18.419 -20.680 1.00 33.53 ? 592 TRP A CE3 1 ATOM 4699 C CZ2 . TRP A 1 575 ? 37.342 19.655 -22.921 1.00 34.83 ? 592 TRP A CZ2 1 ATOM 4700 C CZ3 . TRP A 1 575 ? 35.369 18.822 -21.787 1.00 34.10 ? 592 TRP A CZ3 1 ATOM 4701 C CH2 . TRP A 1 575 ? 35.986 19.437 -22.888 1.00 34.56 ? 592 TRP A CH2 1 ATOM 4702 N N . LEU A 1 576 ? 35.771 19.024 -17.451 1.00 29.43 ? 593 LEU A N 1 ATOM 4703 C CA . LEU A 1 576 ? 34.522 19.654 -17.863 1.00 28.45 ? 593 LEU A CA 1 ATOM 4704 C C . LEU A 1 576 ? 34.190 20.923 -17.070 1.00 27.97 ? 593 LEU A C 1 ATOM 4705 O O . LEU A 1 576 ? 33.769 21.929 -17.651 1.00 26.57 ? 593 LEU A O 1 ATOM 4706 C CB . LEU A 1 576 ? 33.390 18.623 -17.748 1.00 29.54 ? 593 LEU A CB 1 ATOM 4707 C CG . LEU A 1 576 ? 32.049 18.867 -18.403 1.00 29.63 ? 593 LEU A CG 1 ATOM 4708 C CD1 . LEU A 1 576 ? 32.190 19.179 -19.890 1.00 29.27 ? 593 LEU A CD1 1 ATOM 4709 C CD2 . LEU A 1 576 ? 31.200 17.616 -18.200 1.00 29.68 ? 593 LEU A CD2 1 ATOM 4710 N N . GLU A 1 577 ? 34.381 20.878 -15.752 1.00 28.70 ? 594 GLU A N 1 ATOM 4711 C CA . GLU A 1 577 ? 34.242 22.074 -14.910 1.00 29.36 ? 594 GLU A CA 1 ATOM 4712 C C . GLU A 1 577 ? 35.154 23.213 -15.391 1.00 29.68 ? 594 GLU A C 1 ATOM 4713 O O . GLU A 1 577 ? 34.715 24.358 -15.495 1.00 30.11 ? 594 GLU A O 1 ATOM 4714 C CB . GLU A 1 577 ? 34.524 21.755 -13.436 1.00 31.34 ? 594 GLU A CB 1 ATOM 4715 C CG . GLU A 1 577 ? 33.382 21.026 -12.740 1.00 33.39 ? 594 GLU A CG 1 ATOM 4716 C CD . GLU A 1 577 ? 33.648 20.741 -11.274 1.00 36.09 ? 594 GLU A CD 1 ATOM 4717 O OE1 . GLU A 1 577 ? 34.506 21.412 -10.657 1.00 38.80 ? 594 GLU A OE1 1 ATOM 4718 O OE2 . GLU A 1 577 ? 32.999 19.827 -10.724 1.00 36.05 ? 594 GLU A OE2 1 ATOM 4719 N N . ALA A 1 578 ? 36.402 22.885 -15.709 1.00 29.58 ? 595 ALA A N 1 ATOM 4720 C CA . ALA A 1 578 ? 37.362 23.880 -16.218 1.00 30.56 ? 595 ALA A CA 1 ATOM 4721 C C . ALA A 1 578 ? 36.947 24.396 -17.598 1.00 31.41 ? 595 ALA A C 1 ATOM 4722 O O . ALA A 1 578 ? 36.992 25.603 -17.857 1.00 30.74 ? 595 ALA A O 1 ATOM 4723 C CB . ALA A 1 578 ? 38.759 23.291 -16.271 1.00 30.20 ? 595 ALA A CB 1 ATOM 4724 N N . GLU A 1 579 ? 36.508 23.487 -18.468 1.00 31.05 ? 596 GLU A N 1 ATOM 4725 C CA . GLU A 1 579 ? 36.080 23.866 -19.812 1.00 30.70 ? 596 GLU A CA 1 ATOM 4726 C C . GLU A 1 579 ? 34.852 24.768 -19.812 1.00 29.62 ? 596 GLU A C 1 ATOM 4727 O O . GLU A 1 579 ? 34.784 25.716 -20.602 1.00 28.35 ? 596 GLU A O 1 ATOM 4728 C CB . GLU A 1 579 ? 35.804 22.634 -20.677 1.00 32.44 ? 596 GLU A CB 1 ATOM 4729 C CG . GLU A 1 579 ? 35.733 22.931 -22.168 1.00 34.70 ? 596 GLU A CG 1 ATOM 4730 C CD . GLU A 1 579 ? 37.070 23.368 -22.756 1.00 36.39 ? 596 GLU A CD 1 ATOM 4731 O OE1 . GLU A 1 579 ? 38.132 23.142 -22.137 1.00 37.79 ? 596 GLU A OE1 1 ATOM 4732 O OE2 . GLU A 1 579 ? 37.057 23.945 -23.854 1.00 41.14 ? 596 GLU A OE2 1 ATOM 4733 N N . ASN A 1 580 ? 33.882 24.480 -18.944 1.00 27.96 ? 597 ASN A N 1 ATOM 4734 C CA . ASN A 1 580 ? 32.678 25.305 -18.873 1.00 27.33 ? 597 ASN A CA 1 ATOM 4735 C C . ASN A 1 580 ? 32.967 26.722 -18.365 1.00 28.71 ? 597 ASN A C 1 ATOM 4736 O O . ASN A 1 580 ? 32.415 27.691 -18.884 1.00 28.78 ? 597 ASN A O 1 ATOM 4737 C CB . ASN A 1 580 ? 31.594 24.633 -18.020 1.00 26.45 ? 597 ASN A CB 1 ATOM 4738 C CG . ASN A 1 580 ? 30.914 23.479 -18.742 1.00 24.97 ? 597 ASN A CG 1 ATOM 4739 O OD1 . ASN A 1 580 ? 30.853 23.453 -19.971 1.00 23.40 ? 597 ASN A OD1 1 ATOM 4740 N ND2 . ASN A 1 580 ? 30.391 22.523 -17.978 1.00 25.26 ? 597 ASN A ND2 1 ATOM 4741 N N . ILE A 1 581 ? 33.815 26.829 -17.349 1.00 30.61 ? 598 ILE A N 1 ATOM 4742 C CA . ILE A 1 581 ? 34.240 28.136 -16.829 1.00 32.99 ? 598 ILE A CA 1 ATOM 4743 C C . ILE A 1 581 ? 35.011 28.913 -17.908 1.00 34.26 ? 598 ILE A C 1 ATOM 4744 O O . ILE A 1 581 ? 34.737 30.094 -18.142 1.00 35.22 ? 598 ILE A O 1 ATOM 4745 C CB . ILE A 1 581 ? 35.065 27.976 -15.525 1.00 34.06 ? 598 ILE A CB 1 ATOM 4746 C CG1 . ILE A 1 581 ? 34.126 27.627 -14.361 1.00 34.04 ? 598 ILE A CG1 1 ATOM 4747 C CG2 . ILE A 1 581 ? 35.862 29.245 -15.201 1.00 34.50 ? 598 ILE A CG2 1 ATOM 4748 C CD1 . ILE A 1 581 ? 34.815 27.051 -13.141 1.00 33.77 ? 598 ILE A CD1 1 ATOM 4749 N N . LYS A 1 582 ? 35.942 28.232 -18.573 1.00 35.50 ? 599 LYS A N 1 ATOM 4750 C CA . LYS A 1 582 ? 36.754 28.810 -19.656 1.00 37.16 ? 599 LYS A CA 1 ATOM 4751 C C . LYS A 1 582 ? 35.894 29.405 -20.767 1.00 36.94 ? 599 LYS A C 1 ATOM 4752 O O . LYS A 1 582 ? 36.153 30.518 -21.226 1.00 35.82 ? 599 LYS A O 1 ATOM 4753 C CB . LYS A 1 582 ? 37.688 27.731 -20.228 1.00 39.43 ? 599 LYS A CB 1 ATOM 4754 C CG . LYS A 1 582 ? 38.603 28.152 -21.370 1.00 41.61 ? 599 LYS A CG 1 ATOM 4755 C CD . LYS A 1 582 ? 39.340 26.947 -21.945 1.00 43.78 ? 599 LYS A CD 1 ATOM 4756 C CE . LYS A 1 582 ? 40.095 27.297 -23.220 1.00 47.25 ? 599 LYS A CE 1 ATOM 4757 N NZ . LYS A 1 582 ? 40.429 26.087 -24.028 1.00 49.44 ? 599 LYS A NZ 1 ATOM 4758 N N . ASN A 1 583 ? 34.870 28.661 -21.186 1.00 35.76 ? 600 ASN A N 1 ATOM 4759 C CA . ASN A 1 583 ? 33.964 29.093 -22.253 1.00 35.07 ? 600 ASN A CA 1 ATOM 4760 C C . ASN A 1 583 ? 32.712 29.829 -21.765 1.00 33.90 ? 600 ASN A C 1 ATOM 4761 O O . ASN A 1 583 ? 31.814 30.110 -22.557 1.00 33.89 ? 600 ASN A O 1 ATOM 4762 C CB . ASN A 1 583 ? 33.574 27.886 -23.110 1.00 36.46 ? 600 ASN A CB 1 ATOM 4763 C CG . ASN A 1 583 ? 34.730 27.369 -23.936 1.00 38.12 ? 600 ASN A CG 1 ATOM 4764 O OD1 . ASN A 1 583 ? 35.030 27.912 -25.000 1.00 41.24 ? 600 ASN A OD1 1 ATOM 4765 N ND2 . ASN A 1 583 ? 35.378 26.306 -23.465 1.00 39.33 ? 600 ASN A ND2 1 ATOM 4766 N N . ASN A 1 584 ? 32.657 30.149 -20.475 1.00 32.57 ? 601 ASN A N 1 ATOM 4767 C CA . ASN A 1 584 ? 31.532 30.856 -19.882 1.00 34.06 ? 601 ASN A CA 1 ATOM 4768 C C . ASN A 1 584 ? 30.174 30.168 -20.151 1.00 31.93 ? 601 ASN A C 1 ATOM 4769 O O . ASN A 1 584 ? 29.176 30.816 -20.485 1.00 29.51 ? 601 ASN A O 1 ATOM 4770 C CB . ASN A 1 584 ? 31.543 32.317 -20.357 1.00 38.31 ? 601 ASN A CB 1 ATOM 4771 C CG . ASN A 1 584 ? 31.129 33.274 -19.270 1.00 42.68 ? 601 ASN A CG 1 ATOM 4772 O OD1 . ASN A 1 584 ? 31.928 33.604 -18.392 1.00 49.00 ? 601 ASN A OD1 1 ATOM 4773 N ND2 . ASN A 1 584 ? 29.884 33.724 -19.316 1.00 44.50 ? 601 ASN A ND2 1 ATOM 4774 N N . VAL A 1 585 ? 30.162 28.845 -19.989 1.00 30.02 ? 602 VAL A N 1 ATOM 4775 C CA . VAL A 1 585 ? 29.013 28.012 -20.351 1.00 28.64 ? 602 VAL A CA 1 ATOM 4776 C C . VAL A 1 585 ? 27.940 28.148 -19.283 1.00 27.62 ? 602 VAL A C 1 ATOM 4777 O O . VAL A 1 585 ? 28.209 27.939 -18.107 1.00 27.96 ? 602 VAL A O 1 ATOM 4778 C CB . VAL A 1 585 ? 29.425 26.522 -20.508 1.00 27.87 ? 602 VAL A CB 1 ATOM 4779 C CG1 . VAL A 1 585 ? 28.209 25.623 -20.762 1.00 27.64 ? 602 VAL A CG1 1 ATOM 4780 C CG2 . VAL A 1 585 ? 30.441 26.375 -21.632 1.00 27.45 ? 602 VAL A CG2 1 ATOM 4781 N N . HIS A 1 586 ? 26.726 28.485 -19.699 1.00 27.67 ? 603 HIS A N 1 ATOM 4782 C CA . HIS A 1 586 ? 25.611 28.628 -18.774 1.00 28.48 ? 603 HIS A CA 1 ATOM 4783 C C . HIS A 1 586 ? 25.186 27.253 -18.229 1.00 27.49 ? 603 HIS A C 1 ATOM 4784 O O . HIS A 1 586 ? 25.106 26.277 -18.982 1.00 26.77 ? 603 HIS A O 1 ATOM 4785 C CB . HIS A 1 586 ? 24.432 29.324 -19.450 1.00 29.59 ? 603 HIS A CB 1 ATOM 4786 C CG . HIS A 1 586 ? 23.289 29.591 -18.523 1.00 31.92 ? 603 HIS A CG 1 ATOM 4787 N ND1 . HIS A 1 586 ? 23.306 30.610 -17.594 1.00 33.52 ? 603 HIS A ND1 1 ATOM 4788 C CD2 . HIS A 1 586 ? 22.105 28.957 -18.361 1.00 33.92 ? 603 HIS A CD2 1 ATOM 4789 C CE1 . HIS A 1 586 ? 22.176 30.602 -16.911 1.00 34.11 ? 603 HIS A CE1 1 ATOM 4790 N NE2 . HIS A 1 586 ? 21.432 29.604 -17.352 1.00 34.77 ? 603 HIS A NE2 1 ATOM 4791 N N . ILE A 1 587 ? 24.929 27.199 -16.923 1.00 26.45 ? 604 ILE A N 1 ATOM 4792 C CA . ILE A 1 587 ? 24.583 25.964 -16.214 1.00 25.93 ? 604 ILE A CA 1 ATOM 4793 C C . ILE A 1 587 ? 23.195 26.144 -15.621 1.00 25.44 ? 604 ILE A C 1 ATOM 4794 O O . ILE A 1 587 ? 22.897 27.192 -15.068 1.00 25.76 ? 604 ILE A O 1 ATOM 4795 C CB . ILE A 1 587 ? 25.581 25.660 -15.072 1.00 25.90 ? 604 ILE A CB 1 ATOM 4796 C CG1 . ILE A 1 587 ? 27.022 25.594 -15.599 1.00 26.46 ? 604 ILE A CG1 1 ATOM 4797 C CG2 . ILE A 1 587 ? 25.203 24.373 -14.345 1.00 25.35 ? 604 ILE A CG2 1 ATOM 4798 C CD1 . ILE A 1 587 ? 27.288 24.519 -16.637 1.00 26.71 ? 604 ILE A CD1 1 ATOM 4799 N N . GLY A 1 588 ? 22.357 25.116 -15.736 1.00 23.94 ? 605 GLY A N 1 ATOM 4800 C CA . GLY A 1 588 ? 20.995 25.165 -15.246 1.00 24.15 ? 605 GLY A CA 1 ATOM 4801 C C . GLY A 1 588 ? 20.064 25.658 -16.323 1.00 23.69 ? 605 GLY A C 1 ATOM 4802 O O . GLY A 1 588 ? 20.497 26.048 -17.412 1.00 24.73 ? 605 GLY A O 1 ATOM 4803 N N . TRP A 1 589 ? 18.774 25.652 -16.027 1.00 23.08 ? 606 TRP A N 1 ATOM 4804 C CA . TRP A 1 589 ? 17.780 26.017 -17.023 1.00 23.56 ? 606 TRP A CA 1 ATOM 4805 C C . TRP A 1 589 ? 16.542 26.657 -16.419 1.00 24.97 ? 606 TRP A C 1 ATOM 4806 O O . TRP A 1 589 ? 16.204 26.411 -15.271 1.00 25.39 ? 606 TRP A O 1 ATOM 4807 C CB . TRP A 1 589 ? 17.380 24.788 -17.856 1.00 22.69 ? 606 TRP A CB 1 ATOM 4808 C CG . TRP A 1 589 ? 16.993 23.613 -17.029 1.00 21.33 ? 606 TRP A CG 1 ATOM 4809 C CD1 . TRP A 1 589 ? 15.757 23.332 -16.549 1.00 21.36 ? 606 TRP A CD1 1 ATOM 4810 C CD2 . TRP A 1 589 ? 17.850 22.561 -16.572 1.00 20.72 ? 606 TRP A CD2 1 ATOM 4811 N NE1 . TRP A 1 589 ? 15.781 22.170 -15.827 1.00 20.69 ? 606 TRP A NE1 1 ATOM 4812 C CE2 . TRP A 1 589 ? 17.056 21.680 -15.812 1.00 20.53 ? 606 TRP A CE2 1 ATOM 4813 C CE3 . TRP A 1 589 ? 19.210 22.275 -16.732 1.00 20.73 ? 606 TRP A CE3 1 ATOM 4814 C CZ2 . TRP A 1 589 ? 17.567 20.525 -15.226 1.00 20.46 ? 606 TRP A CZ2 1 ATOM 4815 C CZ3 . TRP A 1 589 ? 19.723 21.119 -16.148 1.00 20.57 ? 606 TRP A CZ3 1 ATOM 4816 C CH2 . TRP A 1 589 ? 18.898 20.264 -15.397 1.00 21.26 ? 606 TRP A CH2 1 ATOM 4817 N N . THR A 1 590 ? 15.885 27.488 -17.219 1.00 27.07 ? 607 THR A N 1 ATOM 4818 C CA . THR A 1 590 ? 14.572 28.043 -16.883 1.00 27.58 ? 607 THR A CA 1 ATOM 4819 C C . THR A 1 590 ? 13.512 26.972 -17.085 1.00 27.27 ? 607 THR A C 1 ATOM 4820 O O . THR A 1 590 ? 13.747 25.975 -17.784 1.00 26.73 ? 607 THR A O 1 ATOM 4821 C CB . THR A 1 590 ? 14.231 29.240 -17.783 1.00 29.36 ? 607 THR A CB 1 ATOM 4822 O OG1 . THR A 1 590 ? 14.341 28.852 -19.161 1.00 29.99 ? 607 THR A OG1 1 ATOM 4823 C CG2 . THR A 1 590 ? 15.182 30.409 -17.510 1.00 30.50 ? 607 THR A CG2 1 ATOM 4824 N N . THR A 1 591 ? 12.347 27.181 -16.476 1.00 25.58 ? 608 THR A N 1 ATOM 4825 C CA . THR A 1 591 ? 11.215 26.272 -16.636 1.00 25.56 ? 608 THR A CA 1 ATOM 4826 C C . THR A 1 591 ? 10.746 26.289 -18.088 1.00 23.95 ? 608 THR A C 1 ATOM 4827 O O . THR A 1 591 ? 10.730 27.339 -18.721 1.00 23.60 ? 608 THR A O 1 ATOM 4828 C CB . THR A 1 591 ? 10.067 26.653 -15.679 1.00 27.19 ? 608 THR A CB 1 ATOM 4829 O OG1 . THR A 1 591 ? 10.569 26.648 -14.335 1.00 29.12 ? 608 THR A OG1 1 ATOM 4830 C CG2 . THR A 1 591 ? 8.933 25.662 -15.756 1.00 28.17 ? 608 THR A CG2 1 ATOM 4831 N N . SER A 1 592 ? 10.379 25.120 -18.602 1.00 22.28 ? 609 SER A N 1 ATOM 4832 C CA . SER A 1 592 ? 9.968 24.949 -20.001 1.00 21.06 ? 609 SER A CA 1 ATOM 4833 C C . SER A 1 592 ? 8.683 25.693 -20.342 1.00 21.60 ? 609 SER A C 1 ATOM 4834 O O . SER A 1 592 ? 7.764 25.744 -19.529 1.00 23.01 ? 609 SER A O 1 ATOM 4835 C CB . SER A 1 592 ? 9.744 23.455 -20.300 1.00 19.98 ? 609 SER A CB 1 ATOM 4836 O OG . SER A 1 592 ? 9.289 23.244 -21.627 1.00 18.08 ? 609 SER A OG 1 ATOM 4837 N N . ASN A 1 593 ? 8.620 26.224 -21.559 1.00 22.14 ? 610 ASN A N 1 ATOM 4838 C CA . ASN A 1 593 ? 7.396 26.829 -22.101 1.00 22.84 ? 610 ASN A CA 1 ATOM 4839 C C . ASN A 1 593 ? 6.595 25.866 -22.998 1.00 22.28 ? 610 ASN A C 1 ATOM 4840 O O . ASN A 1 593 ? 5.683 26.298 -23.694 1.00 22.19 ? 610 ASN A O 1 ATOM 4841 C CB . ASN A 1 593 ? 7.721 28.151 -22.837 1.00 24.18 ? 610 ASN A CB 1 ATOM 4842 C CG . ASN A 1 593 ? 8.619 27.976 -24.069 1.00 25.26 ? 610 ASN A CG 1 ATOM 4843 O OD1 . ASN A 1 593 ? 8.632 26.935 -24.727 1.00 25.94 ? 610 ASN A OD1 1 ATOM 4844 N ND2 . ASN A 1 593 ? 9.365 29.020 -24.392 1.00 25.88 ? 610 ASN A ND2 1 ATOM 4845 N N . LYS A 1 594 ? 6.919 24.565 -22.967 1.00 20.88 ? 611 LYS A N 1 ATOM 4846 C CA . LYS A 1 594 ? 6.402 23.623 -23.967 1.00 20.57 ? 611 LYS A CA 1 ATOM 4847 C C . LYS A 1 594 ? 5.207 22.762 -23.555 1.00 21.27 ? 611 LYS A C 1 ATOM 4848 O O . LYS A 1 594 ? 4.828 21.873 -24.321 1.00 21.21 ? 611 LYS A O 1 ATOM 4849 C CB . LYS A 1 594 ? 7.546 22.725 -24.479 1.00 20.16 ? 611 LYS A CB 1 ATOM 4850 C CG . LYS A 1 594 ? 8.664 23.476 -25.180 1.00 20.01 ? 611 LYS A CG 1 ATOM 4851 C CD . LYS A 1 594 ? 8.199 24.116 -26.482 1.00 20.00 ? 611 LYS A CD 1 ATOM 4852 C CE . LYS A 1 594 ? 9.366 24.616 -27.322 1.00 20.37 ? 611 LYS A CE 1 ATOM 4853 N NZ . LYS A 1 594 ? 10.236 25.584 -26.602 1.00 19.84 ? 611 LYS A NZ 1 ATOM 4854 N N . CYS A 1 595 ? 4.612 22.975 -22.379 1.00 21.35 ? 612 CYS A N 1 ATOM 4855 C CA . CYS A 1 595 ? 3.390 22.220 -22.023 1.00 22.77 ? 612 CYS A CA 1 ATOM 4856 C C . CYS A 1 595 ? 2.314 23.153 -21.476 1.00 23.06 ? 612 CYS A C 1 ATOM 4857 O O . CYS A 1 595 ? 2.493 23.773 -20.437 1.00 23.40 ? 612 CYS A O 1 ATOM 4858 C CB . CYS A 1 595 ? 3.664 21.063 -21.042 1.00 23.67 ? 612 CYS A CB 1 ATOM 4859 S SG . CYS A 1 595 ? 2.406 19.735 -21.036 1.00 24.71 ? 612 CYS A SG 1 ATOM 4860 N N . VAL A 1 596 ? 1.212 23.251 -22.212 1.00 23.38 ? 613 VAL A N 1 ATOM 4861 C CA . VAL A 1 596 ? 0.070 24.084 -21.844 1.00 24.02 ? 613 VAL A CA 1 ATOM 4862 C C . VAL A 1 596 ? -0.861 23.278 -20.954 1.00 24.99 ? 613 VAL A C 1 ATOM 4863 O O . VAL A 1 596 ? -1.333 22.211 -21.349 1.00 23.91 ? 613 VAL A O 1 ATOM 4864 C CB . VAL A 1 596 ? -0.701 24.547 -23.102 1.00 24.35 ? 613 VAL A CB 1 ATOM 4865 C CG1 . VAL A 1 596 ? -1.989 25.280 -22.727 1.00 25.07 ? 613 VAL A CG1 1 ATOM 4866 C CG2 . VAL A 1 596 ? 0.181 25.436 -23.958 1.00 23.58 ? 613 VAL A CG2 1 ATOM 4867 N N . SER A 1 597 ? -1.107 23.771 -19.746 1.00 27.73 ? 614 SER A N 1 ATOM 4868 C CA . SER A 1 597 ? -2.127 23.180 -18.880 1.00 31.15 ? 614 SER A CA 1 ATOM 4869 C C . SER A 1 597 ? -3.514 23.577 -19.354 1.00 32.70 ? 614 SER A C 1 ATOM 4870 O O . SER A 1 597 ? -4.478 22.867 -19.086 1.00 40.27 ? 614 SER A O 1 ATOM 4871 C CB . SER A 1 597 ? -1.927 23.618 -17.436 1.00 32.10 ? 614 SER A CB 1 ATOM 4872 O OG . SER A 1 597 ? -0.671 23.180 -16.964 1.00 34.93 ? 614 SER A OG 1 HETATM 4873 C C1 . MLT B 2 . ? 15.878 0.882 -22.471 1.00 26.00 ? 1615 MLT A C1 1 HETATM 4874 O O1 . MLT B 2 . ? 15.227 1.895 -22.117 1.00 21.91 ? 1615 MLT A O1 1 HETATM 4875 O O2 . MLT B 2 . ? 15.837 0.496 -23.656 1.00 26.20 ? 1615 MLT A O2 1 HETATM 4876 C C2 . MLT B 2 . ? 16.713 0.110 -21.467 1.00 27.04 ? 1615 MLT A C2 1 HETATM 4877 O O3 . MLT B 2 . ? 17.796 0.935 -21.010 1.00 30.65 ? 1615 MLT A O3 1 HETATM 4878 C C3 . MLT B 2 . ? 17.368 -1.150 -22.022 1.00 27.55 ? 1615 MLT A C3 1 HETATM 4879 C C4 . MLT B 2 . ? 16.400 -2.210 -22.498 1.00 30.53 ? 1615 MLT A C4 1 HETATM 4880 O O4 . MLT B 2 . ? 16.866 -3.231 -23.098 1.00 35.88 ? 1615 MLT A O4 1 HETATM 4881 O O5 . MLT B 2 . ? 15.172 -2.059 -22.280 1.00 29.21 ? 1615 MLT A O5 1 HETATM 4882 ZN ZN . ZN C 3 . ? 17.702 -5.696 -19.577 1.00 20.97 ? 1616 ZN A ZN 1 HETATM 4883 C C1 . NAG D 4 . ? 35.895 -22.412 -13.712 1.00 43.86 ? 1621 NAG A C1 1 HETATM 4884 C C2 . NAG D 4 . ? 36.755 -22.728 -12.494 1.00 47.45 ? 1621 NAG A C2 1 HETATM 4885 C C3 . NAG D 4 . ? 36.407 -24.055 -11.812 1.00 49.15 ? 1621 NAG A C3 1 HETATM 4886 C C4 . NAG D 4 . ? 34.906 -24.348 -11.818 1.00 49.88 ? 1621 NAG A C4 1 HETATM 4887 C C5 . NAG D 4 . ? 34.327 -24.105 -13.210 1.00 50.43 ? 1621 NAG A C5 1 HETATM 4888 C C6 . NAG D 4 . ? 32.831 -24.395 -13.316 1.00 49.86 ? 1621 NAG A C6 1 HETATM 4889 C C7 . NAG D 4 . ? 38.961 -21.617 -12.661 1.00 50.33 ? 1621 NAG A C7 1 HETATM 4890 C C8 . NAG D 4 . ? 40.355 -21.685 -13.221 1.00 51.06 ? 1621 NAG A C8 1 HETATM 4891 N N2 . NAG D 4 . ? 38.141 -22.645 -12.942 1.00 48.23 ? 1621 NAG A N2 1 HETATM 4892 O O3 . NAG D 4 . ? 