data_4PNX # _entry.id 4PNX # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 4PNX RCSB RCSB085003 WWPDB D_1000085003 # _pdbx_database_related.db_name PDB _pdbx_database_related.db_id 3OGW _pdbx_database_related.details 'Model pdb' _pdbx_database_related.content_type unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 4PNX _pdbx_database_status.recvd_initial_deposition_date 2014-02-22 _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site PDBJ _pdbx_database_status.methods_development_category ? _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry ? _pdbx_database_status.status_code_cs ? _pdbx_database_status.pdb_format_compatible Y # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Sirohi, H.V.' 1 'Tyagi, T.K.' 2 'Singh, A.K.' 3 'Sinha, M.' 4 'Bhushan, A.' 5 'Kaur, P.' 6 'Sharma, S.' 7 'Singh, T.P.' 8 # _citation.id primary _citation.title 'Structure of bovine lactoperoxidase with a partially linked heme moiety at 1.98 angstrom resolution.' _citation.journal_abbrev Biochim.Biophys.Acta _citation.journal_volume 1865 _citation.page_first 329 _citation.page_last 335 _citation.year 2017 _citation.journal_id_ASTM BBACAQ _citation.country NE _citation.journal_id_ISSN 0006-3002 _citation.journal_id_CSD 0113 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 27986533 _citation.pdbx_database_id_DOI 10.1016/j.bbapap.2016.12.006 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Singh, P.K.' 1 primary 'Sirohi, H.V.' 2 primary 'Iqbal, N.' 3 primary 'Tiwari, P.' 4 primary 'Kaur, P.' 5 primary 'Sharma, S.' 6 primary 'Singh, T.P.' 7 # _cell.entry_id 4PNX _cell.length_a 53.742 _cell.length_b 80.379 _cell.length_c 73.177 _cell.angle_alpha 90.00 _cell.angle_beta 103.50 _cell.angle_gamma 90.00 _cell.Z_PDB 2 _cell.pdbx_unique_axis ? _cell.length_a_esd ? _cell.length_b_esd ? _cell.length_c_esd ? _cell.angle_alpha_esd ? _cell.angle_beta_esd ? _cell.angle_gamma_esd ? # _symmetry.entry_id 4PNX _symmetry.space_group_name_H-M 'P 1 21 1' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 4 _symmetry.space_group_name_Hall ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer nat Lactoperoxidase 67853.281 1 1.11.1.7 ? 'UNP RESIDUES 118-712' ? 2 non-polymer syn 'CALCIUM ION' 40.078 1 ? ? ? ? 3 non-polymer syn 'PROTOPORPHYRIN IX CONTAINING FE' 616.487 1 ? ? ? ? 4 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 4 ? ? ? ? 5 non-polymer syn BROMOMETHANE 94.939 1 ? ? ? ? 6 non-polymer syn 'IODIDE ION' 126.904 13 ? ? ? ? 7 water nat water 18.015 111 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name LPO # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer yes _entity_poly.pdbx_seq_one_letter_code ;SWEVGCGAPVPLVKCDENSPYRTITGDCNNRRSPALGAANRALARWLPAEYEDGLALPFGWTQRKTRNGFRVPLAREVSN KIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELGSNEHSKTQCEEYCIQGDNCFPIMFPKNDPKLKTQGKCMPF FRAGFVCPTPPYQSLAREQINAVTSFLDASLVYGSEP(SEP)LASRLRNLSSPLGLMAVNQEAWDHGLAYLPFNNKKPSP CEFINTTARVPCFLAGDFRASEQILLATAHTLLLREHNRLARELKKLNPHWNGEKLYQEARKILGAFIQIITFRDYLPIV LGSEMQKWIPPYQGYNNSVDPRISNVFTFAFRFGHMEVPSTVSRLDENYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLV RGLLAKKSKLMNQDKMVTSELRNKLFQPTHKIHGFDLAAINLQRCRDHGMPGYNSWRGFCGLSQPKTLKGLQTVLKNKIL AKKLMDLYKTPDNIDIWIGGNAEPMVERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTEKQRDSLQKVSFSRLICDN THITKVPLHAFQANNYPHDFVDCSTVDKLDLSPWASREN ; _entity_poly.pdbx_seq_one_letter_code_can ;SWEVGCGAPVPLVKCDENSPYRTITGDCNNRRSPALGAANRALARWLPAEYEDGLALPFGWTQRKTRNGFRVPLAREVSN KIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELGSNEHSKTQCEEYCIQGDNCFPIMFPKNDPKLKTQGKCMPF FRAGFVCPTPPYQSLAREQINAVTSFLDASLVYGSEPSLASRLRNLSSPLGLMAVNQEAWDHGLAYLPFNNKKPSPCEFI NTTARVPCFLAGDFRASEQILLATAHTLLLREHNRLARELKKLNPHWNGEKLYQEARKILGAFIQIITFRDYLPIVLGSE MQKWIPPYQGYNNSVDPRISNVFTFAFRFGHMEVPSTVSRLDENYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLVRGLL AKKSKLMNQDKMVTSELRNKLFQPTHKIHGFDLAAINLQRCRDHGMPGYNSWRGFCGLSQPKTLKGLQTVLKNKILAKKL MDLYKTPDNIDIWIGGNAEPMVERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTEKQRDSLQKVSFSRLICDNTHIT KVPLHAFQANNYPHDFVDCSTVDKLDLSPWASREN ; _entity_poly.pdbx_strand_id A _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 SER n 1 2 TRP n 1 3 GLU n 1 4 VAL n 1 5 GLY n 1 6 CYS n 1 7 GLY n 1 8 ALA n 1 9 PRO n 1 10 VAL n 1 11 PRO n 1 12 LEU n 1 13 VAL n 1 14 LYS n 1 15 CYS n 1 16 ASP n 1 17 GLU n 1 18 ASN n 1 19 SER n 1 20 PRO n 1 21 TYR n 1 22 ARG n 1 23 THR n 1 24 ILE n 1 25 THR n 1 26 GLY n 1 27 ASP n 1 28 CYS n 1 29 ASN n 1 30 ASN n 1 31 ARG n 1 32 ARG n 1 33 SER n 1 34 PRO n 1 35 ALA n 1 36 LEU n 1 37 GLY n 1 38 ALA n 1 39 ALA n 1 40 ASN n 1 41 ARG n 1 42 ALA n 1 43 LEU n 1 44 ALA n 1 45 ARG n 1 46 TRP n 1 47 LEU n 1 48 PRO n 1 49 ALA n 1 50 GLU n 1 51 TYR n 1 52 GLU n 1 53 ASP n 1 54 GLY n 1 55 LEU n 1 56 ALA n 1 57 LEU n 1 58 PRO n 1 59 PHE n 1 60 GLY n 1 61 TRP n 1 62 THR n 1 63 GLN n 1 64 ARG n 1 65 LYS n 1 66 THR n 1 67 ARG n 1 68 ASN n 1 69 GLY n 1 70 PHE n 1 71 ARG n 1 72 VAL n 1 73 PRO n 1 74 LEU n 1 75 ALA n 1 76 ARG n 1 77 GLU n 1 78 VAL n 1 79 SER n 1 80 ASN n 1 81 LYS n 1 82 ILE n 1 83 VAL n 1 84 GLY n 1 85 TYR n 1 86 LEU n 1 87 ASP n 1 88 GLU n 1 89 GLU n 1 90 GLY n 1 91 VAL n 1 92 LEU n 1 93 ASP n 1 94 GLN n 1 95 ASN n 1 96 ARG n 1 97 SER n 1 98 LEU n 1 99 LEU n 1 100 PHE n 1 101 MET n 1 102 GLN n 1 103 TRP n 1 104 GLY n 1 105 GLN n 1 106 ILE n 1 107 VAL n 1 108 ASP n 1 109 HIS n 1 110 ASP n 1 111 LEU n 1 112 ASP n 1 113 PHE n 1 114 ALA n 1 115 PRO n 1 116 GLU n 1 117 THR n 1 118 GLU n 1 119 LEU n 1 120 GLY n 1 121 SER n 1 122 ASN n 1 123 GLU n 1 124 HIS n 1 125 SER n 1 126 LYS n 1 127 THR n 1 128 GLN n 1 129 CYS n 1 130 GLU n 1 131 GLU n 1 132 TYR n 1 133 CYS n 1 134 ILE n 1 135 GLN n 1 136 GLY n 1 137 ASP n 1 138 ASN n 1 139 CYS n 1 140 PHE n 1 141 PRO n 1 142 ILE n 1 143 MET n 1 144 PHE n 1 145 PRO n 1 146 LYS n 1 147 ASN n 1 148 ASP n 1 149 PRO n 1 150 LYS n 1 151 LEU n 1 152 LYS n 1 153 THR n 1 154 GLN n 1 155 GLY n 1 156 LYS n 1 157 CYS n 1 158 MET n 1 159 PRO n 1 160 PHE n 1 161 PHE n 1 162 ARG n 1 163 ALA n 1 164 GLY n 1 165 PHE n 1 166 VAL n 1 167 CYS n 1 168 PRO n 1 169 THR n 1 170 PRO n 1 171 PRO n 1 172 TYR n 1 173 GLN n 1 174 SER n 1 175 LEU n 1 176 ALA n 1 177 ARG n 1 178 GLU n 1 179 GLN n 1 180 ILE n 1 181 ASN n 1 182 ALA n 1 183 VAL n 1 184 THR n 1 185 SER n 1 186 PHE n 1 187 LEU n 1 188 ASP n 1 189 ALA n 1 190 SER n 1 191 LEU n 1 192 VAL n 1 193 TYR n 1 194 GLY n 1 195 SER n 1 196 GLU n 1 197 PRO n 1 198 SEP n 1 199 LEU n 1 200 ALA n 1 201 SER n 1 202 ARG n 1 203 LEU n 1 204 ARG n 1 205 ASN n 1 206 LEU n 1 207 SER n 1 208 SER n 1 209 PRO n 1 210 LEU n 1 211 GLY n 1 212 LEU n 1 213 MET n 1 214 ALA n 1 215 VAL n 1 216 ASN n 1 217 GLN n 1 218 GLU n 1 219 ALA n 1 220 TRP n 1 221 ASP n 1 222 HIS n 1 223 GLY n 1 224 LEU n 1 225 ALA n 1 226 TYR n 1 227 LEU n 1 228 PRO n 1 229 PHE n 1 230 ASN n 1 231 ASN n 1 232 LYS n 1 233 LYS n 1 234 PRO n 1 235 SER n 1 236 PRO n 1 237 CYS n 1 238 GLU n 1 239 PHE n 1 240 ILE n 1 241 ASN n 1 242 THR n 1 243 THR n 1 244 ALA n 1 245 ARG n 1 246 VAL n 1 247 PRO n 1 248 CYS n 1 249 PHE n 1 250 LEU n 1 251 ALA n 1 252 GLY n 1 253 ASP n 1 254 PHE n 1 255 ARG n 1 256 ALA n 1 257 SER n 1 258 GLU n 1 259 GLN n 1 260 ILE n 1 261 LEU n 1 262 LEU n 1 263 ALA n 1 264 THR n 1 265 ALA n 1 266 HIS n 1 267 THR n 1 268 LEU n 1 269 LEU n 1 270 LEU n 1 271 ARG n 1 272 GLU n 1 273 HIS n 1 274 ASN n 1 275 ARG n 1 276 LEU n 1 277 ALA n 1 278 ARG n 1 279 GLU n 1 280 LEU n 1 281 LYS n 1 282 LYS n 1 283 LEU n 1 284 ASN n 1 285 PRO n 1 286 HIS n 1 287 TRP n 1 288 ASN n 1 289 GLY n 1 290 GLU n 1 291 LYS n 1 292 LEU n 1 293 TYR n 1 294 GLN n 1 295 GLU n 1 296 ALA n 1 297 ARG n 1 298 LYS n 1 299 ILE n 1 300 LEU n 1 301 GLY n 1 302 ALA n 1 303 PHE n 1 304 ILE n 1 305 GLN n 1 306 ILE n 1 307 ILE n 1 308 THR n 1 309 PHE n 1 310 ARG n 1 311 ASP n 1 312 TYR n 1 313 LEU n 1 314 PRO n 1 315 ILE n 1 316 VAL n 1 317 LEU n 1 318 GLY n 1 319 SER n 1 320 GLU n 1 321 MET n 1 322 GLN n 1 323 LYS n 1 324 TRP n 1 325 ILE n 1 326 PRO n 1 327 PRO n 1 328 TYR n 1 329 GLN n 1 330 GLY n 1 331 TYR n 1 332 ASN n 1 333 ASN n 1 334 SER n 1 335 VAL n 1 336 ASP n 1 337 PRO n 1 338 ARG n 1 339 ILE n 1 340 SER n 1 341 ASN n 1 342 VAL n 1 343 PHE n 1 344 THR n 1 345 PHE n 1 346 ALA n 1 347 PHE n 1 348 ARG n 1 349 PHE n 1 350 GLY n 1 351 HIS n 1 352 MET n 1 353 GLU n 1 354 VAL n 1 355 PRO n 1 356 SER n 1 357 THR n 1 358 VAL n 1 359 SER n 1 360 ARG n 1 361 LEU n 1 362 ASP n 1 363 GLU n 1 364 ASN n 1 365 TYR n 1 366 GLN n 1 367 PRO n 1 368 TRP n 1 369 GLY n 1 370 PRO n 1 371 GLU n 1 372 ALA n 1 373 GLU n 1 374 LEU n 1 375 PRO n 1 376 LEU n 1 377 HIS n 1 378 THR n 1 379 LEU n 1 380 PHE n 1 381 PHE n 1 382 ASN n 1 383 THR n 1 384 TRP n 1 385 ARG n 1 386 ILE n 1 387 ILE n 1 388 LYS n 1 389 ASP n 1 390 GLY n 1 391 GLY n 1 392 ILE n 1 393 ASP n 1 394 PRO n 1 395 LEU n 1 396 VAL n 1 397 ARG n 1 398 GLY n 1 399 LEU n 1 400 LEU n 1 401 ALA n 1 402 LYS n 1 403 LYS n 1 404 SER n 1 405 LYS n 1 406 LEU n 1 407 MET n 1 408 ASN n 1 409 GLN n 1 410 ASP n 1 411 LYS n 1 412 MET n 1 413 VAL n 1 414 THR n 1 415 SER n 1 416 GLU n 1 417 LEU n 1 418 ARG n 1 419 ASN n 1 420 LYS n 1 421 LEU n 1 422 PHE n 1 423 GLN n 1 424 PRO n 1 425 THR n 1 426 HIS n 1 427 LYS n 1 428 ILE n 1 429 HIS n 1 430 GLY n 1 431 PHE n 1 432 ASP n 1 433 LEU n 1 434 ALA n 1 435 ALA n 1 436 ILE n 1 437 ASN n 1 438 LEU n 1 439 GLN n 1 440 ARG n 1 441 CYS n 1 442 ARG n 1 443 ASP n 1 444 HIS n 1 445 GLY n 1 446 MET n 1 447 PRO n 1 448 GLY n 1 449 TYR n 1 450 ASN n 1 451 SER n 1 452 TRP n 1 453 ARG n 1 454 GLY n 1 455 PHE n 1 456 CYS n 1 457 GLY n 1 458 LEU n 1 459 SER n 1 460 GLN n 1 461 PRO n 1 462 LYS n 1 463 THR n 1 464 LEU n 1 465 LYS n 1 466 GLY n 1 467 LEU n 1 468 GLN n 1 469 THR n 1 470 VAL n 1 471 LEU n 1 472 LYS n 1 473 ASN n 1 474 LYS n 1 475 ILE n 1 476 LEU n 1 477 ALA n 1 478 LYS n 1 479 LYS n 1 480 LEU n 1 481 MET n 1 482 ASP n 1 483 LEU n 1 484 TYR n 1 485 LYS n 1 486 THR n 1 487 PRO n 1 488 ASP n 1 489 ASN n 1 490 ILE n 1 491 ASP n 1 492 ILE n 1 493 TRP n 1 494 ILE n 1 495 GLY n 1 496 GLY n 1 497 ASN n 1 498 ALA n 1 499 GLU n 1 500 PRO n 1 501 MET n 1 502 VAL n 1 503 GLU n 1 504 ARG n 1 505 GLY n 1 506 ARG n 1 507 VAL n 1 508 GLY n 1 509 PRO n 1 510 LEU n 1 511 LEU n 1 512 ALA n 1 513 CYS n 1 514 LEU n 1 515 LEU n 1 516 GLY n 1 517 ARG n 1 518 GLN n 1 519 PHE n 1 520 GLN n 1 521 GLN n 1 522 ILE n 1 523 ARG n 1 524 ASP n 1 525 GLY n 1 526 ASP n 1 527 ARG n 1 528 PHE n 1 529 TRP n 1 530 TRP n 1 531 GLU n 1 532 ASN n 1 533 PRO n 1 534 GLY n 1 535 VAL n 1 536 PHE n 1 537 THR n 1 538 GLU n 1 539 LYS n 1 540 GLN n 1 541 ARG n 1 542 ASP n 1 543 SER n 1 544 LEU n 1 545 GLN n 1 546 LYS n 1 547 VAL n 1 548 SER n 1 549 PHE n 1 550 SER n 1 551 ARG n 1 552 LEU n 1 553 ILE n 1 554 CYS n 1 555 ASP n 1 556 ASN n 1 557 THR n 1 558 HIS n 1 559 ILE n 1 560 THR n 1 561 LYS n 1 562 VAL n 1 563 PRO n 1 564 LEU n 1 565 HIS n 1 566 ALA n 1 567 PHE n 1 568 GLN n 1 569 ALA n 1 570 ASN n 1 571 ASN n 1 572 TYR n 1 573 PRO n 1 574 HIS n 1 575 ASP n 1 576 PHE n 1 577 VAL n 1 578 ASP n 1 579 CYS n 1 580 SER n 1 581 THR n 1 582 VAL n 1 583 ASP n 1 584 LYS n 1 585 LEU n 1 586 ASP n 1 587 LEU n 1 588 SER n 1 589 PRO n 1 590 TRP n 1 591 ALA n 1 592 SER n 1 593 ARG n 1 594 GLU n 1 595 ASN n # _entity_src_nat.entity_id 1 _entity_src_nat.pdbx_src_id 1 _entity_src_nat.pdbx_alt_source_flag sample _entity_src_nat.pdbx_beg_seq_num ? _entity_src_nat.pdbx_end_seq_num ? _entity_src_nat.common_name bovine _entity_src_nat.pdbx_organism_scientific 'Bos taurus' _entity_src_nat.pdbx_ncbi_taxonomy_id 9913 _entity_src_nat.genus ? _entity_src_nat.species ? _entity_src_nat.strain ? _entity_src_nat.tissue ? _entity_src_nat.tissue_fraction ? _entity_src_nat.pdbx_secretion ? _entity_src_nat.pdbx_fragment ? _entity_src_nat.pdbx_variant ? _entity_src_nat.pdbx_cell_line ? _entity_src_nat.pdbx_atcc ? _entity_src_nat.pdbx_cellular_location ? _entity_src_nat.pdbx_organ ? _entity_src_nat.pdbx_organelle ? _entity_src_nat.pdbx_cell ? _entity_src_nat.pdbx_plasmid_name ? _entity_src_nat.pdbx_plasmid_details ? _entity_src_nat.details ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code PERL_BOVIN _struct_ref.pdbx_db_accession P80025 _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;SWEVGCGAPVPLVKCDENSPYRTITGDCNNRRSPALGAANRALARWLPAEYEDGLALPFGWTQRKTRNGFRVPLAREVSN KIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELGSNEHSKTQCEEYCIQGDNCFPIMFPKNDPKLKTQGKCMPF FRAGFVCPTPPYQSLAREQINAVTSFLDASLVYGSEPSLASRLRNLSSPLGLMAVNQEAWDHGLAYLPFNNKKPSPCEFI NTTARVPCFLAGDFRASEQILLATAHTLLLREHNRLARELKKLNPHWNGEKLYQEARKILGAFIQIITFRDYLPIVLGSE MQKWIPPYQGYNNSVDPRISNVFTFAFRFGHMEVPSTVSRLDENYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLVRGLL AKKSKLMNQDKMVTSELRNKLFQPTHKIHGFDLAAINLQRCRDHGMPGYNSWRGFCGLSQPKTLKGLQTVLKNKILAKKL MDLYKTPDNIDIWIGGNAEPMVERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTEKQRDSLQKVSFSRLICDNTHIT KVPLHAFQANNYPHDFVDCSTVDKLDLSPWASREN ; _struct_ref.pdbx_align_begin 118 _struct_ref.pdbx_db_isoform ? # _struct_ref_seq.align_id 1 _struct_ref_seq.ref_id 1 _struct_ref_seq.pdbx_PDB_id_code 4PNX _struct_ref_seq.pdbx_strand_id A _struct_ref_seq.seq_align_beg 1 _struct_ref_seq.pdbx_seq_align_beg_ins_code ? _struct_ref_seq.seq_align_end 595 _struct_ref_seq.pdbx_seq_align_end_ins_code ? _struct_ref_seq.pdbx_db_accession P80025 _struct_ref_seq.db_align_beg 118 _struct_ref_seq.pdbx_db_align_beg_ins_code ? _struct_ref_seq.db_align_end 712 _struct_ref_seq.pdbx_db_align_end_ins_code ? _struct_ref_seq.pdbx_auth_seq_align_beg 1 _struct_ref_seq.pdbx_auth_seq_align_end 595 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 BMM non-polymer . BROMOMETHANE ? 'C H3 Br' 94.939 CA non-polymer . 'CALCIUM ION' ? 'Ca 2' 40.078 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HEM non-polymer . 'PROTOPORPHYRIN IX CONTAINING FE' HEME 'C34 H32 Fe N4 O4' 616.487 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 IOD non-polymer . 'IODIDE ION' ? 'I -1' 126.904 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SEP 'L-peptide linking' n PHOSPHOSERINE PHOSPHONOSERINE 'C3 H8 N O6 P' 185.072 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 4PNX _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 2.26 _exptl_crystal.density_percent_sol 45.69 _exptl_crystal.description ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.temp 298 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 6.8 _exptl_crystal_grow.pdbx_details 'pH 6.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K' _exptl_crystal_grow.pdbx_pH_range . # _diffrn.id 1 _diffrn.ambient_temp 77 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type MARRESEARCH _diffrn_detector.pdbx_collection_date 2013-11-26 _diffrn_detector.details mirror # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator graphite _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.97 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'ESRF BEAMLINE BM14' _diffrn_source.pdbx_synchrotron_site ESRF _diffrn_source.pdbx_synchrotron_beamline BM14 _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list 0.97 # _reflns.entry_id 4PNX _reflns.observed_criterion_sigma_I 0.0 _reflns.observed_criterion_sigma_F 0.0 _reflns.d_resolution_low 71.16 _reflns.d_resolution_high 2.41 _reflns.number_obs 23328 _reflns.number_all 23328 _reflns.percent_possible_obs 99.3 _reflns.pdbx_Rmerge_I_obs ? _reflns.pdbx_Rsym_value 0.129 _reflns.pdbx_netI_over_sigmaI 16.5 _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy ? _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # _reflns_shell.d_res_high 2.41 _reflns_shell.d_res_low 2.47 _reflns_shell.percent_possible_all 92.3 _reflns_shell.Rmerge_I_obs ? _reflns_shell.pdbx_Rsym_value 0.379 _reflns_shell.meanI_over_sigI_obs 2.2 _reflns_shell.pdbx_redundancy ? _reflns_shell.percent_possible_obs ? _reflns_shell.number_unique_all ? _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_unique_obs ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_rejects ? _reflns_shell.pdbx_netI_over_sigmaI_obs ? _reflns_shell.number_possible ? _reflns_shell.Rmerge_F_all ? _reflns_shell.Rmerge_F_obs ? _reflns_shell.Rmerge_I_all ? _reflns_shell.meanI_over_sigI_all ? _reflns_shell.pdbx_Rrim_I_all ? _reflns_shell.pdbx_Rpim_I_all ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 # _refine.entry_id 4PNX _refine.ls_number_reflns_obs 21994 _refine.ls_number_reflns_all ? _refine.pdbx_ls_sigma_I 0.0 _refine.pdbx_ls_sigma_F 0.0 _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 71.15 _refine.ls_d_res_high 2.41 _refine.ls_percent_reflns_obs 98.96 _refine.ls_R_factor_obs 0.22302 _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work 0.21869 _refine.ls_R_factor_R_free 0.29910 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 5.1 _refine.ls_number_reflns_R_free 1190 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc 0.929 _refine.correlation_coeff_Fo_to_Fc_free 0.866 _refine.B_iso_mean 38.347 _refine.aniso_B[1][1] -0.40 _refine.aniso_B[2][2] -2.53 _refine.aniso_B[3][3] 1.68 _refine.aniso_B[1][2] 0.00 _refine.aniso_B[1][3] -2.66 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_details MASK _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.40 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details 'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' _refine.pdbx_starting_model 3OGW _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R 0.861 _refine.pdbx_overall_ESU_R_Free 0.352 _refine.overall_SU_ML 0.277 _refine.pdbx_overall_phase_error ? _refine.overall_SU_B 11.748 _refine.overall_SU_R_Cruickshank_DPI ? _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_diffrn_id 1 _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 4774 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 115 _refine_hist.number_atoms_solvent 111 _refine_hist.number_atoms_total 5000 _refine_hist.d_res_high 2.41 _refine_hist.d_res_low 71.15 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_restraint_function _refine_ls_restr.pdbx_refine_id r_bond_refined_d 0.014 ? ? ? ? 'X-RAY DIFFRACTION' r_angle_refined_deg 1.619 ? ? ? ? 'X-RAY DIFFRACTION' r_dihedral_angle_1_deg 7.105 ? ? ? ? 'X-RAY DIFFRACTION' r_dihedral_angle_2_deg 39.054 ? ? ? ? 'X-RAY DIFFRACTION' r_dihedral_angle_3_deg 17.214 ? ? ? ? 'X-RAY DIFFRACTION' r_dihedral_angle_4_deg 14.439 ? ? ? ? 'X-RAY DIFFRACTION' r_chiral_restr 0.109 ? ? ? ? 'X-RAY DIFFRACTION' r_gen_planes_refined 0.009 ? ? ? ? 'X-RAY DIFFRACTION' r_mcbond_it 0.785 ? ? ? ? 'X-RAY DIFFRACTION' r_mcangle_it 1.460 ? ? ? ? 'X-RAY DIFFRACTION' r_scbond_it 2.042 ? ? ? ? 'X-RAY DIFFRACTION' r_scangle_it ? ? ? ? ? 'X-RAY DIFFRACTION' # _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.d_res_high 2.413 _refine_ls_shell.d_res_low 2.476 _refine_ls_shell.number_reflns_R_work 1473 _refine_ls_shell.R_factor_R_work 0.254 _refine_ls_shell.percent_reflns_obs 89.25 _refine_ls_shell.R_factor_R_free 0.343 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.number_reflns_R_free 72 _refine_ls_shell.number_reflns_all ? _refine_ls_shell.R_factor_all ? _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.redundancy_reflns_obs ? # _struct.entry_id 4PNX _struct.title 'Crystal structure of the complex of lactoperoxidase with bromo methane at 2.41 angstrom resolution' _struct.pdbx_descriptor 'Lactoperoxidase (E.C.1.11.1.7)' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 4PNX _struct_keywords.pdbx_keywords OXIDOREDUCTASE _struct_keywords.text Oxidoreductase # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 3 ? D N N 4 ? E N N 4 ? F N N 4 ? G N N 4 ? H N N 5 ? I N N 6 ? J N N 6 ? K N N 6 ? L N N 6 ? M N N 6 ? N N N 6 ? O N N 6 ? P N N 6 ? Q N N 6 ? R N N 6 ? S N N 6 ? T N N 6 ? U N N 6 ? V N N 7 ? # _struct_biol.id 1 _struct_biol.details ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 LEU A 74 ? ILE A 82 ? LEU A 74 ILE A 82 1 ? 9 HELX_P HELX_P2 2 LEU A 98 ? ASP A 112 ? LEU A 98 ASP A 112 1 ? 15 HELX_P HELX_P3 3 GLU A 123 ? CYS A 133 ? GLU A 123 CYS A 133 1 ? 11 HELX_P HELX_P4 4 ASP A 148 ? LYS A 152 ? ASP A 148 LYS A 152 5 ? 5 HELX_P HELX_P5 5 ALA A 189 ? GLY A 194 ? ALA A 189 GLY A 194 1 ? 6 HELX_P HELX_P6 6 GLU A 196 ? LEU A 203 ? GLU A 196 LEU A 203 1 ? 8 HELX_P HELX_P7 7 SER A 235 ? ILE A 240 ? SER A 235 ILE A 240 1 ? 6 HELX_P HELX_P8 8 GLN A 259 ? LYS A 282 ? GLN A 259 LYS A 282 1 ? 24 HELX_P HELX_P9 9 ASN A 288 ? ASP A 311 ? ASN A 288 ASP A 311 1 ? 24 HELX_P HELX_P10 10 TYR A 312 ? GLY A 318 ? TYR A 312 GLY A 318 1 ? 7 HELX_P HELX_P11 11 GLU A 320 ? ILE A 325 ? GLU A 320 ILE A 325 1 ? 6 HELX_P HELX_P12 12 VAL A 342 ? PHE A 347 ? VAL A 342 PHE A 347 1 ? 6 HELX_P HELX_P13 13 ARG A 348 ? VAL A 354 ? ARG A 348 VAL A 354 5 ? 7 HELX_P HELX_P14 14 HIS A 377 ? PHE A 380 ? HIS A 377 PHE A 380 5 ? 4 HELX_P HELX_P15 15 THR A 383 ? LYS A 388 ? THR A 383 LYS A 388 1 ? 6 HELX_P HELX_P16 16 ILE A 392 ? LYS A 402 ? ILE A 392 LYS A 402 1 ? 11 HELX_P HELX_P17 17 THR A 414 ? ASN A 419 ? THR A 414 ASN A 419 1 ? 6 HELX_P HELX_P18 18 ASP A 432 ? HIS A 444 ? ASP A 432 HIS A 444 1 ? 13 HELX_P HELX_P19 19 GLY A 448 ? CYS A 456 ? GLY A 448 CYS A 456 1 ? 9 HELX_P HELX_P20 20 THR A 463 ? LYS A 472 ? THR A 463 LYS A 472 1 ? 10 HELX_P HELX_P21 21 ASN A 473 ? LYS A 485 ? ASN A 473 LYS A 485 1 ? 13 HELX_P HELX_P22 22 ASP A 491 ? GLU A 499 ? ASP A 491 GLU A 499 1 ? 9 HELX_P HELX_P23 23 GLY A 508 ? GLY A 525 ? GLY A 508 GLY A 525 1 ? 18 HELX_P HELX_P24 24 LYS A 539 ? GLN A 545 ? LYS A 539 GLN A 545 1 ? 7 HELX_P HELX_P25 25 SER A 548 ? ASP A 555 ? SER A 548 ASP A 555 1 ? 8 HELX_P HELX_P26 26 SER A 580 ? VAL A 582 ? SER A 580 VAL A 582 5 ? 3 HELX_P HELX_P27 27 LEU A 587 ? ALA A 591 ? LEU A 587 ALA A 591 5 ? 5 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 6 SG ? ? ? 1_555 A CYS 167 SG ? ? A CYS 6 A CYS 167 1_555 ? ? ? ? ? ? ? 2.435 ? disulf2 disulf ? ? A CYS 15 SG ? ? ? 1_555 A CYS 28 SG ? ? A CYS 15 A CYS 28 1_555 ? ? ? ? ? ? ? 2.054 ? disulf3 disulf ? ? A CYS 129 SG ? ? ? 1_555 A CYS 139 SG ? ? A CYS 129 A CYS 139 1_555 ? ? ? ? ? ? ? 2.046 ? disulf4 disulf ? ? A CYS 133 SG ? ? ? 1_555 A CYS 157 SG ? ? A CYS 133 A CYS 157 1_555 ? ? ? ? ? ? ? 2.071 ? disulf5 disulf ? ? A CYS 237 SG ? ? ? 1_555 A CYS 248 SG ? ? A CYS 237 A CYS 248 1_555 ? ? ? ? ? ? ? 2.029 ? disulf6 disulf ? ? A CYS 456 SG ? ? ? 1_555 A CYS 513 SG ? ? A CYS 456 A CYS 513 1_555 ? ? ? ? ? ? ? 2.017 ? disulf7 disulf ? ? A CYS 554 SG ? ? ? 1_555 A CYS 579 SG ? ? A CYS 554 A CYS 579 1_555 ? ? ? ? ? ? ? 2.039 ? covale1 covale ? ? A PRO 197 C ? ? ? 1_555 A SEP 198 N ? ? A PRO 197 A SEP 198 1_555 ? ? ? ? ? ? ? 1.325 ? covale2 covale ? ? A SEP 198 C ? ? ? 1_555 A LEU 199 N ? ? A SEP 198 A LEU 199 1_555 ? ? ? ? ? ? ? 1.327 ? covale3 covale ? ? A ASN 205 ND2 ? ? ? 1_555 E NAG . C1 ? ? A ASN 205 A NAG 604 1_555 ? ? ? ? ? ? ? 1.241 ? metalc1 metalc ? ? A PHE 186 O ? ? ? 1_555 B CA . CA ? ? A PHE 186 A CA 601 1_555 ? ? ? ? ? ? ? 2.181 ? metalc2 metalc ? ? A ASP 110 OD1 ? ? ? 1_555 B CA . CA ? ? A ASP 110 A CA 601 1_555 ? ? ? ? ? ? ? 2.223 ? metalc3 metalc ? ? A THR 184 OG1 ? ? ? 1_555 B CA . CA ? ? A THR 184 A CA 601 1_555 ? ? ? ? ? ? ? 2.311 ? metalc4 metalc ? ? A HIS 351 NE2 ? ? ? 1_555 C HEM . FE ? ? A HIS 351 A HEM 602 1_555 ? ? ? ? ? ? ? 2.344 ? metalc5 metalc ? ? A ASP 110 O ? ? ? 1_555 B CA . CA ? ? A ASP 110 A CA 601 1_555 ? ? ? ? ? ? ? 2.361 ? metalc6 metalc ? ? A THR 184 O ? ? ? 1_555 B CA . CA ? ? A THR 184 A CA 601 1_555 ? ? ? ? ? ? ? 2.434 ? metalc7 metalc ? ? A ASP 188 OD1 ? ? ? 1_555 B CA . CA ? ? A ASP 188 A CA 601 1_555 ? ? ? ? ? ? ? 2.458 ? metalc8 metalc ? ? A SER 190 OG ? ? ? 1_555 B CA . CA ? ? A SER 190 A CA 601 1_555 ? ? ? ? ? ? ? 2.683 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? metalc ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 LYS 233 A . ? LYS 233 A PRO 234 A ? PRO 234 A 1 -4.07 2 TYR 572 A . ? TYR 572 A PRO 573 A ? PRO 573 A 1 -2.26 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 2 ? B ? 2 ? C ? 2 ? D ? 2 ? E ? 2 ? F ? 2 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? anti-parallel B 1 2 ? anti-parallel C 1 2 ? anti-parallel D 1 2 ? anti-parallel E 1 2 ? anti-parallel F 1 2 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 ARG A 41 ? ALA A 42 ? ARG A 41 ALA A 42 A 2 ILE A 180 ? ASN A 181 ? ILE A 180 ASN A 181 B 1 LEU A 92 ? SER A 97 ? LEU A 92 SER A 97 B 2 LYS A 403 ? LYS A 405 ? LYS A 403 LYS A 405 C 1 ILE A 142 ? MET A 143 ? ILE A 142 MET A 143 C 2 CYS A 157 ? MET A 158 ? CYS A 157 MET A 158 D 1 THR A 357 ? SER A 359 ? THR A 357 SER A 359 D 2 GLU A 373 ? PRO A 375 ? GLU A 373 PRO A 375 E 1 LEU A 421 ? PHE A 422 ? LEU A 421 PHE A 422 E 2 HIS A 429 ? PHE A 431 ? HIS A 429 PHE A 431 F 1 LYS A 561 ? PRO A 563 ? LYS A 561 PRO A 563 F 2 PHE A 576 ? ASP A 578 ? PHE A 576 ASP A 578 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 N ARG A 41 ? N ARG A 41 O ASN A 181 ? O ASN A 181 B 1 2 N ASP A 93 ? N ASP A 93 O SER A 404 ? O SER A 404 C 1 2 N ILE A 142 ? N ILE A 142 O MET A 158 ? O MET A 158 D 1 2 N VAL A 358 ? N VAL A 358 O LEU A 374 ? O LEU A 374 E 1 2 N LEU A 421 ? N LEU A 421 O PHE A 431 ? O PHE A 431 F 1 2 N VAL A 562 ? N VAL A 562 O VAL A 577 ? O VAL A 577 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE CA A 601' AC2 Software ? ? ? ? 20 'BINDING SITE FOR RESIDUE HEM A 602' AC3 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE NAG A 603' AC4 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE NAG A 605' AC5 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE NAG A 606' AC6 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE BMM A 607' AC7 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE IOD A 608' AC8 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE IOD A 609' AC9 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE IOD A 611' BC1 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE IOD A 612' BC2 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE IOD A 613' BC3 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE IOD A 614' BC4 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE IOD A 615' BC5 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE IOD A 616' BC6 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE IOD A 617' BC7 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE IOD A 618' BC8 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE IOD A 619' BC9 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE IOD A 620' CC1 Software ? ? ? ? 5 'BINDING SITE FOR MONO-SACCHARIDE NAG A 604 BOUND TO ASN A 205' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 5 ASP A 110 ? ASP A 110 . ? 1_555 ? 2 AC1 5 THR A 184 ? THR A 184 . ? 1_555 ? 3 AC1 5 PHE A 186 ? PHE A 186 . ? 1_555 ? 4 AC1 5 ASP A 188 ? ASP A 188 . ? 1_555 ? 5 AC1 5 SER A 190 ? SER A 190 . ? 1_555 ? 6 AC2 20 MET A 101 ? MET A 101 . ? 1_555 ? 7 AC2 20 GLY A 104 ? GLY A 104 . ? 1_555 ? 8 AC2 20 GLN A 105 ? GLN A 105 . ? 1_555 ? 9 AC2 20 ASP A 108 ? ASP A 108 . ? 1_555 ? 10 AC2 20 ASP A 112 ? ASP A 112 . ? 1_555 ? 11 AC2 20 PHE A 113 ? PHE A 113 . ? 1_555 ? 12 AC2 20 ALA A 114 ? ALA A 114 . ? 1_555 ? 13 AC2 20 ARG A 255 ? ARG A 255 . ? 1_555 ? 14 AC2 20 GLU A 258 ? GLU A 258 . ? 1_555 ? 15 AC2 20 THR A 344 ? THR A 344 . ? 1_555 ? 16 AC2 20 PHE A 347 ? PHE A 347 . ? 1_555 ? 17 AC2 20 ARG A 348 ? ARG A 348 . ? 1_555 ? 18 AC2 20 GLY A 350 ? GLY A 350 . ? 1_555 ? 19 AC2 20 HIS A 351 ? HIS A 351 . ? 1_555 ? 20 AC2 20 PHE A 380 ? PHE A 380 . ? 1_555 ? 21 AC2 20 LEU A 417 ? LEU A 417 . ? 1_555 ? 22 AC2 20 GLN A 423 ? GLN A 423 . ? 1_555 ? 23 AC2 20 ILE A 436 ? ILE A 436 . ? 1_555 ? 24 AC2 20 ARG A 440 ? ARG A 440 . ? 1_555 ? 25 AC2 20 BMM H . ? BMM A 607 . ? 1_555 ? 26 AC3 2 ASN A 95 ? ASN A 95 . ? 1_555 ? 27 AC3 2 ILE A 315 ? ILE A 315 . ? 1_555 ? 28 AC4 4 ASN A 241 ? ASN A 241 . ? 1_555 ? 29 AC4 4 ALA A 244 ? ALA A 244 . ? 1_555 ? 30 AC4 4 TRP A 384 ? TRP A 384 . ? 1_555 ? 31 AC4 4 HOH V . ? HOH A 811 . ? 1_555 ? 32 AC5 2 ASN A 332 ? ASN A 332 . ? 1_555 ? 33 AC5 2 SER A 334 ? SER A 334 . ? 1_555 ? 34 AC6 4 GLN A 105 ? GLN A 105 . ? 1_555 ? 35 AC6 4 HIS A 109 ? HIS A 109 . ? 1_555 ? 36 AC6 4 GLU A 258 ? GLU A 258 . ? 1_555 ? 37 AC6 4 HEM C . ? HEM A 602 . ? 1_555 ? 38 AC7 3 TRP A 46 ? TRP A 46 . ? 1_555 ? 39 AC7 3 VAL A 342 ? VAL A 342 . ? 1_555 ? 40 AC7 3 TRP A 452 ? TRP A 452 . ? 1_555 ? 41 AC8 2 ARG A 397 ? ARG A 397 . ? 1_555 ? 42 AC8 2 THR A 560 ? THR A 560 . ? 1_555 ? 43 AC9 2 ASN A 216 ? ASN A 216 . ? 1_555 ? 44 AC9 2 PHE A 229 ? PHE A 229 . ? 1_555 ? 45 BC1 2 ASN A 95 ? ASN A 95 . ? 1_555 ? 46 BC1 2 ARG A 96 ? ARG A 96 . ? 1_555 ? 47 BC2 2 LYS A 462 ? LYS A 462 . ? 1_455 ? 48 BC2 2 THR A 463 ? THR A 463 . ? 1_455 ? 49 BC3 2 ASN A 80 ? ASN A 80 . ? 1_555 ? 50 BC3 2 PRO A 145 ? PRO A 145 . ? 1_555 ? 51 BC4 1 THR A 425 ? THR A 425 . ? 1_555 ? 52 BC5 1 SER A 359 ? SER A 359 . ? 1_555 ? 53 BC6 1 HIS A 377 ? HIS A 377 . ? 1_555 ? 54 BC7 1 PRO A 375 ? PRO A 375 . ? 1_555 ? 55 BC8 1 PRO A 149 ? PRO A 149 . ? 1_555 ? 56 BC9 1 ILE A 24 ? ILE A 24 . ? 1_555 ? 57 CC1 5 ASN A 205 ? ASN A 205 . ? 1_555 ? 58 CC1 5 LEU A 212 ? LEU A 212 . ? 1_555 ? 59 CC1 5 VAL A 215 ? VAL A 215 . ? 1_555 ? 60 CC1 5 GLN A 217 ? GLN A 217 . ? 1_555 ? 61 CC1 5 HOH V . ? HOH A 725 . ? 1_555 ? # _database_PDB_matrix.entry_id 4PNX _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 4PNX _atom_sites.fract_transf_matrix[1][1] 0.018607 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.004468 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.012441 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.014054 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol BR C CA FE I N O P S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . SER A 1 1 ? -20.222 -32.060 33.055 1.00 101.90 ? 1 SER A N 1 ATOM 2 C CA . SER A 1 1 ? -21.540 -31.759 32.419 1.00 101.95 ? 1 SER A CA 1 ATOM 3 C C . SER A 1 1 ? -22.554 -31.108 33.380 1.00 101.91 ? 1 SER A C 1 ATOM 4 O O . SER A 1 1 ? -23.070 -31.766 34.295 1.00 101.82 ? 1 SER A O 1 ATOM 5 C CB . SER A 1 1 ? -22.128 -33.021 31.766 1.00 101.97 ? 1 SER A CB 1 ATOM 6 O OG . SER A 1 1 ? -22.026 -34.152 32.615 1.00 101.94 ? 1 SER A OG 1 ATOM 7 N N . TRP A 1 2 ? -22.814 -29.814 33.163 1.00 101.77 ? 2 TRP A N 1 ATOM 8 C CA . TRP A 1 2 ? -23.869 -29.069 33.872 1.00 101.54 ? 2 TRP A CA 1 ATOM 9 C C . TRP A 1 2 ? -24.635 -29.092 32.537 1.00 100.93 ? 2 TRP A C 1 ATOM 10 O O . TRP A 1 2 ? -24.124 -29.600 31.533 1.00 100.81 ? 2 TRP A O 1 ATOM 11 C CB . TRP A 1 2 ? -23.644 -27.546 33.786 1.00 101.91 ? 2 TRP A CB 1 ATOM 12 C CG . TRP A 1 2 ? -22.208 -27.084 33.992 1.00 103.22 ? 2 TRP A CG 1 ATOM 13 C CD1 . TRP A 1 2 ? -21.391 -27.372 35.057 1.00 103.80 ? 2 TRP A CD1 1 ATOM 14 C CD2 . TRP A 1 2 ? -21.438 -26.236 33.117 1.00 104.26 ? 2 TRP A CD2 1 ATOM 15 N NE1 . TRP A 1 2 ? -20.163 -26.764 34.893 1.00 104.21 ? 2 TRP A NE1 1 ATOM 16 C CE2 . TRP A 1 2 ? -20.164 -26.063 33.715 1.00 104.35 ? 2 TRP A CE2 1 ATOM 17 C CE3 . TRP A 1 2 ? -21.699 -25.610 31.886 1.00 104.33 ? 2 TRP A CE3 1 ATOM 18 C CZ2 . TRP A 1 2 ? -19.154 -25.290 33.123 1.00 104.49 ? 2 TRP A CZ2 1 ATOM 19 C CZ3 . TRP A 1 2 ? -20.693 -24.842 31.299 1.00 104.29 ? 2 TRP A CZ3 1 ATOM 20 C CH2 . TRP A 1 2 ? -19.437 -24.690 31.920 1.00 104.61 ? 2 TRP A CH2 1 ATOM 21 N N . GLU A 1 3 ? -25.850 -28.544 32.527 1.00 100.04 ? 3 GLU A N 1 ATOM 22 C CA . GLU A 1 3 ? -27.058 -28.866 31.762 1.00 99.15 ? 3 GLU A CA 1 ATOM 23 C C . GLU A 1 3 ? -26.982 -28.318 30.330 1.00 98.47 ? 3 GLU A C 1 ATOM 24 O O . GLU A 1 3 ? -25.906 -27.924 29.862 1.00 98.34 ? 3 GLU A O 1 ATOM 25 C CB . GLU A 1 3 ? -28.334 -28.397 32.489 1.00 99.24 ? 3 GLU A CB 1 ATOM 26 C CG . GLU A 1 3 ? -28.394 -26.900 32.825 1.00 99.52 ? 3 GLU A CG 1 ATOM 27 C CD . GLU A 1 3 ? -29.782 -26.427 33.267 1.00 99.70 ? 3 GLU A CD 1 ATOM 28 O OE1 . GLU A 1 3 ? -30.788 -27.130 33.007 1.00 99.43 ? 3 GLU A OE1 1 ATOM 29 O OE2 . GLU A 1 3 ? -29.863 -25.337 33.875 1.00 99.22 ? 3 GLU A OE2 1 ATOM 30 N N . VAL A 1 4 ? -28.123 -28.327 29.639 1.00 97.52 ? 4 VAL A N 1 ATOM 31 C CA . VAL A 1 4 ? -28.266 -27.697 28.324 1.00 96.33 ? 4 VAL A CA 1 ATOM 32 C C . VAL A 1 4 ? -29.076 -26.407 28.513 1.00 95.32 ? 4 VAL A C 1 ATOM 33 O O . VAL A 1 4 ? -30.308 -26.401 28.423 1.00 95.20 ? 4 VAL A O 1 ATOM 34 C CB . VAL A 1 4 ? -28.909 -28.667 27.271 1.00 96.50 ? 4 VAL A CB 1 ATOM 35 C CG1 . VAL A 1 4 ? -29.114 -27.978 25.919 1.00 96.57 ? 4 VAL A CG1 1 ATOM 36 C CG2 . VAL A 1 4 ? -28.050 -29.917 27.095 1.00 96.49 ? 4 VAL A CG2 1 ATOM 37 N N . GLY A 1 5 ? -28.360 -25.329 28.823 1.00 94.13 ? 5 GLY A N 1 ATOM 38 C CA . GLY A 1 5 ? -28.951 -24.007 29.020 1.00 92.82 ? 5 GLY A CA 1 ATOM 39 C C . GLY A 1 5 ? -29.625 -23.960 30.386 1.00 91.70 ? 5 GLY A C 1 ATOM 40 O O . GLY A 1 5 ? -29.997 -24.999 30.942 1.00 91.65 ? 5 GLY A O 1 ATOM 41 N N . CYS A 1 6 ? -29.514 -22.788 30.988 1.00 90.40 ? 6 CYS A N 1 ATOM 42 C CA . CYS A 1 6 ? -30.101 -22.487 32.266 1.00 88.99 ? 6 CYS A CA 1 ATOM 43 C C . CYS A 1 6 ? -30.944 -21.343 31.808 1.00 89.31 ? 6 CYS A C 1 ATOM 44 O O . CYS A 1 6 ? -30.442 -20.384 31.222 1.00 89.34 ? 6 CYS A O 1 ATOM 45 C CB . CYS A 1 6 ? -29.040 -22.012 33.254 1.00 88.13 ? 6 CYS A CB 1 ATOM 46 S SG . CYS A 1 6 ? -29.678 -21.609 34.897 1.00 84.01 ? 6 CYS A SG 1 ATOM 47 N N . GLY A 1 7 ? -32.234 -21.443 32.045 1.00 89.38 ? 7 GLY A N 1 ATOM 48 C CA . GLY A 1 7 ? -33.145 -20.445 31.482 1.00 89.37 ? 7 GLY A CA 1 ATOM 49 C C . GLY A 1 7 ? -34.186 -20.492 32.583 1.00 89.43 ? 7 GLY A C 1 ATOM 50 O O . GLY A 1 7 ? -34.703 -21.562 32.914 1.00 89.63 ? 7 GLY A O 1 ATOM 51 N N . ALA A 1 8 ? -34.496 -19.329 33.150 1.00 89.36 ? 8 ALA A N 1 ATOM 52 C CA . ALA A 1 8 ? -35.754 -18.845 33.723 1.00 89.25 ? 8 ALA A CA 1 ATOM 53 C C . ALA A 1 8 ? -36.285 -17.628 32.925 1.00 89.18 ? 8 ALA A C 1 ATOM 54 O O . ALA A 1 8 ? -37.507 -17.479 32.758 1.00 89.10 ? 8 ALA A O 1 ATOM 55 C CB . ALA A 1 8 ? -35.601 -18.527 35.213 1.00 89.25 ? 8 ALA A CB 1 ATOM 56 N N . PRO A 1 9 ? -35.373 -16.744 32.449 1.00 88.89 ? 9 PRO A N 1 ATOM 57 C CA . PRO A 1 9 ? -35.749 -15.849 31.347 1.00 88.65 ? 9 PRO A CA 1 ATOM 58 C C . PRO A 1 9 ? -35.620 -16.492 29.943 1.00 88.26 ? 9 PRO A C 1 ATOM 59 O O . PRO A 1 9 ? -34.770 -16.082 29.139 1.00 88.11 ? 9 PRO A O 1 ATOM 60 C CB . PRO A 1 9 ? -34.785 -14.660 31.514 1.00 88.59 ? 9 PRO A CB 1 ATOM 61 C CG . PRO A 1 9 ? -34.309 -14.742 32.922 1.00 88.70 ? 9 PRO A CG 1 ATOM 62 C CD . PRO A 1 9 ? -34.218 -16.206 33.190 1.00 88.81 ? 9 PRO A CD 1 ATOM 63 N N . VAL A 1 10 ? -36.536 -17.384 29.564 1.00 87.73 ? 10 VAL A N 1 ATOM 64 C CA . VAL A 1 10 ? -36.608 -17.973 28.194 1.00 87.23 ? 10 VAL A CA 1 ATOM 65 C C . VAL A 1 10 ? -38.083 -17.777 27.827 1.00 86.87 ? 10 VAL A C 1 ATOM 66 O O . VAL A 1 10 ? -38.844 -18.719 27.614 1.00 86.85 ? 10 VAL A O 1 ATOM 67 C CB . VAL A 1 10 ? -36.213 -19.497 28.179 1.00 87.20 ? 10 VAL A CB 1 ATOM 68 C CG1 . VAL A 1 10 ? -37.124 -20.314 29.058 1.00 86.65 ? 10 VAL A CG1 1 ATOM 69 C CG2 . VAL A 1 10 ? -36.207 -20.055 26.780 1.00 86.92 ? 10 VAL A CG2 1 ATOM 70 N N . PRO A 1 11 ? -38.418 -16.499 27.683 1.00 86.36 ? 11 PRO A N 1 ATOM 71 C CA . PRO A 1 11 ? -39.741 -15.877 27.847 1.00 85.69 ? 11 PRO A CA 1 ATOM 72 C C . PRO A 1 11 ? -40.562 -15.969 26.565 1.00 84.95 ? 11 PRO A C 1 ATOM 73 O O . PRO A 1 11 ? -40.723 -14.967 25.847 1.00 84.74 ? 11 PRO A O 1 ATOM 74 C CB . PRO A 1 11 ? -39.493 -14.409 28.217 1.00 85.83 ? 11 PRO A CB 1 ATOM 75 C CG . PRO A 1 11 ? -38.072 -14.109 27.751 1.00 86.14 ? 11 PRO A CG 1 ATOM 76 C CD . PRO A 1 11 ? -37.428 -15.398 27.305 1.00 86.43 ? 11 PRO A CD 1 ATOM 77 N N . LEU A 1 12 ? -40.973 -17.190 26.296 1.00 84.02 ? 12 LEU A N 1 ATOM 78 C CA . LEU A 1 12 ? -41.747 -17.467 25.118 1.00 82.99 ? 12 LEU A CA 1 ATOM 79 C C . LEU A 1 12 ? -40.782 -17.662 23.954 1.00 82.04 ? 12 LEU A C 1 ATOM 80 O O . LEU A 1 12 ? -40.284 -16.674 23.431 1.00 82.05 ? 12 LEU A O 1 ATOM 81 C CB . LEU A 1 12 ? -42.775 -16.327 24.822 1.00 83.00 ? 12 LEU A CB 1 ATOM 82 C CG . LEU A 1 12 ? -44.149 -16.164 25.539 1.00 82.40 ? 12 LEU A CG 1 ATOM 83 C CD1 . LEU A 1 12 ? -44.734 -14.795 25.411 1.00 81.50 ? 12 LEU A CD1 1 ATOM 84 C CD2 . LEU A 1 12 ? -45.183 -17.162 25.155 1.00 81.17 ? 12 LEU A CD2 1 ATOM 85 N N . VAL A 1 13 ? -40.518 -18.920 23.580 1.00 80.61 ? 13 VAL A N 1 ATOM 86 C CA . VAL A 1 13 ? -39.777 -19.254 22.360 1.00 79.10 ? 13 VAL A CA 1 ATOM 87 C C . VAL A 1 13 ? -40.656 -20.167 21.494 1.00 77.85 ? 13 VAL A C 1 ATOM 88 O O . VAL A 1 13 ? -40.599 -21.401 21.592 1.00 77.65 ? 13 VAL A O 1 ATOM 89 C CB . VAL A 1 13 ? -38.386 -19.906 22.626 1.00 79.28 ? 13 VAL A CB 1 ATOM 90 C CG1 . VAL A 1 13 ? -37.578 -20.026 21.315 1.00 79.11 ? 13 VAL A CG1 1 ATOM 91 C CG2 . VAL A 1 13 ? -37.605 -19.108 23.662 1.00 79.31 ? 13 VAL A CG2 1 ATOM 92 N N . LYS A 1 14 ? -41.507 -19.540 20.688 1.00 76.15 ? 14 LYS A N 1 ATOM 93 C CA . LYS A 1 14 ? -42.232 -20.243 19.637 1.00 74.52 ? 14 LYS A CA 1 ATOM 94 C C . LYS A 1 14 ? -41.638 -19.786 18.312 1.00 72.86 ? 14 LYS A C 1 ATOM 95 O O . LYS A 1 14 ? -41.494 -18.577 18.055 1.00 72.61 ? 14 LYS A O 1 ATOM 96 C CB . LYS A 1 14 ? -43.748 -20.009 19.706 1.00 74.66 ? 14 LYS A CB 1 ATOM 97 C CG . LYS A 1 14 ? -44.179 -18.549 19.807 1.00 75.81 ? 14 LYS A CG 1 ATOM 98 C CD . LYS A 1 14 ? -45.567 -18.327 19.198 1.00 77.04 ? 14 LYS A CD 1 ATOM 99 C CE . LYS A 1 14 ? -45.967 -16.857 19.244 1.00 76.85 ? 14 LYS A CE 1 ATOM 100 N NZ . LYS A 1 14 ? -47.404 -16.683 18.905 1.00 76.85 ? 14 LYS A NZ 1 ATOM 101 N N . CYS A 1 15 ? -41.258 -20.758 17.489 1.00 70.75 ? 15 CYS A N 1 ATOM 102 C CA . CYS A 1 15 ? -40.442 -20.441 16.334 1.00 68.44 ? 15 CYS A CA 1 ATOM 103 C C . CYS A 1 15 ? -41.214 -20.458 15.048 1.00 68.50 ? 15 CYS A C 1 ATOM 104 O O . CYS A 1 15 ? -41.878 -21.444 14.715 1.00 68.39 ? 15 CYS A O 1 ATOM 105 C CB . CYS A 1 15 ? -39.213 -21.358 16.233 1.00 67.53 ? 15 CYS A CB 1 ATOM 106 S SG . CYS A 1 15 ? -37.856 -20.654 15.225 1.00 61.47 ? 15 CYS A SG 1 ATOM 107 N N . ASP A 1 16 ? -41.139 -19.340 14.340 1.00 68.42 ? 16 ASP A N 1 ATOM 108 C CA . ASP A 1 16 ? -41.460 -19.348 12.934 1.00 68.27 ? 16 ASP A CA 1 ATOM 109 C C . ASP A 1 16 ? -40.142 -19.373 12.161 1.00 68.25 ? 16 ASP A C 1 ATOM 110 O O . ASP A 1 16 ? -39.282 -18.470 12.273 1.00 68.13 ? 16 ASP A O 1 ATOM 111 C CB . ASP A 1 16 ? -42.352 -18.181 12.503 1.00 68.09 ? 16 ASP A CB 1 ATOM 112 C CG . ASP A 1 16 ? -42.659 -18.217 11.012 1.00 68.80 ? 16 ASP A CG 1 ATOM 113 O OD1 . ASP A 1 16 ? -43.059 -17.177 10.445 1.00 68.79 ? 16 ASP A OD1 1 ATOM 114 O OD2 . ASP A 1 16 ? -42.480 -19.295 10.398 1.00 69.25 ? 16 ASP A OD2 1 ATOM 115 N N . GLU A 1 17 ? -39.990 -20.448 11.397 1.00 67.79 ? 17 GLU A N 1 ATOM 116 C CA . GLU A 1 17 ? -38.858 -20.613 10.516 1.00 67.18 ? 17 GLU A CA 1 ATOM 117 C C . GLU A 1 17 ? -39.167 -19.748 9.314 1.00 66.19 ? 17 GLU A C 1 ATOM 118 O O . GLU A 1 17 ? -38.312 -18.995 8.823 1.00 66.21 ? 17 GLU A O 1 ATOM 119 C CB . GLU A 1 17 ? -38.747 -22.073 10.060 1.00 67.56 ? 17 GLU A CB 1 ATOM 120 C CG . GLU A 1 17 ? -39.568 -23.081 10.866 1.00 69.42 ? 17 GLU A CG 1 ATOM 121 C CD . GLU A 1 17 ? -38.739 -23.859 11.866 1.00 71.27 ? 17 GLU A CD 1 ATOM 122 O OE1 . GLU A 1 17 ? -38.644 -25.096 11.697 1.00 71.98 ? 17 GLU A OE1 1 ATOM 123 O OE2 . GLU A 1 17 ? -38.189 -23.241 12.811 1.00 71.93 ? 17 GLU A OE2 1 ATOM 124 N N . ASN A 1 18 ? -40.409 -19.883 8.849 1.00 64.57 ? 18 ASN A N 1 ATOM 125 C CA . ASN A 1 18 ? -40.901 -19.252 7.629 1.00 62.93 ? 18 ASN A CA 1 ATOM 126 C C . ASN A 1 18 ? -41.001 -17.736 7.704 1.00 61.42 ? 18 ASN A C 1 ATOM 127 O O . ASN A 1 18 ? -42.089 -17.169 7.812 1.00 61.47 ? 18 ASN A O 1 ATOM 128 C CB . ASN A 1 18 ? -42.257 -19.844 7.235 1.00 63.02 ? 18 ASN A CB 1 ATOM 129 C CG . ASN A 1 18 ? -42.237 -21.359 7.176 1.00 64.42 ? 18 ASN A CG 1 ATOM 130 O OD1 . ASN A 1 18 ? -41.598 -21.950 6.306 1.00 65.31 ? 18 ASN A OD1 1 ATOM 131 N ND2 . ASN A 1 18 ? -42.939 -21.996 8.106 1.00 65.22 ? 18 ASN A ND2 1 ATOM 132 N N . SER A 1 19 ? -39.845 -17.094 7.637 1.00 58.66 ? 19 SER A N 1 ATOM 133 C CA . SER A 1 19 ? -39.735 -15.637 7.566 1.00 55.95 ? 19 SER A CA 1 ATOM 134 C C . SER A 1 19 ? -38.698 -15.196 6.524 1.00 53.80 ? 19 SER A C 1 ATOM 135 O O . SER A 1 19 ? -37.641 -15.826 6.381 1.00 53.37 ? 19 SER A O 1 ATOM 136 C CB . SER A 1 19 ? -39.388 -15.038 8.936 1.00 56.00 ? 19 SER A CB 1 ATOM 137 O OG . SER A 1 19 ? -40.523 -14.466 9.568 1.00 55.73 ? 19 SER A OG 1 ATOM 138 N N . PRO A 1 20 ? -39.018 -14.130 5.770 1.00 51.53 ? 20 PRO A N 1 ATOM 139 C CA . PRO A 1 20 ? -38.011 -13.458 4.934 1.00 49.58 ? 20 PRO A CA 1 ATOM 140 C C . PRO A 1 20 ? -37.229 -12.409 5.716 1.00 47.59 ? 20 PRO A C 1 ATOM 141 O O . PRO A 1 20 ? -36.331 -11.767 5.146 1.00 47.86 ? 20 PRO A O 1 ATOM 142 C CB . PRO A 1 20 ? -38.838 -12.770 3.848 1.00 49.70 ? 20 PRO A CB 1 ATOM 143 C CG . PRO A 1 20 ? -40.243 -12.687 4.393 1.00 50.71 ? 20 PRO A CG 1 ATOM 144 C CD . PRO A 1 20 ? -40.391 -13.639 5.536 1.00 50.76 ? 20 PRO A CD 1 ATOM 145 N N . TYR A 1 21 ? -37.563 -12.240 6.999 1.00 44.78 ? 21 TYR A N 1 ATOM 146 C CA . TYR A 1 21 ? -36.952 -11.200 7.847 1.00 42.43 ? 21 TYR A CA 1 ATOM 147 C C . TYR A 1 21 ? -36.445 -11.725 9.224 1.00 41.88 ? 21 TYR A C 1 ATOM 148 O O . TYR A 1 21 ? -36.913 -12.765 9.745 1.00 41.74 ? 21 TYR A O 1 ATOM 149 C CB . TYR A 1 21 ? -37.897 -9.984 8.003 1.00 41.79 ? 21 TYR A CB 1 ATOM 150 C CG . TYR A 1 21 ? -38.496 -9.492 6.686 1.00 39.23 ? 21 TYR A CG 1 ATOM 151 C CD1 . TYR A 1 21 ? -39.884 -9.550 6.439 1.00 35.96 ? 21 TYR A CD1 1 ATOM 152 C CD2 . TYR A 1 21 ? -37.672 -8.998 5.678 1.00 37.78 ? 21 TYR A CD2 1 ATOM 153 C CE1 . TYR A 1 21 ? -40.421 -9.115 5.217 1.00 34.09 ? 21 TYR A CE1 1 ATOM 154 C CE2 . TYR A 1 21 ? -38.183 -8.579 4.461 1.00 35.80 ? 21 TYR A CE2 1 ATOM 155 C CZ . TYR A 1 21 ? -39.550 -8.640 4.231 1.00 36.43 ? 21 TYR A CZ 1 ATOM 156 O OH . TYR A 1 21 ? -39.997 -8.195 3.007 1.00 34.87 ? 21 TYR A OH 1 ATOM 157 N N . ARG A 1 22 ? -35.468 -11.023 9.803 1.00 40.54 ? 22 ARG A N 1 ATOM 158 C CA . ARG A 1 22 ? -34.936 -11.410 11.107 1.00 38.90 ? 22 ARG A CA 1 ATOM 159 C C . ARG A 1 22 ? -36.074 -11.197 12.075 1.00 38.66 ? 22 ARG A C 1 ATOM 160 O O . ARG A 1 22 ? -36.947 -10.381 11.798 1.00 38.47 ? 22 ARG A O 1 ATOM 161 C CB . ARG A 1 22 ? -33.766 -10.503 11.525 1.00 38.84 ? 22 ARG A CB 1 ATOM 162 C CG . ARG A 1 22 ? -32.590 -10.366 10.535 1.00 35.93 ? 22 ARG A CG 1 ATOM 163 C CD . ARG A 1 22 ? -31.405 -9.590 11.162 1.00 33.56 ? 22 ARG A CD 1 ATOM 164 N NE . ARG A 1 22 ? -30.323 -9.374 10.191 1.00 31.37 ? 22 ARG A NE 1 ATOM 165 C CZ . ARG A 1 22 ? -29.247 -10.141 10.083 1.00 28.95 ? 22 ARG A CZ 1 ATOM 166 N NH1 . ARG A 1 22 ? -29.068 -11.159 10.916 1.00 27.85 ? 22 ARG A NH1 1 ATOM 167 N NH2 . ARG A 1 22 ? -28.348 -9.895 9.142 1.00 29.67 ? 22 ARG A NH2 1 ATOM 168 N N . THR A 1 23 ? -36.074 -11.902 13.204 1.00 38.08 ? 23 THR A N 1 ATOM 169 C CA . THR A 1 23 ? -36.831 -11.413 14.352 1.00 37.78 ? 23 THR A CA 1 ATOM 170 C C . THR A 1 23 ? -36.191 -10.106 14.878 1.00 37.34 ? 23 THR A C 1 ATOM 171 O O . THR A 1 23 ? -35.154 -9.652 14.400 1.00 37.51 ? 23 THR A O 1 ATOM 172 C CB . THR A 1 23 ? -36.948 -12.456 15.510 1.00 37.71 ? 23 THR A CB 1 ATOM 173 O OG1 . THR A 1 23 ? -35.648 -12.904 15.885 1.00 39.76 ? 23 THR A OG1 1 ATOM 174 C CG2 . THR A 1 23 ? -37.776 -13.648 15.097 1.00 37.16 ? 23 THR A CG2 1 ATOM 175 N N . ILE A 1 24 ? -36.823 -9.484 15.855 1.00 36.51 ? 24 ILE A N 1 ATOM 176 C CA . ILE A 1 24 ? -36.187 -8.388 16.543 1.00 35.40 ? 24 ILE A CA 1 ATOM 177 C C . ILE A 1 24 ? -35.208 -8.948 17.583 1.00 35.05 ? 24 ILE A C 1 ATOM 178 O O . ILE A 1 24 ? -34.093 -8.442 17.724 1.00 34.42 ? 24 ILE A O 1 ATOM 179 C CB . ILE A 1 24 ? -37.240 -7.439 17.167 1.00 34.94 ? 24 ILE A CB 1 ATOM 180 C CG1 . ILE A 1 24 ? -37.749 -6.459 16.104 1.00 34.61 ? 24 ILE A CG1 1 ATOM 181 C CG2 . ILE A 1 24 ? -36.694 -6.716 18.362 1.00 33.09 ? 24 ILE A CG2 1 ATOM 182 C CD1 . ILE A 1 24 ? -36.697 -5.418 15.597 1.00 35.66 ? 24 ILE A CD1 1 ATOM 183 N N . THR A 1 25 ? -35.621 -10.013 18.273 1.00 34.27 ? 25 THR A N 1 ATOM 184 C CA . THR A 1 25 ? -34.844 -10.544 19.392 1.00 33.69 ? 25 THR A CA 1 ATOM 185 C C . THR A 1 25 ? -33.610 -11.329 18.959 1.00 33.48 ? 25 THR A C 1 ATOM 186 O O . THR A 1 25 ? -32.763 -11.631 19.801 1.00 32.99 ? 25 THR A O 1 ATOM 187 C CB . THR A 1 25 ? -35.670 -11.503 20.276 1.00 33.57 ? 25 THR A CB 1 ATOM 188 O OG1 . THR A 1 25 ? -36.098 -12.613 19.483 1.00 32.85 ? 25 THR A OG1 1 ATOM 189 C CG2 . THR A 1 25 ? -36.865 -10.808 20.889 1.00 32.61 ? 25 THR A CG2 1 ATOM 190 N N . GLY A 1 26 ? -33.540 -11.684 17.673 1.00 33.02 ? 26 GLY A N 1 ATOM 191 C CA . GLY A 1 26 ? -32.495 -12.568 17.156 1.00 33.42 ? 26 GLY A CA 1 ATOM 192 C C . GLY A 1 26 ? -32.845 -14.049 17.175 1.00 33.80 ? 26 GLY A C 1 ATOM 193 O O . GLY A 1 26 ? -32.171 -14.857 16.539 1.00 32.38 ? 26 GLY A O 1 ATOM 194 N N . ASP A 1 27 ? -33.907 -14.403 17.901 1.00 34.75 ? 27 ASP A N 1 ATOM 195 C CA . ASP A 1 27 ? -34.433 -15.768 17.890 1.00 36.26 ? 27 ASP A CA 1 ATOM 196 C C . ASP A 1 27 ? -34.884 -16.335 16.528 1.00 36.41 ? 27 ASP A C 1 ATOM 197 O O . ASP A 1 27 ? -35.515 -15.633 15.735 1.00 36.04 ? 27 ASP A O 1 ATOM 198 C CB . ASP A 1 27 ? -35.733 -15.849 18.682 1.00 36.34 ? 27 ASP A CB 1 ATOM 199 C CG . ASP A 1 27 ? -35.511 -15.701 20.153 1.00 38.56 ? 27 ASP A CG 1 ATOM 200 O OD1 . ASP A 1 27 ? -34.783 -16.531 20.734 1.00 38.52 ? 27 ASP A OD1 1 ATOM 201 O OD2 . ASP A 1 27 ? -36.070 -14.749 20.746 1.00 42.89 ? 27 ASP A OD2 1 ATOM 202 N N . CYS A 1 28 ? -34.475 -17.569 16.235 1.00 36.55 ? 28 CYS A N 1 ATOM 203 C CA . CYS A 1 28 ? -34.945 -18.265 15.048 1.00 38.32 ? 28 CYS A CA 1 ATOM 204 C C . CYS A 1 28 ? -33.998 -17.951 13.859 1.00 37.79 ? 28 CYS A C 1 ATOM 205 O O . CYS A 1 28 ? -34.355 -18.193 12.704 1.00 38.44 ? 28 CYS A O 1 ATOM 206 C CB . CYS A 1 28 ? -36.433 -18.016 14.705 1.00 39.41 ? 28 CYS A CB 1 ATOM 207 S SG . CYS A 1 28 ? -37.581 -18.760 15.971 1.00 45.41 ? 28 CYS A SG 1 ATOM 208 N N . ASN A 1 29 ? -32.802 -17.419 14.138 1.00 36.57 ? 29 ASN A N 1 ATOM 209 C CA . ASN A 1 29 ? -31.763 -17.248 13.111 1.00 35.54 ? 29 ASN A CA 1 ATOM 210 C C . ASN A 1 29 ? -31.153 -18.606 12.763 1.00 35.95 ? 29 ASN A C 1 ATOM 211 O O . ASN A 1 29 ? -31.118 -18.994 11.594 1.00 35.68 ? 29 ASN A O 1 ATOM 212 C CB . ASN A 1 29 ? -30.684 -16.251 13.565 1.00 34.41 ? 29 ASN A CB 1 ATOM 213 C CG . ASN A 1 29 ? -29.670 -15.914 12.467 1.00 31.51 ? 29 ASN A CG 1 ATOM 214 O OD1 . ASN A 1 29 ? -28.929 -16.770 12.025 1.00 30.25 ? 29 ASN A OD1 1 ATOM 215 N ND2 . ASN A 1 29 ? -29.600 -14.649 12.074 1.00 26.31 ? 29 ASN A ND2 1 ATOM 216 N N . ASN A 1 30 ? -30.666 -19.317 13.780 1.00 36.23 ? 30 ASN A N 1 ATOM 217 C CA . ASN A 1 30 ? -30.318 -20.712 13.629 1.00 36.34 ? 30 ASN A CA 1 ATOM 218 C C . ASN A 1 30 ? -31.591 -21.502 13.831 1.00 37.07 ? 30 ASN A C 1 ATOM 219 O O . ASN A 1 30 ? -32.131 -21.489 14.937 1.00 37.27 ? 30 ASN A O 1 ATOM 220 C CB . ASN A 1 30 ? -29.289 -21.109 14.680 1.00 36.37 ? 30 ASN A CB 1 ATOM 221 C CG . ASN A 1 30 ? -28.620 -22.439 14.379 1.00 36.02 ? 30 ASN A CG 1 ATOM 222 O OD1 . ASN A 1 30 ? -29.275 -23.479 14.304 1.00 34.26 ? 30 ASN A OD1 1 ATOM 223 N ND2 . ASN A 1 30 ? -27.297 -22.408 14.207 1.00 35.41 ? 30 ASN A ND2 1 ATOM 224 N N . ARG A 1 31 ? -32.084 -22.170 12.777 1.00 38.05 ? 31 ARG A N 1 ATOM 225 C CA . ARG A 1 31 ? -33.351 -22.934 12.858 1.00 39.15 ? 31 ARG A CA 1 ATOM 226 C C . ARG A 1 31 ? -33.170 -24.260 13.598 1.00 39.51 ? 31 ARG A C 1 ATOM 227 O O . ARG A 1 31 ? -34.072 -24.738 14.298 1.00 39.45 ? 31 ARG A O 1 ATOM 228 C CB . ARG A 1 31 ? -33.979 -23.176 11.484 1.00 39.68 ? 31 ARG A CB 1 ATOM 229 C CG . ARG A 1 31 ? -34.302 -21.913 10.673 1.00 42.26 ? 31 ARG A CG 1 ATOM 230 C CD . ARG A 1 31 ? -35.710 -22.021 10.077 1.00 49.43 ? 31 ARG A CD 1 ATOM 231 N NE . ARG A 1 31 ? -35.926 -21.298 8.805 1.00 54.00 ? 31 ARG A NE 1 ATOM 232 C CZ . ARG A 1 31 ? -36.051 -21.886 7.607 1.00 55.36 ? 31 ARG A CZ 1 ATOM 233 N NH1 . ARG A 1 31 ? -35.976 -23.211 7.485 1.00 54.44 ? 31 ARG A NH1 1 ATOM 234 N NH2 . ARG A 1 31 ? -36.260 -21.146 6.522 1.00 55.16 ? 31 ARG A NH2 1 ATOM 235 N N . ARG A 1 32 ? -31.991 -24.847 13.454 1.00 39.78 ? 32 ARG A N 1 ATOM 236 C CA . ARG A 1 32 ? -31.674 -26.043 14.198 1.00 40.25 ? 32 ARG A CA 1 ATOM 237 C C . ARG A 1 32 ? -31.508 -25.725 15.688 1.00 39.16 ? 32 ARG A C 1 ATOM 238 O O . ARG A 1 32 ? -31.743 -26.574 16.515 1.00 39.00 ? 32 ARG A O 1 ATOM 239 C CB . ARG A 1 32 ? -30.435 -26.733 13.614 1.00 40.60 ? 32 ARG A CB 1 ATOM 240 C CG . ARG A 1 32 ? -30.309 -28.190 14.025 1.00 45.33 ? 32 ARG A CG 1 ATOM 241 C CD . ARG A 1 32 ? -28.917 -28.786 13.704 1.00 51.52 ? 32 ARG A CD 1 ATOM 242 N NE . ARG A 1 32 ? -28.713 -30.086 14.359 1.00 54.60 ? 32 ARG A NE 1 ATOM 243 C CZ . ARG A 1 32 ? -27.646 -30.865 14.189 1.00 56.85 ? 32 ARG A CZ 1 ATOM 244 N NH1 . ARG A 1 32 ? -26.662 -30.497 13.373 1.00 58.83 ? 32 ARG A NH1 1 ATOM 245 N NH2 . ARG A 1 32 ? -27.561 -32.018 14.835 1.00 57.70 ? 