data_4ZCG # _entry.id 4ZCG # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.286 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 4ZCG WWPDB D_1000209036 # _pdbx_database_status.status_code REL _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.entry_id 4ZCG _pdbx_database_status.recvd_initial_deposition_date 2015-04-15 _pdbx_database_status.SG_entry N _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? _pdbx_database_status.pdb_format_compatible Y # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Terzyan, S.' 1 'Hanigan, M.' 2 # loop_ _citation.abstract _citation.abstract_id_CAS _citation.book_id_ISBN _citation.book_publisher _citation.book_publisher_city _citation.book_title _citation.coordinate_linkage _citation.country _citation.database_id_Medline _citation.details _citation.id _citation.journal_abbrev _citation.journal_id_ASTM _citation.journal_id_CSD _citation.journal_id_ISSN _citation.journal_full _citation.journal_issue _citation.journal_volume _citation.language _citation.page_first _citation.page_last _citation.title _citation.year _citation.database_id_CSD _citation.pdbx_database_id_DOI _citation.pdbx_database_id_PubMed _citation.unpublished_flag ? ? ? ? ? ? ? US ? ? primary J.Biol.Chem. JBCHA3 0071 1083-351X ? ? 290 ? 17576 17586 ;Human gamma-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. ; 2015 ? 10.1074/jbc.M115.659680 26013825 ? ? ? ? ? ? ? ? US ? ? 1 'J.Biol. Chem' JBCHA3 0071 0021-9258 ? ? 288 ? 31902 31913 'Novel insights into eukaryotic gamma-glutamyl transpeptidase 1 from the crystal structure of the glutamate-bound human enzyme.' 2014 ? ? 24047895 ? # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Terzyan, S.S.' 1 primary 'Burgett, A.W.' 2 primary 'Heroux, A.' 3 primary 'Smith, C.A.' 4 primary 'Mooers, B.H.' 5 primary 'Hanigan, M.H.' 6 1 'West, M.' 7 1 'Chen, Y.' 8 1 'Wickham, S.' 9 1 'Heroux, A.' 10 1 'Cahill, K.' 11 1 'Hanigan, M.' 12 1 'Mooers, B.' 13 # _cell.angle_alpha 90.000 _cell.angle_alpha_esd ? _cell.angle_beta 90.000 _cell.angle_beta_esd ? _cell.angle_gamma 90.000 _cell.angle_gamma_esd ? _cell.entry_id 4ZCG _cell.details ? _cell.formula_units_Z ? _cell.length_a 105.242 _cell.length_a_esd ? _cell.length_b 125.230 _cell.length_b_esd ? _cell.length_c 104.061 _cell.length_c_esd ? _cell.volume ? _cell.volume_esd ? _cell.Z_PDB 8 _cell.reciprocal_angle_alpha ? _cell.reciprocal_angle_beta ? _cell.reciprocal_angle_gamma ? _cell.reciprocal_angle_alpha_esd ? _cell.reciprocal_angle_beta_esd ? _cell.reciprocal_angle_gamma_esd ? _cell.reciprocal_length_a ? _cell.reciprocal_length_b ? _cell.reciprocal_length_c ? _cell.reciprocal_length_a_esd ? _cell.reciprocal_length_b_esd ? _cell.reciprocal_length_c_esd ? _cell.pdbx_unique_axis ? # _symmetry.entry_id 4ZCG _symmetry.cell_setting ? _symmetry.Int_Tables_number 20 _symmetry.space_group_name_Hall ? _symmetry.space_group_name_H-M 'C 2 2 21' _symmetry.pdbx_full_space_group_name_H-M ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'Gamma-glutamyltranspeptidase 1 heavy chain' 38533.664 1 2.3.2.2,3.4.19.13,3.4.19.14 ? 'Large subunit RESIDUES 28-380' ? 2 polymer man 'Gamma-glutamyltranspeptidase 1 light chain' 20014.438 1 2.3.2.2,3.4.19.13,3.4.19.14 ? 'Small subunit RESIDUES 381-569' ? 3 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 6 ? ? ? ? 4 non-polymer syn 'CHLORIDE ION' 35.453 2 ? ? ? ? 5 non-polymer syn 'SODIUM ION' 22.990 1 ? ? ? ? 6 non-polymer syn 'GLUTAMIC ACID' 147.129 1 ? ? ? ? 7 water nat water 18.015 428 ? ? ? ? # loop_ _entity_name_com.entity_id _entity_name_com.name 1 'GGT 1,Gamma-glutamyltransferase 1,Glutathione hydrolase 1,Leukotriene-C4 hydrolase' 2 'GGT 1,Gamma-glutamyltransferase 1,Glutathione hydrolase 1,Leukotriene-C4 hydrolase' # loop_ _entity_poly.entity_id _entity_poly.type _entity_poly.nstd_linkage _entity_poly.nstd_monomer _entity_poly.pdbx_seq_one_letter_code _entity_poly.pdbx_seq_one_letter_code_can _entity_poly.pdbx_strand_id _entity_poly.pdbx_target_identifier 1 'polypeptide(L)' no no ;SASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAR EVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQ QPVLCEVFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNI SLGDAVLYMPSAPLSGPVLALILNILKGYNFSRESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTS EFFAAQLRAQISDDTTHPISYYKPEFYTPDDGG ; ;SASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAR EVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQ QPVLCEVFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNI SLGDAVLYMPSAPLSGPVLALILNILKGYNFSRESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTS EFFAAQLRAQISDDTTHPISYYKPEFYTPDDGG ; A ? 2 'polypeptide(L)' no no ;TAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVG QDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTF IAVVQAIVRTAGGWAAASDSRKGGEPAGY ; ;TAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVG QDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTF IAVVQAIVRTAGGWAAASDSRKGGEPAGY ; B ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 SER n 1 2 ALA n 1 3 SER n 1 4 LYS n 1 5 GLU n 1 6 PRO n 1 7 ASP n 1 8 ASN n 1 9 HIS n 1 10 VAL n 1 11 TYR n 1 12 THR n 1 13 ARG n 1 14 ALA n 1 15 ALA n 1 16 VAL n 1 17 ALA n 1 18 ALA n 1 19 ASP n 1 20 ALA n 1 21 LYS n 1 22 GLN n 1 23 CYS n 1 24 SER n 1 25 LYS n 1 26 ILE n 1 27 GLY n 1 28 ARG n 1 29 ASP n 1 30 ALA n 1 31 LEU n 1 32 ARG n 1 33 ASP n 1 34 GLY n 1 35 GLY n 1 36 SER n 1 37 ALA n 1 38 VAL n 1 39 ASP n 1 40 ALA n 1 41 ALA n 1 42 ILE n 1 43 ALA n 1 44 ALA n 1 45 LEU n 1 46 LEU n 1 47 CYS n 1 48 VAL n 1 49 GLY n 1 50 LEU n 1 51 MET n 1 52 ASN n 1 53 ALA n 1 54 HIS n 1 55 SER n 1 56 MET n 1 57 GLY n 1 58 ILE n 1 59 GLY n 1 60 GLY n 1 61 GLY n 1 62 LEU n 1 63 PHE n 1 64 LEU n 1 65 THR n 1 66 ILE n 1 67 TYR n 1 68 ASN n 1 69 SER n 1 70 THR n 1 71 THR n 1 72 ARG n 1 73 LYS n 1 74 ALA n 1 75 GLU n 1 76 VAL n 1 77 ILE n 1 78 ASN n 1 79 ALA n 1 80 ARG n 1 81 GLU n 1 82 VAL n 1 83 ALA n 1 84 PRO n 1 85 ARG n 1 86 LEU n 1 87 ALA n 1 88 PHE n 1 89 ALA n 1 90 THR n 1 91 MET n 1 92 PHE n 1 93 ASN n 1 94 SER n 1 95 SER n 1 96 GLU n 1 97 GLN n 1 98 SER n 1 99 GLN n 1 100 LYS n 1 101 GLY n 1 102 GLY n 1 103 LEU n 1 104 SER n 1 105 VAL n 1 106 ALA n 1 107 VAL n 1 108 PRO n 1 109 GLY n 1 110 GLU n 1 111 ILE n 1 112 ARG n 1 113 GLY n 1 114 TYR n 1 115 GLU n 1 116 LEU n 1 117 ALA n 1 118 HIS n 1 119 GLN n 1 120 ARG n 1 121 HIS n 1 122 GLY n 1 123 ARG n 1 124 LEU n 1 125 PRO n 1 126 TRP n 1 127 ALA n 1 128 ARG n 1 129 LEU n 1 130 PHE n 1 131 GLN n 1 132 PRO n 1 133 SER n 1 134 ILE n 1 135 GLN n 1 136 LEU n 1 137 ALA n 1 138 ARG n 1 139 GLN n 1 140 GLY n 1 141 PHE n 1 142 PRO n 1 143 VAL n 1 144 GLY n 1 145 LYS n 1 146 GLY n 1 147 LEU n 1 148 ALA n 1 149 ALA n 1 150 ALA n 1 151 LEU n 1 152 GLU n 1 153 ASN n 1 154 LYS n 1 155 ARG n 1 156 THR n 1 157 VAL n 1 158 ILE n 1 159 GLU n 1 160 GLN n 1 161 GLN n 1 162 PRO n 1 163 VAL n 1 164 LEU n 1 165 CYS n 1 166 GLU n 1 167 VAL n 1 168 PHE n 1 169 CYS n 1 170 ARG n 1 171 ASP n 1 172 ARG n 1 173 LYS n 1 174 VAL n 1 175 LEU n 1 176 ARG n 1 177 GLU n 1 178 GLY n 1 179 GLU n 1 180 ARG n 1 181 LEU n 1 182 THR n 1 183 LEU n 1 184 PRO n 1 185 GLN n 1 186 LEU n 1 187 ALA n 1 188 ASP n 1 189 THR n 1 190 TYR n 1 191 GLU n 1 192 THR n 1 193 LEU n 1 194 ALA n 1 195 ILE n 1 196 GLU n 1 197 GLY n 1 198 ALA n 1 199 GLN n 1 200 ALA n 1 201 PHE n 1 202 TYR n 1 203 ASN n 1 204 GLY n 1 205 SER n 1 206 LEU n 1 207 THR n 1 208 ALA n 1 209 GLN n 1 210 ILE n 1 211 VAL n 1 212 LYS n 1 213 ASP n 1 214 ILE n 1 215 GLN n 1 216 ALA n 1 217 ALA n 1 218 GLY n 1 219 GLY n 1 220 ILE n 1 221 VAL n 1 222 THR n 1 223 ALA n 1 224 GLU n 1 225 ASP n 1 226 LEU n 1 227 ASN n 1 228 ASN n 1 229 TYR n 1 230 ARG n 1 231 ALA n 1 232 GLU n 1 233 LEU n 1 234 ILE n 1 235 GLU n 1 236 HIS n 1 237 PRO n 1 238 LEU n 1 239 ASN n 1 240 ILE n 1 241 SER n 1 242 LEU n 1 243 GLY n 1 244 ASP n 1 245 ALA n 1 246 VAL n 1 247 LEU n 1 248 TYR n 1 249 MET n 1 250 PRO n 1 251 SER n 1 252 ALA n 1 253 PRO n 1 254 LEU n 1 255 SER n 1 256 GLY n 1 257 PRO n 1 258 VAL n 1 259 LEU n 1 260 ALA n 1 261 LEU n 1 262 ILE n 1 263 LEU n 1 264 ASN n 1 265 ILE n 1 266 LEU n 1 267 LYS n 1 268 GLY n 1 269 TYR n 1 270 ASN n 1 271 PHE n 1 272 SER n 1 273 ARG n 1 274 GLU n 1 275 SER n 1 276 VAL n 1 277 GLU n 1 278 SER n 1 279 PRO n 1 280 GLU n 1 281 GLN n 1 282 LYS n 1 283 GLY n 1 284 LEU n 1 285 THR n 1 286 TYR n 1 287 HIS n 1 288 ARG n 1 289 ILE n 1 290 VAL n 1 291 GLU n 1 292 ALA n 1 293 PHE n 1 294 ARG n 1 295 PHE n 1 296 ALA n 1 297 TYR n 1 298 ALA n 1 299 LYS n 1 300 ARG n 1 301 THR n 1 302 LEU n 1 303 LEU n 1 304 GLY n 1 305 ASP n 1 306 PRO n 1 307 LYS n 1 308 PHE n 1 309 VAL n 1 310 ASP n 1 311 VAL n 1 312 THR n 1 313 GLU n 1 314 VAL n 1 315 VAL n 1 316 ARG n 1 317 ASN n 1 318 MET n 1 319 THR n 1 320 SER n 1 321 GLU n 1 322 PHE n 1 323 PHE n 1 324 ALA n 1 325 ALA n 1 326 GLN n 1 327 LEU n 1 328 ARG n 1 329 ALA n 1 330 GLN n 1 331 ILE n 1 332 SER n 1 333 ASP n 1 334 ASP n 1 335 THR n 1 336 THR n 1 337 HIS n 1 338 PRO n 1 339 ILE n 1 340 SER n 1 341 TYR n 1 342 TYR n 1 343 LYS n 1 344 PRO n 1 345 GLU n 1 346 PHE n 1 347 TYR n 1 348 THR n 1 349 PRO n 1 350 ASP n 1 351 ASP n 1 352 GLY n 1 353 GLY n 2 1 THR n 2 2 ALA n 2 3 HIS n 2 4 LEU n 2 5 SER n 2 6 VAL n 2 7 VAL n 2 8 ALA n 2 9 GLU n 2 10 ASP n 2 11 GLY n 2 12 SER n 2 13 ALA n 2 14 VAL n 2 15 SER n 2 16 ALA n 2 17 THR n 2 18 SER n 2 19 THR n 2 20 ILE n 2 21 ASN n 2 22 LEU n 2 23 TYR n 2 24 PHE n 2 25 GLY n 2 26 SER n 2 27 LYS n 2 28 VAL n 2 29 ARG n 2 30 SER n 2 31 PRO n 2 32 VAL n 2 33 SER n 2 34 GLY n 2 35 ILE n 2 36 LEU n 2 37 PHE n 2 38 ASN n 2 39 ASN n 2 40 GLU n 2 41 MET n 2 42 ASP n 2 43 ASP n 2 44 PHE n 2 45 SER n 2 46 SER n 2 47 PRO n 2 48 SER n 2 49 ILE n 2 50 THR n 2 51 ASN n 2 52 GLU n 2 53 PHE n 2 54 GLY n 2 55 VAL n 2 56 PRO n 2 57 PRO n 2 58 SER n 2 59 PRO n 2 60 ALA n 2 61 ASN n 2 62 PHE n 2 63 ILE n 2 64 GLN n 2 65 PRO n 2 66 GLY n 2 67 LYS n 2 68 GLN n 2 69 PRO n 2 70 LEU n 2 71 SER n 2 72 SER n 2 73 MET n 2 74 CYS n 2 75 PRO n 2 76 THR n 2 77 ILE n 2 78 MET n 2 79 VAL n 2 80 GLY n 2 81 GLN n 2 82 ASP n 2 83 GLY n 2 84 GLN n 2 85 VAL n 2 86 ARG n 2 87 MET n 2 88 VAL n 2 89 VAL n 2 90 GLY n 2 91 ALA n 2 92 ALA n 2 93 GLY n 2 94 GLY n 2 95 THR n 2 96 GLN n 2 97 ILE n 2 98 THR n 2 99 THR n 2 100 ALA n 2 101 THR n 2 102 ALA n 2 103 LEU n 2 104 ALA n 2 105 ILE n 2 106 ILE n 2 107 TYR n 2 108 ASN n 2 109 LEU n 2 110 TRP n 2 111 PHE n 2 112 GLY n 2 113 TYR n 2 114 ASP n 2 115 VAL n 2 116 LYS n 2 117 ARG n 2 118 ALA n 2 119 VAL n 2 120 GLU n 2 121 GLU n 2 122 PRO n 2 123 ARG n 2 124 LEU n 2 125 HIS n 2 126 ASN n 2 127 GLN n 2 128 LEU n 2 129 LEU n 2 130 PRO n 2 131 ASN n 2 132 VAL n 2 133 THR n 2 134 THR n 2 135 VAL n 2 136 GLU n 2 137 ARG n 2 138 ASN n 2 139 ILE n 2 140 ASP n 2 141 GLN n 2 142 ALA n 2 143 VAL n 2 144 THR n 2 145 ALA n 2 146 ALA n 2 147 LEU n 2 148 GLU n 2 149 THR n 2 150 ARG n 2 151 HIS n 2 152 HIS n 2 153 HIS n 2 154 THR n 2 155 GLN n 2 156 ILE n 2 157 ALA n 2 158 SER n 2 159 THR n 2 160 PHE n 2 161 ILE n 2 162 ALA n 2 163 VAL n 2 164 VAL n 2 165 GLN n 2 166 ALA n 2 167 ILE n 2 168 VAL n 2 169 ARG n 2 170 THR n 2 171 ALA n 2 172 GLY n 2 173 GLY n 2 174 TRP n 2 175 ALA n 2 176 ALA n 2 177 ALA n 2 178 SER n 2 179 ASP n 2 180 SER n 2 181 ARG n 2 182 LYS n 2 183 GLY n 2 184 GLY n 2 185 GLU n 2 186 PRO n 2 187 ALA n 2 188 GLY n 2 189 TYR n # loop_ _entity_src_gen.entity_id _entity_src_gen.pdbx_src_id _entity_src_gen.pdbx_alt_source_flag _entity_src_gen.pdbx_seq_type _entity_src_gen.pdbx_beg_seq_num _entity_src_gen.pdbx_end_seq_num _entity_src_gen.gene_src_common_name _entity_src_gen.gene_src_genus _entity_src_gen.pdbx_gene_src_gene _entity_src_gen.gene_src_species _entity_src_gen.gene_src_strain _entity_src_gen.gene_src_tissue _entity_src_gen.gene_src_tissue_fraction _entity_src_gen.gene_src_details _entity_src_gen.pdbx_gene_src_fragment _entity_src_gen.pdbx_gene_src_scientific_name _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id _entity_src_gen.pdbx_gene_src_variant _entity_src_gen.pdbx_gene_src_cell_line _entity_src_gen.pdbx_gene_src_atcc _entity_src_gen.pdbx_gene_src_organ _entity_src_gen.pdbx_gene_src_organelle _entity_src_gen.pdbx_gene_src_cell _entity_src_gen.pdbx_gene_src_cellular_location _entity_src_gen.host_org_common_name _entity_src_gen.pdbx_host_org_scientific_name _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id _entity_src_gen.host_org_genus _entity_src_gen.pdbx_host_org_gene _entity_src_gen.pdbx_host_org_organ _entity_src_gen.host_org_species _entity_src_gen.pdbx_host_org_tissue _entity_src_gen.pdbx_host_org_tissue_fraction _entity_src_gen.pdbx_host_org_strain _entity_src_gen.pdbx_host_org_variant _entity_src_gen.pdbx_host_org_cell_line _entity_src_gen.pdbx_host_org_atcc _entity_src_gen.pdbx_host_org_culture_collection _entity_src_gen.pdbx_host_org_cell _entity_src_gen.pdbx_host_org_organelle _entity_src_gen.pdbx_host_org_cellular_location _entity_src_gen.pdbx_host_org_vector_type _entity_src_gen.pdbx_host_org_vector _entity_src_gen.host_org_details _entity_src_gen.expression_system_id _entity_src_gen.plasmid_name _entity_src_gen.plasmid_details _entity_src_gen.pdbx_description 1 1 sample 'Biological sequence' 1 353 Human ? 'GGT1, GGT' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? PICHIA 4919 ? ? ? ? ? ? X-33 ? ? ? ? ? ? ? plasmid ? ? ? pPICZaA ? ? 2 1 sample 'Biological sequence' 1 189 Human ? 'GGT1, GGT' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? PICHIA 4919 ? ? ? ? ? ? X-33 ? ? ? ? ? ? ? plazmid ? ? ? pPICZaA ? ? # loop_ _struct_ref.id _struct_ref.db_name _struct_ref.db_code _struct_ref.pdbx_db_accession _struct_ref.pdbx_db_isoform _struct_ref.entity_id _struct_ref.pdbx_seq_one_letter_code _struct_ref.pdbx_align_begin 1 UNP GGT1_HUMAN P19440 ? 1 ;SASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAR EVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQ QPVLCEVFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNI SLGDVVLYMPSAPLSGPVLALILNILKGYNFSRESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTS EFFAAQLRAQISDDTTHPISYYKPEFYTPDDGG ; 28 2 UNP GGT1_HUMAN P19440 ? 2 ;TAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVG QDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTF IAVVQAIVRTAGGWAAASDSRKGGEPAGY ; 381 # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 4ZCG A 1 ? 353 ? P19440 28 ? 380 ? 28 380 2 2 4ZCG B 1 ? 189 ? P19440 381 ? 569 ? 381 569 # _struct_ref_seq_dif.align_id 1 _struct_ref_seq_dif.pdbx_pdb_id_code 4ZCG _struct_ref_seq_dif.mon_id ALA _struct_ref_seq_dif.pdbx_pdb_strand_id A _struct_ref_seq_dif.seq_num 245 _struct_ref_seq_dif.pdbx_pdb_ins_code ? _struct_ref_seq_dif.pdbx_seq_db_name UNP _struct_ref_seq_dif.pdbx_seq_db_accession_code P19440 _struct_ref_seq_dif.db_mon_id VAL _struct_ref_seq_dif.pdbx_seq_db_seq_num 272 _struct_ref_seq_dif.details VARIANT _struct_ref_seq_dif.pdbx_auth_seq_num 272 _struct_ref_seq_dif.pdbx_ordinal 1 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CL non-polymer . 'CHLORIDE ION' ? 'Cl -1' 35.453 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NA non-polymer . 'SODIUM ION' ? 'Na 1' 22.990 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.absorpt_coefficient_mu ? _exptl.absorpt_correction_T_max ? _exptl.absorpt_correction_T_min ? _exptl.absorpt_correction_type ? _exptl.absorpt_process_details ? _exptl.entry_id 4ZCG _exptl.crystals_number 1 _exptl.details ? _exptl.method 'X-RAY DIFFRACTION' _exptl.method_details ? # _exptl_crystal.colour ? _exptl_crystal.density_diffrn ? _exptl_crystal.density_Matthews 2.93 _exptl_crystal.density_method ? _exptl_crystal.density_percent_sol 57.99 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.id 1 _exptl_crystal.preparation ? _exptl_crystal.size_max ? _exptl_crystal.size_mid ? _exptl_crystal.size_min ? _exptl_crystal.size_rad ? _exptl_crystal.colour_lustre ? _exptl_crystal.colour_modifier ? _exptl_crystal.colour_primary ? _exptl_crystal.density_meas ? _exptl_crystal.density_meas_esd ? _exptl_crystal.density_meas_gt ? _exptl_crystal.density_meas_lt ? _exptl_crystal.density_meas_temp ? _exptl_crystal.density_meas_temp_esd ? _exptl_crystal.density_meas_temp_gt ? _exptl_crystal.density_meas_temp_lt ? _exptl_crystal.pdbx_crystal_image_url ? _exptl_crystal.pdbx_crystal_image_format ? _exptl_crystal.pdbx_mosaicity ? _exptl_crystal.pdbx_mosaicity_esd ? # _exptl_crystal_grow.apparatus ? _exptl_crystal_grow.atmosphere ? _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.details ? _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.method_ref ? _exptl_crystal_grow.pH 6.0 _exptl_crystal_grow.pressure ? _exptl_crystal_grow.pressure_esd ? _exptl_crystal_grow.seeding ? _exptl_crystal_grow.seeding_ref ? _exptl_crystal_grow.temp 298 _exptl_crystal_grow.temp_details 'Room Temperature' _exptl_crystal_grow.temp_esd ? _exptl_crystal_grow.time ? _exptl_crystal_grow.pdbx_details 'PEG3350, NH4Cl' _exptl_crystal_grow.pdbx_pH_range 6.0-6.3 # _diffrn.ambient_environment ? _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.ambient_temp_esd ? _diffrn.crystal_id 1 _diffrn.crystal_support ? _diffrn.crystal_treatment ? _diffrn.details ? _diffrn.id 1 _diffrn.ambient_pressure ? _diffrn.ambient_pressure_esd ? _diffrn.ambient_pressure_gt ? _diffrn.ambient_pressure_lt ? _diffrn.ambient_temp_gt ? _diffrn.ambient_temp_lt ? # _diffrn_detector.details mirrors _diffrn_detector.detector PIXEL _diffrn_detector.diffrn_id 1 _diffrn_detector.type 'DECTRIS PILATUS 6M' _diffrn_detector.area_resol_mean ? _diffrn_detector.dtime ? _diffrn_detector.pdbx_frames_total ? _diffrn_detector.pdbx_collection_time_total ? _diffrn_detector.pdbx_collection_date 2013-08-15 # _diffrn_radiation.collimation ? _diffrn_radiation.diffrn_id 1 _diffrn_radiation.filter_edge ? _diffrn_radiation.inhomogeneity ? _diffrn_radiation.monochromator 'Si 111 doble crystal' _diffrn_radiation.polarisn_norm ? _diffrn_radiation.polarisn_ratio ? _diffrn_radiation.probe ? _diffrn_radiation.type ? _diffrn_radiation.xray_symbol ? _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.pdbx_wavelength_list ? _diffrn_radiation.pdbx_wavelength ? _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_analyzer ? _diffrn_radiation.pdbx_scattering_type x-ray # loop_ _diffrn_radiation_wavelength.id _diffrn_radiation_wavelength.wavelength _diffrn_radiation_wavelength.wt 1 1.1000 1.0 2 1.1 1.0 # _diffrn_source.current ? _diffrn_source.details ? _diffrn_source.diffrn_id 1 _diffrn_source.power ? _diffrn_source.size ? _diffrn_source.source SYNCHROTRON _diffrn_source.target ? _diffrn_source.type 'NSLS BEAMLINE X25' _diffrn_source.voltage ? _diffrn_source.take-off_angle ? _diffrn_source.pdbx_wavelength_list 1.1 _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_synchrotron_beamline X25 _diffrn_source.pdbx_synchrotron_site NSLS # _reflns.B_iso_Wilson_estimate 23.09 _reflns.entry_id 4ZCG _reflns.data_reduction_details ? _reflns.data_reduction_method ? _reflns.d_resolution_high 2.100 _reflns.d_resolution_low 50.000 _reflns.details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.number_all ? _reflns.number_obs 37862 _reflns.observed_criterion ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.observed_criterion_I_max ? _reflns.observed_criterion_I_min ? _reflns.observed_criterion_sigma_F ? _reflns.observed_criterion_sigma_I -3 _reflns.percent_possible_obs 93.000 _reflns.R_free_details ? _reflns.Rmerge_F_all ? _reflns.Rmerge_F_obs ? _reflns.Friedel_coverage ? _reflns.number_gt ? _reflns.threshold_expression ? _reflns.pdbx_redundancy 10.400 _reflns.pdbx_Rmerge_I_obs 0.095 _reflns.pdbx_Rmerge_I_all ? _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_av_sigmaI 21.923 _reflns.pdbx_netI_over_sigmaI 9.600 _reflns.pdbx_res_netI_over_av_sigmaI_2 ? _reflns.pdbx_res_netI_over_sigmaI_2 ? _reflns.pdbx_chi_squared 1.048 _reflns.pdbx_scaling_rejects ? _reflns.pdbx_d_res_high_opt ? _reflns.pdbx_d_res_low_opt ? _reflns.pdbx_d_res_opt_method ? _reflns.phase_calculation_details ? _reflns.pdbx_Rrim_I_all 0.100 _reflns.pdbx_Rpim_I_all 0.029 _reflns.pdbx_d_opt ? _reflns.pdbx_number_measured_all 391920 _reflns.pdbx_diffrn_id 1 _reflns.pdbx_ordinal 1 _reflns.pdbx_CC_half ? _reflns.pdbx_R_split ? # loop_ _reflns_shell.d_res_high _reflns_shell.d_res_low _reflns_shell.meanI_over_sigI_all _reflns_shell.meanI_over_sigI_obs _reflns_shell.number_measured_all _reflns_shell.number_measured_obs _reflns_shell.number_possible _reflns_shell.number_unique_all _reflns_shell.number_unique_obs _reflns_shell.percent_possible_all _reflns_shell.percent_possible_obs _reflns_shell.Rmerge_F_all _reflns_shell.Rmerge_F_obs _reflns_shell.Rmerge_I_all _reflns_shell.Rmerge_I_obs _reflns_shell.meanI_over_sigI_gt _reflns_shell.meanI_over_uI_all _reflns_shell.meanI_over_uI_gt _reflns_shell.number_measured_gt _reflns_shell.number_unique_gt _reflns_shell.percent_possible_gt _reflns_shell.Rmerge_F_gt _reflns_shell.Rmerge_I_gt _reflns_shell.pdbx_redundancy _reflns_shell.pdbx_Rsym_value _reflns_shell.pdbx_chi_squared _reflns_shell.pdbx_netI_over_sigmaI_all _reflns_shell.pdbx_netI_over_sigmaI_obs _reflns_shell.pdbx_Rrim_I_all _reflns_shell.pdbx_Rpim_I_all _reflns_shell.pdbx_rejects _reflns_shell.pdbx_ordinal _reflns_shell.pdbx_diffrn_id _reflns_shell.pdbx_CC_half _reflns_shell.pdbx_R_split 2.100 2.140 ? ? ? ? ? 1046 ? 52.400 ? ? ? ? 0.452 ? ? ? ? ? ? ? ? 2.600 ? 1.041 ? ? 0.542 0.291 0 1 1 0.799 ? 2.140 2.180 ? ? ? ? ? 1289 ? 63.900 ? ? ? ? 0.466 ? ? ? ? ? ? ? ? 3.200 ? 0.976 ? ? 0.544 0.272 0 2 1 0.804 ? 2.180 2.220 ? ? ? ? ? 1456 ? 71.700 ? ? ? ? 0.440 ? ? ? ? ? ? ? ? 4.100 ? 1.020 ? ? 0.500 0.231 0 3 1 0.862 ? 2.220 2.260 ? ? ? ? ? 1661 ? 83.700 ? ? ? ? 0.421 ? ? ? ? ? ? ? ? 4.800 ? 1.042 ? ? 0.471 0.203 0 4 1 0.878 ? 2.260 2.310 ? ? ? ? ? 1808 ? 90.000 ? ? ? ? 0.389 ? ? ? ? ? ? ? ? 5.800 ? 1.062 ? ? 0.428 0.172 0 5 1 0.906 ? 2.310 2.370 ? ? ? ? ? 1950 ? 96.200 ? ? ? ? 0.363 ? ? ? ? ? ? ? ? 6.900 ? 1.085 ? ? 0.394 0.147 0 6 1 0.925 ? 2.370 2.420 ? ? ? ? ? 2012 ? 99.500 ? ? ? ? 0.319 ? ? ? ? ? ? ? ? 8.400 ? 1.051 ? ? 0.340 0.115 0 7 1 0.959 ? 2.420 2.490 ? ? ? ? ? 2009 ? 100.000 ? ? ? ? 0.308 ? ? ? ? ? ? ? ? 10.300 ? 0.998 ? ? 0.324 0.101 0 8 1 0.975 ? 2.490 2.560 ? ? ? ? ? 2019 ? 100.000 ? ? ? ? 0.261 ? ? ? ? ? ? ? ? 11.300 ? 1.031 ? ? 0.274 0.081 0 9 1 0.980 ? 2.560 2.650 ? ? ? ? ? 2036 ? 100.000 ? ? ? ? 0.227 ? ? ? ? ? ? ? ? 12.900 ? 1.022 ? ? 0.236 0.065 0 10 1 0.988 ? 2.650 2.740 ? ? ? ? ? 2020 ? 100.000 ? ? ? ? 0.186 ? ? ? ? ? ? ? ? 12.800 ? 1.053 ? ? 0.194 0.054 0 11 1 0.990 ? 2.740 2.850 ? ? ? ? ? 2019 ? 100.000 ? ? ? ? 0.162 ? ? ? ? ? ? ? ? 12.500 ? 1.068 ? ? 0.169 0.048 0 12 1 0.992 ? 2.850 2.980 ? ? ? ? ? 2020 ? 100.000 ? ? ? ? 0.138 ? ? ? ? ? ? ? ? 12.900 ? 1.073 ? ? 0.144 0.040 0 13 1 0.994 ? 2.980 3.140 ? ? ? ? ? 2040 ? 100.000 ? ? ? ? 0.119 ? ? ? ? ? ? ? ? 12.800 ? 1.077 ? ? 0.124 0.034 0 14 1 0.996 ? 3.140 3.330 ? ? ? ? ? 2041 ? 100.000 ? ? ? ? 0.098 ? ? ? ? ? ? ? ? 12.800 ? 1.079 ? ? 0.102 0.028 0 15 1 0.997 ? 3.330 3.590 ? ? ? ? ? 2051 ? 100.000 ? ? ? ? 0.083 ? ? ? ? ? ? ? ? 12.600 ? 1.090 ? ? 0.086 0.024 0 16 1 0.997 ? 3.590 3.950 ? ? ? ? ? 2037 ? 100.000 ? ? ? ? 0.068 ? ? ? ? ? ? ? ? 12.700 ? 1.082 ? ? 0.071 0.020 0 17 1 0.998 ? 3.950 4.520 ? ? ? ? ? 2086 ? 100.000 ? ? ? ? 0.060 ? ? ? ? ? ? ? ? 12.600 ? 0.999 ? ? 0.063 0.018 0 18 1 0.997 ? 4.520 5.700 ? ? ? ? ? 2083 ? 100.000 ? ? ? ? 0.059 ? ? ? ? ? ? ? ? 12.800 ? 1.017 ? ? 0.062 0.017 0 19 1 0.999 ? 5.700 50.000 ? ? ? ? ? 2179 ? 100.000 ? ? ? ? 0.055 ? ? ? ? ? ? ? ? 12.100 ? 1.012 ? ? 0.058 0.016 0 20 1 0.999 ? # _refine.aniso_B[1][1] -0.0000 _refine.aniso_B[1][2] -0.0000 _refine.aniso_B[1][3] 0.0000 _refine.aniso_B[2][2] 0.0300 _refine.aniso_B[2][3] -0.0000 _refine.aniso_B[3][3] -0.0200 _refine.B_iso_max 121.420 _refine.B_iso_mean 35.0530 _refine.B_iso_min 17.700 _refine.correlation_coeff_Fo_to_Fc 0.9690 _refine.correlation_coeff_Fo_to_Fc_free 0.9560 _refine.details 'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY' _refine.diff_density_max ? _refine.diff_density_max_esd ? _refine.diff_density_min ? _refine.diff_density_min_esd ? _refine.diff_density_rms ? _refine.diff_density_rms_esd ? _refine.entry_id 4ZCG _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.ls_abs_structure_details ? _refine.ls_abs_structure_Flack ? _refine.ls_abs_structure_Flack_esd ? _refine.ls_abs_structure_Rogers ? _refine.ls_abs_structure_Rogers_esd ? _refine.ls_d_res_high 2.2200 _refine.ls_d_res_low 40.0200 _refine.ls_extinction_coef ? _refine.ls_extinction_coef_esd ? _refine.ls_extinction_expression ? _refine.ls_extinction_method ? _refine.ls_goodness_of_fit_all ? _refine.ls_goodness_of_fit_all_esd ? _refine.ls_goodness_of_fit_obs ? _refine.ls_goodness_of_fit_obs_esd ? _refine.ls_hydrogen_treatment ? _refine.ls_matrix_type ? _refine.ls_number_constraints ? _refine.ls_number_parameters ? _refine.ls_number_reflns_all ? _refine.ls_number_reflns_obs 32064 _refine.ls_number_reflns_R_free 1704 _refine.ls_number_reflns_R_work ? _refine.ls_number_restraints ? _refine.ls_percent_reflns_obs 98.4300 _refine.ls_percent_reflns_R_free 5.0000 _refine.ls_R_factor_all ? _refine.ls_R_factor_obs 0.1483 _refine.ls_R_factor_R_free 0.1852 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_R_factor_R_work 0.1463 _refine.ls_R_Fsqd_factor_obs ? _refine.ls_R_I_factor_obs ? _refine.ls_redundancy_reflns_all ? _refine.ls_redundancy_reflns_obs ? _refine.ls_restrained_S_all ? _refine.ls_restrained_S_obs ? _refine.ls_shift_over_esd_max ? _refine.ls_shift_over_esd_mean ? _refine.ls_structure_factor_coef ? _refine.ls_weighting_details ? _refine.ls_weighting_scheme ? _refine.ls_wR_factor_all ? _refine.ls_wR_factor_obs ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.occupancy_max ? _refine.occupancy_min ? _refine.solvent_model_details MASK _refine.solvent_model_param_bsol ? _refine.solvent_model_param_ksol ? _refine.ls_R_factor_gt ? _refine.ls_goodness_of_fit_gt ? _refine.ls_goodness_of_fit_ref ? _refine.ls_shift_over_su_max ? _refine.ls_shift_over_su_max_lt ? _refine.ls_shift_over_su_mean ? _refine.ls_shift_over_su_mean_lt ? _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F 0.000 _refine.pdbx_ls_sigma_Fsqd ? _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.pdbx_method_to_determine_struct 'FOURIER SYNTHESIS' _refine.pdbx_starting_model 4GDX _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_overall_ESU_R 0.1940 _refine.pdbx_overall_ESU_R_Free 0.1600 _refine.pdbx_solvent_vdw_probe_radii 1.2000 _refine.pdbx_solvent_ion_probe_radii 0.8000 _refine.pdbx_solvent_shrinkage_radii 0.8000 _refine.pdbx_real_space_R ? _refine.pdbx_density_correlation ? _refine.pdbx_pd_number_of_powder_patterns ? _refine.pdbx_pd_number_of_points ? _refine.pdbx_pd_meas_number_of_points ? _refine.pdbx_pd_proc_ls_prof_R_factor ? _refine.pdbx_pd_proc_ls_prof_wR_factor ? _refine.pdbx_pd_Marquardt_correlation_coeff ? _refine.pdbx_pd_Fsqrd_R_factor ? _refine.pdbx_pd_ls_matrix_band_width ? _refine.pdbx_overall_phase_error ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_diffrn_id 1 _refine.overall_SU_B 4.3030 _refine.overall_SU_ML 0.1060 _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_average_fsc_overall ? _refine.pdbx_average_fsc_work ? _refine.pdbx_average_fsc_free ? # _refine_hist.cycle_id final _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.d_res_high 2.2200 _refine_hist.d_res_low 40.0200 _refine_hist.pdbx_number_atoms_ligand 97 _refine_hist.number_atoms_solvent 428 _refine_hist.number_atoms_total 4571 _refine_hist.pdbx_number_residues_total 531 _refine_hist.pdbx_B_iso_mean_ligand 61.94 _refine_hist.pdbx_B_iso_mean_solvent 44.77 _refine_hist.pdbx_number_atoms_protein 4046 _refine_hist.pdbx_number_atoms_nucleic_acid 0 # loop_ _refine_ls_restr.pdbx_refine_id _refine_ls_restr.criterion _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.number _refine_ls_restr.rejects _refine_ls_restr.type _refine_ls_restr.weight _refine_ls_restr.pdbx_restraint_function 'X-RAY DIFFRACTION' ? 0.011 0.019 4290 ? r_bond_refined_d ? ? 'X-RAY DIFFRACTION' ? 0.001 0.020 4082 ? r_bond_other_d ? ? 'X-RAY DIFFRACTION' ? 1.411 1.976 5850 ? r_angle_refined_deg ? ? 'X-RAY DIFFRACTION' ? 0.778 3.000 9351 ? r_angle_other_deg ? ? 'X-RAY DIFFRACTION' ? 5.948 5.000 550 ? r_dihedral_angle_1_deg ? ? 'X-RAY DIFFRACTION' ? 36.172 23.690 187 ? r_dihedral_angle_2_deg ? ? 'X-RAY DIFFRACTION' ? 14.231 15.000 684 ? r_dihedral_angle_3_deg ? ? 'X-RAY DIFFRACTION' ? 13.656 15.000 32 ? r_dihedral_angle_4_deg ? ? 'X-RAY DIFFRACTION' ? 0.078 0.200 677 ? r_chiral_restr ? ? 'X-RAY DIFFRACTION' ? 0.006 0.021 4905 ? r_gen_planes_refined ? ? 'X-RAY DIFFRACTION' ? 0.001 0.020 981 ? r_gen_planes_other ? ? 'X-RAY DIFFRACTION' ? 2.113 3.182 2147 ? r_mcbond_it ? ? 'X-RAY DIFFRACTION' ? 2.112 3.182 2146 ? r_mcbond_other ? ? 'X-RAY DIFFRACTION' ? 3.362 4.762 2684 ? r_mcangle_it ? ? # _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_ls_shell.d_res_high 2.2200 _refine_ls_shell.d_res_low 2.2780 _refine_ls_shell.number_reflns_all 2160 _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.number_reflns_R_free 114 _refine_ls_shell.number_reflns_R_work 2046 _refine_ls_shell.percent_reflns_obs 85.4800 _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.R_factor_all ? _refine_ls_shell.R_factor_obs ? _refine_ls_shell.R_factor_R_free 0.2550 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.R_factor_R_work 0.2390 _refine_ls_shell.redundancy_reflns_all ? _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.wR_factor_all ? _refine_ls_shell.wR_factor_obs ? _refine_ls_shell.wR_factor_R_free ? _refine_ls_shell.wR_factor_R_work ? _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.pdbx_phase_error ? _refine_ls_shell.pdbx_fsc_work ? _refine_ls_shell.pdbx_fsc_free ? # _struct.entry_id 4ZCG _struct.title 'Crystal Structure of human GGT1 in complex with Glutamate (with all atoms of glutamate)' _struct.pdbx_descriptor ;GAMMA-GLUTAMYLTRANSPEPTIDASE 1 HEAVY CHAIN (E.C.2.3.2.2, 3.4.19.13, 3.4.19.14), GAMMA-GLUTAMYLTRANSPEPTIDASE 1 LIGHT CHAIN (E.C.2.3.2.2, 3.4.19.13, 3.4.19.14) ; _struct.pdbx_model_details Complex _struct.pdbx_formula_weight ? _struct.pdbx_formula_weight_method ? _struct.pdbx_model_type_details ? _struct.pdbx_CASP_flag ? # _struct_keywords.entry_id 4ZCG _struct_keywords.text 'NTN-HYDROLASE FAMILY, GLYCOPROTEIN, N- GLYCOSYLATION, CELL SURFACE, HYDROLASE' _struct_keywords.pdbx_keywords HYDROLASE # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 3 ? D N N 3 ? E N N 3 ? F N N 3 ? G N N 3 ? H N N 4 ? I N N 4 ? J N N 5 ? K N N 3 ? L N N 6 ? M N N 7 ? N N N 7 ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 AA1 ALA A 20 ? ASP A 33 ? ALA A 47 ASP A 60 1 ? 14 HELX_P HELX_P2 AA2 SER A 36 ? ASN A 52 ? SER A 63 ASN A 79 1 ? 17 HELX_P HELX_P3 AA3 SER A 94 ? LYS A 100 ? SER A 121 LYS A 127 1 ? 7 HELX_P HELX_P4 AA4 GLY A 101 ? VAL A 105 ? GLY A 128 VAL A 132 5 ? 5 HELX_P HELX_P5 AA5 GLY A 109 ? GLY A 122 ? GLY A 136 GLY A 149 1 ? 14 HELX_P HELX_P6 AA6 PRO A 125 ? GLY A 140 ? PRO A 152 GLY A 167 1 ? 16 HELX_P HELX_P7 AA7 GLY A 144 ? LYS A 154 ? GLY A 171 LYS A 181 1 ? 11 HELX_P HELX_P8 AA8 LYS A 154 ? GLN A 160 ? LYS A 181 GLN A 187 1 ? 7 HELX_P HELX_P9 AA9 GLN A 161 ? PHE A 168 ? GLN A 188 PHE A 195 1 ? 8 HELX_P HELX_P10 AB1 LEU A 183 ? GLY A 197 ? LEU A 210 GLY A 224 1 ? 15 HELX_P HELX_P11 AB2 ALA A 198 ? ASN A 203 ? ALA A 225 ASN A 230 1 ? 6 HELX_P HELX_P12 AB3 LEU A 206 ? ALA A 217 ? LEU A 233 ALA A 244 1 ? 12 HELX_P HELX_P13 AB4 THR A 222 ? TYR A 229 ? THR A 249 TYR A 256 1 ? 8 HELX_P HELX_P14 AB5 SER A 255 ? GLY A 268 ? SER A 282 GLY A 295 1 ? 14 HELX_P HELX_P15 AB6 SER A 272 ? GLU A 277 ? SER A 299 GLU A 304 5 ? 6 HELX_P HELX_P16 AB7 SER A 278 ? THR A 301 ? SER A 305 THR A 328 1 ? 24 HELX_P HELX_P17 AB8 VAL A 311 ? THR A 319 ? VAL A 338 THR A 346 1 ? 9 HELX_P HELX_P18 AB9 SER A 320 ? ALA A 329 ? SER A 347 ALA A 356 1 ? 10 HELX_P HELX_P19 AC1 PRO A 338 ? LYS A 343 ? PRO A 365 LYS A 370 5 ? 6 HELX_P HELX_P20 AC2 ASN B 39 ? PHE B 44 ? ASN B 419 PHE B 424 5 ? 6 HELX_P HELX_P21 AC3 SER B 58 ? PHE B 62 ? SER B 438 PHE B 442 5 ? 5 HELX_P HELX_P22 AC4 THR B 95 ? TRP B 110 ? THR B 475 TRP B 490 1 ? 16 HELX_P HELX_P23 AC5 ASP B 114 ? GLU B 121 ? ASP B 494 GLU B 501 1 ? 8 HELX_P HELX_P24 AC6 ASP B 140 ? ARG B 150 ? ASP B 520 ARG B 530 1 ? 11 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 23 SG ? ? ? 1_555 A CYS 47 SG ? ? A CYS 50 A CYS 74 1_555 ? ? ? ? ? ? ? 2.097 ? disulf2 disulf ? ? A CYS 165 SG ? ? ? 1_555 A CYS 169 SG ? ? A CYS 192 A CYS 196 1_555 ? ? ? ? ? ? ? 2.100 ? covale1 covale one ? A ASN 68 ND2 ? ? ? 1_555 C NAG . C1 ? ? A ASN 95 A NAG 601 1_555 ? ? ? ? ? ? ? 1.442 ? covale2 covale one ? A ASN 93 ND2 ? ? ? 1_555 D NAG . C1 ? ? A ASN 120 A NAG 602 1_555 ? ? ? ? ? ? ? 1.443 ? covale3 covale one ? A ASN 203 ND2 ? ? ? 1_555 G NAG . C1 ? ? A ASN 230 A NAG 605 1_555 ? ? ? ? ? ? ? 1.438 ? covale4 covale one ? A ASN 239 ND2 ? ? ? 1_555 F NAG . C1 ? ? A ASN 266 A NAG 604 1_555 ? ? ? ? ? ? ? 1.434 ? covale5 covale one ? A ASN 317 ND2 ? ? ? 1_555 E NAG . C1 ? ? A ASN 344 A NAG 603 1_555 ? ? ? ? ? ? ? 1.449 ? covale6 covale one ? B ASN 131 ND2 ? ? ? 1_555 K NAG . C1 ? ? B ASN 511 B NAG 1101 1_555 ? ? ? ? ? ? ? 1.429 ? metalc1 metalc ? ? B ALA 176 O ? ? ? 1_555 J NA . NA ? ? B ALA 556 A NA 608 1_555 ? ? ? ? ? ? ? 2.731 ? metalc2 metalc ? ? J NA . NA ? ? ? 1_555 M HOH . O ? ? A NA 608 A HOH 934 1_555 ? ? ? ? ? ? ? 2.702 ? metalc3 metalc ? ? J NA . NA ? ? ? 1_555 N HOH . O ? ? A NA 608 B HOH 1235 1_555 ? ? ? ? ? ? ? 3.009 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? metalc ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 ALA 252 A . ? ALA 279 A PRO 253 A ? PRO 280 A 1 11.34 2 LEU 129 B . ? LEU 509 B PRO 130 B ? PRO 510 B 1 0.22 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details AA1 ? 7 ? AA2 ? 7 ? AA3 ? 2 ? AA4 ? 2 ? AA5 ? 3 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense AA1 1 2 ? anti-parallel AA1 2 3 ? anti-parallel AA1 3 4 ? anti-parallel AA1 4 5 ? anti-parallel AA1 5 6 ? anti-parallel AA1 6 7 ? anti-parallel AA2 1 2 ? anti-parallel AA2 2 3 ? anti-parallel AA2 3 4 ? anti-parallel AA2 4 5 ? anti-parallel AA2 5 6 ? anti-parallel AA2 6 7 ? anti-parallel AA3 1 2 ? anti-parallel AA4 1 2 ? anti-parallel AA5 1 2 ? anti-parallel AA5 2 3 ? parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id AA1 1 VAL A 10 ? TYR A 11 ? VAL A 37 TYR A 38 AA1 2 GLY B 173 ? ALA B 177 ? GLY B 553 ALA B 557 AA1 3 VAL B 163 ? THR B 170 ? VAL B 543 THR B 550 AA1 4 VAL B 85 ? ALA B 92 ? VAL B 465 ALA B 472 AA1 5 THR B 76 ? GLY B 80 ? THR B 456 GLY B 460 AA1 6 ALA A 245 ? MET A 249 ? ALA A 272 MET A 276 AA1 7 LEU A 238 ? LEU A 242 ? LEU A 265 LEU A 269 AA2 1 GLU A 232 ? ILE A 234 ? GLU A 259 ILE A 261 AA2 2 LYS A 73 ? ALA A 79 ? LYS A 100 ALA A 106 AA2 3 GLY A 61 ? ASN A 68 ? GLY A 88 ASN A 95 AA2 4 ALA B 13 ? THR B 19 ? ALA B 393 THR B 399 AA2 5 ALA B 2 ? VAL B 7 ? ALA B 382 VAL B 387 AA2 6 ALA A 15 ? ALA A 17 ? ALA A 42 ALA A 44 AA2 7 ALA B 187 ? GLY B 188 ? ALA B 567 GLY B 568 AA3 1 PHE A 141 ? PRO A 142 ? PHE A 168 PRO A 169 AA3 2 ARG A 180 ? LEU A 181 ? ARG A 207 LEU A 208 AA4 1 CYS A 169 ? ARG A 170 ? CYS A 196 ARG A 197 AA4 2 LYS A 173 ? VAL A 174 ? LYS A 200 VAL A 201 AA5 1 LEU B 124 ? HIS B 125 ? LEU B 504 HIS B 505 AA5 2 THR B 133 ? VAL B 135 ? THR B 513 VAL B 515 AA5 3 THR B 154 ? ILE B 156 ? THR B 534 ILE B 536 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id AA1 1 2 N TYR A 11 ? N TYR A 38 O TRP B 174 ? O TRP B 554 AA1 2 3 O GLY B 173 ? O GLY B 553 N THR B 170 ? N THR B 550 AA1 3 4 O ILE B 167 ? O ILE B 547 N VAL B 88 ? N VAL B 468 AA1 4 5 O ARG B 86 ? O ARG B 466 N MET B 78 ? N MET B 458 AA1 5 6 O ILE B 77 ? O ILE B 457 N TYR A 248 ? N TYR A 275 AA1 6 7 O LEU A 247 ? O LEU A 274 N ILE A 240 ? N ILE A 267 AA2 1 2 O ILE A 234 ? O ILE A 261 N VAL A 76 ? N VAL A 103 AA2 2 3 O GLU A 75 ? O GLU A 102 N ILE A 66 ? N ILE A 93 AA2 3 4 N THR A 65 ? N THR A 92 O SER B 15 ? O SER B 395 AA2 4 5 O VAL B 14 ? O VAL B 394 N VAL B 6 ? N VAL B 386 AA2 5 6 O SER B 5 ? O SER B 385 N ALA A 17 ? N ALA A 44 AA2 6 7 N VAL A 16 ? N VAL A 43 O ALA B 187 ? O ALA B 567 AA3 1 2 N PHE A 141 ? N PHE A 168 O LEU A 181 ? O LEU A 208 AA4 1 2 N ARG A 170 ? N ARG A 197 O LYS A 173 ? O LYS A 200 AA5 1 2 N HIS B 125 ? N HIS B 505 O THR B 134 ? O THR B 514 AA5 2 3 N VAL B 135 ? N VAL B 515 O GLN B 155 ? O GLN B 535 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software A CL 606 ? 5 'binding site for residue CL A 606' AC2 Software A CL 607 ? 6 'binding site for residue CL A 607' AC3 Software A NA 608 ? 6 'binding site for residue NA A 608' AC4 Software B GLU 1102 ? 11 'binding site for residue GLU B 1102' AC5 Software A NAG 601 ? 7 'binding site for Mono-Saccharide NAG A 601 bound to ASN A 95' AC6 Software A NAG 602 ? 11 'binding site for Mono-Saccharide NAG A 602 bound to ASN A 120' AC7 Software A NAG 605 ? 5 'binding site for Mono-Saccharide NAG A 605 bound to ASN A 230' AC8 Software A NAG 604 ? 5 'binding site for Mono-Saccharide NAG A 604 bound to ASN A 266' AC9 Software A NAG 603 ? 8 'binding site for Mono-Saccharide NAG A 603 bound to ASN A 344' AD1 Software B NAG 1101 ? 9 'binding site for Mono-Saccharide NAG B 1101 bound to ASN B 511' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 5 LEU A 183 ? LEU A 210 . ? 1_555 ? 2 AC1 5 PRO A 184 ? PRO A 211 . ? 1_555 ? 3 AC1 5 GLN A 185 ? GLN A 212 . ? 1_555 ? 4 AC1 5 LEU A 186 ? LEU A 213 . ? 1_555 ? 5 AC1 5 ARG B 29 ? ARG B 409 . ? 1_555 ? 6 AC2 6 ASP A 19 ? ASP A 46 . ? 1_555 ? 7 AC2 6 ALA B 2 ? ALA B 382 . ? 1_555 ? 8 AC2 6 HIS B 3 ? HIS B 383 . ? 1_555 ? 9 AC2 6 VAL B 163 ? VAL B 543 . ? 1_555 ? 10 AC2 6 GLN B 165 ? GLN B 545 . ? 1_555 ? 11 AC2 6 HOH N . ? HOH B 1244 . ? 1_555 ? 12 AC3 6 HIS A 9 ? HIS A 36 . ? 1_555 ? 13 AC3 6 HOH M . ? HOH A 934 . ? 1_555 ? 14 AC3 6 LYS B 116 ? LYS B 496 . ? 1_555 ? 15 AC3 6 ALA B 176 ? ALA B 556 . ? 1_555 ? 16 AC3 6 ALA B 177 ? ALA B 557 . ? 1_555 ? 17 AC3 6 HOH N . ? HOH B 1235 . ? 1_555 ? 18 AC4 11 ARG A 80 ? ARG A 107 . ? 1_555 ? 19 AC4 11 THR B 1 ? THR B 381 . ? 1_555 ? 20 AC4 11 ASN B 21 ? ASN B 401 . ? 1_555 ? 21 AC4 11 GLU B 40 ? GLU B 420 . ? 1_555 ? 22 AC4 11 ASP B 43 ? ASP B 423 . ? 1_555 ? 23 AC4 11 SER B 71 ? SER B 451 . ? 1_555 ? 24 AC4 11 SER B 72 ? SER B 452 . ? 1_555 ? 25 AC4 11 GLY B 93 ? GLY B 473 . ? 1_555 ? 26 AC4 11 GLY B 94 ? GLY B 474 . ? 1_555 ? 27 AC4 11 HOH N . ? HOH B 1207 . ? 1_555 ? 28 AC4 11 HOH N . ? HOH B 1268 . ? 1_555 ? 29 AC5 7 ASN A 68 ? ASN A 95 . ? 1_555 ? 30 AC5 7 THR A 71 ? THR A 98 . ? 1_555 ? 31 AC5 7 HIS A 121 ? HIS A 148 . ? 1_555 ? 32 AC5 7 ARG A 123 ? ARG A 150 . ? 1_555 ? 33 AC5 7 HOH M . ? HOH A 721 . ? 1_555 ? 34 AC5 7 HOH M . ? HOH A 883 . ? 1_555 ? 35 AC5 7 SER B 12 ? SER B 392 . ? 1_555 ? 36 AC6 11 THR A 90 ? THR A 117 . ? 1_555 ? 37 AC6 11 MET A 91 ? MET A 118 . ? 1_555 ? 38 AC6 11 ASN A 93 ? ASN A 120 . ? 1_555 ? 39 AC6 11 GLN A 97 ? GLN A 124 . ? 1_555 ? 40 AC6 11 PRO A 279 ? PRO A 306 . ? 8_445 ? 41 AC6 11 HOH M . ? HOH A 722 . ? 1_555 ? 42 AC6 11 HOH M . ? HOH A 765 . ? 1_555 ? 43 AC6 11 HOH M . ? HOH A 892 . ? 1_555 ? 44 AC6 11 ASP B 140 ? ASP B 520 . ? 8_445 ? 45 AC6 11 ALA B 142 ? ALA B 522 . ? 8_445 ? 46 AC6 11 HOH N . ? HOH B 1230 . ? 8_445 ? 47 AC7 5 ASN A 203 ? ASN A 230 . ? 1_555 ? 48 AC7 5 THR A 207 ? THR A 234 . ? 1_555 ? 49 AC7 5 ASN A 227 ? ASN A 254 . ? 1_555 ? 50 AC7 5 HOH M . ? HOH A 889 . ? 1_555 ? 51 AC7 5 HOH M . ? HOH A 906 . ? 1_555 ? 52 AC8 5 ASN A 239 ? ASN A 266 . ? 1_555 ? 53 AC8 5 TYR A 248 ? TYR A 275 . ? 1_555 ? 54 AC8 5 ARG A 316 ? ARG A 343 . ? 4_555 ? 55 AC8 5 PHE A 322 ? PHE A 349 . ? 4_555 ? 56 AC8 5 HOH M . ? HOH A 754 . ? 1_555 ? 57 AC9 8 GLU A 313 ? GLU A 340 . ? 1_555 ? 58 AC9 8 ASN A 317 ? ASN A 344 . ? 1_555 ? 59 AC9 8 PHE A 323 ? PHE A 350 . ? 1_555 ? 60 AC9 8 GLN A 326 ? GLN A 353 . ? 1_555 ? 61 AC9 8 HOH M . ? HOH A 706 . ? 1_555 ? 62 AC9 8 HOH M . ? HOH A 710 . ? 1_555 ? 63 AC9 8 HOH M . ? HOH A 732 . ? 1_555 ? 64 AC9 8 HOH M . ? HOH A 876 . ? 1_555 ? 65 AD1 9 GLU A 191 ? GLU A 218 . ? 6_445 ? 66 AD1 9 THR A 336 ? THR A 363 . ? 1_555 ? 67 AD1 9 PRO A 338 ? PRO A 365 . ? 1_555 ? 68 AD1 9 ILE A 339 ? ILE A 366 . ? 1_555 ? 69 AD1 9 HOH M . ? HOH A 829 . ? 6_445 ? 70 AD1 9 ASN B 131 ? ASN B 511 . ? 1_555 ? 71 AD1 9 HIS B 151 ? HIS B 531 . ? 1_555 ? 72 AD1 9 HOH N . ? HOH B 1246 . ? 1_555 ? 73 AD1 9 HOH N . ? HOH B 1283 . ? 1_555 ? # _atom_sites.entry_id 4ZCG _atom_sites.fract_transf_matrix[1][1] 0.009502 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] -0.000000 _atom_sites.fract_transf_matrix[2][2] 0.007985 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] -0.000000 _atom_sites.fract_transf_matrix[3][3] 0.009610 _atom_sites.fract_transf_vector[1] 0.000000 _atom_sites.fract_transf_vector[2] 0.000000 _atom_sites.fract_transf_vector[3] 0.000000 # loop_ _atom_type.symbol C CL N NA O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . ASP A 1 7 ? -5.069 -20.236 -30.974 1.00 98.86 ? 34 ASP A N 1 ATOM 2 C CA . ASP A 1 7 ? -3.656 -20.726 -30.897 1.00 101.68 ? 34 ASP A CA 1 ATOM 3 C C . ASP A 1 7 ? -2.950 -20.167 -29.659 1.00 93.49 ? 34 ASP A C 1 ATOM 4 O O . ASP A 1 7 ? -2.322 -20.908 -28.898 1.00 94.69 ? 34 ASP A O 1 ATOM 5 C CB . ASP A 1 7 ? -2.887 -20.331 -32.160 1.00 108.09 ? 34 ASP A CB 1 ATOM 6 C CG . ASP A 1 7 ? -3.527 -20.869 -33.432 1.00 114.76 ? 34 ASP A CG 1 ATOM 7 O OD1 . ASP A 1 7 ? -3.769 -22.094 -33.516 1.00 118.04 ? 34 ASP A OD1 1 ATOM 8 O OD2 . ASP A 1 7 ? -3.783 -20.067 -34.356 1.00 121.42 ? 34 ASP A OD2 1 ATOM 9 N N . ASN A 1 8 ? -3.053 -18.851 -29.491 1.00 82.52 ? 35 ASN A N 1 ATOM 10 C CA . ASN A 1 8 ? -2.592 -18.140 -28.295 1.00 77.85 ? 35 ASN A CA 1 ATOM 11 C C . ASN A 1 8 ? -3.773 -17.739 -27.360 1.00 68.74 ? 35 ASN A C 1 ATOM 12 O O . ASN A 1 8 ? -3.636 -17.607 -26.126 1.00 62.72 ? 35 ASN A O 1 ATOM 13 C CB . ASN A 1 8 ? -1.800 -16.908 -28.746 1.00 81.32 ? 35 ASN A CB 1 ATOM 14 C CG . ASN A 1 8 ? -0.457 -17.255 -29.358 1.00 88.08 ? 35 ASN A CG 1 ATOM 15 O OD1 . ASN A 1 8 ? 0.097 -18.327 -29.092 1.00 94.10 ? 35 ASN A OD1 1 ATOM 16 N ND2 . ASN A 1 8 ? 0.068 -16.359 -30.192 1.00 98.89 ? 35 ASN A ND2 1 ATOM 17 N N . HIS A 1 9 ? -4.934 -17.536 -27.967 1.00 54.86 ? 36 HIS A N 1 ATOM 18 C CA . HIS A 1 9 ? -6.155 -17.234 -27.237 1.00 49.51 ? 36 HIS A CA 1 ATOM 19 C C . HIS A 1 9 ? -6.181 -15.814 -26.664 1.00 47.29 ? 36 HIS A C 1 ATOM 20 O O . HIS A 1 9 ? -6.919 -15.559 -25.708 1.00 45.26 ? 36 HIS A O 1 ATOM 21 C CB . HIS A 1 9 ? -6.447 -18.278 -26.144 1.00 44.62 ? 36 HIS A CB 1 ATOM 22 C CG . HIS A 1 9 ? -6.317 -19.697 -26.604 1.00 42.22 ? 36 HIS A CG 1 ATOM 23 N ND1 . HIS A 1 9 ? -7.036 -20.203 -27.664 1.00 43.49 ? 36 HIS A ND1 1 ATOM 24 C CD2 . HIS A 1 9 ? -5.556 -20.720 -26.150 1.00 40.82 ? 36 HIS A CD2 1 ATOM 25 C CE1 . HIS A 1 9 ? -6.717 -21.471 -27.848 1.00 40.16 ? 36 HIS A CE1 1 ATOM 26 N NE2 . HIS A 1 9 ? -5.829 -21.811 -26.935 1.00 41.74 ? 36 HIS A NE2 1 ATOM 27 N N . VAL A 1 10 ? -5.380 -14.909 -27.240 1.00 41.78 ? 37 VAL A N 1 ATOM 28 C CA . VAL A 1 10 ? -5.594 -13.466 -27.092 1.00 39.89 ? 37 VAL A CA 1 ATOM 29 C C . VAL A 1 10 ? -6.210 -12.988 -28.396 1.00 39.31 ? 37 VAL A C 1 ATOM 30 O O . VAL A 1 10 ? -5.707 -13.282 -29.469 1.00 42.04 ? 37 VAL A O 1 ATOM 31 C CB . VAL A 1 10 ? -4.295 -12.693 -26.809 1.00 40.33 ? 37 VAL A CB 1 ATOM 32 C CG1 . VAL A 1 10 ? -4.566 -11.198 -26.707 1.00 40.02 ? 37 VAL A CG1 1 ATOM 33 C CG2 . VAL A 1 10 ? -3.665 -13.202 -25.520 1.00 39.90 ? 37 VAL A CG2 1 ATOM 34 N N . TYR A 1 11 ? -7.335 -12.297 -28.310 1.00 36.85 ? 38 TYR A N 1 ATOM 35 C CA . TYR A 1 11 ? -8.080 -11.941 -29.490 1.00 34.59 ? 38 TYR A CA 1 ATOM 36 C C . TYR A 1 11 ? -8.329 -10.458 -29.492 1.00 36.47 ? 38 TYR A C 1 ATOM 37 O O . TYR A 1 11 ? -8.637 -9.887 -28.453 1.00 38.58 ? 38 TYR A O 1 ATOM 38 C CB . TYR A 1 11 ? -9.398 -12.691 -29.511 1.00 34.63 ? 38 TYR A CB 1 ATOM 39 C CG . TYR A 1 11 ? -9.251 -14.192 -29.446 1.00 36.16 ? 38 TYR A CG 1 ATOM 40 C CD1 . TYR A 1 11 ? -8.827 -14.930 -30.566 1.00 37.67 ? 38 TYR A CD1 1 ATOM 41 C CD2 . TYR A 1 11 ? -9.566 -14.886 -28.281 1.00 35.68 ? 38 TYR A CD2 1 ATOM 42 C CE1 . TYR A 1 11 ? -8.703 -16.309 -30.506 1.00 39.18 ? 38 TYR A CE1 1 ATOM 43 C CE2 . TYR A 1 11 ? -9.438 -16.253 -28.210 1.00 36.98 ? 38 TYR A CE2 1 ATOM 44 C CZ . TYR A 1 11 ? -9.020 -16.961 -29.317 1.00 37.85 ? 38 TYR A CZ 1 ATOM 45 O OH . TYR A 1 11 ? -8.913 -18.318 -29.207 1.00 37.21 ? 38 TYR A OH 1 ATOM 46 N N . THR A 1 12 ? -8.216 -9.840 -30.664 1.00 37.58 ? 39 THR A N 1 ATOM 47 C CA . THR A 1 12 ? -8.289 -8.388 -30.789 1.00 39.22 ? 39 THR A CA 1 ATOM 48 C C . THR A 1 12 ? -9.687 -7.883 -30.619 1.00 37.92 ? 39 THR A C 1 ATOM 49 O O . THR A 1 12 ? -9.891 -6.760 -30.133 1.00 37.28 ? 39 THR A O 1 ATOM 50 C CB . THR A 1 12 ? -7.801 -7.917 -32.188 1.00 44.34 ? 39 THR A CB 1 ATOM 51 O OG1 . THR A 1 12 ? -6.477 -8.395 -32.409 1.00 49.79 ? 39 THR A OG1 1 ATOM 52 C CG2 . THR A 1 12 ? -7.745 -6.416 -32.267 1.00 48.77 ? 39 THR A CG2 1 ATOM 53 N N . ARG A 1 13 ? -10.660 -8.684 -31.042 1.00 36.80 ? 40 ARG A N 1 ATOM 54 C CA . ARG A 1 13 ? -12.022 -8.183 -31.158 1.00 38.87 ? 40 ARG A CA 1 ATOM 55 C C . ARG A 1 13 ? -13.045 -8.882 -30.251 1.00 36.09 ? 40 ARG A C 1 ATOM 56 O O . ARG A 1 13 ? -13.926 -8.234 -29.716 1.00 36.69 ? 40 ARG A O 1 ATOM 57 C CB . ARG A 1 13 ? -12.459 -8.260 -32.631 1.00 44.13 ? 40 ARG A CB 1 ATOM 58 C CG . ARG A 1 13 ? -11.579 -7.419 -33.577 1.00 49.91 ? 40 ARG A CG 1 ATOM 59 C CD . ARG A 1 13 ? -11.689 -7.830 -35.043 1.00 52.99 ? 40 ARG A CD 1 ATOM 60 N NE . ARG A 1 13 ? -12.959 -7.411 -35.634 1.00 59.63 ? 40 ARG A NE 1 ATOM 61 C CZ . ARG A 1 13 ? -13.455 -7.855 -36.795 1.00 65.64 ? 40 ARG A CZ 1 ATOM 62 N NH1 . ARG A 1 13 ? -12.797 -8.750 -37.541 1.00 68.96 ? 40 ARG A NH1 1 ATOM 63 N NH2 . ARG A 1 13 ? -14.631 -7.401 -37.217 1.00 65.23 ? 40 ARG A NH2 1 ATOM 64 N N . ALA A 1 14 ? -12.961 -10.199 -30.100 1.00 35.96 ? 41 ALA A N 1 ATOM 65 C CA . ALA A 1 14 ? -14.014 -10.930 -29.383 1.00 33.43 ? 41 ALA A CA 1 ATOM 66 C C . ALA A 1 14 ? -13.580 -12.308 -28.981 1.00 31.89 ? 41 ALA A C 1 ATOM 67 O O . ALA A 1 14 ? -12.717 -12.901 -29.622 1.00 32.23 ? 41 ALA A O 1 ATOM 68 C CB . ALA A 1 14 ? -15.256 -11.019 -30.235 1.00 33.84 ? 41 ALA A CB 1 ATOM 69 N N . ALA A 1 15 ? -14.218 -12.842 -27.939 1.00 30.41 ? 42 ALA A N 1 ATOM 70 C CA . ALA A 1 15 ? -13.810 -14.131 -27.409 1.00 27.58 ? 42 ALA A CA 1 ATOM 71 C C . ALA A 1 15 ? -14.927 -14.931 -26.724 1.00 27.49 ? 42 ALA A C 1 ATOM 72 O O . ALA A 1 15 ? -15.860 -14.377 -26.146 1.00 27.24 ? 42 ALA A O 1 ATOM 73 C CB . ALA A 1 15 ? -12.655 -13.935 -26.465 1.00 27.64 ? 42 ALA A CB 1 ATOM 74 N N . VAL A 1 16 ? -14.806 -16.252 -26.829 1.00 27.11 ? 43 VAL A N 1 ATOM 75 C CA . VAL A 1 16 ? -15.716 -17.204 -26.215 1.00 25.25 ? 43 VAL A CA 1 ATOM 76 C C . VAL A 1 16 ? -14.848 -18.225 -25.519 1.00 25.30 ? 43 VAL A C 1 ATOM 77 O O . VAL A 1 16 ? -13.975 -18.846 -26.144 1.00 26.93 ? 43 VAL A O 1 ATOM 78 C CB . VAL A 1 16 ? -16.649 -17.875 -27.252 1.00 25.49 ? 43 VAL A CB 1 ATOM 79 C CG1 . VAL A 1 16 ? -17.577 -18.891 -26.581 1.00 27.34 ? 43 VAL A CG1 1 ATOM 80 C CG2 . VAL A 1 16 ? -17.494 -16.831 -27.963 1.00 23.91 ? 43 VAL A CG2 1 ATOM 81 N N . ALA A 1 17 ? -15.069 -18.368 -24.212 1.00 24.50 ? 44 ALA A N 1 ATOM 82 C CA . ALA A 1 17 ? -14.453 -19.388 -23.399 1.00 22.54 ? 44 ALA A CA 1 ATOM 83 C C . ALA A 1 17 ? -15.505 -20.350 -22.831 1.00 22.86 ? 44 ALA A C 1 ATOM 84 O O . ALA A 1 17 ? -16.155 -20.050 -21.827 1.00 21.11 ? 44 ALA A O 1 ATOM 85 C CB . ALA A 1 17 ? -13.680 -18.742 -22.263 1.00 22.65 ? 44 ALA A CB 1 ATOM 86 N N . ALA A 1 18 ? -15.631 -21.494 -23.498 1.00 23.39 ? 45 ALA A N 1 ATOM 87 C CA . ALA A 1 18 ? -16.429 -22.622 -23.094 1.00 23.87 ? 45 ALA A CA 1 ATOM 88 C C . ALA A 1 18 ? -15.538 -23.806 -22.734 1.00 25.65 ? 45 ALA A C 1 ATOM 89 O O . ALA A 1 18 ? -14.333 -23.804 -22.987 1.00 27.58 ? 45 ALA A O 1 ATOM 90 C CB . ALA A 1 18 ? -17.350 -23.024 -24.244 1.00 24.63 ? 45 ALA A CB 1 ATOM 91 N N . ASP A 1 19 ? -16.173 -24.840 -22.194 1.00 26.28 ? 46 ASP A N 1 ATOM 92 C CA . ASP A 1 19 ? -15.495 -26.019 -21.713 1.00 28.24 ? 46 ASP A CA 1 ATOM 93 C C . ASP A 1 19 ? -15.386 -27.150 -22.759 1.00 30.55 ? 46 ASP A C 1 ATOM 94 O O . ASP A 1 19 ? -14.970 -28.271 -22.423 1.00 31.82 ? 46 ASP A O 1 ATOM 95 C CB . ASP A 1 19 ? -16.162 -26.518 -20.431 1.00 30.21 ? 46 ASP A CB 1 ATOM 96 C CG . ASP A 1 19 ? -17.568 -27.055 -20.639 1.00 31.75 ? 46 ASP A CG 1 ATOM 97 O OD1 . ASP A 1 19 ? -18.005 -27.296 -21.785 1.00 35.68 ? 46 ASP A OD1 1 ATOM 98 O OD2 . ASP A 1 19 ? -18.239 -27.276 -19.622 1.00 31.19 ? 46 ASP A OD2 1 ATOM 99 N N . ALA A 1 20 ? -15.757 -26.840 -23.999 1.00 28.36 ? 47 ALA A N 1 ATOM 100 C CA . ALA A 1 20 ? -15.473 -27.689 -25.155 1.00 32.19 ? 47 ALA A CA 1 ATOM 101 C C . ALA A 1 20 ? -15.089 -26.811 -26.338 1.00 31.29 ? 47 ALA A C 1 ATOM 102 O O . ALA A 1 20 ? -15.766 -25.820 -26.629 1.00 29.97 ? 47 ALA A O 1 ATOM 103 C CB . ALA A 1 20 ? -16.685 -28.527 -25.517 1.00 31.96 ? 47 ALA A CB 1 ATOM 104 N N . LYS A 1 21 ? -14.024 -27.194 -27.028 1.00 31.53 ? 48 LYS A N 1 ATOM 105 C CA . LYS A 1 21 ? -13.483 -26.392 -28.138 1.00 32.43 ? 48 LYS A CA 1 ATOM 106 C C . LYS A 1 21 ? -14.522 -26.050 -29.191 1.00 30.86 ? 48 LYS A C 1 ATOM 107 O O . LYS A 1 21 ? -14.654 -24.911 -29.579 1.00 28.90 ? 48 LYS A O 1 ATOM 108 C CB . LYS A 1 21 ? -12.340 -27.145 -28.803 1.00 36.96 ? 48 LYS A CB 1 ATOM 109 C CG . LYS A 1 21 ? -11.620 -26.341 -29.870 1.00 45.24 ? 48 LYS A CG 1 ATOM 110 C CD . LYS A 1 21 ? -10.628 -27.201 -30.647 1.00 52.25 ? 48 LYS A CD 1 ATOM 111 C CE . LYS A 1 21 ? -9.680 -26.328 -31.468 1.00 59.03 ? 48 LYS A CE 1 ATOM 112 N NZ . LYS A 1 21 ? -8.833 -27.130 -32.410 1.00 63.55 ? 48 LYS A NZ 1 ATOM 113 N N . GLN A 1 22 ? -15.279 -27.049 -29.628 1.00 31.82 ? 49 GLN A N 1 ATOM 114 C CA . GLN A 1 22 ? -16.228 -26.887 -30.713 1.00 32.67 ? 49 GLN A CA 1 ATOM 115 C C . GLN A 1 22 ? -17.342 -25.929 -30.298 1.00 31.39 ? 49 GLN A C 1 ATOM 116 O O . GLN A 1 22 ? -17.856 -25.168 -31.108 1.00 32.17 ? 49 GLN A O 1 ATOM 117 C CB . GLN A 1 22 ? -16.784 -28.277 -31.111 1.00 37.40 ? 49 GLN A CB 1 ATOM 118 C CG . GLN A 1 22 ? -17.596 -28.330 -32.406 1.00 43.79 ? 49 GLN A CG 1 ATOM 119 C CD . GLN A 1 22 ? -16.911 -27.610 -33.570 1.00 50.75 ? 49 GLN A CD 1 ATOM 120 O OE1 . GLN A 1 22 ? -17.511 -26.738 -34.212 1.00 51.54 ? 49 GLN A OE1 1 ATOM 121 N NE2 . GLN A 1 22 ? -15.623 -27.939 -33.815 1.00 50.39 ? 49 GLN A NE2 1 ATOM 122 N N . CYS A 1 23 ? -17.711 -25.943 -29.024 1.00 29.13 ? 50 CYS A N 1 ATOM 123 C CA . CYS A 1 23 ? -18.750 -25.029 -28.552 1.00 28.32 ? 50 CYS A CA 1 ATOM 124 C C . CYS A 1 23 ? -18.236 -23.606 -28.468 1.00 25.82 ? 50 CYS A C 1 ATOM 125 O O . CYS A 1 23 ? -18.961 -22.690 -28.833 1.00 26.41 ? 50 CYS A O 1 ATOM 126 C CB . CYS A 1 23 ? -19.334 -25.467 -27.221 1.00 27.68 ? 50 CYS A CB 1 ATOM 127 S SG . CYS A 1 23 ? -19.963 -27.156 -27.236 1.00 31.32 ? 50 CYS A SG 1 ATOM 128 N N . SER A 1 24 ? -17.002 -23.399 -28.025 1.00 24.86 ? 51 SER A N 1 ATOM 129 C CA . SER A 1 24 ? -16.437 -22.053 -28.089 1.00 26.82 ? 51 SER A CA 1 ATOM 130 C C . SER A 1 24 ? -16.461 -21.542 -29.528 1.00 27.79 ? 51 SER A C 1 ATOM 131 O O . SER A 1 24 ? -16.837 -20.400 -29.779 1.00 27.22 ? 51 SER A O 1 ATOM 132 C CB . SER A 1 24 ? -14.989 -22.009 -27.561 1.00 27.34 ? 51 SER A CB 1 ATOM 133 O OG . SER A 1 24 ? -14.860 -22.621 -26.301 1.00 26.88 ? 51 SER A OG 1 ATOM 134 N N . LYS A 1 25 ? -16.064 -22.404 -30.468 1.00 30.03 ? 52 LYS A N 1 ATOM 135 C CA . LYS A 1 25 ? -16.069 -22.066 -31.902 1.00 32.78 ? 52 LYS A CA 1 ATOM 136 C C . LYS A 1 25 ? -17.436 -21.697 -32.430 1.00 29.15 ? 52 LYS A C 1 ATOM 137 O O . LYS A 1 25 ? -17.584 -20.741 -33.208 1.00 28.54 ? 52 LYS A O 1 ATOM 138 C CB . LYS A 1 25 ? -15.490 -23.213 -32.744 1.00 37.98 ? 52 LYS A CB 1 ATOM 139 C CG . LYS A 1 25 ? -14.001 -23.419 -32.519 1.00 44.02 ? 52 LYS A CG 1 ATOM 140 C CD . LYS A 1 25 ? -13.388 -24.441 -33.472 1.00 51.77 ? 52 LYS A CD 1 ATOM 141 C CE . LYS A 1 25 ? -11.893 -24.160 -33.609 1.00 61.34 ? 52 LYS A CE 1 ATOM 142 N NZ . LYS A 1 25 ? -11.139 -25.195 -34.384 1.00 69.01 ? 52 LYS A NZ 1 ATOM 143 N N . ILE A 1 26 ? -18.438 -22.445 -32.003 1.00 28.76 ? 53 ILE A N 1 ATOM 144 C CA . ILE A 1 26 ? -19.816 -22.169 -32.409 1.00 30.14 ? 53 ILE A CA 1 ATOM 145 C C . ILE A 1 26 ? -20.271 -20.809 -31.888 1.00 30.21 ? 53 ILE A C 1 ATOM 146 O O . ILE A 1 26 ? -20.891 -20.037 -32.609 1.00 29.48 ? 53 ILE A O 1 ATOM 147 C CB . ILE A 1 26 ? -20.735 -23.302 -31.948 1.00 31.53 ? 53 ILE A CB 1 ATOM 148 C CG1 . ILE A 1 26 ? -20.620 -24.453 -32.961 1.00 30.46 ? 53 ILE A CG1 1 ATOM 149 C CG2 . ILE A 1 26 ? -22.172 -22.827 -31.766 1.00 31.91 ? 53 ILE A CG2 1 ATOM 150 C CD1 . ILE A 1 26 ? -21.297 -25.720 -32.493 1.00 29.37 ? 53 ILE A CD1 1 ATOM 151 N N . GLY A 1 27 ? -19.899 -20.497 -30.651 1.00 30.90 ? 54 GLY A N 1 ATOM 152 C CA . GLY A 1 27 ? -20.157 -19.179 -30.095 1.00 30.84 ? 54 GLY A CA 1 ATOM 153 C C . GLY A 1 27 ? -19.459 -18.108 -30.909 1.00 30.28 ? 54 GLY A C 1 ATOM 154 O O . GLY A 1 27 ? -20.052 -17.095 -31.280 1.00 27.53 ? 54 GLY A O 1 ATOM 155 N N . ARG A 1 28 ? -18.195 -18.353 -31.196 1.00 29.09 ? 55 ARG A N 1 ATOM 156 C CA . ARG A 1 28 ? -17.398 -17.423 -31.973 1.00 31.26 ? 55 ARG A CA 1 ATOM 157 C C . ARG A 1 28 ? -17.998 -17.175 -33.372 1.00 32.36 ? 55 ARG A C 1 ATOM 158 O O . ARG A 1 28 ? -18.126 -16.025 -33.790 1.00 31.12 ? 55 ARG A O 1 ATOM 159 C CB . ARG A 1 28 ? -15.972 -17.957 -32.062 1.00 33.70 ? 55 ARG A CB 1 ATOM 160 C CG . ARG A 1 28 ? -14.968 -17.034 -32.735 1.00 34.61 ? 55 ARG A CG 1 ATOM 161 C CD . ARG A 1 28 ? -14.933 -17.176 -34.250 1.00 35.82 ? 55 ARG A CD 1 ATOM 162 N NE . ARG A 1 28 ? -14.711 -18.536 -34.724 1.00 37.29 ? 55 ARG A NE 1 ATOM 163 C CZ . ARG A 1 28 ? -13.565 -19.198 -34.660 1.00 41.77 ? 55 ARG A CZ 1 ATOM 164 N NH1 . ARG A 1 28 ? -12.494 -18.642 -34.102 1.00 46.65 ? 55 ARG A NH1 1 ATOM 165 N NH2 . ARG A 1 28 ? -13.491 -20.444 -35.132 1.00 44.15 ? 55 ARG A NH2 1 ATOM 166 N N . ASP A 1 29 ? -18.396 -18.230 -34.082 1.00 31.94 ? 56 ASP A N 1 ATOM 167 C CA . ASP A 1 29 ? -19.053 -18.032 -35.396 1.00 34.83 ? 56 ASP A CA 1 ATOM 168 C C . ASP A 1 29 ? -20.326 -17.197 -35.334 1.00 35.98 ? 56 ASP A C 1 ATOM 169 O O . ASP A 1 29 ? -20.637 -16.451 -36.266 1.00 37.40 ? 56 ASP A O 1 ATOM 170 C CB . ASP A 1 29 ? -19.389 -19.364 -36.065 1.00 35.94 ? 56 ASP A CB 1 ATOM 171 C CG . ASP A 1 29 ? -18.169 -20.194 -36.323 1.00 37.63 ? 56 ASP A CG 1 ATOM 172 O OD1 . ASP A 1 29 ? -17.045 -19.634 -36.251 1.00 35.70 ? 56 ASP A OD1 1 ATOM 173 O OD2 . ASP A 1 29 ? -18.337 -21.412 -36.561 1.00 43.67 ? 56 ASP A OD2 1 ATOM 174 N N . ALA A 1 30 ? -21.075 -17.336 -34.248 1.00 34.43 ? 57 ALA A N 1 ATOM 175 C CA . ALA A 1 30 ? -22.278 -16.548 -34.083 1.00 34.59 ? 57 ALA A CA 1 ATOM 176 C C . ALA A 1 30 ? -21.913 -15.077 -33.987 1.00 32.92 ? 57 ALA A C 1 ATOM 177 O O . ALA A 1 30 ? -22.571 -14.230 -34.579 1.00 29.47 ? 57 ALA A O 1 ATOM 178 C CB . ALA A 1 30 ? -23.045 -16.994 -32.839 1.00 34.99 ? 57 ALA A CB 1 ATOM 179 N N . LEU A 1 31 ? -20.869 -14.780 -33.218 1.00 34.20 ? 58 LEU A N 1 ATOM 180 C CA . LEU A 1 31 ? -20.380 -13.417 -33.124 1.00 36.34 ? 58 LEU A CA 1 ATOM 181 C C . LEU A 1 31 ? -19.963 -12.908 -34.500 1.00 37.38 ? 58 LEU A C 1 ATOM 182 O O . LEU A 1 31 ? -20.378 -11.826 -34.898 1.00 36.46 ? 58 LEU A O 1 ATOM 183 C CB . LEU A 1 31 ? -19.222 -13.316 -32.139 1.00 34.85 ? 58 LEU A CB 1 ATOM 184 C CG . LEU A 1 31 ? -19.563 -13.551 -30.670 1.00 36.01 ? 58 LEU A CG 1 ATOM 185 C CD1 . LEU A 1 31 ? -18.309 -13.505 -29.807 1.00 36.05 ? 58 LEU A CD1 1 ATOM 186 C CD2 . LEU A 1 31 ? -20.577 -12.535 -30.189 1.00 36.51 ? 58 LEU A CD2 1 ATOM 187 N N . ARG A 1 32 ? -19.179 -13.713 -35.217 1.00 42.38 ? 59 ARG A N 1 ATOM 188 C CA A ARG A 1 32 ? -18.727 -13.369 -36.569 0.50 43.59 ? 59 ARG A CA 1 ATOM 189 C CA B ARG A 1 32 ? -18.727 -13.369 -36.569 0.50 43.59 ? 59 ARG A CA 1 ATOM 190 C C . ARG A 1 32 ? -19.880 -13.059 -37.508 1.00 41.89 ? 59 ARG A C 1 ATOM 191 O O . ARG A 1 32 ? -19.783 -12.138 -38.303 1.00 39.74 ? 59 ARG A O 1 ATOM 192 C CB A ARG A 1 32 ? -17.874 -14.484 -37.178 0.50 47.68 ? 59 ARG A CB 1 ATOM 193 C CB B ARG A 1 32 ? -17.874 -14.484 -37.178 0.50 47.68 ? 59 ARG A CB 1 ATOM 194 C CG . ARG A 1 32 ? -16.382 -14.226 -37.091 1.00 52.90 ? 59 ARG A CG 1 ATOM 195 C CD . ARG A 1 32 ? -15.597 -15.051 -38.104 1.00 59.54 ? 59 ARG A CD 1 ATOM 196 N NE . ARG A 1 32 ? -14.153 -14.815 -37.985 1.00 71.07 ? 59 ARG A NE 1 ATOM 197 C CZ . ARG A 1 32 ? -13.531 -13.659 -38.269 1.00 74.81 ? 59 ARG A CZ 1 ATOM 198 N NH1 . ARG A 1 32 ? -14.206 -12.584 -38.690 1.00 75.96 ? 59 ARG A NH1 1 ATOM 199 N NH2 . ARG A 1 32 ? -12.210 -13.568 -38.121 1.00 73.33 ? 59 ARG A NH2 1 ATOM 200 N N . ASP A 1 33 ? -20.964 -13.831 -37.405 1.00 37.44 ? 60 ASP A N 1 ATOM 201 C CA . ASP A 1 33 ? -22.145 -13.633 -38.256 1.00 37.09 ? 60 ASP A CA 1 ATOM 202 C C . ASP A 1 33 ? -23.045 -12.503 -37.771 1.00 36.53 ? 60 ASP A C 1 ATOM 203 O O . ASP A 1 33 ? -24.152 -12.350 -38.286 1.00 36.17 ? 60 ASP A O 1 ATOM 204 C CB . ASP A 1 33 ? -22.993 -14.915 -38.342 1.00 39.59 ? 60 ASP A CB 1 ATOM 205 C CG . ASP A 1 33 ? -22.299 -16.054 -39.070 1.00 41.55 ? 60 ASP A CG 1 ATOM 206 O OD1 . ASP A 1 33 ? -21.245 -15.843 -39.710 1.00 43.70 ? 60 ASP A OD1 1 ATOM 207 O OD2 . ASP A 1 33 ? -22.815 -17.186 -38.988 1.00 43.30 ? 60 ASP A OD2 1 ATOM 208 N N . GLY A 1 34 ? -22.613 -11.725 -36.778 1.00 35.30 ? 