data_4RS0 # _entry.id 4RS0 # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.281 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code RCSB RCSB087725 PDB 4RS0 WWPDB D_1000087725 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.details _pdbx_database_related.content_type PDB 4RRW . unspecified PDB 4RRX . unspecified PDB 4RRY . unspecified PDB 4RRZ . unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 4RS0 _pdbx_database_status.recvd_initial_deposition_date 2014-11-06 _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry ? _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? _pdbx_database_status.pdb_format_compatible Y # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Xu, S.' 1 'Blobaum, A.L.' 2 'Banerjee, S.' 3 'Marnett, L.J.' 4 # _citation.id primary _citation.title ;Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2. ; _citation.journal_abbrev J.Biol.Chem. _citation.journal_volume 290 _citation.page_first 12793 _citation.page_last 12803 _citation.year 2015 _citation.journal_id_ASTM JBCHA3 _citation.country US _citation.journal_id_ISSN 0021-9258 _citation.journal_id_CSD 0071 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 25825493 _citation.pdbx_database_id_DOI 10.1074/jbc.M114.635987 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Blobaum, A.L.' 1 primary 'Xu, S.' 2 primary 'Rowlinson, S.W.' 3 primary 'Duggan, K.C.' 4 primary 'Banerjee, S.' 5 primary 'Kudalkar, S.N.' 6 primary 'Birmingham, W.R.' 7 primary 'Ghebreselasie, K.' 8 primary 'Marnett, L.J.' 9 # _cell.entry_id 4RS0 _cell.length_a 173.207 _cell.length_b 173.207 _cell.length_c 204.364 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 90.00 _cell.Z_PDB 16 _cell.pdbx_unique_axis ? _cell.length_a_esd ? _cell.length_b_esd ? _cell.length_c_esd ? _cell.angle_alpha_esd ? _cell.angle_beta_esd ? _cell.angle_gamma_esd ? # _symmetry.entry_id 4RS0 _symmetry.space_group_name_H-M 'I 41 2 2' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 98 _symmetry.space_group_name_Hall ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'Prostaglandin G/H synthase 2' 67380.773 1 1.14.99.1 H90W ? ? 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 4 ? ? ? ? 3 non-polymer man B-OCTYLGLUCOSIDE 292.369 1 ? ? ? ? 4 non-polymer syn IBUPROFEN 206.281 1 ? ? ? ? 5 water nat water 18.015 108 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name ;Cyclooxygenase-2, COX-2, Glucocorticoid-regulated inflammatory cyclooxygenase, Gripghs, Macrophage activation-associated marker protein P71/73, PES-2, PHS II, Prostaglandin H2 synthase 2, PGH synthase 2, PGHS-2, Prostaglandin-endoperoxide synthase 2, TIS10 protein ; # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;ANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVWYILTHFKGVWNIVNNIPFLRSL IMKYVLTSRSYLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDP QGSNMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTQV EMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQH LSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIA GRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDVMELYPALLVEK PRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTA TINASASHSRLDDINPTVLIKRRSTEL ; _entity_poly.pdbx_seq_one_letter_code_can ;ANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVWYILTHFKGVWNIVNNIPFLRSL IMKYVLTSRSYLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDP QGSNMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTQV EMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQH LSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIA GRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDVMELYPALLVEK PRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTA TINASASHSRLDDINPTVLIKRRSTEL ; _entity_poly.pdbx_strand_id A _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 ALA n 1 2 ASN n 1 3 PRO n 1 4 CYS n 1 5 CYS n 1 6 SER n 1 7 ASN n 1 8 PRO n 1 9 CYS n 1 10 GLN n 1 11 ASN n 1 12 ARG n 1 13 GLY n 1 14 GLU n 1 15 CYS n 1 16 MET n 1 17 SER n 1 18 THR n 1 19 GLY n 1 20 PHE n 1 21 ASP n 1 22 GLN n 1 23 TYR n 1 24 LYS n 1 25 CYS n 1 26 ASP n 1 27 CYS n 1 28 THR n 1 29 ARG n 1 30 THR n 1 31 GLY n 1 32 PHE n 1 33 TYR n 1 34 GLY n 1 35 GLU n 1 36 ASN n 1 37 CYS n 1 38 THR n 1 39 THR n 1 40 PRO n 1 41 GLU n 1 42 PHE n 1 43 LEU n 1 44 THR n 1 45 ARG n 1 46 ILE n 1 47 LYS n 1 48 LEU n 1 49 LEU n 1 50 LEU n 1 51 LYS n 1 52 PRO n 1 53 THR n 1 54 PRO n 1 55 ASN n 1 56 THR n 1 57 VAL n 1 58 TRP n 1 59 TYR n 1 60 ILE n 1 61 LEU n 1 62 THR n 1 63 HIS n 1 64 PHE n 1 65 LYS n 1 66 GLY n 1 67 VAL n 1 68 TRP n 1 69 ASN n 1 70 ILE n 1 71 VAL n 1 72 ASN n 1 73 ASN n 1 74 ILE n 1 75 PRO n 1 76 PHE n 1 77 LEU n 1 78 ARG n 1 79 SER n 1 80 LEU n 1 81 ILE n 1 82 MET n 1 83 LYS n 1 84 TYR n 1 85 VAL n 1 86 LEU n 1 87 THR n 1 88 SER n 1 89 ARG n 1 90 SER n 1 91 TYR n 1 92 LEU n 1 93 ILE n 1 94 ASP n 1 95 SER n 1 96 PRO n 1 97 PRO n 1 98 THR n 1 99 TYR n 1 100 ASN n 1 101 VAL n 1 102 HIS n 1 103 TYR n 1 104 GLY n 1 105 TYR n 1 106 LYS n 1 107 SER n 1 108 TRP n 1 109 GLU n 1 110 ALA n 1 111 PHE n 1 112 SER n 1 113 ASN n 1 114 LEU n 1 115 SER n 1 116 TYR n 1 117 TYR n 1 118 THR n 1 119 ARG n 1 120 ALA n 1 121 LEU n 1 122 PRO n 1 123 PRO n 1 124 VAL n 1 125 ALA n 1 126 ASP n 1 127 ASP n 1 128 CYS n 1 129 PRO n 1 130 THR n 1 131 PRO n 1 132 MET n 1 133 GLY n 1 134 VAL n 1 135 LYS n 1 136 GLY n 1 137 ASN n 1 138 LYS n 1 139 GLU n 1 140 LEU n 1 141 PRO n 1 142 ASP n 1 143 SER n 1 144 LYS n 1 145 GLU n 1 146 VAL n 1 147 LEU n 1 148 GLU n 1 149 LYS n 1 150 VAL n 1 151 LEU n 1 152 LEU n 1 153 ARG n 1 154 ARG n 1 155 GLU n 1 156 PHE n 1 157 ILE n 1 158 PRO n 1 159 ASP n 1 160 PRO n 1 161 GLN n 1 162 GLY n 1 163 SER n 1 164 ASN n 1 165 MET n 1 166 MET n 1 167 PHE n 1 168 ALA n 1 169 PHE n 1 170 PHE n 1 171 ALA n 1 172 GLN n 1 173 HIS n 1 174 PHE n 1 175 THR n 1 176 HIS n 1 177 GLN n 1 178 PHE n 1 179 PHE n 1 180 LYS n 1 181 THR n 1 182 ASP n 1 183 HIS n 1 184 LYS n 1 185 ARG n 1 186 GLY n 1 187 PRO n 1 188 GLY n 1 189 PHE n 1 190 THR n 1 191 ARG n 1 192 GLY n 1 193 LEU n 1 194 GLY n 1 195 HIS n 1 196 GLY n 1 197 VAL n 1 198 ASP n 1 199 LEU n 1 200 ASN n 1 201 HIS n 1 202 ILE n 1 203 TYR n 1 204 GLY n 1 205 GLU n 1 206 THR n 1 207 LEU n 1 208 ASP n 1 209 ARG n 1 210 GLN n 1 211 HIS n 1 212 LYS n 1 213 LEU n 1 214 ARG n 1 215 LEU n 1 216 PHE n 1 217 LYS n 1 218 ASP n 1 219 GLY n 1 220 LYS n 1 221 LEU n 1 222 LYS n 1 223 TYR n 1 224 GLN n 1 225 VAL n 1 226 ILE n 1 227 GLY n 1 228 GLY n 1 229 GLU n 1 230 VAL n 1 231 TYR n 1 232 PRO n 1 233 PRO n 1 234 THR n 1 235 VAL n 1 236 LYS n 1 237 ASP n 1 238 THR n 1 239 GLN n 1 240 VAL n 1 241 GLU n 1 242 MET n 1 243 ILE n 1 244 TYR n 1 245 PRO n 1 246 PRO n 1 247 HIS n 1 248 ILE n 1 249 PRO n 1 250 GLU n 1 251 ASN n 1 252 LEU n 1 253 GLN n 1 254 PHE n 1 255 ALA n 1 256 VAL n 1 257 GLY n 1 258 GLN n 1 259 GLU n 1 260 VAL n 1 261 PHE n 1 262 GLY n 1 263 LEU n 1 264 VAL n 1 265 PRO n 1 266 GLY n 1 267 LEU n 1 268 MET n 1 269 MET n 1 270 TYR n 1 271 ALA n 1 272 THR n 1 273 ILE n 1 274 TRP n 1 275 LEU n 1 276 ARG n 1 277 GLU n 1 278 HIS n 1 279 ASN n 1 280 ARG n 1 281 VAL n 1 282 CYS n 1 283 ASP n 1 284 ILE n 1 285 LEU n 1 286 LYS n 1 287 GLN n 1 288 GLU n 1 289 HIS n 1 290 PRO n 1 291 GLU n 1 292 TRP n 1 293 GLY n 1 294 ASP n 1 295 GLU n 1 296 GLN n 1 297 LEU n 1 298 PHE n 1 299 GLN n 1 300 THR n 1 301 SER n 1 302 ARG n 1 303 LEU n 1 304 ILE n 1 305 LEU n 1 306 ILE n 1 307 GLY n 1 308 GLU n 1 309 THR n 1 310 ILE n 1 311 LYS n 1 312 ILE n 1 313 VAL n 1 314 ILE n 1 315 GLU n 1 316 ASP n 1 317 TYR n 1 318 VAL n 1 319 GLN n 1 320 HIS n 1 321 LEU n 1 322 SER n 1 323 GLY n 1 324 TYR n 1 325 HIS n 1 326 PHE n 1 327 LYS n 1 328 LEU n 1 329 LYS n 1 330 PHE n 1 331 ASP n 1 332 PRO n 1 333 GLU n 1 334 LEU n 1 335 LEU n 1 336 PHE n 1 337 ASN n 1 338 GLN n 1 339 GLN n 1 340 PHE n 1 341 GLN n 1 342 TYR n 1 343 GLN n 1 344 ASN n 1 345 ARG n 1 346 ILE n 1 347 ALA n 1 348 SER n 1 349 GLU n 1 350 PHE n 1 351 ASN n 1 352 THR n 1 353 LEU n 1 354 TYR n 1 355 HIS n 1 356 TRP n 1 357 HIS n 1 358 PRO n 1 359 LEU n 1 360 LEU n 1 361 PRO n 1 362 ASP n 1 363 THR n 1 364 PHE n 1 365 ASN n 1 366 ILE n 1 367 GLU n 1 368 ASP n 1 369 GLN n 1 370 GLU n 1 371 TYR n 1 372 SER n 1 373 PHE n 1 374 LYS n 1 375 GLN n 1 376 PHE n 1 377 LEU n 1 378 TYR n 1 379 ASN n 1 380 ASN n 1 381 SER n 1 382 ILE n 1 383 LEU n 1 384 LEU n 1 385 GLU n 1 386 HIS n 1 387 GLY n 1 388 LEU n 1 389 THR n 1 390 GLN n 1 391 PHE n 1 392 VAL n 1 393 GLU n 1 394 SER n 1 395 PHE n 1 396 THR n 1 397 ARG n 1 398 GLN n 1 399 ILE n 1 400 ALA n 1 401 GLY n 1 402 ARG n 1 403 VAL n 1 404 ALA n 1 405 GLY n 1 406 GLY n 1 407 ARG n 1 408 ASN n 1 409 VAL n 1 410 PRO n 1 411 ILE n 1 412 ALA n 1 413 VAL n 1 414 GLN n 1 415 ALA n 1 416 VAL n 1 417 ALA n 1 418 LYS n 1 419 ALA n 1 420 SER n 1 421 ILE n 1 422 ASP n 1 423 GLN n 1 424 SER n 1 425 ARG n 1 426 GLU n 1 427 MET n 1 428 LYS n 1 429 TYR n 1 430 GLN n 1 431 SER n 1 432 LEU n 1 433 ASN n 1 434 GLU n 1 435 TYR n 1 436 ARG n 1 437 LYS n 1 438 ARG n 1 439 PHE n 1 440 SER n 1 441 LEU n 1 442 LYS n 1 443 PRO n 1 444 TYR n 1 445 THR n 1 446 SER n 1 447 PHE n 1 448 GLU n 1 449 GLU n 1 450 LEU n 1 451 THR n 1 452 GLY n 1 453 GLU n 1 454 LYS n 1 455 GLU n 1 456 MET n 1 457 ALA n 1 458 ALA n 1 459 GLU n 1 460 LEU n 1 461 LYS n 1 462 ALA n 1 463 LEU n 1 464 TYR n 1 465 SER n 1 466 ASP n 1 467 ILE n 1 468 ASP n 1 469 VAL n 1 470 MET n 1 471 GLU n 1 472 LEU n 1 473 TYR n 1 474 PRO n 1 475 ALA n 1 476 LEU n 1 477 LEU n 1 478 VAL n 1 479 GLU n 1 480 LYS n 1 481 PRO n 1 482 ARG n 1 483 PRO n 1 484 ASP n 1 485 ALA n 1 486 ILE n 1 487 PHE n 1 488 GLY n 1 489 GLU n 1 490 THR n 1 491 MET n 1 492 VAL n 1 493 GLU n 1 494 LEU n 1 495 GLY n 1 496 ALA n 1 497 PRO n 1 498 PHE n 1 499 SER n 1 500 LEU n 1 501 LYS n 1 502 GLY n 1 503 LEU n 1 504 MET n 1 505 GLY n 1 506 ASN n 1 507 PRO n 1 508 ILE n 1 509 CYS n 1 510 SER n 1 511 PRO n 1 512 GLN n 1 513 TYR n 1 514 TRP n 1 515 LYS n 1 516 PRO n 1 517 SER n 1 518 THR n 1 519 PHE n 1 520 GLY n 1 521 GLY n 1 522 GLU n 1 523 VAL n 1 524 GLY n 1 525 PHE n 1 526 LYS n 1 527 ILE n 1 528 ILE n 1 529 ASN n 1 530 THR n 1 531 ALA n 1 532 SER n 1 533 ILE n 1 534 GLN n 1 535 SER n 1 536 LEU n 1 537 ILE n 1 538 CYS n 1 539 ASN n 1 540 ASN n 1 541 VAL n 1 542 LYS n 1 543 GLY n 1 544 CYS n 1 545 PRO n 1 546 PHE n 1 547 THR n 1 548 SER n 1 549 PHE n 1 550 ASN n 1 551 VAL n 1 552 GLN n 1 553 ASP n 1 554 PRO n 1 555 GLN n 1 556 PRO n 1 557 THR n 1 558 LYS n 1 559 THR n 1 560 ALA n 1 561 THR n 1 562 ILE n 1 563 ASN n 1 564 ALA n 1 565 SER n 1 566 ALA n 1 567 SER n 1 568 HIS n 1 569 SER n 1 570 ARG n 1 571 LEU n 1 572 ASP n 1 573 ASP n 1 574 ILE n 1 575 ASN n 1 576 PRO n 1 577 THR n 1 578 VAL n 1 579 LEU n 1 580 ILE n 1 581 LYS n 1 582 ARG n 1 583 ARG n 1 584 SER n 1 585 THR n 1 586 GLU n 1 587 LEU n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name mouse _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene 'Ptgs2, Cox-2, Cox2, Pghs-b, Tis10' _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Mus musculus' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 10090 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'Spodoptera frugiperda' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 7108 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain baculovirus _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type ? _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name pVL1393 _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code PGH2_MOUSE _struct_ref.pdbx_db_accession Q05769 _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;ANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSL IMKYVLTSRSYLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDP QGSNMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTQV EMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQH LSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIA GRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDVMELYPALLVEK PRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTA TINASASHSRLDDINPTVLIKRRSTEL ; _struct_ref.pdbx_align_begin 18 _struct_ref.pdbx_db_isoform ? # _struct_ref_seq.align_id 1 _struct_ref_seq.ref_id 1 _struct_ref_seq.pdbx_PDB_id_code 4RS0 _struct_ref_seq.pdbx_strand_id A _struct_ref_seq.seq_align_beg 1 _struct_ref_seq.pdbx_seq_align_beg_ins_code ? _struct_ref_seq.seq_align_end 587 _struct_ref_seq.pdbx_seq_align_end_ins_code ? _struct_ref_seq.pdbx_db_accession Q05769 _struct_ref_seq.db_align_beg 18 _struct_ref_seq.pdbx_db_align_beg_ins_code ? _struct_ref_seq.db_align_end 604 _struct_ref_seq.pdbx_db_align_end_ins_code ? _struct_ref_seq.pdbx_auth_seq_align_beg 33 _struct_ref_seq.pdbx_auth_seq_align_end 618 # _struct_ref_seq_dif.align_id 1 _struct_ref_seq_dif.pdbx_pdb_id_code 4RS0 _struct_ref_seq_dif.mon_id TRP _struct_ref_seq_dif.pdbx_pdb_strand_id A _struct_ref_seq_dif.seq_num 58 _struct_ref_seq_dif.pdbx_pdb_ins_code ? _struct_ref_seq_dif.pdbx_seq_db_name UNP _struct_ref_seq_dif.pdbx_seq_db_accession_code Q05769 _struct_ref_seq_dif.db_mon_id HIS _struct_ref_seq_dif.pdbx_seq_db_seq_num 75 _struct_ref_seq_dif.details 'ENGINEERED MUTATION' _struct_ref_seq_dif.pdbx_auth_seq_num 90 _struct_ref_seq_dif.pdbx_ordinal 1 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 BOG saccharide . B-OCTYLGLUCOSIDE ? 'C14 H28 O6' 292.369 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 IBP non-polymer . IBUPROFEN '2-(4-ISOBUTYLPHENYL)PROPIONIC ACID' 'C13 H18 O2' 206.281 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 4RS0 _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 5.69 _exptl_crystal.density_percent_sol 78.37 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.temp 291 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 8 _exptl_crystal_grow.pdbx_details '50 mM EPPS pH 8.0, 20~25% PEG MME 550, 80~120 mM MgCl2, VAPOR DIFFUSION, HANGING DROP, temperature 291K' _exptl_crystal_grow.pdbx_pH_range ? # _diffrn.id 1 _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type 'ADSC QUANTUM 315' _diffrn_detector.pdbx_collection_date 2012-10-05 _diffrn_detector.details ? # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator GRAPHITE _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.97918 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'APS BEAMLINE 24-ID-E' _diffrn_source.pdbx_synchrotron_site APS _diffrn_source.pdbx_synchrotron_beamline 24-ID-E _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list 0.97918 # _reflns.entry_id 4RS0 _reflns.observed_criterion_sigma_I 0 _reflns.observed_criterion_sigma_F 0 _reflns.d_resolution_low 48.275 _reflns.d_resolution_high 2.807 _reflns.number_obs 38044 _reflns.number_all 38122 _reflns.percent_possible_obs 99.69 _reflns.pdbx_Rmerge_I_obs 0.137 _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI 7.5 _reflns.B_iso_Wilson_estimate 50.1 _reflns.pdbx_redundancy 7.5 _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # _reflns_shell.d_res_high 2.81 _reflns_shell.d_res_low 2.91 _reflns_shell.percent_possible_all 96.96 _reflns_shell.Rmerge_I_obs 0.809 _reflns_shell.pdbx_Rsym_value ? _reflns_shell.meanI_over_sigI_obs 3.0 _reflns_shell.pdbx_redundancy 8.2 _reflns_shell.percent_possible_obs ? _reflns_shell.number_unique_all 3631 _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_unique_obs ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 # _refine.entry_id 4RS0 _refine.ls_number_reflns_obs 38033 _refine.ls_number_reflns_all 38044 _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F 1.35 _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 48.275 _refine.ls_d_res_high 2.807 _refine.ls_percent_reflns_obs 99.66 _refine.ls_R_factor_obs 0.1735 _refine.ls_R_factor_all 0.174 _refine.ls_R_factor_R_work 0.1722 _refine.ls_R_factor_R_free 0.1982 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 5.01 _refine.ls_number_reflns_R_free 1906 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc ? _refine.correlation_coeff_Fo_to_Fc_free ? _refine.B_iso_mean ? _refine.aniso_B[1][1] ? _refine.aniso_B[2][2] ? _refine.aniso_B[3][3] ? _refine.aniso_B[1][2] ? _refine.aniso_B[1][3] ? _refine.aniso_B[2][3] ? _refine.solvent_model_details 'FLAT BULK SOLVENT MODEL' _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.11 _refine.pdbx_solvent_ion_probe_radii ? _refine.pdbx_solvent_shrinkage_radii 0.90 _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details ? _refine.pdbx_starting_model 3NT1 _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model Isotropic _refine.pdbx_stereochemistry_target_values ML _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R ? _refine.pdbx_overall_ESU_R_Free ? _refine.overall_SU_ML 0.26 _refine.pdbx_overall_phase_error 19.84 _refine.overall_SU_B ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_diffrn_id 1 _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 4516 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 91 _refine_hist.number_atoms_solvent 108 _refine_hist.number_atoms_total 4715 _refine_hist.d_res_high 2.807 _refine_hist.d_res_low 48.275 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_restraint_function _refine_ls_restr.pdbx_refine_id f_bond_d 0.002 ? ? 4746 ? 'X-RAY DIFFRACTION' f_angle_d 0.652 ? ? 6437 ? 'X-RAY DIFFRACTION' f_dihedral_angle_d 13.433 ? ? 1753 ? 'X-RAY DIFFRACTION' f_chiral_restr 0.027 ? ? 693 ? 'X-RAY DIFFRACTION' f_plane_restr 0.003 ? ? 829 ? 'X-RAY DIFFRACTION' # loop_ _refine_ls_shell.pdbx_total_number_of_bins_used _refine_ls_shell.d_res_high _refine_ls_shell.d_res_low _refine_ls_shell.number_reflns_R_work _refine_ls_shell.R_factor_R_work _refine_ls_shell.percent_reflns_obs _refine_ls_shell.R_factor_R_free _refine_ls_shell.R_factor_R_free_error _refine_ls_shell.percent_reflns_R_free _refine_ls_shell.number_reflns_R_free _refine_ls_shell.number_reflns_all _refine_ls_shell.R_factor_all _refine_ls_shell.number_reflns_obs _refine_ls_shell.redundancy_reflns_obs _refine_ls_shell.pdbx_refine_id . 2.8070 2.8772 2440 0.2533 96.00 0.2833 . . 127 . . . . 'X-RAY DIFFRACTION' . 2.8772 2.9550 2556 0.2392 100.00 0.2555 . . 141 . . . . 'X-RAY DIFFRACTION' . 2.9550 3.0419 2539 0.2267 100.00 0.2512 . . 133 . . . . 'X-RAY DIFFRACTION' . 3.0419 3.1401 2567 0.2230 100.00 0.2793 . . 132 . . . . 'X-RAY DIFFRACTION' . 3.1401 3.2523 2558 0.2052 100.00 0.2472 . . 123 . . . . 'X-RAY DIFFRACTION' . 3.2523 3.3825 2578 0.2046 100.00 0.2564 . . 119 . . . . 'X-RAY DIFFRACTION' . 3.3825 3.5364 2566 0.1875 100.00 0.2338 . . 147 . . . . 'X-RAY DIFFRACTION' . 3.5364 3.7228 2563 0.1677 100.00 0.1743 . . 144 . . . . 'X-RAY DIFFRACTION' . 3.7228 3.9559 2575 0.1479 100.00 0.1768 . . 136 . . . . 'X-RAY DIFFRACTION' . 3.9559 4.2612 2571 0.1377 100.00 0.1531 . . 140 . . . . 'X-RAY DIFFRACTION' . 4.2612 4.6897 2609 0.1335 100.00 0.1476 . . 140 . . . . 'X-RAY DIFFRACTION' . 4.6897 5.3675 2620 0.1331 100.00 0.1636 . . 128 . . . . 'X-RAY DIFFRACTION' . 5.3675 6.7596 2607 0.1790 100.00 0.1862 . . 167 . . . . 'X-RAY DIFFRACTION' . 6.7596 48.2819 2778 0.1740 100.00 0.2058 . . 129 . . . . 'X-RAY DIFFRACTION' # _struct.entry_id 4RS0 _struct.title 'Crystal Structure of Murine H90W Cyclooxygenase-2 Complexed with S-ibuprofen' _struct.pdbx_descriptor 'Prostaglandin G/H synthase 2 (E.C.1.14.99.1)' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 4RS0 _struct_keywords.pdbx_keywords OXIDOREDUCTASE _struct_keywords.text 'NSAID, protein-drug complex, prostaglandin-endoperoxide synthase, glycosylation, membrane, OXIDOREDUCTASE' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 2 ? D N N 3 ? E N N 2 ? F N N 2 ? G N N 4 ? H N N 5 ? # _struct_biol.id 1 _struct_biol.details ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 GLU A 41 ? LYS A 51 ? GLU A 73 LYS A 83 1 ? 11 HELX_P HELX_P2 2 THR A 53 ? HIS A 63 ? THR A 85 HIS A 95 1 ? 11 HELX_P HELX_P3 3 PHE A 64 ? ASN A 72 ? PHE A 96 ASN A 104 1 ? 9 HELX_P HELX_P4 4 ILE A 74 A TYR A 91 ? ILE A 105 TYR A 122 1 ? 18 HELX_P HELX_P5 5 SER A 107 ? ASN A 113 ? SER A 138 ASN A 144 1 ? 7 HELX_P HELX_P6 6 ASP A 142 ? LEU A 151 ? ASP A 173 LEU A 182 1 ? 10 HELX_P HELX_P7 7 ASN A 164 ? HIS A 176 ? ASN A 195 HIS A 207 1 ? 13 HELX_P HELX_P8 8 LEU A 199 ? GLY A 204 ? LEU A 230 GLY A 235 1 ? 6 HELX_P HELX_P9 9 THR A 206 ? ARG A 214 ? THR A 237 ARG A 245 1 ? 9 HELX_P HELX_P10 10 THR A 234 ? GLN A 239 ? THR A 265 GLN A 270 1 ? 6 HELX_P HELX_P11 11 VAL A 264 ? HIS A 289 ? VAL A 295 HIS A 320 1 ? 26 HELX_P HELX_P12 12 GLY A 293 ? ASP A 316 ? GLY A 324 ASP A 347 1 ? 24 HELX_P HELX_P13 13 ASP A 316 ? GLY A 323 ? ASP A 347 GLY A 354 1 ? 8 HELX_P HELX_P14 14 ASP A 331 ? PHE A 336 ? ASP A 362 PHE A 367 5 ? 6 HELX_P HELX_P15 15 ALA A 347 ? TYR A 354 ? ALA A 378 TYR A 385 1 ? 8 HELX_P HELX_P16 16 TRP A 356 ? LEU A 360 ? TRP A 387 LEU A 391 5 ? 5 HELX_P HELX_P17 17 SER A 372 ? LEU A 377 ? SER A 403 LEU A 408 1 ? 6 HELX_P HELX_P18 18 ASN A 380 ? GLY A 387 ? ASN A 411 GLY A 418 1 ? 8 HELX_P HELX_P19 19 GLY A 387 ? THR A 396 ? GLY A 418 THR A 427 1 ? 10 HELX_P HELX_P20 20 PRO A 410 ? ALA A 412 ? PRO A 441 ALA A 443 5 ? 3 HELX_P HELX_P21 21 VAL A 413 ? MET A 427 ? VAL A 444 MET A 458 1 ? 15 HELX_P HELX_P22 22 SER A 431 ? PHE A 439 ? SER A 462 PHE A 470 1 ? 9 HELX_P HELX_P23 23 SER A 446 ? GLY A 452 ? SER A 477 GLY A 483 1 ? 7 HELX_P HELX_P24 24 LYS A 454 ? SER A 465 ? LYS A 485 SER A 496 1 ? 12 HELX_P HELX_P25 25 ASP A 466 ? MET A 470 ? ASP A 497 MET A 501 5 ? 5 HELX_P HELX_P26 26 GLU A 471 ? GLU A 479 ? GLU A 502 GLU A 510 1 ? 9 HELX_P HELX_P27 27 GLY A 488 ? GLY A 505 ? GLY A 519 GLY A 536 1 ? 18 HELX_P HELX_P28 28 ASN A 506 ? SER A 510 ? ASN A 537 SER A 541 5 ? 5 HELX_P HELX_P29 29 LYS A 515 ? GLY A 520 ? LYS A 546 GLY A 551 5 ? 6 HELX_P HELX_P30 30 GLY A 521 ? THR A 530 ? GLY A 552 THR A 561 1 ? 10 HELX_P HELX_P31 31 SER A 532 ? VAL A 541 ? SER A 563 VAL A 572 1 ? 10 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 4 SG ? ? ? 1_555 A CYS 15 SG ? ? A CYS 36 A CYS 47 1_555 ? ? ? ? ? ? ? 2.035 ? disulf2 disulf ? ? A CYS 5 SG ? ? ? 1_555 A CYS 128 SG ? ? A CYS 37 A CYS 159 1_555 ? ? ? ? ? ? ? 2.032 ? disulf3 disulf ? ? A CYS 9 SG ? ? ? 1_555 A CYS 25 SG ? ? A CYS 41 A CYS 57 1_555 ? ? ? ? ? ? ? 2.031 ? disulf4 disulf ? ? A CYS 27 SG ? ? ? 1_555 A CYS 37 SG ? ? A CYS 59 A CYS 69 1_555 ? ? ? ? ? ? ? 2.039 ? disulf5 disulf ? ? A CYS 538 SG ? ? ? 1_555 A CYS 544 SG ? ? A CYS 569 A CYS 575 1_555 ? ? ? ? ? ? ? 2.034 ? covale1 covale ? ? A ASN 36 ND2 ? ? ? 1_555 E NAG . C1 ? ? A ASN 68 A NAG 704 1_555 ? ? ? ? ? ? ? 1.436 ? covale2 covale ? ? A ASN 113 ND2 ? ? ? 1_555 B NAG . C1 ? ? A ASN 144 A NAG 701 1_555 ? ? ? ? ? ? ? 1.437 ? covale3 covale ? ? B NAG . O4 ? ? ? 1_555 C NAG . C1 ? ? A NAG 701 A NAG 702 1_555 ? ? ? ? ? ? ? 1.441 ? covale4 covale ? ? A ASN 379 ND2 ? ? ? 1_555 F NAG . C1 ? ? A ASN 410 A NAG 705 1_555 ? ? ? ? ? ? ? 1.442 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? # _struct_mon_prot_cis.pdbx_id 1 _struct_mon_prot_cis.label_comp_id SER _struct_mon_prot_cis.label_seq_id 95 _struct_mon_prot_cis.label_asym_id A _struct_mon_prot_cis.label_alt_id . _struct_mon_prot_cis.pdbx_PDB_ins_code ? _struct_mon_prot_cis.auth_comp_id SER _struct_mon_prot_cis.auth_seq_id 126 _struct_mon_prot_cis.auth_asym_id A _struct_mon_prot_cis.pdbx_label_comp_id_2 PRO _struct_mon_prot_cis.pdbx_label_seq_id_2 96 _struct_mon_prot_cis.pdbx_label_asym_id_2 A _struct_mon_prot_cis.pdbx_PDB_ins_code_2 ? _struct_mon_prot_cis.pdbx_auth_comp_id_2 PRO _struct_mon_prot_cis.pdbx_auth_seq_id_2 127 _struct_mon_prot_cis.pdbx_auth_asym_id_2 A _struct_mon_prot_cis.pdbx_PDB_model_num 1 _struct_mon_prot_cis.pdbx_omega_angle 3.34 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 2 ? B ? 2 ? C ? 2 ? D ? 2 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? anti-parallel B 1 2 ? anti-parallel C 1 2 ? anti-parallel D 1 2 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 GLU A 14 ? SER A 17 ? GLU A 46 SER A 49 A 2 TYR A 23 ? ASP A 26 ? TYR A 55 ASP A 58 B 1 PHE A 32 ? TYR A 33 ? PHE A 64 TYR A 65 B 2 THR A 39 ? PRO A 40 ? THR A 71 PRO A 72 C 1 GLN A 224 ? ILE A 226 ? GLN A 255 ILE A 257 C 2 GLU A 229 ? TYR A 231 ? GLU A 260 TYR A 262 D 1 PHE A 364 ? ILE A 366 ? PHE A 395 ILE A 397 D 2 GLN A 369 ? TYR A 371 ? GLN A 400 TYR A 402 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 N GLU A 14 ? N GLU A 46 O ASP A 26 ? O ASP A 58 B 1 2 N TYR A 33 ? N TYR A 65 O THR A 39 ? O THR A 71 C 1 2 N GLN A 224 ? N GLN A 255 O TYR A 231 ? O TYR A 262 D 1 2 N PHE A 364 ? N PHE A 395 O TYR A 371 ? O TYR A 402 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 8 'BINDING SITE FOR RESIDUE NAG A 701' AC2 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE NAG A 702' AC3 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE BOG A 703' AC4 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE NAG A 704' AC5 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE NAG A 705' AC6 Software ? ? ? ? 8 'BINDING SITE FOR RESIDUE IBP A 706' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 8 GLU A 109 ? GLU A 140 . ? 1_555 ? 2 AC1 8 ASN A 113 ? ASN A 144 . ? 1_555 ? 3 AC1 8 TYR A 116 ? TYR A 147 . ? 1_555 ? 4 AC1 8 ARG A 185 ? ARG A 216 . ? 1_555 ? 5 AC1 8 PHE A 189 ? PHE A 220 . ? 1_555 ? 6 AC1 8 LEU A 207 ? LEU A 238 . ? 6_544 ? 7 AC1 8 NAG C . ? NAG A 702 . ? 1_555 ? 8 AC1 8 HOH H . ? HOH A 867 . ? 1_555 ? 9 AC2 3 ARG A 185 ? ARG A 216 . ? 1_555 ? 10 AC2 3 ASP A 208 ? ASP A 239 . ? 6_544 ? 11 AC2 3 NAG B . ? NAG A 701 . ? 1_555 ? 12 AC3 4 PRO A 52 ? PRO A 84 . ? 1_555 ? 13 AC3 4 SER A 88 ? SER A 119 . ? 1_555 ? 14 AC3 4 ARG A 89 ? ARG A 120 . ? 1_555 ? 15 AC3 4 HOH H . ? HOH A 896 . ? 1_555 ? 16 AC4 3 TYR A 23 ? TYR A 55 . ? 1_555 ? 17 AC4 3 GLU A 35 ? GLU A 67 . ? 1_555 ? 18 AC4 3 ASN A 36 ? ASN A 68 . ? 1_555 ? 19 AC5 5 GLN A 375 ? GLN A 406 . ? 1_555 ? 20 AC5 5 ASN A 379 ? ASN A 410 . ? 1_555 ? 21 AC5 5 SER A 381 ? SER A 412 . ? 1_555 ? 22 AC5 5 ILE A 382 ? ILE A 413 . ? 1_555 ? 23 AC5 5 GLU A 385 ? GLU A 416 . ? 1_555 ? 24 AC6 8 ARG A 89 ? ARG A 120 . ? 1_555 ? 25 AC6 8 VAL A 318 ? VAL A 349 . ? 1_555 ? 26 AC6 8 LEU A 321 ? LEU A 352 . ? 1_555 ? 27 AC6 8 TYR A 324 ? TYR A 355 . ? 1_555 ? 28 AC6 8 MET A 491 ? MET A 522 . ? 1_555 ? 29 AC6 8 GLY A 495 ? GLY A 526 . ? 1_555 ? 30 AC6 8 ALA A 496 ? ALA A 527 . ? 1_555 ? 31 AC6 8 LEU A 500 ? LEU A 531 . ? 1_555 ? # _database_PDB_matrix.entry_id 4RS0 _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 4RS0 _atom_sites.fract_transf_matrix[1][1] 0.005773 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.005773 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.004893 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . ALA A 1 1 ? -7.689 -37.950 -41.177 1.00 54.65 ? 33 ALA A N 1 ATOM 2 C CA . ALA A 1 1 ? -7.506 -39.369 -40.897 1.00 74.81 ? 33 ALA A CA 1 ATOM 3 C C . ALA A 1 1 ? -6.411 -39.961 -41.778 1.00 65.06 ? 33 ALA A C 1 ATOM 4 O O . ALA A 1 1 ? -5.434 -40.518 -41.275 1.00 60.64 ? 33 ALA A O 1 ATOM 5 C CB . ALA A 1 1 ? -8.813 -40.122 -41.094 1.00 64.85 ? 33 ALA A CB 1 ATOM 6 N N . ASN A 1 2 ? -6.589 -39.838 -43.091 1.00 63.43 ? 34 ASN A N 1 ATOM 7 C CA . ASN A 1 2 ? -5.624 -40.327 -44.070 1.00 53.64 ? 34 ASN A CA 1 ATOM 8 C C . ASN A 1 2 ? -4.223 -39.792 -43.780 1.00 55.37 ? 34 ASN A C 1 ATOM 9 O O . ASN A 1 2 ? -4.002 -38.582 -43.798 1.00 56.84 ? 34 ASN A O 1 ATOM 10 C CB . ASN A 1 2 ? -6.066 -39.931 -45.482 1.00 56.97 ? 34 ASN A CB 1 ATOM 11 C CG . ASN A 1 2 ? -5.372 -40.733 -46.571 1.00 66.32 ? 34 ASN A CG 1 ATOM 12 O OD1 . ASN A 1 2 ? -4.191 -41.071 -46.465 1.00 60.19 ? 34 ASN A OD1 1 ATOM 13 N ND2 . ASN A 1 2 ? -6.109 -41.035 -47.633 1.00 61.01 ? 34 ASN A ND2 1 ATOM 14 N N . PRO A 1 3 ? -3.271 -40.698 -43.505 1.00 55.69 ? 35 PRO A N 1 ATOM 15 C CA . PRO A 1 3 ? -1.905 -40.319 -43.123 1.00 48.69 ? 35 PRO A CA 1 ATOM 16 C C . PRO A 1 3 ? -1.119 -39.634 -44.237 1.00 47.13 ? 35 PRO A C 1 ATOM 17 O O . PRO A 1 3 ? -0.006 -39.176 -43.989 1.00 52.88 ? 35 PRO A O 1 ATOM 18 C CB . PRO A 1 3 ? -1.258 -41.661 -42.760 1.00 52.84 ? 35 PRO A CB 1 ATOM 19 C CG . PRO A 1 3 ? -2.040 -42.672 -43.517 1.00 53.18 ? 35 PRO A CG 1 ATOM 20 C CD . PRO A 1 3 ? -3.449 -42.160 -43.535 1.00 54.97 ? 35 PRO A CD 1 ATOM 21 N N . CYS A 1 4 ? -1.685 -39.568 -45.439 1.00 51.92 ? 36 CYS A N 1 ATOM 22 C CA . CYS A 1 4 ? -1.024 -38.913 -46.563 1.00 48.48 ? 36 CYS A CA 1 ATOM 23 C C . CYS A 1 4 ? -1.540 -37.492 -46.784 1.00 51.64 ? 36 CYS A C 1 ATOM 24 O O . CYS A 1 4 ? -1.118 -36.813 -47.721 1.00 50.34 ? 36 CYS A O 1 ATOM 25 C CB . CYS A 1 4 ? -1.208 -39.732 -47.842 1.00 42.66 ? 36 CYS A CB 1 ATOM 26 S SG . CYS A 1 4 ? -0.254 -41.267 -47.903 1.00 57.34 ? 36 CYS A SG 1 ATOM 27 N N . CYS A 1 5 ? -2.447 -37.046 -45.919 1.00 49.42 ? 37 CYS A N 1 ATOM 28 C CA . CYS A 1 5 ? -3.087 -35.741 -46.073 1.00 44.00 ? 37 CYS A CA 1 ATOM 29 C C . CYS A 1 5 ? -2.105 -34.575 -46.004 1.00 45.75 ? 37 CYS A C 1 ATOM 30 O O . CYS A 1 5 ? -2.342 -33.522 -46.592 1.00 52.32 ? 37 CYS A O 1 ATOM 31 C CB . CYS A 1 5 ? -4.173 -35.552 -45.011 1.00 42.09 ? 37 CYS A CB 1 ATOM 32 S SG . CYS A 1 5 ? -5.727 -36.397 -45.369 1.00 58.67 ? 37 CYS A SG 1 ATOM 33 N N . SER A 1 6 ? -1.003 -34.765 -45.288 1.00 46.83 ? 38 SER A N 1 ATOM 34 C CA . SER A 1 6 ? -0.021 -33.702 -45.112 1.00 49.07 ? 38 SER A CA 1 ATOM 35 C C . SER A 1 6 ? 0.893 -33.560 -46.326 1.00 48.03 ? 38 SER A C 1 ATOM 36 O O . SER A 1 6 ? 1.760 -32.685 -46.354 1.00 51.86 ? 38 SER A O 1 ATOM 37 C CB . SER A 1 6 ? 0.819 -33.958 -43.859 1.00 45.71 ? 38 SER A CB 1 ATOM 38 O OG . SER A 1 6 ? 1.603 -35.130 -44.004 1.00 43.66 ? 38 SER A OG 1 ATOM 39 N N . ASN A 1 7 ? 0.685 -34.419 -47.322 1.00 44.85 ? 39 ASN A N 1 ATOM 40 C CA . ASN A 1 7 ? 1.553 -34.495 -48.498 1.00 37.26 ? 39 ASN A CA 1 ATOM 41 C C . ASN A 1 7 ? 3.025 -34.619 -48.111 1.00 42.75 ? 39 ASN A C 1 ATOM 42 O O . ASN A 1 7 ? 3.831 -33.748 -48.442 1.00 54.97 ? 39 ASN A O 1 ATOM 43 C CB . ASN A 1 7 ? 1.351 -33.271 -49.395 1.00 35.36 ? 39 ASN A CB 1 ATOM 44 C CG . ASN A 1 7 ? -0.100 -33.065 -49.783 1.00 46.63 ? 39 ASN A CG 1 ATOM 45 O OD1 . ASN A 1 7 ? -0.784 -34.002 -50.194 1.00 49.97 ? 39 ASN A OD1 1 ATOM 46 N ND2 . ASN A 1 7 ? -0.581 -31.833 -49.645 1.00 48.35 ? 39 ASN A ND2 1 ATOM 47 N N . PRO A 1 8 ? 3.382 -35.709 -47.412 1.00 42.69 ? 40 PRO A N 1 ATOM 48 C CA . PRO A 1 8 ? 4.726 -35.837 -46.840 1.00 41.71 ? 40 PRO A CA 1 ATOM 49 C C . PRO A 1 8 ? 5.813 -36.141 -47.869 1.00 42.65 ? 40 PRO A C 1 ATOM 50 O O . PRO A 1 8 ? 6.971 -35.785 -47.651 1.00 43.05 ? 40 PRO A O 1 ATOM 51 C CB . PRO A 1 8 ? 4.571 -37.004 -45.863 1.00 42.46 ? 40 PRO A CB 1 ATOM 52 C CG . PRO A 1 8 ? 3.509 -37.849 -46.471 1.00 42.30 ? 40 PRO A CG 1 ATOM 53 C CD . PRO A 1 8 ? 2.557 -36.905 -47.156 1.00 42.88 ? 40 PRO A CD 1 ATOM 54 N N . CYS A 1 9 ? 5.447 -36.788 -48.969 1.00 42.92 ? 41 CYS A N 1 ATOM 55 C CA . CYS A 1 9 ? 6.434 -37.231 -49.948 1.00 39.85 ? 41 CYS A CA 1 ATOM 56 C C . CYS A 1 9 ? 6.897 -36.097 -50.854 1.00 43.89 ? 41 CYS A C 1 ATOM 57 O O . CYS A 1 9 ? 6.085 -35.373 -51.429 1.00 46.89 ? 41 CYS A O 1 ATOM 58 C CB . CYS A 1 9 ? 5.868 -38.371 -50.788 1.00 37.19 ? 41 CYS A CB 1 ATOM 59 S SG . CYS A 1 9 ? 5.443 -39.826 -49.812 1.00 52.87 ? 41 CYS A SG 1 ATOM 60 N N . GLN A 1 10 ? 8.212 -35.956 -50.980 1.00 41.68 ? 42 GLN A N 1 ATOM 61 C CA . GLN A 1 10 ? 8.803 -34.881 -51.764 1.00 39.45 ? 42 GLN A CA 1 ATOM 62 C C . GLN A 1 10 ? 9.421 -35.409 -53.054 1.00 40.74 ? 42 GLN A C 1 ATOM 63 O O . GLN A 1 10 ? 9.586 -36.616 -53.223 1.00 39.55 ? 42 GLN A O 1 ATOM 64 C CB . GLN A 1 10 ? 9.862 -34.143 -50.938 1.00 40.21 ? 42 GLN A CB 1 ATOM 65 C CG . GLN A 1 10 ? 9.373 -33.670 -49.579 1.00 27.31 ? 42 GLN A CG 1 ATOM 66 C CD . GLN A 1 10 ? 8.261 -32.649 -49.684 1.00 34.64 ? 42 GLN A CD 1 ATOM 67 O OE1 . GLN A 1 10 ? 8.479 -31.521 -50.125 1.00 44.77 ? 42 GLN A OE1 1 ATOM 68 N NE2 . GLN A 1 10 ? 7.058 -33.042 -49.282 1.00 37.25 ? 42 GLN A NE2 1 ATOM 69 N N . ASN A 1 11 ? 9.752 -34.488 -53.956 1.00 41.93 ? 43 ASN A N 1 ATOM 70 C CA . ASN A 1 11 ? 10.421 -34.804 -55.219 1.00 34.86 ? 43 ASN A CA 1 ATOM 71 C C . ASN A 1 11 ? 9.699 -35.867 -56.043 1.00 34.04 ? 43 ASN A C 1 ATOM 72 O O . ASN A 1 11 ? 10.326 -36.771 -56.599 1.00 39.40 ? 43 ASN A O 1 ATOM 73 C CB . ASN A 1 11 ? 11.863 -35.234 -54.954 1.00 35.01 ? 43 ASN A CB 1 ATOM 74 C CG . ASN A 1 11 ? 12.658 -34.171 -54.218 1.00 45.44 ? 43 ASN A CG 1 ATOM 75 O OD1 . ASN A 1 11 ? 13.011 -33.140 -54.789 1.00 49.97 ? 43 ASN A OD1 1 ATOM 76 N ND2 . ASN A 1 11 ? 12.940 -34.417 -52.943 1.00 44.80 ? 43 ASN A ND2 1 ATOM 77 N N . ARG A 1 12 ? 8.375 -35.742 -56.102 1.00 37.63 ? 44 ARG A N 1 ATOM 78 C CA . ARG A 1 12 ? 7.513 -36.588 -56.927 1.00 40.70 ? 44 ARG A CA 1 ATOM 79 C C . ARG A 1 12 ? 7.494 -38.055 -56.501 1.00 43.63 ? 44 ARG A C 1 ATOM 80 O O . ARG A 1 12 ? 7.150 -38.931 -57.295 1.00 38.76 ? 44 ARG A O 1 ATOM 81 C CB . ARG A 1 12 ? 7.921 -36.482 -58.398 1.00 26.95 ? 44 ARG A CB 1 ATOM 82 C CG . ARG A 1 12 ? 7.886 -35.067 -58.943 1.00 35.25 ? 44 ARG A CG 1 ATOM 83 C CD . ARG A 1 12 ? 7.885 -35.072 -60.457 1.00 45.95 ? 44 ARG A CD 1 ATOM 84 N NE . ARG A 1 12 ? 6.719 -35.778 -60.974 1.00 44.38 ? 44 ARG A NE 1 ATOM 85 C CZ . ARG A 1 12 ? 6.536 -36.071 -62.258 1.00 63.94 ? 44 ARG A CZ 1 ATOM 86 N NH1 . ARG A 1 12 ? 7.447 -35.723 -63.167 1.00 35.91 ? 44 ARG A NH1 1 ATOM 87 N NH2 . ARG A 1 12 ? 5.442 -36.719 -62.637 1.00 52.74 ? 44 ARG A NH2 1 ATOM 88 N N . GLY A 1 13 ? 7.860 -38.321 -55.252 1.00 37.13 ? 45 GLY A N 1 ATOM 89 C CA . GLY A 1 13 ? 7.676 -39.642 -54.681 1.00 35.42 ? 45 GLY A CA 1 ATOM 90 C C . GLY A 1 13 ? 6.198 -39.840 -54.399 1.00 39.63 ? 45 GLY A C 1 ATOM 91 O O . GLY A 1 13 ? 5.485 -38.874 -54.120 1.00 36.22 ? 45 GLY A O 1 ATOM 92 N N . GLU A 1 14 ? 5.728 -41.081 -54.471 1.00 42.19 ? 46 GLU A N 1 ATOM 93 C CA . GLU A 1 14 ? 4.305 -41.351 -54.301 1.00 37.97 ? 46 GLU A CA 1 ATOM 94 C C . GLU A 1 14 ? 3.986 -41.830 -52.890 1.00 39.93 ? 46 GLU A C 1 ATOM 95 O O . GLU A 1 14 ? 4.674 -42.692 -52.343 1.00 38.72 ? 46 GLU A O 1 ATOM 96 C CB . GLU A 1 14 ? 3.836 -42.374 -55.332 1.00 38.39 ? 46 GLU A CB 1 ATOM 97 C CG . GLU A 1 14 ? 4.172 -41.972 -56.760 1.00 52.71 ? 46 GLU A CG 1 ATOM 98 C CD . GLU A 1 14 ? 3.553 -42.890 -57.789 1.00 69.96 ? 46 GLU A CD 1 ATOM 99 O OE1 . GLU A 1 14 ? 2.711 -43.733 -57.409 1.00 68.66 ? 46 GLU A OE1 1 ATOM 100 O OE2 . GLU A 1 14 ? 3.908 -42.769 -58.980 1.00 71.37 ? 46 GLU A OE2 1 ATOM 101 N N . CYS A 1 15 ? 2.933 -41.263 -52.309 1.00 40.39 ? 47 CYS A N 1 ATOM 102 C CA . CYS A 1 15 ? 2.543 -41.583 -50.941 1.00 37.93 ? 47 CYS A CA 1 ATOM 103 C C . CYS A 1 15 ? 1.501 -42.693 -50.892 1.00 40.66 ? 47 CYS A C 1 ATOM 104 O O . CYS A 1 15 ? 0.508 -42.665 -51.619 1.00 43.20 ? 47 CYS A O 1 ATOM 105 C CB . CYS A 1 15 ? 2.004 -40.339 -50.233 1.00 40.90 ? 47 CYS A CB 1 ATOM 106 S SG . CYS A 1 15 ? 1.578 -40.606 -48.494 1.00 48.94 ? 47 CYS A SG 1 ATOM 107 N N . MET A 1 16 ? 1.737 -43.666 -50.021 1.00 43.77 ? 48 MET A N 1 ATOM 108 C CA . MET A 1 16 ? 0.810 -44.771 -49.823 1.00 40.24 ? 48 MET A CA 1 ATOM 109 C C . MET A 1 16 ? 0.620 -45.028 -48.335 1.00 41.64 ? 48 MET A C 1 ATOM 110 O O . MET A 1 16 ? 1.591 -45.082 -47.581 1.00 45.15 ? 48 MET A O 1 ATOM 111 C CB . MET A 1 16 ? 1.321 -46.032 -50.520 1.00 32.38 ? 48 MET A CB 1 ATOM 112 C CG . MET A 1 16 ? 0.429 -47.249 -50.354 1.00 31.71 ? 48 MET A CG 1 ATOM 113 S SD . MET A 1 16 ? 1.209 -48.758 -50.963 1.00 43.45 ? 48 MET A SD 1 ATOM 114 C CE . MET A 1 16 ? 2.564 -48.940 -49.800 1.00 37.49 ? 48 MET A CE 1 ATOM 115 N N . SER A 1 17 ? -0.629 -45.180 -47.912 1.00 34.79 ? 49 SER A N 1 ATOM 116 C CA . SER A 1 17 ? -0.913 -45.484 -46.517 1.00 39.69 ? 49 SER A CA 1 ATOM 117 C C . SER A 1 17 ? -0.608 -46.948 -46.218 1.00 45.03 ? 49 SER A C 1 ATOM 118 O O . SER A 1 17 ? -0.918 -47.831 -47.017 1.00 43.72 ? 49 SER A O 1 ATOM 119 C CB . SER A 1 17 ? -2.369 -45.161 -46.175 1.00 31.68 ? 49 SER A CB 1 ATOM 120 O OG . SER A 1 17 ? -3.267 -45.923 -46.961 1.00 34.28 ? 49 SER A OG 1 ATOM 121 N N . THR A 1 18 ? 0.016 -47.196 -45.072 1.00 45.23 ? 50 THR A N 1 ATOM 122 C CA . THR A 1 18 ? 0.338 -48.554 -44.649 1.00 44.14 ? 50 THR A CA 1 ATOM 123 C C . THR A 1 18 ? -0.239 -48.808 -43.265 1.00 44.91 ? 50 THR A C 1 ATOM 124 O O . THR A 1 18 ? 0.486 -49.136 -42.327 1.00 63.31 ? 50 THR A O 1 ATOM 125 C CB . THR A 1 18 ? 1.857 -48.802 -44.628 1.00 41.11 ? 50 THR A CB 1 ATOM 126 O OG1 . THR A 1 18 ? 2.479 -47.910 -43.695 1.00 48.22 ? 50 THR A OG1 1 ATOM 127 C CG2 . THR A 1 18 ? 2.451 -48.579 -46.008 1.00 42.68 ? 50 THR A CG2 1 ATOM 128 N N . GLY A 1 19 ? -1.552 -48.654 -43.150 1.00 40.81 ? 51 GLY A N 1 ATOM 129 C CA . GLY A 1 19 ? -2.223 -48.701 -41.866 1.00 44.96 ? 51 GLY A CA 1 ATOM 130 C C . GLY A 1 19 ? -3.053 -47.445 -41.692 1.00 47.91 ? 51 GLY A C 1 ATOM 131 O O . GLY A 1 19 ? -3.140 -46.628 -42.608 1.00 49.78 ? 51 GLY A O 1 ATOM 132 N N . PHE A 1 20 ? -3.660 -47.281 -40.522 1.00 50.28 ? 52 PHE A N 1 ATOM 133 C CA . PHE A 1 20 ? -4.522 -46.130 -40.278 1.00 52.49 ? 52 PHE A CA 1 ATOM 134 C C . PHE A 1 20 ? -3.732 -44.855 -39.985 1.00 61.78 ? 52 PHE A C 1 ATOM 135 O O . PHE A 1 20 ? -4.184 -43.755 -40.312 1.00 62.61 ? 52 PHE A O 1 ATOM 136 C CB . PHE A 1 20 ? -5.484 -46.418 -39.125 1.00 45.61 ? 52 PHE A CB 1 ATOM 137 C CG . PHE A 1 20 ? -6.600 -47.357 -39.487 1.00 42.04 ? 52 PHE A CG 1 ATOM 138 C CD1 . PHE A 1 20 ? -7.746 -46.884 -40.108 1.00 35.97 ? 52 PHE A CD1 1 ATOM 139 C CD2 . PHE A 1 20 ? -6.507 -48.710 -39.202 1.00 36.23 ? 52 PHE A CD2 1 ATOM 140 C CE1 . PHE A 1 20 ? -8.777 -47.744 -40.443 1.00 34.87 ? 52 PHE A CE1 1 ATOM 141 C CE2 . PHE A 1 20 ? -7.535 -49.576 -39.533 1.00 36.63 ? 52 PHE A CE2 1 ATOM 142 C CZ . PHE A 1 20 ? -8.672 -49.093 -40.154 1.00 36.49 ? 52 PHE A CZ 1 ATOM 143 N N . ASP A 1 21 ? -2.558 -44.998 -39.377 1.00 54.83 ? 53 ASP A N 1 ATOM 144 C CA . ASP A 1 21 ? -1.769 -43.834 -38.981 1.00 60.47 ? 53 ASP A CA 1 ATOM 145 C C . ASP A 1 21 ? -0.324 -43.889 -39.464 1.00 55.55 ? 53 ASP A C 1 ATOM 146 O O . ASP A 1 21 ? 0.549 -43.242 -38.890 1.00 58.36 ? 53 ASP A O 1 ATOM 147 C CB . ASP A 1 21 ? -1.792 -43.675 -37.458 1.00 75.97 ? 53 ASP A CB 1 ATOM 148 C CG . ASP A 1 21 ? -3.044 -42.976 -36.963 1.00 92.71 ? 53 ASP A CG 1 ATOM 149 O OD1 . ASP A 1 21 ? -3.027 -41.731 -36.860 1.00 84.42 ? 53 ASP A OD1 1 ATOM 150 O OD2 . ASP A 1 21 ? -4.041 -43.671 -36.675 1.00 89.66 ? 53 ASP A OD2 1 ATOM 151 N N . GLN A 1 22 ? -0.071 -44.654 -40.520 1.00 58.60 ? 54 GLN A N 1 ATOM 152 C CA . GLN A 1 22 ? 1.275 -44.746 -41.080 1.00 57.77 ? 54 GLN A CA 1 ATOM 153 C C . GLN A 1 22 ? 1.271 -44.654 -42.603 1.00 53.32 ? 54 GLN A C 1 ATOM 154 O O . GLN A 1 22 ? 0.289 -45.013 -43.256 1.00 47.55 ? 54 GLN A O 1 ATOM 155 C CB . GLN A 1 22 ? 1.951 -46.048 -40.643 1.00 59.57 ? 54 GLN A CB 1 ATOM 156 C CG . GLN A 1 22 ? 2.433 -46.050 -39.202 1.00 69.17 ? 54 GLN A CG 1 ATOM 157 C CD . GLN A 1 22 ? 3.113 -47.351 -38.820 1.00 99.46 ? 54 GLN A CD 1 ATOM 158 O OE1 . GLN A 1 22 ? 3.004 -48.352 -39.528 1.00 89.15 ? 54 GLN A OE1 1 ATOM 159 N NE2 . GLN A 1 22 ? 3.825 -47.341 -37.698 1.00 98.45 ? 54 GLN A NE2 1 ATOM 160 N N . TYR A 1 23 ? 2.375 -44.169 -43.162 1.00 50.25 ? 55 TYR A N 1 ATOM 161 C CA . TYR A 1 23 ? 2.522 -44.078 -44.609 1.00 41.48 ? 55 TYR A CA 1 ATOM 162 C C . TYR A 1 23 ? 3.893 -44.571 -45.052 1.00 43.05 ? 55 TYR A C 1 ATOM 163 O O . TYR A 1 23 ? 4.794 -44.759 -44.232 1.00 46.99 ? 55 TYR A O 1 ATOM 164 C CB . TYR A 1 23 ? 2.304 -42.638 -45.089 1.00 44.61 ? 55 TYR A CB 1 ATOM 165 C CG . TYR A 1 23 ? 3.355 -41.646 -44.625 1.00 44.40 ? 55 TYR A CG 1 ATOM 166 C CD1 . TYR A 1 23 ? 4.527 -41.449 -45.350 1.00 40.97 ? 55 TYR A CD1 1 ATOM 167 C CD2 . TYR A 1 23 ? 3.168 -40.895 -43.470 1.00 47.77 ? 55 TYR A CD2 1 ATOM 168 C CE1 . TYR A 1 23 ? 5.488 -40.544 -44.930 1.00 43.90 ? 55 TYR A CE1 1 ATOM 169 C CE2 . TYR A 1 23 ? 4.123 -39.986 -43.044 1.00 38.77 ? 55 TYR A CE2 1 ATOM 170 C CZ . TYR A 1 23 ? 5.280 -39.815 -43.778 1.00 46.16 ? 55 TYR A CZ 1 ATOM 171 O OH . TYR A 1 23 ? 6.231 -38.913 -43.359 1.00 50.06 ? 55 TYR A OH 1 ATOM 172 N N . LYS A 1 24 ? 4.042 -44.777 -46.356 1.00 43.98 ? 56 LYS A N 1 ATOM 173 C CA . LYS A 1 24 ? 5.335 -45.097 -46.948 1.00 39.19 ? 56 LYS A CA 1 ATOM 174 C C . LYS A 1 24 ? 5.472 -44.370 -48.283 1.00 45.73 ? 56 LYS A C 1 ATOM 175 O O . LYS A 1 24 ? 4.502 -44.248 -49.033 1.00 45.42 ? 56 LYS A O 1 ATOM 176 C CB . LYS A 1 24 ? 5.494 -46.609 -47.130 1.00 38.40 ? 56 LYS A CB 1 ATOM 177 C CG . LYS A 1 24 ? 6.759 -47.015 -47.874 1.00 46.56 ? 56 LYS A CG 1 ATOM 178 C CD . LYS A 1 24 ? 6.961 -48.521 -47.866 1.00 58.43 ? 56 LYS A CD 1 ATOM 179 C CE . LYS A 1 24 ? 8.067 -48.929 -48.831 1.00 72.55 ? 56 LYS A CE 1 ATOM 180 N NZ . LYS A 1 24 ? 9.339 -48.190 -48.589 1.00 66.27 ? 56 LYS A NZ 1 ATOM 181 N N . CYS A 1 25 ? 6.672 -43.873 -48.569 1.00 41.35 ? 57 CYS A N 1 ATOM 182 C CA . CYS A 1 25 ? 6.921 -43.149 -49.810 1.00 36.60 ? 57 CYS A CA 1 ATOM 183 C C . CYS A 1 25 ? 7.652 -44.014 -50.830 1.00 43.55 ? 57 CYS A C 1 ATOM 184 O O . CYS A 1 25 ? 8.689 -44.604 -50.528 1.00 51.56 ? 57 CYS A O 1 ATOM 185 C CB . CYS A 1 25 ? 7.726 -41.876 -49.539 1.00 36.72 ? 57 CYS A CB 1 ATOM 186 S SG . CYS A 1 25 ? 6.844 -40.626 -48.578 1.00 41.76 ? 57 CYS A SG 1 ATOM 187 N N . ASP A 1 26 ? 7.103 -44.085 -52.038 1.00 46.20 ? 58 ASP A N 1 ATOM 188 C CA . ASP A 1 26 ? 7.756 -44.782 -53.139 1.00 36.57 ? 58 ASP A CA 1 ATOM 189 C C . ASP A 1 26 ? 8.694 -43.819 -53.861 1.00 37.62 ? 58 ASP A C 1 ATOM 190 O O . ASP A 1 26 ? 8.246 -42.935 -54.592 1.00 45.31 ? 58 ASP A O 1 ATOM 191 C CB . ASP A 1 26 ? 6.720 -45.354 -54.109 1.00 33.07 ? 58 ASP A CB 1 ATOM 192 C CG . ASP A 1 26 ? 7.303 -46.399 -55.042 1.00 41.49 ? 58 ASP A CG 1 ATOM 193 O OD1 . ASP A 1 26 ? 8.531 -46.382 -55.273 1.00 38.50 ? 58 ASP A OD1 1 ATOM 194 O OD2 . ASP A 1 26 ? 6.529 -47.240 -55.547 1.00 44.93 ? 58 ASP A OD2 1 ATOM 195 N N . CYS A 1 27 ? 9.995 -43.996 -53.654 1.00 33.16 ? 59 CYS A N 1 ATOM 196 C CA . CYS A 1 27 ? 10.991 -43.074 -54.190 1.00 36.67 ? 59 CYS A CA 1 ATOM 197 C C . CYS A 1 27 ? 11.607 -43.571 -55.496 1.00 40.65 ? 59 CYS A C 1 ATOM 198 O O . CYS A 1 27 ? 12.674 -43.107 -55.900 1.00 42.48 ? 59 CYS A O 1 ATOM 199 C CB . CYS A 1 27 ? 12.095 -42.836 -53.156 1.00 36.50 ? 59 CYS A CB 1 ATOM 200 S SG . CYS A 1 27 ? 11.503 -42.232 -51.554 1.00 61.31 ? 59 CYS A SG 1 ATOM 201 N N . THR A 1 28 ? 10.929 -44.508 -56.152 1.00 38.65 ? 60 THR A N 1 ATOM 202 C CA . THR A 1 28 ? 11.440 -45.117 -57.376 1.00 31.79 ? 60 THR A CA 1 ATOM 203 C C . THR A 1 28 ? 11.696 -44.087 -58.476 1.00 37.76 ? 60 THR A C 1 ATOM 204 O O . THR A 1 28 ? 10.798 -43.331 -58.852 1.00 41.47 ? 60 THR A O 1 ATOM 205 C CB . THR A 1 28 ? 10.470 -46.183 -57.912 1.00 35.17 ? 60 THR A CB 1 ATOM 206 O OG1 . THR A 1 28 ? 10.254 -47.183 -56.910 1.00 35.66 ? 60 THR A OG1 1 ATOM 207 C CG2 . THR A 1 28 ? 11.034 -46.840 -59.161 1.00 31.85 ? 60 THR A CG2 1 ATOM 208 N N . ARG A 1 29 ? 12.933 -44.063 -58.969 1.00 41.14 ? 61 ARG A N 1 ATOM 209 C CA . ARG A 1 29 ? 13.353 -43.193 -60.072 1.00 38.54 ? 61 ARG A CA 1 ATOM 210 C C . ARG A 1 29 ? 13.116 -41.700 -59.823 1.00 35.80 ? 61 ARG A C 1 ATOM 211 O O . ARG A 1 29 ? 12.995 -40.922 -60.769 1.00 40.17 ? 61 ARG A O 1 ATOM 212 C CB . ARG A 1 29 ? 12.654 -43.612 -61.370 1.00 22.69 ? 61 ARG A CB 1 ATOM 213 C CG . ARG A 1 29 ? 13.197 -44.897 -61.980 1.00 31.71 ? 61 ARG A CG 1 ATOM 214 C CD . ARG A 1 29 ? 12.445 -45.285 -63.244 1.00 26.19 ? 61 ARG A CD 1 ATOM 215 N NE . ARG A 1 29 ? 11.053 -45.630 -62.968 1.00 35.95 ? 61 ARG A NE 1 ATOM 216 C CZ . ARG A 1 29 ? 10.643 -46.841 -62.606 1.00 31.85 ? 61 ARG A CZ 1 ATOM 217 N NH1 . ARG A 1 29 ? 11.518 -47.827 -62.469 1.00 33.78 ? 61 ARG A NH1 1 ATOM 218 N NH2 . ARG A 1 29 ? 9.357 -47.065 -62.373 1.00 33.14 ? 61 ARG A NH2 1 ATOM 219 N N . THR A 1 30 ? 13.061 -41.302 -58.556 1.00 33.75 ? 62 THR A N 1 ATOM 220 C CA . THR A 1 30 ? 12.908 -39.892 -58.211 1.00 33.34 ? 62 THR A CA 1 ATOM 221 C C . THR A 1 30 ? 14.266 -39.213 -58.084 1.00 39.97 ? 62 THR A C 1 ATOM 222 O O . THR A 1 30 ? 14.371 -37.991 -58.184 1.00 45.63 ? 62 THR A O 1 ATOM 223 C CB . THR A 1 30 ? 12.135 -39.702 -56.890 1.00 36.55 ? 62 THR A CB 1 ATOM 224 O OG1 . THR A 1 30 ? 12.881 -40.275 -55.808 1.00 37.69 ? 62 THR A OG1 1 ATOM 225 C CG2 . THR A 1 30 ? 10.767 -40.359 -56.966 1.00 40.97 ? 62 THR A CG2 1 ATOM 226 N N . GLY A 1 31 ? 15.303 -40.014 -57.862 1.00 39.23 ? 63 GLY A N 1 ATOM 227 C CA . GLY A 1 31 ? 16.640 -39.493 -57.649 1.00 37.15 ? 63 GLY A CA 1 ATOM 228 C C . GLY A 1 31 ? 16.934 -39.282 -56.176 1.00 42.87 ? 63 GLY A C 1 ATOM 229 O O . GLY A 1 31 ? 18.030 -38.868 -55.802 1.00 46.27 ? 63 GLY A O 1 ATOM 230 N N . PHE A 1 32 ? 15.945 -39.571 -55.337 1.00 44.87 ? 64 PHE A N 1 ATOM 231 C CA . PHE A 1 32 ? 16.077 -39.407 -53.894 1.00 42.56 ? 64 PHE A CA 1 ATOM 232 C C . PHE A 1 32 ? 15.724 -40.690 -53.151 1.00 47.26 ? 64 PHE A C 1 ATOM 233 O O . PHE A 1 32 ? 15.088 -41.587 -53.706 1.00 49.14 ? 64 PHE A O 1 ATOM 234 C CB . PHE A 1 32 ? 15.179 -38.270 -53.393 1.00 41.73 ? 64 PHE A CB 1 ATOM 235 C CG . PHE A 1 32 ? 15.547 -36.915 -53.927 1.00 48.24 ? 64 PHE A CG 1 ATOM 236 C CD1 . PHE A 1 32 ? 15.180 -36.534 -55.207 1.00 45.35 ? 64 PHE A CD1 1 ATOM 237 C CD2 . PHE A 1 32 ? 16.242 -36.012 -53.139 1.00 48.33 ? 64 PHE A CD2 1 ATOM 238 C CE1 . PHE A 1 32 ? 15.513 -35.283 -55.697 1.00 40.54 ? 64 PHE A CE1 1 ATOM 239 C CE2 . PHE A 1 32 ? 16.577 -34.760 -53.623 1.00 46.32 ? 64 PHE A CE2 1 ATOM 240 C CZ . PHE A 1 32 ? 16.211 -34.396 -54.904 1.00 38.04 ? 64 PHE A CZ 1 ATOM 241 N N . TYR A 1 33 ? 16.138 -40.768 -51.891 1.00 45.84 ? 65 TYR A N 1 ATOM 242 C CA . TYR A 1 33 ? 15.701 -41.842 -51.010 1.00 44.49 ? 65 TYR A CA 1 ATOM 243 C C . TYR A 1 33 ? 15.472 -41.298 -49.605 1.00 48.37 ? 65 TYR A C 1 ATOM 244 O O . TYR A 1 33 ? 15.631 -40.103 -49.361 1.00 51.52 ? 65 TYR A O 1 ATOM 245 C CB . TYR A 1 33 ? 16.713 -42.993 -50.991 1.00 39.18 ? 65 TYR A CB 1 ATOM 246 C CG . TYR A 1 33 ? 18.113 -42.615 -50.560 1.00 41.99 ? 65 TYR A CG 1 ATOM 247 C CD1 . TYR A 1 33 ? 19.052 -42.177 -51.486 1.00 46.24 ? 65 TYR A CD1 1 ATOM 248 C CD2 . TYR A 1 33 ? 18.506 -42.721 -49.231 1.00 47.44 ? 65 TYR A CD2 1 ATOM 249 C CE1 . TYR A 1 33 ? 20.338 -41.840 -51.100 1.00 52.51 ? 65 TYR A CE1 1 ATOM 250 C CE2 . TYR A 1 33 ? 19.791 -42.387 -48.835 1.00 47.01 ? 65 TYR A CE2 1 ATOM 251 C CZ . TYR A 1 33 ? 20.702 -41.947 -49.773 1.00 57.30 ? 65 TYR A CZ 1 ATOM 252 O OH . TYR A 1 33 ? 21.979 -41.613 -49.384 1.00 54.48 ? 65 TYR A OH 1 ATOM 253 N N . GLY A 1 34 ? 15.093 -42.176 -48.685 1.00 42.61 ? 66 GLY A N 1 ATOM 254 C CA . GLY A 1 34 ? 14.739 -41.750 -47.344 1.00 37.43 ? 66 GLY A CA 1 ATOM 255 C C . GLY A 1 34 ? 13.239 -41.814 -47.135 1.00 36.15 ? 66 GLY A C 1 ATOM 256 O O . GLY A 1 34 ? 12.487 -42.065 -48.079 1.00 45.00 ? 66 GLY A O 1 ATOM 257 N N . GLU A 1 35 ? 12.805 -41.581 -45.901 1.00 38.36 ? 67 GLU A N 1 ATOM 258 C CA . GLU A 1 35 ? 11.396 -41.713 -45.544 1.00 41.00 ? 67 GLU A CA 1 ATOM 259 C C . GLU A 1 35 ? 10.487 -40.812 -46.382 1.00 47.20 ? 67 GLU A C 1 ATOM 260 O O . GLU A 1 35 ? 9.358 -41.186 -46.695 1.00 41.71 ? 67 GLU A O 1 ATOM 261 C CB . GLU A 1 35 ? 11.189 -41.409 -44.058 1.00 44.06 ? 67 GLU A CB 1 ATOM 262 C CG . GLU A 1 35 ? 9.807 -41.802 -43.540 1.00 61.00 ? 67 GLU A CG 1 ATOM 263 C CD . GLU A 1 35 ? 9.510 -41.231 -42.167 1.00 75.73 ? 67 GLU A CD 1 ATOM 264 O OE1 . GLU A 1 35 ? 10.392 -40.551 -41.601 1.00 71.47 ? 67 GLU A OE1 1 ATOM 265 O OE2 . GLU A 1 35 ? 8.393 -41.458 -41.655 1.00 70.10 ? 67 GLU A OE2 1 ATOM 266 N N . ASN A 1 36 ? 10.982 -39.632 -46.748 1.00 49.87 ? 68 ASN A N 1 ATOM 267 C CA . ASN A 1 36 ? 10.181 -38.665 -47.495 1.00 46.51 ? 68 ASN A CA 1 ATOM 268 C C . ASN A 1 36 ? 10.770 -38.316 -48.860 1.00 46.45 ? 68 ASN A C 1 ATOM 269 O O . ASN A 1 36 ? 10.372 -37.325 -49.474 1.00 47.46 ? 68 ASN A O 1 ATOM 270 C CB . ASN A 1 36 ? 10.007 -37.382 -46.681 1.00 43.49 ? 68 ASN A CB 1 ATOM 271 C CG . ASN A 1 36 ? 9.313 -37.617 -45.355 1.00 50.16 ? 68 ASN A CG 1 ATOM 272 O OD1 . ASN A 1 36 ? 8.413 -38.450 -45.246 1.00 52.95 ? 68 ASN A OD1 1 ATOM 273 N ND2 . ASN A 1 36 ? 9.733 -36.875 -44.336 1.00 56.44 ? 68 ASN A ND2 1 ATOM 274 N N . CYS A 1 37 ? 11.716 -39.130 -49.322 1.00 41.25 ? 69 CYS A N 1 ATOM 275 C CA . CYS A 1 37 ? 12.397 -38.900 -50.597 1.00 46.59 ? 69 CYS A CA 1 ATOM 276 C C . CYS A 1 37 ? 13.072 -37.529 -50.637 1.00 53.06 ? 69 CYS A C 1 ATOM 277 O O . CYS A 1 37 ? 12.892 -36.771 -51.591 1.00 51.70 ? 69 CYS A O 1 ATOM 278 C CB . CYS A 1 37 ? 11.417 -39.029 -51.769 1.00 32.08 ? 69 CYS A CB 1 ATOM 279 S SG . CYS A 1 37 ? 10.404 -40.526 -51.749 1.00 49.45 ? 69 CYS A SG 1 ATOM 280 N N . THR A 1 38 ? 13.848 -37.216 -49.603 1.00 52.31 ? 70 THR A N 1 ATOM 281 C CA . THR A 1 38 ? 14.502 -35.913 -49.507 1.00 47.30 ? 70 THR A CA 1 ATOM 282 C C . THR A 1 38 ? 16.025 -36.023 -49.511 1.00 46.76 ? 70 THR A C 1 ATOM 283 O O . THR A 1 38 ? 16.723 -35.027 -49.701 1.00 54.62 ? 70 THR A O 1 ATOM 284 C CB . THR A 1 38 ? 14.065 -35.157 -48.239 1.00 40.22 ? 70 THR A CB 1 ATOM 285 O OG1 . THR A 1 38 ? 14.433 -35.913 -47.079 1.00 56.28 ? 70 THR A OG1 1 ATOM 286 C CG2 . THR A 1 38 ? 12.560 -34.936 -48.239 1.00 43.91 ? 70 THR A CG2 1 ATOM 287 N N . THR A 1 39 ? 16.536 -37.230 -49.293 1.00 43.21 ? 71 THR A N 1 ATOM 288 C CA . THR A 1 39 ? 17.977 -37.459 -49.312 1.00 53.60 ? 71 THR A CA 1 ATOM 289 C C . THR A 1 39 ? 18.458 -37.762 -50.727 1.00 47.68 ? 71 THR A C 1 ATOM 290 O O . THR A 1 39 ? 18.102 -38.789 -51.304 1.00 49.72 ? 71 THR A O 1 ATOM 291 C CB . THR A 1 39 ? 18.386 -38.616 -48.381 1.00 53.98 ? 71 THR A CB 1 ATOM 292 O OG1 . THR A 1 39 ? 18.008 -38.305 -47.034 1.00 52.45 ? 71 THR A OG1 1 ATOM 293 C CG2 . THR A 1 39 ? 19.889 -38.836 -48.442 1.00 42.50 ? 71 THR A CG2 1 ATOM 294 N N . PRO A 1 40 ? 19.281 -36.864 -51.288 1.00 49.47 ? 72 PRO A N 1 ATOM 295 C CA . PRO A 1 40 ? 19.713 -36.968 -52.684 1.00 48.63 ? 72 PRO A CA 1 ATOM 296 C C . PRO A 1 40 ? 20.694 -38.104 -52.917 1.00 46.41 ? 72 PRO A C 1 ATOM 297 O O . PRO A 1 40 ? 21.566 -38.346 -52.083 1.00 61.73 ? 72 PRO A O 1 ATOM 298 C CB . PRO A 1 40 ? 20.399 -35.618 -52.947 1.00 48.52 ? 72 PRO A CB 1 ATOM 299 C CG . PRO A 1 40 ? 20.051 -34.746 -51.775 1.00 48.12 ? 72 PRO A CG 1 ATOM 300 C CD . PRO A 1 40 ? 19.841 -35.674 -50.631 1.00 48.70 ? 72 PRO A CD 1 ATOM 301 N N . GLU A 1 41 ? 20.548 -38.795 -54.042 1.00 46.17 ? 73 GLU A N 1 ATOM 302 C CA . GLU A 1 41 ? 21.581 -39.709 -54.506 1.00 49.84 ? 73 GLU A CA 1 ATOM 303 C C . GLU A 1 41 ? 22.776 -38.864 -54.930 1.00 50.79 ? 73 GLU A C 1 ATOM 304 O O . GLU A 1 41 ? 22.638 -37.656 -55.127 1.00 54.78 ? 73 GLU A O 1 ATOM 305 C CB . GLU A 1 41 ? 21.075 -40.580 -55.658 1.00 44.81 ? 73 GLU A CB 1 ATOM 306 C CG . GLU A 1 41 ? 19.969 -41.546 -55.253 1.00 52.46 ? 73 GLU A CG 1 ATOM 307 C CD . GLU A 1 41 ? 19.367 -42.285 -56.433 1.00 58.01 ? 73 GLU A CD 1 ATOM 308 O OE1 . GLU A 1 41 ? 19.752 -41.992 -57.585 1.00 61.03 ? 73 GLU A OE1 1 ATOM 309 O OE2 . GLU A 1 41 ? 18.503 -43.159 -56.208 1.00 61.94 ? 73 GLU A OE2 1 ATOM 310 N N . PHE A 1 42 ? 23.944 -39.484 -55.062 1.00 57.45 ? 74 PHE A N 1 ATOM 311 C CA . PHE A 1 42 ? 25.159 -38.734 -55.368 1.00 59.85 ? 74 PHE A CA 1 ATOM 312 C C . PHE A 1 42 ? 25.047 -37.970 -56.684 1.00 56.01 ? 74 PHE A C 1 ATOM 313 O O . PHE A 1 42 ? 25.361 -36.782 -56.750 1.00 54.05 ? 74 PHE A O 1 ATOM 314 C CB . PHE A 1 42 ? 26.374 -39.660 -55.413 1.00 59.58 ? 74 PHE A CB 1 ATOM 315 C CG . PHE A 1 42 ? 27.641 -38.966 -55.827 1.00 75.69 ? 74 PHE A CG 1 ATOM 316 C CD1 . PHE A 1 42 ? 28.247 -38.046 -54.986 1.00 71.91 ? 74 PHE A CD1 1 ATOM 317 C CD2 . PHE A 1 42 ? 28.223 -39.228 -57.057 1.00 67.55 ? 74 PHE A CD2 1 ATOM 318 C CE1 . PHE A 1 42 ? 29.410 -37.400 -55.364 1.00 71.76 ? 74 PHE A CE1 1 ATOM 319 C CE2 . PHE A 1 42 ? 29.387 -38.587 -57.439 1.00 66.33 ? 74 PHE A CE2 1 ATOM 320 C CZ . PHE A 1 42 ? 29.981 -37.672 -56.592 1.00 72.57 ? 74 PHE A CZ 1 ATOM 321 N N . LEU A 1 43 ? 24.591 -38.654 -57.726 1.00 59.96 ? 75 LEU A N 1 ATOM 322 C CA . LEU A 1 43 ? 24.458 -38.037 -59.040 1.00 55.82 ? 75 LEU A CA 1 ATOM 323 C C . LEU A 1 43 ? 23.400 -36.933 -59.027 1.00 57.47 ? 75 LEU A C 1 ATOM 324 O O . LEU A 1 43 ? 23.447 -36.004 -59.833 1.00 57.87 ? 75 LEU A O 1 ATOM 325 C CB . LEU A 1 43 ? 24.106 -39.092 -60.090 1.00 54.23 ? 75 LEU A CB 1 ATOM 326 C CG . LEU A 1 43 ? 24.547 -38.793 -61.523 1.00 64.03 ? 75 LEU A CG 1 ATOM 327 C CD1 . LEU A 1 43 ? 26.036 -39.075 -61.688 1.00 57.07 ? 75 LEU A CD1 1 ATOM 328 C CD2 . LEU A 1 43 ? 23.719 -39.583 -62.529 1.00 62.16 ? 75 LEU A CD2 1 ATOM 329 N N . THR A 1 44 ? 22.453 -37.038 -58.099 1.00 55.73 ? 76 THR A N 1 ATOM 330 C CA . THR A 1 44 ? 21.367 -36.070 -57.990 1.00 48.49 ? 76 THR A CA 1 ATOM 331 C C . THR A 1 44 ? 21.839 -34.738 -57.412 1.00 55.01 ? 76 THR A C 1 ATOM 332 O O . THR A 1 44 ? 21.528 -33.679 -57.956 1.00 59.44 ? 76 THR A O 1 ATOM 333 C CB . THR A 1 44 ? 20.215 -36.615 -57.122 1.00 44.11 ? 76 THR A CB 1 ATOM 334 O OG1 . THR A 1 44 ? 19.617 -37.740 -57.776 1.00 46.26 ? 76 THR A OG1 1 ATOM 335 C CG2 . THR A 1 44 ? 19.155 -35.546 -56.899 1.00 42.20 ? 76 THR A CG2 1 ATOM 336 N N . ARG A 1 45 ? 22.593 -34.786 -56.317 1.00 58.88 ? 77 ARG A N 1 ATOM 337 C CA . ARG A 1 45 ? 23.056 -33.555 -55.680 1.00 70.39 ? 77 ARG A CA 1 ATOM 338 C C . ARG A 1 45 ? 24.116 -32.853 -56.526 1.00 62.31 ? 77 ARG A C 1 ATOM 339 O O . ARG A 1 45 ? 24.429 -31.687 -56.293 1.00 59.92 ? 77 ARG A O 1 ATOM 340 C CB . ARG A 1 45 ? 23.596 -33.827 -54.272 1.00 63.29 ? 77 ARG A CB 1 ATOM 341 C CG . ARG A 1 45 ? 24.732 -34.828 -54.194 1.00 61.22 ? 77 ARG A CG 1 ATOM 342 C CD . ARG A 1 45 ? 25.513 -34.664 -52.893 1.00 77.87 ? 77 ARG A CD 1 ATOM 343 N NE . ARG A 1 45 ? 24.661 -34.758 -51.709 1.00 79.79 ? 77 ARG A NE 1 ATOM 344 C CZ . ARG A 1 45 ? 24.497 -35.864 -50.990 1.00 90.33 ? 77 ARG A CZ 1 ATOM 345 N NH1 . ARG A 1 45 ? 25.128 -36.980 -51.331 1.00 71.77 ? 77 ARG A NH1 1 ATOM 346 N NH2 . ARG A 1 45 ? 23.702 -35.854 -49.927 1.00 63.21 ? 77 ARG A NH2 1 ATOM 347 N N . ILE A 1 46 ? 24.663 -33.562 -57.508 1.00 58.94 ? 78 ILE A N 1 ATOM 348 C CA . ILE A 1 46 ? 25.553 -32.940 -58.482 1.00 59.74 ? 78 ILE A CA 1 ATOM 349 C C . ILE A 1 46 ? 24.736 -32.113 -59.471 1.00 67.29 ? 78 ILE A C 1 ATOM 350 O O . ILE A 1 46 ? 25.046 -30.947 -59.723 1.00 66.76 ? 78 ILE A O 1 ATOM 351 C CB . ILE A 1 46 ? 26.391 -33.983 -59.245 1.00 53.73 ? 78 ILE A CB 1 ATOM 352 C CG1 . ILE A 1 46 ? 27.502 -34.530 -58.350 1.00 55.66 ? 78 ILE A CG1 1 ATOM 353 C CG2 . ILE A 1 46 ? 26.984 -33.376 -60.508 1.00 45.49 ? 78 ILE A CG2 1 ATOM 354 C CD1 . ILE A 1 46 ? 28.404 -35.525 -59.049 1.00 63.07 ? 78 ILE A CD1 1 ATOM 355 N N . LYS A 1 47 ? 23.687 -32.719 -60.021 1.00 66.87 ? 79 LYS A N 1 ATOM 356 C CA . LYS A 1 47 ? 22.797 -32.024 -60.946 1.00 61.16 ? 79 LYS A CA 1 ATOM 357 C C . LYS A 1 47 ? 22.118 -30.836 -60.275 1.00 60.19 ? 79 LYS A C 1 ATOM 358 O O . LYS A 1 47 ? 21.832 -29.830 -60.921 1.00 65.25 ? 79 LYS A O 1 ATOM 359 C CB . LYS A 1 47 ? 21.737 -32.978 -61.504 1.00 61.82 ? 79 LYS A CB 1 ATOM 360 C CG . LYS A 1 47 ? 22.284 -34.045 -62.438 1.00 68.62 ? 79 LYS A CG 1 ATOM 361 C CD . LYS A 1 47 ? 21.228 -34.486 -63.442 1.00 83.28 ? 79 LYS A CD 1 ATOM 362 C CE . LYS A 1 47 ? 20.097 -35.256 -62.780 1.00 80.41 ? 79 LYS A CE 1 ATOM 363 N NZ . LYS A 1 47 ? 20.331 -36.727 -62.825 1.00 69.67 ? 79 LYS A NZ 1 ATOM 364 N N . LEU A 1 48 ? 21.868 -30.957 -58.976 1.00 62.75 ? 80 LEU A N 1 ATOM 365 C CA . LEU A 1 48 ? 21.220 -29.894 -58.218 1.00 64.90 ? 