32 ARG A NH2 1 ATOM 246 N N . SER A 1 33 ? -31.025 -24.515 15.954 1.00 39.04 ? 33 SER A N 1 ATOM 247 C CA . SER A 1 33 ? -30.890 -23.945 17.285 1.00 38.73 ? 33 SER A CA 1 ATOM 248 C C . SER A 1 33 ? -31.471 -22.553 17.131 1.00 38.19 ? 33 SER A C 1 ATOM 249 O O . SER A 1 33 ? -31.067 -21.802 16.243 1.00 39.25 ? 33 SER A O 1 ATOM 250 C CB . SER A 1 33 ? -29.423 -23.873 17.700 1.00 38.58 ? 33 SER A CB 1 ATOM 251 O OG . SER A 1 33 ? -29.295 -23.799 19.109 1.00 40.28 ? 33 SER A OG 1 ATOM 252 N N . PRO A 1 34 ? -32.438 -22.215 17.972 1.00 37.33 ? 34 PRO A N 1 ATOM 253 C CA . PRO A 1 34 ? -33.352 -21.102 17.666 1.00 36.35 ? 34 PRO A CA 1 ATOM 254 C C . PRO A 1 34 ? -32.862 -19.936 18.539 1.00 35.40 ? 34 PRO A C 1 ATOM 255 O O . PRO A 1 34 ? -33.005 -18.776 18.141 1.00 35.53 ? 34 PRO A O 1 ATOM 256 C CB . PRO A 1 34 ? -34.825 -21.400 17.939 1.00 36.03 ? 34 PRO A CB 1 ATOM 257 C CG . PRO A 1 34 ? -34.976 -22.857 17.583 1.00 37.39 ? 34 PRO A CG 1 ATOM 258 C CD . PRO A 1 34 ? -33.701 -23.506 17.969 1.00 37.01 ? 34 PRO A CD 1 ATOM 259 N N . ALA A 1 35 ? -32.318 -20.227 19.710 1.00 34.32 ? 35 ALA A N 1 ATOM 260 C CA . ALA A 1 35 ? -31.921 -19.172 20.645 1.00 33.58 ? 35 ALA A CA 1 ATOM 261 C C . ALA A 1 35 ? -30.465 -18.688 20.462 1.00 32.53 ? 35 ALA A C 1 ATOM 262 O O . ALA A 1 35 ? -30.094 -17.631 20.947 1.00 32.48 ? 35 ALA A O 1 ATOM 263 C CB . ALA A 1 35 ? -32.196 -19.593 22.120 1.00 32.71 ? 35 ALA A CB 1 ATOM 264 N N . LEU A 1 36 ? -29.641 -19.448 19.764 1.00 32.21 ? 36 LEU A N 1 ATOM 265 C CA . LEU A 1 36 ? -28.286 -18.966 19.417 1.00 31.64 ? 36 LEU A CA 1 ATOM 266 C C . LEU A 1 36 ? -28.261 -17.563 18.825 1.00 31.25 ? 36 LEU A C 1 ATOM 267 O O . LEU A 1 36 ? -28.780 -17.339 17.729 1.00 30.83 ? 36 LEU A O 1 ATOM 268 C CB . LEU A 1 36 ? -27.632 -19.902 18.408 1.00 31.14 ? 36 LEU A CB 1 ATOM 269 C CG . LEU A 1 36 ? -27.104 -21.193 18.985 1.00 32.28 ? 36 LEU A CG 1 ATOM 270 C CD1 . LEU A 1 36 ? -26.795 -22.127 17.813 1.00 32.65 ? 36 LEU A CD1 1 ATOM 271 C CD2 . LEU A 1 36 ? -25.900 -21.009 19.946 1.00 28.26 ? 36 LEU A CD2 1 ATOM 272 N N . GLY A 1 37 ? -27.652 -16.625 19.540 1.00 31.63 ? 37 GLY A N 1 ATOM 273 C CA . GLY A 1 37 ? -27.422 -15.269 19.001 1.00 32.58 ? 37 GLY A CA 1 ATOM 274 C C . GLY A 1 37 ? -28.508 -14.263 19.354 1.00 33.09 ? 37 GLY A C 1 ATOM 275 O O . GLY A 1 37 ? -28.385 -13.062 19.062 1.00 32.94 ? 37 GLY A O 1 ATOM 276 N N . ALA A 1 38 ? -29.571 -14.763 19.981 1.00 32.56 ? 38 ALA A N 1 ATOM 277 C CA . ALA A 1 38 ? -30.650 -13.936 20.450 1.00 32.39 ? 38 ALA A CA 1 ATOM 278 C C . ALA A 1 38 ? -30.160 -13.092 21.610 1.00 32.32 ? 38 ALA A C 1 ATOM 279 O O . ALA A 1 38 ? -29.275 -13.506 22.352 1.00 33.01 ? 38 ALA A O 1 ATOM 280 C CB . ALA A 1 38 ? -31.793 -14.820 20.914 1.00 32.35 ? 38 ALA A CB 1 ATOM 281 N N . ALA A 1 39 ? -30.769 -11.935 21.804 1.00 32.09 ? 39 ALA A N 1 ATOM 282 C CA . ALA A 1 39 ? -30.508 -11.126 22.993 1.00 31.64 ? 39 ALA A CA 1 ATOM 283 C C . ALA A 1 39 ? -31.121 -11.759 24.208 1.00 31.87 ? 39 ALA A C 1 ATOM 284 O O . ALA A 1 39 ? -31.905 -12.716 24.112 1.00 32.11 ? 39 ALA A O 1 ATOM 285 C CB . ALA A 1 39 ? -31.066 -9.741 22.818 1.00 31.50 ? 39 ALA A CB 1 ATOM 286 N N . ASN A 1 40 ? -30.786 -11.180 25.353 1.00 31.80 ? 40 ASN A N 1 ATOM 287 C CA . ASN A 1 40 ? -31.211 -11.657 26.658 1.00 32.09 ? 40 ASN A CA 1 ATOM 288 C C . ASN A 1 40 ? -30.760 -13.066 27.054 1.00 31.12 ? 40 ASN A C 1 ATOM 289 O O . ASN A 1 40 ? -31.342 -13.692 27.931 1.00 31.40 ? 40 ASN A O 1 ATOM 290 C CB . ASN A 1 40 ? -32.698 -11.342 26.898 1.00 33.01 ? 40 ASN A CB 1 ATOM 291 C CG . ASN A 1 40 ? -32.971 -9.826 26.851 1.00 37.04 ? 40 ASN A CG 1 ATOM 292 O OD1 . ASN A 1 40 ? -32.117 -9.024 27.246 1.00 41.38 ? 40 ASN A OD1 1 ATOM 293 N ND2 . ASN A 1 40 ? -34.142 -9.431 26.350 1.00 40.73 ? 40 ASN A ND2 1 ATOM 294 N N . ARG A 1 41 ? -29.685 -13.537 26.425 1.00 29.97 ? 41 ARG A N 1 ATOM 295 C CA . ARG A 1 41 ? -29.037 -14.781 26.836 1.00 28.79 ? 41 ARG A CA 1 ATOM 296 C C . ARG A 1 41 ? -27.640 -14.487 27.375 1.00 27.15 ? 41 ARG A C 1 ATOM 297 O O . ARG A 1 41 ? -27.125 -13.366 27.226 1.00 25.77 ? 41 ARG A O 1 ATOM 298 C CB . ARG A 1 41 ? -28.930 -15.745 25.643 1.00 29.11 ? 41 ARG A CB 1 ATOM 299 C CG . ARG A 1 41 ? -30.213 -15.893 24.827 1.00 31.82 ? 41 ARG A CG 1 ATOM 300 C CD . ARG A 1 41 ? -31.161 -16.804 25.536 1.00 33.99 ? 41 ARG A CD 1 ATOM 301 N NE . ARG A 1 41 ? -32.447 -16.954 24.868 1.00 36.55 ? 41 ARG A NE 1 ATOM 302 C CZ . ARG A 1 41 ? -33.320 -17.912 25.186 1.00 38.44 ? 41 ARG A CZ 1 ATOM 303 N NH1 . ARG A 1 41 ? -33.014 -18.797 26.137 1.00 36.53 ? 41 ARG A NH1 1 ATOM 304 N NH2 . ARG A 1 41 ? -34.478 -18.010 24.535 1.00 39.55 ? 41 ARG A NH2 1 ATOM 305 N N . ALA A 1 42 ? -27.031 -15.496 27.993 1.00 25.76 ? 42 ALA A N 1 ATOM 306 C CA . ALA A 1 42 ? -25.658 -15.393 28.482 1.00 25.35 ? 42 ALA A CA 1 ATOM 307 C C . ALA A 1 42 ? -24.686 -15.100 27.323 1.00 25.00 ? 42 ALA A C 1 ATOM 308 O O . ALA A 1 42 ? -24.905 -15.566 26.214 1.00 24.55 ? 42 ALA A O 1 ATOM 309 C CB . ALA A 1 42 ? -25.272 -16.686 29.177 1.00 24.76 ? 42 ALA A CB 1 ATOM 310 N N . LEU A 1 43 ? -23.643 -14.299 27.571 1.00 25.00 ? 43 LEU A N 1 ATOM 311 C CA . LEU A 1 43 ? -22.481 -14.197 26.646 1.00 23.72 ? 43 LEU A CA 1 ATOM 312 C C . LEU A 1 43 ? -21.834 -15.579 26.574 1.00 24.33 ? 43 LEU A C 1 ATOM 313 O O . LEU A 1 43 ? -21.765 -16.283 27.590 1.00 24.45 ? 43 LEU A O 1 ATOM 314 C CB . LEU A 1 43 ? -21.448 -13.186 27.162 1.00 22.58 ? 43 LEU A CB 1 ATOM 315 C CG . LEU A 1 43 ? -21.818 -11.696 27.104 1.00 21.47 ? 43 LEU A CG 1 ATOM 316 C CD1 . LEU A 1 43 ? -21.056 -10.833 28.069 1.00 20.03 ? 43 LEU A CD1 1 ATOM 317 C CD2 . LEU A 1 43 ? -21.709 -11.103 25.704 1.00 19.96 ? 43 LEU A CD2 1 ATOM 318 N N . ALA A 1 44 ? -21.352 -15.975 25.392 1.00 23.97 ? 44 ALA A N 1 ATOM 319 C CA . ALA A 1 44 ? -20.609 -17.232 25.266 1.00 22.43 ? 44 ALA A CA 1 ATOM 320 C C . ALA A 1 44 ? -19.328 -17.229 26.101 1.00 22.17 ? 44 ALA A C 1 ATOM 321 O O . ALA A 1 44 ? -18.690 -16.189 26.266 1.00 22.80 ? 44 ALA A O 1 ATOM 322 C CB . ALA A 1 44 ? -20.286 -17.523 23.773 1.00 21.95 ? 44 ALA A CB 1 ATOM 323 N N . ARG A 1 45 ? -18.946 -18.384 26.612 1.00 22.18 ? 45 ARG A N 1 ATOM 324 C CA . ARG A 1 45 ? -17.635 -18.544 27.187 1.00 23.05 ? 45 ARG A CA 1 ATOM 325 C C . ARG A 1 45 ? -16.758 -19.332 26.216 1.00 23.34 ? 45 ARG A C 1 ATOM 326 O O . ARG A 1 45 ? -17.058 -20.491 25.929 1.00 24.20 ? 45 ARG A O 1 ATOM 327 C CB . ARG A 1 45 ? -17.694 -19.287 28.522 1.00 22.94 ? 45 ARG A CB 1 ATOM 328 C CG . ARG A 1 45 ? -18.317 -18.504 29.653 1.00 24.35 ? 45 ARG A CG 1 ATOM 329 C CD . ARG A 1 45 ? -17.340 -17.586 30.336 1.00 24.37 ? 45 ARG A CD 1 ATOM 330 N NE . ARG A 1 45 ? -18.044 -16.774 31.318 1.00 26.33 ? 45 ARG A NE 1 ATOM 331 C CZ . ARG A 1 45 ? -17.512 -15.749 31.975 1.00 27.58 ? 45 ARG A CZ 1 ATOM 332 N NH1 . ARG A 1 45 ? -16.250 -15.394 31.735 1.00 27.04 ? 45 ARG A NH1 1 ATOM 333 N NH2 . ARG A 1 45 ? -18.245 -15.076 32.858 1.00 25.32 ? 45 ARG A NH2 1 ATOM 334 N N . TRP A 1 46 ? -15.681 -18.714 25.742 1.00 22.77 ? 46 TRP A N 1 ATOM 335 C CA . TRP A 1 46 ? -14.701 -19.399 24.915 1.00 23.04 ? 46 TRP A CA 1 ATOM 336 C C . TRP A 1 46 ? -13.770 -20.155 25.810 1.00 23.26 ? 46 TRP A C 1 ATOM 337 O O . TRP A 1 46 ? -13.150 -21.125 25.401 1.00 24.15 ? 46 TRP A O 1 ATOM 338 C CB . TRP A 1 46 ? -13.896 -18.424 24.035 1.00 22.12 ? 46 TRP A CB 1 ATOM 339 C CG . TRP A 1 46 ? -14.666 -17.849 22.879 1.00 22.52 ? 46 TRP A CG 1 ATOM 340 C CD1 . TRP A 1 46 ? -15.891 -18.226 22.457 1.00 21.75 ? 46 TRP A CD1 1 ATOM 341 C CD2 . TRP A 1 46 ? -14.233 -16.818 21.977 1.00 22.95 ? 46 TRP A CD2 1 ATOM 342 N NE1 . TRP A 1 46 ? -16.273 -17.481 21.377 1.00 24.26 ? 46 TRP A NE1 1 ATOM 343 C CE2 . TRP A 1 46 ? -15.273 -16.603 21.065 1.00 22.90 ? 46 TRP A CE2 1 ATOM 344 C CE3 . TRP A 1 46 ? -13.077 -16.034 21.879 1.00 22.42 ? 46 TRP A CE3 1 ATOM 345 C CZ2 . TRP A 1 46 ? -15.192 -15.664 20.036 1.00 24.69 ? 46 TRP A CZ2 1 ATOM 346 C CZ3 . TRP A 1 46 ? -12.998 -15.076 20.863 1.00 25.06 ? 46 TRP A CZ3 1 ATOM 347 C CH2 . TRP A 1 46 ? -14.047 -14.913 19.942 1.00 24.08 ? 46 TRP A CH2 1 ATOM 348 N N . LEU A 1 47 ? -13.660 -19.677 27.039 1.00 23.38 ? 47 LEU A N 1 ATOM 349 C CA . LEU A 1 47 ? -12.818 -20.292 28.060 1.00 23.18 ? 47 LEU A CA 1 ATOM 350 C C . LEU A 1 47 ? -13.618 -20.209 29.334 1.00 22.29 ? 47 LEU A C 1 ATOM 351 O O . LEU A 1 47 ? -14.433 -19.291 29.471 1.00 23.14 ? 47 LEU A O 1 ATOM 352 C CB . LEU A 1 47 ? -11.512 -19.508 28.223 1.00 22.50 ? 47 LEU A CB 1 ATOM 353 C CG . LEU A 1 47 ? -10.367 -19.856 27.289 1.00 23.88 ? 47 LEU A CG 1 ATOM 354 C CD1 . LEU A 1 47 ? -9.133 -19.034 27.706 1.00 26.79 ? 47 LEU A CD1 1 ATOM 355 C CD2 . LEU A 1 47 ? -10.049 -21.352 27.297 1.00 23.20 ? 47 LEU A CD2 1 ATOM 356 N N . PRO A 1 48 ? -13.421 -21.150 30.260 1.00 21.56 ? 48 PRO A N 1 ATOM 357 C CA . PRO A 1 48 ? -14.191 -21.066 31.518 1.00 21.70 ? 48 PRO A CA 1 ATOM 358 C C . PRO A 1 48 ? -13.935 -19.801 32.362 1.00 21.38 ? 48 PRO A C 1 ATOM 359 O O . PRO A 1 48 ? -12.815 -19.324 32.481 1.00 21.17 ? 48 PRO A O 1 ATOM 360 C CB . PRO A 1 48 ? -13.729 -22.323 32.283 1.00 20.65 ? 48 PRO A CB 1 ATOM 361 C CG . PRO A 1 48 ? -13.413 -23.257 31.195 1.00 20.58 ? 48 PRO A CG 1 ATOM 362 C CD . PRO A 1 48 ? -12.650 -22.397 30.215 1.00 21.17 ? 48 PRO A CD 1 ATOM 363 N N . ALA A 1 49 ? -15.002 -19.285 32.938 1.00 22.53 ? 49 ALA A N 1 ATOM 364 C CA . ALA A 1 49 ? -14.935 -18.221 33.907 1.00 23.80 ? 49 ALA A CA 1 ATOM 365 C C . ALA A 1 49 ? -13.819 -18.477 34.943 1.00 25.25 ? 49 ALA A C 1 ATOM 366 O O . ALA A 1 49 ? -13.586 -19.621 35.337 1.00 25.40 ? 49 ALA A O 1 ATOM 367 C CB . ALA A 1 49 ? -16.283 -18.099 34.575 1.00 23.43 ? 49 ALA A CB 1 ATOM 368 N N . GLU A 1 50 ? -13.105 -17.418 35.338 1.00 26.34 ? 50 GLU A N 1 ATOM 369 C CA . GLU A 1 50 ? -12.133 -17.474 36.416 1.00 27.33 ? 50 GLU A CA 1 ATOM 370 C C . GLU A 1 50 ? -12.529 -16.444 37.477 1.00 28.63 ? 50 GLU A C 1 ATOM 371 O O . GLU A 1 50 ? -12.210 -15.250 37.358 1.00 29.50 ? 50 GLU A O 1 ATOM 372 C CB . GLU A 1 50 ? -10.700 -17.233 35.904 1.00 28.02 ? 50 GLU A CB 1 ATOM 373 C CG . GLU A 1 50 ? -10.217 -18.263 34.874 1.00 28.66 ? 50 GLU A CG 1 ATOM 374 C CD . GLU A 1 50 ? -8.709 -18.191 34.568 1.00 32.76 ? 50 GLU A CD 1 ATOM 375 O OE1 . GLU A 1 50 ? -7.998 -17.390 35.229 1.00 32.40 ? 50 GLU A OE1 1 ATOM 376 O OE2 . GLU A 1 50 ? -8.244 -18.938 33.648 1.00 30.53 ? 50 GLU A OE2 1 ATOM 377 N N . TYR A 1 51 ? -13.286 -16.913 38.471 1.00 29.02 ? 51 TYR A N 1 ATOM 378 C CA . TYR A 1 51 ? -13.674 -16.143 39.636 1.00 29.52 ? 51 TYR A CA 1 ATOM 379 C C . TYR A 1 51 ? -12.813 -16.551 40.812 1.00 30.80 ? 51 TYR A C 1 ATOM 380 O O . TYR A 1 51 ? -12.385 -17.710 40.896 1.00 29.89 ? 51 TYR A O 1 ATOM 381 C CB . TYR A 1 51 ? -15.129 -16.418 40.022 1.00 28.97 ? 51 TYR A CB 1 ATOM 382 C CG . TYR A 1 51 ? -16.111 -15.865 39.046 1.00 27.25 ? 51 TYR A CG 1 ATOM 383 C CD1 . TYR A 1 51 ? -16.893 -16.712 38.262 1.00 24.02 ? 51 TYR A CD1 1 ATOM 384 C CD2 . TYR A 1 51 ? -16.234 -14.497 38.872 1.00 24.95 ? 51 TYR A CD2 1 ATOM 385 C CE1 . TYR A 1 51 ? -17.788 -16.199 37.346 1.00 22.11 ? 51 TYR A CE1 1 ATOM 386 C CE2 . TYR A 1 51 ? -17.128 -13.990 37.951 1.00 25.61 ? 51 TYR A CE2 1 ATOM 387 C CZ . TYR A 1 51 ? -17.884 -14.845 37.206 1.00 22.05 ? 51 TYR A CZ 1 ATOM 388 O OH . TYR A 1 51 ? -18.763 -14.318 36.330 1.00 26.22 ? 51 TYR A OH 1 ATOM 389 N N . GLU A 1 52 ? -12.596 -15.599 41.723 1.00 31.59 ? 52 GLU A N 1 ATOM 390 C CA . GLU A 1 52 ? -11.947 -15.861 43.014 1.00 33.35 ? 52 GLU A CA 1 ATOM 391 C C . GLU A 1 52 ? -12.372 -17.162 43.720 1.00 34.38 ? 52 GLU A C 1 ATOM 392 O O . GLU A 1 52 ? -11.528 -17.880 44.273 1.00 34.42 ? 52 GLU A O 1 ATOM 393 C CB . GLU A 1 52 ? -12.229 -14.696 43.965 1.00 33.38 ? 52 GLU A CB 1 ATOM 394 C CG . GLU A 1 52 ? -11.423 -14.734 45.243 1.00 34.38 ? 52 GLU A CG 1 ATOM 395 C CD . GLU A 1 52 ? -11.510 -13.444 45.985 1.00 35.04 ? 52 GLU A CD 1 ATOM 396 O OE1 . GLU A 1 52 ? -12.554 -13.212 46.658 1.00 32.73 ? 52 GLU A OE1 1 ATOM 397 O OE2 . GLU A 1 52 ? -10.522 -12.672 45.878 1.00 35.68 ? 52 GLU A OE2 1 ATOM 398 N N . ASP A 1 53 ? -13.678 -17.424 43.743 1.00 35.63 ? 53 ASP A N 1 ATOM 399 C CA . ASP A 1 53 ? -14.245 -18.538 44.499 1.00 37.09 ? 53 ASP A CA 1 ATOM 400 C C . ASP A 1 53 ? -14.789 -19.602 43.535 1.00 38.06 ? 53 ASP A C 1 ATOM 401 O O . ASP A 1 53 ? -15.688 -20.388 43.901 1.00 38.43 ? 53 ASP A O 1 ATOM 402 C CB . ASP A 1 53 ? -15.387 -18.054 45.386 1.00 37.19 ? 53 ASP A CB 1 ATOM 403 C CG . ASP A 1 53 ? -16.596 -17.604 44.578 1.00 39.35 ? 53 ASP A CG 1 ATOM 404 O OD1 . ASP A 1 53 ? -16.423 -17.362 43.363 1.00 41.65 ? 53 ASP A OD1 1 ATOM 405 O OD2 . ASP A 1 53 ? -17.711 -17.479 45.142 1.00 40.86 ? 53 ASP A OD2 1 ATOM 406 N N . GLY A 1 54 ? -14.268 -19.601 42.300 1.00 37.64 ? 54 GLY A N 1 ATOM 407 C CA . GLY A 1 54 ? -14.666 -20.579 41.298 1.00 36.41 ? 54 GLY A CA 1 ATOM 408 C C . GLY A 1 54 ? -16.014 -20.290 40.681 1.00 35.57 ? 54 GLY A C 1 ATOM 409 O O . GLY A 1 54 ? -16.248 -20.635 39.532 1.00 35.82 ? 54 GLY A O 1 ATOM 410 N N . LEU A 1 55 ? -16.898 -19.649 41.432 1.00 34.87 ? 55 LEU A N 1 ATOM 411 C CA . LEU A 1 55 ? -18.298 -19.532 41.024 1.00 34.41 ? 55 LEU A CA 1 ATOM 412 C C . LEU A 1 55 ? -18.794 -18.157 40.571 1.00 33.79 ? 55 LEU A C 1 ATOM 413 O O . LEU A 1 55 ? -19.544 -18.067 39.588 1.00 33.59 ? 55 LEU A O 1 ATOM 414 C CB . LEU A 1 55 ? -19.211 -20.013 42.147 1.00 34.58 ? 55 LEU A CB 1 ATOM 415 C CG . LEU A 1 55 ? -19.553 -21.474 42.390 1.00 36.55 ? 55 LEU A CG 1 ATOM 416 C CD1 . LEU A 1 55 ? -20.722 -21.470 43.339 1.00 39.06 ? 55 LEU A CD1 1 ATOM 417 C CD2 . LEU A 1 55 ? -19.923 -22.251 41.121 1.00 37.46 ? 55 LEU A CD2 1 ATOM 418 N N . ALA A 1 56 ? -18.457 -17.123 41.321 1.00 33.24 ? 56 ALA A N 1 ATOM 419 C CA . ALA A 1 56 ? -18.920 -15.794 40.988 1.00 33.75 ? 56 ALA A CA 1 ATOM 420 C C . ALA A 1 56 ? -18.550 -14.841 42.100 1.00 34.27 ? 56 ALA A C 1 ATOM 421 O O . ALA A 1 56 ? -19.396 -14.344 42.844 1.00 34.29 ? 56 ALA A O 1 ATOM 422 C CB . ALA A 1 56 ? -20.423 -15.796 40.764 1.00 33.26 ? 56 ALA A CB 1 ATOM 423 N N . LEU A 1 57 ? -17.270 -14.584 42.201 1.00 35.04 ? 57 LEU A N 1 ATOM 424 C CA . LEU A 1 57 ? -16.685 -13.580 43.054 1.00 35.34 ? 57 LEU A CA 1 ATOM 425 C C . LEU A 1 57 ? -15.509 -13.115 42.257 1.00 35.62 ? 57 LEU A C 1 ATOM 426 O O . LEU A 1 57 ? -14.752 -13.898 41.760 1.00 35.90 ? 57 LEU A O 1 ATOM 427 C CB . LEU A 1 57 ? -16.229 -14.122 44.379 1.00 35.69 ? 57 LEU A CB 1 ATOM 428 C CG . LEU A 1 57 ? -17.099 -13.997 45.590 1.00 34.41 ? 57 LEU A CG 1 ATOM 429 C CD1 . LEU A 1 57 ? -16.307 -14.487 46.679 1.00 34.60 ? 57 LEU A CD1 1 ATOM 430 C CD2 . LEU A 1 57 ? -17.493 -12.637 45.833 1.00 33.19 ? 57 LEU A CD2 1 ATOM 431 N N . PRO A 1 58 ? -15.340 -11.832 42.131 1.00 36.04 ? 58 PRO A N 1 ATOM 432 C CA . PRO A 1 58 ? -14.263 -11.370 41.261 1.00 35.89 ? 58 PRO A CA 1 ATOM 433 C C . PRO A 1 58 ? -12.944 -11.392 41.982 1.00 36.61 ? 58 PRO A C 1 ATOM 434 O O . PRO A 1 58 ? -12.881 -11.195 43.201 1.00 37.32 ? 58 PRO A O 1 ATOM 435 C CB . PRO A 1 58 ? -14.663 -9.934 40.945 1.00 35.68 ? 58 PRO A CB 1 ATOM 436 C CG . PRO A 1 58 ? -15.539 -9.527 42.109 1.00 35.29 ? 58 PRO A CG 1 ATOM 437 C CD . PRO A 1 58 ? -16.282 -10.754 42.485 1.00 35.68 ? 58 PRO A CD 1 ATOM 438 N N . PHE A 1 59 ? -11.882 -11.636 41.234 1.00 37.01 ? 59 PHE A N 1 ATOM 439 C CA . PHE A 1 59 ? -10.553 -11.427 41.759 1.00 36.72 ? 59 PHE A CA 1 ATOM 440 C C . PHE A 1 59 ? -10.422 -9.957 42.152 1.00 37.38 ? 59 PHE A C 1 ATOM 441 O O . PHE A 1 59 ? -10.833 -9.075 41.380 1.00 36.52 ? 59 PHE A O 1 ATOM 442 C CB . PHE A 1 59 ? -9.530 -11.814 40.715 1.00 36.52 ? 59 PHE A CB 1 ATOM 443 C CG . PHE A 1 59 ? -9.339 -13.280 40.592 1.00 36.18 ? 59 PHE A CG 1 ATOM 444 C CD1 . PHE A 1 59 ? -9.963 -13.993 39.582 1.00 35.25 ? 59 PHE A CD1 1 ATOM 445 C CD2 . PHE A 1 59 ? -8.533 -13.967 41.501 1.00 37.15 ? 59 PHE A CD2 1 ATOM 446 C CE1 . PHE A 1 59 ? -9.780 -15.359 39.476 1.00 34.65 ? 59 PHE A CE1 1 ATOM 447 C CE2 . PHE A 1 59 ? -8.345 -15.344 41.395 1.00 35.60 ? 59 PHE A CE2 1 ATOM 448 C CZ . PHE A 1 59 ? -8.963 -16.034 40.379 1.00 34.50 ? 59 PHE A CZ 1 ATOM 449 N N . GLY A 1 60 ? -9.881 -9.725 43.359 1.00 38.14 ? 60 GLY A N 1 ATOM 450 C CA . GLY A 1 60 ? -9.835 -8.417 44.002 1.00 39.06 ? 60 GLY A CA 1 ATOM 451 C C . GLY A 1 60 ? -10.871 -8.186 45.095 1.00 40.55 ? 60 GLY A C 1 ATOM 452 O O . GLY A 1 60 ? -10.749 -7.232 45.864 1.00 41.31 ? 60 GLY A O 1 ATOM 453 N N . TRP A 1 61 ? -11.885 -9.050 45.176 1.00 40.98 ? 61 TRP A N 1 ATOM 454 C CA . TRP A 1 61 ? -12.999 -8.893 46.138 1.00 41.67 ? 61 TRP A CA 1 ATOM 455 C C . TRP A 1 61 ? -12.591 -9.101 47.604 1.00 42.60 ? 61 TRP A C 1 ATOM 456 O O . TRP A 1 61 ? -12.930 -8.301 48.471 1.00 42.50 ? 61 TRP A O 1 ATOM 457 C CB . TRP A 1 61 ? -14.129 -9.858 45.760 1.00 41.17 ? 61 TRP A CB 1 ATOM 458 C CG . TRP A 1 61 ? -15.421 -9.812 46.560 1.00 40.70 ? 61 TRP A CG 1 ATOM 459 C CD1 . TRP A 1 61 ? -15.710 -10.539 47.683 1.00 41.05 ? 61 TRP A CD1 1 ATOM 460 C CD2 . TRP A 1 61 ? -16.622 -9.075 46.249 1.00 38.20 ? 61 TRP A CD2 1 ATOM 461 N NE1 . TRP A 1 61 ? -16.991 -10.285 48.096 1.00 40.33 ? 61 TRP A NE1 1 ATOM 462 C CE2 . TRP A 1 61 ? -17.574 -9.390 47.243 1.00 38.54 ? 61 TRP A CE2 1 ATOM 463 C CE3 . TRP A 1 61 ? -16.973 -8.173 45.244 1.00 35.81 ? 61 TRP A CE3 1 ATOM 464 C CZ2 . TRP A 1 61 ? -18.853 -8.826 47.269 1.00 38.63 ? 61 TRP A CZ2 1 ATOM 465 C CZ3 . TRP A 1 61 ? -18.247 -7.602 45.270 1.00 38.24 ? 61 TRP A CZ3 1 ATOM 466 C CH2 . TRP A 1 61 ? -19.178 -7.937 46.272 1.00 37.74 ? 61 TRP A CH2 1 ATOM 467 N N . THR A 1 62 ? -11.891 -10.191 47.885 1.00 43.92 ? 62 THR A N 1 ATOM 468 C CA . THR A 1 62 ? -11.561 -10.536 49.260 1.00 44.93 ? 62 THR A CA 1 ATOM 469 C C . THR A 1 62 ? -10.104 -10.149 49.468 1.00 45.96 ? 62 THR A C 1 ATOM 470 O O . THR A 1 62 ? -9.208 -10.744 48.865 1.00 45.82 ? 62 THR A O 1 ATOM 471 C CB . THR A 1 62 ? -11.815 -12.031 49.547 1.00 44.84 ? 62 THR A CB 1 ATOM 472 O OG1 . THR A 1 62 ? -13.225 -12.290 49.470 1.00 44.71 ? 62 THR A OG1 1 ATOM 473 C CG2 . THR A 1 62 ? -11.285 -12.431 50.929 1.00 43.95 ? 62 THR A CG2 1 ATOM 474 N N . GLN A 1 63 ? -9.886 -9.140 50.313 1.00 46.94 ? 63 GLN A N 1 ATOM 475 C CA . GLN A 1 63 ? -8.577 -8.517 50.475 1.00 48.22 ? 63 GLN A CA 1 ATOM 476 C C . GLN A 1 63 ? -7.463 -9.567 50.389 1.00 48.31 ? 63 GLN A C 1 ATOM 477 O O . GLN A 1 63 ? -6.561 -9.473 49.537 1.00 48.63 ? 63 GLN A O 1 ATOM 478 C CB . GLN A 1 63 ? -8.515 -7.747 51.812 1.00 48.86 ? 63 GLN A CB 1 ATOM 479 C CG . GLN A 1 63 ? -7.560 -6.521 51.840 1.00 50.90 ? 63 GLN A CG 1 ATOM 480 C CD . GLN A 1 63 ? -8.210 -5.223 51.309 1.00 54.77 ? 63 GLN A CD 1 ATOM 481 O OE1 . GLN A 1 63 ? -8.962 -5.230 50.317 1.00 55.52 ? 63 GLN A OE1 1 ATOM 482 N NE2 . GLN A 1 63 ? -7.905 -4.102 51.964 1.00 54.36 ? 63 GLN A NE2 1 ATOM 483 N N . ARG A 1 64 ? -7.596 -10.589 51.239 1.00 48.10 ? 64 ARG A N 1 ATOM 484 C CA . ARG A 1 64 ? -6.558 -11.579 51.540 1.00 47.75 ? 64 ARG A CA 1 ATOM 485 C C . ARG A 1 64 ? -6.417 -12.753 50.539 1.00 46.94 ? 64 ARG A C 1 ATOM 486 O O . ARG A 1 64 ? -5.473 -13.552 50.645 1.00 47.06 ? 64 ARG A O 1 ATOM 487 C CB . ARG A 1 64 ? -6.835 -12.149 52.935 1.00 48.15 ? 64 ARG A CB 1 ATOM 488 C CG . ARG A 1 64 ? -8.049 -13.059 52.972 1.00 48.51 ? 64 ARG A CG 1 ATOM 489 C CD . ARG A 1 64 ? -8.204 -13.702 54.332 1.00 51.42 ? 64 ARG A CD 1 ATOM 490 N NE . ARG A 1 64 ? -8.600 -15.112 54.267 1.00 51.31 ? 64 ARG A NE 1 ATOM 491 C CZ . ARG A 1 64 ? -9.825 -15.548 53.984 1.00 51.17 ? 64 ARG A CZ 1 ATOM 492 N NH1 . ARG A 1 64 ? -10.804 -14.695 53.706 1.00 48.48 ? 64 ARG A NH1 1 ATOM 493 N NH2 . ARG A 1 64 ? -10.064 -16.858 53.968 1.00 52.78 ? 64 ARG A NH2 1 ATOM 494 N N . LYS A 1 65 ? -7.371 -12.863 49.613 1.00 45.64 ? 65 LYS A N 1 ATOM 495 C CA . LYS A 1 65 ? -7.388 -13.899 48.579 1.00 44.06 ? 65 LYS A CA 1 ATOM 496 C C . LYS A 1 65 ? -6.735 -13.406 47.291 1.00 42.93 ? 65 LYS A C 1 ATOM 497 O O . LYS A 1 65 ? -7.188 -12.432 46.678 1.00 43.41 ? 65 LYS A O 1 ATOM 498 C CB . LYS A 1 65 ? -8.823 -14.329 48.287 1.00 44.06 ? 65 LYS A CB 1 ATOM 499 C CG . LYS A 1 65 ? -9.464 -15.156 49.358 1.00 45.20 ? 65 LYS A CG 1 ATOM 500 C CD . LYS A 1 65 ? -9.532 -16.636 49.041 1.00 48.18 ? 65 LYS A CD 1 ATOM 501 C CE . LYS A 1 65 ? -10.616 -17.277 49.926 1.00 50.12 ? 65 LYS A CE 1 ATOM 502 N NZ . LYS A 1 65 ? -10.745 -18.751 49.734 1.00 51.42 ? 65 LYS A NZ 1 ATOM 503 N N . THR A 1 66 ? -5.695 -14.106 46.868 1.00 41.07 ? 66 THR A N 1 ATOM 504 C CA . THR A 1 66 ? -4.881 -13.691 45.731 1.00 39.49 ? 66 THR A CA 1 ATOM 505 C C . THR A 1 66 ? -5.363 -14.222 44.360 1.00 38.47 ? 66 THR A C 1 ATOM 506 O O . THR A 1 66 ? -6.361 -14.956 44.263 1.00 39.02 ? 66 THR A O 1 ATOM 507 C CB . THR A 1 66 ? -3.405 -14.170 45.921 1.00 39.54 ? 66 THR A CB 1 ATOM 508 O OG1 . THR A 1 66 ? -3.368 -15.602 45.973 1.00 37.78 ? 66 THR A OG1 1 ATOM 509 C CG2 . THR A 1 66 ? -2.767 -13.571 47.206 1.00 39.61 ? 66 THR A CG2 1 ATOM 510 N N . ARG A 1 67 ? -4.642 -13.823 43.309 1.00 35.93 ? 67 ARG A N 1 ATOM 511 C CA . ARG A 1 67 ? -4.643 -14.527 42.037 1.00 33.24 ? 67 ARG A CA 1 ATOM 512 C C . ARG A 1 67 ? -3.239 -15.048 41.798 1.00 31.50 ? 67 ARG A C 1 ATOM 513 O O . ARG A 1 67 ? -2.285 -14.282 41.841 1.00 30.03 ? 67 ARG A O 1 ATOM 514 C CB . ARG A 1 67 ? -5.039 -13.610 40.885 1.00 33.55 ? 67 ARG A CB 1 ATOM 515 C CG . ARG A 1 67 ? -5.269 -14.322 39.577 1.00 31.32 ? 67 ARG A CG 1 ATOM 516 C CD . ARG A 1 67 ? -5.870 -13.359 38.545 1.00 33.41 ? 67 ARG A CD 1 ATOM 517 N NE . ARG A 1 67 ? -6.483 -14.084 37.429 1.00 34.97 ? 67 ARG A NE 1 ATOM 518 C CZ . ARG A 1 67 ? -7.365 -13.574 36.575 1.00 34.26 ? 67 ARG A CZ 1 ATOM 519 N NH1 . ARG A 1 67 ? -7.753 -12.316 36.693 1.00 32.70 ? 67 ARG A NH1 1 ATOM 520 N NH2 . ARG A 1 67 ? -7.870 -14.340 35.604 1.00 32.97 ? 67 ARG A NH2 1 ATOM 521 N N . ASN A 1 68 ? -3.142 -16.350 41.521 1.00 29.61 ? 68 ASN A N 1 ATOM 522 C CA . ASN A 1 68 ? -1.872 -17.049 41.380 1.00 28.26 ? 68 ASN A CA 1 ATOM 523 C C . ASN A 1 68 ? -0.797 -16.644 42.396 1.00 27.66 ? 68 ASN A C 1 ATOM 524 O O . ASN A 1 68 ? 0.401 -16.623 42.072 1.00 26.98 ? 68 ASN A O 1 ATOM 525 C CB . ASN A 1 68 ? -1.350 -16.932 39.960 1.00 28.07 ? 68 ASN A CB 1 ATOM 526 C CG . ASN A 1 68 ? -2.363 -17.332 38.956 1.00 27.59 ? 68 ASN A CG 1 ATOM 527 O OD1 . ASN A 1 68 ? -2.786 -18.477 38.933 1.00 31.36 ? 68 ASN A OD1 1 ATOM 528 N ND2 . ASN A 1 68 ? -2.792 -16.391 38.131 1.00 24.03 ? 68 ASN A ND2 1 ATOM 529 N N . GLY A 1 69 ? -1.254 -16.326 43.607 1.00 27.39 ? 69 GLY A N 1 ATOM 530 C CA . GLY A 1 69 ? -0.396 -16.056 44.744 1.00 28.48 ? 69 GLY A CA 1 ATOM 531 C C . GLY A 1 69 ? -0.106 -14.587 44.965 1.00 29.93 ? 69 GLY A C 1 ATOM 532 O O . GLY A 1 69 ? 0.700 -14.234 45.824 1.00 30.28 ? 69 GLY A O 1 ATOM 533 N N . PHE A 1 70 ? -0.741 -13.717 44.186 1.00 30.73 ? 70 PHE A N 1 ATOM 534 C CA . PHE A 1 70 ? -0.502 -12.271 44.316 1.00 31.14 ? 70 PHE A CA 1 ATOM 535 C C . PHE A 1 70 ? -1.789 -11.464 44.436 1.00 31.43 ? 70 PHE A C 1 ATOM 536 O O . PHE A 1 70 ? -2.876 -11.950 44.122 1.00 31.72 ? 70 PHE A O 1 ATOM 537 C CB . PHE A 1 70 ? 0.377 -11.765 43.186 1.00 30.59 ? 70 PHE A CB 1 ATOM 538 C CG . PHE A 1 70 ? 1.703 -12.482 43.096 1.00 31.98 ? 70 PHE A CG 1 ATOM 539 C CD1 . PHE A 1 70 ? 1.870 -13.569 42.253 1.00 31.09 ? 70 PHE A CD1 1 ATOM 540 C CD2 . PHE A 1 70 ? 2.779 -12.080 43.871 1.00 32.43 ? 70 PHE A CD2 1 ATOM 541 C CE1 . PHE A 1 70 ? 3.080 -14.218 42.175 1.00 32.63 ? 70 PHE A CE1 1 ATOM 542 C CE2 . PHE A 1 70 ? 4.002 -12.745 43.800 1.00 32.04 ? 70 PHE A CE2 1 ATOM 543 C CZ . PHE A 1 70 ? 4.151 -13.808 42.953 1.00 32.08 ? 70 PHE A CZ 1 ATOM 544 N N . ARG A 1 71 ? -1.683 -10.255 44.961 1.00 31.80 ? 71 ARG A N 1 ATOM 545 C CA . ARG A 1 71 ? -2.836 -9.397 44.988 1.00 32.42 ? 71 ARG A CA 1 ATOM 546 C C . ARG A 1 71 ? -2.964 -8.816 43.626 1.00 31.40 ? 71 ARG A C 1 ATOM 547 O O . ARG A 1 71 ? -1.971 -8.619 42.896 1.00 31.45 ? 71 ARG A O 1 ATOM 548 C CB . ARG A 1 71 ? -2.715 -8.294 46.036 1.00 33.70 ? 71 ARG A CB 1 ATOM 549 C CG . ARG A 1 71 ? -3.089 -8.742 47.442 1.00 38.10 ? 71 ARG A CG 1 ATOM 550 C CD . ARG A 1 71 ? -2.188 -8.048 48.474 1.00 44.21 ? 71 ARG A CD 1 ATOM 551 N NE . ARG A 1 71 ? -2.828 -6.925 49.159 1.00 48.63 ? 71 ARG A NE 1 ATOM 552 C CZ . ARG A 1 71 ? -3.756 -7.056 50.112 1.00 50.97 ? 71 ARG A CZ 1 ATOM 553 N NH1 . ARG A 1 71 ? -4.185 -8.262 50.477 1.00 50.48 ? 71 ARG A NH1 1 ATOM 554 N NH2 . ARG A 1 71 ? -4.271 -5.974 50.693 1.00 51.78 ? 71 ARG A NH2 1 ATOM 555 N N . VAL A 1 72 ? -4.203 -8.584 43.252 1.00 30.70 ? 72 VAL A N 1 ATOM 556 C CA . VAL A 1 72 ? -4.434 -7.900 42.013 1.00 30.64 ? 72 VAL A CA 1 ATOM 557 C C . VAL A 1 72 ? -4.337 -6.407 42.266 1.00 30.37 ? 72 VAL A C 1 ATOM 558 O O . VAL A 1 72 ? -4.836 -5.902 43.275 1.00 30.55 ? 72 VAL A O 1 ATOM 559 C CB . VAL A 1 72 ? -5.742 -8.322 41.333 1.00 30.81 ? 72 VAL A CB 1 ATOM 560 C CG1 . VAL A 1 72 ? -5.652 -9.808 40.978 1.00 29.81 ? 72 VAL A CG1 1 ATOM 561 C CG2 . VAL A 1 72 ? -6.968 -8.004 42.237 1.00 29.98 ? 72 VAL A CG2 1 ATOM 562 N N . PRO A 1 73 ? -3.643 -5.696 41.378 1.00 29.78 ? 73 PRO A N 1 ATOM 563 C CA . PRO A 1 73 ? -3.566 -4.251 41.617 1.00 30.02 ? 73 PRO A CA 1 ATOM 564 C C . PRO A 1 73 ? -4.958 -3.586 41.499 1.00 30.47 ? 73 PRO A C 1 ATOM 565 O O . PRO A 1 73 ? -5.865 -4.136 40.829 1.00 30.60 ? 73 PRO A O 1 ATOM 566 C CB . PRO A 1 73 ? -2.589 -3.764 40.548 1.00 29.90 ? 73 PRO A CB 1 ATOM 567 C CG . PRO A 1 73 ? -2.567 -4.840 39.519 1.00 30.07 ? 73 PRO A CG 1 ATOM 568 C CD . PRO A 1 73 ? -2.859 -6.137 40.219 1.00 28.92 ? 73 PRO A CD 1 ATOM 569 N N . LEU A 1 74 ? -5.153 -2.456 42.183 1.00 30.14 ? 74 LEU A N 1 ATOM 570 C CA . LEU A 1 74 ? -6.452 -1.776 42.116 1.00 29.47 ? 74 LEU A CA 1 ATOM 571 C C . LEU A 1 74 ? -6.623 -1.199 40.716 1.00 28.71 ? 74 LEU A C 1 ATOM 572 O O . LEU A 1 74 ? -5.714 -0.528 40.204 1.00 29.26 ? 74 LEU A O 1 ATOM 573 C CB . LEU A 1 74 ? -6.579 -0.685 43.190 1.00 29.38 ? 74 LEU A CB 1 ATOM 574 C CG . LEU A 1 74 ? -6.641 -1.024 44.707 1.00 30.46 ? 74 LEU A CG 1 ATOM 575 C CD1 . LEU A 1 74 ? -6.089 0.176 45.545 1.00 30.26 ? 74 LEU A CD1 1 ATOM 576 C CD2 . LEU A 1 74 ? -8.041 -1.396 45.196 1.00 29.07 ? 74 LEU A CD2 1 ATOM 577 N N . ALA A 1 75 ? -7.760 -1.474 40.082 1.00 27.58 ? 75 ALA A N 1 ATOM 578 C CA . ALA A 1 75 ? -8.070 -0.894 38.766 1.00 26.88 ? 75 ALA A CA 1 ATOM 579 C C . ALA A 1 75 ? -7.556 0.530 38.607 1.00 26.49 ? 75 ALA A C 1 ATOM 580 O O . ALA A 1 75 ? -6.832 0.837 37.666 1.00 26.31 ? 75 ALA A O 1 ATOM 581 C CB . ALA A 1 75 ? -9.534 -0.923 38.519 1.00 27.32 ? 75 ALA A CB 1 ATOM 582 N N . ARG A 1 76 ? -7.878 1.387 39.563 1.00 26.43 ? 76 ARG A N 1 ATOM 583 C CA . ARG A 1 76 ? -7.534 2.807 39.446 1.00 26.61 ? 76 ARG A CA 1 ATOM 584 C C . ARG A 1 76 ? -6.028 3.050 39.448 1.00 26.67 ? 76 ARG A C 1 ATOM 585 O O . ARG A 1 76 ? -5.557 3.993 38.784 1.00 26.60 ? 76 ARG A O 1 ATOM 586 C CB . ARG A 1 76 ? -8.276 3.658 40.480 1.00 25.80 ? 76 ARG A CB 1 ATOM 587 C CG . ARG A 1 76 ? -7.784 5.078 40.626 1.00 25.11 ? 76 ARG A CG 1 ATOM 588 C CD . ARG A 1 76 ? -8.160 5.952 39.447 1.00 25.46 ? 76 ARG A CD 1 ATOM 589 N NE . ARG A 1 76 ? -7.818 7.359 39.656 1.00 22.86 ? 76 ARG A NE 1 ATOM 590 C CZ . ARG A 1 76 ? -8.205 8.351 38.852 1.00 23.99 ? 76 ARG A CZ 1 ATOM 591 N NH1 . ARG A 1 76 ? -8.930 8.089 37.747 1.00 22.35 ? 76 ARG A NH1 1 ATOM 592 N NH2 . ARG A 1 76 ? -7.848 9.603 39.139 1.00 20.82 ? 76 ARG A NH2 1 ATOM 593 N N . GLU A 1 77 ? -5.288 2.187 40.153 1.00 26.53 ? 77 GLU A N 1 ATOM 594 C CA . GLU A 1 77 ? -3.836 2.311 40.230 1.00 26.79 ? 77 GLU A CA 1 ATOM 595 C C . GLU A 1 77 ? -3.186 1.933 38.885 1.00 25.97 ? 77 GLU A C 1 ATOM 596 O O . GLU A 1 77 ? -2.336 2.671 38.367 1.00 26.49 ? 77 GLU A O 1 ATOM 597 C CB . GLU A 1 77 ? -3.239 1.490 41.397 1.00 27.13 ? 77 GLU A CB 1 ATOM 598 C CG . GLU A 1 77 ? -1.737 1.724 41.570 1.00 30.01 ? 77 GLU A CG 1 ATOM 599 C CD . GLU A 1 77 ? -1.096 1.054 42.799 1.00 35.63 ? 77 GLU A CD 1 ATOM 600 O OE1 . GLU A 1 77 ? -1.789 0.729 43.810 1.00 33.61 ? 77 GLU A OE1 1 ATOM 601 O OE2 . GLU A 1 77 ? 0.154 0.898 42.746 1.00 35.88 ? 77 GLU A OE2 1 ATOM 602 N N . VAL A 1 78 ? -3.575 0.797 38.329 1.00 24.81 ? 78 VAL A N 1 ATOM 603 C CA . VAL A 1 78 ? -3.195 0.467 36.939 1.00 24.81 ? 78 VAL A CA 1 ATOM 604 C C . VAL A 1 78 ? -3.540 1.615 35.999 1.00 24.34 ? 78 VAL A C 1 ATOM 605 O O . VAL A 1 78 ? -2.729 2.007 35.158 1.00 25.08 ? 78 VAL A O 1 ATOM 606 C CB . VAL A 1 78 ? -3.840 -0.861 36.428 1.00 25.19 ? 78 VAL A CB 1 ATOM 607 C CG1 . VAL A 1 78 ? -3.346 -1.205 35.041 1.00 23.68 ? 78 VAL A CG1 1 ATOM 608 C CG2 . VAL A 1 78 ? -3.573 -2.032 37.420 1.00 23.52 ? 78 VAL A CG2 1 ATOM 609 N N . SER A 1 79 ? -4.725 2.174 36.164 1.00 24.46 ? 79 SER A N 1 ATOM 610 C CA . SER A 1 79 ? -5.128 3.325 35.367 1.00 25.04 ? 79 SER A CA 1 ATOM 611 C C . SER A 1 79 ? -4.234 4.562 35.545 1.00 25.81 ? 79 SER A C 1 ATOM 612 O O . SER A 1 79 ? -3.901 5.222 34.548 1.00 26.77 ? 79 SER A O 1 ATOM 613 C CB . SER A 1 79 ? -6.568 3.679 35.619 1.00 24.39 ? 79 SER A CB 1 ATOM 614 O OG . SER A 1 79 ? -6.847 4.929 35.047 1.00 24.17 ? 79 SER A OG 1 ATOM 615 N N . ASN A 1 80 ? -3.840 4.876 36.778 1.00 25.69 ? 80 ASN A N 1 ATOM 616 C CA . ASN A 1 80 ? -2.900 5.995 37.027 1.00 25.90 ? 80 ASN A CA 1 ATOM 617 C C . ASN A 1 80 ? -1.498 5.706 36.549 1.00 26.22 ? 80 ASN A C 1 ATOM 618 O O . ASN A 1 80 ? -0.830 6.587 36.012 1.00 26.71 ? 80 ASN A O 1 ATOM 619 C CB . ASN A 1 80 ? -2.821 6.364 38.515 1.00 25.22 ? 80 ASN A CB 1 ATOM 620 C CG . ASN A 1 80 ? -4.161 6.822 39.079 1.00 26.29 ? 80 ASN A CG 1 ATOM 621 O OD1 . ASN A 1 80 ? -5.065 7.208 38.337 1.00 28.37 ? 80 ASN A OD1 1 ATOM 622 N ND2 . ASN A 1 80 ? -4.295 6.775 40.392 1.00 25.62 ? 80 ASN A ND2 1 ATOM 623 N N . LYS A 1 81 ? -1.040 4.485 36.760 1.00 26.38 ? 81 LYS A N 1 ATOM 624 C CA . LYS A 1 81 ? 0.372 4.208 36.557 1.00 27.74 ? 81 LYS A CA 1 ATOM 625 C C . LYS A 1 81 ? 0.744 3.827 35.135 1.00 27.27 ? 81 LYS A C 1 ATOM 626 O O . LYS A 1 81 ? 1.895 3.942 34.766 1.00 26.85 ? 81 LYS A O 1 ATOM 627 C CB . LYS A 1 81 ? 0.889 3.135 37.538 1.00 27.88 ? 81 LYS A CB 1 ATOM 628 C CG . LYS A 1 81 ? 1.283 3.711 38.884 1.00 29.66 ? 81 LYS A CG 1 ATOM 629 C CD . LYS A 1 81 ? 1.504 2.588 39.868 1.00 31.84 ? 81 LYS A CD 1 ATOM 630 C CE . LYS A 1 81 ? 2.050 3.080 41.195 1.00 30.01 ? 81 LYS A CE 1 ATOM 631 N NZ . LYS A 1 81 ? 2.017 1.871 42.088 1.00 30.56 ? 81 LYS A NZ 1 ATOM 632 N N . ILE A 1 82 ? -0.231 3.325 34.383 1.00 27.28 ? 82 ILE A N 1 ATOM 633 C CA . ILE A 1 82 ? -0.007 2.834 33.040 1.00 26.86 ? 82 ILE A CA 1 ATOM 634 C C . ILE A 1 82 ? -0.880 3.538 31.997 1.00 27.07 ? 82 ILE A C 1 ATOM 635 O O . ILE A 1 82 ? -0.401 3.836 30.895 1.00 27.32 ? 82 ILE A O 1 ATOM 636 C CB . ILE A 1 82 ? -0.259 1.308 32.992 1.00 27.50 ? 82 ILE A CB 1 ATOM 637 C CG1 . ILE A 1 82 ? 0.736 0.590 33.905 1.00 27.85 ? 82 ILE A CG1 1 ATOM 638 C CG2 . ILE A 1 82 ? -0.225 0.753 31.540 1.00 25.35 ? 82 ILE A CG2 1 ATOM 639 C CD1 . ILE A 1 82 ? 0.313 -0.808 34.212 1.00 31.08 ? 82 ILE A CD1 1 ATOM 640 N N . VAL A 1 83 ? -2.145 3.806 32.327 1.00 26.57 ? 83 VAL A N 1 ATOM 641 C CA . VAL A 1 83 ? -3.094 4.237 31.294 1.00 26.93 ? 83 VAL A CA 1 ATOM 642 C C . VAL A 1 83 ? -3.044 5.727 31.064 1.00 26.89 ? 83 VAL A C 1 ATOM 643 O O . VAL A 1 83 ? -3.248 6.175 29.954 1.00 27.17 ? 83 VAL A O 1 ATOM 644 C CB . VAL A 1 83 ? -4.561 3.768 31.589 1.00 26.94 ? 83 VAL A CB 1 ATOM 645 C CG1 . VAL A 1 83 ? -5.478 4.236 30.558 1.00 25.90 ? 83 VAL A CG1 1 ATOM 646 C CG2 . VAL A 1 83 ? -4.640 2.263 31.618 1.00 27.89 ? 83 VAL A CG2 1 ATOM 647 N N . GLY A 1 84 ? -2.747 6.483 32.114 1.00 27.56 ? 84 GLY A N 1 ATOM 648 C CA . GLY A 1 84 ? -2.761 7.940 32.071 1.00 27.68 ? 84 GLY A CA 1 ATOM 649 C C . GLY A 1 84 ? -1.664 8.578 31.222 1.00 28.87 ? 84 GLY A C 1 ATOM 650 O O . GLY A 1 84 ? -0.651 7.950 30.877 1.00 27.67 ? 84 GLY A O 1 ATOM 651 N N . TYR A 1 85 ? -1.915 9.836 30.873 1.00 29.29 ? 85 TYR A N 1 ATOM 652 C CA . TYR A 1 85 ? -0.946 10.733 30.266 1.00 30.30 ? 85 TYR A CA 1 ATOM 653 C C . TYR A 1 85 ? -1.513 12.165 30.279 1.00 31.56 ? 85 TYR A C 1 ATOM 654 O O . TYR A 1 85 ? -2.725 12.356 30.507 1.00 30.64 ? 85 TYR A O 1 ATOM 655 C CB . TYR A 1 85 ? -0.602 10.301 28.844 1.00 29.35 ? 85 TYR A CB 1 ATOM 656 C CG . TYR A 1 85 ? -1.728 10.499 27.852 1.00 29.50 ? 85 TYR A CG 1 ATOM 657 C CD1 . TYR A 1 85 ? -1.818 11.682 27.085 1.00 28.27 ? 85 TYR A CD1 1 ATOM 658 C CD2 . TYR A 1 85 ? -2.710 9.516 27.680 1.00 27.67 ? 85 TYR A CD2 1 ATOM 659 C CE1 . TYR A 1 85 ? -2.851 11.859 26.168 1.00 28.40 ? 85 TYR A CE1 1 ATOM 660 C CE2 . TYR A 1 85 ? -3.743 9.686 26.771 1.00 28.09 ? 85 TYR A CE2 1 ATOM 661 C CZ . TYR A 1 85 ? -3.808 10.857 26.016 1.00 28.50 ? 85 TYR A CZ 1 ATOM 662 O OH . TYR A 1 85 ? -4.838 11.023 25.126 1.00 28.62 ? 85 TYR A OH 1 ATOM 663 N N . LEU A 1 86 ? -0.639 13.142 29.999 1.00 33.19 ? 86 LEU A N 1 ATOM 664 C CA . LEU A 1 86 ? -0.958 14.570 30.136 1.00 34.66 ? 86 LEU A CA 1 ATOM 665 C C . LEU A 1 86 ? -0.923 15.258 28.788 1.00 35.44 ? 86 LEU A C 1 ATOM 666 O O . LEU A 1 86 ? -1.745 16.113 28.488 1.00 35.61 ? 86 LEU A O 1 ATOM 667 C CB . LEU A 1 86 ? 0.030 15.291 31.081 1.00 34.62 ? 86 LEU A CB 1 ATOM 668 C CG . LEU A 1 86 ? 0.201 15.034 32.594 1.00 35.46 ? 86 LEU A CG 1 ATOM 669 C CD1 . LEU A 1 86 ? 0.650 16.322 33.339 1.00 32.17 ? 86 LEU A CD1 1 ATOM 670 C CD2 . LEU A 1 86 ? -1.077 14.489 33.248 1.00 35.85 ? 86 LEU A CD2 1 ATOM 671 N N . ASP A 1 87 ? 0.046 14.899 27.974 1.00 36.80 ? 87 ASP A N 1 ATOM 672 C CA . ASP A 1 87 ? 0.250 15.638 26.754 1.00 38.50 ? 87 ASP A CA 1 ATOM 673 C C . ASP A 1 87 ? -0.574 15.100 25.605 1.00 39.27 ? 87 ASP A C 1 ATOM 674 O O . ASP A 1 87 ? -0.310 14.012 25.108 1.00 40.09 ? 87 ASP A O 1 ATOM 675 C CB . ASP A 1 87 ? 1.733 15.705 26.368 1.00 38.92 ? 87 ASP A CB 1 ATOM 676 C CG . ASP A 1 87 ? 2.006 16.821 25.407 1.00 40.75 ? 87 ASP A CG 1 ATOM 677 O OD1 . ASP A 1 87 ? 1.014 17.442 24.958 1.00 40.93 ? 87 ASP A OD1 1 ATOM 678 O OD2 . ASP A 1 87 ? 3.192 17.085 25.100 1.00 43.75 ? 87 ASP A OD2 1 ATOM 679 N N . GLU A 1 88 ? -1.556 15.885 25.168 1.00 40.01 ? 88 GLU A N 1 ATOM 680 C CA . GLU A 1 88 ? -2.384 15.510 24.041 1.00 40.54 ? 88 GLU A CA 1 ATOM 681 C C . GLU A 1 88 ? -1.684 15.703 22.714 1.00 41.44 ? 88 GLU A C 1 ATOM 682 O O . GLU A 1 88 ? -2.166 15.211 21.701 1.00 41.95 ? 88 GLU A O 1 ATOM 683 C CB . GLU A 1 88 ? -3.726 16.265 24.064 1.00 40.40 ? 88 GLU A CB 1 ATOM 684 C CG . GLU A 1 88 ? -4.610 15.935 25.294 1.00 39.35 ? 88 GLU A CG 1 ATOM 685 C CD . GLU A 1 88 ? -4.974 14.441 25.404 1.00 40.39 ? 88 GLU A CD 1 ATOM 686 O OE1 . GLU A 1 88 ? -4.924 13.709 24.366 1.00 38.35 ? 88 GLU A OE1 1 ATOM 687 O OE2 . GLU A 1 88 ? -5.311 14.000 26.535 1.00 38.88 ? 88 GLU A OE2 1 ATOM 688 N N . GLU A 1 89 ? -0.557 16.420 22.702 1.00 42.45 ? 89 GLU A N 1 ATOM 689 C CA . GLU A 1 89 ? 0.115 16.735 21.430 1.00 43.16 ? 89 GLU A CA 1 ATOM 690 C C . GLU A 1 89 ? 0.671 15.448 20.856 1.00 42.29 ? 89 GLU A C 1 ATOM 691 O O . GLU A 1 89 ? 1.088 14.572 21.606 1.00 42.25 ? 89 GLU A O 1 ATOM 692 C CB . GLU A 1 89 ? 1.245 17.778 21.588 1.00 43.91 ? 89 GLU A CB 1 ATOM 693 C CG . GLU A 1 89 ? 0.860 19.127 22.261 1.00 46.49 ? 89 GLU A CG 1 ATOM 694 C CD . GLU A 1 89 ? -0.364 19.797 21.647 1.00 49.45 ? 89 GLU A CD 1 ATOM 695 O OE1 . GLU A 1 89 ? -0.397 19.905 20.396 1.00 49.46 ? 89 GLU A OE1 1 ATOM 696 O OE2 . GLU A 1 89 ? -1.284 20.204 22.429 1.00 49.87 ? 89 GLU A OE2 1 ATOM 697 N N . GLY A 1 90 ? 0.641 15.335 19.533 1.00 41.58 ? 90 GLY A N 1 ATOM 698 C CA . GLY A 1 90 ? 1.176 14.172 18.833 1.00 40.94 ? 90 GLY A CA 1 ATOM 699 C C . GLY A 1 90 ? 0.523 12.836 19.153 1.00 40.24 ? 90 GLY A C 1 ATOM 700 O O . GLY A 1 90 ? 1.163 11.805 19.024 1.00 40.90 ? 90 GLY A O 1 ATOM 701 N N . VAL A 1 91 ? -0.740 12.830 19.567 1.00 38.78 ? 91 VAL A N 1 ATOM 702 C CA . VAL A 1 91 ? -1.377 11.559 19.874 1.00 37.45 ? 91 VAL A CA 1 ATOM 703 C C . VAL A 1 91 ? -2.370 11.138 18.820 1.00 36.04 ? 91 VAL A C 1 ATOM 704 O O . VAL A 1 91 ? -3.009 10.089 18.948 1.00 35.33 ? 91 VAL A O 1 ATOM 705 C CB . VAL A 1 91 ? -2.066 11.555 21.240 1.00 37.78 ? 91 VAL A CB 1 ATOM 706 C CG1 . VAL A 1 91 ? -1.099 12.046 22.289 1.00 37.97 ? 91 VAL A CG1 1 ATOM 707 C CG2 . VAL A 1 91 ? -3.398 12.374 21.213 1.00 37.30 ? 91 VAL A CG2 1 ATOM 708 N N . LEU A 1 92 ? -2.489 11.960 17.784 1.00 35.09 ? 92 LEU A N 1 ATOM 709 C CA . LEU A 1 92 ? -3.497 11.754 16.736 1.00 33.72 ? 92 LEU A CA 1 ATOM 710 C C . LEU A 1 92 ? -3.044 10.727 15.723 1.00 33.13 ? 92 LEU A C 1 ATOM 711 O O . LEU A 1 92 ? -1.848 10.569 15.457 1.00 32.52 ? 92 LEU A O 1 ATOM 712 C CB . LEU A 1 92 ? -3.881 13.064 16.052 1.00 33.01 ? 92 LEU A CB 1 ATOM 713 C CG . LEU A 1 92 ? -4.566 14.102 16.950 1.00 33.78 ? 92 LEU A CG 1 ATOM 714 C CD1 . LEU A 1 92 ? -5.138 15.264 16.123 1.00 30.38 ? 92 LEU A CD1 1 ATOM 715 C CD2 . LEU A 1 92 ? -5.659 13.503 17.902 1.00 34.93 ? 92 LEU A CD2 1 ATOM 716 N N . ASP A 1 93 ? -4.024 10.023 15.176 1.00 32.41 ? 93 ASP A N 1 ATOM 717 C CA . ASP A 1 93 ? -3.774 8.983 14.206 1.00 31.92 ? 93 ASP A CA 1 ATOM 718 C C . ASP A 1 93 ? -3.831 9.628 12.839 1.00 32.94 ? 93 ASP A C 1 ATOM 719 O O . ASP A 1 93 ? -4.863 10.161 12.438 1.00 32.19 ? 93 ASP A O 1 ATOM 720 C CB . ASP A 1 93 ? -4.833 7.890 14.351 1.00 31.05 ? 93 ASP A CB 1 ATOM 721 C CG . ASP A 1 93 ? -4.511 6.662 13.564 1.00 28.22 ? 93 ASP A CG 1 ATOM 722 O OD1 . ASP A 1 93 ? -3.711 6.776 12.596 1.00 24.80 ? 93 ASP A OD1 1 ATOM 723 O OD2 . ASP A 1 93 ? -5.055 5.589 13.930 1.00 21.37 ? 93 ASP A OD2 1 ATOM 724 N N . GLN A 1 94 ? -2.698 9.605 12.138 1.00 34.49 ? 94 GLN A N 1 ATOM 725 C CA . GLN A 1 94 ? -2.559 10.308 10.867 1.00 34.51 ? 94 GLN A CA 1 ATOM 726 C C . GLN A 1 94 ? -3.231 9.556 9.722 1.00 34.42 ? 94 GLN A C 1 ATOM 727 O O . GLN A 1 94 ? -3.547 10.154 8.695 1.00 34.84 ? 94 GLN A O 1 ATOM 728 C CB . GLN A 1 94 ? -1.080 10.621 10.551 1.00 35.58 ? 94 GLN A CB 1 ATOM 729 C CG . GLN A 1 94 ? -0.278 11.306 11.662 1.00 36.95 ? 94 GLN A CG 1 ATOM 730 C CD . GLN A 1 94 ? -0.836 12.680 12.156 1.00 42.25 ? 94 GLN A CD 1 ATOM 731 O OE1 . GLN A 1 94 ? -1.184 13.564 11.358 1.00 43.52 ? 94 GLN A OE1 1 ATOM 732 N NE2 . GLN A 1 94 ? -0.864 12.866 13.489 1.00 43.02 ? 94 GLN A NE2 1 ATOM 733 N N . ASN A 1 95 ? -3.490 8.268 9.928 1.00 34.11 ? 95 ASN A N 1 ATOM 734 C CA . ASN A 1 95 ? -4.129 7.444 8.909 1.00 33.00 ? 95 ASN A CA 1 ATOM 735 C C . ASN A 1 95 ? -5.590 7.088 9.201 1.00 31.11 ? 95 ASN A C 1 ATOM 736 O O . ASN A 1 95 ? -6.199 6.321 8.455 1.00 30.28 ? 95 ASN A O 1 ATOM 737 C CB . ASN A 1 95 ? -3.319 6.167 8.672 1.00 34.20 ? 95 ASN A CB 1 ATOM 738 C CG . ASN A 1 95 ? -2.382 6.282 7.486 1.00 39.34 ? 95 ASN A CG 1 ATOM 739 O OD1 . ASN A 1 95 ? -1.424 7.055 7.510 1.00 44.45 ? 95 ASN A OD1 1 ATOM 740 N ND2 . ASN A 1 95 ? -2.656 5.513 6.439 1.00 45.57 ? 95 ASN A ND2 1 ATOM 741 N N . ARG A 1 96 ? -6.154 7.636 10.275 1.00 29.09 ? 96 ARG A N 1 ATOM 742 C CA . ARG A 1 96 ? -7.553 7.348 10.604 1.00 27.70 ? 96 ARG A CA 1 ATOM 743 C C . ARG A 1 96 ? -8.411 8.609 10.889 1.00 26.63 ? 96 ARG A C 1 ATOM 744 O O . ARG A 1 96 ? -8.040 9.470 11.691 1.00 26.78 ? 96 ARG A O 1 ATOM 745 C CB . ARG A 1 96 ? -7.648 6.329 11.746 1.00 27.93 ? 96 ARG A CB 1 ATOM 746 C CG . ARG A 1 96 ? -6.894 4.993 11.518 1.00 28.04 ? 96 ARG A CG 1 ATOM 747 C CD . ARG A 1 96 ? -7.609 4.012 10.583 1.00 29.49 ? 96 ARG A CD 1 ATOM 748 N NE . ARG A 1 96 ? -6.819 2.796 10.370 1.00 30.12 ? 96 ARG A NE 1 ATOM 749 C CZ . ARG A 1 96 ? -5.731 2.713 9.594 1.00 33.46 ? 96 ARG A CZ 1 ATOM 750 N NH1 . ARG A 1 96 ? -5.274 3.784 8.937 1.00 32.29 ? 96 ARG A NH1 1 ATOM 751 N NH2 . ARG A 1 96 ? -5.079 1.558 9.479 1.00 30.90 ? 96 ARG A NH2 1 ATOM 752 N N . SER A 1 97 ? -9.553 8.713 10.230 1.00 24.90 ? 97 SER A N 1 ATOM 753 C CA . SER A 1 97 ? -10.471 9.782 10.507 1.00 24.54 ? 97 SER A CA 1 ATOM 754 C C . SER A 1 97 ? -11.111 9.530 11.872 1.00 24.51 ? 97 SER A C 1 ATOM 755 O O . SER A 1 97 ? -10.997 8.443 12.412 1.00 25.63 ? 97 SER A O 1 ATOM 756 C CB . SER A 1 97 ? -11.525 9.847 9.419 1.00 24.11 ? 97 SER A CB 1 ATOM 757 O OG . SER A 1 97 ? -12.327 8.662 9.395 1.00 25.44 ? 97 SER A OG 1 ATOM 758 N N . LEU A 1 98 ? -11.794 10.524 12.427 1.00 24.69 ? 98 LEU A N 1 ATOM 759 C CA . LEU A 1 98 ? -12.496 10.378 13.706 1.00 23.96 ? 98 LEU A CA 1 ATOM 760 C C . LEU A 1 98 ? -13.681 9.416 13.537 1.00 23.44 ? 98 LEU A C 1 ATOM 761 O O . LEU A 1 98 ? -14.229 8.897 14.499 1.00 22.76 ? 98 LEU A O 1 ATOM 762 C CB . LEU A 1 98 ? -12.945 11.758 14.211 1.00 23.85 ? 98 LEU A CB 1 ATOM 763 C CG . LEU A 1 98 ? -13.671 11.860 15.570 1.00 25.60 ? 98 LEU A CG 1 ATOM 764 C CD1 . LEU A 1 98 ? -12.844 11.290 16.755 1.00 25.88 ? 98 LEU A CD1 1 ATOM 765 C CD2 . LEU A 1 98 ? -14.123 13.285 15.844 1.00 23.08 ? 98 LEU A CD2 1 ATOM 766 N N . LEU A 1 99 ? -14.051 9.171 12.289 1.00 23.09 ? 99 LEU A N 1 ATOM 767 C CA . LEU A 1 99 ? -15.122 8.226 11.975 1.00 23.22 ? 99 LEU A CA 1 ATOM 768 C C . LEU A 1 99 ? -14.673 6.785 12.217 1.00 22.19 ? 99 LEU A C 1 ATOM 769 O O . LEU A 1 99 ? -15.487 5.937 12.469 1.00 23.19 ? 99 LEU A O 1 ATOM 770 C CB . LEU A 1 99 ? -15.647 8.425 10.543 1.00 22.43 ? 99 LEU A CB 1 ATOM 771 C CG . LEU A 1 99 ? -16.762 7.516 9.986 1.00 24.89 ? 99 LEU A CG 1 ATOM 772 C CD1 . LEU A 1 99 ? -18.131 7.573 10.766 1.00 25.83 ? 99 LEU A CD1 1 ATOM 773 C CD2 . LEU A 1 99 ? -17.021 7.826 8.542 1.00 23.69 ? 99 LEU A CD2 1 ATOM 774 N N . PHE A 1 100 ? -13.378 6.517 12.167 1.00 22.25 ? 100 PHE A N 1 ATOM 775 C CA . PHE A 1 100 ? -12.858 5.175 12.475 1.00 21.58 ? 100 PHE A CA 1 ATOM 776 C C . PHE A 1 100 ? -13.159 4.852 13.939 1.00 20.69 ? 100 PHE A C 1 ATOM 777 O O . PHE A 1 100 ? -13.659 3.777 14.248 1.00 21.00 ? 100 PHE A O 1 ATOM 778 C CB . PHE A 1 100 ? -11.366 5.121 12.167 1.00 22.08 ? 100 PHE A CB 1 ATOM 779 C CG . PHE A 1 100 ? -10.638 3.903 12.706 1.00 22.48 ? 100 PHE A CG 1 ATOM 780 C CD1 . PHE A 1 100 ? -10.787 2.652 12.105 1.00 23.01 ? 100 PHE A CD1 1 ATOM 781 C CD2 . PHE A 1 100 ? -9.743 4.034 13.762 1.00 20.59 ? 100 PHE A CD2 1 ATOM 782 C CE1 . PHE A 1 100 ? -10.072 1.538 12.573 1.00 25.38 ? 100 PHE A CE1 1 ATOM 783 C CE2 . PHE A 1 100 ? -9.001 2.937 14.247 1.00 22.63 ? 100 PHE A CE2 1 ATOM 784 C CZ . PHE A 1 100 ? -9.166 1.679 13.651 1.00 24.71 ? 100 PHE A CZ 1 ATOM 785 N N . MET A 1 101 ? -12.914 5.791 14.830 1.00 19.64 ? 101 MET A N 1 ATOM 786 C CA . MET A 1 101 ? -13.330 5.590 16.204 1.00 20.36 ? 101 MET A CA 1 ATOM 787 C C . MET A 1 101 ? -14.844 5.334 16.286 1.00 20.83 ? 101 MET A C 1 ATOM 788 O O . MET A 1 101 ? -15.281 4.310 16.837 1.00 21.50 ? 101 MET A O 1 ATOM 789 C CB . MET A 1 101 ? -12.895 6.777 17.075 1.00 20.06 ? 101 MET A CB 1 ATOM 790 C CG . MET A 1 101 ? -13.226 6.643 18.540 1.00 22.04 ? 101 MET A CG 1 ATOM 791 S SD . MET A 1 101 ? -14.903 7.137 19.027 1.00 23.33 ? 101 MET A SD 1 ATOM 792 C CE . MET A 1 101 ? -14.972 8.813 18.403 1.00 18.01 ? 101 MET A CE 1 ATOM 793 N N . GLN A 1 102 ? -15.630 6.238 15.709 1.00 20.41 ? 102 GLN A N 1 ATOM 794 C CA . GLN A 1 102 ? -17.070 6.259 15.917 1.00 19.95 ? 102 GLN A CA 1 ATOM 795 C C . GLN A 1 102 ? -17.765 5.044 15.317 1.00 19.84 ? 102 GLN A C 1 ATOM 796 O O . GLN A 1 102 ? -18.586 4.390 15.980 1.00 19.92 ? 102 GLN A O 1 ATOM 797 C CB . GLN A 1 102 ? -17.699 7.570 15.388 1.00 19.12 ? 102 GLN A CB 1 ATOM 798 C CG . GLN A 1 102 ? -19.136 7.767 15.846 1.00 18.45 ? 102 GLN A CG 1 ATOM 799 C CD . GLN A 1 102 ? -19.264 7.686 17.353 1.00 14.06 ? 102 GLN A CD 1 ATOM 800 O OE1 . GLN A 1 102 ? -18.871 8.619 18.057 1.00 15.66 ? 102 GLN A OE1 1 ATOM 801 N NE2 . GLN A 1 102 ? -19.745 6.551 17.861 1.00 10.00 ? 102 GLN A NE2 1 ATOM 802 N N . TRP A 1 103 ? -17.430 4.706 14.081 1.00 19.53 ? 103 TRP A N 1 ATOM 803 C CA . TRP A 1 103 ? -17.907 3.424 13.552 1.00 18.69 ? 103 TRP A CA 1 ATOM 804 C C . TRP A 1 103 ? -17.644 2.269 14.558 1.00 18.95 ? 103 TRP A C 1 ATOM 805 O O . TRP A 1 103 ? -18.533 1.484 14.862 1.00 19.93 ? 103 TRP A O 1 ATOM 806 C CB . TRP A 1 103 ? -17.301 3.090 12.197 1.00 17.79 ? 103 TRP A CB 1 ATOM 807 C CG . TRP A 1 103 ? -18.161 2.086 11.544 1.00 16.71 ? 103 TRP A CG 1 ATOM 808 C CD1 . TRP A 1 103 ? -17.859 0.797 11.274 1.00 16.97 ? 103 TRP A CD1 1 ATOM 809 C CD2 . TRP A 1 103 ? -19.519 2.282 11.125 1.00 15.71 ? 103 TRP A CD2 1 ATOM 810 N NE1 . TRP A 1 103 ? -18.949 0.157 10.688 1.00 16.44 ? 103 TRP A NE1 1 ATOM 811 C CE2 . TRP A 1 103 ? -19.977 1.057 10.598 1.00 17.52 ? 103 TRP A CE2 1 ATOM 812 C CE3 . TRP A 1 103 ? -20.384 3.387 11.128 1.00 16.39 ? 103 TRP A CE3 1 ATOM 813 C CZ2 . TRP A 1 103 ? -21.265 0.903 10.086 1.00 21.13 ? 103 TRP A CZ2 1 ATOM 814 C CZ3 . TRP A 1 103 ? -21.663 3.238 10.636 1.00 20.07 ? 103 TRP A CZ3 1 ATOM 815 C CH2 . TRP A 1 103 ? -22.092 2.007 10.115 1.00 22.57 ? 103 TRP A CH2 1 ATOM 816 N N . GLY A 1 104 ? -16.424 2.159 15.065 1.00 18.41 ? 104 GLY A N 1 ATOM 817 C CA . GLY A 1 104 ? -16.132 1.153 16.081 1.00 18.76 ? 104 GLY A CA 1 ATOM 818 C C . GLY A 1 104 ? -17.160 1.067 17.205 1.00 18.77 ? 104 GLY A C 1 ATOM 819 O O . GLY A 1 104 ? -17.569 -0.017 17.569 1.00 19.31 ? 104 GLY A O 1 ATOM 820 N N . GLN A 1 105 ? -17.587 2.201 17.751 1.00 19.30 ? 105 GLN A N 1 ATOM 821 C CA . GLN A 1 105 ? -18.567 2.186 18.844 1.00 19.44 ? 105 GLN A CA 1 ATOM 822 C C . GLN A 1 105 ? -19.956 1.800 18.360 1.00 19.86 ? 105 GLN A C 1 ATOM 823 O O . GLN A 1 105 ? -20.683 1.113 19.072 1.00 19.08 ? 105 GLN A O 1 ATOM 824 C CB . GLN A 1 105 ? -18.590 3.537 19.549 1.00 19.23 ? 105 GLN A CB 1 ATOM 825 C CG . GLN A 1 105 ? -19.318 3.538 20.874 1.00 17.45 ? 105 GLN A CG 1 ATOM 826 C CD . GLN A 1 105 ? -19.384 4.916 21.448 1.00 15.99 ? 105 GLN A CD 1 ATOM 827 O OE1 . GLN A 1 105 ? -19.278 5.894 20.722 1.00 17.26 ? 105 GLN A OE1 1 ATOM 828 N NE2 . GLN A 1 105 ? -19.532 5.014 22.753 1.00 15.23 ? 105 GLN A NE2 1 ATOM 829 N N . ILE A 1 106 ? -20.296 2.211 17.126 1.00 21.54 ? 106 ILE A N 1 ATOM 830 C CA . ILE A 1 106 ? -21.546 1.809 16.468 1.00 22.04 ? 106 ILE A CA 1 ATOM 831 C C . ILE A 1 106 ? -21.637 0.301 16.485 1.00 22.53 ? 106 ILE A C 1 ATOM 832 O O . ILE A 1 106 ? -22.575 -0.274 17.071 1.00 23.15 ? 106 ILE A O 1 ATOM 833 C CB . ILE A 1 106 ? -21.633 2.245 14.965 1.00 22.66 ? 106 ILE A CB 1 ATOM 834 C CG1 . ILE A 1 106 ? -21.882 3.739 14.811 1.00 21.65 ? 106 ILE A CG1 1 ATOM 835 C CG2 . ILE A 1 106 ? -22.778 1.465 14.231 1.00 23.72 ? 106 ILE A CG2 1 ATOM 836 C CD1 . ILE A 1 106 ? -23.001 4.279 15.702 1.00 24.88 ? 106 ILE A CD1 1 ATOM 837 N N . VAL A 1 107 ? -20.644 -0.334 15.872 1.00 22.42 ? 107 VAL A N 1 ATOM 838 C CA . VAL A 1 107 ? -20.614 -1.787 15.724 1.00 22.47 ? 107 VAL A CA 1 ATOM 839 C C . VAL A 1 107 ? -20.596 -2.503 17.056 1.00 23.63 ? 107 VAL A C 1 ATOM 840 O O . VAL A 1 107 ? -21.310 -3.507 17.260 1.00 24.26 ? 107 VAL A O 1 ATOM 841 C CB . VAL A 1 107 ? -19.402 -2.246 14.910 1.00 22.35 ? 107 VAL A CB 1 ATOM 842 C CG1 . VAL A 1 107 ? -19.380 -3.784 14.835 1.00 22.94 ? 107 VAL A CG1 1 ATOM 843 C CG2 . VAL A 1 107 ? -19.470 -1.649 13.520 1.00 20.73 ? 107 VAL A CG2 1 ATOM 844 N N . ASP A 1 108 ? -19.807 -1.986 17.991 1.00 24.30 ? 108 ASP A N 1 ATOM 845 C CA . ASP A 1 108 ? -19.733 -2.565 19.329 1.00 23.97 ? 108 ASP A CA 1 ATOM 846 C C . ASP A 1 108 ? -21.094 -2.551 20.025 1.00 24.21 ? 108 ASP A C 1 ATOM 847 O O . ASP A 1 108 ? -21.437 -3.478 20.758 1.00 24.85 ? 108 ASP A O 1 ATOM 848 C CB . ASP A 1 108 ? -18.700 -1.821 20.179 1.00 23.59 ? 108 ASP A CB 1 ATOM 849 C CG . ASP A 1 108 ? -18.321 -2.582 21.434 1.00 23.05 ? 108 ASP A CG 1 ATOM 850 O OD1 . ASP A 1 108 ? -19.044 -2.462 22.445 1.00 24.79 ? 108 ASP A OD1 1 ATOM 851 O OD2 . ASP A 1 108 ? -17.300 -3.301 21.409 1.00 21.08 ? 108 ASP A OD2 1 ATOM 852 N N . HIS A 1 109 ? -21.863 -1.492 19.790 1.00 24.39 ? 109 HIS A N 1 ATOM 853 C CA . HIS A 1 109 ? -23.184 -1.336 20.398 1.00 24.25 ? 109 HIS A CA 1 ATOM 854 C C . HIS A 1 109 ? -24.259 -2.182 19.715 1.00 24.70 ? 109 HIS A C 1 ATOM 855 O O . HIS A 1 109 ? -25.294 -2.499 20.317 1.00 24.47 ? 109 HIS A O 1 ATOM 856 C CB . HIS A 1 109 ? -23.576 0.132 20.392 1.00 23.49 ? 109 HIS A CB 1 ATOM 857 C CG . HIS A 1 109 ? -23.017 0.892 21.549 1.00 24.76 ? 109 HIS A CG 1 ATOM 858 N ND1 . HIS A 1 109 ? -23.327 2.211 21.791 1.00 21.14 ? 109 HIS A ND1 1 ATOM 859 C CD2 . HIS A 1 109 ? -22.210 0.498 22.567 1.00 22.67 ? 109 HIS A CD2 1 ATOM 860 C CE1 . HIS A 1 109 ? -22.716 2.607 22.891 1.00 20.09 ? 109 HIS A CE1 1 ATOM 861 N NE2 . HIS A 1 109 ? -22.043 1.583 23.389 1.00 22.15 ? 109 HIS A NE2 1 ATOM 862 N N . ASP A 1 110 ? -23.988 -2.569 18.478 1.00 24.67 ? 110 ASP A N 1 ATOM 863 C CA . ASP A 1 110 ? -24.877 -3.459 17.758 1.00 25.54 ? 110 ASP A CA 1 ATOM 864 C C . ASP A 1 110 ? -24.661 -4.867 18.288 1.00 25.20 ? 110 ASP A C 1 ATOM 865 O O . ASP A 1 110 ? -25.565 -5.709 18.240 1.00 25.35 ? 110 ASP A O 1 ATOM 866 C CB . ASP A 1 110 ? -24.585 -3.392 16.249 1.00 25.17 ? 110 ASP A CB 1 ATOM 867 C CG . ASP A 1 110 ? -25.627 -4.100 15.392 1.00 26.05 ? 110 ASP A CG 1 ATOM 868 O OD1 . ASP A 1 110 ? -25.982 -5.264 15.639 1.00 27.72 ? 110 ASP A OD1 1 ATOM 869 O OD2 . ASP A 1 110 ? -26.060 -3.498 14.398 1.00 30.93 ? 