36.827 -24.004 -10.467 1.00 51.39 ? 1621 NAG A O3 1 HETATM 4893 O O4 . NAG D 4 . ? 34.672 -25.678 -11.406 1.00 50.13 ? 1621 NAG A O4 1 HETATM 4894 O O5 . NAG D 4 . ? 34.542 -22.745 -13.514 1.00 46.69 ? 1621 NAG A O5 1 HETATM 4895 O O6 . NAG D 4 . ? 32.122 -23.540 -12.448 1.00 51.99 ? 1621 NAG A O6 1 HETATM 4896 O O7 . NAG D 4 . ? 38.653 -20.639 -11.973 1.00 50.98 ? 1621 NAG A O7 1 HETATM 4897 C C1 . NAG E 4 . ? 1.867 -15.751 -36.825 1.00 50.21 ? 1622 NAG A C1 1 HETATM 4898 C C2 . NAG E 4 . ? 2.447 -16.867 -37.688 1.00 53.95 ? 1622 NAG A C2 1 HETATM 4899 C C3 . NAG E 4 . ? 1.363 -17.389 -38.639 1.00 57.15 ? 1622 NAG A C3 1 HETATM 4900 C C4 . NAG E 4 . ? 0.162 -17.888 -37.826 1.00 57.82 ? 1622 NAG A C4 1 HETATM 4901 C C5 . NAG E 4 . ? -0.250 -16.875 -36.748 1.00 55.10 ? 1622 NAG A C5 1 HETATM 4902 C C6 . NAG E 4 . ? -1.181 -17.498 -35.715 1.00 54.31 ? 1622 NAG A C6 1 HETATM 4903 C C7 . NAG E 4 . ? 4.887 -16.923 -38.013 1.00 53.08 ? 1622 NAG A C7 1 HETATM 4904 C C8 . NAG E 4 . ? 6.044 -16.441 -38.839 1.00 53.16 ? 1622 NAG A C8 1 HETATM 4905 N N2 . NAG E 4 . ? 3.673 -16.486 -38.379 1.00 53.50 ? 1622 NAG A N2 1 HETATM 4906 O O3 . NAG E 4 . ? 1.880 -18.441 -39.426 1.00 59.19 ? 1622 NAG A O3 1 HETATM 4907 O O4 . NAG E 4 . ? -0.938 -18.169 -38.673 1.00 58.67 ? 1622 NAG A O4 1 HETATM 4908 O O5 . NAG E 4 . ? 0.865 -16.371 -36.036 1.00 51.57 ? 1622 NAG A O5 1 HETATM 4909 O O6 . NAG E 4 . ? -1.718 -16.462 -34.927 1.00 49.20 ? 1622 NAG A O6 1 HETATM 4910 O O7 . NAG E 4 . ? 5.107 -17.674 -37.062 1.00 51.19 ? 1622 NAG A O7 1 HETATM 4911 C C . TRS F 5 . ? 12.674 -10.816 -4.439 1.00 42.36 ? 7002 TRS A C 1 HETATM 4912 C C1 . TRS F 5 . ? 13.743 -10.004 -5.179 1.00 41.49 ? 7002 TRS A C1 1 HETATM 4913 C C2 . TRS F 5 . ? 12.336 -10.522 -2.987 1.00 43.71 ? 7002 TRS A C2 1 HETATM 4914 C C3 . TRS F 5 . ? 12.067 -12.046 -5.096 1.00 43.03 ? 7002 TRS A C3 1 HETATM 4915 N N . TRS F 5 . ? 11.514 -9.945 -4.934 1.00 40.35 ? 7002 TRS A N 1 HETATM 4916 O O1 . TRS F 5 . ? 13.290 -8.847 -5.898 1.00 39.36 ? 7002 TRS A O1 1 HETATM 4917 O O2 . TRS F 5 . ? 13.122 -11.401 -2.208 1.00 45.96 ? 7002 TRS A O2 1 HETATM 4918 O O3 . TRS F 5 . ? 11.969 -11.935 -6.515 1.00 38.92 ? 7002 TRS A O3 1 HETATM 4919 O O . HOH G 6 . ? 6.893 -33.217 14.956 1.00 39.24 ? 2001 HOH A O 1 HETATM 4920 O O . HOH G 6 . ? 9.157 -26.977 12.780 1.00 43.80 ? 2002 HOH A O 1 HETATM 4921 O O . HOH G 6 . ? 12.258 -29.885 7.228 1.00 44.51 ? 2003 HOH A O 1 HETATM 4922 O O . HOH G 6 . ? 12.416 -28.191 12.049 1.00 46.97 ? 2004 HOH A O 1 HETATM 4923 O O . HOH G 6 . ? 13.596 -27.319 7.473 1.00 41.63 ? 2005 HOH A O 1 HETATM 4924 O O . HOH G 6 . ? 10.802 -33.083 3.160 1.00 39.51 ? 2006 HOH A O 1 HETATM 4925 O O . HOH G 6 . ? 0.043 -34.792 3.285 1.00 46.11 ? 2007 HOH A O 1 HETATM 4926 O O . HOH G 6 . ? 11.604 -27.422 -0.523 1.00 29.24 ? 2008 HOH A O 1 HETATM 4927 O O . HOH G 6 . ? 13.608 -29.521 -1.300 1.00 44.76 ? 2009 HOH A O 1 HETATM 4928 O O . HOH G 6 . ? 14.026 -26.655 0.156 1.00 42.97 ? 2010 HOH A O 1 HETATM 4929 O O . HOH G 6 . ? 0.375 -27.438 -4.938 1.00 44.28 ? 2011 HOH A O 1 HETATM 4930 O O . HOH G 6 . ? 12.671 -26.722 -4.802 1.00 34.93 ? 2012 HOH A O 1 HETATM 4931 O O . HOH G 6 . ? 3.030 -29.178 -3.720 1.00 30.22 ? 2013 HOH A O 1 HETATM 4932 O O . HOH G 6 . ? 11.351 -25.658 -2.628 1.00 18.83 ? 2014 HOH A O 1 HETATM 4933 O O . HOH G 6 . ? 7.274 -31.570 -13.292 1.00 43.30 ? 2015 HOH A O 1 HETATM 4934 O O . HOH G 6 . ? 1.761 -27.451 -17.704 1.00 28.80 ? 2016 HOH A O 1 HETATM 4935 O O . HOH G 6 . ? 11.472 -27.703 -7.017 1.00 25.37 ? 2017 HOH A O 1 HETATM 4936 O O . HOH G 6 . ? 3.600 -28.339 -19.706 1.00 22.75 ? 2018 HOH A O 1 HETATM 4937 O O . HOH G 6 . ? 7.669 -29.002 -18.653 1.00 35.67 ? 2019 HOH A O 1 HETATM 4938 O O . HOH G 6 . ? 5.051 -35.531 -14.594 1.00 49.94 ? 2020 HOH A O 1 HETATM 4939 O O . HOH G 6 . ? 0.317 -25.277 -18.206 1.00 30.77 ? 2021 HOH A O 1 HETATM 4940 O O . HOH G 6 . ? -7.776 -23.148 -14.766 1.00 41.78 ? 2022 HOH A O 1 HETATM 4941 O O . HOH G 6 . ? -7.341 -26.755 -13.041 1.00 40.43 ? 2023 HOH A O 1 HETATM 4942 O O . HOH G 6 . ? 5.254 -31.035 -8.985 1.00 29.85 ? 2024 HOH A O 1 HETATM 4943 O O . HOH G 6 . ? 5.596 -13.707 -19.963 1.00 45.32 ? 2025 HOH A O 1 HETATM 4944 O O . HOH G 6 . ? 3.278 -20.704 -29.625 1.00 35.35 ? 2026 HOH A O 1 HETATM 4945 O O . HOH G 6 . ? 0.846 -19.315 -28.853 1.00 34.68 ? 2027 HOH A O 1 HETATM 4946 O O . HOH G 6 . ? 6.489 -8.912 -25.265 1.00 43.29 ? 2028 HOH A O 1 HETATM 4947 O O . HOH G 6 . ? 9.351 -28.075 -13.586 1.00 28.05 ? 2029 HOH A O 1 HETATM 4948 O O . HOH G 6 . ? 5.185 -30.592 -11.740 1.00 35.34 ? 2030 HOH A O 1 HETATM 4949 O O . HOH G 6 . ? 1.646 -31.322 -13.780 1.00 37.54 ? 2031 HOH A O 1 HETATM 4950 O O . HOH G 6 . ? -1.043 -29.659 -11.593 1.00 45.50 ? 2032 HOH A O 1 HETATM 4951 O O . HOH G 6 . ? 0.828 -28.633 -15.430 1.00 32.43 ? 2033 HOH A O 1 HETATM 4952 O O . HOH G 6 . ? 0.639 -28.257 -7.674 1.00 46.48 ? 2034 HOH A O 1 HETATM 4953 O O . HOH G 6 . ? -6.287 -23.470 -33.745 1.00 30.06 ? 2035 HOH A O 1 HETATM 4954 O O . HOH G 6 . ? 5.974 -26.901 -19.447 1.00 18.48 ? 2036 HOH A O 1 HETATM 4955 O O . HOH G 6 . ? 5.966 -33.022 -15.504 1.00 43.26 ? 2037 HOH A O 1 HETATM 4956 O O . HOH G 6 . ? 2.917 -33.649 -18.237 1.00 27.03 ? 2038 HOH A O 1 HETATM 4957 O O . HOH G 6 . ? -10.046 -14.615 -17.832 1.00 25.45 ? 2039 HOH A O 1 HETATM 4958 O O . HOH G 6 . ? 0.386 -9.340 -19.472 1.00 27.89 ? 2040 HOH A O 1 HETATM 4959 O O . HOH G 6 . ? 0.619 -22.619 -17.742 1.00 28.15 ? 2041 HOH A O 1 HETATM 4960 O O . HOH G 6 . ? -4.993 -24.564 -14.748 1.00 41.55 ? 2042 HOH A O 1 HETATM 4961 O O . HOH G 6 . ? -2.081 -22.663 -14.749 1.00 42.56 ? 2043 HOH A O 1 HETATM 4962 O O . HOH G 6 . ? -4.916 -25.821 -11.524 1.00 35.72 ? 2044 HOH A O 1 HETATM 4963 O O . HOH G 6 . ? 4.927 -17.516 -12.813 1.00 25.73 ? 2045 HOH A O 1 HETATM 4964 O O . HOH G 6 . ? -8.520 -19.798 -4.524 1.00 44.61 ? 2046 HOH A O 1 HETATM 4965 O O . HOH G 6 . ? -10.481 -18.157 -7.379 1.00 43.39 ? 2047 HOH A O 1 HETATM 4966 O O . HOH G 6 . ? 10.150 -24.463 -23.580 1.00 28.62 ? 2048 HOH A O 1 HETATM 4967 O O . HOH G 6 . ? -7.380 -14.539 -4.079 1.00 43.66 ? 2049 HOH A O 1 HETATM 4968 O O . HOH G 6 . ? -10.481 -16.774 -9.872 1.00 31.78 ? 2050 HOH A O 1 HETATM 4969 O O . HOH G 6 . ? 5.902 -16.019 -18.225 1.00 45.89 ? 2051 HOH A O 1 HETATM 4970 O O . HOH G 6 . ? -0.497 -14.971 -14.604 1.00 30.64 ? 2052 HOH A O 1 HETATM 4971 O O . HOH G 6 . ? 6.041 -20.188 -28.593 1.00 34.28 ? 2053 HOH A O 1 HETATM 4972 O O . HOH G 6 . ? 9.095 -22.159 -29.113 1.00 40.25 ? 2054 HOH A O 1 HETATM 4973 O O . HOH G 6 . ? 16.103 -17.821 11.104 1.00 42.89 ? 2055 HOH A O 1 HETATM 4974 O O . HOH G 6 . ? 0.499 -16.755 -27.820 1.00 20.63 ? 2056 HOH A O 1 HETATM 4975 O O . HOH G 6 . ? 4.471 -10.930 -25.220 1.00 28.79 ? 2057 HOH A O 1 HETATM 4976 O O . HOH G 6 . ? 16.410 -15.016 3.758 1.00 41.90 ? 2058 HOH A O 1 HETATM 4977 O O . HOH G 6 . ? 10.977 -13.294 3.414 1.00 32.40 ? 2059 HOH A O 1 HETATM 4978 O O . HOH G 6 . ? 15.344 -25.808 -2.118 1.00 40.60 ? 2060 HOH A O 1 HETATM 4979 O O . HOH G 6 . ? -2.769 -7.578 -30.534 1.00 49.94 ? 2061 HOH A O 1 HETATM 4980 O O . HOH G 6 . ? 3.761 -7.967 0.879 1.00 36.73 ? 2062 HOH A O 1 HETATM 4981 O O . HOH G 6 . ? 0.576 -10.309 0.567 1.00 51.31 ? 2063 HOH A O 1 HETATM 4982 O O . HOH G 6 . ? 4.215 -9.031 -5.296 1.00 29.30 ? 2064 HOH A O 1 HETATM 4983 O O . HOH G 6 . ? 2.063 -6.527 -9.087 1.00 22.17 ? 2065 HOH A O 1 HETATM 4984 O O . HOH G 6 . ? 3.798 -10.718 -9.214 1.00 44.98 ? 2066 HOH A O 1 HETATM 4985 O O . HOH G 6 . ? 3.028 -8.925 -13.084 1.00 41.08 ? 2067 HOH A O 1 HETATM 4986 O O . HOH G 6 . ? 5.670 -5.965 -10.028 1.00 23.52 ? 2068 HOH A O 1 HETATM 4987 O O . HOH G 6 . ? 4.450 -6.657 -14.040 1.00 36.78 ? 2069 HOH A O 1 HETATM 4988 O O . HOH G 6 . ? 1.694 -9.921 -37.204 1.00 38.83 ? 2070 HOH A O 1 HETATM 4989 O O . HOH G 6 . ? -11.111 -13.348 -6.357 1.00 38.22 ? 2071 HOH A O 1 HETATM 4990 O O . HOH G 6 . ? -11.383 -9.145 -4.107 1.00 41.92 ? 2072 HOH A O 1 HETATM 4991 O O . HOH G 6 . ? -1.829 -8.319 -35.950 1.00 40.23 ? 2073 HOH A O 1 HETATM 4992 O O . HOH G 6 . ? 0.947 -8.785 -16.555 1.00 45.81 ? 2074 HOH A O 1 HETATM 4993 O O . HOH G 6 . ? -5.290 -13.984 -35.157 1.00 32.92 ? 2075 HOH A O 1 HETATM 4994 O O . HOH G 6 . ? -4.599 -11.042 -35.931 1.00 34.23 ? 2076 HOH A O 1 HETATM 4995 O O . HOH G 6 . ? -6.914 -19.900 -31.669 1.00 34.28 ? 2077 HOH A O 1 HETATM 4996 O O . HOH G 6 . ? -5.003 -21.319 -32.857 1.00 42.17 ? 2078 HOH A O 1 HETATM 4997 O O . HOH G 6 . ? -2.343 -0.223 -33.703 1.00 32.86 ? 2079 HOH A O 1 HETATM 4998 O O . HOH G 6 . ? -2.432 -0.243 -36.645 1.00 48.76 ? 2080 HOH A O 1 HETATM 4999 O O . HOH G 6 . ? -4.782 -5.734 -28.416 1.00 39.07 ? 2081 HOH A O 1 HETATM 5000 O O . HOH G 6 . ? -6.503 -6.106 -26.017 1.00 27.93 ? 2082 HOH A O 1 HETATM 5001 O O . HOH G 6 . ? 8.953 -0.637 -31.588 1.00 36.99 ? 2083 HOH A O 1 HETATM 5002 O O . HOH G 6 . ? -8.039 -14.747 -23.988 1.00 33.48 ? 2084 HOH A O 1 HETATM 5003 O O . HOH G 6 . ? 15.083 16.099 -49.142 1.00 42.74 ? 2085 HOH A O 1 HETATM 5004 O O . HOH G 6 . ? 18.986 15.689 -47.889 1.00 36.24 ? 2086 HOH A O 1 HETATM 5005 O O . HOH G 6 . ? 0.379 -8.519 -23.191 1.00 34.68 ? 2087 HOH A O 1 HETATM 5006 O O . HOH G 6 . ? -0.397 11.817 -49.514 1.00 54.45 ? 2088 HOH A O 1 HETATM 5007 O O . HOH G 6 . ? -7.832 -13.765 -19.790 1.00 37.07 ? 2089 HOH A O 1 HETATM 5008 O O . HOH G 6 . ? -1.574 -9.069 -21.416 1.00 26.96 ? 2090 HOH A O 1 HETATM 5009 O O . HOH G 6 . ? -7.225 -11.565 -24.225 1.00 46.89 ? 2091 HOH A O 1 HETATM 5010 O O . HOH G 6 . ? -10.050 -17.539 -18.072 1.00 34.40 ? 2092 HOH A O 1 HETATM 5011 O O . HOH G 6 . ? -9.166 -15.616 -21.635 1.00 25.41 ? 2093 HOH A O 1 HETATM 5012 O O . HOH G 6 . ? -10.273 -20.972 -17.831 1.00 41.97 ? 2094 HOH A O 1 HETATM 5013 O O . HOH G 6 . ? 16.603 -3.882 -39.234 1.00 32.08 ? 2095 HOH A O 1 HETATM 5014 O O . HOH G 6 . ? 18.907 1.458 -39.258 1.00 36.23 ? 2096 HOH A O 1 HETATM 5015 O O . HOH G 6 . ? 15.970 3.730 -43.032 1.00 38.48 ? 2097 HOH A O 1 HETATM 5016 O O . HOH G 6 . ? 14.698 -3.825 -41.380 1.00 30.27 ? 2098 HOH A O 1 HETATM 5017 O O . HOH G 6 . ? 15.655 -2.384 -43.503 1.00 37.36 ? 2099 HOH A O 1 HETATM 5018 O O . HOH G 6 . ? 17.798 -0.108 -41.939 1.00 41.81 ? 2100 HOH A O 1 HETATM 5019 O O . HOH G 6 . ? 22.724 9.416 -42.512 1.00 45.51 ? 2101 HOH A O 1 HETATM 5020 O O . HOH G 6 . ? -8.567 -19.194 -16.054 1.00 41.69 ? 2102 HOH A O 1 HETATM 5021 O O . HOH G 6 . ? -8.031 -15.767 -13.633 1.00 21.44 ? 2103 HOH A O 1 HETATM 5022 O O . HOH G 6 . ? -6.023 -22.452 -13.172 1.00 32.10 ? 2104 HOH A O 1 HETATM 5023 O O . HOH G 6 . ? -3.424 -23.694 -16.854 1.00 33.25 ? 2105 HOH A O 1 HETATM 5024 O O . HOH G 6 . ? 26.391 14.169 -39.793 1.00 46.26 ? 2106 HOH A O 1 HETATM 5025 O O . HOH G 6 . ? 26.248 2.064 -39.063 1.00 40.64 ? 2107 HOH A O 1 HETATM 5026 O O . HOH G 6 . ? 20.494 18.717 -42.501 1.00 42.01 ? 2108 HOH A O 1 HETATM 5027 O O . HOH G 6 . ? 23.697 17.625 -41.799 1.00 41.96 ? 2109 HOH A O 1 HETATM 5028 O O . HOH G 6 . ? 22.007 23.612 -38.592 1.00 43.53 ? 2110 HOH A O 1 HETATM 5029 O O . HOH G 6 . ? 24.680 14.948 -41.794 1.00 45.48 ? 2111 HOH A O 1 HETATM 5030 O O . HOH G 6 . ? -8.385 -19.792 -7.464 1.00 40.42 ? 2112 HOH A O 1 HETATM 5031 O O . HOH G 6 . ? 0.593 -17.493 -4.826 1.00 41.27 ? 2113 HOH A O 1 HETATM 5032 O O . HOH G 6 . ? 3.750 -17.436 -10.320 1.00 38.35 ? 2114 HOH A O 1 HETATM 5033 O O . HOH G 6 . ? -5.936 -16.439 -2.456 1.00 33.55 ? 2115 HOH A O 1 HETATM 5034 O O . HOH G 6 . ? -8.371 -15.592 -10.932 1.00 26.83 ? 2116 HOH A O 1 HETATM 5035 O O . HOH G 6 . ? -5.398 9.704 -30.299 1.00 43.82 ? 2117 HOH A O 1 HETATM 5036 O O . HOH G 6 . ? -5.985 -23.768 -10.714 1.00 45.74 ? 2118 HOH A O 1 HETATM 5037 O O . HOH G 6 . ? -8.239 -2.436 -23.674 1.00 42.43 ? 2119 HOH A O 1 HETATM 5038 O O . HOH G 6 . ? -11.054 0.950 -8.848 1.00 37.45 ? 2120 HOH A O 1 HETATM 5039 O O . HOH G 6 . ? -8.212 4.386 -8.662 1.00 36.62 ? 2121 HOH A O 1 HETATM 5040 O O . HOH G 6 . ? -7.933 1.340 -5.762 1.00 25.44 ? 2122 HOH A O 1 HETATM 5041 O O . HOH G 6 . ? 0.449 -18.242 4.228 1.00 40.34 ? 2123 HOH A O 1 HETATM 5042 O O . HOH G 6 . ? -6.219 5.045 -10.235 1.00 32.41 ? 2124 HOH A O 1 HETATM 5043 O O . HOH G 6 . ? -9.316 -0.436 -4.376 1.00 31.83 ? 2125 HOH A O 1 HETATM 5044 O O . HOH G 6 . ? -10.670 -4.310 -4.031 1.00 31.48 ? 2126 HOH A O 1 HETATM 5045 O O . HOH G 6 . ? -11.399 -6.692 -5.428 1.00 42.18 ? 2127 HOH A O 1 HETATM 5046 O O . HOH G 6 . ? -9.803 0.699 -1.909 1.00 41.49 ? 2128 HOH A O 1 HETATM 5047 O O . HOH G 6 . ? 3.772 -6.863 -6.919 1.00 30.21 ? 2129 HOH A O 1 HETATM 5048 O O . HOH G 6 . ? 0.083 -20.060 8.542 1.00 36.19 ? 2130 HOH A O 1 HETATM 5049 O O . HOH G 6 . ? 5.006 -0.844 1.480 1.00 27.64 ? 2131 HOH A O 1 HETATM 5050 O O . HOH G 6 . ? 8.554 0.678 -0.209 1.00 26.68 ? 2132 HOH A O 1 HETATM 5051 O O . HOH G 6 . ? 0.392 7.496 -1.048 1.00 36.68 ? 2133 HOH A O 1 HETATM 5052 O O . HOH G 6 . ? 5.907 1.195 2.885 1.00 37.95 ? 2134 HOH A O 1 HETATM 5053 O O . HOH G 6 . ? 2.435 -19.036 9.713 1.00 33.09 ? 2135 HOH A O 1 HETATM 5054 O O . HOH G 6 . ? 11.018 -5.444 2.970 1.00 38.55 ? 2136 HOH A O 1 HETATM 5055 O O . HOH G 6 . ? 10.064 -19.236 13.108 1.00 35.47 ? 2137 HOH A O 1 HETATM 5056 O O . HOH G 6 . ? 8.790 -16.362 11.715 1.00 37.07 ? 2138 HOH A O 1 HETATM 5057 O O . HOH G 6 . ? 5.856 -8.818 -10.216 1.00 39.87 ? 2139 HOH A O 1 HETATM 5058 O O . HOH G 6 . ? 13.046 -6.609 4.274 1.00 45.28 ? 2140 HOH A O 1 HETATM 5059 O O . HOH G 6 . ? 16.586 -8.058 5.033 1.00 40.62 ? 2141 HOH A O 1 HETATM 5060 O O . HOH G 6 . ? 18.923 -7.358 3.630 1.00 25.28 ? 2142 HOH A O 1 HETATM 5061 O O . HOH G 6 . ? 22.432 1.627 3.613 1.00 41.04 ? 2143 HOH A O 1 HETATM 5062 O O . HOH G 6 . ? 9.740 4.904 -0.882 1.00 25.42 ? 2144 HOH A O 1 HETATM 5063 O O . HOH G 6 . ? 10.902 8.103 3.488 1.00 48.12 ? 2145 HOH A O 1 HETATM 5064 O O . HOH G 6 . ? 15.104 7.231 5.022 1.00 33.22 ? 2146 HOH A O 1 HETATM 5065 O O . HOH G 6 . ? 17.946 -3.302 7.999 1.00 40.47 ? 2147 HOH A O 1 HETATM 5066 O O . HOH G 6 . ? 9.654 -25.243 14.924 1.00 47.60 ? 2148 HOH A O 1 HETATM 5067 O O . HOH G 6 . ? 4.017 -21.945 17.028 1.00 37.32 ? 2149 HOH A O 1 HETATM 5068 O O . HOH G 6 . ? 21.598 5.395 3.585 1.00 43.67 ? 2150 HOH A O 1 HETATM 5069 O O . HOH G 6 . ? 13.895 -19.457 12.040 1.00 29.85 ? 2151 HOH A O 1 HETATM 5070 O O . HOH G 6 . ? 18.094 14.799 -2.298 1.00 40.55 ? 2152 HOH A O 1 HETATM 5071 O O . HOH G 6 . ? 25.141 7.337 -0.776 1.00 27.59 ? 2153 HOH A O 1 HETATM 5072 O O . HOH G 6 . ? 23.642 3.875 2.352 1.00 36.82 ? 2154 HOH A O 1 HETATM 5073 O O . HOH G 6 . ? 17.428 -21.330 8.739 1.00 33.23 ? 2155 HOH A O 1 HETATM 5074 O O . HOH G 6 . ? 23.590 11.998 1.348 1.00 52.44 ? 2156 HOH A O 1 HETATM 5075 O O . HOH G 6 . ? 17.783 6.841 4.190 1.00 31.05 ? 2157 HOH A O 1 HETATM 5076 O O . HOH G 6 . ? 15.657 -25.660 4.853 1.00 40.72 ? 2158 HOH A O 1 HETATM 5077 O O . HOH G 6 . ? 17.580 -21.632 6.020 1.00 30.71 ? 2159 HOH A O 1 HETATM 5078 O O . HOH G 6 . ? 20.182 17.912 -5.430 1.00 36.25 ? 2160 HOH A O 1 HETATM 5079 O O . HOH G 6 . ? 30.638 13.037 -9.668 1.00 41.01 ? 2161 HOH A O 1 HETATM 5080 O O . HOH G 6 . ? 30.428 17.191 -8.944 1.00 38.05 ? 2162 HOH A O 1 HETATM 5081 O O . HOH G 6 . ? 13.764 -13.684 3.663 1.00 25.64 ? 2163 HOH A O 1 HETATM 5082 O O . HOH G 6 . ? 24.857 22.900 -11.018 1.00 41.08 ? 2164 HOH A O 1 HETATM 5083 O O . HOH G 6 . ? 29.405 21.370 -10.013 1.00 35.03 ? 2165 HOH A O 1 HETATM 5084 O O . HOH G 6 . ? 24.400 21.542 -8.527 1.00 39.71 ? 2166 HOH A O 1 HETATM 5085 O O . HOH G 6 . ? 16.981 -17.683 3.762 1.00 33.89 ? 2167 HOH A O 1 HETATM 5086 O O . HOH G 6 . ? 16.530 -23.467 -1.353 1.00 33.36 ? 2168 HOH A O 1 HETATM 5087 O O . HOH G 6 . ? 17.275 -18.873 1.410 1.00 24.94 ? 2169 HOH A O 1 HETATM 5088 O O . HOH G 6 . ? 