data_4XX3 # _entry.id 4XX3 # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.292 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 4XX3 WWPDB D_1000206448 # _pdbx_database_related.content_type unspecified _pdbx_database_related.db_id 4XX4 _pdbx_database_related.db_name PDB _pdbx_database_related.details . # _pdbx_database_status.status_code REL _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.entry_id 4XX3 _pdbx_database_status.recvd_initial_deposition_date 2015-01-29 _pdbx_database_status.SG_entry N _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? _pdbx_database_status.pdb_format_compatible Y # _audit_author.name 'Orth, P.' _audit_author.pdbx_ordinal 1 # _citation.abstract ? _citation.abstract_id_CAS ? _citation.book_id_ISBN ? _citation.book_publisher ? _citation.book_publisher_city ? _citation.book_title ? _citation.coordinate_linkage ? _citation.country UK _citation.database_id_Medline ? _citation.details ? _citation.id primary _citation.journal_abbrev 'Bioorg. Med. Chem. Lett.' _citation.journal_id_ASTM BMCLE8 _citation.journal_id_CSD 1127 _citation.journal_id_ISSN 1464-3405 _citation.journal_full ? _citation.journal_issue ? _citation.journal_volume 25 _citation.language ? _citation.page_first 1592 _citation.page_last 1596 _citation.title 'Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.' _citation.year 2015 _citation.database_id_CSD ? _citation.pdbx_database_id_DOI 10.1016/j.bmcl.2015.02.003 _citation.pdbx_database_id_PubMed 25728416 _citation.unpublished_flag ? # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'McKittrick, B.A.' 1 primary 'Caldwell, J.P.' 2 primary 'Bara, T.' 3 primary 'Boykow, G.' 4 primary 'Chintala, M.' 5 primary 'Clader, J.' 6 primary 'Czarniecki, M.' 7 primary 'Courneya, B.' 8 primary 'Duffy, R.' 9 primary 'Fleming, L.' 10 primary 'Giessert, R.' 11 primary 'Greenlee, W.J.' 12 primary 'Heap, C.' 13 primary 'Hong, L.' 14 primary 'Huang, Y.' 15 primary 'Iserloh, U.' 16 primary 'Josien, H.' 17 primary 'Khan, T.' 18 primary 'Korfmacher, W.' 19 primary 'Liang, X.' 20 primary 'Mazzola, R.' 21 primary 'Mitra, S.' 22 primary 'Moore, K.' 23 primary 'Orth, P.' 24 primary 'Rajagopalan, M.' 25 primary 'Roy, S.' 26 primary 'Sakwa, S.' 27 primary 'Strickland, C.' 28 primary 'Vaccaro, H.' 29 primary 'Voigt, J.' 30 primary 'Wang, H.' 31 primary 'Wong, J.' 32 primary 'Zhang, R.' 33 primary 'Zych, A.' 34 # _cell.angle_alpha 90.000 _cell.angle_alpha_esd ? _cell.angle_beta 90.000 _cell.angle_beta_esd ? _cell.angle_gamma 90.000 _cell.angle_gamma_esd ? _cell.entry_id 4XX3 _cell.details ? _cell.formula_units_Z ? _cell.length_a 142.020 _cell.length_a_esd ? _cell.length_b 142.020 _cell.length_b_esd ? _cell.length_c 142.020 _cell.length_c_esd ? _cell.volume ? _cell.volume_esd ? _cell.Z_PDB 24 _cell.reciprocal_angle_alpha ? _cell.reciprocal_angle_beta ? _cell.reciprocal_angle_gamma ? _cell.reciprocal_angle_alpha_esd ? _cell.reciprocal_angle_beta_esd ? _cell.reciprocal_angle_gamma_esd ? _cell.reciprocal_length_a ? _cell.reciprocal_length_b ? _cell.reciprocal_length_c ? _cell.reciprocal_length_a_esd ? _cell.reciprocal_length_b_esd ? _cell.reciprocal_length_c_esd ? _cell.pdbx_unique_axis ? # _symmetry.entry_id 4XX3 _symmetry.cell_setting ? _symmetry.Int_Tables_number 198 _symmetry.space_group_name_Hall ? _symmetry.space_group_name_H-M 'P 21 3' _symmetry.pdbx_full_space_group_name_H-M ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man Renin 37267.008 2 3.4.23.15 ? ? ? 2 non-polymer syn N-ACETYL-D-GLUCOSAMINE 221.208 2 ? ? ? ? 3 non-polymer syn 'N-benzyl-3-{[(2Z,4S)-2-imino-4-methyl-6-oxo-4-(propan-2-yl)tetrahydropyrimidin-1(2H)-yl]methyl}benzamide' 392.494 2 ? ? ? ? 4 water nat water 18.015 277 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name Angiotensinogenase # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELT LRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF YYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE KLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFI RKFYTEFDRRNNRIGFALAR ; _entity_poly.pdbx_seq_one_letter_code_can ;LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELT LRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF YYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE KLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFI RKFYTEFDRRNNRIGFALAR ; _entity_poly.pdbx_strand_id A,B _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 LEU n 1 2 THR n 1 3 LEU n 1 4 GLY n 1 5 ASN n 1 6 THR n 1 7 THR n 1 8 SER n 1 9 SER n 1 10 VAL n 1 11 ILE n 1 12 LEU n 1 13 THR n 1 14 ASN n 1 15 TYR n 1 16 MET n 1 17 ASP n 1 18 THR n 1 19 GLN n 1 20 TYR n 1 21 TYR n 1 22 GLY n 1 23 GLU n 1 24 ILE n 1 25 GLY n 1 26 ILE n 1 27 GLY n 1 28 THR n 1 29 PRO n 1 30 PRO n 1 31 GLN n 1 32 THR n 1 33 PHE n 1 34 LYS n 1 35 VAL n 1 36 VAL n 1 37 PHE n 1 38 ASP n 1 39 THR n 1 40 GLY n 1 41 SER n 1 42 SER n 1 43 ASN n 1 44 VAL n 1 45 TRP n 1 46 VAL n 1 47 PRO n 1 48 SER n 1 49 SER n 1 50 LYS n 1 51 CYS n 1 52 SER n 1 53 ARG n 1 54 LEU n 1 55 TYR n 1 56 THR n 1 57 ALA n 1 58 CYS n 1 59 VAL n 1 60 TYR n 1 61 HIS n 1 62 LYS n 1 63 LEU n 1 64 PHE n 1 65 ASP n 1 66 ALA n 1 67 SER n 1 68 ASP n 1 69 SER n 1 70 SER n 1 71 SER n 1 72 TYR n 1 73 LYS n 1 74 HIS n 1 75 ASN n 1 76 GLY n 1 77 THR n 1 78 GLU n 1 79 LEU n 1 80 THR n 1 81 LEU n 1 82 ARG n 1 83 TYR n 1 84 SER n 1 85 THR n 1 86 GLY n 1 87 THR n 1 88 VAL n 1 89 SER n 1 90 GLY n 1 91 PHE n 1 92 LEU n 1 93 SER n 1 94 GLN n 1 95 ASP n 1 96 ILE n 1 97 ILE n 1 98 THR n 1 99 VAL n 1 100 GLY n 1 101 GLY n 1 102 ILE n 1 103 THR n 1 104 VAL n 1 105 THR n 1 106 GLN n 1 107 MET n 1 108 PHE n 1 109 GLY n 1 110 GLU n 1 111 VAL n 1 112 THR n 1 113 GLU n 1 114 MET n 1 115 PRO n 1 116 ALA n 1 117 LEU n 1 118 PRO n 1 119 PHE n 1 120 MET n 1 121 LEU n 1 122 ALA n 1 123 GLU n 1 124 PHE n 1 125 ASP n 1 126 GLY n 1 127 VAL n 1 128 VAL n 1 129 GLY n 1 130 MET n 1 131 GLY n 1 132 PHE n 1 133 ILE n 1 134 GLU n 1 135 GLN n 1 136 ALA n 1 137 ILE n 1 138 GLY n 1 139 ARG n 1 140 VAL n 1 141 THR n 1 142 PRO n 1 143 ILE n 1 144 PHE n 1 145 ASP n 1 146 ASN n 1 147 ILE n 1 148 ILE n 1 149 SER n 1 150 GLN n 1 151 GLY n 1 152 VAL n 1 153 LEU n 1 154 LYS n 1 155 GLU n 1 156 ASP n 1 157 VAL n 1 158 PHE n 1 159 SER n 1 160 PHE n 1 161 TYR n 1 162 TYR n 1 163 ASN n 1 164 ARG n 1 165 ASP n 1 166 SER n 1 167 GLU n 1 168 ASN n 1 169 SER n 1 170 GLN n 1 171 SER n 1 172 LEU n 1 173 GLY n 1 174 GLY n 1 175 GLN n 1 176 ILE n 1 177 VAL n 1 178 LEU n 1 179 GLY n 1 180 GLY n 1 181 SER n 1 182 ASP n 1 183 PRO n 1 184 GLN n 1 185 HIS n 1 186 TYR n 1 187 GLU n 1 188 GLY n 1 189 ASN n 1 190 PHE n 1 191 HIS n 1 192 TYR n 1 193 ILE n 1 194 ASN n 1 195 LEU n 1 196 ILE n 1 197 LYS n 1 198 THR n 1 199 GLY n 1 200 VAL n 1 201 TRP n 1 202 GLN n 1 203 ILE n 1 204 GLN n 1 205 MET n 1 206 LYS n 1 207 GLY n 1 208 VAL n 1 209 SER n 1 210 VAL n 1 211 GLY n 1 212 SER n 1 213 SER n 1 214 THR n 1 215 LEU n 1 216 LEU n 1 217 CYS n 1 218 GLU n 1 219 ASP n 1 220 GLY n 1 221 CYS n 1 222 LEU n 1 223 ALA n 1 224 LEU n 1 225 VAL n 1 226 ASP n 1 227 THR n 1 228 GLY n 1 229 ALA n 1 230 SER n 1 231 TYR n 1 232 ILE n 1 233 SER n 1 234 GLY n 1 235 SER n 1 236 THR n 1 237 SER n 1 238 SER n 1 239 ILE n 1 240 GLU n 1 241 LYS n 1 242 LEU n 1 243 MET n 1 244 GLU n 1 245 ALA n 1 246 LEU n 1 247 GLY n 1 248 ALA n 1 249 LYS n 1 250 LYS n 1 251 ARG n 1 252 LEU n 1 253 PHE n 1 254 ASP n 1 255 TYR n 1 256 VAL n 1 257 VAL n 1 258 LYS n 1 259 CYS n 1 260 ASN n 1 261 GLU n 1 262 GLY n 1 263 PRO n 1 264 THR n 1 265 LEU n 1 266 PRO n 1 267 ASP n 1 268 ILE n 1 269 SER n 1 270 PHE n 1 271 HIS n 1 272 LEU n 1 273 GLY n 1 274 GLY n 1 275 LYS n 1 276 GLU n 1 277 TYR n 1 278 THR n 1 279 LEU n 1 280 THR n 1 281 SER n 1 282 ALA n 1 283 ASP n 1 284 TYR n 1 285 VAL n 1 286 PHE n 1 287 GLN n 1 288 GLU n 1 289 SER n 1 290 TYR n 1 291 SER n 1 292 SER n 1 293 LYS n 1 294 LYS n 1 295 LEU n 1 296 CYS n 1 297 THR n 1 298 LEU n 1 299 ALA n 1 300 ILE n 1 301 HIS n 1 302 ALA n 1 303 MET n 1 304 ASP n 1 305 ILE n 1 306 PRO n 1 307 PRO n 1 308 PRO n 1 309 THR n 1 310 GLY n 1 311 PRO n 1 312 THR n 1 313 TRP n 1 314 ALA n 1 315 LEU n 1 316 GLY n 1 317 ALA n 1 318 THR n 1 319 PHE n 1 320 ILE n 1 321 ARG n 1 322 LYS n 1 323 PHE n 1 324 TYR n 1 325 THR n 1 326 GLU n 1 327 PHE n 1 328 ASP n 1 329 ARG n 1 330 ARG n 1 331 ASN n 1 332 ASN n 1 333 ARG n 1 334 ILE n 1 335 GLY n 1 336 PHE n 1 337 ALA n 1 338 LEU n 1 339 ALA n 1 340 ARG n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type 'Biological sequence' _entity_src_gen.pdbx_beg_seq_num 1 _entity_src_gen.pdbx_end_seq_num 340 _entity_src_gen.gene_src_common_name Human _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene REN _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Homo sapiens' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 9606 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'Homo sapiens' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 9606 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain ? _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line '293 HEK' _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type ? _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name ? _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code RENI_HUMAN _struct_ref.pdbx_db_accession P00797 _struct_ref.pdbx_db_isoform ? _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELT LRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF YYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE KLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFI RKFYTEFDRRNNRIGFALAR ; _struct_ref.pdbx_align_begin 67 # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 4XX3 A 1 ? 340 ? P00797 67 ? 406 ? 67 406 2 1 4XX3 B 1 ? 340 ? P00797 67 ? 406 ? 67 406 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight 70X non-polymer . 'N-benzyl-3-{[(2Z,4S)-2-imino-4-methyl-6-oxo-4-(propan-2-yl)tetrahydropyrimidin-1(2H)-yl]methyl}benzamide' ? 'C23 H28 N4 O2' 392.494 ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.absorpt_coefficient_mu ? _exptl.absorpt_correction_T_max ? _exptl.absorpt_correction_T_min ? _exptl.absorpt_correction_type ? _exptl.absorpt_process_details ? _exptl.entry_id 4XX3 _exptl.crystals_number 1 _exptl.details ? _exptl.method 'X-RAY DIFFRACTION' _exptl.method_details ? # _exptl_crystal.colour ? _exptl_crystal.density_diffrn ? _exptl_crystal.density_Matthews 3.22 _exptl_crystal.density_method ? _exptl_crystal.density_percent_sol 61.86 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.id 1 _exptl_crystal.preparation ? _exptl_crystal.size_max ? _exptl_crystal.size_mid ? _exptl_crystal.size_min ? _exptl_crystal.size_rad ? _exptl_crystal.colour_lustre ? _exptl_crystal.colour_modifier ? _exptl_crystal.colour_primary ? _exptl_crystal.density_meas ? _exptl_crystal.density_meas_esd ? _exptl_crystal.density_meas_gt ? _exptl_crystal.density_meas_lt ? _exptl_crystal.density_meas_temp ? _exptl_crystal.density_meas_temp_esd ? _exptl_crystal.density_meas_temp_gt ? _exptl_crystal.density_meas_temp_lt ? _exptl_crystal.pdbx_crystal_image_url ? _exptl_crystal.pdbx_crystal_image_format ? _exptl_crystal.pdbx_mosaicity ? _exptl_crystal.pdbx_mosaicity_esd ? # _exptl_crystal_grow.apparatus ? _exptl_crystal_grow.atmosphere ? _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.details ? _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.method_ref ? _exptl_crystal_grow.pH ? _exptl_crystal_grow.pressure ? _exptl_crystal_grow.pressure_esd ? _exptl_crystal_grow.seeding ? _exptl_crystal_grow.seeding_ref ? _exptl_crystal_grow.temp 295 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.temp_esd ? _exptl_crystal_grow.time ? _exptl_crystal_grow.pdbx_details 'Reservoir 15% PEG3350, 625 mM NaCl and citrate buffer pH 4.6' _exptl_crystal_grow.pdbx_pH_range ? # _diffrn.ambient_environment ? _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.ambient_temp_esd ? _diffrn.crystal_id 1 _diffrn.crystal_support ? _diffrn.crystal_treatment ? _diffrn.details ? _diffrn.id 1 _diffrn.ambient_pressure ? _diffrn.ambient_pressure_esd ? _diffrn.ambient_pressure_gt ? _diffrn.ambient_pressure_lt ? _diffrn.ambient_temp_gt ? _diffrn.ambient_temp_lt ? # _diffrn_detector.details ? _diffrn_detector.detector 'IMAGE PLATE' _diffrn_detector.diffrn_id 1 _diffrn_detector.type 'RIGAKU RAXIS IV' _diffrn_detector.area_resol_mean ? _diffrn_detector.dtime ? _diffrn_detector.pdbx_frames_total ? _diffrn_detector.pdbx_collection_time_total ? _diffrn_detector.pdbx_collection_date 2009-05-27 # _diffrn_radiation.collimation ? _diffrn_radiation.diffrn_id 1 _diffrn_radiation.filter_edge ? _diffrn_radiation.inhomogeneity ? _diffrn_radiation.monochromator ? _diffrn_radiation.polarisn_norm ? _diffrn_radiation.polarisn_ratio ? _diffrn_radiation.probe ? _diffrn_radiation.type ? _diffrn_radiation.xray_symbol ? _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.pdbx_wavelength_list ? _diffrn_radiation.pdbx_wavelength ? _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_analyzer ? _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 1.54178 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.current ? _diffrn_source.details ? _diffrn_source.diffrn_id 1 _diffrn_source.power ? _diffrn_source.size ? _diffrn_source.source 'ROTATING ANODE' _diffrn_source.target ? _diffrn_source.type 'RIGAKU FR-E DW' _diffrn_source.voltage ? _diffrn_source.take-off_angle ? _diffrn_source.pdbx_wavelength_list 1.54178 _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_synchrotron_beamline ? _diffrn_source.pdbx_synchrotron_site ? # _reflns.B_iso_Wilson_estimate ? _reflns.entry_id 4XX3 _reflns.data_reduction_details ? _reflns.data_reduction_method ? _reflns.d_resolution_high 2.400 _reflns.d_resolution_low 50.000 _reflns.details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.number_all ? _reflns.number_obs 36678 _reflns.observed_criterion ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.observed_criterion_I_max ? _reflns.observed_criterion_I_min ? _reflns.observed_criterion_sigma_F ? _reflns.observed_criterion_sigma_I ? _reflns.percent_possible_obs 97.400 _reflns.R_free_details ? _reflns.Rmerge_F_all ? _reflns.Rmerge_F_obs ? _reflns.Friedel_coverage ? _reflns.number_gt ? _reflns.threshold_expression ? _reflns.pdbx_redundancy 3.400 _reflns.pdbx_Rmerge_I_obs 0.100 _reflns.pdbx_Rmerge_I_all ? _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_av_sigmaI 8.982 _reflns.pdbx_netI_over_sigmaI 11.100 _reflns.pdbx_res_netI_over_av_sigmaI_2 ? _reflns.pdbx_res_netI_over_sigmaI_2 ? _reflns.pdbx_chi_squared 1.069 _reflns.pdbx_scaling_rejects ? _reflns.pdbx_d_res_high_opt ? _reflns.pdbx_d_res_low_opt ? _reflns.pdbx_d_res_opt_method ? _reflns.phase_calculation_details ? _reflns.pdbx_Rrim_I_all ? _reflns.pdbx_Rpim_I_all ? _reflns.pdbx_d_opt ? _reflns.pdbx_number_measured_all 123848 _reflns.pdbx_diffrn_id 1 _reflns.pdbx_ordinal 1 _reflns.pdbx_CC_half ? _reflns.pdbx_R_split ? # loop_ _reflns_shell.d_res_high _reflns_shell.d_res_low _reflns_shell.meanI_over_sigI_all _reflns_shell.meanI_over_sigI_obs _reflns_shell.number_measured_all _reflns_shell.number_measured_obs _reflns_shell.number_possible _reflns_shell.number_unique_all _reflns_shell.number_unique_obs _reflns_shell.percent_possible_all _reflns_shell.percent_possible_obs _reflns_shell.Rmerge_F_all _reflns_shell.Rmerge_F_obs _reflns_shell.Rmerge_I_all _reflns_shell.Rmerge_I_obs _reflns_shell.meanI_over_sigI_gt _reflns_shell.meanI_over_uI_all _reflns_shell.meanI_over_uI_gt _reflns_shell.number_measured_gt _reflns_shell.number_unique_gt _reflns_shell.percent_possible_gt _reflns_shell.Rmerge_F_gt _reflns_shell.Rmerge_I_gt _reflns_shell.pdbx_redundancy _reflns_shell.pdbx_Rsym_value _reflns_shell.pdbx_chi_squared _reflns_shell.pdbx_netI_over_sigmaI_all _reflns_shell.pdbx_netI_over_sigmaI_obs _reflns_shell.pdbx_Rrim_I_all _reflns_shell.pdbx_Rpim_I_all _reflns_shell.pdbx_rejects _reflns_shell.pdbx_ordinal _reflns_shell.pdbx_diffrn_id _reflns_shell.pdbx_CC_half _reflns_shell.pdbx_R_split 2.400 2.490 ? ? ? ? ? 3398 ? 91.300 ? ? ? ? 0.701 ? ? ? ? ? ? ? ? 2.900 ? 1.081 ? ? ? ? ? 1 1 ? ? 2.490 2.590 ? ? ? ? ? 3508 ? 93.900 ? ? ? ? 0.559 ? ? ? ? ? ? ? ? 3.000 ? 1.087 ? ? ? ? ? 2 ? ? ? 2.590 2.700 ? ? ? ? ? 3573 ? 95.800 ? ? ? ? 0.429 ? ? ? ? ? ? ? ? 3.100 ? 1.122 ? ? ? ? ? 3 ? ? ? 2.700 2.850 ? ? ? ? ? 3628 ? 97.300 ? ? ? ? 0.313 ? ? ? ? ? ? ? ? 3.200 ? 1.089 ? ? ? ? ? 4 ? ? ? 2.850 3.020 ? ? ? ? ? 3684 ? 98.200 ? ? ? ? 0.226 ? ? ? ? ? ? ? ? 3.300 ? 1.037 ? ? ? ? ? 5 ? ? ? 3.020 3.260 ? ? ? ? ? 3693 ? 99.100 ? ? ? ? 0.166 ? ? ? ? ? ? ? ? 3.400 ? 1.096 ? ? ? ? ? 6 ? ? ? 3.260 3.580 ? ? ? ? ? 3748 ? 99.700 ? ? ? ? 0.119 ? ? ? ? ? ? ? ? 3.600 ? 1.097 ? ? ? ? ? 7 ? ? ? 3.580 4.100 ? ? ? ? ? 3775 ? 99.900 ? ? ? ? 0.088 ? ? ? ? ? ? ? ? 3.700 ? 1.075 ? ? ? ? ? 8 ? ? ? 4.100 5.170 ? 10.0 ? ? ? 3786 ? 99.900 ? ? ? ? 0.066 ? ? ? ? ? ? ? ? 3.700 ? 1.016 ? ? ? ? ? 9 ? ? ? 5.170 50.000 ? 10.0 ? ? ? 3885 ? 98.600 ? ? ? ? 0.047 ? ? ? ? ? ? ? ? 3.700 ? 1.022 ? ? ? ? ? 10 ? ? ? # _refine.aniso_B[1][1] 0.0000 _refine.aniso_B[1][2] 0.0000 _refine.aniso_B[1][3] 0.0000 _refine.aniso_B[2][2] 0.0000 _refine.aniso_B[2][3] 0.0000 _refine.aniso_B[3][3] 0.0000 _refine.B_iso_max 128.700 _refine.B_iso_mean 45.9629 _refine.B_iso_min 20.060 _refine.correlation_coeff_Fo_to_Fc 0.9403 _refine.correlation_coeff_Fo_to_Fc_free 0.9359 _refine.details ? _refine.diff_density_max ? _refine.diff_density_max_esd ? _refine.diff_density_min ? _refine.diff_density_min_esd ? _refine.diff_density_rms ? _refine.diff_density_rms_esd ? _refine.entry_id 4XX3 _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.ls_abs_structure_details ? _refine.ls_abs_structure_Flack ? _refine.ls_abs_structure_Flack_esd ? _refine.ls_abs_structure_Rogers ? _refine.ls_abs_structure_Rogers_esd ? _refine.ls_d_res_high 2.4000 _refine.ls_d_res_low 47.3400 _refine.ls_extinction_coef ? _refine.ls_extinction_coef_esd ? _refine.ls_extinction_expression ? _refine.ls_extinction_method ? _refine.ls_goodness_of_fit_all ? _refine.ls_goodness_of_fit_all_esd ? _refine.ls_goodness_of_fit_obs ? _refine.ls_goodness_of_fit_obs_esd ? _refine.ls_hydrogen_treatment ? _refine.ls_matrix_type ? _refine.ls_number_constraints ? _refine.ls_number_parameters ? _refine.ls_number_reflns_all ? _refine.ls_number_reflns_obs 36595 _refine.ls_number_reflns_R_free 1406 _refine.ls_number_reflns_R_work ? _refine.ls_number_restraints ? _refine.ls_percent_reflns_obs 97.4500 _refine.ls_percent_reflns_R_free 3.8400 _refine.ls_R_factor_all ? _refine.ls_R_factor_obs 0.2078 _refine.ls_R_factor_R_free 0.2243 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_R_factor_R_work 0.2071 _refine.ls_R_Fsqd_factor_obs ? _refine.ls_R_I_factor_obs ? _refine.ls_redundancy_reflns_all ? _refine.ls_redundancy_reflns_obs ? _refine.ls_restrained_S_all ? _refine.ls_restrained_S_obs ? _refine.ls_shift_over_esd_max ? _refine.ls_shift_over_esd_mean ? _refine.ls_structure_factor_coef ? _refine.ls_weighting_details ? _refine.ls_weighting_scheme ? _refine.ls_wR_factor_all ? _refine.ls_wR_factor_obs ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.occupancy_max 1.000 _refine.occupancy_min 0.500 _refine.solvent_model_details ? _refine.solvent_model_param_bsol ? _refine.solvent_model_param_ksol ? _refine.ls_R_factor_gt ? _refine.ls_goodness_of_fit_gt ? _refine.ls_goodness_of_fit_ref ? _refine.ls_shift_over_su_max ? _refine.ls_shift_over_su_max_lt ? _refine.ls_shift_over_su_mean ? _refine.ls_shift_over_su_mean_lt ? _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F 0.000 _refine.pdbx_ls_sigma_Fsqd ? _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_starting_model 'PDB entry 2I4Q' _refine.pdbx_stereochemistry_target_values ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_overall_ESU_R ? _refine.pdbx_overall_ESU_R_Free ? _refine.pdbx_solvent_vdw_probe_radii ? _refine.pdbx_solvent_ion_probe_radii ? _refine.pdbx_solvent_shrinkage_radii ? _refine.pdbx_real_space_R ? _refine.pdbx_density_correlation ? _refine.pdbx_pd_number_of_powder_patterns ? _refine.pdbx_pd_number_of_points ? _refine.pdbx_pd_meas_number_of_points ? _refine.pdbx_pd_proc_ls_prof_R_factor ? _refine.pdbx_pd_proc_ls_prof_wR_factor ? _refine.pdbx_pd_Marquardt_correlation_coeff ? _refine.pdbx_pd_Fsqrd_R_factor ? _refine.pdbx_pd_ls_matrix_band_width ? _refine.pdbx_overall_phase_error ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_diffrn_id 1 _refine.overall_SU_B ? _refine.overall_SU_ML ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_average_fsc_overall ? _refine.pdbx_average_fsc_work ? _refine.pdbx_average_fsc_free ? # _refine_analyze.entry_id 4XX3 _refine_analyze.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_analyze.Luzzati_coordinate_error_free ? _refine_analyze.Luzzati_coordinate_error_obs 0.332 _refine_analyze.Luzzati_d_res_low_free ? _refine_analyze.Luzzati_d_res_low_obs ? _refine_analyze.Luzzati_sigma_a_free ? _refine_analyze.Luzzati_sigma_a_free_details ? _refine_analyze.Luzzati_sigma_a_obs ? _refine_analyze.Luzzati_sigma_a_obs_details ? _refine_analyze.number_disordered_residues ? _refine_analyze.occupancy_sum_hydrogen ? _refine_analyze.occupancy_sum_non_hydrogen ? _refine_analyze.RG_d_res_high ? _refine_analyze.RG_d_res_low ? _refine_analyze.RG_free ? _refine_analyze.RG_work ? _refine_analyze.RG_free_work_ratio ? _refine_analyze.pdbx_Luzzati_d_res_high_obs ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 5116 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 86 _refine_hist.number_atoms_solvent 277 _refine_hist.number_atoms_total 5479 _refine_hist.d_res_high 2.4000 _refine_hist.d_res_low 47.3400 # loop_ _refine_ls_restr.pdbx_refine_id _refine_ls_restr.criterion _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.number _refine_ls_restr.rejects _refine_ls_restr.type _refine_ls_restr.weight _refine_ls_restr.pdbx_restraint_function 'X-RAY DIFFRACTION' ? ? ? 1730 ? t_dihedral_angle_d 2.000 SINUSOIDAL 'X-RAY DIFFRACTION' ? ? ? 108 ? t_trig_c_planes 2.000 HARMONIC 'X-RAY DIFFRACTION' ? ? ? 807 ? t_gen_planes 5.000 HARMONIC 'X-RAY DIFFRACTION' ? ? ? 5332 ? t_it 20.000 HARMONIC 'X-RAY DIFFRACTION' ? ? ? ? ? t_nbd ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? t_improper_torsion ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? t_pseud_angle ? ? 'X-RAY DIFFRACTION' ? ? ? 722 ? t_chiral_improper_torsion 5.000 SEMIHARMONIC 'X-RAY DIFFRACTION' ? ? ? ? ? t_sum_occupancies ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? t_utility_distance ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? t_utility_angle ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? t_utility_torsion ? ? 'X-RAY DIFFRACTION' ? ? ? 6127 ? t_ideal_dist_contact 4.000 SEMIHARMONIC 'X-RAY DIFFRACTION' ? 0.010 ? 5332 ? t_bond_d 2.000 HARMONIC 'X-RAY DIFFRACTION' ? 1.180 ? 7267 ? t_angle_deg 2.000 HARMONIC 'X-RAY DIFFRACTION' ? 3.670 ? ? ? t_omega_torsion ? ? 'X-RAY DIFFRACTION' ? 17.840 ? ? ? t_other_torsion ? ? # _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_ls_shell.d_res_high 2.4000 _refine_ls_shell.d_res_low 2.4700 _refine_ls_shell.number_reflns_all 2818 _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.number_reflns_R_free 110 _refine_ls_shell.number_reflns_R_work 2708 _refine_ls_shell.percent_reflns_obs 97.4500 _refine_ls_shell.percent_reflns_R_free 3.9000 _refine_ls_shell.R_factor_all 0.2391 _refine_ls_shell.R_factor_obs ? _refine_ls_shell.R_factor_R_free 0.2273 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.R_factor_R_work 0.2396 _refine_ls_shell.redundancy_reflns_all ? _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.wR_factor_all ? _refine_ls_shell.wR_factor_obs ? _refine_ls_shell.wR_factor_R_free ? _refine_ls_shell.wR_factor_R_work ? _refine_ls_shell.pdbx_total_number_of_bins_used 18 _refine_ls_shell.pdbx_phase_error ? _refine_ls_shell.pdbx_fsc_work ? _refine_ls_shell.pdbx_fsc_free ? # _struct.entry_id 4XX3 _struct.title 'Renin in complex with (S)-1-(3-(benzylcarbamoyl)benzyl)-4-isopropyl-4-methyl-6-oxotetrahydropyrimidin-2(1H)-iminium' _struct.pdbx_descriptor Renin _struct.pdbx_model_details ? _struct.pdbx_formula_weight ? _struct.pdbx_formula_weight_method ? _struct.pdbx_model_type_details ? _struct.pdbx_CASP_flag ? # _struct_keywords.entry_id 4XX3 _struct_keywords.text ;Animals, Antihypertensive Agents, Blood Pressure, Drug Design, Enzyme Inhibitors, Models, Molecular, Protein Conformation, Rats, Renin, Structure-Activity Relationship, Hydrolase-Hydrolase Inhibitor complex ; _struct_keywords.pdbx_keywords 'Hydrolase/Hydrolase Inhibitor' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 1 ? C N N 2 ? D N N 3 ? E N N 2 ? F N N 3 ? G N N 4 ? H N N 4 ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 AA1 TYR A 55 ? TYR A 60 ? TYR A 121 TYR A 126 1 ? 6 HELX_P HELX_P2 AA2 ASP A 65 ? SER A 69 ? ASP A 131 SER A 135 5 ? 5 HELX_P HELX_P3 AA3 PRO A 115 ? MET A 120 ? PRO A 181 MET A 186 1 ? 6 HELX_P HELX_P4 AA4 PHE A 132 ? VAL A 140 ? PHE A 198 VAL A 206 5 ? 9 HELX_P HELX_P5 AA5 PRO A 142 ? GLN A 150 ? PRO A 208 GLN A 216 1 ? 9 HELX_P HELX_P6 AA6 ASP A 182 ? GLN A 184 ? ASP A 248 GLN A 250 5 ? 3 HELX_P HELX_P7 AA7 SER A 235 ? GLY A 247 ? SER A 301 GLY A 313 1 ? 13 HELX_P HELX_P8 AA8 ASN A 260 ? LEU A 265 ? ASN A 326 LEU A 331 5 ? 6 HELX_P HELX_P9 AA9 THR A 280 ? VAL A 285 ? THR A 346 VAL A 351 1 ? 6 HELX_P HELX_P10 AB1 GLY A 316 ? LYS A 322 ? GLY A 382 LYS A 388 1 ? 7 HELX_P HELX_P11 AB2 TYR B 55 ? HIS B 61 ? TYR B 121 HIS B 127 1 ? 7 HELX_P HELX_P12 AB3 ASP B 65 ? SER B 69 ? ASP B 131 SER B 135 5 ? 5 HELX_P HELX_P13 AB4 PRO B 115 ? MET B 120 ? PRO B 181 MET B 186 1 ? 6 HELX_P HELX_P14 AB5 PHE B 132 ? VAL B 140 ? PHE B 198 VAL B 206 5 ? 9 HELX_P HELX_P15 AB6 PRO B 142 ? GLN B 150 ? PRO B 208 GLN B 216 1 ? 9 HELX_P HELX_P16 AB7 ASP B 182 ? GLN B 184 ? ASP B 248 GLN B 250 5 ? 3 HELX_P HELX_P17 AB8 SER B 235 ? GLY B 247 ? SER B 301 GLY B 313 1 ? 13 HELX_P HELX_P18 AB9 ASN B 260 ? LEU B 265 ? ASN B 326 LEU B 331 5 ? 6 HELX_P HELX_P19 AC1 THR B 280 ? VAL B 285 ? THR B 346 VAL B 351 1 ? 6 HELX_P HELX_P20 AC2 GLY B 316 ? LYS B 322 ? GLY B 382 LYS B 388 1 ? 7 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 51 SG ? ? ? 1_555 A CYS 58 SG ? ? A CYS 117 A CYS 124 1_555 ? ? ? ? ? ? ? 2.008 ? disulf2 disulf ? ? A CYS 217 SG ? ? ? 1_555 A CYS 221 SG ? ? A CYS 283 A CYS 287 1_555 ? ? ? ? ? ? ? 2.035 ? disulf3 disulf ? ? A CYS 259 SG ? ? ? 1_555 A CYS 296 SG ? ? A CYS 325 A CYS 362 1_555 ? ? ? ? ? ? ? 2.031 ? disulf4 disulf ? ? B CYS 51 SG ? ? ? 1_555 B CYS 58 SG ? ? B CYS 117 B CYS 124 1_555 ? ? ? ? ? ? ? 2.024 ? disulf5 disulf ? ? B CYS 217 SG ? ? ? 1_555 B CYS 221 SG ? ? B CYS 283 B CYS 287 1_555 ? ? ? ? ? ? ? 2.040 ? disulf6 disulf ? ? B CYS 259 SG ? ? ? 1_555 B CYS 296 SG ? ? B CYS 325 B CYS 362 1_555 ? ? ? ? ? ? ? 2.042 ? covale1 covale one ? A ASN 75 ND2 ? ? ? 1_555 C NAG . C1 ? ? A ASN 141 A NAG 501 1_555 ? ? ? ? ? ? ? 1.434 ? covale2 covale one ? B ASN 75 ND2 ? ? ? 1_555 E NAG . C1 ? ? B ASN 141 B NAG 501 1_555 ? ? ? ? ? ? ? 1.434 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 THR 28 A . ? THR 94 A PRO 29 A ? PRO 95 A 1 -3.50 2 LEU 117 A . ? LEU 183 A PRO 118 A ? PRO 184 A 1 10.55 3 PRO 307 A . ? PRO 373 A PRO 308 A ? PRO 374 A 1 2.67 4 GLY 310 A . ? GLY 376 A PRO 311 A ? PRO 377 A 1 -2.69 5 THR 28 B . ? THR 94 B PRO 29 B ? PRO 95 B 1 -3.70 6 LEU 117 B . ? LEU 183 B PRO 118 B ? PRO 184 B 1 9.46 7 PRO 307 B . ? PRO 373 B PRO 308 B ? PRO 374 B 1 2.93 8 GLY 310 B . ? GLY 376 B PRO 311 B ? PRO 377 B 1 -2.84 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details AA1 ? 9 ? AA2 ? 13 ? AA3 ? 4 ? AA4 ? 4 ? AA5 ? 2 ? AA6 ? 3 ? AA7 ? 9 ? AA8 ? 13 ? AA9 ? 5 ? AB1 ? 4 ? AB2 ? 3 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense AA1 1 2 ? anti-parallel AA1 2 3 ? anti-parallel AA1 3 4 ? anti-parallel AA1 4 5 ? anti-parallel AA1 5 6 ? anti-parallel AA1 6 7 ? anti-parallel AA1 7 8 ? anti-parallel AA1 8 9 ? anti-parallel AA2 1 2 ? anti-parallel AA2 2 3 ? anti-parallel AA2 3 4 ? parallel AA2 4 5 ? anti-parallel AA2 5 6 ? parallel AA2 6 7 ? anti-parallel AA2 7 8 ? anti-parallel AA2 8 9 ? anti-parallel AA2 9 10 ? anti-parallel AA2 10 11 ? anti-parallel AA2 11 12 ? anti-parallel AA2 12 13 ? anti-parallel AA3 1 2 ? anti-parallel AA3 2 3 ? anti-parallel AA3 3 4 ? anti-parallel AA4 1 2 ? anti-parallel AA4 2 3 ? anti-parallel AA4 3 4 ? parallel AA5 1 2 ? parallel AA6 1 2 ? anti-parallel AA6 2 3 ? anti-parallel AA7 1 2 ? anti-parallel AA7 2 3 ? anti-parallel AA7 3 4 ? anti-parallel AA7 4 5 ? anti-parallel AA7 5 6 ? anti-parallel AA7 6 7 ? anti-parallel AA7 7 8 ? anti-parallel AA7 8 9 ? anti-parallel AA8 1 2 ? anti-parallel AA8 2 3 ? anti-parallel AA8 3 4 ? parallel AA8 4 5 ? anti-parallel AA8 5 6 ? parallel AA8 6 7 ? anti-parallel AA8 7 8 ? anti-parallel AA8 8 9 ? anti-parallel AA8 9 10 ? anti-parallel AA8 10 11 ? anti-parallel AA8 11 12 ? anti-parallel AA8 12 13 ? anti-parallel AA9 1 2 ? anti-parallel AA9 2 3 ? parallel AA9 3 4 ? anti-parallel AA9 4 5 ? parallel AB1 1 2 ? anti-parallel AB1 2 3 ? anti-parallel AB1 3 4 ? anti-parallel AB2 1 2 ? anti-parallel AB2 2 3 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id AA1 1 LYS A 73 ? ARG A 82 ? LYS A 139 ARG A 148 AA1 2 THR A 87 ? VAL A 99 ? THR A 153 VAL A 165 AA1 3 GLN A 19 ? ILE A 26 ? GLN A 85 ILE A 92 AA1 4 SER A 8 ? TYR A 15 ? SER A 74 TYR A 81 AA1 5 GLY A 174 ? LEU A 178 ? GLY A 240 LEU A 244 AA1 6 VAL A 157 ? TYR A 162 ? VAL A 223 TYR A 228 AA1 7 PHE A 323 ? ASP A 328 ? PHE A 389 ASP A 394 AA1 8 ARG A 333 ? ALA A 339 ? ARG A 399 ALA A 405 AA1 9 TYR A 186 ? ASN A 194 ? TYR A 252 ASN A 260 AA2 1 LYS A 73 ? ARG A 82 ? LYS A 139 ARG A 148 AA2 2 THR A 87 ? VAL A 99 ? THR A 153 VAL A 165 AA2 3 ILE A 102 ? GLU A 113 ? ILE A 168 GLU A 179 AA2 4 VAL A 44 ? PRO A 47 ? VAL A 110 PRO A 113 AA2 5 GLY A 126 ? GLY A 129 ? GLY A 192 GLY A 195 AA2 6 GLN A 31 ? ASP A 38 ? GLN A 97 ASP A 104 AA2 7 GLN A 19 ? ILE A 26 ? GLN A 85 ILE A 92 AA2 8 SER A 8 ? TYR A 15 ? SER A 74 TYR A 81 AA2 9 GLY A 174 ? LEU A 178 ? GLY A 240 LEU A 244 AA2 10 VAL A 157 ? TYR A 162 ? VAL A 223 TYR A 228 AA2 11 PHE A 323 ? ASP A 328 ? PHE A 389 ASP A 394 AA2 12 ARG A 333 ? ALA A 339 ? ARG A 399 ALA A 405 AA2 13 TYR A 186 ? ASN A 194 ? TYR A 252 ASN A 260 AA3 1 THR A 214 ? LEU A 216 ? THR A 280 LEU A 282 AA3 2 GLN A 202 ? VAL A 210 ? GLN A 268 VAL A 276 AA3 3 ILE A 268 ? LEU A 272 ? ILE A 334 LEU A 338 AA3 4 LYS A 275 ? LEU A 279 ? LYS A 341 LEU A 345 AA4 1 THR A 214 ? LEU A 216 ? THR A 280 LEU A 282 AA4 2 GLN A 202 ? VAL A 210 ? GLN A 268 VAL A 276 AA4 3 CYS A 221 ? VAL A 225 ? CYS A 287 VAL A 291 AA4 4 TRP A 313 ? LEU A 315 ? TRP A 379 LEU A 381 AA5 1 ILE A 232 ? GLY A 234 ? ILE A 298 GLY A 300 AA5 2 ILE A 300 ? ALA A 302 ? ILE A 366 ALA A 368 AA6 1 LYS A 249 ? LYS A 250 ? LYS A 315 LYS A 316 AA6 2 TYR A 255 ? LYS A 258 ? TYR A 321 LYS A 324 AA6 3 LEU A 295 ? THR A 297 ? LEU A 361 THR A 363 AA7 1 LYS B 73 ? ARG B 82 ? LYS B 139 ARG B 148 AA7 2 THR B 87 ? VAL B 99 ? THR B 153 VAL B 165 AA7 3 GLN B 19 ? ILE B 26 ? GLN B 85 ILE B 92 AA7 4 SER B 8 ? TYR B 15 ? SER B 74 TYR B 81 AA7 5 GLY B 174 ? LEU B 178 ? GLY B 240 LEU B 244 AA7 6 VAL B 157 ? TYR B 162 ? VAL B 223 TYR B 228 AA7 7 PHE B 323 ? ASP B 328 ? PHE B 389 ASP B 394 AA7 8 ARG B 333 ? ALA B 339 ? ARG B 399 ALA B 405 AA7 9 TYR B 186 ? ASN B 194 ? TYR B 252 ASN B 260 AA8 1 LYS B 73 ? ARG B 82 ? LYS B 139 ARG B 148 AA8 2 THR B 87 ? VAL B 99 ? THR B 153 VAL B 165 AA8 3 ILE B 102 ? GLU B 113 ? ILE B 168 GLU B 179 AA8 4 VAL B 44 ? PRO B 47 ? VAL B 110 PRO B 113 AA8 5 GLY B 126 ? GLY B 129 ? GLY B 192 GLY B 195 AA8 6 GLN B 31 ? ASP B 38 ? GLN B 97 ASP B 104 AA8 7 GLN B 19 ? ILE B 26 ? GLN B 85 ILE B 92 AA8 8 SER B 8 ? TYR B 15 ? SER B 74 TYR B 81 AA8 9 GLY B 174 ? LEU B 178 ? GLY B 240 LEU B 244 AA8 10 VAL B 157 ? TYR B 162 ? VAL B 223 TYR B 228 AA8 11 PHE B 323 ? ASP B 328 ? PHE B 389 ASP B 394 AA8 12 ARG B 333 ? ALA B 339 ? ARG B 399 ALA B 405 AA8 13 TYR B 186 ? ASN B 194 ? TYR B 252 ASN B 260 AA9 1 GLN B 202 ? MET B 205 ? GLN B 268 MET B 271 AA9 2 CYS B 221 ? VAL B 225 ? CYS B 287 VAL B 291 AA9 3 TRP B 313 ? LEU B 315 ? TRP B 379 LEU B 381 AA9 4 ILE B 232 ? GLY B 234 ? ILE B 298 GLY B 300 AA9 5 ILE B 300 ? ALA B 302 ? ILE B 366 ALA B 368 AB1 1 LEU B 215 ? LEU B 216 ? LEU B 281 LEU B 282 AB1 2 GLY B 207 ? VAL B 210 ? GLY B 273 VAL B 276 AB1 3 ILE B 268 ? LEU B 272 ? ILE B 334 LEU B 338 AB1 4 LYS B 275 ? LEU B 279 ? LYS B 341 LEU B 345 AB2 1 LYS B 249 ? LYS B 250 ? LYS B 315 LYS B 316 AB2 2 TYR B 255 ? LYS B 258 ? TYR B 321 LYS B 324 AB2 3 LEU B 295 ? THR B 297 ? LEU B 361 THR B 363 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id AA1 1 2 N GLY A 76 ? N GLY A 142 O LEU A 92 ? O LEU A 158 AA1 2 3 O THR A 98 ? O THR A 164 N GLY A 25 ? N GLY A 91 AA1 3 4 O GLN A 19 ? O GLN A 85 N TYR A 15 ? N TYR A 81 AA1 4 5 N SER A 8 ? N SER A 74 O LEU A 178 ? O LEU A 244 AA1 5 6 O VAL A 177 ? O VAL A 243 N SER A 159 ? N SER A 225 AA1 6 7 N PHE A 158 ? N PHE A 224 O PHE A 327 ? O PHE A 393 AA1 7 8 N GLU A 326 ? N GLU A 392 O GLY A 335 ? O GLY A 401 AA1 8 9 O ILE A 334 ? O ILE A 400 N ILE A 193 ? N ILE A 259 AA2 1 2 N GLY A 76 ? N GLY A 142 O LEU A 92 ? O LEU A 158 AA2 2 3 N PHE A 91 ? N PHE A 157 O GLU A 110 ? O GLU A 176 AA2 3 4 O GLY A 109 ? O GLY A 175 N VAL A 44 ? N VAL A 110 AA2 4 5 N TRP A 45 ? N TRP A 111 O VAL A 127 ? O VAL A 193 AA2 5 6 O VAL A 128 ? O VAL A 194 N VAL A 36 ? N VAL A 102 AA2 6 7 O VAL A 35 ? O VAL A 101 N GLY A 22 ? N GLY A 88 AA2 7 8 O GLN A 19 ? O GLN A 85 N TYR A 15 ? N TYR A 81 AA2 8 9 N SER A 8 ? N SER A 74 O LEU A 178 ? O LEU A 244 AA2 9 10 O VAL A 177 ? O VAL A 243 N SER A 159 ? N SER A 225 AA2 10 11 N PHE A 158 ? N PHE A 224 O PHE A 327 ? O PHE A 393 AA2 11 12 N GLU A 326 ? N GLU A 392 O GLY A 335 ? O GLY A 401 AA2 12 13 O ILE A 334 ? O ILE A 400 N ILE A 193 ? N ILE A 259 AA3 1 2 O LEU A 216 ? O LEU A 282 N VAL A 208 ? N VAL A 274 AA3 2 3 N GLY A 207 ? N GLY A 273 O HIS A 271 ? O HIS A 337 AA3 3 4 N ILE A 268 ? N ILE A 334 O LEU A 279 ? O LEU A 345 AA4 1 2 O LEU A 216 ? O LEU A 282 N VAL A 208 ? N VAL A 274 AA4 2 3 N MET A 205 ? N MET A 271 O CYS A 221 ? O CYS A 287 AA4 3 4 N LEU A 224 ? N LEU A 290 O LEU A 315 ? O LEU A 381 AA5 1 2 N ILE A 232 ? N ILE A 298 O HIS A 301 ? O HIS A 367 AA6 1 2 N LYS A 249 ? N LYS A 315 O VAL A 256 ? O VAL A 322 AA6 2 3 N VAL A 257 ? N VAL A 323 O CYS A 296 ? O CYS A 362 AA7 1 2 N LEU B 81 ? N LEU B 147 O VAL B 88 ? O VAL B 154 AA7 2 3 O THR B 98 ? O THR B 164 N GLY B 25 ? N GLY B 91 AA7 3 4 O GLN B 19 ? O GLN B 85 N TYR B 15 ? N TYR B 81 AA7 4 5 N SER B 8 ? N SER B 74 O LEU B 178 ? O LEU B 244 AA7 5 6 O VAL B 177 ? O VAL B 243 N SER B 159 ? N SER B 225 AA7 6 7 N PHE B 158 ? N PHE B 224 O PHE B 327 ? O PHE B 393 AA7 7 8 N GLU B 326 ? N GLU B 392 O GLY B 335 ? O GLY B 401 AA7 8 9 O LEU B 338 ? O LEU B 404 N GLU B 187 ? N GLU B 253 AA8 1 2 N LEU B 81 ? N LEU B 147 O VAL B 88 ? O VAL B 154 AA8 2 3 N PHE B 91 ? N PHE B 157 O GLU B 110 ? O GLU B 176 AA8 3 4 O GLY B 109 ? O GLY B 175 N VAL B 44 ? N VAL B 110 AA8 4 5 N TRP B 45 ? N TRP B 111 O VAL B 127 ? O VAL B 193 AA8 5 6 O VAL B 128 ? O VAL B 194 N VAL B 36 ? N VAL B 102 AA8 6 7 O VAL B 35 ? O VAL B 101 N GLY B 22 ? N GLY B 88 AA8 7 8 O GLN B 19 ? O GLN B 85 N TYR B 15 ? N TYR B 81 AA8 8 9 N SER B 8 ? N SER B 74 O LEU B 178 ? O LEU B 244 AA8 9 10 O VAL B 177 ? O VAL B 243 N SER B 159 ? N SER B 225 AA8 10 11 N PHE B 158 ? N PHE B 224 O PHE B 327 ? O PHE B 393 AA8 11 12 N GLU B 326 ? N GLU B 392 O GLY B 335 ? O GLY B 401 AA8 12 13 O LEU B 338 ? O LEU B 404 N GLU B 187 ? N GLU B 253 AA9 1 2 N MET B 205 ? N MET B 271 O CYS B 221 ? O CYS B 287 AA9 2 3 N LEU B 224 ? N LEU B 290 O LEU B 315 ? O LEU B 381 AA9 3 4 O ALA B 314 ? O ALA B 380 N SER B 233 ? N SER B 299 AA9 4 5 N ILE B 232 ? N ILE B 298 O HIS B 301 ? O HIS B 367 AB1 1 2 O LEU B 216 ? O LEU B 282 N VAL B 208 ? N VAL B 274 AB1 2 3 N GLY B 207 ? N GLY B 273 O HIS B 271 ? O HIS B 337 AB1 3 4 N ILE B 268 ? N ILE B 334 O LEU B 279 ? O LEU B 345 AB2 1 2 N LYS B 249 ? N LYS B 315 O VAL B 256 ? O VAL B 322 AB2 2 3 N VAL B 257 ? N VAL B 323 O CYS B 296 ? O CYS B 362 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software A 70X 502 ? 14 'binding site for residue 70X A 502' AC2 Software B 70X 502 ? 14 'binding site for residue 70X B 502' AC3 Software A NAG 501 ? 2 'binding site for Mono-Saccharide NAG A 501 bound to ASN A 141' AC4 Software B NAG 501 ? 1 'binding site for Mono-Saccharide NAG B 501 bound to ASN B 141' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 14 THR A 18 ? THR A 84 . ? 1_555 ? 2 AC1 14 GLN A 19 ? GLN A 85 . ? 1_555 ? 3 AC1 14 TYR A 20 ? TYR A 86 . ? 1_555 ? 4 AC1 14 VAL A 36 ? VAL A 102 . ? 1_555 ? 5 AC1 14 ASP A 38 ? ASP A 104 . ? 1_555 ? 6 AC1 14 TYR A 83 ? TYR A 149 . ? 1_555 ? 7 AC1 14 SER A 84 ? SER A 150 . ? 1_555 ? 8 AC1 14 THR A 85 ? THR A 151 . ? 1_555 ? 9 AC1 14 ASP A 226 ? ASP A 292 . ? 1_555 ? 10 AC1 14 THR A 227 ? THR A 293 . ? 1_555 ? 11 AC1 14 GLY A 228 ? GLY A 294 . ? 1_555 ? 12 AC1 14 ALA A 229 ? ALA A 295 . ? 1_555 ? 13 AC1 14 SER A 230 ? SER A 296 . ? 1_555 ? 14 AC1 14 HOH G . ? HOH A 653 . ? 1_555 ? 15 AC2 14 THR B 18 ? THR B 84 . ? 1_555 ? 16 AC2 14 GLN B 19 ? GLN B 85 . ? 1_555 ? 17 AC2 14 TYR B 20 ? TYR B 86 . ? 1_555 ? 18 AC2 14 VAL B 36 ? VAL B 102 . ? 1_555 ? 19 AC2 14 ASP B 38 ? ASP B 104 . ? 1_555 ? 20 AC2 14 TYR B 83 ? TYR B 149 . ? 1_555 ? 21 AC2 14 SER B 84 ? SER B 150 . ? 1_555 ? 22 AC2 14 THR B 85 ? THR B 151 . ? 1_555 ? 23 AC2 14 ASP B 226 ? ASP B 292 . ? 1_555 ? 24 AC2 14 THR B 227 ? THR B 293 . ? 1_555 ? 25 AC2 14 GLY B 228 ? GLY B 294 . ? 1_555 ? 26 AC2 14 ALA B 229 ? ALA B 295 . ? 1_555 ? 27 AC2 14 SER B 230 ? SER B 296 . ? 1_555 ? 28 AC2 14 HOH H . ? HOH B 651 . ? 1_555 ? 29 AC3 2 ASN A 75 ? ASN A 141 . ? 1_555 ? 30 AC3 2 HOH G . ? HOH A 607 . ? 1_555 ? 31 AC4 1 ASN B 75 ? ASN B 141 . ? 1_555 ? # _atom_sites.entry_id 4XX3 _atom_sites.fract_transf_matrix[1][1] 0.007041 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.007041 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.007041 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . THR A 1 2 ? 5.893 70.455 44.957 1.00 89.03 ? 68 THR A N 1 ATOM 2 C CA . THR A 1 2 ? 5.198 70.728 46.214 1.00 88.68 ? 68 THR A CA 1 ATOM 3 C C . THR A 1 2 ? 6.212 70.962 47.345 1.00 90.48 ? 68 THR A C 1 ATOM 4 O O . THR A 1 2 ? 7.222 70.250 47.440 1.00 90.54 ? 68 THR A O 1 ATOM 5 C CB . THR A 1 2 ? 4.144 69.632 46.500 1.00 101.40 ? 68 THR A CB 1 ATOM 6 O OG1 . THR A 1 2 ? 3.284 69.523 45.358 1.00 105.89 ? 68 THR A OG1 1 ATOM 7 C CG2 . THR A 1 2 ? 3.291 69.919 47.748 1.00 98.33 ? 68 THR A CG2 1 ATOM 8 N N . LEU A 1 3 ? 5.950 71.997 48.171 1.00 84.15 ? 69 LEU A N 1 ATOM 9 C CA . LEU A 1 3 ? 6.797 72.375 49.303 1.00 82.25 ? 69 LEU A CA 1 ATOM 10 C C . LEU A 1 3 ? 6.047 72.266 50.637 1.00 82.48 ? 69 LEU A C 1 ATOM 11 O O . LEU A 1 3 ? 4.878 72.657 50.735 1.00 81.84 ? 69 LEU A O 1 ATOM 12 C CB . LEU A 1 3 ? 7.407 73.791 49.122 1.00 81.98 ? 69 LEU A CB 1 ATOM 13 C CG . LEU A 1 3 ? 8.440 74.002 47.979 1.00 85.93 ? 69 LEU A CG 1 ATOM 14 C CD1 . LEU A 1 3 ? 8.837 75.461 47.865 1.00 85.94 ? 69 LEU A CD1 1 ATOM 15 C CD2 . LEU A 1 3 ? 9.695 73.157 48.174 1.00 86.77 ? 69 LEU A CD2 1 ATOM 16 N N . GLY A 1 4 ? 6.735 71.707 51.634 1.00 75.31 ? 70 GLY A N 1 ATOM 17 C CA . GLY A 1 4 ? 6.245 71.544 52.998 1.00 72.78 ? 70 GLY A CA 1 ATOM 18 C C . GLY A 1 4 ? 6.973 72.506 53.912 1.00 71.21 ? 70 GLY A C 1 ATOM 19 O O . GLY A 1 4 ? 7.248 73.642 53.507 1.00 69.86 ? 70 GLY A O 1 ATOM 20 N N . ASN A 1 5 ? 7.361 72.042 55.122 1.00 65.61 ? 71 ASN A N 1 ATOM 21 C CA . ASN A 1 5 ? 8.110 72.857 56.094 1.00 65.08 ? 71 ASN A CA 1 ATOM 22 C C . ASN A 1 5 ? 9.283 72.099 56.780 1.00 66.87 ? 71 ASN A C 1 ATOM 23 O O . ASN A 1 5 ? 9.962 72.660 57.647 1.00 66.73 ? 71 ASN A O 1 ATOM 24 C CB . ASN A 1 5 ? 7.158 73.480 57.130 1.00 70.33 ? 71 ASN A CB 1 ATOM 25 C CG . ASN A 1 5 ? 7.487 74.915 57.513 1.00 104.81 ? 71 ASN A CG 1 ATOM 26 O OD1 . ASN A 1 5 ? 8.005 75.188 58.610 1.00 99.78 ? 71 ASN A OD1 1 ATOM 27 N ND2 . ASN A 1 5 ? 7.153 75.870 56.637 1.00 97.30 ? 71 ASN A ND2 1 ATOM 28 N N . THR A 1 6 ? 9.543 70.849 56.355 1.00 61.48 ? 72 THR A N 1 ATOM 29 C CA . THR A 1 6 ? 10.607 69.978 56.868 1.00 59.94 ? 72 THR A CA 1 ATOM 30 C C . THR A 1 6 ? 12.010 70.362 56.338 1.00 61.10 ? 72 THR A C 1 ATOM 31 O O . THR A 1 6 ? 12.215 70.621 55.151 1.00 60.20 ? 72 THR A O 1 ATOM 32 C CB . THR A 1 6 ? 10.246 68.493 56.590 1.00 69.22 ? 72 THR A CB 1 ATOM 33 O OG1 . THR A 1 6 ? 8.993 68.199 57.212 1.00 77.62 ? 72 THR A OG1 1 ATOM 34 C CG2 . THR A 1 6 ? 11.300 67.490 57.078 1.00 65.40 ? 72 THR A CG2 1 ATOM 35 N N . THR A 1 7 ? 12.955 70.409 57.265 1.00 55.75 ? 73 THR A N 1 ATOM 36 C CA . THR A 1 7 ? 14.379 70.570 57.063 1.00 54.26 ? 73 THR A CA 1 ATOM 37 C C . THR A 1 7 ? 14.929 69.337 57.771 1.00 56.09 ? 73 THR A C 1 ATOM 38 O O . THR A 1 7 ? 14.515 69.061 58.900 1.00 55.97 ? 73 THR A O 1 ATOM 39 C CB . THR A 1 7 ? 14.853 71.930 57.582 1.00 60.39 ? 73 THR A CB 1 ATOM 40 O OG1 . THR A 1 7 ? 15.266 72.705 56.455 1.00 64.15 ? 73 THR A OG1 1 ATOM 41 C CG2 . THR A 1 7 ? 16.002 71.835 58.600 1.00 56.91 ? 73 THR A CG2 1 ATOM 42 N N . SER A 1 8 ? 15.743 68.533 57.082 1.00 50.43 ? 74 SER A N 1 ATOM 43 C CA . SER A 1 8 ? 16.282 67.325 57.690 1.00 49.17 ? 74 SER A CA 1 ATOM 44 C C . SER A 1 8 ? 17.808 67.390 57.619 1.00 50.73 ? 74 SER A C 1 ATOM 45 O O . SER A 1 8 ? 18.368 67.678 56.568 1.00 50.50 ? 74 SER A O 1 ATOM 46 C CB . SER A 1 8 ? 15.713 66.081 57.009 1.00 53.38 ? 74 SER A CB 1 ATOM 47 O OG . SER A 1 8 ? 16.359 64.903 57.452 1.00 66.78 ? 74 SER A OG 1 ATOM 48 N N . SER A 1 9 ? 18.475 67.200 58.741 1.00 45.90 ? 75 SER A N 1 ATOM 49 C CA . SER A 1 9 ? 19.927 67.271 58.770 1.00 44.74 ? 75 SER A CA 1 ATOM 50 C C . SER A 1 9 ? 20.577 65.929 59.095 1.00 46.52 ? 75 SER A C 1 ATOM 51 O O . SER A 1 9 ? 20.076 65.166 59.931 1.00 48.25 ? 75 SER A O 1 ATOM 52 C CB . SER A 1 9 ? 20.407 68.383 59.698 1.00 47.76 ? 75 SER A CB 1 ATOM 53 O OG . SER A 1 9 ? 20.384 67.963 61.048 1.00 55.82 ? 75 SER A OG 1 ATOM 54 N N . VAL A 1 10 ? 21.657 65.618 58.377 1.00 38.45 ? 76 VAL A N 1 ATOM 55 C CA . VAL A 1 10 ? 22.418 64.386 58.588 1.00 35.69 ? 76 VAL A CA 1 ATOM 56 C C . VAL A 1 10 ? 23.834 64.795 59.051 1.00 35.35 ? 76 VAL A C 1 ATOM 57 O O . VAL A 1 10 ? 24.473 65.615 58.390 1.00 31.51 ? 76 VAL A O 1 ATOM 58 C CB . VAL A 1 10 ? 22.467 63.475 57.341 1.00 39.14 ? 76 VAL A CB 1 ATOM 59 C CG1 . VAL A 1 10 ? 23.075 62.124 57.686 1.00 39.07 ? 76 VAL A CG1 1 ATOM 60 C CG2 . VAL A 1 10 ? 21.092 63.305 56.696 1.00 39.10 ? 76 VAL A CG2 1 ATOM 61 N N . ILE A 1 11 ? 24.275 64.275 60.211 1.00 32.58 ? 77 ILE A N 1 ATOM 62 C CA . ILE A 1 11 ? 25.605 64.520 60.772 1.00 33.29 ? 77 ILE A CA 1 ATOM 63 C C . ILE A 1 11 ? 26.627 63.671 59.990 1.00 33.98 ? 77 ILE A C 1 ATOM 64 O O . ILE A 1 11 ? 26.422 62.466 59.784 1.00 33.36 ? 77 ILE A O 1 ATOM 65 C CB . ILE A 1 11 ? 25.656 64.237 62.312 1.00 37.49 ? 77 ILE A CB 1 ATOM 66 C CG1 . ILE A 1 11 ? 24.691 65.154 63.134 1.00 39.39 ? 77 ILE A CG1 1 ATOM 67 C CG2 . ILE A 1 11 ? 27.083 64.291 62.875 1.00 37.20 ? 77 ILE A CG2 1 ATOM 68 C CD1 . ILE A 1 11 ? 24.680 66.727 62.762 1.00 59.58 ? 77 ILE A CD1 1 ATOM 69 N N . LEU A 1 12 ? 27.726 64.302 59.569 1.00 27.21 ? 78 LEU A N 1 ATOM 70 C CA . LEU A 1 12 ? 28.767 63.595 58.827 1.00 26.12 ? 78 LEU A CA 1 ATOM 71 C C . LEU A 1 12 ? 29.996 63.406 59.672 1.00 30.71 ? 78 LEU A C 1 ATOM 72 O O . LEU A 1 12 ? 30.279 64.211 60.553 1.00 30.72 ? 78 LEU A O 1 ATOM 73 C CB . LEU A 1 12 ? 29.142 64.330 57.504 1.00 25.06 ? 78 LEU A CB 1 ATOM 74 C CG . LEU A 1 12 ? 27.996 64.770 56.577 1.00 25.84 ? 78 LEU A CG 1 ATOM 75 C CD1 . LEU A 1 12 ? 28.548 65.489 55.362 1.00 25.70 ? 78 LEU A CD1 1 ATOM 76 C CD2 . LEU A 1 12 ? 27.104 63.576 56.154 1.00 20.06 ? 78 LEU A CD2 1 ATOM 77 N N . THR A 1 13 ? 30.735 62.345 59.385 1.00 27.82 ? 79 THR A N 1 ATOM 78 C CA . THR A 1 13 ? 31.998 61.999 60.021 1.00 26.69 ? 79 THR A CA 1 ATOM 79 C C . THR A 1 13 ? 33.094 62.452 59.062 1.00 31.27 ? 79 THR A C 1 ATOM 80 O O . THR A 1 13 ? 32.996 62.237 57.862 1.00 30.45 ? 79 THR A O 1 ATOM 81 C CB . THR A 1 13 ? 32.036 60.483 60.285 1.00 31.02 ? 79 THR A CB 1 ATOM 82 O OG1 . THR A 1 13 ? 31.060 60.196 61.268 1.00 31.32 ? 79 THR A OG1 1 ATOM 83 C CG2 . THR A 1 13 ? 33.406 59.984 60.763 1.00 29.08 ? 79 THR A CG2 1 ATOM 84 N N . ASN A 1 14 ? 34.105 63.112 59.589 1.00 29.93 ? 80 ASN A N 1 ATOM 85 C CA . ASN A 1 14 ? 35.223 63.536 58.791 1.00 29.85 ? 80 ASN A CA 1 ATOM 86 C C . ASN A 1 14 ? 36.362 62.549 59.028 1.00 34.71 ? 80 ASN A C 1 ATOM 87 O O . ASN A 1 14 ? 36.948 62.512 60.112 1.00 33.71 ? 80 ASN A O 1 ATOM 88 C CB . ASN A 1 14 ? 35.662 64.979 59.147 1.00 27.49 ? 80 ASN A CB 1 ATOM 89 C CG . ASN A 1 14 ? 36.930 65.421 58.461 1.00 37.72 ? 80 ASN A CG 1 ATOM 90 O OD1 . ASN A 1 14 ? 37.557 64.684 57.682 1.00 33.00 ? 80 ASN A OD1 1 ATOM 91 N ND2 . ASN A 1 14 ? 37.322 66.653 58.699 1.00 24.72 ? 80 ASN A ND2 1 ATOM 92 N N . TYR A 1 15 ? 36.695 61.783 57.993 1.00 34.08 ? 81 TYR A N 1 ATOM 93 C CA . TYR A 1 15 ? 37.825 60.883 58.002 1.00 34.76 ? 81 TYR A CA 1 ATOM 94 C C . TYR A 1 15 ? 39.016 61.546 57.292 1.00 37.57 ? 81 TYR A C 1 ATOM 95 O O . TYR A 1 15 ? 39.003 61.675 56.061 1.00 34.71 ? 81 TYR A O 1 ATOM 96 C CB . TYR A 1 15 ? 37.483 59.545 57.326 1.00 38.00 ? 81 TYR A CB 1 ATOM 97 C CG . TYR A 1 15 ? 38.684 58.618 57.259 1.00 42.05 ? 81 TYR A CG 1 ATOM 98 C CD1 . TYR A 1 15 ? 39.202 58.028 58.409 1.00 44.68 ? 81 TYR A CD1 1 ATOM 99 C CD2 . TYR A 1 15 ? 39.340 58.379 56.053 1.00 43.74 ? 81 TYR A CD2 1 ATOM 100 C CE1 . TYR A 1 15 ? 40.320 57.189 58.355 1.00 47.82 ? 81 TYR A CE1 1 ATOM 101 C CE2 . TYR A 1 15 ? 40.458 57.541 55.987 1.00 44.88 ? 81 TYR A CE2 1 ATOM 102 C CZ . TYR A 1 15 ? 40.942 56.944 57.139 1.00 54.85 ? 81 TYR A CZ 1 ATOM 103 O OH . TYR A 1 15 ? 42.039 56.111 57.073 1.00 60.05 ? 81 TYR A OH 1 ATOM 104 N N . MET A 1 16 ? 40.027 61.981 58.080 1.00 36.78 ? 82 MET A N 1 ATOM 105 C CA . MET A 1 16 ? 41.302 62.546 57.614 1.00 38.34 ? 82 MET A CA 1 ATOM 106 C C . MET A 1 16 ? 41.223 63.696 56.591 1.00 38.86 ? 82 MET A C 1 ATOM 107 O O . MET A 1 16 ? 42.162 63.841 55.815 1.00 36.92 ? 82 MET A O 1 ATOM 108 C CB . MET A 1 16 ? 42.139 61.406 57.006 1.00 42.51 ? 82 MET A CB 1 ATOM 109 C CG . MET A 1 16 ? 43.008 60.666 57.981 1.00 50.23 ? 82 MET A CG 1 ATOM 110 S SD . MET A 1 16 ? 43.701 59.163 57.203 1.00 59.34 ? 82 MET A SD 1 ATOM 111 C CE . MET A 1 16 ? 44.252 59.783 55.433 1.00 56.23 ? 82 MET A CE 1 ATOM 112 N N . ASP A 1 17 ? 40.128 64.501 56.578 1.00 35.12 ? 83 ASP A N 1 ATOM 113 C CA . ASP A 1 17 ? 39.891 65.580 55.608 1.00 34.68 ? 83 ASP A CA 1 ATOM 114 C C . ASP A 1 17 ? 39.719 65.085 54.169 1.00 37.40 ? 83 ASP A C 1 ATOM 115 O O . ASP A 1 17 ? 39.681 65.899 53.255 1.00 37.35 ? 83 ASP A O 1 ATOM 116 C CB . ASP A 1 17 ? 40.974 66.691 55.684 1.00 36.43 ? 83 ASP A CB 1 ATOM 117 C CG . ASP A 1 17 ? 40.712 67.752 56.741 1.00 42.70 ? 83 ASP A CG 1 ATOM 118 O OD1 . ASP A 1 17 ? 39.697 67.627 57.476 1.00 40.57 ? 83 ASP A OD1 1 ATOM 119 O OD2 . ASP A 1 17 ? 41.466 68.742 56.780 1.00 49.50 ? 83 ASP A OD2 1 ATOM 120 N N . THR A 1 18 ? 39.601 63.769 53.962 1.00 32.58 ? 84 THR A N 1 ATOM 121 C CA . THR A 1 18 ? 39.470 63.225 52.614 1.00 32.20 ? 84 THR A CA 1 ATOM 122 C C . THR A 1 18 ? 38.164 62.483 52.384 1.00 35.68 ? 84 THR A C 1 ATOM 123 O O . THR A 1 18 ? 37.817 62.259 51.230 1.00 35.85 ? 84 THR A O 1 ATOM 124 C CB . THR A 1 18 ? 40.689 62.328 52.237 1.00 39.98 ? 84 THR A CB 1 ATOM 125 O OG1 . THR A 1 18 ? 40.836 61.276 53.192 1.00 43.23 ? 84 THR A OG1 1 ATOM 126 C CG2 . THR A 1 18 ? 41.982 63.088 52.127 1.00 30.28 ? 84 THR A CG2 1 ATOM 127 N N . GLN A 1 19 ? 37.479 62.018 53.453 1.00 29.94 ? 85 GLN A N 1 ATOM 128 C CA . GLN A 1 19 ? 36.213 61.287 53.287 1.00 28.89 ? 85 GLN A CA 1 ATOM 129 C C . GLN A 1 19 ? 35.231 61.793 54.300 1.00 33.05 ? 85 GLN A C 1 ATOM 130 O O . GLN A 1 19 ? 35.569 61.892 55.479 1.00 33.63 ? 85 GLN A O 1 ATOM 131 C CB . GLN A 1 19 ? 36.392 59.759 53.430 1.00 30.50 ? 85 GLN A CB 1 ATOM 132 C CG . GLN A 1 19 ? 37.359 59.125 52.413 1.00 27.29 ? 85 GLN A CG 1 ATOM 133 C CD . GLN A 1 19 ? 37.646 57.678 52.685 1.00 37.31 ? 85 GLN A CD 1 ATOM 134 O OE1 . GLN A 1 19 ? 36.744 56.881 52.923 1.00 31.96 ? 85 GLN A OE1 1 ATOM 135 N NE2 . GLN A 1 19 ? 38.903 57.290 52.608 1.00 26.62 ? 85 GLN A NE2 1 ATOM 136 N N . TYR A 1 20 ? 34.042 62.196 53.832 1.00 28.63 ? 86 TYR A N 1 ATOM 137 C CA . TYR A 1 20 ? 32.968 62.709 54.678 1.00 26.87 ? 86 TYR A CA 1 ATOM 138 C C . TYR A 1 20 ? 31.791 61.833 54.384 1.00 30.83 ? 86 TYR A C 1 ATOM 139 O O . TYR A 1 20 ? 31.438 61.659 53.225 1.00 30.24 ? 86 TYR A O 1 ATOM 140 C CB . TYR A 1 20 ? 32.646 64.185 54.376 1.00 25.15 ? 86 TYR A CB 1 ATOM 141 C CG . TYR A 1 20 ? 33.763 65.141 54.714 1.00 25.63 ? 86 TYR A CG 1 ATOM 142 C CD1 . TYR A 1 20 ? 34.831 65.328 53.845 1.00 26.51 ? 86 TYR A CD1 1 ATOM 143 C CD2 . TYR A 1 20 ? 33.729 65.904 55.880 1.00 26.42 ? 86 TYR A CD2 1 ATOM 144 C CE1 . TYR A 1 20 ? 35.869 66.197 54.154 1.00 25.67 ? 86 TYR A CE1 1 ATOM 145 C CE2 . TYR A 1 20 ? 34.750 66.809 56.180 1.00 26.46 ? 86 TYR A CE2 1 ATOM 146 C CZ . TYR A 1 20 ? 35.820 66.943 55.315 1.00 28.96 ? 86 TYR A CZ 1 ATOM 147 O OH . TYR A 1 20 ? 36.834 67.820 55.585 1.00 28.94 ? 86 TYR A OH 1 ATOM 148 N N . TYR A 1 21 ? 31.242 61.200 55.416 1.00 28.04 ? 87 TYR A N 1 ATOM 149 C CA . TYR A 1 21 ? 30.140 60.256 55.232 1.00 27.54 ? 87 TYR A CA 1 ATOM 150 C C . TYR A 1 21 ? 29.173 60.331 56.379 1.00 29.21 ? 87 TYR A C 1 ATOM 151 O O . TYR A 1 21 ? 29.541 60.724 57.465 1.00 29.04 ? 87 TYR A O 1 ATOM 152 C CB . TYR A 1 21 ? 30.679 58.801 55.037 1.00 28.91 ? 87 TYR A CB 1 ATOM 153 C CG . TYR A 1 21 ? 31.706 58.385 56.062 1.00 30.12 ? 87 TYR A CG 1 ATOM 154 C CD1 . TYR A 1 21 ? 31.321 57.805 57.277 1.00 30.86 ? 87 TYR A CD1 1 ATOM 155 C CD2 . TYR A 1 21 ? 33.059 58.585 55.833 1.00 31.28 ? 87 TYR A CD2 1 ATOM 156 C CE1 . TYR A 1 21 ? 32.266 57.450 58.240 1.00 29.27 ? 87 TYR A CE1 1 ATOM 157 C CE2 . TYR A 1 21 ? 34.008 58.261 56.797 1.00 32.66 ? 87 TYR A CE2 1 ATOM 158 C CZ . TYR A 1 21 ? 33.610 57.679 57.996 1.00 43.01 ? 87 TYR A CZ 1 ATOM 159 O OH . TYR A 1 21 ? 34.562 57.321 58.931 1.00 53.46 ? 87 TYR A OH 1 ATOM 160 N N . GLY A 1 22 ? 27.947 59.956 56.118 1.00 28.27 ? 88 GLY A N 1 ATOM 161 C CA . GLY A 1 22 ? 26.876 59.926 57.105 1.00 28.55 ? 88 GLY A CA 1 ATOM 162 C C . GLY A 1 22 ? 26.179 58.588 57.014 1.00 32.66 ? 88 GLY A C 1 ATOM 163 O O . GLY A 1 22 ? 26.528 57.753 56.173 1.00 34.32 ? 88 GLY A O 1 ATOM 164 N N . GLU A 1 23 ? 25.217 58.372 57.868 1.00 29.50 ? 89 GLU A N 1 ATOM 165 C CA . GLU A 1 23 ? 24.485 57.113 57.954 1.00 29.90 ? 89 GLU A CA 1 ATOM 166 C C . GLU A 1 23 ? 23.122 57.202 57.298 1.00 33.63 ? 89 GLU A C 1 ATOM 167 O O . GLU A 1 23 ? 22.467 58.238 57.355 1.00 33.65 ? 89 GLU A O 1 ATOM 168 C CB . GLU A 1 23 ? 24.332 56.708 59.437 1.00 31.36 ? 89 GLU A CB 1 ATOM 169 C CG . GLU A 1 23 ? 23.660 55.355 59.668 1.00 46.19 ? 89 GLU A CG 1 ATOM 170 C CD . GLU A 1 23 ? 23.486 54.942 61.117 1.00 62.27 ? 89 GLU A CD 1 ATOM 171 O OE1 . GLU A 1 23 ? 24.470 54.460 61.725 1.00 58.54 ? 89 GLU A OE1 1 ATOM 172 O OE2 . GLU A 1 23 ? 22.366 55.111 61.650 1.00 54.54 ? 89 GLU A OE2 1 ATOM 173 N N . ILE A 1 24 ? 22.725 56.112 56.657 1.00 30.21 ? 90 ILE A N 1 ATOM 174 C CA . ILE A 1 24 ? 21.392 55.824 56.084 1.00 29.40 ? 90 ILE A CA 1 ATOM 175 C C . ILE A 1 24 ? 21.013 54.389 56.579 1.00 32.51 ? 90 ILE A C 1 ATOM 176 O O . ILE A 1 24 ? 21.905 53.603 56.921 1.00 30.80 ? 90 ILE A O 1 ATOM 177 C CB . ILE A 1 24 ? 21.319 55.915 54.532 1.00 31.62 ? 90 ILE A CB 1 ATOM 178 C CG1 . ILE A 1 24 ? 22.230 54.828 53.855 1.00 30.94 ? 90 ILE A CG1 1 ATOM 179 C CG2 . ILE A 1 24 ? 21.592 57.351 54.028 1.00 30.56 ? 90 ILE A CG2 1 ATOM 180 C CD1 . ILE A 1 24 ? 21.857 54.435 52.462 1.00 28.49 ? 90 ILE A CD1 1 ATOM 181 N N . GLY A 1 25 ? 19.712 54.092 56.617 1.00 28.68 ? 91 GLY A N 1 ATOM 182 C CA . GLY A 1 25 ? 19.170 52.792 56.985 1.00 27.26 ? 91 GLY A CA 1 ATOM 183 C C . GLY A 1 25 ? 18.415 52.218 55.814 1.00 32.59 ? 91 GLY A C 1 ATOM 184 O O . GLY A 1 25 ? 17.579 52.906 55.234 1.00 34.33 ? 91 GLY A O 1 ATOM 185 N N . ILE A 1 26 ? 18.729 50.980 55.410 1.00 28.70 ? 92 ILE A N 1 ATOM 186 C CA . ILE A 1 26 ? 18.025 50.334 54.286 1.00 27.75 ? 92 ILE A CA 1 ATOM 187 C C . ILE A 1 26 ? 17.284 49.063 54.752 1.00 33.36 ? 92 ILE A C 1 ATOM 188 O O . ILE A 1 26 ? 17.888 48.185 55.387 1.00 31.79 ? 92 ILE A O 1 ATOM 189 C CB . ILE A 1 26 ? 18.922 50.035 53.038 1.00 28.56 ? 92 ILE A CB 1 ATOM 190 C CG1 . ILE A 1 26 ? 19.804 51.232 52.645 1.00 26.88 ? 92 ILE A CG1 1 ATOM 191 C CG2 . ILE A 1 26 ? 18.080 49.534 51.850 1.00 27.72 ? 92 ILE A CG2 1 ATOM 192 C CD1 . ILE A 1 26 ? 20.830 50.865 51.637 1.00 27.17 ? 92 ILE A CD1 1 ATOM 193 N N . GLY A 1 27 ? 15.994 48.993 54.408 1.00 30.18 ? 93 GLY A N 1 ATOM 194 C CA . GLY A 1 27 ? 15.155 47.842 54.710 1.00 30.82 ? 93 GLY A CA 1 ATOM 195 C C . GLY A 1 27 ? 14.401 47.846 56.022 1.00 34.85 ? 93 GLY A C 1 ATOM 196 O O . GLY A 1 27 ? 14.454 48.821 56.786 1.00 33.86 ? 93 GLY A O 1 ATOM 197 N N . THR A 1 28 ? 13.670 46.736 56.259 1.00 31.80 ? 94 THR A N 1 ATOM 198 C CA . THR A 1 28 ? 12.867 46.486 57.460 1.00 31.60 ? 94 THR A CA 1 ATOM 199 C C . THR A 1 28 ? 13.258 45.121 58.028 1.00 33.26 ? 94 THR A C 1 ATOM 200 O O . THR A 1 28 ? 12.980 44.113 57.375 1.00 33.76 ? 94 THR A O 1 ATOM 201 C CB . THR A 1 28 ? 11.350 46.599 57.182 1.00 42.43 ? 94 THR A CB 1 ATOM 202 O OG1 . THR A 1 28 ? 11.063 47.843 56.508 1.00 43.06 ? 94 THR A OG1 1 ATOM 203 C CG2 . THR A 1 28 ? 10.520 46.488 58.474 1.00 35.60 ? 94 THR A CG2 1 ATOM 204 N N . PRO A 1 29 ? 13.930 45.043 59.210 1.00 27.59 ? 95 PRO A N 1 ATOM 205 C CA . PRO A 1 29 ? 14.424 46.168 60.040 1.00 27.69 ? 95 PRO A CA 1 ATOM 206 C C . PRO A 1 29 ? 15.596 46.881 59.321 1.00 31.30 ? 95 PRO A C 1 ATOM 207 O O . PRO A 1 29 ? 16.197 46.295 58.412 1.00 26.71 ? 95 PRO A O 1 ATOM 208 C CB . PRO A 1 29 ? 14.869 45.467 61.338 1.00 28.52 ? 95 PRO A CB 1 ATOM 209 C CG . PRO A 1 29 ? 15.257 44.082 60.908 1.00 31.07 ? 95 PRO A CG 1 ATOM 210 C CD . PRO A 1 29 ? 14.357 43.733 59.756 1.00 26.74 ? 95 PRO A CD 1 ATOM 211 N N . PRO A 1 30 ? 15.945 48.128 59.676 1.00 30.10 ? 96 PRO A N 1 ATOM 212 C CA . PRO A 1 30 ? 17.041 48.795 58.948 1.00 29.30 ? 96 PRO A CA 1 ATOM 213 C C . PRO A 1 30 ? 18.421 48.165 59.137 1.00 32.30 ? 96 PRO A C 1 ATOM 214 O O . PRO A 1 30 ? 18.782 47.682 60.219 1.00 31.33 ? 96 PRO A O 1 ATOM 215 C CB . PRO A 1 30 ? 16.998 50.255 59.444 1.00 30.51 ? 96 PRO A CB 1 ATOM 216 C CG . PRO A 1 30 ? 15.740 50.380 60.231 1.00 34.89 ? 96 PRO A CG 1 ATOM 217 C CD . PRO A 1 30 ? 15.353 49.016 60.699 1.00 31.18 ? 96 PRO A CD 1 ATOM 218 N N . GLN A 1 31 ? 19.161 48.126 58.021 1.00 27.95 ? 97 GLN A N 1 ATOM 219 C CA . GLN A 1 31 ? 20.545 47.731 57.904 1.00 26.47 ? 97 GLN A CA 1 ATOM 220 C C . GLN A 1 31 ? 21.239 49.076 57.620 1.00 29.81 ? 97 GLN A C 1 ATOM 221 O O . GLN A 1 31 ? 20.866 49.769 56.680 1.00 27.04 ? 97 GLN A O 1 ATOM 222 C CB . GLN A 1 31 ? 20.728 46.742 56.747 1.00 27.64 ? 97 GLN A CB 1 ATOM 223 C CG . GLN A 1 31 ? 19.887 45.489 56.888 1.00 23.57 ? 97 GLN A CG 1 ATOM 224 C CD . GLN A 1 31 ? 19.998 44.560 55.722 1.00 36.38 ? 97 GLN A CD 1 ATOM 225 O OE1 . GLN A 1 31 ? 21.094 44.337 55.181 1.00 23.12 ? 97 GLN A OE1 1 ATOM 226 N NE2 . GLN A 1 31 ? 18.865 43.964 55.343 1.00 24.97 ? 97 GLN A NE2 1 ATOM 227 N N . THR A 1 32 ? 22.168 49.488 58.500 1.00 28.16 ? 98 THR A N 1 ATOM 228 C CA . THR A 1 32 ? 22.812 50.791 58.399 1.00 28.22 ? 98 THR A CA 1 ATOM 229 C C . THR A 1 32 ? 24.083 50.762 57.600 1.00 31.81 ? 98 THR A C 1 ATOM 230 O O . THR A 1 32 ? 24.841 49.794 57.666 1.00 31.05 ? 98 THR A O 1 ATOM 231 C CB . THR A 1 32 ? 23.029 51.420 59.769 1.00 32.94 ? 98 THR A CB 1 ATOM 232 O OG1 . THR A 1 32 ? 23.975 50.628 60.470 1.00 34.69 ? 98 THR A OG1 1 ATOM 233 C CG2 . THR A 1 32 ? 21.712 51.583 60.569 1.00 25.10 ? 98 THR A CG2 1 ATOM 234 N N . PHE A 1 33 ? 24.337 51.859 56.862 1.00 26.32 ? 99 PHE A N 1 ATOM 235 C CA . PHE A 1 33 ? 25.511 51.978 56.015 1.00 24.19 ? 99 PHE A CA 1 ATOM 236 C C . PHE A 1 33 ? 26.046 53.356 56.123 1.00 28.74 ? 99 PHE A C 1 ATOM 237 O O . PHE A 1 33 ? 25.269 54.304 56.260 1.00 24.83 ? 99 PHE A O 1 ATOM 238 C CB . PHE A 1 33 ? 25.145 51.722 54.533 1.00 23.97 ? 99 PHE A CB 1 ATOM 239 C CG . PHE A 1 33 ? 24.644 50.335 54.280 1.00 23.73 ? 99 PHE A CG 1 ATOM 240 C CD1 . PHE A 1 33 ? 23.295 50.028 54.429 1.00 25.76 ? 99 PHE A CD1 1 ATOM 241 C CD2 . PHE A 1 33 ? 25.512 49.331 53.867 1.00 22.31 ? 99 PHE A CD2 1 ATOM 242 C CE1 . PHE A 1 33 ? 22.839 48.722 54.233 1.00 24.71 ? 99 PHE A CE1 1 ATOM 243 C CE2 . PHE A 1 33 ? 25.045 48.052 53.619 1.00 23.84 ? 99 PHE A CE2 1 ATOM 244 C CZ . PHE A 1 33 ? 23.721 47.751 53.833 1.00 22.15 ? 99 PHE A CZ 1 ATOM 245 N N . LYS A 1 34 ? 27.391 53.459 55.990 1.00 27.77 ? 100 LYS A N 1 ATOM 246 C CA . LYS A 1 34 ? 28.155 54.707 55.953 1.00 26.76 ? 100 LYS A CA 1 ATOM 247 C C . LYS A 1 34 ? 28.193 55.086 54.482 1.00 27.56 ? 100 LYS A C 1 ATOM 248 O O . LYS A 1 34 ? 28.603 54.292 53.658 1.00 24.45 ? 100 LYS A O 1 ATOM 249 C CB . LYS A 1 34 ? 29.572 54.478 56.502 1.00 28.20 ? 100 LYS A CB 1 ATOM 250 C CG . LYS A 1 34 ? 29.608 54.260 57.997 1.00 26.18 ? 100 LYS A CG 1 ATOM 251 C CD . LYS A 1 34 ? 30.934 53.678 58.446 1.00 29.59 ? 100 LYS A CD 1 ATOM 252 C CE . LYS A 1 34 ? 30.830 53.296 59.912 1.00 46.67 ? 100 LYS A CE 1 ATOM 253 N NZ . LYS A 1 34 ? 32.025 52.585 60.415 1.00 58.15 ? 100 LYS A NZ 1 ATOM 254 N N . VAL A 1 35 ? 27.649 56.251 54.137 1.00 27.35 ? 101 VAL A N 1 ATOM 255 C CA . VAL A 1 35 ? 27.564 56.681 52.734 1.00 25.98 ? 101 VAL A CA 1 ATOM 256 C C . VAL A 1 35 ? 28.112 58.088 52.504 1.00 31.33 ? 101 VAL A C 1 ATOM 257 O O . VAL A 1 35 ? 28.006 58.950 53.382 1.00 30.63 ? 101 VAL A O 1 ATOM 258 C CB . VAL A 1 35 ? 26.141 56.533 52.151 1.00 26.77 ? 101 VAL A CB 1 ATOM 259 C CG1 . VAL A 1 35 ? 25.740 55.065 52.047 1.00 26.07 ? 101 VAL A CG1 1 ATOM 260 C CG2 . VAL A 1 35 ? 25.115 57.323 52.961 1.00 26.32 ? 101 VAL A CG2 1 ATOM 261 N N . VAL A 1 36 ? 28.684 58.306 51.309 1.00 28.15 ? 102 VAL A N 1 ATOM 262 C CA . VAL A 1 36 ? 29.133 59.613 50.828 1.00 27.21 ? 102 VAL A CA 1 ATOM 263 C C . VAL A 1 36 ? 27.901 60.254 50.159 1.00 28.82 ? 102 VAL A C 1 ATOM 264 O O . VAL A 1 36 ? 27.276 59.617 49.294 1.00 27.36 ? 102 VAL A O 1 ATOM 265 C CB . VAL A 1 36 ? 30.279 59.473 49.787 1.00 31.80 ? 102 VAL A CB 1 ATOM 266 C CG1 . VAL A 1 36 ? 30.686 60.837 49.214 1.00 31.15 ? 102 VAL A CG1 1 ATOM 267 C CG2 . VAL A 1 36 ? 31.477 58.755 50.385 1.00 31.54 ? 102 VAL A CG2 1 ATOM 268 N N . PHE A 1 37 ? 27.566 61.504 50.531 1.00 23.69 ? 103 PHE A N 1 ATOM 269 C CA . PHE A 1 37 ? 26.488 62.236 49.869 1.00 23.33 ? 103 PHE A CA 1 ATOM 270 C C . PHE A 1 37 ? 27.227 63.003 48.777 1.00 28.11 ? 103 PHE A C 1 ATOM 271 O O . PHE A 1 37 ? 28.038 63.900 49.036 1.00 25.46 ? 103 PHE A O 1 ATOM 272 C CB . PHE A 1 37 ? 25.690 63.102 50.855 1.00 24.53 ? 103 PHE A CB 1 ATOM 273 C CG . PHE A 1 37 ? 24.982 62.271 51.895 1.00 25.15 ? 103 PHE A CG 1 ATOM 274 C CD1 . PHE A 1 37 ? 23.733 61.711 51.633 1.00 29.23 ? 103 PHE A CD1 1 ATOM 275 C CD2 . PHE A 1 37 ? 25.570 62.022 53.126 1.00 25.53 ? 103 PHE A CD2 1 ATOM 276 C CE1 . PHE A 1 37 ? 23.087 60.907 52.597 1.00 29.50 ? 103 PHE A CE1 1 ATOM 277 C CE2 . PHE A 1 37 ? 24.906 61.271 54.100 1.00 28.70 ? 103 PHE A CE2 1 ATOM 278 C CZ . PHE A 1 37 ? 23.669 60.717 53.830 1.00 26.93 ? 103 PHE A CZ 1 ATOM 279 N N . ASP A 1 38 ? 27.061 62.505 47.559 1.00 26.68 ? 104 ASP A N 1 ATOM 280 C CA . ASP A 1 38 ? 27.869 62.848 46.390 1.00 26.17 ? 104 ASP A CA 1 ATOM 281 C C . ASP A 1 38 ? 27.171 63.622 45.249 1.00 32.12 ? 104 ASP A C 1 ATOM 282 O O . ASP A 1 38 ? 26.386 63.036 44.505 1.00 33.00 ? 104 ASP A O 1 ATOM 283 C CB . ASP A 1 38 ? 28.453 61.517 45.867 1.00 25.90 ? 104 ASP A CB 1 ATOM 284 C CG . ASP A 1 38 ? 29.402 61.613 44.718 1.00 31.88 ? 104 ASP A CG 1 ATOM 285 O OD1 . ASP A 1 38 ? 30.122 62.623 44.630 1.00 32.33 ? 104 ASP A OD1 1 ATOM 286 O OD2 . ASP A 1 38 ? 29.470 60.657 43.937 1.00 30.92 ? 104 ASP A OD2 1 ATOM 287 N N . THR A 1 39 ? 27.549 64.904 45.052 1.00 28.59 ? 105 THR A N 1 ATOM 288 C CA . THR A 1 39 ? 26.983 65.739 43.976 1.00 28.61 ? 105 THR A CA 1 ATOM 289 C C . THR A 1 39 ? 27.591 65.407 42.609 1.00 33.55 ? 105 THR A C 1 ATOM 290 O O . THR A 1 39 ? 27.042 65.813 41.590 1.00 35.88 ? 105 THR A O 1 ATOM 291 C CB . THR A 1 39 ? 27.049 67.232 44.295 1.00 34.09 ? 105 THR A CB 1 ATOM 292 O OG1 . THR A 1 39 ? 28.414 67.593 44.515 1.00 33.93 ? 105 THR A OG1 1 ATOM 293 C CG2 . THR A 1 39 ? 26.176 67.622 45.486 1.00 30.09 ? 105 THR A CG2 1 ATOM 294 N N . GLY A 1 40 ? 28.678 64.649 42.596 1.00 27.15 ? 106 GLY A N 1 ATOM 295 C CA . GLY A 1 40 ? 29.322 64.194 41.368 1.00 25.83 ? 106 GLY A CA 1 ATOM 296 C C . GLY A 1 40 ? 28.833 62.868 40.810 1.00 29.71 ? 106 GLY A C 1 ATOM 297 O O . GLY A 1 40 ? 29.483 62.296 39.936 1.00 31.00 ? 106 GLY A O 1 ATOM 298 N N . SER A 1 41 ? 27.711 62.340 41.311 1.00 26.02 ? 107 SER A N 1 ATOM 299 C CA . SER A 1 41 ? 27.100 61.078 40.827 1.00 25.81 ? 107 SER A CA 1 ATOM 300 C C . SER A 1 41 ? 25.598 61.113 41.163 1.00 29.37 ? 107 SER A C 1 ATOM 301 O O . SER A 1 41 ? 25.189 61.949 41.981 1.00 26.01 ? 107 SER A O 1 ATOM 302 C CB . SER A 1 41 ? 27.794 59.839 41.407 1.00 27.52 ? 107 SER A CB 1 ATOM 303 O OG . SER A 1 41 ? 27.387 59.556 42.736 1.00 30.50 ? 107 SER A OG 1 ATOM 304 N N . SER A 1 42 ? 24.780 60.231 40.523 1.00 25.77 ? 108 SER A N 1 ATOM 305 C CA . SER A 1 42 ? 23.334 60.267 40.714 1.00 24.98 ? 108 SER A CA 1 ATOM 306 C C . SER A 1 42 ? 22.696 58.950 41.153 1.00 31.47 ? 108 SER A C 1 ATOM 307 O O . SER A 1 42 ? 21.469 58.852 41.204 1.00 32.94 ? 108 SER A O 1 ATOM 308 C CB . SER A 1 42 ? 22.663 60.792 39.443 1.00 29.12 ? 108 SER A CB 1 ATOM 309 O OG . SER A 1 42 ? 23.310 61.938 38.899 1.00 40.67 ? 108 SER A OG 1 ATOM 310 N N . ASN A 1 43 ? 23.502 57.948 41.500 1.00 28.36 ? 109 ASN A N 1 ATOM 311 C CA . ASN A 1 43 ? 22.981 56.651 41.905 1.00 26.69 ? 109 ASN A CA 1 ATOM 312 C C . ASN A 1 43 ? 23.251 56.350 43.363 1.00 29.76 ? 109 ASN A C 1 ATOM 313 O O . ASN A 1 43 ? 24.281 56.744 43.904 1.00 30.28 ? 109 ASN A O 1 ATOM 314 C CB . ASN A 1 43 ? 23.603 55.547 41.042 1.00 22.66 ? 109 ASN A CB 1 ATOM 315 C CG . ASN A 1 43 ? 23.145 55.569 39.621 1.00 37.81 ? 109 ASN A CG 1 ATOM 316 O OD1 . ASN A 1 43 ? 23.613 56.384 38.825 1.00 38.43 ? 109 ASN A OD1 1 ATOM 317 N ND2 . ASN A 1 43 ? 22.245 54.657 39.261 1.00 24.72 ? 109 ASN A ND2 1 ATOM 318 N N . VAL A 1 44 ? 22.343 55.596 43.983 1.00 25.31 ? 110 VAL A N 1 ATOM 319 C CA . VAL A 1 44 ? 22.509 55.124 45.343 1.00 23.76 ? 110 VAL A CA 1 ATOM 320 C C . VAL A 1 44 ? 23.020 53.711 45.176 1.00 30.42 ? 110 VAL A C 1 ATOM 321 O O . VAL A 1 44 ? 22.500 52.963 44.341 1.00 31.28 ? 110 VAL A O 1 ATOM 322 C CB . VAL A 1 44 ? 21.182 55.153 46.171 1.00 26.03 ? 110 VAL A CB 1 ATOM 323 C CG1 . VAL A 1 44 ? 21.386 54.538 47.564 1.00 24.75 ? 110 VAL A CG1 1 ATOM 324 C CG2 . VAL A 1 44 ? 20.616 56.569 46.285 1.00 24.98 ? 110 VAL A CG2 1 ATOM 325 N N . TRP A 1 45 ? 24.066 53.352 45.919 1.00 27.63 ? 111 TRP A N 1 ATOM 326 C CA . TRP A 1 45 ? 24.578 51.988 45.951 1.00 26.67 ? 111 TRP A CA 1 ATOM 327 C C . TRP A 1 45 ? 25.228 51.688 47.279 1.00 27.92 ? 111 TRP A C 1 ATOM 328 O O . TRP A 1 45 ? 25.797 52.587 47.906 1.00 26.43 ? 111 TRP A O 1 ATOM 329 C CB . TRP A 1 45 ? 25.523 51.664 44.772 1.00 25.32 ? 111 TRP A CB 1 ATOM 330 C CG . TRP A 1 45 ? 26.863 52.343 44.790 1.00 25.52 ? 111 TRP A CG 1 ATOM 331 C CD1 . TRP A 1 45 ? 27.222 53.450 44.083 1.00 28.18 ? 111 TRP A CD1 1 ATOM 332 C CD2 . TRP A 1 45 ? 28.056 51.888 45.460 1.00 24.97 ? 111 TRP A CD2 1 ATOM 333 N NE1 . TRP A 1 45 ? 28.555 53.737 44.297 1.00 28.05 ? 111 TRP A NE1 1 ATOM 334 C CE2 . TRP A 1 45 ? 29.092 52.793 45.132 1.00 28.47 ? 111 TRP A CE2 1 ATOM 335 C CE3 . TRP A 1 45 ? 28.345 50.814 46.331 1.00 25.56 ? 111 TRP A CE3 1 ATOM 336 C CZ2 . TRP A 1 45 ? 30.388 52.663 45.634 1.00 27.35 ? 111 TRP A CZ2 1 ATOM 337 C CZ3 . TRP A 1 45 ? 29.636 50.680 46.820 1.00 26.34 ? 111 TRP A CZ3 1 ATOM 338 C CH2 . TRP A 1 45 ? 30.638 51.604 46.483 1.00 27.13 ? 111 TRP A CH2 1 ATOM 339 N N . VAL A 1 46 ? 25.171 50.416 47.686 1.00 22.37 ? 112 VAL A N 1 ATOM 340 C CA . VAL A 1 46 ? 25.814 49.888 48.894 1.00 20.18 ? 112 VAL A CA 1 ATOM 341 C C . VAL A 1 46 ? 26.414 48.515 48.526 1.00 25.94 ? 112 VAL A C 1 ATOM 342 O O . VAL A 1 46 ? 25.926 47.894 47.566 1.00 25.75 ? 112 VAL A O 1 ATOM 343 C CB . VAL A 1 46 ? 24.833 49.794 50.109 1.00 21.89 ? 112 VAL A CB 1 ATOM 344 C CG1 . VAL A 1 46 ? 24.511 51.176 50.676 1.00 21.24 ? 112 VAL A CG1 1 ATOM 345 C CG2 . VAL A 1 46 ? 23.565 49.006 49.776 1.00 20.93 ? 