110 ASP A OD2 1 ATOM 870 N N . LEU A 1 111 ? -23.470 -5.110 18.808 1.00 25.05 ? 111 LEU A N 1 ATOM 871 C CA . LEU A 1 111 ? -23.034 -6.486 19.109 1.00 25.21 ? 111 LEU A CA 1 ATOM 872 C C . LEU A 1 111 ? -23.250 -6.915 20.515 1.00 25.69 ? 111 LEU A C 1 ATOM 873 O O . LEU A 1 111 ? -23.652 -8.030 20.725 1.00 26.63 ? 111 LEU A O 1 ATOM 874 C CB . LEU A 1 111 ? -21.556 -6.719 18.721 1.00 24.29 ? 111 LEU A CB 1 ATOM 875 C CG . LEU A 1 111 ? -21.397 -6.703 17.210 1.00 23.06 ? 111 LEU A CG 1 ATOM 876 C CD1 . LEU A 1 111 ? -20.012 -7.129 16.765 1.00 24.44 ? 111 LEU A CD1 1 ATOM 877 C CD2 . LEU A 1 111 ? -22.504 -7.575 16.574 1.00 19.34 ? 111 LEU A CD2 1 ATOM 878 N N . ASP A 1 112 ? -22.985 -6.040 21.481 1.00 26.82 ? 112 ASP A N 1 ATOM 879 C CA . ASP A 1 112 ? -23.019 -6.447 22.884 1.00 28.06 ? 112 ASP A CA 1 ATOM 880 C C . ASP A 1 112 ? -23.407 -5.337 23.855 1.00 29.93 ? 112 ASP A C 1 ATOM 881 O O . ASP A 1 112 ? -23.148 -4.142 23.613 1.00 30.72 ? 112 ASP A O 1 ATOM 882 C CB . ASP A 1 112 ? -21.689 -7.114 23.316 1.00 27.46 ? 112 ASP A CB 1 ATOM 883 C CG . ASP A 1 112 ? -20.437 -6.404 22.771 1.00 26.97 ? 112 ASP A CG 1 ATOM 884 O OD1 . ASP A 1 112 ? -20.099 -6.563 21.592 1.00 26.72 ? 112 ASP A OD1 1 ATOM 885 O OD2 . ASP A 1 112 ? -19.756 -5.707 23.528 1.00 27.46 ? 112 ASP A OD2 1 ATOM 886 N N . PHE A 1 113 ? -24.031 -5.731 24.957 1.00 31.01 ? 113 PHE A N 1 ATOM 887 C CA . PHE A 1 113 ? -24.275 -4.826 26.056 1.00 32.31 ? 113 PHE A CA 1 ATOM 888 C C . PHE A 1 113 ? -24.121 -5.970 27.026 1.00 33.53 ? 113 PHE A C 1 ATOM 889 O O . PHE A 1 113 ? -24.437 -7.096 26.682 1.00 34.27 ? 113 PHE A O 1 ATOM 890 C CB . PHE A 1 113 ? -25.486 -3.961 25.727 1.00 32.69 ? 113 PHE A CB 1 ATOM 891 C CG . PHE A 1 113 ? -25.870 -2.977 26.798 1.00 33.51 ? 113 PHE A CG 1 ATOM 892 C CD1 . PHE A 1 113 ? -24.922 -2.447 27.673 1.00 34.48 ? 113 PHE A CD1 1 ATOM 893 C CD2 . PHE A 1 113 ? -27.197 -2.532 26.885 1.00 34.88 ? 113 PHE A CD2 1 ATOM 894 C CE1 . PHE A 1 113 ? -25.305 -1.542 28.665 1.00 36.03 ? 113 PHE A CE1 1 ATOM 895 C CE2 . PHE A 1 113 ? -27.592 -1.602 27.845 1.00 35.28 ? 113 PHE A CE2 1 ATOM 896 C CZ . PHE A 1 113 ? -26.645 -1.104 28.747 1.00 36.39 ? 113 PHE A CZ 1 ATOM 897 N N . ALA A 1 114 ? -23.595 -5.703 28.221 1.00 35.22 ? 114 ALA A N 1 ATOM 898 C CA . ALA A 1 114 ? -23.817 -6.413 29.497 1.00 36.93 ? 114 ALA A CA 1 ATOM 899 C C . ALA A 1 114 ? -24.121 -5.383 30.583 1.00 38.56 ? 114 ALA A C 1 ATOM 900 O O . ALA A 1 114 ? -23.216 -4.934 31.298 1.00 37.42 ? 114 ALA A O 1 ATOM 901 C CB . ALA A 1 114 ? -22.631 -7.303 29.875 1.00 35.90 ? 114 ALA A CB 1 ATOM 902 N N . PRO A 1 115 ? -25.413 -5.008 30.704 1.00 41.35 ? 115 PRO A N 1 ATOM 903 C CA . PRO A 1 115 ? -25.834 -3.892 31.557 1.00 43.45 ? 115 PRO A CA 1 ATOM 904 C C . PRO A 1 115 ? -25.846 -4.273 33.025 1.00 45.36 ? 115 PRO A C 1 ATOM 905 O O . PRO A 1 115 ? -26.029 -5.449 33.375 1.00 45.05 ? 115 PRO A O 1 ATOM 906 C CB . PRO A 1 115 ? -27.270 -3.591 31.081 1.00 43.73 ? 115 PRO A CB 1 ATOM 907 C CG . PRO A 1 115 ? -27.784 -4.921 30.606 1.00 43.76 ? 115 PRO A CG 1 ATOM 908 C CD . PRO A 1 115 ? -26.571 -5.777 30.199 1.00 41.50 ? 115 PRO A CD 1 ATOM 909 N N . GLU A 1 116 ? -25.652 -3.267 33.870 1.00 48.03 ? 116 GLU A N 1 ATOM 910 C CA . GLU A 1 116 ? -25.679 -3.450 35.310 1.00 50.90 ? 116 GLU A CA 1 ATOM 911 C C . GLU A 1 116 ? -26.969 -4.109 35.795 1.00 52.83 ? 116 GLU A C 1 ATOM 912 O O . GLU A 1 116 ? -28.022 -3.969 35.177 1.00 52.56 ? 116 GLU A O 1 ATOM 913 C CB . GLU A 1 116 ? -25.425 -2.109 35.993 1.00 51.05 ? 116 GLU A CB 1 ATOM 914 C CG . GLU A 1 116 ? -24.016 -1.567 35.713 1.00 51.71 ? 116 GLU A CG 1 ATOM 915 C CD . GLU A 1 116 ? -23.780 -0.190 36.293 1.00 54.08 ? 116 GLU A CD 1 ATOM 916 O OE1 . GLU A 1 116 ? -24.635 0.272 37.085 1.00 55.46 ? 116 GLU A OE1 1 ATOM 917 O OE2 . GLU A 1 116 ? -22.740 0.433 35.961 1.00 54.01 ? 116 GLU A OE2 1 ATOM 918 N N . THR A 1 117 ? -26.849 -4.878 36.875 1.00 55.99 ? 117 THR A N 1 ATOM 919 C CA . THR A 1 117 ? -27.969 -5.582 37.518 1.00 59.12 ? 117 THR A CA 1 ATOM 920 C C . THR A 1 117 ? -29.188 -4.680 37.806 1.00 61.47 ? 117 THR A C 1 ATOM 921 O O . THR A 1 117 ? -29.035 -3.503 38.175 1.00 61.32 ? 117 THR A O 1 ATOM 922 C CB . THR A 1 117 ? -27.519 -6.166 38.859 1.00 59.08 ? 117 THR A CB 1 ATOM 923 O OG1 . THR A 1 117 ? -26.681 -5.210 39.521 1.00 59.93 ? 117 THR A OG1 1 ATOM 924 C CG2 . THR A 1 117 ? -26.738 -7.458 38.667 1.00 59.18 ? 117 THR A CG2 1 ATOM 925 N N . GLU A 1 118 ? -30.387 -5.244 37.640 1.00 64.18 ? 118 GLU A N 1 ATOM 926 C CA . GLU A 1 118 ? -31.636 -4.526 37.923 1.00 67.26 ? 118 GLU A CA 1 ATOM 927 C C . GLU A 1 118 ? -32.536 -4.689 39.173 1.00 68.81 ? 118 GLU A C 1 ATOM 928 O O . GLU A 1 118 ? -33.778 -4.570 39.102 1.00 68.68 ? 118 GLU A O 1 ATOM 929 C CB . GLU A 1 118 ? -32.495 -4.379 36.651 1.00 67.60 ? 118 GLU A CB 1 ATOM 930 C CG . GLU A 1 118 ? -32.063 -3.224 35.738 1.00 69.37 ? 118 GLU A CG 1 ATOM 931 C CD . GLU A 1 118 ? -32.219 -1.856 36.406 1.00 71.55 ? 118 GLU A CD 1 ATOM 932 O OE1 . GLU A 1 118 ? -33.375 -1.392 36.572 1.00 72.06 ? 118 GLU A OE1 1 ATOM 933 O OE2 . GLU A 1 118 ? -31.183 -1.249 36.764 1.00 71.94 ? 118 GLU A OE2 1 ATOM 934 N N . LEU A 1 119 ? -31.872 -4.973 40.299 1.00 70.79 ? 119 LEU A N 1 ATOM 935 C CA . LEU A 1 119 ? -32.511 -5.310 41.577 1.00 72.69 ? 119 LEU A CA 1 ATOM 936 C C . LEU A 1 119 ? -32.462 -4.086 42.531 1.00 73.95 ? 119 LEU A C 1 ATOM 937 O O . LEU A 1 119 ? -32.341 -4.228 43.760 1.00 73.62 ? 119 LEU A O 1 ATOM 938 C CB . LEU A 1 119 ? -31.836 -6.556 42.190 1.00 72.74 ? 119 LEU A CB 1 ATOM 939 C CG . LEU A 1 119 ? -32.311 -7.200 43.509 1.00 73.12 ? 119 LEU A CG 1 ATOM 940 C CD1 . LEU A 1 119 ? -33.838 -7.389 43.579 1.00 73.19 ? 119 LEU A CD1 1 ATOM 941 C CD2 . LEU A 1 119 ? -31.573 -8.520 43.771 1.00 72.50 ? 119 LEU A CD2 1 ATOM 942 N N . GLY A 1 120 ? -32.256 -2.929 41.888 1.00 75.45 ? 120 GLY A N 1 ATOM 943 C CA . GLY A 1 120 ? -32.162 -1.630 42.528 1.00 77.35 ? 120 GLY A CA 1 ATOM 944 C C . GLY A 1 120 ? -32.126 -0.320 41.722 1.00 78.77 ? 120 GLY A C 1 ATOM 945 O O . GLY A 1 120 ? -31.091 0.339 41.644 1.00 78.85 ? 120 GLY A O 1 ATOM 946 N N . SER A 1 121 ? -33.239 0.094 41.151 1.00 80.11 ? 121 SER A N 1 ATOM 947 C CA . SER A 1 121 ? -33.426 1.455 40.560 1.00 81.11 ? 121 SER A CA 1 ATOM 948 C C . SER A 1 121 ? -33.890 2.667 41.408 1.00 81.82 ? 121 SER A C 1 ATOM 949 O O . SER A 1 121 ? -33.750 3.822 40.982 1.00 81.65 ? 121 SER A O 1 ATOM 950 C CB . SER A 1 121 ? -34.579 0.930 39.679 1.00 81.05 ? 121 SER A CB 1 ATOM 951 O OG . SER A 1 121 ? -34.173 -0.180 38.893 1.00 80.50 ? 121 SER A OG 1 ATOM 952 N N . ASN A 1 122 ? -34.457 2.386 42.574 1.00 82.75 ? 122 ASN A N 1 ATOM 953 C CA . ASN A 1 122 ? -34.880 3.421 43.501 1.00 83.46 ? 122 ASN A CA 1 ATOM 954 C C . ASN A 1 122 ? -34.875 2.980 44.965 1.00 84.02 ? 122 ASN A C 1 ATOM 955 O O . ASN A 1 122 ? -35.906 2.895 45.582 1.00 84.07 ? 122 ASN A O 1 ATOM 956 C CB . ASN A 1 122 ? -36.250 3.960 43.120 1.00 83.25 ? 122 ASN A CB 1 ATOM 957 C CG . ASN A 1 122 ? -36.689 5.055 44.024 1.00 82.83 ? 122 ASN A CG 1 ATOM 958 O OD1 . ASN A 1 122 ? -37.091 4.811 45.144 1.00 82.26 ? 122 ASN A OD1 1 ATOM 959 N ND2 . ASN A 1 122 ? -36.600 6.275 43.554 1.00 81.95 ? 122 ASN A ND2 1 ATOM 960 N N . GLU A 1 123 ? -33.699 2.731 45.508 1.00 84.69 ? 123 GLU A N 1 ATOM 961 C CA . GLU A 1 123 ? -33.495 2.276 46.890 1.00 85.18 ? 123 GLU A CA 1 ATOM 962 C C . GLU A 1 123 ? -32.437 3.209 47.506 1.00 85.18 ? 123 GLU A C 1 ATOM 963 O O . GLU A 1 123 ? -31.864 4.053 46.807 1.00 85.20 ? 123 GLU A O 1 ATOM 964 C CB . GLU A 1 123 ? -33.019 0.804 46.888 1.00 85.39 ? 123 GLU A CB 1 ATOM 965 C CG . GLU A 1 123 ? -32.949 0.085 48.259 1.00 85.70 ? 123 GLU A CG 1 ATOM 966 C CD . GLU A 1 123 ? -34.292 -0.440 48.761 1.00 85.99 ? 123 GLU A CD 1 ATOM 967 O OE1 . GLU A 1 123 ? -35.173 0.385 49.088 1.00 85.52 ? 123 GLU A OE1 1 ATOM 968 O OE2 . GLU A 1 123 ? -34.455 -1.680 48.857 1.00 85.58 ? 123 GLU A OE2 1 ATOM 969 N N . HIS A 1 124 ? -32.210 3.085 48.814 1.00 85.23 ? 124 HIS A N 1 ATOM 970 C CA . HIS A 1 124 ? -30.978 3.521 49.476 1.00 85.15 ? 124 HIS A CA 1 ATOM 971 C C . HIS A 1 124 ? -29.738 2.888 48.858 1.00 84.74 ? 124 HIS A C 1 ATOM 972 O O . HIS A 1 124 ? -28.795 3.589 48.474 1.00 84.62 ? 124 HIS A O 1 ATOM 973 C CB . HIS A 1 124 ? -30.979 3.297 50.997 1.00 85.20 ? 124 HIS A CB 1 ATOM 974 C CG . HIS A 1 124 ? -31.580 4.425 51.780 1.00 86.22 ? 124 HIS A CG 1 ATOM 975 N ND1 . HIS A 1 124 ? -31.246 5.745 51.562 1.00 87.46 ? 124 HIS A ND1 1 ATOM 976 C CD2 . HIS A 1 124 ? -32.484 4.428 52.790 1.00 86.90 ? 124 HIS A CD2 1 ATOM 977 C CE1 . HIS A 1 124 ? -31.926 6.514 52.397 1.00 87.43 ? 124 HIS A CE1 1 ATOM 978 N NE2 . HIS A 1 124 ? -32.684 5.739 53.152 1.00 87.30 ? 124 HIS A NE2 1 ATOM 979 N N . SER A 1 125 ? -29.785 1.556 48.762 1.00 84.26 ? 125 SER A N 1 ATOM 980 C CA . SER A 1 125 ? -28.721 0.689 48.237 1.00 83.62 ? 125 SER A CA 1 ATOM 981 C C . SER A 1 125 ? -27.855 1.311 47.139 1.00 83.06 ? 125 SER A C 1 ATOM 982 O O . SER A 1 125 ? -26.625 1.224 47.199 1.00 83.08 ? 125 SER A O 1 ATOM 983 C CB . SER A 1 125 ? -29.325 -0.629 47.736 1.00 83.85 ? 125 SER A CB 1 ATOM 984 O OG . SER A 1 125 ? -30.241 -1.178 48.677 1.00 84.12 ? 125 SER A OG 1 ATOM 985 N N . LYS A 1 126 ? -28.503 1.925 46.148 1.00 82.12 ? 126 LYS A N 1 ATOM 986 C CA . LYS A 1 126 ? -27.810 2.623 45.070 1.00 81.36 ? 126 LYS A CA 1 ATOM 987 C C . LYS A 1 126 ? -26.826 3.659 45.629 1.00 80.61 ? 126 LYS A C 1 ATOM 988 O O . LYS A 1 126 ? -25.607 3.474 45.561 1.00 80.66 ? 126 LYS A O 1 ATOM 989 C CB . LYS A 1 126 ? -28.809 3.310 44.136 1.00 81.58 ? 126 LYS A CB 1 ATOM 990 C CG . LYS A 1 126 ? -30.113 2.552 43.906 1.00 82.33 ? 126 LYS A CG 1 ATOM 991 C CD . LYS A 1 126 ? -30.985 3.263 42.882 1.00 82.68 ? 126 LYS A CD 1 ATOM 992 C CE . LYS A 1 126 ? -31.405 4.656 43.348 1.00 83.62 ? 126 LYS A CE 1 ATOM 993 N NZ . LYS A 1 126 ? -32.242 5.369 42.332 1.00 83.49 ? 126 LYS A NZ 1 ATOM 994 N N . THR A 1 127 ? -27.365 4.734 46.200 1.00 79.56 ? 127 THR A N 1 ATOM 995 C CA . THR A 1 127 ? -26.555 5.801 46.785 1.00 78.32 ? 127 THR A CA 1 ATOM 996 C C . THR A 1 127 ? -25.629 5.323 47.899 1.00 77.34 ? 127 THR A C 1 ATOM 997 O O . THR A 1 127 ? -24.742 6.061 48.312 1.00 77.27 ? 127 THR A O 1 ATOM 998 C CB . THR A 1 127 ? -27.428 6.962 47.309 1.00 78.58 ? 127 THR A CB 1 ATOM 999 O OG1 . THR A 1 127 ? -28.711 6.460 47.713 1.00 78.72 ? 127 THR A OG1 1 ATOM 1000 C CG2 . THR A 1 127 ? -27.615 8.022 46.222 1.00 78.90 ? 127 THR A CG2 1 ATOM 1001 N N . GLN A 1 128 ? -25.832 4.091 48.371 1.00 76.00 ? 128 GLN A N 1 ATOM 1002 C CA . GLN A 1 128 ? -24.968 3.492 49.392 1.00 74.68 ? 128 GLN A CA 1 ATOM 1003 C C . GLN A 1 128 ? -23.582 3.168 48.832 1.00 73.50 ? 128 GLN A C 1 ATOM 1004 O O . GLN A 1 128 ? -22.569 3.220 49.545 1.00 73.33 ? 128 GLN A O 1 ATOM 1005 C CB . GLN A 1 128 ? -25.607 2.226 49.955 1.00 74.85 ? 128 GLN A CB 1 ATOM 1006 C CG . GLN A 1 128 ? -24.902 1.677 51.195 1.00 75.82 ? 128 GLN A CG 1 ATOM 1007 C CD . GLN A 1 128 ? -25.712 0.617 51.925 1.00 76.91 ? 128 GLN A CD 1 ATOM 1008 O OE1 . GLN A 1 128 ? -25.781 0.619 53.159 1.00 76.94 ? 128 GLN A OE1 1 ATOM 1009 N NE2 . GLN A 1 128 ? -26.327 -0.299 51.168 1.00 76.96 ? 128 GLN A NE2 1 ATOM 1010 N N . CYS A 1 129 ? -23.553 2.827 47.550 1.00 71.84 ? 129 CYS A N 1 ATOM 1011 C CA . CYS A 1 129 ? -22.305 2.543 46.860 1.00 70.18 ? 129 CYS A CA 1 ATOM 1012 C C . CYS A 1 129 ? -21.592 3.864 46.514 1.00 69.95 ? 129 CYS A C 1 ATOM 1013 O O . CYS A 1 129 ? -20.371 3.962 46.708 1.00 70.07 ? 129 CYS A O 1 ATOM 1014 C CB . CYS A 1 129 ? -22.572 1.675 45.617 1.00 69.61 ? 129 CYS A CB 1 ATOM 1015 S SG . CYS A 1 129 ? -21.255 0.540 45.035 1.00 65.08 ? 129 CYS A SG 1 ATOM 1016 N N . GLU A 1 130 ? -22.340 4.874 46.037 1.00 69.10 ? 130 GLU A N 1 ATOM 1017 C CA . GLU A 1 130 ? -21.735 6.202 45.764 1.00 68.33 ? 130 GLU A CA 1 ATOM 1018 C C . GLU A 1 130 ? -21.331 6.908 47.054 1.00 67.37 ? 130 GLU A C 1 ATOM 1019 O O . GLU A 1 130 ? -20.249 7.494 47.130 1.00 67.13 ? 130 GLU A O 1 ATOM 1020 C CB . GLU A 1 130 ? -22.603 7.127 44.868 1.00 68.38 ? 130 GLU A CB 1 ATOM 1021 C CG . GLU A 1 130 ? -21.870 8.464 44.475 1.00 68.60 ? 130 GLU A CG 1 ATOM 1022 C CD . GLU A 1 130 ? -22.516 9.289 43.328 1.00 69.22 ? 130 GLU A CD 1 ATOM 1023 O OE1 . GLU A 1 130 ? -23.698 9.041 42.968 1.00 69.33 ? 130 GLU A OE1 1 ATOM 1024 O OE2 . GLU A 1 130 ? -21.829 10.208 42.797 1.00 66.55 ? 130 GLU A OE2 1 ATOM 1025 N N . GLU A 1 131 ? -22.194 6.830 48.067 1.00 66.51 ? 131 GLU A N 1 ATOM 1026 C CA . GLU A 1 131 ? -21.968 7.539 49.337 1.00 65.34 ? 131 GLU A CA 1 ATOM 1027 C C . GLU A 1 131 ? -20.986 6.870 50.306 1.00 64.54 ? 131 GLU A C 1 ATOM 1028 O O . GLU A 1 131 ? -20.161 7.554 50.916 1.00 64.78 ? 131 GLU A O 1 ATOM 1029 C CB . GLU A 1 131 ? -23.287 7.804 50.061 1.00 65.28 ? 131 GLU A CB 1 ATOM 1030 C CG . GLU A 1 131 ? -23.899 9.166 49.795 1.00 65.00 ? 131 GLU A CG 1 ATOM 1031 C CD . GLU A 1 131 ? -24.741 9.663 50.971 1.00 64.35 ? 131 GLU A CD 1 ATOM 1032 O OE1 . GLU A 1 131 ? -25.604 8.905 51.462 1.00 61.70 ? 131 GLU A OE1 1 ATOM 1033 O OE2 . GLU A 1 131 ? -24.531 10.820 51.398 1.00 64.63 ? 131 GLU A OE2 1 ATOM 1034 N N . TYR A 1 132 ? -21.065 5.549 50.454 1.00 63.07 ? 132 TYR A N 1 ATOM 1035 C CA . TYR A 1 132 ? -20.366 4.911 51.568 1.00 61.90 ? 132 TYR A CA 1 ATOM 1036 C C . TYR A 1 132 ? -19.195 4.005 51.181 1.00 60.45 ? 132 TYR A C 1 ATOM 1037 O O . TYR A 1 132 ? -18.418 3.614 52.053 1.00 60.90 ? 132 TYR A O 1 ATOM 1038 C CB . TYR A 1 132 ? -21.356 4.188 52.505 1.00 62.53 ? 132 TYR A CB 1 ATOM 1039 C CG . TYR A 1 132 ? -22.435 5.084 53.107 1.00 64.01 ? 132 TYR A CG 1 ATOM 1040 C CD1 . TYR A 1 132 ? -23.708 5.173 52.530 1.00 65.56 ? 132 TYR A CD1 1 ATOM 1041 C CD2 . TYR A 1 132 ? -22.177 5.843 54.253 1.00 66.00 ? 132 TYR A CD2 1 ATOM 1042 C CE1 . TYR A 1 132 ? -24.701 6.001 53.084 1.00 67.71 ? 132 TYR A CE1 1 ATOM 1043 C CE2 . TYR A 1 132 ? -23.156 6.673 54.815 1.00 67.63 ? 132 TYR A CE2 1 ATOM 1044 C CZ . TYR A 1 132 ? -24.414 6.747 54.230 1.00 67.93 ? 132 TYR A CZ 1 ATOM 1045 O OH . TYR A 1 132 ? -25.365 7.568 54.793 1.00 68.37 ? 132 TYR A OH 1 ATOM 1046 N N . CYS A 1 133 ? -19.054 3.699 49.890 1.00 58.07 ? 133 CYS A N 1 ATOM 1047 C CA . CYS A 1 133 ? -17.950 2.862 49.382 1.00 55.49 ? 133 CYS A CA 1 ATOM 1048 C C . CYS A 1 133 ? -17.899 1.502 50.074 1.00 54.94 ? 133 CYS A C 1 ATOM 1049 O O . CYS A 1 133 ? -16.829 1.069 50.528 1.00 54.34 ? 133 CYS A O 1 ATOM 1050 C CB . CYS A 1 133 ? -16.585 3.572 49.496 1.00 54.45 ? 133 CYS A CB 1 ATOM 1051 S SG . CYS A 1 133 ? -16.400 5.112 48.523 1.00 50.98 ? 133 CYS A SG 1 ATOM 1052 N N . ILE A 1 134 ? -19.058 0.837 50.141 1.00 54.07 ? 134 ILE A N 1 ATOM 1053 C CA . ILE A 1 134 ? -19.158 -0.473 50.782 1.00 53.31 ? 134 ILE A CA 1 ATOM 1054 C C . ILE A 1 134 ? -19.345 -1.645 49.822 1.00 52.79 ? 134 ILE A C 1 ATOM 1055 O O . ILE A 1 134 ? -20.463 -1.921 49.350 1.00 52.61 ? 134 ILE A O 1 ATOM 1056 C CB . ILE A 1 134 ? -20.293 -0.558 51.828 1.00 53.23 ? 134 ILE A CB 1 ATOM 1057 C CG1 . ILE A 1 134 ? -20.561 0.785 52.491 1.00 53.34 ? 134 ILE A CG1 1 ATOM 1058 C CG2 . ILE A 1 134 ? -19.961 -1.644 52.872 1.00 53.15 ? 134 ILE A CG2 1 ATOM 1059 C CD1 . ILE A 1 134 ? -21.887 0.800 53.237 1.00 54.99 ? 134 ILE A CD1 1 ATOM 1060 N N . GLN A 1 135 ? -18.248 -2.355 49.582 1.00 52.03 ? 135 GLN A N 1 ATOM 1061 C CA . GLN A 1 135 ? -18.275 -3.610 48.849 1.00 51.48 ? 135 GLN A CA 1 ATOM 1062 C C . GLN A 1 135 ? -19.357 -4.445 49.480 1.00 51.70 ? 135 GLN A C 1 ATOM 1063 O O . GLN A 1 135 ? -19.302 -4.714 50.674 1.00 52.43 ? 135 GLN A O 1 ATOM 1064 C CB . GLN A 1 135 ? -16.928 -4.321 48.960 1.00 51.16 ? 135 GLN A CB 1 ATOM 1065 C CG . GLN A 1 135 ? -16.799 -5.575 48.139 1.00 49.20 ? 135 GLN A CG 1 ATOM 1066 C CD . GLN A 1 135 ? -15.357 -5.932 47.892 1.00 47.31 ? 135 GLN A CD 1 ATOM 1067 O OE1 . GLN A 1 135 ? -14.616 -5.172 47.267 1.00 47.72 ? 135 GLN A OE1 1 ATOM 1068 N NE2 . GLN A 1 135 ? -14.943 -7.090 48.378 1.00 45.49 ? 135 GLN A NE2 1 ATOM 1069 N N . GLY A 1 136 ? -20.333 -4.845 48.673 1.00 51.56 ? 136 GLY A N 1 ATOM 1070 C CA . GLY A 1 136 ? -21.573 -5.389 49.171 1.00 50.82 ? 136 GLY A CA 1 ATOM 1071 C C . GLY A 1 136 ? -22.029 -6.627 48.454 1.00 50.47 ? 136 GLY A C 1 ATOM 1072 O O . GLY A 1 136 ? -21.418 -7.677 48.585 1.00 50.49 ? 136 GLY A O 1 ATOM 1073 N N . ASP A 1 137 ? -23.138 -6.515 47.733 1.00 50.37 ? 137 ASP A N 1 ATOM 1074 C CA . ASP A 1 137 ? -23.693 -7.655 47.020 1.00 50.33 ? 137 ASP A CA 1 ATOM 1075 C C . ASP A 1 137 ? -23.597 -7.695 45.508 1.00 50.05 ? 137 ASP A C 1 ATOM 1076 O O . ASP A 1 137 ? -23.195 -8.696 44.919 1.00 50.39 ? 137 ASP A O 1 ATOM 1077 C CB . ASP A 1 137 ? -25.218 -7.677 47.161 1.00 50.81 ? 137 ASP A CB 1 ATOM 1078 C CG . ASP A 1 137 ? -25.689 -8.526 48.332 1.00 51.83 ? 137 ASP A CG 1 ATOM 1079 O OD1 . ASP A 1 137 ? -25.633 -9.777 48.217 1.00 51.61 ? 137 ASP A OD1 1 ATOM 1080 O OD2 . ASP A 1 137 ? -26.131 -7.943 49.356 1.00 51.86 ? 137 ASP A OD2 1 ATOM 1081 N N . ASN A 1 138 ? -23.941 -6.588 44.878 1.00 49.53 ? 138 ASN A N 1 ATOM 1082 C CA . ASN A 1 138 ? -23.523 -6.252 43.534 1.00 49.35 ? 138 ASN A CA 1 ATOM 1083 C C . ASN A 1 138 ? -22.813 -4.884 43.487 1.00 48.71 ? 138 ASN A C 1 ATOM 1084 O O . ASN A 1 138 ? -22.626 -4.308 42.416 1.00 48.66 ? 138 ASN A O 1 ATOM 1085 C CB . ASN A 1 138 ? -24.713 -6.337 42.572 1.00 49.60 ? 138 ASN A CB 1 ATOM 1086 C CG . ASN A 1 138 ? -25.199 -7.777 42.368 1.00 51.04 ? 138 ASN A CG 1 ATOM 1087 O OD1 . ASN A 1 138 ? -24.399 -8.736 42.344 1.00 52.30 ? 138 ASN A OD1 1 ATOM 1088 N ND2 . ASN A 1 138 ? -26.513 -7.935 42.219 1.00 50.95 ? 138 ASN A ND2 1 ATOM 1089 N N . CYS A 1 139 ? -22.415 -4.387 44.658 1.00 47.22 ? 139 CYS A N 1 ATOM 1090 C CA . CYS A 1 139 ? -21.669 -3.153 44.764 1.00 46.23 ? 139 CYS A CA 1 ATOM 1091 C C . CYS A 1 139 ? -20.227 -3.556 44.991 1.00 43.77 ? 139 CYS A C 1 ATOM 1092 O O . CYS A 1 139 ? -19.909 -4.326 45.899 1.00 43.35 ? 139 CYS A O 1 ATOM 1093 C CB . CYS A 1 139 ? -22.223 -2.282 45.897 1.00 47.63 ? 139 CYS A CB 1 ATOM 1094 S SG . CYS A 1 139 ? -21.161 -0.918 46.468 1.00 53.97 ? 139 CYS A SG 1 ATOM 1095 N N . PHE A 1 140 ? -19.357 -3.057 44.124 1.00 41.10 ? 140 PHE A N 1 ATOM 1096 C CA . PHE A 1 140 ? -17.996 -3.537 44.035 1.00 38.40 ? 140 PHE A CA 1 ATOM 1097 C C . PHE A 1 140 ? -17.149 -2.308 43.741 1.00 37.35 ? 140 PHE A C 1 ATOM 1098 O O . PHE A 1 140 ? -16.565 -2.195 42.654 1.00 37.14 ? 140 PHE A O 1 ATOM 1099 C CB . PHE A 1 140 ? -17.929 -4.605 42.931 1.00 37.92 ? 140 PHE A CB 1 ATOM 1100 C CG . PHE A 1 140 ? -16.557 -5.211 42.707 1.00 36.48 ? 140 PHE A CG 1 ATOM 1101 C CD1 . PHE A 1 140 ? -15.663 -5.401 43.755 1.00 35.93 ? 140 PHE A CD1 1 ATOM 1102 C CD2 . PHE A 1 140 ? -16.176 -5.622 41.423 1.00 33.76 ? 140 PHE A CD2 1 ATOM 1103 C CE1 . PHE A 1 140 ? -14.415 -5.986 43.535 1.00 33.22 ? 140 PHE A CE1 1 ATOM 1104 C CE2 . PHE A 1 140 ? -14.937 -6.199 41.192 1.00 31.68 ? 140 PHE A CE2 1 ATOM 1105 C CZ . PHE A 1 140 ? -14.054 -6.383 42.245 1.00 33.04 ? 140 PHE A CZ 1 ATOM 1106 N N . PRO A 1 141 ? -17.076 -1.372 44.722 1.00 35.84 ? 141 PRO A N 1 ATOM 1107 C CA . PRO A 1 141 ? -16.557 -0.052 44.418 1.00 34.61 ? 141 PRO A CA 1 ATOM 1108 C C . PRO A 1 141 ? -15.123 -0.110 43.978 1.00 33.29 ? 141 PRO A C 1 ATOM 1109 O O . PRO A 1 141 ? -14.397 -1.021 44.364 1.00 32.84 ? 141 PRO A O 1 ATOM 1110 C CB . PRO A 1 141 ? -16.678 0.697 45.755 1.00 34.29 ? 141 PRO A CB 1 ATOM 1111 C CG . PRO A 1 141 ? -16.743 -0.340 46.773 1.00 34.98 ? 141 PRO A CG 1 ATOM 1112 C CD . PRO A 1 141 ? -17.463 -1.473 46.142 1.00 35.63 ? 141 PRO A CD 1 ATOM 1113 N N . ILE A 1 142 ? -14.746 0.855 43.148 1.00 32.61 ? 142 ILE A N 1 ATOM 1114 C CA . ILE A 1 142 ? -13.376 1.003 42.668 1.00 31.85 ? 142 ILE A CA 1 ATOM 1115 C C . ILE A 1 142 ? -12.642 1.913 43.662 1.00 32.24 ? 142 ILE A C 1 ATOM 1116 O O . ILE A 1 142 ? -12.938 3.119 43.767 1.00 31.84 ? 142 ILE A O 1 ATOM 1117 C CB . ILE A 1 142 ? -13.364 1.583 41.235 1.00 31.34 ? 142 ILE A CB 1 ATOM 1118 C CG1 . ILE A 1 142 ? -14.204 0.707 40.291 1.00 30.12 ? 142 ILE A CG1 1 ATOM 1119 C CG2 . ILE A 1 142 ? -11.929 1.760 40.714 1.00 31.92 ? 142 ILE A CG2 1 ATOM 1120 C CD1 . ILE A 1 142 ? -14.370 1.269 38.871 1.00 24.87 ? 142 ILE A CD1 1 ATOM 1121 N N . MET A 1 143 ? -11.724 1.327 44.423 1.00 32.42 ? 143 MET A N 1 ATOM 1122 C CA . MET A 1 143 ? -11.089 2.064 45.512 1.00 33.02 ? 143 MET A CA 1 ATOM 1123 C C . MET A 1 143 ? -9.910 2.839 44.974 1.00 33.35 ? 143 MET A C 1 ATOM 1124 O O . MET A 1 143 ? -9.160 2.339 44.137 1.00 33.42 ? 143 MET A O 1 ATOM 1125 C CB . MET A 1 143 ? -10.639 1.153 46.686 1.00 33.09 ? 143 MET A CB 1 ATOM 1126 C CG . MET A 1 143 ? -11.732 0.323 47.371 1.00 32.46 ? 143 MET A CG 1 ATOM 1127 S SD . MET A 1 143 ? -13.183 1.163 48.076 1.00 38.84 ? 143 MET A SD 1 ATOM 1128 C CE . MET A 1 143 ? -12.496 2.009 49.505 1.00 32.57 ? 143 MET A CE 1 ATOM 1129 N N . PHE A 1 144 ? -9.768 4.073 45.451 1.00 34.02 ? 144 PHE A N 1 ATOM 1130 C CA . PHE A 1 144 ? -8.619 4.900 45.154 1.00 34.92 ? 144 PHE A CA 1 ATOM 1131 C C . PHE A 1 144 ? -7.366 4.431 45.870 1.00 35.90 ? 144 PHE A C 1 ATOM 1132 O O . PHE A 1 144 ? -7.440 4.035 47.029 1.00 36.71 ? 144 PHE A O 1 ATOM 1133 C CB . PHE A 1 144 ? -8.926 6.331 45.550 1.00 35.29 ? 144 PHE A CB 1 ATOM 1134 C CG . PHE A 1 144 ? -10.058 6.954 44.764 1.00 36.34 ? 144 PHE A CG 1 ATOM 1135 C CD1 . PHE A 1 144 ? -10.999 7.750 45.398 1.00 36.59 ? 144 PHE A CD1 1 ATOM 1136 C CD2 . PHE A 1 144 ? -10.186 6.735 43.391 1.00 35.57 ? 144 PHE A CD2 1 ATOM 1137 C CE1 . PHE A 1 144 ? -12.041 8.331 44.681 1.00 36.83 ? 144 PHE A CE1 1 ATOM 1138 C CE2 . PHE A 1 144 ? -11.214 7.316 42.680 1.00 34.93 ? 144 PHE A CE2 1 ATOM 1139 C CZ . PHE A 1 144 ? -12.141 8.110 43.324 1.00 36.40 ? 144 PHE A CZ 1 ATOM 1140 N N . PRO A 1 145 ? -6.207 4.443 45.178 1.00 36.64 ? 145 PRO A N 1 ATOM 1141 C CA . PRO A 1 145 ? -4.913 4.099 45.785 1.00 37.31 ? 145 PRO A CA 1 ATOM 1142 C C . PRO A 1 145 ? -4.349 5.237 46.644 1.00 38.85 ? 145 PRO A C 1 ATOM 1143 O O . PRO A 1 145 ? -4.796 6.378 46.526 1.00 38.93 ? 145 PRO A O 1 ATOM 1144 C CB . PRO A 1 145 ? -4.010 3.903 44.563 1.00 36.64 ? 145 PRO A CB 1 ATOM 1145 C CG . PRO A 1 145 ? -4.563 4.820 43.569 1.00 35.33 ? 145 PRO A CG 1 ATOM 1146 C CD . PRO A 1 145 ? -6.062 4.644 43.727 1.00 36.25 ? 145 PRO A CD 1 ATOM 1147 N N . LYS A 1 146 ? -3.337 4.932 47.459 1.00 40.22 ? 146 LYS A N 1 ATOM 1148 C CA . LYS A 1 146 ? -2.771 5.906 48.397 1.00 41.11 ? 146 LYS A CA 1 ATOM 1149 C C . LYS A 1 146 ? -2.626 7.312 47.813 1.00 41.13 ? 146 LYS A C 1 ATOM 1150 O O . LYS A 1 146 ? -3.080 8.284 48.421 1.00 41.96 ? 146 LYS A O 1 ATOM 1151 C CB . LYS A 1 146 ? -1.405 5.416 48.953 1.00 41.61 ? 146 LYS A CB 1 ATOM 1152 C CG . LYS A 1 146 ? -0.530 6.528 49.597 1.00 43.02 ? 146 LYS A CG 1 ATOM 1153 C CD . LYS A 1 146 ? 0.789 6.044 50.247 1.00 47.16 ? 146 LYS A CD 1 ATOM 1154 C CE . LYS A 1 146 ? 1.501 4.913 49.466 1.00 48.62 ? 146 LYS A CE 1 ATOM 1155 N NZ . LYS A 1 146 ? 1.009 3.550 49.853 1.00 49.01 ? 146 LYS A NZ 1 ATOM 1156 N N . ASN A 1 147 ? -1.991 7.428 46.653 1.00 40.37 ? 147 ASN A N 1 ATOM 1157 C CA . ASN A 1 147 ? -1.511 8.732 46.210 1.00 40.43 ? 147 ASN A CA 1 ATOM 1158 C C . ASN A 1 147 ? -2.457 9.540 45.280 1.00 39.65 ? 147 ASN A C 1 ATOM 1159 O O . ASN A 1 147 ? -2.095 10.597 44.747 1.00 39.31 ? 147 ASN A O 1 ATOM 1160 C CB . ASN A 1 147 ? -0.107 8.562 45.593 1.00 41.01 ? 147 ASN A CB 1 ATOM 1161 C CG . ASN A 1 147 ? 0.973 8.238 46.654 1.00 42.85 ? 147 ASN A CG 1 ATOM 1162 O OD1 . ASN A 1 147 ? 1.949 7.495 46.368 1.00 42.56 ? 147 ASN A OD1 1 ATOM 1163 N ND2 . ASN A 1 147 ? 0.806 8.797 47.882 1.00 39.36 ? 147 ASN A ND2 1 ATOM 1164 N N . ASP A 1 148 ? -3.673 9.039 45.117 1.00 38.36 ? 148 ASP A N 1 ATOM 1165 C CA . ASP A 1 148 ? -4.563 9.474 44.063 1.00 36.96 ? 148 ASP A CA 1 ATOM 1166 C C . ASP A 1 148 ? -5.128 10.872 44.322 1.00 36.04 ? 148 ASP A C 1 ATOM 1167 O O . ASP A 1 148 ? -5.755 11.108 45.355 1.00 35.93 ? 148 ASP A O 1 ATOM 1168 C CB . ASP A 1 148 ? -5.691 8.448 43.933 1.00 37.04 ? 148 ASP A CB 1 ATOM 1169 C CG . ASP A 1 148 ? -6.448 8.554 42.619 1.00 36.83 ? 148 ASP A CG 1 ATOM 1170 O OD1 . ASP A 1 148 ? -7.192 9.543 42.407 1.00 33.59 ? 148 ASP A OD1 1 ATOM 1171 O OD2 . ASP A 1 148 ? -6.315 7.607 41.816 1.00 38.03 ? 148 ASP A OD2 1 ATOM 1172 N N . PRO A 1 149 ? -4.952 11.791 43.355 1.00 35.49 ? 149 PRO A N 1 ATOM 1173 C CA . PRO A 1 149 ? -5.509 13.152 43.485 1.00 34.83 ? 149 PRO A CA 1 ATOM 1174 C C . PRO A 1 149 ? -6.998 13.200 43.788 1.00 34.59 ? 149 PRO A C 1 ATOM 1175 O O . PRO A 1 149 ? -7.447 14.111 44.483 1.00 34.61 ? 149 PRO A O 1 ATOM 1176 C CB . PRO A 1 149 ? -5.241 13.786 42.120 1.00 34.94 ? 149 PRO A CB 1 ATOM 1177 C CG . PRO A 1 149 ? -4.103 12.966 41.532 1.00 35.16 ? 149 PRO A CG 1 ATOM 1178 C CD . PRO A 1 149 ? -4.290 11.579 42.049 1.00 35.11 ? 149 PRO A CD 1 ATOM 1179 N N . LYS A 1 150 ? -7.759 12.244 43.263 1.00 34.28 ? 150 LYS A N 1 ATOM 1180 C CA . LYS A 1 150 ? -9.205 12.191 43.487 1.00 33.93 ? 150 LYS A CA 1 ATOM 1181 C C . LYS A 1 150 ? -9.670 12.026 44.958 1.00 33.96 ? 150 LYS A C 1 ATOM 1182 O O . LYS A 1 150 ? -10.804 12.385 45.315 1.00 33.61 ? 150 LYS A O 1 ATOM 1183 C CB . LYS A 1 150 ? -9.800 11.101 42.606 1.00 33.75 ? 150 LYS A CB 1 ATOM 1184 C CG . LYS A 1 150 ? -10.083 11.563 41.177 1.00 32.73 ? 150 LYS A CG 1 ATOM 1185 C CD . LYS A 1 150 ? -10.766 10.463 40.366 1.00 28.91 ? 150 LYS A CD 1 ATOM 1186 C CE . LYS A 1 150 ? -10.887 10.880 38.931 1.00 29.97 ? 150 LYS A CE 1 ATOM 1187 N NZ . LYS A 1 150 ? -11.660 12.141 38.757 1.00 25.62 ? 150 LYS A NZ 1 ATOM 1188 N N . LEU A 1 151 ? -8.784 11.492 45.794 1.00 34.23 ? 151 LEU A N 1 ATOM 1189 C CA . LEU A 1 151 ? -9.013 11.357 47.222 1.00 35.20 ? 151 LEU A CA 1 ATOM 1190 C C . LEU A 1 151 ? -9.249 12.756 47.842 1.00 35.89 ? 151 LEU A C 1 ATOM 1191 O O . LEU A 1 151 ? -10.041 12.915 48.774 1.00 36.51 ? 151 LEU A O 1 ATOM 1192 C CB . LEU A 1 151 ? -7.781 10.711 47.823 1.00 35.29 ? 151 LEU A CB 1 ATOM 1193 C CG . LEU A 1 151 ? -7.724 9.422 48.659 1.00 35.79 ? 151 LEU A CG 1 ATOM 1194 C CD1 . LEU A 1 151 ? -8.823 8.406 48.366 1.00 32.08 ? 151 LEU A CD1 1 ATOM 1195 C CD2 . LEU A 1 151 ? -6.318 8.811 48.490 1.00 33.20 ? 151 LEU A CD2 1 ATOM 1196 N N . LYS A 1 152 ? -8.602 13.762 47.268 1.00 36.34 ? 152 LYS A N 1 ATOM 1197 C CA . LYS A 1 152 ? -8.744 15.150 47.680 1.00 37.48 ? 152 LYS A CA 1 ATOM 1198 C C . LYS A 1 152 ? -10.059 15.791 47.278 1.00 37.84 ? 152 LYS A C 1 ATOM 1199 O O . LYS A 1 152 ? -10.504 16.727 47.953 1.00 37.83 ? 152 LYS A O 1 ATOM 1200 C CB . LYS A 1 152 ? -7.588 16.009 47.147 1.00 37.22 ? 152 LYS A CB 1 ATOM 1201 C CG . LYS A 1 152 ? -6.242 15.725 47.808 1.00 38.25 ? 152 LYS A CG 1 ATOM 1202 C CD . LYS A 1 152 ? -5.139 16.265 46.922 1.00 40.64 ? 152 LYS A CD 1 ATOM 1203 C CE . LYS A 1 152 ? -3.782 16.156 47.553 1.00 41.41 ? 152 LYS A CE 1 ATOM 1204 N NZ . LYS A 1 152 ? -2.803 16.868 46.676 1.00 43.82 ? 152 LYS A NZ 1 ATOM 1205 N N . THR A 1 153 ? -10.691 15.309 46.210 1.00 38.13 ? 153 THR A N 1 ATOM 1206 C CA . THR A 1 153 ? -11.887 16.017 45.694 1.00 38.82 ? 153 THR A CA 1 ATOM 1207 C C . THR A 1 153 ? -13.145 15.194 45.434 1.00 39.74 ? 153 THR A C 1 ATOM 1208 O O . THR A 1 153 ? -14.166 15.757 45.013 1.00 39.70 ? 153 THR A O 1 ATOM 1209 C CB . THR A 1 153 ? -11.616 16.803 44.392 1.00 38.24 ? 153 THR A CB 1 ATOM 1210 O OG1 . THR A 1 153 ? -11.158 15.901 43.382 1.00 36.50 ? 153 THR A OG1 1 ATOM 1211 C CG2 . THR A 1 153 ? -10.627 17.927 44.613 1.00 38.08 ? 153 THR A CG2 1 ATOM 1212 N N . GLN A 1 154 ? -13.080 13.884 45.666 1.00 40.74 ? 154 GLN A N 1 ATOM 1213 C CA . GLN A 1 154 ? -14.233 13.039 45.401 1.00 41.19 ? 154 GLN A CA 1 ATOM 1214 C C . GLN A 1 154 ? -14.709 12.074 46.478 1.00 42.26 ? 154 GLN A C 1 ATOM 1215 O O . GLN A 1 154 ? -15.905 11.759 46.552 1.00 43.14 ? 154 GLN A O 1 ATOM 1216 C CB . GLN A 1 154 ? -13.976 12.164 44.196 1.00 40.15 ? 154 GLN A CB 1 ATOM 1217 C CG . GLN A 1 154 ? -14.451 12.771 42.935 1.00 39.00 ? 154 GLN A CG 1 ATOM 1218 C CD . GLN A 1 154 ? -14.191 11.899 41.712 1.00 37.69 ? 154 GLN A CD 1 ATOM 1219 O OE1 . GLN A 1 154 ? -13.625 12.374 40.756 1.00 34.38 ? 154 GLN A OE1 1 ATOM 1220 N NE2 . GLN A 1 154 ? -14.621 10.625 41.741 1.00 36.87 ? 154 GLN A NE2 1 ATOM 1221 N N . GLY A 1 155 ? -13.730 11.455 47.164 1.00 42.72 ? 155 GLY A N 1 ATOM 1222 C CA . GLY A 1 155 ? -14.063 10.591 48.285 1.00 42.87 ? 155 GLY A CA 1 ATOM 1223 C C . GLY A 1 155 ? -13.106 9.433 48.152 1.00 43.14 ? 155 GLY A C 1 ATOM 1224 O O . GLY A 1 155 ? -11.989 9.597 47.645 1.00 42.89 ? 155 GLY A O 1 ATOM 1225 N N . LYS A 1 156 ? -13.549 8.261 48.594 1.00 43.14 ? 156 LYS A N 1 ATOM 1226 C CA . LYS A 1 156 ? -12.649 7.146 48.819 1.00 43.68 ? 156 LYS A CA 1 ATOM 1227 C C . LYS A 1 156 ? -12.650 6.139 47.668 1.00 43.32 ? 156 LYS A C 1 ATOM 1228 O O . LYS A 1 156 ? -11.707 5.342 47.511 1.00 44.06 ? 156 LYS A O 1 ATOM 1229 C CB . LYS A 1 156 ? -12.972 6.454 50.158 1.00 44.30 ? 156 LYS A CB 1 ATOM 1230 C CG . LYS A 1 156 ? -12.668 7.293 51.429 1.00 46.60 ? 156 LYS A CG 1 ATOM 1231 C CD . LYS A 1 156 ? -11.148 7.409 51.744 1.00 49.35 ? 156 LYS A CD 1 ATOM 1232 C CE . LYS A 1 156 ? -10.824 8.580 52.719 1.00 50.26 ? 156 LYS A CE 1 ATOM 1233 N NZ . LYS A 1 156 ? -9.352 8.734 52.991 1.00 48.19 ? 156 LYS A NZ 1 ATOM 1234 N N . CYS A 1 157 ? -13.692 6.194 46.851 1.00 42.51 ? 157 CYS A N 1 ATOM 1235 C CA . CYS A 1 157 ? -13.858 5.257 45.762 1.00 41.66 ? 157 CYS A CA 1 ATOM 1236 C C . CYS A 1 157 ? -14.574 5.923 44.594 1.00 41.02 ? 157 CYS A C 1 ATOM 1237 O O . CYS A 1 157 ? -15.003 7.082 44.697 1.00 40.06 ? 157 CYS A O 1 ATOM 1238 C CB . CYS A 1 157 ? -14.684 4.072 46.250 1.00 41.74 ? 157 CYS A CB 1 ATOM 1239 S SG . CYS A 1 157 ? -16.397 4.518 46.539 1.00 41.58 ? 157 CYS A SG 1 ATOM 1240 N N . MET A 1 158 ? -14.676 5.184 43.486 1.00 40.13 ? 158 MET A N 1 ATOM 1241 C CA . MET A 1 158 ? -15.740 5.400 42.503 1.00 39.72 ? 158 MET A CA 1 ATOM 1242 C C . MET A 1 158 ? -16.782 4.256 42.619 1.00 39.50 ? 158 MET A C 1 ATOM 1243 O O . MET A 1 158 ? -16.407 3.071 42.677 1.00 39.14 ? 158 MET A O 1 ATOM 1244 C CB . MET A 1 158 ? -15.190 5.459 41.080 1.00 39.76 ? 158 MET A CB 1 ATOM 1245 C CG . MET A 1 158 ? -14.190 6.563 40.800 1.00 39.62 ? 158 MET A CG 1 ATOM 1246 S SD . MET A 1 158 ? -13.152 6.113 39.374 1.00 42.66 ? 158 MET A SD 1 ATOM 1247 C CE . MET A 1 158 ? -12.332 7.642 39.075 1.00 37.49 ? 158 MET A CE 1 ATOM 1248 N N . PRO A 1 159 ? -18.089 4.606 42.671 1.00 39.23 ? 159 PRO A N 1 ATOM 1249 C CA . PRO A 1 159 ? -19.184 3.620 42.645 1.00 38.76 ? 159 PRO A CA 1 ATOM 1250 C C . PRO A 1 159 ? -19.133 2.711 41.422 1.00 37.99 ? 159 PRO A C 1 ATOM 1251 O O . PRO A 1 159 ? -18.867 3.180 40.310 1.00 37.54 ? 159 PRO A O 1 ATOM 1252 C CB . PRO A 1 159 ? -20.455 4.490 42.563 1.00 39.23 ? 159 PRO A CB 1 ATOM 1253 C CG . PRO A 1 159 ? -19.969 5.835 42.053 1.00 40.13 ? 159 PRO A CG 1 ATOM 1254 C CD . PRO A 1 159 ? -18.612 5.984 42.721 1.00 39.47 ? 159 PRO A CD 1 ATOM 1255 N N . PHE A 1 160 ? -19.399 1.424 41.631 1.00 37.44 ? 160 PHE A N 1 ATOM 1256 C CA . PHE A 1 160 ? -19.359 0.441 40.548 1.00 37.00 ? 160 PHE A CA 1 ATOM 1257 C C . PHE A 1 160 ? -20.241 -0.730 40.897 1.00 36.81 ? 160 PHE A C 1 ATOM 1258 O O . PHE A 1 160 ? -20.129 -1.297 41.971 1.00 37.17 ? 160 PHE A O 1 ATOM 1259 C CB . PHE A 1 160 ? -17.915 -0.044 40.330 1.00 37.00 ? 160 PHE A CB 1 ATOM 1260 C CG . PHE A 1 160 ? -17.769 -1.135 39.290 1.00 35.97 ? 160 PHE A CG 1 ATOM 1261 C CD1 . PHE A 1 160 ? -17.281 -0.837 38.019 1.00 34.47 ? 160 PHE A CD1 1 ATOM 1262 C CD2 . PHE A 1 160 ? -18.074 -2.468 39.599 1.00 34.28 ? 160 PHE A CD2 1 ATOM 1263 C CE1 . PHE A 1 160 ? -17.099 -1.841 37.070 1.00 33.97 ? 160 PHE A CE1 1 ATOM 1264 C CE2 . PHE A 1 160 ? -17.912 -3.468 38.656 1.00 33.14 ? 160 PHE A CE2 1 ATOM 1265 C CZ . PHE A 1 160 ? -17.416 -3.161 37.391 1.00 33.45 ? 160 PHE A CZ 1 ATOM 1266 N N . PHE A 1 161 ? -21.096 -1.110 39.966 1.00 36.84 ? 161 PHE A N 1 ATOM 1267 C CA . PHE A 1 161 ? -22.070 -2.139 40.217 1.00 36.53 ? 161 PHE A CA 1 ATOM 1268 C C . PHE A 1 161 ? -21.948 -3.299 39.240 1.00 36.00 ? 161 PHE A C 1 ATOM 1269 O O . PHE A 1 161 ? -22.045 -3.131 38.022 1.00 35.94 ? 161 PHE A O 1 ATOM 1270 C CB . PHE A 1 161 ? -23.451 -1.523 40.145 1.00 36.99 ? 161 PHE A CB 1 ATOM 1271 C CG . PHE A 1 161 ? -23.659 -0.413 41.128 1.00 41.41 ? 161 PHE A CG 1 ATOM 1272 C CD1 . PHE A 1 161 ? -23.354 0.922 40.775 1.00 43.56 ? 161 PHE A CD1 1 ATOM 1273 C CD2 . PHE A 1 161 ? -24.160 -0.691 42.417 1.00 43.34 ? 161 PHE A CD2 1 ATOM 1274 C CE1 . PHE A 1 161 ? -23.529 1.958 41.681 1.00 44.15 ? 161 PHE A CE1 1 ATOM 1275 C CE2 . PHE A 1 161 ? -24.357 0.331 43.330 1.00 45.78 ? 161 PHE A CE2 1 ATOM 1276 C CZ . PHE A 1 161 ? -24.046 1.672 42.961 1.00 46.88 ? 161 PHE A CZ 1 ATOM 1277 N N . ARG A 1 162 ? -21.745 -4.486 39.788 1.00 35.94 ? 162 ARG A N 1 ATOM 1278 C CA . ARG A 1 162 ? -21.533 -5.686 38.991 1.00 35.43 ? 162 ARG A CA 1 ATOM 1279 C C . ARG A 1 162 ? -22.554 -5.859 37.875 1.00 35.89 ? 162 ARG A C 1 ATOM 1280 O O . ARG A 1 162 ? -23.734 -5.573 38.070 1.00 35.91 ? 162 ARG A O 1 ATOM 1281 C CB . ARG A 1 162 ? -21.522 -6.916 39.886 1.00 34.89 ? 162 ARG A CB 1 ATOM 1282 C CG . ARG A 1 162 ? -20.430 -6.915 40.918 1.00 33.33 ? 162 ARG A CG 1 ATOM 1283 C CD . ARG A 1 162 ? -20.259 -8.294 41.524 1.00 32.53 ? 162 ARG A CD 1 ATOM 1284 N NE . ARG A 1 162 ? -19.604 -9.228 40.609 1.00 34.17 ? 162 ARG A NE 1 ATOM 1285 C CZ . ARG A 1 162 ? -19.564 -10.548 40.781 1.00 33.77 ? 162 ARG A CZ 1 ATOM 1286 N NH1 . ARG A 1 162 ? -20.173 -11.089 41.830 1.00 32.25 ? 162 ARG A NH1 1 ATOM 1287 N NH2 . ARG A 1 162 ? -18.940 -11.329 39.895 1.00 30.06 ? 162 ARG A NH2 1 ATOM 1288 N N . ALA A 1 163 ? -22.083 -6.308 36.703 1.00 36.16 ? 163 ALA A N 1 ATOM 1289 C CA . ALA A 1 163 ? -22.957 -6.690 35.585 1.00 36.80 ? 163 ALA A CA 1 ATOM 1290 C C . ALA A 1 163 ? -23.985 -7.760 35.960 1.00 37.87 ? 163 ALA A C 1 ATOM 1291 O O . ALA A 1 163 ? -23.722 -8.626 36.787 1.00 37.47 ? 163 ALA A O 1 ATOM 1292 C CB . ALA A 1 163 ? -22.123 -7.173 34.405 1.00 36.51 ? 163 ALA A CB 1 ATOM 1293 N N . GLY A 1 164 ? -25.157 -7.687 35.333 1.00 39.97 ? 164 GLY A N 1 ATOM 1294 C CA . GLY A 1 164 ? -26.182 -8.728 35.430 1.00 42.17 ? 164 GLY A CA 1 ATOM 1295 C C . GLY A 1 164 ? -25.747 -10.110 34.944 1.00 44.27 ? 164 GLY A C 1 ATOM 1296 O O . GLY A 1 164 ? -24.761 -10.261 34.200 1.00 43.13 ? 164 GLY A O 1 ATOM 1297 N N . PHE A 1 165 ? -26.508 -11.114 35.355 1.00 46.57 ? 165 PHE A N 1 ATOM 1298 C CA . PHE A 1 165 ? -26.197 -12.505 35.048 1.00 49.77 ? 165 PHE A CA 1 ATOM 1299 C C . PHE A 1 165 ? -27.490 -13.302 34.881 1.00 51.76 ? 165 PHE A C 1 ATOM 1300 O O . PHE A 1 165 ? -28.500 -12.959 35.500 1.00 51.74 ? 165 PHE A O 1 ATOM 1301 C CB . PHE A 1 165 ? -25.340 -13.099 36.160 1.00 49.41 ? 165 PHE A CB 1 ATOM 1302 C CG . PHE A 1 165 ? -25.950 -12.968 37.538 1.00 50.61 ? 165 PHE A CG 1 ATOM 1303 C CD1 . PHE A 1 165 ? -26.516 -14.079 38.173 1.00 50.56 ? 165 PHE A CD1 1 ATOM 1304 C CD2 . PHE A 1 165 ? -25.960 -11.741 38.201 1.00 51.07 ? 165 PHE A CD2 1 ATOM 1305 C CE1 . PHE A 1 165 ? -27.073 -13.977 39.442 1.00 50.33 ? 165 PHE A CE1 1 ATOM 1306 C CE2 . PHE A 1 165 ? -26.518 -11.628 39.477 1.00 51.41 ? 165 PHE A CE2 1 ATOM 1307 C CZ . PHE A 1 165 ? -27.071 -12.752 40.098 1.00 52.01 ? 165 PHE A CZ 1 ATOM 1308 N N . VAL A 1 166 ? -27.441 -14.360 34.063 1.00 54.43 ? 166 VAL A N 1 ATOM 1309 C CA . VAL A 1 166 ? -28.629 -15.123 33.647 1.00 57.20 ? 166 VAL A CA 1 ATOM 1310 C C . VAL A 1 166 ? -29.272 -16.009 34.714 1.00 59.69 ? 166 VAL A C 1 ATOM 1311 O O . VAL A 1 166 ? -28.599 -16.473 35.642 1.00 59.47 ? 166 VAL A O 1 ATOM 1312 C CB . VAL A 1 166 ? -28.374 -15.998 32.376 1.00 57.32 ? 166 VAL A CB 1 ATOM 1313 C CG1 . VAL A 1 166 ? -28.763 -15.246 31.096 1.00 57.05 ? 166 VAL A CG1 1 ATOM 1314 C CG2 . VAL A 1 166 ? -26.936 -16.524 32.317 1.00 56.46 ? 166 VAL A CG2 1 ATOM 1315 N N . CYS A 1 167 ? -30.583 -16.222 34.544 1.00 62.93 ? 167 CYS A N 1 ATOM 1316 C CA . CYS A 1 167 ? -31.437 -17.101 35.382 1.00 66.48 ? 167 CYS A CA 1 ATOM 1317 C C . CYS A 1 167 ? -31.423 -16.053 36.529 1.00 67.32 ? 167 CYS A C 1 ATOM 1318 O O . CYS A 1 167 ? -31.630 -14.861 36.258 1.00 67.24 ? 167 CYS A O 1 ATOM 1319 C CB . CYS A 1 167 ? -30.757 -18.452 35.673 1.00 67.25 ? 167 CYS A CB 1 ATOM 1320 S SG . CYS A 1 167 ? -30.396 -19.389 34.199 1.00 72.29 ? 167 CYS A SG 1 ATOM 1321 N N . PRO A 1 168 ? -31.216 -16.483 37.797 1.00 68.42 ? 168 PRO A N 1 ATOM 1322 C CA . PRO A 1 168 ? -31.844 -15.944 38.995 1.00 69.36 ? 168 PRO A CA 1 ATOM 1323 C C . PRO A 1 168 ? -31.178 -14.569 38.901 1.00 70.33 ? 168 PRO A C 1 ATOM 1324 O O . PRO A 1 168 ? -30.344 -14.309 38.026 1.00 70.53 ? 168 PRO A O 1 ATOM 1325 C CB . PRO A 1 168 ? -31.295 -16.743 40.187 1.00 69.43 ? 168 PRO A CB 1 ATOM 1326 C CG . PRO A 1 168 ? -31.604 -18.139 39.842 1.00 69.17 ? 168 PRO A CG 1 ATOM 1327 C CD . PRO A 1 168 ? -31.418 -18.222 38.326 1.00 68.76 ? 168 PRO A CD 1 ATOM 1328 N N . THR A 1 169 ? -31.579 -13.704 39.826 1.00 71.29 ? 169 THR A N 1 ATOM 1329 C CA . THR A 1 169 ? -31.229 -12.299 39.843 1.00 71.80 ? 169 THR A CA 1 ATOM 1330 C C . THR A 1 169 ? -31.474 -11.749 41.275 1.00 72.76 ? 169 THR A C 1 ATOM 1331 O O . THR A 1 169 ? -30.711 -10.885 41.736 1.00 73.12 ? 169 THR A O 1 ATOM 1332 C CB . THR A 1 169 ? -32.015 -11.534 38.739 1.00 71.67 ? 169 THR A CB 1 ATOM 1333 O OG1 . THR A 1 169 ? -31.698 -12.091 37.450 1.00 70.83 ? 169 THR A OG1 1 ATOM 1334 C CG2 . THR A 1 169 ? -31.699 -10.043 38.752 1.00 71.52 ? 169 THR A CG2 1 ATOM 1335 N N . PRO A 1 170 ? -32.524 -12.250 41.992 1.00 73.33 ? 170 PRO A N 1 ATOM 1336 C CA . PRO A 1 170 ? -32.657 -11.898 43.429 1.00 73.66 ? 170 PRO A CA 1 ATOM 1337 C C . PRO A 1 170 ? -31.895 -12.459 44.677 1.00 73.71 ? 170 PRO A C 1 ATOM 1338 O O . PRO A 1 170 ? -31.592 -11.664 45.579 1.00 73.64 ? 170 PRO A O 1 ATOM 1339 C CB . PRO A 1 170 ? -34.102 -12.320 43.774 1.00 73.65 ? 170 PRO A CB 1 ATOM 1340 C CG . PRO A 1 170 ? -34.820 -12.304 42.460 1.00 73.47 ? 170 PRO A CG 1 ATOM 1341 C CD . PRO A 1 170 ? -33.791 -12.810 41.475 1.00 73.41 ? 170 PRO A CD 1 ATOM 1342 N N . PRO A 1 171 ? -31.627 -13.794 44.756 1.00 73.72 ? 171 PRO A N 1 ATOM 1343 C CA . PRO A 1 171 ? -30.449 -14.443 45.369 1.00 73.63 ? 171 PRO A CA 1 ATOM 1344 C C . PRO A 1 171 ? -29.924 -15.684 44.599 1.00 73.41 ? 171 PRO A C 1 ATOM 1345 O O . PRO A 1 171 ? -30.720 -16.564 44.231 1.00 73.45 ? 171 PRO A O 1 ATOM 1346 C CB . PRO A 1 171 ? -30.978 -14.855 46.746 1.00 73.56 ? 171 PRO A CB 1 ATOM 1347 C CG . PRO A 1 171 ? -32.501 -15.050 46.539 1.00 73.85 ? 171 PRO A CG 1 ATOM 1348 C CD . PRO A 1 171 ? -32.852 -14.518 45.150 1.00 74.01 ? 171 PRO A CD 1 ATOM 1349 N N . TYR A 1 172 ? -28.602 -15.754 44.383 1.00 73.01 ? 172 TYR A N 1 ATOM 1350 C CA . TYR A 1 172 ? -27.981 -16.802 43.537 1.00 72.52 ? 172 TYR A CA 1 ATOM 1351 C C . TYR A 1 172 ? -26.636 -17.345 44.066 1.00 71.53 ? 172 TYR A C 1 ATOM 1352 O O . TYR A 1 172 ? -25.883 -16.592 44.701 1.00 71.43 ? 172 TYR A O 1 ATOM 1353 C CB . TYR A 1 172 ? -27.808 -16.270 42.099 1.00 73.09 ? 172 TYR A CB 1 ATOM 1354 C CG . TYR A 1 172 ? -27.139 -17.230 41.124 1.00 74.11 ? 172 TYR A CG 1 ATOM 1355 C CD1 . TYR A 1 172 ? -27.829 -18.342 40.626 1.00 75.13 ? 172 TYR A CD1 1 ATOM 1356 C CD2 . TYR A 1 172 ? -25.817 -17.022 40.700 1.00 74.93 ? 172 TYR A CD2 1 ATOM 1357 C CE1 . TYR A 1 172 ? -27.224 -19.227 39.734 1.00 76.04 ? 172 TYR A CE1 1 ATOM 1358 C CE2 . TYR A 1 172 ? -25.198 -17.900 39.806 1.00 75.54 ? 172 TYR A CE2 1 ATOM 1359 C CZ . TYR A 1 172 ? -25.910 -19.001 39.327 1.00 76.36 ? 172 TYR A CZ 1 ATOM 1360 O OH . TYR A 1 172 ? -25.319 -19.885 38.449 1.00 76.10 ? 172 TYR A OH 1 ATOM 1361 N N . GLN A 1 173 ? -26.391 -18.646 43.866 1.00 70.31 ? 173 GLN A N 1 ATOM 1362 C CA . GLN A 1 173 ? -25.137 -19.332 44.237 1.00 69.11 ? 173 GLN A CA 1 ATOM 1363 C C . GLN A 1 173 ? -24.795 -20.791 43.709 1.00 68.01 ? 173 GLN A C 1 ATOM 1364 O O . GLN A 1 173 ? -24.039 -21.500 44.344 1.00 67.98 ? 173 GLN A O 1 ATOM 1365 C CB . GLN A 1 173 ? -24.784 -19.122 45.713 1.00 69.27 ? 173 GLN A CB 1 ATOM 1366 C CG . GLN A 1 173 ? -25.783 -19.626 46.726 1.00 69.95 ? 173 GLN A CG 1 ATOM 1367 C CD . GLN A 1 173 ? -26.780 -18.596 47.130 1.00 70.73 ? 173 GLN A CD 1 ATOM 1368 O OE1 . GLN A 1 173 ? -26.427 -17.464 47.426 1.00 71.41 ? 173 GLN A OE1 1 ATOM 1369 N NE2 . GLN A 1 173 ? -28.041 -18.974 47.131 1.00 70.09 ? 173 GLN A NE2 1 ATOM 1370 N N . SER A 1 174 ? -25.378 -21.274 42.616 1.00 66.32 ? 174 SER A N 1 ATOM 1371 C CA . SER A 1 174 ? -25.142 -22.659 42.188 1.00 64.20 ? 174 SER A CA 1 ATOM 1372 C C . SER A 1 174 ? -24.164 -23.090 41.086 1.00 62.66 ? 174 SER A C 1 ATOM 1373 O O . SER A 1 174 ? -23.317 -23.949 41.343 1.00 62.73 ? 174 SER A O 1 ATOM 1374 C CB . SER A 1 174 ? -26.496 -23.313 41.845 1.00 64.47 ? 174 SER A CB 1 ATOM 1375 O OG . SER A 1 174 ? -27.623 -22.648 42.417 1.00 64.76 ? 174 SER A OG 1 ATOM 1376 N N . LEU A 1 175 ? -24.231 -22.484 39.910 1.00 60.06 ? 175 LEU A N 1 ATOM 1377 C CA . LEU A 1 175 ? -23.254 -22.677 38.789 1.00 56.79 ? 175 LEU A CA 1 ATOM 1378 C C . LEU A 1 175 ? -22.407 -21.404 38.577 1.00 53.87 ? 175 LEU A C 1 ATOM 1379 O O . LEU A 1 175 ? -22.605 -20.417 39.285 1.00 54.13 ? 175 LEU A O 1 ATOM 1380 C CB . LEU A 1 175 ? -24.018 -23.042 37.497 1.00 57.15 ? 175 LEU A CB 1 ATOM 1381 C CG . LEU A 1 175 ? -23.379 -23.692 36.261 1.00 57.76 ? 175 LEU A CG 1 ATOM 1382 C CD1 . LEU A 1 175 ? -22.419 -24.819 36.662 1.00 58.05 ? 175 LEU A CD1 1 ATOM 1383 C CD2 . LEU A 1 175 ? -24.477 -24.197 35.292 1.00 58.44 ? 175 LEU A CD2 1 ATOM 1384 N N . ALA A 1 176 ? -21.476 -21.411 37.622 1.00 50.33 ? 176 ALA A N 1 ATOM 1385 C CA . ALA A 1 176 ? -20.605 -20.234 37.387 1.00 46.76 ? 176 ALA A CA 1 ATOM 1386 C C . ALA A 1 176 ? -21.402 -19.046 36.855 1.00 43.94 ? 176 ALA A C 1 ATOM 1387 O O . ALA A 1 176 ? -22.208 -19.214 35.941 1.00 43.64 ? 176 ALA A O 1 ATOM 1388 C CB . ALA A 1 176 ? -19.469 -20.579 36.453 1.00 46.45 ? 176 ALA A CB 1 ATOM 1389 N N . ARG A 1 177 ? -21.204 -17.872 37.458 1.00 40.67 ? 177 ARG A N 1 ATOM 1390 C CA . ARG A 1 177 ? -21.869 -16.626 37.014 1.00 37.89 ? 177 ARG A CA 1 ATOM 1391 C C . ARG A 1 177 ? -21.549 -16.215 35.561 1.00 36.04 ? 177 ARG A C 1 ATOM 1392 O O . ARG A 1 177 ? -20.389 -16.005 35.193 1.00 35.07 ? 177 ARG A O 1 ATOM 1393 C CB . ARG A 1 177 ? -21.570 -15.445 37.963 1.00 37.85 ? 177 ARG A CB 1 ATOM 1394 C CG . ARG A 1 177 ? -22.287 -14.158 37.515 1.00 37.78 ? 177 ARG A CG 1 ATOM 1395 C CD . ARG A 1 177 ? -21.934 -12.942 38.303 1.00 38.73 ? 177 ARG A CD 1 ATOM 1396 N NE . ARG A 1 177 ? -22.741 -12.820 39.505 1.00 41.06 ? 177 ARG A NE 1 ATOM 1397 C CZ . ARG A 1 177 ? -22.926 -11.689 40.174 1.00 39.68 ? 177 ARG A CZ 1 ATOM 1398 N NH1 . ARG A 1 177 ? -22.373 -10.566 39.761 1.00 40.60 ? 177 ARG A NH1 1 ATOM 1399 N NH2 . ARG A 1 177 ? -23.675 -11.684 41.256 1.00 40.39 ? 177 ARG A NH2 1 ATOM 1400 N N . GLU A 1 178 ? -22.601 -16.066 34.769 1.00 34.34 ? 178 GLU A N 1 ATOM 1401 C CA . GLU A 1 178 ? -22.495 -15.797 33.342 1.00 33.01 ? 178 GLU A CA 1 ATOM 1402 C C . GLU A 1 178 ? -23.247 -14.533 32.945 1.00 31.61 ? 178 GLU A C 1 ATOM 1403 O O . GLU A 1 178 ? -24.485 -14.517 32.971 1.00 32.54 ? 178 GLU A O 1 ATOM 1404 C CB . GLU A 1 178 ? -23.044 -16.981 32.526 1.00 32.59 ? 178 GLU A CB 1 ATOM 1405 C CG . GLU A 1 178 ? -22.336 -18.311 32.698 1.00 33.77 ? 178 GLU A CG 1 ATOM 1406 C CD . GLU A 1 178 ? -20.839 -18.283 32.304 1.00 37.33 ? 178 GLU A CD 1 ATOM 1407 O OE1 . GLU A 1 178 ? -20.139 -19.326 32.458 1.00 38.22 ? 178 GLU A OE1 1 ATOM 1408 O OE2 . GLU A 1 178 ? -20.355 -17.219 31.859 1.00 37.31 ? 178 GLU A OE2 1 ATOM 1409 N N . GLN A 1 179 ? -22.526 -13.492 32.534 1.00 29.38 ? 179 GLN A N 1 ATOM 1410 C CA . GLN A 1 179 ? -23.182 -12.226 32.206 1.00 27.79 ? 179 GLN A CA 1 ATOM 1411 C C . GLN A 1 179 ? -24.074 -12.281 30.957 1.00 27.96 ? 179 GLN A C 1 ATOM 1412 O O . GLN A 1 179 ? -23.784 -12.957 29.958 1.00 28.54 ? 179 GLN A O 1 ATOM 1413 C CB . GLN A 1 179 ? -22.178 -11.056 32.136 1.00 27.32 ? 179 GLN A CB 1 ATOM 1414 C CG . GLN A 1 179 ? -21.468 -10.707 33.456 1.00 23.79 ? 179 GLN A CG 1 ATOM 1415 C CD . GLN A 1 179 ? -20.599 -11.834 34.022 1.00 22.62 ? 179 GLN A CD 1 ATOM 1416 O OE1 . GLN A 1 179 ? -19.961 -12.587 33.279 1.00 18.21 ? 179 GLN A OE1 1 ATOM 1417 N NE2 . GLN A 1 179 ? -20.561 -11.944 35.364 1.00 24.47 ? 179 GLN A NE2 1 ATOM 1418 N N . ILE A 1 180 ? -25.165 -11.542 31.021 1.00 27.62 ? 180 ILE A N 1 ATOM 1419 C CA . ILE A 1 180 ? -26.124 -11.463 29.945 1.00 27.55 ? 180 ILE A CA 1 ATOM 1420 C C . ILE A 1 180 ? -25.678 -10.552 28.775 1.00 27.51 ? 180 ILE A C 1 ATOM 1421 O O . ILE A 1 180 ? -25.012 -9.520 28.977 1.00 28.21 ? 180 ILE A O 1 ATOM 1422 C CB . ILE A 1 180 ? -27.432 -10.951 30.492 1.00 27.68 ? 180 ILE A CB 1 ATOM 1423 C CG1 . ILE A 1 180 ? -27.818 -11.764 31.741 1.00 29.58 ? 180 ILE A CG1 1 ATOM 1424 C CG2 . ILE A 1 180 ? -28.538 -11.039 29.437 1.00 28.04 ? 180 ILE A CG2 1 ATOM 1425 C CD1 . ILE A 1 180 ? -29.122 -11.334 32.428 1.00 30.83 ? 180 ILE A CD1 1 ATOM 1426 N N . ASN A 1 181 ? -26.066 -10.927 27.561 1.00 25.36 ? 181 ASN A N 1 ATOM 1427 C CA . ASN A 1 181 ? -26.007 -10.012 26.457 1.00 24.96 ? 181 ASN A CA 1 ATOM 1428 C C . ASN A 1 181 ? -27.427 -9.544 26.082 1.00 24.28 ? 181 ASN A C 1 ATOM 1429 O O . ASN A 1 181 ? -28.230 -10.314 25.572 1.00 22.85 ? 181 ASN A O 1 ATOM 1430 C CB . ASN A 1 181 ? -25.262 -10.615 25.236 1.00 24.69 ? 181 ASN A CB 1 ATOM 1431 C CG . ASN A 1 181 ? -24.987 -9.566 24.158 1.00 25.45 ? 181 ASN A CG 1 ATOM 1432 O OD1 . ASN A 1 181 ? -25.358 -8.393 24.341 1.00 28.21 ? 181 ASN A OD1 1 ATOM 1433 N ND2 . ASN A 1 181 ? -24.327 -9.958 23.053 1.00 20.63 ? 181 ASN A ND2 1 ATOM 1434 N N . ALA A 1 182 ? -27.718 -8.267 26.329 1.00 24.06 ? 182 ALA A N 1 ATOM 1435 C CA . ALA A 1 182 ? -29.075 -7.712 26.079 1.00 23.81 ? 182 ALA A CA 1 ATOM 1436 C C . ALA A 1 182 ? -29.347 -7.257 24.621 1.00 23.51 ? 182 ALA A C 1 ATOM 1437 O O . ALA A 1 182 ? -30.415 -6.728 24.315 1.00 23.91 ? 182 ALA A O 1 ATOM 1438 C CB . ALA A 1 182 ? -29.347 -6.571 27.044 1.00 23.97 ? 182 ALA A CB 1 ATOM 1439 N N . VAL A 1 183 ? -28.364 -7.407 23.733 1.00 22.87 ? 183 VAL A N 1 ATOM 1440 C CA . VAL A 1 183 ? -28.582 -7.083 22.326 1.00 21.94 ? 183 VAL A CA 1 ATOM 1441 C C . VAL A 1 183 ? -28.379 -8.323 21.425 1.00 21.89 ? 183 VAL A C 1 ATOM 1442 O O . VAL A 1 183 ? -27.937 -9.366 21.889 1.00 21.60 ? 183 VAL A O 1 ATOM 1443 C CB . VAL A 1 183 ? -27.749 -5.838 21.896 1.00 22.38 ? 183 VAL A CB 1 ATOM 1444 C CG1 . VAL A 1 183 ? -27.901 -4.743 22.917 1.00 21.57 ? 183 VAL A CG1 1 ATOM 1445 C CG2 . VAL A 1 183 ? -26.269 -6.158 21.703 1.00 19.56 ? 183 VAL A CG2 1 ATOM 1446 N N . THR A 1 184 ? -28.689 -8.217 20.141 1.00 21.90 ? 184 THR A N 1 ATOM 1447 C CA . THR A 1 184 ? -28.587 -9.380 19.293 1.00 21.69 ? 184 THR A CA 1 ATOM 1448 C C . THR A 1 184 ? -27.142 -9.494 18.871 1.00 22.32 ? 184 THR A C 1 ATOM 1449 O O . THR A 1 184 ? -26.508 -8.493 18.522 1.00 23.42 ? 184 THR A O 1 ATOM 1450 C CB . THR A 1 184 ? -29.407 -9.226 17.998 1.00 21.77 ? 184 THR A CB 1 ATOM 1451 O OG1 . THR A 1 184 ? -28.902 -8.100 17.284 1.00 21.19 ? 184 THR A OG1 1 ATOM 1452 C CG2 . THR A 1 184 ? -30.879 -9.046 18.269 1.00 19.17 ? 184 THR A CG2 1 ATOM 1453 N N . SER A 1 185 ? -26.630 -10.711 18.840 1.00 22.26 ? 185 SER A N 1 ATOM 1454 C CA . SER A 1 185 ? -25.231 -10.945 18.499 1.00 22.19 ? 185 SER A CA 1 ATOM 1455 C C . SER A 1 185 ? -24.921 -10.649 17.031 1.00 22.31 ? 185 SER A C 1 ATOM 1456 O O . SER A 1 185 ? -23.771 -10.401 16.675 1.00 23.19 ? 185 SER A O 1 ATOM 1457 C CB . SER A 1 185 ? -24.898 -12.386 18.810 1.00 22.03 ? 185 SER A CB 1 ATOM 1458 O OG . SER A 1 185 ? -24.485 -12.494 20.153 1.00 24.03 ? 185 SER A OG 1 ATOM 1459 N N . PHE A 1 186 ? -25.964 -10.697 16.198 1.00 21.97 ? 186 PHE A N 1 ATOM 1460 C CA . PHE A 1 186 ? -25.896 -10.468 14.767 1.00 20.67 ? 186 PHE A CA 1 ATOM 1461 C C . PHE A 1 186 ? -25.680 -8.999 14.481 1.00 20.89 ? 186 PHE A C 1 ATOM 1462 O O . PHE A 1 186 ? -26.154 -8.144 15.231 1.00 20.39 ? 186 PHE A O 1 ATOM 1463 C CB . PHE A 1 186 ? -27.158 -11.000 14.060 1.00 20.25 ? 186 PHE A CB 1 ATOM 1464 C CG . PHE A 1 186 ? -27.497 -12.432 14.423 1.00 19.49 ? 186 PHE A CG 1 ATOM 1465 C CD1 . PHE A 1 186 ? -28.515 -12.712 15.323 1.00 20.96 ? 186 PHE A CD1 1 ATOM 1466 C CD2 . PHE A 1 186 ? -26.789 -13.489 13.887 1.00 17.52 ? 186 PHE A CD2 1 ATOM 1467 C CE1 . PHE A 1 186 ? -28.835 -14.014 15.671 1.00 17.45 ? 186 PHE A CE1 1 ATOM 1468 C CE2 . PHE A 1 186 ? -27.095 -14.810 14.232 1.00 16.20 ? 186 PHE A CE2 1 ATOM 1469 C CZ . PHE A 1 186 ? -28.090 -15.068 15.123 1.00 18.16 ? 186 PHE A CZ 1 ATOM 1470 N N . LEU A 1 187 ? -24.874 -8.737 13.445 1.00 20.93 ? 187 LEU A N 1 ATOM 1471 C CA . LEU A 1 187 ? -24.675 -7.430 12.912 1.00 21.37 ? 187 LEU A CA 1 ATOM 1472 C C . LEU A 1 187 ? -25.886 -7.119 12.042 1.00 22.63 ? 