14.891 -25.342 2.327 1.00 43.63 ? 2170 HOH A O 1 HETATM 5089 O O . HOH G 6 . ? 32.567 24.451 -11.503 1.00 40.58 ? 2171 HOH A O 1 HETATM 5090 O O . HOH G 6 . ? 30.669 26.808 -14.171 1.00 42.84 ? 2172 HOH A O 1 HETATM 5091 O O . HOH G 6 . ? 9.622 -15.018 5.388 1.00 33.78 ? 2173 HOH A O 1 HETATM 5092 O O . HOH G 6 . ? 11.218 -15.778 12.784 1.00 46.41 ? 2174 HOH A O 1 HETATM 5093 O O . HOH G 6 . ? 10.006 -13.917 0.752 1.00 27.86 ? 2175 HOH A O 1 HETATM 5094 O O . HOH G 6 . ? 12.783 -14.835 -2.830 1.00 25.70 ? 2176 HOH A O 1 HETATM 5095 O O . HOH G 6 . ? 11.630 -13.051 -1.267 1.00 30.16 ? 2177 HOH A O 1 HETATM 5096 O O . HOH G 6 . ? 16.589 -11.628 -3.638 1.00 16.54 ? 2178 HOH A O 1 HETATM 5097 O O . HOH G 6 . ? 6.430 -7.417 1.460 1.00 33.82 ? 2179 HOH A O 1 HETATM 5098 O O . HOH G 6 . ? 13.047 27.879 -24.416 1.00 37.65 ? 2180 HOH A O 1 HETATM 5099 O O . HOH G 6 . ? 7.190 -13.235 -4.820 1.00 38.63 ? 2181 HOH A O 1 HETATM 5100 O O . HOH G 6 . ? 2.811 -15.730 -5.850 1.00 46.54 ? 2182 HOH A O 1 HETATM 5101 O O . HOH G 6 . ? -1.905 -13.522 -0.353 1.00 35.04 ? 2183 HOH A O 1 HETATM 5102 O O . HOH G 6 . ? -0.865 -11.216 -1.751 1.00 41.23 ? 2184 HOH A O 1 HETATM 5103 O O . HOH G 6 . ? 9.097 -11.921 -1.945 1.00 44.03 ? 2185 HOH A O 1 HETATM 5104 O O . HOH G 6 . ? 10.369 -8.557 -2.212 1.00 30.67 ? 2186 HOH A O 1 HETATM 5105 O O . HOH G 6 . ? 10.622 -9.900 0.290 1.00 41.73 ? 2187 HOH A O 1 HETATM 5106 O O . HOH G 6 . ? 1.875 -8.766 -4.001 1.00 27.29 ? 2188 HOH A O 1 HETATM 5107 O O . HOH G 6 . ? 0.988 -14.314 -8.554 1.00 34.34 ? 2189 HOH A O 1 HETATM 5108 O O . HOH G 6 . ? 1.870 -9.024 -10.602 1.00 25.33 ? 2190 HOH A O 1 HETATM 5109 O O . HOH G 6 . ? 3.395 -4.493 -10.526 1.00 20.22 ? 2191 HOH A O 1 HETATM 5110 O O . HOH G 6 . ? 4.486 -3.977 -13.195 1.00 22.79 ? 2192 HOH A O 1 HETATM 5111 O O . HOH G 6 . ? -7.194 -11.675 -3.576 1.00 45.68 ? 2193 HOH A O 1 HETATM 5112 O O . HOH G 6 . ? -9.968 -11.004 -5.590 1.00 37.27 ? 2194 HOH A O 1 HETATM 5113 O O . HOH G 6 . ? -15.852 -13.835 -13.455 1.00 47.51 ? 2195 HOH A O 1 HETATM 5114 O O . HOH G 6 . ? -14.658 -11.867 -11.409 1.00 38.45 ? 2196 HOH A O 1 HETATM 5115 O O . HOH G 6 . ? -11.938 -14.123 -9.033 1.00 32.21 ? 2197 HOH A O 1 HETATM 5116 O O . HOH G 6 . ? -8.797 -13.761 -15.341 1.00 20.84 ? 2198 HOH A O 1 HETATM 5117 O O . HOH G 6 . ? -10.034 -17.657 -14.153 1.00 31.58 ? 2199 HOH A O 1 HETATM 5118 O O . HOH G 6 . ? -16.562 -18.495 -12.422 1.00 45.71 ? 2200 HOH A O 1 HETATM 5119 O O . HOH G 6 . ? -13.312 -5.868 -14.842 1.00 35.85 ? 2201 HOH A O 1 HETATM 5120 O O . HOH G 6 . ? -13.039 -8.789 -18.037 1.00 33.74 ? 2202 HOH A O 1 HETATM 5121 O O . HOH G 6 . ? 40.301 9.582 -35.590 1.00 48.02 ? 2203 HOH A O 1 HETATM 5122 O O . HOH G 6 . ? 33.507 5.540 -38.513 1.00 37.24 ? 2204 HOH A O 1 HETATM 5123 O O . HOH G 6 . ? 29.344 4.979 -38.958 1.00 43.95 ? 2205 HOH A O 1 HETATM 5124 O O . HOH G 6 . ? 36.034 3.335 -39.357 1.00 34.57 ? 2206 HOH A O 1 HETATM 5125 O O . HOH G 6 . ? 37.549 5.865 -38.242 1.00 47.34 ? 2207 HOH A O 1 HETATM 5126 O O . HOH G 6 . ? -13.026 -2.945 -11.732 1.00 41.14 ? 2208 HOH A O 1 HETATM 5127 O O . HOH G 6 . ? 0.134 -10.779 -14.713 1.00 39.24 ? 2209 HOH A O 1 HETATM 5128 O O . HOH G 6 . ? 22.587 -0.429 -39.366 1.00 38.66 ? 2210 HOH A O 1 HETATM 5129 O O . HOH G 6 . ? -7.904 -11.199 -20.947 1.00 25.66 ? 2211 HOH A O 1 HETATM 5130 O O . HOH G 6 . ? -11.472 -1.765 -20.249 1.00 32.49 ? 2212 HOH A O 1 HETATM 5131 O O . HOH G 6 . ? 24.470 -20.889 -34.714 1.00 42.67 ? 2213 HOH A O 1 HETATM 5132 O O . HOH G 6 . ? 28.537 -21.061 -31.248 1.00 44.66 ? 2214 HOH A O 1 HETATM 5133 O O . HOH G 6 . ? 33.624 -19.591 -11.096 1.00 37.24 ? 2215 HOH A O 1 HETATM 5134 O O . HOH G 6 . ? 27.083 -22.636 -13.100 1.00 33.41 ? 2216 HOH A O 1 HETATM 5135 O O . HOH G 6 . ? -4.039 -1.440 -29.500 1.00 22.27 ? 2217 HOH A O 1 HETATM 5136 O O . HOH G 6 . ? 27.901 -25.697 -20.255 1.00 37.80 ? 2218 HOH A O 1 HETATM 5137 O O . HOH G 6 . ? 1.916 2.669 -27.258 1.00 16.89 ? 2219 HOH A O 1 HETATM 5138 O O . HOH G 6 . ? 5.638 -6.057 -25.073 1.00 40.29 ? 2220 HOH A O 1 HETATM 5139 O O . HOH G 6 . ? -2.962 -2.395 -31.923 1.00 31.60 ? 2221 HOH A O 1 HETATM 5140 O O . HOH G 6 . ? -0.022 1.425 -33.581 1.00 20.99 ? 2222 HOH A O 1 HETATM 5141 O O . HOH G 6 . ? -1.286 4.418 -32.652 1.00 25.54 ? 2223 HOH A O 1 HETATM 5142 O O . HOH G 6 . ? -4.433 1.325 -30.430 1.00 43.50 ? 2224 HOH A O 1 HETATM 5143 O O . HOH G 6 . ? 17.488 -10.159 -42.794 1.00 49.70 ? 2225 HOH A O 1 HETATM 5144 O O . HOH G 6 . ? 17.953 -6.207 -40.409 1.00 37.18 ? 2226 HOH A O 1 HETATM 5145 O O . HOH G 6 . ? 14.311 -6.441 -42.281 1.00 40.43 ? 2227 HOH A O 1 HETATM 5146 O O . HOH G 6 . ? 7.109 1.705 -31.903 1.00 21.92 ? 2228 HOH A O 1 HETATM 5147 O O . HOH G 6 . ? 5.408 -1.020 -36.577 1.00 19.72 ? 2229 HOH A O 1 HETATM 5148 O O . HOH G 6 . ? 5.697 -4.473 -35.720 1.00 27.44 ? 2230 HOH A O 1 HETATM 5149 O O . HOH G 6 . ? 1.711 -1.573 -38.426 1.00 42.60 ? 2231 HOH A O 1 HETATM 5150 O O . HOH G 6 . ? 0.488 3.407 -36.825 1.00 30.06 ? 2232 HOH A O 1 HETATM 5151 O O . HOH G 6 . ? 7.109 1.238 -34.598 1.00 18.94 ? 2233 HOH A O 1 HETATM 5152 O O . HOH G 6 . ? 1.254 5.296 -41.161 1.00 42.43 ? 2234 HOH A O 1 HETATM 5153 O O . HOH G 6 . ? 4.676 -4.751 -39.933 1.00 44.51 ? 2235 HOH A O 1 HETATM 5154 O O . HOH G 6 . ? 7.603 -3.261 -37.577 1.00 43.06 ? 2236 HOH A O 1 HETATM 5155 O O . HOH G 6 . ? 2.612 9.589 -40.089 1.00 26.70 ? 2237 HOH A O 1 HETATM 5156 O O . HOH G 6 . ? 0.116 8.113 -40.655 1.00 39.01 ? 2238 HOH A O 1 HETATM 5157 O O . HOH G 6 . ? 12.184 5.501 -45.405 1.00 26.88 ? 2239 HOH A O 1 HETATM 5158 O O . HOH G 6 . ? 12.682 11.461 -43.815 1.00 25.56 ? 2240 HOH A O 1 HETATM 5159 O O . HOH G 6 . ? 13.439 7.254 -43.501 1.00 31.80 ? 2241 HOH A O 1 HETATM 5160 O O . HOH G 6 . ? 6.171 16.108 -44.550 1.00 36.87 ? 2242 HOH A O 1 HETATM 5161 O O . HOH G 6 . ? 9.654 17.847 -46.434 1.00 44.79 ? 2243 HOH A O 1 HETATM 5162 O O . HOH G 6 . ? 9.285 21.241 -42.674 1.00 43.76 ? 2244 HOH A O 1 HETATM 5163 O O . HOH G 6 . ? 13.646 20.131 -43.710 1.00 28.64 ? 2245 HOH A O 1 HETATM 5164 O O . HOH G 6 . ? 8.006 13.808 -52.283 1.00 40.16 ? 2246 HOH A O 1 HETATM 5165 O O . HOH G 6 . ? 5.639 14.548 -49.476 1.00 41.43 ? 2247 HOH A O 1 HETATM 5166 O O . HOH G 6 . ? 11.329 15.011 -51.658 1.00 30.99 ? 2248 HOH A O 1 HETATM 5167 O O . HOH G 6 . ? 16.937 14.007 -48.750 1.00 24.55 ? 2249 HOH A O 1 HETATM 5168 O O . HOH G 6 . ? 18.012 13.954 -43.650 1.00 38.58 ? 2250 HOH A O 1 HETATM 5169 O O . HOH G 6 . ? 4.656 12.502 -52.432 1.00 38.04 ? 2251 HOH A O 1 HETATM 5170 O O . HOH G 6 . ? 31.397 3.847 -25.784 1.00 29.54 ? 2252 HOH A O 1 HETATM 5171 O O . HOH G 6 . ? 22.956 -1.681 -23.606 1.00 33.10 ? 2253 HOH A O 1 HETATM 5172 O O . HOH G 6 . ? -0.020 9.645 -46.953 1.00 46.21 ? 2254 HOH A O 1 HETATM 5173 O O . HOH G 6 . ? 4.799 5.964 -51.327 1.00 38.37 ? 2255 HOH A O 1 HETATM 5174 O O . HOH G 6 . ? 2.700 3.534 -47.189 1.00 32.59 ? 2256 HOH A O 1 HETATM 5175 O O . HOH G 6 . ? 0.013 6.549 -49.449 1.00 48.60 ? 2257 HOH A O 1 HETATM 5176 O O . HOH G 6 . ? 8.115 2.677 -50.382 1.00 36.05 ? 2258 HOH A O 1 HETATM 5177 O O . HOH G 6 . ? 9.841 0.896 -44.118 1.00 47.66 ? 2259 HOH A O 1 HETATM 5178 O O . HOH G 6 . ? 9.475 -1.123 -40.996 1.00 40.07 ? 2260 HOH A O 1 HETATM 5179 O O . HOH G 6 . ? 5.479 1.619 -49.304 1.00 41.79 ? 2261 HOH A O 1 HETATM 5180 O O . HOH G 6 . ? 25.416 -23.254 -8.467 1.00 44.68 ? 2262 HOH A O 1 HETATM 5181 O O . HOH G 6 . ? 15.679 -27.215 -4.529 1.00 38.55 ? 2263 HOH A O 1 HETATM 5182 O O . HOH G 6 . ? 9.223 -0.771 -34.364 1.00 27.53 ? 2264 HOH A O 1 HETATM 5183 O O . HOH G 6 . ? 16.822 0.620 -34.599 1.00 36.13 ? 2265 HOH A O 1 HETATM 5184 O O . HOH G 6 . ? 16.457 -3.485 -36.603 1.00 27.40 ? 2266 HOH A O 1 HETATM 5185 O O . HOH G 6 . ? 17.286 -2.918 -32.908 1.00 28.75 ? 2267 HOH A O 1 HETATM 5186 O O . HOH G 6 . ? 13.993 -1.510 -30.720 1.00 28.41 ? 2268 HOH A O 1 HETATM 5187 O O . HOH G 6 . ? 17.875 2.231 -36.673 1.00 38.09 ? 2269 HOH A O 1 HETATM 5188 O O . HOH G 6 . ? 13.737 -8.565 -13.182 1.00 30.39 ? 2270 HOH A O 1 HETATM 5189 O O . HOH G 6 . ? 15.107 6.080 -41.744 1.00 20.39 ? 2271 HOH A O 1 HETATM 5190 O O . HOH G 6 . ? 12.201 -2.809 -41.398 1.00 34.22 ? 2272 HOH A O 1 HETATM 5191 O O . HOH G 6 . ? 14.453 -0.077 -43.480 1.00 38.88 ? 2273 HOH A O 1 HETATM 5192 O O . HOH G 6 . ? 17.724 7.038 -32.181 1.00 32.09 ? 2274 HOH A O 1 HETATM 5193 O O . HOH G 6 . ? 19.563 4.034 -35.150 1.00 35.49 ? 2275 HOH A O 1 HETATM 5194 O O . HOH G 6 . ? 17.088 -0.439 -31.407 1.00 44.52 ? 2276 HOH A O 1 HETATM 5195 O O . HOH G 6 . ? 16.555 3.943 -29.574 1.00 34.61 ? 2277 HOH A O 1 HETATM 5196 O O . HOH G 6 . ? 14.846 1.235 -28.587 1.00 45.30 ? 2278 HOH A O 1 HETATM 5197 O O . HOH G 6 . ? 18.147 9.933 -41.973 1.00 35.85 ? 2279 HOH A O 1 HETATM 5198 O O . HOH G 6 . ? 20.617 10.905 -41.580 1.00 43.84 ? 2280 HOH A O 1 HETATM 5199 O O . HOH G 6 . ? 18.608 13.901 -32.704 1.00 18.85 ? 2281 HOH A O 1 HETATM 5200 O O . HOH G 6 . ? 25.255 9.069 -34.838 1.00 38.40 ? 2282 HOH A O 1 HETATM 5201 O O . HOH G 6 . ? 44.647 -6.053 -24.151 1.00 44.97 ? 2283 HOH A O 1 HETATM 5202 O O . HOH G 6 . ? 24.779 11.929 -38.938 1.00 27.96 ? 2284 HOH A O 1 HETATM 5203 O O . HOH G 6 . ? 26.103 3.583 -36.730 1.00 44.69 ? 2285 HOH A O 1 HETATM 5204 O O . HOH G 6 . ? 22.046 4.357 -39.952 1.00 38.37 ? 2286 HOH A O 1 HETATM 5205 O O . HOH G 6 . ? 20.447 14.572 -34.438 1.00 32.93 ? 2287 HOH A O 1 HETATM 5206 O O . HOH G 6 . ? 21.030 16.108 -41.548 1.00 33.92 ? 2288 HOH A O 1 HETATM 5207 O O . HOH G 6 . ? 18.950 21.727 -38.874 1.00 22.52 ? 2289 HOH A O 1 HETATM 5208 O O . HOH G 6 . ? 22.583 20.727 -38.980 1.00 24.61 ? 2290 HOH A O 1 HETATM 5209 O O . HOH G 6 . ? 26.391 10.527 -37.131 1.00 39.46 ? 2291 HOH A O 1 HETATM 5210 O O . HOH G 6 . ? 15.686 22.455 -40.834 1.00 38.42 ? 2292 HOH A O 1 HETATM 5211 O O . HOH G 6 . ? 13.615 22.485 -33.974 1.00 24.48 ? 2293 HOH A O 1 HETATM 5212 O O . HOH G 6 . ? 8.707 19.683 -38.712 1.00 29.88 ? 2294 HOH A O 1 HETATM 5213 O O . HOH G 6 . ? 9.272 22.330 -36.133 1.00 41.75 ? 2295 HOH A O 1 HETATM 5214 O O . HOH G 6 . ? 6.640 18.718 -34.976 1.00 33.72 ? 2296 HOH A O 1 HETATM 5215 O O . HOH G 6 . ? 13.752 13.242 -28.706 1.00 20.24 ? 2297 HOH A O 1 HETATM 5216 O O . HOH G 6 . ? 4.687 18.230 -37.752 1.00 45.89 ? 2298 HOH A O 1 HETATM 5217 O O . HOH G 6 . ? 0.389 16.840 -32.819 1.00 27.95 ? 2299 HOH A O 1 HETATM 5218 O O . HOH G 6 . ? 2.142 19.095 -30.321 1.00 25.42 ? 2300 HOH A O 1 HETATM 5219 O O . HOH G 6 . ? 2.282 21.813 -31.364 1.00 42.59 ? 2301 HOH A O 1 HETATM 5220 O O . HOH G 6 . ? 6.384 13.464 -8.613 1.00 37.65 ? 2302 HOH A O 1 HETATM 5221 O O . HOH G 6 . ? 0.769 13.839 -35.952 1.00 45.13 ? 2303 HOH A O 1 HETATM 5222 O O . HOH G 6 . ? 7.144 11.589 -3.492 1.00 42.93 ? 2304 HOH A O 1 HETATM 5223 O O . HOH G 6 . ? 9.868 10.542 -23.460 1.00 18.74 ? 2305 HOH A O 1 HETATM 5224 O O . HOH G 6 . ? -2.946 10.220 -31.607 1.00 42.34 ? 2306 HOH A O 1 HETATM 5225 O O . HOH G 6 . ? -0.901 13.912 -29.463 1.00 18.95 ? 2307 HOH A O 1 HETATM 5226 O O . HOH G 6 . ? 6.847 21.474 -18.843 1.00 18.61 ? 2308 HOH A O 1 HETATM 5227 O O . HOH G 6 . ? 3.101 17.818 -11.230 1.00 41.75 ? 2309 HOH A O 1 HETATM 5228 O O . HOH G 6 . ? -7.100 6.040 -25.801 1.00 37.67 ? 2310 HOH A O 1 HETATM 5229 O O . HOH G 6 . ? -6.234 3.019 -28.959 1.00 37.19 ? 2311 HOH A O 1 HETATM 5230 O O . HOH G 6 . ? -4.849 15.117 -19.059 1.00 29.78 ? 2312 HOH A O 1 HETATM 5231 O O . HOH G 6 . ? -10.000 4.673 -19.266 1.00 29.20 ? 2313 HOH A O 1 HETATM 5232 O O . HOH G 6 . ? -7.929 -1.064 -26.350 1.00 40.30 ? 2314 HOH A O 1 HETATM 5233 O O . HOH G 6 . ? -6.898 6.430 -14.092 1.00 32.18 ? 2315 HOH A O 1 HETATM 5234 O O . HOH G 6 . ? 8.329 -6.738 -15.739 1.00 57.08 ? 2316 HOH A O 1 HETATM 5235 O O . HOH G 6 . ? 7.817 -5.487 -11.682 1.00 25.72 ? 2317 HOH A O 1 HETATM 5236 O O . HOH G 6 . ? 3.698 1.626 -17.134 1.00 13.95 ? 2318 HOH A O 1 HETATM 5237 O O . HOH G 6 . ? -8.333 1.644 -8.531 1.00 23.51 ? 2319 HOH A O 1 HETATM 5238 O O . HOH G 6 . ? -10.564 5.693 -10.053 1.00 47.17 ? 2320 HOH A O 1 HETATM 5239 O O . HOH G 6 . ? 0.228 -2.996 -8.240 1.00 16.84 ? 2321 HOH A O 1 HETATM 5240 O O . HOH G 6 . ? 2.792 -2.022 -9.337 1.00 18.12 ? 2322 HOH A O 1 HETATM 5241 O O . HOH G 6 . ? -1.020 1.969 -8.251 1.00 17.54 ? 2323 HOH A O 1 HETATM 5242 O O . HOH G 6 . ? -4.018 5.743 -8.757 1.00 26.00 ? 2324 HOH A O 1 HETATM 5243 O O . HOH G 6 . ? -8.260 -2.989 -3.999 1.00 25.60 ? 2325 HOH A O 1 HETATM 5244 O O . HOH G 6 . ? -13.916 -5.824 -6.600 1.00 42.30 ? 2326 HOH A O 1 HETATM 5245 O O . HOH G 6 . ? 41.559 -8.921 -5.696 1.00 42.11 ? 2327 HOH A O 1 HETATM 5246 O O . HOH G 6 . ? -8.278 -3.318 -1.078 1.00 32.40 ? 2328 HOH A O 1 HETATM 5247 O O . HOH G 6 . ? -4.866 -2.281 1.485 1.00 39.42 ? 2329 HOH A O 1 HETATM 5248 O O . HOH G 6 . ? -4.034 5.601 -1.269 1.00 42.88 ? 2330 HOH A O 1 HETATM 5249 O O . HOH G 6 . ? 2.093 -8.803 -1.192 1.00 38.47 ? 2331 HOH A O 1 HETATM 5250 O O . HOH G 6 . ? -0.009 -5.692 -7.604 1.00 23.16 ? 2332 HOH A O 1 HETATM 5251 O O . HOH G 6 . ? 1.412 -6.296 -5.284 1.00 23.09 ? 2333 HOH A O 1 HETATM 5252 O O . HOH G 6 . ? 2.472 -4.272 2.935 1.00 42.56 ? 2334 HOH A O 1 HETATM 5253 O O . HOH G 6 . ? -3.515 -0.009 0.962 1.00 41.00 ? 2335 HOH A O 1 HETATM 5254 O O . HOH G 6 . ? 2.456 0.142 1.158 1.00 25.92 ? 2336 HOH A O 1 HETATM 5255 O O . HOH G 6 . ? -2.986 4.872 -4.482 1.00 35.54 ? 2337 HOH A O 1 HETATM 5256 O O . HOH G 6 . ? 2.972 3.366 2.130 1.00 41.77 ? 2338 HOH A O 1 HETATM 5257 O O . HOH G 6 . ? 6.911 -1.432 -0.421 1.00 21.43 ? 2339 HOH A O 1 HETATM 5258 O O . HOH G 6 . ? 2.725 6.227 -0.541 1.00 38.87 ? 2340 HOH A O 1 HETATM 5259 O O . HOH G 6 . ? 5.758 4.399 1.252 1.00 54.06 ? 2341 HOH A O 1 HETATM 5260 O O . HOH G 6 . ? 6.357 -5.883 -7.319 1.00 27.41 ? 2342 HOH A O 1 HETATM 5261 O O . HOH G 6 . ? 10.657 -3.288 -8.836 1.00 19.78 ? 2343 HOH A O 1 HETATM 5262 O O . HOH G 6 . ? 11.807 -2.363 -0.368 1.00 22.62 ? 2344 HOH A O 1 HETATM 5263 O O . HOH G 6 . ? 10.251 -7.042 0.761 1.00 37.23 ? 2345 HOH A O 1 HETATM 5264 O O . HOH G 6 . ? 7.773 -3.549 0.974 1.00 23.41 ? 2346 HOH A O 1 HETATM 5265 O O . HOH G 6 . ? 7.099 -8.587 -4.318 1.00 34.08 ? 2347 HOH A O 1 HETATM 5266 O O . HOH G 6 . ? 18.100 -13.623 5.312 1.00 36.79 ? 2348 HOH A O 1 HETATM 5267 O O . HOH G 6 . ? 7.601 -10.201 -8.177 1.00 44.08 ? 2349 HOH A O 1 HETATM 5268 O O . HOH G 6 . ? 11.912 -8.998 -8.905 1.00 39.71 ? 2350 HOH A O 1 HETATM 5269 O O . HOH G 6 . ? 29.378 1.993 1.101 1.00 39.98 ? 2351 HOH A O 1 HETATM 5270 O O . HOH G 6 . ? 15.419 -5.160 4.642 1.00 37.89 ? 2352 HOH A O 1 HETATM 5271 O O . HOH G 6 . ? 18.012 -5.781 1.493 1.00 23.44 ? 2353 HOH A O 1 HETATM 5272 O O . HOH G 6 . ? 13.767 -9.202 3.307 1.00 33.44 ? 2354 HOH A O 1 HETATM 5273 O O . HOH G 6 . ? 16.507 -8.354 -2.567 1.00 19.14 ? 2355 HOH A O 1 HETATM 5274 O O . HOH G 6 . ? 29.699 7.692 -1.056 1.00 45.64 ? 2356 HOH A O 1 HETATM 5275 O O . HOH G 6 . ? 32.470 9.870 -4.227 1.00 45.03 ? 2357 HOH A O 1 HETATM 5276 O O . HOH G 6 . ? 11.397 0.670 -0.531 1.00 26.98 ? 2358 HOH A O 1 HETATM 5277 O O . HOH G 6 . ? 16.831 -0.668 5.401 1.00 47.71 ? 2359 HOH A O 1 HETATM 5278 O O . HOH G 6 . ? 19.376 -0.330 4.062 1.00 40.14 ? 2360 HOH A O 1 HETATM 5279 O O . HOH G 6 . ? 19.469 -3.401 1.876 1.00 21.10 ? 2361 HOH A O 1 HETATM 5280 O O . HOH G 6 . ? 38.598 9.498 -7.736 1.00 39.80 ? 2362 HOH A O 1 HETATM 5281 O O . HOH G 6 . ? 40.879 10.478 -11.322 1.00 42.42 ? 2363 HOH A O 1 HETATM 5282 O O . HOH G 6 . ? 14.372 -2.626 5.097 1.00 27.74 ? 2364 HOH A O 1 HETATM 5283 O O . HOH G 6 . ? 9.876 3.208 2.727 1.00 31.38 ? 2365 HOH A O 1 HETATM 5284 O O . HOH G 6 . ? 13.137 5.437 1.150 1.00 21.46 ? 2366 HOH A O 1 HETATM 5285 O O . HOH G 6 . ? 12.003 3.266 -0.325 1.00 20.52 ? 2367 HOH A O 1 HETATM 5286 O O . HOH G 6 . ? 