112 VAL A CG2 1 ATOM 346 N N . PRO A 1 47 ? 27.422 47.975 49.256 1.00 23.58 ? 113 PRO A N 1 ATOM 347 C CA . PRO A 1 47 ? 27.903 46.617 48.922 1.00 23.90 ? 113 PRO A CA 1 ATOM 348 C C . PRO A 1 47 ? 26.804 45.585 49.215 1.00 27.16 ? 113 PRO A C 1 ATOM 349 O O . PRO A 1 47 ? 25.990 45.794 50.115 1.00 25.55 ? 113 PRO A O 1 ATOM 350 C CB . PRO A 1 47 ? 29.128 46.440 49.821 1.00 25.57 ? 113 PRO A CB 1 ATOM 351 C CG . PRO A 1 47 ? 29.468 47.826 50.324 1.00 28.80 ? 113 PRO A CG 1 ATOM 352 C CD . PRO A 1 47 ? 28.145 48.510 50.424 1.00 24.44 ? 113 PRO A CD 1 ATOM 353 N N . SER A 1 48 ? 26.760 44.498 48.436 1.00 23.65 ? 114 SER A N 1 ATOM 354 C CA . SER A 1 48 ? 25.731 43.474 48.552 1.00 23.67 ? 114 SER A CA 1 ATOM 355 C C . SER A 1 48 ? 26.223 42.233 49.322 1.00 29.56 ? 114 SER A C 1 ATOM 356 O O . SER A 1 48 ? 27.418 41.934 49.305 1.00 30.83 ? 114 SER A O 1 ATOM 357 C CB . SER A 1 48 ? 25.268 43.057 47.151 1.00 25.69 ? 114 SER A CB 1 ATOM 358 O OG . SER A 1 48 ? 24.306 42.020 47.172 1.00 29.43 ? 114 SER A OG 1 ATOM 359 N N . SER A 1 49 ? 25.279 41.466 49.910 1.00 24.49 ? 115 SER A N 1 ATOM 360 C CA . SER A 1 49 ? 25.587 40.190 50.581 1.00 24.15 ? 115 SER A CA 1 ATOM 361 C C . SER A 1 49 ? 25.992 39.169 49.519 1.00 32.37 ? 115 SER A C 1 ATOM 362 O O . SER A 1 49 ? 26.709 38.220 49.817 1.00 34.30 ? 115 SER A O 1 ATOM 363 C CB . SER A 1 49 ? 24.385 39.666 51.369 1.00 22.03 ? 115 SER A CB 1 ATOM 364 O OG . SER A 1 49 ? 23.233 39.546 50.547 1.00 26.54 ? 115 SER A OG 1 ATOM 365 N N . LYS A 1 50 ? 25.558 39.394 48.272 1.00 31.15 ? 116 LYS A N 1 ATOM 366 C CA . LYS A 1 50 ? 25.855 38.565 47.097 1.00 31.33 ? 116 LYS A CA 1 ATOM 367 C C . LYS A 1 50 ? 27.226 38.900 46.474 1.00 33.88 ? 116 LYS A C 1 ATOM 368 O O . LYS A 1 50 ? 27.571 38.317 45.462 1.00 34.32 ? 116 LYS A O 1 ATOM 369 C CB . LYS A 1 50 ? 24.702 38.681 46.073 1.00 33.94 ? 116 LYS A CB 1 ATOM 370 C CG . LYS A 1 50 ? 23.390 38.102 46.632 1.00 33.76 ? 116 LYS A CG 1 ATOM 371 C CD . LYS A 1 50 ? 22.161 38.521 45.881 1.00 40.95 ? 116 LYS A CD 1 ATOM 372 C CE . LYS A 1 50 ? 20.886 38.011 46.548 1.00 44.24 ? 116 LYS A CE 1 ATOM 373 N NZ . LYS A 1 50 ? 20.397 38.886 47.643 1.00 39.09 ? 116 LYS A NZ 1 ATOM 374 N N . CYS A 1 51 ? 28.015 39.808 47.091 1.00 30.34 ? 117 CYS A N 1 ATOM 375 C CA . CYS A 1 51 ? 29.359 40.152 46.610 1.00 30.89 ? 117 CYS A CA 1 ATOM 376 C C . CYS A 1 51 ? 30.305 39.016 46.950 1.00 36.94 ? 117 CYS A C 1 ATOM 377 O O . CYS A 1 51 ? 30.419 38.694 48.128 1.00 35.21 ? 117 CYS A O 1 ATOM 378 C CB . CYS A 1 51 ? 29.858 41.463 47.222 1.00 30.52 ? 117 CYS A CB 1 ATOM 379 S SG . CYS A 1 51 ? 31.560 41.916 46.729 1.00 33.34 ? 117 CYS A SG 1 ATOM 380 N N . SER A 1 52 ? 31.018 38.441 45.946 1.00 37.25 ? 118 SER A N 1 ATOM 381 C CA . SER A 1 52 ? 31.990 37.372 46.219 1.00 38.07 ? 118 SER A CA 1 ATOM 382 C C . SER A 1 52 ? 33.035 37.869 47.181 1.00 41.54 ? 118 SER A C 1 ATOM 383 O O . SER A 1 52 ? 33.619 38.936 46.955 1.00 38.18 ? 118 SER A O 1 ATOM 384 C CB . SER A 1 52 ? 32.680 36.894 44.950 1.00 44.29 ? 118 SER A CB 1 ATOM 385 O OG . SER A 1 52 ? 33.748 36.029 45.321 1.00 56.43 ? 118 SER A OG 1 ATOM 386 N N . ARG A 1 53 ? 33.273 37.081 48.258 1.00 40.74 ? 119 ARG A N 1 ATOM 387 C CA . ARG A 1 53 ? 34.230 37.388 49.330 1.00 40.18 ? 119 ARG A CA 1 ATOM 388 C C . ARG A 1 53 ? 35.688 37.343 48.855 1.00 41.92 ? 119 ARG A C 1 ATOM 389 O O . ARG A 1 53 ? 36.595 37.590 49.654 1.00 42.14 ? 119 ARG A O 1 ATOM 390 C CB . ARG A 1 53 ? 33.974 36.511 50.563 1.00 43.43 ? 119 ARG A CB 1 ATOM 391 C CG . ARG A 1 53 ? 32.519 36.545 51.114 1.00 61.08 ? 119 ARG A CG 1 ATOM 392 C CD . ARG A 1 53 ? 31.974 37.942 51.458 1.00 69.66 ? 119 ARG A CD 1 ATOM 393 N NE . ARG A 1 53 ? 30.724 37.887 52.230 1.00 79.23 ? 119 ARG A NE 1 ATOM 394 C CZ . ARG A 1 53 ? 29.509 37.711 51.705 1.00 81.69 ? 119 ARG A CZ 1 ATOM 395 N NH1 . ARG A 1 53 ? 29.360 37.536 50.395 1.00 58.45 ? 119 ARG A NH1 1 ATOM 396 N NH2 . ARG A 1 53 ? 28.436 37.686 52.491 1.00 51.64 ? 119 ARG A NH2 1 ATOM 397 N N . LEU A 1 54 ? 35.895 37.051 47.538 1.00 36.75 ? 120 LEU A N 1 ATOM 398 C CA . LEU A 1 54 ? 37.144 37.154 46.818 1.00 36.48 ? 120 LEU A CA 1 ATOM 399 C C . LEU A 1 54 ? 37.413 38.664 46.469 1.00 40.64 ? 120 LEU A C 1 ATOM 400 O O . LEU A 1 54 ? 38.554 39.034 46.148 1.00 40.60 ? 120 LEU A O 1 ATOM 401 C CB . LEU A 1 54 ? 37.103 36.300 45.560 1.00 36.71 ? 120 LEU A CB 1 ATOM 402 C CG . LEU A 1 54 ? 37.316 34.791 45.751 1.00 40.59 ? 120 LEU A CG 1 ATOM 403 C CD1 . LEU A 1 54 ? 37.021 34.067 44.469 1.00 40.70 ? 120 LEU A CD1 1 ATOM 404 C CD2 . LEU A 1 54 ? 38.716 34.467 46.243 1.00 39.54 ? 120 LEU A CD2 1 ATOM 405 N N . TYR A 1 55 ? 36.355 39.533 46.554 1.00 34.24 ? 121 TYR A N 1 ATOM 406 C CA . TYR A 1 55 ? 36.498 40.985 46.500 1.00 32.49 ? 121 TYR A CA 1 ATOM 407 C C . TYR A 1 55 ? 36.651 41.316 47.985 1.00 35.80 ? 121 TYR A C 1 ATOM 408 O O . TYR A 1 55 ? 35.650 41.349 48.722 1.00 35.48 ? 121 TYR A O 1 ATOM 409 C CB . TYR A 1 55 ? 35.271 41.707 45.944 1.00 32.02 ? 121 TYR A CB 1 ATOM 410 C CG . TYR A 1 55 ? 35.118 41.572 44.458 1.00 32.35 ? 121 TYR A CG 1 ATOM 411 C CD1 . TYR A 1 55 ? 35.940 42.280 43.586 1.00 34.39 ? 121 TYR A CD1 1 ATOM 412 C CD2 . TYR A 1 55 ? 34.135 40.754 43.912 1.00 33.51 ? 121 TYR A CD2 1 ATOM 413 C CE1 . TYR A 1 55 ? 35.819 42.143 42.202 1.00 35.00 ? 121 TYR A CE1 1 ATOM 414 C CE2 . TYR A 1 55 ? 34.003 40.605 42.530 1.00 35.35 ? 121 TYR A CE2 1 ATOM 415 C CZ . TYR A 1 55 ? 34.840 41.314 41.677 1.00 46.21 ? 121 TYR A CZ 1 ATOM 416 O OH . TYR A 1 55 ? 34.711 41.194 40.311 1.00 55.16 ? 121 TYR A OH 1 ATOM 417 N N . THR A 1 56 ? 37.920 41.492 48.432 1.00 30.63 ? 122 THR A N 1 ATOM 418 C CA . THR A 1 56 ? 38.288 41.765 49.830 1.00 29.57 ? 122 THR A CA 1 ATOM 419 C C . THR A 1 56 ? 37.639 43.039 50.371 1.00 32.59 ? 122 THR A C 1 ATOM 420 O O . THR A 1 56 ? 37.342 43.075 51.558 1.00 32.67 ? 122 THR A O 1 ATOM 421 C CB . THR A 1 56 ? 39.820 41.737 50.007 1.00 31.05 ? 122 THR A CB 1 ATOM 422 O OG1 . THR A 1 56 ? 40.283 40.544 49.374 1.00 32.77 ? 122 THR A OG1 1 ATOM 423 C CG2 . THR A 1 56 ? 40.252 41.723 51.490 1.00 24.46 ? 122 THR A CG2 1 ATOM 424 N N . ALA A 1 57 ? 37.360 44.048 49.520 1.00 29.34 ? 123 ALA A N 1 ATOM 425 C CA . ALA A 1 57 ? 36.640 45.255 49.955 1.00 28.97 ? 123 ALA A CA 1 ATOM 426 C C . ALA A 1 57 ? 35.264 44.865 50.482 1.00 33.03 ? 123 ALA A C 1 ATOM 427 O O . ALA A 1 57 ? 34.786 45.516 51.386 1.00 33.80 ? 123 ALA A O 1 ATOM 428 C CB . ALA A 1 57 ? 36.500 46.255 48.813 1.00 29.57 ? 123 ALA A CB 1 ATOM 429 N N . CYS A 1 58 ? 34.651 43.784 49.976 1.00 29.04 ? 124 CYS A N 1 ATOM 430 C CA . CYS A 1 58 ? 33.375 43.320 50.502 1.00 29.39 ? 124 CYS A CA 1 ATOM 431 C C . CYS A 1 58 ? 33.478 42.662 51.898 1.00 37.26 ? 124 CYS A C 1 ATOM 432 O O . CYS A 1 58 ? 32.545 42.777 52.679 1.00 39.94 ? 124 CYS A O 1 ATOM 433 C CB . CYS A 1 58 ? 32.673 42.422 49.496 1.00 29.50 ? 124 CYS A CB 1 ATOM 434 S SG . CYS A 1 58 ? 32.045 43.328 48.072 1.00 33.14 ? 124 CYS A SG 1 ATOM 435 N N . VAL A 1 59 ? 34.617 42.037 52.236 1.00 32.31 ? 125 VAL A N 1 ATOM 436 C CA . VAL A 1 59 ? 34.880 41.442 53.550 1.00 30.22 ? 125 VAL A CA 1 ATOM 437 C C . VAL A 1 59 ? 34.989 42.580 54.604 1.00 34.75 ? 125 VAL A C 1 ATOM 438 O O . VAL A 1 59 ? 34.529 42.409 55.736 1.00 35.78 ? 125 VAL A O 1 ATOM 439 C CB . VAL A 1 59 ? 36.199 40.594 53.497 1.00 32.71 ? 125 VAL A CB 1 ATOM 440 C CG1 . VAL A 1 59 ? 36.557 40.014 54.865 1.00 31.50 ? 125 VAL A CG1 1 ATOM 441 C CG2 . VAL A 1 59 ? 36.116 39.485 52.450 1.00 32.04 ? 125 VAL A CG2 1 ATOM 442 N N . TYR A 1 60 ? 35.555 43.750 54.207 1.00 31.50 ? 126 TYR A N 1 ATOM 443 C CA . TYR A 1 60 ? 35.823 44.916 55.079 1.00 32.21 ? 126 TYR A CA 1 ATOM 444 C C . TYR A 1 60 ? 34.738 45.998 55.098 1.00 34.12 ? 126 TYR A C 1 ATOM 445 O O . TYR A 1 60 ? 34.929 47.064 55.704 1.00 34.90 ? 126 TYR A O 1 ATOM 446 C CB . TYR A 1 60 ? 37.195 45.515 54.738 1.00 35.89 ? 126 TYR A CB 1 ATOM 447 C CG . TYR A 1 60 ? 38.281 44.605 55.272 1.00 40.26 ? 126 TYR A CG 1 ATOM 448 C CD1 . TYR A 1 60 ? 38.669 44.670 56.607 1.00 43.96 ? 126 TYR A CD1 1 ATOM 449 C CD2 . TYR A 1 60 ? 38.790 43.560 54.495 1.00 40.14 ? 126 TYR A CD2 1 ATOM 450 C CE1 . TYR A 1 60 ? 39.586 43.772 57.137 1.00 47.70 ? 126 TYR A CE1 1 ATOM 451 C CE2 . TYR A 1 60 ? 39.717 42.659 55.016 1.00 40.94 ? 126 TYR A CE2 1 ATOM 452 C CZ . TYR A 1 60 ? 40.125 42.785 56.335 1.00 54.07 ? 126 TYR A CZ 1 ATOM 453 O OH . TYR A 1 60 ? 41.036 41.940 56.908 1.00 61.83 ? 126 TYR A OH 1 ATOM 454 N N . HIS A 1 61 ? 33.574 45.688 54.520 1.00 27.39 ? 127 HIS A N 1 ATOM 455 C CA . HIS A 1 61 ? 32.452 46.607 54.505 1.00 25.93 ? 127 HIS A CA 1 ATOM 456 C C . HIS A 1 61 ? 31.148 45.940 54.913 1.00 29.09 ? 127 HIS A C 1 ATOM 457 O O . HIS A 1 61 ? 31.046 44.716 54.917 1.00 29.32 ? 127 HIS A O 1 ATOM 458 C CB . HIS A 1 61 ? 32.316 47.317 53.142 1.00 25.52 ? 127 HIS A CB 1 ATOM 459 C CG . HIS A 1 61 ? 33.392 48.323 52.919 1.00 28.08 ? 127 HIS A CG 1 ATOM 460 N ND1 . HIS A 1 61 ? 34.498 48.024 52.169 1.00 29.33 ? 127 HIS A ND1 1 ATOM 461 C CD2 . HIS A 1 61 ? 33.536 49.564 53.433 1.00 29.84 ? 127 HIS A CD2 1 ATOM 462 C CE1 . HIS A 1 61 ? 35.263 49.093 52.207 1.00 28.56 ? 127 HIS A CE1 1 ATOM 463 N NE2 . HIS A 1 61 ? 34.725 50.049 52.957 1.00 29.59 ? 127 HIS A NE2 1 ATOM 464 N N . LYS A 1 62 ? 30.171 46.761 55.292 1.00 24.57 ? 128 LYS A N 1 ATOM 465 C CA . LYS A 1 62 ? 28.825 46.340 55.635 1.00 23.95 ? 128 LYS A CA 1 ATOM 466 C C . LYS A 1 62 ? 28.133 45.969 54.312 1.00 27.74 ? 128 LYS A C 1 ATOM 467 O O . LYS A 1 62 ? 28.289 46.674 53.308 1.00 24.74 ? 128 LYS A O 1 ATOM 468 C CB . LYS A 1 62 ? 28.091 47.490 56.351 1.00 25.93 ? 128 LYS A CB 1 ATOM 469 C CG . LYS A 1 62 ? 26.659 47.157 56.780 1.00 37.27 ? 128 LYS A CG 1 ATOM 470 C CD . LYS A 1 62 ? 26.572 46.293 58.045 1.00 34.27 ? 128 LYS A CD 1 ATOM 471 C CE . LYS A 1 62 ? 25.367 46.685 58.858 1.00 42.54 ? 128 LYS A CE 1 ATOM 472 N NZ . LYS A 1 62 ? 25.594 47.933 59.665 1.00 40.93 ? 128 LYS A NZ 1 ATOM 473 N N . LEU A 1 63 ? 27.418 44.831 54.296 1.00 26.65 ? 129 LEU A N 1 ATOM 474 C CA . LEU A 1 63 ? 26.764 44.339 53.078 1.00 25.83 ? 129 LEU A CA 1 ATOM 475 C C . LEU A 1 63 ? 25.280 44.277 53.258 1.00 30.46 ? 129 LEU A C 1 ATOM 476 O O . LEU A 1 63 ? 24.815 43.838 54.304 1.00 30.83 ? 129 LEU A O 1 ATOM 477 C CB . LEU A 1 63 ? 27.295 42.947 52.701 1.00 25.54 ? 129 LEU A CB 1 ATOM 478 C CG . LEU A 1 63 ? 28.806 42.740 52.731 1.00 28.92 ? 129 LEU A CG 1 ATOM 479 C CD1 . LEU A 1 63 ? 29.142 41.233 52.766 1.00 29.18 ? 129 LEU A CD1 1 ATOM 480 C CD2 . LEU A 1 63 ? 29.484 43.376 51.515 1.00 25.09 ? 129 LEU A CD2 1 ATOM 481 N N . PHE A 1 64 ? 24.525 44.672 52.229 1.00 27.51 ? 130 PHE A N 1 ATOM 482 C CA . PHE A 1 64 ? 23.076 44.609 52.255 1.00 25.75 ? 130 PHE A CA 1 ATOM 483 C C . PHE A 1 64 ? 22.595 43.196 51.992 1.00 31.72 ? 130 PHE A C 1 ATOM 484 O O . PHE A 1 64 ? 22.932 42.614 50.953 1.00 32.45 ? 130 PHE A O 1 ATOM 485 C CB . PHE A 1 64 ? 22.430 45.590 51.246 1.00 26.15 ? 130 PHE A CB 1 ATOM 486 C CG . PHE A 1 64 ? 20.908 45.512 51.220 1.00 25.55 ? 130 PHE A CG 1 ATOM 487 C CD1 . PHE A 1 64 ? 20.150 46.014 52.273 1.00 26.83 ? 130 PHE A CD1 1 ATOM 488 C CD2 . PHE A 1 64 ? 20.244 44.933 50.148 1.00 25.36 ? 130 PHE A CD2 1 ATOM 489 C CE1 . PHE A 1 64 ? 18.755 45.939 52.244 1.00 27.34 ? 130 PHE A CE1 1 ATOM 490 C CE2 . PHE A 1 64 ? 18.843 44.852 50.125 1.00 27.45 ? 130 PHE A CE2 1 ATOM 491 C CZ . PHE A 1 64 ? 18.110 45.358 51.172 1.00 25.26 ? 130 PHE A CZ 1 ATOM 492 N N . ASP A 1 65 ? 21.744 42.681 52.897 1.00 29.02 ? 131 ASP A N 1 ATOM 493 C CA . ASP A 1 65 ? 21.141 41.357 52.763 1.00 28.76 ? 131 ASP A CA 1 ATOM 494 C C . ASP A 1 65 ? 19.642 41.524 52.584 1.00 32.60 ? 131 ASP A C 1 ATOM 495 O O . ASP A 1 65 ? 18.929 41.855 53.538 1.00 31.73 ? 131 ASP A O 1 ATOM 496 C CB . ASP A 1 65 ? 21.489 40.444 53.968 1.00 29.73 ? 131 ASP A CB 1 ATOM 497 C CG . ASP A 1 65 ? 21.406 38.945 53.670 1.00 38.02 ? 131 ASP A CG 1 ATOM 498 O OD1 . ASP A 1 65 ? 20.660 38.554 52.718 1.00 35.52 ? 131 ASP A OD1 1 ATOM 499 O OD2 . ASP A 1 65 ? 22.086 38.160 54.375 1.00 41.85 ? 131 ASP A OD2 1 ATOM 500 N N . ALA A 1 66 ? 19.174 41.354 51.335 1.00 29.28 ? 132 ALA A N 1 ATOM 501 C CA . ALA A 1 66 ? 17.764 41.486 50.956 1.00 28.34 ? 132 ALA A CA 1 ATOM 502 C C . ALA A 1 66 ? 16.887 40.432 51.690 1.00 31.57 ? 132 ALA A C 1 ATOM 503 O O . ALA A 1 66 ? 15.718 40.689 52.006 1.00 30.37 ? 132 ALA A O 1 ATOM 504 C CB . ALA A 1 66 ? 17.620 41.340 49.442 1.00 28.34 ? 132 ALA A CB 1 ATOM 505 N N . SER A 1 67 ? 17.483 39.264 51.979 1.00 27.78 ? 133 SER A N 1 ATOM 506 C CA . SER A 1 67 ? 16.871 38.112 52.673 1.00 27.40 ? 133 SER A CA 1 ATOM 507 C C . SER A 1 67 ? 16.483 38.421 54.109 1.00 31.86 ? 133 SER A C 1 ATOM 508 O O . SER A 1 67 ? 15.753 37.635 54.695 1.00 33.58 ? 133 SER A O 1 ATOM 509 C CB . SER A 1 67 ? 17.803 36.905 52.629 1.00 30.96 ? 133 SER A CB 1 ATOM 510 O OG . SER A 1 67 ? 17.828 36.341 51.328 1.00 45.55 ? 133 SER A OG 1 ATOM 511 N N . ASP A 1 68 ? 16.970 39.554 54.677 1.00 26.80 ? 134 ASP A N 1 ATOM 512 C CA . ASP A 1 68 ? 16.647 39.988 56.031 1.00 26.63 ? 134 ASP A CA 1 ATOM 513 C C . ASP A 1 68 ? 15.707 41.179 56.040 1.00 31.04 ? 134 ASP A C 1 ATOM 514 O O . ASP A 1 68 ? 15.409 41.718 57.098 1.00 31.69 ? 134 ASP A O 1 ATOM 515 C CB . ASP A 1 68 ? 17.936 40.305 56.802 1.00 28.71 ? 134 ASP A CB 1 ATOM 516 C CG . ASP A 1 68 ? 18.816 39.097 57.020 1.00 37.98 ? 134 ASP A CG 1 ATOM 517 O OD1 . ASP A 1 68 ? 18.281 37.973 57.054 1.00 38.44 ? 134 ASP A OD1 1 ATOM 518 O OD2 . ASP A 1 68 ? 20.043 39.278 57.166 1.00 44.52 ? 134 ASP A OD2 1 ATOM 519 N N . SER A 1 69 ? 15.234 41.604 54.864 1.00 28.91 ? 135 SER A N 1 ATOM 520 C CA . SER A 1 69 ? 14.348 42.759 54.739 1.00 28.19 ? 135 SER A CA 1 ATOM 521 C C . SER A 1 69 ? 12.974 42.377 54.190 1.00 33.21 ? 135 SER A C 1 ATOM 522 O O . SER A 1 69 ? 12.875 41.837 53.079 1.00 31.30 ? 135 SER A O 1 ATOM 523 C CB . SER A 1 69 ? 14.991 43.863 53.905 1.00 28.19 ? 135 SER A CB 1 ATOM 524 O OG . SER A 1 69 ? 14.069 44.924 53.701 1.00 35.25 ? 135 SER A OG 1 ATOM 525 N N . SER A 1 70 ? 11.913 42.678 54.987 1.00 31.74 ? 136 SER A N 1 ATOM 526 C CA . SER A 1 70 ? 10.520 42.394 54.629 1.00 31.65 ? 136 SER A CA 1 ATOM 527 C C . SER A 1 70 ? 9.951 43.404 53.614 1.00 36.32 ? 136 SER A C 1 ATOM 528 O O . SER A 1 70 ? 8.990 43.087 52.905 1.00 37.93 ? 136 SER A O 1 ATOM 529 C CB . SER A 1 70 ? 9.643 42.322 55.874 1.00 33.51 ? 136 SER A CB 1 ATOM 530 O OG . SER A 1 70 ? 9.534 43.563 56.543 1.00 40.71 ? 136 SER A OG 1 ATOM 531 N N . SER A 1 71 ? 10.565 44.596 53.522 1.00 31.00 ? 137 SER A N 1 ATOM 532 C CA . SER A 1 71 ? 10.129 45.678 52.621 1.00 28.99 ? 137 SER A CA 1 ATOM 533 C C . SER A 1 71 ? 10.838 45.673 51.256 1.00 32.65 ? 137 SER A C 1 ATOM 534 O O . SER A 1 71 ? 10.518 46.491 50.388 1.00 32.87 ? 137 SER A O 1 ATOM 535 C CB . SER A 1 71 ? 10.279 47.027 53.303 1.00 29.64 ? 137 SER A CB 1 ATOM 536 O OG . SER A 1 71 ? 11.529 47.126 53.962 1.00 41.07 ? 137 SER A OG 1 ATOM 537 N N . TYR A 1 72 ? 11.783 44.739 51.062 1.00 28.94 ? 138 TYR A N 1 ATOM 538 C CA . TYR A 1 72 ? 12.549 44.592 49.832 1.00 27.90 ? 138 TYR A CA 1 ATOM 539 C C . TYR A 1 72 ? 11.662 44.200 48.650 1.00 34.75 ? 138 TYR A C 1 ATOM 540 O O . TYR A 1 72 ? 10.755 43.349 48.790 1.00 35.76 ? 138 TYR A O 1 ATOM 541 C CB . TYR A 1 72 ? 13.677 43.577 50.049 1.00 27.96 ? 138 TYR A CB 1 ATOM 542 C CG . TYR A 1 72 ? 14.277 42.992 48.788 1.00 29.19 ? 138 TYR A CG 1 ATOM 543 C CD1 . TYR A 1 72 ? 15.170 43.731 48.004 1.00 29.38 ? 138 TYR A CD1 1 ATOM 544 C CD2 . TYR A 1 72 ? 13.963 41.698 48.380 1.00 28.84 ? 138 TYR A CD2 1 ATOM 545 C CE1 . TYR A 1 72 ? 15.731 43.191 46.849 1.00 26.18 ? 138 TYR A CE1 1 ATOM 546 C CE2 . TYR A 1 72 ? 14.519 41.149 47.231 1.00 29.69 ? 138 TYR A CE2 1 ATOM 547 C CZ . TYR A 1 72 ? 15.410 41.894 46.473 1.00 35.81 ? 138 TYR A CZ 1 ATOM 548 O OH . TYR A 1 72 ? 15.969 41.326 45.359 1.00 35.32 ? 138 TYR A OH 1 ATOM 549 N N . LYS A 1 73 ? 11.917 44.844 47.491 1.00 29.49 ? 139 LYS A N 1 ATOM 550 C CA . LYS A 1 73 ? 11.230 44.530 46.226 1.00 29.60 ? 139 LYS A CA 1 ATOM 551 C C . LYS A 1 73 ? 12.297 44.250 45.174 1.00 31.36 ? 139 LYS A C 1 ATOM 552 O O . LYS A 1 73 ? 13.135 45.115 44.885 1.00 30.44 ? 139 LYS A O 1 ATOM 553 C CB . LYS A 1 73 ? 10.276 45.660 45.755 1.00 31.46 ? 139 LYS A CB 1 ATOM 554 C CG . LYS A 1 73 ? 9.188 46.048 46.723 1.00 33.52 ? 139 LYS A CG 1 ATOM 555 C CD . LYS A 1 73 ? 8.036 45.065 46.755 1.00 41.36 ? 139 LYS A CD 1 ATOM 556 C CE . LYS A 1 73 ? 6.816 45.646 47.440 1.00 52.55 ? 139 LYS A CE 1 ATOM 557 N NZ . LYS A 1 73 ? 7.006 45.818 48.910 1.00 71.91 ? 139 LYS A NZ 1 ATOM 558 N N . HIS A 1 74 ? 12.279 43.046 44.627 1.00 28.06 ? 140 HIS A N 1 ATOM 559 C CA . HIS A 1 74 ? 13.250 42.588 43.639 1.00 29.44 ? 140 HIS A CA 1 ATOM 560 C C . HIS A 1 74 ? 13.201 43.370 42.317 1.00 36.53 ? 140 HIS A C 1 ATOM 561 O O . HIS A 1 74 ? 12.118 43.752 41.862 1.00 37.56 ? 140 HIS A O 1 ATOM 562 C CB . HIS A 1 74 ? 13.077 41.063 43.414 1.00 29.88 ? 140 HIS A CB 1 ATOM 563 C CG . HIS A 1 74 ? 13.653 40.534 42.129 1.00 33.82 ? 140 HIS A CG 1 ATOM 564 N ND1 . HIS A 1 74 ? 12.862 40.427 40.972 1.00 35.99 ? 140 HIS A ND1 1 ATOM 565 C CD2 . HIS A 1 74 ? 14.904 40.096 41.835 1.00 34.90 ? 140 HIS A CD2 1 ATOM 566 C CE1 . HIS A 1 74 ? 13.645 39.901 40.040 1.00 34.38 ? 140 HIS A CE1 1 ATOM 567 N NE2 . HIS A 1 74 ? 14.884 39.696 40.499 1.00 34.50 ? 140 HIS A NE2 1 ATOM 568 N N . ASN A 1 75 ? 14.373 43.574 41.694 1.00 32.03 ? 141 ASN A N 1 ATOM 569 C CA . ASN A 1 75 ? 14.468 44.142 40.362 1.00 30.78 ? 141 ASN A CA 1 ATOM 570 C C . ASN A 1 75 ? 15.434 43.291 39.552 1.00 34.65 ? 141 ASN A C 1 ATOM 571 O O . ASN A 1 75 ? 14.993 42.540 38.679 1.00 35.27 ? 141 ASN A O 1 ATOM 572 C CB . ASN A 1 75 ? 14.753 45.637 40.331 1.00 32.03 ? 141 ASN A CB 1 ATOM 573 C CG . ASN A 1 75 ? 14.640 46.162 38.927 1.00 47.69 ? 141 ASN A CG 1 ATOM 574 O OD1 . ASN A 1 75 ? 15.589 46.063 38.153 1.00 33.60 ? 141 ASN A OD1 1 ATOM 575 N ND2 . ASN A 1 75 ? 13.462 46.671 38.572 1.00 54.53 ? 141 ASN A ND2 1 ATOM 576 N N . GLY A 1 76 ? 16.709 43.324 39.896 1.00 29.84 ? 142 GLY A N 1 ATOM 577 C CA . GLY A 1 76 ? 17.693 42.454 39.260 1.00 29.82 ? 142 GLY A CA 1 ATOM 578 C C . GLY A 1 76 ? 18.431 42.974 38.045 1.00 33.09 ? 142 GLY A C 1 ATOM 579 O O . GLY A 1 76 ? 19.397 42.338 37.617 1.00 31.64 ? 142 GLY A O 1 ATOM 580 N N . THR A 1 77 ? 17.996 44.119 37.483 1.00 30.60 ? 143 THR A N 1 ATOM 581 C CA . THR A 1 77 ? 18.647 44.746 36.321 1.00 31.09 ? 143 THR A CA 1 ATOM 582 C C . THR A 1 77 ? 20.115 45.040 36.628 1.00 36.60 ? 143 THR A C 1 ATOM 583 O O . THR A 1 77 ? 20.421 45.633 37.664 1.00 34.37 ? 143 THR A O 1 ATOM 584 C CB . THR A 1 77 ? 17.912 46.041 35.907 1.00 38.75 ? 143 THR A CB 1 ATOM 585 O OG1 . THR A 1 77 ? 16.557 45.724 35.628 1.00 40.82 ? 143 THR A OG1 1 ATOM 586 C CG2 . THR A 1 77 ? 18.533 46.717 34.684 1.00 35.38 ? 143 THR A CG2 1 ATOM 587 N N . GLU A 1 78 ? 21.014 44.622 35.721 1.00 37.00 ? 144 GLU A N 1 ATOM 588 C CA . GLU A 1 78 ? 22.457 44.848 35.832 1.00 37.27 ? 144 GLU A CA 1 ATOM 589 C C . GLU A 1 78 ? 22.754 46.349 35.876 1.00 40.47 ? 144 GLU A C 1 ATOM 590 O O . GLU A 1 78 ? 22.038 47.147 35.280 1.00 40.59 ? 144 GLU A O 1 ATOM 591 C CB . GLU A 1 78 ? 23.182 44.204 34.662 1.00 39.25 ? 144 GLU A CB 1 ATOM 592 C CG . GLU A 1 78 ? 24.421 43.432 35.074 1.00 62.90 ? 144 GLU A CG 1 ATOM 593 C CD . GLU A 1 78 ? 25.687 43.848 34.341 1.00 98.91 ? 144 GLU A CD 1 ATOM 594 O OE1 . GLU A 1 78 ? 26.511 44.575 34.944 1.00 97.52 ? 144 GLU A OE1 1 ATOM 595 O OE2 . GLU A 1 78 ? 25.849 43.456 33.161 1.00 95.42 ? 144 GLU A OE2 1 ATOM 596 N N . LEU A 1 79 ? 23.799 46.726 36.607 1.00 35.87 ? 145 LEU A N 1 ATOM 597 C CA . LEU A 1 79 ? 24.195 48.104 36.770 1.00 34.60 ? 145 LEU A CA 1 ATOM 598 C C . LEU A 1 79 ? 25.710 48.193 36.863 1.00 36.89 ? 145 LEU A C 1 ATOM 599 O O . LEU A 1 79 ? 26.324 47.477 37.657 1.00 35.90 ? 145 LEU A O 1 ATOM 600 C CB . LEU A 1 79 ? 23.501 48.677 38.040 1.00 34.84 ? 145 LEU A CB 1 ATOM 601 C CG . LEU A 1 79 ? 23.910 50.072 38.531 1.00 39.74 ? 145 LEU A CG 1 ATOM 602 C CD1 . LEU A 1 79 ? 23.412 51.193 37.626 1.00 40.43 ? 145 LEU A CD1 1 ATOM 603 C CD2 . LEU A 1 79 ? 23.546 50.297 39.947 1.00 41.51 ? 145 LEU A CD2 1 ATOM 604 N N . THR A 1 80 ? 26.315 49.032 36.001 1.00 33.40 ? 146 THR A N 1 ATOM 605 C CA . THR A 1 80 ? 27.749 49.303 35.989 1.00 32.75 ? 146 THR A CA 1 ATOM 606 C C . THR A 1 80 ? 27.940 50.791 36.161 1.00 36.30 ? 146 THR A C 1 ATOM 607 O O . THR A 1 80 ? 27.361 51.583 35.411 1.00 35.82 ? 146 THR A O 1 ATOM 608 C CB . THR A 1 80 ? 28.479 48.715 34.762 1.00 37.23 ? 146 THR A CB 1 ATOM 609 O OG1 . THR A 1 80 ? 28.264 47.300 34.708 1.00 40.41 ? 146 THR A OG1 1 ATOM 610 C CG2 . THR A 1 80 ? 29.975 48.979 34.799 1.00 32.34 ? 146 THR A CG2 1 ATOM 611 N N . LEU A 1 81 ? 28.704 51.171 37.199 1.00 31.92 ? 147 LEU A N 1 ATOM 612 C CA . LEU A 1 81 ? 28.993 52.570 37.501 1.00 31.26 ? 147 LEU A CA 1 ATOM 613 C C . LEU A 1 81 ? 30.479 52.810 37.310 1.00 35.06 ? 147 LEU A C 1 ATOM 614 O O . LEU A 1 81 ? 31.306 52.379 38.121 1.00 33.43 ? 147 LEU A O 1 ATOM 615 C CB . LEU A 1 81 ? 28.547 52.933 38.929 1.00 31.20 ? 147 LEU A CB 1 ATOM 616 C CG . LEU A 1 81 ? 27.098 52.645 39.296 1.00 34.89 ? 147 LEU A CG 1 ATOM 617 C CD1 . LEU A 1 81 ? 26.917 52.702 40.772 1.00 34.38 ? 147 LEU A CD1 1 ATOM 618 C CD2 . LEU A 1 81 ? 26.165 53.638 38.641 1.00 35.78 ? 147 LEU A CD2 1 ATOM 619 N N . ARG A 1 82 ? 30.821 53.443 36.199 1.00 34.75 ? 148 ARG A N 1 ATOM 620 C CA . ARG A 1 82 ? 32.208 53.730 35.866 1.00 36.06 ? 148 ARG A CA 1 ATOM 621 C C . ARG A 1 82 ? 32.520 55.125 36.342 1.00 38.64 ? 148 ARG A C 1 ATOM 622 O O . ARG A 1 82 ? 32.021 56.092 35.782 1.00 39.77 ? 148 ARG A O 1 ATOM 623 C CB . ARG A 1 82 ? 32.487 53.559 34.354 1.00 38.75 ? 148 ARG A CB 1 ATOM 624 C CG . ARG A 1 82 ? 32.501 52.136 33.847 1.00 50.49 ? 148 ARG A CG 1 ATOM 625 C CD . ARG A 1 82 ? 32.436 52.122 32.327 1.00 55.96 ? 148 ARG A CD 1 ATOM 626 N NE . ARG A 1 82 ? 32.010 50.824 31.788 1.00 66.11 ? 148 ARG A NE 1 ATOM 627 C CZ . ARG A 1 82 ? 30.744 50.475 31.556 1.00 77.84 ? 148 ARG A CZ 1 ATOM 628 N NH1 . ARG A 1 82 ? 29.753 51.311 31.843 1.00 59.58 ? 148 ARG A NH1 1 ATOM 629 N NH2 . ARG A 1 82 ? 30.460 49.278 31.060 1.00 67.16 ? 148 ARG A NH2 1 ATOM 630 N N . TYR A 1 83 ? 33.319 55.226 37.391 1.00 33.78 ? 149 TYR A N 1 ATOM 631 C CA . TYR A 1 83 ? 33.735 56.492 37.972 1.00 33.75 ? 149 TYR A CA 1 ATOM 632 C C . TYR A 1 83 ? 35.184 56.776 37.580 1.00 40.97 ? 149 TYR A C 1 ATOM 633 O O . TYR A 1 83 ? 35.891 55.891 37.080 1.00 41.98 ? 149 TYR A O 1 ATOM 634 C CB . TYR A 1 83 ? 33.666 56.433 39.517 1.00 33.65 ? 149 TYR A CB 1 ATOM 635 C CG . TYR A 1 83 ? 32.312 56.099 40.113 1.00 34.20 ? 149 TYR A CG 1 ATOM 636 C CD1 . TYR A 1 83 ? 31.203 56.902 39.866 1.00 34.46 ? 149 TYR A CD1 1 ATOM 637 C CD2 . TYR A 1 83 ? 32.174 55.073 41.051 1.00 33.89 ? 149 TYR A CD2 1 ATOM 638 C CE1 . TYR A 1 83 ? 29.972 56.633 40.459 1.00 34.45 ? 149 TYR A CE1 1 ATOM 639 C CE2 . TYR A 1 83 ? 30.941 54.789 41.644 1.00 33.92 ? 149 TYR A CE2 1 ATOM 640 C CZ . TYR A 1 83 ? 29.846 55.581 41.355 1.00 40.91 ? 149 TYR A CZ 1 ATOM 641 O OH . TYR A 1 83 ? 28.633 55.341 41.961 1.00 41.02 ? 149 TYR A OH 1 ATOM 642 N N . SER A 1 84 ? 35.648 57.996 37.901 1.00 36.84 ? 150 SER A N 1 ATOM 643 C CA . SER A 1 84 ? 37.011 58.459 37.681 1.00 36.26 ? 150 SER A CA 1 ATOM 644 C C . SER A 1 84 ? 38.027 57.690 38.534 1.00 38.36 ? 150 SER A C 1 ATOM 645 O O . SER A 1 84 ? 39.198 57.595 38.174 1.00 38.15 ? 150 SER A O 1 ATOM 646 C CB . SER A 1 84 ? 37.094 59.947 38.003 1.00 41.08 ? 150 SER A CB 1 ATOM 647 O OG . SER A 1 84 ? 36.089 60.630 37.266 1.00 54.55 ? 150 SER A OG 1 ATOM 648 N N . THR A 1 85 ? 37.596 57.200 39.693 1.00 34.80 ? 151 THR A N 1 ATOM 649 C CA . THR A 1 85 ? 38.473 56.492 40.635 1.00 34.00 ? 151 THR A CA 1 ATOM 650 C C . THR A 1 85 ? 38.442 54.961 40.471 1.00 34.40 ? 151 THR A C 1 ATOM 651 O O . THR A 1 85 ? 39.273 54.266 41.038 1.00 32.84 ? 151 THR A O 1 ATOM 652 C CB . THR A 1 85 ? 38.127 56.899 42.080 1.00 39.71 ? 151 THR A CB 1 ATOM 653 O OG1 . THR A 1 85 ? 36.721 56.710 42.293 1.00 38.58 ? 151 THR A OG1 1 ATOM 654 C CG2 . THR A 1 85 ? 38.521 58.312 42.381 1.00 36.92 ? 151 THR A CG2 1 ATOM 655 N N . GLY A 1 86 ? 37.470 54.472 39.732 1.00 31.57 ? 152 GLY A N 1 ATOM 656 C CA . GLY A 1 86 ? 37.275 53.051 39.512 1.00 33.25 ? 152 GLY A CA 1 ATOM 657 C C . GLY A 1 86 ? 35.851 52.708 39.089 1.00 39.54 ? 152 GLY A C 1 ATOM 658 O O . GLY A 1 86 ? 35.044 53.599 38.848 1.00 39.05 ? 152 GLY A O 1 ATOM 659 N N . THR A 1 87 ? 35.542 51.413 38.986 1.00 36.41 ? 153 THR A N 1 ATOM 660 C CA . THR A 1 87 ? 34.240 50.894 38.575 1.00 35.06 ? 153 THR A CA 1 ATOM 661 C C . THR A 1 87 ? 33.682 49.983 39.646 1.00 38.76 ? 153 THR A C 1 ATOM 662 O O . THR A 1 87 ? 34.434 49.284 40.318 1.00 40.14 ? 153 THR A O 1 ATOM 663 C CB . THR A 1 87 ? 34.397 50.178 37.233 1.00 34.99 ? 153 THR A CB 1 ATOM 664 O OG1 . THR A 1 87 ? 34.914 51.125 36.330 1.00 46.88 ? 153 THR A OG1 1 ATOM 665 C CG2 . THR A 1 87 ? 33.105 49.629 36.666 1.00 26.03 ? 153 THR A CG2 1 ATOM 666 N N . VAL A 1 88 ? 32.361 50.053 39.852 1.00 33.03 ? 154 VAL A N 1 ATOM 667 C CA . VAL A 1 88 ? 31.591 49.162 40.721 1.00 29.40 ? 154 VAL A CA 1 ATOM 668 C C . VAL A 1 88 ? 30.509 48.605 39.858 1.00 29.09 ? 154 VAL A C 1 ATOM 669 O O . VAL A 1 88 ? 30.015 49.270 38.942 1.00 24.91 ? 154 VAL A O 1 ATOM 670 C CB . VAL A 1 88 ? 31.044 49.737 42.039 1.00 32.16 ? 154 VAL A CB 1 ATOM 671 C CG1 . VAL A 1 88 ? 32.163 50.043 43.013 1.00 31.74 ? 154 VAL A CG1 1 ATOM 672 C CG2 . VAL A 1 88 ? 30.129 50.935 41.813 1.00 31.89 ? 154 VAL A CG2 1 ATOM 673 N N . SER A 1 89 ? 30.133 47.382 40.139 1.00 27.49 ? 155 SER A N 1 ATOM 674 C CA . SER A 1 89 ? 29.117 46.726 39.343 1.00 27.45 ? 155 SER A CA 1 ATOM 675 C C . SER A 1 89 ? 28.205 45.865 40.238 1.00 29.74 ? 155 SER A C 1 ATOM 676 O O . SER A 1 89 ? 28.625 45.395 41.303 1.00 27.79 ? 155 SER A O 1 ATOM 677 C CB . SER A 1 89 ? 29.783 45.907 38.235 1.00 29.70 ? 155 SER A CB 1 ATOM 678 O OG . SER A 1 89 ? 28.810 45.393 37.352 1.00 46.19 ? 155 SER A OG 1 ATOM 679 N N . GLY A 1 90 ? 26.967 45.703 39.800 1.00 25.92 ? 156 GLY A N 1 ATOM 680 C CA . GLY A 1 90 ? 26.006 44.889 40.513 1.00 26.04 ? 156 GLY A CA 1 ATOM 681 C C . GLY A 1 90 ? 24.661 44.912 39.848 1.00 29.86 ? 156 GLY A C 1 ATOM 682 O O . GLY A 1 90 ? 24.583 44.898 38.628 1.00 29.67 ? 156 GLY A O 1 ATOM 683 N N . PHE A 1 91 ? 23.601 44.964 40.648 1.00 27.66 ? 157 PHE A N 1 ATOM 684 C CA . PHE A 1 91 ? 22.222 44.937 40.154 1.00 27.33 ? 157 PHE A CA 1 ATOM 685 C C . PHE A 1 91 ? 21.303 45.865 40.967 1.00 29.59 ? 157 PHE A C 1 ATOM 686 O O . PHE A 1 91 ? 21.605 46.193 42.107 1.00 27.76 ? 157 PHE A O 1 ATOM 687 C CB . PHE A 1 91 ? 21.673 43.479 40.136 1.00 28.81 ? 157 PHE A CB 1 ATOM 688 C CG . PHE A 1 91 ? 21.654 42.818 41.496 1.00 29.69 ? 157 PHE A CG 1 ATOM 689 C CD1 . PHE A 1 91 ? 20.569 42.982 42.353 1.00 30.45 ? 157 PHE A CD1 1 ATOM 690 C CD2 . PHE A 1 91 ? 22.738 42.063 41.936 1.00 30.26 ? 157 PHE A CD2 1 ATOM 691 C CE1 . PHE A 1 91 ? 20.573 42.407 43.625 1.00 30.23 ? 157 PHE A CE1 1 ATOM 692 C CE2 . PHE A 1 91 ? 22.723 41.461 43.198 1.00 32.07 ? 157 PHE A CE2 1 ATOM 693 C CZ . PHE A 1 91 ? 21.650 41.649 44.034 1.00 29.58 ? 157 PHE A CZ 1 ATOM 694 N N . LEU A 1 92 ? 20.168 46.232 40.380 1.00 28.24 ? 158 LEU A N 1 ATOM 695 C CA . LEU A 1 92 ? 19.148 47.099 40.967 1.00 28.77 ? 158 LEU A CA 1 ATOM 696 C C . LEU A 1 92 ? 18.236 46.352 41.959 1.00 33.06 ? 158 LEU A C 1 ATOM 697 O O . LEU A 1 92 ? 17.818 45.220 41.702 1.00 31.00 ? 158 LEU A O 1 ATOM 698 C CB . LEU A 1 92 ? 18.305 47.682 39.823 1.00 28.92 ? 158 LEU A CB 1 ATOM 699 C CG . LEU A 1 92 ? 18.600 49.108 39.342 1.00 32.60 ? 158 LEU A CG 1 ATOM 700 C CD1 . LEU A 1 92 ? 19.986 49.572 39.646 1.00 31.29 ? 158 LEU A CD1 1 ATOM 701 C CD2 . LEU A 1 92 ? 18.249 49.277 37.888 1.00 30.36 ? 158 LEU A CD2 1 ATOM 702 N N . SER A 1 93 ? 17.932 47.010 43.093 1.00 30.80 ? 159 SER A N 1 ATOM 703 C CA . SER A 1 93 ? 17.024 46.519 44.143 1.00 30.25 ? 159 SER A CA 1 ATOM 704 C C . SER A 1 93 ? 16.211 47.683 44.651 1.00 32.25 ? 159 SER A C 1 ATOM 705 O O . SER A 1 93 ? 16.624 48.821 44.493 1.00 31.87 ? 159 SER A O 1 ATOM 706 C CB . SER A 1 93 ? 17.800 45.884 45.298 1.00 31.09 ? 159 SER A CB 1 ATOM 707 O OG . SER A 1 93 ? 18.322 44.639 44.882 1.00 34.66 ? 159 SER A OG 1 ATOM 708 N N . GLN A 1 94 ? 15.056 47.419 45.256 1.00 29.77 ? 160 GLN A N 1 ATOM 709 C CA . GLN A 1 94 ? 14.240 48.495 45.823 1.00 28.55 ? 160 GLN A CA 1 ATOM 710 C C . GLN A 1 94 ? 13.945 48.193 47.271 1.00 32.46 ? 160 GLN A C 1 ATOM 711 O O . GLN A 1 94 ? 13.653 47.044 47.629 1.00 34.01 ? 160 GLN A O 1 ATOM 712 C CB . GLN A 1 94 ? 12.935 48.699 45.034 1.00 29.51 ? 160 GLN A CB 1 ATOM 713 C CG . GLN A 1 94 ? 12.072 49.839 45.578 1.00 34.23 ? 160 GLN A CG 1 ATOM 714 C CD . GLN A 1 94 ? 10.715 49.878 44.932 1.00 57.06 ? 160 GLN A CD 1 ATOM 715 O OE1 . GLN A 1 94 ? 10.491 50.652 44.013 1.00 50.00 ? 160 GLN A OE1 1 ATOM 716 N NE2 . GLN A 1 94 ? 9.780 49.064 45.403 1.00 52.02 ? 160 GLN A NE2 1 ATOM 717 N N . ASP A 1 95 ? 14.012 49.222 48.106 1.00 27.81 ? 161 ASP A N 1 ATOM 718 C CA . ASP A 1 95 ? 13.703 49.102 49.522 1.00 27.78 ? 161 ASP A CA 1 ATOM 719 C C . ASP A 1 95 ? 13.478 50.475 50.105 1.00 31.49 ? 161 ASP A C 1 ATOM 720 O O . ASP A 1 95 ? 13.625 51.481 49.409 1.00 30.24 ? 161 ASP A O 1 ATOM 721 C CB . ASP A 1 95 ? 14.819 48.346 50.277 1.00 29.53 ? 161 ASP A CB 1 ATOM 722 C CG . ASP A 1 95 ? 14.311 47.463 51.400 1.00 32.94 ? 161 ASP A CG 1 ATOM 723 O OD1 . ASP A 1 95 ? 13.331 47.856 52.067 1.00 31.68 ? 161 ASP A OD1 1 ATOM 724 O OD2 . ASP A 1 95 ? 14.946 46.423 51.669 1.00 31.97 ? 161 ASP A OD2 1 ATOM 725 N N . ILE A 1 96 ? 13.094 50.516 51.374 1.00 31.02 ? 162 ILE A N 1 ATOM 726 C CA . ILE A 1 96 ? 12.881 51.767 52.095 1.00 31.74 ? 162 ILE A CA 1 ATOM 727 C C . ILE A 1 96 ? 14.209 52.239 52.639 1.00 33.96 ? 162 ILE A C 1 ATOM 728 O O . ILE A 1 96 ? 14.931 51.462 53.266 1.00 34.00 ? 162 ILE A O 1 ATOM 729 C CB . ILE A 1 96 ? 11.797 51.610 53.188 1.00 35.05 ? 162 ILE A CB 1 ATOM 730 C CG1 . ILE A 1 96 ? 10.441 51.264 52.535 1.00 34.95 ? 162 ILE A CG1 1 ATOM 731 C CG2 . ILE A 1 96 ? 11.669 52.897 54.026 1.00 36.97 ? 162 ILE A CG2 1 ATOM 732 C CD1 . ILE A 1 96 ? 9.517 50.496 53.479 1.00 48.30 ? 162 ILE A CD1 1 ATOM 733 N N . ILE A 1 97 ? 14.547 53.504 52.363 1.00 30.71 ? 163 ILE A N 1 ATOM 734 C CA . ILE A 1 97 ? 15.780 54.139 52.851 1.00 29.18 ? 163 ILE A CA 1 ATOM 735 C C . ILE A 1 97 ? 15.425 55.268 53.825 1.00 34.06 ? 163 ILE A C 1 ATOM 736 O O . ILE A 1 97 ? 14.567 56.101 53.526 1.00 34.81 ? 163 ILE A O 1 ATOM 737 C CB . ILE A 1 97 ? 16.726 54.622 51.686 1.00 29.94 ? 163 ILE A CB 1 ATOM 738 C CG1 . ILE A 1 97 ? 17.173 53.423 50.798 1.00 28.89 ? 163 ILE A CG1 1 ATOM 739 C CG2 . ILE A 1 97 ? 17.933 55.402 52.240 1.00 27.63 ? 163 ILE A CG2 1 ATOM 740 C CD1 . ILE A 1 97 ? 18.236 53.737 49.657 1.00 25.11 ? 163 ILE A CD1 1 ATOM 741 N N . THR A 1 98 ? 16.083 55.290 54.984 1.00 31.35 ? 164 THR A N 1 ATOM 742 C CA . THR A 1 98 ? 15.913 56.379 55.957 1.00 31.78 ? 164 THR A CA 1 ATOM 743 C C . THR A 1 98 ? 17.162 57.245 55.931 1.00 36.09 ? 164 THR A C 1 ATOM 744 O O . THR A 1 98 ? 18.284 56.746 56.067 1.00 35.72 ? 164 THR A O 1 ATOM 745 C CB . THR A 1 98 ? 15.526 55.913 57.384 1.00 41.18 ? 164 THR A CB 1 ATOM 746 O OG1 . THR A 1 98 ? 16.654 55.340 58.046 1.00 46.02 ? 164 THR A OG1 1 ATOM 747 C CG2 . THR A 1 98 ? 14.363 54.943 57.412 1.00 37.13 ? 164 THR A CG2 1 ATOM 748 N N . VAL A 1 99 ? 16.965 58.521 55.628 1.00 32.87 ? 165 VAL A N 1 ATOM 749 C CA . VAL A 1 99 ? 18.023 59.514 55.580 1.00 32.54 ? 165 VAL A CA 1 ATOM 750 C C . VAL A 1 99 ? 17.568 60.701 56.427 1.00 40.35 ? 165 VAL A C 1 ATOM 751 O O . VAL A 1 99 ? 16.598 61.362 56.081 1.00 39.97 ? 165 VAL A O 1 ATOM 752 C CB . VAL A 1 99 ? 18.529 59.851 54.135 1.00 34.37 ? 165 VAL A CB 1 ATOM 753 C CG1 . VAL A 1 99 ? 17.396 60.095 53.172 1.00 34.09 ? 165 VAL A CG1 1 ATOM 754 C CG2 . VAL A 1 99 ? 19.506 61.016 54.119 1.00 33.73 ? 165 VAL A CG2 1 ATOM 755 N N . GLY A 1 100 ? 18.244 60.895 57.560 1.00 40.44 ? 166 GLY A N 1 ATOM 756 C CA . GLY A 1 100 ? 17.991 61.938 58.549 1.00 41.96 ? 166 GLY A CA 1 ATOM 757 C C . GLY A 1 100 ? 16.566 62.066 59.056 1.00 50.96 ? 166 GLY A C 1 ATOM 758 O O . GLY A 1 100 ? 16.149 63.179 59.388 1.00 52.98 ? 166 GLY A O 1 ATOM 759 N N . GLY A 1 101 ? 15.785 61.005 59.077 1.00 48.61 ? 167 GLY A N 1 ATOM 760 C CA . GLY A 1 101 ? 14.402 61.172 59.516 1.00 49.97 ? 167 GLY A CA 1 ATOM 761 C C . GLY A 1 101 ? 13.376 61.115 58.397 1.00 55.11 ? 167 GLY A C 1 ATOM 762 O O . GLY A 1 101 ? 12.189 60.869 58.652 1.00 55.69 ? 167 GLY A O 1 ATOM 763 N N . ILE A 1 102 ? 13.813 61.383 57.150 1.00 48.81 ? 168 ILE A N 1 ATOM 764 C CA . ILE A 1 102 ? 12.972 61.214 55.970 1.00 46.15 ? 168 ILE A CA 1 ATOM 765 C C . ILE A 1 102 ? 13.090 59.729 55.551 1.00 46.44 ? 168 ILE A C 1 ATOM 766 O O . ILE A 1 102 ? 14.178 59.169 55.558 1.00 46.30 ? 168 ILE A O 1 ATOM 767 C CB . ILE A 1 102 ? 13.394 62.159 54.837 1.00 48.38 ? 168 ILE A CB 1 ATOM 768 C CG1 . ILE A 1 102 ? 13.244 63.635 55.260 1.00 47.58 ? 168 ILE A CG1 1 ATOM 769 C CG2 . ILE A 1 102 ? 12.622 61.826 53.541 1.00 48.17 ? 168 ILE A CG2 1 ATOM 770 C CD1 . ILE A 1 102 ? 13.802 64.644 54.281 1.00 48.02 ? 168 ILE A CD1 1 ATOM 771 N N . THR A 1 103 ? 11.949 59.096 55.255 1.00 40.67 ? 169 THR A N 1 ATOM 772 C CA . THR A 1 103 ? 11.822 57.725 54.803 1.00 39.65 ? 169 THR A CA 1 ATOM 773 C C . THR A 1 103 ? 11.369 57.817 53.362 1.00 44.94 ? 169 THR A C 1 ATOM 774 O O . THR A 1 103 ? 10.386 58.497 53.073 1.00 46.14 ? 169 THR A O 1 ATOM 775 C CB . THR A 1 103 ? 10.814 57.006 55.696 1.00 47.36 ? 169 THR A CB 1 ATOM 776 O OG1 . THR A 1 103 ? 11.353 56.837 57.008 1.00 50.60 ? 169 THR A OG1 1 ATOM 777 C CG2 . THR A 1 103 ? 10.319 55.702 55.131 1.00 44.49 ? 169 THR A CG2 1 ATOM 778 N N . VAL A 1 104 ? 12.085 57.157 52.454 1.00 40.67 ? 170 VAL A N 1 ATOM 779 C CA . VAL A 1 104 ? 11.771 57.159 51.027 1.00 40.03 ? 170 VAL A CA 1 ATOM 780 C C . VAL A 1 104 ? 11.945 55.739 50.421 1.00 42.39 ? 170 VAL A C 1 ATOM 781 O O . VAL A 1 104 ? 12.880 55.027 50.774 1.00 43.25 ? 170 VAL A O 1 ATOM 782 C CB . VAL A 1 104 ? 12.585 58.271 50.270 1.00 44.37 ? 170 VAL A CB 1 ATOM 783 C CG1 . VAL A 1 104 ? 14.089 58.036 50.345 1.00 44.38 ? 170 VAL A CG1 1 ATOM 784 C CG2 . VAL A 1 104 ? 12.138 58.426 48.827 1.00 43.97 ? 170 VAL A CG2 1 ATOM 785 N N . THR A 1 105 ? 11.030 55.332 49.532 1.00 36.89 ? 171 THR A N 1 ATOM 786 C CA . THR A 1 105 ? 11.121 54.074 48.789 1.00 35.46 ? 171 THR A CA 1 ATOM 787 C C . THR A 1 105 ? 12.109 54.370 47.674 1.00 36.47 ? 171 THR A C 1 ATOM 788 O O . THR A 1 105 ? 11.887 55.296 46.896 1.00 36.70 ? 171 THR A O 1 ATOM 789 C CB . THR A 1 105 ? 9.739 53.613 48.317 1.00 39.55 ? 171 THR A CB 1 ATOM 790 O OG1 . THR A 1 105 ? 8.989 53.230 49.476 1.00 42.41 ? 171 THR A OG1 1 ATOM 791 C CG2 . THR A 1 105 ? 9.817 52.437 47.371 1.00 34.01 ? 171 THR A CG2 1 ATOM 792 N N . GLN A 1 106 ? 13.226 53.635 47.631 1.00 31.46 ? 172 GLN A N 1 ATOM 793 C CA . GLN A 1 106 ? 14.292 53.942 46.690 1.00 30.13 ? 172 GLN A CA 1 ATOM 794 C C . GLN A 1 106 ? 14.837 52.769 45.890 1.00 31.89 ? 172 GLN A C 1 ATOM 795 O O . GLN A 1 106 ? 15.092 51.704 46.445 1.00 30.65 ? 172 GLN A O 1 ATOM 796 C CB . GLN A 1 106 ? 15.435 54.629 47.474 1.00 30.81 ? 172 GLN A CB 1 ATOM 797 C CG . GLN A 1 106 ? 16.580 55.229 46.640 1.00 31.41 ? 172 GLN A CG 1 ATOM 798 C CD . GLN A 1 106 ? 16.116 56.304 45.692 1.00 42.83 ? 172 GLN A CD 1 ATOM 799 O OE1 . GLN A 1 106 ? 15.259 57.126 46.021 1.00 36.35 ? 172 GLN A OE1 1 ATOM 800 N NE2 . GLN A 1 106 ? 16.676 56.315 44.492 1.00 38.05 ? 172 GLN A NE2 1 ATOM 801 N N . MET A 1 107 ? 15.107 53.011 44.601 1.00 29.39 ? 173 MET A N 1 ATOM 802 C CA . MET A 1 107 ? 15.760 52.036 43.734 1.00 29.93 ? 173 MET A CA 1 ATOM 803 C C . MET A 1 107 ? 17.256 52.318 43.882 1.00 32.19 ? 173 MET A C 1 ATOM 804 O O . MET A 1 107 ? 17.721 53.459 43.702 1.00 29.36 ? 173 MET A O 1 ATOM 805 C CB . MET A 1 107 ? 15.289 52.120 42.277 1.00 32.15 ? 173 MET A CB 1 ATOM 806 C CG . MET A 1 107 ? 15.782 50.972 41.410 1.00 37.08 ? 173 MET A CG 1 ATOM 807 S SD . MET A 1 107 ? 14.969 49.366 41.696 1.00 43.58 ? 173 MET A SD 1 ATOM 808 C CE . MET A 1 107 ? 13.285 49.721 41.133 1.00 40.34 ? 173 MET A CE 1 ATOM 809 N N . PHE A 1 108 ? 17.992 51.284 44.292 1.00 26.42 ? 174 PHE A N 1 ATOM 810 C CA . PHE A 1 108 ? 19.420 51.427 44.539 1.00 25.46 ? 174 PHE A CA 1 ATOM 811 C C . PHE A 1 108 ? 20.162 50.235 43.966 1.00 27.95 ? 174 PHE A C 1 ATOM 812 O O . PHE A 1 108 ? 19.549 49.224 43.639 1.00 28.61 ? 174 PHE A O 1 ATOM 813 C CB . PHE A 1 108 ? 19.688 51.608 46.061 1.00 26.63 ? 174 PHE A CB 1 ATOM 814 C CG . PHE A 1 108 ? 19.383 50.392 46.911 1.00 26.77 ? 174 PHE A CG 1 ATOM 815 C CD1 . PHE A 1 108 ? 18.088 50.141 47.361 1.00 27.07 ? 174 PHE A CD1 1 ATOM 816 C CD2 . PHE A 1 108 ? 20.397 49.503 47.276 1.00 25.82 ? 174 PHE A CD2 1 ATOM 817 C CE1 . PHE A 1 108 ? 17.812 49.014 48.142 1.00 26.88 ? 174 PHE A CE1 1 ATOM 818 C CE2 . PHE A 1 108 ? 20.107 48.360 48.033 1.00 26.40 ? 174 PHE A CE2 1 ATOM 819 C CZ . PHE A 1 108 ? 18.826 48.138 48.478 1.00 23.88 ? 174 PHE A CZ 1 ATOM 820 N N . GLY A 1 109 ? 21.467 50.379 43.830 1.00 25.04 ? 175 GLY A N 1 ATOM 821 C CA . GLY A 1 109 ? 22.343 49.319 43.341 1.00 25.14 ? 175 GLY A CA 1 ATOM 822 C C . GLY A 1 109 ? 22.953 48.514 44.480 1.00 28.78 ? 175 GLY A C 1 ATOM 823 O O . GLY A 1 109 ? 23.455 49.074 45.474 1.00 27.12 ? 175 GLY A O 1 ATOM 824 N N . GLU A 1 110 ? 22.859 47.187 44.353 1.00 25.16 ? 176 GLU A N 1 ATOM 825 C CA . GLU A 1 110 ? 23.451 46.189 45.254 1.00 25.52 ? 176 GLU A CA 1 ATOM 826 C C . GLU A 1 110 ? 24.761 45.786 44.555 1.00 28.69 ? 176 GLU A C 1 ATOM 827 O O . GLU A 1 110 ? 24.743 45.090 43.520 1.00 28.03 ? 176 GLU A O 1 ATOM 828 C CB . GLU A 1 110 ? 22.510 44.971 45.400 1.00 26.78 ? 176 GLU A CB 1 ATOM 829 C CG . GLU A 1 110 ? 21.459 45.065 46.503 1.00 31.63 ? 176 GLU A CG 1 ATOM 830 C CD . GLU A 1 110 ? 20.956 43.701 46.958 1.00 43.00 ? 176 GLU A CD 1 ATOM 831 O OE1 . GLU A 1 110 ? 21.786 42.890 47.417 1.00 33.12 ? 176 GLU A OE1 1 ATOM 832 O OE2 . GLU A 1 110 ? 19.750 43.413 46.801 1.00 35.64 ? 176 GLU A OE2 1 ATOM 833 N N . VAL A 1 111 ? 25.893 46.312 45.046 1.00 25.76 ? 177 VAL A N 1 ATOM 834 C CA . VAL A 1 111 ? 27.192 46.100 44.385 1.00 24.48 ? 177 VAL A CA 1 ATOM 835 C C . VAL A 1 111 ? 27.791 44.714 44.712 1.00 30.51 ? 177 VAL A C 1 ATOM 836 O O . VAL A 1 111 ? 27.939 44.335 45.874 1.00 30.62 ? 177 VAL A O 1 ATOM 837 C CB . VAL A 1 111 ? 28.153 47.289 44.644 1.00 25.37 ? 177 VAL A CB 1 ATOM 838 C CG1 . VAL A 1 111 ? 29.626 46.894 44.523 1.00 24.12 ? 177 VAL A CG1 1 ATOM 839 C CG2 . VAL A 1 111 ? 27.817 48.438 43.695 1.00 24.15 ? 177 VAL A CG2 1 ATOM 840 N N . THR A 1 112 ? 28.104 43.957 43.662 1.00 27.84 ? 178 THR A N 1 ATOM 841 C CA . THR A 1 112 ? 28.683 42.618 43.804 1.00 28.00 ? 178 THR A CA 1 ATOM 842 C C . THR A 1 112 ? 30.138 42.575 43.313 1.00 32.93 ? 178 THR A C 1 ATOM 843 O O . THR A 1 112 ? 30.796 41.553 43.483 1.00 34.59 ? 178 THR A O 1 ATOM 844 C CB . THR A 1 112 ? 27.775 41.566 43.133 1.00 31.26 ? 178 THR A CB 1 ATOM 845 O OG1 . THR A 1 112 ? 27.649 41.913 41.755 1.00 30.04 ? 178 THR A OG1 1 ATOM 846 C CG2 . THR A 1 112 ? 26.370 41.483 43.783 1.00 24.16 ? 178 THR A CG2 1 ATOM 847 N N . GLU A 1 113 ? 30.650 43.681 42.717 1.00 27.26 ? 179 GLU A N 1 ATOM 848 C CA . GLU A 1 113 ? 32.025 43.775 42.203 1.00 26.05 ? 179 GLU A CA 1 ATOM 849 C C . GLU A 1 113 ? 32.596 45.064 42.673 1.00 28.82 ? 179 GLU A C 1 ATOM 850 O O . GLU A 1 113 ? 32.223 46.128 42.186 1.00 25.11 ? 179 GLU A O 1 ATOM 851 C CB . GLU A 1 113 ? 32.104 43.615 40.676 1.00 27.26 ? 179 GLU A CB 1 ATOM 852 C CG . GLU A 1 113 ? 31.400 42.346 40.192 1.00 36.36 ? 179 GLU A CG 1 ATOM 853 C CD . GLU A 1 113 ? 31.528 41.972 38.734 1.00 65.08 ? 179 GLU A CD 1 ATOM 854 O OE1 . GLU A 1 113 ? 31.185 42.809 37.871 1.00 68.16 ? 179 GLU A OE1 1 ATOM 855 O OE2 . GLU A 1 113 ? 31.914 40.814 38.455 1.00 73.87 ? 179 GLU A OE2 1 ATOM 856 N N . MET A 1 114 ? 33.445 44.955 43.715 1.00 28.41 ? 180 MET A N 1 ATOM 857 C CA . MET A 1 114 ? 34.022 46.080 44.439 1.00 28.53 ? 180 MET A CA 1 ATOM 858 C C . MET A 1 114 ? 35.553 45.981 44.501 1.00 30.95 ? 180 MET A C 1 ATOM 859 O O . MET A 1 114 ? 36.078 45.350 45.412 1.00 31.15 ? 180 MET A O 1 ATOM 860 C CB . MET A 1 114 ? 33.408 46.106 45.837 1.00 31.13 ? 180 MET A CB 1 ATOM 861 C CG . MET A 1 114 ? 33.231 47.478 46.385 1.00 35.59 ? 180 MET A CG 1 ATOM 862 S SD . MET A 1 114 ? 32.619 47.375 48.077 1.00 39.75 ? 180 MET A SD 1 ATOM 863 C CE . MET A 1 114 ? 32.648 48.994 48.466 1.00 37.09 ? 180 MET A CE 1 ATOM 864 N N . PRO A 1 115 ? 36.273 46.620 43.545 1.00 27.22 ? 181 PRO A N 1 ATOM 865 C CA . PRO A 1 115 ? 37.745 46.538 43.508 1.00 26.48 ? 181 PRO A CA 1 ATOM 866 C C . PRO A 1 115 ? 38.465 47.040 44.756 1.00 33.50 ? 181 PRO A C 1 ATOM 867 O O . PRO A 1 115 ? 38.131 48.106 45.281 1.00 34.38 ? 181 PRO A O 1 ATOM 868 C CB . PRO A 1 115 ? 38.113 47.362 42.268 1.00 27.59 ? 181 PRO A CB 1 ATOM 869 C CG . PRO A 1 115 ? 36.900 47.351 41.430 1.00 32.73 ? 181 PRO A CG 1 ATOM 870 C CD . PRO A 1 115 ? 35.762 47.396 42.399 1.00 28.98 ? 181 PRO A CD 1 ATOM 871 N N . ALA A 1 116 ? 39.459 46.255 45.235 1.00 31.92 ? 182 ALA A N 1 ATOM 872 C CA . ALA A 1 116 ? 40.270 46.568 46.417 1.00 31.65 ? 182 ALA A CA 1 ATOM 873 C C . ALA A 1 116 ? 40.885 47.942 46.278 1.00 35.53 ? 182 ALA A C 1 ATOM 874 O O . ALA A 1 116 ? 41.037 48.655 47.273 1.00 35.29 ? 182 ALA A O 1 ATOM 875 C CB . ALA A 1 116 ? 41.353 45.517 46.594 1.00 32.57 ? 182 ALA A CB 1 ATOM 876 N N . LEU A 1 117 ? 41.217 48.326 45.031 1.00 34.39 ? 183 LEU A N 1 ATOM 877 C CA . LEU A 1 117 ? 41.719 49.657 44.707 1.00 35.84 ? 183 LEU A CA 1 ATOM 878 C C . LEU A 1 117 ? 40.606 50.342 43.940 1.00 37.51 ? 183 LEU A C 1 ATOM 879 O O . LEU A 1 117 ? 40.233 49.848 42.884 1.00 37.28 ? 183 LEU A O 1 ATOM 880 C CB . LEU A 1 117 ? 43.011 49.592 43.888 1.00 37.33 ? 183 LEU A CB 1 ATOM 881 C CG . LEU A 1 117 ? 44.285 49.956 44.655 1.00 44.73 ? 183 LEU A CG 1 ATOM 882 C CD1 . LEU A 1 117 ? 45.497 49.144 44.149 1.00 45.08 ? 183 LEU A CD1 1 ATOM 883 C CD2 . LEU A 1 117 ? 44.564 51.468 44.545 1.00 51.57 ? 183 LEU A CD2 1 ATOM 884 N N . PRO A 1 118 ? 39.920 51.351 44.510 1.00 32.24 ? 184 PRO A N 1 ATOM 885 C CA . PRO A 1 118 ? 40.231 52.072 45.767 1.00 30.79 ? 184 PRO A CA 1 ATOM 886 C C . PRO A 1 118 ? 39.453 51.682 47.027 1.00 33.69 ? 184 PRO A C 1 ATOM 887 O O . PRO A 1 118 ? 39.782 52.162 48.114 1.00 33.84 ? 184 PRO A O 1 ATOM 888 C CB . PRO A 1 118 ? 39.857 53.512 45.391 1.00 31.71 ? 184 PRO A CB 1 ATOM 889 C CG . PRO A 1 118 ? 38.606 53.336 44.510 1.00 36.30 ? 184 PRO A CG 1 ATOM 890 C CD . PRO A 1 118 ? 38.835 52.028 43.752 1.00 32.60 ? 184 PRO A CD 1 ATOM 891 N N . PHE A 1 119 ? 38.423 50.844 46.893 1.00 29.33 ? 185 PHE A N 1 ATOM 892 C CA . PHE A 1 119 ? 37.454 50.577 47.951 1.00 28.94 ? 185 PHE A CA 1 ATOM 893 C C . PHE A 1 119 ? 38.015 49.972 49.253 1.00 32.15 ? 185 PHE A C 1 ATOM 894 O O . PHE A 1 119 ? 37.337 50.108 50.262 1.00 31.03 ? 185 PHE A O 1 ATOM 895 C CB . PHE A 1 119 ? 36.253 49.788 47.410 1.00 30.68 ? 185 PHE A CB 1 ATOM 896 C CG . PHE A 1 119 ? 35.549 50.653 46.379 1.00 30.93 ? 185 PHE A CG 1 ATOM 897 C CD1 . PHE A 1 119 ? 34.826 51.776 46.768 1.00 30.95 ? 185 PHE A CD1 1 ATOM 898 C CD2 . PHE A 1 119 ? 35.715 50.416 45.020 1.00 31.69 ? 185 PHE A CD2 1 ATOM 899 C CE1 . PHE A 1 119 ? 34.228 52.613 45.819 1.00 31.85 ? 185 PHE A CE1 1 ATOM 900 C CE2 . PHE A 1 119 ? 35.133 51.267 44.071 1.00 34.33 ? 185 PHE A CE2 1 ATOM 901 C CZ . PHE A 1 119 ? 34.397 52.365 44.476 1.00 31.72 ? 185 PHE A CZ 1 ATOM 902 N N . MET A 1 120 ? 39.265 49.457 49.289 1.00 28.25 ? 186 MET A N 1 ATOM 903 C CA . MET A 1 120 ? 39.857 48.996 50.559 1.00 27.58 ? 186 MET A CA 1 ATOM 904 C C . MET A 1 120 ? 40.324 50.226 51.389 1.00 30.54 ? 186 MET A C 1 ATOM 905 O O . MET A 1 120 ? 40.517 50.111 52.603 1.00 27.93 ? 186 MET A O 1 ATOM 906 C CB . MET A 1 120 ? 41.010 47.995 50.342 1.00 30.24 ? 186 MET A CB 1 ATOM 907 C CG . MET A 1 120 ? 40.552 46.555 50.242 1.00 35.60 ? 186 MET A CG 1 ATOM 908 S SD . MET A 1 120 ? 39.724 45.837 51.704 1.00 41.64 ? 186 MET A SD 1 ATOM 909 C CE . MET A 1 120 ? 41.099 45.634 52.825 1.00 38.05 ? 186 MET A CE 1 ATOM 910 N N . LEU A 1 121 ? 40.458 51.417 50.730 1.00 27.59 ? 187 LEU A N 1 ATOM 911 C CA . LEU A 1 121 ? 40.832 52.681 51.381 1.00 27.27 ? 187 LEU A CA 1 ATOM 912 C C . LEU A 1 121 ? 39.598 53.463 51.870 1.00 29.82 ? 187 LEU A C 1 ATOM 913 O O . LEU A 1 121 ? 39.730 54.450 52.601 1.00 27.63 ? 187 LEU A O 1 ATOM 914 C CB . LEU A 1 121 ? 41.699 53.545 50.456 1.00 27.73 ? 187 LEU A CB 1 ATOM 915 C CG . LEU A 1 121 ? 42.997 52.889 49.969 1.00 33.37 ? 187 LEU A CG 1 ATOM 916 C CD1 . LEU A 1 121 ? 43.821 53.832 49.134 1.00 33.30 ? 187 LEU A CD1 1 ATOM 917 C CD2 . LEU A 1 121 ? 43.818 52.419 51.143 1.00 34.42 ? 187 LEU A CD2 1 ATOM 918 N N . ALA A 1 122 ? 38.406 52.984 51.488 1.00 25.81 ? 188 ALA A N 1 ATOM 919 C CA . ALA A 1 122 ? 37.128 53.600 51.819 1.00 25.29 ? 188 ALA A CA 1 ATOM 920 C C . ALA A 1 122 ? 36.675 53.259 53.234 1.00 29.64 ? 188 ALA A C 1 ATOM 921 O O . ALA A 1 122 ? 36.641 52.088 53.624 1.00 27.26 ? 188 ALA A O 1 ATOM 922 C CB . ALA A 1 122 ? 36.066 53.169 50.810 1.00 25.82 ? 188 ALA A CB 1 ATOM 923 N N . GLU A 1 123 ? 36.349 54.312 54.002 1.00 28.94 ? 189 GLU A N 1 ATOM 924 C CA . GLU A 1 123 ? 35.793 54.217 55.348 1.00 29.06 ? 189 GLU A CA 1 ATOM 925 C C . GLU A 1 123 ? 34.287 54.100 55.258 1.00 32.63 ? 189 GLU A C 1 ATOM 926 O O . GLU A 1 123 ? 33.648 53.587 56.167 1.00 37.46 ? 189 GLU A O 1 ATOM 927 C CB . GLU A 1 123 ? 36.163 55.436 56.194 1.00 30.61 ? 189 GLU A CB 1 ATOM 928 C CG . GLU A 1 123 ? 37.556 55.301 56.759 1.00 46.11 ? 189 GLU A CG 1 ATOM 929 C CD . GLU A 1 123 ? 37.737 54.217 57.808 1.00 72.62 ? 189 GLU A CD 1 ATOM 930 O OE1 . GLU A 1 123 ? 36.795 53.985 58.600 1.00 57.80 ? 189 GLU A OE1 1 ATOM 931 O OE2 . GLU A 1 123 ? 38.821 53.595 57.834 1.00 76.32 ? 189 GLU A OE2 1 ATOM 932 N N . PHE A 1 124 ? 33.730 54.573 54.172 1.00 24.99 ? 190 PHE A N 1 ATOM 933 C CA . PHE A 1 124 ? 32.311 54.479 53.896 1.00 24.70 ? 190 PHE A CA 1 ATOM 934 C C . PHE A 1 124 ? 32.059 53.135 53.229 1.00 30.29 ? 190 PHE A C 1 ATOM 935 O O . PHE A 1 124 ? 32.993 52.526 52.665 1.00 29.37 ? 190 PHE A O 1 ATOM 936 C CB . PHE A 1 124 ? 31.882 55.644 52.959 1.00 25.66 ? 190 PHE A CB 1 ATOM 937 C CG . PHE A 1 124 ? 32.661 55.755 51.661 1.00 26.00 ? 190 PHE A CG 1 ATOM 938 C CD1 . PHE A 1 124 ? 33.809 56.533 51.584 1.00 27.48 ? 190 PHE A CD1 1 ATOM 939 C CD2 . PHE A 1 124 ? 32.215 55.120 50.500 1.00 26.14 ? 190 PHE A CD2 1 ATOM 940 C CE1 . PHE A 1 124 ? 34.529 56.635 50.377 1.00 27.53 ? 190 PHE A CE1 1 ATOM 941 C CE2 . PHE A 1 124 ? 32.919 55.243 49.290 1.00 28.75 ? 190 PHE A CE2 1 ATOM 942 C CZ . PHE A 1 124 ? 34.067 56.009 49.234 1.00 27.50 ? 190 PHE A CZ 1 ATOM 943 N N . ASP A 1 125 ? 30.789 52.703 53.231 1.00 26.48 ? 191 ASP A N 1 ATOM 944 C CA . ASP A 1 125 ? 30.362 51.474 52.560 1.00 25.17 ? 191 ASP A CA 1 ATOM 945 C C . ASP A 1 125 ? 29.887 51.747 51.154 1.00 27.96 ? 191 ASP A C 1 ATOM 946 O O . ASP A 1 125 ? 30.241 51.019 50.227 1.00 29.00 ? 191 ASP A O 1 ATOM 947 C CB . ASP A 1 125 ? 29.270 50.744 53.367 1.00 25.79 ? 191 ASP A CB 1 ATOM 948 C CG . ASP A 1 125 ? 29.664 50.490 54.809 1.00 25.88 ? 191 ASP A CG 1 ATOM 949 O OD1 . ASP A 1 125 ? 30.650 49.746 55.034 1.00 28.55 ? 191 ASP A OD1 1 ATOM 950 O OD2 . ASP A 1 125 ? 29.008 51.045 55.707 1.00 25.60 ? 191 ASP A OD2 1 ATOM 951 N N . GLY A 1 126 ? 29.096 52.793 50.992 1.00 24.43 ? 192 GLY A N 1 ATOM 952 C CA . GLY A 1 126 ? 28.498 53.098 49.701 1.00 24.29 ? 192 GLY A CA 1 ATOM 953 C C . GLY A 1 126 ? 28.344 54.560 49.395 1.00 29.09 ? 192 GLY A C 1 ATOM 954 O O . GLY A 1 126 ? 29.007 55.414 49.998 1.00 27.72 ? 192 GLY A O 1 ATOM 955 N N . VAL A 1 127 ? 27.497 54.846 48.402 1.00 27.38 ? 193 VAL A N 1 ATOM 956 C CA . VAL A 1 127 ? 27.332 56.212 47.896 1.00 26.52 ? 193 VAL A CA 1 ATOM 957 C C . VAL A 1 127 ? 25.868 56.596 47.717 1.00 27.84 ? 193 VAL A C 1 ATOM 958 O O . VAL A 1 127 ? 25.076 55.800 47.243 1.00 27.43 ? 193 VAL A O 1 ATOM 959 C CB . VAL A 1 127 ? 28.164 56.423 46.577 1.00 28.07 ? 193 VAL A CB 1 ATOM 960 C CG1 . VAL A 1 127 ? 27.880 57.783 45.923 1.00 26.90 ? 193 VAL A CG1 1 ATOM 961 C CG2 . VAL A 1 127 ? 29.673 56.239 46.816 1.00 26.65 ? 193 VAL A CG2 1 ATOM 962 N N . VAL A 1 128 ? 25.544 57.829 48.081 1.00 23.56 ? 194 VAL A N 1 ATOM 963 C CA . VAL A 1 128 ? 24.251 58.457 47.864 1.00 23.48 ? 194 VAL A CA 1 ATOM 964 C C . VAL A 1 128 ? 24.480 59.582 46.830 1.00 27.03 ? 194 VAL A C 1 ATOM 965 O O . VAL A 1 128 ? 25.010 60.636 47.166 1.00 27.45 ? 194 VAL A O 1 ATOM 966 C CB . VAL A 1 128 ? 23.544 58.951 49.162 1.00 25.65 ? 194 VAL A CB 1 ATOM 967 C CG1 . VAL A 1 128 ? 22.309 59.785 48.829 1.00 24.48 ? 194 VAL A CG1 1 ATOM 968 C CG2 . VAL A 1 128 ? 23.167 57.772 50.055 1.00 24.86 ? 194 VAL A CG2 1 ATOM 969 N N . GLY A 1 129 ? 24.130 59.302 45.580 1.00 23.42 ? 195 GLY A N 1 ATOM 970 C CA . GLY A 1 129 ? 24.224 60.267 44.502 1.00 24.13 ? 195 GLY A CA 1 ATOM 971 C C . GLY A 1 129 ? 23.233 61.404 44.685 1.00 29.55 ? 195 GLY A C 1 ATOM 972 O O . GLY A 1 129 ? 22.026 61.168 44.801 1.00 30.05 ? 195 GLY A O 1 ATOM 973 N N . MET A 1 130 ? 23.762 62.637 44.758 1.00 25.51 ? 196 MET A N 1 ATOM 974 C CA . MET A 1 130 ? 23.040 63.897 44.938 1.00 24.52 ? 196 MET A CA 1 ATOM 975 C C . MET A 1 130 ? 22.952 64.657 43.607 1.00 28.42 ? 196 MET A C 1 ATOM 976 O O . MET A 1 130 ? 22.452 65.789 43.575 1.00 27.91 ? 196 MET A O 1 ATOM 977 C CB . MET A 1 130 ? 23.705 64.776 46.038 1.00 26.63 ? 196 MET A CB 1 ATOM 978 C CG . MET A 1 130 ? 23.649 64.206 47.456 1.00 29.56 ? 196 MET A CG 1 ATOM 979 S SD . MET A 1 130 ? 22.034 63.668 48.023 1.00 34.19 ? 196 MET A SD 1 ATOM 980 C CE . MET A 1 130 ? 21.227 65.252 48.327 1.00 31.33 ? 196 MET A CE 1 ATOM 981 N N . GLY A 1 131 ? 23.409 64.013 42.522 1.00 25.22 ? 197 GLY A N 1 ATOM 982 C CA . GLY A 1 131 ? 23.358 64.541 41.162 1.00 25.53 ? 197 GLY A CA 1 ATOM 983 C C . GLY A 1 131 ? 21.962 64.434 40.552 1.00 33.86 ? 197 GLY A C 1 ATOM 984 O O . GLY A 1 131 ? 21.048 63.853 41.152 1.00 33.45 ? 197 GLY A O 1 ATOM 985 N N . PHE A 1 132 ? 21.783 65.001 39.355 1.00 32.21 ? 198 PHE A N 1 ATOM 986 C CA . PHE A 1 132 ? 20.503 65.006 38.641 1.00 33.36 ? 198 PHE A CA 1 ATOM 987 C C . PHE A 1 132 ? 20.205 63.669 37.927 1.00 40.63 ? 198 PHE A C 1 ATOM 988 O O . PHE A 1 132 ? 21.128 62.908 37.640 1.00 39.90 ? 198 PHE A O 1 ATOM 989 C CB . PHE A 1 132 ? 20.518 66.139 37.612 1.00 34.91 ? 198 PHE A CB 1 ATOM 990 C CG . PHE A 1 132 ? 20.579 67.555 38.154 1.00 35.28 ? 198 PHE A CG 1 ATOM 991 C CD1 . PHE A 1 132 ? 21.787 68.114 38.558 1.00 35.94 ? 198 PHE A CD1 1 ATOM 992 C CD2 . PHE A 1 132 ? 19.436 68.348 38.201 1.00 36.19 ? 198 PHE A CD2 1 ATOM 993 C CE1 . PHE A 1 132 ? 21.855 69.435 38.996 1.00 36.36 ? 198 PHE A CE1 1 ATOM 994 C CE2 . PHE A 1 132 ? 19.503 69.667 38.665 1.00 37.96 ? 198 PHE A CE2 1 ATOM 995 C CZ . PHE A 1 132 ? 20.709 70.198 39.066 1.00 36.14 ? 198 PHE A CZ 1 ATOM 996 N N . ILE A 1 133 ? 18.922 63.418 37.591 1.00 39.69 ? 199 ILE A N 1 ATOM 997 C CA . ILE A 1 133 ? 18.442 62.223 36.869 1.00 40.17 ? 199 ILE A CA 1 ATOM 998 C C . ILE A 1 133 ? 19.106 62.060 35.488 1.00 44.43 ? 199 ILE A C 1 ATOM 999 O O . ILE A 1 133 ? 19.321 60.929 35.038 1.00 45.31 ? 199 ILE A O 1 ATOM 1000 C CB . ILE A 1 133 ? 16.887 62.182 36.786 1.00 44.14 ? 199 ILE A CB 1 ATOM 1001 C CG1 . ILE A 1 133 ? 16.370 60.763 36.410 1.00 44.28 ? 199 ILE A CG1 1 ATOM 1002 C CG2 . ILE A 1 133 ? 16.322 63.283 35.868 1.00 45.34 ? 199 ILE A CG2 1 ATOM 1003 C CD1 . ILE A 1 133 ? 14.896 60.479 36.761 1.00 50.03 ? 199 ILE A CD1 1 ATOM 1004 N N . GLU A 1 134 ? 19.474 63.180 34.846 1.00 39.43 ? 200 GLU A N 1 ATOM 1005 C CA . GLU A 1 134 ? 20.140 63.195 33.537 1.00 38.97 ? 200 GLU A CA 1 ATOM 1006 C C . GLU A 1 134 ? 21.444 62.366 33.534 1.00 44.67 ? 200 GLU A C 1 ATOM 1007 O O . GLU A 1 134 ? 21.823 61.841 32.488 1.00 46.36 ? 200 GLU A O 1 ATOM 1008 C CB . GLU A 1 134 ? 20.420 64.648 33.087 1.00 39.83 ? 200 GLU A CB 1 ATOM 1009 C CG . GLU A 1 134 ? 19.180 65.483 32.760 1.00 46.59 ? 200 GLU A CG 1 ATOM 1010 C CD . GLU A 1 134 ? 18.468 66.221 33.885 1.00 61.84 ? 200 GLU A CD 1 ATOM 1011 O OE1 . GLU A 1 134 ? 18.549 65.777 35.051 1.00 57.44 ? 200 GLU A OE1 1 ATOM 1012 O OE2 . GLU A 1 134 ? 17.758 67.207 33.584 1.00 62.95 ? 200 GLU A OE2 1 ATOM 1013 N N . GLN A 1 135 ? 22.125 62.253 34.700 1.00 39.56 ? 201 GLN A N 1 ATOM 1014 C CA . GLN A 1 135 ? 23.390 61.524 34.831 1.00 38.10 ? 201 GLN A CA 1 ATOM 1015 C C . GLN A 1 135 ? 23.256 60.209 35.599 1.00 39.65 ? 201 GLN A C 1 ATOM 1016 O O . GLN A 1 135 ? 24.272 59.572 35.910 1.00 38.82 ? 201 GLN A O 1 ATOM 1017 C CB . GLN A 1 135 ? 24.464 62.402 35.490 1.00 39.69 ? 201 GLN A CB 1 ATOM 1018 C CG . GLN A 1 135 ? 24.604 63.777 34.892 1.00 46.93 ? 201 GLN A CG 1 ATOM 1019 C CD . GLN A 1 135 ? 25.722 63.860 33.930 1.00 72.07 ? 201 GLN A CD 1 ATOM 1020 O OE1 . GLN A 1 135 ? 25.539 63.673 32.724 1.00 72.04 ? 201 GLN A OE1 1 ATOM 1021 N NE2 . GLN A 1 135 ? 26.893 64.185 34.458 1.00 66.00 ? 201 GLN A NE2 1 ATOM 1022 N N . ALA A 1 136 ? 22.006 59.795 35.888 1.00 36.17 ? 202 ALA A N 1 ATOM 1023 C CA . ALA A 1 136 ? 21.710 58.552 36.589 1.00 34.99 ? 202 ALA A CA 1 ATOM 1024 C C . ALA A 1 136 ? 21.842 57.368 35.640 1.00 40.93 ? 202 ALA A C 1 ATOM 1025 O O . ALA A 1 136 ? 21.255 57.376 34.551 1.00 43.41 ? 202 ALA A O 1 ATOM 1026 C CB . ALA A 1 136 ? 20.324 58.619 37.198 1.00 34.90 ? 202 ALA A CB 1 ATOM 1027 N N . ILE A 1 137 ? 22.676 56.376 36.016 1.00 36.70 ? 203 ILE A N 1 ATOM 1028 C CA . ILE A 1 137 ? 22.898 55.162 35.213 1.00 35.62 ? 203 ILE A CA 1 ATOM 1029 C C . ILE A 1 137 ? 21.659 54.276 35.347 1.00 39.16 ? 203 ILE A C 1 ATOM 1030 O O . ILE A 1 137 ? 21.116 54.138 36.445 1.00 38.73 ? 203 ILE A O 1 ATOM 1031 C CB . ILE A 1 137 ? 24.252 54.435 35.590 1.00 38.14 ? 203 ILE A CB 1 ATOM 1032 C CG1 . ILE A 1 137 ? 25.489 55.391 35.519 1.00 37.34 ? 203 ILE A CG1 1 ATOM 1033 C CG2 . ILE A 1 137 ? 24.500 53.151 34.783 1.00 37.63 ? 203 ILE A CG2 1 ATOM 1034 C CD1 . ILE A 1 137 ? 25.755 56.110 34.168 1.00 39.83 ? 203 ILE A CD1 1 ATOM 1035 N N . GLY A 1 138 ? 21.188 53.751 34.218 1.00 37.08 ? 204 GLY A N 1 ATOM 1036 C CA . GLY A 1 138 ? 19.984 52.924 34.157 1.00 36.63 ? 204 GLY A CA 1 ATOM 1037 C C . GLY A 1 138 ? 18.702 53.721 34.302 1.00 41.87 ? 204 GLY A C 1 ATOM 1038 O O . GLY A 1 138 ? 17.627 53.144 34.493 1.00 39.82 ? 204 GLY A O 1 ATOM 1039 N N . ARG A 1 139 ? 18.813 55.074 34.207 1.00 42.25 ? 205 ARG A N 1 ATOM 1040 C CA . ARG A 1 139 ? 17.722 56.050 34.331 1.00 43.12 ? 205 ARG A CA 1 ATOM 1041 C C . ARG A 1 139 ? 16.908 55.854 35.635 1.00 47.09 ? 205 ARG A C 1 ATOM 1042 O O . ARG A 1 139 ? 15.675 55.993 35.659 1.00 48.45 ? 205 ARG A O 1 ATOM 1043 C CB . ARG A 1 139 ? 16.828 56.074 33.072 1.00 46.69 ? 205 ARG A CB 1 ATOM 1044 C CG . ARG A 1 139 ? 17.577 56.206 31.750 1.00 61.24 ? 205 ARG A CG 1 ATOM 1045 C CD . ARG A 1 139 ? 16.674 55.949 30.538 1.00 79.18 ? 205 ARG A CD 1 ATOM 1046 N NE . ARG A 1 139 ? 15.939 54.675 30.598 1.00 89.63 ? 205 ARG A NE 1 ATOM 1047 C CZ . ARG A 1 139 ? 16.437 53.485 30.262 1.00 107.23 ? 205 ARG A CZ 1 ATOM 1048 N NH1 . ARG A 1 139 ? 17.696 53.373 29.852 1.00 96.64 ? 205 ARG A NH1 1 ATOM 1049 N NH2 . ARG A 1 139 ? 15.683 52.398 30.345 1.00 95.61 ? 205 ARG A NH2 1 ATOM 1050 N N . VAL A 1 140 ? 17.625 55.535 36.725 1.00 41.35 ? 206 VAL A N 1 ATOM 1051 C CA . VAL A 1 140 ? 17.040 55.325 38.050 1.00 39.67 ? 206 VAL A CA 1 ATOM 1052 C C . VAL A 1 140 ? 16.744 56.694 38.671 1.00 42.09 ? 206 VAL A C 1 ATOM 1053 O O . VAL A 1 140 ? 17.615 57.566 38.652 1.00 41.34 ? 206 VAL A O 1 ATOM 1054 C CB . VAL A 1 140 ? 17.975 54.455 38.940 1.00 41.22 ? 206 VAL A CB 1 ATOM 1055 C CG1 . VAL A 1 140 ? 17.398 54.263 40.330 1.00 40.27 ? 206 VAL A CG1 1 ATOM 1056 C CG2 . VAL A 1 140 ? 18.239 53.108 38.295 1.00 40.49 ? 206 VAL A CG2 1 ATOM 1057 N N . THR A 1 141 ? 15.535 56.886 39.221 1.00 38.49 ? 207 THR A N 1 ATOM 1058 C CA . THR A 1 141 ? 15.198 58.155 39.872 1.00 38.48 ? 207 THR A CA 1 ATOM 1059 C C . THR A 1 141 ? 16.113 58.412 41.111 1.00 42.92 ? 207 THR A C 1 ATOM 1060 O O . THR A 1 141 ? 16.124 57.596 42.043 1.00 42.56 ? 207 THR A O 1 ATOM 1061 C CB . THR A 1 141 ? 13.707 58.226 40.214 1.00 44.35 ? 207 THR A CB 1 ATOM 1062 O OG1 . THR A 1 141 ? 12.946 57.907 39.049 1.00 47.28 ? 207 THR A OG1 1 ATOM 1063 C CG2 . THR A 1 141 ? 13.304 59.599 40.754 1.00 40.24 ? 207 THR A CG2 1 ATOM 1064 N N . PRO A 1 142 ? 16.900 59.513 41.121 1.00 38.53 ? 208 PRO A N 1 ATOM 1065 C CA . PRO A 1 142 ? 17.765 59.796 42.278 1.00 37.72 ? 208 PRO A CA 1 ATOM 1066 C C . PRO A 1 142 ? 16.964 60.055 43.549 1.00 40.20 ? 208 PRO A C 1 ATOM 1067 O O . PRO A 1 142 ? 15.818 60.509 43.472 1.00 40.67 ? 208 PRO A O 1 ATOM 1068 C CB . PRO A 1 142 ? 18.531 61.055 41.843 1.00 38.87 ? 208 PRO A CB 1 ATOM 1069 C CG . PRO A 1 142 ? 18.456 61.054 40.369 1.00 42.44 ? 208 PRO A CG 1 ATOM 1070 C CD . PRO A 1 142 ? 17.068 60.554 40.093 1.00 39.12 ? 208 PRO A CD 1 ATOM 1071 N N . ILE A 1 143 ? 17.558 59.731 44.706 1.00 34.37 ? 209 ILE A N 1 ATOM 1072 C CA . ILE A 1 143 ? 16.940 59.861 46.032 1.00 33.50 ? 209 ILE A CA 1 ATOM 1073 C C . ILE A 1 143 ? 16.370 61.267 46.301 1.00 37.14 ? 209 ILE A C 1 ATOM 1074 O O . ILE A 1 143 ? 15.297 61.344 46.893 1.00 38.10 ? 209 ILE A O 1 ATOM 1075 C CB . ILE A 1 143 ? 17.890 59.384 47.178 1.00 35.62 ? 209 ILE A CB 1 ATOM 1076 C CG1 . ILE A 1 143 ? 17.090 58.970 48.435 1.00 35.47 ? 209 ILE A CG1 1 ATOM 1077 C CG2 . ILE A 1 143 ? 18.993 60.404 47.482 1.00 35.95 ? 209 ILE A CG2 1 ATOM 1078 C CD1 . ILE A 1 143 ? 17.843 58.160 49.522 1.00 33.72 ? 209 ILE A CD1 1 ATOM 1079 N N . PHE A 1 144 ? 17.062 62.358 45.885 1.00 32.96 ? 210 PHE A N 1 ATOM 1080 C CA . PHE A 1 144 ? 16.568 63.713 46.166 1.00 32.47 ? 210 PHE A CA 1 ATOM 1081 C C . PHE A 1 144 ? 15.269 64.020 45.412 1.00 38.18 ? 210 PHE A C 1 ATOM 1082 O O . PHE A 1 144 ? 14.358 64.613 45.998 1.00 39.05 ? 210 PHE A O 1 ATOM 1083 C CB . PHE A 1 144 ? 17.637 64.810 45.977 1.00 33.21 ? 210 PHE A CB 1 ATOM 1084 C CG . PHE A 1 144 ? 17.296 66.098 46.710 1.00 33.94 ? 210 PHE A CG 1 ATOM 1085 C CD1 . PHE A 1 144 ? 17.328 66.163 48.104 1.00 35.62 ? 210 PHE A CD1 1 ATOM 1086 C CD2 . PHE A 1 144 ? 16.930 67.240 46.009 1.00 36.07 ? 210 PHE A CD2 1 ATOM 1087 C CE1 . PHE A 1 144 ? 16.993 67.352 48.776 1.00 36.26 ? 210 PHE A CE1 1 ATOM 1088 C CE2 . PHE A 1 144 ? 16.608 68.431 46.683 1.00 38.30 ? 210 PHE A CE2 1 ATOM 1089 C CZ . PHE A 1 144 ? 16.638 68.480 48.055 1.00 35.89 ? 210 PHE A CZ 1 ATOM 1090 N N . ASP A 1 145 ? 15.157 63.554 44.146 1.00 34.86 ? 211 ASP A N 1 ATOM 1091 C CA . ASP A 1 145 ? 13.944 63.675 43.330 1.00 33.90 ? 211 ASP A CA 1 ATOM 1092 C C . ASP A 1 145 ? 12.773 63.002 44.038 1.00 41.65 ? 211 ASP A C 1 ATOM 1093 O O . ASP A 1 145 ? 11.687 63.582 44.121 1.00 44.27 ? 211 ASP A O 1 ATOM 1094 C CB . ASP A 1 145 ? 14.145 63.062 41.948 1.00 35.07 ? 211 ASP A CB 1 ATOM 1095 C CG . ASP A 1 145 ? 15.174 63.774 41.099 1.00 51.06 ? 211 ASP A CG 1 ATOM 1096 O OD1 . ASP A 1 145 ? 16.323 63.915 41.554 1.00 55.73 ? 211 ASP A OD1 1 ATOM 1097 O OD2 . ASP A 1 145 ? 14.855 64.120 39.951 1.00 59.82 ? 211 ASP A OD2 1 ATOM 1098 N N . ASN A 1 146 ? 13.004 61.815 44.599 1.00 38.92 ? 212 ASN A N 1 ATOM 1099 C CA . ASN A 1 146 ? 11.981 61.058 45.316 1.00 39.25 ? 212 ASN A CA 1 ATOM 1100 C C . ASN A 1 146 ? 11.563 61.736 46.593 1.00 43.80 ? 212 ASN A C 1 ATOM 1101 O O . ASN A 1 146 ? 10.379 61.698 46.928 1.00 44.86 ? 212 ASN A O 1 ATOM 1102 C CB . ASN A 1 146 ? 12.420 59.614 45.552 1.00 38.14 ? 212 ASN A CB 1 ATOM 1103 C CG . ASN A 1 146 ? 12.386 58.747 44.323 1.00 44.20 ? 212 ASN A CG 1 ATOM 1104 O OD1 . ASN A 1 146 ? 11.519 58.872 43.471 1.00 36.93 ? 212 ASN A OD1 1 ATOM 1105 N ND2 . ASN A 1 146 ? 13.299 57.807 44.223 1.00 36.40 ? 212 ASN A ND2 1 ATOM 1106 N N . ILE A 1 147 ? 12.514 62.403 47.278 1.00 39.82 ? 213 ILE A N 1 ATOM 1107 C CA . ILE A 1 147 ? 12.220 63.152 48.504 1.00 39.67 ? 213 ILE A CA 1 ATOM 1108 C C . ILE A 1 147 ? 11.365 64.396 48.133 1.00 46.31 ? 213 ILE A C 1 ATOM 1109 O O . ILE A 1 147 ? 10.364 64.667 48.796 1.00 47.29 ? 213 ILE A O 1 ATOM 1110 C CB . ILE A 1 147 ? 13.497 63.464 49.329 1.00 41.90 ? 213 ILE A CB 1 ATOM 1111 C CG1 . ILE A 1 147 ? 14.114 62.163 49.912 1.00 41.71 ? 213 ILE A CG1 1 ATOM 1112 C CG2 . ILE A 1 147 ? 13.195 64.465 50.444 1.00 43.09 ? 213 ILE A CG2 1 ATOM 1113 C CD1 . ILE A 1 147 ? 15.564 62.289 50.466 1.00 38.93 ? 213 ILE A CD1 1 ATOM 1114 N N . ILE A 1 148 ? 11.721 65.084 47.024 1.00 42.34 ? 214 ILE A N 1 ATOM 1115 C CA . ILE A 1 148 ? 10.968 66.219 46.492 1.00 42.53 ? 214 ILE A CA 1 ATOM 1116 C C . ILE A 1 148 ? 9.490 65.819 46.218 1.00 45.84 ? 214 ILE A C 1 ATOM 1117 O O . ILE A 1 148 ? 8.585 66.553 46.619 1.00 47.49 ? 214 ILE A O 1 ATOM 1118 C CB . ILE A 1 148 ? 11.672 66.836 45.247 1.00 45.54 ? 214 ILE A CB 1 ATOM 1119 C CG1 . ILE A 1 148 ? 12.934 67.656 45.653 1.00 45.52 ? 214 ILE A CG1 1 ATOM 1120 C CG2 . ILE A 1 148 ? 10.671 67.680 44.386 1.00 45.31 ? 214 ILE A CG2 1 ATOM 1121 C CD1 . ILE A 1 148 ? 13.740 68.393 44.396 1.00 49.27 ? 214 ILE A CD1 1 ATOM 1122 N N . SER A 1 149 ? 9.264 64.642 45.595 1.00 39.70 ? 215 SER A N 1 ATOM 1123 C CA . SER A 1 149 ? 7.934 64.097 45.305 1.00 39.54 ? 215 SER A CA 1 ATOM 1124 C C . SER A 1 149 ? 7.046 63.993 46.558 1.00 44.42 ? 215 SER A C 1 ATOM 1125 O O . SER A 1 149 ? 5.828 64.068 46.443 1.00 45.42 ? 215 SER A O 1 ATOM 1126 C CB . SER A 1 149 ? 8.039 62.724 44.641 1.00 42.01 ? 215 SER A CB 1 ATOM 1127 O OG . SER A 1 149 ? 8.609 62.844 43.351 1.00 52.45 ? 215 SER A OG 1 ATOM 1128 N N . GLN A 1 150 ? 7.642 63.819 47.746 1.00 40.57 ? 216 GLN A N 1 ATOM 1129 C CA . GLN A 1 150 ? 6.873 63.739 49.000 1.00 39.91 ? 216 GLN A CA 1 ATOM 1130 C C . GLN A 1 150 ? 6.286 65.105 49.395 1.00 44.19 ? 216 GLN A C 1 ATOM 1131 O O . GLN A 1 150 ? 5.387 65.146 50.232 1.00 44.15 ? 216 GLN A O 1 ATOM 1132 C CB . GLN A 1 150 ? 7.717 63.187 50.163 1.00 40.35 ? 216 GLN A CB 1 ATOM 1133 C CG . GLN A 1 150 ? 8.420 61.872 49.847 1.00 53.81 ? 216 GLN A CG 1 ATOM 1134 C CD . GLN A 1 150 ? 9.093 61.247 51.042 1.00 63.10 ? 216 GLN A CD 1 ATOM 1135 O OE1 . GLN A 1 150 ? 9.425 61.904 52.030 1.00 58.01 ? 216 GLN A OE1 1 ATOM 1136 N NE2 . GLN A 1 150 ? 9.325 59.952 50.962 1.00 59.22 ? 216 GLN A NE2 1 ATOM 1137 N N . GLY A 1 151 ? 6.830 66.188 48.828 1.00 40.54 ? 217 GLY A N 1 ATOM 1138 C CA . GLY A 1 151 ? 6.432 67.558 49.115 1.00 41.22 ? 217 GLY A CA 1 ATOM 1139 C C . GLY A 1 151 ? 6.484 67.919 50.587 1.00 48.95 ? 217 GLY A C 1 ATOM 1140 O O . GLY A 1 151 ? 5.555 68.558 51.092 1.00 50.22 ? 217 GLY A O 1 ATOM 1141 N N . VAL A 1 152 ? 7.555 67.484 51.294 1.00 46.22 ? 218 VAL A N 1 ATOM 1142 C CA . VAL A 1 152 ? 7.722 67.724 52.735 1.00 45.64 ? 218 VAL A CA 1 ATOM 1143 C C . VAL A 1 152 ? 8.797 68.793 53.034 1.00 48.38 ? 218 VAL A C 1 ATOM 1144 O O . VAL A 1 152 ? 8.718 69.450 54.074 1.00 48.53 ? 218 VAL A O 1 ATOM 1145 C CB . VAL A 1 152 ? 7.938 66.420 53.567 1.00 49.31 ? 218 VAL A CB 1 ATOM 1146 C CG1 . VAL A 1 152 ? 6.744 65.489 53.437 1.00 48.89 ? 218 VAL A CG1 1 ATOM 1147 C CG2 . VAL A 1 152 ? 9.229 65.694 53.195 1.00 49.17 ? 218 VAL A CG2 1 ATOM 1148 N N . LEU A 1 153 ? 9.750 68.998 52.112 1.00 43.39 ? 219 LEU A N 1 ATOM 1149 C CA . LEU A 1 153 ? 10.850 69.961 52.276 1.00 42.35 ? 219 LEU A CA 1 ATOM 1150 C C . LEU A 1 153 ? 10.421 71.435 52.180 1.00 47.09 ? 219 LEU A C 1 ATOM 1151 O O . LEU A 1 153 ? 9.625 71.774 51.308 1.00 47.21 ? 219 LEU A O 1 ATOM 1152 C CB . LEU A 1 153 ? 12.001 69.659 51.275 1.00 41.81 ? 219 LEU A CB 1 ATOM 1153 C CG . LEU A 1 153 ? 12.759 68.303 51.438 1.00 45.40 ? 219 LEU A CG 1 ATOM 1154 C CD1 . LEU A 1 153 ? 13.835 68.172 50.421 1.00 45.54 ? 219 LEU A CD1 1 ATOM 1155 C CD2 . LEU A 1 153 ? 13.375 68.139 52.830 1.00 45.07 ? 219 LEU A CD2 1 ATOM 1156 N N . LYS A 1 154 ? 10.983 72.322 53.044 1.00 43.34 ? 220 LYS A N 1 ATOM 1157 C CA . LYS A 1 154 ? 10.688 73.763 52.983 1.00 42.21 ? 220 LYS A CA 1 ATOM 1158 C C . LYS A 1 154 ? 11.162 74.334 51.643 1.00 47.92 ? 220 LYS A C 1 ATOM 1159 O O . LYS A 1 154 ? 10.449 75.131 51.036 1.00 49.38 ? 220 LYS A O 1 ATOM 1160 C CB . LYS A 1 154 ? 11.290 74.534 54.179 1.00 42.63 ? 220 LYS A CB 1 ATOM 1161 N N . GLU A 1 155 ? 12.338 73.891 51.163 1.00 44.52 ? 221 GLU A N 1 ATOM 1162 C CA . GLU A 1 155 ? 12.905 74.310 49.879 1.00 44.42 ? 221 GLU A CA 1 ATOM 1163 C C . GLU A 1 155 ? 13.513 73.121 49.110 1.00 47.95 ? 221 GLU A C 1 ATOM 1164 O O . GLU A 1 155 ? 13.958 72.134 49.690 1.00 46.29 ? 221 GLU A O 1 ATOM 1165 C CB . GLU A 1 155 ? 13.973 75.400 50.046 1.00 45.62 ? 221 GLU A CB 1 ATOM 1166 C CG . GLU A 1 155 ? 