187 LEU A C 1 ATOM 1473 O O . LEU A 1 187 ? -25.893 -7.389 10.824 1.00 22.38 ? 187 LEU A O 1 ATOM 1474 C CB . LEU A 1 187 ? -23.412 -7.395 12.091 1.00 20.87 ? 187 LEU A CB 1 ATOM 1475 C CG . LEU A 1 187 ? -22.973 -5.972 11.796 1.00 22.00 ? 187 LEU A CG 1 ATOM 1476 C CD1 . LEU A 1 187 ? -22.921 -5.131 13.104 1.00 21.06 ? 187 LEU A CD1 1 ATOM 1477 C CD2 . LEU A 1 187 ? -21.603 -6.042 11.096 1.00 24.23 ? 187 LEU A CD2 1 ATOM 1478 N N . ASP A 1 188 ? -26.888 -6.508 12.681 1.00 23.38 ? 188 ASP A N 1 ATOM 1479 C CA . ASP A 1 188 ? -28.243 -6.507 12.194 1.00 24.50 ? 188 ASP A CA 1 ATOM 1480 C C . ASP A 1 188 ? -28.897 -5.136 12.083 1.00 25.84 ? 188 ASP A C 1 ATOM 1481 O O . ASP A 1 188 ? -30.047 -5.027 11.628 1.00 26.62 ? 188 ASP A O 1 ATOM 1482 C CB . ASP A 1 188 ? -28.997 -7.654 12.870 1.00 23.87 ? 188 ASP A CB 1 ATOM 1483 C CG . ASP A 1 188 ? -29.106 -7.473 14.371 1.00 23.86 ? 188 ASP A CG 1 ATOM 1484 O OD1 . ASP A 1 188 ? -28.587 -6.499 14.930 1.00 24.13 ? 188 ASP A OD1 1 ATOM 1485 O OD2 . ASP A 1 188 ? -29.692 -8.322 15.035 1.00 27.10 ? 188 ASP A OD2 1 ATOM 1486 N N . ALA A 1 189 ? -28.213 -4.097 12.537 1.00 26.24 ? 189 ALA A N 1 ATOM 1487 C CA . ALA A 1 189 ? -28.799 -2.790 12.911 1.00 26.69 ? 189 ALA A CA 1 ATOM 1488 C C . ALA A 1 189 ? -29.745 -2.829 14.126 1.00 26.38 ? 189 ALA A C 1 ATOM 1489 O O . ALA A 1 189 ? -30.693 -2.047 14.158 1.00 27.34 ? 189 ALA A O 1 ATOM 1490 C CB . ALA A 1 189 ? -29.582 -2.182 11.718 1.00 26.71 ? 189 ALA A CB 1 ATOM 1491 N N . SER A 1 190 ? -29.497 -3.676 15.133 1.00 25.41 ? 190 SER A N 1 ATOM 1492 C CA . SER A 1 190 ? -30.342 -3.660 16.362 1.00 24.64 ? 190 SER A CA 1 ATOM 1493 C C . SER A 1 190 ? -30.153 -2.435 17.243 1.00 25.07 ? 190 SER A C 1 ATOM 1494 O O . SER A 1 190 ? -30.815 -2.295 18.297 1.00 24.49 ? 190 SER A O 1 ATOM 1495 C CB . SER A 1 190 ? -30.118 -4.908 17.214 1.00 24.33 ? 190 SER A CB 1 ATOM 1496 O OG . SER A 1 190 ? -28.764 -5.025 17.630 1.00 24.37 ? 190 SER A OG 1 ATOM 1497 N N . LEU A 1 191 ? -29.211 -1.576 16.864 1.00 25.19 ? 191 LEU A N 1 ATOM 1498 C CA . LEU A 1 191 ? -28.975 -0.375 17.647 1.00 26.29 ? 191 LEU A CA 1 ATOM 1499 C C . LEU A 1 191 ? -29.914 0.716 17.173 1.00 26.83 ? 191 LEU A C 1 ATOM 1500 O O . LEU A 1 191 ? -30.198 1.656 17.901 1.00 26.13 ? 191 LEU A O 1 ATOM 1501 C CB . LEU A 1 191 ? -27.509 0.066 17.593 1.00 26.59 ? 191 LEU A CB 1 ATOM 1502 C CG . LEU A 1 191 ? -26.964 0.734 16.318 1.00 26.13 ? 191 LEU A CG 1 ATOM 1503 C CD1 . LEU A 1 191 ? -25.734 1.543 16.683 1.00 26.59 ? 191 LEU A CD1 1 ATOM 1504 C CD2 . LEU A 1 191 ? -26.654 -0.285 15.257 1.00 23.24 ? 191 LEU A CD2 1 ATOM 1505 N N . VAL A 1 192 ? -30.396 0.551 15.940 1.00 27.91 ? 192 VAL A N 1 ATOM 1506 C CA . VAL A 1 192 ? -31.393 1.426 15.337 1.00 28.41 ? 192 VAL A CA 1 ATOM 1507 C C . VAL A 1 192 ? -32.821 0.931 15.613 1.00 29.22 ? 192 VAL A C 1 ATOM 1508 O O . VAL A 1 192 ? -33.695 1.729 15.904 1.00 29.62 ? 192 VAL A O 1 ATOM 1509 C CB . VAL A 1 192 ? -31.152 1.533 13.853 1.00 28.48 ? 192 VAL A CB 1 ATOM 1510 C CG1 . VAL A 1 192 ? -32.096 2.534 13.213 1.00 29.37 ? 192 VAL A CG1 1 ATOM 1511 C CG2 . VAL A 1 192 ? -29.706 1.959 13.598 1.00 28.94 ? 192 VAL A CG2 1 ATOM 1512 N N . TYR A 1 193 ? -33.049 -0.381 15.568 1.00 29.52 ? 193 TYR A N 1 ATOM 1513 C CA . TYR A 1 193 ? -34.408 -0.906 15.746 1.00 29.87 ? 193 TYR A CA 1 ATOM 1514 C C . TYR A 1 193 ? -34.782 -1.454 17.118 1.00 30.38 ? 193 TYR A C 1 ATOM 1515 O O . TYR A 1 193 ? -35.973 -1.673 17.366 1.00 31.20 ? 193 TYR A O 1 ATOM 1516 C CB . TYR A 1 193 ? -34.755 -1.925 14.653 1.00 29.08 ? 193 TYR A CB 1 ATOM 1517 C CG . TYR A 1 193 ? -34.535 -1.342 13.301 1.00 27.74 ? 193 TYR A CG 1 ATOM 1518 C CD1 . TYR A 1 193 ? -33.372 -1.602 12.605 1.00 27.57 ? 193 TYR A CD1 1 ATOM 1519 C CD2 . TYR A 1 193 ? -35.465 -0.481 12.726 1.00 27.10 ? 193 TYR A CD2 1 ATOM 1520 C CE1 . TYR A 1 193 ? -33.134 -1.041 11.345 1.00 25.59 ? 193 TYR A CE1 1 ATOM 1521 C CE2 . TYR A 1 193 ? -35.234 0.094 11.450 1.00 24.64 ? 193 TYR A CE2 1 ATOM 1522 C CZ . TYR A 1 193 ? -34.058 -0.186 10.787 1.00 24.93 ? 193 TYR A CZ 1 ATOM 1523 O OH . TYR A 1 193 ? -33.787 0.353 9.547 1.00 25.85 ? 193 TYR A OH 1 ATOM 1524 N N . GLY A 1 194 ? -33.805 -1.658 18.002 1.00 30.03 ? 194 GLY A N 1 ATOM 1525 C CA . GLY A 1 194 ? -34.077 -2.272 19.286 1.00 30.49 ? 194 GLY A CA 1 ATOM 1526 C C . GLY A 1 194 ? -33.876 -3.776 19.224 1.00 31.68 ? 194 GLY A C 1 ATOM 1527 O O . GLY A 1 194 ? -33.819 -4.362 18.122 1.00 31.16 ? 194 GLY A O 1 ATOM 1528 N N . SER A 1 195 ? -33.719 -4.393 20.397 1.00 32.53 ? 195 SER A N 1 ATOM 1529 C CA . SER A 1 195 ? -33.570 -5.852 20.514 1.00 33.97 ? 195 SER A CA 1 ATOM 1530 C C . SER A 1 195 ? -34.757 -6.506 21.168 1.00 35.40 ? 195 SER A C 1 ATOM 1531 O O . SER A 1 195 ? -34.779 -7.726 21.311 1.00 35.94 ? 195 SER A O 1 ATOM 1532 C CB . SER A 1 195 ? -32.326 -6.202 21.339 1.00 33.44 ? 195 SER A CB 1 ATOM 1533 O OG . SER A 1 195 ? -31.151 -5.663 20.749 1.00 34.43 ? 195 SER A OG 1 ATOM 1534 N N . GLU A 1 196 ? -35.720 -5.695 21.599 1.00 36.80 ? 196 GLU A N 1 ATOM 1535 C CA . GLU A 1 196 ? -36.956 -6.190 22.215 1.00 38.99 ? 196 GLU A CA 1 ATOM 1536 C C . GLU A 1 196 ? -38.163 -5.713 21.387 1.00 39.46 ? 196 GLU A C 1 ATOM 1537 O O . GLU A 1 196 ? -38.208 -4.547 20.971 1.00 39.53 ? 196 GLU A O 1 ATOM 1538 C CB . GLU A 1 196 ? -37.086 -5.699 23.662 1.00 39.11 ? 196 GLU A CB 1 ATOM 1539 C CG . GLU A 1 196 ? -36.043 -6.233 24.630 1.00 42.00 ? 196 GLU A CG 1 ATOM 1540 C CD . GLU A 1 196 ? -36.018 -5.469 25.970 1.00 47.67 ? 196 GLU A CD 1 ATOM 1541 O OE1 . GLU A 1 196 ? -35.778 -4.215 25.982 1.00 49.29 ? 196 GLU A OE1 1 ATOM 1542 O OE2 . GLU A 1 196 ? -36.234 -6.136 27.013 1.00 47.75 ? 196 GLU A OE2 1 ATOM 1543 N N . PRO A 1 197 ? -39.136 -6.609 21.116 1.00 40.18 ? 197 PRO A N 1 ATOM 1544 C CA . PRO A 1 197 ? -40.302 -6.163 20.334 1.00 40.55 ? 197 PRO A CA 1 ATOM 1545 C C . PRO A 1 197 ? -41.080 -5.009 20.985 1.00 40.53 ? 197 PRO A C 1 ATOM 1546 O O . PRO A 1 197 ? -41.748 -4.247 20.297 1.00 40.13 ? 197 PRO A O 1 ATOM 1547 C CB . PRO A 1 197 ? -41.139 -7.439 20.232 1.00 40.19 ? 197 PRO A CB 1 ATOM 1548 C CG . PRO A 1 197 ? -40.099 -8.517 20.210 1.00 39.84 ? 197 PRO A CG 1 ATOM 1549 C CD . PRO A 1 197 ? -39.134 -8.078 21.264 1.00 40.26 ? 197 PRO A CD 1 HETATM 1550 N N . SEP A 1 198 ? -40.943 -4.886 22.297 1.00 41.42 ? 198 SEP A N 1 HETATM 1551 C CA . SEP A 1 198 ? -41.544 -3.820 23.084 1.00 43.06 ? 198 SEP A CA 1 HETATM 1552 C CB . SEP A 1 198 ? -41.261 -4.087 24.566 1.00 43.32 ? 198 SEP A CB 1 HETATM 1553 O OG . SEP A 1 198 ? -41.565 -5.457 24.909 1.00 48.92 ? 198 SEP A OG 1 HETATM 1554 C C . SEP A 1 198 ? -40.947 -2.485 22.624 1.00 43.04 ? 198 SEP A C 1 HETATM 1555 O O . SEP A 1 198 ? -41.645 -1.600 22.102 1.00 43.20 ? 198 SEP A O 1 HETATM 1556 P P . SEP A 1 198 ? -40.246 -6.406 25.190 1.00 52.53 ? 198 SEP A P 1 HETATM 1557 O O1P . SEP A 1 198 ? -39.124 -5.400 25.781 1.00 54.52 ? 198 SEP A O1P 1 HETATM 1558 O O2P . SEP A 1 198 ? -39.790 -7.059 23.788 1.00 53.01 ? 198 SEP A O2P 1 HETATM 1559 O O3P . SEP A 1 198 ? -40.386 -7.631 26.227 1.00 49.08 ? 198 SEP A O3P 1 ATOM 1560 N N . LEU A 1 199 ? -39.632 -2.380 22.766 1.00 42.80 ? 199 LEU A N 1 ATOM 1561 C CA . LEU A 1 199 ? -38.908 -1.198 22.368 1.00 42.23 ? 199 LEU A CA 1 ATOM 1562 C C . LEU A 1 199 ? -38.939 -1.005 20.872 1.00 41.88 ? 199 LEU A C 1 ATOM 1563 O O . LEU A 1 199 ? -38.921 0.124 20.414 1.00 42.60 ? 199 LEU A O 1 ATOM 1564 C CB . LEU A 1 199 ? -37.470 -1.252 22.906 1.00 42.18 ? 199 LEU A CB 1 ATOM 1565 C CG . LEU A 1 199 ? -36.450 -0.130 22.664 1.00 41.59 ? 199 LEU A CG 1 ATOM 1566 C CD1 . LEU A 1 199 ? -37.040 1.259 22.825 1.00 37.93 ? 199 LEU A CD1 1 ATOM 1567 C CD2 . LEU A 1 199 ? -35.215 -0.334 23.596 1.00 39.93 ? 199 LEU A CD2 1 ATOM 1568 N N . ALA A 1 200 ? -39.022 -2.093 20.114 1.00 41.56 ? 200 ALA A N 1 ATOM 1569 C CA . ALA A 1 200 ? -38.973 -2.028 18.647 1.00 41.43 ? 200 ALA A CA 1 ATOM 1570 C C . ALA A 1 200 ? -40.216 -1.391 18.053 1.00 41.73 ? 200 ALA A C 1 ATOM 1571 O O . ALA A 1 200 ? -40.159 -0.729 17.004 1.00 41.71 ? 200 ALA A O 1 ATOM 1572 C CB . ALA A 1 200 ? -38.759 -3.424 18.052 1.00 41.52 ? 200 ALA A CB 1 ATOM 1573 N N . SER A 1 201 ? -41.341 -1.613 18.725 1.00 42.06 ? 201 SER A N 1 ATOM 1574 C CA . SER A 1 201 ? -42.625 -1.040 18.321 1.00 42.51 ? 201 SER A CA 1 ATOM 1575 C C . SER A 1 201 ? -42.725 0.424 18.765 1.00 42.83 ? 201 SER A C 1 ATOM 1576 O O . SER A 1 201 ? -43.091 1.297 17.975 1.00 42.39 ? 201 SER A O 1 ATOM 1577 C CB . SER A 1 201 ? -43.767 -1.845 18.923 1.00 41.96 ? 201 SER A CB 1 ATOM 1578 O OG . SER A 1 201 ? -44.598 -2.285 17.894 1.00 41.06 ? 201 SER A OG 1 ATOM 1579 N N . ARG A 1 202 ? -42.351 0.685 20.019 1.00 43.58 ? 202 ARG A N 1 ATOM 1580 C CA . ARG A 1 202 ? -42.366 2.036 20.558 1.00 44.21 ? 202 ARG A CA 1 ATOM 1581 C C . ARG A 1 202 ? -41.589 3.020 19.692 1.00 44.18 ? 202 ARG A C 1 ATOM 1582 O O . ARG A 1 202 ? -41.930 4.185 19.638 1.00 44.46 ? 202 ARG A O 1 ATOM 1583 C CB . ARG A 1 202 ? -41.876 2.039 21.993 1.00 44.66 ? 202 ARG A CB 1 ATOM 1584 C CG . ARG A 1 202 ? -42.039 3.373 22.740 1.00 46.80 ? 202 ARG A CG 1 ATOM 1585 C CD . ARG A 1 202 ? -41.022 3.433 23.857 1.00 49.83 ? 202 ARG A CD 1 ATOM 1586 N NE . ARG A 1 202 ? -41.265 4.493 24.830 1.00 53.78 ? 202 ARG A NE 1 ATOM 1587 C CZ . ARG A 1 202 ? -40.593 4.621 25.977 1.00 55.74 ? 202 ARG A CZ 1 ATOM 1588 N NH1 . ARG A 1 202 ? -39.637 3.749 26.286 1.00 55.78 ? 202 ARG A NH1 1 ATOM 1589 N NH2 . ARG A 1 202 ? -40.869 5.616 26.823 1.00 56.77 ? 202 ARG A NH2 1 ATOM 1590 N N . LEU A 1 203 ? -40.578 2.542 18.974 1.00 44.67 ? 203 LEU A N 1 ATOM 1591 C CA . LEU A 1 203 ? -39.769 3.401 18.091 1.00 44.44 ? 203 LEU A CA 1 ATOM 1592 C C . LEU A 1 203 ? -40.371 3.574 16.706 1.00 45.29 ? 203 LEU A C 1 ATOM 1593 O O . LEU A 1 203 ? -39.871 4.358 15.888 1.00 44.96 ? 203 LEU A O 1 ATOM 1594 C CB . LEU A 1 203 ? -38.381 2.809 17.909 1.00 43.95 ? 203 LEU A CB 1 ATOM 1595 C CG . LEU A 1 203 ? -37.531 2.600 19.146 1.00 42.64 ? 203 LEU A CG 1 ATOM 1596 C CD1 . LEU A 1 203 ? -36.441 1.669 18.721 1.00 42.22 ? 203 LEU A CD1 1 ATOM 1597 C CD2 . LEU A 1 203 ? -36.986 3.925 19.649 1.00 40.36 ? 203 LEU A CD2 1 ATOM 1598 N N . ARG A 1 204 ? -41.419 2.819 16.414 1.00 45.91 ? 204 ARG A N 1 ATOM 1599 C CA . ARG A 1 204 ? -41.959 2.859 15.072 1.00 46.48 ? 204 ARG A CA 1 ATOM 1600 C C . ARG A 1 204 ? -43.051 3.892 14.997 1.00 47.14 ? 204 ARG A C 1 ATOM 1601 O O . ARG A 1 204 ? -43.809 4.093 15.963 1.00 46.44 ? 204 ARG A O 1 ATOM 1602 C CB . ARG A 1 204 ? -42.492 1.502 14.642 1.00 46.56 ? 204 ARG A CB 1 ATOM 1603 C CG . ARG A 1 204 ? -41.445 0.572 14.045 1.00 46.51 ? 204 ARG A CG 1 ATOM 1604 C CD . ARG A 1 204 ? -42.008 -0.833 13.953 1.00 44.92 ? 204 ARG A CD 1 ATOM 1605 N NE . ARG A 1 204 ? -42.822 -0.998 12.755 1.00 47.40 ? 204 ARG A NE 1 ATOM 1606 C CZ . ARG A 1 204 ? -43.255 -2.168 12.289 1.00 47.48 ? 204 ARG A CZ 1 ATOM 1607 N NH1 . ARG A 1 204 ? -42.954 -3.301 12.918 1.00 46.26 ? 204 ARG A NH1 1 ATOM 1608 N NH2 . ARG A 1 204 ? -43.979 -2.203 11.183 1.00 46.75 ? 204 ARG A NH2 1 ATOM 1609 N N . ASN A 1 205 ? -43.139 4.539 13.836 1.00 48.28 ? 205 ASN A N 1 ATOM 1610 C CA . ASN A 1 205 ? -44.204 5.487 13.531 1.00 49.98 ? 205 ASN A CA 1 ATOM 1611 C C . ASN A 1 205 ? -45.418 4.754 12.971 1.00 50.96 ? 205 ASN A C 1 ATOM 1612 O O . ASN A 1 205 ? -45.605 4.658 11.758 1.00 50.79 ? 205 ASN A O 1 ATOM 1613 C CB . ASN A 1 205 ? -43.717 6.543 12.539 1.00 50.04 ? 205 ASN A CB 1 ATOM 1614 C CG . ASN A 1 205 ? -44.764 7.603 12.257 1.00 51.78 ? 205 ASN A CG 1 ATOM 1615 O OD1 . ASN A 1 205 ? -45.870 7.559 12.796 1.00 52.50 ? 205 ASN A OD1 1 ATOM 1616 N ND2 . ASN A 1 205 ? -44.419 8.564 11.407 1.00 54.03 ? 205 ASN A ND2 1 ATOM 1617 N N . LEU A 1 206 ? -46.231 4.236 13.881 1.00 52.35 ? 206 LEU A N 1 ATOM 1618 C CA . LEU A 1 206 ? -47.385 3.408 13.563 1.00 53.86 ? 206 LEU A CA 1 ATOM 1619 C C . LEU A 1 206 ? -48.481 4.234 12.863 1.00 55.28 ? 206 LEU A C 1 ATOM 1620 O O . LEU A 1 206 ? -48.942 3.872 11.771 1.00 55.16 ? 206 LEU A O 1 ATOM 1621 C CB . LEU A 1 206 ? -47.888 2.730 14.831 1.00 53.68 ? 206 LEU A CB 1 ATOM 1622 C CG . LEU A 1 206 ? -46.856 1.798 15.469 1.00 53.25 ? 206 LEU A CG 1 ATOM 1623 C CD1 . LEU A 1 206 ? -47.061 1.669 16.981 1.00 53.52 ? 206 LEU A CD1 1 ATOM 1624 C CD2 . LEU A 1 206 ? -46.871 0.445 14.800 1.00 51.39 ? 206 LEU A CD2 1 ATOM 1625 N N . SER A 1 207 ? -48.588 5.491 13.259 1.00 56.94 ? 207 SER A N 1 ATOM 1626 C CA . SER A 1 207 ? -49.563 6.423 12.735 1.00 58.33 ? 207 SER A CA 1 ATOM 1627 C C . SER A 1 207 ? -49.213 6.926 11.346 1.00 59.24 ? 207 SER A C 1 ATOM 1628 O O . SER A 1 207 ? -48.808 8.023 11.071 1.00 59.60 ? 207 SER A O 1 ATOM 1629 C CB . SER A 1 207 ? -49.651 7.625 13.664 1.00 58.51 ? 207 SER A CB 1 ATOM 1630 O OG . SER A 1 207 ? -49.899 7.254 15.000 1.00 58.79 ? 207 SER A OG 1 ATOM 1631 N N . SER A 1 208 ? -49.339 5.958 10.508 1.00 60.19 ? 208 SER A N 1 ATOM 1632 C CA . SER A 1 208 ? -49.656 5.855 9.073 1.00 60.75 ? 208 SER A CA 1 ATOM 1633 C C . SER A 1 208 ? -48.826 4.629 8.649 1.00 60.89 ? 208 SER A C 1 ATOM 1634 O O . SER A 1 208 ? -47.660 4.516 8.998 1.00 61.03 ? 208 SER A O 1 ATOM 1635 C CB . SER A 1 208 ? -48.983 7.173 8.661 1.00 60.70 ? 208 SER A CB 1 ATOM 1636 O OG . SER A 1 208 ? -47.577 7.112 8.851 1.00 61.00 ? 208 SER A OG 1 ATOM 1637 N N . PRO A 1 209 ? -49.240 3.874 7.670 1.00 61.09 ? 209 PRO A N 1 ATOM 1638 C CA . PRO A 1 209 ? -48.370 2.792 7.211 1.00 60.61 ? 209 PRO A CA 1 ATOM 1639 C C . PRO A 1 209 ? -47.427 3.199 6.069 1.00 60.35 ? 209 PRO A C 1 ATOM 1640 O O . PRO A 1 209 ? -47.647 2.792 4.926 1.00 60.72 ? 209 PRO A O 1 ATOM 1641 C CB . PRO A 1 209 ? -49.380 1.763 6.716 1.00 61.02 ? 209 PRO A CB 1 ATOM 1642 C CG . PRO A 1 209 ? -50.519 2.628 6.118 1.00 61.43 ? 209 PRO A CG 1 ATOM 1643 C CD . PRO A 1 209 ? -50.518 3.932 6.922 1.00 61.04 ? 209 PRO A CD 1 ATOM 1644 N N . LEU A 1 210 ? -46.403 4.005 6.362 1.00 59.54 ? 210 LEU A N 1 ATOM 1645 C CA . LEU A 1 210 ? -45.332 4.270 5.378 1.00 58.49 ? 210 LEU A CA 1 ATOM 1646 C C . LEU A 1 210 ? -43.990 3.632 5.771 1.00 57.40 ? 210 LEU A C 1 ATOM 1647 O O . LEU A 1 210 ? -42.947 3.962 5.186 1.00 57.41 ? 210 LEU A O 1 ATOM 1648 C CB . LEU A 1 210 ? -45.127 5.784 5.118 1.00 59.03 ? 210 LEU A CB 1 ATOM 1649 C CG . LEU A 1 210 ? -45.854 6.603 4.032 1.00 59.04 ? 210 LEU A CG 1 ATOM 1650 C CD1 . LEU A 1 210 ? -45.422 8.063 4.140 1.00 60.13 ? 210 LEU A CD1 1 ATOM 1651 C CD2 . LEU A 1 210 ? -45.601 6.091 2.621 1.00 59.50 ? 210 LEU A CD2 1 ATOM 1652 N N . GLY A 1 211 ? -44.013 2.735 6.755 1.00 56.07 ? 211 GLY A N 1 ATOM 1653 C CA . GLY A 1 211 ? -42.790 2.044 7.177 1.00 55.01 ? 211 GLY A CA 1 ATOM 1654 C C . GLY A 1 211 ? -41.704 3.003 7.663 1.00 54.09 ? 211 GLY A C 1 ATOM 1655 O O . GLY A 1 211 ? -40.505 2.787 7.446 1.00 53.56 ? 211 GLY A O 1 ATOM 1656 N N . LEU A 1 212 ? -42.146 4.067 8.327 1.00 52.84 ? 212 LEU A N 1 ATOM 1657 C CA . LEU A 1 212 ? -41.272 5.094 8.836 1.00 51.38 ? 212 LEU A CA 1 ATOM 1658 C C . LEU A 1 212 ? -40.934 4.816 10.282 1.00 50.30 ? 212 LEU A C 1 ATOM 1659 O O . LEU A 1 212 ? -41.728 4.239 11.035 1.00 49.61 ? 212 LEU A O 1 ATOM 1660 C CB . LEU A 1 212 ? -41.948 6.461 8.742 1.00 51.38 ? 212 LEU A CB 1 ATOM 1661 C CG . LEU A 1 212 ? -42.161 7.020 7.342 1.00 51.60 ? 212 LEU A CG 1 ATOM 1662 C CD1 . LEU A 1 212 ? -42.998 8.270 7.444 1.00 53.16 ? 212 LEU A CD1 1 ATOM 1663 C CD2 . LEU A 1 212 ? -40.833 7.302 6.635 1.00 51.65 ? 212 LEU A CD2 1 ATOM 1664 N N . MET A 1 213 ? -39.738 5.246 10.660 1.00 48.75 ? 213 MET A N 1 ATOM 1665 C CA . MET A 1 213 ? -39.341 5.209 12.049 1.00 47.22 ? 213 MET A CA 1 ATOM 1666 C C . MET A 1 213 ? -39.772 6.503 12.737 1.00 46.50 ? 213 MET A C 1 ATOM 1667 O O . MET A 1 213 ? -39.589 7.589 12.176 1.00 45.90 ? 213 MET A O 1 ATOM 1668 C CB . MET A 1 213 ? -37.837 4.984 12.128 1.00 46.55 ? 213 MET A CB 1 ATOM 1669 C CG . MET A 1 213 ? -37.414 3.552 11.785 1.00 43.77 ? 213 MET A CG 1 ATOM 1670 S SD . MET A 1 213 ? -37.824 2.354 13.062 1.00 37.45 ? 213 MET A SD 1 ATOM 1671 C CE . MET A 1 213 ? -36.513 2.638 14.249 1.00 39.43 ? 213 MET A CE 1 ATOM 1672 N N . ALA A 1 214 ? -40.370 6.358 13.923 1.00 46.24 ? 214 ALA A N 1 ATOM 1673 C CA . ALA A 1 214 ? -40.865 7.479 14.777 1.00 46.75 ? 214 ALA A CA 1 ATOM 1674 C C . ALA A 1 214 ? -39.865 8.594 15.006 1.00 46.77 ? 214 ALA A C 1 ATOM 1675 O O . ALA A 1 214 ? -38.926 8.391 15.738 1.00 47.74 ? 214 ALA A O 1 ATOM 1676 C CB . ALA A 1 214 ? -41.325 6.945 16.144 1.00 45.72 ? 214 ALA A CB 1 ATOM 1677 N N . VAL A 1 215 ? -40.076 9.769 14.412 1.00 47.74 ? 215 VAL A N 1 ATOM 1678 C CA . VAL A 1 215 ? -39.128 10.910 14.533 1.00 47.84 ? 215 VAL A CA 1 ATOM 1679 C C . VAL A 1 215 ? -39.489 11.941 15.639 1.00 48.31 ? 215 VAL A C 1 ATOM 1680 O O . VAL A 1 215 ? -40.514 11.820 16.321 1.00 48.10 ? 215 VAL A O 1 ATOM 1681 C CB . VAL A 1 215 ? -38.870 11.641 13.173 1.00 47.98 ? 215 VAL A CB 1 ATOM 1682 C CG1 . VAL A 1 215 ? -38.525 10.654 12.030 1.00 47.02 ? 215 VAL A CG1 1 ATOM 1683 C CG2 . VAL A 1 215 ? -40.033 12.538 12.801 1.00 48.05 ? 215 VAL A CG2 1 ATOM 1684 N N . ASN A 1 216 ? -38.624 12.938 15.830 1.00 48.55 ? 216 ASN A N 1 ATOM 1685 C CA . ASN A 1 216 ? -38.822 13.934 16.888 1.00 48.96 ? 216 ASN A CA 1 ATOM 1686 C C . ASN A 1 216 ? -39.853 14.996 16.474 1.00 48.85 ? 216 ASN A C 1 ATOM 1687 O O . ASN A 1 216 ? -39.741 15.591 15.402 1.00 48.50 ? 216 ASN A O 1 ATOM 1688 C CB . ASN A 1 216 ? -37.478 14.566 17.301 1.00 48.86 ? 216 ASN A CB 1 ATOM 1689 C CG . ASN A 1 216 ? -37.608 15.541 18.468 1.00 48.86 ? 216 ASN A CG 1 ATOM 1690 O OD1 . ASN A 1 216 ? -37.998 16.701 18.282 1.00 48.50 ? 216 ASN A OD1 1 ATOM 1691 N ND2 . ASN A 1 216 ? -37.243 15.085 19.672 1.00 48.11 ? 216 ASN A ND2 1 ATOM 1692 N N . GLN A 1 217 ? -40.841 15.222 17.335 1.00 48.99 ? 217 GLN A N 1 ATOM 1693 C CA . GLN A 1 217 ? -41.930 16.147 17.024 1.00 49.95 ? 217 GLN A CA 1 ATOM 1694 C C . GLN A 1 217 ? -41.688 17.579 17.520 1.00 50.41 ? 217 GLN A C 1 ATOM 1695 O O . GLN A 1 217 ? -42.330 18.518 17.029 1.00 50.84 ? 217 GLN A O 1 ATOM 1696 C CB . GLN A 1 217 ? -43.292 15.626 17.544 1.00 50.07 ? 217 GLN A CB 1 ATOM 1697 C CG . GLN A 1 217 ? -43.862 14.347 16.866 1.00 50.81 ? 217 GLN A CG 1 ATOM 1698 C CD . GLN A 1 217 ? -43.375 14.126 15.431 1.00 52.25 ? 217 GLN A CD 1 ATOM 1699 O OE1 . GLN A 1 217 ? -43.715 14.878 14.514 1.00 53.42 ? 217 GLN A OE1 1 ATOM 1700 N NE2 . GLN A 1 217 ? -42.572 13.084 15.238 1.00 52.22 ? 217 GLN A NE2 1 ATOM 1701 N N . GLU A 1 218 ? -40.766 17.750 18.473 1.00 50.34 ? 218 GLU A N 1 ATOM 1702 C CA . GLU A 1 218 ? -40.509 19.068 19.078 1.00 49.87 ? 218 GLU A CA 1 ATOM 1703 C C . GLU A 1 218 ? -39.346 19.852 18.467 1.00 48.75 ? 218 GLU A C 1 ATOM 1704 O O . GLU A 1 218 ? -39.232 21.055 18.694 1.00 49.21 ? 218 GLU A O 1 ATOM 1705 C CB . GLU A 1 218 ? -40.342 18.954 20.596 1.00 50.43 ? 218 GLU A CB 1 ATOM 1706 C CG . GLU A 1 218 ? -41.365 18.035 21.271 1.00 52.74 ? 218 GLU A CG 1 ATOM 1707 C CD . GLU A 1 218 ? -41.225 18.029 22.788 1.00 57.62 ? 218 GLU A CD 1 ATOM 1708 O OE1 . GLU A 1 218 ? -40.089 18.219 23.274 1.00 57.67 ? 218 GLU A OE1 1 ATOM 1709 O OE2 . GLU A 1 218 ? -42.249 17.837 23.501 1.00 60.00 ? 218 GLU A OE2 1 ATOM 1710 N N . ALA A 1 219 ? -38.494 19.202 17.687 1.00 47.26 ? 219 ALA A N 1 ATOM 1711 C CA . ALA A 1 219 ? -37.389 19.928 17.077 1.00 46.26 ? 219 ALA A CA 1 ATOM 1712 C C . ALA A 1 219 ? -36.970 19.318 15.766 1.00 45.69 ? 219 ALA A C 1 ATOM 1713 O O . ALA A 1 219 ? -37.299 18.181 15.478 1.00 45.79 ? 219 ALA A O 1 ATOM 1714 C CB . ALA A 1 219 ? -36.204 20.013 18.035 1.00 46.67 ? 219 ALA A CB 1 ATOM 1715 N N . TRP A 1 220 ? -36.246 20.073 14.963 1.00 45.26 ? 220 TRP A N 1 ATOM 1716 C CA . TRP A 1 220 ? -35.834 19.582 13.668 1.00 45.89 ? 220 TRP A CA 1 ATOM 1717 C C . TRP A 1 220 ? -34.446 20.096 13.370 1.00 45.37 ? 220 TRP A C 1 ATOM 1718 O O . TRP A 1 220 ? -33.944 20.942 14.100 1.00 45.42 ? 220 TRP A O 1 ATOM 1719 C CB . TRP A 1 220 ? -36.841 20.004 12.586 1.00 46.64 ? 220 TRP A CB 1 ATOM 1720 C CG . TRP A 1 220 ? -38.208 19.391 12.796 1.00 49.80 ? 220 TRP A CG 1 ATOM 1721 C CD1 . TRP A 1 220 ? -38.633 18.160 12.367 1.00 52.53 ? 220 TRP A CD1 1 ATOM 1722 C CD2 . TRP A 1 220 ? -39.308 19.960 13.523 1.00 52.52 ? 220 TRP A CD2 1 ATOM 1723 N NE1 . TRP A 1 220 ? -39.935 17.934 12.769 1.00 53.77 ? 220 TRP A NE1 1 ATOM 1724 C CE2 . TRP A 1 220 ? -40.372 19.019 13.482 1.00 53.56 ? 220 TRP A CE2 1 ATOM 1725 C CE3 . TRP A 1 220 ? -39.502 21.174 14.199 1.00 53.05 ? 220 TRP A CE3 1 ATOM 1726 C CZ2 . TRP A 1 220 ? -41.607 19.257 14.086 1.00 54.87 ? 220 TRP A CZ2 1 ATOM 1727 C CZ3 . TRP A 1 220 ? -40.725 21.407 14.809 1.00 55.41 ? 220 TRP A CZ3 1 ATOM 1728 C CH2 . TRP A 1 220 ? -41.765 20.450 14.750 1.00 56.36 ? 220 TRP A CH2 1 ATOM 1729 N N . ASP A 1 221 ? -33.866 19.597 12.265 1.00 45.13 ? 221 ASP A N 1 ATOM 1730 C CA . ASP A 1 221 ? -32.505 19.866 11.759 1.00 44.64 ? 221 ASP A CA 1 ATOM 1731 C C . ASP A 1 221 ? -32.444 20.274 10.253 1.00 44.81 ? 221 ASP A C 1 ATOM 1732 O O . ASP A 1 221 ? -31.806 19.744 9.405 1.00 43.92 ? 221 ASP A O 1 ATOM 1733 C CB . ASP A 1 221 ? -31.578 18.709 12.086 1.00 44.10 ? 221 ASP A CB 1 ATOM 1734 C CG . ASP A 1 221 ? -30.164 19.030 11.853 1.00 43.96 ? 221 ASP A CG 1 ATOM 1735 O OD1 . ASP A 1 221 ? -29.799 20.185 11.885 1.00 44.51 ? 221 ASP A OD1 1 ATOM 1736 O OD2 . ASP A 1 221 ? -29.390 18.140 11.619 1.00 43.42 ? 221 ASP A OD2 1 ATOM 1737 N N . HIS A 1 222 ? -33.065 21.438 10.188 1.00 45.32 ? 222 HIS A N 1 ATOM 1738 C CA . HIS A 1 222 ? -33.301 22.184 9.023 1.00 45.84 ? 222 HIS A CA 1 ATOM 1739 C C . HIS A 1 222 ? -34.096 21.413 8.004 1.00 45.02 ? 222 HIS A C 1 ATOM 1740 O O . HIS A 1 222 ? -33.616 21.295 6.938 1.00 44.93 ? 222 HIS A O 1 ATOM 1741 C CB . HIS A 1 222 ? -31.940 22.517 8.419 1.00 47.03 ? 222 HIS A CB 1 ATOM 1742 C CG . HIS A 1 222 ? -30.943 23.126 9.370 1.00 49.27 ? 222 HIS A CG 1 ATOM 1743 N ND1 . HIS A 1 222 ? -30.190 22.386 10.247 1.00 50.25 ? 222 HIS A ND1 1 ATOM 1744 C CD2 . HIS A 1 222 ? -30.510 24.392 9.504 1.00 49.31 ? 222 HIS A CD2 1 ATOM 1745 C CE1 . HIS A 1 222 ? -29.373 23.174 10.909 1.00 51.20 ? 222 HIS A CE1 1 ATOM 1746 N NE2 . HIS A 1 222 ? -29.544 24.395 10.472 1.00 50.79 ? 222 HIS A NE2 1 ATOM 1747 N N . GLY A 1 223 ? -35.251 20.815 8.290 1.00 44.65 ? 223 GLY A N 1 ATOM 1748 C CA . GLY A 1 223 ? -35.785 19.976 7.237 1.00 44.75 ? 223 GLY A CA 1 ATOM 1749 C C . GLY A 1 223 ? -35.372 18.530 7.371 1.00 44.95 ? 223 GLY A C 1 ATOM 1750 O O . GLY A 1 223 ? -35.885 17.681 6.638 1.00 46.02 ? 223 GLY A O 1 ATOM 1751 N N . LEU A 1 224 ? -34.426 18.239 8.266 1.00 44.04 ? 224 LEU A N 1 ATOM 1752 C CA . LEU A 1 224 ? -34.065 16.853 8.553 1.00 43.09 ? 224 LEU A CA 1 ATOM 1753 C C . LEU A 1 224 ? -34.433 16.467 9.989 1.00 42.42 ? 224 LEU A C 1 ATOM 1754 O O . LEU A 1 224 ? -34.548 17.320 10.871 1.00 42.83 ? 224 LEU A O 1 ATOM 1755 C CB . LEU A 1 224 ? -32.596 16.578 8.246 1.00 43.27 ? 224 LEU A CB 1 ATOM 1756 C CG . LEU A 1 224 ? -31.975 17.089 6.932 1.00 42.51 ? 224 LEU A CG 1 ATOM 1757 C CD1 . LEU A 1 224 ? -30.504 16.957 7.007 1.00 41.17 ? 224 LEU A CD1 1 ATOM 1758 C CD2 . LEU A 1 224 ? -32.485 16.368 5.694 1.00 43.21 ? 224 LEU A CD2 1 ATOM 1759 N N . ALA A 1 225 ? -34.626 15.175 10.203 1.00 41.55 ? 225 ALA A N 1 ATOM 1760 C CA . ALA A 1 225 ? -35.168 14.642 11.445 1.00 40.65 ? 225 ALA A CA 1 ATOM 1761 C C . ALA A 1 225 ? -34.153 14.407 12.546 1.00 39.96 ? 225 ALA A C 1 ATOM 1762 O O . ALA A 1 225 ? -32.960 14.339 12.293 1.00 39.00 ? 225 ALA A O 1 ATOM 1763 C CB . ALA A 1 225 ? -35.928 13.332 11.160 1.00 40.88 ? 225 ALA A CB 1 ATOM 1764 N N . TYR A 1 226 ? -34.684 14.263 13.761 1.00 39.75 ? 226 TYR A N 1 ATOM 1765 C CA . TYR A 1 226 ? -33.957 13.850 14.950 1.00 40.26 ? 226 TYR A CA 1 ATOM 1766 C C . TYR A 1 226 ? -34.561 12.569 15.545 1.00 41.04 ? 226 TYR A C 1 ATOM 1767 O O . TYR A 1 226 ? -35.743 12.272 15.316 1.00 42.12 ? 226 TYR A O 1 ATOM 1768 C CB . TYR A 1 226 ? -34.046 14.947 16.015 1.00 40.13 ? 226 TYR A CB 1 ATOM 1769 C CG . TYR A 1 226 ? -33.100 16.119 15.824 1.00 39.11 ? 226 TYR A CG 1 ATOM 1770 C CD1 . TYR A 1 226 ? -33.566 17.441 15.851 1.00 38.52 ? 226 TYR A CD1 1 ATOM 1771 C CD2 . TYR A 1 226 ? -31.748 15.907 15.626 1.00 38.37 ? 226 TYR A CD2 1 ATOM 1772 C CE1 . TYR A 1 226 ? -32.695 18.511 15.662 1.00 39.16 ? 226 TYR A CE1 1 ATOM 1773 C CE2 . TYR A 1 226 ? -30.881 16.951 15.452 1.00 38.15 ? 226 TYR A CE2 1 ATOM 1774 C CZ . TYR A 1 226 ? -31.344 18.252 15.471 1.00 39.99 ? 226 TYR A CZ 1 ATOM 1775 O OH . TYR A 1 226 ? -30.427 19.276 15.292 1.00 41.59 ? 226 TYR A OH 1 ATOM 1776 N N . LEU A 1 227 ? -33.797 11.824 16.339 1.00 41.19 ? 227 LEU A N 1 ATOM 1777 C CA . LEU A 1 227 ? -34.412 10.748 17.121 1.00 42.03 ? 227 LEU A CA 1 ATOM 1778 C C . LEU A 1 227 ? -35.389 11.389 18.105 1.00 41.98 ? 227 LEU A C 1 ATOM 1779 O O . LEU A 1 227 ? -35.184 12.520 18.498 1.00 42.38 ? 227 LEU A O 1 ATOM 1780 C CB . LEU A 1 227 ? -33.365 9.900 17.869 1.00 42.12 ? 227 LEU A CB 1 ATOM 1781 C CG . LEU A 1 227 ? -32.662 8.657 17.264 1.00 42.83 ? 227 LEU A CG 1 ATOM 1782 C CD1 . LEU A 1 227 ? -31.744 8.053 18.299 1.00 41.88 ? 227 LEU A CD1 1 ATOM 1783 C CD2 . LEU A 1 227 ? -33.619 7.563 16.771 1.00 45.58 ? 227 LEU A CD2 1 ATOM 1784 N N . PRO A 1 228 ? -36.468 10.681 18.486 1.00 42.41 ? 228 PRO A N 1 ATOM 1785 C CA . PRO A 1 228 ? -37.416 11.226 19.477 1.00 42.55 ? 228 PRO A CA 1 ATOM 1786 C C . PRO A 1 228 ? -36.781 11.298 20.847 1.00 43.38 ? 228 PRO A C 1 ATOM 1787 O O . PRO A 1 228 ? -35.835 10.556 21.105 1.00 44.25 ? 228 PRO A O 1 ATOM 1788 C CB . PRO A 1 228 ? -38.541 10.198 19.496 1.00 42.50 ? 228 PRO A CB 1 ATOM 1789 C CG . PRO A 1 228 ? -38.012 8.992 18.785 1.00 41.93 ? 228 PRO A CG 1 ATOM 1790 C CD . PRO A 1 228 ? -36.976 9.456 17.846 1.00 41.95 ? 228 PRO A CD 1 ATOM 1791 N N . PHE A 1 229 ? -37.274 12.163 21.725 1.00 43.58 ? 229 PHE A N 1 ATOM 1792 C CA . PHE A 1 229 ? -36.705 12.233 23.065 1.00 44.05 ? 229 PHE A CA 1 ATOM 1793 C C . PHE A 1 229 ? -37.200 11.071 23.886 1.00 45.07 ? 229 PHE A C 1 ATOM 1794 O O . PHE A 1 229 ? -38.373 10.724 23.842 1.00 45.26 ? 229 PHE A O 1 ATOM 1795 C CB . PHE A 1 229 ? -37.048 13.549 23.794 1.00 43.51 ? 229 PHE A CB 1 ATOM 1796 C CG . PHE A 1 229 ? -36.500 14.802 23.129 1.00 43.52 ? 229 PHE A CG 1 ATOM 1797 C CD1 . PHE A 1 229 ? -35.167 14.879 22.718 1.00 41.57 ? 229 PHE A CD1 1 ATOM 1798 C CD2 . PHE A 1 229 ? -37.322 15.920 22.944 1.00 44.41 ? 229 PHE A CD2 1 ATOM 1799 C CE1 . PHE A 1 229 ? -34.666 16.019 22.121 1.00 42.00 ? 229 PHE A CE1 1 ATOM 1800 C CE2 . PHE A 1 229 ? -36.832 17.090 22.347 1.00 44.22 ? 229 PHE A CE2 1 ATOM 1801 C CZ . PHE A 1 229 ? -35.491 17.135 21.932 1.00 44.98 ? 229 PHE A CZ 1 ATOM 1802 N N . ASN A 1 230 ? -36.301 10.447 24.631 1.00 46.30 ? 230 ASN A N 1 ATOM 1803 C CA . ASN A 1 230 ? -36.738 9.598 25.709 1.00 47.39 ? 230 ASN A CA 1 ATOM 1804 C C . ASN A 1 230 ? -37.259 10.513 26.801 1.00 48.30 ? 230 ASN A C 1 ATOM 1805 O O . ASN A 1 230 ? -36.547 11.410 27.252 1.00 48.61 ? 230 ASN A O 1 ATOM 1806 C CB . ASN A 1 230 ? -35.587 8.769 26.242 1.00 47.28 ? 230 ASN A CB 1 ATOM 1807 C CG . ASN A 1 230 ? -35.955 8.039 27.495 1.00 47.75 ? 230 ASN A CG 1 ATOM 1808 O OD1 . ASN A 1 230 ? -36.929 8.394 28.160 1.00 48.99 ? 230 ASN A OD1 1 ATOM 1809 N ND2 . ASN A 1 230 ? -35.179 7.016 27.844 1.00 47.32 ? 230 ASN A ND2 1 ATOM 1810 N N . ASN A 1 231 ? -38.493 10.286 27.240 1.00 49.42 ? 231 ASN A N 1 ATOM 1811 C CA . ASN A 1 231 ? -39.103 11.183 28.232 1.00 49.77 ? 231 ASN A CA 1 ATOM 1812 C C . ASN A 1 231 ? -39.009 10.759 29.680 1.00 50.20 ? 231 ASN A C 1 ATOM 1813 O O . ASN A 1 231 ? -39.622 11.376 30.541 1.00 50.76 ? 231 ASN A O 1 ATOM 1814 C CB . ASN A 1 231 ? -40.544 11.522 27.859 1.00 49.37 ? 231 ASN A CB 1 ATOM 1815 C CG . ASN A 1 231 ? -40.617 12.495 26.721 1.00 48.61 ? 231 ASN A CG 1 ATOM 1816 O OD1 . ASN A 1 231 ? -41.253 12.227 25.699 1.00 48.12 ? 231 ASN A OD1 1 ATOM 1817 N ND2 . ASN A 1 231 ? -39.936 13.626 26.868 1.00 47.58 ? 231 ASN A ND2 1 ATOM 1818 N N . LYS A 1 232 ? -38.231 9.720 29.949 1.00 50.88 ? 232 LYS A N 1 ATOM 1819 C CA . LYS A 1 232 ? -38.040 9.246 31.312 1.00 51.34 ? 232 LYS A CA 1 ATOM 1820 C C . LYS A 1 232 ? -37.259 10.242 32.160 1.00 51.44 ? 232 LYS A C 1 ATOM 1821 O O . LYS A 1 232 ? -36.070 10.481 31.914 1.00 52.13 ? 232 LYS A O 1 ATOM 1822 C CB . LYS A 1 232 ? -37.339 7.881 31.319 1.00 51.54 ? 232 LYS A CB 1 ATOM 1823 C CG . LYS A 1 232 ? -37.111 7.276 32.709 1.00 52.39 ? 232 LYS A CG 1 ATOM 1824 C CD . LYS A 1 232 ? -38.426 7.103 33.493 1.00 55.11 ? 232 LYS A CD 1 ATOM 1825 C CE . LYS A 1 232 ? -38.229 6.298 34.781 1.00 54.79 ? 232 LYS A CE 1 ATOM 1826 N NZ . LYS A 1 232 ? -37.302 6.948 35.749 1.00 53.75 ? 232 LYS A NZ 1 ATOM 1827 N N . LYS A 1 233 ? -37.946 10.833 33.140 1.00 51.04 ? 233 LYS A N 1 ATOM 1828 C CA . LYS A 1 233 ? -37.307 11.600 34.208 1.00 50.24 ? 233 LYS A CA 1 ATOM 1829 C C . LYS A 1 233 ? -36.906 10.631 35.328 1.00 50.02 ? 233 LYS A C 1 ATOM 1830 O O . LYS A 1 233 ? -37.605 9.648 35.570 1.00 50.46 ? 233 LYS A O 1 ATOM 1831 C CB . LYS A 1 233 ? -38.266 12.659 34.767 1.00 50.55 ? 233 LYS A CB 1 ATOM 1832 C CG . LYS A 1 233 ? -38.271 13.983 34.040 1.00 49.17 ? 233 LYS A CG 1 ATOM 1833 C CD . LYS A 1 233 ? -39.086 13.899 32.785 1.00 49.26 ? 233 LYS A CD 1 ATOM 1834 C CE . LYS A 1 233 ? -38.926 15.165 31.971 1.00 49.50 ? 233 LYS A CE 1 ATOM 1835 N NZ . LYS A 1 233 ? -39.112 14.889 30.526 1.00 50.06 ? 233 LYS A NZ 1 ATOM 1836 N N . PRO A 1 234 ? -35.770 10.883 36.003 1.00 49.50 ? 234 PRO A N 1 ATOM 1837 C CA . PRO A 1 234 ? -34.832 11.953 35.715 1.00 48.77 ? 234 PRO A CA 1 ATOM 1838 C C . PRO A 1 234 ? -33.989 11.581 34.498 1.00 48.20 ? 234 PRO A C 1 ATOM 1839 O O . PRO A 1 234 ? -34.004 10.425 34.024 1.00 48.56 ? 234 PRO A O 1 ATOM 1840 C CB . PRO A 1 234 ? -33.983 12.018 36.976 1.00 48.92 ? 234 PRO A CB 1 ATOM 1841 C CG . PRO A 1 234 ? -33.943 10.602 37.470 1.00 49.22 ? 234 PRO A CG 1 ATOM 1842 C CD . PRO A 1 234 ? -35.254 9.965 37.041 1.00 49.69 ? 234 PRO A CD 1 ATOM 1843 N N . SER A 1 235 ? -33.283 12.562 33.977 1.00 46.72 ? 235 SER A N 1 ATOM 1844 C CA . SER A 1 235 ? -32.669 12.403 32.690 1.00 45.40 ? 235 SER A CA 1 ATOM 1845 C C . SER A 1 235 ? -31.243 12.923 32.725 1.00 44.55 ? 235 SER A C 1 ATOM 1846 O O . SER A 1 235 ? -30.999 14.098 33.043 1.00 44.50 ? 235 SER A O 1 ATOM 1847 C CB . SER A 1 235 ? -33.503 13.122 31.637 1.00 45.42 ? 235 SER A CB 1 ATOM 1848 O OG . SER A 1 235 ? -32.697 13.602 30.585 1.00 44.88 ? 235 SER A OG 1 ATOM 1849 N N . PRO A 1 236 ? -30.287 12.048 32.392 1.00 43.39 ? 236 PRO A N 1 ATOM 1850 C CA . PRO A 1 236 ? -28.897 12.455 32.487 1.00 42.19 ? 236 PRO A CA 1 ATOM 1851 C C . PRO A 1 236 ? -28.627 13.627 31.543 1.00 40.94 ? 236 PRO A C 1 ATOM 1852 O O . PRO A 1 236 ? -27.894 14.541 31.891 1.00 40.83 ? 236 PRO A O 1 ATOM 1853 C CB . PRO A 1 236 ? -28.124 11.195 32.079 1.00 42.22 ? 236 PRO A CB 1 ATOM 1854 C CG . PRO A 1 236 ? -29.139 10.081 32.039 1.00 43.40 ? 236 PRO A CG 1 ATOM 1855 C CD . PRO A 1 236 ? -30.445 10.736 31.742 1.00 43.44 ? 236 PRO A CD 1 ATOM 1856 N N . CYS A 1 237 ? -29.280 13.629 30.392 1.00 40.00 ? 237 CYS A N 1 ATOM 1857 C CA . CYS A 1 237 ? -29.080 14.659 29.406 1.00 39.45 ? 237 CYS A CA 1 ATOM 1858 C C . CYS A 1 237 ? -29.674 16.009 29.780 1.00 40.49 ? 237 CYS A C 1 ATOM 1859 O O . CYS A 1 237 ? -29.198 17.049 29.314 1.00 40.71 ? 237 CYS A O 1 ATOM 1860 C CB . CYS A 1 237 ? -29.633 14.206 28.074 1.00 39.17 ? 237 CYS A CB 1 ATOM 1861 S SG . CYS A 1 237 ? -28.898 12.692 27.469 1.00 35.28 ? 237 CYS A SG 1 ATOM 1862 N N . GLU A 1 238 ? -30.727 15.991 30.591 1.00 41.64 ? 238 GLU A N 1 ATOM 1863 C CA . GLU A 1 238 ? -31.332 17.209 31.114 1.00 42.40 ? 238 GLU A CA 1 ATOM 1864 C C . GLU A 1 238 ? -30.452 17.706 32.238 1.00 43.20 ? 238 GLU A C 1 ATOM 1865 O O . GLU A 1 238 ? -30.178 18.897 32.313 1.00 44.01 ? 238 GLU A O 1 ATOM 1866 C CB . GLU A 1 238 ? -32.710 16.938 31.682 1.00 42.25 ? 238 GLU A CB 1 ATOM 1867 C CG . GLU A 1 238 ? -33.828 16.876 30.672 1.00 43.10 ? 238 GLU A CG 1 ATOM 1868 C CD . GLU A 1 238 ? -35.186 16.753 31.339 1.00 42.68 ? 238 GLU A CD 1 ATOM 1869 O OE1 . GLU A 1 238 ? -35.436 15.781 32.090 1.00 41.77 ? 238 GLU A OE1 1 ATOM 1870 O OE2 . GLU A 1 238 ? -36.012 17.645 31.109 1.00 46.59 ? 238 GLU A OE2 1 ATOM 1871 N N . PHE A 1 239 ? -30.011 16.788 33.102 1.00 43.41 ? 239 PHE A N 1 ATOM 1872 C CA . PHE A 1 239 ? -29.088 17.107 34.207 1.00 44.06 ? 239 PHE A CA 1 ATOM 1873 C C . PHE A 1 239 ? -27.789 17.872 33.860 1.00 43.45 ? 239 PHE A C 1 ATOM 1874 O O . PHE A 1 239 ? -27.283 18.618 34.688 1.00 44.08 ? 239 PHE A O 1 ATOM 1875 C CB . PHE A 1 239 ? -28.709 15.835 34.980 1.00 44.16 ? 239 PHE A CB 1 ATOM 1876 C CG . PHE A 1 239 ? -27.884 16.102 36.206 1.00 47.00 ? 239 PHE A CG 1 ATOM 1877 C CD1 . PHE A 1 239 ? -28.490 16.213 37.458 1.00 49.05 ? 239 PHE A CD1 1 ATOM 1878 C CD2 . PHE A 1 239 ? -26.490 16.265 36.112 1.00 48.61 ? 239 PHE A CD2 1 ATOM 1879 C CE1 . PHE A 1 239 ? -27.712 16.468 38.608 1.00 51.01 ? 239 PHE A CE1 1 ATOM 1880 C CE2 . PHE A 1 239 ? -25.713 16.528 37.241 1.00 49.25 ? 239 PHE A CE2 1 ATOM 1881 C CZ . PHE A 1 239 ? -26.321 16.622 38.496 1.00 50.38 ? 239 PHE A CZ 1 ATOM 1882 N N . ILE A 1 240 ? -27.231 17.694 32.681 1.00 42.65 ? 240 ILE A N 1 ATOM 1883 C CA . ILE A 1 240 ? -25.978 18.355 32.354 1.00 41.84 ? 240 ILE A CA 1 ATOM 1884 C C . ILE A 1 240 ? -26.100 19.804 31.985 1.00 41.66 ? 240 ILE A C 1 ATOM 1885 O O . ILE A 1 240 ? -25.123 20.464 31.797 1.00 41.61 ? 240 ILE A O 1 ATOM 1886 C CB . ILE A 1 240 ? -25.086 17.599 31.337 1.00 41.79 ? 240 ILE A CB 1 ATOM 1887 C CG1 . ILE A 1 240 ? -25.654 17.615 29.937 1.00 40.44 ? 240 ILE A CG1 1 ATOM 1888 C CG2 . ILE A 1 240 ? -24.719 16.215 31.824 1.00 40.95 ? 240 ILE A CG2 1 ATOM 1889 C CD1 . ILE A 1 240 ? -24.874 18.411 29.049 1.00 41.38 ? 240 ILE A CD1 1 ATOM 1890 N N . ASN A 1 241 ? -27.338 20.283 31.905 1.00 40.96 ? 241 ASN A N 1 ATOM 1891 C CA . ASN A 1 241 ? -27.624 21.680 31.603 1.00 41.08 ? 241 ASN A CA 1 ATOM 1892 C C . ASN A 1 241 ? -29.095 21.996 31.854 1.00 41.13 ? 241 ASN A C 1 ATOM 1893 O O . ASN A 1 241 ? -29.910 21.972 30.932 1.00 41.55 ? 241 ASN A O 1 ATOM 1894 C CB . ASN A 1 241 ? -27.252 22.005 30.156 1.00 41.12 ? 241 ASN A CB 1 ATOM 1895 C CG . ASN A 1 241 ? -28.082 23.136 29.581 1.00 42.38 ? 241 ASN A CG 1 ATOM 1896 O OD1 . ASN A 1 241 ? -28.755 23.862 30.313 1.00 43.55 ? 241 ASN A OD1 1 ATOM 1897 N ND2 . ASN A 1 241 ? -28.038 23.291 28.263 1.00 44.73 ? 241 ASN A ND2 1 ATOM 1898 N N . THR A 1 242 ? -29.430 22.285 33.108 1.00 40.73 ? 242 THR A N 1 ATOM 1899 C CA . THR A 1 242 ? -30.806 22.512 33.496 1.00 40.70 ? 242 THR A CA 1 ATOM 1900 C C . THR A 1 242 ? -31.516 23.633 32.732 1.00 40.37 ? 242 THR A C 1 ATOM 1901 O O . THR A 1 242 ? -32.685 23.647 32.647 1.00 40.69 ? 242 THR A O 1 ATOM 1902 C CB . THR A 1 242 ? -31.041 22.490 35.015 1.00 40.67 ? 242 THR A CB 1 ATOM 1903 O OG1 . THR A 1 242 ? -30.189 23.407 35.664 1.00 40.55 ? 242 THR A OG1 1 ATOM 1904 C CG2 . THR A 1 242 ? -30.741 21.162 35.536 1.00 40.58 ? 242 THR A CG2 1 ATOM 1905 N N . THR A 1 243 ? -30.790 24.570 32.183 1.00 40.17 ? 243 THR A N 1 ATOM 1906 C CA . THR A 1 243 ? -31.437 25.637 31.414 1.00 39.85 ? 243 THR A CA 1 ATOM 1907 C C . THR A 1 243 ? -31.926 25.211 30.021 1.00 39.99 ? 243 THR A C 1 ATOM 1908 O O . THR A 1 243 ? -33.060 25.556 29.619 1.00 40.54 ? 243 THR A O 1 ATOM 1909 C CB . THR A 1 243 ? -30.543 26.850 31.237 1.00 39.65 ? 243 THR A CB 1 ATOM 1910 O OG1 . THR A 1 243 ? -30.045 27.253 32.512 1.00 39.93 ? 243 THR A OG1 1 ATOM 1911 C CG2 . THR A 1 243 ? -31.334 27.998 30.605 1.00 40.22 ? 243 THR A CG2 1 ATOM 1912 N N . ALA A 1 244 ? -31.081 24.503 29.273 1.00 38.80 ? 244 ALA A N 1 ATOM 1913 C CA . ALA A 1 244 ? -31.465 24.061 27.933 1.00 38.12 ? 244 ALA A CA 1 ATOM 1914 C C . ALA A 1 244 ? -32.474 22.906 27.990 1.00 37.81 ? 244 ALA A C 1 ATOM 1915 O O . ALA A 1 244 ? -33.285 22.732 27.082 1.00 37.81 ? 244 ALA A O 1 ATOM 1916 C CB . ALA A 1 244 ? -30.246 23.677 27.120 1.00 37.78 ? 244 ALA A CB 1 ATOM 1917 N N . ARG A 1 245 ? -32.409 22.126 29.062 1.00 37.89 ? 245 ARG A N 1 ATOM 1918 C CA . ARG A 1 245 ? -33.394 21.092 29.359 1.00 38.04 ? 245 ARG A CA 1 ATOM 1919 C C . ARG A 1 245 ? -33.723 20.204 28.156 1.00 37.58 ? 245 ARG A C 1 ATOM 1920 O O . ARG A 1 245 ? -34.907 19.984 27.841 1.00 37.81 ? 245 ARG A O 1 ATOM 1921 C CB . ARG A 1 245 ? -34.671 21.742 29.896 1.00 39.07 ? 245 ARG A CB 1 ATOM 1922 C CG . ARG A 1 245 ? -34.666 22.047 31.387 1.00 41.41 ? 245 ARG A CG 1 ATOM 1923 C CD . ARG A 1 245 ? -35.860 22.918 31.771 1.00 43.74 ? 245 ARG A CD 1 ATOM 1924 N NE . ARG A 1 245 ? -35.657 24.347 31.473 1.00 47.26 ? 245 ARG A NE 1 ATOM 1925 C CZ . ARG A 1 245 ? -35.300 25.279 32.367 1.00 46.84 ? 245 ARG A CZ 1 ATOM 1926 N NH1 . ARG A 1 245 ? -35.138 26.538 31.971 1.00 45.73 ? 245 ARG A NH1 1 ATOM 1927 N NH2 . ARG A 1 245 ? -35.096 24.962 33.653 1.00 44.86 ? 245 ARG A NH2 1 ATOM 1928 N N . VAL A 1 246 ? -32.687 19.706 27.474 1.00 36.16 ? 246 VAL A N 1 ATOM 1929 C CA . VAL A 1 246 ? -32.901 18.760 26.375 1.00 34.47 ? 246 VAL A CA 1 ATOM 1930 C C . VAL A 1 246 ? -32.658 17.343 26.869 1.00 33.36 ? 246 VAL A C 1 ATOM 1931 O O . VAL A 1 246 ? -31.627 17.070 27.450 1.00 33.06 ? 246 VAL A O 1 ATOM 1932 C CB . VAL A 1 246 ? -32.010 19.086 25.181 1.00 34.75 ? 246 VAL A CB 1 ATOM 1933 C CG1 . VAL A 1 246 ? -32.312 18.168 24.017 1.00 34.89 ? 246 VAL A CG1 1 ATOM 1934 C CG2 . VAL A 1 246 ? -32.213 20.531 24.773 1.00 34.35 ? 246 VAL A CG2 1 ATOM 1935 N N . PRO A 1 247 ? -33.629 16.434 26.670 1.00 32.98 ? 247 PRO A N 1 ATOM 1936 C CA . PRO A 1 247 ? -33.462 15.063 27.136 1.00 32.60 ? 247 PRO A CA 1 ATOM 1937 C C . PRO A 1 247 ? -32.599 14.245 26.199 1.00 32.26 ? 247 PRO A C 1 ATOM 1938 O O . PRO A 1 247 ? -32.308 14.676 25.070 1.00 32.04 ? 247 PRO A O 1 ATOM 1939 C CB . PRO A 1 247 ? -34.903 14.500 27.107 1.00 32.56 ? 247 PRO A CB 1 ATOM 1940 C CG . PRO A 1 247 ? -35.789 15.647 26.828 1.00 31.80 ? 247 PRO A CG 1 ATOM 1941 C CD . PRO A 1 247 ? -34.972 16.636 26.097 1.00 32.88 ? 247 PRO A CD 1 ATOM 1942 N N . CYS A 1 248 ? -32.204 13.069 26.675 1.00 32.25 ? 248 CYS A N 1 ATOM 1943 C CA . CYS A 1 248 ? -31.606 12.026 25.822 1.00 32.41 ? 248 CYS A CA 1 ATOM 1944 C C . CYS A 1 248 ? -32.599 11.578 24.727 1.00 32.63 ? 248 CYS A C 1 ATOM 1945 O O . CYS A 1 248 ? -33.824 11.709 24.872 1.00 32.57 ? 248 CYS A O 1 ATOM 1946 C CB . CYS A 1 248 ? -31.163 10.822 26.672 1.00 32.09 ? 248 CYS A CB 1 ATOM 1947 S SG . CYS A 1 248 ? -30.129 11.224 28.136 1.00 31.50 ? 248 CYS A SG 1 ATOM 1948 N N . PHE A 1 249 ? -32.054 11.069 23.633 1.00 32.76 ? 249 PHE A N 1 ATOM 1949 C CA . PHE A 1 249 ? -32.839 10.497 22.560 1.00 33.06 ? 249 PHE A CA 1 ATOM 1950 C C . PHE A 1 249 ? -33.352 9.106 22.868 1.00 33.38 ? 249 PHE A C 1 ATOM 1951 O O . PHE A 1 249 ? -32.933 8.451 23.826 1.00 33.44 ? 249 PHE A O 1 ATOM 1952 C CB . PHE A 1 249 ? -32.018 10.451 21.271 1.00 33.25 ? 249 PHE A CB 1 ATOM 1953 C CG . PHE A 1 249 ? -31.545 11.803 20.813 1.00 34.87 ? 249 PHE A CG 1 ATOM 1954 C CD1 . PHE A 1 249 ? -30.200 12.113 20.818 1.00 35.21 ? 249 PHE A CD1 1 ATOM 1955 C CD2 . PHE A 1 249 ? -32.461 12.782 20.424 1.00 36.74 ? 249 PHE A CD2 1 ATOM 1956 C CE1 . PHE A 1 249 ? -29.755 13.374 20.420 1.00 36.69 ? 249 PHE A CE1 1 ATOM 1957 C CE2 . PHE A 1 249 ? -32.031 14.039 20.023 1.00 38.37 ? 249 PHE A CE2 1 ATOM 1958 C CZ . PHE A 1 249 ? -30.669 14.333 20.022 1.00 38.64 ? 249 PHE A CZ 1 ATOM 1959 N N . LEU A 1 250 ? -34.291 8.666 22.043 1.00 33.92 ? 250 LEU A N 1 ATOM 1960 C CA . LEU A 1 250 ? -34.788 7.323 22.138 1.00 34.25 ? 250 LEU A CA 1 ATOM 1961 C C . LEU A 1 250 ? -34.315 6.573 20.914 1.00 34.04 ? 250 LEU A C 1 ATOM 1962 O O . LEU A 1 250 ? -34.680 6.916 19.775 1.00 34.36 ? 250 LEU A O 1 ATOM 1963 C CB . LEU A 1 250 ? -36.308 7.301 22.251 1.00 34.66 ? 250 LEU A CB 1 ATOM 1964 C CG . LEU A 1 250 ? -36.832 5.881 22.482 1.00 35.12 ? 250 LEU A CG 1 ATOM 1965 C CD1 . LEU A 1 250 ? -36.411 5.342 23.834 1.00 32.95 ? 250 LEU A CD1 1 ATOM 1966 C CD2 . LEU A 1 250 ? -38.366 5.826 22.285 1.00 35.65 ? 250 LEU A CD2 1 ATOM 1967 N N . ALA A 1 251 ? -33.462 5.586 21.159 1.00 33.21 ? 251 ALA A N 1 ATOM 1968 C CA . ALA A 1 251 ? -32.909 4.764 20.104 1.00 32.90 ? 251 ALA A CA 1 ATOM 1969 C C . ALA A 1 251 ? -33.110 3.293 20.450 1.00 32.68 ? 251 ALA A C 1 ATOM 1970 O O . ALA A 1 251 ? -33.485 2.949 21.573 1.00 31.98 ? 251 ALA A O 1 ATOM 1971 C CB . ALA A 1 251 ? -31.447 5.069 19.901 1.00 32.57 ? 251 ALA A CB 1 ATOM 1972 N N . GLY A 1 252 ? -32.873 2.443 19.457 1.00 32.88 ? 252 GLY A N 1 ATOM 1973 C CA . GLY A 1 252 ? -32.958 1.009 19.608 1.00 32.76 ? 252 GLY A CA 1 ATOM 1974 C C . GLY A 1 252 ? -31.909 0.525 20.568 1.00 32.76 ? 252 GLY A C 1 ATOM 1975 O O . GLY A 1 252 ? -31.896 -0.634 20.941 1.00 33.29 ? 252 GLY A O 1 ATOM 1976 N N . ASP A 1 253 ? -31.023 1.423 20.971 1.00 32.81 ? 253 ASP A N 1 ATOM 1977 C CA . ASP A 1 253 ? -30.006 1.103 21.965 1.00 32.85 ? 253 ASP A CA 1 ATOM 1978 C C . ASP A 1 253 ? -29.936 2.235 22.960 1.00 33.27 ? 253 ASP A C 1 ATOM 1979 O O . ASP A 1 253 ? -29.787 3.391 22.587 1.00 33.97 ? 253 ASP A O 1 ATOM 1980 C CB . ASP A 1 253 ? -28.642 0.892 21.300 1.00 32.36 ? 253 ASP A CB 1 ATOM 1981 C CG . ASP A 1 253 ? -27.546 0.580 22.297 1.00 30.83 ? 253 ASP A CG 1 ATOM 1982 O OD1 . ASP A 1 253 ? -27.196 -0.601 22.401 1.00 29.00 ? 253 ASP A OD1 1 ATOM 1983 O OD2 . ASP A 1 253 ? -27.047 1.498 22.979 1.00 26.78 ? 253 ASP A OD2 1 ATOM 1984 N N . PHE A 1 254 ? -30.004 1.901 24.232 1.00 34.15 ? 254 PHE A N 1 ATOM 1985 C CA . PHE A 1 254 ? -30.070 2.928 25.267 1.00 35.85 ? 254 PHE A CA 1 ATOM 1986 C C . PHE A 1 254 ? -28.790 3.768 25.474 1.00 34.49 ? 254 PHE A C 1 ATOM 1987 O O . PHE A 1 254 ? -28.819 4.798 26.121 1.00 35.60 ? 254 PHE A O 1 ATOM 1988 C CB . PHE A 1 254 ? -30.567 2.306 26.587 1.00 36.89 ? 254 PHE A CB 1 ATOM 1989 C CG . PHE A 1 254 ? -32.059 1.990 26.591 1.00 41.90 ? 254 PHE A CG 1 ATOM 1990 C CD1 . PHE A 1 254 ? -32.961 2.769 25.853 1.00 44.68 ? 254 PHE A CD1 1 ATOM 1991 C CD2 . PHE A 1 254 ? -32.565 0.946 27.374 1.00 46.02 ? 254 PHE A CD2 1 ATOM 1992 C CE1 . PHE A 1 254 ? -34.335 2.511 25.867 1.00 45.75 ? 254 PHE A CE1 1 ATOM 1993 C CE2 . PHE A 1 254 ? -33.939 0.682 27.407 1.00 47.61 ? 254 PHE A CE2 1 ATOM 1994 C CZ . PHE A 1 254 ? -34.829 1.477 26.642 1.00 47.60 ? 254 PHE A CZ 1 ATOM 1995 N N . ARG A 1 255 ? -27.677 3.340 24.911 1.00 33.35 ? 255 ARG A N 1 ATOM 1996 C CA . ARG A 1 255 ? -26.410 4.056 25.092 1.00 31.23 ? 255 ARG A CA 1 ATOM 1997 C C . ARG A 1 255 ? -26.248 5.221 24.147 1.00 30.61 ? 255 ARG A C 1 ATOM 1998 O O . ARG A 1 255 ? -25.215 5.885 24.205 1.00 30.86 ? 255 ARG A O 1 ATOM 1999 C CB . ARG A 1 255 ? -25.218 3.103 24.945 1.00 29.87 ? 255 ARG A CB 1 ATOM 2000 C CG . ARG A 1 255 ? -25.242 1.991 25.944 1.00 27.31 ? 255 ARG A CG 1 ATOM 2001 C CD . ARG A 1 255 ? -24.342 0.830 25.588 1.00 22.73 ? 255 ARG A CD 1 ATOM 2002 N NE . ARG A 1 255 ? -24.864 -0.042 24.532 1.00 20.16 ? 255 ARG A NE 1 ATOM 2003 C CZ . ARG A 1 255 ? -24.269 -1.159 24.129 1.00 18.14 ? 255 ARG A CZ 1 ATOM 2004 N NH1 . ARG A 1 255 ? -23.147 -1.567 24.711 1.00 18.77 ? 255 ARG A NH1 1 ATOM 2005 N NH2 . ARG A 1 255 ? -24.802 -1.889 23.157 1.00 20.82 ? 255 ARG A NH2 1 ATOM 2006 N N . ALA A 1 256 ? -27.264 5.494 23.317 1.00 29.43 ? 256 ALA A N 1 ATOM 2007 C CA . ALA A 1 256 ? -27.110 6.379 22.136 1.00 28.36 ? 256 ALA A CA 1 ATOM 2008 C C . ALA A 1 256 ? -26.692 7.813 22.394 1.00 27.68 ? 256 ALA A C 1 ATOM 2009 O O . ALA A 1 256 ? -25.999 8.408 21.594 1.00 27.22 ? 256 ALA A O 1 ATOM 2010 C CB . ALA A 1 256 ? -28.366 6.335 21.247 1.00 28.65 ? 256 ALA A CB 1 ATOM 2011 N N . SER A 1 257 ? -27.125 8.387 23.504 1.00 28.46 ? 257 SER A N 1 ATOM 2012 C CA . SER A 1 257 ? -26.735 9.768 23.852 1.00 28.35 ? 257 SER A CA 1 ATOM 2013 C C . SER A 1 257 ? -25.545 9.869 24.844 1.00 28.35 ? 257 SER A C 1 ATOM 2014 O O . SER A 1 257 ? -25.286 10.924 25.466 1.00 28.18 ? 257 SER A O 1 ATOM 2015 C CB . SER A 1 257 ? -27.951 10.600 24.296 1.00 28.56 ? 257 SER A CB 1 ATOM 2016 O OG . SER A 1 257 ? -28.944 9.828 24.951 1.00 28.66 ? 257 SER A OG 1 ATOM 2017 N N . GLU A 1 258 ? -24.806 8.771 24.960 1.00 27.60 ? 258 GLU A N 1 ATOM 2018 C CA . GLU A 1 258 ? -23.635 8.722 25.827 1.00 27.05 ? 258 GLU A CA 1 ATOM 2019 C C . GLU A 1 258 ? -22.659 9.862 25.538 1.00 26.44 ? 258 GLU A C 1 ATOM 2020 O O . GLU A 1 258 ? -22.120 10.472 26.461 1.00 26.61 ? 258 GLU A O 1 ATOM 2021 C CB . GLU A 1 258 ? -22.923 7.374 25.687 1.00 27.08 ? 258 GLU A CB 1 ATOM 2022 C CG . GLU A 1 258 ? -22.062 7.001 26.883 1.00 25.41 ? 258 GLU A CG 1 ATOM 2023 C CD . GLU A 1 258 ? -20.581 7.174 26.611 1.00 24.93 ? 258 GLU A CD 1 ATOM 2024 O OE1 . GLU A 1 258 ? -20.192 7.202 25.425 1.00 25.64 ? 258 GLU A OE1 1 ATOM 2025 O OE2 . GLU A 1 258 ? -19.805 7.283 27.584 1.00 24.62 ? 258 GLU A OE2 1 ATOM 2026 N N . GLN A 1 259 ? -22.431 10.144 24.258 1.00 25.48 ? 259 GLN A N 1 ATOM 2027 C CA . GLN A 1 259 ? -21.506 11.171 23.877 1.00 25.12 ? 259 GLN A CA 1 ATOM 2028 C C . GLN A 1 259 ? -22.063 11.597 22.568 1.00 25.75 ? 259 GLN A C 1 ATOM 2029 O O . GLN A 1 259 ? -22.779 10.827 21.931 1.00 25.71 ? 259 GLN A O 1 ATOM 2030 C CB . GLN A 1 259 ? -20.052 10.687 23.756 1.00 24.38 ? 259 GLN A CB 1 ATOM 2031 C CG . GLN A 1 259 ? -19.806 9.551 22.795 1.00 23.18 ? 259 GLN A CG 1 ATOM 2032 C CD . GLN A 1 259 ? -19.390 10.050 21.432 1.00 20.35 ? 259 GLN A CD 1 ATOM 2033 O OE1 . GLN A 1 259 ? -19.453 11.245 21.153 1.00 20.53 ? 259 GLN A OE1 1 ATOM 2034 N NE2 . GLN A 1 259 ? -18.996 9.143 20.575 1.00 18.74 ? 259 GLN A NE2 1 ATOM 2035 N N . ILE A 1 260 ? -21.750 12.827 22.184 1.00 26.15 ? 260 ILE A N 1 ATOM 2036 C CA . ILE A 1 260 ? -22.536 13.526 21.182 1.00 26.73 ? 260 ILE A CA 1 ATOM 2037 C C . ILE A 1 260 ? -22.393 12.876 19.815 1.00 26.84 ? 260 ILE A C 1 ATOM 2038 O O . ILE A 1 260 ? -23.374 12.827 19.060 1.00 27.55 ? 260 ILE A O 1 ATOM 2039 C CB . ILE A 1 260 ? -22.157 15.022 21.127 1.00 26.99 ? 260 ILE A CB 1 ATOM 2040 C CG1 . ILE A 1 260 ? -23.176 15.826 20.339 1.00 27.78 ? 260 ILE A CG1 1 ATOM 2041 C CG2 . ILE A 1 260 ? -20.738 15.232 20.538 1.00 26.61 ? 260 ILE A CG2 1 ATOM 2042 C CD1 . ILE A 1 260 ? -23.026 17.336 20.592 1.00 31.51 ? 260 ILE A CD1 1 ATOM 2043 N N . LEU A 1 261 ? -21.181 12.404 19.496 1.00 25.78 ? 261 LEU A N 1 ATOM 2044 C CA . LEU A 1 261 ? -20.918 11.778 18.210 1.00 25.30 ? 261 LEU A CA 1 ATOM 2045 C C . LEU A 1 261 ? -21.637 10.412 18.055 1.00 25.52 ? 261 LEU A C 1 ATOM 2046 O O . LEU A 1 261 ? -22.152 10.085 16.974 1.00 24.94 ? 261 LEU A O 1 ATOM 2047 C CB . LEU A 1 261 ? -19.417 11.695 17.918 1.00 24.43 ? 261 LEU A CB 1 ATOM 2048 C CG . LEU A 1 261 ? -18.672 13.043 17.797 1.00 25.03 ? 261 LEU A CG 1 ATOM 2049 C CD1 . LEU A 1 261 ? -17.271 12.855 17.273 1.00 24.46 ? 261 LEU A CD1 1 ATOM 2050 C CD2 . LEU A 1 261 ? -19.376 13.985 16.849 1.00 24.08 ? 261 LEU A CD2 1 ATOM 2051 N N . LEU A 1 262 ? -21.708 9.628 19.128 1.00 25.23 ? 262 LEU A N 1 ATOM 2052 C CA . LEU A 1 262 ? -22.503 8.416 19.068 1.00 25.01 ? 262 LEU A CA 1 ATOM 2053 C C . LEU A 1 262 ? -23.901 8.820 18.610 1.00 25.50 ? 262 LEU A C 1 ATOM 2054 O O . LEU A 1 262 ? -24.411 8.264 17.628 1.00 25.98 ? 262 LEU A O 1 ATOM 2055 C CB . LEU A 1 262 ? -22.554 7.712 20.409 1.00 24.51 ? 262 LEU A CB 1 ATOM 2056 C CG . LEU A 1 262 ? -23.364 6.426 20.543 1.00 24.31 ? 262 LEU A CG 1 ATOM 2057 C CD1 . LEU A 1 262 ? -22.981 5.315 19.544 1.00 22.11 ? 262 LEU A CD1 1 ATOM 2058 C CD2 . LEU A 1 262 ? -23.188 5.955 21.945 1.00 21.76 ? 262 LEU A CD2 1 ATOM 2059 N N . ALA A 1 263 ? -24.469 9.831 19.270 1.00 25.53 ? 263 ALA A N 1 ATOM 2060 C CA . ALA A 1 263 ? -25.860 10.280 19.040 1.00 25.91 ? 263 ALA A CA 1 ATOM 2061 C C . ALA A 1 263 ? -26.052 10.806 17.625 1.00 26.07 ? 263 ALA A C 1 ATOM 2062 O O . ALA A 1 263 ? -27.139 10.721 17.079 1.00 27.11 ? 263 ALA A O 1 ATOM 2063 C CB . ALA A 1 263 ? -26.269 11.348 20.071 1.00 25.03 ? 263 ALA A CB 1 ATOM 2064 N N . THR A 1 264 ? -24.992 11.350 17.052 1.00 25.86 ? 264 THR A N 1 ATOM 2065 C CA . THR A 1 264 ? -24.962 11.816 15.677 1.00 26.43 ? 264 THR A CA 1 ATOM 2066 C C . THR A 1 264 ? -25.057 10.680 14.633 1.00 27.23 ? 264 THR A C 1 ATOM 2067 O O . THR A 1 264 ? -25.704 10.824 13.559 1.00 26.89 ? 264 THR A O 1 ATOM 2068 C CB . THR A 1 264 ? -23.636 12.545 15.443 1.00 26.48 ? 264 THR A CB 1 ATOM 2069 O OG1 . THR A 1 264 ? -23.614 13.781 16.188 1.00 27.20 ? 264 THR A OG1 1 ATOM 2070 C CG2 . THR A 1 264 ? -23.398 12.795 13.983 1.00 25.66 ? 264 THR A CG2 1 ATOM 2071 N N . ALA A 1 265 ? -24.373 9.574 14.929 1.00 27.10 ? 265 ALA A N 1 ATOM 2072 C CA . ALA A 1 265 ? -24.248 8.463 14.018 1.00 26.66 ? 265 ALA A CA 1 ATOM 2073 C C . ALA A 1 265 ? -25.570 7.764 13.996 1.00 27.21 ? 265 ALA A C 1 ATOM 2074 O O . ALA A 1 265 ? -26.066 7.403 12.922 1.00 28.14 ? 