12.938 6.039 3.878 1.00 31.07 ? 2368 HOH A O 1 HETATM 5287 O O . HOH G 6 . ? 8.730 0.710 2.573 1.00 31.95 ? 2369 HOH A O 1 HETATM 5288 O O . HOH G 6 . ? 10.302 -2.963 1.935 1.00 27.29 ? 2370 HOH A O 1 HETATM 5289 O O . HOH G 6 . ? 9.422 -3.894 5.932 1.00 32.90 ? 2371 HOH A O 1 HETATM 5290 O O . HOH G 6 . ? 13.253 -1.894 7.299 1.00 36.86 ? 2372 HOH A O 1 HETATM 5291 O O . HOH G 6 . ? 42.288 14.453 -13.907 1.00 41.17 ? 2373 HOH A O 1 HETATM 5292 O O . HOH G 6 . ? 19.792 3.319 4.296 1.00 44.26 ? 2374 HOH A O 1 HETATM 5293 O O . HOH G 6 . ? 11.693 11.415 -2.425 1.00 42.81 ? 2375 HOH A O 1 HETATM 5294 O O . HOH G 6 . ? 11.761 7.746 0.244 1.00 29.05 ? 2376 HOH A O 1 HETATM 5295 O O . HOH G 6 . ? 38.807 26.359 -13.860 1.00 38.70 ? 2377 HOH A O 1 HETATM 5296 O O . HOH G 6 . ? 39.028 29.943 -16.923 1.00 39.56 ? 2378 HOH A O 1 HETATM 5297 O O . HOH G 6 . ? 15.817 13.859 -0.912 1.00 41.11 ? 2379 HOH A O 1 HETATM 5298 O O . HOH G 6 . ? 22.618 6.186 -0.751 1.00 22.08 ? 2380 HOH A O 1 HETATM 5299 O O . HOH G 6 . ? 22.473 -0.058 0.295 1.00 22.09 ? 2381 HOH A O 1 HETATM 5300 O O . HOH G 6 . ? 22.879 3.371 -0.407 1.00 24.49 ? 2382 HOH A O 1 HETATM 5301 O O . HOH G 6 . ? 17.902 13.539 -5.074 1.00 24.61 ? 2383 HOH A O 1 HETATM 5302 O O . HOH G 6 . ? 14.268 14.484 -5.953 1.00 30.21 ? 2384 HOH A O 1 HETATM 5303 O O . HOH G 6 . ? 23.140 13.229 -1.204 1.00 34.66 ? 2385 HOH A O 1 HETATM 5304 O O . HOH G 6 . ? 22.226 7.448 1.740 1.00 32.49 ? 2386 HOH A O 1 HETATM 5305 O O . HOH G 6 . ? 19.497 9.652 3.931 1.00 40.40 ? 2387 HOH A O 1 HETATM 5306 O O . HOH G 6 . ? 22.875 17.913 -6.154 1.00 33.07 ? 2388 HOH A O 1 HETATM 5307 O O . HOH G 6 . ? 28.630 15.196 -9.326 1.00 27.15 ? 2389 HOH A O 1 HETATM 5308 O O . HOH G 6 . ? 28.407 16.079 -5.398 1.00 29.05 ? 2390 HOH A O 1 HETATM 5309 O O . HOH G 6 . ? 29.269 12.015 -7.370 1.00 39.76 ? 2391 HOH A O 1 HETATM 5310 O O . HOH G 6 . ? 27.053 8.901 -4.314 1.00 37.85 ? 2392 HOH A O 1 HETATM 5311 O O . HOH G 6 . ? 25.247 10.094 -0.315 1.00 42.49 ? 2393 HOH A O 1 HETATM 5312 O O . HOH G 6 . ? 19.164 17.928 -12.809 1.00 25.51 ? 2394 HOH A O 1 HETATM 5313 O O . HOH G 6 . ? 20.486 20.451 -9.427 1.00 41.94 ? 2395 HOH A O 1 HETATM 5314 O O . HOH G 6 . ? 14.625 18.254 -8.384 1.00 48.79 ? 2396 HOH A O 1 HETATM 5315 O O . HOH G 6 . ? 18.907 15.662 -6.488 1.00 30.95 ? 2397 HOH A O 1 HETATM 5316 O O . HOH G 6 . ? 27.201 21.555 -11.639 1.00 27.31 ? 2398 HOH A O 1 HETATM 5317 O O . HOH G 6 . ? 30.510 18.762 -11.466 1.00 40.35 ? 2399 HOH A O 1 HETATM 5318 O O . HOH G 6 . ? 18.825 13.305 -18.811 1.00 19.65 ? 2400 HOH A O 1 HETATM 5319 O O . HOH G 6 . ? 23.234 22.792 -17.337 1.00 18.20 ? 2401 HOH A O 1 HETATM 5320 O O . HOH G 6 . ? 32.198 24.682 -14.226 1.00 32.78 ? 2402 HOH A O 1 HETATM 5321 O O . HOH G 6 . ? 28.790 25.631 -12.503 1.00 35.88 ? 2403 HOH A O 1 HETATM 5322 O O . HOH G 6 . ? 24.777 25.737 -21.698 1.00 21.40 ? 2404 HOH A O 1 HETATM 5323 O O . HOH G 6 . ? 35.107 23.195 -25.644 1.00 40.80 ? 2405 HOH A O 1 HETATM 5324 O O . HOH G 6 . ? 26.733 28.261 -27.726 1.00 30.37 ? 2406 HOH A O 1 HETATM 5325 O O . HOH G 6 . ? 29.333 22.037 -31.651 1.00 20.40 ? 2407 HOH A O 1 HETATM 5326 O O . HOH G 6 . ? 32.166 17.235 -32.310 1.00 30.91 ? 2408 HOH A O 1 HETATM 5327 O O . HOH G 6 . ? 31.704 19.560 -33.843 1.00 31.36 ? 2409 HOH A O 1 HETATM 5328 O O . HOH G 6 . ? 33.391 21.736 -33.361 1.00 36.15 ? 2410 HOH A O 1 HETATM 5329 O O . HOH G 6 . ? 25.271 30.321 -32.198 1.00 48.76 ? 2411 HOH A O 1 HETATM 5330 O O . HOH G 6 . ? 29.529 28.256 -34.033 1.00 48.33 ? 2412 HOH A O 1 HETATM 5331 O O . HOH G 6 . ? 29.144 20.354 -34.730 1.00 27.65 ? 2413 HOH A O 1 HETATM 5332 O O . HOH G 6 . ? 18.877 29.032 -35.028 1.00 39.00 ? 2414 HOH A O 1 HETATM 5333 O O . HOH G 6 . ? 19.762 25.153 -37.390 1.00 35.75 ? 2415 HOH A O 1 HETATM 5334 O O . HOH G 6 . ? 21.263 16.800 -33.309 1.00 24.77 ? 2416 HOH A O 1 HETATM 5335 O O . HOH G 6 . ? 19.727 31.624 -34.506 1.00 39.98 ? 2417 HOH A O 1 HETATM 5336 O O . HOH G 6 . ? 18.964 32.210 -25.818 1.00 45.57 ? 2418 HOH A O 1 HETATM 5337 O O . HOH G 6 . ? 17.293 33.809 -31.168 1.00 44.66 ? 2419 HOH A O 1 HETATM 5338 O O . HOH G 6 . ? 12.899 26.605 -32.451 1.00 34.99 ? 2420 HOH A O 1 HETATM 5339 O O . HOH G 6 . ? 14.145 24.046 -31.647 1.00 24.17 ? 2421 HOH A O 1 HETATM 5340 O O . HOH G 6 . ? 15.227 26.432 -27.886 1.00 36.54 ? 2422 HOH A O 1 HETATM 5341 O O . HOH G 6 . ? 18.361 25.006 -24.931 1.00 26.65 ? 2423 HOH A O 1 HETATM 5342 O O . HOH G 6 . ? 14.509 25.690 -24.820 1.00 29.65 ? 2424 HOH A O 1 HETATM 5343 O O . HOH G 6 . ? 24.155 27.713 -23.499 1.00 36.83 ? 2425 HOH A O 1 HETATM 5344 O O . HOH G 6 . ? 26.405 29.593 -22.430 1.00 37.89 ? 2426 HOH A O 1 HETATM 5345 O O . HOH G 6 . ? 18.893 29.230 -16.826 1.00 37.63 ? 2427 HOH A O 1 HETATM 5346 O O . HOH G 6 . ? 15.077 30.633 -21.022 1.00 35.57 ? 2428 HOH A O 1 HETATM 5347 O O . HOH G 6 . ? 21.846 9.265 -28.532 1.00 24.55 ? 2429 HOH A O 1 HETATM 5348 O O . HOH G 6 . ? 19.452 6.636 -29.818 1.00 36.78 ? 2430 HOH A O 1 HETATM 5349 O O . HOH G 6 . ? 17.012 4.175 -26.456 1.00 27.41 ? 2431 HOH A O 1 HETATM 5350 O O . HOH G 6 . ? 15.670 6.623 -30.511 1.00 17.81 ? 2432 HOH A O 1 HETATM 5351 O O . HOH G 6 . ? 11.949 11.696 -22.115 1.00 18.84 ? 2433 HOH A O 1 HETATM 5352 O O . HOH G 6 . ? 16.741 12.959 -20.650 1.00 21.11 ? 2434 HOH A O 1 HETATM 5353 O O . HOH G 6 . ? 19.869 4.024 -22.813 1.00 33.08 ? 2435 HOH A O 1 HETATM 5354 O O . HOH G 6 . ? 19.692 3.723 -25.766 1.00 40.97 ? 2436 HOH A O 1 HETATM 5355 O O . HOH G 6 . ? 28.333 7.542 -31.015 1.00 39.16 ? 2437 HOH A O 1 HETATM 5356 O O . HOH G 6 . ? 27.924 10.680 -33.552 1.00 30.35 ? 2438 HOH A O 1 HETATM 5357 O O . HOH G 6 . ? 23.868 3.592 -33.867 1.00 34.36 ? 2439 HOH A O 1 HETATM 5358 O O . HOH G 6 . ? 26.947 6.888 -33.470 1.00 42.91 ? 2440 HOH A O 1 HETATM 5359 O O . HOH G 6 . ? 35.860 13.802 -31.874 1.00 35.53 ? 2441 HOH A O 1 HETATM 5360 O O . HOH G 6 . ? 40.001 18.918 -31.318 1.00 27.03 ? 2442 HOH A O 1 HETATM 5361 O O . HOH G 6 . ? 38.448 8.623 -27.904 1.00 28.13 ? 2443 HOH A O 1 HETATM 5362 O O . HOH G 6 . ? 37.344 9.833 -34.637 1.00 53.23 ? 2444 HOH A O 1 HETATM 5363 O O . HOH G 6 . ? 34.723 8.640 -35.306 1.00 49.64 ? 2445 HOH A O 1 HETATM 5364 O O . HOH G 6 . ? 38.416 6.124 -33.565 1.00 33.27 ? 2446 HOH A O 1 HETATM 5365 O O . HOH G 6 . ? 35.705 8.130 -27.991 1.00 24.94 ? 2447 HOH A O 1 HETATM 5366 O O . HOH G 6 . ? 31.111 7.776 -31.169 1.00 36.00 ? 2448 HOH A O 1 HETATM 5367 O O . HOH G 6 . ? 36.289 4.326 -34.311 1.00 24.01 ? 2449 HOH A O 1 HETATM 5368 O O . HOH G 6 . ? 31.467 3.871 -37.550 1.00 25.74 ? 2450 HOH A O 1 HETATM 5369 O O . HOH G 6 . ? 34.666 2.052 -37.354 1.00 24.82 ? 2451 HOH A O 1 HETATM 5370 O O . HOH G 6 . ? 35.332 5.875 -36.412 1.00 38.94 ? 2452 HOH A O 1 HETATM 5371 O O . HOH G 6 . ? 26.422 2.751 -32.668 1.00 23.15 ? 2453 HOH A O 1 HETATM 5372 O O . HOH G 6 . ? 28.937 2.274 -39.790 1.00 36.65 ? 2454 HOH A O 1 HETATM 5373 O O . HOH G 6 . ? 39.368 -3.498 -41.829 1.00 46.85 ? 2455 HOH A O 1 HETATM 5374 O O . HOH G 6 . ? 39.263 2.138 -39.119 1.00 40.30 ? 2456 HOH A O 1 HETATM 5375 O O . HOH G 6 . ? 25.430 -0.452 -39.414 1.00 42.14 ? 2457 HOH A O 1 HETATM 5376 O O . HOH G 6 . ? 24.930 -4.146 -41.728 1.00 37.44 ? 2458 HOH A O 1 HETATM 5377 O O . HOH G 6 . ? 34.236 -5.557 -46.881 1.00 42.25 ? 2459 HOH A O 1 HETATM 5378 O O . HOH G 6 . ? 36.931 -7.550 -35.308 1.00 40.76 ? 2460 HOH A O 1 HETATM 5379 O O . HOH G 6 . ? 27.695 -5.975 -41.768 1.00 26.11 ? 2461 HOH A O 1 HETATM 5380 O O . HOH G 6 . ? 27.698 -14.762 -39.704 1.00 36.53 ? 2462 HOH A O 1 HETATM 5381 O O . HOH G 6 . ? 23.347 -13.286 -38.521 1.00 23.63 ? 2463 HOH A O 1 HETATM 5382 O O . HOH G 6 . ? 36.592 -11.414 -35.875 1.00 46.46 ? 2464 HOH A O 1 HETATM 5383 O O . HOH G 6 . ? 32.071 -17.818 -29.759 1.00 37.57 ? 2465 HOH A O 1 HETATM 5384 O O . HOH G 6 . ? 29.576 -15.910 -37.671 1.00 50.02 ? 2466 HOH A O 1 HETATM 5385 O O . HOH G 6 . ? 32.683 -16.057 -34.382 1.00 46.96 ? 2467 HOH A O 1 HETATM 5386 O O . HOH G 6 . ? 26.586 -19.791 -32.847 1.00 31.37 ? 2468 HOH A O 1 HETATM 5387 O O . HOH G 6 . ? 32.484 -9.686 -26.734 1.00 27.00 ? 2469 HOH A O 1 HETATM 5388 O O . HOH G 6 . ? 27.592 -17.143 -22.677 1.00 19.68 ? 2470 HOH A O 1 HETATM 5389 O O . HOH G 6 . ? 27.565 -21.451 -27.425 1.00 26.72 ? 2471 HOH A O 1 HETATM 5390 O O . HOH G 6 . ? 29.439 -18.740 -29.754 1.00 38.66 ? 2472 HOH A O 1 HETATM 5391 O O . HOH G 6 . ? 34.361 -18.728 -28.444 1.00 40.80 ? 2473 HOH A O 1 HETATM 5392 O O . HOH G 6 . ? 39.125 -18.153 -17.898 1.00 47.10 ? 2474 HOH A O 1 HETATM 5393 O O . HOH G 6 . ? 32.300 -20.254 -13.084 1.00 39.66 ? 2475 HOH A O 1 HETATM 5394 O O . HOH G 6 . ? 36.198 -18.782 -12.344 1.00 30.33 ? 2476 HOH A O 1 HETATM 5395 O O . HOH G 6 . ? 33.316 -21.675 -19.552 1.00 33.04 ? 2477 HOH A O 1 HETATM 5396 O O . HOH G 6 . ? 29.837 -22.450 -16.140 1.00 41.77 ? 2478 HOH A O 1 HETATM 5397 O O . HOH G 6 . ? 25.584 -21.821 -15.320 1.00 32.67 ? 2479 HOH A O 1 HETATM 5398 O O . HOH G 6 . ? 29.974 -23.624 -20.242 1.00 28.36 ? 2480 HOH A O 1 HETATM 5399 O O . HOH G 6 . ? 25.650 -24.273 -21.337 1.00 32.15 ? 2481 HOH A O 1 HETATM 5400 O O . HOH G 6 . ? 20.028 -26.593 -25.157 1.00 37.54 ? 2482 HOH A O 1 HETATM 5401 O O . HOH G 6 . ? 23.554 -27.259 -25.251 1.00 31.96 ? 2483 HOH A O 1 HETATM 5402 O O . HOH G 6 . ? 17.287 -15.033 -36.070 1.00 29.94 ? 2484 HOH A O 1 HETATM 5403 O O . HOH G 6 . ? 14.314 -13.257 -38.048 1.00 34.59 ? 2485 HOH A O 1 HETATM 5404 O O . HOH G 6 . ? 20.061 -9.323 -40.484 1.00 56.08 ? 2486 HOH A O 1 HETATM 5405 O O . HOH G 6 . ? 21.389 -15.239 -37.973 1.00 39.10 ? 2487 HOH A O 1 HETATM 5406 O O . HOH G 6 . ? 17.365 -6.738 -37.626 1.00 27.76 ? 2488 HOH A O 1 HETATM 5407 O O . HOH G 6 . ? 16.136 -8.241 -41.134 1.00 38.83 ? 2489 HOH A O 1 HETATM 5408 O O . HOH G 6 . ? 9.235 -7.453 -41.846 1.00 34.42 ? 2490 HOH A O 1 HETATM 5409 O O . HOH G 6 . ? 11.479 -13.148 -41.883 1.00 45.88 ? 2491 HOH A O 1 HETATM 5410 O O . HOH G 6 . ? 4.286 -14.048 -40.512 1.00 53.56 ? 2492 HOH A O 1 HETATM 5411 O O . HOH G 6 . ? 8.124 -6.326 -39.434 1.00 42.87 ? 2493 HOH A O 1 HETATM 5412 O O . HOH G 6 . ? 8.085 -3.388 -32.357 1.00 36.38 ? 2494 HOH A O 1 HETATM 5413 O O . HOH G 6 . ? 12.342 -8.679 -28.219 1.00 29.50 ? 2495 HOH A O 1 HETATM 5414 O O . HOH G 6 . ? 8.788 -2.726 -29.793 1.00 40.55 ? 2496 HOH A O 1 HETATM 5415 O O . HOH G 6 . ? 15.907 -5.285 -30.797 1.00 23.43 ? 2497 HOH A O 1 HETATM 5416 O O . HOH G 6 . ? 9.154 -3.510 -35.184 1.00 53.60 ? 2498 HOH A O 1 HETATM 5417 O O . HOH G 6 . ? 11.255 -0.968 -29.855 1.00 32.82 ? 2499 HOH A O 1 HETATM 5418 O O . HOH G 6 . ? 10.550 -6.877 -25.414 1.00 41.65 ? 2500 HOH A O 1 HETATM 5419 O O . HOH G 6 . ? 12.069 0.710 -27.689 1.00 21.39 ? 2501 HOH A O 1 HETATM 5420 O O . HOH G 6 . ? 15.667 -2.400 -28.309 1.00 26.74 ? 2502 HOH A O 1 HETATM 5421 O O . HOH G 6 . ? 13.768 -5.324 -21.716 1.00 44.61 ? 2503 HOH A O 1 HETATM 5422 O O . HOH G 6 . ? 14.990 -8.454 -21.323 1.00 32.29 ? 2504 HOH A O 1 HETATM 5423 O O . HOH G 6 . ? 12.040 -14.621 -19.000 1.00 35.18 ? 2505 HOH A O 1 HETATM 5424 O O . HOH G 6 . ? 16.692 -20.198 -14.700 1.00 15.29 ? 2506 HOH A O 1 HETATM 5425 O O . HOH G 6 . ? 16.724 -21.863 -17.618 1.00 27.77 ? 2507 HOH A O 1 HETATM 5426 O O . HOH G 6 . ? 14.465 -16.110 -14.696 1.00 18.51 ? 2508 HOH A O 1 HETATM 5427 O O . HOH G 6 . ? 15.126 -23.182 -19.383 1.00 26.46 ? 2509 HOH A O 1 HETATM 5428 O O . HOH G 6 . ? 9.545 -15.355 -12.237 1.00 52.02 ? 2510 HOH A O 1 HETATM 5429 O O . HOH G 6 . ? 12.959 -14.200 -15.908 1.00 28.97 ? 2511 HOH A O 1 HETATM 5430 O O . HOH G 6 . ? 24.005 -24.558 -19.208 1.00 30.47 ? 2512 HOH A O 1 HETATM 5431 O O . HOH G 6 . ? 20.362 -29.222 -21.601 1.00 42.60 ? 2513 HOH A O 1 HETATM 5432 O O . HOH G 6 . ? 24.427 -26.686 -22.490 1.00 43.11 ? 2514 HOH A O 1 HETATM 5433 O O . HOH G 6 . ? 8.644 -9.219 -26.726 1.00 25.90 ? 2515 HOH A O 1 HETATM 5434 O O . HOH G 6 . ? 20.894 -6.805 -39.279 1.00 36.98 ? 2516 HOH A O 1 HETATM 5435 O O . HOH G 6 . ? 22.497 1.290 -33.483 1.00 28.90 ? 2517 HOH A O 1 HETATM 5436 O O . HOH G 6 . ? 21.478 1.159 -37.360 1.00 35.25 ? 2518 HOH A O 1 HETATM 5437 O O . HOH G 6 . ? 20.792 0.976 -31.353 1.00 48.27 ? 2519 HOH A O 1 HETATM 5438 O O . HOH G 6 . ? 23.045 -4.030 -39.809 1.00 28.11 ? 2520 HOH A O 1 HETATM 5439 O O . HOH G 6 . ? 33.707 3.089 -27.072 1.00 35.81 ? 2521 HOH A O 1 HETATM 5440 O O . HOH G 6 . ? 23.358 -0.086 -26.118 1.00 43.07 ? 2522 HOH A O 1 HETATM 5441 O O . HOH G 6 . ? 17.768 -3.239 -30.111 1.00 33.13 ? 2523 HOH A O 1 HETATM 5442 O O . HOH G 6 . ? 20.846 -0.809 -29.236 1.00 41.07 ? 2524 HOH A O 1 HETATM 5443 O O . HOH G 6 . ? 25.282 -2.897 -22.304 1.00 25.98 ? 2525 HOH A O 1 HETATM 5444 O O . HOH G 6 . ? 22.304 -7.943 -18.085 1.00 19.40 ? 2526 HOH A O 1 HETATM 5445 O O . HOH G 6 . ? 16.694 -6.404 -21.551 1.00 30.37 ? 2527 HOH A O 1 HETATM 5446 O O . HOH G 6 . ? 16.068 -4.518 -20.289 1.00 32.15 ? 2528 HOH A O 1 HETATM 5447 O O . HOH G 6 . ? 25.465 -15.639 -21.395 1.00 20.91 ? 2529 HOH A O 1 HETATM 5448 O O . HOH G 6 . ? 15.002 -10.352 -17.069 1.00 50.61 ? 2530 HOH A O 1 HETATM 5449 O O . HOH G 6 . ? 21.805 -13.275 -7.403 1.00 16.23 ? 2531 HOH A O 1 HETATM 5450 O O . HOH G 6 . ? 23.557 -23.367 -13.024 1.00 34.75 ? 2532 HOH A O 1 HETATM 5451 O O . HOH G 6 . ? 21.906 -23.278 -10.614 1.00 26.44 ? 2533 HOH A O 1 HETATM 5452 O O . HOH G 6 . ? 22.189 -22.210 -8.235 1.00 32.65 ? 2534 HOH A O 1 HETATM 5453 O O . HOH G 6 . ? 25.502 -21.931 -10.969 1.00 25.82 ? 2535 HOH A O 1 HETATM 5454 O O . HOH G 6 . ? 29.741 -20.942 -13.661 1.00 31.12 ? 2536 HOH A O 1 HETATM 5455 O O . HOH G 6 . ? 24.498 -23.995 -16.642 1.00 39.63 ? 2537 HOH A O 1 HETATM 5456 O O . HOH G 6 . ? 18.253 -26.211 -5.359 1.00 44.38 ? 2538 HOH A O 1 HETATM 5457 O O . HOH G 6 . ? 17.909 -28.686 -10.782 1.00 44.91 ? 2539 HOH A O 1 HETATM 5458 O O . HOH G 6 . ? 18.653 -22.217 -2.618 1.00 22.39 ? 2540 HOH A O 1 HETATM 5459 O O . HOH G 6 . ? 21.029 -23.983 -6.407 1.00 46.72 ? 2541 HOH A O 1 HETATM 5460 O O . HOH G 6 . ? 22.563 -20.417 -3.487 1.00 42.83 ? 2542 HOH A O 1 HETATM 5461 O O . HOH G 6 . ? 11.065 -17.318 -10.914 1.00 31.07 ? 2543 HOH A O 1 HETATM 5462 O O . HOH G 6 . ? 10.362 -15.775 -8.790 1.00 38.75 ? 2544 HOH A O 1 HETATM 5463 O O . HOH G 6 . ? 11.293 -14.781 -5.190 1.00 23.75 ? 2545 HOH A O 1 HETATM 5464 O O . HOH G 6 . ? 13.721 -12.491 -13.697 1.00 41.42 ? 2546 HOH A O 1 HETATM 5465 O O . HOH G 6 . ? 11.403 -11.209 -10.328 1.00 36.37 ? 2547 HOH A O 1 HETATM 5466 O O . HOH G 6 . ? 15.360 -9.719 -11.368 1.00 19.67 ? 2548 HOH A O 1 HETATM 5467 O O . HOH G 6 . ? 14.543 -9.346 -8.572 1.00 23.43 ? 2549 HOH A O 1 HETATM 5468 O O . HOH G 6 . ? 20.940 -2.530 -5.135 1.00 17.99 ? 2550 HOH A O 1 HETATM 5469 O O . HOH G 6 . ? 15.358 -6.638 -14.174 1.00 21.25 ? 2551 HOH A O 1 HETATM 5470 O O . HOH G 6 . ? 21.406 -1.879 -17.443 1.00 17.80 ? 2552 HOH A O 1 HETATM 5471 O O . HOH G 6 . ? 13.600 -5.268 -17.936 1.00 33.19 ? 2553 HOH A O 1 HETATM 5472 O O . HOH G 6 . ? 22.555 -0.431 -20.969 1.00 26.62 ? 2554 HOH A O 1 HETATM 5473 O O . HOH G 6 . ? 28.908 0.414 -22.859 1.00 39.93 ? 2555 HOH A O 1 HETATM 5474 O O . HOH G 6 . ? 35.102 1.245 -19.441 1.00 21.85 ? 2556 HOH A O 1 HETATM 5475 O O . HOH G 6 . ? 31.726 3.526 -23.056 1.00 33.84 ? 2557 HOH A O 1 HETATM 5476 O O . HOH G 6 . ? 44.680 -3.753 -26.463 1.00 33.04 ? 2558 HOH A O 1 HETATM 5477 O O . HOH G 6 . ? 43.004 -0.277 -17.060 1.00 26.67 ? 2559 HOH A O 1 HETATM 5478 O O . HOH G 6 . ? 46.035 -4.239 -19.411 1.00 42.80 ? 2560 HOH A O 1 HETATM 5479 O O . HOH G 6 . ? 34.907 -9.159 -27.843 1.00 29.52 ? 2561 HOH A O 1 HETATM 5480 O O . HOH G 6 . ? 43.229 -3.151 -33.772 1.00 40.18 ? 2562 HOH A O 1 HETATM 5481 O O . HOH G 6 . ? 44.579 0.966 -24.848 1.00 42.91 ? 2563 HOH A O 1 HETATM 5482 O O . HOH G 6 . ? 