13.503 76.761 50.485 1.00 55.87 ? 221 GLU A CG 1 ATOM 1167 C CD . GLU A 1 155 ? 14.697 77.482 51.064 1.00 85.96 ? 221 GLU A CD 1 ATOM 1168 O OE1 . GLU A 1 155 ? 15.463 78.083 50.274 1.00 80.11 ? 221 GLU A OE1 1 ATOM 1169 O OE2 . GLU A 1 155 ? 14.924 77.369 52.291 1.00 86.67 ? 221 GLU A OE2 1 ATOM 1170 N N . ASP A 1 156 ? 13.557 73.257 47.791 1.00 44.92 ? 222 ASP A N 1 ATOM 1171 C CA . ASP A 1 156 ? 14.083 72.294 46.822 1.00 44.56 ? 222 ASP A CA 1 ATOM 1172 C C . ASP A 1 156 ? 15.607 72.488 46.763 1.00 44.33 ? 222 ASP A C 1 ATOM 1173 O O . ASP A 1 156 ? 16.173 72.725 45.694 1.00 43.74 ? 222 ASP A O 1 ATOM 1174 C CB . ASP A 1 156 ? 13.484 72.650 45.448 1.00 47.87 ? 222 ASP A CB 1 ATOM 1175 C CG . ASP A 1 156 ? 12.554 71.656 44.819 1.00 66.02 ? 222 ASP A CG 1 ATOM 1176 O OD1 . ASP A 1 156 ? 11.725 71.069 45.567 1.00 64.87 ? 222 ASP A OD1 1 ATOM 1177 O OD2 . ASP A 1 156 ? 12.570 71.542 43.556 1.00 77.76 ? 222 ASP A OD2 1 ATOM 1178 N N . VAL A 1 157 ? 16.262 72.477 47.929 1.00 38.36 ? 223 VAL A N 1 ATOM 1179 C CA . VAL A 1 157 ? 17.705 72.699 48.068 1.00 36.18 ? 223 VAL A CA 1 ATOM 1180 C C . VAL A 1 157 ? 18.314 71.709 49.081 1.00 36.32 ? 223 VAL A C 1 ATOM 1181 O O . VAL A 1 157 ? 17.603 71.119 49.889 1.00 35.82 ? 223 VAL A O 1 ATOM 1182 C CB . VAL A 1 157 ? 18.042 74.206 48.438 1.00 39.31 ? 223 VAL A CB 1 ATOM 1183 C CG1 . VAL A 1 157 ? 17.183 75.211 47.661 1.00 38.49 ? 223 VAL A CG1 1 ATOM 1184 C CG2 . VAL A 1 157 ? 17.927 74.471 49.932 1.00 38.71 ? 223 VAL A CG2 1 ATOM 1185 N N . PHE A 1 158 ? 19.629 71.565 49.062 1.00 30.89 ? 224 PHE A N 1 ATOM 1186 C CA . PHE A 1 158 ? 20.377 70.786 50.045 1.00 28.84 ? 224 PHE A CA 1 ATOM 1187 C C . PHE A 1 158 ? 21.723 71.480 50.206 1.00 32.92 ? 224 PHE A C 1 ATOM 1188 O O . PHE A 1 158 ? 22.204 72.083 49.250 1.00 31.53 ? 224 PHE A O 1 ATOM 1189 C CB . PHE A 1 158 ? 20.473 69.279 49.717 1.00 29.06 ? 224 PHE A CB 1 ATOM 1190 C CG . PHE A 1 158 ? 21.073 68.922 48.379 1.00 28.85 ? 224 PHE A CG 1 ATOM 1191 C CD1 . PHE A 1 158 ? 22.444 68.770 48.230 1.00 29.54 ? 224 PHE A CD1 1 ATOM 1192 C CD2 . PHE A 1 158 ? 20.259 68.701 47.270 1.00 29.52 ? 224 PHE A CD2 1 ATOM 1193 C CE1 . PHE A 1 158 ? 22.989 68.442 46.992 1.00 30.26 ? 224 PHE A CE1 1 ATOM 1194 C CE2 . PHE A 1 158 ? 20.805 68.359 46.043 1.00 30.91 ? 224 PHE A CE2 1 ATOM 1195 C CZ . PHE A 1 158 ? 22.164 68.227 45.911 1.00 29.13 ? 224 PHE A CZ 1 ATOM 1196 N N . SER A 1 159 ? 22.316 71.424 51.407 1.00 30.20 ? 225 SER A N 1 ATOM 1197 C CA . SER A 1 159 ? 23.540 72.143 51.726 1.00 28.19 ? 225 SER A CA 1 ATOM 1198 C C . SER A 1 159 ? 24.541 71.276 52.431 1.00 32.19 ? 225 SER A C 1 ATOM 1199 O O . SER A 1 159 ? 24.166 70.402 53.223 1.00 30.57 ? 225 SER A O 1 ATOM 1200 C CB . SER A 1 159 ? 23.225 73.326 52.631 1.00 29.21 ? 225 SER A CB 1 ATOM 1201 O OG . SER A 1 159 ? 22.185 74.096 52.075 1.00 46.05 ? 225 SER A OG 1 ATOM 1202 N N . PHE A 1 160 ? 25.824 71.637 52.258 1.00 28.89 ? 226 PHE A N 1 ATOM 1203 C CA . PHE A 1 160 ? 26.953 70.923 52.808 1.00 27.96 ? 226 PHE A CA 1 ATOM 1204 C C . PHE A 1 160 ? 27.840 71.806 53.604 1.00 32.74 ? 226 PHE A C 1 ATOM 1205 O O . PHE A 1 160 ? 28.222 72.898 53.161 1.00 32.18 ? 226 PHE A O 1 ATOM 1206 C CB . PHE A 1 160 ? 27.800 70.299 51.687 1.00 28.88 ? 226 PHE A CB 1 ATOM 1207 C CG . PHE A 1 160 ? 27.258 69.001 51.141 1.00 29.41 ? 226 PHE A CG 1 ATOM 1208 C CD1 . PHE A 1 160 ? 26.159 68.991 50.287 1.00 32.12 ? 226 PHE A CD1 1 ATOM 1209 C CD2 . PHE A 1 160 ? 27.872 67.787 51.447 1.00 28.15 ? 226 PHE A CD2 1 ATOM 1210 C CE1 . PHE A 1 160 ? 25.668 67.782 49.765 1.00 32.40 ? 226 PHE A CE1 1 ATOM 1211 C CE2 . PHE A 1 160 ? 27.396 66.590 50.910 1.00 30.53 ? 226 PHE A CE2 1 ATOM 1212 C CZ . PHE A 1 160 ? 26.317 66.596 50.050 1.00 30.34 ? 226 PHE A CZ 1 ATOM 1213 N N . TYR A 1 161 ? 28.221 71.283 54.766 1.00 28.58 ? 227 TYR A N 1 ATOM 1214 C CA . TYR A 1 161 ? 29.196 71.878 55.643 1.00 28.49 ? 227 TYR A CA 1 ATOM 1215 C C . TYR A 1 161 ? 30.231 70.787 55.852 1.00 33.09 ? 227 TYR A C 1 ATOM 1216 O O . TYR A 1 161 ? 29.859 69.675 56.227 1.00 33.99 ? 227 TYR A O 1 ATOM 1217 C CB . TYR A 1 161 ? 28.572 72.296 56.988 1.00 29.11 ? 227 TYR A CB 1 ATOM 1218 C CG . TYR A 1 161 ? 29.613 72.558 58.055 1.00 27.79 ? 227 TYR A CG 1 ATOM 1219 C CD1 . TYR A 1 161 ? 30.537 73.591 57.915 1.00 28.96 ? 227 TYR A CD1 1 ATOM 1220 C CD2 . TYR A 1 161 ? 29.698 71.752 59.189 1.00 28.11 ? 227 TYR A CD2 1 ATOM 1221 C CE1 . TYR A 1 161 ? 31.535 73.805 58.864 1.00 27.90 ? 227 TYR A CE1 1 ATOM 1222 C CE2 . TYR A 1 161 ? 30.678 71.976 60.167 1.00 28.78 ? 227 TYR A CE2 1 ATOM 1223 C CZ . TYR A 1 161 ? 31.590 73.011 59.998 1.00 35.65 ? 227 TYR A CZ 1 ATOM 1224 O OH . TYR A 1 161 ? 32.573 73.256 60.919 1.00 39.64 ? 227 TYR A OH 1 ATOM 1225 N N . TYR A 1 162 ? 31.506 71.081 55.563 1.00 28.73 ? 228 TYR A N 1 ATOM 1226 C CA . TYR A 1 162 ? 32.615 70.147 55.777 1.00 28.48 ? 228 TYR A CA 1 ATOM 1227 C C . TYR A 1 162 ? 33.586 70.818 56.753 1.00 33.56 ? 228 TYR A C 1 ATOM 1228 O O . TYR A 1 162 ? 34.088 71.905 56.480 1.00 32.14 ? 228 TYR A O 1 ATOM 1229 C CB . TYR A 1 162 ? 33.330 69.812 54.442 1.00 29.51 ? 228 TYR A CB 1 ATOM 1230 C CG . TYR A 1 162 ? 32.690 68.740 53.580 1.00 29.60 ? 228 TYR A CG 1 ATOM 1231 C CD1 . TYR A 1 162 ? 31.576 68.027 54.024 1.00 30.79 ? 228 TYR A CD1 1 ATOM 1232 C CD2 . TYR A 1 162 ? 33.221 68.411 52.341 1.00 29.69 ? 228 TYR A CD2 1 ATOM 1233 C CE1 . TYR A 1 162 ? 30.989 67.039 53.232 1.00 29.24 ? 228 TYR A CE1 1 ATOM 1234 C CE2 . TYR A 1 162 ? 32.667 67.400 51.560 1.00 30.23 ? 228 TYR A CE2 1 ATOM 1235 C CZ . TYR A 1 162 ? 31.557 66.706 52.013 1.00 31.94 ? 228 TYR A CZ 1 ATOM 1236 O OH . TYR A 1 162 ? 31.015 65.704 51.230 1.00 26.21 ? 228 TYR A OH 1 ATOM 1237 N N . ASN A 1 163 ? 33.809 70.213 57.912 1.00 33.50 ? 229 ASN A N 1 ATOM 1238 C CA . ASN A 1 163 ? 34.737 70.768 58.906 1.00 33.05 ? 229 ASN A CA 1 ATOM 1239 C C . ASN A 1 163 ? 36.194 70.371 58.612 1.00 38.94 ? 229 ASN A C 1 ATOM 1240 O O . ASN A 1 163 ? 36.454 69.483 57.797 1.00 37.32 ? 229 ASN A O 1 ATOM 1241 C CB . ASN A 1 163 ? 34.310 70.291 60.311 1.00 30.90 ? 229 ASN A CB 1 ATOM 1242 C CG . ASN A 1 163 ? 34.811 71.110 61.483 1.00 44.37 ? 229 ASN A CG 1 ATOM 1243 O OD1 . ASN A 1 163 ? 35.625 72.034 61.363 1.00 35.39 ? 229 ASN A OD1 1 ATOM 1244 N ND2 . ASN A 1 163 ? 34.356 70.771 62.661 1.00 36.94 ? 229 ASN A ND2 1 ATOM 1245 N N . ARG A 1 164 ? 37.129 71.053 59.277 1.00 41.46 ? 230 ARG A N 1 ATOM 1246 C CA . ARG A 1 164 ? 38.575 70.800 59.297 1.00 44.66 ? 230 ARG A CA 1 ATOM 1247 C C . ARG A 1 164 ? 38.805 69.674 60.307 1.00 56.15 ? 230 ARG A C 1 ATOM 1248 O O . ARG A 1 164 ? 38.163 69.656 61.352 1.00 54.56 ? 230 ARG A O 1 ATOM 1249 C CB . ARG A 1 164 ? 39.322 72.074 59.729 1.00 48.25 ? 230 ARG A CB 1 ATOM 1250 C CG . ARG A 1 164 ? 39.481 73.098 58.602 1.00 63.63 ? 230 ARG A CG 1 ATOM 1251 C CD . ARG A 1 164 ? 38.509 74.266 58.679 1.00 74.49 ? 230 ARG A CD 1 ATOM 1252 N NE . ARG A 1 164 ? 38.751 75.206 57.579 1.00 82.12 ? 230 ARG A NE 1 ATOM 1253 C CZ . ARG A 1 164 ? 38.186 76.402 57.456 1.00 100.78 ? 230 ARG A CZ 1 ATOM 1254 N NH1 . ARG A 1 164 ? 37.318 76.833 58.366 1.00 97.67 ? 230 ARG A NH1 1 ATOM 1255 N NH2 . ARG A 1 164 ? 38.480 77.175 56.419 1.00 87.59 ? 230 ARG A NH2 1 ATOM 1256 N N . ASP A 1 165 ? 39.677 68.704 59.978 1.00 61.71 ? 231 ASP A N 1 ATOM 1257 C CA . ASP A 1 165 ? 39.879 67.516 60.817 1.00 64.73 ? 231 ASP A CA 1 ATOM 1258 C C . ASP A 1 165 ? 40.499 67.783 62.164 1.00 76.67 ? 231 ASP A C 1 ATOM 1259 O O . ASP A 1 165 ? 41.726 67.890 62.311 1.00 77.90 ? 231 ASP A O 1 ATOM 1260 C CB . ASP A 1 165 ? 40.652 66.388 60.109 1.00 66.11 ? 231 ASP A CB 1 ATOM 1261 C CG . ASP A 1 165 ? 40.641 65.064 60.860 1.00 68.47 ? 231 ASP A CG 1 ATOM 1262 O OD1 . ASP A 1 165 ? 39.594 64.735 61.495 1.00 68.48 ? 231 ASP A OD1 1 ATOM 1263 O OD2 . ASP A 1 165 ? 41.658 64.351 60.804 1.00 70.80 ? 231 ASP A OD2 1 ATOM 1264 N N . SER A 1 166 ? 39.628 67.786 63.160 1.00 76.94 ? 232 SER A N 1 ATOM 1265 C CA . SER A 1 166 ? 39.999 67.904 64.549 1.00 78.57 ? 232 SER A CA 1 ATOM 1266 C C . SER A 1 166 ? 40.130 66.467 65.096 1.00 87.00 ? 232 SER A C 1 ATOM 1267 O O . SER A 1 166 ? 39.480 65.538 64.597 1.00 86.78 ? 232 SER A O 1 ATOM 1268 C CB . SER A 1 166 ? 38.936 68.703 65.300 1.00 81.96 ? 232 SER A CB 1 ATOM 1269 O OG . SER A 1 166 ? 38.926 68.469 66.698 1.00 90.14 ? 232 SER A OG 1 ATOM 1270 N N . GLU A 1 167 ? 41.013 66.285 66.082 1.00 86.69 ? 233 GLU A N 1 ATOM 1271 C CA . GLU A 1 167 ? 41.206 65.006 66.764 1.00 87.82 ? 233 GLU A CA 1 ATOM 1272 C C . GLU A 1 167 ? 40.209 64.899 67.945 1.00 93.15 ? 233 GLU A C 1 ATOM 1273 O O . GLU A 1 167 ? 40.003 63.811 68.495 1.00 93.17 ? 233 GLU A O 1 ATOM 1274 C CB . GLU A 1 167 ? 42.678 64.801 67.198 1.00 89.61 ? 233 GLU A CB 1 ATOM 1275 C CG . GLU A 1 167 ? 43.338 65.974 67.911 1.00 102.64 ? 233 GLU A CG 1 ATOM 1276 C CD . GLU A 1 167 ? 44.849 66.003 67.768 1.00 127.27 ? 233 GLU A CD 1 ATOM 1277 O OE1 . GLU A 1 167 ? 45.544 65.350 68.580 1.00 117.31 ? 233 GLU A OE1 1 ATOM 1278 O OE2 . GLU A 1 167 ? 45.339 66.682 66.838 1.00 124.85 ? 233 GLU A OE2 1 ATOM 1279 N N . ASN A 1 168 ? 39.566 66.040 68.300 1.00 89.55 ? 234 ASN A N 1 ATOM 1280 C CA . ASN A 1 168 ? 38.565 66.112 69.356 1.00 88.92 ? 234 ASN A CA 1 ATOM 1281 C C . ASN A 1 168 ? 37.304 65.439 68.875 1.00 91.52 ? 234 ASN A C 1 ATOM 1282 O O . ASN A 1 168 ? 36.904 65.601 67.717 1.00 90.93 ? 234 ASN A O 1 ATOM 1283 C CB . ASN A 1 168 ? 38.283 67.561 69.786 1.00 89.47 ? 234 ASN A CB 1 ATOM 1284 C CG . ASN A 1 168 ? 39.444 68.252 70.479 1.00 111.81 ? 234 ASN A CG 1 ATOM 1285 O OD1 . ASN A 1 168 ? 40.225 67.646 71.231 1.00 102.41 ? 234 ASN A OD1 1 ATOM 1286 N ND2 . ASN A 1 168 ? 39.560 69.557 70.271 1.00 104.74 ? 234 ASN A ND2 1 ATOM 1287 N N . SER A 1 169 ? 36.722 64.630 69.754 1.00 87.05 ? 235 SER A N 1 ATOM 1288 C CA . SER A 1 169 ? 35.504 63.876 69.499 1.00 86.00 ? 235 SER A CA 1 ATOM 1289 C C . SER A 1 169 ? 34.282 64.806 69.493 1.00 87.15 ? 235 SER A C 1 ATOM 1290 O O . SER A 1 169 ? 33.322 64.543 68.760 1.00 87.17 ? 235 SER A O 1 ATOM 1291 C CB . SER A 1 169 ? 35.353 62.769 70.537 1.00 89.36 ? 235 SER A CB 1 ATOM 1292 O OG . SER A 1 169 ? 36.494 61.926 70.514 1.00 96.80 ? 235 SER A OG 1 ATOM 1293 N N . GLN A 1 170 ? 34.349 65.917 70.271 1.00 80.51 ? 236 GLN A N 1 ATOM 1294 C CA . GLN A 1 170 ? 33.295 66.940 70.384 1.00 78.76 ? 236 GLN A CA 1 ATOM 1295 C C . GLN A 1 170 ? 33.085 67.720 69.060 1.00 77.42 ? 236 GLN A C 1 ATOM 1296 O O . GLN A 1 170 ? 32.081 68.427 68.899 1.00 77.26 ? 236 GLN A O 1 ATOM 1297 C CB . GLN A 1 170 ? 33.597 67.898 71.558 1.00 80.14 ? 236 GLN A CB 1 ATOM 1298 N N . SER A 1 171 ? 34.037 67.566 68.117 1.00 68.66 ? 237 SER A N 1 ATOM 1299 C CA . SER A 1 171 ? 34.030 68.182 66.796 1.00 65.56 ? 237 SER A CA 1 ATOM 1300 C C . SER A 1 171 ? 33.090 67.450 65.836 1.00 63.65 ? 237 SER A C 1 ATOM 1301 O O . SER A 1 171 ? 33.178 66.229 65.659 1.00 64.97 ? 237 SER A O 1 ATOM 1302 C CB . SER A 1 171 ? 35.442 68.212 66.221 1.00 67.78 ? 237 SER A CB 1 ATOM 1303 O OG . SER A 1 171 ? 35.521 68.981 65.034 1.00 76.55 ? 237 SER A OG 1 ATOM 1304 N N . LEU A 1 172 ? 32.196 68.216 65.216 1.00 53.29 ? 238 LEU A N 1 ATOM 1305 C CA . LEU A 1 172 ? 31.252 67.767 64.205 1.00 49.56 ? 238 LEU A CA 1 ATOM 1306 C C . LEU A 1 172 ? 32.050 67.652 62.882 1.00 44.96 ? 238 LEU A C 1 ATOM 1307 O O . LEU A 1 172 ? 32.579 68.667 62.422 1.00 42.70 ? 238 LEU A O 1 ATOM 1308 C CB . LEU A 1 172 ? 30.153 68.860 64.086 1.00 49.56 ? 238 LEU A CB 1 ATOM 1309 C CG . LEU A 1 172 ? 29.172 68.751 62.928 1.00 54.23 ? 238 LEU A CG 1 ATOM 1310 C CD1 . LEU A 1 172 ? 28.074 67.807 63.258 1.00 55.16 ? 238 LEU A CD1 1 ATOM 1311 C CD2 . LEU A 1 172 ? 28.590 70.088 62.575 1.00 54.03 ? 238 LEU A CD2 1 ATOM 1312 N N . GLY A 1 173 ? 32.115 66.454 62.288 1.00 37.34 ? 239 GLY A N 1 ATOM 1313 C CA . GLY A 1 173 ? 32.835 66.232 61.029 1.00 36.08 ? 239 GLY A CA 1 ATOM 1314 C C . GLY A 1 173 ? 32.299 67.022 59.838 1.00 37.77 ? 239 GLY A C 1 ATOM 1315 O O . GLY A 1 173 ? 33.062 67.480 58.979 1.00 37.24 ? 239 GLY A O 1 ATOM 1316 N N . GLY A 1 174 ? 30.981 67.185 59.809 1.00 31.16 ? 240 GLY A N 1 ATOM 1317 C CA . GLY A 1 174 ? 30.252 67.890 58.773 1.00 29.46 ? 240 GLY A CA 1 ATOM 1318 C C . GLY A 1 174 ? 28.759 67.701 58.953 1.00 33.12 ? 240 GLY A C 1 ATOM 1319 O O . GLY A 1 174 ? 28.304 67.069 59.918 1.00 32.31 ? 240 GLY A O 1 ATOM 1320 N N . GLN A 1 175 ? 27.987 68.248 58.024 1.00 28.93 ? 241 GLN A N 1 ATOM 1321 C CA . GLN A 1 175 ? 26.535 68.208 58.071 1.00 28.29 ? 241 GLN A CA 1 ATOM 1322 C C . GLN A 1 175 ? 25.941 68.536 56.705 1.00 33.80 ? 241 GLN A C 1 ATOM 1323 O O . GLN A 1 175 ? 26.377 69.493 56.053 1.00 35.07 ? 241 GLN A O 1 ATOM 1324 C CB . GLN A 1 175 ? 26.043 69.247 59.111 1.00 29.78 ? 241 GLN A CB 1 ATOM 1325 C CG . GLN A 1 175 ? 24.546 69.250 59.410 1.00 37.49 ? 241 GLN A CG 1 ATOM 1326 C CD . GLN A 1 175 ? 24.106 70.605 59.925 1.00 49.36 ? 241 GLN A CD 1 ATOM 1327 O OE1 . GLN A 1 175 ? 24.367 71.668 59.330 1.00 38.31 ? 241 GLN A OE1 1 ATOM 1328 N NE2 . GLN A 1 175 ? 23.424 70.595 61.047 1.00 44.17 ? 241 GLN A NE2 1 ATOM 1329 N N . ILE A 1 176 ? 24.978 67.705 56.265 1.00 30.48 ? 242 ILE A N 1 ATOM 1330 C CA . ILE A 1 176 ? 24.143 67.889 55.091 1.00 30.82 ? 242 ILE A CA 1 ATOM 1331 C C . ILE A 1 176 ? 22.717 68.265 55.584 1.00 36.65 ? 242 ILE A C 1 ATOM 1332 O O . ILE A 1 176 ? 22.138 67.565 56.429 1.00 34.98 ? 242 ILE A O 1 ATOM 1333 C CB . ILE A 1 176 ? 24.136 66.741 54.013 1.00 33.98 ? 242 ILE A CB 1 ATOM 1334 C CG1 . ILE A 1 176 ? 23.039 67.012 52.936 1.00 33.97 ? 242 ILE A CG1 1 ATOM 1335 C CG2 . ILE A 1 176 ? 23.964 65.345 54.608 1.00 33.43 ? 242 ILE A CG2 1 ATOM 1336 C CD1 . ILE A 1 176 ? 23.033 66.101 51.707 1.00 43.55 ? 242 ILE A CD1 1 ATOM 1337 N N . VAL A 1 177 ? 22.190 69.401 55.084 1.00 33.74 ? 243 VAL A N 1 ATOM 1338 C CA . VAL A 1 177 ? 20.827 69.855 55.369 1.00 32.58 ? 243 VAL A CA 1 ATOM 1339 C C . VAL A 1 177 ? 20.024 69.637 54.094 1.00 34.95 ? 243 VAL A C 1 ATOM 1340 O O . VAL A 1 177 ? 20.423 70.117 53.039 1.00 32.48 ? 243 VAL A O 1 ATOM 1341 C CB . VAL A 1 177 ? 20.749 71.340 55.828 1.00 35.83 ? 243 VAL A CB 1 ATOM 1342 C CG1 . VAL A 1 177 ? 19.306 71.744 56.110 1.00 34.67 ? 243 VAL A CG1 1 ATOM 1343 C CG2 . VAL A 1 177 ? 21.618 71.584 57.055 1.00 35.64 ? 243 VAL A CG2 1 ATOM 1344 N N . LEU A 1 178 ? 18.942 68.858 54.184 1.00 33.86 ? 244 LEU A N 1 ATOM 1345 C CA . LEU A 1 178 ? 18.004 68.617 53.090 1.00 33.90 ? 244 LEU A CA 1 ATOM 1346 C C . LEU A 1 178 ? 16.866 69.591 53.298 1.00 38.82 ? 244 LEU A C 1 ATOM 1347 O O . LEU A 1 178 ? 16.262 69.625 54.369 1.00 39.38 ? 244 LEU A O 1 ATOM 1348 C CB . LEU A 1 178 ? 17.446 67.183 53.109 1.00 33.75 ? 244 LEU A CB 1 ATOM 1349 C CG . LEU A 1 178 ? 18.444 66.022 53.090 1.00 38.90 ? 244 LEU A CG 1 ATOM 1350 C CD1 . LEU A 1 178 ? 17.728 64.700 53.224 1.00 39.21 ? 244 LEU A CD1 1 ATOM 1351 C CD2 . LEU A 1 178 ? 19.275 66.011 51.813 1.00 41.02 ? 244 LEU A CD2 1 ATOM 1352 N N . GLY A 1 179 ? 16.600 70.404 52.299 1.00 36.72 ? 245 GLY A N 1 ATOM 1353 C CA . GLY A 1 179 ? 15.497 71.351 52.367 1.00 37.76 ? 245 GLY A CA 1 ATOM 1354 C C . GLY A 1 179 ? 15.849 72.770 52.746 1.00 42.67 ? 245 GLY A C 1 ATOM 1355 O O . GLY A 1 179 ? 14.968 73.626 52.785 1.00 42.56 ? 245 GLY A O 1 ATOM 1356 N N . GLY A 1 180 ? 17.118 73.012 53.032 1.00 40.48 ? 246 GLY A N 1 ATOM 1357 C CA . GLY A 1 180 ? 17.587 74.330 53.421 1.00 40.33 ? 246 GLY A CA 1 ATOM 1358 C C . GLY A 1 180 ? 19.071 74.387 53.675 1.00 42.89 ? 246 GLY A C 1 ATOM 1359 O O . GLY A 1 180 ? 19.822 73.548 53.180 1.00 41.62 ? 246 GLY A O 1 ATOM 1360 N N . SER A 1 181 ? 19.494 75.418 54.425 1.00 38.78 ? 247 SER A N 1 ATOM 1361 C CA . SER A 1 181 ? 20.859 75.680 54.874 1.00 37.09 ? 247 SER A CA 1 ATOM 1362 C C . SER A 1 181 ? 20.887 75.911 56.370 1.00 41.27 ? 247 SER A C 1 ATOM 1363 O O . SER A 1 181 ? 19.863 76.299 56.940 1.00 42.13 ? 247 SER A O 1 ATOM 1364 C CB . SER A 1 181 ? 21.419 76.908 54.193 1.00 38.11 ? 247 SER A CB 1 ATOM 1365 O OG . SER A 1 181 ? 22.031 76.503 52.989 1.00 49.13 ? 247 SER A OG 1 ATOM 1366 N N . ASP A 1 182 ? 22.054 75.676 57.011 1.00 37.09 ? 248 ASP A N 1 ATOM 1367 C CA . ASP A 1 182 ? 22.208 75.894 58.443 1.00 36.69 ? 248 ASP A CA 1 ATOM 1368 C C . ASP A 1 182 ? 23.008 77.188 58.679 1.00 40.67 ? 248 ASP A C 1 ATOM 1369 O O . ASP A 1 182 ? 24.221 77.177 58.474 1.00 40.01 ? 248 ASP A O 1 ATOM 1370 C CB . ASP A 1 182 ? 22.847 74.681 59.143 1.00 37.70 ? 248 ASP A CB 1 ATOM 1371 C CG . ASP A 1 182 ? 22.809 74.747 60.658 1.00 40.26 ? 248 ASP A CG 1 ATOM 1372 O OD1 . ASP A 1 182 ? 22.509 75.821 61.199 1.00 42.72 ? 248 ASP A OD1 1 ATOM 1373 O OD2 . ASP A 1 182 ? 23.054 73.718 61.297 1.00 44.41 ? 248 ASP A OD2 1 ATOM 1374 N N . PRO A 1 183 ? 22.342 78.291 59.135 1.00 37.94 ? 249 PRO A N 1 ATOM 1375 C CA . PRO A 1 183 ? 23.066 79.562 59.381 1.00 37.30 ? 249 PRO A CA 1 ATOM 1376 C C . PRO A 1 183 ? 24.151 79.488 60.462 1.00 39.45 ? 249 PRO A C 1 ATOM 1377 O O . PRO A 1 183 ? 25.027 80.339 60.484 1.00 39.57 ? 249 PRO A O 1 ATOM 1378 C CB . PRO A 1 183 ? 21.950 80.565 59.742 1.00 39.16 ? 249 PRO A CB 1 ATOM 1379 C CG . PRO A 1 183 ? 20.672 79.916 59.326 1.00 43.75 ? 249 PRO A CG 1 ATOM 1380 C CD . PRO A 1 183 ? 20.897 78.438 59.433 1.00 39.33 ? 249 PRO A CD 1 ATOM 1381 N N . GLN A 1 184 ? 24.133 78.436 61.301 1.00 34.22 ? 250 GLN A N 1 ATOM 1382 C CA . GLN A 1 184 ? 25.144 78.193 62.322 1.00 32.82 ? 250 GLN A CA 1 ATOM 1383 C C . GLN A 1 184 ? 26.494 77.802 61.698 1.00 35.12 ? 250 GLN A C 1 ATOM 1384 O O . GLN A 1 184 ? 27.510 77.869 62.396 1.00 34.58 ? 250 GLN A O 1 ATOM 1385 C CB . GLN A 1 184 ? 24.673 77.080 63.284 1.00 33.76 ? 250 GLN A CB 1 ATOM 1386 N N . HIS A 1 185 ? 26.516 77.401 60.395 1.00 29.98 ? 251 HIS A N 1 ATOM 1387 C CA . HIS A 1 185 ? 27.758 76.922 59.762 1.00 29.91 ? 251 HIS A CA 1 ATOM 1388 C C . HIS A 1 185 ? 28.268 77.769 58.582 1.00 36.05 ? 251 HIS A C 1 ATOM 1389 O O . HIS A 1 185 ? 29.168 77.333 57.863 1.00 36.38 ? 251 HIS A O 1 ATOM 1390 C CB . HIS A 1 185 ? 27.651 75.426 59.386 1.00 29.63 ? 251 HIS A CB 1 ATOM 1391 C CG . HIS A 1 185 ? 27.711 74.573 60.614 1.00 32.52 ? 251 HIS A CG 1 ATOM 1392 N ND1 . HIS A 1 185 ? 28.754 74.714 61.546 1.00 34.35 ? 251 HIS A ND1 1 ATOM 1393 C CD2 . HIS A 1 185 ? 26.806 73.704 61.111 1.00 34.15 ? 251 HIS A CD2 1 ATOM 1394 C CE1 . HIS A 1 185 ? 28.470 73.891 62.544 1.00 33.15 ? 251 HIS A CE1 1 ATOM 1395 N NE2 . HIS A 1 185 ? 27.314 73.264 62.340 1.00 34.10 ? 251 HIS A NE2 1 ATOM 1396 N N . TYR A 1 186 ? 27.738 78.993 58.426 1.00 33.63 ? 252 TYR A N 1 ATOM 1397 C CA . TYR A 1 186 ? 28.220 79.985 57.459 1.00 33.02 ? 252 TYR A CA 1 ATOM 1398 C C . TYR A 1 186 ? 27.985 81.378 58.026 1.00 36.82 ? 252 TYR A C 1 ATOM 1399 O O . TYR A 1 186 ? 27.145 81.562 58.916 1.00 34.38 ? 252 TYR A O 1 ATOM 1400 C CB . TYR A 1 186 ? 27.584 79.845 56.061 1.00 33.19 ? 252 TYR A CB 1 ATOM 1401 C CG . TYR A 1 186 ? 26.103 80.143 55.993 1.00 34.58 ? 252 TYR A CG 1 ATOM 1402 C CD1 . TYR A 1 186 ? 25.640 81.435 55.748 1.00 35.25 ? 252 TYR A CD1 1 ATOM 1403 C CD2 . TYR A 1 186 ? 25.163 79.118 56.074 1.00 36.60 ? 252 TYR A CD2 1 ATOM 1404 C CE1 . TYR A 1 186 ? 24.275 81.709 55.635 1.00 34.42 ? 252 TYR A CE1 1 ATOM 1405 C CE2 . TYR A 1 186 ? 23.795 79.375 55.953 1.00 37.99 ? 252 TYR A CE2 1 ATOM 1406 C CZ . TYR A 1 186 ? 23.353 80.678 55.761 1.00 45.83 ? 252 TYR A CZ 1 ATOM 1407 O OH . TYR A 1 186 ? 21.998 80.926 55.673 1.00 46.48 ? 252 TYR A OH 1 ATOM 1408 N N . GLU A 1 187 ? 28.689 82.355 57.469 1.00 33.23 ? 253 GLU A N 1 ATOM 1409 C CA . GLU A 1 187 ? 28.520 83.755 57.831 1.00 32.06 ? 253 GLU A CA 1 ATOM 1410 C C . GLU A 1 187 ? 28.490 84.587 56.549 1.00 38.55 ? 253 GLU A C 1 ATOM 1411 O O . GLU A 1 187 ? 28.810 84.066 55.476 1.00 37.02 ? 253 GLU A O 1 ATOM 1412 C CB . GLU A 1 187 ? 29.589 84.225 58.838 1.00 32.97 ? 253 GLU A CB 1 ATOM 1413 C CG . GLU A 1 187 ? 31.020 83.895 58.446 1.00 35.49 ? 253 GLU A CG 1 ATOM 1414 C CD . GLU A 1 187 ? 32.025 84.151 59.539 1.00 42.47 ? 253 GLU A CD 1 ATOM 1415 O OE1 . GLU A 1 187 ? 31.612 84.374 60.700 1.00 34.29 ? 253 GLU A OE1 1 ATOM 1416 O OE2 . GLU A 1 187 ? 33.235 84.128 59.229 1.00 36.22 ? 253 GLU A OE2 1 ATOM 1417 N N . GLY A 1 188 ? 28.105 85.863 56.657 1.00 37.63 ? 254 GLY A N 1 ATOM 1418 C CA . GLY A 1 188 ? 27.913 86.731 55.503 1.00 36.93 ? 254 GLY A CA 1 ATOM 1419 C C . GLY A 1 188 ? 26.712 86.228 54.714 1.00 39.98 ? 254 GLY A C 1 ATOM 1420 O O . GLY A 1 188 ? 25.859 85.484 55.231 1.00 37.31 ? 254 GLY A O 1 ATOM 1421 N N . ASN A 1 189 ? 26.672 86.578 53.438 1.00 37.87 ? 255 ASN A N 1 ATOM 1422 C CA . ASN A 1 189 ? 25.583 86.107 52.591 1.00 38.15 ? 255 ASN A CA 1 ATOM 1423 C C . ASN A 1 189 ? 26.072 85.179 51.512 1.00 38.32 ? 255 ASN A C 1 ATOM 1424 O O . ASN A 1 189 ? 27.263 85.189 51.167 1.00 36.57 ? 255 ASN A O 1 ATOM 1425 C CB . ASN A 1 189 ? 24.820 87.296 51.961 1.00 45.87 ? 255 ASN A CB 1 ATOM 1426 C CG . ASN A 1 189 ? 24.121 88.166 52.970 1.00 68.74 ? 255 ASN A CG 1 ATOM 1427 O OD1 . ASN A 1 189 ? 24.546 89.285 53.211 1.00 58.94 ? 255 ASN A OD1 1 ATOM 1428 N ND2 . ASN A 1 189 ? 23.058 87.662 53.601 1.00 62.16 ? 255 ASN A ND2 1 ATOM 1429 N N . PHE A 1 190 ? 25.127 84.409 50.961 1.00 34.47 ? 256 PHE A N 1 ATOM 1430 C CA . PHE A 1 190 ? 25.344 83.514 49.854 1.00 35.14 ? 256 PHE A CA 1 ATOM 1431 C C . PHE A 1 190 ? 25.457 84.326 48.590 1.00 42.08 ? 256 PHE A C 1 ATOM 1432 O O . PHE A 1 190 ? 24.769 85.333 48.427 1.00 41.91 ? 256 PHE A O 1 ATOM 1433 C CB . PHE A 1 190 ? 24.167 82.533 49.723 1.00 36.79 ? 256 PHE A CB 1 ATOM 1434 C CG . PHE A 1 190 ? 24.227 81.296 50.593 1.00 38.84 ? 256 PHE A CG 1 ATOM 1435 C CD1 . PHE A 1 190 ? 25.195 80.315 50.376 1.00 42.36 ? 256 PHE A CD1 1 ATOM 1436 C CD2 . PHE A 1 190 ? 23.267 81.068 51.571 1.00 41.49 ? 256 PHE A CD2 1 ATOM 1437 C CE1 . PHE A 1 190 ? 25.235 79.160 51.162 1.00 43.11 ? 256 PHE A CE1 1 ATOM 1438 C CE2 . PHE A 1 190 ? 23.297 79.907 52.346 1.00 44.48 ? 256 PHE A CE2 1 ATOM 1439 C CZ . PHE A 1 190 ? 24.276 78.958 52.129 1.00 42.95 ? 256 PHE A CZ 1 ATOM 1440 N N . HIS A 1 191 ? 26.376 83.904 47.721 1.00 42.70 ? 257 HIS A N 1 ATOM 1441 C CA . HIS A 1 191 ? 26.620 84.430 46.380 1.00 44.13 ? 257 HIS A CA 1 ATOM 1442 C C . HIS A 1 191 ? 26.389 83.246 45.459 1.00 46.25 ? 257 HIS A C 1 ATOM 1443 O O . HIS A 1 191 ? 27.016 82.183 45.638 1.00 44.55 ? 257 HIS A O 1 ATOM 1444 C CB . HIS A 1 191 ? 28.023 85.064 46.248 1.00 46.88 ? 257 HIS A CB 1 ATOM 1445 C CG . HIS A 1 191 ? 28.158 86.290 47.111 1.00 52.55 ? 257 HIS A CG 1 ATOM 1446 N ND1 . HIS A 1 191 ? 28.941 86.287 48.268 1.00 55.35 ? 257 HIS A ND1 1 ATOM 1447 C CD2 . HIS A 1 191 ? 27.473 87.463 47.056 1.00 54.84 ? 257 HIS A CD2 1 ATOM 1448 C CE1 . HIS A 1 191 ? 28.743 87.467 48.837 1.00 54.79 ? 257 HIS A CE1 1 ATOM 1449 N NE2 . HIS A 1 191 ? 27.857 88.201 48.151 1.00 54.90 ? 257 HIS A NE2 1 ATOM 1450 N N . TYR A 1 192 ? 25.360 83.379 44.583 1.00 42.03 ? 258 TYR A N 1 ATOM 1451 C CA . TYR A 1 192 ? 24.947 82.323 43.666 1.00 40.66 ? 258 TYR A CA 1 ATOM 1452 C C . TYR A 1 192 ? 25.553 82.464 42.291 1.00 46.22 ? 258 TYR A C 1 ATOM 1453 O O . TYR A 1 192 ? 25.852 83.571 41.842 1.00 47.09 ? 258 TYR A O 1 ATOM 1454 C CB . TYR A 1 192 ? 23.423 82.179 43.595 1.00 40.20 ? 258 TYR A CB 1 ATOM 1455 C CG . TYR A 1 192 ? 22.788 81.925 44.940 1.00 40.31 ? 258 TYR A CG 1 ATOM 1456 C CD1 . TYR A 1 192 ? 22.449 82.980 45.781 1.00 42.15 ? 258 TYR A CD1 1 ATOM 1457 C CD2 . TYR A 1 192 ? 22.508 80.627 45.371 1.00 40.42 ? 258 TYR A CD2 1 ATOM 1458 C CE1 . TYR A 1 192 ? 21.851 82.756 47.018 1.00 41.79 ? 258 TYR A CE1 1 ATOM 1459 C CE2 . TYR A 1 192 ? 21.926 80.391 46.614 1.00 41.18 ? 258 TYR A CE2 1 ATOM 1460 C CZ . TYR A 1 192 ? 21.594 81.462 47.433 1.00 48.45 ? 258 TYR A CZ 1 ATOM 1461 O OH . TYR A 1 192 ? 21.005 81.257 48.662 1.00 52.96 ? 258 TYR A OH 1 ATOM 1462 N N . ILE A 1 193 ? 25.850 81.316 41.687 1.00 42.60 ? 259 ILE A N 1 ATOM 1463 C CA . ILE A 1 193 ? 26.374 81.153 40.339 1.00 41.96 ? 259 ILE A CA 1 ATOM 1464 C C . ILE A 1 193 ? 25.403 80.165 39.708 1.00 46.06 ? 259 ILE A C 1 ATOM 1465 O O . ILE A 1 193 ? 25.137 79.110 40.285 1.00 45.52 ? 259 ILE A O 1 ATOM 1466 C CB . ILE A 1 193 ? 27.840 80.650 40.294 1.00 45.24 ? 259 ILE A CB 1 ATOM 1467 C CG1 . ILE A 1 193 ? 28.795 81.495 41.204 1.00 46.83 ? 259 ILE A CG1 1 ATOM 1468 C CG2 . ILE A 1 193 ? 28.343 80.607 38.848 1.00 43.25 ? 259 ILE A CG2 1 ATOM 1469 C CD1 . ILE A 1 193 ? 29.093 80.896 42.567 1.00 50.34 ? 259 ILE A CD1 1 ATOM 1470 N N . ASN A 1 194 ? 24.829 80.519 38.562 1.00 43.44 ? 260 ASN A N 1 ATOM 1471 C CA . ASN A 1 194 ? 23.872 79.643 37.881 1.00 42.92 ? 260 ASN A CA 1 ATOM 1472 C C . ASN A 1 194 ? 24.588 78.462 37.247 1.00 44.63 ? 260 ASN A C 1 ATOM 1473 O O . ASN A 1 194 ? 25.781 78.562 36.925 1.00 43.70 ? 260 ASN A O 1 ATOM 1474 C CB . ASN A 1 194 ? 23.068 80.403 36.809 1.00 43.45 ? 260 ASN A CB 1 ATOM 1475 C CG . ASN A 1 194 ? 22.223 81.519 37.364 1.00 70.99 ? 260 ASN A CG 1 ATOM 1476 O OD1 . ASN A 1 194 ? 21.029 81.362 37.654 1.00 57.04 ? 260 ASN A OD1 1 ATOM 1477 N ND2 . ASN A 1 194 ? 22.850 82.663 37.548 1.00 74.95 ? 260 ASN A ND2 1 ATOM 1478 N N . LEU A 1 195 ? 23.860 77.344 37.063 1.00 39.04 ? 261 LEU A N 1 ATOM 1479 C CA . LEU A 1 195 ? 24.429 76.169 36.416 1.00 38.46 ? 261 LEU A CA 1 ATOM 1480 C C . LEU A 1 195 ? 24.545 76.450 34.928 1.00 44.88 ? 261 LEU A C 1 ATOM 1481 O O . LEU A 1 195 ? 23.683 77.139 34.375 1.00 45.73 ? 261 LEU A O 1 ATOM 1482 C CB . LEU A 1 195 ? 23.542 74.915 36.642 1.00 37.59 ? 261 LEU A CB 1 ATOM 1483 C CG . LEU A 1 195 ? 23.352 74.405 38.095 1.00 40.54 ? 261 LEU A CG 1 ATOM 1484 C CD1 . LEU A 1 195 ? 22.575 73.114 38.126 1.00 40.50 ? 261 LEU A CD1 1 ATOM 1485 C CD2 . LEU A 1 195 ? 24.675 74.233 38.820 1.00 40.35 ? 261 LEU A CD2 1 ATOM 1486 N N . ILE A 1 196 ? 25.591 75.916 34.278 1.00 43.62 ? 262 ILE A N 1 ATOM 1487 C CA . ILE A 1 196 ? 25.766 75.997 32.829 1.00 45.67 ? 262 ILE A CA 1 ATOM 1488 C C . ILE A 1 196 ? 24.463 75.450 32.197 1.00 54.40 ? 262 ILE A C 1 ATOM 1489 O O . ILE A 1 196 ? 23.853 76.102 31.342 1.00 55.63 ? 262 ILE A O 1 ATOM 1490 C CB . ILE A 1 196 ? 26.993 75.156 32.403 1.00 48.91 ? 262 ILE A CB 1 ATOM 1491 C CG1 . ILE A 1 196 ? 28.331 75.793 32.889 1.00 48.97 ? 262 ILE A CG1 1 ATOM 1492 C CG2 . ILE A 1 196 ? 26.993 74.843 30.886 1.00 49.71 ? 262 ILE A CG2 1 ATOM 1493 C CD1 . ILE A 1 196 ? 28.754 77.040 32.245 1.00 58.99 ? 262 ILE A CD1 1 ATOM 1494 N N . LYS A 1 197 ? 24.012 74.287 32.694 1.00 52.48 ? 263 LYS A N 1 ATOM 1495 C CA . LYS A 1 197 ? 22.788 73.597 32.284 1.00 53.00 ? 263 LYS A CA 1 ATOM 1496 C C . LYS A 1 197 ? 22.311 72.708 33.417 1.00 59.58 ? 263 LYS A C 1 ATOM 1497 O O . LYS A 1 197 ? 23.135 72.212 34.204 1.00 60.63 ? 263 LYS A O 1 ATOM 1498 C CB . LYS A 1 197 ? 23.033 72.724 31.029 1.00 54.79 ? 263 LYS A CB 1 ATOM 1499 C CG . LYS A 1 197 ? 24.094 71.641 31.202 1.00 61.53 ? 263 LYS A CG 1 ATOM 1500 C CD . LYS A 1 197 ? 24.186 70.719 29.995 1.00 71.66 ? 263 LYS A CD 1 ATOM 1501 C CE . LYS A 1 197 ? 25.365 69.777 30.111 1.00 81.93 ? 263 LYS A CE 1 ATOM 1502 N NZ . LYS A 1 197 ? 26.670 70.501 30.089 1.00 88.82 ? 263 LYS A NZ 1 ATOM 1503 N N . THR A 1 198 ? 20.993 72.449 33.464 1.00 55.58 ? 264 THR A N 1 ATOM 1504 C CA . THR A 1 198 ? 20.394 71.518 34.423 1.00 54.55 ? 264 THR A CA 1 ATOM 1505 C C . THR A 1 198 ? 20.952 70.098 34.094 1.00 54.76 ? 264 THR A C 1 ATOM 1506 O O . THR A 1 198 ? 21.389 69.848 32.963 1.00 54.24 ? 264 THR A O 1 ATOM 1507 C CB . THR A 1 198 ? 18.845 71.664 34.431 1.00 62.55 ? 264 THR A CB 1 ATOM 1508 O OG1 . THR A 1 198 ? 18.301 71.068 35.607 1.00 57.12 ? 264 THR A OG1 1 ATOM 1509 C CG2 . THR A 1 198 ? 18.172 71.090 33.174 1.00 64.74 ? 264 THR A CG2 1 ATOM 1510 N N . GLY A 1 199 ? 21.021 69.232 35.096 1.00 47.63 ? 265 GLY A N 1 ATOM 1511 C CA . GLY A 1 199 ? 21.564 67.896 34.887 1.00 45.35 ? 265 GLY A CA 1 ATOM 1512 C C . GLY A 1 199 ? 22.965 67.669 35.420 1.00 43.57 ? 265 GLY A C 1 ATOM 1513 O O . GLY A 1 199 ? 23.356 66.527 35.593 1.00 41.92 ? 265 GLY A O 1 ATOM 1514 N N . VAL A 1 200 ? 23.733 68.737 35.684 1.00 38.47 ? 266 VAL A N 1 ATOM 1515 C CA . VAL A 1 200 ? 25.101 68.653 36.207 1.00 38.19 ? 266 VAL A CA 1 ATOM 1516 C C . VAL A 1 200 ? 25.335 69.779 37.233 1.00 43.29 ? 266 VAL A C 1 ATOM 1517 O O . VAL A 1 200 ? 25.008 70.929 36.937 1.00 45.11 ? 266 VAL A O 1 ATOM 1518 C CB . VAL A 1 200 ? 26.193 68.712 35.103 1.00 41.36 ? 266 VAL A CB 1 ATOM 1519 C CG1 . VAL A 1 200 ? 27.512 68.145 35.615 1.00 40.88 ? 266 VAL A CG1 1 ATOM 1520 C CG2 . VAL A 1 200 ? 25.780 67.986 33.829 1.00 41.25 ? 266 VAL A CG2 1 ATOM 1521 N N . TRP A 1 201 ? 25.948 69.471 38.410 1.00 37.54 ? 267 TRP A N 1 ATOM 1522 C CA . TRP A 1 201 ? 26.295 70.507 39.414 1.00 35.86 ? 267 TRP A CA 1 ATOM 1523 C C . TRP A 1 201 ? 27.619 71.128 38.985 1.00 39.40 ? 267 TRP A C 1 ATOM 1524 O O . TRP A 1 201 ? 28.651 70.961 39.644 1.00 38.67 ? 267 TRP A O 1 ATOM 1525 C CB . TRP A 1 201 ? 26.350 69.960 40.860 1.00 32.60 ? 267 TRP A CB 1 ATOM 1526 C CG . TRP A 1 201 ? 25.026 69.516 41.405 1.00 32.35 ? 267 TRP A CG 1 ATOM 1527 C CD1 . TRP A 1 201 ? 24.644 68.237 41.690 1.00 34.66 ? 267 TRP A CD1 1 ATOM 1528 C CD2 . TRP A 1 201 ? 23.903 70.357 41.732 1.00 32.11 ? 267 TRP A CD2 1 ATOM 1529 N NE1 . TRP A 1 201 ? 23.363 68.227 42.196 1.00 33.57 ? 267 TRP A NE1 1 ATOM 1530 C CE2 . TRP A 1 201 ? 22.880 69.514 42.222 1.00 35.15 ? 267 TRP A CE2 1 ATOM 1531 C CE3 . TRP A 1 201 ? 23.659 71.747 41.640 1.00 33.03 ? 267 TRP A CE3 1 ATOM 1532 C CZ2 . TRP A 1 201 ? 21.639 70.014 42.645 1.00 34.22 ? 267 TRP A CZ2 1 ATOM 1533 C CZ3 . TRP A 1 201 ? 22.430 72.242 42.042 1.00 34.06 ? 267 TRP A CZ3 1 ATOM 1534 C CH2 . TRP A 1 201 ? 21.437 71.382 42.551 1.00 34.58 ? 267 TRP A CH2 1 ATOM 1535 N N . GLN A 1 202 ? 27.573 71.812 37.827 1.00 36.12 ? 268 GLN A N 1 ATOM 1536 C CA . GLN A 1 202 ? 28.721 72.410 37.148 1.00 35.93 ? 268 GLN A CA 1 ATOM 1537 C C . GLN A 1 202 ? 28.420 73.848 36.756 1.00 39.50 ? 268 GLN A C 1 ATOM 1538 O O . GLN A 1 202 ? 27.342 74.145 36.233 1.00 40.61 ? 268 GLN A O 1 ATOM 1539 C CB . GLN A 1 202 ? 29.074 71.574 35.912 1.00 36.89 ? 268 GLN A CB 1 ATOM 1540 C CG . GLN A 1 202 ? 30.394 71.939 35.259 1.00 34.33 ? 268 GLN A CG 1 ATOM 1541 C CD . GLN A 1 202 ? 30.694 71.001 34.135 1.00 50.56 ? 268 GLN A CD 1 ATOM 1542 O OE1 . GLN A 1 202 ? 29.858 70.726 33.278 1.00 51.56 ? 268 GLN A OE1 1 ATOM 1543 N NE2 . GLN A 1 202 ? 31.879 70.449 34.144 1.00 43.50 ? 268 GLN A NE2 1 ATOM 1544 N N . ILE A 1 203 ? 29.377 74.739 37.032 1.00 34.16 ? 269 ILE A N 1 ATOM 1545 C CA . ILE A 1 203 ? 29.259 76.169 36.769 1.00 33.30 ? 269 ILE A CA 1 ATOM 1546 C C . ILE A 1 203 ? 30.431 76.666 35.923 1.00 41.92 ? 269 ILE A C 1 ATOM 1547 O O . ILE A 1 203 ? 31.462 75.989 35.823 1.00 42.60 ? 269 ILE A O 1 ATOM 1548 C CB . ILE A 1 203 ? 29.155 76.962 38.107 1.00 34.25 ? 269 ILE A CB 1 ATOM 1549 C CG1 . ILE A 1 203 ? 30.447 76.773 38.991 1.00 34.36 ? 269 ILE A CG1 1 ATOM 1550 C CG2 . ILE A 1 203 ? 27.861 76.643 38.846 1.00 31.66 ? 269 ILE A CG2 1 ATOM 1551 C CD1 . ILE A 1 203 ? 30.482 77.460 40.390 1.00 29.95 ? 269 ILE A CD1 1 ATOM 1552 N N . GLN A 1 204 ? 30.285 77.876 35.355 1.00 40.55 ? 270 GLN A N 1 ATOM 1553 C CA . GLN A 1 204 ? 31.340 78.546 34.600 1.00 40.76 ? 270 GLN A CA 1 ATOM 1554 C C . GLN A 1 204 ? 32.350 79.134 35.592 1.00 46.05 ? 270 GLN A C 1 ATOM 1555 O O . GLN A 1 204 ? 31.965 79.747 36.596 1.00 45.79 ? 270 GLN A O 1 ATOM 1556 C CB . GLN A 1 204 ? 30.732 79.679 33.735 1.00 42.01 ? 270 GLN A CB 1 ATOM 1557 C CG . GLN A 1 204 ? 31.688 80.348 32.726 1.00 51.93 ? 270 GLN A CG 1 ATOM 1558 C CD . GLN A 1 204 ? 32.227 79.440 31.638 1.00 71.77 ? 270 GLN A CD 1 ATOM 1559 O OE1 . GLN A 1 204 ? 31.546 78.543 31.131 1.00 70.04 ? 270 GLN A OE1 1 ATOM 1560 N NE2 . GLN A 1 204 ? 33.459 79.689 31.221 1.00 65.42 ? 270 GLN A NE2 1 ATOM 1561 N N . MET A 1 205 ? 33.636 78.935 35.311 1.00 42.95 ? 271 MET A N 1 ATOM 1562 C CA . MET A 1 205 ? 34.721 79.520 36.085 1.00 43.36 ? 271 MET A CA 1 ATOM 1563 C C . MET A 1 205 ? 35.439 80.522 35.146 1.00 52.90 ? 271 MET A C 1 ATOM 1564 O O . MET A 1 205 ? 35.798 80.165 34.014 1.00 53.52 ? 271 MET A O 1 ATOM 1565 C CB . MET A 1 205 ? 35.659 78.451 36.663 1.00 44.54 ? 271 MET A CB 1 ATOM 1566 C CG . MET A 1 205 ? 36.775 79.029 37.526 1.00 46.66 ? 271 MET A CG 1 ATOM 1567 S SD . MET A 1 205 ? 37.377 77.927 38.816 1.00 48.69 ? 271 MET A SD 1 ATOM 1568 C CE . MET A 1 205 ? 37.907 76.578 37.870 1.00 44.18 ? 271 MET A CE 1 ATOM 1569 N N . LYS A 1 206 ? 35.588 81.780 35.607 1.00 50.84 ? 272 LYS A N 1 ATOM 1570 C CA . LYS A 1 206 ? 36.140 82.896 34.830 1.00 50.73 ? 272 LYS A CA 1 ATOM 1571 C C . LYS A 1 206 ? 37.664 82.944 34.761 1.00 55.95 ? 272 LYS A C 1 ATOM 1572 O O . LYS A 1 206 ? 38.195 83.509 33.804 1.00 58.70 ? 272 LYS A O 1 ATOM 1573 C CB . LYS A 1 206 ? 35.571 84.233 35.329 1.00 52.51 ? 272 LYS A CB 1 ATOM 1574 C CG . LYS A 1 206 ? 34.049 84.348 35.134 1.00 59.49 ? 272 LYS A CG 1 ATOM 1575 C CD . LYS A 1 206 ? 33.441 85.516 35.900 1.00 68.00 ? 272 LYS A CD 1 ATOM 1576 C CE . LYS A 1 206 ? 31.987 85.730 35.555 1.00 77.66 ? 272 LYS A CE 1 ATOM 1577 N NZ . LYS A 1 206 ? 31.495 87.057 36.021 1.00 81.26 ? 272 LYS A NZ 1 ATOM 1578 N N . GLY A 1 207 ? 38.343 82.341 35.737 1.00 50.39 ? 273 GLY A N 1 ATOM 1579 C CA . GLY A 1 207 ? 39.800 82.300 35.820 1.00 48.64 ? 273 GLY A CA 1 ATOM 1580 C C . GLY A 1 207 ? 40.309 81.736 37.127 1.00 51.51 ? 273 GLY A C 1 ATOM 1581 O O . GLY A 1 207 ? 39.581 81.736 38.117 1.00 51.85 ? 273 GLY A O 1 ATOM 1582 N N . VAL A 1 208 ? 41.562 81.236 37.135 1.00 47.58 ? 274 VAL A N 1 ATOM 1583 C CA . VAL A 1 208 ? 42.253 80.671 38.306 1.00 47.58 ? 274 VAL A CA 1 ATOM 1584 C C . VAL A 1 208 ? 43.596 81.406 38.496 1.00 56.12 ? 274 VAL A C 1 ATOM 1585 O O . VAL A 1 208 ? 44.466 81.328 37.630 1.00 56.83 ? 274 VAL A O 1 ATOM 1586 C CB . VAL A 1 208 ? 42.439 79.118 38.244 1.00 49.28 ? 274 VAL A CB 1 ATOM 1587 C CG1 . VAL A 1 208 ? 43.012 78.575 39.551 1.00 48.62 ? 274 VAL A CG1 1 ATOM 1588 C CG2 . VAL A 1 208 ? 41.131 78.415 37.919 1.00 48.58 ? 274 VAL A CG2 1 ATOM 1589 N N . SER A 1 209 ? 43.769 82.086 39.637 1.00 55.50 ? 275 SER A N 1 ATOM 1590 C CA . SER A 1 209 ? 44.991 82.838 39.957 1.00 56.69 ? 275 SER A CA 1 ATOM 1591 C C . SER A 1 209 ? 45.864 82.182 41.027 1.00 62.37 ? 275 SER A C 1 ATOM 1592 O O . SER A 1 209 ? 45.361 81.771 42.065 1.00 62.86 ? 275 SER A O 1 ATOM 1593 C CB . SER A 1 209 ? 44.649 84.257 40.402 1.00 62.06 ? 275 SER A CB 1 ATOM 1594 O OG . SER A 1 209 ? 43.502 84.766 39.730 1.00 76.36 ? 275 SER A OG 1 ATOM 1595 N N . VAL A 1 210 ? 47.173 82.101 40.771 1.00 60.51 ? 276 VAL A N 1 ATOM 1596 C CA . VAL A 1 210 ? 48.148 81.581 41.727 1.00 61.78 ? 276 VAL A CA 1 ATOM 1597 C C . VAL A 1 210 ? 49.043 82.759 42.073 1.00 72.01 ? 276 VAL A C 1 ATOM 1598 O O . VAL A 1 210 ? 49.896 83.131 41.266 1.00 72.07 ? 276 VAL A O 1 ATOM 1599 C CB . VAL A 1 210 ? 48.943 80.352 41.231 1.00 64.95 ? 276 VAL A CB 1 ATOM 1600 C CG1 . VAL A 1 210 ? 49.763 79.739 42.366 1.00 64.48 ? 276 VAL A CG1 1 ATOM 1601 C CG2 . VAL A 1 210 ? 48.013 79.319 40.617 1.00 64.50 ? 276 VAL A CG2 1 ATOM 1602 N N . GLY A 1 211 ? 48.769 83.379 43.228 1.00 73.12 ? 277 GLY A N 1 ATOM 1603 C CA . GLY A 1 211 ? 49.458 84.566 43.708 1.00 74.81 ? 277 GLY A CA 1 ATOM 1604 C C . GLY A 1 211 ? 49.151 85.768 42.839 1.00 83.66 ? 277 GLY A C 1 ATOM 1605 O O . GLY A 1 211 ? 47.984 86.070 42.545 1.00 84.09 ? 277 GLY A O 1 ATOM 1606 N N . SER A 1 212 ? 50.225 86.457 42.410 1.00 82.68 ? 278 SER A N 1 ATOM 1607 C CA . SER A 1 212 ? 50.123 87.652 41.566 1.00 83.73 ? 278 SER A CA 1 ATOM 1608 C C . SER A 1 212 ? 50.404 87.337 40.096 1.00 89.00 ? 278 SER A C 1 ATOM 1609 O O . SER A 1 212 ? 49.540 87.580 39.239 1.00 89.00 ? 278 SER A O 1 ATOM 1610 C CB . SER A 1 212 ? 51.048 88.765 42.068 1.00 87.95 ? 278 SER A CB 1 ATOM 1611 O OG . SER A 1 212 ? 52.395 88.328 42.176 1.00 97.57 ? 278 SER A OG 1 ATOM 1612 N N . SER A 1 213 ? 51.623 86.794 39.809 1.00 85.46 ? 279 SER A N 1 ATOM 1613 C CA . SER A 1 213 ? 52.159 86.527 38.464 1.00 84.93 ? 279 SER A CA 1 ATOM 1614 C C . SER A 1 213 ? 51.529 85.346 37.684 1.00 85.84 ? 279 SER A C 1 ATOM 1615 O O . SER A 1 213 ? 51.372 85.490 36.468 1.00 86.05 ? 279 SER A O 1 ATOM 1616 C CB . SER A 1 213 ? 53.684 86.378 38.488 1.00 89.07 ? 279 SER A CB 1 ATOM 1617 O OG . SER A 1 213 ? 54.171 85.453 39.448 1.00 98.65 ? 279 SER A OG 1 ATOM 1618 N N . THR A 1 214 ? 51.182 84.205 38.332 1.00 79.19 ? 280 THR A N 1 ATOM 1619 C CA . THR A 1 214 ? 50.620 83.048 37.600 1.00 77.51 ? 280 THR A CA 1 ATOM 1620 C C . THR A 1 214 ? 49.085 83.180 37.357 1.00 78.87 ? 280 THR A C 1 ATOM 1621 O O . THR A 1 214 ? 48.339 83.622 38.242 1.00 79.42 ? 280 THR A O 1 ATOM 1622 C CB . THR A 1 214 ? 51.022 81.712 38.257 1.00 80.52 ? 280 THR A CB 1 ATOM 1623 O OG1 . THR A 1 214 ? 52.433 81.719 38.530 1.00 80.94 ? 280 THR A OG1 1 ATOM 1624 C CG2 . THR A 1 214 ? 50.664 80.499 37.395 1.00 73.52 ? 280 THR A CG2 1 ATOM 1625 N N . LEU A 1 215 ? 48.644 82.803 36.134 1.00 71.25 ? 281 LEU A N 1 ATOM 1626 C CA . LEU A 1 215 ? 47.254 82.860 35.684 1.00 69.18 ? 281 LEU A CA 1 ATOM 1627 C C . LEU A 1 215 ? 46.901 81.645 34.832 1.00 69.09 ? 281 LEU A C 1 ATOM 1628 O O . LEU A 1 215 ? 47.669 81.260 33.947 1.00 69.31 ? 281 LEU A O 1 ATOM 1629 C CB . LEU A 1 215 ? 47.026 84.141 34.873 1.00 69.30 ? 281 LEU A CB 1 ATOM 1630 C CG . LEU A 1 215 ? 46.012 85.122 35.426 1.00 74.08 ? 281 LEU A CG 1 ATOM 1631 C CD1 . LEU A 1 215 ? 46.592 85.931 36.593 1.00 74.20 ? 281 LEU A CD1 1 ATOM 1632 C CD2 . LEU A 1 215 ? 45.529 86.047 34.334 1.00 76.95 ? 281 LEU A CD2 1 ATOM 1633 N N . LEU A 1 216 ? 45.735 81.040 35.113 1.00 61.65 ? 282 LEU A N 1 ATOM 1634 C CA . LEU A 1 216 ? 45.199 79.854 34.434 1.00 59.38 ? 282 LEU A CA 1 ATOM 1635 C C . LEU A 1 216 ? 43.718 80.081 34.174 1.00 59.84 ? 282 LEU A C 1 ATOM 1636 O O . LEU A 1 216 ? 43.161 81.038 34.725 1.00 57.87 ? 282 LEU A O 1 ATOM 1637 C CB . LEU A 1 216 ? 45.383 78.610 35.313 1.00 59.12 ? 282 LEU A CB 1 ATOM 1638 C CG . LEU A 1 216 ? 46.808 78.180 35.564 1.00 63.21 ? 282 LEU A CG 1 ATOM 1639 C CD1 . LEU A 1 216 ? 47.178 78.370 37.009 1.00 62.97 ? 282 LEU A CD1 1 ATOM 1640 C CD2 . LEU A 1 216 ? 47.007 76.759 35.141 1.00 65.98 ? 282 LEU A CD2 1 ATOM 1641 N N . CYS A 1 217 ? 43.079 79.240 33.311 1.00 55.75 ? 283 CYS A N 1 ATOM 1642 C CA . CYS A 1 217 ? 41.652 79.370 32.969 1.00 56.00 ? 283 CYS A CA 1 ATOM 1643 C C . CYS A 1 217 ? 41.363 80.828 32.481 1.00 61.54 ? 283 CYS A C 1 ATOM 1644 O O . CYS A 1 217 ? 40.276 81.382 32.660 1.00 61.08 ? 283 CYS A O 1 ATOM 1645 C CB . CYS A 1 217 ? 40.793 78.958 34.168 1.00 56.12 ? 283 CYS A CB 1 ATOM 1646 S SG . CYS A 1 217 ? 39.000 79.038 33.906 1.00 59.85 ? 283 CYS A SG 1 ATOM 1647 N N . GLU A 1 218 ? 42.382 81.418 31.822 1.00 60.49 ? 284 GLU A N 1 ATOM 1648 C CA . GLU A 1 218 ? 42.428 82.781 31.285 1.00 60.79 ? 284 GLU A CA 1 ATOM 1649 C C . GLU A 1 218 ? 41.294 83.084 30.309 1.00 64.80 ? 284 GLU A C 1 ATOM 1650 O O . GLU A 1 218 ? 40.795 84.209 30.310 1.00 64.03 ? 284 GLU A O 1 ATOM 1651 C CB . GLU A 1 218 ? 43.806 83.068 30.664 1.00 62.46 ? 284 GLU A CB 1 ATOM 1652 C CG . GLU A 1 218 ? 44.962 82.956 31.654 1.00 75.86 ? 284 GLU A CG 1 ATOM 1653 C CD . GLU A 1 218 ? 46.364 83.050 31.077 1.00 96.05 ? 284 GLU A CD 1 ATOM 1654 O OE1 . GLU A 1 218 ? 46.733 84.146 30.595 1.00 76.47 ? 284 GLU A OE1 1 ATOM 1655 O OE2 . GLU A 1 218 ? 47.110 82.044 31.149 1.00 90.59 ? 284 GLU A OE2 1 ATOM 1656 N N . ASP A 1 219 ? 40.849 82.072 29.522 1.00 62.42 ? 285 ASP A N 1 ATOM 1657 C CA . ASP A 1 219 ? 39.750 82.227 28.564 1.00 62.98 ? 285 ASP A CA 1 ATOM 1658 C C . ASP A 1 219 ? 38.445 81.552 29.041 1.00 65.74 ? 285 ASP A C 1 ATOM 1659 O O . ASP A 1 219 ? 37.537 81.295 28.237 1.00 64.73 ? 285 ASP A O 1 ATOM 1660 C CB . ASP A 1 219 ? 40.179 81.748 27.157 1.00 66.21 ? 285 ASP A CB 1 ATOM 1661 C CG . ASP A 1 219 ? 41.368 82.493 26.567 1.00 85.35 ? 285 ASP A CG 1 ATOM 1662 O OD1 . ASP A 1 219 ? 41.339 83.758 26.552 1.00 87.50 ? 285 ASP A OD1 1 ATOM 1663 O OD2 . ASP A 1 219 ? 42.328 81.818 26.115 1.00 92.91 ? 285 ASP A OD2 1 ATOM 1664 N N . GLY A 1 220 ? 38.361 81.292 30.351 1.00 61.30 ? 286 GLY A N 1 ATOM 1665 C CA . GLY A 1 220 ? 37.211 80.639 30.964 1.00 59.91 ? 286 GLY A CA 1 ATOM 1666 C C . GLY A 1 220 ? 37.282 79.128 30.906 1.00 60.76 ? 286 GLY A C 1 ATOM 1667 O O . GLY A 1 220 ? 37.944 78.556 30.034 1.00 59.27 ? 286 GLY A O 1 ATOM 1668 N N . CYS A 1 221 ? 36.632 78.474 31.881 1.00 56.53 ? 287 CYS A N 1 ATOM 1669 C CA . CYS A 1 221 ? 36.597 77.019 32.023 1.00 55.25 ? 287 CYS A CA 1 ATOM 1670 C C . CYS A 1 221 ? 35.394 76.566 32.844 1.00 56.90 ? 287 CYS A C 1 ATOM 1671 O O . CYS A 1 221 ? 34.525 77.374 33.184 1.00 56.93 ? 287 CYS A O 1 ATOM 1672 C CB . CYS A 1 221 ? 37.914 76.477 32.582 1.00 55.62 ? 287 CYS A CB 1 ATOM 1673 S SG . CYS A 1 221 ? 38.366 77.129 34.214 1.00 59.89 ? 287 CYS A SG 1 ATOM 1674 N N . LEU A 1 222 ? 35.318 75.266 33.124 1.00 51.20 ? 288 LEU A N 1 ATOM 1675 C CA . LEU A 1 222 ? 34.209 74.696 33.881 1.00 48.67 ? 288 LEU A CA 1 ATOM 1676 C C . LEU A 1 222 ? 34.653 74.270 35.275 1.00 46.40 ? 288 LEU A C 1 ATOM 1677 O O . LEU A 1 222 ? 35.819 73.938 35.493 1.00 43.73 ? 288 LEU A O 1 ATOM 1678 C CB . LEU A 1 222 ? 33.601 73.499 33.124 1.00 48.17 ? 288 LEU A CB 1 ATOM 1679 C CG . LEU A 1 222 ? 33.149 73.720 31.681 1.00 51.30 ? 288 LEU A CG 1 ATOM 1680 C CD1 . LEU A 1 222 ? 32.719 72.422 31.060 1.00 50.64 ? 288 LEU A CD1 1 ATOM 1681 C CD2 . LEU A 1 222 ? 32.016 74.716 31.603 1.00 52.92 ? 288 LEU A CD2 1 ATOM 1682 N N . ALA A 1 223 ? 33.712 74.307 36.223 1.00 40.29 ? 289 ALA A N 1 ATOM 1683 C CA . ALA A 1 223 ? 33.941 73.881 37.599 1.00 38.26 ? 289 ALA A CA 1 ATOM 1684 C C . ALA A 1 223 ? 32.791 73.005 38.085 1.00 39.25 ? 289 ALA A C 1 ATOM 1685 O O . ALA A 1 223 ? 31.661 73.476 38.235 1.00 38.43 ? 289 ALA A O 1 ATOM 1686 C CB . ALA A 1 223 ? 34.152 75.083 38.525 1.00 38.35 ? 289 ALA A CB 1 ATOM 1687 N N . LEU A 1 224 ? 33.068 71.708 38.266 1.00 36.54 ? 290 LEU A N 1 ATOM 1688 C CA . LEU A 1 224 ? 32.094 70.758 38.820 1.00 36.76 ? 290 LEU A CA 1 ATOM 1689 C C . LEU A 1 224 ? 32.206 70.861 40.352 1.00 39.43 ? 290 LEU A C 1 ATOM 1690 O O . LEU A 1 224 ? 33.317 70.792 40.873 1.00 41.34 ? 290 LEU A O 1 ATOM 1691 C CB . LEU A 1 224 ? 32.388 69.326 38.337 1.00 37.12 ? 290 LEU A CB 1 ATOM 1692 C CG . LEU A 1 224 ? 31.461 68.255 38.896 1.00 42.44 ? 290 LEU A CG 1 ATOM 1693 C CD1 . LEU A 1 224 ? 30.155 68.236 38.156 1.00 42.35 ? 290 LEU A CD1 1 ATOM 1694 C CD2 . LEU A 1 224 ? 32.131 66.907 38.887 1.00 44.31 ? 290 LEU A CD2 1 ATOM 1695 N N . VAL A 1 225 ? 31.098 71.125 41.060 1.00 33.21 ? 291 VAL A N 1 ATOM 1696 C CA . VAL A 1 225 ? 31.132 71.257 42.524 1.00 32.46 ? 291 VAL A CA 1 ATOM 1697 C C . VAL A 1 225 ? 30.804 69.873 43.084 1.00 36.01 ? 291 VAL A C 1 ATOM 1698 O O . VAL A 1 225 ? 29.644 69.442 43.072 1.00 35.00 ? 291 VAL A O 1 ATOM 1699 C CB . VAL A 1 225 ? 30.248 72.417 43.051 1.00 35.83 ? 291 VAL A CB 1 ATOM 1700 C CG1 . VAL A 1 225 ? 30.413 72.579 44.553 1.00 35.67 ? 291 VAL A CG1 1 ATOM 1701 C CG2 . VAL A 1 225 ? 30.613 73.724 42.359 1.00 35.05 ? 291 VAL A CG2 1 ATOM 1702 N N . ASP A 1 226 ? 31.865 69.138 43.459 1.00 32.47 ? 292 ASP A N 1 ATOM 1703 C CA . ASP A 1 226 ? 31.800 67.717 43.816 1.00 31.93 ? 292 ASP A CA 1 ATOM 1704 C C . ASP A 1 226 ? 32.028 67.419 45.294 1.00 33.69 ? 292 ASP A C 1 ATOM 1705 O O . ASP A 1 226 ? 33.158 67.425 45.761 1.00 33.69 ? 292 ASP A O 1 ATOM 1706 C CB . ASP A 1 226 ? 32.790 66.932 42.919 1.00 33.79 ? 292 ASP A CB 1 ATOM 1707 C CG . ASP A 1 226 ? 32.609 65.435 42.866 1.00 42.77 ? 292 ASP A CG 1 ATOM 1708 O OD1 . ASP A 1 226 ? 31.684 64.926 43.533 1.00 44.77 ? 292 ASP A OD1 1 ATOM 1709 O OD2 . ASP A 1 226 ? 33.405 64.759 42.156 1.00 40.56 ? 292 ASP A OD2 1 ATOM 1710 N N . THR A 1 227 ? 30.951 67.078 46.006 1.00 30.20 ? 293 THR A N 1 ATOM 1711 C CA . THR A 1 227 ? 30.990 66.753 47.442 1.00 29.74 ? 293 THR A CA 1 ATOM 1712 C C . THR A 1 227 ? 31.675 65.399 47.731 1.00 33.14 ? 293 THR A C 1 ATOM 1713 O O . THR A 1 227 ? 32.178 65.178 48.836 1.00 32.80 ? 293 THR A O 1 ATOM 1714 C CB . THR A 1 227 ? 29.603 66.856 48.056 1.00 30.95 ? 293 THR A CB 1 ATOM 1715 O OG1 . THR A 1 227 ? 28.722 65.964 47.374 1.00 29.07 ? 293 THR A OG1 1 ATOM 1716 C CG2 . THR A 1 227 ? 29.060 68.268 47.995 1.00 26.27 ? 293 THR A CG2 1 ATOM 1717 N N . GLY A 1 228 ? 31.719 64.541 46.718 1.00 29.70 ? 294 GLY A N 1 ATOM 1718 C CA . GLY A 1 228 ? 32.346 63.226 46.779 1.00 29.06 ? 294 GLY A CA 1 ATOM 1719 C C . GLY A 1 228 ? 33.791 63.186 46.329 1.00 31.05 ? 294 GLY A C 1 ATOM 1720 O O . GLY A 1 228 ? 34.387 62.110 46.292 1.00 30.90 ? 294 GLY A O 1 ATOM 1721 N N . ALA A 1 229 ? 34.379 64.337 46.009 1.00 26.74 ? 295 ALA A N 1 ATOM 1722 C CA . ALA A 1 229 ? 35.786 64.419 45.626 1.00 26.35 ? 295 ALA A CA 1 ATOM 1723 C C . ALA A 1 229 ? 36.550 65.026 46.802 1.00 29.40 ? 295 ALA A C 1 ATOM 1724 O O . ALA A 1 229 ? 36.060 65.960 47.434 1.00 28.89 ? 295 ALA A O 1 ATOM 1725 C CB . ALA A 1 229 ? 35.932 65.282 44.386 1.00 27.38 ? 295 ALA A CB 1 ATOM 1726 N N . SER A 1 230 ? 37.704 64.465 47.146 1.00 28.15 ? 296 SER A N 1 ATOM 1727 C CA . SER A 1 230 ? 38.498 64.940 48.288 1.00 29.30 ? 296 SER A CA 1 ATOM 1728 C C . SER A 1 230 ? 39.184 66.254 48.015 1.00 35.62 ? 296 SER A C 1 ATOM 1729 O O . SER A 1 230 ? 39.286 67.112 48.894 1.00 35.98 ? 296 SER A O 1 ATOM 1730 C CB . SER A 1 230 ? 39.580 63.925 48.657 1.00 31.84 ? 296 SER A CB 1 ATOM 1731 O OG . SER A 1 230 ? 39.057 62.626 48.858 1.00 42.11 ? 296 SER A OG 1 ATOM 1732 N N . TYR A 1 231 ? 39.762 66.337 46.828 1.00 33.74 ? 297 TYR A N 1 ATOM 1733 C CA . TYR A 1 231 ? 40.621 67.425 46.440 1.00 35.03 ? 297 TYR A CA 1 ATOM 1734 C C . TYR A 1 231 ? 40.018 68.284 45.389 1.00 40.82 ? 297 TYR A C 1 ATOM 1735 O O . TYR A 1 231 ? 39.043 67.914 44.735 1.00 41.21 ? 297 TYR A O 1 ATOM 1736 C CB . TYR A 1 231 ? 41.960 66.842 45.897 1.00 36.85 ? 297 TYR A CB 1 ATOM 1737 C CG . TYR A 1 231 ? 42.785 66.035 46.881 1.00 39.96 ? 297 TYR A CG 1 ATOM 1738 C CD1 . TYR A 1 231 ? 42.519 66.080 48.248 1.00 40.67 ? 297 TYR A CD1 1 ATOM 1739 C CD2 . TYR A 1 231 ? 43.897 65.312 46.460 1.00 43.41 ? 297 TYR A CD2 1 ATOM 1740 C CE1 . TYR A 1 231 ? 43.286 65.364 49.160 1.00 40.69 ? 297 TYR A CE1 1 ATOM 1741 C CE2 . TYR A 1 231 ? 44.708 64.632 47.372 1.00 45.34 ? 297 TYR A CE2 1 ATOM 1742 C CZ . TYR A 1 231 ? 44.374 64.630 48.720 1.00 54.34 ? 297 TYR A CZ 1 ATOM 1743 O OH . TYR A 1 231 ? 45.128 63.933 49.639 1.00 58.99 ? 297 TYR A OH 1 ATOM 1744 N N . ILE A 1 232 ? 40.635 69.439 45.206 1.00 38.04 ? 298 ILE A N 1 ATOM 1745 C CA . ILE A 1 232 ? 40.333 70.303 44.095 1.00 38.25 ? 298 ILE A CA 1 ATOM 1746 C C . ILE A 1 232 ? 41.087 69.620 42.925 1.00 42.36 ? 298 ILE A C 1 ATOM 1747 O O . ILE A 1 232 ? 42.225 69.158 43.106 1.00 41.72 ? 298 ILE A O 1 ATOM 1748 C CB . ILE A 1 232 ? 40.836 71.748 44.373 1.00 40.76 ? 298 ILE A CB 1 ATOM 1749 C CG1 . ILE A 1 232 ? 39.846 72.472 45.336 1.00 40.51 ? 298 ILE A CG1 1 ATOM 1750 C CG2 . ILE A 1 232 ? 41.038 72.525 43.053 1.00 40.95 ? 298 ILE A CG2 1 ATOM 1751 C CD1 . ILE A 1 232 ? 40.207 73.923 45.739 1.00 44.28 ? 298 ILE A CD1 1 ATOM 1752 N N . SER A 1 233 ? 40.441 69.492 41.768 1.00 38.30 ? 299 SER A N 1 ATOM 1753 C CA . SER A 1 233 ? 41.118 68.901 40.620 1.00 37.64 ? 299 SER A CA 1 ATOM 1754 C C . SER A 1 233 ? 41.016 69.740 39.334 1.00 44.14 ? 299 SER A C 1 ATOM 1755 O O . SER A 1 233 ? 40.045 70.446 39.115 1.00 43.35 ? 299 SER A O 1 ATOM 1756 C CB . SER A 1 233 ? 40.660 67.472 40.385 1.00 37.29 ? 299 SER A CB 1 ATOM 1757 O OG . SER A 1 233 ? 39.502 67.445 39.577 1.00 41.33 ? 299 SER A OG 1 ATOM 1758 N N . GLY A 1 234 ? 42.042 69.642 38.511 1.00 43.78 ? 300 GLY A N 1 ATOM 1759 C CA . GLY A 1 234 ? 42.107 70.264 37.198 1.00 44.38 ? 300 GLY A CA 1 ATOM 1760 C C . GLY A 1 234 ? 42.625 69.236 36.214 1.00 49.16 ? 300 GLY A C 1 ATOM 1761 O O . GLY A 1 234 ? 42.957 68.107 36.606 1.00 46.78 ? 300 GLY A O 1 ATOM 1762 N N . SER A 1 235 ? 42.715 69.618 34.934 1.00 48.28 ? 301 SER A N 1 ATOM 1763 C CA . SER A 1 235 ? 43.279 68.754 33.889 1.00 48.63 ? 301 SER A CA 1 ATOM 1764 C C . SER A 1 235 ? 44.781 68.621 34.145 1.00 53.43 ? 301 SER A C 1 ATOM 1765 O O . SER A 1 235 ? 45.361 69.488 34.811 1.00 52.52 ? 301 SER A O 1 ATOM 1766 C CB . SER A 1 235 ? 43.051 69.374 32.515 1.00 51.75 ? 301 SER A CB 1 ATOM 1767 O OG . SER A 1 235 ? 43.684 70.642 32.419 1.00 55.85 ? 301 SER A OG 1 ATOM 1768 N N . THR A 1 236 ? 45.409 67.552 33.614 1.00 52.05 ? 302 THR A N 1 ATOM 1769 C CA . THR A 1 236 ? 46.855 67.297 33.761 1.00 51.89 ? 302 THR A CA 1 ATOM 1770 C C . THR A 1 236 ? 47.674 68.519 33.345 1.00 55.57 ? 302 THR A C 1 ATOM 1771 O O . THR A 1 236 ? 48.638 68.848 34.038 1.00 55.06 ? 302 THR A O 1 ATOM 1772 C CB . THR A 1 236 ? 47.271 66.024 33.000 1.00 58.92 ? 302 THR A CB 1 ATOM 1773 O OG1 . THR A 1 236 ? 46.459 64.935 33.430 1.00 59.78 ? 302 THR A OG1 1 ATOM 1774 C CG2 . THR A 1 236 ? 48.739 65.649 33.229 1.00 55.93 ? 302 THR A CG2 1 ATOM 1775 N N . SER A 1 237 ? 47.265 69.212 32.250 1.00 51.77 ? 303 SER A N 1 ATOM 1776 C CA . SER A 1 237 ? 47.982 70.395 31.764 1.00 52.01 ? 303 SER A CA 1 ATOM 1777 C C . SER A 1 237 ? 47.897 71.560 32.739 1.00 55.41 ? 303 SER A C 1 ATOM 1778 O O . SER A 1 237 ? 48.943 72.089 33.133 1.00 55.81 ? 303 SER A O 1 ATOM 1779 C CB . SER A 1 237 ? 47.546 70.787 30.350 1.00 55.23 ? 303 SER A CB 1 ATOM 1780 O OG . SER A 1 237 ? 46.152 71.010 30.231 1.00 65.28 ? 303 SER A OG 1 ATOM 1781 N N . SER A 1 238 ? 46.666 71.893 33.199 1.00 50.97 ? 304 SER A N 1 ATOM 1782 C CA . SER A 1 238 ? 46.422 72.971 34.173 1.00 49.90 ? 304 SER A CA 1 ATOM 1783 C C . SER A 1 238 ? 47.192 72.737 35.476 1.00 52.54 ? 304 SER A C 1 ATOM 1784 O O . SER A 1 238 ? 47.822 73.662 35.987 1.00 52.61 ? 304 SER A O 1 ATOM 1785 C CB . SER A 1 238 ? 44.932 73.105 34.475 1.00 52.60 ? 304 SER A CB 1 ATOM 1786 O OG . SER A 1 238 ? 44.167 73.224 33.290 1.00 62.55 ? 304 SER A OG 1 ATOM 1787 N N . ILE A 1 239 ? 47.170 71.494 35.986 1.00 48.06 ? 305 ILE A N 1 ATOM 1788 C CA . ILE A 1 239 ? 47.818 71.126 37.241 1.00 47.55 ? 305 ILE A CA 1 ATOM 1789 C C . ILE A 1 239 ? 49.338 71.169 37.095 1.00 53.93 ? 305 ILE A C 1 ATOM 1790 O O . ILE A 1 239 ? 50.005 71.592 38.042 1.00 53.47 ? 305 ILE A O 1 ATOM 1791 C CB . ILE A 1 239 ? 47.254 69.797 37.824 1.00 49.16 ? 305 ILE A CB 1 ATOM 1792 C CG1 . ILE A 1 239 ? 45.741 69.941 38.119 1.00 48.92 ? 305 ILE A CG1 1 ATOM 1793 C CG2 . ILE A 1 239 ? 47.999 69.311 39.071 1.00 47.38 ? 305 ILE A CG2 1 ATOM 1794 C CD1 . ILE A 1 239 ? 45.260 71.199 38.992 1.00 50.38 ? 305 ILE A CD1 1 ATOM 1795 N N . GLU A 1 240 ? 49.874 70.827 35.906 1.00 53.04 ? 306 GLU A N 1 ATOM 1796 C CA . GLU A 1 240 ? 51.312 70.931 35.641 1.00 53.81 ? 306 GLU A CA 1 ATOM 1797 C C . GLU A 1 240 ? 51.775 72.403 35.791 1.00 56.75 ? 306 GLU A C 1 ATOM 1798 O O . GLU A 1 240 ? 52.732 72.656 36.526 1.00 57.43 ? 306 GLU A O 1 ATOM 1799 C CB . GLU A 1 240 ? 51.686 70.342 34.267 1.00 55.65 ? 306 GLU A CB 1 ATOM 1800 C CG . GLU A 1 240 ? 51.961 68.844 34.318 1.00 69.94 ? 306 GLU A CG 1 ATOM 1801 C CD . GLU A 1 240 ? 51.891 68.052 33.015 1.00 99.38 ? 306 GLU A CD 1 ATOM 1802 O OE1 . GLU A 1 240 ? 51.631 68.651 31.944 1.00 93.12 ? 306 GLU A OE1 1 ATOM 1803 O OE2 . GLU A 1 240 ? 52.093 66.816 33.075 1.00 92.12 ? 306 GLU A OE2 1 ATOM 1804 N N . LYS A 1 241 ? 51.049 73.359 35.180 1.00 51.64 ? 307 LYS A N 1 ATOM 1805 C CA . LYS A 1 241 ? 51.369 74.790 35.281 1.00 52.57 ? 307 LYS A CA 1 ATOM 1806 C C . LYS A 1 241 ? 51.195 75.295 36.717 1.00 57.47 ? 307 LYS A C 1 ATOM 1807 O O . LYS A 1 241 ? 52.080 75.997 37.218 1.00 58.35 ? 307 LYS A O 1 ATOM 1808 C CB . LYS A 1 241 ? 50.523 75.636 34.312 1.00 55.63 ? 307 LYS A CB 1 ATOM 1809 C CG . LYS A 1 241 ? 50.742 75.316 32.839 1.00 73.02 ? 307 LYS A CG 1 ATOM 1810 C CD . LYS A 1 241 ? 49.737 76.043 31.943 1.00 85.96 ? 307 LYS A CD 1 ATOM 1811 C CE . LYS A 1 241 ? 50.045 75.878 30.465 1.00 102.55 ? 307 LYS A CE 1 ATOM 1812 N NZ . LYS A 1 241 ? 51.212 76.706 30.025 1.00 112.63 ? 307 LYS A NZ 1 ATOM 1813 N N . LEU A 1 242 ? 50.073 74.910 37.389 1.00 52.40 ? 308 LEU A N 1 ATOM 1814 C CA . LEU A 1 242 ? 49.772 75.286 38.773 1.00 50.84 ? 308 LEU A CA 1 ATOM 1815 C C . LEU A 1 242 ? 50.870 74.821 39.732 1.00 52.42 ? 308 LEU A C 1 ATOM 1816 O O . LEU A 1 242 ? 51.358 75.618 40.532 1.00 52.92 ? 308 LEU A O 1 ATOM 1817 C CB . LEU A 1 242 ? 48.388 74.758 39.209 1.00 50.89 ? 308 LEU A CB 1 ATOM 1818 C CG . LEU A 1 242 ? 48.000 74.995 40.684 1.00 55.35 ? 308 LEU A CG 1 ATOM 1819 C CD1 . LEU A 1 242 ? 46.759 75.812 40.807 1.00 55.34 ? 308 LEU A CD1 1 ATOM 1820 C CD2 . LEU A 1 242 ? 47.767 73.717 41.390 1.00 58.30 ? 308 LEU A CD2 1 ATOM 1821 N N . MET A 1 243 ? 51.279 73.556 39.631 1.00 45.82 ? 309 MET A N 1 ATOM 1822 C CA . MET A 1 243 ? 52.290 72.979 40.518 1.00 44.81 ? 309 MET A CA 1 ATOM 1823 C C . MET A 1 243 ? 53.705 73.517 40.296 1.00 52.79 ? 309 MET A C 1 ATOM 1824 O O . MET A 1 243 ? 54.491 73.585 41.246 1.00 51.50 ? 309 MET A O 1 ATOM 1825 C CB . MET A 1 243 ? 52.255 71.455 40.451 1.00 45.85 ? 309 MET A CB 1 ATOM 1826 C CG . MET A 1 243 ? 50.935 70.882 40.955 1.00 47.21 ? 309 MET A CG 1 ATOM 1827 S SD . MET A 1 243 ? 50.713 71.025 42.742 1.00 48.06 ? 309 MET A SD 1 ATOM 1828 C CE . MET A 1 243 ? 49.051 70.428 42.885 1.00 44.64 ? 309 MET A CE 1 ATOM 1829 N N . GLU A 1 244 ? 54.019 73.912 39.050 1.00 53.92 ? 310 GLU A N 1 ATOM 1830 C CA . GLU A 1 244 ? 55.294 74.527 38.674 1.00 55.10 ? 310 GLU A CA 1 ATOM 1831 C C . GLU A 1 244 ? 55.393 75.863 39.424 1.00 56.93 ? 310 GLU A C 1 ATOM 1832 O O . GLU A 1 244 ? 56.410 76.125 40.063 1.00 55.41 ? 310 GLU A O 1 ATOM 1833 C CB . GLU A 1 244 ? 55.340 74.754 37.153 1.00 57.40 ? 310 GLU A CB 1 ATOM 1834 C CG . GLU A 1 244 ? 56.694 75.211 36.623 1.00 74.39 ? 310 GLU A CG 1 ATOM 1835 C CD . GLU A 1 244 ? 56.742 75.475 35.133 1.00 111.11 ? 310 GLU A CD 1 ATOM 1836 O OE1 . GLU A 1 244 ? 55.689 75.780 34.522 1.00 104.64 ? 310 GLU A OE1 1 ATOM 1837 O OE2 . GLU A 1 244 ? 57.841 75.305 34.558 1.00 116.33 ? 310 GLU A OE2 1 ATOM 1838 N N . ALA A 1 245 ? 54.294 76.651 39.418 1.00 53.48 ? 311 ALA A N 1 ATOM 1839 C CA . ALA A 1 245 ? 54.166 77.935 40.115 1.00 52.97 ? 311 ALA A CA 1 ATOM 1840 C C . ALA A 1 245 ? 54.305 77.804 41.633 1.00 58.20 ? 311 ALA A C 1 ATOM 1841 O O . ALA A 1 245 ? 54.771 78.749 42.274 1.00 59.71 ? 311 ALA A O 1 ATOM 1842 C CB . ALA A 1 245 ? 52.844 78.596 39.760 1.00 53.31 ? 311 ALA A CB 1 ATOM 1843 N N . LEU A 1 246 ? 53.921 76.642 42.207 1.00 53.44 ? 312 LEU A N 1 ATOM 1844 C CA . LEU A 1 246 ? 54.024 76.377 43.646 1.00 52.35 ? 312 LEU A CA 1 ATOM 1845 C C . LEU A 1 246 ? 55.382 75.778 44.042 1.00 55.99 ? 312 LEU A C 1 ATOM 1846 O O . LEU A 1 246 ? 55.741 75.807 45.219 1.00 57.44 ? 312 LEU A O 1 ATOM 1847 C CB . LEU A 1 246 ? 52.874 75.464 44.136 1.00 52.08 ? 312 LEU A CB 1 ATOM 1848 C CG . LEU A 1 246 ? 51.426 75.923 43.884 1.00 55.83 ? 312 LEU A CG 1 ATOM 1849 C CD1 . LEU A 1 246 ? 50.448 74.797 44.121 1.00 55.05 ? 312 LEU A CD1 1 ATOM 1850 C CD2 . LEU A 1 246 ? 51.060 77.127 44.713 1.00 58.36 ? 312 LEU A CD2 1 ATOM 1851 N N . GLY A 1 247 ? 56.117 75.238 43.072 1.00 50.46 ? 313 GLY A N 1 ATOM 1852 C CA . GLY A 1 247 ? 57.406 74.601 43.315 1.00 49.13 ? 313 GLY A CA 1 ATOM 1853 C C . GLY A 1 247 ? 57.238 73.207 43.867 1.00 52.55 ? 313 GLY A C 1 ATOM 1854 O O . GLY A 1 247 ? 58.136 72.684 44.538 1.00 51.67 ? 313 GLY A O 1 ATOM 1855 N N . ALA A 1 248 ? 56.069 72.599 43.571 1.00 50.55 ? 314 ALA A N 1 ATOM 1856 C CA . ALA A 1 248 ? 55.668 71.258 43.995 1.00 50.25 ? 314 ALA A CA 1 ATOM 1857 C C . ALA A 1 248 ? 56.171 70.204 43.033 1.00 53.30 ? 314 ALA A C 1 ATOM 1858 O O . ALA A 1 248 ? 56.194 70.438 41.816 1.00 51.89 ? 314 ALA A O 1 ATOM 1859 C CB . ALA A 1 248 ? 54.154 71.164 44.112 1.00 50.99 ? 314 ALA A CB 1 ATOM 1860 N N . LYS A 1 249 ? 56.545 69.024 43.608 1.00 49.62 ? 315 LYS A N 1 ATOM 1861 C CA . LYS A 1 249 ? 57.052 67.821 42.944 1.00 49.13 ? 315 LYS A CA 1 ATOM 1862 C C . LYS A 1 249 ? 55.974 66.734 42.799 1.00 52.11 ? 315 LYS A C 1 ATOM 1863 O O . LYS A 1 249 ? 55.317 66.345 43.775 1.00 51.56 ? 315 LYS A O 1 ATOM 1864 C CB . LYS A 1 249 ? 58.269 67.270 43.693 1.00 49.68 ? 315 LYS A CB 1 ATOM 1865 N N . LYS A 1 250 ? 55.811 66.239 41.567 1.00 49.16 ? 316 LYS A N 1 ATOM 1866 C CA . LYS A 1 250 ? 54.857 65.191 41.224 1.00 49.03 ? 316 LYS A CA 1 ATOM 1867 C C . LYS A 1 250 ? 55.308 63.827 41.705 1.00 54.05 ? 316 LYS A C 1 ATOM 1868 O O . LYS A 1 250 ? 56.469 63.444 41.531 1.00 54.70 ? 316 LYS A O 1 ATOM 1869 C CB . LYS A 1 250 ? 54.602 65.148 39.709 1.00 51.81 ? 316 LYS A CB 1 ATOM 1870 C CG . LYS A 1 250 ? 53.339 64.363 39.331 1.00 65.89 ? 316 LYS A CG 1 ATOM 1871 C CD . LYS A 1 250 ? 53.304 63.964 37.864 1.00 74.97 ? 316 LYS A CD 1 ATOM 1872 C CE . LYS A 1 250 ? 53.754 62.530 37.642 1.00 86.45 ? 316 LYS A CE 1 ATOM 1873 N NZ . LYS A 1 250 ? 52.738 61.534 38.079 1.00 88.23 ? 316 LYS A NZ 1 ATOM 1874 N N . ARG A 1 251 ? 54.379 63.090 42.311 1.00 50.25 ? 317 ARG A N 1 ATOM 1875 C CA . ARG A 1 251 ? 54.604 61.715 42.733 1.00 49.46 ? 317 ARG A CA 1 ATOM 1876 C C . ARG A 1 251 ? 53.656 60.822 41.910 1.00 57.00 ? 317 ARG A C 1 ATOM 1877 O O . ARG A 1 251 ? 53.149 61.283 40.867 1.00 57.06 ? 317 ARG A O 1 ATOM 1878 C CB . ARG A 1 251 ? 54.423 61.552 44.239 1.00 45.13 ? 317 ARG A CB 1 ATOM 1879 C CG . ARG A 1 251 ? 55.590 62.130 45.028 1.00 49.76 ? 317 ARG A CG 1 ATOM 1880 C CD . ARG A 1 251 ? 55.664 61.597 46.442 1.00 54.90 ? 317 ARG A CD 1 ATOM 1881 N NE . ARG A 1 251 ? 54.378 61.697 47.140 1.00 63.68 ? 317 ARG A NE 1 ATOM 1882 C CZ . ARG A 1 251 ? 54.220 61.594 48.456 1.00 72.71 ? 317 ARG A CZ 1 ATOM 1883 N NH1 . ARG A 1 251 ? 55.274 61.445 49.248 1.00 52.04 ? 317 ARG A NH1 1 ATOM 1884 N NH2 . ARG A 1 251 ? 53.009 61.685 48.993 1.00 63.76 ? 317 ARG A NH2 1 ATOM 1885 N N . LEU A 1 252 ? 53.418 59.563 42.358 1.00 54.34 ? 318 LEU A N 1 ATOM 1886 C CA . LEU A 1 252 ? 52.551 58.609 41.657 1.00 53.99 ? 318 LEU A CA 1 ATOM 1887 C C . LEU A 1 252 ? 51.085 59.082 41.553 1.00 57.14 ? 318 LEU A C 1 ATOM 1888 O O . LEU A 1 252 ? 50.544 59.184 40.443 1.00 55.12 ? 318 LEU A O 1 ATOM 1889 C CB . LEU A 1 252 ? 52.672 57.230 42.343 1.00 54.01 ? 318 LEU A CB 1 ATOM 1890 C CG . LEU A 1 252 ? 52.074 55.954 41.700 1.00 57.89 ? 318 LEU A CG 1 ATOM 1891 C CD1 . LEU A 1 252 ? 52.451 55.786 40.260 1.00 57.50 ? 318 LEU A CD1 1 ATOM 1892 C CD2 . LEU A 1 252 ? 52.543 54.735 42.446 1.00 59.21 ? 318 LEU A CD2 1 ATOM 1893 N N . PHE A 1 253 ? 50.482 59.446 42.711 1.00 54.33 ? 319 PHE A N 1 ATOM 1894 C CA . PHE A 1 253 ? 49.083 59.863 42.792 1.00 53.80 ? 319 PHE A CA 1 ATOM 1895 C C . PHE A 1 253 ? 48.842 61.284 43.281 1.00 59.65 ? 319 PHE A C 1 ATOM 1896 O O . PHE A 1 253 ? 47.762 61.827 43.034 1.00 60.47 ? 319 PHE A O 1 ATOM 1897 C CB . PHE A 1 253 ? 48.300 58.866 43.655 1.00 54.49 ? 319 PHE A CB 1 ATOM 1898 C CG . PHE A 1 253 ? 48.349 57.477 43.068 1.00 54.58 ? 319 PHE A CG 1 ATOM 1899 C CD1 . PHE A 1 253 ? 47.822 57.218 41.802 1.00 55.98 ? 319 PHE A CD1 1 ATOM 1900 C CD2 . PHE A 1 253 ? 48.965 56.435 43.758 1.00 54.66 ? 319 PHE A CD2 1 ATOM 1901 C CE1 . PHE A 1 253 ? 47.902 55.940 41.243 1.00 56.21 ? 319 PHE A CE1 1 ATOM 1902 C CE2 . PHE A 1 253 ? 49.020 55.153 43.208 1.00 56.54 ? 319 PHE A CE2 1 ATOM 1903 C CZ . PHE A 1 253 ? 48.489 54.915 41.956 1.00 54.68 ? 319 PHE A CZ 1 ATOM 1904 N N . ASP A 1 254 ? 49.820 61.885 43.971 1.00 56.45 ? 320 ASP A N 1 ATOM 1905 C CA . ASP A 1 254 ? 49.672 63.248 44.491 1.00 55.52 ? 320 ASP A CA 1 ATOM 1906 C C . ASP A 1 254 ? 50.853 64.161 44.139 1.00 55.88 ? 320 ASP A C 1 ATOM 1907 O O . ASP A 1 254 ? 51.756 63.756 43.412 1.00 54.57 ? 320 ASP A O 1 ATOM 1908 C CB . ASP A 1 254 ? 49.389 63.233 46.016 1.00 57.17 ? 320 ASP A CB 1 ATOM 1909 C CG . ASP A 1 254 ? 50.415 62.558 46.920 1.00 66.88 ? 320 ASP A CG 1 ATOM 1910 O OD1 . ASP A 1 254 ? 51.626 62.644 46.622 1.00 66.40 ? 320 ASP A OD1 1 ATOM 1911 O OD2 . ASP A 1 254 ? 50.008 62.000 47.965 1.00 75.24 ? 320 ASP A OD2 1 ATOM 1912 N N . TYR A 1 255 ? 50.806 65.403 44.650 1.00 50.26 ? 321 TYR A N 1 ATOM 1913 C CA . TYR A 1 255 ? 51.813 66.441 44.558 1.00 48.80 ? 321 TYR A CA 1 ATOM 1914 C C . TYR A 1 255 ? 52.207 66.844 45.969 1.00 50.03 ? 321 TYR A C 1 ATOM 1915 O O . TYR A 1 255 ? 51.360 66.970 46.854 1.00 49.22 ? 321 TYR A O 1 ATOM 1916 C CB . TYR A 1 255 ? 51.267 67.652 43.831 1.00 49.75 ? 321 TYR A CB 1 ATOM 1917 C CG . TYR A 1 255 ? 51.346 67.537 42.333 1.00 51.15 ? 321 TYR A CG 1 ATOM 1918 C CD1 . TYR A 1 255 ? 52.478 67.958 41.642 1.00 52.62 ? 321 TYR A CD1 1 ATOM 1919 C CD2 . TYR A 1 255 ? 50.274 67.048 41.596 1.00 52.17 ? 321 TYR A CD2 1 ATOM 1920 C CE1 . TYR A 1 255 ? 52.538 67.900 40.251 1.00 53.38 ? 321 TYR A CE1 1 ATOM 1921 C CE2 . TYR A 1 255 ? 50.332 66.960 40.207 1.00 53.31 ? 321 TYR A CE2 1 ATOM 1922 C CZ . TYR A 1 255 ? 51.462 67.401 39.537 1.00 59.62 ? 321 TYR A CZ 1 ATOM 1923 O OH . TYR A 1 255 ? 51.518 67.322 38.167 1.00 59.43 ? 321 TYR A OH 1 ATOM 1924 N N . VAL A 1 256 ? 53.500 67.022 46.177 1.00 44.18 ? 322 VAL A N 1 ATOM 1925 C CA . VAL A 1 256 ? 54.071 67.381 47.464 1.00 42.58 ? 322 VAL A CA 1 ATOM 1926 C C . VAL A 1 256 ? 54.971 68.617 47.369 1.00 46.06 ? 322 VAL A C 1 ATOM 1927 O O . VAL A 1 256 ? 55.323 69.056 46.276 1.00 45.47 ? 322 VAL A O 1 ATOM 1928 C CB . VAL A 1 256 ? 54.801 66.189 48.144 1.00 45.09 ? 322 VAL A CB 1 ATOM 1929 C CG1 . VAL A 1 256 ? 53.833 65.076 48.494 1.00 43.90 ? 322 VAL A CG1 1 ATOM 1930 C CG2 . VAL A 1 256 ? 55.959 65.666 47.286 1.00 45.08 ? 322 VAL A CG2 1 ATOM 1931 N N . VAL A 1 257 ? 55.293 69.190 48.535 1.00 41.98 ? 323 VAL A N 1 ATOM 1932 C CA . VAL A 1 257 ? 56.219 70.290 48.790 1.00 40.61 ? 323 VAL A CA 1 ATOM 1933 C C . VAL A 1 257 ? 56.989 69.871 50.024 1.00 46.14 ? 323 VAL A C 1 ATOM 1934 O O . VAL A 1 257 ? 56.489 69.057 50.803 1.00 44.77 ? 323 VAL A O 1 ATOM 1935 C CB . VAL A 1 257 ? 55.564 71.699 48.977 1.00 43.34 ? 323 VAL A CB 1 ATOM 1936 C CG1 . VAL A 1 257 ? 55.063 72.261 47.661 1.00 42.71 ? 323 VAL A CG1 1 ATOM 1937 C CG2 . VAL A 1 257 ? 54.461 71.709 50.051 1.00 42.76 ? 323 VAL A CG2 1 ATOM 1938 N N . LYS A 1 258 ? 58.183 70.434 50.234 1.00 45.64 ? 324 LYS A N 1 ATOM 1939 C CA . LYS A 1 258 ? 58.943 70.197 51.465 1.00 46.46 ? 324 LYS A CA 1 ATOM 1940 C C . LYS A 1 258 ? 58.101 70.897 52.536 1.00 49.44 ? 324 LYS A C 1 ATOM 1941 O O . LYS A 1 258 ? 57.691 72.039 52.320 1.00 48.83 ? 324 LYS A O 1 ATOM 1942 C CB . LYS A 1 258 ? 60.324 70.861 51.370 1.00 50.63 ? 324 LYS A CB 1 ATOM 1943 C CG . LYS A 1 258 ? 61.308 70.147 50.455 1.00 75.06 ? 324 LYS A CG 1 ATOM 1944 C CD . LYS A 1 258 ? 62.720 70.273 50.990 1.00 95.17 ? 324 LYS A CD 1 ATOM 1945 C CE . LYS A 1 258 ? 63.718 69.598 50.089 1.00 114.88 ? 324 LYS A CE 1 ATOM 1946 N NZ . LYS A 1 258 ? 63.974 68.186 50.490 1.00 128.70 ? 324 LYS A NZ 1 ATOM 1947 N N . CYS A 1 259 ? 57.741 70.186 53.618 1.00 46.18 ? 325 CYS A N 1 ATOM 1948 C CA . CYS A 1 259 ? 56.868 70.700 54.684 1.00 45.19 ? 325 CYS A CA 1 ATOM 1949 C C . CYS A 1 259 ? 57.177 72.144 55.120 1.00 51.01 ? 325 CYS A C 1 ATOM 1950 O O . CYS A 1 259 ? 56.248 72.945 55.189 1.00 50.80 ? 325 CYS A O 1 ATOM 1951 C CB . CYS A 1 259 ? 56.835 69.752 55.877 1.00 44.44 ? 325 CYS A CB 1 ATOM 1952 S SG . CYS A 1 259 ? 55.936 68.213 55.567 1.00 48.01 ? 325 CYS A SG 1 ATOM 1953 N N . ASN A 1 260 ? 58.469 72.488 55.349 1.00 49.54 ? 326 ASN A N 1 ATOM 1954 C CA . ASN A 1 260 ? 58.921 73.819 55.782 1.00 49.74 ? 326 ASN A CA 1 ATOM 1955 C C . ASN A 1 260 ? 58.543 74.897 54.764 1.00 53.75 ? 326 ASN A C 1 ATOM 1956 O O . ASN A 1 260 ? 58.306 76.044 55.141 1.00 53.49 ? 326 ASN A O 1 ATOM 1957 C CB . ASN A 1 260 ? 60.434 73.818 56.024 1.00 51.22 ? 326 ASN A CB 1 ATOM 1958 C CG . ASN A 1 260 ? 61.266 73.580 54.787 1.00 68.35 ? 326 ASN A CG 1 ATOM 1959 O OD1 . ASN A 1 260 ? 61.180 72.538 54.129 1.00 61.64 ? 326 ASN A OD1 1 ATOM 1960 N ND2 . ASN A 1 260 ? 62.069 74.563 54.427 1.00 55.72 ? 326 ASN A ND2 1 ATOM 1961 N N . GLU A 1 261 ? 58.445 74.514 53.486 1.00 50.13 ? 327 GLU A N 1 ATOM 1962 C CA . GLU A 1 261 ? 58.092 75.437 52.418 1.00 50.23 ? 327 GLU A CA 1 ATOM 1963 C C . GLU A 1 261 ? 56.584 75.699 52.316 1.00 52.74 ? 327 GLU A C 1 ATOM 1964 O O . GLU A 1 261 ? 56.174 76.714 51.747 1.00 51.72 ? 327 GLU A O 1 ATOM 1965 C CB . GLU A 1 261 ? 58.687 74.962 51.092 1.00 51.95 ? 327 GLU A CB 1 ATOM 1966 C CG . GLU A 1 261 ? 60.131 75.399 50.933 1.00 68.22 ? 327 GLU A CG 1 ATOM 1967 C CD . GLU A 1 261 ? 60.948 74.636 49.911 1.00 105.63 ? 327 GLU A CD 1 ATOM 1968 O OE1 . GLU A 1 261 ? 62.145 74.384 50.184 1.00 110.03 ? 327 GLU A OE1 1 ATOM 1969 O OE2 . GLU A 1 261 ? 60.401 74.298 48.836 1.00 107.46 ? 327 GLU A OE2 1 ATOM 1970 N N . GLY A 1 262 ? 55.792 74.769 52.868 1.00 48.40 ? 328 GLY A N 1 ATOM 1971 C CA . GLY A 1 262 ? 54.329 74.794 52.873 1.00 48.47 ? 328 GLY A CA 1 ATOM 1972 C C . GLY A 1 262 ? 53.672 76.106 53.285 1.00 53.08 ? 