80 LEU A CA 1 ATOM 366 C C . LEU A 1 48 ? 22.107 -28.659 -58.082 1.00 68.82 ? 80 LEU A C 1 ATOM 367 O O . LEU A 1 48 ? 21.607 -27.539 -57.980 1.00 64.82 ? 80 LEU A O 1 ATOM 368 C CB . LEU A 1 48 ? 20.817 -30.402 -56.833 1.00 61.59 ? 80 LEU A CB 1 ATOM 369 C CG . LEU A 1 48 ? 19.317 -30.602 -56.610 1.00 62.78 ? 80 LEU A CG 1 ATOM 370 C CD1 . LEU A 1 48 ? 18.695 -31.363 -57.774 1.00 61.03 ? 80 LEU A CD1 1 ATOM 371 C CD2 . LEU A 1 48 ? 19.061 -31.318 -55.288 1.00 60.15 ? 80 LEU A CD2 1 ATOM 372 N N . LEU A 1 49 ? 23.421 -28.865 -58.080 1.00 74.40 ? 81 LEU A N 1 ATOM 373 C CA . LEU A 1 49 ? 24.365 -27.755 -57.983 1.00 73.75 ? 81 LEU A CA 1 ATOM 374 C C . LEU A 1 49 ? 24.485 -27.002 -59.302 1.00 69.47 ? 81 LEU A C 1 ATOM 375 O O . LEU A 1 49 ? 24.642 -25.783 -59.317 1.00 65.69 ? 81 LEU A O 1 ATOM 376 C CB . LEU A 1 49 ? 25.747 -28.250 -57.550 1.00 72.55 ? 81 LEU A CB 1 ATOM 377 C CG . LEU A 1 49 ? 25.907 -28.732 -56.107 1.00 88.69 ? 81 LEU A CG 1 ATOM 378 C CD1 . LEU A 1 49 ? 27.382 -28.930 -55.775 1.00 67.76 ? 81 LEU A CD1 1 ATOM 379 C CD2 . LEU A 1 49 ? 25.243 -27.771 -55.123 1.00 75.53 ? 81 LEU A CD2 1 ATOM 380 N N . LEU A 1 50 ? 24.409 -27.734 -60.409 1.00 66.47 ? 82 LEU A N 1 ATOM 381 C CA . LEU A 1 50 ? 24.607 -27.141 -61.726 1.00 68.01 ? 82 LEU A CA 1 ATOM 382 C C . LEU A 1 50 ? 23.336 -26.509 -62.288 1.00 65.93 ? 82 LEU A C 1 ATOM 383 O O . LEU A 1 50 ? 23.406 -25.572 -63.081 1.00 72.10 ? 82 LEU A O 1 ATOM 384 C CB . LEU A 1 50 ? 25.134 -28.192 -62.707 1.00 68.29 ? 82 LEU A CB 1 ATOM 385 C CG . LEU A 1 50 ? 26.435 -28.900 -62.321 1.00 79.88 ? 82 LEU A CG 1 ATOM 386 C CD1 . LEU A 1 50 ? 26.918 -29.799 -63.453 1.00 61.92 ? 82 LEU A CD1 1 ATOM 387 C CD2 . LEU A 1 50 ? 27.510 -27.896 -61.922 1.00 71.95 ? 82 LEU A CD2 1 ATOM 388 N N . LYS A 1 51 ? 22.181 -27.022 -61.877 1.00 64.50 ? 83 LYS A N 1 ATOM 389 C CA . LYS A 1 51 ? 20.903 -26.567 -62.417 1.00 57.15 ? 83 LYS A CA 1 ATOM 390 C C . LYS A 1 51 ? 20.588 -25.128 -62.022 1.00 54.29 ? 83 LYS A C 1 ATOM 391 O O . LYS A 1 51 ? 20.460 -24.818 -60.838 1.00 51.93 ? 83 LYS A O 1 ATOM 392 C CB . LYS A 1 51 ? 19.773 -27.488 -61.955 1.00 59.77 ? 83 LYS A CB 1 ATOM 393 C CG . LYS A 1 51 ? 18.444 -27.230 -62.644 1.00 53.54 ? 83 LYS A CG 1 ATOM 394 C CD . LYS A 1 51 ? 17.374 -28.175 -62.129 1.00 62.23 ? 83 LYS A CD 1 ATOM 395 C CE . LYS A 1 51 ? 16.079 -28.009 -62.904 1.00 69.45 ? 83 LYS A CE 1 ATOM 396 N NZ . LYS A 1 51 ? 15.022 -28.933 -62.408 1.00 72.10 ? 83 LYS A NZ 1 ATOM 397 N N . PRO A 1 52 ? 20.457 -24.243 -63.021 1.00 52.41 ? 84 PRO A N 1 ATOM 398 C CA . PRO A 1 52 ? 20.115 -22.839 -62.779 1.00 47.23 ? 84 PRO A CA 1 ATOM 399 C C . PRO A 1 52 ? 18.630 -22.658 -62.476 1.00 50.72 ? 84 PRO A C 1 ATOM 400 O O . PRO A 1 52 ? 17.810 -23.460 -62.925 1.00 56.57 ? 84 PRO A O 1 ATOM 401 C CB . PRO A 1 52 ? 20.494 -22.160 -64.095 1.00 43.38 ? 84 PRO A CB 1 ATOM 402 C CG . PRO A 1 52 ? 20.288 -23.220 -65.120 1.00 38.04 ? 84 PRO A CG 1 ATOM 403 C CD . PRO A 1 52 ? 20.657 -24.522 -64.455 1.00 47.63 ? 84 PRO A CD 1 ATOM 404 N N . THR A 1 53 ? 18.295 -21.617 -61.722 1.00 48.57 ? 85 THR A N 1 ATOM 405 C CA . THR A 1 53 ? 16.906 -21.330 -61.381 1.00 44.54 ? 85 THR A CA 1 ATOM 406 C C . THR A 1 53 ? 16.110 -20.936 -62.624 1.00 51.19 ? 85 THR A C 1 ATOM 407 O O . THR A 1 53 ? 16.688 -20.481 -63.613 1.00 50.38 ? 85 THR A O 1 ATOM 408 C CB . THR A 1 53 ? 16.809 -20.205 -60.329 1.00 39.18 ? 85 THR A CB 1 ATOM 409 O OG1 . THR A 1 53 ? 17.423 -19.014 -60.838 1.00 50.80 ? 85 THR A OG1 1 ATOM 410 C CG2 . THR A 1 53 ? 17.507 -20.619 -59.044 1.00 41.19 ? 85 THR A CG2 1 ATOM 411 N N . PRO A 1 54 ? 14.782 -21.134 -62.588 1.00 52.38 ? 86 PRO A N 1 ATOM 412 C CA . PRO A 1 54 ? 13.924 -20.711 -63.700 1.00 48.53 ? 86 PRO A CA 1 ATOM 413 C C . PRO A 1 54 ? 14.034 -19.218 -64.009 1.00 47.48 ? 86 PRO A C 1 ATOM 414 O O . PRO A 1 54 ? 13.941 -18.843 -65.176 1.00 50.72 ? 86 PRO A O 1 ATOM 415 C CB . PRO A 1 54 ? 12.522 -21.066 -63.206 1.00 35.99 ? 86 PRO A CB 1 ATOM 416 C CG . PRO A 1 54 ? 12.742 -22.232 -62.316 1.00 39.45 ? 86 PRO A CG 1 ATOM 417 C CD . PRO A 1 54 ? 14.042 -21.953 -61.612 1.00 53.44 ? 86 PRO A CD 1 ATOM 418 N N . ASN A 1 55 ? 14.236 -18.386 -62.989 1.00 41.51 ? 87 ASN A N 1 ATOM 419 C CA . ASN A 1 55 ? 14.378 -16.949 -63.205 1.00 39.65 ? 87 ASN A CA 1 ATOM 420 C C . ASN A 1 55 ? 15.711 -16.594 -63.860 1.00 39.01 ? 87 ASN A C 1 ATOM 421 O O . ASN A 1 55 ? 15.790 -15.651 -64.645 1.00 43.28 ? 87 ASN A O 1 ATOM 422 C CB . ASN A 1 55 ? 14.221 -16.186 -61.888 1.00 36.39 ? 87 ASN A CB 1 ATOM 423 C CG . ASN A 1 55 ? 12.782 -16.150 -61.405 1.00 49.86 ? 87 ASN A CG 1 ATOM 424 O OD1 . ASN A 1 55 ? 11.852 -16.396 -62.173 1.00 50.54 ? 87 ASN A OD1 1 ATOM 425 N ND2 . ASN A 1 55 ? 12.592 -15.834 -60.129 1.00 50.79 ? 87 ASN A ND2 1 ATOM 426 N N . THR A 1 56 ? 16.754 -17.353 -63.535 1.00 38.58 ? 88 THR A N 1 ATOM 427 C CA . THR A 1 56 ? 18.057 -17.177 -64.168 1.00 40.43 ? 88 THR A CA 1 ATOM 428 C C . THR A 1 56 ? 17.972 -17.507 -65.656 1.00 44.26 ? 88 THR A C 1 ATOM 429 O O . THR A 1 56 ? 18.464 -16.756 -66.499 1.00 44.98 ? 88 THR A O 1 ATOM 430 C CB . THR A 1 56 ? 19.137 -18.061 -63.508 1.00 42.95 ? 88 THR A CB 1 ATOM 431 O OG1 . THR A 1 56 ? 19.381 -17.607 -62.172 1.00 46.30 ? 88 THR A OG1 1 ATOM 432 C CG2 . THR A 1 56 ? 20.436 -18.005 -64.299 1.00 29.02 ? 88 THR A CG2 1 ATOM 433 N N . VAL A 1 57 ? 17.336 -18.633 -65.968 1.00 47.07 ? 89 VAL A N 1 ATOM 434 C CA . VAL A 1 57 ? 17.155 -19.066 -67.349 1.00 42.88 ? 89 VAL A CA 1 ATOM 435 C C . VAL A 1 57 ? 16.296 -18.068 -68.125 1.00 42.75 ? 89 VAL A C 1 ATOM 436 O O . VAL A 1 57 ? 16.583 -17.752 -69.282 1.00 44.91 ? 89 VAL A O 1 ATOM 437 C CB . VAL A 1 57 ? 16.516 -20.470 -67.411 1.00 43.52 ? 89 VAL A CB 1 ATOM 438 C CG1 . VAL A 1 57 ? 16.024 -20.785 -68.815 1.00 46.79 ? 89 VAL A CG1 1 ATOM 439 C CG2 . VAL A 1 57 ? 17.507 -21.526 -66.937 1.00 43.11 ? 89 VAL A CG2 1 ATOM 440 N N . TRP A 1 58 ? 15.251 -17.563 -67.477 1.00 37.26 ? 90 TRP A N 1 ATOM 441 C CA . TRP A 1 58 ? 14.371 -16.581 -68.099 1.00 38.27 ? 90 TRP A CA 1 ATOM 442 C C . TRP A 1 58 ? 15.119 -15.301 -68.462 1.00 46.17 ? 90 TRP A C 1 ATOM 443 O O . TRP A 1 58 ? 14.881 -14.718 -69.520 1.00 46.10 ? 90 TRP A O 1 ATOM 444 C CB . TRP A 1 58 ? 13.197 -16.250 -67.178 1.00 36.89 ? 90 TRP A CB 1 ATOM 445 C CG . TRP A 1 58 ? 12.309 -15.169 -67.712 1.00 41.03 ? 90 TRP A CG 1 ATOM 446 C CD1 . TRP A 1 58 ? 11.221 -15.326 -68.521 1.00 44.56 ? 90 TRP A CD1 1 ATOM 447 C CD2 . TRP A 1 58 ? 12.434 -13.760 -67.480 1.00 45.45 ? 90 TRP A CD2 1 ATOM 448 N NE1 . TRP A 1 58 ? 10.660 -14.104 -68.805 1.00 39.32 ? 90 TRP A NE1 1 ATOM 449 C CE2 . TRP A 1 58 ? 11.387 -13.125 -68.178 1.00 40.20 ? 90 TRP A CE2 1 ATOM 450 C CE3 . TRP A 1 58 ? 13.331 -12.973 -66.749 1.00 49.14 ? 90 TRP A CE3 1 ATOM 451 C CZ2 . TRP A 1 58 ? 11.212 -11.744 -68.167 1.00 45.32 ? 90 TRP A CZ2 1 ATOM 452 C CZ3 . TRP A 1 58 ? 13.154 -11.601 -66.739 1.00 47.38 ? 90 TRP A CZ3 1 ATOM 453 C CH2 . TRP A 1 58 ? 12.103 -11.001 -67.442 1.00 53.92 ? 90 TRP A CH2 1 ATOM 454 N N . TYR A 1 59 ? 16.018 -14.868 -67.582 1.00 45.80 ? 91 TYR A N 1 ATOM 455 C CA . TYR A 1 59 ? 16.812 -13.665 -67.821 1.00 46.48 ? 91 TYR A CA 1 ATOM 456 C C . TYR A 1 59 ? 17.692 -13.824 -69.059 1.00 48.45 ? 91 TYR A C 1 ATOM 457 O O . TYR A 1 59 ? 17.731 -12.948 -69.925 1.00 46.63 ? 91 TYR A O 1 ATOM 458 C CB . TYR A 1 59 ? 17.679 -13.337 -66.599 1.00 39.12 ? 91 TYR A CB 1 ATOM 459 C CG . TYR A 1 59 ? 18.478 -12.057 -66.737 1.00 41.60 ? 91 TYR A CG 1 ATOM 460 C CD1 . TYR A 1 59 ? 19.739 -12.059 -67.324 1.00 38.53 ? 91 TYR A CD1 1 ATOM 461 C CD2 . TYR A 1 59 ? 17.972 -10.846 -66.280 1.00 45.46 ? 91 TYR A CD2 1 ATOM 462 C CE1 . TYR A 1 59 ? 20.469 -10.892 -67.457 1.00 43.57 ? 91 TYR A CE1 1 ATOM 463 C CE2 . TYR A 1 59 ? 18.697 -9.675 -66.406 1.00 45.50 ? 91 TYR A CE2 1 ATOM 464 C CZ . TYR A 1 59 ? 19.943 -9.704 -66.996 1.00 50.96 ? 91 TYR A CZ 1 ATOM 465 O OH . TYR A 1 59 ? 20.665 -8.540 -67.124 1.00 56.74 ? 91 TYR A OH 1 ATOM 466 N N . ILE A 1 60 ? 18.399 -14.946 -69.133 1.00 41.67 ? 92 ILE A N 1 ATOM 467 C CA . ILE A 1 60 ? 19.300 -15.219 -70.246 1.00 43.06 ? 92 ILE A CA 1 ATOM 468 C C . ILE A 1 60 ? 18.533 -15.317 -71.566 1.00 47.53 ? 92 ILE A C 1 ATOM 469 O O . ILE A 1 60 ? 19.030 -14.913 -72.618 1.00 49.87 ? 92 ILE A O 1 ATOM 470 C CB . ILE A 1 60 ? 20.097 -16.518 -70.003 1.00 43.24 ? 92 ILE A CB 1 ATOM 471 C CG1 . ILE A 1 60 ? 20.863 -16.428 -68.680 1.00 42.74 ? 92 ILE A CG1 1 ATOM 472 C CG2 . ILE A 1 60 ? 21.049 -16.794 -71.154 1.00 34.63 ? 92 ILE A CG2 1 ATOM 473 C CD1 . ILE A 1 60 ? 21.700 -17.650 -68.372 1.00 33.26 ? 92 ILE A CD1 1 ATOM 474 N N . LEU A 1 61 ? 17.312 -15.836 -71.502 1.00 47.72 ? 93 LEU A N 1 ATOM 475 C CA . LEU A 1 61 ? 16.497 -16.012 -72.697 1.00 42.73 ? 93 LEU A CA 1 ATOM 476 C C . LEU A 1 61 ? 15.854 -14.708 -73.172 1.00 47.37 ? 93 LEU A C 1 ATOM 477 O O . LEU A 1 61 ? 15.497 -14.582 -74.345 1.00 43.77 ? 93 LEU A O 1 ATOM 478 C CB . LEU A 1 61 ? 15.415 -17.065 -72.448 1.00 40.94 ? 93 LEU A CB 1 ATOM 479 C CG . LEU A 1 61 ? 15.871 -18.523 -72.511 1.00 42.08 ? 93 LEU A CG 1 ATOM 480 C CD1 . LEU A 1 61 ? 14.767 -19.455 -72.046 1.00 39.44 ? 93 LEU A CD1 1 ATOM 481 C CD2 . LEU A 1 61 ? 16.307 -18.878 -73.923 1.00 42.82 ? 93 LEU A CD2 1 ATOM 482 N N . THR A 1 62 ? 15.706 -13.740 -72.271 1.00 45.71 ? 94 THR A N 1 ATOM 483 C CA . THR A 1 62 ? 15.078 -12.470 -72.628 1.00 44.29 ? 94 THR A CA 1 ATOM 484 C C . THR A 1 62 ? 16.084 -11.324 -72.689 1.00 48.29 ? 94 THR A C 1 ATOM 485 O O . THR A 1 62 ? 15.703 -10.160 -72.823 1.00 50.66 ? 94 THR A O 1 ATOM 486 C CB . THR A 1 62 ? 13.956 -12.093 -71.642 1.00 42.65 ? 94 THR A CB 1 ATOM 487 O OG1 . THR A 1 62 ? 14.493 -11.985 -70.318 1.00 47.79 ? 94 THR A OG1 1 ATOM 488 C CG2 . THR A 1 62 ? 12.854 -13.140 -71.662 1.00 37.68 ? 94 THR A CG2 1 ATOM 489 N N . HIS A 1 63 ? 17.366 -11.658 -72.584 1.00 49.82 ? 95 HIS A N 1 ATOM 490 C CA . HIS A 1 63 ? 18.432 -10.675 -72.748 1.00 46.05 ? 95 HIS A CA 1 ATOM 491 C C . HIS A 1 63 ? 19.496 -11.203 -73.704 1.00 51.60 ? 95 HIS A C 1 ATOM 492 O O . HIS A 1 63 ? 19.324 -12.266 -74.306 1.00 51.21 ? 95 HIS A O 1 ATOM 493 C CB . HIS A 1 63 ? 19.058 -10.318 -71.398 1.00 44.96 ? 95 HIS A CB 1 ATOM 494 C CG . HIS A 1 63 ? 18.150 -9.540 -70.497 1.00 47.36 ? 95 HIS A CG 1 ATOM 495 N ND1 . HIS A 1 63 ? 17.300 -10.143 -69.594 1.00 52.09 ? 95 HIS A ND1 1 ATOM 496 C CD2 . HIS A 1 63 ? 17.954 -8.207 -70.365 1.00 55.53 ? 95 HIS A CD2 1 ATOM 497 C CE1 . HIS A 1 63 ? 16.622 -9.214 -68.944 1.00 50.48 ? 95 HIS A CE1 1 ATOM 498 N NE2 . HIS A 1 63 ? 17.000 -8.031 -69.392 1.00 61.36 ? 95 HIS A NE2 1 ATOM 499 N N . PHE A 1 64 ? 20.590 -10.456 -73.835 1.00 51.78 ? 96 PHE A N 1 ATOM 500 C CA . PHE A 1 64 ? 21.686 -10.816 -74.733 1.00 41.99 ? 96 PHE A CA 1 ATOM 501 C C . PHE A 1 64 ? 21.178 -11.046 -76.153 1.00 43.81 ? 96 PHE A C 1 ATOM 502 O O . PHE A 1 64 ? 21.495 -12.057 -76.778 1.00 48.38 ? 96 PHE A O 1 ATOM 503 C CB . PHE A 1 64 ? 22.415 -12.062 -74.224 1.00 36.23 ? 96 PHE A CB 1 ATOM 504 C CG . PHE A 1 64 ? 22.800 -11.989 -72.774 1.00 48.92 ? 96 PHE A CG 1 ATOM 505 C CD1 . PHE A 1 64 ? 23.802 -11.133 -72.351 1.00 51.13 ? 96 PHE A CD1 1 ATOM 506 C CD2 . PHE A 1 64 ? 22.164 -12.782 -71.833 1.00 51.92 ? 96 PHE A CD2 1 ATOM 507 C CE1 . PHE A 1 64 ? 24.158 -11.064 -71.018 1.00 52.68 ? 96 PHE A CE1 1 ATOM 508 C CE2 . PHE A 1 64 ? 22.517 -12.718 -70.497 1.00 47.91 ? 96 PHE A CE2 1 ATOM 509 C CZ . PHE A 1 64 ? 23.516 -11.857 -70.091 1.00 49.26 ? 96 PHE A CZ 1 ATOM 510 N N . LYS A 1 65 ? 20.389 -10.097 -76.649 1.00 45.74 ? 97 LYS A N 1 ATOM 511 C CA . LYS A 1 65 ? 19.740 -10.212 -77.953 1.00 46.95 ? 97 LYS A CA 1 ATOM 512 C C . LYS A 1 65 ? 20.735 -10.425 -79.094 1.00 51.97 ? 97 LYS A C 1 ATOM 513 O O . LYS A 1 65 ? 20.441 -11.129 -80.059 1.00 58.20 ? 97 LYS A O 1 ATOM 514 C CB . LYS A 1 65 ? 18.895 -8.966 -78.227 1.00 43.86 ? 97 LYS A CB 1 ATOM 515 C CG . LYS A 1 65 ? 18.060 -9.042 -79.493 1.00 51.90 ? 97 LYS A CG 1 ATOM 516 C CD . LYS A 1 65 ? 17.100 -7.866 -79.591 1.00 65.66 ? 97 LYS A CD 1 ATOM 517 C CE . LYS A 1 65 ? 16.212 -7.981 -80.819 1.00 71.53 ? 97 LYS A CE 1 ATOM 518 N NZ . LYS A 1 65 ? 15.183 -6.905 -80.867 1.00 82.24 ? 97 LYS A NZ 1 ATOM 519 N N . GLY A 1 66 ? 21.912 -9.819 -78.977 1.00 48.37 ? 98 GLY A N 1 ATOM 520 C CA . GLY A 1 66 ? 22.938 -9.951 -79.994 1.00 44.88 ? 98 GLY A CA 1 ATOM 521 C C . GLY A 1 66 ? 23.490 -11.359 -80.099 1.00 51.64 ? 98 GLY A C 1 ATOM 522 O O . GLY A 1 66 ? 23.762 -11.848 -81.195 1.00 57.06 ? 98 GLY A O 1 ATOM 523 N N . VAL A 1 67 ? 23.658 -12.012 -78.952 1.00 52.83 ? 99 VAL A N 1 ATOM 524 C CA . VAL A 1 67 ? 24.181 -13.373 -78.912 1.00 49.77 ? 99 VAL A CA 1 ATOM 525 C C . VAL A 1 67 ? 23.193 -14.356 -79.534 1.00 55.17 ? 99 VAL A C 1 ATOM 526 O O . VAL A 1 67 ? 23.585 -15.272 -80.260 1.00 50.53 ? 99 VAL A O 1 ATOM 527 C CB . VAL A 1 67 ? 24.495 -13.814 -77.469 1.00 49.47 ? 99 VAL A CB 1 ATOM 528 C CG1 . VAL A 1 67 ? 25.116 -15.205 -77.455 1.00 37.63 ? 99 VAL A CG1 1 ATOM 529 C CG2 . VAL A 1 67 ? 25.413 -12.805 -76.797 1.00 50.46 ? 99 VAL A CG2 1 ATOM 530 N N . TRP A 1 68 ? 21.910 -14.155 -79.250 1.00 53.25 ? 100 TRP A N 1 ATOM 531 C CA . TRP A 1 68 ? 20.866 -15.031 -79.767 1.00 43.80 ? 100 TRP A CA 1 ATOM 532 C C . TRP A 1 68 ? 20.705 -14.886 -81.277 1.00 50.75 ? 100 TRP A C 1 ATOM 533 O O . TRP A 1 68 ? 20.336 -15.842 -81.960 1.00 50.10 ? 100 TRP A O 1 ATOM 534 C CB . TRP A 1 68 ? 19.536 -14.754 -79.064 1.00 39.09 ? 100 TRP A CB 1 ATOM 535 C CG . TRP A 1 68 ? 19.511 -15.237 -77.648 1.00 38.24 ? 100 TRP A CG 1 ATOM 536 C CD1 . TRP A 1 68 ? 19.461 -14.471 -76.521 1.00 37.18 ? 100 TRP A CD1 1 ATOM 537 C CD2 . TRP A 1 68 ? 19.549 -16.601 -77.207 1.00 37.48 ? 100 TRP A CD2 1 ATOM 538 N NE1 . TRP A 1 68 ? 19.459 -15.273 -75.404 1.00 34.87 ? 100 TRP A NE1 1 ATOM 539 C CE2 . TRP A 1 68 ? 19.512 -16.584 -75.798 1.00 36.01 ? 100 TRP A CE2 1 ATOM 540 C CE3 . TRP A 1 68 ? 19.606 -17.833 -77.866 1.00 37.35 ? 100 TRP A CE3 1 ATOM 541 C CZ2 . TRP A 1 68 ? 19.532 -17.752 -75.037 1.00 36.54 ? 100 TRP A CZ2 1 ATOM 542 C CZ3 . TRP A 1 68 ? 19.625 -18.990 -77.109 1.00 36.76 ? 100 TRP A CZ3 1 ATOM 543 C CH2 . TRP A 1 68 ? 19.588 -18.941 -75.710 1.00 40.79 ? 100 TRP A CH2 1 ATOM 544 N N . ASN A 1 69 ? 20.983 -13.693 -81.795 1.00 50.35 ? 101 ASN A N 1 ATOM 545 C CA . ASN A 1 69 ? 20.969 -13.469 -83.237 1.00 52.84 ? 101 ASN A CA 1 ATOM 546 C C . ASN A 1 69 ? 22.001 -14.346 -83.938 1.00 54.36 ? 101 ASN A C 1 ATOM 547 O O . ASN A 1 69 ? 21.809 -14.759 -85.081 1.00 52.51 ? 101 ASN A O 1 ATOM 548 C CB . ASN A 1 69 ? 21.226 -11.997 -83.557 1.00 63.02 ? 101 ASN A CB 1 ATOM 549 C CG . ASN A 1 69 ? 19.990 -11.290 -84.080 1.00 83.39 ? 101 ASN A CG 1 ATOM 550 O OD1 . ASN A 1 69 ? 19.668 -11.376 -85.265 1.00 89.78 ? 101 ASN A OD1 1 ATOM 551 N ND2 . ASN A 1 69 ? 19.293 -10.582 -83.197 1.00 66.08 ? 101 ASN A ND2 1 ATOM 552 N N . ILE A 1 70 ? 23.096 -14.627 -83.239 1.00 51.93 ? 102 ILE A N 1 ATOM 553 C CA . ILE A 1 70 ? 24.132 -15.512 -83.753 1.00 54.05 ? 102 ILE A CA 1 ATOM 554 C C . ILE A 1 70 ? 23.674 -16.963 -83.672 1.00 51.48 ? 102 ILE A C 1 ATOM 555 O O . ILE A 1 70 ? 23.824 -17.727 -84.626 1.00 61.41 ? 102 ILE A O 1 ATOM 556 C CB . ILE A 1 70 ? 25.454 -15.349 -82.975 1.00 54.31 ? 102 ILE A CB 1 ATOM 557 C CG1 . ILE A 1 70 ? 25.838 -13.871 -82.870 1.00 54.37 ? 102 ILE A CG1 1 ATOM 558 C CG2 . ILE A 1 70 ? 26.563 -16.156 -83.632 1.00 42.40 ? 102 ILE A CG2 1 ATOM 559 C CD1 . ILE A 1 70 ? 26.044 -13.193 -84.206 1.00 61.64 ? 102 ILE A CD1 1 ATOM 560 N N . VAL A 1 71 ? 23.110 -17.330 -82.524 1.00 49.02 ? 103 VAL A N 1 ATOM 561 C CA . VAL A 1 71 ? 22.626 -18.687 -82.286 1.00 48.07 ? 103 VAL A CA 1 ATOM 562 C C . VAL A 1 71 ? 21.503 -19.064 -83.250 1.00 46.87 ? 103 VAL A C 1 ATOM 563 O O . VAL A 1 71 ? 21.474 -20.175 -83.782 1.00 44.61 ? 103 VAL A O 1 ATOM 564 C CB . VAL A 1 71 ? 22.132 -18.852 -80.828 1.00 44.11 ? 103 VAL A CB 1 ATOM 565 C CG1 . VAL A 1 71 ? 21.349 -20.144 -80.660 1.00 43.09 ? 103 VAL A CG1 1 ATOM 566 C CG2 . VAL A 1 71 ? 23.307 -18.809 -79.863 1.00 38.03 ? 103 VAL A CG2 1 ATOM 567 N N . ASN A 1 72 ? 20.591 -18.126 -83.487 1.00 42.79 ? 104 ASN A N 1 ATOM 568 C CA . ASN A 1 72 ? 19.444 -18.370 -84.356 1.00 39.63 ? 104 ASN A CA 1 ATOM 569 C C . ASN A 1 72 ? 19.829 -18.674 -85.803 1.00 47.04 ? 104 ASN A C 1 ATOM 570 O O . ASN A 1 72 ? 19.056 -19.289 -86.539 1.00 45.42 ? 104 ASN A O 1 ATOM 571 C CB . ASN A 1 72 ? 18.491 -17.172 -84.322 1.00 40.32 ? 104 ASN A CB 1 ATOM 572 C CG . ASN A 1 72 ? 17.739 -17.062 -83.008 1.00 40.08 ? 104 ASN A CG 1 ATOM 573 O OD1 . ASN A 1 72 ? 17.622 -18.035 -82.265 1.00 44.79 ? 104 ASN A OD1 1 ATOM 574 N ND2 . ASN A 1 72 ? 17.219 -15.874 -82.720 1.00 33.72 ? 104 ASN A ND2 1 ATOM 575 N N . ASN A 1 73 ? 21.022 -18.248 -86.209 1.00 51.56 ? 105 ASN A N 1 ATOM 576 C CA . ASN A 1 73 ? 21.470 -18.465 -87.581 1.00 48.17 ? 105 ASN A CA 1 ATOM 577 C C . ASN A 1 73 ? 22.436 -19.636 -87.714 1.00 48.37 ? 105 ASN A C 1 ATOM 578 O O . ASN A 1 73 ? 22.995 -19.869 -88.785 1.00 50.05 ? 105 ASN A O 1 ATOM 579 C CB . ASN A 1 73 ? 22.111 -17.194 -88.135 1.00 44.02 ? 105 ASN A CB 1 ATOM 580 C CG . ASN A 1 73 ? 21.083 -16.170 -88.572 1.00 54.25 ? 105 ASN A CG 1 ATOM 581 O OD1 . ASN A 1 73 ? 20.596 -16.207 -89.702 1.00 66.59 ? 105 ASN A OD1 1 ATOM 582 N ND2 . ASN A 1 73 ? 20.744 -15.250 -87.676 1.00 52.15 ? 105 ASN A ND2 1 ATOM 583 N N . ILE A 1 74 A 22.631 -20.366 -86.622 1.00 50.30 ? 105 ILE A N 1 ATOM 584 C CA . ILE A 1 74 A 23.394 -21.609 -86.655 1.00 47.62 ? 105 ILE A CA 1 ATOM 585 C C . ILE A 1 74 A 22.435 -22.779 -86.450 1.00 50.49 ? 105 ILE A C 1 ATOM 586 O O . ILE A 1 74 A 22.119 -23.132 -85.313 1.00 50.19 ? 105 ILE A O 1 ATOM 587 C CB . ILE A 1 74 A 24.500 -21.632 -85.583 1.00 47.77 ? 105 ILE A CB 1 ATOM 588 C CG1 . ILE A 1 74 A 25.369 -20.376 -85.691 1.00 44.50 ? 105 ILE A CG1 1 ATOM 589 C CG2 . ILE A 1 74 A 25.350 -22.887 -85.720 1.00 42.11 ? 105 ILE A CG2 1 ATOM 590 C CD1 . ILE A 1 74 A 26.446 -20.281 -84.633 1.00 38.94 ? 105 ILE A CD1 1 ATOM 591 N N . PRO A 1 75 ? 21.962 -23.373 -87.558 1.00 50.36 ? 106 PRO A N 1 ATOM 592 C CA . PRO A 1 75 ? 20.904 -24.392 -87.577 1.00 44.70 ? 106 PRO A CA 1 ATOM 593 C C . PRO A 1 75 ? 21.137 -25.551 -86.611 1.00 47.46 ? 106 PRO A C 1 ATOM 594 O O . PRO A 1 75 ? 20.208 -25.952 -85.911 1.00 53.93 ? 106 PRO A O 1 ATOM 595 C CB . PRO A 1 75 ? 20.927 -24.885 -89.026 1.00 35.86 ? 106 PRO A CB 1 ATOM 596 C CG . PRO A 1 75 ? 21.424 -23.722 -89.799 1.00 40.19 ? 106 PRO A CG 1 ATOM 597 C CD . PRO A 1 75 ? 22.448 -23.068 -88.915 1.00 48.17 ? 106 PRO A CD 1 ATOM 598 N N . PHE A 1 76 ? 22.358 -26.074 -86.575 1.00 50.30 ? 107 PHE A N 1 ATOM 599 C CA . PHE A 1 76 ? 22.682 -27.194 -85.697 1.00 53.24 ? 107 PHE A CA 1 ATOM 600 C C . PHE A 1 76 ? 22.567 -26.785 -84.230 1.00 48.80 ? 107 PHE A C 1 ATOM 601 O O . PHE A 1 76 ? 22.171 -27.582 -83.381 1.00 52.69 ? 107 PHE A O 1 ATOM 602 C CB . PHE A 1 76 ? 24.088 -27.729 -86.010 1.00 51.97 ? 107 PHE A CB 1 ATOM 603 C CG . PHE A 1 76 ? 25.014 -27.762 -84.823 1.00 59.85 ? 107 PHE A CG 1 ATOM 604 C CD1 . PHE A 1 76 ? 25.067 -28.873 -83.993 1.00 62.63 ? 107 PHE A CD1 1 ATOM 605 C CD2 . PHE A 1 76 ? 25.847 -26.688 -84.548 1.00 64.44 ? 107 PHE A CD2 1 ATOM 606 C CE1 . PHE A 1 76 ? 25.918 -28.903 -82.904 1.00 66.14 ? 107 PHE A CE1 1 ATOM 607 C CE2 . PHE A 1 76 ? 26.700 -26.712 -83.461 1.00 62.01 ? 107 PHE A CE2 1 ATOM 608 C CZ . PHE A 1 76 ? 26.737 -27.822 -82.639 1.00 78.09 ? 107 PHE A CZ 1 ATOM 609 N N . LEU A 1 77 ? 22.905 -25.533 -83.942 1.00 48.23 ? 108 LEU A N 1 ATOM 610 C CA . LEU A 1 77 ? 22.871 -25.024 -82.578 1.00 47.04 ? 108 LEU A CA 1 ATOM 611 C C . LEU A 1 77 ? 21.445 -24.659 -82.171 1.00 48.03 ? 108 LEU A C 1 ATOM 612 O O . LEU A 1 77 ? 21.047 -24.854 -81.023 1.00 42.80 ? 108 LEU A O 1 ATOM 613 C CB . LEU A 1 77 ? 23.794 -23.812 -82.439 1.00 53.48 ? 108 LEU A CB 1 ATOM 614 C CG . LEU A 1 77 ? 24.123 -23.345 -81.021 1.00 50.51 ? 108 LEU A CG 1 ATOM 615 C CD1 . LEU A 1 77 ? 24.766 -24.471 -80.233 1.00 43.67 ? 108 LEU A CD1 1 ATOM 616 C CD2 . LEU A 1 77 ? 25.035 -22.128 -81.059 1.00 46.35 ? 108 LEU A CD2 1 ATOM 617 N N . ARG A 1 78 ? 20.681 -24.130 -83.122 1.00 49.03 ? 109 ARG A N 1 ATOM 618 C CA . ARG A 1 78 ? 19.282 -23.798 -82.883 1.00 39.40 ? 109 ARG A CA 1 ATOM 619 C C . ARG A 1 78 ? 18.466 -25.068 -82.653 1.00 46.88 ? 109 ARG A C 1 ATOM 620 O O . ARG A 1 78 ? 17.545 -25.090 -81.834 1.00 38.73 ? 109 ARG A O 1 ATOM 621 C CB . ARG A 1 78 ? 18.710 -23.005 -84.058 1.00 37.44 ? 109 ARG A CB 1 ATOM 622 C CG . ARG A 1 78 ? 17.253 -22.609 -83.894 1.00 31.49 ? 109 ARG A CG 1 ATOM 623 C CD . ARG A 1 78 ? 16.673 -22.095 -85.201 1.00 34.31 ? 109 ARG A CD 1 ATOM 624 N NE . ARG A 1 78 ? 15.235 -21.851 -85.108 1.00 38.30 ? 109 ARG A NE 1 ATOM 625 C CZ . ARG A 1 78 ? 14.417 -21.795 -86.154 1.00 36.88 ? 109 ARG A CZ 1 ATOM 626 N NH1 . ARG A 1 78 ? 14.891 -21.972 -87.380 1.00 37.22 ? 109 ARG A NH1 1 ATOM 627 N NH2 . ARG A 1 78 ? 13.123 -21.570 -85.975 1.00 41.62 ? 109 ARG A NH2 1 ATOM 628 N N . SER A 1 79 ? 18.818 -26.123 -83.382 1.00 47.19 ? 110 SER A N 1 ATOM 629 C CA . SER A 1 79 ? 18.165 -27.419 -83.236 1.00 35.76 ? 110 SER A CA 1 ATOM 630 C C . SER A 1 79 ? 18.487 -28.044 -81.886 1.00 42.62 ? 110 SER A C 1 ATOM 631 O O . SER A 1 79 ? 17.639 -28.697 -81.276 1.00 45.13 ? 110 SER A O 1 ATOM 632 C CB . SER A 1 79 ? 18.589 -28.363 -84.361 1.00 36.03 ? 110 SER A CB 1 ATOM 633 O OG . SER A 1 79 ? 18.158 -27.882 -85.624 1.00 48.23 ? 110 SER A OG 1 ATOM 634 N N . LEU A 1 80 ? 19.715 -27.838 -81.422 1.00 45.56 ? 111 LEU A N 1 ATOM 635 C CA . LEU A 1 80 ? 20.164 -28.412 -80.159 1.00 41.77 ? 111 LEU A CA 1 ATOM 636 C C . LEU A 1 80 ? 19.437 -27.777 -78.978 1.00 42.69 ? 111 LEU A C 1 ATOM 637 O O . LEU A 1 80 ? 19.025 -28.469 -78.046 1.00 39.08 ? 111 LEU A O 1 ATOM 638 C CB . LEU A 1 80 ? 21.675 -28.239 -80.001 1.00 45.51 ? 111 LEU A CB 1 ATOM 639 C CG . LEU A 1 80 ? 22.400 -29.319 -79.201 1.00 54.60 ? 111 LEU A CG 1 ATOM 640 C CD1 . LEU A 1 80 ? 22.399 -30.634 -79.970 1.00 54.50 ? 111 LEU A CD1 1 ATOM 641 C CD2 . LEU A 1 80 ? 23.819 -28.883 -78.869 1.00 61.74 ? 111 LEU A CD2 1 ATOM 642 N N . ILE A 1 81 ? 19.281 -26.456 -79.025 1.00 41.82 ? 112 ILE A N 1 ATOM 643 C CA . ILE A 1 81 ? 18.597 -25.725 -77.963 1.00 38.02 ? 112 ILE A CA 1 ATOM 644 C C . ILE A 1 81 ? 17.113 -26.074 -77.915 1.00 39.60 ? 112 ILE A C 1 ATOM 645 O O . ILE A 1 81 ? 16.567 -26.344 -76.846 1.00 42.81 ? 112 ILE A O 1 ATOM 646 C CB . ILE A 1 81 ? 18.747 -24.200 -78.134 1.00 39.40 ? 112 ILE A CB 1 ATOM 647 C CG1 . ILE A 1 81 ? 20.222 -23.795 -78.096 1.00 38.43 ? 112 ILE A CG1 1 ATOM 648 C CG2 . ILE A 1 81 ? 17.974 -23.465 -77.050 1.00 29.02 ? 112 ILE A CG2 1 ATOM 649 C CD1 . ILE A 1 81 ? 20.878 -24.006 -76.750 1.00 41.83 ? 112 ILE A CD1 1 ATOM 650 N N . MET A 1 82 ? 16.463 -26.071 -79.076 1.00 37.99 ? 113 MET A N 1 ATOM 651 C CA . MET A 1 82 ? 15.035 -26.361 -79.148 1.00 30.18 ? 113 MET A CA 1 ATOM 652 C C . MET A 1 82 ? 14.749 -27.793 -78.707 1.00 35.61 ? 113 MET A C 1 ATOM 653 O O . MET A 1 82 ? 13.728 -28.062 -78.074 1.00 36.40 ? 113 MET A O 1 ATOM 654 C CB . MET A 1 82 ? 14.503 -26.127 -80.563 1.00 25.23 ? 113 MET A CB 1 ATOM 655 C CG . MET A 1 82 ? 12.990 -26.239 -80.678 1.00 24.58 ? 113 MET A CG 1 ATOM 656 S SD . MET A 1 82 ? 12.133 -25.000 -79.683 1.00 34.83 ? 113 MET A SD 1 ATOM 657 C CE . MET A 1 82 ? 10.456 -25.627 -79.708 1.00 27.09 ? 113 MET A CE 1 ATOM 658 N N . LYS A 1 83 ? 15.657 -28.706 -79.036 1.00 41.07 ? 114 LYS A N 1 ATOM 659 C CA . LYS A 1 83 ? 15.521 -30.094 -78.611 1.00 34.62 ? 114 LYS A CA 1 ATOM 660 C C . LYS A 1 83 ? 15.513 -30.192 -77.091 1.00 36.60 ? 114 LYS A C 1 ATOM 661 O O . LYS A 1 83 ? 14.711 -30.925 -76.512 1.00 39.67 ? 114 LYS A O 1 ATOM 662 C CB . LYS A 1 83 ? 16.649 -30.952 -79.182 1.00 38.02 ? 114 LYS A CB 1 ATOM 663 C CG . LYS A 1 83 ? 16.583 -32.406 -78.753 1.00 33.68 ? 114 LYS A CG 1 ATOM 664 C CD . LYS A 1 83 ? 17.809 -33.181 -79.212 1.00 46.66 ? 114 LYS A CD 1 ATOM 665 C CE . LYS A 1 83 ? 17.915 -33.218 -80.729 1.00 53.41 ? 114 LYS A CE 1 ATOM 666 N NZ . LYS A 1 83 ? 19.127 -33.961 -81.183 1.00 70.22 ? 114 LYS A NZ 1 ATOM 667 N N . TYR A 1 84 ? 16.404 -29.442 -76.448 1.00 37.32 ? 115 TYR A N 1 ATOM 668 C CA . TYR A 1 84 ? 16.482 -29.438 -74.993 1.00 40.15 ? 115 TYR A CA 1 ATOM 669 C C . TYR A 1 84 ? 15.236 -28.815 -74.375 1.00 40.71 ? 115 TYR A C 1 ATOM 670 O O . TYR A 1 84 ? 14.787 -29.239 -73.311 1.00 40.05 ? 115 TYR A O 1 ATOM 671 C CB . TYR A 1 84 ? 17.726 -28.691 -74.510 1.00 33.18 ? 115 TYR A CB 1 ATOM 672 C CG . TYR A 1 84 ? 17.807 -28.600 -73.002 1.00 45.95 ? 115 TYR A CG 1 ATOM 673 C CD1 . TYR A 1 84 ? 18.130 -29.715 -72.239 1.00 46.88 ? 115 TYR A CD1 1 ATOM 674 C CD2 . TYR A 1 84 ? 17.549 -27.405 -72.340 1.00 52.06 ? 115 TYR A CD2 1 ATOM 675 C CE1 . TYR A 1 84 ? 18.198 -29.644 -70.859 1.00 45.90 ? 115 TYR A CE1 1 ATOM 676 C CE2 . TYR A 1 84 ? 17.616 -27.324 -70.958 1.00 53.35 ? 115 TYR A CE2 1 ATOM 677 C CZ . TYR A 1 84 ? 17.941 -28.447 -70.224 1.00 55.62 ? 115 TYR A CZ 1 ATOM 678 O OH . TYR A 1 84 ? 18.010 -28.377 -68.852 1.00 60.89 ? 115 TYR A OH 1 ATOM 679 N N . VAL A 1 85 ? 14.684 -27.806 -75.041 1.00 36.24 ? 116 VAL A N 1 ATOM 680 C CA . VAL A 1 85 ? 13.470 -27.159 -74.560 1.00 39.60 ? 116 VAL A CA 1 ATOM 681 C C . VAL A 1 85 ? 12.311 -28.150 -74.563 1.00 36.02 ? 116 VAL A C 1 ATOM 682 O O . VAL A 1 85 ? 11.572 -28.256 -73.586 1.00 35.07 ? 116 VAL A O 1 ATOM 683 C CB . VAL A 1 85 ? 13.104 -25.922 -75.412 1.00 34.27 ? 116 VAL A CB 1 ATOM 684 C CG1 . VAL A 1 85 ? 11.742 -25.382 -75.013 1.00 27.76 ? 116 VAL A CG1 1 ATOM 685 C CG2 . VAL A 1 85 ? 14.165 -24.847 -75.262 1.00 31.57 ? 116 VAL A CG2 1 ATOM 686 N N . LEU A 1 86 ? 12.171 -28.889 -75.658 1.00 32.87 ? 117 LEU A N 1 ATOM 687 C CA . LEU A 1 86 ? 11.095 -29.864 -75.789 1.00 31.88 ? 117 LEU A CA 1 ATOM 688 C C . LEU A 1 86 ? 11.186 -30.978 -74.746 1.00 36.54 ? 117 LEU A C 1 ATOM 689 O O . LEU A 1 86 ? 10.210 -31.270 -74.054 1.00 30.73 ? 117 LEU A O 1 ATOM 690 C CB . LEU A 1 86 ? 11.097 -30.472 -77.191 1.00 30.89 ? 117 LEU A CB 1 ATOM 691 C CG . LEU A 1 86 ? 10.765 -29.530 -78.348 1.00 31.41 ? 117 LEU A CG 1 ATOM 692 C CD1 . LEU A 1 86 ? 10.707 -30.299 -79.659 1.00 31.67 ? 117 LEU A CD1 1 ATOM 693 C CD2 . LEU A 1 86 ? 9.455 -28.804 -78.085 1.00 30.82 ? 117 LEU A CD2 1 ATOM 694 N N . THR A 1 87 ? 12.360 -31.592 -74.636 1.00 38.41 ? 118 THR A N 1 ATOM 695 C CA . THR A 1 87 ? 12.544 -32.746 -73.762 1.00 35.37 ? 118 THR A CA 1 ATOM 696 C C . THR A 1 87 ? 12.478 -32.384 -72.279 1.00 40.22 ? 118 THR A C 1 ATOM 697 O O . THR A 1 87 ? 11.876 -33.110 -71.488 1.00 49.03 ? 118 THR A O 1 ATOM 698 C CB . THR A 1 87 ? 13.885 -33.447 -74.040 1.00 27.09 ? 118 THR A CB 1 ATOM 699 O OG1 . THR A 1 87 ? 14.955 -32.510 -73.880 1.00 38.03 ? 118 THR A OG1 1 ATOM 700 C CG2 . THR A 1 87 ? 13.916 -34.013 -75.456 1.00 24.43 ? 118 THR A CG2 1 ATOM 701 N N . SER A 1 88 ? 13.097 -31.269 -71.903 1.00 37.01 ? 119 SER A N 1 ATOM 702 C CA . SER A 1 88 ? 13.131 -30.858 -70.501 1.00 36.20 ? 119 SER A CA 1 ATOM 703 C C . SER A 1 88 ? 11.752 -30.445 -69.992 1.00 39.55 ? 119 SER A C 1 ATOM 704 O O . SER A 1 88 ? 11.419 -30.684 -68.832 1.00 47.63 ? 119 SER A O 1 ATOM 705 C CB . SER A 1 88 ? 14.125 -29.712 -70.295 1.00 42.59 ? 119 SER A CB 1 ATOM 706 O OG . SER A 1 88 ? 13.741 -28.559 -71.020 1.00 47.91 ? 119 SER A OG 1 ATOM 707 N N . ARG A 1 89 ? 10.957 -29.822 -70.856 1.00 37.70 ? 120 ARG A N 1 ATOM 708 C CA . ARG A 1 89 ? 9.601 -29.425 -70.490 1.00 38.69 ? 120 ARG A CA 1 ATOM 709 C C . ARG A 1 89 ? 8.677 -30.637 -70.398 1.00 37.91 ? 120 ARG A C 1 ATOM 710 O O . ARG A 1 89 ? 7.832 -30.715 -69.507 1.00 39.17 ? 120 ARG A O 1 ATOM 711 C CB . ARG A 1 89 ? 9.036 -28.419 -71.497 1.00 36.67 ? 120 ARG A CB 1 ATOM 712 C CG . ARG A 1 89 ? 9.665 -27.037 -71.437 1.00 34.64 ? 120 ARG A CG 1 ATOM 713 C CD . ARG A 1 89 ? 9.472 -26.392 -70.079 1.00 41.18 ? 120 ARG A CD 1 ATOM 714 N NE . ARG A 1 89 ? 9.852 -24.982 -70.093 1.00 37.94 ? 120 ARG A NE 1 ATOM 715 C CZ . ARG A 1 89 ? 9.970 -24.230 -69.004 1.00 43.24 ? 120 ARG A CZ 1 ATOM 716 N NH1 . ARG A 1 89 ? 9.745 -24.754 -67.807 1.00 43.87 ? 120 ARG A NH1 1 ATOM 717 N NH2 . ARG A 1 89 ? 10.318 -22.955 -69.111 1.00 36.02 ? 120 ARG A NH2 1 ATOM 718 N N . SER A 1 90 ? 8.848 -31.579 -71.321 1.00 36.47 ? 121 SER A N 1 ATOM 719 C CA . SER A 1 90 ? 7.979 -32.752 -71.400 1.00 33.44 ? 121 SER A CA 1 ATOM 720 C C . SER A 1 90 ? 8.150 -33.694 -70.213 1.00 39.41 ? 121 SER A C 1 ATOM 721 O O . SER A 1 90 ? 7.201 -34.366 -69.805 1.00 47.15 ? 121 SER A O 1 ATOM 722 C CB . SER A 1 90 ? 8.238 -33.517 -72.699 1.00 29.40 ? 121 SER A CB 1 ATOM 723 O OG . SER A 1 90 ? 7.962 -32.706 -73.828 1.00 46.25 ? 121 SER A OG 1 ATOM 724 N N . TYR A 1 91 ? 9.360 -33.737 -69.663 1.00 38.28 ? 122 TYR A N 1 ATOM 725 C CA . TYR A 1 91 ? 9.690 -34.641 -68.565 1.00 34.81 ? 122 TYR A CA 1 ATOM 726 C C . TYR A 1 91 ? 8.852 -34.359 -67.316 1.00 37.28 ? 122 TYR A C 1 ATOM 727 O O . TYR A 1 91 ? 8.707 -35.218 -66.444 1.00 39.92 ? 122 TYR A O 1 ATOM 728 C CB . TYR A 1 91 ? 11.185 -34.540 -68.239 1.00 42.73 ? 122 TYR A CB 1 ATOM 729 C CG . TYR A 1 91 ? 11.662 -35.497 -67.169 1.00 70.70 ? 122 TYR A CG 1 ATOM 730 C CD1 . TYR A 1 91 ? 11.871 -36.841 -67.455 1.00 75.02 ? 122 TYR A CD1 1 ATOM 731 C CD2 . TYR A 1 91 ? 11.913 -35.056 -65.876 1.00 60.95 ? 122 TYR A CD2 1 ATOM 732 C CE1 . TYR A 1 91 ? 12.309 -37.720 -66.481 1.00 70.26 ? 122 TYR A CE1 1 ATOM 733 C CE2 . TYR A 1 91 ? 12.352 -35.928 -64.896 1.00 74.66 ? 122 TYR A CE2 1 ATOM 734 C CZ . TYR A 1 91 ? 12.548 -37.258 -65.204 1.00 78.68 ? 122 TYR A CZ 1 ATOM 735 O OH . TYR A 1 91 ? 12.984 -38.127 -64.230 1.00 86.32 ? 122 TYR A OH 1 ATOM 736 N N . LEU A 1 92 ? 8.295 -33.155 -67.241 1.00 31.95 ? 123 LEU A N 1 ATOM 737 C CA . LEU A 1 92 ? 7.481 -32.751 -66.099 1.00 29.80 ? 123 LEU A CA 1 ATOM 738 C C . LEU A 1 92 ? 6.055 -33.292 -66.193 1.00 33.03 ? 123 LEU A C 1 ATOM 739 O O . LEU A 1 92 ? 5.286 -33.204 -65.235 1.00 28.03 ? 123 LEU A O 1 ATOM 740 C CB . LEU A 1 92 ? 7.453 -31.223 -65.978 1.00 30.19 ? 123 LEU A CB 1 ATOM 741 C CG . LEU A 1 92 ? 8.568 -30.520 -65.197 1.00 25.75 ? 123 LEU A CG 1 ATOM 742 C CD1 . LEU A 1 92 ? 8.509 -30.906 -63.734 1.00 34.34 ? 123 LEU A CD1 1 ATOM 743 C CD2 . LEU A 1 92 ? 9.939 -30.830 -65.771 1.00 31.76 ? 123 LEU A CD2 1 ATOM 744 N N . ILE A 1 93 ? 5.708 -33.852 -67.349 1.00 29.21 ? 124 ILE A N 1 ATOM 745 C CA . ILE A 1 93 ? 4.360 -34.361 -67.586 1.00 30.34 ? 124 ILE A CA 1 ATOM 746 C C . ILE A 1 93 ? 4.305 -35.888 -67.558 1.00 36.21 ? 124 ILE A C 1 ATOM 747 O O . ILE A 1 93 ? 5.110 -36.557 -68.205 1.00 37.91 ? 124 ILE A O 1 ATOM 748 C CB . ILE A 1 93 ? 3.810 -33.873 -68.941 1.00 27.86 ? 124 ILE A CB 1 ATOM 749 C CG1 . ILE A 1 93 ? 3.864 -32.350 -69.018 1.00 29.81 ? 124 ILE A CG1 1 ATOM 750 C CG2 . ILE A 1 93 ? 2.391 -34.370 -69.153 1.00 23.75 ? 124 ILE A CG2 1 ATOM 751 C CD1 . ILE A 1 93 ? 3.119 -31.670 -67.901 1.00 27.24 ? 124 ILE A CD1 1 ATOM 752 N N . ASP A 1 94 ? 3.351 -36.433 -66.806 1.00 35.43 ? 125 ASP A N 1 ATOM 753 C CA . ASP A 1 94 ? 3.159 -37.878 -66.739 1.00 31.97 ? 125 ASP A CA 1 ATOM 754 C C . ASP A 1 94 ? 2.451 -38.388 -67.986 1.00 32.97 ? 125 ASP A C 1 ATOM 755 O O . ASP A 1 94 ? 1.318 -38.001 -68.266 1.00 38.86 ? 125 ASP A O 1 ATOM 756 C CB . ASP A 1 94 ? 2.361 -38.264 -65.492 1.00 35.80 ? 125 ASP A CB 1 ATOM 757 C CG . ASP A 1 94 ? 3.134 -38.037 -64.212 1.00 45.08 ? 125 ASP A CG 1 ATOM 758 O OD1 . ASP A 1 94 ? 4.380 -38.062 -64.266 1.00 51.50 ? 125 ASP A OD1 1 ATOM 759 O OD2 . ASP A 1 94 ? 2.499 -37.838 -63.154 1.00 48.26 ? 125 ASP A OD2 1 ATOM 760 N N . SER A 1 95 ? 3.125 -39.258 -68.731 1.00 31.04 ? 126 SER A N 1 ATOM 761 C CA . SER A 1 95 ? 2.556 -39.837 -69.942 1.00 28.82 ? 126 SER A CA 1 ATOM 762 C C . SER A 1 95 ? 3.028 -41.279 -70.108 1.00 33.61 ? 126 SER A C 1 ATOM 763 O O . SER A 1 95 ? 4.219 -41.516 -70.307 1.00 37.78 ? 126 SER A O 1 ATOM 764 C CB . SER A 1 95 ? 2.935 -39.000 -71.165 1.00 26.28 ? 126 SER A CB 1 ATOM 765 O OG . SER A 1 95 ? 2.131 -39.332 -72.283 1.00 37.93 ? 126 SER A OG 1 ATOM 766 N N . PRO A 1 96 ? 2.102 -42.257 -70.031 1.00 34.61 ? 127 PRO A N 1 ATOM 767 C CA . PRO A 1 96 ? 0.638 -42.204 -69.870 1.00 35.67 ? 127 PRO A CA 1 ATOM 768 C C . PRO A 1 96 ? 0.162 -41.500 -68.595 1.00 31.16 ? 127 PRO A C 1 ATOM 769 O O . PRO A 1 96 ? 0.877 -41.511 -67.593 1.00 31.53 ? 127 PRO A O 1 ATOM 770 C CB . PRO A 1 96 ? 0.241 -43.686 -69.830 1.00 32.65 ? 127 PRO A CB 1 ATOM 771 C CG . PRO A 1 96 ? 1.340 -44.394 -70.524 1.00 30.93 ? 127 PRO A CG 1 ATOM 772 C CD . PRO A 1 96 ? 2.577 -43.645 -70.158 1.00 35.59 ? 127 PRO A CD 1 ATOM 773 N N . PRO A 1 97 ? -1.035 -40.892 -68.641 1.00 22.78 ? 128 PRO A N 1 ATOM 774 C CA . PRO A 1 97 ? -1.574 -40.105 -67.526 1.00 25.46 ? 128 PRO A CA 1 ATOM 775 C C . PRO A 1 97 ? -1.881 -40.957 -66.303 1.00 32.04 ? 128 PRO A C 1 ATOM 776 O O . PRO A 1 97 ? -1.926 -42.184 -66.404 1.00 31.92 ? 128 PRO A O 1 ATOM 777 C CB . PRO A 1 97 ? -2.858 -39.511 -68.108 1.00 22.78 ? 128 PRO A CB 1 ATOM 778 C CG . PRO A 1 97 ? -3.263 -40.477 -69.158 1.00 25.40 ? 128 PRO A CG 1 ATOM 779 C CD . PRO A 1 97 ? -1.981 -40.959 -69.767 1.00 27.07 ? 128 PRO A CD 1 ATOM 780 N N . THR A 1 98 ? -2.100 -40.306 -65.165 1.00 29.43 ? 129 THR A N 1 ATOM 781 C CA . THR A 1 98 ? -2.330 -41.018 -63.917 1.00 26.84 ? 129 THR A CA 1 ATOM 782 C C . THR A 1 98 ? -3.624 -40.579 -63.223 1.00 29.50 ? 129 THR A C 1 ATOM 783 O O . THR A 1 98 ? -4.707 -41.064 -63.549 1.00 32.33 ? 129 THR A O 1 ATOM 784 C CB . THR A 1 98 ? -1.141 -40.829 -62.950 1.00 33.19 ? 129 THR A CB 1 ATOM 785 O OG1 . THR A 1 98 ? -0.900 -39.431 -62.751 1.00 31.94 ? 129 THR A OG1 1 ATOM 786 C CG2 . THR A 1 98 ? 0.118 -41.470 -63.522 1.00 28.60 ? 129 THR A CG2 1 ATOM 787 N N . TYR A 1 99 ? -3.506 -39.656 -62.274 1.00 27.71 ? 130 TYR A N 1 ATOM 788 C CA . TYR A 1 99 ? -4.628 -39.283 -61.416 1.00 27.04 ? 130 TYR A CA 1 ATOM 789 C C . TYR A 1 99 ? -5.691 -38.445 -62.121 1.00 29.66 ? 130 TYR A C 1 ATOM 790 O O . TYR A 1 99 ? -5.431 -37.835 -63.157 1.00 33.62 ? 130 TYR A O 1 ATOM 791 C CB . TYR A 1 99 ? -4.117 -38.512 -60.195 1.00 27.63 ? 130 TYR A CB 1 ATOM 792 C CG . TYR A 1 99 ? -2.856 -39.080 -59.583 1.00 30.70 ? 130 TYR A CG 1 ATOM 793 C CD1 . TYR A 1 99 ? -2.888 -40.248 -58.833 1.00 29.98 ? 130 TYR A CD1 1 ATOM 794 C CD2 . TYR A 1 99 ? -1.635 -38.440 -59.748 1.00 29.70 ? 130 TYR A CD2 1 ATOM 795 C CE1 . TYR A 1 99 ? -1.739 -40.767 -58.270 1.00 31.82 ? 130 TYR A CE1 1 ATOM 796 C CE2 . TYR A 1 99 ? -0.481 -38.951 -59.189 1.00 28.63 ? 130 TYR A CE2 1 ATOM 797 C CZ . TYR A 1 99 ? -0.537 -40.114 -58.450 1.00 38.60 ? 130 TYR A CZ 1 ATOM 798 O OH . TYR A 1 99 ? 0.613 -40.627 -57.892 1.00 44.02 ? 130 TYR A OH 1 ATOM 799 N N . ASN A 1 100 ? -6.896 -38.437 -61.554 1.00 26.59 ? 131 ASN A N 1 ATOM 800 C CA . ASN A 1 100 ? -7.918 -37.457 -61.914 1.00 31.05 ? 131 ASN A CA 1 ATOM 801 C C . ASN A 1 100 ? -8.674 -37.003 -60.664 1.00 35.37 ? 131 ASN A C 1 ATOM 802 O O . ASN A 1 100 ? -8.253 -37.294 -59.545 1.00 34.17 ? 131 ASN A O 1 ATOM 803 C CB . ASN A 1 100 ? -8.883 -38.003 -62.979 1.00 25.89 ? 131 ASN A CB 1 ATOM 804 C CG . ASN A 1 100 ? -9.658 -39.232 -62.524 1.00 35.42 ? 131 ASN A CG 1 ATOM 805 O OD1 . ASN A 1 100 ? -9.940 -39.415 -61.341 1.00 37.96 ? 131 ASN A OD1 1 ATOM 806 N ND2 . ASN A 1 100 ? -10.019 -40.080 -63.482 1.00 32.31 ? 131 ASN A ND2 1 ATOM 807 N N . VAL A 1 101 ? -9.788 -36.304 -60.855 1.00 32.90 ? 132 VAL A N 1 ATOM 808 C CA . VAL A 1 101 ? -10.513 -35.694 -59.742 1.00 33.80 ? 132 VAL A CA 1 ATOM 809 C C . VAL A 1 101 ? -11.059 -36.730 -58.749 1.00 37.98 ? 132 VAL A C 1 ATOM 810 O O . VAL A 1 101 ? -11.250 -36.426 -57.569 1.00 38.05 ? 132 VAL A O 1 ATOM 811 C CB . VAL A 1 101 ? -11.678 -34.805 -60.260 1.00 33.93 ? 132 VAL A CB 1 ATOM 812 C CG1 . VAL A 1 101 ? -12.778 -35.653 -60.881 1.00 32.04 ? 132 VAL A CG1 1 ATOM 813 C CG2 . VAL A 1 101 ? -12.231 -33.927 -59.147 1.00 24.51 ? 132 VAL A CG2 1 ATOM 814 N N . HIS A 1 102 ? -11.278 -37.957 -59.214 1.00 34.27 ? 133 HIS A N 1 ATOM 815 C CA . HIS A 1 102 ? -11.862 -38.998 -58.369 1.00 30.09 ? 133 HIS A CA 1 ATOM 816 C C . HIS A 1 102 ? -10.856 -40.057 -57.922 1.00 35.42 ? 133 HIS A C 1 ATOM 817 O O . HIS A 1 102 ? -11.228 -41.006 -57.231 1.00 34.79 ? 133 HIS A O 1 ATOM 818 C CB . HIS A 1 102 ? -13.019 -39.685 -59.098 1.00 30.21 ? 133 HIS A CB 1 ATOM 819 C CG . HIS A 1 102 ? -14.247 -38.838 -59.224 1.00 38.99 ? 133 HIS A CG 1 ATOM 820 N ND1 . HIS A 1 102 ? -15.211 -39.067 -60.182 1.00 38.92 ? 133 HIS A ND1 1 ATOM 821 C CD2 . HIS A 1 102 ? -14.674 -37.770 -58.509 1.00 35.52 ? 133 HIS A CD2 1 ATOM 822 C CE1 . HIS A 1 102 ? -16.176 -38.174 -60.057 1.00 39.27 ? 133 HIS A CE1 1 ATOM 823 N NE2 . HIS A 1 102 ? -15.875 -37.375 -59.048 1.00 38.32 ? 133 HIS A NE2 1 ATOM 824 N N . TYR A 1 103 ? -9.594 -39.909 -58.315 1.00 31.40 ? 134 TYR A N 1 ATOM 825 C CA . TYR A 1 103 ? -8.594 -40.929 -58.003 1.00 27.67 ? 134 TYR A CA 1 ATOM 826 C C . TYR A 1 103 ? -7.232 -40.356 -57.618 1.00 29.93 ? 134 TYR A C 1 ATOM 827 O O . TYR A 1 103 ? -6.487 -39.869 -58.467 1.00 32.84 ? 134 TYR A O 1 ATOM 828 C CB . TYR A 1 103 ? -8.441 -41.888 -59.189 1.00 26.18 ? 134 TYR A CB 1 ATOM 829 C CG . TYR A 1 103 ? -9.657 -42.762 -59.405 1.00 33.43 ? 134 TYR A CG 1 ATOM 830 C CD1 . TYR A 1 103 ? -9.804 -43.963 -58.721 1.00 33.73 ? 134 TYR A CD1 1 ATOM 831 C CD2 . TYR A 1 103 ? -10.666 -42.380 -60.279 1.00 28.45 ? 134 TYR A CD2 1 ATOM 832 C CE1 . TYR A 1 103 ? -10.918 -44.761 -58.906 1.00 31.53 ? 134 TYR A CE1 1 ATOM 833 C CE2 . TYR A 1 103 ? -11.786 -43.171 -60.470 1.00 31.11 ? 134 TYR A CE2 1 ATOM 834 C CZ . TYR A 1 103 ? -11.906 -44.361 -59.782 1.00 28.94 ? 134 TYR A CZ 1 ATOM 835 O OH . TYR A 1 103 ? -13.017 -45.152 -59.969 1.00 33.60 ? 134 TYR A OH 1 ATOM 836 N N . GLY A 1 104 ? -6.912 -40.431 -56.329 1.00 30.61 ? 135 GLY A N 1 ATOM 837 C CA . GLY A 1 104 ? -5.627 -39.982 -55.823 1.00 29.46 ? 135 GLY A CA 1 ATOM 838 C C . GLY A 1 104 ? -4.596 -41.091 -55.902 1.00 33.76 ? 135 GLY A C 1 ATOM 839 O O . GLY A 1 104 ? -3.443 -40.925 -55.501 1.00 35.51 ? 135 GLY A O 1 ATOM 840 N N . TYR A 1 105 ? -5.032 -42.236 -56.413 1.00 30.18 ? 136 TYR A N 1 ATOM 841 C CA . TYR A 1 105 ? -4.152 -43.362 -56.690 1.00 32.57 ? 136 TYR A CA 1 ATOM 842 C C . TYR A 1 105 ? -4.330 -43.755 -58.149 1.00 36.88 ? 136 TYR A C 1 ATOM 843 O O . TYR A 1 105 ? -5.349 -43.432 -58.762 1.00 40.07 ? 136 TYR A O 1 ATOM 844 C CB . TYR A 1 105 ? -4.462 -44.544 -55.765 1.00 26.44 ? 136 TYR A CB 1 ATOM 845 C CG . TYR A 1 105 ? -5.928 -44.915 -55.737 1.00 31.10 ? 136 TYR A CG 1 ATOM 846 C CD1 . TYR A 1 105 ? -6.790 -44.345 -54.809 1.00 26.19 ? 136 TYR A CD1 1 ATOM 847 C CD2 . TYR A 1 105 ? -6.453 -45.822 -56.648 1.00 32.54 ? 136 TYR A CD2 1 ATOM 848 C CE1 . TYR A 1 105 ? -8.132 -44.671 -54.786 1.00 26.95 ? 136 TYR A CE1 1 ATOM 849 C CE2 . TYR A 1 105 ? -7.796 -46.154 -56.633 1.00 28.06 ? 136 TYR A CE2 1 ATOM 850 C CZ . TYR A 1 105 ? -8.630 -45.575 -55.700 1.00 34.20 ? 136 TYR A CZ 1 ATOM 851 O OH . TYR A 1 105 ? -9.967 -45.901 -55.677 1.00 36.92 ? 136 TYR A OH 1 ATOM 852 N N . LYS A 1 106 ? -3.344 -44.441 -58.713 1.00 31.68 ? 137 LYS A N 1 ATOM 853 C CA . LYS A 1 106 ? -3.455 -44.882 -60.096 1.00 26.61 ? 137 LYS A CA 1 ATOM 854 C C . LYS A 1 106 ? -4.444 -46.035 -60.204 1.00 34.11 ? 137 LYS A C 1 ATOM 855 O O . LYS A 1 106 ? -4.440 -46.953 -59.382 1.00 29.10 ? 137 LYS A O 1 ATOM 856 C CB . LYS A 1 106 ? -2.093 -45.296 -60.647 1.00 27.35 ? 137 LYS A CB 1 ATOM 857 C CG . LYS A 1 106 ? -1.005 -44.269 -60.415 1.00 36.07 ? 137 LYS A CG 1 ATOM 858 C CD . LYS A 1 106 ? 0.224 -44.586 -61.240 1.00 31.83 ? 137 LYS A CD 1 ATOM 859 C CE . LYS A 1 106 ? 1.479 -44.099 -60.546 1.00 36.36 ? 137 LYS A CE 1 ATOM 860 N NZ . LYS A 1 106 ? 1.798 -44.935 -59.355 1.00 37.46 ? 137 LYS A NZ 1 ATOM 861 N N . SER A 1 107 ? -5.297 -45.972 -61.220 1.00 28.43 ? 138 SER A N 1 ATOM 862 C CA . SER A 1 107 ? -6.287 -47.011 -61.455 1.00 31.62 ? 138 SER A CA 1 ATOM 863 C C . SER A 1 107 ? -6.593 -47.094 -62.943 1.00 36.27 ? 138 SER A C 1 ATOM 864 O O . SER A 1 107 ? -6.270 -46.176 -63.697 1.00 38.17 ? 138 SER A O 1 ATOM 865 C CB . SER A 1 107 ? -7.560 -46.733 -60.658 1.00 34.32 ? 138 SER A CB 1 ATOM 866 O OG . SER A 1 107 ? -8.160 -45.524 -61.074 1.00 30.55 ? 138 SER A OG 1 ATOM 867 N N . TRP A 1 108 ? -7.217 -48.187 -63.370 1.00 34.00 ? 139 TRP A N 1 ATOM 868 C CA . TRP A 1 108 ? -7.553 -48.338 -64.779 1.00 26.86 ? 139 TRP A CA 1 ATOM 869 C C . TRP A 1 108 ? -8.714 -47.426 -65.162 1.00 35.61 ? 139 TRP A C 1 ATOM 870 O O . TRP A 1 108 ? -8.852 -47.032 -66.323 1.00 36.70 ? 139 TRP A O 1 ATOM 871 C CB . TRP A 1 108 ? -7.894 -49.788 -65.116 1.00 25.48 ? 139 TRP A CB 1 ATOM 872 C CG . TRP A 1 108 ? -7.875 -50.013 -66.582 1.00 26.59 ? 139 TRP A CG 1 ATOM 873 C CD1 . TRP A 1 108 ? -8.947 -50.034 -67.424 1.00 23.95 ? 139 TRP A CD1 1 ATOM 874 C CD2 . TRP A 1 108 ? -6.718 -50.204 -67.399 1.00 29.61 ? 139 TRP A CD2 1 ATOM 875 N NE1 . TRP A 1 108 ? -8.530 -50.244 -68.718 1.00 29.55 ? 139 TRP A NE1 1 ATOM 876 C CE2 . TRP A 1 108 ? -7.163 -50.352 -68.728 1.00 32.16 ? 139 TRP A CE2 1 ATOM 877 C CE3 . TRP A 1 108 ? -5.346 -50.274 -67.136 1.00 24.66 ? 139 TRP A CE3 1 ATOM 878 C CZ2 . TRP A 1 108 ? -6.287 -50.564 -69.789 1.00 27.81 ? 139 TRP A CZ2 1 ATOM 879 C CZ3 . TRP A 1 108 ? -4.479 -50.489 -68.191 1.00 31.97 ? 139 TRP A CZ3 1 ATOM 880 C CH2 . TRP A 1 108 ? -4.952 -50.630 -69.500 1.00 28.04 ? 139 TRP A CH2 1 ATOM 881 N N . GLU A 1 109 ? -9.547 -47.094 -64.182 1.00 35.48 ? 140 GLU A N 1 ATOM 882 C CA . GLU A 1 109 ? -10.647 -46.170 -64.414 1.00 35.81 ? 140 GLU A CA 1 ATOM 883 C C . GLU A 1 109 ? -10.101 -44.784 -64.728 1.00 33.91 ? 140 GLU A C 1 ATOM 884 O O . GLU A 1 109 ? -10.581 -44.115 -65.639 1.00 38.86 ? 140 GLU A O 1 ATOM 885 C CB . GLU A 1 109 ? -11.580 -46.116 -63.204 1.00 33.44 ? 140 GLU A CB 1 ATOM 886 C CG . GLU A 1 109 ? -12.699 -45.096 -63.329 1.00 28.65 ? 140 GLU A CG 1 ATOM 887 C CD . GLU A 1 109 ? -13.690 -45.440 -64.426 1.00 38.14 ? 140 GLU A CD 1 ATOM 888 O OE1 . GLU A 1 109 ? -14.383 -44.521 -64.912 1.00 35.79 ? 140 GLU A OE1 1 ATOM 889 O OE2 . GLU A 1 109 ? -13.782 -46.628 -64.799 1.00 45.21 ? 140 GLU A OE2 1 ATOM 890 N N . ALA A 1 110 ? -9.085 -44.366 -63.981 1.00 28.50 ? 141 ALA A N 1 ATOM 891 C CA . ALA A 1 110 ? -8.476 -43.059 -64.188 1.00 32.33 ? 141 ALA A CA 1 ATOM 892 C C . ALA A 1 110 ? -7.747 -42.980 -65.528 1.00 38.78 ? 141 ALA A C 1 ATOM 893 O O . ALA A 1 110 ? -7.717 -41.924 -66.162 1.00 38.10 ? 141 ALA A O 1 ATOM 894 C CB . ALA A 1 110 ? -7.525 -42.733 -63.050 1.00 27.51 ? 141 ALA A CB 1 ATOM 895 N N . PHE A 1 111 ? -7.166 -44.097 -65.957 1.00 32.74 ? 142 PHE A N 1 ATOM 896 C CA . PHE A 1 111 ? -6.406 -44.129 -67.203 1.00 31.12 ? 142 PHE A CA 1 ATOM 897 C C . PHE A 1 111 ? -7.288 -44.173 -68.448 1.00 34.70 ? 142 PHE A C 1 ATOM 898 O O . PHE A 1 111 ? -7.061 -43.427 -69.402 1.00 31.72 ? 142 PHE A O 1 ATOM 899 C CB . PHE A 1 111 ? -5.456 -45.330 -67.233 1.00 28.57 ? 142 PHE A CB 1 ATOM 900 C CG . PHE A 1 111 ? -4.943 -45.647 -68.610 1.00 33.71 ? 142 PHE A CG 1 ATOM 901 C CD1 . PHE A 1 111 ? -3.929 -44.892 -69.175 1.00 28.19 ? 142 PHE A CD1 1 ATOM 902 C CD2 . PHE A 1 111 ? -5.491 -46.682 -69.351 1.00 35.75 ? 142 PHE A CD2 1 ATOM 903 C CE1 . PHE A 1 111 ? -3.464 -45.169 -70.446 1.00 27.13 ? 142 PHE A CE1 1 ATOM 904 C CE2 . PHE A 1 111 ? -5.031 -46.961 -70.626 1.00 31.40 ? 142 PHE A CE2 1 ATOM 905 C CZ . PHE A 1 111 ? -4.016 -46.204 -71.173 1.00 21.51 ? 142 PHE A CZ 1 ATOM 906 N N . SER A 1 112 ? -8.278 -45.061 -68.440 1.00 29.60 ? 143 SER A N 1 ATOM 907 C CA . SER A 1 112 ? -9.030 -45.377 -69.652 1.00 29.66 ? 143 SER A CA 1 ATOM 908 C C . SER A 1 112 ? -10.199 -44.430 -69.914 1.00 30.82 ? 143 SER A C 1 ATOM 909 O O . SER A 1 112 ? -10.570 -44.197 -71.063 1.00 30.54 ? 143 SER A O 1 ATOM 910 C CB . SER A 1 112 ? -9.545 -46.814 -69.584 1.00 28.89 ? 143 SER A CB 1 ATOM 911 O OG . SER A 1 112 ? -10.399 -46.992 -68.468 1.00 28.97 ? 143 SER A OG 1 ATOM 912 N N . ASN A 1 113 ? -10.779 -43.890 -68.849 1.00 30.45 ? 144 ASN A N 1 ATOM 913 C CA . ASN A 1 113 ? -11.946 -43.023 -68.968 1.00 28.62 ? 144 ASN A CA 1 ATOM 914 C C . ASN A 1 113 ? -11.555 -41.643 -69.498 1.00 32.22 ? 144 ASN A C 1 ATOM 915 O O . ASN A 1 113 ? -11.080 -40.790 -68.750 1.00 37.45 ? 144 ASN A O 1 ATOM 916 C CB . ASN A 1 113 ? -12.652 -42.915 -67.613 1.00 30.48 ? 144 ASN A CB 1 ATOM 917 C CG . ASN A 1 113 ? -14.065 -42.376 -67.720 1.00 33.14 ? 144 ASN A CG 1 ATOM 918 O OD1 . ASN A 1 113 ? -14.342 -41.469 -68.502 1.00 36.62 ? 144 ASN A OD1 1 ATOM 919 N ND2 . ASN A 1 113 ? -14.969 -42.936 -66.926 1.00 40.12 ? 144 ASN A ND2 1 ATOM 920 N N . LEU A 1 114 ? -11.765 -41.435 -70.795 1.00 33.86 ? 145 LEU A N 1 ATOM 921 C CA . LEU A 1 114 ? -11.318 -40.220 -71.474 1.00 27.17 ? 145 LEU A CA 1 ATOM 922 C C . LEU A 1 114 ? -12.187 -38.999 -71.170 1.00 32.64 ? 145 LEU A C 1 ATOM 923 O O . LEU A 1 114 ? -11.875 -37.888 -71.601 1.00 31.66 ? 145 LEU A O 1 ATOM 924 C CB . LEU A 1 114 ? -11.275 -40.454 -72.985 1.00 22.92 ? 145 LEU A CB 1 ATOM 925 C CG . LEU A 1 114 ? -10.284 -41.515 -73.468 1.00 23.11 ? 145 LEU A CG 1 ATOM 926 C CD1 . LEU A 1 114 ? -10.365 -41.679 -74.972 1.00 21.19 ? 145 LEU A CD1 1 ATOM 927 C CD2 . LEU A 1 114 ? -8.865 -41.165 -73.046 1.00 23.18 ? 145 LEU A CD2 1 ATOM 928 N N . SER A 1 115 ? -13.273 -39.202 -70.431 1.00 33.73 ? 146 SER A N 1 ATOM 929 C CA . SER A 1 115 ? -14.182 -38.108 -70.110 1.00 26.69 ? 146 SER A CA 1 ATOM 930 C C . SER A 1 115 ? -13.614 -37.220 -69.004 1.00 33.49 ? 146 SER A C 1 ATOM 931 O O . SER A 1 115 ? -14.071 -36.095 -68.809 1.00 39.29 ? 146 SER A O 1 ATOM 932 C CB . SER A 1 115 ? -15.552 -38.649 -69.700 1.00 34.00 ? 146 SER A CB 1 ATOM 933 O OG . SER A 1 115 ? -16.143 -39.394 -70.753 1.00 45.71 ? 146 SER A OG 1 ATOM 934 N N . TYR A 1 116 ? -12.620 -37.729 -68.283 1.00 30.03 ? 147 TYR A N 1 ATOM 935 C CA . TYR A 1 116 ? -11.950 -36.955 -67.242 1.00 31.39 ? 147 TYR A CA 1 ATOM 936 C C . TYR A 1 116 ? -10.851 -36.058 -67.802 1.00 32.07 ? 147 TYR A C 1 ATOM 937 O O . TYR A 1 116 ? -10.204 -36.398 -68.793 1.00 27.86 ? 147 TYR A O 1 ATOM 938 C CB . TYR A 1 116 ? -11.317 -37.874 -66.194 1.00 36.17 ? 147 TYR A CB 1 ATOM 939 C CG . TYR A 1 116 ? -12.267 -38.593 -65.267 1.00 37.74 ? 147 TYR A CG 1 ATOM 940 C CD1 . TYR A 1 116 ? -12.829 -39.809 -65.626 1.00 38.90 ? 147 TYR A CD1 1 ATOM 941 C CD2 . TYR A 1 116 ? -12.566 -38.076 -64.013 1.00 35.41 ? 147 TYR A CD2 1 ATOM 942 C CE1 . TYR A 1 116 ? -13.684 -40.480 -64.773 1.00 41.54 ? 147 TYR A CE1 1 ATOM 943 C CE2 . TYR A 1 116 ? -13.418 -38.741 -63.151 1.00 37.86 ? 147 TYR A CE2 1 ATOM 944 C CZ . TYR A 1 116 ? -13.975 -39.941 -63.537 1.00 42.95 ? 147 TYR A CZ 1 ATOM 945 O OH . TYR A 1 116 ? -14.825 -40.606 -62.682 1.00 44.09 ? 147 TYR A OH 1 ATOM 946 N N . TYR A 1 117 ? -10.642 -34.915 -67.160 1.00 31.34 ? 148 TYR A N 1 ATOM 947 C CA . TYR A 1 117 ? -9.363 -34.232 -67.260 1.00 31.16 ? 148 TYR A CA 1 ATOM 948 C C . TYR A 1 117 ? -8.401 -35.018 -66.381 1.00 28.03 ? 148 TYR A C 1 ATOM 949 O O . TYR A 1 117 ? -8.788 -35.471 -65.306 1.00 35.52 ? 148 TYR A O 1 ATOM 950 C CB . TYR A 1 117 ? -9.443 -32.779 -66.784 1.00 31.56 ? 148 TYR A CB 1 ATOM 951 C CG . TYR A 1 117 ? -10.151 -31.811 -67.706 1.00 31.87 ? 148 TYR A CG 1 ATOM 952 C CD1 . TYR A 1 117 ? -9.620 -31.485 -68.947 1.00 30.82 ? 148 TYR A CD1 1 ATOM 953 C CD2 . TYR A 1 117 ? -11.329 -31.186 -67.311 1.00 33.18 ? 148 TYR A CD2 1 ATOM 954 C CE1 . TYR A 1 117 ? -10.257 -30.585 -69.782 1.00 30.38 ? 148 TYR A CE1 1 ATOM 955 C CE2 . TYR A 1 117 ? -11.973 -30.285 -68.137 1.00 36.38 ? 148 TYR A CE2 1 ATOM 956 C CZ . TYR A 1 117 ? -11.432 -29.987 -69.371 1.00 40.89 ? 148 TYR A CZ 1 ATOM 957 O OH . TYR A 1 117 ? -12.073 -29.089 -70.193 1.00 39.13 ? 148 TYR A OH 1 ATOM 958 N N . THR A 1 118 ? -7.160 -35.192 -66.816 1.00 24.84 ? 149 THR A N 1 ATOM 959 C CA . THR A 1 118 ? -6.173 -35.831 -65.954 1.00 26.29 ? 149 THR A CA 1 ATOM 960 C C . THR A 1 118 ? -5.672 -34.807 -64.938 1.00 30.85 ? 149 THR A C 1 ATOM 961 O O . THR A 1 118 ? -6.033 -33.632 -65.010 1.00 34.40 ? 149 THR A O 1 ATOM 962 C CB . THR A 1 118 ? -4.993 -36.419 -66.755 1.00 24.74 ? 149 THR A CB 1 ATOM 963 O OG1 . THR A 1 118 ? -4.126 -37.145 -65.874 1.00 30.60 ? 149 THR A OG1 1 ATOM 964 C CG2 . THR A 1 118 ? -4.208 -35.319 -67.440 1.00 21.21 ? 149 THR A CG2 1 ATOM 965 N N . ARG A 1 119 ? -4.855 -35.249 -63.987 1.00 33.52 ? 150 ARG A N 1 ATOM 966 C CA . ARG A 1 119 ? -4.371 -34.363 -62.931 1.00 28.42 ? 150 ARG A CA 1 ATOM 967 C C . ARG A 1 119 ? -2.860 -34.462 -62.729 1.00 32.66 ? 150 ARG A C 1 ATOM 968 O O . ARG A 1 119 ? -2.310 -35.554 -62.577 1.00 34.49 ? 150 ARG A O 1 ATOM 969 C CB . ARG A 1 119 ? -5.093 -34.665 -61.614 1.00 24.40 ? 150 ARG A CB 1 ATOM 970 C CG . ARG A 1 119 ? -6.539 -34.188 -61.575 1.00 27.41 ? 150 ARG A CG 1 ATOM 971 C CD . ARG A 1 119 ? -6.632 -32.701 -61.275 1.00 33.84 ? 150 ARG A CD 1 ATOM 972 N NE . ARG A 1 119 ? -6.375 -32.406 -59.868 1.00 31.37 ? 150 ARG A NE 1 ATOM 973 C CZ . ARG A 1 119 ? -7.323 -32.287 -58.944 1.00 36.15 ? 150 ARG A CZ 1 ATOM 974 N NH1 . ARG A 1 119 ? -8.597 -32.437 -59.278 1.00 33.47 ? 150 ARG A NH1 1 ATOM 975 N NH2 . ARG A 1 119 ? -7.000 -32.016 -57.687 1.00 38.90 ? 150 ARG A NH2 1 ATOM 976 N N . ALA A 1 120 ? -2.195 -33.310 -62.731 1.00 30.19 ? 151 ALA A N 1 ATOM 977 C CA . ALA A 1 120 ? -0.758 -33.251 -62.494 1.00 31.05 ? 151 ALA A CA 1 ATOM 978 C C . ALA A 1 120 ? -0.447 -33.563 -61.032 1.00 29.63 ? 151 ALA A C 1 ATOM 979 O O . ALA A 1 120 ? 0.626 -34.072 -60.708 1.00 37.16 ? 151 ALA A O 1 ATOM 980 C CB . ALA A 1 120 ? -0.211 -31.885 -62.881 1.00 27.17 ? 151 ALA A CB 1 ATOM 981 N N . LEU A 1 121 ? -1.394 -33.243 -60.155 1.00 31.70 ? 152 LEU A N 1 ATOM 982 C CA . LEU A 1 121 ? -1.311 -33.614 -58.745 1.00 30.94 ? 152 LEU A CA 1 ATOM 983 C C . LEU A 1 121 ? -2.622 -34.243 -58.300 1.00 30.60 ? 152 LEU A C 1 ATOM 984 O O . LEU A 1 121 ? -3.698 -33.777 -58.679 1.00 39.24 ? 152 LEU A O 1 ATOM 985 C CB . LEU A 1 121 ? -0.989 -32.402 -57.867 1.00 29.88 ? 152 LEU A CB 1 ATOM 986 C CG . LEU A 1 121 ? 0.470 -31.950 -57.804 1.00 34.65 ? 152 LEU A CG 1 ATOM 987 C CD1 . LEU A 1 121 ? 0.628 -30.808 -56.814 1.00 27.91 ? 152 LEU A CD1 1 ATOM 988 C CD2 . LEU A 1 121 ? 1.373 -33.113 -57.433 1.00 27.07 ? 152 LEU A CD2 1 ATOM 989 N N . PRO A 1 122 ? -2.538 -35.309 -57.494 1.00 31.40 ? 153 PRO A N 1 ATOM 990 C CA . PRO A 1 122 ? -3.738 -35.997 -57.010 1.00 35.05 ? 153 PRO A CA 1 ATOM 991 C C . PRO A 1 122 ? -4.563 -35.089 -56.107 1.00 36.54 ? 153 PRO A C 1 ATOM 992 O O . PRO A 1 122 ? -3.994 -34.233 -55.429 1.00 39.54 ? 153 PRO A O 1 ATOM 993 C CB . PRO A 1 122 ? -3.171 -37.188 -56.233 1.00 35.28 ? 153 PRO A CB 1 ATOM 994 C CG . PRO A 1 122 ? -1.803 -36.755 -55.828 1.00 28.78 ? 153 PRO A CG 1 ATOM 995 C CD . PRO A 1 122 ? -1.304 -35.907 -56.958 1.00 33.64 ? 153 PRO A CD 1 ATOM 996 N N . PRO A 1 123 ? -5.892 -35.258 -56.111 1.00 30.29 ? 154 PRO A N 1 ATOM 997 C CA . PRO A 1 123 ? -6.759 -34.420 -55.279 1.00 30.59 ? 154 PRO A CA 1 ATOM 998 C C . PRO A 1 123 ? -6.581 -34.712 -53.796 1.00 39.34 ? 154 PRO A C 1 ATOM 999 O O . PRO A 1 123 ? -6.207 -35.828 -53.428 1.00 44.33 ? 154 PRO A O 1 ATOM 1000 C CB . PRO A 1 123 ? -8.167 -34.800 -55.746 1.00 32.02 ? 154 PRO A CB 1 ATOM 1001 C CG . PRO A 1 123 ? -8.024 -36.190 -56.258 1.00 32.75 ? 154 PRO A CG 1 ATOM 1002 C CD . PRO A 1 123 ? -6.657 -36.257 -56.877 1.00 34.37 ? 154 PRO A CD 1 ATOM 1003 N N . VAL A 1 124 ? -6.834 -33.712 -52.959 1.00 37.15 ? 155 VAL A N 1 ATOM 1004 C CA . VAL A 1 124 ? -6.826 -33.908 -51.516 1.00 37.85 ? 155 VAL A CA 1 ATOM 1005 C C . VAL A 1 124 ? -7.950 -34.864 -51.134 1.00 43.45 ? 155 VAL A C 1 ATOM 1006 O O . VAL A 1 124 ? -9.097 -34.674 -51.543 1.00 39.41 ? 155 VAL A O 1 ATOM 1007 C CB . VAL A 1 124 ? -6.988 -32.574 -50.757 1.00 39.59 ? 155 VAL A CB 1 ATOM 1008 C CG1 . VAL A 1 124 ? -7.142 -32.822 -49.271 1.00 45.21 ? 155 VAL A CG1 1 ATOM 1009 C CG2 . VAL A 1 124 ? -5.801 -31.665 -51.023 1.00 40.42 ? 155 VAL A CG2 1 ATOM 1010 N N . ALA A 1 125 ? -7.612 -35.896 -50.365 1.00 42.95 ? 156 ALA A N 1 ATOM 1011 C CA . ALA A 1 125 ? -8.581 -36.909 -49.960 1.00 40.68 ? 156 ALA A CA 1 ATOM 1012 C C . ALA A 1 125 ? -9.760 -36.288 -49.215 1.00 43.45 ? 156 ALA A C 1 ATOM 1013 O O . ALA A 1 125 ? -9.618 -35.253 -48.565 1.00 43.97 ? 156 ALA A O 1 ATOM 1014 C CB . ALA A 1 125 ? -7.909 -37.966 -49.102 1.00 42.26 ? 156 ALA A CB 1 ATOM 1015 N N . ASP A 1 126 ? -10.920 -36.928 -49.316 1.00 41.52 ? 157 ASP A N 1 ATOM 1016 C CA . ASP A 1 126 ? -12.147 -36.403 -48.727 1.00 42.05 ? 157 ASP A CA 1 ATOM 1017 C C . ASP A 1 126 ? -12.090 -36.312 -47.202 1.00 50.87 ? 157 ASP A C 1 ATOM 1018 O O . ASP A 1 126 ? -12.664 -35.399 -46.608 1.00 50.06 ? 157 ASP A O 1 ATOM 1019 C CB . ASP A 1 126 ? -13.344 -37.265 -49.141 1.00 46.94 ? 157 ASP A CB 1 ATOM 1020 C CG . ASP A 1 126 ? -13.633 -37.191 -50.629 1.00 55.19 ? 157 ASP A CG 1 ATOM 1021 O OD1 . ASP A 1 126 ? -13.243 -36.191 -51.267 1.00 58.34 ? 157 ASP A OD1 1 ATOM 1022 O OD2 . ASP A 1 126 ? -14.260 -38.133 -51.159 1.00 59.43 ? 157 ASP A OD2 1 ATOM 1023 N N . ASP A 1 127 ? -11.394 -37.252 -46.571 1.00 52.60 ? 158 ASP A N 1 ATOM 1024 C CA . ASP A 1 127 ? -11.408 -37.353 -45.115 1.00 55.36 ? 158 ASP A CA 1 ATOM 1025 C C . ASP A 1 127 ? -10.273 -36.573 -44.452 1.00 55.97 ? 158 ASP A C 1 ATOM 1026 O O . ASP A 1 127 ? -9.913 -36.844 -43.307 1.00 77.75 ? 158 ASP A O 1 ATOM 1027 C CB . ASP A 1 127 ? -11.350 -38.822 -44.685 1.00 53.02 ? 158 ASP A CB 1 ATOM 1028 C CG . ASP A 1 127 ? -10.019 -39.474 -45.006 1.00 75.24 ? 158 ASP A CG 1 ATOM 1029 O OD1 . ASP A 1 127 ? -9.371 -39.061 -45.990 1.00 74.22 ? 158 ASP A OD1 1 ATOM 1030 O OD2 . ASP A 1 127 ? -9.622 -40.403 -44.272 1.00 77.59 ? 158 ASP A OD2 1 ATOM 1031 N N . CYS A 1 128 ? -9.715 -35.605 -45.169 1.00 44.96 ? 159 CYS A N 1 ATOM 1032 C CA . CYS A 1 128 ? -8.691 -34.733 -44.600 1.00 47.06 ? 159 CYS A CA 1 ATOM 1033 C C . CYS A 1 128 ? -9.339 -33.633 -43.763 1.00 52.61 ? 159 CYS A C 1 ATOM 1034 O O . CYS A 1 128 ? -10.423 -33.156 -44.099 1.00 56.74 ? 159 CYS A O 1 ATOM 1035 C CB . CYS A 1 128 ? -7.826 -34.119 -45.701 1.00 49.94 ? 159 CYS A CB 1 ATOM 1036 S SG . CYS A 1 128 ? -6.870 -35.316 -46.655 1.00 52.94 ? 159 CYS A SG 1 ATOM 1037 N N . PRO A 1 129 ? -8.677 -33.228 -42.666 1.00 51.10 ? 160 PRO A N 1 ATOM 1038 C CA . PRO A 1 129 ? -9.212 -32.207 -41.755 1.00 47.65 ? 160 PRO A CA 1 ATOM 1039 C C . PRO A 1 129 ? -9.429 -30.847 -42.416 1.00 49.22 ? 160 PRO A C 1 ATOM 1040 O O . PRO A 1 129 ? -10.469 -30.224 -42.200 1.00 62.34 ? 160 PRO A O 1 ATOM 1041 C CB . PRO A 1 129 ? -8.137 -32.110 -40.663 1.00 47.76 ? 160 PRO A CB 1 ATOM 1042 C CG . PRO A 1 129 ? -6.906 -32.689 -41.270 1.00 43.50 ? 160 PRO A CG 1 ATOM 1043 C CD . PRO A 1 129 ? -7.388 -33.759 -42.194 1.00 47.64 ? 160 PRO A CD 1 ATOM 1044 N N . THR A 1 130 ? -8.462 -30.398 -43.209 1.00 51.38 ? 161 THR A N 1 ATOM 1045 C CA . THR A 1 130 ? -8.548 -29.095 -43.866 1.00 49.73 ? 161 THR A CA 1 ATOM 1046 C C . THR A 1 130 ? -8.592 -29.251 -45.391 1.00 51.07 ? 161 THR A C 1 ATOM 1047 O O . THR A 1 130 ? -8.185 -30.288 -45.918 1.00 55.10 ? 161 THR A O 1 ATOM 1048 C CB . THR A 1 130 ? -7.359 -28.193 -43.463 1.00 52.79 ? 161 THR A CB 1 ATOM 1049 O OG1 . THR A 1 130 ? -6.144 -28.719 -44.009 1.00 52.40 ? 