61 GLY A N 1 ATOM 209 C CA . GLY A 1 34 ? -23.386 -10.548 -36.328 1.00 36.15 ? 61 GLY A CA 1 ATOM 210 C C . GLY A 1 34 ? -24.198 -10.698 -35.030 1.00 36.38 ? 61 GLY A C 1 ATOM 211 O O . GLY A 1 34 ? -24.904 -9.768 -34.630 1.00 37.96 ? 61 GLY A O 1 ATOM 212 N N . GLY A 1 35 ? -24.108 -11.849 -34.367 1.00 33.59 ? 62 GLY A N 1 ATOM 213 C CA . GLY A 1 35 ? -24.812 -12.041 -33.111 1.00 32.35 ? 62 GLY A CA 1 ATOM 214 C C . GLY A 1 35 ? -24.279 -11.187 -31.962 1.00 30.70 ? 62 GLY A C 1 ATOM 215 O O . GLY A 1 35 ? -23.103 -10.822 -31.920 1.00 30.71 ? 62 GLY A O 1 ATOM 216 N N . SER A 1 36 ? -25.157 -10.889 -31.014 1.00 29.02 ? 63 SER A N 1 ATOM 217 C CA . SER A 1 36 ? -24.740 -10.308 -29.740 1.00 31.00 ? 63 SER A CA 1 ATOM 218 C C . SER A 1 36 ? -24.013 -11.356 -28.892 1.00 29.74 ? 63 SER A C 1 ATOM 219 O O . SER A 1 36 ? -23.908 -12.553 -29.248 1.00 26.39 ? 63 SER A O 1 ATOM 220 C CB . SER A 1 36 ? -25.944 -9.780 -28.961 1.00 31.82 ? 63 SER A CB 1 ATOM 221 O OG . SER A 1 36 ? -26.806 -10.834 -28.585 1.00 32.93 ? 63 SER A OG 1 ATOM 222 N N . ALA A 1 37 ? -23.485 -10.881 -27.779 1.00 29.25 ? 64 ALA A N 1 ATOM 223 C CA . ALA A 1 37 ? -22.854 -11.766 -26.822 1.00 29.44 ? 64 ALA A CA 1 ATOM 224 C C . ALA A 1 37 ? -23.881 -12.808 -26.311 1.00 28.39 ? 64 ALA A C 1 ATOM 225 O O . ALA A 1 37 ? -23.522 -13.945 -26.042 1.00 29.48 ? 64 ALA A O 1 ATOM 226 C CB . ALA A 1 37 ? -22.262 -10.962 -25.680 1.00 28.94 ? 64 ALA A CB 1 ATOM 227 N N . VAL A 1 38 ? -25.146 -12.415 -26.203 1.00 26.80 ? 65 VAL A N 1 ATOM 228 C CA . VAL A 1 38 ? -26.187 -13.331 -25.782 1.00 26.84 ? 65 VAL A CA 1 ATOM 229 C C . VAL A 1 38 ? -26.431 -14.428 -26.834 1.00 27.50 ? 65 VAL A C 1 ATOM 230 O O . VAL A 1 38 ? -26.486 -15.598 -26.476 1.00 27.26 ? 65 VAL A O 1 ATOM 231 C CB . VAL A 1 38 ? -27.478 -12.583 -25.438 1.00 25.75 ? 65 VAL A CB 1 ATOM 232 C CG1 . VAL A 1 38 ? -28.701 -13.499 -25.472 1.00 26.45 ? 65 VAL A CG1 1 ATOM 233 C CG2 . VAL A 1 38 ? -27.344 -11.964 -24.066 1.00 27.14 ? 65 VAL A CG2 1 ATOM 234 N N . ASP A 1 39 ? -26.564 -14.058 -28.106 1.00 28.22 ? 66 ASP A N 1 ATOM 235 C CA . ASP A 1 39 ? -26.688 -15.035 -29.194 1.00 28.74 ? 66 ASP A CA 1 ATOM 236 C C . ASP A 1 39 ? -25.569 -16.072 -29.118 1.00 27.80 ? 66 ASP A C 1 ATOM 237 O O . ASP A 1 39 ? -25.806 -17.259 -29.204 1.00 28.60 ? 66 ASP A O 1 ATOM 238 C CB . ASP A 1 39 ? -26.544 -14.362 -30.553 1.00 32.07 ? 66 ASP A CB 1 ATOM 239 C CG . ASP A 1 39 ? -27.697 -13.439 -30.903 1.00 32.49 ? 66 ASP A CG 1 ATOM 240 O OD1 . ASP A 1 39 ? -28.856 -13.779 -30.639 1.00 37.01 ? 66 ASP A OD1 1 ATOM 241 O OD2 . ASP A 1 39 ? -27.439 -12.360 -31.489 1.00 37.01 ? 66 ASP A OD2 1 ATOM 242 N N . ALA A 1 40 ? -24.339 -15.596 -28.970 1.00 27.65 ? 67 ALA A N 1 ATOM 243 C CA . ALA A 1 40 ? -23.187 -16.471 -28.893 1.00 27.30 ? 67 ALA A CA 1 ATOM 244 C C . ALA A 1 40 ? -23.263 -17.392 -27.681 1.00 28.14 ? 67 ALA A C 1 ATOM 245 O O . ALA A 1 40 ? -22.836 -18.552 -27.748 1.00 26.84 ? 67 ALA A O 1 ATOM 246 C CB . ALA A 1 40 ? -21.912 -15.660 -28.837 1.00 26.18 ? 67 ALA A CB 1 ATOM 247 N N . ALA A 1 41 ? -23.741 -16.853 -26.560 1.00 27.04 ? 68 ALA A N 1 ATOM 248 C CA . ALA A 1 41 ? -23.795 -17.625 -25.324 1.00 27.57 ? 68 ALA A CA 1 ATOM 249 C C . ALA A 1 41 ? -24.840 -18.717 -25.469 1.00 25.82 ? 68 ALA A C 1 ATOM 250 O O . ALA A 1 41 ? -24.617 -19.855 -25.079 1.00 26.22 ? 68 ALA A O 1 ATOM 251 C CB . ALA A 1 41 ? -24.101 -16.724 -24.125 1.00 27.19 ? 68 ALA A CB 1 ATOM 252 N N . ILE A 1 42 ? -25.973 -18.383 -26.063 1.00 24.79 ? 69 ILE A N 1 ATOM 253 C CA . ILE A 1 42 ? -27.019 -19.387 -26.242 1.00 25.80 ? 69 ILE A CA 1 ATOM 254 C C . ILE A 1 42 ? -26.554 -20.493 -27.191 1.00 26.22 ? 69 ILE A C 1 ATOM 255 O O . ILE A 1 42 ? -26.756 -21.682 -26.928 1.00 27.12 ? 69 ILE A O 1 ATOM 256 C CB . ILE A 1 42 ? -28.322 -18.747 -26.748 1.00 25.85 ? 69 ILE A CB 1 ATOM 257 C CG1 . ILE A 1 42 ? -28.922 -17.870 -25.647 1.00 24.99 ? 69 ILE A CG1 1 ATOM 258 C CG2 . ILE A 1 42 ? -29.338 -19.808 -27.159 1.00 25.16 ? 69 ILE A CG2 1 ATOM 259 C CD1 . ILE A 1 42 ? -29.986 -16.929 -26.181 1.00 24.89 ? 69 ILE A CD1 1 ATOM 260 N N . ALA A 1 43 ? -25.931 -20.106 -28.296 1.00 26.22 ? 70 ALA A N 1 ATOM 261 C CA . ALA A 1 43 ? -25.517 -21.093 -29.304 1.00 27.08 ? 70 ALA A CA 1 ATOM 262 C C . ALA A 1 43 ? -24.495 -22.048 -28.696 1.00 26.12 ? 70 ALA A C 1 ATOM 263 O O . ALA A 1 43 ? -24.578 -23.259 -28.876 1.00 25.61 ? 70 ALA A O 1 ATOM 264 C CB . ALA A 1 43 ? -24.912 -20.390 -30.499 1.00 27.52 ? 70 ALA A CB 1 ATOM 265 N N . ALA A 1 44 ? -23.557 -21.482 -27.945 1.00 23.74 ? 71 ALA A N 1 ATOM 266 C CA . ALA A 1 44 ? -22.534 -22.271 -27.271 1.00 24.77 ? 71 ALA A CA 1 ATOM 267 C C . ALA A 1 44 ? -23.107 -23.165 -26.172 1.00 25.28 ? 71 ALA A C 1 ATOM 268 O O . ALA A 1 44 ? -22.728 -24.326 -26.061 1.00 29.29 ? 71 ALA A O 1 ATOM 269 C CB . ALA A 1 44 ? -21.463 -21.350 -26.718 1.00 24.22 ? 71 ALA A CB 1 ATOM 270 N N . LEU A 1 45 ? -24.027 -22.628 -25.375 1.00 24.57 ? 72 LEU A N 1 ATOM 271 C CA . LEU A 1 45 ? -24.696 -23.409 -24.337 1.00 25.49 ? 72 LEU A CA 1 ATOM 272 C C . LEU A 1 45 ? -25.458 -24.598 -24.919 1.00 24.17 ? 72 LEU A C 1 ATOM 273 O O . LEU A 1 45 ? -25.445 -25.683 -24.359 1.00 23.42 ? 72 LEU A O 1 ATOM 274 C CB . LEU A 1 45 ? -25.668 -22.530 -23.501 1.00 25.20 ? 72 LEU A CB 1 ATOM 275 C CG . LEU A 1 45 ? -24.945 -21.563 -22.548 1.00 25.90 ? 72 LEU A CG 1 ATOM 276 C CD1 . LEU A 1 45 ? -25.891 -20.489 -22.058 1.00 27.65 ? 72 LEU A CD1 1 ATOM 277 C CD2 . LEU A 1 45 ? -24.350 -22.302 -21.368 1.00 25.08 ? 72 LEU A CD2 1 ATOM 278 N N . LEU A 1 46 ? -26.113 -24.395 -26.045 1.00 23.99 ? 73 LEU A N 1 ATOM 279 C CA . LEU A 1 46 ? -26.836 -25.494 -26.676 1.00 24.84 ? 73 LEU A CA 1 ATOM 280 C C . LEU A 1 46 ? -25.893 -26.623 -27.064 1.00 23.46 ? 73 LEU A C 1 ATOM 281 O O . LEU A 1 46 ? -26.237 -27.797 -26.960 1.00 22.84 ? 73 LEU A O 1 ATOM 282 C CB . LEU A 1 46 ? -27.593 -25.002 -27.891 1.00 24.95 ? 73 LEU A CB 1 ATOM 283 C CG . LEU A 1 46 ? -28.853 -24.260 -27.542 1.00 25.75 ? 73 LEU A CG 1 ATOM 284 C CD1 . LEU A 1 46 ? -29.261 -23.361 -28.691 1.00 26.35 ? 73 LEU A CD1 1 ATOM 285 C CD2 . LEU A 1 46 ? -29.986 -25.221 -27.184 1.00 26.39 ? 73 LEU A CD2 1 ATOM 286 N N . CYS A 1 47 ? -24.692 -26.248 -27.464 1.00 22.86 ? 74 CYS A N 1 ATOM 287 C CA . CYS A 1 47 ? -23.697 -27.206 -27.860 1.00 24.31 ? 74 CYS A CA 1 ATOM 288 C C . CYS A 1 47 ? -23.089 -27.917 -26.648 1.00 25.05 ? 74 CYS A C 1 ATOM 289 O O . CYS A 1 47 ? -22.773 -29.108 -26.705 1.00 22.28 ? 74 CYS A O 1 ATOM 290 C CB . CYS A 1 47 ? -22.624 -26.502 -28.694 1.00 26.26 ? 74 CYS A CB 1 ATOM 291 S SG . CYS A 1 47 ? -21.120 -27.465 -28.957 1.00 29.35 ? 74 CYS A SG 1 ATOM 292 N N . VAL A 1 48 ? -22.916 -27.191 -25.549 1.00 25.24 ? 75 VAL A N 1 ATOM 293 C CA . VAL A 1 48 ? -22.352 -27.794 -24.346 1.00 24.53 ? 75 VAL A CA 1 ATOM 294 C C . VAL A 1 48 ? -23.308 -28.833 -23.776 1.00 22.72 ? 75 VAL A C 1 ATOM 295 O O . VAL A 1 48 ? -22.904 -29.832 -23.195 1.00 21.00 ? 75 VAL A O 1 ATOM 296 C CB . VAL A 1 48 ? -22.037 -26.728 -23.280 1.00 24.38 ? 75 VAL A CB 1 ATOM 297 C CG1 . VAL A 1 48 ? -21.582 -27.375 -21.988 1.00 24.51 ? 75 VAL A CG1 1 ATOM 298 C CG2 . VAL A 1 48 ? -20.955 -25.790 -23.794 1.00 25.19 ? 75 VAL A CG2 1 ATOM 299 N N . GLY A 1 49 ? -24.584 -28.575 -23.945 1.00 22.69 ? 76 GLY A N 1 ATOM 300 C CA . GLY A 1 49 ? -25.571 -29.503 -23.517 1.00 24.76 ? 76 GLY A CA 1 ATOM 301 C C . GLY A 1 49 ? -25.448 -30.833 -24.229 1.00 25.58 ? 76 GLY A C 1 ATOM 302 O O . GLY A 1 49 ? -25.989 -31.825 -23.747 1.00 26.77 ? 76 GLY A O 1 ATOM 303 N N . LEU A 1 50 ? -24.787 -30.844 -25.388 1.00 25.13 ? 77 LEU A N 1 ATOM 304 C CA . LEU A 1 50 ? -24.571 -32.072 -26.146 1.00 27.44 ? 77 LEU A CA 1 ATOM 305 C C . LEU A 1 50 ? -23.228 -32.719 -25.775 1.00 28.30 ? 77 LEU A C 1 ATOM 306 O O . LEU A 1 50 ? -23.176 -33.874 -25.361 1.00 29.03 ? 77 LEU A O 1 ATOM 307 C CB . LEU A 1 50 ? -24.613 -31.778 -27.644 1.00 27.08 ? 77 LEU A CB 1 ATOM 308 C CG . LEU A 1 50 ? -25.891 -31.133 -28.173 1.00 28.11 ? 77 LEU A CG 1 ATOM 309 C CD1 . LEU A 1 50 ? -25.774 -30.870 -29.661 1.00 28.87 ? 77 LEU A CD1 1 ATOM 310 C CD2 . LEU A 1 50 ? -27.083 -32.034 -27.913 1.00 28.80 ? 77 LEU A CD2 1 ATOM 311 N N . MET A 1 51 ? -22.158 -31.947 -25.899 1.00 28.84 ? 78 MET A N 1 ATOM 312 C CA . MET A 1 51 ? -20.808 -32.439 -25.683 1.00 31.08 ? 78 MET A CA 1 ATOM 313 C C . MET A 1 51 ? -20.527 -32.732 -24.240 1.00 31.33 ? 78 MET A C 1 ATOM 314 O O . MET A 1 51 ? -19.783 -33.658 -23.941 1.00 33.36 ? 78 MET A O 1 ATOM 315 C CB . MET A 1 51 ? -19.820 -31.414 -26.218 1.00 35.74 ? 78 MET A CB 1 ATOM 316 C CG . MET A 1 51 ? -20.086 -31.146 -27.696 1.00 38.66 ? 78 MET A CG 1 ATOM 317 S SD . MET A 1 51 ? -18.713 -30.540 -28.645 1.00 48.38 ? 78 MET A SD 1 ATOM 318 C CE . MET A 1 51 ? -18.102 -32.081 -29.257 1.00 48.95 ? 78 MET A CE 1 ATOM 319 N N . ASN A 1 52 ? -21.131 -31.959 -23.332 1.00 29.09 ? 79 ASN A N 1 ATOM 320 C CA . ASN A 1 52 ? -21.008 -32.246 -21.914 1.00 28.15 ? 79 ASN A CA 1 ATOM 321 C C . ASN A 1 52 ? -22.365 -32.457 -21.290 1.00 27.94 ? 79 ASN A C 1 ATOM 322 O O . ASN A 1 52 ? -22.744 -31.791 -20.332 1.00 30.07 ? 79 ASN A O 1 ATOM 323 C CB . ASN A 1 52 ? -20.209 -31.151 -21.228 1.00 27.64 ? 79 ASN A CB 1 ATOM 324 C CG . ASN A 1 52 ? -18.742 -31.190 -21.623 1.00 28.01 ? 79 ASN A CG 1 ATOM 325 O OD1 . ASN A 1 52 ? -18.088 -32.224 -21.525 1.00 27.18 ? 79 ASN A OD1 1 ATOM 326 N ND2 . ASN A 1 52 ? -18.222 -30.072 -22.066 1.00 31.71 ? 79 ASN A ND2 1 ATOM 327 N N . ALA A 1 53 ? -23.096 -33.405 -21.845 1.00 25.22 ? 80 ALA A N 1 ATOM 328 C CA . ALA A 1 53 ? -24.489 -33.624 -21.467 1.00 26.85 ? 80 ALA A CA 1 ATOM 329 C C . ALA A 1 53 ? -24.642 -34.032 -20.010 1.00 25.81 ? 80 ALA A C 1 ATOM 330 O O . ALA A 1 53 ? -25.718 -33.897 -19.433 1.00 24.88 ? 80 ALA A O 1 ATOM 331 C CB . ALA A 1 53 ? -25.131 -34.665 -22.387 1.00 27.70 ? 80 ALA A CB 1 ATOM 332 N N . HIS A 1 54 ? -23.570 -34.541 -19.414 1.00 25.48 ? 81 HIS A N 1 ATOM 333 C CA . HIS A 1 54 ? -23.582 -34.820 -17.991 1.00 26.90 ? 81 HIS A CA 1 ATOM 334 C C . HIS A 1 54 ? -23.678 -33.568 -17.074 1.00 25.35 ? 81 HIS A C 1 ATOM 335 O O . HIS A 1 54 ? -24.087 -33.702 -15.932 1.00 23.81 ? 81 HIS A O 1 ATOM 336 C CB . HIS A 1 54 ? -22.345 -35.645 -17.600 1.00 25.72 ? 81 HIS A CB 1 ATOM 337 C CG . HIS A 1 54 ? -21.075 -34.880 -17.702 1.00 26.52 ? 81 HIS A CG 1 ATOM 338 N ND1 . HIS A 1 54 ? -20.589 -34.404 -18.901 1.00 26.53 ? 81 HIS A ND1 1 ATOM 339 C CD2 . HIS A 1 54 ? -20.196 -34.486 -16.753 1.00 26.65 ? 81 HIS A CD2 1 ATOM 340 C CE1 . HIS A 1 54 ? -19.463 -33.751 -18.684 1.00 27.51 ? 81 HIS A CE1 1 ATOM 341 N NE2 . HIS A 1 54 ? -19.200 -33.791 -17.390 1.00 27.69 ? 81 HIS A NE2 1 ATOM 342 N N . SER A 1 55 ? -23.297 -32.400 -17.591 1.00 24.25 ? 82 SER A N 1 ATOM 343 C CA . SER A 1 55 ? -23.110 -31.147 -16.837 1.00 24.99 ? 82 SER A CA 1 ATOM 344 C C . SER A 1 55 ? -24.290 -30.193 -16.847 1.00 24.83 ? 82 SER A C 1 ATOM 345 O O . SER A 1 55 ? -24.512 -29.460 -15.900 1.00 24.78 ? 82 SER A O 1 ATOM 346 C CB . SER A 1 55 ? -21.982 -30.323 -17.480 1.00 25.96 ? 82 SER A CB 1 ATOM 347 O OG . SER A 1 55 ? -20.794 -31.048 -17.470 1.00 31.97 ? 82 SER A OG 1 ATOM 348 N N . MET A 1 56 ? -24.966 -30.107 -17.972 1.00 24.30 ? 83 MET A N 1 ATOM 349 C CA . MET A 1 56 ? -25.963 -29.056 -18.185 1.00 23.71 ? 83 MET A CA 1 ATOM 350 C C . MET A 1 56 ? -26.771 -29.394 -19.395 1.00 23.40 ? 83 MET A C 1 ATOM 351 O O . MET A 1 56 ? -26.353 -30.262 -20.200 1.00 21.75 ? 83 MET A O 1 ATOM 352 C CB . MET A 1 56 ? -25.292 -27.715 -18.442 1.00 24.32 ? 83 MET A CB 1 ATOM 353 C CG . MET A 1 56 ? -24.492 -27.656 -19.734 1.00 25.32 ? 83 MET A CG 1 ATOM 354 S SD . MET A 1 56 ? -24.387 -26.000 -20.430 1.00 26.65 ? 83 MET A SD 1 ATOM 355 C CE . MET A 1 56 ? -26.051 -25.830 -21.030 1.00 24.53 ? 83 MET A CE 1 ATOM 356 N N . GLY A 1 57 ? -27.905 -28.695 -19.544 1.00 23.48 ? 84 GLY A N 1 ATOM 357 C CA . GLY A 1 57 ? -28.705 -28.789 -20.764 1.00 22.03 ? 84 GLY A CA 1 ATOM 358 C C . GLY A 1 57 ? -30.139 -28.323 -20.634 1.00 23.09 ? 84 GLY A C 1 ATOM 359 O O . GLY A 1 57 ? -30.502 -27.675 -19.654 1.00 23.22 ? 84 GLY A O 1 ATOM 360 N N . ILE A 1 58 ? -30.966 -28.646 -21.633 1.00 21.82 ? 85 ILE A N 1 ATOM 361 C CA . ILE A 1 58 ? -32.345 -28.141 -21.681 1.00 22.60 ? 85 ILE A CA 1 ATOM 362 C C . ILE A 1 58 ? -33.240 -28.822 -20.637 1.00 22.06 ? 85 ILE A C 1 ATOM 363 O O . ILE A 1 58 ? -34.381 -28.399 -20.412 1.00 24.91 ? 85 ILE A O 1 ATOM 364 C CB . ILE A 1 58 ? -32.963 -28.199 -23.111 1.00 22.90 ? 85 ILE A CB 1 ATOM 365 C CG1 . ILE A 1 58 ? -33.089 -29.633 -23.614 1.00 23.31 ? 85 ILE A CG1 1 ATOM 366 C CG2 . ILE A 1 58 ? -32.087 -27.387 -24.073 1.00 23.11 ? 85 ILE A CG2 1 ATOM 367 C CD1 . ILE A 1 58 ? -33.971 -29.768 -24.820 1.00 24.69 ? 85 ILE A CD1 1 ATOM 368 N N . GLY A 1 59 ? -32.701 -29.806 -19.934 1.00 20.54 ? 86 GLY A N 1 ATOM 369 C CA . GLY A 1 59 ? -33.421 -30.419 -18.837 1.00 19.98 ? 86 GLY A CA 1 ATOM 370 C C . GLY A 1 59 ? -33.092 -29.789 -17.507 1.00 19.80 ? 86 GLY A C 1 ATOM 371 O O . GLY A 1 59 ? -33.542 -30.289 -16.469 1.00 19.74 ? 86 GLY A O 1 ATOM 372 N N . GLY A 1 60 ? -32.277 -28.727 -17.522 1.00 20.53 ? 87 GLY A N 1 ATOM 373 C CA . GLY A 1 60 ? -31.852 -28.037 -16.302 1.00 21.06 ? 87 GLY A CA 1 ATOM 374 C C . GLY A 1 60 ? -32.226 -26.564 -16.185 1.00 21.29 ? 87 GLY A C 1 ATOM 375 O O . GLY A 1 60 ? -33.307 -26.164 -16.561 1.00 19.61 ? 87 GLY A O 1 ATOM 376 N N . GLY A 1 61 ? -31.331 -25.764 -15.605 1.00 22.20 ? 88 GLY A N 1 ATOM 377 C CA . GLY A 1 61 ? -31.603 -24.339 -15.388 1.00 22.58 ? 88 GLY A CA 1 ATOM 378 C C . GLY A 1 61 ? -30.316 -23.555 -15.396 1.00 22.42 ? 88 GLY A C 1 ATOM 379 O O . GLY A 1 61 ? -29.255 -24.143 -15.288 1.00 23.22 ? 88 GLY A O 1 ATOM 380 N N . LEU A 1 62 ? -30.400 -22.236 -15.546 1.00 23.48 ? 89 LEU A N 1 ATOM 381 C CA . LEU A 1 62 ? -29.206 -21.409 -15.528 1.00 25.12 ? 89 LEU A CA 1 ATOM 382 C C . LEU A 1 62 ? -29.427 -19.975 -15.047 1.00 24.64 ? 89 LEU A C 1 ATOM 383 O O . LEU A 1 62 ? -30.543 -19.529 -14.889 1.00 26.81 ? 89 LEU A O 1 ATOM 384 C CB . LEU A 1 62 ? -28.539 -21.403 -16.902 1.00 25.73 ? 89 LEU A CB 1 ATOM 385 C CG . LEU A 1 62 ? -29.041 -20.361 -17.938 1.00 25.97 ? 89 LEU A CG 1 ATOM 386 C CD1 . LEU A 1 62 ? -28.035 -20.185 -19.042 1.00 26.27 ? 89 LEU A CD1 1 ATOM 387 C CD2 . LEU A 1 62 ? -30.357 -20.772 -18.514 1.00 25.91 ? 89 LEU A CD2 1 ATOM 388 N N . PHE A 1 63 ? -28.313 -19.308 -14.779 1.00 24.08 ? 90 PHE A N 1 ATOM 389 C CA . PHE A 1 63 ? -28.254 -17.880 -14.569 1.00 23.77 ? 90 PHE A CA 1 ATOM 390 C C . PHE A 1 63 ? -27.307 -17.251 -15.606 1.00 23.35 ? 90 PHE A C 1 ATOM 391 O O . PHE A 1 63 ? -26.261 -17.820 -15.948 1.00 23.50 ? 90 PHE A O 1 ATOM 392 C CB . PHE A 1 63 ? -27.744 -17.579 -13.166 1.00 23.97 ? 90 PHE A CB 1 ATOM 393 C CG . PHE A 1 63 ? -28.828 -17.298 -12.154 1.00 23.73 ? 90 PHE A CG 1 ATOM 394 C CD1 . PHE A 1 63 ? -29.698 -18.300 -11.733 1.00 23.86 ? 90 PHE A CD1 1 ATOM 395 C CD2 . PHE A 1 63 ? -28.931 -16.046 -11.572 1.00 24.42 ? 90 PHE A CD2 1 ATOM 396 C CE1 . PHE A 1 63 ? -30.680 -18.034 -10.782 1.00 23.86 ? 90 PHE A CE1 1 ATOM 397 C CE2 . PHE A 1 63 ? -29.888 -15.783 -10.601 1.00 23.90 ? 90 PHE A CE2 1 ATOM 398 C CZ . PHE A 1 63 ? -30.757 -16.782 -10.201 1.00 24.17 ? 90 PHE A CZ 1 ATOM 399 N N . LEU A 1 64 ? -27.702 -16.099 -16.129 1.00 23.44 ? 91 LEU A N 1 ATOM 400 C CA . LEU A 1 64 ? -26.838 -15.292 -16.989 1.00 25.65 ? 91 LEU A CA 1 ATOM 401 C C . LEU A 1 64 ? -26.641 -13.936 -16.320 1.00 25.68 ? 91 LEU A C 1 ATOM 402 O O . LEU A 1 64 ? -27.611 -13.322 -15.867 1.00 26.70 ? 91 LEU A O 1 ATOM 403 C CB . LEU A 1 64 ? -27.452 -15.076 -18.371 1.00 26.78 ? 91 LEU A CB 1 ATOM 404 C CG . LEU A 1 64 ? -27.895 -16.347 -19.076 1.00 29.30 ? 91 LEU A CG 1 ATOM 405 C CD1 . LEU A 1 64 ? -29.390 -16.534 -18.871 1.00 30.09 ? 91 LEU A CD1 1 ATOM 406 C CD2 . LEU A 1 64 ? -27.579 -16.307 -20.567 1.00 30.59 ? 91 LEU A CD2 1 ATOM 407 N N . THR A 1 65 ? -25.382 -13.533 -16.187 1.00 25.35 ? 92 THR A N 1 ATOM 408 C CA . THR A 1 65 ? -25.021 -12.170 -15.831 1.00 24.58 ? 92 THR A CA 1 ATOM 409 C C . THR A 1 65 ? -24.641 -11.505 -17.159 1.00 24.24 ? 92 THR A C 1 ATOM 410 O O . THR A 1 65 ? -23.788 -12.010 -17.871 1.00 26.01 ? 92 THR A O 1 ATOM 411 C CB . THR A 1 65 ? -23.871 -12.163 -14.797 1.00 25.06 ? 92 THR A CB 1 ATOM 412 O OG1 . THR A 1 65 ? -24.284 -12.871 -13.608 1.00 23.20 ? 92 THR A OG1 1 ATOM 413 C CG2 . THR A 1 65 ? -23.465 -10.749 -14.421 1.00 25.80 ? 92 THR A CG2 1 ATOM 414 N N . ILE A 1 66 ? -25.318 -10.418 -17.505 1.00 23.79 ? 93 ILE A N 1 ATOM 415 C CA . ILE A 1 66 ? -25.165 -9.743 -18.800 1.00 25.34 ? 93 ILE A CA 1 ATOM 416 C C . ILE A 1 66 ? -24.773 -8.272 -18.599 1.00 26.71 ? 93 ILE A C 1 ATOM 417 O O . ILE A 1 66 ? -25.420 -7.549 -17.828 1.00 26.60 ? 93 ILE A O 1 ATOM 418 C CB . ILE A 1 66 ? -26.495 -9.841 -19.590 1.00 27.00 ? 93 ILE A CB 1 ATOM 419 C CG1 . ILE A 1 66 ? -26.904 -11.307 -19.710 1.00 27.14 ? 93 ILE A CG1 1 ATOM 420 C CG2 . ILE A 1 66 ? -26.381 -9.221 -20.982 1.00 27.89 ? 93 ILE A CG2 1 ATOM 421 C CD1 . ILE A 1 66 ? -28.312 -11.516 -20.210 1.00 27.64 ? 93 ILE A CD1 1 ATOM 422 N N . TYR A 1 67 ? -23.705 -7.837 -19.269 1.00 27.06 ? 94 TYR A N 1 ATOM 423 C CA . TYR A 1 67 ? -23.283 -6.440 -19.227 1.00 28.97 ? 94 TYR A CA 1 ATOM 424 C C . TYR A 1 67 ? -23.395 -5.790 -20.609 1.00 30.87 ? 94 TYR A C 1 ATOM 425 O O . TYR A 1 67 ? -22.864 -6.295 -21.621 1.00 28.42 ? 94 TYR A O 1 ATOM 426 C CB . TYR A 1 67 ? -21.845 -6.294 -18.726 1.00 29.40 ? 94 TYR A CB 1 ATOM 427 C CG . TYR A 1 67 ? -21.367 -4.850 -18.687 1.00 29.85 ? 94 TYR A CG 1 ATOM 428 C CD1 . TYR A 1 67 ? -21.874 -3.955 -17.741 1.00 31.81 ? 94 TYR A CD1 1 ATOM 429 C CD2 . TYR A 1 67 ? -20.444 -4.373 -19.617 1.00 29.59 ? 94 TYR A CD2 1 ATOM 430 C CE1 . TYR A 1 67 ? -21.465 -2.635 -17.700 1.00 31.09 ? 94 TYR A CE1 1 ATOM 431 C CE2 . TYR A 1 67 ? -20.012 -3.066 -19.586 1.00 30.33 ? 94 TYR A CE2 1 ATOM 432 C CZ . TYR A 1 67 ? -20.524 -2.196 -18.625 1.00 33.63 ? 94 TYR A CZ 1 ATOM 433 O OH . TYR A 1 67 ? -20.118 -0.890 -18.608 1.00 31.56 ? 94 TYR A OH 1 ATOM 434 N N . ASN A 1 68 ? -24.097 -4.668 -20.640 1.00 34.31 ? 95 ASN A N 1 ATOM 435 C CA . ASN A 1 68 ? -24.286 -3.906 -21.870 1.00 38.57 ? 95 ASN A CA 1 ATOM 436 C C . ASN A 1 68 ? -23.322 -2.731 -21.903 1.00 35.10 ? 95 ASN A C 1 ATOM 437 O O . ASN A 1 68 ? -23.433 -1.827 -21.077 1.00 35.08 ? 95 ASN A O 1 ATOM 438 C CB . ASN A 1 68 ? -25.722 -3.415 -21.956 1.00 47.11 ? 95 ASN A CB 1 ATOM 439 C CG . ASN A 1 68 ? -26.027 -2.713 -23.272 1.00 55.43 ? 95 ASN A CG 1 ATOM 440 O OD1 . ASN A 1 68 ? -25.176 -2.008 -23.846 1.00 51.09 ? 95 ASN A OD1 1 ATOM 441 N ND2 . ASN A 1 68 ? -27.256 -2.911 -23.758 1.00 67.83 ? 95 ASN A ND2 1 ATOM 442 N N . SER A 1 69 ? -22.389 -2.767 -22.855 1.00 34.48 ? 96 SER A N 1 ATOM 443 C CA A SER A 1 69 ? -21.310 -1.771 -23.012 0.50 35.24 ? 96 SER A CA 1 ATOM 444 C CA B SER A 1 69 ? -21.326 -1.758 -22.911 0.50 37.26 ? 96 SER A CA 1 ATOM 445 C C . SER A 1 69 ? -21.803 -0.354 -23.309 1.00 37.81 ? 96 SER A C 1 ATOM 446 O O . SER A 1 69 ? -21.126 0.630 -23.010 1.00 40.58 ? 96 SER A O 1 ATOM 447 C CB A SER A 1 69 ? -20.421 -2.181 -24.180 0.50 32.05 ? 96 SER A CB 1 ATOM 448 C CB B SER A 1 69 ? -20.205 -2.187 -23.844 0.50 36.14 ? 96 SER A CB 1 ATOM 449 O OG A SER A 1 69 ? -21.193 -2.276 -25.366 0.50 30.63 ? 96 SER A OG 1 ATOM 450 O OG B SER A 1 69 ? -18.977 -1.763 -23.289 0.50 39.40 ? 96 SER A OG 1 ATOM 451 N N . THR A 1 70 ? -22.960 -0.272 -23.953 1.00 40.36 ? 97 THR A N 1 ATOM 452 C CA . THR A 1 70 ? -23.564 1.008 -24.356 1.00 45.31 ? 97 THR A CA 1 ATOM 453 C C . THR A 1 70 ? -24.216 1.725 -23.166 1.00 43.11 ? 97 THR A C 1 ATOM 454 O O . THR A 1 70 ? -23.804 2.818 -22.803 1.00 45.11 ? 97 THR A O 1 ATOM 455 C CB . THR A 1 70 ? -24.635 0.780 -25.455 1.00 44.64 ? 97 THR A CB 1 ATOM 456 O OG1 . THR A 1 70 ? -24.030 0.118 -26.568 1.00 44.69 ? 97 THR A OG1 1 ATOM 457 C CG2 . THR A 1 70 ? -25.261 2.082 -25.904 1.00 47.62 ? 97 THR A CG2 1 ATOM 458 N N . THR A 1 71 ? -25.213 1.090 -22.553 1.00 39.80 ? 98 THR A N 1 ATOM 459 C CA . THR A 1 71 ? -25.891 1.652 -21.390 1.00 36.26 ? 98 THR A CA 1 ATOM 460 C C . THR A 1 71 ? -25.084 1.585 -20.091 1.00 36.73 ? 98 THR A C 1 ATOM 461 O O . THR A 1 71 ? -25.476 2.178 -19.088 1.00 33.54 ? 98 THR A O 1 ATOM 462 C CB . THR A 1 71 ? -27.167 0.882 -21.125 1.00 38.25 ? 98 THR A CB 1 ATOM 463 O OG1 . THR A 1 71 ? -26.831 -0.472 -20.796 1.00 40.89 ? 98 THR A OG1 1 ATOM 464 C CG2 . THR A 1 71 ? -28.056 0.905 -22.360 1.00 40.05 ? 98 THR A CG2 1 ATOM 465 N N . ARG A 1 72 ? -23.979 0.835 -20.113 1.00 37.59 ? 99 ARG A N 1 ATOM 466 C CA . ARG A 1 72 ? -23.125 0.579 -18.944 1.00 38.62 ? 99 ARG A CA 1 ATOM 467 C C . ARG A 1 72 ? -23.861 -0.031 -17.765 1.00 35.67 ? 99 ARG A C 1 ATOM 468 O O . ARG A 1 72 ? -23.520 0.223 -16.619 1.00 37.92 ? 99 ARG A O 1 ATOM 469 C CB . ARG A 1 72 ? -22.372 1.837 -18.521 1.00 42.62 ? 99 ARG A CB 1 ATOM 470 C CG . ARG A 1 72 ? -21.369 2.247 -19.569 1.00 49.62 ? 99 ARG A CG 1 ATOM 471 C CD . ARG A 1 72 ? -20.575 3.428 -19.107 1.00 53.08 ? 99 ARG A CD 1 ATOM 472 N NE . ARG A 1 72 ? -19.661 3.867 -20.147 1.00 59.38 ? 99 ARG A NE 1 ATOM 473 C CZ . ARG A 1 72 ? -18.742 4.808 -19.969 1.00 67.89 ? 99 ARG A CZ 1 ATOM 474 N NH1 . ARG A 1 72 ? -18.611 5.409 -18.785 1.00 67.89 ? 99 ARG A NH1 1 ATOM 475 N NH2 . ARG A 1 72 ? -17.947 5.146 -20.978 1.00 70.85 ? 99 ARG A NH2 1 ATOM 476 N N . LYS A 1 73 ? -24.840 -0.865 -18.065 1.00 35.54 ? 100 LYS A N 1 ATOM 477 C CA . LYS A 1 73 ? -25.639 -1.511 -17.055 1.00 38.62 ? 100 LYS A CA 1 ATOM 478 C C . LYS A 1 73 ? -25.486 -2.995 -17.161 1.00 34.34 ? 100 LYS A C 1 ATOM 479 O O . LYS A 1 73 ? -25.280 -3.544 -18.253 1.00 30.67 ? 100 LYS A O 1 ATOM 480 C CB . LYS A 1 73 ? -27.100 -1.125 -17.223 1.00 47.97 ? 100 LYS A CB 1 ATOM 481 C CG . LYS A 1 73 ? -27.374 0.346 -16.937 1.00 58.20 ? 100 LYS A CG 1 ATOM 482 C CD . LYS A 1 73 ? -28.862 0.680 -17.018 1.00 70.08 ? 100 LYS A CD 1 ATOM 483 C CE . LYS A 1 73 ? -29.203 2.118 -16.621 1.00 78.11 ? 100 LYS A CE 1 ATOM 484 N NZ . LYS A 1 73 ? -28.751 3.129 -17.619 1.00 83.36 ? 100 LYS A NZ 1 ATOM 485 N N . ALA A 1 74 ? -25.570 -3.631 -16.001 1.00 31.65 ? 101 ALA A N 1 ATOM 486 C CA . ALA A 1 74 ? -25.529 -5.063 -15.886 1.00 29.57 ? 101 ALA A CA 1 ATOM 487 C C . ALA A 1 74 ? -26.883 -5.545 -15.494 1.00 29.77 ? 101 ALA A C 1 ATOM 488 O O . ALA A 1 74 ? -27.588 -4.895 -14.711 1.00 29.86 ? 101 ALA A O 1 ATOM 489 C CB . ALA A 1 74 ? -24.553 -5.477 -14.817 1.00 31.65 ? 101 ALA A CB 1 ATOM 490 N N . GLU A 1 75 ? -27.239 -6.716 -15.992 1.00 28.16 ? 102 GLU A N 1 ATOM 491 C CA . GLU A 1 75 ? -28.425 -7.373 -15.503 1.00 29.09 ? 102 GLU A CA 1 ATOM 492 C C . GLU A 1 75 ? -28.137 -8.843 -15.262 1.00 27.12 ? 102 GLU A C 1 ATOM 493 O O . GLU A 1 75 ? -27.103 -9.367 -15.703 1.00 25.61 ? 102 GLU A O 1 ATOM 494 C CB . GLU A 1 75 ? -29.583 -7.179 -16.475 1.00 29.65 ? 102 GLU A CB 1 ATOM 495 C CG . GLU A 1 75 ? -29.379 -7.862 -17.817 1.00 33.43 ? 102 GLU A CG 1 ATOM 496 C CD . GLU A 1 75 ? -30.440 -7.480 -18.851 1.00 37.80 ? 102 GLU A CD 1 ATOM 497 O OE1 . GLU A 1 75 ? -30.675 -6.275 -19.025 1.00 39.38 ? 102 GLU A OE1 1 ATOM 498 O OE2 . GLU A 1 75 ? -31.047 -8.380 -19.487 1.00 37.44 ? 102 GLU A OE2 1 ATOM 499 N N . VAL A 1 76 ? -29.057 -9.474 -14.540 1.00 25.82 ? 103 VAL A N 1 ATOM 500 C CA . VAL A 1 76 ? -29.051 -10.908 -14.313 1.00 26.68 ? 103 VAL A CA 1 ATOM 501 C C . VAL A 1 76 ? -30.353 -11.533 -14.809 1.00 26.43 ? 103 VAL A C 1 ATOM 502 O O . VAL A 1 76 ? -31.446 -10.962 -14.616 1.00 26.94 ? 103 VAL A O 1 ATOM 503 C CB . VAL A 1 76 ? -28.830 -11.224 -12.833 1.00 26.53 ? 103 VAL A CB 1 ATOM 504 C CG1 . VAL A 1 76 ? -29.210 -12.659 -12.483 1.00 27.03 ? 103 VAL A CG1 1 ATOM 505 C CG2 . VAL A 1 76 ? -27.376 -11.002 -12.519 1.00 27.02 ? 103 VAL A CG2 1 ATOM 506 N N . ILE A 1 77 ? -30.237 -12.674 -15.485 1.00 24.94 ? 104 ILE A N 1 ATOM 507 C CA . ILE A 1 77 ? -31.416 -13.487 -15.783 1.00 25.80 ? 104 ILE A CA 1 ATOM 508 C C . ILE A 1 77 ? -31.392 -14.763 -14.964 1.00 24.73 ? 104 ILE A C 1 ATOM 509 O O . ILE A 1 77 ? -30.476 -15.570 -15.088 1.00 23.68 ? 104 ILE A O 1 ATOM 510 C CB . ILE A 1 77 ? -31.536 -13.786 -17.270 1.00 27.86 ? 104 ILE A CB 1 ATOM 511 C CG1 . ILE A 1 77 ? -31.907 -12.476 -17.985 1.00 31.06 ? 104 ILE A CG1 1 ATOM 512 C CG2 . ILE A 1 77 ? -32.607 -14.841 -17.546 1.00 27.13 ? 104 ILE A CG2 1 ATOM 513 C CD1 . ILE A 1 77 ? -31.610 -12.538 -19.444 1.00 34.29 ? 104 ILE A CD1 1 ATOM 514 N N . ASN A 1 78 ? -32.436 -14.911 -14.147 1.00 23.96 ? 105 ASN A N 1 ATOM 515 C CA . ASN A 1 78 ? -32.678 -16.065 -13.312 1.00 22.67 ? 105 ASN A CA 1 ATOM 516 C C . ASN A 1 78 ? -33.576 -17.041 -14.042 1.00 23.69 ? 105 ASN A C 1 ATOM 517 O O . ASN A 1 78 ? -34.797 -16.814 -14.182 1.00 24.02 ? 105 ASN A O 1 ATOM 518 C CB . ASN A 1 78 ? -33.344 -15.610 -12.020 1.00 22.69 ? 105 ASN A CB 1 ATOM 519 C CG . ASN A 1 78 ? -33.825 -16.773 -11.152 1.00 24.01 ? 105 ASN A CG 1 ATOM 520 O OD1 . ASN A 1 78 ? -33.839 -17.937 -11.576 1.00 21.56 ? 105 ASN A OD1 1 ATOM 521 N ND2 . ASN A 1 78 ? -34.259 -16.443 -9.920 1.00 23.97 ? 105 ASN A ND2 1 ATOM 522 N N . ALA A 1 79 ? -32.975 -18.141 -14.493 1.00 23.85 ? 106 ALA A N 1 ATOM 523 C CA . ALA A 1 79 ? -33.728 -19.222 -15.101 1.00 23.92 ? 106 ALA A CA 1 ATOM 524 C C . ALA A 1 79 ? -33.389 -20.562 -14.432 1.00 22.30 ? 106 ALA A C 1 ATOM 525 O O . ALA A 1 79 ? -33.303 -21.615 -15.073 1.00 22.91 ? 106 ALA A O 1 ATOM 526 C CB . ALA A 1 79 ? -33.480 -19.259 -16.590 1.00 22.88 ? 106 ALA A CB 1 ATOM 527 N N . ARG A 1 80 ? -33.264 -20.517 -13.129 1.00 21.71 ? 107 ARG A N 1 ATOM 528 C CA . ARG A 1 80 ? -32.992 -21.721 -12.363 1.00 21.78 ? 107 ARG A CA 1 ATOM 529 C C . ARG A 1 80 ? -34.296 -22.472 -12.102 1.00 21.73 ? 107 ARG A C 1 ATOM 530 O O . ARG A 1 80 ? -35.384 -21.867 -12.048 1.00 22.04 ? 107 ARG A O 1 ATOM 531 C CB . ARG A 1 80 ? -32.283 -21.357 -11.068 1.00 21.51 ? 107 ARG A CB 1 ATOM 532 C CG . ARG A 1 80 ? -32.045 -22.517 -10.089 1.00 22.48 ? 107 ARG A CG 1 ATOM 533 C CD . ARG A 1 80 ? -30.893 -22.158 -9.174 1.00 22.59 ? 107 ARG A CD 1 ATOM 534 N NE . ARG A 1 80 ? -30.592 -23.099 -8.092 1.00 22.99 ? 107 ARG A NE 1 ATOM 535 C CZ . ARG A 1 80 ? -29.793 -24.155 -8.179 1.00 23.36 ? 107 ARG A CZ 1 ATOM 536 N NH1 . ARG A 1 80 ? -29.242 -24.508 -9.318 1.00 22.19 ? 107 ARG A NH1 1 ATOM 537 N NH2 . ARG A 1 80 ? -29.568 -24.888 -7.102 1.00 25.47 ? 107 ARG A NH2 1 ATOM 538 N N . GLU A 1 81 ? -34.179 -23.787 -11.957 1.00 21.56 ? 108 GLU A N 1 ATOM 539 C CA . GLU A 1 81 ? -35.345 -24.645 -11.738 1.00 24.09 ? 108 GLU A CA 1 ATOM 540 C C . GLU A 1 81 ? -36.070 -24.279 -10.453 1.00 24.06 ? 108 GLU A C 1 ATOM 541 O O . GLU A 1 81 ? -35.450 -23.740 -9.538 1.00 24.29 ? 108 GLU A O 1 ATOM 542 C CB . GLU A 1 81 ? -34.947 -26.125 -11.684 1.00 25.49 ? 108 GLU A CB 1 ATOM 543 C CG . GLU A 1 81 ? -34.089 -26.601 -12.837 1.00 24.72 ? 108 GLU A CG 1 ATOM 544 C CD . GLU A 1 81 ? -32.612 -26.633 -12.514 1.00 26.21 ? 108 GLU A CD 1 ATOM 545 O OE1 . GLU A 1 81 ? -32.074 -25.570 -12.069 1.00 27.47 ? 108 GLU A OE1 1 ATOM 546 O OE2 . GLU A 1 81 ? -31.984 -27.716 -12.722 1.00 25.65 ? 108 GLU A OE2 1 ATOM 547 N N . VAL A 1 82 ? -37.381 -24.562 -10.404 1.00 24.29 ? 109 VAL A N 1 ATOM 548 C CA . VAL A 1 82 ? -38.206 -24.363 -9.199 1.00 24.07 ? 109 VAL A CA 1 ATOM 549 C C . VAL A 1 82 ? -38.821 -25.675 -8.790 1.00 23.20 ? 109 VAL A C 1 ATOM 550 O O . VAL A 1 82 ? -39.110 -26.519 -9.614 1.00 25.68 ? 109 VAL A O 1 ATOM 551 C CB . VAL A 1 82 ? -39.409 -23.401 -9.403 1.00 25.17 ? 109 VAL A CB 1 ATOM 552 C CG1 . VAL A 1 82 ? -38.951 -21.994 -9.571 1.00 27.45 ? 109 VAL A CG1 1 ATOM 553 C CG2 . VAL A 1 82 ? -40.262 -23.804 -10.615 1.00 25.73 ? 109 VAL A CG2 1 ATOM 554 N N . ALA A 1 83 ? -39.103 -25.803 -7.519 1.00 23.54 ? 110 ALA A N 1 ATOM 555 C CA . ALA A 1 83 ? -39.800 -26.959 -7.018 1.00 25.06 ? 110 ALA A CA 1 ATOM 556 C C . ALA A 1 83 ? -41.212 -26.998 -7.615 1.00 24.81 ? 110 ALA A C 1 ATOM 557 O O . ALA A 1 83 ? -41.885 -25.985 -7.699 1.00 24.13 ? 110 ALA A O 1 ATOM 558 C CB . ALA A 1 83 ? -39.874 -26.897 -5.508 1.00 24.96 ? 110 ALA A CB 1 ATOM 559 N N . PRO A 1 84 ? -41.654 -28.165 -8.028 1.00 24.00 ? 111 PRO A N 1 ATOM 560 C CA . PRO A 1 84 ? -42.993 -28.269 -8.587 1.00 25.54 ? 111 PRO A CA 1 ATOM 561 C C . PRO A 1 84 ? -44.081 -27.914 -7.557 1.00 27.75 ? 111 PRO A C 1 ATOM 562 O O . PRO A 1 84 ? -43.818 -27.911 -6.349 1.00 27.92 ? 111 PRO A O 1 ATOM 563 C CB . PRO A 1 84 ? -43.106 -29.733 -9.012 1.00 26.80 ? 111 PRO A CB 1 ATOM 564 C CG . PRO A 1 84 ? -41.826 -30.407 -8.683 1.00 25.73 ? 111 PRO A CG 1 ATOM 565 C CD . PRO A 1 84 ? -40.900 -29.420 -8.042 1.00 25.01 ? 111 PRO A CD 1 ATOM 566 N N . ARG A 1 85 ? -45.279 -27.605 -8.033 1.00 27.12 ? 112 ARG A N 1 ATOM 567 C CA . ARG A 1 85 ? -46.359 -27.123 -7.171 1.00 29.88 ? 112 ARG A CA 1 ATOM 568 C C . ARG A 1 85 ? -46.827 -28.168 -6.134 1.00 27.12 ? 112 ARG A C 1 ATOM 569 O O . ARG A 1 85 ? -47.388 -27.803 -5.091 1.00 27.79 ? 112 ARG A O 1 ATOM 570 C CB . ARG A 1 85 ? -47.553 -26.603 -8.019 1.00 33.30 ? 112 ARG A CB 1 ATOM 571 C CG . ARG A 1 85 ? -48.331 -27.734 -8.693 1.00 40.07 ? 112 ARG A CG 1 ATOM 572 C CD . ARG A 1 85 ? -49.491 -27.321 -9.609 1.00 44.84 ? 112 ARG A CD 1 ATOM 573 N NE . ARG A 1 85 ? -50.067 -28.543 -10.214 1.00 49.31 ? 112 ARG A NE 1 ATOM 574 C CZ . ARG A 1 85 ? -51.105 -29.234 -9.715 1.00 53.97 ? 112 ARG A CZ 1 ATOM 575 N NH1 . ARG A 1 85 ? -51.717 -28.830 -8.590 1.00 54.68 ? 112 ARG A NH1 1 ATOM 576 N NH2 . ARG A 1 85 ? -51.546 -30.338 -10.343 1.00 49.30 ? 112 ARG A NH2 1 ATOM 577 N N . LEU A 1 86 ? -46.579 -29.442 -6.414 1.00 25.04 ? 113 LEU A N 1 ATOM 578 C CA . LEU A 1 86 ? -46.968 -30.525 -5.522 1.00 26.06 ? 113 LEU A CA 1 ATOM 579 C C . LEU A 1 86 ? -45.869 -30.910 -4.571 1.00 26.62 ? 113 LEU A C 1 ATOM 580 O O . LEU A 1 86 ? -46.063 -31.822 -3.762 1.00 24.78 ? 113 LEU A O 1 ATOM 581 C CB . LEU A 1 86 ? -47.387 -31.778 -6.311 1.00 25.39 ? 113 LEU A CB 1 ATOM 582 C CG . LEU A 1 86 ? -48.618 -31.604 -7.209 1.00 26.68 ? 113 LEU A CG 1 ATOM 583 C CD1 . LEU A 1 86 ? -48.763 -32.815 -8.134 1.00 26.39 ? 113 LEU A CD1 1 ATOM 584 C CD2 . LEU A 1 86 ? -49.872 -31.386 -6.379 1.00 26.73 ? 113 LEU A CD2 1 ATOM 585 N N . ALA A 1 87 ? -44.722 -30.228 -4.658 1.00 26.94 ? 114 ALA A N 1 ATOM 586 C CA . ALA A 1 87 ? -43.606 -30.485 -3.744 1.00 27.83 ? 114 ALA A CA 1 ATOM 587 C C . ALA A 1 87 ? -43.888 -30.021 -2.318 1.00 27.64 ? 114 ALA A C 1 ATOM 588 O O . ALA A 1 87 ? -44.653 -29.082 -2.101 1.00 27.40 ? 114 ALA A O 1 ATOM 589 C CB . ALA A 1 87 ? -42.341 -29.793 -4.254 1.00 28.99 ? 114 ALA A CB 1 ATOM 590 N N . PHE A 1 88 ? -43.236 -30.666 -1.352 1.00 26.70 ? 115 PHE A N 1 ATOM 591 C CA . PHE A 1 88 ? -43.318 -30.248 0.066 1.00 29.27 ? 115 PHE A CA 1 ATOM 592 C C . PHE A 1 88 ? -42.062 -30.580 0.894 1.00 30.23 ? 115 PHE A C 1 ATOM 593 O O . PHE A 1 88 ? -41.267 -31.477 0.545 1.00 31.34 ? 115 PHE A O 1 ATOM 594 C CB . PHE A 1 88 ? -44.509 -30.936 0.748 1.00 30.19 ? 115 PHE A CB 1 ATOM 595 C CG . PHE A 1 88 ? -44.528 -32.441 0.586 1.00 28.82 ? 115 PHE A CG 1 ATOM 596 C CD1 . PHE A 1 88 ? -44.948 -33.027 -0.611 1.00 28.02 ? 115 PHE A CD1 1 ATOM 597 C CD2 . PHE A 1 88 ? -44.182 -33.273 1.643 1.00 31.22 ? 115 PHE A CD2 1 ATOM 598 C CE1 . PHE A 1 88 ? -45.021 -34.405 -0.746 1.00 28.21 ? 115 PHE A CE1 1 ATOM 599 C CE2 . PHE A 1 88 ? -44.236 -34.676 1.504 1.00 30.12 ? 115 PHE A CE2 1 ATOM 600 C CZ . PHE A 1 88 ? -44.643 -35.235 0.314 1.00 28.66 ? 115 PHE A CZ 1 ATOM 601 N N . ALA A 1 89 ? -41.956 -29.929 2.041 1.00 29.87 ? 116 ALA A N 1 ATOM 602 C CA . ALA A 1 89 ? -40.740 -29.947 2.838 1.00 30.37 ? 116 ALA A CA 1 ATOM 603 C C . ALA A 1 89 ? -40.211 -31.331 3.181 1.00 31.94 ? 116 ALA A C 1 ATOM 604 O O . ALA A 1 89 ? -38.992 -31.541 3.173 1.00 33.71 ? 116 ALA A O 1 ATOM 605 C CB . ALA A 1 89 ? -40.951 -29.120 4.094 1.00 32.40 ? 116 ALA A CB 1 ATOM 606 N N . THR A 1 90 ? -41.110 -32.293 3.416 1.00 31.50 ? 117 THR A N 1 ATOM 607 C CA . THR A 1 90 ? -40.719 -33.619 3.896 1.00 32.67 ? 117 THR A CA 1 ATOM 608 C C . THR A 1 90 ? -40.876 -34.723 2.855 1.00 34.03 ? 117 THR A C 1 ATOM 609 O O . THR A 1 90 ? -41.027 -35.918 3.197 1.00 34.36 ? 117 THR A O 1 ATOM 610 C CB . THR A 1 90 ? -41.546 -33.983 5.157 1.00 35.66 ? 117 THR A CB 1 ATOM 611 O OG1 . THR A 1 90 ? -42.940 -33.774 4.888 1.00 37.00 ? 117 THR A OG1 1 ATOM 612 C CG2 . THR A 1 90 ? -41.144 -33.071 6.366 1.00 35.09 ? 117 THR A CG2 1 ATOM 613 N N . MET A 1 91 ? -40.822 -34.338 1.587 1.00 30.74 ? 118 MET A N 1 ATOM 614 C CA . MET A 1 91 ? -41.043 -35.288 0.483 1.00 30.16 ? 118 MET A CA 1 ATOM 615 C C . MET A 1 91 ? -39.949 -36.315 0.317 1.00 30.91 ? 118 MET A C 1 ATOM 616 O O . MET A 1 91 ? -40.172 -37.346 -0.340 1.00 31.69 ? 118 MET A O 1 ATOM 617 C CB . MET A 1 91 ? -41.271 -34.536 -0.855 1.00 29.79 ? 118 MET A CB 1 ATOM 618 C CG . MET A 1 91 ? -40.068 -33.751 -1.392 1.00 28.34 ? 118 MET A CG 1 ATOM 619 S SD . MET A 1 91 ? -40.519 -32.656 -2.762 1.00 28.48 ? 118 MET A SD 1 ATOM 620 C CE . MET A 1 91 ? -40.628 -33.854 -4.091 1.00 25.58 ? 118 MET A CE 1 ATOM 621 N N . PHE A 1 92 ? -38.762 -36.046 0.864 1.00 31.97 ? 119 PHE A N 1 ATOM 622 C CA . PHE A 1 92 ? -37.609 -36.987 0.752 1.00 35.33 ? 119 PHE A CA 1 ATOM 623 C C . PHE A 1 92 ? -37.183 -37.478 2.146 1.00 38.59 ? 119 PHE A C 1 ATOM 624 O O . PHE A 1 92 ? -37.158 -36.691 3.103 1.00 38.11 ? 119 PHE A O 1 ATOM 625 C CB . PHE A 1 92 ? -36.373 -36.319 0.112 1.00 34.35 ? 119 PHE A CB 1 ATOM 626 C CG . PHE A 1 92 ? -36.589 -35.797 -1.289 1.00 34.89 ? 119 PHE A CG 1 ATOM 627 C CD1 . PHE A 1 92 ? -37.007 -36.643 -2.319 1.00 35.27 ? 119 PHE A CD1 1 ATOM 628 C CD2 . PHE A 1 92 ? -36.316 -34.469 -1.594 1.00 34.79 ? 119 PHE A CD2 1 ATOM 629 C CE1 . PHE A 1 92 ? -37.187 -36.159 -3.619 1.00 35.07 ? 119 PHE A CE1 1 ATOM 630 C CE2 . PHE A 1 92 ? -36.503 -33.979 -2.884 1.00 36.26 ? 119 PHE A CE2 1 ATOM 631 C CZ . PHE A 1 92 ? -36.933 -34.829 -3.898 1.00 34.50 ? 119 PHE A CZ 1 ATOM 632 N N . ASN A 1 93 ? -36.820 -38.750 2.256 1.00 42.78 ? 120 ASN A N 1 ATOM 633 C CA . ASN A 1 93 ? -36.282 -39.296 3.520 1.00 50.31 ? 120 ASN A CA 1 ATOM 634 C C . ASN A 1 93 ? -34.923 -39.960 3.405 1.00 49.63 ? 120 ASN A C 1 ATOM 635 O O . ASN A 1 93 ? -34.411 -40.482 4.388 1.00 54.78 ? 120 ASN A O 1 ATOM 636 C CB . ASN A 1 93 ? -37.298 -40.243 4.195 1.00 52.83 ? 120 ASN A CB 1 ATOM 637 C CG . ASN A 1 93 ? -38.661 -39.598 4.304 1.00 54.50 ? 120 ASN A CG 1 ATOM 638 O OD1 . ASN A 1 93 ? -38.825 -38.584 5.001 1.00 51.36 ? 120 ASN A OD1 1 ATOM 639 N ND2 . ASN A 1 93 ? -39.640 -40.151 3.584 1.00 56.23 ? 120 ASN A ND2 1 ATOM 640 N N . SER A 1 94 ? -34.326 -39.916 2.226 1.00 49.46 ? 121 SER A N 1 ATOM 641 C CA . SER A 1 94 ? -32.937 -40.333 2.054 1.00 49.76 ? 121 SER A CA 1 ATOM 642 C C . SER A 1 94 ? -32.354 -39.539 0.894 1.00 51.11 ? 121 SER A C 1 ATOM 643 O O . SER A 1 94 ? -33.107 -39.056 0.037 1.00 46.87 ? 121 SER A O 1 ATOM 644 C CB . SER A 1 94 ? -32.844 -41.847 1.782 1.00 47.58 ? 121 SER A CB 1 ATOM 645 O OG . SER A 1 94 ? -33.408 -42.192 0.524 1.00 46.85 ? 121 SER A OG 1 ATOM 646 N N . SER A 1 95 ? -31.025 -39.402 0.882 1.00 49.13 ? 122 SER A N 1 ATOM 647 C CA . SER A 1 95 ? -30.296 -38.790 -0.228 1.00 49.34 ? 122 SER A CA 1 ATOM 648 C C . SER A 1 95 ? -30.564 -39.472 -1.568 1.00 49.93 ? 122 SER A C 1 ATOM 649 O O . SER A 1 95 ? -30.628 -38.805 -2.593 1.00 54.95 ? 122 SER A O 1 ATOM 650 C CB . SER A 1 95 ? -28.788 -38.778 0.065 1.00 50.65 ? 122 SER A CB 1 ATOM 651 O OG . SER A 1 95 ? -28.504 -37.842 1.093 1.00 51.61 ? 122 SER A OG 1 ATOM 652 N N . GLU A 1 96 ? -30.740 -40.790 -1.561 1.00 49.94 ? 123 GLU A N 1 ATOM 653 C CA A GLU A 1 96 ? -31.019 -41.515 -2.802 0.50 50.55 ? 123 GLU A CA 1 ATOM 654 C CA B GLU A 1 96 ? -31.035 -41.539 -2.776 0.50 50.48 ? 123 GLU A CA 1 ATOM 655 C C . GLU A 1 96 ? -32.363 -41.066 -3.395 1.00 49.08 ? 123 GLU A C 1 ATOM 656 O O . GLU A 1 96 ? -32.488 -40.940 -4.612 1.00 47.27 ? 123 GLU A O 1 ATOM 657 C CB A GLU A 1 96 ? -30.995 -43.036 -2.592 0.50 52.59 ? 123 GLU A CB 1 ATOM 658 C CB B GLU A 1 96 ? -31.084 -43.048 -2.481 0.50 52.50 ? 123 GLU A CB 1 ATOM 659 C CG A GLU A 1 96 ? -31.025 -43.861 -3.880 0.50 54.62 ? 123 GLU A CG 1 ATOM 660 C CG B GLU A 1 96 ? -29.840 -43.613 -1.793 0.50 54.60 ? 123 GLU A CG 1 ATOM 661 C CD A GLU A 1 96 ? -29.643 -44.188 -4.423 0.50 57.55 ? 123 GLU A CD 1 ATOM 662 C CD B GLU A 1 96 ? -29.913 -43.550 -0.270 0.50 55.91 ? 123 GLU A CD 1 ATOM 663 O OE1 A GLU A 1 96 ? -28.716 -44.397 -3.606 0.50 57.49 ? 123 GLU A OE1 1 ATOM 664 O OE1 B GLU A 1 96 ? -30.794 -44.213 0.317 0.50 59.58 ? 123 GLU A OE1 1 ATOM 665 O OE2 A GLU A 1 96 ? -29.492 -44.258 -5.669 0.50 57.09 ? 123 GLU A OE2 1 ATOM 666 O OE2 B GLU A 1 96 ? -29.090 -42.839 0.343 0.50 52.71 ? 123 GLU A OE2 1 ATOM 667 N N . GLN A 1 97 ? -33.362 -40.810 -2.553 1.00 44.63 ? 124 GLN A N 1 ATOM 668 C CA . GLN A 1 97 ? -34.665 -40.322 -3.039 1.00 43.77 ? 124 GLN A CA 1 ATOM 669 C C . GLN A 1 97 ? -34.547 -38.945 -3.734 1.00 42.57 ? 124 GLN A C 1 ATOM 670 O O . GLN A 1 97 ? -35.235 -38.707 -4.739 1.00 39.68 ? 124 GLN A O 1 ATOM 671 C CB . GLN A 1 97 ? -35.710 -40.254 -1.906 1.00 44.18 ? 124 GLN A CB 1 ATOM 672 C CG . GLN A 1 97 ? -36.172 -41.614 -1.375 1.00 49.01 ? 124 GLN A CG 1 ATOM 673 C CD . GLN A 1 97 ? -36.940 -41.550 -0.042 1.00 50.25 ? 124 GLN A CD 1 ATOM 674 O OE1 . GLN A 1 97 ? -37.139 -40.479 0.537 1.00 47.69 ? 124 GLN A OE1 1 ATOM 675 N NE2 . GLN A 1 97 ? -37.392 -42.711 0.435 1.00 51.10 ? 124 GLN A NE2 1 ATOM 676 N N . SER A 1 98 ? -33.680 -38.060 -3.208 1.00 37.53 ? 125 SER A N 1 ATOM 677 C CA . SER A 1 98 ? -33.568 -36.684 -3.694 1.00 36.63 ? 125 SER A CA 1 ATOM 678 C C . SER A 1 98 ? -32.584 -36.540 -4.838 1.00 35.61 ? 125 SER A C 1 ATOM 679 O O . SER A 1 98 ? -32.458 -35.455 -5.388 1.00 37.94 ? 125 SER A O 1 ATOM 680 C CB . SER A 1 98 ? -33.198 -35.708 -2.555 1.00 36.39 ? 125 SER A CB 1 ATOM 681 O OG . SER A 1 98 ? -31.845 -35.797 -2.205 1.00 36.29 ? 125 SER A OG 1 ATOM 682 N N . GLN A 1 99 ? -31.879 -37.619 -5.166 1.00 34.81 ? 126 GLN A N 1 ATOM 683 C CA . GLN A 1 99 ? -30.818 -37.613 -6.170 1.00 35.58 ? 126 GLN A CA 1 ATOM 684 C C . GLN A 1 99 ? -31.081 -38.446 -7.414 1.00 36.21 ? 126 GLN A C 1 ATOM 685 O O . GLN A 1 99 ? -30.406 -38.268 -8.422 1.00 36.18 ? 126 GLN A O 1 ATOM 686 C CB . GLN A 1 99 ? -29.512 -38.114 -5.547 1.00 36.31 ? 126 GLN A CB 1 ATOM 687 C CG . GLN A 1 99 ? -28.918 -37.056 -4.647 1.00 39.44 ? 126 GLN A CG 1 ATOM 688 C CD . GLN A 1 99 ? -27.679 -37.483 -3.901 1.00 38.87 ? 126 GLN A CD 1 ATOM 689 O OE1 . GLN A 1 99 ? -27.211 -38.594 -4.043 1.00 43.50 ? 126 GLN A OE1 1 ATOM 690 N NE2 . GLN A 1 99 ? -27.149 -36.580 -3.086 1.00 39.92 ? 126 GLN A NE2 1 ATOM 691 N N . LYS A 1 100 ? -32.043 -39.355 -7.342 1.00 37.45 ? 127 LYS A N 1 ATOM 692 C CA . LYS A 1 100 ? -32.298 -40.288 -8.426 1.00 40.93 ? 127 LYS A CA 1 ATOM 693 C C . LYS A 1 100 ? -33.791 -40.408 -8.683 1.00 36.34 ? 127 LYS A C 1 ATOM 694 O O . LYS A 1 100 ? -34.583 -40.450 -7.750 1.00 36.84 ? 127 LYS A O 1 ATOM 695 C CB . LYS A 1 100 ? -31.716 -41.651 -8.049 1.00 46.00 ? 127 LYS A CB 1 ATOM 696 C CG . LYS A 1 100 ? -31.351 -42.508 -9.230 1.00 52.38 ? 127 LYS A CG 1 ATOM 697 C CD . LYS A 1 100 ? -30.591 -43.731 -8.763 1.00 62.62 ? 127 LYS A CD 1 ATOM 698 C CE . LYS A 1 100 ? -30.029 -44.516 -9.939 1.00 68.11 ? 127 LYS A CE 1 ATOM 699 N NZ . LYS A 1 100 ? -29.126 -45.590 -9.432 1.00 71.86 ? 127 LYS A NZ 1 ATOM 700 N N . GLY A 1 101 ? -34.175 -40.460 -9.951 1.00 33.90 ? 128 GLY A N 1 ATOM 701 C CA . GLY A 1 101 ? -35.567 -40.701 -10.327 1.00 31.79 ? 128 GLY A CA 1 ATOM 702 C C . GLY A 1 101 ? -36.335 -39.395 -10.504 1.00 30.90 ? 128 GLY A C 1 ATOM 703 O O . GLY A 1 101 ? -35.779 -38.294 -10.313 1.00 28.07 ? 128 GLY A O 1 ATOM 704 N N . GLY A 1 102 ? -37.615 -39.512 -10.854 1.00 27.43 ? 129 GLY A N 1 ATOM 705 C CA . GLY A 1 102 ? -38.385 -38.339 -11.284 1.00 27.78 ? 129 GLY A CA 1 ATOM 706 C C . GLY A 1 102 ? -38.679 -37.361 -10.163 1.00 27.32 ? 129 GLY A C 1 ATOM 707 O O . GLY A 1 102 ? -38.893 -36.164 -10.382 1.00 25.68 ? 129 GLY A O 1 ATOM 708 N N . LEU A 1 103 ? -38.736 -37.883 -8.953 1.00 27.08 ? 130 LEU A N 1 ATOM 709 C CA . LEU A 1 103 ? -39.048 -37.066 -7.811 1.00 28.41 ? 130 LEU A CA 1 ATOM 710 C C . LEU A 1 103 ? -37.925 -36.075 -7.512 1.00 27.31 ? 130 LEU A C 1 ATOM 711 O O . LEU A 1 103 ? -38.196 -35.023 -6.917 1.00 26.71 ? 130 LEU A O 1 ATOM 712 C CB . LEU A 1 103 ? -39.349 -37.954 -6.613 1.00 30.15 ? 130 LEU A CB 1 ATOM 713 C CG . LEU A 1 103 ? -40.141 -37.304 -5.481 1.00 32.53 ? 130 LEU A CG 1 ATOM 714 C CD1 . LEU A 1 103 ? -41.574 -36.941 -5.901 1.00 31.84 ? 130 LEU A CD1 1 ATOM 715 C CD2 . LEU A 1 103 ? -40.144 -38.279 -4.300 1.00 31.76 ? 130 LEU A CD2 1 ATOM 716 N N . SER A 1 104 ? -36.705 -36.376 -7.989 1.00 25.32 ? 131 SER A N 1 ATOM 717 C CA . SER A 1 104 ? -35.550 -35.488 -7.826 1.00 24.70 ? 131 SER A CA 1 ATOM 718 C C . SER A 1 104 ? -35.549 -34.310 -8.819 1.00 24.74 ? 131 SER A C 1 ATOM 719 O O . SER A 1 104 ? -34.771 -33.341 -8.693 1.00 22.19 ? 131 SER A O 1 ATOM 720 C CB . SER A 1 104 ? -34.250 -36.302 -7.922 1.00 25.37 ? 131 SER A CB 1 ATOM 721 O OG . SER A 1 104 ? -33.873 -36.674 -9.263 1.00 25.53 ? 131 SER A OG 1 ATOM 722 N N . VAL A 1 105 ? -36.455 -34.376 -9.783 1.00 23.92 ? 132 VAL A N 1 ATOM 723 C CA . VAL A 1 105 ? -36.517 -33.404 -10.881 1.00 24.07 ? 132 VAL A CA 1 ATOM 724 C C . VAL A 1 105 ? -37.269 -32.126 -10.488 1.00 23.27 ? 132 VAL A C 1 ATOM 725 O O . VAL A 1 105 ? -38.395 -32.195 -10.026 1.00 24.65 ? 132 VAL A O 1 ATOM 726 C CB . VAL A 1 105 ? -37.215 -34.046 -12.120 1.00 22.97 ? 132 VAL A CB 1 ATOM 727 C CG1 . VAL A 1 105 ? -37.233 -33.067 -13.281 1.00 23.20 ? 132 VAL A CG1 1 ATOM 728 C CG2 . VAL A 1 105 ? -36.519 -35.352 -12.531 1.00 22.24 ? 132 VAL A CG2 1 ATOM 729 N N . ALA A 1 106 ? -36.646 -30.969 -10.691 1.00 21.56 ? 133 ALA A N 1 ATOM 730 C CA . ALA A 1 106 ? -37.307 -29.694 -10.527 1.00 22.72 ? 133 ALA A CA 1 ATOM 731 C C . ALA A 1 106 ? -37.671 -29.190 -11.909 1.00 23.19 ? 133 ALA A C 1 ATOM 732 O O . ALA A 1 106 ? -37.147 -29.667 -12.906 1.00 24.02 ? 133 ALA A O 1 ATOM 733 C CB . ALA A 1 106 ? -36.404 -28.683 -9.820 1.00 22.69 ? 133 ALA A CB 1 ATOM 734 N N . VAL A 1 107 ? -38.560 -28.208 -11.962 1.00 22.28 ? 134 VAL A N 1 ATOM 735 C CA . VAL A 1 107 ? -39.077 -27.689 -13.250 1.00 23.46 ? 134 VAL A CA 1 ATOM 736 C C . VAL A 1 107 ? -37.957 -26.991 -14.029 1.00 23.76 ? 134 VAL A C 1 ATOM 737 O O . VAL A 1 107 ? -37.382 -26.028 -13.538 1.00 23.66 ? 134 VAL A O 1 ATOM 738 C CB . VAL A 1 107 ? -40.247 -26.694 -13.029 1.00 23.31 ? 134 VAL A CB 1 ATOM 739 C CG1 . VAL A 1 107 ? -40.879 -26.291 -14.350 1.00 24.22 ? 134 VAL A CG1 1 ATOM 740 C CG2 . VAL A 1 107 ? -41.304 -27.325 -12.127 1.00 22.07 ? 134 VAL A CG2 1 ATOM 741 N N . PRO A 1 108 ? -37.611 -27.500 -15.235 1.00 23.47 ? 135 PRO A N 1 ATOM 742 C CA . PRO A 1 108 ? -36.479 -26.894 -15.964 1.00 23.78 ? 135 PRO A CA 1 ATOM 743 C C . PRO A 1 108 ? -36.746 -25.488 -16.441 1.00 24.46 ? 135 PRO A C 1 ATOM 744 O O . PRO A 1 108 ? -37.824 -25.206 -16.910 1.00 28.09 ? 135 PRO A O 1 ATOM 745 C CB . PRO A 1 108 ? -36.284 -27.826 -17.165 1.00 24.18 ? 135 PRO A CB 1 ATOM 746 C CG . PRO A 1 108 ? -36.921 -29.112 -16.756 1.00 24.18 ? 135 PRO A CG 1 ATOM 747 C CD . PRO A 1 108 ? -38.073 -28.739 -15.869 1.00 22.67 ? 135 PRO A CD 1 ATOM 748 N N . GLY A 1 109 ? -35.760 -24.610 -16.327 1.00 24.17 ? 136 GLY A N 1 ATOM 749 C CA . GLY A 1 109 ? -35.914 -23.239 -16.729 1.00 22.53 ? 136 GLY A CA 1 ATOM 750 C C . GLY A 1 109 ? -35.065 -22.891 -17.923 1.00 22.44 ? 136 GLY A C 1 ATOM 751 O O . GLY A 1 109 ? -35.172 -21.773 -18.451 1.00 20.68 ? 136 GLY A O 1 ATOM 752 N N . GLU A 1 110 ? -34.221 -23.823 -18.365 1.00 21.75 ? 137 GLU A N 1 ATOM 753 C CA . GLU A 1 110 ? -33.167 -23.464 -19.312 1.00 22.37 ? 137 GLU A CA 1 ATOM 754 C C . GLU A 1 110 ? -33.706 -22.680 -20.513 1.00 22.03 ? 137 GLU A C 1 ATOM 755 O O . GLU A 1 110 ? -33.178 -21.631 -20.883 1.00 19.57 ? 137 GLU A O 1 ATOM 756 C CB . GLU A 1 110 ? -32.419 -24.716 -19.812 1.00 23.31 ? 137 GLU A CB 1 ATOM 757 C CG . GLU A 1 110 ? -31.082 -24.405 -20.488 1.00 25.81 ? 137 GLU A CG 1 ATOM 758 C CD . GLU A 1 110 ? -29.908 -24.255 -19.505 1.00 28.58 ? 137 GLU A CD 1 ATOM 759 O OE1 . GLU A 1 110 ? -30.118 -24.496 -18.284 1.00 28.32 ? 137 GLU A OE1 1 ATOM 760 O OE2 . GLU A 1 110 ? -28.771 -23.918 -19.963 1.00 29.63 ? 137 GLU A OE2 1 ATOM 761 N N . ILE A 1 111 ? -34.724 -23.240 -21.158 1.00 23.96 ? 138 ILE A N 1 ATOM 762 C CA . ILE A 1 111 ? -35.225 -22.695 -22.412 1.00 22.94 ? 138 ILE A CA 1 ATOM 763 C C . ILE A 1 111 ? -35.936 -21.358 -22.226 1.00 22.71 ? 138 ILE A C 1 ATOM 764 O O . ILE A 1 111 ? -35.778 -20.460 -23.056 1.00 22.01 ? 138 ILE A O 1 ATOM 765 C CB . ILE A 1 111 ? -36.101 -23.733 -23.155 1.00 24.86 ? 138 ILE A CB 1 ATOM 766 C CG1 . ILE A 1 111 ? -35.219 -24.828 -23.781 1.00 26.06 ? 138 ILE A CG1 1 ATOM 767 C CG2 . ILE A 1 111 ? -36.929 -23.077 -24.262 1.00 25.03 ? 138 ILE A CG2 1 ATOM 768 C CD1 . ILE A 1 111 ? -34.369 -24.350 -24.968 1.00 26.82 ? 138 ILE A CD1 1 ATOM 769 N N . ARG A 1 112 ? -36.697 -21.190 -21.146 1.00 24.22 ? 139 ARG A N 1 ATOM 770 C CA . ARG A 1 112 ? -37.278 -19.863 -20.878 1.00 24.19 ? 139 ARG A CA 1 ATOM 771 C C . ARG A 1 112 ? -36.197 -18.811 -20.632 1.00 24.17 ? 139 ARG A C 1 ATOM 772 O O . ARG A 1 112 ? -36.359 -17.644 -21.001 1.00 24.58 ? 139 ARG A O 1 ATOM 773 C CB . ARG A 1 112 ? -38.179 -19.876 -19.662 1.00 26.26 ? 139 ARG A CB 1 ATOM 774 C CG . ARG A 1 112 ? -39.588 -20.395 -19.858 1.00 28.94 ? 139 ARG A CG 1 ATOM 775 C CD . ARG A 1 112 ? -40.365 -19.768 -20.988 1.00 29.75 ? 139 ARG A CD 1 ATOM 776 N NE . ARG A 1 112 ? -41.770 -20.155 -20.886 1.00 33.32 ? 139 ARG A NE 1 ATOM 777 C CZ . ARG A 1 112 ? -42.668 -19.995 -21.852 1.00 36.55 ? 139 ARG A CZ 1 ATOM 778 N NH1 . ARG A 1 112 ? -42.300 -19.453 -23.021 1.00 37.82 ? 139 ARG A NH1 1 ATOM 779 N NH2 . ARG A 1 112 ? -43.933 -20.380 -21.653 1.00 35.18 ? 139 ARG A NH2 1 ATOM 780 N N . GLY A 1 113 ? -35.111 -19.215 -19.978 1.00 23.01 ? 140 GLY A N 1 ATOM 781 C CA . GLY A 1 113 ? -33.970 -18.342 -19.802 1.00 24.04 ? 140 GLY A CA 1 ATOM 782 C C . GLY A 1 113 ? -33.335 -17.937 -21.122 1.00 24.95 ? 140 GLY A C 1 ATOM 783 O O . GLY A 1 113 ? -33.053 -16.763 -21.318 1.00 24.16 ? 140 GLY A O 1 ATOM 784 N N . TYR A 1 114 ? -33.108 -18.894 -22.032 1.00 24.67 ? 141 TYR A N 1 ATOM 785 C CA . TYR A 1 114 ? -32.553 -18.545 -23.352 1.00 25.72 ? 141 TYR A CA 1 ATOM 786 C C . TYR A 1 114 ? -33.511 -17.581 -24.087 1.00 25.66 ? 141 TYR A C 1 ATOM 787 O O . TYR A 1 114 ? -33.088 -16.617 -24.706 1.00 24.09 ? 141 TYR A O 1 ATOM 788 C CB . TYR A 1 114 ? -32.306 -19.775 -24.262 1.00 25.78 ? 141 TYR A CB 1 ATOM 789 C CG . TYR A 1 114 ? -31.347 -20.850 -23.788 1.00 25.15 ? 141 TYR A CG 1 ATOM 790 C CD1 . TYR A 1 114 ? -30.472 -20.638 -22.755 1.00 25.16 ? 141 TYR A CD1 1 ATOM 791 C CD2 . TYR A 1 114 ? -31.283 -22.076 -24.449 1.00 26.24 ? 141 TYR A CD2 1 ATOM 792 C CE1 . TYR A 1 114 ? -29.603 -21.620 -22.335 1.00 24.97 ? 141 TYR A CE1 1 ATOM 793 C CE2 . TYR A 1 114 ? -30.395 -23.064 -24.060 1.00 26.48 ? 141 TYR A CE2 1 ATOM 794 C CZ . TYR A 1 114 ? -29.567 -22.834 -22.984 1.00 26.56 ? 141 TYR A CZ 1 ATOM 795 O OH . TYR A 1 114 ? -28.722 -23.820 -22.530 1.00 26.11 ? 141 TYR A OH 1 ATOM 796 N N . GLU A 1 115 ? -34.808 -17.859 -24.012 1.00 26.77 ? 142 GLU A N 1 ATOM 797 C CA . GLU A 1 115 ? -35.807 -17.022 -24.678 1.00 28.56 ? 142 GLU A CA 1 ATOM 798 C C . GLU A 1 115 ? -35.810 -15.591 -24.144 1.00 28.01 ? 142 GLU A C 1 ATOM 799 O O . GLU A 1 115 ? -35.811 -14.654 -24.907 1.00 28.77 ? 142 GLU A O 1 ATOM 800 C CB . GLU A 1 115 ? -37.204 -17.617 -24.505 1.00 30.13 ? 142 GLU A CB 1 ATOM 801 C CG . GLU A 1 115 ? -38.303 -16.766 -25.110 1.00 30.95 ? 142 GLU A CG 1 ATOM 802 C CD . GLU A 1 115 ? -39.683 -17.312 -24.822 1.00 34.66 ? 142 GLU A CD 1 ATOM 803 O OE1 . GLU A 1 115 ? -39.975 -17.686 -23.649 1.00 38.54 ? 142 GLU A OE1 1 ATOM 804 O OE2 . GLU A 1 115 ? -40.486 -17.368 -25.779 1.00 37.17 ? 142 GLU A OE2 1 ATOM 805 N N . LEU A 1 116 ? -35.836 -15.420 -22.835 1.00 27.39 ? 143 LEU A N 1 ATOM 806 C CA . LEU A 1 116 ? -35.844 -14.074 -22.273 1.00 26.43 ? 143 LEU A CA 1 ATOM 807 C C . LEU A 1 116 ? -34.581 -13.319 -22.659 1.00 27.05 ? 143 LEU A C 1 ATOM 808 O O . LEU A 1 116 ? -34.647 -12.156 -23.064 1.00 27.64 ? 143 LEU A O 1 ATOM 809 C CB . LEU A 1 116 ? -35.988 -14.117 -20.751 1.00 26.33 ? 143 LEU A CB 1 ATOM 810 C CG . LEU A 1 116 ? -36.066 -12.773 -20.014 1.00 27.49 ? 143 LEU A CG 1 ATOM 811 C CD1 . LEU A 1 116 ? -37.156 -11.862 -20.555 1.00 28.38 ? 143 LEU A CD1 1 ATOM 812 C CD2 . LEU A 1 116 ? -36.296 -12.991 -18.529 1.00 29.06 ? 143 LEU A CD2 1 ATOM 813 N N . ALA A 1 117 ? -33.431 -13.973 -22.554 1.00 27.01 ? 144 ALA A N 1 ATOM 814 C CA . ALA A 1 117 ? -32.178 -13.310 -22.875 1.00 27.78 ? 144 ALA A CA 1 ATOM 815 C C . ALA A 1 117 ? -32.203 -12.901 -24.337 1.00 27.19 ? 144 ALA A C 1 ATOM 816 O O . ALA A 1 117 ? -31.755 -11.828 -24.705 1.00 26.42 ? 144 ALA A O 1 ATOM 817 C CB . ALA A 1 117 ? -30.986 -14.216 -22.583 1.00 26.46 ? 144 ALA A CB 1 ATOM 818 N N . HIS A 1 118 ? -32.724 -13.784 -25.169 1.00 28.95 ? 145 HIS A N 1 ATOM 819 C CA . HIS A 1 118 ? -32.724 -13.560 -26.590 1.00 30.71 ? 145 HIS A CA 1 ATOM 820 C C . HIS A 1 118 ? -33.701 -12.459 -26.998 1.00 32.25 ? 145 HIS A C 1 ATOM 821 O O . HIS A 1 118 ? -33.388 -11.661 -27.885 1.00 32.72 ? 145 HIS A O 1 ATOM 822 C CB . HIS A 1 118 ? -33.042 -14.845 -27.341 1.00 31.27 ? 145 HIS A CB 1 ATOM 823 C CG . HIS A 1 118 ? -32.874 -14.709 -28.814 1.00 33.89 ? 145 HIS A CG 1 ATOM 824 N ND1 . HIS A 1 118 ? -33.941 -14.621 -29.681 1.00 33.62 ? 145 HIS A ND1 1 ATOM 825 C CD2 . HIS A 1 118 ? -31.758 -14.594 -29.568 1.00 34.75 ? 145 HIS A CD2 1 ATOM 826 C CE1 . HIS A 1 118 ? -33.488 -14.489 -30.909 1.00 34.78 ? 145 HIS A CE1 1 ATOM 827 N NE2 . HIS A 1 118 ? -32.167 -14.459 -30.868 1.00 36.79 ? 145 HIS A NE2 1 ATOM 828 N N . GLN A 1 119 ? -34.874 -12.425 -26.367 1.00 34.17 ? 146 GLN A N 1 ATOM 829 C CA A GLN A 1 119 ? -35.819 -11.327 -26.559 0.50 36.38 ? 146 GLN A CA 1 ATOM 830 C CA B GLN A 1 119 ? -35.819 -11.327 -26.559 0.50 36.38 ? 146 GLN A CA 1 ATOM 831 C C . GLN A 1 119 ? -35.190 -9.986 -26.208 1.00 34.95 ? 146 GLN A C 1 ATOM 832 O O . GLN A 1 119 ? -35.469 -9.002 -26.841 1.00 33.88 ? 146 GLN A O 1 ATOM 833 C CB . GLN A 1 119 ? -37.055 -11.510 -25.685 1.00 39.19 ? 146 GLN A CB 1 ATOM 834 C CG . GLN A 1 119 ? -37.971 -12.634 -26.118 1.00 45.59 ? 146 GLN A CG 1 ATOM 835 C CD . GLN A 1 119 ? -39.085 -12.844 -25.110 1.00 52.93 ? 146 GLN A CD 1 ATOM 836 O OE1 . GLN A 1 119 ? -38.987 -12.419 -23.947 1.00 60.99 ? 146 GLN A OE1 1 ATOM 837 N NE2 . GLN A 1 119 ? -40.160 -13.486 -25.550 1.00 54.83 ? 146 GLN A NE2 1 ATOM 838 N N . ARG A 1 120 ? -34.351 -9.959 -25.177 1.00 35.46 ? 147 ARG A N 1 ATOM 839 C CA . ARG A 1 120 ? -33.786 -8.702 -24.708 1.00 35.26 ? 147 ARG A CA 1 ATOM 840 C C . ARG A 1 120 ? -32.555 -8.270 -25.478 1.00 34.41 ? 147 ARG A C 1 ATOM 841 O O . ARG A 1 120 ? -32.308 -7.088 -25.590 1.00 34.41 ? 147 ARG A O 1 ATOM 842 C CB . ARG A 1 120 ? -33.463 -8.765 -23.217 1.00 33.74 ? 147 ARG A CB 1 ATOM 843 C CG . ARG A 1 120 ? -34.712 -8.764 -22.334 1.00 36.06 ? 147 ARG A CG 1 ATOM 844 C CD . ARG A 1 120 ? -34.369 -8.761 -20.838 1.00 36.50 ? 147 ARG A CD 1 ATOM 845 N NE . ARG A 1 120 ? -33.540 -7.611 -20.474 1.00 37.24 ? 147 ARG A NE 1 ATOM 846 C CZ . ARG A 1 120 ? -33.999 -6.360 -20.340 1.00 40.07 ? 147 ARG A CZ 1 ATOM 847 N NH1 . ARG A 1 120 ? -35.283 -6.071 -20.533 1.00 37.13 ? 147 ARG A NH1 1 ATOM 848 N NH2 . ARG A 1 120 ? -33.163 -5.383 -20.011 1.00 42.09 ? 147 ARG A NH2 1 ATOM 849 N N . HIS A 1 121 ? -31.781 -9.228 -25.976 1.00 33.14 ? 148 HIS A N 1 ATOM 850 C CA . HIS A 1 121 ? -30.441 -8.951 -26.487 1.00 30.99 ? 148 HIS A CA 1 ATOM 851 C C . HIS A 1 121 ? -30.096 -9.674 -27.781 1.00 28.72 ? 148 HIS A C 1 ATOM 852 O O . HIS A 1 121 ? -28.983 -9.543 -28.252 1.00 30.97 ? 148 HIS A O 1 ATOM 853 C CB . HIS A 1 121 ? -29.411 -9.386 -25.443 1.00 31.95 ? 148 HIS A CB 1 ATOM 854 C CG . HIS A 1 121 ? -29.641 -8.809 -24.084 1.00 35.03 ? 148 HIS A CG 1 ATOM 855 N ND1 . HIS A 1 121 ? -29.321 -7.509 -23.765 1.00 36.91 ? 148 HIS A ND1 1 ATOM 856 C CD2 . HIS A 1 121 ? -30.166 -9.354 -22.960 1.00 36.02 ? 148 HIS A CD2 1 ATOM 857 C CE1 . HIS A 1 121 ? -29.647 -7.273 -22.509 1.00 35.81 ? 148 HIS A CE1 1 ATOM 858 N NE2 . HIS A 1 121 ? -30.152 -8.378 -21.994 1.00 35.80 ? 148 HIS A NE2 1 ATOM 859 N N . GLY A 1 122 ? -31.009 -10.466 -28.335 1.00 27.76 ? 149 GLY A N 1 ATOM 860 C CA . GLY A 1 122 ? -30.703 -11.241 -29.524 1.00 30.45 ? 149 GLY A CA 1 ATOM 861 C C . GLY A 1 122 ? -30.641 -10.372 -30.778 1.00 34.30 ? 149 GLY A C 1 ATOM 862 O O . GLY A 1 122 ? -31.370 -9.362 -30.886 1.00 34.82 ? 149 GLY A O 1 ATOM 863 N N . ARG A 1 123 ? -29.745 -10.737 -31.697 1.00 34.75 ? 150 ARG A N 1 ATOM 864 C CA A ARG A 1 123 ? -29.671 -10.092 -33.005 0.50 37.64 ? 150 ARG A CA 1 ATOM 865 C CA B ARG A 1 123 ? -29.652 -10.087 -33.002 0.50 36.57 ? 150 ARG A CA 1 ATOM 866 C C . ARG A 1 123 ? -29.886 -11.110 -34.121 1.00 37.77 ? 150 ARG A C 1 ATOM 867 O O . ARG A 1 123 ? -30.458 -10.778 -35.141 1.00 43.37 ? 150 ARG A O 1 ATOM 868 C CB A ARG A 1 123 ? -28.344 -9.341 -33.186 0.50 38.99 ? 150 ARG A CB 1 ATOM 869 C CB B ARG A 1 123 ? -28.307 -9.343 -33.159 0.50 36.64 ? 150 ARG A CB 1 ATOM 870 C CG A ARG A 1 123 ? -28.222 -8.072 -32.340 0.50 41.02 ? 150 ARG A CG 1 ATOM 871 C CG B ARG A 1 123 ? -28.026 -8.333 -32.036 0.50 36.99 ? 150 ARG A CG 1 ATOM 872 C CD A ARG A 1 123 ? -29.344 -7.080 -32.629 0.50 43.59 ? 150 ARG A CD 1 ATOM 873 C CD B ARG A 1 123 ? -27.131 -7.159 -32.441 0.50 37.94 ? 150 ARG A CD 1 ATOM 874 N NE A ARG A 1 123 ? -29.271 -5.882 -31.792 0.50 45.71 ? 150 ARG A NE 1 ATOM 875 N NE B ARG A 1 123 ? -25.707 -7.328 -32.115 0.50 38.88 ? 150 ARG A NE 1 ATOM 876 C CZ A ARG A 1 123 ? -29.847 -5.762 -30.598 0.50 47.71 ? 150 ARG A CZ 1 ATOM 877 C CZ B ARG A 1 123 ? -25.095 -6.793 -31.051 0.50 37.84 ? 150 ARG A CZ 1 ATOM 878 N NH1 A ARG A 1 123 ? -30.542 -6.764 -30.072 0.50 47.48 ? 150 ARG A NH1 1 ATOM 879 N NH1 B ARG A 1 123 ? -25.768 -6.056 -30.180 0.50 37.22 ? 150 ARG A NH1 1 ATOM 880 N NH2 A ARG A 1 123 ? -29.719 -4.636 -29.918 0.50 50.00 ? 150 ARG A NH2 1 ATOM 881 N NH2 B ARG A 1 123 ? -23.796 -6.990 -30.859 0.50 38.19 ? 150 ARG A NH2 1 ATOM 882 N N . LEU A 1 124 ? -29.463 -12.358 -33.910 1.00 34.92 ? 151 LEU A N 1 ATOM 883 C CA . LEU A 1 124 ? -29.676 -13.420 -34.868 1.00 33.56 ? 151 LEU A CA 1 ATOM 884 C C . LEU A 1 124 ? -31.012 -14.098 -34.633 1.00 33.62 ? 151 LEU A C 1 ATOM 885 O O . LEU A 1 124 ? -31.573 -14.025 -33.539 1.00 33.90 ? 151 LEU A O 1 ATOM 886 C CB . LEU A 1 124 ? -28.579 -14.469 -34.774 1.00 34.51 ? 151 LEU A CB 1 ATOM 887 C CG . LEU A 1 124 ? -27.166 -14.003 -35.048 1.00 37.47 ? 151 LEU A CG 1 ATOM 888 C CD1 . LEU A 1 124 ? -26.160 -15.082 -34.675 1.00 37.85 ? 151 LEU A CD1 1 ATOM 889 C CD2 . LEU A 1 124 ? -26.996 -13.591 -36.511 1.00 39.21 ? 151 LEU A CD2 1 ATOM 890 N N . PRO A 1 125 ? -31.546 -14.760 -35.671 1.00 33.49 ? 152 PRO A N 1 ATOM 891 C CA . PRO A 1 125 ? -32.800 -15.458 -35.476 1.00 33.32 ? 152 PRO A CA 1 ATOM 892 C C . PRO A 1 125 ? -32.634 -16.635 -34.514 1.00 34.27 ? 152 PRO A C 1 ATOM 893 O O . PRO A 1 125 ? -31.578 -17.294 -34.477 1.00 31.37 ? 152 PRO A O 1 ATOM 894 C CB . PRO A 1 125 ? -33.167 -15.957 -36.884 1.00 35.63 ? 152 PRO A CB 1 ATOM 895 C CG . PRO A 1 125 ? -32.349 -15.128 -37.826 1.00 36.09 ? 152 PRO A CG 1 ATOM 896 C CD . PRO A 1 125 ? -31.089 -14.810 -37.072 1.00 34.99 ? 152 PRO A CD 1 ATOM 897 N N . TRP A 1 126 ? -33.684 -16.875 -33.733 1.00 33.36 ? 153 TRP A N 1 ATOM 898 C CA . TRP A 1 126 ? -33.727 -17.997 -32.798 1.00 33.38 ? 153 TRP A CA 1 ATOM 899 C C . TRP A 1 126 ? -33.190 -19.291 -33.426 1.00 31.25 ? 153 TRP A C 1 ATOM 900 O O . TRP A 1 126 ? -32.277 -19.923 -32.885 1.00 31.53 ? 153 TRP A O 1 ATOM 901 C CB . TRP A 1 126 ? -35.163 -18.145 -32.301 1.00 32.84 ? 153 TRP A CB 1 ATOM 902 C CG . TRP A 1 126 ? -35.442 -19.232 -31.327 1.00 33.90 ? 153 TRP A CG 1 ATOM 903 C CD1 . TRP A 1 126 ? -36.124 -20.380 -31.579 1.00 33.68 ? 153 TRP A CD1 1 ATOM 904 C CD2 . TRP A 1 126 ? -35.135 -19.244 -29.924 1.00 32.30 ? 153 TRP A CD2 1 ATOM 905 N NE1 . TRP A 1 126 ? -36.233 -21.129 -30.435 1.00 34.27 ? 153 TRP A NE1 1 ATOM 906 C CE2 . TRP A 1 126 ? -35.647 -20.449 -29.399 1.00 32.42 ? 153 TRP A CE2 1 ATOM 907 C CE3 . TRP A 1 126 ? -34.481 -18.359 -29.066 1.00 31.73 ? 153 TRP A CE3 1 ATOM 908 C CZ2 . TRP A 1 126 ? -35.527 -20.795 -28.055 1.00 32.73 ? 153 TRP A CZ2 1 ATOM 909 C CZ3 . TRP A 1 126 ? -34.339 -18.709 -27.732 1.00 33.34 ? 153 TRP A CZ3 1 ATOM 910 C CH2 . TRP A 1 126 ? -34.877 -19.913 -27.229 1.00 32.88 ? 153 TRP A CH2 1 ATOM 911 N N . ALA A 1 127 ? -33.698 -19.643 -34.596 1.00 30.48 ? 154 ALA A N 1 ATOM 912 C CA . ALA A 1 127 ? -33.368 -20.941 -35.219 1.00 31.38 ? 154 ALA A CA 1 ATOM 913 C C . ALA A 1 127 ? -31.907 -21.096 -35.564 1.00 31.25 ? 154 ALA A C 1 ATOM 914 O O . ALA A 1 127 ? -31.354 -22.177 -35.452 1.00 34.15 ? 154 ALA A O 1 ATOM 915 C CB . ALA A 1 127 ? -34.211 -21.175 -36.459 1.00 31.42 ? 154 ALA A CB 1 ATOM 916 N N . ARG A 1 128 ? -31.285 -20.008 -35.985 1.00 31.04 ? 155 ARG A N 1 ATOM 917 C CA . ARG A 1 128 ? -29.876 -19.989 -36.279 1.00 30.50 ? 155 ARG A CA 1 ATOM 918 C C . ARG A 1 128 ? -29.007 -20.404 -35.075 1.00 31.71 ? 155 ARG A C 1 ATOM 919 O O . ARG A 1 128 ? -27.921 -20.958 -35.250 1.00 29.01 ? 155 ARG A O 1 ATOM 920 C CB . ARG A 1 128 ? -29.504 -18.587 -36.777 1.00 31.89 ? 