328 GLY A C 1 ATOM 1973 O O . GLY A 1 262 ? 52.865 76.660 52.527 1.00 51.45 ? 328 GLY A O 1 ATOM 1974 N N . PRO A 1 263 ? 54.029 76.678 54.459 1.00 51.56 ? 329 PRO A N 1 ATOM 1975 C CA . PRO A 1 263 ? 53.391 77.940 54.875 1.00 51.71 ? 329 PRO A CA 1 ATOM 1976 C C . PRO A 1 263 ? 53.737 79.192 54.055 1.00 55.85 ? 329 PRO A C 1 ATOM 1977 O O . PRO A 1 263 ? 53.174 80.259 54.291 1.00 56.07 ? 329 PRO A O 1 ATOM 1978 C CB . PRO A 1 263 ? 53.860 78.090 56.320 1.00 53.41 ? 329 PRO A CB 1 ATOM 1979 C CG . PRO A 1 263 ? 54.355 76.730 56.743 1.00 57.90 ? 329 PRO A CG 1 ATOM 1980 C CD . PRO A 1 263 ? 54.941 76.178 55.513 1.00 53.22 ? 329 PRO A CD 1 ATOM 1981 N N . THR A 1 264 ? 54.635 79.061 53.090 1.00 52.30 ? 330 THR A N 1 ATOM 1982 C CA . THR A 1 264 ? 55.115 80.170 52.270 1.00 52.04 ? 330 THR A CA 1 ATOM 1983 C C . THR A 1 264 ? 54.414 80.247 50.913 1.00 54.12 ? 330 THR A C 1 ATOM 1984 O O . THR A 1 264 ? 54.475 81.292 50.271 1.00 54.83 ? 330 THR A O 1 ATOM 1985 C CB . THR A 1 264 ? 56.666 80.109 52.138 1.00 59.65 ? 330 THR A CB 1 ATOM 1986 O OG1 . THR A 1 264 ? 57.048 79.298 51.006 1.00 61.67 ? 330 THR A OG1 1 ATOM 1987 C CG2 . THR A 1 264 ? 57.364 79.630 53.436 1.00 51.67 ? 330 THR A CG2 1 ATOM 1988 N N . LEU A 1 265 ? 53.771 79.147 50.482 1.00 48.72 ? 331 LEU A N 1 ATOM 1989 C CA . LEU A 1 265 ? 53.075 79.002 49.203 1.00 48.49 ? 331 LEU A CA 1 ATOM 1990 C C . LEU A 1 265 ? 52.023 80.086 48.966 1.00 52.06 ? 331 LEU A C 1 ATOM 1991 O O . LEU A 1 265 ? 51.402 80.532 49.931 1.00 50.48 ? 331 LEU A O 1 ATOM 1992 C CB . LEU A 1 265 ? 52.471 77.583 49.040 1.00 48.90 ? 331 LEU A CB 1 ATOM 1993 C CG . LEU A 1 265 ? 53.388 76.337 49.205 1.00 53.45 ? 331 LEU A CG 1 ATOM 1994 C CD1 . LEU A 1 265 ? 52.665 75.088 48.755 1.00 53.74 ? 331 LEU A CD1 1 ATOM 1995 C CD2 . LEU A 1 265 ? 54.682 76.457 48.414 1.00 54.78 ? 331 LEU A CD2 1 ATOM 1996 N N . PRO A 1 266 ? 51.833 80.553 47.702 1.00 49.97 ? 332 PRO A N 1 ATOM 1997 C CA . PRO A 1 266 ? 50.874 81.652 47.455 1.00 49.26 ? 332 PRO A CA 1 ATOM 1998 C C . PRO A 1 266 ? 49.414 81.251 47.568 1.00 52.70 ? 332 PRO A C 1 ATOM 1999 O O . PRO A 1 266 ? 49.105 80.071 47.618 1.00 53.09 ? 332 PRO A O 1 ATOM 2000 C CB . PRO A 1 266 ? 51.217 82.100 46.020 1.00 50.65 ? 332 PRO A CB 1 ATOM 2001 C CG . PRO A 1 266 ? 51.740 80.874 45.371 1.00 54.87 ? 332 PRO A CG 1 ATOM 2002 C CD . PRO A 1 266 ? 52.511 80.142 46.448 1.00 50.66 ? 332 PRO A CD 1 ATOM 2003 N N . ASP A 1 267 ? 48.516 82.245 47.572 1.00 48.39 ? 333 ASP A N 1 ATOM 2004 C CA . ASP A 1 267 ? 47.073 82.036 47.613 1.00 46.99 ? 333 ASP A CA 1 ATOM 2005 C C . ASP A 1 267 ? 46.624 81.559 46.246 1.00 50.53 ? 333 ASP A C 1 ATOM 2006 O O . ASP A 1 267 ? 47.218 81.946 45.240 1.00 49.99 ? 333 ASP A O 1 ATOM 2007 C CB . ASP A 1 267 ? 46.345 83.361 47.925 1.00 47.76 ? 333 ASP A CB 1 ATOM 2008 C CG . ASP A 1 267 ? 46.542 83.948 49.311 1.00 50.57 ? 333 ASP A CG 1 ATOM 2009 O OD1 . ASP A 1 267 ? 47.144 83.271 50.169 1.00 51.61 ? 333 ASP A OD1 1 ATOM 2010 O OD2 . ASP A 1 267 ? 46.051 85.056 49.551 1.00 55.99 ? 333 ASP A OD2 1 ATOM 2011 N N . ILE A 1 268 ? 45.589 80.717 46.204 1.00 46.38 ? 334 ILE A N 1 ATOM 2012 C CA . ILE A 1 268 ? 44.995 80.270 44.950 1.00 45.14 ? 334 ILE A CA 1 ATOM 2013 C C . ILE A 1 268 ? 43.577 80.803 44.960 1.00 49.16 ? 334 ILE A C 1 ATOM 2014 O O . ILE A 1 268 ? 42.866 80.637 45.953 1.00 48.85 ? 334 ILE A O 1 ATOM 2015 C CB . ILE A 1 268 ? 45.108 78.743 44.652 1.00 47.94 ? 334 ILE A CB 1 ATOM 2016 C CG1 . ILE A 1 268 ? 46.590 78.284 44.754 1.00 47.56 ? 334 ILE A CG1 1 ATOM 2017 C CG2 . ILE A 1 268 ? 44.511 78.433 43.243 1.00 49.92 ? 334 ILE A CG2 1 ATOM 2018 C CD1 . ILE A 1 268 ? 46.843 76.851 44.756 1.00 49.54 ? 334 ILE A CD1 1 ATOM 2019 N N . SER A 1 269 ? 43.192 81.501 43.884 1.00 45.86 ? 335 SER A N 1 ATOM 2020 C CA . SER A 1 269 ? 41.886 82.141 43.771 1.00 45.36 ? 335 SER A CA 1 ATOM 2021 C C . SER A 1 269 ? 41.130 81.627 42.588 1.00 48.80 ? 335 SER A C 1 ATOM 2022 O O . SER A 1 269 ? 41.694 81.499 41.508 1.00 49.12 ? 335 SER A O 1 ATOM 2023 C CB . SER A 1 269 ? 42.034 83.658 43.688 1.00 49.61 ? 335 SER A CB 1 ATOM 2024 O OG . SER A 1 269 ? 42.606 84.160 44.883 1.00 61.71 ? 335 SER A OG 1 ATOM 2025 N N . PHE A 1 270 ? 39.840 81.339 42.794 1.00 44.50 ? 336 PHE A N 1 ATOM 2026 C CA . PHE A 1 270 ? 38.934 80.810 41.778 1.00 42.99 ? 336 PHE A CA 1 ATOM 2027 C C . PHE A 1 270 ? 37.862 81.857 41.545 1.00 48.68 ? 336 PHE A C 1 ATOM 2028 O O . PHE A 1 270 ? 37.147 82.225 42.479 1.00 48.24 ? 336 PHE A O 1 ATOM 2029 C CB . PHE A 1 270 ? 38.325 79.458 42.244 1.00 43.40 ? 336 PHE A CB 1 ATOM 2030 C CG . PHE A 1 270 ? 39.346 78.413 42.649 1.00 43.38 ? 336 PHE A CG 1 ATOM 2031 C CD1 . PHE A 1 270 ? 39.875 77.533 41.711 1.00 44.75 ? 336 PHE A CD1 1 ATOM 2032 C CD2 . PHE A 1 270 ? 39.784 78.317 43.967 1.00 44.05 ? 336 PHE A CD2 1 ATOM 2033 C CE1 . PHE A 1 270 ? 40.865 76.620 42.063 1.00 45.63 ? 336 PHE A CE1 1 ATOM 2034 C CE2 . PHE A 1 270 ? 40.762 77.385 44.326 1.00 46.48 ? 336 PHE A CE2 1 ATOM 2035 C CZ . PHE A 1 270 ? 41.295 76.538 43.367 1.00 44.50 ? 336 PHE A CZ 1 ATOM 2036 N N . HIS A 1 271 ? 37.791 82.381 40.321 1.00 47.33 ? 337 HIS A N 1 ATOM 2037 C CA . HIS A 1 271 ? 36.817 83.402 39.953 1.00 48.34 ? 337 HIS A CA 1 ATOM 2038 C C . HIS A 1 271 ? 35.509 82.724 39.526 1.00 46.66 ? 337 HIS A C 1 ATOM 2039 O O . HIS A 1 271 ? 35.431 82.110 38.462 1.00 44.92 ? 337 HIS A O 1 ATOM 2040 C CB . HIS A 1 271 ? 37.381 84.345 38.862 1.00 50.82 ? 337 HIS A CB 1 ATOM 2041 C CG . HIS A 1 271 ? 36.624 85.637 38.712 1.00 56.30 ? 337 HIS A CG 1 ATOM 2042 N ND1 . HIS A 1 271 ? 37.286 86.833 38.497 1.00 59.12 ? 337 HIS A ND1 1 ATOM 2043 C CD2 . HIS A 1 271 ? 35.285 85.875 38.730 1.00 59.35 ? 337 HIS A CD2 1 ATOM 2044 C CE1 . HIS A 1 271 ? 36.337 87.750 38.371 1.00 59.18 ? 337 HIS A CE1 1 ATOM 2045 N NE2 . HIS A 1 271 ? 35.117 87.222 38.518 1.00 59.65 ? 337 HIS A NE2 1 ATOM 2046 N N . LEU A 1 272 ? 34.511 82.786 40.400 1.00 41.54 ? 338 LEU A N 1 ATOM 2047 C CA . LEU A 1 272 ? 33.199 82.171 40.186 1.00 41.12 ? 338 LEU A CA 1 ATOM 2048 C C . LEU A 1 272 ? 32.130 83.245 40.304 1.00 47.53 ? 338 LEU A C 1 ATOM 2049 O O . LEU A 1 272 ? 32.051 83.915 41.338 1.00 47.59 ? 338 LEU A O 1 ATOM 2050 C CB . LEU A 1 272 ? 32.947 81.057 41.246 1.00 40.51 ? 338 LEU A CB 1 ATOM 2051 C CG . LEU A 1 272 ? 34.016 79.964 41.380 1.00 43.96 ? 338 LEU A CG 1 ATOM 2052 C CD1 . LEU A 1 272 ? 33.809 79.174 42.634 1.00 43.58 ? 338 LEU A CD1 1 ATOM 2053 C CD2 . LEU A 1 272 ? 34.043 79.046 40.154 1.00 44.24 ? 338 LEU A CD2 1 ATOM 2054 N N . GLY A 1 273 ? 31.312 83.398 39.262 1.00 46.15 ? 339 GLY A N 1 ATOM 2055 C CA . GLY A 1 273 ? 30.271 84.424 39.221 1.00 46.49 ? 339 GLY A CA 1 ATOM 2056 C C . GLY A 1 273 ? 30.890 85.795 39.448 1.00 52.03 ? 339 GLY A C 1 ATOM 2057 O O . GLY A 1 273 ? 31.960 86.100 38.907 1.00 51.64 ? 339 GLY A O 1 ATOM 2058 N N . GLY A 1 274 ? 30.296 86.569 40.343 1.00 50.16 ? 340 GLY A N 1 ATOM 2059 C CA . GLY A 1 274 ? 30.836 87.885 40.666 1.00 50.72 ? 340 GLY A CA 1 ATOM 2060 C C . GLY A 1 274 ? 31.973 87.938 41.676 1.00 56.39 ? 340 GLY A C 1 ATOM 2061 O O . GLY A 1 274 ? 32.603 88.994 41.805 1.00 58.33 ? 340 GLY A O 1 ATOM 2062 N N . LYS A 1 275 ? 32.263 86.818 42.407 1.00 50.66 ? 341 LYS A N 1 ATOM 2063 C CA . LYS A 1 275 ? 33.272 86.805 43.480 1.00 48.71 ? 341 LYS A CA 1 ATOM 2064 C C . LYS A 1 275 ? 34.534 85.974 43.220 1.00 50.03 ? 341 LYS A C 1 ATOM 2065 O O . LYS A 1 275 ? 34.516 85.042 42.415 1.00 51.27 ? 341 LYS A O 1 ATOM 2066 C CB . LYS A 1 275 ? 32.619 86.355 44.802 1.00 50.08 ? 341 LYS A CB 1 ATOM 2067 N N . GLU A 1 276 ? 35.640 86.345 43.893 1.00 43.58 ? 342 GLU A N 1 ATOM 2068 C CA . GLU A 1 276 ? 36.904 85.598 43.893 1.00 43.23 ? 342 GLU A CA 1 ATOM 2069 C C . GLU A 1 276 ? 36.906 84.752 45.177 1.00 44.88 ? 342 GLU A C 1 ATOM 2070 O O . GLU A 1 276 ? 36.654 85.277 46.266 1.00 43.26 ? 342 GLU A O 1 ATOM 2071 C CB . GLU A 1 276 ? 38.154 86.519 43.825 1.00 44.75 ? 342 GLU A CB 1 ATOM 2072 C CG . GLU A 1 276 ? 38.534 86.977 42.417 1.00 56.98 ? 342 GLU A CG 1 ATOM 2073 C CD . GLU A 1 276 ? 39.253 85.993 41.508 1.00 80.89 ? 342 GLU A CD 1 ATOM 2074 O OE1 . GLU A 1 276 ? 39.375 86.275 40.293 1.00 59.21 ? 342 GLU A OE1 1 ATOM 2075 O OE2 . GLU A 1 276 ? 39.719 84.949 42.015 1.00 84.57 ? 342 GLU A OE2 1 ATOM 2076 N N . TYR A 1 277 ? 37.117 83.439 45.026 1.00 40.70 ? 343 TYR A N 1 ATOM 2077 C CA . TYR A 1 277 ? 37.124 82.451 46.113 1.00 38.76 ? 343 TYR A CA 1 ATOM 2078 C C . TYR A 1 277 ? 38.565 82.026 46.347 1.00 41.72 ? 343 TYR A C 1 ATOM 2079 O O . TYR A 1 277 ? 39.154 81.316 45.534 1.00 40.66 ? 343 TYR A O 1 ATOM 2080 C CB . TYR A 1 277 ? 36.171 81.281 45.782 1.00 38.52 ? 343 TYR A CB 1 ATOM 2081 C CG . TYR A 1 277 ? 34.718 81.713 45.767 1.00 37.50 ? 343 TYR A CG 1 ATOM 2082 C CD1 . TYR A 1 277 ? 33.981 81.784 46.947 1.00 38.36 ? 343 TYR A CD1 1 ATOM 2083 C CD2 . TYR A 1 277 ? 34.116 82.172 44.595 1.00 38.41 ? 343 TYR A CD2 1 ATOM 2084 C CE1 . TYR A 1 277 ? 32.665 82.254 46.954 1.00 37.23 ? 343 TYR A CE1 1 ATOM 2085 C CE2 . TYR A 1 277 ? 32.792 82.624 44.586 1.00 39.07 ? 343 TYR A CE2 1 ATOM 2086 C CZ . TYR A 1 277 ? 32.073 82.667 45.773 1.00 44.11 ? 343 TYR A CZ 1 ATOM 2087 O OH . TYR A 1 277 ? 30.773 83.123 45.795 1.00 46.45 ? 343 TYR A OH 1 ATOM 2088 N N . THR A 1 278 ? 39.152 82.556 47.422 1.00 38.81 ? 344 THR A N 1 ATOM 2089 C CA . THR A 1 278 ? 40.558 82.407 47.748 1.00 38.26 ? 344 THR A CA 1 ATOM 2090 C C . THR A 1 278 ? 40.837 81.399 48.853 1.00 44.60 ? 344 THR A C 1 ATOM 2091 O O . THR A 1 278 ? 40.256 81.428 49.941 1.00 44.84 ? 344 THR A O 1 ATOM 2092 C CB . THR A 1 278 ? 41.177 83.800 48.053 1.00 40.30 ? 344 THR A CB 1 ATOM 2093 O OG1 . THR A 1 278 ? 40.920 84.659 46.933 1.00 37.78 ? 344 THR A OG1 1 ATOM 2094 C CG2 . THR A 1 278 ? 42.696 83.755 48.324 1.00 33.58 ? 344 THR A CG2 1 ATOM 2095 N N . LEU A 1 279 ? 41.818 80.551 48.560 1.00 41.69 ? 345 LEU A N 1 ATOM 2096 C CA . LEU A 1 279 ? 42.351 79.548 49.453 1.00 41.38 ? 345 LEU A CA 1 ATOM 2097 C C . LEU A 1 279 ? 43.816 79.908 49.727 1.00 45.29 ? 345 LEU A C 1 ATOM 2098 O O . LEU A 1 279 ? 44.580 80.140 48.793 1.00 45.59 ? 345 LEU A O 1 ATOM 2099 C CB . LEU A 1 279 ? 42.308 78.157 48.782 1.00 41.05 ? 345 LEU A CB 1 ATOM 2100 C CG . LEU A 1 279 ? 41.025 77.352 48.714 1.00 44.83 ? 345 LEU A CG 1 ATOM 2101 C CD1 . LEU A 1 279 ? 41.345 75.950 48.406 1.00 44.84 ? 345 LEU A CD1 1 ATOM 2102 C CD2 . LEU A 1 279 ? 40.152 77.451 49.911 1.00 47.81 ? 345 LEU A CD2 1 ATOM 2103 N N . THR A 1 280 ? 44.195 79.973 51.001 1.00 40.70 ? 346 THR A N 1 ATOM 2104 C CA . THR A 1 280 ? 45.577 80.231 51.408 1.00 39.83 ? 346 THR A CA 1 ATOM 2105 C C . THR A 1 280 ? 46.282 78.868 51.484 1.00 41.65 ? 346 THR A C 1 ATOM 2106 O O . THR A 1 280 ? 45.618 77.838 51.348 1.00 38.53 ? 346 THR A O 1 ATOM 2107 C CB . THR A 1 280 ? 45.642 81.006 52.747 1.00 48.14 ? 346 THR A CB 1 ATOM 2108 O OG1 . THR A 1 280 ? 45.257 80.167 53.837 1.00 47.25 ? 346 THR A OG1 1 ATOM 2109 C CG2 . THR A 1 280 ? 44.831 82.286 52.727 1.00 47.10 ? 346 THR A CG2 1 ATOM 2110 N N . SER A 1 281 ? 47.611 78.857 51.692 1.00 39.70 ? 347 SER A N 1 ATOM 2111 C CA . SER A 1 281 ? 48.378 77.617 51.799 1.00 40.68 ? 347 SER A CA 1 ATOM 2112 C C . SER A 1 281 ? 47.852 76.709 52.929 1.00 44.86 ? 347 SER A C 1 ATOM 2113 O O . SER A 1 281 ? 47.814 75.492 52.766 1.00 45.09 ? 347 SER A O 1 ATOM 2114 C CB . SER A 1 281 ? 49.859 77.902 51.970 1.00 45.03 ? 347 SER A CB 1 ATOM 2115 O OG . SER A 1 281 ? 50.072 78.693 53.130 1.00 57.09 ? 347 SER A OG 1 ATOM 2116 N N . ALA A 1 282 ? 47.360 77.301 54.019 1.00 40.58 ? 348 ALA A N 1 ATOM 2117 C CA . ALA A 1 282 ? 46.770 76.584 55.151 1.00 39.44 ? 348 ALA A CA 1 ATOM 2118 C C . ALA A 1 282 ? 45.519 75.808 54.728 1.00 40.26 ? 348 ALA A C 1 ATOM 2119 O O . ALA A 1 282 ? 45.210 74.788 55.341 1.00 41.27 ? 348 ALA A O 1 ATOM 2120 C CB . ALA A 1 282 ? 46.422 77.560 56.264 1.00 39.95 ? 348 ALA A CB 1 ATOM 2121 N N . ASP A 1 283 ? 44.842 76.265 53.665 1.00 33.87 ? 349 ASP A N 1 ATOM 2122 C CA . ASP A 1 283 ? 43.630 75.656 53.120 1.00 33.47 ? 349 ASP A CA 1 ATOM 2123 C C . ASP A 1 283 ? 43.892 74.507 52.160 1.00 39.67 ? 349 ASP A C 1 ATOM 2124 O O . ASP A 1 283 ? 43.037 73.642 52.036 1.00 40.20 ? 349 ASP A O 1 ATOM 2125 C CB . ASP A 1 283 ? 42.719 76.708 52.444 1.00 34.20 ? 349 ASP A CB 1 ATOM 2126 C CG . ASP A 1 283 ? 42.256 77.830 53.335 1.00 43.19 ? 349 ASP A CG 1 ATOM 2127 O OD1 . ASP A 1 283 ? 41.814 77.544 54.468 1.00 46.99 ? 349 ASP A OD1 1 ATOM 2128 O OD2 . ASP A 1 283 ? 42.272 78.986 52.880 1.00 45.91 ? 349 ASP A OD2 1 ATOM 2129 N N . TYR A 1 284 ? 45.049 74.481 51.477 1.00 37.88 ? 350 TYR A N 1 ATOM 2130 C CA . TYR A 1 284 ? 45.325 73.415 50.516 1.00 37.56 ? 350 TYR A CA 1 ATOM 2131 C C . TYR A 1 284 ? 46.567 72.570 50.849 1.00 41.11 ? 350 TYR A C 1 ATOM 2132 O O . TYR A 1 284 ? 46.820 71.606 50.146 1.00 40.73 ? 350 TYR A O 1 ATOM 2133 C CB . TYR A 1 284 ? 45.373 73.963 49.082 1.00 39.19 ? 350 TYR A CB 1 ATOM 2134 C CG . TYR A 1 284 ? 46.506 74.921 48.777 1.00 42.02 ? 350 TYR A CG 1 ATOM 2135 C CD1 . TYR A 1 284 ? 47.756 74.449 48.395 1.00 44.61 ? 350 TYR A CD1 1 ATOM 2136 C CD2 . TYR A 1 284 ? 46.288 76.293 48.720 1.00 42.86 ? 350 TYR A CD2 1 ATOM 2137 C CE1 . TYR A 1 284 ? 48.789 75.318 48.064 1.00 44.80 ? 350 TYR A CE1 1 ATOM 2138 C CE2 . TYR A 1 284 ? 47.314 77.173 48.387 1.00 43.71 ? 350 TYR A CE2 1 ATOM 2139 C CZ . TYR A 1 284 ? 48.559 76.676 48.046 1.00 49.80 ? 350 TYR A CZ 1 ATOM 2140 O OH . TYR A 1 284 ? 49.589 77.505 47.711 1.00 47.29 ? 350 TYR A OH 1 ATOM 2141 N N . VAL A 1 285 ? 47.313 72.888 51.916 1.00 37.99 ? 351 VAL A N 1 ATOM 2142 C CA . VAL A 1 285 ? 48.504 72.094 52.266 1.00 37.38 ? 351 VAL A CA 1 ATOM 2143 C C . VAL A 1 285 ? 48.179 71.257 53.472 1.00 42.08 ? 351 VAL A C 1 ATOM 2144 O O . VAL A 1 285 ? 47.714 71.791 54.473 1.00 41.57 ? 351 VAL A O 1 ATOM 2145 C CB . VAL A 1 285 ? 49.829 72.920 52.488 1.00 39.56 ? 351 VAL A CB 1 ATOM 2146 C CG1 . VAL A 1 285 ? 51.019 72.006 52.805 1.00 38.90 ? 351 VAL A CG1 1 ATOM 2147 C CG2 . VAL A 1 285 ? 50.154 73.791 51.283 1.00 39.07 ? 351 VAL A CG2 1 ATOM 2148 N N . PHE A 1 286 ? 48.458 69.951 53.404 1.00 39.79 ? 352 PHE A N 1 ATOM 2149 C CA . PHE A 1 286 ? 48.285 69.074 54.565 1.00 39.55 ? 352 PHE A CA 1 ATOM 2150 C C . PHE A 1 286 ? 49.544 69.243 55.402 1.00 42.11 ? 352 PHE A C 1 ATOM 2151 O O . PHE A 1 286 ? 50.526 68.509 55.242 1.00 40.17 ? 352 PHE A O 1 ATOM 2152 C CB . PHE A 1 286 ? 48.017 67.609 54.153 1.00 41.94 ? 352 PHE A CB 1 ATOM 2153 C CG . PHE A 1 286 ? 46.642 67.357 53.553 1.00 45.01 ? 352 PHE A CG 1 ATOM 2154 C CD1 . PHE A 1 286 ? 45.501 67.424 54.340 1.00 50.23 ? 352 PHE A CD1 1 ATOM 2155 C CD2 . PHE A 1 286 ? 46.495 67.012 52.213 1.00 47.71 ? 352 PHE A CD2 1 ATOM 2156 C CE1 . PHE A 1 286 ? 44.236 67.203 53.787 1.00 51.78 ? 352 PHE A CE1 1 ATOM 2157 C CE2 . PHE A 1 286 ? 45.230 66.769 51.669 1.00 51.94 ? 352 PHE A CE2 1 ATOM 2158 C CZ . PHE A 1 286 ? 44.111 66.858 52.461 1.00 50.38 ? 352 PHE A CZ 1 ATOM 2159 N N . GLN A 1 287 ? 49.537 70.301 56.232 1.00 40.52 ? 353 GLN A N 1 ATOM 2160 C CA . GLN A 1 287 ? 50.658 70.696 57.086 1.00 42.18 ? 353 GLN A CA 1 ATOM 2161 C C . GLN A 1 287 ? 50.842 69.724 58.254 1.00 54.76 ? 353 GLN A C 1 ATOM 2162 O O . GLN A 1 287 ? 50.518 70.056 59.398 1.00 55.40 ? 353 GLN A O 1 ATOM 2163 C CB . GLN A 1 287 ? 50.475 72.150 57.556 1.00 42.49 ? 353 GLN A CB 1 ATOM 2164 C CG . GLN A 1 287 ? 51.772 72.856 57.905 1.00 41.93 ? 353 GLN A CG 1 ATOM 2165 C CD . GLN A 1 287 ? 52.672 73.075 56.702 1.00 52.09 ? 353 GLN A CD 1 ATOM 2166 O OE1 . GLN A 1 287 ? 52.276 73.615 55.657 1.00 42.02 ? 353 GLN A OE1 1 ATOM 2167 N NE2 . GLN A 1 287 ? 53.912 72.662 56.837 1.00 32.73 ? 353 GLN A NE2 1 ATOM 2168 N N . GLU A 1 288 ? 51.365 68.510 57.957 1.00 56.21 ? 354 GLU A N 1 ATOM 2169 C CA . GLU A 1 288 ? 51.539 67.453 58.962 1.00 57.87 ? 354 GLU A CA 1 ATOM 2170 C C . GLU A 1 288 ? 52.734 67.718 59.875 1.00 63.35 ? 354 GLU A C 1 ATOM 2171 O O . GLU A 1 288 ? 52.773 67.206 61.007 1.00 65.08 ? 354 GLU A O 1 ATOM 2172 C CB . GLU A 1 288 ? 51.559 66.031 58.340 1.00 59.87 ? 354 GLU A CB 1 ATOM 2173 C CG . GLU A 1 288 ? 52.720 65.693 57.406 1.00 77.09 ? 354 GLU A CG 1 ATOM 2174 C CD . GLU A 1 288 ? 52.611 64.377 56.647 1.00 104.29 ? 354 GLU A CD 1 ATOM 2175 O OE1 . GLU A 1 288 ? 52.181 63.364 57.249 1.00 108.20 ? 354 GLU A OE1 1 ATOM 2176 O OE2 . GLU A 1 288 ? 53.004 64.348 55.458 1.00 93.06 ? 354 GLU A OE2 1 ATOM 2177 N N . SER A 1 289 ? 53.680 68.547 59.398 1.00 58.19 ? 355 SER A N 1 ATOM 2178 C CA . SER A 1 289 ? 54.893 69.008 60.095 1.00 57.06 ? 355 SER A CA 1 ATOM 2179 C C . SER A 1 289 ? 55.420 70.243 59.367 1.00 60.95 ? 355 SER A C 1 ATOM 2180 O O . SER A 1 289 ? 54.818 70.651 58.382 1.00 60.67 ? 355 SER A O 1 ATOM 2181 C CB . SER A 1 289 ? 55.959 67.907 60.156 1.00 59.77 ? 355 SER A CB 1 ATOM 2182 O OG . SER A 1 289 ? 56.856 67.892 59.055 1.00 67.69 ? 355 SER A OG 1 ATOM 2183 N N . TYR A 1 290 ? 56.520 70.835 59.852 1.00 59.36 ? 356 TYR A N 1 ATOM 2184 C CA . TYR A 1 290 ? 57.190 72.000 59.254 1.00 59.93 ? 356 TYR A CA 1 ATOM 2185 C C . TYR A 1 290 ? 58.653 71.653 58.985 1.00 64.67 ? 356 TYR A C 1 ATOM 2186 O O . TYR A 1 290 ? 59.499 72.540 58.806 1.00 64.58 ? 356 TYR A O 1 ATOM 2187 C CB . TYR A 1 290 ? 57.161 73.202 60.208 1.00 61.25 ? 356 TYR A CB 1 ATOM 2188 C CG . TYR A 1 290 ? 55.792 73.720 60.557 1.00 63.23 ? 356 TYR A CG 1 ATOM 2189 C CD1 . TYR A 1 290 ? 55.071 74.503 59.659 1.00 65.04 ? 356 TYR A CD1 1 ATOM 2190 C CD2 . TYR A 1 290 ? 55.244 73.496 61.816 1.00 64.24 ? 356 TYR A CD2 1 ATOM 2191 C CE1 . TYR A 1 290 ? 53.813 75.004 59.988 1.00 66.03 ? 356 TYR A CE1 1 ATOM 2192 C CE2 . TYR A 1 290 ? 53.997 74.007 62.162 1.00 65.37 ? 356 TYR A CE2 1 ATOM 2193 C CZ . TYR A 1 290 ? 53.278 74.747 61.240 1.00 75.11 ? 356 TYR A CZ 1 ATOM 2194 O OH . TYR A 1 290 ? 52.040 75.230 61.585 1.00 81.48 ? 356 TYR A OH 1 ATOM 2195 N N . SER A 1 291 ? 58.952 70.366 59.007 1.00 61.57 ? 357 SER A N 1 ATOM 2196 C CA . SER A 1 291 ? 60.289 69.852 58.816 1.00 61.74 ? 357 SER A CA 1 ATOM 2197 C C . SER A 1 291 ? 60.798 70.015 57.393 1.00 63.80 ? 357 SER A C 1 ATOM 2198 O O . SER A 1 291 ? 60.090 69.697 56.443 1.00 63.56 ? 357 SER A O 1 ATOM 2199 C CB . SER A 1 291 ? 60.334 68.384 59.222 1.00 67.08 ? 357 SER A CB 1 ATOM 2200 O OG . SER A 1 291 ? 61.633 67.849 59.022 1.00 79.82 ? 357 SER A OG 1 ATOM 2201 N N . SER A 1 292 ? 62.057 70.464 57.262 1.00 59.73 ? 358 SER A N 1 ATOM 2202 C CA . SER A 1 292 ? 62.785 70.578 55.995 1.00 59.25 ? 358 SER A CA 1 ATOM 2203 C C . SER A 1 292 ? 63.167 69.166 55.478 1.00 60.73 ? 358 SER A C 1 ATOM 2204 O O . SER A 1 292 ? 63.496 69.008 54.309 1.00 58.82 ? 358 SER A O 1 ATOM 2205 C CB . SER A 1 292 ? 64.028 71.456 56.164 1.00 64.44 ? 358 SER A CB 1 ATOM 2206 O OG . SER A 1 292 ? 64.727 71.207 57.375 1.00 76.64 ? 358 SER A OG 1 ATOM 2207 N N . LYS A 1 293 ? 63.074 68.146 56.377 1.00 57.64 ? 359 LYS A N 1 ATOM 2208 C CA . LYS A 1 293 ? 63.372 66.719 56.182 1.00 57.36 ? 359 LYS A CA 1 ATOM 2209 C C . LYS A 1 293 ? 62.108 65.871 55.878 1.00 59.29 ? 359 LYS A C 1 ATOM 2210 O O . LYS A 1 293 ? 62.175 64.630 55.878 1.00 58.38 ? 359 LYS A O 1 ATOM 2211 C CB . LYS A 1 293 ? 64.070 66.168 57.444 1.00 60.28 ? 359 LYS A CB 1 ATOM 2212 N N . LYS A 1 294 ? 60.953 66.538 55.653 1.00 53.23 ? 360 LYS A N 1 ATOM 2213 C CA . LYS A 1 294 ? 59.693 65.851 55.375 1.00 51.34 ? 360 LYS A CA 1 ATOM 2214 C C . LYS A 1 294 ? 58.928 66.472 54.214 1.00 51.99 ? 360 LYS A C 1 ATOM 2215 O O . LYS A 1 294 ? 59.069 67.662 53.932 1.00 51.72 ? 360 LYS A O 1 ATOM 2216 C CB . LYS A 1 294 ? 58.835 65.748 56.647 1.00 53.76 ? 360 LYS A CB 1 ATOM 2217 N N . LEU A 1 295 ? 58.146 65.645 53.509 1.00 47.17 ? 361 LEU A N 1 ATOM 2218 C CA . LEU A 1 295 ? 57.325 66.072 52.367 1.00 45.40 ? 361 LEU A CA 1 ATOM 2219 C C . LEU A 1 295 ? 55.861 66.161 52.788 1.00 47.68 ? 361 LEU A C 1 ATOM 2220 O O . LEU A 1 295 ? 55.359 65.285 53.491 1.00 46.76 ? 361 LEU A O 1 ATOM 2221 C CB . LEU A 1 295 ? 57.471 65.127 51.165 1.00 44.35 ? 361 LEU A CB 1 ATOM 2222 C CG . LEU A 1 295 ? 58.846 65.008 50.530 1.00 46.86 ? 361 LEU A CG 1 ATOM 2223 C CD1 . LEU A 1 295 ? 58.862 63.860 49.527 1.00 45.69 ? 361 LEU A CD1 1 ATOM 2224 C CD2 . LEU A 1 295 ? 59.284 66.322 49.904 1.00 46.33 ? 361 LEU A CD2 1 ATOM 2225 N N . CYS A 1 296 ? 55.191 67.240 52.375 1.00 43.15 ? 362 CYS A N 1 ATOM 2226 C CA . CYS A 1 296 ? 53.801 67.517 52.711 1.00 42.34 ? 362 CYS A CA 1 ATOM 2227 C C . CYS A 1 296 ? 52.935 67.503 51.469 1.00 43.76 ? 362 CYS A C 1 ATOM 2228 O O . CYS A 1 296 ? 53.271 68.154 50.479 1.00 43.06 ? 362 CYS A O 1 ATOM 2229 C CB . CYS A 1 296 ? 53.695 68.843 53.460 1.00 43.10 ? 362 CYS A CB 1 ATOM 2230 S SG . CYS A 1 296 ? 53.996 68.715 55.236 1.00 47.63 ? 362 CYS A SG 1 ATOM 2231 N N . THR A 1 297 ? 51.834 66.738 51.505 1.00 39.44 ? 363 THR A N 1 ATOM 2232 C CA . THR A 1 297 ? 50.901 66.601 50.385 1.00 38.97 ? 363 THR A CA 1 ATOM 2233 C C . THR A 1 297 ? 50.010 67.853 50.245 1.00 41.73 ? 363 THR A C 1 ATOM 2234 O O . THR A 1 297 ? 49.757 68.569 51.214 1.00 40.08 ? 363 THR A O 1 ATOM 2235 C CB . THR A 1 297 ? 50.049 65.307 50.555 1.00 50.23 ? 363 THR A CB 1 ATOM 2236 O OG1 . THR A 1 297 ? 50.860 64.175 50.881 1.00 57.61 ? 363 THR A OG1 1 ATOM 2237 C CG2 . THR A 1 297 ? 49.152 64.993 49.344 1.00 45.65 ? 363 THR A CG2 1 ATOM 2238 N N . LEU A 1 298 ? 49.529 68.077 49.025 1.00 38.68 ? 364 LEU A N 1 ATOM 2239 C CA . LEU A 1 298 ? 48.619 69.142 48.664 1.00 38.53 ? 364 LEU A CA 1 ATOM 2240 C C . LEU A 1 298 ? 47.227 68.564 48.413 1.00 40.87 ? 364 LEU A C 1 ATOM 2241 O O . LEU A 1 298 ? 47.096 67.469 47.865 1.00 39.90 ? 364 LEU A O 1 ATOM 2242 C CB . LEU A 1 298 ? 49.117 69.918 47.414 1.00 38.82 ? 364 LEU A CB 1 ATOM 2243 C CG . LEU A 1 298 ? 50.543 70.493 47.433 1.00 44.12 ? 364 LEU A CG 1 ATOM 2244 C CD1 . LEU A 1 298 ? 50.737 71.455 46.317 1.00 45.09 ? 364 LEU A CD1 1 ATOM 2245 C CD2 . LEU A 1 298 ? 50.863 71.245 48.743 1.00 42.94 ? 364 LEU A CD2 1 ATOM 2246 N N . ALA A 1 299 ? 46.191 69.340 48.733 1.00 36.97 ? 365 ALA A N 1 ATOM 2247 C CA . ALA A 1 299 ? 44.823 68.897 48.538 1.00 37.12 ? 365 ALA A CA 1 ATOM 2248 C C . ALA A 1 299 ? 44.298 69.335 47.155 1.00 39.49 ? 365 ALA A C 1 ATOM 2249 O O . ALA A 1 299 ? 43.141 69.726 46.989 1.00 37.29 ? 365 ALA A O 1 ATOM 2250 C CB . ALA A 1 299 ? 43.950 69.390 49.676 1.00 37.91 ? 365 ALA A CB 1 ATOM 2251 N N . ILE A 1 300 ? 45.201 69.253 46.161 1.00 37.22 ? 366 ILE A N 1 ATOM 2252 C CA . ILE A 1 300 ? 45.012 69.586 44.741 1.00 35.96 ? 366 ILE A CA 1 ATOM 2253 C C . ILE A 1 300 ? 45.733 68.516 43.925 1.00 40.70 ? 366 ILE A C 1 ATOM 2254 O O . ILE A 1 300 ? 46.884 68.196 44.215 1.00 39.19 ? 366 ILE A O 1 ATOM 2255 C CB . ILE A 1 300 ? 45.503 71.014 44.354 1.00 37.61 ? 366 ILE A CB 1 ATOM 2256 C CG1 . ILE A 1 300 ? 44.986 72.100 45.311 1.00 37.12 ? 366 ILE A CG1 1 ATOM 2257 C CG2 . ILE A 1 300 ? 45.123 71.350 42.909 1.00 37.77 ? 366 ILE A CG2 1 ATOM 2258 C CD1 . ILE A 1 300 ? 45.907 73.305 45.442 1.00 42.31 ? 366 ILE A CD1 1 ATOM 2259 N N . HIS A 1 301 ? 45.057 67.969 42.910 1.00 40.49 ? 367 HIS A N 1 ATOM 2260 C CA . HIS A 1 301 ? 45.627 66.954 42.017 1.00 42.04 ? 367 HIS A CA 1 ATOM 2261 C C . HIS A 1 301 ? 45.103 67.095 40.595 1.00 46.48 ? 367 HIS A C 1 ATOM 2262 O O . HIS A 1 301 ? 44.280 67.970 40.310 1.00 45.53 ? 367 HIS A O 1 ATOM 2263 C CB . HIS A 1 301 ? 45.409 65.521 42.569 1.00 43.79 ? 367 HIS A CB 1 ATOM 2264 C CG . HIS A 1 301 ? 43.992 65.031 42.576 1.00 48.19 ? 367 HIS A CG 1 ATOM 2265 N ND1 . HIS A 1 301 ? 43.704 63.676 42.543 1.00 50.54 ? 367 HIS A ND1 1 ATOM 2266 C CD2 . HIS A 1 301 ? 42.824 65.717 42.662 1.00 50.74 ? 367 HIS A CD2 1 ATOM 2267 C CE1 . HIS A 1 301 ? 42.384 63.582 42.620 1.00 49.79 ? 367 HIS A CE1 1 ATOM 2268 N NE2 . HIS A 1 301 ? 41.811 64.782 42.666 1.00 50.36 ? 367 HIS A NE2 1 ATOM 2269 N N . ALA A 1 302 ? 45.591 66.248 39.696 1.00 44.75 ? 368 ALA A N 1 ATOM 2270 C CA . ALA A 1 302 ? 45.121 66.266 38.318 1.00 44.51 ? 368 ALA A CA 1 ATOM 2271 C C . ALA A 1 302 ? 44.117 65.155 38.158 1.00 45.20 ? 368 ALA A C 1 ATOM 2272 O O . ALA A 1 302 ? 44.280 64.083 38.740 1.00 43.53 ? 368 ALA A O 1 ATOM 2273 C CB . ALA A 1 302 ? 46.282 66.072 37.354 1.00 45.34 ? 368 ALA A CB 1 ATOM 2274 N N . MET A 1 303 ? 43.077 65.404 37.384 1.00 43.16 ? 369 MET A N 1 ATOM 2275 C CA . MET A 1 303 ? 42.019 64.447 37.114 1.00 44.30 ? 369 MET A CA 1 ATOM 2276 C C . MET A 1 303 ? 41.444 64.858 35.769 1.00 49.75 ? 369 MET A C 1 ATOM 2277 O O . MET A 1 303 ? 40.878 65.943 35.652 1.00 48.98 ? 369 MET A O 1 ATOM 2278 C CB . MET A 1 303 ? 40.971 64.508 38.255 1.00 47.51 ? 369 MET A CB 1 ATOM 2279 C CG . MET A 1 303 ? 40.004 63.334 38.348 1.00 52.57 ? 369 MET A CG 1 ATOM 2280 S SD . MET A 1 303 ? 40.616 61.673 38.830 1.00 58.87 ? 369 MET A SD 1 ATOM 2281 C CE . MET A 1 303 ? 41.936 62.051 39.891 1.00 55.41 ? 369 MET A CE 1 ATOM 2282 N N . ASP A 1 304 ? 41.671 64.044 34.720 1.00 48.87 ? 370 ASP A N 1 ATOM 2283 C CA . ASP A 1 304 ? 41.136 64.343 33.394 1.00 49.46 ? 370 ASP A CA 1 ATOM 2284 C C . ASP A 1 304 ? 39.758 63.740 33.296 1.00 55.34 ? 370 ASP A C 1 ATOM 2285 O O . ASP A 1 304 ? 39.615 62.528 33.136 1.00 54.74 ? 370 ASP A O 1 ATOM 2286 C CB . ASP A 1 304 ? 42.064 63.868 32.255 1.00 50.58 ? 370 ASP A CB 1 ATOM 2287 C CG . ASP A 1 304 ? 43.446 64.489 32.284 1.00 52.88 ? 370 ASP A CG 1 ATOM 2288 O OD1 . ASP A 1 304 ? 43.542 65.742 32.377 1.00 49.78 ? 370 ASP A OD1 1 ATOM 2289 O OD2 . ASP A 1 304 ? 44.428 63.732 32.201 1.00 57.70 ? 370 ASP A OD2 1 ATOM 2290 N N . ILE A 1 305 ? 38.741 64.586 33.468 1.00 54.75 ? 371 ILE A N 1 ATOM 2291 C CA . ILE A 1 305 ? 37.352 64.145 33.416 1.00 55.51 ? 371 ILE A CA 1 ATOM 2292 C C . ILE A 1 305 ? 36.911 64.088 31.959 1.00 60.96 ? 371 ILE A C 1 ATOM 2293 O O . ILE A 1 305 ? 37.112 65.070 31.242 1.00 61.18 ? 371 ILE A O 1 ATOM 2294 C CB . ILE A 1 305 ? 36.443 64.968 34.362 1.00 58.43 ? 371 ILE A CB 1 ATOM 2295 C CG1 . ILE A 1 305 ? 36.887 64.755 35.828 1.00 58.27 ? 371 ILE A CG1 1 ATOM 2296 C CG2 . ILE A 1 305 ? 34.965 64.597 34.177 1.00 58.86 ? 371 ILE A CG2 1 ATOM 2297 C CD1 . ILE A 1 305 ? 36.740 65.907 36.753 1.00 62.33 ? 371 ILE A CD1 1 ATOM 2298 N N . PRO A 1 306 ? 36.421 62.916 31.474 1.00 58.82 ? 372 PRO A N 1 ATOM 2299 C CA . PRO A 1 306 ? 36.073 62.806 30.046 1.00 59.05 ? 372 PRO A CA 1 ATOM 2300 C C . PRO A 1 306 ? 34.773 63.505 29.662 1.00 63.70 ? 372 PRO A C 1 ATOM 2301 O O . PRO A 1 306 ? 33.935 63.713 30.532 1.00 63.84 ? 372 PRO A O 1 ATOM 2302 C CB . PRO A 1 306 ? 35.982 61.289 29.830 1.00 60.71 ? 372 PRO A CB 1 ATOM 2303 C CG . PRO A 1 306 ? 35.532 60.760 31.138 1.00 65.00 ? 372 PRO A CG 1 ATOM 2304 C CD . PRO A 1 306 ? 36.173 61.641 32.186 1.00 60.64 ? 372 PRO A CD 1 ATOM 2305 N N . PRO A 1 307 ? 34.541 63.813 28.362 1.00 60.83 ? 373 PRO A N 1 ATOM 2306 C CA . PRO A 1 307 ? 33.256 64.418 27.968 1.00 60.31 ? 373 PRO A CA 1 ATOM 2307 C C . PRO A 1 307 ? 32.055 63.488 28.223 1.00 63.34 ? 373 PRO A C 1 ATOM 2308 O O . PRO A 1 307 ? 32.259 62.289 28.432 1.00 62.81 ? 373 PRO A O 1 ATOM 2309 C CB . PRO A 1 307 ? 33.451 64.735 26.474 1.00 62.10 ? 373 PRO A CB 1 ATOM 2310 C CG . PRO A 1 307 ? 34.933 64.713 26.255 1.00 66.89 ? 373 PRO A CG 1 ATOM 2311 C CD . PRO A 1 307 ? 35.422 63.645 27.188 1.00 62.65 ? 373 PRO A CD 1 ATOM 2312 N N . PRO A 1 308 ? 30.801 63.996 28.295 1.00 59.83 ? 374 PRO A N 1 ATOM 2313 C CA . PRO A 1 308 ? 30.364 65.394 28.105 1.00 59.22 ? 374 PRO A CA 1 ATOM 2314 C C . PRO A 1 308 ? 30.638 66.328 29.304 1.00 61.17 ? 374 PRO A C 1 ATOM 2315 O O . PRO A 1 308 ? 30.755 67.533 29.085 1.00 61.71 ? 374 PRO A O 1 ATOM 2316 C CB . PRO A 1 308 ? 28.878 65.242 27.764 1.00 60.66 ? 374 PRO A CB 1 ATOM 2317 C CG . PRO A 1 308 ? 28.452 64.028 28.524 1.00 65.11 ? 374 PRO A CG 1 ATOM 2318 C CD . PRO A 1 308 ? 29.652 63.107 28.556 1.00 60.93 ? 374 PRO A CD 1 ATOM 2319 N N . THR A 1 309 ? 30.770 65.782 30.539 1.00 55.65 ? 375 THR A N 1 ATOM 2320 C CA . THR A 1 309 ? 31.033 66.531 31.784 1.00 54.49 ? 375 THR A CA 1 ATOM 2321 C C . THR A 1 309 ? 32.366 67.283 31.738 1.00 57.96 ? 375 THR A C 1 ATOM 2322 O O . THR A 1 309 ? 32.412 68.480 32.033 1.00 57.41 ? 375 THR A O 1 ATOM 2323 C CB . THR A 1 309 ? 30.919 65.607 33.010 1.00 59.98 ? 375 THR A CB 1 ATOM 2324 O OG1 . THR A 1 309 ? 29.636 64.987 33.005 1.00 58.69 ? 375 THR A OG1 1 ATOM 2325 C CG2 . THR A 1 309 ? 31.149 66.340 34.354 1.00 58.58 ? 375 THR A CG2 1 ATOM 2326 N N . GLY A 1 310 ? 33.423 66.581 31.354 1.00 54.09 ? 376 GLY A N 1 ATOM 2327 C CA . GLY A 1 310 ? 34.755 67.154 31.241 1.00 53.33 ? 376 GLY A CA 1 ATOM 2328 C C . GLY A 1 310 ? 35.099 67.554 29.818 1.00 56.42 ? 376 GLY A C 1 ATOM 2329 O O . GLY A 1 310 ? 34.308 67.303 28.905 1.00 56.45 ? 376 GLY A O 1 ATOM 2330 N N . PRO A 1 311 ? 36.270 68.175 29.563 1.00 51.61 ? 377 PRO A N 1 ATOM 2331 C CA . PRO A 1 311 ? 37.310 68.597 30.517 1.00 51.14 ? 377 PRO A CA 1 ATOM 2332 C C . PRO A 1 311 ? 36.745 69.644 31.479 1.00 53.01 ? 377 PRO A C 1 ATOM 2333 O O . PRO A 1 311 ? 36.005 70.547 31.062 1.00 52.53 ? 377 PRO A O 1 ATOM 2334 C CB . PRO A 1 311 ? 38.412 69.176 29.609 1.00 52.74 ? 377 PRO A CB 1 ATOM 2335 C CG . PRO A 1 311 ? 38.126 68.629 28.247 1.00 57.29 ? 377 PRO A CG 1 ATOM 2336 C CD . PRO A 1 311 ? 36.634 68.563 28.192 1.00 52.91 ? 377 PRO A CD 1 ATOM 2337 N N . THR A 1 312 ? 37.054 69.484 32.778 1.00 46.54 ? 378 THR A N 1 ATOM 2338 C CA . THR A 1 312 ? 36.560 70.369 33.830 1.00 44.73 ? 378 THR A CA 1 ATOM 2339 C C . THR A 1 312 ? 37.414 70.364 35.074 1.00 47.44 ? 378 THR A C 1 ATOM 2340 O O . THR A 1 312 ? 38.097 69.372 35.367 1.00 45.90 ? 378 THR A O 1 ATOM 2341 C CB . THR A 1 312 ? 35.107 69.984 34.197 1.00 49.23 ? 378 THR A CB 1 ATOM 2342 O OG1 . THR A 1 312 ? 34.570 70.952 35.091 1.00 49.02 ? 378 THR A OG1 1 ATOM 2343 C CG2 . THR A 1 312 ? 34.975 68.578 34.809 1.00 47.15 ? 378 THR A CG2 1 ATOM 2344 N N . TRP A 1 313 ? 37.351 71.464 35.833 1.00 43.52 ? 379 TRP A N 1 ATOM 2345 C CA . TRP A 1 313 ? 37.947 71.477 37.158 1.00 43.14 ? 379 TRP A CA 1 ATOM 2346 C C . TRP A 1 313 ? 36.882 70.855 38.088 1.00 40.53 ? 379 TRP A C 1 ATOM 2347 O O . TRP A 1 313 ? 35.695 70.849 37.758 1.00 37.86 ? 379 TRP A O 1 ATOM 2348 C CB . TRP A 1 313 ? 38.223 72.901 37.634 1.00 42.80 ? 379 TRP A CB 1 ATOM 2349 C CG . TRP A 1 313 ? 39.354 73.574 36.939 1.00 44.65 ? 379 TRP A CG 1 ATOM 2350 C CD1 . TRP A 1 313 ? 39.340 74.114 35.686 1.00 47.70 ? 379 TRP A CD1 1 ATOM 2351 C CD2 . TRP A 1 313 ? 40.620 73.916 37.511 1.00 44.84 ? 379 TRP A CD2 1 ATOM 2352 N NE1 . TRP A 1 313 ? 40.535 74.737 35.428 1.00 47.59 ? 379 TRP A NE1 1 ATOM 2353 C CE2 . TRP A 1 313 ? 41.347 74.620 36.527 1.00 48.96 ? 379 TRP A CE2 1 ATOM 2354 C CE3 . TRP A 1 313 ? 41.229 73.658 38.752 1.00 46.45 ? 379 TRP A CE3 1 ATOM 2355 C CZ2 . TRP A 1 313 ? 42.649 75.071 36.743 1.00 48.14 ? 379 TRP A CZ2 1 ATOM 2356 C CZ3 . TRP A 1 313 ? 42.518 74.110 38.969 1.00 48.32 ? 379 TRP A CZ3 1 ATOM 2357 C CH2 . TRP A 1 313 ? 43.209 74.820 37.978 1.00 49.12 ? 379 TRP A CH2 1 ATOM 2358 N N . ALA A 1 314 ? 37.302 70.337 39.230 1.00 34.54 ? 380 ALA A N 1 ATOM 2359 C CA . ALA A 1 314 ? 36.360 69.839 40.220 1.00 32.33 ? 380 ALA A CA 1 ATOM 2360 C C . ALA A 1 314 ? 36.696 70.494 41.558 1.00 33.49 ? 380 ALA A C 1 ATOM 2361 O O . ALA A 1 314 ? 37.858 70.508 41.963 1.00 31.15 ? 380 ALA A O 1 ATOM 2362 C CB . ALA A 1 314 ? 36.419 68.331 40.314 1.00 32.08 ? 380 ALA A CB 1 ATOM 2363 N N . LEU A 1 315 ? 35.694 71.114 42.193 1.00 30.24 ? 381 LEU A N 1 ATOM 2364 C CA . LEU A 1 315 ? 35.848 71.752 43.505 1.00 29.52 ? 381 LEU A CA 1 ATOM 2365 C C . LEU A 1 315 ? 35.304 70.793 44.546 1.00 34.15 ? 381 LEU A C 1 ATOM 2366 O O . LEU A 1 315 ? 34.091 70.680 44.715 1.00 32.98 ? 381 LEU A O 1 ATOM 2367 C CB . LEU A 1 315 ? 35.160 73.136 43.546 1.00 29.09 ? 381 LEU A CB 1 ATOM 2368 C CG . LEU A 1 315 ? 35.657 74.172 42.505 1.00 32.30 ? 381 LEU A CG 1 ATOM 2369 C CD1 . LEU A 1 315 ? 34.737 75.399 42.474 1.00 32.37 ? 381 LEU A CD1 1 ATOM 2370 C CD2 . LEU A 1 315 ? 37.123 74.541 42.739 1.00 28.28 ? 381 LEU A CD2 1 ATOM 2371 N N . GLY A 1 316 ? 36.219 70.020 45.135 1.00 31.38 ? 382 GLY A N 1 ATOM 2372 C CA . GLY A 1 316 ? 35.925 69.007 46.139 1.00 30.20 ? 382 GLY A CA 1 ATOM 2373 C C . GLY A 1 316 ? 36.005 69.496 47.566 1.00 34.40 ? 382 GLY A C 1 ATOM 2374 O O . GLY A 1 316 ? 35.926 70.700 47.805 1.00 35.85 ? 382 GLY A O 1 ATOM 2375 N N . ALA A 1 317 ? 36.192 68.567 48.529 1.00 31.03 ? 383 ALA A N 1 ATOM 2376 C CA . ALA A 1 317 ? 36.233 68.866 49.972 1.00 31.26 ? 383 ALA A CA 1 ATOM 2377 C C . ALA A 1 317 ? 37.186 70.011 50.341 1.00 36.42 ? 383 ALA A C 1 ATOM 2378 O O . ALA A 1 317 ? 36.844 70.800 51.221 1.00 35.51 ? 383 ALA A O 1 ATOM 2379 C CB . ALA A 1 317 ? 36.533 67.620 50.792 1.00 31.63 ? 383 ALA A CB 1 ATOM 2380 N N . THR A 1 318 ? 38.332 70.164 49.609 1.00 34.04 ? 384 THR A N 1 ATOM 2381 C CA . THR A 1 318 ? 39.306 71.257 49.834 1.00 33.32 ? 384 THR A CA 1 ATOM 2382 C C . THR A 1 318 ? 38.617 72.630 49.750 1.00 36.40 ? 384 THR A C 1 ATOM 2383 O O . THR A 1 318 ? 38.895 73.524 50.566 1.00 35.82 ? 384 THR A O 1 ATOM 2384 C CB . THR A 1 318 ? 40.474 71.175 48.828 1.00 39.43 ? 384 THR A CB 1 ATOM 2385 O OG1 . THR A 1 318 ? 40.995 69.849 48.805 1.00 39.16 ? 384 THR A OG1 1 ATOM 2386 C CG2 . THR A 1 318 ? 41.598 72.188 49.132 1.00 32.70 ? 384 THR A CG2 1 ATOM 2387 N N . PHE A 1 319 ? 37.719 72.774 48.754 1.00 31.79 ? 385 PHE A N 1 ATOM 2388 C CA . PHE A 1 319 ? 36.967 73.983 48.507 1.00 30.99 ? 385 PHE A CA 1 ATOM 2389 C C . PHE A 1 319 ? 35.791 74.160 49.485 1.00 34.14 ? 385 PHE A C 1 ATOM 2390 O O . PHE A 1 319 ? 35.678 75.215 50.089 1.00 32.24 ? 385 PHE A O 1 ATOM 2391 C CB . PHE A 1 319 ? 36.524 74.061 47.032 1.00 32.41 ? 385 PHE A CB 1 ATOM 2392 C CG . PHE A 1 319 ? 35.995 75.420 46.638 1.00 32.71 ? 385 PHE A CG 1 ATOM 2393 C CD1 . PHE A 1 319 ? 36.858 76.415 46.208 1.00 34.37 ? 385 PHE A CD1 1 ATOM 2394 C CD2 . PHE A 1 319 ? 34.632 75.708 46.712 1.00 33.62 ? 385 PHE A CD2 1 ATOM 2395 C CE1 . PHE A 1 319 ? 36.370 77.660 45.827 1.00 34.74 ? 385 PHE A CE1 1 ATOM 2396 C CE2 . PHE A 1 319 ? 34.151 76.970 46.353 1.00 36.22 ? 385 PHE A CE2 1 ATOM 2397 C CZ . PHE A 1 319 ? 35.021 77.926 45.893 1.00 33.33 ? 385 PHE A CZ 1 ATOM 2398 N N . ILE A 1 320 ? 34.936 73.131 49.637 1.00 33.21 ? 386 ILE A N 1 ATOM 2399 C CA . ILE A 1 320 ? 33.758 73.114 50.525 1.00 31.88 ? 386 ILE A CA 1 ATOM 2400 C C . ILE A 1 320 ? 34.113 73.390 52.001 1.00 34.11 ? 386 ILE A C 1 ATOM 2401 O O . ILE A 1 320 ? 33.304 74.015 52.692 1.00 33.22 ? 386 ILE A O 1 ATOM 2402 C CB . ILE A 1 320 ? 32.947 71.807 50.334 1.00 34.18 ? 386 ILE A CB 1 ATOM 2403 C CG1 . ILE A 1 320 ? 32.476 71.692 48.847 1.00 35.20 ? 386 ILE A CG1 1 ATOM 2404 C CG2 . ILE A 1 320 ? 31.757 71.733 51.301 1.00 30.81 ? 386 ILE A CG2 1 ATOM 2405 C CD1 . ILE A 1 320 ? 32.305 70.294 48.320 1.00 43.97 ? 386 ILE A CD1 1 ATOM 2406 N N . ARG A 1 321 ? 35.309 72.982 52.476 1.00 29.03 ? 387 ARG A N 1 ATOM 2407 C CA . ARG A 1 321 ? 35.721 73.262 53.867 1.00 28.61 ? 387 ARG A CA 1 ATOM 2408 C C . ARG A 1 321 ? 35.743 74.772 54.126 1.00 34.50 ? 387 ARG A C 1 ATOM 2409 O O . ARG A 1 321 ? 35.296 75.227 55.189 1.00 34.00 ? 387 ARG A O 1 ATOM 2410 C CB . ARG A 1 321 ? 37.110 72.681 54.168 1.00 25.18 ? 387 ARG A CB 1 ATOM 2411 C CG . ARG A 1 321 ? 37.068 71.274 54.649 1.00 30.29 ? 387 ARG A CG 1 ATOM 2412 C CD . ARG A 1 321 ? 38.398 70.816 55.229 1.00 36.48 ? 387 ARG A CD 1 ATOM 2413 N NE . ARG A 1 321 ? 39.470 70.645 54.239 1.00 35.69 ? 387 ARG A NE 1 ATOM 2414 C CZ . ARG A 1 321 ? 39.638 69.579 53.456 1.00 46.00 ? 387 ARG A CZ 1 ATOM 2415 N NH1 . ARG A 1 321 ? 38.761 68.586 53.475 1.00 38.91 ? 387 ARG A NH1 1 ATOM 2416 N NH2 . ARG A 1 321 ? 40.660 69.522 52.612 1.00 31.19 ? 387 ARG A NH2 1 ATOM 2417 N N . LYS A 1 322 ? 36.248 75.538 53.135 1.00 32.38 ? 388 LYS A N 1 ATOM 2418 C CA . LYS A 1 322 ? 36.362 76.984 53.224 1.00 33.79 ? 388 LYS A CA 1 ATOM 2419 C C . LYS A 1 322 ? 35.005 77.668 52.969 1.00 34.77 ? 388 LYS A C 1 ATOM 2420 O O . LYS A 1 322 ? 34.660 78.637 53.651 1.00 33.28 ? 388 LYS A O 1 ATOM 2421 C CB . LYS A 1 322 ? 37.452 77.474 52.246 1.00 38.74 ? 388 LYS A CB 1 ATOM 2422 C CG . LYS A 1 322 ? 37.706 78.993 52.264 1.00 40.80 ? 388 LYS A CG 1 ATOM 2423 C CD . LYS A 1 322 ? 38.786 79.388 53.165 1.00 46.26 ? 388 LYS A CD 1 ATOM 2424 C CE . LYS A 1 322 ? 39.097 80.858 52.993 1.00 43.86 ? 388 LYS A CE 1 ATOM 2425 N NZ . LYS A 1 322 ? 40.377 81.212 53.674 1.00 66.35 ? 388 LYS A NZ 1 ATOM 2426 N N . PHE A 1 323 ? 34.238 77.134 52.004 1.00 28.96 ? 389 PHE A N 1 ATOM 2427 C CA . PHE A 1 323 ? 32.963 77.685 51.564 1.00 26.89 ? 389 PHE A CA 1 ATOM 2428 C C . PHE A 1 323 ? 31.784 76.755 51.719 1.00 32.67 ? 389 PHE A C 1 ATOM 2429 O O . PHE A 1 323 ? 31.637 75.784 50.969 1.00 32.96 ? 389 PHE A O 1 ATOM 2430 C CB . PHE A 1 323 ? 33.067 78.187 50.116 1.00 27.86 ? 389 PHE A CB 1 ATOM 2431 C CG . PHE A 1 323 ? 34.160 79.229 49.952 1.00 29.78 ? 389 PHE A CG 1 ATOM 2432 C CD1 . PHE A 1 323 ? 34.019 80.503 50.495 1.00 31.32 ? 389 PHE A CD1 1 ATOM 2433 C CD2 . PHE A 1 323 ? 35.365 78.909 49.318 1.00 32.15 ? 389 PHE A CD2 1 ATOM 2434 C CE1 . PHE A 1 323 ? 35.074 81.440 50.407 1.00 32.19 ? 389 PHE A CE1 1 ATOM 2435 C CE2 . PHE A 1 323 ? 36.400 79.859 49.187 1.00 34.70 ? 389 PHE A CE2 1 ATOM 2436 C CZ . PHE A 1 323 ? 36.253 81.108 49.742 1.00 32.61 ? 389 PHE A CZ 1 ATOM 2437 N N . TYR A 1 324 ? 30.911 77.086 52.675 1.00 30.12 ? 390 TYR A N 1 ATOM 2438 C CA . TYR A 1 324 ? 29.633 76.406 52.911 1.00 30.38 ? 390 TYR A CA 1 ATOM 2439 C C . TYR A 1 324 ? 28.896 76.450 51.559 1.00 36.93 ? 390 TYR A C 1 ATOM 2440 O O . TYR A 1 324 ? 28.898 77.497 50.907 1.00 38.16 ? 390 TYR A O 1 ATOM 2441 C CB . TYR A 1 324 ? 28.842 77.157 54.001 1.00 29.98 ? 390 TYR A CB 1 ATOM 2442 C CG . TYR A 1 324 ? 27.591 76.430 54.427 1.00 29.92 ? 390 TYR A CG 1 ATOM 2443 C CD1 . TYR A 1 324 ? 26.382 76.618 53.752 1.00 31.65 ? 390 TYR A CD1 1 ATOM 2444 C CD2 . TYR A 1 324 ? 27.608 75.541 55.494 1.00 29.74 ? 390 TYR A CD2 1 ATOM 2445 C CE1 . TYR A 1 324 ? 25.230 75.921 54.120 1.00 29.65 ? 390 TYR A CE1 1 ATOM 2446 C CE2 . TYR A 1 324 ? 26.454 74.863 55.890 1.00 29.69 ? 390 TYR A CE2 1 ATOM 2447 C CZ . TYR A 1 324 ? 25.279 75.032 55.179 1.00 33.47 ? 390 TYR A CZ 1 ATOM 2448 O OH . TYR A 1 324 ? 24.166 74.337 55.553 1.00 34.46 ? 390 TYR A OH 1 ATOM 2449 N N . THR A 1 325 ? 28.353 75.311 51.104 1.00 33.59 ? 391 THR A N 1 ATOM 2450 C CA . THR A 1 325 ? 27.734 75.194 49.776 1.00 32.90 ? 391 THR A CA 1 ATOM 2451 C C . THR A 1 325 ? 26.259 74.791 49.805 1.00 37.31 ? 391 THR A C 1 ATOM 2452 O O . THR A 1 325 ? 25.887 73.818 50.451 1.00 37.14 ? 391 THR A O 1 ATOM 2453 C CB . THR A 1 325 ? 28.569 74.223 48.910 1.00 30.37 ? 391 THR A CB 1 ATOM 2454 O OG1 . THR A 1 325 ? 29.935 74.636 48.948 1.00 27.18 ? 391 THR A OG1 1 ATOM 2455 C CG2 . THR A 1 325 ? 28.083 74.147 47.476 1.00 25.68 ? 391 THR A CG2 1 ATOM 2456 N N . GLU A 1 326 ? 25.439 75.524 49.052 1.00 34.01 ? 392 GLU A N 1 ATOM 2457 C CA . GLU A 1 326 ? 24.015 75.263 48.901 1.00 33.14 ? 392 GLU A CA 1 ATOM 2458 C C . GLU A 1 326 ? 23.736 74.883 47.453 1.00 38.56 ? 392 GLU A C 1 ATOM 2459 O O . GLU A 1 326 ? 24.081 75.631 46.540 1.00 38.85 ? 392 GLU A O 1 ATOM 2460 C CB . GLU A 1 326 ? 23.192 76.495 49.317 1.00 33.79 ? 392 GLU A CB 1 ATOM 2461 C CG . GLU A 1 326 ? 21.718 76.301 49.068 1.00 36.40 ? 392 GLU A CG 1 ATOM 2462 C CD . GLU A 1 326 ? 20.882 77.474 49.504 1.00 62.74 ? 392 GLU A CD 1 ATOM 2463 O OE1 . GLU A 1 326 ? 20.840 78.487 48.772 1.00 60.74 ? 392 GLU A OE1 1 ATOM 2464 O OE2 . GLU A 1 326 ? 20.177 77.326 50.525 1.00 61.68 ? 392 GLU A OE2 1 ATOM 2465 N N . PHE A 1 327 ? 23.132 73.717 47.245 1.00 35.38 ? 393 PHE A N 1 ATOM 2466 C CA . PHE A 1 327 ? 22.793 73.221 45.916 1.00 34.12 ? 393 PHE A CA 1 ATOM 2467 C C . PHE A 1 327 ? 21.305 73.469 45.726 1.00 39.15 ? 393 PHE A C 1 ATOM 2468 O O . PHE A 1 327 ? 20.476 72.852 46.397 1.00 36.50 ? 393 PHE A O 1 ATOM 2469 C CB . PHE A 1 327 ? 23.147 71.723 45.797 1.00 34.34 ? 393 PHE A CB 1 ATOM 2470 C CG . PHE A 1 327 ? 24.624 71.453 45.928 1.00 32.57 ? 393 PHE A CG 1 ATOM 2471 C CD1 . PHE A 1 327 ? 25.458 71.499 44.813 1.00 33.20 ? 393 PHE A CD1 1 ATOM 2472 C CD2 . PHE A 1 327 ? 25.186 71.168 47.167 1.00 31.87 ? 393 PHE A CD2 1 ATOM 2473 C CE1 . PHE A 1 327 ? 26.834 71.272 44.936 1.00 34.37 ? 393 PHE A CE1 1 ATOM 2474 C CE2 . PHE A 1 327 ? 26.559 70.942 47.295 1.00 34.26 ? 393 PHE A CE2 1 ATOM 2475 C CZ . PHE A 1 327 ? 27.380 71.002 46.179 1.00 32.70 ? 393 PHE A CZ 1 ATOM 2476 N N . ASP A 1 328 ? 20.978 74.431 44.854 1.00 37.90 ? 394 ASP A N 1 ATOM 2477 C CA . ASP A 1 328 ? 19.616 74.885 44.624 1.00 38.12 ? 394 ASP A CA 1 ATOM 2478 C C . ASP A 1 328 ? 18.995 74.287 43.362 1.00 41.74 ? 394 ASP A C 1 ATOM 2479 O O . ASP A 1 328 ? 19.315 74.704 42.252 1.00 40.53 ? 394 ASP A O 1 ATOM 2480 C CB . ASP A 1 328 ? 19.613 76.426 44.611 1.00 39.50 ? 394 ASP A CB 1 ATOM 2481 C CG . ASP A 1 328 ? 18.263 77.107 44.602 1.00 47.46 ? 394 ASP A CG 1 ATOM 2482 O OD1 . ASP A 1 328 ? 17.238 76.408 44.363 1.00 49.19 ? 394 ASP A OD1 1 ATOM 2483 O OD2 . ASP A 1 328 ? 18.227 78.338 44.826 1.00 52.25 ? 394 ASP A OD2 1 ATOM 2484 N N . ARG A 1 329 ? 18.093 73.318 43.545 1.00 39.48 ? 395 ARG A N 1 ATOM 2485 C CA . ARG A 1 329 ? 17.430 72.623 42.436 1.00 40.54 ? 395 ARG A CA 1 ATOM 2486 C C . ARG A 1 329 ? 16.335 73.474 41.779 1.00 48.71 ? 395 ARG A C 1 ATOM 2487 O O . ARG A 1 329 ? 16.215 73.473 40.556 1.00 48.62 ? 395 ARG A O 1 ATOM 2488 C CB . ARG A 1 329 ? 16.855 71.269 42.898 1.00 38.72 ? 395 ARG A CB 1 ATOM 2489 C CG . ARG A 1 329 ? 17.874 70.165 43.145 1.00 40.37 ? 395 ARG A CG 1 ATOM 2490 C CD . ARG A 1 329 ? 18.274 69.504 41.842 1.00 57.19 ? 395 ARG A CD 1 ATOM 2491 N NE . ARG A 1 329 ? 17.117 69.017 41.077 1.00 65.69 ? 395 ARG A NE 1 ATOM 2492 C CZ . ARG A 1 329 ? 16.646 67.773 41.125 1.00 74.25 ? 395 ARG A CZ 1 ATOM 2493 N NH1 . ARG A 1 329 ? 17.247 66.856 41.872 1.00 52.89 ? 395 ARG A NH1 1 ATOM 2494 N NH2 . ARG A 1 329 ? 15.589 67.430 40.404 1.00 63.97 ? 395 ARG A NH2 1 ATOM 2495 N N . ARG A 1 330 ? 15.544 74.201 42.590 1.00 46.86 ? 396 ARG A N 1 ATOM 2496 C CA . ARG A 1 330 ? 14.468 75.062 42.108 1.00 46.88 ? 396 ARG A CA 1 ATOM 2497 C C . ARG A 1 330 ? 14.998 76.090 41.094 1.00 51.35 ? 396 ARG A C 1 ATOM 2498 O O . ARG A 1 330 ? 14.397 76.265 40.029 1.00 51.59 ? 396 ARG A O 1 ATOM 2499 C CB . ARG A 1 330 ? 13.769 75.744 43.302 1.00 49.50 ? 396 ARG A CB 1 ATOM 2500 C CG . ARG A 1 330 ? 12.689 76.770 42.939 1.00 61.87 ? 396 ARG A CG 1 ATOM 2501 N N . ASN A 1 331 ? 16.168 76.691 41.383 1.00 46.76 ? 397 ASN A N 1 ATOM 2502 C CA . ASN A 1 331 ? 16.746 77.739 40.550 1.00 45.32 ? 397 ASN A CA 1 ATOM 2503 C C . ASN A 1 331 ? 17.928 77.343 39.674 1.00 48.11 ? 397 ASN A C 1 ATOM 2504 O O . ASN A 1 331 ? 18.403 78.197 38.910 1.00 49.68 ? 397 ASN A O 1 ATOM 2505 C CB . ASN A 1 331 ? 17.124 78.916 41.433 1.00 41.44 ? 397 ASN A CB 1 ATOM 2506 C CG . ASN A 1 331 ? 15.915 79.479 42.123 1.00 54.17 ? 397 ASN A CG 1 ATOM 2507 O OD1 . ASN A 1 331 ? 14.893 79.749 41.489 1.00 55.85 ? 397 ASN A OD1 1 ATOM 2508 N ND2 . ASN A 1 331 ? 15.968 79.616 43.437 1.00 43.62 ? 397 ASN A ND2 1 ATOM 2509 N N . ASN A 1 332 ? 18.381 76.077 39.734 1.00 40.94 ? 398 ASN A N 1 ATOM 2510 C CA . ASN A 1 332 ? 19.544 75.596 38.985 1.00 40.44 ? 398 ASN A CA 1 ATOM 2511 C C . ASN A 1 332 ? 20.762 76.483 39.195 1.00 44.11 ? 398 ASN A C 1 ATOM 2512 O O . ASN A 1 332 ? 21.328 77.047 38.248 1.00 43.00 ? 398 ASN A O 1 ATOM 2513 C CB . ASN A 1 332 ? 19.243 75.364 37.507 1.00 42.22 ? 398 ASN A CB 1 ATOM 2514 C CG . ASN A 1 332 ? 18.379 74.169 37.298 1.00 57.25 ? 398 ASN A CG 1 ATOM 2515 O OD1 . ASN A 1 332 ? 17.235 74.297 36.895 1.00 61.63 ? 398 ASN A OD1 1 ATOM 2516 N ND2 . ASN A 1 332 ? 18.873 73.005 37.682 1.00 41.30 ? 398 ASN A ND2 1 ATOM 2517 N N . ARG A 1 333 ? 21.172 76.590 40.468 1.00 40.24 ? 399 ARG A N 1 ATOM 2518 C CA . ARG A 1 333 ? 22.313 77.398 40.875 1.00 39.09 ? 399 ARG A CA 1 ATOM 2519 C C . ARG A 1 333 ? 22.956 76.819 42.125 1.00 40.49 ? 399 ARG A C 1 ATOM 2520 O O . ARG A 1 333 ? 22.349 75.999 42.819 1.00 38.98 ? 399 ARG A O 1 ATOM 2521 C CB . ARG A 1 333 ? 21.881 78.872 41.104 1.00 39.66 ? 399 ARG A CB 1 ATOM 2522 C CG . ARG A 1 333 ? 20.858 79.029 42.214 1.00 41.87 ? 399 ARG A CG 1 ATOM 2523 C CD . ARG A 1 333 ? 20.396 80.430 42.371 1.00 44.81 ? 399 ARG A CD 1 ATOM 2524 N NE . ARG A 1 333 ? 19.618 80.556 43.605 1.00 46.15 ? 399 ARG A NE 1 ATOM 2525 C CZ . ARG A 1 333 ? 19.299 81.714 44.171 1.00 54.28 ? 399 ARG A CZ 1 ATOM 2526 N NH1 . ARG A 1 333 ? 19.670 82.862 43.609 1.00 36.34 ? 399 ARG A NH1 1 ATOM 2527 N NH2 . ARG A 1 333 ? 18.619 81.736 45.310 1.00 41.44 ? 399 ARG A NH2 1 ATOM 2528 N N . ILE A 1 334 ? 24.175 77.285 42.416 1.00 36.49 ? 400 ILE A N 1 ATOM 2529 C CA . ILE A 1 334 ? 24.971 76.907 43.575 1.00 34.86 ? 400 ILE A CA 1 ATOM 2530 C C . ILE A 1 334 ? 25.301 78.172 44.342 1.00 37.95 ? 400 ILE A C 1 ATOM 2531 O O . ILE A 1 334 ? 25.751 79.151 43.754 1.00 35.60 ? 400 ILE A O 1 ATOM 2532 C CB . ILE A 1 334 ? 26.260 76.100 43.166 1.00 36.85 ? 400 ILE A CB 1 ATOM 2533 C CG1 . ILE A 1 334 ? 25.868 74.769 42.455 1.00 36.07 ? 400 ILE A CG1 1 ATOM 2534 C CG2 . ILE A 1 334 ? 27.186 75.842 44.381 1.00 36.78 ? 400 ILE A CG2 1 ATOM 2535 C CD1 . ILE A 1 334 ? 26.974 74.051 41.740 1.00 36.21 ? 400 ILE A CD1 1 ATOM 2536 N N . GLY A 1 335 ? 25.070 78.139 45.646 1.00 36.18 ? 401 GLY A N 1 ATOM 2537 C CA . GLY A 1 335 ? 25.413 79.260 46.515 1.00 36.19 ? 401 GLY A CA 1 ATOM 2538 C C . GLY A 1 335 ? 26.588 78.942 47.416 1.00 38.46 ? 401 GLY A C 1 ATOM 2539 O O . GLY A 1 335 ? 26.644 77.846 47.966 1.00 38.51 ? 401 GLY A O 1 ATOM 2540 N N . PHE A 1 336 ? 27.527 79.895 47.568 1.00 33.63 ? 402 PHE A N 1 ATOM 2541 C CA . PHE A 1 336 ? 28.687 79.790 48.445 1.00 33.36 ? 402 PHE A CA 1 ATOM 2542 C C . PHE A 1 336 ? 28.679 80.899 49.486 1.00 38.44 ? 402 PHE A C 1 ATOM 2543 O O . PHE A 1 336 ? 28.333 82.036 49.189 1.00 38.26 ? 402 PHE A O 1 ATOM 2544 C CB . PHE A 1 336 ? 30.026 79.858 47.668 1.00 35.00 ? 402 PHE A CB 1 ATOM 2545 C CG . PHE A 1 336 ? 30.283 78.743 46.684 1.00 36.55 ? 402 PHE A CG 1 ATOM 2546 C CD1 . PHE A 1 336 ? 30.468 77.435 47.121 1.00 40.00 ? 402 PHE A CD1 1 ATOM 2547 C CD2 . PHE A 1 336 ? 30.407 79.011 45.319 1.00 37.36 ? 402 PHE A CD2 1 ATOM 2548 C CE1 . PHE A 1 336 ? 30.704 76.405 46.205 1.00 39.98 ? 402 PHE A CE1 1 ATOM 2549 C CE2 . PHE A 1 336 ? 30.679 77.987 44.412 1.00 39.25 ? 402 PHE A CE2 1 ATOM 2550 C CZ . PHE A 1 336 ? 30.837 76.693 44.863 1.00 37.20 ? 402 PHE A CZ 1 ATOM 2551 N N . ALA A 1 337 ? 29.071 80.567 50.704 1.00 34.47 ? 403 ALA A N 1 ATOM 2552 C CA . ALA A 1 337 ? 29.203 81.517 51.801 1.00 33.50 ? 403 ALA A CA 1 ATOM 2553 C C . ALA A 1 337 ? 30.368 81.016 52.632 1.00 36.68 ? 403 ALA A C 1 ATOM 2554 O O . ALA A 1 337 ? 30.621 79.819 52.636 1.00 37.45 ? 403 ALA A O 1 ATOM 2555 C CB . ALA A 1 337 ? 27.924 81.575 52.634 1.00 33.74 ? 403 ALA A CB 1 ATOM 2556 N N . LEU A 1 338 ? 31.084 81.925 53.308 1.00 31.77 ? 404 LEU A N 1 ATOM 2557 C CA . LEU A 1 338 ? 32.228 81.604 54.155 1.00 30.21 ? 404 LEU A CA 1 ATOM 2558 C C . LEU A 1 338 ? 31.782 80.697 55.312 1.00 33.10 ? 404 LEU A C 1 ATOM 2559 O O . LEU A 1 338 ? 30.903 81.064 56.085 1.00 33.35 ? 404 LEU A O 1 ATOM 2560 C CB . LEU A 1 338 ? 32.876 82.907 54.662 1.00 28.98 ? 404 LEU A CB 1 ATOM 2561 C CG . LEU A 1 338 ? 34.224 82.794 55.368 1.00 32.72 ? 404 LEU A CG 1 ATOM 2562 C CD1 . LEU A 1 338 ? 35.341 82.220 54.424 1.00 31.12 ? 404 LEU A CD1 1 ATOM 2563 C CD2 . LEU A 1 338 ? 34.597 84.140 56.044 1.00 33.13 ? 404 LEU A CD2 1 ATOM 2564 N N . ALA A 1 339 ? 32.327 79.495 55.373 1.00 30.02 ? 405 ALA A N 1 ATOM 2565 C CA . ALA A 1 339 ? 31.981 78.512 56.391 1.00 29.26 ? 405 ALA A CA 1 ATOM 2566 C C . ALA A 1 339 ? 32.509 78.913 57.766 1.00 33.45 ? 405 ALA A C 1 ATOM 2567 O O . ALA A 1 339 ? 33.511 79.641 57.867 1.00 31.66 ? 405 ALA A O 1 ATOM 2568 C CB . ALA A 1 339 ? 32.535 77.152 56.003 1.00 29.82 ? 405 ALA A CB 1 ATOM 2569 N N . ARG A 1 340 ? 31.816 78.444 58.828 1.00 32.01 ? 406 ARG A N 1 ATOM 2570 C CA . ARG A 1 340 ? 32.232 78.652 60.222 1.00 37.38 ? 406 ARG A CA 1 ATOM 2571 C C . ARG A 1 340 ? 31.893 77.460 61.141 1.00 53.48 ? 406 ARG A C 1 ATOM 2572 O O . ARG A 1 340 ? 32.599 77.315 62.162 1.00 65.16 ? 406 ARG A O 1 ATOM 2573 C CB . ARG A 1 340 ? 31.696 79.976 60.797 1.00 35.07 ? 406 ARG A CB 1 ATOM 2574 C CG . ARG A 1 340 ? 30.200 80.024 61.000 1.00 37.05 ? 406 ARG A CG 1 ATOM 2575 C CD . ARG A 1 340 ? 29.819 81.266 61.720 1.00 37.95 ? 406 ARG A CD 1 ATOM 2576 N NE . ARG A 1 340 ? 28.379 81.366 61.825 1.00 50.69 ? 406 ARG A NE 1 ATOM 2577 C CZ . ARG A 1 340 ? 27.752 82.451 62.246 1.00 76.05 ? 406 ARG A CZ 1 ATOM 2578 N NH1 . ARG A 1 340 ? 28.445 83.529 62.609 1.00 54.74 ? 406 ARG A NH1 1 ATOM 2579 N NH2 . ARG A 1 340 ? 26.425 82.475 62.306 1.00 73.53 ? 406 ARG A NH2 1 ATOM 2580 O OXT . ARG A 1 340 ? 30.929 76.691 60.852 1.00 48.70 ? 406 ARG A OXT 1 ATOM 2581 N N . LEU B 1 1 ? 26.073 103.447 72.216 1.00 76.56 ? 67 LEU B N 1 ATOM 2582 C CA . LEU B 1 1 ? 26.289 102.113 71.648 1.00 76.01 ? 67 LEU B CA 1 ATOM 2583 C C . LEU B 1 1 ? 24.988 101.480 71.137 1.00 78.42 ? 67 LEU B C 1 ATOM 2584 O O . LEU B 1 1 ? 23.957 101.505 71.822 1.00 77.69 ? 67 LEU B O 1 ATOM 2585 C CB . LEU B 1 1 ? 27.017 101.166 72.658 1.00 75.91 ? 67 LEU B CB 1 ATOM 2586 C CG . LEU B 1 1 ? 26.957 99.619 72.427 1.00 80.28 ? 67 LEU B CG 1 ATOM 2587 C CD1 . LEU B 1 1 ? 27.839 99.181 71.285 1.00 79.81 ? 67 LEU B CD1 1 ATOM 2588 C CD2 . LEU B 1 1 ? 27.364 98.846 73.675 1.00 83.50 ? 67 LEU B CD2 1 ATOM 2589 N N . THR B 1 2 ? 25.063 100.894 69.933 1.00 73.46 ? 68 THR B N 1 ATOM 2590 C CA . THR B 1 2 ? 23.961 100.153 69.331 1.00 72.33 ? 68 THR B CA 1 ATOM 2591 C C . THR B 1 2 ? 24.376 98.673 69.208 1.00 72.06 ? 68 THR B C 1 ATOM 2592 O O . THR B 1 2 ? 25.519 98.366 68.839 1.00 71.44 ? 68 THR B O 1 ATOM 2593 C CB . THR B 1 2 ? 23.485 100.811 68.021 1.00 84.60 ? 68 THR B CB 1 ATOM 2594 O OG1 . THR B 1 2 ? 23.191 102.190 68.277 1.00 90.65 ? 68 THR B OG1 1 ATOM 2595 C CG2 . THR B 1 2 ? 22.245 100.125 67.429 1.00 80.06 ? 68 THR B CG2 1 ATOM 2596 N N . LEU B 1 3 ? 23.450 97.766 69.573 1.00 64.70 ? 69 LEU B N 1 ATOM 2597 C CA . LEU B 1 3 ? 23.666 96.322 69.513 1.00 62.04 ? 69 LEU B CA 1 ATOM 2598 C C . LEU B 1 3 ? 22.680 95.641 68.554 1.00 64.01 ? 69 LEU B C 1 ATOM 2599 O O . LEU B 1 3 ? 21.491 95.975 68.535 1.00 64.38 ? 69 LEU B O 1 ATOM 2600 C CB . LEU B 1 3 ? 23.613 95.673 70.926 1.00 61.16 ? 69 LEU B CB 1 ATOM 2601 C CG . LEU B 1 3 ? 24.731 96.023 71.944 1.00 64.06 ? 69 LEU B CG 1 ATOM 2602 C CD1 . LEU B 1 3 ? 24.446 95.384 73.286 1.00 63.74 ? 69 LEU B CD1 1 ATOM 2603 C CD2 . LEU B 1 3 ? 26.131 95.600 71.451 1.00 63.18 ? 69 LEU B CD2 1 ATOM 2604 N N . GLY B 1 4 ? 23.207 94.719 67.755 1.00 58.04 ? 70 GLY B N 1 ATOM 2605 C CA . GLY B 1 4 ? 22.449 93.919 66.808 1.00 56.67 ? 70 GLY B CA 1 ATOM 2606 C C . GLY B 1 4 ? 22.314 92.500 67.313 1.00 58.32 ? 70 GLY B C 1 ATOM 2607 O O . GLY B 1 4 ? 22.253 92.272 68.527 1.00 56.31 ? 70 GLY B O 1 ATOM 2608 N N . ASN B 1 5 ? 22.234 91.548 66.378 1.00 55.01 ? 71 ASN B N 1 ATOM 2609 C CA . ASN B 1 5 ? 22.049 90.124 66.665 1.00 54.75 ? 71 ASN B CA 1 ATOM 2610 C C . ASN B 1 5 ? 23.078 89.222 65.925 1.00 55.90 ? 71 ASN B C 1 ATOM 2611 O O . ASN B 1 5 ? 22.799 88.054 65.652 1.00 55.81 ? 71 ASN B O 1 ATOM 2612 C CB . ASN B 1 5 ? 20.579 89.709 66.371 1.00 58.59 ? 71 ASN B CB 1 ATOM 2613 C CG . ASN B 1 5 ? 20.156 89.698 64.905 1.00 92.70 ? 71 ASN B CG 1 ATOM 2614 O OD1 . ASN B 1 5 ? 20.474 90.606 64.121 1.00 88.10 ? 71 ASN B OD1 1 ATOM 2615 N ND2 . ASN B 1 5 ? 19.385 88.680 64.512 1.00 86.95 ? 71 ASN B ND2 1 ATOM 2616 N N . THR B 1 6 ? 24.260 89.766 65.586 1.00 49.88 ? 72 THR B N 1 ATOM 2617 C CA . THR B 1 6 ? 25.256 88.938 64.907 1.00 48.56 ? 72 THR B CA 1 ATOM 2618 C C . THR B 1 6 ? 26.614 88.857 65.626 1.00 47.45 ? 72 THR B C 1 ATOM 2619 O O . THR B 1 6 ? 26.969 89.663 66.501 1.00 43.71 ? 72 THR B O 1 ATOM 2620 C CB . THR B 1 6 ? 25.468 89.320 63.416 1.00 54.62 ? 72 THR B CB 1 ATOM 2621 O OG1 . THR B 1 6 ? 26.111 90.586 63.309 1.00 49.43 ? 72 THR B OG1 1 ATOM 2622 C CG2 . THR B 1 6 ? 24.197 89.258 62.576 1.00 52.32 ? 72 THR B CG2 1 ATOM 2623 N N . THR B 1 7 ? 27.338 87.811 65.238 1.00 43.04 ? 73 THR B N 1 ATOM 2624 C CA . THR B 1 7 ? 28.708 87.506 65.597 1.00 42.18 ? 73 THR B CA 1 ATOM 2625 C C . THR B 1 7 ? 29.398 87.220 64.284 1.00 45.86 ? 73 THR B C 1 ATOM 2626 O O . THR B 1 7 ? 28.737 86.908 63.278 1.00 47.45 ? 73 THR B O 1 ATOM 2627 C CB . THR B 1 7 ? 28.823 86.290 66.525 1.00 44.00 ? 73 THR B CB 1 ATOM 2628 O OG1 . THR B 1 7 ? 28.245 85.141 65.897 1.00 41.40 ? 73 THR B OG1 1 ATOM 2629 C CG2 . THR B 1 7 ? 28.265 86.548 67.919 1.00 38.74 ? 73 THR B CG2 1 ATOM 2630 N N . SER B 1 8 ? 30.716 87.279 64.290 1.00 40.10 ? 74 SER B N 1 ATOM 2631 C CA . SER B 1 8 ? 31.521 86.987 63.114 1.00 39.23 ? 74 SER B CA 1 ATOM 2632 C C . SER B 1 8 ? 32.802 86.303 63.549 1.00 41.93 ? 74 SER B C 1 ATOM 2633 O O . SER B 1 8 ? 33.487 86.773 64.453 1.00 43.58 ? 74 SER B O 1 ATOM 2634 C CB . SER B 1 8 ? 31.796 88.263 62.339 1.00 42.06 ? 74 SER B CB 1 ATOM 2635 O OG . SER B 1 8 ? 32.713 88.043 61.280 1.00 49.71 ? 74 SER B OG 1 ATOM 2636 N N . SER B 1 9 ? 33.096 85.162 62.952 1.00 36.75 ? 75 SER B N 1 ATOM 2637 C CA . SER B 1 9 ? 34.268 84.405 63.341 1.00 35.56 ? 75 SER B CA 1 ATOM 2638 C C . SER B 1 9 ? 35.351 84.326 62.241 1.00 39.11 ? 75 SER B C 1 ATOM 2639 O O . SER B 1 9 ? 35.058 84.278 61.040 1.00 37.94 ? 75 SER B O 1 ATOM 2640 C CB . SER B 1 9 ? 33.867 83.024 63.856 1.00 36.05 ? 75 SER B CB 1 ATOM 2641 O OG . SER B 1 9 ? 33.576 82.127 62.804 1.00 50.64 ? 75 SER B OG 1 ATOM 2642 N N . VAL B 1 10 ? 36.607 84.335 62.666 1.00 34.49 ? 76 VAL B N 1 ATOM 2643 C CA . VAL B 1 10 ? 37.743 84.217 61.759 1.00 33.87 ? 76 VAL B CA 1 ATOM 2644 C C . VAL B 1 10 ? 38.550 83.017 62.197 1.00 35.97 ? 76 VAL B C 1 ATOM 2645 O O . VAL B 1 10 ? 38.951 82.954 63.358 1.00 34.93 ? 76 VAL B O 1 ATOM 2646 C CB . VAL B 1 10 ? 38.593 85.524 61.603 1.00 36.78 ? 76 VAL B CB 1 ATOM 2647 C CG1 . VAL B 1 10 ? 39.765 85.321 60.646 1.00 36.58 ? 76 VAL B CG1 1 ATOM 2648 C CG2 . VAL B 1 10 ? 37.729 86.675 61.122 1.00 36.14 ? 76 VAL B CG2 1 ATOM 2649 N N . ILE B 1 11 ? 38.736 82.043 61.283 1.00 32.18 ? 77 ILE B N 1 ATOM 2650 C CA . ILE B 1 11 ? 39.543 80.851 61.543 1.00 32.21 ? 77 ILE B CA 1 ATOM 2651 C C . ILE B 1 11 ? 41.026 81.273 61.517 1.00 35.32 ? 77 ILE B C 1 ATOM 2652 O O . ILE B 1 11 ? 41.455 81.965 60.592 1.00 36.66 ? 77 ILE B O 1 ATOM 2653 C CB . ILE B 1 11 ? 39.236 79.692 60.538 1.00 35.38 ? 77 ILE B CB 1 ATOM 2654 C CG1 . ILE B 1 11 ? 37.753 79.198 60.618 1.00 36.36 ? 77 ILE B CG1 1 ATOM 2655 C CG2 . ILE B 1 11 ? 40.231 78.529 60.664 1.00 34.43 ? 77 ILE B CG2 1 ATOM 2656 C CD1 . ILE B 1 11 ? 37.139 78.959 62.050 1.00 46.23 ? 77 ILE B CD1 1 ATOM 2657 N N . LEU B 1 12 ? 41.786 80.875 62.530 1.00 29.86 ? 78 LEU B N 1 ATOM 2658 C CA . LEU B 1 12 ? 43.202 81.219 62.608 1.00 29.38 ? 78 LEU B CA 1 ATOM 2659 C C . LEU B 1 12 ? 44.059 80.023 62.319 1.00 35.69 ? 78 LEU B C 1 ATOM 2660 O O . LEU B 1 12 ? 43.667 78.886 62.584 1.00 36.41 ? 78 LEU B O 1 ATOM 2661 C CB . LEU B 1 12 ? 43.600 81.837 63.981 1.00 28.05 ? 78 LEU B CB 1 ATOM 2662 C CG . LEU B 1 12 ? 42.719 82.977 64.545 1.00 30.49 ? 78 LEU B CG 1 ATOM 2663 C CD1 . LEU B 1 12 ? 43.226 83.435 65.906 1.00 28.75 ? 78 LEU B CD1 1 ATOM 2664 C CD2 . LEU B 1 12 ? 42.619 84.152 63.586 1.00 28.98 ? 78 LEU B CD2 1 ATOM 2665 N N . THR B 1 13 ? 45.249 80.286 61.790 1.00 34.27 ? 79 THR B N 1 ATOM 2666 C CA . THR B 1 13 ? 46.279 79.292 61.508 1.00 33.86 ? 79 THR B CA 1 ATOM 2667 C C . THR B 1 13 ? 47.268 79.355 62.662 1.00 36.39 ? 79 THR B C 1 ATOM 2668 O O . THR B 1 13 ? 47.653 80.432 63.092 1.00 36.45 ? 79 THR B O 1 ATOM 2669 C CB . THR B 1 13 ? 46.927 79.595 60.137 1.00 37.25 ? 79 THR B CB 1 ATOM 2670 O OG1 . THR B 1 13 ? 45.941 79.379 59.128 1.00 41.43 ? 79 THR B OG1 1 ATOM 2671 C CG2 . THR B 1 13 ? 48.159 78.734 59.845 1.00 26.53 ? 79 THR B CG2 1 ATOM 2672 N N . ASN B 1 14 ? 47.637 78.205 63.181 1.00 34.04 ? 80 ASN B N 1 ATOM 2673 C CA . ASN B 1 14 ? 48.630 78.133 64.226 1.00 34.41 ? 80 ASN B CA 1 ATOM 2674 C C . ASN B 1 14 ? 49.958 77.744 63.581 1.00 43.03 ? 80 ASN B C 1 ATOM 2675 O O . ASN B 1 14 ? 50.124 76.608 63.114 1.00 43.75 ? 80 ASN B O 1 ATOM 2676 C CB . ASN B 1 14 ? 48.233 77.119 65.308 1.00 27.30 ? 80 ASN B CB 1 ATOM 2677 C CG . ASN B 1 14 ? 49.294 76.882 66.346 1.00 37.78 ? 80 ASN B CG 1 ATOM 2678 O OD1 . ASN B 1 14 ? 50.382 77.462 66.312 1.00 30.43 ? 80 ASN B OD1 1 ATOM 2679 N ND2 . ASN B 1 14 ? 48.990 76.055 67.313 1.00 34.91 ? 80 ASN B ND2 1 ATOM 2680 N N . TYR B 1 15 ? 50.907 78.683 63.596 1.00 39.94 ? 81 TYR B N 1 ATOM 2681 C CA . TYR B 1 15 ? 52.255 78.443 63.131 1.00 38.81 ? 81 TYR B CA 1 ATOM 2682 C C . TYR B 1 15 ? 53.169 78.166 64.337 1.00 39.87 ? 81 TYR B C 1 ATOM 2683 O O . TYR B 1 15 ? 53.512 79.094 65.068 1.00 38.91 ? 81 TYR B O 1 ATOM 2684 C CB . TYR B 1 15 ? 52.785 79.628 62.298 1.00 40.56 ? 81 TYR B CB 1 ATOM 2685 C CG . TYR B 1 15 ? 54.226 79.429 61.869 1.00 43.06 ? 81 TYR B CG 1 ATOM 2686 C CD1 . TYR B 1 15 ? 54.563 78.485 60.901 1.00 45.52 ? 81 TYR B CD1 1 ATOM 2687 C CD2 . TYR B 1 15 ? 55.259 80.139 62.476 1.00 43.33 ? 81 TYR B CD2 1 ATOM 2688 C CE1 . TYR B 1 15 ? 55.890 78.283 60.517 1.00 48.54 ? 81 TYR B CE1 1 ATOM 2689 C CE2 . TYR B 1 15 ? 56.589 79.936 62.112 1.00 44.31 ? 81 TYR B CE2 1 ATOM 2690 C CZ . TYR B 1 15 ? 56.899 79.011 61.128 1.00 52.98 ? 81 TYR B CZ 1 ATOM 2691 O OH . TYR B 1 15 ? 58.204 78.817 60.758 1.00 53.90 ? 81 TYR B OH 1 ATOM 2692 N N . MET B 1 16 ? 53.549 76.892 64.534 1.00 37.27 ? 82 MET B N 1 ATOM 2693 C CA . MET B 1 16 ? 54.498 76.415 65.551 1.00 38.82 ? 82 MET B CA 1 ATOM 2694 C C . MET B 1 16 ? 54.222 76.842 67.045 1.00 41.70 ? 82 MET B C 1 ATOM 2695 O O . MET B 1 16 ? 55.168 76.908 67.843 1.00 39.95 ? 82 MET B O 1 ATOM 2696 C CB . MET B 1 16 ? 55.914 76.870 65.134 1.00 42.27 ? 82 MET B CB 1 ATOM 2697 C CG . MET B 1 16 ? 56.592 75.927 64.176 1.00 47.96 ? 82 MET B CG 1 ATOM 2698 S SD . MET B 1 16 ? 58.107 76.670 63.534 1.00 54.74 ? 82 MET B SD 1 ATOM 2699 C CE . MET B 1 16 ? 58.294 75.770 62.108 1.00 51.59 ? 82 MET B CE 1 ATOM 2700 N N . ASP B 1 17 ? 52.939 77.143 67.410 1.00 36.80 ? 83 ASP B N 1 ATOM 2701 C CA . ASP B 1 17 ? 52.524 77.623 68.742 1.00 35.15 ? 83 ASP B CA 1 ATOM 2702 C C . ASP B 1 17 ? 53.107 79.029 69.051 1.00 36.96 ? 83 ASP B C 1 ATOM 2703 O O . ASP B 1 17 ? 53.071 79.460 70.204 1.00 34.63 ? 83 ASP B O 1 ATOM 2704 C CB . ASP B 1 17 ? 52.878 76.611 69.871 1.00 36.04 ? 83 ASP B CB 1 ATOM 2705 C CG . ASP B 1 17 ? 52.091 75.310 69.922 1.00 42.41 ? 83 ASP B CG 1 ATOM 2706 O OD1 . ASP B 1 17 ? 50.937 75.297 69.478 1.00 39.00 ? 83 ASP B OD1 1 ATOM 2707 O OD2 . ASP B 1 17 ? 52.593 74.341 70.511 1.00 57.23 ? 83 ASP B OD2 1 ATOM 2708 N N . THR B 1 18 ? 53.669 79.728 68.032 1.00 33.53 ? 84 THR B N 1 ATOM 2709 C CA . THR B 1 18 ? 54.271 81.053 68.233 1.00 32.93 ? 84 THR B CA 1 ATOM 2710 C C . THR B 1 18 ? 53.624 82.152 67.399 1.00 34.11 ? 84 THR B C 1 ATOM 2711 O O . THR B 1 18 ? 53.838 83.323 67.710 1.00 33.19 ? 84 THR B O 1 ATOM 2712 C CB . THR B 1 18 ? 55.795 81.036 68.050 1.00 39.54 ? 84 THR B CB 1 ATOM 2713 O OG1 . THR B 1 18 ? 56.117 80.591 66.720 1.00 39.05 ? 84 THR B OG1 1 ATOM 2714 C CG2 . THR B 1 18 ? 56.501 80.180 69.131 1.00 37.79 ? 84 THR B CG2 1 ATOM 2715 N N . GLN B 1 19 ? 52.889 81.809 66.329 1.00 29.68 ? 85 GLN B N 1 ATOM 2716 C CA . GLN B 1 19 ? 52.205 82.820 65.504 1.00 29.42 ? 85 GLN B CA 1 ATOM 2717 C C . GLN B 1 19 ? 50.829 82.322 65.154 1.00 33.71 ? 85 GLN B C 1 ATOM 2718 O O . GLN B 1 19 ? 50.691 81.185 64.709 1.00 34.35 ? 85 GLN B O 1 ATOM 2719 C CB . GLN B 1 19 ? 52.990 83.168 64.221 1.00 30.88 ? 85 GLN B CB 1 ATOM 2720 C CG . GLN B 1 19 ? 54.370 83.767 64.461 1.00 45.31 ? 85 GLN B CG 1 ATOM 2721 C CD . GLN B 1 19 ? 55.145 83.970 63.186 1.00 55.17 ? 85 GLN B CD 1 ATOM 2722 O OE1 . GLN B 1 19 ? 54.654 84.531 62.205 1.00 53.95 ? 85 GLN B OE1 1 ATOM 2723 N NE2 . GLN B 1 19 ? 56.391 83.533 63.192 1.00 34.80 ? 85 GLN B NE2 1 ATOM 2724 N N . TYR B 1 20 ? 49.802 83.142 65.409 1.00 30.03 ? 86 TYR B N 1 ATOM 2725 C CA . TYR B 1 20 ? 48.410 82.823 65.110 1.00 29.37 ? 86 TYR B CA 1 ATOM 2726 C C . TYR B 1 20 ? 47.920 83.961 64.256 1.00 33.89 ? 86 TYR B C 1 ATOM 2727 O O . TYR B 1 20 ? 48.101 85.123 64.615 1.00 33.17 ? 86 TYR B O 1 ATOM 2728 C CB . TYR B 1 20 ? 47.561 82.684 66.389 1.00 29.99 ? 86 TYR B CB 1 ATOM 2729 C CG . TYR B 1 20 ? 47.958 81.523 67.281 1.00 26.90 ? 86 TYR B CG 1 ATOM 2730 C CD1 . TYR B 1 20 ? 49.047 81.621 68.143 1.00 25.98 ? 86 TYR B CD1 1 ATOM 2731 C CD2 . TYR B 1 20 ? 47.222 80.337 67.285 1.00 26.86 ? 86 TYR B CD2 1 ATOM 2732 C CE1 . TYR B 1 20 ? 49.420 80.549 68.959 1.00 26.07 ? 86 TYR B CE1 1 ATOM 2733 C CE2 . TYR B 1 20 ? 47.566 79.275 68.120 1.00 27.26 ? 86 TYR B CE2 1 ATOM 2734 C CZ . TYR B 1 20 ? 48.669 79.385 68.953 1.00 30.92 ? 86 TYR B CZ 1 ATOM 2735 O OH . TYR B 1 20 ? 49.029 78.347 69.772 1.00 32.69 ? 86 TYR B OH 1 ATOM 2736 N N . TYR B 1 21 ? 47.400 83.634 63.078 1.00 31.42 ? 87 TYR B N 1 ATOM 2737 C CA . TYR B 1 21 ? 46.944 84.647 62.129 1.00 31.54 ? 87 TYR B CA 1 ATOM 2738 C C . TYR B 1 21 ? 45.753 84.151 61.333 1.00 36.35 ? 87 TYR B C 1 ATOM 2739 O O . TYR B 1 21 ? 45.583 82.951 61.155 1.00 37.14 ? 87 TYR B O 1 ATOM 2740 C CB . TYR B 1 21 ? 48.092 85.061 61.169 1.00 33.17 ? 87 TYR B CB 1 ATOM 2741 C CG . TYR B 1 21 ? 48.846 83.894 60.566 1.00 33.76 ? 87 TYR B CG 1 ATOM 2742 C CD1 . TYR B 1 21 ? 48.430 83.309 59.375 1.00 34.58 ? 87 TYR B CD1 1 ATOM 2743 C CD2 . TYR B 1 21 ? 49.968 83.357 61.201 1.00 34.76 ? 87 TYR B CD2 1 ATOM 2744 C CE1 . TYR B 1 21 ? 49.109 82.213 58.831 1.00 35.42 ? 87 TYR B CE1 1 ATOM 2745 C CE2 . TYR B 1 21 ? 50.640 82.250 60.676 1.00 35.93 ? 87 TYR B CE2 1 ATOM 2746 C CZ . TYR B 1 21 ? 50.218 81.693 59.487 1.00 42.18 ? 87 TYR B CZ 1 ATOM 2747 O OH . TYR B 1 21 ? 50.924 80.630 58.986 1.00 46.59 ? 87 TYR B OH 1 ATOM 2748 N N . GLY B 1 22 ? 44.944 85.078 60.861 1.00 31.87 ? 88 GLY B N 1 ATOM 2749 C CA . GLY B 1 22 ? 43.772 84.776 60.059 1.00 31.99 ? 88 GLY B CA 1 ATOM 2750 C C . GLY B 1 22 ? 43.733 85.694 58.871 1.00 38.81 ? 88 GLY B C 1 ATOM 2751 O O . GLY B 1 22 ? 44.650 86.504 58.707 1.00 38.97 ? 88 GLY B O 1 ATOM 2752 N N . GLU B 1 23 ? 42.655 85.608 58.064 1.00 34.70 ? 89 GLU B N 1 ATOM 2753 C CA . GLU B 1 23 ? 42.529 86.399 56.852 1.00 34.42 ? 89 GLU B CA 1 ATOM 2754 C C . GLU B 1 23 ? 41.640 87.599 56.943 1.00 38.69 ? 89 GLU B C 1 ATOM 2755 O O . GLU B 1 23 ? 40.576 87.549 57.580 1.00 38.11 ? 89 GLU B O 1 ATOM 2756 C CB . GLU B 1 23 ? 42.060 85.530 55.651 1.00 35.74 ? 89 GLU B CB 1 ATOM 2757 C CG . GLU B 1 23 ? 42.811 84.221 55.459 1.00 53.17 ? 89 GLU B CG 1 ATOM 2758 C CD . GLU B 1 23 ? 44.322 84.290 55.605 1.00 80.97 ? 89 GLU B CD 1 ATOM 2759 O OE1 . GLU B 1 23 ? 44.962 84.929 54.738 1.00 83.38 ? 89 GLU B OE1 1 ATOM 2760 O OE2 . GLU B 1 23 ? 44.861 83.720 56.587 1.00 66.61 ? 89 GLU B OE2 1 ATOM 2761 N N . ILE B 1 24 ? 42.050 88.667 56.229 1.00 34.59 ? 90 ILE B N 1 ATOM 2762 C CA . ILE B 1 24 ? 41.253 89.875 55.994 1.00 35.60 ? 90 ILE B CA 1 ATOM 2763 C C . ILE B 1 24 ? 41.371 90.227 54.514 1.00 43.95 ? 90 ILE B C 1 ATOM 2764 O O . ILE B 1 24 ? 42.417 90.005 53.902 1.00 44.47 ? 90 ILE B O 1 ATOM 2765 C CB . ILE B 1 24 ? 41.507 91.102 56.908 1.00 37.97 ? 90 ILE B CB 1 ATOM 2766 C CG1 . ILE B 1 24 ? 42.939 91.693 56.702 1.00 37.67 ? 90 ILE B CG1 1 ATOM 2767 C CG2 . ILE B 1 24 ? 41.190 90.786 58.385 1.00 38.22 ? 90 ILE B CG2 1 ATOM 2768 C CD1 . ILE B 1 24 ? 43.052 93.251 56.957 1.00 34.43 ? 90 ILE B CD1 1 ATOM 2769 N N . GLY B 1 25 ? 40.293 90.737 53.954 1.00 42.59 ? 91 GLY B N 1 ATOM 2770 C CA . GLY B 1 25 ? 40.268 91.169 52.564 1.00 43.04 ? 91 GLY B CA 1 ATOM 2771 C C . GLY B 1 25 ? 40.233 92.685 52.489 1.00 46.60 ? 91 GLY B C 1 ATOM 2772 O O . GLY B 1 25 ? 39.408 93.312 53.155 1.00 45.05 ? 91 GLY B O 1 ATOM 2773 N N . ILE B 1 26 ? 41.145 93.294 51.722 1.00 45.21 ? 92 ILE B N 1 ATOM 2774 C CA . ILE B 1 26 ? 41.165 94.759 51.576 1.00 46.45 ? 92 ILE B CA 1 ATOM 2775 C C . ILE B 1 26 ? 40.900 95.180 50.121 1.00 53.33 ? 92 ILE B C 1 ATOM 2776 O O . ILE B 1 26 ? 41.556 94.669 49.205 1.00 52.68 ? 92 ILE B O 1 ATOM 2777 C CB . ILE B 1 26 ? 42.447 95.433 52.151 1.00 48.83 ? 92 ILE B CB 1 ATOM 2778 C CG1 . ILE B 1 26 ? 42.811 94.906 53.555 1.00 48.83 ? 92 ILE B CG1 1 ATOM 2779 C CG2 . ILE B 1 26 ? 42.318 96.972 52.138 1.00 48.23 ? 92 ILE B CG2 1 ATOM 2780 C CD1 . ILE B 1 26 ? 44.149 95.330 54.007 1.00 53.10 ? 92 ILE B CD1 1 ATOM 2781 N N . GLY B 1 27 ? 39.949 96.099 49.941 1.00 52.40 ? 93 GLY B N 1 ATOM 2782 C CA . GLY B 1 27 ? 39.604 96.662 48.642 1.00 53.57 ? 93 GLY B CA 1 ATOM 2783 C C . GLY B 1 27 ? 38.521 95.984 47.833 1.00 59.04 ? 93 GLY B C 1 ATOM 2784 O O . GLY B 1 27 ? 37.912 95.013 48.283 1.00 58.90 ? 