161 THR A OG1 1 ATOM 1050 C CG2 . THR A 1 130 ? -7.240 -28.108 -41.949 1.00 53.29 ? 161 THR A CG2 1 ATOM 1051 N N . PRO A 1 131 ? -9.102 -28.228 -46.105 1.00 54.10 ? 162 PRO A N 1 ATOM 1052 C CA . PRO A 1 131 ? -9.194 -28.290 -47.570 1.00 42.42 ? 162 PRO A CA 1 ATOM 1053 C C . PRO A 1 131 ? -7.859 -28.534 -48.282 1.00 48.59 ? 162 PRO A C 1 ATOM 1054 O O . PRO A 1 131 ? -7.850 -29.165 -49.339 1.00 53.88 ? 162 PRO A O 1 ATOM 1055 C CB . PRO A 1 131 ? -9.748 -26.913 -47.940 1.00 39.84 ? 162 PRO A CB 1 ATOM 1056 C CG . PRO A 1 131 ? -10.536 -26.503 -46.754 1.00 49.32 ? 162 PRO A CG 1 ATOM 1057 C CD . PRO A 1 131 ? -9.774 -27.028 -45.569 1.00 55.49 ? 162 PRO A CD 1 ATOM 1058 N N . MET A 1 132 ? -6.757 -28.046 -47.719 1.00 42.81 ? 163 MET A N 1 ATOM 1059 C CA . MET A 1 132 ? -5.449 -28.210 -48.349 1.00 42.44 ? 163 MET A CA 1 ATOM 1060 C C . MET A 1 132 ? -4.662 -29.374 -47.756 1.00 50.33 ? 163 MET A C 1 ATOM 1061 O O . MET A 1 132 ? -3.473 -29.534 -48.034 1.00 48.12 ? 163 MET A O 1 ATOM 1062 C CB . MET A 1 132 ? -4.632 -26.923 -48.230 1.00 41.18 ? 163 MET A CB 1 ATOM 1063 C CG . MET A 1 132 ? -5.222 -25.748 -48.987 1.00 49.45 ? 163 MET A CG 1 ATOM 1064 S SD . MET A 1 132 ? -5.322 -26.055 -50.759 1.00 52.39 ? 163 MET A SD 1 ATOM 1065 C CE . MET A 1 132 ? -6.248 -24.627 -51.304 1.00 58.33 ? 163 MET A CE 1 ATOM 1066 N N . GLY A 1 133 ? -5.327 -30.186 -46.941 1.00 48.56 ? 164 GLY A N 1 ATOM 1067 C CA . GLY A 1 133 ? -4.679 -31.316 -46.302 1.00 49.02 ? 164 GLY A CA 1 ATOM 1068 C C . GLY A 1 133 ? -4.761 -31.252 -44.790 1.00 47.64 ? 164 GLY A C 1 ATOM 1069 O O . GLY A 1 133 ? -5.728 -31.728 -44.196 1.00 50.43 ? 164 GLY A O 1 ATOM 1070 N N . VAL A 1 134 ? -3.747 -30.660 -44.164 1.00 46.06 ? 165 VAL A N 1 ATOM 1071 C CA . VAL A 1 134 ? -3.734 -30.502 -42.712 1.00 45.85 ? 165 VAL A CA 1 ATOM 1072 C C . VAL A 1 134 ? -3.522 -29.046 -42.294 1.00 52.79 ? 165 VAL A C 1 ATOM 1073 O O . VAL A 1 134 ? -3.895 -28.652 -41.187 1.00 53.16 ? 165 VAL A O 1 ATOM 1074 C CB . VAL A 1 134 ? -2.642 -31.380 -42.056 1.00 43.91 ? 165 VAL A CB 1 ATOM 1075 C CG1 . VAL A 1 134 ? -2.931 -32.853 -42.296 1.00 43.14 ? 165 VAL A CG1 1 ATOM 1076 C CG2 . VAL A 1 134 ? -1.262 -31.010 -42.579 1.00 40.22 ? 165 VAL A CG2 1 ATOM 1077 N N . LYS A 1 135 ? -2.934 -28.249 -43.182 1.00 52.39 ? 166 LYS A N 1 ATOM 1078 C CA . LYS A 1 135 ? -2.649 -26.848 -42.885 1.00 45.96 ? 166 LYS A CA 1 ATOM 1079 C C . LYS A 1 135 ? -3.867 -25.957 -43.108 1.00 48.47 ? 166 LYS A C 1 ATOM 1080 O O . LYS A 1 135 ? -4.759 -26.292 -43.888 1.00 46.64 ? 166 LYS A O 1 ATOM 1081 C CB . LYS A 1 135 ? -1.485 -26.343 -43.740 1.00 38.67 ? 166 LYS A CB 1 ATOM 1082 C CG . LYS A 1 135 ? -0.148 -27.010 -43.458 1.00 40.47 ? 166 LYS A CG 1 ATOM 1083 C CD . LYS A 1 135 ? 0.947 -26.381 -44.308 1.00 49.44 ? 166 LYS A CD 1 ATOM 1084 C CE . LYS A 1 135 ? 2.278 -27.091 -44.132 1.00 58.46 ? 166 LYS A CE 1 ATOM 1085 N NZ . LYS A 1 135 ? 2.781 -26.998 -42.736 1.00 68.68 ? 166 LYS A NZ 1 ATOM 1086 N N . GLY A 1 136 ? -3.894 -24.819 -42.420 1.00 45.94 ? 167 GLY A N 1 ATOM 1087 C CA . GLY A 1 136 ? -4.955 -23.843 -42.590 1.00 44.20 ? 167 GLY A CA 1 ATOM 1088 C C . GLY A 1 136 ? -6.187 -24.118 -41.750 1.00 49.36 ? 167 GLY A C 1 ATOM 1089 O O . GLY A 1 136 ? -6.220 -25.064 -40.964 1.00 58.14 ? 167 GLY A O 1 ATOM 1090 N N . ASN A 1 137 ? -7.207 -23.282 -41.921 1.00 49.87 ? 168 ASN A N 1 ATOM 1091 C CA . ASN A 1 137 ? -8.455 -23.426 -41.182 1.00 59.57 ? 168 ASN A CA 1 ATOM 1092 C C . ASN A 1 137 ? -9.381 -24.458 -41.818 1.00 56.75 ? 168 ASN A C 1 ATOM 1093 O O . ASN A 1 137 ? -9.076 -25.012 -42.873 1.00 63.53 ? 168 ASN A O 1 ATOM 1094 C CB . ASN A 1 137 ? -9.170 -22.076 -41.076 1.00 59.11 ? 168 ASN A CB 1 ATOM 1095 C CG . ASN A 1 137 ? -8.375 -21.057 -40.283 1.00 63.72 ? 168 ASN A CG 1 ATOM 1096 O OD1 . ASN A 1 137 ? -7.580 -20.299 -40.841 1.00 65.78 ? 168 ASN A OD1 1 ATOM 1097 N ND2 . ASN A 1 137 ? -8.583 -21.035 -38.971 1.00 61.84 ? 168 ASN A ND2 1 ATOM 1098 N N . LYS A 1 138 ? -10.513 -24.710 -41.170 1.00 64.33 ? 169 LYS A N 1 ATOM 1099 C CA . LYS A 1 138 ? -11.460 -25.713 -41.644 1.00 69.86 ? 169 LYS A CA 1 ATOM 1100 C C . LYS A 1 138 ? -12.080 -25.298 -42.976 1.00 67.57 ? 169 LYS A C 1 ATOM 1101 O O . LYS A 1 138 ? -12.416 -26.144 -43.807 1.00 64.43 ? 169 LYS A O 1 ATOM 1102 C CB . LYS A 1 138 ? -12.554 -25.948 -40.602 1.00 82.08 ? 169 LYS A CB 1 ATOM 1103 C CG . LYS A 1 138 ? -13.399 -27.185 -40.860 1.00 93.94 ? 169 LYS A CG 1 ATOM 1104 C CD . LYS A 1 138 ? -14.547 -27.289 -39.868 1.00 110.77 ? 169 LYS A CD 1 ATOM 1105 C CE . LYS A 1 138 ? -14.047 -27.283 -38.432 1.00 116.13 ? 169 LYS A CE 1 ATOM 1106 N NZ . LYS A 1 138 ? -15.170 -27.358 -37.456 1.00 99.32 ? 169 LYS A NZ 1 ATOM 1107 N N . GLU A 1 139 ? -12.230 -23.992 -43.170 1.00 68.38 ? 170 GLU A N 1 ATOM 1108 C CA . GLU A 1 139 ? -12.765 -23.455 -44.416 1.00 61.54 ? 170 GLU A CA 1 ATOM 1109 C C . GLU A 1 139 ? -11.770 -22.502 -45.065 1.00 58.90 ? 170 GLU A C 1 ATOM 1110 O O . GLU A 1 139 ? -11.029 -21.799 -44.376 1.00 64.43 ? 170 GLU A O 1 ATOM 1111 C CB . GLU A 1 139 ? -14.088 -22.727 -44.172 1.00 64.36 ? 170 GLU A CB 1 ATOM 1112 C CG . GLU A 1 139 ? -15.217 -23.605 -43.662 1.00 80.93 ? 170 GLU A CG 1 ATOM 1113 C CD . GLU A 1 139 ? -16.459 -22.802 -43.320 1.00 105.21 ? 170 GLU A CD 1 ATOM 1114 O OE1 . GLU A 1 139 ? -17.503 -23.008 -43.974 1.00 107.62 ? 170 GLU A OE1 1 ATOM 1115 O OE2 . GLU A 1 139 ? -16.391 -21.966 -42.394 1.00 102.59 ? 170 GLU A OE2 1 ATOM 1116 N N . LEU A 1 140 ? -11.754 -22.485 -46.394 1.00 54.53 ? 171 LEU A N 1 ATOM 1117 C CA . LEU A 1 140 ? -10.979 -21.498 -47.135 1.00 47.47 ? 171 LEU A CA 1 ATOM 1118 C C . LEU A 1 140 ? -11.719 -20.164 -47.109 1.00 50.49 ? 171 LEU A C 1 ATOM 1119 O O . LEU A 1 140 ? -12.941 -20.142 -46.958 1.00 48.52 ? 171 LEU A O 1 ATOM 1120 C CB . LEU A 1 140 ? -10.740 -21.968 -48.571 1.00 47.30 ? 171 LEU A CB 1 ATOM 1121 C CG . LEU A 1 140 ? -9.643 -23.019 -48.751 1.00 48.91 ? 171 LEU A CG 1 ATOM 1122 C CD1 . LEU A 1 140 ? -9.643 -23.548 -50.176 1.00 40.62 ? 171 LEU A CD1 1 ATOM 1123 C CD2 . LEU A 1 140 ? -8.277 -22.444 -48.384 1.00 36.95 ? 171 LEU A CD2 1 ATOM 1124 N N . PRO A 1 141 ? -10.983 -19.046 -47.241 1.00 46.98 ? 172 PRO A N 1 ATOM 1125 C CA . PRO A 1 141 ? -11.615 -17.721 -47.207 1.00 44.92 ? 172 PRO A CA 1 ATOM 1126 C C . PRO A 1 141 ? -12.687 -17.555 -48.276 1.00 46.87 ? 172 PRO A C 1 ATOM 1127 O O . PRO A 1 141 ? -12.628 -18.228 -49.306 1.00 53.65 ? 172 PRO A O 1 ATOM 1128 C CB . PRO A 1 141 ? -10.443 -16.761 -47.456 1.00 44.05 ? 172 PRO A CB 1 ATOM 1129 C CG . PRO A 1 141 ? -9.355 -17.607 -48.031 1.00 44.88 ? 172 PRO A CG 1 ATOM 1130 C CD . PRO A 1 141 ? -9.523 -18.947 -47.395 1.00 45.40 ? 172 PRO A CD 1 ATOM 1131 N N . ASP A 1 142 ? -13.654 -16.677 -48.017 1.00 48.81 ? 173 ASP A N 1 ATOM 1132 C CA . ASP A 1 142 ? -14.743 -16.412 -48.951 1.00 45.78 ? 173 ASP A CA 1 ATOM 1133 C C . ASP A 1 142 ? -14.192 -16.081 -50.335 1.00 50.01 ? 173 ASP A C 1 ATOM 1134 O O . ASP A 1 142 ? -13.380 -15.168 -50.490 1.00 55.87 ? 173 ASP A O 1 ATOM 1135 C CB . ASP A 1 142 ? -15.618 -15.266 -48.436 1.00 51.69 ? 173 ASP A CB 1 ATOM 1136 C CG . ASP A 1 142 ? -16.963 -15.188 -49.139 1.00 63.57 ? 173 ASP A CG 1 ATOM 1137 O OD1 . ASP A 1 142 ? -17.121 -15.800 -50.217 1.00 73.06 ? 173 ASP A OD1 1 ATOM 1138 O OD2 . ASP A 1 142 ? -17.869 -14.506 -48.611 1.00 71.06 ? 173 ASP A OD2 1 ATOM 1139 N N . SER A 1 143 ? -14.629 -16.840 -51.334 1.00 47.08 ? 174 SER A N 1 ATOM 1140 C CA . SER A 1 143 ? -14.156 -16.649 -52.699 1.00 47.44 ? 174 SER A CA 1 ATOM 1141 C C . SER A 1 143 ? -14.553 -15.275 -53.226 1.00 47.51 ? 174 SER A C 1 ATOM 1142 O O . SER A 1 143 ? -13.829 -14.675 -54.021 1.00 51.09 ? 174 SER A O 1 ATOM 1143 C CB . SER A 1 143 ? -14.700 -17.747 -53.616 1.00 45.88 ? 174 SER A CB 1 ATOM 1144 O OG . SER A 1 143 ? -16.116 -17.736 -53.642 1.00 53.71 ? 174 SER A OG 1 ATOM 1145 N N . LYS A 1 144 ? -15.698 -14.777 -52.771 1.00 51.67 ? 175 LYS A N 1 ATOM 1146 C CA . LYS A 1 144 ? -16.171 -13.459 -53.176 1.00 52.38 ? 175 LYS A CA 1 ATOM 1147 C C . LYS A 1 144 ? -15.269 -12.361 -52.619 1.00 48.86 ? 175 LYS A C 1 ATOM 1148 O O . LYS A 1 144 ? -15.058 -11.335 -53.263 1.00 51.10 ? 175 LYS A O 1 ATOM 1149 C CB . LYS A 1 144 ? -17.615 -13.240 -52.718 1.00 44.08 ? 175 LYS A CB 1 ATOM 1150 C CG . LYS A 1 144 ? -18.224 -11.930 -53.196 1.00 53.97 ? 175 LYS A CG 1 ATOM 1151 C CD . LYS A 1 144 ? -19.591 -11.696 -52.574 1.00 69.84 ? 175 LYS A CD 1 ATOM 1152 C CE . LYS A 1 144 ? -20.141 -10.330 -52.950 1.00 77.89 ? 175 LYS A CE 1 ATOM 1153 N NZ . LYS A 1 144 ? -21.436 -10.048 -52.273 1.00 91.54 ? 175 LYS A NZ 1 ATOM 1154 N N . GLU A 1 145 ? -14.734 -12.583 -51.422 1.00 45.39 ? 176 GLU A N 1 ATOM 1155 C CA . GLU A 1 145 ? -13.841 -11.613 -50.798 1.00 47.96 ? 176 GLU A CA 1 ATOM 1156 C C . GLU A 1 145 ? -12.476 -11.606 -51.474 1.00 49.10 ? 176 GLU A C 1 ATOM 1157 O O . GLU A 1 145 ? -11.905 -10.543 -51.719 1.00 58.75 ? 176 GLU A O 1 ATOM 1158 C CB . GLU A 1 145 ? -13.679 -11.900 -49.304 1.00 59.45 ? 176 GLU A CB 1 ATOM 1159 C CG . GLU A 1 145 ? -14.931 -11.652 -48.479 1.00 63.85 ? 176 GLU A CG 1 ATOM 1160 C CD . GLU A 1 145 ? -14.654 -11.668 -46.987 1.00 89.73 ? 176 GLU A CD 1 ATOM 1161 O OE1 . GLU A 1 145 ? -13.597 -11.145 -46.573 1.00 80.17 ? 176 GLU A OE1 1 ATOM 1162 O OE2 . GLU A 1 145 ? -15.489 -12.206 -46.230 1.00 97.78 ? 176 GLU A OE2 1 ATOM 1163 N N . VAL A 1 146 ? -11.955 -12.795 -51.762 1.00 47.86 ? 177 VAL A N 1 ATOM 1164 C CA . VAL A 1 146 ? -10.694 -12.931 -52.487 1.00 48.32 ? 177 VAL A CA 1 ATOM 1165 C C . VAL A 1 146 ? -10.792 -12.232 -53.839 1.00 49.24 ? 177 VAL A C 1 ATOM 1166 O O . VAL A 1 146 ? -9.877 -11.522 -54.257 1.00 44.41 ? 177 VAL A O 1 ATOM 1167 C CB . VAL A 1 146 ? -10.318 -14.414 -52.699 1.00 43.31 ? 177 VAL A CB 1 ATOM 1168 C CG1 . VAL A 1 146 ? -9.061 -14.534 -53.547 1.00 40.18 ? 177 VAL A CG1 1 ATOM 1169 C CG2 . VAL A 1 146 ? -10.126 -15.112 -51.364 1.00 51.14 ? 177 VAL A CG2 1 ATOM 1170 N N . LEU A 1 147 ? -11.925 -12.427 -54.503 1.00 47.01 ? 178 LEU A N 1 ATOM 1171 C CA . LEU A 1 147 ? -12.175 -11.849 -55.816 1.00 43.41 ? 178 LEU A CA 1 ATOM 1172 C C . LEU A 1 147 ? -12.181 -10.321 -55.792 1.00 50.40 ? 178 LEU A C 1 ATOM 1173 O O . LEU A 1 147 ? -11.602 -9.676 -56.665 1.00 48.65 ? 178 LEU A O 1 ATOM 1174 C CB . LEU A 1 147 ? -13.508 -12.364 -56.362 1.00 41.53 ? 178 LEU A CB 1 ATOM 1175 C CG . LEU A 1 147 ? -13.937 -11.877 -57.743 1.00 50.18 ? 178 LEU A CG 1 ATOM 1176 C CD1 . LEU A 1 147 ? -12.946 -12.336 -58.799 1.00 51.41 ? 178 LEU A CD1 1 ATOM 1177 C CD2 . LEU A 1 147 ? -15.336 -12.374 -58.061 1.00 52.35 ? 178 LEU A CD2 1 ATOM 1178 N N . GLU A 1 148 ? -12.832 -9.747 -54.787 1.00 53.80 ? 179 GLU A N 1 ATOM 1179 C CA . GLU A 1 148 ? -13.016 -8.301 -54.730 1.00 48.32 ? 179 GLU A CA 1 ATOM 1180 C C . GLU A 1 148 ? -11.795 -7.559 -54.195 1.00 49.02 ? 179 GLU A C 1 ATOM 1181 O O . GLU A 1 148 ? -11.581 -6.394 -54.523 1.00 52.65 ? 179 GLU A O 1 ATOM 1182 C CB . GLU A 1 148 ? -14.238 -7.960 -53.876 1.00 48.47 ? 179 GLU A CB 1 ATOM 1183 C CG . GLU A 1 148 ? -15.562 -8.351 -54.514 1.00 57.61 ? 179 GLU A CG 1 ATOM 1184 C CD . GLU A 1 148 ? -16.759 -7.978 -53.661 1.00 65.39 ? 179 GLU A CD 1 ATOM 1185 O OE1 . GLU A 1 148 ? -16.563 -7.578 -52.494 1.00 57.02 ? 179 GLU A OE1 1 ATOM 1186 O OE2 . GLU A 1 148 ? -17.899 -8.086 -54.161 1.00 62.56 ? 179 GLU A OE2 1 ATOM 1187 N N . LYS A 1 149 ? -10.993 -8.231 -53.377 1.00 51.40 ? 180 LYS A N 1 ATOM 1188 C CA . LYS A 1 149 ? -9.886 -7.563 -52.701 1.00 45.50 ? 180 LYS A CA 1 ATOM 1189 C C . LYS A 1 149 ? -8.577 -7.569 -53.493 1.00 50.62 ? 180 LYS A C 1 ATOM 1190 O O . LYS A 1 149 ? -7.785 -6.634 -53.381 1.00 58.17 ? 180 LYS A O 1 ATOM 1191 C CB . LYS A 1 149 ? -9.659 -8.186 -51.321 1.00 43.23 ? 180 LYS A CB 1 ATOM 1192 C CG . LYS A 1 149 ? -10.752 -7.848 -50.319 1.00 50.57 ? 180 LYS A CG 1 ATOM 1193 C CD . LYS A 1 149 ? -10.355 -8.209 -48.899 1.00 61.31 ? 180 LYS A CD 1 ATOM 1194 C CE . LYS A 1 149 ? -11.407 -7.743 -47.905 1.00 64.58 ? 180 LYS A CE 1 ATOM 1195 N NZ . LYS A 1 149 ? -11.643 -6.274 -48.000 1.00 67.35 ? 180 LYS A NZ 1 ATOM 1196 N N . VAL A 1 150 ? -8.340 -8.608 -54.291 1.00 45.81 ? 181 VAL A N 1 ATOM 1197 C CA . VAL A 1 150 ? -7.079 -8.696 -55.028 1.00 46.24 ? 181 VAL A CA 1 ATOM 1198 C C . VAL A 1 150 ? -7.226 -9.038 -56.511 1.00 44.08 ? 181 VAL A C 1 ATOM 1199 O O . VAL A 1 150 ? -6.238 -9.026 -57.245 1.00 47.77 ? 181 VAL A O 1 ATOM 1200 C CB . VAL A 1 150 ? -6.130 -9.746 -54.401 1.00 48.66 ? 181 VAL A CB 1 ATOM 1201 C CG1 . VAL A 1 150 ? -5.772 -9.368 -52.968 1.00 48.80 ? 181 VAL A CG1 1 ATOM 1202 C CG2 . VAL A 1 150 ? -6.743 -11.138 -54.468 1.00 39.94 ? 181 VAL A CG2 1 ATOM 1203 N N . LEU A 1 151 ? -8.440 -9.336 -56.962 1.00 41.64 ? 182 LEU A N 1 ATOM 1204 C CA . LEU A 1 151 ? -8.618 -9.783 -58.343 1.00 41.77 ? 182 LEU A CA 1 ATOM 1205 C C . LEU A 1 151 ? -9.367 -8.791 -59.237 1.00 46.02 ? 182 LEU A C 1 ATOM 1206 O O . LEU A 1 151 ? -9.027 -8.640 -60.410 1.00 48.16 ? 182 LEU A O 1 ATOM 1207 C CB . LEU A 1 151 ? -9.341 -11.133 -58.373 1.00 39.64 ? 182 LEU A CB 1 ATOM 1208 C CG . LEU A 1 151 ? -8.600 -12.347 -57.810 1.00 42.04 ? 182 LEU A CG 1 ATOM 1209 C CD1 . LEU A 1 151 ? -9.406 -13.615 -58.049 1.00 40.85 ? 182 LEU A CD1 1 ATOM 1210 C CD2 . LEU A 1 151 ? -7.210 -12.469 -58.414 1.00 34.35 ? 182 LEU A CD2 1 ATOM 1211 N N . LEU A 1 152 ? -10.386 -8.127 -58.697 1.00 43.73 ? 183 LEU A N 1 ATOM 1212 C CA . LEU A 1 152 ? -11.224 -7.250 -59.513 1.00 39.81 ? 183 LEU A CA 1 ATOM 1213 C C . LEU A 1 152 ? -10.466 -6.026 -60.013 1.00 45.42 ? 183 LEU A C 1 ATOM 1214 O O . LEU A 1 152 ? -9.579 -5.508 -59.338 1.00 44.42 ? 183 LEU A O 1 ATOM 1215 C CB . LEU A 1 152 ? -12.469 -6.812 -58.738 1.00 40.58 ? 183 LEU A CB 1 ATOM 1216 C CG . LEU A 1 152 ? -13.604 -7.837 -58.704 1.00 44.90 ? 183 LEU A CG 1 ATOM 1217 C CD1 . LEU A 1 152 ? -14.900 -7.191 -58.247 1.00 46.98 ? 183 LEU A CD1 1 ATOM 1218 C CD2 . LEU A 1 152 ? -13.778 -8.484 -60.068 1.00 42.88 ? 183 LEU A CD2 1 ATOM 1219 N N . ARG A 1 153 ? -10.835 -5.575 -61.207 1.00 46.70 ? 184 ARG A N 1 ATOM 1220 C CA . ARG A 1 153 ? -10.154 -4.476 -61.879 1.00 46.17 ? 184 ARG A CA 1 ATOM 1221 C C . ARG A 1 153 ? -10.719 -3.116 -61.482 1.00 40.64 ? 184 ARG A C 1 ATOM 1222 O O . ARG A 1 153 ? -11.904 -2.847 -61.675 1.00 38.98 ? 184 ARG A O 1 ATOM 1223 C CB . ARG A 1 153 ? -10.248 -4.660 -63.397 1.00 40.65 ? 184 ARG A CB 1 ATOM 1224 C CG . ARG A 1 153 ? -9.807 -3.458 -64.214 1.00 37.78 ? 184 ARG A CG 1 ATOM 1225 C CD . ARG A 1 153 ? -10.053 -3.695 -65.694 1.00 31.75 ? 184 ARG A CD 1 ATOM 1226 N NE . ARG A 1 153 ? -9.216 -4.770 -66.215 1.00 36.44 ? 184 ARG A NE 1 ATOM 1227 C CZ . ARG A 1 153 ? -9.443 -5.404 -67.360 1.00 35.81 ? 184 ARG A CZ 1 ATOM 1228 N NH1 . ARG A 1 153 ? -10.490 -5.076 -68.105 1.00 38.05 ? 184 ARG A NH1 1 ATOM 1229 N NH2 . ARG A 1 153 ? -8.629 -6.372 -67.756 1.00 33.82 ? 184 ARG A NH2 1 ATOM 1230 N N . ARG A 1 154 ? -9.865 -2.265 -60.921 1.00 40.58 ? 185 ARG A N 1 ATOM 1231 C CA . ARG A 1 154 ? -10.238 -0.884 -60.631 1.00 44.48 ? 185 ARG A CA 1 ATOM 1232 C C . ARG A 1 154 ? -10.001 -0.011 -61.858 1.00 42.81 ? 185 ARG A C 1 ATOM 1233 O O . ARG A 1 154 ? -10.792 0.876 -62.172 1.00 54.32 ? 185 ARG A O 1 ATOM 1234 C CB . ARG A 1 154 ? -9.450 -0.342 -59.438 1.00 36.10 ? 185 ARG A CB 1 ATOM 1235 C CG . ARG A 1 154 ? -9.831 -0.955 -58.097 1.00 41.99 ? 185 ARG A CG 1 ATOM 1236 C CD . ARG A 1 154 ? -8.860 -2.048 -57.688 1.00 49.28 ? 185 ARG A CD 1 ATOM 1237 N NE . ARG A 1 154 ? -8.949 -2.355 -56.262 1.00 59.38 ? 185 ARG A NE 1 ATOM 1238 C CZ . ARG A 1 154 ? -9.640 -3.369 -55.750 1.00 71.40 ? 185 ARG A CZ 1 ATOM 1239 N NH1 . ARG A 1 154 ? -10.313 -4.190 -56.545 1.00 59.19 ? 185 ARG A NH1 1 ATOM 1240 N NH2 . ARG A 1 154 ? -9.656 -3.564 -54.438 1.00 72.03 ? 185 ARG A NH2 1 ATOM 1241 N N . GLU A 1 155 ? -8.895 -0.275 -62.543 1.00 43.16 ? 186 GLU A N 1 ATOM 1242 C CA . GLU A 1 155 ? -8.567 0.395 -63.795 1.00 38.36 ? 186 GLU A CA 1 ATOM 1243 C C . GLU A 1 155 ? -7.771 -0.561 -64.677 1.00 44.68 ? 186 GLU A C 1 ATOM 1244 O O . GLU A 1 155 ? -6.935 -1.319 -64.182 1.00 46.41 ? 186 GLU A O 1 ATOM 1245 C CB . GLU A 1 155 ? -7.774 1.677 -63.541 1.00 36.57 ? 186 GLU A CB 1 ATOM 1246 C CG . GLU A 1 155 ? -7.536 2.517 -64.788 1.00 36.27 ? 186 GLU A CG 1 ATOM 1247 C CD . GLU A 1 155 ? -6.528 3.629 -64.566 1.00 47.99 ? 186 GLU A CD 1 ATOM 1248 O OE1 . GLU A 1 155 ? -5.420 3.340 -64.062 1.00 37.86 ? 186 GLU A OE1 1 ATOM 1249 O OE2 . GLU A 1 155 ? -6.841 4.791 -64.901 1.00 43.67 ? 186 GLU A OE2 1 ATOM 1250 N N . PHE A 1 156 ? -8.039 -0.525 -65.979 1.00 40.99 ? 187 PHE A N 1 ATOM 1251 C CA . PHE A 1 156 ? -7.403 -1.440 -66.924 1.00 37.43 ? 187 PHE A CA 1 ATOM 1252 C C . PHE A 1 156 ? -5.880 -1.384 -66.861 1.00 37.36 ? 187 PHE A C 1 ATOM 1253 O O . PHE A 1 156 ? -5.281 -0.314 -66.973 1.00 48.12 ? 187 PHE A O 1 ATOM 1254 C CB . PHE A 1 156 ? -7.870 -1.139 -68.349 1.00 35.67 ? 187 PHE A CB 1 ATOM 1255 C CG . PHE A 1 156 ? -7.251 -2.026 -69.391 1.00 32.48 ? 187 PHE A CG 1 ATOM 1256 C CD1 . PHE A 1 156 ? -7.620 -3.358 -69.494 1.00 33.85 ? 187 PHE A CD1 1 ATOM 1257 C CD2 . PHE A 1 156 ? -6.307 -1.528 -70.273 1.00 24.77 ? 187 PHE A CD2 1 ATOM 1258 C CE1 . PHE A 1 156 ? -7.054 -4.177 -70.453 1.00 39.98 ? 187 PHE A CE1 1 ATOM 1259 C CE2 . PHE A 1 156 ? -5.738 -2.342 -71.235 1.00 33.95 ? 187 PHE A CE2 1 ATOM 1260 C CZ . PHE A 1 156 ? -6.113 -3.668 -71.326 1.00 41.15 ? 187 PHE A CZ 1 ATOM 1261 N N . ILE A 1 157 ? -5.265 -2.546 -66.671 1.00 37.96 ? 188 ILE A N 1 ATOM 1262 C CA . ILE A 1 157 ? -3.814 -2.665 -66.688 1.00 37.09 ? 188 ILE A CA 1 ATOM 1263 C C . ILE A 1 157 ? -3.371 -3.377 -67.958 1.00 36.37 ? 188 ILE A C 1 ATOM 1264 O O . ILE A 1 157 ? -3.585 -4.580 -68.106 1.00 43.22 ? 188 ILE A O 1 ATOM 1265 C CB . ILE A 1 157 ? -3.285 -3.435 -65.465 1.00 34.62 ? 188 ILE A CB 1 ATOM 1266 C CG1 . ILE A 1 157 ? -3.786 -2.796 -64.169 1.00 31.08 ? 188 ILE A CG1 1 ATOM 1267 C CG2 . ILE A 1 157 ? -1.764 -3.493 -65.486 1.00 30.81 ? 188 ILE A CG2 1 ATOM 1268 C CD1 . ILE A 1 157 ? -3.332 -3.516 -62.922 1.00 29.24 ? 188 ILE A CD1 1 ATOM 1269 N N . PRO A 1 158 ? -2.747 -2.634 -68.881 1.00 40.73 ? 189 PRO A N 1 ATOM 1270 C CA . PRO A 1 158 ? -2.320 -3.191 -70.168 1.00 40.23 ? 189 PRO A CA 1 ATOM 1271 C C . PRO A 1 158 ? -1.122 -4.129 -70.036 1.00 33.85 ? 189 PRO A C 1 ATOM 1272 O O . PRO A 1 158 ? -0.333 -4.005 -69.100 1.00 37.59 ? 189 PRO A O 1 ATOM 1273 C CB . PRO A 1 158 ? -1.951 -1.946 -70.975 1.00 29.07 ? 189 PRO A CB 1 ATOM 1274 C CG . PRO A 1 158 ? -1.507 -0.972 -69.944 1.00 32.08 ? 189 PRO A CG 1 ATOM 1275 C CD . PRO A 1 158 ? -2.373 -1.217 -68.741 1.00 34.55 ? 189 PRO A CD 1 ATOM 1276 N N . ASP A 1 159 ? -0.999 -5.061 -70.974 1.00 35.40 ? 190 ASP A N 1 ATOM 1277 C CA . ASP A 1 159 ? 0.128 -5.982 -70.999 1.00 34.61 ? 190 ASP A CA 1 ATOM 1278 C C . ASP A 1 159 ? 1.377 -5.281 -71.520 1.00 37.21 ? 190 ASP A C 1 ATOM 1279 O O . ASP A 1 159 ? 1.375 -4.747 -72.629 1.00 38.12 ? 190 ASP A O 1 ATOM 1280 C CB . ASP A 1 159 ? -0.197 -7.204 -71.864 1.00 33.32 ? 190 ASP A CB 1 ATOM 1281 C CG . ASP A 1 159 ? 1.031 -8.045 -72.179 1.00 42.39 ? 190 ASP A CG 1 ATOM 1282 O OD1 . ASP A 1 159 ? 1.943 -8.127 -71.331 1.00 40.30 ? 190 ASP A OD1 1 ATOM 1283 O OD2 . ASP A 1 159 ? 1.085 -8.631 -73.281 1.00 40.59 ? 190 ASP A OD2 1 ATOM 1284 N N . PRO A 1 160 ? 2.450 -5.280 -70.714 1.00 33.06 ? 191 PRO A N 1 ATOM 1285 C CA . PRO A 1 160 ? 3.745 -4.720 -71.119 1.00 29.38 ? 191 PRO A CA 1 ATOM 1286 C C . PRO A 1 160 ? 4.327 -5.377 -72.372 1.00 33.54 ? 191 PRO A C 1 ATOM 1287 O O . PRO A 1 160 ? 5.030 -4.706 -73.127 1.00 38.47 ? 191 PRO A O 1 ATOM 1288 C CB . PRO A 1 160 ? 4.644 -4.986 -69.902 1.00 33.56 ? 191 PRO A CB 1 ATOM 1289 C CG . PRO A 1 160 ? 3.918 -6.003 -69.080 1.00 38.60 ? 191 PRO A CG 1 ATOM 1290 C CD . PRO A 1 160 ? 2.468 -5.746 -69.318 1.00 31.30 ? 191 PRO A CD 1 ATOM 1291 N N . GLN A 1 161 ? 4.042 -6.658 -72.591 1.00 32.70 ? 192 GLN A N 1 ATOM 1292 C CA . GLN A 1 161 ? 4.588 -7.368 -73.747 1.00 36.13 ? 192 GLN A CA 1 ATOM 1293 C C . GLN A 1 161 ? 3.858 -7.000 -75.039 1.00 35.87 ? 192 GLN A C 1 ATOM 1294 O O . GLN A 1 161 ? 4.312 -7.330 -76.134 1.00 34.52 ? 192 GLN A O 1 ATOM 1295 C CB . GLN A 1 161 ? 4.538 -8.881 -73.521 1.00 30.06 ? 192 GLN A CB 1 ATOM 1296 C CG . GLN A 1 161 ? 5.451 -9.360 -72.402 1.00 37.79 ? 192 GLN A CG 1 ATOM 1297 C CD . GLN A 1 161 ? 5.493 -10.871 -72.278 1.00 38.71 ? 192 GLN A CD 1 ATOM 1298 O OE1 . GLN A 1 161 ? 5.246 -11.422 -71.205 1.00 40.90 ? 192 GLN A OE1 1 ATOM 1299 N NE2 . GLN A 1 161 ? 5.817 -11.549 -73.374 1.00 35.24 ? 192 GLN A NE2 1 ATOM 1300 N N . GLY A 1 162 ? 2.725 -6.318 -74.906 1.00 29.97 ? 193 GLY A N 1 ATOM 1301 C CA . GLY A 1 162 ? 2.027 -5.778 -76.057 1.00 32.37 ? 193 GLY A CA 1 ATOM 1302 C C . GLY A 1 162 ? 1.061 -6.720 -76.750 1.00 35.72 ? 193 GLY A C 1 ATOM 1303 O O . GLY A 1 162 ? 0.726 -6.509 -77.916 1.00 36.26 ? 193 GLY A O 1 ATOM 1304 N N . SER A 1 163 ? 0.605 -7.751 -76.042 1.00 34.84 ? 194 SER A N 1 ATOM 1305 C CA . SER A 1 163 ? -0.341 -8.712 -76.607 1.00 32.36 ? 194 SER A CA 1 ATOM 1306 C C . SER A 1 163 ? -1.645 -8.031 -77.018 1.00 34.88 ? 194 SER A C 1 ATOM 1307 O O . SER A 1 163 ? -2.284 -7.358 -76.210 1.00 31.15 ? 194 SER A O 1 ATOM 1308 C CB . SER A 1 163 ? -0.631 -9.837 -75.607 1.00 36.70 ? 194 SER A CB 1 ATOM 1309 O OG . SER A 1 163 ? 0.561 -10.476 -75.185 1.00 31.84 ? 194 SER A OG 1 ATOM 1310 N N . ASN A 1 164 ? -2.032 -8.206 -78.278 1.00 33.57 ? 195 ASN A N 1 ATOM 1311 C CA . ASN A 1 164 ? -3.238 -7.570 -78.796 1.00 31.45 ? 195 ASN A CA 1 ATOM 1312 C C . ASN A 1 164 ? -4.445 -8.500 -78.771 1.00 34.28 ? 195 ASN A C 1 ATOM 1313 O O . ASN A 1 164 ? -4.374 -9.605 -78.235 1.00 34.23 ? 195 ASN A O 1 ATOM 1314 C CB . ASN A 1 164 ? -3.003 -7.054 -80.220 1.00 27.95 ? 195 ASN A CB 1 ATOM 1315 C CG . ASN A 1 164 ? -2.436 -8.112 -81.146 1.00 29.55 ? 195 ASN A CG 1 ATOM 1316 O OD1 . ASN A 1 164 ? -2.681 -9.306 -80.977 1.00 30.22 ? 195 ASN A OD1 1 ATOM 1317 N ND2 . ASN A 1 164 ? -1.667 -7.674 -82.136 1.00 28.49 ? 195 ASN A ND2 1 ATOM 1318 N N . MET A 1 165 ? -5.550 -8.047 -79.356 1.00 35.14 ? 196 MET A N 1 ATOM 1319 C CA . MET A 1 165 ? -6.779 -8.830 -79.371 1.00 30.28 ? 196 MET A CA 1 ATOM 1320 C C . MET A 1 165 ? -6.722 -9.935 -80.420 1.00 34.33 ? 196 MET A C 1 ATOM 1321 O O . MET A 1 165 ? -7.501 -10.886 -80.370 1.00 43.53 ? 196 MET A O 1 ATOM 1322 C CB . MET A 1 165 ? -7.989 -7.927 -79.612 1.00 33.30 ? 196 MET A CB 1 ATOM 1323 C CG . MET A 1 165 ? -8.256 -6.965 -78.471 1.00 36.79 ? 196 MET A CG 1 ATOM 1324 S SD . MET A 1 165 ? -8.395 -7.817 -76.888 1.00 37.31 ? 196 MET A SD 1 ATOM 1325 C CE . MET A 1 165 ? -10.026 -8.533 -77.035 1.00 43.73 ? 196 MET A CE 1 ATOM 1326 N N . MET A 1 166 ? -5.802 -9.811 -81.371 1.00 29.26 ? 197 MET A N 1 ATOM 1327 C CA . MET A 1 166 ? -5.538 -10.908 -82.294 1.00 33.81 ? 197 MET A CA 1 ATOM 1328 C C . MET A 1 166 ? -4.986 -12.083 -81.501 1.00 37.53 ? 197 MET A C 1 ATOM 1329 O O . MET A 1 166 ? -5.272 -13.239 -81.801 1.00 35.73 ? 197 MET A O 1 ATOM 1330 C CB . MET A 1 166 ? -4.556 -10.495 -83.392 1.00 27.53 ? 197 MET A CB 1 ATOM 1331 C CG . MET A 1 166 ? -5.111 -9.486 -84.380 1.00 33.28 ? 197 MET A CG 1 ATOM 1332 S SD . MET A 1 166 ? -6.512 -10.121 -85.314 1.00 40.82 ? 197 MET A SD 1 ATOM 1333 C CE . MET A 1 166 ? -5.723 -11.414 -86.268 1.00 28.01 ? 197 MET A CE 1 ATOM 1334 N N . PHE A 1 167 ? -4.194 -11.766 -80.481 1.00 32.08 ? 198 PHE A N 1 ATOM 1335 C CA . PHE A 1 167 ? -3.630 -12.769 -79.588 1.00 29.36 ? 198 PHE A CA 1 ATOM 1336 C C . PHE A 1 167 ? -4.691 -13.336 -78.657 1.00 34.18 ? 198 PHE A C 1 ATOM 1337 O O . PHE A 1 167 ? -4.849 -14.552 -78.545 1.00 35.75 ? 198 PHE A O 1 ATOM 1338 C CB . PHE A 1 167 ? -2.483 -12.166 -78.772 1.00 32.02 ? 198 PHE A CB 1 ATOM 1339 C CG . PHE A 1 167 ? -1.977 -13.059 -77.672 1.00 31.95 ? 198 PHE A CG 1 ATOM 1340 C CD1 . PHE A 1 167 ? -2.491 -12.964 -76.386 1.00 30.67 ? 198 PHE A CD1 1 ATOM 1341 C CD2 . PHE A 1 167 ? -0.975 -13.982 -77.920 1.00 33.98 ? 198 PHE A CD2 1 ATOM 1342 C CE1 . PHE A 1 167 ? -2.023 -13.783 -75.376 1.00 35.49 ? 198 PHE A CE1 1 ATOM 1343 C CE2 . PHE A 1 167 ? -0.502 -14.800 -76.912 1.00 36.30 ? 198 PHE A CE2 1 ATOM 1344 C CZ . PHE A 1 167 ? -1.026 -14.700 -75.640 1.00 37.42 ? 198 PHE A CZ 1 ATOM 1345 N N . ALA A 1 168 ? -5.407 -12.443 -77.982 1.00 28.20 ? 199 ALA A N 1 ATOM 1346 C CA . ALA A 1 168 ? -6.396 -12.834 -76.986 1.00 28.45 ? 199 ALA A CA 1 ATOM 1347 C C . ALA A 1 168 ? -7.469 -13.744 -77.572 1.00 34.49 ? 199 ALA A C 1 ATOM 1348 O O . ALA A 1 168 ? -7.875 -14.721 -76.941 1.00 33.32 ? 199 ALA A O 1 ATOM 1349 C CB . ALA A 1 168 ? -7.033 -11.604 -76.369 1.00 26.83 ? 199 ALA A CB 1 ATOM 1350 N N . PHE A 1 169 ? -7.923 -13.425 -78.779 1.00 31.36 ? 200 PHE A N 1 ATOM 1351 C CA . PHE A 1 169 ? -8.967 -14.215 -79.418 1.00 34.84 ? 200 PHE A CA 1 ATOM 1352 C C . PHE A 1 169 ? -8.408 -15.496 -80.026 1.00 38.65 ? 200 PHE A C 1 ATOM 1353 O O . PHE A 1 169 ? -9.107 -16.506 -80.096 1.00 40.13 ? 200 PHE A O 1 ATOM 1354 C CB . PHE A 1 169 ? -9.694 -13.389 -80.480 1.00 30.99 ? 200 PHE A CB 1 ATOM 1355 C CG . PHE A 1 169 ? -10.702 -12.434 -79.908 1.00 38.15 ? 200 PHE A CG 1 ATOM 1356 C CD1 . PHE A 1 169 ? -11.722 -12.897 -79.093 1.00 40.42 ? 200 PHE A CD1 1 ATOM 1357 C CD2 . PHE A 1 169 ? -10.635 -11.078 -80.184 1.00 42.11 ? 200 PHE A CD2 1 ATOM 1358 C CE1 . PHE A 1 169 ? -12.652 -12.028 -78.560 1.00 36.40 ? 200 PHE A CE1 1 ATOM 1359 C CE2 . PHE A 1 169 ? -11.564 -10.205 -79.655 1.00 38.24 ? 200 PHE A CE2 1 ATOM 1360 C CZ . PHE A 1 169 ? -12.574 -10.680 -78.840 1.00 34.74 ? 200 PHE A CZ 1 ATOM 1361 N N . PHE A 1 170 ? -7.150 -15.464 -80.457 1.00 34.06 ? 201 PHE A N 1 ATOM 1362 C CA . PHE A 1 170 ? -6.497 -16.682 -80.926 1.00 35.83 ? 201 PHE A CA 1 ATOM 1363 C C . PHE A 1 170 ? -6.347 -17.663 -79.773 1.00 34.97 ? 201 PHE A C 1 ATOM 1364 O O . PHE A 1 170 ? -6.609 -18.852 -79.920 1.00 36.62 ? 201 PHE A O 1 ATOM 1365 C CB . PHE A 1 170 ? -5.129 -16.379 -81.535 1.00 30.79 ? 201 PHE A CB 1 ATOM 1366 C CG . PHE A 1 170 ? -4.473 -17.571 -82.179 1.00 33.99 ? 201 PHE A CG 1 ATOM 1367 C CD1 . PHE A 1 170 ? -3.657 -18.421 -81.444 1.00 32.76 ? 201 PHE A CD1 1 ATOM 1368 C CD2 . PHE A 1 170 ? -4.669 -17.839 -83.523 1.00 33.92 ? 201 PHE A CD2 1 ATOM 1369 C CE1 . PHE A 1 170 ? -3.055 -19.515 -82.040 1.00 31.79 ? 201 PHE A CE1 1 ATOM 1370 C CE2 . PHE A 1 170 ? -4.069 -18.930 -84.123 1.00 32.27 ? 201 PHE A CE2 1 ATOM 1371 C CZ . PHE A 1 170 ? -3.261 -19.768 -83.380 1.00 31.18 ? 201 PHE A CZ 1 ATOM 1372 N N . ALA A 1 171 ? -5.919 -17.147 -78.626 1.00 35.26 ? 202 ALA A N 1 ATOM 1373 C CA . ALA A 1 171 ? -5.753 -17.957 -77.426 1.00 34.61 ? 202 ALA A CA 1 ATOM 1374 C C . ALA A 1 171 ? -7.056 -18.643 -77.037 1.00 36.04 ? 202 ALA A C 1 ATOM 1375 O O . ALA A 1 171 ? -7.069 -19.829 -76.712 1.00 37.54 ? 202 ALA A O 1 ATOM 1376 C CB . ALA A 1 171 ? -5.246 -17.103 -76.277 1.00 25.79 ? 202 ALA A CB 1 ATOM 1377 N N . GLN A 1 172 ? -8.155 -17.898 -77.079 1.00 37.35 ? 203 GLN A N 1 ATOM 1378 C CA . GLN A 1 172 ? -9.443 -18.448 -76.680 1.00 39.52 ? 203 GLN A CA 1 ATOM 1379 C C . GLN A 1 172 ? -9.989 -19.399 -77.740 1.00 39.78 ? 203 GLN A C 1 ATOM 1380 O O . GLN A 1 172 ? -10.617 -20.401 -77.412 1.00 47.05 ? 203 GLN A O 1 ATOM 1381 C CB . GLN A 1 172 ? -10.457 -17.336 -76.408 1.00 32.21 ? 203 GLN A CB 1 ATOM 1382 C CG . GLN A 1 172 ? -11.609 -17.792 -75.525 1.00 52.53 ? 203 GLN A CG 1 ATOM 1383 C CD . GLN A 1 172 ? -12.794 -16.850 -75.559 1.00 79.57 ? 203 GLN A CD 1 ATOM 1384 O OE1 . GLN A 1 172 ? -12.726 -15.765 -76.137 1.00 69.48 ? 203 GLN A OE1 1 ATOM 1385 N NE2 . GLN A 1 172 ? -13.895 -17.266 -74.942 1.00 78.69 ? 203 GLN A NE2 1 ATOM 1386 N N . HIS A 1 173 ? -9.749 -19.084 -79.009 1.00 35.17 ? 204 HIS A N 1 ATOM 1387 C CA . HIS A 1 173 ? -10.213 -19.931 -80.103 1.00 33.42 ? 204 HIS A CA 1 ATOM 1388 C C . HIS A 1 173 ? -9.439 -21.245 -80.140 1.00 35.91 ? 204 HIS A C 1 ATOM 1389 O O . HIS A 1 173 ? -10.022 -22.317 -80.285 1.00 37.03 ? 204 HIS A O 1 ATOM 1390 C CB . HIS A 1 173 ? -10.082 -19.204 -81.445 1.00 30.98 ? 204 HIS A CB 1 ATOM 1391 C CG . HIS A 1 173 ? -10.506 -20.025 -82.623 1.00 31.05 ? 204 HIS A CG 1 ATOM 1392 N ND1 . HIS A 1 173 ? -9.615 -20.753 -83.383 1.00 31.61 ? 204 HIS A ND1 1 ATOM 1393 C CD2 . HIS A 1 173 ? -11.725 -20.228 -83.177 1.00 30.93 ? 204 HIS A CD2 1 ATOM 1394 C CE1 . HIS A 1 173 ? -10.267 -21.371 -84.352 1.00 28.88 ? 204 HIS A CE1 1 ATOM 1395 N NE2 . HIS A 1 173 ? -11.550 -21.070 -84.249 1.00 31.55 ? 204 HIS A NE2 1 ATOM 1396 N N . PHE A 1 174 ? -8.121 -21.152 -79.997 1.00 34.69 ? 205 PHE A N 1 ATOM 1397 C CA . PHE A 1 174 ? -7.251 -22.321 -80.061 1.00 32.25 ? 205 PHE A CA 1 ATOM 1398 C C . PHE A 1 174 ? -7.468 -23.293 -78.903 1.00 35.85 ? 205 PHE A C 1 ATOM 1399 O O . PHE A 1 174 ? -7.645 -24.489 -79.120 1.00 38.16 ? 205 PHE A O 1 ATOM 1400 C CB . PHE A 1 174 ? -5.784 -21.884 -80.097 1.00 31.76 ? 205 PHE A CB 1 ATOM 1401 C CG . PHE A 1 174 ? -4.810 -23.004 -79.870 1.00 31.04 ? 205 PHE A CG 1 ATOM 1402 C CD1 . PHE A 1 174 ? -4.622 -23.983 -80.831 1.00 29.02 ? 205 PHE A CD1 1 ATOM 1403 C CD2 . PHE A 1 174 ? -4.069 -23.068 -78.700 1.00 29.92 ? 205 PHE A CD2 1 ATOM 1404 C CE1 . PHE A 1 174 ? -3.722 -25.013 -80.625 1.00 32.22 ? 205 PHE A CE1 1 ATOM 1405 C CE2 . PHE A 1 174 ? -3.167 -24.093 -78.489 1.00 36.22 ? 205 PHE A CE2 1 ATOM 1406 C CZ . PHE A 1 174 ? -2.993 -25.066 -79.453 1.00 35.96 ? 205 PHE A CZ 1 ATOM 1407 N N . THR A 1 175 ? -7.455 -22.783 -77.676 1.00 36.56 ? 206 THR A N 1 ATOM 1408 C CA . THR A 1 175 ? -7.523 -23.649 -76.503 1.00 33.76 ? 206 THR A CA 1 ATOM 1409 C C . THR A 1 175 ? -8.924 -24.196 -76.247 1.00 34.35 ? 206 THR A C 1 ATOM 1410 O O . THR A 1 175 ? -9.093 -25.124 -75.457 1.00 42.63 ? 206 THR A O 1 ATOM 1411 C CB . THR A 1 175 ? -7.040 -22.921 -75.231 1.00 27.66 ? 206 THR A CB 1 ATOM 1412 O OG1 . THR A 1 175 ? -7.887 -21.798 -74.963 1.00 31.62 ? 206 THR A OG1 1 ATOM 1413 C CG2 . THR A 1 175 ? -5.609 -22.447 -75.407 1.00 27.63 ? 206 THR A CG2 1 ATOM 1414 N N . HIS A 1 176 ? -9.925 -23.637 -76.918 1.00 36.43 ? 207 HIS A N 1 ATOM 1415 C CA . HIS A 1 176 ? -11.300 -24.096 -76.730 1.00 41.72 ? 207 HIS A CA 1 ATOM 1416 C C . HIS A 1 176 ? -11.585 -25.398 -77.471 1.00 40.21 ? 207 HIS A C 1 ATOM 1417 O O . HIS A 1 176 ? -12.719 -25.871 -77.485 1.00 48.35 ? 207 HIS A O 1 ATOM 1418 C CB . HIS A 1 176 ? -12.297 -23.025 -77.178 1.00 45.12 ? 207 HIS A CB 1 ATOM 1419 C CG . HIS A 1 176 ? -13.031 -22.377 -76.046 1.00 70.48 ? 207 HIS A CG 1 ATOM 1420 N ND1 . HIS A 1 176 ? -12.631 -22.499 -74.733 1.00 73.65 ? 207 HIS A ND1 1 ATOM 1421 C CD2 . HIS A 1 176 ? -14.145 -21.606 -76.031 1.00 71.01 ? 207 HIS A CD2 1 ATOM 1422 C CE1 . HIS A 1 176 ? -13.465 -21.829 -73.958 1.00 92.35 ? 207 HIS A CE1 1 ATOM 1423 N NE2 . HIS A 1 176 ? -14.391 -21.278 -74.720 1.00 101.71 ? 207 HIS A NE2 1 ATOM 1424 N N . GLN A 1 177 ? -10.559 -25.976 -78.086 1.00 33.91 ? 208 GLN A N 1 ATOM 1425 C CA . GLN A 1 177 ? -10.719 -27.255 -78.762 1.00 36.03 ? 208 GLN A CA 1 ATOM 1426 C C . GLN A 1 177 ? -10.359 -28.405 -77.827 1.00 34.32 ? 208 GLN A C 1 ATOM 1427 O O . GLN A 1 177 ? -10.787 -29.538 -78.045 1.00 36.76 ? 208 GLN A O 1 ATOM 1428 C CB . GLN A 1 177 ? -9.869 -27.318 -80.034 1.00 32.44 ? 208 GLN A CB 1 ATOM 1429 C CG . GLN A 1 177 ? -8.384 -27.492 -79.791 1.00 30.48 ? 208 GLN A CG 1 ATOM 1430 C CD . GLN A 1 177 ? -7.576 -27.386 -81.067 1.00 28.54 ? 208 GLN A CD 1 ATOM 1431 O OE1 . GLN A 1 177 ? -7.544 -28.313 -81.874 1.00 30.93 ? 208 GLN A OE1 1 ATOM 1432 N NE2 . GLN A 1 177 ? -6.923 -26.246 -81.261 1.00 32.96 ? 208 GLN A NE2 1 ATOM 1433 N N . PHE A 1 178 ? -9.578 -28.116 -76.786 1.00 33.99 ? 209 PHE A N 1 ATOM 1434 C CA . PHE A 1 178 ? -9.275 -29.130 -75.781 1.00 36.88 ? 209 PHE A CA 1 ATOM 1435 C C . PHE A 1 178 ? -9.640 -28.682 -74.364 1.00 33.75 ? 209 PHE A C 1 ATOM 1436 O O . PHE A 1 178 ? -9.404 -29.406 -73.398 1.00 36.78 ? 209 PHE A O 1 ATOM 1437 C CB . PHE A 1 178 ? -7.797 -29.549 -75.846 1.00 32.29 ? 209 PHE A CB 1 ATOM 1438 C CG . PHE A 1 178 ? -6.824 -28.405 -75.929 1.00 32.01 ? 209 PHE A CG 1 ATOM 1439 C CD1 . PHE A 1 178 ? -6.555 -27.615 -74.821 1.00 30.90 ? 209 PHE A CD1 1 ATOM 1440 C CD2 . PHE A 1 178 ? -6.141 -28.150 -77.108 1.00 29.46 ? 209 PHE A CD2 1 ATOM 1441 C CE1 . PHE A 1 178 ? -5.645 -26.574 -74.898 1.00 29.76 ? 209 PHE A CE1 1 ATOM 1442 C CE2 . PHE A 1 178 ? -5.229 -27.110 -77.191 1.00 29.10 ? 209 PHE A CE2 1 ATOM 1443 C CZ . PHE A 1 178 ? -4.980 -26.321 -76.085 1.00 24.15 ? 209 PHE A CZ 1 ATOM 1444 N N . PHE A 1 179 ? -10.225 -27.494 -74.242 1.00 33.25 ? 210 PHE A N 1 ATOM 1445 C CA . PHE A 1 179 ? -10.806 -27.063 -72.972 1.00 34.51 ? 210 PHE A CA 1 ATOM 1446 C C . PHE A 1 179 ? -12.325 -26.986 -73.089 1.00 36.19 ? 210 PHE A C 1 ATOM 1447 O O . PHE A 1 179 ? -12.903 -25.901 -73.089 1.00 47.36 ? 210 PHE A O 1 ATOM 1448 C CB . PHE A 1 179 ? -10.247 -25.707 -72.531 1.00 31.56 ? 210 PHE A CB 1 ATOM 1449 C CG . PHE A 1 179 ? -8.817 -25.756 -72.078 1.00 31.34 ? 210 PHE A CG 1 ATOM 1450 C CD1 . PHE A 1 179 ? -8.267 -26.933 -71.596 1.00 37.00 ? 210 PHE A CD1 1 ATOM 1451 C CD2 . PHE A 1 179 ? -8.021 -24.623 -72.133 1.00 28.76 ? 210 PHE A CD2 1 ATOM 1452 C CE1 . PHE A 1 179 ? -6.949 -26.978 -71.180 1.00 37.53 ? 210 PHE A CE1 1 ATOM 1453 C CE2 . PHE A 1 179 ? -6.704 -24.663 -71.718 1.00 32.09 ? 210 PHE A CE2 1 ATOM 1454 C CZ . PHE A 1 179 ? -6.167 -25.840 -71.241 1.00 33.83 ? 210 PHE A CZ 1 ATOM 1455 N N . LYS A 1 180 ? -12.966 -28.145 -73.193 1.00 32.91 ? 211 LYS A N 1 ATOM 1456 C CA . LYS A 1 180 ? -14.414 -28.202 -73.340 1.00 32.02 ? 211 LYS A CA 1 ATOM 1457 C C . LYS A 1 180 ? -15.040 -28.903 -72.144 1.00 40.47 ? 211 LYS A C 1 ATOM 1458 O O . LYS A 1 180 ? -15.421 -30.069 -72.226 1.00 46.42 ? 211 LYS A O 1 ATOM 1459 C CB . LYS A 1 180 ? -14.792 -28.913 -74.640 1.00 36.59 ? 211 LYS A CB 1 ATOM 1460 C CG . LYS A 1 180 ? -14.035 -28.397 -75.855 1.00 42.30 ? 211 LYS A CG 1 ATOM 1461 C CD . LYS A 1 180 ? -14.711 -28.793 -77.154 1.00 40.70 ? 211 LYS A CD 1 ATOM 1462 C CE . LYS A 1 180 ? -14.802 -30.298 -77.295 1.00 34.66 ? 211 LYS A CE 1 ATOM 1463 N NZ . LYS A 1 180 ? -15.468 -30.686 -78.566 1.00 35.67 ? 211 LYS A NZ 1 ATOM 1464 N N . THR A 1 181 ? -15.138 -28.179 -71.034 1.00 40.19 ? 212 THR A N 1 ATOM 1465 C CA . THR A 1 181 ? -15.646 -28.735 -69.784 1.00 39.21 ? 212 THR A CA 1 ATOM 1466 C C . THR A 1 181 ? -17.089 -29.218 -69.906 1.00 48.34 ? 212 THR A C 1 ATOM 1467 O O . THR A 1 181 ? -17.973 -28.479 -70.334 1.00 48.75 ? 212 THR A O 1 ATOM 1468 C CB . THR A 1 181 ? -15.553 -27.706 -68.637 1.00 46.55 ? 212 THR A CB 1 ATOM 1469 O OG1 . THR A 1 181 ? -14.175 -27.429 -68.352 1.00 44.31 ? 212 THR A OG1 1 ATOM 1470 C CG2 . THR A 1 181 ? -16.220 -28.241 -67.381 1.00 49.46 ? 212 THR A CG2 1 ATOM 1471 N N . ASP A 1 182 ? -17.310 -30.475 -69.532 1.00 53.05 ? 213 ASP A N 1 ATOM 1472 C CA . ASP A 1 182 ? -18.641 -31.068 -69.518 1.00 49.50 ? 213 ASP A CA 1 ATOM 1473 C C . ASP A 1 182 ? -19.339 -30.720 -68.209 1.00 55.08 ? 213 ASP A C 1 ATOM 1474 O O . ASP A 1 182 ? -19.158 -31.405 -67.204 1.00 59.47 ? 213 ASP A O 1 ATOM 1475 C CB . ASP A 1 182 ? -18.552 -32.586 -69.691 1.00 45.69 ? 213 ASP A CB 1 ATOM 1476 C CG . ASP A 1 182 ? -19.897 -33.225 -69.981 1.00 56.56 ? 213 ASP A CG 1 ATOM 1477 O OD1 . ASP A 1 182 ? -20.924 -32.514 -69.942 1.00 60.55 ? 213 ASP A OD1 1 ATOM 1478 O OD2 . ASP A 1 182 ? -19.928 -34.446 -70.245 1.00 55.64 ? 213 ASP A OD2 1 ATOM 1479 N N . HIS A 1 183 ? -20.142 -29.661 -68.224 1.00 57.30 ? 214 HIS A N 1 ATOM 1480 C CA . HIS A 1 183 ? -20.750 -29.153 -66.997 1.00 64.94 ? 214 HIS A CA 1 ATOM 1481 C C . HIS A 1 183 ? -21.946 -29.978 -66.530 1.00 68.29 ? 214 HIS A C 1 ATOM 1482 O O . HIS A 1 183 ? -22.442 -29.784 -65.420 1.00 63.96 ? 214 HIS A O 1 ATOM 1483 C CB . HIS A 1 183 ? -21.157 -27.692 -67.177 1.00 65.70 ? 214 HIS A CB 1 ATOM 1484 C CG . HIS A 1 183 ? -20.023 -26.731 -67.002 1.00 83.84 ? 214 HIS A CG 1 ATOM 1485 N ND1 . HIS A 1 183 ? -19.467 -26.031 -68.051 1.00 80.26 ? 214 HIS A ND1 1 ATOM 1486 C CD2 . HIS A 1 183 ? -19.328 -26.369 -65.898 1.00 79.14 ? 214 HIS A CD2 1 ATOM 1487 C CE1 . HIS A 1 183 ? -18.485 -25.271 -67.600 1.00 81.88 ? 214 HIS A CE1 1 ATOM 1488 N NE2 . HIS A 1 183 ? -18.380 -25.458 -66.296 1.00 89.86 ? 214 HIS A NE2 1 ATOM 1489 N N . LYS A 1 184 ? -22.407 -30.896 -67.371 1.00 69.36 ? 215 LYS A N 1 ATOM 1490 C CA . LYS A 1 184 ? -23.434 -31.842 -66.955 1.00 60.35 ? 215 LYS A CA 1 ATOM 1491 C C . LYS A 1 184 ? -22.869 -32.790 -65.905 1.00 61.17 ? 215 LYS A C 1 ATOM 1492 O O . LYS A 1 184 ? -23.558 -33.168 -64.959 1.00 67.06 ? 215 LYS A O 1 ATOM 1493 C CB . LYS A 1 184 ? -23.967 -32.634 -68.149 1.00 68.78 ? 215 LYS A CB 1 ATOM 1494 C CG . LYS A 1 184 ? -24.977 -31.885 -69.004 1.00 86.88 ? 215 LYS A CG 1 ATOM 1495 C CD . LYS A 1 184 ? -24.517 -31.790 -70.451 1.00 101.42 ? 215 LYS A CD 1 ATOM 1496 C CE . LYS A 1 184 ? -24.035 -33.138 -70.974 1.00 99.10 ? 215 LYS A CE 1 ATOM 1497 N NZ . LYS A 1 184 ? -25.090 -34.186 -70.901 1.00 94.58 ? 215 LYS A NZ 1 ATOM 1498 N N . ARG A 1 185 ? -21.605 -33.164 -66.078 1.00 55.41 ? 216 ARG A N 1 ATOM 1499 C CA . ARG A 1 185 ? -20.945 -34.090 -65.165 1.00 47.72 ? 216 ARG A CA 1 ATOM 1500 C C . ARG A 1 185 ? -20.218 -33.356 -64.044 1.00 49.19 ? 216 ARG A C 1 ATOM 1501 O O . ARG A 1 185 ? -20.312 -33.739 -62.877 1.00 51.60 ? 216 ARG A O 1 ATOM 1502 C CB . ARG A 1 185 ? -19.958 -34.977 -65.923 1.00 46.26 ? 216 ARG A CB 1 ATOM 1503 C CG . ARG A 1 185 ? -20.573 -35.783 -67.054 1.00 45.88 ? 216 ARG A CG 1 ATOM 1504 C CD . ARG A 1 185 ? -19.558 -36.761 -67.621 1.00 48.30 ? 216 ARG A CD 1 ATOM 1505 N NE . ARG A 1 185 ? -20.031 -37.415 -68.836 1.00 57.14 ? 216 ARG A NE 1 ATOM 1506 C CZ . ARG A 1 185 ? -20.682 -38.573 -68.856 1.00 61.99 ? 216 ARG A CZ 1 ATOM 1507 N NH1 . ARG A 1 185 ? -20.943 -39.209 -67.722 1.00 51.31 ? 216 ARG A NH1 1 ATOM 1508 N NH2 . ARG A 1 185 ? -21.072 -39.094 -70.011 1.00 62.75 ? 216 ARG A NH2 1 ATOM 1509 N N . GLY A 1 186 ? -19.486 -32.307 -64.404 1.00 44.79 ? 217 GLY A N 1 ATOM 1510 C CA . GLY A 1 186 ? -18.727 -31.544 -63.432 1.00 39.81 ? 217 GLY A CA 1 ATOM 1511 C C . GLY A 1 186 ? -17.514 -30.870 -64.044 1.00 42.09 ? 217 GLY A C 1 ATOM 1512 O O . GLY A 1 186 ? -17.188 -31.104 -65.207 1.00 46.31 ? 217 GLY A O 1 ATOM 1513 N N . PRO A 1 187 ? -16.829 -30.029 -63.256 1.00 40.59 ? 218 PRO A N 1 ATOM 1514 C CA . PRO A 1 187 ? -15.664 -29.273 -63.730 1.00 42.52 ? 218 PRO A CA 1 ATOM 1515 C C . PRO A 1 187 ? -14.454 -30.158 -64.025 1.00 42.86 ? 218 PRO A C 1 ATOM 1516 O O . PRO A 1 187 ? -13.521 -29.712 -64.695 1.00 46.78 ? 218 PRO A O 1 ATOM 1517 C CB . PRO A 1 187 ? -15.369 -28.324 -62.565 1.00 45.19 ? 218 PRO A CB 1 ATOM 1518 C CG . PRO A 1 187 ? -15.900 -29.026 -61.370 1.00 43.24 ? 218 PRO A CG 1 ATOM 1519 C CD . PRO A 1 187 ? -17.123 -29.758 -61.838 1.00 36.76 ? 218 PRO A CD 1 ATOM 1520 N N . GLY A 1 188 ? -14.473 -31.392 -63.533 1.00 42.26 ? 219 GLY A N 1 ATOM 1521 C CA . GLY A 1 188 ? -13.367 -32.308 -63.741 1.00 37.65 ? 219 GLY A CA 1 ATOM 1522 C C . GLY A 1 188 ? -13.536 -33.167 -64.980 1.00 37.34 ? 219 GLY A C 1 ATOM 1523 O O . GLY A 1 188 ? -12.735 -34.069 -65.230 1.00 31.72 ? 219 GLY A O 1 ATOM 1524 N N . PHE A 1 189 ? -14.576 -32.885 -65.760 1.00 32.23 ? 220 PHE A N 1 ATOM 1525 C CA . PHE A 1 189 ? -14.864 -33.667 -66.957 1.00 35.56 ? 220 PHE A CA 1 ATOM 1526 C C . PHE A 1 189 ? -14.800 -32.825 -68.228 1.00 39.04 ? 220 PHE A C 1 ATOM 1527 O O . PHE A 1 189 ? -14.980 -31.608 -68.187 1.00 35.11 ? 220 PHE A O 1 ATOM 1528 C CB . PHE A 1 189 ? -16.239 -34.330 -66.843 1.00 38.17 ? 220 PHE A CB 1 ATOM 1529 C CG . PHE A 1 189 ? -16.319 -35.371 -65.766 1.00 38.42 ? 220 PHE A CG 1 ATOM 1530 C CD1 . PHE A 1 189 ? -16.728 -35.034 -64.487 1.00 40.51 ? 220 PHE A CD1 1 ATOM 1531 C CD2 . PHE A 1 189 ? -15.980 -36.686 -66.032 1.00 39.66 ? 220 PHE A CD2 1 ATOM 1532 C CE1 . PHE A 1 189 ? -16.802 -35.988 -63.494 1.00 39.73 ? 220 PHE A CE1 1 ATOM 1533 C CE2 . PHE A 1 189 ? -16.050 -37.646 -65.042 1.00 39.25 ? 220 PHE A CE2 1 ATOM 1534 C CZ . PHE A 1 189 ? -16.463 -37.297 -63.771 1.00 40.48 ? 220 PHE A CZ 1 ATOM 1535 N N . THR A 1 190 ? -14.547 -33.486 -69.354 1.00 35.67 ? 221 THR A N 1 ATOM 1536 C CA . THR A 1 190 ? -14.390 -32.801 -70.632 1.00 36.42 ? 221 THR A CA 1 ATOM 1537 C C . THR A 1 190 ? -15.192 -33.477 -71.739 1.00 38.07 ? 221 THR A C 1 ATOM 1538 O O . THR A 1 190 ? -15.523 -34.657 -71.642 1.00 39.56 ? 221 THR A O 1 ATOM 1539 C CB . THR A 1 190 ? -12.908 -32.742 -71.058 1.00 35.41 ? 221 THR A CB 1 ATOM 1540 O OG1 . THR A 1 190 ? -12.801 -32.101 -72.334 1.00 39.33 ? 221 THR A OG1 1 ATOM 1541 C CG2 . THR A 1 190 ? -12.319 -34.144 -71.155 1.00 31.68 ? 221 THR A CG2 1 ATOM 1542 N N . ARG A 1 191 ? -15.500 -32.723 -72.791 1.00 38.76 ? 222 ARG A N 1 ATOM 1543 C CA . ARG A 1 191 ? -16.179 -33.276 -73.960 1.00 37.68 ? 222 ARG A CA 1 ATOM 1544 C C . ARG A 1 191 ? -15.198 -33.473 -75.110 1.00 36.34 ? 222 ARG A C 1 ATOM 1545 O O . ARG A 1 191 ? -15.531 -34.083 -76.126 1.00 36.99 ? 222 ARG A O 1 ATOM 1546 C CB . ARG A 1 191 ? -17.327 -32.370 -74.410 1.00 36.50 ? 222 ARG A CB 1 ATOM 1547 C CG . ARG A 1 191 ? -18.410 -32.152 -73.370 1.00 42.21 ? 222 ARG A CG 1 ATOM 1548 C CD . ARG A 1 191 ? -19.620 -31.468 -73.985 1.00 53.68 ? 222 ARG A CD 1 ATOM 1549 N NE . ARG A 1 191 ? -19.231 -30.374 -74.869 1.00 81.94 ? 222 ARG A NE 1 ATOM 1550 C CZ . ARG A 1 191 ? -18.964 -29.137 -74.462 1.00 88.90 ? 222 ARG A CZ 1 ATOM 1551 N NH1 . ARG A 1 191 ? -18.616 -28.211 -75.346 1.00 70.18 ? 222 ARG A NH1 1 ATOM 1552 N NH2 . ARG A 1 191 ? -19.043 -28.824 -73.176 1.00 64.34 ? 222 ARG A NH2 1 ATOM 1553 N N . GLY A 1 192 ? -13.990 -32.941 -74.945 1.00 33.90 ? 223 GLY A N 1 ATOM 1554 C CA . GLY A 1 192 ? -12.951 -33.079 -75.948 1.00 33.49 ? 223 GLY A CA 1 ATOM 1555 C C . GLY A 1 192 ? -12.166 -34.361 -75.761 1.00 39.20 ? 223 GLY A C 1 ATOM 1556 O O . GLY A 1 192 ? -11.090 -34.362 -75.163 1.00 37.62 ? 223 GLY A O 1 ATOM 1557 N N . LEU A 1 193 ? -12.706 -35.458 -76.284 1.00 36.54 ? 224 LEU A N 1 ATOM 1558 C CA . LEU A 1 193 ? -12.118 -36.780 -76.088 1.00 30.06 ? 224 LEU A CA 1 ATOM 1559 C C . LEU A 1 193 ? -10.863 -36.995 -76.934 1.00 37.27 ? 224 LEU A C 1 ATOM 1560 O O . LEU A 1 193 ? -10.255 -38.066 -76.897 1.00 35.79 ? 224 LEU A O 1 ATOM 1561 C CB . LEU A 1 193 ? -13.155 -37.862 -76.394 1.00 28.78 ? 224 LEU A CB 1 ATOM 1562 C CG . LEU A 1 193 ? -14.433 -37.777 -75.554 1.00 33.71 ? 224 LEU A CG 1 ATOM 1563 C CD1 . LEU A 1 193 ? -15.399 -38.898 -75.903 1.00 15.55 ? 224 LEU A CD1 1 ATOM 1564 C CD2 . LEU A 1 193 ? -14.105 -37.799 -74.071 1.00 30.13 ? 224 LEU A CD2 1 ATOM 1565 N N . GLY A 1 194 ? -10.482 -35.975 -77.697 1.00 32.73 ? 225 GLY A N 1 ATOM 1566 C CA . GLY A 1 194 ? -9.246 -36.012 -78.456 1.00 21.96 ? 225 GLY A CA 1 ATOM 1567 C C . GLY A 1 194 ? -8.069 -35.625 -77.581 1.00 32.88 ? 225 GLY A C 1 ATOM 1568 O O . GLY A 1 194 ? -6.932 -36.025 -77.840 1.00 41.92 ? 225 GLY A O 1 ATOM 1569 N N . HIS A 1 195 ? -8.356 -34.845 -76.541 1.00 32.83 ? 226 HIS A N 1 ATOM 1570 C CA . HIS A 1 195 ? -7.354 -34.402 -75.571 1.00 36.41 ? 226 HIS A CA 1 ATOM 1571 C C . HIS A 1 195 ? -6.126 -33.762 -76.220 1.00 32.47 ? 226 HIS A C 1 ATOM 1572 O O . HIS A 1 195 ? -4.992 -34.020 -75.817 1.00 34.26 ? 226 HIS A O 1 ATOM 1573 C CB . HIS A 1 195 ? -6.921 -35.574 -74.682 1.00 29.19 ? 226 HIS A CB 1 ATOM 1574 C CG . HIS A 1 195 ? -7.916 -35.922 -73.619 1.00 33.31 ? 226 HIS A CG 1 ATOM 1575 N ND1 . HIS A 1 195 ? -7.938 -35.298 -72.390 1.00 30.00 ? 226 HIS A ND1 1 ATOM 1576 C CD2 . HIS A 1 195 ? -8.928 -36.821 -73.602 1.00 32.58 ? 226 HIS A CD2 1 ATOM 1577 C CE1 . HIS A 1 195 ? -8.920 -35.798 -71.662 1.00 27.58 ? 226 HIS A CE1 1 ATOM 1578 N NE2 . HIS A 1 195 ? -9.535 -36.725 -72.373 1.00 27.67 ? 226 HIS A NE2 1 ATOM 1579 N N . GLY A 1 196 ? -6.358 -32.919 -77.218 1.00 27.53 ? 227 GLY A N 1 ATOM 1580 C CA . GLY A 1 196 ? -5.269 -32.239 -77.890 1.00 28.30 ? 227 GLY A CA 1 ATOM 1581 C C . GLY A 1 196 ? -5.717 -31.445 -79.097 1.00 31.12 ? 227 GLY A C 1 ATOM 1582 O O . GLY A 1 196 ? -6.881 -31.053 -79.205 1.00 30.10 ? 227 GLY A O 1 ATOM 1583 N N . VAL A 1 197 ? -4.782 -31.213 -80.012 1.00 31.06 ? 228 VAL A N 1 ATOM 1584 C CA . VAL A 1 197 ? -5.048 -30.414 -81.199 1.00 29.57 ? 228 VAL A CA 1 ATOM 1585 C C . VAL A 1 197 ? -5.574 -31.284 -82.338 1.00 32.41 ? 228 VAL A C 1 ATOM 1586 O O . VAL A 1 197 ? -4.810 -31.730 -83.195 1.00 27.41 ? 228 VAL A O 1 ATOM 1587 C CB . VAL A 1 197 ? -3.780 -29.665 -81.659 1.00 24.97 ? 228 VAL A CB 1 ATOM 1588 C CG1 . VAL A 1 197 ? -4.119 -28.650 -82.736 1.00 33.62 ? 228 VAL A CG1 1 ATOM 1589 C CG2 . VAL A 1 197 ? -3.126 -28.968 -80.479 1.00 22.84 ? 228 VAL A CG2 1 ATOM 1590 N N . ASP A 1 198 ? -6.883 -31.530 -82.335 1.00 26.59 ? 229 ASP A N 1 ATOM 1591 C CA . ASP A 1 198 ? -7.524 -32.286 -83.405 1.00 26.86 ? 229 ASP A CA 1 ATOM 1592 C C . ASP A 1 198 ? -8.393 -31.383 -84.277 1.00 36.19 ? 229 ASP A C 1 ATOM 1593 O O . ASP A 1 198 ? -9.013 -31.844 -85.239 1.00 31.87 ? 229 ASP A O 1 ATOM 1594 C CB . ASP A 1 198 ? -8.367 -33.433 -82.836 1.00 27.61 ? 229 ASP A CB 1 ATOM 1595 C CG . ASP A 1 198 ? -9.425 -32.962 -81.849 1.00 31.27 ? 229 ASP A CG 1 ATOM 1596 O OD1 . ASP A 1 198 ? -9.677 -31.744 -81.748 1.00 31.51 ? 229 ASP A OD1 1 ATOM 1597 O OD2 . ASP A 1 198 ? -10.020 -33.827 -81.174 1.00 35.30 ? 229 ASP A OD2 1 ATOM 1598 N N . LEU A 1 199 ? -8.436 -30.102 -83.915 1.00 26.93 ? 230 LEU A N 1 ATOM 1599 C CA . LEU A 1 199 ? -9.227 -29.099 -84.622 1.00 28.87 ? 230 LEU A CA 1 ATOM 1600 C C . LEU A 1 199 ? -10.707 -29.463 -84.666 1.00 33.25 ? 230 LEU A C 1 ATOM 1601 O O . LEU A 1 199 ? -11.375 -29.252 -85.677 1.00 36.23 ? 230 LEU A O 1 ATOM 1602 C CB . LEU A 1 199 ? -8.698 -28.894 -86.046 1.00 27.00 ? 230 LEU A CB 1 ATOM 1603 C CG . LEU A 1 199 ? -7.687 -27.765 -86.265 1.00 32.41 ? 230 LEU A CG 1 ATOM 1604 C CD1 . LEU A 1 199 ? -6.497 -27.897 -85.337 1.00 31.65 ? 230 LEU A CD1 1 ATOM 1605 C CD2 . LEU A 1 199 ? -7.231 -27.756 -87.709 1.00 33.40 ? 230 LEU A CD2 1 ATOM 1606 N N . ASN A 1 200 ? -11.219 -30.003 -83.564 1.00 30.23 ? 231 ASN A N 1 ATOM 1607 C CA . ASN A 1 200 ? -12.633 -30.347 -83.485 1.00 27.31 ? 231 ASN A CA 1 ATOM 1608 C C . ASN A 1 200 ? -13.500 -29.097 -83.442 1.00 32.23 ? 231 ASN A C 1 ATOM 1609 O O . ASN A 1 200 ? -14.696 -29.154 -83.720 1.00 36.92 ? 231 ASN A O 1 ATOM 1610 C CB . ASN A 1 200 ? -12.919 -31.228 -82.264 1.00 32.17 ? 231 ASN A CB 1 ATOM 1611 C CG . ASN A 1 200 ? -12.900 -30.450 -80.959 1.00 32.16 ? 231 ASN A CG 1 ATOM 1612 O OD1 . ASN A 1 200 ? -13.893 -29.830 -80.573 1.00 39.08 ? 231 ASN A OD1 1 ATOM 1613 N ND2 . ASN A 1 200 ? -11.769 -30.493 -80.264 1.00 25.01 ? 231 ASN A ND2 1 ATOM 1614 N N . HIS A 1 201 ? -12.892 -27.967 -83.089 1.00 30.21 ? 232 HIS A N 1 ATOM 1615 C CA . HIS A 1 201 ? -13.604 -26.693 -83.050 1.00 31.89 ? 232 HIS A CA 1 ATOM 1616 C C . HIS A 1 201 ? -13.829 -26.143 -84.459 1.00 36.56 ? 232 HIS A C 1 ATOM 1617 O O . HIS A 1 201 ? -14.502 -25.129 -84.641 1.00 39.77 ? 232 HIS A O 1 ATOM 1618 C CB . HIS A 1 201 ? -12.849 -25.669 -82.192 1.00 28.95 ? 232 HIS A CB 1 ATOM 1619 C CG . HIS A 1 201 ? -11.475 -25.340 -82.693 1.00 31.00 ? 232 HIS A CG 1 ATOM 1620 N ND1 . HIS A 1 201 ? -10.732 -26.204 -83.469 1.00 37.05 ? 232 HIS A ND1 1 ATOM 1621 C CD2 . HIS A 1 201 ? -10.709 -24.237 -82.522 1.00 34.50 ? 232 HIS A CD2 1 ATOM 1622 C CE1 . HIS A 1 201 ? -9.567 -25.647 -83.754 1.00 34.76 ? 232 HIS A CE1 1 ATOM 1623 N NE2 . HIS A 1 201 ? -9.529 -24.453 -83.191 1.00 33.82 ? 232 HIS A NE2 1 ATOM 1624 N N . ILE A 1 202 ? -13.263 -26.820 -85.452 1.00 30.88 ? 233 ILE A N 1 ATOM 1625 C CA . ILE A 1 202 ? -13.485 -26.470 -86.846 1.00 26.38 ? 233 ILE A CA 1 ATOM 1626 C C . ILE A 1 202 ? -14.367 -27.516 -87.525 1.00 36.16 ? 233 ILE A C 1 ATOM 1627 O O . ILE A 1 202 ? -15.291 -27.177 -88.269 1.00 32.07 ? 233 ILE A O 1 ATOM 1628 C CB . ILE A 1 202 ? -12.153 -26.349 -87.619 1.00 30.71 ? 233 ILE A CB 1 ATOM 1629 C CG1 . ILE A 1 202 ? -11.272 -25.260 -87.009 1.00 28.13 ? 233 ILE A CG1 1 ATOM 1630 C CG2 . ILE A 1 202 ? -12.405 -26.073 -89.098 1.00 21.72 ? 233 ILE A CG2 1 ATOM 1631 C CD1 . ILE A 1 202 ? -9.920 -25.140 -87.675 1.00 24.34 ? 233 ILE A CD1 1 ATOM 1632 N N . TYR A 1 203 ? -14.084 -28.786 -87.248 1.00 32.72 ? 234 TYR A N 1 ATOM 1633 C CA . TYR A 1 203 ? -14.723 -29.888 -87.959 1.00 30.72 ? 234 TYR A CA 1 ATOM 1634 C C . TYR A 1 203 ? -15.817 -30.585 -87.150 1.00 29.51 ? 234 TYR A C 1 ATOM 1635 O O . TYR A 1 203 ? -16.550 -31.413 -87.683 1.00 28.07 ? 234 TYR A O 1 ATOM 1636 C CB . TYR A 1 203 ? -13.672 -30.917 -88.379 1.00 28.20 ? 234 TYR A CB 1 ATOM 1637 C CG . TYR A 1 203 ? -12.560 -30.356 -89.239 1.00 33.55 ? 234 TYR A CG 1 ATOM 1638 C CD1 . TYR A 1 203 ? -12.761 -30.098 -90.588 1.00 31.49 ? 234 TYR A CD1 1 ATOM 1639 C CD2 . TYR A 1 203 ? -11.305 -30.092 -88.702 1.00 31.62 ? 234 TYR A CD2 1 ATOM 1640 C CE1 . TYR A 1 203 ? -11.748 -29.588 -91.378 1.00 25.55 ? 234 TYR A CE1 1 ATOM 1641 C CE2 . TYR A 1 203 ? -10.285 -29.580 -89.485 1.00 30.59 ? 234 TYR A CE2 1 ATOM 1642 C CZ . TYR A 1 203 ? -10.512 -29.331 -90.823 1.00 29.78 ? 234 TYR A CZ 1 ATOM 1643 O OH . TYR A 1 203 ? -9.501 -28.823 -91.608 1.00 28.97 ? 234 TYR A OH 1 ATOM 1644 N N . GLY A 1 204 ? -15.926 -30.260 -85.867 1.00 28.43 ? 235 GLY A N 1 ATOM 1645 C CA . GLY A 1 204 ? -16.918 -30.893 -85.017 1.00 30.96 ? 235 GLY A CA 1 ATOM 1646 C C . GLY A 1 204 ? -16.353 -32.061 -84.229 1.00 36.34 ? 235 GLY A C 1 ATOM 1647 O O . GLY A 1 204 ? -15.476 -32.782 -84.709 1.00 31.61 ? 235 GLY A O 1 ATOM 1648 N N . GLU A 1 205 ? -16.859 -32.247 -83.013 1.00 40.65 ? 236 GLU A N 1 ATOM 1649 C CA . GLU A 1 205 ? -16.399 -33.326 -82.144 1.00 38.20 ? 236 GLU A CA 1 ATOM 1650 C C . GLU A 1 205 ? -16.808 -34.701 -82.673 1.00 36.07 ? 236 GLU A C 1 ATOM 1651 O O . GLU A 1 205 ? -16.018 -35.644 -82.646 1.00 44.13 ? 236 GLU A O 1 ATOM 1652 C CB . GLU A 1 205 ? -16.939 -33.131 -80.724 1.00 37.12 ? 236 GLU A CB 1 ATOM 1653 C CG . GLU A 1 205 ? -16.547 -34.228 -79.745 1.00 43.02 ? 236 GLU A CG 1 ATOM 1654 C CD . GLU A 1 205 ? -15.055 -34.260 -79.458 1.00 45.93 ? 236 GLU A CD 1 ATOM 1655 O OE1 . GLU A 1 205 ? -14.493 -35.370 -79.340 1.00 44.56 ? 236 GLU A OE1 1 ATOM 1656 O OE2 . GLU A 1 205 ? -14.446 -33.177 -79.343 1.00 37.37 ? 236 GLU A OE2 1 ATOM 1657 N N . THR A 1 206 ? -18.043 -34.808 -83.153 1.00 40.40 ? 237 THR A N 1 ATOM 1658 C CA . THR A 1 206 ? -18.568 -36.080 -83.637 1.00 36.00 ? 237 THR A CA 1 ATOM 1659 C C . THR A 1 206 ? -18.634 -36.129 -85.160 1.00 33.57 ? 237 THR A C 1 ATOM 1660 O O . THR A 1 206 ? -18.603 -35.095 -85.828 1.00 35.79 ? 237 THR A O 1 ATOM 1661 C CB . THR A 1 206 ? -19.971 -36.362 -83.066 1.00 34.19 ? 237 THR A CB 1 ATOM 1662 O OG1 . THR A 1 206 ? -20.894 -35.374 -83.539 1.00 39.04 ? 237 THR A OG1 1 ATOM 1663 C CG2 . THR A 1 206 ? -19.938 -36.332 -81.549 1.00 29.30 ? 237 THR A CG2 1 ATOM 1664 N N . LEU A 1 207 ? -18.733 -37.340 -85.697 1.00 34.68 ? 238 LEU A N 1 ATOM 1665 C CA . LEU A 1 207 ? -18.780 -37.555 -87.138 1.00 27.66 ? 238 LEU A CA 1 ATOM 1666 C C . LEU A 1 207 ? -20.068 -37.002 -87.743 1.00 37.41 ? 238 LEU A C 1 ATOM 1667 O O . LEU A 1 207 ? -20.077 -36.523 -88.877 1.00 35.30 ? 238 LEU A O 1 ATOM 1668 C CB . LEU A 1 207 ? -18.648 -39.046 -87.454 1.00 24.98 ? 238 LEU A CB 1 ATOM 1669 C CG . LEU A 1 207 ? -18.496 -39.419 -88.928 1.00 34.27 ? 238 LEU A CG 1 ATOM 1670 C CD1 . LEU A 1 207 ? -17.201 -38.853 -89.488 1.00 38.49 ? 238 LEU A CD1 1 ATOM 1671 C CD2 . LEU A 1 207 ? -18.553 -40.925 -89.114 1.00 33.32 ? 238 LEU A CD2 1 ATOM 1672 N N . ASP A 1 208 ? -21.153 -37.072 -86.976 1.00 42.35 ? 239 ASP A N 1 ATOM 1673 C CA . ASP A 1 208 ? -22.449 -36.569 -87.417 1.00 44.13 ? 239 ASP A CA 1 ATOM 1674 C C . ASP A 1 208 ? -22.389 -35.070 -87.676 1.00 47.55 ? 239 ASP A C 1 ATOM 1675 O O . ASP A 1 208 ? -22.894 -34.580 -88.687 1.00 46.68 ? 239 ASP A O 1 ATOM 1676 C CB . ASP A 1 208 ? -23.528 -36.876 -86.377 1.00 52.99 ? 239 ASP A CB 1 ATOM 1677 C CG . ASP A 1 208 ? -23.622 -38.353 -86.054 1.00 102.43 ? 239 ASP A CG 1 ATOM 1678 O OD1 . ASP A 1 208 ? -22.748 -38.860 -85.317 1.00 81.49 ? 239 ASP A OD1 1 ATOM 1679 O OD2 . ASP A 1 208 ? -24.574 -39.007 -86.531 1.00 99.45 ? 239 ASP A OD2 1 ATOM 1680 N N . ARG A 1 209 ? -21.763 -34.348 -86.753 1.00 37.65 ? 240 ARG A N 1 ATOM 1681 C CA . ARG A 1 209 ? -21.638 -32.904 -86.865 1.00 32.63 ? 240 ARG A CA 1 ATOM 1682 C C . ARG A 1 209 ? -20.674 -32.538 -87.986 1.00 37.18 ? 240 ARG A C 1 ATOM 1683 O O . ARG A 1 209 ? -20.848 -31.523 -88.660 1.00 37.75 ? 240 ARG A O 1 ATOM 1684 C CB . ARG A 1 209 ? -21.169 -32.302 -85.539 1.00 29.62 ? 240 ARG A CB 1 ATOM 1685 C CG . ARG A 1 209 ? -21.220 -30.785 -85.499 1.00 28.11 ? 240 ARG A CG 1 ATOM 1686 C CD . ARG A 1 209 ? -20.772 -30.259 -84.150 1.00 32.35 ? 240 ARG A CD 1 ATOM 1687 N NE . ARG A 1 209 ? -20.863 -28.805 -84.074 1.00 36.50 ? 240 ARG A NE 1 ATOM 1688 C CZ . ARG A 1 209 ? -21.945 -28.146 -83.673 1.00 47.41 ? 240 ARG A CZ 1 ATOM 1689 N NH1 . ARG A 1 209 ? -23.032 -28.813 -83.310 1.00 50.22 ? 240 ARG A NH1 1 ATOM 1690 N NH2 . ARG A 1 209 ? -21.940 -26.821 -83.635 1.00 54.23 ? 240 ARG A NH2 1 ATOM 1691 N N . GLN A 1 210 ? -19.659 -33.374 -88.182 1.00 33.47 ? 241 GLN A N 1 ATOM 1692 C CA . GLN A 1 210 ? -18.685 -33.155 -89.242 1.00 33.26 ? 241 GLN A CA 1 ATOM 1693 C C . GLN A 1 210 ? -19.342 -33.233 -90.614 1.00 35.50 ? 241 GLN A C 1 ATOM 1694 O O . GLN A 1 210 ? -19.058 -32.423 -91.495 1.00 41.58 ? 241 GLN A O 1 ATOM 1695 C CB . GLN A 1 210 ? -17.546 -34.174 -89.153 1.00 30.69 ? 241 GLN A CB 1 ATOM 1696 C CG . GLN A 1 210 ? -16.446 -33.952 -90.181 1.00 26.92 ? 241 GLN A CG 1 ATOM 1697 C CD . GLN A 1 210 ? -15.621 -35.199 -90.439 1.00 36.52 ? 241 GLN A CD 1 ATOM 1698 O OE1 . GLN A 1 210 ? -15.697 -35.794 -91.514 1.00 35.81 ? 241 GLN A OE1 1 ATOM 1699 N NE2 . GLN A 1 210 ? -14.825 -35.598 -89.453 1.00 38.07 ? 241 GLN A NE2 1 ATOM 1700 N N . HIS A 1 211 ? -20.226 -34.210 -90.786 1.00 35.13 ? 242 HIS A N 1 ATOM 1701 C CA . HIS A 1 211 ? -20.877 -34.430 -92.070 1.00 38.17 ? 242 HIS A CA 1 ATOM 1702 C C . HIS A 1 211 ? -21.914 -33.356 -92.376 1.00 42.32 ? 242 HIS A C 1 ATOM 1703 O O . HIS A 1 211 ? -22.171 -33.050 -93.540 1.00 43.52 ? 242 HIS A O 1 ATOM 1704 C CB . HIS A 1 211 ? -21.520 -35.817 -92.106 1.00 33.78 ? 242 HIS A CB 1 ATOM 1705 C CG . HIS A 1 211 ? -20.534 -36.929 -92.289 1.00 40.84 ? 242 HIS A CG 1 ATOM 1706 N ND1 . HIS A 1 211 ? -20.906 -38.254 -92.354 1.00 41.50 ? 242 HIS A ND1 1 ATOM 1707 C CD2 . HIS A 1 211 ? -19.187 -36.909 -92.426 1.00 40.10 ? 242 HIS A CD2 1 ATOM 1708 C CE1 . HIS A 1 211 ? -19.830 -39.004 -92.522 1.00 40.69 ? 242 HIS A CE1 1 ATOM 1709 N NE2 . HIS A 1 211 ? -18.774 -38.212 -92.568 1.00 36.21 ? 242 HIS A NE2 1 ATOM 1710 N N . LYS A 1 212 ? -22.507 -32.780 -91.335 1.00 37.16 ? 243 LYS A N 1 ATOM 1711 C CA . LYS A 1 212 ? -23.447 -31.681 -91.526 1.00 36.62 ? 243 LYS A CA 1 ATOM 1712 C C . LYS A 1 212 ? -22.713 -30.421 -91.976 1.00 41.30 ? 243 LYS A C 1 ATOM 1713 O O . LYS A 1 212 ? -23.281 -29.580 -92.671 1.00 49.11 ? 243 LYS A O 1 ATOM 1714 C CB . LYS A 1 212 ? -24.235 -31.399 -90.243 1.00 40.10 ? 243 LYS A CB 1 ATOM 1715 C CG . LYS A 1 212 ? -25.085 -32.557 -89.744 1.00 31.76 ? 243 LYS A CG 1 ATOM 1716 C CD . LYS A 1 212 ? -26.449 -32.075 -89.277 1.00 40.61 ? 