155 ARG A CB 1 ATOM 921 C CG . ARG A 1 128 ? -28.025 -18.229 -36.761 1.00 32.16 ? 155 ARG A CG 1 ATOM 922 C CD . ARG A 1 128 ? -27.204 -19.056 -37.718 1.00 30.84 ? 155 ARG A CD 1 ATOM 923 N NE . ARG A 1 128 ? -25.793 -18.670 -37.630 1.00 29.08 ? 155 ARG A NE 1 ATOM 924 C CZ . ARG A 1 128 ? -24.917 -19.157 -36.750 1.00 30.54 ? 155 ARG A CZ 1 ATOM 925 N NH1 . ARG A 1 128 ? -25.286 -20.056 -35.838 1.00 30.33 ? 155 ARG A NH1 1 ATOM 926 N NH2 . ARG A 1 128 ? -23.652 -18.740 -36.768 1.00 31.06 ? 155 ARG A NH2 1 ATOM 927 N N . LEU A 1 129 ? -29.487 -20.157 -33.857 1.00 32.18 ? 156 LEU A N 1 ATOM 928 C CA . LEU A 1 129 ? -28.700 -20.482 -32.667 1.00 31.11 ? 156 LEU A CA 1 ATOM 929 C C . LEU A 1 129 ? -28.630 -21.988 -32.435 1.00 30.53 ? 156 LEU A C 1 ATOM 930 O O . LEU A 1 129 ? -27.680 -22.490 -31.831 1.00 28.91 ? 156 LEU A O 1 ATOM 931 C CB . LEU A 1 129 ? -29.291 -19.803 -31.442 1.00 30.69 ? 156 LEU A CB 1 ATOM 932 C CG . LEU A 1 129 ? -29.407 -18.281 -31.505 1.00 32.23 ? 156 LEU A CG 1 ATOM 933 C CD1 . LEU A 1 129 ? -30.025 -17.811 -30.204 1.00 32.51 ? 156 LEU A CD1 1 ATOM 934 C CD2 . LEU A 1 129 ? -28.080 -17.573 -31.752 1.00 33.00 ? 156 LEU A CD2 1 ATOM 935 N N . PHE A 1 130 ? -29.654 -22.701 -32.909 1.00 31.10 ? 157 PHE A N 1 ATOM 936 C CA . PHE A 1 130 ? -29.758 -24.140 -32.739 1.00 29.08 ? 157 PHE A CA 1 ATOM 937 C C . PHE A 1 130 ? -29.079 -24.905 -33.862 1.00 28.64 ? 157 PHE A C 1 ATOM 938 O O . PHE A 1 130 ? -28.686 -26.058 -33.679 1.00 27.10 ? 157 PHE A O 1 ATOM 939 C CB . PHE A 1 130 ? -31.223 -24.558 -32.731 1.00 30.38 ? 157 PHE A CB 1 ATOM 940 C CG . PHE A 1 130 ? -31.947 -24.202 -31.474 1.00 27.90 ? 157 PHE A CG 1 ATOM 941 C CD1 . PHE A 1 130 ? -32.430 -22.921 -31.284 1.00 27.36 ? 157 PHE A CD1 1 ATOM 942 C CD2 . PHE A 1 130 ? -32.142 -25.151 -30.478 1.00 27.50 ? 157 PHE A CD2 1 ATOM 943 C CE1 . PHE A 1 130 ? -33.092 -22.593 -30.117 1.00 26.67 ? 157 PHE A CE1 1 ATOM 944 C CE2 . PHE A 1 130 ? -32.793 -24.819 -29.297 1.00 27.36 ? 157 PHE A CE2 1 ATOM 945 C CZ . PHE A 1 130 ? -33.280 -23.542 -29.128 1.00 25.39 ? 157 PHE A CZ 1 ATOM 946 N N . GLN A 1 131 ? -28.960 -24.277 -35.023 1.00 29.68 ? 158 GLN A N 1 ATOM 947 C CA . GLN A 1 131 ? -28.567 -24.995 -36.259 1.00 31.52 ? 158 GLN A CA 1 ATOM 948 C C . GLN A 1 131 ? -27.301 -25.826 -36.103 1.00 27.76 ? 158 GLN A C 1 ATOM 949 O O . GLN A 1 131 ? -27.287 -26.989 -36.427 1.00 30.54 ? 158 GLN A O 1 ATOM 950 C CB . GLN A 1 131 ? -28.429 -24.023 -37.450 1.00 33.98 ? 158 GLN A CB 1 ATOM 951 C CG . GLN A 1 131 ? -28.436 -24.707 -38.812 1.00 40.65 ? 158 GLN A CG 1 ATOM 952 C CD . GLN A 1 131 ? -27.126 -25.397 -39.192 1.00 46.92 ? 158 GLN A CD 1 ATOM 953 O OE1 . GLN A 1 131 ? -27.131 -26.534 -39.744 1.00 50.66 ? 158 GLN A OE1 1 ATOM 954 N NE2 . GLN A 1 131 ? -25.986 -24.723 -38.905 1.00 47.40 ? 158 GLN A NE2 1 ATOM 955 N N . PRO A 1 132 ? -26.218 -25.228 -35.617 1.00 27.99 ? 159 PRO A N 1 ATOM 956 C CA . PRO A 1 132 ? -25.016 -26.040 -35.538 1.00 27.50 ? 159 PRO A CA 1 ATOM 957 C C . PRO A 1 132 ? -25.121 -27.197 -34.538 1.00 27.67 ? 159 PRO A C 1 ATOM 958 O O . PRO A 1 132 ? -24.436 -28.204 -34.712 1.00 27.40 ? 159 PRO A O 1 ATOM 959 C CB . PRO A 1 132 ? -23.943 -25.051 -35.091 1.00 28.64 ? 159 PRO A CB 1 ATOM 960 C CG . PRO A 1 132 ? -24.562 -23.688 -35.166 1.00 28.27 ? 159 PRO A CG 1 ATOM 961 C CD . PRO A 1 132 ? -26.028 -23.880 -35.075 1.00 27.86 ? 159 PRO A CD 1 ATOM 962 N N . SER A 1 133 ? -25.948 -27.068 -33.499 1.00 25.49 ? 160 SER A N 1 ATOM 963 C CA . SER A 1 133 ? -26.058 -28.161 -32.518 1.00 26.50 ? 160 SER A CA 1 ATOM 964 C C . SER A 1 133 ? -26.973 -29.293 -33.021 1.00 27.15 ? 160 SER A C 1 ATOM 965 O O . SER A 1 133 ? -26.727 -30.453 -32.743 1.00 29.31 ? 160 SER A O 1 ATOM 966 C CB . SER A 1 133 ? -26.500 -27.617 -31.165 1.00 26.04 ? 160 SER A CB 1 ATOM 967 O OG . SER A 1 133 ? -25.438 -26.897 -30.555 1.00 26.31 ? 160 SER A OG 1 ATOM 968 N N . ILE A 1 134 ? -27.994 -28.949 -33.799 1.00 26.44 ? 161 ILE A N 1 ATOM 969 C CA . ILE A 1 134 ? -28.803 -29.951 -34.481 1.00 27.67 ? 161 ILE A CA 1 ATOM 970 C C . ILE A 1 134 ? -27.907 -30.846 -35.331 1.00 28.80 ? 161 ILE A C 1 ATOM 971 O O . ILE A 1 134 ? -27.961 -32.058 -35.209 1.00 29.10 ? 161 ILE A O 1 ATOM 972 C CB . ILE A 1 134 ? -29.920 -29.306 -35.329 1.00 26.43 ? 161 ILE A CB 1 ATOM 973 C CG1 . ILE A 1 134 ? -30.963 -28.677 -34.413 1.00 24.54 ? 161 ILE A CG1 1 ATOM 974 C CG2 . ILE A 1 134 ? -30.634 -30.354 -36.189 1.00 27.55 ? 161 ILE A CG2 1 ATOM 975 C CD1 . ILE A 1 134 ? -31.785 -27.580 -35.065 1.00 23.69 ? 161 ILE A CD1 1 ATOM 976 N N . GLN A 1 135 ? -27.023 -30.241 -36.115 1.00 29.85 ? 162 GLN A N 1 ATOM 977 C CA . GLN A 1 135 ? -26.096 -31.018 -36.925 1.00 33.08 ? 162 GLN A CA 1 ATOM 978 C C . GLN A 1 135 ? -25.218 -31.950 -36.118 1.00 33.06 ? 162 GLN A C 1 ATOM 979 O O . GLN A 1 135 ? -25.055 -33.118 -36.465 1.00 32.69 ? 162 GLN A O 1 ATOM 980 C CB . GLN A 1 135 ? -25.158 -30.109 -37.696 1.00 35.73 ? 162 GLN A CB 1 ATOM 981 C CG . GLN A 1 135 ? -25.747 -29.440 -38.904 1.00 43.35 ? 162 GLN A CG 1 ATOM 982 C CD . GLN A 1 135 ? -24.657 -28.966 -39.868 1.00 53.75 ? 162 GLN A CD 1 ATOM 983 O OE1 . GLN A 1 135 ? -23.599 -29.595 -40.014 1.00 56.82 ? 162 GLN A OE1 1 ATOM 984 N NE2 . GLN A 1 135 ? -24.917 -27.862 -40.528 1.00 60.84 ? 162 GLN A NE2 1 ATOM 985 N N . LEU A 1 136 ? -24.602 -31.380 -35.087 1.00 31.22 ? 163 LEU A N 1 ATOM 986 C CA . LEU A 1 136 ? -23.710 -32.082 -34.209 1.00 32.22 ? 163 LEU A CA 1 ATOM 987 C C . LEU A 1 136 ? -24.386 -33.287 -33.594 1.00 31.36 ? 163 LEU A C 1 ATOM 988 O O . LEU A 1 136 ? -23.850 -34.383 -33.619 1.00 33.13 ? 163 LEU A O 1 ATOM 989 C CB . LEU A 1 136 ? -23.286 -31.130 -33.104 1.00 35.73 ? 163 LEU A CB 1 ATOM 990 C CG . LEU A 1 136 ? -21.888 -31.105 -32.533 1.00 42.35 ? 163 LEU A CG 1 ATOM 991 C CD1 . LEU A 1 136 ? -20.777 -31.176 -33.580 1.00 43.61 ? 163 LEU A CD1 1 ATOM 992 C CD2 . LEU A 1 136 ? -21.767 -29.812 -31.726 1.00 44.86 ? 163 LEU A CD2 1 ATOM 993 N N . ALA A 1 137 ? -25.564 -33.093 -33.026 1.00 30.15 ? 164 ALA A N 1 ATOM 994 C CA . ALA A 1 137 ? -26.256 -34.209 -32.367 1.00 31.67 ? 164 ALA A CA 1 ATOM 995 C C . ALA A 1 137 ? -26.609 -35.328 -33.367 1.00 33.10 ? 164 ALA A C 1 ATOM 996 O O . ALA A 1 137 ? -26.590 -36.503 -33.037 1.00 33.08 ? 164 ALA A O 1 ATOM 997 C CB . ALA A 1 137 ? -27.513 -33.718 -31.668 1.00 29.59 ? 164 ALA A CB 1 ATOM 998 N N . ARG A 1 138 ? -26.912 -34.945 -34.593 1.00 36.93 ? 165 ARG A N 1 ATOM 999 C CA . ARG A 1 138 ? -27.419 -35.885 -35.581 1.00 39.05 ? 165 ARG A CA 1 ATOM 1000 C C . ARG A 1 138 ? -26.279 -36.670 -36.226 1.00 39.43 ? 165 ARG A C 1 ATOM 1001 O O . ARG A 1 138 ? -26.405 -37.860 -36.470 1.00 42.00 ? 165 ARG A O 1 ATOM 1002 C CB . ARG A 1 138 ? -28.240 -35.130 -36.607 1.00 39.13 ? 165 ARG A CB 1 ATOM 1003 C CG . ARG A 1 138 ? -29.319 -35.964 -37.237 1.00 45.17 ? 165 ARG A CG 1 ATOM 1004 C CD . ARG A 1 138 ? -30.255 -35.057 -38.000 1.00 46.47 ? 165 ARG A CD 1 ATOM 1005 N NE . ARG A 1 138 ? -31.481 -34.762 -37.271 1.00 43.43 ? 165 ARG A NE 1 ATOM 1006 C CZ . ARG A 1 138 ? -32.248 -33.691 -37.495 1.00 42.54 ? 165 ARG A CZ 1 ATOM 1007 N NH1 . ARG A 1 138 ? -31.904 -32.790 -38.408 1.00 38.69 ? 165 ARG A NH1 1 ATOM 1008 N NH2 . ARG A 1 138 ? -33.368 -33.511 -36.788 1.00 41.82 ? 165 ARG A NH2 1 ATOM 1009 N N . GLN A 1 139 ? -25.152 -35.997 -36.422 1.00 42.49 ? 166 GLN A N 1 ATOM 1010 C CA . GLN A 1 139 ? -23.969 -36.543 -37.081 1.00 45.64 ? 166 GLN A CA 1 ATOM 1011 C C . GLN A 1 139 ? -23.109 -37.359 -36.122 1.00 46.98 ? 166 GLN A C 1 ATOM 1012 O O . GLN A 1 139 ? -22.543 -38.414 -36.499 1.00 43.63 ? 166 GLN A O 1 ATOM 1013 C CB . GLN A 1 139 ? -23.131 -35.380 -37.587 1.00 49.46 ? 166 GLN A CB 1 ATOM 1014 C CG . GLN A 1 139 ? -22.066 -35.744 -38.605 1.00 59.17 ? 166 GLN A CG 1 ATOM 1015 C CD . GLN A 1 139 ? -20.990 -34.684 -38.715 1.00 63.10 ? 166 GLN A CD 1 ATOM 1016 O OE1 . GLN A 1 139 ? -21.237 -33.480 -38.517 1.00 66.90 ? 166 GLN A OE1 1 ATOM 1017 N NE2 . GLN A 1 139 ? -19.781 -35.126 -39.018 1.00 68.32 ? 166 GLN A NE2 1 ATOM 1018 N N . GLY A 1 140 ? -22.979 -36.824 -34.901 1.00 40.01 ? 167 GLY A N 1 ATOM 1019 C CA . GLY A 1 140 ? -22.207 -37.435 -33.836 1.00 38.18 ? 167 GLY A CA 1 ATOM 1020 C C . GLY A 1 140 ? -20.939 -36.644 -33.622 1.00 37.48 ? 167 GLY A C 1 ATOM 1021 O O . GLY A 1 140 ? -20.604 -35.783 -34.432 1.00 39.17 ? 167 GLY A O 1 ATOM 1022 N N . PHE A 1 141 ? -20.218 -36.937 -32.546 1.00 33.48 ? 168 PHE A N 1 ATOM 1023 C CA . PHE A 1 141 ? -18.952 -36.250 -32.273 1.00 33.24 ? 168 PHE A CA 1 ATOM 1024 C C . PHE A 1 141 ? -18.133 -37.161 -31.360 1.00 32.12 ? 168 PHE A C 1 ATOM 1025 O O . PHE A 1 141 ? -18.699 -38.007 -30.667 1.00 32.24 ? 168 PHE A O 1 ATOM 1026 C CB . PHE A 1 141 ? -19.195 -34.850 -31.636 1.00 34.64 ? 168 PHE A CB 1 ATOM 1027 C CG . PHE A 1 141 ? -20.135 -34.887 -30.461 1.00 34.35 ? 168 PHE A CG 1 ATOM 1028 C CD1 . PHE A 1 141 ? -19.681 -35.271 -29.208 1.00 35.32 ? 168 PHE A CD1 1 ATOM 1029 C CD2 . PHE A 1 141 ? -21.480 -34.629 -30.628 1.00 34.22 ? 168 PHE A CD2 1 ATOM 1030 C CE1 . PHE A 1 141 ? -20.553 -35.344 -28.125 1.00 38.70 ? 168 PHE A CE1 1 ATOM 1031 C CE2 . PHE A 1 141 ? -22.358 -34.706 -29.558 1.00 36.42 ? 168 PHE A CE2 1 ATOM 1032 C CZ . PHE A 1 141 ? -21.897 -35.060 -28.299 1.00 36.36 ? 168 PHE A CZ 1 ATOM 1033 N N . PRO A 1 142 ? -16.800 -37.033 -31.392 1.00 32.94 ? 169 PRO A N 1 ATOM 1034 C CA . PRO A 1 142 ? -15.996 -37.827 -30.479 1.00 34.76 ? 169 PRO A CA 1 ATOM 1035 C C . PRO A 1 142 ? -16.192 -37.384 -29.033 1.00 36.16 ? 169 PRO A C 1 ATOM 1036 O O . PRO A 1 142 ? -16.296 -36.201 -28.759 1.00 37.45 ? 169 PRO A O 1 ATOM 1037 C CB . PRO A 1 142 ? -14.559 -37.563 -30.940 1.00 36.12 ? 169 PRO A CB 1 ATOM 1038 C CG . PRO A 1 142 ? -14.616 -36.303 -31.719 1.00 37.01 ? 169 PRO A CG 1 ATOM 1039 C CD . PRO A 1 142 ? -15.977 -36.284 -32.356 1.00 35.80 ? 169 PRO A CD 1 ATOM 1040 N N . VAL A 1 143 ? -16.262 -38.350 -28.130 1.00 36.56 ? 170 VAL A N 1 ATOM 1041 C CA . VAL A 1 143 ? -16.469 -38.089 -26.727 1.00 35.59 ? 170 VAL A CA 1 ATOM 1042 C C . VAL A 1 143 ? -15.216 -37.402 -26.153 1.00 37.36 ? 170 VAL A C 1 ATOM 1043 O O . VAL A 1 143 ? -14.111 -37.902 -26.324 1.00 41.24 ? 170 VAL A O 1 ATOM 1044 C CB . VAL A 1 143 ? -16.765 -39.408 -25.989 1.00 35.05 ? 170 VAL A CB 1 ATOM 1045 C CG1 . VAL A 1 143 ? -16.595 -39.262 -24.485 1.00 35.99 ? 170 VAL A CG1 1 ATOM 1046 C CG2 . VAL A 1 143 ? -18.168 -39.892 -26.309 1.00 35.19 ? 170 VAL A CG2 1 ATOM 1047 N N . GLY A 1 144 ? -15.395 -36.262 -25.488 1.00 35.60 ? 171 GLY A N 1 ATOM 1048 C CA . GLY A 1 144 ? -14.287 -35.484 -24.903 1.00 33.68 ? 171 GLY A CA 1 ATOM 1049 C C . GLY A 1 144 ? -13.807 -36.041 -23.576 1.00 35.27 ? 171 GLY A C 1 ATOM 1050 O O . GLY A 1 144 ? -14.434 -36.907 -22.980 1.00 36.92 ? 171 GLY A O 1 ATOM 1051 N N . LYS A 1 145 ? -12.680 -35.531 -23.103 1.00 37.40 ? 172 LYS A N 1 ATOM 1052 C CA . LYS A 1 145 ? -12.102 -35.952 -21.821 1.00 38.69 ? 172 LYS A CA 1 ATOM 1053 C C . LYS A 1 145 ? -13.103 -35.851 -20.664 1.00 35.73 ? 172 LYS A C 1 ATOM 1054 O O . LYS A 1 145 ? -13.295 -36.808 -19.898 1.00 32.86 ? 172 LYS A O 1 ATOM 1055 C CB . LYS A 1 145 ? -10.901 -35.065 -21.542 1.00 41.44 ? 172 LYS A CB 1 ATOM 1056 C CG . LYS A 1 145 ? -10.110 -35.355 -20.286 1.00 46.20 ? 172 LYS A CG 1 ATOM 1057 C CD . LYS A 1 145 ? -9.403 -34.068 -19.875 1.00 50.51 ? 172 LYS A CD 1 ATOM 1058 C CE . LYS A 1 145 ? -8.064 -34.298 -19.229 1.00 55.07 ? 172 LYS A CE 1 ATOM 1059 N NZ . LYS A 1 145 ? -7.311 -33.008 -19.236 1.00 60.35 ? 172 LYS A NZ 1 ATOM 1060 N N . GLY A 1 146 ? -13.762 -34.696 -20.571 1.00 33.82 ? 173 GLY A N 1 ATOM 1061 C CA . GLY A 1 146 ? -14.656 -34.404 -19.457 1.00 31.98 ? 173 GLY A CA 1 ATOM 1062 C C . GLY A 1 146 ? -15.814 -35.359 -19.375 1.00 29.22 ? 173 GLY A C 1 ATOM 1063 O O . GLY A 1 146 ? -16.098 -35.908 -18.349 1.00 29.81 ? 173 GLY A O 1 ATOM 1064 N N . LEU A 1 147 ? -16.474 -35.582 -20.490 1.00 33.43 ? 174 LEU A N 1 ATOM 1065 C CA . LEU A 1 147 ? -17.577 -36.527 -20.526 1.00 32.23 ? 174 LEU A CA 1 ATOM 1066 C C . LEU A 1 147 ? -17.089 -37.934 -20.275 1.00 32.13 ? 174 LEU A C 1 ATOM 1067 O O . LEU A 1 147 ? -17.761 -38.705 -19.598 1.00 32.04 ? 174 LEU A O 1 ATOM 1068 C CB . LEU A 1 147 ? -18.280 -36.435 -21.870 1.00 33.06 ? 174 LEU A CB 1 ATOM 1069 C CG . LEU A 1 147 ? -19.427 -37.406 -22.134 1.00 35.06 ? 174 LEU A CG 1 ATOM 1070 C CD1 . LEU A 1 147 ? -20.515 -37.379 -21.069 1.00 35.90 ? 174 LEU A CD1 1 ATOM 1071 C CD2 . LEU A 1 147 ? -20.004 -37.081 -23.506 1.00 36.60 ? 174 LEU A CD2 1 ATOM 1072 N N . ALA A 1 148 ? -15.926 -38.284 -20.827 1.00 32.69 ? 175 ALA A N 1 ATOM 1073 C CA . ALA A 1 148 ? -15.391 -39.644 -20.647 1.00 33.00 ? 175 ALA A CA 1 ATOM 1074 C C . ALA A 1 148 ? -15.171 -39.950 -19.171 1.00 31.77 ? 175 ALA A C 1 ATOM 1075 O O . ALA A 1 148 ? -15.544 -41.019 -18.696 1.00 30.38 ? 175 ALA A O 1 ATOM 1076 C CB . ALA A 1 148 ? -14.082 -39.828 -21.430 1.00 34.07 ? 175 ALA A CB 1 ATOM 1077 N N . ALA A 1 149 ? -14.576 -39.009 -18.444 1.00 31.11 ? 176 ALA A N 1 ATOM 1078 C CA . ALA A 1 149 ? -14.372 -39.213 -17.016 1.00 33.80 ? 176 ALA A CA 1 ATOM 1079 C C . ALA A 1 149 ? -15.706 -39.275 -16.288 1.00 34.80 ? 176 ALA A C 1 ATOM 1080 O O . ALA A 1 149 ? -15.867 -40.074 -15.350 1.00 36.67 ? 176 ALA A O 1 ATOM 1081 C CB . ALA A 1 149 ? -13.486 -38.121 -16.401 1.00 33.65 ? 176 ALA A CB 1 ATOM 1082 N N . ALA A 1 150 ? -16.672 -38.459 -16.713 1.00 33.15 ? 177 ALA A N 1 ATOM 1083 C CA . ALA A 1 150 ? -17.987 -38.524 -16.084 1.00 33.75 ? 177 ALA A CA 1 ATOM 1084 C C . ALA A 1 150 ? -18.649 -39.875 -16.360 1.00 33.25 ? 177 ALA A C 1 ATOM 1085 O O . ALA A 1 150 ? -19.229 -40.470 -15.454 1.00 35.38 ? 177 ALA A O 1 ATOM 1086 C CB . ALA A 1 150 ? -18.869 -37.376 -16.548 1.00 35.55 ? 177 ALA A CB 1 ATOM 1087 N N . LEU A 1 151 ? -18.546 -40.371 -17.596 1.00 32.73 ? 178 LEU A N 1 ATOM 1088 C CA . LEU A 1 151 ? -19.095 -41.708 -17.931 1.00 34.47 ? 178 LEU A CA 1 ATOM 1089 C C . LEU A 1 151 ? -18.444 -42.826 -17.103 1.00 37.42 ? 178 LEU A C 1 ATOM 1090 O O . LEU A 1 151 ? -19.133 -43.690 -16.543 1.00 37.47 ? 178 LEU A O 1 ATOM 1091 C CB . LEU A 1 151 ? -18.940 -42.002 -19.418 1.00 34.29 ? 178 LEU A CB 1 ATOM 1092 C CG . LEU A 1 151 ? -19.891 -41.204 -20.328 1.00 34.46 ? 178 LEU A CG 1 ATOM 1093 C CD1 . LEU A 1 151 ? -19.421 -41.200 -21.771 1.00 33.00 ? 178 LEU A CD1 1 ATOM 1094 C CD2 . LEU A 1 151 ? -21.318 -41.732 -20.228 1.00 33.48 ? 178 LEU A CD2 1 ATOM 1095 N N . GLU A 1 152 ? -17.124 -42.778 -16.993 1.00 41.16 ? 179 GLU A N 1 ATOM 1096 C CA . GLU A 1 152 ? -16.391 -43.717 -16.139 1.00 46.29 ? 179 GLU A CA 1 ATOM 1097 C C . GLU A 1 152 ? -16.900 -43.645 -14.707 1.00 43.68 ? 179 GLU A C 1 ATOM 1098 O O . GLU A 1 152 ? -17.210 -44.678 -14.119 1.00 39.29 ? 179 GLU A O 1 ATOM 1099 C CB . GLU A 1 152 ? -14.865 -43.443 -16.200 1.00 52.59 ? 179 GLU A CB 1 ATOM 1100 C CG . GLU A 1 152 ? -13.984 -44.243 -15.231 1.00 57.80 ? 179 GLU A CG 1 ATOM 1101 C CD . GLU A 1 152 ? -14.231 -45.748 -15.276 1.00 67.57 ? 179 GLU A CD 1 ATOM 1102 O OE1 . GLU A 1 152 ? -14.648 -46.276 -16.338 1.00 69.70 ? 179 GLU A OE1 1 ATOM 1103 O OE2 . GLU A 1 152 ? -14.012 -46.412 -14.236 1.00 78.17 ? 179 GLU A OE2 1 ATOM 1104 N N . ASN A 1 153 ? -17.011 -42.424 -14.170 1.00 44.00 ? 180 ASN A N 1 ATOM 1105 C CA . ASN A 1 153 ? -17.473 -42.217 -12.787 1.00 41.92 ? 180 ASN A CA 1 ATOM 1106 C C . ASN A 1 153 ? -18.824 -42.830 -12.491 1.00 41.16 ? 180 ASN A C 1 ATOM 1107 O O . ASN A 1 153 ? -19.025 -43.352 -11.403 1.00 41.28 ? 180 ASN A O 1 ATOM 1108 C CB . ASN A 1 153 ? -17.496 -40.725 -12.436 1.00 46.94 ? 180 ASN A CB 1 ATOM 1109 C CG . ASN A 1 153 ? -17.945 -40.458 -10.996 1.00 47.87 ? 180 ASN A CG 1 ATOM 1110 O OD1 . ASN A 1 153 ? -19.130 -40.460 -10.680 1.00 55.42 ? 180 ASN A OD1 1 ATOM 1111 N ND2 . ASN A 1 153 ? -16.996 -40.229 -10.131 1.00 48.96 ? 180 ASN A ND2 1 ATOM 1112 N N . LYS A 1 154 ? -19.743 -42.787 -13.459 1.00 43.76 ? 181 LYS A N 1 ATOM 1113 C CA . LYS A 1 154 ? -21.101 -43.320 -13.268 1.00 44.81 ? 181 LYS A CA 1 ATOM 1114 C C . LYS A 1 154 ? -21.340 -44.549 -14.136 1.00 44.33 ? 181 LYS A C 1 ATOM 1115 O O . LYS A 1 154 ? -22.481 -44.839 -14.528 1.00 41.68 ? 181 LYS A O 1 ATOM 1116 C CB . LYS A 1 154 ? -22.144 -42.240 -13.599 1.00 47.32 ? 181 LYS A CB 1 ATOM 1117 C CG . LYS A 1 154 ? -22.062 -41.015 -12.713 1.00 52.45 ? 181 LYS A CG 1 ATOM 1118 C CD . LYS A 1 154 ? -22.598 -41.291 -11.316 1.00 57.61 ? 181 LYS A CD 1 ATOM 1119 C CE . LYS A 1 154 ? -22.181 -40.184 -10.362 1.00 63.04 ? 181 LYS A CE 1 ATOM 1120 N NZ . LYS A 1 154 ? -22.412 -40.547 -8.939 1.00 67.33 ? 181 LYS A NZ 1 ATOM 1121 N N . ARG A 1 155 ? -20.257 -45.258 -14.439 1.00 44.82 ? 182 ARG A N 1 ATOM 1122 C CA A ARG A 1 155 ? -20.311 -46.422 -15.320 0.50 47.25 ? 182 ARG A CA 1 ATOM 1123 C CA B ARG A 1 155 ? -20.306 -46.412 -15.321 0.50 47.38 ? 182 ARG A CA 1 ATOM 1124 C C . ARG A 1 155 ? -21.447 -47.349 -14.933 1.00 46.40 ? 182 ARG A C 1 ATOM 1125 O O . ARG A 1 155 ? -22.255 -47.726 -15.763 1.00 47.24 ? 182 ARG A O 1 ATOM 1126 C CB A ARG A 1 155 ? -18.986 -47.201 -15.283 0.50 49.62 ? 182 ARG A CB 1 ATOM 1127 C CB B ARG A 1 155 ? -18.948 -47.131 -15.278 0.50 49.87 ? 182 ARG A CB 1 ATOM 1128 C CG A ARG A 1 155 ? -19.041 -48.550 -16.004 0.50 52.14 ? 182 ARG A CG 1 ATOM 1129 C CG B ARG A 1 155 ? -18.834 -48.404 -16.105 0.50 52.90 ? 182 ARG A CG 1 ATOM 1130 C CD A ARG A 1 155 ? -17.782 -49.385 -15.806 0.50 52.44 ? 182 ARG A CD 1 ATOM 1131 C CD B ARG A 1 155 ? -17.384 -48.879 -16.156 0.50 53.24 ? 182 ARG A CD 1 ATOM 1132 N NE A ARG A 1 155 ? -16.613 -48.733 -16.381 0.50 51.19 ? 182 ARG A NE 1 ATOM 1133 N NE B ARG A 1 155 ? -16.687 -48.641 -14.890 0.50 52.91 ? 182 ARG A NE 1 ATOM 1134 C CZ A ARG A 1 155 ? -16.296 -48.776 -17.666 0.50 50.33 ? 182 ARG A CZ 1 ATOM 1135 C CZ B ARG A 1 155 ? -16.520 -49.560 -13.946 0.50 52.51 ? 182 ARG A CZ 1 ATOM 1136 N NH1 A ARG A 1 155 ? -17.061 -49.448 -18.517 0.50 50.49 ? 182 ARG A NH1 1 ATOM 1137 N NH1 B ARG A 1 155 ? -16.997 -50.787 -14.120 0.50 52.05 ? 182 ARG A NH1 1 ATOM 1138 N NH2 A ARG A 1 155 ? -15.212 -48.148 -18.098 0.50 51.63 ? 182 ARG A NH2 1 ATOM 1139 N NH2 B ARG A 1 155 ? -15.874 -49.252 -12.829 0.50 51.57 ? 182 ARG A NH2 1 ATOM 1140 N N . THR A 1 156 ? -21.506 -47.710 -13.659 1.00 49.55 ? 183 THR A N 1 ATOM 1141 C CA . THR A 1 156 ? -22.477 -48.686 -13.199 1.00 51.58 ? 183 THR A CA 1 ATOM 1142 C C . THR A 1 156 ? -23.924 -48.269 -13.444 1.00 54.09 ? 183 THR A C 1 ATOM 1143 O O . THR A 1 156 ? -24.709 -49.051 -14.003 1.00 51.56 ? 183 THR A O 1 ATOM 1144 C CB . THR A 1 156 ? -22.319 -48.992 -11.696 1.00 54.48 ? 183 THR A CB 1 ATOM 1145 O OG1 . THR A 1 156 ? -20.955 -49.313 -11.410 1.00 56.14 ? 183 THR A OG1 1 ATOM 1146 C CG2 . THR A 1 156 ? -23.218 -50.177 -11.292 1.00 55.30 ? 183 THR A CG2 1 ATOM 1147 N N . VAL A 1 157 ? -24.292 -47.064 -12.998 1.00 54.85 ? 184 VAL A N 1 ATOM 1148 C CA . VAL A 1 157 ? -25.695 -46.627 -13.106 1.00 55.42 ? 184 VAL A CA 1 ATOM 1149 C C . VAL A 1 157 ? -26.100 -46.494 -14.564 1.00 49.52 ? 184 VAL A C 1 ATOM 1150 O O . VAL A 1 157 ? -27.211 -46.844 -14.921 1.00 49.38 ? 184 VAL A O 1 ATOM 1151 C CB . VAL A 1 157 ? -26.018 -45.325 -12.321 1.00 60.29 ? 184 VAL A CB 1 ATOM 1152 C CG1 . VAL A 1 157 ? -25.265 -44.124 -12.868 1.00 64.19 ? 184 VAL A CG1 1 ATOM 1153 C CG2 . VAL A 1 157 ? -27.511 -45.039 -12.365 1.00 62.85 ? 184 VAL A CG2 1 ATOM 1154 N N . ILE A 1 158 ? -25.179 -46.026 -15.399 1.00 45.00 ? 185 ILE A N 1 ATOM 1155 C CA . ILE A 1 158 ? -25.450 -45.867 -16.819 1.00 45.52 ? 185 ILE A CA 1 ATOM 1156 C C . ILE A 1 158 ? -25.593 -47.201 -17.546 1.00 47.80 ? 185 ILE A C 1 ATOM 1157 O O . ILE A 1 158 ? -26.524 -47.380 -18.339 1.00 45.35 ? 185 ILE A O 1 ATOM 1158 C CB . ILE A 1 158 ? -24.373 -44.983 -17.487 1.00 43.94 ? 185 ILE A CB 1 ATOM 1159 C CG1 . ILE A 1 158 ? -24.623 -43.529 -17.069 1.00 45.67 ? 185 ILE A CG1 1 ATOM 1160 C CG2 . ILE A 1 158 ? -24.390 -45.149 -18.990 1.00 42.11 ? 185 ILE A CG2 1 ATOM 1161 C CD1 . ILE A 1 158 ? -23.771 -42.503 -17.756 1.00 48.39 ? 185 ILE A CD1 1 ATOM 1162 N N . GLU A 1 159 ? -24.682 -48.132 -17.272 1.00 48.72 ? 186 GLU A N 1 ATOM 1163 C CA . GLU A 1 159 ? -24.701 -49.434 -17.943 1.00 51.31 ? 186 GLU A CA 1 ATOM 1164 C C . GLU A 1 159 ? -25.928 -50.229 -17.547 1.00 49.27 ? 186 GLU A C 1 ATOM 1165 O O . GLU A 1 159 ? -26.458 -50.966 -18.346 1.00 55.08 ? 186 GLU A O 1 ATOM 1166 C CB . GLU A 1 159 ? -23.416 -50.238 -17.646 1.00 52.82 ? 186 GLU A CB 1 ATOM 1167 C CG . GLU A 1 159 ? -22.191 -49.726 -18.401 1.00 54.25 ? 186 GLU A CG 1 ATOM 1168 C CD . GLU A 1 159 ? -20.879 -50.394 -18.003 1.00 57.80 ? 186 GLU A CD 1 ATOM 1169 O OE1 . GLU A 1 159 ? -20.854 -51.199 -17.047 1.00 65.40 ? 186 GLU A OE1 1 ATOM 1170 O OE2 . GLU A 1 159 ? -19.850 -50.094 -18.642 1.00 57.78 ? 186 GLU A OE2 1 ATOM 1171 N N . GLN A 1 160 ? -26.400 -50.069 -16.323 1.00 52.66 ? 187 GLN A N 1 ATOM 1172 C CA . GLN A 1 160 ? -27.573 -50.819 -15.879 1.00 59.36 ? 187 GLN A CA 1 ATOM 1173 C C . GLN A 1 160 ? -28.911 -50.130 -16.216 1.00 59.76 ? 187 GLN A C 1 ATOM 1174 O O . GLN A 1 160 ? -29.975 -50.682 -15.949 1.00 57.46 ? 187 GLN A O 1 ATOM 1175 C CB . GLN A 1 160 ? -27.467 -51.114 -14.378 1.00 64.89 ? 187 GLN A CB 1 ATOM 1176 C CG . GLN A 1 160 ? -27.820 -49.942 -13.468 1.00 71.49 ? 187 GLN A CG 1 ATOM 1177 C CD . GLN A 1 160 ? -27.396 -50.162 -12.023 1.00 76.30 ? 187 GLN A CD 1 ATOM 1178 O OE1 . GLN A 1 160 ? -26.987 -51.264 -11.635 1.00 82.42 ? 187 GLN A OE1 1 ATOM 1179 N NE2 . GLN A 1 160 ? -27.496 -49.107 -11.214 1.00 75.89 ? 187 GLN A NE2 1 ATOM 1180 N N . GLN A 1 161 ? -28.857 -48.930 -16.797 1.00 60.22 ? 188 GLN A N 1 ATOM 1181 C CA . GLN A 1 161 ? -30.066 -48.198 -17.203 1.00 58.90 ? 188 GLN A CA 1 ATOM 1182 C C . GLN A 1 161 ? -30.176 -48.149 -18.743 1.00 54.20 ? 188 GLN A C 1 ATOM 1183 O O . GLN A 1 161 ? -29.444 -47.412 -19.407 1.00 52.47 ? 188 GLN A O 1 ATOM 1184 C CB . GLN A 1 161 ? -30.069 -46.792 -16.587 1.00 59.89 ? 188 GLN A CB 1 ATOM 1185 C CG . GLN A 1 161 ? -31.175 -45.870 -17.095 1.00 66.24 ? 188 GLN A CG 1 ATOM 1186 C CD . GLN A 1 161 ? -32.576 -46.423 -16.874 1.00 69.12 ? 188 GLN A CD 1 ATOM 1187 O OE1 . GLN A 1 161 ? -33.371 -46.567 -17.821 1.00 62.45 ? 188 GLN A OE1 1 ATOM 1188 N NE2 . GLN A 1 161 ? -32.887 -46.733 -15.614 1.00 68.60 ? 188 GLN A NE2 1 ATOM 1189 N N . PRO A 1 162 ? -31.100 -48.936 -19.318 1.00 52.62 ? 189 PRO A N 1 ATOM 1190 C CA . PRO A 1 162 ? -31.121 -49.086 -20.774 1.00 49.87 ? 189 PRO A CA 1 ATOM 1191 C C . PRO A 1 162 ? -31.427 -47.805 -21.565 1.00 43.41 ? 189 PRO A C 1 ATOM 1192 O O . PRO A 1 162 ? -30.851 -47.622 -22.633 1.00 39.04 ? 189 PRO A O 1 ATOM 1193 C CB . PRO A 1 162 ? -32.211 -50.147 -21.015 1.00 52.10 ? 189 PRO A CB 1 ATOM 1194 C CG . PRO A 1 162 ? -32.442 -50.792 -19.689 1.00 54.14 ? 189 PRO A CG 1 ATOM 1195 C CD . PRO A 1 162 ? -32.152 -49.739 -18.668 1.00 54.86 ? 189 PRO A CD 1 ATOM 1196 N N . VAL A 1 163 ? -32.302 -46.931 -21.063 1.00 37.25 ? 190 VAL A N 1 ATOM 1197 C CA . VAL A 1 163 ? -32.574 -45.663 -21.776 1.00 38.40 ? 190 VAL A CA 1 ATOM 1198 C C . VAL A 1 163 ? -31.351 -44.732 -21.830 1.00 36.16 ? 190 VAL A C 1 ATOM 1199 O O . VAL A 1 163 ? -31.165 -44.054 -22.813 1.00 36.34 ? 190 VAL A O 1 ATOM 1200 C CB . VAL A 1 163 ? -33.817 -44.930 -21.231 1.00 40.15 ? 190 VAL A CB 1 ATOM 1201 C CG1 . VAL A 1 163 ? -34.053 -43.642 -21.996 1.00 39.95 ? 190 VAL A CG1 1 ATOM 1202 C CG2 . VAL A 1 163 ? -35.032 -45.842 -21.356 1.00 41.17 ? 190 VAL A CG2 1 ATOM 1203 N N . LEU A 1 164 ? -30.489 -44.747 -20.817 1.00 37.57 ? 191 LEU A N 1 ATOM 1204 C CA . LEU A 1 164 ? -29.218 -43.990 -20.864 1.00 37.44 ? 191 LEU A CA 1 ATOM 1205 C C . LEU A 1 164 ? -28.149 -44.702 -21.710 1.00 39.54 ? 191 LEU A C 1 ATOM 1206 O O . LEU A 1 164 ? -27.390 -44.061 -22.468 1.00 35.75 ? 191 LEU A O 1 ATOM 1207 C CB . LEU A 1 164 ? -28.645 -43.790 -19.457 1.00 37.24 ? 191 LEU A CB 1 ATOM 1208 C CG . LEU A 1 164 ? -29.233 -42.682 -18.585 1.00 38.31 ? 191 LEU A CG 1 ATOM 1209 C CD1 . LEU A 1 164 ? -28.693 -42.798 -17.163 1.00 37.74 ? 191 LEU A CD1 1 ATOM 1210 C CD2 . LEU A 1 164 ? -28.955 -41.296 -19.157 1.00 36.51 ? 191 LEU A CD2 1 ATOM 1211 N N . CYS A 1 165 ? -28.070 -46.026 -21.568 1.00 43.15 ? 192 CYS A N 1 ATOM 1212 C CA . CYS A 1 165 ? -27.075 -46.825 -22.308 1.00 46.16 ? 192 CYS A CA 1 ATOM 1213 C C . CYS A 1 165 ? -27.315 -46.765 -23.835 1.00 43.51 ? 192 CYS A C 1 ATOM 1214 O O . CYS A 1 165 ? -26.375 -46.806 -24.636 1.00 40.45 ? 192 CYS A O 1 ATOM 1215 C CB . CYS A 1 165 ? -27.087 -48.272 -21.790 1.00 51.88 ? 192 CYS A CB 1 ATOM 1216 S SG . CYS A 1 165 ? -25.548 -49.225 -21.978 1.00 66.85 ? 192 CYS A SG 1 ATOM 1217 N N . GLU A 1 166 ? -28.588 -46.649 -24.204 1.00 42.64 ? 193 GLU A N 1 ATOM 1218 C CA . GLU A 1 166 ? -29.030 -46.382 -25.571 1.00 45.21 ? 193 GLU A CA 1 ATOM 1219 C C . GLU A 1 166 ? -28.119 -45.392 -26.291 1.00 41.81 ? 193 GLU A C 1 ATOM 1220 O O . GLU A 1 166 ? -27.769 -45.632 -27.442 1.00 40.87 ? 193 GLU A O 1 ATOM 1221 C CB . GLU A 1 166 ? -30.465 -45.824 -25.534 1.00 51.67 ? 193 GLU A CB 1 ATOM 1222 C CG . GLU A 1 166 ? -31.129 -45.573 -26.878 1.00 60.72 ? 193 GLU A CG 1 ATOM 1223 C CD . GLU A 1 166 ? -31.997 -46.738 -27.347 1.00 73.28 ? 193 GLU A CD 1 ATOM 1224 O OE1 . GLU A 1 166 ? -32.985 -47.083 -26.646 1.00 83.16 ? 193 GLU A OE1 1 ATOM 1225 O OE2 . GLU A 1 166 ? -31.701 -47.299 -28.429 1.00 76.49 ? 193 GLU A OE2 1 ATOM 1226 N N . VAL A 1 167 ? -27.771 -44.277 -25.635 1.00 36.20 ? 194 VAL A N 1 ATOM 1227 C CA . VAL A 1 167 ? -26.909 -43.265 -26.245 1.00 35.62 ? 194 VAL A CA 1 ATOM 1228 C C . VAL A 1 167 ? -25.517 -43.201 -25.634 1.00 34.67 ? 194 VAL A C 1 ATOM 1229 O O . VAL A 1 167 ? -24.557 -42.822 -26.321 1.00 33.98 ? 194 VAL A O 1 ATOM 1230 C CB . VAL A 1 167 ? -27.517 -41.839 -26.246 1.00 33.73 ? 194 VAL A CB 1 ATOM 1231 C CG1 . VAL A 1 167 ? -28.797 -41.835 -27.057 1.00 33.83 ? 194 VAL A CG1 1 ATOM 1232 C CG2 . VAL A 1 167 ? -27.741 -41.303 -24.832 1.00 32.85 ? 194 VAL A CG2 1 ATOM 1233 N N . PHE A 1 168 ? -25.388 -43.533 -24.358 1.00 35.52 ? 195 PHE A N 1 ATOM 1234 C CA . PHE A 1 168 ? -24.084 -43.363 -23.703 1.00 36.45 ? 195 PHE A CA 1 ATOM 1235 C C . PHE A 1 168 ? -23.205 -44.617 -23.671 1.00 39.86 ? 195 PHE A C 1 ATOM 1236 O O . PHE A 1 168 ? -22.131 -44.600 -23.062 1.00 38.92 ? 195 PHE A O 1 ATOM 1237 C CB . PHE A 1 168 ? -24.273 -42.795 -22.305 1.00 35.26 ? 195 PHE A CB 1 ATOM 1238 C CG . PHE A 1 168 ? -24.786 -41.381 -22.302 1.00 33.48 ? 195 PHE A CG 1 ATOM 1239 C CD1 . PHE A 1 168 ? -24.062 -40.377 -22.911 1.00 31.61 ? 195 PHE A CD1 1 ATOM 1240 C CD2 . PHE A 1 168 ? -25.991 -41.062 -21.682 1.00 32.39 ? 195 PHE A CD2 1 ATOM 1241 C CE1 . PHE A 1 168 ? -24.525 -39.071 -22.918 1.00 32.41 ? 195 PHE A CE1 1 ATOM 1242 C CE2 . PHE A 1 168 ? -26.463 -39.757 -21.686 1.00 32.89 ? 195 PHE A CE2 1 ATOM 1243 C CZ . PHE A 1 168 ? -25.721 -38.759 -22.305 1.00 33.75 ? 195 PHE A CZ 1 ATOM 1244 N N . CYS A 1 169 ? -23.648 -45.695 -24.323 1.00 43.32 ? 196 CYS A N 1 ATOM 1245 C CA . CYS A 1 169 ? -22.810 -46.894 -24.466 1.00 49.50 ? 196 CYS A CA 1 ATOM 1246 C C . CYS A 1 169 ? -22.508 -47.273 -25.905 1.00 49.90 ? 196 CYS A C 1 ATOM 1247 O O . CYS A 1 169 ? -23.125 -46.781 -26.847 1.00 48.51 ? 196 CYS A O 1 ATOM 1248 C CB . CYS A 1 169 ? -23.458 -48.101 -23.800 1.00 49.59 ? 196 CYS A CB 1 ATOM 1249 S SG . CYS A 1 169 ? -23.911 -47.912 -22.067 1.00 52.50 ? 196 CYS A SG 1 ATOM 1250 N N . ARG A 1 170 ? -21.516 -48.145 -26.036 1.00 61.34 ? 197 ARG A N 1 ATOM 1251 C CA . ARG A 1 170 ? -21.193 -48.847 -27.271 1.00 68.09 ? 197 ARG A CA 1 ATOM 1252 C C . ARG A 1 170 ? -20.962 -50.294 -26.857 1.00 68.18 ? 197 ARG A C 1 ATOM 1253 O O . ARG A 1 170 ? -20.035 -50.581 -26.097 1.00 62.54 ? 197 ARG A O 1 ATOM 1254 C CB . ARG A 1 170 ? -19.934 -48.270 -27.916 1.00 75.39 ? 197 ARG A CB 1 ATOM 1255 C CG . ARG A 1 170 ? -19.671 -48.756 -29.338 1.00 84.31 ? 197 ARG A CG 1 ATOM 1256 C CD . ARG A 1 170 ? -18.519 -47.993 -29.984 1.00 88.99 ? 197 ARG A CD 1 ATOM 1257 N NE . ARG A 1 170 ? -17.275 -48.766 -30.022 1.00 94.97 ? 197 ARG A NE 1 ATOM 1258 C CZ . ARG A 1 170 ? -16.635 -49.147 -31.132 1.00 99.72 ? 197 ARG A CZ 1 ATOM 1259 N NH1 . ARG A 1 170 ? -17.090 -48.831 -32.347 1.00 102.02 ? 197 ARG A NH1 1 ATOM 1260 N NH2 . ARG A 1 170 ? -15.514 -49.850 -31.025 1.00 98.77 ? 197 ARG A NH2 1 ATOM 1261 N N . ASP A 1 171 ? -21.834 -51.186 -27.326 1.00 72.54 ? 198 ASP A N 1 ATOM 1262 C CA . ASP A 1 171 ? -21.781 -52.617 -26.993 1.00 75.03 ? 198 ASP A CA 1 ATOM 1263 C C . ASP A 1 171 ? -21.907 -52.823 -25.495 1.00 69.48 ? 198 ASP A C 1 ATOM 1264 O O . ASP A 1 171 ? -21.079 -53.496 -24.877 1.00 69.39 ? 198 ASP A O 1 ATOM 1265 C CB . ASP A 1 171 ? -20.497 -53.280 -27.530 1.00 80.34 ? 198 ASP A CB 1 ATOM 1266 C CG . ASP A 1 171 ? -20.324 -53.094 -29.040 1.00 88.85 ? 198 ASP A CG 1 ATOM 1267 O OD1 . ASP A 1 171 ? -21.350 -53.089 -29.759 1.00 93.99 ? 198 ASP A OD1 1 ATOM 1268 O OD2 . ASP A 1 171 ? -19.166 -52.954 -29.509 1.00 85.97 ? 198 ASP A OD2 1 ATOM 1269 N N . ARG A 1 172 ? -22.954 -52.229 -24.925 1.00 65.79 ? 199 ARG A N 1 ATOM 1270 C CA . ARG A 1 172 ? -23.286 -52.364 -23.502 1.00 62.62 ? 199 ARG A CA 1 ATOM 1271 C C . ARG A 1 172 ? -22.321 -51.726 -22.494 1.00 56.58 ? 199 ARG A C 1 ATOM 1272 O O . ARG A 1 172 ? -22.564 -51.794 -21.289 1.00 54.49 ? 199 ARG A O 1 ATOM 1273 C CB . ARG A 1 172 ? -23.493 -53.848 -23.165 1.00 65.88 ? 199 ARG A CB 1 ATOM 1274 C CG . ARG A 1 172 ? -24.690 -54.497 -23.861 1.00 66.85 ? 199 ARG A CG 1 ATOM 1275 C CD . ARG A 1 172 ? -24.779 -55.989 -23.560 1.00 66.49 ? 199 ARG A CD 1 ATOM 1276 N N . LYS A 1 173 ? -21.246 -51.086 -22.964 1.00 55.19 ? 200 LYS A N 1 ATOM 1277 C CA . LYS A 1 173 ? -20.231 -50.479 -22.091 1.00 57.60 ? 200 LYS A CA 1 ATOM 1278 C C . LYS A 1 173 ? -20.116 -48.967 -22.352 1.00 52.05 ? 200 LYS A C 1 ATOM 1279 O O . LYS A 1 173 ? -20.181 -48.527 -23.501 1.00 48.80 ? 200 LYS A O 1 ATOM 1280 C CB . LYS A 1 173 ? -18.857 -51.135 -22.325 1.00 65.99 ? 200 LYS A CB 1 ATOM 1281 C CG . LYS A 1 173 ? -18.816 -52.658 -22.151 1.00 77.33 ? 200 LYS A CG 1 ATOM 1282 C CD . LYS A 1 173 ? -18.716 -53.092 -20.688 1.00 83.67 ? 200 LYS A CD 1 ATOM 1283 C CE . LYS A 1 173 ? -17.270 -53.119 -20.201 1.00 90.17 ? 200 LYS A CE 1 ATOM 1284 N NZ . LYS A 1 173 ? -17.170 -53.095 -18.713 1.00 94.49 ? 200 LYS A NZ 1 ATOM 1285 N N . VAL A 1 174 ? -19.901 -48.170 -21.307 1.00 46.68 ? 201 VAL A N 1 ATOM 1286 C CA . VAL A 1 174 ? -19.865 -46.721 -21.490 1.00 45.26 ? 201 VAL A CA 1 ATOM 1287 C C . VAL A 1 174 ? -18.818 -46.306 -22.504 1.00 42.85 ? 201 VAL A C 1 ATOM 1288 O O . VAL A 1 174 ? -17.744 -46.892 -22.558 1.00 44.99 ? 201 VAL A O 1 ATOM 1289 C CB . VAL A 1 174 ? -19.588 -45.928 -20.193 1.00 45.17 ? 201 VAL A CB 1 ATOM 1290 C CG1 . VAL A 1 174 ? -20.699 -46.140 -19.188 1.00 43.68 ? 201 VAL A CG1 1 ATOM 1291 C CG2 . VAL A 1 174 ? -18.200 -46.251 -19.621 1.00 46.45 ? 201 VAL A CG2 1 ATOM 1292 N N . LEU A 1 175 ? -19.141 -45.272 -23.277 1.00 38.32 ? 202 LEU A N 1 ATOM 1293 C CA . LEU A 1 175 ? -18.246 -44.739 -24.265 1.00 38.54 ? 202 LEU A CA 1 ATOM 1294 C C . LEU A 1 175 ? -17.006 -44.196 -23.592 1.00 42.08 ? 202 LEU A C 1 ATOM 1295 O O . LEU A 1 175 ? -17.061 -43.736 -22.433 1.00 42.92 ? 202 LEU A O 1 ATOM 1296 C CB . LEU A 1 175 ? -18.906 -43.587 -25.016 1.00 40.13 ? 202 LEU A CB 1 ATOM 1297 C CG . LEU A 1 175 ? -20.112 -43.940 -25.887 1.00 42.43 ? 202 LEU A CG 1 ATOM 1298 C CD1 . LEU A 1 175 ? -20.913 -42.696 -26.264 1.00 39.69 ? 202 LEU A CD1 1 ATOM 1299 C CD2 . LEU A 1 175 ? -19.640 -44.676 -27.131 1.00 42.66 ? 202 LEU A CD2 1 ATOM 1300 N N . ARG A 1 176 ? -15.905 -44.201 -24.337 1.00 41.34 ? 203 ARG A N 1 ATOM 1301 C CA . ARG A 1 176 ? -14.629 -43.698 -23.860 1.00 44.22 ? 203 ARG A CA 1 ATOM 1302 C C . ARG A 1 176 ? -14.205 -42.535 -24.727 1.00 39.72 ? 203 ARG A C 1 ATOM 1303 O O . ARG A 1 176 ? -14.810 -42.290 -25.768 1.00 39.12 ? 203 ARG A O 1 ATOM 1304 C CB . ARG A 1 176 ? -13.589 -44.816 -23.886 1.00 49.24 ? 203 ARG A CB 1 ATOM 1305 C CG . ARG A 1 176 ? -13.795 -45.820 -22.767 1.00 56.32 ? 203 ARG A CG 1 ATOM 1306 C CD . ARG A 1 176 ? -12.879 -47.016 -22.904 1.00 60.73 ? 203 ARG A CD 1 ATOM 1307 N NE . ARG A 1 176 ? -13.315 -47.884 -23.991 1.00 68.01 ? 203 ARG A NE 1 ATOM 1308 C CZ . ARG A 1 176 ? -12.569 -48.832 -24.561 1.00 77.24 ? 203 ARG A CZ 1 ATOM 1309 N NH1 . ARG A 1 176 ? -11.317 -49.069 -24.156 1.00 77.72 ? 203 ARG A NH1 1 ATOM 1310 N NH2 . ARG A 1 176 ? -13.085 -49.551 -25.554 1.00 75.64 ? 203 ARG A NH2 1 ATOM 1311 N N . GLU A 1 177 ? -13.173 -41.813 -24.297 1.00 39.32 ? 204 GLU A N 1 ATOM 1312 C CA . GLU A 1 177 ? -12.686 -40.663 -25.061 1.00 40.33 ? 204 GLU A CA 1 ATOM 1313 C C . GLU A 1 177 ? -12.292 -41.114 -26.457 1.00 40.20 ? 204 GLU A C 1 ATOM 1314 O O . GLU A 1 177 ? -11.698 -42.173 -26.615 1.00 46.15 ? 204 GLU A O 1 ATOM 1315 C CB . GLU A 1 177 ? -11.509 -39.969 -24.369 1.00 42.54 ? 204 GLU A CB 1 ATOM 1316 C CG . GLU A 1 177 ? -10.968 -38.773 -25.152 1.00 46.58 ? 204 GLU A CG 1 ATOM 1317 C CD . GLU A 1 177 ? -9.977 -37.905 -24.376 1.00 47.53 ? 204 GLU A CD 1 ATOM 1318 O OE1 . GLU A 1 177 ? -9.611 -38.269 -23.243 1.00 46.15 ? 204 GLU A OE1 1 ATOM 1319 O OE2 . GLU A 1 177 ? -9.574 -36.842 -24.915 1.00 51.15 ? 204 GLU A OE2 1 ATOM 1320 N N . GLY A 1 178 ? -12.650 -40.317 -27.459 1.00 38.50 ? 205 GLY A N 1 ATOM 1321 C CA . GLY A 1 178 ? -12.453 -40.676 -28.849 1.00 37.30 ? 205 GLY A CA 1 ATOM 1322 C C . GLY A 1 178 ? -13.653 -41.350 -29.522 1.00 37.51 ? 205 GLY A C 1 ATOM 1323 O O . GLY A 1 178 ? -13.854 -41.137 -30.704 1.00 38.61 ? 205 GLY A O 1 ATOM 1324 N N . GLU A 1 179 ? -14.452 -42.141 -28.791 1.00 35.73 ? 206 GLU A N 1 ATOM 1325 C CA . GLU A 1 179 ? -15.562 -42.889 -29.397 1.00 35.51 ? 206 GLU A CA 1 ATOM 1326 C C . GLU A 1 179 ? -16.723 -41.957 -29.780 1.00 39.47 ? 206 GLU A C 1 ATOM 1327 O O . GLU A 1 179 ? -16.868 -40.853 -29.232 1.00 39.10 ? 206 GLU A O 1 ATOM 1328 C CB . GLU A 1 179 ? -16.025 -44.013 -28.464 1.00 38.33 ? 206 GLU A CB 1 ATOM 1329 C CG . GLU A 1 179 ? -14.920 -45.028 -28.171 1.00 43.18 ? 206 GLU A CG 1 ATOM 1330 C CD . GLU A 1 179 ? -15.356 -46.259 -27.382 1.00 46.61 ? 206 GLU A CD 1 ATOM 1331 O OE1 . GLU A 1 179 ? -16.299 -46.188 -26.567 1.00 50.36 ? 206 GLU A OE1 1 ATOM 1332 O OE2 . GLU A 1 179 ? -14.721 -47.323 -27.557 1.00 54.16 ? 206 GLU A OE2 1 ATOM 1333 N N . ARG A 1 180 ? -17.548 -42.380 -30.729 1.00 41.28 ? 207 ARG A N 1 ATOM 1334 C CA . ARG A 1 180 ? -18.547 -41.466 -31.295 1.00 45.10 ? 207 ARG A CA 1 ATOM 1335 C C . ARG A 1 180 ? -19.838 -41.468 -30.465 1.00 40.10 ? 207 ARG A C 1 ATOM 1336 O O . ARG A 1 180 ? -20.404 -42.518 -30.177 1.00 37.90 ? 207 ARG A O 1 ATOM 1337 C CB . ARG A 1 180 ? -18.823 -41.787 -32.777 1.00 48.79 ? 207 ARG A CB 1 ATOM 1338 C CG . ARG A 1 180 ? -19.741 -40.778 -33.485 1.00 54.19 ? 207 ARG A CG 1 ATOM 1339 C CD . ARG A 1 180 ? -19.459 -40.666 -34.982 1.00 56.19 ? 207 ARG A CD 1 ATOM 1340 N NE . ARG A 1 180 ? -18.179 -39.993 -35.234 1.00 62.31 ? 207 ARG A NE 1 ATOM 1341 C CZ . ARG A 1 180 ? -18.014 -38.719 -35.612 1.00 61.85 ? 207 ARG A CZ 1 ATOM 1342 N NH1 . ARG A 1 180 ? -19.045 -37.908 -35.829 1.00 63.20 ? 207 ARG A NH1 1 ATOM 1343 N NH2 . ARG A 1 180 ? -16.787 -38.246 -35.787 1.00 66.08 ? 207 ARG A NH2 1 ATOM 1344 N N . LEU A 1 181 ? -20.275 -40.281 -30.055 1.00 38.10 ? 208 LEU A N 1 ATOM 1345 C CA . LEU A 1 181 ? -21.570 -40.133 -29.369 1.00 36.76 ? 208 LEU A CA 1 ATOM 1346 C C . LEU A 1 181 ? -22.526 -39.453 -30.339 1.00 33.58 ? 208 LEU A C 1 ATOM 1347 O O . LEU A 1 181 ? -22.182 -38.418 -30.930 1.00 33.36 ? 208 LEU A O 1 ATOM 1348 C CB . LEU A 1 181 ? -21.425 -39.304 -28.077 1.00 36.25 ? 208 LEU A CB 1 ATOM 1349 C CG . LEU A 1 181 ? -22.706 -38.743 -27.439 1.00 35.32 ? 208 LEU A CG 1 ATOM 1350 C CD1 . LEU A 1 181 ? -23.665 -39.882 -27.137 1.00 35.56 ? 208 LEU A CD1 1 ATOM 1351 C CD2 . LEU A 1 181 ? -22.435 -37.936 -26.170 1.00 34.61 ? 208 LEU A CD2 1 ATOM 1352 N N . THR A 1 182 ? -23.698 -40.061 -30.532 1.00 31.29 ? 209 THR A N 1 ATOM 1353 C CA A THR A 1 182 ? -24.770 -39.460 -31.341 0.50 30.60 ? 209 THR A CA 1 ATOM 1354 C CA B THR A 1 182 ? -24.757 -39.467 -31.333 0.50 30.81 ? 209 THR A CA 1 ATOM 1355 C C . THR A 1 182 ? -25.984 -39.303 -30.441 1.00 29.36 ? 209 THR A C 1 ATOM 1356 O O . THR A 1 182 ? -26.237 -40.141 -29.569 1.00 27.99 ? 209 THR A O 1 ATOM 1357 C CB A THR A 1 182 ? -25.112 -40.281 -32.624 0.50 31.51 ? 209 THR A CB 1 ATOM 1358 C CB B THR A 1 182 ? -25.077 -40.338 -32.564 0.50 31.58 ? 209 THR A CB 1 ATOM 1359 O OG1 A THR A 1 182 ? -26.029 -39.551 -33.463 0.50 30.81 ? 209 THR A OG1 1 ATOM 1360 O OG1 B THR A 1 182 ? -25.454 -41.649 -32.135 0.50 36.80 ? 209 THR A OG1 1 ATOM 1361 C CG2 A THR A 1 182 ? -25.738 -41.623 -32.285 0.50 33.73 ? 209 THR A CG2 1 ATOM 1362 C CG2 B THR A 1 182 ? -23.862 -40.440 -33.493 0.50 30.67 ? 209 THR A CG2 1 ATOM 1363 N N . LEU A 1 183 ? -26.722 -38.212 -30.647 1.00 28.75 ? 210 LEU A N 1 ATOM 1364 C CA . LEU A 1 183 ? -27.844 -37.839 -29.778 1.00 27.49 ? 210 LEU A CA 1 ATOM 1365 C C . LEU A 1 183 ? -29.038 -37.541 -30.672 1.00 28.58 ? 210 LEU A C 1 ATOM 1366 O O . LEU A 1 183 ? -29.411 -36.383 -30.866 1.00 28.96 ? 210 LEU A O 1 ATOM 1367 C CB . LEU A 1 183 ? -27.447 -36.627 -28.910 1.00 27.43 ? 210 LEU A CB 1 ATOM 1368 C CG . LEU A 1 183 ? -26.381 -36.895 -27.843 1.00 25.89 ? 210 LEU A CG 1 ATOM 1369 C CD1 . LEU A 1 183 ? -25.859 -35.609 -27.234 1.00 27.62 ? 210 LEU A CD1 1 ATOM 1370 C CD2 . LEU A 1 183 ? -26.880 -37.808 -26.746 1.00 25.35 ? 210 LEU A CD2 1 ATOM 1371 N N . PRO A 1 184 ? -29.634 -38.605 -31.248 1.00 28.98 ? 211 PRO A N 1 ATOM 1372 C CA . PRO A 1 184 ? -30.571 -38.393 -32.353 1.00 28.58 ? 211 PRO A CA 1 ATOM 1373 C C . PRO A 1 184 ? -31.912 -37.878 -31.923 1.00 25.86 ? 211 PRO A C 1 ATOM 1374 O O . PRO A 1 184 ? -32.567 -37.167 -32.682 1.00 27.09 ? 211 PRO A O 1 ATOM 1375 C CB . PRO A 1 184 ? -30.686 -39.782 -33.034 1.00 27.35 ? 211 PRO A CB 1 ATOM 1376 C CG . PRO A 1 184 ? -30.166 -40.763 -32.061 1.00 28.17 ? 211 PRO A CG 1 ATOM 1377 C CD . PRO A 1 184 ? -29.364 -40.031 -30.998 1.00 27.41 ? 211 PRO A CD 1 ATOM 1378 N N . GLN A 1 185 ? -32.344 -38.255 -30.735 1.00 27.96 ? 212 GLN A N 1 ATOM 1379 C CA . GLN A 1 185 ? -33.587 -37.725 -30.196 1.00 28.03 ? 212 GLN A CA 1 ATOM 1380 C C . GLN A 1 185 ? -33.467 -36.253 -29.799 1.00 25.91 ? 212 GLN A C 1 ATOM 1381 O O . GLN A 1 185 ? -34.358 -35.455 -30.084 1.00 28.35 ? 212 GLN A O 1 ATOM 1382 C CB . GLN A 1 185 ? -34.086 -38.599 -29.038 1.00 31.43 ? 212 GLN A CB 1 ATOM 1383 C CG . GLN A 1 185 ? -34.792 -39.878 -29.521 1.00 32.60 ? 212 GLN A CG 1 ATOM 1384 C CD . GLN A 1 185 ? -33.830 -40.981 -29.879 1.00 33.41 ? 212 GLN A CD 1 ATOM 1385 O OE1 . GLN A 1 185 ? -32.828 -41.187 -29.219 1.00 36.91 ? 212 GLN A OE1 1 ATOM 1386 N NE2 . GLN A 1 185 ? -34.133 -41.695 -30.929 1.00 37.87 ? 212 GLN A NE2 1 ATOM 1387 N N . LEU A 1 186 ? -32.375 -35.880 -29.152 1.00 25.54 ? 213 LEU A N 1 ATOM 1388 C CA . LEU A 1 186 ? -32.156 -34.475 -28.824 1.00 26.10 ? 213 LEU A CA 1 ATOM 1389 C C . LEU A 1 186 ? -32.077 -33.626 -30.070 1.00 25.16 ? 213 LEU A C 1 ATOM 1390 O O . LEU A 1 186 ? -32.505 -32.467 -30.071 1.00 24.23 ? 213 LEU A O 1 ATOM 1391 C CB . LEU A 1 186 ? -30.869 -34.260 -28.001 1.00 26.26 ? 213 LEU A CB 1 ATOM 1392 C CG . LEU A 1 186 ? -31.052 -34.253 -26.491 1.00 27.44 ? 213 LEU A CG 1 ATOM 1393 C CD1 . LEU A 1 186 ? -29.733 -33.926 -25.807 1.00 27.85 ? 213 LEU A CD1 1 ATOM 1394 C CD2 . LEU A 1 186 ? -32.113 -33.234 -26.069 1.00 27.15 ? 213 LEU A CD2 1 ATOM 1395 N N . ALA A 1 187 ? -31.491 -34.165 -31.123 1.00 25.56 ? 214 ALA A N 1 ATOM 1396 C CA . ALA A 1 187 ? -31.437 -33.423 -32.376 1.00 26.68 ? 214 ALA A CA 1 ATOM 1397 C C . ALA A 1 187 ? -32.845 -33.038 -32.832 1.00 27.47 ? 214 ALA A C 1 ATOM 1398 O O . ALA A 1 187 ? -33.086 -31.899 -33.254 1.00 28.33 ? 214 ALA A O 1 ATOM 1399 C CB . ALA A 1 187 ? -30.743 -34.235 -33.453 1.00 28.57 ? 214 ALA A CB 1 ATOM 1400 N N . ASP A 1 188 ? -33.779 -33.976 -32.738 1.00 28.47 ? 215 ASP A N 1 ATOM 1401 C CA . ASP A 1 188 ? -35.149 -33.694 -33.158 1.00 28.76 ? 215 ASP A CA 1 ATOM 1402 C C . ASP A 1 188 ? -35.762 -32.638 -32.233 1.00 27.54 ? 215 ASP A C 1 ATOM 1403 O O . ASP A 1 188 ? -36.464 -31.719 -32.670 1.00 27.74 ? 215 ASP A O 1 ATOM 1404 C CB . ASP A 1 188 ? -36.000 -34.962 -33.117 1.00 29.49 ? 215 ASP A CB 1 ATOM 1405 C CG . ASP A 1 188 ? -35.585 -36.013 -34.175 1.00 33.81 ? 215 ASP A CG 1 ATOM 1406 O OD1 . ASP A 1 188 ? -34.762 -35.756 -35.091 1.00 35.74 ? 215 ASP A OD1 1 ATOM 1407 O OD2 . ASP A 1 188 ? -36.110 -37.131 -34.062 1.00 39.52 ? 215 ASP A OD2 1 ATOM 1408 N N . THR A 1 189 ? -35.486 -32.776 -30.949 1.00 25.65 ? 216 THR A N 1 ATOM 1409 C CA . THR A 1 189 ? -36.021 -31.876 -29.941 1.00 24.61 ? 216 THR A CA 1 ATOM 1410 C C . THR A 1 189 ? -35.489 -30.454 -30.150 1.00 25.66 ? 216 THR A C 1 ATOM 1411 O O . THR A 1 189 ? -36.261 -29.483 -30.185 1.00 25.90 ? 216 THR A O 1 ATOM 1412 C CB . THR A 1 189 ? -35.742 -32.441 -28.543 1.00 24.98 ? 216 THR A CB 1 ATOM 1413 O OG1 . THR A 1 189 ? -36.496 -33.667 -28.364 1.00 23.50 ? 216 THR A OG1 1 ATOM 1414 C CG2 . THR A 1 189 ? -36.150 -31.451 -27.479 1.00 26.00 ? 216 THR A CG2 1 ATOM 1415 N N . TYR A 1 190 ? -34.189 -30.341 -30.402 1.00 25.29 ? 217 TYR A N 1 ATOM 1416 C CA . TYR A 1 190 ? -33.588 -29.052 -30.699 1.00 25.96 ? 217 TYR A CA 1 ATOM 1417 C C . TYR A 1 190 ? -34.228 -28.473 -31.942 1.00 26.83 ? 217 TYR A C 1 ATOM 1418 O O . TYR A 1 190 ? -34.513 -27.266 -31.989 1.00 28.01 ? 217 TYR A O 1 ATOM 1419 C CB . TYR A 1 190 ? -32.065 -29.166 -30.914 1.00 25.39 ? 217 TYR A CB 1 ATOM 1420 C CG . TYR A 1 190 ? -31.181 -29.127 -29.668 1.00 25.83 ? 217 TYR A CG 1 ATOM 1421 C CD1 . TYR A 1 190 ? -31.621 -29.586 -28.426 1.00 25.02 ? 217 TYR A CD1 1 ATOM 1422 C CD2 . TYR A 1 190 ? -29.868 -28.649 -29.759 1.00 27.24 ? 217 TYR A CD2 1 ATOM 1423 C CE1 . TYR A 1 190 ? -30.787 -29.542 -27.310 1.00 25.96 ? 217 TYR A CE1 1 ATOM 1424 C CE2 . TYR A 1 190 ? -29.032 -28.599 -28.655 1.00 28.09 ? 217 TYR A CE2 1 ATOM 1425 C CZ . TYR A 1 190 ? -29.481 -29.057 -27.432 1.00 26.85 ? 217 TYR A CZ 1 ATOM 1426 O OH . TYR A 1 190 ? -28.611 -28.989 -26.357 1.00 25.37 ? 217 TYR A OH 1 ATOM 1427 N N . GLU A 1 191 ? -34.462 -29.319 -32.948 1.00 27.06 ? 218 GLU A N 1 ATOM 1428 C CA . GLU A 1 191 ? -35.126 -28.850 -34.163 1.00 29.16 ? 218 GLU A CA 1 ATOM 1429 C C . GLU A 1 191 ? -36.534 -28.303 -33.908 1.00 26.42 ? 218 GLU A C 1 ATOM 1430 O O . GLU A 1 191 ? -36.900 -27.251 -34.441 1.00 27.14 ? 218 GLU A O 1 ATOM 1431 C CB . GLU A 1 191 ? -35.153 -29.939 -35.243 1.00 32.35 ? 218 GLU A CB 1 ATOM 1432 C CG . GLU A 1 191 ? -35.753 -29.455 -36.568 1.00 37.70 ? 218 GLU A CG 1 ATOM 1433 C CD . GLU A 1 191 ? -35.254 -30.203 -37.808 1.00 44.45 ? 218 GLU A CD 1 ATOM 1434 O OE1 . GLU A 1 191 ? -34.585 -31.259 -37.687 1.00 47.79 ? 218 GLU A OE1 1 ATOM 1435 O OE2 . GLU A 1 191 ? -35.556 -29.729 -38.924 1.00 53.29 ? 218 GLU A OE2 1 ATOM 1436 N N . THR A 1 192 ? -37.339 -29.032 -33.144 1.00 23.84 ? 219 THR A N 1 ATOM 1437 C CA . THR A 1 192 ? -38.636 -28.528 -32.748 1.00 24.69 ? 219 THR A CA 1 ATOM 1438 C C . THR A 1 192 ? -38.504 -27.177 -32.001 1.00 26.04 ? 219 THR A C 1 ATOM 1439 O O . THR A 1 192 ? -39.264 -26.234 -32.252 1.00 26.28 ? 219 THR A O 1 ATOM 1440 C CB . THR A 1 192 ? -39.350 -29.567 -31.875 1.00 26.08 ? 219 THR A CB 1 ATOM 1441 O OG1 . THR A 1 192 ? -39.529 -30.747 -32.642 1.00 26.33 ? 219 THR A OG1 1 ATOM 1442 C CG2 . THR A 1 192 ? -40.698 -29.114 -31.413 1.00 25.78 ? 219 THR A CG2 1 ATOM 1443 N N . LEU A 1 193 ? -37.532 -27.065 -31.099 1.00 25.30 ? 220 LEU A N 1 ATOM 1444 C CA . LEU A 1 193 ? -37.366 -25.825 -30.367 1.00 25.67 ? 220 LEU A CA 1 ATOM 1445 C C . LEU A 1 193 ? -37.037 -24.655 -31.292 1.00 26.95 ? 220 LEU A C 1 ATOM 1446 O O . LEU A 1 193 ? -37.576 -23.533 -31.134 1.00 25.07 ? 220 LEU A O 1 ATOM 1447 C CB . LEU A 1 193 ? -36.317 -25.985 -29.282 1.00 25.27 ? 220 LEU A CB 1 ATOM 1448 C CG . LEU A 1 193 ? -36.801 -26.901 -28.146 1.00 24.52 ? 220 LEU A CG 1 ATOM 1449 C CD1 . LEU A 1 193 ? -35.676 -27.327 -27.254 1.00 24.19 ? 220 LEU A CD1 1 ATOM 1450 C CD2 . LEU A 1 193 ? -37.885 -26.214 -27.318 1.00 26.12 ? 220 LEU A CD2 1 ATOM 1451 N N . ALA A 1 194 ? -36.174 -24.926 -32.262 1.00 25.98 ? 221 ALA A N 1 ATOM 1452 C CA . ALA A 1 194 ? -35.739 -23.921 -33.202 1.00 26.88 ? 221 ALA A CA 1 ATOM 1453 C C . ALA A 1 194 ? -36.910 -23.398 -34.018 1.00 29.92 ? 221 ALA A C 1 ATOM 1454 O O . ALA A 1 194 ? -37.012 -22.193 -34.301 1.00 30.05 ? 221 ALA A O 1 ATOM 1455 C CB . ALA A 1 194 ? -34.692 -24.503 -34.128 1.00 27.21 ? 221 ALA A CB 1 ATOM 1456 N N . ILE A 1 195 ? -37.804 -24.303 -34.393 1.00 31.88 ? 222 ILE A N 1 ATOM 1457 C CA . ILE A 1 195 ? -38.901 -23.938 -35.276 1.00 33.70 ? 222 ILE A CA 1 ATOM 1458 C C . ILE A 1 195 ? -40.134 -23.449 -34.531 1.00 32.48 ? 222 ILE A C 1 ATOM 1459 O O . ILE A 1 195 ? -40.710 -22.470 -34.921 1.00 29.98 ? 222 ILE A O 1 ATOM 1460 C CB . ILE A 1 195 ? -39.280 -25.109 -36.195 1.00 37.53 ? 222 ILE A CB 1 ATOM 1461 C CG1 . ILE A 1 195 ? -38.086 -25.488 -37.073 1.00 41.71 ? 222 ILE A CG1 1 ATOM 1462 C CG2 . ILE A 1 195 ? -40.471 -24.722 -37.068 1.00 40.71 ? 222 ILE A CG2 1 ATOM 1463 C CD1 . ILE A 1 195 ? -38.183 -26.906 -37.609 1.00 46.98 ? 222 ILE A CD1 1 ATOM 1464 N N . GLU A 1 196 ? -40.552 -24.138 -33.471 1.00 34.43 ? 223 GLU A N 1 ATOM 1465 C CA . GLU A 1 196 ? -41.745 -23.737 -32.730 1.00 33.41 ? 223 GLU A CA 1 ATOM 1466 C C . GLU A 1 196 ? -41.438 -22.782 -31.572 1.00 33.99 ? 223 GLU A C 1 ATOM 1467 O O . GLU A 1 196 ? -42.351 -22.279 -30.932 1.00 36.31 ? 223 GLU A O 1 ATOM 1468 C CB . GLU A 1 196 ? -42.477 -24.982 -32.223 1.00 36.07 ? 223 GLU A CB 1 ATOM 1469 C CG . GLU A 1 196 ? -42.827 -25.980 -33.338 1.00 37.42 ? 223 GLU A CG 1 ATOM 1470 C CD . GLU A 1 196 ? -43.464 -27.274 -32.830 1.00 42.21 ? 223 GLU A CD 1 ATOM 1471 O OE1 . GLU A 1 196 ? -43.807 -27.349 -31.613 1.00 41.82 ? 223 GLU A OE1 1 ATOM 1472 O OE2 . GLU A 1 196 ? -43.623 -28.226 -33.654 1.00 43.50 ? 223 GLU A OE2 1 ATOM 1473 N N . GLY A 1 197 ? -40.169 -22.527 -31.281 1.00 30.57 ? 224 GLY A N 1 ATOM 1474 C CA . GLY A 1 197 ? -39.843 -21.679 -30.143 1.00 31.35 ? 224 GLY A CA 1 ATOM 1475 C C . GLY A 1 197 ? -39.958 -22.328 -28.758 1.00 31.63 ? 224 GLY A C 1 ATOM 1476 O O . GLY A 1 197 ? -40.273 -23.509 -28.608 1.00 30.23 ? 224 GLY A O 1 ATOM 1477 N N . ALA A 1 198 ? -39.732 -21.512 -27.738 1.00 31.99 ? 225 ALA A N 1 ATOM 1478 C CA . ALA A 1 198 ? -39.695 -21.954 -26.358 1.00 32.39 ? 225 ALA A CA 1 ATOM 1479 C C . ALA A 1 198 ? -41.018 -22.570 -25.887 1.00 32.70 ? 225 ALA A C 1 ATOM 1480 O O . ALA A 1 198 ? -41.046 -23.463 -25.019 1.00 27.73 ? 225 ALA A O 1 ATOM 1481 C CB . ALA A 1 198 ? -39.341 -20.759 -25.482 1.00 32.94 ? 225 ALA A CB 1 ATOM 1482 N N . GLN A 1 199 ? -42.110 -22.064 -26.446 1.00 29.91 ? 226 GLN A N 1 ATOM 1483 C CA . GLN A 1 199 ? -43.436 -22.529 -26.110 1.00 32.12 ? 226 GLN A CA 1 ATOM 1484 C C . GLN A 1 199 ? -43.601 -24.010 -26.373 1.00 28.65 ? 226 GLN A C 1 ATOM 1485 O O . GLN A 1 199 ? -44.430 -24.640 -25.750 1.00 27.63 ? 226 GLN A O 1 ATOM 1486 C CB . GLN A 1 199 ? -44.506 -21.769 -26.911 1.00 37.50 ? 226 GLN A CB 1 ATOM 1487 C CG . GLN A 1 199 ? -45.875 -21.734 -26.249 1.00 45.68 ? 226 GLN A CG 1 ATOM 1488 C CD . GLN A 1 199 ? -45.993 -20.710 -25.093 1.00 52.47 ? 226 GLN A CD 1 ATOM 1489 O OE1 . GLN A 1 199 ? -45.008 -20.076 -24.665 1.00 50.81 ? 226 GLN A OE1 1 ATOM 1490 N NE2 . GLN A 1 199 ? -47.222 -20.542 -24.588 1.00 56.56 ? 226 GLN A NE2 1 ATOM 1491 N N . ALA A 1 200 ? -42.864 -24.573 -27.321 1.00 26.51 ? 227 ALA A N 1 ATOM 1492 C CA . ALA A 1 200 ? -42.976 -26.014 -27.554 1.00 26.04 ? 227 ALA A CA 1 ATOM 1493 C C . ALA A 1 200 ? -42.654 -26.821 -26.291 1.00 25.32 ? 227 ALA A C 1 ATOM 1494 O O . ALA A 1 200 ? -43.221 -27.880 -26.060 1.00 25.04 ? 227 ALA A O 1 ATOM 1495 C CB . ALA A 1 200 ? -42.046 -26.434 -28.689 1.00 25.77 ? 227 ALA A CB 1 ATOM 1496 N N . PHE A 1 201 ? -41.704 -26.328 -25.505 1.00 25.04 ? 228 PHE A N 1 ATOM 1497 C CA . PHE A 1 201 ? -41.280 -26.983 -24.257 1.00 24.15 ? 228 PHE A CA 1 ATOM 1498 C C . PHE A 1 201 ? -42.316 -26.784 -23.149 1.00 23.82 ? 228 PHE A C 1 ATOM 1499 O O . PHE A 1 201 ? -42.692 -27.736 -22.470 1.00 23.99 ? 228 PHE A O 1 ATOM 1500 C CB . PHE A 1 201 ? -39.936 -26.386 -23.825 1.00 23.85 ? 228 PHE A CB 1 ATOM 1501 C CG . PHE A 1 201 ? -39.212 -27.157 -22.741 1.00 24.57 ? 228 PHE A CG 1 ATOM 1502 C CD1 . PHE A 1 201 ? -39.552 -27.002 -21.411 1.00 24.51 ? 228 PHE A CD1 1 ATOM 1503 C CD2 . PHE A 1 201 ? -38.132 -27.980 -23.059 1.00 24.83 ? 228 PHE A CD2 1 ATOM 1504 C CE1 . PHE A 1 201 ? -38.849 -27.677 -20.417 1.00 25.47 ? 228 PHE A CE1 1 ATOM 1505 C CE2 . PHE A 1 201 ? -37.440 -28.669 -22.060 1.00 25.33 ? 228 PHE A CE2 1 ATOM 1506 C CZ . PHE A 1 201 ? -37.800 -28.502 -20.744 1.00 24.76 ? 228 PHE A CZ 1 ATOM 1507 N N . TYR A 1 202 ? -42.792 -25.555 -22.993 1.00 23.58 ? 229 TYR A N 1 ATOM 1508 C CA . TYR A 1 202 ? -43.547 -25.177 -21.785 1.00 25.53 ? 229 TYR A CA 1 ATOM 1509 C C . TYR A 1 202 ? -45.044 -25.233 -21.927 1.00 26.42 ? 229 TYR A C 1 ATOM 1510 O O . TYR A 1 202 ? -45.744 -25.391 -20.923 1.00 25.44 ? 229 TYR A O 1 ATOM 1511 C CB . TYR A 1 202 ? -43.126 -23.770 -21.297 1.00 24.67 ? 229 TYR A CB 1 ATOM 1512 C CG . TYR A 1 202 ? -41.694 -23.783 -20.787 1.00 25.97 ? 229 TYR A CG 1 ATOM 1513 C CD1 . TYR A 1 202 ? -41.413 -24.169 -19.510 1.00 25.61 ? 229 TYR A CD1 1 ATOM 1514 C CD2 . TYR A 1 202 ? -40.612 -23.434 -21.620 1.00 26.35 ? 229 TYR A CD2 1 ATOM 1515 C CE1 . TYR A 1 202 ? -40.098 -24.225 -19.040 1.00 27.37 ? 229 TYR A CE1 1 ATOM 1516 C CE2 . TYR A 1 202 ? -39.284 -23.475 -21.163 1.00 25.54 ? 229 TYR A CE2 1 ATOM 1517 C CZ . TYR A 1 202 ? -39.029 -23.892 -19.867 1.00 26.57 ? 229 TYR A CZ 1 ATOM 1518 O OH . TYR A 1 202 ? -37.736 -23.956 -19.364 1.00 25.22 ? 229 TYR A OH 1 ATOM 1519 N N . ASN A 1 203 ? -45.537 -25.058 -23.151 1.00 28.17 ? 230 ASN A N 1 ATOM 1520 C CA . ASN A 1 203 ? -46.959 -25.052 -23.418 1.00 30.37 ? 230 ASN A CA 1 ATOM 1521 C C . ASN A 1 203 ? -47.233 -25.383 -24.882 1.00 28.26 ? 230 ASN A C 1 ATOM 1522 O O . ASN A 1 203 ? -47.781 -24.579 -25.623 1.00 25.45 ? 230 ASN A O 1 ATOM 1523 C CB . ASN A 1 203 ? -47.481 -23.655 -23.067 1.00 35.54 ? 230 ASN A CB 1 ATOM 1524 C CG . ASN A 1 203 ? -48.978 -23.523 -23.236 1.00 40.78 ? 230 ASN A CG 1 ATOM 1525 O OD1 . ASN A 1 203 ? -49.471 -22.547 -23.802 1.00 46.93 ? 230 ASN A OD1 1 ATOM 1526 N ND2 . ASN A 1 203 ? -49.709 -24.492 -22.745 1.00 47.72 ? 230 ASN A ND2 1 ATOM 1527 N N . GLY A 1 204 ? -46.777 -26.551 -25.311 1.00 30.03 ? 231 GLY A N 1 ATOM 1528 C CA . GLY A 1 204 ? -46.656 -26.851 -26.742 1.00 28.22 ? 231 GLY A CA 1 ATOM 1529 C C . GLY A 1 204 ? -46.411 -28.319 -26.997 1.00 28.43 ? 231 GLY A C 1 ATOM 1530 O O . GLY A 1 204 ? -46.749 -29.165 -26.176 1.00 27.77 ? 231 GLY A O 1 ATOM 1531 N N . SER A 1 205 ? -45.798 -28.627 -28.137 1.00 30.05 ? 232 SER A N 1 ATOM 1532 C CA . SER A 1 205 ? -45.757 -30.004 -28.648 1.00 28.05 ? 232 SER A CA 1 ATOM 1533 C C . SER A 1 205 ? -44.871 -30.960 -27.855 1.00 27.98 ? 232 SER A C 1 ATOM 1534 O O . SER A 1 205 ? -45.030 -32.169 -27.978 1.00 26.88 ? 232 SER A O 1 ATOM 1535 C CB . SER A 1 205 ? -45.305 -29.999 -30.090 1.00 30.09 ? 232 SER A CB 1 ATOM 1536 O OG . SER A 1 205 ? -43.961 -29.548 -30.194 1.00 29.93 ? 232 SER A OG 1 ATOM 1537 N N . LEU A 1 206 ? -43.954 -30.444 -27.031 1.00 26.06 ? 233 LEU A N 1 ATOM 1538 C CA . LEU A 1 206 ? -43.122 -31.319 -26.186 1.00 25.92 ? 233 LEU A CA 1 ATOM 1539 C C . LEU A 1 206 ? -43.688 -31.559 -24.786 1.00 24.89 ? 233 LEU A C 1 ATOM 1540 O O . LEU A 1 206 ? -43.250 -32.454 -24.079 1.00 27.39 ? 233 LEU A O 1 ATOM 1541 C CB . LEU A 1 206 ? -41.733 -30.706 -26.024 1.00 26.66 ? 233 LEU A CB 1 ATOM 1542 C CG . LEU A 1 206 ? -41.003 -30.364 -27.321 1.00 27.19 ? 233 LEU A CG 1 ATOM 1543 C CD1 . LEU A 1 206 ? -39.868 -29.400 -27.032 1.00 27.25 ? 233 LEU A CD1 1 ATOM 1544 C CD2 . LEU A 1 206 ? -40.483 -31.624 -27.993 1.00 27.72 ? 233 LEU A CD2 1 ATOM 1545 N N . THR A 1 207 ? -44.613 -30.715 -24.375 1.00 23.40 ? 234 THR A N 1 ATOM 1546 C CA . THR A 1 207 ? -44.963 -30.591 -22.993 1.00 25.46 ? 234 THR A CA 1 ATOM 1547 C C . THR A 1 207 ? -45.471 -31.859 -22.378 1.00 25.80 ? 234 THR A C 1 ATOM 1548 O O . THR A 1 207 ? -44.960 -32.276 -21.368 1.00 27.10 ? 234 THR A O 1 ATOM 1549 C CB . THR A 1 207 ? -46.000 -29.475 -22.799 1.00 24.75 ? 234 THR A CB 1 ATOM 1550 O OG1 . THR A 1 207 ? -45.449 -28.268 -23.309 1.00 24.81 ? 234 THR A OG1 1 ATOM 1551 C CG2 . THR A 1 207 ? -46.311 -29.296 -21.317 1.00 25.32 ? 234 THR A CG2 1 ATOM 1552 N N . ALA A 1 208 ? -46.444 -32.504 -23.016 1.00 27.44 ? 235 ALA A N 1 ATOM 1553 C CA . ALA A 1 208 ? -47.064 -33.716 -22.454 1.00 26.84 ? 235 ALA A CA 1 ATOM 1554 C C . ALA A 1 208 ? -46.101 -34.889 -22.342 1.00 26.04 ? 235 ALA A C 1 ATOM 1555 O O . ALA A 1 208 ? -46.145 -35.662 -21.369 1.00 27.12 ? 235 ALA A O 1 ATOM 1556 C CB . ALA A 1 208 ? -48.322 -34.108 -23.249 1.00 27.28 ? 235 ALA A CB 1 ATOM 1557 N N . GLN A 1 209 ? -45.229 -35.041 -23.322 1.00 25.37 ? 236 GLN A N 1 ATOM 1558 C CA . GLN A 1 209 ? -44.206 -36.072 -23.230 1.00 25.93 ? 236 GLN A CA 1 ATOM 1559 C C . GLN A 1 209 ? -43.228 -35.801 -22.048 1.00 26.58 ? 236 GLN A C 1 ATOM 1560 O O . GLN A 1 209 ? -42.799 -36.730 -21.352 1.00 24.00 ? 236 GLN A O 1 ATOM 1561 C CB . GLN A 1 209 ? -43.466 -36.149 -24.566 1.00 27.39 ? 236 GLN A CB 1 ATOM 1562 C CG . GLN A 1 209 ? -42.397 -37.225 -24.626 1.00 28.75 ? 236 GLN A CG 1 ATOM 1563 C CD . GLN A 1 209 ? -42.992 -38.596 -24.533 1.00 31.76 ? 236 GLN A CD 1 ATOM 1564 O OE1 . GLN A 1 209 ? -43.899 -38.927 -25.273 1.00 33.21 ? 236 GLN A OE1 1 ATOM 1565 N NE2 . GLN A 1 209 ? -42.488 -39.406 -23.621 1.00 36.47 ? 236 GLN A NE2 1 ATOM 1566 N N . ILE A 1 210 ? -42.865 -34.531 -21.827 1.00 26.50 ? 237 ILE A N 1 ATOM 1567 C CA . ILE A 1 210 ? -42.021 -34.186 -20.667 1.00 25.92 ? 237 ILE A CA 1 ATOM 1568 C C . ILE A 1 210 ? -42.680 -34.650 -19.369 1.00 25.17 ? 237 ILE A C 1 ATOM 1569 O O . ILE A 1 210 ? -42.059 -35.326 -18.560 1.00 23.54 ? 237 ILE A O 1 ATOM 1570 C CB . ILE A 1 210 ? -41.730 -32.684 -20.587 1.00 26.85 ? 237 ILE A CB 1 ATOM 1571 C CG1 . ILE A 1 210 ? -40.731 -32.296 -21.677 1.00 27.21 ? 237 ILE A CG1 1 ATOM 1572 C CG2 . ILE A 1 210 ? -41.140 -32.304 -19.234 1.00 28.70 ? 237 ILE A CG2 1 ATOM 1573 C CD1 . ILE A 1 210 ? -40.618 -30.811 -21.906 1.00 28.53 ? 237 ILE A CD1 1 ATOM 1574 N N . VAL A 1 211 ? -43.940 -34.290 -19.188 1.00 24.65 ? 238 VAL A N 1 ATOM 1575 C CA . VAL A 1 211 ? -44.645 -34.604 -17.966 1.00 26.38 ? 238 VAL A CA 1 ATOM 1576 C C . VAL A 1 211 ? -44.715 -36.124 -17.821 1.00 27.86 ? 238 VAL A C 1 ATOM 1577 O O . VAL A 1 211 ? -44.494 -36.680 -16.727 1.00 25.84 ? 238 VAL A O 1 ATOM 1578 C CB . VAL A 1 211 ? -46.067 -33.982 -17.970 1.00 26.68 ? 238 VAL A CB 1 ATOM 1579 C CG1 . VAL A 1 211 ? -46.934 -34.534 -16.833 1.00 27.27 ? 238 VAL A CG1 1 ATOM 1580 C CG2 . VAL A 1 211 ? -45.975 -32.473 -17.847 1.00 27.23 ? 238 VAL A CG2 1 ATOM 1581 N N . LYS A 1 212 ? -45.003 -36.795 -18.934 1.00 27.10 ? 239 LYS A N 1 ATOM 1582 C CA . LYS A 1 212 ? -45.127 -38.235 -18.910 1.00 30.24 ? 239 LYS A CA 1 ATOM 1583 C C . LYS A 1 212 ? -43.826 -38.918 -18.516 1.00 29.15 ? 239 LYS A C 1 ATOM 1584 O O . LYS A 1 212 ? -43.830 -39.876 -17.723 1.00 27.56 ? 239 LYS A O 1 ATOM 1585 C CB . LYS A 1 212 ? -45.592 -38.742 -20.265 1.00 32.61 ? 239 LYS A CB 1 ATOM 1586 C CG . LYS A 1 212 ? -45.573 -40.234 -20.380 1.00 36.07 ? 239 LYS A CG 1 ATOM 1587 C CD . LYS A 1 212 ? -46.268 -40.659 -21.658 1.00 42.19 ? 239 LYS A CD 1 ATOM 1588 C CE . LYS A 1 212 ? -46.083 -42.150 -21.883 1.00 46.32 ? 239 LYS A CE 1 ATOM 1589 N NZ . LYS A 1 212 ? -46.527 -42.494 -23.255 1.00 52.04 ? 239 LYS A NZ 1 ATOM 1590 N N . ASP A 1 213 ? -42.711 -38.445 -19.069 1.00 29.99 ? 240 ASP A N 1 ATOM 1591 C CA . ASP A 1 213 ? -41.397 -39.055 -18.754 1.00 31.76 ? 240 ASP A CA 1 ATOM 1592 C C . ASP A 1 213 ? -41.031 -38.885 -17.293 1.00 31.07 ? 240 ASP A C 1 ATOM 1593 O O . ASP A 1 213 ? -40.510 -39.819 -16.664 1.00 32.25 ? 240 ASP A O 1 ATOM 1594 C CB . ASP A 1 213 ? -40.293 -38.457 -19.626 1.00 33.78 ? 240 ASP A CB 1 ATOM 1595 C CG . ASP A 1 213 ? -40.424 -38.863 -21.083 1.00 35.69 ? 240 ASP A CG 1 ATOM 1596 O OD1 . ASP A 1 213 ? -40.747 -40.047 -21.330 1.00 38.41 ? 240 ASP A OD1 1 ATOM 1597 O OD2 . ASP A 1 213 ? -40.194 -38.005 -21.966 1.00 37.42 ? 240 ASP A OD2 1 ATOM 1598 N N . ILE A 1 214 ? -41.310 -37.697 -16.763 1.00 27.37 ? 241 ILE A N 1 ATOM 1599 C CA . ILE A 1 214 ? -40.974 -37.381 -15.383 1.00 28.43 ? 241 ILE A CA 1 ATOM 1600 C C . ILE A 1 214 ? -41.846 -38.215 -14.443 1.00 28.09 ? 241 ILE A C 1 ATOM 1601 O O . ILE A 1 214 ? -41.343 -38.810 -13.480 1.00 26.37 ? 241 ILE A O 1 ATOM 1602 C CB . ILE A 1 214 ? -41.133 -35.873 -15.089 1.00 27.35 ? 241 ILE A CB 1 ATOM 1603 C CG1 . ILE A 1 214 ? -40.074 -35.080 -15.865 1.00 28.63 ? 241 ILE A CG1 1 ATOM 1604 C CG2 . ILE A 1 214 ? -41.000 -35.602 -13.595 1.00 28.69 ? 241 ILE A CG2 1 ATOM 1605 C CD1 . ILE A 1 214 ? -40.253 -33.568 -15.805 1.00 29.93 ? 241 ILE A CD1 1 ATOM 1606 N N . GLN A 1 215 ? -43.139 -38.275 -14.727 1.00 28.73 ? 242 GLN A N 1 ATOM 1607 C CA . GLN A 1 215 ? -44.053 -39.070 -13.882 1.00 30.31 ? 242 GLN A CA 1 ATOM 1608 C C . GLN A 1 215 ? -43.796 -40.562 -13.956 1.00 28.67 ? 242 GLN A C 1 ATOM 1609 O O . GLN A 1 215 ? -43.846 -41.236 -12.932 1.00 29.64 ? 242 GLN A O 1 ATOM 1610 C CB . GLN A 1 215 ? -45.521 -38.745 -14.169 1.00 29.19 ? 