93 GLY B O 1 ATOM 2785 N N . THR B 1 28 ? 38.255 96.543 46.634 1.00 56.32 ? 94 THR B N 1 ATOM 2786 C CA . THR B 1 28 ? 37.285 96.052 45.650 1.00 55.96 ? 94 THR B CA 1 ATOM 2787 C C . THR B 1 28 ? 38.006 95.858 44.307 1.00 60.80 ? 94 THR B C 1 ATOM 2788 O O . THR B 1 28 ? 38.394 96.856 43.694 1.00 62.11 ? 94 THR B O 1 ATOM 2789 C CB . THR B 1 28 ? 36.063 96.978 45.530 1.00 61.02 ? 94 THR B CB 1 ATOM 2790 O OG1 . THR B 1 28 ? 35.510 97.245 46.820 1.00 60.28 ? 94 THR B OG1 1 ATOM 2791 C CG2 . THR B 1 28 ? 34.979 96.397 44.636 1.00 58.02 ? 94 THR B CG2 1 ATOM 2792 N N . PRO B 1 29 ? 38.213 94.607 43.831 1.00 56.52 ? 95 PRO B N 1 ATOM 2793 C CA . PRO B 1 29 ? 37.888 93.323 44.491 1.00 56.62 ? 95 PRO B CA 1 ATOM 2794 C C . PRO B 1 29 ? 38.827 93.082 45.687 1.00 63.11 ? 95 PRO B C 1 ATOM 2795 O O . PRO B 1 29 ? 39.892 93.718 45.756 1.00 64.33 ? 95 PRO B O 1 ATOM 2796 C CB . PRO B 1 29 ? 38.093 92.291 43.372 1.00 58.19 ? 95 PRO B CB 1 ATOM 2797 C CG . PRO B 1 29 ? 39.153 92.896 42.492 1.00 62.67 ? 95 PRO B CG 1 ATOM 2798 C CD . PRO B 1 29 ? 38.942 94.402 42.563 1.00 57.98 ? 95 PRO B CD 1 ATOM 2799 N N . PRO B 1 30 ? 38.484 92.203 46.660 1.00 58.94 ? 96 PRO B N 1 ATOM 2800 C CA . PRO B 1 30 ? 39.391 92.020 47.805 1.00 57.34 ? 96 PRO B CA 1 ATOM 2801 C C . PRO B 1 30 ? 40.754 91.416 47.482 1.00 58.69 ? 96 PRO B C 1 ATOM 2802 O O . PRO B 1 30 ? 40.877 90.530 46.636 1.00 59.86 ? 96 PRO B O 1 ATOM 2803 C CB . PRO B 1 30 ? 38.593 91.137 48.775 1.00 58.94 ? 96 PRO B CB 1 ATOM 2804 C CG . PRO B 1 30 ? 37.196 91.138 48.273 1.00 63.78 ? 96 PRO B CG 1 ATOM 2805 C CD . PRO B 1 30 ? 37.272 91.369 46.798 1.00 59.95 ? 96 PRO B CD 1 ATOM 2806 N N . GLN B 1 31 ? 41.780 91.962 48.151 1.00 51.41 ? 97 GLN B N 1 ATOM 2807 C CA . GLN B 1 31 ? 43.172 91.506 48.171 1.00 49.67 ? 97 GLN B CA 1 ATOM 2808 C C . GLN B 1 31 ? 43.304 90.923 49.582 1.00 49.66 ? 97 GLN B C 1 ATOM 2809 O O . GLN B 1 31 ? 43.003 91.611 50.558 1.00 49.37 ? 97 GLN B O 1 ATOM 2810 C CB . GLN B 1 31 ? 44.132 92.685 47.979 1.00 50.88 ? 97 GLN B CB 1 ATOM 2811 C CG . GLN B 1 31 ? 43.888 93.432 46.678 1.00 59.71 ? 97 GLN B CG 1 ATOM 2812 C CD . GLN B 1 31 ? 44.778 94.626 46.515 1.00 59.65 ? 97 GLN B CD 1 ATOM 2813 O OE1 . GLN B 1 31 ? 45.980 94.600 46.830 1.00 52.15 ? 97 GLN B OE1 1 ATOM 2814 N NE2 . GLN B 1 31 ? 44.197 95.686 45.972 1.00 48.52 ? 97 GLN B NE2 1 ATOM 2815 N N . THR B 1 32 ? 43.658 89.647 49.687 1.00 44.14 ? 98 THR B N 1 ATOM 2816 C CA . THR B 1 32 ? 43.681 88.932 50.958 1.00 43.35 ? 98 THR B CA 1 ATOM 2817 C C . THR B 1 32 ? 45.025 88.935 51.634 1.00 46.97 ? 98 THR B C 1 ATOM 2818 O O . THR B 1 32 ? 46.049 88.757 50.981 1.00 45.93 ? 98 THR B O 1 ATOM 2819 C CB . THR B 1 32 ? 43.146 87.504 50.798 1.00 51.48 ? 98 THR B CB 1 ATOM 2820 O OG1 . THR B 1 32 ? 43.988 86.800 49.885 1.00 57.45 ? 98 THR B OG1 1 ATOM 2821 C CG2 . THR B 1 32 ? 41.696 87.465 50.331 1.00 44.26 ? 98 THR B CG2 1 ATOM 2822 N N . PHE B 1 33 ? 45.009 89.099 52.968 1.00 44.37 ? 99 PHE B N 1 ATOM 2823 C CA . PHE B 1 33 ? 46.220 89.142 53.801 1.00 44.19 ? 99 PHE B CA 1 ATOM 2824 C C . PHE B 1 33 ? 46.125 88.249 55.018 1.00 46.30 ? 99 PHE B C 1 ATOM 2825 O O . PHE B 1 33 ? 45.034 88.083 55.574 1.00 44.64 ? 99 PHE B O 1 ATOM 2826 C CB . PHE B 1 33 ? 46.451 90.580 54.280 1.00 46.24 ? 99 PHE B CB 1 ATOM 2827 C CG . PHE B 1 33 ? 46.801 91.514 53.153 1.00 48.04 ? 99 PHE B CG 1 ATOM 2828 C CD1 . PHE B 1 33 ? 48.122 91.660 52.736 1.00 50.45 ? 99 PHE B CD1 1 ATOM 2829 C CD2 . PHE B 1 33 ? 45.807 92.223 52.481 1.00 50.03 ? 99 PHE B CD2 1 ATOM 2830 C CE1 . PHE B 1 33 ? 48.443 92.510 51.680 1.00 51.79 ? 99 PHE B CE1 1 ATOM 2831 C CE2 . PHE B 1 33 ? 46.125 93.062 51.413 1.00 52.80 ? 99 PHE B CE2 1 ATOM 2832 C CZ . PHE B 1 33 ? 47.439 93.190 51.014 1.00 51.39 ? 99 PHE B CZ 1 ATOM 2833 N N . LYS B 1 34 ? 47.281 87.709 55.456 1.00 41.87 ? 100 LYS B N 1 ATOM 2834 C CA . LYS B 1 34 ? 47.421 86.943 56.698 1.00 39.51 ? 100 LYS B CA 1 ATOM 2835 C C . LYS B 1 34 ? 47.722 87.998 57.774 1.00 43.28 ? 100 LYS B C 1 ATOM 2836 O O . LYS B 1 34 ? 48.672 88.761 57.634 1.00 42.47 ? 100 LYS B O 1 ATOM 2837 C CB . LYS B 1 34 ? 48.557 85.928 56.593 1.00 39.49 ? 100 LYS B CB 1 ATOM 2838 C CG . LYS B 1 34 ? 48.227 84.761 55.673 1.00 40.89 ? 100 LYS B CG 1 ATOM 2839 C CD . LYS B 1 34 ? 49.474 83.987 55.277 1.00 51.14 ? 100 LYS B CD 1 ATOM 2840 C CE . LYS B 1 34 ? 49.151 83.003 54.184 1.00 61.82 ? 100 LYS B CE 1 ATOM 2841 N NZ . LYS B 1 34 ? 50.380 82.363 53.643 1.00 74.83 ? 100 LYS B NZ 1 ATOM 2842 N N . VAL B 1 35 ? 46.850 88.129 58.775 1.00 38.66 ? 101 VAL B N 1 ATOM 2843 C CA . VAL B 1 35 ? 47.022 89.154 59.815 1.00 37.71 ? 101 VAL B CA 1 ATOM 2844 C C . VAL B 1 35 ? 46.950 88.579 61.237 1.00 41.17 ? 101 VAL B C 1 ATOM 2845 O O . VAL B 1 35 ? 46.232 87.606 61.485 1.00 39.92 ? 101 VAL B O 1 ATOM 2846 C CB . VAL B 1 35 ? 46.058 90.357 59.645 1.00 40.34 ? 101 VAL B CB 1 ATOM 2847 C CG1 . VAL B 1 35 ? 46.381 91.147 58.393 1.00 40.43 ? 101 VAL B CG1 1 ATOM 2848 C CG2 . VAL B 1 35 ? 44.601 89.907 59.644 1.00 39.71 ? 101 VAL B CG2 1 ATOM 2849 N N . VAL B 1 36 ? 47.692 89.206 62.157 1.00 37.15 ? 102 VAL B N 1 ATOM 2850 C CA . VAL B 1 36 ? 47.662 88.911 63.580 1.00 37.47 ? 102 VAL B CA 1 ATOM 2851 C C . VAL B 1 36 ? 46.549 89.795 64.148 1.00 39.88 ? 102 VAL B C 1 ATOM 2852 O O . VAL B 1 36 ? 46.565 91.016 63.913 1.00 38.35 ? 102 VAL B O 1 ATOM 2853 C CB . VAL B 1 36 ? 49.008 89.256 64.285 1.00 41.77 ? 102 VAL B CB 1 ATOM 2854 C CG1 . VAL B 1 36 ? 48.931 88.988 65.794 1.00 41.16 ? 102 VAL B CG1 1 ATOM 2855 C CG2 . VAL B 1 36 ? 50.159 88.484 63.674 1.00 41.84 ? 102 VAL B CG2 1 ATOM 2856 N N . PHE B 1 37 ? 45.592 89.194 64.910 1.00 34.14 ? 103 PHE B N 1 ATOM 2857 C CA . PHE B 1 37 ? 44.559 89.983 65.593 1.00 31.60 ? 103 PHE B CA 1 ATOM 2858 C C . PHE B 1 37 ? 45.198 90.217 66.955 1.00 36.80 ? 103 PHE B C 1 ATOM 2859 O O . PHE B 1 37 ? 45.406 89.286 67.747 1.00 37.11 ? 103 PHE B O 1 ATOM 2860 C CB . PHE B 1 37 ? 43.211 89.277 65.609 1.00 31.80 ? 103 PHE B CB 1 ATOM 2861 C CG . PHE B 1 37 ? 42.656 89.068 64.212 1.00 32.01 ? 103 PHE B CG 1 ATOM 2862 C CD1 . PHE B 1 37 ? 42.977 87.928 63.484 1.00 32.63 ? 103 PHE B CD1 1 ATOM 2863 C CD2 . PHE B 1 37 ? 41.820 90.018 63.624 1.00 33.19 ? 103 PHE B CD2 1 ATOM 2864 C CE1 . PHE B 1 37 ? 42.460 87.727 62.199 1.00 34.00 ? 103 PHE B CE1 1 ATOM 2865 C CE2 . PHE B 1 37 ? 41.308 89.823 62.334 1.00 35.15 ? 103 PHE B CE2 1 ATOM 2866 C CZ . PHE B 1 37 ? 41.630 88.676 61.631 1.00 33.52 ? 103 PHE B CZ 1 ATOM 2867 N N . ASP B 1 38 ? 45.660 91.457 67.138 1.00 33.80 ? 104 ASP B N 1 ATOM 2868 C CA . ASP B 1 38 ? 46.554 91.860 68.216 1.00 34.63 ? 104 ASP B CA 1 ATOM 2869 C C . ASP B 1 38 ? 45.992 92.825 69.278 1.00 37.39 ? 104 ASP B C 1 ATOM 2870 O O . ASP B 1 38 ? 45.823 94.010 68.994 1.00 37.54 ? 104 ASP B O 1 ATOM 2871 C CB . ASP B 1 38 ? 47.796 92.460 67.532 1.00 36.53 ? 104 ASP B CB 1 ATOM 2872 C CG . ASP B 1 38 ? 48.927 92.864 68.428 1.00 46.33 ? 104 ASP B CG 1 ATOM 2873 O OD1 . ASP B 1 38 ? 49.111 92.217 69.488 1.00 46.76 ? 104 ASP B OD1 1 ATOM 2874 O OD2 . ASP B 1 38 ? 49.656 93.802 68.059 1.00 50.26 ? 104 ASP B OD2 1 ATOM 2875 N N . THR B 1 39 ? 45.800 92.334 70.528 1.00 32.20 ? 105 THR B N 1 ATOM 2876 C CA . THR B 1 39 ? 45.309 93.173 71.635 1.00 31.48 ? 105 THR B CA 1 ATOM 2877 C C . THR B 1 39 ? 46.411 94.087 72.204 1.00 36.52 ? 105 THR B C 1 ATOM 2878 O O . THR B 1 39 ? 46.098 95.030 72.933 1.00 36.69 ? 105 THR B O 1 ATOM 2879 C CB . THR B 1 39 ? 44.609 92.356 72.735 1.00 32.04 ? 105 THR B CB 1 ATOM 2880 O OG1 . THR B 1 39 ? 45.529 91.394 73.260 1.00 32.03 ? 105 THR B OG1 1 ATOM 2881 C CG2 . THR B 1 39 ? 43.328 91.693 72.245 1.00 27.09 ? 105 THR B CG2 1 ATOM 2882 N N . GLY B 1 40 ? 47.669 93.825 71.843 1.00 33.01 ? 106 GLY B N 1 ATOM 2883 C CA . GLY B 1 40 ? 48.808 94.636 72.259 1.00 33.08 ? 106 GLY B CA 1 ATOM 2884 C C . GLY B 1 40 ? 49.141 95.804 71.333 1.00 37.85 ? 106 GLY B C 1 ATOM 2885 O O . GLY B 1 40 ? 50.206 96.389 71.473 1.00 39.18 ? 106 GLY B O 1 ATOM 2886 N N . SER B 1 41 ? 48.265 96.148 70.367 1.00 35.27 ? 107 SER B N 1 ATOM 2887 C CA . SER B 1 41 ? 48.434 97.279 69.419 1.00 35.45 ? 107 SER B CA 1 ATOM 2888 C C . SER B 1 41 ? 47.063 97.731 68.911 1.00 39.02 ? 107 SER B C 1 ATOM 2889 O O . SER B 1 41 ? 46.097 96.983 69.086 1.00 37.84 ? 107 SER B O 1 ATOM 2890 C CB . SER B 1 41 ? 49.376 96.929 68.266 1.00 38.38 ? 107 SER B CB 1 ATOM 2891 O OG . SER B 1 41 ? 48.725 96.169 67.262 1.00 48.12 ? 107 SER B OG 1 ATOM 2892 N N . SER B 1 42 ? 46.961 98.949 68.319 1.00 35.39 ? 108 SER B N 1 ATOM 2893 C CA . SER B 1 42 ? 45.663 99.494 67.922 1.00 35.10 ? 108 SER B CA 1 ATOM 2894 C C . SER B 1 42 ? 45.554 99.935 66.459 1.00 40.90 ? 108 SER B C 1 ATOM 2895 O O . SER B 1 42 ? 44.542 100.531 66.076 1.00 40.08 ? 108 SER B O 1 ATOM 2896 C CB . SER B 1 42 ? 45.275 100.642 68.849 1.00 38.29 ? 108 SER B CB 1 ATOM 2897 O OG . SER B 1 42 ? 45.524 100.366 70.221 1.00 45.00 ? 108 SER B OG 1 ATOM 2898 N N . ASN B 1 43 ? 46.556 99.604 65.630 1.00 38.85 ? 109 ASN B N 1 ATOM 2899 C CA . ASN B 1 43 ? 46.535 100.006 64.224 1.00 39.23 ? 109 ASN B CA 1 ATOM 2900 C C . ASN B 1 43 ? 46.430 98.844 63.286 1.00 42.37 ? 109 ASN B C 1 ATOM 2901 O O . ASN B 1 43 ? 46.953 97.775 63.573 1.00 40.47 ? 109 ASN B O 1 ATOM 2902 C CB . ASN B 1 43 ? 47.790 100.827 63.864 1.00 42.35 ? 109 ASN B CB 1 ATOM 2903 C CG . ASN B 1 43 ? 47.854 102.163 64.534 1.00 56.62 ? 109 ASN B CG 1 ATOM 2904 O OD1 . ASN B 1 43 ? 48.166 102.275 65.715 1.00 51.46 ? 109 ASN B OD1 1 ATOM 2905 N ND2 . ASN B 1 43 ? 47.585 103.204 63.776 1.00 54.58 ? 109 ASN B ND2 1 ATOM 2906 N N . VAL B 1 44 ? 45.767 99.064 62.133 1.00 39.01 ? 110 VAL B N 1 ATOM 2907 C CA . VAL B 1 44 ? 45.672 98.071 61.075 1.00 37.20 ? 110 VAL B CA 1 ATOM 2908 C C . VAL B 1 44 ? 46.773 98.458 60.098 1.00 45.08 ? 110 VAL B C 1 ATOM 2909 O O . VAL B 1 44 ? 46.934 99.643 59.794 1.00 47.21 ? 110 VAL B O 1 ATOM 2910 C CB . VAL B 1 44 ? 44.287 98.051 60.378 1.00 38.57 ? 110 VAL B CB 1 ATOM 2911 C CG1 . VAL B 1 44 ? 44.278 97.068 59.201 1.00 37.98 ? 110 VAL B CG1 1 ATOM 2912 C CG2 . VAL B 1 44 ? 43.166 97.718 61.362 1.00 37.59 ? 110 VAL B CG2 1 ATOM 2913 N N . TRP B 1 45 ? 47.557 97.480 59.646 1.00 41.04 ? 111 TRP B N 1 ATOM 2914 C CA . TRP B 1 45 ? 48.581 97.694 58.643 1.00 40.81 ? 111 TRP B CA 1 ATOM 2915 C C . TRP B 1 45 ? 48.857 96.429 57.871 1.00 48.37 ? 111 TRP B C 1 ATOM 2916 O O . TRP B 1 45 ? 48.763 95.339 58.426 1.00 50.38 ? 111 TRP B O 1 ATOM 2917 C CB . TRP B 1 45 ? 49.885 98.312 59.201 1.00 38.60 ? 111 TRP B CB 1 ATOM 2918 C CG . TRP B 1 45 ? 50.724 97.424 60.070 1.00 38.90 ? 111 TRP B CG 1 ATOM 2919 C CD1 . TRP B 1 45 ? 50.772 97.432 61.431 1.00 41.67 ? 111 TRP B CD1 1 ATOM 2920 C CD2 . TRP B 1 45 ? 51.720 96.474 59.639 1.00 38.73 ? 111 TRP B CD2 1 ATOM 2921 N NE1 . TRP B 1 45 ? 51.727 96.542 61.880 1.00 41.15 ? 111 TRP B NE1 1 ATOM 2922 C CE2 . TRP B 1 45 ? 52.322 95.941 60.803 1.00 42.03 ? 111 TRP B CE2 1 ATOM 2923 C CE3 . TRP B 1 45 ? 52.147 96.004 58.379 1.00 39.80 ? 111 TRP B CE3 1 ATOM 2924 C CZ2 . TRP B 1 45 ? 53.320 94.967 60.751 1.00 41.27 ? 111 TRP B CZ2 1 ATOM 2925 C CZ3 . TRP B 1 45 ? 53.153 95.058 58.327 1.00 41.40 ? 111 TRP B CZ3 1 ATOM 2926 C CH2 . TRP B 1 45 ? 53.724 94.540 59.505 1.00 42.18 ? 111 TRP B CH2 1 ATOM 2927 N N . VAL B 1 46 ? 49.224 96.579 56.594 1.00 45.17 ? 112 VAL B N 1 ATOM 2928 C CA . VAL B 1 46 ? 49.625 95.493 55.695 1.00 45.28 ? 112 VAL B CA 1 ATOM 2929 C C . VAL B 1 46 ? 50.847 95.979 54.872 1.00 49.56 ? 112 VAL B C 1 ATOM 2930 O O . VAL B 1 46 ? 51.013 97.195 54.729 1.00 48.24 ? 112 VAL B O 1 ATOM 2931 C CB . VAL B 1 46 ? 48.468 95.013 54.778 1.00 49.29 ? 112 VAL B CB 1 ATOM 2932 C CG1 . VAL B 1 46 ? 47.433 94.188 55.551 1.00 48.68 ? 112 VAL B CG1 1 ATOM 2933 C CG2 . VAL B 1 46 ? 47.822 96.170 54.012 1.00 49.25 ? 112 VAL B CG2 1 ATOM 2934 N N . PRO B 1 47 ? 51.714 95.100 54.316 1.00 47.67 ? 113 PRO B N 1 ATOM 2935 C CA . PRO B 1 47 ? 52.799 95.611 53.460 1.00 48.22 ? 113 PRO B CA 1 ATOM 2936 C C . PRO B 1 47 ? 52.205 96.251 52.187 1.00 55.44 ? 113 PRO B C 1 ATOM 2937 O O . PRO B 1 47 ? 51.152 95.818 51.712 1.00 56.54 ? 113 PRO B O 1 ATOM 2938 C CB . PRO B 1 47 ? 53.629 94.349 53.147 1.00 49.53 ? 113 PRO B CB 1 ATOM 2939 C CG . PRO B 1 47 ? 53.178 93.305 54.127 1.00 53.22 ? 113 PRO B CG 1 ATOM 2940 C CD . PRO B 1 47 ? 51.726 93.622 54.342 1.00 49.15 ? 113 PRO B CD 1 ATOM 2941 N N . SER B 1 48 ? 52.815 97.341 51.696 1.00 53.00 ? 114 SER B N 1 ATOM 2942 C CA . SER B 1 48 ? 52.327 98.063 50.510 1.00 52.62 ? 114 SER B CA 1 ATOM 2943 C C . SER B 1 48 ? 53.063 97.630 49.259 1.00 56.48 ? 114 SER B C 1 ATOM 2944 O O . SER B 1 48 ? 54.176 97.128 49.368 1.00 56.80 ? 114 SER B O 1 ATOM 2945 C CB . SER B 1 48 ? 52.508 99.564 50.700 1.00 55.18 ? 114 SER B CB 1 ATOM 2946 O OG . SER B 1 48 ? 52.187 100.266 49.515 1.00 58.32 ? 114 SER B OG 1 ATOM 2947 N N . SER B 1 49 ? 52.450 97.843 48.067 1.00 53.24 ? 115 SER B N 1 ATOM 2948 C CA . SER B 1 49 ? 53.046 97.577 46.736 1.00 52.46 ? 115 SER B CA 1 ATOM 2949 C C . SER B 1 49 ? 54.201 98.570 46.497 1.00 56.14 ? 115 SER B C 1 ATOM 2950 O O . SER B 1 49 ? 55.127 98.285 45.738 1.00 55.90 ? 115 SER B O 1 ATOM 2951 C CB . SER B 1 49 ? 51.999 97.706 45.626 1.00 53.27 ? 115 SER B CB 1 ATOM 2952 O OG . SER B 1 49 ? 51.341 98.964 45.662 1.00 53.28 ? 115 SER B OG 1 ATOM 2953 N N . LYS B 1 50 ? 54.142 99.714 47.192 1.00 53.34 ? 116 LYS B N 1 ATOM 2954 C CA . LYS B 1 50 ? 55.116 100.797 47.182 1.00 53.95 ? 116 LYS B CA 1 ATOM 2955 C C . LYS B 1 50 ? 56.323 100.522 48.116 1.00 63.15 ? 116 LYS B C 1 ATOM 2956 O O . LYS B 1 50 ? 57.181 101.395 48.269 1.00 63.70 ? 116 LYS B O 1 ATOM 2957 C CB . LYS B 1 50 ? 54.427 102.134 47.496 1.00 55.01 ? 116 LYS B CB 1 ATOM 2958 C CG . LYS B 1 50 ? 53.418 102.516 46.416 1.00 65.34 ? 116 LYS B CG 1 ATOM 2959 C CD . LYS B 1 50 ? 52.435 103.595 46.847 1.00 78.27 ? 116 LYS B CD 1 ATOM 2960 C CE . LYS B 1 50 ? 51.285 103.766 45.873 1.00 95.14 ? 116 LYS B CE 1 ATOM 2961 N NZ . LYS B 1 50 ? 51.719 104.291 44.544 1.00 108.41 ? 116 LYS B NZ 1 ATOM 2962 N N . CYS B 1 51 ? 56.407 99.309 48.712 1.00 62.20 ? 117 CYS B N 1 ATOM 2963 C CA . CYS B 1 51 ? 57.525 98.938 49.569 1.00 63.80 ? 117 CYS B CA 1 ATOM 2964 C C . CYS B 1 51 ? 58.712 98.575 48.690 1.00 72.36 ? 117 CYS B C 1 ATOM 2965 O O . CYS B 1 51 ? 58.590 97.676 47.845 1.00 71.66 ? 117 CYS B O 1 ATOM 2966 C CB . CYS B 1 51 ? 57.161 97.791 50.508 1.00 64.36 ? 117 CYS B CB 1 ATOM 2967 S SG . CYS B 1 51 ? 58.529 97.225 51.557 1.00 68.57 ? 117 CYS B SG 1 ATOM 2968 N N . SER B 1 52 ? 59.877 99.242 48.919 1.00 71.77 ? 118 SER B N 1 ATOM 2969 C CA . SER B 1 52 ? 61.103 98.952 48.173 1.00 72.62 ? 118 SER B CA 1 ATOM 2970 C C . SER B 1 52 ? 61.472 97.490 48.321 1.00 77.66 ? 118 SER B C 1 ATOM 2971 O O . SER B 1 52 ? 61.529 96.985 49.443 1.00 78.40 ? 118 SER B O 1 ATOM 2972 C CB . SER B 1 52 ? 62.268 99.808 48.656 1.00 77.48 ? 118 SER B CB 1 ATOM 2973 O OG . SER B 1 52 ? 63.442 99.350 48.005 1.00 86.74 ? 118 SER B OG 1 ATOM 2974 N N . ARG B 1 53 ? 61.736 96.818 47.188 1.00 73.18 ? 119 ARG B N 1 ATOM 2975 C CA . ARG B 1 53 ? 62.103 95.402 47.133 1.00 72.32 ? 119 ARG B CA 1 ATOM 2976 C C . ARG B 1 53 ? 63.483 95.103 47.743 1.00 75.92 ? 119 ARG B C 1 ATOM 2977 O O . ARG B 1 53 ? 63.917 93.941 47.728 1.00 75.41 ? 119 ARG B O 1 ATOM 2978 C CB . ARG B 1 53 ? 61.997 94.867 45.698 1.00 72.44 ? 119 ARG B CB 1 ATOM 2979 N N . LEU B 1 54 ? 64.166 96.147 48.296 1.00 71.79 ? 120 LEU B N 1 ATOM 2980 C CA . LEU B 1 54 ? 65.462 96.000 48.967 1.00 71.66 ? 120 LEU B CA 1 ATOM 2981 C C . LEU B 1 54 ? 65.280 95.201 50.269 1.00 74.41 ? 120 LEU B C 1 ATOM 2982 O O . LEU B 1 54 ? 66.171 94.445 50.665 1.00 73.74 ? 120 LEU B O 1 ATOM 2983 C CB . LEU B 1 54 ? 66.182 97.364 49.203 1.00 71.96 ? 120 LEU B CB 1 ATOM 2984 C CG . LEU B 1 54 ? 65.576 98.429 50.167 1.00 77.04 ? 120 LEU B CG 1 ATOM 2985 C CD1 . LEU B 1 54 ? 65.975 98.177 51.627 1.00 77.25 ? 120 LEU B CD1 1 ATOM 2986 C CD2 . LEU B 1 54 ? 66.069 99.838 49.799 1.00 79.62 ? 120 LEU B CD2 1 ATOM 2987 N N . TYR B 1 55 ? 64.108 95.386 50.925 1.00 69.93 ? 121 TYR B N 1 ATOM 2988 C CA . TYR B 1 55 ? 63.712 94.681 52.129 1.00 69.01 ? 121 TYR B CA 1 ATOM 2989 C C . TYR B 1 55 ? 63.243 93.320 51.661 1.00 71.57 ? 121 TYR B C 1 ATOM 2990 O O . TYR B 1 55 ? 62.209 93.222 50.990 1.00 70.79 ? 121 TYR B O 1 ATOM 2991 C CB . TYR B 1 55 ? 62.541 95.382 52.818 1.00 70.18 ? 121 TYR B CB 1 ATOM 2992 C CG . TYR B 1 55 ? 62.779 96.819 53.212 1.00 72.78 ? 121 TYR B CG 1 ATOM 2993 C CD1 . TYR B 1 55 ? 63.449 97.137 54.393 1.00 75.15 ? 121 TYR B CD1 1 ATOM 2994 C CD2 . TYR B 1 55 ? 62.224 97.862 52.478 1.00 73.47 ? 121 TYR B CD2 1 ATOM 2995 C CE1 . TYR B 1 55 ? 63.604 98.464 54.803 1.00 76.43 ? 121 TYR B CE1 1 ATOM 2996 C CE2 . TYR B 1 55 ? 62.365 99.188 52.882 1.00 74.47 ? 121 TYR B CE2 1 ATOM 2997 C CZ . TYR B 1 55 ? 63.063 99.487 54.040 1.00 83.27 ? 121 TYR B CZ 1 ATOM 2998 O OH . TYR B 1 55 ? 63.208 100.802 54.425 1.00 85.44 ? 121 TYR B OH 1 ATOM 2999 N N . THR B 1 56 ? 64.013 92.271 51.987 1.00 67.87 ? 122 THR B N 1 ATOM 3000 C CA . THR B 1 56 ? 63.674 90.892 51.612 1.00 67.99 ? 122 THR B CA 1 ATOM 3001 C C . THR B 1 56 ? 62.296 90.495 52.187 1.00 72.15 ? 122 THR B C 1 ATOM 3002 O O . THR B 1 56 ? 61.644 89.582 51.659 1.00 71.69 ? 122 THR B O 1 ATOM 3003 C CB . THR B 1 56 ? 64.815 89.910 51.960 1.00 73.47 ? 122 THR B CB 1 ATOM 3004 O OG1 . THR B 1 56 ? 65.409 90.274 53.208 1.00 72.12 ? 122 THR B OG1 1 ATOM 3005 C CG2 . THR B 1 56 ? 65.893 89.861 50.882 1.00 71.72 ? 122 THR B CG2 1 ATOM 3006 N N . ALA B 1 57 ? 61.848 91.230 53.238 1.00 68.27 ? 123 ALA B N 1 ATOM 3007 C CA . ALA B 1 57 ? 60.567 91.054 53.899 1.00 68.03 ? 123 ALA B CA 1 ATOM 3008 C C . ALA B 1 57 ? 59.424 91.351 52.920 1.00 71.82 ? 123 ALA B C 1 ATOM 3009 O O . ALA B 1 57 ? 58.536 90.518 52.780 1.00 72.38 ? 123 ALA B O 1 ATOM 3010 C CB . ALA B 1 57 ? 60.476 91.952 55.124 1.00 68.79 ? 123 ALA B CB 1 ATOM 3011 N N . CYS B 1 58 ? 59.478 92.477 52.186 1.00 67.02 ? 124 CYS B N 1 ATOM 3012 C CA . CYS B 1 58 ? 58.418 92.814 51.235 1.00 66.00 ? 124 CYS B CA 1 ATOM 3013 C C . CYS B 1 58 ? 58.353 91.884 50.008 1.00 71.34 ? 124 CYS B C 1 ATOM 3014 O O . CYS B 1 58 ? 57.266 91.684 49.457 1.00 72.27 ? 124 CYS B O 1 ATOM 3015 C CB . CYS B 1 58 ? 58.496 94.275 50.846 1.00 65.16 ? 124 CYS B CB 1 ATOM 3016 S SG . CYS B 1 58 ? 57.985 95.378 52.182 1.00 68.64 ? 124 CYS B SG 1 ATOM 3017 N N . VAL B 1 59 ? 59.478 91.248 49.652 1.00 67.41 ? 125 VAL B N 1 ATOM 3018 C CA . VAL B 1 59 ? 59.561 90.262 48.561 1.00 67.00 ? 125 VAL B CA 1 ATOM 3019 C C . VAL B 1 59 ? 58.818 88.963 48.982 1.00 69.87 ? 125 VAL B C 1 ATOM 3020 O O . VAL B 1 59 ? 58.104 88.363 48.171 1.00 68.45 ? 125 VAL B O 1 ATOM 3021 C CB . VAL B 1 59 ? 61.047 89.996 48.177 1.00 70.73 ? 125 VAL B CB 1 ATOM 3022 C CG1 . VAL B 1 59 ? 61.179 88.878 47.144 1.00 70.55 ? 125 VAL B CG1 1 ATOM 3023 C CG2 . VAL B 1 59 ? 61.727 91.275 47.683 1.00 70.48 ? 125 VAL B CG2 1 ATOM 3024 N N . TYR B 1 60 ? 59.006 88.552 50.259 1.00 66.52 ? 126 TYR B N 1 ATOM 3025 C CA . TYR B 1 60 ? 58.433 87.359 50.894 1.00 65.76 ? 126 TYR B CA 1 ATOM 3026 C C . TYR B 1 60 ? 56.964 87.491 51.378 1.00 68.42 ? 126 TYR B C 1 ATOM 3027 O O . TYR B 1 60 ? 56.400 86.491 51.813 1.00 68.49 ? 126 TYR B O 1 ATOM 3028 C CB . TYR B 1 60 ? 59.326 86.917 52.051 1.00 66.41 ? 126 TYR B CB 1 ATOM 3029 N N . HIS B 1 61 ? 56.336 88.686 51.287 1.00 63.78 ? 127 HIS B N 1 ATOM 3030 C CA . HIS B 1 61 ? 54.968 88.906 51.756 1.00 63.55 ? 127 HIS B CA 1 ATOM 3031 C C . HIS B 1 61 ? 54.023 89.427 50.682 1.00 65.84 ? 127 HIS B C 1 ATOM 3032 O O . HIS B 1 61 ? 54.462 89.907 49.637 1.00 66.35 ? 127 HIS B O 1 ATOM 3033 C CB . HIS B 1 61 ? 54.962 89.838 52.997 1.00 64.56 ? 127 HIS B CB 1 ATOM 3034 C CG . HIS B 1 61 ? 55.513 89.175 54.217 1.00 68.02 ? 127 HIS B CG 1 ATOM 3035 N ND1 . HIS B 1 61 ? 56.822 89.356 54.609 1.00 69.98 ? 127 HIS B ND1 1 ATOM 3036 C CD2 . HIS B 1 61 ? 54.937 88.276 55.039 1.00 69.84 ? 127 HIS B CD2 1 ATOM 3037 C CE1 . HIS B 1 61 ? 56.995 88.585 55.667 1.00 69.42 ? 127 HIS B CE1 1 ATOM 3038 N NE2 . HIS B 1 61 ? 55.881 87.932 55.974 1.00 69.73 ? 127 HIS B NE2 1 ATOM 3039 N N . LYS B 1 62 ? 52.720 89.310 50.947 1.00 60.10 ? 128 LYS B N 1 ATOM 3040 C CA . LYS B 1 62 ? 51.657 89.818 50.090 1.00 58.61 ? 128 LYS B CA 1 ATOM 3041 C C . LYS B 1 62 ? 51.651 91.348 50.269 1.00 59.54 ? 128 LYS B C 1 ATOM 3042 O O . LYS B 1 62 ? 51.786 91.838 51.389 1.00 60.01 ? 128 LYS B O 1 ATOM 3043 C CB . LYS B 1 62 ? 50.305 89.177 50.495 1.00 60.26 ? 128 LYS B CB 1 ATOM 3044 C CG . LYS B 1 62 ? 49.085 89.637 49.700 1.00 63.04 ? 128 LYS B CG 1 ATOM 3045 C CD . LYS B 1 62 ? 48.946 88.941 48.378 1.00 67.91 ? 128 LYS B CD 1 ATOM 3046 C CE . LYS B 1 62 ? 47.499 88.829 47.972 1.00 73.74 ? 128 LYS B CE 1 ATOM 3047 N NZ . LYS B 1 62 ? 46.867 87.633 48.580 1.00 86.80 ? 128 LYS B NZ 1 ATOM 3048 N N . LEU B 1 63 ? 51.524 92.093 49.172 1.00 53.60 ? 129 LEU B N 1 ATOM 3049 C CA . LEU B 1 63 ? 51.526 93.555 49.222 1.00 52.54 ? 129 LEU B CA 1 ATOM 3050 C C . LEU B 1 63 ? 50.219 94.137 48.717 1.00 53.14 ? 129 LEU B C 1 ATOM 3051 O O . LEU B 1 63 ? 49.680 93.655 47.719 1.00 52.77 ? 129 LEU B O 1 ATOM 3052 C CB . LEU B 1 63 ? 52.703 94.119 48.394 1.00 53.02 ? 129 LEU B CB 1 ATOM 3053 C CG . LEU B 1 63 ? 54.075 93.445 48.550 1.00 58.27 ? 129 LEU B CG 1 ATOM 3054 C CD1 . LEU B 1 63 ? 54.977 93.751 47.366 1.00 58.89 ? 129 LEU B CD1 1 ATOM 3055 C CD2 . LEU B 1 63 ? 54.749 93.852 49.842 1.00 60.11 ? 129 LEU B CD2 1 ATOM 3056 N N . PHE B 1 64 ? 49.731 95.194 49.377 1.00 47.81 ? 130 PHE B N 1 ATOM 3057 C CA . PHE B 1 64 ? 48.508 95.875 48.970 1.00 47.89 ? 130 PHE B CA 1 ATOM 3058 C C . PHE B 1 64 ? 48.788 96.807 47.801 1.00 55.97 ? 130 PHE B C 1 ATOM 3059 O O . PHE B 1 64 ? 49.656 97.685 47.898 1.00 55.87 ? 130 PHE B O 1 ATOM 3060 C CB . PHE B 1 64 ? 47.879 96.683 50.135 1.00 48.83 ? 130 PHE B CB 1 ATOM 3061 C CG . PHE B 1 64 ? 46.640 97.469 49.749 1.00 49.23 ? 130 PHE B CG 1 ATOM 3062 C CD1 . PHE B 1 64 ? 45.437 96.819 49.474 1.00 52.19 ? 130 PHE B CD1 1 ATOM 3063 C CD2 . PHE B 1 64 ? 46.677 98.854 49.652 1.00 49.22 ? 130 PHE B CD2 1 ATOM 3064 C CE1 . PHE B 1 64 ? 44.293 97.547 49.101 1.00 52.02 ? 130 PHE B CE1 1 ATOM 3065 C CE2 . PHE B 1 64 ? 45.534 99.580 49.291 1.00 51.09 ? 130 PHE B CE2 1 ATOM 3066 C CZ . PHE B 1 64 ? 44.350 98.921 49.019 1.00 49.59 ? 130 PHE B CZ 1 ATOM 3067 N N . ASP B 1 65 ? 47.992 96.674 46.733 1.00 54.56 ? 131 ASP B N 1 ATOM 3068 C CA . ASP B 1 65 ? 48.078 97.535 45.556 1.00 54.72 ? 131 ASP B CA 1 ATOM 3069 C C . ASP B 1 65 ? 46.799 98.346 45.441 1.00 60.15 ? 131 ASP B C 1 ATOM 3070 O O . ASP B 1 65 ? 45.749 97.808 45.073 1.00 60.92 ? 131 ASP B O 1 ATOM 3071 C CB . ASP B 1 65 ? 48.370 96.725 44.272 1.00 56.91 ? 131 ASP B CB 1 ATOM 3072 C CG . ASP B 1 65 ? 49.026 97.516 43.141 1.00 66.59 ? 131 ASP B CG 1 ATOM 3073 O OD1 . ASP B 1 65 ? 48.863 98.758 43.103 1.00 66.71 ? 131 ASP B OD1 1 ATOM 3074 O OD2 . ASP B 1 65 ? 49.697 96.894 42.298 1.00 72.73 ? 131 ASP B OD2 1 ATOM 3075 N N . ALA B 1 66 ? 46.876 99.636 45.815 1.00 57.41 ? 132 ALA B N 1 ATOM 3076 C CA . ALA B 1 66 ? 45.750 100.565 45.779 1.00 57.80 ? 132 ALA B CA 1 ATOM 3077 C C . ALA B 1 66 ? 45.210 100.763 44.346 1.00 63.89 ? 132 ALA B C 1 ATOM 3078 O O . ALA B 1 66 ? 44.008 100.977 44.159 1.00 63.29 ? 132 ALA B O 1 ATOM 3079 C CB . ALA B 1 66 ? 46.170 101.894 46.385 1.00 58.50 ? 132 ALA B CB 1 ATOM 3080 N N . SER B 1 67 ? 46.110 100.650 43.343 1.00 62.17 ? 133 SER B N 1 ATOM 3081 C CA . SER B 1 67 ? 45.826 100.792 41.913 1.00 62.40 ? 133 SER B CA 1 ATOM 3082 C C . SER B 1 67 ? 44.889 99.694 41.374 1.00 67.07 ? 133 SER B C 1 ATOM 3083 O O . SER B 1 67 ? 44.396 99.819 40.255 1.00 67.49 ? 133 SER B O 1 ATOM 3084 C CB . SER B 1 67 ? 47.128 100.814 41.119 1.00 65.62 ? 133 SER B CB 1 ATOM 3085 O OG . SER B 1 67 ? 47.624 99.505 40.905 1.00 75.71 ? 133 SER B OG 1 ATOM 3086 N N . ASP B 1 68 ? 44.664 98.621 42.159 1.00 62.70 ? 134 ASP B N 1 ATOM 3087 C CA . ASP B 1 68 ? 43.774 97.521 41.797 1.00 61.70 ? 134 ASP B CA 1 ATOM 3088 C C . ASP B 1 68 ? 42.457 97.561 42.580 1.00 63.41 ? 134 ASP B C 1 ATOM 3089 O O . ASP B 1 68 ? 41.631 96.659 42.439 1.00 64.13 ? 134 ASP B O 1 ATOM 3090 C CB . ASP B 1 68 ? 44.487 96.175 41.960 1.00 63.36 ? 134 ASP B CB 1 ATOM 3091 C CG . ASP B 1 68 ? 45.669 96.001 41.036 1.00 77.05 ? 134 ASP B CG 1 ATOM 3092 O OD1 . ASP B 1 68 ? 45.673 96.629 39.948 1.00 80.21 ? 134 ASP B OD1 1 ATOM 3093 O OD2 . ASP B 1 68 ? 46.591 95.233 41.389 1.00 79.99 ? 134 ASP B OD2 1 ATOM 3094 N N . SER B 1 69 ? 42.250 98.616 43.376 1.00 57.37 ? 135 SER B N 1 ATOM 3095 C CA . SER B 1 69 ? 41.053 98.756 44.191 1.00 56.47 ? 135 SER B CA 1 ATOM 3096 C C . SER B 1 69 ? 40.243 99.994 43.840 1.00 60.81 ? 135 SER B C 1 ATOM 3097 O O . SER B 1 69 ? 40.761 101.113 43.925 1.00 60.36 ? 135 SER B O 1 ATOM 3098 C CB . SER B 1 69 ? 41.405 98.733 45.677 1.00 58.39 ? 135 SER B CB 1 ATOM 3099 O OG . SER B 1 69 ? 40.247 98.997 46.453 1.00 61.17 ? 135 SER B OG 1 ATOM 3100 N N . SER B 1 70 ? 38.959 99.783 43.465 1.00 57.82 ? 136 SER B N 1 ATOM 3101 C CA . SER B 1 70 ? 38.028 100.855 43.088 1.00 58.40 ? 136 SER B CA 1 ATOM 3102 C C . SER B 1 70 ? 37.452 101.609 44.292 1.00 63.52 ? 136 SER B C 1 ATOM 3103 O O . SER B 1 70 ? 36.973 102.737 44.148 1.00 63.86 ? 136 SER B O 1 ATOM 3104 C CB . SER B 1 70 ? 36.904 100.311 42.208 1.00 62.71 ? 136 SER B CB 1 ATOM 3105 O OG . SER B 1 70 ? 36.042 99.417 42.896 1.00 72.33 ? 136 SER B OG 1 ATOM 3106 N N . SER B 1 71 ? 37.494 100.986 45.475 1.00 60.54 ? 137 SER B N 1 ATOM 3107 C CA . SER B 1 71 ? 36.977 101.554 46.725 1.00 60.41 ? 137 SER B CA 1 ATOM 3108 C C . SER B 1 71 ? 38.035 102.294 47.549 1.00 63.52 ? 137 SER B C 1 ATOM 3109 O O . SER B 1 71 ? 37.708 102.882 48.580 1.00 62.10 ? 137 SER B O 1 ATOM 3110 C CB . SER B 1 71 ? 36.302 100.469 47.555 1.00 64.88 ? 137 SER B CB 1 ATOM 3111 O OG . SER B 1 71 ? 37.089 99.289 47.598 1.00 73.85 ? 137 SER B OG 1 ATOM 3112 N N . TYR B 1 72 ? 39.292 102.288 47.081 1.00 61.95 ? 138 TYR B N 1 ATOM 3113 C CA . TYR B 1 72 ? 40.410 102.967 47.734 1.00 63.26 ? 138 TYR B CA 1 ATOM 3114 C C . TYR B 1 72 ? 40.233 104.484 47.767 1.00 66.84 ? 138 TYR B C 1 ATOM 3115 O O . TYR B 1 72 ? 39.812 105.085 46.772 1.00 66.75 ? 138 TYR B O 1 ATOM 3116 C CB . TYR B 1 72 ? 41.733 102.572 47.056 1.00 66.07 ? 138 TYR B CB 1 ATOM 3117 C CG . TYR B 1 72 ? 42.904 103.492 47.336 1.00 71.31 ? 138 TYR B CG 1 ATOM 3118 C CD1 . TYR B 1 72 ? 43.590 103.436 48.550 1.00 74.38 ? 138 TYR B CD1 1 ATOM 3119 C CD2 . TYR B 1 72 ? 43.347 104.401 46.379 1.00 72.61 ? 138 TYR B CD2 1 ATOM 3120 C CE1 . TYR B 1 72 ? 44.680 104.270 48.806 1.00 76.60 ? 138 TYR B CE1 1 ATOM 3121 C CE2 . TYR B 1 72 ? 44.438 105.234 46.621 1.00 73.81 ? 138 TYR B CE2 1 ATOM 3122 C CZ . TYR B 1 72 ? 45.109 105.158 47.832 1.00 83.56 ? 138 TYR B CZ 1 ATOM 3123 O OH . TYR B 1 72 ? 46.187 105.983 48.068 1.00 85.02 ? 138 TYR B OH 1 ATOM 3124 N N . LYS B 1 73 ? 40.539 105.089 48.925 1.00 63.40 ? 139 LYS B N 1 ATOM 3125 C CA . LYS B 1 73 ? 40.508 106.545 49.129 1.00 63.23 ? 139 LYS B CA 1 ATOM 3126 C C . LYS B 1 73 ? 41.871 106.957 49.677 1.00 69.38 ? 139 LYS B C 1 ATOM 3127 O O . LYS B 1 73 ? 42.288 106.484 50.740 1.00 68.73 ? 139 LYS B O 1 ATOM 3128 C CB . LYS B 1 73 ? 39.363 107.005 50.057 1.00 64.59 ? 139 LYS B CB 1 ATOM 3129 N N . HIS B 1 74 ? 42.579 107.806 48.922 1.00 67.32 ? 140 HIS B N 1 ATOM 3130 C CA . HIS B 1 74 ? 43.912 108.281 49.267 1.00 67.29 ? 140 HIS B CA 1 ATOM 3131 C C . HIS B 1 74 ? 43.948 109.117 50.554 1.00 69.58 ? 140 HIS B C 1 ATOM 3132 O O . HIS B 1 74 ? 43.012 109.875 50.830 1.00 67.77 ? 140 HIS B O 1 ATOM 3133 C CB . HIS B 1 74 ? 44.511 109.079 48.077 1.00 68.28 ? 140 HIS B CB 1 ATOM 3134 C CG . HIS B 1 74 ? 45.814 109.766 48.383 1.00 71.80 ? 140 HIS B CG 1 ATOM 3135 N ND1 . HIS B 1 74 ? 47.001 109.047 48.450 1.00 73.71 ? 140 HIS B ND1 1 ATOM 3136 C CD2 . HIS B 1 74 ? 46.084 111.068 48.632 1.00 73.14 ? 140 HIS B CD2 1 ATOM 3137 C CE1 . HIS B 1 74 ? 47.940 109.924 48.766 1.00 72.83 ? 140 HIS B CE1 1 ATOM 3138 N NE2 . HIS B 1 74 ? 47.442 111.150 48.883 1.00 73.02 ? 140 HIS B NE2 1 ATOM 3139 N N . ASN B 1 75 ? 45.033 108.973 51.335 1.00 66.48 ? 141 ASN B N 1 ATOM 3140 C CA . ASN B 1 75 ? 45.279 109.805 52.502 1.00 67.07 ? 141 ASN B CA 1 ATOM 3141 C C . ASN B 1 75 ? 46.717 110.290 52.445 1.00 72.80 ? 141 ASN B C 1 ATOM 3142 O O . ASN B 1 75 ? 46.942 111.463 52.175 1.00 74.03 ? 141 ASN B O 1 ATOM 3143 C CB . ASN B 1 75 ? 44.873 109.174 53.836 1.00 67.69 ? 141 ASN B CB 1 ATOM 3144 C CG . ASN B 1 75 ? 44.971 110.177 54.951 1.00 97.12 ? 141 ASN B CG 1 ATOM 3145 O OD1 . ASN B 1 75 ? 46.049 110.387 55.512 1.00 81.96 ? 141 ASN B OD1 1 ATOM 3146 N ND2 . ASN B 1 75 ? 43.852 110.840 55.247 1.00 104.30 ? 141 ASN B ND2 1 ATOM 3147 N N . GLY B 1 76 ? 47.669 109.387 52.606 1.00 69.11 ? 142 GLY B N 1 ATOM 3148 C CA . GLY B 1 76 ? 49.078 109.720 52.458 1.00 68.64 ? 142 GLY B CA 1 ATOM 3149 C C . GLY B 1 76 ? 49.846 110.155 53.687 1.00 72.11 ? 142 GLY B C 1 ATOM 3150 O O . GLY B 1 76 ? 51.077 110.235 53.615 1.00 71.30 ? 142 GLY B O 1 ATOM 3151 N N . THR B 1 77 ? 49.144 110.436 54.822 1.00 68.24 ? 143 THR B N 1 ATOM 3152 C CA . THR B 1 77 ? 49.777 110.835 56.090 1.00 67.49 ? 143 THR B CA 1 ATOM 3153 C C . THR B 1 77 ? 50.794 109.782 56.527 1.00 72.09 ? 143 THR B C 1 ATOM 3154 O O . THR B 1 77 ? 50.472 108.595 56.563 1.00 71.61 ? 143 THR B O 1 ATOM 3155 C CB . THR B 1 77 ? 48.730 111.078 57.181 1.00 71.54 ? 143 THR B CB 1 ATOM 3156 O OG1 . THR B 1 77 ? 47.794 112.062 56.737 1.00 71.63 ? 143 THR B OG1 1 ATOM 3157 C CG2 . THR B 1 77 ? 49.346 111.508 58.504 1.00 69.76 ? 143 THR B CG2 1 ATOM 3158 N N . GLU B 1 78 ? 52.026 110.226 56.842 1.00 68.62 ? 144 GLU B N 1 ATOM 3159 C CA . GLU B 1 78 ? 53.114 109.366 57.301 1.00 67.84 ? 144 GLU B CA 1 ATOM 3160 C C . GLU B 1 78 ? 52.713 108.677 58.597 1.00 70.01 ? 144 GLU B C 1 ATOM 3161 O O . GLU B 1 78 ? 51.957 109.236 59.398 1.00 69.11 ? 144 GLU B O 1 ATOM 3162 C CB . GLU B 1 78 ? 54.396 110.178 57.508 1.00 69.32 ? 144 GLU B CB 1 ATOM 3163 N N . LEU B 1 79 ? 53.204 107.451 58.791 1.00 65.61 ? 145 LEU B N 1 ATOM 3164 C CA . LEU B 1 79 ? 52.880 106.645 59.955 1.00 64.47 ? 145 LEU B CA 1 ATOM 3165 C C . LEU B 1 79 ? 54.080 105.811 60.337 1.00 66.45 ? 145 LEU B C 1 ATOM 3166 O O . LEU B 1 79 ? 54.651 105.134 59.484 1.00 66.30 ? 145 LEU B O 1 ATOM 3167 C CB . LEU B 1 79 ? 51.636 105.781 59.619 1.00 64.58 ? 145 LEU B CB 1 ATOM 3168 C CG . LEU B 1 79 ? 51.089 104.759 60.605 1.00 69.28 ? 145 LEU B CG 1 ATOM 3169 C CD1 . LEU B 1 79 ? 51.416 103.390 60.228 1.00 69.64 ? 145 LEU B CD1 1 ATOM 3170 C CD2 . LEU B 1 79 ? 51.043 105.193 62.047 1.00 71.78 ? 145 LEU B CD2 1 ATOM 3171 N N . THR B 1 80 ? 54.476 105.886 61.618 1.00 62.03 ? 146 THR B N 1 ATOM 3172 C CA . THR B 1 80 ? 55.574 105.091 62.180 1.00 61.31 ? 146 THR B CA 1 ATOM 3173 C C . THR B 1 80 ? 55.017 104.292 63.360 1.00 63.15 ? 146 THR B C 1 ATOM 3174 O O . THR B 1 80 ? 54.387 104.856 64.257 1.00 61.35 ? 146 THR B O 1 ATOM 3175 C CB . THR B 1 80 ? 56.805 105.963 62.541 1.00 70.14 ? 146 THR B CB 1 ATOM 3176 O OG1 . THR B 1 80 ? 57.269 106.634 61.368 1.00 72.54 ? 146 THR B OG1 1 ATOM 3177 C CG2 . THR B 1 80 ? 57.959 105.142 63.129 1.00 65.14 ? 146 THR B CG2 1 ATOM 3178 N N . LEU B 1 81 ? 55.254 102.981 63.353 1.00 59.19 ? 147 LEU B N 1 ATOM 3179 C CA . LEU B 1 81 ? 54.803 102.090 64.418 1.00 57.99 ? 147 LEU B CA 1 ATOM 3180 C C . LEU B 1 81 ? 56.013 101.484 65.087 1.00 60.15 ? 147 LEU B C 1 ATOM 3181 O O . LEU B 1 81 ? 56.690 100.629 64.505 1.00 58.20 ? 147 LEU B O 1 ATOM 3182 C CB . LEU B 1 81 ? 53.822 101.013 63.895 1.00 57.68 ? 147 LEU B CB 1 ATOM 3183 C CG . LEU B 1 81 ? 52.560 101.534 63.212 1.00 61.81 ? 147 LEU B CG 1 ATOM 3184 C CD1 . LEU B 1 81 ? 52.007 100.521 62.270 1.00 61.93 ? 147 LEU B CD1 1 ATOM 3185 C CD2 . LEU B 1 81 ? 51.513 101.960 64.210 1.00 64.15 ? 147 LEU B CD2 1 ATOM 3186 N N . ARG B 1 82 ? 56.336 102.001 66.286 1.00 57.80 ? 148 ARG B N 1 ATOM 3187 C CA . ARG B 1 82 ? 57.465 101.512 67.067 1.00 57.92 ? 148 ARG B CA 1 ATOM 3188 C C . ARG B 1 82 ? 56.956 100.477 68.061 1.00 61.45 ? 148 ARG B C 1 ATOM 3189 O O . ARG B 1 82 ? 56.247 100.825 69.010 1.00 62.88 ? 148 ARG B O 1 ATOM 3190 C CB . ARG B 1 82 ? 58.207 102.664 67.767 1.00 57.69 ? 148 ARG B CB 1 ATOM 3191 N N . TYR B 1 83 ? 57.260 99.207 67.799 1.00 54.87 ? 149 TYR B N 1 ATOM 3192 C CA . TYR B 1 83 ? 56.843 98.086 68.635 1.00 53.91 ? 149 TYR B CA 1 ATOM 3193 C C . TYR B 1 83 ? 58.022 97.573 69.439 1.00 59.42 ? 149 TYR B C 1 ATOM 3194 O O . TYR B 1 83 ? 59.164 97.934 69.159 1.00 58.54 ? 149 TYR B O 1 ATOM 3195 C CB . TYR B 1 83 ? 56.330 96.922 67.752 1.00 53.44 ? 149 TYR B CB 1 ATOM 3196 C CG . TYR B 1 83 ? 55.154 97.227 66.850 1.00 52.43 ? 149 TYR B CG 1 ATOM 3197 C CD1 . TYR B 1 83 ? 53.949 97.695 67.375 1.00 54.37 ? 149 TYR B CD1 1 ATOM 3198 C CD2 . TYR B 1 83 ? 55.200 96.929 65.491 1.00 51.82 ? 149 TYR B CD2 1 ATOM 3199 C CE1 . TYR B 1 83 ? 52.842 97.927 66.560 1.00 55.44 ? 149 TYR B CE1 1 ATOM 3200 C CE2 . TYR B 1 83 ? 54.096 97.148 64.664 1.00 52.16 ? 149 TYR B CE2 1 ATOM 3201 C CZ . TYR B 1 83 ? 52.918 97.651 65.202 1.00 59.08 ? 149 TYR B CZ 1 ATOM 3202 O OH . TYR B 1 83 ? 51.807 97.852 64.414 1.00 54.06 ? 149 TYR B OH 1 ATOM 3203 N N . SER B 1 84 ? 57.744 96.647 70.374 1.00 58.09 ? 150 SER B N 1 ATOM 3204 C CA . SER B 1 84 ? 58.738 95.973 71.214 1.00 59.12 ? 150 SER B CA 1 ATOM 3205 C C . SER B 1 84 ? 59.682 95.094 70.384 1.00 64.60 ? 150 SER B C 1 ATOM 3206 O O . SER B 1 84 ? 60.831 94.889 70.774 1.00 65.23 ? 150 SER B O 1 ATOM 3207 C CB . SER B 1 84 ? 58.050 95.096 72.263 1.00 62.75 ? 150 SER B CB 1 ATOM 3208 O OG . SER B 1 84 ? 57.048 95.795 72.978 1.00 73.50 ? 150 SER B OG 1 ATOM 3209 N N . THR B 1 85 ? 59.185 94.554 69.264 1.00 60.59 ? 151 THR B N 1 ATOM 3210 C CA . THR B 1 85 ? 59.943 93.648 68.404 1.00 60.43 ? 151 THR B CA 1 ATOM 3211 C C . THR B 1 85 ? 60.675 94.344 67.259 1.00 63.88 ? 151 THR B C 1 ATOM 3212 O O . THR B 1 85 ? 61.555 93.743 66.637 1.00 63.08 ? 151 THR B O 1 ATOM 3213 C CB . THR B 1 85 ? 59.034 92.536 67.889 1.00 69.52 ? 151 THR B CB 1 ATOM 3214 O OG1 . THR B 1 85 ? 57.880 93.117 67.279 1.00 68.97 ? 151 THR B OG1 1 ATOM 3215 C CG2 . THR B 1 85 ? 58.637 91.569 68.974 1.00 71.32 ? 151 THR B CG2 1 ATOM 3216 N N . GLY B 1 86 ? 60.290 95.582 66.979 1.00 60.27 ? 152 GLY B N 1 ATOM 3217 C CA . GLY B 1 86 ? 60.860 96.372 65.898 1.00 59.78 ? 152 GLY B CA 1 ATOM 3218 C C . GLY B 1 86 ? 59.980 97.530 65.491 1.00 62.51 ? 152 GLY B C 1 ATOM 3219 O O . GLY B 1 86 ? 58.963 97.799 66.135 1.00 62.50 ? 152 GLY B O 1 ATOM 3220 N N . THR B 1 87 ? 60.389 98.237 64.424 1.00 57.43 ? 153 THR B N 1 ATOM 3221 C CA . THR B 1 87 ? 59.689 99.401 63.879 1.00 55.86 ? 153 THR B CA 1 ATOM 3222 C C . THR B 1 87 ? 59.309 99.167 62.441 1.00 57.03 ? 153 THR B C 1 ATOM 3223 O O . THR B 1 87 ? 59.998 98.470 61.698 1.00 57.00 ? 153 THR B O 1 ATOM 3224 C CB . THR B 1 87 ? 60.527 100.663 64.072 1.00 63.23 ? 153 THR B CB 1 ATOM 3225 O OG1 . THR B 1 87 ? 60.792 100.775 65.466 1.00 66.14 ? 153 THR B OG1 1 ATOM 3226 C CG2 . THR B 1 87 ? 59.819 101.942 63.579 1.00 59.37 ? 153 THR B CG2 1 ATOM 3227 N N . VAL B 1 88 ? 58.222 99.796 62.053 1.00 52.23 ? 154 VAL B N 1 ATOM 3228 C CA . VAL B 1 88 ? 57.636 99.719 60.732 1.00 51.44 ? 154 VAL B CA 1 ATOM 3229 C C . VAL B 1 88 ? 57.090 101.112 60.439 1.00 54.64 ? 154 VAL B C 1 ATOM 3230 O O . VAL B 1 88 ? 56.660 101.817 61.354 1.00 54.42 ? 154 VAL B O 1 ATOM 3231 C CB . VAL B 1 88 ? 56.572 98.572 60.724 1.00 54.80 ? 154 VAL B CB 1 ATOM 3232 C CG1 . VAL B 1 88 ? 55.147 99.080 60.568 1.00 54.36 ? 154 VAL B CG1 1 ATOM 3233 C CG2 . VAL B 1 88 ? 56.913 97.498 59.695 1.00 54.41 ? 154 VAL B CG2 1 ATOM 3234 N N . SER B 1 89 ? 57.202 101.551 59.190 1.00 50.51 ? 155 SER B N 1 ATOM 3235 C CA . SER B 1 89 ? 56.735 102.878 58.791 1.00 48.83 ? 155 SER B CA 1 ATOM 3236 C C . SER B 1 89 ? 56.167 102.818 57.396 1.00 50.62 ? 155 SER B C 1 ATOM 3237 O O . SER B 1 89 ? 56.503 101.921 56.614 1.00 51.38 ? 155 SER B O 1 ATOM 3238 C CB . SER B 1 89 ? 57.849 103.924 58.906 1.00 51.12 ? 155 SER B CB 1 ATOM 3239 O OG . SER B 1 89 ? 58.982 103.633 58.098 1.00 54.41 ? 155 SER B OG 1 ATOM 3240 N N . GLY B 1 90 ? 55.288 103.753 57.110 1.00 45.19 ? 156 GLY B N 1 ATOM 3241 C CA . GLY B 1 90 ? 54.618 103.869 55.826 1.00 44.83 ? 156 GLY B CA 1 ATOM 3242 C C . GLY B 1 90 ? 53.677 105.042 55.856 1.00 49.71 ? 156 GLY B C 1 ATOM 3243 O O . GLY B 1 90 ? 53.996 106.068 56.455 1.00 49.86 ? 156 GLY B O 1 ATOM 3244 N N . PHE B 1 91 ? 52.504 104.893 55.236 1.00 47.43 ? 157 PHE B N 1 ATOM 3245 C CA . PHE B 1 91 ? 51.504 105.964 55.143 1.00 47.09 ? 157 PHE B CA 1 ATOM 3246 C C . PHE B 1 91 ? 50.069 105.432 55.288 1.00 52.27 ? 157 PHE B C 1 ATOM 3247 O O . PHE B 1 91 ? 49.816 104.256 55.047 1.00 50.00 ? 157 PHE B O 1 ATOM 3248 C CB . PHE B 1 91 ? 51.672 106.741 53.805 1.00 47.83 ? 157 PHE B CB 1 ATOM 3249 C CG . PHE B 1 91 ? 51.536 105.876 52.568 1.00 48.35 ? 157 PHE B CG 1 ATOM 3250 C CD1 . PHE B 1 91 ? 52.613 105.129 52.095 1.00 51.14 ? 157 PHE B CD1 1 ATOM 3251 C CD2 . PHE B 1 91 ? 50.324 105.784 51.893 1.00 49.67 ? 157 PHE B CD2 1 ATOM 3252 C CE1 . PHE B 1 91 ? 52.473 104.282 50.989 1.00 51.93 ? 157 PHE B CE1 1 ATOM 3253 C CE2 . PHE B 1 91 ? 50.188 104.951 50.774 1.00 52.19 ? 157 PHE B CE2 1 ATOM 3254 C CZ . PHE B 1 91 ? 51.263 104.206 50.326 1.00 50.30 ? 157 PHE B CZ 1 ATOM 3255 N N . LEU B 1 92 ? 49.137 106.327 55.632 1.00 51.62 ? 158 LEU B N 1 ATOM 3256 C CA . LEU B 1 92 ? 47.718 106.051 55.813 1.00 52.70 ? 158 LEU B CA 1 ATOM 3257 C C . LEU B 1 92 ? 46.961 105.951 54.486 1.00 59.72 ? 158 LEU B C 1 ATOM 3258 O O . LEU B 1 92 ? 47.182 106.755 53.580 1.00 61.51 ? 158 LEU B O 1 ATOM 3259 C CB . LEU B 1 92 ? 47.109 107.170 56.673 1.00 52.97 ? 158 LEU B CB 1 ATOM 3260 C CG . LEU B 1 92 ? 46.865 106.917 58.178 1.00 58.26 ? 158 LEU B CG 1 ATOM 3261 C CD1 . LEU B 1 92 ? 47.781 105.835 58.762 1.00 58.72 ? 158 LEU B CD1 1 ATOM 3262 C CD2 . LEU B 1 92 ? 46.957 108.204 58.972 1.00 59.40 ? 158 LEU B CD2 1 ATOM 3263 N N . SER B 1 93 ? 46.061 104.960 54.384 1.00 55.58 ? 159 SER B N 1 ATOM 3264 C CA . SER B 1 93 ? 45.181 104.723 53.236 1.00 54.46 ? 159 SER B CA 1 ATOM 3265 C C . SER B 1 93 ? 43.822 104.305 53.760 1.00 57.82 ? 159 SER B C 1 ATOM 3266 O O . SER B 1 93 ? 43.723 103.837 54.895 1.00 58.37 ? 159 SER B O 1 ATOM 3267 C CB . SER B 1 93 ? 45.747 103.638 52.325 1.00 56.50 ? 159 SER B CB 1 ATOM 3268 O OG . SER B 1 93 ? 46.868 104.130 51.613 1.00 61.37 ? 159 SER B OG 1 ATOM 3269 N N . GLN B 1 94 ? 42.772 104.482 52.959 1.00 52.09 ? 160 GLN B N 1 ATOM 3270 C CA . GLN B 1 94 ? 41.434 104.071 53.369 1.00 50.60 ? 160 GLN B CA 1 ATOM 3271 C C . GLN B 1 94 ? 40.851 103.146 52.332 1.00 54.51 ? 160 GLN B C 1 ATOM 3272 O O . GLN B 1 94 ? 40.985 103.393 51.132 1.00 54.59 ? 160 GLN B O 1 ATOM 3273 C CB . GLN B 1 94 ? 40.492 105.265 53.619 1.00 50.71 ? 160 GLN B CB 1 ATOM 3274 C CG . GLN B 1 94 ? 39.109 104.845 54.098 1.00 50.09 ? 160 GLN B CG 1 ATOM 3275 C CD . GLN B 1 94 ? 38.139 105.973 54.109 1.00 65.80 ? 160 GLN B CD 1 ATOM 3276 O OE1 . GLN B 1 94 ? 37.391 106.204 53.153 1.00 62.64 ? 160 GLN B OE1 1 ATOM 3277 N NE2 . GLN B 1 94 ? 38.078 106.662 55.222 1.00 61.61 ? 160 GLN B NE2 1 ATOM 3278 N N . ASP B 1 95 ? 40.212 102.068 52.797 1.00 49.93 ? 161 ASP B N 1 ATOM 3279 C CA . ASP B 1 95 ? 39.555 101.115 51.922 1.00 49.00 ? 161 ASP B CA 1 ATOM 3280 C C . ASP B 1 95 ? 38.574 100.282 52.727 1.00 52.73 ? 161 ASP B C 1 ATOM 3281 O O . ASP B 1 95 ? 38.484 100.436 53.949 1.00 51.40 ? 161 ASP B O 1 ATOM 3282 C CB . ASP B 1 95 ? 40.577 100.229 51.184 1.00 49.97 ? 161 ASP B CB 1 ATOM 3283 C CG . ASP B 1 95 ? 40.167 99.866 49.766 1.00 54.23 ? 161 ASP B CG 1 ATOM 3284 O OD1 . ASP B 1 95 ? 38.956 99.673 49.524 1.00 53.53 ? 161 ASP B OD1 1 ATOM 3285 O OD2 . ASP B 1 95 ? 41.060 99.695 48.921 1.00 58.81 ? 161 ASP B OD2 1 ATOM 3286 N N . ILE B 1 96 ? 37.813 99.430 52.037 1.00 49.23 ? 162 ILE B N 1 ATOM 3287 C CA . ILE B 1 96 ? 36.873 98.526 52.662 1.00 49.84 ? 162 ILE B CA 1 ATOM 3288 C C . ILE B 1 96 ? 37.637 97.268 53.089 1.00 52.60 ? 162 ILE B C 1 ATOM 3289 O O . ILE B 1 96 ? 38.395 96.698 52.298 1.00 51.75 ? 162 ILE B O 1 ATOM 3290 C CB . ILE B 1 96 ? 35.678 98.234 51.730 1.00 54.30 ? 162 ILE B CB 1 ATOM 3291 C CG1 . ILE B 1 96 ? 34.880 99.515 51.474 1.00 55.55 ? 162 ILE B CG1 1 ATOM 3292 C CG2 . ILE B 1 96 ? 34.767 97.155 52.309 1.00 56.66 ? 162 ILE B CG2 1 ATOM 3293 C CD1 . ILE B 1 96 ? 34.098 99.518 50.170 1.00 68.95 ? 162 ILE B CD1 1 ATOM 3294 N N . ILE B 1 97 ? 37.476 96.880 54.364 1.00 47.34 ? 163 ILE B N 1 ATOM 3295 C CA . ILE B 1 97 ? 38.091 95.682 54.931 1.00 45.76 ? 163 ILE B CA 1 ATOM 3296 C C . ILE B 1 97 ? 36.997 94.657 55.267 1.00 50.65 ? 163 ILE B C 1 ATOM 3297 O O . ILE B 1 97 ? 35.976 95.008 55.868 1.00 49.05 ? 163 ILE B O 1 ATOM 3298 C CB . ILE B 1 97 ? 39.037 95.983 56.127 1.00 47.15 ? 163 ILE B CB 1 ATOM 3299 C CG1 . ILE B 1 97 ? 40.222 96.906 55.684 1.00 46.47 ? 163 ILE B CG1 1 ATOM 3300 C CG2 . ILE B 1 97 ? 39.533 94.670 56.775 1.00 46.47 ? 163 ILE B CG2 1 ATOM 3301 C CD1 . ILE B 1 97 ? 41.327 97.208 56.758 1.00 45.28 ? 163 ILE B CD1 1 ATOM 3302 N N . THR B 1 98 ? 37.196 93.405 54.846 1.00 48.38 ? 164 THR B N 1 ATOM 3303 C CA . THR B 1 98 ? 36.262 92.326 55.147 1.00 48.14 ? 164 THR B CA 1 ATOM 3304 C C . THR B 1 98 ? 36.917 91.435 56.206 1.00 47.57 ? 164 THR B C 1 ATOM 3305 O O . THR B 1 98 ? 38.009 90.923 55.968 1.00 45.98 ? 164 THR B O 1 ATOM 3306 C CB . THR B 1 98 ? 35.683 91.586 53.881 1.00 60.38 ? 164 THR B CB 1 ATOM 3307 O OG1 . THR B 1 98 ? 35.665 90.183 54.112 1.00 68.96 ? 164 THR B OG1 1 ATOM 3308 C CG2 . THR B 1 98 ? 36.441 91.846 52.616 1.00 58.05 ? 164 THR B CG2 1 ATOM 3309 N N . VAL B 1 99 ? 36.252 91.281 57.364 1.00 42.69 ? 165 VAL B N 1 ATOM 3310 C CA . VAL B 1 99 ? 36.662 90.449 58.502 1.00 42.66 ? 165 VAL B CA 1 ATOM 3311 C C . VAL B 1 99 ? 35.477 89.474 58.735 1.00 46.32 ? 165 VAL B C 1 ATOM 3312 O O . VAL B 1 99 ? 34.425 89.912 59.213 1.00 46.17 ? 165 VAL B O 1 ATOM 3313 C CB . VAL B 1 99 ? 36.950 91.296 59.781 1.00 46.44 ? 165 VAL B CB 1 ATOM 3314 C CG1 . VAL B 1 99 ? 37.515 90.430 60.896 1.00 46.32 ? 165 VAL B CG1 1 ATOM 3315 C CG2 . VAL B 1 99 ? 37.893 92.445 59.489 1.00 46.45 ? 165 VAL B CG2 1 ATOM 3316 N N . GLY B 1 100 ? 35.642 88.209 58.335 1.00 42.18 ? 166 GLY B N 1 ATOM 3317 C CA . GLY B 1 100 ? 34.606 87.186 58.461 1.00 42.83 ? 166 GLY B CA 1 ATOM 3318 C C . GLY B 1 100 ? 33.364 87.542 57.678 1.00 51.12 ? 166 GLY B C 1 ATOM 3319 O O . GLY B 1 100 ? 33.411 87.582 56.442 1.00 52.93 ? 166 GLY B O 1 ATOM 3320 N N . GLY B 1 101 ? 32.285 87.896 58.343 1.00 48.93 ? 167 GLY B N 1 ATOM 3321 C CA . GLY B 1 101 ? 31.095 88.295 57.589 1.00 49.96 ? 167 GLY B CA 1 ATOM 3322 C C . GLY B 1 101 ? 30.772 89.781 57.611 1.00 53.92 ? 167 GLY B C 1 ATOM 3323 O O . GLY B 1 101 ? 29.652 90.175 57.265 1.00 54.04 ? 167 GLY B O 1 ATOM 3324 N N . ILE B 1 102 ? 31.751 90.615 58.000 1.00 49.50 ? 168 ILE B N 1 ATOM 3325 C CA . ILE B 1 102 ? 31.563 92.052 58.202 1.00 48.83 ? 168 ILE B CA 1 ATOM 3326 C C . ILE B 1 102 ? 32.425 92.848 57.234 1.00 53.57 ? 168 ILE B C 1 ATOM 3327 O O . ILE B 1 102 ? 33.592 92.509 57.037 1.00 52.30 ? 168 ILE B O 1 ATOM 3328 C CB . ILE B 1 102 ? 31.911 92.408 59.699 1.00 51.42 ? 168 ILE B CB 1 ATOM 3329 C CG1 . ILE B 1 102 ? 31.019 91.633 60.685 1.00 51.36 ? 168 ILE B CG1 1 ATOM 3330 C CG2 . ILE B 1 102 ? 31.853 93.919 59.974 1.00 52.00 ? 168 ILE B CG2 1 ATOM 3331 C CD1 . ILE B 1 102 ? 31.397 91.797 62.152 1.00 61.56 ? 168 ILE B CD1 1 ATOM 3332 N N . THR B 1 103 ? 31.856 93.896 56.643 1.00 51.38 ? 169 THR B N 1 ATOM 3333 C CA . THR B 1 103 ? 32.576 94.820 55.780 1.00 51.22 ? 169 THR B CA 1 ATOM 3334 C C . THR B 1 103 ? 32.589 96.150 56.522 1.00 53.71 ? 169 THR B C 1 ATOM 3335 O O . THR B 1 103 ? 31.542 96.614 56.979 1.00 53.20 ? 169 THR B O 1 ATOM 3336 C CB . THR B 1 103 ? 31.953 94.943 54.375 1.00 62.80 ? 169 THR B CB 1 ATOM 3337 O OG1 . THR B 1 103 ? 30.581 95.316 54.476 1.00 73.96 ? 169 THR B OG1 1 ATOM 3338 C CG2 . THR B 1 103 ? 32.159 93.700 53.520 1.00 56.82 ? 169 THR B CG2 1 ATOM 3339 N N . VAL B 1 104 ? 33.777 96.736 56.675 1.00 49.30 ? 170 VAL B N 1 ATOM 3340 C CA . VAL B 1 104 ? 33.962 98.023 57.346 1.00 48.15 ? 170 VAL B CA 1 ATOM 3341 C C . VAL B 1 104 ? 34.923 98.930 56.556 1.00 51.16 ? 170 VAL B C 1 ATOM 3342 O O . VAL B 1 104 ? 35.927 98.445 56.031 1.00 50.99 ? 170 VAL B O 1 ATOM 3343 C CB . VAL B 1 104 ? 34.390 97.836 58.834 1.00 51.02 ? 170 VAL B CB 1 ATOM 3344 C CG1 . VAL B 1 104 ? 35.733 97.120 58.959 1.00 50.40 ? 170 VAL B CG1 1 ATOM 3345 C CG2 . VAL B 1 104 ? 34.396 99.160 59.606 1.00 50.55 ? 170 VAL B CG2 1 ATOM 3346 N N . THR B 1 105 ? 34.598 100.231 56.455 1.00 47.33 ? 171 THR B N 1 ATOM 3347 C CA . THR B 1 105 ? 35.457 101.224 55.817 1.00 46.67 ? 171 THR B CA 1 ATOM 3348 C C . THR B 1 105 ? 36.512 101.535 56.862 1.00 48.30 ? 171 THR B C 1 ATOM 3349 O O . THR B 1 105 ? 36.165 101.923 57.983 1.00 47.35 ? 171 THR B O 1 ATOM 3350 C CB . THR B 1 105 ? 34.636 102.431 55.352 1.00 56.59 ? 171 THR B CB 1 ATOM 3351 O OG1 . THR B 1 105 ? 33.789 101.994 54.288 1.00 60.52 ? 171 THR B OG1 1 ATOM 3352 C CG2 . THR B 1 105 ? 35.517 103.570 54.870 1.00 53.65 ? 171 THR B CG2 1 ATOM 3353 N N . GLN B 1 106 ? 37.787 101.303 56.525 1.00 44.32 ? 172 GLN B N 1 ATOM 3354 C CA . GLN B 1 106 ? 38.855 101.430 57.504 1.00 44.40 ? 172 GLN B CA 1 ATOM 3355 C C . GLN B 1 106 ? 40.078 102.215 57.052 1.00 50.06 ? 172 GLN B C 1 ATOM 3356 O O . GLN B 1 106 ? 40.579 102.017 55.949 1.00 50.43 ? 172 GLN B O 1 ATOM 3357 C CB . GLN B 1 106 ? 39.275 100.001 57.953 1.00 45.29 ? 172 GLN B CB 1 ATOM 3358 C CG . GLN B 1 106 ? 40.246 99.910 59.137 1.00 47.54 ? 172 GLN B CG 1 ATOM 3359 C CD . GLN B 1 106 ? 39.679 100.515 60.398 1.00 55.36 ? 172 GLN B CD 1 ATOM 3360 O OE1 . GLN B 1 106 ? 38.484 100.387 60.706 1.00 47.05 ? 172 GLN B OE1 1 ATOM 3361 N NE2 . GLN B 1 106 ? 40.522 101.199 61.150 1.00 42.53 ? 172 GLN B NE2 1 ATOM 3362 N N . MET B 1 107 ? 40.610 103.039 57.962 1.00 47.74 ? 173 MET B N 1 ATOM 3363 C CA . MET B 1 107 ? 41.858 103.747 57.738 1.00 47.93 ? 173 MET B CA 1 ATOM 3364 C C . MET B 1 107 ? 42.957 102.808 58.266 1.00 49.72 ? 173 MET B C 1 ATOM 3365 O O . MET B 1 107 ? 42.926 102.347 59.426 1.00 47.85 ? 173 MET B O 1 ATOM 3366 C CB . MET B 1 107 ? 41.881 105.114 58.435 1.00 51.14 ? 173 MET B CB 1 ATOM 3367 C CG . MET B 1 107 ? 43.073 105.976 58.036 1.00 56.82 ? 173 MET B CG 1 ATOM 3368 S SD . MET B 1 107 ? 42.995 106.680 56.341 1.00 63.13 ? 173 MET B SD 1 ATOM 3369 C CE . MET B 1 107 ? 41.582 107.818 56.511 1.00 59.48 ? 173 MET B CE 1 ATOM 3370 N N . PHE B 1 108 ? 43.875 102.462 57.377 1.00 44.83 ? 174 PHE B N 1 ATOM 3371 C CA . PHE B 1 108 ? 44.938 101.537 57.709 1.00 44.39 ? 174 PHE B CA 1 ATOM 3372 C C . PHE B 1 108 ? 46.267 102.068 57.180 1.00 51.05 ? 174 PHE B C 1 ATOM 3373 O O . PHE B 1 108 ? 46.285 102.985 56.355 1.00 50.60 ? 174 PHE B O 1 ATOM 3374 C CB . PHE B 1 108 ? 44.613 100.132 57.136 1.00 45.17 ? 174 PHE B CB 1 ATOM 3375 C CG . PHE B 1 108 ? 44.613 100.023 55.625 1.00 45.07 ? 174 PHE B CG 1 ATOM 3376 C CD1 . PHE B 1 108 ? 43.496 100.379 54.886 1.00 46.99 ? 174 PHE B CD1 1 ATOM 3377 C CD2 . PHE B 1 108 ? 45.728 99.545 54.946 1.00 46.28 ? 174 PHE B CD2 1 ATOM 3378 C CE1 . PHE B 1 108 ? 43.501 100.275 53.492 1.00 47.64 ? 174 PHE B CE1 1 ATOM 3379 C CE2 . PHE B 1 108 ? 45.737 99.460 53.550 1.00 48.53 ? 174 PHE B CE2 1 ATOM 3380 C CZ . PHE B 1 108 ? 44.620 99.817 52.835 1.00 46.10 ? 174 PHE B CZ 1 ATOM 3381 N N . GLY B 1 109 ? 47.352 101.476 57.654 1.00 48.31 ? 175 GLY B N 1 ATOM 3382 C CA . GLY B 1 109 ? 48.691 101.814 57.230 1.00 48.41 ? 175 GLY B CA 1 ATOM 3383 C C . GLY B 1 109 ? 49.182 100.896 56.137 1.00 54.95 ? 175 GLY B C 1 ATOM 3384 O O . GLY B 1 109 ? 49.068 99.666 56.214 1.00 54.33 ? 175 GLY B O 1 ATOM 3385 N N . GLU B 1 110 ? 49.667 101.523 55.078 1.00 53.16 ? 176 GLU B N 1 ATOM 3386 C CA . GLU B 1 110 ? 50.347 100.889 53.968 1.00 52.86 ? 176 GLU B CA 1 ATOM 3387 C C . GLU B 1 110 ? 51.820 101.049 54.338 1.00 56.95 ? 176 GLU B C 1 ATOM 3388 O O . GLU B 1 110 ? 52.300 102.178 54.506 1.00 56.21 ? 176 GLU B O 1 ATOM 3389 C CB . GLU B 1 110 ? 50.011 101.594 52.663 1.00 53.68 ? 176 GLU B CB 1 ATOM 3390 C CG . GLU B 1 110 ? 49.082 100.770 51.815 1.00 55.06 ? 176 GLU B CG 1 ATOM 3391 C CD . GLU B 1 110 ? 48.904 101.336 50.427 1.00 53.60 ? 176 GLU B CD 1 ATOM 3392 O OE1 . GLU B 1 110 ? 48.037 102.220 50.258 1.00 38.41 ? 176 GLU B OE1 1 ATOM 3393 O OE2 . GLU B 1 110 ? 49.594 100.863 49.499 1.00 40.11 ? 176 GLU B OE2 1 ATOM 3394 N N . VAL B 1 111 ? 52.486 99.916 54.585 1.00 53.35 ? 177 VAL B N 1 ATOM 3395 C CA . VAL B 1 111 ? 53.859 99.837 55.069 1.00 52.96 ? 177 VAL B CA 1 ATOM 3396 C C . VAL B 1 111 ? 54.858 99.727 53.915 1.00 60.04 ? 177 VAL B C 1 ATOM 3397 O O . VAL B 1 111 ? 54.755 98.819 53.077 1.00 58.87 ? 177 VAL B O 1 ATOM 3398 C CB . VAL B 1 111 ? 53.972 98.696 56.127 1.00 55.30 ? 177 VAL B CB 1 ATOM 3399 C CG1 . VAL B 1 111 ? 55.414 98.250 56.371 1.00 54.41 ? 177 VAL B CG1 1 ATOM 3400 C CG2 . VAL B 1 111 ? 53.306 99.115 57.431 1.00 55.09 ? 177 VAL B CG2 1 ATOM 3401 N N . THR B 1 112 ? 55.842 100.660 53.900 1.00 59.83 ? 178 THR B N 1 ATOM 3402 C CA . THR B 1 112 ? 56.913 100.746 52.880 1.00 60.73 ? 178 THR B CA 1 ATOM 3403 C C . THR B 1 112 ? 58.319 100.373 53.429 1.00 65.59 ? 178 THR B C 1 ATOM 3404 O O . THR B 1 112 ? 59.237 100.166 52.627 1.00 64.67 ? 178 THR B O 1 ATOM 3405 C CB . THR B 1 112 ? 56.909 102.121 52.192 1.00 69.38 ? 178 THR B CB 1 ATOM 3406 O OG1 . THR B 1 112 ? 57.022 103.133 53.195 1.00 73.83 ? 178 THR B OG1 1 ATOM 3407 C CG2 . THR B 1 112 ? 55.653 102.357 51.330 1.00 68.17 ? 178 THR B CG2 1 ATOM 3408 N N . GLU B 1 113 ? 58.472 100.277 54.783 1.00 62.59 ? 179 GLU B N 1 ATOM 3409 C CA . GLU B 1 113 ? 59.724 99.926 55.474 1.00 62.35 ? 179 GLU B CA 1 ATOM 3410 C C . GLU B 1 113 ? 59.495 98.772 56.473 1.00 66.14 ? 179 GLU B C 1 ATOM 3411 O O . GLU B 1 113 ? 58.899 98.959 57.536 1.00 64.43 ? 179 GLU B O 1 ATOM 3412 C CB . GLU B 1 113 ? 60.361 101.162 56.147 1.00 63.50 ? 179 GLU B CB 1 ATOM 3413 N N . MET B 1 114 ? 59.976 97.573 56.098 1.00 64.30 ? 180 MET B N 1 ATOM 3414 C CA . MET B 1 114 ? 59.816 96.323 56.831 1.00 64.05 ? 180 MET B CA 1 ATOM 3415 C C . MET B 1 114 ? 61.163 95.617 57.123 1.00 69.32 ? 180 MET B C 1 ATOM 3416 O O . MET B 1 114 ? 61.666 94.840 56.292 1.00 69.04 ? 180 MET B O 1 ATOM 3417 C CB . MET B 1 114 ? 58.882 95.403 56.043 1.00 66.14 ? 180 MET B CB 1 ATOM 3418 C CG . MET B 1 114 ? 57.860 94.732 56.882 1.00 69.64 ? 180 MET B CG 1 ATOM 3419 S SD . MET B 1 114 ? 56.588 94.063 55.806 1.00 73.68 ? 180 MET B SD 1 ATOM 3420 C CE . MET B 1 114 ? 55.826 92.907 56.919 1.00 70.83 ? 180 MET B CE 1 ATOM 3421 N N . PRO B 1 115 ? 61.738 95.842 58.325 1.00 65.65 ? 181 PRO B N 1 ATOM 3422 C CA . PRO B 1 115 ? 63.017 95.189 58.657 1.00 65.63 ? 181 PRO B CA 1 ATOM 3423 C C . PRO B 1 115 ? 62.983 93.659 58.611 1.00 71.71 ? 181 PRO B C 1 ATOM 3424 O O . PRO B 1 115 ? 62.045 93.046 59.124 1.00 72.60 ? 181 PRO B O 1 ATOM 3425 C CB . PRO B 1 115 ? 63.323 95.711 60.061 1.00 67.42 ? 181 PRO B CB 1 ATOM 3426 C CG . PRO B 1 115 ? 62.555 96.988 60.169 1.00 72.42 ? 181 PRO B CG 1 ATOM 3427 C CD . PRO B 1 115 ? 61.293 96.733 59.414 1.00 67.50 ? 181 PRO B CD 1 ATOM 3428 N N . ALA B 1 116 ? 64.008 93.040 57.981 1.00 67.97 ? 182 ALA B N 1 ATOM 3429 C CA . ALA B 1 116 ? 64.151 91.585 57.854 1.00 67.66 ? 182 ALA B CA 1 ATOM 3430 C C . ALA B 1 116 ? 64.075 90.931 59.228 1.00 73.61 ? 182 ALA B C 1 ATOM 3431 O O . ALA B 1 116 ? 63.570 89.820 59.353 1.00 73.35 ? 182 ALA B O 1 ATOM 3432 C CB . ALA B 1 116 ? 65.465 91.237 57.184 1.00 68.20 ? 182 ALA B CB 1 ATOM 3433 N N . LEU B 1 117 ? 64.558 91.635 60.263 1.00 70.51 ? 183 LEU B N 1 ATOM 3434 C CA . LEU B 1 117 ? 64.464 91.204 61.647 1.00 69.71 ? 183 LEU B CA 1 ATOM 3435 C C . LEU B 1 117 ? 63.458 92.158 62.292 1.00 69.36 ? 183 LEU B C 1 ATOM 3436 O O . LEU B 1 117 ? 63.717 93.359 62.337 1.00 68.33 ? 183 LEU B O 1 ATOM 3437 C CB . LEU B 1 117 ? 65.830 91.280 62.351 1.00 70.40 ? 183 LEU B CB 1 ATOM 3438 C CG . LEU B 1 117 ? 66.470 89.937 62.678 1.00 76.28 ? 183 LEU B CG 1 ATOM 3439 C CD1 . LEU B 1 117 ? 68.004 90.000 62.554 1.00 77.22 ? 183 LEU B CD1 1 ATOM 3440 C CD2 . LEU B 1 117 ? 66.026 89.426 64.052 1.00 77.62 ? 183 LEU B CD2 1 ATOM 3441 N N . PRO B 1 118 ? 62.242 91.699 62.649 1.00 63.30 ? 184 PRO B N 1 ATOM 3442 C CA . PRO B 1 118 ? 61.766 90.308 62.681 1.00 61.83 ? 184 PRO B CA 1 ATOM 3443 C C . PRO B 1 118 ? 60.894 89.817 61.511 1.00 64.57 ? 184 PRO B C 1 ATOM 3444 O O . PRO B 1 118 ? 60.596 88.623 61.442 1.00 63.76 ? 184 PRO B O 1 ATOM 3445 C CB . PRO B 1 118 ? 60.908 90.318 63.943 1.00 63.17 ? 184 PRO B CB 1 ATOM 3446 C CG . PRO B 1 118 ? 60.238 91.675 63.887 1.00 67.54 ? 184 PRO B CG 1 ATOM 3447 C CD . PRO B 1 118 ? 61.258 92.608 63.274 1.00 63.67 ? 184 PRO B CD 1 ATOM 3448 N N . PHE B 1 119 ? 60.464 90.709 60.616 1.00 60.06 ? 185 PHE B N 1 ATOM 3449 C CA . PHE B 1 119 ? 59.470 90.422 59.597 1.00 59.77 ? 185 PHE B CA 1 ATOM 3450 C C . PHE B 1 119 ? 59.822 89.302 58.589 1.00 63.03 ? 185 PHE B C 1 ATOM 3451 O O . PHE B 1 119 ? 58.892 88.772 57.992 1.00 63.80 ? 185 PHE B O 1 ATOM 3452 C CB . PHE B 1 119 ? 59.016 91.707 58.905 1.00 62.06 ? 185 PHE B CB 1 ATOM 3453 C CG . PHE B 1 119 ? 58.347 92.596 59.937 1.00 64.41 ? 185 PHE B CG 1 ATOM 3454 C CD1 . PHE B 1 119 ? 57.100 92.261 60.466 1.00 68.37 ? 185 PHE B CD1 1 ATOM 3455 C CD2 . PHE B 1 119 ? 59.023 93.685 60.486 1.00 67.51 ? 185 PHE B CD2 1 ATOM 3456 C CE1 . PHE B 1 119 ? 56.521 93.033 61.490 1.00 69.60 ? 185 PHE B CE1 1 ATOM 3457 C CE2 . PHE B 1 119 ? 58.442 94.457 61.507 1.00 70.51 ? 185 PHE B CE2 1 ATOM 3458 C CZ . PHE B 1 119 ? 57.195 94.130 61.998 1.00 68.72 ? 185 PHE B CZ 1 ATOM 3459 N N . MET B 1 120 ? 61.074 88.829 58.501 1.00 57.88 ? 186 MET B N 1 ATOM 3460 C CA . MET B 1 120 ? 61.375 87.670 57.648 1.00 56.76 ? 186 MET B CA 1 ATOM 3461 C C . MET B 1 120 ? 60.988 86.369 58.379 1.00 61.65 ? 186 MET B C 1 ATOM 3462 O O . MET B 1 120 ? 60.880 85.319 57.742 1.00 62.05 ? 186 MET B O 1 ATOM 3463 C CB . MET B 1 120 ? 62.847 87.639 57.196 1.00 58.62 ? 186 MET B CB 1 ATOM 3464 C CG . MET B 1 120 ? 63.125 88.425 55.925 1.00 61.66 ? 186 MET B CG 1 ATOM 3465 S SD . MET B 1 120 ? 62.308 87.729 54.452 1.00 65.89 ? 186 MET B SD 1 ATOM 3466 C CE . MET B 1 120 ? 63.351 86.271 54.129 1.00 62.91 ? 186 MET B CE 1 ATOM 3467 N N . LEU B 1 121 ? 60.770 86.445 59.711 1.00 58.14 ? 187 LEU B N 1 ATOM 3468 C CA . LEU B 1 121 ? 60.336 85.310 60.539 1.00 57.72 ? 187 LEU B CA 1 ATOM 3469 C C . LEU B 1 121 ? 58.821 85.236 60.616 1.00 55.59 ? 187 LEU B C 1 ATOM 3470 O O . LEU B 1 121 ? 58.294 84.195 61.016 1.00 55.76 ? 187 LEU B O 1 ATOM 3471 C CB . LEU B 1 121 ? 60.905 85.384 61.975 1.00 58.44 ? 187 LEU B CB 1 ATOM 3472 C CG . LEU B 1 121 ? 62.407 85.414 62.100 1.00 63.90 ? 187 LEU B CG 1 ATOM 3473 C CD1 . LEU B 1 121 ? 62.825 85.340 63.535 1.00 63.94 ? 187 LEU B CD1 1 ATOM 3474 C CD2 . LEU B 1 121 ? 63.017 84.308 61.342 1.00 68.29 ? 187 LEU B CD2 1 ATOM 3475 N N . ALA B 1 122 ? 58.144 86.350 60.267 1.00 46.58 ? 188 ALA B N 1 ATOM 3476 C CA . ALA B 1 122 ? 56.704 86.533 60.261 1.00 45.58 ? 188 ALA B CA 1 ATOM 3477 C C . ALA B 1 122 ? 56.016 85.779 59.111 1.00 49.48 ? 188 ALA B C 1 ATOM 3478 O O . ALA B 1 122 ? 56.303 86.048 57.946 1.00 49.84 ? 188 ALA B O 1 ATOM 3479 C CB . ALA B 1 122 ? 56.376 88.022 60.192 1.00 45.92 ? 188 ALA B CB 1 ATOM 3480 N N . GLU B 1 123 ? 55.109 84.832 59.449 1.00 44.43 ? 189 GLU B N 1 ATOM 3481 C CA . GLU B 1 123 ? 54.319 84.034 58.513 1.00 43.72 ? 189 GLU B CA 1 ATOM 3482 C C . GLU B 1 123 ? 53.118 84.842 58.066 1.00 47.83 ? 189 GLU B C 1 ATOM 3483 O O . GLU B 1 123 ? 52.533 84.578 57.019 1.00 49.55 ? 189 GLU B O 1 ATOM 3484 C CB . GLU B 1 123 ? 53.882 82.721 59.171 1.00 45.18 ? 189 GLU B CB 1 ATOM 3485 C CG . GLU B 1 123 ? 54.956 81.651 59.167 1.00 56.92 ? 189 GLU B CG 1 ATOM 3486 C CD . GLU B 1 123 ? 55.351 81.163 57.793 1.00 78.48 ? 189 GLU B CD 1 ATOM 3487 O OE1 . GLU B 1 123 ? 54.469 81.078 56.907 1.00 90.74 ? 189 GLU B OE1 1 ATOM 3488 O OE2 . GLU B 1 123 ? 56.557 80.891 57.596 1.00 64.83 ? 189 GLU B OE2 1 ATOM 3489 N N . PHE B 1 124 ? 52.756 85.830 58.864 1.00 42.08 ? 190 PHE B N 1 ATOM 3490 C CA . PHE B 1 124 ? 51.664 86.751 58.584 1.00 40.61 ? 190 PHE B CA 1 ATOM 3491 C C . PHE B 1 124 ? 52.216 87.892 57.755 1.00 43.94 ? 190 PHE B C 1 ATOM 3492 O O . PHE B 1 124 ? 53.426 88.121 57.760 1.00 43.59 ? 190 PHE B O 1 ATOM 3493 C CB . PHE B 1 124 ? 51.075 87.289 59.912 1.00 41.74 ? 190 PHE B CB 1 ATOM 3494 C CG . PHE B 1 124 ? 52.076 87.926 60.862 1.00 42.23 ? 190 PHE B CG 1 ATOM 3495 C CD1 . PHE B 1 124 ? 52.751 87.153 61.816 1.00 44.19 ? 190 PHE B CD1 1 ATOM 3496 C CD2 . PHE B 1 124 ? 52.314 89.300 60.829 1.00 42.45 ? 190 PHE B CD2 1 ATOM 3497 C CE1 . PHE B 1 124 ? 53.663 87.740 62.697 1.00 44.69 ? 190 PHE B CE1 1 ATOM 3498 C CE2 . PHE B 1 124 ? 53.212 89.890 61.715 1.00 44.50 ? 190 PHE B CE2 1 ATOM 3499 C CZ . PHE B 1 124 ? 53.881 89.108 62.645 1.00 43.11 ? 190 PHE B CZ 1 ATOM 3500 N N . ASP B 1 125 ? 51.332 88.647 57.092 1.00 40.25 ? 191 ASP B N 1 ATOM 3501 C CA . ASP B 1 125 ? 51.707 89.809 56.285 1.00 39.78 ? 191 ASP B CA 1 ATOM 3502 C C . ASP B 1 125 ? 51.593 91.081 57.085 1.00 42.05 ? 191 ASP B C 1 ATOM 3503 O O . ASP B 1 125 ? 52.474 91.917 57.031 1.00 41.41 ? 191 ASP B O 1 ATOM 3504 C CB . ASP B 1 125 ? 50.846 89.917 55.002 1.00 41.86 ? 191 ASP B CB 1 ATOM 3505 C CG . ASP B 1 125 ? 50.840 88.657 54.160 1.00 49.20 ? 191 ASP B CG 1 ATOM 3506 O OD1 . ASP B 1 125 ? 51.937 88.252 53.681 1.00 51.06 ? 191 ASP B OD1 1 ATOM 3507 O OD2 . ASP B 1 125 ? 49.744 88.062 53.988 1.00 46.29 ? 191 ASP B OD2 1 ATOM 3508 N N . GLY B 1 126 ? 50.523 91.217 57.841 1.00 39.59 ? 192 GLY B N 1 ATOM 3509 C CA . GLY B 1 126 ? 50.275 92.430 58.606 1.00 38.78 ? 192 GLY B CA 1 ATOM 3510 C C . GLY B 1 126 ? 49.616 92.236 59.946 1.00 40.80 ? 192 GLY B C 1 ATOM 3511 O O . GLY B 1 126 ? 49.640 91.139 60.511 1.00 40.50 ? 192 GLY B O 1 ATOM 3512 N N . VAL B 1 127 ? 49.071 93.333 60.486 1.00 35.56 ? 193 VAL B N 1 ATOM 3513 C CA . VAL B 1 127 ? 48.503 93.339 61.822 1.00 34.94 ? 193 VAL B CA 1 ATOM 3514 C C . VAL B 1 127 ? 47.136 94.034 61.878 1.00 40.14 ? 193 VAL B C 1 ATOM 3515 O O . VAL B 1 127 ? 46.936 95.071 61.265 1.00 40.66 ? 193 VAL B O 1 ATOM 3516 C CB . VAL B 1 127 ? 49.517 93.935 62.867 1.00 37.77 ? 193 VAL B CB 1 ATOM 3517 C CG1 . VAL B 1 127 ? 48.894 94.085 64.261 1.00 37.35 ? 193 VAL B CG1 1 ATOM 3518 C CG2 . VAL B 1 127 ? 50.797 93.100 62.961 1.00 36.99 ? 193 VAL B CG2 1 ATOM 3519 N N . VAL B 1 128 ? 46.211 93.448 62.636 1.00 36.32 ? 194 VAL B N 1 ATOM 3520 C CA . VAL B 1 128 ? 44.915 94.020 62.959 1.00 36.64 ? 194 VAL B CA 1 ATOM 3521 C C . VAL B 1 128 ? 44.947 94.329 64.480 1.00 40.51 ? 194 VAL B C 1 ATOM 3522 O O . VAL B 1 128 ? 44.853 93.416 65.310 1.00 40.07 ? 194 VAL B O 1 ATOM 3523 C CB . VAL B 1 128 ? 43.712 93.139 62.542 1.00 41.00 ? 194 VAL B CB 1 ATOM 3524 C CG1 . VAL B 1 128 ? 42.405 93.702 63.103 1.00 40.89 ? 194 VAL B CG1 1 ATOM 3525 C CG2 . VAL B 1 128 ? 43.623 93.026 61.018 1.00 41.15 ? 194 VAL B CG2 1 ATOM 3526 N N . GLY B 1 129 ? 45.156 95.602 64.809 1.00 35.29 ? 195 GLY B N 1 ATOM 3527 C CA . GLY B 1 129 ? 45.184 96.072 66.182 1.00 34.18 ? 195 GLY B CA 1 ATOM 3528 C C . GLY B 1 129 ? 43.800 95.994 66.806 1.00 38.29 ? 195 GLY B C 1 ATOM 3529 O O . GLY B 1 129 ? 42.833 96.578 66.284 1.00 37.72 ? 195 GLY B O 1 ATOM 3530 N N . MET B 1 130 ? 43.700 95.227 67.919 1.00 34.32 ? 196 MET B N 1 ATOM 3531 C CA . MET B 1 130 ? 42.495 94.981 68.699 1.00 33.67 ? 196 MET B CA 1 ATOM 3532 C C . MET B 1 130 ? 42.514 95.817 69.992 1.00 37.22 ? 196 MET B C 1 ATOM 3533 O O . MET B 1 130 ? 41.611 95.692 70.827 1.00 37.45 ? 196 MET B O 1 ATOM 3534 C CB . MET B 1 130 ? 42.324 93.467 69.004 1.00 35.75 ? 196 MET B CB 1 ATOM 3535 C CG . MET B 1 130 ? 42.076 92.576 67.778 1.00 39.45 ? 196 MET B CG 1 ATOM 3536 S SD . MET B 1 130 ? 40.756 93.124 66.645 1.00 45.12 ? 196 MET B SD 1 ATOM 3537 C CE . MET B 1 130 ? 39.292 92.718 67.603 1.00 41.98 ? 196 MET B CE 1 ATOM 3538 N N . GLY B 1 131 ? 43.523 96.676 70.122 1.00 33.76 ? 197 GLY B N 1 ATOM 3539 C CA . GLY B 1 131 ? 43.690 97.597 71.242 1.00 33.04 ? 197 GLY B CA 1 ATOM 3540 C C . GLY B 1 131 ? 42.767 98.794 71.152 1.00 38.38 ? 197 GLY B C 1 ATOM 3541 O O . GLY B 1 131 ? 42.047 98.974 70.158 1.00 36.18 ? 197 GLY B O 1 ATOM 3542 N N . PHE B 1 132 ? 42.781 99.628 72.201 1.00 38.59 ? 198 PHE B N 1 ATOM 3543 C CA . PHE B 1 132 ? 41.929 100.816 72.289 1.00 39.39 ? 198 PHE B CA 1 ATOM 3544 C C . PHE B 1 132 ? 42.472 102.002 71.468 1.00 47.39 ? 198 PHE B C 1 ATOM 3545 O O . PHE B 1 132 ? 43.677 102.057 71.190 1.00 46.00 ? 198 PHE B O 1 ATOM 3546 C CB . PHE B 1 132 ? 41.813 101.219 73.754 1.00 41.31 ? 198 PHE B CB 1 ATOM 3547 C CG . PHE B 1 132 ? 41.078 100.264 74.664 1.00 42.86 ? 198 PHE B CG 1 ATOM 3548 C CD1 . PHE B 1 132 ? 41.724 99.165 75.213 1.00 45.06 ? 198 PHE B CD1 1 ATOM 3549 C CD2 . PHE B 1 132 ? 39.760 100.506 75.031 1.00 45.46 ? 198 PHE B CD2 1 ATOM 3550 C CE1 . PHE B 1 132 ? 41.058 98.320 76.092 1.00 46.39 ? 198 PHE B CE1 1 ATOM 3551 C CE2 . PHE B 1 132 ? 39.092 99.650 75.898 1.00 48.12 ? 198 PHE B CE2 1 ATOM 3552 C CZ . PHE B 1 132 ? 39.738 98.555 76.407 1.00 45.75 ? 198 PHE B CZ 1 ATOM 3553 N N . ILE B 1 133 ? 41.579 102.981 71.131 1.00 46.87 ? 199 ILE B N 1 ATOM 3554 C CA . ILE B 1 133 ? 41.922 104.215 70.400 1.00 47.51 ? 199 ILE B CA 1 ATOM 3555 C C . ILE B 1 133 ? 43.011 105.055 71.121 1.00 53.03 ? 199 ILE B C 1 ATOM 3556 O O . ILE B 1 133 ? 43.819 105.697 70.455 1.00 53.58 ? 199 ILE B O 1 ATOM 3557 C CB . ILE B 1 133 ? 40.655 105.034 70.062 1.00 50.81 ? 199 ILE B CB 1 ATOM 3558 C CG1 . ILE B 1 133 ? 40.944 106.094 68.955 1.00 51.12 ? 199 ILE B CG1 1 ATOM 3559 C CG2 . ILE B 1 133 ? 39.997 105.637 71.320 1.00 52.20 ? 199 ILE B CG2 1 ATOM 3560 C CD1 . ILE B 1 133 ? 39.694 106.643 68.220 1.00 52.68 ? 199 ILE B CD1 1 ATOM 3561 N N . GLU B 1 134 ? 43.070 104.985 72.463 1.00 49.55 ? 200 GLU B N 1 ATOM 3562 C CA . GLU B 1 134 ? 44.052 105.688 73.288 1.00 49.53 ? 200 GLU B CA 1 ATOM 3563 C C . GLU B 1 134 ? 45.500 105.344 72.904 1.00 54.91 ? 200 GLU B C 1 ATOM 3564 O O . GLU B 1 134 ? 46.387 106.177 73.102 1.00 56.58 ? 200 GLU B O 1 ATOM 3565 C CB . GLU B 1 134 ? 43.816 105.390 74.789 1.00 50.94 ? 200 GLU B CB 1 ATOM 3566 C CG . GLU B 1 134 ? 42.527 105.964 75.379 1.00 56.17 ? 200 GLU B CG 1 ATOM 3567 C CD . GLU B 1 134 ? 41.242 105.163 75.256 1.00 65.07 ? 200 GLU B CD 1 ATOM 3568 O OE1 . GLU B 1 134 ? 41.117 104.353 74.312 1.00 46.38 ? 200 GLU B OE1 1 ATOM 3569 O OE2 . GLU B 1 134 ? 40.323 105.403 76.072 1.00 61.87 ? 200 GLU B OE2 1 ATOM 3570 N N . GLN B 1 135 ? 45.744 104.134 72.369 1.00 50.49 ? 201 GLN B N 1 ATOM 3571 C CA . GLN B 1 135 ? 47.088 103.677 71.988 1.00 50.28 ? 201 GLN B CA 1 ATOM 3572 C C . GLN B 1 135 ? 47.289 103.634 70.465 1.00 52.53 ? 201 GLN B C 1 ATOM 3573 O O . GLN B 1 135 ? 48.326 103.149 70.001 1.00 50.66 ? 201 GLN B O 1 ATOM 3574 C CB . GLN B 1 135 ? 47.420 102.310 72.621 1.00 51.95 ? 201 GLN B CB 1 ATOM 3575 C CG . GLN B 1 135 ? 47.153 102.205 74.114 1.00 67.42 ? 201 GLN B CG 1 ATOM 3576 C CD . GLN B 1 135 ? 48.380 102.419 74.954 1.00 90.84 ? 201 GLN B CD 1 ATOM 3577 O OE1 . GLN B 1 135 ? 48.693 103.546 75.345 1.00 88.93 ? 201 GLN B OE1 1 ATOM 3578 N NE2 . GLN B 1 135 ? 49.080 101.337 75.308 1.00 85.82 ? 201 GLN B NE2 1 ATOM 3579 N N . ALA B 1 136 ? 46.309 104.159 69.697 1.00 49.40 ? 202 ALA B N 1 ATOM 3580 C CA . ALA B 1 136 ? 46.360 104.192 68.240 1.00 50.11 ? 202 ALA B CA 1 ATOM 3581 C C . ALA B 1 136 ? 47.278 105.327 67.772 1.00 58.10 ? 202 ALA B C 1 ATOM 3582 O O . ALA B 1 136 ? 47.119 106.469 68.203 1.00 58.40 ? 202 ALA B O 1 ATOM 3583 C CB . ALA B 1 136 ? 44.954 104.348 67.664 1.00 50.46 ? 202 ALA B CB 1 ATOM 3584 N N . ILE B 1 137 ? 48.283 104.993 66.945 1.00 57.05 ? 203 ILE B N 1 ATOM 3585 C CA . ILE B 1 137 ? 49.244 105.955 66.384 1.00 57.26 ? 203 ILE B CA 1 ATOM 3586 C C . ILE B 1 137 ? 48.526 106.759 65.295 1.00 63.41 ? 203 ILE B C 1 ATOM 3587 O O . ILE B 1 137 ? 47.772 106.194 64.498 1.00 64.46 ? 203 ILE B O 1 ATOM 3588 C CB . ILE B 1 137 ? 50.565 105.267 65.888 1.00 59.68 ? 203 ILE B CB 1 ATOM 3589 C CG1 . ILE B 1 137 ? 51.235 104.393 66.991 1.00 58.89 ? 203 ILE B CG1 1 ATOM 3590 C CG2 . ILE B 1 137 ? 51.572 106.270 65.287 1.00 60.32 ? 203 ILE B CG2 1 ATOM 3591 C CD1 . ILE B 1 137 ? 51.595 105.070 68.352 1.00 55.65 ? 203 ILE B CD1 1 ATOM 3592 N N . GLY B 1 138 ? 48.705 108.075 65.332 1.00 60.44 ? 204 GLY B N 1 ATOM 3593 C CA . GLY B 1 138 ? 48.062 109.004 64.408 1.00 60.38 ? 204 GLY B CA 1 ATOM 3594 C C . GLY B 1 138 ? 46.592 109.218 64.707 1.00 64.46 ? 204 GLY B C 1 ATOM 3595 O O . GLY B 1 138 ? 45.877 109.784 63.875 1.00 64.81 ? 