36.849 1.802 -35.527 1.00 29.04 ? 2564 HOH A O 1 HETATM 5483 O O . HOH G 6 . ? 39.505 2.322 -36.390 1.00 29.38 ? 2565 HOH A O 1 HETATM 5484 O O . HOH G 6 . ? 39.859 5.064 -36.732 1.00 43.56 ? 2566 HOH A O 1 HETATM 5485 O O . HOH G 6 . ? 44.403 8.242 -33.009 1.00 39.70 ? 2567 HOH A O 1 HETATM 5486 O O . HOH G 6 . ? 44.619 10.865 -30.340 1.00 43.97 ? 2568 HOH A O 1 HETATM 5487 O O . HOH G 6 . ? 39.612 4.925 -22.267 1.00 36.25 ? 2569 HOH A O 1 HETATM 5488 O O . HOH G 6 . ? 46.228 15.031 -25.756 1.00 42.23 ? 2570 HOH A O 1 HETATM 5489 O O . HOH G 6 . ? 48.312 13.679 -24.106 1.00 41.08 ? 2571 HOH A O 1 HETATM 5490 O O . HOH G 6 . ? 42.751 18.980 -30.877 1.00 41.96 ? 2572 HOH A O 1 HETATM 5491 O O . HOH G 6 . ? 42.452 8.102 -13.786 1.00 35.15 ? 2573 HOH A O 1 HETATM 5492 O O . HOH G 6 . ? 35.060 5.308 -21.090 1.00 39.61 ? 2574 HOH A O 1 HETATM 5493 O O . HOH G 6 . ? 22.609 4.398 -22.106 1.00 26.25 ? 2575 HOH A O 1 HETATM 5494 O O . HOH G 6 . ? 28.870 3.316 -22.705 1.00 33.54 ? 2576 HOH A O 1 HETATM 5495 O O . HOH G 6 . ? 29.022 4.922 -26.721 1.00 36.98 ? 2577 HOH A O 1 HETATM 5496 O O . HOH G 6 . ? 26.880 -0.636 -21.266 1.00 40.80 ? 2578 HOH A O 1 HETATM 5497 O O . HOH G 6 . ? 24.174 2.017 -21.492 1.00 21.39 ? 2579 HOH A O 1 HETATM 5498 O O . HOH G 6 . ? 9.916 1.399 -8.981 1.00 21.87 ? 2580 HOH A O 1 HETATM 5499 O O . HOH G 6 . ? 7.194 10.540 -7.565 1.00 20.64 ? 2581 HOH A O 1 HETATM 5500 O O . HOH G 6 . ? 9.594 10.387 -6.037 1.00 24.71 ? 2582 HOH A O 1 HETATM 5501 O O . HOH G 6 . ? 10.069 13.910 -7.025 1.00 46.53 ? 2583 HOH A O 1 HETATM 5502 O O . HOH G 6 . ? 2.231 11.587 -20.210 1.00 16.70 ? 2584 HOH A O 1 HETATM 5503 O O . HOH G 6 . ? 4.480 13.810 -10.745 1.00 32.04 ? 2585 HOH A O 1 HETATM 5504 O O . HOH G 6 . ? -3.045 10.110 -9.910 1.00 38.93 ? 2586 HOH A O 1 HETATM 5505 O O . HOH G 6 . ? -1.617 6.543 -2.530 1.00 30.36 ? 2587 HOH A O 1 HETATM 5506 O O . HOH G 6 . ? 4.633 8.496 -0.634 1.00 47.08 ? 2588 HOH A O 1 HETATM 5507 O O . HOH G 6 . ? 9.156 6.416 -3.063 1.00 38.59 ? 2589 HOH A O 1 HETATM 5508 O O . HOH G 6 . ? 5.429 9.951 -5.502 1.00 25.67 ? 2590 HOH A O 1 HETATM 5509 O O . HOH G 6 . ? 9.025 8.981 -3.799 1.00 37.66 ? 2591 HOH A O 1 HETATM 5510 O O . HOH G 6 . ? 7.569 3.213 -0.696 1.00 27.59 ? 2592 HOH A O 1 HETATM 5511 O O . HOH G 6 . ? 1.022 16.597 -7.990 1.00 48.35 ? 2593 HOH A O 1 HETATM 5512 O O . HOH G 6 . ? 4.002 13.782 -6.639 1.00 38.09 ? 2594 HOH A O 1 HETATM 5513 O O . HOH G 6 . ? 0.563 10.236 -1.867 1.00 30.53 ? 2595 HOH A O 1 HETATM 5514 O O . HOH G 6 . ? 4.824 10.681 -2.172 1.00 37.84 ? 2596 HOH A O 1 HETATM 5515 O O . HOH G 6 . ? -3.036 17.563 -10.171 1.00 32.20 ? 2597 HOH A O 1 HETATM 5516 O O . HOH G 6 . ? -7.657 12.012 -11.326 1.00 37.51 ? 2598 HOH A O 1 HETATM 5517 O O . HOH G 6 . ? -10.093 15.285 -14.952 1.00 53.98 ? 2599 HOH A O 1 HETATM 5518 O O . HOH G 6 . ? -7.193 18.459 -18.876 1.00 34.22 ? 2600 HOH A O 1 HETATM 5519 O O . HOH G 6 . ? -1.975 20.413 -16.654 1.00 24.04 ? 2601 HOH A O 1 HETATM 5520 O O . HOH G 6 . ? 4.577 20.718 -17.866 1.00 39.79 ? 2602 HOH A O 1 HETATM 5521 O O . HOH G 6 . ? 5.150 16.208 -12.172 1.00 22.36 ? 2603 HOH A O 1 HETATM 5522 O O . HOH G 6 . ? 10.109 18.858 -20.412 1.00 15.95 ? 2604 HOH A O 1 HETATM 5523 O O . HOH G 6 . ? 8.950 20.114 -11.401 1.00 44.96 ? 2605 HOH A O 1 HETATM 5524 O O . HOH G 6 . ? 1.073 18.815 -12.841 1.00 47.16 ? 2606 HOH A O 1 HETATM 5525 O O . HOH G 6 . ? 12.811 23.464 -14.287 1.00 34.81 ? 2607 HOH A O 1 HETATM 5526 O O . HOH G 6 . ? 8.306 22.405 -16.705 1.00 22.62 ? 2608 HOH A O 1 HETATM 5527 O O . HOH G 6 . ? 15.823 21.688 -11.771 1.00 40.80 ? 2609 HOH A O 1 HETATM 5528 O O . HOH G 6 . ? 9.744 16.459 -8.120 1.00 48.16 ? 2610 HOH A O 1 HETATM 5529 O O . HOH G 6 . ? 6.828 17.715 -10.662 1.00 32.10 ? 2611 HOH A O 1 HETATM 5530 O O . HOH G 6 . ? 11.151 26.468 -22.923 1.00 19.77 ? 2612 HOH A O 1 HETATM 5531 O O . HOH G 6 . ? 12.219 22.632 -27.544 1.00 17.81 ? 2613 HOH A O 1 HETATM 5532 O O . HOH G 6 . ? 10.715 22.543 -33.902 1.00 36.41 ? 2614 HOH A O 1 HETATM 5533 O O . HOH G 6 . ? 9.144 24.194 -32.233 1.00 29.89 ? 2615 HOH A O 1 HETATM 5534 O O . HOH G 6 . ? 12.078 23.671 -30.043 1.00 24.16 ? 2616 HOH A O 1 HETATM 5535 O O . HOH G 6 . ? 0.081 21.597 -28.583 1.00 26.95 ? 2617 HOH A O 1 HETATM 5536 O O . HOH G 6 . ? -0.363 17.930 -30.440 1.00 23.54 ? 2618 HOH A O 1 HETATM 5537 O O . HOH G 6 . ? -1.710 19.592 -27.758 1.00 22.37 ? 2619 HOH A O 1 HETATM 5538 O O . HOH G 6 . ? -5.331 21.942 -25.548 1.00 43.50 ? 2620 HOH A O 1 HETATM 5539 O O . HOH G 6 . ? -4.188 21.419 -22.088 1.00 31.55 ? 2621 HOH A O 1 HETATM 5540 O O . HOH G 6 . ? -7.152 15.842 -20.331 1.00 40.68 ? 2622 HOH A O 1 HETATM 5541 O O . HOH G 6 . ? -3.671 16.442 -29.410 1.00 24.28 ? 2623 HOH A O 1 HETATM 5542 O O . HOH G 6 . ? -6.579 13.929 -27.088 1.00 38.41 ? 2624 HOH A O 1 HETATM 5543 O O . HOH G 6 . ? 7.520 8.979 -23.278 1.00 14.28 ? 2625 HOH A O 1 HETATM 5544 O O . HOH G 6 . ? 11.407 2.848 -25.878 1.00 15.99 ? 2626 HOH A O 1 HETATM 5545 O O . HOH G 6 . ? 15.023 2.238 -25.644 1.00 22.81 ? 2627 HOH A O 1 HETATM 5546 O O . HOH G 6 . ? 8.562 -6.338 -21.961 1.00 39.00 ? 2628 HOH A O 1 HETATM 5547 O O . HOH G 6 . ? 5.863 -6.303 -20.613 1.00 27.60 ? 2629 HOH A O 1 HETATM 5548 O O . HOH G 6 . ? 5.743 -6.461 -16.746 1.00 47.56 ? 2630 HOH A O 1 HETATM 5549 O O . HOH G 6 . ? 7.419 -4.444 -14.088 1.00 20.77 ? 2631 HOH A O 1 HETATM 5550 O O . HOH G 6 . ? 2.710 -6.480 -16.495 1.00 24.24 ? 2632 HOH A O 1 HETATM 5551 O O . HOH G 6 . ? 10.795 -7.845 -16.062 1.00 45.52 ? 2633 HOH A O 1 HETATM 5552 O O . HOH G 6 . ? 10.347 -5.002 -10.842 1.00 22.23 ? 2634 HOH A O 1 HETATM 5553 O O . HOH G 6 . ? 10.989 -7.714 -11.131 1.00 34.05 ? 2635 HOH A O 1 HETATM 5554 O O . HOH G 6 . ? 28.553 3.402 -8.457 1.00 18.85 ? 2636 HOH A O 1 HETATM 5555 O O . HOH G 6 . ? 33.356 -1.676 -6.262 1.00 25.38 ? 2637 HOH A O 1 HETATM 5556 O O . HOH G 6 . ? 34.158 1.825 -4.302 1.00 33.82 ? 2638 HOH A O 1 HETATM 5557 O O . HOH G 6 . ? 39.916 2.933 -5.653 1.00 42.37 ? 2639 HOH A O 1 HETATM 5558 O O . HOH G 6 . ? 38.059 -6.069 -5.791 1.00 42.22 ? 2640 HOH A O 1 HETATM 5559 O O . HOH G 6 . ? 36.177 -4.551 -4.751 1.00 27.40 ? 2641 HOH A O 1 HETATM 5560 O O . HOH G 6 . ? 42.479 -11.849 -8.453 1.00 33.29 ? 2642 HOH A O 1 HETATM 5561 O O . HOH G 6 . ? 39.061 -8.378 -4.694 1.00 37.39 ? 2643 HOH A O 1 HETATM 5562 O O . HOH G 6 . ? 40.823 6.232 -10.351 1.00 30.96 ? 2644 HOH A O 1 HETATM 5563 O O . HOH G 6 . ? 44.500 4.604 -12.366 1.00 39.38 ? 2645 HOH A O 1 HETATM 5564 O O . HOH G 6 . ? 49.398 -1.517 -10.414 1.00 38.21 ? 2646 HOH A O 1 HETATM 5565 O O . HOH G 6 . ? 51.163 6.001 -11.947 1.00 47.44 ? 2647 HOH A O 1 HETATM 5566 O O . HOH G 6 . ? 45.690 7.030 -16.494 1.00 44.81 ? 2648 HOH A O 1 HETATM 5567 O O . HOH G 6 . ? 45.439 1.953 -20.385 1.00 41.77 ? 2649 HOH A O 1 HETATM 5568 O O . HOH G 6 . ? 40.783 5.658 -13.213 1.00 33.26 ? 2650 HOH A O 1 HETATM 5569 O O . HOH G 6 . ? 38.503 6.635 -14.665 1.00 26.73 ? 2651 HOH A O 1 HETATM 5570 O O . HOH G 6 . ? 41.243 -9.358 -17.875 1.00 34.54 ? 2652 HOH A O 1 HETATM 5571 O O . HOH G 6 . ? 42.404 -7.293 -23.118 1.00 31.92 ? 2653 HOH A O 1 HETATM 5572 O O . HOH G 6 . ? 42.148 -16.006 -15.692 1.00 29.93 ? 2654 HOH A O 1 HETATM 5573 O O . HOH G 6 . ? 42.236 -12.551 -13.556 1.00 37.40 ? 2655 HOH A O 1 HETATM 5574 O O . HOH G 6 . ? 37.418 -14.038 -7.663 1.00 31.47 ? 2656 HOH A O 1 HETATM 5575 O O . HOH G 6 . ? 27.416 -18.129 -3.698 1.00 29.09 ? 2657 HOH A O 1 HETATM 5576 O O . HOH G 6 . ? 33.805 -13.176 -4.922 1.00 27.94 ? 2658 HOH A O 1 HETATM 5577 O O . HOH G 6 . ? 35.332 -17.534 -5.528 1.00 42.42 ? 2659 HOH A O 1 HETATM 5578 O O . HOH G 6 . ? 25.088 -20.087 -4.858 1.00 42.77 ? 2660 HOH A O 1 HETATM 5579 O O . HOH G 6 . ? 20.254 -13.823 -3.521 1.00 18.15 ? 2661 HOH A O 1 HETATM 5580 O O . HOH G 6 . ? 21.697 -18.893 -1.310 1.00 25.03 ? 2662 HOH A O 1 HETATM 5581 O O . HOH G 6 . ? 18.756 -19.081 5.552 1.00 41.51 ? 2663 HOH A O 1 HETATM 5582 O O . HOH G 6 . ? 20.580 -12.932 4.826 1.00 35.35 ? 2664 HOH A O 1 HETATM 5583 O O . HOH G 6 . ? 20.777 -9.444 4.021 1.00 25.24 ? 2665 HOH A O 1 HETATM 5584 O O . HOH G 6 . ? 23.483 -11.784 5.893 1.00 31.82 ? 2666 HOH A O 1 HETATM 5585 O O . HOH G 6 . ? 26.836 -10.956 6.078 1.00 23.99 ? 2667 HOH A O 1 HETATM 5586 O O . HOH G 6 . ? 35.524 -5.051 -2.220 1.00 27.25 ? 2668 HOH A O 1 HETATM 5587 O O . HOH G 6 . ? 31.979 0.080 -4.953 1.00 40.42 ? 2669 HOH A O 1 HETATM 5588 O O . HOH G 6 . ? 29.522 -0.297 -0.790 1.00 30.68 ? 2670 HOH A O 1 HETATM 5589 O O . HOH G 6 . ? 22.199 -2.534 1.902 1.00 21.79 ? 2671 HOH A O 1 HETATM 5590 O O . HOH G 6 . ? 24.404 -4.480 5.960 1.00 35.81 ? 2672 HOH A O 1 HETATM 5591 O O . HOH G 6 . ? 21.038 -5.865 5.104 1.00 40.82 ? 2673 HOH A O 1 HETATM 5592 O O . HOH G 6 . ? 30.520 2.556 -5.275 1.00 32.87 ? 2674 HOH A O 1 HETATM 5593 O O . HOH G 6 . ? 27.213 6.752 -2.528 1.00 28.62 ? 2675 HOH A O 1 HETATM 5594 O O . HOH G 6 . ? 28.581 9.604 -6.492 1.00 33.94 ? 2676 HOH A O 1 HETATM 5595 O O . HOH G 6 . ? 34.245 8.271 -5.802 1.00 32.38 ? 2677 HOH A O 1 HETATM 5596 O O . HOH G 6 . ? 36.197 6.293 -4.671 1.00 42.78 ? 2678 HOH A O 1 HETATM 5597 O O . HOH G 6 . ? 33.193 12.293 -10.682 1.00 27.66 ? 2679 HOH A O 1 HETATM 5598 O O . HOH G 6 . ? 35.733 10.250 -7.262 1.00 38.60 ? 2680 HOH A O 1 HETATM 5599 O O . HOH G 6 . ? 39.183 8.422 -10.370 1.00 30.29 ? 2681 HOH A O 1 HETATM 5600 O O . HOH G 6 . ? 40.804 13.282 -11.845 1.00 39.64 ? 2682 HOH A O 1 HETATM 5601 O O . HOH G 6 . ? 41.039 15.677 -16.128 1.00 33.75 ? 2683 HOH A O 1 HETATM 5602 O O . HOH G 6 . ? 38.410 21.776 -12.920 1.00 32.85 ? 2684 HOH A O 1 HETATM 5603 O O . HOH G 6 . ? 39.244 21.868 -19.461 1.00 35.57 ? 2685 HOH A O 1 HETATM 5604 O O . HOH G 6 . ? 35.209 24.163 -10.608 1.00 40.61 ? 2686 HOH A O 1 HETATM 5605 O O . HOH G 6 . ? 37.264 24.255 -12.672 1.00 39.23 ? 2687 HOH A O 1 HETATM 5606 O O . HOH G 6 . ? 38.889 27.124 -16.736 1.00 40.38 ? 2688 HOH A O 1 HETATM 5607 O O . HOH G 6 . ? 30.450 27.644 -16.711 1.00 43.68 ? 2689 HOH A O 1 HETATM 5608 O O . HOH G 6 . ? 29.064 30.447 -23.706 1.00 44.95 ? 2690 HOH A O 1 HETATM 5609 O O . HOH G 6 . ? 32.310 31.343 -25.140 1.00 47.46 ? 2691 HOH A O 1 HETATM 5610 O O . HOH G 6 . ? 25.978 29.360 -15.256 1.00 35.70 ? 2692 HOH A O 1 HETATM 5611 O O . HOH G 6 . ? 18.494 24.704 -13.326 1.00 31.85 ? 2693 HOH A O 1 HETATM 5612 O O . HOH G 6 . ? 12.290 28.242 -20.815 1.00 34.19 ? 2694 HOH A O 1 HETATM 5613 O O . HOH G 6 . ? 12.429 29.436 -14.700 1.00 38.01 ? 2695 HOH A O 1 HETATM 5614 O O . HOH G 6 . ? 5.542 24.087 -19.729 1.00 21.71 ? 2696 HOH A O 1 HETATM 5615 O O . HOH G 6 . ? 8.202 20.821 -21.133 1.00 16.93 ? 2697 HOH A O 1 HETATM 5616 O O . HOH G 6 . ? 11.294 28.579 -26.845 1.00 40.47 ? 2698 HOH A O 1 HETATM 5617 O O . HOH G 6 . ? 11.898 26.391 -28.788 1.00 32.35 ? 2699 HOH A O 1 HETATM 5618 O O . HOH G 6 . ? 1.837 23.388 -17.774 1.00 35.11 ? 2700 HOH A O 1 HETATM 5619 O O . HOH G 6 . ? 0.358 26.259 -18.898 1.00 28.59 ? 2701 HOH A O 1 HETATM 5620 O O . HOH G 6 . ? -6.656 23.926 -17.603 1.00 45.63 ? 2702 HOH A O 1 HETATM 5621 O O . HOH G 6 . ? 35.214 -25.528 -8.847 1.00 51.11 ? 2703 HOH A O 1 HETATM 5622 O O . HOH G 6 . ? 33.973 -28.112 -11.168 1.00 52.91 ? 2704 HOH A O 1 HETATM 5623 O O . HOH G 6 . ? -3.661 -15.674 -36.805 1.00 46.65 ? 2705 HOH A O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 LEU 1 18 18 LEU LEU A . n A 1 2 VAL 2 19 19 VAL VAL A . n A 1 3 LYS 3 20 20 LYS LYS A . n A 1 4 GLU 4 21 21 GLU GLU A . n A 1 5 GLU 5 22 22 GLU GLU A . n A 1 6 ILE 6 23 23 ILE ILE A . n A 1 7 GLN 7 24 24 GLN GLN A . n A 1 8 ALA 8 25 25 ALA ALA A . n A 1 9 LYS 9 26 26 LYS LYS A . n A 1 10 GLU 10 27 27 GLU GLU A . n A 1 11 TYR 11 28 28 TYR TYR A . n A 1 12 LEU 12 29 29 LEU LEU A . n A 1 13 GLU 13 30 30 GLU GLU A . n A 1 14 ASN 14 31 31 ASN ASN A . n A 1 15 LEU 15 32 32 LEU LEU A . n A 1 16 ASN 16 33 33 ASN ASN A . n A 1 17 LYS 17 34 34 LYS LYS A . n A 1 18 GLU 18 35 35 GLU GLU A . n A 1 19 LEU 19 36 36 LEU LEU A . n A 1 20 ALA 20 37 37 ALA ALA A . n A 1 21 LYS 21 38 38 LYS LYS A . n A 1 22 ARG 22 39 39 ARG ARG A . n A 1 23 THR 23 40 40 THR THR A . n A 1 24 ASN 24 41 41 ASN ASN A . n A 1 25 VAL 25 42 42 VAL VAL A . n A 1 26 GLU 26 43 43 GLU GLU A . n A 1 27 THR 27 44 44 THR THR A . n A 1 28 GLU 28 45 45 GLU GLU A . n A 1 29 ALA 29 46 46 ALA ALA A . n A 1 30 ALA 30 47 47 ALA ALA A . n A 1 31 TRP 31 48 48 TRP TRP A . n A 1 32 ALA 32 49 49 ALA ALA A . n A 1 33 TYR 33 50 50 TYR TYR A . n A 1 34 GLY 34 51 51 GLY GLY A . n A 1 35 SER 35 52 52 SER SER A . n A 1 36 ASN 36 53 53 ASN ASN A . n A 1 37 ILE 37 54 54 ILE ILE A . n A 1 38 THR 38 55 55 THR THR A . n A 1 39 ASP 39 56 56 ASP ASP A . n A 1 40 GLU 40 57 57 GLU GLU A . n A 1 41 ASN 41 58 58 ASN ASN A . n A 1 42 GLU 42 59 59 GLU GLU A . n A 1 43 LYS 43 60 60 LYS LYS A . n A 1 44 LYS 44 61 61 LYS LYS A . n A 1 45 LYS 45 62 62 LYS LYS A . n A 1 46 ASN 46 63 63 ASN ASN A . n A 1 47 GLU 47 64 64 GLU GLU A . n A 1 48 ILE 48 65 65 ILE ILE A . n A 1 49 SER 49 66 66 SER SER A . n A 1 50 ALA 50 67 67 ALA ALA A . n A 1 51 GLU 51 68 68 GLU GLU A . n A 1 52 LEU 52 69 69 LEU LEU A . n A 1 53 ALA 53 70 70 ALA ALA A . n A 1 54 LYS 54 71 71 LYS LYS A . n A 1 55 PHE 55 72 72 PHE PHE A . n A 1 56 MET 56 73 73 MET MET A . n A 1 57 LYS 57 74 74 LYS LYS A . n A 1 58 GLU 58 75 75 GLU GLU A . n A 1 59 VAL 59 76 76 VAL VAL A . n A 1 60 ALA 60 77 77 ALA ALA A . n A 1 61 SER 61 78 78 SER SER A . n A 1 62 ASP 62 79 79 ASP ASP A . n A 1 63 THR 63 80 80 THR THR A . n A 1 64 THR 64 81 81 THR THR A . n A 1 65 LYS 65 82 82 LYS LYS A . n A 1 66 PHE 66 83 83 PHE PHE A . n A 1 67 GLN 67 84 84 GLN GLN A . n A 1 68 TRP 68 85 85 TRP TRP A . n A 1 69 ARG 69 86 86 ARG ARG A . n A 1 70 SER 70 87 87 SER SER A . n A 1 71 TYR 71 88 88 TYR TYR A . n A 1 72 GLN 72 89 89 GLN GLN A . n A 1 73 SER 73 90 90 SER SER A . n A 1 74 GLU 74 91 91 GLU GLU A . n A 1 75 ASP 75 92 92 ASP ASP A . n A 1 76 LEU 76 93 93 LEU LEU A . n A 1 77 LYS 77 94 94 LYS LYS A . n A 1 78 ARG 78 95 95 ARG ARG A . n A 1 79 GLN 79 96 96 GLN GLN A . n A 1 80 PHE 80 97 97 PHE PHE A . n A 1 81 LYS 81 98 98 LYS LYS A . n A 1 82 ALA 82 99 99 ALA ALA A . n A 1 83 LEU 83 100 100 LEU LEU A . n A 1 84 THR 84 101 101 THR THR A . n A 1 85 LYS 85 102 102 LYS LYS A . n A 1 86 LEU 86 103 103 LEU LEU A . n A 1 87 GLY 87 104 104 GLY GLY A . n A 1 88 TYR 88 105 105 TYR TYR A . n A 1 89 ALA 89 106 106 ALA ALA A . n A 1 90 ALA 90 107 107 ALA ALA A . n A 1 91 LEU 91 108 108 LEU LEU A . n A 1 92 PRO 92 109 109 PRO PRO A . n A 1 93 GLU 93 110 110 GLU GLU A . n A 1 94 ASP 94 111 111 ASP ASP A . n A 1 95 ASP 95 112 112 ASP ASP A . n A 1 96 TYR 96 113 113 TYR TYR A . n A 1 97 ALA 97 114 114 ALA ALA A . n A 1 98 GLU 98 115 115 GLU GLU A . n A 1 99 LEU 99 116 116 LEU LEU A . n A 1 100 LEU 100 117 117 LEU LEU A . n A 1 101 ASP 101 118 118 ASP ASP A . n A 1 102 THR 102 119 119 THR THR A . n A 1 103 LEU 103 120 120 LEU LEU A . n A 1 104 SER 104 121 121 SER SER A . n A 1 105 ALA 105 122 122 ALA ALA A . n A 1 106 MET 106 123 123 MET MET A . n A 1 107 GLU 107 124 124 GLU GLU A . n A 1 108 SER 108 125 125 SER SER A . n A 1 109 ASN 109 126 126 ASN ASN A . n A 1 110 PHE 110 127 127 PHE PHE A . n A 1 111 ALA 111 128 128 ALA ALA A . n A 1 112 LYS 112 129 129 LYS LYS A . n A 1 113 VAL 113 130 130 VAL VAL A . n A 1 114 LYS 114 131 131 LYS LYS A . n A 1 115 VAL 115 132 132 VAL VAL A . n A 1 116 CYS 116 133 133 CYS CYS A . n A 1 117 ASP 117 134 134 ASP ASP A . n A 1 118 TYR 118 135 135 TYR TYR A . n A 1 119 LYS 119 136 136 LYS LYS A . n A 1 120 ASP 120 137 137 ASP ASP A . n A 1 121 SER 121 138 138 SER SER A . n A 1 122 THR 122 139 139 THR THR A . n A 1 123 LYS 123 140 140 LYS LYS A . n A 1 124 CYS 124 141 141 CYS CYS A . n A 1 125 ASP 125 142 142 ASP ASP A . n A 1 126 LEU 