243 LYS A CD 1 ATOM 1717 C CE . LYS A 1 212 ? -27.045 -32.978 -88.214 1.00 44.82 ? 243 LYS A CE 1 ATOM 1718 N NZ . LYS A 1 212 ? -26.544 -32.636 -86.854 1.00 52.29 ? 243 LYS A NZ 1 ATOM 1719 N N . LEU A 1 213 ? -21.449 -30.302 -91.579 1.00 39.57 ? 244 LEU A N 1 ATOM 1720 C CA . LEU A 1 213 ? -20.643 -29.126 -91.897 1.00 35.48 ? 244 LEU A CA 1 ATOM 1721 C C . LEU A 1 213 ? -19.939 -29.235 -93.251 1.00 40.12 ? 244 LEU A C 1 ATOM 1722 O O . LEU A 1 213 ? -19.509 -28.226 -93.813 1.00 39.84 ? 244 LEU A O 1 ATOM 1723 C CB . LEU A 1 213 ? -19.601 -28.885 -90.802 1.00 29.12 ? 244 LEU A CB 1 ATOM 1724 C CG . LEU A 1 213 ? -20.104 -28.383 -89.448 1.00 32.01 ? 244 LEU A CG 1 ATOM 1725 C CD1 . LEU A 1 213 ? -18.957 -28.282 -88.454 1.00 23.34 ? 244 LEU A CD1 1 ATOM 1726 C CD2 . LEU A 1 213 ? -20.800 -27.041 -89.601 1.00 29.82 ? 244 LEU A CD2 1 ATOM 1727 N N . ARG A 1 214 ? -19.820 -30.454 -93.769 1.00 38.06 ? 245 ARG A N 1 ATOM 1728 C CA . ARG A 1 214 ? -19.093 -30.688 -95.016 1.00 38.67 ? 245 ARG A CA 1 ATOM 1729 C C . ARG A 1 214 ? -19.969 -30.493 -96.253 1.00 40.92 ? 245 ARG A C 1 ATOM 1730 O O . ARG A 1 214 ? -21.189 -30.638 -96.200 1.00 44.24 ? 245 ARG A O 1 ATOM 1731 C CB . ARG A 1 214 ? -18.487 -32.095 -95.024 1.00 31.94 ? 245 ARG A CB 1 ATOM 1732 C CG . ARG A 1 214 ? -17.215 -32.232 -94.194 1.00 33.36 ? 245 ARG A CG 1 ATOM 1733 C CD . ARG A 1 214 ? -16.763 -33.684 -94.081 1.00 32.50 ? 245 ARG A CD 1 ATOM 1734 N NE . ARG A 1 214 ? -16.387 -34.256 -95.371 1.00 31.46 ? 245 ARG A NE 1 ATOM 1735 C CZ . ARG A 1 214 ? -15.925 -35.492 -95.531 1.00 34.10 ? 245 ARG A CZ 1 ATOM 1736 N NH1 . ARG A 1 214 ? -15.781 -36.289 -94.480 1.00 39.16 ? 245 ARG A NH1 1 ATOM 1737 N NH2 . ARG A 1 214 ? -15.605 -35.935 -96.740 1.00 32.34 ? 245 ARG A NH2 1 ATOM 1738 N N . LEU A 1 215 ? -19.324 -30.160 -97.367 1.00 41.36 ? 246 LEU A N 1 ATOM 1739 C CA . LEU A 1 215 ? -20.006 -29.949 -98.638 1.00 38.37 ? 246 LEU A CA 1 ATOM 1740 C C . LEU A 1 215 ? -20.017 -31.231 -99.470 1.00 36.93 ? 246 LEU A C 1 ATOM 1741 O O . LEU A 1 215 ? -20.839 -31.395 -100.371 1.00 38.80 ? 246 LEU A O 1 ATOM 1742 C CB . LEU A 1 215 ? -19.328 -28.814 -99.413 1.00 39.87 ? 246 LEU A CB 1 ATOM 1743 C CG . LEU A 1 215 ? -19.902 -28.384 -100.765 1.00 35.53 ? 246 LEU A CG 1 ATOM 1744 C CD1 . LEU A 1 215 ? -21.273 -27.752 -100.590 1.00 24.20 ? 246 LEU A CD1 1 ATOM 1745 C CD2 . LEU A 1 215 ? -18.945 -27.427 -101.462 1.00 34.95 ? 246 LEU A CD2 1 ATOM 1746 N N . PHE A 1 216 ? -19.094 -32.133 -99.145 1.00 36.04 ? 247 PHE A N 1 ATOM 1747 C CA . PHE A 1 216 ? -18.919 -33.403 -99.852 1.00 38.15 ? 247 PHE A CA 1 ATOM 1748 C C . PHE A 1 216 ? -18.609 -33.186 -101.328 1.00 40.66 ? 247 PHE A C 1 ATOM 1749 O O . PHE A 1 216 ? -18.958 -33.999 -102.184 1.00 35.60 ? 247 PHE A O 1 ATOM 1750 C CB . PHE A 1 216 ? -20.147 -34.296 -99.674 1.00 26.91 ? 247 PHE A CB 1 ATOM 1751 C CG . PHE A 1 216 ? -20.318 -34.797 -98.269 1.00 34.58 ? 247 PHE A CG 1 ATOM 1752 C CD1 . PHE A 1 216 ? -19.559 -35.857 -97.802 1.00 28.00 ? 247 PHE A CD1 1 ATOM 1753 C CD2 . PHE A 1 216 ? -21.218 -34.193 -97.407 1.00 35.49 ? 247 PHE A CD2 1 ATOM 1754 C CE1 . PHE A 1 216 ? -19.702 -36.314 -96.508 1.00 31.62 ? 247 PHE A CE1 1 ATOM 1755 C CE2 . PHE A 1 216 ? -21.367 -34.646 -96.112 1.00 31.26 ? 247 PHE A CE2 1 ATOM 1756 C CZ . PHE A 1 216 ? -20.608 -35.707 -95.660 1.00 28.74 ? 247 PHE A CZ 1 ATOM 1757 N N . LYS A 1 217 ? -17.935 -32.074 -101.603 1.00 45.31 ? 248 LYS A N 1 ATOM 1758 C CA . LYS A 1 217 ? -17.365 -31.800 -102.914 1.00 44.43 ? 248 LYS A CA 1 ATOM 1759 C C . LYS A 1 217 ? -15.988 -31.159 -102.731 1.00 44.75 ? 248 LYS A C 1 ATOM 1760 O O . LYS A 1 217 ? -15.845 -30.185 -101.987 1.00 46.41 ? 248 LYS A O 1 ATOM 1761 C CB . LYS A 1 217 ? -18.283 -30.891 -103.733 1.00 40.35 ? 248 LYS A CB 1 ATOM 1762 C CG . LYS A 1 217 ? -17.692 -30.464 -105.067 1.00 45.03 ? 248 LYS A CG 1 ATOM 1763 C CD . LYS A 1 217 ? -18.479 -29.315 -105.679 1.00 70.71 ? 248 LYS A CD 1 ATOM 1764 C CE . LYS A 1 217 ? -17.750 -28.721 -106.875 1.00 63.46 ? 248 LYS A CE 1 ATOM 1765 N NZ . LYS A 1 217 ? -18.410 -27.473 -107.351 1.00 51.07 ? 248 LYS A NZ 1 ATOM 1766 N N . ASP A 1 218 ? -14.981 -31.726 -103.391 1.00 35.02 ? 249 ASP A N 1 ATOM 1767 C CA . ASP A 1 218 ? -13.603 -31.239 -103.309 1.00 39.54 ? 249 ASP A CA 1 ATOM 1768 C C . ASP A 1 218 ? -13.050 -31.228 -101.881 1.00 43.16 ? 249 ASP A C 1 ATOM 1769 O O . ASP A 1 218 ? -12.078 -30.528 -101.594 1.00 37.92 ? 249 ASP A O 1 ATOM 1770 C CB . ASP A 1 218 ? -13.495 -29.833 -103.909 1.00 55.43 ? 249 ASP A CB 1 ATOM 1771 C CG . ASP A 1 218 ? -13.965 -29.773 -105.346 1.00 54.13 ? 249 ASP A CG 1 ATOM 1772 O OD1 . ASP A 1 218 ? -14.002 -30.833 -106.004 1.00 47.64 ? 249 ASP A OD1 1 ATOM 1773 O OD2 . ASP A 1 218 ? -14.295 -28.664 -105.819 1.00 57.41 ? 249 ASP A OD2 1 ATOM 1774 N N . GLY A 1 219 ? -13.664 -32.004 -100.992 1.00 42.62 ? 250 GLY A N 1 ATOM 1775 C CA . GLY A 1 219 ? -13.213 -32.095 -99.613 1.00 31.83 ? 250 GLY A CA 1 ATOM 1776 C C . GLY A 1 219 ? -13.475 -30.840 -98.806 1.00 37.97 ? 250 GLY A C 1 ATOM 1777 O O . GLY A 1 219 ? -12.923 -30.665 -97.721 1.00 37.69 ? 250 GLY A O 1 ATOM 1778 N N . LYS A 1 220 ? -14.330 -29.969 -99.330 1.00 32.96 ? 251 LYS A N 1 ATOM 1779 C CA . LYS A 1 220 ? -14.545 -28.659 -98.728 1.00 32.32 ? 251 LYS A CA 1 ATOM 1780 C C . LYS A 1 220 ? -15.624 -28.662 -97.649 1.00 33.03 ? 251 LYS A C 1 ATOM 1781 O O . LYS A 1 220 ? -16.468 -29.555 -97.596 1.00 36.66 ? 251 LYS A O 1 ATOM 1782 C CB . LYS A 1 220 ? -14.905 -27.640 -99.813 1.00 37.67 ? 251 LYS A CB 1 ATOM 1783 C CG . LYS A 1 220 ? -13.808 -27.433 -100.845 1.00 44.10 ? 251 LYS A CG 1 ATOM 1784 C CD . LYS A 1 220 ? -14.199 -26.392 -101.879 1.00 41.00 ? 251 LYS A CD 1 ATOM 1785 C CE . LYS A 1 220 ? -13.108 -26.236 -102.927 1.00 43.69 ? 251 LYS A CE 1 ATOM 1786 N NZ . LYS A 1 220 ? -13.461 -25.222 -103.957 1.00 39.76 ? 251 LYS A NZ 1 ATOM 1787 N N . LEU A 1 221 ? -15.575 -27.654 -96.784 1.00 31.80 ? 252 LEU A N 1 ATOM 1788 C CA . LEU A 1 221 ? -16.635 -27.413 -95.816 1.00 36.37 ? 252 LEU A CA 1 ATOM 1789 C C . LEU A 1 221 ? -17.675 -26.490 -96.439 1.00 32.27 ? 252 LEU A C 1 ATOM 1790 O O . LEU A 1 221 ? -17.359 -25.720 -97.345 1.00 31.80 ? 252 LEU A O 1 ATOM 1791 C CB . LEU A 1 221 ? -16.076 -26.795 -94.533 1.00 36.80 ? 252 LEU A CB 1 ATOM 1792 C CG . LEU A 1 221 ? -15.109 -27.614 -93.678 1.00 30.44 ? 252 LEU A CG 1 ATOM 1793 C CD1 . LEU A 1 221 ? -14.435 -26.722 -92.645 1.00 24.80 ? 252 LEU A CD1 1 ATOM 1794 C CD2 . LEU A 1 221 ? -15.840 -28.764 -93.003 1.00 24.59 ? 252 LEU A CD2 1 ATOM 1795 N N . LYS A 1 222 ? -18.913 -26.569 -95.959 1.00 36.61 ? 253 LYS A N 1 ATOM 1796 C CA . LYS A 1 222 ? -19.977 -25.706 -96.463 1.00 37.70 ? 253 LYS A CA 1 ATOM 1797 C C . LYS A 1 222 ? -19.663 -24.242 -96.183 1.00 39.43 ? 253 LYS A C 1 ATOM 1798 O O . LYS A 1 222 ? -18.991 -23.918 -95.205 1.00 35.39 ? 253 LYS A O 1 ATOM 1799 C CB . LYS A 1 222 ? -21.324 -26.083 -95.846 1.00 35.44 ? 253 LYS A CB 1 ATOM 1800 C CG . LYS A 1 222 ? -21.972 -27.311 -96.462 1.00 39.50 ? 253 LYS A CG 1 ATOM 1801 C CD . LYS A 1 222 ? -23.274 -27.652 -95.757 1.00 42.22 ? 253 LYS A CD 1 ATOM 1802 C CE . LYS A 1 222 ? -24.009 -28.781 -96.460 1.00 49.52 ? 253 LYS A CE 1 ATOM 1803 N NZ . LYS A 1 222 ? -25.178 -29.242 -95.659 1.00 57.24 ? 253 LYS A NZ 1 ATOM 1804 N N . TYR A 1 223 ? -20.153 -23.364 -97.049 1.00 38.94 ? 254 TYR A N 1 ATOM 1805 C CA . TYR A 1 223 ? -19.884 -21.939 -96.922 1.00 35.75 ? 254 TYR A CA 1 ATOM 1806 C C . TYR A 1 223 ? -20.979 -21.106 -97.577 1.00 35.58 ? 254 TYR A C 1 ATOM 1807 O O . TYR A 1 223 ? -21.812 -21.624 -98.321 1.00 36.01 ? 254 TYR A O 1 ATOM 1808 C CB . TYR A 1 223 ? -18.528 -21.595 -97.547 1.00 32.74 ? 254 TYR A CB 1 ATOM 1809 C CG . TYR A 1 223 ? -18.447 -21.917 -99.023 1.00 30.95 ? 254 TYR A CG 1 ATOM 1810 C CD1 . TYR A 1 223 ? -17.993 -23.155 -99.460 1.00 30.58 ? 254 TYR A CD1 1 ATOM 1811 C CD2 . TYR A 1 223 ? -18.836 -20.989 -99.980 1.00 33.86 ? 254 TYR A CD2 1 ATOM 1812 C CE1 . TYR A 1 223 ? -17.924 -23.457 -100.808 1.00 27.83 ? 254 TYR A CE1 1 ATOM 1813 C CE2 . TYR A 1 223 ? -18.775 -21.283 -101.328 1.00 31.86 ? 254 TYR A CE2 1 ATOM 1814 C CZ . TYR A 1 223 ? -18.316 -22.515 -101.737 1.00 32.43 ? 254 TYR A CZ 1 ATOM 1815 O OH . TYR A 1 223 ? -18.251 -22.809 -103.078 1.00 32.89 ? 254 TYR A OH 1 ATOM 1816 N N . GLN A 1 224 ? -20.965 -19.811 -97.292 1.00 37.46 ? 255 GLN A N 1 ATOM 1817 C CA . GLN A 1 224 ? -21.818 -18.857 -97.983 1.00 31.85 ? 255 GLN A CA 1 ATOM 1818 C C . GLN A 1 224 ? -21.011 -17.597 -98.265 1.00 42.45 ? 255 GLN A C 1 ATOM 1819 O O . GLN A 1 224 ? -20.028 -17.316 -97.578 1.00 42.74 ? 255 GLN A O 1 ATOM 1820 C CB . GLN A 1 224 ? -23.063 -18.527 -97.160 1.00 26.40 ? 255 GLN A CB 1 ATOM 1821 C CG . GLN A 1 224 ? -22.768 -17.921 -95.799 1.00 34.70 ? 255 GLN A CG 1 ATOM 1822 C CD . GLN A 1 224 ? -24.022 -17.464 -95.082 1.00 37.91 ? 255 GLN A CD 1 ATOM 1823 O OE1 . GLN A 1 224 ? -25.038 -17.171 -95.711 1.00 43.30 ? 255 GLN A OE1 1 ATOM 1824 N NE2 . GLN A 1 224 ? -23.958 -17.404 -93.758 1.00 41.60 ? 255 GLN A NE2 1 ATOM 1825 N N . VAL A 1 225 ? -21.413 -16.844 -99.282 1.00 37.96 ? 256 VAL A N 1 ATOM 1826 C CA . VAL A 1 225 ? -20.707 -15.614 -99.615 1.00 33.29 ? 256 VAL A CA 1 ATOM 1827 C C . VAL A 1 225 ? -21.593 -14.399 -99.374 1.00 36.38 ? 256 VAL A C 1 ATOM 1828 O O . VAL A 1 225 ? -22.680 -14.285 -99.939 1.00 47.73 ? 256 VAL A O 1 ATOM 1829 C CB . VAL A 1 225 ? -20.220 -15.613 -101.074 1.00 32.74 ? 256 VAL A CB 1 ATOM 1830 C CG1 . VAL A 1 225 ? -19.662 -14.251 -101.447 1.00 30.34 ? 256 VAL A CG1 1 ATOM 1831 C CG2 . VAL A 1 225 ? -19.168 -16.691 -101.276 1.00 34.42 ? 256 VAL A CG2 1 ATOM 1832 N N . ILE A 1 226 ? -21.117 -13.499 -98.519 1.00 38.59 ? 257 ILE A N 1 ATOM 1833 C CA . ILE A 1 226 ? -21.830 -12.267 -98.206 1.00 36.37 ? 257 ILE A CA 1 ATOM 1834 C C . ILE A 1 226 ? -20.945 -11.054 -98.474 1.00 36.23 ? 257 ILE A C 1 ATOM 1835 O O . ILE A 1 226 ? -19.928 -10.860 -97.812 1.00 41.85 ? 257 ILE A O 1 ATOM 1836 C CB . ILE A 1 226 ? -22.297 -12.241 -96.739 1.00 36.12 ? 257 ILE A CB 1 ATOM 1837 C CG1 . ILE A 1 226 ? -23.172 -13.459 -96.430 1.00 31.00 ? 257 ILE A CG1 1 ATOM 1838 C CG2 . ILE A 1 226 ? -23.045 -10.952 -96.441 1.00 34.00 ? 257 ILE A CG2 1 ATOM 1839 C CD1 . ILE A 1 226 ? -23.551 -13.576 -94.973 1.00 32.41 ? 257 ILE A CD1 1 ATOM 1840 N N . GLY A 1 227 ? -21.335 -10.244 -99.451 1.00 37.21 ? 258 GLY A N 1 ATOM 1841 C CA . GLY A 1 227 ? -20.571 -9.064 -99.805 1.00 23.32 ? 258 GLY A CA 1 ATOM 1842 C C . GLY A 1 227 ? -19.259 -9.408 -100.484 1.00 36.21 ? 258 GLY A C 1 ATOM 1843 O O . GLY A 1 227 ? -18.286 -8.660 -100.390 1.00 45.78 ? 258 GLY A O 1 ATOM 1844 N N . GLY A 1 228 ? -19.232 -10.550 -101.165 1.00 33.85 ? 259 GLY A N 1 ATOM 1845 C CA . GLY A 1 228 ? -18.052 -10.974 -101.897 1.00 28.90 ? 259 GLY A CA 1 ATOM 1846 C C . GLY A 1 228 ? -17.087 -11.803 -101.071 1.00 37.40 ? 259 GLY A C 1 ATOM 1847 O O . GLY A 1 228 ? -16.131 -12.367 -101.602 1.00 39.78 ? 259 GLY A O 1 ATOM 1848 N N . GLU A 1 229 ? -17.340 -11.884 -99.770 1.00 36.12 ? 260 GLU A N 1 ATOM 1849 C CA . GLU A 1 229 ? -16.449 -12.598 -98.865 1.00 33.05 ? 260 GLU A CA 1 ATOM 1850 C C . GLU A 1 229 ? -17.118 -13.842 -98.278 1.00 37.98 ? 260 GLU A C 1 ATOM 1851 O O . GLU A 1 229 ? -18.341 -13.902 -98.150 1.00 38.74 ? 260 GLU A O 1 ATOM 1852 C CB . GLU A 1 229 ? -15.975 -11.660 -97.755 1.00 35.22 ? 260 GLU A CB 1 ATOM 1853 C CG . GLU A 1 229 ? -15.159 -10.483 -98.279 1.00 40.92 ? 260 GLU A CG 1 ATOM 1854 C CD . GLU A 1 229 ? -14.961 -9.392 -97.246 1.00 77.44 ? 260 GLU A CD 1 ATOM 1855 O OE1 . GLU A 1 229 ? -15.653 -8.355 -97.339 1.00 61.46 ? 260 GLU A OE1 1 ATOM 1856 O OE2 . GLU A 1 229 ? -14.113 -9.568 -96.344 1.00 75.81 ? 260 GLU A OE2 1 ATOM 1857 N N . VAL A 1 230 ? -16.304 -14.832 -97.924 1.00 38.39 ? 261 VAL A N 1 ATOM 1858 C CA . VAL A 1 230 ? -16.805 -16.133 -97.480 1.00 35.35 ? 261 VAL A CA 1 ATOM 1859 C C . VAL A 1 230 ? -17.051 -16.189 -95.970 1.00 33.15 ? 261 VAL A C 1 ATOM 1860 O O . VAL A 1 230 ? -16.236 -15.720 -95.177 1.00 36.25 ? 261 VAL A O 1 ATOM 1861 C CB . VAL A 1 230 ? -15.826 -17.256 -97.876 1.00 26.33 ? 261 VAL A CB 1 ATOM 1862 C CG1 . VAL A 1 230 ? -16.226 -18.579 -97.247 1.00 31.21 ? 261 VAL A CG1 1 ATOM 1863 C CG2 . VAL A 1 230 ? -15.759 -17.382 -99.393 1.00 29.40 ? 261 VAL A CG2 1 ATOM 1864 N N . TYR A 1 231 ? -18.187 -16.764 -95.585 1.00 37.88 ? 262 TYR A N 1 ATOM 1865 C CA . TYR A 1 231 ? -18.549 -16.925 -94.180 1.00 38.19 ? 262 TYR A CA 1 ATOM 1866 C C . TYR A 1 231 ? -19.096 -18.332 -93.941 1.00 37.98 ? 262 TYR A C 1 ATOM 1867 O O . TYR A 1 231 ? -19.490 -19.010 -94.891 1.00 37.77 ? 262 TYR A O 1 ATOM 1868 C CB . TYR A 1 231 ? -19.578 -15.866 -93.770 1.00 33.36 ? 262 TYR A CB 1 ATOM 1869 C CG . TYR A 1 231 ? -19.035 -14.456 -93.784 1.00 36.15 ? 262 TYR A CG 1 ATOM 1870 C CD1 . TYR A 1 231 ? -18.437 -13.909 -92.655 1.00 33.33 ? 262 TYR A CD1 1 ATOM 1871 C CD2 . TYR A 1 231 ? -19.114 -13.674 -94.929 1.00 39.10 ? 262 TYR A CD2 1 ATOM 1872 C CE1 . TYR A 1 231 ? -17.936 -12.621 -92.664 1.00 31.76 ? 262 TYR A CE1 1 ATOM 1873 C CE2 . TYR A 1 231 ? -18.614 -12.383 -94.948 1.00 39.48 ? 262 TYR A CE2 1 ATOM 1874 C CZ . TYR A 1 231 ? -18.027 -11.863 -93.813 1.00 31.94 ? 262 TYR A CZ 1 ATOM 1875 O OH . TYR A 1 231 ? -17.531 -10.582 -93.827 1.00 42.27 ? 262 TYR A OH 1 ATOM 1876 N N . PRO A 1 232 ? -19.102 -18.786 -92.674 1.00 39.47 ? 263 PRO A N 1 ATOM 1877 C CA . PRO A 1 232 ? -19.672 -20.097 -92.340 1.00 34.22 ? 263 PRO A CA 1 ATOM 1878 C C . PRO A 1 232 ? -21.138 -20.223 -92.747 1.00 40.01 ? 263 PRO A C 1 ATOM 1879 O O . PRO A 1 232 ? -21.837 -19.213 -92.830 1.00 39.41 ? 263 PRO A O 1 ATOM 1880 C CB . PRO A 1 232 ? -19.521 -20.163 -90.818 1.00 39.66 ? 263 PRO A CB 1 ATOM 1881 C CG . PRO A 1 232 ? -18.357 -19.294 -90.525 1.00 41.13 ? 263 PRO A CG 1 ATOM 1882 C CD . PRO A 1 232 ? -18.438 -18.168 -91.512 1.00 40.86 ? 263 PRO A CD 1 ATOM 1883 N N . PRO A 1 233 ? -21.599 -21.457 -93.000 1.00 40.95 ? 264 PRO A N 1 ATOM 1884 C CA . PRO A 1 233 ? -23.000 -21.682 -93.364 1.00 36.43 ? 264 PRO A CA 1 ATOM 1885 C C . PRO A 1 233 ? -23.934 -21.412 -92.192 1.00 39.16 ? 264 PRO A C 1 ATOM 1886 O O . PRO A 1 233 ? -23.478 -21.231 -91.061 1.00 36.47 ? 264 PRO A O 1 ATOM 1887 C CB . PRO A 1 233 ? -23.026 -23.158 -93.757 1.00 36.71 ? 264 PRO A CB 1 ATOM 1888 C CG . PRO A 1 233 ? -21.913 -23.766 -92.986 1.00 36.63 ? 264 PRO A CG 1 ATOM 1889 C CD . PRO A 1 233 ? -20.839 -22.716 -92.921 1.00 40.47 ? 264 PRO A CD 1 ATOM 1890 N N . THR A 1 234 ? -25.233 -21.390 -92.463 1.00 42.80 ? 265 THR A N 1 ATOM 1891 C CA . THR A 1 234 ? -26.220 -21.112 -91.429 1.00 49.97 ? 265 THR A CA 1 ATOM 1892 C C . THR A 1 234 ? -26.666 -22.382 -90.708 1.00 47.51 ? 265 THR A C 1 ATOM 1893 O O . THR A 1 234 ? -26.436 -23.495 -91.184 1.00 45.34 ? 265 THR A O 1 ATOM 1894 C CB . THR A 1 234 ? -27.455 -20.407 -92.017 1.00 46.42 ? 265 THR A CB 1 ATOM 1895 O OG1 . THR A 1 234 ? -27.930 -21.143 -93.152 1.00 55.10 ? 265 THR A OG1 1 ATOM 1896 C CG2 . THR A 1 234 ? -27.100 -18.993 -92.451 1.00 51.65 ? 265 THR A CG2 1 ATOM 1897 N N . VAL A 1 235 ? -27.299 -22.204 -89.553 1.00 43.82 ? 266 VAL A N 1 ATOM 1898 C CA . VAL A 1 235 ? -27.893 -23.315 -88.821 1.00 46.62 ? 266 VAL A CA 1 ATOM 1899 C C . VAL A 1 235 ? -28.999 -23.955 -89.658 1.00 45.79 ? 266 VAL A C 1 ATOM 1900 O O . VAL A 1 235 ? -29.171 -25.173 -89.656 1.00 48.72 ? 266 VAL A O 1 ATOM 1901 C CB . VAL A 1 235 ? -28.453 -22.850 -87.456 1.00 36.56 ? 266 VAL A CB 1 ATOM 1902 C CG1 . VAL A 1 235 ? -29.322 -23.925 -86.828 1.00 30.28 ? 266 VAL A CG1 1 ATOM 1903 C CG2 . VAL A 1 235 ? -27.315 -22.469 -86.521 1.00 42.39 ? 266 VAL A CG2 1 ATOM 1904 N N . LYS A 1 236 ? -29.729 -23.122 -90.392 1.00 46.73 ? 267 LYS A N 1 ATOM 1905 C CA . LYS A 1 236 ? -30.823 -23.584 -91.237 1.00 53.86 ? 267 LYS A CA 1 ATOM 1906 C C . LYS A 1 236 ? -30.359 -24.538 -92.338 1.00 54.43 ? 267 LYS A C 1 ATOM 1907 O O . LYS A 1 236 ? -30.999 -25.558 -92.596 1.00 55.41 ? 267 LYS A O 1 ATOM 1908 C CB . LYS A 1 236 ? -31.541 -22.385 -91.860 1.00 65.82 ? 267 LYS A CB 1 ATOM 1909 C CG . LYS A 1 236 ? -32.383 -22.727 -93.077 1.00 70.06 ? 267 LYS A CG 1 ATOM 1910 C CD . LYS A 1 236 ? -33.800 -22.198 -92.938 1.00 84.04 ? 267 LYS A CD 1 ATOM 1911 C CE . LYS A 1 236 ? -34.528 -22.851 -91.771 1.00 93.57 ? 267 LYS A CE 1 ATOM 1912 N NZ . LYS A 1 236 ? -35.944 -22.396 -91.672 1.00 86.52 ? 267 LYS A NZ 1 ATOM 1913 N N . ASP A 1 237 ? -29.244 -24.206 -92.979 1.00 51.42 ? 268 ASP A N 1 ATOM 1914 C CA . ASP A 1 237 ? -28.786 -24.964 -94.137 1.00 52.57 ? 268 ASP A CA 1 ATOM 1915 C C . ASP A 1 237 ? -27.989 -26.207 -93.747 1.00 53.02 ? 268 ASP A C 1 ATOM 1916 O O . ASP A 1 237 ? -27.728 -27.071 -94.585 1.00 58.21 ? 268 ASP A O 1 ATOM 1917 C CB . ASP A 1 237 ? -27.945 -24.069 -95.055 1.00 66.42 ? 268 ASP A CB 1 ATOM 1918 C CG . ASP A 1 237 ? -27.606 -24.739 -96.376 1.00 92.40 ? 268 ASP A CG 1 ATOM 1919 O OD1 . ASP A 1 237 ? -28.480 -24.769 -97.271 1.00 83.33 ? 268 ASP A OD1 1 ATOM 1920 O OD2 . ASP A 1 237 ? -26.467 -25.233 -96.521 1.00 66.47 ? 268 ASP A OD2 1 ATOM 1921 N N . THR A 1 238 ? -27.613 -26.309 -92.476 1.00 50.07 ? 269 THR A N 1 ATOM 1922 C CA . THR A 1 238 ? -26.754 -27.408 -92.041 1.00 50.41 ? 269 THR A CA 1 ATOM 1923 C C . THR A 1 238 ? -27.368 -28.264 -90.934 1.00 49.89 ? 269 THR A C 1 ATOM 1924 O O . THR A 1 238 ? -27.002 -29.428 -90.780 1.00 47.49 ? 269 THR A O 1 ATOM 1925 C CB . THR A 1 238 ? -25.391 -26.883 -91.550 1.00 44.41 ? 269 THR A CB 1 ATOM 1926 O OG1 . THR A 1 238 ? -25.594 -25.949 -90.482 1.00 45.53 ? 269 THR A OG1 1 ATOM 1927 C CG2 . THR A 1 238 ? -24.648 -26.200 -92.681 1.00 40.47 ? 269 THR A CG2 1 ATOM 1928 N N . GLN A 1 239 ? -28.288 -27.675 -90.173 1.00 47.43 ? 270 GLN A N 1 ATOM 1929 C CA . GLN A 1 239 ? -28.950 -28.336 -89.043 1.00 47.66 ? 270 GLN A CA 1 ATOM 1930 C C . GLN A 1 239 ? -28.009 -28.704 -87.898 1.00 48.21 ? 270 GLN A C 1 ATOM 1931 O O . GLN A 1 239 ? -28.319 -29.601 -87.116 1.00 55.55 ? 270 GLN A O 1 ATOM 1932 C CB . GLN A 1 239 ? -29.686 -29.603 -89.499 1.00 53.58 ? 270 GLN A CB 1 ATOM 1933 C CG . GLN A 1 239 ? -31.184 -29.437 -89.667 1.00 65.92 ? 270 GLN A CG 1 ATOM 1934 C CD . GLN A 1 239 ? -31.558 -28.914 -91.034 1.00 91.08 ? 270 GLN A CD 1 ATOM 1935 O OE1 . GLN A 1 239 ? -31.346 -29.583 -92.046 1.00 85.18 ? 270 GLN A OE1 1 ATOM 1936 N NE2 . GLN A 1 239 ? -32.114 -27.708 -91.074 1.00 84.27 ? 270 GLN A NE2 1 ATOM 1937 N N . VAL A 1 240 ? -26.870 -28.026 -87.786 1.00 46.72 ? 271 VAL A N 1 ATOM 1938 C CA . VAL A 1 240 ? -25.990 -28.278 -86.648 1.00 53.80 ? 271 VAL A CA 1 ATOM 1939 C C . VAL A 1 240 ? -26.425 -27.408 -85.474 1.00 52.99 ? 271 VAL A C 1 ATOM 1940 O O . VAL A 1 240 ? -26.991 -26.329 -85.662 1.00 56.18 ? 271 VAL A O 1 ATOM 1941 C CB . VAL A 1 240 ? -24.494 -28.023 -86.979 1.00 49.54 ? 271 VAL A CB 1 ATOM 1942 C CG1 . VAL A 1 240 ? -24.236 -28.214 -88.458 1.00 42.60 ? 271 VAL A CG1 1 ATOM 1943 C CG2 . VAL A 1 240 ? -24.052 -26.638 -86.529 1.00 52.06 ? 271 VAL A CG2 1 ATOM 1944 N N . GLU A 1 241 ? -26.178 -27.894 -84.263 1.00 57.30 ? 272 GLU A N 1 ATOM 1945 C CA . GLU A 1 241 ? -26.582 -27.174 -83.064 1.00 60.64 ? 272 GLU A CA 1 ATOM 1946 C C . GLU A 1 241 ? -25.585 -26.082 -82.697 1.00 57.02 ? 272 GLU A C 1 ATOM 1947 O O . GLU A 1 241 ? -24.409 -26.352 -82.452 1.00 63.61 ? 272 GLU A O 1 ATOM 1948 C CB . GLU A 1 241 ? -26.753 -28.137 -81.887 1.00 63.23 ? 272 GLU A CB 1 ATOM 1949 C CG . GLU A 1 241 ? -28.065 -28.905 -81.895 1.00 76.76 ? 272 GLU A CG 1 ATOM 1950 C CD . GLU A 1 241 ? -28.277 -29.702 -80.623 1.00 100.47 ? 272 GLU A CD 1 ATOM 1951 O OE1 . GLU A 1 241 ? -29.430 -30.096 -80.350 1.00 93.55 ? 272 GLU A OE1 1 ATOM 1952 O OE2 . GLU A 1 241 ? -27.289 -29.935 -79.894 1.00 92.19 ? 272 GLU A OE2 1 ATOM 1953 N N . MET A 1 242 ? -26.070 -24.846 -82.667 1.00 50.74 ? 273 MET A N 1 ATOM 1954 C CA . MET A 1 242 ? -25.282 -23.717 -82.196 1.00 52.28 ? 273 MET A CA 1 ATOM 1955 C C . MET A 1 242 ? -26.003 -23.055 -81.030 1.00 53.74 ? 273 MET A C 1 ATOM 1956 O O . MET A 1 242 ? -27.223 -23.163 -80.907 1.00 56.84 ? 273 MET A O 1 ATOM 1957 C CB . MET A 1 242 ? -25.047 -22.705 -83.319 1.00 54.03 ? 273 MET A CB 1 ATOM 1958 C CG . MET A 1 242 ? -24.217 -23.226 -84.483 1.00 51.53 ? 273 MET A CG 1 ATOM 1959 S SD . MET A 1 242 ? -22.489 -23.520 -84.053 1.00 45.79 ? 273 MET A SD 1 ATOM 1960 C CE . MET A 1 242 ? -22.010 -21.917 -83.415 1.00 47.26 ? 273 MET A CE 1 ATOM 1961 N N . ILE A 1 243 ? -25.250 -22.375 -80.173 1.00 54.56 ? 274 ILE A N 1 ATOM 1962 C CA . ILE A 1 243 ? -25.842 -21.680 -79.038 1.00 53.84 ? 274 ILE A CA 1 ATOM 1963 C C . ILE A 1 243 ? -26.057 -20.203 -79.357 1.00 61.44 ? 274 ILE A C 1 ATOM 1964 O O . ILE A 1 243 ? -25.135 -19.393 -79.264 1.00 69.92 ? 274 ILE A O 1 ATOM 1965 C CB . ILE A 1 243 ? -24.971 -21.811 -77.774 1.00 51.88 ? 274 ILE A CB 1 ATOM 1966 C CG1 . ILE A 1 243 ? -24.744 -23.285 -77.435 1.00 54.04 ? 274 ILE A CG1 1 ATOM 1967 C CG2 . ILE A 1 243 ? -25.617 -21.089 -76.601 1.00 50.41 ? 274 ILE A CG2 1 ATOM 1968 C CD1 . ILE A 1 243 ? -23.928 -23.504 -76.179 1.00 58.51 ? 274 ILE A CD1 1 ATOM 1969 N N . TYR A 1 244 ? -27.281 -19.867 -79.750 1.00 63.75 ? 275 TYR A N 1 ATOM 1970 C CA . TYR A 1 244 ? -27.655 -18.483 -80.015 1.00 64.88 ? 275 TYR A CA 1 ATOM 1971 C C . TYR A 1 244 ? -28.900 -18.106 -79.224 1.00 67.64 ? 275 TYR A C 1 ATOM 1972 O O . TYR A 1 244 ? -29.812 -18.919 -79.076 1.00 80.88 ? 275 TYR A O 1 ATOM 1973 C CB . TYR A 1 244 ? -27.908 -18.254 -81.509 1.00 66.54 ? 275 TYR A CB 1 ATOM 1974 C CG . TYR A 1 244 ? -26.666 -18.273 -82.372 1.00 58.37 ? 275 TYR A CG 1 ATOM 1975 C CD1 . TYR A 1 244 ? -25.713 -17.269 -82.273 1.00 60.98 ? 275 TYR A CD1 1 ATOM 1976 C CD2 . TYR A 1 244 ? -26.458 -19.283 -83.300 1.00 57.46 ? 275 TYR A CD2 1 ATOM 1977 C CE1 . TYR A 1 244 ? -24.578 -17.279 -83.064 1.00 56.52 ? 275 TYR A CE1 1 ATOM 1978 C CE2 . TYR A 1 244 ? -25.327 -19.302 -84.097 1.00 53.24 ? 275 TYR A CE2 1 ATOM 1979 C CZ . TYR A 1 244 ? -24.391 -18.298 -83.974 1.00 54.74 ? 275 TYR A CZ 1 ATOM 1980 O OH . TYR A 1 244 ? -23.264 -18.313 -84.764 1.00 52.30 ? 275 TYR A OH 1 ATOM 1981 N N . PRO A 1 245 ? -28.940 -16.870 -78.708 1.00 73.64 ? 276 PRO A N 1 ATOM 1982 C CA . PRO A 1 245 ? -30.169 -16.357 -78.095 1.00 81.01 ? 276 PRO A CA 1 ATOM 1983 C C . PRO A 1 245 ? -31.301 -16.323 -79.122 1.00 84.69 ? 276 PRO A C 1 ATOM 1984 O O . PRO A 1 245 ? -31.033 -16.146 -80.312 1.00 76.66 ? 276 PRO A O 1 ATOM 1985 C CB . PRO A 1 245 ? -29.777 -14.948 -77.634 1.00 78.66 ? 276 PRO A CB 1 ATOM 1986 C CG . PRO A 1 245 ? -28.565 -14.598 -78.430 1.00 77.55 ? 276 PRO A CG 1 ATOM 1987 C CD . PRO A 1 245 ? -27.846 -15.886 -78.668 1.00 76.15 ? 276 PRO A CD 1 ATOM 1988 N N . PRO A 1 246 ? -32.552 -16.498 -78.670 1.00 93.51 ? 277 PRO A N 1 ATOM 1989 C CA . PRO A 1 246 ? -33.705 -16.671 -79.565 1.00 85.71 ? 277 PRO A CA 1 ATOM 1990 C C . PRO A 1 246 ? -33.971 -15.502 -80.517 1.00 83.20 ? 277 PRO A C 1 ATOM 1991 O O . PRO A 1 246 ? -34.716 -15.679 -81.481 1.00 83.99 ? 277 PRO A O 1 ATOM 1992 C CB . PRO A 1 246 ? -34.878 -16.837 -78.590 1.00 89.33 ? 277 PRO A CB 1 ATOM 1993 C CG . PRO A 1 246 ? -34.410 -16.222 -77.312 1.00 82.67 ? 277 PRO A CG 1 ATOM 1994 C CD . PRO A 1 246 ? -32.949 -16.529 -77.252 1.00 83.31 ? 277 PRO A CD 1 ATOM 1995 N N . HIS A 1 247 ? -33.375 -14.341 -80.264 1.00 81.00 ? 278 HIS A N 1 ATOM 1996 C CA . HIS A 1 247 ? -33.679 -13.150 -81.055 1.00 81.75 ? 278 HIS A CA 1 ATOM 1997 C C . HIS A 1 247 ? -32.731 -12.943 -82.239 1.00 83.67 ? 278 HIS A C 1 ATOM 1998 O O . HIS A 1 247 ? -32.839 -11.948 -82.956 1.00 79.27 ? 278 HIS A O 1 ATOM 1999 C CB . HIS A 1 247 ? -33.660 -11.907 -80.161 1.00 87.75 ? 278 HIS A CB 1 ATOM 2000 C CG . HIS A 1 247 ? -32.303 -11.563 -79.628 1.00 99.49 ? 278 HIS A CG 1 ATOM 2001 N ND1 . HIS A 1 247 ? -31.884 -11.927 -78.366 1.00 93.77 ? 278 HIS A ND1 1 ATOM 2002 C CD2 . HIS A 1 247 ? -31.274 -10.881 -80.184 1.00 95.01 ? 278 HIS A CD2 1 ATOM 2003 C CE1 . HIS A 1 247 ? -30.654 -11.488 -78.169 1.00 91.18 ? 278 HIS A CE1 1 ATOM 2004 N NE2 . HIS A 1 247 ? -30.260 -10.850 -79.257 1.00 90.81 ? 278 HIS A NE2 1 ATOM 2005 N N . ILE A 1 248 ? -31.808 -13.877 -82.444 1.00 87.04 ? 279 ILE A N 1 ATOM 2006 C CA . ILE A 1 248 ? -30.845 -13.769 -83.537 1.00 77.71 ? 279 ILE A CA 1 ATOM 2007 C C . ILE A 1 248 ? -31.465 -14.192 -84.865 1.00 76.39 ? 279 ILE A C 1 ATOM 2008 O O . ILE A 1 248 ? -32.069 -15.260 -84.956 1.00 76.19 ? 279 ILE A O 1 ATOM 2009 C CB . ILE A 1 248 ? -29.589 -14.625 -83.269 1.00 74.67 ? 279 ILE A CB 1 ATOM 2010 C CG1 . ILE A 1 248 ? -28.887 -14.157 -81.995 1.00 67.25 ? 279 ILE A CG1 1 ATOM 2011 C CG2 . ILE A 1 248 ? -28.629 -14.565 -84.452 1.00 68.09 ? 279 ILE A CG2 1 ATOM 2012 C CD1 . ILE A 1 248 ? -28.380 -12.736 -82.068 1.00 75.10 ? 279 ILE A CD1 1 ATOM 2013 N N . PRO A 1 249 ? -31.321 -13.344 -85.900 1.00 77.08 ? 280 PRO A N 1 ATOM 2014 C CA . PRO A 1 249 ? -31.807 -13.622 -87.257 1.00 79.15 ? 280 PRO A CA 1 ATOM 2015 C C . PRO A 1 249 ? -31.294 -14.946 -87.819 1.00 87.41 ? 280 PRO A C 1 ATOM 2016 O O . PRO A 1 249 ? -30.255 -15.446 -87.384 1.00 96.40 ? 280 PRO A O 1 ATOM 2017 C CB . PRO A 1 249 ? -31.259 -12.446 -88.070 1.00 78.33 ? 280 PRO A CB 1 ATOM 2018 C CG . PRO A 1 249 ? -31.143 -11.342 -87.085 1.00 79.72 ? 280 PRO A CG 1 ATOM 2019 C CD . PRO A 1 249 ? -30.741 -11.993 -85.792 1.00 82.19 ? 280 PRO A CD 1 ATOM 2020 N N . GLU A 1 250 ? -32.024 -15.499 -88.782 1.00 89.71 ? 281 GLU A N 1 ATOM 2021 C CA . GLU A 1 250 ? -31.663 -16.768 -89.404 1.00 84.92 ? 281 GLU A CA 1 ATOM 2022 C C . GLU A 1 250 ? -30.331 -16.688 -90.147 1.00 81.95 ? 281 GLU A C 1 ATOM 2023 O O . GLU A 1 250 ? -29.501 -17.592 -90.052 1.00 76.67 ? 281 GLU A O 1 ATOM 2024 C CB . GLU A 1 250 ? -32.772 -17.213 -90.361 1.00 101.87 ? 281 GLU A CB 1 ATOM 2025 C CG . GLU A 1 250 ? -32.355 -18.277 -91.359 1.00 111.16 ? 281 GLU A CG 1 ATOM 2026 C CD . GLU A 1 250 ? -33.492 -18.697 -92.268 1.00 114.46 ? 281 GLU A CD 1 ATOM 2027 O OE1 . GLU A 1 250 ? -33.262 -18.827 -93.489 1.00 100.43 ? 281 GLU A OE1 1 ATOM 2028 O OE2 . GLU A 1 250 ? -34.615 -18.900 -91.761 1.00 112.41 ? 281 GLU A OE2 1 ATOM 2029 N N . ASN A 1 251 ? -30.132 -15.598 -90.881 1.00 86.82 ? 282 ASN A N 1 ATOM 2030 C CA . ASN A 1 251 ? -28.925 -15.419 -91.682 1.00 83.82 ? 282 ASN A CA 1 ATOM 2031 C C . ASN A 1 251 ? -27.667 -15.270 -90.831 1.00 75.07 ? 282 ASN A C 1 ATOM 2032 O O . ASN A 1 251 ? -26.559 -15.522 -91.303 1.00 60.25 ? 282 ASN A O 1 ATOM 2033 C CB . ASN A 1 251 ? -29.069 -14.199 -92.594 1.00 91.30 ? 282 ASN A CB 1 ATOM 2034 C CG . ASN A 1 251 ? -30.469 -13.623 -92.581 1.00 99.75 ? 282 ASN A CG 1 ATOM 2035 O OD1 . ASN A 1 251 ? -31.454 -14.345 -92.740 1.00 123.91 ? 282 ASN A OD1 1 ATOM 2036 N ND2 . ASN A 1 251 ? -30.567 -12.314 -92.383 1.00 83.14 ? 282 ASN A ND2 1 ATOM 2037 N N . LEU A 1 252 ? -27.845 -14.862 -89.576 1.00 70.52 ? 283 LEU A N 1 ATOM 2038 C CA . LEU A 1 252 ? -26.715 -14.585 -88.693 1.00 60.73 ? 283 LEU A CA 1 ATOM 2039 C C . LEU A 1 252 ? -26.380 -15.741 -87.755 1.00 62.18 ? 283 LEU A C 1 ATOM 2040 O O . LEU A 1 252 ? -25.450 -15.647 -86.954 1.00 61.53 ? 283 LEU A O 1 ATOM 2041 C CB . LEU A 1 252 ? -26.987 -13.325 -87.872 1.00 67.69 ? 283 LEU A CB 1 ATOM 2042 C CG . LEU A 1 252 ? -26.905 -12.011 -88.650 1.00 61.94 ? 283 LEU A CG 1 ATOM 2043 C CD1 . LEU A 1 252 ? -27.201 -10.830 -87.743 1.00 60.70 ? 283 LEU A CD1 1 ATOM 2044 C CD2 . LEU A 1 252 ? -25.537 -11.867 -89.292 1.00 52.88 ? 283 LEU A CD2 1 ATOM 2045 N N . GLN A 1 253 ? -27.137 -16.828 -87.850 1.00 62.07 ? 284 GLN A N 1 ATOM 2046 C CA . GLN A 1 253 ? -26.844 -18.013 -87.056 1.00 56.86 ? 284 GLN A CA 1 ATOM 2047 C C . GLN A 1 253 ? -25.778 -18.861 -87.744 1.00 49.06 ? 284 GLN A C 1 ATOM 2048 O O . GLN A 1 253 ? -26.082 -19.867 -88.386 1.00 50.23 ? 284 GLN A O 1 ATOM 2049 C CB . GLN A 1 253 ? -28.114 -18.829 -86.813 1.00 63.14 ? 284 GLN A CB 1 ATOM 2050 C CG . GLN A 1 253 ? -29.063 -18.198 -85.802 1.00 70.31 ? 284 GLN A CG 1 ATOM 2051 C CD . GLN A 1 253 ? -30.278 -19.059 -85.527 1.00 71.98 ? 284 GLN A CD 1 ATOM 2052 O OE1 . GLN A 1 253 ? -30.919 -19.560 -86.451 1.00 66.24 ? 284 GLN A OE1 1 ATOM 2053 N NE2 . GLN A 1 253 ? -30.596 -19.245 -84.250 1.00 68.90 ? 284 GLN A NE2 1 ATOM 2054 N N . PHE A 1 254 ? -24.526 -18.440 -87.606 1.00 45.01 ? 285 PHE A N 1 ATOM 2055 C CA . PHE A 1 254 ? -23.404 -19.130 -88.231 1.00 43.89 ? 285 PHE A CA 1 ATOM 2056 C C . PHE A 1 254 ? -23.140 -20.493 -87.595 1.00 47.15 ? 285 PHE A C 1 ATOM 2057 O O . PHE A 1 254 ? -23.149 -20.633 -86.371 1.00 39.79 ? 285 PHE A O 1 ATOM 2058 C CB . PHE A 1 254 ? -22.146 -18.266 -88.153 1.00 41.17 ? 285 PHE A CB 1 ATOM 2059 C CG . PHE A 1 254 ? -22.196 -17.041 -89.020 1.00 46.32 ? 285 PHE A CG 1 ATOM 2060 C CD1 . PHE A 1 254 ? -22.779 -17.085 -90.277 1.00 49.18 ? 285 PHE A CD1 1 ATOM 2061 C CD2 . PHE A 1 254 ? -21.662 -15.843 -88.577 1.00 53.98 ? 285 PHE A CD2 1 ATOM 2062 C CE1 . PHE A 1 254 ? -22.823 -15.957 -91.077 1.00 45.46 ? 285 PHE A CE1 1 ATOM 2063 C CE2 . PHE A 1 254 ? -21.705 -14.712 -89.371 1.00 55.59 ? 285 PHE A CE2 1 ATOM 2064 C CZ . PHE A 1 254 ? -22.285 -14.769 -90.621 1.00 47.49 ? 285 PHE A CZ 1 ATOM 2065 N N . ALA A 1 255 ? -22.899 -21.492 -88.437 1.00 43.26 ? 286 ALA A N 1 ATOM 2066 C CA . ALA A 1 255 ? -22.648 -22.848 -87.965 1.00 33.61 ? 286 ALA A CA 1 ATOM 2067 C C . ALA A 1 255 ? -21.184 -23.237 -88.148 1.00 40.32 ? 286 ALA A C 1 ATOM 2068 O O . ALA A 1 255 ? -20.706 -23.383 -89.275 1.00 43.26 ? 286 ALA A O 1 ATOM 2069 C CB . ALA A 1 255 ? -23.551 -23.831 -88.690 1.00 29.40 ? 286 ALA A CB 1 ATOM 2070 N N . VAL A 1 256 ? -20.474 -23.405 -87.036 1.00 37.81 ? 287 VAL A N 1 ATOM 2071 C CA . VAL A 1 256 ? -19.075 -23.821 -87.077 1.00 39.10 ? 287 VAL A CA 1 ATOM 2072 C C . VAL A 1 256 ? -18.851 -25.062 -86.217 1.00 40.78 ? 287 VAL A C 1 ATOM 2073 O O . VAL A 1 256 ? -19.790 -25.586 -85.615 1.00 41.23 ? 287 VAL A O 1 ATOM 2074 C CB . VAL A 1 256 ? -18.135 -22.695 -86.608 1.00 32.55 ? 287 VAL A CB 1 ATOM 2075 C CG1 . VAL A 1 256 ? -18.143 -21.550 -87.606 1.00 30.71 ? 287 VAL A CG1 1 ATOM 2076 C CG2 . VAL A 1 256 ? -18.538 -22.205 -85.230 1.00 35.65 ? 287 VAL A CG2 1 ATOM 2077 N N . GLY A 1 257 ? -17.605 -25.527 -86.169 1.00 31.64 ? 288 GLY A N 1 ATOM 2078 C CA . GLY A 1 257 ? -17.253 -26.719 -85.417 1.00 33.41 ? 288 GLY A CA 1 ATOM 2079 C C . GLY A 1 257 ? -17.662 -26.652 -83.958 1.00 35.97 ? 288 GLY A C 1 ATOM 2080 O O . GLY A 1 257 ? -18.443 -27.479 -83.489 1.00 38.85 ? 288 GLY A O 1 ATOM 2081 N N . GLN A 1 258 ? -17.137 -25.664 -83.241 1.00 36.84 ? 289 GLN A N 1 ATOM 2082 C CA . GLN A 1 258 ? -17.491 -25.456 -81.841 1.00 37.67 ? 289 GLN A CA 1 ATOM 2083 C C . GLN A 1 258 ? -18.804 -24.690 -81.730 1.00 43.89 ? 289 GLN A C 1 ATOM 2084 O O . GLN A 1 258 ? -19.016 -23.702 -82.429 1.00 54.13 ? 289 GLN A O 1 ATOM 2085 C CB . GLN A 1 258 ? -16.376 -24.707 -81.111 1.00 41.05 ? 289 GLN A CB 1 ATOM 2086 C CG . GLN A 1 258 ? -15.781 -25.453 -79.926 1.00 39.86 ? 289 GLN A CG 1 ATOM 2087 C CD . GLN A 1 258 ? -16.621 -25.332 -78.669 1.00 45.52 ? 289 GLN A CD 1 ATOM 2088 O OE1 . GLN A 1 258 ? -17.832 -25.112 -78.730 1.00 47.48 ? 289 GLN A OE1 1 ATOM 2089 N NE2 . GLN A 1 258 ? -15.976 -25.468 -77.516 1.00 51.76 ? 289 GLN A NE2 1 ATOM 2090 N N . GLU A 1 259 ? -19.678 -25.142 -80.838 1.00 51.96 ? 290 GLU A N 1 ATOM 2091 C CA . GLU A 1 259 ? -21.036 -24.612 -80.757 1.00 53.95 ? 290 GLU A CA 1 ATOM 2092 C C . GLU A 1 259 ? -21.138 -23.281 -80.009 1.00 50.37 ? 290 GLU A C 1 ATOM 2093 O O . GLU A 1 259 ? -22.149 -22.585 -80.113 1.00 57.10 ? 290 GLU A O 1 ATOM 2094 C CB . GLU A 1 259 ? -21.954 -25.647 -80.101 1.00 58.51 ? 290 GLU A CB 1 ATOM 2095 C CG . GLU A 1 259 ? -21.490 -26.112 -78.729 1.00 65.87 ? 290 GLU A CG 1 ATOM 2096 C CD . GLU A 1 259 ? -21.978 -27.509 -78.393 1.00 91.79 ? 290 GLU A CD 1 ATOM 2097 O OE1 . GLU A 1 259 ? -22.206 -28.302 -79.331 1.00 85.35 ? 290 GLU A OE1 1 ATOM 2098 O OE2 . GLU A 1 259 ? -22.133 -27.814 -77.191 1.00 90.08 ? 290 GLU A OE2 1 ATOM 2099 N N . VAL A 1 260 ? -20.097 -22.923 -79.264 1.00 48.77 ? 291 VAL A N 1 ATOM 2100 C CA . VAL A 1 260 ? -20.124 -21.691 -78.478 1.00 47.73 ? 291 VAL A CA 1 ATOM 2101 C C . VAL A 1 260 ? -19.387 -20.544 -79.159 1.00 51.14 ? 291 VAL A C 1 ATOM 2102 O O . VAL A 1 260 ? -19.205 -19.483 -78.566 1.00 54.65 ? 291 VAL A O 1 ATOM 2103 C CB . VAL A 1 260 ? -19.506 -21.892 -77.078 1.00 40.50 ? 291 VAL A CB 1 ATOM 2104 C CG1 . VAL A 1 260 ? -20.249 -22.978 -76.320 1.00 60.30 ? 291 VAL A CG1 1 ATOM 2105 C CG2 . VAL A 1 260 ? -18.025 -22.224 -77.190 1.00 42.59 ? 291 VAL A CG2 1 ATOM 2106 N N . PHE A 1 261 ? -18.967 -20.749 -80.403 1.00 48.25 ? 292 PHE A N 1 ATOM 2107 C CA . PHE A 1 261 ? -18.174 -19.738 -81.097 1.00 41.15 ? 292 PHE A CA 1 ATOM 2108 C C . PHE A 1 261 ? -19.030 -18.608 -81.660 1.00 50.26 ? 292 PHE A C 1 ATOM 2109 O O . PHE A 1 261 ? -18.508 -17.668 -82.260 1.00 52.01 ? 292 PHE A O 1 ATOM 2110 C CB . PHE A 1 261 ? -17.345 -20.378 -82.212 1.00 42.14 ? 292 PHE A CB 1 ATOM 2111 C CG . PHE A 1 261 ? -16.075 -21.016 -81.726 1.00 42.02 ? 292 PHE A CG 1 ATOM 2112 C CD1 . PHE A 1 261 ? -15.705 -20.917 -80.393 1.00 40.15 ? 292 PHE A CD1 1 ATOM 2113 C CD2 . PHE A 1 261 ? -15.246 -21.702 -82.597 1.00 36.77 ? 292 PHE A CD2 1 ATOM 2114 C CE1 . PHE A 1 261 ? -14.540 -21.497 -79.937 1.00 34.66 ? 292 PHE A CE1 1 ATOM 2115 C CE2 . PHE A 1 261 ? -14.076 -22.286 -82.147 1.00 41.19 ? 292 PHE A CE2 1 ATOM 2116 C CZ . PHE A 1 261 ? -13.722 -22.183 -80.814 1.00 38.96 ? 292 PHE A CZ 1 ATOM 2117 N N . GLY A 1 262 ? -20.342 -18.700 -81.461 1.00 52.49 ? 293 GLY A N 1 ATOM 2118 C CA . GLY A 1 262 ? -21.243 -17.625 -81.834 1.00 54.47 ? 293 GLY A CA 1 ATOM 2119 C C . GLY A 1 262 ? -21.316 -16.579 -80.736 1.00 56.95 ? 293 GLY A C 1 ATOM 2120 O O . GLY A 1 262 ? -21.821 -15.475 -80.942 1.00 55.62 ? 293 GLY A O 1 ATOM 2121 N N . LEU A 1 263 ? -20.800 -16.944 -79.566 1.00 61.57 ? 294 LEU A N 1 ATOM 2122 C CA . LEU A 1 263 ? -20.784 -16.077 -78.394 1.00 64.57 ? 294 LEU A CA 1 ATOM 2123 C C . LEU A 1 263 ? -20.082 -14.750 -78.669 1.00 61.16 ? 294 LEU A C 1 ATOM 2124 O O . LEU A 1 263 ? -20.614 -13.681 -78.366 1.00 57.65 ? 294 LEU A O 1 ATOM 2125 C CB . LEU A 1 263 ? -20.103 -16.797 -77.224 1.00 68.03 ? 294 LEU A CB 1 ATOM 2126 C CG . LEU A 1 263 ? -19.864 -16.043 -75.912 1.00 72.09 ? 294 LEU A CG 1 ATOM 2127 C CD1 . LEU A 1 263 ? -21.152 -15.886 -75.121 1.00 68.53 ? 294 LEU A CD1 1 ATOM 2128 C CD2 . LEU A 1 263 ? -18.796 -16.743 -75.078 1.00 49.77 ? 294 LEU A CD2 1 ATOM 2129 N N . VAL A 1 264 ? -18.886 -14.829 -79.244 1.00 53.76 ? 295 VAL A N 1 ATOM 2130 C CA . VAL A 1 264 ? -18.074 -13.645 -79.495 1.00 51.31 ? 295 VAL A CA 1 ATOM 2131 C C . VAL A 1 264 ? -17.756 -13.506 -80.981 1.00 48.58 ? 295 VAL A C 1 ATOM 2132 O O . VAL A 1 264 ? -17.394 -14.486 -81.632 1.00 53.40 ? 295 VAL A O 1 ATOM 2133 C CB . VAL A 1 264 ? -16.748 -13.690 -78.700 1.00 50.24 ? 295 VAL A CB 1 ATOM 2134 C CG1 . VAL A 1 264 ? -16.241 -12.287 -78.426 1.00 50.73 ? 295 VAL A CG1 1 ATOM 2135 C CG2 . VAL A 1 264 ? -16.932 -14.441 -77.397 1.00 60.58 ? 295 VAL A CG2 1 ATOM 2136 N N . PRO A 1 265 ? -17.898 -12.286 -81.524 1.00 45.66 ? 296 PRO A N 1 ATOM 2137 C CA . PRO A 1 265 ? -17.503 -11.996 -82.907 1.00 42.08 ? 296 PRO A CA 1 ATOM 2138 C C . PRO A 1 265 ? -16.014 -12.227 -83.129 1.00 40.36 ? 296 PRO A C 1 ATOM 2139 O O . PRO A 1 265 ? -15.602 -12.529 -84.251 1.00 34.82 ? 296 PRO A O 1 ATOM 2140 C CB . PRO A 1 265 ? -17.852 -10.514 -83.071 1.00 41.16 ? 296 PRO A CB 1 ATOM 2141 C CG . PRO A 1 265 ? -18.902 -10.260 -82.055 1.00 44.49 ? 296 PRO A CG 1 ATOM 2142 C CD . PRO A 1 265 ? -18.549 -11.130 -80.888 1.00 45.12 ? 296 PRO A CD 1 ATOM 2143 N N . GLY A 1 266 ? -15.223 -12.076 -82.069 1.00 37.34 ? 297 GLY A N 1 ATOM 2144 C CA . GLY A 1 266 ? -13.794 -12.326 -82.135 1.00 35.86 ? 297 GLY A CA 1 ATOM 2145 C C . GLY A 1 266 ? -13.481 -13.781 -82.426 1.00 40.12 ? 297 GLY A C 1 ATOM 2146 O O . GLY A 1 266 ? -12.542 -14.090 -83.160 1.00 38.12 ? 297 GLY A O 1 ATOM 2147 N N . LEU A 1 267 ? -14.275 -14.678 -81.849 1.00 39.62 ? 298 LEU A N 1 ATOM 2148 C CA . LEU A 1 267 ? -14.115 -16.111 -82.074 1.00 35.52 ? 298 LEU A CA 1 ATOM 2149 C C . LEU A 1 267 ? -14.578 -16.502 -83.472 1.00 34.90 ? 298 LEU A C 1 ATOM 2150 O O . LEU A 1 267 ? -13.947 -17.318 -84.144 1.00 36.38 ? 298 LEU A O 1 ATOM 2151 C CB . LEU A 1 267 ? -14.887 -16.907 -81.021 1.00 40.85 ? 298 LEU A CB 1 ATOM 2152 C CG . LEU A 1 267 ? -14.391 -16.776 -79.580 1.00 50.12 ? 298 LEU A CG 1 ATOM 2153 C CD1 . LEU A 1 267 ? -15.281 -17.567 -78.640 1.00 43.31 ? 298 LEU A CD1 1 ATOM 2154 C CD2 . LEU A 1 267 ? -12.946 -17.235 -79.468 1.00 43.44 ? 298 LEU A CD2 1 ATOM 2155 N N . MET A 1 268 ? -15.683 -15.909 -83.906 1.00 33.87 ? 299 MET A N 1 ATOM 2156 C CA . MET A 1 268 ? -16.237 -16.195 -85.221 1.00 33.63 ? 299 MET A CA 1 ATOM 2157 C C . MET A 1 268 ? -15.299 -15.698 -86.322 1.00 34.78 ? 299 MET A C 1 ATOM 2158 O O . MET A 1 268 ? -15.315 -16.209 -87.444 1.00 29.58 ? 299 MET A O 1 ATOM 2159 C CB . MET A 1 268 ? -17.623 -15.563 -85.358 1.00 34.45 ? 299 MET A CB 1 ATOM 2160 C CG . MET A 1 268 ? -18.385 -15.987 -86.598 1.00 39.73 ? 299 MET A CG 1 ATOM 2161 S SD . MET A 1 268 ? -18.694 -17.761 -86.652 1.00 42.13 ? 299 MET A SD 1 ATOM 2162 C CE . MET A 1 268 ? -19.754 -17.970 -85.226 1.00 39.63 ? 299 MET A CE 1 ATOM 2163 N N . MET A 1 269 ? -14.478 -14.705 -85.993 1.00 35.74 ? 300 MET A N 1 ATOM 2164 C CA . MET A 1 269 ? -13.472 -14.212 -86.925 1.00 32.21 ? 300 MET A CA 1 ATOM 2165 C C . MET A 1 269 ? -12.480 -15.316 -87.273 1.00 36.76 ? 300 MET A C 1 ATOM 2166 O O . MET A 1 269 ? -12.220 -15.581 -88.448 1.00 36.30 ? 300 MET A O 1 ATOM 2167 C CB . MET A 1 269 ? -12.728 -13.009 -86.343 1.00 30.22 ? 300 MET A CB 1 ATOM 2168 C CG . MET A 1 269 ? -11.569 -12.536 -87.211 1.00 28.74 ? 300 MET A CG 1 ATOM 2169 S SD . MET A 1 269 ? -10.504 -11.320 -86.413 1.00 36.79 ? 300 MET A SD 1 ATOM 2170 C CE . MET A 1 269 ? -9.938 -12.238 -84.982 1.00 31.18 ? 300 MET A CE 1 ATOM 2171 N N . TYR A 1 270 ? -11.930 -15.957 -86.247 1.00 35.14 ? 301 TYR A N 1 ATOM 2172 C CA . TYR A 1 270 ? -10.963 -17.027 -86.454 1.00 33.02 ? 301 TYR A CA 1 ATOM 2173 C C . TYR A 1 270 ? -11.631 -18.270 -87.028 1.00 33.50 ? 301 TYR A C 1 ATOM 2174 O O . TYR A 1 270 ? -11.026 -19.001 -87.813 1.00 32.68 ? 301 TYR A O 1 ATOM 2175 C CB . TYR A 1 270 ? -10.240 -17.362 -85.149 1.00 23.81 ? 301 TYR A CB 1 ATOM 2176 C CG . TYR A 1 270 ? -9.029 -16.492 -84.911 1.00 26.84 ? 301 TYR A CG 1 ATOM 2177 C CD1 . TYR A 1 270 ? -7.930 -16.563 -85.755 1.00 25.29 ? 301 TYR A CD1 1 ATOM 2178 C CD2 . TYR A 1 270 ? -8.983 -15.598 -83.849 1.00 29.66 ? 301 TYR A CD2 1 ATOM 2179 C CE1 . TYR A 1 270 ? -6.820 -15.770 -85.553 1.00 25.51 ? 301 TYR A CE1 1 ATOM 2180 C CE2 . TYR A 1 270 ? -7.874 -14.800 -83.636 1.00 28.20 ? 301 TYR A CE2 1 ATOM 2181 C CZ . TYR A 1 270 ? -6.795 -14.892 -84.493 1.00 28.23 ? 301 TYR A CZ 1 ATOM 2182 O OH . TYR A 1 270 ? -5.686 -14.104 -84.293 1.00 34.70 ? 301 TYR A OH 1 ATOM 2183 N N . ALA A 1 271 ? -12.880 -18.502 -86.639 1.00 27.77 ? 302 ALA A N 1 ATOM 2184 C CA . ALA A 1 271 ? -13.660 -19.597 -87.201 1.00 29.37 ? 302 ALA A CA 1 ATOM 2185 C C . ALA A 1 271 ? -13.812 -19.433 -88.710 1.00 32.60 ? 302 ALA A C 1 ATOM 2186 O O . ALA A 1 271 ? -13.801 -20.412 -89.457 1.00 37.26 ? 302 ALA A O 1 ATOM 2187 C CB . ALA A 1 271 ? -15.020 -19.674 -86.537 1.00 29.76 ? 302 ALA A CB 1 ATOM 2188 N N . THR A 1 272 ? -13.952 -18.185 -89.148 1.00 32.66 ? 303 THR A N 1 ATOM 2189 C CA . THR A 1 272 ? -14.106 -17.869 -90.563 1.00 29.89 ? 303 THR A CA 1 ATOM 2190 C C . THR A 1 272 ? -12.783 -17.999 -91.315 1.00 32.82 ? 303 THR A C 1 ATOM 2191 O O . THR A 1 272 ? -12.738 -18.541 -92.418 1.00 33.45 ? 303 THR A O 1 ATOM 2192 C CB . THR A 1 272 ? -14.663 -16.445 -90.756 1.00 26.05 ? 303 THR A CB 1 ATOM 2193 O OG1 . THR A 1 272 ? -15.956 -16.354 -90.146 1.00 33.58 ? 303 THR A OG1 1 ATOM 2194 C CG2 . THR A 1 272 ? -14.779 -16.103 -92.233 1.00 24.53 ? 303 THR A CG2 1 ATOM 2195 N N . ILE A 1 273 ? -11.709 -17.502 -90.710 1.00 27.90 ? 304 ILE A N 1 ATOM 2196 C CA . ILE A 1 273 ? -10.385 -17.560 -91.321 1.00 32.43 ? 304 ILE A CA 1 ATOM 2197 C C . ILE A 1 273 ? -9.940 -19.003 -91.569 1.00 32.90 ? 304 ILE A C 1 ATOM 2198 O O . ILE A 1 273 ? -9.444 -19.331 -92.649 1.00 31.79 ? 304 ILE A O 1 ATOM 2199 C CB . ILE A 1 273 ? -9.336 -16.842 -90.447 1.00 30.25 ? 304 ILE A CB 1 ATOM 2200 C CG1 . ILE A 1 273 ? -9.605 -15.336 -90.424 1.00 24.51 ? 304 ILE A CG1 1 ATOM 2201 C CG2 . ILE A 1 273 ? -7.931 -17.127 -90.950 1.00 23.85 ? 304 ILE A CG2 1 ATOM 2202 C CD1 . ILE A 1 273 ? -8.646 -14.559 -89.542 1.00 28.29 ? 304 ILE A CD1 1 ATOM 2203 N N . TRP A 1 274 ? -10.129 -19.864 -90.574 1.00 32.13 ? 305 TRP A N 1 ATOM 2204 C CA . TRP A 1 274 ? -9.742 -21.265 -90.702 1.00 29.76 ? 305 TRP A CA 1 ATOM 2205 C C . TRP A 1 274 ? -10.638 -22.015 -91.687 1.00 34.76 ? 305 TRP A C 1 ATOM 2206 O O . TRP A 1 274 ? -10.187 -22.938 -92.367 1.00 34.58 ? 305 TRP A O 1 ATOM 2207 C CB . TRP A 1 274 ? -9.770 -21.952 -89.340 1.00 26.75 ? 305 TRP A CB 1 ATOM 2208 C CG . TRP A 1 274 ? -8.589 -21.620 -88.478 1.00 28.48 ? 305 TRP A CG 1 ATOM 2209 C CD1 . TRP A 1 274 ? -8.586 -20.861 -87.343 1.00 22.31 ? 305 TRP A CD1 1 ATOM 2210 C CD2 . TRP A 1 274 ? -7.235 -22.037 -88.685 1.00 26.98 ? 305 TRP A CD2 1 ATOM 2211 N NE1 . TRP A 1 274 ? -7.314 -20.783 -86.829 1.00 22.77 ? 305 TRP A NE1 1 ATOM 2212 C CE2 . TRP A 1 274 ? -6.465 -21.496 -87.636 1.00 28.60 ? 305 TRP A CE2 1 ATOM 2213 C CE3 . TRP A 1 274 ? -6.598 -22.816 -89.656 1.00 27.29 ? 305 TRP A CE3 1 ATOM 2214 C CZ2 . TRP A 1 274 ? -5.092 -21.709 -87.530 1.00 27.50 ? 305 TRP A CZ2 1 ATOM 2215 C CZ3 . TRP A 1 274 ? -5.234 -23.026 -89.549 1.00 29.79 ? 305 TRP A CZ3 1 ATOM 2216 C CH2 . TRP A 1 274 ? -4.497 -22.475 -88.494 1.00 24.48 ? 305 TRP A CH2 1 ATOM 2217 N N . LEU A 1 275 ? -11.905 -21.619 -91.758 1.00 33.10 ? 306 LEU A N 1 ATOM 2218 C CA . LEU A 1 275 ? -12.828 -22.189 -92.731 1.00 26.55 ? 306 LEU A CA 1 ATOM 2219 C C . LEU A 1 275 ? -12.348 -21.909 -94.150 1.00 33.06 ? 306 LEU A C 1 ATOM 2220 O O . LEU A 1 275 ? -12.345 -22.798 -95.002 1.00 29.15 ? 306 LEU A O 1 ATOM 2221 C CB . LEU A 1 275 ? -14.236 -21.626 -92.537 1.00 30.92 ? 306 LEU A CB 1 ATOM 2222 C CG . LEU A 1 275 ? -15.198 -21.869 -93.705 1.00 32.81 ? 306 LEU A CG 1 ATOM 2223 C CD1 . LEU A 1 275 ? -15.500 -23.343 -93.847 1.00 28.01 ? 306 LEU A CD1 1 ATOM 2224 C CD2 . LEU A 1 275 ? -16.475 -21.082 -93.521 1.00 37.22 ? 306 LEU A CD2 1 ATOM 2225 N N . ARG A 1 276 ? -11.946 -20.665 -94.394 1.00 33.50 ? 307 ARG A N 1 ATOM 2226 C CA . ARG A 1 276 ? -11.410 -20.268 -95.689 1.00 26.43 ? 307 ARG A CA 1 ATOM 2227 C C . ARG A 1 276 ? -10.110 -21.006 -95.970 1.00 34.42 ? 307 ARG A C 1 ATOM 2228 O O . ARG A 1 276 ? -9.850 -21.418 -97.102 1.00 38.58 ? 307 ARG A O 1 ATOM 2229 C CB . ARG A 1 276 ? -11.178 -18.756 -95.743 1.00 25.13 ? 307 ARG A CB 1 ATOM 2230 C CG . ARG A 1 276 ? -12.434 -17.920 -95.555 1.00 27.08 ? 307 ARG A CG 1 ATOM 2231 C CD . ARG A 1 276 ? -12.100 -16.440 -95.539 1.00 22.85 ? 307 ARG A CD 1 ATOM 2232 N NE . ARG A 1 276 ? -13.267 -15.613 -95.249 1.00 28.17 ? 307 ARG A NE 1 ATOM 2233 C CZ . ARG A 1 276 ? -13.228 -14.291 -95.123 1.00 26.98 ? 307 ARG A CZ 1 ATOM 2234 N NH1 . ARG A 1 276 ? -12.079 -13.647 -95.261 1.00 28.91 ? 307 ARG A NH1 1 ATOM 2235 N NH2 . ARG A 1 276 ? -14.336 -13.613 -94.858 1.00 30.01 ? 307 ARG A NH2 1 ATOM 2236 N N . GLU A 1 277 ? -9.300 -21.175 -94.929 1.00 26.40 ? 308 GLU A N 1 ATOM 2237 C CA . GLU A 1 277 ? -8.007 -21.836 -95.062 1.00 29.57 ? 308 GLU A CA 1 ATOM 2238 C C . GLU A 1 277 ? -8.154 -23.308 -95.436 1.00 34.33 ? 308 GLU A C 1 ATOM 2239 O O . GLU A 1 277 ? -7.373 -23.830 -96.233 1.00 30.33 ? 308 GLU A O 1 ATOM 2240 C CB . GLU A 1 277 ? -7.201 -21.702 -93.767 1.00 25.75 ? 308 GLU A CB 1 ATOM 2241 C CG . GLU A 1 277 ? -5.881 -22.458 -93.765 1.00 27.90 ? 308 GLU A CG 1 ATOM 2242 C CD . GLU A 1 277 ? -4.921 -21.992 -94.846 1.00 31.79 ? 308 GLU A CD 1 ATOM 2243 O OE1 . GLU A 1 277 ? -4.021 -22.776 -95.216 1.00 31.52 ? 308 GLU A OE1 1 ATOM 2244 O OE2 . GLU A 1 277 ? -5.055 -20.844 -95.321 1.00 36.69 ? 308 GLU A OE2 1 ATOM 2245 N N . HIS A 1 278 ? -9.152 -23.974 -94.859 1.00 30.12 ? 309 HIS A N 1 ATOM 2246 C CA . HIS A 1 278 ? -9.413 -25.370 -95.188 1.00 27.66 ? 309 HIS A CA 1 ATOM 2247 C C . HIS A 1 278 ? -9.755 -25.523 -96.664 1.00 31.37 ? 309 HIS A C 1 ATOM 2248 O O . HIS A 1 278 ? -9.156 -26.337 -97.368 1.00 29.65 ? 309 HIS A O 1 ATOM 2249 C CB . HIS A 1 278 ? -10.549 -25.940 -94.337 1.00 30.28 ? 309 HIS A CB 1 ATOM 2250 C CG . HIS A 1 278 ? -10.926 -27.340 -94.711 1.00 34.07 ? 309 HIS A CG 1 ATOM 2251 N ND1 . HIS A 1 278 ? -10.356 -28.446 -94.119 1.00 35.13 ? 309 HIS A ND1 1 ATOM 2252 C CD2 . HIS A 1 278 ? -11.792 -27.815 -95.638 1.00 33.24 ? 309 HIS A CD2 1 ATOM 2253 C CE1 . HIS A 1 278 ? -10.865 -29.541 -94.654 1.00 34.55 ? 309 HIS A CE1 1 ATOM 2254 N NE2 . HIS A 1 278 ? -11.737 -29.186 -95.580 1.00 28.06 ? 309 HIS A NE2 1 ATOM 2255 N N . ASN A 1 279 ? -10.722 -24.735 -97.123 1.00 34.46 ? 310 ASN A N 1 ATOM 2256 C CA . ASN A 1 279 ? -11.139 -24.773 -98.519 1.00 33.72 ? 310 ASN A CA 1 ATOM 2257 C C . ASN A 1 279 ? -10.021 -24.315 -99.452 1.00 34.22 ? 310 ASN A C 1 ATOM 2258 O O . ASN A 1 279 ? -9.940 -24.757 -100.599 1.00 33.42 ? 310 ASN A O 1 ATOM 2259 C CB . ASN A 1 279 ? -12.390 -23.918 -98.729 1.00 27.80 ? 310 ASN A CB 1 ATOM 2260 C CG . ASN A 1 279 ? -13.608 -24.481 -98.017 1.00 36.91 ? 310 ASN A CG 1 ATOM 2261 O OD1 . ASN A 1 279 ? -13.627 -25.647 -97.619 1.00 34.00 ? 310 ASN A OD1 1 ATOM 2262 N ND2 . ASN A 1 279 ? -14.635 -23.655 -97.859 1.00 27.23 ? 310 ASN A ND2 1 ATOM 2263 N N . ARG A 1 280 ? -9.155 -23.437 -98.954 1.00 31.20 ? 311 ARG A N 1 ATOM 2264 C CA . ARG A 1 280 ? -8.004 -22.982 -99.727 1.00 29.60 ? 311 ARG A CA 1 ATOM 2265 C C . ARG A 1 280 ? -7.040 -24.134 -99.986 1.00 34.84 ? 311 ARG A C 1 ATOM 2266 O O . ARG A 1 280 ? -6.541 -24.301 -101.101 1.00 37.86 ? 311 ARG A O 1 ATOM 2267 C CB . ARG A 1 280 ? -7.274 -21.853 -99.004 1.00 25.99 ? 311 ARG A CB 1 ATOM 2268 C CG . ARG A 1 280 ? -6.124 -21.267 -99.797 1.00 23.23 ? 311 ARG A CG 1 ATOM 2269 C CD . ARG A 1 280 ? -5.308 -20.286 -98.972 1.00 25.82 ? 311 ARG A CD 1 ATOM 2270 N NE . ARG A 1 280 ? -4.328 -20.960 -98.127 1.00 33.12 ? 311 ARG A NE 1 ATOM 2271 C CZ . ARG A 1 280 ? -3.100 -21.281 -98.522 1.00 33.63 ? 311 ARG A CZ 1 ATOM 2272 N NH1 . ARG A 1 280 ? -2.702 -20.994 -99.754 1.00 36.04 ? 311 ARG A NH1 1 ATOM 2273 N NH2 . ARG A 1 280 ? -2.270 -21.892 -97.688 1.00 27.67 ? 311 ARG A NH2 1 ATOM 2274 N N . VAL A 1 281 ? -6.783 -24.923 -98.946 1.00 30.78 ? 312 VAL A N 1 ATOM 2275 C CA . VAL A 1 281 ? -5.882 -26.065 -99.050 1.00 30.70 ? 312 VAL A CA 1 ATOM 2276 C C . VAL A 1 281 ? -6.500 -27.148 -99.935 1.00 35.00 ? 312 VAL A C 1 ATOM 2277 O O . VAL A 1 281 ? -5.790 -27.837 -100.674 1.00 31.79 ? 312 VAL A O 1 ATOM 2278 C CB . VAL A 1 281 ? -5.544 -26.639 -97.657 1.00 23.11 ? 312 VAL A CB 1 ATOM 2279 C CG1 . VAL A 1 281 ? -4.744 -27.923 -97.772 1.00 26.86 ? 312 VAL A CG1 1 ATOM 2280 C CG2 . VAL A 1 281 ? -4.768 -25.619 -96.848 1.00 23.74 ? 312 VAL A CG2 1 ATOM 2281 N N . CYS A 1 282 ? -7.823 -27.277 -99.868 1.00 28.92 ? 313 CYS A N 1 ATOM 2282 C CA . CYS A 1 282 ? -8.548 -28.243 -100.689 1.00 26.60 ? 313 CYS A CA 1 ATOM 2283 C C . CYS A 1 282 ? -8.288 -28.036 -102.177 1.00 28.70 ? 313 CYS A C 1 ATOM 2284 O O . CYS A 1 282 ? -7.995 -28.987 -102.902 1.00 32.91 ? 313 CYS A O 1 ATOM 2285 C CB . CYS A 1 282 ? -10.051 -28.161 -100.417 1.00 33.25 ? 313 CYS A CB 1 ATOM 2286 S SG . CYS A 1 282 ? -10.575 -28.906 -98.859 1.00 35.16 ? 313 CYS A SG 1 ATOM 2287 N N . ASP A 1 283 ? -8.397 -26.791 -102.625 1.00 29.64 ? 314 ASP A N 1 ATOM 2288 C CA . ASP A 1 283 ? -8.174 -26.468 -104.029 1.00 28.05 ? 314 ASP A CA 1 ATOM 2289 C C . ASP A 1 283 ? -6.722 -26.709 -104.437 1.00 32.38 ? 314 ASP A C 1 ATOM 2290 O O . ASP A 1 283 ? -6.453 -27.187 -105.539 1.00 34.29 ? 314 ASP A O 1 ATOM 2291 C CB . ASP A 1 283 ? -8.574 -25.020 -104.310 1.00 30.96 ? 314 ASP A CB 1 ATOM 2292 C CG . ASP A 1 283 ? -10.079 -24.838 -104.376 1.00 42.57 ? 314 ASP A CG 1 ATOM 2293 O OD1 . ASP A 1 283 ? -10.752 -25.698 -104.981 1.00 46.70 ? 314 ASP A OD1 1 ATOM 2294 O OD2 . ASP A 1 283 ? -10.591 -23.843 -103.820 1.00 39.28 ? 314 ASP A OD2 1 ATOM 2295 N N . ILE A 1 284 ? -5.793 -26.385 -103.543 1.00 28.20 ? 315 ILE A N 1 ATOM 2296 C CA . ILE A 1 284 ? -4.374 -26.619 -103.796 1.00 23.83 ? 315 ILE A CA 1 ATOM 2297 C C . ILE A 1 284 ? -4.097 -28.115 -103.949 1.00 33.92 ? 315 ILE A C 1 ATOM 2298 O O . ILE A 1 284 ? -3.334 -28.529 -104.823 1.00 34.40 ? 315 ILE A O 1 ATOM 2299 C CB . ILE A 1 284 ? -3.496 -26.034 -102.670 1.00 27.62 ? 315 ILE A CB 1 ATOM 2300 C CG1 . ILE A 1 284 ? -3.565 -24.506 -102.685 1.00 26.26 ? 315 ILE A CG1 1 ATOM 2301 C CG2 . ILE A 1 284 ? -2.054 -26.498 -102.803 1.00 17.25 ? 315 ILE A CG2 1 ATOM 2302 C CD1 . ILE A 1 284 ? -2.699 -23.847 -101.630 1.00 29.38 ? 315 ILE A CD1 1 ATOM 2303 N N . LEU A 1 285 ? -4.733 -28.922 -103.107 1.00 31.34 ? 316 LEU A N 1 ATOM 2304 C CA . LEU A 1 285 ? -4.579 -30.372 -103.181 1.00 35.34 ? 316 LEU A CA 1 ATOM 2305 C C . LEU A 1 285 ? -5.239 -30.944 -104.433 1.00 37.38 ? 316 LEU A C 1 ATOM 2306 O O . LEU A 1 285 ? -4.695 -31.847 -105.066 1.00 36.48 ? 316 LEU A O 1 ATOM 2307 C CB . LEU A 1 285 ? -5.159 -31.039 -101.933 1.00 32.55 ? 316 LEU A CB 1 ATOM 2308 C CG . LEU A 1 285 ? -4.348 -30.865 -100.650 1.00 32.67 ? 316 LEU A CG 1 ATOM 2309 C CD1 . LEU A 1 285 ? -5.086 -31.452 -99.454 1.00 28.37 ? 316 LEU A CD1 1 ATOM 2310 C CD2 . LEU A 1 285 ? -2.975 -31.500 -100.808 1.00 23.39 ? 316 LEU A CD2 1 ATOM 2311 N N . LYS A 1 286 ? -6.410 -30.418 -104.783 1.00 38.64 ? 317 LYS A N 1 ATOM 2312 C CA . LYS A 1 286 ? -7.121 -30.862 -105.979 1.00 40.00 ? 317 LYS A CA 1 ATOM 2313 C C . LYS A 1 286 ? -6.301 -30.558 -107.228 1.00 43.10 ? 317 LYS A C 1 ATOM 2314 O O . LYS A 1 286 ? -6.333 -31.307 -108.205 1.00 37.99 ? 317 LYS A O 1 ATOM 2315 C CB . LYS A 1 286 ? -8.493 -30.196 -106.073 1.00 34.43 ? 317 LYS A CB 1 ATOM 2316 C CG . LYS A 1 286 ? -9.383 -30.783 -107.155 1.00 41.53 ? 317 LYS A CG 1 ATOM 2317 C CD . LYS A 1 286 ? -10.727 -30.075 -107.221 1.00 49.53 ? 317 LYS A CD 1 ATOM 2318 C CE . LYS A 1 286 ? -11.680 -30.805 -108.153 1.00 66.00 ? 317 LYS A CE 1 ATOM 2319 N NZ . LYS A 1 286 ? -12.015 -32.162 -107.638 1.00 55.49 ? 317 LYS A NZ 1 ATOM 2320 N N . GLN A 1 287 ? -5.572 -29.447 -107.182 1.00 42.13 ? 318 GLN A N 1 ATOM 2321 C CA . GLN A 1 287 ? -4.641 -29.071 -108.238 1.00 35.70 ? 318 GLN A CA 1 ATOM 2322 C C . GLN A 1 287 ? -3.563 -30.138 -108.422 1.00 37.35 ? 318 GLN A C 1 ATOM 2323 O O . GLN A 1 287 ? -3.255 -30.540 -109.543 1.00 30.95 ? 318 GLN A O 1 ATOM 2324 C CB . GLN A 1 287 ? -3.999 -27.720 -107.915 1.00 47.91 ? 318 GLN A CB 1 ATOM 2325 C CG . GLN A 1 287 ? -2.795 -27.361 -108.772 1.00 66.89 ? 318 GLN A CG 1 ATOM 2326 C CD . GLN A 1 287 ? -3.176 -26.601 -110.024 1.00 80.40 ? 318 GLN A CD 1 ATOM 2327 O OE1 . GLN A 1 287 ? -4.304 -26.703 -110.507 1.00 76.14 ? 318 GLN A OE1 1 ATOM 2328 N NE2 . GLN A 1 287 ? -2.237 -25.822 -110.551 1.00 85.22 ? 318 GLN A NE2 1 ATOM 2329 N N . GLU A 1 288 ? -2.998 -30.593 -107.307 1.00 45.44 ? 319 GLU A N 1 ATOM 2330 C CA . GLU A 1 288 ? -1.947 -31.605 -107.327 1.00 40.59 ? 319 GLU A CA 1 ATOM 2331 C C . GLU A 1 288 ? -2.504 -32.995 -107.615 1.00 40.06 ? 319 GLU A C 1 ATOM 2332 O O . GLU A 1 288 ? -1.855 -33.808 -108.271 1.00 41.50 ? 319 GLU A O 1 ATOM 2333 C CB . GLU A 1 288 ? -1.195 -31.617 -105.994 1.00 34.20 ? 319 GLU A CB 1 ATOM 2334 C CG . GLU A 1 288 ? -0.433 -30.340 -105.698 1.00 41.23 ? 319 GLU A CG 1 ATOM 2335 C CD . GLU A 1 288 ? 0.756 -30.154 -106.614 1.00 52.26 ? 319 GLU A CD 1 ATOM 2336 O OE1 . GLU A 1 288 ? 1.622 -31.054 -106.655 1.00 56.94 ? 319 GLU A OE1 1 ATOM 2337 O OE2 . GLU A 1 288 ? 0.822 -29.111 -107.298 1.00 60.97 ? 319 GLU A OE2 1 ATOM 2338 N N . HIS A 1 289 ? -3.706 -33.265 -107.116 1.00 32.08 ? 320 HIS A N 1 ATOM 2339 C CA . HIS A 1 289 ? -4.317 -34.579 -107.271 1.00 35.14 ? 320 HIS A CA 1 ATOM 2340 C C . HIS A 1 289 ? -5.711 -34.489 -107.881 1.00 36.63 ? 320 HIS A C 1 ATOM 2341 O O . HIS A 1 289 ? -6.708 -34.505 -107.161 1.00 36.41 ? 320 HIS A O 1 ATOM 2342 C CB . HIS A 1 289 ? -4.396 -35.296 -105.921 1.00 32.75 ? 320 HIS A CB 1 ATOM 2343 C CG . HIS A 1 289 ? -3.083 -35.401 -105.212 1.00 37.71 ? 320 HIS A CG 1 ATOM 2344 N ND1 . HIS A 1 289 ? -2.183 -36.416 -105.456 1.00 35.11 ? 320 HIS A ND1 1 ATOM 2345 C CD2 . HIS A 1 289 ? -2.520 -34.621 -104.259 1.00 39.27 ? 320 HIS A CD2 1 ATOM 2346 C CE1 . HIS A 1 289 ? -1.121 -36.254 -104.687 1.00 37.30 ? 320 HIS A CE1 1 ATOM 2347 N NE2 . HIS A 1 289 ? -1.300 -35.172 -103.951 1.00 40.25 ? 320 HIS A NE2 1 ATOM 2348 N N . PRO A 1 290 ? -5.787 -34.397 -109.215 1.00 42.72 ? 321 PRO A N 1 ATOM 2349 C CA . PRO A 1 290 ? -7.094 -34.405 -109.882 1.00 36.57 ? 321 PRO A CA 1 ATOM 2350 C C . PRO A 1 290 ? -7.776 -35.770 -109.794 1.00 36.85 ? 321 PRO A C 1 ATOM 2351 O O . PRO A 1 290 ? -8.958 -35.888 -110.116 1.00 39.87 ? 321 PRO A O 1 ATOM 2352 C CB . PRO A 1 290 ? -6.750 -34.050 -111.333 1.00 26.27 ? 321 PRO A CB 1 ATOM 2353 C CG . PRO A 1 290 ? -5.323 -34.453 -111.496 1.00 23.82 ? 321 PRO A CG 1 ATOM 2354 C CD . PRO A 1 290 ? -4.678 -34.202 -110.165 1.00 36.92 ? 321 PRO A CD 1 ATOM 2355 N N . GLU A 1 291 ? -7.036 -36.785 -109.354 1.00 37.88 ? 322 GLU A N 1 ATOM 2356 C CA . GLU A 1 291 ? -7.563 -38.144 -109.266 1.00 32.10 ? 322 GLU A CA 1 ATOM 2357 C C . GLU A 1 291 ? -8.166 -38.444 -107.895 1.00 29.54 ? 322 GLU A C 1 ATOM 2358 O O . GLU A 1 291 ? -8.803 -39.479 -107.706 1.00 41.10 ? 322 GLU A O 1 ATOM 2359 C CB . GLU A 1 291 ? -6.465 -39.165 -109.579 1.00 34.64 ? 322 GLU A CB 1 ATOM 2360 C CG . GLU A 1 291 ? -5.449 -39.371 -108.459 1.00 36.29 ? 322 GLU A CG 1 ATOM 2361 C CD . GLU A 1 291 ? -4.418 -38.260 -108.370 1.00 44.32 ? 322 GLU A CD 1 ATOM 2362 O OE1 . GLU A 1 291 ? -3.506 -38.363 -107.521 1.00 41.62 ? 322 GLU A OE1 1 ATOM 2363 O OE2 . GLU A 1 291 ? -4.512 -37.286 -109.148 1.00 42.15 ? 322 GLU A OE2 1 ATOM 2364 N N . TRP A 1 292 ? -7.962 -37.540 -106.941 1.00 38.97 ? 323 TRP A N 1 ATOM 2365 C CA . TRP A 1 292 ? -8.480 -37.730 -105.588 1.00 33.56 ? 323 TRP A CA 1 ATOM 2366 C C . TRP A 1 292 ? -9.972 -37.454 -105.493 1.00 31.65 ? 323 TRP A C 1 ATOM 2367 O O . TRP A 1 292 ? -10.513 -36.624 -106.223 1.00 41.26 ? 323 TRP A O 1 ATOM 2368 C CB . TRP A 1 292 ? -7.744 -36.831 -104.593 1.00 33.70 ? 323 TRP A CB 1 ATOM 2369 C CG . TRP A 1 292 ? -6.441 -37.380 -104.118 1.00 37.73 ? 323 TRP A CG 1 ATOM 2370 C CD1 . TRP A 1 292 ? -5.800 -38.492 -104.578 1.00 34.04 ? 323 TRP A CD1 1 ATOM 2371 C CD2 . TRP A 1 292 ? -5.617 -36.840 -103.082 1.00 36.11 ? 323 TRP A CD2 1 ATOM 2372 N NE1 . TRP A 1 292 ? -4.624 -38.677 -103.892 1.00 32.57 ? 323 TRP A NE1 1 ATOM 2373 C CE2 . TRP A 1 292 ? -4.489 -37.673 -102.966 1.00 34.05 ? 323 TRP A CE2 1 ATOM 2374 C CE3 . TRP A 1 292 ? -5.722 -35.728 -102.239 1.00 32.24 ? 323 TRP A CE3 1 ATOM 2375 C CZ2 . TRP A 1 292 ? -3.473 -37.434 -102.045 1.00 30.84 ? 323 TRP A CZ2 1 ATOM 2376 C CZ3 . TRP A 1 292 ? -4.715 -35.492 -101.325 1.00 33.46 ? 323 TRP A CZ3 1 ATOM 2377 C CH2 . TRP A 1 292 ? -3.605 -36.340 -101.235 1.00 29.51 ? 323 TRP A CH2 1 ATOM 2378 N N . GLY A 1 293 ? -10.627 -38.153 -104.574 1.00 27.97 ? 