265 ALA A O 1 ATOM 2075 C CB . ALA A 1 265 ? -23.173 7.522 14.497 1.00 27.18 ? 265 ALA A CB 1 ATOM 2076 N N . HIS A 1 266 ? -26.138 7.591 15.194 1.00 26.71 ? 266 HIS A N 1 ATOM 2077 C CA . HIS A 1 266 ? -27.445 7.020 15.381 1.00 26.91 ? 266 HIS A CA 1 ATOM 2078 C C . HIS A 1 266 ? -28.449 7.830 14.592 1.00 27.56 ? 266 HIS A C 1 ATOM 2079 O O . HIS A 1 266 ? -29.376 7.285 14.000 1.00 28.21 ? 266 HIS A O 1 ATOM 2080 C CB . HIS A 1 266 ? -27.840 7.074 16.862 1.00 26.74 ? 266 HIS A CB 1 ATOM 2081 C CG . HIS A 1 266 ? -27.464 5.849 17.647 1.00 26.25 ? 266 HIS A CG 1 ATOM 2082 N ND1 . HIS A 1 266 ? -28.255 4.719 17.690 1.00 25.79 ? 266 HIS A ND1 1 ATOM 2083 C CD2 . HIS A 1 266 ? -26.415 5.603 18.468 1.00 26.46 ? 266 HIS A CD2 1 ATOM 2084 C CE1 . HIS A 1 266 ? -27.698 3.820 18.484 1.00 28.43 ? 266 HIS A CE1 1 ATOM 2085 N NE2 . HIS A 1 266 ? -26.575 4.326 18.965 1.00 28.84 ? 266 HIS A NE2 1 ATOM 2086 N N . THR A 1 267 ? -28.264 9.148 14.624 1.00 27.92 ? 267 THR A N 1 ATOM 2087 C CA . THR A 1 267 ? -29.145 10.094 13.947 1.00 27.65 ? 267 THR A CA 1 ATOM 2088 C C . THR A 1 267 ? -29.118 9.925 12.433 1.00 28.06 ? 267 THR A C 1 ATOM 2089 O O . THR A 1 267 ? -30.175 9.846 11.829 1.00 29.04 ? 267 THR A O 1 ATOM 2090 C CB . THR A 1 267 ? -28.882 11.542 14.424 1.00 26.95 ? 267 THR A CB 1 ATOM 2091 O OG1 . THR A 1 267 ? -29.448 11.667 15.731 1.00 27.31 ? 267 THR A OG1 1 ATOM 2092 C CG2 . THR A 1 267 ? -29.521 12.570 13.514 1.00 24.81 ? 267 THR A CG2 1 ATOM 2093 N N . LEU A 1 268 ? -27.927 9.839 11.850 1.00 28.20 ? 268 LEU A N 1 ATOM 2094 C CA . LEU A 1 268 ? -27.743 9.467 10.443 1.00 29.21 ? 268 LEU A CA 1 ATOM 2095 C C . LEU A 1 268 ? -28.407 8.141 10.005 1.00 30.97 ? 268 LEU A C 1 ATOM 2096 O O . LEU A 1 268 ? -28.981 8.064 8.913 1.00 32.08 ? 268 LEU A O 1 ATOM 2097 C CB . LEU A 1 268 ? -26.258 9.387 10.126 1.00 28.18 ? 268 LEU A CB 1 ATOM 2098 C CG . LEU A 1 268 ? -25.474 10.686 10.147 1.00 25.98 ? 268 LEU A CG 1 ATOM 2099 C CD1 . LEU A 1 268 ? -24.025 10.480 9.692 1.00 23.23 ? 268 LEU A CD1 1 ATOM 2100 C CD2 . LEU A 1 268 ? -26.191 11.608 9.246 1.00 24.28 ? 268 LEU A CD2 1 ATOM 2101 N N . LEU A 1 269 ? -28.307 7.112 10.851 1.00 32.32 ? 269 LEU A N 1 ATOM 2102 C CA . LEU A 1 269 ? -28.884 5.779 10.595 1.00 33.52 ? 269 LEU A CA 1 ATOM 2103 C C . LEU A 1 269 ? -30.406 5.767 10.511 1.00 34.60 ? 269 LEU A C 1 ATOM 2104 O O . LEU A 1 269 ? -30.969 5.055 9.671 1.00 34.91 ? 269 LEU A O 1 ATOM 2105 C CB . LEU A 1 269 ? -28.416 4.758 11.658 1.00 32.55 ? 269 LEU A CB 1 ATOM 2106 C CG . LEU A 1 269 ? -26.934 4.368 11.572 1.00 31.65 ? 269 LEU A CG 1 ATOM 2107 C CD1 . LEU A 1 269 ? -26.435 3.715 12.845 1.00 28.15 ? 269 LEU A CD1 1 ATOM 2108 C CD2 . LEU A 1 269 ? -26.677 3.471 10.367 1.00 29.29 ? 269 LEU A CD2 1 ATOM 2109 N N . LEU A 1 270 ? -31.069 6.523 11.385 1.00 35.59 ? 270 LEU A N 1 ATOM 2110 C CA . LEU A 1 270 ? -32.530 6.649 11.290 1.00 37.35 ? 270 LEU A CA 1 ATOM 2111 C C . LEU A 1 270 ? -32.896 7.396 10.006 1.00 37.49 ? 270 LEU A C 1 ATOM 2112 O O . LEU A 1 270 ? -33.820 7.024 9.311 1.00 38.12 ? 270 LEU A O 1 ATOM 2113 C CB . LEU A 1 270 ? -33.128 7.380 12.508 1.00 37.47 ? 270 LEU A CB 1 ATOM 2114 C CG . LEU A 1 270 ? -34.635 7.171 12.755 1.00 39.38 ? 270 LEU A CG 1 ATOM 2115 C CD1 . LEU A 1 270 ? -34.857 5.963 13.699 1.00 41.20 ? 270 LEU A CD1 1 ATOM 2116 C CD2 . LEU A 1 270 ? -35.308 8.407 13.323 1.00 40.04 ? 270 LEU A CD2 1 ATOM 2117 N N . ARG A 1 271 ? -32.158 8.448 9.686 1.00 38.04 ? 271 ARG A N 1 ATOM 2118 C CA . ARG A 1 271 ? -32.455 9.200 8.466 1.00 39.04 ? 271 ARG A CA 1 ATOM 2119 C C . ARG A 1 271 ? -32.301 8.322 7.250 1.00 40.12 ? 271 ARG A C 1 ATOM 2120 O O . ARG A 1 271 ? -32.992 8.533 6.260 1.00 40.67 ? 271 ARG A O 1 ATOM 2121 C CB . ARG A 1 271 ? -31.579 10.443 8.321 1.00 38.04 ? 271 ARG A CB 1 ATOM 2122 C CG . ARG A 1 271 ? -31.863 11.452 9.379 1.00 35.75 ? 271 ARG A CG 1 ATOM 2123 C CD . ARG A 1 271 ? -30.968 12.637 9.256 1.00 33.88 ? 271 ARG A CD 1 ATOM 2124 N NE . ARG A 1 271 ? -31.317 13.599 10.297 1.00 32.03 ? 271 ARG A NE 1 ATOM 2125 C CZ . ARG A 1 271 ? -30.663 14.721 10.544 1.00 28.86 ? 271 ARG A CZ 1 ATOM 2126 N NH1 . ARG A 1 271 ? -29.597 15.080 9.830 1.00 24.56 ? 271 ARG A NH1 1 ATOM 2127 N NH2 . ARG A 1 271 ? -31.097 15.485 11.525 1.00 31.39 ? 271 ARG A NH2 1 ATOM 2128 N N . GLU A 1 272 ? -31.406 7.335 7.322 1.00 40.85 ? 272 GLU A N 1 ATOM 2129 C CA . GLU A 1 272 ? -31.239 6.426 6.198 1.00 41.58 ? 272 GLU A CA 1 ATOM 2130 C C . GLU A 1 272 ? -32.419 5.511 6.089 1.00 41.57 ? 272 GLU A C 1 ATOM 2131 O O . GLU A 1 272 ? -32.905 5.273 4.996 1.00 41.22 ? 272 GLU A O 1 ATOM 2132 C CB . GLU A 1 272 ? -29.972 5.595 6.303 1.00 42.37 ? 272 GLU A CB 1 ATOM 2133 C CG . GLU A 1 272 ? -29.805 4.652 5.137 1.00 43.44 ? 272 GLU A CG 1 ATOM 2134 C CD . GLU A 1 272 ? -29.857 5.354 3.771 1.00 45.87 ? 272 GLU A CD 1 ATOM 2135 O OE1 . GLU A 1 272 ? -29.675 6.591 3.689 1.00 46.47 ? 272 GLU A OE1 1 ATOM 2136 O OE2 . GLU A 1 272 ? -30.059 4.649 2.765 1.00 47.06 ? 272 GLU A OE2 1 ATOM 2137 N N . HIS A 1 273 ? -32.878 5.000 7.224 1.00 41.69 ? 273 HIS A N 1 ATOM 2138 C CA . HIS A 1 273 ? -34.046 4.167 7.217 1.00 42.67 ? 273 HIS A CA 1 ATOM 2139 C C . HIS A 1 273 ? -35.136 4.862 6.412 1.00 43.23 ? 273 HIS A C 1 ATOM 2140 O O . HIS A 1 273 ? -35.450 4.470 5.274 1.00 43.09 ? 273 HIS A O 1 ATOM 2141 C CB . HIS A 1 273 ? -34.526 3.899 8.629 1.00 42.73 ? 273 HIS A CB 1 ATOM 2142 C CG . HIS A 1 273 ? -35.746 3.044 8.679 1.00 45.60 ? 273 HIS A CG 1 ATOM 2143 N ND1 . HIS A 1 273 ? -35.689 1.673 8.821 1.00 47.96 ? 273 HIS A ND1 1 ATOM 2144 C CD2 . HIS A 1 273 ? -37.058 3.354 8.566 1.00 47.23 ? 273 HIS A CD2 1 ATOM 2145 C CE1 . HIS A 1 273 ? -36.915 1.177 8.824 1.00 48.03 ? 273 HIS A CE1 1 ATOM 2146 N NE2 . HIS A 1 273 ? -37.765 2.177 8.682 1.00 49.06 ? 273 HIS A NE2 1 ATOM 2147 N N . ASN A 1 274 ? -35.673 5.931 6.998 1.00 43.71 ? 274 ASN A N 1 ATOM 2148 C CA . ASN A 1 274 ? -36.708 6.726 6.377 1.00 43.68 ? 274 ASN A CA 1 ATOM 2149 C C . ASN A 1 274 ? -36.445 7.126 4.934 1.00 44.27 ? 274 ASN A C 1 ATOM 2150 O O . ASN A 1 274 ? -37.287 6.897 4.082 1.00 44.56 ? 274 ASN A O 1 ATOM 2151 C CB . ASN A 1 274 ? -37.077 7.869 7.298 1.00 43.33 ? 274 ASN A CB 1 ATOM 2152 C CG . ASN A 1 274 ? -37.664 7.354 8.547 1.00 42.54 ? 274 ASN A CG 1 ATOM 2153 O OD1 . ASN A 1 274 ? -37.586 6.154 8.789 1.00 43.07 ? 274 ASN A OD1 1 ATOM 2154 N ND2 . ASN A 1 274 ? -38.294 8.208 9.336 1.00 42.16 ? 274 ASN A ND2 1 ATOM 2155 N N . ARG A 1 275 ? -35.277 7.665 4.637 1.00 45.13 ? 275 ARG A N 1 ATOM 2156 C CA . ARG A 1 275 ? -34.910 7.839 3.244 1.00 46.69 ? 275 ARG A CA 1 ATOM 2157 C C . ARG A 1 275 ? -35.209 6.545 2.474 1.00 48.25 ? 275 ARG A C 1 ATOM 2158 O O . ARG A 1 275 ? -36.057 6.546 1.576 1.00 48.64 ? 275 ARG A O 1 ATOM 2159 C CB . ARG A 1 275 ? -33.442 8.185 3.116 1.00 46.28 ? 275 ARG A CB 1 ATOM 2160 C CG . ARG A 1 275 ? -33.052 8.704 1.780 1.00 46.72 ? 275 ARG A CG 1 ATOM 2161 C CD . ARG A 1 275 ? -31.587 8.458 1.569 1.00 48.85 ? 275 ARG A CD 1 ATOM 2162 N NE . ARG A 1 275 ? -31.304 7.078 1.168 1.00 49.10 ? 275 ARG A NE 1 ATOM 2163 C CZ . ARG A 1 275 ? -30.192 6.711 0.533 1.00 49.54 ? 275 ARG A CZ 1 ATOM 2164 N NH1 . ARG A 1 275 ? -29.266 7.618 0.254 1.00 48.29 ? 275 ARG A NH1 1 ATOM 2165 N NH2 . ARG A 1 275 ? -29.993 5.443 0.191 1.00 48.04 ? 275 ARG A NH2 1 ATOM 2166 N N . LEU A 1 276 ? -34.536 5.450 2.847 1.00 49.72 ? 276 LEU A N 1 ATOM 2167 C CA . LEU A 1 276 ? -34.694 4.133 2.183 1.00 51.03 ? 276 LEU A CA 1 ATOM 2168 C C . LEU A 1 276 ? -36.144 3.729 2.039 1.00 51.67 ? 276 LEU A C 1 ATOM 2169 O O . LEU A 1 276 ? -36.565 3.358 0.952 1.00 51.76 ? 276 LEU A O 1 ATOM 2170 C CB . LEU A 1 276 ? -33.958 3.007 2.934 1.00 51.00 ? 276 LEU A CB 1 ATOM 2171 C CG . LEU A 1 276 ? -32.486 2.731 2.657 1.00 51.10 ? 276 LEU A CG 1 ATOM 2172 C CD1 . LEU A 1 276 ? -31.889 1.919 3.767 1.00 51.85 ? 276 LEU A CD1 1 ATOM 2173 C CD2 . LEU A 1 276 ? -32.329 1.992 1.359 1.00 53.14 ? 276 LEU A CD2 1 ATOM 2174 N N . ALA A 1 277 ? -36.888 3.802 3.143 1.00 52.73 ? 277 ALA A N 1 ATOM 2175 C CA . ALA A 1 277 ? -38.306 3.470 3.169 1.00 53.66 ? 277 ALA A CA 1 ATOM 2176 C C . ALA A 1 277 ? -39.063 4.263 2.104 1.00 55.10 ? 277 ALA A C 1 ATOM 2177 O O . ALA A 1 277 ? -39.755 3.678 1.259 1.00 55.51 ? 277 ALA A O 1 ATOM 2178 C CB . ALA A 1 277 ? -38.885 3.742 4.542 1.00 52.86 ? 277 ALA A CB 1 ATOM 2179 N N . ARG A 1 278 ? -38.910 5.589 2.127 1.00 56.22 ? 278 ARG A N 1 ATOM 2180 C CA . ARG A 1 278 ? -39.682 6.456 1.248 1.00 57.20 ? 278 ARG A CA 1 ATOM 2181 C C . ARG A 1 278 ? -39.383 6.178 -0.227 1.00 58.39 ? 278 ARG A C 1 ATOM 2182 O O . ARG A 1 278 ? -40.310 6.053 -1.045 1.00 58.96 ? 278 ARG A O 1 ATOM 2183 C CB . ARG A 1 278 ? -39.473 7.932 1.603 1.00 57.00 ? 278 ARG A CB 1 ATOM 2184 C CG . ARG A 1 278 ? -40.382 8.415 2.736 1.00 56.26 ? 278 ARG A CG 1 ATOM 2185 C CD . ARG A 1 278 ? -40.300 9.936 2.913 1.00 55.34 ? 278 ARG A CD 1 ATOM 2186 N NE . ARG A 1 278 ? -39.193 10.304 3.788 1.00 54.45 ? 278 ARG A NE 1 ATOM 2187 C CZ . ARG A 1 278 ? -39.314 10.711 5.056 1.00 53.07 ? 278 ARG A CZ 1 ATOM 2188 N NH1 . ARG A 1 278 ? -40.510 10.850 5.635 1.00 49.33 ? 278 ARG A NH1 1 ATOM 2189 N NH2 . ARG A 1 278 ? -38.214 10.992 5.743 1.00 52.32 ? 278 ARG A NH2 1 ATOM 2190 N N . GLU A 1 279 ? -38.096 6.060 -0.557 1.00 59.36 ? 279 GLU A N 1 ATOM 2191 C CA . GLU A 1 279 ? -37.679 5.684 -1.901 1.00 60.08 ? 279 GLU A CA 1 ATOM 2192 C C . GLU A 1 279 ? -38.370 4.389 -2.345 1.00 60.53 ? 279 GLU A C 1 ATOM 2193 O O . GLU A 1 279 ? -38.579 4.182 -3.546 1.00 60.66 ? 279 GLU A O 1 ATOM 2194 C CB . GLU A 1 279 ? -36.153 5.533 -1.991 1.00 60.48 ? 279 GLU A CB 1 ATOM 2195 C CG . GLU A 1 279 ? -35.375 6.826 -2.255 1.00 61.40 ? 279 GLU A CG 1 ATOM 2196 C CD . GLU A 1 279 ? -35.862 7.585 -3.486 1.00 64.17 ? 279 GLU A CD 1 ATOM 2197 O OE1 . GLU A 1 279 ? -35.734 7.058 -4.617 1.00 65.09 ? 279 GLU A OE1 1 ATOM 2198 O OE2 . GLU A 1 279 ? -36.372 8.717 -3.321 1.00 66.08 ? 279 GLU A OE2 1 ATOM 2199 N N . LEU A 1 280 ? -38.738 3.541 -1.375 1.00 60.74 ? 280 LEU A N 1 ATOM 2200 C CA . LEU A 1 280 ? -39.377 2.253 -1.652 1.00 60.68 ? 280 LEU A CA 1 ATOM 2201 C C . LEU A 1 280 ? -40.838 2.428 -2.027 1.00 61.12 ? 280 LEU A C 1 ATOM 2202 O O . LEU A 1 280 ? -41.290 1.834 -2.999 1.00 61.16 ? 280 LEU A O 1 ATOM 2203 C CB . LEU A 1 280 ? -39.275 1.282 -0.458 1.00 60.51 ? 280 LEU A CB 1 ATOM 2204 C CG . LEU A 1 280 ? -37.981 0.618 0.003 1.00 58.90 ? 280 LEU A CG 1 ATOM 2205 C CD1 . LEU A 1 280 ? -38.223 -0.102 1.322 1.00 55.62 ? 280 LEU A CD1 1 ATOM 2206 C CD2 . LEU A 1 280 ? -37.447 -0.323 -1.065 1.00 57.94 ? 280 LEU A CD2 1 ATOM 2207 N N . LYS A 1 281 ? -41.588 3.200 -1.241 1.00 61.46 ? 281 LYS A N 1 ATOM 2208 C CA . LYS A 1 281 ? -42.995 3.454 -1.576 1.00 61.81 ? 281 LYS A CA 1 ATOM 2209 C C . LYS A 1 281 ? -43.095 4.154 -2.939 1.00 61.58 ? 281 LYS A C 1 ATOM 2210 O O . LYS A 1 281 ? -43.919 3.792 -3.776 1.00 61.38 ? 281 LYS A O 1 ATOM 2211 C CB . LYS A 1 281 ? -43.696 4.264 -0.493 1.00 61.79 ? 281 LYS A CB 1 ATOM 2212 C CG . LYS A 1 281 ? -45.171 4.453 -0.728 1.00 61.61 ? 281 LYS A CG 1 ATOM 2213 C CD . LYS A 1 281 ? -45.962 3.275 -0.222 1.00 63.12 ? 281 LYS A CD 1 ATOM 2214 C CE . LYS A 1 281 ? -47.407 3.673 0.084 1.00 62.86 ? 281 LYS A CE 1 ATOM 2215 N NZ . LYS A 1 281 ? -47.991 2.834 1.175 1.00 62.71 ? 281 LYS A NZ 1 ATOM 2216 N N . LYS A 1 282 ? -42.218 5.125 -3.169 1.00 61.60 ? 282 LYS A N 1 ATOM 2217 C CA . LYS A 1 282 ? -42.105 5.755 -4.485 1.00 61.43 ? 282 LYS A CA 1 ATOM 2218 C C . LYS A 1 282 ? -41.647 4.730 -5.511 1.00 61.28 ? 282 LYS A C 1 ATOM 2219 O O . LYS A 1 282 ? -41.276 5.079 -6.632 1.00 61.43 ? 282 LYS A O 1 ATOM 2220 C CB . LYS A 1 282 ? -41.189 6.979 -4.438 1.00 61.34 ? 282 LYS A CB 1 ATOM 2221 C CG . LYS A 1 282 ? -41.861 8.157 -3.748 1.00 62.08 ? 282 LYS A CG 1 ATOM 2222 C CD . LYS A 1 282 ? -40.879 9.037 -2.996 1.00 63.68 ? 282 LYS A CD 1 ATOM 2223 C CE . LYS A 1 282 ? -41.536 9.656 -1.752 1.00 63.62 ? 282 LYS A CE 1 ATOM 2224 N NZ . LYS A 1 282 ? -40.604 10.559 -0.994 1.00 63.40 ? 282 LYS A NZ 1 ATOM 2225 N N . LEU A 1 283 ? -41.704 3.457 -5.112 1.00 61.07 ? 283 LEU A N 1 ATOM 2226 C CA . LEU A 1 283 ? -41.468 2.334 -6.016 1.00 60.77 ? 283 LEU A CA 1 ATOM 2227 C C . LEU A 1 283 ? -42.744 1.538 -5.759 1.00 60.77 ? 283 LEU A C 1 ATOM 2228 O O . LEU A 1 283 ? -43.432 1.180 -6.712 1.00 60.94 ? 283 LEU A O 1 ATOM 2229 C CB . LEU A 1 283 ? -40.014 1.856 -5.949 1.00 60.73 ? 283 LEU A CB 1 ATOM 2230 C CG . LEU A 1 283 ? -39.048 2.457 -6.977 1.00 60.76 ? 283 LEU A CG 1 ATOM 2231 C CD1 . LEU A 1 283 ? -37.607 2.300 -6.521 1.00 60.39 ? 283 LEU A CD1 1 ATOM 2232 C CD2 . LEU A 1 283 ? -39.243 1.809 -8.338 1.00 60.43 ? 283 LEU A CD2 1 ATOM 2233 N N . ASN A 1 284 ? -42.987 1.115 -4.539 1.00 60.36 ? 284 ASN A N 1 ATOM 2234 C CA . ASN A 1 284 ? -44.093 0.226 -4.287 1.00 60.43 ? 284 ASN A CA 1 ATOM 2235 C C . ASN A 1 284 ? -45.186 0.636 -3.393 1.00 60.36 ? 284 ASN A C 1 ATOM 2236 O O . ASN A 1 284 ? -45.168 0.479 -2.200 1.00 60.36 ? 284 ASN A O 1 ATOM 2237 C CB . ASN A 1 284 ? -43.553 -1.011 -3.666 1.00 60.70 ? 284 ASN A CB 1 ATOM 2238 C CG . ASN A 1 284 ? -42.390 -1.484 -4.372 1.00 62.19 ? 284 ASN A CG 1 ATOM 2239 O OD1 . ASN A 1 284 ? -41.824 -2.475 -4.016 1.00 63.44 ? 284 ASN A OD1 1 ATOM 2240 N ND2 . ASN A 1 284 ? -42.006 -0.777 -5.412 1.00 63.61 ? 284 ASN A ND2 1 ATOM 2241 N N . PRO A 1 285 ? -46.255 1.085 -3.997 1.00 60.32 ? 285 PRO A N 1 ATOM 2242 C CA . PRO A 1 285 ? -47.422 1.505 -3.268 1.00 60.10 ? 285 PRO A CA 1 ATOM 2243 C C . PRO A 1 285 ? -48.167 0.354 -2.655 1.00 60.42 ? 285 PRO A C 1 ATOM 2244 O O . PRO A 1 285 ? -48.927 0.566 -1.728 1.00 60.50 ? 285 PRO A O 1 ATOM 2245 C CB . PRO A 1 285 ? -48.238 2.189 -4.327 1.00 59.96 ? 285 PRO A CB 1 ATOM 2246 C CG . PRO A 1 285 ? -47.309 2.626 -5.271 1.00 60.15 ? 285 PRO A CG 1 ATOM 2247 C CD . PRO A 1 285 ? -46.272 1.607 -5.358 1.00 60.65 ? 285 PRO A CD 1 ATOM 2248 N N . HIS A 1 286 ? -48.002 -0.845 -3.180 1.00 60.36 ? 286 HIS A N 1 ATOM 2249 C CA . HIS A 1 286 ? -48.724 -1.965 -2.653 1.00 60.58 ? 286 HIS A CA 1 ATOM 2250 C C . HIS A 1 286 ? -48.400 -2.243 -1.217 1.00 61.14 ? 286 HIS A C 1 ATOM 2251 O O . HIS A 1 286 ? -49.280 -2.503 -0.413 1.00 60.89 ? 286 HIS A O 1 ATOM 2252 C CB . HIS A 1 286 ? -48.465 -3.235 -3.452 1.00 60.38 ? 286 HIS A CB 1 ATOM 2253 C CG . HIS A 1 286 ? -47.379 -3.107 -4.459 1.00 59.18 ? 286 HIS A CG 1 ATOM 2254 N ND1 . HIS A 1 286 ? -47.111 -1.932 -5.107 1.00 59.15 ? 286 HIS A ND1 1 ATOM 2255 C CD2 . HIS A 1 286 ? -46.524 -4.014 -4.968 1.00 58.86 ? 286 HIS A CD2 1 ATOM 2256 C CE1 . HIS A 1 286 ? -46.119 -2.108 -5.956 1.00 58.39 ? 286 HIS A CE1 1 ATOM 2257 N NE2 . HIS A 1 286 ? -45.738 -3.363 -5.884 1.00 58.79 ? 286 HIS A NE2 1 ATOM 2258 N N . TRP A 1 287 ? -47.119 -2.166 -0.889 1.00 61.75 ? 287 TRP A N 1 ATOM 2259 C CA . TRP A 1 287 ? -46.656 -2.603 0.430 1.00 61.96 ? 287 TRP A CA 1 ATOM 2260 C C . TRP A 1 287 ? -47.339 -1.836 1.553 1.00 61.47 ? 287 TRP A C 1 ATOM 2261 O O . TRP A 1 287 ? -47.699 -0.666 1.404 1.00 61.83 ? 287 TRP A O 1 ATOM 2262 C CB . TRP A 1 287 ? -45.132 -2.502 0.558 1.00 62.75 ? 287 TRP A CB 1 ATOM 2263 C CG . TRP A 1 287 ? -44.343 -3.327 -0.450 1.00 64.98 ? 287 TRP A CG 1 ATOM 2264 C CD1 . TRP A 1 287 ? -44.808 -4.369 -1.211 1.00 66.27 ? 287 TRP A CD1 1 ATOM 2265 C CD2 . TRP A 1 287 ? -42.942 -3.196 -0.770 1.00 66.38 ? 287 TRP A CD2 1 ATOM 2266 N NE1 . TRP A 1 287 ? -43.791 -4.874 -2.000 1.00 66.84 ? 287 TRP A NE1 1 ATOM 2267 C CE2 . TRP A 1 287 ? -42.639 -4.177 -1.748 1.00 66.64 ? 287 TRP A CE2 1 ATOM 2268 C CE3 . TRP A 1 287 ? -41.921 -2.338 -0.337 1.00 66.05 ? 287 TRP A CE3 1 ATOM 2269 C CZ2 . TRP A 1 287 ? -41.354 -4.322 -2.302 1.00 67.02 ? 287 TRP A CZ2 1 ATOM 2270 C CZ3 . TRP A 1 287 ? -40.642 -2.482 -0.892 1.00 66.15 ? 287 TRP A CZ3 1 ATOM 2271 C CH2 . TRP A 1 287 ? -40.374 -3.469 -1.862 1.00 66.27 ? 287 TRP A CH2 1 ATOM 2272 N N . ASN A 1 288 ? -47.534 -2.514 2.671 1.00 60.50 ? 288 ASN A N 1 ATOM 2273 C CA . ASN A 1 288 ? -48.142 -1.916 3.839 1.00 59.60 ? 288 ASN A CA 1 ATOM 2274 C C . ASN A 1 288 ? -47.070 -1.619 4.902 1.00 59.01 ? 288 ASN A C 1 ATOM 2275 O O . ASN A 1 288 ? -45.854 -1.710 4.614 1.00 58.67 ? 288 ASN A O 1 ATOM 2276 C CB . ASN A 1 288 ? -49.059 -2.938 4.497 1.00 59.83 ? 288 ASN A CB 1 ATOM 2277 C CG . ASN A 1 288 ? -48.454 -4.316 4.523 1.00 59.91 ? 288 ASN A CG 1 ATOM 2278 O OD1 . ASN A 1 288 ? -47.882 -4.723 5.526 1.00 59.68 ? 288 ASN A OD1 1 ATOM 2279 N ND2 . ASN A 1 288 ? -48.564 -5.044 3.409 1.00 60.37 ? 288 ASN A ND2 1 ATOM 2280 N N . GLY A 1 289 ? -47.525 -1.235 6.106 1.00 57.45 ? 289 GLY A N 1 ATOM 2281 C CA . GLY A 1 289 ? -46.649 -0.756 7.187 1.00 56.03 ? 289 GLY A CA 1 ATOM 2282 C C . GLY A 1 289 ? -45.377 -1.564 7.387 1.00 54.91 ? 289 GLY A C 1 ATOM 2283 O O . GLY A 1 289 ? -44.270 -1.021 7.405 1.00 54.37 ? 289 GLY A O 1 ATOM 2284 N N . GLU A 1 290 ? -45.568 -2.876 7.508 1.00 53.69 ? 290 GLU A N 1 ATOM 2285 C CA . GLU A 1 290 ? -44.506 -3.825 7.734 1.00 52.33 ? 290 GLU A CA 1 ATOM 2286 C C . GLU A 1 290 ? -43.546 -3.983 6.554 1.00 51.09 ? 290 GLU A C 1 ATOM 2287 O O . GLU A 1 290 ? -42.347 -3.756 6.703 1.00 50.86 ? 290 GLU A O 1 ATOM 2288 C CB . GLU A 1 290 ? -45.102 -5.168 8.100 1.00 52.47 ? 290 GLU A CB 1 ATOM 2289 C CG . GLU A 1 290 ? -44.199 -5.990 8.994 1.00 54.49 ? 290 GLU A CG 1 ATOM 2290 C CD . GLU A 1 290 ? -44.393 -5.700 10.460 1.00 57.30 ? 290 GLU A CD 1 ATOM 2291 O OE1 . GLU A 1 290 ? -45.364 -4.982 10.806 1.00 58.98 ? 290 GLU A OE1 1 ATOM 2292 O OE2 . GLU A 1 290 ? -43.580 -6.205 11.271 1.00 57.77 ? 290 GLU A OE2 1 ATOM 2293 N N . LYS A 1 291 ? -44.052 -4.373 5.392 1.00 49.56 ? 291 LYS A N 1 ATOM 2294 C CA . LYS A 1 291 ? -43.159 -4.678 4.265 1.00 48.15 ? 291 LYS A CA 1 ATOM 2295 C C . LYS A 1 291 ? -42.165 -3.562 3.993 1.00 47.44 ? 291 LYS A C 1 ATOM 2296 O O . LYS A 1 291 ? -40.997 -3.829 3.660 1.00 47.43 ? 291 LYS A O 1 ATOM 2297 C CB . LYS A 1 291 ? -43.932 -5.018 2.992 1.00 47.93 ? 291 LYS A CB 1 ATOM 2298 C CG . LYS A 1 291 ? -43.374 -6.210 2.238 1.00 48.12 ? 291 LYS A CG 1 ATOM 2299 C CD . LYS A 1 291 ? -43.586 -7.516 3.047 1.00 48.52 ? 291 LYS A CD 1 ATOM 2300 C CE . LYS A 1 291 ? -43.264 -8.758 2.225 1.00 48.99 ? 291 LYS A CE 1 ATOM 2301 N NZ . LYS A 1 291 ? -43.701 -10.042 2.868 1.00 48.38 ? 291 LYS A NZ 1 ATOM 2302 N N . LEU A 1 292 ? -42.617 -2.316 4.139 1.00 46.15 ? 292 LEU A N 1 ATOM 2303 C CA . LEU A 1 292 ? -41.726 -1.162 3.986 1.00 45.34 ? 292 LEU A CA 1 ATOM 2304 C C . LEU A 1 292 ? -40.717 -1.048 5.156 1.00 44.35 ? 292 LEU A C 1 ATOM 2305 O O . LEU A 1 292 ? -39.520 -0.873 4.937 1.00 43.94 ? 292 LEU A O 1 ATOM 2306 C CB . LEU A 1 292 ? -42.527 0.134 3.805 1.00 45.17 ? 292 LEU A CB 1 ATOM 2307 C CG . LEU A 1 292 ? -43.108 0.365 2.411 1.00 45.56 ? 292 LEU A CG 1 ATOM 2308 C CD1 . LEU A 1 292 ? -44.146 1.440 2.487 1.00 45.66 ? 292 LEU A CD1 1 ATOM 2309 C CD2 . LEU A 1 292 ? -42.016 0.740 1.370 1.00 46.65 ? 292 LEU A CD2 1 ATOM 2310 N N . TYR A 1 293 ? -41.222 -1.145 6.381 1.00 43.19 ? 293 TYR A N 1 ATOM 2311 C CA . TYR A 1 293 ? -40.378 -1.159 7.557 1.00 43.15 ? 293 TYR A CA 1 ATOM 2312 C C . TYR A 1 293 ? -39.317 -2.260 7.458 1.00 42.63 ? 293 TYR A C 1 ATOM 2313 O O . TYR A 1 293 ? -38.124 -1.952 7.385 1.00 42.75 ? 293 TYR A O 1 ATOM 2314 C CB . TYR A 1 293 ? -41.220 -1.364 8.814 1.00 42.98 ? 293 TYR A CB 1 ATOM 2315 C CG . TYR A 1 293 ? -40.432 -1.738 10.046 1.00 43.55 ? 293 TYR A CG 1 ATOM 2316 C CD1 . TYR A 1 293 ? -39.639 -0.801 10.711 1.00 44.04 ? 293 TYR A CD1 1 ATOM 2317 C CD2 . TYR A 1 293 ? -40.492 -3.029 10.557 1.00 44.36 ? 293 TYR A CD2 1 ATOM 2318 C CE1 . TYR A 1 293 ? -38.923 -1.153 11.862 1.00 45.05 ? 293 TYR A CE1 1 ATOM 2319 C CE2 . TYR A 1 293 ? -39.782 -3.399 11.702 1.00 44.69 ? 293 TYR A CE2 1 ATOM 2320 C CZ . TYR A 1 293 ? -39.000 -2.464 12.351 1.00 45.87 ? 293 TYR A CZ 1 ATOM 2321 O OH . TYR A 1 293 ? -38.325 -2.842 13.499 1.00 46.69 ? 293 TYR A OH 1 ATOM 2322 N N . GLN A 1 294 ? -39.774 -3.519 7.428 1.00 41.34 ? 294 GLN A N 1 ATOM 2323 C CA . GLN A 1 294 ? -38.906 -4.691 7.346 1.00 40.12 ? 294 GLN A CA 1 ATOM 2324 C C . GLN A 1 294 ? -37.912 -4.645 6.172 1.00 39.76 ? 294 GLN A C 1 ATOM 2325 O O . GLN A 1 294 ? -36.757 -5.073 6.308 1.00 39.57 ? 294 GLN A O 1 ATOM 2326 C CB . GLN A 1 294 ? -39.736 -5.977 7.308 1.00 39.90 ? 294 GLN A CB 1 ATOM 2327 C CG . GLN A 1 294 ? -40.665 -6.170 8.496 1.00 38.48 ? 294 GLN A CG 1 ATOM 2328 C CD . GLN A 1 294 ? -39.965 -6.711 9.724 1.00 41.43 ? 294 GLN A CD 1 ATOM 2329 O OE1 . GLN A 1 294 ? -38.795 -7.125 9.653 1.00 41.46 ? 294 GLN A OE1 1 ATOM 2330 N NE2 . GLN A 1 294 ? -40.677 -6.714 10.879 1.00 39.50 ? 294 GLN A NE2 1 ATOM 2331 N N . GLU A 1 295 ? -38.347 -4.110 5.038 1.00 39.01 ? 295 GLU A N 1 ATOM 2332 C CA . GLU A 1 295 ? -37.522 -4.125 3.834 1.00 38.39 ? 295 GLU A CA 1 ATOM 2333 C C . GLU A 1 295 ? -36.474 -3.034 3.827 1.00 38.03 ? 295 GLU A C 1 ATOM 2334 O O . GLU A 1 295 ? -35.502 -3.098 3.054 1.00 37.86 ? 295 GLU A O 1 ATOM 2335 C CB . GLU A 1 295 ? -38.400 -3.989 2.591 1.00 38.98 ? 295 GLU A CB 1 ATOM 2336 C CG . GLU A 1 295 ? -39.076 -5.298 2.138 1.00 40.25 ? 295 GLU A CG 1 ATOM 2337 C CD . GLU A 1 295 ? -38.175 -6.156 1.275 1.00 40.14 ? 295 GLU A CD 1 ATOM 2338 O OE1 . GLU A 1 295 ? -38.334 -7.392 1.279 1.00 37.93 ? 295 GLU A OE1 1 ATOM 2339 O OE2 . GLU A 1 295 ? -37.285 -5.586 0.609 1.00 44.36 ? 295 GLU A OE2 1 ATOM 2340 N N . ALA A 1 296 ? -36.686 -1.998 4.642 1.00 37.15 ? 296 ALA A N 1 ATOM 2341 C CA . ALA A 1 296 ? -35.687 -0.939 4.768 1.00 36.13 ? 296 ALA A CA 1 ATOM 2342 C C . ALA A 1 296 ? -34.707 -1.329 5.887 1.00 35.75 ? 296 ALA A C 1 ATOM 2343 O O . ALA A 1 296 ? -33.489 -1.223 5.725 1.00 35.56 ? 296 ALA A O 1 ATOM 2344 C CB . ALA A 1 296 ? -36.348 0.379 5.034 1.00 36.08 ? 296 ALA A CB 1 ATOM 2345 N N . ARG A 1 297 ? -35.271 -1.805 6.998 1.00 35.30 ? 297 ARG A N 1 ATOM 2346 C CA . ARG A 1 297 ? -34.550 -2.515 8.062 1.00 35.47 ? 297 ARG A CA 1 ATOM 2347 C C . ARG A 1 297 ? -33.488 -3.500 7.556 1.00 35.95 ? 297 ARG A C 1 ATOM 2348 O O . ARG A 1 297 ? -32.304 -3.414 7.941 1.00 36.86 ? 297 ARG A O 1 ATOM 2349 C CB . ARG A 1 297 ? -35.550 -3.263 8.920 1.00 34.72 ? 297 ARG A CB 1 ATOM 2350 C CG . ARG A 1 297 ? -34.935 -4.108 9.996 1.00 33.27 ? 297 ARG A CG 1 ATOM 2351 C CD . ARG A 1 297 ? -35.995 -4.512 10.995 1.00 30.16 ? 297 ARG A CD 1 ATOM 2352 N NE . ARG A 1 297 ? -35.403 -5.235 12.105 1.00 32.53 ? 297 ARG A NE 1 ATOM 2353 C CZ . ARG A 1 297 ? -35.396 -6.559 12.251 1.00 32.31 ? 297 ARG A CZ 1 ATOM 2354 N NH1 . ARG A 1 297 ? -35.980 -7.351 11.363 1.00 32.40 ? 297 ARG A NH1 1 ATOM 2355 N NH2 . ARG A 1 297 ? -34.794 -7.095 13.304 1.00 34.46 ? 297 ARG A NH2 1 ATOM 2356 N N . LYS A 1 298 ? -33.939 -4.428 6.704 1.00 36.19 ? 298 LYS A N 1 ATOM 2357 C CA . LYS A 1 298 ? -33.107 -5.388 5.985 1.00 35.28 ? 298 LYS A CA 1 ATOM 2358 C C . LYS A 1 298 ? -31.988 -4.704 5.203 1.00 34.51 ? 298 LYS A C 1 ATOM 2359 O O . LYS A 1 298 ? -30.837 -5.129 5.255 1.00 34.93 ? 298 LYS A O 1 ATOM 2360 C CB . LYS A 1 298 ? -33.984 -6.226 5.065 1.00 35.40 ? 298 LYS A CB 1 ATOM 2361 C CG . LYS A 1 298 ? -33.268 -7.384 4.391 1.00 36.13 ? 298 LYS A CG 1 ATOM 2362 C CD . LYS A 1 298 ? -34.249 -8.457 3.900 1.00 36.32 ? 298 LYS A CD 1 ATOM 2363 C CE . LYS A 1 298 ? -33.620 -9.220 2.710 1.00 37.50 ? 298 LYS A CE 1 ATOM 2364 N NZ . LYS A 1 298 ? -33.888 -10.704 2.763 1.00 38.10 ? 298 LYS A NZ 1 ATOM 2365 N N . ILE A 1 299 ? -32.302 -3.616 4.515 1.00 33.82 ? 299 ILE A N 1 ATOM 2366 C CA . ILE A 1 299 ? -31.247 -2.855 3.833 1.00 32.53 ? 299 ILE A CA 1 ATOM 2367 C C . ILE A 1 299 ? -30.348 -2.126 4.841 1.00 31.58 ? 299 ILE A C 1 ATOM 2368 O O . ILE A 1 299 ? -29.136 -2.005 4.622 1.00 31.10 ? 299 ILE A O 1 ATOM 2369 C CB . ILE A 1 299 ? -31.794 -1.828 2.789 1.00 32.73 ? 299 ILE A CB 1 ATOM 2370 C CG1 . ILE A 1 299 ? -33.004 -2.391 2.037 1.00 33.62 ? 299 ILE A CG1 1 ATOM 2371 C CG2 . ILE A 1 299 ? -30.651 -1.384 1.820 1.00 31.26 ? 299 ILE A CG2 1 ATOM 2372 C CD1 . ILE A 1 299 ? -33.448 -1.521 0.773 1.00 35.17 ? 299 ILE A CD1 1 ATOM 2373 N N . LEU A 1 300 ? -30.923 -1.633 5.943 1.00 30.82 ? 300 LEU A N 1 ATOM 2374 C CA . LEU A 1 300 ? -30.073 -0.930 6.917 1.00 30.04 ? 300 LEU A CA 1 ATOM 2375 C C . LEU A 1 300 ? -29.019 -1.869 7.504 1.00 30.24 ? 300 LEU A C 1 ATOM 2376 O O . LEU A 1 300 ? -27.848 -1.459 7.689 1.00 30.02 ? 300 LEU A O 1 ATOM 2377 C CB . LEU A 1 300 ? -30.863 -0.225 8.000 1.00 29.10 ? 300 LEU A CB 1 ATOM 2378 C CG . LEU A 1 300 ? -30.016 0.890 8.633 1.00 28.01 ? 300 LEU A CG 1 ATOM 2379 C CD1 . LEU A 1 300 ? -29.385 1.832 7.622 1.00 23.38 ? 300 LEU A CD1 1 ATOM 2380 C CD2 . LEU A 1 300 ? -30.829 1.674 9.658 1.00 26.05 ? 300 LEU A CD2 1 ATOM 2381 N N . GLY A 1 301 ? -29.428 -3.136 7.725 1.00 29.68 ? 301 GLY A N 1 ATOM 2382 C CA . GLY A 1 301 ? -28.550 -4.179 8.282 1.00 28.73 ? 301 GLY A CA 1 ATOM 2383 C C . GLY A 1 301 ? -27.378 -4.485 7.372 1.00 28.68 ? 301 GLY A C 1 ATOM 2384 O O . GLY A 1 301 ? -26.227 -4.581 7.815 1.00 29.25 ? 301 GLY A O 1 ATOM 2385 N N . ALA A 1 302 ? -27.669 -4.623 6.087 1.00 28.43 ? 302 ALA A N 1 ATOM 2386 C CA . ALA A 1 302 ? -26.679 -5.058 5.123 1.00 28.63 ? 302 ALA A CA 1 ATOM 2387 C C . ALA A 1 302 ? -25.593 -4.005 4.964 1.00 28.97 ? 302 ALA A C 1 ATOM 2388 O O . ALA A 1 302 ? -24.415 -4.346 4.810 1.00 29.93 ? 302 ALA A O 1 ATOM 2389 C CB . ALA A 1 302 ? -27.336 -5.355 3.802 1.00 28.28 ? 302 ALA A CB 1 ATOM 2390 N N . PHE A 1 303 ? -26.002 -2.736 4.998 1.00 28.17 ? 303 PHE A N 1 ATOM 2391 C CA . PHE A 1 303 ? -25.109 -1.592 4.885 1.00 27.90 ? 303 PHE A CA 1 ATOM 2392 C C . PHE A 1 303 ? -24.222 -1.574 6.103 1.00 27.66 ? 303 PHE A C 1 ATOM 2393 O O . PHE A 1 303 ? -22.998 -1.435 6.007 1.00 27.98 ? 303 PHE A O 1 ATOM 2394 C CB . PHE A 1 303 ? -25.959 -0.324 4.854 1.00 28.97 ? 303 PHE A CB 1 ATOM 2395 C CG . PHE A 1 303 ? -25.196 0.957 5.010 1.00 28.17 ? 303 PHE A CG 1 ATOM 2396 C CD1 . PHE A 1 303 ? -24.698 1.618 3.896 1.00 29.42 ? 303 PHE A CD1 1 ATOM 2397 C CD2 . PHE A 1 303 ? -25.029 1.531 6.255 1.00 30.28 ? 303 PHE A CD2 1 ATOM 2398 C CE1 . PHE A 1 303 ? -24.002 2.830 4.025 1.00 31.04 ? 303 PHE A CE1 1 ATOM 2399 C CE2 . PHE A 1 303 ? -24.348 2.730 6.406 1.00 30.84 ? 303 PHE A CE2 1 ATOM 2400 C CZ . PHE A 1 303 ? -23.842 3.388 5.280 1.00 32.25 ? 303 PHE A CZ 1 ATOM 2401 N N . ILE A 1 304 ? -24.824 -1.739 7.268 1.00 27.20 ? 304 ILE A N 1 ATOM 2402 C CA . ILE A 1 304 ? -23.981 -1.869 8.434 1.00 27.16 ? 304 ILE A CA 1 ATOM 2403 C C . ILE A 1 304 ? -22.897 -2.935 8.219 1.00 27.35 ? 304 ILE A C 1 ATOM 2404 O O . ILE A 1 304 ? -21.695 -2.646 8.429 1.00 26.39 ? 304 ILE A O 1 ATOM 2405 C CB . ILE A 1 304 ? -24.756 -2.050 9.739 1.00 26.69 ? 304 ILE A CB 1 ATOM 2406 C CG1 . ILE A 1 304 ? -25.524 -0.747 10.033 1.00 25.01 ? 304 ILE A CG1 1 ATOM 2407 C CG2 . ILE A 1 304 ? -23.748 -2.394 10.859 1.00 27.28 ? 304 ILE A CG2 1 ATOM 2408 C CD1 . ILE A 1 304 ? -26.219 -0.662 11.390 1.00 23.46 ? 304 ILE A CD1 1 ATOM 2409 N N . GLN A 1 305 ? -23.313 -4.123 7.751 1.00 28.33 ? 305 GLN A N 1 ATOM 2410 C CA . GLN A 1 305 ? -22.380 -5.249 7.546 1.00 29.31 ? 305 GLN A CA 1 ATOM 2411 C C . GLN A 1 305 ? -21.317 -4.920 6.499 1.00 29.62 ? 305 GLN A C 1 ATOM 2412 O O . GLN A 1 305 ? -20.122 -5.158 6.719 1.00 30.53 ? 305 GLN A O 1 ATOM 2413 C CB . GLN A 1 305 ? -23.124 -6.562 7.209 1.00 30.36 ? 305 GLN A CB 1 ATOM 2414 C CG . GLN A 1 305 ? -24.123 -7.081 8.311 1.00 30.40 ? 305 GLN A CG 1 ATOM 2415 C CD . GLN A 1 305 ? -24.898 -8.343 7.899 1.00 33.14 ? 305 GLN A CD 1 ATOM 2416 O OE1 . GLN A 1 305 ? -25.076 -8.618 6.711 1.00 30.47 ? 305 GLN A OE1 1 ATOM 2417 N NE2 . GLN A 1 305 ? -25.373 -9.113 8.893 1.00 34.23 ? 305 GLN A NE2 1 ATOM 2418 N N . ILE A 1 306 ? -21.725 -4.318 5.385 1.00 29.87 ? 306 ILE A N 1 ATOM 2419 C CA . ILE A 1 306 ? -20.790 -4.042 4.288 1.00 29.78 ? 306 ILE A CA 1 ATOM 2420 C C . ILE A 1 306 ? -19.754 -3.006 4.681 1.00 29.56 ? 306 ILE A C 1 ATOM 2421 O O . ILE A 1 306 ? -18.576 -3.137 4.338 1.00 30.03 ? 306 ILE A O 1 ATOM 2422 C CB . ILE A 1 306 ? -21.516 -3.625 3.003 1.00 30.26 ? 306 ILE A CB 1 ATOM 2423 C CG1 . ILE A 1 306 ? -22.447 -4.742 2.542 1.00 30.99 ? 306 ILE A CG1 1 ATOM 2424 C CG2 . ILE A 1 306 ? -20.515 -3.353 1.874 1.00 31.58 ? 306 ILE A CG2 1 ATOM 2425 C CD1 . ILE A 1 306 ? -23.519 -4.299 1.509 1.00 33.57 ? 306 ILE A CD1 1 ATOM 2426 N N . ILE A 1 307 ? -20.178 -1.989 5.426 1.00 29.39 ? 307 ILE A N 1 ATOM 2427 C CA . ILE A 1 307 ? -19.242 -0.947 5.870 1.00 28.86 ? 307 ILE A CA 1 ATOM 2428 C C . ILE A 1 307 ? -18.216 -1.477 6.889 1.00 27.55 ? 307 ILE A C 1 ATOM 2429 O O . ILE A 1 307 ? -17.008 -1.164 6.829 1.00 27.33 ? 307 ILE A O 1 ATOM 2430 C CB . ILE A 1 307 ? -19.981 0.317 6.374 1.00 29.13 ? 307 ILE A CB 1 ATOM 2431 C CG1 . ILE A 1 307 ? -20.932 0.835 5.283 1.00 31.33 ? 307 ILE A CG1 1 ATOM 2432 C CG2 . ILE A 1 307 ? -18.987 1.424 6.756 1.00 28.70 ? 307 ILE A CG2 1 ATOM 2433 C CD1 . ILE A 1 307 ? -20.257 1.122 3.863 1.00 33.91 ? 307 ILE A CD1 1 ATOM 2434 N N . THR A 1 308 ? -18.716 -2.312 7.782 1.00 25.58 ? 308 THR A N 1 ATOM 2435 C CA . THR A 1 308 ? -17.915 -2.920 8.817 1.00 24.47 ? 308 THR A CA 1 ATOM 2436 C C . THR A 1 308 ? -16.935 -3.897 8.224 1.00 24.54 ? 308 THR A C 1 ATOM 2437 O O . THR A 1 308 ? -15.749 -3.897 8.571 1.00 24.64 ? 308 THR A O 1 ATOM 2438 C CB . THR A 1 308 ? -18.804 -3.710 9.781 1.00 24.15 ? 308 THR A CB 1 ATOM 2439 O OG1 . THR A 1 308 ? -19.785 -2.828 10.344 1.00 21.42 ? 308 THR A OG1 1 ATOM 2440 C CG2 . THR A 1 308 ? -17.955 -4.381 10.873 1.00 22.51 ? 308 THR A CG2 1 ATOM 2441 N N . PHE A 1 309 ? -17.445 -4.750 7.356 1.00 24.45 ? 309 PHE A N 1 ATOM 2442 C CA . PHE A 1 309 ? -16.629 -5.804 6.818 1.00 25.49 ? 309 PHE A CA 1 ATOM 2443 C C . PHE A 1 309 ? -15.774 -5.364 5.624 1.00 25.93 ? 309 PHE A C 1 ATOM 2444 O O . PHE A 1 309 ? -14.618 -5.757 5.550 1.00 25.84 ? 309 PHE A O 1 ATOM 2445 C CB . PHE A 1 309 ? -17.452 -7.071 6.582 1.00 25.39 ? 309 PHE A CB 1 ATOM 2446 C CG . PHE A 1 309 ? -17.590 -7.953 7.822 1.00 25.74 ? 309 PHE A CG 1 ATOM 2447 C CD1 . PHE A 1 309 ? -18.390 -7.566 8.898 1.00 25.03 ? 309 PHE A CD1 1 ATOM 2448 C CD2 . PHE A 1 309 ? -16.915 -9.175 7.909 1.00 25.76 ? 309 PHE A CD2 1 ATOM 2449 C CE1 . PHE A 1 309 ? -18.506 -8.389 10.027 1.00 25.44 ? 309 PHE A CE1 1 ATOM 2450 C CE2 . PHE A 1 309 ? -17.035 -9.999 9.022 1.00 22.34 ? 309 PHE A CE2 1 ATOM 2451 C CZ . PHE A 1 309 ? -17.833 -9.608 10.083 1.00 24.14 ? 309 PHE A CZ 1 ATOM 2452 N N . ARG A 1 310 ? -16.303 -4.519 4.734 1.00 26.88 ? 310 ARG A N 1 ATOM 2453 C CA . ARG A 1 310 ? -15.480 -4.004 3.623 1.00 27.40 ? 310 ARG A CA 1 ATOM 2454 C C . ARG A 1 310 ? -14.535 -2.863 3.993 1.00 27.13 ? 310 ARG A C 1 ATOM 2455 O O . ARG A 1 310 ? -13.354 -2.925 3.658 1.00 27.24 ? 310 ARG A O 1 ATOM 2456 C CB . ARG A 1 310 ? -16.311 -3.658 2.386 1.00 27.49 ? 310 ARG A CB 1 ATOM 2457 C CG . ARG A 1 310 ? -15.454 -3.238 1.148 1.00 28.47 ? 310 ARG A CG 1 ATOM 2458 C CD . ARG A 1 310 ? -16.279 -2.376 0.192 1.00 29.24 ? 310 ARG A CD 1 ATOM 2459 N NE . ARG A 1 310 ? -16.637 -1.074 0.769 1.00 28.46 ? 310 ARG A NE 1 ATOM 2460 C CZ . ARG A 1 310 ? -17.791 -0.443 0.563 1.00 27.35 ? 310 ARG A CZ 1 ATOM 2461 N NH1 . ARG A 1 310 ? -18.736 -0.965 -0.215 1.00 26.36 ? 310 ARG A NH1 1 ATOM 2462 N NH2 . ARG A 1 310 ? -17.998 0.731 1.133 1.00 23.96 ? 310 ARG A NH2 1 ATOM 2463 N N . ASP A 1 311 ? -15.030 -1.848 4.703 1.00 27.40 ? 311 ASP A N 1 ATOM 2464 C CA . ASP A 1 311 ? -14.222 -0.630 4.982 1.00 27.59 ? 311 ASP A CA 1 ATOM 2465 C C . ASP A 1 311 ? -13.514 -0.604 6.330 1.00 27.19 ? 311 ASP A C 1 ATOM 2466 O O . ASP A 1 311 ? -12.367 -0.104 6.432 1.00 27.60 ? 311 ASP A O 1 ATOM 2467 C CB . ASP A 1 311 ? -15.075 0.644 4.879 1.00 28.18 ? 311 ASP A CB 1 ATOM 2468 C CG . ASP A 1 311 ? -15.750 0.799 3.539 1.00 29.78 ? 311 ASP A CG 1 ATOM 2469 O OD1 . ASP A 1 311 ? -15.181 0.365 2.500 1.00 33.15 ? 311 ASP A OD1 1 ATOM 2470 O OD2 . ASP A 1 311 ? -16.865 1.359 3.535 1.00 30.93 ? 311 ASP A OD2 1 ATOM 2471 N N . TYR A 1 312 ? -14.203 -1.107 7.361 1.00 25.87 ? 312 TYR A N 1 ATOM 2472 C CA . TYR A 1 312 ? -13.747 -0.959 8.731 1.00 24.40 ? 312 TYR A CA 1 ATOM 2473 C C . TYR A 1 312 ? -12.798 -2.067 9.210 1.00 24.44 ? 312 TYR A C 1 ATOM 2474 O O . TYR A 1 312 ? -11.630 -1.787 9.547 1.00 24.04 ? 312 TYR A O 1 ATOM 2475 C CB . TYR A 1 312 ? -14.949 -0.805 9.674 1.00 24.71 ? 312 TYR A CB 1 ATOM 2476 C CG . TYR A 1 312 ? -14.565 -0.720 11.134 1.00 21.41 ? 312 TYR A CG 1 ATOM 2477 C CD1 . TYR A 1 312 ? -14.143 0.494 11.706 1.00 20.26 ? 312 TYR A CD1 1 ATOM 2478 C CD2 . TYR A 1 312 ? -14.641 -1.838 11.938 1.00 18.35 ? 312 TYR A CD2 1 ATOM 2479 C CE1 . TYR A 1 312 ? -13.773 0.560 13.066 1.00 21.17 ? 312 TYR A CE1 1 ATOM 2480 C CE2 . TYR A 1 312 ? -14.294 -1.796 13.291 1.00 19.28 ? 312 TYR A CE2 1 ATOM 2481 C CZ . TYR A 1 312 ? -13.866 -0.607 13.847 1.00 21.52 ? 312 TYR A CZ 1 ATOM 2482 O OH . TYR A 1 312 ? -13.532 -0.587 15.175 1.00 23.45 ? 312 TYR A OH 1 ATOM 2483 N N . LEU A 1 313 ? -13.268 -3.318 9.234 1.00 23.53 ? 313 LEU A N 1 ATOM 2484 C CA . LEU A 1 313 ? -12.401 -4.420 9.709 1.00 23.90 ? 313 LEU A CA 1 ATOM 2485 C C . LEU A 1 313 ? -10.980 -4.460 9.103 1.00 23.85 ? 313 LEU A C 1 ATOM 2486 O O . LEU A 1 313 ? -10.008 -4.646 9.867 1.00 24.65 ? 313 LEU A O 1 ATOM 2487 C CB . LEU A 1 313 ? -13.076 -5.795 9.612 1.00 23.64 ? 313 LEU A CB 1 ATOM 2488 C CG . LEU A 1 313 ? -14.306 -5.901 10.525 1.00 24.91 ? 313 LEU A CG 1 ATOM 2489 C CD1 . LEU A 1 313 ? -14.925 -7.290 10.438 1.00 22.72 ? 313 LEU A CD1 1 ATOM 2490 C CD2 . LEU A 1 313 ? -13.935 -5.504 12.000 1.00 20.69 ? 313 LEU A CD2 1 ATOM 2491 N N . PRO A 1 314 ? -10.847 -4.268 7.759 1.00 23.73 ? 314 PRO A N 1 ATOM 2492 C CA . PRO A 1 314 ? -9.511 -4.406 7.136 1.00 23.70 ? 314 PRO A CA 1 ATOM 2493 C C . PRO A 1 314 ? -8.482 -3.437 7.661 1.00 22.66 ? 314 PRO A C 1 ATOM 2494 O O . PRO A 1 314 ? -7.317 -3.732 7.633 1.00 23.35 ? 314 PRO A O 1 ATOM 2495 C CB . PRO A 1 314 ? -9.778 -4.175 5.636 1.00 23.39 ? 314 PRO A CB 1 ATOM 2496 C CG . PRO A 1 314 ? -11.189 -4.685 5.460 1.00 24.15 ? 314 PRO A CG 1 ATOM 2497 C CD . PRO A 1 314 ? -11.893 -4.150 6.719 1.00 23.62 ? 314 PRO A CD 1 ATOM 2498 N N . ILE A 1 315 ? -8.909 -2.309 8.175 1.00 22.41 ? 315 ILE A N 1 ATOM 2499 C CA . ILE A 1 315 ? -7.969 -1.383 8.774 1.00 21.88 ? 315 ILE A CA 1 ATOM 2500 C C . ILE A 1 315 ? -7.862 -1.472 10.294 1.00 22.42 ? 315 ILE A C 1 ATOM 2501 O O . ILE A 1 315 ? -6.951 -0.897 10.859 1.00 22.46 ? 315 ILE A O 1 ATOM 2502 C CB . ILE A 1 315 ? -8.199 0.053 8.316 1.00 21.71 ? 315 ILE A CB 1 ATOM 2503 C CG1 . ILE A 1 315 ? -9.603 0.508 8.692 1.00 19.16 ? 315 ILE A CG1 1 ATOM 2504 C CG2 . ILE A 1 315 ? -7.991 0.151 6.797 1.00 22.01 ? 315 ILE A CG2 1 ATOM 2505 C CD1 . ILE A 1 315 ? -9.906 1.896 8.302 1.00 16.57 ? 315 ILE A CD1 1 ATOM 2506 N N . VAL A 1 316 ? -8.771 -2.197 10.953 1.00 23.23 ? 316 VAL A N 1 ATOM 2507 C CA . VAL A 1 316 ? -8.515 -2.601 12.348 1.00 23.19 ? 316 VAL A CA 1 ATOM 2508 C C . VAL A 1 316 ? -7.482 -3.739 12.379 1.00 23.75 ? 316 VAL A C 1 ATOM 2509 O O . VAL A 1 316 ? -6.529 -3.681 13.132 1.00 22.68 ? 316 VAL A O 1 ATOM 2510 C CB . VAL A 1 316 ? -9.810 -3.045 13.142 1.00 22.97 ? 316 VAL A CB 1 ATOM 2511 C CG1 . VAL A 1 316 ? -9.444 -3.533 14.535 1.00 18.38 ? 316 VAL A CG1 1 ATOM 2512 C CG2 . VAL A 1 316 ? -10.819 -1.918 13.198 1.00 21.64 ? 316 VAL A CG2 1 ATOM 2513 N N . LEU A 1 317 ? -7.710 -4.760 11.548 1.00 25.51 ? 317 LEU A N 1 ATOM 2514 C CA . LEU A 1 317 ? -7.005 -6.052 11.640 1.00 26.83 ? 317 LEU A CA 1 ATOM 2515 C C . LEU A 1 317 ? -5.786 -6.133 10.738 1.00 27.80 ? 317 LEU A C 1 ATOM 2516 O O . LEU A 1 317 ? -4.899 -6.945 11.000 1.00 29.35 ? 317 LEU A O 1 ATOM 2517 C CB . LEU A 1 317 ? -7.951 -7.250 11.383 1.00 26.47 ? 317 LEU A CB 1 ATOM 2518 C CG . LEU A 1 317 ? -9.207 -7.444 12.267 1.00 27.32 ? 317 LEU A CG 1 ATOM 2519 C CD1 . LEU A 1 317 ? -10.028 -8.638 11.835 1.00 27.26 ? 317 LEU A CD1 1 ATOM 2520 C CD2 . LEU A 1 317 ? -8.901 -7.591 13.739 1.00 26.69 ? 317 LEU A CD2 1 ATOM 2521 N N . GLY A 1 318 ? -5.735 -5.310 9.690 1.00 28.49 ? 318 GLY A N 1 ATOM 2522 C CA . GLY A 1 318 ? -4.541 -5.191 8.829 1.00 30.06 ? 318 GLY A CA 1 ATOM 2523 C C . GLY A 1 318 ? -4.037 -6.507 8.266 1.00 31.11 ? 318 GLY A C 1 ATOM 2524 O O . GLY A 1 318 ? -4.805 -7.279 7.718 1.00 30.74 ? 318 GLY A O 1 ATOM 2525 N N . SER A 1 319 ? -2.753 -6.797 8.429 1.00 32.62 ? 319 SER A N 1 ATOM 2526 C CA . SER A 1 319 ? -2.204 -8.011 7.816 1.00 34.69 ? 319 SER A CA 1 ATOM 2527 C C . SER A 1 319 ? -2.982 -9.261 8.247 1.00 35.74 ? 319 SER A C 1 ATOM 2528 O O . SER A 1 319 ? -3.115 -10.245 7.489 1.00 36.85 ? 319 SER A O 1 ATOM 2529 C CB . SER A 1 319 ? -0.703 -8.155 8.097 1.00 34.62 ? 319 SER A CB 1 ATOM 2530 O OG . SER A 1 319 ? -0.359 -8.009 9.479 1.00 36.81 ? 319 SER A OG 1 ATOM 2531 N N . GLU A 1 320 ? -3.520 -9.204 9.457 1.00 36.34 ? 320 GLU A N 1 ATOM 2532 C CA . GLU A 1 320 ? -4.207 -10.344 10.057 1.00 36.82 ? 320 GLU A CA 1 ATOM 2533 C C . GLU A 1 320 ? -5.610 -10.571 9.486 1.00 36.56 ? 320 GLU A C 1 ATOM 2534 O O . GLU A 1 320 ? -6.237 -11.592 9.777 1.00 37.18 ? 320 GLU A O 1 ATOM 2535 C CB . GLU A 1 320 ? -4.334 -10.104 11.554 1.00 37.39 ? 320 GLU A CB 1 ATOM 2536 C CG . GLU A 1 320 ? -3.027 -9.900 12.288 1.00 39.37 ? 320 GLU A CG 1 ATOM 2537 C CD . GLU A 1 320 ? -2.333 -11.209 12.618 1.00 42.50 ? 320 GLU A CD 1 ATOM 2538 O OE1 . GLU A 1 320 ? -2.848 -11.987 13.473 1.00 41.97 ? 320 GLU A OE1 1 ATOM 2539 O OE2 . GLU A 1 320 ? -1.269 -11.445 12.004 1.00 42.55 ? 320 GLU A OE2 1 ATOM 2540 N N . MET A 1 321 ? -6.099 -9.615 8.696 1.00 35.87 ? 321 MET A N 1 ATOM 2541 C CA . MET A 1 321 ? -7.470 -9.606 8.185 1.00 35.28 ? 321 MET A CA 1 ATOM 2542 C C . MET A 1 321 ? -7.986 -10.909 7.541 1.00 35.78 ? 321 MET A C 1 ATOM 2543 O O . MET A 1 321 ? -9.029 -11.439 7.961 1.00 35.94 ? 321 MET A O 1 ATOM 2544 C CB . MET A 1 321 ? -7.664 -8.438 7.206 1.00 34.76 ? 321 MET A CB 1 ATOM 2545 C CG . MET A 1 321 ? -9.052 -8.389 6.568 1.00 34.04 ? 321 MET A CG 1 ATOM 2546 S SD . MET A 1 321 ? -10.355 -8.015 7.772 1.00 34.10 ? 321 MET A SD 1 ATOM 2547 C CE . MET A 1 321 ? -11.839 -8.542 6.907 1.00 29.27 ? 321 MET A CE 1 ATOM 2548 N N . GLN A 1 322 ? -7.310 -11.385 6.492 1.00 35.87 ? 322 GLN A N 1 ATOM 2549 C CA . GLN A 1 322 ? -7.834 -12.481 5.665 1.00 36.13 ? 322 GLN A CA 1 ATOM 2550 C C . GLN A 1 322 ? -7.357 -13.795 6.273 1.00 36.23 ? 322 GLN A C 1 ATOM 2551 O O . GLN A 1 322 ? -7.754 -14.882 5.872 1.00 36.90 ? 322 GLN A O 1 ATOM 2552 C CB . GLN A 1 322 ? -7.399 -12.324 4.209 1.00 36.38 ? 322 GLN A CB 1 ATOM 2553 C CG . GLN A 1 322 ? -7.803 -10.967 3.537 1.00 38.86 ? 322 GLN A CG 1 ATOM 2554 C CD . GLN A 1 322 ? -8.875 -11.093 2.410 1.00 40.70 ? 322 GLN A CD 1 ATOM 2555 O OE1 . GLN A 1 322 ? -9.974 -10.536 2.509 1.00 41.76 ? 322 GLN A OE1 1 ATOM 2556 N NE2 . GLN A 1 322 ? -8.541 -11.816 1.346 1.00 39.45 ? 322 GLN A NE2 1 ATOM 2557 N N . LYS A 1 323 ? -6.506 -13.674 7.275 1.00 36.07 ? 323 LYS A N 1 ATOM 2558 C CA . LYS A 1 323 ? -6.069 -14.787 8.090 1.00 36.08 ? 323 LYS A CA 1 ATOM 2559 C C . LYS A 1 323 ? -7.257 -15.286 8.957 1.00 35.46 ? 323 LYS A C 1 ATOM 2560 O O . LYS A 1 323 ? -7.521 -16.469 9.029 1.00 35.70 ? 323 LYS A O 1 ATOM 2561 C CB . LYS A 1 323 ? -4.900 -14.254 8.937 1.00 36.62 ? 323 LYS A CB 1 ATOM 2562 C CG . LYS A 1 323 ? -4.068 -15.224 9.749 1.00 38.86 ? 323 LYS A CG 1 ATOM 2563 C CD . LYS A 1 323 ? -2.700 -14.573 9.983 1.00 42.14 ? 323 LYS A CD 1 ATOM 2564 C CE . LYS A 1 323 ? -1.814 -15.373 10.943 1.00 44.80 ? 323 LYS A CE 1 ATOM 2565 N NZ . LYS A 1 323 ? -2.534 -15.690 12.207 1.00 43.78 ? 323 LYS A NZ 1 ATOM 2566 N N . TRP A 1 324 ? -7.984 -14.365 9.590 1.00 34.77 ? 324 TRP A N 1 ATOM 2567 C CA . TRP A 1 324 ? -9.071 -14.698 10.528 1.00 33.27 ? 324 TRP A CA 1 ATOM 2568 C C . TRP A 1 324 ? -10.439 -14.692 9.889 1.00 33.01 ? 324 TRP A C 1 ATOM 2569 O O . TRP A 1 324 ? -11.339 -15.428 10.311 1.00 32.64 ? 324 TRP A O 1 ATOM 2570 C CB . TRP A 1 324 ? -9.080 -13.714 11.696 1.00 32.90 ? 324 TRP A CB 1 ATOM 2571 C CG . TRP A 1 324 ? -7.918 -13.885 12.525 1.00 30.20 ? 324 TRP A CG 1 ATOM 2572 C CD1 . TRP A 1 324 ? -6.820 -13.079 12.584 1.00 28.91 ? 324 TRP A CD1 1 ATOM 2573 C CD2 . TRP A 1 324 ? -7.675 -14.973 13.397 1.00 28.70 ? 324 TRP A CD2 1 ATOM 2574 N NE1 . TRP A 1 324 ? -5.897 -13.603 13.469 1.00 28.86 ? 324 TRP A NE1 1 ATOM 2575 C CE2 . TRP A 1 324 ? -6.399 -14.766 13.978 1.00 28.03 ? 324 TRP A CE2 1 ATOM 2576 C CE3 . TRP A 1 324 ? -8.405 -16.109 13.745 1.00 27.85 ? 324 TRP A CE3 1 ATOM 2577 C CZ2 . TRP A 1 324 ? -5.846 -15.651 14.879 1.00 30.88 ? 324 TRP A CZ2 1 ATOM 2578 C CZ3 . TRP A 1 324 ? -7.870 -16.972 14.659 1.00 29.19 ? 324 TRP A CZ3 1 ATOM 2579 C CH2 . TRP A 1 324 ? -6.599 -16.748 15.220 1.00 29.74 ? 324 TRP A CH2 1 ATOM 2580 N N . ILE A 1 325 ? -10.578 -13.816 8.899 1.00 32.51 ? 325 ILE A N 1 ATOM 2581 C CA . ILE A 1 325 ? -11.783 -13.671 8.117 1.00 32.11 ? 325 ILE A CA 1 ATOM 2582 C C . ILE A 1 325 ? -11.444 -13.765 6.619 1.00 32.17 ? 325 ILE A C 1 ATOM 2583 O O . ILE A 1 325 ? -11.264 -12.736 5.952 1.00 32.15 ? 325 ILE A O 1 ATOM 2584 C CB . ILE A 1 325 ? -12.459 -12.325 8.380 1.00 31.57 ? 325 ILE A CB 1 ATOM 2585 C CG1 . ILE A 1 325 ? -12.232 -11.871 9.823 1.00 30.88 ? 325 ILE A CG1 1 ATOM 2586 C CG2 . ILE A 1 325 ? -13.918 -12.412 7.989 1.00 32.84 ? 325 ILE A CG2 1 ATOM 2587 C CD1 . ILE A 1 325 ? -13.025 -10.659 10.245 1.00 28.65 ? 325 ILE A CD1 1 ATOM 2588 N N . PRO A 1 326 ? -11.349 -14.998 6.094 1.00 32.20 ? 326 PRO A N 1 ATOM 2589 C CA . PRO A 1 326 ? -11.139 -15.242 4.670 1.00 32.90 ? 326 PRO A CA 1 ATOM 2590 C C . PRO A 1 326 ? -12.391 -14.918 3.867 1.00 33.89 ? 326 PRO A C 1 ATOM 2591 O O . PRO A 1 326 ? -13.439 -14.661 4.450 1.00 34.17 ? 326 PRO A O 1 ATOM 2592 C CB . PRO A 1 326 ? -10.828 -16.747 4.610 1.00 32.99 ? 326 PRO A CB 1 ATOM 2593 C CG . PRO A 1 326 ? -11.398 -17.329 5.853 1.00 31.77 ? 326 PRO A CG 1 ATOM 2594 C CD . PRO A 1 326 ? -11.381 -16.248 6.882 1.00 32.25 ? 326 PRO A CD 1 ATOM 2595 N N . PRO A 1 327 ? -12.307 -14.942 2.525 1.00 35.16 ? 327 PRO A N 1 ATOM 2596 C CA . PRO A 1 327 ? -13.543 -14.592 1.798 1.00 35.27 ? 327 PRO A CA 1 ATOM 2597 C C . PRO A 1 327 ? -14.696 -15.503 2.164 1.00 35.53 ? 327 PRO A C 1 ATOM 2598 O O . PRO A 1 327 ? -14.481 -16.645 2.598 1.00 35.18 ? 327 PRO A O 1 ATOM 2599 C CB . PRO A 1 327 ? -13.144 -14.741 0.319 1.00 35.24 ? 327 PRO A CB 1 ATOM 2600 C CG . PRO A 1 327 ? -11.649 -14.362 0.327 1.00 35.40 ? 327 PRO A CG 1 ATOM 2601 C CD . PRO A 1 327 ? -11.138 -15.025 1.616 1.00 35.46 ? 327 PRO A CD 1 ATOM 2602 N N . TYR A 1 328 ? -15.903 -14.964 2.019 1.00 35.37 ? 328 TYR A N 1 ATOM 2603 C CA . TYR A 1 328 ? -17.117 -15.640 2.394 1.00 35.36 ? 328 TYR A CA 1 ATOM 2604 C C . TYR A 1 328 ? -17.422 -16.773 1.428 1.00 36.50 ? 328 TYR A C 1 ATOM 2605 O O . TYR A 1 328 ? -17.190 -16.668 0.224 1.00 37.15 ? 328 TYR A O 1 ATOM 2606 C CB . TYR A 1 328 ? -18.245 -14.634 2.397 1.00 34.96 ? 328 TYR A CB 1 ATOM 2607 C CG . TYR A 1 328 ? -19.570 -15.076 2.982 1.00 33.44 ? 328 TYR A CG 1 ATOM 2608 C CD1 . TYR A 1 328 ? -19.684 -15.504 4.299 1.00 31.21 ? 328 TYR A CD1 1 ATOM 2609 C CD2 . TYR A 1 328 ? -20.713 -14.998 2.224 1.00 28.92 ? 328 TYR A CD2 1 ATOM 2610 C CE1 . TYR A 1 328 ? -20.928 -15.859 4.822 1.00 29.10 ? 328 TYR A CE1 1 ATOM 2611 C CE2 . TYR A 1 328 ? -21.904 -15.346 2.707 1.00 26.45 ? 328 TYR A CE2 1 ATOM 2612 C CZ . TYR A 1 328 ? -22.040 -15.768 4.001 1.00 28.50 ? 328 TYR A CZ 1 ATOM 2613 O OH . TYR A 1 328 ? -23.311 -16.087 4.446 1.00 26.13 ? 328 TYR A OH 1 ATOM 2614 N N . GLN A 1 329 ? -17.954 -17.850 1.998 1.00 37.15 ? 329 GLN A N 1 ATOM 2615 C CA . GLN A 1 329 ? -18.203 -19.123 1.355 1.00 36.83 ? 329 GLN A CA 1 ATOM 2616 C C . GLN A 1 329 ? -19.647 -19.498 1.657 1.00 36.58 ? 329 GLN A C 1 ATOM 2617 O O . GLN A 1 329 ? -20.178 -20.446 1.106 1.00 37.46 ? 329 GLN A O 1 ATOM 2618 C CB . GLN A 1 329 ? -17.306 -20.173 1.987 1.00 37.13 ? 329 GLN A CB 1 ATOM 2619 C CG . GLN A 1 329 ? -15.882 -19.735 2.187 1.00 37.94 ? 329 GLN A CG 1 ATOM 2620 C CD . GLN A 1 329 ? -14.981 -20.089 1.025 1.00 41.59 ? 329 GLN A CD 1 ATOM 2621 O OE1 . GLN A 1 329 ? -15.020 -19.453 -0.039 1.00 43.01 ? 329 GLN A OE1 1 ATOM 2622 N NE2 . GLN A 1 329 ? -14.141 -21.103 1.226 1.00 43.99 ? 329 GLN A NE2 1 ATOM 2623 N N . GLY A 1 330 ? -20.285 -18.753 2.547 1.00 35.71 ? 330 GLY A N 1 ATOM 2624 C CA . GLY A 1 330 ? -21.705 -18.934 2.781 1.00 35.12 ? 330 GLY A CA 1 ATOM 2625 C C . GLY A 1 330 ? -22.018 -19.316 4.205 1.00 34.63 ? 330 GLY A C 1 ATOM 2626 O O . GLY A 1 330 ? -21.111 -19.683 4.980 1.00 34.75 ? 330 GLY A O 1 ATOM 2627 N N . TYR A 1 331 ? -23.301 -19.215 4.536 1.00 33.82 ? 331 TYR A N 1 ATOM 2628 C CA . TYR A 1 331 ? -23.821 -19.525 5.863 1.00 34.05 ? 331 TYR A CA 1 ATOM 2629 C C . TYR A 1 331 ? -23.422 -20.934 6.301 1.00 34.25 ? 331 TYR A C 1 ATOM 2630 O O . TYR A 1 331 ? -23.755 -21.921 5.651 1.00 35.44 ? 331 TYR A O 1 ATOM 2631 C CB . TYR A 1 331 ? -25.356 -19.322 5.879 1.00 33.94 ? 331 TYR A CB 1 ATOM 2632 C CG . TYR A 1 331 ? -26.108 -19.763 7.137 1.00 34.42 ? 331 TYR A CG 1 ATOM 2633 C CD1 . TYR A 1 331 ? -25.742 -19.298 8.409 1.00 32.82 ? 331 TYR A CD1 1 ATOM 2634 C CD2 . TYR A 1 331 ? -27.219 -20.606 7.048 1.00 34.41 ? 331 TYR A CD2 1 ATOM 2635 C CE1 . TYR A 1 331 ? -26.438 -19.674 9.545 1.00 31.80 ? 331 TYR A CE1 1 ATOM 2636 C CE2 . TYR A 1 331 ? -27.930 -20.983 8.197 1.00 33.44 ? 331 TYR A CE2 1 ATOM 2637 C CZ . TYR A 1 331 ? -27.530 -20.513 9.438 1.00 32.44 ? 331 TYR A CZ 1 ATOM 2638 O OH . TYR A 1 331 ? -28.205 -20.903 10.574 1.00 31.74 ? 331 TYR A OH 1 ATOM 2639 N N . ASN A 1 332 ? -22.714 -21.004 7.425 1.00 33.98 ? 332 ASN A N 1 ATOM 2640 C CA . ASN A 1 332 ? -22.334 -22.272 8.035 1.00 33.18 ? 332 ASN A CA 1 ATOM 2641 C C . ASN A 1 332 ? -23.055 -22.462 9.366 1.00 33.28 ? 332 ASN A C 1 ATOM 2642 O O . ASN A 1 332 ? -22.568 -22.042 10.416 1.00 33.77 ? 332 ASN A O 1 ATOM 2643 C CB . ASN A 1 332 ? -20.820 -22.339 8.240 1.00 33.35 ? 332 ASN A CB 1 ATOM 2644 C CG . ASN A 1 332 ? -20.215 -23.622 7.705 1.00 33.98 ? 332 ASN A CG 1 ATOM 2645 O OD1 . ASN A 1 332 ? -20.812 -24.694 7.810 1.00 30.39 ? 332 ASN A OD1 1 ATOM 2646 N ND2 . ASN A 1 332 ? -19.024 -23.519 7.127 1.00 38.52 ? 332 ASN A ND2 1 ATOM 2647 N N . ASN A 1 333 ? -24.224 -23.091 9.308 1.00 32.64 ? 333 ASN A N 1 ATOM 2648 C CA . ASN A 1 333 ? -25.078 -23.257 10.465 1.00 31.33 ? 333 ASN A CA 1 ATOM 2649 C C . ASN A 1 333 ? -24.465 -24.008 11.671 1.00 30.10 ? 333 ASN A C 1 ATOM 2650 O O . ASN A 1 333 ? -25.060 -24.065 12.763 1.00 28.57 ? 333 ASN A O 1 ATOM 2651 C CB . ASN A 1 333 ? -26.485 -23.737 10.024 1.00 31.56 ? 333 ASN A CB 1 ATOM 2652 C CG . ASN A 1 333 ? -26.673 -25.261 10.044 1.00 33.55 ? 333 ASN A CG 1 ATOM 2653 O OD1 . ASN A 1 333 ? -25.773 -26.048 9.725 1.00 34.52 ? 333 ASN A OD1 1 ATOM 2654 N ND2 . ASN A 1 333 ? -27.894 -25.677 10.393 1.00 34.39 ? 333 ASN A ND2 1 ATOM 2655 N N . SER A 1 334 ? -23.263 -24.547 11.479 1.00 29.35 ? 334 SER A N 1 ATOM 2656 C CA . SER A 1 334 ? -22.514 -25.148 12.588 1.00 29.14 ? 334 SER A CA 1 ATOM 2657 C C . SER A 1 334 ? -21.679 -24.135 13.373 1.00 29.37 ? 334 SER A C 1 ATOM 2658 O O . SER A 1 334 ? -21.112 -24.494 14.414 1.00 29.83 ? 334 SER A O 1 ATOM 2659 C CB . SER A 1 334 ? -21.586 -26.237 12.086 1.00 29.06 ? 334 SER A CB 1 ATOM 2660 O OG . SER A 1 334 ? -22.304 -27.345 11.561 1.00 31.06 ? 334 SER A OG 1 ATOM 2661 N N . VAL A 1 335 ? -21.565 -22.899 12.860 1.00 28.30 ? 335 VAL A N 1 ATOM 2662 C CA . VAL A 1 335 ? -20.783 -21.845 13.507 1.00 27.27 ? 335 VAL A CA 1 ATOM 2663 C C . VAL A 1 335 ? -21.584 -21.199 14.628 1.00 26.65 ? 335 VAL A C 1 ATOM 2664 O O . VAL A 1 335 ? -22.790 -21.034 14.499 1.00 26.20 ? 335 VAL A O 1 ATOM 2665 C CB . VAL A 1 335 ? -20.342 -20.766 12.483 1.00 27.25 ? 335 VAL A CB 1 ATOM 2666 C CG1 . VAL A 1 335 ? -19.940 -19.463 13.183 1.00 25.96 ? 335 VAL A CG1 1 ATOM 2667 C CG2 . VAL A 1 335 ? -19.194 -21.287 11.635 1.00 26.04 ? 335 VAL A CG2 1 ATOM 2668 N N . ASP A 1 336 ? -20.897 -20.825 15.708 1.00 26.20 ? 336 ASP A N 1 ATOM 2669 C CA . ASP A 1 336 ? -21.508 -20.188 16.895 1.00 25.82 ? 336 ASP A CA 1 ATOM 2670 C C . ASP A 1 336 ? -21.495 -18.642 16.783 1.00 25.64 ? 336 ASP A C 1 ATOM 2671 O O . ASP A 1 336 ? -20.426 -18.002 16.859 1.00 24.70 ? 336 ASP A O 1 ATOM 2672 C CB . ASP A 1 336 ? -20.775 -20.670 18.169 1.00 26.23 ? 336 ASP A CB 1 ATOM 2673 C CG . ASP A 1 336 ? -21.351 -20.085 19.469 1.00 26.92 ? 336 ASP A CG 1 ATOM 2674 O OD1 . ASP A 1 336 ? -22.467 -19.535 19.489 1.00 28.79 ? 336 ASP A OD1 1 ATOM 2675 O OD2 . ASP A 1 336 ? -20.678 -20.199 20.500 1.00 28.09 ? 336 ASP A OD2 1 ATOM 2676 N N . PRO A 1 337 ? -22.687 -18.041 16.608 1.00 25.69 ? 337 PRO A N 1 ATOM 2677 C CA . PRO A 1 337 ? -22.836 -16.607 16.345 1.00 25.82 ? 337 PRO A CA 1 ATOM 2678 C C . PRO A 1 337 ? -22.788 -15.723 17.589 1.00 25.61 ? 337 PRO A C 1 ATOM 2679 O O . PRO A 1 337 ? -22.770 -14.493 17.460 1.00 26.72 ? 