242 GLN A CB 1 ATOM 1611 C CG . GLN A 1 215 ? -45.885 -37.376 -13.641 1.00 30.30 ? 242 GLN A CG 1 ATOM 1612 C CD . GLN A 1 215 ? -47.320 -37.016 -13.885 1.00 30.78 ? 242 GLN A CD 1 ATOM 1613 O OE1 . GLN A 1 215 ? -48.157 -37.884 -14.122 1.00 38.06 ? 242 GLN A OE1 1 ATOM 1614 N NE2 . GLN A 1 215 ? -47.618 -35.730 -13.846 1.00 29.98 ? 242 GLN A NE2 1 ATOM 1615 N N . ALA A 1 216 ? -43.463 -41.091 -15.129 1.00 31.42 ? 243 ALA A N 1 ATOM 1616 C CA . ALA A 1 216 ? -43.209 -42.536 -15.240 1.00 32.05 ? 243 ALA A CA 1 ATOM 1617 C C . ALA A 1 216 ? -42.058 -42.939 -14.342 1.00 33.36 ? 243 ALA A C 1 ATOM 1618 O O . ALA A 1 216 ? -42.018 -44.056 -13.819 1.00 33.47 ? 243 ALA A O 1 ATOM 1619 C CB . ALA A 1 216 ? -42.913 -42.940 -16.679 1.00 32.30 ? 243 ALA A CB 1 ATOM 1620 N N . ALA A 1 217 ? -41.103 -42.026 -14.163 1.00 33.10 ? 244 ALA A N 1 ATOM 1621 C CA . ALA A 1 217 ? -39.960 -42.296 -13.298 1.00 29.95 ? 244 ALA A CA 1 ATOM 1622 C C . ALA A 1 217 ? -40.232 -41.945 -11.838 1.00 31.20 ? 244 ALA A C 1 ATOM 1623 O O . ALA A 1 217 ? -39.307 -41.925 -11.027 1.00 30.88 ? 244 ALA A O 1 ATOM 1624 C CB . ALA A 1 217 ? -38.752 -41.535 -13.813 1.00 31.50 ? 244 ALA A CB 1 ATOM 1625 N N . GLY A 1 218 ? -41.490 -41.644 -11.502 1.00 31.66 ? 245 GLY A N 1 ATOM 1626 C CA . GLY A 1 218 ? -41.906 -41.428 -10.106 1.00 30.53 ? 245 GLY A CA 1 ATOM 1627 C C . GLY A 1 218 ? -42.017 -39.972 -9.679 1.00 30.40 ? 245 GLY A C 1 ATOM 1628 O O . GLY A 1 218 ? -42.144 -39.695 -8.497 1.00 29.69 ? 245 GLY A O 1 ATOM 1629 N N . GLY A 1 219 ? -41.983 -39.050 -10.642 1.00 28.00 ? 246 GLY A N 1 ATOM 1630 C CA . GLY A 1 219 ? -41.990 -37.634 -10.374 1.00 27.26 ? 246 GLY A CA 1 ATOM 1631 C C . GLY A 1 219 ? -43.363 -37.035 -10.258 1.00 27.39 ? 246 GLY A C 1 ATOM 1632 O O . GLY A 1 219 ? -44.376 -37.721 -10.399 1.00 27.14 ? 246 GLY A O 1 ATOM 1633 N N . ILE A 1 220 ? -43.401 -35.740 -9.979 1.00 27.32 ? 247 ILE A N 1 ATOM 1634 C CA . ILE A 1 220 ? -44.673 -35.061 -9.696 1.00 25.86 ? 247 ILE A CA 1 ATOM 1635 C C . ILE A 1 220 ? -44.873 -33.766 -10.461 1.00 26.08 ? 247 ILE A C 1 ATOM 1636 O O . ILE A 1 220 ? -45.848 -33.035 -10.220 1.00 27.35 ? 247 ILE A O 1 ATOM 1637 C CB . ILE A 1 220 ? -44.826 -34.797 -8.195 1.00 25.84 ? 247 ILE A CB 1 ATOM 1638 C CG1 . ILE A 1 220 ? -43.673 -33.938 -7.672 1.00 26.48 ? 247 ILE A CG1 1 ATOM 1639 C CG2 . ILE A 1 220 ? -44.894 -36.125 -7.438 1.00 25.86 ? 247 ILE A CG2 1 ATOM 1640 C CD1 . ILE A 1 220 ? -43.878 -33.478 -6.242 1.00 27.45 ? 247 ILE A CD1 1 ATOM 1641 N N . VAL A 1 221 ? -43.977 -33.493 -11.407 1.00 25.88 ? 248 VAL A N 1 ATOM 1642 C CA . VAL A 1 221 ? -44.120 -32.335 -12.289 1.00 25.10 ? 248 VAL A CA 1 ATOM 1643 C C . VAL A 1 221 ? -45.347 -32.524 -13.159 1.00 26.93 ? 248 VAL A C 1 ATOM 1644 O O . VAL A 1 221 ? -45.568 -33.610 -13.664 1.00 26.35 ? 248 VAL A O 1 ATOM 1645 C CB . VAL A 1 221 ? -42.892 -32.202 -13.197 1.00 25.06 ? 248 VAL A CB 1 ATOM 1646 C CG1 . VAL A 1 221 ? -43.106 -31.151 -14.285 1.00 25.85 ? 248 VAL A CG1 1 ATOM 1647 C CG2 . VAL A 1 221 ? -41.657 -31.876 -12.365 1.00 25.87 ? 248 VAL A CG2 1 ATOM 1648 N N . THR A 1 222 ? -46.132 -31.458 -13.344 1.00 29.42 ? 249 THR A N 1 ATOM 1649 C CA . THR A 1 222 ? -47.361 -31.510 -14.136 1.00 27.85 ? 249 THR A CA 1 ATOM 1650 C C . THR A 1 222 ? -47.285 -30.503 -15.261 1.00 28.32 ? 249 THR A C 1 ATOM 1651 O O . THR A 1 222 ? -46.395 -29.642 -15.276 1.00 27.88 ? 249 THR A O 1 ATOM 1652 C CB . THR A 1 222 ? -48.579 -31.123 -13.276 1.00 28.66 ? 249 THR A CB 1 ATOM 1653 O OG1 . THR A 1 222 ? -48.352 -29.830 -12.744 1.00 32.15 ? 249 THR A OG1 1 ATOM 1654 C CG2 . THR A 1 222 ? -48.768 -32.069 -12.127 1.00 28.46 ? 249 THR A CG2 1 ATOM 1655 N N . ALA A 1 223 ? -48.237 -30.574 -16.192 1.00 26.81 ? 250 ALA A N 1 ATOM 1656 C CA . ALA A 1 223 ? -48.288 -29.601 -17.287 1.00 28.09 ? 250 ALA A CA 1 ATOM 1657 C C . ALA A 1 223 ? -48.364 -28.180 -16.763 1.00 27.08 ? 250 ALA A C 1 ATOM 1658 O O . ALA A 1 223 ? -47.709 -27.275 -17.271 1.00 25.31 ? 250 ALA A O 1 ATOM 1659 C CB . ALA A 1 223 ? -49.469 -29.889 -18.217 1.00 27.75 ? 250 ALA A CB 1 ATOM 1660 N N . GLU A 1 224 ? -49.178 -27.997 -15.738 1.00 28.38 ? 251 GLU A N 1 ATOM 1661 C CA . GLU A 1 224 ? -49.360 -26.695 -15.081 1.00 31.19 ? 251 GLU A CA 1 ATOM 1662 C C . GLU A 1 224 ? -48.010 -26.084 -14.623 1.00 26.61 ? 251 GLU A C 1 ATOM 1663 O O . GLU A 1 224 ? -47.785 -24.891 -14.754 1.00 24.24 ? 251 GLU A O 1 ATOM 1664 C CB . GLU A 1 224 ? -50.289 -26.893 -13.860 1.00 40.37 ? 251 GLU A CB 1 ATOM 1665 C CG . GLU A 1 224 ? -51.239 -25.749 -13.511 1.00 53.96 ? 251 GLU A CG 1 ATOM 1666 C CD . GLU A 1 224 ? -51.780 -25.806 -12.056 1.00 61.78 ? 251 GLU A CD 1 ATOM 1667 O OE1 . GLU A 1 224 ? -52.090 -26.909 -11.539 1.00 62.81 ? 251 GLU A OE1 1 ATOM 1668 O OE2 . GLU A 1 224 ? -51.905 -24.735 -11.417 1.00 66.71 ? 251 GLU A OE2 1 ATOM 1669 N N . ASP A 1 225 ? -47.133 -26.905 -14.049 1.00 26.19 ? 252 ASP A N 1 ATOM 1670 C CA . ASP A 1 225 ? -45.798 -26.428 -13.617 1.00 27.26 ? 252 ASP A CA 1 ATOM 1671 C C . ASP A 1 225 ? -45.025 -25.834 -14.801 1.00 26.53 ? 252 ASP A C 1 ATOM 1672 O O . ASP A 1 225 ? -44.462 -24.737 -14.700 1.00 23.85 ? 252 ASP A O 1 ATOM 1673 C CB . ASP A 1 225 ? -44.964 -27.551 -12.992 1.00 26.38 ? 252 ASP A CB 1 ATOM 1674 C CG . ASP A 1 225 ? -45.508 -28.027 -11.652 1.00 27.81 ? 252 ASP A CG 1 ATOM 1675 O OD1 . ASP A 1 225 ? -45.706 -27.171 -10.752 1.00 28.30 ? 252 ASP A OD1 1 ATOM 1676 O OD2 . ASP A 1 225 ? -45.724 -29.263 -11.484 1.00 29.46 ? 252 ASP A OD2 1 ATOM 1677 N N . LEU A 1 226 ? -45.015 -26.563 -15.918 1.00 25.62 ? 253 LEU A N 1 ATOM 1678 C CA . LEU A 1 226 ? -44.329 -26.113 -17.131 1.00 26.46 ? 253 LEU A CA 1 ATOM 1679 C C . LEU A 1 226 ? -44.990 -24.837 -17.682 1.00 26.75 ? 253 LEU A C 1 ATOM 1680 O O . LEU A 1 226 ? -44.298 -23.834 -17.939 1.00 25.88 ? 253 LEU A O 1 ATOM 1681 C CB . LEU A 1 226 ? -44.314 -27.246 -18.184 1.00 27.28 ? 253 LEU A CB 1 ATOM 1682 C CG . LEU A 1 226 ? -43.405 -28.410 -17.816 1.00 28.47 ? 253 LEU A CG 1 ATOM 1683 C CD1 . LEU A 1 226 ? -43.698 -29.671 -18.608 1.00 30.25 ? 253 LEU A CD1 1 ATOM 1684 C CD2 . LEU A 1 226 ? -41.959 -28.000 -18.036 1.00 29.08 ? 253 LEU A CD2 1 ATOM 1685 N N . ASN A 1 227 ? -46.326 -24.859 -17.826 1.00 26.79 ? 254 ASN A N 1 ATOM 1686 C CA . ASN A 1 227 ? -47.047 -23.684 -18.311 1.00 27.51 ? 254 ASN A CA 1 ATOM 1687 C C . ASN A 1 227 ? -46.689 -22.458 -17.451 1.00 27.41 ? 254 ASN A C 1 ATOM 1688 O O . ASN A 1 227 ? -46.559 -21.344 -17.976 1.00 25.10 ? 254 ASN A O 1 ATOM 1689 C CB . ASN A 1 227 ? -48.584 -23.841 -18.283 1.00 28.70 ? 254 ASN A CB 1 ATOM 1690 C CG . ASN A 1 227 ? -49.118 -25.054 -19.087 1.00 33.09 ? 254 ASN A CG 1 ATOM 1691 O OD1 . ASN A 1 227 ? -50.290 -25.439 -18.919 1.00 38.54 ? 254 ASN A OD1 1 ATOM 1692 N ND2 . ASN A 1 227 ? -48.282 -25.666 -19.935 1.00 33.15 ? 254 ASN A ND2 1 ATOM 1693 N N . ASN A 1 228 ? -46.548 -22.649 -16.142 1.00 26.19 ? 255 ASN A N 1 ATOM 1694 C CA . ASN A 1 228 ? -46.358 -21.498 -15.252 1.00 29.00 ? 255 ASN A CA 1 ATOM 1695 C C . ASN A 1 228 ? -44.920 -21.034 -15.057 1.00 27.46 ? 255 ASN A C 1 ATOM 1696 O O . ASN A 1 228 ? -44.723 -19.989 -14.441 1.00 27.92 ? 255 ASN A O 1 ATOM 1697 C CB . ASN A 1 228 ? -46.997 -21.750 -13.873 1.00 29.38 ? 255 ASN A CB 1 ATOM 1698 C CG . ASN A 1 228 ? -48.524 -21.845 -13.927 1.00 32.28 ? 255 ASN A CG 1 ATOM 1699 O OD1 . ASN A 1 228 ? -49.175 -21.334 -14.828 1.00 35.08 ? 255 ASN A OD1 1 ATOM 1700 N ND2 . ASN A 1 228 ? -49.093 -22.505 -12.942 1.00 33.81 ? 255 ASN A ND2 1 ATOM 1701 N N . TYR A 1 229 ? -43.922 -21.786 -15.542 1.00 26.10 ? 256 TYR A N 1 ATOM 1702 C CA . TYR A 1 229 ? -42.527 -21.414 -15.272 1.00 25.02 ? 256 TYR A CA 1 ATOM 1703 C C . TYR A 1 229 ? -42.240 -20.054 -15.912 1.00 25.64 ? 256 TYR A C 1 ATOM 1704 O O . TYR A 1 229 ? -42.686 -19.802 -17.015 1.00 26.35 ? 256 TYR A O 1 ATOM 1705 C CB . TYR A 1 229 ? -41.504 -22.455 -15.789 1.00 24.60 ? 256 TYR A CB 1 ATOM 1706 C CG . TYR A 1 229 ? -40.118 -22.040 -15.401 1.00 23.61 ? 256 TYR A CG 1 ATOM 1707 C CD1 . TYR A 1 229 ? -39.382 -21.169 -16.193 1.00 23.54 ? 256 TYR A CD1 1 ATOM 1708 C CD2 . TYR A 1 229 ? -39.569 -22.431 -14.173 1.00 23.40 ? 256 TYR A CD2 1 ATOM 1709 C CE1 . TYR A 1 229 ? -38.139 -20.707 -15.786 1.00 23.47 ? 256 TYR A CE1 1 ATOM 1710 C CE2 . TYR A 1 229 ? -38.322 -21.997 -13.787 1.00 21.83 ? 256 TYR A CE2 1 ATOM 1711 C CZ . TYR A 1 229 ? -37.612 -21.143 -14.594 1.00 22.42 ? 256 TYR A CZ 1 ATOM 1712 O OH . TYR A 1 229 ? -36.376 -20.689 -14.182 1.00 23.39 ? 256 TYR A OH 1 ATOM 1713 N N . ARG A 1 230 ? -41.513 -19.179 -15.222 1.00 25.65 ? 257 ARG A N 1 ATOM 1714 C CA . ARG A 1 230 ? -41.096 -17.905 -15.801 1.00 27.89 ? 257 ARG A CA 1 ATOM 1715 C C . ARG A 1 230 ? -39.652 -17.606 -15.452 1.00 27.84 ? 257 ARG A C 1 ATOM 1716 O O . ARG A 1 230 ? -39.268 -17.696 -14.275 1.00 27.45 ? 257 ARG A O 1 ATOM 1717 C CB . ARG A 1 230 ? -41.931 -16.731 -15.249 1.00 30.68 ? 257 ARG A CB 1 ATOM 1718 C CG . ARG A 1 230 ? -43.382 -16.684 -15.686 1.00 33.54 ? 257 ARG A CG 1 ATOM 1719 C CD . ARG A 1 230 ? -43.554 -16.490 -17.188 1.00 36.95 ? 257 ARG A CD 1 ATOM 1720 N NE . ARG A 1 230 ? -44.983 -16.451 -17.528 1.00 42.75 ? 257 ARG A NE 1 ATOM 1721 C CZ . ARG A 1 230 ? -45.773 -17.518 -17.691 1.00 43.54 ? 257 ARG A CZ 1 ATOM 1722 N NH1 . ARG A 1 230 ? -45.300 -18.755 -17.584 1.00 45.08 ? 257 ARG A NH1 1 ATOM 1723 N NH2 . ARG A 1 230 ? -47.055 -17.343 -17.969 1.00 44.96 ? 257 ARG A NH2 1 ATOM 1724 N N . ALA A 1 231 ? -38.871 -17.222 -16.462 1.00 26.34 ? 258 ALA A N 1 ATOM 1725 C CA . ALA A 1 231 ? -37.551 -16.692 -16.243 1.00 26.02 ? 258 ALA A CA 1 ATOM 1726 C C . ALA A 1 231 ? -37.736 -15.285 -15.695 1.00 27.29 ? 258 ALA A C 1 ATOM 1727 O O . ALA A 1 231 ? -38.677 -14.619 -16.042 1.00 30.50 ? 258 ALA A O 1 ATOM 1728 C CB . ALA A 1 231 ? -36.777 -16.665 -17.542 1.00 26.30 ? 258 ALA A CB 1 ATOM 1729 N N . GLU A 1 232 ? -36.829 -14.838 -14.851 1.00 27.12 ? 259 GLU A N 1 ATOM 1730 C CA . GLU A 1 232 ? -36.942 -13.545 -14.215 1.00 28.39 ? 259 GLU A CA 1 ATOM 1731 C C . GLU A 1 232 ? -35.768 -12.604 -14.547 1.00 26.24 ? 259 GLU A C 1 ATOM 1732 O O . GLU A 1 232 ? -34.609 -12.943 -14.376 1.00 23.80 ? 259 GLU A O 1 ATOM 1733 C CB . GLU A 1 232 ? -37.044 -13.728 -12.697 1.00 31.93 ? 259 GLU A CB 1 ATOM 1734 C CG . GLU A 1 232 ? -37.131 -12.418 -11.899 1.00 36.79 ? 259 GLU A CG 1 ATOM 1735 C CD . GLU A 1 232 ? -36.795 -12.562 -10.404 1.00 41.84 ? 259 GLU A CD 1 ATOM 1736 O OE1 . GLU A 1 232 ? -36.182 -13.581 -9.966 1.00 38.83 ? 259 GLU A OE1 1 ATOM 1737 O OE2 . GLU A 1 232 ? -37.157 -11.616 -9.667 1.00 45.01 ? 259 GLU A OE2 1 ATOM 1738 N N . LEU A 1 233 ? -36.106 -11.407 -15.004 1.00 26.72 ? 260 LEU A N 1 ATOM 1739 C CA . LEU A 1 233 ? -35.144 -10.338 -15.209 1.00 28.11 ? 260 LEU A CA 1 ATOM 1740 C C . LEU A 1 233 ? -34.889 -9.662 -13.871 1.00 27.43 ? 260 LEU A C 1 ATOM 1741 O O . LEU A 1 233 ? -35.806 -9.266 -13.208 1.00 28.76 ? 260 LEU A O 1 ATOM 1742 C CB . LEU A 1 233 ? -35.677 -9.317 -16.221 1.00 29.02 ? 260 LEU A CB 1 ATOM 1743 C CG . LEU A 1 233 ? -34.846 -8.020 -16.384 1.00 31.42 ? 260 LEU A CG 1 ATOM 1744 C CD1 . LEU A 1 233 ? -33.473 -8.326 -16.939 1.00 31.20 ? 260 LEU A CD1 1 ATOM 1745 C CD2 . LEU A 1 233 ? -35.573 -7.001 -17.262 1.00 32.15 ? 260 LEU A CD2 1 ATOM 1746 N N . ILE A 1 234 ? -33.632 -9.556 -13.480 1.00 28.33 ? 261 ILE A N 1 ATOM 1747 C CA . ILE A 1 234 ? -33.218 -8.799 -12.298 1.00 28.82 ? 261 ILE A CA 1 ATOM 1748 C C . ILE A 1 234 ? -32.349 -7.629 -12.789 1.00 29.08 ? 261 ILE A C 1 ATOM 1749 O O . ILE A 1 234 ? -31.218 -7.829 -13.231 1.00 25.06 ? 261 ILE A O 1 ATOM 1750 C CB . ILE A 1 234 ? -32.413 -9.708 -11.336 1.00 32.15 ? 261 ILE A CB 1 ATOM 1751 C CG1 . ILE A 1 234 ? -33.306 -10.854 -10.825 1.00 34.20 ? 261 ILE A CG1 1 ATOM 1752 C CG2 . ILE A 1 234 ? -31.841 -8.904 -10.163 1.00 32.14 ? 261 ILE A CG2 1 ATOM 1753 C CD1 . ILE A 1 234 ? -32.553 -12.036 -10.267 1.00 33.98 ? 261 ILE A CD1 1 ATOM 1754 N N . GLU A 1 235 ? -32.882 -6.435 -12.716 1.00 33.29 ? 262 GLU A N 1 ATOM 1755 C CA . GLU A 1 235 ? -32.207 -5.261 -13.193 1.00 37.38 ? 262 GLU A CA 1 ATOM 1756 C C . GLU A 1 235 ? -31.062 -4.782 -12.332 1.00 34.80 ? 262 GLU A C 1 ATOM 1757 O O . GLU A 1 235 ? -30.204 -4.125 -12.793 1.00 35.88 ? 262 GLU A O 1 ATOM 1758 C CB . GLU A 1 235 ? -33.220 -4.167 -13.350 1.00 43.70 ? 262 GLU A CB 1 ATOM 1759 C CG . GLU A 1 235 ? -34.192 -4.471 -14.440 1.00 52.76 ? 262 GLU A CG 1 ATOM 1760 C CD . GLU A 1 235 ? -35.268 -3.440 -14.588 1.00 61.48 ? 262 GLU A CD 1 ATOM 1761 O OE1 . GLU A 1 235 ? -35.387 -2.565 -13.727 1.00 68.51 ? 262 GLU A OE1 1 ATOM 1762 O OE2 . GLU A 1 235 ? -35.992 -3.518 -15.575 1.00 60.52 ? 262 GLU A OE2 1 ATOM 1763 N N . HIS A 1 236 ? -31.085 -5.128 -11.071 1.00 36.19 ? 263 HIS A N 1 ATOM 1764 C CA . HIS A 1 236 ? -30.053 -4.717 -10.109 1.00 36.46 ? 263 HIS A CA 1 ATOM 1765 C C . HIS A 1 236 ? -29.405 -5.937 -9.477 1.00 33.36 ? 263 HIS A C 1 ATOM 1766 O O . HIS A 1 236 ? -29.766 -6.378 -8.402 1.00 33.34 ? 263 HIS A O 1 ATOM 1767 C CB . HIS A 1 236 ? -30.659 -3.786 -9.060 1.00 40.40 ? 263 HIS A CB 1 ATOM 1768 C CG . HIS A 1 236 ? -31.279 -2.569 -9.663 1.00 47.28 ? 263 HIS A CG 1 ATOM 1769 N ND1 . HIS A 1 236 ? -30.537 -1.613 -10.328 1.00 54.10 ? 263 HIS A ND1 1 ATOM 1770 C CD2 . HIS A 1 236 ? -32.572 -2.185 -9.772 1.00 52.27 ? 263 HIS A CD2 1 ATOM 1771 C CE1 . HIS A 1 236 ? -31.345 -0.675 -10.793 1.00 53.99 ? 263 HIS A CE1 1 ATOM 1772 N NE2 . HIS A 1 236 ? -32.585 -1.001 -10.473 1.00 56.94 ? 263 HIS A NE2 1 ATOM 1773 N N . PRO A 1 237 ? -28.456 -6.517 -10.181 1.00 32.15 ? 264 PRO A N 1 ATOM 1774 C CA . PRO A 1 237 ? -27.709 -7.585 -9.575 1.00 32.91 ? 264 PRO A CA 1 ATOM 1775 C C . PRO A 1 237 ? -26.877 -7.088 -8.394 1.00 33.31 ? 264 PRO A C 1 ATOM 1776 O O . PRO A 1 237 ? -26.745 -5.889 -8.183 1.00 32.19 ? 264 PRO A O 1 ATOM 1777 C CB . PRO A 1 237 ? -26.769 -8.052 -10.682 1.00 34.08 ? 264 PRO A CB 1 ATOM 1778 C CG . PRO A 1 237 ? -26.885 -7.085 -11.800 1.00 34.35 ? 264 PRO A CG 1 ATOM 1779 C CD . PRO A 1 237 ? -27.942 -6.093 -11.490 1.00 33.18 ? 264 PRO A CD 1 ATOM 1780 N N . LEU A 1 238 ? -26.302 -8.032 -7.669 1.00 32.10 ? 265 LEU A N 1 ATOM 1781 C CA . LEU A 1 238 ? -25.361 -7.729 -6.622 1.00 32.98 ? 265 LEU A CA 1 ATOM 1782 C C . LEU A 1 238 ? -24.138 -7.102 -7.252 1.00 33.84 ? 265 LEU A C 1 ATOM 1783 O O . LEU A 1 238 ? -23.725 -7.471 -8.356 1.00 32.22 ? 265 LEU A O 1 ATOM 1784 C CB . LEU A 1 238 ? -24.971 -9.012 -5.880 1.00 34.28 ? 265 LEU A CB 1 ATOM 1785 C CG . LEU A 1 238 ? -24.741 -8.867 -4.396 1.00 37.53 ? 265 LEU A CG 1 ATOM 1786 C CD1 . LEU A 1 238 ? -26.005 -8.293 -3.755 1.00 40.67 ? 265 LEU A CD1 1 ATOM 1787 C CD2 . LEU A 1 238 ? -24.348 -10.202 -3.769 1.00 36.42 ? 265 LEU A CD2 1 ATOM 1788 N N . ASN A 1 239 ? -23.583 -6.114 -6.580 1.00 33.97 ? 266 ASN A N 1 ATOM 1789 C CA . ASN A 1 239 ? -22.262 -5.663 -6.927 1.00 38.16 ? 266 ASN A CA 1 ATOM 1790 C C . ASN A 1 239 ? -21.395 -5.405 -5.688 1.00 40.27 ? 266 ASN A C 1 ATOM 1791 O O . ASN A 1 239 ? -21.900 -5.174 -4.558 1.00 43.86 ? 266 ASN A O 1 ATOM 1792 C CB . ASN A 1 239 ? -22.353 -4.425 -7.756 1.00 39.17 ? 266 ASN A CB 1 ATOM 1793 C CG . ASN A 1 239 ? -22.654 -3.233 -6.920 1.00 44.49 ? 266 ASN A CG 1 ATOM 1794 O OD1 . ASN A 1 239 ? -21.857 -2.864 -6.055 1.00 36.85 ? 266 ASN A OD1 1 ATOM 1795 N ND2 . ASN A 1 239 ? -23.820 -2.626 -7.153 1.00 49.26 ? 266 ASN A ND2 1 ATOM 1796 N N . ILE A 1 240 ? -20.093 -5.496 -5.889 1.00 34.58 ? 267 ILE A N 1 ATOM 1797 C CA . ILE A 1 240 ? -19.168 -4.912 -4.955 1.00 34.26 ? 267 ILE A CA 1 ATOM 1798 C C . ILE A 1 240 ? -18.138 -4.129 -5.709 1.00 31.99 ? 267 ILE A C 1 ATOM 1799 O O . ILE A 1 240 ? -17.881 -4.347 -6.885 1.00 29.61 ? 267 ILE A O 1 ATOM 1800 C CB . ILE A 1 240 ? -18.457 -5.924 -4.017 1.00 36.51 ? 267 ILE A CB 1 ATOM 1801 C CG1 . ILE A 1 240 ? -17.679 -6.964 -4.799 1.00 37.41 ? 267 ILE A CG1 1 ATOM 1802 C CG2 . ILE A 1 240 ? -19.476 -6.588 -3.096 1.00 40.45 ? 267 ILE A CG2 1 ATOM 1803 C CD1 . ILE A 1 240 ? -16.734 -7.764 -3.928 1.00 41.00 ? 267 ILE A CD1 1 ATOM 1804 N N . SER A 1 241 ? -17.552 -3.217 -4.970 1.00 32.28 ? 268 SER A N 1 ATOM 1805 C CA . SER A 1 241 ? -16.531 -2.363 -5.439 1.00 33.92 ? 268 SER A CA 1 ATOM 1806 C C . SER A 1 241 ? -15.223 -3.030 -5.034 1.00 33.17 ? 268 SER A C 1 ATOM 1807 O O . SER A 1 241 ? -15.041 -3.399 -3.887 1.00 35.07 ? 268 SER A O 1 ATOM 1808 C CB . SER A 1 241 ? -16.745 -1.004 -4.778 1.00 36.24 ? 268 SER A CB 1 ATOM 1809 O OG . SER A 1 241 ? -15.567 -0.260 -4.724 1.00 42.86 ? 268 SER A OG 1 ATOM 1810 N N . LEU A 1 242 ? -14.340 -3.224 -6.001 1.00 32.64 ? 269 LEU A N 1 ATOM 1811 C CA . LEU A 1 242 ? -12.995 -3.678 -5.764 1.00 33.85 ? 269 LEU A CA 1 ATOM 1812 C C . LEU A 1 242 ? -12.031 -2.721 -6.456 1.00 33.89 ? 269 LEU A C 1 ATOM 1813 O O . LEU A 1 242 ? -11.882 -2.771 -7.674 1.00 32.56 ? 269 LEU A O 1 ATOM 1814 C CB . LEU A 1 242 ? -12.809 -5.077 -6.351 1.00 38.51 ? 269 LEU A CB 1 ATOM 1815 C CG . LEU A 1 242 ? -12.584 -6.249 -5.411 1.00 37.60 ? 269 LEU A CG 1 ATOM 1816 C CD1 . LEU A 1 242 ? -13.434 -6.139 -4.170 1.00 39.78 ? 269 LEU A CD1 1 ATOM 1817 C CD2 . LEU A 1 242 ? -12.868 -7.531 -6.176 1.00 37.64 ? 269 LEU A CD2 1 ATOM 1818 N N . GLY A 1 243 ? -11.378 -1.858 -5.675 1.00 32.56 ? 270 GLY A N 1 ATOM 1819 C CA . GLY A 1 243 ? -10.496 -0.845 -6.230 1.00 33.59 ? 270 GLY A CA 1 ATOM 1820 C C . GLY A 1 243 ? -11.286 0.100 -7.120 1.00 32.62 ? 270 GLY A C 1 ATOM 1821 O O . GLY A 1 243 ? -12.309 0.646 -6.719 1.00 35.35 ? 270 GLY A O 1 ATOM 1822 N N . ASP A 1 244 ? -10.826 0.238 -8.347 1.00 31.10 ? 271 ASP A N 1 ATOM 1823 C CA . ASP A 1 244 ? -11.523 0.997 -9.365 1.00 33.96 ? 271 ASP A CA 1 ATOM 1824 C C . ASP A 1 244 ? -12.511 0.152 -10.197 1.00 34.91 ? 271 ASP A C 1 ATOM 1825 O O . ASP A 1 244 ? -12.918 0.569 -11.288 1.00 34.03 ? 271 ASP A O 1 ATOM 1826 C CB . ASP A 1 244 ? -10.484 1.617 -10.299 1.00 34.85 ? 271 ASP A CB 1 ATOM 1827 C CG . ASP A 1 244 ? -9.625 2.653 -9.599 1.00 38.89 ? 271 ASP A CG 1 ATOM 1828 O OD1 . ASP A 1 244 ? -10.002 3.110 -8.489 1.00 35.54 ? 271 ASP A OD1 1 ATOM 1829 O OD2 . ASP A 1 244 ? -8.576 3.020 -10.168 1.00 47.04 ? 271 ASP A OD2 1 ATOM 1830 N N . ALA A 1 245 ? -12.888 -1.027 -9.706 1.00 33.46 ? 272 ALA A N 1 ATOM 1831 C CA . ALA A 1 245 ? -13.777 -1.894 -10.475 1.00 34.39 ? 272 ALA A CA 1 ATOM 1832 C C . ALA A 1 245 ? -15.041 -2.151 -9.717 1.00 31.56 ? 272 ALA A C 1 ATOM 1833 O O . ALA A 1 245 ? -15.103 -1.978 -8.520 1.00 32.54 ? 272 ALA A O 1 ATOM 1834 C CB . ALA A 1 245 ? -13.101 -3.219 -10.802 1.00 35.20 ? 272 ALA A CB 1 ATOM 1835 N N . VAL A 1 246 ? -16.052 -2.587 -10.440 1.00 29.54 ? 273 VAL A N 1 ATOM 1836 C CA . VAL A 1 246 ? -17.257 -3.068 -9.829 1.00 29.57 ? 273 VAL A CA 1 ATOM 1837 C C . VAL A 1 246 ? -17.416 -4.503 -10.325 1.00 28.79 ? 273 VAL A C 1 ATOM 1838 O O . VAL A 1 246 ? -17.075 -4.806 -11.478 1.00 29.95 ? 273 VAL A O 1 ATOM 1839 C CB . VAL A 1 246 ? -18.474 -2.180 -10.157 1.00 28.58 ? 273 VAL A CB 1 ATOM 1840 C CG1 . VAL A 1 246 ? -18.628 -1.979 -11.657 1.00 28.53 ? 273 VAL A CG1 1 ATOM 1841 C CG2 . VAL A 1 246 ? -19.744 -2.790 -9.575 1.00 28.57 ? 273 VAL A CG2 1 ATOM 1842 N N . LEU A 1 247 ? -17.881 -5.378 -9.437 1.00 28.68 ? 274 LEU A N 1 ATOM 1843 C CA . LEU A 1 247 ? -18.147 -6.788 -9.761 1.00 30.19 ? 274 LEU A CA 1 ATOM 1844 C C . LEU A 1 247 ? -19.613 -7.081 -9.678 1.00 26.91 ? 274 LEU A C 1 ATOM 1845 O O . LEU A 1 247 ? -20.206 -6.936 -8.631 1.00 27.46 ? 274 LEU A O 1 ATOM 1846 C CB . LEU A 1 247 ? -17.472 -7.736 -8.785 1.00 33.82 ? 274 LEU A CB 1 ATOM 1847 C CG . LEU A 1 247 ? -16.021 -8.088 -9.008 1.00 39.23 ? 274 LEU A CG 1 ATOM 1848 C CD1 . LEU A 1 247 ? -15.163 -6.839 -8.805 1.00 41.36 ? 274 LEU A CD1 1 ATOM 1849 C CD2 . LEU A 1 247 ? -15.654 -9.201 -8.026 1.00 41.70 ? 274 LEU A CD2 1 ATOM 1850 N N . TYR A 1 248 ? -20.173 -7.556 -10.772 1.00 25.66 ? 275 TYR A N 1 ATOM 1851 C CA . TYR A 1 248 ? -21.592 -7.864 -10.857 1.00 25.09 ? 275 TYR A CA 1 ATOM 1852 C C . TYR A 1 248 ? -21.750 -9.359 -10.738 1.00 24.75 ? 275 TYR A C 1 ATOM 1853 O O . TYR A 1 248 ? -21.027 -10.098 -11.396 1.00 24.92 ? 275 TYR A O 1 ATOM 1854 C CB . TYR A 1 248 ? -22.150 -7.394 -12.206 1.00 24.35 ? 275 TYR A CB 1 ATOM 1855 C CG . TYR A 1 248 ? -22.181 -5.895 -12.357 1.00 26.80 ? 275 TYR A CG 1 ATOM 1856 C CD1 . TYR A 1 248 ? -23.085 -5.121 -11.630 1.00 25.92 ? 275 TYR A CD1 1 ATOM 1857 C CD2 . TYR A 1 248 ? -21.335 -5.244 -13.256 1.00 27.83 ? 275 TYR A CD2 1 ATOM 1858 C CE1 . TYR A 1 248 ? -23.143 -3.747 -11.796 1.00 27.56 ? 275 TYR A CE1 1 ATOM 1859 C CE2 . TYR A 1 248 ? -21.390 -3.868 -13.422 1.00 29.09 ? 275 TYR A CE2 1 ATOM 1860 C CZ . TYR A 1 248 ? -22.287 -3.129 -12.680 1.00 28.65 ? 275 TYR A CZ 1 ATOM 1861 O OH . TYR A 1 248 ? -22.318 -1.765 -12.828 1.00 32.55 ? 275 TYR A OH 1 ATOM 1862 N N . MET A 1 249 ? -22.673 -9.795 -9.892 1.00 25.25 ? 276 MET A N 1 ATOM 1863 C CA . MET A 1 249 ? -22.895 -11.216 -9.626 1.00 28.20 ? 276 MET A CA 1 ATOM 1864 C C . MET A 1 249 ? -24.314 -11.392 -9.077 1.00 28.75 ? 276 MET A C 1 ATOM 1865 O O . MET A 1 249 ? -24.927 -10.413 -8.643 1.00 27.88 ? 276 MET A O 1 ATOM 1866 C CB . MET A 1 249 ? -21.865 -11.778 -8.648 1.00 29.67 ? 276 MET A CB 1 ATOM 1867 C CG . MET A 1 249 ? -21.737 -10.971 -7.391 1.00 33.32 ? 276 MET A CG 1 ATOM 1868 S SD . MET A 1 249 ? -20.281 -11.283 -6.379 1.00 37.53 ? 276 MET A SD 1 ATOM 1869 C CE . MET A 1 249 ? -19.013 -10.662 -7.459 1.00 40.35 ? 276 MET A CE 1 ATOM 1870 N N . PRO A 1 250 ? -24.842 -12.624 -9.118 1.00 26.85 ? 277 PRO A N 1 ATOM 1871 C CA . PRO A 1 250 ? -26.220 -12.822 -8.709 1.00 25.61 ? 277 PRO A CA 1 ATOM 1872 C C . PRO A 1 250 ? -26.369 -12.915 -7.216 1.00 25.12 ? 277 PRO A C 1 ATOM 1873 O O . PRO A 1 250 ? -25.567 -13.586 -6.553 1.00 26.17 ? 277 PRO A O 1 ATOM 1874 C CB . PRO A 1 250 ? -26.595 -14.175 -9.346 1.00 25.99 ? 277 PRO A CB 1 ATOM 1875 C CG . PRO A 1 250 ? -25.519 -14.483 -10.332 1.00 26.20 ? 277 PRO A CG 1 ATOM 1876 C CD . PRO A 1 250 ? -24.295 -13.831 -9.760 1.00 27.29 ? 277 PRO A CD 1 ATOM 1877 N N . SER A 1 251 ? -27.397 -12.282 -6.676 1.00 23.59 ? 278 SER A N 1 ATOM 1878 C CA . SER A 1 251 ? -27.707 -12.485 -5.275 1.00 25.65 ? 278 SER A CA 1 ATOM 1879 C C . SER A 1 251 ? -28.388 -13.839 -5.006 1.00 24.08 ? 278 SER A C 1 ATOM 1880 O O . SER A 1 251 ? -28.514 -14.670 -5.879 1.00 26.58 ? 278 SER A O 1 ATOM 1881 C CB . SER A 1 251 ? -28.562 -11.337 -4.722 1.00 26.17 ? 278 SER A CB 1 ATOM 1882 O OG . SER A 1 251 ? -28.604 -11.478 -3.283 1.00 28.58 ? 278 SER A OG 1 ATOM 1883 N N . ALA A 1 252 ? -28.823 -14.054 -3.784 1.00 24.16 ? 279 ALA A N 1 ATOM 1884 C CA . ALA A 1 252 ? -29.560 -15.263 -3.419 1.00 24.87 ? 279 ALA A CA 1 ATOM 1885 C C . ALA A 1 252 ? -30.687 -15.439 -4.433 1.00 24.70 ? 279 ALA A C 1 ATOM 1886 O O . ALA A 1 252 ? -31.272 -14.444 -4.832 1.00 25.75 ? 279 ALA A O 1 ATOM 1887 C CB . ALA A 1 252 ? -30.128 -15.096 -2.012 1.00 25.42 ? 279 ALA A CB 1 ATOM 1888 N N . PRO A 1 253 ? -31.008 -16.653 -4.877 1.00 24.21 ? 280 PRO A N 1 ATOM 1889 C CA . PRO A 1 253 ? -30.541 -17.914 -4.325 1.00 23.69 ? 280 PRO A CA 1 ATOM 1890 C C . PRO A 1 253 ? -29.186 -18.433 -4.810 1.00 24.77 ? 280 PRO A C 1 ATOM 1891 O O . PRO A 1 253 ? -28.830 -19.553 -4.476 1.00 26.07 ? 280 PRO A O 1 ATOM 1892 C CB . PRO A 1 253 ? -31.628 -18.875 -4.768 1.00 23.34 ? 280 PRO A CB 1 ATOM 1893 C CG . PRO A 1 253 ? -32.027 -18.352 -6.090 1.00 23.78 ? 280 PRO A CG 1 ATOM 1894 C CD . PRO A 1 253 ? -31.974 -16.863 -5.973 1.00 23.92 ? 280 PRO A CD 1 ATOM 1895 N N . LEU A 1 254 ? -28.443 -17.649 -5.581 1.00 25.06 ? 281 LEU A N 1 ATOM 1896 C CA . LEU A 1 254 ? -27.069 -17.997 -5.901 1.00 24.90 ? 281 LEU A CA 1 ATOM 1897 C C . LEU A 1 254 ? -26.095 -17.426 -4.849 1.00 26.23 ? 281 LEU A C 1 ATOM 1898 O O . LEU A 1 254 ? -26.519 -16.837 -3.856 1.00 25.33 ? 281 LEU A O 1 ATOM 1899 C CB . LEU A 1 254 ? -26.725 -17.549 -7.319 1.00 24.19 ? 281 LEU A CB 1 ATOM 1900 C CG . LEU A 1 254 ? -26.955 -18.641 -8.378 1.00 23.99 ? 281 LEU A CG 1 ATOM 1901 C CD1 . LEU A 1 254 ? -28.406 -19.105 -8.411 1.00 23.94 ? 281 LEU A CD1 1 ATOM 1902 C CD2 . LEU A 1 254 ? -26.534 -18.133 -9.740 1.00 24.71 ? 281 LEU A CD2 1 ATOM 1903 N N . SER A 1 255 ? -24.793 -17.623 -5.068 1.00 26.64 ? 282 SER A N 1 ATOM 1904 C CA . SER A 1 255 ? -23.788 -17.410 -4.049 1.00 26.17 ? 282 SER A CA 1 ATOM 1905 C C . SER A 1 255 ? -22.936 -16.151 -4.230 1.00 25.70 ? 282 SER A C 1 ATOM 1906 O O . SER A 1 255 ? -21.867 -16.052 -3.655 1.00 25.65 ? 282 SER A O 1 ATOM 1907 C CB . SER A 1 255 ? -22.895 -18.652 -3.976 1.00 27.03 ? 282 SER A CB 1 ATOM 1908 O OG . SER A 1 255 ? -23.575 -19.653 -3.260 1.00 28.80 ? 282 SER A OG 1 ATOM 1909 N N . GLY A 1 256 ? -23.415 -15.178 -4.991 1.00 23.43 ? 283 GLY A N 1 ATOM 1910 C CA . GLY A 1 256 ? -22.784 -13.880 -5.029 1.00 23.83 ? 283 GLY A CA 1 ATOM 1911 C C . GLY A 1 256 ? -22.484 -13.299 -3.648 1.00 24.93 ? 283 GLY A C 1 ATOM 1912 O O . GLY A 1 256 ? -21.413 -12.754 -3.437 1.00 24.95 ? 283 GLY A O 1 ATOM 1913 N N . PRO A 1 257 ? -23.421 -13.412 -2.695 1.00 24.15 ? 284 PRO A N 1 ATOM 1914 C CA . PRO A 1 257 ? -23.115 -12.866 -1.376 1.00 25.69 ? 284 PRO A CA 1 ATOM 1915 C C . PRO A 1 257 ? -21.939 -13.531 -0.670 1.00 25.69 ? 284 PRO A C 1 ATOM 1916 O O . PRO A 1 257 ? -21.230 -12.870 0.100 1.00 26.29 ? 284 PRO A O 1 ATOM 1917 C CB . PRO A 1 257 ? -24.414 -13.111 -0.582 1.00 24.96 ? 284 PRO A CB 1 ATOM 1918 C CG . PRO A 1 257 ? -25.469 -13.238 -1.630 1.00 24.22 ? 284 PRO A CG 1 ATOM 1919 C CD . PRO A 1 257 ? -24.781 -13.963 -2.747 1.00 24.13 ? 284 PRO A CD 1 ATOM 1920 N N . VAL A 1 258 ? -21.765 -14.833 -0.904 1.00 26.34 ? 285 VAL A N 1 ATOM 1921 C CA . VAL A 1 258 ? -20.629 -15.585 -0.351 1.00 25.86 ? 285 VAL A CA 1 ATOM 1922 C C . VAL A 1 258 ? -19.321 -15.101 -1.003 1.00 25.68 ? 285 VAL A C 1 ATOM 1923 O O . VAL A 1 258 ? -18.318 -14.808 -0.317 1.00 24.28 ? 285 VAL A O 1 ATOM 1924 C CB . VAL A 1 258 ? -20.812 -17.102 -0.526 1.00 25.33 ? 285 VAL A CB 1 ATOM 1925 C CG1 . VAL A 1 258 ? -19.619 -17.862 0.041 1.00 25.03 ? 285 VAL A CG1 1 ATOM 1926 C CG2 . VAL A 1 258 ? -22.094 -17.567 0.159 1.00 26.99 ? 285 VAL A CG2 1 ATOM 1927 N N . LEU A 1 259 ? -19.361 -14.983 -2.319 1.00 24.21 ? 286 LEU A N 1 ATOM 1928 C CA . LEU A 1 259 ? -18.238 -14.468 -3.081 1.00 24.71 ? 286 LEU A CA 1 ATOM 1929 C C . LEU A 1 259 ? -17.885 -13.054 -2.616 1.00 24.65 ? 286 LEU A C 1 ATOM 1930 O O . LEU A 1 259 ? -16.718 -12.732 -2.377 1.00 25.04 ? 286 LEU A O 1 ATOM 1931 C CB . LEU A 1 259 ? -18.561 -14.458 -4.573 1.00 23.77 ? 286 LEU A CB 1 ATOM 1932 C CG . LEU A 1 259 ? -17.398 -14.017 -5.467 1.00 24.92 ? 286 LEU A CG 1 ATOM 1933 C CD1 . LEU A 1 259 ? -16.183 -14.925 -5.314 1.00 24.52 ? 286 LEU A CD1 1 ATOM 1934 C CD2 . LEU A 1 259 ? -17.840 -14.021 -6.903 1.00 25.42 ? 286 LEU A CD2 1 ATOM 1935 N N . ALA A 1 260 ? -18.900 -12.219 -2.484 1.00 24.04 ? 287 ALA A N 1 ATOM 1936 C CA . ALA A 1 260 ? -18.706 -10.850 -2.062 1.00 23.79 ? 287 ALA A CA 1 ATOM 1937 C C . ALA A 1 260 ? -17.994 -10.799 -0.714 1.00 22.86 ? 287 ALA A C 1 ATOM 1938 O O . ALA A 1 260 ? -17.023 -10.059 -0.530 1.00 21.34 ? 287 ALA A O 1 ATOM 1939 C CB . ALA A 1 260 ? -20.037 -10.115 -2.017 1.00 23.63 ? 287 ALA A CB 1 ATOM 1940 N N . LEU A 1 261 ? -18.467 -11.605 0.227 1.00 23.16 ? 288 LEU A N 1 ATOM 1941 C CA . LEU A 1 261 ? -17.879 -11.631 1.562 1.00 21.91 ? 288 LEU A CA 1 ATOM 1942 C C . LEU A 1 261 ? -16.444 -12.151 1.563 1.00 22.45 ? 288 LEU A C 1 ATOM 1943 O O . LEU A 1 261 ? -15.564 -11.609 2.251 1.00 22.97 ? 288 LEU A O 1 ATOM 1944 C CB . LEU A 1 261 ? -18.774 -12.449 2.509 1.00 21.55 ? 288 LEU A CB 1 ATOM 1945 C CG . LEU A 1 261 ? -18.361 -12.417 3.962 1.00 21.70 ? 288 LEU A CG 1 ATOM 1946 C CD1 . LEU A 1 261 ? -18.124 -10.994 4.453 1.00 21.86 ? 288 LEU A CD1 1 ATOM 1947 C CD2 . LEU A 1 261 ? -19.367 -13.126 4.848 1.00 22.18 ? 288 LEU A CD2 1 ATOM 1948 N N . ILE A 1 262 ? -16.179 -13.194 0.794 1.00 21.36 ? 289 ILE A N 1 ATOM 1949 C CA . ILE A 1 262 ? -14.805 -13.677 0.697 1.00 21.02 ? 289 ILE A CA 1 ATOM 1950 C C . ILE A 1 262 ? -13.876 -12.550 0.234 1.00 22.32 ? 289 ILE A C 1 ATOM 1951 O O . ILE A 1 262 ? -12.850 -12.274 0.857 1.00 21.09 ? 289 ILE A O 1 ATOM 1952 C CB . ILE A 1 262 ? -14.701 -14.838 -0.275 1.00 19.92 ? 289 ILE A CB 1 ATOM 1953 C CG1 . ILE A 1 262 ? -15.365 -16.080 0.321 1.00 20.33 ? 289 ILE A CG1 1 ATOM 1954 C CG2 . ILE A 1 262 ? -13.254 -15.144 -0.570 1.00 21.05 ? 289 ILE A CG2 1 ATOM 1955 C CD1 . ILE A 1 262 ? -15.585 -17.178 -0.701 1.00 20.67 ? 289 ILE A CD1 1 ATOM 1956 N N . LEU A 1 263 ? -14.251 -11.892 -0.862 1.00 22.91 ? 290 LEU A N 1 ATOM 1957 C CA . LEU A 1 263 ? -13.398 -10.875 -1.444 1.00 22.17 ? 290 LEU A CA 1 ATOM 1958 C C . LEU A 1 263 ? -13.301 -9.622 -0.594 1.00 22.03 ? 290 LEU A C 1 ATOM 1959 O O . LEU A 1 263 ? -12.223 -9.072 -0.510 1.00 20.72 ? 290 LEU A O 1 ATOM 1960 C CB . LEU A 1 263 ? -13.825 -10.530 -2.853 1.00 23.62 ? 290 LEU A CB 1 ATOM 1961 C CG . LEU A 1 263 ? -13.792 -11.676 -3.857 1.00 23.74 ? 290 LEU A CG 1 ATOM 1962 C CD1 . LEU A 1 263 ? -14.394 -11.227 -5.165 1.00 23.63 ? 290 LEU A CD1 1 ATOM 1963 C CD2 . LEU A 1 263 ? -12.380 -12.163 -4.082 1.00 24.33 ? 290 LEU A CD2 1 ATOM 1964 N N . ASN A 1 264 ? -14.386 -9.187 0.057 1.00 20.89 ? 291 ASN A N 1 ATOM 1965 C CA . ASN A 1 264 ? -14.313 -8.031 0.932 1.00 22.12 ? 291 ASN A CA 1 ATOM 1966 C C . ASN A 1 264 ? -13.492 -8.299 2.212 1.00 24.43 ? 291 ASN A C 1 ATOM 1967 O O . ASN A 1 264 ? -12.843 -7.394 2.749 1.00 24.82 ? 291 ASN A O 1 ATOM 1968 C CB . ASN A 1 264 ? -15.706 -7.542 1.312 1.00 23.07 ? 291 ASN A CB 1 ATOM 1969 C CG . ASN A 1 264 ? -16.345 -6.687 0.231 1.00 24.57 ? 291 ASN A CG 1 ATOM 1970 O OD1 . ASN A 1 264 ? -15.681 -6.204 -0.670 1.00 27.83 ? 291 ASN A OD1 1 ATOM 1971 N ND2 . ASN A 1 264 ? -17.646 -6.512 0.316 1.00 25.76 ? 291 ASN A ND2 1 ATOM 1972 N N . ILE A 1 265 ? -13.524 -9.532 2.713 1.00 25.40 ? 292 ILE A N 1 ATOM 1973 C CA . ILE A 1 265 ? -12.647 -9.906 3.820 1.00 24.78 ? 292 ILE A CA 1 ATOM 1974 C C . ILE A 1 265 ? -11.203 -9.730 3.366 1.00 26.07 ? 292 ILE A C 1 ATOM 1975 O O . ILE A 1 265 ? -10.429 -9.044 4.004 1.00 28.01 ? 292 ILE A O 1 ATOM 1976 C CB . ILE A 1 265 ? -12.901 -11.345 4.292 1.00 24.11 ? 292 ILE A CB 1 ATOM 1977 C CG1 . ILE A 1 265 ? -14.227 -11.420 5.050 1.00 23.09 ? 292 ILE A CG1 1 ATOM 1978 C CG2 . ILE A 1 265 ? -11.742 -11.846 5.168 1.00 25.75 ? 292 ILE A CG2 1 ATOM 1979 C CD1 . ILE A 1 265 ? -14.689 -12.833 5.362 1.00 23.49 ? 292 ILE A CD1 1 ATOM 1980 N N . LEU A 1 266 ? -10.869 -10.335 2.239 1.00 26.46 ? 293 LEU A N 1 ATOM 1981 C CA . LEU A 1 266 ? -9.499 -10.385 1.782 1.00 27.78 ? 293 LEU A CA 1 ATOM 1982 C C . LEU A 1 266 ? -8.954 -9.056 1.276 1.00 29.17 ? 293 LEU A C 1 ATOM 1983 O O . LEU A 1 266 ? -7.743 -8.821 1.338 1.00 28.30 ? 293 LEU A O 1 ATOM 1984 C CB . LEU A 1 266 ? -9.353 -11.443 0.703 1.00 25.61 ? 293 LEU A CB 1 ATOM 1985 C CG . LEU A 1 266 ? -9.567 -12.842 1.238 1.00 25.77 ? 293 LEU A CG 1 ATOM 1986 C CD1 . LEU A 1 266 ? -9.671 -13.820 0.080 1.00 26.67 ? 293 LEU A CD1 1 ATOM 1987 C CD2 . LEU A 1 266 ? -8.450 -13.223 2.196 1.00 25.47 ? 293 LEU A CD2 1 ATOM 1988 N N . LYS A 1 267 ? -9.825 -8.185 0.789 1.00 30.36 ? 294 LYS A N 1 ATOM 1989 C CA . LYS A 1 267 ? -9.343 -6.949 0.199 1.00 31.02 ? 294 LYS A CA 1 ATOM 1990 C C . LYS A 1 267 ? -8.602 -6.069 1.214 1.00 29.67 ? 294 LYS A C 1 ATOM 1991 O O . LYS A 1 267 ? -7.658 -5.396 0.837 1.00 27.96 ? 294 LYS A O 1 ATOM 1992 C CB . LYS A 1 267 ? -10.436 -6.199 -0.550 1.00 32.81 ? 294 LYS A CB 1 ATOM 1993 C CG . LYS A 1 267 ? -11.193 -5.116 0.188 1.00 37.62 ? 294 LYS A CG 1 ATOM 1994 C CD . LYS A 1 267 ? -12.254 -4.597 -0.771 1.00 42.50 ? 294 LYS A CD 1 ATOM 1995 C CE . LYS A 1 267 ? -13.190 -3.558 -0.194 1.00 45.91 ? 294 LYS A CE 1 ATOM 1996 N NZ . LYS A 1 267 ? -14.425 -3.482 -1.053 1.00 51.74 ? 294 LYS A NZ 1 ATOM 1997 N N . GLY A 1 268 ? -8.977 -6.109 2.485 1.00 29.25 ? 295 GLY A N 1 ATOM 1998 C CA . GLY A 1 268 ? -8.250 -5.330 3.513 1.00 29.95 ? 295 GLY A CA 1 ATOM 1999 C C . GLY A 1 268 ? -6.821 -5.797 3.829 1.00 29.73 ? 295 GLY A C 1 ATOM 2000 O O . GLY A 1 268 ? -6.120 -5.140 4.571 1.00 29.63 ? 295 GLY A O 1 ATOM 2001 N N . TYR A 1 269 ? -6.394 -6.941 3.287 1.00 28.83 ? 296 TYR A N 1 ATOM 2002 C CA . TYR A 1 269 ? -5.004 -7.374 3.394 1.00 28.97 ? 296 TYR A CA 1 ATOM 2003 C C . TYR A 1 269 ? -4.114 -6.783 2.293 1.00 31.92 ? 296 TYR A C 1 ATOM 2004 O O . TYR A 1 269 ? -2.907 -6.958 2.335 1.00 30.67 ? 296 TYR A O 1 ATOM 2005 C CB . TYR A 1 269 ? -4.907 -8.891 3.298 1.00 28.11 ? 296 TYR A CB 1 ATOM 2006 C CG . TYR A 1 269 ? -5.391 -9.662 4.501 1.00 26.98 ? 296 TYR A CG 1 ATOM 2007 C CD1 . TYR A 1 269 ? -4.814 -9.470 5.757 1.00 27.27 ? 296 TYR A CD1 1 ATOM 2008 C CD2 . TYR A 1 269 ? -6.411 -10.590 4.384 1.00 26.54 ? 296 TYR A CD2 1 ATOM 2009 C CE1 . TYR A 1 269 ? -5.241 -10.194 6.859 1.00 28.38 ? 296 TYR A CE1 1 ATOM 2010 C CE2 . TYR A 1 269 ? -6.845 -11.327 5.481 1.00 27.26 ? 296 TYR A CE2 1 ATOM 2011 C CZ . TYR A 1 269 ? -6.257 -11.129 6.714 1.00 27.90 ? 296 TYR A CZ 1 ATOM 2012 O OH . TYR A 1 269 ? -6.679 -11.863 7.809 1.00 30.13 ? 296 TYR A OH 1 ATOM 2013 N N . ASN A 1 270 ? -4.711 -6.117 1.299 1.00 33.28 ? 297 ASN A N 1 ATOM 2014 C CA . ASN A 1 270 ? -3.961 -5.478 0.205 1.00 36.52 ? 297 ASN A CA 1 ATOM 2015 C C . ASN A 1 270 ? -3.019 -6.445 -0.478 1.00 34.46 ? 297 ASN A C 1 ATOM 2016 O O . ASN A 1 270 ? -1.819 -6.192 -0.570 1.00 35.04 ? 297 ASN A O 1 ATOM 2017 C CB . ASN A 1 270 ? -3.182 -4.228 0.699 1.00 39.22 ? 297 ASN A CB 1 ATOM 2018 C CG . ASN A 1 270 ? -4.081 -3.207 1.411 1.00 43.57 ? 297 ASN A CG 1 ATOM 2019 O OD1 . ASN A 1 270 ? -3.781 -2.769 2.525 1.00 49.73 ? 297 ASN A OD1 1 ATOM 2020 N ND2 . ASN A 1 270 ? -5.196 -2.847 0.783 1.00 43.29 ? 297 ASN A ND2 1 ATOM 2021 N N . PHE A 1 271 ? -3.563 -7.561 -0.955 1.00 33.42 ? 298 PHE A N 1 ATOM 2022 C CA . PHE A 1 271 ? -2.739 -8.573 -1.622 1.00 31.22 ? 298 PHE A CA 1 ATOM 2023 C C . PHE A 1 271 ? -2.137 -7.980 -2.907 1.00 31.34 ? 298 PHE A C 1 ATOM 2024 O O . PHE A 1 271 ? -2.761 -7.153 -3.597 1.00 29.37 ? 298 PHE A O 1 ATOM 2025 C CB . PHE A 1 271 ? -3.534 -9.844 -1.997 1.00 30.01 ? 298 PHE A CB 1 ATOM 2026 C CG . PHE A 1 271 ? -3.884 -10.770 -0.841 1.00 27.72 ? 298 PHE A CG 1 ATOM 2027 C CD1 . PHE A 1 271 ? -3.211 -10.754 0.360 1.00 28.35 ? 298 PHE A CD1 1 ATOM 2028 C CD2 . PHE A 1 271 ? -4.886 -11.716 -1.014 1.00 28.36 ? 298 PHE A CD2 1 ATOM 2029 C CE1 . PHE A 1 271 ? -3.557 -11.639 1.383 1.00 28.29 ? 298 PHE A CE1 1 ATOM 2030 C CE2 . PHE A 1 271 ? -5.240 -12.597 -0.003 1.00 26.14 ? 298 PHE A CE2 1 ATOM 2031 C CZ . PHE A 1 271 ? -4.582 -12.552 1.200 1.00 26.91 ? 298 PHE A CZ 1 ATOM 2032 N N . SER A 1 272 ? -0.935 -8.436 -3.232 1.00 31.08 ? 299 SER A N 1 ATOM 2033 C CA . SER A 1 272 ? -0.232 -7.997 -4.429 1.00 33.59 ? 299 SER A CA 1 ATOM 2034 C C . SER A 1 272 ? 0.654 -9.147 -4.885 1.00 34.33 ? 299 SER A C 1 ATOM 2035 O O . SER A 1 272 ? 0.649 -10.228 -4.282 1.00 33.33 ? 299 SER A O 1 ATOM 2036 C CB . SER A 1 272 ? 0.648 -6.762 -4.103 1.00 32.39 ? 299 SER A CB 1 ATOM 2037 O OG . SER A 1 272 ? 1.768 -7.146 -3.302 1.00 32.48 ? 299 SER A OG 1 ATOM 2038 N N . ARG A 1 273 ? 1.461 -8.892 -5.900 1.00 35.23 ? 300 ARG A N 1 ATOM 2039 C CA . ARG A 1 273 ? 2.507 -9.830 -6.301 1.00 41.20 ? 300 ARG A CA 1 ATOM 2040 C C . ARG A 1 273 ? 3.416 -10.231 -5.120 1.00 35.34 ? 300 ARG A C 1 ATOM 2041 O O . ARG A 1 273 ? 3.841 -11.369 -5.033 1.00 34.89 ? 300 ARG A O 1 ATOM 2042 C CB . ARG A 1 273 ? 3.322 -9.205 -7.436 1.00 49.52 ? 300 ARG A CB 1 ATOM 2043 C CG . ARG A 1 273 ? 4.276 -10.137 -8.174 1.00 63.80 ? 300 ARG A CG 1 ATOM 2044 C CD . ARG A 1 273 ? 4.977 -9.412 -9.342 1.00 73.68 ? 300 ARG A CD 1 ATOM 2045 N NE . ARG A 1 273 ? 4.081 -8.435 -9.986 1.00 82.33 ? 300 ARG A NE 1 ATOM 2046 C CZ . ARG A 1 273 ? 3.165 -8.704 -10.928 1.00 83.37 ? 300 ARG A CZ 1 ATOM 2047 N NH1 . ARG A 1 273 ? 3.006 -9.934 -11.417 1.00 84.71 ? 300 ARG A NH1 1 ATOM 2048 N NH2 . ARG A 1 273 ? 2.401 -7.718 -11.399 1.00 84.03 ? 300 ARG A NH2 1 ATOM 2049 N N . GLU A 1 274 ? 3.682 -9.310 -4.202 1.00 35.36 ? 301 GLU A N 1 ATOM 2050 C CA . GLU A 1 274 ? 4.546 -9.610 -3.065 1.00 39.58 ? 301 GLU A CA 1 ATOM 2051 C C . GLU A 1 274 ? 3.952 -10.684 -2.136 1.00 39.50 ? 301 GLU A C 1 ATOM 2052 O O . GLU A 1 274 ? 4.693 -11.392 -1.451 1.00 38.47 ? 301 GLU A O 1 ATOM 2053 C CB . GLU A 1 274 ? 4.794 -8.358 -2.221 1.00 48.95 ? 301 GLU A CB 1 ATOM 2054 C CG . GLU A 1 274 ? 5.750 -7.311 -2.778 1.00 57.68 ? 301 GLU A CG 1 ATOM 2055 C CD . GLU A 1 274 ? 5.980 -6.156 -1.785 1.00 71.12 ? 301 GLU A CD 1 ATOM 2056 O OE1 . GLU A 1 274 ? 5.256 -6.076 -0.760 1.00 74.13 ? 301 GLU A OE1 1 ATOM 2057 O OE2 . GLU A 1 274 ? 6.885 -5.316 -2.016 1.00 79.31 ? 301 GLU A OE2 1 ATOM 2058 N N . SER A 1 275 ? 2.621 -10.767 -2.081 1.00 34.39 ? 302 SER A N 1 ATOM 2059 C CA . SER A 1 275 ? 1.928 -11.722 -1.219 1.00 34.10 ? 302 SER A CA 1 ATOM 2060 C C . SER A 1 275 ? 2.285 -13.163 -1.500 1.00 32.70 ? 302 SER A C 1 ATOM 2061 O O . SER A 1 275 ? 2.091 -14.021 -0.634 1.00 32.22 ? 302 SER A O 1 ATOM 2062 C CB . SER A 1 275 ? 0.416 -11.565 -1.363 1.00 33.34 ? 302 SER A CB 1 ATOM 2063 O OG . SER A 1 275 ? 0.051 -10.218 -1.171 1.00 33.58 ? 302 SER A OG 1 ATOM 2064 N N . VAL A 1 276 ? 2.784 -13.433 -2.702 1.00 33.21 ? 303 VAL A N 1 ATOM 2065 C CA . VAL A 1 276 ? 3.193 -14.780 -3.072 1.00 37.11 ? 303 VAL A CA 1 ATOM 2066 C C . VAL A 1 276 ? 4.660 -14.952 -3.516 1.00 39.65 ? 303 VAL A C 1 ATOM 2067 O O . VAL A 1 276 ? 5.007 -15.997 -4.043 1.00 38.89 ? 303 VAL A O 1 ATOM 2068 C CB . VAL A 1 276 ? 2.294 -15.326 -4.193 1.00 36.61 ? 303 VAL A CB 1 ATOM 2069 C CG1 . VAL A 1 276 ? 0.866 -15.481 -3.696 1.00 37.97 ? 303 VAL A CG1 1 ATOM 2070 C CG2 . VAL A 1 276 ? 2.356 -14.450 -5.434 1.00 36.11 ? 303 VAL A CG2 1 ATOM 2071 N N . GLU A 1 277 ? 5.512 -13.965 -3.260 1.00 45.51 ? 304 GLU A N 1 ATOM 2072 C CA . GLU A 1 277 ? 6.900 -13.990 -3.748 1.00 51.17 ? 304 GLU A CA 1 ATOM 2073 C C . GLU A 1 277 ? 7.859 -14.838 -2.921 1.00 50.15 ? 304 GLU A C 1 ATOM 2074 O O . GLU A 1 277 ? 8.815 -15.371 -3.457 1.00 58.84 ? 304 GLU A O 1 ATOM 2075 C CB . GLU A 1 277 ? 7.445 -12.571 -3.898 1.00 59.17 ? 304 GLU A CB 1 ATOM 2076 C CG . GLU A 1 277 ? 7.239 -12.042 -5.310 1.00 69.50 ? 304 GLU A CG 1 ATOM 2077 C CD . GLU A 1 277 ? 7.626 -10.577 -5.489 1.00 78.06 ? 304 GLU A CD 1 ATOM 2078 O OE1 . GLU A 1 277 ? 8.132 -9.936 -4.524 1.00 77.70 ? 304 GLU A OE1 1 ATOM 2079 O OE2 . GLU A 1 277 ? 7.413 -10.072 -6.618 1.00 85.76 ? 304 GLU A OE2 1 ATOM 2080 N N . SER A 1 278 ? 7.614 -14.969 -1.627 1.00 46.72 ? 305 SER A N 1 ATOM 2081 C CA . SER A 1 278 ? 8.390 -15.877 -0.804 1.00 45.58 ? 305 SER A CA 1 ATOM 2082 C C . SER A 1 278 ? 7.465 -16.904 -0.193 1.00 44.12 ? 305 SER A C 1 ATOM 2083 O O . SER A 1 278 ? 6.274 -16.659 -0.088 1.00 38.90 ? 305 SER A O 1 ATOM 2084 C CB . SER A 1 278 ? 9.093 -15.109 0.324 1.00 48.09 ? 305 SER A CB 1 ATOM 2085 O OG . SER A 1 278 ? 8.160 -14.482 1.195 1.00 44.64 ? 305 SER A OG 1 ATOM 2086 N N . PRO A 1 279 ? 8.015 -18.044 0.246 1.00 42.19 ? 306 PRO A N 1 ATOM 2087 C CA . PRO A 1 279 ? 7.238 -19.048 0.974 1.00 41.41 ? 306 PRO A CA 1 ATOM 2088 C C . PRO A 1 279 ? 6.583 -18.498 2.222 1.00 44.20 ? 306 PRO A C 1 ATOM 2089 O O . PRO A 1 279 ? 5.502 -18.956 2.580 1.00 42.59 ? 306 PRO A O 1 ATOM 2090 C CB . PRO A 1 279 ? 8.275 -20.111 1.365 1.00 41.62 ? 306 PRO A CB 1 ATOM 2091 C CG . PRO A 1 279 ? 9.392 -19.932 0.400 1.00 43.73 ? 306 PRO A CG 1 ATOM 2092 C CD . PRO A 1 279 ? 9.360 -18.523 -0.115 1.00 43.51 ? 306 PRO A CD 1 ATOM 2093 N N . GLU A 1 280 ? 7.235 -17.540 2.886 1.00 42.34 ? 307 GLU A N 1 ATOM 2094 C CA . GLU A 1 280 ? 6.708 -17.002 4.131 1.00 46.81 ? 307 GLU A CA 1 ATOM 2095 C C . GLU A 1 280 ? 5.430 -16.228 3.861 1.00 41.65 ? 307 GLU A C 1 ATOM 2096 O O . GLU A 1 280 ? 4.426 -16.460 4.513 1.00 39.94 ? 307 GLU A O 1 ATOM 2097 C CB . GLU A 1 280 ? 7.716 -16.076 4.835 1.00 52.81 ? 307 GLU A CB 1 ATOM 2098 C CG . GLU A 1 280 ? 8.875 -16.793 5.508 1.00 57.39 ? 307 GLU A CG 1 ATOM 2099 C CD . GLU A 1 280 ? 9.968 -17.273 4.548 1.00 61.47 ? 307 GLU A CD 1 ATOM 2100 O OE1 . GLU A 1 280 ? 10.915 -17.911 5.055 1.00 67.02 ? 307 GLU A OE1 1 ATOM 2101 O OE2 . GLU A 1 280 ? 9.907 -17.031 3.313 1.00 59.69 ? 307 GLU A OE2 1 ATOM 2102 N N . GLN A 1 281 ? 5.487 -15.299 2.911 1.00 38.31 ? 308 GLN A N 1 ATOM 2103 C CA . GLN A 1 281 ? 4.321 -14.510 2.542 1.00 39.55 ? 308 GLN A CA 1 ATOM 2104 C C . GLN A 1 281 ? 3.229 -15.379 1.898 1.00 34.06 ? 308 GLN A C 1 ATOM 2105 O O . GLN A 1 281 ? 2.044 -15.236 2.187 1.00 32.37 ? 308 GLN A O 1 ATOM 2106 C CB . GLN A 1 281 ? 4.713 -13.365 1.607 1.00 43.99 ? 308 GLN A CB 1 ATOM 2107 C CG . GLN A 1 281 ? 5.560 -12.281 2.269 1.00 51.80 ? 308 GLN A CG 1 ATOM 2108 C CD . GLN A 1 281 ? 5.130 -10.864 1.868 1.00 64.38 ? 308 GLN A CD 1 ATOM 2109 O OE1 . GLN A 1 281 ? 5.933 -10.075 1.332 1.00 66.83 ? 308 GLN A OE1 1 ATOM 2110 N NE2 . GLN A 1 281 ? 3.845 -10.539 2.108 1.00 63.02 ? 308 GLN A NE2 1 ATOM 2111 N N . LYS A 1 282 ? 3.648 -16.296 1.048 1.00 31.07 ? 309 LYS A N 1 ATOM 2112 C CA . LYS A 1 282 ? 2.727 -17.151 0.318 1.00 29.45 ? 309 LYS A CA 1 ATOM 2113 C C . LYS A 1 282 ? 1.891 -18.013 1.249 1.00 28.39 ? 309 LYS A C 1 ATOM 2114 O O . LYS A 1 282 ? 0.681 -18.144 1.047 1.00 27.16 ? 309 LYS A O 1 ATOM 2115 C CB . LYS A 1 282 ? 3.477 -18.055 -0.653 1.00 28.56 ? 309 LYS A CB 1 ATOM 2116 C CG . LYS A 1 282 ? 2.595 -18.682 -1.699 1.00 30.29 ? 309 LYS A CG 1 ATOM 2117 C CD . LYS A 1 282 ? 3.418 -19.344 -2.799 1.00 31.03 ? 309 LYS A CD 1 ATOM 2118 C CE . LYS A 1 282 ? 2.537 -19.925 -3.882 1.00 32.22 ? 309 LYS A CE 1 ATOM 2119 N NZ . LYS A 1 282 ? 3.347 -20.620 -4.925 1.00 35.50 ? 309 LYS A NZ 1 ATOM 2120 N N . GLY A 1 283 ? 2.550 -18.630 2.228 1.00 27.00 ? 310 GLY A N 1 ATOM 2121 C CA . GLY A 1 283 ? 1.901 -19.546 3.141 1.00 26.77 ? 310 GLY A CA 1 ATOM 2122 C C . GLY A 1 283 ? 0.897 -18.779 3.994 1.00 27.86 ? 310 GLY A C 1 ATOM 2123 O O . GLY A 1 283 ? -0.233 -19.221 4.175 1.00 25.24 ? 310 GLY A O 1 ATOM 2124 N N . LEU A 1 284 ? 1.306 -17.604 4.479 1.00 26.51 ? 311 LEU A N 1 ATOM 2125 C CA . LEU A 1 284 ? 0.391 -16.758 5.228 1.00 27.91 ? 311 LEU A CA 1 ATOM 2126 C C . LEU A 1 284 ? -0.797 -16.302 4.376 1.00 26.95 ? 311 LEU A C 1 ATOM 2127 O O . LEU A 1 284 ? -1.955 -16.324 4.824 1.00 27.61 ? 311 LEU A O 1 ATOM 2128 C CB . LEU A 1 284 ? 1.126 -15.551 5.830 1.00 27.06 ? 311 LEU A CB 1 ATOM 2129 C CG . LEU A 1 284 ? 0.259 -14.532 6.597 1.00 27.65 ? 311 LEU A CG 1 ATOM 2130 C CD1 . LEU A 1 284 ? -0.590 -15.212 7.655 1.00 27.82 ? 311 LEU A CD1 1 ATOM 2131 C CD2 . LEU A 1 284 ? 1.131 -13.435 7.215 1.00 28.69 ? 311 LEU A CD2 1 ATOM 2132 N N . THR A 1 285 ? -0.504 -15.869 3.163 1.00 25.73 ? 312 THR A N 1 ATOM 2133 C CA . THR A 1 285 ? -1.545 -15.456 2.235 1.00 25.73 ? 312 THR A CA 1 ATOM 2134 C C . THR A 1 285 ? -2.592 -16.576 2.033 1.00 26.19 ? 312 THR A C 1 ATOM 2135 O O . THR A 1 285 ? -3.783 -16.339 2.131 1.00 24.04 ? 312 THR A O 1 ATOM 2136 C CB . THR A 1 285 ? -0.925 -15.061 0.884 1.00 25.98 ? 312 THR A CB 1 ATOM 2137 O OG1 . THR A 1 285 ? -0.119 -13.876 1.050 1.00 24.44 ? 312 THR A OG1 1 ATOM 2138 C CG2 . THR A 1 285 ? -2.008 -14.810 -0.176 1.00 25.99 ? 312 THR A CG2 1 ATOM 2139 N N . TYR A 1 286 ? -2.150 -17.797 1.769 1.00 25.81 ? 313 TYR A N 1 ATOM 2140 C CA . TYR A 1 286 ? -3.089 -18.876 1.521 1.00 25.62 ? 313 TYR A CA 1 ATOM 2141 C C . TYR A 1 286 ? -3.825 -19.249 2.796 1.00 25.55 ? 313 TYR A C 1 ATOM 2142 O O . TYR A 1 286 ? -4.995 -19.654 2.756 1.00 23.87 ? 313 TYR A O 1 ATOM 2143 C CB . TYR A 1 286 ? -2.398 -20.089 0.907 1.00 26.93 ? 313 TYR A CB 1 ATOM 2144 C CG . TYR A 1 286 ? -2.293 -19.976 -0.588 1.00 27.53 ? 313 TYR A CG 1 ATOM 2145 C CD1 . TYR A 1 286 ? -1.371 -19.118 -1.180 1.00 27.21 ? 313 TYR A CD1 1 ATOM 2146 C CD2 . TYR A 1 286 ? -3.132 -20.714 -1.421 1.00 28.64 ? 313 TYR A CD2 1 ATOM 2147 C CE1 . TYR A 1 286 ? -1.272 -19.009 -2.560 1.00 27.23 ? 313 TYR A CE1 1 ATOM 2148 C CE2 . TYR A 1 286 ? -3.032 -20.612 -2.800 1.00 29.48 ? 313 TYR A CE2 1 ATOM 2149 C CZ . TYR A 1 286 ? -2.103 -19.751 -3.360 1.00 27.82 ? 313 TYR A CZ 1 ATOM 2150 O OH . TYR A 1 286 ? -2.043 -19.627 -4.717 1.00 26.04 ? 313 TYR A OH 1 ATOM 2151 N N . HIS A 1 287 ? -3.161 -19.087 3.931 1.00 24.00 ? 314 HIS A N 1 ATOM 2152 C CA . HIS A 1 287 ? -3.850 -19.281 5.199 1.00 25.18 ? 314 HIS A CA 1 ATOM 2153 C C . HIS A 1 287 ? -5.001 -18.290 5.359 1.00 23.11 ? 314 HIS A C 1 ATOM 2154 O O . HIS A 1 287 ? -6.128 -18.668 5.695 1.00 23.94 ? 314 HIS A O 1 ATOM 2155 C CB . HIS A 1 287 ? -2.891 -19.170 6.365 1.00 25.40 ? 314 HIS A CB 1 ATOM 2156 C CG . HIS A 1 287 ? -3.566 -19.054 7.681 1.00 25.15 ? 314 HIS A CG 1 ATOM 2157 N ND1 . HIS A 1 287 ? -4.230 -20.107 8.262 1.00 26.94 ? 314 HIS A ND1 1 ATOM 2158 C CD2 . HIS A 1 287 ? -3.684 -18.020 8.537 1.00 27.21 ? 314 HIS A CD2 1 ATOM 2159 C CE1 . HIS A 1 287 ? -4.726 -19.739 9.422 1.00 25.95 ? 314 HIS A CE1 1 ATOM 2160 N NE2 . HIS A 1 287 ? -4.418 -18.471 9.609 1.00 28.18 ? 314 HIS A NE2 1 ATOM 2161 N N . ARG A 1 288 ? -4.730 -17.037 5.074 1.00 21.89 ? 315 ARG A N 1 ATOM 2162 C CA . ARG A 1 288 ? -5.762 -16.019 5.171 1.00 23.30 ? 315 ARG A CA 1 ATOM 2163 C C . ARG A 1 288 ? -6.930 -16.261 4.219 1.00 22.10 ? 315 ARG A C 1 ATOM 2164 O O . ARG A 1 288 ? -8.059 -15.959 4.551 1.00 22.98 ? 315 ARG A O 1 ATOM 2165 C CB . ARG A 1 288 ? -5.168 -14.655 4.920 1.00 24.20 ? 315 ARG A CB 1 ATOM 2166 C CG . ARG A 1 288 ? -4.320 -14.169 6.061 1.00 25.19 ? 315 ARG A CG 1 ATOM 2167 C CD . ARG A 1 288 ? -3.412 -13.045 5.595 1.00 25.40 ? 315 ARG A CD 1 ATOM 2168 N NE . ARG A 1 288 ? -2.775 -12.417 6.737 1.00 26.55 ? 315 ARG A NE 1 ATOM 2169 C CZ . ARG A 1 288 ? -2.003 -11.339 6.663 1.00 28.56 ? 315 ARG A CZ 1 ATOM 2170 N NH1 . ARG A 1 288 ? -1.700 -10.794 5.483 1.00 28.59 ? 315 ARG A NH1 1 ATOM 2171 N NH2 . ARG A 1 288 ? -1.509 -10.824 7.776 1.00 29.64 ? 315 ARG A NH2 1 ATOM 2172 N N . ILE A 1 289 ? -6.654 -16.801 3.042 1.00 22.06 ? 316 ILE A N 1 ATOM 2173 C CA . ILE A 1 289 ? -7.698 -17.151 2.078 1.00 21.94 ? 316 ILE A CA 1 ATOM 2174 C C . ILE A 1 289 ? -8.639 -18.210 2.676 1.00 23.09 ? 316 ILE A C 1 ATOM 2175 O O . ILE A 1 289 ? -9.882 -18.047 2.662 1.00 25.14 ? 316 ILE A O 1 ATOM 2176 C CB . ILE A 1 289 ? -7.088 -17.583 0.747 1.00 23.31 ? 316 ILE A CB 1 ATOM 2177 C CG1 . ILE A 1 289 ? -6.428 -16.368 0.062 1.00 24.24 ? 316 ILE A CG1 1 ATOM 2178 C CG2 . ILE A 1 289 ? -8.132 -18.216 -0.177 1.00 23.07 ? 316 ILE A CG2 1 ATOM 2179 C CD1 . ILE A 1 289 ? -5.604 -16.720 -1.164 1.00 24.77 ? 316 ILE A CD1 1 ATOM 2180 N N . VAL A 1 290 ? -8.066 -19.268 3.227 1.00 21.43 ? 317 VAL A N 1 ATOM 2181 C CA . VAL A 1 290 ? -8.872 -20.362 3.751 1.00 21.62 ? 317 VAL A CA 1 ATOM 2182 C C . VAL A 1 290 ? -9.779 -19.870 4.885 1.00 20.94 ? 317 VAL A C 1 ATOM 2183 O O . VAL A 1 290 ? -10.937 -20.248 4.959 1.00 22.58 ? 317 VAL A O 1 ATOM 2184 C CB . VAL A 1 290 ? -7.987 -21.559 4.164 1.00 21.61 ? 317 VAL A CB 1 ATOM 2185 C CG1 . VAL A 1 290 ? -8.788 -22.623 4.871 1.00 23.04 ? 317 VAL A CG1 1 ATOM 2186 C CG2 . VAL A 1 290 ? -7.344 -22.192 2.928 1.00 23.62 ? 317 VAL A CG2 1 ATOM 2187 N N . GLU A 1 291 ? -9.241 -19.028 5.763 1.00 21.45 ? 318 GLU A N 1 ATOM 2188 C CA . GLU A 1 291 ? -9.989 -18.467 6.883 1.00 21.62 ? 318 GLU A CA 1 ATOM 2189 C C . GLU A 1 291 ? -11.133 -17.563 6.402 1.00 21.80 ? 318 GLU A C 1 ATOM 2190 O O . GLU A 1 291 ? -12.212 -17.589 6.960 1.00 21.23 ? 318 GLU A O 1 ATOM 2191 C CB . GLU A 1 291 ? -9.049 -17.674 7.810 1.00 21.61 ? 318 GLU A CB 1 ATOM 2192 C CG . GLU A 1 291 ? -8.058 -18.528 8.609 1.00 22.18 ? 318 GLU A CG 1 ATOM 2193 C CD . GLU A 1 291 ? -8.738 -19.580 9.456 1.00 23.34 ? 318 GLU A CD 1 ATOM 2194 O OE1 . GLU A 1 291 ? -9.332 -19.263 10.530 1.00 23.84 ? 318 GLU A OE1 1 ATOM 2195 O OE2 . GLU A 1 291 ? -8.702 -20.743 9.031 1.00 26.33 ? 318 GLU A OE2 1 ATOM 2196 N N . ALA A 1 292 ? -10.885 -16.754 5.371 1.00 22.25 ? 319 ALA A N 1 ATOM 2197 C CA . ALA A 1 292 ? -11.950 -15.983 4.729 1.00 22.07 ? 319 ALA A CA 1 ATOM 2198 C C . ALA A 1 292 ? -13.040 -16.891 4.156 1.00 21.56 ? 319 ALA A C 1 ATOM 2199 O O . ALA A 1 292 ? -14.223 -16.602 4.290 1.00 23.51 ? 319 ALA A O 1 ATOM 2200 C CB . ALA A 1 292 ? -11.374 -15.072 3.661 1.00 22.57 ? 319 ALA A CB 1 ATOM 2201 N N . PHE A 1 293 ? -12.645 -18.001 3.548 1.00 21.25 ? 320 PHE A N 1 ATOM 2202 C CA . PHE A 1 293 ? -13.603 -19.001 3.090 1.00 20.60 ? 320 PHE A CA 1 ATOM 2203 C C . PHE A 1 293 ? -14.455 -19.492 4.278 1.00 22.18 ? 320 PHE A C 1 ATOM 2204 O O . PHE A 1 293 ? -15.688 -19.567 4.204 1.00 21.33 ? 320 PHE A O 1 ATOM 2205 C CB . PHE A 1 293 ? -12.902 -20.226 2.494 1.00 19.63 ? 320 PHE A CB 1 ATOM 2206 C CG . PHE A 1 293 ? -12.211 -20.016 1.170 1.00 19.00 ? 320 PHE A CG 1 ATOM 2207 C CD1 . PHE A 1 293 ? -12.404 -18.883 0.377 1.00 18.96 ? 320 PHE A CD1 1 ATOM 2208 C CD2 . PHE A 1 293 ? -11.430 -21.048 0.662 1.00 18.50 ? 320 PHE A CD2 1 ATOM 2209 C CE1 . PHE A 1 293 ? -11.773 -18.772 -0.840 1.00 18.32 ? 320 PHE A CE1 1 ATOM 2210 C CE2 . PHE A 1 293 ? -10.812 -20.942 -0.581 1.00 17.70 ? 320 PHE A CE2 1 ATOM 2211 C CZ . PHE A 1 293 ? -10.992 -19.803 -1.327 1.00 18.03 ? 320 PHE A CZ 1 ATOM 2212 N N . ARG A 1 294 ? -13.800 -19.818 5.387 1.00 23.25 ? 321 ARG A N 1 ATOM 2213 C CA . ARG A 1 294 ? -14.533 -20.325 6.529 1.00 23.96 ? 321 ARG A CA 1 ATOM 2214 C C . ARG A 1 294 ? -15.510 -19.300 7.118 1.00 25.17 ? 321 ARG A C 1 ATOM 2215 O O . ARG A 1 294 ? -16.668 -19.642 7.446 1.00 25.14 ? 321 ARG A O 1 ATOM 2216 C CB . ARG A 1 294 ? -13.560 -20.843 7.589 1.00 25.14 ? 321 ARG A CB 1 ATOM 2217 C CG . ARG A 1 294 ? -12.850 -22.115 7.114 1.00 24.91 ? 321 ARG A CG 1 ATOM 2218 C CD . ARG A 1 294 ? -11.634 -22.474 7.926 1.00 25.32 ? 321 ARG A CD 1 ATOM 2219 N NE . ARG A 1 294 ? -11.893 -23.003 9.263 1.00 27.03 ? 321 ARG A NE 1 ATOM 2220 C CZ . ARG A 1 294 ? -12.409 -24.197 9.540 1.00 27.59 ? 321 ARG A CZ 1 ATOM 2221 N NH1 . ARG A 1 294 ? -12.787 -25.021 8.580 1.00 29.97 ? 321 ARG A NH1 1 ATOM 2222 N NH2 . ARG A 1 294 ? -12.558 -24.574 10.805 1.00 30.12 ? 321 ARG A NH2 1 ATOM 2223 N N . PHE A 1 295 ? -15.068 -18.059 7.272 1.00 23.87 ? 322 PHE A N 1 ATOM 2224 C CA . PHE A 1 295 ? -15.969 -17.016 7.769 1.00 24.81 ? 322 PHE A CA 1 ATOM 2225 C C . PHE A 1 295 ? -17.147 -16.801 6.806 1.00 27.94 ? 322 PHE A C 1 ATOM 2226 O O . PHE A 1 295 ? -18.259 -16.540 7.259 1.00 30.70 ? 322 PHE A O 1 ATOM 2227 C CB . PHE A 1 295 ? -15.249 -15.679 7.994 1.00 24.34 ? 322 PHE A CB 1 ATOM 2228 C CG . PHE A 1 295 ? -14.704 -15.518 9.374 1.00 26.05 ? 322 PHE A CG 1 ATOM 2229 C CD1 . PHE A 1 295 ? -15.567 -15.358 10.447 1.00 25.99 ? 322 PHE A CD1 1 ATOM 2230 C CD2 . PHE A 1 295 ? -13.332 -15.584 9.617 1.00 25.76 ? 322 PHE A CD2 1 ATOM 2231 C CE1 . PHE A 1 295 ? -15.083 -15.252 11.736 1.00 25.63 ? 322 PHE A CE1 1 ATOM 2232 C CE2 . PHE A 1 295 ? -12.835 -15.467 10.901 1.00 26.21 ? 322 PHE A CE2 1 ATOM 2233 C CZ . PHE A 1 295 ? -13.707 -15.298 11.964 1.00 27.22 ? 322 PHE A CZ 1 ATOM 2234 N N . ALA A 1 296 ? -16.918 -16.896 5.495 1.00 28.20 ? 323 ALA A N 1 ATOM 2235 C CA . ALA A 1 296 ? -17.997 -16.644 4.531 1.00 29.89 ? 323 ALA A CA 1 ATOM 2236 C C . ALA A 1 296 ? -18.981 -17.803 4.482 1.00 30.36 ? 323 ALA A C 1 ATOM 2237 O O . ALA A 1 296 ? -20.173 -17.589 4.373 1.00 29.70 ? 323 ALA A O 1 ATOM 2238 C CB . ALA A 1 296 ? -17.435 -16.371 3.134 1.00 28.69 ? 323 ALA A CB 1 ATOM 2239 N N . TYR A 1 297 ? -18.484 -19.036 4.526 1.00 30.03 ? 324 TYR A N 1 ATOM 2240 C CA . TYR A 1 297 ? -19.376 -20.166 4.560 1.00 28.40 ? 324 TYR A CA 1 ATOM 2241 C C . TYR A 1 297 ? -20.195 -20.224 5.848 1.00 29.35 ? 324 TYR A C 1 ATOM 2242 O O . TYR A 1 297 ? -21.284 -20.770 5.846 1.00 31.66 ? 324 TYR A O 1 ATOM 2243 C CB . TYR A 1 297 ? -18.668 -21.468 4.236 1.00 30.01 ? 324 TYR A CB 1 ATOM 2244 C CG . TYR A 1 297 ? -18.562 -21.681 2.735 1.00 30.26 ? 324 TYR A CG 1 ATOM 2245 C CD1 . TYR A 1 297 ? -17.570 -21.061 1.996 1.00 29.62 ? 324 TYR A CD1 1 ATOM 2246 C CD2 . TYR A 1 297 ? -19.460 -22.502 2.054 1.00 31.55 ? 324 TYR A CD2 1 ATOM 2247 C CE1 . TYR A 1 297 ? -17.484 -21.228 0.622 1.00 31.03 ? 324 TYR A CE1 1 ATOM 2248 C CE2 . TYR A 1 297 ? -19.369 -22.694 0.676 1.00 30.75 ? 324 TYR A CE2 1 ATOM 2249 C CZ . TYR A 1 297 ? -18.379 -22.047 -0.044 1.00 32.43 ? 324 TYR A CZ 1 ATOM 2250 O OH . TYR A 1 297 ? -18.254 -22.206 -1.431 1.00 35.53 ? 324 TYR A OH 1 ATOM 2251 N N . ALA A 1 298 ? -19.742 -19.581 6.909 1.00 30.95 ? 325 ALA A N 1 ATOM 2252 C CA . ALA A 1 298 ? -20.484 -19.548 8.179 1.00 32.68 ? 325 ALA A CA 1 ATOM 2253 C C . ALA A 1 298 ? -21.850 -18.878 8.008 1.00 31.75 ? 325 ALA A C 1 ATOM 2254 O O . ALA A 1 298 ? -22.854 -19.264 8.621 1.00 26.85 ? 325 ALA A O 1 ATOM 2255 C CB . ALA A 1 298 ? -19.671 -18.793 9.241 1.00 33.83 ? 325 ALA A CB 1 ATOM 2256 N N . LYS A 1 299 ? -21.868 -17.858 7.172 1.00 30.49 ? 326 LYS A N 1 ATOM 2257 C CA . LYS A 1 299 ? -23.039 -17.034 7.019 1.00 33.14 ? 326 LYS A CA 1 ATOM 2258 C C . LYS A 1 299 ? -23.968 -17.587 5.918 1.00 33.22 ? 326 LYS A C 1 ATOM 2259 O O . LYS A 1 299 ? -25.151 -17.238 5.847 1.00 31.59 ? 326 LYS A O 1 ATOM 2260 C CB . LYS A 1 299 ? -22.543 -15.611 6.733 1.00 38.23 ? 326 LYS A CB 1 ATOM 2261 C CG . LYS A 1 299 ? -21.522 -15.113 7.772 1.00 41.11 ? 326 LYS A CG 1 ATOM 2262 C CD . LYS A 1 299 ? -22.166 -15.009 9.160 1.00 43.74 ? 326 LYS A CD 1 ATOM 2263 C CE . LYS A 1 299 ? -21.193 -15.183 10.331 1.00 49.48 ? 326 LYS A CE 1 ATOM 2264 N NZ . LYS A 1 299 ? -21.971 -15.441 11.594 1.00 48.89 ? 326 LYS A NZ 1 ATOM 2265 N N . ARG A 1 300 ? -23.417 -18.462 5.076 1.00 31.81 ? 327 ARG A N 1 ATOM 2266 C CA . ARG A 1 300 ? -24.122 -19.038 3.931 1.00 31.26 ? 327 ARG A CA 1 ATOM 2267 C C . ARG A 1 300 ? -25.374 -19.811 4.300 1.00 31.18 ? 327 ARG A C 1 ATOM 2268 O O . ARG A 1 300 ? -26.360 -19.783 3.561 1.00 31.02 ? 327 ARG A O 1 ATOM 2269 C CB . ARG A 1 300 ? -23.187 -19.971 3.188 1.00 29.29 ? 327 ARG A CB 1 ATOM 2270 C CG . ARG A 1 300 ? -23.752 -20.547 1.927 1.00 30.11 ? 327 ARG A CG 1 ATOM 2271 C CD . ARG A 1 300 ? -22.760 -21.534 1.343 1.00 34.03 ? 327 ARG A CD 1 ATOM 2272 N NE . ARG A 1 300 ? -23.109 -21.981 0.002 1.00 39.71 ? 327 ARG A NE 1 ATOM 2273 C CZ . ARG A 1 300 ? -23.898 -23.012 -0.277 1.00 42.69 ? 327 ARG A CZ 1 ATOM 2274 N NH1 . ARG A 1 300 ? -24.444 -23.713 0.701 1.00 43.45 ? 327 ARG A NH1 1 ATOM 2275 N NH2 . ARG A 1 300 ? -24.136 -23.349 -1.540 1.00 45.70 ? 327 ARG A NH2 1 ATOM 2276 N N . THR A 1 301 ? -25.340 -20.510 5.430 1.00 33.17 ? 328 THR A N 1 ATOM 2277 C CA . THR A 1 301 ? -26.502 -21.282 5.904 1.00 34.52 ? 328 THR A CA 1 ATOM 2278 C C . THR A 1 301 ? -27.762 -20.486 6.225 1.00 33.91 ? 328 THR A C 1 ATOM 2279 O O . THR A 1 301 ? -28.791 -21.092 6.499 1.00 34.92 ? 328 THR A O 1 ATOM 2280 C CB . THR A 1 301 ? -26.154 -22.077 7.177 1.00 38.13 ? 328 THR A CB 1 ATOM 2281 O OG1 . THR A 1 301 ? -25.353 -21.258 8.044 1.00 33.97 ? 328 THR A OG1 1 ATOM 2282 C CG2 . THR A 1 301 ? -25.420 -23.358 6.805 1.00 41.90 ? 328 THR A CG2 1 ATOM 2283 N N . LEU A 1 302 ? -27.697 -19.157 6.228 1.00 33.02 ? 329 LEU A N 1 ATOM 2284 C CA . LEU A 1 302 ? -28.925 -18.339 6.351 1.00 34.34 ? 329 LEU A CA 1 ATOM 2285 C C . LEU A 1 302 ? -29.555 -17.989 5.014 1.00 32.28 ? 329 LEU A C 1 ATOM 2286 O O . LEU A 1 302 ? -30.623 -17.388 4.976 1.00 32.14 ? 329 LEU A O 1 ATOM 2287 C CB . LEU A 1 302 ? -28.637 -17.028 7.096 1.00 35.09 ? 329 LEU A CB 1 ATOM 2288 C CG . LEU A 1 302 ? -28.257 -17.198 8.566 1.00 38.09 ? 329 LEU A CG 1 ATOM 2289 C CD1 . LEU A 1 302 ? -27.902 -15.867 9.206 1.00 39.37 ? 329 LEU A CD1 1 ATOM 2290 C CD2 . LEU A 1 302 ? -29.407 -17.863 9.309 1.00 39.74 ? 329 LEU A CD2 1 ATOM 2291 N N . LEU A 1 303 ? -28.888 -18.325 3.915 1.00 30.74 ? 330 LEU A N 1 ATOM 2292 C CA . LEU A 1 303 ? -29.372 -17.955 2.593 1.00 28.79 ? 330 LEU A CA 1 ATOM 2293 C C . LEU A 1 303 ? -30.416 -18.933 2.060 1.00 26.78 ? 330 LEU A C 1 ATOM 2294 O O . LEU A 1 303 ? -30.400 -20.118 2.373 1.00 25.36 ? 330 LEU A O 1 ATOM 2295 C CB . LEU A 1 303 ? -28.211 -17.852 1.597 1.00 29.56 ? 330 LEU A CB 1 ATOM 2296 C CG . LEU A 1 303 ? -27.215 -16.727 1.881 1.00 30.48 ? 330 LEU A CG 1 ATOM 2297 C CD1 . LEU A 1 303 ? -26.024 -16.811 0.947 1.00 30.76 ? 330 LEU A CD1 1 ATOM 2298 C CD2 . LEU A 1 303 ? -27.871 -15.376 1.725 1.00 30.36 ? 330 LEU A CD2 1 ATOM 2299 N N . GLY A 1 304 ? -31.322 -18.400 1.242 1.00 25.12 ? 331 GLY A N 1 ATOM 2300 C CA . GLY A 1 304 ? -32.323 -19.180 0.548 1.00 23.91 ? 331 GLY A CA 1 ATOM 2301 C C . GLY A 1 304 ? -33.011 -18.268 -0.446 1.00 24.00 ? 331 GLY A C 1 ATOM 2302 O O . GLY A 1 304 ? -32.633 -17.106 -0.596 1.00 23.51 ? 331 GLY A O 1 ATOM 2303 N N . ASP A 1 305 ? -34.001 -18.809 -1.138 1.00 23.37 ? 332 ASP A N 1 ATOM 2304 C CA . ASP A 1 305 ? -34.752 -18.061 -2.144 1.00 23.74 ? 332 ASP A CA 1 ATOM 2305 C C . ASP A 1 305 ? -35.401 -16.865 -1.467 1.00 24.63 ? 332 ASP A C 1 ATOM 2306 O O . ASP A 1 305 ? -36.214 -17.054 -0.555 1.00 26.05 ? 332 ASP A O 1 ATOM 2307 C CB . ASP A 1 305 ? -35.802 -18.998 -2.734 1.00 25.39 ? 332 ASP A CB 1 ATOM 2308 C CG . ASP A 1 305 ? -36.613 -18.382 -3.832 1.00 25.81 ? 332 ASP A CG 1 ATOM 2309 O OD1 . ASP A 1 305 ? -36.640 -17.145 -3.978 1.00 27.80 ? 332 ASP A OD1 1 ATOM 2310 O OD2 . ASP A 1 305 ? -37.259 -19.181 -4.550 1.00 27.76 ? 332 ASP A OD2 1 ATOM 2311 N N . PRO A 1 306 ? -35.043 -15.639 -1.890 1.00 25.36 ? 333 PRO A N 1 ATOM 2312 C CA . PRO A 1 306 ? -35.479 -14.420 -1.231 1.00 27.16 ? 333 PRO A CA 1 ATOM 2313 C C . PRO A 1 306 ? -36.954 -14.119 -1.389 1.00 29.22 ? 333 PRO A C 1 ATOM 2314 O O . PRO A 1 306 ? -37.496 -13.275 -0.657 1.00 31.41 ? 333 PRO A O 1 ATOM 2315 C CB . PRO A 1 306 ? -34.629 -13.315 -1.892 1.00 27.68 ? 