324 GLY A N 1 ATOM 2379 C CA . GLY A 1 293 ? -12.030 -37.922 -104.296 1.00 27.72 ? 324 GLY A CA 1 ATOM 2380 C C . GLY A 1 293 ? -12.220 -36.954 -103.144 1.00 35.05 ? 324 GLY A C 1 ATOM 2381 O O . GLY A 1 293 ? -11.251 -36.477 -102.552 1.00 32.25 ? 324 GLY A O 1 ATOM 2382 N N . ASP A 1 294 ? -13.480 -36.674 -102.826 1.00 35.06 ? 325 ASP A N 1 ATOM 2383 C CA . ASP A 1 294 ? -13.837 -35.731 -101.771 1.00 25.02 ? 325 ASP A CA 1 ATOM 2384 C C . ASP A 1 294 ? -13.274 -36.116 -100.405 1.00 32.48 ? 325 ASP A C 1 ATOM 2385 O O . ASP A 1 294 ? -12.771 -35.265 -99.673 1.00 37.33 ? 325 ASP A O 1 ATOM 2386 C CB . ASP A 1 294 ? -15.360 -35.606 -101.682 1.00 31.81 ? 325 ASP A CB 1 ATOM 2387 C CG . ASP A 1 294 ? -15.814 -34.859 -100.445 1.00 33.95 ? 325 ASP A CG 1 ATOM 2388 O OD1 . ASP A 1 294 ? -15.742 -33.615 -100.446 1.00 41.90 ? 325 ASP A OD1 1 ATOM 2389 O OD2 . ASP A 1 294 ? -16.254 -35.514 -99.477 1.00 38.55 ? 325 ASP A OD2 1 ATOM 2390 N N . GLU A 1 295 ? -13.358 -37.398 -100.066 1.00 36.57 ? 326 GLU A N 1 ATOM 2391 C CA . GLU A 1 295 ? -12.957 -37.864 -98.744 1.00 32.28 ? 326 GLU A CA 1 ATOM 2392 C C . GLU A 1 295 ? -11.469 -37.633 -98.478 1.00 34.97 ? 326 GLU A C 1 ATOM 2393 O O . GLU A 1 295 ? -11.102 -37.045 -97.461 1.00 32.95 ? 326 GLU A O 1 ATOM 2394 C CB . GLU A 1 295 ? -13.299 -39.347 -98.575 1.00 33.06 ? 326 GLU A CB 1 ATOM 2395 C CG . GLU A 1 295 ? -13.085 -39.886 -97.166 1.00 30.25 ? 326 GLU A CG 1 ATOM 2396 C CD . GLU A 1 295 ? -14.040 -39.282 -96.152 1.00 33.35 ? 326 GLU A CD 1 ATOM 2397 O OE1 . GLU A 1 295 ? -15.075 -38.719 -96.568 1.00 35.59 ? 326 GLU A OE1 1 ATOM 2398 O OE2 . GLU A 1 295 ? -13.755 -39.370 -94.938 1.00 30.04 ? 326 GLU A OE2 1 ATOM 2399 N N . GLN A 1 296 ? -10.615 -38.083 -99.392 1.00 32.29 ? 327 GLN A N 1 ATOM 2400 C CA . GLN A 1 296 ? -9.175 -37.936 -99.205 1.00 30.42 ? 327 GLN A CA 1 ATOM 2401 C C . GLN A 1 296 ? -8.759 -36.465 -99.220 1.00 36.63 ? 327 GLN A C 1 ATOM 2402 O O . GLN A 1 296 ? -7.803 -36.074 -98.550 1.00 37.28 ? 327 GLN A O 1 ATOM 2403 C CB . GLN A 1 296 ? -8.409 -38.719 -100.276 1.00 25.86 ? 327 GLN A CB 1 ATOM 2404 C CG . GLN A 1 296 ? -6.908 -38.785 -100.029 1.00 25.73 ? 327 GLN A CG 1 ATOM 2405 C CD . GLN A 1 296 ? -6.209 -39.815 -100.895 1.00 34.58 ? 327 GLN A CD 1 ATOM 2406 O OE1 . GLN A 1 296 ? -6.820 -40.437 -101.765 1.00 31.28 ? 327 GLN A OE1 1 ATOM 2407 N NE2 . GLN A 1 296 ? -4.918 -40.002 -100.656 1.00 33.63 ? 327 GLN A NE2 1 ATOM 2408 N N . LEU A 1 297 ? -9.485 -35.652 -99.981 1.00 35.21 ? 328 LEU A N 1 ATOM 2409 C CA . LEU A 1 297 ? -9.219 -34.219 -100.030 1.00 32.27 ? 328 LEU A CA 1 ATOM 2410 C C . LEU A 1 297 ? -9.522 -33.566 -98.688 1.00 34.49 ? 328 LEU A C 1 ATOM 2411 O O . LEU A 1 297 ? -8.761 -32.723 -98.211 1.00 32.49 ? 328 LEU A O 1 ATOM 2412 C CB . LEU A 1 297 ? -10.037 -33.553 -101.138 1.00 34.55 ? 328 LEU A CB 1 ATOM 2413 C CG . LEU A 1 297 ? -9.483 -33.702 -102.554 1.00 36.56 ? 328 LEU A CG 1 ATOM 2414 C CD1 . LEU A 1 297 ? -10.479 -33.184 -103.579 1.00 33.50 ? 328 LEU A CD1 1 ATOM 2415 C CD2 . LEU A 1 297 ? -8.155 -32.973 -102.674 1.00 31.39 ? 328 LEU A CD2 1 ATOM 2416 N N . PHE A 1 298 ? -10.634 -33.961 -98.078 1.00 32.78 ? 329 PHE A N 1 ATOM 2417 C CA . PHE A 1 298 ? -11.013 -33.431 -96.775 1.00 27.93 ? 329 PHE A CA 1 ATOM 2418 C C . PHE A 1 298 ? -10.032 -33.856 -95.690 1.00 34.86 ? 329 PHE A C 1 ATOM 2419 O O . PHE A 1 298 ? -9.563 -33.029 -94.910 1.00 35.34 ? 329 PHE A O 1 ATOM 2420 C CB . PHE A 1 298 ? -12.421 -33.887 -96.399 1.00 25.61 ? 329 PHE A CB 1 ATOM 2421 C CG . PHE A 1 298 ? -12.793 -33.594 -94.970 1.00 31.59 ? 329 PHE A CG 1 ATOM 2422 C CD1 . PHE A 1 298 ? -13.270 -32.346 -94.606 1.00 28.43 ? 329 PHE A CD1 1 ATOM 2423 C CD2 . PHE A 1 298 ? -12.675 -34.571 -93.991 1.00 31.76 ? 329 PHE A CD2 1 ATOM 2424 C CE1 . PHE A 1 298 ? -13.615 -32.074 -93.297 1.00 31.41 ? 329 PHE A CE1 1 ATOM 2425 C CE2 . PHE A 1 298 ? -13.017 -34.305 -92.679 1.00 33.24 ? 329 PHE A CE2 1 ATOM 2426 C CZ . PHE A 1 298 ? -13.488 -33.055 -92.330 1.00 35.17 ? 329 PHE A CZ 1 ATOM 2427 N N . GLN A 1 299 ? -9.735 -35.151 -95.644 1.00 35.87 ? 330 GLN A N 1 ATOM 2428 C CA . GLN A 1 299 ? -8.885 -35.710 -94.599 1.00 28.51 ? 330 GLN A CA 1 ATOM 2429 C C . GLN A 1 299 ? -7.468 -35.149 -94.651 1.00 29.02 ? 330 GLN A C 1 ATOM 2430 O O . GLN A 1 299 ? -6.907 -34.771 -93.620 1.00 30.61 ? 330 GLN A O 1 ATOM 2431 C CB . GLN A 1 299 ? -8.848 -37.238 -94.702 1.00 30.61 ? 330 GLN A CB 1 ATOM 2432 C CG . GLN A 1 299 ? -10.198 -37.921 -94.507 1.00 31.90 ? 330 GLN A CG 1 ATOM 2433 C CD . GLN A 1 299 ? -10.755 -37.748 -93.105 1.00 33.68 ? 330 GLN A CD 1 ATOM 2434 O OE1 . GLN A 1 299 ? -10.045 -37.343 -92.184 1.00 32.80 ? 330 GLN A OE1 1 ATOM 2435 N NE2 . GLN A 1 299 ? -12.035 -38.058 -92.938 1.00 25.39 ? 330 GLN A NE2 1 ATOM 2436 N N . THR A 1 300 ? -6.894 -35.096 -95.850 1.00 31.00 ? 331 THR A N 1 ATOM 2437 C CA . THR A 1 300 ? -5.537 -34.586 -96.026 1.00 30.74 ? 331 THR A CA 1 ATOM 2438 C C . THR A 1 300 ? -5.453 -33.110 -95.647 1.00 27.62 ? 331 THR A C 1 ATOM 2439 O O . THR A 1 300 ? -4.466 -32.666 -95.063 1.00 30.55 ? 331 THR A O 1 ATOM 2440 C CB . THR A 1 300 ? -5.050 -34.766 -97.475 1.00 27.74 ? 331 THR A CB 1 ATOM 2441 O OG1 . THR A 1 300 ? -5.287 -36.116 -97.894 1.00 28.21 ? 331 THR A OG1 1 ATOM 2442 C CG2 . THR A 1 300 ? -3.564 -34.458 -97.587 1.00 26.66 ? 331 THR A CG2 1 ATOM 2443 N N . SER A 1 301 ? -6.498 -32.357 -95.975 1.00 24.93 ? 332 SER A N 1 ATOM 2444 C CA . SER A 1 301 ? -6.558 -30.941 -95.632 1.00 24.13 ? 332 SER A CA 1 ATOM 2445 C C . SER A 1 301 ? -6.630 -30.750 -94.122 1.00 28.55 ? 332 SER A C 1 ATOM 2446 O O . SER A 1 301 ? -6.045 -29.811 -93.582 1.00 32.74 ? 332 SER A O 1 ATOM 2447 C CB . SER A 1 301 ? -7.757 -30.268 -96.302 1.00 25.17 ? 332 SER A CB 1 ATOM 2448 O OG . SER A 1 301 ? -7.612 -30.251 -97.710 1.00 35.51 ? 332 SER A OG 1 ATOM 2449 N N . ARG A 1 302 ? -7.349 -31.641 -93.446 1.00 25.79 ? 333 ARG A N 1 ATOM 2450 C CA . ARG A 1 302 ? -7.455 -31.578 -91.993 1.00 26.49 ? 333 ARG A CA 1 ATOM 2451 C C . ARG A 1 302 ? -6.097 -31.822 -91.340 1.00 30.70 ? 333 ARG A C 1 ATOM 2452 O O . ARG A 1 302 ? -5.746 -31.165 -90.362 1.00 29.42 ? 333 ARG A O 1 ATOM 2453 C CB . ARG A 1 302 ? -8.479 -32.588 -91.474 1.00 22.03 ? 333 ARG A CB 1 ATOM 2454 C CG . ARG A 1 302 ? -8.595 -32.603 -89.957 1.00 22.45 ? 333 ARG A CG 1 ATOM 2455 C CD . ARG A 1 302 ? -9.792 -33.409 -89.477 1.00 30.94 ? 333 ARG A CD 1 ATOM 2456 N NE . ARG A 1 302 ? -10.010 -33.246 -88.041 1.00 32.80 ? 333 ARG A NE 1 ATOM 2457 C CZ . ARG A 1 302 ? -11.089 -33.675 -87.393 1.00 25.87 ? 333 ARG A CZ 1 ATOM 2458 N NH1 . ARG A 1 302 ? -12.060 -34.296 -88.051 1.00 20.93 ? 333 ARG A NH1 1 ATOM 2459 N NH2 . ARG A 1 302 ? -11.202 -33.479 -86.086 1.00 28.42 ? 333 ARG A NH2 1 ATOM 2460 N N . LEU A 1 303 ? -5.336 -32.764 -91.887 1.00 24.94 ? 334 LEU A N 1 ATOM 2461 C CA . LEU A 1 303 ? -4.004 -33.056 -91.373 1.00 26.53 ? 334 LEU A CA 1 ATOM 2462 C C . LEU A 1 303 ? -3.076 -31.859 -91.555 1.00 29.35 ? 334 LEU A C 1 ATOM 2463 O O . LEU A 1 303 ? -2.266 -31.548 -90.680 1.00 30.34 ? 334 LEU A O 1 ATOM 2464 C CB . LEU A 1 303 ? -3.420 -34.292 -92.062 1.00 25.33 ? 334 LEU A CB 1 ATOM 2465 C CG . LEU A 1 303 ? -4.104 -35.619 -91.727 1.00 27.47 ? 334 LEU A CG 1 ATOM 2466 C CD1 . LEU A 1 303 ? -3.413 -36.776 -92.429 1.00 27.48 ? 334 LEU A CD1 1 ATOM 2467 C CD2 . LEU A 1 303 ? -4.123 -35.837 -90.224 1.00 22.39 ? 334 LEU A CD2 1 ATOM 2468 N N . ILE A 1 304 ? -3.210 -31.185 -92.693 1.00 29.24 ? 335 ILE A N 1 ATOM 2469 C CA . ILE A 1 304 ? -2.376 -30.029 -93.003 1.00 27.54 ? 335 ILE A CA 1 ATOM 2470 C C . ILE A 1 304 ? -2.698 -28.854 -92.079 1.00 29.88 ? 335 ILE A C 1 ATOM 2471 O O . ILE A 1 304 ? -1.795 -28.176 -91.585 1.00 31.36 ? 335 ILE A O 1 ATOM 2472 C CB . ILE A 1 304 ? -2.544 -29.602 -94.476 1.00 28.07 ? 335 ILE A CB 1 ATOM 2473 C CG1 . ILE A 1 304 ? -1.968 -30.676 -95.401 1.00 24.63 ? 335 ILE A CG1 1 ATOM 2474 C CG2 . ILE A 1 304 ? -1.870 -28.264 -94.737 1.00 28.13 ? 335 ILE A CG2 1 ATOM 2475 C CD1 . ILE A 1 304 ? -2.149 -30.377 -96.871 1.00 25.59 ? 335 ILE A CD1 1 ATOM 2476 N N . LEU A 1 305 ? -3.984 -28.624 -91.832 1.00 26.35 ? 336 LEU A N 1 ATOM 2477 C CA . LEU A 1 305 ? -4.399 -27.545 -90.942 1.00 26.35 ? 336 LEU A CA 1 ATOM 2478 C C . LEU A 1 305 ? -3.996 -27.824 -89.498 1.00 31.22 ? 336 LEU A C 1 ATOM 2479 O O . LEU A 1 305 ? -3.784 -26.897 -88.717 1.00 35.45 ? 336 LEU A O 1 ATOM 2480 C CB . LEU A 1 305 ? -5.908 -27.318 -91.032 1.00 24.08 ? 336 LEU A CB 1 ATOM 2481 C CG . LEU A 1 305 ? -6.356 -26.194 -91.969 1.00 28.02 ? 336 LEU A CG 1 ATOM 2482 C CD1 . LEU A 1 305 ? -5.974 -26.500 -93.408 1.00 21.72 ? 336 LEU A CD1 1 ATOM 2483 C CD2 . LEU A 1 305 ? -7.851 -25.956 -91.844 1.00 28.79 ? 336 LEU A CD2 1 ATOM 2484 N N . ILE A 1 306 ? -3.896 -29.101 -89.143 1.00 33.17 ? 337 ILE A N 1 ATOM 2485 C CA . ILE A 1 306 ? -3.402 -29.476 -87.824 1.00 26.06 ? 337 ILE A CA 1 ATOM 2486 C C . ILE A 1 306 ? -1.928 -29.101 -87.723 1.00 32.19 ? 337 ILE A C 1 ATOM 2487 O O . ILE A 1 306 ? -1.487 -28.527 -86.726 1.00 30.80 ? 337 ILE A O 1 ATOM 2488 C CB . ILE A 1 306 ? -3.593 -30.982 -87.543 1.00 27.68 ? 337 ILE A CB 1 ATOM 2489 C CG1 . ILE A 1 306 ? -5.072 -31.294 -87.302 1.00 28.49 ? 337 ILE A CG1 1 ATOM 2490 C CG2 . ILE A 1 306 ? -2.778 -31.412 -86.333 1.00 26.12 ? 337 ILE A CG2 1 ATOM 2491 C CD1 . ILE A 1 306 ? -5.353 -32.761 -87.068 1.00 27.10 ? 337 ILE A CD1 1 ATOM 2492 N N . GLY A 1 307 ? -1.175 -29.413 -88.774 1.00 29.54 ? 338 GLY A N 1 ATOM 2493 C CA . GLY A 1 307 ? 0.226 -29.041 -88.850 1.00 22.91 ? 338 GLY A CA 1 ATOM 2494 C C . GLY A 1 307 ? 0.425 -27.535 -88.823 1.00 33.74 ? 338 GLY A C 1 ATOM 2495 O O . GLY A 1 307 ? 1.299 -27.031 -88.116 1.00 34.10 ? 338 GLY A O 1 ATOM 2496 N N . GLU A 1 308 ? -0.386 -26.816 -89.596 1.00 30.47 ? 339 GLU A N 1 ATOM 2497 C CA . GLU A 1 308 ? -0.332 -25.357 -89.623 1.00 30.57 ? 339 GLU A CA 1 ATOM 2498 C C . GLU A 1 308 ? -0.555 -24.772 -88.235 1.00 34.54 ? 339 GLU A C 1 ATOM 2499 O O . GLU A 1 308 ? 0.145 -23.845 -87.822 1.00 32.73 ? 339 GLU A O 1 ATOM 2500 C CB . GLU A 1 308 ? -1.375 -24.788 -90.591 1.00 31.52 ? 339 GLU A CB 1 ATOM 2501 C CG . GLU A 1 308 ? -1.015 -24.908 -92.058 1.00 31.89 ? 339 GLU A CG 1 ATOM 2502 C CD . GLU A 1 308 ? -1.947 -24.104 -92.945 1.00 35.15 ? 339 GLU A CD 1 ATOM 2503 O OE1 . GLU A 1 308 ? -2.796 -24.713 -93.628 1.00 39.14 ? 339 GLU A OE1 1 ATOM 2504 O OE2 . GLU A 1 308 ? -1.833 -22.862 -92.959 1.00 35.11 ? 339 GLU A OE2 1 ATOM 2505 N N . THR A 1 309 ? -1.535 -25.323 -87.523 1.00 32.96 ? 340 THR A N 1 ATOM 2506 C CA . THR A 1 309 ? -1.899 -24.833 -86.200 1.00 28.10 ? 340 THR A CA 1 ATOM 2507 C C . THR A 1 309 ? -0.744 -24.963 -85.212 1.00 29.39 ? 340 THR A C 1 ATOM 2508 O O . THR A 1 309 ? -0.397 -24.005 -84.525 1.00 28.75 ? 340 THR A O 1 ATOM 2509 C CB . THR A 1 309 ? -3.123 -25.581 -85.645 1.00 25.68 ? 340 THR A CB 1 ATOM 2510 O OG1 . THR A 1 309 ? -4.213 -25.467 -86.568 1.00 29.31 ? 340 THR A OG1 1 ATOM 2511 C CG2 . THR A 1 309 ? -3.537 -25.000 -84.304 1.00 22.62 ? 340 THR A CG2 1 ATOM 2512 N N . ILE A 1 310 ? -0.149 -26.149 -85.149 1.00 28.32 ? 341 ILE A N 1 ATOM 2513 C CA . ILE A 1 310 ? 0.963 -26.395 -84.240 1.00 25.94 ? 341 ILE A CA 1 ATOM 2514 C C . ILE A 1 310 ? 2.161 -25.525 -84.617 1.00 32.56 ? 341 ILE A C 1 ATOM 2515 O O . ILE A 1 310 ? 2.861 -25.003 -83.747 1.00 32.81 ? 341 ILE A O 1 ATOM 2516 C CB . ILE A 1 310 ? 1.376 -27.879 -84.244 1.00 26.12 ? 341 ILE A CB 1 ATOM 2517 C CG1 . ILE A 1 310 ? 0.176 -28.765 -83.907 1.00 25.04 ? 341 ILE A CG1 1 ATOM 2518 C CG2 . ILE A 1 310 ? 2.518 -28.124 -83.270 1.00 22.84 ? 341 ILE A CG2 1 ATOM 2519 C CD1 . ILE A 1 310 ? 0.485 -30.245 -83.954 1.00 25.53 ? 341 ILE A CD1 1 ATOM 2520 N N . LYS A 1 311 ? 2.384 -25.372 -85.920 1.00 27.37 ? 342 LYS A N 1 ATOM 2521 C CA . LYS A 1 311 ? 3.444 -24.510 -86.435 1.00 26.15 ? 342 LYS A CA 1 ATOM 2522 C C . LYS A 1 311 ? 3.260 -23.066 -85.974 1.00 29.23 ? 342 LYS A C 1 ATOM 2523 O O . LYS A 1 311 ? 4.204 -22.428 -85.505 1.00 29.37 ? 342 LYS A O 1 ATOM 2524 C CB . LYS A 1 311 ? 3.477 -24.573 -87.961 1.00 25.81 ? 342 LYS A CB 1 ATOM 2525 C CG . LYS A 1 311 ? 4.346 -23.520 -88.622 1.00 25.24 ? 342 LYS A CG 1 ATOM 2526 C CD . LYS A 1 311 ? 5.822 -23.826 -88.473 1.00 29.44 ? 342 LYS A CD 1 ATOM 2527 C CE . LYS A 1 311 ? 6.647 -22.969 -89.418 1.00 30.26 ? 342 LYS A CE 1 ATOM 2528 N NZ . LYS A 1 311 ? 8.085 -23.347 -89.413 1.00 29.10 ? 342 LYS A NZ 1 ATOM 2529 N N . ILE A 1 312 ? 2.037 -22.563 -86.110 1.00 26.74 ? 343 ILE A N 1 ATOM 2530 C CA . ILE A 1 312 ? 1.714 -21.194 -85.728 1.00 23.41 ? 343 ILE A CA 1 ATOM 2531 C C . ILE A 1 312 ? 1.772 -20.993 -84.214 1.00 27.60 ? 343 ILE A C 1 ATOM 2532 O O . ILE A 1 312 ? 2.321 -20.000 -83.734 1.00 32.39 ? 343 ILE A O 1 ATOM 2533 C CB . ILE A 1 312 ? 0.315 -20.792 -86.245 1.00 23.84 ? 343 ILE A CB 1 ATOM 2534 C CG1 . ILE A 1 312 ? 0.329 -20.674 -87.770 1.00 22.37 ? 343 ILE A CG1 1 ATOM 2535 C CG2 . ILE A 1 312 ? -0.136 -19.483 -85.621 1.00 21.67 ? 343 ILE A CG2 1 ATOM 2536 C CD1 . ILE A 1 312 ? -1.031 -20.427 -88.379 1.00 20.71 ? 343 ILE A CD1 1 ATOM 2537 N N . VAL A 1 313 ? 1.218 -21.942 -83.465 1.00 26.80 ? 344 VAL A N 1 ATOM 2538 C CA . VAL A 1 313 ? 1.185 -21.842 -82.008 1.00 31.53 ? 344 VAL A CA 1 ATOM 2539 C C . VAL A 1 313 ? 2.595 -21.796 -81.413 1.00 29.28 ? 344 VAL A C 1 ATOM 2540 O O . VAL A 1 313 ? 2.853 -21.061 -80.462 1.00 30.91 ? 344 VAL A O 1 ATOM 2541 C CB . VAL A 1 313 ? 0.389 -23.015 -81.382 1.00 30.08 ? 344 VAL A CB 1 ATOM 2542 C CG1 . VAL A 1 313 ? 0.630 -23.095 -79.884 1.00 20.35 ? 344 VAL A CG1 1 ATOM 2543 C CG2 . VAL A 1 313 ? -1.100 -22.863 -81.676 1.00 24.76 ? 344 VAL A CG2 1 ATOM 2544 N N . ILE A 1 314 ? 3.516 -22.557 -81.992 1.00 30.02 ? 345 ILE A N 1 ATOM 2545 C CA . ILE A 1 314 ? 4.881 -22.596 -81.478 1.00 30.25 ? 345 ILE A CA 1 ATOM 2546 C C . ILE A 1 314 ? 5.720 -21.396 -81.931 1.00 31.78 ? 345 ILE A C 1 ATOM 2547 O O . ILE A 1 314 ? 6.341 -20.724 -81.108 1.00 33.83 ? 345 ILE A O 1 ATOM 2548 C CB . ILE A 1 314 ? 5.594 -23.896 -81.892 1.00 25.52 ? 345 ILE A CB 1 ATOM 2549 C CG1 . ILE A 1 314 ? 5.009 -25.086 -81.125 1.00 26.43 ? 345 ILE A CG1 1 ATOM 2550 C CG2 . ILE A 1 314 ? 7.085 -23.791 -81.630 1.00 19.68 ? 345 ILE A CG2 1 ATOM 2551 C CD1 . ILE A 1 314 ? 5.715 -26.401 -81.391 1.00 22.44 ? 345 ILE A CD1 1 ATOM 2552 N N . GLU A 1 315 ? 5.725 -21.116 -83.231 1.00 29.07 ? 346 GLU A N 1 ATOM 2553 C CA . GLU A 1 315 ? 6.649 -20.125 -83.779 1.00 27.35 ? 346 GLU A CA 1 ATOM 2554 C C . GLU A 1 315 ? 6.107 -18.694 -83.797 1.00 32.24 ? 346 GLU A C 1 ATOM 2555 O O . GLU A 1 315 ? 6.842 -17.759 -84.113 1.00 31.02 ? 346 GLU A O 1 ATOM 2556 C CB . GLU A 1 315 ? 7.069 -20.536 -85.191 1.00 24.66 ? 346 GLU A CB 1 ATOM 2557 C CG . GLU A 1 315 ? 7.860 -21.837 -85.234 1.00 29.92 ? 346 GLU A CG 1 ATOM 2558 C CD . GLU A 1 315 ? 8.529 -22.080 -86.574 1.00 35.98 ? 346 GLU A CD 1 ATOM 2559 O OE1 . GLU A 1 315 ? 8.559 -21.150 -87.407 1.00 36.06 ? 346 GLU A OE1 1 ATOM 2560 O OE2 . GLU A 1 315 ? 9.027 -23.203 -86.794 1.00 37.79 ? 346 GLU A OE2 1 ATOM 2561 N N . ASP A 1 316 ? 4.836 -18.516 -83.451 1.00 31.61 ? 347 ASP A N 1 ATOM 2562 C CA . ASP A 1 316 ? 4.250 -17.178 -83.393 1.00 26.32 ? 347 ASP A CA 1 ATOM 2563 C C . ASP A 1 316 ? 3.600 -16.908 -82.040 1.00 30.48 ? 347 ASP A C 1 ATOM 2564 O O . ASP A 1 316 ? 3.958 -15.957 -81.347 1.00 34.95 ? 347 ASP A O 1 ATOM 2565 C CB . ASP A 1 316 ? 3.220 -16.988 -84.509 1.00 27.30 ? 347 ASP A CB 1 ATOM 2566 C CG . ASP A 1 316 ? 3.855 -16.898 -85.884 1.00 29.67 ? 347 ASP A CG 1 ATOM 2567 O OD1 . ASP A 1 316 ? 4.956 -16.319 -85.998 1.00 35.02 ? 347 ASP A OD1 1 ATOM 2568 O OD2 . ASP A 1 316 ? 3.251 -17.405 -86.852 1.00 33.12 ? 347 ASP A OD2 1 ATOM 2569 N N . TYR A 1 317 ? 2.643 -17.755 -81.674 1.00 26.35 ? 348 TYR A N 1 ATOM 2570 C CA . TYR A 1 317 ? 1.894 -17.605 -80.428 1.00 24.60 ? 348 TYR A CA 1 ATOM 2571 C C . TYR A 1 317 ? 2.784 -17.736 -79.193 1.00 30.82 ? 348 TYR A C 1 ATOM 2572 O O . TYR A 1 317 ? 2.906 -16.797 -78.408 1.00 37.01 ? 348 TYR A O 1 ATOM 2573 C CB . TYR A 1 317 ? 0.765 -18.635 -80.376 1.00 24.71 ? 348 TYR A CB 1 ATOM 2574 C CG . TYR A 1 317 ? -0.075 -18.617 -79.119 1.00 27.77 ? 348 TYR A CG 1 ATOM 2575 C CD1 . TYR A 1 317 ? -1.161 -17.760 -78.998 1.00 33.61 ? 348 TYR A CD1 1 ATOM 2576 C CD2 . TYR A 1 317 ? 0.198 -19.481 -78.067 1.00 27.15 ? 348 TYR A CD2 1 ATOM 2577 C CE1 . TYR A 1 317 ? -1.943 -17.752 -77.854 1.00 35.78 ? 348 TYR A CE1 1 ATOM 2578 C CE2 . TYR A 1 317 ? -0.578 -19.479 -76.920 1.00 30.51 ? 348 TYR A CE2 1 ATOM 2579 C CZ . TYR A 1 317 ? -1.646 -18.614 -76.820 1.00 34.10 ? 348 TYR A CZ 1 ATOM 2580 O OH . TYR A 1 317 ? -2.418 -18.610 -75.681 1.00 40.51 ? 348 TYR A OH 1 ATOM 2581 N N . VAL A 1 318 ? 3.396 -18.904 -79.021 1.00 29.71 ? 349 VAL A N 1 ATOM 2582 C CA . VAL A 1 318 ? 4.281 -19.146 -77.885 1.00 34.13 ? 349 VAL A CA 1 ATOM 2583 C C . VAL A 1 318 ? 5.537 -18.278 -77.976 1.00 36.74 ? 349 VAL A C 1 ATOM 2584 O O . VAL A 1 318 ? 6.034 -17.785 -76.961 1.00 35.57 ? 349 VAL A O 1 ATOM 2585 C CB . VAL A 1 318 ? 4.671 -20.642 -77.788 1.00 33.01 ? 349 VAL A CB 1 ATOM 2586 C CG1 . VAL A 1 318 ? 5.856 -20.848 -76.855 1.00 22.29 ? 349 VAL A CG1 1 ATOM 2587 C CG2 . VAL A 1 318 ? 3.479 -21.466 -77.322 1.00 25.22 ? 349 VAL A CG2 1 ATOM 2588 N N . GLN A 1 319 ? 6.034 -18.077 -79.195 1.00 32.74 ? 350 GLN A N 1 ATOM 2589 C CA . GLN A 1 319 ? 7.203 -17.231 -79.421 1.00 29.58 ? 350 GLN A CA 1 ATOM 2590 C C . GLN A 1 319 ? 6.998 -15.834 -78.836 1.00 32.09 ? 350 GLN A C 1 ATOM 2591 O O . GLN A 1 319 ? 7.849 -15.330 -78.103 1.00 33.27 ? 350 GLN A O 1 ATOM 2592 C CB . GLN A 1 319 ? 7.515 -17.133 -80.916 1.00 28.93 ? 350 GLN A CB 1 ATOM 2593 C CG . GLN A 1 319 ? 8.703 -16.244 -81.248 1.00 25.37 ? 350 GLN A CG 1 ATOM 2594 C CD . GLN A 1 319 ? 10.028 -16.857 -80.839 1.00 33.29 ? 350 GLN A CD 1 ATOM 2595 O OE1 . GLN A 1 319 ? 10.478 -17.841 -81.427 1.00 34.79 ? 350 GLN A OE1 1 ATOM 2596 N NE2 . GLN A 1 319 ? 10.661 -16.278 -79.825 1.00 28.04 ? 350 GLN A NE2 1 ATOM 2597 N N . HIS A 1 320 ? 5.863 -15.219 -79.155 1.00 32.33 ? 351 HIS A N 1 ATOM 2598 C CA . HIS A 1 320 ? 5.526 -13.908 -78.612 1.00 32.15 ? 351 HIS A CA 1 ATOM 2599 C C . HIS A 1 320 ? 5.324 -13.958 -77.103 1.00 33.72 ? 351 HIS A C 1 ATOM 2600 O O . HIS A 1 320 ? 5.837 -13.116 -76.368 1.00 39.84 ? 351 HIS A O 1 ATOM 2601 C CB . HIS A 1 320 ? 4.264 -13.352 -79.274 1.00 31.66 ? 351 HIS A CB 1 ATOM 2602 C CG . HIS A 1 320 ? 3.595 -12.275 -78.477 1.00 30.24 ? 351 HIS A CG 1 ATOM 2603 N ND1 . HIS A 1 320 ? 4.058 -10.977 -78.443 1.00 28.36 ? 351 HIS A ND1 1 ATOM 2604 C CD2 . HIS A 1 320 ? 2.511 -12.309 -77.666 1.00 27.48 ? 351 HIS A CD2 1 ATOM 2605 C CE1 . HIS A 1 320 ? 3.281 -10.256 -77.654 1.00 31.91 ? 351 HIS A CE1 1 ATOM 2606 N NE2 . HIS A 1 320 ? 2.336 -11.040 -77.169 1.00 29.40 ? 351 HIS A NE2 1 ATOM 2607 N N . LEU A 1 321 ? 4.568 -14.951 -76.652 1.00 32.97 ? 352 LEU A N 1 ATOM 2608 C CA . LEU A 1 321 ? 4.215 -15.080 -75.246 1.00 28.28 ? 352 LEU A CA 1 ATOM 2609 C C . LEU A 1 321 ? 5.446 -15.315 -74.370 1.00 33.91 ? 352 LEU A C 1 ATOM 2610 O O . LEU A 1 321 ? 5.514 -14.833 -73.239 1.00 36.13 ? 352 LEU A O 1 ATOM 2611 C CB . LEU A 1 321 ? 3.207 -16.217 -75.068 1.00 28.79 ? 352 LEU A CB 1 ATOM 2612 C CG . LEU A 1 321 ? 2.454 -16.298 -73.741 1.00 36.67 ? 352 LEU A CG 1 ATOM 2613 C CD1 . LEU A 1 321 ? 1.823 -14.956 -73.409 1.00 31.12 ? 352 LEU A CD1 1 ATOM 2614 C CD2 . LEU A 1 321 ? 1.396 -17.391 -73.804 1.00 33.65 ? 352 LEU A CD2 1 ATOM 2615 N N . SER A 1 322 ? 6.421 -16.046 -74.902 1.00 27.80 ? 353 SER A N 1 ATOM 2616 C CA . SER A 1 322 ? 7.636 -16.361 -74.157 1.00 32.18 ? 353 SER A CA 1 ATOM 2617 C C . SER A 1 322 ? 8.513 -15.130 -73.969 1.00 37.95 ? 353 SER A C 1 ATOM 2618 O O . SER A 1 322 ? 9.143 -14.955 -72.927 1.00 37.02 ? 353 SER A O 1 ATOM 2619 C CB . SER A 1 322 ? 8.436 -17.452 -74.867 1.00 35.80 ? 353 SER A CB 1 ATOM 2620 O OG . SER A 1 322 ? 9.092 -16.930 -76.010 1.00 30.57 ? 353 SER A OG 1 ATOM 2621 N N . GLY A 1 323 ? 8.556 -14.282 -74.990 1.00 39.50 ? 354 GLY A N 1 ATOM 2622 C CA . GLY A 1 323 ? 9.383 -13.092 -74.950 1.00 32.10 ? 354 GLY A CA 1 ATOM 2623 C C . GLY A 1 323 ? 10.848 -13.417 -75.156 1.00 31.20 ? 354 GLY A C 1 ATOM 2624 O O . GLY A 1 323 ? 11.714 -12.573 -74.936 1.00 39.85 ? 354 GLY A O 1 ATOM 2625 N N . TYR A 1 324 ? 11.127 -14.644 -75.584 1.00 36.74 ? 355 TYR A N 1 ATOM 2626 C CA . TYR A 1 324 ? 12.503 -15.080 -75.797 1.00 37.35 ? 355 TYR A CA 1 ATOM 2627 C C . TYR A 1 324 ? 13.065 -14.479 -77.080 1.00 38.68 ? 355 TYR A C 1 ATOM 2628 O O . TYR A 1 324 ? 12.331 -14.246 -78.041 1.00 41.45 ? 355 TYR A O 1 ATOM 2629 C CB . TYR A 1 324 ? 12.598 -16.610 -75.861 1.00 32.68 ? 355 TYR A CB 1 ATOM 2630 C CG . TYR A 1 324 ? 12.114 -17.343 -74.622 1.00 40.95 ? 355 TYR A CG 1 ATOM 2631 C CD1 . TYR A 1 324 ? 11.899 -16.672 -73.424 1.00 38.13 ? 355 TYR A CD1 1 ATOM 2632 C CD2 . TYR A 1 324 ? 11.879 -18.712 -74.654 1.00 34.95 ? 355 TYR A CD2 1 ATOM 2633 C CE1 . TYR A 1 324 ? 11.456 -17.342 -72.298 1.00 40.08 ? 355 TYR A CE1 1 ATOM 2634 C CE2 . TYR A 1 324 ? 11.440 -19.388 -73.533 1.00 35.00 ? 355 TYR A CE2 1 ATOM 2635 C CZ . TYR A 1 324 ? 11.229 -18.702 -72.359 1.00 41.65 ? 355 TYR A CZ 1 ATOM 2636 O OH . TYR A 1 324 ? 10.789 -19.381 -71.244 1.00 40.33 ? 355 TYR A OH 1 ATOM 2637 N N . HIS A 1 325 ? 14.370 -14.227 -77.090 1.00 37.67 ? 356 HIS A N 1 ATOM 2638 C CA . HIS A 1 325 ? 15.042 -13.779 -78.302 1.00 33.19 ? 356 HIS A CA 1 ATOM 2639 C C . HIS A 1 325 ? 15.462 -14.987 -79.123 1.00 39.49 ? 356 HIS A C 1 ATOM 2640 O O . HIS A 1 325 ? 15.747 -14.875 -80.315 1.00 41.14 ? 356 HIS A O 1 ATOM 2641 C CB . HIS A 1 325 ? 16.250 -12.906 -77.966 1.00 38.37 ? 356 HIS A CB 1 ATOM 2642 C CG . HIS A 1 325 ? 15.886 -11.603 -77.327 1.00 46.99 ? 356 HIS A CG 1 ATOM 2643 N ND1 . HIS A 1 325 ? 14.940 -10.753 -77.858 1.00 40.65 ? 356 HIS A ND1 1 ATOM 2644 C CD2 . HIS A 1 325 ? 16.338 -11.005 -76.199 1.00 44.90 ? 356 HIS A CD2 1 ATOM 2645 C CE1 . HIS A 1 325 ? 14.824 -9.688 -77.086 1.00 46.92 ? 356 HIS A CE1 1 ATOM 2646 N NE2 . HIS A 1 325 ? 15.663 -9.816 -76.072 1.00 46.12 ? 356 HIS A NE2 1 ATOM 2647 N N . PHE A 1 326 ? 15.498 -16.144 -78.470 1.00 37.29 ? 357 PHE A N 1 ATOM 2648 C CA . PHE A 1 326 ? 15.744 -17.402 -79.159 1.00 33.38 ? 357 PHE A CA 1 ATOM 2649 C C . PHE A 1 326 ? 14.566 -17.728 -80.070 1.00 36.27 ? 357 PHE A C 1 ATOM 2650 O O . PHE A 1 326 ? 13.409 -17.695 -79.645 1.00 43.45 ? 357 PHE A O 1 ATOM 2651 C CB . PHE A 1 326 ? 15.980 -18.536 -78.158 1.00 34.40 ? 357 PHE A CB 1 ATOM 2652 C CG . PHE A 1 326 ? 16.051 -19.898 -78.789 1.00 34.09 ? 357 PHE A CG 1 ATOM 2653 C CD1 . PHE A 1 326 ? 17.083 -20.223 -79.655 1.00 33.21 ? 357 PHE A CD1 1 ATOM 2654 C CD2 . PHE A 1 326 ? 15.089 -20.856 -78.511 1.00 29.46 ? 357 PHE A CD2 1 ATOM 2655 C CE1 . PHE A 1 326 ? 17.151 -21.474 -80.237 1.00 27.60 ? 357 PHE A CE1 1 ATOM 2656 C CE2 . PHE A 1 326 ? 15.152 -22.111 -79.090 1.00 34.57 ? 357 PHE A CE2 1 ATOM 2657 C CZ . PHE A 1 326 ? 16.184 -22.420 -79.955 1.00 32.82 ? 357 PHE A CZ 1 ATOM 2658 N N . LYS A 1 327 ? 14.864 -18.032 -81.328 1.00 37.36 ? 358 LYS A N 1 ATOM 2659 C CA . LYS A 1 327 ? 13.826 -18.310 -82.310 1.00 38.79 ? 358 LYS A CA 1 ATOM 2660 C C . LYS A 1 327 ? 13.358 -19.760 -82.206 1.00 36.13 ? 358 LYS A C 1 ATOM 2661 O O . LYS A 1 327 ? 14.053 -20.679 -82.642 1.00 32.67 ? 358 LYS A O 1 ATOM 2662 C CB . LYS A 1 327 ? 14.341 -18.003 -83.718 1.00 39.00 ? 358 LYS A CB 1 ATOM 2663 C CG . LYS A 1 327 ? 13.306 -18.132 -84.819 1.00 42.38 ? 358 LYS A CG 1 ATOM 2664 C CD . LYS A 1 327 ? 13.847 -17.588 -86.132 1.00 59.13 ? 358 LYS A CD 1 ATOM 2665 C CE . LYS A 1 327 ? 12.912 -17.888 -87.291 1.00 59.13 ? 358 LYS A CE 1 ATOM 2666 N NZ . LYS A 1 327 ? 11.548 -17.330 -87.073 1.00 72.66 ? 358 LYS A NZ 1 ATOM 2667 N N . LEU A 1 328 ? 12.178 -19.955 -81.622 1.00 33.21 ? 359 LEU A N 1 ATOM 2668 C CA . LEU A 1 328 ? 11.621 -21.290 -81.428 1.00 28.26 ? 359 LEU A CA 1 ATOM 2669 C C . LEU A 1 328 ? 11.369 -21.977 -82.763 1.00 32.50 ? 359 LEU A C 1 ATOM 2670 O O . LEU A 1 328 ? 11.283 -21.325 -83.805 1.00 35.86 ? 359 LEU A O 1 ATOM 2671 C CB . LEU A 1 328 ? 10.325 -21.223 -80.620 1.00 30.86 ? 359 LEU A CB 1 ATOM 2672 C CG . LEU A 1 328 ? 10.443 -20.667 -79.199 1.00 33.43 ? 359 LEU A CG 1 ATOM 2673 C CD1 . LEU A 1 328 ? 9.078 -20.600 -78.537 1.00 23.06 ? 359 LEU A CD1 1 ATOM 2674 C CD2 . LEU A 1 328 ? 11.404 -21.505 -78.369 1.00 31.45 ? 359 LEU A CD2 1 ATOM 2675 N N . LYS A 1 329 ? 11.244 -23.297 -82.727 1.00 33.66 ? 360 LYS A N 1 ATOM 2676 C CA . LYS A 1 329 ? 11.169 -24.078 -83.953 1.00 31.67 ? 360 LYS A CA 1 ATOM 2677 C C . LYS A 1 329 ? 10.201 -25.249 -83.833 1.00 34.19 ? 360 LYS A C 1 ATOM 2678 O O . LYS A 1 329 ? 10.279 -26.041 -82.893 1.00 32.58 ? 360 LYS A O 1 ATOM 2679 C CB . LYS A 1 329 ? 12.562 -24.590 -84.327 1.00 28.92 ? 360 LYS A CB 1 ATOM 2680 C CG . LYS A 1 329 ? 12.652 -25.239 -85.693 1.00 35.76 ? 360 LYS A CG 1 ATOM 2681 C CD . LYS A 1 329 ? 14.058 -25.753 -85.952 1.00 39.14 ? 360 LYS A CD 1 ATOM 2682 C CE . LYS A 1 329 ? 14.190 -26.325 -87.353 1.00 40.63 ? 360 LYS A CE 1 ATOM 2683 N NZ . LYS A 1 329 ? 15.534 -26.926 -87.574 1.00 50.00 ? 360 LYS A NZ 1 ATOM 2684 N N . PHE A 1 330 ? 9.280 -25.352 -84.785 1.00 35.35 ? 361 PHE A N 1 ATOM 2685 C CA . PHE A 1 330 ? 8.438 -26.534 -84.880 1.00 28.41 ? 361 PHE A CA 1 ATOM 2686 C C . PHE A 1 330 ? 9.099 -27.538 -85.810 1.00 34.08 ? 361 PHE A C 1 ATOM 2687 O O . PHE A 1 330 ? 9.021 -27.418 -87.033 1.00 36.00 ? 361 PHE A O 1 ATOM 2688 C CB . PHE A 1 330 ? 7.033 -26.189 -85.376 1.00 26.89 ? 361 PHE A CB 1 ATOM 2689 C CG . PHE A 1 330 ? 6.190 -27.395 -85.680 1.00 29.96 ? 361 PHE A CG 1 ATOM 2690 C CD1 . PHE A 1 330 ? 5.999 -28.380 -84.724 1.00 29.70 ? 361 PHE A CD1 1 ATOM 2691 C CD2 . PHE A 1 330 ? 5.589 -27.546 -86.920 1.00 28.74 ? 361 PHE A CD2 1 ATOM 2692 C CE1 . PHE A 1 330 ? 5.229 -29.495 -85.000 1.00 32.36 ? 361 PHE A CE1 1 ATOM 2693 C CE2 . PHE A 1 330 ? 4.815 -28.658 -87.199 1.00 29.74 ? 361 PHE A CE2 1 ATOM 2694 C CZ . PHE A 1 330 ? 4.634 -29.633 -86.238 1.00 28.59 ? 361 PHE A CZ 1 ATOM 2695 N N . ASP A 1 331 ? 9.766 -28.521 -85.218 1.00 33.16 ? 362 ASP A N 1 ATOM 2696 C CA . ASP A 1 331 ? 10.446 -29.554 -85.984 1.00 34.73 ? 362 ASP A CA 1 ATOM 2697 C C . ASP A 1 331 ? 10.333 -30.893 -85.262 1.00 34.62 ? 362 ASP A C 1 ATOM 2698 O O . ASP A 1 331 ? 11.101 -31.172 -84.341 1.00 42.46 ? 362 ASP A O 1 ATOM 2699 C CB . ASP A 1 331 ? 11.913 -29.176 -86.205 1.00 37.32 ? 362 ASP A CB 1 ATOM 2700 C CG . ASP A 1 331 ? 12.631 -30.133 -87.134 1.00 50.52 ? 362 ASP A CG 1 ATOM 2701 O OD1 . ASP A 1 331 ? 11.948 -30.876 -87.872 1.00 49.93 ? 362 ASP A OD1 1 ATOM 2702 O OD2 . ASP A 1 331 ? 13.882 -30.136 -87.131 1.00 47.78 ? 362 ASP A OD2 1 ATOM 2703 N N . PRO A 1 332 ? 9.358 -31.720 -85.672 1.00 32.27 ? 363 PRO A N 1 ATOM 2704 C CA . PRO A 1 332 ? 9.128 -33.051 -85.095 1.00 33.66 ? 363 PRO A CA 1 ATOM 2705 C C . PRO A 1 332 ? 10.362 -33.948 -85.166 1.00 33.85 ? 363 PRO A C 1 ATOM 2706 O O . PRO A 1 332 ? 10.501 -34.878 -84.371 1.00 36.95 ? 363 PRO A O 1 ATOM 2707 C CB . PRO A 1 332 ? 7.999 -33.615 -85.961 1.00 24.29 ? 363 PRO A CB 1 ATOM 2708 C CG . PRO A 1 332 ? 7.275 -32.412 -86.454 1.00 30.35 ? 363 PRO A CG 1 ATOM 2709 C CD . PRO A 1 332 ? 8.333 -31.368 -86.669 1.00 33.63 ? 363 PRO A CD 1 ATOM 2710 N N . GLU A 1 333 ? 11.250 -33.655 -86.110 1.00 36.43 ? 364 GLU A N 1 ATOM 2711 C CA . GLU A 1 333 ? 12.463 -34.439 -86.313 1.00 40.87 ? 364 GLU A CA 1 ATOM 2712 C C . GLU A 1 333 ? 13.381 -34.387 -85.096 1.00 38.40 ? 364 GLU A C 1 ATOM 2713 O O . GLU A 1 333 ? 14.169 -35.301 -84.864 1.00 40.43 ? 364 GLU A O 1 ATOM 2714 C CB . GLU A 1 333 ? 13.206 -33.940 -87.553 1.00 43.07 ? 364 GLU A CB 1 ATOM 2715 C CG . GLU A 1 333 ? 14.051 -34.990 -88.243 1.00 53.69 ? 364 GLU A CG 1 ATOM 2716 C CD . GLU A 1 333 ? 13.740 -35.089 -89.722 1.00 85.41 ? 364 GLU A CD 1 ATOM 2717 O OE1 . GLU A 1 333 ? 12.731 -34.492 -90.157 1.00 67.01 ? 364 GLU A OE1 1 ATOM 2718 O OE2 . GLU A 1 333 ? 14.502 -35.759 -90.451 1.00 91.05 ? 364 GLU A OE2 1 ATOM 2719 N N . LEU A 1 334 ? 13.266 -33.314 -84.319 1.00 32.84 ? 365 LEU A N 1 ATOM 2720 C CA . LEU A 1 334 ? 14.110 -33.101 -83.147 1.00 34.05 ? 365 LEU A CA 1 ATOM 2721 C C . LEU A 1 334 ? 13.927 -34.174 -82.073 1.00 37.33 ? 365 LEU A C 1 ATOM 2722 O O . LEU A 1 334 ? 14.817 -34.395 -81.253 1.00 39.59 ? 365 LEU A O 1 ATOM 2723 C CB . LEU A 1 334 ? 13.827 -31.724 -82.541 1.00 36.79 ? 365 LEU A CB 1 ATOM 2724 C CG . LEU A 1 334 ? 14.161 -30.496 -83.388 1.00 31.53 ? 365 LEU A CG 1 ATOM 2725 C CD1 . LEU A 1 334 ? 13.695 -29.232 -82.688 1.00 28.00 ? 365 LEU A CD1 1 ATOM 2726 C CD2 . LEU A 1 334 ? 15.651 -30.434 -83.668 1.00 30.12 ? 365 LEU A CD2 1 ATOM 2727 N N . LEU A 1 335 ? 12.774 -34.835 -82.082 1.00 36.09 ? 366 LEU A N 1 ATOM 2728 C CA . LEU A 1 335 ? 12.446 -35.813 -81.051 1.00 36.36 ? 366 LEU A CA 1 ATOM 2729 C C . LEU A 1 335 ? 12.566 -37.255 -81.546 1.00 44.31 ? 366 LEU A C 1 ATOM 2730 O O . LEU A 1 335 ? 12.209 -38.192 -80.830 1.00 42.12 ? 366 LEU A O 1 ATOM 2731 C CB . LEU A 1 335 ? 11.029 -35.566 -80.528 1.00 27.25 ? 366 LEU A CB 1 ATOM 2732 C CG . LEU A 1 335 ? 10.761 -34.218 -79.860 1.00 32.89 ? 366 LEU A CG 1 ATOM 2733 C CD1 . LEU A 1 335 ? 9.280 -34.074 -79.564 1.00 29.70 ? 366 LEU A CD1 1 ATOM 2734 C CD2 . LEU A 1 335 ? 11.580 -34.073 -78.585 1.00 23.64 ? 366 LEU A CD2 1 ATOM 2735 N N . PHE A 1 336 ? 13.071 -37.435 -82.762 1.00 34.98 ? 367 PHE A N 1 ATOM 2736 C CA . PHE A 1 336 ? 13.129 -38.765 -83.357 1.00 36.75 ? 367 PHE A CA 1 ATOM 2737 C C . PHE A 1 336 ? 14.194 -39.654 -82.717 1.00 44.27 ? 367 PHE A C 1 ATOM 2738 O O . PHE A 1 336 ? 14.065 -40.878 -82.718 1.00 38.31 ? 367 PHE A O 1 ATOM 2739 C CB . PHE A 1 336 ? 13.366 -38.665 -84.866 1.00 30.24 ? 367 PHE A CB 1 ATOM 2740 C CG . PHE A 1 336 ? 12.150 -38.245 -85.644 1.00 33.82 ? 367 PHE A CG 1 ATOM 2741 C CD1 . PHE A 1 336 ? 10.918 -38.123 -85.019 1.00 33.56 ? 367 PHE A CD1 1 ATOM 2742 C CD2 . PHE A 1 336 ? 12.234 -37.981 -87.003 1.00 35.58 ? 367 PHE A CD2 1 ATOM 2743 C CE1 . PHE A 1 336 ? 9.797 -37.738 -85.732 1.00 33.60 ? 367 PHE A CE1 1 ATOM 2744 C CE2 . PHE A 1 336 ? 11.115 -37.597 -87.721 1.00 31.95 ? 367 PHE A CE2 1 ATOM 2745 C CZ . PHE A 1 336 ? 9.894 -37.474 -87.084 1.00 31.06 ? 367 PHE A CZ 1 ATOM 2746 N N . ASN A 1 337 ? 15.244 -39.048 -82.171 1.00 46.04 ? 368 ASN A N 1 ATOM 2747 C CA . ASN A 1 337 ? 16.279 -39.819 -81.489 1.00 48.30 ? 368 ASN A CA 1 ATOM 2748 C C . ASN A 1 337 ? 16.175 -39.664 -79.973 1.00 48.19 ? 368 ASN A C 1 ATOM 2749 O O . ASN A 1 337 ? 17.113 -39.972 -79.239 1.00 54.41 ? 368 ASN A O 1 ATOM 2750 C CB . ASN A 1 337 ? 17.674 -39.410 -81.975 1.00 48.56 ? 368 ASN A CB 1 ATOM 2751 C CG . ASN A 1 337 ? 18.079 -38.023 -81.504 1.00 76.55 ? 368 ASN A CG 1 ATOM 2752 O OD1 . ASN A 1 337 ? 17.234 -37.157 -81.276 1.00 77.93 ? 368 ASN A OD1 1 ATOM 2753 N ND2 . ASN A 1 337 ? 19.383 -37.806 -81.360 1.00 65.40 ? 368 ASN A ND2 1 ATOM 2754 N N . GLN A 1 338 ? 15.023 -39.188 -79.515 1.00 40.38 ? 369 GLN A N 1 ATOM 2755 C CA . GLN A 1 338 ? 14.778 -38.990 -78.091 1.00 46.32 ? 369 GLN A CA 1 ATOM 2756 C C . GLN A 1 338 ? 13.638 -39.878 -77.608 1.00 43.60 ? 369 GLN A C 1 ATOM 2757 O O . GLN A 1 338 ? 12.865 -40.400 -78.409 1.00 45.44 ? 369 GLN A O 1 ATOM 2758 C CB . GLN A 1 338 ? 14.454 -37.522 -77.802 1.00 43.73 ? 369 GLN A CB 1 ATOM 2759 C CG . GLN A 1 338 ? 15.541 -36.546 -78.214 1.00 48.02 ? 369 GLN A CG 1 ATOM 2760 C CD . GLN A 1 338 ? 16.728 -36.567 -77.276 1.00 48.43 ? 369 GLN A CD 1 ATOM 2761 O OE1 . GLN A 1 338 ? 16.568 -36.625 -76.057 1.00 53.44 ? 369 GLN A OE1 1 ATOM 2762 N NE2 . GLN A 1 338 ? 17.929 -36.524 -77.840 1.00 54.01 ? 369 GLN A NE2 1 ATOM 2763 N N . GLN A 1 339 ? 13.540 -40.048 -76.294 1.00 42.03 ? 370 GLN A N 1 ATOM 2764 C CA . GLN A 1 339 ? 12.427 -40.779 -75.700 1.00 36.64 ? 370 GLN A CA 1 ATOM 2765 C C . GLN A 1 339 ? 11.246 -39.840 -75.502 1.00 38.77 ? 370 GLN A C 1 ATOM 2766 O O . GLN A 1 339 ? 11.341 -38.859 -74.763 1.00 41.46 ? 370 GLN A O 1 ATOM 2767 C CB . GLN A 1 339 ? 12.834 -41.410 -74.369 1.00 40.02 ? 370 GLN A CB 1 ATOM 2768 C CG . GLN A 1 339 ? 13.832 -42.543 -74.504 1.00 44.15 ? 370 GLN A CG 1 ATOM 2769 C CD . GLN A 1 339 ? 14.277 -43.093 -73.165 1.00 46.60 ? 370 GLN A CD 1 ATOM 2770 O OE1 . GLN A 1 339 ? 14.702 -42.347 -72.282 1.00 60.65 ? 370 GLN A OE1 1 ATOM 2771 N NE2 . GLN A 1 339 ? 14.177 -44.406 -73.005 1.00 49.70 ? 370 GLN A NE2 1 ATOM 2772 N N . PHE A 1 340 ? 10.137 -40.140 -76.169 1.00 29.74 ? 371 PHE A N 1 ATOM 2773 C CA . PHE A 1 340 ? 8.976 -39.259 -76.160 1.00 26.47 ? 371 PHE A CA 1 ATOM 2774 C C . PHE A 1 340 ? 7.704 -40.034 -76.494 1.00 29.81 ? 371 PHE A C 1 ATOM 2775 O O . PHE A 1 340 ? 7.683 -40.839 -77.425 1.00 33.76 ? 371 PHE A O 1 ATOM 2776 C CB . PHE A 1 340 ? 9.183 -38.109 -77.152 1.00 29.83 ? 371 PHE A CB 1 ATOM 2777 C CG . PHE A 1 340 ? 8.133 -37.034 -77.074 1.00 30.55 ? 371 PHE A CG 1 ATOM 2778 C CD1 . PHE A 1 340 ? 8.236 -36.012 -76.145 1.00 28.19 ? 371 PHE A CD1 1 ATOM 2779 C CD2 . PHE A 1 340 ? 7.052 -37.037 -77.942 1.00 28.41 ? 371 PHE A CD2 1 ATOM 2780 C CE1 . PHE A 1 340 ? 7.277 -35.019 -76.074 1.00 28.36 ? 371 PHE A CE1 1 ATOM 2781 C CE2 . PHE A 1 340 ? 6.088 -36.045 -77.875 1.00 27.25 ? 371 PHE A CE2 1 ATOM 2782 C CZ . PHE A 1 340 ? 6.201 -35.037 -76.940 1.00 27.36 ? 371 PHE A CZ 1 ATOM 2783 N N . GLN A 1 341 ? 6.646 -39.793 -75.728 1.00 27.86 ? 372 GLN A N 1 ATOM 2784 C CA . GLN A 1 341 ? 5.379 -40.475 -75.953 1.00 30.42 ? 372 GLN A CA 1 ATOM 2785 C C . GLN A 1 341 ? 4.444 -39.621 -76.799 1.00 29.52 ? 372 GLN A C 1 ATOM 2786 O O . GLN A 1 341 ? 4.014 -38.552 -76.370 1.00 34.47 ? 372 GLN A O 1 ATOM 2787 C CB . GLN A 1 341 ? 4.712 -40.823 -74.620 1.00 31.93 ? 372 GLN A CB 1 ATOM 2788 C CG . GLN A 1 341 ? 5.550 -41.711 -73.720 1.00 26.52 ? 372 GLN A CG 1 ATOM 2789 C CD . GLN A 1 341 ? 5.740 -43.101 -74.289 1.00 25.51 ? 372 GLN A CD 1 ATOM 2790 O OE1 . GLN A 1 341 ? 4.773 -43.790 -74.611 1.00 31.81 ? 372 GLN A OE1 1 ATOM 2791 N NE2 . GLN A 1 341 ? 6.993 -43.522 -74.419 1.00 24.06 ? 372 GLN A NE2 1 ATOM 2792 N N . TYR A 1 342 ? 4.130 -40.093 -78.001 1.00 29.49 ? 373 TYR A N 1 ATOM 2793 C CA . TYR A 1 342 ? 3.228 -39.362 -78.884 1.00 26.03 ? 373 TYR A CA 1 ATOM 2794 C C . TYR A 1 342 ? 1.777 -39.590 -78.482 1.00 28.22 ? 373 TYR A C 1 ATOM 2795 O O . TYR A 1 342 ? 0.991 -40.187 -79.217 1.00 34.27 ? 373 TYR A O 1 ATOM 2796 C CB . TYR A 1 342 ? 3.462 -39.760 -80.341 1.00 25.80 ? 373 TYR A CB 1 ATOM 2797 C CG . TYR A 1 342 ? 4.834 -39.363 -80.828 1.00 29.53 ? 373 TYR A CG 1 ATOM 2798 C CD1 . TYR A 1 342 ? 5.118 -38.042 -81.156 1.00 26.50 ? 373 TYR A CD1 1 ATOM 2799 C CD2 . TYR A 1 342 ? 5.854 -40.300 -80.936 1.00 29.74 ? 373 TYR A CD2 1 ATOM 2800 C CE1 . TYR A 1 342 ? 6.374 -37.668 -81.589 1.00 28.39 ? 373 TYR A CE1 1 ATOM 2801 C CE2 . TYR A 1 342 ? 7.113 -39.936 -81.369 1.00 26.93 ? 373 TYR A CE2 1 ATOM 2802 C CZ . TYR A 1 342 ? 7.368 -38.620 -81.694 1.00 34.76 ? 373 TYR A CZ 1 ATOM 2803 O OH . TYR A 1 342 ? 8.621 -38.253 -82.125 1.00 36.01 ? 373 TYR A OH 1 ATOM 2804 N N . GLN A 1 343 ? 1.447 -39.103 -77.292 1.00 24.38 ? 374 GLN A N 1 ATOM 2805 C CA . GLN A 1 343 ? 0.095 -39.136 -76.756 1.00 26.29 ? 374 GLN A CA 1 ATOM 2806 C C . GLN A 1 343 ? -0.020 -38.015 -75.733 1.00 28.52 ? 374 GLN A C 1 ATOM 2807 O O . GLN A 1 343 ? 0.995 -37.519 -75.242 1.00 33.47 ? 374 GLN A O 1 ATOM 2808 C CB . GLN A 1 343 ? -0.216 -40.492 -76.120 1.00 29.08 ? 374 GLN A CB 1 ATOM 2809 C CG . GLN A 1 343 ? 0.715 -40.865 -74.974 1.00 33.94 ? 374 GLN A CG 1 ATOM 2810 C CD . GLN A 1 343 ? 0.339 -42.178 -74.316 1.00 36.33 ? 374 GLN A CD 1 ATOM 2811 O OE1 . GLN A 1 343 ? -0.748 -42.317 -73.755 1.00 52.83 ? 374 GLN A OE1 1 ATOM 2812 N NE2 . GLN A 1 343 ? 1.240 -43.152 -74.383 1.00 34.83 ? 374 GLN A NE2 1 ATOM 2813 N N . ASN A 1 344 ? -1.243 -37.604 -75.417 1.00 26.62 ? 375 ASN A N 1 ATOM 2814 C CA . ASN A 1 344 ? -1.434 -36.545 -74.432 1.00 22.99 ? 375 ASN A CA 1 ATOM 2815 C C . ASN A 1 344 ? -2.833 -36.529 -73.833 1.00 24.15 ? 375 ASN A C 1 ATOM 2816 O O . ASN A 1 344 ? -3.823 -36.766 -74.524 1.00 33.64 ? 375 ASN A O 1 ATOM 2817 C CB . ASN A 1 344 ? -1.125 -35.180 -75.049 1.00 35.78 ? 375 ASN A CB 1 ATOM 2818 C CG . ASN A 1 344 ? -1.217 -34.053 -74.041 1.00 33.69 ? 375 ASN A CG 1 ATOM 2819 O OD1 . ASN A 1 344 ? -0.432 -33.987 -73.095 1.00 35.25 ? 375 ASN A OD1 1 ATOM 2820 N ND2 . ASN A 1 344 ? -2.178 -33.159 -74.240 1.00 31.11 ? 375 ASN A ND2 1 ATOM 2821 N N . ARG A 1 345 ? -2.895 -36.247 -72.536 1.00 21.65 ? 376 ARG A N 1 ATOM 2822 C CA . ARG A 1 345 ? -4.153 -36.149 -71.814 1.00 22.63 ? 376 ARG A CA 1 ATOM 2823 C C . ARG A 1 345 ? -4.233 -34.764 -71.187 1.00 27.20 ? 376 ARG A C 1 ATOM 2824 O O . ARG A 1 345 ? -3.319 -34.353 -70.476 1.00 31.84 ? 376 ARG A O 1 ATOM 2825 C CB . ARG A 1 345 ? -4.253 -37.237 -70.743 1.00 19.93 ? 376 ARG A CB 1 ATOM 2826 C CG . ARG A 1 345 ? -5.651 -37.461 -70.187 1.00 23.15 ? 376 ARG A CG 1 ATOM 2827 C CD . ARG A 1 345 ? -6.546 -38.204 -71.174 1.00 21.51 ? 376 ARG A CD 1 ATOM 2828 N NE . ARG A 1 345 ? -6.015 -39.519 -71.525 1.00 29.55 ? 376 ARG A NE 1 ATOM 2829 C CZ . ARG A 1 345 ? -6.227 -40.632 -70.828 1.00 24.84 ? 376 ARG A CZ 1 ATOM 2830 N NH1 . ARG A 1 345 ? -6.959 -40.608 -69.724 1.00 22.63 ? 376 ARG A NH1 1 ATOM 2831 N NH2 . ARG A 1 345 ? -5.696 -41.775 -71.237 1.00 28.04 ? 376 ARG A NH2 1 ATOM 2832 N N . ILE A 1 346 ? -5.316 -34.043 -71.460 1.00 25.49 ? 377 ILE A N 1 ATOM 2833 C CA . ILE A 1 346 ? -5.461 -32.671 -70.974 1.00 27.07 ? 377 ILE A CA 1 ATOM 2834 C C . ILE A 1 346 ? -5.629 -32.619 -69.459 1.00 27.20 ? 377 ILE A C 1 ATOM 2835 O O . ILE A 1 346 ? -6.553 -33.213 -68.904 1.00 29.21 ? 377 ILE A O 1 ATOM 2836 C CB . ILE A 1 346 ? -6.662 -31.958 -71.631 1.00 27.99 ? 377 ILE A CB 1 ATOM 2837 C CG1 . ILE A 1 346 ? -6.481 -31.883 -73.149 1.00 26.24 ? 377 ILE A CG1 1 ATOM 2838 C CG2 . ILE A 1 346 ? -6.831 -30.565 -71.055 1.00 23.72 ? 377 ILE A CG2 1 ATOM 2839 C CD1 . ILE A 1 346 ? -5.214 -31.177 -73.582 1.00 22.94 ? 377 ILE A CD1 1 ATOM 2840 N N . ALA A 1 347 ? -4.731 -31.897 -68.795 1.00 29.99 ? 378 ALA A N 1 ATOM 2841 C CA . ALA A 1 347 ? -4.765 -31.782 -67.342 1.00 25.13 ? 378 ALA A CA 1 ATOM 2842 C C . ALA A 1 347 ? -5.754 -30.712 -66.900 1.00 30.41 ? 378 ALA A C 1 ATOM 2843 O O . ALA A 1 347 ? -5.889 -29.673 -67.546 1.00 33.74 ? 378 ALA A O 1 ATOM 2844 C CB . ALA A 1 347 ? -3.378 -31.475 -66.800 1.00 26.23 ? 378 ALA A CB 1 ATOM 2845 N N . SER A 1 348 ? -6.445 -30.975 -65.796 1.00 31.99 ? 379 SER A N 1 ATOM 2846 C CA . SER A 1 348 ? -7.390 -30.019 -65.237 1.00 30.87 ? 379 SER A CA 1 ATOM 2847 C C . SER A 1 348 ? -6.682 -28.727 -64.841 1.00 30.77 ? 379 SER A C 1 ATOM 2848 O O . SER A 1 348 ? -7.232 -27.636 -64.987 1.00 34.26 ? 379 SER A O 1 ATOM 2849 C CB . SER A 1 348 ? -8.108 -30.622 -64.029 1.00 29.84 ? 379 SER A CB 1 ATOM 2850 O OG . SER A 1 348 ? -9.056 -29.714 -63.493 1.00 35.73 ? 379 SER A OG 1 ATOM 2851 N N . GLU A 1 349 ? -5.456 -28.860 -64.345 1.00 33.77 ? 380 GLU A N 1 ATOM 2852 C CA . GLU A 1 349 ? -4.670 -27.707 -63.923 1.00 35.90 ? 380 GLU A CA 1 ATOM 2853 C C . GLU A 1 349 ? -4.263 -26.836 -65.108 1.00 36.60 ? 380 GLU A C 1 ATOM 2854 O O . GLU A 1 349 ? -4.081 -25.629 -64.961 1.00 38.70 ? 380 GLU A O 1 ATOM 2855 C CB . GLU A 1 349 ? -3.429 -28.157 -63.155 1.00 31.67 ? 380 GLU A CB 1 ATOM 2856 C CG . GLU A 1 349 ? -3.736 -28.848 -61.838 1.00 34.37 ? 380 GLU A CG 1 ATOM 2857 C CD . GLU A 1 349 ? -3.644 -30.357 -61.935 1.00 41.94 ? 380 GLU A CD 1 ATOM 2858 O OE1 . GLU A 1 349 ? -3.792 -30.893 -63.054 1.00 40.37 ? 380 GLU A OE1 1 ATOM 2859 O OE2 . GLU A 1 349 ? -3.417 -31.005 -60.891 1.00 34.65 ? 380 GLU A OE2 1 ATOM 2860 N N . PHE A 1 350 ? -4.114 -27.453 -66.276 1.00 32.71 ? 381 PHE A N 1 ATOM 2861 C CA . PHE A 1 350 ? -3.823 -26.710 -67.495 1.00 28.27 ? 381 PHE A CA 1 ATOM 2862 C C . PHE A 1 350 ? -5.016 -25.832 -67.841 1.00 36.46 ? 381 PHE A C 1 ATOM 2863 O O . PHE A 1 350 ? -4.864 -24.667 -68.205 1.00 41.71 ? 381 PHE A O 1 ATOM 2864 C CB . PHE A 1 350 ? -3.508 -27.656 -68.653 1.00 31.71 ? 381 PHE A CB 1 ATOM 2865 C CG . PHE A 1 350 ? -2.922 -26.970 -69.856 1.00 35.70 ? 381 PHE A CG 1 ATOM 2866 C CD1 . PHE A 1 350 ? -2.199 -25.795 -69.720 1.00 33.11 ? 381 PHE A CD1 1 ATOM 2867 C CD2 . PHE A 1 350 ? -3.098 -27.498 -71.125 1.00 35.88 ? 381 PHE A CD2 1 ATOM 2868 C CE1 . PHE A 1 350 ? -1.655 -25.168 -70.825 1.00 37.56 ? 381 PHE A CE1 1 ATOM 2869 C CE2 . PHE A 1 350 ? -2.562 -26.872 -72.233 1.00 28.49 ? 381 PHE A CE2 1 ATOM 2870 C CZ . PHE A 1 350 ? -1.839 -25.705 -72.083 1.00 32.97 ? 381 PHE A CZ 1 ATOM 2871 N N . ASN A 1 351 ? -6.205 -26.411 -67.716 1.00 34.66 ? 382 ASN A N 1 ATOM 2872 C CA . ASN A 1 351 ? -7.450 -25.692 -67.947 1.00 33.21 ? 382 ASN A CA 1 ATOM 2873 C C . ASN A 1 351 ? -7.596 -24.510 -66.998 1.00 41.65 ? 382 ASN A C 1 ATOM 2874 O O . ASN A 1 351 ? -7.988 -23.417 -67.406 1.00 43.29 ? 382 ASN A O 1 ATOM 2875 C CB . ASN A 1 351 ? -8.642 -26.640 -67.795 1.00 27.06 ? 382 ASN A CB 1 ATOM 2876 C CG . ASN A 1 351 ? -9.973 -25.943 -67.984 1.00 28.86 ? 382 ASN A CG 1 ATOM 2877 O OD1 . ASN A 1 351 ? -10.089 -24.999 -68.765 1.00 42.25 ? 382 ASN A OD1 1 ATOM 2878 N ND2 . ASN A 1 351 ? -10.988 -26.403 -67.263 1.00 53.50 ? 382 ASN A ND2 1 ATOM 2879 N N . THR A 1 352 ? -7.266 -24.737 -65.731 1.00 41.39 ? 383 THR A N 1 ATOM 2880 C CA . THR A 1 352 ? -7.421 -23.719 -64.701 1.00 37.29 ? 383 THR A CA 1 ATOM 2881 C C . THR A 1 352 ? -6.475 -22.538 -64.912 1.00 33.12 ? 383 THR A C 1 ATOM 2882 O O . THR A 1 352 ? -6.897 -21.385 -64.855 1.00 40.82 ? 383 THR A O 1 ATOM 2883 C CB . THR A 1 352 ? -7.191 -24.308 -63.295 1.00 38.84 ? 383 THR A CB 1 ATOM 2884 O OG1 . THR A 1 352 ? -8.195 -25.294 -63.019 1.00 39.75 ? 383 THR A OG1 1 ATOM 2885 C CG2 . THR A 1 352 ? -7.265 -23.217 -62.237 1.00 35.98 ? 383 THR A CG2 1 ATOM 2886 N N . LEU A 1 353 ? -5.201 -22.825 -65.169 1.00 32.55 ? 384 LEU A N 1 ATOM 2887 C CA . LEU A 1 353 ? -4.203 -21.768 -65.321 1.00 37.15 ? 384 LEU A CA 1 ATOM 2888 C C . LEU A 1 353 ? -4.426 -20.949 -66.589 1.00 39.69 ? 384 LEU A C 1 ATOM 2889 O O . LEU A 1 353 ? -3.926 -19.829 -66.708 1.00 40.83 ? 384 LEU A O 1 ATOM 2890 C CB . LEU A 1 353 ? -2.782 -22.354 -65.314 1.00 29.09 ? 384 LEU A CB 1 ATOM 2891 C CG . LEU A 1 353 ? -2.249 -23.226 -66.456 1.00 34.31 ? 384 LEU A CG 1 ATOM 2892 C CD1 . LEU A 1 353 ? -1.672 -22.393 -67.599 1.00 35.17 ? 384 LEU A CD1 1 ATOM 2893 C CD2 . LEU A 1 353 ? -1.199 -24.191 -65.923 1.00 33.36 ? 384 LEU A CD2 1 ATOM 2894 N N . TYR A 1 354 ? -5.174 -21.507 -67.535 1.00 36.77 ? 385 TYR A N 1 ATOM 2895 C CA . TYR A 1 354 ? -5.414 -20.833 -68.805 1.00 34.91 ? 385 TYR A CA 1 ATOM 2896 C C . TYR A 1 354 ? -6.630 -19.918 -68.742 1.00 37.48 ? 385 TYR A C 1 ATOM 2897 O O . TYR A 1 354 ? -7.034 -19.345 -69.752 1.00 38.77 ? 385 TYR A O 1 ATOM 2898 C CB . TYR A 1 354 ? -5.592 -21.850 -69.930 1.00 31.40 ? 385 TYR A CB 1 ATOM 2899 C CG . TYR A 1 354 ? -4.677 -21.613 -71.109 1.00 33.11 ? 385 TYR A CG 1 ATOM 2900 C CD1 . TYR A 1 354 ? -4.922 -20.585 -72.010 1.00 38.04 ? 385 TYR A CD1 1 ATOM 2901 C CD2 . TYR A 1 354 ? -3.570 -22.421 -71.324 1.00 33.69 ? 385 TYR A CD2 1 ATOM 2902 C CE1 . TYR A 1 354 ? -4.085 -20.367 -73.088 1.00 32.75 ? 385 TYR A CE1 1 ATOM 2903 C CE2 . TYR A 1 354 ? -2.729 -22.213 -72.401 1.00 38.74 ? 385 TYR A CE2 1 ATOM 2904 C CZ . TYR A 1 354 ? -2.992 -21.186 -73.280 1.00 39.39 ? 385 TYR A CZ 1 ATOM 2905 O OH . TYR A 1 354 ? -2.157 -20.976 -74.355 1.00 41.89 ? 385 TYR A OH 1 ATOM 2906 N N . HIS A 1 355 ? -7.213 -19.785 -67.554 1.00 37.62 ? 386 HIS A N 1 ATOM 2907 C CA . HIS A 1 355 ? -8.328 -18.866 -67.355 1.00 39.84 ? 386 HIS A CA 1 ATOM 2908 C C . HIS A 1 355 ? -7.814 -17.435 -67.261 1.00 42.98 ? 386 HIS A C 1 ATOM 2909 O O . HIS A 1 355 ? -7.903 -16.800 -66.210 1.00 43.14 ? 386 HIS A O 1 ATOM 2910 C CB . HIS A 1 355 ? -9.122 -19.237 -66.101 1.00 41.60 ? 386 HIS A CB 1 ATOM 2911 C CG . HIS A 1 355 ? -9.898 -20.511 -66.233 1.00 45.71 ? 386 HIS A CG 1 ATOM 2912 N ND1 . HIS A 1 355 ? -10.497 -21.136 -65.160 1.00 48.95 ? 386 HIS A ND1 1 ATOM 2913 C CD2 . HIS A 1 355 ? -10.176 -21.276 -67.316 1.00 46.46 ? 386 HIS A CD2 1 ATOM 2914 C CE1 . HIS A 1 355 ? -11.108 -22.232 -65.576 1.00 48.28 ? 386 HIS A CE1 1 ATOM 2915 N NE2 . HIS A 1 355 ? -10.928 -22.340 -66.879 1.00 52.29 ? 386 HIS A NE2 1 ATOM 2916 N N . TRP A 1 356 ? -7.275 -16.938 -68.371 1.00 37.89 ? 387 TRP A N 1 ATOM 2917 C CA . TRP A 1 356 ? -6.682 -15.606 -68.427 1.00 36.45 ? 387 TRP A CA 1 ATOM 2918 C C . TRP A 1 356 ? -7.738 -14.523 -68.598 1.00 41.32 ? 387 TRP A C 1 ATOM 2919 O O . TRP A 1 356 ? -7.764 -13.823 -69.611 1.00 42.84 ? 387 TRP A O 1 ATOM 2920 C CB . TRP A 1 356 ? -5.674 -15.518 -69.572 1.00 34.04 ? 387 TRP A CB 1 ATOM 2921 C CG . TRP A 1 356 ? -4.551 -16.494 -69.467 1.00 35.96 ? 387 TRP A CG 1 ATOM 2922 C CD1 . TRP A 1 356 ? -4.151 -17.168 -68.352 1.00 35.57 ? 387 TRP A CD1 1 ATOM 2923 C CD2 . TRP A 1 356 ? -3.682 -16.914 -70.523 1.00 36.62 ? 387 TRP A CD2 1 ATOM 2924 N NE1 . TRP A 1 356 ? -3.082 -17.981 -68.645 1.00 34.24 ? 387 TRP A NE1 1 ATOM 2925 C CE2 . TRP A 1 356 ? -2.775 -17.843 -69.974 1.00 40.04 ? 387 TRP A CE2 1 ATOM 2926 C CE3 . TRP A 1 356 ? -3.581 -16.593 -71.881 1.00 30.59 ? 387 TRP A CE3 1 ATOM 2927 C CZ2 . TRP A 1 356 ? -1.783 -18.456 -70.735 1.00 41.85 ? 387 TRP A CZ2 1 ATOM 2928 C CZ3 . TRP A 1 356 ? -2.594 -17.202 -72.635 1.00 31.23 ? 387 TRP A CZ3 1 ATOM 2929 C CH2 . TRP A 1 356 ? -1.708 -18.121 -72.060 1.00 41.67 ? 387 TRP A CH2 1 ATOM 2930 N N . HIS A 1 357 ? -8.606 -14.392 -67.603 1.00 40.45 ? 388 HIS A N 1 ATOM 2931 C CA . HIS A 1 357 ? -9.651 -13.375 -67.616 1.00 41.85 ? 388 HIS A CA 1 ATOM 2932 C C . HIS A 1 357 ? -9.141 -11.926 -67.685 1.00 41.94 ? 388 HIS A C 1 ATOM 2933 O O . HIS A 1 357 ? -9.775 -11.095 -68.336 1.00 43.95 ? 388 HIS A O 1 ATOM 2934 C CB . HIS A 1 357 ? -10.552 -13.545 -66.391 1.00 48.06 ? 388 HIS A CB 1 ATOM 2935 C CG . HIS A 1 357 ? -11.224 -14.881 -66.321 1.00 54.72 ? 388 HIS A CG 1 ATOM 2936 N ND1 . HIS A 1 357 ? -10.941 -15.806 -65.340 1.00 51.61 ? 388 HIS A ND1 1 ATOM 2937 C CD2 . HIS A 1 357 ? -12.155 -15.452 -67.121 1.00 50.04 ? 388 HIS A CD2 1 ATOM 2938 C CE1 . HIS A 1 357 ? -11.677 -16.887 -65.533 1.00 51.78 ? 388 HIS A CE1 1 ATOM 2939 N NE2 . HIS A 1 357 ? -12.421 -16.698 -66.607 1.00 54.68 ? 388 HIS A NE2 1 ATOM 2940 N N . PRO A 1 358 ? -8.010 -11.607 -67.020 1.00 41.93 ? 389 PRO A N 1 ATOM 2941 C CA . PRO A 1 358 ? -7.523 -10.226 -67.156 1.00 39.81 ? 389 PRO A CA 1 ATOM 2942 C C . PRO A 1 358 ? -7.153 -9.798 -68.582 1.00 38.60 ? 389 PRO A C 1 ATOM 2943 O O . PRO A 1 358 ? -6.977 -8.601 -68.805 1.00 42.11 ? 389 PRO A O 1 ATOM 2944 C CB . PRO A 1 358 ? -6.281 -10.211 -66.262 1.00 39.32 ? 389 PRO A CB 1 ATOM 2945 C CG . PRO A 1 358 ? -6.573 -11.216 -65.222 1.00 42.29 ? 389 PRO A CG 1 ATOM 2946 C CD . PRO A 1 358 ? -7.301 -12.316 -65.937 1.00 38.93 ? 389 PRO A CD 1 ATOM 2947 N N . LEU A 1 359 ? -7.035 -10.742 -69.514 1.00 40.89 ? 390 LEU A N 1 ATOM 2948 C CA . LEU A 1 359 ? -6.740 -10.415 -70.911 1.00 38.43 ? 390 LEU A CA 1 ATOM 2949 C C . LEU A 1 359 ? -7.775 -9.469 -71.513 1.00 42.08 ? 390 LEU A C 1 ATOM 2950 O O . LEU A 1 359 ? -7.435 -8.573 -72.285 1.00 46.01 ? 390 LEU A O 1 ATOM 2951 C CB . LEU A 1 359 ? -6.672 -11.681 -71.768 1.00 35.83 ? 390 LEU A CB 1 ATOM 2952 C CG . LEU A 1 359 ? -5.341 -12.405 -71.961 1.00 41.20 ? 390 LEU A CG 1 ATOM 2953 C CD1 . LEU A 1 359 ? -5.494 -13.486 -73.022 1.00 31.84 ? 390 LEU A CD1 1 ATOM 2954 C CD2 . LEU A 1 359 ? -4.234 -11.432 -72.339 1.00 33.69 ? 390 LEU A CD2 1 ATOM 2955 N N . LEU A 1 360 ? -9.039 -9.683 -71.160 1.00 37.61 ? 391 LEU A N 1 ATOM 2956 C CA . LEU A 1 360 ? -10.144 -8.916 -71.726 1.00 46.97 ? 391 LEU A CA 1 ATOM 2957 C C . LEU A 1 360 ? -10.058 -7.429 -71.387 1.00 45.56 ? 391 LEU A C 1 ATOM 2958 O O . LEU A 1 360 ? -9.745 -7.061 -70.255 1.00 44.17 ? 391 LEU A O 1 ATOM 2959 C CB . LEU A 1 360 ? -11.481 -9.480 -71.240 1.00 48.45 ? 391 LEU A CB 1 ATOM 2960 C CG . LEU A 1 360 ? -11.738 -10.962 -71.519 1.00 51.17 ? 391 LEU A CG 1 ATOM 2961 C CD1 . LEU A 1 360 ? -13.041 -11.408 -70.873 1.00 57.00 ? 391 LEU A CD1 1 ATOM 2962 C CD2 . LEU A 1 360 ? -11.754 -11.240 -73.016 1.00 37.96 ? 391 LEU A CD2 1 ATOM 2963 N N . PRO A 1 361 ? -10.335 -6.571 -72.379 1.00 39.31 ? 392 PRO A N 1 ATOM 2964 C CA . PRO A 1 361 ? -10.360 -5.116 -72.204 1.00 39.55 ? 392 PRO A CA 1 ATOM 2965 C C . PRO A 1 361 ? -11.686 -4.643 -71.619 1.00 43.84 ? 392 PRO A C 1 ATOM 2966 O O . PRO A 1 361 ? -12.559 -5.467 -71.341 1.00 43.55 ? 392 PRO A O 1 ATOM 2967 C CB . PRO A 1 361 ? -10.177 -4.599 -73.628 1.00 40.33 ? 392 PRO A CB 1 ATOM 2968 C CG . PRO A 1 361 ? -10.843 -5.637 -74.467 1.00 40.06 ? 392 PRO A CG 1 ATOM 2969 C CD . PRO A 1 361 ? -10.584 -6.958 -73.779 1.00 42.62 ? 392 PRO A CD 1 ATOM 2970 N N . ASP A 1 362 ? -11.833 -3.335 -71.431 1.00 44.95 ? 393 ASP A N 1 ATOM 2971 C CA . ASP A 1 362 ? -13.088 -2.775 -70.940 1.00 42.79 ? 393 ASP A CA 1 ATOM 2972 C C . ASP A 1 362 ? -14.109 -2.724 -72.067 1.00 42.07 ? 393 ASP A C 1 ATOM 2973 O O . ASP A 1 362 ? -15.286 -3.027 -71.872 1.00 41.85 ? 393 ASP A O 1 ATOM 2974 C CB . ASP A 1 362 ? -12.871 -1.378 -70.358 1.00 34.78 ? 393 ASP A CB 1 ATOM 2975 C CG . ASP A 1 362 ? -11.969 -1.388 -69.144 1.00 48.35 ? 393 ASP A CG 1 ATOM 2976 O OD1 . ASP A 1 362 ? -12.045 -2.353 -68.354 1.00 44.16 ? 393 ASP A OD1 1 ATOM 2977 O OD2 . ASP A 1 362 ? -11.183 -0.430 -68.981 1.00 48.31 ? 393 ASP A OD2 1 ATOM 2978 N N . THR A 1 363 ? -13.645 -2.332 -73.249 1.00 40.63 ? 394 THR A N 1 ATOM 2979 C CA . THR A 1 363 ? -14.486 -2.289 -74.436 1.00 40.49 ? 394 THR A CA 1 ATOM 2980 C C . THR A 1 363 ? -13.751 -2.902 -75.619 1.00 44.67 ? 394 THR A C 1 ATOM 2981 O O . THR A 1 363 ? -12.528 -3.037 -75.597 1.00 46.91 ? 394 THR A O 1 ATOM 2982 C CB . THR A 1 363 ? -14.901 -0.850 -74.797 1.00 44.06 ? 394 THR A CB 1 ATOM 2983 O OG1 . THR A 1 363 ? -13.728 -0.057 -75.023 1.00 49.22 ? 394 THR A OG1 1 ATOM 2984 C CG2 . THR A 1 363 ? -15.728 -0.228 -73.680 1.00 44.14 ? 394 THR A CG2 1 ATOM 2985 N N . PHE A 1 364 ? -14.500 -3.274 -76.650 1.00 45.34 ? 395 PHE A N 1 ATOM 2986 C CA . PHE A 1 364 ? -13.906 -3.808 -77.868 1.00 42.09 ? 395 PHE A CA 1 ATOM 2987 C C . PHE A 1 364 ? -13.970 -2.752 -78.962 1.00 39.07 ? 395 PHE A C 1 ATOM 2988 O O . PHE A 1 364 ? -15.051 -2.355 -79.396 1.00 42.89 ? 395 PHE A O 1 ATOM 2989 C CB . PHE A 1 364 ? -14.611 -5.097 -78.295 1.00 45.66 ? 395 PHE A CB 1 ATOM 2990 C CG . PHE A 1 364 ? -14.594 -6.167 -77.240 1.00 47.62 ? 395 PHE A CG 1 ATOM 2991 C CD1 . PHE A 1 364 ? -13.516 -7.033 -77.126 1.00 40.61 ? 395 PHE A CD1 1 ATOM 2992 C CD2 . PHE A 1 364 ? -15.648 -6.297 -76.350 1.00 50.89 ? 395 PHE A CD2 1 ATOM 2993 C CE1 . PHE A 1 364 ? -13.495 -8.011 -76.150 1.00 44.28 ? 395 PHE A CE1 1 ATOM 2994 C CE2 . PHE A 1 364 ? -15.632 -7.273 -75.372 1.00 52.08 ? 395 PHE A CE2 1 ATOM 2995 C CZ . PHE A 1 364 ? -14.555 -8.131 -75.271 1.00 50.69 ? 395 PHE A CZ 1 ATOM 2996 N N . ASN A 1 365 ? -12.801 -2.297 -79.397 1.00 39.19 ? 396 ASN A N 1 ATOM 2997 C CA . ASN A 1 365 ? -12.708 -1.156 -80.298 1.00 40.05 ? 396 ASN A CA 1 ATOM 2998 C C . ASN A 1 365 ? -12.496 -1.552 -81.754 1.00 43.39 ? 396 ASN A C 1 ATOM 2999 O O . ASN A 1 365 ? -11.451 -2.092 -82.118 1.00 51.27 ? 396 ASN A O 1 ATOM 3000 C CB . ASN A 1 365 ? -11.578 -0.232 -79.844 1.00 39.10 ? 396 ASN A CB 1 ATOM 3001 C CG . ASN A 1 365 ? -11.664 0.105 -78.369 1.00 46.33 ? 396 ASN A CG 1 ATOM 3002 O OD1 . ASN A 1 365 ? -12.750 0.146 -77.791 1.00 47.25 ? 396 ASN A OD1 1 ATOM 3003 N ND2 . ASN A 1 365 ? -10.514 0.345 -77.750 1.00 47.24 ? 396 ASN A ND2 1 ATOM 3004 N N . ILE A 1 366 ? -13.500 -1.277 -82.581 1.00 42.17 ? 397 ILE A N 1 ATOM 3005 C CA . ILE A 1 366 ? -13.427 -1.548 -84.013 1.00 47.25 ? 397 ILE A CA 1 ATOM 3006 C C . ILE A 1 366 ? -13.792 -0.284 -84.781 1.00 53.13 ? 397 ILE A C 1 ATOM 3007 O O . ILE A 1 366 ? -14.851 0.300 -84.553 1.00 57.56 ? 397 ILE A O 1 ATOM 3008 C CB . ILE A 1 366 ? -14.355 -2.706 -84.417 1.00 45.48 ? 397 ILE A CB 1 ATOM 3009 C CG1 . ILE A 1 366 ? -13.950 -3.980 -83.672 1.00 44.00 ? 397 ILE A CG1 1 ATOM 3010 C CG2 . ILE A 1 366 ? -14.310 -2.929 -85.919 1.00 41.03 ? 397 ILE A CG2 1 ATOM 3011 C CD1 . ILE A 1 366 ? -14.965 -5.089 -83.751 1.00 46.40 ? 397 ILE A CD1 1 ATOM 3012 N N . GLU A 1 367 ? -12.909 0.124 -85.690 1.00 60.21 ? 398 GLU A N 1 ATOM 3013 C CA . GLU A 1 367 ? -12.980 1.438 -86.328 1.00 63.98 ? 398 GLU A CA 1 ATOM 3014 C C . GLU A 1 367 ? -13.021 2.529 -85.265 1.00 67.20 ? 398 GLU A C 1 ATOM 3015 O O . GLU A 1 367 ? -12.062 2.712 -84.516 1.00 71.88 ? 398 GLU A O 1 ATOM 3016 C CB . GLU A 1 367 ? -14.193 1.549 -87.258 1.00 68.19 ? 398 GLU A CB 1 ATOM 3017 C CG . GLU A 1 367 ? -13.925 1.063 -88.672 1.00 74.86 ? 398 GLU A CG 1 ATOM 3018 C CD . GLU A 1 367 ? -15.140 1.162 -89.573 1.00 92.40 ? 398 GLU A CD 1 ATOM 3019 O OE1 . GLU A 1 367 ? -15.956 2.089 -89.378 1.00 93.91 ? 398 GLU A OE1 1 ATOM 3020 O OE2 . GLU A 1 367 ? -15.279 0.311 -90.478 1.00 79.98 ? 398 GLU A OE2 1 ATOM 3021 N N . ASP A 1 368 ? -14.135 3.249 -85.200 1.00 65.45 ? 399 ASP A N 1 ATOM 3022 C CA . ASP A 1 368 ? -14.308 4.294 -84.199 1.00 77.21 ? 399 ASP A CA 1 ATOM 3023 C C . ASP A 1 368 ? -15.439 3.940 -83.241 1.00 75.44 ? 399 ASP A C 1 ATOM 3024 O O . ASP A 1 368 ? -15.982 4.806 -82.554 1.00 82.22 ? 399 ASP A O 1 ATOM 3025 C CB . ASP A 1 368 ? -14.571 5.643 -84.870 1.00 78.89 ? 399 ASP A CB 1 ATOM 3026 C CG . ASP A 1 368 ? -15.502 5.530 -86.061 1.00 104.46 ? 399 ASP A CG 1 ATOM 3027 O OD1 . ASP A 1 368 ? -16.444 4.710 -86.010 1.00 98.37 ? 399 ASP A OD1 1 ATOM 3028 O OD2 . ASP A 1 368 ? -15.288 6.260 -87.052 1.00 104.82 ? 399 ASP A OD2 1 ATOM 3029 N N . GLN A 1 369 ? -15.789 2.659 -83.205 1.00 66.53 ? 400 GLN A N 1 ATOM 3030 C CA . GLN A 1 369 ? -16.808 2.163 -82.290 1.00 53.27 ? 400 GLN A CA 1 ATOM 3031 C C . GLN A 1 369 ? -16.159 1.585 -81.040 1.00 54.78 ? 400 GLN A C 1 ATOM 3032 O O . GLN A 1 369 ? -15.125 0.921 -81.120 1.00 57.20 ? 400 GLN A O 1 ATOM 3033 C CB . GLN A 1 369 ? -17.673 1.100 -82.968 1.00 56.42 ? 400 GLN A CB 1 ATOM 3034 C CG . GLN A 1 369 ? -18.306 1.542 -84.277 1.00 66.18 ? 400 GLN A CG 1 ATOM 3035 C CD . GLN A 1 369 ? -19.459 2.500 -84.072 1.00 72.74 ? 400 GLN A CD 1 ATOM 3036 O OE1 . GLN A 1 369 ? -20.245 2.353 -83.135 1.00 65.99 ? 400 GLN A OE1 1 ATOM 3037 N NE2 . GLN A 1 369 ? -19.567 3.493 -84.948 1.00 82.04 ? 400 GLN A NE2 1 ATOM 3038 N N . GLU A 1 370 ? -16.762 1.843 -79.885 1.00 54.24 ? 401 GLU A N 1 ATOM 3039 C CA . GLU A 1 370 ? -16.303 1.236 -78.642 1.00 52.97 ? 401 GLU A CA 1 ATOM 3040 C C . GLU A 1 370 ? -17.385 0.325 -78.080 1.00 54.44 ? 401 GLU A C 1 ATOM 3041 O O . GLU A 1 370 ? -18.128 0.711 -77.178 1.00 64.93 ? 401 GLU A O 1 ATOM 3042 C CB . GLU A 1 370 ? -15.919 2.303 -77.616 1.00 55.68 ? 401 GLU A CB 1 ATOM 3043 C CG . GLU A 1 370 ? -14.712 3.139 -78.010 1.00 66.20 ? 401 GLU A CG 1 ATOM 3044 C CD . GLU A 1 370 ? -14.211 4.005 -76.872 1.00 83.06 ? 401 GLU A CD 1 ATOM 3045 O OE1 . GLU A 1 370 ? -14.329 5.245 -76.969 1.00 76.69 ? 401 GLU A OE1 1 ATOM 3046 O OE2 . GLU A 1 370 ? -13.693 3.445 -75.881 1.00 70.36 ? 401 GLU A OE2 1 ATOM 3047 N N . TYR A 1 371 ? -17.470 -0.885 -78.627 1.00 45.57 ? 402 TYR A N 1 ATOM 3048 C CA . TYR A 1 371 ? -18.470 -1.857 -78.200 1.00 48.21 ? 