126 143 143 LEU LEU A . n A 1 127 ALA 127 144 144 ALA ALA A . n A 1 128 LEU 128 145 145 LEU LEU A . n A 1 129 ASP 129 146 146 ASP ASP A . n A 1 130 PRO 130 147 147 PRO PRO A . n A 1 131 GLU 131 148 148 GLU GLU A . n A 1 132 ILE 132 149 149 ILE ILE A . n A 1 133 GLU 133 150 150 GLU GLU A . n A 1 134 GLU 134 151 151 GLU GLU A . n A 1 135 VAL 135 152 152 VAL VAL A . n A 1 136 ILE 136 153 153 ILE ILE A . n A 1 137 SER 137 154 154 SER SER A . n A 1 138 LYS 138 155 155 LYS LYS A . n A 1 139 SER 139 156 156 SER SER A . n A 1 140 ARG 140 157 157 ARG ARG A . n A 1 141 ASP 141 158 158 ASP ASP A . n A 1 142 HIS 142 159 159 HIS HIS A . n A 1 143 GLU 143 160 160 GLU GLU A . n A 1 144 GLU 144 161 161 GLU GLU A . n A 1 145 LEU 145 162 162 LEU LEU A . n A 1 146 ALA 146 163 163 ALA ALA A . n A 1 147 TYR 147 164 164 TYR TYR A . n A 1 148 TYR 148 165 165 TYR TYR A . n A 1 149 TRP 149 166 166 TRP TRP A . n A 1 150 ARG 150 167 167 ARG ARG A . n A 1 151 GLU 151 168 168 GLU GLU A . n A 1 152 PHE 152 169 169 PHE PHE A . n A 1 153 TYR 153 170 170 TYR TYR A . n A 1 154 ASP 154 171 171 ASP ASP A . n A 1 155 LYS 155 172 172 LYS LYS A . n A 1 156 ALA 156 173 173 ALA ALA A . n A 1 157 GLY 157 174 174 GLY GLY A . n A 1 158 THR 158 175 175 THR THR A . n A 1 159 ALA 159 176 176 ALA ALA A . n A 1 160 VAL 160 177 177 VAL VAL A . n A 1 161 ARG 161 178 178 ARG ARG A . n A 1 162 SER 162 179 179 SER SER A . n A 1 163 GLN 163 180 180 GLN GLN A . n A 1 164 PHE 164 181 181 PHE PHE A . n A 1 165 GLU 165 182 182 GLU GLU A . n A 1 166 ARG 166 183 183 ARG ARG A . n A 1 167 TYR 167 184 184 TYR TYR A . n A 1 168 VAL 168 185 185 VAL VAL A . n A 1 169 GLU 169 186 186 GLU GLU A . n A 1 170 LEU 170 187 187 LEU LEU A . n A 1 171 ASN 171 188 188 ASN ASN A . n A 1 172 THR 172 189 189 THR THR A . n A 1 173 LYS 173 190 190 LYS LYS A . n A 1 174 ALA 174 191 191 ALA ALA A . n A 1 175 ALA 175 192 192 ALA ALA A . n A 1 176 LYS 176 193 193 LYS LYS A . n A 1 177 LEU 177 194 194 LEU LEU A . n A 1 178 ASN 178 195 195 ASN ASN A . n A 1 179 ASN 179 196 196 ASN ASN A . n A 1 180 PHE 180 197 197 PHE PHE A . n A 1 181 THR 181 198 198 THR THR A . n A 1 182 SER 182 199 199 SER SER A . n A 1 183 GLY 183 200 200 GLY GLY A . n A 1 184 ALA 184 201 201 ALA ALA A . n A 1 185 GLU 185 202 202 GLU GLU A . n A 1 186 ALA 186 203 203 ALA ALA A . n A 1 187 TRP 187 204 204 TRP TRP A . n A 1 188 LEU 188 205 205 LEU LEU A . n A 1 189 ASP 189 206 206 ASP ASP A . n A 1 190 GLU 190 207 207 GLU GLU A . n A 1 191 TYR 191 208 208 TYR TYR A . n A 1 192 GLU 192 209 209 GLU GLU A . n A 1 193 ASP 193 210 210 ASP ASP A . n A 1 194 ASP 194 211 211 ASP ASP A . n A 1 195 THR 195 212 212 THR THR A . n A 1 196 PHE 196 213 213 PHE PHE A . n A 1 197 GLU 197 214 214 GLU GLU A . n A 1 198 GLN 198 215 215 GLN GLN A . n A 1 199 GLN 199 216 216 GLN GLN A . n A 1 200 LEU 200 217 217 LEU LEU A . n A 1 201 GLU 201 218 218 GLU GLU A . n A 1 202 ASP 202 219 219 ASP ASP A . n A 1 203 ILE 203 220 220 ILE ILE A . n A 1 204 PHE 204 221 221 PHE PHE A . n A 1 205 ALA 205 222 222 ALA ALA A . n A 1 206 ASP 206 223 223 ASP ASP A . n A 1 207 ILE 207 224 224 ILE ILE A . n A 1 208 ARG 208 225 225 ARG ARG A . n A 1 209 PRO 209 226 226 PRO PRO A . n A 1 210 LEU 210 227 227 LEU LEU A . n A 1 211 TYR 211 228 228 TYR TYR A . n A 1 212 GLN 212 229 229 GLN GLN A . n A 1 213 GLN 213 230 230 GLN GLN A . n A 1 214 ILE 214 231 231 ILE ILE A . n A 1 215 HIS 215 232 232 HIS HIS A . n A 1 216 GLY 216 233 233 GLY GLY A . n A 1 217 TYR 217 234 234 TYR TYR A . n A 1 218 VAL 218 235 235 VAL VAL A . n A 1 219 ARG 219 236 236 ARG ARG A . n A 1 220 PHE 220 237 237 PHE PHE A . n A 1 221 ARG 221 238 238 ARG ARG A . n A 1 222 LEU 222 239 239 LEU LEU A . n A 1 223 ARG 223 240 240 ARG ARG A . n A 1 224 LYS 224 241 241 LYS LYS A . n A 1 225 HIS 225 242 242 HIS HIS A . n A 1 226 TYR 226 243 243 TYR TYR A . n A 1 227 GLY 227 244 244 GLY GLY A . n A 1 228 ASP 228 245 245 ASP ASP A . n A 1 229 ALA 229 246 246 ALA ALA A . n A 1 230 VAL 230 247 247 VAL VAL A . n A 1 231 VAL 231 248 248 VAL VAL A . n A 1 232 SER 232 249 249 SER SER A . n A 1 233 GLU 233 250 250 GLU GLU A . n A 1 234 THR 234 251 251 THR THR A . n A 1 235 GLY 235 252 252 GLY GLY A . n A 1 236 PRO 236 253 253 PRO PRO A . n A 1 237 ILE 237 254 254 ILE ILE A . n A 1 238 PRO 238 255 255 PRO PRO A . n A 1 239 MET 239 256 256 MET MET A . n A 1 240 HIS 240 257 257 HIS HIS A . n A 1 241 LEU 241 258 258 LEU LEU A . n A 1 242 LEU 242 259 259 LEU LEU A . n A 1 243 GLY 243 260 260 GLY GLY A . n A 1 244 ASN 244 261 261 ASN ASN A . n A 1 245 MET 245 262 262 MET MET A . n A 1 246 TRP 246 263 263 TRP TRP A . n A 1 247 ALA 247 264 264 ALA ALA A . n A 1 248 GLN 248 265 265 GLN GLN A . n A 1 249 GLN 249 266 266 GLN GLN A . n A 1 250 TRP 250 267 267 TRP TRP A . n A 1 251 SER 251 268 268 SER SER A . n A 1 252 GLU 252 269 269 GLU GLU A . n A 1 253 ILE 253 270 270 ILE ILE A . n A 1 254 ALA 254 271 271 ALA ALA A . n A 1 255 ASP 255 272 272 ASP ASP A . n A 1 256 ILE 256 273 273 ILE ILE A . n A 1 257 VAL 257 274 274 VAL VAL A . n A 1 258 SER 258 275 275 SER SER A . n A 1 259 PRO 259 276 276 PRO PRO A . n A 1 260 PHE 260 277 277 PHE PHE A . n A 1 261 PRO 261 278 278 PRO PRO A . n A 1 262 GLU 262 279 279 GLU GLU A . n A 1 263 LYS 263 280 280 LYS LYS A . n A 1 264 PRO 264 281 281 PRO PRO A . n A 1 265 LEU 265 282 282 LEU LEU A . n A 1 266 VAL 266 283 283 VAL VAL A . n A 1 267 ASP 267 284 284 ASP ASP A . n A 1 268 VAL 268 285 285 VAL VAL A . n A 1 269 SER 269 286 286 SER SER A . n A 1 270 ALA 270 287 287 ALA ALA A . n A 1 271 GLU 271 288 288 GLU GLU A . n A 1 272 MET 272 289 289 MET MET A . n A 1 273 GLU 273 290 290 GLU GLU A . n A 1 274 LYS 274 291 291 LYS LYS A . n A 1 275 GLN 275 292 292 GLN GLN A . n A 1 276 GLY 276 293 293 GLY GLY A . n A 1 277 TYR 277 294 294 TYR TYR A . n A 1 278 THR 278 295 295 THR THR A . n A 1 279 PRO 279 296 296 PRO PRO A . n A 1 280 LEU 280 297 297 LEU LEU A . n A 1 281 LYS 281 298 298 LYS LYS A . n A 1 282 MET 282 299 299 MET MET A . n A 1 283 PHE 283 300 300 PHE PHE A . n A 1 284 GLN 284 301 301 GLN GLN A . n A 1 285 MET 285 302 302 MET MET A . n A 1 286 GLY 286 303 303 GLY GLY A . n A 1 287 ASP 287 304 304 ASP ASP A . n A 1 288 ASP 288 305 305 ASP ASP A . n A 1 289 PHE 289 306 306 PHE PHE A . n A 1 290 PHE 290 307 307 PHE PHE A . n A 1 291 THR 291 308 308 THR THR A . n A 1 292 SER 292 309 309 SER SER A . n A 1 293 MET 293 310 310 MET MET A . n A 1 294 ASN 294 311 311 ASN ASN A . n A 1 295 LEU 295 312 312 LEU LEU A . n A 1 296 THR 296 313 313 THR THR A . n A 1 297 LYS 297 314 314 LYS LYS A . n A 1 298 LEU 298 315 315 LEU LEU A . n A 1 299 PRO 299 316 316 PRO PRO A . n A 1 300 GLN 300 317 317 GLN GLN A . n A 1 301 ASP 301 318 318 ASP ASP A . n A 1 302 PHE 302 319 319 PHE PHE A . n A 1 303 TRP 303 320 320 TRP TRP A . n A 1 304 ASP 304 321 321 ASP ASP A . n A 1 305 LYS 305 322 322 LYS LYS A . n A 1 306 SER 306 323 323 SER SER A . n A 1 307 ILE 307 324 324 ILE ILE A . n A 1 308 ILE 308 325 325 ILE ILE A . n A 1 309 GLU 309 326 326 GLU GLU A . n A 1 310 LYS 310 327 327 LYS LYS A . n A 1 311 PRO 311 328 328 PRO PRO A . n A 1 312 THR 312 329 329 THR THR A . n A 1 313 ASP 313 330 330 ASP ASP A . n A 1 314 GLY 314 331 331 GLY GLY A . n A 1 315 ARG 315 332 332 ARG ARG A . n A 1 316 ASP 316 333 333 ASP ASP A . n A 1 317 LEU 317 334 334 LEU LEU A . n A 1 318 VAL 318 335 335 VAL VAL A . n A 1 319 CYS 319 336 336 CYS CYS A . n A 1 320 HIS 320 337 337 HIS HIS A . n A 1 321 ALA 321 338 338 ALA ALA A . n A 1 322 SER 322 339 339 SER SER A . n A 1 323 ALA 323 340 340 ALA ALA A . n A 1 324 TRP 324 341 341 TRP TRP A . n A 1 325 ASP 325 342 342 ASP ASP A . n A 1 326 PHE 326 343 343 PHE PHE A . n A 1 327 TYR 327 344 344 TYR TYR A . n A 1 328 LEU 328 345 345 LEU LEU A . n A 1 329 THR 329 346 346 THR THR A . n A 1 330 ASP 330 347 347 ASP ASP A . n A 1 331 ASP 331 348 348 ASP ASP A . n A 1 332 VAL 332 349 349 VAL VAL A . n A 1 333 ARG 333 350 350 ARG ARG A . n A 1 334 ILE 334 351 351 ILE ILE A . n A 1 335 LYS 335 352 352 LYS LYS A . n A 1 336 GLN 336 353 353 GLN GLN A . n A 1 337 CYS 337 354 354 CYS CYS A . n A 1 338 THR 338 355 355 THR THR A . n A 1 339 ARG 339 356 356 ARG ARG A . n A 1 340 VAL 340 357 357 VAL VAL A . n A 1 341 THR 341 358 358 THR THR A . n A 1 342 GLN 342 359 359 GLN GLN A . n A 1 343 ASP 343 360 360 ASP ASP A . n A 1 344 GLN 344 361 361 GLN GLN A . n A 1 345 LEU 345 362 362 LEU LEU A . n A 1 346 PHE 346 363 363 PHE PHE A . n A 1 347 THR 347 364 364 THR THR A . n A 1 348 VAL 348 365 365 VAL VAL A . n A 1 349 HIS 349 366 366 HIS HIS A . n A 1 350 HIS 350 367 367 HIS HIS A . n A 1 351 GLU 351 368 368 GLU GLU A . n A 1 352 LEU 352 369 369 LEU LEU A . n A 1 353 GLY 353 370 370 GLY GLY A . n A 1 354 HIS 354 371 371 HIS HIS A . n A 1 355 ILE 355 372 372 ILE ILE A . n A 1 356 GLN 356 373 373 GLN GLN A . n A 1 357 TYR 357 374 374 TYR TYR A . n A 1 358 PHE 358 375 375 PHE PHE A . n A 1 359 LEU 359 376 376 LEU LEU A . n A 1 360 GLN 360 377 377 GLN GLN A . n A 1 361 TYR 361 378 378 TYR TYR A . n A 1 362 GLN 362 379 379 GLN GLN A . n A 1 363 HIS 363 380 380 HIS HIS A . n A 1 364 GLN 364 381 381 GLN GLN A . n A 1 365 PRO 365 382 382 PRO PRO A . n A 1 366 PHE 366 383 383 PHE PHE A . n A 1 367 VAL 367 384 384 VAL VAL A . n A 1 368 TYR 368 385 385 TYR TYR A . n A 1 369 ARG 369 386 386 ARG ARG A . n A 1 370 THR 370 387 387 THR THR A . n A 1 371 GLY 371 388 388 GLY GLY A . n A 1 372 ALA 372 389 389 ALA ALA A . n A 1 373 ASN 373 390 390 ASN ASN A . n A 1 374 PRO 374 391 391 PRO PRO A . n A 1 375 GLY 375 392 392 GLY GLY A . n A 1 376 PHE 376 393 393 PHE PHE A . n A 1 377 HIS 377 394 394 HIS HIS A . n A 1 378 GLU 378 395 395 GLU GLU A . n A 1 379 ALA 379 396 396 ALA ALA A . n A 1 380 VAL 380 397 397 VAL VAL A . n A 1 381 GLY 381 398 398 GLY GLY A . n A 1 382 ASP 382 399 399 ASP ASP A . n A 1 383 VAL 383 400 400 VAL VAL A . n A 1 384 LEU 384 401 401 LEU LEU A . n A 1 385 SER 385 402 402 SER SER A . n A 1 386 LEU 386 403 403 LEU LEU A . n A 1 387 SER 387 404 404 SER SER A . n A 1 388 VAL 388 405 405 VAL VAL A . n A 1 389 SER 389 406 406 SER SER A . n A 1 390 THR 390 407 407 THR THR A . n A 1 391 PRO 391 408 408 PRO PRO A . n A 1 392 LYS 392 409 409 LYS LYS A . n A 1 393 HIS 393 410 410 HIS HIS A . n A 1 394 LEU 394 411 411 LEU LEU A . n A 1 395 GLU 395 412 412 GLU GLU A . n A 1 396 LYS 396 413 413 LYS LYS A . n A 1 397 ILE 397 414 414 ILE ILE A . n A 1 398 GLY 398 415 415 GLY GLY A . n A 1 399 LEU 399 416 416 LEU LEU A . n A 1 400 LEU 400 417 417 LEU LEU A . n A 1 401 LYS 401 418 418 LYS LYS A . n A 1 402 ASP 402 419 419 ASP ASP A . n A 1 403 TYR 403 420 420 TYR TYR A . n A 1 404 VAL 404 421 421 VAL VAL A . n A 1 405 ARG 405 422 422 ARG ARG A . n A 1 406 ASP 406 423 423 ASP ASP A . n A 1 407 ASP 407 424 424 ASP ASP A . n A 1 408 GLU 408 425 425 GLU GLU A . n A 1 409 ALA 409 426 426 ALA ALA A . n A 1 410 ARG 410 427 427 ARG ARG A . n A 1 411 ILE 411 428 428 ILE ILE A . n A 1 412 ASN 412 429 429 ASN ASN A . n A 1 413 GLN 413 430 430 GLN GLN A . n A 1 414 LEU 414 431 431 LEU LEU A . n A 1 415 PHE 415 432 432 PHE PHE A . n A 1 416 LEU 416 433 433 LEU LEU A . n A 1 417 THR 417 434 434 THR THR A . n A 1 418 ALA 418 435 435 ALA ALA A . n A 1 419 LEU 419 436 436 LEU LEU A . n A 1 420 ASP 420 437 437 ASP ASP A . n A 1 421 LYS 421 438 438 LYS LYS A . n A 1 422 ILE 422 439 439 ILE ILE A . n A 1 423 VAL 423 440 440 VAL VAL A . n A 1 424 PHE 424 441 441 PHE PHE A . n A 1 425 LEU 425 442 442 LEU LEU A . n A 1 426 PRO 426 443 443 PRO PRO A . n A 1 427 PHE 427 444 444 PHE PHE A . n A 1 428 ALA 428 445 445 ALA ALA A . n A 1 429 PHE 429 446 446 PHE PHE A . n A 1 430 THR 430 447 447 THR THR A . n A 1 431 MET 431 448 448 MET MET A . n A 1 432 ASP 432 449 449 ASP ASP A . n A 1 433 LYS 433 450 450 LYS LYS A . n A 1 434 TYR 434 451 451 TYR TYR A . n A 1 435 ARG 435 452 452 ARG ARG A . n A 1 436 TRP 436 453 453 TRP TRP A . n A 1 437 SER 437 454 454 SER SER A . n A 1 438 LEU 438 455 455 LEU LEU A . n A 1 439 PHE 439 456 456 PHE PHE A . n A 1 440 ARG 440 457 457 ARG ARG A . n A 1 441 GLY 441 458 458 GLY GLY A . n A 1 442 GLU 442 459 459 GLU GLU A . n A 1 443 VAL 443 460 460 VAL VAL A . n A 1 444 ASP 444 461 461 ASP ASP A . n A 1 445 LYS 445 462 462 LYS LYS A . n A 1 446 ALA 446 463 463 ALA ALA A . n A 1 447 ASN 447 464 464 ASN ASN A . n A 1 448 TRP 448 465 465 TRP TRP A . n A 1 449 ASN 449 466 466 ASN ASN A . n A 1 450 CYS 450 467 467 CYS CYS A . n A 1 451 ALA 451 468 468 ALA ALA A . n A 1 452 PHE 452 469 469 PHE PHE A . n A 1 453 TRP 453 470 470 TRP TRP A . n A 1 454 LYS 454 471 471 LYS LYS A . n A 1 455 LEU 455 472 472 LEU LEU A . n A 1 456 ARG 456 473 473 ARG ARG A . n A 1 457 ASP 457 474 474 ASP ASP A . n A 1 458 GLU 458 475 475 GLU GLU A . n A 1 459 TYR 459 476 476 TYR TYR A . n A 1 460 SER 460 477 477 SER SER A . n A 1 461 GLY 461 478 478 GLY GLY A . n A 1 462 ILE 462 479 479 ILE ILE A . n A 1 463 GLU 463 480 480 GLU GLU A . n A 1 464 PRO 464 481 481 PRO PRO A . n A 1 465 PRO 465 482 482 PRO PRO A . n A 1 466 VAL 466 483 483 VAL VAL A . n A 1 467 VAL 467 484 484 VAL VAL A . n A 1 468 ARG 468 485 485 ARG ARG A . n A 1 469 SER 469 486 486 SER SER A . n A 1 470 GLU 470 487 487 GLU GLU A . n A 1 471 LYS 471 488 488 LYS LYS A . n A 1 472 ASP 472 489 489 ASP ASP A . n A 1 473 PHE 473 490 490 PHE PHE A . n A 1 474 ASP 474 491 491 ASP ASP A . n A 1 475 ALA 475 492 492 ALA ALA A . n A 1 476 PRO 476 493 493 PRO PRO A . n A 1 477 ALA 477 494 494 ALA ALA A . n A 1 478 LYS 478 495 495 LYS LYS A . n A 1 479 TYR 479 496 496 TYR TYR A . n A 1 480 HIS 480 497 497 HIS HIS A . n A 1 481 ILE 481 498 498 ILE ILE A . n A 1 482 SER 482 499 499 SER SER A . n A 1 483 ALA 483 500 500 ALA ALA A . n A 1 484 ASP 484 501 501 ASP ASP A . n A 1 485 VAL 485 502 502 VAL VAL A . n A 1 486 GLU 486 503 503 GLU GLU A . n A 1 487 TYR 487 504 504 TYR TYR A . n A 1 488 LEU 488 505 505 LEU LEU A . n A 1 489 ARG 489 506 506 ARG ARG A . n A 1 490 TYR 490 507 507 TYR TYR A . n A 1 491 LEU 491 508 508 LEU LEU A . n A 1 492 VAL 492 509 509 VAL VAL A . n A 1 493 SER 493 510 510 SER SER A . n A 1 494 PHE 494 511 511 PHE PHE A . n A 1 495 ILE 495 512 512 ILE ILE A . n A 1 496 ILE 496 513 513 ILE ILE A . n A 1 497 GLN 497 514 514 GLN GLN A . n A 1 498 PHE 498 515 515 PHE PHE A . n A 1 499 GLN 499 516 516 GLN GLN A . n A 1 500 PHE 500 517 517 PHE PHE A . n A 1 501 TYR 501 518 518 TYR TYR A . n A 1 502 LYS 502 519 519 LYS LYS A . n A 1 503 SER 503 520 520 SER SER A . n A 1 504 ALA 504 521 521 ALA ALA A . n A 1 505 CYS 505 522 522 CYS CYS A . n A 1 506 ILE 506 523 523 ILE ILE A . n A 1 507 LYS 507 524 524 LYS LYS A . n A 1 508 ALA 508 525 525 ALA ALA A . n A 1 509 GLY 509 526 526 GLY GLY A . n A 1 510 GLN 510 527 527 GLN GLN A . n A 1 511 TYR 511 528 528 TYR TYR A . n A 1 512 ASP 512 529 529 ASP ASP A . n A 1 513 PRO 513 530 530 PRO PRO A . n A 1 514 ASP 514 531 531 ASP ASP A . n A 1 515 ASN 515 532 532 ASN ASN A . n A 1 516 VAL 516 533 533 VAL VAL A . n A 1 517 GLU 517 534 534 GLU GLU A . n A 1 518 LEU 518 535 535 LEU LEU A . n A 1 519 PRO 519 536 536 PRO PRO A . n A 1 520 LEU 520 537 537 LEU LEU A . n A 1 521 ASP 521 538 538 ASP ASP A . n A 1 522 ASN 522 539 539 ASN ASN A . n A 1 523 CYS 523 540 540 CYS CYS A . n A 1 524 ASP 524 541 541 ASP ASP A . n A 1 525 ILE 525 542 542 ILE ILE A . n A 1 526 TYR 526 543 543 TYR TYR A . n A 1 527 GLY 527 544 544 GLY GLY A . n A 1 528 SER 528 545 545 SER SER A . n A 1 529 ALA 529 546 546 ALA ALA A . n A 1 530 ALA 530 547 547 ALA ALA A . n A 1 531 ALA 531 548 548 ALA ALA A . n A 1 532 GLY 532 549 549 GLY GLY A . n A 1 533 ALA 533 550 550 ALA ALA A . n A 1 534 ALA 534 551 551 ALA ALA A . n A 1 535 PHE 535 552 552 PHE PHE A . n A 1 536 HIS 536 553 553 HIS HIS A . n A 1 537 ASN 537 554 554 ASN ASN A . n A 1 538 MET 538 555 555 MET MET A . n A 1 539 LEU 539 556 556 LEU LEU A . n A 1 540 SER 540 557 557 SER SER A . n A 1 541 MET 541 558 558 MET MET A . n A 1 542 GLY 542 559 559 GLY GLY A . n A 1 543 ALA 543 560 560 ALA ALA A . n A 1 544 SER 544 561 561 SER SER A . n A 1 545 LYS 545 562 562 LYS LYS A . n A 1 546 PRO 546 563 563 PRO PRO A . n A 1 547 TRP 547 564 564 TRP TRP A . n A 1 548 PRO 548 565 565 PRO PRO A . n A 1 549 ASP 549 566 566 ASP ASP A . n A 1 550 ALA 550 567 567 ALA ALA A . n A 1 551 LEU 551 568 568 LEU LEU A . n A 1 552 GLU 552 569 569 GLU GLU A . n A 1 553 ALA 553 570 570 ALA ALA A . n A 1 554 PHE 554 571 571 PHE PHE A . n A 1 555 ASN 555 572 572 ASN ASN A . n A 1 556 GLY 556 573 573 GLY GLY A . n A 1 557 GLU 557 574 574 GLU GLU A . n A 1 558 ARG 558 575 575 ARG ARG A . n A 1 559 ILE 559 576 576 ILE ILE A . n A 1 560 MET 560 577 577 MET MET A . n A 1 561 SER 561 578 578 SER SER A . n A 1 562 GLY 562 579 579 GLY GLY A . n A 1 563 LYS 563 580 580 LYS LYS A . n A 1 564 ALA 564 581 581 ALA ALA A . n A 1 565 ILE 565 582 582 ILE ILE A . n A 1 566 ALA 566 583 583 ALA ALA A . n A 1 567 GLU 567 584 584 GLU GLU A . n A 1 568 TYR 568 585 585 TYR TYR A . n A 1 569 PHE 569 586 586 PHE PHE A . n A 1 570 GLU 570 587 587 GLU GLU A . n A 1 571 PRO 571 588 588 PRO PRO A . n A 1 572 LEU 572 589 589 LEU LEU A . n A 1 573 ARG 573 590 590 ARG ARG A . n A 1 574 VAL 574 591 591 VAL VAL A . n A 1 575 TRP 575 592 592 TRP TRP A . n A 1 576 LEU 576 593 593 LEU LEU A . n A 1 577 GLU 577 594 594 GLU GLU A . n A 1 578 ALA 578 595 595 ALA ALA A . n A 1 579 GLU 579 596 596 GLU GLU A . n A 1 580 ASN 580 597 597 ASN ASN A . n A 1 581 ILE 581 598 598 ILE ILE A . n A 1 582 LYS 582 599 599 LYS LYS A . n A 1 583 ASN 583 600 600 ASN ASN A . n A 1 584 ASN 584 601 601 ASN ASN A . n A 1 585 VAL 585 602 602 VAL VAL A . n A 1 586 HIS 586 603 603 HIS HIS A . n A 1 587 ILE 587 604 604 ILE ILE A . n A 1 588 GLY 588 605 605 GLY GLY A . n A 1 589 TRP 589 606 606 TRP TRP A . n A 1 590 THR 590 607 607 THR THR A . n A 1 591 THR 591 608 608 THR THR A . n A 1 592 SER 592 609 609 SER SER A . n A 1 593 ASN 593 610 610 ASN ASN A . n A 1 594 LYS 594 611 611 LYS LYS A . n A 1 595 CYS 595 612 612 CYS CYS A . n A 1 596 VAL 596 613 613 VAL VAL A . n A 1 597 SER 597 614 614 SER SER A . n A 1 598 SER 598 615 ? ? ? A . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code B 2 MLT 1 1615 1615 MLT MLT A . C 3 ZN 1 1616 1616 ZN ZN A . D 4 NAG 1 1621 1621 NAG NAG A . E 4 NAG 1 1622 1622 NAG NAG A . F 5 TRS 1 7002 7002 TRS TRS A . G 6 HOH 1 2001 2001 HOH HOH A . G 6 HOH 2 2002 2002 HOH HOH A . G 6 HOH 3 2003 2003 HOH HOH A . G 6 HOH 4 2004 2004 HOH HOH A . G 6 HOH 5 2005 2005 HOH HOH A . G 6 HOH 6 2006 2006 HOH HOH A . G 6 HOH 7 2007 2007 HOH HOH A . G 6 HOH 8 2008 2008 HOH HOH A . G 6 HOH 9 2009 2009 HOH HOH A . G 6 HOH 10 2010 2010 HOH HOH A . G 6 HOH 11 2011 2011 HOH HOH A . G 6 HOH 12 2012 2012 HOH HOH A . G 6 HOH 13 2013 2013 HOH HOH A . G 6 HOH 14 2014 2014 HOH HOH A . G 6 HOH 15 2015 2015 HOH HOH A . G 6 HOH 16 2016 2016 HOH HOH A . G 6 HOH 17 2017 2017 HOH HOH A . G 6 HOH 18 2018 2018 HOH HOH A . G 6 HOH 19 2019 2019 HOH HOH A . G 6 HOH 20 2020 2020 HOH HOH A . G 6 HOH 21 2021 2021 HOH HOH A . G 6 HOH 22 2022 2022 HOH HOH A . G 6 HOH 23 2023 2023 HOH HOH A . G 6 HOH 24 2024 2024 HOH HOH A . G 6 HOH 25 2025 2025 HOH HOH A . G 6 HOH 26 2026 2026 HOH HOH A . G 6 HOH 27 2027 2027 HOH HOH A . G 6 HOH 28 2028 2028 HOH HOH A . G 6 HOH 29 2029 2029 HOH HOH A . G 6 HOH 30 2030 2030 HOH HOH A . G 6 HOH 31 2031 2031 HOH HOH A . G 6 HOH 32 2032 2032 HOH HOH A . G 6 HOH 33 2033 2033 HOH HOH A . G 6 HOH 34 2034 2034 HOH HOH A . G 6 HOH 35 2035 2035 HOH HOH A . G 6 HOH 36 2036 2036 HOH HOH A . G 6 HOH 37 2037 2037 HOH HOH A . G 6 HOH 38 2038 2038 HOH HOH A . G 6 HOH 39 2039 2039 HOH HOH A . G 6 HOH 40 2040 2040 HOH HOH A . G 6 HOH 41 2041 2041 HOH HOH A . G 6 HOH 42 2042 2042 HOH HOH A . G 6 HOH 43 2043 2043 HOH HOH A . G 6 HOH 44 2044 2044 HOH HOH A . G 6 HOH 45 2045 2045 HOH HOH A . G 6 HOH 46 2046 2046 HOH HOH A . G 6 HOH 47 2047 2047 HOH HOH A . G 6 HOH 48 2048 2048 HOH HOH A . G 6 HOH 49 2049 2049 HOH HOH A . G 6 HOH 50 2050 2050 HOH HOH A . G 6 HOH 51 2051 2051 HOH HOH A . G 6 HOH 52 2052 2052 HOH HOH A . G 6 HOH 53 2053 2053 HOH HOH A . G 6 HOH 54 2054 2054 HOH HOH A . G 6 HOH 55 2055 2055 HOH HOH A . G 6 HOH 56 2056 2056 HOH HOH A . G 6 HOH 57 2057 2057 HOH HOH A . G 6 HOH 58 2058 2058 HOH HOH A . G 6 HOH 59 2059 2059 HOH HOH A . G 6 HOH 60 2060 2060 HOH HOH A . G 6 HOH 61 2061 2061 HOH HOH A . G 6 HOH 62 2062 2062 HOH HOH A . G 6 HOH 63 2063 2063 HOH HOH A . G 6 HOH 64 2064 2064 HOH HOH A . G 6 HOH 65 2065 2065 HOH HOH A . G 6 HOH 66 2066 2066 HOH HOH A . G 6 HOH 67 2067 2067 HOH HOH A . G 6 HOH 68 2068 2068 HOH HOH A . G 6 HOH 69 2069 2069 HOH HOH A . G 6 HOH 70 2070 2070 HOH HOH A . G 6 HOH 71 2071 2071 HOH HOH A . G 6 HOH 72 2072 2072 HOH HOH A . G 6 HOH 73 2073 2073 HOH HOH A . G 6 HOH 74 2074 2074 HOH HOH A . G 6 HOH 75 2075 2075 HOH HOH A . G 6 HOH 76 2076 2076 HOH HOH A . G 6 HOH 77 2077 2077 HOH HOH A . G 6 HOH 78 2078 2078 HOH HOH A . G 6 HOH 79 2079 2079 HOH HOH A . G 6 HOH 80 2080 2080 HOH HOH A . G 6 HOH 81 2081 2081 HOH HOH A . G 6 HOH 82 2082 2082 HOH HOH A . G 6 HOH 83 2083 2083 HOH HOH A . G 6 HOH 84 2084 2084 HOH HOH A . G 6 HOH 85 2085 2085 HOH HOH A . G 6 HOH 86 2086 2086 HOH HOH A . G 6 HOH 87 2087 2087 HOH HOH A . G 6 HOH 88 2088 2088 HOH HOH A . G 6 HOH 89 2089 2089 HOH HOH A . G 6 HOH 90 2090 2090 HOH HOH A . G 6 HOH 91 2091 2091 HOH HOH A . G 6 HOH 92 2092 2092 HOH HOH A . G 6 HOH 93 2093 2093 HOH HOH A . G 6 HOH 94 2094 2094 HOH HOH A . G 6 HOH 95 2095 2095 HOH HOH A . G 6 HOH 96 2096 2096 HOH HOH A . G 6 HOH 97 2097 2097 HOH HOH A . G 6 HOH 98 2098 2098 HOH HOH A . G 6 HOH 99 2099 2099 HOH HOH A . G 6 HOH 100 2100 2100 HOH HOH A . G 6 HOH 101 2101 2101 HOH HOH A . G 6 HOH 102 2102 2102 HOH HOH A . G 6 HOH 103 2103 2103 HOH HOH A . G 6 HOH 104 2104 2104 HOH HOH A . G 6 HOH 105 2105 2105 HOH HOH A . G 6 HOH 106 2106 2106 HOH HOH A . G 6 HOH 107 2107 2107 HOH HOH A . G 6 HOH 108 2108 2108 HOH HOH A . G 6 HOH 109 2109 2109 HOH HOH A . G 6 HOH 110 2110 2110 HOH HOH A . G 6 HOH 111 2111 2111 HOH HOH A . G 6 HOH 112 2112 2112 HOH HOH A . G 6 HOH 113 2113 2113 HOH HOH A . G 6 HOH 114 2114 2114 HOH HOH A . G 6 HOH 115 2115 2115 HOH HOH A . G 6 HOH 116 2116 2116 HOH HOH A . G 6 HOH 117 2117 2117 HOH HOH A . G 6 HOH 118 2118 2118 HOH HOH A . G 6 HOH 119 2119 2119 HOH HOH A . G 6 HOH 120 2120 2120 HOH HOH A . G 6 HOH 121 2121 2121 HOH HOH A . G 6 HOH 122 2122 2122 HOH HOH A . G 6 HOH 123 2123 2123 HOH HOH A . G 6 HOH 124 2124 2124 HOH HOH A . G 6 HOH 125 2125 2125 HOH HOH A . G 6 HOH 126 2126 2126 HOH HOH A . G 6 HOH 127 2127 2127 HOH HOH A . G 6 HOH 128 2128 2128 HOH HOH A . G 6 HOH 129 2129 2129 HOH HOH A . G 6 HOH 130 2130 2130 HOH HOH A . G 6 HOH 131 2131 2131 HOH HOH A . G 6 HOH 132 2132 2132 HOH HOH A . G 6 HOH 133 2133 2133 HOH HOH A . G 6 HOH 134 2134 2134 HOH HOH A . G 6 HOH 135 2135 2135 HOH HOH A . G 6 HOH 136 2136 2136 HOH HOH A . G 6 HOH 137 2137 2137 HOH HOH A . G 6 HOH 138 2138 2138 HOH HOH A . G 6 HOH 139 2139 2139 HOH HOH A . G 6 HOH 140 2140 2140 HOH HOH A . G 6 HOH 141 2141 2141 HOH HOH A . G 6 HOH 142 2142 2142 HOH HOH A . G 6 HOH 143 2143 2143 HOH HOH A . G 6 HOH 144 2144 2144 HOH HOH A . G 6 HOH 145 2145 2145 HOH HOH A . G 6 HOH 146 2146 2146 HOH HOH A . G 6 HOH 147 2147 2147 HOH HOH A . G 6 HOH 148 2148 2148 HOH HOH A . G 6 HOH 149 2149 2149 HOH HOH A . G 6 HOH 150 2150 2150 HOH HOH A . G 6 HOH 151 2151 2151 HOH HOH A . G 6 HOH 152 2152 2152 HOH HOH A . G 6 HOH 153 2153 2153 HOH HOH A . G 6 HOH 154 2154 2154 HOH HOH A . G 6 HOH 155 2155 2155 HOH HOH A . G 6 HOH 156 2156 2156 HOH HOH A . G 6 HOH 157 2157 2157 HOH HOH A . G 6 HOH 158 2158 2158 HOH HOH A . G 6 HOH 159 2159 2159 HOH HOH A . G 6 HOH 160 2160 2160 HOH HOH A . G 6 HOH 161 2161 2161 HOH HOH A . G 6 HOH 162 2162 2162 HOH HOH A . G 6 HOH 163 2163 2163 HOH HOH A . G 6 HOH 164 2164 2164 HOH HOH A . G 6 HOH 165 2165 2165 HOH HOH A . G 6 HOH 166 2166 2166 HOH HOH A . G 6 HOH 167 2167 2167 HOH HOH A . G 6 HOH 168 2168 2168 HOH HOH A . G 6 HOH 169 2169 2169 HOH HOH A . G 6 HOH 170 2170 2170 HOH HOH A . G 6 HOH 171 2171 2171 HOH HOH A . G 6 HOH 172 2172 2172 HOH HOH A . G 6 HOH 173 2173 2173 HOH HOH A . G 6 HOH 174 2174 2174 HOH HOH A . G 6 HOH 175 2175 2175 HOH HOH A . G 6 HOH 176 2176 2176 HOH HOH A . G 6 HOH 177 2177 2177 HOH HOH A . G 6 HOH 178 2178 2178 HOH HOH A . G 6 HOH 179 2179 2179 HOH HOH A . G 6 HOH 180 2180 2180 HOH HOH A . G 6 HOH 181 2181 2181 HOH HOH A . G 6 HOH 182 2182 2182 HOH HOH A . G 6 HOH 183 2183 2183 HOH HOH A . G 6 HOH 184 2184 2184 HOH HOH A . G 6 HOH 185 2185 2185 HOH HOH A . G 6 HOH 186 2186 2186 HOH HOH A . G 6 HOH 187 2187 2187 HOH HOH A . G 6 HOH 188 2188 2188 HOH HOH A . G 6 HOH 189 2189 2189 HOH HOH A . G 6 HOH 190 2190 2190 HOH HOH A . G 6 HOH 191 2191 2191 HOH HOH A . G 6 HOH 192 2192 2192 HOH HOH A . G 6 HOH 193 2193 2193 HOH HOH A . G 6 HOH 194 2194 2194 HOH HOH A . G 6 HOH 195 2195 2195 HOH HOH A . G 6 HOH 196 2196 2196 HOH HOH A . G 6 HOH 197 2197 2197 HOH HOH A . G 6 HOH 198 2198 2198 HOH HOH A . G 6 HOH 199 2199 2199 HOH HOH A . G 6 HOH 200 2200 2200 HOH HOH A . G 6 HOH 201 2201 2201 HOH HOH A . G 6 HOH 202 2202 2202 HOH HOH A . G 6 HOH 203 2203 2203 HOH HOH A . G 6 HOH 204 2204 2204 HOH HOH A . G 6 HOH 205 2205 2205 HOH HOH A . G 6 HOH 206 2206 2206 HOH HOH A . G 6 HOH 207 2207 2207 HOH HOH A . G 6 HOH 208 2208 2208 HOH HOH A . G 6 HOH 209 2209 2209 HOH HOH A . G 6 HOH 210 2210 2210 HOH HOH A . G 6 HOH 211 2211 2211 HOH HOH A . G 6 HOH 212 2212 2212 HOH HOH A . G 6 HOH 213 2213 2213 HOH HOH A . G 6 HOH 214 2214 2214 HOH HOH A . G 6 HOH 215 2215 2215 HOH HOH A . G 6 HOH 216 2216 2216 HOH HOH A . G 6 HOH 217 2217 2217 HOH HOH A . G 6 HOH 218 2218 2218 HOH HOH A . G 6 HOH 219 2219 2219 HOH HOH A . G 6 HOH 220 2220 2220 HOH HOH A . G 6 HOH 221 2221 2221 HOH HOH A . G 6 HOH 222 2222 2222 HOH HOH A . G 6 HOH 223 2223 2223 HOH HOH A . G 6 HOH 224 2224 2224 HOH HOH A . G 6 HOH 225 2225 2225 HOH HOH A . G 6 HOH 226 2226 2226 HOH HOH A . G 6 HOH 227 2227 2227 HOH HOH A . G 6 HOH 228 2228 2228 HOH HOH A . G 6 HOH 229 2229 2229 HOH HOH A . G 6 HOH 230 2230 2230 HOH HOH A . G 6 HOH 231 2231 2231 HOH HOH A . G 6 HOH 232 2232 2232 HOH HOH A . G 6 HOH 233 2233 2233 HOH HOH A . G 6 HOH 234 2234 2234 HOH HOH A . G 6 HOH 235 2235 2235 HOH HOH A . G 6 HOH 236 2236 2236 HOH HOH A . G 6 HOH 237 2237 2237 HOH HOH A . G 6 HOH 238 2238 2238 HOH HOH A . G 6 HOH 239 2239 2239 HOH HOH A . G 6 HOH 240 2240 2240 HOH HOH A . G 6 HOH 241 2241 2241 HOH HOH A . G 6 HOH 242 2242 2242 HOH HOH A . G 6 HOH 243 2243 2243 HOH HOH A . G 6 HOH 244 2244 2244 HOH HOH A . G 6 HOH 245 2245 2245 HOH HOH A . G 6 HOH 246 2246 2246 HOH HOH A . G 6 HOH 247 2247 2247 HOH HOH A . G 6 HOH 248 2248 2248 HOH HOH A . G 6 HOH 249 2249 2249 HOH HOH A . G 6 HOH 250 2250 2250 HOH HOH A . G 6 HOH 251 2251 2251 HOH HOH A . G 6 HOH 252 2252 2252 HOH HOH A . G 6 HOH 253 2253 2253 HOH HOH A . G 6 HOH 254 2254 2254 HOH HOH A . G 6 HOH 255 2255 2255 HOH HOH A . G 6 HOH 256 2256 2256 HOH HOH A . G 6 HOH 257 2257 2257 HOH HOH A . G 6 HOH 258 2258 2258 HOH HOH A . G 6 HOH 259 2259 2259 HOH HOH A . G 6 HOH 260 2260 2260 HOH HOH A . G 6 HOH 261 2261 2261 HOH HOH A . G 6 HOH 262 2262 2262 HOH HOH A . G 6 HOH 263 2263 2263 HOH HOH A . G 6 HOH 264 2264 2264 HOH HOH A . G 6 HOH 265 2265 2265 HOH HOH A . G 6 HOH 266 2266 2266 HOH HOH A . G 6 HOH 267 2267 2267 HOH HOH A . G 6 HOH 268 2268 2268 HOH HOH A . G 6 HOH 269 2269 2269 HOH HOH A . G 6 HOH 270 2270 2270 HOH HOH A . G 6 HOH 271 2271 2271 HOH HOH A . G 6 HOH 272 2272 2272 HOH HOH A . G 6 HOH 273 2273 2273 HOH HOH A . G 6 HOH 274 2274 2274 HOH HOH A . G 6 HOH 275 2275 2275 HOH HOH A . G 6 HOH 276 2276 2276 HOH HOH A . G 6 HOH 277 2277 2277 HOH HOH A . G 6 HOH 278 2278 2278 HOH HOH A . G 6 HOH 279 2279 2279 HOH HOH A . G 6 HOH 280 2280 2280 HOH HOH A . G 6 HOH 281 2281 2281 HOH HOH A . G 6 HOH 282 2282 2282 HOH HOH A . G 6 HOH 283 2283 2283 HOH HOH A . G 6 HOH 284 2284 2284 HOH HOH A . G 6 HOH 285 2285 2285 HOH HOH A . G 6 HOH 286 2286 2286 HOH HOH A . G 6 HOH 287 2287 2287 HOH HOH A . G 6 HOH 288 2288 2288 HOH HOH A . G 6 HOH 289 2289 2289 HOH HOH A . G 6 HOH 290 2290 2290 HOH HOH A . G 6 HOH 291 2291 2291 HOH HOH A . G 6 HOH 292 2292 2292 HOH HOH A . G 6 HOH 293 2293 2293 HOH HOH A . G 6 HOH 294 2294 2294 HOH HOH A . G 6 HOH 295 2295 2295 HOH HOH A . G 6 HOH 296 2296 2296 HOH HOH A . G 6 HOH 297 2297 2297 HOH HOH A . G 6 HOH 298 2298 2298 HOH HOH A . G 6 HOH 299 2299 2299 HOH HOH A . G 6 HOH 300 2300 2300 HOH HOH A . G 6 HOH 301 2301 2301 HOH HOH A . G 6 HOH 302 2302 2302 HOH HOH A . G 6 HOH 303 2303 2303 HOH HOH A . G 6 HOH 304 2304 2304 HOH HOH A . G 6 HOH 305 2305 2305 HOH HOH A . G 6 HOH 306 2306 2306 HOH HOH A . G 6 HOH 307 2307 2307 HOH HOH A . G 6 HOH 308 2308 2308 HOH HOH A . G 6 HOH 309 2309 2309 HOH HOH A . G 6 HOH 310 2310 2310 HOH HOH A . G 6 HOH 311 2311 2311 HOH HOH A . G 6 HOH 312 2312 2312 HOH HOH A . G 6 HOH 313 2313 2313 HOH HOH A . G 6 HOH 314 2314 2314 HOH HOH A . G 6 HOH 315 2315 2315 HOH HOH A . G 6 HOH 316 2316 2316 HOH HOH A . G 6 HOH 317 2317 2317 HOH HOH A . G 6 HOH 318 2318 2318 HOH HOH A . G 6 HOH 319 2319 2319 HOH HOH A . G 6 HOH 320 2320 2320 HOH HOH A . G 6 HOH 321 2321 2321 HOH HOH A . G 6 HOH 322 2322 2322 HOH HOH A . G 6 HOH 323 2323 2323 HOH HOH A . G 6 HOH 324 2324 2324 HOH HOH A . G 6 HOH 325 2325 2325 HOH HOH A . G 6 HOH 326 2326 2326 HOH HOH A . G 6 HOH 327 2327 2327 HOH HOH A . G 6 HOH 328 2328 2328 HOH HOH A . G 6 HOH 329 2329 2329 HOH HOH A . G 6 HOH 330 2330 2330 HOH HOH A . G 6 HOH 331 2331 2331 HOH HOH A . G 6 HOH 332 2332 2332 HOH HOH A . G 6 HOH 333 2333 2333 HOH HOH A . G 6 HOH 334 2334 2334 HOH HOH A . G 6 HOH 335 2335 2335 HOH HOH A . G 6 HOH 336 2336 2336 HOH HOH A . G 6 HOH 337 2337 2337 HOH HOH A . G 6 HOH 338 2338 2338 HOH HOH A . G 6 HOH 339 2339 2339 HOH HOH A . G 6 HOH 340 2340 2340 HOH HOH A . G 6 HOH 341 2341 2341 HOH HOH A . G 6 HOH 342 2342 2342 HOH HOH A . G 6 HOH 343 2343 2343 HOH HOH A . G 6 HOH 344 2344 2344 HOH HOH A . G 6 HOH 345 2345 2345 HOH HOH A . G 6 HOH 346 2346 2346 HOH HOH A . G 6 HOH 347 2347 2347 HOH HOH A . G 6 HOH 348 2348 2348 HOH HOH A . G 6 HOH 349 2349 2349 HOH HOH A . G 6 HOH 350 2350 2350 HOH HOH A . G 6 HOH 351 2351 2351 HOH HOH A . G 6 HOH 352 2352 2352 HOH HOH A . G 6 HOH 353 2353 2353 HOH HOH A . G 6 HOH 354 2354 2354 HOH HOH A . G 6 HOH 355 2355 2355 HOH HOH A . G 6 HOH 356 2356 2356 HOH HOH A . G 6 HOH 357 2357 2357 HOH HOH A . G 6 HOH 358 2358 2358 HOH HOH A . G 6 HOH 359 2359 2359 HOH HOH A . G 6 HOH 360 2360 2360 HOH HOH A . G 6 HOH 361 2361 2361 HOH HOH A . G 6 HOH 362 2362 2362 HOH HOH A . G 6 HOH 363 2363 2363 HOH HOH A . G 6 HOH 364 2364 2364 HOH HOH A . G 6 HOH 365 2365 2365 HOH HOH A . G 6 HOH 366 2366 2366 HOH HOH A . G 6 HOH 367 2367 2367 HOH HOH A . G 6 HOH 368 2368 2368 HOH HOH A . G 6 HOH 369 2369 2369 HOH HOH A . G 6 HOH 370 2370 2370 HOH HOH A . G 6 HOH 371 2371 2371 HOH HOH A . G 6 HOH 372 2372 2372 HOH HOH A . G 6 HOH 373 2373 2373 HOH HOH A . G 6 HOH 374 2374 2374 HOH HOH A . G 6 HOH 375 2375 2375 HOH HOH A . G 6 HOH 376 2376 2376 HOH HOH A . G 6 HOH 377 2377 2377 HOH HOH A . G 6 HOH 378 2378 2378 HOH HOH A . G 6 HOH 379 2379 2379 HOH HOH A . G 6 HOH 380 2380 2380 HOH HOH A . G 6 HOH 381 2381 2381 HOH HOH A . G 6 HOH 382 2382 2382 HOH HOH A . G 6 HOH 383 2383 2383 HOH HOH A . G 6 HOH 384 2384 2384 HOH HOH A . G 6 HOH 385 2385 2385 HOH HOH A . G 6 HOH 386 2386 2386 HOH HOH A . G 6 HOH 387 2387 2387 HOH HOH A . G 6 HOH 388 2388 2388 HOH HOH A . G 6 HOH 389 2389 2389 HOH HOH A . G 6 HOH 390 