333 PRO A CB 1 ATOM 2316 C CG . PRO A 1 306 ? -34.251 -13.884 -3.216 1.00 27.91 ? 333 PRO A CG 1 ATOM 2317 C CD . PRO A 1 306 ? -34.076 -15.354 -2.966 1.00 26.63 ? 333 PRO A CD 1 ATOM 2318 N N . LYS A 1 307 ? -37.603 -14.793 -2.320 1.00 30.77 ? 334 LYS A N 1 ATOM 2319 C CA . LYS A 1 307 ? -39.051 -14.703 -2.420 1.00 32.41 ? 334 LYS A CA 1 ATOM 2320 C C . LYS A 1 307 ? -39.757 -15.513 -1.353 1.00 31.46 ? 334 LYS A C 1 ATOM 2321 O O . LYS A 1 307 ? -40.931 -15.304 -1.117 1.00 33.01 ? 334 LYS A O 1 ATOM 2322 C CB . LYS A 1 307 ? -39.521 -15.209 -3.767 1.00 33.90 ? 334 LYS A CB 1 ATOM 2323 C CG . LYS A 1 307 ? -38.996 -14.445 -4.961 1.00 34.33 ? 334 LYS A CG 1 ATOM 2324 C CD . LYS A 1 307 ? -39.683 -15.010 -6.196 1.00 39.32 ? 334 LYS A CD 1 ATOM 2325 C CE . LYS A 1 307 ? -38.929 -14.731 -7.473 1.00 43.57 ? 334 LYS A CE 1 ATOM 2326 N NZ . LYS A 1 307 ? -38.803 -13.263 -7.684 1.00 49.26 ? 334 LYS A NZ 1 ATOM 2327 N N . PHE A 1 308 ? -39.062 -16.457 -0.739 1.00 31.81 ? 335 PHE A N 1 ATOM 2328 C CA . PHE A 1 308 ? -39.630 -17.291 0.328 1.00 33.51 ? 335 PHE A CA 1 ATOM 2329 C C . PHE A 1 308 ? -39.038 -17.032 1.720 1.00 36.03 ? 335 PHE A C 1 ATOM 2330 O O . PHE A 1 308 ? -39.614 -17.433 2.709 1.00 36.81 ? 335 PHE A O 1 ATOM 2331 C CB . PHE A 1 308 ? -39.442 -18.774 -0.028 1.00 33.47 ? 335 PHE A CB 1 ATOM 2332 C CG . PHE A 1 308 ? -40.384 -19.249 -1.089 1.00 33.23 ? 335 PHE A CG 1 ATOM 2333 C CD1 . PHE A 1 308 ? -40.199 -18.879 -2.418 1.00 30.57 ? 335 PHE A CD1 1 ATOM 2334 C CD2 . PHE A 1 308 ? -41.491 -20.032 -0.755 1.00 32.61 ? 335 PHE A CD2 1 ATOM 2335 C CE1 . PHE A 1 308 ? -41.087 -19.285 -3.398 1.00 31.36 ? 335 PHE A CE1 1 ATOM 2336 C CE2 . PHE A 1 308 ? -42.379 -20.459 -1.740 1.00 31.33 ? 335 PHE A CE2 1 ATOM 2337 C CZ . PHE A 1 308 ? -42.173 -20.086 -3.067 1.00 32.16 ? 335 PHE A CZ 1 ATOM 2338 N N . VAL A 1 309 ? -37.881 -16.391 1.790 1.00 37.54 ? 336 VAL A N 1 ATOM 2339 C CA . VAL A 1 309 ? -37.164 -16.229 3.046 1.00 37.86 ? 336 VAL A CA 1 ATOM 2340 C C . VAL A 1 309 ? -36.609 -14.829 3.017 1.00 36.06 ? 336 VAL A C 1 ATOM 2341 O O . VAL A 1 309 ? -36.105 -14.394 2.000 1.00 34.16 ? 336 VAL A O 1 ATOM 2342 C CB . VAL A 1 309 ? -36.000 -17.240 3.163 1.00 41.48 ? 336 VAL A CB 1 ATOM 2343 C CG1 . VAL A 1 309 ? -35.155 -16.948 4.395 1.00 45.55 ? 336 VAL A CG1 1 ATOM 2344 C CG2 . VAL A 1 309 ? -36.549 -18.647 3.216 1.00 43.36 ? 336 VAL A CG2 1 ATOM 2345 N N . ASP A 1 310 ? -36.683 -14.126 4.133 1.00 37.65 ? 337 ASP A N 1 ATOM 2346 C CA . ASP A 1 310 ? -36.220 -12.758 4.181 1.00 40.01 ? 337 ASP A CA 1 ATOM 2347 C C . ASP A 1 310 ? -34.713 -12.808 4.413 1.00 37.88 ? 337 ASP A C 1 ATOM 2348 O O . ASP A 1 310 ? -34.267 -13.195 5.486 1.00 37.17 ? 337 ASP A O 1 ATOM 2349 C CB . ASP A 1 310 ? -36.930 -12.015 5.307 1.00 43.67 ? 337 ASP A CB 1 ATOM 2350 C CG . ASP A 1 310 ? -36.518 -10.546 5.409 1.00 48.41 ? 337 ASP A CG 1 ATOM 2351 O OD1 . ASP A 1 310 ? -35.742 -10.027 4.564 1.00 49.66 ? 337 ASP A OD1 1 ATOM 2352 O OD2 . ASP A 1 310 ? -36.996 -9.902 6.363 1.00 57.23 ? 337 ASP A OD2 1 ATOM 2353 N N . VAL A 1 311 ? -33.939 -12.456 3.392 1.00 36.18 ? 338 VAL A N 1 ATOM 2354 C CA . VAL A 1 311 ? -32.466 -12.520 3.479 1.00 36.71 ? 338 VAL A CA 1 ATOM 2355 C C . VAL A 1 311 ? -31.848 -11.145 3.368 1.00 34.82 ? 338 VAL A C 1 ATOM 2356 O O . VAL A 1 311 ? -30.632 -11.023 3.225 1.00 33.90 ? 338 VAL A O 1 ATOM 2357 C CB . VAL A 1 311 ? -31.866 -13.397 2.362 1.00 35.20 ? 338 VAL A CB 1 ATOM 2358 C CG1 . VAL A 1 311 ? -32.303 -14.821 2.552 1.00 35.63 ? 338 VAL A CG1 1 ATOM 2359 C CG2 . VAL A 1 311 ? -32.252 -12.871 0.988 1.00 34.11 ? 338 VAL A CG2 1 ATOM 2360 N N . THR A 1 312 ? -32.701 -10.130 3.444 1.00 34.60 ? 339 THR A N 1 ATOM 2361 C CA . THR A 1 312 ? -32.347 -8.738 3.167 1.00 38.17 ? 339 THR A CA 1 ATOM 2362 C C . THR A 1 312 ? -31.168 -8.261 4.026 1.00 38.03 ? 339 THR A C 1 ATOM 2363 O O . THR A 1 312 ? -30.214 -7.653 3.504 1.00 35.55 ? 339 THR A O 1 ATOM 2364 C CB . THR A 1 312 ? -33.592 -7.827 3.393 1.00 41.67 ? 339 THR A CB 1 ATOM 2365 O OG1 . THR A 1 312 ? -34.614 -8.178 2.451 1.00 42.05 ? 339 THR A OG1 1 ATOM 2366 C CG2 . THR A 1 312 ? -33.254 -6.381 3.180 1.00 43.96 ? 339 THR A CG2 1 ATOM 2367 N N . GLU A 1 313 ? -31.229 -8.562 5.320 1.00 38.18 ? 340 GLU A N 1 ATOM 2368 C CA . GLU A 1 313 ? -30.191 -8.118 6.263 1.00 45.03 ? 340 GLU A CA 1 ATOM 2369 C C . GLU A 1 313 ? -28.985 -9.017 6.210 1.00 38.04 ? 340 GLU A C 1 ATOM 2370 O O . GLU A 1 313 ? -27.879 -8.537 6.286 1.00 39.01 ? 340 GLU A O 1 ATOM 2371 C CB . GLU A 1 313 ? -30.689 -8.071 7.711 1.00 48.94 ? 340 GLU A CB 1 ATOM 2372 C CG . GLU A 1 313 ? -31.874 -7.149 7.939 1.00 58.52 ? 340 GLU A CG 1 ATOM 2373 C CD . GLU A 1 313 ? -31.630 -5.724 7.459 1.00 68.32 ? 340 GLU A CD 1 ATOM 2374 O OE1 . GLU A 1 313 ? -32.579 -5.127 6.886 1.00 75.17 ? 340 GLU A OE1 1 ATOM 2375 O OE2 . GLU A 1 313 ? -30.499 -5.197 7.629 1.00 71.47 ? 340 GLU A OE2 1 ATOM 2376 N N . VAL A 1 314 ? -29.201 -10.319 6.089 1.00 35.52 ? 341 VAL A N 1 ATOM 2377 C CA . VAL A 1 314 ? -28.086 -11.245 5.889 1.00 34.65 ? 341 VAL A CA 1 ATOM 2378 C C . VAL A 1 314 ? -27.234 -10.794 4.701 1.00 31.19 ? 341 VAL A C 1 ATOM 2379 O O . VAL A 1 314 ? -25.996 -10.704 4.811 1.00 27.99 ? 341 VAL A O 1 ATOM 2380 C CB . VAL A 1 314 ? -28.560 -12.679 5.665 1.00 36.42 ? 341 VAL A CB 1 ATOM 2381 C CG1 . VAL A 1 314 ? -27.396 -13.582 5.283 1.00 37.65 ? 341 VAL A CG1 1 ATOM 2382 C CG2 . VAL A 1 314 ? -29.244 -13.202 6.926 1.00 40.48 ? 341 VAL A CG2 1 ATOM 2383 N N . VAL A 1 315 ? -27.900 -10.495 3.588 1.00 29.74 ? 342 VAL A N 1 ATOM 2384 C CA . VAL A 1 315 ? -27.208 -10.152 2.351 1.00 29.72 ? 342 VAL A CA 1 ATOM 2385 C C . VAL A 1 315 ? -26.517 -8.800 2.512 1.00 32.04 ? 342 VAL A C 1 ATOM 2386 O O . VAL A 1 315 ? -25.388 -8.611 2.029 1.00 31.80 ? 342 VAL A O 1 ATOM 2387 C CB . VAL A 1 315 ? -28.162 -10.144 1.141 1.00 30.31 ? 342 VAL A CB 1 ATOM 2388 C CG1 . VAL A 1 315 ? -27.496 -9.507 -0.078 1.00 30.23 ? 342 VAL A CG1 1 ATOM 2389 C CG2 . VAL A 1 315 ? -28.627 -11.558 0.817 1.00 30.33 ? 342 VAL A CG2 1 ATOM 2390 N N . ARG A 1 316 ? -27.177 -7.886 3.199 1.00 33.85 ? 343 ARG A N 1 ATOM 2391 C CA . ARG A 1 316 ? -26.655 -6.589 3.530 1.00 36.87 ? 343 ARG A CA 1 ATOM 2392 C C . ARG A 1 316 ? -25.321 -6.737 4.271 1.00 32.07 ? 343 ARG A C 1 ATOM 2393 O O . ARG A 1 316 ? -24.359 -6.127 3.925 1.00 29.95 ? 343 ARG A O 1 ATOM 2394 C CB . ARG A 1 316 ? -27.703 -5.794 4.334 1.00 45.48 ? 343 ARG A CB 1 ATOM 2395 C CG . ARG A 1 316 ? -27.331 -4.391 4.777 1.00 54.58 ? 343 ARG A CG 1 ATOM 2396 C CD . ARG A 1 316 ? -28.399 -3.641 5.627 1.00 64.61 ? 343 ARG A CD 1 ATOM 2397 N NE . ARG A 1 316 ? -29.191 -2.627 4.927 1.00 70.38 ? 343 ARG A NE 1 ATOM 2398 C CZ . ARG A 1 316 ? -30.412 -2.831 4.464 1.00 77.46 ? 343 ARG A CZ 1 ATOM 2399 N NH1 . ARG A 1 316 ? -30.985 -4.000 4.666 1.00 78.86 ? 343 ARG A NH1 1 ATOM 2400 N NH2 . ARG A 1 316 ? -31.056 -1.879 3.808 1.00 77.36 ? 343 ARG A NH2 1 ATOM 2401 N N . ASN A 1 317 ? -25.283 -7.583 5.266 1.00 29.71 ? 344 ASN A N 1 ATOM 2402 C CA . ASN A 1 317 ? -24.049 -7.864 5.993 1.00 30.66 ? 344 ASN A CA 1 ATOM 2403 C C . ASN A 1 317 ? -22.964 -8.502 5.147 1.00 30.71 ? 344 ASN A C 1 ATOM 2404 O O . ASN A 1 317 ? -21.801 -8.059 5.160 1.00 29.33 ? 344 ASN A O 1 ATOM 2405 C CB . ASN A 1 317 ? -24.359 -8.758 7.167 1.00 35.20 ? 344 ASN A CB 1 ATOM 2406 C CG . ASN A 1 317 ? -24.757 -7.970 8.383 1.00 39.52 ? 344 ASN A CG 1 ATOM 2407 O OD1 . ASN A 1 317 ? -24.808 -6.742 8.345 1.00 39.41 ? 344 ASN A OD1 1 ATOM 2408 N ND2 . ASN A 1 317 ? -25.023 -8.668 9.483 1.00 46.24 ? 344 ASN A ND2 1 ATOM 2409 N N . MET A 1 318 ? -23.362 -9.514 4.369 1.00 29.55 ? 345 MET A N 1 ATOM 2410 C CA . MET A 1 318 ? -22.414 -10.273 3.568 1.00 28.11 ? 345 MET A CA 1 ATOM 2411 C C . MET A 1 318 ? -21.756 -9.416 2.489 1.00 26.09 ? 345 MET A C 1 ATOM 2412 O O . MET A 1 318 ? -20.634 -9.708 2.095 1.00 26.11 ? 345 MET A O 1 ATOM 2413 C CB . MET A 1 318 ? -23.068 -11.541 2.991 1.00 29.16 ? 345 MET A CB 1 ATOM 2414 C CG . MET A 1 318 ? -23.381 -12.585 4.052 1.00 28.25 ? 345 MET A CG 1 ATOM 2415 S SD . MET A 1 318 ? -24.156 -14.070 3.385 1.00 30.39 ? 345 MET A SD 1 ATOM 2416 C CE . MET A 1 318 ? -22.742 -14.928 2.764 1.00 28.99 ? 345 MET A CE 1 ATOM 2417 N N . THR A 1 319 ? -22.412 -8.338 2.066 1.00 25.93 ? 346 THR A N 1 ATOM 2418 C CA . THR A 1 319 ? -21.841 -7.390 1.101 1.00 27.00 ? 346 THR A CA 1 ATOM 2419 C C . THR A 1 319 ? -21.264 -6.120 1.749 1.00 28.01 ? 346 THR A C 1 ATOM 2420 O O . THR A 1 319 ? -20.780 -5.270 1.052 1.00 28.54 ? 346 THR A O 1 ATOM 2421 C CB . THR A 1 319 ? -22.891 -6.939 0.071 1.00 29.56 ? 346 THR A CB 1 ATOM 2422 O OG1 . THR A 1 319 ? -24.012 -6.366 0.765 1.00 33.06 ? 346 THR A OG1 1 ATOM 2423 C CG2 . THR A 1 319 ? -23.382 -8.120 -0.739 1.00 29.22 ? 346 THR A CG2 1 ATOM 2424 N N . SER A 1 320 ? -21.281 -6.007 3.076 1.00 28.28 ? 347 SER A N 1 ATOM 2425 C CA . SER A 1 320 ? -20.768 -4.808 3.745 1.00 26.96 ? 347 SER A CA 1 ATOM 2426 C C . SER A 1 320 ? -19.291 -4.956 4.026 1.00 27.89 ? 347 SER A C 1 ATOM 2427 O O . SER A 1 320 ? -18.871 -5.954 4.620 1.00 25.94 ? 347 SER A O 1 ATOM 2428 C CB . SER A 1 320 ? -21.511 -4.582 5.066 1.00 26.34 ? 347 SER A CB 1 ATOM 2429 O OG . SER A 1 320 ? -20.702 -3.889 5.998 1.00 29.38 ? 347 SER A OG 1 ATOM 2430 N N . GLU A 1 321 ? -18.514 -3.936 3.661 1.00 28.77 ? 348 GLU A N 1 ATOM 2431 C CA . GLU A 1 321 ? -17.074 -3.924 3.899 1.00 29.64 ? 348 GLU A CA 1 ATOM 2432 C C . GLU A 1 321 ? -16.759 -3.841 5.347 1.00 27.47 ? 348 GLU A C 1 ATOM 2433 O O . GLU A 1 321 ? -15.742 -4.348 5.790 1.00 25.59 ? 348 GLU A O 1 ATOM 2434 C CB . GLU A 1 321 ? -16.408 -2.715 3.222 1.00 32.75 ? 348 GLU A CB 1 ATOM 2435 C CG . GLU A 1 321 ? -16.448 -2.772 1.714 1.00 36.95 ? 348 GLU A CG 1 ATOM 2436 C CD . GLU A 1 321 ? -16.262 -1.414 1.057 1.00 39.44 ? 348 GLU A CD 1 ATOM 2437 O OE1 . GLU A 1 321 ? -17.097 -0.498 1.296 1.00 47.83 ? 348 GLU A OE1 1 ATOM 2438 O OE2 . GLU A 1 321 ? -15.279 -1.289 0.296 1.00 46.97 ? 348 GLU A OE2 1 ATOM 2439 N N . PHE A 1 322 ? -17.602 -3.131 6.091 1.00 29.18 ? 349 PHE A N 1 ATOM 2440 C CA . PHE A 1 322 ? -17.395 -2.997 7.518 1.00 27.51 ? 349 PHE A CA 1 ATOM 2441 C C . PHE A 1 322 ? -17.497 -4.351 8.239 1.00 26.28 ? 349 PHE A C 1 ATOM 2442 O O . PHE A 1 322 ? -16.621 -4.736 8.991 1.00 27.05 ? 349 PHE A O 1 ATOM 2443 C CB . PHE A 1 322 ? -18.419 -2.015 8.089 1.00 27.49 ? 349 PHE A CB 1 ATOM 2444 C CG . PHE A 1 322 ? -18.215 -1.745 9.536 1.00 26.51 ? 349 PHE A CG 1 ATOM 2445 C CD1 . PHE A 1 322 ? -17.035 -1.194 9.969 1.00 26.59 ? 349 PHE A CD1 1 ATOM 2446 C CD2 . PHE A 1 322 ? -19.189 -2.068 10.456 1.00 27.28 ? 349 PHE A CD2 1 ATOM 2447 C CE1 . PHE A 1 322 ? -16.828 -0.946 11.311 1.00 28.17 ? 349 PHE A CE1 1 ATOM 2448 C CE2 . PHE A 1 322 ? -19.005 -1.827 11.796 1.00 26.46 ? 349 PHE A CE2 1 ATOM 2449 C CZ . PHE A 1 322 ? -17.815 -1.261 12.220 1.00 28.48 ? 349 PHE A CZ 1 ATOM 2450 N N . PHE A 1 323 ? -18.572 -5.067 7.968 1.00 26.56 ? 350 PHE A N 1 ATOM 2451 C CA . PHE A 1 323 ? -18.786 -6.408 8.473 1.00 27.11 ? 350 PHE A CA 1 ATOM 2452 C C . PHE A 1 323 ? -17.636 -7.326 8.069 1.00 25.90 ? 350 PHE A C 1 ATOM 2453 O O . PHE A 1 323 ? -17.136 -8.098 8.862 1.00 26.09 ? 350 PHE A O 1 ATOM 2454 C CB . PHE A 1 323 ? -20.093 -6.926 7.892 1.00 29.34 ? 350 PHE A CB 1 ATOM 2455 C CG . PHE A 1 323 ? -20.494 -8.275 8.394 1.00 32.46 ? 350 PHE A CG 1 ATOM 2456 C CD1 . PHE A 1 323 ? -21.018 -8.426 9.678 1.00 36.01 ? 350 PHE A CD1 1 ATOM 2457 C CD2 . PHE A 1 323 ? -20.376 -9.395 7.583 1.00 30.64 ? 350 PHE A CD2 1 ATOM 2458 C CE1 . PHE A 1 323 ? -21.418 -9.679 10.134 1.00 35.62 ? 350 PHE A CE1 1 ATOM 2459 C CE2 . PHE A 1 323 ? -20.778 -10.641 8.033 1.00 30.56 ? 350 PHE A CE2 1 ATOM 2460 C CZ . PHE A 1 323 ? -21.294 -10.785 9.298 1.00 32.73 ? 350 PHE A CZ 1 ATOM 2461 N N . ALA A 1 324 ? -17.187 -7.209 6.833 1.00 25.35 ? 351 ALA A N 1 ATOM 2462 C CA . ALA A 1 324 ? -16.104 -8.044 6.372 1.00 26.07 ? 351 ALA A CA 1 ATOM 2463 C C . ALA A 1 324 ? -14.858 -7.717 7.160 1.00 26.38 ? 351 ALA A C 1 ATOM 2464 O O . ALA A 1 324 ? -14.093 -8.621 7.484 1.00 26.43 ? 351 ALA A O 1 ATOM 2465 C CB . ALA A 1 324 ? -15.867 -7.873 4.883 1.00 26.11 ? 351 ALA A CB 1 ATOM 2466 N N . ALA A 1 325 ? -14.666 -6.439 7.486 1.00 25.57 ? 352 ALA A N 1 ATOM 2467 C CA . ALA A 1 325 ? -13.521 -6.023 8.294 1.00 23.93 ? 352 ALA A CA 1 ATOM 2468 C C . ALA A 1 325 ? -13.589 -6.569 9.707 1.00 25.36 ? 352 ALA A C 1 ATOM 2469 O O . ALA A 1 325 ? -12.562 -6.886 10.291 1.00 26.84 ? 352 ALA A O 1 ATOM 2470 C CB . ALA A 1 325 ? -13.414 -4.527 8.356 1.00 25.01 ? 352 ALA A CB 1 ATOM 2471 N N . GLN A 1 326 ? -14.791 -6.651 10.256 1.00 25.46 ? 353 GLN A N 1 ATOM 2472 C CA . GLN A 1 326 ? -14.996 -7.282 11.558 1.00 26.39 ? 353 GLN A CA 1 ATOM 2473 C C . GLN A 1 326 ? -14.559 -8.746 11.565 1.00 25.25 ? 353 GLN A C 1 ATOM 2474 O O . GLN A 1 326 ? -13.911 -9.197 12.496 1.00 24.62 ? 353 GLN A O 1 ATOM 2475 C CB . GLN A 1 326 ? -16.457 -7.148 11.976 1.00 28.72 ? 353 GLN A CB 1 ATOM 2476 C CG . GLN A 1 326 ? -16.887 -5.708 12.196 1.00 30.93 ? 353 GLN A CG 1 ATOM 2477 C CD . GLN A 1 326 ? -18.300 -5.589 12.729 1.00 32.94 ? 353 GLN A CD 1 ATOM 2478 O OE1 . GLN A 1 326 ? -19.243 -6.126 12.166 1.00 31.33 ? 353 GLN A OE1 1 ATOM 2479 N NE2 . GLN A 1 326 ? -18.443 -4.871 13.828 1.00 34.70 ? 353 GLN A NE2 1 ATOM 2480 N N . LEU A 1 327 ? -14.913 -9.472 10.504 1.00 25.84 ? 354 LEU A N 1 ATOM 2481 C CA . LEU A 1 327 ? -14.502 -10.845 10.326 1.00 24.83 ? 354 LEU A CA 1 ATOM 2482 C C . LEU A 1 327 ? -13.002 -10.950 10.090 1.00 24.94 ? 354 LEU A C 1 ATOM 2483 O O . LEU A 1 327 ? -12.336 -11.763 10.727 1.00 26.46 ? 354 LEU A O 1 ATOM 2484 C CB . LEU A 1 327 ? -15.297 -11.487 9.185 1.00 24.85 ? 354 LEU A CB 1 ATOM 2485 C CG . LEU A 1 327 ? -16.820 -11.442 9.385 1.00 25.92 ? 354 LEU A CG 1 ATOM 2486 C CD1 . LEU A 1 327 ? -17.517 -12.403 8.425 1.00 26.28 ? 354 LEU A CD1 1 ATOM 2487 C CD2 . LEU A 1 327 ? -17.237 -11.789 10.798 1.00 25.35 ? 354 LEU A CD2 1 ATOM 2488 N N . ARG A 1 328 ? -12.445 -10.114 9.219 1.00 25.04 ? 355 ARG A N 1 ATOM 2489 C CA . ARG A 1 328 ? -10.991 -10.140 9.027 1.00 27.05 ? 355 ARG A CA 1 ATOM 2490 C C . ARG A 1 328 ? -10.180 -9.945 10.305 1.00 25.79 ? 355 ARG A C 1 ATOM 2491 O O . ARG A 1 328 ? -9.124 -10.551 10.445 1.00 24.84 ? 355 ARG A O 1 ATOM 2492 C CB . ARG A 1 328 ? -10.489 -9.109 8.003 1.00 29.30 ? 355 ARG A CB 1 ATOM 2493 C CG . ARG A 1 328 ? -9.141 -9.545 7.412 1.00 32.49 ? 355 ARG A CG 1 ATOM 2494 C CD . ARG A 1 328 ? -8.233 -8.404 7.004 1.00 36.65 ? 355 ARG A CD 1 ATOM 2495 N NE . ARG A 1 328 ? -9.048 -7.252 6.725 1.00 42.23 ? 355 ARG A NE 1 ATOM 2496 C CZ . ARG A 1 328 ? -9.016 -6.103 7.389 1.00 42.15 ? 355 ARG A CZ 1 ATOM 2497 N NH1 . ARG A 1 328 ? -8.127 -5.868 8.369 1.00 42.82 ? 355 ARG A NH1 1 ATOM 2498 N NH2 . ARG A 1 328 ? -9.885 -5.173 7.025 1.00 41.95 ? 355 ARG A NH2 1 ATOM 2499 N N . ALA A 1 329 ? -10.670 -9.113 11.229 1.00 25.38 ? 356 ALA A N 1 ATOM 2500 C CA . ALA A 1 329 ? -9.953 -8.843 12.473 1.00 26.93 ? 356 ALA A CA 1 ATOM 2501 C C . ALA A 1 329 ? -9.969 -10.070 13.362 1.00 27.43 ? 356 ALA A C 1 ATOM 2502 O O . ALA A 1 329 ? -9.167 -10.155 14.283 1.00 26.48 ? 356 ALA A O 1 ATOM 2503 C CB . ALA A 1 329 ? -10.580 -7.655 13.220 1.00 29.79 ? 356 ALA A CB 1 ATOM 2504 N N . GLN A 1 330 ? -10.883 -11.013 13.105 1.00 26.20 ? 357 GLN A N 1 ATOM 2505 C CA . GLN A 1 330 ? -10.896 -12.253 13.874 1.00 27.22 ? 357 GLN A CA 1 ATOM 2506 C C . GLN A 1 330 ? -10.052 -13.362 13.241 1.00 26.04 ? 357 GLN A C 1 ATOM 2507 O O . GLN A 1 330 ? -9.904 -14.444 13.819 1.00 25.47 ? 357 GLN A O 1 ATOM 2508 C CB . GLN A 1 330 ? -12.323 -12.740 14.091 1.00 29.24 ? 357 GLN A CB 1 ATOM 2509 C CG . GLN A 1 330 ? -13.167 -11.796 14.904 1.00 29.31 ? 357 GLN A CG 1 ATOM 2510 C CD . GLN A 1 330 ? -14.616 -12.228 14.867 1.00 32.36 ? 357 GLN A CD 1 ATOM 2511 O OE1 . GLN A 1 330 ? -14.986 -13.257 15.432 1.00 31.76 ? 357 GLN A OE1 1 ATOM 2512 N NE2 . GLN A 1 330 ? -15.444 -11.448 14.181 1.00 33.43 ? 357 GLN A NE2 1 ATOM 2513 N N . ILE A 1 331 ? -9.454 -13.091 12.091 1.00 25.96 ? 358 ILE A N 1 ATOM 2514 C CA . ILE A 1 331 ? -8.556 -14.072 11.490 1.00 26.61 ? 358 ILE A CA 1 ATOM 2515 C C . ILE A 1 331 ? -7.191 -14.024 12.170 1.00 26.82 ? 358 ILE A C 1 ATOM 2516 O O . ILE A 1 331 ? -6.489 -13.033 12.081 1.00 27.75 ? 358 ILE A O 1 ATOM 2517 C CB . ILE A 1 331 ? -8.420 -13.835 9.986 1.00 26.91 ? 358 ILE A CB 1 ATOM 2518 C CG1 . ILE A 1 331 ? -9.758 -14.127 9.323 1.00 26.78 ? 358 ILE A CG1 1 ATOM 2519 C CG2 . ILE A 1 331 ? -7.332 -14.716 9.377 1.00 27.74 ? 358 ILE A CG2 1 ATOM 2520 C CD1 . ILE A 1 331 ? -9.807 -13.735 7.870 1.00 28.50 ? 358 ILE A CD1 1 ATOM 2521 N N . SER A 1 332 ? -6.827 -15.106 12.841 1.00 27.38 ? 359 SER A N 1 ATOM 2522 C CA . SER A 1 332 ? -5.503 -15.243 13.445 1.00 27.97 ? 359 SER A CA 1 ATOM 2523 C C . SER A 1 332 ? -4.486 -15.686 12.420 1.00 28.74 ? 359 SER A C 1 ATOM 2524 O O . SER A 1 332 ? -4.675 -16.683 11.722 1.00 28.97 ? 359 SER A O 1 ATOM 2525 C CB . SER A 1 332 ? -5.536 -16.283 14.551 1.00 27.34 ? 359 SER A CB 1 ATOM 2526 O OG . SER A 1 332 ? -6.620 -16.028 15.429 1.00 29.12 ? 359 SER A OG 1 ATOM 2527 N N . ASP A 1 333 ? -3.378 -14.967 12.364 1.00 30.09 ? 360 ASP A N 1 ATOM 2528 C CA . ASP A 1 333 ? -2.353 -15.246 11.386 1.00 29.57 ? 360 ASP A CA 1 ATOM 2529 C C . ASP A 1 333 ? -1.592 -16.541 11.642 1.00 30.88 ? 360 ASP A C 1 ATOM 2530 O O . ASP A 1 333 ? -1.008 -17.103 10.715 1.00 29.36 ? 360 ASP A O 1 ATOM 2531 C CB . ASP A 1 333 ? -1.401 -14.056 11.292 1.00 30.25 ? 360 ASP A CB 1 ATOM 2532 C CG . ASP A 1 333 ? -1.954 -12.950 10.417 1.00 31.20 ? 360 ASP A CG 1 ATOM 2533 O OD1 . ASP A 1 333 ? -2.920 -13.200 9.669 1.00 34.37 ? 360 ASP A OD1 1 ATOM 2534 O OD2 . ASP A 1 333 ? -1.423 -11.827 10.448 1.00 33.40 ? 360 ASP A OD2 1 ATOM 2535 N N . ASP A 1 334 ? -1.600 -17.012 12.888 1.00 32.37 ? 361 ASP A N 1 ATOM 2536 C CA . ASP A 1 334 ? -0.857 -18.220 13.302 1.00 33.80 ? 361 ASP A CA 1 ATOM 2537 C C . ASP A 1 334 ? -1.717 -19.487 13.469 1.00 32.08 ? 361 ASP A C 1 ATOM 2538 O O . ASP A 1 334 ? -1.180 -20.551 13.760 1.00 32.10 ? 361 ASP A O 1 ATOM 2539 C CB . ASP A 1 334 ? -0.171 -17.952 14.656 1.00 39.05 ? 361 ASP A CB 1 ATOM 2540 C CG . ASP A 1 334 ? -1.189 -17.617 15.766 1.00 44.33 ? 361 ASP A CG 1 ATOM 2541 O OD1 . ASP A 1 334 ? -1.956 -16.649 15.604 1.00 46.55 ? 361 ASP A OD1 1 ATOM 2542 O OD2 . ASP A 1 334 ? -1.246 -18.325 16.782 1.00 55.15 ? 361 ASP A OD2 1 ATOM 2543 N N . THR A 1 335 ? -3.041 -19.404 13.342 1.00 30.18 ? 362 THR A N 1 ATOM 2544 C CA . THR A 1 335 ? -3.857 -20.611 13.547 1.00 28.50 ? 362 THR A CA 1 ATOM 2545 C C . THR A 1 335 ? -5.246 -20.521 12.926 1.00 28.70 ? 362 THR A C 1 ATOM 2546 O O . THR A 1 335 ? -5.819 -19.435 12.811 1.00 29.27 ? 362 THR A O 1 ATOM 2547 C CB . THR A 1 335 ? -3.965 -20.965 15.059 1.00 29.99 ? 362 THR A CB 1 ATOM 2548 O OG1 . THR A 1 335 ? -4.584 -22.239 15.222 1.00 30.02 ? 362 THR A OG1 1 ATOM 2549 C CG2 . THR A 1 335 ? -4.772 -19.917 15.871 1.00 29.11 ? 362 THR A CG2 1 ATOM 2550 N N . THR A 1 336 ? -5.751 -21.669 12.479 1.00 27.95 ? 363 THR A N 1 ATOM 2551 C CA . THR A 1 336 ? -7.158 -21.818 12.171 1.00 27.14 ? 363 THR A CA 1 ATOM 2552 C C . THR A 1 336 ? -7.878 -22.124 13.489 1.00 28.73 ? 363 THR A C 1 ATOM 2553 O O . THR A 1 336 ? -7.240 -22.278 14.549 1.00 28.18 ? 363 THR A O 1 ATOM 2554 C CB . THR A 1 336 ? -7.424 -22.897 11.110 1.00 26.51 ? 363 THR A CB 1 ATOM 2555 O OG1 . THR A 1 336 ? -8.796 -22.837 10.702 1.00 26.02 ? 363 THR A OG1 1 ATOM 2556 C CG2 . THR A 1 336 ? -7.143 -24.309 11.645 1.00 27.53 ? 363 THR A CG2 1 ATOM 2557 N N . HIS A 1 337 ? -9.201 -22.194 13.444 1.00 27.62 ? 364 HIS A N 1 ATOM 2558 C CA . HIS A 1 337 ? -9.974 -22.326 14.668 1.00 27.47 ? 364 HIS A CA 1 ATOM 2559 C C . HIS A 1 337 ? -11.033 -23.376 14.487 1.00 29.21 ? 364 HIS A C 1 ATOM 2560 O O . HIS A 1 337 ? -11.312 -23.794 13.358 1.00 29.63 ? 364 HIS A O 1 ATOM 2561 C CB . HIS A 1 337 ? -10.649 -20.988 15.026 1.00 26.89 ? 364 HIS A CB 1 ATOM 2562 C CG . HIS A 1 337 ? -9.689 -19.915 15.423 1.00 26.00 ? 364 HIS A CG 1 ATOM 2563 N ND1 . HIS A 1 337 ? -9.155 -19.828 16.687 1.00 28.66 ? 364 HIS A ND1 1 ATOM 2564 C CD2 . HIS A 1 337 ? -9.137 -18.905 14.713 1.00 26.36 ? 364 HIS A CD2 1 ATOM 2565 C CE1 . HIS A 1 337 ? -8.323 -18.801 16.749 1.00 28.27 ? 364 HIS A CE1 1 ATOM 2566 N NE2 . HIS A 1 337 ? -8.293 -18.225 15.561 1.00 27.37 ? 364 HIS A NE2 1 ATOM 2567 N N . PRO A 1 338 ? -11.668 -23.773 15.591 1.00 28.65 ? 365 PRO A N 1 ATOM 2568 C CA . PRO A 1 338 ? -12.810 -24.671 15.494 1.00 28.72 ? 365 PRO A CA 1 ATOM 2569 C C . PRO A 1 338 ? -14.067 -24.032 14.853 1.00 27.65 ? 365 PRO A C 1 ATOM 2570 O O . PRO A 1 338 ? -14.220 -22.798 14.793 1.00 26.56 ? 365 PRO A O 1 ATOM 2571 C CB . PRO A 1 338 ? -13.099 -25.036 16.954 1.00 30.08 ? 365 PRO A CB 1 ATOM 2572 C CG . PRO A 1 338 ? -11.905 -24.559 17.742 1.00 31.70 ? 365 PRO A CG 1 ATOM 2573 C CD . PRO A 1 338 ? -11.375 -23.394 16.984 1.00 30.41 ? 365 PRO A CD 1 ATOM 2574 N N . ILE A 1 339 ? -14.979 -24.881 14.416 1.00 25.74 ? 366 ILE A N 1 ATOM 2575 C CA . ILE A 1 339 ? -16.165 -24.435 13.703 1.00 27.18 ? 366 ILE A CA 1 ATOM 2576 C C . ILE A 1 339 ? -16.922 -23.313 14.406 1.00 27.12 ? 366 ILE A C 1 ATOM 2577 O O . ILE A 1 339 ? -17.289 -22.331 13.771 1.00 26.81 ? 366 ILE A O 1 ATOM 2578 C CB . ILE A 1 339 ? -17.103 -25.630 13.460 1.00 28.94 ? 366 ILE A CB 1 ATOM 2579 C CG1 . ILE A 1 339 ? -16.541 -26.510 12.355 1.00 30.97 ? 366 ILE A CG1 1 ATOM 2580 C CG2 . ILE A 1 339 ? -18.503 -25.190 13.088 1.00 29.56 ? 366 ILE A CG2 1 ATOM 2581 C CD1 . ILE A 1 339 ? -17.097 -27.924 12.430 1.00 34.57 ? 366 ILE A CD1 1 ATOM 2582 N N . SER A 1 340 ? -17.143 -23.452 15.705 1.00 26.88 ? 367 SER A N 1 ATOM 2583 C CA . SER A 1 340 ? -17.905 -22.461 16.491 1.00 26.07 ? 367 SER A CA 1 ATOM 2584 C C . SER A 1 340 ? -17.323 -21.063 16.444 1.00 25.08 ? 367 SER A C 1 ATOM 2585 O O . SER A 1 340 ? -18.020 -20.087 16.635 1.00 27.00 ? 367 SER A O 1 ATOM 2586 C CB . SER A 1 340 ? -17.987 -22.895 17.954 1.00 24.98 ? 367 SER A CB 1 ATOM 2587 O OG . SER A 1 340 ? -16.673 -22.923 18.547 1.00 29.04 ? 367 SER A OG 1 ATOM 2588 N N . TYR A 1 341 ? -16.034 -20.971 16.227 1.00 24.89 ? 368 TYR A N 1 ATOM 2589 C CA . TYR A 1 341 ? -15.359 -19.698 16.235 1.00 26.37 ? 368 TYR A CA 1 ATOM 2590 C C . TYR A 1 341 ? -15.929 -18.759 15.154 1.00 25.50 ? 368 TYR A C 1 ATOM 2591 O O . TYR A 1 341 ? -16.038 -17.552 15.350 1.00 25.22 ? 368 TYR A O 1 ATOM 2592 C CB . TYR A 1 341 ? -13.870 -19.952 16.020 1.00 25.67 ? 368 TYR A CB 1 ATOM 2593 C CG . TYR A 1 341 ? -13.032 -18.707 16.060 1.00 28.20 ? 368 TYR A CG 1 ATOM 2594 C CD1 . TYR A 1 341 ? -12.605 -18.150 17.274 1.00 27.63 ? 368 TYR A CD1 1 ATOM 2595 C CD2 . TYR A 1 341 ? -12.643 -18.091 14.887 1.00 27.16 ? 368 TYR A CD2 1 ATOM 2596 C CE1 . TYR A 1 341 ? -11.825 -17.001 17.298 1.00 27.01 ? 368 TYR A CE1 1 ATOM 2597 C CE2 . TYR A 1 341 ? -11.858 -16.964 14.898 1.00 26.83 ? 368 TYR A CE2 1 ATOM 2598 C CZ . TYR A 1 341 ? -11.444 -16.425 16.089 1.00 28.13 ? 368 TYR A CZ 1 ATOM 2599 O OH . TYR A 1 341 ? -10.663 -15.298 16.029 1.00 27.34 ? 368 TYR A OH 1 ATOM 2600 N N . TYR A 1 342 ? -16.347 -19.350 14.039 1.00 25.83 ? 369 TYR A N 1 ATOM 2601 C CA . TYR A 1 342 ? -16.816 -18.598 12.882 1.00 24.84 ? 369 TYR A CA 1 ATOM 2602 C C . TYR A 1 342 ? -18.307 -18.263 12.995 1.00 26.08 ? 369 TYR A C 1 ATOM 2603 O O . TYR A 1 342 ? -18.845 -17.579 12.145 1.00 24.11 ? 369 TYR A O 1 ATOM 2604 C CB . TYR A 1 342 ? -16.522 -19.401 11.620 1.00 24.08 ? 369 TYR A CB 1 ATOM 2605 C CG . TYR A 1 342 ? -15.063 -19.770 11.502 1.00 24.97 ? 369 TYR A CG 1 ATOM 2606 C CD1 . TYR A 1 342 ? -14.148 -18.908 10.906 1.00 24.69 ? 369 TYR A CD1 1 ATOM 2607 C CD2 . TYR A 1 342 ? -14.577 -20.968 12.037 1.00 24.82 ? 369 TYR A CD2 1 ATOM 2608 C CE1 . TYR A 1 342 ? -12.796 -19.234 10.832 1.00 24.82 ? 369 TYR A CE1 1 ATOM 2609 C CE2 . TYR A 1 342 ? -13.228 -21.304 11.952 1.00 24.64 ? 369 TYR A CE2 1 ATOM 2610 C CZ . TYR A 1 342 ? -12.341 -20.438 11.357 1.00 25.26 ? 369 TYR A CZ 1 ATOM 2611 O OH . TYR A 1 342 ? -11.010 -20.792 11.270 1.00 23.65 ? 369 TYR A OH 1 ATOM 2612 N N . LYS A 1 343 ? -18.972 -18.754 14.046 1.00 29.69 ? 370 LYS A N 1 ATOM 2613 C CA . LYS A 1 343 ? -20.403 -18.484 14.307 1.00 30.34 ? 370 LYS A CA 1 ATOM 2614 C C . LYS A 1 343 ? -21.293 -18.835 13.134 1.00 30.70 ? 370 LYS A C 1 ATOM 2615 O O . LYS A 1 343 ? -22.061 -18.029 12.675 1.00 31.80 ? 370 LYS A O 1 ATOM 2616 C CB . LYS A 1 343 ? -20.636 -17.037 14.713 1.00 31.64 ? 370 LYS A CB 1 ATOM 2617 C CG . LYS A 1 343 ? -20.039 -16.676 16.066 1.00 36.16 ? 370 LYS A CG 1 ATOM 2618 C CD . LYS A 1 343 ? -20.393 -15.247 16.463 1.00 39.25 ? 370 LYS A CD 1 ATOM 2619 C CE . LYS A 1 343 ? -19.925 -14.890 17.870 1.00 42.70 ? 370 LYS A CE 1 ATOM 2620 N NZ . LYS A 1 343 ? -18.444 -14.924 17.987 1.00 47.80 ? 370 LYS A NZ 1 ATOM 2621 N N . PRO A 1 344 ? -21.213 -20.071 12.665 1.00 33.10 ? 371 PRO A N 1 ATOM 2622 C CA . PRO A 1 344 ? -22.219 -20.491 11.699 1.00 34.00 ? 371 PRO A CA 1 ATOM 2623 C C . PRO A 1 344 ? -23.636 -20.373 12.289 1.00 37.86 ? 371 PRO A C 1 ATOM 2624 O O . PRO A 1 344 ? -23.842 -20.690 13.455 1.00 35.68 ? 371 PRO A O 1 ATOM 2625 C CB . PRO A 1 344 ? -21.861 -21.950 11.451 1.00 32.55 ? 371 PRO A CB 1 ATOM 2626 C CG . PRO A 1 344 ? -21.287 -22.384 12.762 1.00 32.91 ? 371 PRO A CG 1 ATOM 2627 C CD . PRO A 1 344 ? -20.491 -21.212 13.247 1.00 31.78 ? 371 PRO A CD 1 ATOM 2628 N N . GLU A 1 345 ? -24.583 -19.889 11.498 1.00 41.18 ? 372 GLU A N 1 ATOM 2629 C CA . GLU A 1 345 ? -25.958 -19.711 11.957 1.00 43.02 ? 372 GLU A CA 1 ATOM 2630 C C . GLU A 1 345 ? -26.956 -20.409 11.050 1.00 43.32 ? 372 GLU A C 1 ATOM 2631 O O . GLU A 1 345 ? -26.851 -20.329 9.820 1.00 41.47 ? 372 GLU A O 1 ATOM 2632 C CB . GLU A 1 345 ? -26.296 -18.235 11.986 1.00 46.05 ? 372 GLU A CB 1 ATOM 2633 C CG . GLU A 1 345 ? -25.820 -17.506 13.218 1.00 53.05 ? 372 GLU A CG 1 ATOM 2634 C CD . GLU A 1 345 ? -26.112 -16.030 13.114 1.00 59.14 ? 372 GLU A CD 1 ATOM 2635 O OE1 . GLU A 1 345 ? -27.119 -15.589 13.715 1.00 65.03 ? 372 GLU A OE1 1 ATOM 2636 O OE2 . GLU A 1 345 ? -25.357 -15.334 12.391 1.00 64.75 ? 372 GLU A OE2 1 ATOM 2637 N N . PHE A 1 346 ? -27.943 -21.048 11.674 1.00 48.17 ? 373 PHE A N 1 ATOM 2638 C CA . PHE A 1 346 ? -29.060 -21.721 10.991 1.00 48.66 ? 373 PHE A CA 1 ATOM 2639 C C . PHE A 1 346 ? -30.438 -21.020 11.176 1.00 56.60 ? 373 PHE A C 1 ATOM 2640 O O . PHE A 1 346 ? -31.442 -21.466 10.623 1.00 62.53 ? 373 PHE A O 1 ATOM 2641 C CB . PHE A 1 346 ? -29.080 -23.169 11.460 1.00 47.97 ? 373 PHE A CB 1 ATOM 2642 C CG . PHE A 1 346 ? -27.755 -23.853 11.278 1.00 43.88 ? 373 PHE A CG 1 ATOM 2643 C CD1 . PHE A 1 346 ? -26.741 -23.669 12.191 1.00 45.83 ? 373 PHE A CD1 1 ATOM 2644 C CD2 . PHE A 1 346 ? -27.511 -24.631 10.169 1.00 42.83 ? 373 PHE A CD2 1 ATOM 2645 C CE1 . PHE A 1 346 ? -25.501 -24.263 12.009 1.00 44.91 ? 373 PHE A CE1 1 ATOM 2646 C CE2 . PHE A 1 346 ? -26.278 -25.220 9.969 1.00 46.56 ? 373 PHE A CE2 1 ATOM 2647 C CZ . PHE A 1 346 ? -25.264 -25.036 10.896 1.00 45.57 ? 373 PHE A CZ 1 ATOM 2648 N N . TYR A 1 347 ? -30.465 -19.919 11.936 1.00 61.34 ? 374 TYR A N 1 ATOM 2649 C CA . TYR A 1 347 ? -31.664 -19.098 12.176 1.00 64.74 ? 374 TYR A CA 1 ATOM 2650 C C . TYR A 1 347 ? -31.237 -17.652 12.431 1.00 72.52 ? 374 TYR A C 1 ATOM 2651 O O . TYR A 1 347 ? -30.144 -17.409 12.952 1.00 71.59 ? 374 TYR A O 1 ATOM 2652 C CB . TYR A 1 347 ? -32.412 -19.574 13.415 1.00 63.64 ? 374 TYR A CB 1 ATOM 2653 C CG . TYR A 1 347 ? -33.039 -20.925 13.276 1.00 62.61 ? 374 TYR A CG 1 ATOM 2654 C CD1 . TYR A 1 347 ? -32.319 -22.069 13.571 1.00 60.29 ? 374 TYR A CD1 1 ATOM 2655 C CD2 . TYR A 1 347 ? -34.362 -21.060 12.861 1.00 61.58 ? 374 TYR A CD2 1 ATOM 2656 C CE1 . TYR A 1 347 ? -32.888 -23.323 13.445 1.00 63.31 ? 374 TYR A CE1 1 ATOM 2657 C CE2 . TYR A 1 347 ? -34.952 -22.308 12.736 1.00 60.05 ? 374 TYR A CE2 1 ATOM 2658 C CZ . TYR A 1 347 ? -34.212 -23.440 13.029 1.00 62.84 ? 374 TYR A CZ 1 ATOM 2659 O OH . TYR A 1 347 ? -34.770 -24.702 12.907 1.00 66.33 ? 374 TYR A OH 1 ATOM 2660 N N . THR A 1 348 ? -32.090 -16.688 12.099 1.00 78.74 ? 375 THR A N 1 ATOM 2661 C CA . THR A 1 348 ? -31.765 -15.280 12.361 1.00 88.33 ? 375 THR A CA 1 ATOM 2662 C C . THR A 1 348 ? -32.051 -14.909 13.822 1.00 88.39 ? 375 THR A C 1 ATOM 2663 O O . THR A 1 348 ? -31.252 -14.226 14.466 1.00 87.32 ? 375 THR A O 1 ATOM 2664 C CB . THR A 1 348 ? -32.533 -14.340 11.409 1.00 94.78 ? 375 THR A CB 1 ATOM 2665 O OG1 . THR A 1 348 ? -32.171 -14.636 10.049 1.00 92.01 ? 375 THR A OG1 1 ATOM 2666 C CG2 . THR A 1 348 ? -32.221 -12.862 11.720 1.00 95.49 ? 375 THR A CG2 1 ATOM 2667 N N . THR B 2 1 ? -22.719 -29.106 -13.808 1.00 27.27 ? 381 THR B N 1 ATOM 2668 C CA . THR B 2 1 ? -22.593 -27.644 -13.981 1.00 28.00 ? 381 THR B CA 1 ATOM 2669 C C . THR B 2 1 ? -21.587 -27.319 -15.105 1.00 25.27 ? 381 THR B C 1 ATOM 2670 O O . THR B 2 1 ? -20.637 -28.046 -15.291 1.00 24.62 ? 381 THR B O 1 ATOM 2671 C CB . THR B 2 1 ? -22.199 -26.984 -12.631 1.00 29.16 ? 381 THR B CB 1 ATOM 2672 O OG1 . THR B 2 1 ? -23.192 -27.323 -11.658 1.00 32.39 ? 381 THR B OG1 1 ATOM 2673 C CG2 . THR B 2 1 ? -22.156 -25.495 -12.761 1.00 29.14 ? 381 THR B CG2 1 ATOM 2674 N N . ALA B 2 2 ? -21.843 -26.272 -15.886 1.00 23.16 ? 382 ALA B N 1 ATOM 2675 C CA . ALA B 2 2 ? -20.870 -25.759 -16.865 1.00 21.89 ? 382 ALA B CA 1 ATOM 2676 C C . ALA B 2 2 ? -20.875 -24.235 -16.842 1.00 21.42 ? 382 ALA B C 1 ATOM 2677 O O . ALA B 2 2 ? -21.927 -23.599 -16.694 1.00 22.27 ? 382 ALA B O 1 ATOM 2678 C CB . ALA B 2 2 ? -21.169 -26.241 -18.254 1.00 22.19 ? 382 ALA B CB 1 ATOM 2679 N N . HIS B 2 3 ? -19.694 -23.658 -16.939 1.00 21.18 ? 383 HIS B N 1 ATOM 2680 C CA . HIS B 2 3 ? -19.559 -22.229 -17.017 1.00 22.20 ? 383 HIS B CA 1 ATOM 2681 C C . HIS B 2 3 ? -19.039 -21.806 -18.351 1.00 24.07 ? 383 HIS B C 1 ATOM 2682 O O . HIS B 2 3 ? -18.133 -22.409 -18.908 1.00 23.20 ? 383 HIS B O 1 ATOM 2683 C CB . HIS B 2 3 ? -18.634 -21.625 -15.977 1.00 22.40 ? 383 HIS B CB 1 ATOM 2684 C CG . HIS B 2 3 ? -18.656 -20.137 -16.052 1.00 23.34 ? 383 HIS B CG 1 ATOM 2685 N ND1 . HIS B 2 3 ? -19.733 -19.401 -15.617 1.00 22.82 ? 383 HIS B ND1 1 ATOM 2686 C CD2 . HIS B 2 3 ? -17.839 -19.271 -16.684 1.00 23.27 ? 383 HIS B CD2 1 ATOM 2687 C CE1 . HIS B 2 3 ? -19.549 -18.133 -15.924 1.00 24.15 ? 383 HIS B CE1 1 ATOM 2688 N NE2 . HIS B 2 3 ? -18.410 -18.029 -16.582 1.00 23.15 ? 383 HIS B NE2 1 ATOM 2689 N N . LEU B 2 4 ? -19.561 -20.684 -18.808 1.00 26.48 ? 384 LEU B N 1 ATOM 2690 C CA . LEU B 2 4 ? -19.167 -20.133 -20.079 1.00 29.13 ? 384 LEU B CA 1 ATOM 2691 C C . LEU B 2 4 ? -19.027 -18.612 -19.994 1.00 26.70 ? 384 LEU B C 1 ATOM 2692 O O . LEU B 2 4 ? -19.877 -17.947 -19.373 1.00 26.01 ? 384 LEU B O 1 ATOM 2693 C CB . LEU B 2 4 ? -20.291 -20.517 -21.003 1.00 33.64 ? 384 LEU B CB 1 ATOM 2694 C CG . LEU B 2 4 ? -20.257 -20.276 -22.471 1.00 38.01 ? 384 LEU B CG 1 ATOM 2695 C CD1 . LEU B 2 4 ? -20.632 -21.592 -23.144 1.00 40.86 ? 384 LEU B CD1 1 ATOM 2696 C CD2 . LEU B 2 4 ? -21.269 -19.196 -22.773 1.00 37.57 ? 384 LEU B CD2 1 ATOM 2697 N N . SER B 2 5 ? -17.985 -18.061 -20.622 1.00 25.41 ? 385 SER B N 1 ATOM 2698 C CA . SER B 2 5 ? -17.782 -16.602 -20.654 1.00 25.80 ? 385 SER B CA 1 ATOM 2699 C C . SER B 2 5 ? -17.685 -16.057 -22.078 1.00 26.56 ? 385 SER B C 1 ATOM 2700 O O . SER B 2 5 ? -17.009 -16.627 -22.946 1.00 29.05 ? 385 SER B O 1 ATOM 2701 C CB . SER B 2 5 ? -16.533 -16.225 -19.860 1.00 24.93 ? 385 SER B CB 1 ATOM 2702 O OG . SER B 2 5 ? -16.655 -16.604 -18.481 1.00 23.64 ? 385 SER B OG 1 ATOM 2703 N N . VAL B 2 6 ? -18.352 -14.940 -22.318 1.00 27.96 ? 386 VAL B N 1 ATOM 2704 C CA . VAL B 2 6 ? -18.371 -14.313 -23.636 1.00 28.73 ? 386 VAL B CA 1 ATOM 2705 C C . VAL B 2 6 ? -18.142 -12.804 -23.597 1.00 28.88 ? 386 VAL B C 1 ATOM 2706 O O . VAL B 2 6 ? -18.734 -12.102 -22.775 1.00 25.69 ? 386 VAL B O 1 ATOM 2707 C CB . VAL B 2 6 ? -19.697 -14.583 -24.353 1.00 28.05 ? 386 VAL B CB 1 ATOM 2708 C CG1 . VAL B 2 6 ? -19.656 -14.047 -25.772 1.00 30.17 ? 386 VAL B CG1 1 ATOM 2709 C CG2 . VAL B 2 6 ? -19.982 -16.070 -24.390 1.00 27.93 ? 386 VAL B CG2 1 ATOM 2710 N N . VAL B 2 7 ? -17.272 -12.314 -24.489 1.00 27.75 ? 387 VAL B N 1 ATOM 2711 C CA . VAL B 2 7 ? -17.184 -10.876 -24.763 1.00 29.36 ? 387 VAL B CA 1 ATOM 2712 C C . VAL B 2 7 ? -17.353 -10.616 -26.260 1.00 29.19 ? 387 VAL B C 1 ATOM 2713 O O . VAL B 2 7 ? -16.622 -11.151 -27.077 1.00 29.83 ? 387 VAL B O 1 ATOM 2714 C CB . VAL B 2 7 ? -15.830 -10.280 -24.329 1.00 30.69 ? 387 VAL B CB 1 ATOM 2715 C CG1 . VAL B 2 7 ? -15.799 -8.774 -24.615 1.00 30.12 ? 387 VAL B CG1 1 ATOM 2716 C CG2 . VAL B 2 7 ? -15.548 -10.586 -22.862 1.00 29.93 ? 387 VAL B CG2 1 ATOM 2717 N N . ALA B 2 8 ? -18.301 -9.775 -26.616 1.00 30.01 ? 388 ALA B N 1 ATOM 2718 C CA . ALA B 2 8 ? -18.495 -9.392 -28.017 1.00 31.13 ? 388 ALA B CA 1 ATOM 2719 C C . ALA B 2 8 ? -17.689 -8.150 -28.418 1.00 33.16 ? 388 ALA B C 1 ATOM 2720 O O . ALA B 2 8 ? -17.149 -7.416 -27.581 1.00 33.82 ? 388 ALA B O 1 ATOM 2721 C CB . ALA B 2 8 ? -19.967 -9.159 -28.292 1.00 30.26 ? 388 ALA B CB 1 ATOM 2722 N N . GLU B 2 9 ? -17.659 -7.913 -29.720 1.00 35.97 ? 389 GLU B N 1 ATOM 2723 C CA . GLU B 2 9 ? -16.877 -6.834 -30.330 1.00 38.55 ? 389 GLU B CA 1 ATOM 2724 C C . GLU B 2 9 ? -17.255 -5.470 -29.796 1.00 34.83 ? 389 GLU B C 1 ATOM 2725 O O . GLU B 2 9 ? -16.396 -4.683 -29.547 1.00 34.72 ? 389 GLU B O 1 ATOM 2726 C CB . GLU B 2 9 ? -17.050 -6.867 -31.848 1.00 43.17 ? 389 GLU B CB 1 ATOM 2727 C CG . GLU B 2 9 ? -16.061 -6.000 -32.592 1.00 50.52 ? 389 GLU B CG 1 ATOM 2728 C CD . GLU B 2 9 ? -15.920 -6.400 -34.048 1.00 52.80 ? 389 GLU B CD 1 ATOM 2729 O OE1 . GLU B 2 9 ? -16.787 -7.148 -34.568 1.00 53.35 ? 389 GLU B OE1 1 ATOM 2730 O OE2 . GLU B 2 9 ? -14.920 -5.965 -34.653 1.00 58.29 ? 389 GLU B OE2 1 ATOM 2731 N N . ASP B 2 10 ? -18.538 -5.228 -29.561 1.00 35.90 ? 390 ASP B N 1 ATOM 2732 C CA . ASP B 2 10 ? -18.998 -3.973 -28.973 1.00 36.42 ? 390 ASP B CA 1 ATOM 2733 C C . ASP B 2 10 ? -18.645 -3.804 -27.488 1.00 36.05 ? 390 ASP B C 1 ATOM 2734 O O . ASP B 2 10 ? -19.016 -2.801 -26.880 1.00 37.37 ? 390 ASP B O 1 ATOM 2735 C CB . ASP B 2 10 ? -20.528 -3.785 -29.193 1.00 38.28 ? 390 ASP B CB 1 ATOM 2736 C CG . ASP B 2 10 ? -21.395 -4.670 -28.267 1.00 44.27 ? 390 ASP B CG 1 ATOM 2737 O OD1 . ASP B 2 10 ? -20.855 -5.607 -27.659 1.00 42.89 ? 390 ASP B OD1 1 ATOM 2738 O OD2 . ASP B 2 10 ? -22.623 -4.429 -28.140 1.00 50.36 ? 390 ASP B OD2 1 ATOM 2739 N N . GLY B 2 11 ? -17.963 -4.780 -26.891 1.00 35.17 ? 391 GLY B N 1 ATOM 2740 C CA . GLY B 2 11 ? -17.574 -4.685 -25.488 1.00 35.28 ? 391 GLY B CA 1 ATOM 2741 C C . GLY B 2 11 ? -18.626 -5.220 -24.512 1.00 33.25 ? 391 GLY B C 1 ATOM 2742 O O . GLY B 2 11 ? -18.411 -5.235 -23.296 1.00 31.90 ? 391 GLY B O 1 ATOM 2743 N N . SER B 2 12 ? -19.767 -5.660 -25.023 1.00 30.86 ? 392 SER B N 1 ATOM 2744 C CA . SER B 2 12 ? -20.761 -6.334 -24.181 1.00 30.36 ? 392 SER B CA 1 ATOM 2745 C C . SER B 2 12 ? -20.315 -7.745 -23.771 1.00 28.42 ? 392 SER B C 1 ATOM 2746 O O . SER B 2 12 ? -19.465 -8.343 -24.409 1.00 29.06 ? 392 SER B O 1 ATOM 2747 C CB . SER B 2 12 ? -22.087 -6.395 -24.903 1.00 32.46 ? 392 SER B CB 1 ATOM 2748 O OG . SER B 2 12 ? -22.622 -5.092 -24.956 1.00 36.18 ? 392 SER B OG 1 ATOM 2749 N N . ALA B 2 13 ? -20.874 -8.266 -22.687 1.00 26.21 ? 393 ALA B N 1 ATOM 2750 C CA . ALA B 2 13 ? -20.394 -9.523 -22.159 1.00 25.18 ? 393 ALA B CA 1 ATOM 2751 C C . ALA B 2 13 ? -21.487 -10.346 -21.493 1.00 23.87 ? 393 ALA B C 1 ATOM 2752 O O . ALA B 2 13 ? -22.474 -9.807 -20.981 1.00 24.11 ? 393 ALA B O 1 ATOM 2753 C CB . ALA B 2 13 ? -19.241 -9.270 -21.186 1.00 25.20 ? 393 ALA B CB 1 ATOM 2754 N N . VAL B 2 14 ? -21.287 -11.655 -21.503 1.00 23.23 ? 394 VAL B N 1 ATOM 2755 C CA . VAL B 2 14 ? -22.135 -12.610 -20.810 1.00 24.18 ? 394 VAL B CA 1 ATOM 2756 C C . VAL B 2 14 ? -21.294 -13.597 -19.998 1.00 23.97 ? 394 VAL B C 1 ATOM 2757 O O . VAL B 2 14 ? -20.288 -14.128 -20.485 1.00 23.93 ? 394 VAL B O 1 ATOM 2758 C CB . VAL B 2 14 ? -23.010 -13.399 -21.794 1.00 25.66 ? 394 VAL B CB 1 ATOM 2759 C CG1 . VAL B 2 14 ? -23.891 -14.403 -21.052 1.00 26.55 ? 394 VAL B CG1 1 ATOM 2760 C CG2 . VAL B 2 14 ? -23.876 -12.440 -22.598 1.00 25.55 ? 394 VAL B CG2 1 ATOM 2761 N N . SER B 2 15 ? -21.706 -13.799 -18.750 1.00 21.89 ? 395 SER B N 1 ATOM 2762 C CA . SER B 2 15 ? -21.192 -14.844 -17.878 1.00 21.71 ? 395 SER B CA 1 ATOM 2763 C C . SER B 2 15 ? -22.387 -15.755 -17.561 1.00 21.41 ? 395 SER B C 1 ATOM 2764 O O . SER B 2 15 ? -23.356 -15.317 -16.953 1.00 22.13 ? 395 SER B O 1 ATOM 2765 C CB . SER B 2 15 ? -20.606 -14.224 -16.602 1.00 21.97 ? 395 SER B CB 1 ATOM 2766 O OG . SER B 2 15 ? -19.623 -15.052 -15.992 1.00 22.53 ? 395 SER B OG 1 ATOM 2767 N N . ALA B 2 16 ? -22.326 -17.008 -17.992 1.00 22.77 ? 396 ALA B N 1 ATOM 2768 C CA . ALA B 2 16 ? -23.463 -17.926 -17.890 1.00 22.86 ? 396 ALA B CA 1 ATOM 2769 C C . ALA B 2 16 ? -23.024 -19.193 -17.214 1.00 22.55 ? 396 ALA B C 1 ATOM 2770 O O . ALA B 2 16 ? -22.087 -19.835 -17.673 1.00 24.38 ? 396 ALA B O 1 ATOM 2771 C CB . ALA B 2 16 ? -23.998 -18.247 -19.273 1.00 24.39 ? 396 ALA B CB 1 ATOM 2772 N N . THR B 2 17 ? -23.694 -19.555 -16.119 1.00 21.89 ? 397 THR B N 1 ATOM 2773 C CA . THR B 2 17 ? -23.480 -20.846 -15.490 1.00 22.25 ? 397 THR B CA 1 ATOM 2774 C C . THR B 2 17 ? -24.794 -21.619 -15.521 1.00 21.94 ? 397 THR B C 1 ATOM 2775 O O . THR B 2 17 ? -25.825 -21.112 -15.069 1.00 22.79 ? 397 THR B O 1 ATOM 2776 C CB . THR B 2 17 ? -22.976 -20.706 -14.037 1.00 23.15 ? 397 THR B CB 1 ATOM 2777 O OG1 . THR B 2 17 ? -21.917 -19.745 -13.960 1.00 22.00 ? 397 THR B OG1 1 ATOM 2778 C CG2 . THR B 2 17 ? -22.415 -22.016 -13.529 1.00 24.31 ? 397 THR B CG2 1 ATOM 2779 N N . SER B 2 18 ? -24.737 -22.850 -16.032 1.00 21.69 ? 398 SER B N 1 ATOM 2780 C CA . SER B 2 18 ? -25.897 -23.715 -16.230 1.00 22.01 ? 398 SER B CA 1 ATOM 2781 C C . SER B 2 18 ? -25.629 -25.081 -15.622 1.00 23.39 ? 398 SER B C 1 ATOM 2782 O O . SER B 2 18 ? -24.477 -25.515 -15.602 1.00 25.65 ? 398 SER B O 1 ATOM 2783 C CB . SER B 2 18 ? -26.126 -23.915 -17.727 1.00 23.99 ? 398 SER B CB 1 ATOM 2784 O OG . SER B 2 18 ? -27.214 -24.766 -17.962 1.00 23.72 ? 398 SER B OG 1 ATOM 2785 N N . THR B 2 19 ? -26.675 -25.770 -15.160 1.00 22.15 ? 399 THR B N 1 ATOM 2786 C CA . THR B 2 19 ? -26.513 -27.070 -14.513 1.00 22.49 ? 399 THR B CA 1 ATOM 2787 C C . THR B 2 19 ? -27.753 -27.973 -14.492 1.00 22.30 ? 399 THR B C 1 ATOM 2788 O O . THR B 2 19 ? -28.885 -27.485 -14.405 1.00 22.20 ? 399 THR B O 1 ATOM 2789 C CB . THR B 2 19 ? -26.086 -26.892 -13.050 1.00 23.09 ? 399 THR B CB 1 ATOM 2790 O OG1 . THR B 2 19 ? -25.701 -28.149 -12.479 1.00 23.06 ? 399 THR B OG1 1 ATOM 2791 C CG2 . THR B 2 19 ? -27.227 -26.300 -12.240 1.00 23.55 ? 399 THR B CG2 1 ATOM 2792 N N . ILE B 2 20 ? -27.514 -29.290 -14.553 1.00 22.17 ? 400 ILE B N 1 ATOM 2793 C CA . ILE B 2 20 ? -28.535 -30.308 -14.184 1.00 22.23 ? 400 ILE B CA 1 ATOM 2794 C C . ILE B 2 20 ? -28.261 -30.965 -12.834 1.00 23.45 ? 400 ILE B C 1 ATOM 2795 O O . ILE B 2 20 ? -28.890 -31.965 -12.445 1.00 22.29 ? 400 ILE B O 1 ATOM 2796 C CB . ILE B 2 20 ? -28.721 -31.377 -15.283 1.00 23.50 ? 400 ILE B CB 1 ATOM 2797 C CG1 . ILE B 2 20 ? -27.423 -32.067 -15.674 1.00 24.29 ? 400 ILE B CG1 1 ATOM 2798 C CG2 . ILE B 2 20 ? -29.355 -30.760 -16.522 1.00 23.81 ? 400 ILE B CG2 1 ATOM 2799 C CD1 . ILE B 2 20 ? -27.649 -33.320 -16.508 1.00 23.28 ? 400 ILE B CD1 1 ATOM 2800 N N . ASN B 2 21 ? -27.336 -30.336 -12.103 1.00 23.14 ? 401 ASN B N 1 ATOM 2801 C CA . ASN B 2 21 ? -26.892 -30.738 -10.808 1.00 23.73 ? 401 ASN B CA 1 ATOM 2802 C C . ASN B 2 21 ? -25.851 -31.850 -10.831 1.00 23.54 ? 401 ASN B C 1 ATOM 2803 O O . ASN B 2 21 ? -24.737 -31.587 -11.238 1.00 23.52 ? 401 ASN B O 1 ATOM 2804 C CB . ASN B 2 21 ? -28.027 -30.982 -9.830 1.00 24.56 ? 401 ASN B CB 1 ATOM 2805 C CG . ASN B 2 21 ? -27.514 -31.143 -8.404 1.00 26.25 ? 401 ASN B CG 1 ATOM 2806 O OD1 . ASN B 2 21 ? -26.412 -30.702 -8.074 1.00 25.52 ? 401 ASN B OD1 1 ATOM 2807 N ND2 . ASN B 2 21 ? -28.293 -31.772 -7.568 1.00 27.86 ? 401 ASN B ND2 1 ATOM 2808 N N . LEU B 2 22 ? -26.161 -33.069 -10.410 1.00 24.14 ? 402 LEU B N 1 ATOM 2809 C CA . LEU B 2 22 ? -25.112 -34.082 -10.353 1.00 26.16 ? 402 LEU B CA 1 ATOM 2810 C C . LEU B 2 22 ? -24.849 -34.536 -11.769 1.00 28.06 ? 402 LEU B C 1 ATOM 2811 O O . LEU B 2 22 ? -25.558 -34.126 -12.680 1.00 26.56 ? 402 LEU B O 1 ATOM 2812 C CB . LEU B 2 22 ? -25.492 -35.269 -9.458 1.00 26.82 ? 402 LEU B CB 1 ATOM 2813 C CG . LEU B 2 22 ? -25.868 -34.913 -8.019 1.00 29.72 ? 402 LEU B CG 1 ATOM 2814 C CD1 . LEU B 2 22 ? -26.052 -36.187 -7.205 1.00 31.17 ? 402 LEU B CD1 1 ATOM 2815 C CD2 . LEU B 2 22 ? -24.795 -34.020 -7.367 1.00 31.32 ? 402 LEU B CD2 1 ATOM 2816 N N . TYR B 2 23 ? -23.835 -35.376 -11.956 1.00 29.06 ? 403 TYR B N 1 ATOM 2817 C CA . TYR B 2 23 ? -23.534 -35.930 -13.285 1.00 30.46 ? 403 TYR B CA 1 ATOM 2818 C C . TYR B 2 23 ? -24.741 -36.656 -13.836 1.00 27.67 ? 403 TYR B C 1 ATOM 2819 O O . TYR B 2 23 ? -25.263 -37.556 -13.193 1.00 30.43 ? 403 TYR B O 1 ATOM 2820 C CB . TYR B 2 23 ? -22.369 -36.917 -13.226 1.00 32.34 ? 403 TYR B CB 1 ATOM 2821 C CG . TYR B 2 23 ? -20.986 -36.339 -12.985 1.00 34.59 ? 403 TYR B CG 1 ATOM 2822 C CD1 . TYR B 2 23 ? -20.735 -34.979 -13.085 1.00 36.37 ? 403 TYR B CD1 1 ATOM 2823 C CD2 . TYR B 2 23 ? -19.905 -37.188 -12.723 1.00 37.06 ? 403 TYR B CD2 1 ATOM 2824 C CE1 . TYR B 2 23 ? -19.464 -34.472 -12.883 1.00 40.04 ? 403 TYR B CE1 1 ATOM 2825 C CE2 . TYR B 2 23 ? -18.621 -36.689 -12.547 1.00 38.49 ? 403 TYR B CE2 1 ATOM 2826 C CZ . TYR B 2 23 ? -18.402 -35.336 -12.624 1.00 40.87 ? 403 TYR B CZ 1 ATOM 2827 O OH . TYR B 2 23 ? -17.126 -34.815 -12.433 1.00 43.33 ? 403 TYR B OH 1 ATOM 2828 N N . PHE B 2 24 ? -25.177 -36.272 -15.027 1.00 26.82 ? 404 PHE B N 1 ATOM 2829 C CA . PHE B 2 24 ? -26.389 -36.840 -15.665 1.00 27.52 ? 404 PHE B CA 1 ATOM 2830 C C . PHE B 2 24 ? -27.682 -36.619 -14.866 1.00 26.21 ? 404 PHE B C 1 ATOM 2831 O O . PHE B 2 24 ? -28.669 -37.318 -15.066 1.00 25.60 ? 404 PHE B O 1 ATOM 2832 C CB . PHE B 2 24 ? -26.225 -38.317 -15.977 1.00 28.39 ? 404 PHE B CB 1 ATOM 2833 C CG . PHE B 2 24 ? -24.959 -38.637 -16.698 1.00 28.06 ? 404 PHE B CG 1 ATOM 2834 C CD1 . PHE B 2 24 ? -24.875 -38.473 -18.065 1.00 29.41 ? 404 PHE B CD1 1 ATOM 2835 C CD2 . PHE B 2 24 ? -23.857 -39.117 -16.008 1.00 28.55 ? 404 PHE B CD2 1 ATOM 2836 C CE1 . PHE B 2 24 ? -23.698 -38.766 -18.743 1.00 29.77 ? 404 PHE B CE1 1 ATOM 2837 C CE2 . PHE B 2 24 ? -22.681 -39.415 -16.669 1.00 29.62 ? 404 PHE B CE2 1 ATOM 2838 C CZ . PHE B 2 24 ? -22.601 -39.237 -18.044 1.00 29.08 ? 404 PHE B CZ 1 ATOM 2839 N N . GLY B 2 25 ? -27.670 -35.622 -13.984 1.00 25.00 ? 405 GLY B N 1 ATOM 2840 C CA . GLY B 2 25 ? -28.850 -35.216 -13.247 1.00 24.15 ? 405 GLY B CA 1 ATOM 2841 C C . GLY B 2 25 ? -29.541 -36.341 -12.507 1.00 24.99 ? 405 GLY B C 1 ATOM 2842 O O . GLY B 2 25 ? -28.914 -37.097 -11.739 1.00 25.04 ? 405 GLY B O 1 ATOM 2843 N N . SER B 2 26 ? -30.843 -36.444 -12.740 1.00 23.28 ? 406 SER B N 1 ATOM 2844 C CA . SER B 2 26 ? -31.666 -37.445 -12.099 1.00 25.15 ? 406 SER B CA 1 ATOM 2845 C C . SER B 2 26 ? -31.420 -38.865 -12.632 1.00 26.01 ? 406 SER B C 1 ATOM 2846 O O . SER B 2 26 ? -31.934 -39.818 -12.070 1.00 25.47 ? 406 SER B O 1 ATOM 2847 C CB . SER B 2 26 ? -33.128 -37.096 -12.346 1.00 24.19 ? 406 SER B CB 1 ATOM 2848 O OG . SER B 2 26 ? -33.381 -37.112 -13.743 1.00 21.76 ? 406 SER B OG 1 ATOM 2849 N N . LYS B 2 27 ? -30.655 -38.987 -13.715 1.00 25.94 ? 407 LYS B N 1 ATOM 2850 C CA . LYS B 2 27 ? -30.486 -40.234 -14.441 1.00 28.59 ? 407 LYS B CA 1 ATOM 2851 C C . LYS B 2 27 ? -31.737 -40.610 -15.217 1.00 28.51 ? 407 LYS B C 1 ATOM 2852 O O . LYS B 2 27 ? -31.797 -41.699 -15.779 1.00 30.53 ? 407 LYS B O 1 ATOM 2853 C CB . LYS B 2 27 ? -30.038 -41.401 -13.547 1.00 30.94 ? 407 LYS B CB 1 ATOM 2854 C CG . LYS B 2 27 ? -28.969 -41.050 -12.526 1.00 34.61 ? 407 LYS B CG 1 ATOM 2855 C CD . LYS B 2 27 ? -27.724 -40.494 -13.172 1.00 35.48 ? 407 LYS B CD 1 ATOM 2856 C CE . LYS B 2 27 ? -26.650 -40.216 -12.132 1.00 39.53 ? 407 LYS B CE 1 ATOM 2857 N NZ . LYS B 2 27 ? -26.984 -39.126 -11.157 1.00 39.22 ? 407 LYS B NZ 1 ATOM 2858 N N . VAL B 2 28 ? -32.713 -39.703 -15.283 1.00 28.92 ? 408 VAL B N 1 ATOM 2859 C CA . VAL B 2 28 ? -33.893 -39.910 -16.109 1.00 27.40 ? 408 VAL B CA 1 ATOM 2860 C C . VAL B 2 28 ? -33.719 -39.225 -17.457 1.00 28.78 ? 408 VAL B C 1 ATOM 2861 O O . VAL B 2 28 ? -33.740 -37.977 -17.536 1.00 25.89 ? 408 VAL B O 1 ATOM 2862 C CB . VAL B 2 28 ? -35.145 -39.356 -15.435 1.00 27.95 ? 408 VAL B CB 1 ATOM 2863 C CG1 . VAL B 2 28 ? -36.362 -39.559 -16.329 1.00 28.18 ? 408 VAL B CG1 1 ATOM 2864 C CG2 . VAL B 2 28 ? -35.319 -40.039 -14.072 1.00 26.64 ? 408 VAL B CG2 1 ATOM 2865 N N . ARG B 2 29 ? -33.524 -40.052 -18.502 1.00 29.04 ? 409 ARG B N 1 ATOM 2866 C CA . ARG B 2 29 ? -33.546 -39.617 -19.905 1.00 27.75 ? 409 ARG B CA 1 ATOM 2867 C C . ARG B 2 29 ? -34.858 -39.979 -20.574 1.00 26.62 ? 409 ARG B C 1 ATOM 2868 O O . ARG B 2 29 ? -35.371 -41.077 -20.401 1.00 27.04 ? 409 ARG B O 1 ATOM 2869 C CB . ARG B 2 29 ? -32.380 -40.230 -20.680 1.00 27.51 ? 409 ARG B CB 1 ATOM 2870 C CG . ARG B 2 29 ? -32.373 -39.884 -22.169 1.00 27.36 ? 409 ARG B CG 1 ATOM 2871 C CD . ARG B 2 29 ? -31.210 -40.538 -22.913 1.00 27.50 ? 409 ARG B CD 1 ATOM 2872 N NE . ARG B 2 29 ? -31.289 -40.278 -24.347 1.00 28.08 ? 409 ARG B NE 1 ATOM 2873 C CZ . ARG B 2 29 ? -31.875 -41.079 -25.237 1.00 30.04 ? 409 ARG B CZ 1 ATOM 2874 N NH1 . ARG B 2 29 ? -32.445 -42.227 -24.874 1.00 32.14 ? 409 ARG B NH1 1 ATOM 2875 N NH2 . ARG B 2 29 ? -31.916 -40.715 -26.497 1.00 30.42 ? 409 ARG B NH2 1 ATOM 2876 N N . SER B 2 30 ? -35.418 -39.058 -21.342 1.00 27.54 ? 410 SER B N 1 ATOM 2877 C CA . SER B 2 30 ? -36.598 -39.377 -22.123 1.00 28.74 ? 410 SER B CA 1 ATOM 2878 C C . SER B 2 30 ? -36.194 -40.221 -23.333 1.00 29.33 ? 410 SER B C 1 ATOM 2879 O O . SER B 2 30 ? -35.355 -39.787 -24.118 1.00 27.72 ? 410 SER B O 1 ATOM 2880 C CB . SER B 2 30 ? -37.280 -38.119 -22.635 1.00 30.23 ? 410 SER B CB 1 ATOM 2881 O OG . SER B 2 30 ? -38.371 -38.456 -23.506 1.00 28.69 ? 410 SER B OG 1 ATOM 2882 N N . PRO B 2 31 ? -36.821 -41.403 -23.510 1.00 30.79 ? 411 PRO B N 1 ATOM 2883 C CA . PRO B 2 31 ? -36.544 -42.183 -24.724 1.00 31.82 ? 411 PRO B CA 1 ATOM 2884 C C . PRO B 2 31 ? -37.091 -41.544 -25.995 1.00 30.37 ? 411 PRO B C 1 ATOM 2885 O O . PRO B 2 31 ? -36.630 -41.890 -27.072 1.00 32.29 ? 411 PRO B O 1 ATOM 2886 C CB . PRO B 2 31 ? -37.233 -43.537 -24.466 1.00 31.09 ? 411 PRO B CB 1 ATOM 2887 C CG . PRO B 2 31 ? -38.279 -43.246 -23.471 1.00 33.61 ? 411 PRO B CG 1 ATOM 2888 C CD . PRO B 2 31 ? -37.808 -42.066 -22.641 1.00 31.76 ? 411 PRO B CD 1 ATOM 2889 N N . VAL B 2 32 ? -38.056 -40.634 -25.867 1.00 29.53 ? 412 VAL B N 1 ATOM 2890 C CA . VAL B 2 32 ? -38.647 -39.966 -27.010 1.00 27.72 ? 412 VAL B CA 1 ATOM 2891 C C . VAL B 2 32 ? -37.952 -38.641 -27.342 1.00 27.62 ? 412 VAL B C 1 ATOM 2892 O O . VAL B 2 32 ? -37.609 -38.409 -28.485 1.00 26.41 ? 412 VAL B O 1 ATOM 2893 C CB . VAL B 2 32 ? -40.142 -39.716 -26.786 1.00 30.43 ? 412 VAL B CB 1 ATOM 2894 C CG1 . VAL B 2 32 ? -40.761 -38.949 -27.971 1.00 30.75 ? 412 VAL B CG1 1 ATOM 2895 C CG2 . VAL B 2 32 ? -40.888 -41.036 -26.538 1.00 31.31 ? 412 VAL B CG2 1 ATOM 2896 N N . SER B 2 33 ? -37.755 -37.761 -26.355 1.00 27.29 ? 413 SER B N 1 ATOM 2897 C CA . SER B 2 33 ? -37.213 -36.430 -26.621 1.00 25.73 ? 413 SER B CA 1 ATOM 2898 C C . SER B 2 33 ? -35.702 -36.382 -26.479 1.00 26.56 ? 413 SER B C 1 ATOM 2899 O O . SER B 2 33 ? -35.048 -35.511 -27.059 1.00 24.48 ? 413 SER B O 1 ATOM 2900 C CB . SER B 2 33 ? -37.828 -35.395 -25.666 1.00 26.97 ? 413 SER B CB 1 ATOM 2901 O OG . SER B 2 33 ? -37.307 -35.538 -24.362 1.00 25.51 ? 413 SER B OG 1 ATOM 2902 N N . GLY B 2 34 ? -35.144 -37.292 -25.679 1.00 26.69 ? 414 GLY B N 1 ATOM 2903 C CA . GLY B 2 34 ? -33.707 -37.293 -25.423 1.00 26.39 ? 414 GLY B CA 1 ATOM 2904 C C . GLY B 2 34 ? -33.300 -36.377 -24.261 1.00 26.65 ? 414 GLY B C 1 ATOM 2905 O O . GLY B 2 34 ? -32.119 -36.330 -23.898 1.00 26.16 ? 414 GLY B O 1 ATOM 2906 N N . ILE B 2 35 ? -34.259 -35.663 -23.674 1.00 25.41 ? 415 ILE B N 1 ATOM 2907 C CA . ILE B 2 35 ? -33.955 -34.700 -22.604 1.00 24.42 ? 415 ILE B CA 1 ATOM 2908 C C . ILE B 2 35 ? -33.481 -35.453 -21.354 1.00 25.33 ? 415 ILE B C 1 ATOM 2909 O O . ILE B 2 35 ? -34.078 -36.447 -20.932 1.00 26.39 ? 415 ILE B O 1 ATOM 2910 C CB . ILE B 2 35 ? -35.157 -33.837 -22.257 1.00 24.39 ? 415 ILE B CB 1 ATOM 2911 C CG1 . ILE B 2 35 ? -35.490 -32.913 -23.419 1.00 24.38 ? 415 ILE B CG1 1 ATOM 2912 C CG2 . ILE B 2 35 ? -34.877 -32.967 -21.021 1.00 24.94 ? 415 ILE B CG2 1 ATOM 2913 C CD1 . ILE B 2 35 ? -36.901 -32.369 -23.334 1.00 25.06 ? 415 ILE B CD1 1 ATOM 2914 N N . LEU B 2 36 ? -32.376 -35.002 -20.795 1.00 25.39 ? 416 LEU B N 1 ATOM 2915 C CA . LEU B 2 36 ? -31.855 -35.556 -19.560 1.00 25.85 ? 416 LEU B CA 1 ATOM 2916 C C . LEU B 2 36 ? -32.268 -34.594 -18.438 1.00 25.29 ? 416 LEU B C 1 ATOM 2917 O O . LEU B 2 36 ? -31.867 -33.417 -18.459 1.00 24.59 ? 416 LEU B O 1 ATOM 2918 C CB . LEU B 2 36 ? -30.353 -35.667 -19.689 1.00 27.85 ? 416 LEU B CB 1 ATOM 2919 C CG . LEU B 2 36 ? -29.582 -36.389 -18.596 1.00 33.36 ? 416 LEU B CG 1 ATOM 2920 C CD1 . LEU B 2 36 ? -30.117 -37.791 -18.300 1.00 34.75 ? 416 LEU B CD1 1 ATOM 2921 C CD2 . LEU B 2 36 ? -28.123 -36.467 -19.026 1.00 35.34 ? 416 LEU B CD2 1 ATOM 2922 N N . PHE B 2 37 ? -33.075 -35.087 -17.489 1.00 23.89 ? 417 PHE B N 1 ATOM 2923 C CA . PHE B 2 37 ? -33.666 -34.239 -16.457 1.00 24.19 ? 417 PHE B CA 1 ATOM 2924 C C . PHE B 2 37 ? -32.791 -34.032 -15.221 1.00 23.45 ? 417 PHE B C 1 ATOM 2925 O O . PHE B 2 37 ? -32.121 -34.933 -14.749 1.00 22.72 ? 417 PHE B O 1 ATOM 2926 C CB . PHE B 2 37 ? -35.043 -34.730 -16.048 1.00 24.90 ? 417 PHE B CB 1 ATOM 2927 C CG . PHE B 2 37 ? -36.037 -34.723 -17.185 1.00 25.17 ? 417 PHE B CG 1 ATOM 2928 C CD1 . PHE B 2 37 ? -36.673 -33.576 -17.545 1.00 24.18 ? 417 PHE B CD1 1 ATOM 2929 C CD2 . PHE B 2 37 ? -36.293 -35.881 -17.903 1.00 25.98 ? 417 PHE B CD2 1 ATOM 2930 C CE1 . PHE B 2 37 ? -37.564 -33.573 -18.593 1.00 26.29 ? 417 PHE B CE1 1 ATOM 2931 C CE2 . PHE B 2 37 ? -37.190 -35.888 -18.956 1.00 25.33 ? 417 PHE B CE2 1 ATOM 2932 C CZ . PHE B 2 37 ? -37.828 -34.732 -19.299 1.00 25.29 ? 417 PHE B CZ 1 ATOM 2933 N N . ASN B 2 38 ? -32.816 -32.801 -14.731 1.00 22.58 ? 418 ASN B N 1 ATOM 2934 C CA . ASN B 2 38 ? -32.034 -32.381 -13.584 1.00 21.71 ? 418 ASN B CA 1 ATOM 2935 C C . ASN B 2 38 ? -32.459 -33.123 -12.346 1.00 21.90 ? 418 ASN B C 1 ATOM 2936 O O . ASN B 2 38 ? -33.549 -33.718 -12.328 1.00 23.24 ? 418 ASN B O 1 ATOM 2937 C CB . ASN B 2 38 ? -32.225 -30.904 -13.368 1.00 21.36 ? 418 ASN B CB 1 ATOM 2938 C CG . ASN B 2 38 ? -33.591 -30.580 -12.859 1.00 21.99 ? 418 ASN B CG 1 ATOM 2939 O OD1 . ASN B 2 38 ? -33.862 -30.719 -11.653 1.00 24.17 ? 418 ASN B OD1 1 ATOM 2940 N ND2 . ASN B 2 38 ? -34.474 -30.146 -13.757 1.00 22.49 ? 418 ASN B ND2 1 ATOM 2941 N N . ASN B 2 39 ? -31.565 -33.165 -11.364 1.00 21.59 ? 419 ASN B N 1 ATOM 2942 C CA . ASN B 2 39 ? -31.922 -33.513 -9.997 1.00 23.25 ? 419 ASN B CA 1 ATOM 2943 C C . ASN B 2 39 ? -31.660 -32.339 -9.057 1.00 23.60 ? 419 ASN B C 1 ATOM 2944 O O . ASN B 2 39 ? -31.093 -32.472 -7.995 1.00 21.54 ? 419 ASN B O 1 ATOM 2945 C CB . ASN B 2 39 ? -31.251 -34.805 -9.520 1.00 23.99 ? 419 ASN B CB 1 ATOM 2946 C CG . ASN B 2 39 ? -29.726 -34.765 -9.514 1.00 24.92 ? 419 ASN B CG 1 ATOM 2947 O OD1 . ASN B 2 39 ? -29.079 -33.936 -10.138 1.00 24.35 ? 419 ASN B OD1 1 ATOM 2948 N ND2 . ASN B 2 39 ? -29.145 -35.738 -8.828 1.00 26.36 ? 419 ASN B ND2 1 ATOM 2949 N N . GLU B 2 40 ? -32.162 -31.184 -9.450 1.00 24.14 ? 420 GLU B N 1 ATOM 2950 C CA . GLU B 2 40 ? -31.946 -29.977 -8.684 1.00 24.04 ? 420 GLU B CA 1 ATOM 2951 C C . GLU B 2 40 ? -32.691 -29.983 -7.356 1.00 23.90 ? 420 GLU B C 1 ATOM 2952 O O . GLU B 2 40 ? -32.331 -29.204 -6.458 1.00 23.00 ? 420 GLU B O 1 ATOM 2953 C CB . GLU B 2 40 ? -32.352 -28.763 -9.501 1.00 25.37 ? 420 GLU B CB 1 ATOM 2954 C CG . GLU B 2 40 ? -31.398 -27.599 -9.372 1.00 25.67 ? 420 GLU B CG 1 ATOM 2955 C CD . GLU B 2 40 ? -30.068 -27.837 -10.105 1.00 27.51 ? 420 GLU B CD 1 ATOM 2956 O OE1 . GLU B 2 40 ? -29.028 -27.680 -9.440 1.00 24.99 ? 420 GLU B OE1 1 ATOM 2957 O OE2 . GLU B 2 40 ? -30.068 -28.156 -11.329 1.00 25.05 ? 420 GLU B OE2 1 ATOM 2958 N N . MET B 2 41 ? -33.685 -30.865 -7.190 1.00 23.65 ? 421 MET B N 1 ATOM 2959 C CA . MET B 2 41 ? -34.354 -31.002 -5.868 1.00 23.97 ? 421 MET B CA 1 ATOM 2960 C C . MET B 2 41 ? -33.370 -31.397 -4.751 1.00 24.31 ? 421 MET B C 1 ATOM 2961 O O . MET B 2 41 ? -33.587 -31.066 -3.609 1.00 24.54 ? 421 MET B O 1 ATOM 2962 C CB . MET B 2 41 ? -35.542 -31.955 -5.916 1.00 23.75 ? 421 MET B CB 1 ATOM 2963 C CG . MET B 2 41 ? -36.608 -31.535 -6.925 1.00 24.87 ? 421 MET B CG 1 ATOM 2964 S SD . MET B 2 41 ? -37.448 -30.012 -6.440 1.00 26.11 ? 421 MET B SD 1 ATOM 2965 C CE . MET B 2 41 ? -38.139 -30.612 -4.906 1.00 30.06 ? 421 MET B CE 1 ATOM 2966 N N . ASP B 2 42 ? -32.265 -32.040 -5.108 1.00 26.07 ? 422 ASP B N 1 ATOM 2967 C CA . ASP B 2 42 ? -31.187 -32.406 -4.182 1.00 28.55 ? 422 ASP B CA 1 ATOM 2968 C C . ASP B 2 42 ? -30.462 -31.194 -3.595 1.00 29.01 ? 422 ASP B C 1 ATOM 2969 O O . ASP B 2 42 ? -29.828 -31.332 -2.577 1.00 28.81 ? 422 ASP B O 1 ATOM 2970 C CB . ASP B 2 42 ? -30.167 -33.295 -4.909 1.00 32.77 ? 422 ASP B CB 1 ATOM 2971 C CG . ASP B 2 42 ? -28.968 -33.684 -4.036 1.00 37.74 ? 422 ASP B CG 1 ATOM 2972 O OD1 . ASP B 2 42 ? -29.188 -34.390 -3.048 1.00 36.90 ? 422 ASP B OD1 1 ATOM 2973 O OD2 . ASP B 2 42 ? -27.818 -33.287 -4.356 1.00 44.39 ? 422 ASP B OD2 1 ATOM 2974 N N . ASP B 2 43 ? -30.547 -30.011 -4.221 1.00 28.35 ? 423 ASP B N 1 ATOM 2975 C CA . ASP B 2 43 ? -29.901 -28.826 -3.669 1.00 27.38 ? 423 ASP B CA 1 ATOM 2976 C C . ASP B 2 43 ? -30.688 -28.231 -2.507 1.00 27.74 ? 423 ASP B C 1 ATOM 2977 O O . ASP B 2 43 ? -30.174 -27.370 -1.800 1.00 25.95 ? 423 ASP B O 1 ATOM 2978 C CB . ASP B 2 43 ? -29.675 -27.742 -4.730 1.00 28.74 ? 423 ASP B CB 1 ATOM 2979 C CG . ASP B 2 43 ? -28.404 -27.973 -5.561 1.00 32.39 ? 423 ASP B CG 1 ATOM 2980 O OD1 . ASP B 2 43 ? -27.639 -28.904 -5.217 1.00 31.94 ? 423 ASP B OD1 1 ATOM 2981 O OD2 . ASP B 2 43 ? -28.173 -27.210 -6.549 1.00 32.28 ? 423 ASP B OD2 1 ATOM 2982 N N . PHE B 2 44 ? -31.930 -28.655 -2.301 1.00 25.78 ? 424 PHE B N 1 ATOM 2983 C CA . PHE B 2 44 ? -32.636 -28.220 -1.091 1.00 25.46 ? 424 PHE B CA 1 ATOM 2984 C C . PHE B 2 44 ? -32.073 -28.945 0.109 1.00 25.65 ? 424 PHE B C 1 ATOM 2985 O O . PHE B 2 44 ? -31.480 -30.006 -0.010 1.00 26.60 ? 424 PHE B O 1 ATOM 2986 C CB . PHE B 2 44 ? -34.130 -28.502 -1.166 1.00 24.86 ? 424 PHE B CB 1 ATOM 2987 C CG . PHE B 2 44 ? -34.880 -27.585 -2.097 1.00 24.25 ? 424 PHE B CG 1 ATOM 2988 C CD1 . PHE B 2 44 ? -35.167 -26.280 -1.732 1.00 23.76 ? 424 PHE B CD1 1 ATOM 2989 C CD2 . PHE B 2 44 ? -35.321 -28.037 -3.326 1.00 24.17 ? 424 PHE B CD2 1 ATOM 2990 C CE1 . PHE B 2 44 ? -35.849 -25.439 -2.581 1.00 23.63 ? 424 PHE B CE1 1 ATOM 2991 C CE2 . PHE B 2 44 ? -36.023 -27.192 -4.178 1.00 24.05 ? 424 PHE B CE2 1 ATOM 2992 C CZ . PHE B 2 44 ? -36.300 -25.906 -3.797 1.00 24.04 ? 424 PHE B CZ 1 ATOM 2993 N N . SER B 2 45 ? -32.251 -28.335 1.257 1.00 27.30 ? 425 SER B N 1 ATOM 2994 C CA . SER B 2 45 ? -32.048 -28.993 2.543 1.00 32.18 ? 425 SER B CA 1 ATOM 2995 C C . SER B 2 45 ? -33.336 -29.713 2.937 1.00 34.25 ? 425 SER B C 1 ATOM 2996 O O . SER B 2 45 ? -34.429 -29.223 2.635 1.00 32.95 ? 425 SER B O 1 ATOM 2997 C CB . SER B 2 45 ? -31.754 -27.915 3.590 1.00 33.63 ? 425 SER B CB 1 ATOM 2998 O OG . SER B 2 45 ? -31.196 -28.495 4.742 1.00 40.99 ? 425 SER B OG 1 ATOM 2999 N N . SER B 2 46 ? -33.227 -30.855 3.600 1.00 37.62 ? 426 SER B N 1 ATOM 3000 C CA . SER B 2 46 ? -34.415 -31.602 4.056 1.00 46.92 ? 426 SER B CA 1 ATOM 3001 C C . SER B 2 46 ? -34.263 -31.837 5.563 1.00 52.80 ? 426 SER B C 1 ATOM 3002 O O . SER B 2 46 ? -33.193 -32.214 6.008 1.00 57.83 ? 426 SER B O 1 ATOM 3003 C CB . SER B 2 46 ? -34.573 -32.948 3.300 1.00 49.54 ? 426 SER B CB 1 ATOM 3004 O OG . SER B 2 46 ? -34.822 -32.801 1.880 1.00 51.46 ? 426 SER B OG 1 ATOM 3005 N N . PRO B 2 47 ? -35.321 -31.606 6.362 1.00 57.52 ? 427 PRO B N 1 ATOM 3006 C CA . PRO B 2 47 ? -35.171 -31.770 7.826 1.00 60.22 ? 427 PRO B CA 1 ATOM 3007 C C . PRO B 2 47 ? -34.844 -33.189 8.298 1.00 65.29 ? 427 PRO B C 1 ATOM 3008 O O . PRO B 2 47 ? -34.145 -33.354 9.291 1.00 65.78 ? 427 PRO B O 1 ATOM 3009 C CB . PRO B 2 47 ? -36.526 -31.321 8.379 1.00 57.81 ? 427 PRO B CB 1 ATOM 3010 C CG . PRO B 2 47 ? -37.472 -31.453 7.231 1.00 57.77 ? 427 PRO B CG 1 ATOM 3011 C CD . PRO B 2 47 ? -36.678 -31.178 5.990 1.00 55.62 ? 427 PRO B CD 1 ATOM 3012 N N . SER B 2 48 ? -35.313 -34.205 7.584 1.00 77.91 ? 428 SER B N 1 ATOM 3013 C CA . SER B 2 48 ? -35.087 -35.586 8.014 1.00 87.22 ? 428 SER B CA 1 ATOM 3014 C C . SER B 2 48 ? -33.828 -36.262 7.428 1.00 93.90 ? 428 SER B C 1 ATOM 3015 O O . SER B 2 48 ? -33.511 -37.388 7.811 1.00 102.05 ? 428 SER B O 1 ATOM 3016 C CB . SER B 2 48 ? -36.334 -36.435 7.734 1.00 89.43 ? 428 SER B CB 1 ATOM 3017 O OG . SER B 2 48 ? -36.506 -36.667 6.352 1.00 87.98 ? 428 SER B OG 1 ATOM 3018 N N . ILE B 2 49 ? -33.107 -35.598 6.526 1.00 93.95 ? 429 ILE B N 1 ATOM 3019 C CA . ILE B 2 49 ? -31.880 -36.179 5.961 1.00 95.86 ? 