337 PRO A O 1 ATOM 2680 C CB . PRO A 1 337 ? -24.245 -16.499 15.729 1.00 26.01 ? 337 PRO A CB 1 ATOM 2681 C CG . PRO A 1 337 ? -24.893 -17.865 15.885 1.00 25.18 ? 337 PRO A CG 1 ATOM 2682 C CD . PRO A 1 337 ? -24.000 -18.710 16.716 1.00 26.26 ? 337 PRO A CD 1 ATOM 2683 N N . ARG A 1 338 ? -22.774 -16.324 18.771 1.00 24.78 ? 338 ARG A N 1 ATOM 2684 C CA . ARG A 1 338 ? -22.880 -15.561 20.011 1.00 24.17 ? 338 ARG A CA 1 ATOM 2685 C C . ARG A 1 338 ? -21.582 -14.815 20.237 1.00 23.90 ? 338 ARG A C 1 ATOM 2686 O O . ARG A 1 338 ? -20.502 -15.301 19.858 1.00 22.80 ? 338 ARG A O 1 ATOM 2687 C CB . ARG A 1 338 ? -23.124 -16.467 21.205 1.00 24.17 ? 338 ARG A CB 1 ATOM 2688 C CG . ARG A 1 338 ? -24.421 -17.284 21.195 1.00 25.04 ? 338 ARG A CG 1 ATOM 2689 C CD . ARG A 1 338 ? -24.406 -18.247 22.368 1.00 26.96 ? 338 ARG A CD 1 ATOM 2690 N NE . ARG A 1 338 ? -23.470 -19.332 22.113 1.00 27.89 ? 338 ARG A NE 1 ATOM 2691 C CZ . ARG A 1 338 ? -22.845 -20.058 23.033 1.00 27.81 ? 338 ARG A CZ 1 ATOM 2692 N NH1 . ARG A 1 338 ? -23.020 -19.842 24.339 1.00 27.35 ? 338 ARG A NH1 1 ATOM 2693 N NH2 . ARG A 1 338 ? -22.022 -21.010 22.624 1.00 27.63 ? 338 ARG A NH2 1 ATOM 2694 N N . ILE A 1 339 ? -21.729 -13.616 20.816 1.00 22.56 ? 339 ILE A N 1 ATOM 2695 C CA . ILE A 1 339 ? -20.632 -12.789 21.273 1.00 20.91 ? 339 ILE A CA 1 ATOM 2696 C C . ILE A 1 339 ? -20.013 -13.450 22.506 1.00 21.12 ? 339 ILE A C 1 ATOM 2697 O O . ILE A 1 339 ? -20.720 -13.901 23.439 1.00 21.80 ? 339 ILE A O 1 ATOM 2698 C CB . ILE A 1 339 ? -21.099 -11.326 21.627 1.00 20.48 ? 339 ILE A CB 1 ATOM 2699 C CG1 . ILE A 1 339 ? -21.759 -10.628 20.428 1.00 19.91 ? 339 ILE A CG1 1 ATOM 2700 C CG2 . ILE A 1 339 ? -19.949 -10.485 22.146 1.00 17.20 ? 339 ILE A CG2 1 ATOM 2701 C CD1 . ILE A 1 339 ? -20.834 -10.496 19.153 1.00 19.86 ? 339 ILE A CD1 1 ATOM 2702 N N . SER A 1 340 ? -18.690 -13.522 22.513 1.00 20.03 ? 340 SER A N 1 ATOM 2703 C CA . SER A 1 340 ? -18.008 -14.138 23.629 1.00 19.53 ? 340 SER A CA 1 ATOM 2704 C C . SER A 1 340 ? -17.947 -13.068 24.677 1.00 19.53 ? 340 SER A C 1 ATOM 2705 O O . SER A 1 340 ? -17.948 -11.860 24.377 1.00 19.39 ? 340 SER A O 1 ATOM 2706 C CB . SER A 1 340 ? -16.594 -14.595 23.244 1.00 19.75 ? 340 SER A CB 1 ATOM 2707 O OG . SER A 1 340 ? -15.999 -13.703 22.307 1.00 17.68 ? 340 SER A OG 1 ATOM 2708 N N . ASN A 1 341 ? -17.904 -13.509 25.924 1.00 19.29 ? 341 ASN A N 1 ATOM 2709 C CA . ASN A 1 341 ? -17.662 -12.582 27.007 1.00 18.33 ? 341 ASN A CA 1 ATOM 2710 C C . ASN A 1 341 ? -16.389 -11.769 26.747 1.00 18.06 ? 341 ASN A C 1 ATOM 2711 O O . ASN A 1 341 ? -16.431 -10.519 26.824 1.00 18.11 ? 341 ASN A O 1 ATOM 2712 C CB . ASN A 1 341 ? -17.596 -13.336 28.320 1.00 18.39 ? 341 ASN A CB 1 ATOM 2713 C CG . ASN A 1 341 ? -18.090 -12.523 29.442 1.00 19.62 ? 341 ASN A CG 1 ATOM 2714 O OD1 . ASN A 1 341 ? -17.773 -11.347 29.534 1.00 24.38 ? 341 ASN A OD1 1 ATOM 2715 N ND2 . ASN A 1 341 ? -18.902 -13.116 30.303 1.00 19.25 ? 341 ASN A ND2 1 ATOM 2716 N N . VAL A 1 342 ? -15.289 -12.464 26.405 1.00 16.79 ? 342 VAL A N 1 ATOM 2717 C CA . VAL A 1 342 ? -14.010 -11.816 26.119 1.00 16.08 ? 342 VAL A CA 1 ATOM 2718 C C . VAL A 1 342 ? -14.084 -10.716 25.045 1.00 15.79 ? 342 VAL A C 1 ATOM 2719 O O . VAL A 1 342 ? -13.611 -9.636 25.277 1.00 16.42 ? 342 VAL A O 1 ATOM 2720 C CB . VAL A 1 342 ? -12.847 -12.833 25.792 1.00 16.75 ? 342 VAL A CB 1 ATOM 2721 C CG1 . VAL A 1 342 ? -13.128 -13.628 24.550 1.00 15.43 ? 342 VAL A CG1 1 ATOM 2722 C CG2 . VAL A 1 342 ? -11.497 -12.100 25.645 1.00 14.45 ? 342 VAL A CG2 1 ATOM 2723 N N . PHE A 1 343 ? -14.699 -10.967 23.900 1.00 15.43 ? 343 PHE A N 1 ATOM 2724 C CA . PHE A 1 343 ? -14.935 -9.904 22.911 1.00 15.51 ? 343 PHE A CA 1 ATOM 2725 C C . PHE A 1 343 ? -15.412 -8.564 23.507 1.00 15.89 ? 343 PHE A C 1 ATOM 2726 O O . PHE A 1 343 ? -14.996 -7.505 23.039 1.00 15.98 ? 343 PHE A O 1 ATOM 2727 C CB . PHE A 1 343 ? -15.969 -10.375 21.879 1.00 15.09 ? 343 PHE A CB 1 ATOM 2728 C CG . PHE A 1 343 ? -16.177 -9.416 20.699 1.00 14.39 ? 343 PHE A CG 1 ATOM 2729 C CD1 . PHE A 1 343 ? -15.277 -9.397 19.636 1.00 13.69 ? 343 PHE A CD1 1 ATOM 2730 C CD2 . PHE A 1 343 ? -17.324 -8.597 20.628 1.00 13.54 ? 343 PHE A CD2 1 ATOM 2731 C CE1 . PHE A 1 343 ? -15.491 -8.550 18.515 1.00 12.89 ? 343 PHE A CE1 1 ATOM 2732 C CE2 . PHE A 1 343 ? -17.577 -7.759 19.541 1.00 11.35 ? 343 PHE A CE2 1 ATOM 2733 C CZ . PHE A 1 343 ? -16.646 -7.753 18.448 1.00 16.70 ? 343 PHE A CZ 1 ATOM 2734 N N . THR A 1 344 ? -16.317 -8.599 24.494 1.00 15.12 ? 344 THR A N 1 ATOM 2735 C CA . THR A 1 344 ? -16.880 -7.353 25.031 1.00 14.27 ? 344 THR A CA 1 ATOM 2736 C C . THR A 1 344 ? -15.762 -6.590 25.704 1.00 15.20 ? 344 THR A C 1 ATOM 2737 O O . THR A 1 344 ? -15.909 -5.405 26.012 1.00 16.70 ? 344 THR A O 1 ATOM 2738 C CB . THR A 1 344 ? -18.054 -7.556 26.088 1.00 14.44 ? 344 THR A CB 1 ATOM 2739 O OG1 . THR A 1 344 ? -17.526 -7.997 27.355 1.00 12.05 ? 344 THR A OG1 1 ATOM 2740 C CG2 . THR A 1 344 ? -19.136 -8.514 25.610 1.00 9.73 ? 344 THR A CG2 1 ATOM 2741 N N . PHE A 1 345 ? -14.660 -7.271 25.978 1.00 14.54 ? 345 PHE A N 1 ATOM 2742 C CA . PHE A 1 345 ? -13.484 -6.576 26.467 1.00 15.91 ? 345 PHE A CA 1 ATOM 2743 C C . PHE A 1 345 ? -12.470 -6.259 25.372 1.00 16.05 ? 345 PHE A C 1 ATOM 2744 O O . PHE A 1 345 ? -11.955 -5.144 25.347 1.00 18.40 ? 345 PHE A O 1 ATOM 2745 C CB . PHE A 1 345 ? -12.888 -7.312 27.663 1.00 16.49 ? 345 PHE A CB 1 ATOM 2746 C CG . PHE A 1 345 ? -13.866 -7.425 28.779 1.00 18.19 ? 345 PHE A CG 1 ATOM 2747 C CD1 . PHE A 1 345 ? -14.554 -8.608 29.014 1.00 18.23 ? 345 PHE A CD1 1 ATOM 2748 C CD2 . PHE A 1 345 ? -14.238 -6.287 29.489 1.00 21.07 ? 345 PHE A CD2 1 ATOM 2749 C CE1 . PHE A 1 345 ? -15.532 -8.674 29.997 1.00 19.43 ? 345 PHE A CE1 1 ATOM 2750 C CE2 . PHE A 1 345 ? -15.223 -6.363 30.473 1.00 21.11 ? 345 PHE A CE2 1 ATOM 2751 C CZ . PHE A 1 345 ? -15.837 -7.576 30.739 1.00 18.75 ? 345 PHE A CZ 1 ATOM 2752 N N . ALA A 1 346 ? -12.227 -7.183 24.458 1.00 15.06 ? 346 ALA A N 1 ATOM 2753 C CA . ALA A 1 346 ? -11.352 -6.938 23.317 1.00 17.01 ? 346 ALA A CA 1 ATOM 2754 C C . ALA A 1 346 ? -11.750 -5.735 22.439 1.00 17.22 ? 346 ALA A C 1 ATOM 2755 O O . ALA A 1 346 ? -10.886 -5.039 21.964 1.00 19.04 ? 346 ALA A O 1 ATOM 2756 C CB . ALA A 1 346 ? -11.203 -8.235 22.430 1.00 16.30 ? 346 ALA A CB 1 ATOM 2757 N N . PHE A 1 347 ? -13.041 -5.514 22.204 1.00 17.45 ? 347 PHE A N 1 ATOM 2758 C CA . PHE A 1 347 ? -13.507 -4.420 21.376 1.00 16.82 ? 347 PHE A CA 1 ATOM 2759 C C . PHE A 1 347 ? -13.390 -3.071 22.122 1.00 17.74 ? 347 PHE A C 1 ATOM 2760 O O . PHE A 1 347 ? -13.523 -1.986 21.530 1.00 17.81 ? 347 PHE A O 1 ATOM 2761 C CB . PHE A 1 347 ? -14.949 -4.689 20.930 1.00 17.18 ? 347 PHE A CB 1 ATOM 2762 C CG . PHE A 1 347 ? -15.309 -4.099 19.589 1.00 16.88 ? 347 PHE A CG 1 ATOM 2763 C CD1 . PHE A 1 347 ? -14.423 -3.253 18.901 1.00 19.98 ? 347 PHE A CD1 1 ATOM 2764 C CD2 . PHE A 1 347 ? -16.518 -4.383 19.011 1.00 17.97 ? 347 PHE A CD2 1 ATOM 2765 C CE1 . PHE A 1 347 ? -14.736 -2.748 17.641 1.00 17.23 ? 347 PHE A CE1 1 ATOM 2766 C CE2 . PHE A 1 347 ? -16.853 -3.859 17.764 1.00 18.95 ? 347 PHE A CE2 1 ATOM 2767 C CZ . PHE A 1 347 ? -15.960 -3.021 17.088 1.00 16.17 ? 347 PHE A CZ 1 ATOM 2768 N N . ARG A 1 348 ? -13.117 -3.129 23.421 1.00 17.66 ? 348 ARG A N 1 ATOM 2769 C CA . ARG A 1 348 ? -12.781 -1.909 24.177 1.00 17.08 ? 348 ARG A CA 1 ATOM 2770 C C . ARG A 1 348 ? -11.450 -1.276 23.817 1.00 16.72 ? 348 ARG A C 1 ATOM 2771 O O . ARG A 1 348 ? -11.054 -0.302 24.459 1.00 16.39 ? 348 ARG A O 1 ATOM 2772 C CB . ARG A 1 348 ? -12.846 -2.159 25.669 1.00 17.23 ? 348 ARG A CB 1 ATOM 2773 C CG . ARG A 1 348 ? -14.304 -2.134 26.185 1.00 19.15 ? 348 ARG A CG 1 ATOM 2774 C CD . ARG A 1 348 ? -14.297 -2.765 27.531 1.00 20.33 ? 348 ARG A CD 1 ATOM 2775 N NE . ARG A 1 348 ? -15.502 -3.509 27.799 1.00 22.84 ? 348 ARG A NE 1 ATOM 2776 C CZ . ARG A 1 348 ? -16.314 -3.270 28.826 1.00 22.65 ? 348 ARG A CZ 1 ATOM 2777 N NH1 . ARG A 1 348 ? -16.065 -2.287 29.692 1.00 23.00 ? 348 ARG A NH1 1 ATOM 2778 N NH2 . ARG A 1 348 ? -17.379 -4.023 28.993 1.00 23.04 ? 348 ARG A NH2 1 ATOM 2779 N N . PHE A 1 349 ? -10.781 -1.783 22.776 1.00 15.88 ? 349 PHE A N 1 ATOM 2780 C CA . PHE A 1 349 ? -9.559 -1.118 22.320 1.00 16.35 ? 349 PHE A CA 1 ATOM 2781 C C . PHE A 1 349 ? -9.961 0.254 21.882 1.00 16.76 ? 349 PHE A C 1 ATOM 2782 O O . PHE A 1 349 ? -9.238 1.221 22.046 1.00 16.71 ? 349 PHE A O 1 ATOM 2783 C CB . PHE A 1 349 ? -8.845 -1.873 21.153 1.00 16.10 ? 349 PHE A CB 1 ATOM 2784 C CG . PHE A 1 349 ? -9.566 -1.766 19.812 1.00 15.98 ? 349 PHE A CG 1 ATOM 2785 C CD1 . PHE A 1 349 ? -9.417 -0.656 19.009 1.00 13.29 ? 349 PHE A CD1 1 ATOM 2786 C CD2 . PHE A 1 349 ? -10.398 -2.795 19.372 1.00 15.94 ? 349 PHE A CD2 1 ATOM 2787 C CE1 . PHE A 1 349 ? -10.112 -0.558 17.807 1.00 14.16 ? 349 PHE A CE1 1 ATOM 2788 C CE2 . PHE A 1 349 ? -11.053 -2.712 18.170 1.00 14.07 ? 349 PHE A CE2 1 ATOM 2789 C CZ . PHE A 1 349 ? -10.915 -1.599 17.392 1.00 14.28 ? 349 PHE A CZ 1 ATOM 2790 N N . GLY A 1 350 ? -11.153 0.319 21.310 1.00 18.06 ? 350 GLY A N 1 ATOM 2791 C CA . GLY A 1 350 ? -11.702 1.553 20.832 1.00 19.53 ? 350 GLY A CA 1 ATOM 2792 C C . GLY A 1 350 ? -11.536 2.651 21.851 1.00 20.61 ? 350 GLY A C 1 ATOM 2793 O O . GLY A 1 350 ? -11.424 3.838 21.508 1.00 21.18 ? 350 GLY A O 1 ATOM 2794 N N . HIS A 1 351 ? -11.499 2.268 23.113 1.00 22.02 ? 351 HIS A N 1 ATOM 2795 C CA . HIS A 1 351 ? -11.280 3.278 24.136 1.00 22.80 ? 351 HIS A CA 1 ATOM 2796 C C . HIS A 1 351 ? -10.017 4.106 23.987 1.00 23.03 ? 351 HIS A C 1 ATOM 2797 O O . HIS A 1 351 ? -10.002 5.273 24.379 1.00 22.87 ? 351 HIS A O 1 ATOM 2798 C CB . HIS A 1 351 ? -11.447 2.680 25.522 1.00 22.41 ? 351 HIS A CB 1 ATOM 2799 C CG . HIS A 1 351 ? -12.849 2.226 25.776 1.00 21.31 ? 351 HIS A CG 1 ATOM 2800 N ND1 . HIS A 1 351 ? -13.206 1.452 26.856 1.00 18.18 ? 351 HIS A ND1 1 ATOM 2801 C CD2 . HIS A 1 351 ? -13.973 2.397 25.041 1.00 19.13 ? 351 HIS A CD2 1 ATOM 2802 C CE1 . HIS A 1 351 ? -14.499 1.200 26.795 1.00 21.24 ? 351 HIS A CE1 1 ATOM 2803 N NE2 . HIS A 1 351 ? -14.987 1.762 25.701 1.00 23.16 ? 351 HIS A NE2 1 ATOM 2804 N N . MET A 1 352 ? -8.983 3.527 23.386 1.00 23.78 ? 352 MET A N 1 ATOM 2805 C CA . MET A 1 352 ? -7.722 4.261 23.205 1.00 25.38 ? 352 MET A CA 1 ATOM 2806 C C . MET A 1 352 ? -7.666 5.057 21.896 1.00 25.11 ? 352 MET A C 1 ATOM 2807 O O . MET A 1 352 ? -6.665 5.698 21.583 1.00 25.81 ? 352 MET A O 1 ATOM 2808 C CB . MET A 1 352 ? -6.545 3.309 23.334 1.00 25.51 ? 352 MET A CB 1 ATOM 2809 C CG . MET A 1 352 ? -6.836 2.306 24.435 1.00 30.14 ? 352 MET A CG 1 ATOM 2810 S SD . MET A 1 352 ? -5.341 1.698 25.109 1.00 40.14 ? 352 MET A SD 1 ATOM 2811 C CE . MET A 1 352 ? -5.968 0.768 26.518 1.00 36.56 ? 352 MET A CE 1 ATOM 2812 N N . GLU A 1 353 ? -8.756 5.026 21.146 1.00 24.15 ? 353 GLU A N 1 ATOM 2813 C CA . GLU A 1 353 ? -8.798 5.708 19.888 1.00 23.79 ? 353 GLU A CA 1 ATOM 2814 C C . GLU A 1 353 ? -9.587 6.988 19.978 1.00 23.64 ? 353 GLU A C 1 ATOM 2815 O O . GLU A 1 353 ? -9.854 7.628 18.971 1.00 23.58 ? 353 GLU A O 1 ATOM 2816 C CB . GLU A 1 353 ? -9.351 4.766 18.830 1.00 24.06 ? 353 GLU A CB 1 ATOM 2817 C CG . GLU A 1 353 ? -8.529 3.506 18.748 1.00 21.87 ? 353 GLU A CG 1 ATOM 2818 C CD . GLU A 1 353 ? -9.034 2.590 17.700 1.00 24.69 ? 353 GLU A CD 1 ATOM 2819 O OE1 . GLU A 1 353 ? -10.178 2.792 17.259 1.00 23.87 ? 353 GLU A OE1 1 ATOM 2820 O OE2 . GLU A 1 353 ? -8.283 1.656 17.303 1.00 28.10 ? 353 GLU A OE2 1 ATOM 2821 N N . VAL A 1 354 ? -9.930 7.367 21.204 1.00 23.45 ? 354 VAL A N 1 ATOM 2822 C CA . VAL A 1 354 ? -10.796 8.499 21.472 1.00 22.97 ? 354 VAL A CA 1 ATOM 2823 C C . VAL A 1 354 ? -9.933 9.685 21.881 1.00 23.63 ? 354 VAL A C 1 ATOM 2824 O O . VAL A 1 354 ? -9.187 9.589 22.846 1.00 22.64 ? 354 VAL A O 1 ATOM 2825 C CB . VAL A 1 354 ? -11.780 8.166 22.610 1.00 22.60 ? 354 VAL A CB 1 ATOM 2826 C CG1 . VAL A 1 354 ? -12.582 9.363 22.959 1.00 22.96 ? 354 VAL A CG1 1 ATOM 2827 C CG2 . VAL A 1 354 ? -12.710 7.019 22.206 1.00 21.71 ? 354 VAL A CG2 1 ATOM 2828 N N . PRO A 1 355 ? -10.039 10.812 21.141 1.00 24.66 ? 355 PRO A N 1 ATOM 2829 C CA . PRO A 1 355 ? -9.195 11.980 21.352 1.00 24.68 ? 355 PRO A CA 1 ATOM 2830 C C . PRO A 1 355 ? -9.845 12.886 22.398 1.00 24.90 ? 355 PRO A C 1 ATOM 2831 O O . PRO A 1 355 ? -11.014 12.674 22.754 1.00 23.26 ? 355 PRO A O 1 ATOM 2832 C CB . PRO A 1 355 ? -9.235 12.659 19.980 1.00 24.86 ? 355 PRO A CB 1 ATOM 2833 C CG . PRO A 1 355 ? -10.652 12.421 19.532 1.00 25.66 ? 355 PRO A CG 1 ATOM 2834 C CD . PRO A 1 355 ? -11.104 11.109 20.162 1.00 24.65 ? 355 PRO A CD 1 ATOM 2835 N N . SER A 1 356 ? -9.087 13.879 22.866 1.00 25.43 ? 356 SER A N 1 ATOM 2836 C CA . SER A 1 356 ? -9.545 14.788 23.922 1.00 26.75 ? 356 SER A CA 1 ATOM 2837 C C . SER A 1 356 ? -10.605 15.833 23.544 1.00 26.80 ? 356 SER A C 1 ATOM 2838 O O . SER A 1 356 ? -11.265 16.379 24.427 1.00 27.55 ? 356 SER A O 1 ATOM 2839 C CB . SER A 1 356 ? -8.368 15.471 24.596 1.00 26.29 ? 356 SER A CB 1 ATOM 2840 O OG . SER A 1 356 ? -7.898 16.471 23.745 1.00 28.03 ? 356 SER A OG 1 ATOM 2841 N N . THR A 1 357 ? -10.798 16.093 22.255 1.00 27.66 ? 357 THR A N 1 ATOM 2842 C CA . THR A 1 357 ? -11.762 17.118 21.809 1.00 27.83 ? 357 THR A CA 1 ATOM 2843 C C . THR A 1 357 ? -12.599 16.680 20.604 1.00 27.97 ? 357 THR A C 1 ATOM 2844 O O . THR A 1 357 ? -12.222 15.776 19.873 1.00 27.42 ? 357 THR A O 1 ATOM 2845 C CB . THR A 1 357 ? -11.090 18.472 21.416 1.00 27.89 ? 357 THR A CB 1 ATOM 2846 O OG1 . THR A 1 357 ? -10.232 18.293 20.282 1.00 27.93 ? 357 THR A OG1 1 ATOM 2847 C CG2 . THR A 1 357 ? -10.302 19.084 22.547 1.00 27.92 ? 357 THR A CG2 1 ATOM 2848 N N . VAL A 1 358 ? -13.734 17.353 20.424 1.00 28.29 ? 358 VAL A N 1 ATOM 2849 C CA . VAL A 1 358 ? -14.629 17.153 19.305 1.00 28.85 ? 358 VAL A CA 1 ATOM 2850 C C . VAL A 1 358 ? -14.942 18.524 18.753 1.00 29.32 ? 358 VAL A C 1 ATOM 2851 O O . VAL A 1 358 ? -15.179 19.454 19.495 1.00 29.61 ? 358 VAL A O 1 ATOM 2852 C CB . VAL A 1 358 ? -15.940 16.459 19.736 1.00 29.28 ? 358 VAL A CB 1 ATOM 2853 C CG1 . VAL A 1 358 ? -16.992 16.560 18.646 1.00 28.32 ? 358 VAL A CG1 1 ATOM 2854 C CG2 . VAL A 1 358 ? -15.689 14.978 20.119 1.00 27.79 ? 358 VAL A CG2 1 ATOM 2855 N N . SER A 1 359 ? -14.910 18.655 17.440 1.00 29.85 ? 359 SER A N 1 ATOM 2856 C CA . SER A 1 359 ? -15.083 19.953 16.798 1.00 29.56 ? 359 SER A CA 1 ATOM 2857 C C . SER A 1 359 ? -16.357 20.017 15.968 1.00 30.50 ? 359 SER A C 1 ATOM 2858 O O . SER A 1 359 ? -16.862 19.001 15.453 1.00 29.49 ? 359 SER A O 1 ATOM 2859 C CB . SER A 1 359 ? -13.897 20.253 15.874 1.00 29.03 ? 359 SER A CB 1 ATOM 2860 O OG . SER A 1 359 ? -12.695 20.393 16.602 1.00 27.01 ? 359 SER A OG 1 ATOM 2861 N N . ARG A 1 360 ? -16.853 21.239 15.827 1.00 31.73 ? 360 ARG A N 1 ATOM 2862 C CA . ARG A 1 360 ? -17.864 21.538 14.860 1.00 33.29 ? 360 ARG A CA 1 ATOM 2863 C C . ARG A 1 360 ? -17.068 22.234 13.782 1.00 34.75 ? 360 ARG A C 1 ATOM 2864 O O . ARG A 1 360 ? -16.265 23.111 14.076 1.00 35.64 ? 360 ARG A O 1 ATOM 2865 C CB . ARG A 1 360 ? -18.984 22.355 15.499 1.00 33.09 ? 360 ARG A CB 1 ATOM 2866 C CG . ARG A 1 360 ? -19.857 21.594 16.482 1.00 32.37 ? 360 ARG A CG 1 ATOM 2867 C CD . ARG A 1 360 ? -19.271 21.643 17.903 1.00 32.89 ? 360 ARG A CD 1 ATOM 2868 N NE . ARG A 1 360 ? -19.275 22.990 18.506 1.00 31.71 ? 360 ARG A NE 1 ATOM 2869 C CZ . ARG A 1 360 ? -20.319 23.526 19.140 1.00 31.94 ? 360 ARG A CZ 1 ATOM 2870 N NH1 . ARG A 1 360 ? -21.466 22.859 19.250 1.00 33.62 ? 360 ARG A NH1 1 ATOM 2871 N NH2 . ARG A 1 360 ? -20.232 24.732 19.670 1.00 31.95 ? 360 ARG A NH2 1 ATOM 2872 N N . LEU A 1 361 ? -17.264 21.836 12.530 1.00 36.38 ? 361 LEU A N 1 ATOM 2873 C CA . LEU A 1 361 ? -16.707 22.568 11.393 1.00 37.59 ? 361 LEU A CA 1 ATOM 2874 C C . LEU A 1 361 ? -17.809 23.124 10.490 1.00 38.53 ? 361 LEU A C 1 ATOM 2875 O O . LEU A 1 361 ? -18.852 22.504 10.313 1.00 38.73 ? 361 LEU A O 1 ATOM 2876 C CB . LEU A 1 361 ? -15.753 21.679 10.593 1.00 37.46 ? 361 LEU A CB 1 ATOM 2877 C CG . LEU A 1 361 ? -14.696 20.837 11.325 1.00 37.75 ? 361 LEU A CG 1 ATOM 2878 C CD1 . LEU A 1 361 ? -14.069 19.857 10.368 1.00 35.52 ? 361 LEU A CD1 1 ATOM 2879 C CD2 . LEU A 1 361 ? -13.600 21.652 12.041 1.00 36.25 ? 361 LEU A CD2 1 ATOM 2880 N N . ASP A 1 362 ? -17.585 24.297 9.909 1.00 40.53 ? 362 ASP A N 1 ATOM 2881 C CA . ASP A 1 362 ? -18.614 24.896 9.035 1.00 41.90 ? 362 ASP A CA 1 ATOM 2882 C C . ASP A 1 362 ? -18.495 24.389 7.595 1.00 42.46 ? 362 ASP A C 1 ATOM 2883 O O . ASP A 1 362 ? -17.659 23.538 7.305 1.00 42.11 ? 362 ASP A O 1 ATOM 2884 C CB . ASP A 1 362 ? -18.652 26.443 9.148 1.00 41.95 ? 362 ASP A CB 1 ATOM 2885 C CG . ASP A 1 362 ? -17.459 27.124 8.482 1.00 42.68 ? 362 ASP A CG 1 ATOM 2886 O OD1 . ASP A 1 362 ? -16.548 26.408 8.007 1.00 40.10 ? 362 ASP A OD1 1 ATOM 2887 O OD2 . ASP A 1 362 ? -17.429 28.392 8.464 1.00 46.16 ? 362 ASP A OD2 1 ATOM 2888 N N . GLU A 1 363 ? -19.315 24.950 6.704 1.00 43.55 ? 363 GLU A N 1 ATOM 2889 C CA . GLU A 1 363 ? -19.273 24.645 5.270 1.00 44.10 ? 363 GLU A CA 1 ATOM 2890 C C . GLU A 1 363 ? -17.928 24.591 4.575 1.00 44.24 ? 363 GLU A C 1 ATOM 2891 O O . GLU A 1 363 ? -17.812 23.921 3.574 1.00 44.86 ? 363 GLU A O 1 ATOM 2892 C CB . GLU A 1 363 ? -20.161 25.587 4.509 1.00 44.13 ? 363 GLU A CB 1 ATOM 2893 C CG . GLU A 1 363 ? -21.518 25.017 4.282 1.00 45.82 ? 363 GLU A CG 1 ATOM 2894 C CD . GLU A 1 363 ? -22.467 25.295 5.417 1.00 47.42 ? 363 GLU A CD 1 ATOM 2895 O OE1 . GLU A 1 363 ? -22.039 25.886 6.449 1.00 46.25 ? 363 GLU A OE1 1 ATOM 2896 O OE2 . GLU A 1 363 ? -23.658 24.929 5.240 1.00 49.00 ? 363 GLU A OE2 1 ATOM 2897 N N . ASN A 1 364 ? -16.928 25.306 5.078 1.00 44.58 ? 364 ASN A N 1 ATOM 2898 C CA . ASN A 1 364 ? -15.590 25.281 4.470 1.00 44.63 ? 364 ASN A CA 1 ATOM 2899 C C . ASN A 1 364 ? -14.607 24.431 5.240 1.00 44.42 ? 364 ASN A C 1 ATOM 2900 O O . ASN A 1 364 ? -13.400 24.466 4.972 1.00 44.83 ? 364 ASN A O 1 ATOM 2901 C CB . ASN A 1 364 ? -15.036 26.700 4.296 1.00 45.13 ? 364 ASN A CB 1 ATOM 2902 C CG . ASN A 1 364 ? -15.634 27.415 3.088 1.00 45.69 ? 364 ASN A CG 1 ATOM 2903 O OD1 . ASN A 1 364 ? -16.465 28.315 3.228 1.00 45.51 ? 364 ASN A OD1 1 ATOM 2904 N ND2 . ASN A 1 364 ? -15.228 26.992 1.891 1.00 46.78 ? 364 ASN A ND2 1 ATOM 2905 N N . TYR A 1 365 ? -15.137 23.662 6.188 1.00 43.98 ? 365 TYR A N 1 ATOM 2906 C CA . TYR A 1 365 ? -14.353 22.802 7.087 1.00 43.49 ? 365 TYR A CA 1 ATOM 2907 C C . TYR A 1 365 ? -13.404 23.615 7.985 1.00 43.31 ? 365 TYR A C 1 ATOM 2908 O O . TYR A 1 365 ? -12.359 23.151 8.446 1.00 42.60 ? 365 TYR A O 1 ATOM 2909 C CB . TYR A 1 365 ? -13.673 21.658 6.319 1.00 43.20 ? 365 TYR A CB 1 ATOM 2910 C CG . TYR A 1 365 ? -14.648 20.570 5.875 1.00 42.70 ? 365 TYR A CG 1 ATOM 2911 C CD1 . TYR A 1 365 ? -14.611 19.302 6.453 1.00 41.65 ? 365 TYR A CD1 1 ATOM 2912 C CD2 . TYR A 1 365 ? -15.615 20.817 4.901 1.00 41.22 ? 365 TYR A CD2 1 ATOM 2913 C CE1 . TYR A 1 365 ? -15.491 18.297 6.065 1.00 40.82 ? 365 TYR A CE1 1 ATOM 2914 C CE2 . TYR A 1 365 ? -16.500 19.824 4.497 1.00 41.64 ? 365 TYR A CE2 1 ATOM 2915 C CZ . TYR A 1 365 ? -16.432 18.548 5.078 1.00 41.90 ? 365 TYR A CZ 1 ATOM 2916 O OH . TYR A 1 365 ? -17.305 17.534 4.694 1.00 37.58 ? 365 TYR A OH 1 ATOM 2917 N N . GLN A 1 366 ? -13.827 24.850 8.225 1.00 43.54 ? 366 GLN A N 1 ATOM 2918 C CA . GLN A 1 366 ? -13.193 25.726 9.186 1.00 43.89 ? 366 GLN A CA 1 ATOM 2919 C C . GLN A 1 366 ? -13.973 25.766 10.519 1.00 43.12 ? 366 GLN A C 1 ATOM 2920 O O . GLN A 1 366 ? -15.186 25.485 10.554 1.00 41.98 ? 366 GLN A O 1 ATOM 2921 C CB . GLN A 1 366 ? -13.031 27.134 8.587 1.00 44.41 ? 366 GLN A CB 1 ATOM 2922 C CG . GLN A 1 366 ? -11.926 27.249 7.519 1.00 46.40 ? 366 GLN A CG 1 ATOM 2923 C CD . GLN A 1 366 ? -10.579 26.695 7.984 1.00 49.63 ? 366 GLN A CD 1 ATOM 2924 O OE1 . GLN A 1 366 ? -10.149 26.918 9.135 1.00 51.64 ? 366 GLN A OE1 1 ATOM 2925 N NE2 . GLN A 1 366 ? -9.900 25.972 7.089 1.00 48.45 ? 366 GLN A NE2 1 ATOM 2926 N N . PRO A 1 367 ? -13.261 26.095 11.611 1.00 42.89 ? 367 PRO A N 1 ATOM 2927 C CA . PRO A 1 367 ? -13.774 26.211 12.970 1.00 43.11 ? 367 PRO A CA 1 ATOM 2928 C C . PRO A 1 367 ? -15.147 26.887 13.111 1.00 43.31 ? 367 PRO A C 1 ATOM 2929 O O . PRO A 1 367 ? -15.221 28.104 13.185 1.00 44.40 ? 367 PRO A O 1 ATOM 2930 C CB . PRO A 1 367 ? -12.685 27.029 13.668 1.00 42.84 ? 367 PRO A CB 1 ATOM 2931 C CG . PRO A 1 367 ? -11.380 26.641 12.938 1.00 42.51 ? 367 PRO A CG 1 ATOM 2932 C CD . PRO A 1 367 ? -11.780 26.050 11.605 1.00 43.30 ? 367 PRO A CD 1 ATOM 2933 N N . TRP A 1 368 ? -16.209 26.091 13.181 1.00 43.19 ? 368 TRP A N 1 ATOM 2934 C CA . TRP A 1 368 ? -17.573 26.595 13.353 1.00 43.20 ? 368 TRP A CA 1 ATOM 2935 C C . TRP A 1 368 ? -17.350 27.439 14.594 1.00 43.29 ? 368 TRP A C 1 ATOM 2936 O O . TRP A 1 368 ? -16.839 26.954 15.597 1.00 43.28 ? 368 TRP A O 1 ATOM 2937 C CB . TRP A 1 368 ? -18.598 25.448 13.321 1.00 42.86 ? 368 TRP A CB 1 ATOM 2938 C CG . TRP A 1 368 ? -20.028 25.911 13.213 1.00 42.17 ? 368 TRP A CG 1 ATOM 2939 C CD1 . TRP A 1 368 ? -20.610 26.483 12.133 1.00 42.60 ? 368 TRP A CD1 1 ATOM 2940 C CD2 . TRP A 1 368 ? -21.052 25.818 14.220 1.00 41.53 ? 368 TRP A CD2 1 ATOM 2941 N NE1 . TRP A 1 368 ? -21.925 26.772 12.399 1.00 42.76 ? 368 TRP A NE1 1 ATOM 2942 C CE2 . TRP A 1 368 ? -22.224 26.371 13.671 1.00 40.99 ? 368 TRP A CE2 1 ATOM 2943 C CE3 . TRP A 1 368 ? -21.085 25.333 15.532 1.00 41.79 ? 368 TRP A CE3 1 ATOM 2944 C CZ2 . TRP A 1 368 ? -23.423 26.457 14.384 1.00 40.73 ? 368 TRP A CZ2 1 ATOM 2945 C CZ3 . TRP A 1 368 ? -22.285 25.406 16.241 1.00 41.46 ? 368 TRP A CZ3 1 ATOM 2946 C CH2 . TRP A 1 368 ? -23.437 25.966 15.659 1.00 41.96 ? 368 TRP A CH2 1 ATOM 2947 N N . GLY A 1 369 ? -17.739 28.711 14.499 1.00 43.64 ? 369 GLY A N 1 ATOM 2948 C CA . GLY A 1 369 ? -18.082 29.624 15.579 1.00 43.77 ? 369 GLY A CA 1 ATOM 2949 C C . GLY A 1 369 ? -16.987 29.891 16.596 1.00 43.80 ? 369 GLY A C 1 ATOM 2950 O O . GLY A 1 369 ? -15.814 29.600 16.357 1.00 44.64 ? 369 GLY A O 1 ATOM 2951 N N . PRO A 1 370 ? -17.368 30.440 17.755 1.00 43.31 ? 370 PRO A N 1 ATOM 2952 C CA . PRO A 1 370 ? -16.367 30.864 18.734 1.00 43.22 ? 370 PRO A CA 1 ATOM 2953 C C . PRO A 1 370 ? -16.085 29.706 19.706 1.00 42.79 ? 370 PRO A C 1 ATOM 2954 O O . PRO A 1 370 ? -15.158 29.814 20.522 1.00 44.00 ? 370 PRO A O 1 ATOM 2955 C CB . PRO A 1 370 ? -16.990 32.051 19.470 1.00 42.98 ? 370 PRO A CB 1 ATOM 2956 C CG . PRO A 1 370 ? -18.482 31.797 19.377 1.00 43.62 ? 370 PRO A CG 1 ATOM 2957 C CD . PRO A 1 370 ? -18.704 31.064 18.046 1.00 43.51 ? 370 PRO A CD 1 ATOM 2958 N N . GLU A 1 371 ? -16.871 28.629 19.619 1.00 41.20 ? 371 GLU A N 1 ATOM 2959 C CA . GLU A 1 371 ? -16.683 27.417 20.421 1.00 39.63 ? 371 GLU A CA 1 ATOM 2960 C C . GLU A 1 371 ? -16.461 26.184 19.573 1.00 38.02 ? 371 GLU A C 1 ATOM 2961 O O . GLU A 1 371 ? -16.944 25.125 19.924 1.00 37.38 ? 371 GLU A O 1 ATOM 2962 C CB . GLU A 1 371 ? -17.923 27.137 21.252 1.00 40.07 ? 371 GLU A CB 1 ATOM 2963 C CG . GLU A 1 371 ? -17.789 27.471 22.691 1.00 42.24 ? 371 GLU A CG 1 ATOM 2964 C CD . GLU A 1 371 ? -17.967 28.930 22.951 1.00 46.16 ? 371 GLU A CD 1 ATOM 2965 O OE1 . GLU A 1 371 ? -17.182 29.717 22.376 1.00 47.20 ? 371 GLU A OE1 1 ATOM 2966 O OE2 . GLU A 1 371 ? -18.884 29.288 23.742 1.00 49.39 ? 371 GLU A OE2 1 ATOM 2967 N N . ALA A 1 372 ? -15.758 26.325 18.454 1.00 36.57 ? 372 ALA A N 1 ATOM 2968 C CA . ALA A 1 372 ? -15.620 25.228 17.503 1.00 35.18 ? 372 ALA A CA 1 ATOM 2969 C C . ALA A 1 372 ? -15.247 23.910 18.187 1.00 34.62 ? 372 ALA A C 1 ATOM 2970 O O . ALA A 1 372 ? -15.965 22.913 18.051 1.00 33.86 ? 372 ALA A O 1 ATOM 2971 C CB . ALA A 1 372 ? -14.607 25.567 16.431 1.00 34.28 ? 372 ALA A CB 1 ATOM 2972 N N . GLU A 1 373 ? -14.142 23.934 18.937 1.00 33.89 ? 373 GLU A N 1 ATOM 2973 C CA . GLU A 1 373 ? -13.539 22.741 19.459 1.00 33.30 ? 373 GLU A CA 1 ATOM 2974 C C . GLU A 1 373 ? -13.854 22.629 20.934 1.00 32.54 ? 373 GLU A C 1 ATOM 2975 O O . GLU A 1 373 ? -13.412 23.473 21.716 1.00 32.62 ? 373 GLU A O 1 ATOM 2976 C CB . GLU A 1 373 ? -12.024 22.764 19.212 1.00 34.11 ? 373 GLU A CB 1 ATOM 2977 C CG . GLU A 1 373 ? -11.219 21.624 19.914 1.00 36.46 ? 373 GLU A CG 1 ATOM 2978 C CD . GLU A 1 373 ? -9.709 21.671 19.632 1.00 42.03 ? 373 GLU A CD 1 ATOM 2979 O OE1 . GLU A 1 373 ? -9.221 22.676 19.058 1.00 43.86 ? 373 GLU A OE1 1 ATOM 2980 O OE2 . GLU A 1 373 ? -8.996 20.691 19.978 1.00 44.11 ? 373 GLU A OE2 1 ATOM 2981 N N . LEU A 1 374 ? -14.570 21.557 21.302 1.00 31.23 ? 374 LEU A N 1 ATOM 2982 C CA . LEU A 1 374 ? -15.032 21.299 22.670 1.00 30.26 ? 374 LEU A CA 1 ATOM 2983 C C . LEU A 1 374 ? -14.309 20.135 23.392 1.00 29.94 ? 374 LEU A C 1 ATOM 2984 O O . LEU A 1 374 ? -14.063 19.103 22.790 1.00 31.03 ? 374 LEU A O 1 ATOM 2985 C CB . LEU A 1 374 ? -16.523 20.994 22.619 1.00 30.24 ? 374 LEU A CB 1 ATOM 2986 C CG . LEU A 1 374 ? -17.438 22.034 21.966 1.00 29.91 ? 374 LEU A CG 1 ATOM 2987 C CD1 . LEU A 1 374 ? -18.837 21.477 21.730 1.00 28.96 ? 374 LEU A CD1 1 ATOM 2988 C CD2 . LEU A 1 374 ? -17.481 23.313 22.808 1.00 30.22 ? 374 LEU A CD2 1 ATOM 2989 N N . PRO A 1 375 ? -13.994 20.278 24.691 1.00 28.82 ? 375 PRO A N 1 ATOM 2990 C CA . PRO A 1 375 ? -13.394 19.119 25.357 1.00 27.87 ? 375 PRO A CA 1 ATOM 2991 C C . PRO A 1 375 ? -14.400 17.964 25.412 1.00 26.75 ? 375 PRO A C 1 ATOM 2992 O O . PRO A 1 375 ? -15.564 18.187 25.742 1.00 26.21 ? 375 PRO A O 1 ATOM 2993 C CB . PRO A 1 375 ? -13.107 19.609 26.787 1.00 27.08 ? 375 PRO A CB 1 ATOM 2994 C CG . PRO A 1 375 ? -13.587 21.017 26.864 1.00 27.77 ? 375 PRO A CG 1 ATOM 2995 C CD . PRO A 1 375 ? -14.420 21.307 25.658 1.00 29.45 ? 375 PRO A CD 1 ATOM 2996 N N . LEU A 1 376 ? -13.934 16.746 25.111 1.00 25.20 ? 376 LEU A N 1 ATOM 2997 C CA . LEU A 1 376 ? -14.785 15.585 25.145 1.00 24.17 ? 376 LEU A CA 1 ATOM 2998 C C . LEU A 1 376 ? -15.643 15.450 26.405 1.00 24.18 ? 376 LEU A C 1 ATOM 2999 O O . LEU A 1 376 ? -16.783 15.005 26.310 1.00 24.99 ? 376 LEU A O 1 ATOM 3000 C CB . LEU A 1 376 ? -13.987 14.297 24.910 1.00 23.76 ? 376 LEU A CB 1 ATOM 3001 C CG . LEU A 1 376 ? -14.832 13.030 25.018 1.00 22.18 ? 376 LEU A CG 1 ATOM 3002 C CD1 . LEU A 1 376 ? -15.915 12.899 23.916 1.00 19.96 ? 376 LEU A CD1 1 ATOM 3003 C CD2 . LEU A 1 376 ? -13.947 11.826 25.063 1.00 19.61 ? 376 LEU A CD2 1 ATOM 3004 N N . HIS A 1 377 ? -15.132 15.790 27.582 1.00 23.13 ? 377 HIS A N 1 ATOM 3005 C CA . HIS A 1 377 ? -15.900 15.452 28.750 1.00 22.84 ? 377 HIS A CA 1 ATOM 3006 C C . HIS A 1 377 ? -17.243 16.186 28.817 1.00 24.17 ? 377 HIS A C 1 ATOM 3007 O O . HIS A 1 377 ? -18.183 15.664 29.413 1.00 25.31 ? 377 HIS A O 1 ATOM 3008 C CB . HIS A 1 377 ? -15.097 15.568 30.046 1.00 22.13 ? 377 HIS A CB 1 ATOM 3009 C CG . HIS A 1 377 ? -15.009 16.954 30.585 1.00 21.59 ? 377 HIS A CG 1 ATOM 3010 N ND1 . HIS A 1 377 ? -14.211 17.926 30.011 1.00 19.72 ? 377 HIS A ND1 1 ATOM 3011 C CD2 . HIS A 1 377 ? -15.626 17.537 31.640 1.00 18.66 ? 377 HIS A CD2 1 ATOM 3012 C CE1 . HIS A 1 377 ? -14.359 19.054 30.676 1.00 19.75 ? 377 HIS A CE1 1 ATOM 3013 N NE2 . HIS A 1 377 ? -15.200 18.839 31.679 1.00 21.88 ? 377 HIS A NE2 1 ATOM 3014 N N . THR A 1 378 ? -17.364 17.360 28.188 1.00 24.00 ? 378 THR A N 1 ATOM 3015 C CA . THR A 1 378 ? -18.627 18.103 28.262 1.00 24.01 ? 378 THR A CA 1 ATOM 3016 C C . THR A 1 378 ? -19.701 17.547 27.311 1.00 24.43 ? 378 THR A C 1 ATOM 3017 O O . THR A 1 378 ? -20.803 18.107 27.225 1.00 24.59 ? 378 THR A O 1 ATOM 3018 C CB . THR A 1 378 ? -18.450 19.600 27.952 1.00 24.27 ? 378 THR A CB 1 ATOM 3019 O OG1 . THR A 1 378 ? -18.248 19.772 26.548 1.00 24.50 ? 378 THR A OG1 1 ATOM 3020 C CG2 . THR A 1 378 ? -17.276 20.183 28.711 1.00 24.75 ? 378 THR A CG2 1 ATOM 3021 N N . LEU A 1 379 ? -19.392 16.446 26.615 1.00 23.90 ? 379 LEU A N 1 ATOM 3022 C CA . LEU A 1 379 ? -20.272 15.914 25.575 1.00 23.70 ? 379 LEU A CA 1 ATOM 3023 C C . LEU A 1 379 ? -20.888 14.581 25.974 1.00 24.43 ? 379 LEU A C 1 ATOM 3024 O O . LEU A 1 379 ? -21.591 13.977 25.177 1.00 25.09 ? 379 LEU A O 1 ATOM 3025 C CB . LEU A 1 379 ? -19.551 15.835 24.208 1.00 23.28 ? 379 LEU A CB 1 ATOM 3026 C CG . LEU A 1 379 ? -18.801 17.151 23.857 1.00 23.94 ? 379 LEU A CG 1 ATOM 3027 C CD1 . LEU A 1 379 ? -17.738 17.030 22.779 1.00 22.86 ? 379 LEU A CD1 1 ATOM 3028 C CD2 . LEU A 1 379 ? -19.745 18.270 23.502 1.00 25.38 ? 379 LEU A CD2 1 ATOM 3029 N N . PHE A 1 380 ? -20.640 14.119 27.204 1.00 25.24 ? 380 PHE A N 1 ATOM 3030 C CA . PHE A 1 380 ? -21.290 12.908 27.690 1.00 25.57 ? 380 PHE A CA 1 ATOM 3031 C C . PHE A 1 380 ? -22.754 13.212 28.012 1.00 27.18 ? 380 PHE A C 1 ATOM 3032 O O . PHE A 1 380 ? -23.080 14.138 28.795 1.00 27.28 ? 380 PHE A O 1 ATOM 3033 C CB . PHE A 1 380 ? -20.561 12.291 28.882 1.00 24.88 ? 380 PHE A CB 1 ATOM 3034 C CG . PHE A 1 380 ? -19.094 12.011 28.619 1.00 24.44 ? 380 PHE A CG 1 ATOM 3035 C CD1 . PHE A 1 380 ? -18.688 11.385 27.435 1.00 20.06 ? 380 PHE A CD1 1 ATOM 3036 C CD2 . PHE A 1 380 ? -18.116 12.404 29.545 1.00 23.84 ? 380 PHE A CD2 1 ATOM 3037 C CE1 . PHE A 1 380 ? -17.361 11.140 27.170 1.00 21.20 ? 380 PHE A CE1 1 ATOM 3038 C CE2 . PHE A 1 380 ? -16.765 12.171 29.289 1.00 24.55 ? 380 PHE A CE2 1 ATOM 3039 C CZ . PHE A 1 380 ? -16.379 11.529 28.086 1.00 23.41 ? 380 PHE A CZ 1 ATOM 3040 N N . PHE A 1 381 ? -23.647 12.454 27.378 1.00 27.64 ? 381 PHE A N 1 ATOM 3041 C CA . PHE A 1 381 ? -25.080 12.640 27.613 1.00 28.06 ? 381 PHE A CA 1 ATOM 3042 C C . PHE A 1 381 ? -25.488 14.072 27.280 1.00 28.79 ? 381 PHE A C 1 ATOM 3043 O O . PHE A 1 381 ? -26.484 14.594 27.774 1.00 29.32 ? 381 PHE A O 1 ATOM 3044 C CB . PHE A 1 381 ? -25.459 12.157 29.023 1.00 27.10 ? 381 PHE A CB 1 ATOM 3045 C CG . PHE A 1 381 ? -25.253 10.669 29.191 1.00 26.49 ? 381 PHE A CG 1 ATOM 3046 C CD1 . PHE A 1 381 ? -26.181 9.769 28.682 1.00 24.34 ? 381 PHE A CD1 1 ATOM 3047 C CD2 . PHE A 1 381 ? -24.095 10.166 29.766 1.00 27.39 ? 381 PHE A CD2 1 ATOM 3048 C CE1 . PHE A 1 381 ? -25.994 8.378 28.780 1.00 24.63 ? 381 PHE A CE1 1 ATOM 3049 C CE2 . PHE A 1 381 ? -23.894 8.765 29.864 1.00 27.65 ? 381 PHE A CE2 1 ATOM 3050 C CZ . PHE A 1 381 ? -24.868 7.873 29.366 1.00 25.49 ? 381 PHE A CZ 1 ATOM 3051 N N . ASN A 1 382 ? -24.698 14.686 26.401 1.00 29.02 ? 382 ASN A N 1 ATOM 3052 C CA . ASN A 1 382 ? -24.966 16.021 25.917 1.00 29.38 ? 382 ASN A CA 1 ATOM 3053 C C . ASN A 1 382 ? -25.767 15.991 24.619 1.00 29.29 ? 382 ASN A C 1 ATOM 3054 O O . ASN A 1 382 ? -25.205 15.882 23.544 1.00 30.82 ? 382 ASN A O 1 ATOM 3055 C CB . ASN A 1 382 ? -23.641 16.779 25.749 1.00 28.45 ? 382 ASN A CB 1 ATOM 3056 C CG . ASN A 1 382 ? -23.827 18.257 25.476 1.00 29.13 ? 382 ASN A CG 1 ATOM 3057 O OD1 . ASN A 1 382 ? -24.763 18.665 24.771 1.00 26.18 ? 382 ASN A OD1 1 ATOM 3058 N ND2 . ASN A 1 382 ? -22.896 19.081 26.003 1.00 26.31 ? 382 ASN A ND2 1 ATOM 3059 N N . THR A 1 383 ? -27.079 16.116 24.730 1.00 29.67 ? 383 THR A N 1 ATOM 3060 C CA . THR A 1 383 ? -27.962 16.280 23.570 1.00 29.71 ? 383 THR A CA 1 ATOM 3061 C C . THR A 1 383 ? -28.305 17.748 23.236 1.00 29.85 ? 383 THR A C 1 ATOM 3062 O O . THR A 1 383 ? -28.726 18.044 22.103 1.00 28.91 ? 383 THR A O 1 ATOM 3063 C CB . THR A 1 383 ? -29.266 15.474 23.740 1.00 30.29 ? 383 THR A CB 1 ATOM 3064 O OG1 . THR A 1 383 ? -29.951 15.886 24.937 1.00 31.48 ? 383 THR A OG1 1 ATOM 3065 C CG2 . THR A 1 383 ? -28.967 13.988 23.817 1.00 28.38 ? 383 THR A CG2 1 ATOM 3066 N N . TRP A 1 384 ? -28.108 18.672 24.189 1.00 29.70 ? 384 TRP A N 1 ATOM 3067 C CA . TRP A 1 384 ? -28.391 20.104 23.912 1.00 30.28 ? 384 TRP A CA 1 ATOM 3068 C C . TRP A 1 384 ? -27.494 20.785 22.892 1.00 30.87 ? 384 TRP A C 1 ATOM 3069 O O . TRP A 1 384 ? -27.936 21.703 22.191 1.00 30.48 ? 384 TRP A O 1 ATOM 3070 C CB . TRP A 1 384 ? -28.459 20.959 25.177 1.00 30.50 ? 384 TRP A CB 1 ATOM 3071 C CG . TRP A 1 384 ? -27.164 21.258 25.841 1.00 29.92 ? 384 TRP A CG 1 ATOM 3072 C CD1 . TRP A 1 384 ? -26.578 20.537 26.848 1.00 30.58 ? 384 TRP A CD1 1 ATOM 3073 C CD2 . TRP A 1 384 ? -26.313 22.376 25.607 1.00 29.88 ? 384 TRP A CD2 1 ATOM 3074 N NE1 . TRP A 1 384 ? -25.403 21.120 27.228 1.00 30.86 ? 384 TRP A NE1 1 ATOM 3075 C CE2 . TRP A 1 384 ? -25.210 22.251 26.487 1.00 29.69 ? 384 TRP A CE2 1 ATOM 3076 C CE3 . TRP A 1 384 ? -26.362 23.467 24.735 1.00 31.17 ? 384 TRP A CE3 1 ATOM 3077 C CZ2 . TRP A 1 384 ? -24.189 23.184 26.539 1.00 29.43 ? 384 TRP A CZ2 1 ATOM 3078 C CZ3 . TRP A 1 384 ? -25.330 24.392 24.769 1.00 30.61 ? 384 TRP A CZ3 1 ATOM 3079 C CH2 . TRP A 1 384 ? -24.263 24.248 25.676 1.00 32.35 ? 384 TRP A CH2 1 ATOM 3080 N N . ARG A 1 385 ? -26.240 20.354 22.806 1.00 31.09 ? 385 ARG A N 1 ATOM 3081 C CA . ARG A 1 385 ? -25.314 20.971 21.860 1.00 31.48 ? 385 ARG A CA 1 ATOM 3082 C C . ARG A 1 385 ? -25.653 20.617 20.411 1.00 31.07 ? 385 ARG A C 1 ATOM 3083 O O . ARG A 1 385 ? -25.265 21.311 19.497 1.00 30.89 ? 385 ARG A O 1 ATOM 3084 C CB . ARG A 1 385 ? -23.862 20.610 22.201 1.00 31.96 ? 385 ARG A CB 1 ATOM 3085 C CG . ARG A 1 385 ? -23.278 21.367 23.397 1.00 33.82 ? 385 ARG A CG 1 ATOM 3086 C CD . ARG A 1 385 ? -22.502 22.586 22.935 1.00 37.51 ? 385 ARG A CD 1 ATOM 3087 N NE . ARG A 1 385 ? -21.532 23.092 23.923 1.00 40.50 ? 385 ARG A NE 1 ATOM 3088 C CZ . ARG A 1 385 ? -20.923 24.274 23.821 1.00 39.70 ? 385 ARG A CZ 1 ATOM 3089 N NH1 . ARG A 1 385 ? -21.209 25.080 22.797 1.00 38.84 ? 385 ARG A NH1 1 ATOM 3090 N NH2 . ARG A 1 385 ? -20.043 24.661 24.739 1.00 36.93 ? 385 ARG A NH2 1 ATOM 3091 N N . ILE A 1 386 ? -26.377 19.526 20.208 1.00 31.13 ? 386 ILE A N 1 ATOM 3092 C CA . ILE A 1 386 ? -26.946 19.239 18.899 1.00 31.58 ? 386 ILE A CA 1 ATOM 3093 C C . ILE A 1 386 ? -28.150 20.152 18.573 1.00 32.09 ? 386 ILE A C 1 ATOM 3094 O O . ILE A 1 386 ? -28.098 20.962 17.629 1.00 31.52 ? 386 ILE A O 1 ATOM 3095 C CB . ILE A 1 386 ? -27.375 17.770 18.780 1.00 31.29 ? 386 ILE A CB 1 ATOM 3096 C CG1 . ILE A 1 386 ? -26.158 16.850 18.743 1.00 30.88 ? 386 ILE A CG1 1 ATOM 3097 C CG2 . ILE A 1 386 ? -28.172 17.560 17.530 1.00 32.19 ? 386 ILE A CG2 1 ATOM 3098 C CD1 . ILE A 1 386 ? -26.520 15.394 18.973 1.00 29.97 ? 386 ILE A CD1 1 ATOM 3099 N N . ILE A 1 387 ? -29.213 20.019 19.373 1.00 32.95 ? 387 ILE A N 1 ATOM 3100 C CA . ILE A 1 387 ? -30.494 20.669 19.093 1.00 34.03 ? 387 ILE A CA 1 ATOM 3101 C C . ILE A 1 387 ? -30.353 22.157 19.160 1.00 34.60 ? 387 ILE A C 1 ATOM 3102 O O . ILE A 1 387 ? -30.584 22.841 18.168 1.00 35.14 ? 387 ILE A O 1 ATOM 3103 C CB . ILE A 1 387 ? -31.651 20.184 20.033 1.00 33.91 ? 387 ILE A CB 1 ATOM 3104 C CG1 . ILE A 1 387 ? -32.117 18.809 19.595 1.00 33.58 ? 387 ILE A CG1 1 ATOM 3105 C CG2 . ILE A 1 387 ? -32.875 21.152 20.013 1.00 34.40 ? 387 ILE A CG2 1 ATOM 3106 C CD1 . ILE A 1 387 ? -31.599 17.723 20.478 1.00 36.55 ? 387 ILE A CD1 1 ATOM 3107 N N . LYS A 1 388 ? -29.935 22.639 20.321 1.00 35.35 ? 388 LYS A N 1 ATOM 3108 C CA . LYS A 1 388 ? -29.818 24.064 20.569 1.00 36.25 ? 388 LYS A CA 1 ATOM 3109 C C . LYS A 1 388 ? -28.538 24.704 20.086 1.00 36.41 ? 388 LYS A C 1 ATOM 3110 O O . LYS A 1 388 ? -28.402 25.918 20.227 1.00 37.95 ? 388 LYS A O 1 ATOM 3111 C CB . LYS A 1 388 ? -30.035 24.371 22.055 1.00 36.42 ? 388 LYS A CB 1 ATOM 3112 C CG . LYS A 1 388 ? -31.464 24.754 22.362 1.00 36.90 ? 388 LYS A CG 1 ATOM 3113 C CD . LYS A 1 388 ? -32.058 23.850 23.423 1.00 40.25 ? 388 LYS A CD 1 ATOM 3114 C CE . LYS A 1 388 ? -33.529 24.193 23.694 1.00 42.88 ? 388 LYS A CE 1 ATOM 3115 N NZ . LYS A 1 388 ? -33.688 25.499 24.435 1.00 43.73 ? 388 LYS A NZ 1 ATOM 3116 N N . ASP A 1 389 ? -27.626 23.920 19.515 1.00 35.97 ? 389 ASP A N 1 ATOM 3117 C CA . ASP A 1 389 ? -26.331 24.453 19.100 1.00 35.53 ? 389 ASP A CA 1 ATOM 3118 C C . ASP A 1 389 ? -25.805 23.943 17.755 1.00 35.41 ? 389 ASP A C 1 ATOM 3119 O O . ASP A 1 389 ? -24.670 23.474 17.670 1.00 35.52 ? 389 ASP A O 1 ATOM 3120 C CB . ASP A 1 389 ? -25.285 24.205 20.191 1.00 35.93 ? 389 ASP A CB 1 ATOM 3121 C CG . ASP A 1 389 ? -24.054 25.075 20.026 1.00 37.08 ? 389 ASP A CG 1 ATOM 3122 O OD1 . ASP A 1 389 ? -22.961 24.649 20.454 1.00 38.30 ? 389 ASP A OD1 1 ATOM 3123 O OD2 . ASP A 1 389 ? -24.180 26.185 19.468 1.00 39.26 ? 389 ASP A OD2 1 ATOM 3124 N N . GLY A 1 390 ? -26.615 24.049 16.705 1.00 34.88 ? 390 GLY A N 1 ATOM 3125 C CA . GLY A 1 390 ? -26.123 23.802 15.332 1.00 33.66 ? 390 GLY A CA 1 ATOM 3126 C C . GLY A 1 390 ? -26.633 22.648 14.471 1.00 32.88 ? 390 GLY A C 1 ATOM 3127 O O . GLY A 1 390 ? -26.452 22.667 13.260 1.00 33.71 ? 390 GLY A O 1 ATOM 3128 N N . GLY A 1 391 ? -27.271 21.648 15.057 1.00 31.70 ? 391 GLY A N 1 ATOM 3129 C CA . GLY A 1 391 ? -27.613 20.443 14.290 1.00 31.32 ? 391 GLY A CA 1 ATOM 3130 C C . GLY A 1 391 ? -26.504 19.396 14.327 1.00 30.57 ? 391 GLY A C 1 ATOM 3131 O O . GLY A 1 391 ? -25.638 19.480 15.168 1.00 30.80 ? 391 GLY A O 1 ATOM 3132 N N . ILE A 1 392 ? -26.504 18.415 13.430 1.00 29.65 ? 392 ILE A N 1 ATOM 3133 C CA . ILE A 1 392 ? -25.483 17.385 13.529 1.00 30.31 ? 392 ILE A CA 1 ATOM 3134 C C . ILE A 1 392 ? -24.416 17.642 12.469 1.00 30.97 ? 392 ILE A C 1 ATOM 3135 O O . ILE A 1 392 ? -23.334 17.024 12.510 1.00 31.51 ? 392 ILE A O 1 ATOM 3136 C CB . ILE A 1 392 ? -25.928 15.899 13.414 1.00 30.40 ? 392 ILE A CB 1 ATOM 3137 C CG1 . ILE A 1 392 ? -26.392 15.622 11.969 1.00 30.55 ? 392 ILE A CG1 1 ATOM 3138 C CG2 . ILE A 1 392 ? -26.920 15.513 14.546 1.00 28.84 ? 392 ILE A CG2 1 ATOM 3139 C CD1 . ILE A 1 392 ? -27.317 14.450 11.823 1.00 30.50 ? 392 ILE A CD1 1 ATOM 3140 N N . ASP A 1 393 ? -24.704 18.533 11.535 1.00 30.74 ? 393 ASP A N 1 ATOM 3141 C CA . ASP A 1 393 ? -23.881 18.683 10.355 1.00 31.70 ? 393 ASP A CA 1 ATOM 3142 C C . ASP A 1 393 ? -22.445 19.131 10.650 1.00 32.11 ? 393 ASP A C 1 ATOM 3143 O O . ASP A 1 393 ? -21.489 18.545 10.098 1.00 32.13 ? 393 ASP A O 1 ATOM 3144 C CB . ASP A 1 393 ? -24.575 19.574 9.326 1.00 32.26 ? 393 ASP A CB 1 ATOM 3145 C CG . ASP A 1 393 ? -25.588 18.797 8.447 1.00 36.01 ? 393 ASP A CG 1 ATOM 3146 O OD1 . ASP A 1 393 ? -26.554 18.140 8.964 1.00 39.19 ? 393 ASP A OD1 1 ATOM 3147 O OD2 . ASP A 1 393 ? -25.413 18.862 7.209 1.00 39.57 ? 393 ASP A OD2 1 ATOM 3148 N N . PRO A 1 394 ? -22.263 20.154 11.526 1.00 31.73 ? 394 PRO A N 1 ATOM 3149 C CA . PRO A 1 394 ? -20.859 20.496 11.792 1.00 31.59 ? 394 PRO A CA 1 ATOM 3150 C C . PRO A 1 394 ? -20.102 19.388 12.525 1.00 31.72 ? 394 PRO A C 1 ATOM 3151 O O . PRO A 1 394 ? -18.871 19.288 12.403 1.00 33.34 ? 394 PRO A O 1 ATOM 3152 C CB . PRO A 1 394 ? -20.943 21.763 12.661 1.00 31.85 ? 394 PRO A CB 1 ATOM 3153 C CG . PRO A 1 394 ? -22.382 22.254 12.545 1.00 32.12 ? 394 PRO A CG 1 ATOM 3154 C CD . PRO A 1 394 ? -23.206 21.046 12.228 1.00 31.16 ? 394 PRO A CD 1 ATOM 3155 N N . LEU A 1 395 ? -20.807 18.550 13.272 1.00 30.66 ? 395 LEU A N 1 ATOM 3156 C CA . LEU A 1 395 ? -20.150 17.491 14.006 1.00 29.75 ? 395 LEU A CA 1 ATOM 3157 C C . LEU A 1 395 ? -19.705 16.400 13.024 1.00 29.74 ? 395 LEU A C 1 ATOM 3158 O O . LEU A 1 395 ? -18.580 15.863 13.127 1.00 29.11 ? 395 LEU A O 1 ATOM 3159 C CB . LEU A 1 395 ? -21.077 16.924 15.075 1.00 29.63 ? 395 LEU A CB 1 ATOM 3160 C CG . LEU A 1 395 ? -21.491 17.823 16.251 1.00 29.08 ? 395 LEU A CG 1 ATOM 3161 C CD1 . LEU A 1 395 ? -22.764 17.326 16.883 1.00 25.97 ? 395 LEU A CD1 1 ATOM 3162 C CD2 . LEU A 1 395 ? -20.382 17.858 17.270 1.00 30.09 ? 395 LEU A CD2 1 ATOM 3163 N N . VAL A 1 396 ? -20.584 16.095 12.061 1.00 29.45 ? 396 VAL A N 1 ATOM 3164 C CA . VAL A 1 396 ? -20.280 15.119 11.022 1.00 29.17 ? 396 VAL A CA 1 ATOM 3165 C C . VAL A 1 396 ? -19.037 15.584 10.224 1.00 29.22 ? 396 VAL A C 1 ATOM 3166 O O . VAL A 1 396 ? -18.085 14.820 10.057 1.00 29.32 ? 396 VAL A O 1 ATOM 3167 C CB . VAL A 1 396 ? -21.492 14.850 10.105 1.00 29.13 ? 396 VAL A CB 1 ATOM 3168 C CG1 . VAL A 1 396 ? -21.079 13.956 8.949 1.00 30.03 ? 396 VAL A CG1 1 ATOM 3169 C CG2 . VAL A 1 396 ? -22.637 14.227 10.873 1.00 29.11 ? 396 VAL A CG2 1 ATOM 3170 N N . ARG A 1 397 ? -19.025 16.846 9.799 1.00 29.01 ? 397 ARG A N 1 ATOM 3171 C CA . ARG A 1 397 ? -17.852 17.435 9.141 1.00 29.48 ? 397 ARG A CA 1 ATOM 3172 C C . ARG A 1 397 ? -16.615 17.150 9.942 1.00 28.47 ? 397 ARG A C 1 ATOM 3173 O O . ARG A 1 397 ? -15.617 16.697 9.395 1.00 28.36 ? 397 ARG A O 1 ATOM 3174 C CB . ARG A 1 397 ? -18.004 18.954 8.914 1.00 29.86 ? 397 ARG A CB 1 ATOM 3175 C CG . ARG A 1 397 ? -19.083 19.302 7.910 1.00 31.47 ? 397 ARG A CG 1 ATOM 3176 C CD . ARG A 1 397 ? -19.015 20.757 7.417 1.00 34.22 ? 397 ARG A CD 1 ATOM 3177 N NE . ARG A 1 397 ? -20.258 21.117 6.742 1.00 34.67 ? 397 ARG A NE 1 ATOM 3178 C CZ . ARG A 1 397 ? -21.333 21.605 7.361 1.00 39.05 ? 397 ARG A CZ 1 ATOM 3179 N NH1 . ARG A 1 397 ? -21.315 21.823 8.688 1.00 37.75 ? 397 ARG A NH1 1 ATOM 3180 N NH2 . ARG A 1 397 ? -22.430 21.895 6.649 1.00 40.37 ? 397 ARG A NH2 1 ATOM 3181 N N . GLY A 1 398 ? -16.695 17.382 11.244 1.00 28.05 ? 398 GLY A N 1 ATOM 3182 C CA . GLY A 1 398 ? -15.642 16.930 12.158 1.00 27.94 ? 398 GLY A CA 1 ATOM 3183 C C . GLY A 1 398 ? -15.228 15.476 11.946 1.00 27.92 ? 398 GLY A C 1 ATOM 3184 O O . GLY A 1 398 ? -14.090 15.206 11.576 1.00 27.35 ? 398 GLY A O 1 ATOM 3185 N N . LEU A 1 399 ? -16.165 14.552 12.160 1.00 28.39 ? 399 LEU A N 1 ATOM 3186 C CA . LEU A 1 399 ? -15.953 13.112 11.909 1.00 28.81 ? 399 LEU A CA 1 ATOM 3187 C C . LEU A 1 399 ? -15.118 12.861 10.650 1.00 29.44 ? 399 LEU A C 1 ATOM 3188 O O . LEU A 1 399 ? -14.190 12.044 10.681 1.00 30.01 ? 399 LEU A O 1 ATOM 3189 C CB . LEU A 1 399 ? -17.283 12.331 11.853 1.00 28.21 ? 399 LEU A CB 1 ATOM 3190 C CG . LEU A 1 399 ? -18.109 12.123 13.133 1.00 26.82 ? 399 LEU A CG 1 ATOM 3191 C CD1 . LEU A 1 399 ? -19.569 11.766 12.852 1.00 25.84 ? 399 LEU A CD1 1 ATOM 3192 C CD2 . LEU A 1 399 ? -17.495 11.024 13.960 1.00 25.41 ? 399 LEU A CD2 1 ATOM 3193 N N . LEU A 1 400 ? -15.391 13.580 9.561 1.00 30.00 ? 400 LEU A N 1 ATOM 3194 C CA . LEU A 1 400 ? -14.538 13.431 8.347 1.00 30.43 ? 400 LEU A CA 1 ATOM 3195 C C . LEU A 1 400 ? -13.190 14.124 8.457 1.00 30.78 ? 400 LEU A C 1 ATOM 3196 O O . LEU A 1 400 ? -12.138 13.537 8.198 1.00 31.26 ? 400 LEU A O 1 ATOM 3197 C CB . LEU A 1 400 ? -15.244 13.941 7.088 1.00 30.17 ? 400 LEU A CB 1 ATOM 3198 C CG . LEU A 1 400 ? -16.572 13.326 6.656 1.00 30.41 ? 400 LEU A CG 1 ATOM 3199 C CD1 . LEU A 1 400 ? -17.229 14.184 5.578 1.00 29.90 ? 400 LEU A CD1 1 ATOM 3200 C CD2 . LEU A 1 400 ? -16.418 11.850 6.225 1.00 32.14 ? 400 LEU A CD2 1 ATOM 3201 N N . ALA A 1 401 ? -13.221 15.395 8.838 1.00 31.60 ? 401 ALA A N 1 ATOM 3202 C CA . ALA A 1 401 ? -12.031 16.245 8.706 1.00 31.49 ? 401 ALA A CA 1 ATOM 3203 C C . ALA A 1 401 ? -11.017 16.057 9.799 1.00 31.32 ? 401 ALA A C 1 ATOM 3204 O O . ALA A 1 401 ? -9.888 16.479 9.638 1.00 32.52 ? 401 ALA A O 1 ATOM 3205 C CB . ALA A 1 401 ? -12.420 17.706 8.554 1.00 30.73 ? 401 ALA A CB 1 ATOM 3206 N N . LYS A 1 402 ? -11.416 15.394 10.887 1.00 31.78 ? 402 LYS A N 1 ATOM 3207 C CA . LYS A 1 402 ? -10.606 15.222 12.109 1.00 30.99 ? 402 LYS A CA 1 ATOM 3208 C C . LYS A 1 402 ? -10.130 13.786 12.284 1.00 30.50 ? 402 LYS A C 1 ATOM 3209 O O . LYS A 1 402 ? -10.673 12.874 11.675 1.00 30.20 ? 402 LYS A O 1 ATOM 3210 C CB . LYS A 1 402 ? -11.437 15.600 13.336 1.00 31.19 ? 402 LYS A CB 1 ATOM 3211 C CG . LYS A 1 402 ? -11.687 17.096 13.509 1.00 33.79 ? 402 LYS A CG 1 ATOM 3212 C CD . LYS A 1 402 ? -10.399 17.872 13.848 1.00 36.95 ? 402 LYS A CD 1 ATOM 3213 C CE . LYS A 1 402 ? -10.610 18.885 14.991 1.00 38.45 ? 402 LYS A CE 1 ATOM 3214 N NZ . LYS A 1 402 ? -10.451 18.347 16.414 1.00 38.65 ? 402 LYS A NZ 1 ATOM 3215 N N . LYS A 1 403 ? -9.155 13.591 13.168 1.00 30.23 ? 403 LYS A N 1 ATOM 3216 C CA . LYS A 1 403 ? -8.503 12.306 13.350 1.00 29.65 ? 403 LYS A CA 1 ATOM 3217 C C . LYS A 1 403 ? -8.824 11.622 14.673 1.00 29.49 ? 403 LYS A C 1 ATOM 3218 O O . LYS A 1 403 ? -9.028 12.289 15.677 1.00 30.22 ? 403 LYS A O 1 ATOM 3219 C CB . LYS A 1 403 ? -6.994 12.506 13.223 1.00 29.75 ? 403 LYS A CB 1 ATOM 3220 C CG . LYS A 1 403 ? -6.580 12.916 11.822 1.00 30.74 ? 403 LYS A CG 1 ATOM 3221 C CD . LYS A 1 403 ? -5.094 13.309 11.722 1.00 32.33 ? 403 LYS A CD 1 ATOM 3222 C CE . LYS A 1 403 ? -4.688 13.654 10.272 1.00 30.80 ? 403 LYS A CE 1 ATOM 3223 N NZ . LYS A 1 403 ? -5.795 14.179 9.394 1.00 30.00 ? 403 LYS A NZ 1 ATOM 3224 N N . SER A 1 404 ? -8.885 10.284 14.671 1.00 29.20 ? 404 SER A N 1 ATOM 3225 C CA . SER A 1 404 ? -8.970 9.501 15.917 1.00 27.71 ? 404 SER A CA 1 ATOM 3226 C C . SER A 1 404 ? -7.650 9.687 16.655 1.00 27.37 ? 404 SER A C 1 ATOM 3227 O O . SER A 1 404 ? -6.654 10.082 16.059 1.00 27.04 ? 404 SER A O 1 ATOM 3228 C CB . SER A 1 404 ? -9.142 7.991 15.647 1.00 27.20 ? 404 SER A CB 1 ATOM 3229 O OG . SER A 1 404 ? -10.345 7.667 15.000 1.00 27.20 ? 404 SER A OG 1 ATOM 3230 N N . LYS A 1 405 ? -7.658 9.388 17.951 1.00 26.78 ? 405 LYS A N 1 ATOM 3231 C CA . LYS A 1 405 ? -6.439 9.204 18.687 1.00 26.09 ? 405 LYS A CA 1 ATOM 3232 C C . LYS A 1 405 ? -5.800 7.889 18.234 1.00 26.30 ? 405 LYS A C 1 ATOM 3233 O O . LYS A 1 405 ? -6.474 6.867 17.974 1.00 25.65 ? 405 LYS A O 1 ATOM 3234 C CB . LYS A 1 405 ? -6.706 9.200 20.206 1.00 25.96 ? 405 LYS A CB 1 ATOM 3235 C CG . LYS A 1 405 ? -5.436 9.113 21.091 1.00 25.17 ? 405 LYS A CG 1 ATOM 3236 C CD . LYS A 1 405 ? -5.744 9.048 22.560 1.00 23.17 ? 405 LYS A CD 1 ATOM 3237 C CE . LYS A 1 405 ? -4.647 8.354 23.317 1.00 24.77 ? 405 LYS A CE 1 ATOM 3238 N NZ . LYS A 1 405 ? -4.511 6.921 22.992 1.00 26.24 ? 405 LYS A NZ 1 ATOM 3239 N N . LEU A 1 406 ? -4.485 7.928 18.119 1.00 26.67 ? 406 LEU A N 1 ATOM 3240 C CA . LEU A 1 406 ? -3.726 6.739 17.812 1.00 27.49 ? 406 LEU A CA 1 ATOM 3241 C C . LEU A 1 406 ? -3.458 6.142 19.177 1.00 28.14 ? 406 LEU A C 1 ATOM 3242 O O . LEU A 1 406 ? -3.120 6.856 20.117 1.00 28.00 ? 406 LEU A O 1 ATOM 3243 C CB . LEU A 1 406 ? -2.412 7.107 17.098 1.00 27.31 ? 406 LEU A CB 1 ATOM 3244 C CG . LEU A 1 406 ? -1.479 5.930 16.793 1.00 28.02 ? 406 LEU A CG 1 ATOM 3245 C CD1 . LEU A 1 406 ? -2.024 5.061 15.632 1.00 24.78 ? 406 LEU A CD1 1 ATOM 3246 C CD2 . LEU A 1 406 ? -0.018 6.378 16.560 1.00 27.18 ? 406 LEU A CD2 1 ATOM 3247 N N . MET A 1 407 ? -3.641 4.839 19.315 1.00 28.89 ? 407 MET A N 1 ATOM 3248 C CA . MET A 1 407 ? -3.282 4.221 20.564 1.00 29.45 ? 407 MET A CA 1 ATOM 3249 C C . MET A 1 407 ? -1.744 4.297 20.732 1.00 29.61 ? 407 MET A C 1 ATOM 3250 O O . MET A 1 407 ? -0.988 4.189 19.750 1.00 28.88 ? 407 MET A O 1 ATOM 3251 C CB . MET A 1 407 ? -3.819 2.787 20.613 1.00 30.37 ? 407 MET A CB 1 ATOM 3252 C CG . MET A 1 407 ? -3.565 2.061 21.932 1.00 33.09 ? 407 MET A CG 1 ATOM 3253 S SD . MET A 1 407 ? -1.871 1.540 22.005 1.00 42.97 ? 407 MET A SD 1 ATOM 3254 C CE . MET A 1 407 ? -1.917 0.098 20.927 1.00 42.24 ? 407 MET A CE 1 ATOM 3255 N N . ASN A 1 408 ? -1.307 4.469 21.983 1.00 29.70 ? 408 ASN A N 1 ATOM 3256 C CA . ASN A 1 408 ? 0.074 4.765 22.334 1.00 29.60 ? 408 ASN A CA 1 ATOM 3257 C C . ASN A 1 408 ? 0.474 4.195 23.721 1.00 29.76 ? 408 ASN A C 1 ATOM 3258 O O . ASN A 1 408 ? -0.145 4.515 24.733 1.00 29.41 ? 408 ASN A O 1 ATOM 3259 C CB . ASN A 1 408 ? 0.221 6.287 22.304 1.00 29.69 ? 408 ASN A CB 1 ATOM 3260 C CG . ASN A 1 408 ? 1.642 6.755 22.429 1.00 29.24 ? 408 ASN A CG 1 ATOM 3261 O OD1 . ASN A 1 408 ? 2.393 6.313 23.298 1.00 28.26 ? 408 ASN A OD1 1 ATOM 3262 N ND2 . ASN A 1 408 ? 2.005 7.714 21.589 1.00 30.43 ? 408 ASN A ND2 1 ATOM 3263 N N . GLN A 1 409 ? 1.547 3.413 23.770 1.00 30.18 ? 409 GLN A N 1 ATOM 3264 C CA . GLN A 1 409 ? 1.924 2.700 24.997 1.00 30.74 ? 409 GLN A CA 1 ATOM 3265 C C . GLN A 1 409 ? 2.299 3.577 26.179 1.00 31.55 ? 409 GLN A C 1 ATOM 3266 O O . GLN A 1 409 ? 2.174 3.138 27.325 1.00 32.75 ? 409 GLN A O 1 ATOM 3267 C CB . GLN A 1 409 ? 3.070 1.720 24.746 1.00 30.55 ? 409 GLN A CB 1 ATOM 3268 C CG . GLN A 1 409 ? 2.780 0.630 23.758 1.00 30.75 ? 409 GLN A CG 1 ATOM 3269 C CD . GLN A 1 409 ? 3.975 -0.261 23.594 1.00 33.99 ? 409 GLN A CD 1 ATOM 3270 O OE1 . GLN A 1 409 ? 5.071 0.200 23.183 1.00 35.06 ? 409 GLN A OE1 1 ATOM 3271 N NE2 . GLN A 1 409 ? 3.804 -1.542 23.932 1.00 30.01 ? 409 GLN A NE2 1 ATOM 3272 N N . ASP A 1 410 ? 2.785 4.790 25.928 1.00 31.43 ? 410 ASP A N 1 ATOM 3273 C CA . ASP A 1 410 ? 3.036 5.736 27.020 1.00 31.33 ? 410 ASP A CA 1 ATOM 3274 C C . ASP A 1 410 ? 1.859 6.745 27.095 1.00 30.48 ? 410 ASP A C 1 ATOM 3275 O O . ASP A 1 410 ? 1.811 7.600 27.975 1.00 31.00 ? 410 ASP A O 1 ATOM 3276 C CB . ASP A 1 410 ? 4.396 6.467 26.867 1.00 32.15 ? 410 ASP A CB 1 ATOM 3277 C CG . ASP A 1 410 ? 5.546 5.545 26.369 1.00 34.62 ? 410 ASP A CG 1 ATOM 3278 O OD1 . ASP A 1 410 ? 6.074 4.645 27.101 1.00 39.39 ? 410 ASP A OD1 1 ATOM 3279 O OD2 . ASP A 1 410 ? 5.949 5.732 25.214 1.00 38.21 ? 410 ASP A OD2 1 ATOM 3280 N N . LYS A 1 411 ? 0.892 6.629 26.189 1.00 29.95 ? 411 LYS A N 1 ATOM 3281 C CA . LYS A 1 411 ? -0.271 7.546 26.156 1.00 29.04 ? 411 LYS A CA 1 ATOM 3282 C C . LYS A 1 411 ? -1.577 6.852 25.790 1.00 28.25 ? 