402 TYR A CA 1 ATOM 3049 C C . TYR A 1 371 ? -18.216 -2.335 -76.776 1.00 51.34 ? 402 TYR A C 1 ATOM 3050 O O . TYR A 1 371 ? -17.080 -2.629 -76.405 1.00 49.74 ? 402 TYR A O 1 ATOM 3051 C CB . TYR A 1 371 ? -18.492 -3.058 -79.144 1.00 44.41 ? 402 TYR A CB 1 ATOM 3052 C CG . TYR A 1 371 ? -18.850 -2.715 -80.572 1.00 47.30 ? 402 TYR A CG 1 ATOM 3053 C CD1 . TYR A 1 371 ? -20.166 -2.476 -80.939 1.00 40.20 ? 402 TYR A CD1 1 ATOM 3054 C CD2 . TYR A 1 371 ? -17.873 -2.647 -81.557 1.00 46.28 ? 402 TYR A CD2 1 ATOM 3055 C CE1 . TYR A 1 371 ? -20.498 -2.169 -82.240 1.00 39.76 ? 402 TYR A CE1 1 ATOM 3056 C CE2 . TYR A 1 371 ? -18.197 -2.343 -82.862 1.00 47.37 ? 402 TYR A CE2 1 ATOM 3057 C CZ . TYR A 1 371 ? -19.511 -2.103 -83.199 1.00 45.51 ? 402 TYR A CZ 1 ATOM 3058 O OH . TYR A 1 371 ? -19.840 -1.798 -84.501 1.00 55.73 ? 402 TYR A OH 1 ATOM 3059 N N . SER A 1 372 ? -19.280 -2.413 -75.983 1.00 50.52 ? 403 SER A N 1 ATOM 3060 C CA . SER A 1 372 ? -19.189 -2.955 -74.633 1.00 50.31 ? 403 SER A CA 1 ATOM 3061 C C . SER A 1 372 ? -19.411 -4.462 -74.668 1.00 55.89 ? 403 SER A C 1 ATOM 3062 O O . SER A 1 372 ? -19.719 -5.021 -75.721 1.00 53.16 ? 403 SER A O 1 ATOM 3063 C CB . SER A 1 372 ? -20.212 -2.291 -73.711 1.00 49.48 ? 403 SER A CB 1 ATOM 3064 O OG . SER A 1 372 ? -21.536 -2.563 -74.144 1.00 49.29 ? 403 SER A OG 1 ATOM 3065 N N . PHE A 1 373 ? -19.252 -5.114 -73.520 1.00 54.09 ? 404 PHE A N 1 ATOM 3066 C CA . PHE A 1 373 ? -19.499 -6.548 -73.412 1.00 45.97 ? 404 PHE A CA 1 ATOM 3067 C C . PHE A 1 373 ? -20.941 -6.888 -73.777 1.00 51.70 ? 404 PHE A C 1 ATOM 3068 O O . PHE A 1 373 ? -21.206 -7.910 -74.410 1.00 55.04 ? 404 PHE A O 1 ATOM 3069 C CB . PHE A 1 373 ? -19.192 -7.044 -71.998 1.00 51.32 ? 404 PHE A CB 1 ATOM 3070 C CG . PHE A 1 373 ? -17.734 -7.290 -71.741 1.00 50.28 ? 404 PHE A CG 1 ATOM 3071 C CD1 . PHE A 1 373 ? -16.891 -6.249 -71.392 1.00 45.84 ? 404 PHE A CD1 1 ATOM 3072 C CD2 . PHE A 1 373 ? -17.208 -8.568 -71.838 1.00 50.40 ? 404 PHE A CD2 1 ATOM 3073 C CE1 . PHE A 1 373 ? -15.548 -6.476 -71.150 1.00 40.38 ? 404 PHE A CE1 1 ATOM 3074 C CE2 . PHE A 1 373 ? -15.866 -8.802 -71.597 1.00 53.32 ? 404 PHE A CE2 1 ATOM 3075 C CZ . PHE A 1 373 ? -15.036 -7.754 -71.253 1.00 52.13 ? 404 PHE A CZ 1 ATOM 3076 N N . LYS A 1 374 ? -21.866 -6.022 -73.374 1.00 57.55 ? 405 LYS A N 1 ATOM 3077 C CA . LYS A 1 374 ? -23.281 -6.210 -73.663 1.00 58.89 ? 405 LYS A CA 1 ATOM 3078 C C . LYS A 1 374 ? -23.540 -6.175 -75.168 1.00 58.62 ? 405 LYS A C 1 ATOM 3079 O O . LYS A 1 374 ? -24.292 -6.993 -75.698 1.00 60.35 ? 405 LYS A O 1 ATOM 3080 C CB . LYS A 1 374 ? -24.116 -5.137 -72.958 1.00 66.89 ? 405 LYS A CB 1 ATOM 3081 C CG . LYS A 1 374 ? -25.579 -5.506 -72.749 1.00 70.44 ? 405 LYS A CG 1 ATOM 3082 C CD . LYS A 1 374 ? -25.785 -6.232 -71.425 1.00 94.00 ? 405 LYS A CD 1 ATOM 3083 C CE . LYS A 1 374 ? -27.240 -6.643 -71.237 1.00 87.69 ? 405 LYS A CE 1 ATOM 3084 N NZ . LYS A 1 374 ? -28.168 -5.484 -71.345 1.00 77.44 ? 405 LYS A NZ 1 ATOM 3085 N N . GLN A 1 375 ? -22.905 -5.225 -75.850 1.00 59.21 ? 406 GLN A N 1 ATOM 3086 C CA . GLN A 1 375 ? -23.096 -5.036 -77.285 1.00 62.36 ? 406 GLN A CA 1 ATOM 3087 C C . GLN A 1 375 ? -22.360 -6.086 -78.115 1.00 58.37 ? 406 GLN A C 1 ATOM 3088 O O . GLN A 1 375 ? -22.800 -6.449 -79.207 1.00 57.45 ? 406 GLN A O 1 ATOM 3089 C CB . GLN A 1 375 ? -22.625 -3.643 -77.707 1.00 57.86 ? 406 GLN A CB 1 ATOM 3090 C CG . GLN A 1 375 ? -23.277 -2.494 -76.966 1.00 58.04 ? 406 GLN A CG 1 ATOM 3091 C CD . GLN A 1 375 ? -22.700 -1.153 -77.374 1.00 63.37 ? 406 GLN A CD 1 ATOM 3092 O OE1 . GLN A 1 375 ? -21.874 -0.579 -76.666 1.00 60.69 ? 406 GLN A OE1 1 ATOM 3093 N NE2 . GLN A 1 375 ? -23.127 -0.651 -78.527 1.00 62.90 ? 406 GLN A NE2 1 ATOM 3094 N N . PHE A 1 376 ? -21.235 -6.563 -77.593 1.00 49.53 ? 407 PHE A N 1 ATOM 3095 C CA . PHE A 1 376 ? -20.358 -7.451 -78.346 1.00 47.29 ? 407 PHE A CA 1 ATOM 3096 C C . PHE A 1 376 ? -20.863 -8.893 -78.353 1.00 57.81 ? 407 PHE A C 1 ATOM 3097 O O . PHE A 1 376 ? -20.793 -9.573 -79.374 1.00 57.97 ? 407 PHE A O 1 ATOM 3098 C CB . PHE A 1 376 ? -18.940 -7.393 -77.774 1.00 45.28 ? 407 PHE A CB 1 ATOM 3099 C CG . PHE A 1 376 ? -17.863 -7.666 -78.785 1.00 47.46 ? 407 PHE A CG 1 ATOM 3100 C CD1 . PHE A 1 376 ? -17.753 -6.888 -79.926 1.00 42.10 ? 407 PHE A CD1 1 ATOM 3101 C CD2 . PHE A 1 376 ? -16.945 -8.685 -78.585 1.00 51.80 ? 407 PHE A CD2 1 ATOM 3102 C CE1 . PHE A 1 376 ? -16.760 -7.131 -80.857 1.00 42.68 ? 407 PHE A CE1 1 ATOM 3103 C CE2 . PHE A 1 376 ? -15.948 -8.931 -79.512 1.00 46.54 ? 407 PHE A CE2 1 ATOM 3104 C CZ . PHE A 1 376 ? -15.856 -8.153 -80.649 1.00 47.42 ? 407 PHE A CZ 1 ATOM 3105 N N . LEU A 1 377 ? -21.378 -9.349 -77.214 1.00 61.09 ? 408 LEU A N 1 ATOM 3106 C CA . LEU A 1 377 ? -21.818 -10.734 -77.059 1.00 57.06 ? 408 LEU A CA 1 ATOM 3107 C C . LEU A 1 377 ? -22.897 -11.138 -78.062 1.00 58.76 ? 408 LEU A C 1 ATOM 3108 O O . LEU A 1 377 ? -23.919 -10.465 -78.196 1.00 60.00 ? 408 LEU A O 1 ATOM 3109 C CB . LEU A 1 377 ? -22.322 -10.968 -75.632 1.00 58.37 ? 408 LEU A CB 1 ATOM 3110 C CG . LEU A 1 377 ? -21.357 -11.653 -74.658 1.00 65.22 ? 408 LEU A CG 1 ATOM 3111 C CD1 . LEU A 1 377 ? -19.957 -11.060 -74.752 1.00 56.99 ? 408 LEU A CD1 1 ATOM 3112 C CD2 . LEU A 1 377 ? -21.885 -11.564 -73.232 1.00 60.00 ? 408 LEU A CD2 1 ATOM 3113 N N . TYR A 1 378 ? -22.637 -12.236 -78.770 1.00 63.16 ? 409 TYR A N 1 ATOM 3114 C CA . TYR A 1 378 ? -23.579 -12.848 -79.713 1.00 66.29 ? 409 TYR A CA 1 ATOM 3115 C C . TYR A 1 378 ? -23.956 -11.963 -80.901 1.00 62.81 ? 409 TYR A C 1 ATOM 3116 O O . TYR A 1 378 ? -24.901 -12.273 -81.626 1.00 67.54 ? 409 TYR A O 1 ATOM 3117 C CB . TYR A 1 378 ? -24.859 -13.277 -78.987 1.00 68.05 ? 409 TYR A CB 1 ATOM 3118 C CG . TYR A 1 378 ? -24.667 -14.418 -78.013 1.00 85.46 ? 409 TYR A CG 1 ATOM 3119 C CD1 . TYR A 1 378 ? -24.380 -15.701 -78.464 1.00 76.42 ? 409 TYR A CD1 1 ATOM 3120 C CD2 . TYR A 1 378 ? -24.786 -14.215 -76.643 1.00 72.18 ? 409 TYR A CD2 1 ATOM 3121 C CE1 . TYR A 1 378 ? -24.208 -16.749 -77.577 1.00 72.62 ? 409 TYR A CE1 1 ATOM 3122 C CE2 . TYR A 1 378 ? -24.616 -15.256 -75.749 1.00 79.97 ? 409 TYR A CE2 1 ATOM 3123 C CZ . TYR A 1 378 ? -24.328 -16.521 -76.222 1.00 90.76 ? 409 TYR A CZ 1 ATOM 3124 O OH . TYR A 1 378 ? -24.157 -17.560 -75.337 1.00 88.19 ? 409 TYR A OH 1 ATOM 3125 N N . ASN A 1 379 ? -23.220 -10.877 -81.113 1.00 53.91 ? 410 ASN A N 1 ATOM 3126 C CA . ASN A 1 379 ? -23.543 -9.966 -82.203 1.00 57.43 ? 410 ASN A CA 1 ATOM 3127 C C . ASN A 1 379 ? -22.674 -10.208 -83.436 1.00 56.25 ? 410 ASN A C 1 ATOM 3128 O O . ASN A 1 379 ? -21.661 -9.539 -83.637 1.00 58.46 ? 410 ASN A O 1 ATOM 3129 C CB . ASN A 1 379 ? -23.408 -8.512 -81.742 1.00 61.30 ? 410 ASN A CB 1 ATOM 3130 C CG . ASN A 1 379 ? -24.277 -7.564 -82.551 1.00 68.85 ? 410 ASN A CG 1 ATOM 3131 O OD1 . ASN A 1 379 ? -24.649 -7.865 -83.684 1.00 69.05 ? 410 ASN A OD1 1 ATOM 3132 N ND2 . ASN A 1 379 ? -24.605 -6.413 -81.970 1.00 74.71 ? 410 ASN A ND2 1 ATOM 3133 N N . ASN A 1 380 ? -23.083 -11.167 -84.262 1.00 54.35 ? 411 ASN A N 1 ATOM 3134 C CA . ASN A 1 380 ? -22.365 -11.486 -85.493 1.00 50.25 ? 411 ASN A CA 1 ATOM 3135 C C . ASN A 1 380 ? -22.565 -10.433 -86.578 1.00 55.46 ? 411 ASN A C 1 ATOM 3136 O O . ASN A 1 380 ? -21.845 -10.420 -87.577 1.00 64.12 ? 411 ASN A O 1 ATOM 3137 C CB . ASN A 1 380 ? -22.796 -12.854 -86.029 1.00 54.98 ? 411 ASN A CB 1 ATOM 3138 C CG . ASN A 1 380 ? -22.248 -14.005 -85.208 1.00 56.56 ? 411 ASN A CG 1 ATOM 3139 O OD1 . ASN A 1 380 ? -21.187 -13.897 -84.594 1.00 57.48 ? 411 ASN A OD1 1 ATOM 3140 N ND2 . ASN A 1 380 ? -22.971 -15.119 -85.199 1.00 56.75 ? 411 ASN A ND2 1 ATOM 3141 N N . SER A 1 381 ? -23.549 -9.559 -86.387 1.00 59.62 ? 412 SER A N 1 ATOM 3142 C CA . SER A 1 381 ? -23.813 -8.492 -87.345 1.00 58.97 ? 412 SER A CA 1 ATOM 3143 C C . SER A 1 381 ? -22.700 -7.452 -87.299 1.00 56.52 ? 412 SER A C 1 ATOM 3144 O O . SER A 1 381 ? -22.468 -6.731 -88.270 1.00 55.08 ? 412 SER A O 1 ATOM 3145 C CB . SER A 1 381 ? -25.170 -7.839 -87.071 1.00 54.15 ? 412 SER A CB 1 ATOM 3146 O OG . SER A 1 381 ? -25.250 -7.365 -85.740 1.00 70.94 ? 412 SER A OG 1 ATOM 3147 N N . ILE A 1 382 ? -22.015 -7.381 -86.160 1.00 51.50 ? 413 ILE A N 1 ATOM 3148 C CA . ILE A 1 382 ? -20.831 -6.544 -86.023 1.00 48.04 ? 413 ILE A CA 1 ATOM 3149 C C . ILE A 1 382 ? -19.754 -7.026 -86.990 1.00 47.24 ? 413 ILE A C 1 ATOM 3150 O O . ILE A 1 382 ? -19.035 -6.227 -87.591 1.00 45.66 ? 413 ILE A O 1 ATOM 3151 C CB . ILE A 1 382 ? -20.284 -6.563 -84.579 1.00 48.68 ? 413 ILE A CB 1 ATOM 3152 C CG1 . ILE A 1 382 ? -21.316 -5.984 -83.610 1.00 51.35 ? 413 ILE A CG1 1 ATOM 3153 C CG2 . ILE A 1 382 ? -18.977 -5.790 -84.480 1.00 43.46 ? 413 ILE A CG2 1 ATOM 3154 C CD1 . ILE A 1 382 ? -20.832 -5.904 -82.177 1.00 46.67 ? 413 ILE A CD1 1 ATOM 3155 N N . LEU A 1 383 ? -19.664 -8.343 -87.145 1.00 45.52 ? 414 LEU A N 1 ATOM 3156 C CA . LEU A 1 383 ? -18.669 -8.952 -88.015 1.00 44.30 ? 414 LEU A CA 1 ATOM 3157 C C . LEU A 1 383 ? -18.951 -8.652 -89.484 1.00 47.20 ? 414 LEU A C 1 ATOM 3158 O O . LEU A 1 383 ? -18.029 -8.398 -90.261 1.00 43.34 ? 414 LEU A O 1 ATOM 3159 C CB . LEU A 1 383 ? -18.621 -10.465 -87.792 1.00 46.71 ? 414 LEU A CB 1 ATOM 3160 C CG . LEU A 1 383 ? -17.409 -11.191 -88.377 1.00 42.43 ? 414 LEU A CG 1 ATOM 3161 C CD1 . LEU A 1 383 ? -16.143 -10.729 -87.677 1.00 44.45 ? 414 LEU A CD1 1 ATOM 3162 C CD2 . LEU A 1 383 ? -17.571 -12.698 -88.268 1.00 33.96 ? 414 LEU A CD2 1 ATOM 3163 N N . LEU A 1 384 ? -20.226 -8.680 -89.860 1.00 48.02 ? 415 LEU A N 1 ATOM 3164 C CA . LEU A 1 384 ? -20.619 -8.439 -91.246 1.00 45.94 ? 415 LEU A CA 1 ATOM 3165 C C . LEU A 1 384 ? -20.566 -6.959 -91.614 1.00 46.37 ? 415 LEU A C 1 ATOM 3166 O O . LEU A 1 384 ? -20.287 -6.610 -92.762 1.00 52.18 ? 415 LEU A O 1 ATOM 3167 C CB . LEU A 1 384 ? -22.023 -8.985 -91.509 1.00 51.56 ? 415 LEU A CB 1 ATOM 3168 C CG . LEU A 1 384 ? -22.159 -10.501 -91.651 1.00 47.60 ? 415 LEU A CG 1 ATOM 3169 C CD1 . LEU A 1 384 ? -23.562 -10.866 -92.096 1.00 60.71 ? 415 LEU A CD1 1 ATOM 3170 C CD2 . LEU A 1 384 ? -21.139 -11.030 -92.638 1.00 48.17 ? 415 LEU A CD2 1 ATOM 3171 N N . GLU A 1 385 ? -20.842 -6.093 -90.644 1.00 38.94 ? 416 GLU A N 1 ATOM 3172 C CA . GLU A 1 385 ? -20.822 -4.657 -90.886 1.00 45.70 ? 416 GLU A CA 1 ATOM 3173 C C . GLU A 1 385 ? -19.412 -4.169 -91.201 1.00 50.75 ? 416 GLU A C 1 ATOM 3174 O O . GLU A 1 385 ? -19.206 -3.412 -92.151 1.00 53.59 ? 416 GLU A O 1 ATOM 3175 C CB . GLU A 1 385 ? -21.378 -3.896 -89.682 1.00 49.87 ? 416 GLU A CB 1 ATOM 3176 C CG . GLU A 1 385 ? -21.425 -2.387 -89.882 1.00 56.08 ? 416 GLU A CG 1 ATOM 3177 C CD . GLU A 1 385 ? -21.866 -1.640 -88.638 1.00 75.78 ? 416 GLU A CD 1 ATOM 3178 O OE1 . GLU A 1 385 ? -22.082 -2.291 -87.594 1.00 67.41 ? 416 GLU A OE1 1 ATOM 3179 O OE2 . GLU A 1 385 ? -21.996 -0.399 -88.706 1.00 70.05 ? 416 GLU A OE2 1 ATOM 3180 N N . HIS A 1 386 ? -18.445 -4.610 -90.402 1.00 44.20 ? 417 HIS A N 1 ATOM 3181 C CA . HIS A 1 386 ? -17.067 -4.155 -90.544 1.00 41.30 ? 417 HIS A CA 1 ATOM 3182 C C . HIS A 1 386 ? -16.249 -5.034 -91.489 1.00 38.83 ? 417 HIS A C 1 ATOM 3183 O O . HIS A 1 386 ? -15.441 -4.530 -92.268 1.00 41.67 ? 417 HIS A O 1 ATOM 3184 C CB . HIS A 1 386 ? -16.386 -4.095 -89.175 1.00 40.14 ? 417 HIS A CB 1 ATOM 3185 C CG . HIS A 1 386 ? -16.997 -3.099 -88.241 1.00 43.57 ? 417 HIS A CG 1 ATOM 3186 N ND1 . HIS A 1 386 ? -16.747 -1.747 -88.329 1.00 46.42 ? 417 HIS A ND1 1 ATOM 3187 C CD2 . HIS A 1 386 ? -17.846 -3.258 -87.199 1.00 46.68 ? 417 HIS A CD2 1 ATOM 3188 C CE1 . HIS A 1 386 ? -17.418 -1.115 -87.382 1.00 53.02 ? 417 HIS A CE1 1 ATOM 3189 N NE2 . HIS A 1 386 ? -18.092 -2.010 -86.682 1.00 46.32 ? 417 HIS A NE2 1 ATOM 3190 N N . GLY A 1 387 ? -16.458 -6.345 -91.416 1.00 41.94 ? 418 GLY A N 1 ATOM 3191 C CA . GLY A 1 387 ? -15.690 -7.284 -92.216 1.00 34.20 ? 418 GLY A CA 1 ATOM 3192 C C . GLY A 1 387 ? -14.432 -7.727 -91.495 1.00 32.87 ? 418 GLY A C 1 ATOM 3193 O O . GLY A 1 387 ? -14.018 -7.101 -90.520 1.00 32.45 ? 418 GLY A O 1 ATOM 3194 N N . LEU A 1 388 ? -13.817 -8.805 -91.975 1.00 34.99 ? 419 LEU A N 1 ATOM 3195 C CA . LEU A 1 388 ? -12.630 -9.356 -91.324 1.00 34.22 ? 419 LEU A CA 1 ATOM 3196 C C . LEU A 1 388 ? -11.423 -8.428 -91.440 1.00 38.85 ? 419 LEU A C 1 ATOM 3197 O O . LEU A 1 388 ? -10.644 -8.301 -90.496 1.00 39.29 ? 419 LEU A O 1 ATOM 3198 C CB . LEU A 1 388 ? -12.279 -10.731 -91.903 1.00 30.45 ? 419 LEU A CB 1 ATOM 3199 C CG . LEU A 1 388 ? -13.230 -11.902 -91.638 1.00 32.72 ? 419 LEU A CG 1 ATOM 3200 C CD1 . LEU A 1 388 ? -12.459 -13.211 -91.608 1.00 29.02 ? 419 LEU A CD1 1 ATOM 3201 C CD2 . LEU A 1 388 ? -13.985 -11.709 -90.345 1.00 36.26 ? 419 LEU A CD2 1 ATOM 3202 N N . THR A 1 389 ? -11.268 -7.788 -92.597 1.00 35.62 ? 420 THR A N 1 ATOM 3203 C CA . THR A 1 389 ? -10.149 -6.876 -92.818 1.00 32.26 ? 420 THR A CA 1 ATOM 3204 C C . THR A 1 389 ? -10.143 -5.771 -91.769 1.00 40.58 ? 420 THR A C 1 ATOM 3205 O O . THR A 1 389 ? -9.096 -5.436 -91.209 1.00 40.28 ? 420 THR A O 1 ATOM 3206 C CB . THR A 1 389 ? -10.190 -6.240 -94.223 1.00 30.45 ? 420 THR A CB 1 ATOM 3207 O OG1 . THR A 1 389 ? -10.238 -7.268 -95.219 1.00 36.24 ? 420 THR A OG1 1 ATOM 3208 C CG2 . THR A 1 389 ? -8.958 -5.380 -94.452 1.00 21.86 ? 420 THR A CG2 1 ATOM 3209 N N . GLN A 1 390 ? -11.322 -5.221 -91.495 1.00 41.23 ? 421 GLN A N 1 ATOM 3210 C CA . GLN A 1 390 ? -11.460 -4.177 -90.490 1.00 42.93 ? 421 GLN A CA 1 ATOM 3211 C C . GLN A 1 390 ? -11.175 -4.727 -89.098 1.00 42.18 ? 421 GLN A C 1 ATOM 3212 O O . GLN A 1 390 ? -10.557 -4.058 -88.271 1.00 44.26 ? 421 GLN A O 1 ATOM 3213 C CB . GLN A 1 390 ? -12.858 -3.563 -90.539 1.00 48.46 ? 421 GLN A CB 1 ATOM 3214 C CG . GLN A 1 390 ? -12.987 -2.301 -89.712 1.00 63.12 ? 421 GLN A CG 1 ATOM 3215 C CD . GLN A 1 390 ? -11.998 -1.237 -90.140 1.00 79.64 ? 421 GLN A CD 1 ATOM 3216 O OE1 . GLN A 1 390 ? -11.193 -0.761 -89.338 1.00 65.85 ? 421 GLN A OE1 1 ATOM 3217 N NE2 . GLN A 1 390 ? -12.057 -0.852 -91.410 1.00 66.36 ? 421 GLN A NE2 1 ATOM 3218 N N . PHE A 1 391 ? -11.629 -5.951 -88.848 1.00 39.40 ? 422 PHE A N 1 ATOM 3219 C CA . PHE A 1 391 ? -11.396 -6.614 -87.570 1.00 40.71 ? 422 PHE A CA 1 ATOM 3220 C C . PHE A 1 391 ? -9.907 -6.793 -87.297 1.00 38.00 ? 422 PHE A C 1 ATOM 3221 O O . PHE A 1 391 ? -9.432 -6.513 -86.197 1.00 38.17 ? 422 PHE A O 1 ATOM 3222 C CB . PHE A 1 391 ? -12.100 -7.972 -87.535 1.00 35.53 ? 422 PHE A CB 1 ATOM 3223 C CG . PHE A 1 391 ? -13.420 -7.954 -86.817 1.00 40.05 ? 422 PHE A CG 1 ATOM 3224 C CD1 . PHE A 1 391 ? -14.475 -7.194 -87.293 1.00 40.88 ? 422 PHE A CD1 1 ATOM 3225 C CD2 . PHE A 1 391 ? -13.609 -8.710 -85.672 1.00 37.38 ? 422 PHE A CD2 1 ATOM 3226 C CE1 . PHE A 1 391 ? -15.689 -7.180 -86.635 1.00 40.06 ? 422 PHE A CE1 1 ATOM 3227 C CE2 . PHE A 1 391 ? -14.820 -8.701 -85.009 1.00 42.78 ? 422 PHE A CE2 1 ATOM 3228 C CZ . PHE A 1 391 ? -15.864 -7.936 -85.492 1.00 41.16 ? 422 PHE A CZ 1 ATOM 3229 N N . VAL A 1 392 ? -9.176 -7.254 -88.308 1.00 35.00 ? 423 VAL A N 1 ATOM 3230 C CA . VAL A 1 392 ? -7.742 -7.488 -88.175 1.00 33.01 ? 423 VAL A CA 1 ATOM 3231 C C . VAL A 1 392 ? -6.981 -6.187 -87.929 1.00 39.15 ? 423 VAL A C 1 ATOM 3232 O O . VAL A 1 392 ? -6.102 -6.132 -87.071 1.00 38.02 ? 423 VAL A O 1 ATOM 3233 C CB . VAL A 1 392 ? -7.171 -8.188 -89.425 1.00 29.39 ? 423 VAL A CB 1 ATOM 3234 C CG1 . VAL A 1 392 ? -5.661 -8.311 -89.326 1.00 33.91 ? 423 VAL A CG1 1 ATOM 3235 C CG2 . VAL A 1 392 ? -7.802 -9.558 -89.595 1.00 25.41 ? 423 VAL A CG2 1 ATOM 3236 N N . GLU A 1 393 ? -7.328 -5.143 -88.676 1.00 41.98 ? 424 GLU A N 1 ATOM 3237 C CA . GLU A 1 393 ? -6.683 -3.843 -88.518 1.00 39.12 ? 424 GLU A CA 1 ATOM 3238 C C . GLU A 1 393 ? -6.879 -3.286 -87.111 1.00 44.42 ? 424 GLU A C 1 ATOM 3239 O O . GLU A 1 393 ? -5.942 -2.770 -86.502 1.00 42.66 ? 424 GLU A O 1 ATOM 3240 C CB . GLU A 1 393 ? -7.218 -2.848 -89.550 1.00 36.46 ? 424 GLU A CB 1 ATOM 3241 C CG . GLU A 1 393 ? -6.781 -3.131 -90.977 1.00 50.25 ? 424 GLU A CG 1 ATOM 3242 C CD . GLU A 1 393 ? -7.420 -2.184 -91.976 1.00 60.95 ? 424 GLU A CD 1 ATOM 3243 O OE1 . GLU A 1 393 ? -7.086 -2.268 -93.177 1.00 51.74 ? 424 GLU A OE1 1 ATOM 3244 O OE2 . GLU A 1 393 ? -8.260 -1.356 -91.560 1.00 51.68 ? 424 GLU A OE2 1 ATOM 3245 N N . SER A 1 394 ? -8.101 -3.399 -86.600 1.00 38.74 ? 425 SER A N 1 ATOM 3246 C CA . SER A 1 394 ? -8.437 -2.851 -85.291 1.00 34.77 ? 425 SER A CA 1 ATOM 3247 C C . SER A 1 394 ? -7.861 -3.681 -84.147 1.00 38.64 ? 425 SER A C 1 ATOM 3248 O O . SER A 1 394 ? -7.295 -3.135 -83.200 1.00 42.46 ? 425 SER A O 1 ATOM 3249 C CB . SER A 1 394 ? -9.955 -2.740 -85.136 1.00 38.66 ? 425 SER A CB 1 ATOM 3250 O OG . SER A 1 394 ? -10.494 -1.800 -86.051 1.00 43.86 ? 425 SER A OG 1 ATOM 3251 N N . PHE A 1 395 ? -8.005 -4.999 -84.236 1.00 41.97 ? 426 PHE A N 1 ATOM 3252 C CA . PHE A 1 395 ? -7.576 -5.883 -83.155 1.00 37.20 ? 426 PHE A CA 1 ATOM 3253 C C . PHE A 1 395 ? -6.059 -5.999 -83.050 1.00 36.67 ? 426 PHE A C 1 ATOM 3254 O O . PHE A 1 395 ? -5.535 -6.313 -81.984 1.00 38.77 ? 426 PHE A O 1 ATOM 3255 C CB . PHE A 1 395 ? -8.191 -7.273 -83.328 1.00 34.42 ? 426 PHE A CB 1 ATOM 3256 C CG . PHE A 1 395 ? -9.620 -7.359 -82.875 1.00 39.59 ? 426 PHE A CG 1 ATOM 3257 C CD1 . PHE A 1 395 ? -10.169 -6.364 -82.084 1.00 41.51 ? 426 PHE A CD1 1 ATOM 3258 C CD2 . PHE A 1 395 ? -10.413 -8.437 -83.232 1.00 45.05 ? 426 PHE A CD2 1 ATOM 3259 C CE1 . PHE A 1 395 ? -11.481 -6.438 -81.661 1.00 47.62 ? 426 PHE A CE1 1 ATOM 3260 C CE2 . PHE A 1 395 ? -11.726 -8.517 -82.811 1.00 47.15 ? 426 PHE A CE2 1 ATOM 3261 C CZ . PHE A 1 395 ? -12.262 -7.516 -82.026 1.00 43.53 ? 426 PHE A CZ 1 ATOM 3262 N N . THR A 1 396 ? -5.357 -5.746 -84.151 1.00 31.79 ? 427 THR A N 1 ATOM 3263 C CA . THR A 1 396 ? -3.897 -5.778 -84.139 1.00 30.19 ? 427 THR A CA 1 ATOM 3264 C C . THR A 1 396 ? -3.350 -4.639 -83.279 1.00 34.38 ? 427 THR A C 1 ATOM 3265 O O . THR A 1 396 ? -2.250 -4.730 -82.735 1.00 34.66 ? 427 THR A O 1 ATOM 3266 C CB . THR A 1 396 ? -3.315 -5.679 -85.569 1.00 36.51 ? 427 THR A CB 1 ATOM 3267 O OG1 . THR A 1 396 ? -3.901 -6.690 -86.398 1.00 37.73 ? 427 THR A OG1 1 ATOM 3268 C CG2 . THR A 1 396 ? -1.802 -5.860 -85.564 1.00 35.18 ? 427 THR A CG2 1 ATOM 3269 N N . ARG A 1 397 ? -4.135 -3.576 -83.139 1.00 35.28 ? 428 ARG A N 1 ATOM 3270 C CA . ARG A 1 397 ? -3.675 -2.382 -82.437 1.00 35.51 ? 428 ARG A CA 1 ATOM 3271 C C . ARG A 1 397 ? -4.316 -2.175 -81.065 1.00 35.76 ? 428 ARG A C 1 ATOM 3272 O O . ARG A 1 397 ? -3.934 -1.256 -80.341 1.00 37.17 ? 428 ARG A O 1 ATOM 3273 C CB . ARG A 1 397 ? -3.915 -1.142 -83.303 1.00 31.86 ? 428 ARG A CB 1 ATOM 3274 C CG . ARG A 1 397 ? -3.088 -1.121 -84.574 1.00 35.79 ? 428 ARG A CG 1 ATOM 3275 C CD . ARG A 1 397 ? -1.617 -1.343 -84.265 1.00 30.59 ? 428 ARG A CD 1 ATOM 3276 N NE . ARG A 1 397 ? -0.843 -1.627 -85.468 1.00 41.40 ? 428 ARG A NE 1 ATOM 3277 C CZ . ARG A 1 397 ? 0.444 -1.958 -85.463 1.00 45.43 ? 428 ARG A CZ 1 ATOM 3278 N NH1 . ARG A 1 397 ? 1.101 -2.046 -84.315 1.00 39.89 ? 428 ARG A NH1 1 ATOM 3279 N NH2 . ARG A 1 397 ? 1.072 -2.202 -86.605 1.00 45.55 ? 428 ARG A NH2 1 ATOM 3280 N N . GLN A 1 398 ? -5.282 -3.014 -80.702 1.00 29.39 ? 429 GLN A N 1 ATOM 3281 C CA . GLN A 1 398 ? -5.877 -2.923 -79.369 1.00 34.35 ? 429 GLN A CA 1 ATOM 3282 C C . GLN A 1 398 ? -5.174 -3.853 -78.386 1.00 34.54 ? 429 GLN A C 1 ATOM 3283 O O . GLN A 1 398 ? -5.132 -5.065 -78.585 1.00 35.42 ? 429 GLN A O 1 ATOM 3284 C CB . GLN A 1 398 ? -7.372 -3.241 -79.401 1.00 30.37 ? 429 GLN A CB 1 ATOM 3285 C CG . GLN A 1 398 ? -7.990 -3.271 -78.010 1.00 30.22 ? 429 GLN A CG 1 ATOM 3286 C CD . GLN A 1 398 ? -9.504 -3.264 -78.023 1.00 35.01 ? 429 GLN A CD 1 ATOM 3287 O OE1 . GLN A 1 398 ? -10.132 -3.457 -79.063 1.00 41.68 ? 429 GLN A OE1 1 ATOM 3288 N NE2 . GLN A 1 398 ? -10.100 -3.038 -76.858 1.00 31.65 ? 429 GLN A NE2 1 ATOM 3289 N N . ILE A 1 399 ? -4.638 -3.276 -77.317 1.00 25.74 ? 430 ILE A N 1 ATOM 3290 C CA . ILE A 1 399 ? -3.837 -4.027 -76.359 1.00 30.09 ? 430 ILE A CA 1 ATOM 3291 C C . ILE A 1 399 ? -4.709 -4.795 -75.363 1.00 34.70 ? 430 ILE A C 1 ATOM 3292 O O . ILE A 1 399 ? -5.814 -4.367 -75.024 1.00 37.93 ? 430 ILE A O 1 ATOM 3293 C CB . ILE A 1 399 ? -2.869 -3.087 -75.595 1.00 31.65 ? 430 ILE A CB 1 ATOM 3294 C CG1 . ILE A 1 399 ? -1.751 -3.885 -74.921 1.00 24.71 ? 430 ILE A CG1 1 ATOM 3295 C CG2 . ILE A 1 399 ? -3.624 -2.206 -74.602 1.00 17.98 ? 430 ILE A CG2 1 ATOM 3296 C CD1 . ILE A 1 399 ? -0.671 -3.023 -74.337 1.00 31.63 ? 430 ILE A CD1 1 ATOM 3297 N N . ALA A 1 400 ? -4.210 -5.943 -74.915 1.00 39.26 ? 431 ALA A N 1 ATOM 3298 C CA . ALA A 1 400 ? -4.915 -6.767 -73.940 1.00 33.75 ? 431 ALA A CA 1 ATOM 3299 C C . ALA A 1 400 ? -4.385 -6.510 -72.536 1.00 34.86 ? 431 ALA A C 1 ATOM 3300 O O . ALA A 1 400 ? -3.391 -5.806 -72.358 1.00 38.90 ? 431 ALA A O 1 ATOM 3301 C CB . ALA A 1 400 ? -4.786 -8.237 -74.296 1.00 31.31 ? 431 ALA A CB 1 ATOM 3302 N N . GLY A 1 401 ? -5.046 -7.092 -71.542 1.00 29.40 ? 432 GLY A N 1 ATOM 3303 C CA . GLY A 1 401 ? -4.701 -6.846 -70.155 1.00 39.71 ? 432 GLY A CA 1 ATOM 3304 C C . GLY A 1 401 ? -3.597 -7.733 -69.612 1.00 37.55 ? 432 GLY A C 1 ATOM 3305 O O . GLY A 1 401 ? -3.346 -8.821 -70.129 1.00 43.90 ? 432 GLY A O 1 ATOM 3306 N N . ARG A 1 402 ? -2.936 -7.261 -68.560 1.00 30.88 ? 433 ARG A N 1 ATOM 3307 C CA . ARG A 1 402 ? -1.889 -8.029 -67.899 1.00 30.68 ? 433 ARG A CA 1 ATOM 3308 C C . ARG A 1 402 ? -2.509 -9.122 -67.031 1.00 40.54 ? 433 ARG A C 1 ATOM 3309 O O . ARG A 1 402 ? -3.351 -8.843 -66.174 1.00 40.98 ? 433 ARG A O 1 ATOM 3310 C CB . ARG A 1 402 ? -1.003 -7.113 -67.054 1.00 33.57 ? 433 ARG A CB 1 ATOM 3311 C CG . ARG A 1 402 ? 0.361 -7.693 -66.713 1.00 31.48 ? 433 ARG A CG 1 ATOM 3312 C CD . ARG A 1 402 ? 1.206 -6.683 -65.952 1.00 24.72 ? 433 ARG A CD 1 ATOM 3313 N NE . ARG A 1 402 ? 2.619 -7.050 -65.933 1.00 29.93 ? 433 ARG A NE 1 ATOM 3314 C CZ . ARG A 1 402 ? 3.584 -6.282 -65.440 1.00 31.63 ? 433 ARG A CZ 1 ATOM 3315 N NH1 . ARG A 1 402 ? 3.291 -5.099 -64.923 1.00 34.52 ? 433 ARG A NH1 1 ATOM 3316 N NH2 . ARG A 1 402 ? 4.844 -6.695 -65.468 1.00 33.21 ? 433 ARG A NH2 1 ATOM 3317 N N . VAL A 1 403 ? -2.095 -10.365 -67.261 1.00 40.25 ? 434 VAL A N 1 ATOM 3318 C CA . VAL A 1 403 ? -2.668 -11.507 -66.553 1.00 40.19 ? 434 VAL A CA 1 ATOM 3319 C C . VAL A 1 403 ? -2.205 -11.558 -65.100 1.00 41.42 ? 434 VAL A C 1 ATOM 3320 O O . VAL A 1 403 ? -3.024 -11.630 -64.184 1.00 43.89 ? 434 VAL A O 1 ATOM 3321 C CB . VAL A 1 403 ? -2.312 -12.831 -67.250 1.00 37.93 ? 434 VAL A CB 1 ATOM 3322 C CG1 . VAL A 1 403 ? -2.838 -14.012 -66.452 1.00 37.40 ? 434 VAL A CG1 1 ATOM 3323 C CG2 . VAL A 1 403 ? -2.871 -12.844 -68.664 1.00 30.67 ? 434 VAL A CG2 1 ATOM 3324 N N . ALA A 1 404 ? -0.893 -11.523 -64.892 1.00 33.18 ? 435 ALA A N 1 ATOM 3325 C CA . ALA A 1 404 ? -0.342 -11.464 -63.543 1.00 33.96 ? 435 ALA A CA 1 ATOM 3326 C C . ALA A 1 404 ? -0.372 -10.029 -63.020 1.00 39.68 ? 435 ALA A C 1 ATOM 3327 O O . ALA A 1 404 ? -0.752 -9.108 -63.743 1.00 38.24 ? 435 ALA A O 1 ATOM 3328 C CB . ALA A 1 404 ? 1.076 -12.014 -63.521 1.00 34.48 ? 435 ALA A CB 1 ATOM 3329 N N . GLY A 1 405 ? 0.027 -9.841 -61.765 1.00 34.78 ? 436 GLY A N 1 ATOM 3330 C CA . GLY A 1 405 ? 0.084 -8.511 -61.183 1.00 40.61 ? 436 GLY A CA 1 ATOM 3331 C C . GLY A 1 405 ? -1.101 -8.168 -60.300 1.00 41.20 ? 436 GLY A C 1 ATOM 3332 O O . GLY A 1 405 ? -1.002 -7.308 -59.424 1.00 41.52 ? 436 GLY A O 1 ATOM 3333 N N . GLY A 1 406 ? -2.230 -8.828 -60.539 1.00 39.89 ? 437 GLY A N 1 ATOM 3334 C CA . GLY A 1 406 ? -3.402 -8.662 -59.699 1.00 38.90 ? 437 GLY A CA 1 ATOM 3335 C C . GLY A 1 406 ? -4.298 -7.497 -60.069 1.00 46.26 ? 437 GLY A C 1 ATOM 3336 O O . GLY A 1 406 ? -3.890 -6.587 -60.793 1.00 48.26 ? 437 GLY A O 1 ATOM 3337 N N . ARG A 1 407 ? -5.529 -7.546 -59.564 1.00 44.17 ? 438 ARG A N 1 ATOM 3338 C CA . ARG A 1 407 ? -6.513 -6.476 -59.726 1.00 43.87 ? 438 ARG A CA 1 ATOM 3339 C C . ARG A 1 407 ? -6.726 -6.054 -61.177 1.00 45.10 ? 438 ARG A C 1 ATOM 3340 O O . ARG A 1 407 ? -6.701 -4.864 -61.492 1.00 51.08 ? 438 ARG A O 1 ATOM 3341 C CB . ARG A 1 407 ? -6.110 -5.254 -58.896 1.00 41.21 ? 438 ARG A CB 1 ATOM 3342 C CG . ARG A 1 407 ? -6.144 -5.484 -57.394 1.00 47.81 ? 438 ARG A CG 1 ATOM 3343 C CD . ARG A 1 407 ? -6.117 -4.170 -56.633 1.00 51.39 ? 438 ARG A CD 1 ATOM 3344 N NE . ARG A 1 407 ? -6.362 -4.362 -55.206 1.00 55.22 ? 438 ARG A NE 1 ATOM 3345 C CZ . ARG A 1 407 ? -5.530 -3.975 -54.245 1.00 53.81 ? 438 ARG A CZ 1 ATOM 3346 N NH1 . ARG A 1 407 ? -4.394 -3.365 -54.555 1.00 54.03 ? 438 ARG A NH1 1 ATOM 3347 N NH2 . ARG A 1 407 ? -5.836 -4.193 -52.974 1.00 56.09 ? 438 ARG A NH2 1 ATOM 3348 N N . ASN A 1 408 ? -6.947 -7.023 -62.058 1.00 44.67 ? 439 ASN A N 1 ATOM 3349 C CA . ASN A 1 408 ? -7.142 -6.712 -63.469 1.00 40.01 ? 439 ASN A CA 1 ATOM 3350 C C . ASN A 1 408 ? -8.215 -7.572 -64.133 1.00 42.32 ? 439 ASN A C 1 ATOM 3351 O O . ASN A 1 408 ? -8.325 -7.604 -65.360 1.00 35.94 ? 439 ASN A O 1 ATOM 3352 C CB . ASN A 1 408 ? -5.819 -6.856 -64.224 1.00 43.39 ? 439 ASN A CB 1 ATOM 3353 C CG . ASN A 1 408 ? -5.796 -6.057 -65.512 1.00 44.07 ? 439 ASN A CG 1 ATOM 3354 O OD1 . ASN A 1 408 ? -6.574 -5.118 -65.685 1.00 39.33 ? 439 ASN A OD1 1 ATOM 3355 N ND2 . ASN A 1 408 ? -4.906 -6.429 -66.424 1.00 38.42 ? 439 ASN A ND2 1 ATOM 3356 N N . VAL A 1 409 ? -9.007 -8.267 -63.324 1.00 41.40 ? 440 VAL A N 1 ATOM 3357 C CA . VAL A 1 409 ? -10.135 -9.028 -63.848 1.00 41.72 ? 440 VAL A CA 1 ATOM 3358 C C . VAL A 1 409 ? -11.321 -8.102 -64.083 1.00 39.97 ? 440 VAL A C 1 ATOM 3359 O O . VAL A 1 409 ? -11.835 -7.504 -63.138 1.00 43.50 ? 440 VAL A O 1 ATOM 3360 C CB . VAL A 1 409 ? -10.555 -10.169 -62.895 1.00 41.05 ? 440 VAL A CB 1 ATOM 3361 C CG1 . VAL A 1 409 ? -11.841 -10.822 -63.382 1.00 31.00 ? 440 VAL A CG1 1 ATOM 3362 C CG2 . VAL A 1 409 ? -9.443 -11.198 -62.771 1.00 39.76 ? 440 VAL A CG2 1 ATOM 3363 N N . PRO A 1 410 ? -11.750 -7.969 -65.349 1.00 41.92 ? 441 PRO A N 1 ATOM 3364 C CA . PRO A 1 410 ? -12.894 -7.117 -65.692 1.00 39.44 ? 441 PRO A CA 1 ATOM 3365 C C . PRO A 1 410 ? -14.145 -7.533 -64.929 1.00 42.92 ? 441 PRO A C 1 ATOM 3366 O O . PRO A 1 410 ? -14.402 -8.724 -64.770 1.00 48.31 ? 441 PRO A O 1 ATOM 3367 C CB . PRO A 1 410 ? -13.063 -7.330 -67.203 1.00 33.21 ? 441 PRO A CB 1 ATOM 3368 C CG . PRO A 1 410 ? -12.306 -8.577 -67.515 1.00 36.15 ? 441 PRO A CG 1 ATOM 3369 C CD . PRO A 1 410 ? -11.180 -8.629 -66.535 1.00 42.90 ? 441 PRO A CD 1 ATOM 3370 N N . ILE A 1 411 ? -14.906 -6.550 -64.460 1.00 47.89 ? 442 ILE A N 1 ATOM 3371 C CA . ILE A 1 411 ? -16.047 -6.802 -63.590 1.00 48.70 ? 442 ILE A CA 1 ATOM 3372 C C . ILE A 1 411 ? -17.197 -7.469 -64.348 1.00 48.25 ? 442 ILE A C 1 ATOM 3373 O O . ILE A 1 411 ? -18.112 -8.030 -63.745 1.00 53.76 ? 442 ILE A O 1 ATOM 3374 C CB . ILE A 1 411 ? -16.539 -5.489 -62.935 1.00 50.21 ? 442 ILE A CB 1 ATOM 3375 C CG1 . ILE A 1 411 ? -17.388 -5.780 -61.694 1.00 59.26 ? 442 ILE A CG1 1 ATOM 3376 C CG2 . ILE A 1 411 ? -17.288 -4.628 -63.944 1.00 62.15 ? 442 ILE A CG2 1 ATOM 3377 C CD1 . ILE A 1 411 ? -17.795 -4.541 -60.929 1.00 72.09 ? 442 ILE A CD1 1 ATOM 3378 N N . ALA A 1 412 ? -17.136 -7.421 -65.674 1.00 48.48 ? 443 ALA A N 1 ATOM 3379 C CA . ALA A 1 412 ? -18.164 -8.027 -66.512 1.00 46.75 ? 443 ALA A CA 1 ATOM 3380 C C . ALA A 1 412 ? -18.112 -9.554 -66.453 1.00 57.98 ? 443 ALA A C 1 ATOM 3381 O O . ALA A 1 412 ? -19.087 -10.227 -66.790 1.00 61.81 ? 443 ALA A O 1 ATOM 3382 C CB . ALA A 1 412 ? -18.023 -7.549 -67.950 1.00 42.26 ? 443 ALA A CB 1 ATOM 3383 N N . VAL A 1 413 ? -16.974 -10.097 -66.026 1.00 48.98 ? 444 VAL A N 1 ATOM 3384 C CA . VAL A 1 413 ? -16.802 -11.545 -65.951 1.00 46.85 ? 444 VAL A CA 1 ATOM 3385 C C . VAL A 1 413 ? -16.390 -12.010 -64.553 1.00 49.12 ? 444 VAL A C 1 ATOM 3386 O O . VAL A 1 413 ? -15.717 -13.032 -64.404 1.00 49.35 ? 444 VAL A O 1 ATOM 3387 C CB . VAL A 1 413 ? -15.756 -12.041 -66.971 1.00 46.95 ? 444 VAL A CB 1 ATOM 3388 C CG1 . VAL A 1 413 ? -16.239 -11.790 -68.391 1.00 48.53 ? 444 VAL A CG1 1 ATOM 3389 C CG2 . VAL A 1 413 ? -14.411 -11.367 -66.734 1.00 46.47 ? 444 VAL A CG2 1 ATOM 3390 N N . GLN A 1 414 ? -16.807 -11.267 -63.532 1.00 51.41 ? 445 GLN A N 1 ATOM 3391 C CA . GLN A 1 414 ? -16.455 -11.601 -62.154 1.00 49.93 ? 445 GLN A CA 1 ATOM 3392 C C . GLN A 1 414 ? -17.067 -12.931 -61.713 1.00 52.52 ? 445 GLN A C 1 ATOM 3393 O O . GLN A 1 414 ? -16.515 -13.620 -60.856 1.00 56.69 ? 445 GLN A O 1 ATOM 3394 C CB . GLN A 1 414 ? -16.892 -10.483 -61.202 1.00 52.08 ? 445 GLN A CB 1 ATOM 3395 C CG . GLN A 1 414 ? -18.387 -10.203 -61.201 1.00 62.16 ? 445 GLN A CG 1 ATOM 3396 C CD . GLN A 1 414 ? -18.796 -9.225 -60.117 1.00 73.80 ? 445 GLN A CD 1 ATOM 3397 O OE1 . GLN A 1 414 ? -18.026 -8.939 -59.200 1.00 74.55 ? 445 GLN A OE1 1 ATOM 3398 N NE2 . GLN A 1 414 ? -20.014 -8.706 -60.217 1.00 66.24 ? 445 GLN A NE2 1 ATOM 3399 N N . ALA A 1 415 ? -18.204 -13.289 -62.303 1.00 50.63 ? 446 ALA A N 1 ATOM 3400 C CA . ALA A 1 415 ? -18.870 -14.547 -61.982 1.00 48.24 ? 446 ALA A CA 1 ATOM 3401 C C . ALA A 1 415 ? -18.058 -15.732 -62.493 1.00 51.61 ? 446 ALA A C 1 ATOM 3402 O O . ALA A 1 415 ? -17.931 -16.751 -61.811 1.00 49.27 ? 446 ALA A O 1 ATOM 3403 C CB . ALA A 1 415 ? -20.278 -14.571 -62.566 1.00 34.13 ? 446 ALA A CB 1 ATOM 3404 N N . VAL A 1 416 ? -17.506 -15.590 -63.695 1.00 50.67 ? 447 VAL A N 1 ATOM 3405 C CA . VAL A 1 416 ? -16.683 -16.637 -64.291 1.00 48.22 ? 447 VAL A CA 1 ATOM 3406 C C . VAL A 1 416 ? -15.388 -16.817 -63.502 1.00 51.27 ? 447 VAL A C 1 ATOM 3407 O O . VAL A 1 416 ? -14.923 -17.940 -63.296 1.00 53.05 ? 447 VAL A O 1 ATOM 3408 C CB . VAL A 1 416 ? -16.347 -16.323 -65.764 1.00 43.39 ? 447 VAL A CB 1 ATOM 3409 C CG1 . VAL A 1 416 ? -15.621 -17.489 -66.403 1.00 37.91 ? 447 VAL A CG1 1 ATOM 3410 C CG2 . VAL A 1 416 ? -17.614 -16.001 -66.537 1.00 39.95 ? 447 VAL A CG2 1 ATOM 3411 N N . ALA A 1 417 ? -14.817 -15.702 -63.058 1.00 48.08 ? 448 ALA A N 1 ATOM 3412 C CA . ALA A 1 417 ? -13.586 -15.728 -62.278 1.00 48.00 ? 448 ALA A CA 1 ATOM 3413 C C . ALA A 1 417 ? -13.814 -16.372 -60.914 1.00 48.47 ? 448 ALA A C 1 ATOM 3414 O O . ALA A 1 417 ? -12.969 -17.121 -60.423 1.00 53.75 ? 448 ALA A O 1 ATOM 3415 C CB . ALA A 1 417 ? -13.033 -14.321 -62.116 1.00 44.58 ? 448 ALA A CB 1 ATOM 3416 N N . LYS A 1 418 ? -14.959 -16.077 -60.306 1.00 46.90 ? 449 LYS A N 1 ATOM 3417 C CA . LYS A 1 418 ? -15.312 -16.666 -59.020 1.00 46.53 ? 449 LYS A CA 1 ATOM 3418 C C . LYS A 1 418 ? -15.543 -18.167 -59.171 1.00 48.96 ? 449 LYS A C 1 ATOM 3419 O O . LYS A 1 418 ? -15.181 -18.955 -58.295 1.00 43.63 ? 449 LYS A O 1 ATOM 3420 C CB . LYS A 1 418 ? -16.554 -15.989 -58.437 1.00 42.01 ? 449 LYS A CB 1 ATOM 3421 C CG . LYS A 1 418 ? -16.956 -16.500 -57.061 1.00 45.89 ? 449 LYS A CG 1 ATOM 3422 C CD . LYS A 1 418 ? -18.140 -15.725 -56.507 1.00 49.20 ? 449 LYS A CD 1 ATOM 3423 C CE . LYS A 1 418 ? -18.588 -16.279 -55.163 1.00 46.48 ? 449 LYS A CE 1 ATOM 3424 N NZ . LYS A 1 418 ? -19.101 -17.674 -55.268 1.00 50.61 ? 449 LYS A NZ 1 ATOM 3425 N N . ALA A 1 419 ? -16.142 -18.552 -60.294 1.00 45.34 ? 450 ALA A N 1 ATOM 3426 C CA . ALA A 1 419 ? -16.388 -19.957 -60.593 1.00 39.06 ? 450 ALA A CA 1 ATOM 3427 C C . ALA A 1 419 ? -15.076 -20.726 -60.689 1.00 45.70 ? 450 ALA A C 1 ATOM 3428 O O . ALA A 1 419 ? -14.988 -21.875 -60.262 1.00 53.75 ? 450 ALA A O 1 ATOM 3429 C CB . ALA A 1 419 ? -17.182 -20.095 -61.883 1.00 33.65 ? 450 ALA A CB 1 ATOM 3430 N N . SER A 1 420 ? -14.056 -20.079 -61.246 1.00 44.38 ? 451 SER A N 1 ATOM 3431 C CA . SER A 1 420 ? -12.739 -20.691 -61.376 1.00 43.31 ? 451 SER A CA 1 ATOM 3432 C C . SER A 1 420 ? -12.124 -20.971 -60.011 1.00 43.86 ? 451 SER A C 1 ATOM 3433 O O . SER A 1 420 ? -11.366 -21.925 -59.851 1.00 48.35 ? 451 SER A O 1 ATOM 3434 C CB . SER A 1 420 ? -11.808 -19.796 -62.196 1.00 42.38 ? 451 SER A CB 1 ATOM 3435 O OG . SER A 1 420 ? -12.317 -19.603 -63.504 1.00 55.91 ? 451 SER A OG 1 ATOM 3436 N N . ILE A 1 421 ? -12.450 -20.135 -59.031 1.00 47.15 ? 452 ILE A N 1 ATOM 3437 C CA . ILE A 1 421 ? -11.972 -20.338 -57.669 1.00 48.59 ? 452 ILE A CA 1 ATOM 3438 C C . ILE A 1 421 ? -12.759 -21.450 -56.982 1.00 48.69 ? 452 ILE A C 1 ATOM 3439 O O . ILE A 1 421 ? -12.176 -22.353 -56.383 1.00 49.48 ? 452 ILE A O 1 ATOM 3440 C CB . ILE A 1 421 ? -12.071 -19.050 -56.828 1.00 42.74 ? 452 ILE A CB 1 ATOM 3441 C CG1 . ILE A 1 421 ? -11.180 -17.958 -57.420 1.00 43.65 ? 452 ILE A CG1 1 ATOM 3442 C CG2 . ILE A 1 421 ? -11.685 -19.324 -55.382 1.00 37.99 ? 452 ILE A CG2 1 ATOM 3443 C CD1 . ILE A 1 421 ? -11.130 -16.694 -56.591 1.00 35.52 ? 452 ILE A CD1 1 ATOM 3444 N N . ASP A 1 422 ? -14.084 -21.380 -57.081 1.00 43.72 ? 453 ASP A N 1 ATOM 3445 C CA . ASP A 1 422 ? -14.961 -22.361 -56.446 1.00 43.54 ? 453 ASP A CA 1 ATOM 3446 C C . ASP A 1 422 ? -14.750 -23.771 -56.998 1.00 48.34 ? 453 ASP A C 1 ATOM 3447 O O . ASP A 1 422 ? -14.602 -24.726 -56.234 1.00 42.67 ? 453 ASP A O 1 ATOM 3448 C CB . ASP A 1 422 ? -16.428 -21.954 -56.613 1.00 35.01 ? 453 ASP A CB 1 ATOM 3449 C CG . ASP A 1 422 ? -16.776 -20.694 -55.841 1.00 41.81 ? 453 ASP A CG 1 ATOM 3450 O OD1 . ASP A 1 422 ? -16.086 -20.396 -54.844 1.00 42.74 ? 453 ASP A OD1 1 ATOM 3451 O OD2 . ASP A 1 422 ? -17.744 -20.004 -56.227 1.00 39.67 ? 453 ASP A OD2 1 ATOM 3452 N N . GLN A 1 423 ? -14.741 -23.895 -58.323 1.00 50.70 ? 454 GLN A N 1 ATOM 3453 C CA . GLN A 1 423 ? -14.538 -25.188 -58.970 1.00 46.27 ? 454 GLN A CA 1 ATOM 3454 C C . GLN A 1 423 ? -13.150 -25.743 -58.666 1.00 44.22 ? 454 GLN A C 1 ATOM 3455 O O . GLN A 1 423 ? -12.957 -26.956 -58.597 1.00 43.36 ? 454 GLN A O 1 ATOM 3456 C CB . GLN A 1 423 ? -14.740 -25.070 -60.482 1.00 44.23 ? 454 GLN A CB 1 ATOM 3457 C CG . GLN A 1 423 ? -16.180 -24.809 -60.900 1.00 49.29 ? 454 GLN A CG 1 ATOM 3458 C CD . GLN A 1 423 ? -16.322 -24.608 -62.394 1.00 58.37 ? 454 GLN A CD 1 ATOM 3459 O OE1 . GLN A 1 423 ? -15.348 -24.316 -63.087 1.00 59.69 ? 454 GLN A OE1 1 ATOM 3460 N NE2 . GLN A 1 423 ? -17.539 -24.768 -62.900 1.00 68.95 ? 454 GLN A NE2 1 ATOM 3461 N N . SER A 1 424 ? -12.186 -24.847 -58.484 1.00 42.26 ? 455 SER A N 1 ATOM 3462 C CA . SER A 1 424 ? -10.837 -25.244 -58.115 1.00 37.37 ? 455 SER A CA 1 ATOM 3463 C C . SER A 1 424 ? -10.861 -25.938 -56.755 1.00 43.81 ? 455 SER A C 1 ATOM 3464 O O . SER A 1 424 ? -10.166 -26.933 -56.538 1.00 43.83 ? 455 SER A O 1 ATOM 3465 C CB . SER A 1 424 ? -9.909 -24.029 -58.088 1.00 47.18 ? 455 SER A CB 1 ATOM 3466 O OG . SER A 1 424 ? -8.547 -24.414 -58.036 1.00 61.09 ? 455 SER A OG 1 ATOM 3467 N N . ARG A 1 425 ? -11.679 -25.406 -55.848 1.00 48.43 ? 456 ARG A N 1 ATOM 3468 C CA . ARG A 1 425 ? -11.835 -25.969 -54.511 1.00 44.50 ? 456 ARG A CA 1 ATOM 3469 C C . ARG A 1 425 ? -12.677 -27.235 -54.551 1.00 43.76 ? 456 ARG A C 1 ATOM 3470 O O . ARG A 1 425 ? -12.421 -28.188 -53.815 1.00 47.26 ? 456 ARG A O 1 ATOM 3471 C CB . ARG A 1 425 ? -12.474 -24.950 -53.567 1.00 36.16 ? 456 ARG A CB 1 ATOM 3472 C CG . ARG A 1 425 ? -11.653 -23.697 -53.360 1.00 41.87 ? 456 ARG A CG 1 ATOM 3473 C CD . ARG A 1 425 ? -12.396 -22.685 -52.517 1.00 38.81 ? 456 ARG A CD 1 ATOM 3474 N NE . ARG A 1 425 ? -11.596 -21.486 -52.302 1.00 45.08 ? 456 ARG A NE 1 ATOM 3475 C CZ . ARG A 1 425 ? -12.014 -20.423 -51.625 1.00 44.92 ? 456 ARG A CZ 1 ATOM 3476 N NH1 . ARG A 1 425 ? -13.231 -20.410 -51.098 1.00 40.17 ? 456 ARG A NH1 1 ATOM 3477 N NH2 . ARG A 1 425 ? -11.218 -19.374 -51.477 1.00 45.26 ? 456 ARG A NH2 1 ATOM 3478 N N . GLU A 1 426 ? -13.687 -27.235 -55.414 1.00 40.93 ? 457 GLU A N 1 ATOM 3479 C CA . GLU A 1 426 ? -14.579 -28.378 -55.558 1.00 43.05 ? 457 GLU A CA 1 ATOM 3480 C C . GLU A 1 426 ? -13.822 -29.609 -56.055 1.00 40.01 ? 457 GLU A C 1 ATOM 3481 O O . GLU A 1 426 ? -14.116 -30.735 -55.654 1.00 39.90 ? 457 GLU A O 1 ATOM 3482 C CB . GLU A 1 426 ? -15.726 -28.034 -56.511 1.00 46.53 ? 457 GLU A CB 1 ATOM 3483 C CG . GLU A 1 426 ? -16.682 -29.179 -56.791 1.00 69.25 ? 457 GLU A CG 1 ATOM 3484 C CD . GLU A 1 426 ? -17.737 -28.812 -57.815 1.00 80.57 ? 457 GLU A CD 1 ATOM 3485 O OE1 . GLU A 1 426 ? -18.284 -29.731 -58.463 1.00 70.24 ? 457 GLU A OE1 1 ATOM 3486 O OE2 . GLU A 1 426 ? -18.020 -27.605 -57.971 1.00 64.47 ? 457 GLU A OE2 1 ATOM 3487 N N . MET A 1 427 ? -12.838 -29.384 -56.920 1.00 40.25 ? 458 MET A N 1 ATOM 3488 C CA . MET A 1 427 ? -12.017 -30.465 -57.456 1.00 36.37 ? 458 MET A CA 1 ATOM 3489 C C . MET A 1 427 ? -10.854 -30.792 -56.519 1.00 42.42 ? 458 MET A C 1 ATOM 3490 O O . MET A 1 427 ? -9.946 -31.550 -56.877 1.00 35.45 ? 458 MET A O 1 ATOM 3491 C CB . MET A 1 427 ? -11.497 -30.097 -58.848 1.00 36.52 ? 458 MET A CB 1 ATOM 3492 C CG . MET A 1 427 ? -12.597 -29.937 -59.889 1.00 38.95 ? 458 MET A CG 1 ATOM 3493 S SD . MET A 1 427 ? -11.969 -29.564 -61.535 1.00 42.60 ? 458 MET A SD 1 ATOM 3494 C CE . MET A 1 427 ? -11.183 -27.982 -61.245 1.00 37.05 ? 458 MET A CE 1 ATOM 3495 N N . LYS A 1 428 ? -10.896 -30.212 -55.321 1.00 36.82 ? 459 LYS A N 1 ATOM 3496 C CA . LYS A 1 428 ? -9.913 -30.469 -54.270 1.00 41.31 ? 459 LYS A CA 1 ATOM 3497 C C . LYS A 1 428 ? -8.465 -30.281 -54.725 1.00 39.84 ? 459 LYS A C 1 ATOM 3498 O O . LYS A 1 428 ? -7.625 -31.152 -54.503 1.00 37.01 ? 459 LYS A O 1 ATOM 3499 C CB . LYS A 1 428 ? -10.095 -31.886 -53.712 1.00 38.87 ? 459 LYS A CB 1 ATOM 3500 C CG . LYS A 1 428 ? -11.476 -32.152 -53.123 1.00 33.34 ? 459 LYS A CG 1 ATOM 3501 C CD . LYS A 1 428 ? -11.852 -31.110 -52.074 1.00 48.68 ? 459 LYS A CD 1 ATOM 3502 C CE . LYS A 1 428 ? -10.946 -31.179 -50.849 1.00 50.93 ? 459 LYS A CE 1 ATOM 3503 N NZ . LYS A 1 428 ? -11.160 -32.421 -50.055 1.00 55.29 ? 459 LYS A NZ 1 ATOM 3504 N N . TYR A 1 429 ? -8.180 -29.144 -55.357 1.00 39.21 ? 460 TYR A N 1 ATOM 3505 C CA . TYR A 1 429 ? -6.812 -28.806 -55.744 1.00 37.30 ? 460 TYR A CA 1 ATOM 3506 C C . TYR A 1 429 ? -5.919 -28.662 -54.518 1.00 33.83 ? 460 TYR A C 1 ATOM 3507 O O . TYR A 1 429 ? -6.346 -28.140 -53.488 1.00 43.86 ? 460 TYR A O 1 ATOM 3508 C CB . TYR A 1 429 ? -6.769 -27.502 -56.547 1.00 37.26 ? 460 TYR A CB 1 ATOM 3509 C CG . TYR A 1 429 ? -7.069 -27.638 -58.022 1.00 38.00 ? 460 TYR A CG 1 ATOM 3510 C CD1 . TYR A 1 429 ? -7.781 -28.725 -58.517 1.00 40.06 ? 460 TYR A CD1 1 ATOM 3511 C CD2 . TYR A 1 429 ? -6.629 -26.677 -58.925 1.00 35.67 ? 460 TYR A CD2 1 ATOM 3512 C CE1 . TYR A 1 429 ? -8.052 -28.844 -59.869 1.00 39.99 ? 460 TYR A CE1 1 ATOM 3513 C CE2 . TYR A 1 429 ? -6.895 -26.788 -60.274 1.00 32.22 ? 460 TYR A CE2 1 ATOM 3514 C CZ . TYR A 1 429 ? -7.605 -27.869 -60.742 1.00 37.94 ? 460 TYR A CZ 1 ATOM 3515 O OH . TYR A 1 429 ? -7.866 -27.973 -62.088 1.00 37.27 ? 460 TYR A OH 1 ATOM 3516 N N . GLN A 1 430 ? -4.676 -29.118 -54.633 1.00 33.55 ? 461 GLN A N 1 ATOM 3517 C CA . GLN A 1 430 ? -3.686 -28.868 -53.594 1.00 36.54 ? 461 GLN A CA 1 ATOM 3518 C C . GLN A 1 430 ? -3.247 -27.407 -53.651 1.00 40.90 ? 461 GLN A C 1 ATOM 3519 O O . GLN A 1 430 ? -3.593 -26.684 -54.587 1.00 36.54 ? 461 GLN A O 1 ATOM 3520 C CB . GLN A 1 430 ? -2.482 -29.800 -53.745 1.00 28.10 ? 461 GLN A CB 1 ATOM 3521 C CG . GLN A 1 430 ? -2.806 -31.272 -53.534 1.00 30.41 ? 461 GLN A CG 1 ATOM 3522 C CD . GLN A 1 430 ? -1.568 -32.147 -53.555 1.00 34.48 ? 461 GLN A CD 1 ATOM 3523 O OE1 . GLN A 1 430 ? -0.494 -31.730 -53.124 1.00 38.90 ? 461 GLN A OE1 1 ATOM 3524 N NE2 . GLN A 1 430 ? -1.709 -33.364 -54.067 1.00 37.42 ? 461 GLN A NE2 1 ATOM 3525 N N . SER A 1 431 ? -2.484 -26.976 -52.652 1.00 40.38 ? 462 SER A N 1 ATOM 3526 C CA . SER A 1 431 ? -2.098 -25.573 -52.529 1.00 38.27 ? 462 SER A CA 1 ATOM 3527 C C . SER A 1 431 ? -1.159 -25.121 -53.644 1.00 39.68 ? 462 SER A C 1 ATOM 3528 O O . SER A 1 431 ? -0.688 -25.932 -54.443 1.00 37.16 ? 462 SER A O 1 ATOM 3529 C CB . SER A 1 431 ? -1.439 -25.321 -51.172 1.00 40.39 ? 462 SER A CB 1 ATOM 3530 O OG . SER A 1 431 ? -0.179 -25.965 -51.089 1.00 47.88 ? 462 SER A OG 1 ATOM 3531 N N . LEU A 1 432 ? -0.898 -23.818 -53.687 1.00 37.81 ? 463 LEU A N 1 ATOM 3532 C CA . LEU A 1 432 ? 0.018 -23.235 -54.659 1.00 31.38 ? 463 LEU A CA 1 ATOM 3533 C C . LEU A 1 432 ? 1.430 -23.783 -54.501 1.00 36.73 ? 463 LEU A C 1 ATOM 3534 O O . LEU A 1 432 ? 2.064 -24.181 -55.479 1.00 45.03 ? 463 LEU A O 1 ATOM 3535 C CB . LEU A 1 432 ? 0.042 -21.711 -54.524 1.00 35.34 ? 463 LEU A CB 1 ATOM 3536 C CG . LEU A 1 432 ? 1.265 -21.003 -55.120 1.00 36.22 ? 463 LEU A CG 1 ATOM 3537 C CD1 . LEU A 1 432 ? 1.203 -20.966 -56.641 1.00 29.06 ? 463 LEU A CD1 1 ATOM 3538 C CD2 . LEU A 1 432 ? 1.418 -19.605 -54.545 1.00 31.72 ? 463 LEU A CD2 1 ATOM 3539 N N . ASN A 1 433 ? 1.920 -23.800 -53.265 1.00 40.02 ? 464 ASN A N 1 ATOM 3540 C CA . ASN A 1 433 ? 3.285 -24.235 -52.990 1.00 41.25 ? 464 ASN A CA 1 ATOM 3541 C C . ASN A 1 433 ? 3.506 -25.710 -53.296 1.00 37.99 ? 464 ASN A C 1 ATOM 3542 O O . ASN A 1 433 ? 4.626 -26.129 -53.584 1.00 40.08 ? 464 ASN A O 1 ATOM 3543 C CB . ASN A 1 433 ? 3.651 -23.943 -51.535 1.00 44.40 ? 464 ASN A CB 1 ATOM 3544 C CG . ASN A 1 433 ? 4.080 -22.506 -51.324 1.00 43.59 ? 464 ASN A CG 1 ATOM 3545 O OD1 . ASN A 1 433 ? 4.588 -21.859 -52.240 1.00 41.60 ? 464 ASN A OD1 1 ATOM 3546 N ND2 . ASN A 1 433 ? 3.882 -21.999 -50.113 1.00 50.57 ? 464 ASN A ND2 1 ATOM 3547 N N . GLU A 1 434 ? 2.438 -26.497 -53.238 1.00 37.07 ? 465 GLU A N 1 ATOM 3548 C CA . GLU A 1 434 ? 2.529 -27.903 -53.611 1.00 38.63 ? 465 GLU A CA 1 ATOM 3549 C C . GLU A 1 434 ? 2.705 -28.049 -55.119 1.00 40.69 ? 465 GLU A C 1 ATOM 3550 O O . GLU A 1 434 ? 3.446 -28.917 -55.584 1.00 42.88 ? 465 GLU A O 1 ATOM 3551 C CB . GLU A 1 434 ? 1.295 -28.671 -53.136 1.00 31.69 ? 465 GLU A CB 1 ATOM 3552 C CG . GLU A 1 434 ? 1.267 -28.904 -51.630 1.00 38.95 ? 465 GLU A CG 1 ATOM 3553 C CD . GLU A 1 434 ? 2.462 -29.705 -51.129 1.00 50.03 ? 465 GLU A CD 1 ATOM 3554 O OE1 . GLU A 1 434 ? 2.942 -30.601 -51.857 1.00 54.21 ? 465 GLU A OE1 1 ATOM 3555 O OE2 . GLU A 1 434 ? 2.924 -29.436 -50.000 1.00 57.73 ? 465 GLU A OE2 1 ATOM 3556 N N . TYR A 1 435 ? 2.034 -27.189 -55.881 1.00 33.61 ? 466 TYR A N 1 ATOM 3557 C CA . TYR A 1 435 ? 2.168 -27.205 -57.332 1.00 33.70 ? 466 TYR A CA 1 ATOM 3558 C C . TYR A 1 435 ? 3.497 -26.610 -57.776 1.00 38.37 ? 466 TYR A C 1 ATOM 3559 O O . TYR A 1 435 ? 4.053 -27.013 -58.796 1.00 41.92 ? 466 TYR A O 1 ATOM 3560 C CB . TYR A 1 435 ? 1.006 -26.462 -57.990 1.00 35.00 ? 466 TYR A CB 1 ATOM 3561 C CG . TYR A 1 435 ? -0.215 -27.330 -58.163 1.00 34.50 ? 466 TYR A CG 1 ATOM 3562 C CD1 . TYR A 1 435 ? -0.266 -28.290 -59.164 1.00 34.25 ? 466 TYR A CD1 1 ATOM 3563 C CD2 . TYR A 1 435 ? -1.311 -27.201 -57.321 1.00 31.43 ? 466 TYR A CD2 1 ATOM 3564 C CE1 . TYR A 1 435 ? -1.374 -29.095 -59.325 1.00 31.58 ? 466 TYR A CE1 1 ATOM 3565 C CE2 . TYR A 1 435 ? -2.425 -28.000 -57.475 1.00 30.59 ? 466 TYR A CE2 1 ATOM 3566 C CZ . TYR A 1 435 ? -2.452 -28.945 -58.479 1.00 29.74 ? 466 TYR A CZ 1 ATOM 3567 O OH . TYR A 1 435 ? -3.562 -29.742 -58.631 1.00 39.98 ? 466 TYR A OH 1 ATOM 3568 N N . ARG A 1 436 ? 4.008 -25.652 -57.010 1.00 32.86 ? 467 ARG A N 1 ATOM 3569 C CA . ARG A 1 436 ? 5.310 -25.075 -57.310 1.00 33.69 ? 467 ARG A CA 1 ATOM 3570 C C . ARG A 1 436 ? 6.401 -26.129 -57.143 1.00 39.35 ? 467 ARG A C 1 ATOM 3571 O O . ARG A 1 436 ? 7.276 -26.265 -57.996 1.00 41.28 ? 467 ARG A O 1 ATOM 3572 C CB . ARG A 1 436 ? 5.586 -23.858 -56.423 1.00 35.61 ? 467 ARG A CB 1 ATOM 3573 C CG . ARG A 1 436 ? 4.810 -22.614 -56.840 1.00 37.91 ? 467 ARG A CG 1 ATOM 3574 C CD . ARG A 1 436 ? 5.162 -21.406 -55.985 1.00 37.83 ? 467 ARG A CD 1 ATOM 3575 N NE . ARG A 1 436 ? 6.590 -21.103 -56.007 1.00 37.85 ? 467 ARG A NE 1 ATOM 3576 C CZ . ARG A 1 436 ? 7.179 -20.338 -56.920 1.00 40.51 ? 467 ARG A CZ 1 ATOM 3577 N NH1 . ARG A 1 436 ? 6.464 -19.797 -57.897 1.00 43.34 ? 467 ARG A NH1 1 ATOM 3578 N NH2 . ARG A 1 436 ? 8.485 -20.115 -56.860 1.00 41.81 ? 467 ARG A NH2 1 ATOM 3579 N N . LYS A 1 437 ? 6.333 -26.886 -56.051 1.00 39.53 ? 468 LYS A N 1 ATOM 3580 C CA . LYS A 1 437 ? 7.291 -27.962 -55.811 1.00 36.63 ? 468 LYS A CA 1 ATOM 3581 C C . LYS A 1 437 ? 7.163 -29.062 -56.860 1.00 38.06 ? 468 LYS A C 1 ATOM 3582 O O . LYS A 1 437 ? 8.159 -29.657 -57.272 1.00 38.40 ? 468 LYS A O 1 ATOM 3583 C CB . LYS A 1 437 ? 7.106 -28.548 -54.411 1.00 31.26 ? 468 LYS A CB 1 ATOM 3584 C CG . LYS A 1 437 ? 7.591 -27.635 -53.305 1.00 32.82 ? 468 LYS A CG 1 ATOM 3585 C CD . LYS A 1 437 ? 7.634 -28.344 -51.963 1.00 32.87 ? 468 LYS A CD 1 ATOM 3586 C CE . LYS A 1 437 ? 6.243 -28.662 -51.443 1.00 34.75 ? 468 LYS A CE 1 ATOM 3587 N NZ . LYS A 1 437 ? 6.305 -29.319 -50.106 1.00 38.08 ? 468 LYS A NZ 1 ATOM 3588 N N . ARG A 1 438 ? 5.931 -29.323 -57.284 1.00 43.37 ? 469 ARG A N 1 ATOM 3589 C CA . ARG A 1 438 ? 5.657 -30.314 -58.319 1.00 34.77 ? 469 ARG A CA 1 ATOM 3590 C C . ARG A 1 438 ? 6.391 -29.980 -59.616 1.00 37.23 ? 469 ARG A C 1 ATOM 3591 O O . ARG A 1 438 ? 6.849 -30.874 -60.329 1.00 32.87 ? 469 ARG A O 1 ATOM 3592 C CB . ARG A 1 438 ? 4.148 -30.413 -58.567 1.00 34.36 ? 469 ARG A CB 1 ATOM 3593 C CG . ARG A 1 438 ? 3.751 -31.182 -59.822 1.00 34.56 ? 469 ARG A CG 1 ATOM 3594 C CD . ARG A 1 438 ? 4.202 -32.632 -59.780 1.00 35.32 ? 469 ARG A CD 1 ATOM 3595 N NE . ARG A 1 438 ? 3.678 -33.388 -60.915 1.00 37.44 ? 469 ARG A NE 1 ATOM 3596 C CZ . ARG A 1 438 ? 4.249 -33.433 -62.115 1.00 34.80 ? 469 ARG A CZ 1 ATOM 3597 N NH1 . ARG A 1 438 ? 5.369 -32.761 -62.348 1.00 33.62 ? 469 ARG A NH1 1 ATOM 3598 N NH2 . ARG A 1 438 ? 3.696 -34.148 -63.085 1.00 37.21 ? 469 ARG A NH2 1 ATOM 3599 N N . PHE A 1 439 ? 6.512 -28.689 -59.909 1.00 41.87 ? 470 PHE A N 1 ATOM 3600 C CA . PHE A 1 439 ? 7.174 -28.251 -61.132 1.00 38.91 ? 470 PHE A CA 1 ATOM 3601 C C . PHE A 1 439 ? 8.533 -27.611 -60.842 1.00 44.10 ? 470 PHE A C 1 ATOM 3602 O O . PHE A 1 439 ? 8.955 -26.679 -61.531 1.00 36.98 ? 470 PHE A O 1 ATOM 3603 C CB . PHE A 1 439 ? 6.267 -27.293 -61.908 1.00 30.35 ? 470 PHE A CB 1 ATOM 3604 C CG . PHE A 1 439 ? 5.100 -27.979 -62.569 1.00 36.16 ? 470 PHE A CG 1 ATOM 3605 C CD1 . PHE A 1 439 ? 3.924 -28.204 -61.871 1.00 36.02 ? 470 PHE A CD1 1 ATOM 3606 C CD2 . PHE A 1 439 ? 5.189 -28.420 -63.880 1.00 29.98 ? 470 PHE A CD2 1 ATOM 3607 C CE1 . PHE A 1 439 ? 2.855 -28.845 -62.473 1.00 28.23 ? 470 PHE A CE1 1 ATOM 3608 C CE2 . PHE A 1 439 ? 4.124 -29.062 -64.486 1.00 26.96 ? 470 PHE A CE2 1 ATOM 3609 C CZ . PHE A 1 439 ? 2.956 -29.274 -63.781 1.00 30.95 ? 470 PHE A CZ 1 ATOM 3610 N N . SER A 1 440 ? 9.201 -28.129 -59.813 1.00 46.20 ? 471 SER A N 1 ATOM 3611 C CA . SER A 1 440 ? 10.589 -27.787 -59.491 1.00 41.47 ? 471 SER A CA 1 ATOM 3612 C C . SER A 1 440 ? 10.815 -26.319 -59.140 1.00 38.51 ? 471 SER A C 1 ATOM 3613 O O . SER A 1 440 ? 11.811 -25.722 -59.549 1.00 43.36 ? 471 SER A O 1 ATOM 3614 C CB . SER A 1 440 ? 11.503 -28.176 -60.655 1.00 42.30 ? 471 SER A CB 1 ATOM 3615 O OG . SER A 1 440 ? 11.416 -29.565 -60.917 1.00 44.43 ? 471 SER A OG 1 ATOM 3616 N N . LEU A 1 441 ? 9.899 -25.744 -58.368 1.00 33.42 ? 472 LEU A N 1 ATOM 3617 C CA . LEU A 1 441 ? 10.051 -24.369 -57.911 1.00 35.43 ? 472 LEU A CA 1 ATOM 3618 C C . LEU A 1 441 ? 10.147 -24.316 -56.391 1.00 43.48 ? 472 LEU A C 1 ATOM 3619 O O . LEU A 1 441 ? 9.568 -25.150 -55.694 1.00 49.40 ? 472 LEU A O 1 ATOM 3620 C CB . LEU A 1 441 ? 8.881 -23.506 -58.388 1.00 40.97 ? 472 LEU A CB 1 ATOM 3621 C CG . LEU A 1 441 ? 8.481 -23.617 -59.861 1.00 37.65 ? 472 LEU A CG 1 ATOM 3622 C CD1 . LEU A 1 441 ? 7.272 -22.741 -60.149 1.00 33.93 ? 472 LEU A CD1 1 ATOM 3623 C CD2 . LEU A 1 441 ? 9.641 -23.247 -60.766 1.00 36.80 ? 472 LEU A CD2 1 ATOM 3624 N N . LYS A 1 442 ? 10.886 -23.338 -55.877 1.00 40.84 ? 473 LYS A N 1 ATOM 3625 C CA . LYS A 1 442 ? 10.937 -23.118 -54.439 1.00 42.12 ? 473 LYS A CA 1 ATOM 3626 C C . LYS A 1 442 ? 9.607 -22.547 -53.968 1.00 40.10 ? 473 LYS A C 1 ATOM 3627 O O . LYS A 1 442 ? 9.066 -21.633 -54.590 1.00 43.05 ? 473 LYS A O 1 ATOM 3628 C CB . LYS A 1 442 ? 12.087 -22.178 -54.066 1.00 46.54 ? 473 LYS A CB 1 ATOM 3629 C CG . LYS A 1 442 ? 13.472 -22.763 -54.306 1.00 69.91 ? 473 LYS A CG 1 ATOM 3630 C CD . LYS A 1 442 ? 14.586 -21.753 -54.033 1.00 92.50 ? 473 LYS A CD 1 ATOM 3631 C CE . LYS A 1 442 ? 14.910 -21.623 -52.546 1.00 102.57 ? 473 LYS A CE 1 ATOM 3632 N NZ . LYS A 1 442 ? 13.902 -20.835 -51.778 1.00 87.99 ? 473 LYS A NZ 1 ATOM 3633 N N . PRO A 1 443 ? 9.062 -23.101 -52.877 1.00 40.57 ? 474 PRO A N 1 ATOM 3634 C CA . PRO A 1 443 ? 7.811 -22.580 -52.318 1.00 38.24 ? 474 PRO A CA 1 ATOM 3635 C C . PRO A 1 443 ? 7.958 -21.134 -51.856 1.00 43.12 ? 474 PRO A C 1 ATOM 3636 O O . PRO A 1 443 ? 9.053 -20.713 -51.486 1.00 48.18 ? 474 PRO A O 1 ATOM 3637 C CB . PRO A 1 443 ? 7.541 -23.508 -51.127 1.00 38.64 ? 474 PRO A CB 1 ATOM 3638 C CG . PRO A 1 443 ? 8.320 -24.744 -51.416 1.00 34.58 ? 474 PRO A CG 1 ATOM 3639 C CD . PRO A 1 443 ? 9.539 -24.292 -52.156 1.00 36.22 ? 474 PRO A CD 1 ATOM 3640 N N . TYR A 1 444 ? 6.864 -20.383 -51.888 1.00 42.48 ? 475 TYR A N 1 ATOM 3641 C CA . TYR A 1 444 ? 6.871 -19.017 -51.385 1.00 41.22 ? 475 TYR A CA 1 ATOM 3642 C C . TYR A 1 444 ? 6.815 -19.024 -49.861 1.00 49.09 ? 475 TYR A C 1 ATOM 3643 O O . TYR A 1 444 ? 5.977 -19.702 -49.264 1.00 50.05 ? 475 TYR A O 1 ATOM 3644 C CB . TYR A 1 444 ? 5.703 -18.222 -51.969 1.00 40.18 ? 475 TYR A CB 1 ATOM 3645 C CG . TYR A 1 444 ? 5.923 -17.789 -53.401 1.00 42.30 ? 475 TYR A CG 1 ATOM 3646 C CD1 . TYR A 1 444 ? 7.113 -17.184 -53.788 1.00 42.05 ? 475 TYR A CD1 1 ATOM 3647 C CD2 . TYR A 1 444 ? 4.946 -17.992 -54.368 1.00 41.38 ? 475 TYR A CD2 1 ATOM 3648 C CE1 . TYR A 1 444 ? 7.321 -16.787 -55.096 1.00 40.97 ? 475 TYR A CE1 1 ATOM 3649 C CE2 . TYR A 1 444 ? 5.148 -17.600 -55.681 1.00 38.19 ? 475 TYR A CE2 1 ATOM 3650 C CZ . TYR A 1 444 ? 6.336 -16.997 -56.037 1.00 41.31 ? 475 TYR A CZ 1 ATOM 3651 O OH . TYR A 1 444 ? 6.544 -16.602 -57.338 1.00 43.86 ? 475 TYR A OH 1 ATOM 3652 N N . THR A 1 445 ? 7.716 -18.273 -49.238 1.00 50.38 ? 476 THR A N 1 ATOM 3653 C CA . THR A 1 445 ? 7.828 -18.251 -47.783 1.00 47.46 ? 476 THR A CA 1 ATOM 3654 C C . THR A 1 445 ? 6.911 -17.206 -47.153 1.00 45.17 ? 476 THR A C 1 ATOM 3655 O O . THR A 1 445 ? 6.747 -17.170 -45.935 1.00 46.11 ? 476 THR A O 1 ATOM 3656 C CB . THR A 1 445 ? 9.277 -17.977 -47.343 1.00 43.83 ? 476 THR A CB 1 ATOM 3657 O OG1 . THR A 1 445 ? 9.715 -16.725 -47.884 1.00 50.41 ? 476 THR A OG1 1 ATOM 3658 C CG2 . THR A 1 445 ? 10.197 -19.082 -47.835 1.00 40.29 ? 476 THR A CG2 1 ATOM 3659 N N . SER A 1 446 ? 6.318 -16.362 -47.991 1.00 47.77 ? 477 SER A N 1 ATOM 3660 C CA . SER A 1 446 ? 5.423 -15.308 -47.525 1.00 44.41 ? 477 SER A CA 1 ATOM 3661 C C . SER A 1 446 ? 4.566 -14.774 -48.668 1.00 49.45 ? 477 SER A C 1 ATOM 3662 O O . SER A 1 446 ? 4.881 -14.982 -49.841 1.00 50.28 ? 477 SER A O 1 ATOM 3663 C CB . SER A 1 446 ? 6.220 -14.167 -46.894 1.00 44.40 ? 477 SER A CB 1 ATOM 3664 O OG . SER A 1 446 ? 7.071 -13.555 -47.848 1.00 45.64 ? 477 SER A OG 1 ATOM 3665 N N . PHE A 1 447 ? 3.485 -14.083 -48.321 1.00 44.88 ? 478 PHE A N 1 ATOM 3666 C CA . PHE A 1 447 ? 2.598 -13.501 -49.324 1.00 40.52 ? 478 PHE A CA 1 ATOM 3667 C C . PHE A 1 447 ? 3.259 -12.326 -50.036 1.00 46.77 ? 478 PHE A C 1 ATOM 3668 O O . PHE A 1 447 ? 2.893 -11.991 -51.163 1.00 47.33 ? 478 PHE A O 1 ATOM 3669 C CB . PHE A 1 447 ? 1.283 -13.050 -48.687 1.00 36.27 ? 478 PHE A CB 1 ATOM 3670 C CG . PHE A 1 447 ? 0.391 -14.184 -48.269 1.00 45.53 ? 478 PHE A CG 1 ATOM 3671 C CD1 . PHE A 1 447 ? -0.507 -14.740 -49.166 1.00 43.86 ? 478 PHE A CD1 1 ATOM 3672 C CD2 . PHE A 1 447 ? 0.446 -14.690 -46.981 1.00 42.50 ? 478 PHE A CD2 1 ATOM 3673 C CE1 . PHE A 1 447 ? -1.331 -15.781 -48.786 1.00 42.17 ? 478 PHE A CE1 1 ATOM 3674 C CE2 . PHE A 1 447 ? -0.377 -15.731 -46.597 1.00 47.29 ? 478 PHE A CE2 1 ATOM 3675 C CZ . PHE A 1 447 ? -1.265 -16.277 -47.499 1.00 45.65 ? 478 PHE A CZ 1 ATOM 3676 N N . GLU A 1 448 ? 4.228 -11.700 -49.376 1.00 51.55 ? 479 GLU A N 1 ATOM 3677 C CA . GLU A 1 448 ? 4.941 -10.575 -49.969 1.00 43.22 ? 479 GLU A CA 1 ATOM 3678 C C . GLU A 1 448 ? 5.905 -11.045 -51.050 1.00 46.42 ? 479 GLU A C 1 ATOM 3679 O O . GLU A 1 448 ? 6.106 -10.355 -52.047 1.00 54.14 ? 479 GLU A O 1 ATOM 3680 C CB . GLU A 1 448 ? 5.695 -9.781 -48.901 1.00 54.28 ? 479 GLU A CB 1 ATOM 3681 C CG . GLU A 1 448 ? 4.804 -8.913 -48.027 1.00 56.74 ? 479 GLU A CG 1 ATOM 3682 C CD . GLU A 1 448 ? 5.575 -7.826 -47.303 1.00 66.00 ? 479 GLU A CD 1 ATOM 3683 O OE1 . GLU A 1 448 ? 6.818 -7.789 -47.426 1.00 69.64 ? 479 GLU A OE1 1 ATOM 3684 O OE2 . GLU A 1 448 ? 4.935 -7.003 -46.614 1.00 57.66 ? 479 GLU A OE2 1 ATOM 3685 N N . GLU A 1 449 ? 6.502 -12.217 -50.849 1.00 45.81 ? 480 GLU A N 1 ATOM 3686 C CA . GLU A 1 449 ? 7.385 -12.799 -51.855 1.00 46.69 ? 480 GLU A CA 1 ATOM 3687 C C . GLU A 1 449 ? 6.580 -13.198 -53.091 1.00 48.60 ? 480 GLU A C 1 ATOM 3688 O O . GLU A 1 449 ? 7.094 -13.199 -54.210 1.00 46.52 ? 480 GLU A O 1 ATOM 3689 C CB . GLU A 1 449 ? 8.128 -14.012 -51.290 1.00 39.66 ? 480 GLU A CB 1 ATOM 3690 C CG . GLU A 1 449 ? 9.210 -14.559 -52.210 1.00 40.53 ? 480 GLU A CG 1 ATOM 3691 C CD . GLU A 1 449 ? 9.789 -15.874 -51.724 1.00 52.37 ? 480 GLU A CD 1 ATOM 3692 O OE1 . GLU A 1 449 ? 10.854 -16.280 -52.236 1.00 49.71 ? 480 GLU A OE1 1 ATOM 3693 O OE2 . GLU A 1 449 ? 9.179 -16.506 -50.837 1.00 59.20 ? 480 GLU A OE2 1 ATOM 3694 N N . LEU A 1 450 ? 5.311 -13.528 -52.874 1.00 42.75 ? 481 LEU A N 1 ATOM 3695 C CA . LEU A 1 450 ? 4.414 -13.920 -53.953 1.00 41.93 ? 481 LEU A CA 1 ATOM 3696 C C . LEU A 1 450 ? 4.015 -12.731 -54.825 1.00 46.20 ? 481 LEU A C 1 ATOM 3697 O O . LEU A 1 450 ? 4.153 -12.778 -56.048 1.00 47.23 ? 481 LEU A O 1 ATOM 3698 C CB . LEU A 1 450 ? 3.165 -14.594 -53.379 1.00 38.02 ? 481 LEU A CB 1 ATOM 3699 C CG . LEU A 1 450 ? 1.954 -14.753 -54.302 1.00 37.75 ? 481 LEU A CG 1 ATOM 3700 C CD1 . LEU A 1 450 ? 2.268 -15.660 -55.480 1.00 39.09 ? 481 LEU A CD1 1 ATOM 3701 C CD2 . LEU A 1 450 ? 0.754 -15.276 -53.526 1.00 36.41 ? 481 LEU A CD2 1 ATOM 3702 N N . THR A 1 451 ? 3.525 -11.667 -54.195 1.00 43.78 ? 482 THR A N 1 ATOM 3703 C CA . THR A 1 451 ? 2.999 -10.520 -54.930 1.00 44.71 ? 482 THR A CA 1 ATOM 3704 C C . THR A 1 451 ? 4.070 -9.491 -55.286 1.00 42.70 ? 482 THR A C 1 ATOM 3705 O O . THR A 1 451 ? 3.901 -8.709 -56.221 1.00 41.48 ? 482 THR A O 1 ATOM 3706 C CB . THR A 1 451 ? 1.891 -9.808 -54.133 1.00 41.67 ? 482 THR A CB 1 ATOM 3707 O OG1 . THR A 1 451 ? 2.457 -9.200 -52.965 1.00 42.39 ? 482 THR A OG1 1 ATOM 3708 C CG2 . THR A 1 451 ? 0.808 -10.794 -53.721 1.00 40.53 ? 482 THR A CG2 1 ATOM 3709 N N . GLY A 1 452 ? 5.165 -9.485 -54.534 1.00 41.93 ? 483 GLY A N 1 ATOM 3710 C CA . GLY A 1 452 ? 6.242 -8.540 -54.771 1.00 44.22 ? 483 GLY A CA 1 ATOM 3711 C C . GLY A 1 452 ? 5.919 -7.151 -54.253 1.00 52.93 ? 483 GLY A C 1 ATOM 3712 O O . GLY A 1 452 ? 6.683 -6.206 -54.453 1.00 51.55 ? 483 GLY A O 1 ATOM 3713 N N . GLU A 1 453 ? 4.776 -7.030 -53.586 1.00 49.22 ? 484 GLU A N 1 ATOM 3714 C CA . GLU A 1 453 ? 4.347 -5.762 -53.010 1.00 43.25 ? 484 GLU A CA 1 ATOM 3715 C C . GLU A 1 453 ? 3.802 -5.976 -51.599 1.00 49.76 ? 484 GLU A C 1 ATOM 3716 O O . GLU A 1 453 ? 3.966 -7.051 -51.024 1.00 56.28 ? 484 GLU A O 1 ATOM 3717 C CB . GLU A 1 453 ? 3.302 -5.095 -53.907 1.00 37.81 ? 484 GLU A CB 1 ATOM 3718 C CG . GLU A 1 453 ? 2.166 -6.007 -54.337 1.00 34.97 ? 484 GLU A CG 1 ATOM 3719 C CD . GLU A 1 453 ? 1.034 -6.049 -53.330 1.00 48.06 ? 484 GLU A CD 1 ATOM 3720 O OE1 . GLU A 1 453 ? 0.185 -5.134 -53.353 1.00 50.52 ? 