429 ILE B CA 1 ATOM 3020 C C . ILE B 2 49 ? -30.639 -35.670 6.712 1.00 98.52 ? 429 ILE B C 1 ATOM 3021 O O . ILE B 2 49 ? -30.418 -34.458 6.820 1.00 94.04 ? 429 ILE B O 1 ATOM 3022 C CB . ILE B 2 49 ? -31.740 -35.888 4.435 1.00 97.59 ? 429 ILE B CB 1 ATOM 3023 C CG1 . ILE B 2 49 ? -32.944 -36.450 3.652 1.00 97.21 ? 429 ILE B CG1 1 ATOM 3024 C CG2 . ILE B 2 49 ? -30.437 -36.471 3.882 1.00 92.06 ? 429 ILE B CG2 1 ATOM 3025 C CD1 . ILE B 2 49 ? -32.984 -36.059 2.182 1.00 95.46 ? 429 ILE B CD1 1 ATOM 3026 N N . THR B 2 50 ? -29.843 -36.608 7.232 1.00 105.31 ? 430 THR B N 1 ATOM 3027 C CA . THR B 2 50 ? -28.528 -36.307 7.817 1.00 110.94 ? 430 THR B CA 1 ATOM 3028 C C . THR B 2 50 ? -27.499 -36.133 6.709 1.00 114.77 ? 430 THR B C 1 ATOM 3029 O O . THR B 2 50 ? -26.934 -37.118 6.222 1.00 112.37 ? 430 THR B O 1 ATOM 3030 C CB . THR B 2 50 ? -28.035 -37.452 8.722 1.00 112.56 ? 430 THR B CB 1 ATOM 3031 O OG1 . THR B 2 50 ? -28.963 -37.649 9.796 1.00 113.98 ? 430 THR B OG1 1 ATOM 3032 C CG2 . THR B 2 50 ? -26.624 -37.152 9.278 1.00 108.63 ? 430 THR B CG2 1 ATOM 3033 N N . ASN B 2 51 ? -27.242 -34.891 6.317 1.00 115.31 ? 431 ASN B N 1 ATOM 3034 C CA . ASN B 2 51 ? -26.410 -34.647 5.144 1.00 117.72 ? 431 ASN B CA 1 ATOM 3035 C C . ASN B 2 51 ? -24.961 -35.088 5.372 1.00 117.71 ? 431 ASN B C 1 ATOM 3036 O O . ASN B 2 51 ? -24.432 -35.941 4.651 1.00 118.92 ? 431 ASN B O 1 ATOM 3037 C CB . ASN B 2 51 ? -26.473 -33.169 4.730 1.00 116.06 ? 431 ASN B CB 1 ATOM 3038 C CG . ASN B 2 51 ? -26.026 -32.948 3.296 1.00 113.53 ? 431 ASN B CG 1 ATOM 3039 O OD1 . ASN B 2 51 ? -25.933 -33.895 2.512 1.00 111.50 ? 431 ASN B OD1 1 ATOM 3040 N ND2 . ASN B 2 51 ? -25.751 -31.697 2.946 1.00 108.70 ? 431 ASN B ND2 1 ATOM 3041 N N . GLU B 2 52 ? -24.342 -34.501 6.390 1.00 110.01 ? 432 GLU B N 1 ATOM 3042 C CA . GLU B 2 52 ? -22.958 -34.776 6.745 1.00 99.98 ? 432 GLU B CA 1 ATOM 3043 C C . GLU B 2 52 ? -22.920 -34.989 8.250 1.00 85.30 ? 432 GLU B C 1 ATOM 3044 O O . GLU B 2 52 ? -23.783 -34.485 8.974 1.00 72.60 ? 432 GLU B O 1 ATOM 3045 C CB . GLU B 2 52 ? -22.056 -33.585 6.382 1.00 104.53 ? 432 GLU B CB 1 ATOM 3046 C CG . GLU B 2 52 ? -21.927 -33.262 4.899 1.00 109.13 ? 432 GLU B CG 1 ATOM 3047 C CD . GLU B 2 52 ? -21.401 -34.432 4.101 1.00 115.63 ? 432 GLU B CD 1 ATOM 3048 O OE1 . GLU B 2 52 ? -20.486 -35.121 4.613 1.00 120.15 ? 432 GLU B OE1 1 ATOM 3049 O OE2 . GLU B 2 52 ? -21.898 -34.656 2.971 1.00 121.03 ? 432 GLU B OE2 1 ATOM 3050 N N . PHE B 2 53 ? -21.914 -35.719 8.716 1.00 74.50 ? 433 PHE B N 1 ATOM 3051 C CA . PHE B 2 53 ? -21.701 -35.912 10.143 1.00 71.79 ? 433 PHE B CA 1 ATOM 3052 C C . PHE B 2 53 ? -21.578 -34.553 10.844 1.00 68.73 ? 433 PHE B C 1 ATOM 3053 O O . PHE B 2 53 ? -20.712 -33.738 10.509 1.00 59.76 ? 433 PHE B O 1 ATOM 3054 C CB . PHE B 2 53 ? -20.445 -36.756 10.395 1.00 76.37 ? 433 PHE B CB 1 ATOM 3055 C CG . PHE B 2 53 ? -20.124 -36.948 11.854 1.00 79.59 ? 433 PHE B CG 1 ATOM 3056 C CD1 . PHE B 2 53 ? -20.689 -38.002 12.571 1.00 77.60 ? 433 PHE B CD1 1 ATOM 3057 C CD2 . PHE B 2 53 ? -19.261 -36.069 12.518 1.00 79.10 ? 433 PHE B CD2 1 ATOM 3058 C CE1 . PHE B 2 53 ? -20.400 -38.178 13.919 1.00 75.34 ? 433 PHE B CE1 1 ATOM 3059 C CE2 . PHE B 2 53 ? -18.969 -36.244 13.864 1.00 75.53 ? 433 PHE B CE2 1 ATOM 3060 C CZ . PHE B 2 53 ? -19.538 -37.300 14.562 1.00 74.27 ? 433 PHE B CZ 1 ATOM 3061 N N . GLY B 2 54 ? -22.473 -34.314 11.801 1.00 69.59 ? 434 GLY B N 1 ATOM 3062 C CA . GLY B 2 54 ? -22.499 -33.067 12.561 1.00 66.79 ? 434 GLY B CA 1 ATOM 3063 C C . GLY B 2 54 ? -23.022 -31.833 11.834 1.00 62.41 ? 434 GLY B C 1 ATOM 3064 O O . GLY B 2 54 ? -22.943 -30.720 12.375 1.00 55.58 ? 434 GLY B O 1 ATOM 3065 N N . VAL B 2 55 ? -23.551 -32.010 10.618 1.00 57.04 ? 435 VAL B N 1 ATOM 3066 C CA . VAL B 2 55 ? -24.113 -30.881 9.853 1.00 56.37 ? 435 VAL B CA 1 ATOM 3067 C C . VAL B 2 55 ? -25.640 -30.948 9.881 1.00 55.52 ? 435 VAL B C 1 ATOM 3068 O O . VAL B 2 55 ? -26.234 -31.890 9.335 1.00 54.76 ? 435 VAL B O 1 ATOM 3069 C CB . VAL B 2 55 ? -23.626 -30.828 8.388 1.00 53.95 ? 435 VAL B CB 1 ATOM 3070 C CG1 . VAL B 2 55 ? -24.206 -29.599 7.677 1.00 52.83 ? 435 VAL B CG1 1 ATOM 3071 C CG2 . VAL B 2 55 ? -22.106 -30.816 8.354 1.00 54.74 ? 435 VAL B CG2 1 ATOM 3072 N N . PRO B 2 56 ? -26.279 -29.956 10.537 1.00 52.01 ? 436 PRO B N 1 ATOM 3073 C CA . PRO B 2 56 ? -27.728 -29.932 10.522 1.00 51.86 ? 436 PRO B CA 1 ATOM 3074 C C . PRO B 2 56 ? -28.314 -29.362 9.215 1.00 50.41 ? 436 PRO B C 1 ATOM 3075 O O . PRO B 2 56 ? -27.570 -28.854 8.354 1.00 46.67 ? 436 PRO B O 1 ATOM 3076 C CB . PRO B 2 56 ? -28.080 -29.042 11.719 1.00 49.62 ? 436 PRO B CB 1 ATOM 3077 C CG . PRO B 2 56 ? -26.898 -28.175 11.933 1.00 50.59 ? 436 PRO B CG 1 ATOM 3078 C CD . PRO B 2 56 ? -25.713 -28.793 11.247 1.00 49.87 ? 436 PRO B CD 1 ATOM 3079 N N . PRO B 2 57 ? -29.641 -29.492 9.059 1.00 49.23 ? 437 PRO B N 1 ATOM 3080 C CA . PRO B 2 57 ? -30.384 -28.846 7.998 1.00 49.10 ? 437 PRO B CA 1 ATOM 3081 C C . PRO B 2 57 ? -30.314 -27.340 8.086 1.00 49.75 ? 437 PRO B C 1 ATOM 3082 O O . PRO B 2 57 ? -30.098 -26.792 9.174 1.00 51.02 ? 437 PRO B O 1 ATOM 3083 C CB . PRO B 2 57 ? -31.831 -29.293 8.247 1.00 51.14 ? 437 PRO B CB 1 ATOM 3084 C CG . PRO B 2 57 ? -31.858 -29.966 9.570 1.00 54.37 ? 437 PRO B CG 1 ATOM 3085 C CD . PRO B 2 57 ? -30.467 -30.485 9.774 1.00 52.34 ? 437 PRO B CD 1 ATOM 3086 N N . SER B 2 58 ? -30.519 -26.691 6.941 1.00 44.70 ? 438 SER B N 1 ATOM 3087 C CA . SER B 2 58 ? -30.672 -25.247 6.868 1.00 43.04 ? 438 SER B CA 1 ATOM 3088 C C . SER B 2 58 ? -32.126 -24.902 6.547 1.00 41.20 ? 438 SER B C 1 ATOM 3089 O O . SER B 2 58 ? -32.562 -25.061 5.414 1.00 35.69 ? 438 SER B O 1 ATOM 3090 C CB . SER B 2 58 ? -29.740 -24.689 5.807 1.00 40.43 ? 438 SER B CB 1 ATOM 3091 O OG . SER B 2 58 ? -28.434 -25.128 6.076 1.00 42.67 ? 438 SER B OG 1 ATOM 3092 N N . PRO B 2 59 ? -32.894 -24.446 7.555 1.00 43.12 ? 439 PRO B N 1 ATOM 3093 C CA . PRO B 2 59 ? -34.316 -24.126 7.329 1.00 41.89 ? 439 PRO B CA 1 ATOM 3094 C C . PRO B 2 59 ? -34.595 -23.083 6.271 1.00 35.81 ? 439 PRO B C 1 ATOM 3095 O O . PRO B 2 59 ? -35.620 -23.180 5.581 1.00 38.81 ? 439 PRO B O 1 ATOM 3096 C CB . PRO B 2 59 ? -34.798 -23.646 8.701 1.00 45.64 ? 439 PRO B CB 1 ATOM 3097 C CG . PRO B 2 59 ? -33.919 -24.371 9.669 1.00 45.54 ? 439 PRO B CG 1 ATOM 3098 C CD . PRO B 2 59 ? -32.592 -24.599 8.991 1.00 45.90 ? 439 PRO B CD 1 ATOM 3099 N N . ALA B 2 60 ? -33.684 -22.132 6.080 1.00 31.45 ? 440 ALA B N 1 ATOM 3100 C CA . ALA B 2 60 ? -33.847 -21.189 4.989 1.00 28.59 ? 440 ALA B CA 1 ATOM 3101 C C . ALA B 2 60 ? -33.892 -21.887 3.601 1.00 27.22 ? 440 ALA B C 1 ATOM 3102 O O . ALA B 2 60 ? -34.415 -21.308 2.669 1.00 25.53 ? 440 ALA B O 1 ATOM 3103 C CB . ALA B 2 60 ? -32.766 -20.137 5.016 1.00 29.42 ? 440 ALA B CB 1 ATOM 3104 N N . ASN B 2 61 ? -33.343 -23.104 3.482 1.00 25.70 ? 441 ASN B N 1 ATOM 3105 C CA . ASN B 2 61 ? -33.237 -23.813 2.195 1.00 26.13 ? 441 ASN B CA 1 ATOM 3106 C C . ASN B 2 61 ? -34.093 -25.080 2.098 1.00 25.81 ? 441 ASN B C 1 ATOM 3107 O O . ASN B 2 61 ? -33.774 -25.978 1.316 1.00 23.73 ? 441 ASN B O 1 ATOM 3108 C CB . ASN B 2 61 ? -31.754 -24.152 1.885 1.00 25.50 ? 441 ASN B CB 1 ATOM 3109 C CG . ASN B 2 61 ? -31.530 -24.581 0.418 1.00 24.62 ? 441 ASN B CG 1 ATOM 3110 O OD1 . ASN B 2 61 ? -32.179 -24.067 -0.499 1.00 22.55 ? 441 ASN B OD1 1 ATOM 3111 N ND2 . ASN B 2 61 ? -30.634 -25.544 0.203 1.00 22.43 ? 441 ASN B ND2 1 ATOM 3112 N N . PHE B 2 62 ? -35.157 -25.151 2.908 1.00 26.94 ? 442 PHE B N 1 ATOM 3113 C CA . PHE B 2 62 ? -36.126 -26.232 2.835 1.00 29.46 ? 442 PHE B CA 1 ATOM 3114 C C . PHE B 2 62 ? -37.000 -26.086 1.580 1.00 28.03 ? 442 PHE B C 1 ATOM 3115 O O . PHE B 2 62 ? -37.223 -24.987 1.070 1.00 24.62 ? 442 PHE B O 1 ATOM 3116 C CB . PHE B 2 62 ? -37.062 -26.266 4.074 1.00 32.13 ? 442 PHE B CB 1 ATOM 3117 C CG . PHE B 2 62 ? -36.421 -26.771 5.352 1.00 37.06 ? 442 PHE B CG 1 ATOM 3118 C CD1 . PHE B 2 62 ? -35.216 -27.476 5.350 1.00 37.58 ? 442 PHE B CD1 1 ATOM 3119 C CD2 . PHE B 2 62 ? -37.052 -26.542 6.584 1.00 40.32 ? 442 PHE B CD2 1 ATOM 3120 C CE1 . PHE B 2 62 ? -34.652 -27.937 6.535 1.00 39.03 ? 442 PHE B CE1 1 ATOM 3121 C CE2 . PHE B 2 62 ? -36.490 -27.000 7.776 1.00 40.92 ? 442 PHE B CE2 1 ATOM 3122 C CZ . PHE B 2 62 ? -35.287 -27.706 7.748 1.00 41.91 ? 442 PHE B CZ 1 ATOM 3123 N N . ILE B 2 63 ? -37.531 -27.220 1.146 1.00 27.11 ? 443 ILE B N 1 ATOM 3124 C CA . ILE B 2 63 ? -38.395 -27.289 -0.014 1.00 27.10 ? 443 ILE B CA 1 ATOM 3125 C C . ILE B 2 63 ? -39.734 -26.630 0.279 1.00 26.84 ? 443 ILE B C 1 ATOM 3126 O O . ILE B 2 63 ? -40.351 -26.943 1.269 1.00 27.15 ? 443 ILE B O 1 ATOM 3127 C CB . ILE B 2 63 ? -38.659 -28.768 -0.414 1.00 27.57 ? 443 ILE B CB 1 ATOM 3128 C CG1 . ILE B 2 63 ? -37.358 -29.463 -0.828 1.00 26.35 ? 443 ILE B CG1 1 ATOM 3129 C CG2 . ILE B 2 63 ? -39.688 -28.847 -1.540 1.00 27.93 ? 443 ILE B CG2 1 ATOM 3130 C CD1 . ILE B 2 63 ? -37.409 -30.967 -0.823 1.00 26.62 ? 443 ILE B CD1 1 ATOM 3131 N N . GLN B 2 64 ? -40.129 -25.683 -0.561 1.00 28.77 ? 444 GLN B N 1 ATOM 3132 C CA A GLN B 2 64 ? -41.519 -25.237 -0.643 0.50 30.45 ? 444 GLN B CA 1 ATOM 3133 C CA B GLN B 2 64 ? -41.502 -25.202 -0.625 0.50 30.65 ? 444 GLN B CA 1 ATOM 3134 C C . GLN B 2 64 ? -41.902 -25.242 -2.118 1.00 31.92 ? 444 GLN B C 1 ATOM 3135 O O . GLN B 2 64 ? -41.024 -25.109 -2.999 1.00 32.05 ? 444 GLN B O 1 ATOM 3136 C CB A GLN B 2 64 ? -41.728 -23.842 -0.050 0.50 31.32 ? 444 GLN B CB 1 ATOM 3137 C CB B GLN B 2 64 ? -41.613 -23.794 0.002 0.50 32.15 ? 444 GLN B CB 1 ATOM 3138 C CG A GLN B 2 64 ? -41.464 -23.724 1.454 0.50 31.96 ? 444 GLN B CG 1 ATOM 3139 C CG B GLN B 2 64 ? -41.091 -23.708 1.459 0.50 32.65 ? 444 GLN B CG 1 ATOM 3140 C CD A GLN B 2 64 ? -42.323 -24.656 2.288 0.50 32.54 ? 444 GLN B CD 1 ATOM 3141 C CD B GLN B 2 64 ? -40.935 -22.290 2.016 0.50 34.20 ? 444 GLN B CD 1 ATOM 3142 O OE1 A GLN B 2 64 ? -43.444 -25.012 1.914 0.50 34.99 ? 444 GLN B OE1 1 ATOM 3143 O OE1 B GLN B 2 64 ? -39.815 -21.866 2.388 0.50 35.10 ? 444 GLN B OE1 1 ATOM 3144 N NE2 A GLN B 2 64 ? -41.796 -25.059 3.422 0.50 33.41 ? 444 GLN B NE2 1 ATOM 3145 N NE2 B GLN B 2 64 ? -42.058 -21.561 2.133 0.50 33.20 ? 444 GLN B NE2 1 ATOM 3146 N N . PRO B 2 65 ? -43.212 -25.448 -2.425 1.00 30.64 ? 445 PRO B N 1 ATOM 3147 C CA . PRO B 2 65 ? -43.600 -25.410 -3.850 1.00 29.84 ? 445 PRO B CA 1 ATOM 3148 C C . PRO B 2 65 ? -43.353 -24.042 -4.459 1.00 28.34 ? 445 PRO B C 1 ATOM 3149 O O . PRO B 2 65 ? -43.725 -23.043 -3.858 1.00 28.09 ? 445 PRO B O 1 ATOM 3150 C CB . PRO B 2 65 ? -45.123 -25.681 -3.821 1.00 31.51 ? 445 PRO B CB 1 ATOM 3151 C CG . PRO B 2 65 ? -45.540 -25.383 -2.402 1.00 31.92 ? 445 PRO B CG 1 ATOM 3152 C CD . PRO B 2 65 ? -44.363 -25.782 -1.559 1.00 30.64 ? 445 PRO B CD 1 ATOM 3153 N N . GLY B 2 66 ? -42.752 -24.005 -5.651 1.00 26.89 ? 446 GLY B N 1 ATOM 3154 C CA . GLY B 2 66 ? -42.406 -22.749 -6.312 1.00 25.83 ? 446 GLY B CA 1 ATOM 3155 C C . GLY B 2 66 ? -41.091 -22.106 -5.872 1.00 26.85 ? 446 GLY B C 1 ATOM 3156 O O . GLY B 2 66 ? -40.708 -21.056 -6.406 1.00 28.61 ? 446 GLY B O 1 ATOM 3157 N N . LYS B 2 67 ? -40.396 -22.705 -4.903 1.00 25.97 ? 447 LYS B N 1 ATOM 3158 C CA . LYS B 2 67 ? -39.152 -22.138 -4.364 1.00 25.28 ? 447 LYS B CA 1 ATOM 3159 C C . LYS B 2 67 ? -37.968 -22.645 -5.179 1.00 23.44 ? 447 LYS B C 1 ATOM 3160 O O . LYS B 2 67 ? -38.012 -23.738 -5.699 1.00 21.45 ? 447 LYS B O 1 ATOM 3161 C CB . LYS B 2 67 ? -38.963 -22.590 -2.917 1.00 26.73 ? 447 LYS B CB 1 ATOM 3162 C CG . LYS B 2 67 ? -37.960 -21.785 -2.094 1.00 27.80 ? 447 LYS B CG 1 ATOM 3163 C CD . LYS B 2 67 ? -37.919 -22.357 -0.682 1.00 27.76 ? 447 LYS B CD 1 ATOM 3164 C CE . LYS B 2 67 ? -36.979 -21.604 0.225 1.00 27.93 ? 447 LYS B CE 1 ATOM 3165 N NZ . LYS B 2 67 ? -36.794 -22.351 1.478 1.00 27.86 ? 447 LYS B NZ 1 ATOM 3166 N N . GLN B 2 68 ? -36.925 -21.826 -5.308 1.00 22.55 ? 448 GLN B N 1 ATOM 3167 C CA . GLN B 2 68 ? -35.678 -22.240 -5.961 1.00 21.74 ? 448 GLN B CA 1 ATOM 3168 C C . GLN B 2 68 ? -34.651 -22.645 -4.903 1.00 21.75 ? 448 GLN B C 1 ATOM 3169 O O . GLN B 2 68 ? -34.488 -21.944 -3.883 1.00 22.81 ? 448 GLN B O 1 ATOM 3170 C CB . GLN B 2 68 ? -35.123 -21.093 -6.796 1.00 21.98 ? 448 GLN B CB 1 ATOM 3171 C CG . GLN B 2 68 ? -36.058 -20.608 -7.893 1.00 23.22 ? 448 GLN B CG 1 ATOM 3172 C CD . GLN B 2 68 ? -35.448 -19.494 -8.729 1.00 22.70 ? 448 GLN B CD 1 ATOM 3173 O OE1 . GLN B 2 68 ? -35.035 -18.466 -8.199 1.00 23.59 ? 448 GLN B OE1 1 ATOM 3174 N NE2 . GLN B 2 68 ? -35.365 -19.707 -10.041 1.00 23.75 ? 448 GLN B NE2 1 ATOM 3175 N N . PRO B 2 69 ? -33.960 -23.765 -5.114 1.00 20.49 ? 449 PRO B N 1 ATOM 3176 C CA . PRO B 2 69 ? -32.929 -24.192 -4.153 1.00 20.84 ? 449 PRO B CA 1 ATOM 3177 C C . PRO B 2 69 ? -31.667 -23.330 -4.179 1.00 22.46 ? 449 PRO B C 1 ATOM 3178 O O . PRO B 2 69 ? -31.338 -22.748 -5.204 1.00 22.30 ? 449 PRO B O 1 ATOM 3179 C CB . PRO B 2 69 ? -32.606 -25.625 -4.604 1.00 21.19 ? 449 PRO B CB 1 ATOM 3180 C CG . PRO B 2 69 ? -32.974 -25.675 -6.048 1.00 20.31 ? 449 PRO B CG 1 ATOM 3181 C CD . PRO B 2 69 ? -34.119 -24.719 -6.220 1.00 19.89 ? 449 PRO B CD 1 ATOM 3182 N N . LEU B 2 70 ? -30.989 -23.227 -3.029 1.00 24.06 ? 450 LEU B N 1 ATOM 3183 C CA . LEU B 2 70 ? -29.737 -22.494 -2.915 1.00 24.25 ? 450 LEU B CA 1 ATOM 3184 C C . LEU B 2 70 ? -28.713 -23.116 -3.890 1.00 24.57 ? 450 LEU B C 1 ATOM 3185 O O . LEU B 2 70 ? -28.743 -24.315 -4.128 1.00 23.47 ? 450 LEU B O 1 ATOM 3186 C CB . LEU B 2 70 ? -29.249 -22.539 -1.473 1.00 26.35 ? 450 LEU B CB 1 ATOM 3187 C CG . LEU B 2 70 ? -28.011 -21.724 -1.105 1.00 28.84 ? 450 LEU B CG 1 ATOM 3188 C CD1 . LEU B 2 70 ? -28.228 -20.228 -1.250 1.00 32.97 ? 450 LEU B CD1 1 ATOM 3189 C CD2 . LEU B 2 70 ? -27.566 -22.040 0.293 1.00 29.08 ? 450 LEU B CD2 1 ATOM 3190 N N . SER B 2 71 ? -27.854 -22.275 -4.476 1.00 23.91 ? 451 SER B N 1 ATOM 3191 C CA . SER B 2 71 ? -26.817 -22.695 -5.422 1.00 23.01 ? 451 SER B CA 1 ATOM 3192 C C . SER B 2 71 ? -25.478 -22.053 -5.108 1.00 24.00 ? 451 SER B C 1 ATOM 3193 O O . SER B 2 71 ? -25.403 -20.907 -4.615 1.00 24.13 ? 451 SER B O 1 ATOM 3194 C CB . SER B 2 71 ? -27.212 -22.275 -6.839 1.00 23.34 ? 451 SER B CB 1 ATOM 3195 O OG . SER B 2 71 ? -26.208 -22.550 -7.788 1.00 21.17 ? 451 SER B OG 1 ATOM 3196 N N . SER B 2 72 ? -24.412 -22.783 -5.425 1.00 23.34 ? 452 SER B N 1 ATOM 3197 C CA . SER B 2 72 ? -23.061 -22.279 -5.291 1.00 22.95 ? 452 SER B CA 1 ATOM 3198 C C . SER B 2 72 ? -22.628 -21.470 -6.514 1.00 23.28 ? 452 SER B C 1 ATOM 3199 O O . SER B 2 72 ? -21.567 -20.813 -6.509 1.00 24.74 ? 452 SER B O 1 ATOM 3200 C CB . SER B 2 72 ? -22.130 -23.442 -5.055 1.00 24.07 ? 452 SER B CB 1 ATOM 3201 O OG . SER B 2 72 ? -22.543 -24.137 -3.891 1.00 23.13 ? 452 SER B OG 1 ATOM 3202 N N . MET B 2 73 ? -23.440 -21.513 -7.568 1.00 23.62 ? 453 MET B N 1 ATOM 3203 C CA A MET B 2 73 ? -23.136 -20.819 -8.827 0.50 23.69 ? 453 MET B CA 1 ATOM 3204 C CA B MET B 2 73 ? -23.117 -20.807 -8.812 0.50 23.94 ? 453 MET B CA 1 ATOM 3205 C C . MET B 2 73 ? -22.939 -19.314 -8.572 1.00 23.44 ? 453 MET B C 1 ATOM 3206 O O . MET B 2 73 ? -23.611 -18.729 -7.714 1.00 22.65 ? 453 MET B O 1 ATOM 3207 C CB A MET B 2 73 ? -24.256 -21.045 -9.879 0.50 23.26 ? 453 MET B CB 1 ATOM 3208 C CB B MET B 2 73 ? -24.214 -21.001 -9.856 0.50 23.91 ? 453 MET B CB 1 ATOM 3209 C CG A MET B 2 73 ? -24.408 -22.475 -10.415 0.50 22.91 ? 453 MET B CG 1 ATOM 3210 C CG B MET B 2 73 ? -24.235 -22.356 -10.524 0.50 23.74 ? 453 MET B CG 1 ATOM 3211 S SD A MET B 2 73 ? -25.733 -22.749 -11.639 0.50 23.43 ? 453 MET B SD 1 ATOM 3212 S SD B MET B 2 73 ? -25.262 -22.228 -11.996 0.50 25.18 ? 453 MET B SD 1 ATOM 3213 C CE A MET B 2 73 ? -27.207 -22.225 -10.763 0.60 21.37 ? 453 MET B CE 1 ATOM 3214 C CE B MET B 2 73 ? -25.204 -23.886 -12.603 0.40 23.13 ? 453 MET B CE 1 ATOM 3215 N N . CYS B 2 74 ? -22.036 -18.701 -9.344 1.00 23.37 ? 454 CYS B N 1 ATOM 3216 C CA A CYS B 2 74 ? -21.797 -17.269 -9.234 0.50 22.94 ? 454 CYS B CA 1 ATOM 3217 C CA B CYS B 2 74 ? -21.723 -17.308 -9.210 0.50 24.22 ? 454 CYS B CA 1 ATOM 3218 C C . CYS B 2 74 ? -21.113 -16.681 -10.475 1.00 23.13 ? 454 CYS B C 1 ATOM 3219 O O . CYS B 2 74 ? -19.987 -16.192 -10.428 1.00 23.61 ? 454 CYS B O 1 ATOM 3220 C CB A CYS B 2 74 ? -21.020 -16.945 -7.965 0.50 22.68 ? 454 CYS B CB 1 ATOM 3221 C CB B CYS B 2 74 ? -20.761 -17.138 -8.038 0.50 25.25 ? 454 CYS B CB 1 ATOM 3222 S SG A CYS B 2 74 ? -19.487 -17.843 -7.838 0.50 21.60 ? 454 CYS B SG 1 ATOM 3223 S SG B CYS B 2 74 ? -20.733 -15.432 -7.464 0.50 29.17 ? 454 CYS B SG 1 ATOM 3224 N N . PRO B 2 75 ? -21.833 -16.699 -11.597 1.00 21.97 ? 455 PRO B N 1 ATOM 3225 C CA . PRO B 2 75 ? -21.343 -16.065 -12.813 1.00 22.41 ? 455 PRO B CA 1 ATOM 3226 C C . PRO B 2 75 ? -21.163 -14.541 -12.636 1.00 22.62 ? 455 PRO B C 1 ATOM 3227 O O . PRO B 2 75 ? -22.119 -13.817 -12.326 1.00 22.99 ? 455 PRO B O 1 ATOM 3228 C CB . PRO B 2 75 ? -22.444 -16.364 -13.851 1.00 22.00 ? 455 PRO B CB 1 ATOM 3229 C CG . PRO B 2 75 ? -23.663 -16.669 -13.055 1.00 21.78 ? 455 PRO B CG 1 ATOM 3230 C CD . PRO B 2 75 ? -23.161 -17.314 -11.797 1.00 22.65 ? 455 PRO B CD 1 ATOM 3231 N N . THR B 2 76 ? -19.950 -14.080 -12.893 1.00 21.54 ? 456 THR B N 1 ATOM 3232 C CA . THR B 2 76 ? -19.525 -12.758 -12.527 1.00 24.25 ? 456 THR B CA 1 ATOM 3233 C C . THR B 2 76 ? -18.949 -12.000 -13.744 1.00 24.18 ? 456 THR B C 1 ATOM 3234 O O . THR B 2 76 ? -18.327 -12.596 -14.640 1.00 24.50 ? 456 THR B O 1 ATOM 3235 C CB . THR B 2 76 ? -18.433 -12.913 -11.447 1.00 27.39 ? 456 THR B CB 1 ATOM 3236 O OG1 . THR B 2 76 ? -18.992 -13.550 -10.287 1.00 27.63 ? 456 THR B OG1 1 ATOM 3237 C CG2 . THR B 2 76 ? -17.832 -11.593 -11.061 1.00 30.52 ? 456 THR B CG2 1 ATOM 3238 N N . ILE B 2 77 ? -19.162 -10.695 -13.765 1.00 23.87 ? 457 ILE B N 1 ATOM 3239 C CA . ILE B 2 77 ? -18.536 -9.792 -14.725 1.00 23.29 ? 457 ILE B CA 1 ATOM 3240 C C . ILE B 2 77 ? -17.963 -8.615 -13.938 1.00 25.58 ? 457 ILE B C 1 ATOM 3241 O O . ILE B 2 77 ? -18.687 -7.914 -13.184 1.00 25.69 ? 457 ILE B O 1 ATOM 3242 C CB . ILE B 2 77 ? -19.550 -9.260 -15.740 1.00 23.31 ? 457 ILE B CB 1 ATOM 3243 C CG1 . ILE B 2 77 ? -20.214 -10.400 -16.503 1.00 22.98 ? 457 ILE B CG1 1 ATOM 3244 C CG2 . ILE B 2 77 ? -18.902 -8.328 -16.751 1.00 24.28 ? 457 ILE B CG2 1 ATOM 3245 C CD1 . ILE B 2 77 ? -21.251 -9.907 -17.512 1.00 23.34 ? 457 ILE B CD1 1 ATOM 3246 N N . MET B 2 78 ? -16.666 -8.401 -14.104 1.00 25.21 ? 458 MET B N 1 ATOM 3247 C CA . MET B 2 78 ? -15.996 -7.275 -13.495 1.00 27.53 ? 458 MET B CA 1 ATOM 3248 C C . MET B 2 78 ? -15.844 -6.193 -14.573 1.00 27.41 ? 458 MET B C 1 ATOM 3249 O O . MET B 2 78 ? -15.352 -6.478 -15.680 1.00 26.65 ? 458 MET B O 1 ATOM 3250 C CB . MET B 2 78 ? -14.637 -7.685 -12.947 1.00 27.74 ? 458 MET B CB 1 ATOM 3251 C CG . MET B 2 78 ? -13.861 -6.546 -12.271 1.00 30.06 ? 458 MET B CG 1 ATOM 3252 S SD . MET B 2 78 ? -12.115 -6.931 -11.967 1.00 33.09 ? 458 MET B SD 1 ATOM 3253 C CE . MET B 2 78 ? -12.245 -8.234 -10.765 1.00 33.39 ? 458 MET B CE 1 ATOM 3254 N N . VAL B 2 79 ? -16.270 -4.973 -14.227 1.00 26.55 ? 459 VAL B N 1 ATOM 3255 C CA . VAL B 2 79 ? -16.220 -3.815 -15.113 1.00 27.35 ? 459 VAL B CA 1 ATOM 3256 C C . VAL B 2 79 ? -15.389 -2.689 -14.475 1.00 26.85 ? 459 VAL B C 1 ATOM 3257 O O . VAL B 2 79 ? -15.530 -2.423 -13.295 1.00 26.09 ? 459 VAL B O 1 ATOM 3258 C CB . VAL B 2 79 ? -17.619 -3.265 -15.382 1.00 28.94 ? 459 VAL B CB 1 ATOM 3259 C CG1 . VAL B 2 79 ? -17.558 -2.127 -16.403 1.00 30.44 ? 459 VAL B CG1 1 ATOM 3260 C CG2 . VAL B 2 79 ? -18.562 -4.370 -15.851 1.00 29.64 ? 459 VAL B CG2 1 ATOM 3261 N N . GLY B 2 80 ? -14.547 -2.024 -15.275 1.00 27.04 ? 460 GLY B N 1 ATOM 3262 C CA . GLY B 2 80 ? -13.669 -0.959 -14.796 1.00 24.76 ? 460 GLY B CA 1 ATOM 3263 C C . GLY B 2 80 ? -14.450 0.339 -14.674 1.00 26.96 ? 460 GLY B C 1 ATOM 3264 O O . GLY B 2 80 ? -15.573 0.464 -15.194 1.00 25.71 ? 460 GLY B O 1 ATOM 3265 N N . GLN B 2 81 ? -13.862 1.312 -13.981 1.00 27.61 ? 461 GLN B N 1 ATOM 3266 C CA . GLN B 2 81 ? -14.537 2.594 -13.738 1.00 28.88 ? 461 GLN B CA 1 ATOM 3267 C C . GLN B 2 81 ? -14.894 3.314 -15.044 1.00 29.15 ? 461 GLN B C 1 ATOM 3268 O O . GLN B 2 81 ? -15.868 4.031 -15.093 1.00 29.68 ? 461 GLN B O 1 ATOM 3269 C CB . GLN B 2 81 ? -13.699 3.479 -12.798 1.00 28.94 ? 461 GLN B CB 1 ATOM 3270 C CG . GLN B 2 81 ? -12.272 3.768 -13.273 1.00 30.25 ? 461 GLN B CG 1 ATOM 3271 C CD . GLN B 2 81 ? -12.212 4.837 -14.360 1.00 31.48 ? 461 GLN B CD 1 ATOM 3272 O OE1 . GLN B 2 81 ? -13.155 5.631 -14.562 1.00 30.72 ? 461 GLN B OE1 1 ATOM 3273 N NE2 . GLN B 2 81 ? -11.096 4.869 -15.060 1.00 33.26 ? 461 GLN B NE2 1 ATOM 3274 N N . ASP B 2 82 ? -14.137 3.064 -16.101 1.00 29.88 ? 462 ASP B N 1 ATOM 3275 C CA . ASP B 2 82 ? -14.435 3.609 -17.440 1.00 33.04 ? 462 ASP B CA 1 ATOM 3276 C C . ASP B 2 82 ? -15.535 2.869 -18.231 1.00 34.09 ? 462 ASP B C 1 ATOM 3277 O O . ASP B 2 82 ? -15.789 3.183 -19.399 1.00 34.21 ? 462 ASP B O 1 ATOM 3278 C CB . ASP B 2 82 ? -13.135 3.699 -18.288 1.00 36.10 ? 462 ASP B CB 1 ATOM 3279 C CG . ASP B 2 82 ? -12.492 2.314 -18.589 1.00 38.45 ? 462 ASP B CG 1 ATOM 3280 O OD1 . ASP B 2 82 ? -13.032 1.261 -18.161 1.00 37.71 ? 462 ASP B OD1 1 ATOM 3281 O OD2 . ASP B 2 82 ? -11.434 2.288 -19.264 1.00 40.34 ? 462 ASP B OD2 1 ATOM 3282 N N . GLY B 2 83 ? -16.216 1.909 -17.615 1.00 30.66 ? 463 GLY B N 1 ATOM 3283 C CA . GLY B 2 83 ? -17.317 1.241 -18.298 1.00 28.66 ? 463 GLY B CA 1 ATOM 3284 C C . GLY B 2 83 ? -16.915 0.080 -19.189 1.00 28.74 ? 463 GLY B C 1 ATOM 3285 O O . GLY B 2 83 ? -17.765 -0.559 -19.802 1.00 28.40 ? 463 GLY B O 1 ATOM 3286 N N . GLN B 2 84 ? -15.631 -0.222 -19.260 1.00 28.88 ? 464 GLN B N 1 ATOM 3287 C CA . GLN B 2 84 ? -15.181 -1.345 -20.058 1.00 32.40 ? 464 GLN B CA 1 ATOM 3288 C C . GLN B 2 84 ? -14.979 -2.610 -19.210 1.00 30.09 ? 464 GLN B C 1 ATOM 3289 O O . GLN B 2 84 ? -14.375 -2.554 -18.144 1.00 26.45 ? 464 GLN B O 1 ATOM 3290 C CB . GLN B 2 84 ? -13.846 -1.021 -20.723 1.00 36.26 ? 464 GLN B CB 1 ATOM 3291 C CG . GLN B 2 84 ? -13.937 -0.224 -22.017 1.00 44.75 ? 464 GLN B CG 1 ATOM 3292 C CD . GLN B 2 84 ? -12.576 -0.169 -22.712 1.00 49.54 ? 464 GLN B CD 1 ATOM 3293 O OE1 . GLN B 2 84 ? -11.680 0.556 -22.275 1.00 54.48 ? 464 GLN B OE1 1 ATOM 3294 N NE2 . GLN B 2 84 ? -12.403 -0.965 -23.763 1.00 50.70 ? 464 GLN B NE2 1 ATOM 3295 N N . VAL B 2 85 ? -15.407 -3.748 -19.746 1.00 30.25 ? 465 VAL B N 1 ATOM 3296 C CA . VAL B 2 85 ? -15.259 -5.033 -19.075 1.00 31.12 ? 465 VAL B CA 1 ATOM 3297 C C . VAL B 2 85 ? -13.809 -5.322 -18.800 1.00 29.93 ? 465 VAL B C 1 ATOM 3298 O O . VAL B 2 85 ? -12.961 -5.126 -19.666 1.00 30.08 ? 465 VAL B O 1 ATOM 3299 C CB . VAL B 2 85 ? -15.822 -6.209 -19.913 1.00 30.24 ? 465 VAL B CB 1 ATOM 3300 C CG1 . VAL B 2 85 ? -15.450 -7.546 -19.291 1.00 30.48 ? 465 VAL B CG1 1 ATOM 3301 C CG2 . VAL B 2 85 ? -17.331 -6.090 -20.052 1.00 31.74 ? 465 VAL B CG2 1 ATOM 3302 N N . ARG B 2 86 ? -13.552 -5.832 -17.600 1.00 29.09 ? 466 ARG B N 1 ATOM 3303 C CA . ARG B 2 86 ? -12.213 -6.238 -17.181 1.00 30.05 ? 466 ARG B CA 1 ATOM 3304 C C . ARG B 2 86 ? -12.048 -7.752 -17.071 1.00 28.93 ? 466 ARG B C 1 ATOM 3305 O O . ARG B 2 86 ? -10.993 -8.271 -17.389 1.00 29.63 ? 466 ARG B O 1 ATOM 3306 C CB . ARG B 2 86 ? -11.877 -5.595 -15.841 1.00 32.51 ? 466 ARG B CB 1 ATOM 3307 C CG . ARG B 2 86 ? -11.450 -4.152 -16.017 1.00 38.58 ? 466 ARG B CG 1 ATOM 3308 C CD . ARG B 2 86 ? -11.128 -3.415 -14.722 1.00 41.22 ? 466 ARG B CD 1 ATOM 3309 N NE . ARG B 2 86 ? -10.047 -4.012 -13.937 1.00 45.11 ? 466 ARG B NE 1 ATOM 3310 C CZ . ARG B 2 86 ? -9.416 -3.397 -12.927 1.00 47.32 ? 466 ARG B CZ 1 ATOM 3311 N NH1 . ARG B 2 86 ? -9.741 -2.148 -12.576 1.00 46.00 ? 466 ARG B NH1 1 ATOM 3312 N NH2 . ARG B 2 86 ? -8.444 -4.035 -12.274 1.00 47.23 ? 466 ARG B NH2 1 ATOM 3313 N N . MET B 2 87 ? -13.064 -8.456 -16.576 1.00 27.51 ? 467 MET B N 1 ATOM 3314 C CA . MET B 2 87 ? -12.965 -9.890 -16.431 1.00 26.35 ? 467 MET B CA 1 ATOM 3315 C C . MET B 2 87 ? -14.336 -10.509 -16.540 1.00 25.79 ? 467 MET B C 1 ATOM 3316 O O . MET B 2 87 ? -15.319 -9.958 -16.050 1.00 25.59 ? 467 MET B O 1 ATOM 3317 C CB . MET B 2 87 ? -12.341 -10.228 -15.088 1.00 28.66 ? 467 MET B CB 1 ATOM 3318 C CG . MET B 2 87 ? -12.032 -11.703 -14.882 1.00 30.88 ? 467 MET B CG 1 ATOM 3319 S SD . MET B 2 87 ? -11.174 -11.854 -13.303 1.00 35.37 ? 467 MET B SD 1 ATOM 3320 C CE . MET B 2 87 ? -10.433 -13.471 -13.467 1.00 37.01 ? 467 MET B CE 1 ATOM 3321 N N . VAL B 2 88 ? -14.415 -11.643 -17.220 1.00 24.90 ? 468 VAL B N 1 ATOM 3322 C CA . VAL B 2 88 ? -15.641 -12.420 -17.233 1.00 24.18 ? 468 VAL B CA 1 ATOM 3323 C C . VAL B 2 88 ? -15.258 -13.801 -16.715 1.00 25.32 ? 468 VAL B C 1 ATOM 3324 O O . VAL B 2 88 ? -14.360 -14.439 -17.278 1.00 24.64 ? 468 VAL B O 1 ATOM 3325 C CB . VAL B 2 88 ? -16.227 -12.497 -18.633 1.00 24.80 ? 468 VAL B CB 1 ATOM 3326 C CG1 . VAL B 2 88 ? -17.604 -13.124 -18.581 1.00 26.92 ? 468 VAL B CG1 1 ATOM 3327 C CG2 . VAL B 2 88 ? -16.298 -11.101 -19.243 1.00 25.45 ? 468 VAL B CG2 1 ATOM 3328 N N . VAL B 2 89 ? -15.909 -14.251 -15.636 1.00 22.68 ? 469 VAL B N 1 ATOM 3329 C CA . VAL B 2 89 ? -15.440 -15.446 -14.935 1.00 23.31 ? 469 VAL B CA 1 ATOM 3330 C C . VAL B 2 89 ? -16.554 -16.149 -14.155 1.00 23.14 ? 469 VAL B C 1 ATOM 3331 O O . VAL B 2 89 ? -17.535 -15.535 -13.722 1.00 23.35 ? 469 VAL B O 1 ATOM 3332 C CB . VAL B 2 89 ? -14.281 -15.077 -13.993 1.00 23.26 ? 469 VAL B CB 1 ATOM 3333 C CG1 . VAL B 2 89 ? -14.756 -14.200 -12.852 1.00 23.08 ? 469 VAL B CG1 1 ATOM 3334 C CG2 . VAL B 2 89 ? -13.566 -16.299 -13.467 1.00 24.52 ? 469 VAL B CG2 1 ATOM 3335 N N . GLY B 2 90 ? -16.384 -17.450 -14.017 1.00 23.00 ? 470 GLY B N 1 ATOM 3336 C CA . GLY B 2 90 ? -17.249 -18.274 -13.205 1.00 24.05 ? 470 GLY B CA 1 ATOM 3337 C C . GLY B 2 90 ? -16.741 -19.695 -13.257 1.00 24.47 ? 470 GLY B C 1 ATOM 3338 O O . GLY B 2 90 ? -15.718 -19.979 -13.927 1.00 23.31 ? 470 GLY B O 1 ATOM 3339 N N . ALA B 2 91 ? -17.460 -20.587 -12.574 1.00 22.17 ? 471 ALA B N 1 ATOM 3340 C CA . ALA B 2 91 ? -17.014 -21.922 -12.457 1.00 22.43 ? 471 ALA B CA 1 ATOM 3341 C C . ALA B 2 91 ? -18.119 -22.929 -12.315 1.00 24.26 ? 471 ALA B C 1 ATOM 3342 O O . ALA B 2 91 ? -19.267 -22.600 -11.979 1.00 24.19 ? 471 ALA B O 1 ATOM 3343 C CB . ALA B 2 91 ? -16.078 -22.032 -11.274 1.00 23.34 ? 471 ALA B CB 1 ATOM 3344 N N . ALA B 2 92 ? -17.702 -24.170 -12.534 1.00 25.60 ? 472 ALA B N 1 ATOM 3345 C CA . ALA B 2 92 ? -18.471 -25.378 -12.294 1.00 27.93 ? 472 ALA B CA 1 ATOM 3346 C C . ALA B 2 92 ? -17.745 -26.191 -11.217 1.00 31.51 ? 472 ALA B C 1 ATOM 3347 O O . ALA B 2 92 ? -16.605 -25.863 -10.870 1.00 31.85 ? 472 ALA B O 1 ATOM 3348 C CB . ALA B 2 92 ? -18.555 -26.174 -13.569 1.00 27.68 ? 472 ALA B CB 1 ATOM 3349 N N . GLY B 2 93 ? -18.409 -27.210 -10.666 1.00 33.60 ? 473 GLY B N 1 ATOM 3350 C CA . GLY B 2 93 ? -17.809 -28.107 -9.669 1.00 34.21 ? 473 GLY B CA 1 ATOM 3351 C C . GLY B 2 93 ? -18.356 -28.066 -8.247 1.00 37.74 ? 473 GLY B C 1 ATOM 3352 O O . GLY B 2 93 ? -17.610 -28.168 -7.265 1.00 46.18 ? 473 GLY B O 1 ATOM 3353 N N . GLY B 2 94 ? -19.659 -27.904 -8.111 1.00 38.52 ? 474 GLY B N 1 ATOM 3354 C CA . GLY B 2 94 ? -20.297 -28.138 -6.845 1.00 37.15 ? 474 GLY B CA 1 ATOM 3355 C C . GLY B 2 94 ? -20.058 -27.014 -5.891 1.00 37.21 ? 474 GLY B C 1 ATOM 3356 O O . GLY B 2 94 ? -20.117 -25.831 -6.287 1.00 34.59 ? 474 GLY B O 1 ATOM 3357 N N . THR B 2 95 ? -19.793 -27.375 -4.631 1.00 33.75 ? 475 THR B N 1 ATOM 3358 C CA . THR B 2 95 ? -19.596 -26.365 -3.574 1.00 35.57 ? 475 THR B CA 1 ATOM 3359 C C . THR B 2 95 ? -18.284 -25.611 -3.739 1.00 30.41 ? 475 THR B C 1 ATOM 3360 O O . THR B 2 95 ? -18.099 -24.515 -3.168 1.00 35.96 ? 475 THR B O 1 ATOM 3361 C CB . THR B 2 95 ? -19.677 -26.971 -2.152 1.00 39.31 ? 475 THR B CB 1 ATOM 3362 O OG1 . THR B 2 95 ? -18.984 -28.237 -2.113 1.00 40.35 ? 475 THR B OG1 1 ATOM 3363 C CG2 . THR B 2 95 ? -21.154 -27.129 -1.725 1.00 40.01 ? 475 THR B CG2 1 ATOM 3364 N N . GLN B 2 96 ? -17.414 -26.139 -4.595 1.00 27.41 ? 476 GLN B N 1 ATOM 3365 C CA . GLN B 2 96 ? -16.147 -25.489 -4.877 1.00 27.80 ? 476 GLN B CA 1 ATOM 3366 C C . GLN B 2 96 ? -16.277 -24.373 -5.899 1.00 24.60 ? 476 GLN B C 1 ATOM 3367 O O . GLN B 2 96 ? -15.325 -23.669 -6.163 1.00 26.57 ? 476 GLN B O 1 ATOM 3368 C CB . GLN B 2 96 ? -15.137 -26.529 -5.334 1.00 30.45 ? 476 GLN B CB 1 ATOM 3369 C CG . GLN B 2 96 ? -14.995 -27.643 -4.312 1.00 33.74 ? 476 GLN B CG 1 ATOM 3370 C CD . GLN B 2 96 ? -14.710 -28.982 -4.945 1.00 38.74 ? 476 GLN B CD 1 ATOM 3371 O OE1 . GLN B 2 96 ? -15.218 -29.303 -6.019 1.00 45.00 ? 476 GLN B OE1 1 ATOM 3372 N NE2 . GLN B 2 96 ? -13.879 -29.765 -4.288 1.00 43.49 ? 476 GLN B NE2 1 ATOM 3373 N N . ILE B 2 97 ? -17.454 -24.196 -6.472 1.00 22.36 ? 477 ILE B N 1 ATOM 3374 C CA . ILE B 2 97 ? -17.634 -23.137 -7.461 1.00 22.80 ? 477 ILE B CA 1 ATOM 3375 C C . ILE B 2 97 ? -17.257 -21.756 -6.945 1.00 21.40 ? 477 ILE B C 1 ATOM 3376 O O . ILE B 2 97 ? -16.586 -21.013 -7.631 1.00 21.19 ? 477 ILE B O 1 ATOM 3377 C CB . ILE B 2 97 ? -19.072 -23.090 -7.989 1.00 22.59 ? 477 ILE B CB 1 ATOM 3378 C CG1 . ILE B 2 97 ? -19.333 -24.275 -8.916 1.00 23.81 ? 477 ILE B CG1 1 ATOM 3379 C CG2 . ILE B 2 97 ? -19.320 -21.790 -8.729 1.00 24.27 ? 477 ILE B CG2 1 ATOM 3380 C CD1 . ILE B 2 97 ? -20.819 -24.452 -9.231 1.00 25.32 ? 477 ILE B CD1 1 ATOM 3381 N N . THR B 2 98 ? -17.711 -21.416 -5.754 1.00 19.99 ? 478 THR B N 1 ATOM 3382 C CA . THR B 2 98 ? -17.566 -20.078 -5.234 1.00 22.54 ? 478 THR B CA 1 ATOM 3383 C C . THR B 2 98 ? -16.136 -19.777 -4.836 1.00 22.60 ? 478 THR B C 1 ATOM 3384 O O . THR B 2 98 ? -15.594 -18.703 -5.139 1.00 21.80 ? 478 THR B O 1 ATOM 3385 C CB . THR B 2 98 ? -18.481 -19.852 -4.007 1.00 22.73 ? 478 THR B CB 1 ATOM 3386 O OG1 . THR B 2 98 ? -19.747 -20.476 -4.257 1.00 22.96 ? 478 THR B OG1 1 ATOM 3387 C CG2 . THR B 2 98 ? -18.704 -18.379 -3.788 1.00 23.49 ? 478 THR B CG2 1 ATOM 3388 N N . THR B 2 99 ? -15.521 -20.742 -4.166 1.00 22.70 ? 479 THR B N 1 ATOM 3389 C CA . THR B 2 99 ? -14.134 -20.623 -3.796 1.00 22.98 ? 479 THR B CA 1 ATOM 3390 C C . THR B 2 99 ? -13.240 -20.568 -5.036 1.00 22.11 ? 479 THR B C 1 ATOM 3391 O O . THR B 2 99 ? -12.298 -19.799 -5.076 1.00 22.43 ? 479 THR B O 1 ATOM 3392 C CB . THR B 2 99 ? -13.727 -21.744 -2.819 1.00 22.67 ? 479 THR B CB 1 ATOM 3393 O OG1 . THR B 2 99 ? -14.050 -23.024 -3.368 1.00 24.52 ? 479 THR B OG1 1 ATOM 3394 C CG2 . THR B 2 99 ? -14.478 -21.581 -1.526 1.00 23.04 ? 479 THR B CG2 1 ATOM 3395 N N . ALA B 2 100 ? -13.526 -21.379 -6.044 1.00 21.55 ? 480 ALA B N 1 ATOM 3396 C CA . ALA B 2 100 ? -12.712 -21.389 -7.254 1.00 21.77 ? 480 ALA B CA 1 ATOM 3397 C C . ALA B 2 100 ? -12.852 -20.067 -8.000 1.00 23.12 ? 480 ALA B C 1 ATOM 3398 O O . ALA B 2 100 ? -11.871 -19.523 -8.523 1.00 22.43 ? 480 ALA B O 1 ATOM 3399 C CB . ALA B 2 100 ? -13.117 -22.549 -8.148 1.00 21.52 ? 480 ALA B CB 1 ATOM 3400 N N . THR B 2 101 ? -14.071 -19.532 -8.035 1.00 23.07 ? 481 THR B N 1 ATOM 3401 C CA . THR B 2 101 ? -14.298 -18.251 -8.697 1.00 22.33 ? 481 THR B CA 1 ATOM 3402 C C . THR B 2 101 ? -13.508 -17.140 -7.948 1.00 23.23 ? 481 THR B C 1 ATOM 3403 O O . THR B 2 101 ? -12.851 -16.300 -8.576 1.00 21.81 ? 481 THR B O 1 ATOM 3404 C CB . THR B 2 101 ? -15.778 -17.949 -8.796 1.00 22.62 ? 481 THR B CB 1 ATOM 3405 O OG1 . THR B 2 101 ? -16.402 -18.962 -9.614 1.00 23.60 ? 481 THR B OG1 1 ATOM 3406 C CG2 . THR B 2 101 ? -16.015 -16.585 -9.401 1.00 24.39 ? 481 THR B CG2 1 ATOM 3407 N N . ALA B 2 102 ? -13.542 -17.174 -6.622 1.00 21.64 ? 482 ALA B N 1 ATOM 3408 C CA . ALA B 2 102 ? -12.766 -16.252 -5.824 1.00 21.49 ? 482 ALA B CA 1 ATOM 3409 C C . ALA B 2 102 ? -11.288 -16.390 -6.145 1.00 22.90 ? 482 ALA B C 1 ATOM 3410 O O . ALA B 2 102 ? -10.596 -15.407 -6.366 1.00 23.04 ? 482 ALA B O 1 ATOM 3411 C CB . ALA B 2 102 ? -13.016 -16.499 -4.369 1.00 21.10 ? 482 ALA B CB 1 ATOM 3412 N N . LEU B 2 103 ? -10.798 -17.617 -6.190 1.00 24.10 ? 483 LEU B N 1 ATOM 3413 C CA . LEU B 2 103 ? -9.369 -17.824 -6.457 1.00 24.84 ? 483 LEU B CA 1 ATOM 3414 C C . LEU B 2 103 ? -8.985 -17.278 -7.828 1.00 24.32 ? 483 LEU B C 1 ATOM 3415 O O . LEU B 2 103 ? -8.007 -16.519 -7.950 1.00 23.88 ? 483 LEU B O 1 ATOM 3416 C CB . LEU B 2 103 ? -8.966 -19.302 -6.307 1.00 23.81 ? 483 LEU B CB 1 ATOM 3417 C CG . LEU B 2 103 ? -8.958 -19.812 -4.872 1.00 23.56 ? 483 LEU B CG 1 ATOM 3418 C CD1 . LEU B 2 103 ? -8.812 -21.328 -4.829 1.00 23.23 ? 483 LEU B CD1 1 ATOM 3419 C CD2 . LEU B 2 103 ? -7.894 -19.137 -3.994 1.00 23.05 ? 483 LEU B CD2 1 ATOM 3420 N N . ALA B 2 104 ? -9.752 -17.605 -8.862 1.00 24.38 ? 484 ALA B N 1 ATOM 3421 C CA . ALA B 2 104 ? -9.421 -17.039 -10.186 1.00 25.74 ? 484 ALA B CA 1 ATOM 3422 C C . ALA B 2 104 ? -9.340 -15.498 -10.194 1.00 24.87 ? 484 ALA B C 1 ATOM 3423 O O . ALA B 2 104 ? -8.468 -14.917 -10.850 1.00 22.99 ? 484 ALA B O 1 ATOM 3424 C CB . ALA B 2 104 ? -10.368 -17.535 -11.270 1.00 26.95 ? 484 ALA B CB 1 ATOM 3425 N N . ILE B 2 105 ? -10.244 -14.843 -9.481 1.00 24.13 ? 485 ILE B N 1 ATOM 3426 C CA . ILE B 2 105 ? -10.210 -13.405 -9.372 1.00 24.98 ? 485 ILE B CA 1 ATOM 3427 C C . ILE B 2 105 ? -8.973 -12.944 -8.581 1.00 24.63 ? 485 ILE B C 1 ATOM 3428 O O . ILE B 2 105 ? -8.244 -12.077 -9.033 1.00 25.26 ? 485 ILE B O 1 ATOM 3429 C CB . ILE B 2 105 ? -11.499 -12.870 -8.732 1.00 25.80 ? 485 ILE B CB 1 ATOM 3430 C CG1 . ILE B 2 105 ? -12.663 -13.041 -9.704 1.00 25.01 ? 485 ILE B CG1 1 ATOM 3431 C CG2 . ILE B 2 105 ? -11.367 -11.398 -8.382 1.00 27.15 ? 485 ILE B CG2 1 ATOM 3432 C CD1 . ILE B 2 105 ? -14.012 -12.949 -9.059 1.00 24.87 ? 485 ILE B CD1 1 ATOM 3433 N N . ILE B 2 106 ? -8.727 -13.531 -7.424 1.00 23.90 ? 486 ILE B N 1 ATOM 3434 C CA . ILE B 2 106 ? -7.554 -13.187 -6.611 1.00 24.70 ? 486 ILE B CA 1 ATOM 3435 C C . ILE B 2 106 ? -6.266 -13.329 -7.426 1.00 27.88 ? 486 ILE B C 1 ATOM 3436 O O . ILE B 2 106 ? -5.411 -12.441 -7.410 1.00 26.72 ? 486 ILE B O 1 ATOM 3437 C CB . ILE B 2 106 ? -7.461 -14.106 -5.380 1.00 26.33 ? 486 ILE B CB 1 ATOM 3438 C CG1 . ILE B 2 106 ? -8.491 -13.709 -4.322 1.00 25.53 ? 486 ILE B CG1 1 ATOM 3439 C CG2 . ILE B 2 106 ? -6.049 -14.137 -4.791 1.00 26.27 ? 486 ILE B CG2 1 ATOM 3440 C CD1 . ILE B 2 106 ? -8.952 -14.893 -3.484 1.00 26.37 ? 486 ILE B CD1 1 ATOM 3441 N N . TYR B 2 107 ? -6.154 -14.458 -8.139 1.00 26.59 ? 487 TYR B N 1 ATOM 3442 C CA . TYR B 2 107 ? -4.966 -14.790 -8.877 1.00 25.73 ? 487 TYR B CA 1 ATOM 3443 C C . TYR B 2 107 ? -4.656 -13.750 -9.950 1.00 27.28 ? 487 TYR B C 1 ATOM 3444 O O . TYR B 2 107 ? -3.511 -13.333 -10.085 1.00 28.03 ? 487 TYR B O 1 ATOM 3445 C CB . TYR B 2 107 ? -5.081 -16.180 -9.502 1.00 24.01 ? 487 TYR B CB 1 ATOM 3446 C CG . TYR B 2 107 ? -5.085 -17.367 -8.534 1.00 24.20 ? 487 TYR B CG 1 ATOM 3447 C CD1 . TYR B 2 107 ? -4.704 -17.235 -7.214 1.00 22.58 ? 487 TYR B CD1 1 ATOM 3448 C CD2 . TYR B 2 107 ? -5.447 -18.648 -8.983 1.00 24.21 ? 487 TYR B CD2 1 ATOM 3449 C CE1 . TYR B 2 107 ? -4.702 -18.322 -6.353 1.00 23.99 ? 487 TYR B CE1 1 ATOM 3450 C CE2 . TYR B 2 107 ? -5.418 -19.757 -8.132 1.00 24.48 ? 487 TYR B CE2 1 ATOM 3451 C CZ . TYR B 2 107 ? -5.049 -19.594 -6.809 1.00 24.68 ? 487 TYR B CZ 1 ATOM 3452 O OH . TYR B 2 107 ? -5.015 -20.702 -5.940 1.00 23.33 ? 487 TYR B OH 1 ATOM 3453 N N . ASN B 2 108 ? -5.656 -13.338 -10.707 1.00 28.00 ? 488 ASN B N 1 ATOM 3454 C CA . ASN B 2 108 ? -5.457 -12.336 -11.741 1.00 28.37 ? 488 ASN B CA 1 ATOM 3455 C C . ASN B 2 108 ? -5.378 -10.911 -11.202 1.00 29.35 ? 488 ASN B C 1 ATOM 3456 O O . ASN B 2 108 ? -4.456 -10.173 -11.500 1.00 30.53 ? 488 ASN B O 1 ATOM 3457 C CB . ASN B 2 108 ? -6.579 -12.412 -12.771 1.00 27.14 ? 488 ASN B CB 1 ATOM 3458 C CG . ASN B 2 108 ? -6.377 -11.424 -13.911 1.00 27.84 ? 488 ASN B CG 1 ATOM 3459 O OD1 . ASN B 2 108 ? -7.065 -10.421 -13.995 1.00 28.92 ? 488 ASN B OD1 1 ATOM 3460 N ND2 . ASN B 2 108 ? -5.421 -11.700 -14.775 1.00 29.13 ? 488 ASN B ND2 1 ATOM 3461 N N . LEU B 2 109 ? -6.372 -10.528 -10.419 1.00 28.46 ? 489 LEU B N 1 ATOM 3462 C CA . LEU B 2 109 ? -6.511 -9.162 -9.972 1.00 29.47 ? 489 LEU B CA 1 ATOM 3463 C C . LEU B 2 109 ? -5.397 -8.730 -9.014 1.00 29.31 ? 489 LEU B C 1 ATOM 3464 O O . LEU B 2 109 ? -4.828 -7.675 -9.189 1.00 30.00 ? 489 LEU B O 1 ATOM 3465 C CB . LEU B 2 109 ? -7.872 -8.967 -9.323 1.00 29.73 ? 489 LEU B CB 1 ATOM 3466 C CG . LEU B 2 109 ? -8.198 -7.559 -8.885 1.00 32.98 ? 489 LEU B CG 1 ATOM 3467 C CD1 . LEU B 2 109 ? -8.248 -6.591 -10.071 1.00 33.52 ? 489 LEU B CD1 1 ATOM 3468 C CD2 . LEU B 2 109 ? -9.513 -7.580 -8.118 1.00 34.11 ? 489 LEU B CD2 1 ATOM 3469 N N . TRP B 2 110 ? -5.077 -9.565 -8.036 1.00 29.98 ? 490 TRP B N 1 ATOM 3470 C CA . TRP B 2 110 ? -4.125 -9.229 -6.987 1.00 28.91 ? 490 TRP B CA 1 ATOM 3471 C C . TRP B 2 110 ? -2.761 -9.880 -7.133 1.00 29.42 ? 490 TRP B C 1 ATOM 3472 O O . TRP B 2 110 ? -1.767 -9.239 -6.846 1.00 31.57 ? 490 TRP B O 1 ATOM 3473 C CB . TRP B 2 110 ? -4.721 -9.553 -5.605 1.00 28.39 ? 490 TRP B CB 1 ATOM 3474 C CG . TRP B 2 110 ? -5.870 -8.692 -5.268 1.00 26.42 ? 490 TRP B CG 1 ATOM 3475 C CD1 . TRP B 2 110 ? -6.083 -7.417 -5.702 1.00 27.07 ? 490 TRP B CD1 1 ATOM 3476 C CD2 . TRP B 2 110 ? -6.966 -9.013 -4.404 1.00 27.77 ? 490 TRP B CD2 1 ATOM 3477 N NE1 . TRP B 2 110 ? -7.252 -6.920 -5.166 1.00 27.36 ? 490 TRP B NE1 1 ATOM 3478 C CE2 . TRP B 2 110 ? -7.815 -7.877 -4.369 1.00 26.84 ? 490 TRP B CE2 1 ATOM 3479 C CE3 . TRP B 2 110 ? -7.315 -10.148 -3.646 1.00 27.35 ? 490 TRP B CE3 1 ATOM 3480 C CZ2 . TRP B 2 110 ? -8.994 -7.846 -3.633 1.00 27.17 ? 490 TRP B CZ2 1 ATOM 3481 C CZ3 . TRP B 2 110 ? -8.479 -10.110 -2.900 1.00 26.51 ? 490 TRP B CZ3 1 ATOM 3482 C CH2 . TRP B 2 110 ? -9.312 -8.962 -2.901 1.00 27.52 ? 490 TRP B CH2 1 ATOM 3483 N N . PHE B 2 111 ? -2.681 -11.139 -7.554 1.00 29.45 ? 491 PHE B N 1 ATOM 3484 C CA . PHE B 2 111 ? -1.375 -11.787 -7.661 1.00 27.93 ? 491 PHE B CA 1 ATOM 3485 C C . PHE B 2 111 ? -0.700 -11.481 -9.003 1.00 29.82 ? 491 PHE B C 1 ATOM 3486 O O . PHE B 2 111 ? 0.476 -11.715 -9.153 1.00 32.35 ? 491 PHE B O 1 ATOM 3487 C CB . PHE B 2 111 ? -1.435 -13.305 -7.502 1.00 26.89 ? 491 PHE B CB 1 ATOM 3488 C CG . PHE B 2 111 ? -1.887 -13.803 -6.144 1.00 26.30 ? 491 PHE B CG 1 ATOM 3489 C CD1 . PHE B 2 111 ? -1.995 -12.967 -5.032 1.00 26.72 ? 491 PHE B CD1 1 ATOM 3490 C CD2 . PHE B 2 111 ? -2.179 -15.157 -5.990 1.00 24.61 ? 491 PHE B CD2 1 ATOM 3491 C CE1 . PHE B 2 111 ? -2.440 -13.471 -3.813 1.00 26.60 ? 491 PHE B CE1 1 ATOM 3492 C CE2 . PHE B 2 111 ? -2.599 -15.664 -4.778 1.00 25.64 ? 491 PHE B CE2 1 ATOM 3493 C CZ . PHE B 2 111 ? -2.741 -14.819 -3.680 1.00 25.25 ? 491 PHE B CZ 1 ATOM 3494 N N . GLY B 2 112 ? -1.450 -10.996 -9.980 1.00 30.98 ? 492 GLY B N 1 ATOM 3495 C CA . GLY B 2 112 ? -0.889 -10.571 -11.254 1.00 32.04 ? 492 GLY B CA 1 ATOM 3496 C C . GLY B 2 112 ? -0.705 -11.708 -12.243 1.00 33.98 ? 492 GLY B C 1 ATOM 3497 O O . GLY B 2 112 ? -0.028 -11.529 -13.228 1.00 34.48 ? 492 GLY B O 1 ATOM 3498 N N . TYR B 2 113 ? -1.331 -12.864 -12.006 1.00 31.03 ? 493 TYR B N 1 ATOM 3499 C CA . TYR B 2 113 ? -1.249 -13.978 -12.934 1.00 31.27 ? 493 TYR B CA 1 ATOM 3500 C C . TYR B 2 113 ? -2.089 -13.711 -14.195 1.00 33.57 ? 493 TYR B C 1 ATOM 3501 O O . TYR B 2 113 ? -3.235 -13.249 -14.100 1.00 32.78 ? 493 TYR B O 1 ATOM 3502 C CB . TYR B 2 113 ? -1.719 -15.285 -12.265 1.00 31.45 ? 493 TYR B CB 1 ATOM 3503 C CG . TYR B 2 113 ? -0.960 -15.723 -11.033 1.00 30.20 ? 493 TYR B CG 1 ATOM 3504 C CD1 . TYR B 2 113 ? 0.278 -15.146 -10.662 1.00 31.33 ? 493 TYR B CD1 1 ATOM 3505 C CD2 . TYR B 2 113 ? -1.479 -16.715 -10.216 1.00 30.31 ? 493 TYR B CD2 1 ATOM 3506 C CE1 . TYR B 2 113 ? 0.949 -15.571 -9.513 1.00 30.34 ? 493 TYR B CE1 1 ATOM 3507 C CE2 . TYR B 2 113 ? -0.806 -17.150 -9.077 1.00 29.42 ? 493 TYR B CE2 1 ATOM 3508 C CZ . TYR B 2 113 ? 0.388 -16.576 -8.725 1.00 29.15 ? 493 TYR B CZ 1 ATOM 3509 O OH . TYR B 2 113 ? 1.012 -17.037 -7.597 1.00 28.80 ? 493 TYR B OH 1 ATOM 3510 N N . ASP B 2 114 ? -1.522 -13.971 -15.377 1.00 33.27 ? 494 ASP B N 1 ATOM 3511 C CA . ASP B 2 114 ? -2.299 -13.842 -16.593 1.00 35.23 ? 494 ASP B CA 1 ATOM 3512 C C . ASP B 2 114 ? -3.440 -14.872 -16.580 1.00 32.86 ? 494 ASP B C 1 ATOM 3513 O O . ASP B 2 114 ? -3.417 -15.859 -15.809 1.00 31.44 ? 494 ASP B O 1 ATOM 3514 C CB . ASP B 2 114 ? -1.440 -13.950 -17.867 1.00 41.06 ? 494 ASP B CB 1 ATOM 3515 C CG . ASP B 2 114 ? -0.748 -15.301 -18.035 1.00 45.84 ? 494 ASP B CG 1 ATOM 3516 O OD1 . ASP B 2 114 ? -1.383 -16.374 -17.967 1.00 51.85 ? 494 ASP B OD1 1 ATOM 3517 O OD2 . ASP B 2 114 ? 0.464 -15.284 -18.309 1.00 57.26 ? 494 ASP B OD2 1 ATOM 3518 N N . VAL B 2 115 ? -4.433 -14.630 -17.415 1.00 28.32 ? 495 VAL B N 1 ATOM 3519 C CA . VAL B 2 115 ? -5.669 -15.356 -17.312 1.00 30.62 ? 495 VAL B CA 1 ATOM 3520 C C . VAL B 2 115 ? -5.511 -16.862 -17.423 1.00 29.35 ? 495 VAL B C 1 ATOM 3521 O O . VAL B 2 115 ? -6.155 -17.593 -16.675 1.00 29.62 ? 495 VAL B O 1 ATOM 3522 C CB . VAL B 2 115 ? -6.738 -14.887 -18.312 1.00 30.77 ? 495 VAL B CB 1 ATOM 3523 C CG1 . VAL B 2 115 ? -6.352 -15.244 -19.740 1.00 31.80 ? 495 VAL B CG1 1 ATOM 3524 C CG2 . VAL B 2 115 ? -8.073 -15.527 -17.941 1.00 31.49 ? 495 VAL B CG2 1 ATOM 3525 N N . LYS B 2 116 ? -4.655 -17.333 -18.321 1.00 28.23 ? 496 LYS B N 1 ATOM 3526 C CA . LYS B 2 116 ? -4.445 -18.759 -18.433 1.00 30.17 ? 496 LYS B CA 1 ATOM 3527 C C . LYS B 2 116 ? -3.868 -19.311 -17.145 1.00 31.18 ? 496 LYS B C 1 ATOM 3528 O O . LYS B 2 116 ? -4.308 -20.371 -16.661 1.00 27.25 ? 496 LYS B O 1 ATOM 3529 C CB . LYS B 2 116 ? -3.533 -19.118 -19.599 1.00 31.52 ? 496 LYS B CB 1 ATOM 3530 C CG . LYS B 2 116 ? -3.343 -20.617 -19.797 1.00 32.25 ? 496 LYS B CG 1 ATOM 3531 C CD . LYS B 2 116 ? -4.662 -21.387 -19.882 1.00 33.51 ? 496 LYS B CD 1 ATOM 3532 C CE . LYS B 2 116 ? -4.480 -22.798 -20.482 1.00 33.50 ? 496 LYS B CE 1 ATOM 3533 N NZ . LYS B 2 116 ? -5.751 -23.589 -20.547 1.00 32.12 ? 496 LYS B NZ 1 ATOM 3534 N N . ARG B 2 117 ? -2.866 -18.617 -16.602 1.00 31.70 ? 497 ARG B N 1 ATOM 3535 C CA . ARG B 2 117 ? -2.284 -19.044 -15.332 1.00 33.12 ? 497 ARG B CA 1 ATOM 3536 C C . ARG B 2 117 ? -3.313 -18.977 -14.195 1.00 30.47 ? 497 ARG B C 1 ATOM 3537 O O . ARG B 2 117 ? -3.357 -19.838 -13.328 1.00 33.48 ? 497 ARG B O 1 ATOM 3538 C CB . ARG B 2 117 ? -1.053 -18.211 -14.943 1.00 35.09 ? 497 ARG B CB 1 ATOM 3539 C CG . ARG B 2 117 ? -0.475 -18.734 -13.641 1.00 35.13 ? 497 ARG B CG 1 ATOM 3540 C CD . ARG B 2 117 ? 0.864 -18.177 -13.243 1.00 37.11 ? 497 ARG B CD 1 ATOM 3541 N NE . ARG B 2 117 ? 1.251 -18.827 -11.989 1.00 41.10 ? 497 ARG B NE 1 ATOM 3542 C CZ . ARG B 2 117 ? 2.328 -18.528 -11.266 1.00 44.66 ? 497 ARG B CZ 1 ATOM 3543 N NH1 . ARG B 2 117 ? 3.157 -17.568 -11.666 1.00 46.59 ? 497 ARG B NH1 1 ATOM 3544 N NH2 . ARG B 2 117 ? 2.563 -19.191 -10.130 1.00 43.63 ? 497 ARG B NH2 1 ATOM 3545 N N . ALA B 2 118 ? -4.136 -17.955 -14.201 1.00 28.96 ? 498 ALA B N 1 ATOM 3546 C CA . ALA B 2 118 ? -5.176 -17.826 -13.191 1.00 29.59 ? 498 ALA B CA 1 ATOM 3547 C C . ALA B 2 118 ? -6.144 -19.018 -13.199 1.00 29.25 ? 498 ALA B C 1 ATOM 3548 O O . ALA B 2 118 ? -6.662 -19.397 -12.169 1.00 29.23 ? 498 ALA B O 1 ATOM 3549 C CB . ALA B 2 118 ? -5.950 -16.535 -13.396 1.00 29.63 ? 498 ALA B CB 1 ATOM 3550 N N . VAL B 2 119 ? -6.377 -19.583 -14.378 1.00 29.51 ? 499 VAL B N 1 ATOM 3551 C CA . VAL B 2 119 ? -7.245 -20.735 -14.553 1.00 29.12 ? 499 VAL B CA 1 ATOM 3552 C C . VAL B 2 119 ? -6.523 -22.026 -14.212 1.00 28.78 ? 499 VAL B C 1 ATOM 3553 O O . VAL B 2 119 ? -7.125 -22.929 -13.639 1.00 31.19 ? 499 VAL B O 1 ATOM 3554 C CB . VAL B 2 119 ? -7.791 -20.776 -15.995 1.00 28.33 ? 499 VAL B CB 1 ATOM 3555 C CG1 . VAL B 2 119 ? -8.379 -22.129 -16.340 1.00 29.36 ? 499 VAL B CG1 1 ATOM 3556 C CG2 . VAL B 2 119 ? -8.821 -19.677 -16.157 1.00 28.90 ? 499 VAL B CG2 1 ATOM 3557 N N . GLU B 2 120 ? -5.241 -22.122 -14.548 1.00 27.58 ? 500 GLU B N 1 ATOM 3558 C CA . GLU B 2 120 ? -4.520 -23.389 -14.390 1.00 27.94 ? 500 GLU B CA 1 ATOM 3559 C C . GLU B 2 120 ? -3.920 -23.517 -13.015 1.00 26.92 ? 500 GLU B C 1 ATOM 3560 O O . GLU B 2 120 ? -3.624 -24.608 -12.594 1.00 29.47 ? 500 GLU B O 1 ATOM 3561 C CB . GLU B 2 120 ? -3.422 -23.555 -15.464 1.00 28.96 ? 500 GLU B CB 1 ATOM 3562 C CG . GLU B 2 120 ? -3.977 -23.671 -16.883 1.00 30.38 ? 500 GLU B CG 1 ATOM 3563 C CD . GLU B 2 120 ? -4.931 -24.836 -17.053 1.00 30.55 ? 500 GLU B CD 1 ATOM 3564 O OE1 . GLU B 2 120 ? -4.689 -25.898 -16.451 1.00 32.79 ? 500 GLU B OE1 1 ATOM 3565 O OE2 . GLU B 2 120 ? -5.914 -24.708 -17.804 1.00 32.58 ? 500 GLU B OE2 1 ATOM 3566 N N . GLU B 2 121 ? -3.762 -22.401 -12.306 1.00 27.33 ? 501 GLU B N 1 ATOM 3567 C CA . GLU B 2 121 ? -3.124 -22.406 -11.006 1.00 26.95 ? 501 GLU B CA 1 ATOM 3568 C C . GLU B 2 121 ? -3.855 -23.360 -10.066 1.00 28.70 ? 501 GLU B C 1 ATOM 3569 O O . GLU B 2 121 ? -5.088 -23.374 -10.027 1.00 30.80 ? 501 GLU B O 1 ATOM 3570 C CB . GLU B 2 121 ? -3.101 -20.999 -10.422 1.00 27.41 ? 501 GLU B CB 1 ATOM 3571 C CG . GLU B 2 121 ? -2.413 -20.846 -9.074 1.00 28.82 ? 501 GLU B CG 1 ATOM 3572 C CD . GLU B 2 121 ? -0.886 -20.938 -9.127 1.00 30.61 ? 501 GLU B CD 1 ATOM 3573 O OE1 . GLU B 2 121 ? -0.279 -20.827 -10.224 1.00 30.36 ? 501 GLU B OE1 1 ATOM 3574 O OE2 . GLU B 2 121 ? -0.294 -21.131 -8.036 1.00 33.85 ? 501 GLU B OE2 1 ATOM 3575 N N . PRO B 2 122 ? -3.098 -24.182 -9.320 1.00 28.06 ? 502 PRO B N 1 ATOM 3576 C CA . PRO B 2 122 ? -3.700 -25.029 -8.304 1.00 27.00 ? 502 PRO B CA 1 ATOM 3577 C C . PRO B 2 122 ? -4.649 -24.284 -7.327 1.00 26.02 ? 502 PRO B C 1 ATOM 3578 O O . PRO B 2 122 ? -4.399 -23.143 -6.942 1.00 24.57 ? 502 PRO B O 1 ATOM 3579 C CB . PRO B 2 122 ? -2.485 -25.538 -7.524 1.00 28.74 ? 502 PRO B CB 1 ATOM 3580 C CG . PRO B 2 122 ? -1.337 -25.468 -8.493 1.00 29.89 ? 502 PRO B CG 1 ATOM 3581 C CD . PRO B 2 122 ? -1.621 -24.276 -9.336 1.00 28.11 ? 502 PRO B CD 1 ATOM 3582 N N . ARG B 2 123 ? -5.680 -24.983 -6.894 1.00 25.16 ? 503 ARG B N 1 ATOM 3583 C CA . ARG B 2 123 ? -6.714 -24.430 -6.038 1.00 26.79 ? 503 ARG B CA 1 ATOM 3584 C C . ARG B 2 123 ? -6.800 -25.239 -4.740 1.00 25.00 ? 503 ARG B C 1 ATOM 3585 O O . ARG B 2 123 ? -6.212 -26.310 -4.617 1.00 25.29 ? 503 ARG B O 1 ATOM 3586 C CB . ARG B 2 123 ? -8.053 -24.424 -6.788 1.00 25.70 ? 503 ARG B CB 1 ATOM 3587 C CG . ARG B 2 123 ? -7.975 -23.508 -8.001 1.00 28.18 ? 503 ARG B CG 1 ATOM 3588 C CD . ARG B 2 123 ? -9.306 -23.138 -8.641 1.00 27.03 ? 503 ARG B CD 1 ATOM 3589 N NE . ARG B 2 123 ? -9.811 -24.187 -9.487 1.00 25.95 ? 503 ARG B NE 1 ATOM 3590 C CZ . ARG B 2 123 ? -9.781 -24.228 -10.813 1.00 26.49 ? 503 ARG B CZ 1 ATOM 3591 N NH1 . ARG B 2 123 ? -9.248 -23.271 -11.553 1.00 27.23 ? 503 ARG B NH1 1 ATOM 3592 N NH2 . ARG B 2 123 ? -10.312 -25.268 -11.410 1.00 26.39 ? 503 ARG B NH2 1 ATOM 3593 N N . LEU B 2 124 ? -7.525 -24.690 -3.782 1.00 23.93 ? 504 LEU B N 1 ATOM 3594 C CA . LEU B 2 124 ? -7.835 -25.341 -2.536 1.00 22.79 ? 504 LEU B CA 1 ATOM 3595 C C . LEU B 2 124 ? -9.217 -24.879 -2.114 1.00 23.70 ? 504 LEU B C 1 ATOM 3596 O O . LEU B 2 124 ? -9.776 -23.912 -2.690 1.00 22.98 ? 504 LEU B O 1 ATOM 3597 C CB . LEU B 2 124 ? -6.799 -24.996 -1.478 1.00 24.52 ? 504 LEU B CB 1 ATOM 3598 C CG . LEU B 2 124 ? -6.786 -23.622 -0.814 1.00 24.16 ? 504 LEU B CG 1 ATOM 3599 C CD1 . LEU B 2 124 ? -5.574 -23.555 0.112 1.00 25.81 ? 504 LEU B CD1 1 ATOM 3600 C CD2 . LEU B 2 124 ? -6.743 -22.475 -1.806 1.00 24.56 ? 504 LEU B CD2 1 ATOM 3601 N N . HIS B 2 125 ? -9.770 -25.542 -1.104 1.00 22.00 ? 505 HIS B N 1 ATOM 3602 C CA . HIS B 2 125 ? -11.157 -25.310 -0.737 1.00 22.89 ? 505 HIS B CA 1 ATOM 3603 C C . HIS B 2 125 ? -11.395 -25.667 0.693 1.00 23.01 ? 505 HIS B C 1 ATOM 3604 O O . HIS B 2 125 ? -10.867 -26.678 1.196 1.00 23.32 ? 505 HIS B O 1 ATOM 3605 C CB . HIS B 2 125 ? -12.054 -26.175 -1.627 1.00 24.21 ? 505 HIS B CB 1 ATOM 3606 C CG . HIS B 2 125 ? -13.502 -26.134 -1.266 1.00 24.40 ? 505 HIS B CG 1 ATOM 3607 N ND1 . HIS B 2 125 ? -14.311 -25.051 -1.554 1.00 24.61 ? 505 HIS B ND1 1 ATOM 3608 C CD2 . HIS B 2 125 ? -14.297 -27.059 -0.681 1.00 23.71 ? 505 HIS B CD2 1 ATOM 3609 C CE1 . HIS B 2 125 ? -15.541 -25.311 -1.153 1.00 24.98 ? 505 HIS B CE1 1 ATOM 3610 N NE2 . HIS B 2 125 ? -15.560 -26.525 -0.627 1.00 25.44 ? 505 HIS B NE2 1 ATOM 3611 N N . ASN B 2 126 ? -12.146 -24.811 1.367 1.00 23.66 ? 506 ASN B N 1 ATOM 3612 C CA . ASN B 2 126 ? -12.682 -25.122 2.680 1.00 25.04 ? 506 ASN B CA 1 ATOM 3613 C C . ASN B 2 126 ? -14.039 -24.488 2.763 1.00 26.58 ? 506 ASN B C 1 ATOM 3614 O O . ASN B 2 126 ? -14.184 -23.326 2.418 1.00 27.57 ? 506 ASN B O 1 ATOM 3615 C CB . ASN B 2 126 ? -11.792 -24.538 3.763 1.00 25.16 ? 506 ASN B CB 1 ATOM 3616 C CG . ASN B 2 126 ? -12.078 -25.137 5.113 1.00 26.33 ? 506 ASN B CG 1 ATOM 3617 O OD1 . ASN B 2 126 ? -13.202 -25.049 5.639 1.00 24.68 ? 506 ASN B OD1 1 ATOM 3618 N ND2 . ASN B 2 126 ? -11.061 -25.762 5.694 1.00 26.93 ? 506 ASN B ND2 1 ATOM 3619 N N . GLN B 2 127 ? -15.035 -25.224 3.225 1.00 27.64 ? 507 GLN B N 1 ATOM 3620 C CA . GLN B 2 127 ? -16.395 -24.668 3.295 1.00 28.78 ? 507 GLN B CA 1 ATOM 3621 C C . GLN B 2 127 ? -16.949 -24.746 4.703 1.00 27.11 ? 507 GLN B C 1 ATOM 3622 O O . GLN B 2 127 ? -18.154 -24.709 4.911 1.00 28.20 ? 507 GLN B O 1 ATOM 3623 C CB . GLN B 2 127 ? -17.317 -25.402 2.320 1.00 29.03 ? 507 GLN B CB 1 ATOM 3624 C CG . GLN B 2 127 ? -17.477 -26.884 2.620 1.00 29.51 ? 507 GLN B CG 1 ATOM 3625 C CD . GLN B 2 127 ? -18.300 -27.617 1.569 1.00 30.53 ? 507 GLN B CD 1 ATOM 3626 O OE1 . GLN B 2 127 ? -17.968 -27.619 0.377 1.00 27.09 ? 507 GLN B OE1 1 ATOM 3627 N NE2 . GLN B 2 127 ? -19.368 -28.250 2.010 1.00 30.26 ? 507 GLN B NE2 1 ATOM 3628 N N . LEU B 2 128 ? -16.047 -24.856 5.661 1.00 27.43 ? 508 LEU B N 1 ATOM 3629 C CA . LEU B 2 128 ? -16.348 -24.832 7.087 1.00 29.05 ? 508 LEU B CA 1 ATOM 3630 C C . LEU B 2 128 ? -16.914 -26.151 7.565 1.00 30.90 ? 508 LEU B C 1 ATOM 3631 O O . LEU B 2 128 ? -16.365 -26.760 8.467 1.00 28.66 ? 508 LEU B O 1 ATOM 3632 C CB . LEU B 2 128 ? -17.264 -23.669 7.485 1.00 29.15 ? 508 LEU B CB 1 ATOM 3633 C CG . LEU B 2 128 ? -17.535 -23.555 8.997 1.00 30.51 ? 508 LEU B CG 1 ATOM 3634 C CD1 . LEU B 2 128 ? -16.274 -23.268 9.785 1.00 28.72 ? 508 LEU B CD1 1 ATOM 3635 C CD2 . LEU B 2 128 ? -18.561 -22.479 9.279 1.00 31.18 ? 508 LEU B CD2 1 ATOM 3636 N N . LEU B 2 129 ? -18.006 -26.587 6.958 1.00 34.28 ? 509 LEU B N 1 ATOM 3637 C CA . LEU B 2 129 ? -18.591 -27.881 7.251 1.00 37.79 ? 509 LEU B CA 1 ATOM 3638 C C . LEU B 2 129 ? -18.730 -28.647 5.942 1.00 36.33 ? 509 LEU B C 1 ATOM 3639 O O . LEU B 2 129 ? -19.500 -28.212 5.086 1.00 37.36 ? 509 LEU B O 1 ATOM 3640 C CB . LEU B 2 129 ? -19.999 -27.674 7.846 1.00 41.90 ? 509 LEU B CB 1 ATOM 3641 C CG . LEU B 2 129 ? -20.144 -26.829 9.116 1.00 42.03 ? 509 LEU B CG 1 ATOM 3642 C CD1 . LEU B 2 129 ? -21.353 -25.902 9.032 1.00 45.56 ? 509 LEU B CD1 1 ATOM 3643 C CD2 . LEU B 2 129 ? -20.239 -27.736 10.324 1.00 43.74 ? 509 LEU B CD2 1 ATOM 3644 N N . PRO B 2 130 ? -18.042 -29.769 5.751 1.00 39.75 ? 510 PRO B N 1 ATOM 3645 C CA . PRO B 2 130 ? -17.135 -30.353 6.726 1.00 42.66 ? 510 PRO B CA 1 ATOM 3646 C C . PRO B 2 130 ? -15.880 -29.538 6.939 1.00 42.51 ? 510 PRO B C 1 ATOM 3647 O O . PRO B 2 130 ? -15.567 -28.621 6.172 1.00 43.81 ? 510 PRO B O 1 ATOM 3648 C CB . PRO B 2 130 ? -16.785 -31.731 6.124 1.00 44.65 ? 510 PRO B CB 1 ATOM 3649 C CG . PRO B 2 130 ? -17.129 -31.634 4.673 1.00 44.07 ? 510 PRO B CG 1 ATOM 3650 C CD . PRO B 2 130 ? -18.236 -30.635 4.572 1.00 41.89 ? 510 PRO B CD 1 ATOM 3651 N N . ASN B 2 131 ? -15.170 -29.927 7.981 1.00 41.48 ? 511 ASN B N 1 ATOM 3652 C CA . ASN B 2 131 ? -14.104 -29.165 8.584 1.00 41.76 ? 511 ASN B CA 1 ATOM 3653 C C . ASN B 2 131 ? -12.741 -29.675 8.153 1.00 43.82 ? 511 ASN B C 1 ATOM 3654 O O . ASN B 2 131 ? -11.977 -30.275 8.954 1.00 51.00 ? 511 ASN B O 1 ATOM 3655 C CB . ASN B 2 131 ? -14.258 -29.311 10.085 1.00 41.67 ? 511 ASN B CB 1 ATOM 3656 C CG . ASN B 2 131 ? -13.297 -28.456 10.873 1.00 42.34 ? 511 ASN B CG 1 ATOM 3657 O OD1 . ASN B 2 131 ? -13.090 -27.273 10.581 1.00 35.91 ? 511 ASN B OD1 1 ATOM 3658 N ND2 . ASN B 2 131 ? -12.723 -29.059 11.909 1.00 43.85 ? 511 ASN B ND2 1 ATOM 3659 N N . VAL B 2 132 ? -12.432 -29.422 6.887 1.00 39.46 ? 512 VAL B N 1 ATOM 3660 C CA . VAL B 2 132 ? -11.214 -29.926 6.255 1.00 36.46 ? 512 VAL B CA 1 ATOM 3661 C C . VAL B 2 132 ? -10.860 -29.034 5.073 1.00 34.29 ? 512 VAL B C 1 ATOM 3662 O O . VAL B 2 132 ? -11.740 -28.566 4.359 1.00 29.89 ? 512 VAL B O 1 ATOM 3663 C CB . VAL B 2 132 ? -11.403 -31.373 5.751 1.00 37.38 ? 512 VAL B CB 1 ATOM 3664 C CG1 . VAL B 2 132 ? -12.449 -31.442 4.638 1.00 40.79 ? 512 VAL B CG1 1 ATOM 3665 C CG2 . VAL B 2 132 ? -10.101 -31.955 5.250 1.00 40.44 ? 512 VAL B CG2 1 ATOM 3666 N N . THR B 2 133 ? -9.563 -28.842 4.861 1.00 33.57 ? 513 THR B N 1 ATOM 3667 C CA . THR B 2 133 ? -9.052 -28.087 3.737 1.00 30.32 ? 513 THR B CA 1 ATOM 3668 C C . THR B 2 133 ? -8.568 -29.028 2.640 1.00 31.41 ? 513 THR B C 1 ATOM 3669 O O . THR B 2 133 ? -7.581 -29.745 2.809 1.00 34.79 ? 513 THR B O 1 ATOM 3670 C CB . THR B 2 133 ? -7.917 -27.149 4.185 1.00 28.58 ? 513 THR B CB 1 ATOM 3671 O OG1 . THR B 2 133 ? -8.413 -26.270 5.194 1.00 31.20 ? 513 THR B OG1 1 ATOM 3672 C CG2 . THR B 2 133 ? -7.414 -26.303 3.046 1.00 28.98 ? 513 THR B CG2 1 ATOM 3673 N N . THR B 2 134 ? -9.244 -28.994 1.495 1.00 28.89 ? 514 THR B N 1 ATOM 3674 C CA . THR B 2 134 ? -8.865 -29.802 0.362 1.00 28.37 ? 514 THR B CA 1 ATOM 3675 C C . THR B 2 134 ? -7.932 -29.011 -0.572 1.00 27.75 ? 514 THR B C 1 ATOM 3676 O O . THR B 2 134 ? -8.192 -27.854 -0.866 1.00 28.12 ? 514 THR B O 1 ATOM 3677 C CB . THR B 2 134 ? -10.101 -30.285 -0.397 1.00 29.54 ? 514 THR B CB 1 ATOM 3678 O OG1 . THR B 2 134 ? -10.970 -30.978 0.509 1.00 31.25 ? 514 THR B OG1 1 ATOM 3679 C CG2 . THR B 2 134 ? -9.700 -31.246 -1.455 1.00 31.09 ? 514 THR B CG2 1 ATOM 3680 N N . VAL B 2 135 ? -6.832 -29.628 -0.990 1.00 25.15 ? 515 VAL B N 1 ATOM 3681 C CA . VAL B 2 135 ? -5.896 -28.995 -1.893 1.00 26.16 ? 515 VAL B CA 1 ATOM 3682 C C . VAL B 2 135 ? -5.712 -29.871 -3.092 1.00 26.39 ? 515 VAL B C 1 ATOM 3683 O O . VAL B 2 135 ? -5.748 -31.094 -2.964 1.00 27.82 ? 515 VAL B O 1 ATOM 3684 C CB . VAL B 2 135 ? -4.505 -28.766 -1.257 1.00 26.41 ? 515 VAL B CB 1 ATOM 3685 C CG1 . VAL B 2 135 ? -4.632 -27.926 -0.022 1.00 26.11 ? 515 VAL B CG1 1 ATOM 3686 C CG2 . VAL B 2 135 ? -3.794 -30.086 -0.935 1.00 26.58 ? 515 VAL B CG2 1 ATOM 3687 N N . GLU B 2 136 ? -5.494 -29.258 -4.248 1.00 27.02 ? 516 GLU B N 1 ATOM 3688 C CA . GLU B 2 136 ? -5.215 -30.025 -5.465 1.00 29.85 ? 516 GLU B CA 1 ATOM 3689 C C . GLU B 2 136 ? -3.841 -30.675 -5.405 1.00 32.48 ? 516 GLU B C 1 ATOM 3690 O O . GLU B 2 136 ? -2.975 -30.260 -4.644 1.00 34.29 ? 516 GLU B O 1 ATOM 3691 C CB . GLU B 2 136 ? -5.322 -29.154 -6.729 1.00 27.49 ? 516 GLU B CB 1 ATOM 3692 C CG . GLU B 2 136 ? -6.759 -28.896 -7.110 1.00 27.49 ? 516 GLU B CG 1 ATOM 3693 C CD . GLU B 2 136 ? -6.908 -28.130 -8.393 1.00 27.17 ? 516 GLU B CD 1 ATOM 3694 O OE1 . GLU B 2 136 ? -6.259 -27.061 -8.547 1.00 25.42 ? 516 GLU B OE1 1 ATOM 3695 O OE2 . GLU B 2 136 ? -7.712 -28.600 -9.243 1.00 27.25 ? 516 GLU B OE2 1 ATOM 3696 N N . ARG B 2 137 ? -3.645 -31.644 -6.280 1.00 37.36 ? 517 ARG B N 1 ATOM 3697 C CA . ARG B 2 137 ? -2.458 -32.503 -6.294 1.00 41.22 ? 517 ARG B CA 1 ATOM 3698 C C . ARG B 2 137 ? -1.142 -31.762 -6.533 1.00 40.33 ? 517 ARG B C 1 ATOM 3699 O O . ARG B 2 137 ? -0.126 -32.118 -5.975 1.00 43.94 ? 517 ARG B O 1 ATOM 3700 C CB . ARG B 2 137 ? -2.647 -33.590 -7.362 1.00 45.17 ? 517 ARG B CB 1 ATOM 3701 C CG . ARG B 2 137 ? -1.953 -34.901 -7.054 1.00 54.93 ? 517 ARG B CG 1 ATOM 3702 C CD . ARG B 2 137 ? -2.399 -35.997 -8.013 1.00 63.52 ? 517 ARG B CD 1 ATOM 3703 N NE . ARG B 2 137 ? -3.861 -36.045 -8.147 1.00 67.26 ? 517 ARG B NE 1 ATOM 3704 C CZ . ARG B 2 137 ? -4.565 -35.603 -9.192 1.00 67.09 ? 517 ARG B CZ 1 ATOM 3705 N NH1 . ARG B 2 137 ? -3.977 -35.068 -10.261 1.00 66.72 ? 517 ARG B NH1 1 ATOM 3706 N NH2 . ARG B 2 137 ? -5.885 -35.707 -9.164 1.00 68.83 ? 517 ARG B NH2 1 ATOM 3707 N N . ASN B 2 138 ? -1.158 -30.720 -7.342 1.00 37.98 ? 518 ASN B N 1 ATOM 3708 C CA . ASN B 2 138 ? 0.080 -30.036 -7.696 1.00 38.16 ? 518 ASN B CA 1 ATOM 3709 C C . ASN B 2 138 ? 0.273 -28.704 -6.980 1.00 33.86 ? 518 ASN B C 1 ATOM 3710 O O . ASN B 2 138 ? 1.038 -27.843 -7.441 1.00 30.92 ? 518 ASN B O 1 ATOM 3711 C CB . ASN B 2 138 ? 0.124 -29.823 -9.211 1.00 43.15 ? 518 ASN B CB 1 ATOM 3712 C CG . ASN B 2 138 ? -1.123 -29.125 -9.736 1.00 54.60 ? 518 ASN B CG 1 ATOM 3713 O OD1 . ASN B 2 138 ? -2.173 -29.096 -9.063 1.00 61.60 ? 518 ASN B OD1 1 ATOM 3714 N ND2 . ASN B 2 138 ? -1.032 -28.578 -10.954 1.00 61.77 ? 518 ASN B ND2 1 ATOM 3715 N N . ILE B 2 139 ? -0.442 -28.509 -5.877 1.00 30.29 ? 519 ILE B N 1 ATOM 3716 C CA . ILE B 2 139 ? -0.279 -27.278 -5.099 1.00 30.45 ? 519 ILE B CA 1 ATOM 3717 C C . ILE B 2 139 ? 1.155 -27.153 -4.580 1.00 30.49 ? 519 ILE B C 1 ATOM 3718 O O . ILE B 2 139 ? 1.781 -28.142 -4.226 1.00 31.73 ? 519 ILE B O 1 ATOM 3719 C CB . ILE B 2 139 ? -1.272 -27.235 -3.918 1.00 30.64 ? 519 ILE B CB 1 ATOM 3720 C CG1 . ILE B 2 139 ? -1.446 -25.802 -3.416 1.00 31.84 ? 519 ILE B CG1 1 ATOM 3721 C CG2 . ILE B 2 139 ? -0.847 -28.182 -2.796 1.00 30.27 ? 519 ILE B CG2 1 ATOM 3722 C CD1 . ILE B 2 139 ? -2.754 -25.581 -2.699 1.00 32.54 ? 519 ILE B CD1 1 ATOM 3723 N N . ASP B 2 140 ? 1.679 -25.938 -4.556 1.00 31.07 ? 520 ASP B N 1 ATOM 3724 C CA . ASP B 2 140 ? 2.973 -25.670 -3.931 1.00 30.82 ? 520 ASP B CA 1 ATOM 3725 C C . ASP B 2 140 ? 2.953 -26.283 -2.521 1.00 29.88 ? 