411 LYS A C 1 ATOM 3283 O O . LYS A 1 411 ? -2.089 7.031 24.691 1.00 28.24 ? 411 LYS A O 1 ATOM 3284 C CB . LYS A 1 411 ? -0.030 8.687 25.181 1.00 29.33 ? 411 LYS A CB 1 ATOM 3285 C CG . LYS A 1 411 ? 1.027 9.695 25.597 1.00 27.50 ? 411 LYS A CG 1 ATOM 3286 C CD . LYS A 1 411 ? 1.100 10.760 24.518 1.00 30.07 ? 411 LYS A CD 1 ATOM 3287 C CE . LYS A 1 411 ? 2.313 11.712 24.698 1.00 29.36 ? 411 LYS A CE 1 ATOM 3288 N NZ . LYS A 1 411 ? 2.004 12.969 23.954 1.00 29.19 ? 411 LYS A NZ 1 ATOM 3289 N N . MET A 1 412 ? -2.123 6.071 26.718 1.00 26.52 ? 412 MET A N 1 ATOM 3290 C CA . MET A 1 412 ? -3.200 5.148 26.363 1.00 25.56 ? 412 MET A CA 1 ATOM 3291 C C . MET A 1 412 ? -4.631 5.703 26.303 1.00 25.09 ? 412 MET A C 1 ATOM 3292 O O . MET A 1 412 ? -5.290 5.576 25.248 1.00 24.67 ? 412 MET A O 1 ATOM 3293 C CB . MET A 1 412 ? -3.180 3.925 27.257 1.00 25.61 ? 412 MET A CB 1 ATOM 3294 C CG . MET A 1 412 ? -1.921 3.092 27.102 1.00 24.61 ? 412 MET A CG 1 ATOM 3295 S SD . MET A 1 412 ? -2.187 1.659 28.135 1.00 22.26 ? 412 MET A SD 1 ATOM 3296 C CE . MET A 1 412 ? -0.840 0.622 27.613 1.00 22.08 ? 412 MET A CE 1 ATOM 3297 N N . VAL A 1 413 ? -5.138 6.261 27.412 1.00 22.93 ? 413 VAL A N 1 ATOM 3298 C CA . VAL A 1 413 ? -6.521 6.709 27.393 1.00 22.16 ? 413 VAL A CA 1 ATOM 3299 C C . VAL A 1 413 ? -6.615 8.140 27.887 1.00 22.87 ? 413 VAL A C 1 ATOM 3300 O O . VAL A 1 413 ? -6.179 8.430 29.011 1.00 23.79 ? 413 VAL A O 1 ATOM 3301 C CB . VAL A 1 413 ? -7.453 5.774 28.213 1.00 22.07 ? 413 VAL A CB 1 ATOM 3302 C CG1 . VAL A 1 413 ? -8.864 6.371 28.367 1.00 18.94 ? 413 VAL A CG1 1 ATOM 3303 C CG2 . VAL A 1 413 ? -7.497 4.369 27.590 1.00 19.72 ? 413 VAL A CG2 1 ATOM 3304 N N . THR A 1 414 ? -7.181 9.020 27.061 1.00 21.73 ? 414 THR A N 1 ATOM 3305 C CA . THR A 1 414 ? -7.258 10.440 27.394 1.00 22.04 ? 414 THR A CA 1 ATOM 3306 C C . THR A 1 414 ? -7.973 10.684 28.731 1.00 22.24 ? 414 THR A C 1 ATOM 3307 O O . THR A 1 414 ? -8.846 9.922 29.100 1.00 21.38 ? 414 THR A O 1 ATOM 3308 C CB . THR A 1 414 ? -7.929 11.292 26.288 1.00 21.90 ? 414 THR A CB 1 ATOM 3309 O OG1 . THR A 1 414 ? -8.094 12.627 26.780 1.00 21.53 ? 414 THR A OG1 1 ATOM 3310 C CG2 . THR A 1 414 ? -9.316 10.751 25.903 1.00 21.71 ? 414 THR A CG2 1 ATOM 3311 N N . SER A 1 415 ? -7.607 11.753 29.431 1.00 22.54 ? 415 SER A N 1 ATOM 3312 C CA . SER A 1 415 ? -8.178 12.024 30.755 1.00 24.47 ? 415 SER A CA 1 ATOM 3313 C C . SER A 1 415 ? -9.627 12.442 30.735 1.00 23.43 ? 415 SER A C 1 ATOM 3314 O O . SER A 1 415 ? -10.253 12.457 31.772 1.00 24.00 ? 415 SER A O 1 ATOM 3315 C CB . SER A 1 415 ? -7.375 13.096 31.455 1.00 25.37 ? 415 SER A CB 1 ATOM 3316 O OG . SER A 1 415 ? -6.012 12.974 31.043 1.00 31.36 ? 415 SER A OG 1 ATOM 3317 N N . GLU A 1 416 ? -10.143 12.774 29.550 1.00 22.72 ? 416 GLU A N 1 ATOM 3318 C CA . GLU A 1 416 ? -11.535 13.058 29.345 1.00 22.08 ? 416 GLU A CA 1 ATOM 3319 C C . GLU A 1 416 ? -12.368 11.869 29.786 1.00 22.84 ? 416 GLU A C 1 ATOM 3320 O O . GLU A 1 416 ? -13.384 12.041 30.487 1.00 22.23 ? 416 GLU A O 1 ATOM 3321 C CB . GLU A 1 416 ? -11.768 13.392 27.890 1.00 22.74 ? 416 GLU A CB 1 ATOM 3322 C CG . GLU A 1 416 ? -10.982 14.623 27.424 1.00 22.48 ? 416 GLU A CG 1 ATOM 3323 C CD . GLU A 1 416 ? -11.383 15.858 28.195 1.00 24.53 ? 416 GLU A CD 1 ATOM 3324 O OE1 . GLU A 1 416 ? -10.510 16.463 28.867 1.00 24.96 ? 416 GLU A OE1 1 ATOM 3325 O OE2 . GLU A 1 416 ? -12.593 16.185 28.182 1.00 24.58 ? 416 GLU A OE2 1 ATOM 3326 N N . LEU A 1 417 ? -11.895 10.669 29.413 1.00 21.71 ? 417 LEU A N 1 ATOM 3327 C CA . LEU A 1 417 ? -12.496 9.397 29.788 1.00 20.73 ? 417 LEU A CA 1 ATOM 3328 C C . LEU A 1 417 ? -11.910 8.800 31.097 1.00 21.83 ? 417 LEU A C 1 ATOM 3329 O O . LEU A 1 417 ? -12.600 8.082 31.865 1.00 20.91 ? 417 LEU A O 1 ATOM 3330 C CB . LEU A 1 417 ? -12.291 8.410 28.658 1.00 19.57 ? 417 LEU A CB 1 ATOM 3331 C CG . LEU A 1 417 ? -12.995 8.686 27.340 1.00 16.20 ? 417 LEU A CG 1 ATOM 3332 C CD1 . LEU A 1 417 ? -12.330 7.850 26.257 1.00 15.41 ? 417 LEU A CD1 1 ATOM 3333 C CD2 . LEU A 1 417 ? -14.462 8.365 27.405 1.00 7.95 ? 417 LEU A CD2 1 ATOM 3334 N N . ARG A 1 418 ? -10.640 9.111 31.357 1.00 21.78 ? 418 ARG A N 1 ATOM 3335 C CA . ARG A 1 418 ? -9.948 8.518 32.475 1.00 22.14 ? 418 ARG A CA 1 ATOM 3336 C C . ARG A 1 418 ? -10.181 9.259 33.782 1.00 22.74 ? 418 ARG A C 1 ATOM 3337 O O . ARG A 1 418 ? -10.108 8.658 34.820 1.00 23.18 ? 418 ARG A O 1 ATOM 3338 C CB . ARG A 1 418 ? -8.448 8.410 32.199 1.00 21.71 ? 418 ARG A CB 1 ATOM 3339 C CG . ARG A 1 418 ? -7.801 7.270 32.986 1.00 21.86 ? 418 ARG A CG 1 ATOM 3340 C CD . ARG A 1 418 ? -6.273 7.286 32.837 1.00 23.88 ? 418 ARG A CD 1 ATOM 3341 N NE . ARG A 1 418 ? -5.660 8.385 33.580 1.00 18.78 ? 418 ARG A NE 1 ATOM 3342 C CZ . ARG A 1 418 ? -5.307 8.300 34.856 1.00 18.65 ? 418 ARG A CZ 1 ATOM 3343 N NH1 . ARG A 1 418 ? -5.542 7.193 35.508 1.00 21.80 ? 418 ARG A NH1 1 ATOM 3344 N NH2 . ARG A 1 418 ? -4.763 9.326 35.495 1.00 15.70 ? 418 ARG A NH2 1 ATOM 3345 N N . ASN A 1 419 ? -10.428 10.565 33.733 1.00 23.40 ? 419 ASN A N 1 ATOM 3346 C CA . ASN A 1 419 ? -10.636 11.328 34.952 1.00 24.79 ? 419 ASN A CA 1 ATOM 3347 C C . ASN A 1 419 ? -12.000 11.991 35.011 1.00 25.58 ? 419 ASN A C 1 ATOM 3348 O O . ASN A 1 419 ? -12.504 12.253 36.093 1.00 25.32 ? 419 ASN A O 1 ATOM 3349 C CB . ASN A 1 419 ? -9.546 12.399 35.152 1.00 24.24 ? 419 ASN A CB 1 ATOM 3350 C CG . ASN A 1 419 ? -8.259 11.837 35.711 1.00 24.56 ? 419 ASN A CG 1 ATOM 3351 O OD1 . ASN A 1 419 ? -8.238 10.950 36.560 1.00 25.23 ? 419 ASN A OD1 1 ATOM 3352 N ND2 . ASN A 1 419 ? -7.169 12.336 35.204 1.00 26.26 ? 419 ASN A ND2 1 ATOM 3353 N N . LYS A 1 420 ? -12.578 12.275 33.847 1.00 26.81 ? 420 LYS A N 1 ATOM 3354 C CA . LYS A 1 420 ? -13.783 13.102 33.775 1.00 27.83 ? 420 LYS A CA 1 ATOM 3355 C C . LYS A 1 420 ? -14.983 12.425 33.088 1.00 27.41 ? 420 LYS A C 1 ATOM 3356 O O . LYS A 1 420 ? -15.732 13.108 32.402 1.00 27.24 ? 420 LYS A O 1 ATOM 3357 C CB . LYS A 1 420 ? -13.472 14.382 33.002 1.00 27.75 ? 420 LYS A CB 1 ATOM 3358 C CG . LYS A 1 420 ? -12.533 15.356 33.655 1.00 30.91 ? 420 LYS A CG 1 ATOM 3359 C CD . LYS A 1 420 ? -12.158 16.421 32.671 1.00 35.72 ? 420 LYS A CD 1 ATOM 3360 C CE . LYS A 1 420 ? -10.820 17.037 33.004 1.00 37.53 ? 420 LYS A CE 1 ATOM 3361 N NZ . LYS A 1 420 ? -11.037 18.386 33.533 1.00 41.17 ? 420 LYS A NZ 1 ATOM 3362 N N . LEU A 1 421 ? -15.145 11.113 33.229 1.00 27.71 ? 421 LEU A N 1 ATOM 3363 C CA . LEU A 1 421 ? -16.295 10.412 32.618 1.00 29.11 ? 421 LEU A CA 1 ATOM 3364 C C . LEU A 1 421 ? -17.574 10.742 33.383 1.00 30.86 ? 421 LEU A C 1 ATOM 3365 O O . LEU A 1 421 ? -17.566 10.815 34.623 1.00 30.43 ? 421 LEU A O 1 ATOM 3366 C CB . LEU A 1 421 ? -16.094 8.884 32.578 1.00 28.54 ? 421 LEU A CB 1 ATOM 3367 C CG . LEU A 1 421 ? -17.197 7.990 31.968 1.00 27.57 ? 421 LEU A CG 1 ATOM 3368 C CD1 . LEU A 1 421 ? -17.231 8.124 30.468 1.00 27.84 ? 421 LEU A CD1 1 ATOM 3369 C CD2 . LEU A 1 421 ? -16.983 6.567 32.332 1.00 25.71 ? 421 LEU A CD2 1 ATOM 3370 N N . PHE A 1 422 ? -18.656 10.987 32.645 1.00 32.62 ? 422 PHE A N 1 ATOM 3371 C CA . PHE A 1 422 ? -19.950 11.188 33.288 1.00 34.97 ? 422 PHE A CA 1 ATOM 3372 C C . PHE A 1 422 ? -20.743 9.923 33.186 1.00 35.64 ? 422 PHE A C 1 ATOM 3373 O O . PHE A 1 422 ? -20.802 9.309 32.149 1.00 35.40 ? 422 PHE A O 1 ATOM 3374 C CB . PHE A 1 422 ? -20.756 12.357 32.700 1.00 35.04 ? 422 PHE A CB 1 ATOM 3375 C CG . PHE A 1 422 ? -21.952 12.702 33.521 1.00 35.83 ? 422 PHE A CG 1 ATOM 3376 C CD1 . PHE A 1 422 ? -21.837 13.577 34.606 1.00 38.76 ? 422 PHE A CD1 1 ATOM 3377 C CD2 . PHE A 1 422 ? -23.185 12.121 33.258 1.00 37.95 ? 422 PHE A CD2 1 ATOM 3378 C CE1 . PHE A 1 422 ? -22.956 13.891 35.408 1.00 37.56 ? 422 PHE A CE1 1 ATOM 3379 C CE2 . PHE A 1 422 ? -24.305 12.410 34.044 1.00 38.61 ? 422 PHE A CE2 1 ATOM 3380 C CZ . PHE A 1 422 ? -24.184 13.296 35.124 1.00 39.11 ? 422 PHE A CZ 1 ATOM 3381 N N . GLN A 1 423 ? -21.343 9.529 34.288 1.00 38.43 ? 423 GLN A N 1 ATOM 3382 C CA . GLN A 1 423 ? -22.165 8.322 34.329 1.00 40.82 ? 423 GLN A CA 1 ATOM 3383 C C . GLN A 1 423 ? -23.520 8.749 34.822 1.00 42.43 ? 423 GLN A C 1 ATOM 3384 O O . GLN A 1 423 ? -23.595 9.640 35.676 1.00 43.02 ? 423 GLN A O 1 ATOM 3385 C CB . GLN A 1 423 ? -21.572 7.304 35.298 1.00 40.41 ? 423 GLN A CB 1 ATOM 3386 C CG . GLN A 1 423 ? -20.205 6.798 34.866 1.00 40.62 ? 423 GLN A CG 1 ATOM 3387 C CD . GLN A 1 423 ? -20.262 5.424 34.249 1.00 38.04 ? 423 GLN A CD 1 ATOM 3388 O OE1 . GLN A 1 423 ? -20.030 4.426 34.926 1.00 40.04 ? 423 GLN A OE1 1 ATOM 3389 N NE2 . GLN A 1 423 ? -20.585 5.359 32.981 1.00 36.90 ? 423 GLN A NE2 1 ATOM 3390 N N . PRO A 1 424 ? -24.591 8.115 34.311 1.00 44.23 ? 424 PRO A N 1 ATOM 3391 C CA . PRO A 1 424 ? -25.921 8.553 34.737 1.00 45.43 ? 424 PRO A CA 1 ATOM 3392 C C . PRO A 1 424 ? -26.200 8.130 36.192 1.00 46.65 ? 424 PRO A C 1 ATOM 3393 O O . PRO A 1 424 ? -25.540 7.235 36.721 1.00 46.89 ? 424 PRO A O 1 ATOM 3394 C CB . PRO A 1 424 ? -26.865 7.871 33.727 1.00 45.56 ? 424 PRO A CB 1 ATOM 3395 C CG . PRO A 1 424 ? -25.969 7.087 32.751 1.00 44.45 ? 424 PRO A CG 1 ATOM 3396 C CD . PRO A 1 424 ? -24.660 6.913 33.451 1.00 44.37 ? 424 PRO A CD 1 ATOM 3397 N N . THR A 1 425 ? -27.159 8.804 36.822 1.00 48.25 ? 425 THR A N 1 ATOM 3398 C CA . THR A 1 425 ? -27.427 8.765 38.287 1.00 49.24 ? 425 THR A CA 1 ATOM 3399 C C . THR A 1 425 ? -26.100 8.848 39.007 1.00 49.58 ? 425 THR A C 1 ATOM 3400 O O . THR A 1 425 ? -25.885 8.163 40.012 1.00 50.39 ? 425 THR A O 1 ATOM 3401 C CB . THR A 1 425 ? -27.947 7.418 38.797 1.00 49.53 ? 425 THR A CB 1 ATOM 3402 O OG1 . THR A 1 425 ? -27.033 6.373 38.421 1.00 50.68 ? 425 THR A OG1 1 ATOM 3403 C CG2 . THR A 1 425 ? -29.374 7.154 38.276 1.00 49.79 ? 425 THR A CG2 1 ATOM 3404 N N . HIS A 1 426 ? -25.193 9.676 38.517 1.00 49.42 ? 426 HIS A N 1 ATOM 3405 C CA . HIS A 1 426 ? -24.028 9.956 39.331 1.00 49.03 ? 426 HIS A CA 1 ATOM 3406 C C . HIS A 1 426 ? -23.977 11.413 38.921 1.00 48.77 ? 426 HIS A C 1 ATOM 3407 O O . HIS A 1 426 ? -24.360 11.772 37.797 1.00 48.90 ? 426 HIS A O 1 ATOM 3408 C CB . HIS A 1 426 ? -22.731 9.179 39.200 1.00 48.88 ? 426 HIS A CB 1 ATOM 3409 C CG . HIS A 1 426 ? -22.891 7.740 39.563 1.00 49.86 ? 426 HIS A CG 1 ATOM 3410 N ND1 . HIS A 1 426 ? -23.172 7.328 40.849 1.00 51.14 ? 426 HIS A ND1 1 ATOM 3411 C CD2 . HIS A 1 426 ? -22.879 6.618 38.804 1.00 51.66 ? 426 HIS A CD2 1 ATOM 3412 C CE1 . HIS A 1 426 ? -23.299 6.011 40.871 1.00 52.33 ? 426 HIS A CE1 1 ATOM 3413 N NE2 . HIS A 1 426 ? -23.120 5.555 39.643 1.00 52.43 ? 426 HIS A NE2 1 ATOM 3414 N N . LYS A 1 427 ? -23.584 12.254 39.871 1.00 48.29 ? 427 LYS A N 1 ATOM 3415 C CA . LYS A 1 427 ? -23.744 13.700 39.744 1.00 47.06 ? 427 LYS A CA 1 ATOM 3416 C C . LYS A 1 427 ? -22.503 14.377 39.164 1.00 45.72 ? 427 LYS A C 1 ATOM 3417 O O . LYS A 1 427 ? -22.538 15.558 38.812 1.00 45.99 ? 427 LYS A O 1 ATOM 3418 C CB . LYS A 1 427 ? -24.142 14.292 41.108 1.00 47.28 ? 427 LYS A CB 1 ATOM 3419 C CG . LYS A 1 427 ? -25.668 14.308 41.354 1.00 48.60 ? 427 LYS A CG 1 ATOM 3420 C CD . LYS A 1 427 ? -26.056 14.119 42.831 1.00 50.20 ? 427 LYS A CD 1 ATOM 3421 C CE . LYS A 1 427 ? -27.587 14.228 43.016 1.00 51.76 ? 427 LYS A CE 1 ATOM 3422 N NZ . LYS A 1 427 ? -28.111 13.681 44.334 1.00 50.79 ? 427 LYS A NZ 1 ATOM 3423 N N . ILE A 1 428 ? -21.420 13.619 39.039 1.00 43.66 ? 428 ILE A N 1 ATOM 3424 C CA . ILE A 1 428 ? -20.121 14.222 38.774 1.00 42.00 ? 428 ILE A CA 1 ATOM 3425 C C . ILE A 1 428 ? -19.438 13.726 37.504 1.00 40.33 ? 428 ILE A C 1 ATOM 3426 O O . ILE A 1 428 ? -19.677 12.617 37.043 1.00 40.15 ? 428 ILE A O 1 ATOM 3427 C CB . ILE A 1 428 ? -19.168 14.043 39.991 1.00 42.78 ? 428 ILE A CB 1 ATOM 3428 C CG1 . ILE A 1 428 ? -18.650 12.600 40.078 1.00 41.80 ? 428 ILE A CG1 1 ATOM 3429 C CG2 . ILE A 1 428 ? -19.888 14.450 41.310 1.00 42.11 ? 428 ILE A CG2 1 ATOM 3430 C CD1 . ILE A 1 428 ? -17.502 12.419 41.043 1.00 41.10 ? 428 ILE A CD1 1 ATOM 3431 N N . HIS A 1 429 ? -18.592 14.575 36.931 1.00 38.48 ? 429 HIS A N 1 ATOM 3432 C CA . HIS A 1 429 ? -17.809 14.203 35.760 1.00 36.29 ? 429 HIS A CA 1 ATOM 3433 C C . HIS A 1 429 ? -16.423 13.792 36.231 1.00 35.46 ? 429 HIS A C 1 ATOM 3434 O O . HIS A 1 429 ? -15.431 14.457 35.935 1.00 35.80 ? 429 HIS A O 1 ATOM 3435 C CB . HIS A 1 429 ? -17.712 15.373 34.781 1.00 36.25 ? 429 HIS A CB 1 ATOM 3436 C CG . HIS A 1 429 ? -18.909 15.518 33.893 1.00 36.26 ? 429 HIS A CG 1 ATOM 3437 N ND1 . HIS A 1 429 ? -20.135 15.939 34.360 1.00 34.96 ? 429 HIS A ND1 1 ATOM 3438 C CD2 . HIS A 1 429 ? -19.066 15.299 32.566 1.00 35.86 ? 429 HIS A CD2 1 ATOM 3439 C CE1 . HIS A 1 429 ? -20.997 15.972 33.359 1.00 37.07 ? 429 HIS A CE1 1 ATOM 3440 N NE2 . HIS A 1 429 ? -20.374 15.589 32.260 1.00 35.67 ? 429 HIS A NE2 1 ATOM 3441 N N . GLY A 1 430 ? -16.368 12.695 36.978 1.00 33.90 ? 430 GLY A N 1 ATOM 3442 C CA . GLY A 1 430 ? -15.150 12.286 37.636 1.00 31.93 ? 430 GLY A CA 1 ATOM 3443 C C . GLY A 1 430 ? -14.826 10.808 37.596 1.00 31.25 ? 430 GLY A C 1 ATOM 3444 O O . GLY A 1 430 ? -14.054 10.330 38.420 1.00 30.96 ? 430 GLY A O 1 ATOM 3445 N N . PHE A 1 431 ? -15.389 10.072 36.647 1.00 30.03 ? 431 PHE A N 1 ATOM 3446 C CA . PHE A 1 431 ? -15.136 8.629 36.602 1.00 29.41 ? 431 PHE A CA 1 ATOM 3447 C C . PHE A 1 431 ? -13.938 8.281 35.724 1.00 28.12 ? 431 PHE A C 1 ATOM 3448 O O . PHE A 1 431 ? -13.345 9.145 35.068 1.00 27.62 ? 431 PHE A O 1 ATOM 3449 C CB . PHE A 1 431 ? -16.382 7.858 36.167 1.00 29.33 ? 431 PHE A CB 1 ATOM 3450 C CG . PHE A 1 431 ? -17.468 7.853 37.203 1.00 32.45 ? 431 PHE A CG 1 ATOM 3451 C CD1 . PHE A 1 431 ? -18.331 8.950 37.342 1.00 31.52 ? 431 PHE A CD1 1 ATOM 3452 C CD2 . PHE A 1 431 ? -17.628 6.747 38.067 1.00 33.32 ? 431 PHE A CD2 1 ATOM 3453 C CE1 . PHE A 1 431 ? -19.339 8.960 38.335 1.00 31.31 ? 431 PHE A CE1 1 ATOM 3454 C CE2 . PHE A 1 431 ? -18.638 6.749 39.039 1.00 32.91 ? 431 PHE A CE2 1 ATOM 3455 C CZ . PHE A 1 431 ? -19.495 7.857 39.168 1.00 31.99 ? 431 PHE A CZ 1 ATOM 3456 N N . ASP A 1 432 ? -13.606 6.997 35.718 1.00 26.76 ? 432 ASP A N 1 ATOM 3457 C CA . ASP A 1 432 ? -12.433 6.497 35.024 1.00 25.39 ? 432 ASP A CA 1 ATOM 3458 C C . ASP A 1 432 ? -12.830 5.292 34.205 1.00 24.43 ? 432 ASP A C 1 ATOM 3459 O O . ASP A 1 432 ? -12.974 4.163 34.717 1.00 24.52 ? 432 ASP A O 1 ATOM 3460 C CB . ASP A 1 432 ? -11.356 6.140 36.038 1.00 25.51 ? 432 ASP A CB 1 ATOM 3461 C CG . ASP A 1 432 ? -10.080 5.625 35.406 1.00 25.47 ? 432 ASP A CG 1 ATOM 3462 O OD1 . ASP A 1 432 ? -10.057 5.278 34.205 1.00 20.92 ? 432 ASP A OD1 1 ATOM 3463 O OD2 . ASP A 1 432 ? -9.087 5.546 36.172 1.00 27.86 ? 432 ASP A OD2 1 ATOM 3464 N N . LEU A 1 433 ? -12.995 5.512 32.914 1.00 22.96 ? 433 LEU A N 1 ATOM 3465 C CA . LEU A 1 433 ? -13.397 4.408 32.091 1.00 21.78 ? 433 LEU A CA 1 ATOM 3466 C C . LEU A 1 433 ? -12.392 3.244 32.145 1.00 21.66 ? 433 LEU A C 1 ATOM 3467 O O . LEU A 1 433 ? -12.824 2.091 32.215 1.00 21.72 ? 433 LEU A O 1 ATOM 3468 C CB . LEU A 1 433 ? -13.753 4.861 30.689 1.00 21.00 ? 433 LEU A CB 1 ATOM 3469 C CG . LEU A 1 433 ? -14.274 3.724 29.810 1.00 20.10 ? 433 LEU A CG 1 ATOM 3470 C CD1 . LEU A 1 433 ? -15.511 3.082 30.437 1.00 17.26 ? 433 LEU A CD1 1 ATOM 3471 C CD2 . LEU A 1 433 ? -14.546 4.277 28.430 1.00 14.51 ? 433 LEU A CD2 1 ATOM 3472 N N . ALA A 1 434 ? -11.080 3.543 32.184 1.00 21.35 ? 434 ALA A N 1 ATOM 3473 C CA . ALA A 1 434 ? -10.047 2.501 32.341 1.00 20.99 ? 434 ALA A CA 1 ATOM 3474 C C . ALA A 1 434 ? -10.212 1.664 33.618 1.00 21.24 ? 434 ALA A C 1 ATOM 3475 O O . ALA A 1 434 ? -10.382 0.443 33.558 1.00 21.72 ? 434 ALA A O 1 ATOM 3476 C CB . ALA A 1 434 ? -8.663 3.102 32.267 1.00 21.04 ? 434 ALA A CB 1 ATOM 3477 N N . ALA A 1 435 ? -10.184 2.318 34.766 1.00 21.56 ? 435 ALA A N 1 ATOM 3478 C CA . ALA A 1 435 ? -10.459 1.646 36.038 1.00 22.14 ? 435 ALA A CA 1 ATOM 3479 C C . ALA A 1 435 ? -11.708 0.799 35.926 1.00 22.34 ? 435 ALA A C 1 ATOM 3480 O O . ALA A 1 435 ? -11.675 -0.358 36.343 1.00 22.89 ? 435 ALA A O 1 ATOM 3481 C CB . ALA A 1 435 ? -10.592 2.648 37.204 1.00 22.05 ? 435 ALA A CB 1 ATOM 3482 N N . ILE A 1 436 ? -12.769 1.359 35.329 1.00 21.61 ? 436 ILE A N 1 ATOM 3483 C CA . ILE A 1 436 ? -14.018 0.653 35.075 1.00 21.03 ? 436 ILE A CA 1 ATOM 3484 C C . ILE A 1 436 ? -13.945 -0.536 34.092 1.00 22.72 ? 436 ILE A C 1 ATOM 3485 O O . ILE A 1 436 ? -14.625 -1.569 34.327 1.00 23.13 ? 436 ILE A O 1 ATOM 3486 C CB . ILE A 1 436 ? -15.146 1.608 34.622 1.00 21.59 ? 436 ILE A CB 1 ATOM 3487 C CG1 . ILE A 1 436 ? -15.638 2.456 35.810 1.00 19.52 ? 436 ILE A CG1 1 ATOM 3488 C CG2 . ILE A 1 436 ? -16.310 0.809 33.977 1.00 19.47 ? 436 ILE A CG2 1 ATOM 3489 C CD1 . ILE A 1 436 ? -16.347 3.670 35.438 1.00 20.08 ? 436 ILE A CD1 1 ATOM 3490 N N . ASN A 1 437 ? -13.168 -0.429 33.001 1.00 21.92 ? 437 ASN A N 1 ATOM 3491 C CA . ASN A 1 437 ? -12.920 -1.623 32.206 1.00 21.45 ? 437 ASN A CA 1 ATOM 3492 C C . ASN A 1 437 ? -12.297 -2.740 33.079 1.00 21.66 ? 437 ASN A C 1 ATOM 3493 O O . ASN A 1 437 ? -12.603 -3.926 32.946 1.00 20.54 ? 437 ASN A O 1 ATOM 3494 C CB . ASN A 1 437 ? -11.986 -1.306 31.033 1.00 22.35 ? 437 ASN A CB 1 ATOM 3495 C CG . ASN A 1 437 ? -12.655 -0.457 29.936 1.00 22.00 ? 437 ASN A CG 1 ATOM 3496 O OD1 . ASN A 1 437 ? -11.970 0.248 29.180 1.00 25.12 ? 437 ASN A OD1 1 ATOM 3497 N ND2 . ASN A 1 437 ? -13.960 -0.534 29.835 1.00 17.40 ? 437 ASN A ND2 1 ATOM 3498 N N . LEU A 1 438 ? -11.402 -2.342 33.975 1.00 21.91 ? 438 LEU A N 1 ATOM 3499 C CA . LEU A 1 438 ? -10.554 -3.296 34.666 1.00 21.53 ? 438 LEU A CA 1 ATOM 3500 C C . LEU A 1 438 ? -11.322 -3.978 35.777 1.00 21.64 ? 438 LEU A C 1 ATOM 3501 O O . LEU A 1 438 ? -11.312 -5.193 35.890 1.00 21.75 ? 438 LEU A O 1 ATOM 3502 C CB . LEU A 1 438 ? -9.306 -2.611 35.201 1.00 21.57 ? 438 LEU A CB 1 ATOM 3503 C CG . LEU A 1 438 ? -8.192 -2.240 34.224 1.00 21.27 ? 438 LEU A CG 1 ATOM 3504 C CD1 . LEU A 1 438 ? -7.204 -1.421 35.021 1.00 22.97 ? 438 LEU A CD1 1 ATOM 3505 C CD2 . LEU A 1 438 ? -7.516 -3.423 33.524 1.00 22.04 ? 438 LEU A CD2 1 ATOM 3506 N N . GLN A 1 439 ? -12.033 -3.194 36.567 1.00 22.34 ? 439 GLN A N 1 ATOM 3507 C CA . GLN A 1 439 ? -13.049 -3.755 37.469 1.00 22.61 ? 439 GLN A CA 1 ATOM 3508 C C . GLN A 1 439 ? -13.969 -4.688 36.696 1.00 22.05 ? 439 GLN A C 1 ATOM 3509 O O . GLN A 1 439 ? -14.180 -5.813 37.112 1.00 22.30 ? 439 GLN A O 1 ATOM 3510 C CB . GLN A 1 439 ? -13.842 -2.650 38.183 1.00 23.04 ? 439 GLN A CB 1 ATOM 3511 C CG . GLN A 1 439 ? -14.447 -3.075 39.532 1.00 22.94 ? 439 GLN A CG 1 ATOM 3512 C CD . GLN A 1 439 ? -13.421 -3.166 40.667 1.00 25.09 ? 439 GLN A CD 1 ATOM 3513 O OE1 . GLN A 1 439 ? -12.252 -3.533 40.459 1.00 27.64 ? 439 GLN A OE1 1 ATOM 3514 N NE2 . GLN A 1 439 ? -13.868 -2.878 41.881 1.00 24.65 ? 439 GLN A NE2 1 ATOM 3515 N N . ARG A 1 440 ? -14.485 -4.214 35.562 1.00 21.78 ? 440 ARG A N 1 ATOM 3516 C CA . ARG A 1 440 ? -15.362 -4.999 34.726 1.00 21.44 ? 440 ARG A CA 1 ATOM 3517 C C . ARG A 1 440 ? -14.729 -6.283 34.260 1.00 22.59 ? 440 ARG A C 1 ATOM 3518 O O . ARG A 1 440 ? -15.418 -7.282 34.180 1.00 23.84 ? 440 ARG A O 1 ATOM 3519 C CB . ARG A 1 440 ? -15.893 -4.218 33.522 1.00 20.77 ? 440 ARG A CB 1 ATOM 3520 C CG . ARG A 1 440 ? -17.125 -4.876 32.882 1.00 20.98 ? 440 ARG A CG 1 ATOM 3521 C CD . ARG A 1 440 ? -18.359 -4.867 33.829 1.00 18.60 ? 440 ARG A CD 1 ATOM 3522 N NE . ARG A 1 440 ? -18.874 -3.505 33.964 1.00 16.90 ? 440 ARG A NE 1 ATOM 3523 C CZ . ARG A 1 440 ? -19.781 -3.123 34.846 1.00 14.07 ? 440 ARG A CZ 1 ATOM 3524 N NH1 . ARG A 1 440 ? -20.282 -4.006 35.710 1.00 15.64 ? 440 ARG A NH1 1 ATOM 3525 N NH2 . ARG A 1 440 ? -20.169 -1.856 34.868 1.00 9.68 ? 440 ARG A NH2 1 ATOM 3526 N N . CYS A 1 441 ? -13.437 -6.275 33.946 1.00 23.31 ? 441 CYS A N 1 ATOM 3527 C CA . CYS A 1 441 ? -12.800 -7.472 33.475 1.00 23.72 ? 441 CYS A CA 1 ATOM 3528 C C . CYS A 1 441 ? -12.997 -8.537 34.531 1.00 23.56 ? 441 CYS A C 1 ATOM 3529 O O . CYS A 1 441 ? -13.345 -9.676 34.221 1.00 23.57 ? 441 CYS A O 1 ATOM 3530 C CB . CYS A 1 441 ? -11.317 -7.242 33.305 1.00 24.96 ? 441 CYS A CB 1 ATOM 3531 S SG . CYS A 1 441 ? -10.616 -7.356 31.661 1.00 29.22 ? 441 CYS A SG 1 ATOM 3532 N N . ARG A 1 442 ? -12.776 -8.137 35.784 1.00 23.32 ? 442 ARG A N 1 ATOM 3533 C CA . ARG A 1 442 ? -12.727 -9.035 36.927 1.00 23.28 ? 442 ARG A CA 1 ATOM 3534 C C . ARG A 1 442 ? -14.122 -9.414 37.355 1.00 23.28 ? 442 ARG A C 1 ATOM 3535 O O . ARG A 1 442 ? -14.392 -10.581 37.549 1.00 23.22 ? 442 ARG A O 1 ATOM 3536 C CB . ARG A 1 442 ? -11.945 -8.399 38.078 1.00 23.77 ? 442 ARG A CB 1 ATOM 3537 C CG . ARG A 1 442 ? -10.559 -8.009 37.671 1.00 21.77 ? 442 ARG A CG 1 ATOM 3538 C CD . ARG A 1 442 ? -9.932 -7.094 38.705 1.00 25.21 ? 442 ARG A CD 1 ATOM 3539 N NE . ARG A 1 442 ? -8.567 -6.829 38.333 1.00 25.04 ? 442 ARG A NE 1 ATOM 3540 C CZ . ARG A 1 442 ? -7.814 -5.882 38.847 1.00 27.97 ? 442 ARG A CZ 1 ATOM 3541 N NH1 . ARG A 1 442 ? -8.305 -5.087 39.775 1.00 29.26 ? 442 ARG A NH1 1 ATOM 3542 N NH2 . ARG A 1 442 ? -6.554 -5.736 38.425 1.00 29.00 ? 442 ARG A NH2 1 ATOM 3543 N N . ASP A 1 443 ? -15.012 -8.429 37.450 1.00 23.80 ? 443 ASP A N 1 ATOM 3544 C CA . ASP A 1 443 ? -16.475 -8.677 37.458 1.00 24.75 ? 443 ASP A CA 1 ATOM 3545 C C . ASP A 1 443 ? -16.899 -9.858 36.581 1.00 24.36 ? 443 ASP A C 1 ATOM 3546 O O . ASP A 1 443 ? -17.675 -10.691 37.010 1.00 24.66 ? 443 ASP A O 1 ATOM 3547 C CB . ASP A 1 443 ? -17.239 -7.406 37.015 1.00 25.09 ? 443 ASP A CB 1 ATOM 3548 C CG . ASP A 1 443 ? -18.762 -7.519 37.191 1.00 26.81 ? 443 ASP A CG 1 ATOM 3549 O OD1 . ASP A 1 443 ? -19.245 -8.479 37.863 1.00 30.67 ? 443 ASP A OD1 1 ATOM 3550 O OD2 . ASP A 1 443 ? -19.486 -6.641 36.648 1.00 25.17 ? 443 ASP A OD2 1 ATOM 3551 N N . HIS A 1 444 ? -16.386 -9.925 35.347 1.00 24.49 ? 444 HIS A N 1 ATOM 3552 C CA . HIS A 1 444 ? -16.906 -10.855 34.343 1.00 23.50 ? 444 HIS A CA 1 ATOM 3553 C C . HIS A 1 444 ? -16.188 -12.192 34.385 1.00 23.47 ? 444 HIS A C 1 ATOM 3554 O O . HIS A 1 444 ? -16.465 -13.070 33.584 1.00 24.23 ? 444 HIS A O 1 ATOM 3555 C CB . HIS A 1 444 ? -16.739 -10.270 32.956 1.00 23.71 ? 444 HIS A CB 1 ATOM 3556 C CG . HIS A 1 444 ? -17.869 -9.409 32.497 1.00 23.03 ? 444 HIS A CG 1 ATOM 3557 N ND1 . HIS A 1 444 ? -18.610 -9.693 31.365 1.00 24.03 ? 444 HIS A ND1 1 ATOM 3558 C CD2 . HIS A 1 444 ? -18.341 -8.237 32.967 1.00 22.35 ? 444 HIS A CD2 1 ATOM 3559 C CE1 . HIS A 1 444 ? -19.526 -8.759 31.192 1.00 22.13 ? 444 HIS A CE1 1 ATOM 3560 N NE2 . HIS A 1 444 ? -19.384 -7.862 32.149 1.00 23.26 ? 444 HIS A NE2 1 ATOM 3561 N N . GLY A 1 445 ? -15.263 -12.342 35.318 1.00 23.07 ? 445 GLY A N 1 ATOM 3562 C CA . GLY A 1 445 ? -14.551 -13.592 35.520 1.00 22.23 ? 445 GLY A CA 1 ATOM 3563 C C . GLY A 1 445 ? -13.576 -13.897 34.390 1.00 22.02 ? 445 GLY A C 1 ATOM 3564 O O . GLY A 1 445 ? -13.381 -15.058 34.036 1.00 21.03 ? 445 GLY A O 1 ATOM 3565 N N . MET A 1 446 ? -12.958 -12.847 33.845 1.00 21.20 ? 446 MET A N 1 ATOM 3566 C CA . MET A 1 446 ? -12.025 -13.006 32.738 1.00 20.72 ? 446 MET A CA 1 ATOM 3567 C C . MET A 1 446 ? -10.745 -13.734 33.109 1.00 20.28 ? 446 MET A C 1 ATOM 3568 O O . MET A 1 446 ? -10.012 -13.306 34.025 1.00 19.55 ? 446 MET A O 1 ATOM 3569 C CB . MET A 1 446 ? -11.657 -11.647 32.112 1.00 20.72 ? 446 MET A CB 1 ATOM 3570 C CG . MET A 1 446 ? -12.716 -11.017 31.228 1.00 20.49 ? 446 MET A CG 1 ATOM 3571 S SD . MET A 1 446 ? -13.066 -12.074 29.853 1.00 20.35 ? 446 MET A SD 1 ATOM 3572 C CE . MET A 1 446 ? -14.514 -12.984 30.393 1.00 17.68 ? 446 MET A CE 1 ATOM 3573 N N . PRO A 1 447 ? -10.455 -14.819 32.370 1.00 19.94 ? 447 PRO A N 1 ATOM 3574 C CA . PRO A 1 447 ? -9.119 -15.384 32.396 1.00 19.85 ? 447 PRO A CA 1 ATOM 3575 C C . PRO A 1 447 ? -8.085 -14.290 32.076 1.00 19.73 ? 447 PRO A C 1 ATOM 3576 O O . PRO A 1 447 ? -8.384 -13.387 31.314 1.00 19.45 ? 447 PRO A O 1 ATOM 3577 C CB . PRO A 1 447 ? -9.157 -16.451 31.293 1.00 20.32 ? 447 PRO A CB 1 ATOM 3578 C CG . PRO A 1 447 ? -10.576 -16.762 31.079 1.00 20.00 ? 447 PRO A CG 1 ATOM 3579 C CD . PRO A 1 447 ? -11.305 -15.472 31.360 1.00 20.34 ? 447 PRO A CD 1 ATOM 3580 N N . GLY A 1 448 ? -6.906 -14.362 32.696 1.00 19.44 ? 448 GLY A N 1 ATOM 3581 C CA . GLY A 1 448 ? -5.859 -13.362 32.536 1.00 19.87 ? 448 GLY A CA 1 ATOM 3582 C C . GLY A 1 448 ? -5.153 -13.417 31.191 1.00 20.59 ? 448 GLY A C 1 ATOM 3583 O O . GLY A 1 448 ? -5.480 -14.220 30.325 1.00 20.42 ? 448 GLY A O 1 ATOM 3584 N N . TYR A 1 449 ? -4.142 -12.573 31.044 1.00 21.32 ? 449 TYR A N 1 ATOM 3585 C CA . TYR A 1 449 ? -3.510 -12.328 29.761 1.00 21.52 ? 449 TYR A CA 1 ATOM 3586 C C . TYR A 1 449 ? -2.909 -13.584 29.054 1.00 21.21 ? 449 TYR A C 1 ATOM 3587 O O . TYR A 1 449 ? -3.081 -13.757 27.861 1.00 20.51 ? 449 TYR A O 1 ATOM 3588 C CB . TYR A 1 449 ? -2.500 -11.211 29.948 1.00 21.88 ? 449 TYR A CB 1 ATOM 3589 C CG . TYR A 1 449 ? -1.648 -10.875 28.728 1.00 22.17 ? 449 TYR A CG 1 ATOM 3590 C CD1 . TYR A 1 449 ? -2.163 -10.119 27.669 1.00 18.29 ? 449 TYR A CD1 1 ATOM 3591 C CD2 . TYR A 1 449 ? -0.301 -11.275 28.671 1.00 21.11 ? 449 TYR A CD2 1 ATOM 3592 C CE1 . TYR A 1 449 ? -1.353 -9.794 26.573 1.00 21.04 ? 449 TYR A CE1 1 ATOM 3593 C CE2 . TYR A 1 449 ? 0.515 -10.954 27.567 1.00 22.89 ? 449 TYR A CE2 1 ATOM 3594 C CZ . TYR A 1 449 ? -0.022 -10.213 26.536 1.00 22.70 ? 449 TYR A CZ 1 ATOM 3595 O OH . TYR A 1 449 ? 0.786 -9.895 25.465 1.00 27.20 ? 449 TYR A OH 1 ATOM 3596 N N . ASN A 1 450 ? -2.245 -14.455 29.803 1.00 21.04 ? 450 ASN A N 1 ATOM 3597 C CA . ASN A 1 450 ? -1.647 -15.686 29.248 1.00 21.27 ? 450 ASN A CA 1 ATOM 3598 C C . ASN A 1 450 ? -2.617 -16.831 28.853 1.00 21.19 ? 450 ASN A C 1 ATOM 3599 O O . ASN A 1 450 ? -2.296 -17.652 27.961 1.00 21.15 ? 450 ASN A O 1 ATOM 3600 C CB . ASN A 1 450 ? -0.535 -16.217 30.173 1.00 21.19 ? 450 ASN A CB 1 ATOM 3601 C CG . ASN A 1 450 ? 0.801 -15.444 30.029 1.00 22.99 ? 450 ASN A CG 1 ATOM 3602 O OD1 . ASN A 1 450 ? 1.182 -14.983 28.933 1.00 23.51 ? 450 ASN A OD1 1 ATOM 3603 N ND2 . ASN A 1 450 ? 1.527 -15.345 31.131 1.00 23.11 ? 450 ASN A ND2 1 ATOM 3604 N N . SER A 1 451 ? -3.764 -16.918 29.538 1.00 20.74 ? 451 SER A N 1 ATOM 3605 C CA . SER A 1 451 ? -4.831 -17.846 29.165 1.00 19.69 ? 451 SER A CA 1 ATOM 3606 C C . SER A 1 451 ? -5.299 -17.463 27.755 1.00 20.10 ? 451 SER A C 1 ATOM 3607 O O . SER A 1 451 ? -5.547 -18.317 26.880 1.00 20.66 ? 451 SER A O 1 ATOM 3608 C CB . SER A 1 451 ? -5.984 -17.690 30.142 1.00 20.32 ? 451 SER A CB 1 ATOM 3609 O OG . SER A 1 451 ? -5.647 -18.152 31.436 1.00 20.24 ? 451 SER A OG 1 ATOM 3610 N N . TRP A 1 452 ? -5.365 -16.171 27.490 1.00 19.72 ? 452 TRP A N 1 ATOM 3611 C CA . TRP A 1 452 ? -5.744 -15.735 26.142 1.00 19.91 ? 452 TRP A CA 1 ATOM 3612 C C . TRP A 1 452 ? -4.603 -15.798 25.091 1.00 20.21 ? 452 TRP A C 1 ATOM 3613 O O . TRP A 1 452 ? -4.847 -16.189 23.942 1.00 20.85 ? 452 TRP A O 1 ATOM 3614 C CB . TRP A 1 452 ? -6.435 -14.400 26.213 1.00 19.31 ? 452 TRP A CB 1 ATOM 3615 C CG . TRP A 1 452 ? -7.746 -14.475 27.015 1.00 19.85 ? 452 TRP A CG 1 ATOM 3616 C CD1 . TRP A 1 452 ? -7.995 -13.929 28.259 1.00 17.49 ? 452 TRP A CD1 1 ATOM 3617 C CD2 . TRP A 1 452 ? -8.979 -15.114 26.602 1.00 16.78 ? 452 TRP A CD2 1 ATOM 3618 N NE1 . TRP A 1 452 ? -9.310 -14.182 28.623 1.00 16.86 ? 452 TRP A NE1 1 ATOM 3619 C CE2 . TRP A 1 452 ? -9.923 -14.919 27.642 1.00 16.64 ? 452 TRP A CE2 1 ATOM 3620 C CE3 . TRP A 1 452 ? -9.375 -15.810 25.445 1.00 15.01 ? 452 TRP A CE3 1 ATOM 3621 C CZ2 . TRP A 1 452 ? -11.245 -15.421 27.569 1.00 16.37 ? 452 TRP A CZ2 1 ATOM 3622 C CZ3 . TRP A 1 452 ? -10.664 -16.328 25.375 1.00 16.97 ? 452 TRP A CZ3 1 ATOM 3623 C CH2 . TRP A 1 452 ? -11.608 -16.098 26.429 1.00 15.02 ? 452 TRP A CH2 1 ATOM 3624 N N . ARG A 1 453 ? -3.369 -15.467 25.462 1.00 20.93 ? 453 ARG A N 1 ATOM 3625 C CA . ARG A 1 453 ? -2.249 -15.712 24.559 1.00 22.52 ? 453 ARG A CA 1 ATOM 3626 C C . ARG A 1 453 ? -2.234 -17.189 24.195 1.00 23.25 ? 453 ARG A C 1 ATOM 3627 O O . ARG A 1 453 ? -2.131 -17.535 23.010 1.00 24.33 ? 453 ARG A O 1 ATOM 3628 C CB . ARG A 1 453 ? -0.906 -15.356 25.196 1.00 23.10 ? 453 ARG A CB 1 ATOM 3629 C CG . ARG A 1 453 ? -0.697 -13.889 25.477 1.00 25.35 ? 453 ARG A CG 1 ATOM 3630 C CD . ARG A 1 453 ? -0.377 -13.129 24.211 1.00 26.78 ? 453 ARG A CD 1 ATOM 3631 N NE . ARG A 1 453 ? 0.960 -13.475 23.740 1.00 29.09 ? 453 ARG A NE 1 ATOM 3632 C CZ . ARG A 1 453 ? 1.609 -12.833 22.773 1.00 26.58 ? 453 ARG A CZ 1 ATOM 3633 N NH1 . ARG A 1 453 ? 1.082 -11.775 22.139 1.00 25.01 ? 453 ARG A NH1 1 ATOM 3634 N NH2 . ARG A 1 453 ? 2.806 -13.255 22.465 1.00 27.61 ? 453 ARG A NH2 1 ATOM 3635 N N . GLY A 1 454 ? -2.362 -18.060 25.210 1.00 23.73 ? 454 GLY A N 1 ATOM 3636 C CA . GLY A 1 454 ? -2.475 -19.513 24.983 1.00 22.94 ? 454 GLY A CA 1 ATOM 3637 C C . GLY A 1 454 ? -3.580 -19.839 23.986 1.00 23.43 ? 454 GLY A C 1 ATOM 3638 O O . GLY A 1 454 ? -3.317 -20.453 22.936 1.00 23.90 ? 454 GLY A O 1 ATOM 3639 N N . PHE A 1 455 ? -4.812 -19.399 24.298 1.00 22.53 ? 455 PHE A N 1 ATOM 3640 C CA . PHE A 1 455 ? -5.984 -19.672 23.464 1.00 21.66 ? 455 PHE A CA 1 ATOM 3641 C C . PHE A 1 455 ? -5.741 -19.214 22.051 1.00 21.91 ? 455 PHE A C 1 ATOM 3642 O O . PHE A 1 455 ? -6.232 -19.802 21.142 1.00 21.32 ? 455 PHE A O 1 ATOM 3643 C CB . PHE A 1 455 ? -7.232 -18.969 24.050 1.00 21.54 ? 455 PHE A CB 1 ATOM 3644 C CG . PHE A 1 455 ? -8.452 -18.987 23.167 1.00 16.64 ? 455 PHE A CG 1 ATOM 3645 C CD1 . PHE A 1 455 ? -9.422 -19.950 23.343 1.00 17.33 ? 455 PHE A CD1 1 ATOM 3646 C CD2 . PHE A 1 455 ? -8.657 -18.004 22.212 1.00 16.58 ? 455 PHE A CD2 1 ATOM 3647 C CE1 . PHE A 1 455 ? -10.577 -19.968 22.582 1.00 17.45 ? 455 PHE A CE1 1 ATOM 3648 C CE2 . PHE A 1 455 ? -9.812 -18.002 21.410 1.00 15.97 ? 455 PHE A CE2 1 ATOM 3649 C CZ . PHE A 1 455 ? -10.767 -18.988 21.592 1.00 19.67 ? 455 PHE A CZ 1 ATOM 3650 N N . CYS A 1 456 ? -5.001 -18.136 21.873 1.00 23.80 ? 456 CYS A N 1 ATOM 3651 C CA . CYS A 1 456 ? -4.639 -17.678 20.523 1.00 25.99 ? 456 CYS A CA 1 ATOM 3652 C C . CYS A 1 456 ? -3.375 -18.311 19.934 1.00 27.36 ? 456 CYS A C 1 ATOM 3653 O O . CYS A 1 456 ? -2.967 -17.942 18.817 1.00 28.15 ? 456 CYS A O 1 ATOM 3654 C CB . CYS A 1 456 ? -4.469 -16.158 20.510 1.00 25.95 ? 456 CYS A CB 1 ATOM 3655 S SG . CYS A 1 456 ? -6.046 -15.384 20.602 1.00 27.26 ? 456 CYS A SG 1 ATOM 3656 N N . GLY A 1 457 ? -2.745 -19.231 20.659 1.00 27.30 ? 457 GLY A N 1 ATOM 3657 C CA . GLY A 1 457 ? -1.594 -19.933 20.094 1.00 29.16 ? 457 GLY A CA 1 ATOM 3658 C C . GLY A 1 457 ? -0.341 -19.080 20.101 1.00 29.63 ? 457 GLY A C 1 ATOM 3659 O O . GLY A 1 457 ? 0.519 -19.218 19.238 1.00 30.63 ? 457 GLY A O 1 ATOM 3660 N N . LEU A 1 458 ? -0.271 -18.177 21.071 1.00 29.88 ? 458 LEU A N 1 ATOM 3661 C CA . LEU A 1 458 ? 0.771 -17.191 21.165 1.00 29.59 ? 458 LEU A CA 1 ATOM 3662 C C . LEU A 1 458 ? 1.534 -17.489 22.414 1.00 30.36 ? 458 LEU A C 1 ATOM 3663 O O . LEU A 1 458 ? 1.003 -18.130 23.337 1.00 29.61 ? 458 LEU A O 1 ATOM 3664 C CB . LEU A 1 458 ? 0.178 -15.778 21.219 1.00 28.53 ? 458 LEU A CB 1 ATOM 3665 C CG . LEU A 1 458 ? -0.493 -15.328 19.910 1.00 28.24 ? 458 LEU A CG 1 ATOM 3666 C CD1 . LEU A 1 458 ? -1.255 -14.026 20.121 1.00 27.19 ? 458 LEU A CD1 1 ATOM 3667 C CD2 . LEU A 1 458 ? 0.458 -15.220 18.692 1.00 23.85 ? 458 LEU A CD2 1 ATOM 3668 N N . SER A 1 459 ? 2.784 -17.020 22.441 1.00 31.42 ? 459 SER A N 1 ATOM 3669 C CA . SER A 1 459 ? 3.672 -17.225 23.589 1.00 32.40 ? 459 SER A CA 1 ATOM 3670 C C . SER A 1 459 ? 3.140 -16.586 24.866 1.00 32.25 ? 459 SER A C 1 ATOM 3671 O O . SER A 1 459 ? 2.370 -15.620 24.856 1.00 32.56 ? 459 SER A O 1 ATOM 3672 C CB . SER A 1 459 ? 5.045 -16.651 23.299 1.00 32.64 ? 459 SER A CB 1 ATOM 3673 O OG . SER A 1 459 ? 4.897 -15.275 22.973 1.00 35.31 ? 459 SER A OG 1 ATOM 3674 N N . GLN A 1 460 ? 3.589 -17.143 25.968 1.00 32.60 ? 460 GLN A N 1 ATOM 3675 C CA . GLN A 1 460 ? 3.161 -16.734 27.259 1.00 33.29 ? 460 GLN A CA 1 ATOM 3676 C C . GLN A 1 460 ? 4.434 -16.338 28.003 1.00 34.02 ? 460 GLN A C 1 ATOM 3677 O O . GLN A 1 460 ? 5.217 -17.194 28.414 1.00 34.09 ? 460 GLN A O 1 ATOM 3678 C CB . GLN A 1 460 ? 2.390 -17.876 27.945 1.00 33.31 ? 460 GLN A CB 1 ATOM 3679 C CG . GLN A 1 460 ? 1.207 -18.382 27.125 1.00 31.80 ? 460 GLN A CG 1 ATOM 3680 C CD . GLN A 1 460 ? 0.527 -19.587 27.738 1.00 32.81 ? 460 GLN A CD 1 ATOM 3681 O OE1 . GLN A 1 460 ? 0.202 -19.583 28.921 1.00 32.38 ? 460 GLN A OE1 1 ATOM 3682 N NE2 . GLN A 1 460 ? 0.267 -20.613 26.921 1.00 30.86 ? 460 GLN A NE2 1 ATOM 3683 N N . PRO A 1 461 ? 4.675 -15.020 28.115 1.00 34.69 ? 461 PRO A N 1 ATOM 3684 C CA . PRO A 1 461 ? 5.821 -14.515 28.857 1.00 35.41 ? 461 PRO A CA 1 ATOM 3685 C C . PRO A 1 461 ? 5.620 -14.763 30.345 1.00 36.00 ? 461 PRO A C 1 ATOM 3686 O O . PRO A 1 461 ? 4.522 -14.521 30.868 1.00 35.79 ? 461 PRO A O 1 ATOM 3687 C CB . PRO A 1 461 ? 5.801 -13.011 28.550 1.00 35.58 ? 461 PRO A CB 1 ATOM 3688 C CG . PRO A 1 461 ? 4.412 -12.716 28.138 1.00 35.70 ? 461 PRO A CG 1 ATOM 3689 C CD . PRO A 1 461 ? 3.922 -13.941 27.450 1.00 34.51 ? 461 PRO A CD 1 ATOM 3690 N N . LYS A 1 462 ? 6.650 -15.280 31.008 1.00 36.49 ? 462 LYS A N 1 ATOM 3691 C CA . LYS A 1 462 ? 6.556 -15.602 32.431 1.00 37.65 ? 462 LYS A CA 1 ATOM 3692 C C . LYS A 1 462 ? 7.358 -14.614 33.265 1.00 38.32 ? 462 LYS A C 1 ATOM 3693 O O . LYS A 1 462 ? 7.105 -14.455 34.463 1.00 38.61 ? 462 LYS A O 1 ATOM 3694 C CB . LYS A 1 462 ? 7.006 -17.044 32.704 1.00 37.38 ? 462 LYS A CB 1 ATOM 3695 C CG . LYS A 1 462 ? 6.169 -18.098 31.995 1.00 37.98 ? 462 LYS A CG 1 ATOM 3696 C CD . LYS A 1 462 ? 4.790 -18.156 32.593 1.00 39.04 ? 462 LYS A CD 1 ATOM 3697 C CE . LYS A 1 462 ? 3.789 -18.797 31.643 1.00 39.19 ? 462 LYS A CE 1 ATOM 3698 N NZ . LYS A 1 462 ? 2.559 -19.072 32.450 1.00 38.39 ? 462 LYS A NZ 1 ATOM 3699 N N . THR A 1 463 ? 8.301 -13.936 32.605 1.00 38.79 ? 463 THR A N 1 ATOM 3700 C CA . THR A 1 463 ? 9.213 -12.994 33.248 1.00 38.99 ? 463 THR A CA 1 ATOM 3701 C C . THR A 1 463 ? 9.205 -11.623 32.589 1.00 39.48 ? 463 THR A C 1 ATOM 3702 O O . THR A 1 463 ? 8.820 -11.498 31.424 1.00 39.92 ? 463 THR A O 1 ATOM 3703 C CB . THR A 1 463 ? 10.651 -13.513 33.163 1.00 39.02 ? 463 THR A CB 1 ATOM 3704 O OG1 . THR A 1 463 ? 11.006 -13.662 31.779 1.00 37.67 ? 463 THR A OG1 1 ATOM 3705 C CG2 . THR A 1 463 ? 10.782 -14.853 33.919 1.00 38.21 ? 463 THR A CG2 1 ATOM 3706 N N . LEU A 1 464 ? 9.666 -10.603 33.325 1.00 39.76 ? 464 LEU A N 1 ATOM 3707 C CA . LEU A 1 464 ? 9.800 -9.250 32.779 1.00 39.66 ? 464 LEU A CA 1 ATOM 3708 C C . LEU A 1 464 ? 10.365 -9.289 31.376 1.00 39.48 ? 464 LEU A C 1 ATOM 3709 O O . LEU A 1 464 ? 9.772 -8.741 30.430 1.00 38.67 ? 464 LEU A O 1 ATOM 3710 C CB . LEU A 1 464 ? 10.677 -8.362 33.672 1.00 40.09 ? 464 LEU A CB 1 ATOM 3711 C CG . LEU A 1 464 ? 11.126 -6.985 33.141 1.00 40.09 ? 464 LEU A CG 1 ATOM 3712 C CD1 . LEU A 1 464 ? 9.934 -6.115 32.781 1.00 39.74 ? 464 LEU A CD1 1 ATOM 3713 C CD2 . LEU A 1 464 ? 11.997 -6.277 34.162 1.00 37.90 ? 464 LEU A CD2 1 ATOM 3714 N N . LYS A 1 465 ? 11.503 -9.967 31.255 1.00 39.89 ? 465 LYS A N 1 ATOM 3715 C CA . LYS A 1 465 ? 12.240 -10.062 30.003 1.00 39.70 ? 465 LYS A CA 1 ATOM 3716 C C . LYS A 1 465 ? 11.336 -10.636 28.915 1.00 39.40 ? 465 LYS A C 1 ATOM 3717 O O . LYS A 1 465 ? 11.280 -10.107 27.794 1.00 38.84 ? 465 LYS A O 1 ATOM 3718 C CB . LYS A 1 465 ? 13.501 -10.914 30.216 1.00 40.77 ? 465 LYS A CB 1 ATOM 3719 C CG . LYS A 1 465 ? 14.491 -10.920 29.041 1.00 42.23 ? 465 LYS A CG 1 ATOM 3720 C CD . LYS A 1 465 ? 15.114 -9.551 28.821 1.00 45.36 ? 465 LYS A CD 1 ATOM 3721 C CE . LYS A 1 465 ? 16.053 -9.589 27.636 1.00 48.29 ? 465 LYS A CE 1 ATOM 3722 N NZ . LYS A 1 465 ? 15.298 -9.965 26.394 1.00 49.96 ? 465 LYS A NZ 1 ATOM 3723 N N . GLY A 1 466 ? 10.605 -11.701 29.260 1.00 39.30 ? 466 GLY A N 1 ATOM 3724 C CA . GLY A 1 466 ? 9.524 -12.207 28.410 1.00 38.13 ? 466 GLY A CA 1 ATOM 3725 C C . GLY A 1 466 ? 8.593 -11.090 27.963 1.00 37.42 ? 466 GLY A C 1 ATOM 3726 O O . GLY A 1 466 ? 8.410 -10.869 26.763 1.00 37.63 ? 466 GLY A O 1 ATOM 3727 N N . LEU A 1 467 ? 8.033 -10.361 28.929 1.00 36.59 ? 467 LEU A N 1 ATOM 3728 C CA . LEU A 1 467 ? 7.035 -9.311 28.641 1.00 35.89 ? 467 LEU A CA 1 ATOM 3729 C C . LEU A 1 467 ? 7.595 -8.163 27.783 1.00 36.21 ? 467 LEU A C 1 ATOM 3730 O O . LEU A 1 467 ? 6.950 -7.739 26.823 1.00 36.01 ? 467 LEU A O 1 ATOM 3731 C CB . LEU A 1 467 ? 6.423 -8.798 29.951 1.00 35.47 ? 467 LEU A CB 1 ATOM 3732 C CG . LEU A 1 467 ? 5.085 -8.060 30.050 1.00 34.32 ? 467 LEU A CG 1 ATOM 3733 C CD1 . LEU A 1 467 ? 3.915 -8.795 29.403 1.00 29.78 ? 467 LEU A CD1 1 ATOM 3734 C CD2 . LEU A 1 467 ? 4.798 -7.809 31.522 1.00 33.07 ? 467 LEU A CD2 1 ATOM 3735 N N . GLN A 1 468 ? 8.795 -7.676 28.112 1.00 36.90 ? 468 GLN A N 1 ATOM 3736 C CA . GLN A 1 468 ? 9.450 -6.626 27.318 1.00 37.47 ? 468 GLN A CA 1 ATOM 3737 C C . GLN A 1 468 ? 9.473 -6.999 25.850 1.00 37.58 ? 468 GLN A C 1 ATOM 3738 O O . GLN A 1 468 ? 9.251 -6.142 24.972 1.00 38.21 ? 468 GLN A O 1 ATOM 3739 C CB . GLN A 1 468 ? 10.905 -6.404 27.736 1.00 38.16 ? 468 GLN A CB 1 ATOM 3740 C CG . GLN A 1 468 ? 11.215 -6.062 29.188 1.00 39.69 ? 468 GLN A CG 1 ATOM 3741 C CD . GLN A 1 468 ? 12.722 -5.913 29.421 1.00 42.55 ? 468 GLN A CD 1 ATOM 3742 O OE1 . GLN A 1 468 ? 13.161 -5.341 30.427 1.00 44.87 ? 468 GLN A OE1 1 ATOM 3743 N NE2 . GLN A 1 468 ? 13.519 -6.408 28.478 1.00 42.74 ? 468 GLN A NE2 1 ATOM 3744 N N . THR A 1 469 ? 9.728 -8.279 25.587 1.00 37.37 ? 469 THR A N 1 ATOM 3745 C CA . THR A 1 469 ? 9.912 -8.781 24.229 1.00 37.05 ? 469 THR A CA 1 ATOM 3746 C C . THR A 1 469 ? 8.631 -8.804 23.444 1.00 36.47 ? 469 THR A C 1 ATOM 3747 O O . THR A 1 469 ? 8.627 -8.415 22.270 1.00 37.43 ? 469 THR A O 1 ATOM 3748 C CB . THR A 1 469 ? 10.512 -10.192 24.202 1.00 37.51 ? 469 THR A CB 1 ATOM 3749 O OG1 . THR A 1 469 ? 11.469 -10.327 25.261 1.00 38.98 ? 469 THR A OG1 1 ATOM 3750 C CG2 . THR A 1 469 ? 11.194 -10.455 22.842 1.00 38.52 ? 469 THR A CG2 1 ATOM 3751 N N . VAL A 1 470 ? 7.559 -9.298 24.078 1.00 35.68 ? 470 VAL A N 1 ATOM 3752 C CA . VAL A 1 470 ? 6.206 -9.314 23.504 1.00 33.47 ? 470 VAL A CA 1 ATOM 3753 C C . VAL A 1 470 ? 5.695 -7.883 23.356 1.00 32.76 ? 470 VAL A C 1 ATOM 3754 O O . VAL A 1 470 ? 5.348 -7.474 22.258 1.00 32.04 ? 470 VAL A O 1 ATOM 3755 C CB . VAL A 1 470 ? 5.236 -10.144 24.410 1.00 34.16 ? 470 VAL A CB 1 ATOM 3756 C CG1 . VAL A 1 470 ? 3.769 -10.001 23.972 1.00 32.69 ? 470 VAL A CG1 1 ATOM 3757 C CG2 . VAL A 1 470 ? 5.656 -11.610 24.461 1.00 34.49 ? 470 VAL A CG2 1 ATOM 3758 N N . LEU A 1 471 ? 5.690 -7.119 24.456 1.00 31.88 ? 471 LEU A N 1 ATOM 3759 C CA . LEU A 1 471 ? 5.156 -5.754 24.463 1.00 32.18 ? 471 LEU A CA 1 ATOM 3760 C C . LEU A 1 471 ? 6.035 -4.784 23.700 1.00 32.51 ? 471 LEU A C 1 ATOM 3761 O O . LEU A 1 471 ? 5.673 -3.613 23.513 1.00 31.66 ? 471 LEU A O 1 ATOM 3762 C CB . LEU A 1 471 ? 4.974 -5.233 25.903 1.00 32.02 ? 471 LEU A CB 1 ATOM 3763 C CG . LEU A 1 471 ? 3.942 -6.010 26.737 1.00 31.12 ? 471 LEU A CG 1 ATOM 3764 C CD1 . LEU A 1 471 ? 3.540 -5.241 27.957 1.00 30.36 ? 471 LEU A CD1 1 ATOM 3765 C CD2 . LEU A 1 471 ? 2.745 -6.328 25.920 1.00 27.94 ? 471 LEU A CD2 1 ATOM 3766 N N . LYS A 1 472 ? 7.208 -5.287 23.290 1.00 33.53 ? 472 LYS A N 1 ATOM 3767 C CA . LYS A 1 472 ? 8.301 -4.492 22.683 1.00 33.83 ? 472 LYS A CA 1 ATOM 3768 C C . LYS A 1 472 ? 8.511 -3.133 23.361 1.00 33.44 ? 472 LYS A C 1 ATOM 3769 O O . LYS A 1 472 ? 8.719 -2.132 22.706 1.00 33.19 ? 472 LYS A O 1 ATOM 3770 C CB . LYS A 1 472 ? 8.104 -4.370 21.185 1.00 33.73 ? 472 LYS A CB 1 ATOM 3771 C CG . LYS A 1 472 ? 8.059 -5.751 20.503 1.00 37.01 ? 472 LYS A CG 1 ATOM 3772 C CD . LYS A 1 472 ? 7.294 -5.699 19.158 1.00 40.92 ? 472 LYS A CD 1 ATOM 3773 C CE . LYS A 1 472 ? 7.700 -6.842 18.232 1.00 43.53 ? 472 LYS A CE 1 ATOM 3774 N NZ . LYS A 1 472 ? 7.887 -8.147 18.981 1.00 46.04 ? 472 LYS A NZ 1 ATOM 3775 N N . ASN A 1 473 ? 8.444 -3.130 24.690 1.00 33.20 ? 473 ASN A N 1 ATOM 3776 C CA . ASN A 1 473 ? 8.592 -1.916 25.482 1.00 33.18 ? 473 ASN A CA 1 ATOM 3777 C C . ASN A 1 473 ? 9.157 -2.312 26.831 1.00 33.46 ? 473 ASN A C 1 ATOM 3778 O O . ASN A 1 473 ? 8.574 -3.139 27.528 1.00 34.12 ? 473 ASN A O 1 ATOM 3779 C CB . ASN A 1 473 ? 7.236 -1.219 25.641 1.00 33.11 ? 473 ASN A CB 1 ATOM 3780 C CG . ASN A 1 473 ? 7.336 0.119 26.348 1.00 32.22 ? 473 ASN A CG 1 ATOM 3781 O OD1 . ASN A 1 473 ? 8.118 0.282 27.281 1.00 31.36 ? 473 ASN A OD1 1 ATOM 3782 N ND2 . ASN A 1 473 ? 6.537 1.092 25.897 1.00 30.76 ? 473 ASN A ND2 1 ATOM 3783 N N . LYS A 1 474 ? 10.312 -1.750 27.183 1.00 34.26 ? 474 LYS A N 1 ATOM 3784 C CA . LYS A 1 474 ? 11.022 -2.110 28.420 1.00 34.63 ? 474 LYS A CA 1 ATOM 3785 C C . LYS A 1 474 ? 10.354 -1.491 29.638 1.00 34.81 ? 474 LYS A C 1 ATOM 3786 O O . LYS A 1 474 ? 10.293 -2.101 30.690 1.00 35.73 ? 474 LYS A O 1 ATOM 3787 C CB . LYS A 1 474 ? 12.529 -1.761 28.342 1.00 34.86 ? 474 LYS A CB 1 ATOM 3788 C CG . LYS A 1 474 ? 12.934 -0.339 27.735 1.00 36.27 ? 474 LYS A CG 1 ATOM 3789 C CD . LYS A 1 474 ? 13.463 -0.313 26.232 1.00 31.46 ? 474 LYS A CD 1 ATOM 3790 C CE . LYS A 1 474 ? 12.344 0.012 25.309 1.00 28.08 ? 474 LYS A CE 1 ATOM 3791 N NZ . LYS A 1 474 ? 11.534 1.061 26.052 1.00 30.46 ? 474 LYS A NZ 1 ATOM 3792 N N . ILE A 1 475 ? 9.800 -0.298 29.461 1.00 34.63 ? 475 ILE A N 1 ATOM 3793 C CA . ILE A 1 475 ? 9.261 0.519 30.541 1.00 34.56 ? 475 ILE A CA 1 ATOM 3794 C C . ILE A 1 475 ? 7.888 0.021 31.040 1.00 33.77 ? 475 ILE A C 1 ATOM 3795 O O . ILE A 1 475 ? 7.671 -0.177 32.237 1.00 32.91 ? 475 ILE A O 1 ATOM 3796 C CB . ILE A 1 475 ? 9.073 1.995 30.062 1.00 34.84 ? 475 ILE A CB 1 ATOM 3797 C CG1 . ILE A 1 475 ? 10.076 2.353 28.946 1.00 36.27 ? 475 ILE A CG1 1 ATOM 3798 C CG2 . ILE A 1 475 ? 9.106 2.928 31.264 1.00 35.86 ? 475 ILE A CG2 1 ATOM 3799 C CD1 . ILE A 1 475 ? 10.169 3.863 28.589 1.00 39.59 ? 475 ILE A CD1 1 ATOM 3800 N N . LEU A 1 476 ? 6.970 -0.123 30.088 1.00 33.04 ? 476 LEU A N 1 ATOM 3801 C CA . LEU A 1 476 ? 5.616 -0.586 30.320 1.00 32.80 ? 476 LEU A CA 1 ATOM 3802 C C . LEU A 1 476 ? 5.637 -1.965 30.964 1.00 32.86 ? 476 LEU A C 1 ATOM 3803 O O . LEU A 1 476 ? 5.026 -2.176 32.012 1.00 32.86 ? 476 LEU A O 1 ATOM 3804 C CB . LEU A 1 476 ? 4.879 -0.609 28.969 1.00 33.07 ? 476 LEU A CB 1 ATOM 3805 C CG . LEU A 1 476 ? 3.444 -1.104 28.880 1.00 31.57 ? 476 LEU A CG 1 ATOM 3806 C CD1 . LEU A 1 476 ? 2.526 -0.332 29.820 1.00 28.67 ? 476 LEU A CD1 1 ATOM 3807 C CD2 . LEU A 1 476 ? 3.008 -0.967 27.470 1.00 29.52 ? 476 LEU A CD2 1 ATOM 3808 N N . ALA A 1 477 ? 6.395 -2.887 30.381 1.00 32.96 ? 477 ALA A N 1 ATOM 3809 C CA . ALA A 1 477 ? 6.515 -4.228 30.962 1.00 33.57 ? 477 ALA A CA 1 ATOM 3810 C C . ALA A 1 477 ? 6.904 -4.213 32.442 1.00 33.70 ? 477 ALA A C 1 ATOM 3811 O O . ALA A 1 477 ? 6.373 -4.973 33.246 1.00 32.98 ? 477 ALA A O 1 ATOM 3812 C CB . ALA A 1 477 ? 7.488 -5.076 30.160 1.00 33.50 ? 477 ALA A CB 1 ATOM 3813 N N . LYS A 1 478 ? 7.838 -3.327 32.779 1.00 34.85 ? 478 LYS A N 1 ATOM 3814 C CA . LYS A 1 478 ? 8.357 -3.206 34.124 1.00 35.24 ? 478 LYS A CA 1 ATOM 3815 C C . LYS A 1 478 ? 7.268 -2.729 35.071 1.00 35.19 ? 478 LYS A C 1 ATOM 3816 O O . LYS A 1 478 ? 7.088 -3.310 36.173 1.00 35.90 ? 478 LYS A O 1 ATOM 3817 C CB . LYS A 1 478 ? 9.539 -2.233 34.131 1.00 36.11 ? 478 LYS A CB 1 ATOM 3818 C CG . LYS A 1 478 ? 10.193 -1.999 35.482 1.00 36.68 ? 478 LYS A CG 1 ATOM 3819 C CD . LYS A 1 478 ? 11.312 -0.934 35.311 1.00 44.02 ? 478 LYS A CD 1 ATOM 3820 C CE . LYS A 1 478 ? 12.300 -1.231 34.137 1.00 43.47 ? 478 LYS A CE 1 ATOM 3821 N NZ . LYS A 1 478 ? 13.232 -2.383 34.407 1.00 43.84 ? 478 LYS A NZ 1 ATOM 3822 N N . LYS A 1 479 ? 6.537 -1.690 34.652 1.00 33.76 ? 479 LYS A N 1 ATOM 3823 C CA . LYS A 1 479 ? 5.405 -1.209 35.446 1.00 33.25 ? 479 LYS A CA 1 ATOM 3824 C C . LYS A 1 479 ? 4.322 -2.269 35.567 1.00 32.03 ? 479 LYS A C 1 ATOM 3825 O O . LYS A 1 479 ? 3.702 -2.401 36.609 1.00 32.63 ? 479 LYS A O 1 ATOM 3826 C CB . LYS A 1 479 ? 4.819 0.076 34.863 1.00 33.86 ? 479 LYS A CB 1 ATOM 3827 C CG . LYS A 1 479 ? 5.829 1.190 34.634 1.00 35.03 ? 479 LYS A CG 1 ATOM 3828 C CD . LYS A 1 479 ? 5.247 2.209 33.691 1.00 37.51 ? 479 LYS A CD 1 ATOM 3829 C CE . LYS A 1 479 ? 6.085 3.473 33.645 1.00 40.61 ? 479 LYS A CE 1 ATOM 3830 N NZ . LYS A 1 479 ? 5.559 4.453 32.641 1.00 41.69 ? 479 LYS A NZ 1 ATOM 3831 N N . LEU A 1 480 ? 4.094 -3.021 34.501 1.00 31.34 ? 480 LEU A N 1 ATOM 3832 C CA . LEU A 1 480 ? 3.114 -4.095 34.522 1.00 31.63 ? 480 LEU A CA 1 ATOM 3833 C C . LEU A 1 480 ? 3.534 -5.190 35.486 1.00 32.27 ? 480 LEU A C 1 ATOM 3834 O O . LEU A 1 480 ? 2.720 -5.683 36.286 1.00 31.47 ? 480 LEU A O 1 ATOM 3835 C CB . LEU A 1 480 ? 2.885 -4.646 33.116 1.00 31.33 ? 480 LEU A CB 1 ATOM 3836 C CG . LEU A 1 480 ? 1.945 -3.760 32.291 1.00 31.47 ? 480 LEU A CG 1 ATOM 3837 C CD1 . LEU A 1 480 ? 1.996 -4.096 30.815 1.00 31.61 ? 480 LEU A CD1 1 ATOM 3838 C CD2 . LEU A 1 480 ? 0.498 -3.810 32.827 1.00 30.68 ? 480 LEU A CD2 1 ATOM 3839 N N . MET A 1 481 ? 4.823 -5.532 35.437 1.00 32.98 ? 481 MET A N 1 ATOM 3840 C CA . MET A 1 481 ? 5.415 -6.463 36.402 1.00 33.25 ? 481 MET A CA 1 ATOM 3841 C C . MET A 1 481 ? 5.321 -6.005 37.838 1.00 33.75 ? 481 MET A C 1 ATOM 3842 O O . MET A 1 481 ? 4.864 -6.773 38.688 1.00 34.57 ? 481 MET A O 1 ATOM 3843 C CB . MET A 1 481 ? 6.843 -6.820 36.027 1.00 32.77 ? 481 MET A CB 1 ATOM 3844 C CG . MET A 1 481 ? 6.884 -7.759 34.844 1.00 33.34 ? 481 MET A CG 1 ATOM 3845 S SD . MET A 1 481 ? 5.753 -9.175 35.043 1.00 34.76 ? 481 MET A SD 1 ATOM 3846 C CE . MET A 1 481 ? 6.817 -10.291 35.982 1.00 31.11 ? 481 MET A CE 1 ATOM 3847 N N . ASP A 1 482 ? 5.706 -4.757 38.119 1.00 34.20 ? 482 ASP A N 1 ATOM 3848 C CA . ASP A 1 482 ? 5.571 -4.229 39.480 1.00 34.33 ? 482 ASP A CA 1 ATOM 3849 C C . ASP A 1 482 ? 4.137 -4.295 39.968 1.00 33.81 ? 482 ASP A C 1 ATOM 3850 O O . ASP A 1 482 ? 3.888 -4.645 41.104 1.00 34.56 ? 482 ASP A O 1 ATOM 3851 C CB . ASP A 1 482 ? 6.082 -2.795 39.590 1.00 35.22 ? 482 ASP A CB 1 ATOM 3852 C CG . ASP A 1 482 ? 7.541 -2.660 39.216 1.00 37.06 ? 482 ASP A CG 1 ATOM 3853 O OD1 . ASP A 1 482 ? 8.165 -3.681 38.841 1.00 39.50 ? 482 ASP A OD1 1 ATOM 3854 O OD2 . ASP A 1 482 ? 8.065 -1.523 39.292 1.00 39.22 ? 482 ASP A OD2 1 ATOM 3855 N N . LEU A 1 483 ? 3.179 -3.974 39.110 1.00 33.60 ? 483 LEU A N 1 ATOM 3856 C CA . LEU A 1 483 ? 1.761 -3.993 39.528 1.00 32.25 ? 483 LEU A CA 1 ATOM 3857 C C . LEU A 1 483 ? 1.155 -5.395 39.678 1.00 31.22 ? 483 LEU A C 1 ATOM 3858 O O . LEU A 1 483 ? 0.371 -5.639 40.592 1.00 30.30 ? 483 LEU A O 1 ATOM 3859 C CB . LEU A 1 483 ? 0.903 -3.127 38.589 1.00 32.27 ? 483 LEU A CB 1 ATOM 3860 C CG . LEU A 1 483 ? 0.940 -1.621 38.871 1.00 33.40 ? 483 LEU A CG 1 ATOM 3861 C CD1 . LEU A 1 483 ? 0.233 -0.878 37.770 1.00 34.83 ? 483 LEU A CD1 1 ATOM 3862 C CD2 . LEU A 1 483 ? 0.314 -1.275 40.211 1.00 32.58 ? 483 LEU A CD2 1 ATOM 3863 N N . TYR A 1 484 ? 1.534 -6.303 38.785 1.00 30.69 ? 484 TYR A N 1 ATOM 3864 C CA . TYR A 1 484 ? 0.900 -7.616 38.683 1.00 30.84 ? 484 TYR A CA 1 ATOM 3865 C C . TYR A 1 484 ? 1.735 -8.816 39.138 1.00 31.20 ? 484 TYR A C 1 ATOM 3866 O O . TYR A 1 484 ? 1.169 -9.867 39.440 1.00 32.17 ? 484 TYR A O 1 ATOM 3867 C CB . TYR A 1 484 ? 0.455 -7.863 37.244 1.00 30.44 ? 484 TYR A CB 1 ATOM 3868 C CG . TYR A 1 484 ? -0.766 -7.068 36.793 1.00 29.31 ? 484 TYR A CG 1 ATOM 3869 C CD1 . TYR A 1 484 ? -2.070 -7.559 36.990 1.00 29.45 ? 484 TYR A CD1 1 ATOM 3870 C CD2 . TYR A 1 484 ? -0.614 -5.848 36.141 1.00 26.29 ? 484 TYR A CD2 1 ATOM 3871 C CE1 . TYR A 1 484 ? -3.175 -6.848 36.541 1.00 27.52 ? 484 TYR A CE1 1 ATOM 3872 C CE2 . TYR A 1 484 ? -1.683 -5.141 35.705 1.00 26.00 ? 484 TYR A CE2 1 ATOM 3873 C CZ . TYR A 1 484 ? -2.962 -5.638 35.905 1.00 25.90 ? 484 TYR A CZ 1 ATOM 3874 O OH . TYR A 1 484 ? -4.006 -4.911 35.455 1.00 23.65 ? 484 TYR A OH 1 ATOM 3875 N N . LYS A 1 485 ? 3.062 -8.674 39.173 1.00 30.66 ? 485 LYS A N 1 ATOM 3876 C CA . LYS A 1 485 ? 3.986 -9.746 39.628 1.00 30.85 ? 485 LYS A CA 1 ATOM 3877 C C . LYS A 1 485 ? 3.959 -11.145 39.053 1.00 30.31 ? 485 LYS A C 1 ATOM 3878 O O . LYS A 1 485 ? 4.749 -11.962 39.487 1.00 30.99 ? 485 LYS A O 1 ATOM 3879 C CB . LYS A 1 485 ? 3.666 -10.285 41.028 1.00 30.55 ? 485 LYS A CB 1 ATOM 3880 C CG . LYS A 1 485 ? 3.356 -9.199 42.037 1.00 32.72 ? 485 LYS A CG 1 ATOM 3881 C CD . LYS A 1 485 ? 4.593 -8.485 42.559 1.00 36.40 ? 485 LYS A CD 1 ATOM 3882 C CE . LYS A 1 485 ? 4.196 -7.154 43.259 1.00 38.69 ? 485 LYS A CE 1 ATOM 3883 N NZ . LYS A 1 485 ? 5.243 -6.090 43.061 1.00 38.79 ? 485 LYS A NZ 1 ATOM 3884 N N . THR A 1 486 ? 3.044 -11.279 37.967 1.00 29.77 ? 486 THR A N 1 ATOM 3885 C CA . THR A 1 486 ? 3.130 -12.376 36.977 1.00 28.95 ? 486 THR A CA 1 ATOM 3886 C C . THR A 1 486 ? 2.290 -11.946 35.755 1.00 29.68 ? 486 THR A C 1 ATOM 3887 O O . THR A 1 486 ? 1.146 -11.477 35.906 1.00 29.32 ? 486 THR A O 1 ATOM 3888 C CB . THR A 1 486 ? 