484 GLU A OE1 1 ATOM 3721 O OE2 . GLU A 1 453 ? 0.992 -6.997 -52.517 1.00 51.18 ? 484 GLU A OE2 1 ATOM 3722 N N . LYS A 1 454 ? 3.154 -4.955 -51.044 1.00 50.59 ? 485 LYS A N 1 ATOM 3723 C CA . LYS A 1 454 ? 2.725 -5.004 -49.649 1.00 46.73 ? 485 LYS A CA 1 ATOM 3724 C C . LYS A 1 454 ? 1.209 -4.999 -49.474 1.00 48.76 ? 485 LYS A C 1 ATOM 3725 O O . LYS A 1 454 ? 0.676 -5.726 -48.637 1.00 53.73 ? 485 LYS A O 1 ATOM 3726 C CB . LYS A 1 454 ? 3.327 -3.829 -48.874 1.00 54.85 ? 485 LYS A CB 1 ATOM 3727 C CG . LYS A 1 454 ? 4.824 -3.932 -48.644 1.00 62.62 ? 485 LYS A CG 1 ATOM 3728 C CD . LYS A 1 454 ? 5.374 -2.670 -47.999 1.00 73.39 ? 485 LYS A CD 1 ATOM 3729 C CE . LYS A 1 454 ? 6.806 -2.867 -47.530 1.00 85.76 ? 485 LYS A CE 1 ATOM 3730 N NZ . LYS A 1 454 ? 6.893 -3.865 -46.425 1.00 83.88 ? 485 LYS A NZ 1 ATOM 3731 N N . GLU A 1 455 ? 0.520 -4.180 -50.261 1.00 50.37 ? 486 GLU A N 1 ATOM 3732 C CA . GLU A 1 455 ? -0.911 -3.959 -50.067 1.00 48.91 ? 486 GLU A CA 1 ATOM 3733 C C . GLU A 1 455 ? -1.756 -5.211 -50.312 1.00 53.23 ? 486 GLU A C 1 ATOM 3734 O O . GLU A 1 455 ? -2.583 -5.575 -49.476 1.00 48.62 ? 486 GLU A O 1 ATOM 3735 C CB . GLU A 1 455 ? -1.389 -2.819 -50.968 1.00 48.35 ? 486 GLU A CB 1 ATOM 3736 C CG . GLU A 1 455 ? -2.840 -2.425 -50.758 1.00 59.86 ? 486 GLU A CG 1 ATOM 3737 C CD . GLU A 1 455 ? -3.131 -1.015 -51.231 1.00 78.61 ? 486 GLU A CD 1 ATOM 3738 O OE1 . GLU A 1 455 ? -4.122 -0.824 -51.968 1.00 66.48 ? 486 GLU A OE1 1 ATOM 3739 O OE2 . GLU A 1 455 ? -2.370 -0.096 -50.857 1.00 67.04 ? 486 GLU A OE2 1 ATOM 3740 N N . MET A 1 456 ? -1.556 -5.863 -51.454 1.00 54.86 ? 487 MET A N 1 ATOM 3741 C CA . MET A 1 456 ? -2.306 -7.076 -51.774 1.00 54.40 ? 487 MET A CA 1 ATOM 3742 C C . MET A 1 456 ? -1.861 -8.251 -50.912 1.00 49.82 ? 487 MET A C 1 ATOM 3743 O O . MET A 1 456 ? -2.670 -9.107 -50.551 1.00 46.11 ? 487 MET A O 1 ATOM 3744 C CB . MET A 1 456 ? -2.159 -7.435 -53.254 1.00 42.37 ? 487 MET A CB 1 ATOM 3745 C CG . MET A 1 456 ? -2.898 -6.511 -54.199 1.00 47.24 ? 487 MET A CG 1 ATOM 3746 S SD . MET A 1 456 ? -2.769 -7.065 -55.908 1.00 49.23 ? 487 MET A SD 1 ATOM 3747 C CE . MET A 1 456 ? -0.996 -7.021 -56.142 1.00 29.80 ? 487 MET A CE 1 ATOM 3748 N N . ALA A 1 457 ? -0.572 -8.288 -50.590 1.00 41.28 ? 488 ALA A N 1 ATOM 3749 C CA . ALA A 1 457 ? -0.020 -9.347 -49.754 1.00 43.21 ? 488 ALA A CA 1 ATOM 3750 C C . ALA A 1 457 ? -0.663 -9.347 -48.372 1.00 51.41 ? 488 ALA A C 1 ATOM 3751 O O . ALA A 1 457 ? -0.945 -10.403 -47.806 1.00 51.96 ? 488 ALA A O 1 ATOM 3752 C CB . ALA A 1 457 ? 1.483 -9.194 -49.634 1.00 36.30 ? 488 ALA A CB 1 ATOM 3753 N N . ALA A 1 458 ? -0.893 -8.152 -47.838 1.00 52.83 ? 489 ALA A N 1 ATOM 3754 C CA . ALA A 1 458 ? -1.500 -7.999 -46.523 1.00 44.36 ? 489 ALA A CA 1 ATOM 3755 C C . ALA A 1 458 ? -2.955 -8.456 -46.525 1.00 47.89 ? 489 ALA A C 1 ATOM 3756 O O . ALA A 1 458 ? -3.426 -9.054 -45.558 1.00 58.36 ? 489 ALA A O 1 ATOM 3757 C CB . ALA A 1 458 ? -1.401 -6.559 -46.065 1.00 41.17 ? 489 ALA A CB 1 ATOM 3758 N N . GLU A 1 459 ? -3.662 -8.164 -47.613 1.00 43.79 ? 490 GLU A N 1 ATOM 3759 C CA . GLU A 1 459 ? -5.054 -8.573 -47.760 1.00 47.12 ? 490 GLU A CA 1 ATOM 3760 C C . GLU A 1 459 ? -5.166 -10.094 -47.810 1.00 55.93 ? 490 GLU A C 1 ATOM 3761 O O . GLU A 1 459 ? -6.100 -10.676 -47.256 1.00 59.79 ? 490 GLU A O 1 ATOM 3762 C CB . GLU A 1 459 ? -5.667 -7.958 -49.022 1.00 54.08 ? 490 GLU A CB 1 ATOM 3763 C CG . GLU A 1 459 ? -5.691 -6.436 -49.043 1.00 63.06 ? 490 GLU A CG 1 ATOM 3764 C CD . GLU A 1 459 ? -6.984 -5.860 -48.499 1.00 80.36 ? 490 GLU A CD 1 ATOM 3765 O OE1 . GLU A 1 459 ? -7.273 -4.677 -48.782 1.00 84.65 ? 490 GLU A OE1 1 ATOM 3766 O OE2 . GLU A 1 459 ? -7.714 -6.586 -47.792 1.00 75.35 ? 490 GLU A OE2 1 ATOM 3767 N N . LEU A 1 460 ? -4.205 -10.729 -48.474 1.00 52.43 ? 491 LEU A N 1 ATOM 3768 C CA . LEU A 1 460 ? -4.195 -12.181 -48.616 1.00 46.68 ? 491 LEU A CA 1 ATOM 3769 C C . LEU A 1 460 ? -3.843 -12.883 -47.308 1.00 48.86 ? 491 LEU A C 1 ATOM 3770 O O . LEU A 1 460 ? -4.394 -13.940 -46.998 1.00 51.66 ? 491 LEU A O 1 ATOM 3771 C CB . LEU A 1 460 ? -3.214 -12.601 -49.713 1.00 43.81 ? 491 LEU A CB 1 ATOM 3772 C CG . LEU A 1 460 ? -3.643 -12.320 -51.155 1.00 40.68 ? 491 LEU A CG 1 ATOM 3773 C CD1 . LEU A 1 460 ? -2.513 -12.631 -52.123 1.00 34.11 ? 491 LEU A CD1 1 ATOM 3774 C CD2 . LEU A 1 460 ? -4.893 -13.113 -51.513 1.00 29.02 ? 491 LEU A CD2 1 ATOM 3775 N N . LYS A 1 461 ? -2.923 -12.299 -46.546 1.00 45.20 ? 492 LYS A N 1 ATOM 3776 C CA . LYS A 1 461 ? -2.506 -12.885 -45.276 1.00 46.20 ? 492 LYS A CA 1 ATOM 3777 C C . LYS A 1 461 ? -3.643 -12.843 -44.259 1.00 48.47 ? 492 LYS A C 1 ATOM 3778 O O . LYS A 1 461 ? -3.744 -13.703 -43.386 1.00 52.52 ? 492 LYS A O 1 ATOM 3779 C CB . LYS A 1 461 ? -1.273 -12.166 -44.724 1.00 45.37 ? 492 LYS A CB 1 ATOM 3780 C CG . LYS A 1 461 ? -0.724 -12.787 -43.447 1.00 49.50 ? 492 LYS A CG 1 ATOM 3781 C CD . LYS A 1 461 ? 0.664 -12.266 -43.118 1.00 58.29 ? 492 LYS A CD 1 ATOM 3782 C CE . LYS A 1 461 ? 1.192 -12.904 -41.844 1.00 65.21 ? 492 LYS A CE 1 ATOM 3783 N NZ . LYS A 1 461 ? 1.163 -14.392 -41.915 1.00 63.96 ? 492 LYS A NZ 1 ATOM 3784 N N . ALA A 1 462 ? -4.503 -11.839 -44.383 1.00 45.16 ? 493 ALA A N 1 ATOM 3785 C CA . ALA A 1 462 ? -5.661 -11.719 -43.508 1.00 43.75 ? 493 ALA A CA 1 ATOM 3786 C C . ALA A 1 462 ? -6.713 -12.771 -43.848 1.00 50.40 ? 493 ALA A C 1 ATOM 3787 O O . ALA A 1 462 ? -7.506 -13.169 -42.994 1.00 58.77 ? 493 ALA A O 1 ATOM 3788 C CB . ALA A 1 462 ? -6.253 -10.325 -43.607 1.00 41.53 ? 493 ALA A CB 1 ATOM 3789 N N . LEU A 1 463 ? -6.706 -13.220 -45.100 1.00 52.86 ? 494 LEU A N 1 ATOM 3790 C CA . LEU A 1 463 ? -7.688 -14.182 -45.588 1.00 52.16 ? 494 LEU A CA 1 ATOM 3791 C C . LEU A 1 463 ? -7.211 -15.630 -45.457 1.00 53.01 ? 494 LEU A C 1 ATOM 3792 O O . LEU A 1 463 ? -8.009 -16.528 -45.177 1.00 52.65 ? 494 LEU A O 1 ATOM 3793 C CB . LEU A 1 463 ? -8.031 -13.888 -47.051 1.00 48.81 ? 494 LEU A CB 1 ATOM 3794 C CG . LEU A 1 463 ? -8.796 -12.607 -47.376 1.00 44.81 ? 494 LEU A CG 1 ATOM 3795 C CD1 . LEU A 1 463 ? -8.705 -12.307 -48.861 1.00 42.19 ? 494 LEU A CD1 1 ATOM 3796 C CD2 . LEU A 1 463 ? -10.249 -12.732 -46.951 1.00 46.28 ? 494 LEU A CD2 1 ATOM 3797 N N . TYR A 1 464 ? -5.915 -15.853 -45.662 1.00 43.87 ? 495 TYR A N 1 ATOM 3798 C CA . TYR A 1 464 ? -5.373 -17.209 -45.722 1.00 46.95 ? 495 TYR A CA 1 ATOM 3799 C C . TYR A 1 464 ? -4.514 -17.589 -44.518 1.00 54.82 ? 495 TYR A C 1 ATOM 3800 O O . TYR A 1 464 ? -4.346 -18.774 -44.227 1.00 51.82 ? 495 TYR A O 1 ATOM 3801 C CB . TYR A 1 464 ? -4.545 -17.385 -46.996 1.00 46.41 ? 495 TYR A CB 1 ATOM 3802 C CG . TYR A 1 464 ? -5.360 -17.495 -48.263 1.00 48.82 ? 495 TYR A CG 1 ATOM 3803 C CD1 . TYR A 1 464 ? -5.823 -18.726 -48.706 1.00 50.57 ? 495 TYR A CD1 1 ATOM 3804 C CD2 . TYR A 1 464 ? -5.657 -16.371 -49.021 1.00 48.81 ? 495 TYR A CD2 1 ATOM 3805 C CE1 . TYR A 1 464 ? -6.564 -18.835 -49.865 1.00 52.97 ? 495 TYR A CE1 1 ATOM 3806 C CE2 . TYR A 1 464 ? -6.400 -16.470 -50.183 1.00 50.25 ? 495 TYR A CE2 1 ATOM 3807 C CZ . TYR A 1 464 ? -6.850 -17.704 -50.600 1.00 54.52 ? 495 TYR A CZ 1 ATOM 3808 O OH . TYR A 1 464 ? -7.590 -17.810 -51.756 1.00 47.05 ? 495 TYR A OH 1 ATOM 3809 N N . SER A 1 465 ? -3.960 -16.579 -43.847 1.00 57.80 ? 496 SER A N 1 ATOM 3810 C CA . SER A 1 465 ? -3.093 -16.752 -42.674 1.00 49.93 ? 496 SER A CA 1 ATOM 3811 C C . SER A 1 465 ? -1.750 -17.401 -43.016 1.00 52.57 ? 496 SER A C 1 ATOM 3812 O O . SER A 1 465 ? -0.693 -16.851 -42.706 1.00 58.20 ? 496 SER A O 1 ATOM 3813 C CB . SER A 1 465 ? -3.799 -17.569 -41.587 1.00 49.42 ? 496 SER A CB 1 ATOM 3814 O OG . SER A 1 465 ? -5.085 -17.044 -41.300 1.00 55.55 ? 496 SER A OG 1 ATOM 3815 N N . ASP A 1 466 ? -1.791 -18.570 -43.648 1.00 45.96 ? 497 ASP A N 1 ATOM 3816 C CA . ASP A 1 466 ? -0.572 -19.300 -43.989 1.00 49.21 ? 497 ASP A CA 1 ATOM 3817 C C . ASP A 1 466 ? -0.329 -19.290 -45.501 1.00 54.82 ? 497 ASP A C 1 ATOM 3818 O O . ASP A 1 466 ? -1.253 -19.505 -46.288 1.00 54.97 ? 497 ASP A O 1 ATOM 3819 C CB . ASP A 1 466 ? -0.658 -20.740 -43.471 1.00 50.12 ? 497 ASP A CB 1 ATOM 3820 C CG . ASP A 1 466 ? 0.686 -21.449 -43.469 1.00 59.07 ? 497 ASP A CG 1 ATOM 3821 O OD1 . ASP A 1 466 ? 1.668 -20.894 -44.011 1.00 62.19 ? 497 ASP A OD1 1 ATOM 3822 O OD2 . ASP A 1 466 ? 0.758 -22.574 -42.927 1.00 58.70 ? 497 ASP A OD2 1 ATOM 3823 N N . ILE A 1 467 ? 0.916 -19.042 -45.900 1.00 47.73 ? 498 ILE A N 1 ATOM 3824 C CA . ILE A 1 467 ? 1.279 -18.998 -47.312 1.00 44.46 ? 498 ILE A CA 1 ATOM 3825 C C . ILE A 1 467 ? 1.162 -20.385 -47.949 1.00 49.70 ? 498 ILE A C 1 ATOM 3826 O O . ILE A 1 467 ? 0.924 -20.511 -49.152 1.00 51.28 ? 498 ILE A O 1 ATOM 3827 C CB . ILE A 1 467 ? 2.714 -18.442 -47.505 1.00 43.60 ? 498 ILE A CB 1 ATOM 3828 C CG1 . ILE A 1 467 ? 3.052 -18.289 -48.993 1.00 43.50 ? 498 ILE A CG1 1 ATOM 3829 C CG2 . ILE A 1 467 ? 3.737 -19.318 -46.801 1.00 43.65 ? 498 ILE A CG2 1 ATOM 3830 C CD1 . ILE A 1 467 ? 2.131 -17.352 -49.741 1.00 37.52 ? 498 ILE A CD1 1 ATOM 3831 N N . ASP A 1 468 ? 1.298 -21.425 -47.132 1.00 49.85 ? 499 ASP A N 1 ATOM 3832 C CA . ASP A 1 468 ? 1.210 -22.800 -47.617 1.00 45.41 ? 499 ASP A CA 1 ATOM 3833 C C . ASP A 1 468 ? -0.236 -23.239 -47.852 1.00 47.31 ? 499 ASP A C 1 ATOM 3834 O O . ASP A 1 468 ? -0.494 -24.398 -48.172 1.00 49.26 ? 499 ASP A O 1 ATOM 3835 C CB . ASP A 1 468 ? 1.887 -23.758 -46.634 1.00 42.52 ? 499 ASP A CB 1 ATOM 3836 C CG . ASP A 1 468 ? 3.398 -23.611 -46.621 1.00 52.45 ? 499 ASP A CG 1 ATOM 3837 O OD1 . ASP A 1 468 ? 3.976 -23.271 -47.675 1.00 51.52 ? 499 ASP A OD1 1 ATOM 3838 O OD2 . ASP A 1 468 ? 4.010 -23.841 -45.557 1.00 58.37 ? 499 ASP A OD2 1 ATOM 3839 N N . VAL A 1 469 ? -1.172 -22.308 -47.693 1.00 44.29 ? 500 VAL A N 1 ATOM 3840 C CA . VAL A 1 469 ? -2.591 -22.589 -47.893 1.00 46.35 ? 500 VAL A CA 1 ATOM 3841 C C . VAL A 1 469 ? -3.121 -21.805 -49.101 1.00 49.53 ? 500 VAL A C 1 ATOM 3842 O O . VAL A 1 469 ? -4.229 -22.052 -49.582 1.00 47.75 ? 500 VAL A O 1 ATOM 3843 C CB . VAL A 1 469 ? -3.406 -22.250 -46.621 1.00 50.15 ? 500 VAL A CB 1 ATOM 3844 C CG1 . VAL A 1 469 ? -4.848 -22.727 -46.737 1.00 50.48 ? 500 VAL A CG1 1 ATOM 3845 C CG2 . VAL A 1 469 ? -2.759 -22.888 -45.407 1.00 55.10 ? 500 VAL A CG2 1 ATOM 3846 N N . MET A 1 470 ? -2.311 -20.875 -49.602 1.00 45.13 ? 501 MET A N 1 ATOM 3847 C CA . MET A 1 470 ? -2.693 -20.059 -50.754 1.00 47.00 ? 501 MET A CA 1 ATOM 3848 C C . MET A 1 470 ? -3.056 -20.924 -51.961 1.00 43.01 ? 501 MET A C 1 ATOM 3849 O O . MET A 1 470 ? -2.318 -21.839 -52.324 1.00 43.04 ? 501 MET A O 1 ATOM 3850 C CB . MET A 1 470 ? -1.564 -19.092 -51.120 1.00 45.91 ? 501 MET A CB 1 ATOM 3851 C CG . MET A 1 470 ? -1.891 -18.167 -52.283 1.00 35.41 ? 501 MET A CG 1 ATOM 3852 S SD . MET A 1 470 ? -3.374 -17.186 -51.984 1.00 43.75 ? 501 MET A SD 1 ATOM 3853 C CE . MET A 1 470 ? -3.450 -16.222 -53.492 1.00 38.54 ? 501 MET A CE 1 ATOM 3854 N N . GLU A 1 471 ? -4.200 -20.627 -52.570 1.00 39.20 ? 502 GLU A N 1 ATOM 3855 C CA . GLU A 1 471 ? -4.711 -21.409 -53.692 1.00 37.12 ? 502 GLU A CA 1 ATOM 3856 C C . GLU A 1 471 ? -3.972 -21.092 -54.987 1.00 36.92 ? 502 GLU A C 1 ATOM 3857 O O . GLU A 1 471 ? -3.375 -20.028 -55.124 1.00 40.10 ? 502 GLU A O 1 ATOM 3858 C CB . GLU A 1 471 ? -6.209 -21.160 -53.869 1.00 37.17 ? 502 GLU A CB 1 ATOM 3859 C CG . GLU A 1 471 ? -7.014 -21.342 -52.598 1.00 34.07 ? 502 GLU A CG 1 ATOM 3860 C CD . GLU A 1 471 ? -8.486 -21.063 -52.800 1.00 47.87 ? 502 GLU A CD 1 ATOM 3861 O OE1 . GLU A 1 471 ? -9.104 -21.725 -53.660 1.00 48.60 ? 502 GLU A OE1 1 ATOM 3862 O OE2 . GLU A 1 471 ? -9.025 -20.179 -52.102 1.00 51.11 ? 502 GLU A OE2 1 ATOM 3863 N N . LEU A 1 472 ? -4.029 -22.019 -55.939 1.00 41.27 ? 503 LEU A N 1 ATOM 3864 C CA . LEU A 1 472 ? -3.274 -21.903 -57.186 1.00 38.75 ? 503 LEU A CA 1 ATOM 3865 C C . LEU A 1 472 ? -3.780 -20.791 -58.101 1.00 38.00 ? 503 LEU A C 1 ATOM 3866 O O . LEU A 1 472 ? -3.021 -19.896 -58.471 1.00 44.71 ? 503 LEU A O 1 ATOM 3867 C CB . LEU A 1 472 ? -3.299 -23.229 -57.948 1.00 36.51 ? 503 LEU A CB 1 ATOM 3868 C CG . LEU A 1 472 ? -2.647 -23.215 -59.334 1.00 33.84 ? 503 LEU A CG 1 ATOM 3869 C CD1 . LEU A 1 472 ? -1.156 -22.938 -59.230 1.00 32.91 ? 503 LEU A CD1 1 ATOM 3870 C CD2 . LEU A 1 472 ? -2.903 -24.524 -60.064 1.00 34.44 ? 503 LEU A CD2 1 ATOM 3871 N N . TYR A 1 473 ? -5.056 -20.855 -58.471 1.00 36.35 ? 504 TYR A N 1 ATOM 3872 C CA . TYR A 1 473 ? -5.605 -19.927 -59.459 1.00 36.26 ? 504 TYR A CA 1 ATOM 3873 C C . TYR A 1 473 ? -5.523 -18.445 -59.065 1.00 44.03 ? 504 TYR A C 1 ATOM 3874 O O . TYR A 1 473 ? -5.076 -17.632 -59.873 1.00 46.28 ? 504 TYR A O 1 ATOM 3875 C CB . TYR A 1 473 ? -7.060 -20.282 -59.783 1.00 36.66 ? 504 TYR A CB 1 ATOM 3876 C CG . TYR A 1 473 ? -7.728 -19.263 -60.678 1.00 41.15 ? 504 TYR A CG 1 ATOM 3877 C CD1 . TYR A 1 473 ? -7.374 -19.147 -62.016 1.00 39.35 ? 504 TYR A CD1 1 ATOM 3878 C CD2 . TYR A 1 473 ? -8.709 -18.411 -60.184 1.00 43.42 ? 504 TYR A CD2 1 ATOM 3879 C CE1 . TYR A 1 473 ? -7.979 -18.213 -62.839 1.00 44.23 ? 504 TYR A CE1 1 ATOM 3880 C CE2 . TYR A 1 473 ? -9.321 -17.475 -61.001 1.00 42.03 ? 504 TYR A CE2 1 ATOM 3881 C CZ . TYR A 1 473 ? -8.952 -17.381 -62.327 1.00 49.67 ? 504 TYR A CZ 1 ATOM 3882 O OH . TYR A 1 473 ? -9.556 -16.453 -63.145 1.00 58.92 ? 504 TYR A OH 1 ATOM 3883 N N . PRO A 1 474 ? -5.958 -18.077 -57.841 1.00 41.21 ? 505 PRO A N 1 ATOM 3884 C CA . PRO A 1 474 ? -5.827 -16.647 -57.530 1.00 38.43 ? 505 PRO A CA 1 ATOM 3885 C C . PRO A 1 474 ? -4.369 -16.208 -57.388 1.00 37.12 ? 505 PRO A C 1 ATOM 3886 O O . PRO A 1 474 ? -4.068 -15.031 -57.578 1.00 40.08 ? 505 PRO A O 1 ATOM 3887 C CB . PRO A 1 474 ? -6.579 -16.505 -56.203 1.00 34.44 ? 505 PRO A CB 1 ATOM 3888 C CG . PRO A 1 474 ? -6.532 -17.854 -55.594 1.00 43.89 ? 505 PRO A CG 1 ATOM 3889 C CD . PRO A 1 474 ? -6.606 -18.816 -56.741 1.00 40.21 ? 505 PRO A CD 1 ATOM 3890 N N . ALA A 1 475 ? -3.480 -17.144 -57.071 1.00 30.05 ? 506 ALA A N 1 ATOM 3891 C CA . ALA A 1 475 ? -2.059 -16.832 -56.969 1.00 35.86 ? 506 ALA A CA 1 ATOM 3892 C C . ALA A 1 475 ? -1.481 -16.478 -58.333 1.00 38.74 ? 506 ALA A C 1 ATOM 3893 O O . ALA A 1 475 ? -0.667 -15.567 -58.453 1.00 42.64 ? 506 ALA A O 1 ATOM 3894 C CB . ALA A 1 475 ? -1.301 -17.995 -56.364 1.00 32.04 ? 506 ALA A CB 1 ATOM 3895 N N . LEU A 1 476 ? -1.913 -17.204 -59.358 1.00 34.90 ? 507 LEU A N 1 ATOM 3896 C CA . LEU A 1 476 ? -1.448 -16.978 -60.722 1.00 35.93 ? 507 LEU A CA 1 ATOM 3897 C C . LEU A 1 476 ? -1.772 -15.571 -61.217 1.00 40.38 ? 507 LEU A C 1 ATOM 3898 O O . LEU A 1 476 ? -1.026 -15.002 -62.015 1.00 38.06 ? 507 LEU A O 1 ATOM 3899 C CB . LEU A 1 476 ? -2.064 -18.010 -61.668 1.00 31.41 ? 507 LEU A CB 1 ATOM 3900 C CG . LEU A 1 476 ? -1.588 -19.450 -61.505 1.00 29.83 ? 507 LEU A CG 1 ATOM 3901 C CD1 . LEU A 1 476 ? -2.455 -20.381 -62.331 1.00 30.99 ? 507 LEU A CD1 1 ATOM 3902 C CD2 . LEU A 1 476 ? -0.127 -19.576 -61.906 1.00 29.07 ? 507 LEU A CD2 1 ATOM 3903 N N . LEU A 1 477 ? -2.882 -15.014 -60.742 1.00 37.48 ? 508 LEU A N 1 ATOM 3904 C CA . LEU A 1 477 ? -3.334 -13.709 -61.207 1.00 34.60 ? 508 LEU A CA 1 ATOM 3905 C C . LEU A 1 477 ? -2.733 -12.554 -60.407 1.00 42.77 ? 508 LEU A C 1 ATOM 3906 O O . LEU A 1 477 ? -2.604 -11.445 -60.923 1.00 43.89 ? 508 LEU A O 1 ATOM 3907 C CB . LEU A 1 477 ? -4.859 -13.629 -61.164 1.00 31.62 ? 508 LEU A CB 1 ATOM 3908 C CG . LEU A 1 477 ? -5.606 -14.617 -62.062 1.00 38.02 ? 508 LEU A CG 1 ATOM 3909 C CD1 . LEU A 1 477 ? -7.097 -14.312 -62.080 1.00 31.05 ? 508 LEU A CD1 1 ATOM 3910 C CD2 . LEU A 1 477 ? -5.033 -14.616 -63.475 1.00 33.76 ? 508 LEU A CD2 1 ATOM 3911 N N . VAL A 1 478 ? -2.367 -12.810 -59.154 1.00 43.04 ? 509 VAL A N 1 ATOM 3912 C CA . VAL A 1 478 ? -1.804 -11.762 -58.305 1.00 39.01 ? 509 VAL A CA 1 ATOM 3913 C C . VAL A 1 478 ? -0.286 -11.846 -58.212 1.00 36.47 ? 509 VAL A C 1 ATOM 3914 O O . VAL A 1 478 ? 0.354 -10.950 -57.658 1.00 40.88 ? 509 VAL A O 1 ATOM 3915 C CB . VAL A 1 478 ? -2.376 -11.810 -56.872 1.00 36.35 ? 509 VAL A CB 1 ATOM 3916 C CG1 . VAL A 1 478 ? -3.893 -11.759 -56.899 1.00 38.25 ? 509 VAL A CG1 1 ATOM 3917 C CG2 . VAL A 1 478 ? -1.892 -13.054 -56.146 1.00 34.97 ? 509 VAL A CG2 1 ATOM 3918 N N . GLU A 1 479 ? 0.284 -12.922 -58.748 1.00 37.43 ? 510 GLU A N 1 ATOM 3919 C CA . GLU A 1 479 ? 1.720 -13.164 -58.648 1.00 35.21 ? 510 GLU A CA 1 ATOM 3920 C C . GLU A 1 479 ? 2.534 -12.017 -59.227 1.00 34.93 ? 510 GLU A C 1 ATOM 3921 O O . GLU A 1 479 ? 2.165 -11.442 -60.251 1.00 43.45 ? 510 GLU A O 1 ATOM 3922 C CB . GLU A 1 479 ? 2.095 -14.466 -59.359 1.00 33.87 ? 510 GLU A CB 1 ATOM 3923 C CG . GLU A 1 479 ? 3.552 -14.867 -59.191 1.00 38.44 ? 510 GLU A CG 1 ATOM 3924 C CD . GLU A 1 479 ? 3.878 -16.188 -59.854 1.00 44.71 ? 510 GLU A CD 1 ATOM 3925 O OE1 . GLU A 1 479 ? 3.345 -16.453 -60.951 1.00 43.48 ? 510 GLU A OE1 1 ATOM 3926 O OE2 . GLU A 1 479 ? 4.665 -16.966 -59.271 1.00 38.31 ? 510 GLU A OE2 1 ATOM 3927 N N . LYS A 1 480 ? 3.631 -11.684 -58.553 1.00 39.96 ? 511 LYS A N 1 ATOM 3928 C CA . LYS A 1 480 ? 4.584 -10.706 -59.059 1.00 38.63 ? 511 LYS A CA 1 ATOM 3929 C C . LYS A 1 480 ? 5.042 -11.087 -60.459 1.00 40.26 ? 511 LYS A C 1 ATOM 3930 O O . LYS A 1 480 ? 5.645 -12.143 -60.655 1.00 42.89 ? 511 LYS A O 1 ATOM 3931 C CB . LYS A 1 480 ? 5.791 -10.597 -58.127 1.00 36.39 ? 511 LYS A CB 1 ATOM 3932 C CG . LYS A 1 480 ? 6.984 -9.881 -58.736 1.00 39.73 ? 511 LYS A CG 1 ATOM 3933 C CD . LYS A 1 480 ? 8.253 -10.172 -57.951 1.00 51.96 ? 511 LYS A CD 1 ATOM 3934 C CE . LYS A 1 480 ? 9.485 -9.637 -58.664 1.00 64.32 ? 511 LYS A CE 1 ATOM 3935 N NZ . LYS A 1 480 ? 10.737 -9.974 -57.931 1.00 81.11 ? 511 LYS A NZ 1 ATOM 3936 N N . PRO A 1 481 ? 4.739 -10.234 -61.445 1.00 37.52 ? 512 PRO A N 1 ATOM 3937 C CA . PRO A 1 481 ? 5.149 -10.516 -62.822 1.00 28.66 ? 512 PRO A CA 1 ATOM 3938 C C . PRO A 1 481 ? 6.654 -10.401 -62.993 1.00 33.80 ? 512 PRO A C 1 ATOM 3939 O O . PRO A 1 481 ? 7.298 -9.660 -62.252 1.00 38.84 ? 512 PRO A O 1 ATOM 3940 C CB . PRO A 1 481 ? 4.428 -9.434 -63.638 1.00 27.27 ? 512 PRO A CB 1 ATOM 3941 C CG . PRO A 1 481 ? 3.369 -8.885 -62.729 1.00 34.25 ? 512 PRO A CG 1 ATOM 3942 C CD . PRO A 1 481 ? 3.926 -9.011 -61.349 1.00 32.54 ? 512 PRO A CD 1 ATOM 3943 N N . ARG A 1 482 ? 7.209 -11.140 -63.947 1.00 38.02 ? 513 ARG A N 1 ATOM 3944 C CA . ARG A 1 482 ? 8.576 -10.899 -64.379 1.00 29.58 ? 513 ARG A CA 1 ATOM 3945 C C . ARG A 1 482 ? 8.650 -9.470 -64.910 1.00 35.11 ? 513 ARG A C 1 ATOM 3946 O O . ARG A 1 482 ? 7.651 -8.944 -65.405 1.00 36.09 ? 513 ARG A O 1 ATOM 3947 C CB . ARG A 1 482 ? 9.000 -11.899 -65.455 1.00 32.88 ? 513 ARG A CB 1 ATOM 3948 C CG . ARG A 1 482 ? 9.794 -13.094 -64.948 1.00 37.50 ? 513 ARG A CG 1 ATOM 3949 C CD . ARG A 1 482 ? 8.921 -14.105 -64.224 1.00 42.27 ? 513 ARG A CD 1 ATOM 3950 N NE . ARG A 1 482 ? 9.672 -15.311 -63.882 1.00 44.65 ? 513 ARG A NE 1 ATOM 3951 C CZ . ARG A 1 482 ? 9.806 -16.362 -64.685 1.00 44.11 ? 513 ARG A CZ 1 ATOM 3952 N NH1 . ARG A 1 482 ? 9.234 -16.363 -65.881 1.00 42.05 ? 513 ARG A NH1 1 ATOM 3953 N NH2 . ARG A 1 482 ? 10.511 -17.415 -64.294 1.00 44.42 ? 513 ARG A NH2 1 ATOM 3954 N N . PRO A 1 483 ? 9.824 -8.831 -64.798 1.00 34.52 ? 514 PRO A N 1 ATOM 3955 C CA . PRO A 1 483 ? 9.998 -7.456 -65.280 1.00 33.82 ? 514 PRO A CA 1 ATOM 3956 C C . PRO A 1 483 ? 9.504 -7.246 -66.716 1.00 39.38 ? 514 PRO A C 1 ATOM 3957 O O . PRO A 1 483 ? 10.006 -7.882 -67.647 1.00 40.25 ? 514 PRO A O 1 ATOM 3958 C CB . PRO A 1 483 ? 11.511 -7.249 -65.188 1.00 30.83 ? 514 PRO A CB 1 ATOM 3959 C CG . PRO A 1 483 ? 11.935 -8.147 -64.080 1.00 25.91 ? 514 PRO A CG 1 ATOM 3960 C CD . PRO A 1 483 ? 11.049 -9.355 -64.170 1.00 31.67 ? 514 PRO A CD 1 ATOM 3961 N N . ASP A 1 484 ? 8.510 -6.372 -66.865 1.00 39.47 ? 515 ASP A N 1 ATOM 3962 C CA . ASP A 1 484 ? 7.939 -6.019 -68.166 1.00 41.12 ? 515 ASP A CA 1 ATOM 3963 C C . ASP A 1 484 ? 7.291 -7.208 -68.873 1.00 42.28 ? 515 ASP A C 1 ATOM 3964 O O . ASP A 1 484 ? 7.163 -7.210 -70.098 1.00 39.23 ? 515 ASP A O 1 ATOM 3965 C CB . ASP A 1 484 ? 9.011 -5.399 -69.069 1.00 29.24 ? 515 ASP A CB 1 ATOM 3966 C CG . ASP A 1 484 ? 9.568 -4.109 -68.507 1.00 41.08 ? 515 ASP A CG 1 ATOM 3967 O OD1 . ASP A 1 484 ? 8.764 -3.243 -68.104 1.00 50.29 ? 515 ASP A OD1 1 ATOM 3968 O OD2 . ASP A 1 484 ? 10.808 -3.963 -68.463 1.00 45.08 ? 515 ASP A OD2 1 ATOM 3969 N N . ALA A 1 485 ? 6.874 -8.208 -68.102 1.00 41.46 ? 516 ALA A N 1 ATOM 3970 C CA . ALA A 1 485 ? 6.260 -9.403 -68.673 1.00 33.65 ? 516 ALA A CA 1 ATOM 3971 C C . ALA A 1 485 ? 4.791 -9.525 -68.282 1.00 38.96 ? 516 ALA A C 1 ATOM 3972 O O . ALA A 1 485 ? 4.322 -8.847 -67.368 1.00 34.54 ? 516 ALA A O 1 ATOM 3973 C CB . ALA A 1 485 ? 7.023 -10.644 -68.244 1.00 33.61 ? 516 ALA A CB 1 ATOM 3974 N N . ILE A 1 486 ? 4.073 -10.402 -68.978 1.00 37.71 ? 517 ILE A N 1 ATOM 3975 C CA . ILE A 1 486 ? 2.645 -10.590 -68.745 1.00 33.65 ? 517 ILE A CA 1 ATOM 3976 C C . ILE A 1 486 ? 2.382 -11.621 -67.644 1.00 34.94 ? 517 ILE A C 1 ATOM 3977 O O . ILE A 1 486 ? 1.319 -11.619 -67.020 1.00 35.52 ? 517 ILE A O 1 ATOM 3978 C CB . ILE A 1 486 ? 1.922 -11.024 -70.048 1.00 36.77 ? 517 ILE A CB 1 ATOM 3979 C CG1 . ILE A 1 486 ? 0.404 -10.866 -69.914 1.00 38.40 ? 517 ILE A CG1 1 ATOM 3980 C CG2 . ILE A 1 486 ? 2.299 -12.450 -70.442 1.00 33.78 ? 517 ILE A CG2 1 ATOM 3981 C CD1 . ILE A 1 486 ? -0.360 -11.261 -71.159 1.00 31.79 ? 517 ILE A CD1 1 ATOM 3982 N N . PHE A 1 487 ? 3.358 -12.492 -67.403 1.00 38.12 ? 518 PHE A N 1 ATOM 3983 C CA . PHE A 1 487 ? 3.188 -13.595 -66.464 1.00 34.46 ? 518 PHE A CA 1 ATOM 3984 C C . PHE A 1 487 ? 4.172 -13.543 -65.306 1.00 38.65 ? 518 PHE A C 1 ATOM 3985 O O . PHE A 1 487 ? 5.195 -12.857 -65.370 1.00 34.21 ? 518 PHE A O 1 ATOM 3986 C CB . PHE A 1 487 ? 3.347 -14.940 -67.179 1.00 34.96 ? 518 PHE A CB 1 ATOM 3987 C CG . PHE A 1 487 ? 2.236 -15.263 -68.129 1.00 34.21 ? 518 PHE A CG 1 ATOM 3988 C CD1 . PHE A 1 487 ? 0.942 -14.840 -67.878 1.00 34.96 ? 518 PHE A CD1 1 ATOM 3989 C CD2 . PHE A 1 487 ? 2.486 -15.999 -69.276 1.00 32.27 ? 518 PHE A CD2 1 ATOM 3990 C CE1 . PHE A 1 487 ? -0.081 -15.143 -68.756 1.00 39.43 ? 518 PHE A CE1 1 ATOM 3991 C CE2 . PHE A 1 487 ? 1.468 -16.304 -70.156 1.00 29.99 ? 518 PHE A CE2 1 ATOM 3992 C CZ . PHE A 1 487 ? 0.183 -15.874 -69.897 1.00 37.11 ? 518 PHE A CZ 1 ATOM 3993 N N . GLY A 1 488 ? 3.849 -14.286 -64.251 1.00 39.16 ? 519 GLY A N 1 ATOM 3994 C CA . GLY A 1 488 ? 4.778 -14.533 -63.165 1.00 35.27 ? 519 GLY A CA 1 ATOM 3995 C C . GLY A 1 488 ? 5.512 -15.838 -63.416 1.00 44.65 ? 519 GLY A C 1 ATOM 3996 O O . GLY A 1 488 ? 5.347 -16.456 -64.468 1.00 46.21 ? 519 GLY A O 1 ATOM 3997 N N . GLU A 1 489 ? 6.319 -16.262 -62.449 1.00 41.09 ? 520 GLU A N 1 ATOM 3998 C CA . GLU A 1 489 ? 7.126 -17.470 -62.598 1.00 36.23 ? 520 GLU A CA 1 ATOM 3999 C C . GLU A 1 489 ? 6.286 -18.745 -62.655 1.00 41.51 ? 520 GLU A C 1 ATOM 4000 O O . GLU A 1 489 ? 6.577 -19.656 -63.431 1.00 39.39 ? 520 GLU A O 1 ATOM 4001 C CB . GLU A 1 489 ? 8.131 -17.576 -61.451 1.00 39.00 ? 520 GLU A CB 1 ATOM 4002 C CG . GLU A 1 489 ? 8.999 -18.821 -61.502 1.00 36.19 ? 520 GLU A CG 1 ATOM 4003 C CD . GLU A 1 489 ? 9.711 -19.084 -60.192 1.00 45.83 ? 520 GLU A CD 1 ATOM 4004 O OE1 . GLU A 1 489 ? 10.764 -19.755 -60.211 1.00 52.21 ? 520 GLU A OE1 1 ATOM 4005 O OE2 . GLU A 1 489 ? 9.214 -18.624 -59.142 1.00 41.21 ? 520 GLU A OE2 1 ATOM 4006 N N . THR A 1 490 ? 5.246 -18.806 -61.830 1.00 36.04 ? 521 THR A N 1 ATOM 4007 C CA . THR A 1 490 ? 4.446 -20.018 -61.703 1.00 32.74 ? 521 THR A CA 1 ATOM 4008 C C . THR A 1 490 ? 3.660 -20.326 -62.976 1.00 40.48 ? 521 THR A C 1 ATOM 4009 O O . THR A 1 490 ? 3.544 -21.485 -63.372 1.00 41.94 ? 521 THR A O 1 ATOM 4010 C CB . THR A 1 490 ? 3.465 -19.920 -60.519 1.00 36.47 ? 521 THR A CB 1 ATOM 4011 O OG1 . THR A 1 490 ? 4.178 -19.536 -59.337 1.00 37.78 ? 521 THR A OG1 1 ATOM 4012 C CG2 . THR A 1 490 ? 2.776 -21.259 -60.280 1.00 28.96 ? 521 THR A CG2 1 ATOM 4013 N N . MET A 1 491 ? 3.129 -19.289 -63.617 1.00 38.08 ? 522 MET A N 1 ATOM 4014 C CA . MET A 1 491 ? 2.326 -19.467 -64.825 1.00 30.58 ? 522 MET A CA 1 ATOM 4015 C C . MET A 1 491 ? 3.141 -20.077 -65.963 1.00 34.94 ? 522 MET A C 1 ATOM 4016 O O . MET A 1 491 ? 2.653 -20.935 -66.695 1.00 39.68 ? 522 MET A O 1 ATOM 4017 C CB . MET A 1 491 ? 1.725 -18.133 -65.275 1.00 30.92 ? 522 MET A CB 1 ATOM 4018 C CG . MET A 1 491 ? 0.871 -18.234 -66.526 1.00 24.82 ? 522 MET A CG 1 ATOM 4019 S SD . MET A 1 491 ? -0.750 -18.956 -66.200 1.00 41.84 ? 522 MET A SD 1 ATOM 4020 C CE . MET A 1 491 ? -1.609 -17.560 -65.478 1.00 32.08 ? 522 MET A CE 1 ATOM 4021 N N . VAL A 1 492 ? 4.385 -19.632 -66.104 1.00 31.37 ? 523 VAL A N 1 ATOM 4022 C CA . VAL A 1 492 ? 5.247 -20.109 -67.179 1.00 36.17 ? 523 VAL A CA 1 ATOM 4023 C C . VAL A 1 492 ? 5.761 -21.520 -66.911 1.00 35.99 ? 523 VAL A C 1 ATOM 4024 O O . VAL A 1 492 ? 5.736 -22.375 -67.794 1.00 39.00 ? 523 VAL A O 1 ATOM 4025 C CB . VAL A 1 492 ? 6.452 -19.169 -67.395 1.00 34.75 ? 523 VAL A CB 1 ATOM 4026 C CG1 . VAL A 1 492 ? 7.353 -19.704 -68.498 1.00 29.42 ? 523 VAL A CG1 1 ATOM 4027 C CG2 . VAL A 1 492 ? 5.974 -17.762 -67.721 1.00 38.37 ? 523 VAL A CG2 1 ATOM 4028 N N . GLU A 1 493 ? 6.217 -21.765 -65.687 1.00 35.76 ? 524 GLU A N 1 ATOM 4029 C CA . GLU A 1 493 ? 6.820 -23.051 -65.346 1.00 37.11 ? 524 GLU A CA 1 ATOM 4030 C C . GLU A 1 493 ? 5.788 -24.173 -65.230 1.00 41.21 ? 524 GLU A C 1 ATOM 4031 O O . GLU A 1 493 ? 6.142 -25.353 -65.250 1.00 37.95 ? 524 GLU A O 1 ATOM 4032 C CB . GLU A 1 493 ? 7.615 -22.930 -64.046 1.00 33.46 ? 524 GLU A CB 1 ATOM 4033 C CG . GLU A 1 493 ? 8.799 -21.982 -64.147 1.00 33.33 ? 524 GLU A CG 1 ATOM 4034 C CD . GLU A 1 493 ? 9.768 -22.372 -65.251 1.00 40.86 ? 524 GLU A CD 1 ATOM 4035 O OE1 . GLU A 1 493 ? 10.257 -23.522 -65.241 1.00 41.85 ? 524 GLU A OE1 1 ATOM 4036 O OE2 . GLU A 1 493 ? 10.044 -21.526 -66.129 1.00 41.97 ? 524 GLU A OE2 1 ATOM 4037 N N . LEU A 1 494 ? 4.517 -23.803 -65.108 1.00 36.53 ? 525 LEU A N 1 ATOM 4038 C CA . LEU A 1 494 ? 3.432 -24.779 -65.141 1.00 33.47 ? 525 LEU A CA 1 ATOM 4039 C C . LEU A 1 494 ? 2.856 -24.896 -66.548 1.00 38.36 ? 525 LEU A C 1 ATOM 4040 O O . LEU A 1 494 ? 2.629 -25.996 -67.048 1.00 41.08 ? 525 LEU A O 1 ATOM 4041 C CB . LEU A 1 494 ? 2.322 -24.400 -64.157 1.00 35.48 ? 525 LEU A CB 1 ATOM 4042 C CG . LEU A 1 494 ? 2.369 -25.004 -62.752 1.00 33.98 ? 525 LEU A CG 1 ATOM 4043 C CD1 . LEU A 1 494 ? 3.617 -24.562 -62.002 1.00 35.12 ? 525 LEU A CD1 1 ATOM 4044 C CD2 . LEU A 1 494 ? 1.115 -24.627 -61.983 1.00 33.23 ? 525 LEU A CD2 1 ATOM 4045 N N . GLY A 1 495 ? 2.625 -23.750 -67.179 1.00 39.45 ? 526 GLY A N 1 ATOM 4046 C CA . GLY A 1 495 ? 2.007 -23.707 -68.491 1.00 36.47 ? 526 GLY A CA 1 ATOM 4047 C C . GLY A 1 495 ? 2.845 -24.313 -69.601 1.00 34.93 ? 526 GLY A C 1 ATOM 4048 O O . GLY A 1 495 ? 2.314 -24.976 -70.490 1.00 35.83 ? 526 GLY A O 1 ATOM 4049 N N . ALA A 1 496 ? 4.155 -24.089 -69.551 1.00 29.10 ? 527 ALA A N 1 ATOM 4050 C CA . ALA A 1 496 ? 5.049 -24.552 -70.611 1.00 31.13 ? 527 ALA A CA 1 ATOM 4051 C C . ALA A 1 496 ? 5.088 -26.081 -70.776 1.00 36.67 ? 527 ALA A C 1 ATOM 4052 O O . ALA A 1 496 ? 5.015 -26.566 -71.907 1.00 34.86 ? 527 ALA A O 1 ATOM 4053 C CB . ALA A 1 496 ? 6.460 -24.010 -70.387 1.00 27.89 ? 527 ALA A CB 1 ATOM 4054 N N . PRO A 1 497 ? 5.217 -26.848 -69.669 1.00 37.71 ? 528 PRO A N 1 ATOM 4055 C CA . PRO A 1 497 ? 5.205 -28.305 -69.851 1.00 31.11 ? 528 PRO A CA 1 ATOM 4056 C C . PRO A 1 497 ? 3.911 -28.817 -70.474 1.00 30.51 ? 528 PRO A C 1 ATOM 4057 O O . PRO A 1 497 ? 3.975 -29.587 -71.427 1.00 32.59 ? 528 PRO A O 1 ATOM 4058 C CB . PRO A 1 497 ? 5.363 -28.839 -68.426 1.00 32.68 ? 528 PRO A CB 1 ATOM 4059 C CG . PRO A 1 497 ? 6.078 -27.768 -67.710 1.00 37.24 ? 528 PRO A CG 1 ATOM 4060 C CD . PRO A 1 497 ? 5.530 -26.491 -68.272 1.00 35.72 ? 528 PRO A CD 1 ATOM 4061 N N . PHE A 1 498 ? 2.766 -28.392 -69.947 1.00 30.77 ? 529 PHE A N 1 ATOM 4062 C CA . PHE A 1 498 ? 1.465 -28.772 -70.497 1.00 30.56 ? 529 PHE A CA 1 ATOM 4063 C C . PHE A 1 498 ? 1.340 -28.405 -71.972 1.00 33.58 ? 529 PHE A C 1 ATOM 4064 O O . PHE A 1 498 ? 0.903 -29.212 -72.791 1.00 35.65 ? 529 PHE A O 1 ATOM 4065 C CB . PHE A 1 498 ? 0.332 -28.100 -69.717 1.00 34.28 ? 529 PHE A CB 1 ATOM 4066 C CG . PHE A 1 498 ? 0.174 -28.599 -68.309 1.00 35.03 ? 529 PHE A CG 1 ATOM 4067 C CD1 . PHE A 1 498 ? 0.133 -29.954 -68.039 1.00 39.68 ? 529 PHE A CD1 1 ATOM 4068 C CD2 . PHE A 1 498 ? 0.059 -27.707 -67.255 1.00 33.92 ? 529 PHE A CD2 1 ATOM 4069 C CE1 . PHE A 1 498 ? -0.014 -30.412 -66.740 1.00 34.94 ? 529 PHE A CE1 1 ATOM 4070 C CE2 . PHE A 1 498 ? -0.087 -28.156 -65.958 1.00 38.35 ? 529 PHE A CE2 1 ATOM 4071 C CZ . PHE A 1 498 ? -0.124 -29.512 -65.699 1.00 34.66 ? 529 PHE A CZ 1 ATOM 4072 N N . SER A 1 499 ? 1.724 -27.177 -72.299 1.00 39.17 ? 530 SER A N 1 ATOM 4073 C CA . SER A 1 499 ? 1.548 -26.640 -73.642 1.00 30.83 ? 530 SER A CA 1 ATOM 4074 C C . SER A 1 499 ? 2.385 -27.376 -74.690 1.00 34.80 ? 530 SER A C 1 ATOM 4075 O O . SER A 1 499 ? 1.852 -27.862 -75.692 1.00 35.98 ? 530 SER A O 1 ATOM 4076 C CB . SER A 1 499 ? 1.893 -25.149 -73.653 1.00 27.03 ? 530 SER A CB 1 ATOM 4077 O OG . SER A 1 499 ? 1.649 -24.580 -74.926 1.00 48.91 ? 530 SER A OG 1 ATOM 4078 N N . LEU A 1 500 ? 3.693 -27.450 -74.459 1.00 32.84 ? 531 LEU A N 1 ATOM 4079 C CA . LEU A 1 500 ? 4.607 -28.065 -75.418 1.00 29.89 ? 531 LEU A CA 1 ATOM 4080 C C . LEU A 1 500 ? 4.356 -29.563 -75.573 1.00 31.57 ? 531 LEU A C 1 ATOM 4081 O O . LEU A 1 500 ? 4.480 -30.111 -76.667 1.00 31.00 ? 531 LEU A O 1 ATOM 4082 C CB . LEU A 1 500 ? 6.058 -27.814 -75.004 1.00 23.48 ? 531 LEU A CB 1 ATOM 4083 C CG . LEU A 1 500 ? 6.544 -26.366 -75.105 1.00 31.57 ? 531 LEU A CG 1 ATOM 4084 C CD1 . LEU A 1 500 ? 7.993 -26.260 -74.671 1.00 32.10 ? 531 LEU A CD1 1 ATOM 4085 C CD2 . LEU A 1 500 ? 6.372 -25.850 -76.523 1.00 26.07 ? 531 LEU A CD2 1 ATOM 4086 N N . LYS A 1 501 ? 4.000 -30.221 -74.476 1.00 34.97 ? 532 LYS A N 1 ATOM 4087 C CA . LYS A 1 501 ? 3.687 -31.646 -74.509 1.00 32.98 ? 532 LYS A CA 1 ATOM 4088 C C . LYS A 1 501 ? 2.443 -31.909 -75.355 1.00 31.47 ? 532 LYS A C 1 ATOM 4089 O O . LYS A 1 501 ? 2.376 -32.891 -76.093 1.00 38.57 ? 532 LYS A O 1 ATOM 4090 C CB . LYS A 1 501 ? 3.491 -32.180 -73.087 1.00 30.18 ? 532 LYS A CB 1 ATOM 4091 C CG . LYS A 1 501 ? 2.854 -33.554 -72.998 1.00 33.90 ? 532 LYS A CG 1 ATOM 4092 C CD . LYS A 1 501 ? 3.789 -34.644 -73.491 1.00 33.24 ? 532 LYS A CD 1 ATOM 4093 C CE . LYS A 1 501 ? 3.135 -36.012 -73.354 1.00 34.57 ? 532 LYS A CE 1 ATOM 4094 N NZ . LYS A 1 501 ? 4.038 -37.116 -73.779 1.00 34.27 ? 532 LYS A NZ 1 ATOM 4095 N N . GLY A 1 502 ? 1.466 -31.015 -75.253 1.00 31.52 ? 533 GLY A N 1 ATOM 4096 C CA . GLY A 1 502 ? 0.224 -31.157 -75.989 1.00 31.34 ? 533 GLY A CA 1 ATOM 4097 C C . GLY A 1 502 ? 0.397 -30.945 -77.479 1.00 33.50 ? 533 GLY A C 1 ATOM 4098 O O . GLY A 1 502 ? -0.356 -31.490 -78.283 1.00 34.08 ? 533 GLY A O 1 ATOM 4099 N N . LEU A 1 503 ? 1.396 -30.152 -77.850 1.00 38.19 ? 534 LEU A N 1 ATOM 4100 C CA . LEU A 1 503 ? 1.644 -29.841 -79.254 1.00 31.90 ? 534 LEU A CA 1 ATOM 4101 C C . LEU A 1 503 ? 2.456 -30.931 -79.951 1.00 32.92 ? 534 LEU A C 1 ATOM 4102 O O . LEU A 1 503 ? 2.120 -31.351 -81.058 1.00 32.24 ? 534 LEU A O 1 ATOM 4103 C CB . LEU A 1 503 ? 2.362 -28.496 -79.378 1.00 27.57 ? 534 LEU A CB 1 ATOM 4104 C CG . LEU A 1 503 ? 1.567 -27.264 -78.935 1.00 31.18 ? 534 LEU A CG 1 ATOM 4105 C CD1 . LEU A 1 503 ? 2.487 -26.080 -78.664 1.00 20.89 ? 534 LEU A CD1 1 ATOM 4106 C CD2 . LEU A 1 503 ? 0.531 -26.904 -79.985 1.00 26.37 ? 534 LEU A CD2 1 ATOM 4107 N N . MET A 1 504 ? 3.524 -31.387 -79.301 1.00 31.74 ? 535 MET A N 1 ATOM 4108 C CA . MET A 1 504 ? 4.415 -32.382 -79.895 1.00 29.33 ? 535 MET A CA 1 ATOM 4109 C C . MET A 1 504 ? 3.902 -33.808 -79.692 1.00 35.89 ? 535 MET A C 1 ATOM 4110 O O . MET A 1 504 ? 4.313 -34.728 -80.398 1.00 30.07 ? 535 MET A O 1 ATOM 4111 C CB . MET A 1 504 ? 5.826 -32.251 -79.317 1.00 21.73 ? 535 MET A CB 1 ATOM 4112 C CG . MET A 1 504 ? 6.459 -30.879 -79.509 1.00 24.16 ? 535 MET A CG 1 ATOM 4113 S SD . MET A 1 504 ? 6.553 -30.367 -81.239 1.00 38.93 ? 535 MET A SD 1 ATOM 4114 C CE . MET A 1 504 ? 7.609 -31.645 -81.925 1.00 29.34 ? 535 MET A CE 1 ATOM 4115 N N . GLY A 1 505 ? 3.000 -33.988 -78.733 1.00 35.10 ? 536 GLY A N 1 ATOM 4116 C CA . GLY A 1 505 ? 2.438 -35.299 -78.454 1.00 27.32 ? 536 GLY A CA 1 ATOM 4117 C C . GLY A 1 505 ? 1.385 -35.719 -79.462 1.00 31.31 ? 536 GLY A C 1 ATOM 4118 O O . GLY A 1 505 ? 0.726 -36.746 -79.302 1.00 34.14 ? 536 GLY A O 1 ATOM 4119 N N . ASN A 1 506 ? 1.225 -34.912 -80.504 1.00 35.22 ? 537 ASN A N 1 ATOM 4120 C CA . ASN A 1 506 ? 0.275 -35.187 -81.572 1.00 29.53 ? 537 ASN A CA 1 ATOM 4121 C C . ASN A 1 506 ? 0.817 -36.268 -82.503 1.00 29.84 ? 537 ASN A C 1 ATOM 4122 O O . ASN A 1 506 ? 2.015 -36.299 -82.779 1.00 36.68 ? 537 ASN A O 1 ATOM 4123 C CB . ASN A 1 506 ? -0.018 -33.899 -82.347 1.00 28.17 ? 537 ASN A CB 1 ATOM 4124 C CG . ASN A 1 506 ? -1.185 -34.038 -83.295 1.00 26.26 ? 537 ASN A CG 1 ATOM 4125 O OD1 . ASN A 1 506 ? -1.033 -34.518 -84.416 1.00 37.39 ? 537 ASN A OD1 1 ATOM 4126 N ND2 . ASN A 1 506 ? -2.361 -33.617 -82.849 1.00 27.88 ? 537 ASN A ND2 1 ATOM 4127 N N . PRO A 1 507 ? -0.060 -37.166 -82.985 1.00 30.42 ? 538 PRO A N 1 ATOM 4128 C CA . PRO A 1 507 ? 0.373 -38.270 -83.852 1.00 33.81 ? 538 PRO A CA 1 ATOM 4129 C C . PRO A 1 507 ? 1.025 -37.836 -85.165 1.00 32.43 ? 538 PRO A C 1 ATOM 4130 O O . PRO A 1 507 ? 1.822 -38.602 -85.704 1.00 35.79 ? 538 PRO A O 1 ATOM 4131 C CB . PRO A 1 507 ? -0.932 -39.033 -84.131 1.00 26.01 ? 538 PRO A CB 1 ATOM 4132 C CG . PRO A 1 507 ? -2.020 -38.084 -83.791 1.00 23.81 ? 538 PRO A CG 1 ATOM 4133 C CD . PRO A 1 507 ? -1.492 -37.261 -82.665 1.00 36.45 ? 538 PRO A CD 1 ATOM 4134 N N . ILE A 1 508 ? 0.711 -36.646 -85.672 1.00 30.23 ? 539 ILE A N 1 ATOM 4135 C CA . ILE A 1 508 ? 1.315 -36.203 -86.928 1.00 30.33 ? 539 ILE A CA 1 ATOM 4136 C C . ILE A 1 508 ? 2.772 -35.800 -86.725 1.00 32.20 ? 539 ILE A C 1 ATOM 4137 O O . ILE A 1 508 ? 3.511 -35.610 -87.691 1.00 32.65 ? 539 ILE A O 1 ATOM 4138 C CB . ILE A 1 508 ? 0.555 -35.019 -87.562 1.00 31.74 ? 539 ILE A CB 1 ATOM 4139 C CG1 . ILE A 1 508 ? 0.917 -33.705 -86.866 1.00 33.26 ? 539 ILE A CG1 1 ATOM 4140 C CG2 . ILE A 1 508 ? -0.949 -35.276 -87.561 1.00 33.23 ? 539 ILE A CG2 1 ATOM 4141 C CD1 . ILE A 1 508 ? 0.462 -32.483 -87.618 1.00 36.07 ? 539 ILE A CD1 1 ATOM 4142 N N . CYS A 1 509 ? 3.182 -35.671 -85.467 1.00 34.20 ? 540 CYS A N 1 ATOM 4143 C CA . CYS A 1 509 ? 4.568 -35.358 -85.144 1.00 28.19 ? 540 CYS A CA 1 ATOM 4144 C C . CYS A 1 509 ? 5.397 -36.632 -85.032 1.00 27.79 ? 540 CYS A C 1 ATOM 4145 O O . CYS A 1 509 ? 6.627 -36.580 -84.986 1.00 30.33 ? 540 CYS A O 1 ATOM 4146 C CB . CYS A 1 509 ? 4.655 -34.557 -83.843 1.00 25.66 ? 540 CYS A CB 1 ATOM 4147 S SG . CYS A 1 509 ? 3.898 -32.918 -83.922 1.00 38.84 ? 540 CYS A SG 1 ATOM 4148 N N . SER A 1 510 ? 4.713 -37.771 -84.985 1.00 32.00 ? 541 SER A N 1 ATOM 4149 C CA . SER A 1 510 ? 5.372 -39.070 -84.900 1.00 28.96 ? 541 SER A CA 1 ATOM 4150 C C . SER A 1 510 ? 6.028 -39.421 -86.232 1.00 30.70 ? 541 SER A C 1 ATOM 4151 O O . SER A 1 510 ? 5.513 -39.053 -87.289 1.00 37.44 ? 541 SER A O 1 ATOM 4152 C CB . SER A 1 510 ? 4.367 -40.151 -84.504 1.00 28.75 ? 541 SER A CB 1 ATOM 4153 O OG . SER A 1 510 ? 3.403 -40.345 -85.528 1.00 35.42 ? 541 SER A OG 1 ATOM 4154 N N . PRO A 1 511 ? 7.168 -40.132 -86.182 1.00 35.33 ? 542 PRO A N 1 ATOM 4155 C CA . PRO A 1 511 ? 7.957 -40.489 -87.369 1.00 36.08 ? 542 PRO A CA 1 ATOM 4156 C C . PRO A 1 511 ? 7.150 -41.123 -88.506 1.00 34.20 ? 542 PRO A C 1 ATOM 4157 O O . PRO A 1 511 ? 7.404 -40.792 -89.662 1.00 39.45 ? 542 PRO A O 1 ATOM 4158 C CB . PRO A 1 511 ? 8.991 -41.487 -86.819 1.00 21.06 ? 542 PRO A CB 1 ATOM 4159 C CG . PRO A 1 511 ? 8.561 -41.802 -85.419 1.00 30.71 ? 542 PRO A CG 1 ATOM 4160 C CD . PRO A 1 511 ? 7.814 -40.603 -84.948 1.00 33.51 ? 542 PRO A CD 1 ATOM 4161 N N . GLN A 1 512 ? 6.203 -42.003 -88.195 1.00 29.44 ? 543 GLN A N 1 ATOM 4162 C CA . GLN A 1 512 ? 5.417 -42.651 -89.246 1.00 39.08 ? 543 GLN A CA 1 ATOM 4163 C C . GLN A 1 512 ? 4.470 -41.684 -89.956 1.00 37.80 ? 543 GLN A C 1 ATOM 4164 O O . GLN A 1 512 ? 4.072 -41.927 -91.093 1.00 42.17 ? 543 GLN A O 1 ATOM 4165 C CB . GLN A 1 512 ? 4.618 -43.829 -88.681 1.00 44.01 ? 543 GLN A CB 1 ATOM 4166 C CG . GLN A 1 512 ? 5.359 -45.163 -88.703 1.00 64.20 ? 543 GLN A CG 1 ATOM 4167 C CD . GLN A 1 512 ? 5.727 -45.624 -90.108 1.00 62.77 ? 543 GLN A CD 1 ATOM 4168 O OE1 . GLN A 1 512 ? 6.767 -45.246 -90.647 1.00 58.37 ? 543 GLN A OE1 1 ATOM 4169 N NE2 . GLN A 1 512 ? 4.877 -46.456 -90.700 1.00 66.81 ? 543 GLN A NE2 1 ATOM 4170 N N . TYR A 1 513 ? 4.112 -40.592 -89.288 1.00 33.58 ? 544 TYR A N 1 ATOM 4171 C CA . TYR A 1 513 ? 3.203 -39.605 -89.866 1.00 30.18 ? 544 TYR A CA 1 ATOM 4172 C C . TYR A 1 513 ? 3.943 -38.438 -90.519 1.00 31.01 ? 544 TYR A C 1 ATOM 4173 O O . TYR A 1 513 ? 3.496 -37.900 -91.529 1.00 33.29 ? 544 TYR A O 1 ATOM 4174 C CB . TYR A 1 513 ? 2.255 -39.063 -88.797 1.00 29.31 ? 544 TYR A CB 1 ATOM 4175 C CG . TYR A 1 513 ? 0.982 -39.856 -88.595 1.00 31.52 ? 544 TYR A CG 1 ATOM 4176 C CD1 . TYR A 1 513 ? 0.994 -41.077 -87.931 1.00 34.46 ? 544 TYR A CD1 1 ATOM 4177 C CD2 . TYR A 1 513 ? -0.237 -39.365 -89.043 1.00 24.84 ? 544 TYR A CD2 1 ATOM 4178 C CE1 . TYR A 1 513 ? -0.172 -41.796 -87.736 1.00 22.60 ? 544 TYR A CE1 1 ATOM 4179 C CE2 . TYR A 1 513 ? -1.407 -40.075 -88.852 1.00 27.81 ? 544 TYR A CE2 1 ATOM 4180 C CZ . TYR A 1 513 ? -1.368 -41.289 -88.199 1.00 29.59 ? 544 TYR A CZ 1 ATOM 4181 O OH . TYR A 1 513 ? -2.528 -42.001 -88.006 1.00 29.43 ? 544 TYR A OH 1 ATOM 4182 N N . TRP A 1 514 ? 5.070 -38.044 -89.937 1.00 31.80 ? 545 TRP A N 1 ATOM 4183 C CA . TRP A 1 514 ? 5.774 -36.845 -90.384 1.00 28.27 ? 545 TRP A CA 1 ATOM 4184 C C . TRP A 1 514 ? 6.561 -37.074 -91.673 1.00 29.37 ? 545 TRP A C 1 ATOM 4185 O O . TRP A 1 514 ? 7.787 -37.172 -91.660 1.00 28.18 ? 545 TRP A O 1 ATOM 4186 C CB . TRP A 1 514 ? 6.706 -36.339 -89.282 1.00 26.45 ? 545 TRP A CB 1 ATOM 4187 C CG . TRP A 1 514 ? 7.260 -34.972 -89.552 1.00 30.15 ? 545 TRP A CG 1 ATOM 4188 C CD1 . TRP A 1 514 ? 8.566 -34.645 -89.776 1.00 29.62 ? 545 TRP A CD1 1 ATOM 4189 C CD2 . TRP A 1 514 ? 6.519 -33.747 -89.639 1.00 29.17 ? 545 TRP A CD2 1 ATOM 4190 N NE1 . TRP A 1 514 ? 8.684 -33.294 -89.988 1.00 29.95 ? 545 TRP A NE1 1 ATOM 4191 C CE2 . TRP A 1 514 ? 7.443 -32.720 -89.912 1.00 29.12 ? 545 TRP A CE2 1 ATOM 4192 C CE3 . TRP A 1 514 ? 5.166 -33.420 -89.510 1.00 24.94 ? 545 TRP A CE3 1 ATOM 4193 C CZ2 . TRP A 1 514 ? 7.059 -31.388 -90.058 1.00 30.63 ? 545 TRP A CZ2 1 ATOM 4194 C CZ3 . TRP A 1 514 ? 4.787 -32.098 -89.655 1.00 27.75 ? 545 TRP A CZ3 1 ATOM 4195 C CH2 . TRP A 1 514 ? 5.730 -31.098 -89.926 1.00 33.21 ? 545 TRP A CH2 1 ATOM 4196 N N . LYS A 1 515 ? 5.840 -37.145 -92.787 1.00 31.70 ? 546 LYS A N 1 ATOM 4197 C CA . LYS A 1 515 ? 6.445 -37.354 -94.098 1.00 31.67 ? 546 LYS A CA 1 ATOM 4198 C C . LYS A 1 515 ? 5.514 -36.802 -95.178 1.00 32.02 ? 546 LYS A C 1 ATOM 4199 O O . LYS A 1 515 ? 4.297 -36.802 -94.996 1.00 33.84 ? 546 LYS A O 1 ATOM 4200 C CB . LYS A 1 515 ? 6.736 -38.842 -94.326 1.00 32.73 ? 546 LYS A CB 1 ATOM 4201 C CG . LYS A 1 515 ? 5.505 -39.728 -94.304 1.00 38.17 ? 546 LYS A CG 1 ATOM 4202 C CD . LYS A 1 515 ? 5.868 -41.188 -94.521 1.00 43.80 ? 546 LYS A CD 1 ATOM 4203 C CE . LYS A 1 515 ? 6.722 -41.723 -93.384 1.00 40.36 ? 546 LYS A CE 1 ATOM 4204 N NZ . LYS A 1 515 ? 6.926 -43.195 -93.496 1.00 40.13 ? 546 LYS A NZ 1 ATOM 4205 N N . PRO A 1 516 ? 6.082 -36.319 -96.299 1.00 38.03 ? 547 PRO A N 1 ATOM 4206 C CA . PRO A 1 516 ? 5.332 -35.648 -97.372 1.00 33.89 ? 547 PRO A CA 1 ATOM 4207 C C . PRO A 1 516 ? 4.072 -36.380 -97.851 1.00 32.54 ? 547 PRO A C 1 ATOM 4208 O O . PRO A 1 516 ? 3.071 -35.723 -98.143 1.00 33.58 ? 547 PRO A O 1 ATOM 4209 C CB . PRO A 1 516 ? 6.357 -35.569 -98.505 1.00 30.89 ? 547 PRO A CB 1 ATOM 4210 C CG . PRO A 1 516 ? 7.663 -35.477 -97.803 1.00 33.73 ? 547 PRO A CG 1 ATOM 4211 C CD . PRO A 1 516 ? 7.530 -36.340 -96.579 1.00 34.16 ? 547 PRO A CD 1 ATOM 4212 N N . SER A 1 517 ? 4.118 -37.706 -97.932 1.00 28.46 ? 548 SER A N 1 ATOM 4213 C CA . SER A 1 517 ? 2.987 -38.473 -98.450 1.00 33.53 ? 548 SER A CA 1 ATOM 4214 C C . SER A 1 517 ? 1.753 -38.336 -97.561 1.00 31.39 ? 548 SER A C 1 ATOM 4215 O O . SER A 1 517 ? 0.621 -38.376 -98.047 1.00 34.60 ? 548 SER A O 1 ATOM 4216 C CB . SER A 1 517 ? 3.364 -39.948 -98.605 1.00 31.54 ? 548 SER A CB 1 ATOM 4217 O OG . SER A 1 517 ? 3.821 -40.492 -97.381 1.00 48.28 ? 548 SER A OG 1 ATOM 4218 N N . THR A 1 518 ? 1.977 -38.169 -96.261 1.00 24.59 ? 549 THR A N 1 ATOM 4219 C CA . THR A 1 518 ? 0.888 -37.983 -95.307 1.00 32.38 ? 549 THR A CA 1 ATOM 4220 C C . THR A 1 518 ? 0.064 -36.746 -95.651 1.00 32.76 ? 549 THR A C 1 ATOM 4221 O O . THR A 1 518 ? -1.153 -36.722 -95.463 1.00 29.74 ? 549 THR A O 1 ATOM 4222 C CB . THR A 1 518 ? 1.418 -37.847 -93.862 1.00 26.25 ? 549 THR A CB 1 ATOM 4223 O OG1 . THR A 1 518 ? 2.218 -38.988 -93.531 1.00 32.05 ? 549 THR A OG1 1 ATOM 4224 C CG2 . THR A 1 518 ? 0.271 -37.733 -92.867 1.00 22.16 ? 549 THR A CG2 1 ATOM 4225 N N . PHE A 1 519 ? 0.737 -35.725 -96.173 1.00 32.20 ? 550 PHE A N 1 ATOM 4226 C CA . PHE A 1 519 ? 0.099 -34.439 -96.416 1.00 29.63 ? 550 PHE A CA 1 ATOM 4227 C C . PHE A 1 519 ? -0.087 -34.152 -97.904 1.00 33.55 ? 550 PHE A C 1 ATOM 4228 O O . PHE A 1 519 ? -0.223 -32.997 -98.309 1.00 37.20 ? 550 PHE A O 1 ATOM 4229 C CB . PHE A 1 519 ? 0.914 -33.326 -95.758 1.00 27.15 ? 550 PHE A CB 1 ATOM 4230 C CG . PHE A 1 519 ? 1.260 -33.605 -94.322 1.00 30.81 ? 550 PHE A CG 1 ATOM 4231 C CD1 . PHE A 1 519 ? 0.318 -33.427 -93.322 1.00 27.47 ? 550 PHE A CD1 1 ATOM 4232 C CD2 . PHE A 1 519 ? 2.524 -34.051 -93.974 1.00 27.03 ? 550 PHE A CD2 1 ATOM 4233 C CE1 . PHE A 1 519 ? 0.633 -33.686 -92.000 1.00 29.63 ? 550 PHE A CE1 1 ATOM 4234 C CE2 . PHE A 1 519 ? 2.844 -34.310 -92.654 1.00 29.51 ? 550 PHE A CE2 1 ATOM 4235 C CZ . PHE A 1 519 ? 1.898 -34.127 -91.666 1.00 29.42 ? 550 PHE A CZ 1 ATOM 4236 N N . GLY A 1 520 ? -0.091 -35.206 -98.714 1.00 33.68 ? 551 GLY A N 1 ATOM 4237 C CA . GLY A 1 520 ? -0.393 -35.079 -100.129 1.00 36.21 ? 551 GLY A CA 1 ATOM 4238 C C . GLY A 1 520 ? 0.773 -34.679 -101.014 1.00 38.85 ? 551 GLY A C 1 ATOM 4239 O O . GLY A 1 520 ? 0.572 -34.221 -102.139 1.00 36.25 ? 551 GLY A O 1 ATOM 4240 N N . GLY A 1 521 ? 1.991 -34.854 -100.512 1.00 34.64 ? 552 GLY A N 1 ATOM 4241 C CA . GLY A 1 521 ? 3.182 -34.532 -101.279 1.00 28.12 ? 552 GLY A CA 1 ATOM 4242 C C . GLY A 1 521 ? 3.962 -33.369 -100.698 1.00 29.54 ? 552 GLY A C 1 ATOM 4243 O O . GLY A 1 521 ? 3.634 -32.871 -99.621 1.00 30.89 ? 552 GLY A O 1 ATOM 4244 N N . GLU A 1 522 ? 4.993 -32.934 -101.417 1.00 32.38 ? 553 GLU A N 1 ATOM 4245 C CA . GLU A 1 522 ? 5.858 -31.856 -100.950 1.00 32.85 ? 553 GLU A CA 1 ATOM 4246 C C . GLU A 1 522 ? 5.127 -30.519 -100.871 1.00 39.35 ? 553 GLU A C 1 ATOM 4247 O O . GLU A 1 522 ? 5.455 -29.676 -100.034 1.00 38.19 ? 553 GLU A O 1 ATOM 4248 C CB . GLU A 1 522 ? 7.083 -31.722 -101.858 1.00 28.66 ? 553 GLU A CB 1 ATOM 4249 C CG . GLU A 1 522 ? 8.015 -32.932 -101.846 1.00 48.64 ? 553 GLU A CG 1 ATOM 4250 C CD . GLU A 1 522 ? 8.853 -33.038 -100.577 1.00 66.31 ? 553 GLU A CD 1 ATOM 4251 O OE1 . GLU A 1 522 ? 8.731 -32.167 -99.688 1.00 49.05 ? 553 GLU A OE1 1 ATOM 4252 O OE2 . GLU A 1 522 ? 9.644 -34.000 -100.474 1.00 55.30 ? 553 GLU A OE2 1 ATOM 4253 N N . VAL A 1 523 ? 4.139 -30.329 -101.740 1.00 37.56 ? 554 VAL A N 1 ATOM 4254 C CA . VAL A 1 523 ? 3.373 -29.086 -101.754 1.00 38.44 ? 554 VAL A CA 1 ATOM 4255 C C . VAL A 1 523 ? 2.580 -28.928 -100.461 1.00 39.22 ? 554 VAL A C 1 ATOM 4256 O O . VAL A 1 523 ? 2.641 -27.883 -99.810 1.00 38.07 ? 554 VAL A O 1 ATOM 4257 C CB . VAL A 1 523 ? 2.412 -29.020 -102.957 1.00 37.09 ? 554 VAL A CB 1 ATOM 4258 C CG1 . VAL A 1 523 ? 1.471 -27.837 -102.820 1.00 28.27 ? 554 VAL A CG1 1 ATOM 4259 C CG2 . VAL A 1 523 ? 3.195 -28.925 -104.257 1.00 30.92 ? 554 VAL A CG2 1 ATOM 4260 N N . GLY A 1 524 ? 1.846 -29.973 -100.089 1.00 38.57 ? 555 GLY A N 1 ATOM 4261 C CA . GLY A 1 524 ? 1.079 -29.966 -98.856 1.00 31.93 ? 555 GLY A CA 1 ATOM 4262 C C . GLY A 1 524 ? 1.975 -29.860 -97.637 1.00 32.67 ? 555 GLY A C 1 ATOM 4263 O O . GLY A 1 524 ? 1.658 -29.151 -96.682 1.00 30.41 ? 555 GLY A O 1 ATOM 4264 N N . PHE A 1 525 ? 3.101 -30.567 -97.676 1.00 30.00 ? 556 PHE A N 1 ATOM 4265 C CA . PHE A 1 525 ? 4.071 -30.544 -96.588 1.00 26.85 ? 556 PHE A CA 1 ATOM 4266 C C . PHE A 1 525 ? 4.612 -29.131 -96.374 1.00 37.52 ? 556 PHE A C 1 ATOM 4267 O O . PHE A 1 525 ? 4.789 -28.690 -95.238 1.00 38.11 ? 556 PHE A O 1 ATOM 4268 C CB . PHE A 1 525 ? 5.221 -31.511 -96.879 1.00 29.96 ? 556 PHE A CB 1 ATOM 4269 C CG . PHE A 1 525 ? 5.922 -32.015 -95.648 1.00 32.48 ? 556 PHE A CG 1 ATOM 4270 C CD1 . PHE A 1 525 ? 5.276 -32.037 -94.423 1.00 35.76 ? 556 PHE A CD1 1 ATOM 4271 C CD2 . PHE A 1 525 ? 7.232 -32.464 -95.716 1.00 37.09 ? 556 PHE A CD2 1 ATOM 4272 C CE1 . PHE A 1 525 ? 5.920 -32.504 -93.290 1.00 32.97 ? 556 PHE A CE1 1 ATOM 4273 C CE2 . PHE A 1 525 ? 7.882 -32.929 -94.589 1.00 31.43 ? 556 PHE A CE2 1 ATOM 4274 C CZ . PHE A 1 525 ? 7.224 -32.949 -93.373 1.00 30.28 ? 556 PHE A CZ 1 ATOM 4275 N N . LYS A 1 526 ? 4.863 -28.426 -97.475 1.00 37.23 ? 557 LYS A N 1 ATOM 4276 C CA . LYS A 1 526 ? 5.426 -27.080 -97.424 1.00 31.89 ? 557 LYS A CA 1 ATOM 4277 C C . LYS A 1 526 ? 4.440 -26.070 -96.837 1.00 36.50 ? 557 LYS A C 1 ATOM 4278 O O . LYS A 1 526 ? 4.848 -25.073 -96.236 1.00 31.05 ? 557 LYS A O 1 ATOM 4279 C CB . LYS A 1 526 ? 5.864 -26.631 -98.820 1.00 34.99 ? 557 LYS A CB 1 ATOM 4280 C CG . LYS A 1 526 ? 6.620 -25.305 -98.842 1.00 32.60 ? 557 LYS A CG 1 ATOM 4281 C CD . LYS A 1 526 ? 7.020 -24.914 -100.254 1.00 35.53 ? 557 LYS A CD 1 ATOM 4282 C CE . LYS A 1 526 ? 7.791 -23.603 -100.263 1.00 51.02 ? 557 LYS A CE 1 ATOM 4283 N NZ . LYS A 1 526 ? 8.210 -23.213 -101.637 1.00 57.55 ? 557 LYS A NZ 1 ATOM 4284 N N . ILE A 1 527 ? 3.147 -26.327 -97.015 1.00 31.66 ? 558 ILE A N 1 ATOM 4285 C CA . ILE A 1 527 ? 2.112 -25.471 -96.438 1.00 26.75 ? 558 ILE A CA 1 ATOM 4286 C C . ILE A 1 527 ? 2.260 -25.412 -94.918 1.00 30.64 ? 558 ILE A C 1 ATOM 4287 O O . ILE A 1 527 ? 2.101 -24.356 -94.307 1.00 36.77 ? 558 ILE A O 1 ATOM 4288 C CB . ILE A 1 527 ? 0.693 -25.965 -96.800 1.00 25.01 ? 558 ILE A CB 1 ATOM 4289 C CG1 . ILE A 1 527 ? 0.486 -25.932 -98.314 1.00 22.85 ? 558 ILE A CG1 1 ATOM 4290 C CG2 . ILE A 1 527 ? -0.364 -25.120 -96.113 1.00 23.48 ? 558 ILE A CG2 1 ATOM 4291 C CD1 . ILE A 1 527 ? -0.897 -26.370 -98.752 1.00 23.95 ? 558 ILE A CD1 1 ATOM 4292 N N . ILE A 1 528 ? 2.581 -26.555 -94.321 1.00 32.50 ? 559 ILE A N 1 ATOM 4293 C CA . ILE A 1 528 ? 2.768 -26.652 -92.880 1.00 27.10 ? 559 ILE A CA 1 ATOM 4294 C C . ILE A 1 528 ? 4.046 -25.956 -92.427 1.00 35.21 ? 559 ILE A C 1 ATOM 4295 O O . ILE A 1 528 ? 4.034 -25.143 -91.499 1.00 37.74 ? 559 ILE A O 1 ATOM 4296 C CB . ILE A 1 528 ? 2.826 -28.121 -92.422 1.00 35.06 ? 559 ILE A CB 1 ATOM 4297 C CG1 . ILE A 1 528 ? 1.507 -28.833 -92.720 1.00 34.58 ? 559 ILE A CG1 1 ATOM 4298 C CG2 . ILE A 1 528 ? 3.165 -28.208 -90.942 1.00 29.32 ? 559 ILE A CG2 1 ATOM 4299 C CD1 . ILE A 1 528 ? 1.485 -30.269 -92.255 1.00 27.54 ? 559 ILE A CD1 1 ATOM 4300 N N . ASN A 1 529 ? 5.149 -26.281 -93.091 1.00 33.13 ? 560 ASN A N 1 ATOM 4301 C CA . ASN A 1 529 ? 6.463 -25.821 -92.660 1.00 36.75 ? 560 ASN A CA 1 ATOM 4302 C C . ASN A 1 529 ? 6.738 -24.346 -92.953 1.00 33.91 ? 560 ASN A C 1 ATOM 4303 O O . ASN A 1 529 ? 7.742 -23.801 -92.500 1.00 38.46 ? 560 ASN A O 1 ATOM 4304 C CB . ASN A 1 529 ? 7.545 -26.686 -93.304 1.00 28.08 ? 560 ASN A CB 1 ATOM 4305 C CG . ASN A 1 529 ? 7.562 -28.099 -92.753 1.00 35.31 ? 560 ASN A CG 1 ATOM 4306 O OD1 . ASN A 1 529 ? 7.509 -28.306 -91.540 1.00 35.79 ? 560 ASN A OD1 1 ATOM 4307 N ND2 . ASN A 1 529 ? 7.627 -29.082 -93.644 1.00 40.50 ? 560 ASN A ND2 1 ATOM 4308 N N . THR A 1 530 ? 5.845 -23.703 -93.701 1.00 36.91 ? 561 THR A N 1 ATOM 4309 C CA . THR A 1 530 ? 5.979 -22.278 -93.998 1.00 29.23 ? 561 THR A CA 1 ATOM 4310 C C . THR A 1 530 ? 4.828 -21.461 -93.406 1.00 32.57 ? 561 THR A C 1 ATOM 4311 O O . THR A 1 530 ? 4.718 -20.260 -93.651 1.00 40.34 ? 561 THR A O 1 ATOM 4312 C CB . THR A 1 530 ? 6.036 -22.024 -95.513 1.00 28.36 ? 561 THR A CB 1 ATOM 4313 O OG1 . THR A 1 530 ? 4.804 -22.445 -96.112 1.00 39.62 ? 561 THR A OG1 1 ATOM 4314 C CG2 . THR A 1 530 ? 7.187 -22.792 -96.141 1.00 28.43 ? 561 THR A CG2 1 ATOM 4315 N N . ALA A 1 531 ? 3.973 -22.119 -92.629 1.00 32.80 ? 562 ALA A N 1 ATOM 4316 C CA . ALA A 1 531 ? 2.794 -21.472 -92.065 1.00 30.62 ? 562 ALA A CA 1 ATOM 4317 C C . ALA A 1 531 ? 3.168 -20.424 -91.023 1.00 27.91 ? 562 ALA A C 1 ATOM 4318 O O . ALA A 1 531 ? 4.175 -20.554 -90.327 1.00 31.35 ? 562 ALA A O 1 ATOM 4319 C CB . ALA A 1 531 ? 1.859 -22.509 -91.455 1.00 28.81 ? 562 ALA A CB 1 ATOM 4320 N N . SER A 1 532 ? 2.345 -19.386 -90.926 1.00 26.72 ? 563 SER A N 1 ATOM 4321 C CA . SER A 1 532 ? 2.531 -18.328 -89.938 1.00 27.93 ? 563 SER A CA 1 ATOM 4322 C C . SER A 1 532 ? 1.221 -17.579 -89.734 1.00 28.28 ? 563 SER A C 1 ATOM 4323 O O . SER A 1 532 ? 0.313 -17.672 -90.562 1.00 34.14 ? 563 SER A O 1 ATOM 4324 C CB . SER A 1 532 ? 3.637 -17.362 -90.370 1.00 23.80 ? 563 SER A CB 1 ATOM 4325 O OG . SER A 1 532 ? 3.256 -16.625 -91.517 1.00 29.36 ? 563 SER A OG 1 ATOM 4326 N N . ILE A 1 533 ? 1.123 -16.836 -88.636 1.00 25.30 ? 564 ILE A N 1 ATOM 4327 C CA . ILE A 1 533 ? -0.098 -16.093 -88.339 1.00 26.86 ? 564 ILE A CA 1 ATOM 4328 C C . ILE A 1 533 ? -0.328 -14.989 -89.373 1.00 26.24 ? 564 ILE A C 1 ATOM 4329 O O . ILE A 1 533 ? -1.468 -14.649 -89.680 1.00 37.67 ? 564 ILE A O 1 ATOM 4330 C CB . ILE A 1 533 ? -0.067 -15.487 -86.910 1.00 25.86 ? 564 ILE A CB 1 ATOM 4331 C CG1 . ILE A 1 533 ? -1.417 -14.862 -86.557 1.00 26.06 ? 564 ILE A CG1 1 ATOM 4332 C CG2 . ILE A 1 533 ? 1.057 -14.475 -86.766 1.00 26.44 ? 564 ILE A CG2 1 ATOM 4333 C CD1 . ILE A 1 533 ? -2.593 -15.814 -86.700 1.00 24.59 ? 564 ILE A CD1 1 ATOM 4334 N N . GLN A 1 534 ? 0.751 -14.447 -89.929 1.00 30.86 ? 565 GLN A N 1 ATOM 4335 C CA . GLN A 1 534 ? 0.627 -13.420 -90.956 1.00 32.04 ? 565 GLN A CA 1 ATOM 4336 C C . GLN A 1 534 ? 0.162 -14.017 -92.282 1.00 32.92 ? 565 GLN A C 1 ATOM 4337 O O . GLN A 1 534 ? -0.709 -13.460 -92.949 1.00 31.70 ? 565 GLN A O 1 ATOM 4338 C CB . GLN A 1 534 ? 1.952 -12.682 -91.151 1.00 22.31 ? 565 GLN A CB 1 ATOM 4339 C CG . GLN A 1 534 ? 1.944 -11.684 -92.308 1.00 38.93 ? 565 GLN A CG 1 ATOM 4340 C CD . GLN A 1 534 ? 0.971 -10.530 -92.100 1.00 59.60 ? 565 GLN A CD 1 ATOM 4341 O OE1 . GLN A 1 534 ? 1.316 -9.516 -91.491 1.00 54.09 ? 565 GLN A OE1 1 ATOM 4342 N NE2 . GLN A 1 534 ? -0.247 -10.676 -92.618 1.00 27.89 ? 565 GLN A NE2 1 ATOM 4343 N N . SER A 1 535 ? 0.745 -15.151 -92.659 1.00 28.55 ? 566 SER A N 1 ATOM 4344 C CA . SER A 1 535 ? 0.395 -15.804 -93.915 1.00 31.29 ? 566 SER A CA 1 ATOM 4345 C C . SER A 1 535 ? -1.026 -16.364 -93.872 1.00 30.99 ? 566 SER A C 1 ATOM 4346 O O . SER A 1 535 ? -1.690 -16.467 -94.905 1.00 33.10 ? 566 SER A O 1 ATOM 4347 C CB . SER A 1 535 ? 1.396 -16.916 -94.238 1.00 21.87 ? 566 SER A CB 1 ATOM 4348 O OG . SER A 1 535 ? 1.307 -17.963 -93.293 1.00 39.03 ? 566 SER A OG 1 ATOM 4349 N N . LEU A 1 536 ? -1.489 -16.725 -92.679 1.00 24.75 ? 567 LEU A N 1 ATOM 4350 C CA . LEU A 1 536 ? -2.849 -17.225 -92.518 1.00 24.93 ? 567 LEU A CA 1 ATOM 4351 C C . LEU A 1 536 ? -3.859 -16.122 -92.816 1.00 34.50 ? 567 LEU A C 1 ATOM 4352 O O . LEU A 1 536 ? -4.842 -16.339 -93.527 1.00 33.94 ? 567 LEU A O 1 ATOM 4353 C CB . LEU A 1 536 ? -3.065 -17.770 -91.107 1.00 26.93 ? 567 LEU A CB 1 ATOM 4354 C CG . LEU A 1 536 ? -4.428 -18.427 -90.866 1.00 34.41 ? 567 LEU A CG 1 ATOM 4355 C CD1 . LEU A 1 536 ? -4.528 -19.761 -91.599 1.00 27.08 ? 567 LEU A CD1 1 ATOM 4356 C CD2 . LEU A 1 536 ? -4.708 -18.597 -89.379 1.00 29.18 ? 567 LEU A CD2 1 ATOM 4357 N N . ILE A 1 537 ? -3.603 -14.937 -92.271 1.00 32.03 ? 568 ILE A N 1 ATOM 4358 C CA . ILE A 1 537 ? -4.462 -13.782 -92.499 1.00 29.31 ? 568 ILE A CA 1 ATOM 4359 C C . ILE A 1 537 ? -4.289 -13.263 -93.929 1.00 31.90 ? 568 ILE A C 1 ATOM 4360 O O . ILE A 1 537 ? -5.260 -12.892 -94.588 1.00 32.82 ? 568 ILE A O 1 ATOM 4361 C CB . ILE A 1 537 ? -4.169 -12.659 -91.477 1.00 24.08 ? 568 ILE A CB 1 ATOM 4362 C CG1 . ILE A 1 537 ? -5.079 -12.795 -90.253 1.00 30.41 ? 568 ILE A CG1 1 ATOM 4363 C CG2 . ILE A 1 537 ? -4.381 -11.286 -92.086 1.00 27.54 ? 568 ILE A CG2 1 ATOM 4364 C CD1 . ILE A 1 537 ? -4.872 -14.060 -89.450 1.00 33.44 ? 568 ILE A CD1 1 ATOM 4365 N N . CYS A 1 538 ? -3.052 -13.264 -94.414 1.00 34.82 ? 569 CYS A N 1 ATOM 4366 C CA . CYS A 1 538 ? -2.752 -12.757 -95.749 1.00 28.66 ? 569 CYS A CA 1 ATOM 4367 C C . CYS A 1 538 ? -3.480 -13.539 -96.842 1.00 31.61 ? 569 CYS A C 1 ATOM 4368 O O . CYS A 1 538 ? -3.967 -12.956 -97.811 1.00 36.08 ? 569 CYS A O 1 ATOM 4369 C CB . CYS A 1 538 ? -1.245 -12.794 -96.004 1.00 27.50 ? 569 CYS A CB 1 ATOM 4370 S SG . CYS A 1 538 ? -0.747 -12.169 -97.624 1.00 44.83 ? 569 CYS A SG 1 ATOM 4371 N N . ASN A 1 539 ? -3.558 -14.856 -96.680 1.00 31.40 ? 570 ASN A N 1 ATOM 4372 C CA . ASN A 1 539 ? -4.165 -15.715 -97.693 1.00 28.32 ? 570 ASN A CA 1 ATOM 4373 C C . ASN A 1 539 ? -5.689 -15.775 -97.620 1.00 33.30 ? 570 ASN A C 1 ATOM 4374 O O . ASN A 1 539 ? -6.344 -16.153 -98.590 1.00 35.86 ? 570 ASN A O 1 ATOM 4375 C CB . ASN A 1 539 ? -3.608 -17.136 -97.588 1.00 28.48 ? 570 ASN A CB 1 ATOM 4376 C CG . ASN A 1 539 ? -2.155 -17.231 -98.016 1.00 35.23 ? 570 ASN A CG 1 ATOM 4377 O OD1 . ASN A 1 539 ? -1.668 -16.411 -98.794 1.00 36.85 ? 570 ASN A OD1 1 ATOM 4378 N ND2 . ASN A 1 539 ? -1.458 -18.245 -97.517 1.00 28.32 ? 570 ASN A ND2 1 ATOM 4379 N N . ASN A 1 540 ? -6.256 -15.407 -96.475 1.00 31.98 ? 571 ASN A N 1 ATOM 4380 C CA . ASN A 1 540 ? -7.683 -15.620 -96.245 1.00 31.95 ? 571 ASN A CA 1 ATOM 4381 C C . ASN A 1 540 ? -8.471 -14.365 -95.884 1.00 36.63 ? 571 ASN A C 1 ATOM 4382 O O . ASN A 1 540 ? -9.693 -14.413 -95.763 1.00 33.52 ? 571 ASN A O 1 ATOM 4383 C CB . ASN A 1 540 ? -7.874 -16.666 -95.148 1.00 27.01 ? 571 ASN A CB 1 ATOM 4384 C CG . ASN A 1 540 ? -7.283 -18.010 -95.520 1.00 30.23 ? 571 ASN A CG 1 ATOM 4385 O OD1 . ASN A 1 540 ? -7.567 -18.550 -96.589 1.00 28.04 ? 571 ASN A OD1 1 ATOM 4386 N ND2 . ASN A 1 540 ? -6.446 -18.551 -94.644 1.00 33.77 ? 571 ASN A ND2 1 ATOM 4387 N N . VAL A 1 541 ? -7.781 -13.244 -95.709 1.00 31.95 ? 572 VAL A N 1 ATOM 4388 C CA . VAL A 1 541 ? -8.468 -11.988 -95.427 1.00 30.11 ? 572 VAL A CA 1 ATOM 4389 C C . VAL A 1 541 ? -8.261 -10.999 -96.576 1.00 39.23 ? 572 VAL A C 1 ATOM 4390 O O . VAL A 1 541 ? -7.166 -10.897 -97.133 1.00 39.92 ? 572 VAL A O 1 ATOM 4391 C CB . VAL A 1 541 ? -7.992 -11.372 -94.099 1.00 31.76 ? 572 VAL A CB 1 ATOM 4392 C CG1 . VAL A 1 541 ? -8.769 -10.105 -93.784 1.00 31.52 ? 572 VAL A CG1 1 ATOM 4393 C CG2 . VAL A 1 541 ? -8.149 -12.381 -92.970 1.00 29.79 ? 572 VAL A CG2 1 ATOM 4394 N N . LYS A 1 542 ? -9.326 -10.288 -96.934 1.00 38.98 ? 573 LYS A N 1 ATOM 4395 C CA . LYS A 1 542 ? -9.311 -9.362 -98.062 1.00 30.34 ? 573 LYS A CA 1 ATOM 4396 C C . LYS A 1 542 ? -8.291 -8.240 -97.890 1.00 36.67 ? 