204 GLY B O 1 ATOM 3596 N N . ARG B 1 139 ? 46.135 108.756 65.903 1.00 60.57 ? 205 ARG B N 1 ATOM 3597 C CA . ARG B 1 139 ? 44.754 108.819 66.407 1.00 60.19 ? 205 ARG B CA 1 ATOM 3598 C C . ARG B 1 139 ? 43.736 108.240 65.397 1.00 62.79 ? 205 ARG B C 1 ATOM 3599 O O . ARG B 1 139 ? 42.623 108.759 65.239 1.00 62.72 ? 205 ARG B O 1 ATOM 3600 C CB . ARG B 1 139 ? 44.384 110.244 66.875 1.00 60.93 ? 205 ARG B CB 1 ATOM 3601 N N . VAL B 1 140 ? 44.138 107.152 64.713 1.00 57.30 ? 206 VAL B N 1 ATOM 3602 C CA . VAL B 1 140 ? 43.309 106.460 63.725 1.00 55.97 ? 206 VAL B CA 1 ATOM 3603 C C . VAL B 1 140 ? 42.278 105.592 64.481 1.00 58.25 ? 206 VAL B C 1 ATOM 3604 O O . VAL B 1 140 ? 42.646 104.879 65.423 1.00 57.25 ? 206 VAL B O 1 ATOM 3605 C CB . VAL B 1 140 ? 44.184 105.636 62.738 1.00 59.39 ? 206 VAL B CB 1 ATOM 3606 C CG1 . VAL B 1 140 ? 43.330 104.865 61.741 1.00 58.47 ? 206 VAL B CG1 1 ATOM 3607 C CG2 . VAL B 1 140 ? 45.182 106.530 62.004 1.00 59.35 ? 206 VAL B CG2 1 ATOM 3608 N N . THR B 1 141 ? 40.989 105.680 64.095 1.00 53.25 ? 207 THR B N 1 ATOM 3609 C CA . THR B 1 141 ? 39.954 104.882 64.743 1.00 52.38 ? 207 THR B CA 1 ATOM 3610 C C . THR B 1 141 ? 40.213 103.367 64.515 1.00 54.73 ? 207 THR B C 1 ATOM 3611 O O . THR B 1 141 ? 40.262 102.934 63.352 1.00 54.29 ? 207 THR B O 1 ATOM 3612 C CB . THR B 1 141 ? 38.557 105.315 64.298 1.00 56.08 ? 207 THR B CB 1 ATOM 3613 O OG1 . THR B 1 141 ? 38.415 106.716 64.505 1.00 53.41 ? 207 THR B OG1 1 ATOM 3614 C CG2 . THR B 1 141 ? 37.454 104.586 65.062 1.00 55.61 ? 207 THR B CG2 1 ATOM 3615 N N . PRO B 1 142 ? 40.415 102.567 65.606 1.00 49.12 ? 208 PRO B N 1 ATOM 3616 C CA . PRO B 1 142 ? 40.641 101.121 65.437 1.00 47.96 ? 208 PRO B CA 1 ATOM 3617 C C . PRO B 1 142 ? 39.434 100.423 64.791 1.00 48.72 ? 208 PRO B C 1 ATOM 3618 O O . PRO B 1 142 ? 38.286 100.880 64.923 1.00 47.84 ? 208 PRO B O 1 ATOM 3619 C CB . PRO B 1 142 ? 40.892 100.632 66.874 1.00 49.57 ? 208 PRO B CB 1 ATOM 3620 C CG . PRO B 1 142 ? 41.308 101.842 67.627 1.00 54.36 ? 208 PRO B CG 1 ATOM 3621 C CD . PRO B 1 142 ? 40.439 102.920 67.039 1.00 50.58 ? 208 PRO B CD 1 ATOM 3622 N N . ILE B 1 143 ? 39.710 99.337 64.061 1.00 42.23 ? 209 ILE B N 1 ATOM 3623 C CA . ILE B 1 143 ? 38.716 98.549 63.339 1.00 41.72 ? 209 ILE B CA 1 ATOM 3624 C C . ILE B 1 143 ? 37.528 98.097 64.213 1.00 47.79 ? 209 ILE B C 1 ATOM 3625 O O . ILE B 1 143 ? 36.402 98.107 63.712 1.00 48.49 ? 209 ILE B O 1 ATOM 3626 C CB . ILE B 1 143 ? 39.373 97.350 62.579 1.00 44.38 ? 209 ILE B CB 1 ATOM 3627 C CG1 . ILE B 1 143 ? 38.470 96.875 61.406 1.00 44.15 ? 209 ILE B CG1 1 ATOM 3628 C CG2 . ILE B 1 143 ? 39.790 96.201 63.529 1.00 44.44 ? 209 ILE B CG2 1 ATOM 3629 C CD1 . ILE B 1 143 ? 39.132 95.939 60.382 1.00 41.98 ? 209 ILE B CD1 1 ATOM 3630 N N . PHE B 1 144 ? 37.766 97.686 65.487 1.00 43.62 ? 210 PHE B N 1 ATOM 3631 C CA . PHE B 1 144 ? 36.671 97.216 66.338 1.00 42.87 ? 210 PHE B CA 1 ATOM 3632 C C . PHE B 1 144 ? 35.684 98.337 66.675 1.00 47.67 ? 210 PHE B C 1 ATOM 3633 O O . PHE B 1 144 ? 34.476 98.102 66.635 1.00 47.92 ? 210 PHE B O 1 ATOM 3634 C CB . PHE B 1 144 ? 37.165 96.471 67.603 1.00 43.93 ? 210 PHE B CB 1 ATOM 3635 C CG . PHE B 1 144 ? 36.088 95.607 68.224 1.00 43.31 ? 210 PHE B CG 1 ATOM 3636 C CD1 . PHE B 1 144 ? 35.630 94.464 67.572 1.00 44.28 ? 210 PHE B CD1 1 ATOM 3637 C CD2 . PHE B 1 144 ? 35.532 95.937 69.458 1.00 43.05 ? 210 PHE B CD2 1 ATOM 3638 C CE1 . PHE B 1 144 ? 34.624 93.678 68.131 1.00 44.39 ? 210 PHE B CE1 1 ATOM 3639 C CE2 . PHE B 1 144 ? 34.529 95.140 70.027 1.00 44.57 ? 210 PHE B CE2 1 ATOM 3640 C CZ . PHE B 1 144 ? 34.087 94.014 69.364 1.00 42.53 ? 210 PHE B CZ 1 ATOM 3641 N N . ASP B 1 145 ? 36.196 99.561 66.943 1.00 44.57 ? 211 ASP B N 1 ATOM 3642 C CA . ASP B 1 145 ? 35.380 100.746 67.202 1.00 44.13 ? 211 ASP B CA 1 ATOM 3643 C C . ASP B 1 145 ? 34.448 101.004 66.005 1.00 47.56 ? 211 ASP B C 1 ATOM 3644 O O . ASP B 1 145 ? 33.252 101.234 66.195 1.00 47.02 ? 211 ASP B O 1 ATOM 3645 C CB . ASP B 1 145 ? 36.279 101.958 67.451 1.00 45.48 ? 211 ASP B CB 1 ATOM 3646 C CG . ASP B 1 145 ? 37.116 101.873 68.715 1.00 55.83 ? 211 ASP B CG 1 ATOM 3647 O OD1 . ASP B 1 145 ? 37.886 100.901 68.856 1.00 53.20 ? 211 ASP B OD1 1 ATOM 3648 O OD2 . ASP B 1 145 ? 37.067 102.827 69.520 1.00 67.51 ? 211 ASP B OD2 1 ATOM 3649 N N . ASN B 1 146 ? 34.987 100.891 64.778 1.00 42.73 ? 212 ASN B N 1 ATOM 3650 C CA . ASN B 1 146 ? 34.227 101.101 63.554 1.00 42.29 ? 212 ASN B CA 1 ATOM 3651 C C . ASN B 1 146 ? 33.170 100.038 63.347 1.00 47.96 ? 212 ASN B C 1 ATOM 3652 O O . ASN B 1 146 ? 32.076 100.359 62.870 1.00 47.38 ? 212 ASN B O 1 ATOM 3653 C CB . ASN B 1 146 ? 35.157 101.219 62.346 1.00 45.10 ? 212 ASN B CB 1 ATOM 3654 C CG . ASN B 1 146 ? 35.899 102.531 62.276 1.00 53.01 ? 212 ASN B CG 1 ATOM 3655 O OD1 . ASN B 1 146 ? 35.385 103.578 62.652 1.00 47.74 ? 212 ASN B OD1 1 ATOM 3656 N ND2 . ASN B 1 146 ? 37.114 102.517 61.760 1.00 39.75 ? 212 ASN B ND2 1 ATOM 3657 N N . ILE B 1 147 ? 33.472 98.777 63.735 1.00 46.46 ? 213 ILE B N 1 ATOM 3658 C CA . ILE B 1 147 ? 32.518 97.666 63.643 1.00 46.27 ? 213 ILE B CA 1 ATOM 3659 C C . ILE B 1 147 ? 31.376 97.910 64.653 1.00 50.29 ? 213 ILE B C 1 ATOM 3660 O O . ILE B 1 147 ? 30.205 97.758 64.297 1.00 49.30 ? 213 ILE B O 1 ATOM 3661 C CB . ILE B 1 147 ? 33.204 96.277 63.768 1.00 49.07 ? 213 ILE B CB 1 ATOM 3662 C CG1 . ILE B 1 147 ? 34.095 96.006 62.529 1.00 49.11 ? 213 ILE B CG1 1 ATOM 3663 C CG2 . ILE B 1 147 ? 32.157 95.162 63.916 1.00 48.98 ? 213 ILE B CG2 1 ATOM 3664 C CD1 . ILE B 1 147 ? 35.099 94.813 62.661 1.00 52.98 ? 213 ILE B CD1 1 ATOM 3665 N N . ILE B 1 148 ? 31.722 98.362 65.880 1.00 47.87 ? 214 ILE B N 1 ATOM 3666 C CA . ILE B 1 148 ? 30.753 98.721 66.921 1.00 47.79 ? 214 ILE B CA 1 ATOM 3667 C C . ILE B 1 148 ? 29.770 99.782 66.403 1.00 53.46 ? 214 ILE B C 1 ATOM 3668 O O . ILE B 1 148 ? 28.554 99.619 66.580 1.00 54.23 ? 214 ILE B O 1 ATOM 3669 C CB . ILE B 1 148 ? 31.460 99.128 68.246 1.00 50.57 ? 214 ILE B CB 1 ATOM 3670 C CG1 . ILE B 1 148 ? 32.066 97.922 68.973 1.00 50.56 ? 214 ILE B CG1 1 ATOM 3671 C CG2 . ILE B 1 148 ? 30.561 99.925 69.178 1.00 50.56 ? 214 ILE B CG2 1 ATOM 3672 C CD1 . ILE B 1 148 ? 31.321 96.575 68.894 1.00 56.53 ? 214 ILE B CD1 1 ATOM 3673 N N . SER B 1 149 ? 30.289 100.832 65.712 1.00 50.18 ? 215 SER B N 1 ATOM 3674 C CA . SER B 1 149 ? 29.487 101.914 65.119 1.00 49.46 ? 215 SER B CA 1 ATOM 3675 C C . SER B 1 149 ? 28.384 101.388 64.190 1.00 53.44 ? 215 SER B C 1 ATOM 3676 O O . SER B 1 149 ? 27.330 102.011 64.120 1.00 55.65 ? 215 SER B O 1 ATOM 3677 C CB . SER B 1 149 ? 30.376 102.900 64.366 1.00 51.66 ? 215 SER B CB 1 ATOM 3678 O OG . SER B 1 149 ? 31.216 103.601 65.264 1.00 59.05 ? 215 SER B OG 1 ATOM 3679 N N . GLN B 1 150 ? 28.593 100.227 63.532 1.00 47.37 ? 216 GLN B N 1 ATOM 3680 C CA . GLN B 1 150 ? 27.590 99.628 62.639 1.00 46.25 ? 216 GLN B CA 1 ATOM 3681 C C . GLN B 1 150 ? 26.393 99.095 63.400 1.00 49.63 ? 216 GLN B C 1 ATOM 3682 O O . GLN B 1 150 ? 25.337 98.878 62.794 1.00 51.07 ? 216 GLN B O 1 ATOM 3683 C CB . GLN B 1 150 ? 28.177 98.508 61.763 1.00 47.36 ? 216 GLN B CB 1 ATOM 3684 C CG . GLN B 1 150 ? 29.443 98.898 61.012 1.00 58.82 ? 216 GLN B CG 1 ATOM 3685 C CD . GLN B 1 150 ? 29.909 97.845 60.036 1.00 60.33 ? 216 GLN B CD 1 ATOM 3686 O OE1 . GLN B 1 150 ? 29.600 96.659 60.150 1.00 52.84 ? 216 GLN B OE1 1 ATOM 3687 N NE2 . GLN B 1 150 ? 30.697 98.264 59.068 1.00 48.25 ? 216 GLN B NE2 1 ATOM 3688 N N . GLY B 1 151 ? 26.567 98.866 64.703 1.00 44.08 ? 217 GLY B N 1 ATOM 3689 C CA . GLY B 1 151 ? 25.527 98.332 65.577 1.00 43.29 ? 217 GLY B CA 1 ATOM 3690 C C . GLY B 1 151 ? 24.935 97.022 65.100 1.00 47.28 ? 217 GLY B C 1 ATOM 3691 O O . GLY B 1 151 ? 23.711 96.846 65.146 1.00 47.15 ? 217 GLY B O 1 ATOM 3692 N N . VAL B 1 152 ? 25.800 96.102 64.608 1.00 43.19 ? 218 VAL B N 1 ATOM 3693 C CA . VAL B 1 152 ? 25.379 94.783 64.097 1.00 42.91 ? 218 VAL B CA 1 ATOM 3694 C C . VAL B 1 152 ? 25.741 93.618 65.064 1.00 44.79 ? 218 VAL B C 1 ATOM 3695 O O . VAL B 1 152 ? 25.059 92.594 65.071 1.00 45.36 ? 218 VAL B O 1 ATOM 3696 C CB . VAL B 1 152 ? 25.862 94.505 62.645 1.00 46.64 ? 218 VAL B CB 1 ATOM 3697 C CG1 . VAL B 1 152 ? 25.294 95.545 61.678 1.00 46.40 ? 218 VAL B CG1 1 ATOM 3698 C CG2 . VAL B 1 152 ? 27.389 94.427 62.543 1.00 45.88 ? 218 VAL B CG2 1 ATOM 3699 N N . LEU B 1 153 ? 26.764 93.809 65.903 1.00 39.89 ? 219 LEU B N 1 ATOM 3700 C CA . LEU B 1 153 ? 27.272 92.831 66.869 1.00 39.28 ? 219 LEU B CA 1 ATOM 3701 C C . LEU B 1 153 ? 26.372 92.671 68.099 1.00 42.46 ? 219 LEU B C 1 ATOM 3702 O O . LEU B 1 153 ? 25.889 93.680 68.651 1.00 42.22 ? 219 LEU B O 1 ATOM 3703 C CB . LEU B 1 153 ? 28.713 93.187 67.295 1.00 38.98 ? 219 LEU B CB 1 ATOM 3704 C CG . LEU B 1 153 ? 29.804 93.179 66.215 1.00 41.88 ? 219 LEU B CG 1 ATOM 3705 C CD1 . LEU B 1 153 ? 31.136 93.422 66.835 1.00 40.99 ? 219 LEU B CD1 1 ATOM 3706 C CD2 . LEU B 1 153 ? 29.835 91.852 65.447 1.00 44.16 ? 219 LEU B CD2 1 ATOM 3707 N N . LYS B 1 154 ? 26.154 91.402 68.525 1.00 37.22 ? 220 LYS B N 1 ATOM 3708 C CA . LYS B 1 154 ? 25.305 91.066 69.671 1.00 36.39 ? 220 LYS B CA 1 ATOM 3709 C C . LYS B 1 154 ? 25.841 91.704 70.952 1.00 39.39 ? 220 LYS B C 1 ATOM 3710 O O . LYS B 1 154 ? 25.058 92.238 71.734 1.00 39.86 ? 220 LYS B O 1 ATOM 3711 C CB . LYS B 1 154 ? 25.106 89.545 69.827 1.00 38.61 ? 220 LYS B CB 1 ATOM 3712 N N . GLU B 1 155 ? 27.176 91.697 71.140 1.00 33.76 ? 221 GLU B N 1 ATOM 3713 C CA . GLU B 1 155 ? 27.827 92.287 72.316 1.00 31.37 ? 221 GLU B CA 1 ATOM 3714 C C . GLU B 1 155 ? 29.090 93.060 71.934 1.00 34.85 ? 221 GLU B C 1 ATOM 3715 O O . GLU B 1 155 ? 29.748 92.750 70.929 1.00 33.19 ? 221 GLU B O 1 ATOM 3716 C CB . GLU B 1 155 ? 28.160 91.218 73.386 1.00 31.69 ? 221 GLU B CB 1 ATOM 3717 C CG . GLU B 1 155 ? 26.992 90.549 74.118 1.00 42.63 ? 221 GLU B CG 1 ATOM 3718 C CD . GLU B 1 155 ? 25.852 91.339 74.769 1.00 68.12 ? 221 GLU B CD 1 ATOM 3719 O OE1 . GLU B 1 155 ? 26.065 92.506 75.174 1.00 50.08 ? 221 GLU B OE1 1 ATOM 3720 O OE2 . GLU B 1 155 ? 24.718 90.804 74.805 1.00 66.86 ? 221 GLU B OE2 1 ATOM 3721 N N . ASP B 1 156 ? 29.451 94.028 72.784 1.00 32.57 ? 222 ASP B N 1 ATOM 3722 C CA . ASP B 1 156 ? 30.635 94.861 72.605 1.00 33.26 ? 222 ASP B CA 1 ATOM 3723 C C . ASP B 1 156 ? 31.866 94.118 73.113 1.00 32.42 ? 222 ASP B C 1 ATOM 3724 O O . ASP B 1 156 ? 32.610 94.637 73.950 1.00 32.13 ? 222 ASP B O 1 ATOM 3725 C CB . ASP B 1 156 ? 30.428 96.171 73.372 1.00 36.73 ? 222 ASP B CB 1 ATOM 3726 C CG . ASP B 1 156 ? 31.167 97.368 72.829 1.00 53.69 ? 222 ASP B CG 1 ATOM 3727 O OD1 . ASP B 1 156 ? 32.224 97.171 72.166 1.00 53.88 ? 222 ASP B OD1 1 ATOM 3728 O OD2 . ASP B 1 156 ? 30.825 98.504 73.237 1.00 62.98 ? 222 ASP B OD2 1 ATOM 3729 N N . VAL B 1 157 ? 32.059 92.890 72.622 1.00 26.32 ? 223 VAL B N 1 ATOM 3730 C CA . VAL B 1 157 ? 33.165 92.015 73.044 1.00 24.69 ? 223 VAL B CA 1 ATOM 3731 C C . VAL B 1 157 ? 33.755 91.236 71.828 1.00 30.51 ? 223 VAL B C 1 ATOM 3732 O O . VAL B 1 157 ? 33.124 91.151 70.769 1.00 30.25 ? 223 VAL B O 1 ATOM 3733 C CB . VAL B 1 157 ? 32.696 91.040 74.192 1.00 26.80 ? 223 VAL B CB 1 ATOM 3734 C CG1 . VAL B 1 157 ? 31.723 91.700 75.175 1.00 25.75 ? 223 VAL B CG1 1 ATOM 3735 C CG2 . VAL B 1 157 ? 32.066 89.782 73.636 1.00 26.28 ? 223 VAL B CG2 1 ATOM 3736 N N . PHE B 1 158 ? 34.942 90.640 72.008 1.00 26.61 ? 224 PHE B N 1 ATOM 3737 C CA . PHE B 1 158 ? 35.591 89.781 71.023 1.00 27.22 ? 224 PHE B CA 1 ATOM 3738 C C . PHE B 1 158 ? 36.365 88.753 71.796 1.00 33.25 ? 224 PHE B C 1 ATOM 3739 O O . PHE B 1 158 ? 36.850 89.055 72.896 1.00 32.19 ? 224 PHE B O 1 ATOM 3740 C CB . PHE B 1 158 ? 36.474 90.535 69.973 1.00 28.44 ? 224 PHE B CB 1 ATOM 3741 C CG . PHE B 1 158 ? 37.554 91.437 70.534 1.00 28.67 ? 224 PHE B CG 1 ATOM 3742 C CD1 . PHE B 1 158 ? 38.822 90.938 70.823 1.00 28.63 ? 224 PHE B CD1 1 ATOM 3743 C CD2 . PHE B 1 158 ? 37.310 92.797 70.751 1.00 28.74 ? 224 PHE B CD2 1 ATOM 3744 C CE1 . PHE B 1 158 ? 39.817 91.772 71.332 1.00 28.67 ? 224 PHE B CE1 1 ATOM 3745 C CE2 . PHE B 1 158 ? 38.306 93.630 71.257 1.00 30.77 ? 224 PHE B CE2 1 ATOM 3746 C CZ . PHE B 1 158 ? 39.558 93.114 71.540 1.00 28.96 ? 224 PHE B CZ 1 ATOM 3747 N N . SER B 1 159 ? 36.416 87.509 71.253 1.00 30.57 ? 225 SER B N 1 ATOM 3748 C CA . SER B 1 159 ? 37.044 86.371 71.937 1.00 30.38 ? 225 SER B CA 1 ATOM 3749 C C . SER B 1 159 ? 38.080 85.628 71.126 1.00 31.74 ? 225 SER B C 1 ATOM 3750 O O . SER B 1 159 ? 37.957 85.531 69.911 1.00 30.83 ? 225 SER B O 1 ATOM 3751 C CB . SER B 1 159 ? 35.986 85.397 72.441 1.00 32.42 ? 225 SER B CB 1 ATOM 3752 O OG . SER B 1 159 ? 34.987 86.066 73.182 1.00 38.00 ? 225 SER B OG 1 ATOM 3753 N N . PHE B 1 160 ? 39.073 85.053 71.826 1.00 28.40 ? 226 PHE B N 1 ATOM 3754 C CA . PHE B 1 160 ? 40.183 84.312 71.238 1.00 28.31 ? 226 PHE B CA 1 ATOM 3755 C C . PHE B 1 160 ? 40.279 82.929 71.766 1.00 33.10 ? 226 PHE B C 1 ATOM 3756 O O . PHE B 1 160 ? 40.218 82.709 72.980 1.00 35.25 ? 226 PHE B O 1 ATOM 3757 C CB . PHE B 1 160 ? 41.523 85.000 71.534 1.00 29.95 ? 226 PHE B CB 1 ATOM 3758 C CG . PHE B 1 160 ? 41.843 86.167 70.654 1.00 31.37 ? 226 PHE B CG 1 ATOM 3759 C CD1 . PHE B 1 160 ? 41.201 87.389 70.833 1.00 33.91 ? 226 PHE B CD1 1 ATOM 3760 C CD2 . PHE B 1 160 ? 42.809 86.060 69.658 1.00 32.86 ? 226 PHE B CD2 1 ATOM 3761 C CE1 . PHE B 1 160 ? 41.498 88.476 70.010 1.00 35.00 ? 226 PHE B CE1 1 ATOM 3762 C CE2 . PHE B 1 160 ? 43.112 87.147 68.845 1.00 35.24 ? 226 PHE B CE2 1 ATOM 3763 C CZ . PHE B 1 160 ? 42.478 88.356 69.046 1.00 33.44 ? 226 PHE B CZ 1 ATOM 3764 N N . TYR B 1 161 ? 40.489 82.004 70.849 1.00 27.99 ? 227 TYR B N 1 ATOM 3765 C CA . TYR B 1 161 ? 40.765 80.614 71.116 1.00 27.27 ? 227 TYR B CA 1 ATOM 3766 C C . TYR B 1 161 ? 42.064 80.327 70.372 1.00 30.53 ? 227 TYR B C 1 ATOM 3767 O O . TYR B 1 161 ? 42.153 80.613 69.184 1.00 30.18 ? 227 TYR B O 1 ATOM 3768 C CB . TYR B 1 161 ? 39.633 79.708 70.598 1.00 28.14 ? 227 TYR B CB 1 ATOM 3769 C CG . TYR B 1 161 ? 40.060 78.259 70.528 1.00 30.65 ? 227 TYR B CG 1 ATOM 3770 C CD1 . TYR B 1 161 ? 40.405 77.553 71.686 1.00 32.57 ? 227 TYR B CD1 1 ATOM 3771 C CD2 . TYR B 1 161 ? 40.145 77.594 69.307 1.00 30.35 ? 227 TYR B CD2 1 ATOM 3772 C CE1 . TYR B 1 161 ? 40.840 76.234 71.624 1.00 32.72 ? 227 TYR B CE1 1 ATOM 3773 C CE2 . TYR B 1 161 ? 40.541 76.261 69.239 1.00 30.75 ? 227 TYR B CE2 1 ATOM 3774 C CZ . TYR B 1 161 ? 40.886 75.586 70.400 1.00 38.74 ? 227 TYR B CZ 1 ATOM 3775 O OH . TYR B 1 161 ? 41.306 74.282 70.346 1.00 41.31 ? 227 TYR B OH 1 ATOM 3776 N N . TYR B 1 162 ? 43.078 79.834 71.072 1.00 28.55 ? 228 TYR B N 1 ATOM 3777 C CA . TYR B 1 162 ? 44.371 79.452 70.489 1.00 28.05 ? 228 TYR B CA 1 ATOM 3778 C C . TYR B 1 162 ? 44.570 77.962 70.779 1.00 34.98 ? 228 TYR B C 1 ATOM 3779 O O . TYR B 1 162 ? 44.564 77.549 71.938 1.00 34.48 ? 228 TYR B O 1 ATOM 3780 C CB . TYR B 1 162 ? 45.528 80.274 71.097 1.00 28.12 ? 228 TYR B CB 1 ATOM 3781 C CG . TYR B 1 162 ? 45.756 81.655 70.509 1.00 28.39 ? 228 TYR B CG 1 ATOM 3782 C CD1 . TYR B 1 162 ? 45.013 82.109 69.421 1.00 29.34 ? 228 TYR B CD1 1 ATOM 3783 C CD2 . TYR B 1 162 ? 46.730 82.505 71.032 1.00 28.28 ? 228 TYR B CD2 1 ATOM 3784 C CE1 . TYR B 1 162 ? 45.224 83.380 68.881 1.00 30.89 ? 228 TYR B CE1 1 ATOM 3785 C CE2 . TYR B 1 162 ? 46.976 83.764 70.474 1.00 27.90 ? 228 TYR B CE2 1 ATOM 3786 C CZ . TYR B 1 162 ? 46.226 84.195 69.395 1.00 34.86 ? 228 TYR B CZ 1 ATOM 3787 O OH . TYR B 1 162 ? 46.466 85.438 68.849 1.00 32.74 ? 228 TYR B OH 1 ATOM 3788 N N . ASN B 1 163 ? 44.683 77.145 69.731 1.00 33.40 ? 229 ASN B N 1 ATOM 3789 C CA . ASN B 1 163 ? 44.886 75.709 69.888 1.00 33.32 ? 229 ASN B CA 1 ATOM 3790 C C . ASN B 1 163 ? 46.366 75.360 70.073 1.00 39.23 ? 229 ASN B C 1 ATOM 3791 O O . ASN B 1 163 ? 47.237 76.197 69.851 1.00 38.43 ? 229 ASN B O 1 ATOM 3792 C CB . ASN B 1 163 ? 44.300 74.976 68.682 1.00 35.49 ? 229 ASN B CB 1 ATOM 3793 C CG . ASN B 1 163 ? 43.968 73.505 68.878 1.00 42.64 ? 229 ASN B CG 1 ATOM 3794 O OD1 . ASN B 1 163 ? 44.254 72.890 69.899 1.00 31.65 ? 229 ASN B OD1 1 ATOM 3795 N ND2 . ASN B 1 163 ? 43.333 72.907 67.903 1.00 33.89 ? 229 ASN B ND2 1 ATOM 3796 N N . ARG B 1 164 ? 46.635 74.125 70.521 1.00 39.56 ? 230 ARG B N 1 ATOM 3797 C CA . ARG B 1 164 ? 47.948 73.501 70.679 1.00 41.13 ? 230 ARG B CA 1 ATOM 3798 C C . ARG B 1 164 ? 48.302 72.938 69.286 1.00 48.59 ? 230 ARG B C 1 ATOM 3799 O O . ARG B 1 164 ? 47.430 72.386 68.619 1.00 48.40 ? 230 ARG B O 1 ATOM 3800 C CB . ARG B 1 164 ? 47.861 72.342 71.705 1.00 42.14 ? 230 ARG B CB 1 ATOM 3801 C CG . ARG B 1 164 ? 47.834 72.779 73.173 1.00 55.75 ? 230 ARG B CG 1 ATOM 3802 C CD . ARG B 1 164 ? 46.449 72.784 73.802 1.00 65.75 ? 230 ARG B CD 1 ATOM 3803 N NE . ARG B 1 164 ? 46.500 73.210 75.202 1.00 77.99 ? 230 ARG B NE 1 ATOM 3804 C CZ . ARG B 1 164 ? 45.476 73.161 76.052 1.00 95.40 ? 230 ARG B CZ 1 ATOM 3805 N NH1 . ARG B 1 164 ? 44.300 72.688 75.662 1.00 86.25 ? 230 ARG B NH1 1 ATOM 3806 N NH2 . ARG B 1 164 ? 45.625 73.571 77.302 1.00 77.67 ? 230 ARG B NH2 1 ATOM 3807 N N . ASP B 1 165 ? 49.544 73.067 68.831 1.00 48.91 ? 231 ASP B N 1 ATOM 3808 C CA . ASP B 1 165 ? 49.919 72.538 67.512 1.00 50.40 ? 231 ASP B CA 1 ATOM 3809 C C . ASP B 1 165 ? 50.030 71.018 67.550 1.00 56.46 ? 231 ASP B C 1 ATOM 3810 O O . ASP B 1 165 ? 50.589 70.459 68.509 1.00 54.28 ? 231 ASP B O 1 ATOM 3811 C CB . ASP B 1 165 ? 51.244 73.144 67.005 1.00 52.84 ? 231 ASP B CB 1 ATOM 3812 C CG . ASP B 1 165 ? 51.512 73.063 65.504 1.00 63.01 ? 231 ASP B CG 1 ATOM 3813 O OD1 . ASP B 1 165 ? 50.639 72.540 64.761 1.00 63.75 ? 231 ASP B OD1 1 ATOM 3814 O OD2 . ASP B 1 165 ? 52.577 73.541 65.070 1.00 68.35 ? 231 ASP B OD2 1 ATOM 3815 N N . SER B 1 166 ? 49.465 70.365 66.496 1.00 55.36 ? 232 SER B N 1 ATOM 3816 C CA . SER B 1 166 ? 49.468 68.909 66.260 1.00 92.86 ? 232 SER B CA 1 ATOM 3817 C C . SER B 1 166 ? 49.375 68.578 64.758 1.00 120.67 ? 232 SER B C 1 ATOM 3818 O O . SER B 1 166 ? 50.156 69.080 63.946 1.00 79.64 ? 232 SER B O 1 ATOM 3819 C CB . SER B 1 166 ? 48.329 68.229 67.016 1.00 95.96 ? 232 SER B CB 1 ATOM 3820 O OG . SER B 1 166 ? 48.775 67.685 68.248 1.00 102.79 ? 232 SER B OG 1 ATOM 3821 N N . SER B 1 169 ? 47.802 65.988 62.952 1.00 74.87 ? 235 SER B N 1 ATOM 3822 C CA . SER B 1 169 ? 46.423 66.272 62.551 1.00 74.65 ? 235 SER B CA 1 ATOM 3823 C C . SER B 1 169 ? 46.264 67.621 61.809 1.00 78.06 ? 235 SER B C 1 ATOM 3824 O O . SER B 1 169 ? 47.192 68.444 61.791 1.00 77.87 ? 235 SER B O 1 ATOM 3825 C CB . SER B 1 169 ? 45.482 66.183 63.755 1.00 78.03 ? 235 SER B CB 1 ATOM 3826 O OG . SER B 1 169 ? 44.121 66.445 63.438 1.00 85.09 ? 235 SER B OG 1 ATOM 3827 N N . GLN B 1 170 ? 45.079 67.815 61.176 1.00 73.56 ? 236 GLN B N 1 ATOM 3828 C CA . GLN B 1 170 ? 44.705 69.012 60.408 1.00 72.67 ? 236 GLN B CA 1 ATOM 3829 C C . GLN B 1 170 ? 43.758 69.889 61.226 1.00 73.08 ? 236 GLN B C 1 ATOM 3830 O O . GLN B 1 170 ? 42.906 70.606 60.667 1.00 72.60 ? 236 GLN B O 1 ATOM 3831 C CB . GLN B 1 170 ? 44.074 68.610 59.058 1.00 74.28 ? 236 GLN B CB 1 ATOM 3832 C CG . GLN B 1 170 ? 44.777 69.175 57.817 1.00 91.54 ? 236 GLN B CG 1 ATOM 3833 C CD . GLN B 1 170 ? 46.288 69.068 57.848 1.00 108.06 ? 236 GLN B CD 1 ATOM 3834 O OE1 . GLN B 1 170 ? 46.988 70.086 57.790 1.00 104.27 ? 236 GLN B OE1 1 ATOM 3835 N NE2 . GLN B 1 170 ? 46.829 67.846 57.965 1.00 93.75 ? 236 GLN B NE2 1 ATOM 3836 N N . SER B 1 171 ? 43.924 69.821 62.574 1.00 65.47 ? 237 SER B N 1 ATOM 3837 C CA . SER B 1 171 ? 43.146 70.566 63.565 1.00 62.30 ? 237 SER B CA 1 ATOM 3838 C C . SER B 1 171 ? 43.185 72.073 63.349 1.00 60.09 ? 237 SER B C 1 ATOM 3839 O O . SER B 1 171 ? 44.157 72.616 62.808 1.00 60.68 ? 237 SER B O 1 ATOM 3840 C CB . SER B 1 171 ? 43.591 70.217 64.985 1.00 64.01 ? 237 SER B CB 1 ATOM 3841 O OG . SER B 1 171 ? 44.968 70.481 65.198 1.00 69.06 ? 237 SER B OG 1 ATOM 3842 N N . LEU B 1 172 ? 42.087 72.726 63.739 1.00 50.49 ? 238 LEU B N 1 ATOM 3843 C CA . LEU B 1 172 ? 41.866 74.162 63.732 1.00 47.29 ? 238 LEU B CA 1 ATOM 3844 C C . LEU B 1 172 ? 42.994 74.847 64.556 1.00 45.03 ? 238 LEU B C 1 ATOM 3845 O O . LEU B 1 172 ? 43.302 74.420 65.669 1.00 43.35 ? 238 LEU B O 1 ATOM 3846 C CB . LEU B 1 172 ? 40.480 74.363 64.374 1.00 47.49 ? 238 LEU B CB 1 ATOM 3847 C CG . LEU B 1 172 ? 40.034 75.744 64.821 1.00 52.73 ? 238 LEU B CG 1 ATOM 3848 C CD1 . LEU B 1 172 ? 39.436 76.504 63.682 1.00 52.76 ? 238 LEU B CD1 1 ATOM 3849 C CD2 . LEU B 1 172 ? 39.000 75.613 65.903 1.00 55.95 ? 238 LEU B CD2 1 ATOM 3850 N N . GLY B 1 173 ? 43.642 75.843 63.969 1.00 37.59 ? 239 GLY B N 1 ATOM 3851 C CA . GLY B 1 173 ? 44.724 76.565 64.633 1.00 35.82 ? 239 GLY B CA 1 ATOM 3852 C C . GLY B 1 173 ? 44.273 77.481 65.760 1.00 37.93 ? 239 GLY B C 1 ATOM 3853 O O . GLY B 1 173 ? 44.966 77.637 66.766 1.00 39.49 ? 239 GLY B O 1 ATOM 3854 N N . GLY B 1 174 ? 43.106 78.076 65.580 1.00 31.10 ? 240 GLY B N 1 ATOM 3855 C CA . GLY B 1 174 ? 42.489 79.001 66.506 1.00 29.68 ? 240 GLY B CA 1 ATOM 3856 C C . GLY B 1 174 ? 41.279 79.667 65.883 1.00 32.30 ? 240 GLY B C 1 ATOM 3857 O O . GLY B 1 174 ? 40.888 79.350 64.754 1.00 30.00 ? 240 GLY B O 1 ATOM 3858 N N . GLN B 1 175 ? 40.670 80.580 66.627 1.00 29.25 ? 241 GLN B N 1 ATOM 3859 C CA . GLN B 1 175 ? 39.467 81.274 66.194 1.00 29.26 ? 241 GLN B CA 1 ATOM 3860 C C . GLN B 1 175 ? 39.244 82.533 67.009 1.00 34.34 ? 241 GLN B C 1 ATOM 3861 O O . GLN B 1 175 ? 39.379 82.515 68.234 1.00 33.40 ? 241 GLN B O 1 ATOM 3862 C CB . GLN B 1 175 ? 38.258 80.343 66.351 1.00 30.21 ? 241 GLN B CB 1 ATOM 3863 C CG . GLN B 1 175 ? 36.930 80.869 65.795 1.00 34.02 ? 241 GLN B CG 1 ATOM 3864 C CD . GLN B 1 175 ? 35.763 80.212 66.494 1.00 51.32 ? 241 GLN B CD 1 ATOM 3865 O OE1 . GLN B 1 175 ? 35.694 80.132 67.733 1.00 42.00 ? 241 GLN B OE1 1 ATOM 3866 N NE2 . GLN B 1 175 ? 34.834 79.701 65.715 1.00 51.36 ? 241 GLN B NE2 1 ATOM 3867 N N . ILE B 1 176 ? 38.893 83.618 66.312 1.00 32.53 ? 242 ILE B N 1 ATOM 3868 C CA . ILE B 1 176 ? 38.496 84.898 66.891 1.00 32.41 ? 242 ILE B CA 1 ATOM 3869 C C . ILE B 1 176 ? 37.019 85.065 66.616 1.00 36.06 ? 242 ILE B C 1 ATOM 3870 O O . ILE B 1 176 ? 36.550 84.778 65.502 1.00 35.31 ? 242 ILE B O 1 ATOM 3871 C CB . ILE B 1 176 ? 39.346 86.137 66.470 1.00 36.01 ? 242 ILE B CB 1 ATOM 3872 C CG1 . ILE B 1 176 ? 38.749 87.471 67.028 1.00 35.69 ? 242 ILE B CG1 1 ATOM 3873 C CG2 . ILE B 1 176 ? 39.593 86.213 64.962 1.00 38.51 ? 242 ILE B CG2 1 ATOM 3874 C CD1 . ILE B 1 176 ? 39.626 88.789 66.840 1.00 32.75 ? 242 ILE B CD1 1 ATOM 3875 N N . VAL B 1 177 ? 36.266 85.453 67.653 1.00 31.18 ? 243 VAL B N 1 ATOM 3876 C CA . VAL B 1 177 ? 34.835 85.706 67.508 1.00 29.78 ? 243 VAL B CA 1 ATOM 3877 C C . VAL B 1 177 ? 34.619 87.180 67.813 1.00 34.13 ? 243 VAL B C 1 ATOM 3878 O O . VAL B 1 177 ? 34.935 87.614 68.905 1.00 34.92 ? 243 VAL B O 1 ATOM 3879 C CB . VAL B 1 177 ? 33.882 84.788 68.367 1.00 31.05 ? 243 VAL B CB 1 ATOM 3880 C CG1 . VAL B 1 177 ? 32.412 85.048 68.025 1.00 29.35 ? 243 VAL B CG1 1 ATOM 3881 C CG2 . VAL B 1 177 ? 34.200 83.316 68.187 1.00 30.09 ? 243 VAL B CG2 1 ATOM 3882 N N . LEU B 1 178 ? 34.074 87.931 66.863 1.00 31.16 ? 244 LEU B N 1 ATOM 3883 C CA . LEU B 1 178 ? 33.700 89.329 67.047 1.00 32.65 ? 244 LEU B CA 1 ATOM 3884 C C . LEU B 1 178 ? 32.226 89.344 67.447 1.00 36.74 ? 244 LEU B C 1 ATOM 3885 O O . LEU B 1 178 ? 31.425 88.721 66.764 1.00 36.42 ? 244 LEU B O 1 ATOM 3886 C CB . LEU B 1 178 ? 33.858 90.136 65.736 1.00 33.44 ? 244 LEU B CB 1 ATOM 3887 C CG . LEU B 1 178 ? 35.216 90.123 65.034 1.00 37.85 ? 244 LEU B CG 1 ATOM 3888 C CD1 . LEU B 1 178 ? 35.118 90.882 63.730 1.00 38.08 ? 244 LEU B CD1 1 ATOM 3889 C CD2 . LEU B 1 178 ? 36.314 90.674 65.927 1.00 37.26 ? 244 LEU B CD2 1 ATOM 3890 N N . GLY B 1 179 ? 31.883 90.043 68.530 1.00 33.20 ? 245 GLY B N 1 ATOM 3891 C CA . GLY B 1 179 ? 30.499 90.146 68.999 1.00 32.61 ? 245 GLY B CA 1 ATOM 3892 C C . GLY B 1 179 ? 30.067 89.128 70.040 1.00 35.01 ? 245 GLY B C 1 ATOM 3893 O O . GLY B 1 179 ? 28.928 89.162 70.497 1.00 35.08 ? 245 GLY B O 1 ATOM 3894 N N . GLY B 1 180 ? 30.965 88.242 70.439 1.00 30.77 ? 246 GLY B N 1 ATOM 3895 C CA . GLY B 1 180 ? 30.646 87.224 71.440 1.00 30.43 ? 246 GLY B CA 1 ATOM 3896 C C . GLY B 1 180 ? 31.753 86.228 71.688 1.00 32.84 ? 246 GLY B C 1 ATOM 3897 O O . GLY B 1 180 ? 32.931 86.526 71.450 1.00 31.68 ? 246 GLY B O 1 ATOM 3898 N N . SER B 1 181 ? 31.360 85.019 72.107 1.00 29.20 ? 247 SER B N 1 ATOM 3899 C CA . SER B 1 181 ? 32.267 83.906 72.414 1.00 29.04 ? 247 SER B CA 1 ATOM 3900 C C . SER B 1 181 ? 31.754 82.612 71.819 1.00 34.58 ? 247 SER B C 1 ATOM 3901 O O . SER B 1 181 ? 30.562 82.508 71.550 1.00 35.39 ? 247 SER B O 1 ATOM 3902 C CB . SER B 1 181 ? 32.437 83.757 73.918 1.00 31.71 ? 247 SER B CB 1 ATOM 3903 O OG . SER B 1 181 ? 31.244 83.238 74.480 1.00 49.86 ? 247 SER B OG 1 ATOM 3904 N N . ASP B 1 182 ? 32.641 81.628 71.599 1.00 32.27 ? 248 ASP B N 1 ATOM 3905 C CA . ASP B 1 182 ? 32.241 80.334 71.052 1.00 32.86 ? 248 ASP B CA 1 ATOM 3906 C C . ASP B 1 182 ? 32.266 79.289 72.168 1.00 35.97 ? 248 ASP B C 1 ATOM 3907 O O . ASP B 1 182 ? 33.359 78.877 72.546 1.00 34.26 ? 248 ASP B O 1 ATOM 3908 C CB . ASP B 1 182 ? 33.124 79.897 69.865 1.00 34.79 ? 248 ASP B CB 1 ATOM 3909 C CG . ASP B 1 182 ? 32.598 78.667 69.120 1.00 40.96 ? 248 ASP B CG 1 ATOM 3910 O OD1 . ASP B 1 182 ? 31.669 78.005 69.635 1.00 39.87 ? 248 ASP B OD1 1 ATOM 3911 O OD2 . ASP B 1 182 ? 33.079 78.401 68.002 1.00 45.55 ? 248 ASP B OD2 1 ATOM 3912 N N . PRO B 1 183 ? 31.075 78.834 72.675 1.00 33.05 ? 249 PRO B N 1 ATOM 3913 C CA . PRO B 1 183 ? 31.061 77.841 73.778 1.00 32.99 ? 249 PRO B CA 1 ATOM 3914 C C . PRO B 1 183 ? 31.690 76.495 73.422 1.00 35.44 ? 249 PRO B C 1 ATOM 3915 O O . PRO B 1 183 ? 32.036 75.743 74.312 1.00 33.65 ? 249 PRO B O 1 ATOM 3916 C CB . PRO B 1 183 ? 29.570 77.734 74.177 1.00 34.52 ? 249 PRO B CB 1 ATOM 3917 C CG . PRO B 1 183 ? 28.896 78.897 73.521 1.00 38.61 ? 249 PRO B CG 1 ATOM 3918 C CD . PRO B 1 183 ? 29.702 79.235 72.302 1.00 33.93 ? 249 PRO B CD 1 ATOM 3919 N N . GLN B 1 184 ? 31.888 76.216 72.128 1.00 34.43 ? 250 GLN B N 1 ATOM 3920 C CA . GLN B 1 184 ? 32.535 74.984 71.659 1.00 34.33 ? 250 GLN B CA 1 ATOM 3921 C C . GLN B 1 184 ? 34.021 74.938 72.021 1.00 36.56 ? 250 GLN B C 1 ATOM 3922 O O . GLN B 1 184 ? 34.602 73.843 72.056 1.00 33.68 ? 250 GLN B O 1 ATOM 3923 C CB . GLN B 1 184 ? 32.357 74.822 70.135 1.00 35.88 ? 250 GLN B CB 1 ATOM 3924 C CG . GLN B 1 184 ? 30.978 74.306 69.705 1.00 67.02 ? 250 GLN B CG 1 ATOM 3925 C CD . GLN B 1 184 ? 30.567 73.000 70.365 1.00 103.05 ? 250 GLN B CD 1 ATOM 3926 O OE1 . GLN B 1 184 ? 29.768 72.975 71.314 1.00 102.39 ? 250 GLN B OE1 1 ATOM 3927 N NE2 . GLN B 1 184 ? 31.100 71.886 69.877 1.00 99.11 ? 250 GLN B NE2 1 ATOM 3928 N N . HIS B 1 185 ? 34.634 76.128 72.315 1.00 33.52 ? 251 HIS B N 1 ATOM 3929 C CA . HIS B 1 185 ? 36.061 76.201 72.615 1.00 32.99 ? 251 HIS B CA 1 ATOM 3930 C C . HIS B 1 185 ? 36.391 76.482 74.067 1.00 34.72 ? 251 HIS B C 1 ATOM 3931 O O . HIS B 1 185 ? 37.562 76.572 74.417 1.00 34.77 ? 251 HIS B O 1 ATOM 3932 C CB . HIS B 1 185 ? 36.760 77.161 71.663 1.00 33.94 ? 251 HIS B CB 1 ATOM 3933 C CG . HIS B 1 185 ? 36.681 76.621 70.271 1.00 37.25 ? 251 HIS B CG 1 ATOM 3934 N ND1 . HIS B 1 185 ? 37.200 75.367 69.957 1.00 38.96 ? 251 HIS B ND1 1 ATOM 3935 C CD2 . HIS B 1 185 ? 36.020 77.101 69.197 1.00 38.34 ? 251 HIS B CD2 1 ATOM 3936 C CE1 . HIS B 1 185 ? 36.877 75.153 68.696 1.00 38.02 ? 251 HIS B CE1 1 ATOM 3937 N NE2 . HIS B 1 185 ? 36.167 76.164 68.196 1.00 38.44 ? 251 HIS B NE2 1 ATOM 3938 N N . TYR B 1 186 ? 35.394 76.458 74.928 1.00 30.47 ? 252 TYR B N 1 ATOM 3939 C CA . TYR B 1 186 ? 35.642 76.595 76.349 1.00 30.84 ? 252 TYR B CA 1 ATOM 3940 C C . TYR B 1 186 ? 34.658 75.808 77.195 1.00 36.80 ? 252 TYR B C 1 ATOM 3941 O O . TYR B 1 186 ? 33.584 75.404 76.731 1.00 34.28 ? 252 TYR B O 1 ATOM 3942 C CB . TYR B 1 186 ? 35.715 78.066 76.790 1.00 31.10 ? 252 TYR B CB 1 ATOM 3943 C CG . TYR B 1 186 ? 34.390 78.788 76.759 1.00 32.34 ? 252 TYR B CG 1 ATOM 3944 C CD1 . TYR B 1 186 ? 33.574 78.845 77.890 1.00 34.56 ? 252 TYR B CD1 1 ATOM 3945 C CD2 . TYR B 1 186 ? 33.974 79.469 75.623 1.00 32.55 ? 252 TYR B CD2 1 ATOM 3946 C CE1 . TYR B 1 186 ? 32.357 79.539 77.874 1.00 34.85 ? 252 TYR B CE1 1 ATOM 3947 C CE2 . TYR B 1 186 ? 32.800 80.222 75.619 1.00 32.96 ? 252 TYR B CE2 1 ATOM 3948 C CZ . TYR B 1 186 ? 31.982 80.239 76.736 1.00 36.61 ? 252 TYR B CZ 1 ATOM 3949 O OH . TYR B 1 186 ? 30.799 80.942 76.681 1.00 37.28 ? 252 TYR B OH 1 ATOM 3950 N N . GLU B 1 187 ? 35.000 75.645 78.465 1.00 37.00 ? 253 GLU B N 1 ATOM 3951 C CA . GLU B 1 187 ? 34.087 74.975 79.371 1.00 39.08 ? 253 GLU B CA 1 ATOM 3952 C C . GLU B 1 187 ? 33.935 75.740 80.651 1.00 41.73 ? 253 GLU B C 1 ATOM 3953 O O . GLU B 1 187 ? 34.772 76.584 81.016 1.00 41.68 ? 253 GLU B O 1 ATOM 3954 C CB . GLU B 1 187 ? 34.435 73.498 79.592 1.00 41.54 ? 253 GLU B CB 1 ATOM 3955 C CG . GLU B 1 187 ? 35.869 73.225 79.972 1.00 54.34 ? 253 GLU B CG 1 ATOM 3956 C CD . GLU B 1 187 ? 36.262 71.765 79.870 1.00 84.69 ? 253 GLU B CD 1 ATOM 3957 O OE1 . GLU B 1 187 ? 35.486 70.958 79.306 1.00 96.36 ? 253 GLU B OE1 1 ATOM 3958 O OE2 . GLU B 1 187 ? 37.368 71.430 80.348 1.00 76.92 ? 253 GLU B OE2 1 ATOM 3959 N N . GLY B 1 188 ? 32.796 75.487 81.273 1.00 36.41 ? 254 GLY B N 1 ATOM 3960 C CA . GLY B 1 188 ? 32.406 76.159 82.493 1.00 35.15 ? 254 GLY B CA 1 ATOM 3961 C C . GLY B 1 188 ? 32.047 77.582 82.187 1.00 38.29 ? 254 GLY B C 1 ATOM 3962 O O . GLY B 1 188 ? 31.663 77.902 81.053 1.00 38.44 ? 254 GLY B O 1 ATOM 3963 N N . ASN B 1 189 ? 32.197 78.446 83.184 1.00 35.64 ? 255 ASN B N 1 ATOM 3964 C CA . ASN B 1 189 ? 31.868 79.851 83.002 1.00 35.49 ? 255 ASN B CA 1 ATOM 3965 C C . ASN B 1 189 ? 33.076 80.750 83.099 1.00 38.11 ? 255 ASN B C 1 ATOM 3966 O O . ASN B 1 189 ? 34.114 80.387 83.654 1.00 40.85 ? 255 ASN B O 1 ATOM 3967 C CB . ASN B 1 189 ? 30.763 80.311 83.976 1.00 34.37 ? 255 ASN B CB 1 ATOM 3968 C CG . ASN B 1 189 ? 29.460 79.586 83.799 1.00 46.19 ? 255 ASN B CG 1 ATOM 3969 O OD1 . ASN B 1 189 ? 29.102 78.727 84.597 1.00 36.95 ? 255 ASN B OD1 1 ATOM 3970 N ND2 . ASN B 1 189 ? 28.733 79.888 82.731 1.00 48.35 ? 255 ASN B ND2 1 ATOM 3971 N N . PHE B 1 190 ? 32.914 81.932 82.548 1.00 32.10 ? 256 PHE B N 1 ATOM 3972 C CA . PHE B 1 190 ? 33.887 83.002 82.554 1.00 31.56 ? 256 PHE B CA 1 ATOM 3973 C C . PHE B 1 190 ? 33.935 83.640 83.930 1.00 34.62 ? 256 PHE B C 1 ATOM 3974 O O . PHE B 1 190 ? 32.908 83.771 84.603 1.00 33.41 ? 256 PHE B O 1 ATOM 3975 C CB . PHE B 1 190 ? 33.463 84.095 81.530 1.00 33.53 ? 256 PHE B CB 1 ATOM 3976 C CG . PHE B 1 190 ? 33.801 83.824 80.086 1.00 34.59 ? 256 PHE B CG 1 ATOM 3977 C CD1 . PHE B 1 190 ? 35.125 83.793 79.660 1.00 36.67 ? 256 PHE B CD1 1 ATOM 3978 C CD2 . PHE B 1 190 ? 32.800 83.627 79.146 1.00 36.24 ? 256 PHE B CD2 1 ATOM 3979 C CE1 . PHE B 1 190 ? 35.444 83.518 78.329 1.00 35.96 ? 256 PHE B CE1 1 ATOM 3980 C CE2 . PHE B 1 190 ? 33.122 83.388 77.803 1.00 37.74 ? 256 PHE B CE2 1 ATOM 3981 C CZ . PHE B 1 190 ? 34.442 83.332 77.410 1.00 35.15 ? 256 PHE B CZ 1 ATOM 3982 N N . HIS B 1 191 ? 35.121 84.035 84.340 1.00 32.37 ? 257 HIS B N 1 ATOM 3983 C CA . HIS B 1 191 ? 35.355 84.840 85.530 1.00 32.61 ? 257 HIS B CA 1 ATOM 3984 C C . HIS B 1 191 ? 36.149 86.012 84.953 1.00 33.94 ? 257 HIS B C 1 ATOM 3985 O O . HIS B 1 191 ? 37.063 85.830 84.122 1.00 31.54 ? 257 HIS B O 1 ATOM 3986 C CB . HIS B 1 191 ? 36.079 84.109 86.682 1.00 33.99 ? 257 HIS B CB 1 ATOM 3987 C CG . HIS B 1 191 ? 36.540 85.041 87.771 1.00 39.13 ? 257 HIS B CG 1 ATOM 3988 N ND1 . HIS B 1 191 ? 35.676 85.467 88.790 1.00 41.50 ? 257 HIS B ND1 1 ATOM 3989 C CD2 . HIS B 1 191 ? 37.743 85.660 87.939 1.00 41.26 ? 257 HIS B CD2 1 ATOM 3990 C CE1 . HIS B 1 191 ? 36.383 86.317 89.529 1.00 40.73 ? 257 HIS B CE1 1 ATOM 3991 N NE2 . HIS B 1 191 ? 37.622 86.479 89.046 1.00 40.76 ? 257 HIS B NE2 1 ATOM 3992 N N . TYR B 1 192 ? 35.730 87.218 85.335 1.00 29.34 ? 258 TYR B N 1 ATOM 3993 C CA . TYR B 1 192 ? 36.281 88.466 84.829 1.00 27.79 ? 258 TYR B CA 1 ATOM 3994 C C . TYR B 1 192 ? 37.152 89.206 85.819 1.00 33.31 ? 258 TYR B C 1 ATOM 3995 O O . TYR B 1 192 ? 36.985 89.085 87.033 1.00 33.66 ? 258 TYR B O 1 ATOM 3996 C CB . TYR B 1 192 ? 35.141 89.348 84.363 1.00 27.90 ? 258 TYR B CB 1 ATOM 3997 C CG . TYR B 1 192 ? 34.267 88.717 83.297 1.00 28.20 ? 258 TYR B CG 1 ATOM 3998 C CD1 . TYR B 1 192 ? 33.212 87.874 83.635 1.00 29.35 ? 258 TYR B CD1 1 ATOM 3999 C CD2 . TYR B 1 192 ? 34.468 88.999 81.951 1.00 28.51 ? 258 TYR B CD2 1 ATOM 4000 C CE1 . TYR B 1 192 ? 32.393 87.308 82.652 1.00 28.80 ? 258 TYR B CE1 1 ATOM 4001 C CE2 . TYR B 1 192 ? 33.673 88.422 80.964 1.00 28.05 ? 258 TYR B CE2 1 ATOM 4002 C CZ . TYR B 1 192 ? 32.632 87.586 81.319 1.00 32.05 ? 258 TYR B CZ 1 ATOM 4003 O OH . TYR B 1 192 ? 31.845 87.035 80.347 1.00 30.73 ? 258 TYR B OH 1 ATOM 4004 N N . ILE B 1 193 ? 38.124 89.940 85.279 1.00 31.09 ? 259 ILE B N 1 ATOM 4005 C CA . ILE B 1 193 ? 39.075 90.805 85.979 1.00 30.85 ? 259 ILE B CA 1 ATOM 4006 C C . ILE B 1 193 ? 38.947 92.149 85.279 1.00 36.04 ? 259 ILE B C 1 ATOM 4007 O O . ILE B 1 193 ? 39.025 92.205 84.051 1.00 35.80 ? 259 ILE B O 1 ATOM 4008 C CB . ILE B 1 193 ? 40.534 90.278 85.943 1.00 33.00 ? 259 ILE B CB 1 ATOM 4009 C CG1 . ILE B 1 193 ? 40.622 88.801 86.429 1.00 33.60 ? 259 ILE B CG1 1 ATOM 4010 C CG2 . ILE B 1 193 ? 41.470 91.164 86.752 1.00 30.67 ? 259 ILE B CG2 1 ATOM 4011 C CD1 . ILE B 1 193 ? 40.638 87.766 85.335 1.00 24.68 ? 259 ILE B CD1 1 ATOM 4012 N N . ASN B 1 194 ? 38.688 93.214 86.039 1.00 33.06 ? 260 ASN B N 1 ATOM 4013 C CA . ASN B 1 194 ? 38.533 94.541 85.454 1.00 33.24 ? 260 ASN B CA 1 ATOM 4014 C C . ASN B 1 194 ? 39.860 95.104 84.999 1.00 36.84 ? 260 ASN B C 1 ATOM 4015 O O . ASN B 1 194 ? 40.903 94.714 85.528 1.00 36.32 ? 260 ASN B O 1 ATOM 4016 C CB . ASN B 1 194 ? 37.842 95.504 86.434 1.00 32.59 ? 260 ASN B CB 1 ATOM 4017 C CG . ASN B 1 194 ? 36.461 95.106 86.882 1.00 49.68 ? 260 ASN B CG 1 ATOM 4018 O OD1 . ASN B 1 194 ? 36.061 95.477 87.970 1.00 57.74 ? 260 ASN B OD1 1 ATOM 4019 N ND2 . ASN B 1 194 ? 35.677 94.356 86.093 1.00 34.39 ? 260 ASN B ND2 1 ATOM 4020 N N . LEU B 1 195 ? 39.823 96.016 84.021 1.00 32.82 ? 261 LEU B N 1 ATOM 4021 C CA . LEU B 1 195 ? 41.040 96.671 83.546 1.00 33.03 ? 261 LEU B CA 1 ATOM 4022 C C . LEU B 1 195 ? 41.495 97.686 84.593 1.00 39.59 ? 261 LEU B C 1 ATOM 4023 O O . LEU B 1 195 ? 40.652 98.300 85.248 1.00 38.63 ? 261 LEU B O 1 ATOM 4024 C CB . LEU B 1 195 ? 40.807 97.392 82.187 1.00 32.16 ? 261 LEU B CB 1 ATOM 4025 C CG . LEU B 1 195 ? 40.409 96.512 80.966 1.00 35.26 ? 261 LEU B CG 1 ATOM 4026 C CD1 . LEU B 1 195 ? 40.332 97.340 79.700 1.00 33.74 ? 261 LEU B CD1 1 ATOM 4027 C CD2 . LEU B 1 195 ? 41.346 95.340 80.768 1.00 33.63 ? 261 LEU B CD2 1 ATOM 4028 N N . ILE B 1 196 ? 42.817 97.870 84.739 1.00 39.36 ? 262 ILE B N 1 ATOM 4029 C CA . ILE B 1 196 ? 43.393 98.900 85.608 1.00 41.83 ? 262 ILE B CA 1 ATOM 4030 C C . ILE B 1 196 ? 42.742 100.246 85.175 1.00 46.59 ? 262 ILE B C 1 ATOM 4031 O O . ILE B 1 196 ? 42.212 100.979 86.000 1.00 48.94 ? 262 ILE B O 1 ATOM 4032 C CB . ILE B 1 196 ? 44.949 98.939 85.417 1.00 46.06 ? 262 ILE B CB 1 ATOM 4033 C CG1 . ILE B 1 196 ? 45.647 97.678 85.984 1.00 45.96 ? 262 ILE B CG1 1 ATOM 4034 C CG2 . ILE B 1 196 ? 45.578 100.251 85.956 1.00 47.64 ? 262 ILE B CG2 1 ATOM 4035 C CD1 . ILE B 1 196 ? 45.650 97.537 87.417 1.00 59.69 ? 262 ILE B CD1 1 ATOM 4036 N N . LYS B 1 197 ? 42.737 100.505 83.862 1.00 41.38 ? 263 LYS B N 1 ATOM 4037 C CA . LYS B 1 197 ? 42.182 101.687 83.213 1.00 40.06 ? 263 LYS B CA 1 ATOM 4038 C C . LYS B 1 197 ? 41.833 101.345 81.775 1.00 44.83 ? 263 LYS B C 1 ATOM 4039 O O . LYS B 1 197 ? 42.486 100.481 81.155 1.00 44.68 ? 263 LYS B O 1 ATOM 4040 C CB . LYS B 1 197 ? 43.198 102.853 83.219 1.00 40.78 ? 263 LYS B CB 1 ATOM 4041 C CG . LYS B 1 197 ? 44.510 102.563 82.483 1.00 45.83 ? 263 LYS B CG 1 ATOM 4042 C CD . LYS B 1 197 ? 45.408 103.791 82.385 1.00 56.05 ? 263 LYS B CD 1 ATOM 4043 C CE . LYS B 1 197 ? 46.765 103.455 81.818 1.00 63.90 ? 263 LYS B CE 1 ATOM 4044 N NZ . LYS B 1 197 ? 47.550 102.597 82.746 1.00 72.74 ? 263 LYS B NZ 1 ATOM 4045 N N . THR B 1 198 ? 40.838 102.070 81.224 1.00 40.73 ? 264 THR B N 1 ATOM 4046 C CA . THR B 1 198 ? 40.447 101.944 79.818 1.00 39.77 ? 264 THR B CA 1 ATOM 4047 C C . THR B 1 198 ? 41.647 102.406 78.952 1.00 41.85 ? 264 THR B C 1 ATOM 4048 O O . THR B 1 198 ? 42.501 103.165 79.431 1.00 39.83 ? 264 THR B O 1 ATOM 4049 C CB . THR B 1 198 ? 39.102 102.655 79.570 1.00 45.63 ? 264 THR B CB 1 ATOM 4050 O OG1 . THR B 1 198 ? 38.522 102.193 78.348 1.00 53.52 ? 264 THR B OG1 1 ATOM 4051 C CG2 . THR B 1 198 ? 39.202 104.177 79.602 1.00 38.10 ? 264 THR B CG2 1 ATOM 4052 N N . GLY B 1 199 ? 41.753 101.877 77.743 1.00 38.26 ? 265 GLY B N 1 ATOM 4053 C CA . GLY B 1 199 ? 42.842 102.246 76.854 1.00 37.78 ? 265 GLY B CA 1 ATOM 4054 C C . GLY B 1 199 ? 43.933 101.217 76.707 1.00 41.31 ? 265 GLY B C 1 ATOM 4055 O O . GLY B 1 199 ? 44.705 101.297 75.757 1.00 40.19 ? 265 GLY B O 1 ATOM 4056 N N . VAL B 1 200 ? 44.032 100.253 77.646 1.00 39.35 ? 266 VAL B N 1 ATOM 4057 C CA . VAL B 1 200 ? 45.058 99.182 77.630 1.00 38.14 ? 266 VAL B CA 1 ATOM 4058 C C . VAL B 1 200 ? 44.410 97.859 78.087 1.00 40.39 ? 266 VAL B C 1 ATOM 4059 O O . VAL B 1 200 ? 43.739 97.850 79.116 1.00 40.56 ? 266 VAL B O 1 ATOM 4060 C CB . VAL B 1 200 ? 46.316 99.503 78.523 1.00 41.77 ? 266 VAL B CB 1 ATOM 4061 C CG1 . VAL B 1 200 ? 47.516 98.647 78.123 1.00 41.27 ? 266 VAL B CG1 1 ATOM 4062 C CG2 . VAL B 1 200 ? 46.706 100.974 78.479 1.00 41.90 ? 266 VAL B CG2 1 ATOM 4063 N N . TRP B 1 201 ? 44.650 96.735 77.370 1.00 35.82 ? 267 TRP B N 1 ATOM 4064 C CA . TRP B 1 201 ? 44.141 95.411 77.786 1.00 34.15 ? 267 TRP B CA 1 ATOM 4065 C C . TRP B 1 201 ? 45.133 94.866 78.840 1.00 36.19 ? 267 TRP B C 1 ATOM 4066 O O . TRP B 1 201 ? 45.851 93.895 78.608 1.00 33.03 ? 267 TRP B O 1 ATOM 4067 C CB . TRP B 1 201 ? 43.952 94.437 76.599 1.00 31.65 ? 267 TRP B CB 1 ATOM 4068 C CG . TRP B 1 201 ? 42.868 94.816 75.641 1.00 31.19 ? 267 TRP B CG 1 ATOM 4069 C CD1 . TRP B 1 201 ? 43.023 95.235 74.352 1.00 33.68 ? 267 TRP B CD1 1 ATOM 4070 C CD2 . TRP B 1 201 ? 41.452 94.799 75.894 1.00 31.05 ? 267 TRP B CD2 1 ATOM 4071 N NE1 . TRP B 1 201 ? 41.787 95.471 73.777 1.00 33.05 ? 267 TRP B NE1 1 ATOM 4072 C CE2 . TRP B 1 201 ? 40.808 95.225 74.708 1.00 34.06 ? 267 TRP B CE2 1 ATOM 4073 C CE3 . TRP B 1 201 ? 40.659 94.497 77.024 1.00 32.00 ? 267 TRP B CE3 1 ATOM 4074 C CZ2 . TRP B 1 201 ? 39.415 95.317 74.605 1.00 32.62 ? 267 TRP B CZ2 1 ATOM 4075 C CZ3 . TRP B 1 201 ? 39.276 94.612 76.920 1.00 32.42 ? 267 TRP B CZ3 1 ATOM 4076 C CH2 . TRP B 1 201 ? 38.670 95.001 75.720 1.00 32.72 ? 267 TRP B CH2 1 ATOM 4077 N N . GLN B 1 202 ? 45.179 95.563 79.999 1.00 33.92 ? 268 GLN B N 1 ATOM 4078 C CA . GLN B 1 202 ? 46.088 95.306 81.113 1.00 32.62 ? 268 GLN B CA 1 ATOM 4079 C C . GLN B 1 202 ? 45.312 95.249 82.420 1.00 36.73 ? 268 GLN B C 1 ATOM 4080 O O . GLN B 1 202 ? 44.459 96.105 82.684 1.00 37.67 ? 268 GLN B O 1 ATOM 4081 C CB . GLN B 1 202 ? 47.173 96.401 81.147 1.00 32.31 ? 268 GLN B CB 1 ATOM 4082 C CG . GLN B 1 202 ? 48.329 96.107 82.113 1.00 37.75 ? 268 GLN B CG 1 ATOM 4083 C CD . GLN B 1 202 ? 49.405 97.146 82.005 1.00 46.50 ? 268 GLN B CD 1 ATOM 4084 O OE1 . GLN B 1 202 ? 49.140 98.354 82.023 1.00 43.01 ? 268 GLN B OE1 1 ATOM 4085 N NE2 . GLN B 1 202 ? 50.637 96.709 81.847 1.00 38.64 ? 268 GLN B NE2 1 ATOM 4086 N N . ILE B 1 203 ? 45.609 94.233 83.231 1.00 30.79 ? 269 ILE B N 1 ATOM 4087 C CA . ILE B 1 203 ? 44.938 94.001 84.513 1.00 29.71 ? 269 ILE B CA 1 ATOM 4088 C C . ILE B 1 203 ? 45.962 93.917 85.645 1.00 36.62 ? 269 ILE B C 1 ATOM 4089 O O . ILE B 1 203 ? 47.166 93.725 85.400 1.00 37.37 ? 269 ILE B O 1 ATOM 4090 C CB . ILE B 1 203 ? 44.052 92.698 84.448 1.00 31.48 ? 269 ILE B CB 1 ATOM 4091 C CG1 . ILE B 1 203 ? 44.912 91.419 84.163 1.00 29.92 ? 269 ILE B CG1 1 ATOM 4092 C CG2 . ILE B 1 203 ? 42.880 92.859 83.462 1.00 31.75 ? 269 ILE B CG2 1 ATOM 4093 C CD1 . ILE B 1 203 ? 44.144 90.062 84.010 1.00 33.36 ? 269 ILE B CD1 1 ATOM 4094 N N . GLN B 1 204 ? 45.472 94.015 86.887 1.00 33.81 ? 270 GLN B N 1 ATOM 4095 C CA . GLN B 1 204 ? 46.276 93.855 88.095 1.00 33.33 ? 270 GLN B CA 1 ATOM 4096 C C . GLN B 1 204 ? 46.480 92.373 88.332 1.00 35.41 ? 270 GLN B C 1 ATOM 4097 O O . GLN B 1 204 ? 45.532 91.588 88.235 1.00 34.17 ? 270 GLN B O 1 ATOM 4098 C CB . GLN B 1 204 ? 45.550 94.483 89.314 1.00 34.72 ? 270 GLN B CB 1 ATOM 4099 C CG . GLN B 1 204 ? 46.363 94.578 90.622 1.00 41.16 ? 270 GLN B CG 1 ATOM 4100 C CD . GLN B 1 204 ? 47.603 95.452 90.561 1.00 59.02 ? 270 GLN B CD 1 ATOM 4101 O OE1 . GLN B 1 204 ? 47.655 96.496 89.894 1.00 53.37 ? 270 GLN B OE1 1 ATOM 4102 N NE2 . GLN B 1 204 ? 48.624 95.056 91.298 1.00 52.87 ? 270 GLN B NE2 1 ATOM 4103 N N . MET B 1 205 ? 47.716 91.988 88.626 1.00 34.51 ? 271 MET B N 1 ATOM 4104 C CA . MET B 1 205 ? 48.055 90.614 88.983 1.00 35.90 ? 271 MET B CA 1 ATOM 4105 C C . MET B 1 205 ? 48.482 90.645 90.467 1.00 45.49 ? 271 MET B C 1 ATOM 4106 O O . MET B 1 205 ? 49.325 91.464 90.854 1.00 44.60 ? 271 MET B O 1 ATOM 4107 C CB . MET B 1 205 ? 49.128 90.028 88.057 1.00 37.90 ? 271 MET B CB 1 ATOM 4108 C CG . MET B 1 205 ? 49.442 88.566 88.360 1.00 40.34 ? 271 MET B CG 1 ATOM 4109 S SD . MET B 1 205 ? 50.055 87.608 86.943 1.00 42.75 ? 271 MET B SD 1 ATOM 4110 C CE . MET B 1 205 ? 51.424 88.552 86.459 1.00 38.71 ? 271 MET B CE 1 ATOM 4111 N N . LYS B 1 206 ? 47.839 89.793 91.299 1.00 45.76 ? 272 LYS B N 1 ATOM 4112 C CA . LYS B 1 206 ? 48.022 89.737 92.753 1.00 46.99 ? 272 LYS B CA 1 ATOM 4113 C C . LYS B 1 206 ? 49.252 88.967 93.208 1.00 51.78 ? 272 LYS B C 1 ATOM 4114 O O . LYS B 1 206 ? 49.741 89.236 94.297 1.00 53.96 ? 272 LYS B O 1 ATOM 4115 C CB . LYS B 1 206 ? 46.754 89.195 93.448 1.00 51.07 ? 272 LYS B CB 1 ATOM 4116 N N . GLY B 1 207 ? 49.747 88.054 92.382 1.00 46.92 ? 273 GLY B N 1 ATOM 4117 C CA . GLY B 1 207 ? 50.924 87.243 92.658 1.00 45.41 ? 273 GLY B CA 1 ATOM 4118 C C . GLY B 1 207 ? 51.139 86.128 91.656 1.00 48.00 ? 273 GLY B C 1 ATOM 4119 O O . GLY B 1 207 ? 50.203 85.722 90.961 1.00 46.38 ? 273 GLY B O 1 ATOM 4120 N N . VAL B 1 208 ? 52.390 85.619 91.579 1.00 45.17 ? 274 VAL B N 1 ATOM 4121 C CA . VAL B 1 208 ? 52.804 84.518 90.693 1.00 43.86 ? 274 VAL B CA 1 ATOM 4122 C C . VAL B 1 208 ? 53.453 83.414 91.545 1.00 48.48 ? 274 VAL B C 1 ATOM 4123 O O . VAL B 1 208 ? 54.505 83.646 92.167 1.00 47.87 ? 274 VAL B O 1 ATOM 4124 C CB . VAL B 1 208 ? 53.726 84.973 89.518 1.00 46.66 ? 274 VAL B CB 1 ATOM 4125 C CG1 . VAL B 1 208 ? 53.983 83.811 88.553 1.00 46.44 ? 274 VAL B CG1 1 ATOM 4126 C CG2 . VAL B 1 208 ? 53.133 86.165 88.762 1.00 46.07 ? 274 VAL B CG2 1 ATOM 4127 N N . SER B 1 209 ? 52.818 82.221 91.578 1.00 45.29 ? 275 SER B N 1 ATOM 4128 C CA . SER B 1 209 ? 53.272 81.073 92.375 1.00 45.54 ? 275 SER B CA 1 ATOM 4129 C C . SER B 1 209 ? 53.921 79.973 91.544 1.00 51.74 ? 275 SER B C 1 ATOM 4130 O O . SER B 1 209 ? 53.386 79.573 90.509 1.00 49.80 ? 275 SER B O 1 ATOM 4131 C CB . SER B 1 209 ? 52.123 80.472 93.179 1.00 47.25 ? 275 SER B CB 1 ATOM 4132 O OG . SER B 1 209 ? 51.249 81.468 93.668 1.00 58.12 ? 275 SER B OG 1 ATOM 4133 N N . VAL B 1 210 ? 55.064 79.474 92.015 1.00 51.83 ? 276 VAL B N 1 ATOM 4134 C CA . VAL B 1 210 ? 55.779 78.368 91.394 1.00 53.80 ? 276 VAL B CA 1 ATOM 4135 C C . VAL B 1 210 ? 55.704 77.220 92.428 1.00 64.22 ? 276 VAL B C 1 ATOM 4136 O O . VAL B 1 210 ? 56.339 77.256 93.479 1.00 64.67 ? 276 VAL B O 1 ATOM 4137 C CB . VAL B 1 210 ? 57.212 78.731 90.908 1.00 56.91 ? 276 VAL B CB 1 ATOM 4138 C CG1 . VAL B 1 210 ? 57.776 77.629 90.039 1.00 56.83 ? 276 VAL B CG1 1 ATOM 4139 C CG2 . VAL B 1 210 ? 57.225 80.033 90.114 1.00 56.53 ? 276 VAL B CG2 1 ATOM 4140 N N . GLY B 1 211 ? 54.819 76.278 92.168 1.00 64.90 ? 277 GLY B N 1 ATOM 4141 C CA . GLY B 1 211 ? 54.564 75.179 93.087 1.00 67.12 ? 277 GLY B CA 1 ATOM 4142 C C . GLY B 1 211 ? 53.587 75.620 94.159 1.00 76.41 ? 277 GLY B C 1 ATOM 4143 O O . GLY B 1 211 ? 52.536 76.176 93.828 1.00 75.59 ? 277 GLY B O 1 ATOM 4144 N N . SER B 1 212 ? 53.940 75.452 95.442 1.00 76.81 ? 278 SER B N 1 ATOM 4145 C CA . SER B 1 212 ? 53.086 75.850 96.571 1.00 77.95 ? 278 SER B CA 1 ATOM 4146 C C . SER B 1 212 ? 53.330 77.321 97.008 1.00 83.51 ? 278 SER B C 1 ATOM 4147 O O . SER B 1 212 ? 52.384 78.109 97.124 1.00 82.82 ? 278 SER B O 1 ATOM 4148 C CB . SER B 1 212 ? 53.280 74.887 97.740 1.00 81.64 ? 278 SER B CB 1 ATOM 4149 O OG . SER B 1 212 ? 54.651 74.768 98.098 1.00 88.05 ? 278 SER B OG 1 ATOM 4150 N N . SER B 1 213 ? 54.610 77.676 97.195 1.00 80.41 ? 279 SER B N 1 ATOM 4151 C CA . SER B 1 213 ? 55.079 79.010 97.549 1.00 79.72 ? 279 SER B CA 1 ATOM 4152 C C . SER B 1 213 ? 54.817 80.003 96.391 1.00 82.39 ? 279 SER B C 1 ATOM 4153 O O . SER B 1 213 ? 54.859 79.602 95.223 1.00 82.25 ? 279 SER B O 1 ATOM 4154 C CB . SER B 1 213 ? 56.575 78.959 97.863 1.00 82.98 ? 279 SER B CB 1 ATOM 4155 O OG . SER B 1 213 ? 57.288 78.054 97.029 1.00 87.50 ? 279 SER B OG 1 ATOM 4156 N N . THR B 1 214 ? 54.530 81.288 96.723 1.00 76.76 ? 280 THR B N 1 ATOM 4157 C CA . THR B 1 214 ? 54.335 82.351 95.738 1.00 75.07 ? 280 THR B CA 1 ATOM 4158 C C . THR B 1 214 ? 55.745 82.803 95.317 1.00 76.14 ? 280 THR B C 1 ATOM 4159 O O . THR B 1 214 ? 56.301 82.255 94.360 1.00 76.11 ? 280 THR B O 1 ATOM 4160 C CB . THR B 1 214 ? 53.361 83.439 96.267 1.00 81.06 ? 280 THR B CB 1 ATOM 4161 O OG1 . THR B 1 214 ? 52.084 82.831 96.485 1.00 82.88 ? 280 THR B OG1 1 ATOM 4162 C CG2 . THR B 1 214 ? 53.186 84.625 95.301 1.00 75.29 ? 280 THR B CG2 1 ATOM 4163 N N . LEU B 1 215 ? 56.343 83.726 96.087 1.00 69.81 ? 281 LEU B N 1 ATOM 4164 C CA . LEU B 1 215 ? 57.691 84.277 95.910 1.00 68.29 ? 281 LEU B CA 1 ATOM 4165 C C . LEU B 1 215 ? 57.843 85.190 94.677 1.00 66.24 ? 281 LEU B C 1 ATOM 4166 O O . LEU B 1 215 ? 58.910 85.783 94.513 1.00 66.60 ? 281 LEU B O 1 ATOM 4167 C CB . LEU B 1 215 ? 58.792 83.191 95.939 1.00 68.80 ? 281 LEU B CB 1 ATOM 4168 N N . LEU B 1 216 ? 56.802 85.359 93.853 1.00 58.06 ? 282 LEU B N 1 ATOM 4169 C CA . LEU B 1 216 ? 56.892 86.305 92.742 1.00 56.31 ? 282 LEU B CA 1 ATOM 4170 C C . LEU B 1 216 ? 55.678 87.197 92.697 1.00 55.32 ? 282 LEU B C 1 ATOM 4171 O O . LEU B 1 216 ? 54.569 86.719 92.946 1.00 53.54 ? 282 LEU B O 1 ATOM 4172 C CB . LEU B 1 216 ? 57.102 85.626 91.381 1.00 56.82 ? 282 LEU B CB 1 ATOM 4173 C CG . LEU B 1 216 ? 58.514 85.199 91.017 1.00 62.35 ? 282 LEU B CG 1 ATOM 4174 C CD1 . LEU B 1 216 ? 58.489 84.340 89.773 1.00 62.68 ? 282 LEU B CD1 1 ATOM 4175 C CD2 . LEU B 1 216 ? 59.422 86.411 90.788 1.00 66.13 ? 282 LEU B CD2 1 ATOM 4176 N N . CYS B 1 217 ? 55.874 88.490 92.358 1.00 50.92 ? 283 CYS B N 1 ATOM 4177 C CA . CYS B 1 217 ? 54.788 89.474 92.257 1.00 51.32 ? 283 CYS B CA 1 ATOM 4178 C C . CYS B 1 217 ? 54.019 89.527 93.628 1.00 56.90 ? 283 CYS B C 1 ATOM 4179 O O . CYS B 1 217 ? 52.814 89.778 93.695 1.00 55.93 ? 283 CYS B O 1 ATOM 4180 C CB . CYS B 1 217 ? 53.882 89.120 91.067 1.00 51.50 ? 283 CYS B CB 1 ATOM 4181 S SG . CYS B 1 217 ? 52.490 90.246 90.795 1.00 54.86 ? 283 CYS B SG 1 ATOM 4182 N N . GLU B 1 218 ? 54.780 89.302 94.726 1.00 55.39 ? 284 GLU B N 1 ATOM 4183 C CA . GLU B 1 218 ? 54.347 89.256 96.125 1.00 55.25 ? 284 GLU B CA 1 ATOM 4184 C C . GLU B 1 218 ? 53.600 90.526 96.582 1.00 59.30 ? 284 GLU B C 1 ATOM 4185 O O . GLU B 1 218 ? 52.641 90.423 97.353 1.00 58.09 ? 284 GLU B O 1 ATOM 4186 C CB . GLU B 1 218 ? 55.542 88.936 97.035 1.00 56.46 ? 284 GLU B CB 1 ATOM 4187 N N . ASP B 1 219 ? 54.001 91.709 96.063 1.00 55.82 ? 285 ASP B N 1 ATOM 4188 C CA . ASP B 1 219 ? 53.346 92.976 96.398 1.00 55.89 ? 285 ASP B CA 1 ATOM 4189 C C . ASP B 1 219 ? 52.466 93.519 95.248 1.00 59.45 ? 285 ASP B C 1 ATOM 4190 O O . ASP B 1 219 ? 52.116 94.709 95.228 1.00 58.17 ? 285 ASP B O 1 ATOM 4191 C CB . ASP B 1 219 ? 54.382 94.019 96.871 1.00 58.46 ? 285 ASP B CB 1 ATOM 4192 C CG . ASP B 1 219 ? 55.201 93.601 98.093 1.00 70.38 ? 285 ASP B CG 1 ATOM 4193 O OD1 . ASP B 1 219 ? 54.585 93.183 99.119 1.00 69.87 ? 285 ASP B OD1 1 ATOM 4194 O OD2 . ASP B 1 219 ? 56.454 93.697 98.030 1.00 75.23 ? 285 ASP B OD2 1 ATOM 4195 N N . GLY B 1 220 ? 52.099 92.625 94.320 1.00 55.11 ? 286 GLY B N 1 ATOM 4196 C CA . GLY B 1 220 ? 51.274 92.959 93.165 1.00 53.57 ? 286 GLY B CA 1 ATOM 4197 C C . GLY B 1 220 ? 52.077 93.470 91.988 1.00 55.11 ? 286 GLY B C 1 ATOM 4198 O O . GLY B 1 220 ? 53.173 94.013 92.157 1.00 54.98 ? 286 GLY B O 1 ATOM 4199 N N . CYS B 1 221 ? 51.542 93.259 90.777 1.00 49.86 ? 287 CYS B N 1 ATOM 4200 C CA . CYS B 1 221 ? 52.155 93.655 89.506 1.00 49.16 ? 287 CYS B CA 1 ATOM 4201 C C . CYS B 1 221 ? 51.109 93.791 88.392 1.00 48.95 ? 287 CYS B C 1 ATOM 4202 O O . CYS B 1 221 ? 49.905 93.696 88.648 1.00 47.98 ? 287 CYS B O 1 ATOM 4203 C CB . CYS B 1 221 ? 53.292 92.709 89.112 1.00 50.24 ? 287 CYS B CB 1 ATOM 4204 S SG . CYS B 1 221 ? 52.795 90.980 88.916 1.00 54.67 ? 287 CYS B SG 1 ATOM 4205 N N . LEU B 1 222 ? 51.569 94.067 87.170 1.00 42.29 ? 288 LEU B N 1 ATOM 4206 C CA . LEU B 1 222 ? 50.685 94.247 86.033 1.00 40.73 ? 288 LEU B CA 1 ATOM 4207 C C . LEU B 1 222 ? 50.762 93.067 85.073 1.00 43.45 ? 288 LEU B C 1 ATOM 4208 O O . LEU B 1 222 ? 51.793 92.392 84.984 1.00 42.32 ? 288 LEU B O 1 ATOM 4209 C CB . LEU B 1 222 ? 51.021 95.546 85.291 1.00 40.44 ? 288 LEU B CB 1 ATOM 4210 C CG . LEU B 1 222 ? 51.038 96.846 86.100 1.00 44.38 ? 288 LEU B CG 1 ATOM 4211 C CD1 . LEU B 1 222 ? 51.543 97.992 85.233 1.00 44.38 ? 288 LEU B CD1 1 ATOM 4212 C CD2 . LEU B 1 222 ? 49.632 97.181 86.672 1.00 43.51 ? 288 LEU B CD2 1 ATOM 4213 N N . ALA B 1 223 ? 49.648 92.810 84.375 1.00 39.70 ? 289 ALA B N 1 ATOM 4214 C CA . ALA B 1 223 ? 49.563 91.756 83.374 1.00 38.39 ? 289 ALA B CA 1 ATOM 4215 C C . ALA B 1 223 ? 48.857 92.278 82.116 1.00 38.84 ? 289 ALA B C 1 ATOM 4216 O O . ALA B 1 223 ? 47.654 92.557 82.147 1.00 36.73 ? 289 ALA B O 1 ATOM 4217 C CB . ALA B 1 223 ? 48.860 90.515 83.939 1.00 38.68 ? 289 ALA B CB 1 ATOM 4218 N N . LEU B 1 224 ? 49.629 92.451 81.020 1.00 34.60 ? 290 LEU B N 1 ATOM 4219 C CA . LEU B 1 224 ? 49.066 92.847 79.726 1.00 33.43 ? 290 LEU B CA 1 ATOM 4220 C C . LEU B 1 224 ? 48.591 91.558 79.033 1.00 34.79 ? 290 LEU B C 1 ATOM 4221 O O . LEU B 1 224 ? 49.364 90.613 78.958 1.00 33.13 ? 290 LEU B O 1 ATOM 4222 C CB . LEU B 1 224 ? 50.127 93.564 78.882 1.00 33.41 ? 290 LEU B CB 1 ATOM 4223 C CG . LEU B 1 224 ? 49.664 93.992 77.481 1.00 38.37 ? 290 LEU B CG 1 ATOM 4224 C CD1 . LEU B 1 224 ? 48.800 95.249 77.515 1.00 37.32 ? 290 LEU B CD1 1 ATOM 4225 C CD2 . LEU B 1 224 ? 50.837 94.132 76.536 1.00 40.00 ? 290 LEU B CD2 1 ATOM 4226 N N . VAL B 1 225 ? 47.321 91.480 78.608 1.00 31.00 ? 291 VAL B N 1 ATOM 4227 C CA . VAL B 1 225 ? 46.794 90.269 77.941 1.00 30.37 ? 291 VAL B CA 1 ATOM 4228 C C . VAL B 1 225 ? 46.972 90.497 76.440 1.00 34.16 ? 291 VAL B C 1 ATOM 4229 O O . VAL B 1 225 ? 46.216 91.247 75.815 1.00 34.95 ? 291 VAL B O 1 ATOM 4230 C CB . VAL B 1 225 ? 45.358 89.881 78.394 1.00 32.98 ? 291 VAL B CB 1 ATOM 4231 C CG1 . VAL B 1 225 ? 44.921 88.565 77.768 1.00 32.35 ? 291 VAL B CG1 1 ATOM 4232 C CG2 . VAL B 1 225 ? 45.285 89.784 79.914 1.00 33.00 ? 291 VAL B CG2 1 ATOM 4233 N N . ASP B 1 226 ? 48.051 89.935 75.899 1.00 30.35 ? 292 ASP B N 1 ATOM 4234 C CA . ASP B 1 226 ? 48.505 90.202 74.539 1.00 30.01 ? 292 ASP B CA 1 ATOM 4235 C C . ASP B 1 226 ? 48.357 89.029 73.581 1.00 35.67 ? 292 ASP B C 1 ATOM 4236 O O . ASP B 1 226 ? 49.157 88.091 73.623 1.00 36.54 ? 292 ASP B O 1 ATOM 4237 C CB . ASP B 1 226 ? 49.973 90.694 74.595 1.00 31.11 ? 292 ASP B CB 1 ATOM 4238 C CG . ASP B 1 226 ? 50.513 91.378 73.335 1.00 37.00 ? 292 ASP B CG 1 ATOM 4239 O OD1 . ASP B 1 226 ? 49.751 91.509 72.348 1.00 33.17 ? 292 ASP B OD1 1 ATOM 4240 O OD2 . ASP B 1 226 ? 51.710 91.762 73.333 1.00 39.83 ? 292 ASP B OD2 1 ATOM 4241 N N . THR B 1 227 ? 47.379 89.125 72.663 1.00 32.03 ? 293 THR B N 1 ATOM 4242 C CA . THR B 1 227 ? 47.110 88.094 71.656 1.00 31.97 ? 293 THR B CA 1 ATOM 4243 C C . THR B 1 227 ? 48.191 88.016 70.568 1.00 37.45 ? 293 THR B C 1 ATOM 4244 O O . THR B 1 227 ? 48.363 86.962 69.949 1.00 37.83 ? 293 THR B O 1 ATOM 4245 C CB . THR B 1 227 ? 45.714 88.259 71.080 1.00 33.72 ? 293 THR B CB 1 ATOM 4246 O OG1 . THR B 1 227 ? 45.596 89.547 70.480 1.00 32.04 ? 293 THR B OG1 1 ATOM 4247 C CG2 . THR B 1 227 ? 44.640 88.075 72.132 1.00 28.49 ? 293 THR B CG2 1 ATOM 4248 N N . GLY B 1 228 ? 48.932 89.107 70.392 1.00 34.70 ? 294 GLY B N 1 ATOM 4249 C CA . GLY B 1 228 ? 50.034 89.204 69.442 1.00 34.57 ? 294 GLY B CA 1 ATOM 4250 C C . GLY B 1 228 ? 51.401 88.837 70.004 1.00 38.70 ? 294 GLY B C 1 ATOM 4251 O O . GLY B 1 228 ? 52.396 88.964 69.297 1.00 39.01 ? 294 GLY B O 1 ATOM 4252 N N . ALA B 1 229 ? 51.478 88.382 71.273 1.00 33.60 ? 295 ALA B N 1 ATOM 4253 C CA . ALA B 1 229 ? 52.732 87.955 71.887 1.00 31.53 ? 295 ALA B CA 1 ATOM 4254 C C . ALA B 1 229 ? 52.723 86.442 71.964 1.00 35.44 ? 295 ALA B C 1 ATOM 4255 O O . ALA B 1 229 ? 51.679 85.841 72.247 1.00 35.88 ? 295 ALA B O 1 ATOM 4256 C CB . ALA B 1 229 ? 52.866 88.549 73.268 1.00 31.97 ? 295 ALA B CB 1 ATOM 4257 N N . SER B 1 230 ? 53.874 85.809 71.687 1.00 31.09 ? 296 SER B N 1 ATOM 4258 C CA . SER B 1 230 ? 53.986 84.350 71.661 1.00 29.62 ? 296 SER B CA 1 ATOM 4259 C C . SER B 1 230 ? 53.968 83.693 73.036 1.00 33.61 ? 296 SER B C 1 ATOM 4260 O O . SER B 1 230 ? 53.387 82.632 73.207 1.00 32.43 ? 296 SER B O 1 ATOM 4261 C CB . SER B 1 230 ? 55.255 83.924 70.922 1.00 30.52 ? 296 SER B CB 1 ATOM 4262 O OG . SER B 1 230 ? 55.334 84.470 69.620 1.00 38.05 ? 296 SER B OG 1 ATOM 4263 N N . TYR B 1 231 ? 54.639 84.284 74.006 1.00 32.41 ? 297 TYR B N 1 ATOM 4264 C CA . TYR B 1 231 ? 54.824 83.654 75.301 1.00 32.24 ? 297 TYR B CA 1 ATOM 4265 C C . TYR B 1 231 ? 54.211 84.392 76.452 1.00 37.46 ? 297 TYR B C 1 ATOM 4266 O O . TYR B 1 231 ? 53.592 85.435 76.281 1.00 35.19 ? 297 TYR B O 1 ATOM 4267 C CB . TYR B 1 231 ? 56.346 83.550 75.563 1.00 32.63 ? 297 TYR B CB 1 ATOM 4268 C CG . TYR B 1 231 ? 57.126 83.081 74.363 1.00 35.18 ? 297 TYR B CG 1 ATOM 4269 C CD1 . TYR B 1 231 ? 56.977 81.783 73.871 1.00 37.75 ? 297 TYR B CD1 1 ATOM 4270 C CD2 . TYR B 1 231 ? 57.960 83.950 73.668 1.00 36.07 ? 297 TYR B CD2 1 ATOM 4271 C CE1 . TYR B 1 231 ? 57.681 81.350 72.745 1.00 39.53 ? 297 TYR B CE1 1 ATOM 4272 C CE2 . TYR B 1 231 ? 58.697 83.520 72.565 1.00 36.94 ? 297 TYR B CE2 1 ATOM 4273 C CZ . TYR B 1 231 ? 58.543 82.223 72.097 1.00 46.70 ? 297 TYR B CZ 1 ATOM 4274 O OH . TYR B 1 231 ? 59.272 81.800 71.008 1.00 50.83 ? 297 TYR B OH 1 ATOM 4275 N N . ILE B 1 232 ? 54.417 83.830 77.653 1.00 35.30 ? 298 ILE B N 1 ATOM 4276 C CA . ILE B 1 232 ? 54.146 84.527 78.880 1.00 34.59 ? 298 ILE B CA 1 ATOM 4277 C C . ILE B 1 232 ? 55.510 85.205 79.127 1.00 39.85 ? 298 ILE B C 1 ATOM 4278 O O . ILE B 1 232 ? 56.549 84.539 79.174 1.00 39.15 ? 298 ILE B O 1 ATOM 4279 C CB . ILE B 1 232 ? 53.717 83.643 80.080 1.00 36.23 ? 298 ILE B CB 1 ATOM 4280 C CG1 . ILE B 1 232 ? 52.253 83.168 79.914 1.00 34.52 ? 298 ILE B CG1 1 ATOM 4281 C CG2 . ILE B 1 232 ? 53.905 84.442 81.412 1.00 35.23 ? 298 ILE B CG2 1 ATOM 4282 C CD1 . ILE B 1 232 ? 51.967 81.920 80.514 1.00 33.05 ? 298 ILE B CD1 1 ATOM 4283 N N . SER B 1 233 ? 55.503 86.521 79.242 1.00 36.84 ? 299 SER B N 1 ATOM 4284 C CA . SER B 1 233 ? 56.729 87.217 79.524 1.00 35.80 ? 299 SER B CA 1 ATOM 4285 C C . SER B 1 233 ? 56.641 87.945 80.851 1.00 41.87 ? 299 SER B C 1 ATOM 4286 O O . SER B 1 233 ? 55.558 88.312 81.311 1.00 41.05 ? 299 SER B O 1 ATOM 4287 C CB . SER B 1 233 ? 57.090 88.157 78.380 1.00 35.56 ? 299 SER B CB 1 ATOM 4288 O OG . SER B 1 233 ? 56.240 89.285 78.350 1.00 37.05 ? 299 SER B OG 1 ATOM 4289 N N . GLY B 1 234 ? 57.789 88.070 81.479 1.00 39.33 ? 300 GLY B N 1 ATOM 4290 C CA . GLY B 1 234 ? 58.000 88.839 82.688 1.00 39.65 ? 300 GLY B CA 1 ATOM 4291 C C . GLY B 1 234 ? 59.256 89.654 82.470 1.00 46.42 ? 300 GLY B C 1 ATOM 4292 O O . GLY B 1 234 ? 59.909 89.527 81.430 1.00 46.75 ? 300 GLY B O 1 ATOM 4293 N N . SER B 1 235 ? 59.614 90.485 83.443 1.00 44.04 ? 301 SER B N 1 ATOM 4294 C CA . SER B 1 235 ? 60.845 91.282 83.389 1.00 43.13 ? 301 SER B CA 1 ATOM 4295 C C . SER B 1 235 ? 62.028 90.319 83.532 1.00 49.90 ? 301 SER B C 1 ATOM 4296 O O . SER B 1 235 ? 61.848 89.216 84.062 1.00 50.54 ? 301 SER B O 1 ATOM 4297 C CB . SER B 1 235 ? 60.865 92.313 84.516 1.00 41.00 ? 301 SER B CB 1 ATOM 4298 O OG . SER B 1 235 ? 60.844 91.652 85.768 1.00 40.98 ? 301 SER B OG 1 ATOM 4299 N N . THR B 1 236 ? 63.227 90.727 83.065 1.00 47.57 ? 302 THR B N 1 ATOM 4300 C CA . THR B 1 236 ? 64.455 89.926 83.155 1.00 47.33 ? 302 THR B CA 1 ATOM 4301 C C . THR B 1 236 ? 64.695 89.437 84.589 1.00 52.66 ? 302 THR B C 1 ATOM 4302 O O . THR B 1 236 ? 65.067 88.278 84.774 1.00 53.28 ? 302 THR B O 1 ATOM 4303 C CB . THR B 1 236 ? 65.646 90.709 82.588 1.00 55.04 ? 302 THR B CB 1 ATOM 4304 O OG1 . THR B 1 236 ? 65.336 91.154 81.266 1.00 50.77 ? 302 THR B OG1 1 ATOM 4305 C CG2 . THR B 1 236 ? 66.934 89.885 82.561 1.00 55.68 ? 302 THR B CG2 1 ATOM 4306 N N . SER B 1 237 ? 64.444 90.300 85.599 1.00 49.91 ? 303 SER B N 1 ATOM 4307 C CA . SER B 1 237 ? 64.643 89.944 87.007 1.00 49.94 ? 303 SER B CA 1 ATOM 4308 C C . SER B 1 237 ? 63.663 88.882 87.465 1.00 53.27 ? 303 SER B C 1 ATOM 4309 O O . SER B 1 237 ? 64.105 87.859 87.996 1.00 54.41 ? 303 SER B O 1 ATOM 4310 C CB . SER B 1 237 ? 64.636 91.173 87.919 1.00 54.69 ? 303 SER B CB 1 ATOM 4311 O OG . SER B 1 237 ? 63.469 91.966 87.783 1.00 69.24 ? 303 SER B OG 1 ATOM 4312 N N . SER B 1 238 ? 62.347 89.072 87.186 1.00 47.03 ? 304 SER B N 1 ATOM 4313 C CA . SER B 1 238 ? 61.293 88.107 87.541 1.00 45.01 ? 304 SER B CA 1 ATOM 4314 C C . SER B 1 238 ? 61.546 86.736 86.913 1.00 46.82 ? 304 SER B C 1 ATOM 4315 O O . SER B 1 238 ? 61.421 85.718 87.600 1.00 46.99 ? 304 SER B O 1 ATOM 4316 C CB . SER B 1 238 ? 59.920 88.619 87.118 1.00 46.31 ? 304 SER B CB 1 ATOM 4317 O OG . SER B 1 238 ? 59.686 89.925 87.611 1.00 52.02 ? 304 SER B OG 1 ATOM 4318 N N . ILE B 1 239 ? 61.926 86.712 85.620 1.00 42.04 ? 305 ILE B N 1 ATOM 4319 C CA . ILE B 1 239 ? 62.185 85.474 84.873 1.00 41.12 ? 305 ILE B CA 1 ATOM 4320 C C . ILE B 1 239 ? 63.446 84.779 85.403 1.00 45.08 ? 305 ILE B C 1 ATOM 4321 O O . ILE B 1 239 ? 63.444 83.553 85.500 1.00 44.05 ? 305 ILE B O 1 ATOM 4322 C CB . ILE B 1 239 ? 62.162 85.727 83.341 1.00 43.94 ? 305 ILE B CB 1 ATOM 4323 C CG1 . ILE B 1 239 ? 60.758 86.251 82.894 1.00 44.31 ? 305 ILE B CG1 1 ATOM 4324 C CG2 . ILE B 1 239 ? 62.586 84.481 82.527 1.00 44.46 ? 305 ILE B CG2 1 ATOM 4325 C CD1 . ILE B 1 239 ? 59.453 85.427 83.374 1.00 41.64 ? 305 ILE B CD1 1 ATOM 4326 N N . GLU B 1 240 ? 64.468 85.554 85.847 1.00 42.96 ? 306 GLU B N 1 ATOM 4327 C CA . GLU B 1 240 ? 65.667 84.973 86.467 1.00 43.84 ? 306 GLU B CA 1 ATOM 4328 C C . GLU B 1 240 ? 65.290 84.171 87.740 1.00 47.56 ? 306 GLU B C 1 ATOM 4329 O O . GLU B 1 240 ? 65.681 83.004 87.855 1.00 47.25 ? 306 GLU B O 1 ATOM 4330 C CB . GLU B 1 240 ? 66.740 86.038 86.742 1.00 45.48 ? 306 GLU B CB 1 ATOM 4331 C CG . GLU B 1 240 ? 67.644 86.297 85.540 1.00 56.89 ? 306 GLU B CG 1 ATOM 4332 C CD . GLU B 1 240 ? 68.426 87.603 85.476 1.00 79.57 ? 306 GLU B CD 1 ATOM 4333 O OE1 . GLU B 1 240 ? 68.332 88.421 86.424 1.00 61.94 ? 306 GLU B OE1 1 ATOM 4334 O OE2 . GLU B 1 240 ? 69.142 87.803 84.464 1.00 70.59 ? 306 GLU B OE2 1 ATOM 4335 N N . LYS B 1 241 ? 64.457 84.756 88.631 1.00 44.90 ? 307 LYS B N 1 ATOM 4336 C CA . LYS B 1 241 ? 63.988 84.092 89.859 1.00 44.85 ? 307 LYS B CA 1 ATOM 4337 C C . LYS B 1 241 ? 63.110 82.900 89.534 1.00 50.08 ? 307 LYS B C 1 ATOM 4338 O O . LYS B 1 241 ? 63.302 81.838 90.128 1.00 51.04 ? 307 LYS B O 1 ATOM 4339 C CB . LYS B 1 241 ? 63.254 85.071 90.789 1.00 47.47 ? 307 LYS B CB 1 ATOM 4340 N N . LEU B 1 242 ? 62.161 83.061 88.570 1.00 46.32 ? 308 LEU B N 1 ATOM 4341 C CA . LEU B 1 242 ? 61.249 81.998 88.125 1.00 45.60 ? 308 LEU B CA 1 ATOM 4342 C C . LEU B 1 242 ? 62.015 80.786 87.595 1.00 46.40 ? 308 LEU B C 1 ATOM 4343 O O . LEU B 1 242 ? 61.728 79.653 88.007 1.00 46.89 ? 308 LEU B O 1 ATOM 4344 C CB . LEU B 1 242 ? 60.239 82.516 87.069 1.00 46.05 ? 308 LEU B CB 1 ATOM 4345 C CG . LEU B 1 242 ? 59.299 81.475 86.454 1.00 51.80 ? 308 LEU B CG 1 ATOM 4346 C CD1 . LEU B 1 242 ? 57.868 81.761 86.794 1.00 52.70 ? 308 LEU B CD1 1 ATOM 4347 C CD2 . LEU B 1 242 ? 59.482 81.409 84.967 1.00 55.94 ? 308 LEU B CD2 1 ATOM 4348 N N . MET B 1 243 ? 62.998 81.021 86.716 1.00 39.47 ? 309 MET B N 1 ATOM 4349 C CA . MET B 1 243 ? 63.777 79.942 86.097 1.00 38.54 ? 309 MET B CA 1 ATOM 4350 C C . MET B 1 243 ? 64.709 79.221 87.069 1.00 45.19 ? 309 MET B C 1 ATOM 4351 O O . MET B 1 243 ? 64.953 78.022 86.903 1.00 44.99 ? 309 MET B O 1 ATOM 4352 C CB . MET B 1 243 ? 64.534 80.464 84.871 1.00 40.39 ? 309 MET B CB 1 ATOM 4353 C CG . MET B 1 243 ? 63.621 80.952 83.766 1.00 43.49 ? 309 MET B CG 1 ATOM 4354 S SD . MET B 1 243 ? 62.740 79.622 82.932 1.00 47.60 ? 309 MET B SD 1 ATOM 4355 C CE . MET B 1 243 ? 61.676 80.597 81.896 1.00 43.90 ? 309 MET B CE 1 ATOM 4356 N N . GLU B 1 244 ? 65.218 79.942 88.083 1.00 44.43 ? 310 GLU B N 1 ATOM 4357 C CA . GLU B 1 244 ? 66.063 79.390 89.139 1.00 45.82 ? 310 GLU B CA 1 ATOM 4358 C C . GLU B 1 244 ? 65.218 78.351 89.914 1.00 49.59 ? 310 GLU B C 1 ATOM 4359 O O . GLU B 1 244 ? 65.676 77.232 90.128 1.00 50.19 ? 310 GLU B O 1 ATOM 4360 C CB . GLU B 1 244 ? 66.538 80.526 90.062 1.00 48.12 ? 310 GLU B CB 1 ATOM 4361 C CG . GLU B 1 244 ? 67.619 80.130 91.062 1.00 66.42 ? 310 GLU B CG 1 ATOM 4362 C CD . GLU B 1 244 ? 67.808 81.062 92.253 1.00 106.55 ? 310 GLU B CD 1 ATOM 4363 O OE1 . GLU B 1 244 ? 67.312 82.212 92.209 1.00 105.94 ? 310 GLU B OE1 1 ATOM 4364 O OE2 . GLU B 1 244 ? 68.376 80.602 93.272 1.00 112.38 ? 310 GLU B OE2 1 ATOM 4365 N N . ALA B 1 245 ? 63.958 78.706 90.243 1.00 45.53 ? 311 ALA B N 1 ATOM 4366 C CA . ALA B 1 245 ? 62.987 77.851 90.928 1.00 44.99 ? 311 ALA B CA 1 ATOM 4367 C C . ALA B 1 245 ? 62.613 76.592 90.119 1.00 49.74 ? 311 ALA B C 1 ATOM 4368 O O . ALA B 1 245 ? 62.276 75.561 90.713 1.00 50.05 ? 311 ALA B O 1 ATOM 4369 C CB . ALA B 1 245 ? 61.738 78.644 91.264 1.00 45.43 ? 311 ALA B CB 1 ATOM 4370 N N . LEU B 1 246 ? 62.689 76.670 88.772 1.00 45.52 ? 312 LEU B N 1 ATOM 4371 C CA . LEU B 1 246 ? 62.397 75.533 87.873 1.00 43.84 ? 312 LEU B CA 1 ATOM 4372 C C . LEU B 1 246 ? 63.642 74.671 87.594 1.00 48.68 ? 312 LEU B C 1 ATOM 4373 O O . LEU B 1 246 ? 63.516 73.528 87.145 1.00 48.28 ? 312 LEU B O 1 ATOM 4374 C CB . LEU B 1 246 ? 61.779 76.012 86.534 1.00 42.70 ? 312 LEU B CB 1 ATOM 4375 C CG . LEU B 1 246 ? 60.491 76.838 86.614 1.00 44.97 ? 312 LEU B CG 1 ATOM 4376 C CD1 . LEU B 1 246 ? 60.205 77.521 85.283 1.00 44.95 ? 312 LEU B CD1 1 ATOM 4377 C CD2 . LEU B 1 246 ? 59.322 75.986 87.068 1.00 43.28 ? 312 LEU B CD2 1 ATOM 4378 N N . GLY B 1 247 ? 64.824 75.222 87.854 1.00 45.50 ? 313 GLY B N 1 ATOM 4379 C CA . GLY B 1 247 ? 66.075 74.528 87.583 1.00 46.00 ? 313 GLY B CA 1 ATOM 4380 C C . GLY B 1 247 ? 66.430 74.577 86.106 1.00 50.43 ? 313 GLY B C 1 ATOM 4381 O O . GLY B 1 247 ? 67.154 73.713 85.607 1.00 51.39 ? 313 GLY B O 1 ATOM 4382 N N . ALA B 1 248 ? 65.909 75.606 85.407 1.00 46.12 ? 314 ALA B N 1 ATOM 4383 C CA . ALA B 1 248 ? 66.134 75.880 83.994 1.00 45.55 ? 314 ALA B CA 1 ATOM 4384 C C . ALA B 1 248 ? 67.409 76.689 83.834 1.00 51.76 ? 314 ALA B C 1 ATOM 4385 O O . ALA B 1 248 ? 67.704 77.570 84.645 1.00 53.15 ? 314 ALA B O 1 ATOM 4386 C CB . ALA B 1 248 ? 64.952 76.635 83.398 1.00 45.49 ? 314 ALA B CB 1 ATOM 4387 N N . LYS B 1 249 ? 68.178 76.393 82.811 1.00 47.62 ? 315 LYS B N 1 ATOM 4388 C CA . LYS B 1 249 ? 69.404 77.148 82.628 1.00 47.03 ? 315 LYS B CA 1 ATOM 4389 C C . LYS B 1 249 ? 69.382 77.855 81.270 1.00 50.30 ? 315 LYS B C 1 ATOM 4390 O O . LYS B 1 249 ? 68.774 77.351 80.330 1.00 48.23 ? 315 LYS B O 1 ATOM 4391 C CB . LYS B 1 249 ? 70.634 76.229 82.825 1.00 48.11 ? 315 LYS B CB 1 ATOM 4392 N N . LYS B 1 250 ? 69.989 79.047 81.193 1.00 48.28 ? 316 LYS B N 1 ATOM 4393 C CA . LYS B 1 250 ? 70.091 79.792 79.945 1.00 48.50 ? 316 LYS B CA 1 ATOM 4394 C C . LYS B 1 250 ? 71.202 79.157 79.114 1.00 56.99 ? 316 LYS B C 1 ATOM 4395 O O . LYS B 1 250 ? 72.380 79.210 79.502 1.00 57.91 ? 316 LYS B O 1 ATOM 4396 C CB . LYS B 1 250 ? 70.389 81.281 80.172 1.00 48.75 ? 316 LYS B CB 1 ATOM 4397 C CG . LYS B 1 250 ? 70.045 82.132 78.961 1.00 55.15 ? 316 LYS B CG 1 ATOM 4398 C CD . LYS B 1 250 ? 69.181 83.303 79.382 1.00 63.47 ? 316 LYS B CD 1 ATOM 4399 C CE . LYS B 1 250 ? 68.627 84.104 78.234 1.00 71.22 ? 316 LYS B CE 1 ATOM 4400 N NZ . LYS B 1 250 ? 67.686 85.162 78.719 1.00 80.44 ? 316 LYS B NZ 1 ATOM 4401 N N . ARG B 1 251 ? 70.804 78.535 77.980 1.00 54.27 ? 