2390 2390 HOH HOH A . G 6 HOH 391 2391 2391 HOH HOH A . G 6 HOH 392 2392 2392 HOH HOH A . G 6 HOH 393 2393 2393 HOH HOH A . G 6 HOH 394 2394 2394 HOH HOH A . G 6 HOH 395 2395 2395 HOH HOH A . G 6 HOH 396 2396 2396 HOH HOH A . G 6 HOH 397 2397 2397 HOH HOH A . G 6 HOH 398 2398 2398 HOH HOH A . G 6 HOH 399 2399 2399 HOH HOH A . G 6 HOH 400 2400 2400 HOH HOH A . G 6 HOH 401 2401 2401 HOH HOH A . G 6 HOH 402 2402 2402 HOH HOH A . G 6 HOH 403 2403 2403 HOH HOH A . G 6 HOH 404 2404 2404 HOH HOH A . G 6 HOH 405 2405 2405 HOH HOH A . G 6 HOH 406 2406 2406 HOH HOH A . G 6 HOH 407 2407 2407 HOH HOH A . G 6 HOH 408 2408 2408 HOH HOH A . G 6 HOH 409 2409 2409 HOH HOH A . G 6 HOH 410 2410 2410 HOH HOH A . G 6 HOH 411 2411 2411 HOH HOH A . G 6 HOH 412 2412 2412 HOH HOH A . G 6 HOH 413 2413 2413 HOH HOH A . G 6 HOH 414 2414 2414 HOH HOH A . G 6 HOH 415 2415 2415 HOH HOH A . G 6 HOH 416 2416 2416 HOH HOH A . G 6 HOH 417 2417 2417 HOH HOH A . G 6 HOH 418 2418 2418 HOH HOH A . G 6 HOH 419 2419 2419 HOH HOH A . G 6 HOH 420 2420 2420 HOH HOH A . G 6 HOH 421 2421 2421 HOH HOH A . G 6 HOH 422 2422 2422 HOH HOH A . G 6 HOH 423 2423 2423 HOH HOH A . G 6 HOH 424 2424 2424 HOH HOH A . G 6 HOH 425 2425 2425 HOH HOH A . G 6 HOH 426 2426 2426 HOH HOH A . G 6 HOH 427 2427 2427 HOH HOH A . G 6 HOH 428 2428 2428 HOH HOH A . G 6 HOH 429 2429 2429 HOH HOH A . G 6 HOH 430 2430 2430 HOH HOH A . G 6 HOH 431 2431 2431 HOH HOH A . G 6 HOH 432 2432 2432 HOH HOH A . G 6 HOH 433 2433 2433 HOH HOH A . G 6 HOH 434 2434 2434 HOH HOH A . G 6 HOH 435 2435 2435 HOH HOH A . G 6 HOH 436 2436 2436 HOH HOH A . G 6 HOH 437 2437 2437 HOH HOH A . G 6 HOH 438 2438 2438 HOH HOH A . G 6 HOH 439 2439 2439 HOH HOH A . G 6 HOH 440 2440 2440 HOH HOH A . G 6 HOH 441 2441 2441 HOH HOH A . G 6 HOH 442 2442 2442 HOH HOH A . G 6 HOH 443 2443 2443 HOH HOH A . G 6 HOH 444 2444 2444 HOH HOH A . G 6 HOH 445 2445 2445 HOH HOH A . G 6 HOH 446 2446 2446 HOH HOH A . G 6 HOH 447 2447 2447 HOH HOH A . G 6 HOH 448 2448 2448 HOH HOH A . G 6 HOH 449 2449 2449 HOH HOH A . G 6 HOH 450 2450 2450 HOH HOH A . G 6 HOH 451 2451 2451 HOH HOH A . G 6 HOH 452 2452 2452 HOH HOH A . G 6 HOH 453 2453 2453 HOH HOH A . G 6 HOH 454 2454 2454 HOH HOH A . G 6 HOH 455 2455 2455 HOH HOH A . G 6 HOH 456 2456 2456 HOH HOH A . G 6 HOH 457 2457 2457 HOH HOH A . G 6 HOH 458 2458 2458 HOH HOH A . G 6 HOH 459 2459 2459 HOH HOH A . G 6 HOH 460 2460 2460 HOH HOH A . G 6 HOH 461 2461 2461 HOH HOH A . G 6 HOH 462 2462 2462 HOH HOH A . G 6 HOH 463 2463 2463 HOH HOH A . G 6 HOH 464 2464 2464 HOH HOH A . G 6 HOH 465 2465 2465 HOH HOH A . G 6 HOH 466 2466 2466 HOH HOH A . G 6 HOH 467 2467 2467 HOH HOH A . G 6 HOH 468 2468 2468 HOH HOH A . G 6 HOH 469 2469 2469 HOH HOH A . G 6 HOH 470 2470 2470 HOH HOH A . G 6 HOH 471 2471 2471 HOH HOH A . G 6 HOH 472 2472 2472 HOH HOH A . G 6 HOH 473 2473 2473 HOH HOH A . G 6 HOH 474 2474 2474 HOH HOH A . G 6 HOH 475 2475 2475 HOH HOH A . G 6 HOH 476 2476 2476 HOH HOH A . G 6 HOH 477 2477 2477 HOH HOH A . G 6 HOH 478 2478 2478 HOH HOH A . G 6 HOH 479 2479 2479 HOH HOH A . G 6 HOH 480 2480 2480 HOH HOH A . G 6 HOH 481 2481 2481 HOH HOH A . G 6 HOH 482 2482 2482 HOH HOH A . G 6 HOH 483 2483 2483 HOH HOH A . G 6 HOH 484 2484 2484 HOH HOH A . G 6 HOH 485 2485 2485 HOH HOH A . G 6 HOH 486 2486 2486 HOH HOH A . G 6 HOH 487 2487 2487 HOH HOH A . G 6 HOH 488 2488 2488 HOH HOH A . G 6 HOH 489 2489 2489 HOH HOH A . G 6 HOH 490 2490 2490 HOH HOH A . G 6 HOH 491 2491 2491 HOH HOH A . G 6 HOH 492 2492 2492 HOH HOH A . G 6 HOH 493 2493 2493 HOH HOH A . G 6 HOH 494 2494 2494 HOH HOH A . G 6 HOH 495 2495 2495 HOH HOH A . G 6 HOH 496 2496 2496 HOH HOH A . G 6 HOH 497 2497 2497 HOH HOH A . G 6 HOH 498 2498 2498 HOH HOH A . G 6 HOH 499 2499 2499 HOH HOH A . G 6 HOH 500 2500 2500 HOH HOH A . G 6 HOH 501 2501 2501 HOH HOH A . G 6 HOH 502 2502 2502 HOH HOH A . G 6 HOH 503 2503 2503 HOH HOH A . G 6 HOH 504 2504 2504 HOH HOH A . G 6 HOH 505 2505 2505 HOH HOH A . G 6 HOH 506 2506 2506 HOH HOH A . G 6 HOH 507 2507 2507 HOH HOH A . G 6 HOH 508 2508 2508 HOH HOH A . G 6 HOH 509 2509 2509 HOH HOH A . G 6 HOH 510 2510 2510 HOH HOH A . G 6 HOH 511 2511 2511 HOH HOH A . G 6 HOH 512 2512 2512 HOH HOH A . G 6 HOH 513 2513 2513 HOH HOH A . G 6 HOH 514 2514 2514 HOH HOH A . G 6 HOH 515 2515 2515 HOH HOH A . G 6 HOH 516 2516 2516 HOH HOH A . G 6 HOH 517 2517 2517 HOH HOH A . G 6 HOH 518 2518 2518 HOH HOH A . G 6 HOH 519 2519 2519 HOH HOH A . G 6 HOH 520 2520 2520 HOH HOH A . G 6 HOH 521 2521 2521 HOH HOH A . G 6 HOH 522 2522 2522 HOH HOH A . G 6 HOH 523 2523 2523 HOH HOH A . G 6 HOH 524 2524 2524 HOH HOH A . G 6 HOH 525 2525 2525 HOH HOH A . G 6 HOH 526 2526 2526 HOH HOH A . G 6 HOH 527 2527 2527 HOH HOH A . G 6 HOH 528 2528 2528 HOH HOH A . G 6 HOH 529 2529 2529 HOH HOH A . G 6 HOH 530 2530 2530 HOH HOH A . G 6 HOH 531 2531 2531 HOH HOH A . G 6 HOH 532 2532 2532 HOH HOH A . G 6 HOH 533 2533 2533 HOH HOH A . G 6 HOH 534 2534 2534 HOH HOH A . G 6 HOH 535 2535 2535 HOH HOH A . G 6 HOH 536 2536 2536 HOH HOH A . G 6 HOH 537 2537 2537 HOH HOH A . G 6 HOH 538 2538 2538 HOH HOH A . G 6 HOH 539 2539 2539 HOH HOH A . G 6 HOH 540 2540 2540 HOH HOH A . G 6 HOH 541 2541 2541 HOH HOH A . G 6 HOH 542 2542 2542 HOH HOH A . G 6 HOH 543 2543 2543 HOH HOH A . G 6 HOH 544 2544 2544 HOH HOH A . G 6 HOH 545 2545 2545 HOH HOH A . G 6 HOH 546 2546 2546 HOH HOH A . G 6 HOH 547 2547 2547 HOH HOH A . G 6 HOH 548 2548 2548 HOH HOH A . G 6 HOH 549 2549 2549 HOH HOH A . G 6 HOH 550 2550 2550 HOH HOH A . G 6 HOH 551 2551 2551 HOH HOH A . G 6 HOH 552 2552 2552 HOH HOH A . G 6 HOH 553 2553 2553 HOH HOH A . G 6 HOH 554 2554 2554 HOH HOH A . G 6 HOH 555 2555 2555 HOH HOH A . G 6 HOH 556 2556 2556 HOH HOH A . G 6 HOH 557 2557 2557 HOH HOH A . G 6 HOH 558 2558 2558 HOH HOH A . G 6 HOH 559 2559 2559 HOH HOH A . G 6 HOH 560 2560 2560 HOH HOH A . G 6 HOH 561 2561 2561 HOH HOH A . G 6 HOH 562 2562 2562 HOH HOH A . G 6 HOH 563 2563 2563 HOH HOH A . G 6 HOH 564 2564 2564 HOH HOH A . G 6 HOH 565 2565 2565 HOH HOH A . G 6 HOH 566 2566 2566 HOH HOH A . G 6 HOH 567 2567 2567 HOH HOH A . G 6 HOH 568 2568 2568 HOH HOH A . G 6 HOH 569 2569 2569 HOH HOH A . G 6 HOH 570 2570 2570 HOH HOH A . G 6 HOH 571 2571 2571 HOH HOH A . G 6 HOH 572 2572 2572 HOH HOH A . G 6 HOH 573 2573 2573 HOH HOH A . G 6 HOH 574 2574 2574 HOH HOH A . G 6 HOH 575 2575 2575 HOH HOH A . G 6 HOH 576 2576 2576 HOH HOH A . G 6 HOH 577 2577 2577 HOH HOH A . G 6 HOH 578 2578 2578 HOH HOH A . G 6 HOH 579 2579 2579 HOH HOH A . G 6 HOH 580 2580 2580 HOH HOH A . G 6 HOH 581 2581 2581 HOH HOH A . G 6 HOH 582 2582 2582 HOH HOH A . G 6 HOH 583 2583 2583 HOH HOH A . G 6 HOH 584 2584 2584 HOH HOH A . G 6 HOH 585 2585 2585 HOH HOH A . G 6 HOH 586 2586 2586 HOH HOH A . G 6 HOH 587 2587 2587 HOH HOH A . G 6 HOH 588 2588 2588 HOH HOH A . G 6 HOH 589 2589 2589 HOH HOH A . G 6 HOH 590 2590 2590 HOH HOH A . G 6 HOH 591 2591 2591 HOH HOH A . G 6 HOH 592 2592 2592 HOH HOH A . G 6 HOH 593 2593 2593 HOH HOH A . G 6 HOH 594 2594 2594 HOH HOH A . G 6 HOH 595 2595 2595 HOH HOH A . G 6 HOH 596 2596 2596 HOH HOH A . G 6 HOH 597 2597 2597 HOH HOH A . G 6 HOH 598 2598 2598 HOH HOH A . G 6 HOH 599 2599 2599 HOH HOH A . G 6 HOH 600 2600 2600 HOH HOH A . G 6 HOH 601 2601 2601 HOH HOH A . G 6 HOH 602 2602 2602 HOH HOH A . G 6 HOH 603 2603 2603 HOH HOH A . G 6 HOH 604 2604 2604 HOH HOH A . G 6 HOH 605 2605 2605 HOH HOH A . G 6 HOH 606 2606 2606 HOH HOH A . G 6 HOH 607 2607 2607 HOH HOH A . G 6 HOH 608 2608 2608 HOH HOH A . G 6 HOH 609 2609 2609 HOH HOH A . G 6 HOH 610 2610 2610 HOH HOH A . G 6 HOH 611 2611 2611 HOH HOH A . G 6 HOH 612 2612 2612 HOH HOH A . G 6 HOH 613 2613 2613 HOH HOH A . G 6 HOH 614 2614 2614 HOH HOH A . G 6 HOH 615 2615 2615 HOH HOH A . G 6 HOH 616 2616 2616 HOH HOH A . G 6 HOH 617 2617 2617 HOH HOH A . G 6 HOH 618 2618 2618 HOH HOH A . G 6 HOH 619 2619 2619 HOH HOH A . G 6 HOH 620 2620 2620 HOH HOH A . G 6 HOH 621 2621 2621 HOH HOH A . G 6 HOH 622 2622 2622 HOH HOH A . G 6 HOH 623 2623 2623 HOH HOH A . G 6 HOH 624 2624 2624 HOH HOH A . G 6 HOH 625 2625 2625 HOH HOH A . G 6 HOH 626 2626 2626 HOH HOH A . G 6 HOH 627 2627 2627 HOH HOH A . G 6 HOH 628 2628 2628 HOH HOH A . G 6 HOH 629 2629 2629 HOH HOH A . G 6 HOH 630 2630 2630 HOH HOH A . G 6 HOH 631 2631 2631 HOH HOH A . G 6 HOH 632 2632 2632 HOH HOH A . G 6 HOH 633 2633 2633 HOH HOH A . G 6 HOH 634 2634 2634 HOH HOH A . G 6 HOH 635 2635 2635 HOH HOH A . G 6 HOH 636 2636 2636 HOH HOH A . G 6 HOH 637 2637 2637 HOH HOH A . G 6 HOH 638 2638 2638 HOH HOH A . G 6 HOH 639 2639 2639 HOH HOH A . G 6 HOH 640 2640 2640 HOH HOH A . G 6 HOH 641 2641 2641 HOH HOH A . G 6 HOH 642 2642 2642 HOH HOH A . G 6 HOH 643 2643 2643 HOH HOH A . G 6 HOH 644 2644 2644 HOH HOH A . G 6 HOH 645 2645 2645 HOH HOH A . G 6 HOH 646 2646 2646 HOH HOH A . G 6 HOH 647 2647 2647 HOH HOH A . G 6 HOH 648 2648 2648 HOH HOH A . G 6 HOH 649 2649 2649 HOH HOH A . G 6 HOH 650 2650 2650 HOH HOH A . G 6 HOH 651 2651 2651 HOH HOH A . G 6 HOH 652 2652 2652 HOH HOH A . G 6 HOH 653 2653 2653 HOH HOH A . G 6 HOH 654 2654 2654 HOH HOH A . G 6 HOH 655 2655 2655 HOH HOH A . G 6 HOH 656 2656 2656 HOH HOH A . G 6 HOH 657 2657 2657 HOH HOH A . G 6 HOH 658 2658 2658 HOH HOH A . G 6 HOH 659 2659 2659 HOH HOH A . G 6 HOH 660 2660 2660 HOH HOH A . G 6 HOH 661 2661 2661 HOH HOH A . G 6 HOH 662 2662 2662 HOH HOH A . G 6 HOH 663 2663 2663 HOH HOH A . G 6 HOH 664 2664 2664 HOH HOH A . G 6 HOH 665 2665 2665 HOH HOH A . G 6 HOH 666 2666 2666 HOH HOH A . G 6 HOH 667 2667 2667 HOH HOH A . G 6 HOH 668 2668 2668 HOH HOH A . G 6 HOH 669 2669 2669 HOH HOH A . G 6 HOH 670 2670 2670 HOH HOH A . G 6 HOH 671 2671 2671 HOH HOH A . G 6 HOH 672 2672 2672 HOH HOH A . G 6 HOH 673 2673 2673 HOH HOH A . G 6 HOH 674 2674 2674 HOH HOH A . G 6 HOH 675 2675 2675 HOH HOH A . G 6 HOH 676 2676 2676 HOH HOH A . G 6 HOH 677 2677 2677 HOH HOH A . G 6 HOH 678 2678 2678 HOH HOH A . G 6 HOH 679 2679 2679 HOH HOH A . G 6 HOH 680 2680 2680 HOH HOH A . G 6 HOH 681 2681 2681 HOH HOH A . G 6 HOH 682 2682 2682 HOH HOH A . G 6 HOH 683 2683 2683 HOH HOH A . G 6 HOH 684 2684 2684 HOH HOH A . G 6 HOH 685 2685 2685 HOH HOH A . G 6 HOH 686 2686 2686 HOH HOH A . G 6 HOH 687 2687 2687 HOH HOH A . G 6 HOH 688 2688 2688 HOH HOH A . G 6 HOH 689 2689 2689 HOH HOH A . G 6 HOH 690 2690 2690 HOH HOH A . G 6 HOH 691 2691 2691 HOH HOH A . G 6 HOH 692 2692 2692 HOH HOH A . G 6 HOH 693 2693 2693 HOH HOH A . G 6 HOH 694 2694 2694 HOH HOH A . G 6 HOH 695 2695 2695 HOH HOH A . G 6 HOH 696 2696 2696 HOH HOH A . G 6 HOH 697 2697 2697 HOH HOH A . G 6 HOH 698 2698 2698 HOH HOH A . G 6 HOH 699 2699 2699 HOH HOH A . G 6 HOH 700 2700 2700 HOH HOH A . G 6 HOH 701 2701 2701 HOH HOH A . G 6 HOH 702 2702 2702 HOH HOH A . G 6 HOH 703 2703 2703 HOH HOH A . G 6 HOH 704 2704 2704 HOH HOH A . G 6 HOH 705 2705 2705 HOH HOH A . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 36 A ASN 53 ? ASN 'GLYCOSYLATION SITE' 2 A ASN 294 A ASN 311 ? ASN 'GLYCOSYLATION SITE' # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_and_software_defined_assembly _pdbx_struct_assembly.method_details PISA _pdbx_struct_assembly.oligomeric_details monomeric _pdbx_struct_assembly.oligomeric_count 1 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # loop_ _pdbx_struct_conn_angle.id _pdbx_struct_conn_angle.ptnr1_label_atom_id _pdbx_struct_conn_angle.ptnr1_label_alt_id _pdbx_struct_conn_angle.ptnr1_label_asym_id _pdbx_struct_conn_angle.ptnr1_label_comp_id _pdbx_struct_conn_angle.ptnr1_label_seq_id _pdbx_struct_conn_angle.ptnr1_auth_atom_id _pdbx_struct_conn_angle.ptnr1_auth_asym_id _pdbx_struct_conn_angle.ptnr1_auth_comp_id _pdbx_struct_conn_angle.ptnr1_auth_seq_id _pdbx_struct_conn_angle.ptnr1_PDB_ins_code _pdbx_struct_conn_angle.ptnr1_symmetry _pdbx_struct_conn_angle.ptnr2_label_atom_id _pdbx_struct_conn_angle.ptnr2_label_alt_id _pdbx_struct_conn_angle.ptnr2_label_asym_id _pdbx_struct_conn_angle.ptnr2_label_comp_id _pdbx_struct_conn_angle.ptnr2_label_seq_id _pdbx_struct_conn_angle.ptnr2_auth_atom_id _pdbx_struct_conn_angle.ptnr2_auth_asym_id _pdbx_struct_conn_angle.ptnr2_auth_comp_id _pdbx_struct_conn_angle.ptnr2_auth_seq_id _pdbx_struct_conn_angle.ptnr2_PDB_ins_code _pdbx_struct_conn_angle.ptnr2_symmetry _pdbx_struct_conn_angle.ptnr3_label_atom_id _pdbx_struct_conn_angle.ptnr3_label_alt_id _pdbx_struct_conn_angle.ptnr3_label_asym_id _pdbx_struct_conn_angle.ptnr3_label_comp_id _pdbx_struct_conn_angle.ptnr3_label_seq_id _pdbx_struct_conn_angle.ptnr3_auth_atom_id _pdbx_struct_conn_angle.ptnr3_auth_asym_id _pdbx_struct_conn_angle.ptnr3_auth_comp_id _pdbx_struct_conn_angle.ptnr3_auth_seq_id _pdbx_struct_conn_angle.ptnr3_PDB_ins_code _pdbx_struct_conn_angle.ptnr3_symmetry _pdbx_struct_conn_angle.value _pdbx_struct_conn_angle.value_esd 1 O ? G HOH . ? A HOH 2527 ? 1_555 ZN ? C ZN . ? A ZN 1616 ? 1_555 NE2 ? A HIS 354 ? A HIS 371 ? 1_555 88.7 ? 2 O ? G HOH . ? A HOH 2527 ? 1_555 ZN ? C ZN . ? A ZN 1616 ? 1_555 OE1 ? A GLU 378 ? A GLU 395 ? 1_555 155.8 ? 3 NE2 ? A HIS 354 ? A HIS 371 ? 1_555 ZN ? C ZN . ? A ZN 1616 ? 1_555 OE1 ? A GLU 378 ? A GLU 395 ? 1_555 105.4 ? 4 O ? G HOH . ? A HOH 2527 ? 1_555 ZN ? C ZN . ? A ZN 1616 ? 1_555 NE2 ? A HIS 350 ? A HIS 367 ? 1_555 96.0 ? 5 NE2 ? A HIS 354 ? A HIS 371 ? 1_555 ZN ? C ZN . ? A ZN 1616 ? 1_555 NE2 ? A HIS 350 ? A HIS 367 ? 1_555 106.9 ? 6 OE1 ? A GLU 378 ? A GLU 395 ? 1_555 ZN ? C ZN . ? A ZN 1616 ? 1_555 NE2 ? A HIS 350 ? A HIS 367 ? 1_555 98.4 ? 7 O ? G HOH . ? A HOH 2527 ? 1_555 ZN ? C ZN . ? A ZN 1616 ? 1_555 O ? G HOH . ? A HOH 2528 ? 1_555 63.5 ? 8 NE2 ? A HIS 354 ? A HIS 371 ? 1_555 ZN ? C ZN . ? A ZN 1616 ? 1_555 O ? G HOH . ? A HOH 2528 ? 1_555 138.2 ? 9 OE1 ? A GLU 378 ? A GLU 395 ? 1_555 ZN ? C ZN . ? A ZN 1616 ? 1_555 O ? G HOH . ? A HOH 2528 ? 1_555 93.7 ? 10 NE2 ? A HIS 350 ? A HIS 367 ? 1_555 ZN ? C ZN . ? A ZN 1616 ? 1_555 O ? G HOH . ? A HOH 2528 ? 1_555 106.6 ? # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2015-08-26 2 'Structure model' 1 1 2015-09-30 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # _pdbx_audit_revision_group.ordinal 1 _pdbx_audit_revision_group.revision_ordinal 2 _pdbx_audit_revision_group.data_content_type 'Structure model' _pdbx_audit_revision_group.group 'Database references' # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal REFMAC refinement 5.8.0107 ? 1 MOSFLM 'data reduction' . ? 2 Aimless 'data scaling' . ? 3 PHASER phasing . ? 4 # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 ASN A 53 ? ? -167.75 90.49 2 1 ASP A 210 ? ? -160.37 107.51 3 1 LEU A 345 ? ? -112.18 -134.49 4 1 ASN A 572 ? ? -141.36 18.04 # _pdbx_distant_solvent_atoms.id 1 _pdbx_distant_solvent_atoms.PDB_model_num 1 _pdbx_distant_solvent_atoms.auth_atom_id O _pdbx_distant_solvent_atoms.label_alt_id ? _pdbx_distant_solvent_atoms.auth_asym_id A _pdbx_distant_solvent_atoms.auth_comp_id HOH _pdbx_distant_solvent_atoms.auth_seq_id 2147 _pdbx_distant_solvent_atoms.PDB_ins_code ? _pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 6.39 _pdbx_distant_solvent_atoms.neighbor_ligand_distance . # _pdbx_unobs_or_zero_occ_residues.id 1 _pdbx_unobs_or_zero_occ_residues.PDB_model_num 1 _pdbx_unobs_or_zero_occ_residues.polymer_flag Y _pdbx_unobs_or_zero_occ_residues.occupancy_flag 1 _pdbx_unobs_or_zero_occ_residues.auth_asym_id A _pdbx_unobs_or_zero_occ_residues.auth_comp_id SER _pdbx_unobs_or_zero_occ_residues.auth_seq_id 615 _pdbx_unobs_or_zero_occ_residues.PDB_ins_code ? _pdbx_unobs_or_zero_occ_residues.label_asym_id A _pdbx_unobs_or_zero_occ_residues.label_comp_id SER _pdbx_unobs_or_zero_occ_residues.label_seq_id 598 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 D-MALATE MLT 3 'ZINC ION' ZN 4 N-ACETYL-D-GLUCOSAMINE NAG 5 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL TRS 6 water HOH #