520 ASP B C 1 ATOM 3726 O O . ASP B 2 140 ? 2.134 -25.908 -1.681 1.00 28.15 ? 520 ASP B O 1 ATOM 3727 C CB . ASP B 2 140 ? 3.196 -24.154 -3.884 1.00 30.31 ? 520 ASP B CB 1 ATOM 3728 C CG . ASP B 2 140 ? 4.545 -23.755 -3.297 1.00 32.45 ? 520 ASP B CG 1 ATOM 3729 O OD1 . ASP B 2 140 ? 5.246 -24.620 -2.716 1.00 32.13 ? 520 ASP B OD1 1 ATOM 3730 O OD2 . ASP B 2 140 ? 4.890 -22.540 -3.421 1.00 32.60 ? 520 ASP B OD2 1 ATOM 3731 N N . GLN B 2 141 ? 3.832 -27.238 -2.254 1.00 28.99 ? 521 GLN B N 1 ATOM 3732 C CA . GLN B 2 141 ? 3.761 -27.924 -0.967 1.00 30.35 ? 521 GLN B CA 1 ATOM 3733 C C . GLN B 2 141 ? 4.255 -27.085 0.192 1.00 27.68 ? 521 GLN B C 1 ATOM 3734 O O . GLN B 2 141 ? 4.057 -27.464 1.325 1.00 28.81 ? 521 GLN B O 1 ATOM 3735 C CB . GLN B 2 141 ? 4.463 -29.276 -1.002 1.00 32.26 ? 521 GLN B CB 1 ATOM 3736 C CG . GLN B 2 141 ? 3.764 -30.281 -1.903 1.00 36.26 ? 521 GLN B CG 1 ATOM 3737 C CD . GLN B 2 141 ? 4.705 -31.373 -2.337 1.00 37.28 ? 521 GLN B CD 1 ATOM 3738 O OE1 . GLN B 2 141 ? 4.596 -32.517 -1.892 1.00 36.43 ? 521 GLN B OE1 1 ATOM 3739 N NE2 . GLN B 2 141 ? 5.669 -31.012 -3.184 1.00 35.76 ? 521 GLN B NE2 1 ATOM 3740 N N . ALA B 2 142 ? 4.854 -25.938 -0.082 1.00 27.07 ? 522 ALA B N 1 ATOM 3741 C CA . ALA B 2 142 ? 5.099 -24.954 0.977 1.00 28.76 ? 522 ALA B CA 1 ATOM 3742 C C . ALA B 2 142 ? 3.761 -24.356 1.499 1.00 28.56 ? 522 ALA B C 1 ATOM 3743 O O . ALA B 2 142 ? 3.631 -23.963 2.676 1.00 27.50 ? 522 ALA B O 1 ATOM 3744 C CB . ALA B 2 142 ? 6.042 -23.855 0.495 1.00 29.30 ? 522 ALA B CB 1 ATOM 3745 N N . VAL B 2 143 ? 2.760 -24.303 0.632 1.00 29.21 ? 523 VAL B N 1 ATOM 3746 C CA . VAL B 2 143 ? 1.424 -23.903 1.064 1.00 28.52 ? 523 VAL B CA 1 ATOM 3747 C C . VAL B 2 143 ? 0.806 -24.945 2.003 1.00 27.03 ? 523 VAL B C 1 ATOM 3748 O O . VAL B 2 143 ? 0.287 -24.613 3.064 1.00 26.21 ? 523 VAL B O 1 ATOM 3749 C CB . VAL B 2 143 ? 0.521 -23.633 -0.143 1.00 28.15 ? 523 VAL B CB 1 ATOM 3750 C CG1 . VAL B 2 143 ? -0.929 -23.542 0.282 1.00 29.27 ? 523 VAL B CG1 1 ATOM 3751 C CG2 . VAL B 2 143 ? 0.970 -22.356 -0.823 1.00 27.31 ? 523 VAL B CG2 1 ATOM 3752 N N . THR B 2 144 ? 0.924 -26.205 1.633 1.00 26.75 ? 524 THR B N 1 ATOM 3753 C CA . THR B 2 144 ? 0.440 -27.296 2.443 1.00 28.68 ? 524 THR B CA 1 ATOM 3754 C C . THR B 2 144 ? 1.087 -27.260 3.826 1.00 29.61 ? 524 THR B C 1 ATOM 3755 O O . THR B 2 144 ? 0.411 -27.406 4.840 1.00 29.49 ? 524 THR B O 1 ATOM 3756 C CB . THR B 2 144 ? 0.742 -28.639 1.735 1.00 30.63 ? 524 THR B CB 1 ATOM 3757 O OG1 . THR B 2 144 ? -0.002 -28.693 0.515 1.00 31.52 ? 524 THR B OG1 1 ATOM 3758 C CG2 . THR B 2 144 ? 0.377 -29.842 2.601 1.00 30.31 ? 524 THR B CG2 1 ATOM 3759 N N . ALA B 2 145 ? 2.398 -27.046 3.859 1.00 29.03 ? 525 ALA B N 1 ATOM 3760 C CA . ALA B 2 145 ? 3.132 -26.923 5.128 1.00 29.05 ? 525 ALA B CA 1 ATOM 3761 C C . ALA B 2 145 ? 2.681 -25.711 5.973 1.00 27.99 ? 525 ALA B C 1 ATOM 3762 O O . ALA B 2 145 ? 2.469 -25.827 7.178 1.00 28.04 ? 525 ALA B O 1 ATOM 3763 C CB . ALA B 2 145 ? 4.633 -26.865 4.845 1.00 28.61 ? 525 ALA B CB 1 ATOM 3764 N N . ALA B 2 146 ? 2.511 -24.559 5.331 1.00 28.80 ? 526 ALA B N 1 ATOM 3765 C CA . ALA B 2 146 ? 2.021 -23.362 5.999 1.00 27.78 ? 526 ALA B CA 1 ATOM 3766 C C . ALA B 2 146 ? 0.638 -23.575 6.640 1.00 27.14 ? 526 ALA B C 1 ATOM 3767 O O . ALA B 2 146 ? 0.337 -23.057 7.726 1.00 27.40 ? 526 ALA B O 1 ATOM 3768 C CB . ALA B 2 146 ? 1.971 -22.212 5.000 1.00 29.02 ? 526 ALA B CB 1 ATOM 3769 N N . LEU B 2 147 ? -0.203 -24.334 5.955 1.00 28.23 ? 527 LEU B N 1 ATOM 3770 C CA . LEU B 2 147 ? -1.531 -24.660 6.451 1.00 27.91 ? 527 LEU B CA 1 ATOM 3771 C C . LEU B 2 147 ? -1.439 -25.631 7.598 1.00 26.99 ? 527 LEU B C 1 ATOM 3772 O O . LEU B 2 147 ? -2.024 -25.411 8.642 1.00 26.33 ? 527 LEU B O 1 ATOM 3773 C CB . LEU B 2 147 ? -2.400 -25.232 5.327 1.00 27.55 ? 527 LEU B CB 1 ATOM 3774 C CG . LEU B 2 147 ? -2.749 -24.272 4.169 1.00 29.42 ? 527 LEU B CG 1 ATOM 3775 C CD1 . LEU B 2 147 ? -3.383 -25.028 3.020 1.00 29.42 ? 527 LEU B CD1 1 ATOM 3776 C CD2 . LEU B 2 147 ? -3.673 -23.141 4.601 1.00 29.08 ? 527 LEU B CD2 1 ATOM 3777 N N . GLU B 2 148 ? -0.691 -26.708 7.423 1.00 27.27 ? 528 GLU B N 1 ATOM 3778 C CA . GLU B 2 148 ? -0.624 -27.744 8.466 1.00 27.82 ? 528 GLU B CA 1 ATOM 3779 C C . GLU B 2 148 ? 0.018 -27.240 9.745 1.00 27.46 ? 528 GLU B C 1 ATOM 3780 O O . GLU B 2 148 ? -0.405 -27.611 10.829 1.00 27.24 ? 528 GLU B O 1 ATOM 3781 C CB . GLU B 2 148 ? 0.120 -28.975 7.950 1.00 30.08 ? 528 GLU B CB 1 ATOM 3782 C CG . GLU B 2 148 ? -0.616 -29.728 6.845 1.00 31.78 ? 528 GLU B CG 1 ATOM 3783 C CD . GLU B 2 148 ? -1.572 -30.778 7.367 1.00 34.20 ? 528 GLU B CD 1 ATOM 3784 O OE1 . GLU B 2 148 ? -1.464 -31.147 8.552 1.00 36.07 ? 528 GLU B OE1 1 ATOM 3785 O OE2 . GLU B 2 148 ? -2.443 -31.232 6.586 1.00 37.78 ? 528 GLU B OE2 1 ATOM 3786 N N . THR B 2 149 ? 1.021 -26.373 9.634 1.00 28.28 ? 529 THR B N 1 ATOM 3787 C CA . THR B 2 149 ? 1.652 -25.847 10.832 1.00 29.95 ? 529 THR B CA 1 ATOM 3788 C C . THR B 2 149 ? 0.730 -24.836 11.525 1.00 30.89 ? 529 THR B C 1 ATOM 3789 O O . THR B 2 149 ? 0.926 -24.540 12.692 1.00 31.58 ? 529 THR B O 1 ATOM 3790 C CB . THR B 2 149 ? 3.034 -25.190 10.574 1.00 31.00 ? 529 THR B CB 1 ATOM 3791 O OG1 . THR B 2 149 ? 2.910 -24.132 9.620 1.00 31.48 ? 529 THR B OG1 1 ATOM 3792 C CG2 . THR B 2 149 ? 4.068 -26.224 10.071 1.00 32.03 ? 529 THR B CG2 1 ATOM 3793 N N . ARG B 2 150 ? -0.245 -24.295 10.805 1.00 29.45 ? 530 ARG B N 1 ATOM 3794 C CA . ARG B 2 150 ? -1.284 -23.498 11.424 1.00 29.37 ? 530 ARG B CA 1 ATOM 3795 C C . ARG B 2 150 ? -2.529 -24.317 11.813 1.00 29.40 ? 530 ARG B C 1 ATOM 3796 O O . ARG B 2 150 ? -3.601 -23.757 12.060 1.00 28.09 ? 530 ARG B O 1 ATOM 3797 C CB . ARG B 2 150 ? -1.651 -22.360 10.509 1.00 29.93 ? 530 ARG B CB 1 ATOM 3798 C CG . ARG B 2 150 ? -0.543 -21.341 10.407 1.00 29.28 ? 530 ARG B CG 1 ATOM 3799 C CD . ARG B 2 150 ? -0.936 -20.283 9.394 1.00 29.78 ? 530 ARG B CD 1 ATOM 3800 N NE . ARG B 2 150 ? 0.057 -19.228 9.329 1.00 28.90 ? 530 ARG B NE 1 ATOM 3801 C CZ . ARG B 2 150 ? 1.204 -19.298 8.657 1.00 29.39 ? 530 ARG B CZ 1 ATOM 3802 N NH1 . ARG B 2 150 ? 1.546 -20.397 7.964 1.00 29.20 ? 530 ARG B NH1 1 ATOM 3803 N NH2 . ARG B 2 150 ? 2.017 -18.251 8.687 1.00 28.61 ? 530 ARG B NH2 1 ATOM 3804 N N . HIS B 2 151 ? -2.350 -25.632 11.891 1.00 28.33 ? 531 HIS B N 1 ATOM 3805 C CA . HIS B 2 151 ? -3.347 -26.574 12.402 1.00 30.45 ? 531 HIS B CA 1 ATOM 3806 C C . HIS B 2 151 ? -4.491 -26.870 11.440 1.00 31.04 ? 531 HIS B C 1 ATOM 3807 O O . HIS B 2 151 ? -5.506 -27.405 11.866 1.00 29.71 ? 531 HIS B O 1 ATOM 3808 C CB . HIS B 2 151 ? -3.863 -26.159 13.785 1.00 32.49 ? 531 HIS B CB 1 ATOM 3809 C CG . HIS B 2 151 ? -2.763 -25.837 14.744 1.00 37.21 ? 531 HIS B CG 1 ATOM 3810 N ND1 . HIS B 2 151 ? -2.533 -24.560 15.214 1.00 42.15 ? 531 HIS B ND1 1 ATOM 3811 C CD2 . HIS B 2 151 ? -1.763 -26.605 15.235 1.00 38.59 ? 531 HIS B CD2 1 ATOM 3812 C CE1 . HIS B 2 151 ? -1.453 -24.562 15.977 1.00 43.52 ? 531 HIS B CE1 1 ATOM 3813 N NE2 . HIS B 2 151 ? -0.965 -25.791 16.001 1.00 42.46 ? 531 HIS B NE2 1 ATOM 3814 N N . HIS B 2 152 ? -4.331 -26.584 10.147 1.00 29.60 ? 532 HIS B N 1 ATOM 3815 C CA . HIS B 2 152 ? -5.311 -27.100 9.178 1.00 31.42 ? 532 HIS B CA 1 ATOM 3816 C C . HIS B 2 152 ? -5.002 -28.552 8.920 1.00 33.23 ? 532 HIS B C 1 ATOM 3817 O O . HIS B 2 152 ? -3.848 -28.876 8.675 1.00 34.77 ? 532 HIS B O 1 ATOM 3818 C CB . HIS B 2 152 ? -5.219 -26.388 7.826 1.00 30.80 ? 532 HIS B CB 1 ATOM 3819 C CG . HIS B 2 152 ? -5.538 -24.929 7.865 1.00 31.11 ? 532 HIS B CG 1 ATOM 3820 N ND1 . HIS B 2 152 ? -6.789 -24.442 7.561 1.00 31.96 ? 532 HIS B ND1 1 ATOM 3821 C CD2 . HIS B 2 152 ? -4.761 -23.846 8.110 1.00 31.12 ? 532 HIS B CD2 1 ATOM 3822 C CE1 . HIS B 2 152 ? -6.775 -23.124 7.638 1.00 32.30 ? 532 HIS B CE1 1 ATOM 3823 N NE2 . HIS B 2 152 ? -5.554 -22.737 7.956 1.00 30.95 ? 532 HIS B NE2 1 ATOM 3824 N N . HIS B 2 153 ? -6.009 -29.424 8.955 1.00 35.03 ? 533 HIS B N 1 ATOM 3825 C CA A HIS B 2 153 ? -5.845 -30.789 8.433 0.50 35.33 ? 533 HIS B CA 1 ATOM 3826 C CA B HIS B 2 153 ? -5.851 -30.774 8.464 0.50 36.00 ? 533 HIS B CA 1 ATOM 3827 C C . HIS B 2 153 ? -6.158 -30.715 6.971 1.00 35.75 ? 533 HIS B C 1 ATOM 3828 O O . HIS B 2 153 ? -7.267 -30.343 6.583 1.00 38.69 ? 533 HIS B O 1 ATOM 3829 C CB A HIS B 2 153 ? -6.761 -31.840 9.084 0.50 36.42 ? 533 HIS B CB 1 ATOM 3830 C CB B HIS B 2 153 ? -6.772 -31.727 9.243 0.50 37.98 ? 533 HIS B CB 1 ATOM 3831 C CG A HIS B 2 153 ? -6.683 -33.188 8.418 0.50 36.81 ? 533 HIS B CG 1 ATOM 3832 C CG B HIS B 2 153 ? -6.463 -31.790 10.715 0.50 39.18 ? 533 HIS B CG 1 ATOM 3833 N ND1 A HIS B 2 153 ? -5.484 -33.827 8.164 0.50 36.90 ? 533 HIS B ND1 1 ATOM 3834 N ND1 B HIS B 2 153 ? -5.313 -32.368 11.212 0.50 39.92 ? 533 HIS B ND1 1 ATOM 3835 C CD2 A HIS B 2 153 ? -7.651 -34.001 7.926 0.50 36.03 ? 533 HIS B CD2 1 ATOM 3836 C CD2 B HIS B 2 153 ? -7.150 -31.343 11.794 0.50 41.06 ? 533 HIS B CD2 1 ATOM 3837 C CE1 A HIS B 2 153 ? -5.717 -34.971 7.546 0.50 36.19 ? 533 HIS B CE1 1 ATOM 3838 C CE1 B HIS B 2 153 ? -5.305 -32.274 12.530 0.50 40.24 ? 533 HIS B CE1 1 ATOM 3839 N NE2 A HIS B 2 153 ? -7.023 -35.102 7.392 0.50 35.69 ? 533 HIS B NE2 1 ATOM 3840 N NE2 B HIS B 2 153 ? -6.409 -31.657 12.908 0.50 40.84 ? 533 HIS B NE2 1 ATOM 3841 N N . THR B 2 154 ? -5.173 -31.021 6.138 1.00 33.68 ? 534 THR B N 1 ATOM 3842 C CA . THR B 2 154 ? -5.410 -30.978 4.725 1.00 33.57 ? 534 THR B CA 1 ATOM 3843 C C . THR B 2 154 ? -5.538 -32.378 4.169 1.00 35.83 ? 534 THR B C 1 ATOM 3844 O O . THR B 2 154 ? -5.029 -33.354 4.738 1.00 37.77 ? 534 THR B O 1 ATOM 3845 C CB . THR B 2 154 ? -4.310 -30.234 3.968 1.00 33.95 ? 534 THR B CB 1 ATOM 3846 O OG1 . THR B 2 154 ? -3.088 -30.947 4.107 1.00 35.69 ? 534 THR B OG1 1 ATOM 3847 C CG2 . THR B 2 154 ? -4.134 -28.833 4.516 1.00 34.50 ? 534 THR B CG2 1 ATOM 3848 N N . GLN B 2 155 ? -6.266 -32.463 3.067 1.00 35.87 ? 535 GLN B N 1 ATOM 3849 C CA . GLN B 2 155 ? -6.244 -33.620 2.226 1.00 37.35 ? 535 GLN B CA 1 ATOM 3850 C C . GLN B 2 155 ? -6.277 -33.231 0.770 1.00 38.32 ? 535 GLN B C 1 ATOM 3851 O O . GLN B 2 155 ? -6.692 -32.128 0.393 1.00 36.85 ? 535 GLN B O 1 ATOM 3852 C CB . GLN B 2 155 ? -7.375 -34.571 2.549 1.00 42.84 ? 535 GLN B CB 1 ATOM 3853 C CG . GLN B 2 155 ? -8.768 -34.012 2.506 1.00 46.25 ? 535 GLN B CG 1 ATOM 3854 C CD . GLN B 2 155 ? -9.738 -34.928 3.251 1.00 53.34 ? 535 GLN B CD 1 ATOM 3855 O OE1 . GLN B 2 155 ? -9.482 -35.344 4.390 1.00 58.31 ? 535 GLN B OE1 1 ATOM 3856 N NE2 . GLN B 2 155 ? -10.854 -35.238 2.617 1.00 54.61 ? 535 GLN B NE2 1 ATOM 3857 N N . ILE B 2 156 ? -5.814 -34.175 -0.033 1.00 37.16 ? 536 ILE B N 1 ATOM 3858 C CA . ILE B 2 156 ? -5.557 -33.977 -1.424 1.00 36.64 ? 536 ILE B CA 1 ATOM 3859 C C . ILE B 2 156 ? -6.776 -34.452 -2.187 1.00 37.77 ? 536 ILE B C 1 ATOM 3860 O O . ILE B 2 156 ? -7.358 -35.468 -1.840 1.00 36.74 ? 536 ILE B O 1 ATOM 3861 C CB . ILE B 2 156 ? -4.300 -34.738 -1.837 1.00 37.05 ? 536 ILE B CB 1 ATOM 3862 C CG1 . ILE B 2 156 ? -3.108 -34.196 -1.020 1.00 40.09 ? 536 ILE B CG1 1 ATOM 3863 C CG2 . ILE B 2 156 ? -4.054 -34.614 -3.338 1.00 35.39 ? 536 ILE B CG2 1 ATOM 3864 C CD1 . ILE B 2 156 ? -1.853 -35.050 -1.102 1.00 43.08 ? 536 ILE B CD1 1 ATOM 3865 N N . ALA B 2 157 ? -7.193 -33.667 -3.183 1.00 36.26 ? 537 ALA B N 1 ATOM 3866 C CA . ALA B 2 157 ? -8.359 -33.999 -3.974 1.00 38.68 ? 537 ALA B CA 1 ATOM 3867 C C . ALA B 2 157 ? -7.941 -35.104 -4.925 1.00 39.40 ? 537 ALA B C 1 ATOM 3868 O O . ALA B 2 157 ? -6.919 -34.998 -5.590 1.00 40.36 ? 537 ALA B O 1 ATOM 3869 C CB . ALA B 2 157 ? -8.847 -32.775 -4.742 1.00 39.40 ? 537 ALA B CB 1 ATOM 3870 N N . SER B 2 158 ? -8.729 -36.164 -4.974 1.00 44.86 ? 538 SER B N 1 ATOM 3871 C CA . SER B 2 158 ? -8.409 -37.319 -5.814 1.00 51.02 ? 538 SER B CA 1 ATOM 3872 C C . SER B 2 158 ? -8.461 -36.976 -7.295 1.00 49.40 ? 538 SER B C 1 ATOM 3873 O O . SER B 2 158 ? -7.711 -37.563 -8.076 1.00 53.13 ? 538 SER B O 1 ATOM 3874 C CB . SER B 2 158 ? -9.357 -38.484 -5.529 1.00 53.04 ? 538 SER B CB 1 ATOM 3875 O OG . SER B 2 158 ? -10.693 -38.075 -5.755 1.00 59.76 ? 538 SER B OG 1 ATOM 3876 N N . THR B 2 159 ? -9.322 -36.034 -7.686 1.00 42.63 ? 539 THR B N 1 ATOM 3877 C CA . THR B 2 159 ? -9.338 -35.570 -9.075 1.00 41.15 ? 539 THR B CA 1 ATOM 3878 C C . THR B 2 159 ? -8.848 -34.133 -9.210 1.00 39.30 ? 539 THR B C 1 ATOM 3879 O O . THR B 2 159 ? -7.658 -33.903 -9.397 1.00 35.79 ? 539 THR B O 1 ATOM 3880 C CB . THR B 2 159 ? -10.728 -35.756 -9.740 1.00 40.73 ? 539 THR B CB 1 ATOM 3881 O OG1 . THR B 2 159 ? -11.737 -35.090 -8.977 1.00 40.56 ? 539 THR B OG1 1 ATOM 3882 C CG2 . THR B 2 159 ? -11.086 -37.257 -9.832 1.00 42.42 ? 539 THR B CG2 1 ATOM 3883 N N . PHE B 2 160 ? -9.778 -33.180 -9.143 1.00 37.31 ? 540 PHE B N 1 ATOM 3884 C CA . PHE B 2 160 ? -9.470 -31.773 -9.295 1.00 34.72 ? 540 PHE B CA 1 ATOM 3885 C C . PHE B 2 160 ? -10.565 -30.975 -8.604 1.00 32.44 ? 540 PHE B C 1 ATOM 3886 O O . PHE B 2 160 ? -11.646 -31.501 -8.344 1.00 29.32 ? 540 PHE B O 1 ATOM 3887 C CB . PHE B 2 160 ? -9.344 -31.390 -10.781 1.00 35.24 ? 540 PHE B CB 1 ATOM 3888 C CG . PHE B 2 160 ? -10.591 -31.665 -11.615 1.00 38.10 ? 540 PHE B CG 1 ATOM 3889 C CD1 . PHE B 2 160 ? -11.667 -30.777 -11.620 1.00 33.65 ? 540 PHE B CD1 1 ATOM 3890 C CD2 . PHE B 2 160 ? -10.663 -32.806 -12.452 1.00 40.52 ? 540 PHE B CD2 1 ATOM 3891 C CE1 . PHE B 2 160 ? -12.799 -31.025 -12.402 1.00 36.65 ? 540 PHE B CE1 1 ATOM 3892 C CE2 . PHE B 2 160 ? -11.791 -33.052 -13.238 1.00 41.09 ? 540 PHE B CE2 1 ATOM 3893 C CZ . PHE B 2 160 ? -12.871 -32.165 -13.200 1.00 38.59 ? 540 PHE B CZ 1 ATOM 3894 N N . ILE B 2 161 ? -10.276 -29.709 -8.329 1.00 29.19 ? 541 ILE B N 1 ATOM 3895 C CA . ILE B 2 161 ? -11.221 -28.768 -7.704 1.00 27.43 ? 541 ILE B CA 1 ATOM 3896 C C . ILE B 2 161 ? -11.708 -27.753 -8.758 1.00 26.92 ? 541 ILE B C 1 ATOM 3897 O O . ILE B 2 161 ? -10.952 -26.892 -9.193 1.00 25.73 ? 541 ILE B O 1 ATOM 3898 C CB . ILE B 2 161 ? -10.544 -28.053 -6.510 1.00 26.65 ? 541 ILE B CB 1 ATOM 3899 C CG1 . ILE B 2 161 ? -10.131 -29.082 -5.454 1.00 27.34 ? 541 ILE B CG1 1 ATOM 3900 C CG2 . ILE B 2 161 ? -11.447 -27.024 -5.848 1.00 26.03 ? 541 ILE B CG2 1 ATOM 3901 C CD1 . ILE B 2 161 ? -9.355 -28.461 -4.300 1.00 28.57 ? 541 ILE B CD1 1 ATOM 3902 N N . ALA B 2 162 ? -12.960 -27.936 -9.192 1.00 26.90 ? 542 ALA B N 1 ATOM 3903 C CA . ALA B 2 162 ? -13.720 -27.016 -10.042 1.00 25.59 ? 542 ALA B CA 1 ATOM 3904 C C . ALA B 2 162 ? -13.205 -26.910 -11.466 1.00 25.23 ? 542 ALA B C 1 ATOM 3905 O O . ALA B 2 162 ? -12.213 -27.544 -11.848 1.00 24.52 ? 542 ALA B O 1 ATOM 3906 C CB . ALA B 2 162 ? -13.807 -25.635 -9.412 1.00 26.66 ? 542 ALA B CB 1 ATOM 3907 N N . VAL B 2 163 ? -13.952 -26.145 -12.259 1.00 23.22 ? 543 VAL B N 1 ATOM 3908 C CA . VAL B 2 163 ? -13.623 -25.844 -13.622 1.00 25.18 ? 543 VAL B CA 1 ATOM 3909 C C . VAL B 2 163 ? -13.940 -24.378 -13.864 1.00 25.90 ? 543 VAL B C 1 ATOM 3910 O O . VAL B 2 163 ? -15.104 -23.934 -13.671 1.00 26.13 ? 543 VAL B O 1 ATOM 3911 C CB . VAL B 2 163 ? -14.457 -26.710 -14.593 1.00 26.70 ? 543 VAL B CB 1 ATOM 3912 C CG1 . VAL B 2 163 ? -14.038 -26.456 -16.026 1.00 26.83 ? 543 VAL B CG1 1 ATOM 3913 C CG2 . VAL B 2 163 ? -14.311 -28.177 -14.239 1.00 27.32 ? 543 VAL B CG2 1 ATOM 3914 N N . VAL B 2 164 ? -12.921 -23.626 -14.282 1.00 25.61 ? 544 VAL B N 1 ATOM 3915 C CA . VAL B 2 164 ? -13.070 -22.195 -14.525 1.00 25.36 ? 544 VAL B CA 1 ATOM 3916 C C . VAL B 2 164 ? -12.867 -21.803 -15.985 1.00 24.72 ? 544 VAL B C 1 ATOM 3917 O O . VAL B 2 164 ? -11.872 -22.152 -16.592 1.00 26.11 ? 544 VAL B O 1 ATOM 3918 C CB . VAL B 2 164 ? -12.102 -21.392 -13.659 1.00 26.21 ? 544 VAL B CB 1 ATOM 3919 C CG1 . VAL B 2 164 ? -12.235 -19.898 -13.952 1.00 26.48 ? 544 VAL B CG1 1 ATOM 3920 C CG2 . VAL B 2 164 ? -12.363 -21.693 -12.191 1.00 26.83 ? 544 VAL B CG2 1 ATOM 3921 N N . GLN B 2 165 ? -13.831 -21.066 -16.536 1.00 24.97 ? 545 GLN B N 1 ATOM 3922 C CA . GLN B 2 165 ? -13.673 -20.405 -17.826 1.00 24.65 ? 545 GLN B CA 1 ATOM 3923 C C . GLN B 2 165 ? -13.621 -18.898 -17.611 1.00 25.02 ? 545 GLN B C 1 ATOM 3924 O O . GLN B 2 165 ? -14.475 -18.344 -16.892 1.00 25.38 ? 545 GLN B O 1 ATOM 3925 C CB . GLN B 2 165 ? -14.807 -20.771 -18.767 1.00 23.88 ? 545 GLN B CB 1 ATOM 3926 C CG . GLN B 2 165 ? -14.511 -21.983 -19.634 1.00 24.39 ? 545 GLN B CG 1 ATOM 3927 C CD . GLN B 2 165 ? -14.464 -23.271 -18.857 1.00 25.71 ? 545 GLN B CD 1 ATOM 3928 O OE1 . GLN B 2 165 ? -13.431 -23.964 -18.799 1.00 26.67 ? 545 GLN B OE1 1 ATOM 3929 N NE2 . GLN B 2 165 ? -15.596 -23.616 -18.242 1.00 25.38 ? 545 GLN B NE2 1 ATOM 3930 N N . ALA B 2 166 ? -12.651 -18.232 -18.241 1.00 23.06 ? 546 ALA B N 1 ATOM 3931 C CA . ALA B 2 166 ? -12.450 -16.802 -17.996 1.00 24.31 ? 546 ALA B CA 1 ATOM 3932 C C . ALA B 2 166 ? -11.938 -16.001 -19.183 1.00 24.18 ? 546 ALA B C 1 ATOM 3933 O O . ALA B 2 166 ? -11.222 -16.505 -20.037 1.00 23.97 ? 546 ALA B O 1 ATOM 3934 C CB . ALA B 2 166 ? -11.502 -16.605 -16.827 1.00 24.64 ? 546 ALA B CB 1 ATOM 3935 N N . ILE B 2 167 ? -12.325 -14.734 -19.209 1.00 25.00 ? 547 ILE B N 1 ATOM 3936 C CA . ILE B 2 167 ? -11.812 -13.756 -20.175 1.00 25.53 ? 547 ILE B CA 1 ATOM 3937 C C . ILE B 2 167 ? -11.412 -12.491 -19.418 1.00 26.97 ? 547 ILE B C 1 ATOM 3938 O O . ILE B 2 167 ? -12.139 -12.037 -18.526 1.00 26.72 ? 547 ILE B O 1 ATOM 3939 C CB . ILE B 2 167 ? -12.845 -13.378 -21.222 1.00 25.19 ? 547 ILE B CB 1 ATOM 3940 C CG1 . ILE B 2 167 ? -13.267 -14.604 -22.026 1.00 26.31 ? 547 ILE B CG1 1 ATOM 3941 C CG2 . ILE B 2 167 ? -12.296 -12.285 -22.138 1.00 27.08 ? 547 ILE B CG2 1 ATOM 3942 C CD1 . ILE B 2 167 ? -14.490 -14.361 -22.883 1.00 27.34 ? 547 ILE B CD1 1 ATOM 3943 N N . VAL B 2 168 ? -10.271 -11.926 -19.808 1.00 27.75 ? 548 VAL B N 1 ATOM 3944 C CA . VAL B 2 168 ? -9.678 -10.769 -19.158 1.00 29.33 ? 548 VAL B CA 1 ATOM 3945 C C . VAL B 2 168 ? -9.163 -9.782 -20.199 1.00 31.63 ? 548 VAL B C 1 ATOM 3946 O O . VAL B 2 168 ? -8.495 -10.177 -21.159 1.00 28.94 ? 548 VAL B O 1 ATOM 3947 C CB . VAL B 2 168 ? -8.493 -11.180 -18.272 1.00 28.00 ? 548 VAL B CB 1 ATOM 3948 C CG1 . VAL B 2 168 ? -7.688 -9.968 -17.828 1.00 29.27 ? 548 VAL B CG1 1 ATOM 3949 C CG2 . VAL B 2 168 ? -8.978 -11.948 -17.062 1.00 28.73 ? 548 VAL B CG2 1 ATOM 3950 N N . ARG B 2 169 ? -9.456 -8.497 -19.995 1.00 32.80 ? 549 ARG B N 1 ATOM 3951 C CA . ARG B 2 169 ? -8.979 -7.482 -20.908 1.00 36.33 ? 549 ARG B CA 1 ATOM 3952 C C . ARG B 2 169 ? -7.503 -7.224 -20.670 1.00 36.08 ? 549 ARG B C 1 ATOM 3953 O O . ARG B 2 169 ? -7.077 -7.072 -19.517 1.00 34.64 ? 549 ARG B O 1 ATOM 3954 C CB . ARG B 2 169 ? -9.753 -6.178 -20.765 1.00 39.17 ? 549 ARG B CB 1 ATOM 3955 C CG . ARG B 2 169 ? -9.575 -5.283 -21.980 1.00 42.72 ? 549 ARG B CG 1 ATOM 3956 C CD . ARG B 2 169 ? -10.414 -4.026 -21.897 1.00 45.62 ? 549 ARG B CD 1 ATOM 3957 N NE . ARG B 2 169 ? -9.743 -2.973 -21.128 1.00 48.87 ? 549 ARG B NE 1 ATOM 3958 C CZ . ARG B 2 169 ? -10.132 -2.491 -19.939 1.00 50.94 ? 549 ARG B CZ 1 ATOM 3959 N NH1 . ARG B 2 169 ? -11.215 -2.952 -19.290 1.00 45.38 ? 549 ARG B NH1 1 ATOM 3960 N NH2 . ARG B 2 169 ? -9.406 -1.523 -19.380 1.00 52.00 ? 549 ARG B NH2 1 ATOM 3961 N N . THR B 2 170 ? -6.739 -7.180 -21.763 1.00 35.86 ? 550 THR B N 1 ATOM 3962 C CA . THR B 2 170 ? -5.333 -6.787 -21.732 1.00 40.68 ? 550 THR B CA 1 ATOM 3963 C C . THR B 2 170 ? -5.081 -5.712 -22.775 1.00 41.57 ? 550 THR B C 1 ATOM 3964 O O . THR B 2 170 ? -5.963 -5.392 -23.561 1.00 40.60 ? 550 THR B O 1 ATOM 3965 C CB . THR B 2 170 ? -4.393 -7.983 -22.011 1.00 41.87 ? 550 THR B CB 1 ATOM 3966 O OG1 . THR B 2 170 ? -4.667 -8.522 -23.305 1.00 40.74 ? 550 THR B OG1 1 ATOM 3967 C CG2 . THR B 2 170 ? -4.604 -9.071 -20.965 1.00 42.30 ? 550 THR B CG2 1 ATOM 3968 N N . ALA B 2 171 ? -3.878 -5.150 -22.774 1.00 44.53 ? 551 ALA B N 1 ATOM 3969 C CA . ALA B 2 171 ? -3.498 -4.173 -23.802 1.00 47.40 ? 551 ALA B CA 1 ATOM 3970 C C . ALA B 2 171 ? -3.576 -4.829 -25.185 1.00 44.79 ? 551 ALA B C 1 ATOM 3971 O O . ALA B 2 171 ? -3.999 -4.206 -26.135 1.00 48.52 ? 551 ALA B O 1 ATOM 3972 C CB . ALA B 2 171 ? -2.101 -3.619 -23.533 1.00 47.16 ? 551 ALA B CB 1 ATOM 3973 N N . GLY B 2 172 ? -3.240 -6.109 -25.271 1.00 48.01 ? 552 GLY B N 1 ATOM 3974 C CA . GLY B 2 172 ? -3.420 -6.881 -26.512 1.00 50.55 ? 552 GLY B CA 1 ATOM 3975 C C . GLY B 2 172 ? -4.832 -7.318 -26.906 1.00 52.26 ? 552 GLY B C 1 ATOM 3976 O O . GLY B 2 172 ? -4.997 -8.003 -27.917 1.00 55.41 ? 552 GLY B O 1 ATOM 3977 N N . GLY B 2 173 ? -5.851 -6.948 -26.126 1.00 48.53 ? 553 GLY B N 1 ATOM 3978 C CA . GLY B 2 173 ? -7.244 -7.295 -26.441 1.00 45.17 ? 553 GLY B CA 1 ATOM 3979 C C . GLY B 2 173 ? -7.875 -8.167 -25.364 1.00 40.01 ? 553 GLY B C 1 ATOM 3980 O O . GLY B 2 173 ? -7.757 -7.881 -24.178 1.00 43.35 ? 553 GLY B O 1 ATOM 3981 N N . TRP B 2 174 ? -8.546 -9.231 -25.774 1.00 34.28 ? 554 TRP B N 1 ATOM 3982 C CA . TRP B 2 174 ? -9.277 -10.080 -24.844 1.00 31.01 ? 554 TRP B CA 1 ATOM 3983 C C . TRP B 2 174 ? -8.559 -11.410 -24.711 1.00 29.88 ? 554 TRP B C 1 ATOM 3984 O O . TRP B 2 174 ? -8.550 -12.215 -25.650 1.00 33.44 ? 554 TRP B O 1 ATOM 3985 C CB . TRP B 2 174 ? -10.712 -10.315 -25.318 1.00 30.89 ? 554 TRP B CB 1 ATOM 3986 C CG . TRP B 2 174 ? -11.488 -9.088 -25.516 1.00 32.39 ? 554 TRP B CG 1 ATOM 3987 C CD1 . TRP B 2 174 ? -11.837 -8.539 -26.705 1.00 35.15 ? 554 TRP B CD1 1 ATOM 3988 C CD2 . TRP B 2 174 ? -12.018 -8.227 -24.508 1.00 34.11 ? 554 TRP B CD2 1 ATOM 3989 N NE1 . TRP B 2 174 ? -12.559 -7.393 -26.509 1.00 36.48 ? 554 TRP B NE1 1 ATOM 3990 C CE2 . TRP B 2 174 ? -12.675 -7.173 -25.165 1.00 35.57 ? 554 TRP B CE2 1 ATOM 3991 C CE3 . TRP B 2 174 ? -12.013 -8.247 -23.113 1.00 34.07 ? 554 TRP B CE3 1 ATOM 3992 C CZ2 . TRP B 2 174 ? -13.318 -6.152 -24.479 1.00 35.82 ? 554 TRP B CZ2 1 ATOM 3993 C CZ3 . TRP B 2 174 ? -12.664 -7.233 -22.432 1.00 32.40 ? 554 TRP B CZ3 1 ATOM 3994 C CH2 . TRP B 2 174 ? -13.307 -6.206 -23.115 1.00 33.57 ? 554 TRP B CH2 1 ATOM 3995 N N . ALA B 2 175 ? -7.980 -11.651 -23.546 1.00 26.51 ? 555 ALA B N 1 ATOM 3996 C CA . ALA B 2 175 ? -7.303 -12.912 -23.280 1.00 28.07 ? 555 ALA B CA 1 ATOM 3997 C C . ALA B 2 175 ? -8.290 -13.909 -22.685 1.00 28.02 ? 555 ALA B C 1 ATOM 3998 O O . ALA B 2 175 ? -8.946 -13.596 -21.696 1.00 28.77 ? 555 ALA B O 1 ATOM 3999 C CB . ALA B 2 175 ? -6.137 -12.681 -22.329 1.00 27.91 ? 555 ALA B CB 1 ATOM 4000 N N . ALA B 2 176 ? -8.394 -15.089 -23.300 1.00 28.03 ? 556 ALA B N 1 ATOM 4001 C CA . ALA B 2 176 ? -9.329 -16.145 -22.898 1.00 28.80 ? 556 ALA B CA 1 ATOM 4002 C C . ALA B 2 176 ? -8.630 -17.418 -22.437 1.00 28.69 ? 556 ALA B C 1 ATOM 4003 O O . ALA B 2 176 ? -7.564 -17.769 -22.959 1.00 28.65 ? 556 ALA B O 1 ATOM 4004 C CB . ALA B 2 176 ? -10.248 -16.492 -24.062 1.00 30.35 ? 556 ALA B CB 1 ATOM 4005 N N . ALA B 2 177 ? -9.255 -18.120 -21.489 1.00 26.32 ? 557 ALA B N 1 ATOM 4006 C CA . ALA B 2 177 ? -8.761 -19.413 -21.007 1.00 26.53 ? 557 ALA B CA 1 ATOM 4007 C C . ALA B 2 177 ? -9.886 -20.353 -20.619 1.00 25.77 ? 557 ALA B C 1 ATOM 4008 O O . ALA B 2 177 ? -10.831 -19.962 -19.944 1.00 27.26 ? 557 ALA B O 1 ATOM 4009 C CB . ALA B 2 177 ? -7.827 -19.215 -19.824 1.00 28.12 ? 557 ALA B CB 1 ATOM 4010 N N . SER B 2 178 ? -9.802 -21.588 -21.093 1.00 25.27 ? 558 SER B N 1 ATOM 4011 C CA . SER B 2 178 ? -10.661 -22.643 -20.622 1.00 25.43 ? 558 SER B CA 1 ATOM 4012 C C . SER B 2 178 ? -9.775 -23.605 -19.828 1.00 26.44 ? 558 SER B C 1 ATOM 4013 O O . SER B 2 178 ? -8.582 -23.725 -20.086 1.00 28.41 ? 558 SER B O 1 ATOM 4014 C CB . SER B 2 178 ? -11.355 -23.340 -21.780 1.00 24.71 ? 558 SER B CB 1 ATOM 4015 O OG . SER B 2 178 ? -12.015 -22.413 -22.623 1.00 25.56 ? 558 SER B OG 1 ATOM 4016 N N . ASP B 2 179 ? -10.385 -24.271 -18.861 1.00 25.16 ? 559 ASP B N 1 ATOM 4017 C CA . ASP B 2 179 ? -9.704 -25.091 -17.872 1.00 25.55 ? 559 ASP B CA 1 ATOM 4018 C C . ASP B 2 179 ? -9.324 -26.474 -18.421 1.00 26.69 ? 559 ASP B C 1 ATOM 4019 O O . ASP B 2 179 ? -10.191 -27.267 -18.823 1.00 25.31 ? 559 ASP B O 1 ATOM 4020 C CB . ASP B 2 179 ? -10.649 -25.276 -16.694 1.00 25.04 ? 559 ASP B CB 1 ATOM 4021 C CG . ASP B 2 179 ? -9.957 -25.617 -15.417 1.00 26.00 ? 559 ASP B CG 1 ATOM 4022 O OD1 . ASP B 2 179 ? -9.008 -26.433 -15.428 1.00 25.16 ? 559 ASP B OD1 1 ATOM 4023 O OD2 . ASP B 2 179 ? -10.422 -25.109 -14.367 1.00 24.38 ? 559 ASP B OD2 1 ATOM 4024 N N . SER B 2 180 ? -8.034 -26.785 -18.365 1.00 26.68 ? 560 SER B N 1 ATOM 4025 C CA . SER B 2 180 ? -7.526 -28.061 -18.837 1.00 27.41 ? 560 SER B CA 1 ATOM 4026 C C . SER B 2 180 ? -8.016 -29.208 -17.978 1.00 29.06 ? 560 SER B C 1 ATOM 4027 O O . SER B 2 180 ? -7.982 -30.356 -18.398 1.00 29.14 ? 560 SER B O 1 ATOM 4028 C CB . SER B 2 180 ? -6.013 -28.051 -18.844 1.00 29.00 ? 560 SER B CB 1 ATOM 4029 O OG . SER B 2 180 ? -5.508 -28.105 -17.523 1.00 29.73 ? 560 SER B OG 1 ATOM 4030 N N . ARG B 2 181 ? -8.511 -28.923 -16.782 1.00 28.63 ? 561 ARG B N 1 ATOM 4031 C CA . ARG B 2 181 ? -9.061 -30.008 -15.968 1.00 28.45 ? 561 ARG B CA 1 ATOM 4032 C C . ARG B 2 181 ? -10.241 -30.710 -16.662 1.00 29.63 ? 561 ARG B C 1 ATOM 4033 O O . ARG B 2 181 ? -10.478 -31.878 -16.415 1.00 32.39 ? 561 ARG B O 1 ATOM 4034 C CB . ARG B 2 181 ? -9.500 -29.489 -14.610 1.00 27.35 ? 561 ARG B CB 1 ATOM 4035 C CG . ARG B 2 181 ? -8.375 -29.045 -13.672 1.00 26.72 ? 561 ARG B CG 1 ATOM 4036 C CD . ARG B 2 181 ? -8.966 -28.086 -12.630 1.00 26.00 ? 561 ARG B CD 1 ATOM 4037 N NE . ARG B 2 181 ? -8.003 -27.445 -11.734 1.00 25.31 ? 561 ARG B NE 1 ATOM 4038 C CZ . ARG B 2 181 ? -7.331 -26.323 -11.991 1.00 25.87 ? 561 ARG B CZ 1 ATOM 4039 N NH1 . ARG B 2 181 ? -6.516 -25.823 -11.063 1.00 25.83 ? 561 ARG B NH1 1 ATOM 4040 N NH2 . ARG B 2 181 ? -7.452 -25.691 -13.161 1.00 26.40 ? 561 ARG B NH2 1 ATOM 4041 N N . LYS B 2 182 ? -10.998 -29.986 -17.486 1.00 29.35 ? 562 LYS B N 1 ATOM 4042 C CA . LYS B 2 182 ? -12.120 -30.555 -18.254 1.00 30.81 ? 562 LYS B CA 1 ATOM 4043 C C . LYS B 2 182 ? -11.816 -30.655 -19.775 1.00 30.63 ? 562 LYS B C 1 ATOM 4044 O O . LYS B 2 182 ? -12.435 -31.447 -20.458 1.00 34.73 ? 562 LYS B O 1 ATOM 4045 C CB . LYS B 2 182 ? -13.407 -29.730 -18.019 1.00 32.97 ? 562 LYS B CB 1 ATOM 4046 C CG . LYS B 2 182 ? -14.720 -30.375 -18.508 1.00 34.49 ? 562 LYS B CG 1 ATOM 4047 C CD . LYS B 2 182 ? -15.982 -29.544 -18.171 1.00 35.88 ? 562 LYS B CD 1 ATOM 4048 C CE . LYS B 2 182 ? -17.300 -30.317 -18.359 1.00 36.57 ? 562 LYS B CE 1 ATOM 4049 N NZ . LYS B 2 182 ? -18.552 -29.495 -18.449 1.00 36.25 ? 562 LYS B NZ 1 ATOM 4050 N N . GLY B 2 183 ? -10.902 -29.849 -20.308 1.00 30.21 ? 563 GLY B N 1 ATOM 4051 C CA . GLY B 2 183 ? -10.398 -30.042 -21.680 1.00 31.81 ? 563 GLY B CA 1 ATOM 4052 C C . GLY B 2 183 ? -10.936 -29.028 -22.681 1.00 32.36 ? 563 GLY B C 1 ATOM 4053 O O . GLY B 2 183 ? -10.764 -29.173 -23.880 1.00 32.60 ? 563 GLY B O 1 ATOM 4054 N N . GLY B 2 184 ? -11.616 -27.999 -22.205 1.00 31.69 ? 564 GLY B N 1 ATOM 4055 C CA . GLY B 2 184 ? -12.128 -26.988 -23.107 1.00 30.42 ? 564 GLY B CA 1 ATOM 4056 C C . GLY B 2 184 ? -11.020 -26.169 -23.738 1.00 30.43 ? 564 GLY B C 1 ATOM 4057 O O . GLY B 2 184 ? -9.857 -26.216 -23.334 1.00 30.08 ? 564 GLY B O 1 ATOM 4058 N N . GLU B 2 185 ? -11.403 -25.400 -24.736 1.00 30.51 ? 565 GLU B N 1 ATOM 4059 C CA . GLU B 2 185 ? -10.503 -24.469 -25.354 1.00 33.66 ? 565 GLU B CA 1 ATOM 4060 C C . GLU B 2 185 ? -11.384 -23.327 -25.839 1.00 29.86 ? 565 GLU B C 1 ATOM 4061 O O . GLU B 2 185 ? -12.494 -23.550 -26.309 1.00 29.75 ? 565 GLU B O 1 ATOM 4062 C CB . GLU B 2 185 ? -9.719 -25.147 -26.507 1.00 38.11 ? 565 GLU B CB 1 ATOM 4063 C CG . GLU B 2 185 ? -8.765 -24.224 -27.248 1.00 47.90 ? 565 GLU B CG 1 ATOM 4064 C CD . GLU B 2 185 ? -7.933 -24.912 -28.349 1.00 58.71 ? 565 GLU B CD 1 ATOM 4065 O OE1 . GLU B 2 185 ? -7.853 -26.170 -28.366 1.00 65.68 ? 565 GLU B OE1 1 ATOM 4066 O OE2 . GLU B 2 185 ? -7.347 -24.182 -29.193 1.00 59.21 ? 565 GLU B OE2 1 ATOM 4067 N N . PRO B 2 186 ? -10.903 -22.098 -25.710 1.00 27.94 ? 566 PRO B N 1 ATOM 4068 C CA . PRO B 2 186 ? -11.599 -20.946 -26.247 1.00 28.57 ? 566 PRO B CA 1 ATOM 4069 C C . PRO B 2 186 ? -11.466 -20.761 -27.740 1.00 29.16 ? 566 PRO B C 1 ATOM 4070 O O . PRO B 2 186 ? -10.697 -21.457 -28.399 1.00 27.56 ? 566 PRO B O 1 ATOM 4071 C CB . PRO B 2 186 ? -10.919 -19.765 -25.575 1.00 28.34 ? 566 PRO B CB 1 ATOM 4072 C CG . PRO B 2 186 ? -9.797 -20.317 -24.789 1.00 28.74 ? 566 PRO B CG 1 ATOM 4073 C CD . PRO B 2 186 ? -9.608 -21.739 -25.135 1.00 28.71 ? 566 PRO B CD 1 ATOM 4074 N N . ALA B 2 187 ? -12.228 -19.796 -28.244 1.00 29.12 ? 567 ALA B N 1 ATOM 4075 C CA . ALA B 2 187 ? -12.132 -19.338 -29.613 1.00 30.21 ? 567 ALA B CA 1 ATOM 4076 C C . ALA B 2 187 ? -12.503 -17.852 -29.660 1.00 32.22 ? 567 ALA B C 1 ATOM 4077 O O . ALA B 2 187 ? -13.168 -17.323 -28.747 1.00 30.60 ? 567 ALA B O 1 ATOM 4078 C CB . ALA B 2 187 ? -13.039 -20.153 -30.513 1.00 31.45 ? 567 ALA B CB 1 ATOM 4079 N N . GLY B 2 188 ? -12.046 -17.181 -30.711 1.00 32.05 ? 568 GLY B N 1 ATOM 4080 C CA . GLY B 2 188 ? -12.300 -15.767 -30.896 1.00 33.89 ? 568 GLY B CA 1 ATOM 4081 C C . GLY B 2 188 ? -11.805 -15.278 -32.248 1.00 35.84 ? 568 GLY B C 1 ATOM 4082 O O . GLY B 2 188 ? -11.480 -16.081 -33.125 1.00 33.62 ? 568 GLY B O 1 ATOM 4083 N N . TYR B 2 189 ? -11.803 -13.960 -32.415 1.00 38.48 ? 569 TYR B N 1 ATOM 4084 C CA . TYR B 2 189 ? -11.215 -13.293 -33.574 1.00 40.26 ? 569 TYR B CA 1 ATOM 4085 C C . TYR B 2 189 ? -10.821 -11.870 -33.221 1.00 43.16 ? 569 TYR B C 1 ATOM 4086 O O . TYR B 2 189 ? -10.169 -11.230 -34.046 1.00 45.41 ? 569 TYR B O 1 ATOM 4087 C CB . TYR B 2 189 ? -12.171 -13.283 -34.762 1.00 38.50 ? 569 TYR B CB 1 ATOM 4088 C CG . TYR B 2 189 ? -13.496 -12.574 -34.534 1.00 38.11 ? 569 TYR B CG 1 ATOM 4089 C CD1 . TYR B 2 189 ? -14.547 -13.218 -33.913 1.00 38.00 ? 569 TYR B CD1 1 ATOM 4090 C CD2 . TYR B 2 189 ? -13.709 -11.278 -34.989 1.00 38.39 ? 569 TYR B CD2 1 ATOM 4091 C CE1 . TYR B 2 189 ? -15.762 -12.593 -33.727 1.00 37.50 ? 569 TYR B CE1 1 ATOM 4092 C CE2 . TYR B 2 189 ? -14.926 -10.638 -34.798 1.00 37.92 ? 569 TYR B CE2 1 ATOM 4093 C CZ . TYR B 2 189 ? -15.949 -11.302 -34.167 1.00 38.40 ? 569 TYR B CZ 1 ATOM 4094 O OH . TYR B 2 189 ? -17.159 -10.674 -33.954 1.00 39.81 ? 569 TYR B OH 1 ATOM 4095 O OXT . TYR B 2 189 ? -11.139 -11.336 -32.140 1.00 41.71 ? 569 TYR B OXT 1 HETATM 4096 C C1 . NAG C 3 . ? -27.710 -2.320 -24.993 1.00 81.29 ? 601 NAG A C1 1 HETATM 4097 C C2 . NAG C 3 . ? -27.850 -3.190 -26.224 1.00 84.33 ? 601 NAG A C2 1 HETATM 4098 C C3 . NAG C 3 . ? -28.047 -2.310 -27.448 1.00 91.90 ? 601 NAG A C3 1 HETATM 4099 C C4 . NAG C 3 . ? -29.249 -1.382 -27.225 1.00 95.30 ? 601 NAG A C4 1 HETATM 4100 C C5 . NAG C 3 . ? -29.149 -0.659 -25.874 1.00 93.07 ? 601 NAG A C5 1 HETATM 4101 C C6 . NAG C 3 . ? -30.417 0.138 -25.552 1.00 88.03 ? 601 NAG A C6 1 HETATM 4102 C C7 . NAG C 3 . ? -26.874 -5.418 -26.380 1.00 75.64 ? 601 NAG A C7 1 HETATM 4103 C C8 . NAG C 3 . ? -25.619 -6.219 -26.590 1.00 71.41 ? 601 NAG A C8 1 HETATM 4104 N N2 . NAG C 3 . ? -26.722 -4.090 -26.392 1.00 74.62 ? 601 NAG A N2 1 HETATM 4105 O O3 . NAG C 3 . ? -28.259 -3.163 -28.549 1.00 99.23 ? 601 NAG A O3 1 HETATM 4106 O O4 . NAG C 3 . ? -29.358 -0.432 -28.267 1.00 91.28 ? 601 NAG A O4 1 HETATM 4107 O O5 . NAG C 3 . ? -28.908 -1.592 -24.830 1.00 90.89 ? 601 NAG A O5 1 HETATM 4108 O O6 . NAG C 3 . ? -30.954 -0.247 -24.298 1.00 79.06 ? 601 NAG A O6 1 HETATM 4109 O O7 . NAG C 3 . ? -27.963 -5.986 -26.216 1.00 69.35 ? 601 NAG A O7 1 HETATM 4110 C C1 . NAG D 3 . ? -40.965 -39.584 3.523 1.00 53.87 ? 602 NAG A C1 1 HETATM 4111 C C2 . NAG D 3 . ? -41.813 -39.975 2.315 1.00 54.01 ? 602 NAG A C2 1 HETATM 4112 C C3 . NAG D 3 . ? -43.054 -39.065 2.221 1.00 52.75 ? 602 NAG A C3 1 HETATM 4113 C C4 . NAG D 3 . ? -43.789 -38.946 3.558 1.00 52.86 ? 602 NAG A C4 1 HETATM 4114 C C5 . NAG D 3 . ? -42.787 -38.624 4.699 1.00 54.89 ? 602 NAG A C5 1 HETATM 4115 C C6 . NAG D 3 . ? -43.432 -38.600 6.090 1.00 53.15 ? 602 NAG A C6 1 HETATM 4116 C C7 . NAG D 3 . ? -40.411 -40.866 0.460 1.00 57.62 ? 602 NAG A C7 1 HETATM 4117 C C8 . NAG D 3 . ? -39.799 -40.500 -0.869 1.00 56.23 ? 602 NAG A C8 1 HETATM 4118 N N2 . NAG D 3 . ? -41.088 -39.877 1.053 1.00 54.08 ? 602 NAG A N2 1 HETATM 4119 O O3 . NAG D 3 . ? -43.928 -39.473 1.182 1.00 47.95 ? 602 NAG A O3 1 HETATM 4120 O O4 . NAG D 3 . ? -44.783 -37.949 3.429 1.00 44.60 ? 602 NAG A O4 1 HETATM 4121 O O5 . NAG D 3 . ? -41.709 -39.558 4.719 1.00 50.98 ? 602 NAG A O5 1 HETATM 4122 O O6 . NAG D 3 . ? -43.840 -39.903 6.456 1.00 51.82 ? 602 NAG A O6 1 HETATM 4123 O O7 . NAG D 3 . ? -40.264 -42.000 0.941 1.00 65.41 ? 602 NAG A O7 1 HETATM 4124 C C1 . NAG E 3 . ? -25.355 -7.952 10.698 1.00 53.96 ? 603 NAG A C1 1 HETATM 4125 C C2 . NAG E 3 . ? -26.179 -8.813 11.650 1.00 55.63 ? 603 NAG A C2 1 HETATM 4126 C C3 . NAG E 3 . ? -26.269 -8.185 13.034 1.00 54.23 ? 603 NAG A C3 1 HETATM 4127 C C4 . NAG E 3 . ? -24.905 -7.770 13.562 1.00 54.14 ? 603 NAG A C4 1 HETATM 4128 C C5 . NAG E 3 . ? -24.113 -6.930 12.555 1.00 56.17 ? 603 NAG A C5 1 HETATM 4129 C C6 . NAG E 3 . ? -22.647 -6.771 12.979 1.00 54.23 ? 603 NAG A C6 1 HETATM 4130 C C7 . NAG E 3 . ? -27.999 -10.127 10.661 1.00 55.02 ? 603 NAG A C7 1 HETATM 4131 C C8 . NAG E 3 . ? -29.409 -10.093 10.147 1.00 55.92 ? 603 NAG A C8 1 HETATM 4132 N N2 . NAG E 3 . ? -27.517 -8.969 11.114 1.00 54.74 ? 603 NAG A N2 1 HETATM 4133 O O3 . NAG E 3 . ? -26.813 -9.150 13.896 1.00 51.87 ? 603 NAG A O3 1 HETATM 4134 O O4 . NAG E 3 . ? -25.170 -7.017 14.711 1.00 53.43 ? 603 NAG A O4 1 HETATM 4135 O O5 . NAG E 3 . ? -24.113 -7.532 11.267 1.00 55.57 ? 603 NAG A O5 1 HETATM 4136 O O6 . NAG E 3 . ? -21.981 -5.899 12.077 1.00 54.17 ? 603 NAG A O6 1 HETATM 4137 O O7 . NAG E 3 . ? -27.358 -11.183 10.644 1.00 57.77 ? 603 NAG A O7 1 HETATM 4138 C C1 . NAG F 3 . ? -24.296 -1.490 -6.418 1.00 63.57 ? 604 NAG A C1 1 HETATM 4139 C C2 . NAG F 3 . ? -24.635 -0.444 -7.477 1.00 73.23 ? 604 NAG A C2 1 HETATM 4140 C C3 . NAG F 3 . ? -25.317 0.787 -6.845 1.00 78.14 ? 604 NAG A C3 1 HETATM 4141 C C4 . NAG F 3 . ? -26.093 0.534 -5.523 1.00 80.16 ? 604 NAG A C4 1 HETATM 4142 C C5 . NAG F 3 . ? -25.960 -0.855 -4.853 1.00 77.55 ? 604 NAG A C5 1 HETATM 4143 C C6 . NAG F 3 . ? -27.254 -1.288 -4.139 1.00 72.76 ? 604 NAG A C6 1 HETATM 4144 C C7 . NAG F 3 . ? -23.357 -0.075 -9.578 1.00 65.10 ? 604 NAG A C7 1 HETATM 4145 C C8 . NAG F 3 . ? -22.055 0.380 -10.181 1.00 63.44 ? 604 NAG A C8 1 HETATM 4146 N N2 . NAG F 3 . ? -23.440 -0.045 -8.237 1.00 68.86 ? 604 NAG A N2 1 HETATM 4147 O O3 . NAG F 3 . ? -26.164 1.405 -7.807 1.00 74.42 ? 604 NAG A O3 1 HETATM 4148 O O4 . NAG F 3 . ? -25.664 1.489 -4.565 1.00 87.86 ? 604 NAG A O4 1 HETATM 4149 O O5 . NAG F 3 . ? -25.490 -1.857 -5.745 1.00 73.65 ? 604 NAG A O5 1 HETATM 4150 O O6 . NAG F 3 . ? -28.198 -1.820 -5.050 1.00 71.38 ? 604 NAG A O6 1 HETATM 4151 O O7 . NAG F 3 . ? -24.270 -0.455 -10.318 1.00 55.54 ? 604 NAG A O7 1 HETATM 4152 C C1 . NAG G 3 . ? -51.138 -24.394 -22.872 1.00 70.83 ? 605 NAG A C1 1 HETATM 4153 C C2 . NAG G 3 . ? -51.684 -25.725 -22.357 1.00 76.55 ? 605 NAG A C2 1 HETATM 4154 C C3 . NAG G 3 . ? -53.188 -25.539 -22.227 1.00 77.92 ? 605 NAG A C3 1 HETATM 4155 C C4 . NAG G 3 . ? -53.443 -24.507 -21.137 1.00 78.64 ? 605 NAG A C4 1 HETATM 4156 C C5 . NAG G 3 . ? -52.806 -23.147 -21.460 1.00 81.46 ? 605 NAG A C5 1 HETATM 4157 C C6 . NAG G 3 . ? -52.424 -22.356 -20.201 1.00 82.93 ? 605 NAG A C6 1 HETATM 4158 C C7 . NAG G 3 . ? -50.265 -27.678 -23.063 1.00 69.85 ? 605 NAG A C7 1 HETATM 4159 C C8 . NAG G 3 . ? -50.039 -28.744 -24.109 1.00 69.17 ? 605 NAG A C8 1 HETATM 4160 N N2 . NAG G 3 . ? -51.304 -26.828 -23.260 1.00 72.77 ? 605 NAG A N2 1 HETATM 4161 O O3 . NAG G 3 . ? -53.795 -26.768 -21.916 1.00 79.47 ? 605 NAG A O3 1 HETATM 4162 O O4 . NAG G 3 . ? -54.834 -24.327 -21.018 1.00 83.12 ? 605 NAG A O4 1 HETATM 4163 O O5 . NAG G 3 . ? -51.675 -23.171 -22.336 1.00 77.18 ? 605 NAG A O5 1 HETATM 4164 O O6 . NAG G 3 . ? -51.397 -21.429 -20.496 1.00 85.09 ? 605 NAG A O6 1 HETATM 4165 O O7 . NAG G 3 . ? -49.492 -27.643 -22.095 1.00 58.71 ? 605 NAG A O7 1 HETATM 4166 CL CL . CL H 4 . ? -30.606 -38.290 -27.920 1.00 27.33 ? 606 CL A CL 1 HETATM 4167 CL CL . CL I 4 . ? -17.390 -25.767 -17.248 1.00 55.52 ? 607 CL A CL 1 HETATM 4168 NA NA . NA J 5 . ? -5.694 -19.758 -23.036 1.00 52.79 ? 608 NA A NA 1 HETATM 4169 C C1 . NAG K 3 . ? -11.817 -28.438 12.823 1.00 46.70 ? 1101 NAG B C1 1 HETATM 4170 C C2 . NAG K 3 . ? -11.834 -29.241 14.130 1.00 48.33 ? 1101 NAG B C2 1 HETATM 4171 C C3 . NAG K 3 . ? -11.102 -28.441 15.197 1.00 48.95 ? 1101 NAG B C3 1 HETATM 4172 C C4 . NAG K 3 . ? -9.717 -28.049 14.723 1.00 53.24 ? 1101 NAG B C4 1 HETATM 4173 C C5 . NAG K 3 . ? -9.717 -27.569 13.273 1.00 54.78 ? 1101 NAG B C5 1 HETATM 4174 C C6 . NAG K 3 . ? -8.268 -27.589 12.874 1.00 58.06 ? 1101 NAG B C6 1 HETATM 4175 C C7 . NAG K 3 . ? -14.095 -28.726 14.998 1.00 44.96 ? 1101 NAG B C7 1 HETATM 4176 C C8 . NAG K 3 . ? -15.382 -29.301 15.542 1.00 44.67 ? 1101 NAG B C8 1 HETATM 4177 N N2 . NAG K 3 . ? -13.153 -29.615 14.633 1.00 43.83 ? 1101 NAG B N2 1 HETATM 4178 O O3 . NAG K 3 . ? -11.033 -29.131 16.418 1.00 51.13 ? 1101 NAG B O3 1 HETATM 4179 O O4 . NAG K 3 . ? -9.253 -26.967 15.528 1.00 53.36 ? 1101 NAG B O4 1 HETATM 4180 O O5 . NAG K 3 . ? -10.490 -28.354 12.380 1.00 51.87 ? 1101 NAG B O5 1 HETATM 4181 O O6 . NAG K 3 . ? -7.514 -27.215 14.008 1.00 63.62 ? 1101 NAG B O6 1 HETATM 4182 O O7 . NAG K 3 . ? -13.981 -27.497 14.912 1.00 40.54 ? 1101 NAG B O7 1 HETATM 4183 N N . GLU L 6 . ? -26.384 -27.877 -8.361 1.00 38.25 ? 1102 GLU B N 1 HETATM 4184 C CA . GLU L 6 . ? -25.253 -27.240 -7.625 1.00 37.70 ? 1102 GLU B CA 1 HETATM 4185 C C . GLU L 6 . ? -25.499 -25.742 -7.532 1.00 37.44 ? 1102 GLU B C 1 HETATM 4186 O O . GLU L 6 . ? -26.330 -25.170 -8.275 1.00 33.88 ? 1102 GLU B O 1 HETATM 4187 C CB . GLU L 6 . ? -23.920 -27.516 -8.341 1.00 38.25 ? 1102 GLU B CB 1 HETATM 4188 C CG . GLU L 6 . ? -23.647 -29.009 -8.533 1.00 41.56 ? 1102 GLU B CG 1 HETATM 4189 C CD . GLU L 6 . ? -22.312 -29.333 -9.186 1.00 45.25 ? 1102 GLU B CD 1 HETATM 4190 O OE1 . GLU L 6 . ? -21.663 -28.422 -9.772 1.00 40.80 ? 1102 GLU B OE1 1 HETATM 4191 O OE2 . GLU L 6 . ? -21.909 -30.520 -9.086 1.00 48.38 ? 1102 GLU B OE2 1 HETATM 4192 O OXT . GLU L 6 . ? -24.841 -25.105 -6.710 1.00 35.55 ? 1102 GLU B OXT 1 HETATM 4193 O O . HOH M 7 . ? -30.133 -6.824 1.558 1.00 43.05 ? 701 HOH A O 1 HETATM 4194 O O . HOH M 7 . ? -36.436 -40.346 -6.314 1.00 41.73 ? 702 HOH A O 1 HETATM 4195 O O . HOH M 7 . ? -15.328 -21.202 19.557 1.00 41.82 ? 703 HOH A O 1 HETATM 4196 O O . HOH M 7 . ? -24.135 -4.036 2.654 1.00 45.40 ? 704 HOH A O 1 HETATM 4197 O O . HOH M 7 . ? -39.479 -13.953 -22.068 1.00 42.75 ? 705 HOH A O 1 HETATM 4198 O O . HOH M 7 . ? -25.098 -11.738 9.729 1.00 50.77 ? 706 HOH A O 1 HETATM 4199 O O . HOH M 7 . ? -11.049 -6.469 5.203 1.00 28.34 ? 707 HOH A O 1 HETATM 4200 O O . HOH M 7 . ? -40.117 -32.847 -31.377 1.00 22.76 ? 708 HOH A O 1 HETATM 4201 O O . HOH M 7 . ? -44.461 -37.904 -27.510 1.00 37.81 ? 709 HOH A O 1 HETATM 4202 O O . HOH M 7 . ? -25.338 -11.100 14.522 1.00 53.32 ? 710 HOH A O 1 HETATM 4203 O O . HOH M 7 . ? -48.838 -25.804 -4.569 1.00 49.93 ? 711 HOH A O 1 HETATM 4204 O O . HOH M 7 . ? -21.479 -0.272 -14.683 1.00 38.26 ? 712 HOH A O 1 HETATM 4205 O O . HOH M 7 . ? -15.201 -30.752 -22.938 1.00 44.28 ? 713 HOH A O 1 HETATM 4206 O O . HOH M 7 . ? -28.627 -39.844 -9.340 1.00 52.14 ? 714 HOH A O 1 HETATM 4207 O O . HOH M 7 . ? -9.334 2.284 -6.172 1.00 56.79 ? 715 HOH A O 1 HETATM 4208 O O . HOH M 7 . ? -32.450 -13.327 -6.815 1.00 31.45 ? 716 HOH A O 1 HETATM 4209 O O . HOH M 7 . ? -25.956 -3.926 -9.633 1.00 37.19 ? 717 HOH A O 1 HETATM 4210 O O . HOH M 7 . ? -46.436 -30.410 -9.285 1.00 29.08 ? 718 HOH A O 1 HETATM 4211 O O . HOH M 7 . ? -7.903 -17.659 11.969 1.00 25.43 ? 719 HOH A O 1 HETATM 4212 O O . HOH M 7 . ? -36.047 -16.548 -6.425 1.00 33.79 ? 720 HOH A O 1 HETATM 4213 O O . HOH M 7 . ? -31.475 -0.247 -29.758 1.00 59.74 ? 721 HOH A O 1 HETATM 4214 O O . HOH M 7 . ? -44.774 -35.615 4.861 1.00 34.79 ? 722 HOH A O 1 HETATM 4215 O O . HOH M 7 . ? -45.130 -24.632 -10.809 1.00 41.43 ? 723 HOH A O 1 HETATM 4216 O O . HOH M 7 . ? -42.995 -18.029 -26.044 1.00 47.20 ? 724 HOH A O 1 HETATM 4217 O O . HOH M 7 . ? -42.437 -13.469 -2.206 1.00 52.82 ? 725 HOH A O 1 HETATM 4218 O O . HOH M 7 . ? -7.788 -19.411 -31.300 1.00 48.23 ? 726 HOH A O 1 HETATM 4219 O O . HOH M 7 . ? 9.171 -13.172 3.223 1.00 59.19 ? 727 HOH A O 1 HETATM 4220 O O . HOH M 7 . ? -1.882 -22.024 -5.763 1.00 30.47 ? 728 HOH A O 1 HETATM 4221 O O . HOH M 7 . ? -5.317 -11.777 10.054 1.00 31.12 ? 729 HOH A O 1 HETATM 4222 O O . HOH M 7 . ? -10.174 -40.230 -21.580 1.00 52.63 ? 730 HOH A O 1 HETATM 4223 O O . HOH M 7 . ? -40.898 -34.534 -9.856 1.00 22.40 ? 731 HOH A O 1 HETATM 4224 O O . HOH M 7 . ? -22.940 -4.836 9.854 1.00 44.88 ? 732 HOH A O 1 HETATM 4225 O O . HOH M 7 . ? -39.045 -18.911 -6.483 1.00 25.80 ? 733 HOH A O 1 HETATM 4226 O O . HOH M 7 . ? 0.241 -9.526 1.376 1.00 45.04 ? 734 HOH A O 1 HETATM 4227 O O . HOH M 7 . ? -16.872 -14.978 14.723 1.00 35.57 ? 735 HOH A O 1 HETATM 4228 O O . HOH M 7 . ? -52.315 -30.864 -12.824 1.00 41.45 ? 736 HOH A O 1 HETATM 4229 O O . HOH M 7 . ? -40.848 -45.336 -11.812 1.00 45.69 ? 737 HOH A O 1 HETATM 4230 O O . HOH M 7 . ? -22.044 -1.172 -4.016 1.00 69.15 ? 738 HOH A O 1 HETATM 4231 O O . HOH M 7 . ? -27.784 -32.555 -20.426 1.00 22.76 ? 739 HOH A O 1 HETATM 4232 O O . HOH M 7 . ? -38.160 -43.077 2.962 1.00 60.97 ? 740 HOH A O 1 HETATM 4233 O O . HOH M 7 . ? -22.128 -3.116 8.121 1.00 49.24 ? 741 HOH A O 1 HETATM 4234 O O . HOH M 7 . ? -15.146 -33.796 -28.937 1.00 46.04 ? 742 HOH A O 1 HETATM 4235 O O . HOH M 7 . ? -20.953 -9.507 -32.808 1.00 39.59 ? 743 HOH A O 1 HETATM 4236 O O . HOH M 7 . ? -38.854 -34.318 -29.446 1.00 25.97 ? 744 HOH A O 1 HETATM 4237 O O . HOH M 7 . ? -28.993 -1.992 -20.365 1.00 43.36 ? 745 HOH A O 1 HETATM 4238 O O . HOH M 7 . ? -40.840 -42.412 -20.073 1.00 47.94 ? 746 HOH A O 1 HETATM 4239 O O . HOH M 7 . ? -37.183 -29.614 2.727 1.00 29.91 ? 747 HOH A O 1 HETATM 4240 O O . HOH M 7 . ? -0.519 -12.057 2.980 1.00 33.81 ? 748 HOH A O 1 HETATM 4241 O O . HOH M 7 . ? -20.160 -0.834 -6.520 1.00 40.20 ? 749 HOH A O 1 HETATM 4242 O O . HOH M 7 . ? -19.069 -17.288 -39.060 1.00 56.72 ? 750 HOH A O 1 HETATM 4243 O O . HOH M 7 . ? -14.937 0.412 -7.259 1.00 36.12 ? 751 HOH A O 1 HETATM 4244 O O . HOH M 7 . ? -15.429 -43.542 -20.299 1.00 33.28 ? 752 HOH A O 1 HETATM 4245 O O . HOH M 7 . ? -45.676 -26.452 -29.891 1.00 31.89 ? 753 HOH A O 1 HETATM 4246 O O . HOH M 7 . ? -22.980 1.358 -4.353 1.00 60.93 ? 754 HOH A O 1 HETATM 4247 O O . HOH M 7 . ? 5.571 -20.544 4.759 1.00 43.32 ? 755 HOH A O 1 HETATM 4248 O O . HOH M 7 . ? -13.262 -28.526 -32.639 1.00 45.93 ? 756 HOH A O 1 HETATM 4249 O O . HOH M 7 . ? -6.904 -27.914 -30.676 1.00 52.73 ? 757 HOH A O 1 HETATM 4250 O O . HOH M 7 . ? -31.355 -43.409 -29.727 1.00 48.29 ? 758 HOH A O 1 HETATM 4251 O O . HOH M 7 . ? -39.323 -42.034 -17.689 1.00 27.48 ? 759 HOH A O 1 HETATM 4252 O O . HOH M 7 . ? -48.421 -32.824 -2.854 1.00 28.03 ? 760 HOH A O 1 HETATM 4253 O O . HOH M 7 . ? -18.674 -7.904 2.636 1.00 23.92 ? 761 HOH A O 1 HETATM 4254 O O . HOH M 7 . ? -16.055 -33.637 -22.661 1.00 36.34 ? 762 HOH A O 1 HETATM 4255 O O . HOH M 7 . ? -43.383 -23.710 -12.414 1.00 24.77 ? 763 HOH A O 1 HETATM 4256 O O . HOH M 7 . ? -38.941 -16.519 -21.405 1.00 26.30 ? 764 HOH A O 1 HETATM 4257 O O . HOH M 7 . ? -42.898 -38.307 -1.067 1.00 30.48 ? 765 HOH A O 1 HETATM 4258 O O . HOH M 7 . ? -17.499 -34.511 -25.180 1.00 36.06 ? 766 HOH A O 1 HETATM 4259 O O . HOH M 7 . ? -42.077 -18.617 2.603 1.00 46.55 ? 767 HOH A O 1 HETATM 4260 O O . HOH M 7 . ? -25.651 -24.233 -31.261 1.00 21.54 ? 768 HOH A O 1 HETATM 4261 O O . HOH M 7 . ? -6.814 -2.696 5.587 1.00 50.87 ? 769 HOH A O 1 HETATM 4262 O O . HOH M 7 . ? -36.916 -9.026 -10.717 1.00 47.29 ? 770 HOH A O 1 HETATM 4263 O O . HOH M 7 . ? -43.658 -21.328 -19.099 1.00 27.71 ? 771 HOH A O 1 HETATM 4264 O O . HOH M 7 . ? 7.268 -11.872 -0.648 1.00 59.87 ? 772 HOH A O 1 HETATM 4265 O O . HOH M 7 . ? -25.365 -22.106 -38.376 1.00 44.95 ? 773 HOH A O 1 HETATM 4266 O O . HOH M 7 . ? -47.348 -28.685 -2.417 1.00 36.41 ? 774 HOH A O 1 HETATM 4267 O O . HOH M 7 . ? -3.496 -16.225 17.835 1.00 49.91 ? 775 HOH A O 1 HETATM 4268 O O . HOH M 7 . ? -36.525 -15.021 -28.848 1.00 45.00 ? 776 HOH A O 1 HETATM 4269 O O . HOH M 7 . ? -22.532 -20.764 -34.685 1.00 32.02 ? 777 HOH A O 1 HETATM 4270 O O . HOH M 7 . ? -21.059 -6.776 -30.900 1.00 49.46 ? 778 HOH A O 1 HETATM 4271 O O . HOH M 7 . ? -37.076 -17.764 -12.620 1.00 27.16 ? 779 HOH A O 1 HETATM 4272 O O . HOH M 7 . ? -16.634 -25.316 -36.396 1.00 56.95 ? 780 HOH A O 1 HETATM 4273 O O . HOH M 7 . ? -29.894 -23.894 -11.984 1.00 27.57 ? 781 HOH A O 1 HETATM 4274 O O . HOH M 7 . ? -29.449 -29.992 -23.935 1.00 29.88 ? 782 HOH A O 1 HETATM 4275 O O . HOH M 7 . ? -45.581 -40.168 -10.028 1.00 49.13 ? 783 HOH A O 1 HETATM 4276 O O . HOH M 7 . ? -13.741 -40.780 -13.746 1.00 43.67 ? 784 HOH A O 1 HETATM 4277 O O . HOH M 7 . ? -9.348 -24.833 8.883 1.00 29.09 ? 785 HOH A O 1 HETATM 4278 O O . HOH M 7 . ? -42.153 -19.897 -28.153 1.00 42.90 ? 786 HOH A O 1 HETATM 4279 O O . HOH M 7 . ? -19.873 -45.208 -30.507 1.00 49.28 ? 787 HOH A O 1 HETATM 4280 O O . HOH M 7 . ? -4.712 -5.255 -3.125 1.00 41.58 ? 788 HOH A O 1 HETATM 4281 O O . HOH M 7 . ? -32.318 -36.905 -35.694 1.00 32.63 ? 789 HOH A O 1 HETATM 4282 O O . HOH M 7 . ? -28.470 -32.794 -22.987 1.00 32.35 ? 790 HOH A O 1 HETATM 4283 O O . HOH M 7 . ? -45.584 -34.036 -26.002 1.00 34.93 ? 791 HOH A O 1 HETATM 4284 O O . HOH M 7 . ? -29.301 -22.254 3.770 1.00 35.00 ? 792 HOH A O 1 HETATM 4285 O O . HOH M 7 . ? -41.060 -41.693 -6.897 1.00 42.35 ? 793 HOH A O 1 HETATM 4286 O O . HOH M 7 . ? -14.177 -8.215 15.083 1.00 34.01 ? 794 HOH A O 1 HETATM 4287 O O . HOH M 7 . ? -38.769 -10.729 -15.447 1.00 42.16 ? 795 HOH A O 1 HETATM 4288 O O . HOH M 7 . ? -14.868 -34.643 -16.195 1.00 41.47 ? 796 HOH A O 1 HETATM 4289 O O . HOH M 7 . ? -9.369 -3.664 -8.483 1.00 57.90 ? 797 HOH A O 1 HETATM 4290 O O . HOH M 7 . ? -6.414 -8.073 -0.997 1.00 29.02 ? 798 HOH A O 1 HETATM 4291 O O . HOH M 7 . ? 2.350 -12.021 3.941 1.00 49.72 ? 799 HOH A O 1 HETATM 4292 O O . HOH M 7 . ? -37.537 -33.599 1.973 1.00 33.87 ? 800 HOH A O 1 HETATM 4293 O O . HOH M 7 . ? -39.895 -32.954 -7.795 1.00 23.98 ? 801 HOH A O 1 HETATM 4294 O O . HOH M 7 . ? -10.274 -19.143 -32.479 1.00 38.67 ? 802 HOH A O 1 HETATM 4295 O O . HOH M 7 . ? -19.973 -46.575 -11.611 1.00 53.69 ? 803 HOH A O 1 HETATM 4296 O O . HOH M 7 . ? -17.428 -14.240 20.509 1.00 52.65 ? 804 HOH A O 1 HETATM 4297 O O . HOH M 7 . ? -52.976 -28.643 -6.090 1.00 44.62 ? 805 HOH A O 1 HETATM 4298 O O . HOH M 7 . ? -42.791 -31.937 -31.088 1.00 35.40 ? 806 HOH A O 1 HETATM 4299 O O . HOH M 7 . ? -12.191 -36.938 -28.131 1.00 58.22 ? 807 HOH A O 1 HETATM 4300 O O . HOH M 7 . ? -47.598 -31.763 -25.533 1.00 36.60 ? 808 HOH A O 1 HETATM 4301 O O . HOH M 7 . ? -50.209 -32.570 -16.371 1.00 29.06 ? 809 HOH A O 1 HETATM 4302 O O . HOH M 7 . ? -13.327 -4.824 4.429 1.00 40.05 ? 810 HOH A O 1 HETATM 4303 O O . HOH M 7 . ? -22.887 -42.807 -32.027 1.00 50.48 ? 811 HOH A O 1 HETATM 4304 O O . HOH M 7 . ? -11.251 -38.707 -19.494 1.00 42.75 ? 812 HOH A O 1 HETATM 4305 O O . HOH M 7 . ? -35.658 -25.886 -20.464 1.00 28.47 ? 813 HOH A O 1 HETATM 4306 O O . HOH M 7 . ? -37.527 -7.778 -20.530 1.00 50.40 ? 814 HOH A O 1 HETATM 4307 O O . HOH M 7 . ? 5.321 -18.745 -5.661 1.00 55.93 ? 815 HOH A O 1 HETATM 4308 O O . HOH M 7 . ? -17.120 -3.398 -1.888 1.00 46.56 ? 816 HOH A O 1 HETATM 4309 O O . HOH M 7 . ? -26.219 -16.668 -39.575 1.00 45.39 ? 817 HOH A O 1 HETATM 4310 O O . HOH M 7 . ? -18.310 -12.409 16.710 1.00 56.10 ? 818 HOH A O 1 HETATM 4311 O O . HOH M 7 . ? -22.301 -3.649 -2.212 1.00 53.47 ? 819 HOH A O 1 HETATM 4312 O O . HOH M 7 . ? -47.445 -23.319 -10.792 1.00 46.97 ? 820 HOH A O 1 HETATM 4313 O O . HOH M 7 . ? -10.905 -21.589 -35.231 1.00 67.61 ? 821 HOH A O 1 HETATM 4314 O O . HOH M 7 . ? -28.251 -26.398 -23.606 1.00 26.19 ? 822 HOH A O 1 HETATM 4315 O O . HOH M 7 . ? -6.742 -9.023 10.311 1.00 60.55 ? 823 HOH A O 1 HETATM 4316 O O . HOH M 7 . ? -38.059 -15.278 6.331 1.00 44.47 ? 824 HOH A O 1 HETATM 4317 O O . HOH M 7 . ? -43.861 -27.840 2.289 1.00 40.26 ? 825 HOH A O 1 HETATM 4318 O O . HOH M 7 . ? -31.099 -22.077 7.827 1.00 50.41 ? 826 HOH A O 1 HETATM 4319 O O . HOH M 7 . ? -6.983 -4.893 -1.876 1.00 39.24 ? 827 HOH A O 1 HETATM 4320 O O . HOH M 7 . ? -18.279 -11.538 14.003 1.00 42.64 ? 828 HOH A O 1 HETATM 4321 O O . HOH M 7 . ? -39.721 -30.693 -35.480 1.00 43.06 ? 829 HOH A O 1 HETATM 4322 O O . HOH M 7 . ? -40.890 -33.916 -24.706 1.00 26.01 ? 830 HOH A O 1 HETATM 4323 O O . HOH M 7 . ? -29.023 -4.097 -18.217 1.00 41.71 ? 831 HOH A O 1 HETATM 4324 O O . HOH M 7 . ? -16.621 -44.777 -31.973 1.00 42.53 ? 832 HOH A O 1 HETATM 4325 O O . HOH M 7 . ? -46.194 -41.305 -16.983 1.00 29.12 ? 833 HOH A O 1 HETATM 4326 O O . HOH M 7 . ? -35.745 -18.249 -36.027 1.00 33.48 ? 834 HOH A O 1 HETATM 4327 O O . HOH M 7 . ? -35.825 -14.978 -33.694 1.00 37.29 ? 835 HOH A O 1 HETATM 4328 O O . HOH M 7 . ? -33.376 -5.780 -9.486 1.00 38.65 ? 836 HOH A O 1 HETATM 4329 O O . HOH M 7 . ? -22.021 -28.012 -36.235 1.00 38.74 ? 837 HOH A O 1 HETATM 4330 O O . HOH M 7 . ? -44.123 -24.347 -8.408 1.00 56.09 ? 838 HOH A O 1 HETATM 4331 O O . HOH M 7 . ? -29.863 -40.975 2.977 1.00 57.36 ? 839 HOH A O 1 HETATM 4332 O O . HOH M 7 . ? -24.809 -23.701 3.546 1.00 43.94 ? 840 HOH A O 1 HETATM 4333 O O . HOH M 7 . ? -50.551 -37.026 -15.451 1.00 39.88 ? 841 HOH A O 1 HETATM 4334 O O . HOH M 7 . ? -0.031 -19.074 -31.860 1.00 65.19 ? 842 HOH A O 1 HETATM 4335 O O . HOH M 7 . ? -48.658 -36.004 -20.023 1.00 33.19 ? 843 HOH A O 1 HETATM 4336 O O . HOH M 7 . ? -13.735 -5.584 -28.625 1.00 55.03 ? 844 HOH A O 1 HETATM 4337 O O . HOH M 7 . ? -34.806 -14.129 -7.501 1.00 39.76 ? 845 HOH A O 1 HETATM 4338 O O . HOH M 7 . ? -20.919 -22.605 -36.125 1.00 36.42 ? 846 HOH A O 1 HETATM 4339 O O . HOH M 7 . ? -8.632 1.800 -12.774 1.00 52.39 ? 847 HOH A O 1 HETATM 4340 O O . HOH M 7 . ? -41.177 -19.529 -12.381 1.00 28.30 ? 848 HOH A O 1 HETATM 4341 O O . HOH M 7 . ? -15.532 -16.308 17.903 1.00 43.40 ? 849 HOH A O 1 HETATM 4342 O O . HOH M 7 . ? -24.435 -42.630 -29.197 1.00 37.48 ? 850 HOH A O 1 HETATM 4343 O O . HOH M 7 . ? -40.136 -16.532 -18.963 1.00 24.85 ? 851 HOH A O 1 HETATM 4344 O O . HOH M 7 . ? -29.164 -10.889 -8.484 1.00 24.06 ? 852 HOH A O 1 HETATM 4345 O O . HOH M 7 . ? -22.684 -22.547 7.639 1.00 47.78 ? 853 HOH A O 1 HETATM 4346 O O . HOH M 7 . ? -22.701 -45.586 -11.095 1.00 58.78 ? 854 HOH A O 1 HETATM 4347 O O . HOH M 7 . ? -11.495 -33.351 -24.583 1.00 38.06 ? 855 HOH A O 1 HETATM 4348 O O . HOH M 7 . ? -35.622 -11.742 0.955 1.00 34.58 ? 856 HOH A O 1 HETATM 4349 O O . HOH M 7 . ? -9.906 5.514 -10.783 1.00 59.61 ? 857 HOH A O 1 HETATM 4350 O O . HOH M 7 . ? -20.086 -1.227 5.048 1.00 45.40 ? 858 HOH A O 1 HETATM 4351 O O . HOH M 7 . ? -17.946 -18.204 18.834 1.00 43.48 ? 859 HOH A O 1 HETATM 4352 O O . HOH M 7 . ? -28.835 -51.199 -20.009 1.00 50.55 ? 860 HOH A O 1 HETATM 4353 O O . HOH M 7 . ? -8.357 -1.084 -9.139 1.00 61.82 ? 861 HOH A O 1 HETATM 4354 O O . HOH M 7 . ? -25.898 -13.558 -40.280 1.00 50.31 ? 862 HOH A O 1 HETATM 4355 O O . HOH M 7 . ? -32.624 -17.127 7.090 1.00 46.89 ? 863 HOH A O 1 HETATM 4356 O O . HOH M 7 . ? -15.125 -29.805 -28.666 1.00 33.97 ? 864 HOH A O 1 HETATM 4357 O O . HOH M 7 . ? -46.722 -20.896 -20.942 1.00 45.09 ? 865 HOH A O 1 HETATM 4358 O O . HOH M 7 . ? -40.723 -13.954 -18.026 1.00 46.34 ? 866 HOH A O 1 HETATM 4359 O O . HOH M 7 . ? -39.396 -18.643 -28.274 1.00 44.86 ? 867 HOH A O 1 HETATM 4360 O O . HOH M 7 . ? -11.641 -42.465 -21.869 1.00 41.23 ? 868 HOH A O 1 HETATM 4361 O O . HOH M 7 . ? -13.652 -1.043 2.747 1.00 60.49 ? 869 HOH A O 1 HETATM 4362 O O . HOH M 7 . ? -30.087 -3.429 -15.661 1.00 44.74 ? 870 HOH A O 1 HETATM 4363 O O . HOH M 7 . ? -2.953 -12.655 14.158 1.00 36.12 ? 871 HOH A O 1 HETATM 4364 O O . HOH M 7 . ? -37.692 -16.120 -10.262 1.00 33.01 ? 872 HOH A O 1 HETATM 4365 O O . HOH M 7 . ? -50.283 -34.632 -14.577 1.00 41.46 ? 873 HOH A O 1 HETATM 4366 O O . HOH M 7 . ? -19.763 -1.483 2.201 1.00 38.61 ? 874 HOH A O 1 HETATM 4367 O O . HOH M 7 . ? -15.594 -22.519 -36.148 1.00 68.78 ? 875 HOH A O 1 HETATM 4368 O O . HOH M 7 . ? -28.825 -6.344 10.499 1.00 51.16 ? 876 HOH A O 1 HETATM 4369 O O . HOH M 7 . ? -43.920 -31.213 -33.639 1.00 53.39 ? 877 HOH A O 1 HETATM 4370 O O . HOH M 7 . ? -12.861 -1.390 -2.537 1.00 41.01 ? 878 HOH A O 1 HETATM 4371 O O . HOH M 7 . ? -16.772 -32.522 -16.146 1.00 38.14 ? 879 HOH A O 1 HETATM 4372 O O . HOH M 7 . ? -27.683 -4.920 -5.490 1.00 58.13 ? 880 HOH A O 1 HETATM 4373 O O . HOH M 7 . ? -32.044 -11.165 6.620 1.00 46.92 ? 881 HOH A O 1 HETATM 4374 O O . HOH M 7 . ? -38.371 -40.747 -8.087 1.00 35.27 ? 882 HOH A O 1 HETATM 4375 O O . HOH M 7 . ? -23.288 -7.876 -27.645 1.00 46.22 ? 883 HOH A O 1 HETATM 4376 O O . HOH M 7 . ? -2.635 -5.334 -5.999 1.00 43.02 ? 884 HOH A O 1 HETATM 4377 O O . HOH M 7 . ? -30.210 -8.963 -6.903 1.00 50.35 ? 885 HOH A O 1 HETATM 4378 O O . HOH M 7 . ? -27.158 -5.517 -19.562 1.00 58.61 ? 886 HOH A O 1 HETATM 4379 O O . HOH M 7 . ? -6.647 -11.542 15.231 1.00 55.36 ? 887 HOH A O 1 HETATM 4380 O O . HOH M 7 . ? -26.632 -8.318 -36.655 1.00 52.13 ? 888 HOH A O 1 HETATM 4381 O O . HOH M 7 . ? -52.862 -21.972 -24.855 1.00 71.62 ? 889 HOH A O 1 HETATM 4382 O O . HOH M 7 . ? 1.085 -6.438 -7.646 1.00 49.79 ? 890 HOH A O 1 HETATM 4383 O O . HOH M 7 . ? -19.439 -9.065 12.937 1.00 49.07 ? 891 HOH A O 1 HETATM 4384 O O . HOH M 7 . ? -39.641 -44.221 -1.053 1.00 63.60 ? 892 HOH A O 1 HETATM 4385 O O . HOH M 7 . ? -6.823 -30.881 -21.366 1.00 58.59 ? 893 HOH A O 1 HETATM 4386 O O . HOH M 7 . ? -0.862 -7.879 5.121 1.00 51.46 ? 894 HOH A O 1 HETATM 4387 O O . HOH M 7 . ? -30.197 -13.353 -8.074 1.00 33.78 ? 895 HOH A O 1 HETATM 4388 O O . HOH M 7 . ? 12.496 -16.083 1.967 1.00 53.49 ? 896 HOH A O 1 HETATM 4389 O O . HOH M 7 . ? -20.489 -31.362 -14.429 1.00 39.02 ? 897 HOH A O 1 HETATM 4390 O O . HOH M 7 . ? -25.591 -1.666 -13.623 1.00 44.13 ? 898 HOH A O 1 HETATM 4391 O O . HOH M 7 . ? -44.633 -39.671 -6.672 1.00 57.56 ? 899 HOH A O 1 HETATM 4392 O O . HOH M 7 . ? -6.785 -13.310 16.888 1.00 43.91 ? 900 HOH A O 1 HETATM 4393 O O . HOH M 7 . ? -35.492 -31.133 -41.702 1.00 49.86 ? 901 HOH A O 1 HETATM 4394 O O . HOH M 7 . ? -43.035 -42.478 -23.501 1.00 45.30 ? 902 HOH A O 1 HETATM 4395 O O . HOH M 7 . ? -51.827 -29.397 -14.850 1.00 45.40 ? 903 HOH A O 1 HETATM 4396 O O . HOH M 7 . ? -25.467 -4.771 -4.446 1.00 44.40 ? 904 HOH A O 1 HETATM 4397 O O . HOH M 7 . ? -19.134 -1.762 -2.657 1.00 57.25 ? 905 HOH A O 1 HETATM 4398 O O . HOH M 7 . ? -53.663 -20.575 -22.538 1.00 64.85 ? 906 HOH A O 1 HETATM 4399 O O . HOH M 7 . ? -33.405 -19.607 8.968 1.00 58.65 ? 907 HOH A O 1 HETATM 4400 O O . HOH M 7 . ? -35.424 -44.222 -17.242 1.00 49.90 ? 908 HOH A O 1 HETATM 4401 O O . HOH M 7 . ? -27.324 -2.652 -12.485 1.00 41.48 ? 909 HOH A O 1 HETATM 4402 O O . HOH M 7 . ? -21.376 -30.700 -36.987 1.00 59.89 ? 910 HOH A O 1 HETATM 4403 O O . HOH M 7 . ? -41.240 -11.667 -6.320 1.00 53.09 ? 911 HOH A O 1 HETATM 4404 O O . HOH M 7 . ? -18.128 -21.520 -39.773 1.00 53.63 ? 912 HOH A O 1 HETATM 4405 O O . HOH M 7 . ? -31.822 -11.192 -3.292 1.00 49.65 ? 913 HOH A O 1 HETATM 4406 O O . HOH M 7 . ? -46.592 -29.516 -33.548 1.00 58.58 ? 914 HOH A O 1 HETATM 4407 O O . HOH M 7 . ? -36.541 -43.619 -31.970 1.00 50.40 ? 915 HOH A O 1 HETATM 4408 O O . HOH M 7 . ? -40.582 -13.704 -13.566 1.00 43.22 ? 916 HOH A O 1 HETATM 4409 O O . HOH M 7 . ? -25.538 -9.241 -25.575 1.00 45.62 ? 917 HOH A O 1 HETATM 4410 O O . HOH M 7 . ? -22.463 -23.696 5.025 1.00 49.29 ? 918 HOH A O 1 HETATM 4411 O O . HOH M 7 . ? -24.376 -41.046 -37.102 1.00 30.00 ? 919 HOH A O 1 HETATM 4412 O O . HOH M 7 . ? -43.839 -34.193 -30.252 1.00 45.16 ? 920 HOH A O 1 HETATM 4413 O O . HOH M 7 . ? 3.100 -15.722 -31.253 1.00 44.57 ? 921 HOH A O 1 HETATM 4414 O O . HOH M 7 . ? -3.433 -5.531 6.417 1.00 56.01 ? 922 HOH A O 1 HETATM 4415 O O . HOH M 7 . ? -11.739 -40.769 -18.138 1.00 52.41 ? 923 HOH A O 1 HETATM 4416 O O . HOH M 7 . ? -35.065 -17.974 11.226 1.00 57.14 ? 924 HOH A O 1 HETATM 4417 O O . HOH M 7 . ? 7.698 -18.932 -2.989 1.00 55.14 ? 925 HOH A O 1 HETATM 4418 O O . HOH M 7 . ? -26.832 -47.023 -30.371 1.00 60.65 ? 926 HOH A O 1 HETATM 4419 O O . HOH M 7 . ? -49.015 -29.192 -29.025 1.00 56.14 ? 927 HOH A O 1 HETATM 4420 O O . HOH M 7 . ? -42.059 -43.254 3.530 1.00 58.24 ? 928 HOH A O 1 HETATM 4421 O O . HOH M 7 . ? -43.247 -21.278 -11.670 1.00 32.51 ? 929 HOH A O 1 HETATM 4422 O O . HOH M 7 . ? -32.171 -43.996 -32.486 1.00 49.43 ? 930 HOH A O 1 HETATM 4423 O O . HOH M 7 . ? -7.588 -39.030 -26.600 1.00 62.05 ? 931 HOH A O 1 HETATM 4424 O O . HOH M 7 . ? 6.007 -6.613 -7.852 1.00 60.59 ? 932 HOH A O 1 HETATM 4425 O O . HOH M 7 . ? -33.874 -11.537 -33.195 1.00 47.91 ? 933 HOH A O 1 HETATM 4426 O O . HOH M 7 . ? -3.126 -20.062 -23.820 1.00 47.36 ? 934 HOH A O 1 HETATM 4427 O O . HOH M 7 . ? -11.919 2.713 -4.035 1.00 59.82 ? 935 HOH A O 1 HETATM 4428 O O . HOH M 7 . ? -51.687 -20.741 -11.577 1.00 57.17 ? 936 HOH A O 1 HETATM 4429 O O . HOH M 7 . ? -22.767 -21.751 -38.198 1.00 49.84 ? 937 HOH A O 1 HETATM 4430 O O . HOH M 7 . ? -39.704 -11.843 1.576 1.00 49.15 ? 