317 ARG B N 1 ATOM 4402 C CA . ARG B 1 251 ? 71.635 77.896 76.972 1.00 54.06 ? 317 ARG B CA 1 ATOM 4403 C C . ARG B 1 251 ? 72.531 79.008 76.400 1.00 59.65 ? 317 ARG B C 1 ATOM 4404 O O . ARG B 1 251 ? 73.556 79.379 77.003 1.00 59.61 ? 317 ARG B O 1 ATOM 4405 C CB . ARG B 1 251 ? 70.709 77.313 75.888 1.00 53.05 ? 317 ARG B CB 1 ATOM 4406 C CG . ARG B 1 251 ? 71.096 75.967 75.285 1.00 54.24 ? 317 ARG B CG 1 ATOM 4407 C CD . ARG B 1 251 ? 70.568 75.940 73.871 1.00 55.03 ? 317 ARG B CD 1 ATOM 4408 N NE . ARG B 1 251 ? 69.731 74.785 73.535 1.00 59.58 ? 317 ARG B NE 1 ATOM 4409 C CZ . ARG B 1 251 ? 68.550 74.864 72.922 1.00 74.57 ? 317 ARG B CZ 1 ATOM 4410 N NH1 . ARG B 1 251 ? 68.033 76.047 72.608 1.00 69.78 ? 317 ARG B NH1 1 ATOM 4411 N NH2 . ARG B 1 251 ? 67.873 73.763 72.629 1.00 59.57 ? 317 ARG B NH2 1 ATOM 4412 N N . LEU B 1 252 ? 72.097 79.596 75.298 1.00 56.15 ? 318 LEU B N 1 ATOM 4413 C CA . LEU B 1 252 ? 72.822 80.678 74.666 1.00 55.47 ? 318 LEU B CA 1 ATOM 4414 C C . LEU B 1 252 ? 71.845 81.814 74.528 1.00 56.40 ? 318 LEU B C 1 ATOM 4415 O O . LEU B 1 252 ? 71.992 82.841 75.187 1.00 57.04 ? 318 LEU B O 1 ATOM 4416 C CB . LEU B 1 252 ? 73.387 80.221 73.303 1.00 56.01 ? 318 LEU B CB 1 ATOM 4417 C CG . LEU B 1 252 ? 74.725 79.448 73.352 1.00 61.29 ? 318 LEU B CG 1 ATOM 4418 C CD1 . LEU B 1 252 ? 74.515 77.934 73.574 1.00 62.22 ? 318 LEU B CD1 1 ATOM 4419 C CD2 . LEU B 1 252 ? 75.500 79.656 72.095 1.00 62.15 ? 318 LEU B CD2 1 ATOM 4420 N N . PHE B 1 253 ? 70.785 81.578 73.771 1.00 50.54 ? 319 PHE B N 1 ATOM 4421 C CA . PHE B 1 253 ? 69.739 82.552 73.517 1.00 48.56 ? 319 PHE B CA 1 ATOM 4422 C C . PHE B 1 253 ? 68.571 82.337 74.467 1.00 53.75 ? 319 PHE B C 1 ATOM 4423 O O . PHE B 1 253 ? 67.916 83.318 74.803 1.00 55.17 ? 319 PHE B O 1 ATOM 4424 C CB . PHE B 1 253 ? 69.270 82.471 72.041 1.00 49.06 ? 319 PHE B CB 1 ATOM 4425 C CG . PHE B 1 253 ? 70.370 82.513 70.995 1.00 48.61 ? 319 PHE B CG 1 ATOM 4426 C CD1 . PHE B 1 253 ? 71.008 81.346 70.584 1.00 50.00 ? 319 PHE B CD1 1 ATOM 4427 C CD2 . PHE B 1 253 ? 70.783 83.720 70.443 1.00 49.05 ? 319 PHE B CD2 1 ATOM 4428 C CE1 . PHE B 1 253 ? 72.040 81.384 69.629 1.00 50.28 ? 319 PHE B CE1 1 ATOM 4429 C CE2 . PHE B 1 253 ? 71.823 83.757 69.491 1.00 51.49 ? 319 PHE B CE2 1 ATOM 4430 C CZ . PHE B 1 253 ? 72.431 82.588 69.078 1.00 49.12 ? 319 PHE B CZ 1 ATOM 4431 N N . ASP B 1 254 ? 68.318 81.079 74.932 1.00 49.37 ? 320 ASP B N 1 ATOM 4432 C CA . ASP B 1 254 ? 67.147 80.784 75.780 1.00 48.63 ? 320 ASP B CA 1 ATOM 4433 C C . ASP B 1 254 ? 67.351 79.902 77.011 1.00 50.13 ? 320 ASP B C 1 ATOM 4434 O O . ASP B 1 254 ? 68.352 79.205 77.119 1.00 49.92 ? 320 ASP B O 1 ATOM 4435 C CB . ASP B 1 254 ? 66.051 80.128 74.927 1.00 50.34 ? 320 ASP B CB 1 ATOM 4436 C CG . ASP B 1 254 ? 65.443 81.046 73.905 1.00 62.68 ? 320 ASP B CG 1 ATOM 4437 O OD1 . ASP B 1 254 ? 65.058 82.182 74.283 1.00 64.97 ? 320 ASP B OD1 1 ATOM 4438 O OD2 . ASP B 1 254 ? 65.356 80.640 72.724 1.00 66.41 ? 320 ASP B OD2 1 ATOM 4439 N N . TYR B 1 255 ? 66.320 79.869 77.880 1.00 43.31 ? 321 TYR B N 1 ATOM 4440 C CA . TYR B 1 255 ? 66.222 79.026 79.057 1.00 42.19 ? 321 TYR B CA 1 ATOM 4441 C C . TYR B 1 255 ? 65.764 77.628 78.619 1.00 47.31 ? 321 TYR B C 1 ATOM 4442 O O . TYR B 1 255 ? 64.825 77.513 77.835 1.00 48.11 ? 321 TYR B O 1 ATOM 4443 C CB . TYR B 1 255 ? 65.214 79.617 80.056 1.00 41.91 ? 321 TYR B CB 1 ATOM 4444 C CG . TYR B 1 255 ? 65.754 80.776 80.863 1.00 41.58 ? 321 TYR B CG 1 ATOM 4445 C CD1 . TYR B 1 255 ? 66.661 80.567 81.901 1.00 43.51 ? 321 TYR B CD1 1 ATOM 4446 C CD2 . TYR B 1 255 ? 65.345 82.077 80.606 1.00 41.38 ? 321 TYR B CD2 1 ATOM 4447 C CE1 . TYR B 1 255 ? 67.150 81.632 82.659 1.00 43.96 ? 321 TYR B CE1 1 ATOM 4448 C CE2 . TYR B 1 255 ? 65.829 83.147 81.355 1.00 42.26 ? 321 TYR B CE2 1 ATOM 4449 C CZ . TYR B 1 255 ? 66.723 82.919 82.387 1.00 51.17 ? 321 TYR B CZ 1 ATOM 4450 O OH . TYR B 1 255 ? 67.210 83.980 83.115 1.00 56.85 ? 321 TYR B OH 1 ATOM 4451 N N . VAL B 1 256 ? 66.420 76.573 79.125 1.00 43.56 ? 322 VAL B N 1 ATOM 4452 C CA . VAL B 1 256 ? 66.124 75.176 78.771 1.00 42.83 ? 322 VAL B CA 1 ATOM 4453 C C . VAL B 1 256 ? 66.130 74.252 80.001 1.00 45.78 ? 322 VAL B C 1 ATOM 4454 O O . VAL B 1 256 ? 66.823 74.531 80.980 1.00 45.66 ? 322 VAL B O 1 ATOM 4455 C CB . VAL B 1 256 ? 67.110 74.618 77.676 1.00 45.74 ? 322 VAL B CB 1 ATOM 4456 C CG1 . VAL B 1 256 ? 66.858 75.228 76.302 1.00 44.74 ? 322 VAL B CG1 1 ATOM 4457 C CG2 . VAL B 1 256 ? 68.576 74.785 78.084 1.00 45.57 ? 322 VAL B CG2 1 ATOM 4458 N N . VAL B 1 257 ? 65.413 73.123 79.902 1.00 41.11 ? 323 VAL B N 1 ATOM 4459 C CA . VAL B 1 257 ? 65.415 72.034 80.887 1.00 40.52 ? 323 VAL B CA 1 ATOM 4460 C C . VAL B 1 257 ? 65.724 70.752 80.095 1.00 42.63 ? 323 VAL B C 1 ATOM 4461 O O . VAL B 1 257 ? 65.486 70.731 78.884 1.00 40.15 ? 323 VAL B O 1 ATOM 4462 C CB . VAL B 1 257 ? 64.099 71.882 81.718 1.00 43.53 ? 323 VAL B CB 1 ATOM 4463 C CG1 . VAL B 1 257 ? 63.917 73.031 82.703 1.00 42.97 ? 323 VAL B CG1 1 ATOM 4464 C CG2 . VAL B 1 257 ? 62.882 71.727 80.820 1.00 43.16 ? 323 VAL B CG2 1 ATOM 4465 N N . LYS B 1 258 ? 66.234 69.694 80.762 1.00 40.22 ? 324 LYS B N 1 ATOM 4466 C CA . LYS B 1 258 ? 66.440 68.405 80.089 1.00 40.43 ? 324 LYS B CA 1 ATOM 4467 C C . LYS B 1 258 ? 65.014 67.927 79.796 1.00 44.73 ? 324 LYS B C 1 ATOM 4468 O O . LYS B 1 258 ? 64.185 67.987 80.706 1.00 45.05 ? 324 LYS B O 1 ATOM 4469 C CB . LYS B 1 258 ? 67.154 67.396 81.012 1.00 43.46 ? 324 LYS B CB 1 ATOM 4470 C CG . LYS B 1 258 ? 68.632 67.652 81.250 1.00 59.01 ? 324 LYS B CG 1 ATOM 4471 C CD . LYS B 1 258 ? 69.406 66.321 81.363 1.00 73.89 ? 324 LYS B CD 1 ATOM 4472 C CE . LYS B 1 258 ? 69.509 65.683 82.731 1.00 82.32 ? 324 LYS B CE 1 ATOM 4473 N NZ . LYS B 1 258 ? 70.315 64.438 82.688 1.00 93.40 ? 324 LYS B NZ 1 ATOM 4474 N N . CYS B 1 259 ? 64.711 67.497 78.553 1.00 41.34 ? 325 CYS B N 1 ATOM 4475 C CA . CYS B 1 259 ? 63.353 67.120 78.111 1.00 41.62 ? 325 CYS B CA 1 ATOM 4476 C C . CYS B 1 259 ? 62.621 66.128 79.028 1.00 45.29 ? 325 CYS B C 1 ATOM 4477 O O . CYS B 1 259 ? 61.409 66.266 79.259 1.00 44.34 ? 325 CYS B O 1 ATOM 4478 C CB . CYS B 1 259 ? 63.368 66.630 76.672 1.00 42.38 ? 325 CYS B CB 1 ATOM 4479 S SG . CYS B 1 259 ? 63.829 67.906 75.481 1.00 47.08 ? 325 CYS B SG 1 ATOM 4480 N N . ASN B 1 260 ? 63.353 65.141 79.550 1.00 40.81 ? 326 ASN B N 1 ATOM 4481 C CA . ASN B 1 260 ? 62.789 64.136 80.436 1.00 39.82 ? 326 ASN B CA 1 ATOM 4482 C C . ASN B 1 260 ? 62.351 64.764 81.737 1.00 44.41 ? 326 ASN B C 1 ATOM 4483 O O . ASN B 1 260 ? 61.437 64.255 82.347 1.00 43.49 ? 326 ASN B O 1 ATOM 4484 C CB . ASN B 1 260 ? 63.798 63.019 80.691 1.00 39.14 ? 326 ASN B CB 1 ATOM 4485 C CG . ASN B 1 260 ? 65.049 63.461 81.429 1.00 52.83 ? 326 ASN B CG 1 ATOM 4486 O OD1 . ASN B 1 260 ? 65.816 64.323 80.972 1.00 43.70 ? 326 ASN B OD1 1 ATOM 4487 N ND2 . ASN B 1 260 ? 65.275 62.890 82.597 1.00 39.63 ? 326 ASN B ND2 1 ATOM 4488 N N . GLU B 1 261 ? 62.991 65.855 82.166 1.00 41.90 ? 327 GLU B N 1 ATOM 4489 C CA . GLU B 1 261 ? 62.685 66.528 83.422 1.00 41.86 ? 327 GLU B CA 1 ATOM 4490 C C . GLU B 1 261 ? 61.474 67.447 83.364 1.00 48.02 ? 327 GLU B C 1 ATOM 4491 O O . GLU B 1 261 ? 60.910 67.738 84.411 1.00 47.94 ? 327 GLU B O 1 ATOM 4492 C CB . GLU B 1 261 ? 63.911 67.267 83.946 1.00 42.94 ? 327 GLU B CB 1 ATOM 4493 C CG . GLU B 1 261 ? 64.800 66.335 84.752 1.00 48.20 ? 327 GLU B CG 1 ATOM 4494 C CD . GLU B 1 261 ? 66.222 66.803 84.959 1.00 75.96 ? 327 GLU B CD 1 ATOM 4495 O OE1 . GLU B 1 261 ? 67.122 65.937 84.929 1.00 88.02 ? 327 GLU B OE1 1 ATOM 4496 O OE2 . GLU B 1 261 ? 66.440 68.017 85.180 1.00 69.63 ? 327 GLU B OE2 1 ATOM 4497 N N . GLY B 1 262 ? 61.046 67.840 82.170 1.00 44.74 ? 328 GLY B N 1 ATOM 4498 C CA . GLY B 1 262 ? 59.879 68.694 81.981 1.00 44.27 ? 328 GLY B CA 1 ATOM 4499 C C . GLY B 1 262 ? 58.639 68.249 82.736 1.00 46.48 ? 328 GLY B C 1 ATOM 4500 O O . GLY B 1 262 ? 58.150 69.044 83.542 1.00 46.08 ? 328 GLY B O 1 ATOM 4501 N N . PRO B 1 263 ? 58.148 66.974 82.578 1.00 41.58 ? 329 PRO B N 1 ATOM 4502 C CA . PRO B 1 263 ? 56.953 66.524 83.344 1.00 41.46 ? 329 PRO B CA 1 ATOM 4503 C C . PRO B 1 263 ? 57.059 66.573 84.877 1.00 46.33 ? 329 PRO B C 1 ATOM 4504 O O . PRO B 1 263 ? 56.045 66.392 85.547 1.00 47.19 ? 329 PRO B O 1 ATOM 4505 C CB . PRO B 1 263 ? 56.713 65.082 82.840 1.00 42.82 ? 329 PRO B CB 1 ATOM 4506 C CG . PRO B 1 263 ? 57.411 65.031 81.504 1.00 46.89 ? 329 PRO B CG 1 ATOM 4507 C CD . PRO B 1 263 ? 58.625 65.905 81.676 1.00 42.40 ? 329 PRO B CD 1 ATOM 4508 N N . THR B 1 264 ? 58.264 66.841 85.428 1.00 43.60 ? 330 THR B N 1 ATOM 4509 C CA . THR B 1 264 ? 58.533 66.934 86.875 1.00 43.16 ? 330 THR B CA 1 ATOM 4510 C C . THR B 1 264 ? 58.547 68.363 87.370 1.00 45.99 ? 330 THR B C 1 ATOM 4511 O O . THR B 1 264 ? 58.687 68.584 88.572 1.00 46.69 ? 330 THR B O 1 ATOM 4512 C CB . THR B 1 264 ? 59.866 66.242 87.255 1.00 52.13 ? 330 THR B CB 1 ATOM 4513 O OG1 . THR B 1 264 ? 60.996 67.022 86.856 1.00 47.96 ? 330 THR B OG1 1 ATOM 4514 C CG2 . THR B 1 264 ? 59.973 64.868 86.715 1.00 51.77 ? 330 THR B CG2 1 ATOM 4515 N N . LEU B 1 265 ? 58.472 69.339 86.453 1.00 41.52 ? 331 LEU B N 1 ATOM 4516 C CA . LEU B 1 265 ? 58.490 70.757 86.818 1.00 40.47 ? 331 LEU B CA 1 ATOM 4517 C C . LEU B 1 265 ? 57.178 71.171 87.506 1.00 44.12 ? 331 LEU B C 1 ATOM 4518 O O . LEU B 1 265 ? 56.120 70.614 87.189 1.00 43.10 ? 331 LEU B O 1 ATOM 4519 C CB . LEU B 1 265 ? 58.801 71.638 85.609 1.00 40.02 ? 331 LEU B CB 1 ATOM 4520 C CG . LEU B 1 265 ? 60.193 71.534 85.001 1.00 43.35 ? 331 LEU B CG 1 ATOM 4521 C CD1 . LEU B 1 265 ? 60.576 72.845 84.359 1.00 42.96 ? 331 LEU B CD1 1 ATOM 4522 C CD2 . LEU B 1 265 ? 61.247 71.200 86.040 1.00 44.41 ? 331 LEU B CD2 1 ATOM 4523 N N . PRO B 1 266 ? 57.226 72.103 88.487 1.00 41.39 ? 332 PRO B N 1 ATOM 4524 C CA . PRO B 1 266 ? 55.992 72.455 89.204 1.00 41.12 ? 332 PRO B CA 1 ATOM 4525 C C . PRO B 1 266 ? 55.001 73.276 88.382 1.00 45.94 ? 332 PRO B C 1 ATOM 4526 O O . PRO B 1 266 ? 55.346 73.791 87.317 1.00 44.66 ? 332 PRO B O 1 ATOM 4527 C CB . PRO B 1 266 ? 56.504 73.237 90.423 1.00 42.18 ? 332 PRO B CB 1 ATOM 4528 C CG . PRO B 1 266 ? 57.774 73.873 89.947 1.00 46.42 ? 332 PRO B CG 1 ATOM 4529 C CD . PRO B 1 266 ? 58.388 72.865 89.011 1.00 42.51 ? 332 PRO B CD 1 ATOM 4530 N N . ASP B 1 267 ? 53.765 73.410 88.908 1.00 41.94 ? 333 ASP B N 1 ATOM 4531 C CA . ASP B 1 267 ? 52.713 74.210 88.303 1.00 39.82 ? 333 ASP B CA 1 ATOM 4532 C C . ASP B 1 267 ? 53.051 75.673 88.523 1.00 41.35 ? 333 ASP B C 1 ATOM 4533 O O . ASP B 1 267 ? 53.654 76.015 89.538 1.00 41.61 ? 333 ASP B O 1 ATOM 4534 C CB . ASP B 1 267 ? 51.370 73.915 88.983 1.00 40.79 ? 333 ASP B CB 1 ATOM 4535 C CG . ASP B 1 267 ? 50.748 72.551 88.735 1.00 47.06 ? 333 ASP B CG 1 ATOM 4536 O OD1 . ASP B 1 267 ? 51.306 71.773 87.920 1.00 47.95 ? 333 ASP B OD1 1 ATOM 4537 O OD2 . ASP B 1 267 ? 49.660 72.283 89.307 1.00 49.39 ? 333 ASP B OD2 1 ATOM 4538 N N . ILE B 1 268 ? 52.688 76.532 87.563 1.00 35.56 ? 334 ILE B N 1 ATOM 4539 C CA . ILE B 1 268 ? 52.862 77.974 87.696 1.00 34.86 ? 334 ILE B CA 1 ATOM 4540 C C . ILE B 1 268 ? 51.463 78.552 87.730 1.00 38.53 ? 334 ILE B C 1 ATOM 4541 O O . ILE B 1 268 ? 50.640 78.212 86.881 1.00 36.46 ? 334 ILE B O 1 ATOM 4542 C CB . ILE B 1 268 ? 53.821 78.655 86.682 1.00 37.07 ? 334 ILE B CB 1 ATOM 4543 C CG1 . ILE B 1 268 ? 55.197 77.946 86.709 1.00 35.95 ? 334 ILE B CG1 1 ATOM 4544 C CG2 . ILE B 1 268 ? 53.982 80.168 87.010 1.00 37.07 ? 334 ILE B CG2 1 ATOM 4545 C CD1 . ILE B 1 268 ? 56.105 78.285 85.637 1.00 34.64 ? 334 ILE B CD1 1 ATOM 4546 N N . SER B 1 269 ? 51.178 79.365 88.762 1.00 35.93 ? 335 SER B N 1 ATOM 4547 C CA . SER B 1 269 ? 49.866 79.940 88.989 1.00 35.77 ? 335 SER B CA 1 ATOM 4548 C C . SER B 1 269 ? 49.919 81.436 88.992 1.00 36.92 ? 335 SER B C 1 ATOM 4549 O O . SER B 1 269 ? 50.802 82.019 89.602 1.00 36.58 ? 335 SER B O 1 ATOM 4550 C CB . SER B 1 269 ? 49.282 79.413 90.297 1.00 40.56 ? 335 SER B CB 1 ATOM 4551 O OG . SER B 1 269 ? 49.073 78.008 90.229 1.00 52.24 ? 335 SER B OG 1 ATOM 4552 N N . PHE B 1 270 ? 48.975 82.052 88.291 1.00 33.07 ? 336 PHE B N 1 ATOM 4553 C CA . PHE B 1 270 ? 48.854 83.504 88.146 1.00 32.63 ? 336 PHE B CA 1 ATOM 4554 C C . PHE B 1 270 ? 47.556 83.920 88.841 1.00 39.65 ? 336 PHE B C 1 ATOM 4555 O O . PHE B 1 270 ? 46.475 83.447 88.461 1.00 38.59 ? 336 PHE B O 1 ATOM 4556 C CB . PHE B 1 270 ? 48.868 83.923 86.650 1.00 32.73 ? 336 PHE B CB 1 ATOM 4557 C CG . PHE B 1 270 ? 50.054 83.401 85.869 1.00 32.90 ? 336 PHE B CG 1 ATOM 4558 C CD1 . PHE B 1 270 ? 50.008 82.151 85.258 1.00 35.15 ? 336 PHE B CD1 1 ATOM 4559 C CD2 . PHE B 1 270 ? 51.220 84.164 85.734 1.00 32.79 ? 336 PHE B CD2 1 ATOM 4560 C CE1 . PHE B 1 270 ? 51.125 81.642 84.574 1.00 34.47 ? 336 PHE B CE1 1 ATOM 4561 C CE2 . PHE B 1 270 ? 52.330 83.656 85.044 1.00 34.39 ? 336 PHE B CE2 1 ATOM 4562 C CZ . PHE B 1 270 ? 52.270 82.397 84.470 1.00 32.20 ? 336 PHE B CZ 1 ATOM 4563 N N . HIS B 1 271 ? 47.676 84.738 89.896 1.00 39.89 ? 337 HIS B N 1 ATOM 4564 C CA . HIS B 1 271 ? 46.531 85.201 90.669 1.00 42.21 ? 337 HIS B CA 1 ATOM 4565 C C . HIS B 1 271 ? 45.944 86.460 90.017 1.00 42.21 ? 337 HIS B C 1 ATOM 4566 O O . HIS B 1 271 ? 46.573 87.521 90.018 1.00 42.56 ? 337 HIS B O 1 ATOM 4567 C CB . HIS B 1 271 ? 46.921 85.444 92.141 1.00 45.77 ? 337 HIS B CB 1 ATOM 4568 C CG . HIS B 1 271 ? 45.740 85.535 93.075 1.00 52.07 ? 337 HIS B CG 1 ATOM 4569 N ND1 . HIS B 1 271 ? 45.753 84.919 94.316 1.00 55.38 ? 337 HIS B ND1 1 ATOM 4570 C CD2 . HIS B 1 271 ? 44.549 86.174 92.925 1.00 55.76 ? 337 HIS B CD2 1 ATOM 4571 C CE1 . HIS B 1 271 ? 44.576 85.192 94.871 1.00 55.54 ? 337 HIS B CE1 1 ATOM 4572 N NE2 . HIS B 1 271 ? 43.821 85.946 94.071 1.00 55.88 ? 337 HIS B NE2 1 ATOM 4573 N N . LEU B 1 272 ? 44.721 86.336 89.486 1.00 35.44 ? 338 LEU B N 1 ATOM 4574 C CA . LEU B 1 272 ? 44.018 87.407 88.774 1.00 33.71 ? 338 LEU B CA 1 ATOM 4575 C C . LEU B 1 272 ? 42.532 87.381 89.215 1.00 37.48 ? 338 LEU B C 1 ATOM 4576 O O . LEU B 1 272 ? 41.876 86.349 89.082 1.00 36.67 ? 338 LEU B O 1 ATOM 4577 C CB . LEU B 1 272 ? 44.145 87.223 87.222 1.00 32.68 ? 338 LEU B CB 1 ATOM 4578 C CG . LEU B 1 272 ? 45.536 86.884 86.597 1.00 36.59 ? 338 LEU B CG 1 ATOM 4579 C CD1 . LEU B 1 272 ? 45.390 86.068 85.309 1.00 36.52 ? 338 LEU B CD1 1 ATOM 4580 C CD2 . LEU B 1 272 ? 46.342 88.118 86.304 1.00 37.98 ? 338 LEU B CD2 1 ATOM 4581 N N . GLY B 1 273 ? 42.046 88.487 89.783 1.00 34.43 ? 339 GLY B N 1 ATOM 4582 C CA . GLY B 1 273 ? 40.671 88.599 90.278 1.00 34.37 ? 339 GLY B CA 1 ATOM 4583 C C . GLY B 1 273 ? 40.248 87.595 91.341 1.00 38.85 ? 339 GLY B C 1 ATOM 4584 O O . GLY B 1 273 ? 39.135 87.048 91.291 1.00 37.29 ? 339 GLY B O 1 ATOM 4585 N N . GLY B 1 274 ? 41.137 87.314 92.289 1.00 38.16 ? 340 GLY B N 1 ATOM 4586 C CA . GLY B 1 274 ? 40.809 86.401 93.388 1.00 40.11 ? 340 GLY B CA 1 ATOM 4587 C C . GLY B 1 274 ? 40.856 84.925 93.054 1.00 49.22 ? 340 GLY B C 1 ATOM 4588 O O . GLY B 1 274 ? 40.908 84.099 93.973 1.00 49.72 ? 340 GLY B O 1 ATOM 4589 N N . LYS B 1 275 ? 40.817 84.589 91.722 1.00 46.94 ? 341 LYS B N 1 ATOM 4590 C CA . LYS B 1 275 ? 40.925 83.252 91.125 1.00 45.12 ? 341 LYS B CA 1 ATOM 4591 C C . LYS B 1 275 ? 42.413 82.993 90.767 1.00 48.16 ? 341 LYS B C 1 ATOM 4592 O O . LYS B 1 275 ? 43.182 83.938 90.594 1.00 49.26 ? 341 LYS B O 1 ATOM 4593 C CB . LYS B 1 275 ? 40.026 83.146 89.888 1.00 46.03 ? 341 LYS B CB 1 ATOM 4594 N N . GLU B 1 276 ? 42.826 81.728 90.723 1.00 43.06 ? 342 GLU B N 1 ATOM 4595 C CA . GLU B 1 276 ? 44.199 81.320 90.405 1.00 41.41 ? 342 GLU B CA 1 ATOM 4596 C C . GLU B 1 276 ? 44.178 80.597 89.064 1.00 41.55 ? 342 GLU B C 1 ATOM 4597 O O . GLU B 1 276 ? 43.353 79.711 88.856 1.00 41.62 ? 342 GLU B O 1 ATOM 4598 C CB . GLU B 1 276 ? 44.787 80.421 91.513 1.00 42.79 ? 342 GLU B CB 1 ATOM 4599 C CG . GLU B 1 276 ? 45.342 81.183 92.722 1.00 54.96 ? 342 GLU B CG 1 ATOM 4600 C CD . GLU B 1 276 ? 46.707 81.847 92.598 1.00 84.41 ? 342 GLU B CD 1 ATOM 4601 O OE1 . GLU B 1 276 ? 47.396 81.624 91.578 1.00 94.14 ? 342 GLU B OE1 1 ATOM 4602 O OE2 . GLU B 1 276 ? 47.102 82.577 93.535 1.00 76.69 ? 342 GLU B OE2 1 ATOM 4603 N N . TYR B 1 277 ? 45.025 81.047 88.126 1.00 35.03 ? 343 TYR B N 1 ATOM 4604 C CA . TYR B 1 277 ? 45.151 80.527 86.750 1.00 32.53 ? 343 TYR B CA 1 ATOM 4605 C C . TYR B 1 277 ? 46.419 79.724 86.663 1.00 35.17 ? 343 TYR B C 1 ATOM 4606 O O . TYR B 1 277 ? 47.515 80.283 86.661 1.00 34.60 ? 343 TYR B O 1 ATOM 4607 C CB . TYR B 1 277 ? 45.074 81.688 85.714 1.00 31.40 ? 343 TYR B CB 1 ATOM 4608 C CG . TYR B 1 277 ? 43.684 82.282 85.682 1.00 30.16 ? 343 TYR B CG 1 ATOM 4609 C CD1 . TYR B 1 277 ? 42.672 81.684 84.938 1.00 30.88 ? 343 TYR B CD1 1 ATOM 4610 C CD2 . TYR B 1 277 ? 43.335 83.343 86.524 1.00 30.02 ? 343 TYR B CD2 1 ATOM 4611 C CE1 . TYR B 1 277 ? 41.361 82.135 85.009 1.00 30.50 ? 343 TYR B CE1 1 ATOM 4612 C CE2 . TYR B 1 277 ? 42.030 83.838 86.562 1.00 29.13 ? 343 TYR B CE2 1 ATOM 4613 C CZ . TYR B 1 277 ? 41.043 83.214 85.818 1.00 37.50 ? 343 TYR B CZ 1 ATOM 4614 O OH . TYR B 1 277 ? 39.749 83.637 85.865 1.00 38.47 ? 343 TYR B OH 1 ATOM 4615 N N . THR B 1 278 ? 46.257 78.398 86.664 1.00 32.78 ? 344 THR B N 1 ATOM 4616 C CA . THR B 1 278 ? 47.337 77.433 86.743 1.00 33.38 ? 344 THR B CA 1 ATOM 4617 C C . THR B 1 278 ? 47.690 76.751 85.421 1.00 38.21 ? 344 THR B C 1 ATOM 4618 O O . THR B 1 278 ? 46.845 76.172 84.729 1.00 38.49 ? 344 THR B O 1 ATOM 4619 C CB . THR B 1 278 ? 47.023 76.411 87.859 1.00 36.73 ? 344 THR B CB 1 ATOM 4620 O OG1 . THR B 1 278 ? 46.802 77.134 89.080 1.00 37.53 ? 344 THR B OG1 1 ATOM 4621 C CG2 . THR B 1 278 ? 48.147 75.398 88.071 1.00 28.46 ? 344 THR B CG2 1 ATOM 4622 N N . LEU B 1 279 ? 48.988 76.756 85.144 1.00 35.12 ? 345 LEU B N 1 ATOM 4623 C CA . LEU B 1 279 ? 49.608 76.105 84.009 1.00 36.12 ? 345 LEU B CA 1 ATOM 4624 C C . LEU B 1 279 ? 50.510 75.000 84.553 1.00 39.02 ? 345 LEU B C 1 ATOM 4625 O O . LEU B 1 279 ? 51.326 75.262 85.437 1.00 38.40 ? 345 LEU B O 1 ATOM 4626 C CB . LEU B 1 279 ? 50.455 77.137 83.233 1.00 36.61 ? 345 LEU B CB 1 ATOM 4627 C CG . LEU B 1 279 ? 49.771 78.007 82.167 1.00 41.07 ? 345 LEU B CG 1 ATOM 4628 C CD1 . LEU B 1 279 ? 48.773 79.027 82.704 1.00 41.31 ? 345 LEU B CD1 1 ATOM 4629 C CD2 . LEU B 1 279 ? 50.783 78.556 81.225 1.00 42.96 ? 345 LEU B CD2 1 ATOM 4630 N N . THR B 1 280 ? 50.357 73.771 84.039 1.00 35.34 ? 346 THR B N 1 ATOM 4631 C CA . THR B 1 280 ? 51.213 72.638 84.408 1.00 35.05 ? 346 THR B CA 1 ATOM 4632 C C . THR B 1 280 ? 52.438 72.679 83.489 1.00 39.87 ? 346 THR B C 1 ATOM 4633 O O . THR B 1 280 ? 52.463 73.475 82.547 1.00 39.93 ? 346 THR B O 1 ATOM 4634 C CB . THR B 1 280 ? 50.454 71.292 84.334 1.00 38.24 ? 346 THR B CB 1 ATOM 4635 O OG1 . THR B 1 280 ? 50.226 70.925 82.982 1.00 37.27 ? 346 THR B OG1 1 ATOM 4636 C CG2 . THR B 1 280 ? 49.140 71.296 85.120 1.00 34.20 ? 346 THR B CG2 1 ATOM 4637 N N . SER B 1 281 ? 53.450 71.835 83.746 1.00 37.64 ? 347 SER B N 1 ATOM 4638 C CA . SER B 1 281 ? 54.670 71.782 82.911 1.00 36.97 ? 347 SER B CA 1 ATOM 4639 C C . SER B 1 281 ? 54.338 71.473 81.442 1.00 40.22 ? 347 SER B C 1 ATOM 4640 O O . SER B 1 281 ? 54.955 72.042 80.548 1.00 41.42 ? 347 SER B O 1 ATOM 4641 C CB . SER B 1 281 ? 55.666 70.782 83.473 1.00 39.10 ? 347 SER B CB 1 ATOM 4642 O OG . SER B 1 281 ? 55.050 69.514 83.612 1.00 48.19 ? 347 SER B OG 1 ATOM 4643 N N . ALA B 1 282 ? 53.297 70.666 81.203 1.00 35.89 ? 348 ALA B N 1 ATOM 4644 C CA . ALA B 1 282 ? 52.824 70.319 79.858 1.00 35.83 ? 348 ALA B CA 1 ATOM 4645 C C . ALA B 1 282 ? 52.336 71.562 79.105 1.00 41.12 ? 348 ALA B C 1 ATOM 4646 O O . ALA B 1 282 ? 52.391 71.588 77.877 1.00 42.70 ? 348 ALA B O 1 ATOM 4647 C CB . ALA B 1 282 ? 51.703 69.288 79.953 1.00 35.86 ? 348 ALA B CB 1 ATOM 4648 N N . ASP B 1 283 ? 51.895 72.600 79.848 1.00 36.75 ? 349 ASP B N 1 ATOM 4649 C CA . ASP B 1 283 ? 51.388 73.858 79.298 1.00 35.64 ? 349 ASP B CA 1 ATOM 4650 C C . ASP B 1 283 ? 52.459 74.873 78.973 1.00 37.52 ? 349 ASP B C 1 ATOM 4651 O O . ASP B 1 283 ? 52.218 75.725 78.117 1.00 36.70 ? 349 ASP B O 1 ATOM 4652 C CB . ASP B 1 283 ? 50.365 74.488 80.244 1.00 37.26 ? 349 ASP B CB 1 ATOM 4653 C CG . ASP B 1 283 ? 49.142 73.634 80.547 1.00 37.85 ? 349 ASP B CG 1 ATOM 4654 O OD1 . ASP B 1 283 ? 48.569 73.051 79.597 1.00 36.57 ? 349 ASP B OD1 1 ATOM 4655 O OD2 . ASP B 1 283 ? 48.716 73.606 81.714 1.00 42.52 ? 349 ASP B OD2 1 ATOM 4656 N N . TYR B 1 284 ? 53.628 74.816 79.647 1.00 33.85 ? 350 TYR B N 1 ATOM 4657 C CA . TYR B 1 284 ? 54.678 75.811 79.393 1.00 33.84 ? 350 TYR B CA 1 ATOM 4658 C C . TYR B 1 284 ? 56.007 75.211 78.880 1.00 39.68 ? 350 TYR B C 1 ATOM 4659 O O . TYR B 1 284 ? 56.921 75.966 78.547 1.00 40.60 ? 350 TYR B O 1 ATOM 4660 C CB . TYR B 1 284 ? 54.902 76.725 80.609 1.00 33.69 ? 350 TYR B CB 1 ATOM 4661 C CG . TYR B 1 284 ? 55.447 76.043 81.851 1.00 35.61 ? 350 TYR B CG 1 ATOM 4662 C CD1 . TYR B 1 284 ? 56.817 75.840 82.017 1.00 37.28 ? 350 TYR B CD1 1 ATOM 4663 C CD2 . TYR B 1 284 ? 54.614 75.723 82.915 1.00 35.92 ? 350 TYR B CD2 1 ATOM 4664 C CE1 . TYR B 1 284 ? 57.330 75.250 83.172 1.00 36.66 ? 350 TYR B CE1 1 ATOM 4665 C CE2 . TYR B 1 284 ? 55.113 75.127 84.074 1.00 37.01 ? 350 TYR B CE2 1 ATOM 4666 C CZ . TYR B 1 284 ? 56.476 74.898 84.203 1.00 44.99 ? 350 TYR B CZ 1 ATOM 4667 O OH . TYR B 1 284 ? 56.988 74.330 85.355 1.00 44.06 ? 350 TYR B OH 1 ATOM 4668 N N . VAL B 1 285 ? 56.112 73.882 78.779 1.00 36.32 ? 351 VAL B N 1 ATOM 4669 C CA . VAL B 1 285 ? 57.340 73.261 78.251 1.00 36.24 ? 351 VAL B CA 1 ATOM 4670 C C . VAL B 1 285 ? 57.090 72.799 76.835 1.00 38.63 ? 351 VAL B C 1 ATOM 4671 O O . VAL B 1 285 ? 56.114 72.089 76.596 1.00 37.13 ? 351 VAL B O 1 ATOM 4672 C CB . VAL B 1 285 ? 57.906 72.102 79.136 1.00 40.02 ? 351 VAL B CB 1 ATOM 4673 C CG1 . VAL B 1 285 ? 59.191 71.540 78.539 1.00 39.93 ? 351 VAL B CG1 1 ATOM 4674 C CG2 . VAL B 1 285 ? 58.146 72.550 80.580 1.00 39.39 ? 351 VAL B CG2 1 ATOM 4675 N N . PHE B 1 286 ? 57.967 73.189 75.894 1.00 36.30 ? 352 PHE B N 1 ATOM 4676 C CA . PHE B 1 286 ? 57.850 72.711 74.522 1.00 36.51 ? 352 PHE B CA 1 ATOM 4677 C C . PHE B 1 286 ? 58.489 71.334 74.491 1.00 42.91 ? 352 PHE B C 1 ATOM 4678 O O . PHE B 1 286 ? 59.692 71.213 74.247 1.00 42.39 ? 352 PHE B O 1 ATOM 4679 C CB . PHE B 1 286 ? 58.520 73.671 73.528 1.00 38.18 ? 352 PHE B CB 1 ATOM 4680 C CG . PHE B 1 286 ? 57.775 74.957 73.267 1.00 39.96 ? 352 PHE B CG 1 ATOM 4681 C CD1 . PHE B 1 286 ? 56.527 74.950 72.636 1.00 43.19 ? 352 PHE B CD1 1 ATOM 4682 C CD2 . PHE B 1 286 ? 58.337 76.173 73.600 1.00 42.24 ? 352 PHE B CD2 1 ATOM 4683 C CE1 . PHE B 1 286 ? 55.868 76.145 72.328 1.00 44.07 ? 352 PHE B CE1 1 ATOM 4684 C CE2 . PHE B 1 286 ? 57.688 77.367 73.280 1.00 45.45 ? 352 PHE B CE2 1 ATOM 4685 C CZ . PHE B 1 286 ? 56.442 77.347 72.664 1.00 43.71 ? 352 PHE B CZ 1 ATOM 4686 N N . GLN B 1 287 ? 57.697 70.294 74.798 1.00 41.71 ? 353 GLN B N 1 ATOM 4687 C CA . GLN B 1 287 ? 58.191 68.918 74.864 1.00 41.96 ? 353 GLN B CA 1 ATOM 4688 C C . GLN B 1 287 ? 58.371 68.337 73.468 1.00 50.47 ? 353 GLN B C 1 ATOM 4689 O O . GLN B 1 287 ? 57.626 67.426 73.070 1.00 50.65 ? 353 GLN B O 1 ATOM 4690 C CB . GLN B 1 287 ? 57.297 68.031 75.735 1.00 42.35 ? 353 GLN B CB 1 ATOM 4691 C CG . GLN B 1 287 ? 57.127 68.502 77.181 1.00 49.02 ? 353 GLN B CG 1 ATOM 4692 C CD . GLN B 1 287 ? 58.251 68.157 78.149 1.00 58.23 ? 353 GLN B CD 1 ATOM 4693 O OE1 . GLN B 1 287 ? 58.159 68.438 79.344 1.00 50.15 ? 353 GLN B OE1 1 ATOM 4694 N NE2 . GLN B 1 287 ? 59.338 67.564 77.684 1.00 44.76 ? 353 GLN B NE2 1 ATOM 4695 N N . GLU B 1 288 ? 59.386 68.870 72.726 1.00 49.19 ? 354 GLU B N 1 ATOM 4696 C CA . GLU B 1 288 ? 59.780 68.443 71.379 1.00 50.07 ? 354 GLU B CA 1 ATOM 4697 C C . GLU B 1 288 ? 60.189 66.975 71.385 1.00 55.42 ? 354 GLU B C 1 ATOM 4698 O O . GLU B 1 288 ? 60.119 66.333 70.344 1.00 55.67 ? 354 GLU B O 1 ATOM 4699 C CB . GLU B 1 288 ? 60.886 69.348 70.803 1.00 51.73 ? 354 GLU B CB 1 ATOM 4700 N N . SER B 1 289 ? 60.550 66.439 72.590 1.00 53.23 ? 355 SER B N 1 ATOM 4701 C CA . SER B 1 289 ? 60.894 65.051 72.921 1.00 53.07 ? 355 SER B CA 1 ATOM 4702 C C . SER B 1 289 ? 60.810 64.897 74.438 1.00 56.17 ? 355 SER B C 1 ATOM 4703 O O . SER B 1 289 ? 60.510 65.869 75.122 1.00 55.84 ? 355 SER B O 1 ATOM 4704 C CB . SER B 1 289 ? 62.283 64.690 72.387 1.00 56.60 ? 355 SER B CB 1 ATOM 4705 O OG . SER B 1 289 ? 63.324 64.950 73.310 1.00 65.57 ? 355 SER B OG 1 ATOM 4706 N N . TYR B 1 290 ? 61.065 63.700 74.972 1.00 52.61 ? 356 TYR B N 1 ATOM 4707 C CA . TYR B 1 290 ? 61.074 63.452 76.425 1.00 52.24 ? 356 TYR B CA 1 ATOM 4708 C C . TYR B 1 290 ? 62.371 62.713 76.781 1.00 53.86 ? 356 TYR B C 1 ATOM 4709 O O . TYR B 1 290 ? 62.460 62.013 77.798 1.00 53.17 ? 356 TYR B O 1 ATOM 4710 C CB . TYR B 1 290 ? 59.814 62.695 76.879 1.00 54.24 ? 356 TYR B CB 1 ATOM 4711 C CG . TYR B 1 290 ? 58.531 63.487 76.707 1.00 58.12 ? 356 TYR B CG 1 ATOM 4712 C CD1 . TYR B 1 290 ? 57.872 63.529 75.479 1.00 60.11 ? 356 TYR B CD1 1 ATOM 4713 C CD2 . TYR B 1 290 ? 57.948 64.155 77.785 1.00 58.89 ? 356 TYR B CD2 1 ATOM 4714 C CE1 . TYR B 1 290 ? 56.702 64.265 75.311 1.00 61.13 ? 356 TYR B CE1 1 ATOM 4715 C CE2 . TYR B 1 290 ? 56.757 64.869 77.635 1.00 59.87 ? 356 TYR B CE2 1 ATOM 4716 C CZ . TYR B 1 290 ? 56.131 64.913 76.396 1.00 68.14 ? 356 TYR B CZ 1 ATOM 4717 O OH . TYR B 1 290 ? 54.963 65.630 76.210 1.00 68.54 ? 356 TYR B OH 1 ATOM 4718 N N . SER B 1 291 ? 63.389 62.920 75.920 1.00 49.03 ? 357 SER B N 1 ATOM 4719 C CA . SER B 1 291 ? 64.729 62.341 75.991 1.00 48.21 ? 357 SER B CA 1 ATOM 4720 C C . SER B 1 291 ? 65.586 62.980 77.073 1.00 49.80 ? 357 SER B C 1 ATOM 4721 O O . SER B 1 291 ? 65.638 64.212 77.183 1.00 47.43 ? 357 SER B O 1 ATOM 4722 C CB . SER B 1 291 ? 65.437 62.475 74.643 1.00 52.30 ? 357 SER B CB 1 ATOM 4723 O OG . SER B 1 291 ? 66.758 61.968 74.697 1.00 64.85 ? 357 SER B OG 1 ATOM 4724 N N . SER B 1 292 ? 66.306 62.121 77.829 1.00 46.33 ? 358 SER B N 1 ATOM 4725 C CA . SER B 1 292 ? 67.288 62.504 78.846 1.00 46.32 ? 358 SER B CA 1 ATOM 4726 C C . SER B 1 292 ? 68.563 63.071 78.177 1.00 50.03 ? 358 SER B C 1 ATOM 4727 O O . SER B 1 292 ? 69.364 63.742 78.844 1.00 50.23 ? 358 SER B O 1 ATOM 4728 C CB . SER B 1 292 ? 67.629 61.315 79.742 1.00 49.83 ? 358 SER B CB 1 ATOM 4729 O OG . SER B 1 292 ? 67.773 60.102 79.016 1.00 58.54 ? 358 SER B OG 1 ATOM 4730 N N . LYS B 1 293 ? 68.694 62.836 76.851 1.00 45.92 ? 359 LYS B N 1 ATOM 4731 C CA . LYS B 1 293 ? 69.788 63.231 75.954 1.00 46.00 ? 359 LYS B CA 1 ATOM 4732 C C . LYS B 1 293 ? 69.492 64.535 75.188 1.00 49.63 ? 359 LYS B C 1 ATOM 4733 O O . LYS B 1 293 ? 70.294 64.932 74.347 1.00 49.63 ? 359 LYS B O 1 ATOM 4734 C CB . LYS B 1 293 ? 70.067 62.085 74.935 1.00 48.34 ? 359 LYS B CB 1 ATOM 4735 C CG . LYS B 1 293 ? 70.145 60.667 75.531 1.00 53.98 ? 359 LYS B CG 1 ATOM 4736 C CD . LYS B 1 293 ? 69.314 59.685 74.715 1.00 62.01 ? 359 LYS B CD 1 ATOM 4737 C CE . LYS B 1 293 ? 69.512 58.225 75.083 1.00 58.04 ? 359 LYS B CE 1 ATOM 4738 N NZ . LYS B 1 293 ? 68.779 57.838 76.308 1.00 48.62 ? 359 LYS B NZ 1 ATOM 4739 N N . LYS B 1 294 ? 68.354 65.192 75.471 1.00 46.58 ? 360 LYS B N 1 ATOM 4740 C CA . LYS B 1 294 ? 67.940 66.404 74.762 1.00 46.35 ? 360 LYS B CA 1 ATOM 4741 C C . LYS B 1 294 ? 67.462 67.530 75.681 1.00 48.32 ? 360 LYS B C 1 ATOM 4742 O O . LYS B 1 294 ? 66.987 67.270 76.781 1.00 46.26 ? 360 LYS B O 1 ATOM 4743 C CB . LYS B 1 294 ? 66.886 66.061 73.700 1.00 48.50 ? 360 LYS B CB 1 ATOM 4744 C CG . LYS B 1 294 ? 67.514 65.695 72.365 1.00 66.41 ? 360 LYS B CG 1 ATOM 4745 C CD . LYS B 1 294 ? 66.761 64.590 71.670 1.00 80.78 ? 360 LYS B CD 1 ATOM 4746 C CE . LYS B 1 294 ? 67.133 64.504 70.210 1.00 92.91 ? 360 LYS B CE 1 ATOM 4747 N NZ . LYS B 1 294 ? 66.313 65.428 69.381 1.00 103.87 ? 360 LYS B NZ 1 ATOM 4748 N N . LEU B 1 295 ? 67.619 68.786 75.223 1.00 45.67 ? 361 LEU B N 1 ATOM 4749 C CA . LEU B 1 295 ? 67.205 69.994 75.948 1.00 45.24 ? 361 LEU B CA 1 ATOM 4750 C C . LEU B 1 295 ? 65.937 70.572 75.350 1.00 49.21 ? 361 LEU B C 1 ATOM 4751 O O . LEU B 1 295 ? 65.817 70.644 74.123 1.00 49.94 ? 361 LEU B O 1 ATOM 4752 C CB . LEU B 1 295 ? 68.306 71.053 75.937 1.00 45.00 ? 361 LEU B CB 1 ATOM 4753 C CG . LEU B 1 295 ? 69.629 70.697 76.614 1.00 48.20 ? 361 LEU B CG 1 ATOM 4754 C CD1 . LEU B 1 295 ? 70.663 71.793 76.373 1.00 47.96 ? 361 LEU B CD1 1 ATOM 4755 C CD2 . LEU B 1 295 ? 69.440 70.486 78.083 1.00 47.63 ? 361 LEU B CD2 1 ATOM 4756 N N . CYS B 1 296 ? 64.985 70.963 76.217 1.00 44.34 ? 362 CYS B N 1 ATOM 4757 C CA . CYS B 1 296 ? 63.675 71.485 75.837 1.00 42.90 ? 362 CYS B CA 1 ATOM 4758 C C . CYS B 1 296 ? 63.468 72.919 76.270 1.00 46.04 ? 362 CYS B C 1 ATOM 4759 O O . CYS B 1 296 ? 63.767 73.262 77.415 1.00 45.77 ? 362 CYS B O 1 ATOM 4760 C CB . CYS B 1 296 ? 62.578 70.574 76.370 1.00 43.14 ? 362 CYS B CB 1 ATOM 4761 S SG . CYS B 1 296 ? 62.222 69.154 75.305 1.00 47.24 ? 362 CYS B SG 1 ATOM 4762 N N . THR B 1 297 ? 62.973 73.769 75.338 1.00 42.17 ? 363 THR B N 1 ATOM 4763 C CA . THR B 1 297 ? 62.683 75.190 75.579 1.00 40.87 ? 363 THR B CA 1 ATOM 4764 C C . THR B 1 297 ? 61.371 75.410 76.331 1.00 43.04 ? 363 THR B C 1 ATOM 4765 O O . THR B 1 297 ? 60.469 74.562 76.308 1.00 41.12 ? 363 THR B O 1 ATOM 4766 C CB . THR B 1 297 ? 62.726 75.994 74.299 1.00 45.18 ? 363 THR B CB 1 ATOM 4767 O OG1 . THR B 1 297 ? 62.035 75.278 73.302 1.00 47.91 ? 363 THR B OG1 1 ATOM 4768 C CG2 . THR B 1 297 ? 64.153 76.267 73.851 1.00 43.67 ? 363 THR B CG2 1 ATOM 4769 N N . LEU B 1 298 ? 61.283 76.553 77.012 1.00 40.09 ? 364 LEU B N 1 ATOM 4770 C CA . LEU B 1 298 ? 60.118 76.950 77.792 1.00 39.86 ? 364 LEU B CA 1 ATOM 4771 C C . LEU B 1 298 ? 59.367 78.069 77.064 1.00 43.33 ? 364 LEU B C 1 ATOM 4772 O O . LEU B 1 298 ? 59.969 78.928 76.426 1.00 43.44 ? 364 LEU B O 1 ATOM 4773 C CB . LEU B 1 298 ? 60.516 77.354 79.224 1.00 40.21 ? 364 LEU B CB 1 ATOM 4774 C CG . LEU B 1 298 ? 61.381 76.368 80.068 1.00 46.36 ? 364 LEU B CG 1 ATOM 4775 C CD1 . LEU B 1 298 ? 61.362 76.756 81.514 1.00 46.91 ? 364 LEU B CD1 1 ATOM 4776 C CD2 . LEU B 1 298 ? 60.829 74.969 80.070 1.00 52.21 ? 364 LEU B CD2 1 ATOM 4777 N N . ALA B 1 299 ? 58.039 77.987 77.077 1.00 38.97 ? 365 ALA B N 1 ATOM 4778 C CA . ALA B 1 299 ? 57.103 78.932 76.461 1.00 37.15 ? 365 ALA B CA 1 ATOM 4779 C C . ALA B 1 299 ? 56.867 80.170 77.361 1.00 40.44 ? 365 ALA B C 1 ATOM 4780 O O . ALA B 1 299 ? 55.792 80.788 77.320 1.00 40.40 ? 365 ALA B O 1 ATOM 4781 C CB . ALA B 1 299 ? 55.791 78.221 76.168 1.00 37.25 ? 365 ALA B CB 1 ATOM 4782 N N . ILE B 1 300 ? 57.880 80.497 78.186 1.00 36.34 ? 366 ILE B N 1 ATOM 4783 C CA . ILE B 1 300 ? 57.984 81.662 79.065 1.00 37.61 ? 366 ILE B CA 1 ATOM 4784 C C . ILE B 1 300 ? 59.356 82.307 78.785 1.00 42.09 ? 366 ILE B C 1 ATOM 4785 O O . ILE B 1 300 ? 60.386 81.641 78.869 1.00 41.71 ? 366 ILE B O 1 ATOM 4786 C CB . ILE B 1 300 ? 57.755 81.331 80.590 1.00 41.58 ? 366 ILE B CB 1 ATOM 4787 C CG1 . ILE B 1 300 ? 56.365 80.684 80.836 1.00 40.87 ? 366 ILE B CG1 1 ATOM 4788 C CG2 . ILE B 1 300 ? 57.951 82.591 81.488 1.00 42.85 ? 366 ILE B CG2 1 ATOM 4789 C CD1 . ILE B 1 300 ? 56.214 79.988 82.162 1.00 36.78 ? 366 ILE B CD1 1 ATOM 4790 N N . HIS B 1 301 ? 59.358 83.579 78.400 1.00 41.59 ? 367 HIS B N 1 ATOM 4791 C CA . HIS B 1 301 ? 60.571 84.327 78.056 1.00 43.81 ? 367 HIS B CA 1 ATOM 4792 C C . HIS B 1 301 ? 60.597 85.663 78.791 1.00 49.93 ? 367 HIS B C 1 ATOM 4793 O O . HIS B 1 301 ? 59.541 86.179 79.137 1.00 50.39 ? 367 HIS B O 1 ATOM 4794 C CB . HIS B 1 301 ? 60.630 84.590 76.526 1.00 45.35 ? 367 HIS B CB 1 ATOM 4795 C CG . HIS B 1 301 ? 60.939 83.373 75.692 1.00 50.16 ? 367 HIS B CG 1 ATOM 4796 N ND1 . HIS B 1 301 ? 61.982 83.370 74.766 1.00 52.77 ? 367 HIS B ND1 1 ATOM 4797 C CD2 . HIS B 1 301 ? 60.317 82.168 75.642 1.00 52.46 ? 367 HIS B CD2 1 ATOM 4798 C CE1 . HIS B 1 301 ? 61.958 82.172 74.202 1.00 52.02 ? 367 HIS B CE1 1 ATOM 4799 N NE2 . HIS B 1 301 ? 60.972 81.415 74.694 1.00 52.41 ? 367 HIS B NE2 1 ATOM 4800 N N . ALA B 1 302 ? 61.789 86.240 79.013 1.00 46.65 ? 368 ALA B N 1 ATOM 4801 C CA . ALA B 1 302 ? 61.896 87.567 79.611 1.00 46.24 ? 368 ALA B CA 1 ATOM 4802 C C . ALA B 1 302 ? 61.655 88.601 78.528 1.00 51.70 ? 368 ALA B C 1 ATOM 4803 O O . ALA B 1 302 ? 62.023 88.406 77.368 1.00 52.16 ? 368 ALA B O 1 ATOM 4804 C CB . ALA B 1 302 ? 63.267 87.769 80.222 1.00 46.52 ? 368 ALA B CB 1 ATOM 4805 N N . MET B 1 303 ? 60.968 89.659 78.899 1.00 49.43 ? 369 MET B N 1 ATOM 4806 C CA . MET B 1 303 ? 60.695 90.799 78.046 1.00 50.29 ? 369 MET B CA 1 ATOM 4807 C C . MET B 1 303 ? 60.525 92.014 78.936 1.00 53.05 ? 369 MET B C 1 ATOM 4808 O O . MET B 1 303 ? 59.667 92.023 79.814 1.00 52.71 ? 369 MET B O 1 ATOM 4809 C CB . MET B 1 303 ? 59.488 90.571 77.119 1.00 53.33 ? 369 MET B CB 1 ATOM 4810 C CG . MET B 1 303 ? 59.053 91.831 76.389 1.00 58.77 ? 369 MET B CG 1 ATOM 4811 S SD . MET B 1 303 ? 59.034 91.776 74.588 1.00 64.61 ? 369 MET B SD 1 ATOM 4812 C CE . MET B 1 303 ? 60.792 91.697 74.247 1.00 61.33 ? 369 MET B CE 1 ATOM 4813 N N . ASP B 1 304 ? 61.367 93.021 78.729 1.00 49.89 ? 370 ASP B N 1 ATOM 4814 C CA . ASP B 1 304 ? 61.282 94.254 79.504 1.00 50.29 ? 370 ASP B CA 1 ATOM 4815 C C . ASP B 1 304 ? 60.488 95.260 78.698 1.00 55.11 ? 370 ASP B C 1 ATOM 4816 O O . ASP B 1 304 ? 60.981 95.805 77.708 1.00 54.90 ? 370 ASP B O 1 ATOM 4817 C CB . ASP B 1 304 ? 62.678 94.789 79.904 1.00 51.86 ? 370 ASP B CB 1 ATOM 4818 C CG . ASP B 1 304 ? 63.509 93.815 80.721 1.00 57.14 ? 370 ASP B CG 1 ATOM 4819 O OD1 . ASP B 1 304 ? 63.002 93.318 81.754 1.00 57.25 ? 370 ASP B OD1 1 ATOM 4820 O OD2 . ASP B 1 304 ? 64.672 93.569 80.341 1.00 61.16 ? 370 ASP B OD2 1 ATOM 4821 N N . ILE B 1 305 ? 59.216 95.425 79.064 1.00 52.23 ? 371 ILE B N 1 ATOM 4822 C CA . ILE B 1 305 ? 58.325 96.338 78.357 1.00 52.04 ? 371 ILE B CA 1 ATOM 4823 C C . ILE B 1 305 ? 58.520 97.740 78.935 1.00 59.57 ? 371 ILE B C 1 ATOM 4824 O O . ILE B 1 305 ? 58.477 97.894 80.155 1.00 59.05 ? 371 ILE B O 1 ATOM 4825 C CB . ILE B 1 305 ? 56.858 95.823 78.309 1.00 53.93 ? 371 ILE B CB 1 ATOM 4826 C CG1 . ILE B 1 305 ? 56.792 94.526 77.469 1.00 52.11 ? 371 ILE B CG1 1 ATOM 4827 C CG2 . ILE B 1 305 ? 55.890 96.897 77.741 1.00 55.32 ? 371 ILE B CG2 1 ATOM 4828 C CD1 . ILE B 1 305 ? 55.820 93.578 77.917 1.00 50.27 ? 371 ILE B CD1 1 ATOM 4829 N N . PRO B 1 306 ? 58.847 98.748 78.087 1.00 58.89 ? 372 PRO B N 1 ATOM 4830 C CA . PRO B 1 306 ? 59.113 100.090 78.621 1.00 59.12 ? 372 PRO B CA 1 ATOM 4831 C C . PRO B 1 306 ? 57.846 100.854 79.026 1.00 65.06 ? 372 PRO B C 1 ATOM 4832 O O . PRO B 1 306 ? 56.755 100.522 78.534 1.00 65.36 ? 372 PRO B O 1 ATOM 4833 C CB . PRO B 1 306 ? 59.847 100.781 77.468 1.00 60.55 ? 372 PRO B CB 1 ATOM 4834 C CG . PRO B 1 306 ? 59.312 100.150 76.257 1.00 65.11 ? 372 PRO B CG 1 ATOM 4835 C CD . PRO B 1 306 ? 59.016 98.717 76.616 1.00 60.80 ? 372 PRO B CD 1 ATOM 4836 N N . PRO B 1 307 ? 57.966 101.917 79.873 1.00 61.04 ? 373 PRO B N 1 ATOM 4837 C CA . PRO B 1 307 ? 56.774 102.708 80.223 1.00 59.64 ? 373 PRO B CA 1 ATOM 4838 C C . PRO B 1 307 ? 56.153 103.414 79.003 1.00 59.50 ? 373 PRO B C 1 ATOM 4839 O O . PRO B 1 307 ? 56.812 103.508 77.964 1.00 58.09 ? 373 PRO B O 1 ATOM 4840 C CB . PRO B 1 307 ? 57.302 103.694 81.279 1.00 61.99 ? 373 PRO B CB 1 ATOM 4841 C CG . PRO B 1 307 ? 58.604 103.106 81.766 1.00 66.74 ? 373 PRO B CG 1 ATOM 4842 C CD . PRO B 1 307 ? 59.171 102.448 80.549 1.00 62.50 ? 373 PRO B CD 1 ATOM 4843 N N . PRO B 1 308 ? 54.875 103.856 79.046 1.00 54.58 ? 374 PRO B N 1 ATOM 4844 C CA . PRO B 1 308 ? 53.932 103.812 80.183 1.00 54.24 ? 374 PRO B CA 1 ATOM 4845 C C . PRO B 1 308 ? 53.295 102.439 80.447 1.00 57.09 ? 374 PRO B C 1 ATOM 4846 O O . PRO B 1 308 ? 52.889 102.187 81.587 1.00 57.45 ? 374 PRO B O 1 ATOM 4847 C CB . PRO B 1 308 ? 52.906 104.896 79.819 1.00 56.02 ? 374 PRO B CB 1 ATOM 4848 C CG . PRO B 1 308 ? 52.876 104.889 78.305 1.00 60.03 ? 374 PRO B CG 1 ATOM 4849 C CD . PRO B 1 308 ? 54.278 104.516 77.863 1.00 55.29 ? 374 PRO B CD 1 ATOM 4850 N N . THR B 1 309 ? 53.222 101.554 79.414 1.00 52.15 ? 375 THR B N 1 ATOM 4851 C CA . THR B 1 309 ? 52.620 100.212 79.504 1.00 51.93 ? 375 THR B CA 1 ATOM 4852 C C . THR B 1 309 ? 53.379 99.301 80.503 1.00 54.38 ? 375 THR B C 1 ATOM 4853 O O . THR B 1 309 ? 52.755 98.670 81.368 1.00 53.31 ? 375 THR B O 1 ATOM 4854 C CB . THR B 1 309 ? 52.468 99.605 78.101 1.00 60.53 ? 375 THR B CB 1 ATOM 4855 O OG1 . THR B 1 309 ? 51.652 100.473 77.301 1.00 57.97 ? 375 THR B OG1 1 ATOM 4856 C CG2 . THR B 1 309 ? 51.847 98.230 78.131 1.00 59.25 ? 375 THR B CG2 1 ATOM 4857 N N . GLY B 1 310 ? 54.702 99.264 80.371 1.00 50.68 ? 376 GLY B N 1 ATOM 4858 C CA . GLY B 1 310 ? 55.561 98.486 81.250 1.00 50.63 ? 376 GLY B CA 1 ATOM 4859 C C . GLY B 1 310 ? 56.161 99.307 82.386 1.00 55.43 ? 376 GLY B C 1 ATOM 4860 O O . GLY B 1 310 ? 55.964 100.525 82.430 1.00 55.88 ? 376 GLY B O 1 ATOM 4861 N N . PRO B 1 311 ? 56.919 98.696 83.333 1.00 51.09 ? 377 PRO B N 1 ATOM 4862 C CA . PRO B 1 311 ? 57.227 97.259 83.470 1.00 49.93 ? 377 PRO B CA 1 ATOM 4863 C C . PRO B 1 311 ? 55.949 96.469 83.715 1.00 51.88 ? 377 PRO B C 1 ATOM 4864 O O . PRO B 1 311 ? 55.073 96.902 84.480 1.00 52.49 ? 377 PRO B O 1 ATOM 4865 C CB . PRO B 1 311 ? 58.181 97.208 84.678 1.00 51.65 ? 377 PRO B CB 1 ATOM 4866 C CG . PRO B 1 311 ? 58.686 98.620 84.839 1.00 56.72 ? 377 PRO B CG 1 ATOM 4867 C CD . PRO B 1 311 ? 57.522 99.466 84.435 1.00 52.63 ? 377 PRO B CD 1 ATOM 4868 N N . THR B 1 312 ? 55.815 95.337 83.010 1.00 45.52 ? 378 THR B N 1 ATOM 4869 C CA . THR B 1 312 ? 54.633 94.483 83.085 1.00 42.97 ? 378 THR B CA 1 ATOM 4870 C C . THR B 1 312 ? 54.919 93.045 82.660 1.00 45.23 ? 378 THR B C 1 ATOM 4871 O O . THR B 1 312 ? 55.840 92.778 81.871 1.00 44.42 ? 378 THR B O 1 ATOM 4872 C CB . THR B 1 312 ? 53.499 95.085 82.213 1.00 39.10 ? 378 THR B CB 1 ATOM 4873 O OG1 . THR B 1 312 ? 52.312 94.351 82.423 1.00 39.35 ? 378 THR B OG1 1 ATOM 4874 C CG2 . THR B 1 312 ? 53.828 95.128 80.716 1.00 35.44 ? 378 THR B CG2 1 ATOM 4875 N N . TRP B 1 313 ? 54.083 92.117 83.159 1.00 38.37 ? 379 TRP B N 1 ATOM 4876 C CA . TRP B 1 313 ? 54.100 90.775 82.642 1.00 36.35 ? 379 TRP B CA 1 ATOM 4877 C C . TRP B 1 313 ? 53.196 90.837 81.379 1.00 39.18 ? 379 TRP B C 1 ATOM 4878 O O . TRP B 1 313 ? 52.341 91.732 81.245 1.00 37.37 ? 379 TRP B O 1 ATOM 4879 C CB . TRP B 1 313 ? 53.491 89.791 83.627 1.00 34.28 ? 379 TRP B CB 1 ATOM 4880 C CG . TRP B 1 313 ? 54.336 89.508 84.826 1.00 34.70 ? 379 TRP B CG 1 ATOM 4881 C CD1 . TRP B 1 313 ? 54.519 90.320 85.913 1.00 37.51 ? 379 TRP B CD1 1 ATOM 4882 C CD2 . TRP B 1 313 ? 54.989 88.267 85.135 1.00 34.06 ? 379 TRP B CD2 1 ATOM 4883 N NE1 . TRP B 1 313 ? 55.289 89.679 86.860 1.00 35.93 ? 379 TRP B NE1 1 ATOM 4884 C CE2 . TRP B 1 313 ? 55.584 88.413 86.413 1.00 37.34 ? 379 TRP B CE2 1 ATOM 4885 C CE3 . TRP B 1 313 ? 55.141 87.042 84.450 1.00 35.09 ? 379 TRP B CE3 1 ATOM 4886 C CZ2 . TRP B 1 313 ? 56.320 87.382 87.022 1.00 36.37 ? 379 TRP B CZ2 1 ATOM 4887 C CZ3 . TRP B 1 313 ? 55.876 86.023 85.052 1.00 36.42 ? 379 TRP B CZ3 1 ATOM 4888 C CH2 . TRP B 1 313 ? 56.451 86.195 86.324 1.00 36.91 ? 379 TRP B CH2 1 ATOM 4889 N N . ALA B 1 314 ? 53.389 89.911 80.454 1.00 36.07 ? 380 ALA B N 1 ATOM 4890 C CA . ALA B 1 314 ? 52.507 89.842 79.294 1.00 36.10 ? 380 ALA B CA 1 ATOM 4891 C C . ALA B 1 314 ? 52.034 88.416 79.194 1.00 39.51 ? 380 ALA B C 1 ATOM 4892 O O . ALA B 1 314 ? 52.846 87.486 79.279 1.00 40.33 ? 380 ALA B O 1 ATOM 4893 C CB . ALA B 1 314 ? 53.205 90.290 78.014 1.00 36.73 ? 380 ALA B CB 1 ATOM 4894 N N . LEU B 1 315 ? 50.717 88.235 79.124 1.00 34.10 ? 381 LEU B N 1 ATOM 4895 C CA . LEU B 1 315 ? 50.111 86.919 79.018 1.00 33.05 ? 381 LEU B CA 1 ATOM 4896 C C . LEU B 1 315 ? 49.751 86.732 77.550 1.00 34.00 ? 381 LEU B C 1 ATOM 4897 O O . LEU B 1 315 ? 48.740 87.252 77.077 1.00 31.10 ? 381 LEU B O 1 ATOM 4898 C CB . LEU B 1 315 ? 48.901 86.767 79.970 1.00 33.08 ? 381 LEU B CB 1 ATOM 4899 C CG . LEU B 1 315 ? 49.158 86.970 81.475 1.00 36.27 ? 381 LEU B CG 1 ATOM 4900 C CD1 . LEU B 1 315 ? 47.831 87.030 82.257 1.00 35.02 ? 381 LEU B CD1 1 ATOM 4901 C CD2 . LEU B 1 315 ? 50.096 85.894 82.045 1.00 37.58 ? 381 LEU B CD2 1 ATOM 4902 N N . GLY B 1 316 ? 50.678 86.097 76.825 1.00 31.86 ? 382 GLY B N 1 ATOM 4903 C CA . GLY B 1 316 ? 50.584 85.849 75.394 1.00 31.45 ? 382 GLY B CA 1 ATOM 4904 C C . GLY B 1 316 ? 49.977 84.510 75.078 1.00 36.54 ? 382 GLY B C 1 ATOM 4905 O O . GLY B 1 316 ? 49.267 83.947 75.912 1.00 37.05 ? 382 GLY B O 1 ATOM 4906 N N . ALA B 1 317 ? 50.283 83.971 73.882 1.00 33.37 ? 383 ALA B N 1 ATOM 4907 C CA . ALA B 1 317 ? 49.736 82.705 73.395 1.00 32.48 ? 383 ALA B CA 1 ATOM 4908 C C . ALA B 1 317 ? 49.861 81.545 74.374 1.00 34.95 ? 383 ALA B C 1 ATOM 4909 O O . ALA B 1 317 ? 48.924 80.754 74.465 1.00 34.26 ? 383 ALA B O 1 ATOM 4910 C CB . ALA B 1 317 ? 50.332 82.346 72.040 1.00 33.22 ? 383 ALA B CB 1 ATOM 4911 N N . THR B 1 318 ? 50.960 81.459 75.145 1.00 32.25 ? 384 THR B N 1 ATOM 4912 C CA . THR B 1 318 ? 51.098 80.386 76.148 1.00 31.92 ? 384 THR B CA 1 ATOM 4913 C C . THR B 1 318 ? 49.896 80.401 77.100 1.00 34.44 ? 384 THR B C 1 ATOM 4914 O O . THR B 1 318 ? 49.287 79.364 77.317 1.00 33.45 ? 384 THR B O 1 ATOM 4915 C CB . THR B 1 318 ? 52.408 80.517 76.921 1.00 37.66 ? 384 THR B CB 1 ATOM 4916 O OG1 . THR B 1 318 ? 53.447 80.652 75.980 1.00 32.71 ? 384 THR B OG1 1 ATOM 4917 C CG2 . THR B 1 318 ? 52.680 79.313 77.843 1.00 37.35 ? 384 THR B CG2 1 ATOM 4918 N N . PHE B 1 319 ? 49.528 81.587 77.609 1.00 30.35 ? 385 PHE B N 1 ATOM 4919 C CA . PHE B 1 319 ? 48.402 81.721 78.530 1.00 29.96 ? 385 PHE B CA 1 ATOM 4920 C C . PHE B 1 319 ? 47.050 81.468 77.868 1.00 32.73 ? 385 PHE B C 1 ATOM 4921 O O . PHE B 1 319 ? 46.279 80.683 78.395 1.00 33.46 ? 385 PHE B O 1 ATOM 4922 C CB . PHE B 1 319 ? 48.437 83.077 79.246 1.00 30.46 ? 385 PHE B CB 1 ATOM 4923 C CG . PHE B 1 319 ? 47.493 83.154 80.430 1.00 31.22 ? 385 PHE B CG 1 ATOM 4924 C CD1 . PHE B 1 319 ? 47.883 82.698 81.690 1.00 32.71 ? 385 PHE B CD1 1 ATOM 4925 C CD2 . PHE B 1 319 ? 46.211 83.683 80.286 1.00 31.89 ? 385 PHE B CD2 1 ATOM 4926 C CE1 . PHE B 1 319 ? 47.006 82.789 82.791 1.00 33.16 ? 385 PHE B CE1 1 ATOM 4927 C CE2 . PHE B 1 319 ? 45.340 83.757 81.385 1.00 33.31 ? 385 PHE B CE2 1 ATOM 4928 C CZ . PHE B 1 319 ? 45.749 83.328 82.626 1.00 31.58 ? 385 PHE B CZ 1 ATOM 4929 N N . ILE B 1 320 ? 46.781 82.116 76.715 1.00 28.84 ? 386 ILE B N 1 ATOM 4930 C CA . ILE B 1 320 ? 45.538 82.000 75.937 1.00 28.65 ? 386 ILE B CA 1 ATOM 4931 C C . ILE B 1 320 ? 45.246 80.541 75.496 1.00 32.48 ? 386 ILE B C 1 ATOM 4932 O O . ILE B 1 320 ? 44.080 80.159 75.439 1.00 32.01 ? 386 ILE B O 1 ATOM 4933 C CB . ILE B 1 320 ? 45.527 83.012 74.763 1.00 31.35 ? 386 ILE B CB 1 ATOM 4934 C CG1 . ILE B 1 320 ? 45.628 84.456 75.314 1.00 31.28 ? 386 ILE B CG1 1 ATOM 4935 C CG2 . ILE B 1 320 ? 44.272 82.844 73.889 1.00 32.04 ? 386 ILE B CG2 1 ATOM 4936 C CD1 . ILE B 1 320 ? 46.299 85.469 74.392 1.00 41.41 ? 386 ILE B CD1 1 ATOM 4937 N N . ARG B 1 321 ? 46.279 79.725 75.228 1.00 29.36 ? 387 ARG B N 1 ATOM 4938 C CA . ARG B 1 321 ? 46.068 78.331 74.847 1.00 29.32 ? 387 ARG B CA 1 ATOM 4939 C C . ARG B 1 321 ? 45.316 77.575 75.950 1.00 34.41 ? 387 ARG B C 1 ATOM 4940 O O . ARG B 1 321 ? 44.409 76.788 75.663 1.00 34.63 ? 387 ARG B O 1 ATOM 4941 C CB . ARG B 1 321 ? 47.401 77.628 74.557 1.00 27.65 ? 387 ARG B CB 1 ATOM 4942 C CG . ARG B 1 321 ? 47.851 77.747 73.126 1.00 22.49 ? 387 ARG B CG 1 ATOM 4943 C CD . ARG B 1 321 ? 48.997 76.782 72.802 1.00 22.26 ? 387 ARG B CD 1 ATOM 4944 N NE . ARG B 1 321 ? 50.273 77.082 73.471 1.00 22.27 ? 387 ARG B NE 1 ATOM 4945 C CZ . ARG B 1 321 ? 51.154 77.988 73.066 1.00 30.95 ? 387 ARG B CZ 1 ATOM 4946 N NH1 . ARG B 1 321 ? 50.896 78.752 72.013 1.00 31.79 ? 387 ARG B NH1 1 ATOM 4947 N NH2 . ARG B 1 321 ? 52.288 78.160 73.731 1.00 21.79 ? 387 ARG B NH2 1 ATOM 4948 N N . LYS B 1 322 ? 45.675 77.848 77.215 1.00 29.83 ? 388 LYS B N 1 ATOM 4949 C CA . LYS B 1 322 ? 45.063 77.223 78.378 1.00 29.21 ? 388 LYS B CA 1 ATOM 4950 C C . LYS B 1 322 ? 43.703 77.863 78.709 1.00 32.99 ? 388 LYS B C 1 ATOM 4951 O O . LYS B 1 322 ? 42.753 77.159 79.042 1.00 35.30 ? 388 LYS B O 1 ATOM 4952 C CB . LYS B 1 322 ? 46.041 77.306 79.578 1.00 29.79 ? 388 LYS B CB 1 ATOM 4953 C CG . LYS B 1 322 ? 45.528 76.644 80.863 1.00 26.54 ? 388 LYS B CG 1 ATOM 4954 C CD . LYS B 1 322 ? 45.724 75.145 80.938 1.00 37.11 ? 388 LYS B CD 1 ATOM 4955 C CE . LYS B 1 322 ? 45.279 74.591 82.258 1.00 45.43 ? 388 LYS B CE 1 ATOM 4956 N NZ . LYS B 1 322 ? 45.864 73.261 82.471 1.00 54.88 ? 388 LYS B NZ 1 ATOM 4957 N N . PHE B 1 323 ? 43.614 79.185 78.581 1.00 27.20 ? 389 PHE B N 1 ATOM 4958 C CA . PHE B 1 323 ? 42.421 79.945 78.911 1.00 26.46 ? 389 PHE B CA 1 ATOM 4959 C C . PHE B 1 323 ? 41.827 80.725 77.759 1.00 29.96 ? 389 PHE B C 1 ATOM 4960 O O . PHE B 1 323 ? 42.385 81.732 77.320 1.00 30.66 ? 389 PHE B O 1 ATOM 4961 C CB . PHE B 1 323 ? 42.706 80.884 80.111 1.00 27.74 ? 389 PHE B CB 1 ATOM 4962 C CG . PHE B 1 323 ? 43.157 80.115 81.325 1.00 28.64 ? 389 PHE B CG 1 ATOM 4963 C CD1 . PHE B 1 323 ? 42.263 79.315 82.033 1.00 28.75 ? 389 PHE B CD1 1 ATOM 4964 C CD2 . PHE B 1 323 ? 44.489 80.135 81.723 1.00 29.38 ? 389 PHE B CD2 1 ATOM 4965 C CE1 . PHE B 1 323 ? 42.682 78.556 83.109 1.00 28.91 ? 389 PHE B CE1 1 ATOM 4966 C CE2 . PHE B 1 323 ? 44.901 79.398 82.825 1.00 31.24 ? 389 PHE B CE2 1 ATOM 4967 C CZ . PHE B 1 323 ? 43.994 78.596 83.498 1.00 29.05 ? 389 PHE B CZ 1 ATOM 4968 N N . TYR B 1 324 ? 40.657 80.284 77.314 1.00 27.07 ? 390 TYR B N 1 ATOM 4969 C CA . TYR B 1 324 ? 39.845 80.958 76.318 1.00 26.84 ? 390 TYR B CA 1 ATOM 4970 C C . TYR B 1 324 ? 39.626 82.386 76.882 1.00 30.20 ? 390 TYR B C 1 ATOM 4971 O O . TYR B 1 324 ? 39.347 82.529 78.074 1.00 28.49 ? 390 TYR B O 1 ATOM 4972 C CB . TYR B 1 324 ? 38.505 80.215 76.160 1.00 26.80 ? 390 TYR B CB 1 ATOM 4973 C CG . TYR B 1 324 ? 37.672 80.750 75.019 1.00 28.84 ? 390 TYR B CG 1 ATOM 4974 C CD1 . TYR B 1 324 ? 36.800 81.822 75.205 1.00 30.99 ? 390 TYR B CD1 1 ATOM 4975 C CD2 . TYR B 1 324 ? 37.777 80.206 73.742 1.00 28.73 ? 390 TYR B CD2 1 ATOM 4976 C CE1 . TYR B 1 324 ? 36.042 82.328 74.152 1.00 31.18 ? 390 TYR B CE1 1 ATOM 4977 C CE2 . TYR B 1 324 ? 37.009 80.691 72.688 1.00 29.50 ? 390 TYR B CE2 1 ATOM 4978 C CZ . TYR B 1 324 ? 36.165 81.770 72.889 1.00 34.26 ? 390 TYR B CZ 1 ATOM 4979 O OH . TYR B 1 324 ? 35.458 82.268 71.821 1.00 28.91 ? 390 TYR B OH 1 ATOM 4980 N N . THR B 1 325 ? 39.842 83.420 76.057 1.00 27.53 ? 391 THR B N 1 ATOM 4981 C CA . THR B 1 325 ? 39.803 84.814 76.495 1.00 27.09 ? 391 THR B CA 1 ATOM 4982 C C . THR B 1 325 ? 38.756 85.660 75.785 1.00 31.43 ? 391 THR B C 1 ATOM 4983 O O . THR B 1 325 ? 38.677 85.675 74.557 1.00 29.76 ? 391 THR B O 1 ATOM 4984 C CB . THR B 1 325 ? 41.217 85.432 76.368 1.00 33.52 ? 391 THR B CB 1 ATOM 4985 O OG1 . THR B 1 325 ? 42.149 84.586 77.035 1.00 31.80 ? 391 THR B OG1 1 ATOM 4986 C CG2 . THR B 1 325 ? 41.303 86.829 76.938 1.00 28.39 ? 391 THR B CG2 1 ATOM 4987 N N . GLU B 1 326 ? 37.981 86.405 76.588 1.00 29.54 ? 392 GLU B N 1 ATOM 4988 C CA . GLU B 1 326 ? 36.971 87.328 76.114 1.00 29.22 ? 392 GLU B CA 1 ATOM 4989 C C . GLU B 1 326 ? 37.379 88.736 76.510 1.00 34.36 ? 392 GLU B C 1 ATOM 4990 O O . GLU B 1 326 ? 37.604 89.013 77.687 1.00 36.21 ? 392 GLU B O 1 ATOM 4991 C CB . GLU B 1 326 ? 35.579 86.958 76.644 1.00 29.95 ? 392 GLU B CB 1 ATOM 4992 C CG . GLU B 1 326 ? 34.519 87.980 76.275 1.00 36.68 ? 392 GLU B CG 1 ATOM 4993 C CD . GLU B 1 326 ? 33.146 87.659 76.809 1.00 46.65 ? 392 GLU B CD 1 ATOM 4994 O OE1 . GLU B 1 326 ? 32.504 86.725 76.276 1.00 45.51 ? 392 GLU B OE1 1 ATOM 4995 O OE2 . GLU B 1 326 ? 32.751 88.276 77.823 1.00 40.71 ? 392 GLU B OE2 1 ATOM 4996 N N . PHE B 1 327 ? 37.484 89.623 75.523 1.00 29.91 ? 393 PHE B N 1 ATOM 4997 C CA . PHE B 1 327 ? 37.848 91.021 75.744 1.00 28.88 ? 393 PHE B CA 1 ATOM 4998 C C . PHE B 1 327 ? 36.570 91.812 75.702 1.00 32.94 ? 393 PHE B C 1 ATOM 4999 O O . PHE B 1 327 ? 35.950 91.907 74.656 1.00 32.55 ? 393 PHE B O 1 ATOM 5000 C CB . PHE B 1 327 ? 38.863 91.487 74.681 1.00 29.31 ? 393 PHE B CB 1 ATOM 5001 C CG . PHE B 1 327 ? 40.172 90.737 74.751 1.00 28.80 ? 393 PHE B CG 1 ATOM 5002 C CD1 . PHE B 1 327 ? 41.205 91.183 75.577 1.00 29.67 ? 393 PHE B CD1 1 ATOM 5003 C CD2 . PHE B 1 327 ? 40.373 89.579 74.001 1.00 29.82 ? 393 PHE B CD2 1 ATOM 5004 C CE1 . PHE B 1 327 ? 42.413 90.483 75.657 1.00 29.37 ? 393 PHE B CE1 1 ATOM 5005 C CE2 . PHE B 1 327 ? 41.583 88.878 74.081 1.00 32.62 ? 393 PHE B CE2 1 ATOM 5006 C CZ . PHE B 1 327 ? 42.593 89.336 74.911 1.00 30.47 ? 393 PHE B CZ 1 ATOM 5007 N N . ASP B 1 328 ? 36.136 92.313 76.874 1.00 31.74 ? 394 ASP B N 1 ATOM 5008 C CA . ASP B 1 328 ? 34.863 93.019 77.056 1.00 30.87 ? 394 ASP B CA 1 ATOM 5009 C C . ASP B 1 328 ? 35.046 94.536 77.076 1.00 35.46 ? 394 ASP B C 1 ATOM 5010 O O . ASP B 1 328 ? 35.490 95.103 78.077 1.00 35.78 ? 394 ASP B O 1 ATOM 5011 C CB . ASP B 1 328 ? 34.180 92.498 78.330 1.00 32.09 ? 394 ASP B CB 1 ATOM 5012 C CG . ASP B 1 328 ? 32.763 92.962 78.598 1.00 34.00 ? 394 ASP B CG 1 ATOM 5013 O OD1 . ASP B 1 328 ? 32.313 93.908 77.929 1.00 32.38 ? 394 ASP B OD1 1 ATOM 5014 O OD2 . ASP B 1 328 ? 32.111 92.385 79.505 1.00 30.20 ? 394 ASP B OD2 1 ATOM 5015 N N . ARG B 1 329 ? 34.677 95.191 75.970 1.00 32.53 ? 395 ARG B N 1 ATOM 5016 C CA . ARG B 1 329 ? 34.791 96.642 75.823 1.00 33.06 ? 395 ARG B CA 1 ATOM 5017 C C . ARG B 1 329 ? 33.724 97.413 76.607 1.00 39.28 ? 395 ARG B C 1 ATOM 5018 O O . ARG B 1 329 ? 34.031 98.440 77.213 1.00 40.96 ? 395 ARG B O 1 ATOM 5019 C CB . ARG B 1 329 ? 34.760 97.042 74.338 1.00 32.63 ? 395 ARG B CB 1 ATOM 5020 C CG . ARG B 1 329 ? 36.039 96.725 73.555 1.00 38.99 ? 395 ARG B CG 1 ATOM 5021 C CD . ARG B 1 329 ? 37.108 97.779 73.789 1.00 54.59 ? 395 ARG B CD 1 ATOM 5022 N NE . ARG B 1 329 ? 36.624 99.133 73.524 1.00 75.38 ? 395 ARG B NE 1 ATOM 5023 C CZ . ARG B 1 329 ? 36.734 99.756 72.356 1.00 88.63 ? 395 ARG B CZ 1 ATOM 5024 N NH1 . ARG B 1 329 ? 37.353 99.170 71.339 1.00 69.40 ? 395 ARG B NH1 1 ATOM 5025 N NH2 . ARG B 1 329 ? 36.250 100.981 72.205 1.00 79.93 ? 395 ARG B NH2 1 ATOM 5026 N N . ARG B 1 330 ? 32.492 96.918 76.608 1.00 36.78 ? 396 ARG B N 1 ATOM 5027 C CA . ARG B 1 330 ? 31.385 97.546 77.328 1.00 38.12 ? 396 ARG B CA 1 ATOM 5028 C C . ARG B 1 330 ? 31.717 97.742 78.823 1.00 41.96 ? 396 ARG B C 1 ATOM 5029 O O . ARG B 1 330 ? 31.500 98.833 79.370 1.00 42.68 ? 396 ARG B O 1 ATOM 5030 C CB . ARG B 1 330 ? 30.082 96.717 77.126 1.00 38.18 ? 396 ARG B CB 1 ATOM 5031 C CG . ARG B 1 330 ? 28.868 97.155 77.943 1.00 40.45 ? 396 ARG B CG 1 ATOM 5032 C CD . ARG B 1 330 ? 28.412 98.575 77.687 1.00 37.25 ? 396 ARG B CD 1 ATOM 5033 N NE . ARG B 1 330 ? 27.286 98.915 78.560 1.00 33.97 ? 396 ARG B NE 1 ATOM 5034 C CZ . ARG B 1 330 ? 27.408 99.508 79.742 1.00 38.84 ? 396 ARG B CZ 1 ATOM 5035 N NH1 . ARG B 1 330 ? 28.605 99.829 80.211 1.00 25.80 ? 396 ARG B NH1 1 ATOM 5036 N NH2 . ARG B 1 330 ? 26.337 99.775 80.466 1.00 36.44 ? 396 ARG B NH2 1 ATOM 5037 N N . ASN B 1 331 ? 32.313 96.710 79.442 1.00 35.86 ? 397 ASN B N 1 ATOM 5038 C CA . ASN B 1 331 ? 32.619 96.715 80.857 1.00 34.60 ? 397 ASN B CA 1 ATOM 5039 C C . ASN B 1 331 ? 34.080 96.960 81.241 1.00 36.88 ? 397 ASN B C 1 ATOM 5040 O O . ASN B 1 331 ? 34.367 97.057 82.432 1.00 35.99 ? 397 ASN B O 1 ATOM 5041 C CB . ASN B 1 331 ? 32.122 95.413 81.466 1.00 29.49 ? 397 ASN B CB 1 ATOM 5042 C CG . ASN B 1 331 ? 30.653 95.306 81.353 1.00 30.24 ? 397 ASN B CG 1 ATOM 5043 O OD1 . ASN B 1 331 ? 29.946 96.239 81.690 1.00 30.58 ? 397 ASN B OD1 1 ATOM 5044 N ND2 . ASN B 1 331 ? 30.157 94.197 80.828 1.00 25.04 ? 397 ASN B ND2 1 ATOM 5045 N N . ASN B 1 332 ? 34.988 97.100 80.270 1.00 33.78 ? 398 ASN B N 1 ATOM 5046 C CA . ASN B 1 332 ? 36.422 97.287 80.526 1.00 33.25 ? 398 ASN B CA 1 ATOM 5047 C C . ASN B 1 332 ? 36.964 96.202 81.428 1.00 35.63 ? 398 ASN B C 1 ATOM 5048 O O . ASN B 1 332 ? 37.489 96.467 82.524 1.00 35.32 ? 398 ASN B O 1 ATOM 5049 C CB . ASN B 1 332 ? 36.757 98.702 81.037 1.00 35.07 ? 398 ASN B CB 1 ATOM 5050 C CG . ASN B 1 332 ? 36.629 99.735 79.962 1.00 51.03 ? 398 ASN B CG 1 ATOM 5051 O OD1 . ASN B 1 332 ? 37.392 99.758 78.975 1.00 41.18 ? 398 ASN B OD1 1 ATOM 5052 N ND2 . ASN B 1 332 ? 35.629 100.590 80.108 1.00 39.28 ? 398 ASN B ND2 1 ATOM 5053 N N . ARG B 1 333 ? 36.822 94.956 80.949 1.00 29.69 ? 399 ARG B N 1 ATOM 5054 C CA . ARG B 1 333 ? 37.260 93.772 81.680 1.00 27.96 ? 399 ARG B CA 1 ATOM 5055 C C . ARG B 1 333 ? 37.629 92.669 80.714 1.00 31.15 ? 399 ARG B C 1 ATOM 5056 O O . ARG B 1 333 ? 37.253 92.705 79.538 1.00 30.21 ? 399 ARG B O 1 ATOM 5057 C CB . ARG B 1 333 ? 36.167 93.298 82.680 1.00 27.24 ? 399 ARG B CB 1 ATOM 5058 C CG . ARG B 1 333 ? 34.880 92.878 82.003 1.00 27.30 ? 399 ARG B CG 1 ATOM 5059 C CD . ARG B 1 333 ? 33.830 92.500 82.987 1.00 30.08 ? 399 ARG B CD 1 ATOM 5060 N NE . ARG B 1 333 ? 32.699 91.892 82.301 1.00 25.87 ? 399 ARG B NE 1 ATOM 5061 C CZ . ARG B 1 333 ? 31.756 91.196 82.909 1.00 36.33 ? 399 ARG B CZ 1 ATOM 5062 N NH1 . ARG B 1 333 ? 31.785 91.039 84.222 1.00 31.14 ? 399 ARG B NH1 1 ATOM 5063 N NH2 . ARG B 1 333 ? 30.764 90.658 82.209 1.00 23.38 ? 399 ARG B NH2 1 ATOM 5064 N N . ILE B 1 334 ? 38.344 91.672 81.227 1.00 29.12 ? 400 ILE B N 1 ATOM 5065 C CA . ILE B 1 334 ? 38.783 90.494 80.487 1.00 28.97 ? 400 ILE B CA 1 ATOM 5066 C C . ILE B 1 334 ? 38.230 89.276 81.196 1.00 34.82 ? 400 ILE B C 1 ATOM 5067 O O . ILE B 1 334 ? 38.353 89.166 82.412 1.00 34.39 ? 400 ILE B O 1 ATOM 5068 C CB . ILE B 1 334 ? 40.332 90.450 80.351 1.00 31.14 ? 400 ILE B CB 1 ATOM 5069 C CG1 . ILE B 1 334 ? 40.861 91.678 79.559 1.00 30.99 ? 400 ILE B CG1 1 ATOM 5070 C CG2 . ILE B 1 334 ? 40.792 89.123 79.706 1.00 30.74 ? 400 ILE B CG2 1 ATOM 5071 C CD1 . ILE B 1 334 ? 42.354 91.946 79.633 1.00 32.06 ? 400 ILE B CD1 1 ATOM 5072 N N . GLY B 1 335 ? 37.642 88.372 80.433 1.00 32.44 ? 401 GLY B N 1 ATOM 5073 C CA . GLY B 1 335 ? 37.135 87.126 80.956 1.00 32.95 ? 401 GLY B CA 1 ATOM 5074 C C . GLY B 1 335 ? 37.990 85.952 80.546 1.00 38.36 ? 401 GLY B C 1 ATOM 5075 O O . GLY B 1 335 ? 38.504 85.910 79.430 1.00 38.59 ? 401 GLY B O 1 ATOM 5076 N N . PHE B 1 336 ? 38.119 84.978 81.441 1.00 33.25 ? 402 PHE B N 1 ATOM 5077 C CA . PHE B 1 336 ? 38.849 83.756 81.175 1.00 31.15 ? 402 PHE B CA 1 ATOM 5078 C C . PHE B 1 336 ? 37.986 82.546 81.530 1.00 36.15 ? 402 PHE B C 1 ATOM 5079 O O . PHE B 1 336 ? 37.238 82.556 82.519 1.00 37.43 ? 402 PHE B O 1 ATOM 5080 C CB . PHE B 1 336 ? 40.156 83.711 81.978 1.00 31.43 ? 402 PHE B CB 1 ATOM 5081 C CG . PHE B 1 336 ? 41.196 84.753 81.649 1.00 31.49 ? 402 PHE B CG 1 ATOM 5082 C CD1 . PHE B 1 336 ? 41.814 84.779 80.401 1.00 32.41 ? 402 PHE B CD1 1 ATOM 5083 C CD2 . PHE B 1 336 ? 41.612 85.670 82.610 1.00 33.78 ? 402 PHE B CD2 1 ATOM 5084 C CE1 . PHE B 1 336 ? 42.788 85.755 80.099 1.00 34.04 ? 402 PHE B CE1 1 ATOM 5085 C CE2 . PHE B 1 336 ? 42.626 86.608 82.330 1.00 35.63 ? 402 PHE B CE2 1 ATOM 5086 C CZ . PHE B 1 336 ? 43.199 86.652 81.074 1.00 33.23 ? 402 PHE B CZ 1 ATOM 5087 N N . ALA B 1 337 ? 38.099 81.504 80.721 1.00 31.55 ? 403 ALA B N 1 ATOM 5088 C CA . ALA B 1 337 ? 37.414 80.235 80.926 1.00 30.97 ? 403 ALA B CA 1 ATOM 5089 C C . ALA B 1 337 ? 38.362 79.188 80.375 1.00 36.58 ? 403 ALA B C 1 ATOM 5090 O O . ALA B 1 337 ? 39.145 79.493 79.477 1.00 36.42 ? 403 ALA B O 1 ATOM 5091 C CB . ALA B 1 337 ? 36.079 80.195 80.190 1.00 30.55 ? 403 ALA B CB 1 ATOM 5092 N N . LEU B 1 338 ? 38.327 77.979 80.932 1.00 33.22 ? 404 LEU B N 1 ATOM 5093 C CA . LEU B 1 338 ? 39.199 76.876 80.540 1.00 33.45 ? 404 LEU B CA 1 ATOM 5094 C C . LEU B 1 338 ? 38.930 76.478 79.086 1.00 37.43 ? 404 LEU B C 1 ATOM 5095 O O . LEU B 1 338 ? 37.788 76.162 78.739 1.00 36.63 ? 404 LEU B O 1 ATOM 5096 C CB . LEU B 1 338 ? 39.022 75.683 81.516 1.00 33.62 ? 404 LEU B CB 1 ATOM 5097 C CG . LEU B 1 338 ? 40.007 74.511 81.335 1.00 39.47 ? 404 LEU B CG 1 ATOM 5098 C CD1 . LEU B 1 338 ? 41.390 74.917 81.708 1.00 38.58 ? 404 LEU B CD1 1 ATOM 5099 C CD2 . LEU B 1 338 ? 39.587 73.301 82.164 1.00 44.31 ? 404 LEU B CD2 1 ATOM 5100 N N . ALA B 1 339 ? 39.982 76.555 78.229 1.00 33.76 ? 405 ALA B N 1 ATOM 5101 C CA . ALA B 1 339 ? 39.844 76.232 76.803 1.00 33.55 ? 405 ALA B CA 1 ATOM 5102 C C . ALA B 1 339 ? 39.715 74.758 76.536 1.00 38.28 ? 405 ALA B C 1 ATOM 5103 O O . ALA B 1 339 ? 40.250 73.931 77.280 1.00 38.16 ? 405 ALA B O 1 ATOM 5104 C CB . ALA B 1 339 ? 41.003 76.796 76.014 1.00 34.31 ? 405 ALA B CB 1 ATOM 5105 N N . ARG B 1 340 ? 39.012 74.412 75.465 1.00 35.79 ? 406 ARG B N 1 ATOM 5106 C CA . ARG B 1 340 ? 38.870 73.006 75.055 1.00 34.20 ? 406 ARG B CA 1 ATOM 5107 C C . ARG B 1 340 ? 38.866 72.888 73.533 1.00 43.95 ? 406 ARG B C 1 ATOM 5108 O O . ARG B 1 340 ? 39.235 71.803 73.044 1.00 52.65 ? 406 ARG B O 1 ATOM 5109 C CB . ARG B 1 340 ? 37.639 72.324 75.705 1.00 31.56 ? 406 ARG B CB 1 ATOM 5110 C CG . ARG B 1 340 ? 36.309 72.889 75.243 1.00 37.82 ? 406 ARG B CG 1 ATOM 5111 C CD . ARG B 1 340 ? 35.164 72.073 75.778 1.00 41.23 ? 406 ARG B CD 1 ATOM 5112 N NE . ARG B 1 340 ? 33.871 72.649 75.400 1.00 41.79 ? 406 ARG B NE 1 ATOM 5113 C CZ . ARG B 1 340 ? 32.876 71.968 74.835 1.00 60.10 ? 406 ARG B CZ 1 ATOM 5114 N NH1 . ARG B 1 340 ? 33.025 70.683 74.531 1.00 58.93 ? 406 ARG B NH1 1 ATOM 5115 N NH2 . ARG B 1 340 ? 31.749 72.581 74.512 1.00 44.23 ? 406 ARG B NH2 1 ATOM 5116 O OXT . ARG B 1 340 ? 38.484 73.865 72.837 1.00 58.37 ? 406 ARG B OXT 1 HETATM 5117 C C1 . NAG C 2 . ? 13.186 47.178 37.259 1.00 56.54 ? 501 NAG A C1 1 HETATM 5118 C C2 . NAG C 2 . ? 12.188 46.270 36.535 1.00 58.82 ? 501 NAG A C2 1 HETATM 5119 C C3 . NAG C 2 . ? 11.724 46.906 35.225 1.00 64.67 ? 501 NAG A C3 1 HETATM 5120 C C4 . NAG C 2 . ? 11.181 48.309 35.480 1.00 69.79 ? 501 NAG A C4 1 HETATM 5121 C C5 . NAG C 2 . ? 12.223 49.160 36.208 1.00 69.50 ? 501 NAG A C5 1 HETATM 5122 C C6 . NAG C 2 . ? 11.708 50.525 36.613 1.00 72.94 ? 501 NAG A C6 1 HETATM 5123 C C7 . NAG C 2 . ? 12.251 43.834 36.949 1.00 53.69 ? 501 NAG A C7 1 HETATM 5124 C C8 . NAG C 2 . ? 12.709 42.518 36.398 1.00 51.66 ? 501 NAG A C8 1 HETATM 5125 N N2 . NAG C 2 . ? 12.696 44.927 36.300 1.00 55.29 ? 501 NAG A N2 1 HETATM 5126 O O3 . NAG C 2 . ? 10.708 46.102 34.631 1.00 65.28 ? 501 NAG A O3 1 HETATM 5127 O O4 . NAG C 2 . ? 10.810 48.914 34.243 1.00 74.07 ? 501 NAG A O4 1 HETATM 5128 O O5 . NAG C 2 . ? 12.645 48.500 37.420 1.00 62.76 ? 501 NAG A O5 1 HETATM 5129 O O6 . NAG C 2 . ? 11.239 51.278 35.495 1.00 75.50 ? 501 NAG A O6 1 HETATM 5130 O O7 . NAG C 2 . ? 11.509 43.905 37.930 1.00 54.81 ? 501 NAG A O7 1 HETATM 5131 C C27 . 70X D 3 . ? 33.888 62.738 50.565 1.00 54.41 ? 502 70X A C27 1 HETATM 5132 C C28 . 70X D 3 . ? 34.892 63.322 49.819 1.00 56.83 ? 502 70X A C28 1 HETATM 5133 C C29 . 70X D 3 . ? 35.764 62.531 49.081 1.00 57.31 ? 502 70X A C29 1 HETATM 5134 C C26 . 70X D 3 . ? 33.786 61.363 50.557 1.00 54.53 ? 502 70X A C26 1 HETATM 5135 C C25 . 70X D 3 . ? 34.661 60.581 49.823 1.00 55.56 ? 502 70X A C25 1 HETATM 5136 C C24 . 70X D 3 . ? 35.672 61.149 49.062 1.00 55.15 ? 502 70X A C24 1 HETATM 5137 C C23 . 70X D 3 . ? 36.651 60.289 48.284 1.00 48.19 ? 502 70X A C23 1 HETATM 5138 C C14 . 70X D 3 . ? 36.403 61.660 42.785 1.00 42.09 ? 502 70X A C14 1 HETATM 5139 C C15 . 70X D 3 . ? 36.476 61.153 44.077 1.00 42.33 ? 502 70X A C15 1 HETATM 5140 C C16 . 70X D 3 . ? 37.688 61.087 44.741 1.00 41.02 ? 502 70X A C16 1 HETATM 5141 C C17 . 70X D 3 . ? 38.826 61.554 44.113 1.00 45.62 ? 502 70X A C17 1 HETATM 5142 C C18 . 70X D 3 . ? 38.761 62.051 42.822 1.00 47.44 ? 502 70X A C18 1 HETATM 5143 C C19 . 70X D 3 . ? 37.549 62.096 42.156 1.00 44.47 ? 502 70X A C19 1 HETATM 5144 C C20 . 70X D 3 . ? 37.821 60.561 46.116 1.00 39.54 ? 502 70X A C20 1 HETATM 5145 N N1 . 70X D 3 . ? 32.191 60.145 43.578 1.00 40.37 ? 502 70X A N1 1 HETATM 5146 C C2 . 70X D 3 . ? 32.644 58.777 43.665 1.00 40.36 ? 502 70X A C2 1 HETATM 5147 C C3 . 70X D 3 . ? 33.384 58.459 42.379 1.00 43.01 ? 502 70X A C3 1 HETATM 5148 C C4 . 70X D 3 . ? 34.373 59.493 41.903 1.00 42.97 ? 502 70X A C4 1 HETATM 5149 N N5 . 70X D 3 . ? 34.127 60.776 42.334 1.00 41.76 ? 502 70X A N5 1 HETATM 5150 C C6 . 70X D 3 . ? 32.892 61.117 42.895 1.00 40.22 ? 502 70X A C6 1 HETATM 5151 N N7 . 70X D 3 . ? 32.413 62.309 42.764 1.00 36.16 ? 502 70X A N7 1 HETATM 5152 O O8 . 70X D 3 . ? 35.307 59.167 41.184 1.00 44.07 ? 502 70X A O8 1 HETATM 5153 C C9 . 70X D 3 . ? 35.123 61.778 42.027 1.00 42.58 ? 502 70X A C9 1 HETATM 5154 C C10 . 70X D 3 . ? 33.534 58.550 44.906 1.00 38.25 ? 502 70X A C10 1 HETATM 5155 C C11 . 70X D 3 . ? 31.382 57.932 43.646 1.00 40.01 ? 502 70X A C11 1 HETATM 5156 C C12 . 70X D 3 . ? 32.974 59.056 46.220 1.00 29.68 ? 502 70X A C12 1 HETATM 5157 C C13 . 70X D 3 . ? 34.026 57.110 45.073 1.00 41.05 ? 502 70X A C13 1 HETATM 5158 O O21 . 70X D 3 . ? 38.938 60.267 46.525 1.00 38.26 ? 502 70X A O21 1 HETATM 5159 N N22 . 70X D 3 . ? 36.653 60.484 46.848 1.00 42.66 ? 502 70X A N22 1 HETATM 5160 C C1 . NAG E 2 . ? 43.783 111.858 56.255 1.00 106.23 ? 501 NAG B C1 1 HETATM 5161 C C2 . NAG E 2 . ? 43.561 113.229 55.613 1.00 109.60 ? 501 NAG B C2 1 HETATM 5162 C C3 . NAG E 2 . ? 43.292 114.279 56.691 1.00 111.32 ? 501 NAG B C3 1 HETATM 5163 C C4 . NAG E 2 . ? 42.124 113.849 57.572 1.00 111.39 ? 501 NAG B C4 1 HETATM 5164 C C5 . NAG E 2 . ? 42.401 112.472 58.174 1.00 110.45 ? 501 NAG B C5 1 HETATM 5165 C C6 . NAG E 2 . ? 41.226 111.910 58.947 1.00 111.61 ? 501 NAG B C6 1 HETATM 5166 C C7 . NAG E 2 . ? 44.599 113.713 53.425 1.00 111.62 ? 501 NAG B C7 1 HETATM 5167 C C8 . NAG E 2 . ? 45.743 114.407 52.749 1.00 111.38 ? 501 NAG B C8 1 HETATM 5168 N N2 . NAG E 2 . ? 44.671 113.637 54.766 1.00 111.09 ? 501 NAG B N2 1 HETATM 5169 O O3 . NAG E 2 . ? 42.994 115.529 56.078 1.00 112.14 ? 501 NAG B O3 1 HETATM 5170 O O4 . NAG E 2 . ? 41.909 114.810 58.603 1.00 111.42 ? 501 NAG B O4 1 HETATM 5171 O O5 . NAG E 2 . ? 42.687 111.528 57.124 1.00 108.17 ? 501 NAG B O5 1 HETATM 5172 O O6 . NAG E 2 . ? 40.841 112.751 60.029 1.00 112.88 ? 501 NAG B O6 1 HETATM 5173 O O7 . NAG E 2 . ? 43.651 113.256 52.791 1.00 111.75 ? 501 NAG B O7 1 HETATM 5174 C C27 . 70X F 3 . ? 50.293 85.628 67.518 1.00 47.77 ? 502 70X B C27 1 HETATM 5175 C C28 . 70X F 3 . ? 50.837 86.086 66.336 1.00 50.17 ? 502 70X B C28 1 HETATM 5176 C C29 . 70X F 3 . ? 52.163 86.472 66.253 1.00 52.61 ? 502 70X B C29 1 HETATM 5177 C C26 . 70X F 3 . ? 51.085 85.556 68.641 1.00 50.13 ? 502 70X B C26 1 HETATM 5178 C C25 . 70X F 3 . ? 52.414 85.938 68.558 1.00 54.53 ? 502 70X B C25 1 HETATM 5179 C C24 . 70X F 3 . ? 52.970 86.406 67.374 1.00 53.85 ? 502 70X B C24 1 HETATM 5180 C C23 . 70X F 3 . ? 54.412 86.809 67.292 1.00 49.15 ? 502 70X B C23 1 HETATM 5181 C C14 . 70X F 3 . ? 55.332 91.003 71.022 1.00 48.67 ? 502 70X B C14 1 HETATM 5182 C C15 . 70X F 3 . ? 55.220 90.171 69.919 1.00 50.78 ? 502 70X B C15 1 HETATM 5183 C C16 . 70X F 3 . ? 56.107 89.128 69.721 1.00 52.32 ? 502 70X B C16 1 HETATM 5184 C C17 . 70X F 3 . ? 57.120 88.923 70.636 1.00 55.83 ? 502 70X B C17 1 HETATM 5185 C C18 . 70X F 3 . ? 57.239 89.752 71.739 1.00 56.00 ? 502 70X B C18 1 HETATM 5186 C C19 . 70X F 3 . ? 56.347 90.791 71.932 1.00 52.91 ? 502 70X B C19 1 HETATM 5187 C C20 . 70X F 3 . ? 56.002 88.218 68.561 1.00 50.89 ? 502 70X B C20 1 HETATM 5188 N N1 . 70X F 3 . ? 52.249 93.059 68.409 1.00 43.39 ? 502 70X B N1 1 HETATM 5189 C C2 . 70X F 3 . ? 53.236 93.308 67.358 1.00 41.59 ? 502 70X B C2 1 HETATM 5190 C C3 . 70X F 3 . ? 54.353 94.093 68.028 1.00 41.58 ? 502 70X B C3 1 HETATM 5191 C C4 . 70X F 3 . ? 54.858 93.488 69.316 1.00 44.16 ? 502 70X B C4 1 HETATM 5192 N N5 . 70X F 3 . ? 53.918 92.796 70.083 1.00 43.33 ? 502 70X B N5 1 HETATM 5193 C C6 . 70X F 3 . ? 52.579 92.737 69.710 1.00 42.25 ? 502 70X B C6 1 HETATM 5194 N N7 . 70X F 3 . ? 51.680 92.409 70.575 1.00 40.59 ? 502 70X B N7 1 HETATM 5195 O O8 . 70X F 3 . ? 56.036 93.622 69.623 1.00 45.10 ? 502 70X B O8 1 HETATM 5196 C C9 . 70X F 3 . ? 54.374 92.121 71.278 1.00 44.60 ? 502 70X B C9 1 HETATM 5197 C C10 . 70X F 3 . ? 53.718 91.982 66.719 1.00 37.93 ? 502 70X B C10 1 HETATM 5198 C C11 . 70X F 3 . ? 52.564 94.224 66.347 1.00 39.93 ? 502 70X B C11 1 HETATM 5199 C C12 . 70X F 3 . ? 52.616 90.973 66.439 1.00 34.70 ? 502 70X B C12 1 HETATM 5200 C C13 . 70X F 3 . ? 54.615 92.119 65.506 1.00 34.40 ? 502 70X B C13 1 HETATM 5201 O O21 . 70X F 3 . ? 57.022 87.767 68.062 1.00 54.47 ? 502 70X B O21 1 HETATM 5202 N N22 . 70X F 3 . ? 54.723 87.941 68.130 1.00 47.79 ? 502 70X B N22 1 HETATM 5203 O O . HOH G 4 . ? 41.101 55.057 42.705 1.00 44.60 ? 601 HOH A O 1 HETATM 5204 O O . HOH G 4 . ? 39.121 38.317 50.111 1.00 33.07 ? 602 HOH A O 1 HETATM 5205 O O . HOH G 4 . ? 15.720 38.726 45.040 1.00 38.87 ? 