573 LYS A C 1 ATOM 4397 O O . LYS A 1 542 ? -8.280 -7.541 -96.876 1.00 29.72 ? 573 LYS A O 1 ATOM 4398 C CB . LYS A 1 542 ? -10.704 -8.768 -98.264 1.00 33.04 ? 573 LYS A CB 1 ATOM 4399 C CG . LYS A 1 542 ? -10.827 -7.827 -99.450 1.00 41.85 ? 573 LYS A CG 1 ATOM 4400 C CD . LYS A 1 542 ? -12.252 -7.316 -99.584 1.00 44.24 ? 573 LYS A CD 1 ATOM 4401 C CE . LYS A 1 542 ? -12.422 -6.443 -100.814 1.00 48.85 ? 573 LYS A CE 1 ATOM 4402 N NZ . LYS A 1 542 ? -13.825 -5.959 -100.936 1.00 57.46 ? 573 LYS A NZ 1 ATOM 4403 N N . GLY A 1 543 ? -7.434 -8.077 -98.892 1.00 34.88 ? 574 GLY A N 1 ATOM 4404 C CA . GLY A 1 543 ? -6.452 -7.010 -98.895 1.00 22.47 ? 574 GLY A CA 1 ATOM 4405 C C . GLY A 1 543 ? -5.111 -7.424 -98.325 1.00 33.20 ? 574 GLY A C 1 ATOM 4406 O O . GLY A 1 543 ? -4.145 -6.663 -98.397 1.00 32.00 ? 574 GLY A O 1 ATOM 4407 N N . CYS A 1 544 ? -5.054 -8.636 -97.775 1.00 38.67 ? 575 CYS A N 1 ATOM 4408 C CA . CYS A 1 544 ? -3.864 -9.142 -97.087 1.00 27.38 ? 575 CYS A CA 1 ATOM 4409 C C . CYS A 1 544 ? -3.362 -8.139 -96.052 1.00 26.72 ? 575 CYS A C 1 ATOM 4410 O O . CYS A 1 544 ? -2.255 -7.616 -96.179 1.00 31.11 ? 575 CYS A O 1 ATOM 4411 C CB . CYS A 1 544 ? -2.752 -9.468 -98.091 1.00 23.13 ? 575 CYS A CB 1 ATOM 4412 S SG . CYS A 1 544 ? -1.257 -10.215 -97.379 1.00 38.98 ? 575 CYS A SG 1 ATOM 4413 N N . PRO A 1 545 ? -4.180 -7.861 -95.024 1.00 26.19 ? 576 PRO A N 1 ATOM 4414 C CA . PRO A 1 545 ? -3.802 -6.836 -94.048 1.00 28.97 ? 576 PRO A CA 1 ATOM 4415 C C . PRO A 1 545 ? -2.637 -7.276 -93.173 1.00 32.87 ? 576 PRO A C 1 ATOM 4416 O O . PRO A 1 545 ? -2.436 -8.472 -92.972 1.00 36.24 ? 576 PRO A O 1 ATOM 4417 C CB . PRO A 1 545 ? -5.073 -6.664 -93.215 1.00 28.79 ? 576 PRO A CB 1 ATOM 4418 C CG . PRO A 1 545 ? -5.741 -7.988 -93.291 1.00 28.96 ? 576 PRO A CG 1 ATOM 4419 C CD . PRO A 1 545 ? -5.456 -8.511 -94.673 1.00 31.60 ? 576 PRO A CD 1 ATOM 4420 N N . PHE A 1 546 ? -1.874 -6.312 -92.671 1.00 33.69 ? 577 PHE A N 1 ATOM 4421 C CA . PHE A 1 546 ? -0.807 -6.604 -91.726 1.00 32.63 ? 577 PHE A CA 1 ATOM 4422 C C . PHE A 1 546 ? -1.406 -7.094 -90.416 1.00 37.29 ? 577 PHE A C 1 ATOM 4423 O O . PHE A 1 546 ? -2.429 -6.577 -89.962 1.00 38.92 ? 577 PHE A O 1 ATOM 4424 C CB . PHE A 1 546 ? 0.060 -5.366 -91.486 1.00 32.69 ? 577 PHE A CB 1 ATOM 4425 C CG . PHE A 1 546 ? 1.057 -5.529 -90.374 1.00 29.97 ? 577 PHE A CG 1 ATOM 4426 C CD1 . PHE A 1 546 ? 2.285 -6.123 -90.611 1.00 32.49 ? 577 PHE A CD1 1 ATOM 4427 C CD2 . PHE A 1 546 ? 0.770 -5.081 -89.093 1.00 27.09 ? 577 PHE A CD2 1 ATOM 4428 C CE1 . PHE A 1 546 ? 3.204 -6.273 -89.590 1.00 32.48 ? 577 PHE A CE1 1 ATOM 4429 C CE2 . PHE A 1 546 ? 1.685 -5.230 -88.070 1.00 38.74 ? 577 PHE A CE2 1 ATOM 4430 C CZ . PHE A 1 546 ? 2.904 -5.826 -88.318 1.00 35.37 ? 577 PHE A CZ 1 ATOM 4431 N N . THR A 1 547 ? -0.775 -8.094 -89.811 1.00 29.93 ? 578 THR A N 1 ATOM 4432 C CA . THR A 1 547 ? -1.222 -8.581 -88.513 1.00 35.70 ? 578 THR A CA 1 ATOM 4433 C C . THR A 1 547 ? -0.057 -9.079 -87.671 1.00 37.56 ? 578 THR A C 1 ATOM 4434 O O . THR A 1 547 ? 1.020 -9.380 -88.187 1.00 38.24 ? 578 THR A O 1 ATOM 4435 C CB . THR A 1 547 ? -2.259 -9.712 -88.649 1.00 40.26 ? 578 THR A CB 1 ATOM 4436 O OG1 . THR A 1 547 ? -2.835 -9.984 -87.366 1.00 40.42 ? 578 THR A OG1 1 ATOM 4437 C CG2 . THR A 1 547 ? -1.612 -10.979 -89.192 1.00 38.31 ? 578 THR A CG2 1 ATOM 4438 N N . SER A 1 548 ? -0.294 -9.163 -86.367 1.00 35.01 ? 579 SER A N 1 ATOM 4439 C CA . SER A 1 548 ? 0.721 -9.565 -85.405 1.00 31.97 ? 579 SER A CA 1 ATOM 4440 C C . SER A 1 548 ? 0.070 -9.770 -84.045 1.00 33.35 ? 579 SER A C 1 ATOM 4441 O O . SER A 1 548 ? -1.026 -9.272 -83.799 1.00 39.86 ? 579 SER A O 1 ATOM 4442 C CB . SER A 1 548 ? 1.830 -8.514 -85.312 1.00 32.41 ? 579 SER A CB 1 ATOM 4443 O OG . SER A 1 548 ? 2.699 -8.780 -84.226 1.00 37.14 ? 579 SER A OG 1 ATOM 4444 N N . PHE A 1 549 ? 0.743 -10.500 -83.164 1.00 30.81 ? 580 PHE A N 1 ATOM 4445 C CA . PHE A 1 549 ? 0.247 -10.697 -81.808 1.00 29.72 ? 580 PHE A CA 1 ATOM 4446 C C . PHE A 1 549 ? 0.714 -9.572 -80.883 1.00 34.85 ? 580 PHE A C 1 ATOM 4447 O O . PHE A 1 549 ? 0.390 -9.553 -79.695 1.00 33.55 ? 580 PHE A O 1 ATOM 4448 C CB . PHE A 1 549 ? 0.702 -12.052 -81.264 1.00 31.90 ? 580 PHE A CB 1 ATOM 4449 C CG . PHE A 1 549 ? -0.023 -13.224 -81.867 1.00 30.22 ? 580 PHE A CG 1 ATOM 4450 C CD1 . PHE A 1 549 ? -1.351 -13.117 -82.242 1.00 32.44 ? 580 PHE A CD1 1 ATOM 4451 C CD2 . PHE A 1 549 ? 0.625 -14.433 -82.059 1.00 28.55 ? 580 PHE A CD2 1 ATOM 4452 C CE1 . PHE A 1 549 ? -2.022 -14.193 -82.794 1.00 31.69 ? 580 PHE A CE1 1 ATOM 4453 C CE2 . PHE A 1 549 ? -0.039 -15.512 -82.612 1.00 31.56 ? 580 PHE A CE2 1 ATOM 4454 C CZ . PHE A 1 549 ? -1.363 -15.393 -82.981 1.00 29.00 ? 580 PHE A CZ 1 ATOM 4455 N N . ASN A 1 550 ? 1.464 -8.628 -81.445 1.00 32.74 ? 581 ASN A N 1 ATOM 4456 C CA . ASN A 1 550 ? 2.049 -7.536 -80.676 1.00 31.44 ? 581 ASN A CA 1 ATOM 4457 C C . ASN A 1 550 ? 1.696 -6.162 -81.257 1.00 34.03 ? 581 ASN A C 1 ATOM 4458 O O . ASN A 1 550 ? 1.982 -5.879 -82.421 1.00 35.79 ? 581 ASN A O 1 ATOM 4459 C CB . ASN A 1 550 ? 3.570 -7.704 -80.611 1.00 31.91 ? 581 ASN A CB 1 ATOM 4460 C CG . ASN A 1 550 ? 4.210 -6.861 -79.524 1.00 38.73 ? 581 ASN A CG 1 ATOM 4461 O OD1 . ASN A 1 550 ? 3.607 -5.917 -79.013 1.00 39.98 ? 581 ASN A OD1 1 ATOM 4462 N ND2 . ASN A 1 550 ? 5.444 -7.197 -79.169 1.00 37.73 ? 581 ASN A ND2 1 ATOM 4463 N N . VAL A 1 551 ? 1.081 -5.313 -80.437 1.00 31.33 ? 582 VAL A N 1 ATOM 4464 C CA . VAL A 1 551 ? 0.713 -3.961 -80.856 1.00 28.51 ? 582 VAL A CA 1 ATOM 4465 C C . VAL A 1 551 ? 1.938 -3.106 -81.163 1.00 37.63 ? 582 VAL A C 1 ATOM 4466 O O . VAL A 1 551 ? 1.853 -2.140 -81.919 1.00 41.29 ? 582 VAL A O 1 ATOM 4467 C CB . VAL A 1 551 ? -0.132 -3.231 -79.783 1.00 28.85 ? 582 VAL A CB 1 ATOM 4468 C CG1 . VAL A 1 551 ? -1.467 -3.915 -79.600 1.00 29.99 ? 582 VAL A CG1 1 ATOM 4469 C CG2 . VAL A 1 551 ? 0.619 -3.151 -78.461 1.00 31.29 ? 582 VAL A CG2 1 ATOM 4470 N N . GLN A 1 552 ? 3.074 -3.472 -80.577 1.00 36.55 ? 583 GLN A N 1 ATOM 4471 C CA . GLN A 1 552 ? 4.297 -2.686 -80.703 1.00 30.47 ? 583 GLN A CA 1 ATOM 4472 C C . GLN A 1 552 ? 4.957 -2.830 -82.073 1.00 39.69 ? 583 GLN A C 1 ATOM 4473 O O . GLN A 1 552 ? 5.803 -2.017 -82.444 1.00 45.88 ? 583 GLN A O 1 ATOM 4474 C CB . GLN A 1 552 ? 5.290 -3.086 -79.612 1.00 34.43 ? 583 GLN A CB 1 ATOM 4475 C CG . GLN A 1 552 ? 4.734 -2.975 -78.202 1.00 34.64 ? 583 GLN A CG 1 ATOM 4476 C CD . GLN A 1 552 ? 5.572 -3.715 -77.181 1.00 33.14 ? 583 GLN A CD 1 ATOM 4477 O OE1 . GLN A 1 552 ? 6.612 -4.290 -77.509 1.00 38.28 ? 583 GLN A OE1 1 ATOM 4478 N NE2 . GLN A 1 552 ? 5.120 -3.708 -75.933 1.00 30.26 ? 583 GLN A NE2 1 ATOM 4479 N N . ASP A 1 553 ? 4.575 -3.864 -82.817 1.00 43.64 ? 584 ASP A N 1 ATOM 4480 C CA . ASP A 1 553 ? 5.170 -4.124 -84.126 1.00 44.54 ? 584 ASP A CA 1 ATOM 4481 C C . ASP A 1 553 ? 4.769 -3.074 -85.162 1.00 50.19 ? 584 ASP A C 1 ATOM 4482 O O . ASP A 1 553 ? 3.581 -2.862 -85.410 1.00 47.60 ? 584 ASP A O 1 ATOM 4483 C CB . ASP A 1 553 ? 4.779 -5.517 -84.627 1.00 38.06 ? 584 ASP A CB 1 ATOM 4484 C CG . ASP A 1 553 ? 5.405 -6.631 -83.807 1.00 44.35 ? 584 ASP A CG 1 ATOM 4485 O OD1 . ASP A 1 553 ? 6.343 -6.348 -83.032 1.00 43.00 ? 584 ASP A OD1 1 ATOM 4486 O OD2 . ASP A 1 553 ? 4.966 -7.793 -83.944 1.00 45.71 ? 584 ASP A OD2 1 ATOM 4487 N N . PRO A 1 554 ? 5.767 -2.413 -85.769 1.00 49.32 ? 585 PRO A N 1 ATOM 4488 C CA . PRO A 1 554 ? 5.548 -1.404 -86.812 1.00 49.11 ? 585 PRO A CA 1 ATOM 4489 C C . PRO A 1 554 ? 5.080 -2.016 -88.132 1.00 51.36 ? 585 PRO A C 1 ATOM 4490 O O . PRO A 1 554 ? 5.598 -3.049 -88.555 1.00 49.61 ? 585 PRO A O 1 ATOM 4491 C CB . PRO A 1 554 ? 6.931 -0.754 -86.978 1.00 49.81 ? 585 PRO A CB 1 ATOM 4492 C CG . PRO A 1 554 ? 7.738 -1.205 -85.788 1.00 48.42 ? 585 PRO A CG 1 ATOM 4493 C CD . PRO A 1 554 ? 7.191 -2.542 -85.423 1.00 48.56 ? 585 PRO A CD 1 ATOM 4494 N N . GLN A 1 555 ? 4.108 -1.373 -88.770 1.00 56.06 ? 586 GLN A N 1 ATOM 4495 C CA . GLN A 1 555 ? 3.604 -1.817 -90.064 1.00 42.64 ? 586 GLN A CA 1 ATOM 4496 C C . GLN A 1 555 ? 4.329 -1.088 -91.198 1.00 61.10 ? 586 GLN A C 1 ATOM 4497 O O . GLN A 1 555 ? 4.278 0.139 -91.284 1.00 74.04 ? 586 GLN A O 1 ATOM 4498 C CB . GLN A 1 555 ? 2.094 -1.585 -90.151 1.00 39.46 ? 586 GLN A CB 1 ATOM 4499 C CG . GLN A 1 555 ? 1.478 -1.905 -91.503 1.00 51.48 ? 586 GLN A CG 1 ATOM 4500 C CD . GLN A 1 555 ? -0.030 -1.748 -91.499 1.00 62.01 ? 586 GLN A CD 1 ATOM 4501 O OE1 . GLN A 1 555 ? -0.655 -1.667 -90.440 1.00 67.54 ? 586 GLN A OE1 1 ATOM 4502 N NE2 . GLN A 1 555 ? -0.623 -1.703 -92.686 1.00 66.09 ? 586 GLN A NE2 1 ATOM 4503 N N . PRO A 1 556 ? 5.005 -1.848 -92.076 1.00 63.44 ? 587 PRO A N 1 ATOM 4504 C CA . PRO A 1 556 ? 5.859 -1.294 -93.137 1.00 51.44 ? 587 PRO A CA 1 ATOM 4505 C C . PRO A 1 556 ? 5.104 -0.478 -94.186 1.00 60.83 ? 587 PRO A C 1 ATOM 4506 O O . PRO A 1 556 ? 3.870 -0.485 -94.208 1.00 60.13 ? 587 PRO A O 1 ATOM 4507 C CB . PRO A 1 556 ? 6.477 -2.543 -93.773 1.00 43.14 ? 587 PRO A CB 1 ATOM 4508 C CG . PRO A 1 556 ? 5.523 -3.639 -93.463 1.00 47.89 ? 587 PRO A CG 1 ATOM 4509 C CD . PRO A 1 556 ? 4.968 -3.319 -92.110 1.00 56.54 ? 587 PRO A CD 1 ATOM 4510 N N . THR A 1 557 ? 5.860 0.210 -95.042 1.00 73.72 ? 588 THR A N 1 ATOM 4511 C CA . THR A 1 557 ? 5.312 1.064 -96.097 1.00 64.13 ? 588 THR A CA 1 ATOM 4512 C C . THR A 1 557 ? 4.397 2.145 -95.528 1.00 62.40 ? 588 THR A C 1 ATOM 4513 O O . THR A 1 557 ? 4.867 3.180 -95.053 1.00 51.13 ? 588 THR A O 1 ATOM 4514 C CB . THR A 1 557 ? 4.537 0.244 -97.154 1.00 74.25 ? 588 THR A CB 1 ATOM 4515 O OG1 . THR A 1 557 ? 5.449 -0.589 -97.882 1.00 66.53 ? 588 THR A OG1 1 ATOM 4516 C CG2 . THR A 1 557 ? 3.819 1.169 -98.129 1.00 65.34 ? 588 THR A CG2 1 HETATM 4517 C C1 . NAG B 2 . ? -16.338 -42.498 -66.917 1.00 37.45 ? 701 NAG A C1 1 HETATM 4518 C C2 . NAG B 2 . ? -17.367 -43.611 -67.023 1.00 61.97 ? 701 NAG A C2 1 HETATM 4519 C C3 . NAG B 2 . ? -18.767 -43.016 -67.056 1.00 43.51 ? 701 NAG A C3 1 HETATM 4520 C C4 . NAG B 2 . ? -18.986 -42.173 -65.806 1.00 46.71 ? 701 NAG A C4 1 HETATM 4521 C C5 . NAG B 2 . ? -17.875 -41.134 -65.646 1.00 41.84 ? 701 NAG A C5 1 HETATM 4522 C C6 . NAG B 2 . ? -17.924 -40.458 -64.298 1.00 44.66 ? 701 NAG A C6 1 HETATM 4523 C C7 . NAG B 2 . ? -17.122 -44.086 -69.443 1.00 48.55 ? 701 NAG A C7 1 HETATM 4524 C C8 . NAG B 2 . ? -16.870 -45.162 -70.457 1.00 35.37 ? 701 NAG A C8 1 HETATM 4525 N N2 . NAG B 2 . ? -17.134 -44.484 -68.166 1.00 47.67 ? 701 NAG A N2 1 HETATM 4526 O O3 . NAG B 2 . ? -19.737 -44.055 -67.121 1.00 73.20 ? 701 NAG A O3 1 HETATM 4527 O O4 . NAG B 2 . ? -20.241 -41.505 -65.867 1.00 57.36 ? 701 NAG A O4 1 HETATM 4528 O O5 . NAG B 2 . ? -16.577 -41.746 -65.731 1.00 41.33 ? 701 NAG A O5 1 HETATM 4529 O O6 . NAG B 2 . ? -17.886 -41.423 -63.255 1.00 38.43 ? 701 NAG A O6 1 HETATM 4530 O O7 . NAG B 2 . ? -17.303 -42.914 -69.770 1.00 58.33 ? 701 NAG A O7 1 HETATM 4531 C C1 . NAG C 2 . ? -21.140 -42.066 -64.891 1.00 60.85 ? 702 NAG A C1 1 HETATM 4532 C C2 . NAG C 2 . ? -22.082 -40.957 -64.397 1.00 57.38 ? 702 NAG A C2 1 HETATM 4533 C C3 . NAG C 2 . ? -23.160 -41.532 -63.475 1.00 65.41 ? 702 NAG A C3 1 HETATM 4534 C C4 . NAG C 2 . ? -23.849 -42.729 -64.116 1.00 73.89 ? 702 NAG A C4 1 HETATM 4535 C C5 . NAG C 2 . ? -22.804 -43.750 -64.543 1.00 65.83 ? 702 NAG A C5 1 HETATM 4536 C C6 . NAG C 2 . ? -23.395 -44.948 -65.249 1.00 65.68 ? 702 NAG A C6 1 HETATM 4537 C C7 . NAG C 2 . ? -21.149 -38.687 -64.211 1.00 52.35 ? 702 NAG A C7 1 HETATM 4538 C C8 . NAG C 2 . ? -20.361 -37.743 -63.354 1.00 37.57 ? 702 NAG A C8 1 HETATM 4539 N N2 . NAG C 2 . ? -21.339 -39.914 -63.711 1.00 49.88 ? 702 NAG A N2 1 HETATM 4540 O O3 . NAG C 2 . ? -24.119 -40.517 -63.200 1.00 69.66 ? 702 NAG A O3 1 HETATM 4541 O O4 . NAG C 2 . ? -24.756 -43.328 -63.197 1.00 73.88 ? 702 NAG A O4 1 HETATM 4542 O O5 . NAG C 2 . ? -21.900 -43.129 -65.466 1.00 80.17 ? 702 NAG A O5 1 HETATM 4543 O O6 . NAG C 2 . ? -22.478 -45.499 -66.185 1.00 62.83 ? 702 NAG A O6 1 HETATM 4544 O O7 . NAG C 2 . ? -21.591 -38.357 -65.307 1.00 57.43 ? 702 NAG A O7 1 HETATM 4545 C C1 . BOG D 3 . ? 13.630 -25.206 -67.948 1.00 53.00 ? 703 BOG A C1 1 HETATM 4546 O O1 . BOG D 3 . ? 14.192 -24.987 -69.206 1.00 55.99 ? 703 BOG A O1 1 HETATM 4547 C C2 . BOG D 3 . ? 13.308 -26.669 -67.751 1.00 52.95 ? 703 BOG A C2 1 HETATM 4548 O O2 . BOG D 3 . ? 12.374 -27.048 -68.672 1.00 55.69 ? 703 BOG A O2 1 HETATM 4549 C C3 . BOG D 3 . ? 12.792 -26.931 -66.342 1.00 58.84 ? 703 BOG A C3 1 HETATM 4550 O O3 . BOG D 3 . ? 12.774 -28.292 -66.105 1.00 57.17 ? 703 BOG A O3 1 HETATM 4551 C C4 . BOG D 3 . ? 13.641 -26.248 -65.322 1.00 69.11 ? 703 BOG A C4 1 HETATM 4552 O O4 . BOG D 3 . ? 13.021 -26.266 -64.060 1.00 61.86 ? 703 BOG A O4 1 HETATM 4553 C C5 . BOG D 3 . ? 13.905 -24.831 -65.745 1.00 60.54 ? 703 BOG A C5 1 HETATM 4554 O O5 . BOG D 3 . ? 14.519 -24.771 -66.995 1.00 62.26 ? 703 BOG A O5 1 HETATM 4555 C C6 . BOG D 3 . ? 14.820 -24.171 -64.770 1.00 54.83 ? 703 BOG A C6 1 HETATM 4556 O O6 . BOG D 3 . ? 16.086 -24.678 -64.919 1.00 56.63 ? 703 BOG A O6 1 HETATM 4557 C "C1'" . BOG D 3 . ? 13.459 -24.300 -70.180 1.00 51.23 ? 703 BOG A "C1'" 1 HETATM 4558 C "C2'" . BOG D 3 . ? 14.399 -23.400 -70.986 1.00 54.11 ? 703 BOG A "C2'" 1 HETATM 4559 C "C3'" . BOG D 3 . ? 15.709 -24.119 -71.243 1.00 49.99 ? 703 BOG A "C3'" 1 HETATM 4560 C "C4'" . BOG D 3 . ? 16.447 -23.418 -72.403 1.00 50.69 ? 703 BOG A "C4'" 1 HETATM 4561 C "C5'" . BOG D 3 . ? 17.946 -23.219 -72.039 1.00 55.21 ? 703 BOG A "C5'" 1 HETATM 4562 C "C6'" . BOG D 3 . ? 18.651 -22.497 -73.188 1.00 59.74 ? 703 BOG A "C6'" 1 HETATM 4563 C "C7'" . BOG D 3 . ? 20.108 -22.221 -72.813 1.00 59.54 ? 703 BOG A "C7'" 1 HETATM 4564 C "C8'" . BOG D 3 . ? 20.157 -21.240 -71.645 1.00 55.97 ? 703 BOG A "C8'" 1 HETATM 4565 C C1 . NAG E 2 . ? 9.176 -36.972 -43.016 1.00 60.26 ? 704 NAG A C1 1 HETATM 4566 C C2 . NAG E 2 . ? 10.242 -36.693 -41.951 1.00 60.73 ? 704 NAG A C2 1 HETATM 4567 C C3 . NAG E 2 . ? 9.623 -36.714 -40.554 1.00 70.41 ? 704 NAG A C3 1 HETATM 4568 C C4 . NAG E 2 . ? 8.420 -35.784 -40.487 1.00 83.37 ? 704 NAG A C4 1 HETATM 4569 C C5 . NAG E 2 . ? 7.430 -36.146 -41.590 1.00 75.42 ? 704 NAG A C5 1 HETATM 4570 C C6 . NAG E 2 . ? 6.233 -35.223 -41.650 1.00 58.91 ? 704 NAG A C6 1 HETATM 4571 C C7 . NAG E 2 . ? 12.586 -37.317 -42.352 1.00 63.52 ? 704 NAG A C7 1 HETATM 4572 C C8 . NAG E 2 . ? 13.576 -38.441 -42.395 1.00 50.17 ? 704 NAG A C8 1 HETATM 4573 N N2 . NAG E 2 . ? 11.329 -37.654 -42.041 1.00 59.16 ? 704 NAG A N2 1 HETATM 4574 O O3 . NAG E 2 . ? 10.602 -36.312 -39.603 1.00 70.12 ? 704 NAG A O3 1 HETATM 4575 O O4 . NAG E 2 . ? 7.795 -35.886 -39.212 1.00 79.17 ? 704 NAG A O4 1 HETATM 4576 O O5 . NAG E 2 . ? 8.088 -36.056 -42.862 1.00 63.95 ? 704 NAG A O5 1 HETATM 4577 O O6 . NAG E 2 . ? 5.991 -34.758 -42.971 1.00 63.63 ? 704 NAG A O6 1 HETATM 4578 O O7 . NAG E 2 . ? 12.908 -36.158 -42.588 1.00 68.27 ? 704 NAG A O7 1 HETATM 4579 C C1 . NAG F 2 . ? -25.429 -5.455 -82.665 1.00 83.30 ? 705 NAG A C1 1 HETATM 4580 C C2 . NAG F 2 . ? -26.368 -4.697 -81.728 1.00 95.41 ? 705 NAG A C2 1 HETATM 4581 C C3 . NAG F 2 . ? -27.258 -3.749 -82.529 1.00 97.20 ? 705 NAG A C3 1 HETATM 4582 C C4 . NAG F 2 . ? -26.412 -2.849 -83.421 1.00 99.80 ? 705 NAG A C4 1 HETATM 4583 C C5 . NAG F 2 . ? -25.474 -3.693 -84.280 1.00 88.23 ? 705 NAG A C5 1 HETATM 4584 C C6 . NAG F 2 . ? -24.522 -2.864 -85.111 1.00 86.75 ? 705 NAG A C6 1 HETATM 4585 C C7 . NAG F 2 . ? -27.127 -5.672 -79.607 1.00 100.47 ? 705 NAG A C7 1 HETATM 4586 C C8 . NAG F 2 . ? -28.026 -6.682 -78.960 1.00 98.00 ? 705 NAG A C8 1 HETATM 4587 N N2 . NAG F 2 . ? -27.175 -5.616 -80.942 1.00 97.89 ? 705 NAG A N2 1 HETATM 4588 O O3 . NAG F 2 . ? -28.032 -2.958 -81.634 1.00 94.45 ? 705 NAG A O3 1 HETATM 4589 O O4 . NAG F 2 . ? -27.250 -2.063 -84.260 1.00 88.88 ? 705 NAG A O4 1 HETATM 4590 O O5 . NAG F 2 . ? -24.667 -4.528 -83.437 1.00 81.48 ? 705 NAG A O5 1 HETATM 4591 O O6 . NAG F 2 . ? -23.752 -3.678 -85.985 1.00 74.18 ? 705 NAG A O6 1 HETATM 4592 O O7 . NAG F 2 . ? -26.391 -4.941 -78.951 1.00 89.85 ? 705 NAG A O7 1 HETATM 4593 C C1 . IBP G 4 . ? 9.183 -22.418 -72.525 1.00 48.84 ? 706 IBP A C1 1 HETATM 4594 C C2 . IBP G 4 . ? 2.973 -20.499 -72.699 1.00 30.79 ? 706 IBP A C2 1 HETATM 4595 C C3 . IBP G 4 . ? 2.444 -21.209 -71.500 1.00 38.16 ? 706 IBP A C3 1 HETATM 4596 C C4 . IBP G 4 . ? 2.715 -20.396 -70.282 1.00 39.33 ? 706 IBP A C4 1 HETATM 4597 C C5 . IBP G 4 . ? 0.970 -21.379 -71.658 1.00 36.37 ? 706 IBP A C5 1 HETATM 4598 C C6 . IBP G 4 . ? 8.590 -21.520 -73.561 1.00 37.57 ? 706 IBP A C6 1 HETATM 4599 C C7 . IBP G 4 . ? 8.793 -22.119 -74.914 1.00 34.30 ? 706 IBP A C7 1 HETATM 4600 C C8 . IBP G 4 . ? 7.130 -21.284 -73.334 1.00 31.61 ? 706 IBP A C8 1 HETATM 4601 C C9 . IBP G 4 . ? 6.713 -20.075 -72.804 1.00 28.56 ? 706 IBP A C9 1 HETATM 4602 C C10 . IBP G 4 . ? 5.365 -19.831 -72.599 1.00 35.24 ? 706 IBP A C10 1 HETATM 4603 C C11 . IBP G 4 . ? 4.421 -20.794 -72.924 1.00 38.06 ? 706 IBP A C11 1 HETATM 4604 C C12 . IBP G 4 . ? 4.833 -22.005 -73.465 1.00 35.96 ? 706 IBP A C12 1 HETATM 4605 C C13 . IBP G 4 . ? 6.187 -22.248 -73.668 1.00 35.24 ? 706 IBP A C13 1 HETATM 4606 O O1 . IBP G 4 . ? 9.992 -21.949 -71.679 1.00 48.03 ? 706 IBP A O1 1 HETATM 4607 O O2 . IBP G 4 . ? 8.890 -23.644 -72.501 1.00 54.71 ? 706 IBP A O2 1 HETATM 4608 O O . HOH H 5 . ? 8.560 -36.122 -82.838 1.00 28.95 ? 801 HOH A O 1 HETATM 4609 O O . HOH H 5 . ? -7.627 -36.393 -91.194 1.00 34.02 ? 802 HOH A O 1 HETATM 4610 O O . HOH H 5 . ? 6.105 -13.927 -69.829 1.00 38.42 ? 803 HOH A O 1 HETATM 4611 O O . HOH H 5 . ? -1.997 -28.916 -50.661 1.00 42.27 ? 804 HOH A O 1 HETATM 4612 O O . HOH H 5 . ? -2.065 -6.676 -63.195 1.00 40.64 ? 805 HOH A O 1 HETATM 4613 O O . HOH H 5 . ? 8.069 -26.543 -89.430 1.00 35.67 ? 806 HOH A O 1 HETATM 4614 O O . HOH H 5 . ? 1.532 -34.893 -65.288 1.00 37.43 ? 807 HOH A O 1 HETATM 4615 O O . HOH H 5 . ? -10.224 -32.258 -73.627 1.00 35.80 ? 808 HOH A O 1 HETATM 4616 O O . HOH H 5 . ? 2.942 -2.332 -75.267 1.00 36.04 ? 809 HOH A O 1 HETATM 4617 O O . HOH H 5 . ? -6.912 -2.364 -61.351 1.00 44.93 ? 810 HOH A O 1 HETATM 4618 O O . HOH H 5 . ? 6.570 -10.013 -80.214 1.00 31.28 ? 811 HOH A O 1 HETATM 4619 O O . HOH H 5 . ? -22.110 -24.327 -99.072 1.00 35.75 ? 812 HOH A O 1 HETATM 4620 O O . HOH H 5 . ? -9.235 -40.325 -103.361 1.00 28.18 ? 813 HOH A O 1 HETATM 4621 O O . HOH H 5 . ? 3.036 -25.190 -101.013 1.00 31.49 ? 814 HOH A O 1 HETATM 4622 O O . HOH H 5 . ? 9.108 -28.462 -82.183 1.00 28.48 ? 815 HOH A O 1 HETATM 4623 O O . HOH H 5 . ? -17.935 -4.274 -95.045 1.00 37.24 ? 816 HOH A O 1 HETATM 4624 O O . HOH H 5 . ? -15.545 -8.040 -101.677 1.00 50.25 ? 817 HOH A O 1 HETATM 4625 O O . HOH H 5 . ? -1.000 -27.193 -76.122 1.00 37.09 ? 818 HOH A O 1 HETATM 4626 O O . HOH H 5 . ? 9.929 -13.139 -78.562 1.00 36.28 ? 819 HOH A O 1 HETATM 4627 O O . HOH H 5 . ? -2.699 -45.121 -50.034 1.00 36.52 ? 820 HOH A O 1 HETATM 4628 O O . HOH H 5 . ? -2.769 -32.732 -80.069 1.00 32.30 ? 821 HOH A O 1 HETATM 4629 O O . HOH H 5 . ? -3.435 -4.249 -89.787 1.00 38.89 ? 822 HOH A O 1 HETATM 4630 O O . HOH H 5 . ? -7.321 -9.577 -101.200 1.00 46.92 ? 823 HOH A O 1 HETATM 4631 O O . HOH H 5 . ? 9.526 -31.603 -60.536 1.00 34.12 ? 824 HOH A O 1 HETATM 4632 O O . HOH H 5 . ? -3.648 -34.020 -49.226 1.00 44.61 ? 825 HOH A O 1 HETATM 4633 O O . HOH H 5 . ? 6.284 -22.050 -47.404 1.00 40.39 ? 826 HOH A O 1 HETATM 4634 O O . HOH H 5 . ? 7.416 -13.919 -60.497 1.00 37.63 ? 827 HOH A O 1 HETATM 4635 O O . HOH H 5 . ? -9.592 -45.528 -72.899 1.00 32.42 ? 828 HOH A O 1 HETATM 4636 O O . HOH H 5 . ? 8.394 -42.919 -57.603 1.00 35.52 ? 829 HOH A O 1 HETATM 4637 O O . HOH H 5 . ? 6.810 -37.663 -73.196 1.00 46.53 ? 830 HOH A O 1 HETATM 4638 O O . HOH H 5 . ? 8.376 -17.019 -70.677 1.00 43.30 ? 831 HOH A O 1 HETATM 4639 O O . HOH H 5 . ? -5.865 -39.461 -65.818 1.00 27.96 ? 832 HOH A O 1 HETATM 4640 O O . HOH H 5 . ? 6.840 -44.053 -43.258 1.00 44.07 ? 833 HOH A O 1 HETATM 4641 O O . HOH H 5 . ? 10.399 -40.713 -81.191 1.00 41.02 ? 834 HOH A O 1 HETATM 4642 O O . HOH H 5 . ? -4.784 -9.937 -62.656 1.00 45.05 ? 835 HOH A O 1 HETATM 4643 O O . HOH H 5 . ? -19.192 -20.176 -58.319 1.00 38.58 ? 836 HOH A O 1 HETATM 4644 O O . HOH H 5 . ? 15.116 -46.194 -58.058 1.00 40.21 ? 837 HOH A O 1 HETATM 4645 O O . HOH H 5 . ? 9.695 -18.406 -84.302 1.00 38.56 ? 838 HOH A O 1 HETATM 4646 O O . HOH H 5 . ? -18.791 -9.115 -96.369 1.00 42.81 ? 839 HOH A O 1 HETATM 4647 O O . HOH H 5 . ? 2.421 -6.761 -46.720 1.00 49.80 ? 840 HOH A O 1 HETATM 4648 O O . HOH H 5 . ? 7.790 -29.848 -98.644 1.00 34.13 ? 841 HOH A O 1 HETATM 4649 O O . HOH H 5 . ? 3.785 -9.982 -88.273 1.00 48.32 ? 842 HOH A O 1 HETATM 4650 O O . HOH H 5 . ? -17.766 -35.278 -76.628 1.00 43.25 ? 843 HOH A O 1 HETATM 4651 O O . HOH H 5 . ? -21.531 -4.271 -70.738 1.00 44.77 ? 844 HOH A O 1 HETATM 4652 O O . HOH H 5 . ? 12.265 -35.832 -58.576 1.00 36.69 ? 845 HOH A O 1 HETATM 4653 O O . HOH H 5 . ? -7.810 -39.256 -76.425 1.00 39.33 ? 846 HOH A O 1 HETATM 4654 O O . HOH H 5 . ? -11.315 -35.985 -53.363 1.00 42.44 ? 847 HOH A O 1 HETATM 4655 O O . HOH H 5 . ? 8.610 -43.586 -46.337 1.00 46.99 ? 848 HOH A O 1 HETATM 4656 O O . HOH H 5 . ? 8.481 -28.571 -96.498 1.00 39.33 ? 849 HOH A O 1 HETATM 4657 O O . HOH H 5 . ? -4.166 -43.537 -63.190 1.00 27.82 ? 850 HOH A O 1 HETATM 4658 O O . HOH H 5 . ? -6.522 -22.231 -103.513 1.00 38.01 ? 851 HOH A O 1 HETATM 4659 O O . HOH H 5 . ? 8.792 -13.178 -70.621 1.00 41.60 ? 852 HOH A O 1 HETATM 4660 O O . HOH H 5 . ? -3.358 -2.144 -87.857 1.00 50.26 ? 853 HOH A O 1 HETATM 4661 O O . HOH H 5 . ? 3.586 -11.966 -83.473 1.00 31.71 ? 854 HOH A O 1 HETATM 4662 O O . HOH H 5 . ? -16.685 -6.510 -95.638 1.00 44.21 ? 855 HOH A O 1 HETATM 4663 O O . HOH H 5 . ? -4.955 -36.416 -49.647 1.00 47.61 ? 856 HOH A O 1 HETATM 4664 O O . HOH H 5 . ? 5.608 -9.722 -82.732 1.00 36.31 ? 857 HOH A O 1 HETATM 4665 O O . HOH H 5 . ? 18.791 -21.564 -88.181 1.00 47.31 ? 858 HOH A O 1 HETATM 4666 O O . HOH H 5 . ? -5.669 -24.531 -55.032 1.00 40.96 ? 859 HOH A O 1 HETATM 4667 O O . HOH H 5 . ? -6.644 -38.424 -53.097 1.00 36.56 ? 860 HOH A O 1 HETATM 4668 O O . HOH H 5 . ? -6.839 -12.517 -99.792 1.00 46.37 ? 861 HOH A O 1 HETATM 4669 O O . HOH H 5 . ? 10.960 -21.782 -49.896 1.00 45.35 ? 862 HOH A O 1 HETATM 4670 O O . HOH H 5 . ? 10.496 -29.250 -90.813 1.00 41.30 ? 863 HOH A O 1 HETATM 4671 O O . HOH H 5 . ? 11.530 -26.858 -89.491 1.00 43.22 ? 864 HOH A O 1 HETATM 4672 O O . HOH H 5 . ? 0.433 -22.307 -51.120 1.00 36.57 ? 865 HOH A O 1 HETATM 4673 O O . HOH H 5 . ? -9.507 -34.107 -107.105 1.00 42.22 ? 866 HOH A O 1 HETATM 4674 O O . HOH H 5 . ? -15.709 -43.268 -62.476 1.00 32.82 ? 867 HOH A O 1 HETATM 4675 O O . HOH H 5 . ? -23.886 -31.829 -95.793 1.00 38.86 ? 868 HOH A O 1 HETATM 4676 O O . HOH H 5 . ? -11.214 -40.266 -101.925 1.00 32.91 ? 869 HOH A O 1 HETATM 4677 O O . HOH H 5 . ? 5.542 -13.775 -82.982 1.00 39.58 ? 870 HOH A O 1 HETATM 4678 O O . HOH H 5 . ? -17.569 -24.943 -103.877 1.00 38.73 ? 871 HOH A O 1 HETATM 4679 O O . HOH H 5 . ? 7.099 -14.591 -67.320 1.00 41.65 ? 872 HOH A O 1 HETATM 4680 O O . HOH H 5 . ? -3.886 1.054 -64.390 1.00 41.04 ? 873 HOH A O 1 HETATM 4681 O O . HOH H 5 . ? 1.750 -2.520 -67.670 1.00 43.09 ? 874 HOH A O 1 HETATM 4682 O O . HOH H 5 . ? -17.532 -39.707 -97.163 1.00 44.13 ? 875 HOH A O 1 HETATM 4683 O O . HOH H 5 . ? 1.192 -15.501 -62.771 1.00 31.25 ? 876 HOH A O 1 HETATM 4684 O O . HOH H 5 . ? -9.511 -32.169 -77.796 1.00 30.30 ? 877 HOH A O 1 HETATM 4685 O O . HOH H 5 . ? -12.063 -33.617 -78.955 1.00 36.75 ? 878 HOH A O 1 HETATM 4686 O O . HOH H 5 . ? -2.595 -30.760 -70.453 1.00 33.64 ? 879 HOH A O 1 HETATM 4687 O O . HOH H 5 . ? 10.380 -19.166 -66.843 1.00 37.83 ? 880 HOH A O 1 HETATM 4688 O O . HOH H 5 . ? -16.645 -32.484 -97.868 1.00 32.43 ? 881 HOH A O 1 HETATM 4689 O O . HOH H 5 . ? -0.954 -23.720 -75.627 1.00 31.01 ? 882 HOH A O 1 HETATM 4690 O O . HOH H 5 . ? -14.735 -34.601 -86.699 1.00 27.44 ? 883 HOH A O 1 HETATM 4691 O O . HOH H 5 . ? 2.479 -43.302 -76.636 0.50 31.83 ? 884 HOH A O 1 HETATM 4692 O O . HOH H 5 . ? -15.707 -32.798 -61.501 1.00 31.92 ? 885 HOH A O 1 HETATM 4693 O O . HOH H 5 . ? -7.243 -20.267 -83.937 1.00 32.20 ? 886 HOH A O 1 HETATM 4694 O O . HOH H 5 . ? -15.164 -10.399 -93.868 1.00 40.50 ? 887 HOH A O 1 HETATM 4695 O O . HOH H 5 . ? -14.181 -38.228 -91.129 1.00 34.60 ? 888 HOH A O 1 HETATM 4696 O O . HOH H 5 . ? -16.070 -24.410 -88.719 1.00 30.17 ? 889 HOH A O 1 HETATM 4697 O O . HOH H 5 . ? -18.909 -25.377 -92.694 1.00 38.28 ? 890 HOH A O 1 HETATM 4698 O O . HOH H 5 . ? -10.292 1.117 -66.834 1.00 39.45 ? 891 HOH A O 1 HETATM 4699 O O . HOH H 5 . ? -2.816 -38.802 -96.033 1.00 30.52 ? 892 HOH A O 1 HETATM 4700 O O . HOH H 5 . ? -11.291 -36.364 -89.806 1.00 38.60 ? 893 HOH A O 1 HETATM 4701 O O . HOH H 5 . ? -9.776 -32.398 -61.596 1.00 32.97 ? 894 HOH A O 1 HETATM 4702 O O . HOH H 5 . ? -14.737 -21.342 -99.794 1.00 29.36 ? 895 HOH A O 1 HETATM 4703 O O . HOH H 5 . ? 10.740 -25.440 -63.868 1.00 46.22 ? 896 HOH A O 1 HETATM 4704 O O . HOH H 5 . ? 2.167 -8.302 -57.616 1.00 37.04 ? 897 HOH A O 1 HETATM 4705 O O . HOH H 5 . ? -15.629 -39.244 -92.476 1.00 43.60 ? 898 HOH A O 1 HETATM 4706 O O . HOH H 5 . ? -6.871 -24.385 -85.729 1.00 28.69 ? 899 HOH A O 1 HETATM 4707 O O . HOH H 5 . ? -11.316 -43.793 -53.719 1.00 31.07 ? 900 HOH A O 1 HETATM 4708 O O . HOH H 5 . ? -10.338 -34.388 -63.378 1.00 30.41 ? 901 HOH A O 1 HETATM 4709 O O . HOH H 5 . ? -13.313 -4.606 -93.737 1.00 40.55 ? 902 HOH A O 1 HETATM 4710 O O . HOH H 5 . ? -10.322 -36.644 -81.835 1.00 32.58 ? 903 HOH A O 1 HETATM 4711 O O . HOH H 5 . ? -8.732 -18.206 -99.278 1.00 33.73 ? 904 HOH A O 1 HETATM 4712 O O . HOH H 5 . ? 1.649 -32.708 -53.231 1.00 38.31 ? 905 HOH A O 1 HETATM 4713 O O . HOH H 5 . ? -3.612 -38.198 -98.183 1.00 34.21 ? 906 HOH A O 1 HETATM 4714 O O . HOH H 5 . ? 0.915 -15.222 -98.139 1.00 31.87 ? 907 HOH A O 1 HETATM 4715 O O . HOH H 5 . ? -6.871 -22.904 -83.411 1.00 34.74 ? 908 HOH A O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 ALA 1 33 33 ALA ALA A . n A 1 2 ASN 2 34 34 ASN ASN A . n A 1 3 PRO 3 35 35 PRO PRO A . n A 1 4 CYS 4 36 36 CYS CYS A . n A 1 5 CYS 5 37 37 CYS CYS A . n A 1 6 SER 6 38 38 SER SER A . n A 1 7 ASN 7 39 39 ASN ASN A . n A 1 8 PRO 8 40 40 PRO PRO A . n A 1 9 CYS 9 41 41 CYS CYS A . n A 1 10 GLN 10 42 42 GLN GLN A . n A 1 11 ASN 11 43 43 ASN ASN A . n A 1 12 ARG 12 44 44 ARG ARG A . n A 1 13 GLY 13 45 45 GLY GLY A . n A 1 14 GLU 14 46 46 GLU GLU A . n A 1 15 CYS 15 47 47 CYS CYS A . n A 1 16 MET 16 48 48 MET MET A . n A 1 17 SER 17 49 49 SER SER A . n A 1 18 THR 18 50 50 THR THR A . n A 1 19 GLY 19 51 51 GLY GLY A . n A 1 20 PHE 20 52 52 PHE PHE A . n A 1 21 ASP 21 53 53 ASP ASP A . n A 1 22 GLN 22 54 54 GLN GLN A . n A 1 23 TYR 23 55 55 TYR TYR A . n A 1 24 LYS 24 56 56 LYS LYS A . n A 1 25 CYS 25 57 57 CYS CYS A . n A 1 26 ASP 26 58 58 ASP ASP A . n A 1 27 CYS 27 59 59 CYS CYS A . n A 1 28 THR 28 60 60 THR THR A . n A 1 29 ARG 29 61 61 ARG ARG A . n A 1 30 THR 30 62 62 THR THR A . n A 1 31 GLY 31 63 63 GLY GLY A . n A 1 32 PHE 32 64 64 PHE PHE A . n A 1 33 TYR 33 65 65 TYR TYR A . n A 1 34 GLY 34 66 66 GLY GLY A . n A 1 35 GLU 35 67 67 GLU GLU A . n A 1 36 ASN 36 68 68 ASN ASN A . n A 1 37 CYS 37 69 69 CYS CYS A . n A 1 38 THR 38 70 70 THR THR A . n A 1 39 THR 39 71 71 THR THR A . n A 1 40 PRO 40 72 72 PRO PRO A . n A 1 41 GLU 41 73 73 GLU GLU A . n A 1 42 PHE 42 74 74 PHE PHE A . n A 1 43 LEU 43 75 75 LEU LEU A . n A 1 44 THR 44 76 76 THR THR A . n A 1 45 ARG 45 77 77 ARG ARG A . n A 1 46 ILE 46 78 78 ILE ILE A . n A 1 47 LYS 47 79 79 LYS LYS A . n A 1 48 LEU 48 80 80 LEU LEU A . n A 1 49 LEU 49 81 81 LEU LEU A . n A 1 50 LEU 50 82 82 LEU LEU A . n A 1 51 LYS 51 83 83 LYS LYS A . n A 1 52 PRO 52 84 84 PRO PRO A . n A 1 53 THR 53 85 85 THR THR A . n A 1 54 PRO 54 86 86 PRO PRO A . n A 1 55 ASN 55 87 87 ASN ASN A . n A 1 56 THR 56 88 88 THR THR A . n A 1 57 VAL 57 89 89 VAL VAL A . n A 1 58 TRP 58 90 90 TRP TRP A . n A 1 59 TYR 59 91 91 TYR TYR A . n A 1 60 ILE 60 92 92 ILE ILE A . n A 1 61 LEU 61 93 93 LEU LEU A . n A 1 62 THR 62 94 94 THR THR A . n A 1 63 HIS 63 95 95 HIS HIS A . n A 1 64 PHE 64 96 96 PHE PHE A . n A 1 65 LYS 65 97 97 LYS LYS A . n A 1 66 GLY 66 98 98 GLY GLY A . n A 1 67 VAL 67 99 99 VAL VAL A . n A 1 68 TRP 68 100 100 TRP TRP A . n A 1 69 ASN 69 101 101 ASN ASN A . n A 1 70 ILE 70 102 102 ILE ILE A . n A 1 71 VAL 71 103 103 VAL VAL A . n A 1 72 ASN 72 104 104 ASN ASN A . n A 1 73 ASN 73 105 105 ASN ASN A . n A 1 74 ILE 74 105 105 ILE ILE A A n A 1 75 PRO 75 106 106 PRO PRO A . n A 1 76 PHE 76 107 107 PHE PHE A . n A 1 77 LEU 77 108 108 LEU LEU A . n A 1 78 ARG 78 109 109 ARG ARG A . n A 1 79 SER 79 110 110 SER SER A . n A 1 80 LEU 80 111 111 LEU LEU A . n A 1 81 ILE 81 112 112 ILE ILE A . n A 1 82 MET 82 113 113 MET MET A . n A 1 83 LYS 83 114 114 LYS LYS A . n A 1 84 TYR 84 115 115 TYR TYR A . n A 1 85 VAL 85 116 116 VAL VAL A . n A 1 86 LEU 86 117 117 LEU LEU A . n A 1 87 THR 87 118 118 THR THR A . n A 1 88 SER 88 119 119 SER SER A . n A 1 89 ARG 89 120 120 ARG ARG A . n A 1 90 SER 90 121 121 SER SER A . n A 1 91 TYR 91 122 122 TYR TYR A . n A 1 92 LEU 92 123 123 LEU LEU A . n A 1 93 ILE 93 124 124 ILE ILE A . n A 1 94 ASP 94 125 125 ASP ASP A . n A 1 95 SER 95 126 126 SER SER A . n A 1 96 PRO 96 127 127 PRO PRO A . n A 1 97 PRO 97 128 128 PRO PRO A . n A 1 98 THR 98 129 129 THR THR A . n A 1 99 TYR 99 130 130 TYR TYR A . n A 1 100 ASN 100 131 131 ASN ASN A . n A 1 101 VAL 101 132 132 VAL VAL A . n A 1 102 HIS 102 133 133 HIS HIS A . n A 1 103 TYR 103 134 134 TYR TYR A . n A 1 104 GLY 104 135 135 GLY GLY A . n A 1 105 TYR 105 136 136 TYR TYR A . n A 1 106 LYS 106 137 137 LYS LYS A . n A 1 107 SER 107 138 138 SER SER A . n A 1 108 TRP 108 139 139 TRP TRP A . n A 1 109 GLU 109 140 140 GLU GLU A . n A 1 110 ALA 110 141 141 ALA ALA A . n A 1 111 PHE 111 142 142 PHE PHE A . n A 1 112 SER 112 143 143 SER SER A . n A 1 113 ASN 113 144 144 ASN ASN A . n A 1 114 LEU 114 145 145 LEU LEU A . n A 1 115 SER 115 146 146 SER SER A . n A 1 116 TYR 116 147 147 TYR TYR A . n A 1 117 TYR 117 148 148 TYR TYR A . n A 1 118 THR 118 149 149 THR THR A . n A 1 119 ARG 119 150 150 ARG ARG A . n A 1 120 ALA 120 151 151 ALA ALA A . n A 1 121 LEU 121 152 152 LEU LEU A . n A 1 122 PRO 122 153 153 PRO PRO A . n A 1 123 PRO 123 154 154 PRO PRO A . n A 1 124 VAL 124 155 155 VAL VAL A . n A 1 125 ALA 125 156 156 ALA ALA A . n A 1 126 ASP 126 157 157 ASP ASP A . n A 1 127 ASP 127 158 158 ASP ASP A . n A 1 128 CYS 128 159 159 CYS CYS A . n A 1 129 PRO 129 160 160 PRO PRO A . n A 1 130 THR 130 161 161 THR THR A . n A 1 131 PRO 131 162 162 PRO PRO A . n A 1 132 MET 132 163 163 MET MET A . n A 1 133 GLY 133 164 164 GLY GLY A . n A 1 134 VAL 134 165 165 VAL VAL A . n A 1 135 LYS 135 166 166 LYS LYS A . n A 1 136 GLY 136 167 167 GLY GLY A . n A 1 137 ASN 137 168 168 ASN ASN A . n A 1 138 LYS 138 169 169 LYS LYS A . n A 1 139 GLU 139 170 170 GLU GLU A . n A 1 140 LEU 140 171 171 LEU LEU A . n A 1 141 PRO 141 172 172 PRO PRO A . n A 1 142 ASP 142 173 173 ASP ASP A . n A 1 143 SER 143 174 174 SER SER A . n A 1 144 LYS 144 175 175 LYS LYS A . n A 1 145 GLU 145 176 176 GLU GLU A . n A 1 146 VAL 146 177 177 VAL VAL A . n A 1 147 LEU 147 178 178 LEU LEU A . n A 1 148 GLU 148 179 179 GLU GLU A . n A 1 149 LYS 149 180 180 LYS LYS A . n A 1 150 VAL 150 181 181 VAL VAL A . n A 1 151 LEU 151 182 182 LEU LEU A . n A 1 152 LEU 152 183 183 LEU LEU A . n A 1 153 ARG 153 184 184 ARG ARG A . n A 1 154 ARG 154 185 185 ARG ARG A . n A 1 155 GLU 155 186 186 GLU GLU A . n A 1 156 PHE 156 187 187 PHE PHE A . n A 1 157 ILE 157 188 188 ILE ILE A . n A 1 158 PRO 158 189 189 PRO PRO A . n A 1 159 ASP 159 190 190 ASP ASP A . n A 1 160 PRO 160 191 191 PRO PRO A . n A 1 161 GLN 161 192 192 GLN GLN A . n A 1 162 GLY 162 193 193 GLY GLY A . n A 1 163 SER 163 194 194 SER SER A . n A 1 164 ASN 164 195 195 ASN ASN A . n A 1 165 MET 165 196 196 MET MET A . n A 1 166 MET 166 197 197 MET MET A . n A 1 167 PHE 167 198 198 PHE PHE A . n A 1 168 ALA 168 199 199 ALA ALA A . n A 1 169 PHE 169 200 200 PHE PHE A . n A 1 170 PHE 170 201 201 PHE PHE A . n A 1 171 ALA 171 202 202 ALA ALA A . n A 1 172 GLN 172 203 203 GLN GLN A . n A 1 173 HIS 173 204 204 HIS HIS A . n A 1 174 PHE 174 205 205 PHE PHE A . n A 1 175 THR 175 206 206 THR THR A . n A 1 176 HIS 176 207 207 HIS HIS A . n A 1 177 GLN 177 208 208 GLN GLN A . n A 1 178 PHE 178 209 209 PHE PHE A . n A 1 179 PHE 179 210 210 PHE PHE A . n A 1 180 LYS 180 211 211 LYS LYS A . n A 1 181 THR 181 212 212 THR THR A . n A 1 182 ASP 182 213 213 ASP ASP A . n A 1 183 HIS 183 214 214 HIS HIS A . n A 1 184 LYS 184 215 215 LYS LYS A . n A 1 185 ARG 185 216 216 ARG ARG A . n A 1 186 GLY 186 217 217 GLY GLY A . n A 1 187 PRO 187 218 218 PRO PRO A . n A 1 188 GLY 188 219 219 GLY GLY A . n A 1 189 PHE 189 220 220 PHE PHE A . n A 1 190 THR 190 221 221 THR THR A . n A 1 191 ARG 191 222 222 ARG ARG A . n A 1 192 GLY 192 223 223 GLY GLY A . n A 1 193 LEU 193 224 224 LEU LEU A . n A 1 194 GLY 194 225 225 GLY GLY A . n A 1 195 HIS 195 226 226 HIS HIS A . n A 1 196 GLY 196 227 227 GLY GLY A . n A 1 197 VAL 197 228 228 VAL VAL A . n A 1 198 ASP 198 229 229 ASP ASP A . n A 1 199 LEU 199 230 230 LEU LEU A . n A 1 200 ASN 200 231 231 ASN ASN A . n A 1 201 HIS 201 232 232 HIS HIS A . n A 1 202 ILE 202 233 233 ILE ILE A . n A 1 203 TYR 203 234 234 TYR TYR A . n A 1 204 GLY 204 235 235 GLY GLY A . n A 1 205 GLU 205 236 236 GLU GLU A . n A 1 206 THR 206 237 237 THR THR A . n A 1 207 LEU 207 238 238 LEU LEU A . n A 1 208 ASP 208 239 239 ASP ASP A . n A 1 209 ARG 209 240 240 ARG ARG A . n A 1 210 GLN 210 241 241 GLN GLN A . n A 1 211 HIS 211 242 242 HIS HIS A . n A 1 212 LYS 212 243 243 LYS LYS A . n A 1 213 LEU 213 244 244 LEU LEU A . n A 1 214 ARG 214 245 245 ARG ARG A . n A 1 215 LEU 215 246 246 LEU LEU A . n A 1 216 PHE 216 247 247 PHE PHE A . n A 1 217 LYS 217 248 248 LYS LYS A . n A 1 218 ASP 218 249 249 ASP ASP A . n A 1 219 GLY 219 250 250 GLY GLY A . n A 1 220 LYS 220 251 251 LYS LYS A . n A 1 221 LEU 221 252 252 LEU LEU A . n A 1 222 LYS 222 253 253 LYS LYS A . n A 1 223 TYR 223 254 254 TYR TYR A . n A 1 224 GLN 224 255 255 GLN GLN A . n A 1 225 VAL 225 256 256 VAL VAL A . n A 1 226 ILE 226 257 257 ILE ILE A . n A 1 227 GLY 227 258 258 GLY GLY A . n A 1 228 GLY 228 259 259 GLY GLY A . n A 1 229 GLU 229 260 260 GLU GLU A . n A 1 230 VAL 230 261 261 VAL VAL A . n A 1 231 TYR 231 262 262 TYR TYR A . n A 1 232 PRO 232 263 263 PRO PRO A . n A 1 233 PRO 233 264 264 PRO PRO A . n A 1 234 THR 234 265 265 THR THR A . n A 1 235 VAL 235 266 266 VAL VAL A . n A 1 236 LYS 236 267 267 LYS LYS A . n A 1 237 ASP 237 268 268 ASP ASP A . n A 1 238 THR 238 269 269 THR THR A . n A 1 239 GLN 239 270 270 GLN GLN A . n A 1 240 VAL 240 271 271 VAL VAL A . n A 1 241 GLU 241 272 272 GLU GLU A . n A 1 242 MET 242 273 273 MET MET A . n A 1 243 ILE 243 274 274 ILE ILE A . n A 1 244 TYR 244 275 275 TYR TYR A . n A 1 245 PRO 245 276 276 PRO PRO A . n A 1 246 PRO 246 277 277 PRO PRO A . n A 1 247 HIS 247 278 278 HIS HIS A . n A 1 248 ILE 248 279 279 ILE ILE A . n A 1 249 PRO 249 280 280 PRO PRO A . n A 1 250 GLU 250 281 281 GLU GLU A . n A 1 251 ASN 251 282 282 ASN ASN A . n A 1 252 LEU 252 283 283 LEU LEU A . n A 1 253 GLN 253 284 284 GLN GLN A . n A 1 254 PHE 254 285 285 PHE PHE A . n A 1 255 ALA 255 286 286 ALA ALA A . n A 1 256 VAL 256 287 287 VAL VAL A . n A 1 257 GLY 257 288 288 GLY GLY A . n A 1 258 GLN 258 289 289 GLN GLN A . n A 1 259 GLU 259 290 290 GLU GLU A . n A 1 260 VAL 260 291 291 VAL VAL A . n A 1 261 PHE 261 292 292 PHE PHE A . n A 1 262 GLY 262 293 293 GLY GLY A . n A 1 263 LEU 263 294 294 LEU LEU A . n A 1 264 VAL 264 295 295 VAL VAL A . n A 1 265 PRO 265 296 296 PRO PRO A . n A 1 266 GLY 266 297 297 GLY GLY A . n A 1 267 LEU 267 298 298 LEU LEU A . n A 1 268 MET 268 299 299 MET MET A . n A 1 269 MET 269 300 300 MET MET A . n A 1 270 TYR 270 301 301 TYR TYR A . n A 1 271 ALA 271 302 302 ALA ALA A . n A 1 272 THR 272 303 303 THR THR A . n A 1 273 ILE 273 304 304 ILE ILE A . n A 1 274 TRP 274 305 305 TRP TRP A . n A 1 275 LEU 275 306 306 LEU LEU A . n A 1 276 ARG 276 307 307 ARG ARG A . n A 1 277 GLU 277 308 308 GLU GLU A . n A 1 278 HIS 278 309 309 HIS HIS A . n A 1 279 ASN 279 310 310 ASN ASN A . n A 1 280 ARG 280 311 311 ARG ARG A . n A 1 281 VAL 281 312 312 VAL VAL A . n A 1 282 CYS 282 313 313 CYS CYS A . n A 1 283 ASP 283 314 314 ASP ASP A . n A 1 284 ILE 284 315 315 ILE ILE A . n A 1 285 LEU 285 316 316 LEU LEU A . n A 1 286 LYS 286 317 317 LYS LYS A . n A 1 287 GLN 287 318 318 GLN GLN A . n A 1 288 GLU 288 319 319 GLU GLU A . n A 1 289 HIS 289 320 320 HIS HIS A . n A 1 290 PRO 290 321 321 PRO PRO A . n A 1 291 GLU 291 322 322 GLU GLU A . n A 1 292 TRP 292 323 323 TRP TRP A . n A 1 293 GLY 293 324 324 GLY GLY A . n A 1 294 ASP 294 325 325 ASP ASP A . n A 1 295 GLU 295 326 326 GLU GLU A . n A 1 296 GLN 296 327 327 GLN GLN A . n A 1 297 LEU 297 328 328 LEU LEU A . n A 1 298 PHE 298 329 329 PHE PHE A . n A 1 299 GLN 299 330 330 GLN GLN A . n A 1 300 THR 300 331 331 THR THR A . n A 1 301 SER 301 332 332 SER SER A . n A 1 302 ARG 302 333 333 ARG ARG A . n A 1 303 LEU 303 334 334 LEU LEU A . n A 1 304 ILE 304 335 335 ILE ILE A . n A 1 305 LEU 305 336 336 LEU LEU A . n A 1 306 ILE 306 337 337 ILE ILE A . n A 1 307 GLY 307 338 338 GLY GLY A . n A 1 308 GLU 308 339 339 GLU GLU A . n A 1 309 THR 309 340 340 THR THR A . n A 1 310 ILE 310 341 341 ILE ILE A . n A 1 311 LYS 311 342 342 LYS LYS A . n A 1 312 ILE 312 343 343 ILE ILE A . n A 1 313 VAL 313 344 344 VAL VAL A . n A 1 314 ILE 314 345 345 ILE ILE A . n A 1 315 GLU 315 346 346 GLU GLU A . n A 1 316 ASP 316 347 347 ASP ASP A . n A 1 317 TYR 317 348 348 TYR TYR A . n A 1 318 VAL 318 349 349 VAL VAL A . n A 1 319 GLN 319 350 350 GLN GLN A . n A 1 320 HIS 320 351 351 HIS HIS A . n A 1 321 LEU 321 352 352 LEU LEU A . n A 1 322 SER 322 353 353 SER SER A . n A 1 323 GLY 323 354 354 GLY GLY A . n A 1 324 TYR 324 355 355 TYR TYR A . n A 1 325 HIS 325 356 356 HIS HIS A . n A 1 326 PHE 326 357 357 PHE PHE A . n A 1 327 LYS 327 358 358 LYS LYS A . n A 1 328 LEU 328 359 359 LEU LEU A . n A 1 329 LYS 329 360 360 LYS LYS A . n A 1 330 PHE 330 361 361 PHE PHE A . n A 1 331 ASP 331 362 362 ASP ASP A . n A 1 332 PRO 332 363 363 PRO PRO A . n A 1 333 GLU 333 364 364 GLU GLU A . n A 1 334 LEU 334 365 365 LEU LEU A . n A 1 335 LEU 335 366 366 LEU LEU A . n A 1 336 PHE 336 367 367 PHE PHE A . n A 1 337 ASN 337 368 368 ASN ASN A . n A 1 338 GLN 338 369 369 GLN GLN A . n A 1 339 GLN 339 370 370 GLN GLN A . n A 1 340 PHE 340 371 371 PHE PHE A . n A 1 341 GLN 341 372 372 GLN GLN A . n A 1 342 TYR 342 373 373 TYR TYR A . n A 1 343 GLN 343 374 374 GLN GLN A . n A 1 344 ASN 344 375 375 ASN ASN A . n A 1 345 ARG 345 376 376 ARG ARG A . n A 1 346 ILE 346 377 377 ILE ILE A . n A 1 347 ALA 347 378 378 ALA ALA A . n A 1 348 SER 348 379 379 SER SER A . n A 1 349 GLU 349 380 380 GLU GLU A . n A 1 350 PHE 350 381 381 PHE PHE A . n A 1 351 ASN 351 382 382 ASN ASN A . n A 1 352 THR 352 383 383 THR THR A . n A 1 353 LEU 353 384 384 LEU LEU A . n A 1 354 TYR 354 385 385 TYR TYR A . n A 1 355 HIS 355 386 386 HIS HIS A . n A 1 356 TRP 356 387 387 TRP TRP A . n A 1 357 HIS 357 388 388 HIS HIS A . n A 1 358 PRO 358 389 389 PRO PRO A . n A 1 359 LEU 359 390 390 LEU LEU A . n A 1 360 LEU 360 391 391 LEU LEU A . n A 1 361 PRO 361 392 392 PRO PRO A . n A 1 362 ASP 362 393 393 ASP ASP A . n A 1 363 THR 363 394 394 THR THR A . n A 1 364 PHE 364 395 395 PHE PHE A . n A 1 365 ASN 365 396 396 ASN ASN A . n A 1 366 ILE 366 397 397 ILE ILE A . n A 1 367 GLU 367 398 398 GLU GLU A . n A 1 368 ASP 368 399 399 ASP ASP A . n A 1 369 GLN 369 400 400 GLN GLN A . n A 1 370 GLU 370 401 401 GLU GLU A . n A 1 371 TYR 371 402 402 TYR TYR A . n A 1 372 SER 372 403 403 SER SER A . n A 1 373 PHE 373 404 404 PHE PHE A . n A 1 374 LYS 374 405 405 LYS LYS A . n A 1 375 GLN 375 406 406 GLN GLN A . n A 1 376 PHE 376 407 407 PHE PHE A . n A 1 377 LEU 377 408 408 LEU LEU A . n A 1 378 TYR 378 409 409 TYR TYR A . n A 1 379 ASN 379 410 410 ASN ASN A . n A 1 380 ASN 380 411 411 ASN ASN A . n A 1 381 SER 381 412 412 SER SER A . n A 1 382 ILE 382 413 413 ILE ILE A . n A 1 383 LEU 383 414 414 LEU LEU A . n A 1 384 LEU 384 415 415 LEU LEU A . n A 1 385 GLU 385 416 416 GLU GLU A . n A 1 386 HIS 386 417 417 HIS HIS A . n A 1 387 GLY 387 418 418 GLY GLY A . n A 1 388 LEU 388 419 419 LEU LEU A . n A 1 389 THR 389 420 420 THR THR A . n A 1 390 GLN 390 421 421 GLN GLN A . n A 1 391 PHE 391 422 422 PHE PHE A . n A 1 392 VAL 392 423 423 VAL VAL A . n A 1 393 GLU 393 424 424 GLU GLU A . n A 1 394 SER 394 425 425 SER SER A . n A 1 395 PHE 395 426 426 PHE PHE A . n A 1 396 THR 396 427 427 THR THR A . n A 1 397 ARG 397 428 428 ARG ARG A . n A 1 398 GLN 398 429 429 GLN GLN A . n A 1 399 ILE 399 430 430 ILE ILE A . n A 1 400 ALA 400 431 431 ALA ALA A . n A 1 401 GLY 401 432 432 GLY GLY A . n A 1 402 ARG 402 433 433 ARG ARG A . n A 1 403 VAL 403 434 434 VAL VAL A . n A 1 404 ALA 404 435 435 ALA ALA A . n A 1 405 GLY 405 436 436 GLY GLY A . n A 1 406 GLY 406 437 437 GLY GLY A . n A 1 407 ARG 407 438 438 ARG ARG A . n A 1 408 ASN 408 439 439 ASN ASN A . n A 1 409 VAL 409 440 440 VAL VAL A . n A 1 410 PRO 410 441 441 PRO PRO A . n A 1 411 ILE 411 442 442 ILE ILE A . n A 1 412 ALA 412 443 443 ALA ALA A . n A 1 413 VAL 413 444 444 VAL VAL A . n A 1 414 GLN 414 445 445 GLN GLN A . n A 1 415 ALA 415 446 446 ALA ALA A . n A 1 416 VAL 416 447 447 VAL VAL A . n A 1 417 ALA 417 448 448 ALA ALA A . n A 1 418 LYS 418 449 449 LYS LYS A . n A 1 419 ALA 419 450 450 ALA ALA A . n A 1 420 SER 420 451 451 SER SER A . n A 1 421 ILE 421 452 452 ILE ILE A . n A 1 422 ASP 422 453 453 ASP ASP A . n A 1 423 GLN 423 454 454 GLN GLN A . n A 1 424 SER 424 455 455 SER SER A . n A 1 425 ARG 425 456 456 ARG ARG A . n A 1 426 GLU 426 457 457 GLU GLU A . n A 1 427 MET 427 458 458 MET MET A . n A 1 428 LYS 428 459 459 LYS LYS A . n A 1 429 TYR 429 460 460 TYR TYR A . n A 1 430 GLN 430 461 461 GLN GLN A . n A 1 431 SER 431 462 462 SER SER A . n A 1 432 LEU 432 463 463 LEU LEU A . n A 1 433 ASN 433 464 464 ASN ASN A . n A 1 434 GLU 434 465 465 GLU GLU A . n A 1 435 TYR 435 466 466 TYR TYR A . n A 1 436 ARG 436 467 467 ARG ARG A . n A 1 437 LYS 437 468 468 LYS LYS A . n A 1 438 ARG 438 469 469 ARG ARG A . n A 1 439 PHE 439 470 470 PHE PHE A . n A 1 440 SER 440 471 471 SER SER A . n A 1 441 LEU 441 472 472 LEU LEU A . n A 1 442 LYS 442 473 473 LYS LYS A . n A 1 443 PRO 443 474 474 PRO PRO A . n A 1 444 TYR 444 475 475 TYR TYR A . n A 1 445 THR 445 476 476 THR THR A . n A 1 446 SER 446 477 477 SER SER A . n A 1 447 PHE 447 478 478 PHE PHE A . n A 1 448 GLU 448 479 479 GLU GLU A . n A 1 449 GLU 449 480 480 GLU GLU A . n A 1 450 LEU 450 481 481 LEU LEU A . n A 1 451 THR 451 482 482 THR THR A . n A 1 452 GLY 452 483 483 GLY GLY A . n A 1 453 GLU 453 484 484 GLU GLU A . n A 1 454 LYS 454 485 485 LYS LYS A . n A 1 455 GLU 455 486 486 GLU GLU A . n A 1 456 MET 456 487 487 MET MET A . n A 1 457 ALA 457 488 488 ALA ALA A . n A 1 458 ALA 458 489 489 ALA ALA A . n A 1 459 GLU 459 490 490 GLU GLU A . n A 1 460 LEU 460 491 491 LEU LEU A . n A 1 461 LYS 461 492 492 LYS LYS A . n A 1 462 ALA 462 493 493 ALA ALA A . n A 1 463 LEU 463 494 494 LEU LEU A . n A 1 464 TYR 464 495 495 TYR TYR A . n A 1 465 SER 465 496 496 SER SER A . n A 1 466 ASP 466 497 497 ASP ASP A . n A 1 467 ILE 467 498 498 ILE ILE A . n A 1 468 ASP 468 499 499 ASP ASP A . n A 1 469 VAL 469 500 500 VAL VAL A . n A 1 470 MET 470 501 501 MET MET A . n A 1 471 GLU 471 502 502 GLU GLU A . n A 1 472 LEU 472 503 503 LEU LEU A . n A 1 473 TYR 473 504 504 TYR TYR A . n A 1 474 PRO 474 505 505 PRO PRO A . n A 1 475 ALA 475 506 506 ALA ALA A . n A 1 476 LEU 476 507 507 LEU LEU A . n A 1 477 LEU 477 508 508 LEU LEU A . n A 1 478 VAL 478 509 509 VAL VAL A . n A 1 479 GLU 479 510 510 GLU GLU A . n A 1 480 LYS 480 511 511 LYS LYS A . n A 1 481 PRO 481 512 512 PRO PRO A . n A 1 482 ARG 482 513 513 ARG ARG A . n A 1 483 PRO 483 514 514 PRO PRO A . n A 1 484 ASP 484 515 515 ASP ASP A . n A 1 485 ALA 485 516 516 ALA ALA A . n A 1 486 ILE 486 517 517 ILE ILE A . n A 1 487 PHE 487 518 518 PHE PHE A . n A 1 488 GLY 488 519 519 GLY GLY A . n A 1 489 GLU 489 520 520 GLU GLU A . n A 1 490 THR 490 521 521 THR THR A . n A 1 491 MET 491 522 522 MET MET A . n A 1 492 VAL 492 523 523 VAL VAL A . n A 1 493 GLU 493 524 524 GLU GLU A . n A 1 494 LEU 494 525 525 LEU LEU A . n A 1 495 GLY 495 526 526 GLY GLY A . n A 1 496 ALA 496 527 527 ALA ALA A . n A 1 497 PRO 497 528 528 PRO PRO A . n A 1 498 PHE 498 529 529 PHE PHE A . n A 1 499 SER 499 530 530 SER SER A . n A 1 500 LEU 500 531 531 LEU LEU A . n A 1 501 LYS 501 532 532 LYS LYS A . n A 1 502 GLY 502 533 533 GLY GLY A . n A 1 503 LEU 503 534 534 LEU LEU A . n A 1 504 MET 504 535 535 MET MET A . n A 1 505 GLY 505 536 536 GLY GLY A . n A 1 506 ASN 506 537 537 ASN ASN A . n A 1 507 PRO 507 538 538 PRO PRO A . n A 1 508 ILE 508 539 539 ILE ILE A . n A 1 509 CYS 509 540 540 CYS CYS A . n A 1 510 SER 510 541 541 SER SER A . n A 1 511 PRO 511 542 542 PRO PRO A . n A 1 512 GLN 512 543 543 GLN GLN A . n A 1 513 TYR 513 544 544 TYR TYR A . n A 1 514 TRP 514 545 545 TRP TRP A . n A 1 515 LYS 515 546 546 LYS LYS A . n A 1 516 PRO 516 547 547 PRO PRO A . n A 1 517 SER 517 548 548 SER SER A . n A 1 518 THR 518 549 549 THR THR A . n A 1 519 PHE 519 550 550 PHE PHE A . n A 1 520 GLY 520 551 551 GLY GLY A . n A 1 521 GLY 521 552 552 GLY GLY A . n A 1 522 GLU 522 553 553 GLU GLU A . n A 1 523 VAL 523 554 554 VAL VAL A . n A 1 524 GLY 524 555 555 GLY GLY A . n A 1 525 PHE 525 556 556 PHE PHE A . n A 1 526 LYS 526 557 557 LYS LYS A . n A 1 527 ILE 527 558 558 ILE ILE A . n A 1 528 ILE 528 559 559 ILE ILE A . n A 1 529 ASN 529 560 560 ASN ASN A . n A 1 530 THR 530 561 561 THR THR A . n A 1 531 ALA 531 562 562 ALA ALA A . n A 1 532 SER 532 563 563 SER SER A . n A 1 533 ILE 533 564 564 ILE ILE A . n A 1 534 GLN 534 565 565 GLN GLN A . n A 1 535 SER 535 566 566 SER SER A . n A 1 536 LEU 536 567 567 LEU LEU A . n A 1 537 ILE 537 568 568 ILE ILE A . n A 1 538 CYS 538 569 569 CYS CYS A . n A 1 539 ASN 539 570 570 ASN ASN A . n A 1 540 ASN 540 571 571 ASN ASN A . n A 1 541 VAL 541 572 572 VAL VAL A . n A 1 542 LYS 542 573 573 LYS LYS A . n A 1 543 GLY 543 574 574 GLY GLY A . n A 1 544 CYS 544 575 575 CYS CYS A . n A 1 545 PRO 545 576 576 PRO PRO A . n A 1 546 PHE 546 577 577 PHE PHE A . n A 1 547 THR 547 578 578 THR THR A . n A 1 548 SER 548 579 579 SER SER A . n A 1 549 PHE 549 580 580 PHE PHE A . n A 1 550 ASN 550 581 581 ASN ASN A . n A 1 551 VAL 551 582 582 VAL VAL A . n A 1 552 GLN 552 583 583 GLN GLN A . n A 1 553 ASP 553 584 584 ASP ASP A . n A 1 554 PRO 554 585 585 PRO PRO A . n A 1 555 GLN 555 586 586 GLN GLN A . n A 1 556 PRO 556 587 587 PRO PRO A . n A 1 557 THR 557 588 588 THR THR A . n A 1 558 LYS 558 589 ? ? ? A . n A 1 559 THR 559 590 ? ? ? A . n A 1 560 ALA 560 591 ? ? ? A . n A 1 561 THR 561 592 ? ? ? A . n A 1 562 ILE 562 593 ? ? ? A . n A 1 563 ASN 563 594 ? ? ? A . n A 1 564 ALA 564 595 ? ? ? A . n A 1 565 SER 565 596 ? ? ? A . n A 1 566 ALA 566 597 ? ? ? A . n A 1 567 SER 567 598 ? ? ? A . n A 1 568 HIS 568 599 ? ? ? A . n A 1 569 SER 569 600 ? ? ? A . n A 1 570 ARG 570 601 ? ? ? A . n A 1 571 LEU 571 602 ? ? ? A . n A 1 572 ASP 572 603 ? ? ? A . n A 1 573 ASP 573 604 ? ? ? A . n A 1 574 ILE 574 605 ? ? ? A . n A 1 575 ASN 575 606 ? ? ? A . n A 1 576 PRO 576 607 ? ? ? A . n A 1 577 THR 577 608 ? ? ? A . n A 1 578 VAL 578 609 ? ? ? A . n A 1 579 LEU 579 610 ? ? ? A . n A 1 580 ILE 580 611 ? ? ? A . n A 1 581 LYS 581 612 ? ? ? A . n A 1 582 ARG 582 613 ? ? ? A . n A 1 583 ARG 583 614 ? ? ? A . n A 1 584 SER 584 615 ? ? ? A . n A 1 585 THR 585 616 ? ? ? A . n A 1 586 GLU 586 617 ? ? ? A . n A 1 587 LEU 587 618 ? ? ? A . n # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 36 A ASN 68 ? ASN 'GLYCOSYLATION SITE' 2 A ASN 113 A ASN 144 ? ASN 'GLYCOSYLATION SITE' 3 A ASN 379 A ASN 410 ? ASN 'GLYCOSYLATION SITE' # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_and_software_defined_assembly _pdbx_struct_assembly.method_details PISA _pdbx_struct_assembly.oligomeric_details dimeric _pdbx_struct_assembly.oligomeric_count 2 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1,2 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G,H # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 1 'ABSA (A^2)' 10590 ? 1 MORE 37 ? 1 'SSA (A^2)' 43140 ? # loop_ _pdbx_struct_oper_list.id _pdbx_struct_oper_list.type _pdbx_struct_oper_list.name _pdbx_struct_oper_list.symmetry_operation _pdbx_struct_oper_list.matrix[1][1] _pdbx_struct_oper_list.matrix[1][2] _pdbx_struct_oper_list.matrix[1][3] _pdbx_struct_oper_list.vector[1] _pdbx_struct_oper_list.matrix[2][1] _pdbx_struct_oper_list.matrix[2][2] _pdbx_struct_oper_list.matrix[2][3] _pdbx_struct_oper_list.vector[2] _pdbx_struct_oper_list.matrix[3][1] _pdbx_struct_oper_list.matrix[3][2] _pdbx_struct_oper_list.matrix[3][3] _pdbx_struct_oper_list.vector[3] 1 'identity operation' 1_555 x,y,z 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 2 'crystal symmetry operation' 6_544 x,-y-1/2,-z-3/4 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 -86.6035000000 0.0000000000 0.0000000000 -1.0000000000 -153.2730000000 # _pdbx_struct_special_symmetry.id 1 _pdbx_struct_special_symmetry.PDB_model_num 1 _pdbx_struct_special_symmetry.auth_asym_id A _pdbx_struct_special_symmetry.auth_comp_id HOH _pdbx_struct_special_symmetry.auth_seq_id 884 _pdbx_struct_special_symmetry.PDB_ins_code ? _pdbx_struct_special_symmetry.label_asym_id H _pdbx_struct_special_symmetry.label_comp_id HOH _pdbx_struct_special_symmetry.label_seq_id . # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2015-04-08 2 'Structure model' 1 1 2015-05-06 3 'Structure model' 1 2 2015-06-03 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Database references' 2 3 'Structure model' 'Database references' # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal HKL-2000 'data collection' . ? 1 PHASES phasing . ? 2 PHENIX refinement '(phenix.refine: 1.8.4_1496)' ? 3 HKL-2000 'data reduction' . ? 4 XDS 'data scaling' . ? 5 # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 THR A 129 ? ? -126.41 -96.10 2 1 PHE A 210 ? ? -111.77 70.17 3 1 LYS A 211 ? ? -116.56 77.41 4 1 ASP A 347 ? ? -126.36 -57.83 5 1 GLU A 398 ? ? 54.54 -114.94 6 1 ASN A 439 ? ? -141.08 13.53 7 1 SER A 496 ? ? 67.99 -55.08 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A LYS 589 ? A LYS 558 2 1 Y 1 A THR 590 ? A THR 559 3 1 Y 1 A ALA 591 ? A ALA 560 4 1 Y 1 A THR 592 ? A THR 561 5 1 Y 1 A ILE 593 ? A ILE 562 6 1 Y 1 A ASN 594 ? A ASN 563 7 1 Y 1 A ALA 595 ? A ALA 564 8 1 Y 1 A SER 596 ? A SER 565 9 1 Y 1 A ALA 597 ? A ALA 566 10 1 Y 1 A SER 598 ? A SER 567 11 1 Y 1 A HIS 599 ? A HIS 568 12 1 Y 1 A SER 600 ? A SER 569 13 1 Y 1 A ARG 601 ? A ARG 570 14 1 Y 1 A LEU 602 ? A LEU 571 15 1 Y 1 A ASP 603 ? A ASP 572 16 1 Y 1 A ASP 604 ? A ASP 573 17 1 Y 1 A ILE 605 ? A ILE 574 18 1 Y 1 A ASN 606 ? A ASN 575 19 1 Y 1 A PRO 607 ? A PRO 576 20 1 Y 1 A THR 608 ? A THR 577 21 1 Y 1 A VAL 609 ? A VAL 578 22 1 Y 1 A LEU 610 ? A LEU 579 23 1 Y 1 A ILE 611 ? A ILE 580 24 1 Y 1 A LYS 612 ? A LYS 581 25 1 Y 1 A ARG 613 ? A ARG 582 26 1 Y 1 A ARG 614 ? A ARG 583 27 1 Y 1 A SER 615 ? A SER 584 28 1 Y 1 A THR 616 ? A THR 585 29 1 Y 1 A GLU 617 ? A GLU 586 30 1 Y 1 A LEU 618 ? A LEU 587 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 B-OCTYLGLUCOSIDE BOG 4 IBUPROFEN IBP 5 water HOH # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code B 2 NAG 1 701 671 NAG NAG A . C 2 NAG 2 702 672 NAG NAG A . D 3 BOG 1 703 1 BOG BOG A . E 2 NAG 1 704 661 NAG NAG A . F 2 NAG 1 705 681 NAG NAG A . G 4 IBP 1 706 1 IBP IBP A . H 5 HOH 1 801 1 HOH HOH A . H 5 HOH 2 802 2 HOH HOH A . H 5 HOH 3 803 3 HOH HOH A . H 5 HOH 4 804 4 HOH HOH A . H 5 HOH 5 805 5 HOH HOH A . H 5 HOH 6 806 6 HOH HOH A . H 5 HOH 7 807 7 HOH HOH A . H 5 HOH 8 808 8 HOH HOH A . H 5 HOH 9 809 9 HOH HOH A . H 5 HOH 10 810 10 HOH HOH A . H 5 HOH 11 811 11 HOH HOH A . H 5 HOH 12 812 12 HOH HOH A . H 5 HOH 13 813 13 HOH HOH A . H 5 HOH 14 814 14 HOH HOH A . H 5 HOH 15 815 15 HOH HOH A . H 5 HOH 16 816 16 HOH HOH A . H 5 HOH 17 817 17 HOH HOH A . H 5 HOH 18 818 18 HOH HOH A . H 5 HOH 19 819 19 HOH HOH A . H 5 HOH 20 820 20 HOH HOH A . H 5 HOH 21 821 21 HOH HOH A . H 5 HOH 22 822 22 HOH HOH A . H 5 HOH 23 823 23 HOH HOH A . H 5 HOH 24 824 24 HOH HOH A . H 5 HOH 25 825 25 HOH HOH A . H 5 HOH 26 826 26 HOH HOH A . H 5 HOH 27 827 27 HOH HOH A . H 5 HOH 28 828 28 HOH HOH A . H 5 HOH 29 829 29 HOH HOH A . H 5 HOH 30 830 30 HOH HOH A . H 5 HOH 31 831 31 HOH HOH A . H 5 HOH 32 832 32 HOH HOH A . H 5 HOH 33 833 33 HOH HOH A . H 5 HOH 34 834 34 HOH HOH A . H 5 HOH 35 835 35 HOH HOH A . H 5 HOH 36 836 36 HOH HOH A . H 5 HOH 37 837 37 HOH HOH A . H 5 HOH 38 838 38 HOH HOH A . H 5 HOH 39 839 39 HOH HOH A . H 5 HOH 40 840 40 HOH HOH A . H 5 HOH 41 841 41 HOH HOH A . H 5 HOH 42 842 42 HOH HOH A . H 5 HOH 43 843 43 HOH HOH A . H 5 HOH 44 844 44 HOH HOH A . H 5 HOH 45 845 45 HOH HOH A . H 5 HOH 46 846 46 HOH HOH A . H 5 HOH 47 847 47 HOH HOH A . H 5 HOH 48 848 48 HOH HOH A . H 5 HOH 49 849 49 HOH HOH A . H 5 HOH 50 850 50 HOH HOH A . H 5 HOH 51 851 51 HOH HOH A . H 5 HOH 52 852 52 HOH HOH A . H 5 HOH 53 853 53 HOH HOH A . H 5 HOH 54 854 54 HOH HOH A . H 5 HOH 55 855 55 HOH HOH A . H 5 HOH 56 856 56 HOH HOH A . H 5 HOH 57 857 57 HOH HOH A . H 5 HOH 58 858 58 HOH HOH A . H 5 HOH 59 859 59 HOH HOH A . H 5 HOH 60 860 60 HOH HOH A . H 5 HOH 61 861 61 HOH HOH A . H 5 HOH 62 862 62 HOH HOH A . H 5 HOH 63 863 63 HOH HOH A . H 5 HOH 64 864 64 HOH HOH A . H 5 HOH 65 865 65 HOH HOH A . H 5 HOH 66 866 66 HOH HOH A . H 5 HOH 67 867 67 HOH HOH A . H 5 HOH 68 868 68 HOH HOH A . H 5 HOH 69 869 69 HOH HOH A . H 5 HOH 70 870 70 HOH HOH A . H 5 HOH 71 871 71 HOH HOH A . H 5 HOH 72 872 72 HOH HOH A . H 5 HOH 73 873 73 HOH HOH A . H 5 HOH 74 874 74 HOH HOH A . H 5 HOH 75 875 75 HOH HOH A . H 5 HOH 76 876 76 HOH HOH A . H 5 HOH 77 877 77 HOH HOH A . H 5 HOH 78 878 78 HOH HOH A . H 5 HOH 79 879 79 HOH HOH A . H 5 HOH 80 880 80 HOH HOH A . H 5 HOH 81 881 81 HOH HOH A . H 5 HOH 82 882 82 HOH HOH A . H 5 HOH 83 883 83 HOH HOH A . H 5 HOH 84 884 84 HOH HOH A . H 5 HOH 85 885 85 HOH HOH A . H 5 HOH 86 886 86 HOH HOH A . H 5 HOH 87 887 87 HOH HOH A . H 5 HOH 88 888 88 HOH HOH A . H 5 HOH 89 889 89 HOH HOH A . H 5 HOH 90 890 90 HOH HOH A . H 5 HOH 91 891 91 HOH HOH A . H 5 HOH 92 892 92 HOH HOH A . H 5 HOH 93 893 93 HOH HOH A . H 5 HOH 94 894 94 HOH HOH A . H 5 HOH 95 895 95 HOH HOH A . H 5 HOH 96 896 96 HOH HOH A . H 5 HOH 97 897 97 HOH HOH A . H 5 HOH 98 898 98 HOH HOH A . H 5 HOH 99 899 99 HOH HOH A . H 5 HOH 100 900 100 HOH HOH A . H 5 HOH 101 901 101 HOH HOH A . H 5 HOH 102 902 102 HOH HOH A . H 5 HOH 103 903 103 HOH HOH A . H 5 HOH 104 904 104 HOH HOH A . H 5 HOH 105 905 105 HOH HOH A . H 5 HOH 106 906 106 HOH HOH A . H 5 HOH 107 907 107 HOH HOH A . H 5 HOH 108 908 108 HOH HOH A . #