938 HOH A O 1 HETATM 4431 O O . HOH M 7 . ? -39.215 -9.100 -12.593 1.00 59.73 ? 939 HOH A O 1 HETATM 4432 O O . HOH M 7 . ? -51.765 -23.976 -16.121 1.00 63.78 ? 940 HOH A O 1 HETATM 4433 O O . HOH M 7 . ? -46.734 -42.276 -14.643 1.00 34.27 ? 941 HOH A O 1 HETATM 4434 O O . HOH M 7 . ? -21.876 -20.926 16.370 1.00 53.33 ? 942 HOH A O 1 HETATM 4435 O O . HOH M 7 . ? -7.245 -4.611 -29.187 1.00 61.44 ? 943 HOH A O 1 HETATM 4436 O O . HOH M 7 . ? -25.820 -6.901 -23.495 1.00 66.34 ? 944 HOH A O 1 HETATM 4437 O O . HOH M 7 . ? -39.299 -44.256 -16.291 1.00 45.91 ? 945 HOH A O 1 HETATM 4438 O O . HOH M 7 . ? -57.270 -27.075 -21.116 1.00 50.29 ? 946 HOH A O 1 HETATM 4439 O O . HOH M 7 . ? -43.389 -35.387 -28.079 1.00 37.63 ? 947 HOH A O 1 HETATM 4440 O O . HOH M 7 . ? -3.067 -0.000 -0.000 0.50 54.15 ? 948 HOH A O 1 HETATM 4441 O O . HOH M 7 . ? 1.240 -14.834 13.568 1.00 63.90 ? 949 HOH A O 1 HETATM 4442 O O . HOH M 7 . ? -43.994 -16.620 -2.587 1.00 47.64 ? 950 HOH A O 1 HETATM 4443 O O . HOH M 7 . ? -44.897 -16.879 -21.314 1.00 59.76 ? 951 HOH A O 1 HETATM 4444 O O . HOH M 7 . ? -18.905 -13.944 12.893 1.00 35.90 ? 952 HOH A O 1 HETATM 4445 O O . HOH M 7 . ? -9.233 -3.922 -3.539 1.00 45.94 ? 953 HOH A O 1 HETATM 4446 O O . HOH M 7 . ? -19.334 1.001 -15.563 1.00 48.85 ? 954 HOH A O 1 HETATM 4447 O O . HOH M 7 . ? -27.282 -40.426 -7.223 1.00 50.35 ? 955 HOH A O 1 HETATM 4448 O O . HOH M 7 . ? -4.598 -6.879 8.773 1.00 60.91 ? 956 HOH A O 1 HETATM 4449 O O . HOH M 7 . ? -40.253 -15.298 -11.642 1.00 37.92 ? 957 HOH A O 1 HETATM 4450 O O . HOH M 7 . ? -7.563 -6.290 12.004 1.00 49.85 ? 958 HOH A O 1 HETATM 4451 O O . HOH M 7 . ? -32.406 -18.803 -39.317 1.00 48.81 ? 959 HOH A O 1 HETATM 4452 O O . HOH M 7 . ? -35.053 -10.655 -31.065 1.00 46.37 ? 960 HOH A O 1 HETATM 4453 O O . HOH M 7 . ? 8.021 -20.140 6.082 1.00 47.89 ? 961 HOH A O 1 HETATM 4454 O O . HOH M 7 . ? -29.801 -7.965 -4.105 1.00 57.09 ? 962 HOH A O 1 HETATM 4455 O O . HOH M 7 . ? -47.370 -36.167 -26.410 1.00 37.88 ? 963 HOH A O 1 HETATM 4456 O O . HOH M 7 . ? -41.344 -19.003 -32.988 1.00 62.67 ? 964 HOH A O 1 HETATM 4457 O O . HOH M 7 . ? -49.518 -30.426 -2.283 1.00 33.02 ? 965 HOH A O 1 HETATM 4458 O O . HOH M 7 . ? -51.210 -27.107 -3.995 1.00 48.12 ? 966 HOH A O 1 HETATM 4459 O O . HOH M 7 . ? -42.063 -17.141 -11.411 1.00 34.59 ? 967 HOH A O 1 HETATM 4460 O O . HOH M 7 . ? -13.620 -30.599 -30.664 1.00 46.07 ? 968 HOH A O 1 HETATM 4461 O O . HOH M 7 . ? -42.944 -13.132 -16.162 1.00 48.02 ? 969 HOH A O 1 HETATM 4462 O O . HOH M 7 . ? -49.412 -40.957 -20.715 1.00 56.96 ? 970 HOH A O 1 HETATM 4463 O O . HOH M 7 . ? -15.898 -32.259 -26.432 1.00 47.83 ? 971 HOH A O 1 HETATM 4464 O O . HOH M 7 . ? -43.103 -15.378 -22.209 1.00 55.24 ? 972 HOH A O 1 HETATM 4465 O O . HOH M 7 . ? -40.614 -13.393 2.737 1.00 44.22 ? 973 HOH A O 1 HETATM 4466 O O . HOH M 7 . ? -49.108 -37.646 -18.179 1.00 47.30 ? 974 HOH A O 1 HETATM 4467 O O . HOH M 7 . ? -44.603 -17.240 -0.662 1.00 49.56 ? 975 HOH A O 1 HETATM 4468 O O . HOH M 7 . ? -45.577 -20.112 -29.394 1.00 52.71 ? 976 HOH A O 1 HETATM 4469 O O . HOH M 7 . ? -49.997 -37.224 -21.837 1.00 45.72 ? 977 HOH A O 1 HETATM 4470 O O . HOH M 7 . ? -16.006 -10.593 18.504 1.00 54.45 ? 978 HOH A O 1 HETATM 4471 O O . HOH M 7 . ? -29.430 -21.295 -39.550 1.00 44.94 ? 979 HOH A O 1 HETATM 4472 O O . HOH M 7 . ? -47.011 -20.013 -10.177 1.00 54.24 ? 980 HOH A O 1 HETATM 4473 O O . HOH M 7 . ? -46.084 -43.442 -18.564 1.00 48.59 ? 981 HOH A O 1 HETATM 4474 O O . HOH M 7 . ? -32.372 -10.613 -6.455 1.00 53.00 ? 982 HOH A O 1 HETATM 4475 O O . HOH M 7 . ? -15.745 -55.600 -21.911 1.00 58.43 ? 983 HOH A O 1 HETATM 4476 O O . HOH M 7 . ? -37.659 -15.876 -31.481 1.00 60.41 ? 984 HOH A O 1 HETATM 4477 O O . HOH M 7 . ? -17.294 -31.875 -33.146 1.00 49.68 ? 985 HOH A O 1 HETATM 4478 O O . HOH M 7 . ? -28.784 -15.998 -39.259 1.00 46.01 ? 986 HOH A O 1 HETATM 4479 O O . HOH M 7 . ? -50.391 -31.796 -21.037 1.00 45.56 ? 987 HOH A O 1 HETATM 4480 O O . HOH M 7 . ? -21.694 -42.610 -35.178 1.00 53.27 ? 988 HOH A O 1 HETATM 4481 O O . HOH M 7 . ? -48.425 -40.062 -17.978 1.00 51.59 ? 989 HOH A O 1 HETATM 4482 O O . HOH M 7 . ? -15.536 -32.628 -31.302 1.00 58.80 ? 990 HOH A O 1 HETATM 4483 O O . HOH M 7 . ? -20.845 -25.495 -36.890 1.00 43.63 ? 991 HOH A O 1 HETATM 4484 O O . HOH M 7 . ? -39.131 -18.230 -32.241 1.00 49.17 ? 992 HOH A O 1 HETATM 4485 O O . HOH M 7 . ? -9.690 -38.288 -17.612 1.00 46.81 ? 993 HOH A O 1 HETATM 4486 O O . HOH M 7 . ? -52.657 -31.462 -16.739 1.00 47.49 ? 994 HOH A O 1 HETATM 4487 O O . HOH M 7 . ? -49.750 -33.665 -19.197 1.00 38.42 ? 995 HOH A O 1 HETATM 4488 O O . HOH M 7 . ? -0.821 -3.244 -4.999 1.00 56.48 ? 996 HOH A O 1 HETATM 4489 O O . HOH M 7 . ? -43.484 -43.843 -20.016 1.00 59.32 ? 997 HOH A O 1 HETATM 4490 O O . HOH M 7 . ? -34.923 -18.308 -38.942 1.00 54.45 ? 998 HOH A O 1 HETATM 4491 O O . HOH M 7 . ? -13.681 -16.639 20.321 1.00 55.83 ? 999 HOH A O 1 HETATM 4492 O O . HOH M 7 . ? -9.749 -40.141 -15.885 1.00 50.94 ? 1000 HOH A O 1 HETATM 4493 O O . HOH N 7 . ? -37.587 -34.733 5.141 1.00 50.56 ? 1201 HOH B O 1 HETATM 4494 O O . HOH N 7 . ? -20.332 -29.822 -4.173 1.00 49.12 ? 1202 HOH B O 1 HETATM 4495 O O . HOH N 7 . ? 0.108 -18.989 -6.203 1.00 31.65 ? 1203 HOH B O 1 HETATM 4496 O O . HOH N 7 . ? -27.188 -27.390 6.270 1.00 46.24 ? 1204 HOH B O 1 HETATM 4497 O O . HOH N 7 . ? 1.943 -21.964 -7.043 1.00 43.43 ? 1205 HOH B O 1 HETATM 4498 O O . HOH N 7 . ? -5.213 -30.288 -16.169 1.00 45.83 ? 1206 HOH B O 1 HETATM 4499 O O . HOH N 7 . ? -23.679 -26.385 -4.555 1.00 40.15 ? 1207 HOH B O 1 HETATM 4500 O O . HOH N 7 . ? -36.856 -42.577 -18.873 1.00 33.51 ? 1208 HOH B O 1 HETATM 4501 O O . HOH N 7 . ? -24.827 -38.878 -9.715 1.00 42.78 ? 1209 HOH B O 1 HETATM 4502 O O . HOH N 7 . ? 1.404 -30.721 -4.201 1.00 46.46 ? 1210 HOH B O 1 HETATM 4503 O O . HOH N 7 . ? -3.036 -32.828 9.798 1.00 46.19 ? 1211 HOH B O 1 HETATM 4504 O O . HOH N 7 . ? -20.604 -25.115 4.083 1.00 32.77 ? 1212 HOH B O 1 HETATM 4505 O O . HOH N 7 . ? -5.274 -7.590 -17.680 1.00 38.02 ? 1213 HOH B O 1 HETATM 4506 O O . HOH N 7 . ? -7.044 -21.674 -10.466 1.00 24.61 ? 1214 HOH B O 1 HETATM 4507 O O . HOH N 7 . ? -30.099 -37.704 -24.868 1.00 22.38 ? 1215 HOH B O 1 HETATM 4508 O O . HOH N 7 . ? -2.302 -5.703 -20.742 1.00 46.24 ? 1216 HOH B O 1 HETATM 4509 O O . HOH N 7 . ? -33.086 -42.838 -17.771 1.00 33.00 ? 1217 HOH B O 1 HETATM 4510 O O . HOH N 7 . ? -45.596 -21.436 -2.930 1.00 44.82 ? 1218 HOH B O 1 HETATM 4511 O O . HOH N 7 . ? -42.517 -19.740 -7.804 1.00 49.32 ? 1219 HOH B O 1 HETATM 4512 O O . HOH N 7 . ? -16.487 -3.707 -22.322 1.00 26.83 ? 1220 HOH B O 1 HETATM 4513 O O . HOH N 7 . ? -30.463 -31.721 -19.950 1.00 19.25 ? 1221 HOH B O 1 HETATM 4514 O O . HOH N 7 . ? -14.446 -28.129 3.811 1.00 29.70 ? 1222 HOH B O 1 HETATM 4515 O O . HOH N 7 . ? -0.532 -31.214 -0.148 1.00 44.91 ? 1223 HOH B O 1 HETATM 4516 O O . HOH N 7 . ? -8.585 -33.669 -15.858 1.00 36.48 ? 1224 HOH B O 1 HETATM 4517 O O . HOH N 7 . ? -39.491 -35.264 -22.849 1.00 25.37 ? 1225 HOH B O 1 HETATM 4518 O O . HOH N 7 . ? -13.354 -32.707 -22.628 1.00 46.92 ? 1226 HOH B O 1 HETATM 4519 O O . HOH N 7 . ? -28.765 -26.910 -17.543 1.00 18.34 ? 1227 HOH B O 1 HETATM 4520 O O . HOH N 7 . ? -5.254 -25.919 -21.783 1.00 51.98 ? 1228 HOH B O 1 HETATM 4521 O O . HOH N 7 . ? -21.330 -20.798 -2.113 1.00 37.57 ? 1229 HOH B O 1 HETATM 4522 O O . HOH N 7 . ? 6.814 -21.370 -1.959 1.00 39.22 ? 1230 HOH B O 1 HETATM 4523 O O . HOH N 7 . ? -20.606 -20.045 -11.634 1.00 22.88 ? 1231 HOH B O 1 HETATM 4524 O O . HOH N 7 . ? -28.887 -26.535 2.001 1.00 38.01 ? 1232 HOH B O 1 HETATM 4525 O O . HOH N 7 . ? -11.549 -0.881 -17.439 1.00 39.14 ? 1233 HOH B O 1 HETATM 4526 O O . HOH N 7 . ? -12.397 -29.244 -26.038 1.00 28.77 ? 1234 HOH B O 1 HETATM 4527 O O . HOH N 7 . ? -7.233 -22.259 -22.382 1.00 27.51 ? 1235 HOH B O 1 HETATM 4528 O O . HOH N 7 . ? -23.829 -31.966 -13.766 1.00 37.57 ? 1236 HOH B O 1 HETATM 4529 O O . HOH N 7 . ? 3.715 -17.277 -7.650 1.00 43.71 ? 1237 HOH B O 1 HETATM 4530 O O . HOH N 7 . ? -27.573 -24.381 3.610 1.00 44.13 ? 1238 HOH B O 1 HETATM 4531 O O . HOH N 7 . ? -13.868 -34.975 -10.682 1.00 54.49 ? 1239 HOH B O 1 HETATM 4532 O O . HOH N 7 . ? -12.592 -26.449 -19.846 1.00 29.51 ? 1240 HOH B O 1 HETATM 4533 O O . HOH N 7 . ? -2.529 -29.676 10.936 1.00 48.66 ? 1241 HOH B O 1 HETATM 4534 O O . HOH N 7 . ? -9.098 -9.180 -12.638 1.00 45.94 ? 1242 HOH B O 1 HETATM 4535 O O . HOH N 7 . ? -6.570 -7.839 -14.780 1.00 40.05 ? 1243 HOH B O 1 HETATM 4536 O O . HOH N 7 . ? -17.942 -28.321 -15.859 1.00 33.83 ? 1244 HOH B O 1 HETATM 4537 O O . HOH N 7 . ? -7.593 -11.662 -33.113 1.00 53.84 ? 1245 HOH B O 1 HETATM 4538 O O . HOH N 7 . ? -8.145 -28.792 10.610 1.00 45.92 ? 1246 HOH B O 1 HETATM 4539 O O . HOH N 7 . ? -33.798 -21.772 -1.195 1.00 25.98 ? 1247 HOH B O 1 HETATM 4540 O O . HOH N 7 . ? -18.794 -24.137 -20.994 1.00 30.88 ? 1248 HOH B O 1 HETATM 4541 O O . HOH N 7 . ? -11.625 -23.711 -4.775 1.00 23.61 ? 1249 HOH B O 1 HETATM 4542 O O . HOH N 7 . ? -2.226 -32.549 1.985 1.00 48.87 ? 1250 HOH B O 1 HETATM 4543 O O . HOH N 7 . ? -7.724 -27.441 -21.980 1.00 47.81 ? 1251 HOH B O 1 HETATM 4544 O O . HOH N 7 . ? -15.279 -36.216 -14.022 1.00 46.89 ? 1252 HOH B O 1 HETATM 4545 O O . HOH N 7 . ? 5.546 -28.470 -4.378 1.00 36.88 ? 1253 HOH B O 1 HETATM 4546 O O . HOH N 7 . ? -28.600 -29.574 4.566 1.00 54.67 ? 1254 HOH B O 1 HETATM 4547 O O . HOH N 7 . ? -32.182 -44.158 -14.447 1.00 52.06 ? 1255 HOH B O 1 HETATM 4548 O O . HOH N 7 . ? -4.400 -12.325 -19.045 1.00 32.28 ? 1256 HOH B O 1 HETATM 4549 O O . HOH N 7 . ? 5.835 -23.292 4.334 1.00 37.34 ? 1257 HOH B O 1 HETATM 4550 O O . HOH N 7 . ? 0.496 -23.488 -5.374 1.00 37.37 ? 1258 HOH B O 1 HETATM 4551 O O . HOH N 7 . ? -6.074 -32.654 -7.370 1.00 37.80 ? 1259 HOH B O 1 HETATM 4552 O O . HOH N 7 . ? 1.148 -14.970 -15.390 1.00 37.48 ? 1260 HOH B O 1 HETATM 4553 O O . HOH N 7 . ? -3.983 -29.487 -11.234 1.00 45.39 ? 1261 HOH B O 1 HETATM 4554 O O . HOH N 7 . ? -38.687 -42.979 -28.734 1.00 59.25 ? 1262 HOH B O 1 HETATM 4555 O O . HOH N 7 . ? -6.276 -37.950 -2.762 1.00 58.16 ? 1263 HOH B O 1 HETATM 4556 O O . HOH N 7 . ? -14.613 -30.380 -8.608 1.00 45.16 ? 1264 HOH B O 1 HETATM 4557 O O . HOH N 7 . ? -10.525 0.161 -14.100 1.00 38.71 ? 1265 HOH B O 1 HETATM 4558 O O . HOH N 7 . ? -12.214 -34.150 -16.740 1.00 37.92 ? 1266 HOH B O 1 HETATM 4559 O O . HOH N 7 . ? -18.711 -9.807 -31.689 1.00 29.49 ? 1267 HOH B O 1 HETATM 4560 O O . HOH N 7 . ? -21.991 -31.774 -6.478 1.00 41.48 ? 1268 HOH B O 1 HETATM 4561 O O . HOH N 7 . ? -14.704 -2.610 -24.412 1.00 46.71 ? 1269 HOH B O 1 HETATM 4562 O O . HOH N 7 . ? -1.348 -6.826 -8.411 1.00 54.88 ? 1270 HOH B O 1 HETATM 4563 O O . HOH N 7 . ? -34.158 -43.436 -27.068 1.00 39.22 ? 1271 HOH B O 1 HETATM 4564 O O . HOH N 7 . ? -7.229 -2.181 -22.381 1.00 59.59 ? 1272 HOH B O 1 HETATM 4565 O O . HOH N 7 . ? -31.246 -32.738 -22.261 1.00 26.29 ? 1273 HOH B O 1 HETATM 4566 O O . HOH N 7 . ? -8.631 -31.708 14.810 1.00 58.37 ? 1274 HOH B O 1 HETATM 4567 O O . HOH N 7 . ? -8.378 -27.655 7.773 1.00 45.83 ? 1275 HOH B O 1 HETATM 4568 O O . HOH N 7 . ? 4.313 -20.622 7.024 1.00 34.88 ? 1276 HOH B O 1 HETATM 4569 O O . HOH N 7 . ? -8.343 -4.320 -5.988 1.00 41.56 ? 1277 HOH B O 1 HETATM 4570 O O . HOH N 7 . ? -4.974 -16.388 -23.128 1.00 45.16 ? 1278 HOH B O 1 HETATM 4571 O O . HOH N 7 . ? 2.009 -16.054 10.661 1.00 43.74 ? 1279 HOH B O 1 HETATM 4572 O O . HOH N 7 . ? -8.572 -6.198 -17.121 1.00 47.02 ? 1280 HOH B O 1 HETATM 4573 O O . HOH N 7 . ? -17.507 -31.185 -6.287 1.00 56.02 ? 1281 HOH B O 1 HETATM 4574 O O . HOH N 7 . ? -33.095 -32.360 -0.855 1.00 34.78 ? 1282 HOH B O 1 HETATM 4575 O O . HOH N 7 . ? -12.631 -27.942 18.668 1.00 47.07 ? 1283 HOH B O 1 HETATM 4576 O O . HOH N 7 . ? -4.737 -36.590 1.403 1.00 40.41 ? 1284 HOH B O 1 HETATM 4577 O O . HOH N 7 . ? -16.403 6.853 -15.999 1.00 38.16 ? 1285 HOH B O 1 HETATM 4578 O O . HOH N 7 . ? -22.009 -36.154 -9.663 1.00 33.96 ? 1286 HOH B O 1 HETATM 4579 O O . HOH N 7 . ? -20.936 -37.739 6.666 1.00 60.83 ? 1287 HOH B O 1 HETATM 4580 O O . HOH N 7 . ? -0.977 -31.758 -2.899 1.00 40.23 ? 1288 HOH B O 1 HETATM 4581 O O . HOH N 7 . ? -26.207 -25.547 -2.962 1.00 47.47 ? 1289 HOH B O 1 HETATM 4582 O O . HOH N 7 . ? 3.972 -28.419 -6.360 1.00 43.35 ? 1290 HOH B O 1 HETATM 4583 O O . HOH N 7 . ? 6.266 -35.079 -1.573 1.00 44.32 ? 1291 HOH B O 1 HETATM 4584 O O . HOH N 7 . ? -8.627 -6.760 -14.051 1.00 44.52 ? 1292 HOH B O 1 HETATM 4585 O O . HOH N 7 . ? -19.196 -31.923 -9.884 1.00 50.67 ? 1293 HOH B O 1 HETATM 4586 O O . HOH N 7 . ? 5.168 -23.312 7.536 1.00 45.85 ? 1294 HOH B O 1 HETATM 4587 O O . HOH N 7 . ? -23.861 -36.481 1.259 1.00 59.90 ? 1295 HOH B O 1 HETATM 4588 O O . HOH N 7 . ? -3.987 -10.181 -17.238 1.00 40.37 ? 1296 HOH B O 1 HETATM 4589 O O . HOH N 7 . ? -38.401 -19.566 -11.155 1.00 33.11 ? 1297 HOH B O 1 HETATM 4590 O O . HOH N 7 . ? -7.154 -3.643 -18.245 1.00 49.29 ? 1298 HOH B O 1 HETATM 4591 O O . HOH N 7 . ? 4.350 -17.805 10.999 1.00 58.97 ? 1299 HOH B O 1 HETATM 4592 O O . HOH N 7 . ? 1.816 -32.760 -0.051 1.00 44.08 ? 1300 HOH B O 1 HETATM 4593 O O . HOH N 7 . ? -4.023 -27.926 -13.294 1.00 54.63 ? 1301 HOH B O 1 HETATM 4594 O O . HOH N 7 . ? -14.910 -32.975 9.634 1.00 58.70 ? 1302 HOH B O 1 HETATM 4595 O O . HOH N 7 . ? -2.612 -35.146 2.786 1.00 48.13 ? 1303 HOH B O 1 HETATM 4596 O O . HOH N 7 . ? -46.120 -23.225 -6.719 1.00 47.14 ? 1304 HOH B O 1 HETATM 4597 O O . HOH N 7 . ? -27.036 -42.300 -9.342 1.00 49.86 ? 1305 HOH B O 1 HETATM 4598 O O . HOH N 7 . ? -6.942 -24.094 -24.203 1.00 46.08 ? 1306 HOH B O 1 HETATM 4599 O O . HOH N 7 . ? -23.158 -2.793 -31.477 1.00 55.57 ? 1307 HOH B O 1 HETATM 4600 O O . HOH N 7 . ? -8.714 -32.375 -23.658 1.00 56.78 ? 1308 HOH B O 1 HETATM 4601 O O . HOH N 7 . ? -2.990 -37.737 -4.809 1.00 60.33 ? 1309 HOH B O 1 HETATM 4602 O O . HOH N 7 . ? -6.828 -3.036 -15.948 1.00 53.80 ? 1310 HOH B O 1 HETATM 4603 O O . HOH N 7 . ? -5.820 -3.029 -20.083 1.00 49.58 ? 1311 HOH B O 1 HETATM 4604 O O . HOH N 7 . ? -15.093 -30.029 1.701 1.00 38.37 ? 1312 HOH B O 1 HETATM 4605 O O . HOH N 7 . ? -38.896 -18.001 -9.069 1.00 33.52 ? 1313 HOH B O 1 HETATM 4606 O O . HOH N 7 . ? -10.265 -35.854 -16.154 1.00 46.73 ? 1314 HOH B O 1 HETATM 4607 O O . HOH N 7 . ? -28.235 -36.269 -22.744 1.00 60.74 ? 1315 HOH B O 1 HETATM 4608 O O . HOH N 7 . ? -9.317 -4.117 -25.478 1.00 51.79 ? 1316 HOH B O 1 HETATM 4609 O O . HOH N 7 . ? 4.494 -35.789 0.551 1.00 43.48 ? 1317 HOH B O 1 HETATM 4610 O O . HOH N 7 . ? -24.778 -27.050 5.604 1.00 55.57 ? 1318 HOH B O 1 HETATM 4611 O O . HOH N 7 . ? -40.846 -35.088 -27.350 1.00 28.85 ? 1319 HOH B O 1 HETATM 4612 O O . HOH N 7 . ? -17.495 -30.551 -13.944 1.00 27.69 ? 1320 HOH B O 1 HETATM 4613 O O . HOH N 7 . ? -2.801 -12.696 -21.057 1.00 46.33 ? 1321 HOH B O 1 HETATM 4614 O O . HOH N 7 . ? 1.677 -35.788 -3.105 1.00 58.34 ? 1322 HOH B O 1 HETATM 4615 O O . HOH N 7 . ? -44.542 -21.399 -8.959 1.00 48.93 ? 1323 HOH B O 1 HETATM 4616 O O . HOH N 7 . ? -38.572 -44.371 -19.937 1.00 50.57 ? 1324 HOH B O 1 HETATM 4617 O O . HOH N 7 . ? -41.625 -17.202 -8.898 1.00 47.27 ? 1325 HOH B O 1 HETATM 4618 O O . HOH N 7 . ? 1.475 -35.515 -0.068 1.00 41.01 ? 1326 HOH B O 1 HETATM 4619 O O . HOH N 7 . ? -10.845 -36.630 -13.732 1.00 45.09 ? 1327 HOH B O 1 HETATM 4620 O O . HOH N 7 . ? -41.534 -44.347 -25.082 1.00 55.17 ? 1328 HOH B O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 SER 1 28 ? ? ? A . n A 1 2 ALA 2 29 ? ? ? A . n A 1 3 SER 3 30 ? ? ? A . n A 1 4 LYS 4 31 ? ? ? A . n A 1 5 GLU 5 32 ? ? ? A . n A 1 6 PRO 6 33 ? ? ? A . n A 1 7 ASP 7 34 34 ASP ASP A . n A 1 8 ASN 8 35 35 ASN ASN A . n A 1 9 HIS 9 36 36 HIS HIS A . n A 1 10 VAL 10 37 37 VAL VAL A . n A 1 11 TYR 11 38 38 TYR TYR A . n A 1 12 THR 12 39 39 THR THR A . n A 1 13 ARG 13 40 40 ARG ARG A . n A 1 14 ALA 14 41 41 ALA ALA A . n A 1 15 ALA 15 42 42 ALA ALA A . n A 1 16 VAL 16 43 43 VAL VAL A . n A 1 17 ALA 17 44 44 ALA ALA A . n A 1 18 ALA 18 45 45 ALA ALA A . n A 1 19 ASP 19 46 46 ASP ASP A . n A 1 20 ALA 20 47 47 ALA ALA A . n A 1 21 LYS 21 48 48 LYS LYS A . n A 1 22 GLN 22 49 49 GLN GLN A . n A 1 23 CYS 23 50 50 CYS CYS A . n A 1 24 SER 24 51 51 SER SER A . n A 1 25 LYS 25 52 52 LYS LYS A . n A 1 26 ILE 26 53 53 ILE ILE A . n A 1 27 GLY 27 54 54 GLY GLY A . n A 1 28 ARG 28 55 55 ARG ARG A . n A 1 29 ASP 29 56 56 ASP ASP A . n A 1 30 ALA 30 57 57 ALA ALA A . n A 1 31 LEU 31 58 58 LEU LEU A . n A 1 32 ARG 32 59 59 ARG ARG A . n A 1 33 ASP 33 60 60 ASP ASP A . n A 1 34 GLY 34 61 61 GLY GLY A . n A 1 35 GLY 35 62 62 GLY GLY A . n A 1 36 SER 36 63 63 SER SER A . n A 1 37 ALA 37 64 64 ALA ALA A . n A 1 38 VAL 38 65 65 VAL VAL A . n A 1 39 ASP 39 66 66 ASP ASP A . n A 1 40 ALA 40 67 67 ALA ALA A . n A 1 41 ALA 41 68 68 ALA ALA A . n A 1 42 ILE 42 69 69 ILE ILE A . n A 1 43 ALA 43 70 70 ALA ALA A . n A 1 44 ALA 44 71 71 ALA ALA A . n A 1 45 LEU 45 72 72 LEU LEU A . n A 1 46 LEU 46 73 73 LEU LEU A . n A 1 47 CYS 47 74 74 CYS CYS A . n A 1 48 VAL 48 75 75 VAL VAL A . n A 1 49 GLY 49 76 76 GLY GLY A . n A 1 50 LEU 50 77 77 LEU LEU A . n A 1 51 MET 51 78 78 MET MET A . n A 1 52 ASN 52 79 79 ASN ASN A . n A 1 53 ALA 53 80 80 ALA ALA A . n A 1 54 HIS 54 81 81 HIS HIS A . n A 1 55 SER 55 82 82 SER SER A . n A 1 56 MET 56 83 83 MET MET A . n A 1 57 GLY 57 84 84 GLY GLY A . n A 1 58 ILE 58 85 85 ILE ILE A . n A 1 59 GLY 59 86 86 GLY GLY A . n A 1 60 GLY 60 87 87 GLY GLY A . n A 1 61 GLY 61 88 88 GLY GLY A . n A 1 62 LEU 62 89 89 LEU LEU A . n A 1 63 PHE 63 90 90 PHE PHE A . n A 1 64 LEU 64 91 91 LEU LEU A . n A 1 65 THR 65 92 92 THR THR A . n A 1 66 ILE 66 93 93 ILE ILE A . n A 1 67 TYR 67 94 94 TYR TYR A . n A 1 68 ASN 68 95 95 ASN ASN A . n A 1 69 SER 69 96 96 SER SER A . n A 1 70 THR 70 97 97 THR THR A . n A 1 71 THR 71 98 98 THR THR A . n A 1 72 ARG 72 99 99 ARG ARG A . n A 1 73 LYS 73 100 100 LYS LYS A . n A 1 74 ALA 74 101 101 ALA ALA A . n A 1 75 GLU 75 102 102 GLU GLU A . n A 1 76 VAL 76 103 103 VAL VAL A . n A 1 77 ILE 77 104 104 ILE ILE A . n A 1 78 ASN 78 105 105 ASN ASN A . n A 1 79 ALA 79 106 106 ALA ALA A . n A 1 80 ARG 80 107 107 ARG ARG A . n A 1 81 GLU 81 108 108 GLU GLU A . n A 1 82 VAL 82 109 109 VAL VAL A . n A 1 83 ALA 83 110 110 ALA ALA A . n A 1 84 PRO 84 111 111 PRO PRO A . n A 1 85 ARG 85 112 112 ARG ARG A . n A 1 86 LEU 86 113 113 LEU LEU A . n A 1 87 ALA 87 114 114 ALA ALA A . n A 1 88 PHE 88 115 115 PHE PHE A . n A 1 89 ALA 89 116 116 ALA ALA A . n A 1 90 THR 90 117 117 THR THR A . n A 1 91 MET 91 118 118 MET MET A . n A 1 92 PHE 92 119 119 PHE PHE A . n A 1 93 ASN 93 120 120 ASN ASN A . n A 1 94 SER 94 121 121 SER SER A . n A 1 95 SER 95 122 122 SER SER A . n A 1 96 GLU 96 123 123 GLU GLU A . n A 1 97 GLN 97 124 124 GLN GLN A . n A 1 98 SER 98 125 125 SER SER A . n A 1 99 GLN 99 126 126 GLN GLN A . n A 1 100 LYS 100 127 127 LYS LYS A . n A 1 101 GLY 101 128 128 GLY GLY A . n A 1 102 GLY 102 129 129 GLY GLY A . n A 1 103 LEU 103 130 130 LEU LEU A . n A 1 104 SER 104 131 131 SER SER A . n A 1 105 VAL 105 132 132 VAL VAL A . n A 1 106 ALA 106 133 133 ALA ALA A . n A 1 107 VAL 107 134 134 VAL VAL A . n A 1 108 PRO 108 135 135 PRO PRO A . n A 1 109 GLY 109 136 136 GLY GLY A . n A 1 110 GLU 110 137 137 GLU GLU A . n A 1 111 ILE 111 138 138 ILE ILE A . n A 1 112 ARG 112 139 139 ARG ARG A . n A 1 113 GLY 113 140 140 GLY GLY A . n A 1 114 TYR 114 141 141 TYR TYR A . n A 1 115 GLU 115 142 142 GLU GLU A . n A 1 116 LEU 116 143 143 LEU LEU A . n A 1 117 ALA 117 144 144 ALA ALA A . n A 1 118 HIS 118 145 145 HIS HIS A . n A 1 119 GLN 119 146 146 GLN GLN A . n A 1 120 ARG 120 147 147 ARG ARG A . n A 1 121 HIS 121 148 148 HIS HIS A . n A 1 122 GLY 122 149 149 GLY GLY A . n A 1 123 ARG 123 150 150 ARG ARG A . n A 1 124 LEU 124 151 151 LEU LEU A . n A 1 125 PRO 125 152 152 PRO PRO A . n A 1 126 TRP 126 153 153 TRP TRP A . n A 1 127 ALA 127 154 154 ALA ALA A . n A 1 128 ARG 128 155 155 ARG ARG A . n A 1 129 LEU 129 156 156 LEU LEU A . n A 1 130 PHE 130 157 157 PHE PHE A . n A 1 131 GLN 131 158 158 GLN GLN A . n A 1 132 PRO 132 159 159 PRO PRO A . n A 1 133 SER 133 160 160 SER SER A . n A 1 134 ILE 134 161 161 ILE ILE A . n A 1 135 GLN 135 162 162 GLN GLN A . n A 1 136 LEU 136 163 163 LEU LEU A . n A 1 137 ALA 137 164 164 ALA ALA A . n A 1 138 ARG 138 165 165 ARG ARG A . n A 1 139 GLN 139 166 166 GLN GLN A . n A 1 140 GLY 140 167 167 GLY GLY A . n A 1 141 PHE 141 168 168 PHE PHE A . n A 1 142 PRO 142 169 169 PRO PRO A . n A 1 143 VAL 143 170 170 VAL VAL A . n A 1 144 GLY 144 171 171 GLY GLY A . n A 1 145 LYS 145 172 172 LYS LYS A . n A 1 146 GLY 146 173 173 GLY GLY A . n A 1 147 LEU 147 174 174 LEU LEU A . n A 1 148 ALA 148 175 175 ALA ALA A . n A 1 149 ALA 149 176 176 ALA ALA A . n A 1 150 ALA 150 177 177 ALA ALA A . n A 1 151 LEU 151 178 178 LEU LEU A . n A 1 152 GLU 152 179 179 GLU GLU A . n A 1 153 ASN 153 180 180 ASN ASN A . n A 1 154 LYS 154 181 181 LYS LYS A . n A 1 155 ARG 155 182 182 ARG ARG A . n A 1 156 THR 156 183 183 THR THR A . n A 1 157 VAL 157 184 184 VAL VAL A . n A 1 158 ILE 158 185 185 ILE ILE A . n A 1 159 GLU 159 186 186 GLU GLU A . n A 1 160 GLN 160 187 187 GLN GLN A . n A 1 161 GLN 161 188 188 GLN GLN A . n A 1 162 PRO 162 189 189 PRO PRO A . n A 1 163 VAL 163 190 190 VAL VAL A . n A 1 164 LEU 164 191 191 LEU LEU A . n A 1 165 CYS 165 192 192 CYS CYS A . n A 1 166 GLU 166 193 193 GLU GLU A . n A 1 167 VAL 167 194 194 VAL VAL A . n A 1 168 PHE 168 195 195 PHE PHE A . n A 1 169 CYS 169 196 196 CYS CYS A . n A 1 170 ARG 170 197 197 ARG ARG A . n A 1 171 ASP 171 198 198 ASP ASP A . n A 1 172 ARG 172 199 199 ARG ARG A . n A 1 173 LYS 173 200 200 LYS LYS A . n A 1 174 VAL 174 201 201 VAL VAL A . n A 1 175 LEU 175 202 202 LEU LEU A . n A 1 176 ARG 176 203 203 ARG ARG A . n A 1 177 GLU 177 204 204 GLU GLU A . n A 1 178 GLY 178 205 205 GLY GLY A . n A 1 179 GLU 179 206 206 GLU GLU A . n A 1 180 ARG 180 207 207 ARG ARG A . n A 1 181 LEU 181 208 208 LEU LEU A . n A 1 182 THR 182 209 209 THR THR A . n A 1 183 LEU 183 210 210 LEU LEU A . n A 1 184 PRO 184 211 211 PRO PRO A . n A 1 185 GLN 185 212 212 GLN GLN A . n A 1 186 LEU 186 213 213 LEU LEU A . n A 1 187 ALA 187 214 214 ALA ALA A . n A 1 188 ASP 188 215 215 ASP ASP A . n A 1 189 THR 189 216 216 THR THR A . n A 1 190 TYR 190 217 217 TYR TYR A . n A 1 191 GLU 191 218 218 GLU GLU A . n A 1 192 THR 192 219 219 THR THR A . n A 1 193 LEU 193 220 220 LEU LEU A . n A 1 194 ALA 194 221 221 ALA ALA A . n A 1 195 ILE 195 222 222 ILE ILE A . n A 1 196 GLU 196 223 223 GLU GLU A . n A 1 197 GLY 197 224 224 GLY GLY A . n A 1 198 ALA 198 225 225 ALA ALA A . n A 1 199 GLN 199 226 226 GLN GLN A . n A 1 200 ALA 200 227 227 ALA ALA A . n A 1 201 PHE 201 228 228 PHE PHE A . n A 1 202 TYR 202 229 229 TYR TYR A . n A 1 203 ASN 203 230 230 ASN ASN A . n A 1 204 GLY 204 231 231 GLY GLY A . n A 1 205 SER 205 232 232 SER SER A . n A 1 206 LEU 206 233 233 LEU LEU A . n A 1 207 THR 207 234 234 THR THR A . n A 1 208 ALA 208 235 235 ALA ALA A . n A 1 209 GLN 209 236 236 GLN GLN A . n A 1 210 ILE 210 237 237 ILE ILE A . n A 1 211 VAL 211 238 238 VAL VAL A . n A 1 212 LYS 212 239 239 LYS LYS A . n A 1 213 ASP 213 240 240 ASP ASP A . n A 1 214 ILE 214 241 241 ILE ILE A . n A 1 215 GLN 215 242 242 GLN GLN A . n A 1 216 ALA 216 243 243 ALA ALA A . n A 1 217 ALA 217 244 244 ALA ALA A . n A 1 218 GLY 218 245 245 GLY GLY A . n A 1 219 GLY 219 246 246 GLY GLY A . n A 1 220 ILE 220 247 247 ILE ILE A . n A 1 221 VAL 221 248 248 VAL VAL A . n A 1 222 THR 222 249 249 THR THR A . n A 1 223 ALA 223 250 250 ALA ALA A . n A 1 224 GLU 224 251 251 GLU GLU A . n A 1 225 ASP 225 252 252 ASP ASP A . n A 1 226 LEU 226 253 253 LEU LEU A . n A 1 227 ASN 227 254 254 ASN ASN A . n A 1 228 ASN 228 255 255 ASN ASN A . n A 1 229 TYR 229 256 256 TYR TYR A . n A 1 230 ARG 230 257 257 ARG ARG A . n A 1 231 ALA 231 258 258 ALA ALA A . n A 1 232 GLU 232 259 259 GLU GLU A . n A 1 233 LEU 233 260 260 LEU LEU A . n A 1 234 ILE 234 261 261 ILE ILE A . n A 1 235 GLU 235 262 262 GLU GLU A . n A 1 236 HIS 236 263 263 HIS HIS A . n A 1 237 PRO 237 264 264 PRO PRO A . n A 1 238 LEU 238 265 265 LEU LEU A . n A 1 239 ASN 239 266 266 ASN ASN A . n A 1 240 ILE 240 267 267 ILE ILE A . n A 1 241 SER 241 268 268 SER SER A . n A 1 242 LEU 242 269 269 LEU LEU A . n A 1 243 GLY 243 270 270 GLY GLY A . n A 1 244 ASP 244 271 271 ASP ASP A . n A 1 245 ALA 245 272 272 ALA ALA A . n A 1 246 VAL 246 273 273 VAL VAL A . n A 1 247 LEU 247 274 274 LEU LEU A . n A 1 248 TYR 248 275 275 TYR TYR A . n A 1 249 MET 249 276 276 MET MET A . n A 1 250 PRO 250 277 277 PRO PRO A . n A 1 251 SER 251 278 278 SER SER A . n A 1 252 ALA 252 279 279 ALA ALA A . n A 1 253 PRO 253 280 280 PRO PRO A . n A 1 254 LEU 254 281 281 LEU LEU A . n A 1 255 SER 255 282 282 SER SER A . n A 1 256 GLY 256 283 283 GLY GLY A . n A 1 257 PRO 257 284 284 PRO PRO A . n A 1 258 VAL 258 285 285 VAL VAL A . n A 1 259 LEU 259 286 286 LEU LEU A . n A 1 260 ALA 260 287 287 ALA ALA A . n A 1 261 LEU 261 288 288 LEU LEU A . n A 1 262 ILE 262 289 289 ILE ILE A . n A 1 263 LEU 263 290 290 LEU LEU A . n A 1 264 ASN 264 291 291 ASN ASN A . n A 1 265 ILE 265 292 292 ILE ILE A . n A 1 266 LEU 266 293 293 LEU LEU A . n A 1 267 LYS 267 294 294 LYS LYS A . n A 1 268 GLY 268 295 295 GLY GLY A . n A 1 269 TYR 269 296 296 TYR TYR A . n A 1 270 ASN 270 297 297 ASN ASN A . n A 1 271 PHE 271 298 298 PHE PHE A . n A 1 272 SER 272 299 299 SER SER A . n A 1 273 ARG 273 300 300 ARG ARG A . n A 1 274 GLU 274 301 301 GLU GLU A . n A 1 275 SER 275 302 302 SER SER A . n A 1 276 VAL 276 303 303 VAL VAL A . n A 1 277 GLU 277 304 304 GLU GLU A . n A 1 278 SER 278 305 305 SER SER A . n A 1 279 PRO 279 306 306 PRO PRO A . n A 1 280 GLU 280 307 307 GLU GLU A . n A 1 281 GLN 281 308 308 GLN GLN A . n A 1 282 LYS 282 309 309 LYS LYS A . n A 1 283 GLY 283 310 310 GLY GLY A . n A 1 284 LEU 284 311 311 LEU LEU A . n A 1 285 THR 285 312 312 THR THR A . n A 1 286 TYR 286 313 313 TYR TYR A . n A 1 287 HIS 287 314 314 HIS HIS A . n A 1 288 ARG 288 315 315 ARG ARG A . n A 1 289 ILE 289 316 316 ILE ILE A . n A 1 290 VAL 290 317 317 VAL VAL A . n A 1 291 GLU 291 318 318 GLU GLU A . n A 1 292 ALA 292 319 319 ALA ALA A . n A 1 293 PHE 293 320 320 PHE PHE A . n A 1 294 ARG 294 321 321 ARG ARG A . n A 1 295 PHE 295 322 322 PHE PHE A . n A 1 296 ALA 296 323 323 ALA ALA A . n A 1 297 TYR 297 324 324 TYR TYR A . n A 1 298 ALA 298 325 325 ALA ALA A . n A 1 299 LYS 299 326 326 LYS LYS A . n A 1 300 ARG 300 327 327 ARG ARG A . n A 1 301 THR 301 328 328 THR THR A . n A 1 302 LEU 302 329 329 LEU LEU A . n A 1 303 LEU 303 330 330 LEU LEU A . n A 1 304 GLY 304 331 331 GLY GLY A . n A 1 305 ASP 305 332 332 ASP ASP A . n A 1 306 PRO 306 333 333 PRO PRO A . n A 1 307 LYS 307 334 334 LYS LYS A . n A 1 308 PHE 308 335 335 PHE PHE A . n A 1 309 VAL 309 336 336 VAL VAL A . n A 1 310 ASP 310 337 337 ASP ASP A . n A 1 311 VAL 311 338 338 VAL VAL A . n A 1 312 THR 312 339 339 THR THR A . n A 1 313 GLU 313 340 340 GLU GLU A . n A 1 314 VAL 314 341 341 VAL VAL A . n A 1 315 VAL 315 342 342 VAL VAL A . n A 1 316 ARG 316 343 343 ARG ARG A . n A 1 317 ASN 317 344 344 ASN ASN A . n A 1 318 MET 318 345 345 MET MET A . n A 1 319 THR 319 346 346 THR THR A . n A 1 320 SER 320 347 347 SER SER A . n A 1 321 GLU 321 348 348 GLU GLU A . n A 1 322 PHE 322 349 349 PHE PHE A . n A 1 323 PHE 323 350 350 PHE PHE A . n A 1 324 ALA 324 351 351 ALA ALA A . n A 1 325 ALA 325 352 352 ALA ALA A . n A 1 326 GLN 326 353 353 GLN GLN A . n A 1 327 LEU 327 354 354 LEU LEU A . n A 1 328 ARG 328 355 355 ARG ARG A . n A 1 329 ALA 329 356 356 ALA ALA A . n A 1 330 GLN 330 357 357 GLN GLN A . n A 1 331 ILE 331 358 358 ILE ILE A . n A 1 332 SER 332 359 359 SER SER A . n A 1 333 ASP 333 360 360 ASP ASP A . n A 1 334 ASP 334 361 361 ASP ASP A . n A 1 335 THR 335 362 362 THR THR A . n A 1 336 THR 336 363 363 THR THR A . n A 1 337 HIS 337 364 364 HIS HIS A . n A 1 338 PRO 338 365 365 PRO PRO A . n A 1 339 ILE 339 366 366 ILE ILE A . n A 1 340 SER 340 367 367 SER SER A . n A 1 341 TYR 341 368 368 TYR TYR A . n A 1 342 TYR 342 369 369 TYR TYR A . n A 1 343 LYS 343 370 370 LYS LYS A . n A 1 344 PRO 344 371 371 PRO PRO A . n A 1 345 GLU 345 372 372 GLU GLU A . n A 1 346 PHE 346 373 373 PHE PHE A . n A 1 347 TYR 347 374 374 TYR TYR A . n A 1 348 THR 348 375 375 THR THR A . n A 1 349 PRO 349 376 ? ? ? A . n A 1 350 ASP 350 377 ? ? ? A . n A 1 351 ASP 351 378 ? ? ? A . n A 1 352 GLY 352 379 ? ? ? A . n A 1 353 GLY 353 380 ? ? ? A . n B 2 1 THR 1 381 381 THR THR B . n B 2 2 ALA 2 382 382 ALA ALA B . n B 2 3 HIS 3 383 383 HIS HIS B . n B 2 4 LEU 4 384 384 LEU LEU B . n B 2 5 SER 5 385 385 SER SER B . n B 2 6 VAL 6 386 386 VAL VAL B . n B 2 7 VAL 7 387 387 VAL VAL B . n B 2 8 ALA 8 388 388 ALA ALA B . n B 2 9 GLU 9 389 389 GLU GLU B . n B 2 10 ASP 10 390 390 ASP ASP B . n B 2 11 GLY 11 391 391 GLY GLY B . n B 2 12 SER 12 392 392 SER SER B . n B 2 13 ALA 13 393 393 ALA ALA B . n B 2 14 VAL 14 394 394 VAL VAL B . n B 2 15 SER 15 395 395 SER SER B . n B 2 16 ALA 16 396 396 ALA ALA B . n B 2 17 THR 17 397 397 THR THR B . n B 2 18 SER 18 398 398 SER SER B . n B 2 19 THR 19 399 399 THR THR B . n B 2 20 ILE 20 400 400 ILE ILE B . n B 2 21 ASN 21 401 401 ASN ASN B . n B 2 22 LEU 22 402 402 LEU LEU B . n B 2 23 TYR 23 403 403 TYR TYR B . n B 2 24 PHE 24 404 404 PHE PHE B . n B 2 25 GLY 25 405 405 GLY GLY B . n B 2 26 SER 26 406 406 SER SER B . n B 2 27 LYS 27 407 407 LYS LYS B . n B 2 28 VAL 28 408 408 VAL VAL B . n B 2 29 ARG 29 409 409 ARG ARG B . n B 2 30 SER 30 410 410 SER SER B . n B 2 31 PRO 31 411 411 PRO PRO B . n B 2 32 VAL 32 412 412 VAL VAL B . n B 2 33 SER 33 413 413 SER SER B . n B 2 34 GLY 34 414 414 GLY GLY B . n B 2 35 ILE 35 415 415 ILE ILE B . n B 2 36 LEU 36 416 416 LEU LEU B . n B 2 37 PHE 37 417 417 PHE PHE B . n B 2 38 ASN 38 418 418 ASN ASN B . n B 2 39 ASN 39 419 419 ASN ASN B . n B 2 40 GLU 40 420 420 GLU GLU B . n B 2 41 MET 41 421 421 MET MET B . n B 2 42 ASP 42 422 422 ASP ASP B . n B 2 43 ASP 43 423 423 ASP ASP B . n B 2 44 PHE 44 424 424 PHE PHE B . n B 2 45 SER 45 425 425 SER SER B . n B 2 46 SER 46 426 426 SER SER B . n B 2 47 PRO 47 427 427 PRO PRO B . n B 2 48 SER 48 428 428 SER SER B . n B 2 49 ILE 49 429 429 ILE ILE B . n B 2 50 THR 50 430 430 THR THR B . n B 2 51 ASN 51 431 431 ASN ASN B . n B 2 52 GLU 52 432 432 GLU GLU B . n B 2 53 PHE 53 433 433 PHE PHE B . n B 2 54 GLY 54 434 434 GLY GLY B . n B 2 55 VAL 55 435 435 VAL VAL B . n B 2 56 PRO 56 436 436 PRO PRO B . n B 2 57 PRO 57 437 437 PRO PRO B . n B 2 58 SER 58 438 438 SER SER B . n B 2 59 PRO 59 439 439 PRO PRO B . n B 2 60 ALA 60 440 440 ALA ALA B . n B 2 61 ASN 61 441 441 ASN ASN B . n B 2 62 PHE 62 442 442 PHE PHE B . n B 2 63 ILE 63 443 443 ILE ILE B . n B 2 64 GLN 64 444 444 GLN GLN B . n B 2 65 PRO 65 445 445 PRO PRO B . n B 2 66 GLY 66 446 446 GLY GLY B . n B 2 67 LYS 67 447 447 LYS LYS B . n B 2 68 GLN 68 448 448 GLN GLN B . n B 2 69 PRO 69 449 449 PRO PRO B . n B 2 70 LEU 70 450 450 LEU LEU B . n B 2 71 SER 71 451 451 SER SER B . n B 2 72 SER 72 452 452 SER SER B . n B 2 73 MET 73 453 453 MET MET B . n B 2 74 CYS 74 454 454 CYS CYS B . n B 2 75 PRO 75 455 455 PRO PRO B . n B 2 76 THR 76 456 456 THR THR B . n B 2 77 ILE 77 457 457 ILE ILE B . n B 2 78 MET 78 458 458 MET MET B . n B 2 79 VAL 79 459 459 VAL VAL B . n B 2 80 GLY 80 460 460 GLY GLY B . n B 2 81 GLN 81 461 461 GLN GLN B . n B 2 82 ASP 82 462 462 ASP ASP B . n B 2 83 GLY 83 463 463 GLY GLY B . n B 2 84 GLN 84 464 464 GLN GLN B . n B 2 85 VAL 85 465 465 VAL VAL B . n B 2 86 ARG 86 466 466 ARG ARG B . n B 2 87 MET 87 467 467 MET MET B . n B 2 88 VAL 88 468 468 VAL VAL B . n B 2 89 VAL 89 469 469 VAL VAL B . n B 2 90 GLY 90 470 470 GLY GLY B . n B 2 91 ALA 91 471 471 ALA ALA B . n B 2 92 ALA 92 472 472 ALA ALA B . n B 2 93 GLY 93 473 473 GLY GLY B . n B 2 94 GLY 94 474 474 GLY GLY B . n B 2 95 THR 95 475 475 THR THR B . n B 2 96 GLN 96 476 476 GLN GLN B . n B 2 97 ILE 97 477 477 ILE ILE B . n B 2 98 THR 98 478 478 THR THR B . n B 2 99 THR 99 479 479 THR THR B . n B 2 100 ALA 100 480 480 ALA ALA B . n B 2 101 THR 101 481 481 THR THR B . n B 2 102 ALA 102 482 482 ALA ALA B . n B 2 103 LEU 103 483 483 LEU LEU B . n B 2 104 ALA 104 484 484 ALA ALA B . n B 2 105 ILE 105 485 485 ILE ILE B . n B 2 106 ILE 106 486 486 ILE ILE B . n B 2 107 TYR 107 487 487 TYR TYR B . n B 2 108 ASN 108 488 488 ASN ASN B . n B 2 109 LEU 109 489 489 LEU LEU B . n B 2 110 TRP 110 490 490 TRP TRP B . n B 2 111 PHE 111 491 491 PHE PHE B . n B 2 112 GLY 112 492 492 GLY GLY B . n B 2 113 TYR 113 493 493 TYR TYR B . n B 2 114 ASP 114 494 494 ASP ASP B . n B 2 115 VAL 115 495 495 VAL VAL B . n B 2 116 LYS 116 496 496 LYS LYS B . n B 2 117 ARG 117 497 497 ARG ARG B . n B 2 118 ALA 118 498 498 ALA ALA B . n B 2 119 VAL 119 499 499 VAL VAL B . n B 2 120 GLU 120 500 500 GLU GLU B . n B 2 121 GLU 121 501 501 GLU GLU B . n B 2 122 PRO 122 502 502 PRO PRO B . n B 2 123 ARG 123 503 503 ARG ARG B . n B 2 124 LEU 124 504 504 LEU LEU B . n B 2 125 HIS 125 505 505 HIS HIS B . n B 2 126 ASN 126 506 506 ASN ASN B . n B 2 127 GLN 127 507 507 GLN GLN B . n B 2 128 LEU 128 508 508 LEU LEU B . n B 2 129 LEU 129 509 509 LEU LEU B . n B 2 130 PRO 130 510 510 PRO PRO B . n B 2 131 ASN 131 511 511 ASN ASN B . n B 2 132 VAL 132 512 512 VAL VAL B . n B 2 133 THR 133 513 513 THR THR B . n B 2 134 THR 134 514 514 THR THR B . n B 2 135 VAL 135 515 515 VAL VAL B . n B 2 136 GLU 136 516 516 GLU GLU B . n B 2 137 ARG 137 517 517 ARG ARG B . n B 2 138 ASN 138 518 518 ASN ASN B . n B 2 139 ILE 139 519 519 ILE ILE B . n B 2 140 ASP 140 520 520 ASP ASP B . n B 2 141 GLN 141 521 521 GLN GLN B . n B 2 142 ALA 142 522 522 ALA ALA B . n B 2 143 VAL 143 523 523 VAL VAL B . n B 2 144 THR 144 524 524 THR THR B . n B 2 145 ALA 145 525 525 ALA ALA B . n B 2 146 ALA 146 526 526 ALA ALA B . n B 2 147 LEU 147 527 527 LEU LEU B . n B 2 148 GLU 148 528 528 GLU GLU B . n B 2 149 THR 149 529 529 THR THR B . n B 2 150 ARG 150 530 530 ARG ARG B . n B 2 151 HIS 151 531 531 HIS HIS B . n B 2 152 HIS 152 532 532 HIS HIS B . n B 2 153 HIS 153 533 533 HIS HIS B . n B 2 154 THR 154 534 534 THR THR B . n B 2 155 GLN 155 535 535 GLN GLN B . n B 2 156 ILE 156 536 536 ILE ILE B . n B 2 157 ALA 157 537 537 ALA ALA B . n B 2 158 SER 158 538 538 SER SER B . n B 2 159 THR 159 539 539 THR THR B . n B 2 160 PHE 160 540 540 PHE PHE B . n B 2 161 ILE 161 541 541 ILE ILE B . n B 2 162 ALA 162 542 542 ALA ALA B . n B 2 163 VAL 163 543 543 VAL VAL B . n B 2 164 VAL 164 544 544 VAL VAL B . n B 2 165 GLN 165 545 545 GLN GLN B . n B 2 166 ALA 166 546 546 ALA ALA B . n B 2 167 ILE 167 547 547 ILE ILE B . n B 2 168 VAL 168 548 548 VAL VAL B . n B 2 169 ARG 169 549 549 ARG ARG B . n B 2 170 THR 170 550 550 THR THR B . n B 2 171 ALA 171 551 551 ALA ALA B . n B 2 172 GLY 172 552 552 GLY GLY B . n B 2 173 GLY 173 553 553 GLY GLY B . n B 2 174 TRP 174 554 554 TRP TRP B . n B 2 175 ALA 175 555 555 ALA ALA B . n B 2 176 ALA 176 556 556 ALA ALA B . n B 2 177 ALA 177 557 557 ALA ALA B . n B 2 178 SER 178 558 558 SER SER B . n B 2 179 ASP 179 559 559 ASP ASP B . n B 2 180 SER 180 560 560 SER SER B . n B 2 181 ARG 181 561 561 ARG ARG B . n B 2 182 LYS 182 562 562 LYS LYS B . n B 2 183 GLY 183 563 563 GLY GLY B . n B 2 184 GLY 184 564 564 GLY GLY B . n B 2 185 GLU 185 565 565 GLU GLU B . n B 2 186 PRO 186 566 566 PRO PRO B . n B 2 187 ALA 187 567 567 ALA ALA B . n B 2 188 GLY 188 568 568 GLY GLY B . n B 2 189 TYR 189 569 569 TYR TYR B . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code C 3 NAG 1 601 601 NAG NAG A . D 3 NAG 1 602 602 NAG NAG A . E 3 NAG 1 603 603 NAG NAG A . F 3 NAG 1 604 604 NAG NAG A . G 3 NAG 1 605 605 NAG NAG A . H 4 CL 1 606 1 CL CL A . I 4 CL 1 607 2 CL CL A . J 5 NA 1 608 3 NA NA A . K 3 NAG 1 1101 1101 NAG NAG B . L 6 GLU 1 1102 1 GLU GLU B . M 7 HOH 1 701 372 HOH HOH A . M 7 HOH 2 702 172 HOH HOH A . M 7 HOH 3 703 229 HOH HOH A . M 7 HOH 4 704 235 HOH HOH A . M 7 HOH 5 705 103 HOH HOH A . M 7 HOH 6 706 420 HOH HOH A . M 7 HOH 7 707 37 HOH HOH A . M 7 HOH 8 708 14 HOH HOH A . M 7 HOH 9 709 123 HOH HOH A . M 7 HOH 10 710 306 HOH HOH A . M 7 HOH 11 711 301 HOH HOH A . M 7 HOH 12 712 296 HOH HOH A . M 7 HOH 13 713 325 HOH HOH A . M 7 HOH 14 714 305 HOH HOH A . M 7 HOH 15 715 364 HOH HOH A . M 7 HOH 16 716 86 HOH HOH A . M 7 HOH 17 717 175 HOH HOH A . M 7 HOH 18 718 11 HOH HOH A . M 7 HOH 19 719 21 HOH HOH A . M 7 HOH 20 720 60 HOH HOH A . M 7 HOH 21 721 318 HOH HOH A . M 7 HOH 22 722 33 HOH HOH A . M 7 HOH 23 723 116 HOH HOH A . M 7 HOH 24 724 284 HOH HOH A . M 7 HOH 25 725 352 HOH HOH A . M 7 HOH 26 726 178 HOH HOH A . M 7 HOH 27 727 424 HOH HOH A . M 7 HOH 28 728 49 HOH HOH A . M 7 HOH 29 729 30 HOH HOH A . M 7 HOH 30 730 111 HOH HOH A . M 7 HOH 31 731 9 HOH HOH A . M 7 HOH 32 732 391 HOH HOH A . M 7 HOH 33 733 20 HOH HOH A . M 7 HOH 34 734 91 HOH HOH A . M 7 HOH 35 735 35 HOH HOH A . M 7 HOH 36 736 273 HOH HOH A . M 7 HOH 37 737 177 HOH HOH A . M 7 HOH 38 738 415 HOH HOH A . M 7 HOH 39 739 17 HOH HOH A . M 7 HOH 40 740 148 HOH HOH A . M 7 HOH 41 741 377 HOH HOH A . M 7 HOH 42 742 291 HOH HOH A . M 7 HOH 43 743 179 HOH HOH A . M 7 HOH 44 744 25 HOH HOH A . M 7 HOH 45 745 155 HOH HOH A . M 7 HOH 46 746 254 HOH HOH A . M 7 HOH 47 747 19 HOH HOH A . M 7 HOH 48 748 59 HOH HOH A . M 7 HOH 49 749 156 HOH HOH A . M 7 HOH 50 750 363 HOH HOH A . M 7 HOH 51 751 134 HOH HOH A . M 7 HOH 52 752 106 HOH HOH A . M 7 HOH 53 753 28 HOH HOH A . M 7 HOH 54 754 339 HOH HOH A . M 7 HOH 55 755 408 HOH HOH A . M 7 HOH 56 756 236 HOH HOH A . M 7 HOH 57 757 400 HOH HOH A . M 7 HOH 58 758 285 HOH HOH A . M 7 HOH 59 759 53 HOH HOH A . M 7 HOH 60 760 78 HOH HOH A . M 7 HOH 61 761 8 HOH HOH A . M 7 HOH 62 762 54 HOH HOH A . M 7 HOH 63 763 48 HOH HOH A . M 7 HOH 64 764 52 HOH HOH A . M 7 HOH 65 765 77 HOH HOH A . M 7 HOH 66 766 99 HOH HOH A . M 7 HOH 67 767 398 HOH HOH A . M 7 HOH 68 768 7 HOH HOH A . M 7 HOH 69 769 297 HOH HOH A . M 7 HOH 70 770 331 HOH HOH A . M 7 HOH 71 771 82 HOH HOH A . M 7 HOH 72 772 338 HOH HOH A . M 7 HOH 73 773 183 HOH HOH A . M 7 HOH 74 774 188 HOH HOH A . M 7 HOH 75 775 286 HOH HOH A . M 7 HOH 76 776 327 HOH HOH A . M 7 HOH 77 777 95 HOH HOH A . M 7 HOH 78 778 366 HOH HOH A . M 7 HOH 79 779 112 HOH HOH A . M 7 HOH 80 780 180 HOH HOH A . M 7 HOH 81 781 15 HOH HOH A . M 7 HOH 82 782 56 HOH HOH A . M 7 HOH 83 783 341 HOH HOH A . M 7 HOH 84 784 234 HOH HOH A . M 7 HOH 85 785 51 HOH HOH A . M 7 HOH 86 786 29 HOH HOH A . M 7 HOH 87 787 195 HOH HOH A . M 7 HOH 88 788 223 HOH HOH A . M 7 HOH 89 789 34 HOH HOH A . M 7 HOH 90 790 101 HOH HOH A . M 7 HOH 91 791 40 HOH HOH A . M 7 HOH 92 792 57 HOH HOH A . M 7 HOH 93 793 224 HOH HOH A . M 7 HOH 94 794 133 HOH HOH A . M 7 HOH 95 795 161 HOH HOH A . M 7 HOH 96 796 160 HOH HOH A . M 7 HOH 97 797 310 HOH HOH A . M 7 HOH 98 798 24 HOH HOH A . M 7 HOH 99 799 257 HOH HOH A . M 7 HOH 100 800 39 HOH HOH A . M 7 HOH 101 801 5 HOH HOH A . M 7 HOH 102 802 114 HOH HOH A . M 7 HOH 103 803 216 HOH HOH A . M 7 HOH 104 804 304 HOH HOH A . M 7 HOH 105 805 169 HOH HOH A . M 7 HOH 106 806 97 HOH HOH A . M 7 HOH 107 807 422 HOH HOH A . M 7 HOH 108 808 130 HOH HOH A . M 7 HOH 109 809 81 HOH HOH A . M 7 HOH 110 810 189 HOH HOH A . M 7 HOH 111 811 213 HOH HOH A . M 7 HOH 112 812 143 HOH HOH A . M 7 HOH 113 813 10 HOH HOH A . M 7 HOH 114 814 308 HOH HOH A . M 7 HOH 115 815 375 HOH HOH A . M 7 HOH 116 816 219 HOH HOH A . M 7 HOH 117 817 171 HOH HOH A . M 7 HOH 118 818 387 HOH HOH A . M 7 HOH 119 819 199 HOH HOH A . M 7 HOH 120 820 233 HOH HOH A . M 7 HOH 121 821 347 HOH HOH A . M 7 HOH 122 822 62 HOH HOH A . M 7 HOH 123 823 396 HOH HOH A . M 7 HOH 124 824 244 HOH HOH A . M 7 HOH 125 825 58 HOH HOH A . M 7 HOH 126 826 159 HOH HOH A . M 7 HOH 127 827 135 HOH HOH A . M 7 HOH 128 828 121 HOH HOH A . M 7 HOH 129 829 117 HOH HOH A . M 7 HOH 130 830 13 HOH HOH A . M 7 HOH 131 831 276 HOH HOH A . M 7 HOH 132 832 299 HOH HOH A . M 7 HOH 133 833 43 HOH HOH A . M 7 HOH 134 834 44 HOH HOH A . M 7 HOH 135 835 80 HOH HOH A . M 7 HOH 136 836 94 HOH HOH A . M 7 HOH 137 837 203 HOH HOH A . M 7 HOH 138 838 198 HOH HOH A . M 7 HOH 139 839 351 HOH HOH A . M 7 HOH 140 840 110 HOH HOH A . M 7 HOH 141 841 154 HOH HOH A . M 7 HOH 142 842 417 HOH HOH A . M 7 HOH 143 843 84 HOH HOH A . M 7 HOH 144 844 329 HOH HOH A . M 7 HOH 145 845 333 HOH HOH A . M 7 HOH 146 846 46 HOH HOH A . M 7 HOH 147 847 382 HOH HOH A . M 7 HOH 148 848 87 HOH HOH A . M 7 HOH 149 849 83 HOH HOH A . M 7 HOH 150 850 149 HOH HOH A . M 7 HOH 151 851 23 HOH HOH A . M 7 HOH 152 852 31 HOH HOH A . M 7 HOH 153 853 209 HOH HOH A . M 7 HOH 154 854 320 HOH HOH A . M 7 HOH 155 855 185 HOH HOH A . M 7 HOH 156 856 68 HOH HOH A . M 7 HOH 157 857 201 HOH HOH A . M 7 HOH 158 858 131 HOH HOH A . M 7 HOH 159 859 256 HOH HOH A . M 7 HOH 160 860 89 HOH HOH A . M 7 HOH 161 861 394 HOH HOH A . M 7 HOH 162 862 336 HOH HOH A . M 7 HOH 163 863 217 HOH HOH A . M 7 HOH 164 864 47 HOH HOH A . M 7 HOH 165 865 227 HOH HOH A . M 7 HOH 166 866 253 HOH HOH A . M 7 HOH 167 867 208 HOH HOH A . M 7 HOH 168 868 157 HOH HOH A . M 7 HOH 169 869 378 HOH HOH A . M 7 HOH 170 870 277 HOH HOH A . M 7 HOH 171 871 105 HOH HOH A . M 7 HOH 172 872 71 HOH HOH A . M 7 HOH 173 873 150 HOH HOH A . M 7 HOH 174 874 187 HOH HOH A . M 7 HOH 175 875 232 HOH HOH A . M 7 HOH 176 876 413 HOH HOH A . M 7 HOH 177 877 332 HOH HOH A . M 7 HOH 178 878 271 HOH HOH A . M 7 HOH 179 879 151 HOH HOH A . M 7 HOH 180 880 418 HOH HOH A . M 7 HOH 181 881 228 HOH HOH A . M 7 HOH 182 882 67 HOH HOH A . M 7 HOH 183 883 88 HOH HOH A . M 7 HOH 184 884 132 HOH HOH A . M 7 HOH 185 885 146 HOH HOH A . M 7 HOH 186 886 376 HOH HOH A . M 7 HOH 187 887 246 HOH HOH A . M 7 HOH 188 888 386 HOH HOH A . M 7 HOH 189 889 191 HOH HOH A . M 7 HOH 190 890 362 HOH HOH A . M 7 HOH 191 891 215 HOH HOH A . M 7 HOH 192 892 321 HOH HOH A . M 7 HOH 193 893 349 HOH HOH A . M 7 HOH 194 894 262 HOH HOH A . M 7 HOH 195 895 92 HOH HOH A . M 7 HOH 196 896 267 HOH HOH A . M 7 HOH 197 897 69 HOH HOH A . M 7 HOH 198 898 142 HOH HOH A . M 7 HOH 199 899 287 HOH HOH A . M 7 HOH 200 900 72 HOH HOH A . M 7 HOH 201 901 298 HOH HOH A . M 7 HOH 202 902 138 HOH HOH A . M 7 HOH 203 903 136 HOH HOH A . M 7 HOH 204 904 141 HOH HOH A . M 7 HOH 205 905 343 HOH HOH A . M 7 HOH 206 906 393 HOH HOH A . M 7 HOH 207 907 359 HOH HOH A . M 7 HOH 208 908 419 HOH HOH A . M 7 HOH 209 909 239 HOH HOH A . M 7 HOH 210 910 383 HOH HOH A . M 7 HOH 211 911 416 HOH HOH A . M 7 HOH 212 912 335 HOH HOH A . M 7 HOH 213 913 302 HOH HOH A . M 7 HOH 214 914 425 HOH HOH A . M 7 HOH 215 915 404 HOH HOH A . M 7 HOH 216 916 193 HOH HOH A . M 7 HOH 217 917 125 HOH HOH A . M 7 HOH 218 918 202 HOH HOH A . M 7 HOH 219 919 428 HOH HOH A . M 7 HOH 220 920 274 HOH HOH A . M 7 HOH 221 921 109 HOH HOH A . M 7 HOH 222 922 355 HOH HOH A . M 7 HOH 223 923 240 HOH HOH A . M 7 HOH 224 924 361 HOH HOH A . M 7 HOH 225 925 261 HOH HOH A . M 7 HOH 226 926 403 HOH HOH A . M 7 HOH 227 927 410 HOH HOH A . M 7 HOH 228 928 414 HOH HOH A . M 7 HOH 229 929 64 HOH HOH A . M 7 HOH 230 930 340 HOH HOH A . M 7 HOH 231 931 312 HOH HOH A . M 7 HOH 232 932 390 HOH HOH A . M 7 HOH 233 933 158 HOH HOH A . M 7 HOH 234 934 250 HOH HOH A . M 7 HOH 235 935 348 HOH HOH A . M 7 HOH 236 936 395 HOH HOH A . M 7 HOH 237 937 337 HOH HOH A . M 7 HOH 238 938 360 HOH HOH A . M 7 HOH 239 939 346 HOH HOH A . M 7 HOH 240 940 409 HOH HOH A . M 7 HOH 241 941 168 HOH HOH A . M 7 HOH 242 942 309 HOH HOH A . M 7 HOH 243 943 356 HOH HOH A . M 7 HOH 244 944 368 HOH HOH A . M 7 HOH 245 945 330 HOH HOH A . M 7 HOH 246 946 406 HOH HOH A . M 7 HOH 247 947 249 HOH HOH A . M 7 HOH 248 948 374 HOH HOH A . M 7 HOH 249 949 342 HOH HOH A . M 7 HOH 250 950 369 HOH HOH A . M 7 HOH 251 951 423 HOH HOH A . M 7 HOH 252 952 137 HOH HOH A . M 7 HOH 253 953 354 HOH HOH A . M 7 HOH 254 954 315 HOH HOH A . M 7 HOH 255 955 402 HOH HOH A . M 7 HOH 256 956 397 HOH HOH A . M 7 HOH 257 957 212 HOH HOH A . M 7 HOH 258 958 412 HOH HOH A . M 7 HOH 259 959 365 HOH HOH A . M 7 HOH 260 960 182 HOH HOH A . M 7 HOH 261 961 313 HOH HOH A . M 7 HOH 262 962 367 HOH HOH A . M 7 HOH 263 963 165 HOH HOH A . M 7 HOH 264 964 323 HOH HOH A . M 7 HOH 265 965 93 HOH HOH A . M 7 HOH 266 966 269 HOH HOH A . M 7 HOH 267 967 102 HOH HOH A . M 7 HOH 268 968 401 HOH HOH A . M 7 HOH 269 969 294 HOH HOH A . M 7 HOH 270 970 319 HOH HOH A . M 7 HOH 271 971 164 HOH HOH A . M 7 HOH 272 972 238 HOH HOH A . M 7 HOH 273 973 370 HOH HOH A . M 7 HOH 274 974 288 HOH HOH A . M 7 HOH 275 975 427 HOH HOH A . M 7 HOH 276 976 373 HOH HOH A . M 7 HOH 277 977 186 HOH HOH A . M 7 HOH 278 978 407 HOH HOH A . M 7 HOH 279 979 307 HOH HOH A . M 7 HOH 280 980 263 HOH HOH A . M 7 HOH 281 981 218 HOH HOH A . M 7 HOH 282 982 334 HOH HOH A . M 7 HOH 283 983 392 HOH HOH A . M 7 HOH 284 984 259 HOH HOH A . M 7 HOH 285 985 389 HOH HOH A . M 7 HOH 286 986 237 HOH HOH A . M 7 HOH 287 987 231 HOH HOH A . M 7 HOH 288 988 278 HOH HOH A . M 7 HOH 289 989 292 HOH HOH A . M 7 HOH 290 990 316 HOH HOH A . M 7 HOH 291 991 170 HOH HOH A . M 7 HOH 292 992 264 HOH HOH A . M 7 HOH 293 993 196 HOH HOH A . M 7 HOH 294 994 344 HOH HOH A . M 7 HOH 295 995 221 HOH HOH A . M 7 HOH 296 996 206 HOH HOH A . M 7 HOH 297 997 371 HOH HOH A . M 7 HOH 298 998 358 HOH HOH A . M 7 HOH 299 999 258 HOH HOH A . M 7 HOH 300 1000 345 HOH HOH A . N 7 HOH 1 1201 242 HOH HOH B . N 7 HOH 2 1202 104 HOH HOH B . N 7 HOH 3 1203 96 HOH HOH B . N 7 HOH 4 1204 197 HOH HOH B . N 7 HOH 5 1205 268 HOH HOH B . N 7 HOH 6 1206 280 HOH HOH B . N 7 HOH 7 1207 385 HOH HOH B . N 7 HOH 8 1208 120 HOH HOH B . N 7 HOH 9 1209 384 HOH HOH B . N 7 HOH 10 1210 147 HOH HOH B . N 7 HOH 11 1211 184 HOH HOH B . N 7 HOH 12 1212 128 HOH HOH B . N 7 HOH 13 1213 205 HOH HOH B . N 7 HOH 14 1214 6 HOH HOH B . N 7 HOH 15 1215 26 HOH HOH B . N 7 HOH 16 1216 119 HOH HOH B . N 7 HOH 17 1217 118 HOH HOH B . N 7 HOH 18 1218 176 HOH HOH B . N 7 HOH 19 1219 166 HOH HOH B . N 7 HOH 20 1220 36 HOH HOH B . N 7 HOH 21 1221 32 HOH HOH B . N 7 HOH 22 1222 115 HOH HOH B . N 7 HOH 23 1223 243 HOH HOH B . N 7 HOH 24 1224 113 HOH HOH B . N 7 HOH 25 1225 18 HOH HOH B . N 7 HOH 26 1226 399 HOH HOH B . N 7 HOH 27 1227 1 HOH HOH B . N 7 HOH 28 1228 173 HOH HOH B . N 7 HOH 29 1229 12 HOH HOH B . N 7 HOH 30 1230 127 HOH HOH B . N 7 HOH 31 1231 2 HOH HOH B . N 7 HOH 32 1232 144 HOH HOH B . N 7 HOH 33 1233 107 HOH HOH B . N 7 HOH 34 1234 41 HOH HOH B . N 7 HOH 35 1235 66 HOH HOH B . N 7 HOH 36 1236 76 HOH HOH B . N 7 HOH 37 1237 79 HOH HOH B . N 7 HOH 38 1238 98 HOH HOH B . N 7 HOH 39 1239 303 HOH HOH B . N 7 HOH 40 1240 16 HOH HOH B . N 7 HOH 41 1241 405 HOH HOH B . N 7 HOH 42 1242 194 HOH HOH B . N 7 HOH 43 1243 174 HOH HOH B . N 7 HOH 44 1244 55 HOH HOH B . N 7 HOH 45 1245 314 HOH HOH B . N 7 HOH 46 1246 181 HOH HOH B . N 7 HOH 47 1247 3 HOH HOH B . N 7 HOH 48 1248 27 HOH HOH B . N 7 HOH 49 1249 4 HOH HOH B . N 7 HOH 50 1250 230 HOH HOH B . N 7 HOH 51 1251 90 HOH HOH B . N 7 HOH 52 1252 289 HOH HOH B . N 7 HOH 53 1253 100 HOH HOH B . N 7 HOH 54 1254 204 HOH HOH B . N 7 HOH 55 1255 300 HOH HOH B . N 7 HOH 56 1256 50 HOH HOH B . N 7 HOH 57 1257 108 HOH HOH B . N 7 HOH 58 1258 45 HOH HOH B . N 7 HOH 59 1259 211 HOH HOH B . N 7 HOH 60 1260 74 HOH HOH B . N 7 HOH 61 1261 75 HOH HOH B . N 7 HOH 62 1262 326 HOH HOH B . N 7 HOH 63 1263 282 HOH HOH B . N 7 HOH 64 1264 295 HOH HOH B . N 7 HOH 65 1265 61 HOH HOH B . N 7 HOH 66 1266 220 HOH HOH B . N 7 HOH 67 1267 38 HOH HOH B . N 7 HOH 68 1268 163 HOH HOH B . N 7 HOH 69 1269 207 HOH HOH B . N 7 HOH 70 1270 247 HOH HOH B . N 7 HOH 71 1271 139 HOH HOH B . N 7 HOH 72 1272 190 HOH HOH B . N 7 HOH 73 1273 22 HOH HOH B . N 7 HOH 74 1274 251 HOH HOH B . N 7 HOH 75 1275 167 HOH HOH B . N 7 HOH 76 1276 162 HOH HOH B . N 7 HOH 77 1277 214 HOH HOH B . N 7 HOH 78 1278 283 HOH HOH B . N 7 HOH 79 1279 152 HOH HOH B . N 7 HOH 80 1280 322 HOH HOH B . N 7 HOH 81 1281 357 HOH HOH B . N 7 HOH 82 1282 73 HOH HOH B . N 7 HOH 83 1283 411 HOH HOH B . N 7 HOH 84 1284 124 HOH HOH B . N 7 HOH 85 1285 200 HOH HOH B . N 7 HOH 86 1286 42 HOH HOH B . N 7 HOH 87 1287 328 HOH HOH B . N 7 HOH 88 1288 140 HOH HOH B . N 7 HOH 89 1289 248 HOH HOH B . N 7 HOH 90 1290 281 HOH HOH B . N 7 HOH 91 1291 255 HOH HOH B . N 7 HOH 92 1292 222 HOH HOH B . N 7 HOH 93 1293 350 HOH HOH B . N 7 HOH 94 1294 192 HOH HOH B . N 7 HOH 95 1295 426 HOH HOH B . N 7 HOH 96 1296 122 HOH HOH B . N 7 HOH 97 1297 85 HOH HOH B . N 7 HOH 98 1298 311 HOH HOH B . N 7 HOH 99 1299 252 HOH HOH B . N 7 HOH 100 1300 279 HOH HOH B . N 7 HOH 101 1301 272 HOH HOH B . N 7 HOH 102 1302 421 HOH HOH B . N 7 HOH 103 1303 260 HOH HOH B . N 7 HOH 104 1304 210 HOH HOH B . N 7 HOH 105 1305 270 HOH HOH B . N 7 HOH 106 1306 153 HOH HOH B . N 7 HOH 107 1307 388 HOH HOH B . N 7 HOH 108 1308 293 HOH HOH B . N 7 HOH 109 1309 380 HOH HOH B . N 7 HOH 110 1310 317 HOH HOH B . N 7 HOH 111 1311 225 HOH HOH B . N 7 HOH 112 1312 129 HOH HOH B . N 7 HOH 113 1313 65 HOH HOH B . N 7 HOH 114 1314 241 HOH HOH B . N 7 HOH 115 1315 126 HOH HOH B . N 7 HOH 116 1316 290 HOH HOH B . N 7 HOH 117 1317 245 HOH HOH B . N 7 HOH 118 1318 226 HOH HOH B . N 7 HOH 119 1319 70 HOH HOH B . N 7 HOH 120 1320 63 HOH HOH B . N 7 HOH 121 1321 145 HOH HOH B . N 7 HOH 122 1322 379 HOH HOH B . N 7 HOH 123 1323 381 HOH HOH B . N 7 HOH 124 1324 275 HOH HOH B . N 7 HOH 125 1325 353 HOH HOH B . N 7 HOH 126 1326 265 HOH HOH B . N 7 HOH 127 1327 266 HOH HOH B . N 7 HOH 128 1328 324 HOH HOH B . # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_and_software_defined_assembly _pdbx_struct_assembly.method_details PISA _pdbx_struct_assembly.oligomeric_details dimeric _pdbx_struct_assembly.oligomeric_count 2 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G,H,I,J,K,L,M,N # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 1 'ABSA (A^2)' 14540 ? 1 MORE -92 ? 1 'SSA (A^2)' 19640 ? # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # _pdbx_struct_special_symmetry.id 1 _pdbx_struct_special_symmetry.PDB_model_num 1 _pdbx_struct_special_symmetry.auth_asym_id A _pdbx_struct_special_symmetry.auth_comp_id HOH _pdbx_struct_special_symmetry.auth_seq_id 948 _pdbx_struct_special_symmetry.PDB_ins_code ? _pdbx_struct_special_symmetry.label_asym_id M _pdbx_struct_special_symmetry.label_comp_id HOH _pdbx_struct_special_symmetry.label_seq_id . # loop_ _pdbx_struct_conn_angle.id _pdbx_struct_conn_angle.ptnr1_label_atom_id _pdbx_struct_conn_angle.ptnr1_label_alt_id _pdbx_struct_conn_angle.ptnr1_label_asym_id _pdbx_struct_conn_angle.ptnr1_label_comp_id _pdbx_struct_conn_angle.ptnr1_label_seq_id _pdbx_struct_conn_angle.ptnr1_auth_atom_id _pdbx_struct_conn_angle.ptnr1_auth_asym_id _pdbx_struct_conn_angle.ptnr1_auth_comp_id _pdbx_struct_conn_angle.ptnr1_auth_seq_id _pdbx_struct_conn_angle.ptnr1_PDB_ins_code _pdbx_struct_conn_angle.ptnr1_symmetry _pdbx_struct_conn_angle.ptnr2_label_atom_id _pdbx_struct_conn_angle.ptnr2_label_alt_id _pdbx_struct_conn_angle.ptnr2_label_asym_id _pdbx_struct_conn_angle.ptnr2_label_comp_id _pdbx_struct_conn_angle.ptnr2_label_seq_id _pdbx_struct_conn_angle.ptnr2_auth_atom_id _pdbx_struct_conn_angle.ptnr2_auth_asym_id _pdbx_struct_conn_angle.ptnr2_auth_comp_id _pdbx_struct_conn_angle.ptnr2_auth_seq_id _pdbx_struct_conn_angle.ptnr2_PDB_ins_code _pdbx_struct_conn_angle.ptnr2_symmetry _pdbx_struct_conn_angle.ptnr3_label_atom_id _pdbx_struct_conn_angle.ptnr3_label_alt_id _pdbx_struct_conn_angle.ptnr3_label_asym_id _pdbx_struct_conn_angle.ptnr3_label_comp_id _pdbx_struct_conn_angle.ptnr3_label_seq_id _pdbx_struct_conn_angle.ptnr3_auth_atom_id _pdbx_struct_conn_angle.ptnr3_auth_asym_id _pdbx_struct_conn_angle.ptnr3_auth_comp_id _pdbx_struct_conn_angle.ptnr3_auth_seq_id _pdbx_struct_conn_angle.ptnr3_PDB_ins_code _pdbx_struct_conn_angle.ptnr3_symmetry _pdbx_struct_conn_angle.value _pdbx_struct_conn_angle.value_esd 1 O ? B ALA 176 ? B ALA 556 ? 1_555 NA ? J NA . ? A NA 608 ? 1_555 O ? M HOH . ? A HOH 934 ? 1_555 137.8 ? 2 O ? B ALA 176 ? B ALA 556 ? 1_555 NA ? J NA . ? A NA 608 ? 1_555 O ? N HOH . ? B HOH 1235 ? 1_555 104.4 ? 3 O ? M HOH . ? A HOH 934 ? 1_555 NA ? J NA . ? A NA 608 ? 1_555 O ? N HOH . ? B HOH 1235 ? 1_555 117.1 ? # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2015-06-03 2 'Structure model' 1 1 2015-06-10 3 'Structure model' 1 2 2015-07-29 4 'Structure model' 1 3 2017-09-20 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Database references' 2 3 'Structure model' 'Database references' 3 4 'Structure model' 'Author supporting evidence' 4 4 'Structure model' 'Database references' 5 4 'Structure model' 'Derived calculations' 6 4 'Structure model' 'Source and taxonomy' # loop_ _pdbx_audit_revision_category.ordinal _pdbx_audit_revision_category.revision_ordinal _pdbx_audit_revision_category.data_content_type _pdbx_audit_revision_category.category 1 4 'Structure model' citation 2 4 'Structure model' entity_src_gen 3 4 'Structure model' pdbx_audit_support 4 4 'Structure model' pdbx_struct_oper_list # loop_ _pdbx_audit_revision_item.ordinal _pdbx_audit_revision_item.revision_ordinal _pdbx_audit_revision_item.data_content_type _pdbx_audit_revision_item.item 1 4 'Structure model' '_citation.journal_id_CSD' 2 4 'Structure model' '_entity_src_gen.pdbx_alt_source_flag' 3 4 'Structure model' '_pdbx_audit_support.funding_organization' 4 4 'Structure model' '_pdbx_struct_oper_list.symmetry_operation' # loop_ _software.citation_id _software.classification _software.compiler_name _software.compiler_version _software.contact_author _software.contact_author_email _software.date _software.description _software.dependencies _software.hardware _software.language _software.location _software.mods _software.name _software.os _software.os_version _software.type _software.version _software.pdbx_ordinal ? 'data collection' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? . 1 ? 'data scaling' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? . 2 ? refinement ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0073 3 ? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? 3.15 4 ? phasing ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0073 5 ? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? . 6 # loop_ _pdbx_validate_close_contact.id _pdbx_validate_close_contact.PDB_model_num _pdbx_validate_close_contact.auth_atom_id_1 _pdbx_validate_close_contact.auth_asym_id_1 _pdbx_validate_close_contact.auth_comp_id_1 _pdbx_validate_close_contact.auth_seq_id_1 _pdbx_validate_close_contact.PDB_ins_code_1 _pdbx_validate_close_contact.label_alt_id_1 _pdbx_validate_close_contact.auth_atom_id_2 _pdbx_validate_close_contact.auth_asym_id_2 _pdbx_validate_close_contact.auth_comp_id_2 _pdbx_validate_close_contact.auth_seq_id_2 _pdbx_validate_close_contact.PDB_ins_code_2 _pdbx_validate_close_contact.label_alt_id_2 _pdbx_validate_close_contact.dist 1 1 O A HOH 950 ? ? O A HOH 975 ? ? 2.11 2 1 O A THR 339 ? ? O A HOH 701 ? ? 2.12 3 1 O A HOH 938 ? ? O A HOH 973 ? ? 2.14 # _pdbx_validate_rmsd_angle.id 1 _pdbx_validate_rmsd_angle.PDB_model_num 1 _pdbx_validate_rmsd_angle.auth_atom_id_1 NE _pdbx_validate_rmsd_angle.auth_asym_id_1 A _pdbx_validate_rmsd_angle.auth_comp_id_1 ARG _pdbx_validate_rmsd_angle.auth_seq_id_1 355 _pdbx_validate_rmsd_angle.PDB_ins_code_1 ? _pdbx_validate_rmsd_angle.label_alt_id_1 ? _pdbx_validate_rmsd_angle.auth_atom_id_2 CZ _pdbx_validate_rmsd_angle.auth_asym_id_2 A _pdbx_validate_rmsd_angle.auth_comp_id_2 ARG _pdbx_validate_rmsd_angle.auth_seq_id_2 355 _pdbx_validate_rmsd_angle.PDB_ins_code_2 ? _pdbx_validate_rmsd_angle.label_alt_id_2 ? _pdbx_validate_rmsd_angle.auth_atom_id_3 NH2 _pdbx_validate_rmsd_angle.auth_asym_id_3 A _pdbx_validate_rmsd_angle.auth_comp_id_3 ARG _pdbx_validate_rmsd_angle.auth_seq_id_3 355 _pdbx_validate_rmsd_angle.PDB_ins_code_3 ? _pdbx_validate_rmsd_angle.label_alt_id_3 ? _pdbx_validate_rmsd_angle.angle_value 117.05 _pdbx_validate_rmsd_angle.angle_target_value 120.30 _pdbx_validate_rmsd_angle.angle_deviation -3.25 _pdbx_validate_rmsd_angle.angle_standard_deviation 0.50 _pdbx_validate_rmsd_angle.linker_flag N # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 ASN A 230 ? ? -157.71 58.64 2 1 ASN B 401 ? ? 81.26 -109.98 3 1 CYS B 454 ? ? -160.44 66.21 4 1 CYS B 454 ? ? -157.47 60.12 5 1 LEU B 508 ? ? 77.55 -56.97 6 1 ASN B 511 ? ? -101.17 70.76 7 1 THR B 539 ? ? -111.43 -91.22 8 1 ALA B 542 ? ? 68.93 175.62 # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 Y 1 A ARG 199 ? NE ? A ARG 172 NE 2 1 Y 1 A ARG 199 ? CZ ? A ARG 172 CZ 3 1 Y 1 A ARG 199 ? NH1 ? A ARG 172 NH1 4 1 Y 1 A ARG 199 ? NH2 ? A ARG 172 NH2 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A SER 28 ? A SER 1 2 1 Y 1 A ALA 29 ? A ALA 2 3 1 Y 1 A SER 30 ? A SER 3 4 1 Y 1 A LYS 31 ? A LYS 4 5 1 Y 1 A GLU 32 ? A GLU 5 6 1 Y 1 A PRO 33 ? A PRO 6 7 1 Y 1 A PRO 376 ? A PRO 349 8 1 Y 1 A ASP 377 ? A ASP 350 9 1 Y 1 A ASP 378 ? A ASP 351 10 1 Y 1 A GLY 379 ? A GLY 352 11 1 Y 1 A GLY 380 ? A GLY 353 # _pdbx_audit_support.funding_organization 'National Institutes of Health/National Institute of General Medical Sciences' _pdbx_audit_support.country 'United States' _pdbx_audit_support.grant_number P20GM103640 _pdbx_audit_support.ordinal 1 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 3 N-ACETYL-D-GLUCOSAMINE NAG 4 'CHLORIDE ION' CL 5 'SODIUM ION' NA 6 'GLUTAMIC ACID' GLU 7 water HOH #