603 HOH A O 1 HETATM 5206 O O . HOH G 4 . ? 35.861 53.585 35.692 1.00 32.44 ? 604 HOH A O 1 HETATM 5207 O O . HOH G 4 . ? 38.352 49.697 54.240 1.00 45.13 ? 605 HOH A O 1 HETATM 5208 O O . HOH G 4 . ? 8.307 42.943 50.229 1.00 37.77 ? 606 HOH A O 1 HETATM 5209 O O . HOH G 4 . ? 10.849 41.933 39.784 1.00 38.11 ? 607 HOH A O 1 HETATM 5210 O O . HOH G 4 . ? 11.318 46.589 40.388 1.00 44.81 ? 608 HOH A O 1 HETATM 5211 O O . HOH G 4 . ? 40.141 61.103 60.833 1.00 34.85 ? 609 HOH A O 1 HETATM 5212 O O . HOH G 4 . ? 31.877 42.321 35.021 1.00 43.52 ? 610 HOH A O 1 HETATM 5213 O O . HOH G 4 . ? 36.750 49.339 56.323 1.00 40.90 ? 611 HOH A O 1 HETATM 5214 O O . HOH G 4 . ? 34.108 48.810 32.542 1.00 38.24 ? 612 HOH A O 1 HETATM 5215 O O . HOH G 4 . ? 32.710 33.347 46.194 1.00 69.94 ? 613 HOH A O 1 HETATM 5216 O O . HOH G 4 . ? 39.855 41.722 45.793 1.00 34.70 ? 614 HOH A O 1 HETATM 5217 O O . HOH G 4 . ? 40.389 37.979 43.979 1.00 50.70 ? 615 HOH A O 1 HETATM 5218 O O . HOH G 4 . ? 41.871 46.351 42.660 1.00 49.53 ? 616 HOH A O 1 HETATM 5219 O O . HOH G 4 . ? 39.755 43.427 43.533 1.00 27.99 ? 617 HOH A O 1 HETATM 5220 O O . HOH G 4 . ? 12.199 37.046 41.540 1.00 62.99 ? 618 HOH A O 1 HETATM 5221 O O . HOH G 4 . ? 33.346 36.804 54.317 1.00 45.79 ? 619 HOH A O 1 HETATM 5222 O O . HOH G 4 . ? 44.556 40.999 57.815 1.00 51.85 ? 620 HOH A O 1 HETATM 5223 O O . HOH G 4 . ? 35.983 37.037 42.066 1.00 45.31 ? 621 HOH A O 1 HETATM 5224 O O . HOH G 4 . ? 37.832 38.964 41.937 1.00 58.02 ? 622 HOH A O 1 HETATM 5225 O O . HOH G 4 . ? 43.727 43.727 43.727 0.33 53.94 ? 623 HOH A O 1 HETATM 5226 O O . HOH G 4 . ? 33.292 51.276 50.198 1.00 21.87 ? 624 HOH A O 1 HETATM 5227 O O . HOH G 4 . ? 31.459 42.096 55.396 1.00 41.38 ? 625 HOH A O 1 HETATM 5228 O O . HOH G 4 . ? 49.593 85.222 47.624 1.00 30.20 ? 626 HOH A O 1 HETATM 5229 O O . HOH G 4 . ? 27.809 79.035 35.199 1.00 40.35 ? 627 HOH A O 1 HETATM 5230 O O . HOH G 4 . ? 34.279 63.425 62.530 1.00 29.11 ? 628 HOH A O 1 HETATM 5231 O O . HOH G 4 . ? 37.652 84.349 49.332 1.00 41.91 ? 629 HOH A O 1 HETATM 5232 O O . HOH G 4 . ? 49.088 81.428 51.263 1.00 35.84 ? 630 HOH A O 1 HETATM 5233 O O . HOH G 4 . ? 51.292 65.945 54.094 1.00 37.13 ? 631 HOH A O 1 HETATM 5234 O O . HOH G 4 . ? 26.899 54.669 60.503 1.00 63.42 ? 632 HOH A O 1 HETATM 5235 O O . HOH G 4 . ? 13.250 54.447 39.702 1.00 46.44 ? 633 HOH A O 1 HETATM 5236 O O . HOH G 4 . ? 18.715 81.012 39.002 1.00 57.65 ? 634 HOH A O 1 HETATM 5237 O O . HOH G 4 . ? 34.816 62.794 38.452 1.00 29.57 ? 635 HOH A O 1 HETATM 5238 O O . HOH G 4 . ? 16.751 44.084 57.305 1.00 28.42 ? 636 HOH A O 1 HETATM 5239 O O . HOH G 4 . ? 16.901 42.842 43.149 1.00 23.66 ? 637 HOH A O 1 HETATM 5240 O O . HOH G 4 . ? 31.800 73.718 54.769 1.00 33.85 ? 638 HOH A O 1 HETATM 5241 O O . HOH G 4 . ? 21.241 41.006 49.268 1.00 28.12 ? 639 HOH A O 1 HETATM 5242 O O . HOH G 4 . ? 26.467 56.998 42.460 1.00 32.66 ? 640 HOH A O 1 HETATM 5243 O O . HOH G 4 . ? 37.933 43.941 46.775 1.00 27.39 ? 641 HOH A O 1 HETATM 5244 O O . HOH G 4 . ? 19.014 40.889 46.328 1.00 30.16 ? 642 HOH A O 1 HETATM 5245 O O . HOH G 4 . ? 19.697 66.728 43.238 1.00 27.77 ? 643 HOH A O 1 HETATM 5246 O O . HOH G 4 . ? 38.013 65.118 40.724 1.00 37.38 ? 644 HOH A O 1 HETATM 5247 O O . HOH G 4 . ? 41.020 67.034 51.218 1.00 32.49 ? 645 HOH A O 1 HETATM 5248 O O . HOH G 4 . ? 40.785 58.885 50.919 1.00 47.44 ? 646 HOH A O 1 HETATM 5249 O O . HOH G 4 . ? 29.468 63.183 52.188 1.00 30.77 ? 647 HOH A O 1 HETATM 5250 O O . HOH G 4 . ? 24.886 71.950 56.583 1.00 31.14 ? 648 HOH A O 1 HETATM 5251 O O . HOH G 4 . ? 30.508 38.849 43.056 1.00 35.00 ? 649 HOH A O 1 HETATM 5252 O O . HOH G 4 . ? 27.721 42.822 56.581 1.00 33.94 ? 650 HOH A O 1 HETATM 5253 O O . HOH G 4 . ? 19.793 54.976 42.623 1.00 28.61 ? 651 HOH A O 1 HETATM 5254 O O . HOH G 4 . ? 20.628 59.197 43.788 1.00 32.42 ? 652 HOH A O 1 HETATM 5255 O O . HOH G 4 . ? 40.118 63.731 45.555 1.00 58.38 ? 653 HOH A O 1 HETATM 5256 O O . HOH G 4 . ? 23.475 44.715 56.371 1.00 33.86 ? 654 HOH A O 1 HETATM 5257 O O . HOH G 4 . ? 19.535 57.018 40.807 1.00 30.48 ? 655 HOH A O 1 HETATM 5258 O O . HOH G 4 . ? 19.627 62.660 44.558 1.00 29.95 ? 656 HOH A O 1 HETATM 5259 O O . HOH G 4 . ? 39.452 67.819 36.996 1.00 33.35 ? 657 HOH A O 1 HETATM 5260 O O . HOH G 4 . ? 21.425 53.079 41.580 1.00 29.91 ? 658 HOH A O 1 HETATM 5261 O O . HOH G 4 . ? 25.823 83.208 36.980 1.00 44.78 ? 659 HOH A O 1 HETATM 5262 O O . HOH G 4 . ? 47.952 64.690 40.552 1.00 43.93 ? 660 HOH A O 1 HETATM 5263 O O . HOH G 4 . ? 35.718 79.029 56.172 1.00 35.42 ? 661 HOH A O 1 HETATM 5264 O O . HOH G 4 . ? 30.256 83.886 48.867 1.00 42.26 ? 662 HOH A O 1 HETATM 5265 O O . HOH G 4 . ? 18.801 57.010 58.989 1.00 44.98 ? 663 HOH A O 1 HETATM 5266 O O . HOH G 4 . ? 8.582 57.306 49.245 1.00 43.28 ? 664 HOH A O 1 HETATM 5267 O O . HOH G 4 . ? 48.291 66.244 45.375 1.00 33.25 ? 665 HOH A O 1 HETATM 5268 O O . HOH G 4 . ? 19.250 45.075 60.794 1.00 38.00 ? 666 HOH A O 1 HETATM 5269 O O . HOH G 4 . ? 25.879 62.965 38.324 1.00 41.80 ? 667 HOH A O 1 HETATM 5270 O O . HOH G 4 . ? 39.158 67.515 33.204 1.00 32.35 ? 668 HOH A O 1 HETATM 5271 O O . HOH G 4 . ? 37.380 73.254 31.900 1.00 44.79 ? 669 HOH A O 1 HETATM 5272 O O . HOH G 4 . ? 20.273 59.193 58.525 1.00 32.43 ? 670 HOH A O 1 HETATM 5273 O O . HOH G 4 . ? 24.683 60.229 59.883 1.00 40.69 ? 671 HOH A O 1 HETATM 5274 O O . HOH G 4 . ? 28.174 57.012 59.935 1.00 35.87 ? 672 HOH A O 1 HETATM 5275 O O . HOH G 4 . ? 37.957 80.684 56.636 1.00 44.93 ? 673 HOH A O 1 HETATM 5276 O O . HOH G 4 . ? 34.654 81.520 59.422 1.00 40.37 ? 674 HOH A O 1 HETATM 5277 O O . HOH G 4 . ? 25.877 58.348 38.737 1.00 33.62 ? 675 HOH A O 1 HETATM 5278 O O . HOH G 4 . ? 29.820 84.748 53.045 1.00 39.98 ? 676 HOH A O 1 HETATM 5279 O O . HOH G 4 . ? 14.131 55.376 42.750 1.00 33.73 ? 677 HOH A O 1 HETATM 5280 O O . HOH G 4 . ? 33.291 60.230 38.518 1.00 62.23 ? 678 HOH A O 1 HETATM 5281 O O . HOH G 4 . ? 29.530 70.493 30.329 1.00 47.45 ? 679 HOH A O 1 HETATM 5282 O O . HOH G 4 . ? 14.855 51.527 56.517 1.00 37.81 ? 680 HOH A O 1 HETATM 5283 O O . HOH G 4 . ? 30.436 64.048 37.942 1.00 38.85 ? 681 HOH A O 1 HETATM 5284 O O . HOH G 4 . ? 40.294 73.379 52.900 1.00 32.62 ? 682 HOH A O 1 HETATM 5285 O O . HOH G 4 . ? 24.335 65.391 37.879 1.00 32.52 ? 683 HOH A O 1 HETATM 5286 O O . HOH G 4 . ? 51.098 76.593 59.499 1.00 50.24 ? 684 HOH A O 1 HETATM 5287 O O . HOH G 4 . ? 41.148 67.023 31.130 1.00 51.66 ? 685 HOH A O 1 HETATM 5288 O O . HOH G 4 . ? 41.411 60.352 48.741 1.00 53.47 ? 686 HOH A O 1 HETATM 5289 O O . HOH G 4 . ? 39.174 65.564 43.120 1.00 49.18 ? 687 HOH A O 1 HETATM 5290 O O . HOH G 4 . ? 22.209 62.763 61.949 1.00 40.45 ? 688 HOH A O 1 HETATM 5291 O O . HOH G 4 . ? 26.528 51.758 59.689 1.00 34.00 ? 689 HOH A O 1 HETATM 5292 O O . HOH G 4 . ? 59.047 72.095 48.086 1.00 66.52 ? 690 HOH A O 1 HETATM 5293 O O . HOH G 4 . ? 26.411 66.619 39.119 1.00 33.42 ? 691 HOH A O 1 HETATM 5294 O O . HOH G 4 . ? 24.589 49.885 33.498 1.00 41.42 ? 692 HOH A O 1 HETATM 5295 O O . HOH G 4 . ? 29.862 84.151 43.432 1.00 47.83 ? 693 HOH A O 1 HETATM 5296 O O . HOH G 4 . ? 28.516 50.444 58.413 1.00 33.67 ? 694 HOH A O 1 HETATM 5297 O O . HOH G 4 . ? 17.164 65.342 38.809 1.00 40.07 ? 695 HOH A O 1 HETATM 5298 O O . HOH G 4 . ? 19.734 43.094 33.200 1.00 39.01 ? 696 HOH A O 1 HETATM 5299 O O . HOH G 4 . ? 32.128 49.495 57.266 1.00 36.80 ? 697 HOH A O 1 HETATM 5300 O O . HOH G 4 . ? 35.414 64.876 40.213 1.00 39.09 ? 698 HOH A O 1 HETATM 5301 O O . HOH G 4 . ? 18.846 64.312 42.529 1.00 45.25 ? 699 HOH A O 1 HETATM 5302 O O . HOH G 4 . ? 28.131 65.126 37.224 1.00 43.96 ? 700 HOH A O 1 HETATM 5303 O O . HOH G 4 . ? 18.386 42.988 59.139 1.00 28.98 ? 701 HOH A O 1 HETATM 5304 O O . HOH G 4 . ? 43.754 65.510 59.039 1.00 48.89 ? 702 HOH A O 1 HETATM 5305 O O . HOH G 4 . ? 41.976 73.252 56.220 1.00 57.27 ? 703 HOH A O 1 HETATM 5306 O O . HOH G 4 . ? 10.185 48.853 48.805 1.00 39.40 ? 704 HOH A O 1 HETATM 5307 O O . HOH G 4 . ? 11.230 65.334 41.888 1.00 48.30 ? 705 HOH A O 1 HETATM 5308 O O . HOH G 4 . ? 22.257 46.236 31.907 1.00 60.46 ? 706 HOH A O 1 HETATM 5309 O O . HOH G 4 . ? 41.959 71.097 57.980 1.00 83.32 ? 707 HOH A O 1 HETATM 5310 O O . HOH G 4 . ? 58.314 77.011 58.034 1.00 52.62 ? 708 HOH A O 1 HETATM 5311 O O . HOH G 4 . ? 22.726 47.504 60.565 1.00 34.91 ? 709 HOH A O 1 HETATM 5312 O O . HOH G 4 . ? 20.826 41.798 57.974 1.00 39.42 ? 710 HOH A O 1 HETATM 5313 O O . HOH G 4 . ? 9.794 67.654 49.496 1.00 57.31 ? 711 HOH A O 1 HETATM 5314 O O . HOH G 4 . ? 35.315 89.558 44.710 1.00 45.25 ? 712 HOH A O 1 HETATM 5315 O O . HOH G 4 . ? 31.145 82.329 36.592 1.00 49.42 ? 713 HOH A O 1 HETATM 5316 O O . HOH G 4 . ? 27.863 82.186 35.404 1.00 46.99 ? 714 HOH A O 1 HETATM 5317 O O . HOH G 4 . ? 45.593 84.566 44.312 1.00 55.60 ? 715 HOH A O 1 HETATM 5318 O O . HOH G 4 . ? 19.373 49.155 62.738 1.00 50.76 ? 716 HOH A O 1 HETATM 5319 O O . HOH G 4 . ? 35.095 74.409 57.775 1.00 45.59 ? 717 HOH A O 1 HETATM 5320 O O . HOH G 4 . ? 24.656 86.315 44.255 1.00 36.40 ? 718 HOH A O 1 HETATM 5321 O O . HOH G 4 . ? 19.822 55.024 60.446 1.00 48.06 ? 719 HOH A O 1 HETATM 5322 O O . HOH G 4 . ? 40.146 75.182 54.908 1.00 39.07 ? 720 HOH A O 1 HETATM 5323 O O . HOH G 4 . ? 20.116 78.898 36.198 1.00 45.26 ? 721 HOH A O 1 HETATM 5324 O O . HOH G 4 . ? 21.984 48.008 63.140 1.00 65.01 ? 722 HOH A O 1 HETATM 5325 O O . HOH G 4 . ? 36.312 63.660 65.892 1.00 54.48 ? 723 HOH A O 1 HETATM 5326 O O . HOH G 4 . ? 12.618 75.729 46.652 1.00 39.25 ? 724 HOH A O 1 HETATM 5327 O O . HOH G 4 . ? 21.808 54.382 64.259 1.00 57.27 ? 725 HOH A O 1 HETATM 5328 O O . HOH G 4 . ? 50.386 75.538 55.515 1.00 54.33 ? 726 HOH A O 1 HETATM 5329 O O . HOH G 4 . ? 43.335 61.862 35.122 1.00 47.26 ? 727 HOH A O 1 HETATM 5330 O O . HOH G 4 . ? 26.933 43.006 37.252 1.00 51.24 ? 728 HOH A O 1 HETATM 5331 O O . HOH G 4 . ? 20.847 36.968 50.357 1.00 62.36 ? 729 HOH A O 1 HETATM 5332 O O . HOH G 4 . ? 44.884 67.855 29.699 1.00 51.84 ? 730 HOH A O 1 HETATM 5333 O O . HOH G 4 . ? 13.493 70.325 41.101 1.00 52.40 ? 731 HOH A O 1 HETATM 5334 O O . HOH G 4 . ? 16.608 71.621 38.636 1.00 53.07 ? 732 HOH A O 1 HETATM 5335 O O . HOH G 4 . ? 15.267 83.501 43.628 1.00 53.05 ? 733 HOH A O 1 HETATM 5336 O O . HOH G 4 . ? 34.520 59.043 34.293 1.00 62.41 ? 734 HOH A O 1 HETATM 5337 O O . HOH G 4 . ? 18.228 40.286 42.251 1.00 43.77 ? 735 HOH A O 1 HETATM 5338 O O . HOH G 4 . ? 34.829 71.391 28.221 1.00 61.62 ? 736 HOH A O 1 HETATM 5339 O O . HOH G 4 . ? 36.456 67.668 62.091 1.00 46.29 ? 737 HOH A O 1 HETATM 5340 O O . HOH G 4 . ? 36.010 65.349 63.353 1.00 59.57 ? 738 HOH A O 1 HETATM 5341 O O . HOH G 4 . ? 34.564 50.777 57.065 1.00 45.42 ? 739 HOH A O 1 HETATM 5342 O O . HOH G 4 . ? 16.920 58.513 60.209 1.00 39.03 ? 740 HOH A O 1 HETATM 5343 O O . HOH G 4 . ? 42.747 75.870 33.136 1.00 60.74 ? 741 HOH A O 1 HETATM 5344 O O . HOH G 4 . ? 23.125 43.202 58.552 1.00 39.59 ? 742 HOH A O 1 HETATM 5345 O O . HOH G 4 . ? 22.152 44.933 60.582 1.00 52.92 ? 743 HOH A O 1 HETATM 5346 O O . HOH G 4 . ? 28.364 60.316 61.051 1.00 57.10 ? 744 HOH A O 1 HETATM 5347 O O . HOH G 4 . ? 51.512 59.538 45.379 1.00 59.49 ? 745 HOH A O 1 HETATM 5348 O O . HOH G 4 . ? 42.950 83.967 35.013 1.00 49.87 ? 746 HOH A O 1 HETATM 5349 O O . HOH G 4 . ? 25.335 71.776 63.558 1.00 44.67 ? 747 HOH A O 1 HETATM 5350 O O . HOH G 4 . ? 45.887 61.668 41.056 1.00 53.87 ? 748 HOH A O 1 HETATM 5351 O O . HOH G 4 . ? 9.293 61.091 54.697 1.00 49.77 ? 749 HOH A O 1 HETATM 5352 O O . HOH G 4 . ? 23.858 50.524 63.185 1.00 59.48 ? 750 HOH A O 1 HETATM 5353 O O . HOH G 4 . ? 58.114 69.642 62.811 1.00 50.67 ? 751 HOH A O 1 HETATM 5354 O O . HOH G 4 . ? 31.560 62.608 31.403 1.00 57.30 ? 752 HOH A O 1 HETATM 5355 O O . HOH G 4 . ? 30.449 59.640 38.267 1.00 45.26 ? 753 HOH A O 1 HETATM 5356 O O . HOH G 4 . ? 22.599 54.328 31.307 1.00 42.83 ? 754 HOH A O 1 HETATM 5357 O O . HOH G 4 . ? 27.706 88.140 43.351 1.00 47.94 ? 755 HOH A O 1 HETATM 5358 O O . HOH G 4 . ? 22.853 67.850 31.710 1.00 58.43 ? 756 HOH A O 1 HETATM 5359 O O . HOH G 4 . ? 17.102 77.228 54.617 1.00 53.80 ? 757 HOH A O 1 HETATM 5360 O O . HOH G 4 . ? 16.413 77.489 36.436 1.00 53.48 ? 758 HOH A O 1 HETATM 5361 O O . HOH G 4 . ? 15.252 80.821 38.641 1.00 55.78 ? 759 HOH A O 1 HETATM 5362 O O . HOH G 4 . ? 21.135 49.641 34.598 1.00 46.59 ? 760 HOH A O 1 HETATM 5363 O O . HOH G 4 . ? 25.135 46.820 32.658 1.00 61.01 ? 761 HOH A O 1 HETATM 5364 O O . HOH G 4 . ? 37.671 55.738 47.530 1.00 37.53 ? 762 HOH A O 1 HETATM 5365 O O . HOH G 4 . ? 44.247 71.199 54.465 1.00 48.95 ? 763 HOH A O 1 HETATM 5366 O O . HOH G 4 . ? 41.210 72.072 33.909 1.00 38.92 ? 764 HOH A O 1 HETATM 5367 O O . HOH G 4 . ? 26.031 40.631 40.053 1.00 46.35 ? 765 HOH A O 1 HETATM 5368 O O . HOH H 4 . ? 30.925 90.008 79.279 1.00 29.34 ? 601 HOH B O 1 HETATM 5369 O O . HOH H 4 . ? 33.576 95.771 84.664 1.00 25.87 ? 602 HOH B O 1 HETATM 5370 O O . HOH H 4 . ? 61.773 72.599 73.029 1.00 42.61 ? 603 HOH B O 1 HETATM 5371 O O . HOH H 4 . ? 28.156 94.224 75.272 1.00 39.96 ? 604 HOH B O 1 HETATM 5372 O O . HOH H 4 . ? 38.071 90.247 89.231 1.00 37.10 ? 605 HOH B O 1 HETATM 5373 O O . HOH H 4 . ? 29.704 93.233 77.450 1.00 33.13 ? 606 HOH B O 1 HETATM 5374 O O . HOH H 4 . ? 57.903 82.404 65.677 1.00 47.53 ? 607 HOH B O 1 HETATM 5375 O O . HOH H 4 . ? 32.164 82.851 87.111 1.00 46.74 ? 608 HOH B O 1 HETATM 5376 O O . HOH H 4 . ? 26.356 80.482 81.382 1.00 52.41 ? 609 HOH B O 1 HETATM 5377 O O . HOH H 4 . ? 30.039 85.669 77.224 1.00 51.32 ? 610 HOH B O 1 HETATM 5378 O O . HOH H 4 . ? 25.270 98.145 76.695 1.00 46.85 ? 611 HOH B O 1 HETATM 5379 O O . HOH H 4 . ? 30.178 84.057 83.575 1.00 35.87 ? 612 HOH B O 1 HETATM 5380 O O . HOH H 4 . ? 33.327 92.593 86.253 1.00 35.96 ? 613 HOH B O 1 HETATM 5381 O O . HOH H 4 . ? 30.274 82.171 81.151 1.00 43.19 ? 614 HOH B O 1 HETATM 5382 O O . HOH H 4 . ? 33.309 94.393 88.515 1.00 38.37 ? 615 HOH B O 1 HETATM 5383 O O . HOH H 4 . ? 69.138 69.036 72.590 1.00 44.12 ? 616 HOH B O 1 HETATM 5384 O O . HOH H 4 . ? 38.726 92.867 89.111 1.00 25.04 ? 617 HOH B O 1 HETATM 5385 O O . HOH H 4 . ? 23.628 99.449 79.000 1.00 49.54 ? 618 HOH B O 1 HETATM 5386 O O . HOH H 4 . ? 55.229 73.562 68.860 1.00 49.33 ? 619 HOH B O 1 HETATM 5387 O O . HOH H 4 . ? 33.983 81.006 87.510 1.00 43.99 ? 620 HOH B O 1 HETATM 5388 O O . HOH H 4 . ? 63.257 60.455 72.104 1.00 43.73 ? 621 HOH B O 1 HETATM 5389 O O . HOH H 4 . ? 54.194 79.797 72.552 1.00 29.46 ? 622 HOH B O 1 HETATM 5390 O O . HOH H 4 . ? 53.314 76.044 75.533 1.00 33.71 ? 623 HOH B O 1 HETATM 5391 O O . HOH H 4 . ? 64.339 84.790 78.041 1.00 27.42 ? 624 HOH B O 1 HETATM 5392 O O . HOH H 4 . ? 31.245 99.736 54.357 1.00 56.19 ? 625 HOH B O 1 HETATM 5393 O O . HOH H 4 . ? 31.539 100.877 57.737 1.00 35.31 ? 626 HOH B O 1 HETATM 5394 O O . HOH H 4 . ? 41.158 79.995 92.724 1.00 46.42 ? 627 HOH B O 1 HETATM 5395 O O . HOH H 4 . ? 53.279 73.480 75.285 1.00 50.91 ? 628 HOH B O 1 HETATM 5396 O O . HOH H 4 . ? 33.150 77.565 85.712 1.00 41.80 ? 629 HOH B O 1 HETATM 5397 O O . HOH H 4 . ? 46.875 75.556 62.169 1.00 34.79 ? 630 HOH B O 1 HETATM 5398 O O . HOH H 4 . ? 42.350 79.204 73.688 1.00 27.30 ? 631 HOH B O 1 HETATM 5399 O O . HOH H 4 . ? 36.859 81.828 69.527 1.00 24.56 ? 632 HOH B O 1 HETATM 5400 O O . HOH H 4 . ? 69.180 78.833 73.183 1.00 30.18 ? 633 HOH B O 1 HETATM 5401 O O . HOH H 4 . ? 42.652 94.691 87.489 1.00 34.84 ? 634 HOH B O 1 HETATM 5402 O O . HOH H 4 . ? 57.148 90.971 80.345 1.00 40.55 ? 635 HOH B O 1 HETATM 5403 O O . HOH H 4 . ? 45.978 86.419 65.993 1.00 40.22 ? 636 HOH B O 1 HETATM 5404 O O . HOH H 4 . ? 53.344 70.667 86.514 1.00 42.71 ? 637 HOH B O 1 HETATM 5405 O O . HOH H 4 . ? 36.406 77.479 83.087 1.00 41.37 ? 638 HOH B O 1 HETATM 5406 O O . HOH H 4 . ? 49.090 97.757 65.148 1.00 41.94 ? 639 HOH B O 1 HETATM 5407 O O . HOH H 4 . ? 55.042 94.440 74.220 1.00 39.71 ? 640 HOH B O 1 HETATM 5408 O O . HOH H 4 . ? 46.372 96.939 74.817 1.00 34.65 ? 641 HOH B O 1 HETATM 5409 O O . HOH H 4 . ? 40.805 83.412 58.085 1.00 35.19 ? 642 HOH B O 1 HETATM 5410 O O . HOH H 4 . ? 37.187 82.271 58.785 1.00 37.70 ? 643 HOH B O 1 HETATM 5411 O O . HOH H 4 . ? 40.276 97.356 66.936 1.00 48.02 ? 644 HOH B O 1 HETATM 5412 O O . HOH H 4 . ? 44.404 98.799 82.118 1.00 39.53 ? 645 HOH B O 1 HETATM 5413 O O . HOH H 4 . ? 45.109 99.195 74.067 1.00 34.93 ? 646 HOH B O 1 HETATM 5414 O O . HOH H 4 . ? 49.845 76.836 77.379 1.00 45.15 ? 647 HOH B O 1 HETATM 5415 O O . HOH H 4 . ? 43.438 91.064 89.969 1.00 33.33 ? 648 HOH B O 1 HETATM 5416 O O . HOH H 4 . ? 25.443 85.775 63.034 1.00 38.18 ? 649 HOH B O 1 HETATM 5417 O O . HOH H 4 . ? 37.955 87.029 57.056 1.00 32.82 ? 650 HOH B O 1 HETATM 5418 O O . HOH H 4 . ? 56.394 86.746 72.454 1.00 47.78 ? 651 HOH B O 1 HETATM 5419 O O . HOH H 4 . ? 42.740 74.294 78.577 1.00 43.00 ? 652 HOH B O 1 HETATM 5420 O O . HOH H 4 . ? 43.511 77.413 87.335 1.00 36.82 ? 653 HOH B O 1 HETATM 5421 O O . HOH H 4 . ? 55.725 87.446 74.960 1.00 46.59 ? 654 HOH B O 1 HETATM 5422 O O . HOH H 4 . ? 38.908 102.462 71.551 1.00 56.52 ? 655 HOH B O 1 HETATM 5423 O O . HOH H 4 . ? 39.080 96.668 71.199 1.00 41.16 ? 656 HOH B O 1 HETATM 5424 O O . HOH H 4 . ? 42.237 73.418 72.862 1.00 44.13 ? 657 HOH B O 1 HETATM 5425 O O . HOH H 4 . ? 43.639 75.567 73.543 1.00 39.85 ? 658 HOH B O 1 HETATM 5426 O O . HOH H 4 . ? 55.625 90.009 75.801 1.00 32.45 ? 659 HOH B O 1 HETATM 5427 O O . HOH H 4 . ? 53.891 91.909 74.881 1.00 40.95 ? 660 HOH B O 1 HETATM 5428 O O . HOH H 4 . ? 49.506 100.720 67.835 1.00 46.90 ? 661 HOH B O 1 HETATM 5429 O O . HOH H 4 . ? 44.446 101.478 61.828 1.00 40.86 ? 662 HOH B O 1 HETATM 5430 O O . HOH H 4 . ? 30.944 75.564 77.422 1.00 60.63 ? 663 HOH B O 1 HETATM 5431 O O . HOH H 4 . ? 38.285 84.279 57.311 1.00 38.31 ? 664 HOH B O 1 HETATM 5432 O O . HOH H 4 . ? 49.500 100.559 46.843 1.00 39.93 ? 665 HOH B O 1 HETATM 5433 O O . HOH H 4 . ? 39.469 98.729 69.314 1.00 42.40 ? 666 HOH B O 1 HETATM 5434 O O . HOH H 4 . ? 41.702 93.120 89.732 1.00 36.23 ? 667 HOH B O 1 HETATM 5435 O O . HOH H 4 . ? 27.240 87.349 71.657 1.00 37.71 ? 668 HOH B O 1 HETATM 5436 O O . HOH H 4 . ? 53.256 71.694 91.172 1.00 42.64 ? 669 HOH B O 1 HETATM 5437 O O . HOH H 4 . ? 28.570 74.539 75.872 1.00 53.68 ? 670 HOH B O 1 HETATM 5438 O O . HOH H 4 . ? 46.663 80.934 56.558 1.00 49.48 ? 671 HOH B O 1 HETATM 5439 O O . HOH H 4 . ? 42.938 98.745 64.558 1.00 36.85 ? 672 HOH B O 1 HETATM 5440 O O . HOH H 4 . ? 37.989 81.457 84.887 1.00 45.14 ? 673 HOH B O 1 HETATM 5441 O O . HOH H 4 . ? 29.082 87.851 60.292 1.00 47.05 ? 674 HOH B O 1 HETATM 5442 O O . HOH H 4 . ? 44.088 72.297 79.753 1.00 44.74 ? 675 HOH B O 1 HETATM 5443 O O . HOH H 4 . ? 51.135 76.842 91.543 1.00 47.93 ? 676 HOH B O 1 HETATM 5444 O O . HOH H 4 . ? 46.868 99.914 82.707 1.00 37.68 ? 677 HOH B O 1 HETATM 5445 O O . HOH H 4 . ? 42.707 97.269 89.044 1.00 45.26 ? 678 HOH B O 1 HETATM 5446 O O . HOH H 4 . ? 68.057 81.994 86.527 1.00 39.00 ? 679 HOH B O 1 HETATM 5447 O O . HOH H 4 . ? 43.774 102.361 64.309 1.00 48.96 ? 680 HOH B O 1 HETATM 5448 O O . HOH H 4 . ? 52.333 67.218 76.927 1.00 57.48 ? 681 HOH B O 1 HETATM 5449 O O . HOH H 4 . ? 37.160 94.323 50.791 1.00 48.19 ? 682 HOH B O 1 HETATM 5450 O O . HOH H 4 . ? 48.676 86.277 52.170 1.00 45.54 ? 683 HOH B O 1 HETATM 5451 O O . HOH H 4 . ? 58.027 89.398 90.164 1.00 63.98 ? 684 HOH B O 1 HETATM 5452 O O . HOH H 4 . ? 66.541 70.388 83.695 1.00 47.47 ? 685 HOH B O 1 HETATM 5453 O O . HOH H 4 . ? 37.713 103.534 75.975 1.00 57.98 ? 686 HOH B O 1 HETATM 5454 O O . HOH H 4 . ? 58.518 94.378 81.799 1.00 38.59 ? 687 HOH B O 1 HETATM 5455 O O . HOH H 4 . ? 64.629 93.362 85.230 1.00 65.44 ? 688 HOH B O 1 HETATM 5456 O O . HOH H 4 . ? 27.524 96.334 67.333 1.00 53.64 ? 689 HOH B O 1 HETATM 5457 O O . HOH H 4 . ? 54.782 70.266 74.218 1.00 46.23 ? 690 HOH B O 1 HETATM 5458 O O . HOH H 4 . ? 36.123 74.284 84.136 1.00 64.04 ? 691 HOH B O 1 HETATM 5459 O O . HOH H 4 . ? 31.012 73.367 80.080 1.00 52.94 ? 692 HOH B O 1 HETATM 5460 O O . HOH H 4 . ? 48.633 73.929 91.497 1.00 50.73 ? 693 HOH B O 1 HETATM 5461 O O . HOH H 4 . ? 52.621 68.236 84.699 1.00 56.40 ? 694 HOH B O 1 HETATM 5462 O O . HOH H 4 . ? 48.737 98.172 75.072 1.00 36.08 ? 695 HOH B O 1 HETATM 5463 O O . HOH H 4 . ? 50.980 96.630 90.789 1.00 48.13 ? 696 HOH B O 1 HETATM 5464 O O . HOH H 4 . ? 54.428 94.711 86.691 1.00 40.93 ? 697 HOH B O 1 HETATM 5465 O O . HOH H 4 . ? 27.294 84.558 70.938 1.00 49.44 ? 698 HOH B O 1 HETATM 5466 O O . HOH H 4 . ? 43.730 75.975 61.003 1.00 49.02 ? 699 HOH B O 1 HETATM 5467 O O . HOH H 4 . ? 50.266 79.439 56.695 1.00 46.80 ? 700 HOH B O 1 HETATM 5468 O O . HOH H 4 . ? 62.758 80.237 77.392 1.00 40.57 ? 701 HOH B O 1 HETATM 5469 O O . HOH H 4 . ? 39.713 71.399 78.981 1.00 46.28 ? 702 HOH B O 1 HETATM 5470 O O . HOH H 4 . ? 38.348 70.247 83.870 1.00 53.87 ? 703 HOH B O 1 HETATM 5471 O O . HOH H 4 . ? 63.438 97.688 63.869 1.00 54.61 ? 704 HOH B O 1 HETATM 5472 O O . HOH H 4 . ? 63.299 92.756 75.994 1.00 52.72 ? 705 HOH B O 1 HETATM 5473 O O . HOH H 4 . ? 67.779 91.544 86.537 1.00 59.76 ? 706 HOH B O 1 HETATM 5474 O O . HOH H 4 . ? 68.322 76.523 89.515 1.00 52.76 ? 707 HOH B O 1 HETATM 5475 O O . HOH H 4 . ? 64.387 81.935 92.765 1.00 65.70 ? 708 HOH B O 1 HETATM 5476 O O . HOH H 4 . ? 56.980 87.235 64.374 1.00 46.04 ? 709 HOH B O 1 HETATM 5477 O O . HOH H 4 . ? 57.702 96.314 45.663 1.00 50.43 ? 710 HOH B O 1 HETATM 5478 O O . HOH H 4 . ? 52.908 95.970 70.811 1.00 47.26 ? 711 HOH B O 1 HETATM 5479 O O . HOH H 4 . ? 51.862 98.874 70.317 1.00 52.93 ? 712 HOH B O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 LEU 1 67 ? ? ? A . n A 1 2 THR 2 68 68 THR THR A . n A 1 3 LEU 3 69 69 LEU LEU A . n A 1 4 GLY 4 70 70 GLY GLY A . n A 1 5 ASN 5 71 71 ASN ASN A . n A 1 6 THR 6 72 72 THR THR A . n A 1 7 THR 7 73 73 THR THR A . n A 1 8 SER 8 74 74 SER SER A . n A 1 9 SER 9 75 75 SER SER A . n A 1 10 VAL 10 76 76 VAL VAL A . n A 1 11 ILE 11 77 77 ILE ILE A . n A 1 12 LEU 12 78 78 LEU LEU A . n A 1 13 THR 13 79 79 THR THR A . n A 1 14 ASN 14 80 80 ASN ASN A . n A 1 15 TYR 15 81 81 TYR TYR A . n A 1 16 MET 16 82 82 MET MET A . n A 1 17 ASP 17 83 83 ASP ASP A . n A 1 18 THR 18 84 84 THR THR A . n A 1 19 GLN 19 85 85 GLN GLN A . n A 1 20 TYR 20 86 86 TYR TYR A . n A 1 21 TYR 21 87 87 TYR TYR A . n A 1 22 GLY 22 88 88 GLY GLY A . n A 1 23 GLU 23 89 89 GLU GLU A . n A 1 24 ILE 24 90 90 ILE ILE A . n A 1 25 GLY 25 91 91 GLY GLY A . n A 1 26 ILE 26 92 92 ILE ILE A . n A 1 27 GLY 27 93 93 GLY GLY A . n A 1 28 THR 28 94 94 THR THR A . n A 1 29 PRO 29 95 95 PRO PRO A . n A 1 30 PRO 30 96 96 PRO PRO A . n A 1 31 GLN 31 97 97 GLN GLN A . n A 1 32 THR 32 98 98 THR THR A . n A 1 33 PHE 33 99 99 PHE PHE A . n A 1 34 LYS 34 100 100 LYS LYS A . n A 1 35 VAL 35 101 101 VAL VAL A . n A 1 36 VAL 36 102 102 VAL VAL A . n A 1 37 PHE 37 103 103 PHE PHE A . n A 1 38 ASP 38 104 104 ASP ASP A . n A 1 39 THR 39 105 105 THR THR A . n A 1 40 GLY 40 106 106 GLY GLY A . n A 1 41 SER 41 107 107 SER SER A . n A 1 42 SER 42 108 108 SER SER A . n A 1 43 ASN 43 109 109 ASN ASN A . n A 1 44 VAL 44 110 110 VAL VAL A . n A 1 45 TRP 45 111 111 TRP TRP A . n A 1 46 VAL 46 112 112 VAL VAL A . n A 1 47 PRO 47 113 113 PRO PRO A . n A 1 48 SER 48 114 114 SER SER A . n A 1 49 SER 49 115 115 SER SER A . n A 1 50 LYS 50 116 116 LYS LYS A . n A 1 51 CYS 51 117 117 CYS CYS A . n A 1 52 SER 52 118 118 SER SER A . n A 1 53 ARG 53 119 119 ARG ARG A . n A 1 54 LEU 54 120 120 LEU LEU A . n A 1 55 TYR 55 121 121 TYR TYR A . n A 1 56 THR 56 122 122 THR THR A . n A 1 57 ALA 57 123 123 ALA ALA A . n A 1 58 CYS 58 124 124 CYS CYS A . n A 1 59 VAL 59 125 125 VAL VAL A . n A 1 60 TYR 60 126 126 TYR TYR A . n A 1 61 HIS 61 127 127 HIS HIS A . n A 1 62 LYS 62 128 128 LYS LYS A . n A 1 63 LEU 63 129 129 LEU LEU A . n A 1 64 PHE 64 130 130 PHE PHE A . n A 1 65 ASP 65 131 131 ASP ASP A . n A 1 66 ALA 66 132 132 ALA ALA A . n A 1 67 SER 67 133 133 SER SER A . n A 1 68 ASP 68 134 134 ASP ASP A . n A 1 69 SER 69 135 135 SER SER A . n A 1 70 SER 70 136 136 SER SER A . n A 1 71 SER 71 137 137 SER SER A . n A 1 72 TYR 72 138 138 TYR TYR A . n A 1 73 LYS 73 139 139 LYS LYS A . n A 1 74 HIS 74 140 140 HIS HIS A . n A 1 75 ASN 75 141 141 ASN ASN A . n A 1 76 GLY 76 142 142 GLY GLY A . n A 1 77 THR 77 143 143 THR THR A . n A 1 78 GLU 78 144 144 GLU GLU A . n A 1 79 LEU 79 145 145 LEU LEU A . n A 1 80 THR 80 146 146 THR THR A . n A 1 81 LEU 81 147 147 LEU LEU A . n A 1 82 ARG 82 148 148 ARG ARG A . n A 1 83 TYR 83 149 149 TYR TYR A . n A 1 84 SER 84 150 150 SER SER A . n A 1 85 THR 85 151 151 THR THR A . n A 1 86 GLY 86 152 152 GLY GLY A . n A 1 87 THR 87 153 153 THR THR A . n A 1 88 VAL 88 154 154 VAL VAL A . n A 1 89 SER 89 155 155 SER SER A . n A 1 90 GLY 90 156 156 GLY GLY A . n A 1 91 PHE 91 157 157 PHE PHE A . n A 1 92 LEU 92 158 158 LEU LEU A . n A 1 93 SER 93 159 159 SER SER A . n A 1 94 GLN 94 160 160 GLN GLN A . n A 1 95 ASP 95 161 161 ASP ASP A . n A 1 96 ILE 96 162 162 ILE ILE A . n A 1 97 ILE 97 163 163 ILE ILE A . n A 1 98 THR 98 164 164 THR THR A . n A 1 99 VAL 99 165 165 VAL VAL A . n A 1 100 GLY 100 166 166 GLY GLY A . n A 1 101 GLY 101 167 167 GLY GLY A . n A 1 102 ILE 102 168 168 ILE ILE A . n A 1 103 THR 103 169 169 THR THR A . n A 1 104 VAL 104 170 170 VAL VAL A . n A 1 105 THR 105 171 171 THR THR A . n A 1 106 GLN 106 172 172 GLN GLN A . n A 1 107 MET 107 173 173 MET MET A . n A 1 108 PHE 108 174 174 PHE PHE A . n A 1 109 GLY 109 175 175 GLY GLY A . n A 1 110 GLU 110 176 176 GLU GLU A . n A 1 111 VAL 111 177 177 VAL VAL A . n A 1 112 THR 112 178 178 THR THR A . n A 1 113 GLU 113 179 179 GLU GLU A . n A 1 114 MET 114 180 180 MET MET A . n A 1 115 PRO 115 181 181 PRO PRO A . n A 1 116 ALA 116 182 182 ALA ALA A . n A 1 117 LEU 117 183 183 LEU LEU A . n A 1 118 PRO 118 184 184 PRO PRO A . n A 1 119 PHE 119 185 185 PHE PHE A . n A 1 120 MET 120 186 186 MET MET A . n A 1 121 LEU 121 187 187 LEU LEU A . n A 1 122 ALA 122 188 188 ALA ALA A . n A 1 123 GLU 123 189 189 GLU GLU A . n A 1 124 PHE 124 190 190 PHE PHE A . n A 1 125 ASP 125 191 191 ASP ASP A . n A 1 126 GLY 126 192 192 GLY GLY A . n A 1 127 VAL 127 193 193 VAL VAL A . n A 1 128 VAL 128 194 194 VAL VAL A . n A 1 129 GLY 129 195 195 GLY GLY A . n A 1 130 MET 130 196 196 MET MET A . n A 1 131 GLY 131 197 197 GLY GLY A . n A 1 132 PHE 132 198 198 PHE PHE A . n A 1 133 ILE 133 199 199 ILE ILE A . n A 1 134 GLU 134 200 200 GLU GLU A . n A 1 135 GLN 135 201 201 GLN GLN A . n A 1 136 ALA 136 202 202 ALA ALA A . n A 1 137 ILE 137 203 203 ILE ILE A . n A 1 138 GLY 138 204 204 GLY GLY A . n A 1 139 ARG 139 205 205 ARG ARG A . n A 1 140 VAL 140 206 206 VAL VAL A . n A 1 141 THR 141 207 207 THR THR A . n A 1 142 PRO 142 208 208 PRO PRO A . n A 1 143 ILE 143 209 209 ILE ILE A . n A 1 144 PHE 144 210 210 PHE PHE A . n A 1 145 ASP 145 211 211 ASP ASP A . n A 1 146 ASN 146 212 212 ASN ASN A . n A 1 147 ILE 147 213 213 ILE ILE A . n A 1 148 ILE 148 214 214 ILE ILE A . n A 1 149 SER 149 215 215 SER SER A . n A 1 150 GLN 150 216 216 GLN GLN A . n A 1 151 GLY 151 217 217 GLY GLY A . n A 1 152 VAL 152 218 218 VAL VAL A . n A 1 153 LEU 153 219 219 LEU LEU A . n A 1 154 LYS 154 220 220 LYS LYS A . n A 1 155 GLU 155 221 221 GLU GLU A . n A 1 156 ASP 156 222 222 ASP ASP A . n A 1 157 VAL 157 223 223 VAL VAL A . n A 1 158 PHE 158 224 224 PHE PHE A . n A 1 159 SER 159 225 225 SER SER A . n A 1 160 PHE 160 226 226 PHE PHE A . n A 1 161 TYR 161 227 227 TYR TYR A . n A 1 162 TYR 162 228 228 TYR TYR A . n A 1 163 ASN 163 229 229 ASN ASN A . n A 1 164 ARG 164 230 230 ARG ARG A . n A 1 165 ASP 165 231 231 ASP ASP A . n A 1 166 SER 166 232 232 SER SER A . n A 1 167 GLU 167 233 233 GLU GLU A . n A 1 168 ASN 168 234 234 ASN ASN A . n A 1 169 SER 169 235 235 SER SER A . n A 1 170 GLN 170 236 236 GLN GLN A . n A 1 171 SER 171 237 237 SER SER A . n A 1 172 LEU 172 238 238 LEU LEU A . n A 1 173 GLY 173 239 239 GLY GLY A . n A 1 174 GLY 174 240 240 GLY GLY A . n A 1 175 GLN 175 241 241 GLN GLN A . n A 1 176 ILE 176 242 242 ILE ILE A . n A 1 177 VAL 177 243 243 VAL VAL A . n A 1 178 LEU 178 244 244 LEU LEU A . n A 1 179 GLY 179 245 245 GLY GLY A . n A 1 180 GLY 180 246 246 GLY GLY A . n A 1 181 SER 181 247 247 SER SER A . n A 1 182 ASP 182 248 248 ASP ASP A . n A 1 183 PRO 183 249 249 PRO PRO A . n A 1 184 GLN 184 250 250 GLN GLN A . n A 1 185 HIS 185 251 251 HIS HIS A . n A 1 186 TYR 186 252 252 TYR TYR A . n A 1 187 GLU 187 253 253 GLU GLU A . n A 1 188 GLY 188 254 254 GLY GLY A . n A 1 189 ASN 189 255 255 ASN ASN A . n A 1 190 PHE 190 256 256 PHE PHE A . n A 1 191 HIS 191 257 257 HIS HIS A . n A 1 192 TYR 192 258 258 TYR TYR A . n A 1 193 ILE 193 259 259 ILE ILE A . n A 1 194 ASN 194 260 260 ASN ASN A . n A 1 195 LEU 195 261 261 LEU LEU A . n A 1 196 ILE 196 262 262 ILE ILE A . n A 1 197 LYS 197 263 263 LYS LYS A . n A 1 198 THR 198 264 264 THR THR A . n A 1 199 GLY 199 265 265 GLY GLY A . n A 1 200 VAL 200 266 266 VAL VAL A . n A 1 201 TRP 201 267 267 TRP TRP A . n A 1 202 GLN 202 268 268 GLN GLN A . n A 1 203 ILE 203 269 269 ILE ILE A . n A 1 204 GLN 204 270 270 GLN GLN A . n A 1 205 MET 205 271 271 MET MET A . n A 1 206 LYS 206 272 272 LYS LYS A . n A 1 207 GLY 207 273 273 GLY GLY A . n A 1 208 VAL 208 274 274 VAL VAL A . n A 1 209 SER 209 275 275 SER SER A . n A 1 210 VAL 210 276 276 VAL VAL A . n A 1 211 GLY 211 277 277 GLY GLY A . n A 1 212 SER 212 278 278 SER SER A . n A 1 213 SER 213 279 279 SER SER A . n A 1 214 THR 214 280 280 THR THR A . n A 1 215 LEU 215 281 281 LEU LEU A . n A 1 216 LEU 216 282 282 LEU LEU A . n A 1 217 CYS 217 283 283 CYS CYS A . n A 1 218 GLU 218 284 284 GLU GLU A . n A 1 219 ASP 219 285 285 ASP ASP A . n A 1 220 GLY 220 286 286 GLY GLY A . n A 1 221 CYS 221 287 287 CYS CYS A . n A 1 222 LEU 222 288 288 LEU LEU A . n A 1 223 ALA 223 289 289 ALA ALA A . n A 1 224 LEU 224 290 290 LEU LEU A . n A 1 225 VAL 225 291 291 VAL VAL A . n A 1 226 ASP 226 292 292 ASP ASP A . n A 1 227 THR 227 293 293 THR THR A . n A 1 228 GLY 228 294 294 GLY GLY A . n A 1 229 ALA 229 295 295 ALA ALA A . n A 1 230 SER 230 296 296 SER SER A . n A 1 231 TYR 231 297 297 TYR TYR A . n A 1 232 ILE 232 298 298 ILE ILE A . n A 1 233 SER 233 299 299 SER SER A . n A 1 234 GLY 234 300 300 GLY GLY A . n A 1 235 SER 235 301 301 SER SER A . n A 1 236 THR 236 302 302 THR THR A . n A 1 237 SER 237 303 303 SER SER A . n A 1 238 SER 238 304 304 SER SER A . n A 1 239 ILE 239 305 305 ILE ILE A . n A 1 240 GLU 240 306 306 GLU GLU A . n A 1 241 LYS 241 307 307 LYS LYS A . n A 1 242 LEU 242 308 308 LEU LEU A . n A 1 243 MET 243 309 309 MET MET A . n A 1 244 GLU 244 310 310 GLU GLU A . n A 1 245 ALA 245 311 311 ALA ALA A . n A 1 246 LEU 246 312 312 LEU LEU A . n A 1 247 GLY 247 313 313 GLY GLY A . n A 1 248 ALA 248 314 314 ALA ALA A . n A 1 249 LYS 249 315 315 LYS ALA A . n A 1 250 LYS 250 316 316 LYS LYS A . n A 1 251 ARG 251 317 317 ARG ARG A . n A 1 252 LEU 252 318 318 LEU LEU A . n A 1 253 PHE 253 319 319 PHE PHE A . n A 1 254 ASP 254 320 320 ASP ASP A . n A 1 255 TYR 255 321 321 TYR TYR A . n A 1 256 VAL 256 322 322 VAL VAL A . n A 1 257 VAL 257 323 323 VAL VAL A . n A 1 258 LYS 258 324 324 LYS LYS A . n A 1 259 CYS 259 325 325 CYS CYS A . n A 1 260 ASN 260 326 326 ASN ASN A . n A 1 261 GLU 261 327 327 GLU GLU A . n A 1 262 GLY 262 328 328 GLY GLY A . n A 1 263 PRO 263 329 329 PRO PRO A . n A 1 264 THR 264 330 330 THR THR A . n A 1 265 LEU 265 331 331 LEU LEU A . n A 1 266 PRO 266 332 332 PRO PRO A . n A 1 267 ASP 267 333 333 ASP ASP A . n A 1 268 ILE 268 334 334 ILE ILE A . n A 1 269 SER 269 335 335 SER SER A . n A 1 270 PHE 270 336 336 PHE PHE A . n A 1 271 HIS 271 337 337 HIS HIS A . n A 1 272 LEU 272 338 338 LEU LEU A . n A 1 273 GLY 273 339 339 GLY GLY A . n A 1 274 GLY 274 340 340 GLY GLY A . n A 1 275 LYS 275 341 341 LYS LYS A . n A 1 276 GLU 276 342 342 GLU GLU A . n A 1 277 TYR 277 343 343 TYR TYR A . n A 1 278 THR 278 344 344 THR THR A . n A 1 279 LEU 279 345 345 LEU LEU A . n A 1 280 THR 280 346 346 THR THR A . n A 1 281 SER 281 347 347 SER SER A . n A 1 282 ALA 282 348 348 ALA ALA A . n A 1 283 ASP 283 349 349 ASP ASP A . n A 1 284 TYR 284 350 350 TYR TYR A . n A 1 285 VAL 285 351 351 VAL VAL A . n A 1 286 PHE 286 352 352 PHE PHE A . n A 1 287 GLN 287 353 353 GLN GLN A . n A 1 288 GLU 288 354 354 GLU GLU A . n A 1 289 SER 289 355 355 SER SER A . n A 1 290 TYR 290 356 356 TYR TYR A . n A 1 291 SER 291 357 357 SER SER A . n A 1 292 SER 292 358 358 SER SER A . n A 1 293 LYS 293 359 359 LYS LYS A . n A 1 294 LYS 294 360 360 LYS LYS A . n A 1 295 LEU 295 361 361 LEU LEU A . n A 1 296 CYS 296 362 362 CYS CYS A . n A 1 297 THR 297 363 363 THR THR A . n A 1 298 LEU 298 364 364 LEU LEU A . n A 1 299 ALA 299 365 365 ALA ALA A . n A 1 300 ILE 300 366 366 ILE ILE A . n A 1 301 HIS 301 367 367 HIS HIS A . n A 1 302 ALA 302 368 368 ALA ALA A . n A 1 303 MET 303 369 369 MET MET A . n A 1 304 ASP 304 370 370 ASP ASP A . n A 1 305 ILE 305 371 371 ILE ILE A . n A 1 306 PRO 306 372 372 PRO PRO A . n A 1 307 PRO 307 373 373 PRO PRO A . n A 1 308 PRO 308 374 374 PRO PRO A . n A 1 309 THR 309 375 375 THR THR A . n A 1 310 GLY 310 376 376 GLY GLY A . n A 1 311 PRO 311 377 377 PRO PRO A . n A 1 312 THR 312 378 378 THR THR A . n A 1 313 TRP 313 379 379 TRP TRP A . n A 1 314 ALA 314 380 380 ALA ALA A . n A 1 315 LEU 315 381 381 LEU LEU A . n A 1 316 GLY 316 382 382 GLY GLY A . n A 1 317 ALA 317 383 383 ALA ALA A . n A 1 318 THR 318 384 384 THR THR A . n A 1 319 PHE 319 385 385 PHE PHE A . n A 1 320 ILE 320 386 386 ILE ILE A . n A 1 321 ARG 321 387 387 ARG ARG A . n A 1 322 LYS 322 388 388 LYS LYS A . n A 1 323 PHE 323 389 389 PHE PHE A . n A 1 324 TYR 324 390 390 TYR TYR A . n A 1 325 THR 325 391 391 THR THR A . n A 1 326 GLU 326 392 392 GLU GLU A . n A 1 327 PHE 327 393 393 PHE PHE A . n A 1 328 ASP 328 394 394 ASP ASP A . n A 1 329 ARG 329 395 395 ARG ARG A . n A 1 330 ARG 330 396 396 ARG ARG A . n A 1 331 ASN 331 397 397 ASN ASN A . n A 1 332 ASN 332 398 398 ASN ASN A . n A 1 333 ARG 333 399 399 ARG ARG A . n A 1 334 ILE 334 400 400 ILE ILE A . n A 1 335 GLY 335 401 401 GLY GLY A . n A 1 336 PHE 336 402 402 PHE PHE A . n A 1 337 ALA 337 403 403 ALA ALA A . n A 1 338 LEU 338 404 404 LEU LEU A . n A 1 339 ALA 339 405 405 ALA ALA A . n A 1 340 ARG 340 406 406 ARG ARG A . n B 1 1 LEU 1 67 67 LEU LEU B . n B 1 2 THR 2 68 68 THR THR B . n B 1 3 LEU 3 69 69 LEU LEU B . n B 1 4 GLY 4 70 70 GLY GLY B . n B 1 5 ASN 5 71 71 ASN ASN B . n B 1 6 THR 6 72 72 THR THR B . n B 1 7 THR 7 73 73 THR THR B . n B 1 8 SER 8 74 74 SER SER B . n B 1 9 SER 9 75 75 SER SER B . n B 1 10 VAL 10 76 76 VAL VAL B . n B 1 11 ILE 11 77 77 ILE ILE B . n B 1 12 LEU 12 78 78 LEU LEU B . n B 1 13 THR 13 79 79 THR THR B . n B 1 14 ASN 14 80 80 ASN ASN B . n B 1 15 TYR 15 81 81 TYR TYR B . n B 1 16 MET 16 82 82 MET MET B . n B 1 17 ASP 17 83 83 ASP ASP B . n B 1 18 THR 18 84 84 THR THR B . n B 1 19 GLN 19 85 85 GLN GLN B . n B 1 20 TYR 20 86 86 TYR TYR B . n B 1 21 TYR 21 87 87 TYR TYR B . n B 1 22 GLY 22 88 88 GLY GLY B . n B 1 23 GLU 23 89 89 GLU GLU B . n B 1 24 ILE 24 90 90 ILE ILE B . n B 1 25 GLY 25 91 91 GLY GLY B . n B 1 26 ILE 26 92 92 ILE ILE B . n B 1 27 GLY 27 93 93 GLY GLY B . n B 1 28 THR 28 94 94 THR THR B . n B 1 29 PRO 29 95 95 PRO PRO B . n B 1 30 PRO 30 96 96 PRO PRO B . n B 1 31 GLN 31 97 97 GLN GLN B . n B 1 32 THR 32 98 98 THR THR B . n B 1 33 PHE 33 99 99 PHE PHE B . n B 1 34 LYS 34 100 100 LYS LYS B . n B 1 35 VAL 35 101 101 VAL VAL B . n B 1 36 VAL 36 102 102 VAL VAL B . n B 1 37 PHE 37 103 103 PHE PHE B . n B 1 38 ASP 38 104 104 ASP ASP B . n B 1 39 THR 39 105 105 THR THR B . n B 1 40 GLY 40 106 106 GLY GLY B . n B 1 41 SER 41 107 107 SER SER B . n B 1 42 SER 42 108 108 SER SER B . n B 1 43 ASN 43 109 109 ASN ASN B . n B 1 44 VAL 44 110 110 VAL VAL B . n B 1 45 TRP 45 111 111 TRP TRP B . n B 1 46 VAL 46 112 112 VAL VAL B . n B 1 47 PRO 47 113 113 PRO PRO B . n B 1 48 SER 48 114 114 SER SER B . n B 1 49 SER 49 115 115 SER SER B . n B 1 50 LYS 50 116 116 LYS LYS B . n B 1 51 CYS 51 117 117 CYS CYS B . n B 1 52 SER 52 118 118 SER SER B . n B 1 53 ARG 53 119 119 ARG ARG B . n B 1 54 LEU 54 120 120 LEU LEU B . n B 1 55 TYR 55 121 121 TYR TYR B . n B 1 56 THR 56 122 122 THR THR B . n B 1 57 ALA 57 123 123 ALA ALA B . n B 1 58 CYS 58 124 124 CYS CYS B . n B 1 59 VAL 59 125 125 VAL VAL B . n B 1 60 TYR 60 126 126 TYR ALA B . n B 1 61 HIS 61 127 127 HIS HIS B . n B 1 62 LYS 62 128 128 LYS LYS B . n B 1 63 LEU 63 129 129 LEU LEU B . n B 1 64 PHE 64 130 130 PHE PHE B . n B 1 65 ASP 65 131 131 ASP ASP B . n B 1 66 ALA 66 132 132 ALA ALA B . n B 1 67 SER 67 133 133 SER SER B . n B 1 68 ASP 68 134 134 ASP ASP B . n B 1 69 SER 69 135 135 SER SER B . n B 1 70 SER 70 136 136 SER SER B . n B 1 71 SER 71 137 137 SER SER B . n B 1 72 TYR 72 138 138 TYR TYR B . n B 1 73 LYS 73 139 139 LYS LYS B . n B 1 74 HIS 74 140 140 HIS HIS B . n B 1 75 ASN 75 141 141 ASN ASN B . n B 1 76 GLY 76 142 142 GLY GLY B . n B 1 77 THR 77 143 143 THR THR B . n B 1 78 GLU 78 144 144 GLU GLU B . n B 1 79 LEU 79 145 145 LEU LEU B . n B 1 80 THR 80 146 146 THR THR B . n B 1 81 LEU 81 147 147 LEU LEU B . n B 1 82 ARG 82 148 148 ARG ARG B . n B 1 83 TYR 83 149 149 TYR TYR B . n B 1 84 SER 84 150 150 SER SER B . n B 1 85 THR 85 151 151 THR THR B . n B 1 86 GLY 86 152 152 GLY GLY B . n B 1 87 THR 87 153 153 THR THR B . n B 1 88 VAL 88 154 154 VAL VAL B . n B 1 89 SER 89 155 155 SER SER B . n B 1 90 GLY 90 156 156 GLY GLY B . n B 1 91 PHE 91 157 157 PHE PHE B . n B 1 92 LEU 92 158 158 LEU LEU B . n B 1 93 SER 93 159 159 SER SER B . n B 1 94 GLN 94 160 160 GLN GLN B . n B 1 95 ASP 95 161 161 ASP ASP B . n B 1 96 ILE 96 162 162 ILE ILE B . n B 1 97 ILE 97 163 163 ILE ILE B . n B 1 98 THR 98 164 164 THR THR B . n B 1 99 VAL 99 165 165 VAL VAL B . n B 1 100 GLY 100 166 166 GLY GLY B . n B 1 101 GLY 101 167 167 GLY GLY B . n B 1 102 ILE 102 168 168 ILE ILE B . n B 1 103 THR 103 169 169 THR THR B . n B 1 104 VAL 104 170 170 VAL VAL B . n B 1 105 THR 105 171 171 THR THR B . n B 1 106 GLN 106 172 172 GLN GLN B . n B 1 107 MET 107 173 173 MET MET B . n B 1 108 PHE 108 174 174 PHE PHE B . n B 1 109 GLY 109 175 175 GLY GLY B . n B 1 110 GLU 110 176 176 GLU GLU B . n B 1 111 VAL 111 177 177 VAL VAL B . n B 1 112 THR 112 178 178 THR THR B . n B 1 113 GLU 113 179 179 GLU GLU B . n B 1 114 MET 114 180 180 MET MET B . n B 1 115 PRO 115 181 181 PRO PRO B . n B 1 116 ALA 116 182 182 ALA ALA B . n B 1 117 LEU 117 183 183 LEU LEU B . n B 1 118 PRO 118 184 184 PRO PRO B . n B 1 119 PHE 119 185 185 PHE PHE B . n B 1 120 MET 120 186 186 MET MET B . n B 1 121 LEU 121 187 187 LEU LEU B . n B 1 122 ALA 122 188 188 ALA ALA B . n B 1 123 GLU 123 189 189 GLU GLU B . n B 1 124 PHE 124 190 190 PHE PHE B . n B 1 125 ASP 125 191 191 ASP ASP B . n B 1 126 GLY 126 192 192 GLY GLY B . n B 1 127 VAL 127 193 193 VAL VAL B . n B 1 128 VAL 128 194 194 VAL VAL B . n B 1 129 GLY 129 195 195 GLY GLY B . n B 1 130 MET 130 196 196 MET MET B . n B 1 131 GLY 131 197 197 GLY GLY B . n B 1 132 PHE 132 198 198 PHE PHE B . n B 1 133 ILE 133 199 199 ILE ILE B . n B 1 134 GLU 134 200 200 GLU GLU B . n B 1 135 GLN 135 201 201 GLN GLN B . n B 1 136 ALA 136 202 202 ALA ALA B . n B 1 137 ILE 137 203 203 ILE ILE B . n B 1 138 GLY 138 204 204 GLY GLY B . n B 1 139 ARG 139 205 205 ARG ARG B . n B 1 140 VAL 140 206 206 VAL VAL B . n B 1 141 THR 141 207 207 THR THR B . n B 1 142 PRO 142 208 208 PRO PRO B . n B 1 143 ILE 143 209 209 ILE ILE B . n B 1 144 PHE 144 210 210 PHE PHE B . n B 1 145 ASP 145 211 211 ASP ASP B . n B 1 146 ASN 146 212 212 ASN ASN B . n B 1 147 ILE 147 213 213 ILE ILE B . n B 1 148 ILE 148 214 214 ILE ILE B . n B 1 149 SER 149 215 215 SER SER B . n B 1 150 GLN 150 216 216 GLN GLN B . n B 1 151 GLY 151 217 217 GLY GLY B . n B 1 152 VAL 152 218 218 VAL VAL B . n B 1 153 LEU 153 219 219 LEU LEU B . n B 1 154 LYS 154 220 220 LYS LYS B . n B 1 155 GLU 155 221 221 GLU GLU B . n B 1 156 ASP 156 222 222 ASP ASP B . n B 1 157 VAL 157 223 223 VAL VAL B . n B 1 158 PHE 158 224 224 PHE PHE B . n B 1 159 SER 159 225 225 SER SER B . n B 1 160 PHE 160 226 226 PHE PHE B . n B 1 161 TYR 161 227 227 TYR TYR B . n B 1 162 TYR 162 228 228 TYR TYR B . n B 1 163 ASN 163 229 229 ASN ASN B . n B 1 164 ARG 164 230 230 ARG ARG B . n B 1 165 ASP 165 231 231 ASP ASP B . n B 1 166 SER 166 232 232 SER SER B . n B 1 167 GLU 167 233 ? ? ? B . n B 1 168 ASN 168 234 ? ? ? B . n B 1 169 SER 169 235 235 SER SER B . n B 1 170 GLN 170 236 236 GLN GLN B . n B 1 171 SER 171 237 237 SER SER B . n B 1 172 LEU 172 238 238 LEU LEU B . n B 1 173 GLY 173 239 239 GLY GLY B . n B 1 174 GLY 174 240 240 GLY GLY B . n B 1 175 GLN 175 241 241 GLN GLN B . n B 1 176 ILE 176 242 242 ILE ILE B . n B 1 177 VAL 177 243 243 VAL VAL B . n B 1 178 LEU 178 244 244 LEU LEU B . n B 1 179 GLY 179 245 245 GLY GLY B . n B 1 180 GLY 180 246 246 GLY GLY B . n B 1 181 SER 181 247 247 SER SER B . n B 1 182 ASP 182 248 248 ASP ASP B . n B 1 183 PRO 183 249 249 PRO PRO B . n B 1 184 GLN 184 250 250 GLN GLN B . n B 1 185 HIS 185 251 251 HIS HIS B . n B 1 186 TYR 186 252 252 TYR TYR B . n B 1 187 GLU 187 253 253 GLU GLU B . n B 1 188 GLY 188 254 254 GLY GLY B . n B 1 189 ASN 189 255 255 ASN ASN B . n B 1 190 PHE 190 256 256 PHE PHE B . n B 1 191 HIS 191 257 257 HIS HIS B . n B 1 192 TYR 192 258 258 TYR TYR B . n B 1 193 ILE 193 259 259 ILE ILE B . n B 1 194 ASN 194 260 260 ASN ASN B . n B 1 195 LEU 195 261 261 LEU LEU B . n B 1 196 ILE 196 262 262 ILE ILE B . n B 1 197 LYS 197 263 263 LYS LYS B . n B 1 198 THR 198 264 264 THR THR B . n B 1 199 GLY 199 265 265 GLY GLY B . n B 1 200 VAL 200 266 266 VAL VAL B . n B 1 201 TRP 201 267 267 TRP TRP B . n B 1 202 GLN 202 268 268 GLN GLN B . n B 1 203 ILE 203 269 269 ILE ILE B . n B 1 204 GLN 204 270 270 GLN GLN B . n B 1 205 MET 205 271 271 MET MET B . n B 1 206 LYS 206 272 272 LYS LYS B . n B 1 207 GLY 207 273 273 GLY GLY B . n B 1 208 VAL 208 274 274 VAL VAL B . n B 1 209 SER 209 275 275 SER SER B . n B 1 210 VAL 210 276 276 VAL VAL B . n B 1 211 GLY 211 277 277 GLY GLY B . n B 1 212 SER 212 278 278 SER SER B . n B 1 213 SER 213 279 279 SER SER B . n B 1 214 THR 214 280 280 THR THR B . n B 1 215 LEU 215 281 281 LEU LEU B . n B 1 216 LEU 216 282 282 LEU LEU B . n B 1 217 CYS 217 283 283 CYS CYS B . n B 1 218 GLU 218 284 284 GLU GLU B . n B 1 219 ASP 219 285 285 ASP ASP B . n B 1 220 GLY 220 286 286 GLY GLY B . n B 1 221 CYS 221 287 287 CYS CYS B . n B 1 222 LEU 222 288 288 LEU LEU B . n B 1 223 ALA 223 289 289 ALA ALA B . n B 1 224 LEU 224 290 290 LEU LEU B . n B 1 225 VAL 225 291 291 VAL VAL B . n B 1 226 ASP 226 292 292 ASP ASP B . n B 1 227 THR 227 293 293 THR THR B . n B 1 228 GLY 228 294 294 GLY GLY B . n B 1 229 ALA 229 295 295 ALA ALA B . n B 1 230 SER 230 296 296 SER SER B . n B 1 231 TYR 231 297 297 TYR TYR B . n B 1 232 ILE 232 298 298 ILE ILE B . n B 1 233 SER 233 299 299 SER SER B . n B 1 234 GLY 234 300 300 GLY GLY B . n B 1 235 SER 235 301 301 SER SER B . n B 1 236 THR 236 302 302 THR THR B . n B 1 237 SER 237 303 303 SER SER B . n B 1 238 SER 238 304 304 SER SER B . n B 1 239 ILE 239 305 305 ILE ILE B . n B 1 240 GLU 240 306 306 GLU GLU B . n B 1 241 LYS 241 307 307 LYS LYS B . n B 1 242 LEU 242 308 308 LEU LEU B . n B 1 243 MET 243 309 309 MET MET B . n B 1 244 GLU 244 310 310 GLU GLU B . n B 1 245 ALA 245 311 311 ALA ALA B . n B 1 246 LEU 246 312 312 LEU LEU B . n B 1 247 GLY 247 313 313 GLY GLY B . n B 1 248 ALA 248 314 314 ALA ALA B . n B 1 249 LYS 249 315 315 LYS LYS B . n B 1 250 LYS 250 316 316 LYS LYS B . n B 1 251 ARG 251 317 317 ARG ARG B . n B 1 252 LEU 252 318 318 LEU LEU B . n B 1 253 PHE 253 319 319 PHE PHE B . n B 1 254 ASP 254 320 320 ASP ASP B . n B 1 255 TYR 255 321 321 TYR TYR B . n B 1 256 VAL 256 322 322 VAL VAL B . n B 1 257 VAL 257 323 323 VAL VAL B . n B 1 258 LYS 258 324 324 LYS LYS B . n B 1 259 CYS 259 325 325 CYS CYS B . n B 1 260 ASN 260 326 326 ASN ASN B . n B 1 261 GLU 261 327 327 GLU GLU B . n B 1 262 GLY 262 328 328 GLY GLY B . n B 1 263 PRO 263 329 329 PRO PRO B . n B 1 264 THR 264 330 330 THR THR B . n B 1 265 LEU 265 331 331 LEU LEU B . n B 1 266 PRO 266 332 332 PRO PRO B . n B 1 267 ASP 267 333 333 ASP ASP B . n B 1 268 ILE 268 334 334 ILE ILE B . n B 1 269 SER 269 335 335 SER SER B . n B 1 270 PHE 270 336 336 PHE PHE B . n B 1 271 HIS 271 337 337 HIS HIS B . n B 1 272 LEU 272 338 338 LEU LEU B . n B 1 273 GLY 273 339 339 GLY GLY B . n B 1 274 GLY 274 340 340 GLY GLY B . n B 1 275 LYS 275 341 341 LYS LYS B . n B 1 276 GLU 276 342 342 GLU GLU B . n B 1 277 TYR 277 343 343 TYR TYR B . n B 1 278 THR 278 344 344 THR THR B . n B 1 279 LEU 279 345 345 LEU LEU B . n B 1 280 THR 280 346 346 THR THR B . n B 1 281 SER 281 347 347 SER SER B . n B 1 282 ALA 282 348 348 ALA ALA B . n B 1 283 ASP 283 349 349 ASP ASP B . n B 1 284 TYR 284 350 350 TYR TYR B . n B 1 285 VAL 285 351 351 VAL VAL B . n B 1 286 PHE 286 352 352 PHE PHE B . n B 1 287 GLN 287 353 353 GLN GLN B . n B 1 288 GLU 288 354 354 GLU GLU B . n B 1 289 SER 289 355 355 SER SER B . n B 1 290 TYR 290 356 356 TYR TYR B . n B 1 291 SER 291 357 357 SER SER B . n B 1 292 SER 292 358 358 SER SER B . n B 1 293 LYS 293 359 359 LYS LYS B . n B 1 294 LYS 294 360 360 LYS LYS B . n B 1 295 LEU 295 361 361 LEU LEU B . n B 1 296 CYS 296 362 362 CYS CYS B . n B 1 297 THR 297 363 363 THR THR B . n B 1 298 LEU 298 364 364 LEU LEU B . n B 1 299 ALA 299 365 365 ALA ALA B . n B 1 300 ILE 300 366 366 ILE ILE B . n B 1 301 HIS 301 367 367 HIS HIS B . n B 1 302 ALA 302 368 368 ALA ALA B . n B 1 303 MET 303 369 369 MET MET B . n B 1 304 ASP 304 370 370 ASP ASP B . n B 1 305 ILE 305 371 371 ILE ILE B . n B 1 306 PRO 306 372 372 PRO PRO B . n B 1 307 PRO 307 373 373 PRO PRO B . n B 1 308 PRO 308 374 374 PRO PRO B . n B 1 309 THR 309 375 375 THR THR B . n B 1 310 GLY 310 376 376 GLY GLY B . n B 1 311 PRO 311 377 377 PRO PRO B . n B 1 312 THR 312 378 378 THR THR B . n B 1 313 TRP 313 379 379 TRP TRP B . n B 1 314 ALA 314 380 380 ALA ALA B . n B 1 315 LEU 315 381 381 LEU LEU B . n B 1 316 GLY 316 382 382 GLY GLY B . n B 1 317 ALA 317 383 383 ALA ALA B . n B 1 318 THR 318 384 384 THR THR B . n B 1 319 PHE 319 385 385 PHE PHE B . n B 1 320 ILE 320 386 386 ILE ILE B . n B 1 321 ARG 321 387 387 ARG ARG B . n B 1 322 LYS 322 388 388 LYS LYS B . n B 1 323 PHE 323 389 389 PHE PHE B . n B 1 324 TYR 324 390 390 TYR TYR B . n B 1 325 THR 325 391 391 THR THR B . n B 1 326 GLU 326 392 392 GLU GLU B . n B 1 327 PHE 327 393 393 PHE PHE B . n B 1 328 ASP 328 394 394 ASP ASP B . n B 1 329 ARG 329 395 395 ARG ARG B . n B 1 330 ARG 330 396 396 ARG ARG B . n B 1 331 ASN 331 397 397 ASN ASN B . n B 1 332 ASN 332 398 398 ASN ASN B . n B 1 333 ARG 333 399 399 ARG ARG B . n B 1 334 ILE 334 400 400 ILE ILE B . n B 1 335 GLY 335 401 401 GLY GLY B . n B 1 336 PHE 336 402 402 PHE PHE B . n B 1 337 ALA 337 403 403 ALA ALA B . n B 1 338 LEU 338 404 404 LEU LEU B . n B 1 339 ALA 339 405 405 ALA ALA B . n B 1 340 ARG 340 406 406 ARG ARG B . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code C 2 NAG 1 501 447 NAG NAG A . D 3 70X 1 502 1 70X 070 A . E 2 NAG 1 501 447 NAG NAG B . F 3 70X 1 502 2 70X 070 B . G 4 HOH 1 601 67 HOH HOH A . G 4 HOH 2 602 41 HOH HOH A . G 4 HOH 3 603 68 HOH HOH A . G 4 HOH 4 604 7 HOH HOH A . G 4 HOH 5 605 209 HOH HOH A . G 4 HOH 6 606 173 HOH HOH A . G 4 HOH 7 607 134 HOH HOH A . G 4 HOH 8 608 163 HOH HOH A . G 4 HOH 9 609 78 HOH HOH A . G 4 HOH 10 610 265 HOH HOH A . G 4 HOH 11 611 306 HOH HOH A . G 4 HOH 12 612 17 HOH HOH A . G 4 HOH 13 613 207 HOH HOH A . G 4 HOH 14 614 273 HOH HOH A . G 4 HOH 15 615 213 HOH HOH A . G 4 HOH 16 616 220 HOH HOH A . G 4 HOH 17 617 3 HOH HOH A . G 4 HOH 18 618 292 HOH HOH A . G 4 HOH 19 619 175 HOH HOH A . G 4 HOH 20 620 309 HOH HOH A . G 4 HOH 21 621 12 HOH HOH A . G 4 HOH 22 622 15 HOH HOH A . G 4 HOH 23 623 193 HOH HOH A . G 4 HOH 24 624 2 HOH HOH A . G 4 HOH 25 625 4 HOH HOH A . G 4 HOH 26 626 6 HOH HOH A . G 4 HOH 27 627 8 HOH HOH A . G 4 HOH 28 628 10 HOH HOH A . G 4 HOH 29 629 13 HOH HOH A . G 4 HOH 30 630 16 HOH HOH A . G 4 HOH 31 631 19 HOH HOH A . G 4 HOH 32 632 21 HOH HOH A . G 4 HOH 33 633 28 HOH HOH A . G 4 HOH 34 634 29 HOH HOH A . G 4 HOH 35 635 32 HOH HOH A . G 4 HOH 36 636 33 HOH HOH A . G 4 HOH 37 637 34 HOH HOH A . G 4 HOH 38 638 35 HOH HOH A . G 4 HOH 39 639 36 HOH HOH A . G 4 HOH 40 640 37 HOH HOH A . G 4 HOH 41 641 40 HOH HOH A . G 4 HOH 42 642 42 HOH HOH A . G 4 HOH 43 643 43 HOH HOH A . G 4 HOH 44 644 44 HOH HOH A . G 4 HOH 45 645 47 HOH HOH A . G 4 HOH 46 646 49 HOH HOH A . G 4 HOH 47 647 50 HOH HOH A . G 4 HOH 48 648 51 HOH HOH A . G 4 HOH 49 649 52 HOH HOH A . G 4 HOH 50 650 53 HOH HOH A . G 4 HOH 51 651 56 HOH HOH A . G 4 HOH 52 652 57 HOH HOH A . G 4 HOH 53 653 58 HOH HOH A . G 4 HOH 54 654 64 HOH HOH A . G 4 HOH 55 655 65 HOH HOH A . G 4 HOH 56 656 66 HOH HOH A . G 4 HOH 57 657 69 HOH HOH A . G 4 HOH 58 658 70 HOH HOH A . G 4 HOH 59 659 72 HOH HOH A . G 4 HOH 60 660 74 HOH HOH A . G 4 HOH 61 661 75 HOH HOH A . G 4 HOH 62 662 76 HOH HOH A . G 4 HOH 63 663 79 HOH HOH A . G 4 HOH 64 664 80 HOH HOH A . G 4 HOH 65 665 83 HOH HOH A . G 4 HOH 66 666 84 HOH HOH A . G 4 HOH 67 667 85 HOH HOH A . G 4 HOH 68 668 88 HOH HOH A . G 4 HOH 69 669 89 HOH HOH A . G 4 HOH 70 670 90 HOH HOH A . G 4 HOH 71 671 94 HOH HOH A . G 4 HOH 72 672 95 HOH HOH A . G 4 HOH 73 673 99 HOH HOH A . G 4 HOH 74 674 101 HOH HOH A . G 4 HOH 75 675 102 HOH HOH A . G 4 HOH 76 676 105 HOH HOH A . G 4 HOH 77 677 106 HOH HOH A . G 4 HOH 78 678 107 HOH HOH A . G 4 HOH 79 679 108 HOH HOH A . G 4 HOH 80 680 109 HOH HOH A . G 4 HOH 81 681 111 HOH HOH A . G 4 HOH 82 682 112 HOH HOH A . G 4 HOH 83 683 115 HOH HOH A . G 4 HOH 84 684 117 HOH HOH A . G 4 HOH 85 685 118 HOH HOH A . G 4 HOH 86 686 119 HOH HOH A . G 4 HOH 87 687 121 HOH HOH A . G 4 HOH 88 688 122 HOH HOH A . G 4 HOH 89 689 124 HOH HOH A . G 4 HOH 90 690 125 HOH HOH A . G 4 HOH 91 691 126 HOH HOH A . G 4 HOH 92 692 128 HOH HOH A . G 4 HOH 93 693 131 HOH HOH A . G 4 HOH 94 694 135 HOH HOH A . G 4 HOH 95 695 136 HOH HOH A . G 4 HOH 96 696 137 HOH HOH A . G 4 HOH 97 697 138 HOH HOH A . G 4 HOH 98 698 147 HOH HOH A . G 4 HOH 99 699 148 HOH HOH A . G 4 HOH 100 700 154 HOH HOH A . G 4 HOH 101 701 156 HOH HOH A . G 4 HOH 102 702 159 HOH HOH A . G 4 HOH 103 703 160 HOH HOH A . G 4 HOH 104 704 162 HOH HOH A . G 4 HOH 105 705 166 HOH HOH A . G 4 HOH 106 706 168 HOH HOH A . G 4 HOH 107 707 170 HOH HOH A . G 4 HOH 108 708 171 HOH HOH A . G 4 HOH 109 709 172 HOH HOH A . G 4 HOH 110 710 174 HOH HOH A . G 4 HOH 111 711 179 HOH HOH A . G 4 HOH 112 712 184 HOH HOH A . G 4 HOH 113 713 185 HOH HOH A . G 4 HOH 114 714 186 HOH HOH A . G 4 HOH 115 715 187 HOH HOH A . G 4 HOH 116 716 188 HOH HOH A . G 4 HOH 117 717 189 HOH HOH A . G 4 HOH 118 718 192 HOH HOH A . G 4 HOH 119 719 194 HOH HOH A . G 4 HOH 120 720 195 HOH HOH A . G 4 HOH 121 721 196 HOH HOH A . G 4 HOH 122 722 200 HOH HOH A . G 4 HOH 123 723 201 HOH HOH A . G 4 HOH 124 724 205 HOH HOH A . G 4 HOH 125 725 210 HOH HOH A . G 4 HOH 126 726 211 HOH HOH A . G 4 HOH 127 727 214 HOH HOH A . G 4 HOH 128 728 218 HOH HOH A . G 4 HOH 129 729 219 HOH HOH A . G 4 HOH 130 730 222 HOH HOH A . G 4 HOH 131 731 225 HOH HOH A . G 4 HOH 132 732 226 HOH HOH A . G 4 HOH 133 733 231 HOH HOH A . G 4 HOH 134 734 232 HOH HOH A . G 4 HOH 135 735 236 HOH HOH A . G 4 HOH 136 736 237 HOH HOH A . G 4 HOH 137 737 238 HOH HOH A . G 4 HOH 138 738 239 HOH HOH A . G 4 HOH 139 739 241 HOH HOH A . G 4 HOH 140 740 244 HOH HOH A . G 4 HOH 141 741 248 HOH HOH A . G 4 HOH 142 742 249 HOH HOH A . G 4 HOH 143 743 250 HOH HOH A . G 4 HOH 144 744 251 HOH HOH A . G 4 HOH 145 745 252 HOH HOH A . G 4 HOH 146 746 253 HOH HOH A . G 4 HOH 147 747 254 HOH HOH A . G 4 HOH 148 748 261 HOH HOH A . G 4 HOH 149 749 262 HOH HOH A . G 4 HOH 150 750 263 HOH HOH A . G 4 HOH 151 751 266 HOH HOH A . G 4 HOH 152 752 267 HOH HOH A . G 4 HOH 153 753 268 HOH HOH A . G 4 HOH 154 754 269 HOH HOH A . G 4 HOH 155 755 278 HOH HOH A . G 4 HOH 156 756 282 HOH HOH A . G 4 HOH 157 757 283 HOH HOH A . G 4 HOH 158 758 290 HOH HOH A . G 4 HOH 159 759 291 HOH HOH A . G 4 HOH 160 760 298 HOH HOH A . G 4 HOH 161 761 299 HOH HOH A . G 4 HOH 162 762 302 HOH HOH A . G 4 HOH 163 763 303 HOH HOH A . G 4 HOH 164 764 305 HOH HOH A . G 4 HOH 165 765 307 HOH HOH A . H 4 HOH 1 601 91 HOH HOH B . H 4 HOH 2 602 54 HOH HOH B . H 4 HOH 3 603 81 HOH HOH B . H 4 HOH 4 604 114 HOH HOH B . H 4 HOH 5 605 20 HOH HOH B . H 4 HOH 6 606 116 HOH HOH B . H 4 HOH 7 607 123 HOH HOH B . H 4 HOH 8 608 26 HOH HOH B . H 4 HOH 9 609 276 HOH HOH B . H 4 HOH 10 610 275 HOH HOH B . H 4 HOH 11 611 206 HOH HOH B . H 4 HOH 12 612 86 HOH HOH B . H 4 HOH 13 613 55 HOH HOH B . H 4 HOH 14 614 96 HOH HOH B . H 4 HOH 15 615 279 HOH HOH B . H 4 HOH 16 616 120 HOH HOH B . H 4 HOH 17 617 18 HOH HOH B . H 4 HOH 18 618 240 HOH HOH B . H 4 HOH 19 619 228 HOH HOH B . H 4 HOH 20 620 31 HOH HOH B . H 4 HOH 21 621 197 HOH HOH B . H 4 HOH 22 622 5 HOH HOH B . H 4 HOH 23 623 9 HOH HOH B . H 4 HOH 24 624 11 HOH HOH B . H 4 HOH 25 625 14 HOH HOH B . H 4 HOH 26 626 23 HOH HOH B . H 4 HOH 27 627 24 HOH HOH B . H 4 HOH 28 628 25 HOH HOH B . H 4 HOH 29 629 27 HOH HOH B . H 4 HOH 30 630 38 HOH HOH B . H 4 HOH 31 631 39 HOH HOH B . H 4 HOH 32 632 45 HOH HOH B . H 4 HOH 33 633 46 HOH HOH B . H 4 HOH 34 634 48 HOH HOH B . H 4 HOH 35 635 60 HOH HOH B . H 4 HOH 36 636 61 HOH HOH B . H 4 HOH 37 637 62 HOH HOH B . H 4 HOH 38 638 63 HOH HOH B . H 4 HOH 39 639 71 HOH HOH B . H 4 HOH 40 640 73 HOH HOH B . H 4 HOH 41 641 77 HOH HOH B . H 4 HOH 42 642 82 HOH HOH B . H 4 HOH 43 643 92 HOH HOH B . H 4 HOH 44 644 93 HOH HOH B . H 4 HOH 45 645 97 HOH HOH B . H 4 HOH 46 646 98 HOH HOH B . H 4 HOH 47 647 100 HOH HOH B . H 4 HOH 48 648 103 HOH HOH B . H 4 HOH 49 649 104 HOH HOH B . H 4 HOH 50 650 110 HOH HOH B . H 4 HOH 51 651 113 HOH HOH B . H 4 HOH 52 652 127 HOH HOH B . H 4 HOH 53 653 129 HOH HOH B . H 4 HOH 54 654 130 HOH HOH B . H 4 HOH 55 655 133 HOH HOH B . H 4 HOH 56 656 139 HOH HOH B . H 4 HOH 57 657 140 HOH HOH B . H 4 HOH 58 658 141 HOH HOH B . H 4 HOH 59 659 142 HOH HOH B . H 4 HOH 60 660 143 HOH HOH B . H 4 HOH 61 661 144 HOH HOH B . H 4 HOH 62 662 145 HOH HOH B . H 4 HOH 63 663 146 HOH HOH B . H 4 HOH 64 664 150 HOH HOH B . H 4 HOH 65 665 152 HOH HOH B . H 4 HOH 66 666 155 HOH HOH B . H 4 HOH 67 667 158 HOH HOH B . H 4 HOH 68 668 161 HOH HOH B . H 4 HOH 69 669 164 HOH HOH B . H 4 HOH 70 670 165 HOH HOH B . H 4 HOH 71 671 169 HOH HOH B . H 4 HOH 72 672 176 HOH HOH B . H 4 HOH 73 673 178 HOH HOH B . H 4 HOH 74 674 180 HOH HOH B . H 4 HOH 75 675 181 HOH HOH B . H 4 HOH 76 676 182 HOH HOH B . H 4 HOH 77 677 183 HOH HOH B . H 4 HOH 78 678 190 HOH HOH B . H 4 HOH 79 679 198 HOH HOH B . H 4 HOH 80 680 199 HOH HOH B . H 4 HOH 81 681 202 HOH HOH B . H 4 HOH 82 682 203 HOH HOH B . H 4 HOH 83 683 208 HOH HOH B . H 4 HOH 84 684 215 HOH HOH B . H 4 HOH 85 685 216 HOH HOH B . H 4 HOH 86 686 217 HOH HOH B . H 4 HOH 87 687 221 HOH HOH B . H 4 HOH 88 688 223 HOH HOH B . H 4 HOH 89 689 224 HOH HOH B . H 4 HOH 90 690 227 HOH HOH B . H 4 HOH 91 691 229 HOH HOH B . H 4 HOH 92 692 230 HOH HOH B . H 4 HOH 93 693 233 HOH HOH B . H 4 HOH 94 694 234 HOH HOH B . H 4 HOH 95 695 235 HOH HOH B . H 4 HOH 96 696 247 HOH HOH B . H 4 HOH 97 697 270 HOH HOH B . H 4 HOH 98 698 274 HOH HOH B . H 4 HOH 99 699 277 HOH HOH B . H 4 HOH 100 700 280 HOH HOH B . H 4 HOH 101 701 281 HOH HOH B . H 4 HOH 102 702 284 HOH HOH B . H 4 HOH 103 703 285 HOH HOH B . H 4 HOH 104 704 288 HOH HOH B . H 4 HOH 105 705 294 HOH HOH B . H 4 HOH 106 706 295 HOH HOH B . H 4 HOH 107 707 296 HOH HOH B . H 4 HOH 108 708 297 HOH HOH B . H 4 HOH 109 709 304 HOH HOH B . H 4 HOH 110 710 308 HOH HOH B . H 4 HOH 111 711 310 HOH HOH B . H 4 HOH 112 712 311 HOH HOH B . # loop_ _pdbx_struct_assembly.id _pdbx_struct_assembly.details _pdbx_struct_assembly.method_details _pdbx_struct_assembly.oligomeric_details _pdbx_struct_assembly.oligomeric_count 1 author_defined_assembly ? monomeric 1 2 author_defined_assembly ? monomeric 1 3 software_defined_assembly PISA hexameric 6 4 software_defined_assembly PISA trimeric 3 5 software_defined_assembly PISA trimeric 3 # loop_ _pdbx_struct_assembly_gen.assembly_id _pdbx_struct_assembly_gen.oper_expression _pdbx_struct_assembly_gen.asym_id_list 1 1 A,C,D,G 2 1 B,E,F,H 3 1,2,3 A,B,C,D,E,F,G,H 4 1,2,3 A,C,D,G 5 1,2,3 B,E,F,H # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 3 'ABSA (A^2)' 14850 ? 3 MORE -44 ? 3 'SSA (A^2)' 72910 ? 4 'ABSA (A^2)' 3960 ? 4 MORE -19 ? 4 'SSA (A^2)' 40370 ? 5 'ABSA (A^2)' 4660 ? 5 MORE -22 ? 5 'SSA (A^2)' 38780 ? # loop_ _pdbx_struct_oper_list.id _pdbx_struct_oper_list.type _pdbx_struct_oper_list.name _pdbx_struct_oper_list.symmetry_operation _pdbx_struct_oper_list.matrix[1][1] _pdbx_struct_oper_list.matrix[1][2] _pdbx_struct_oper_list.matrix[1][3] _pdbx_struct_oper_list.vector[1] _pdbx_struct_oper_list.matrix[2][1] _pdbx_struct_oper_list.matrix[2][2] _pdbx_struct_oper_list.matrix[2][3] _pdbx_struct_oper_list.vector[2] _pdbx_struct_oper_list.matrix[3][1] _pdbx_struct_oper_list.matrix[3][2] _pdbx_struct_oper_list.matrix[3][3] _pdbx_struct_oper_list.vector[3] 1 'identity operation' 1_555 x,y,z 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 2 'crystal symmetry operation' 5_555 z,x,y 0.0000000000 0.0000000000 1.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 3 'crystal symmetry operation' 9_555 y,z,x 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 # _pdbx_struct_special_symmetry.id 1 _pdbx_struct_special_symmetry.PDB_model_num 1 _pdbx_struct_special_symmetry.auth_asym_id A _pdbx_struct_special_symmetry.auth_comp_id HOH _pdbx_struct_special_symmetry.auth_seq_id 623 _pdbx_struct_special_symmetry.PDB_ins_code ? _pdbx_struct_special_symmetry.label_asym_id G _pdbx_struct_special_symmetry.label_comp_id HOH _pdbx_struct_special_symmetry.label_seq_id . # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2015-02-18 2 'Structure model' 1 1 2016-03-16 3 'Structure model' 1 2 2017-11-22 4 'Structure model' 1 3 2018-04-18 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Data collection' 2 3 'Structure model' 'Derived calculations' 3 3 'Structure model' 'Refinement description' 4 4 'Structure model' 'Data collection' 5 4 'Structure model' 'Database references' # loop_ _pdbx_audit_revision_category.ordinal _pdbx_audit_revision_category.revision_ordinal _pdbx_audit_revision_category.data_content_type _pdbx_audit_revision_category.category 1 3 'Structure model' pdbx_struct_oper_list 2 3 'Structure model' software 3 4 'Structure model' citation 4 4 'Structure model' citation_author # loop_ _pdbx_audit_revision_item.ordinal _pdbx_audit_revision_item.revision_ordinal _pdbx_audit_revision_item.data_content_type _pdbx_audit_revision_item.item 1 3 'Structure model' '_pdbx_struct_oper_list.symmetry_operation' 2 4 'Structure model' '_citation.journal_abbrev' 3 4 'Structure model' '_citation.journal_volume' 4 4 'Structure model' '_citation.page_first' 5 4 'Structure model' '_citation.page_last' 6 4 'Structure model' '_citation.pdbx_database_id_PubMed' 7 4 'Structure model' '_citation.title' # loop_ _software.citation_id _software.classification _software.compiler_name _software.compiler_version _software.contact_author _software.contact_author_email _software.date _software.description _software.dependencies _software.hardware _software.language _software.location _software.mods _software.name _software.os _software.os_version _software.type _software.version _software.pdbx_ordinal ? refinement ? ? ? ? ? ? ? ? ? ? ? BUSTER-TNT ? ? ? 'BUSTER 2.11.4' 1 ? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? DENZO ? ? ? . 2 ? 'data scaling' ? ? ? ? ? ? ? ? ? ? ? SCALEPACK ? ? ? . 3 ? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? 3.10 4 ? phasing ? ? ? ? ? ? ? ? ? ? ? AMoRE ? ? ? . 5 ? refinement ? ? ? ? ? ? ? ? ? ? ? BUSTER ? ? ? 2.11.4 6 # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 ARG A 119 ? ? -67.97 0.83 2 1 ASN A 141 ? ? -133.29 -68.48 3 1 ARG A 317 ? ? -115.51 -162.72 4 1 ALA A 365 ? ? -92.10 38.79 5 1 ARG B 119 ? ? -67.82 2.42 6 1 ASN B 141 ? ? -132.42 -68.09 7 1 THR B 280 ? ? -80.34 -85.26 8 1 LEU B 281 ? ? 69.78 -3.09 9 1 ARG B 317 ? ? -61.70 -94.95 10 1 LEU B 318 ? ? -125.90 -61.89 11 1 PRO B 329 ? ? -59.06 -8.73 # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 Y 1 A LYS 220 ? CG ? A LYS 154 CG 2 1 Y 1 A LYS 220 ? CD ? A LYS 154 CD 3 1 Y 1 A LYS 220 ? CE ? A LYS 154 CE 4 1 Y 1 A LYS 220 ? NZ ? A LYS 154 NZ 5 1 Y 1 A GLN 236 ? CG ? A GLN 170 CG 6 1 Y 1 A GLN 236 ? CD ? A GLN 170 CD 7 1 Y 1 A GLN 236 ? OE1 ? A GLN 170 OE1 8 1 Y 1 A GLN 236 ? NE2 ? A GLN 170 NE2 9 1 Y 1 A GLN 250 ? CG ? A GLN 184 CG 10 1 Y 1 A GLN 250 ? CD ? A GLN 184 CD 11 1 Y 1 A GLN 250 ? OE1 ? A GLN 184 OE1 12 1 Y 1 A GLN 250 ? NE2 ? A GLN 184 NE2 13 1 Y 1 A LYS 315 ? CG ? A LYS 249 CG 14 1 Y 1 A LYS 315 ? CD ? A LYS 249 CD 15 1 Y 1 A LYS 315 ? CE ? A LYS 249 CE 16 1 Y 1 A LYS 315 ? NZ ? A LYS 249 NZ 17 1 Y 1 A LYS 341 ? CG ? A LYS 275 CG 18 1 Y 1 A LYS 341 ? CD ? A LYS 275 CD 19 1 Y 1 A LYS 341 ? CE ? A LYS 275 CE 20 1 Y 1 A LYS 341 ? NZ ? A LYS 275 NZ 21 1 Y 1 A LYS 359 ? CG ? A LYS 293 CG 22 1 Y 1 A LYS 359 ? CD ? A LYS 293 CD 23 1 Y 1 A LYS 359 ? CE ? A LYS 293 CE 24 1 Y 1 A LYS 359 ? NZ ? A LYS 293 NZ 25 1 Y 1 A LYS 360 ? CG ? A LYS 294 CG 26 1 Y 1 A LYS 360 ? CD ? A LYS 294 CD 27 1 Y 1 A LYS 360 ? CE ? A LYS 294 CE 28 1 Y 1 A LYS 360 ? NZ ? A LYS 294 NZ 29 1 Y 1 A ARG 396 ? CD ? A ARG 330 CD 30 1 Y 1 A ARG 396 ? NE ? A ARG 330 NE 31 1 Y 1 A ARG 396 ? CZ ? A ARG 330 CZ 32 1 Y 1 A ARG 396 ? NH1 ? A ARG 330 NH1 33 1 Y 1 A ARG 396 ? NH2 ? A ARG 330 NH2 34 1 Y 1 B ARG 119 ? CG ? B ARG 53 CG 35 1 Y 1 B ARG 119 ? CD ? B ARG 53 CD 36 1 Y 1 B ARG 119 ? NE ? B ARG 53 NE 37 1 Y 1 B ARG 119 ? CZ ? B ARG 53 CZ 38 1 Y 1 B ARG 119 ? NH1 ? B ARG 53 NH1 39 1 Y 1 B ARG 119 ? NH2 ? B ARG 53 NH2 40 1 Y 1 B TYR 126 ? CG ? B TYR 60 CG 41 1 Y 1 B TYR 126 ? CD1 ? B TYR 60 CD1 42 1 Y 1 B TYR 126 ? CD2 ? B TYR 60 CD2 43 1 Y 1 B TYR 126 ? CE1 ? B TYR 60 CE1 44 1 Y 1 B TYR 126 ? CE2 ? B TYR 60 CE2 45 1 Y 1 B TYR 126 ? CZ ? B TYR 60 CZ 46 1 Y 1 B TYR 126 ? OH ? B TYR 60 OH 47 1 Y 1 B LYS 139 ? CG ? B LYS 73 CG 48 1 Y 1 B LYS 139 ? CD ? B LYS 73 CD 49 1 Y 1 B LYS 139 ? CE ? B LYS 73 CE 50 1 Y 1 B LYS 139 ? NZ ? B LYS 73 NZ 51 1 Y 1 B GLU 144 ? CG ? B GLU 78 CG 52 1 Y 1 B GLU 144 ? CD ? B GLU 78 CD 53 1 Y 1 B GLU 144 ? OE1 ? B GLU 78 OE1 54 1 Y 1 B GLU 144 ? OE2 ? B GLU 78 OE2 55 1 Y 1 B ARG 148 ? CG ? B ARG 82 CG 56 1 Y 1 B ARG 148 ? CD ? B ARG 82 CD 57 1 Y 1 B ARG 148 ? NE ? B ARG 82 NE 58 1 Y 1 B ARG 148 ? CZ ? B ARG 82 CZ 59 1 Y 1 B ARG 148 ? NH1 ? B ARG 82 NH1 60 1 Y 1 B ARG 148 ? NH2 ? B ARG 82 NH2 61 1 Y 1 B GLU 179 ? CG ? B GLU 113 CG 62 1 Y 1 B GLU 179 ? CD ? B GLU 113 CD 63 1 Y 1 B GLU 179 ? OE1 ? B GLU 113 OE1 64 1 Y 1 B GLU 179 ? OE2 ? B GLU 113 OE2 65 1 Y 1 B ARG 205 ? CG ? B ARG 139 CG 66 1 Y 1 B ARG 205 ? CD ? B ARG 139 CD 67 1 Y 1 B ARG 205 ? NE ? B ARG 139 NE 68 1 Y 1 B ARG 205 ? CZ ? B ARG 139 CZ 69 1 Y 1 B ARG 205 ? NH1 ? B ARG 139 NH1 70 1 Y 1 B ARG 205 ? NH2 ? B ARG 139 NH2 71 1 Y 1 B LYS 220 ? CG ? B LYS 154 CG 72 1 Y 1 B LYS 220 ? CD ? B LYS 154 CD 73 1 Y 1 B LYS 220 ? CE ? B LYS 154 CE 74 1 Y 1 B LYS 220 ? NZ ? B LYS 154 NZ 75 1 Y 1 B LYS 272 ? CG ? B LYS 206 CG 76 1 Y 1 B LYS 272 ? CD ? B LYS 206 CD 77 1 Y 1 B LYS 272 ? CE ? B LYS 206 CE 78 1 Y 1 B LYS 272 ? NZ ? B LYS 206 NZ 79 1 Y 1 B LEU 281 ? CG ? B LEU 215 CG 80 1 Y 1 B LEU 281 ? CD1 ? B LEU 215 CD1 81 1 Y 1 B LEU 281 ? CD2 ? B LEU 215 CD2 82 1 Y 1 B GLU 284 ? CG ? B GLU 218 CG 83 1 Y 1 B GLU 284 ? CD ? B GLU 218 CD 84 1 Y 1 B GLU 284 ? OE1 ? B GLU 218 OE1 85 1 Y 1 B GLU 284 ? OE2 ? B GLU 218 OE2 86 1 Y 1 B LYS 307 ? CG ? B LYS 241 CG 87 1 Y 1 B LYS 307 ? CD ? B LYS 241 CD 88 1 Y 1 B LYS 307 ? CE ? B LYS 241 CE 89 1 Y 1 B LYS 307 ? NZ ? B LYS 241 NZ 90 1 Y 1 B LYS 315 ? CG ? B LYS 249 CG 91 1 Y 1 B LYS 315 ? CD ? B LYS 249 CD 92 1 Y 1 B LYS 315 ? CE ? B LYS 249 CE 93 1 Y 1 B LYS 315 ? NZ ? B LYS 249 NZ 94 1 Y 1 B LYS 341 ? CG ? B LYS 275 CG 95 1 Y 1 B LYS 341 ? CD ? B LYS 275 CD 96 1 Y 1 B LYS 341 ? CE ? B LYS 275 CE 97 1 Y 1 B LYS 341 ? NZ ? B LYS 275 NZ 98 1 Y 1 B GLU 354 ? CG ? B GLU 288 CG 99 1 Y 1 B GLU 354 ? CD ? B GLU 288 CD 100 1 Y 1 B GLU 354 ? OE1 ? B GLU 288 OE1 101 1 Y 1 B GLU 354 ? OE2 ? B GLU 288 OE2 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A LEU 67 ? A LEU 1 2 1 Y 1 B GLU 233 ? B GLU 167 3 1 Y 1 B ASN 234 ? B ASN 168 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 'N-benzyl-3-{[(2Z,4S)-2-imino-4-methyl-6-oxo-4-(propan-2-yl)tetrahydropyrimidin-1(2H)-yl]methyl}benzamide' 70X 4 water HOH #