2.795 -13.858 37.390 1.00 28.50 ? 486 THR A CB 1 ATOM 3889 O OG1 . THR A 1 486 ? 2.602 -14.660 36.215 1.00 27.68 ? 486 THR A OG1 1 ATOM 3890 C CG2 . THR A 1 486 ? 1.555 -13.950 38.274 1.00 26.32 ? 486 THR A CG2 1 ATOM 3891 N N . PRO A 1 487 ? 2.839 -12.136 34.535 1.00 30.21 ? 487 PRO A N 1 ATOM 3892 C CA . PRO A 1 487 ? 2.050 -11.898 33.329 1.00 30.51 ? 487 PRO A CA 1 ATOM 3893 C C . PRO A 1 487 ? 0.835 -12.806 33.191 1.00 30.63 ? 487 PRO A C 1 ATOM 3894 O O . PRO A 1 487 ? 0.050 -12.588 32.290 1.00 30.52 ? 487 PRO A O 1 ATOM 3895 C CB . PRO A 1 487 ? 3.047 -12.153 32.198 1.00 30.29 ? 487 PRO A CB 1 ATOM 3896 C CG . PRO A 1 487 ? 4.369 -11.846 32.799 1.00 29.92 ? 487 PRO A CG 1 ATOM 3897 C CD . PRO A 1 487 ? 4.242 -12.423 34.190 1.00 30.77 ? 487 PRO A CD 1 ATOM 3898 N N . ASP A 1 488 ? 0.693 -13.801 34.081 1.00 30.65 ? 488 ASP A N 1 ATOM 3899 C CA . ASP A 1 488 ? -0.537 -14.595 34.202 1.00 29.59 ? 488 ASP A CA 1 ATOM 3900 C C . ASP A 1 488 ? -1.663 -13.749 34.786 1.00 28.78 ? 488 ASP A C 1 ATOM 3901 O O . ASP A 1 488 ? -2.834 -14.064 34.591 1.00 29.18 ? 488 ASP A O 1 ATOM 3902 C CB . ASP A 1 488 ? -0.362 -15.826 35.128 1.00 29.94 ? 488 ASP A CB 1 ATOM 3903 C CG . ASP A 1 488 ? 0.759 -16.768 34.693 1.00 30.81 ? 488 ASP A CG 1 ATOM 3904 O OD1 . ASP A 1 488 ? 1.017 -16.939 33.471 1.00 28.59 ? 488 ASP A OD1 1 ATOM 3905 O OD2 . ASP A 1 488 ? 1.391 -17.332 35.621 1.00 34.64 ? 488 ASP A OD2 1 ATOM 3906 N N . ASN A 1 489 ? -1.316 -12.710 35.539 1.00 27.66 ? 489 ASN A N 1 ATOM 3907 C CA . ASN A 1 489 ? -2.339 -11.887 36.207 1.00 26.44 ? 489 ASN A CA 1 ATOM 3908 C C . ASN A 1 489 ? -2.752 -10.615 35.497 1.00 25.14 ? 489 ASN A C 1 ATOM 3909 O O . ASN A 1 489 ? -3.643 -9.906 35.981 1.00 24.45 ? 489 ASN A O 1 ATOM 3910 C CB . ASN A 1 489 ? -1.908 -11.526 37.623 1.00 26.72 ? 489 ASN A CB 1 ATOM 3911 C CG . ASN A 1 489 ? -2.161 -12.632 38.598 1.00 27.21 ? 489 ASN A CG 1 ATOM 3912 O OD1 . ASN A 1 489 ? -2.360 -13.794 38.210 1.00 25.72 ? 489 ASN A OD1 1 ATOM 3913 N ND2 . ASN A 1 489 ? -2.144 -12.290 39.894 1.00 29.45 ? 489 ASN A ND2 1 ATOM 3914 N N . ILE A 1 490 ? -2.119 -10.314 34.361 1.00 23.54 ? 490 ILE A N 1 ATOM 3915 C CA . ILE A 1 490 ? -2.463 -9.080 33.648 1.00 22.61 ? 490 ILE A CA 1 ATOM 3916 C C . ILE A 1 490 ? -3.915 -9.156 33.150 1.00 21.67 ? 490 ILE A C 1 ATOM 3917 O O . ILE A 1 490 ? -4.392 -10.173 32.636 1.00 21.58 ? 490 ILE A O 1 ATOM 3918 C CB . ILE A 1 490 ? -1.429 -8.694 32.559 1.00 22.55 ? 490 ILE A CB 1 ATOM 3919 C CG1 . ILE A 1 490 ? -0.063 -8.385 33.197 1.00 21.37 ? 490 ILE A CG1 1 ATOM 3920 C CG2 . ILE A 1 490 ? -1.907 -7.494 31.748 1.00 23.79 ? 490 ILE A CG2 1 ATOM 3921 C CD1 . ILE A 1 490 ? 1.167 -8.604 32.253 1.00 16.41 ? 490 ILE A CD1 1 ATOM 3922 N N . ASP A 1 491 ? -4.657 -8.105 33.401 1.00 21.38 ? 491 ASP A N 1 ATOM 3923 C CA . ASP A 1 491 ? -6.040 -8.112 32.978 1.00 20.72 ? 491 ASP A CA 1 ATOM 3924 C C . ASP A 1 491 ? -6.052 -8.077 31.448 1.00 20.61 ? 491 ASP A C 1 ATOM 3925 O O . ASP A 1 491 ? -5.353 -7.268 30.809 1.00 20.08 ? 491 ASP A O 1 ATOM 3926 C CB . ASP A 1 491 ? -6.802 -6.961 33.607 1.00 20.25 ? 491 ASP A CB 1 ATOM 3927 C CG . ASP A 1 491 ? -6.995 -7.127 35.132 1.00 21.21 ? 491 ASP A CG 1 ATOM 3928 O OD1 . ASP A 1 491 ? -7.652 -8.092 35.577 1.00 23.74 ? 491 ASP A OD1 1 ATOM 3929 O OD2 . ASP A 1 491 ? -6.571 -6.245 35.899 1.00 21.05 ? 491 ASP A OD2 1 ATOM 3930 N N . ILE A 1 492 ? -6.812 -9.000 30.860 1.00 20.61 ? 492 ILE A N 1 ATOM 3931 C CA . ILE A 1 492 ? -6.928 -9.046 29.414 1.00 20.01 ? 492 ILE A CA 1 ATOM 3932 C C . ILE A 1 492 ? -7.163 -7.664 28.755 1.00 19.91 ? 492 ILE A C 1 ATOM 3933 O O . ILE A 1 492 ? -6.547 -7.352 27.740 1.00 18.86 ? 492 ILE A O 1 ATOM 3934 C CB . ILE A 1 492 ? -7.908 -10.137 28.921 1.00 19.82 ? 492 ILE A CB 1 ATOM 3935 C CG1 . ILE A 1 492 ? -7.799 -10.290 27.408 1.00 20.43 ? 492 ILE A CG1 1 ATOM 3936 C CG2 . ILE A 1 492 ? -9.330 -9.869 29.363 1.00 19.32 ? 492 ILE A CG2 1 ATOM 3937 C CD1 . ILE A 1 492 ? -6.292 -10.542 26.890 1.00 17.44 ? 492 ILE A CD1 1 ATOM 3938 N N . TRP A 1 493 ? -8.005 -6.813 29.326 1.00 19.68 ? 493 TRP A N 1 ATOM 3939 C CA . TRP A 1 493 ? -8.179 -5.524 28.653 1.00 20.13 ? 493 TRP A CA 1 ATOM 3940 C C . TRP A 1 493 ? -6.864 -4.736 28.523 1.00 21.52 ? 493 TRP A C 1 ATOM 3941 O O . TRP A 1 493 ? -6.688 -3.955 27.585 1.00 20.52 ? 493 TRP A O 1 ATOM 3942 C CB . TRP A 1 493 ? -9.232 -4.639 29.326 1.00 19.38 ? 493 TRP A CB 1 ATOM 3943 C CG . TRP A 1 493 ? -9.373 -3.320 28.685 1.00 14.36 ? 493 TRP A CG 1 ATOM 3944 C CD1 . TRP A 1 493 ? -10.058 -3.051 27.562 1.00 13.90 ? 493 TRP A CD1 1 ATOM 3945 C CD2 . TRP A 1 493 ? -8.783 -2.082 29.099 1.00 11.88 ? 493 TRP A CD2 1 ATOM 3946 N NE1 . TRP A 1 493 ? -9.963 -1.712 27.244 1.00 13.13 ? 493 TRP A NE1 1 ATOM 3947 C CE2 . TRP A 1 493 ? -9.188 -1.100 28.190 1.00 10.90 ? 493 TRP A CE2 1 ATOM 3948 C CE3 . TRP A 1 493 ? -7.953 -1.709 30.150 1.00 11.69 ? 493 TRP A CE3 1 ATOM 3949 C CZ2 . TRP A 1 493 ? -8.801 0.221 28.301 1.00 10.27 ? 493 TRP A CZ2 1 ATOM 3950 C CZ3 . TRP A 1 493 ? -7.559 -0.365 30.254 1.00 10.03 ? 493 TRP A CZ3 1 ATOM 3951 C CH2 . TRP A 1 493 ? -7.982 0.562 29.347 1.00 10.79 ? 493 TRP A CH2 1 ATOM 3952 N N . ILE A 1 494 ? -5.968 -4.886 29.486 1.00 23.16 ? 494 ILE A N 1 ATOM 3953 C CA . ILE A 1 494 ? -4.814 -4.005 29.473 1.00 25.19 ? 494 ILE A CA 1 ATOM 3954 C C . ILE A 1 494 ? -3.663 -4.687 28.742 1.00 25.44 ? 494 ILE A C 1 ATOM 3955 O O . ILE A 1 494 ? -2.882 -4.038 28.081 1.00 26.24 ? 494 ILE A O 1 ATOM 3956 C CB . ILE A 1 494 ? -4.471 -3.364 30.865 1.00 25.04 ? 494 ILE A CB 1 ATOM 3957 C CG1 . ILE A 1 494 ? -3.369 -2.311 30.730 1.00 29.18 ? 494 ILE A CG1 1 ATOM 3958 C CG2 . ILE A 1 494 ? -3.981 -4.394 31.862 1.00 26.96 ? 494 ILE A CG2 1 ATOM 3959 C CD1 . ILE A 1 494 ? -3.645 -1.143 29.754 1.00 29.44 ? 494 ILE A CD1 1 ATOM 3960 N N . GLY A 1 495 ? -3.617 -6.008 28.789 1.00 25.83 ? 495 GLY A N 1 ATOM 3961 C CA . GLY A 1 495 ? -2.549 -6.746 28.143 1.00 25.48 ? 495 GLY A CA 1 ATOM 3962 C C . GLY A 1 495 ? -2.715 -6.853 26.648 1.00 25.52 ? 495 GLY A C 1 ATOM 3963 O O . GLY A 1 495 ? -1.737 -6.788 25.901 1.00 26.28 ? 495 GLY A O 1 ATOM 3964 N N . GLY A 1 496 ? -3.940 -7.037 26.187 1.00 25.11 ? 496 GLY A N 1 ATOM 3965 C CA . GLY A 1 496 ? -4.166 -7.071 24.743 1.00 24.40 ? 496 GLY A CA 1 ATOM 3966 C C . GLY A 1 496 ? -3.891 -5.724 24.106 1.00 24.25 ? 496 GLY A C 1 ATOM 3967 O O . GLY A 1 496 ? -3.355 -5.667 22.993 1.00 25.28 ? 496 GLY A O 1 ATOM 3968 N N . ASN A 1 497 ? -4.258 -4.641 24.803 1.00 23.55 ? 497 ASN A N 1 ATOM 3969 C CA . ASN A 1 497 ? -4.108 -3.274 24.269 1.00 23.37 ? 497 ASN A CA 1 ATOM 3970 C C . ASN A 1 497 ? -2.688 -2.736 24.349 1.00 23.91 ? 497 ASN A C 1 ATOM 3971 O O . ASN A 1 497 ? -2.323 -1.898 23.552 1.00 23.82 ? 497 ASN A O 1 ATOM 3972 C CB . ASN A 1 497 ? -5.032 -2.275 24.982 1.00 22.78 ? 497 ASN A CB 1 ATOM 3973 C CG . ASN A 1 497 ? -6.460 -2.309 24.448 1.00 21.24 ? 497 ASN A CG 1 ATOM 3974 O OD1 . ASN A 1 497 ? -7.398 -2.676 25.156 1.00 23.19 ? 497 ASN A OD1 1 ATOM 3975 N ND2 . ASN A 1 497 ? -6.621 -1.957 23.209 1.00 18.31 ? 497 ASN A ND2 1 ATOM 3976 N N . ALA A 1 498 ? -1.922 -3.199 25.338 1.00 24.13 ? 498 ALA A N 1 ATOM 3977 C CA . ALA A 1 498 ? -0.522 -2.852 25.481 1.00 25.32 ? 498 ALA A CA 1 ATOM 3978 C C . ALA A 1 498 ? 0.334 -3.381 24.342 1.00 25.92 ? 498 ALA A C 1 ATOM 3979 O O . ALA A 1 498 ? 1.413 -2.868 24.127 1.00 26.92 ? 498 ALA A O 1 ATOM 3980 C CB . ALA A 1 498 ? 0.021 -3.356 26.805 1.00 25.49 ? 498 ALA A CB 1 ATOM 3981 N N . GLU A 1 499 ? -0.127 -4.410 23.637 1.00 26.38 ? 499 GLU A N 1 ATOM 3982 C CA . GLU A 1 499 ? 0.662 -4.999 22.554 1.00 27.05 ? 499 GLU A CA 1 ATOM 3983 C C . GLU A 1 499 ? 0.848 -4.012 21.404 1.00 28.07 ? 499 GLU A C 1 ATOM 3984 O O . GLU A 1 499 ? -0.008 -3.156 21.177 1.00 28.28 ? 499 GLU A O 1 ATOM 3985 C CB . GLU A 1 499 ? 0.002 -6.282 22.047 1.00 27.16 ? 499 GLU A CB 1 ATOM 3986 C CG . GLU A 1 499 ? -0.293 -7.301 23.136 1.00 27.52 ? 499 GLU A CG 1 ATOM 3987 C CD . GLU A 1 499 ? -0.361 -8.719 22.604 1.00 28.68 ? 499 GLU A CD 1 ATOM 3988 O OE1 . GLU A 1 499 ? -0.540 -8.888 21.379 1.00 32.86 ? 499 GLU A OE1 1 ATOM 3989 O OE2 . GLU A 1 499 ? -0.235 -9.664 23.410 1.00 27.29 ? 499 GLU A OE2 1 ATOM 3990 N N . PRO A 1 500 ? 1.958 -4.126 20.676 1.00 28.52 ? 500 PRO A N 1 ATOM 3991 C CA . PRO A 1 500 ? 2.197 -3.210 19.557 1.00 27.96 ? 500 PRO A CA 1 ATOM 3992 C C . PRO A 1 500 ? 1.404 -3.628 18.342 1.00 28.14 ? 500 PRO A C 1 ATOM 3993 O O . PRO A 1 500 ? 1.166 -4.804 18.132 1.00 28.24 ? 500 PRO A O 1 ATOM 3994 C CB . PRO A 1 500 ? 3.702 -3.347 19.299 1.00 28.41 ? 500 PRO A CB 1 ATOM 3995 C CG . PRO A 1 500 ? 4.261 -4.015 20.554 1.00 29.00 ? 500 PRO A CG 1 ATOM 3996 C CD . PRO A 1 500 ? 3.147 -4.938 20.978 1.00 27.92 ? 500 PRO A CD 1 ATOM 3997 N N . MET A 1 501 ? 0.992 -2.667 17.538 1.00 28.96 ? 501 MET A N 1 ATOM 3998 C CA . MET A 1 501 ? 0.135 -2.948 16.382 1.00 30.03 ? 501 MET A CA 1 ATOM 3999 C C . MET A 1 501 ? 0.743 -3.915 15.353 1.00 30.49 ? 501 MET A C 1 ATOM 4000 O O . MET A 1 501 ? 1.966 -3.987 15.177 1.00 29.70 ? 501 MET A O 1 ATOM 4001 C CB . MET A 1 501 ? -0.318 -1.636 15.731 1.00 30.16 ? 501 MET A CB 1 ATOM 4002 C CG . MET A 1 501 ? -1.227 -0.823 16.668 1.00 31.18 ? 501 MET A CG 1 ATOM 4003 S SD . MET A 1 501 ? -1.557 0.911 16.214 1.00 32.73 ? 501 MET A SD 1 ATOM 4004 C CE . MET A 1 501 ? -2.314 1.471 17.725 1.00 31.77 ? 501 MET A CE 1 ATOM 4005 N N . VAL A 1 502 ? -0.133 -4.700 14.734 1.00 31.44 ? 502 VAL A N 1 ATOM 4006 C CA . VAL A 1 502 ? 0.233 -5.475 13.586 1.00 32.33 ? 502 VAL A CA 1 ATOM 4007 C C . VAL A 1 502 ? 0.362 -4.503 12.434 1.00 33.17 ? 502 VAL A C 1 ATOM 4008 O O . VAL A 1 502 ? -0.147 -3.370 12.508 1.00 33.28 ? 502 VAL A O 1 ATOM 4009 C CB . VAL A 1 502 ? -0.810 -6.585 13.216 1.00 32.59 ? 502 VAL A CB 1 ATOM 4010 C CG1 . VAL A 1 502 ? -0.824 -7.683 14.265 1.00 31.67 ? 502 VAL A CG1 1 ATOM 4011 C CG2 . VAL A 1 502 ? -2.175 -6.018 12.968 1.00 31.78 ? 502 VAL A CG2 1 ATOM 4012 N N . GLU A 1 503 ? 1.058 -4.960 11.394 1.00 34.08 ? 503 GLU A N 1 ATOM 4013 C CA . GLU A 1 503 ? 1.265 -4.217 10.159 1.00 35.31 ? 503 GLU A CA 1 ATOM 4014 C C . GLU A 1 503 ? -0.085 -3.823 9.564 1.00 35.32 ? 503 GLU A C 1 ATOM 4015 O O . GLU A 1 503 ? -0.908 -4.687 9.238 1.00 35.81 ? 503 GLU A O 1 ATOM 4016 C CB . GLU A 1 503 ? 2.067 -5.059 9.140 1.00 35.36 ? 503 GLU A CB 1 ATOM 4017 C CG . GLU A 1 503 ? 3.592 -5.106 9.324 1.00 38.82 ? 503 GLU A CG 1 ATOM 4018 C CD . GLU A 1 503 ? 4.334 -5.419 7.969 1.00 45.22 ? 503 GLU A CD 1 ATOM 4019 O OE1 . GLU A 1 503 ? 3.877 -4.948 6.892 1.00 46.41 ? 503 GLU A OE1 1 ATOM 4020 O OE2 . GLU A 1 503 ? 5.372 -6.132 7.965 1.00 45.03 ? 503 GLU A OE2 1 ATOM 4021 N N . ARG A 1 504 ? -0.302 -2.515 9.420 1.00 35.65 ? 504 ARG A N 1 ATOM 4022 C CA . ARG A 1 504 ? -1.541 -1.944 8.840 1.00 35.68 ? 504 ARG A CA 1 ATOM 4023 C C . ARG A 1 504 ? -2.729 -2.557 9.623 1.00 34.54 ? 504 ARG A C 1 ATOM 4024 O O . ARG A 1 504 ? -3.714 -2.995 9.001 1.00 34.83 ? 504 ARG A O 1 ATOM 4025 C CB . ARG A 1 504 ? -1.835 -2.520 7.450 1.00 36.55 ? 504 ARG A CB 1 ATOM 4026 C CG . ARG A 1 504 ? -0.665 -2.490 6.430 1.00 40.98 ? 504 ARG A CG 1 ATOM 4027 C CD . ARG A 1 504 ? -0.929 -3.488 5.261 1.00 47.03 ? 504 ARG A CD 1 ATOM 4028 N NE . ARG A 1 504 ? 0.281 -4.199 4.815 1.00 50.96 ? 504 ARG A NE 1 ATOM 4029 C CZ . ARG A 1 504 ? 0.662 -5.412 5.233 1.00 51.95 ? 504 ARG A CZ 1 ATOM 4030 N NH1 . ARG A 1 504 ? -0.061 -6.081 6.116 1.00 51.36 ? 504 ARG A NH1 1 ATOM 4031 N NH2 . ARG A 1 504 ? 1.773 -5.966 4.756 1.00 53.80 ? 504 ARG A NH2 1 ATOM 4032 N N . GLY A 1 505 ? -2.643 -2.585 10.962 1.00 32.63 ? 505 GLY A N 1 ATOM 4033 C CA . GLY A 1 505 ? -3.763 -2.706 11.897 1.00 30.19 ? 505 GLY A CA 1 ATOM 4034 C C . GLY A 1 505 ? -3.776 -1.616 12.960 1.00 28.98 ? 505 GLY A C 1 ATOM 4035 O O . GLY A 1 505 ? -2.947 -0.697 12.950 1.00 28.81 ? 505 GLY A O 1 ATOM 4036 N N . ARG A 1 506 ? -4.717 -1.705 13.888 1.00 27.44 ? 506 ARG A N 1 ATOM 4037 C CA . ARG A 1 506 ? -4.724 -0.801 15.014 1.00 26.12 ? 506 ARG A CA 1 ATOM 4038 C C . ARG A 1 506 ? -4.859 -1.530 16.329 1.00 25.63 ? 506 ARG A C 1 ATOM 4039 O O . ARG A 1 506 ? -4.978 -0.916 17.391 1.00 26.82 ? 506 ARG A O 1 ATOM 4040 C CB . ARG A 1 506 ? -5.781 0.277 14.851 1.00 26.41 ? 506 ARG A CB 1 ATOM 4041 C CG . ARG A 1 506 ? -5.470 1.329 13.742 1.00 26.20 ? 506 ARG A CG 1 ATOM 4042 C CD . ARG A 1 506 ? -4.218 2.164 14.038 1.00 25.72 ? 506 ARG A CD 1 ATOM 4043 N NE . ARG A 1 506 ? -4.019 3.228 13.053 1.00 26.48 ? 506 ARG A NE 1 ATOM 4044 C CZ . ARG A 1 506 ? -3.269 3.121 11.961 1.00 27.07 ? 506 ARG A CZ 1 ATOM 4045 N NH1 . ARG A 1 506 ? -2.620 1.991 11.685 1.00 28.08 ? 506 ARG A NH1 1 ATOM 4046 N NH2 . ARG A 1 506 ? -3.182 4.143 11.128 1.00 29.18 ? 506 ARG A NH2 1 ATOM 4047 N N . VAL A 1 507 ? -4.755 -2.853 16.267 1.00 24.36 ? 507 VAL A N 1 ATOM 4048 C CA . VAL A 1 507 ? -4.557 -3.693 17.457 1.00 22.29 ? 507 VAL A CA 1 ATOM 4049 C C . VAL A 1 507 ? -3.397 -4.648 17.270 1.00 22.09 ? 507 VAL A C 1 ATOM 4050 O O . VAL A 1 507 ? -3.032 -4.986 16.153 1.00 22.34 ? 507 VAL A O 1 ATOM 4051 C CB . VAL A 1 507 ? -5.774 -4.553 17.717 1.00 22.42 ? 507 VAL A CB 1 ATOM 4052 C CG1 . VAL A 1 507 ? -6.997 -3.659 18.037 1.00 22.30 ? 507 VAL A CG1 1 ATOM 4053 C CG2 . VAL A 1 507 ? -6.045 -5.499 16.495 1.00 19.80 ? 507 VAL A CG2 1 ATOM 4054 N N . GLY A 1 508 ? -2.834 -5.102 18.375 1.00 21.82 ? 508 GLY A N 1 ATOM 4055 C CA . GLY A 1 508 ? -1.797 -6.111 18.349 1.00 22.13 ? 508 GLY A CA 1 ATOM 4056 C C . GLY A 1 508 ? -2.324 -7.517 18.141 1.00 22.35 ? 508 GLY A C 1 ATOM 4057 O O . GLY A 1 508 ? -3.548 -7.751 18.225 1.00 22.50 ? 508 GLY A O 1 ATOM 4058 N N . PRO A 1 509 ? -1.402 -8.481 17.925 1.00 21.81 ? 509 PRO A N 1 ATOM 4059 C CA . PRO A 1 509 ? -1.786 -9.839 17.525 1.00 21.13 ? 509 PRO A CA 1 ATOM 4060 C C . PRO A 1 509 ? -2.808 -10.551 18.435 1.00 20.04 ? 509 PRO A C 1 ATOM 4061 O O . PRO A 1 509 ? -3.603 -11.331 17.921 1.00 20.51 ? 509 PRO A O 1 ATOM 4062 C CB . PRO A 1 509 ? -0.451 -10.604 17.508 1.00 19.77 ? 509 PRO A CB 1 ATOM 4063 C CG . PRO A 1 509 ? 0.369 -9.880 18.505 1.00 20.71 ? 509 PRO A CG 1 ATOM 4064 C CD . PRO A 1 509 ? 0.007 -8.423 18.347 1.00 21.71 ? 509 PRO A CD 1 ATOM 4065 N N . LEU A 1 510 ? -2.764 -10.356 19.744 1.00 20.15 ? 510 LEU A N 1 ATOM 4066 C CA . LEU A 1 510 ? -3.766 -11.037 20.616 1.00 20.42 ? 510 LEU A CA 1 ATOM 4067 C C . LEU A 1 510 ? -5.165 -10.507 20.363 1.00 20.13 ? 510 LEU A C 1 ATOM 4068 O O . LEU A 1 510 ? -6.081 -11.289 20.191 1.00 21.12 ? 510 LEU A O 1 ATOM 4069 C CB . LEU A 1 510 ? -3.457 -10.924 22.115 1.00 20.70 ? 510 LEU A CB 1 ATOM 4070 C CG . LEU A 1 510 ? -4.483 -11.426 23.182 1.00 20.54 ? 510 LEU A CG 1 ATOM 4071 C CD1 . LEU A 1 510 ? -4.935 -12.883 23.027 1.00 17.14 ? 510 LEU A CD1 1 ATOM 4072 C CD2 . LEU A 1 510 ? -3.879 -11.270 24.553 1.00 16.79 ? 510 LEU A CD2 1 ATOM 4073 N N . LEU A 1 511 ? -5.321 -9.187 20.328 1.00 19.24 ? 511 LEU A N 1 ATOM 4074 C CA . LEU A 1 511 ? -6.612 -8.621 19.999 1.00 18.86 ? 511 LEU A CA 1 ATOM 4075 C C . LEU A 1 511 ? -7.090 -9.028 18.601 1.00 18.91 ? 511 LEU A C 1 ATOM 4076 O O . LEU A 1 511 ? -8.237 -9.423 18.436 1.00 19.58 ? 511 LEU A O 1 ATOM 4077 C CB . LEU A 1 511 ? -6.616 -7.095 20.186 1.00 18.15 ? 511 LEU A CB 1 ATOM 4078 C CG . LEU A 1 511 ? -6.435 -6.704 21.667 1.00 19.19 ? 511 LEU A CG 1 ATOM 4079 C CD1 . LEU A 1 511 ? -6.514 -5.177 21.863 1.00 16.58 ? 511 LEU A CD1 1 ATOM 4080 C CD2 . LEU A 1 511 ? -7.415 -7.417 22.594 1.00 17.20 ? 511 LEU A CD2 1 ATOM 4081 N N . ALA A 1 512 ? -6.232 -8.922 17.587 1.00 19.23 ? 512 ALA A N 1 ATOM 4082 C CA . ALA A 1 512 ? -6.604 -9.376 16.237 1.00 19.55 ? 512 ALA A CA 1 ATOM 4083 C C . ALA A 1 512 ? -7.100 -10.816 16.209 1.00 19.52 ? 512 ALA A C 1 ATOM 4084 O O . ALA A 1 512 ? -7.984 -11.147 15.444 1.00 19.62 ? 512 ALA A O 1 ATOM 4085 C CB . ALA A 1 512 ? -5.469 -9.203 15.261 1.00 19.91 ? 512 ALA A CB 1 ATOM 4086 N N . CYS A 1 513 ? -6.533 -11.672 17.044 1.00 20.28 ? 513 CYS A N 1 ATOM 4087 C CA . CYS A 1 513 ? -7.067 -13.039 17.224 1.00 21.34 ? 513 CYS A CA 1 ATOM 4088 C C . CYS A 1 513 ? -8.467 -13.040 17.828 1.00 20.41 ? 513 CYS A C 1 ATOM 4089 O O . CYS A 1 513 ? -9.354 -13.629 17.274 1.00 20.09 ? 513 CYS A O 1 ATOM 4090 C CB . CYS A 1 513 ? -6.105 -13.853 18.089 1.00 21.90 ? 513 CYS A CB 1 ATOM 4091 S SG . CYS A 1 513 ? -6.690 -15.442 18.691 1.00 25.83 ? 513 CYS A SG 1 ATOM 4092 N N . LEU A 1 514 ? -8.659 -12.344 18.943 1.00 20.23 ? 514 LEU A N 1 ATOM 4093 C CA . LEU A 1 514 ? -9.968 -12.290 19.599 1.00 20.48 ? 514 LEU A CA 1 ATOM 4094 C C . LEU A 1 514 ? -11.030 -11.629 18.728 1.00 21.37 ? 514 LEU A C 1 ATOM 4095 O O . LEU A 1 514 ? -12.068 -12.221 18.455 1.00 20.84 ? 514 LEU A O 1 ATOM 4096 C CB . LEU A 1 514 ? -9.844 -11.620 20.970 1.00 20.47 ? 514 LEU A CB 1 ATOM 4097 C CG . LEU A 1 514 ? -9.047 -12.448 22.014 1.00 19.94 ? 514 LEU A CG 1 ATOM 4098 C CD1 . LEU A 1 514 ? -8.684 -11.644 23.246 1.00 17.11 ? 514 LEU A CD1 1 ATOM 4099 C CD2 . LEU A 1 514 ? -9.812 -13.706 22.429 1.00 20.69 ? 514 LEU A CD2 1 ATOM 4100 N N . LEU A 1 515 ? -10.733 -10.421 18.242 1.00 22.17 ? 515 LEU A N 1 ATOM 4101 C CA . LEU A 1 515 ? -11.552 -9.777 17.220 1.00 22.42 ? 515 LEU A CA 1 ATOM 4102 C C . LEU A 1 515 ? -11.797 -10.606 15.965 1.00 22.31 ? 515 LEU A C 1 ATOM 4103 O O . LEU A 1 515 ? -12.918 -10.711 15.531 1.00 22.85 ? 515 LEU A O 1 ATOM 4104 C CB . LEU A 1 515 ? -10.972 -8.426 16.828 1.00 22.07 ? 515 LEU A CB 1 ATOM 4105 C CG . LEU A 1 515 ? -10.746 -7.562 18.065 1.00 21.52 ? 515 LEU A CG 1 ATOM 4106 C CD1 . LEU A 1 515 ? -9.855 -6.324 17.776 1.00 19.46 ? 515 LEU A CD1 1 ATOM 4107 C CD2 . LEU A 1 515 ? -12.071 -7.198 18.553 1.00 18.54 ? 515 LEU A CD2 1 ATOM 4108 N N . GLY A 1 516 ? -10.755 -11.163 15.362 1.00 22.77 ? 516 GLY A N 1 ATOM 4109 C CA . GLY A 1 516 ? -10.903 -11.837 14.070 1.00 22.15 ? 516 GLY A CA 1 ATOM 4110 C C . GLY A 1 516 ? -11.841 -13.016 14.169 1.00 22.41 ? 516 GLY A C 1 ATOM 4111 O O . GLY A 1 516 ? -12.852 -13.044 13.493 1.00 22.67 ? 516 GLY A O 1 ATOM 4112 N N . ARG A 1 517 ? -11.529 -13.970 15.045 1.00 22.33 ? 517 ARG A N 1 ATOM 4113 C CA . ARG A 1 517 ? -12.459 -15.035 15.356 1.00 23.33 ? 517 ARG A CA 1 ATOM 4114 C C . ARG A 1 517 ? -13.924 -14.555 15.500 1.00 22.68 ? 517 ARG A C 1 ATOM 4115 O O . ARG A 1 517 ? -14.834 -15.124 14.870 1.00 22.34 ? 517 ARG A O 1 ATOM 4116 C CB . ARG A 1 517 ? -12.064 -15.741 16.632 1.00 23.75 ? 517 ARG A CB 1 ATOM 4117 C CG . ARG A 1 517 ? -10.865 -16.623 16.520 1.00 29.28 ? 517 ARG A CG 1 ATOM 4118 C CD . ARG A 1 517 ? -10.494 -17.127 17.906 1.00 35.10 ? 517 ARG A CD 1 ATOM 4119 N NE . ARG A 1 517 ? -9.123 -17.642 18.041 1.00 39.27 ? 517 ARG A NE 1 ATOM 4120 C CZ . ARG A 1 517 ? -8.764 -18.907 17.800 1.00 43.04 ? 517 ARG A CZ 1 ATOM 4121 N NH1 . ARG A 1 517 ? -7.493 -19.293 17.980 1.00 42.57 ? 517 ARG A NH1 1 ATOM 4122 N NH2 . ARG A 1 517 ? -9.673 -19.786 17.365 1.00 42.86 ? 517 ARG A NH2 1 ATOM 4123 N N . GLN A 1 518 ? -14.156 -13.535 16.326 1.00 21.69 ? 518 GLN A N 1 ATOM 4124 C CA . GLN A 1 518 ? -15.540 -13.156 16.650 1.00 21.09 ? 518 GLN A CA 1 ATOM 4125 C C . GLN A 1 518 ? -16.321 -12.650 15.425 1.00 20.76 ? 518 GLN A C 1 ATOM 4126 O O . GLN A 1 518 ? -17.460 -13.127 15.173 1.00 20.11 ? 518 GLN A O 1 ATOM 4127 C CB . GLN A 1 518 ? -15.623 -12.164 17.827 1.00 21.15 ? 518 GLN A CB 1 ATOM 4128 C CG . GLN A 1 518 ? -17.068 -11.841 18.258 1.00 20.54 ? 518 GLN A CG 1 ATOM 4129 C CD . GLN A 1 518 ? -17.703 -12.955 19.063 1.00 20.93 ? 518 GLN A CD 1 ATOM 4130 O OE1 . GLN A 1 518 ? -17.437 -13.101 20.280 1.00 21.99 ? 518 GLN A OE1 1 ATOM 4131 N NE2 . GLN A 1 518 ? -18.548 -13.755 18.405 1.00 18.40 ? 518 GLN A NE2 1 ATOM 4132 N N . PHE A 1 519 ? -15.701 -11.739 14.659 1.00 19.57 ? 519 PHE A N 1 ATOM 4133 C CA . PHE A 1 519 ? -16.273 -11.227 13.418 1.00 19.62 ? 519 PHE A CA 1 ATOM 4134 C C . PHE A 1 519 ? -16.476 -12.286 12.346 1.00 20.47 ? 519 PHE A C 1 ATOM 4135 O O . PHE A 1 519 ? -17.466 -12.252 11.626 1.00 21.03 ? 519 PHE A O 1 ATOM 4136 C CB . PHE A 1 519 ? -15.492 -10.042 12.881 1.00 20.48 ? 519 PHE A CB 1 ATOM 4137 C CG . PHE A 1 519 ? -15.732 -8.746 13.664 1.00 19.80 ? 519 PHE A CG 1 ATOM 4138 C CD1 . PHE A 1 519 ? -16.893 -8.005 13.473 1.00 17.04 ? 519 PHE A CD1 1 ATOM 4139 C CD2 . PHE A 1 519 ? -14.808 -8.302 14.581 1.00 16.28 ? 519 PHE A CD2 1 ATOM 4140 C CE1 . PHE A 1 519 ? -17.110 -6.839 14.173 1.00 19.51 ? 519 PHE A CE1 1 ATOM 4141 C CE2 . PHE A 1 519 ? -15.017 -7.131 15.295 1.00 17.33 ? 519 PHE A CE2 1 ATOM 4142 C CZ . PHE A 1 519 ? -16.168 -6.392 15.087 1.00 18.40 ? 519 PHE A CZ 1 ATOM 4143 N N . GLN A 1 520 ? -15.567 -13.252 12.267 1.00 21.25 ? 520 GLN A N 1 ATOM 4144 C CA . GLN A 1 520 ? -15.776 -14.437 11.429 1.00 21.26 ? 520 GLN A CA 1 ATOM 4145 C C . GLN A 1 520 ? -16.998 -15.188 11.902 1.00 21.22 ? 520 GLN A C 1 ATOM 4146 O O . GLN A 1 520 ? -17.840 -15.592 11.097 1.00 21.07 ? 520 GLN A O 1 ATOM 4147 C CB . GLN A 1 520 ? -14.562 -15.378 11.459 1.00 20.71 ? 520 GLN A CB 1 ATOM 4148 C CG . GLN A 1 520 ? -14.781 -16.704 10.701 1.00 21.13 ? 520 GLN A CG 1 ATOM 4149 C CD . GLN A 1 520 ? -14.900 -17.901 11.644 1.00 25.69 ? 520 GLN A CD 1 ATOM 4150 O OE1 . GLN A 1 520 ? -14.167 -17.988 12.660 1.00 25.09 ? 520 GLN A OE1 1 ATOM 4151 N NE2 . GLN A 1 520 ? -15.827 -18.827 11.328 1.00 22.32 ? 520 GLN A NE2 1 ATOM 4152 N N . GLN A 1 521 ? -17.089 -15.402 13.203 1.00 21.52 ? 521 GLN A N 1 ATOM 4153 C CA . GLN A 1 521 ? -18.274 -16.068 13.736 1.00 22.55 ? 521 GLN A CA 1 ATOM 4154 C C . GLN A 1 521 ? -19.583 -15.337 13.500 1.00 21.97 ? 521 GLN A C 1 ATOM 4155 O O . GLN A 1 521 ? -20.507 -15.944 13.086 1.00 21.56 ? 521 GLN A O 1 ATOM 4156 C CB . GLN A 1 521 ? -18.086 -16.420 15.197 1.00 23.05 ? 521 GLN A CB 1 ATOM 4157 C CG . GLN A 1 521 ? -17.269 -17.643 15.346 1.00 22.37 ? 521 GLN A CG 1 ATOM 4158 C CD . GLN A 1 521 ? -16.930 -17.869 16.735 1.00 24.59 ? 521 GLN A CD 1 ATOM 4159 O OE1 . GLN A 1 521 ? -15.803 -18.239 17.056 1.00 28.94 ? 521 GLN A OE1 1 ATOM 4160 N NE2 . GLN A 1 521 ? -17.883 -17.627 17.610 1.00 30.16 ? 521 GLN A NE2 1 ATOM 4161 N N . ILE A 1 522 ? -19.639 -14.021 13.684 1.00 23.83 ? 522 ILE A N 1 ATOM 4162 C CA . ILE A 1 522 ? -20.856 -13.256 13.299 1.00 24.16 ? 522 ILE A CA 1 ATOM 4163 C C . ILE A 1 522 ? -21.183 -13.165 11.791 1.00 24.30 ? 522 ILE A C 1 ATOM 4164 O O . ILE A 1 522 ? -22.312 -12.914 11.433 1.00 23.57 ? 522 ILE A O 1 ATOM 4165 C CB . ILE A 1 522 ? -20.929 -11.875 13.954 1.00 24.74 ? 522 ILE A CB 1 ATOM 4166 C CG1 . ILE A 1 522 ? -19.898 -10.943 13.381 1.00 24.75 ? 522 ILE A CG1 1 ATOM 4167 C CG2 . ILE A 1 522 ? -20.791 -11.977 15.530 1.00 24.85 ? 522 ILE A CG2 1 ATOM 4168 C CD1 . ILE A 1 522 ? -19.366 -9.985 14.452 1.00 32.73 ? 522 ILE A CD1 1 ATOM 4169 N N . ARG A 1 523 ? -20.212 -13.364 10.908 1.00 25.14 ? 523 ARG A N 1 ATOM 4170 C CA . ARG A 1 523 ? -20.531 -13.448 9.479 1.00 25.70 ? 523 ARG A CA 1 ATOM 4171 C C . ARG A 1 523 ? -21.067 -14.837 9.113 1.00 26.22 ? 523 ARG A C 1 ATOM 4172 O O . ARG A 1 523 ? -22.188 -14.956 8.558 1.00 26.63 ? 523 ARG A O 1 ATOM 4173 C CB . ARG A 1 523 ? -19.318 -13.139 8.623 1.00 25.60 ? 523 ARG A CB 1 ATOM 4174 C CG . ARG A 1 523 ? -19.632 -13.168 7.142 1.00 25.65 ? 523 ARG A CG 1 ATOM 4175 C CD . ARG A 1 523 ? -18.355 -12.999 6.301 1.00 24.31 ? 523 ARG A CD 1 ATOM 4176 N NE . ARG A 1 523 ? -17.471 -14.134 6.468 1.00 21.51 ? 523 ARG A NE 1 ATOM 4177 C CZ . ARG A 1 523 ? -16.239 -14.185 6.000 1.00 25.20 ? 523 ARG A CZ 1 ATOM 4178 N NH1 . ARG A 1 523 ? -15.746 -13.156 5.334 1.00 25.93 ? 523 ARG A NH1 1 ATOM 4179 N NH2 . ARG A 1 523 ? -15.494 -15.262 6.201 1.00 27.08 ? 523 ARG A NH2 1 ATOM 4180 N N . ASP A 1 524 ? -20.285 -15.874 9.432 1.00 25.78 ? 524 ASP A N 1 ATOM 4181 C CA . ASP A 1 524 ? -20.610 -17.232 9.034 1.00 26.02 ? 524 ASP A CA 1 ATOM 4182 C C . ASP A 1 524 ? -21.850 -17.811 9.702 1.00 27.05 ? 524 ASP A C 1 ATOM 4183 O O . ASP A 1 524 ? -22.558 -18.615 9.100 1.00 28.03 ? 524 ASP A O 1 ATOM 4184 C CB . ASP A 1 524 ? -19.418 -18.147 9.247 1.00 26.15 ? 524 ASP A CB 1 ATOM 4185 C CG . ASP A 1 524 ? -18.179 -17.705 8.421 1.00 26.78 ? 524 ASP A CG 1 ATOM 4186 O OD1 . ASP A 1 524 ? -18.323 -16.848 7.534 1.00 27.27 ? 524 ASP A OD1 1 ATOM 4187 O OD2 . ASP A 1 524 ? -17.058 -18.177 8.683 1.00 25.29 ? 524 ASP A OD2 1 ATOM 4188 N N . GLY A 1 525 ? -22.142 -17.415 10.935 1.00 27.30 ? 525 GLY A N 1 ATOM 4189 C CA . GLY A 1 525 ? -23.208 -18.074 11.685 1.00 26.86 ? 525 GLY A CA 1 ATOM 4190 C C . GLY A 1 525 ? -24.533 -17.388 11.499 1.00 27.34 ? 525 GLY A C 1 ATOM 4191 O O . GLY A 1 525 ? -25.507 -17.716 12.192 1.00 27.54 ? 525 GLY A O 1 ATOM 4192 N N . ASP A 1 526 ? -24.563 -16.434 10.561 1.00 27.62 ? 526 ASP A N 1 ATOM 4193 C CA . ASP A 1 526 ? -25.701 -15.536 10.342 1.00 27.67 ? 526 ASP A CA 1 ATOM 4194 C C . ASP A 1 526 ? -26.476 -15.987 9.114 1.00 27.96 ? 526 ASP A C 1 ATOM 4195 O O . ASP A 1 526 ? -26.050 -15.792 7.975 1.00 27.65 ? 526 ASP A O 1 ATOM 4196 C CB . ASP A 1 526 ? -25.223 -14.081 10.172 1.00 27.32 ? 526 ASP A CB 1 ATOM 4197 C CG . ASP A 1 526 ? -26.369 -13.039 10.272 1.00 28.96 ? 526 ASP A CG 1 ATOM 4198 O OD1 . ASP A 1 526 ? -27.502 -13.355 10.689 1.00 29.50 ? 526 ASP A OD1 1 ATOM 4199 O OD2 . ASP A 1 526 ? -26.126 -11.861 9.952 1.00 31.53 ? 526 ASP A OD2 1 ATOM 4200 N N . ARG A 1 527 ? -27.635 -16.591 9.354 1.00 28.90 ? 527 ARG A N 1 ATOM 4201 C CA . ARG A 1 527 ? -28.506 -16.967 8.259 1.00 29.52 ? 527 ARG A CA 1 ATOM 4202 C C . ARG A 1 527 ? -28.788 -15.789 7.310 1.00 29.81 ? 527 ARG A C 1 ATOM 4203 O O . ARG A 1 527 ? -28.852 -15.997 6.112 1.00 30.50 ? 527 ARG A O 1 ATOM 4204 C CB . ARG A 1 527 ? -29.814 -17.597 8.772 1.00 28.99 ? 527 ARG A CB 1 ATOM 4205 C CG . ARG A 1 527 ? -30.650 -18.173 7.609 1.00 29.22 ? 527 ARG A CG 1 ATOM 4206 C CD . ARG A 1 527 ? -31.612 -19.294 7.997 1.00 29.85 ? 527 ARG A CD 1 ATOM 4207 N NE . ARG A 1 527 ? -32.525 -18.898 9.068 1.00 32.75 ? 527 ARG A NE 1 ATOM 4208 C CZ . ARG A 1 527 ? -33.734 -18.372 8.883 1.00 32.38 ? 527 ARG A CZ 1 ATOM 4209 N NH1 . ARG A 1 527 ? -34.194 -18.181 7.660 1.00 35.66 ? 527 ARG A NH1 1 ATOM 4210 N NH2 . ARG A 1 527 ? -34.486 -18.044 9.921 1.00 31.45 ? 527 ARG A NH2 1 ATOM 4211 N N . PHE A 1 528 ? -28.949 -14.577 7.857 1.00 29.91 ? 528 PHE A N 1 ATOM 4212 C CA . PHE A 1 528 ? -29.327 -13.381 7.091 1.00 30.38 ? 528 PHE A CA 1 ATOM 4213 C C . PHE A 1 528 ? -28.167 -12.458 6.772 1.00 30.60 ? 528 PHE A C 1 ATOM 4214 O O . PHE A 1 528 ? -28.362 -11.241 6.657 1.00 30.10 ? 528 PHE A O 1 ATOM 4215 C CB . PHE A 1 528 ? -30.406 -12.561 7.828 1.00 30.42 ? 528 PHE A CB 1 ATOM 4216 C CG . PHE A 1 528 ? -31.622 -13.342 8.163 1.00 30.12 ? 528 PHE A CG 1 ATOM 4217 C CD1 . PHE A 1 528 ? -31.668 -14.104 9.324 1.00 30.18 ? 528 PHE A CD1 1 ATOM 4218 C CD2 . PHE A 1 528 ? -32.714 -13.342 7.305 1.00 28.82 ? 528 PHE A CD2 1 ATOM 4219 C CE1 . PHE A 1 528 ? -32.783 -14.855 9.628 1.00 28.79 ? 528 PHE A CE1 1 ATOM 4220 C CE2 . PHE A 1 528 ? -33.826 -14.071 7.595 1.00 28.24 ? 528 PHE A CE2 1 ATOM 4221 C CZ . PHE A 1 528 ? -33.864 -14.839 8.765 1.00 28.95 ? 528 PHE A CZ 1 ATOM 4222 N N . TRP A 1 529 ? -26.963 -13.015 6.682 1.00 31.10 ? 529 TRP A N 1 ATOM 4223 C CA . TRP A 1 529 ? -25.849 -12.269 6.141 1.00 31.59 ? 529 TRP A CA 1 ATOM 4224 C C . TRP A 1 529 ? -26.184 -11.816 4.729 1.00 32.68 ? 529 TRP A C 1 ATOM 4225 O O . TRP A 1 529 ? -26.455 -12.626 3.821 1.00 33.27 ? 529 TRP A O 1 ATOM 4226 C CB . TRP A 1 529 ? -24.586 -13.102 6.142 1.00 31.70 ? 529 TRP A CB 1 ATOM 4227 C CG . TRP A 1 529 ? -23.340 -12.331 5.710 1.00 31.87 ? 529 TRP A CG 1 ATOM 4228 C CD1 . TRP A 1 529 ? -22.691 -12.434 4.516 1.00 30.17 ? 529 TRP A CD1 1 ATOM 4229 C CD2 . TRP A 1 529 ? -22.608 -11.359 6.480 1.00 30.76 ? 529 TRP A CD2 1 ATOM 4230 N NE1 . TRP A 1 529 ? -21.598 -11.608 4.498 1.00 31.03 ? 529 TRP A NE1 1 ATOM 4231 C CE2 . TRP A 1 529 ? -21.531 -10.920 5.675 1.00 29.33 ? 529 TRP A CE2 1 ATOM 4232 C CE3 . TRP A 1 529 ? -22.754 -10.827 7.773 1.00 30.48 ? 529 TRP A CE3 1 ATOM 4233 C CZ2 . TRP A 1 529 ? -20.609 -9.977 6.109 1.00 30.66 ? 529 TRP A CZ2 1 ATOM 4234 C CZ3 . TRP A 1 529 ? -21.832 -9.881 8.210 1.00 28.81 ? 529 TRP A CZ3 1 ATOM 4235 C CH2 . TRP A 1 529 ? -20.778 -9.463 7.382 1.00 30.11 ? 529 TRP A CH2 1 ATOM 4236 N N . TRP A 1 530 ? -26.163 -10.505 4.554 1.00 33.47 ? 530 TRP A N 1 ATOM 4237 C CA . TRP A 1 530 ? -26.472 -9.854 3.289 1.00 34.25 ? 530 TRP A CA 1 ATOM 4238 C C . TRP A 1 530 ? -25.981 -10.622 2.027 1.00 34.97 ? 530 TRP A C 1 ATOM 4239 O O . TRP A 1 530 ? -26.635 -10.597 0.989 1.00 34.64 ? 530 TRP A O 1 ATOM 4240 C CB . TRP A 1 530 ? -25.896 -8.441 3.310 1.00 33.49 ? 530 TRP A CB 1 ATOM 4241 C CG . TRP A 1 530 ? -24.440 -8.357 2.907 1.00 32.54 ? 530 TRP A CG 1 ATOM 4242 C CD1 . TRP A 1 530 ? -23.358 -8.417 3.728 1.00 31.12 ? 530 TRP A CD1 1 ATOM 4243 C CD2 . TRP A 1 530 ? -23.921 -8.203 1.578 1.00 32.27 ? 530 TRP A CD2 1 ATOM 4244 N NE1 . TRP A 1 530 ? -22.192 -8.316 2.999 1.00 29.23 ? 530 TRP A NE1 1 ATOM 4245 C CE2 . TRP A 1 530 ? -22.511 -8.174 1.678 1.00 31.90 ? 530 TRP A CE2 1 ATOM 4246 C CE3 . TRP A 1 530 ? -24.511 -8.104 0.313 1.00 34.48 ? 530 TRP A CE3 1 ATOM 4247 C CZ2 . TRP A 1 530 ? -21.678 -8.034 0.563 1.00 33.19 ? 530 TRP A CZ2 1 ATOM 4248 C CZ3 . TRP A 1 530 ? -23.684 -7.957 -0.807 1.00 34.39 ? 530 TRP A CZ3 1 ATOM 4249 C CH2 . TRP A 1 530 ? -22.278 -7.925 -0.667 1.00 35.13 ? 530 TRP A CH2 1 ATOM 4250 N N . GLU A 1 531 ? -24.822 -11.275 2.142 1.00 36.14 ? 531 GLU A N 1 ATOM 4251 C CA . GLU A 1 531 ? -24.128 -11.923 1.028 1.00 36.83 ? 531 GLU A CA 1 ATOM 4252 C C . GLU A 1 531 ? -24.488 -13.417 1.020 1.00 36.89 ? 531 GLU A C 1 ATOM 4253 O O . GLU A 1 531 ? -24.024 -14.183 0.178 1.00 36.78 ? 531 GLU A O 1 ATOM 4254 C CB . GLU A 1 531 ? -22.614 -11.720 1.202 1.00 37.21 ? 531 GLU A CB 1 ATOM 4255 C CG . GLU A 1 531 ? -21.731 -11.869 -0.045 1.00 40.36 ? 531 GLU A CG 1 ATOM 4256 C CD . GLU A 1 531 ? -20.225 -11.719 0.273 1.00 45.28 ? 531 GLU A CD 1 ATOM 4257 O OE1 . GLU A 1 531 ? -19.851 -11.483 1.464 1.00 47.15 ? 531 GLU A OE1 1 ATOM 4258 O OE2 . GLU A 1 531 ? -19.408 -11.835 -0.674 1.00 45.22 ? 531 GLU A OE2 1 ATOM 4259 N N . ASN A 1 532 ? -25.318 -13.841 1.968 1.00 37.21 ? 532 ASN A N 1 ATOM 4260 C CA . ASN A 1 532 ? -25.751 -15.224 1.948 1.00 37.85 ? 532 ASN A CA 1 ATOM 4261 C C . ASN A 1 532 ? -26.827 -15.293 0.891 1.00 38.84 ? 532 ASN A C 1 ATOM 4262 O O . ASN A 1 532 ? -27.877 -14.660 1.035 1.00 39.34 ? 532 ASN A O 1 ATOM 4263 C CB . ASN A 1 532 ? -26.262 -15.686 3.305 1.00 37.14 ? 532 ASN A CB 1 ATOM 4264 C CG . ASN A 1 532 ? -26.756 -17.112 3.295 1.00 35.68 ? 532 ASN A CG 1 ATOM 4265 O OD1 . ASN A 1 532 ? -27.710 -17.438 3.977 1.00 33.59 ? 532 ASN A OD1 1 ATOM 4266 N ND2 . ASN A 1 532 ? -26.105 -17.974 2.524 1.00 37.65 ? 532 ASN A ND2 1 ATOM 4267 N N . PRO A 1 533 ? -26.563 -16.036 -0.197 1.00 39.67 ? 533 PRO A N 1 ATOM 4268 C CA . PRO A 1 533 ? -27.516 -16.036 -1.306 1.00 39.91 ? 533 PRO A CA 1 ATOM 4269 C C . PRO A 1 533 ? -28.863 -16.549 -0.821 1.00 39.87 ? 533 PRO A C 1 ATOM 4270 O O . PRO A 1 533 ? -28.914 -17.522 -0.099 1.00 40.56 ? 533 PRO A O 1 ATOM 4271 C CB . PRO A 1 533 ? -26.861 -16.970 -2.321 1.00 40.02 ? 533 PRO A CB 1 ATOM 4272 C CG . PRO A 1 533 ? -25.954 -17.821 -1.510 1.00 40.11 ? 533 PRO A CG 1 ATOM 4273 C CD . PRO A 1 533 ? -25.423 -16.931 -0.453 1.00 39.62 ? 533 PRO A CD 1 ATOM 4274 N N . GLY A 1 534 ? -29.935 -15.848 -1.148 1.00 40.05 ? 534 GLY A N 1 ATOM 4275 C CA . GLY A 1 534 ? -31.254 -16.224 -0.652 1.00 40.81 ? 534 GLY A CA 1 ATOM 4276 C C . GLY A 1 534 ? -31.831 -15.094 0.162 1.00 40.96 ? 534 GLY A C 1 ATOM 4277 O O . GLY A 1 534 ? -33.027 -15.029 0.391 1.00 41.99 ? 534 GLY A O 1 ATOM 4278 N N . VAL A 1 535 ? -30.966 -14.188 0.588 1.00 41.04 ? 535 VAL A N 1 ATOM 4279 C CA . VAL A 1 535 ? -31.366 -13.082 1.434 1.00 40.85 ? 535 VAL A CA 1 ATOM 4280 C C . VAL A 1 535 ? -31.696 -11.879 0.531 1.00 40.98 ? 535 VAL A C 1 ATOM 4281 O O . VAL A 1 535 ? -32.760 -11.294 0.659 1.00 40.92 ? 535 VAL A O 1 ATOM 4282 C CB . VAL A 1 535 ? -30.278 -12.785 2.512 1.00 41.04 ? 535 VAL A CB 1 ATOM 4283 C CG1 . VAL A 1 535 ? -30.683 -11.608 3.415 1.00 40.41 ? 535 VAL A CG1 1 ATOM 4284 C CG2 . VAL A 1 535 ? -29.986 -14.048 3.350 1.00 39.87 ? 535 VAL A CG2 1 ATOM 4285 N N . PHE A 1 536 ? -30.800 -11.542 -0.387 1.00 41.13 ? 536 PHE A N 1 ATOM 4286 C CA . PHE A 1 536 ? -31.083 -10.556 -1.432 1.00 42.19 ? 536 PHE A CA 1 ATOM 4287 C C . PHE A 1 536 ? -30.939 -11.232 -2.798 1.00 43.17 ? 536 PHE A C 1 ATOM 4288 O O . PHE A 1 536 ? -30.514 -12.389 -2.870 1.00 43.22 ? 536 PHE A O 1 ATOM 4289 C CB . PHE A 1 536 ? -30.122 -9.361 -1.350 1.00 41.66 ? 536 PHE A CB 1 ATOM 4290 C CG . PHE A 1 536 ? -30.271 -8.528 -0.099 1.00 40.65 ? 536 PHE A CG 1 ATOM 4291 C CD1 . PHE A 1 536 ? -29.390 -8.698 0.978 1.00 38.63 ? 536 PHE A CD1 1 ATOM 4292 C CD2 . PHE A 1 536 ? -31.263 -7.557 -0.007 1.00 39.58 ? 536 PHE A CD2 1 ATOM 4293 C CE1 . PHE A 1 536 ? -29.488 -7.920 2.130 1.00 37.32 ? 536 PHE A CE1 1 ATOM 4294 C CE2 . PHE A 1 536 ? -31.381 -6.753 1.136 1.00 39.50 ? 536 PHE A CE2 1 ATOM 4295 C CZ . PHE A 1 536 ? -30.491 -6.949 2.222 1.00 39.82 ? 536 PHE A CZ 1 ATOM 4296 N N . THR A 1 537 ? -31.286 -10.519 -3.867 1.00 43.79 ? 537 THR A N 1 ATOM 4297 C CA . THR A 1 537 ? -31.175 -11.062 -5.212 1.00 45.15 ? 537 THR A CA 1 ATOM 4298 C C . THR A 1 537 ? -29.837 -10.699 -5.818 1.00 46.41 ? 537 THR A C 1 ATOM 4299 O O . THR A 1 537 ? -29.214 -9.710 -5.426 1.00 46.66 ? 537 THR A O 1 ATOM 4300 C CB . THR A 1 537 ? -32.270 -10.530 -6.173 1.00 45.11 ? 537 THR A CB 1 ATOM 4301 O OG1 . THR A 1 537 ? -31.893 -9.232 -6.661 1.00 44.79 ? 537 THR A OG1 1 ATOM 4302 C CG2 . THR A 1 537 ? -33.657 -10.486 -5.496 1.00 43.65 ? 537 THR A CG2 1 ATOM 4303 N N . GLU A 1 538 ? -29.408 -11.509 -6.783 1.00 48.01 ? 538 GLU A N 1 ATOM 4304 C CA . GLU A 1 538 ? -28.229 -11.225 -7.595 1.00 49.72 ? 538 GLU A CA 1 ATOM 4305 C C . GLU A 1 538 ? -28.145 -9.709 -7.798 1.00 50.51 ? 538 GLU A C 1 ATOM 4306 O O . GLU A 1 538 ? -27.066 -9.114 -7.689 1.00 51.36 ? 538 GLU A O 1 ATOM 4307 C CB . GLU A 1 538 ? -28.355 -11.929 -8.959 1.00 49.82 ? 538 GLU A CB 1 ATOM 4308 C CG . GLU A 1 538 ? -27.059 -12.272 -9.704 1.00 52.58 ? 538 GLU A CG 1 ATOM 4309 C CD . GLU A 1 538 ? -25.877 -11.386 -9.322 1.00 56.80 ? 538 GLU A CD 1 ATOM 4310 O OE1 . GLU A 1 538 ? -25.372 -10.634 -10.194 1.00 59.82 ? 538 GLU A OE1 1 ATOM 4311 O OE2 . GLU A 1 538 ? -25.449 -11.438 -8.144 1.00 57.10 ? 538 GLU A OE2 1 ATOM 4312 N N . LYS A 1 539 ? -29.307 -9.100 -8.054 1.00 50.70 ? 539 LYS A N 1 ATOM 4313 C CA . LYS A 1 539 ? -29.409 -7.711 -8.454 1.00 50.92 ? 539 LYS A CA 1 ATOM 4314 C C . LYS A 1 539 ? -29.319 -6.815 -7.225 1.00 50.83 ? 539 LYS A C 1 ATOM 4315 O O . LYS A 1 539 ? -28.488 -5.898 -7.198 1.00 50.63 ? 539 LYS A O 1 ATOM 4316 C CB . LYS A 1 539 ? -30.725 -7.481 -9.214 1.00 51.33 ? 539 LYS A CB 1 ATOM 4317 C CG . LYS A 1 539 ? -30.708 -7.952 -10.680 1.00 52.29 ? 539 LYS A CG 1 ATOM 4318 C CD . LYS A 1 539 ? -31.977 -8.760 -11.020 1.00 52.88 ? 539 LYS A CD 1 ATOM 4319 C CE . LYS A 1 539 ? -31.714 -10.288 -11.046 1.00 52.78 ? 539 LYS A CE 1 ATOM 4320 N NZ . LYS A 1 539 ? -31.220 -10.888 -9.763 1.00 49.60 ? 539 LYS A NZ 1 ATOM 4321 N N . GLN A 1 540 ? -30.173 -7.091 -6.227 1.00 50.13 ? 540 GLN A N 1 ATOM 4322 C CA . GLN A 1 540 ? -30.143 -6.421 -4.926 1.00 49.88 ? 540 GLN A CA 1 ATOM 4323 C C . GLN A 1 540 ? -28.705 -6.380 -4.344 1.00 50.71 ? 540 GLN A C 1 ATOM 4324 O O . GLN A 1 540 ? -28.229 -5.316 -3.933 1.00 51.32 ? 540 GLN A O 1 ATOM 4325 C CB . GLN A 1 540 ? -31.169 -7.038 -3.953 1.00 49.26 ? 540 GLN A CB 1 ATOM 4326 C CG . GLN A 1 540 ? -32.631 -6.911 -4.430 1.00 47.53 ? 540 GLN A CG 1 ATOM 4327 C CD . GLN A 1 540 ? -33.717 -7.310 -3.408 1.00 47.32 ? 540 GLN A CD 1 ATOM 4328 O OE1 . GLN A 1 540 ? -33.571 -8.257 -2.633 1.00 46.96 ? 540 GLN A OE1 1 ATOM 4329 N NE2 . GLN A 1 540 ? -34.836 -6.590 -3.440 1.00 46.58 ? 540 GLN A NE2 1 ATOM 4330 N N . ARG A 1 541 ? -27.983 -7.498 -4.389 1.00 50.58 ? 541 ARG A N 1 ATOM 4331 C CA . ARG A 1 541 ? -26.585 -7.509 -3.937 1.00 50.88 ? 541 ARG A CA 1 ATOM 4332 C C . ARG A 1 541 ? -25.624 -6.668 -4.794 1.00 51.45 ? 541 ARG A C 1 ATOM 4333 O O . ARG A 1 541 ? -24.477 -6.409 -4.395 1.00 51.91 ? 541 ARG A O 1 ATOM 4334 C CB . ARG A 1 541 ? -26.048 -8.942 -3.833 1.00 50.44 ? 541 ARG A CB 1 ATOM 4335 C CG . ARG A 1 541 ? -26.705 -9.764 -2.743 1.00 50.45 ? 541 ARG A CG 1 ATOM 4336 C CD . ARG A 1 541 ? -25.973 -11.062 -2.492 1.00 48.99 ? 541 ARG A CD 1 ATOM 4337 N NE . ARG A 1 541 ? -25.802 -11.866 -3.701 1.00 48.03 ? 541 ARG A NE 1 ATOM 4338 C CZ . ARG A 1 541 ? -26.705 -12.716 -4.177 1.00 45.88 ? 541 ARG A CZ 1 ATOM 4339 N NH1 . ARG A 1 541 ? -27.859 -12.875 -3.563 1.00 44.25 ? 541 ARG A NH1 1 ATOM 4340 N NH2 . ARG A 1 541 ? -26.445 -13.410 -5.279 1.00 46.86 ? 541 ARG A NH2 1 ATOM 4341 N N . ASP A 1 542 ? -26.054 -6.265 -5.981 1.00 51.49 ? 542 ASP A N 1 ATOM 4342 C CA . ASP A 1 542 ? -25.170 -5.458 -6.816 1.00 51.64 ? 542 ASP A CA 1 ATOM 4343 C C . ASP A 1 542 ? -25.285 -3.966 -6.535 1.00 50.86 ? 542 ASP A C 1 ATOM 4344 O O . ASP A 1 542 ? -24.292 -3.240 -6.585 1.00 50.73 ? 542 ASP A O 1 ATOM 4345 C CB . ASP A 1 542 ? -25.355 -5.782 -8.291 1.00 52.05 ? 542 ASP A CB 1 ATOM 4346 C CG . ASP A 1 542 ? -24.387 -6.840 -8.752 1.00 53.73 ? 542 ASP A CG 1 ATOM 4347 O OD1 . ASP A 1 542 ? -23.477 -6.483 -9.534 1.00 52.92 ? 542 ASP A OD1 1 ATOM 4348 O OD2 . ASP A 1 542 ? -24.512 -8.010 -8.286 1.00 55.19 ? 542 ASP A OD2 1 ATOM 4349 N N . SER A 1 543 ? -26.499 -3.535 -6.230 1.00 50.15 ? 543 SER A N 1 ATOM 4350 C CA . SER A 1 543 ? -26.725 -2.207 -5.706 1.00 50.40 ? 543 SER A CA 1 ATOM 4351 C C . SER A 1 543 ? -25.983 -2.034 -4.371 1.00 50.10 ? 543 SER A C 1 ATOM 4352 O O . SER A 1 543 ? -25.063 -1.214 -4.260 1.00 49.90 ? 543 SER A O 1 ATOM 4353 C CB . SER A 1 543 ? -28.218 -1.946 -5.548 1.00 50.01 ? 543 SER A CB 1 ATOM 4354 O OG . SER A 1 543 ? -28.840 -2.077 -6.814 1.00 51.11 ? 543 SER A OG 1 ATOM 4355 N N . LEU A 1 544 ? -26.361 -2.841 -3.381 1.00 49.51 ? 544 LEU A N 1 ATOM 4356 C CA . LEU A 1 544 ? -25.695 -2.840 -2.076 1.00 48.48 ? 544 LEU A CA 1 ATOM 4357 C C . LEU A 1 544 ? -24.182 -2.624 -2.161 1.00 48.28 ? 544 LEU A C 1 ATOM 4358 O O . LEU A 1 544 ? -23.636 -1.820 -1.421 1.00 48.15 ? 544 LEU A O 1 ATOM 4359 C CB . LEU A 1 544 ? -26.019 -4.123 -1.324 1.00 47.91 ? 544 LEU A CB 1 ATOM 4360 C CG . LEU A 1 544 ? -27.487 -4.260 -0.933 1.00 47.23 ? 544 LEU A CG 1 ATOM 4361 C CD1 . LEU A 1 544 ? -27.738 -5.618 -0.326 1.00 48.53 ? 544 LEU A CD1 1 ATOM 4362 C CD2 . LEU A 1 544 ? -27.932 -3.163 -0.001 1.00 47.17 ? 544 LEU A CD2 1 ATOM 4363 N N . GLN A 1 545 ? -23.526 -3.291 -3.102 1.00 48.04 ? 545 GLN A N 1 ATOM 4364 C CA . GLN A 1 545 ? -22.077 -3.212 -3.250 1.00 48.14 ? 545 GLN A CA 1 ATOM 4365 C C . GLN A 1 545 ? -21.536 -1.791 -3.485 1.00 47.34 ? 545 GLN A C 1 ATOM 4366 O O . GLN A 1 545 ? -20.315 -1.556 -3.491 1.00 46.93 ? 545 GLN A O 1 ATOM 4367 C CB . GLN A 1 545 ? -21.642 -4.157 -4.374 1.00 48.74 ? 545 GLN A CB 1 ATOM 4368 C CG . GLN A 1 545 ? -20.207 -4.679 -4.250 1.00 52.19 ? 545 GLN A CG 1 ATOM 4369 C CD . GLN A 1 545 ? -19.912 -5.346 -2.894 1.00 56.96 ? 545 GLN A CD 1 ATOM 4370 O OE1 . GLN A 1 545 ? -20.787 -5.998 -2.299 1.00 57.00 ? 545 GLN A OE1 1 ATOM 4371 N NE2 . GLN A 1 545 ? -18.667 -5.187 -2.404 1.00 57.97 ? 545 GLN A NE2 1 ATOM 4372 N N . LYS A 1 546 ? -22.466 -0.859 -3.660 1.00 46.76 ? 546 LYS A N 1 ATOM 4373 C CA . LYS A 1 546 ? -22.190 0.531 -3.981 1.00 46.09 ? 546 LYS A CA 1 ATOM 4374 C C . LYS A 1 546 ? -22.149 1.441 -2.758 1.00 45.21 ? 546 LYS A C 1 ATOM 4375 O O . LYS A 1 546 ? -21.514 2.507 -2.810 1.00 45.42 ? 546 LYS A O 1 ATOM 4376 C CB . LYS A 1 546 ? -23.251 1.058 -4.958 1.00 46.33 ? 546 LYS A CB 1 ATOM 4377 C CG . LYS A 1 546 ? -22.831 1.038 -6.426 1.00 48.37 ? 546 LYS A CG 1 ATOM 4378 C CD . LYS A 1 546 ? -24.021 0.692 -7.348 1.00 50.76 ? 546 LYS A CD 1 ATOM 4379 C CE . LYS A 1 546 ? -23.763 1.101 -8.815 1.00 51.43 ? 546 LYS A CE 1 ATOM 4380 N NZ . LYS A 1 546 ? -22.432 0.692 -9.372 1.00 51.15 ? 546 LYS A NZ 1 ATOM 4381 N N . VAL A 1 547 ? -22.842 1.046 -1.681 1.00 43.75 ? 547 VAL A N 1 ATOM 4382 C CA . VAL A 1 547 ? -22.913 1.850 -0.454 1.00 41.94 ? 547 VAL A CA 1 ATOM 4383 C C . VAL A 1 547 ? -21.679 2.213 0.364 1.00 41.51 ? 547 VAL A C 1 ATOM 4384 O O . VAL A 1 547 ? -20.848 1.358 0.692 1.00 41.11 ? 547 VAL A O 1 ATOM 4385 C CB . VAL A 1 547 ? -23.565 1.104 0.711 1.00 41.75 ? 547 VAL A CB 1 ATOM 4386 C CG1 . VAL A 1 547 ? -25.019 0.762 0.387 1.00 42.93 ? 547 VAL A CG1 1 ATOM 4387 C CG2 . VAL A 1 547 ? -22.784 -0.151 1.094 1.00 40.77 ? 547 VAL A CG2 1 ATOM 4388 N N . SER A 1 548 ? -21.556 3.505 0.639 1.00 40.73 ? 548 SER A N 1 ATOM 4389 C CA . SER A 1 548 ? -20.406 4.054 1.299 1.00 39.70 ? 548 SER A CA 1 ATOM 4390 C C . SER A 1 548 ? -20.948 4.913 2.415 1.00 39.40 ? 548 SER A C 1 ATOM 4391 O O . SER A 1 548 ? -22.040 5.473 2.278 1.00 39.39 ? 548 SER A O 1 ATOM 4392 C CB . SER A 1 548 ? -19.614 4.914 0.333 1.00 39.93 ? 548 SER A CB 1 ATOM 4393 O OG . SER A 1 548 ? -20.285 6.129 0.103 1.00 40.31 ? 548 SER A OG 1 ATOM 4394 N N . PHE A 1 549 ? -20.199 5.021 3.513 1.00 38.50 ? 549 PHE A N 1 ATOM 4395 C CA . PHE A 1 549 ? -20.538 5.979 4.558 1.00 37.66 ? 549 PHE A CA 1 ATOM 4396 C C . PHE A 1 549 ? -20.615 7.424 4.015 1.00 37.90 ? 549 PHE A C 1 ATOM 4397 O O . PHE A 1 549 ? -21.581 8.155 4.326 1.00 37.44 ? 549 PHE A O 1 ATOM 4398 C CB . PHE A 1 549 ? -19.568 5.894 5.750 1.00 37.25 ? 549 PHE A CB 1 ATOM 4399 C CG . PHE A 1 549 ? -20.145 6.444 7.023 1.00 35.51 ? 549 PHE A CG 1 ATOM 4400 C CD1 . PHE A 1 549 ? -20.777 5.622 7.923 1.00 35.43 ? 549 PHE A CD1 1 ATOM 4401 C CD2 . PHE A 1 549 ? -20.102 7.795 7.296 1.00 34.47 ? 549 PHE A CD2 1 ATOM 4402 C CE1 . PHE A 1 549 ? -21.347 6.145 9.103 1.00 34.79 ? 549 PHE A CE1 1 ATOM 4403 C CE2 . PHE A 1 549 ? -20.670 8.316 8.472 1.00 34.56 ? 549 PHE A CE2 1 ATOM 4404 C CZ . PHE A 1 549 ? -21.286 7.485 9.368 1.00 32.51 ? 549 PHE A CZ 1 ATOM 4405 N N . SER A 1 550 ? -19.623 7.813 3.202 1.00 37.89 ? 550 SER A N 1 ATOM 4406 C CA . SER A 1 550 ? -19.658 9.080 2.462 1.00 39.04 ? 550 SER A CA 1 ATOM 4407 C C . SER A 1 550 ? -21.053 9.338 1.895 1.00 39.33 ? 550 SER A C 1 ATOM 4408 O O . SER A 1 550 ? -21.706 10.321 2.254 1.00 40.19 ? 550 SER A O 1 ATOM 4409 C CB . SER A 1 550 ? -18.636 9.088 1.323 1.00 39.59 ? 550 SER A CB 1 ATOM 4410 O OG . SER A 1 550 ? -17.529 8.231 1.569 1.00 40.50 ? 550 SER A OG 1 ATOM 4411 N N . ARG A 1 551 ? -21.536 8.422 1.059 1.00 39.58 ? 551 ARG A N 1 ATOM 4412 C CA . ARG A 1 551 ? -22.932 8.461 0.569 1.00 39.39 ? 551 ARG A CA 1 ATOM 4413 C C . ARG A 1 551 ? -24.009 8.645 1.655 1.00 39.07 ? 551 ARG A C 1 ATOM 4414 O O . ARG A 1 551 ? -24.940 9.436 1.478 1.00 39.41 ? 551 ARG A O 1 ATOM 4415 C CB . ARG A 1 551 ? -23.235 7.206 -0.269 1.00 39.42 ? 551 ARG A CB 1 ATOM 4416 C CG . ARG A 1 551 ? -24.566 7.218 -0.983 1.00 40.02 ? 551 ARG A CG 1 ATOM 4417 C CD . ARG A 1 551 ? -24.463 8.054 -2.257 1.00 42.03 ? 551 ARG A CD 1 ATOM 4418 N NE . ARG A 1 551 ? -25.265 9.273 -2.245 1.00 40.90 ? 551 ARG A NE 1 ATOM 4419 C CZ . ARG A 1 551 ? -24.988 10.350 -2.966 1.00 39.45 ? 551 ARG A CZ 1 ATOM 4420 N NH1 . ARG A 1 551 ? -23.907 10.385 -3.741 1.00 39.57 ? 551 ARG A NH1 1 ATOM 4421 N NH2 . ARG A 1 551 ? -25.787 11.398 -2.890 1.00 37.84 ? 551 ARG A NH2 1 ATOM 4422 N N . LEU A 1 552 ? -23.909 7.910 2.758 1.00 38.79 ? 552 LEU A N 1 ATOM 4423 C CA . LEU A 1 552 ? -24.931 7.992 3.815 1.00 39.35 ? 552 LEU A CA 1 ATOM 4424 C C . LEU A 1 552 ? -25.068 9.412 4.364 1.00 39.35 ? 552 LEU A C 1 ATOM 4425 O O . LEU A 1 552 ? -26.171 9.866 4.593 1.00 39.18 ? 552 LEU A O 1 ATOM 4426 C CB . LEU A 1 552 ? -24.643 7.004 4.949 1.00 39.51 ? 552 LEU A CB 1 ATOM 4427 C CG . LEU A 1 552 ? -25.349 7.166 6.306 1.00 40.19 ? 552 LEU A CG 1 ATOM 4428 C CD1 . LEU A 1 552 ? -26.579 6.252 6.425 1.00 42.22 ? 552 LEU A CD1 1 ATOM 4429 C CD2 . LEU A 1 552 ? -24.392 6.869 7.431 1.00 37.87 ? 552 LEU A CD2 1 ATOM 4430 N N . ILE A 1 553 ? -23.939 10.092 4.573 1.00 40.03 ? 553 ILE A N 1 ATOM 4431 C CA . ILE A 1 553 ? -23.912 11.526 4.931 1.00 40.64 ? 553 ILE A CA 1 ATOM 4432 C C . ILE A 1 553 ? -24.611 12.341 3.835 1.00 41.40 ? 553 ILE A C 1 ATOM 4433 O O . ILE A 1 553 ? -25.701 12.874 4.075 1.00 41.86 ? 553 ILE A O 1 ATOM 4434 C CB . ILE A 1 553 ? -22.456 12.037 5.163 1.00 40.95 ? 553 ILE A CB 1 ATOM 4435 C CG1 . ILE A 1 553 ? -21.813 11.323 6.364 1.00 39.42 ? 553 ILE A CG1 1 ATOM 4436 C CG2 . ILE A 1 553 ? -22.409 13.560 5.345 1.00 40.51 ? 553 ILE A CG2 1 ATOM 4437 C CD1 . ILE A 1 553 ? -20.329 11.279 6.281 1.00 36.92 ? 553 ILE A CD1 1 ATOM 4438 N N . CYS A 1 554 ? -24.007 12.383 2.642 1.00 41.36 ? 554 CYS A N 1 ATOM 4439 C CA . CYS A 1 554 ? -24.592 13.024 1.458 1.00 42.21 ? 554 CYS A CA 1 ATOM 4440 C C . CYS A 1 554 ? -26.112 12.986 1.432 1.00 41.90 ? 554 CYS A C 1 ATOM 4441 O O . CYS A 1 554 ? -26.759 14.032 1.387 1.00 42.05 ? 554 CYS A O 1 ATOM 4442 C CB . CYS A 1 554 ? -24.092 12.371 0.172 1.00 42.13 ? 554 CYS A CB 1 ATOM 4443 S SG . CYS A 1 554 ? -22.407 12.663 -0.231 1.00 46.03 ? 554 CYS A SG 1 ATOM 4444 N N . ASP A 1 555 ? -26.688 11.791 1.451 1.00 41.66 ? 555 ASP A N 1 ATOM 4445 C CA . ASP A 1 555 ? -28.139 11.695 1.349 1.00 41.70 ? 555 ASP A CA 1 ATOM 4446 C C . ASP A 1 555 ? -28.851 11.911 2.703 1.00 41.56 ? 555 ASP A C 1 ATOM 4447 O O . ASP A 1 555 ? -30.071 11.783 2.783 1.00 41.61 ? 555 ASP A O 1 ATOM 4448 C CB . ASP A 1 555 ? -28.581 10.364 0.691 1.00 41.88 ? 555 ASP A CB 1 ATOM 4449 C CG . ASP A 1 555 ? -27.727 9.966 -0.561 1.00 42.77 ? 555 ASP A CG 1 ATOM 4450 O OD1 . ASP A 1 555 ? -27.479 10.807 -1.459 1.00 40.84 ? 555 ASP A OD1 1 ATOM 4451 O OD2 . ASP A 1 555 ? -27.320 8.775 -0.655 1.00 41.90 ? 555 ASP A OD2 1 ATOM 4452 N N . ASN A 1 556 ? -28.124 12.243 3.774 1.00 41.47 ? 556 ASN A N 1 ATOM 4453 C CA . ASN A 1 556 ? -28.813 12.401 5.085 1.00 41.89 ? 556 ASN A CA 1 ATOM 4454 C C . ASN A 1 556 ? -28.431 13.659 5.877 1.00 42.37 ? 556 ASN A C 1 ATOM 4455 O O . ASN A 1 556 ? -28.887 13.877 7.019 1.00 42.18 ? 556 ASN A O 1 ATOM 4456 C CB . ASN A 1 556 ? -28.724 11.124 5.963 1.00 41.25 ? 556 ASN A CB 1 ATOM 4457 C CG . ASN A 1 556 ? -29.407 9.913 5.330 1.00 41.16 ? 556 ASN A CG 1 ATOM 4458 O OD1 . ASN A 1 556 ? -30.573 9.634 5.614 1.00 42.31 ? 556 ASN A OD1 1 ATOM 4459 N ND2 . ASN A 1 556 ? -28.684 9.189 4.465 1.00 37.39 ? 556 ASN A ND2 1 ATOM 4460 N N . THR A 1 557 ? -27.606 14.498 5.261 1.00 43.19 ? 557 THR A N 1 ATOM 4461 C CA . THR A 1 557 ? -27.227 15.782 5.859 1.00 43.93 ? 557 THR A CA 1 ATOM 4462 C C . THR A 1 557 ? -27.057 16.843 4.777 1.00 44.44 ? 557 THR A C 1 ATOM 4463 O O . THR A 1 557 ? -27.006 16.538 3.585 1.00 44.84 ? 557 THR A O 1 ATOM 4464 C CB . THR A 1 557 ? -25.907 15.675 6.633 1.00 43.75 ? 557 THR A CB 1 ATOM 4465 O OG1 . THR A 1 557 ? -24.856 15.366 5.714 1.00 43.60 ? 557 THR A OG1 1 ATOM 4466 C CG2 . THR A 1 557 ? -25.982 14.578 7.690 1.00 43.88 ? 557 THR A CG2 1 ATOM 4467 N N . HIS A 1 558 ? -26.952 18.095 5.194 1.00 44.61 ? 558 HIS A N 1 ATOM 4468 C CA . HIS A 1 558 ? -26.789 19.168 4.242 1.00 44.35 ? 558 HIS A CA 1 ATOM 4469 C C . HIS A 1 558 ? -25.316 19.367 3.886 1.00 44.61 ? 558 HIS A C 1 ATOM 4470 O O . HIS A 1 558 ? -24.943 20.388 3.287 1.00 45.23 ? 558 HIS A O 1 ATOM 4471 C CB . HIS A 1 558 ? -27.486 20.441 4.731 1.00 43.87 ? 558 HIS A CB 1 ATOM 4472 C CG . HIS A 1 558 ? -28.985 20.325 4.786 1.00 43.66 ? 558 HIS A CG 1 ATOM 4473 N ND1 . HIS A 1 558 ? -29.737 20.804 5.841 1.00 43.49 ? 558 HIS A ND1 1 ATOM 4474 C CD2 . HIS A 1 558 ? -29.870 19.789 3.910 1.00 43.52 ? 558 HIS A CD2 1 ATOM 4475 C CE1 . HIS A 1 558 ? -31.018 20.566 5.615 1.00 43.16 ? 558 HIS A CE1 1 ATOM 4476 N NE2 . HIS A 1 558 ? -31.127 19.946 4.451 1.00 44.94 ? 558 HIS A NE2 1 ATOM 4477 N N . ILE A 1 559 ? -24.485 18.386 4.235 1.00 43.83 ? 559 ILE A N 1 ATOM 4478 C CA . ILE A 1 559 ? -23.116 18.343 3.743 1.00 43.41 ? 559 ILE A CA 1 ATOM 4479 C C . ILE A 1 559 ? -23.173 17.873 2.295 1.00 44.07 ? 559 ILE A C 1 ATOM 4480 O O . ILE A 1 559 ? -24.039 17.071 1.945 1.00 43.92 ? 559 ILE A O 1 ATOM 4481 C CB . ILE A 1 559 ? -22.204 17.445 4.631 1.00 43.17 ? 559 ILE A CB 1 ATOM 4482 C CG1 . ILE A 1 559 ? -22.135 18.024 6.053 1.00 42.56 ? 559 ILE A CG1 1 ATOM 4483 C CG2 . ILE A 1 559 ? -20.771 17.326 4.048 1.00 42.25 ? 559 ILE A CG2 1 ATOM 4484 C CD1 . ILE A 1 559 ? -21.745 17.029 7.155 1.00 40.27 ? 559 ILE A CD1 1 ATOM 4485 N N . THR A 1 560 ? -22.276 18.402 1.454 1.00 44.79 ? 560 THR A N 1 ATOM 4486 C CA . THR A 1 560 ? -22.268 18.108 0.017 1.00 45.32 ? 560 THR A CA 1 ATOM 4487 C C . THR A 1 560 ? -20.845 17.934 -0.478 1.00 46.07 ? 560 THR A C 1 ATOM 4488 O O . THR A 1 560 ? -20.609 17.769 -1.681 1.00 46.54 ? 560 THR A O 1 ATOM 4489 C CB . THR A 1 560 ? -22.960 19.220 -0.850 1.00 45.38 ? 560 THR A CB 1 ATOM 4490 O OG1 . THR A 1 560 ? -22.092 20.350 -0.984 1.00 44.84 ? 560 THR A OG1 1 ATOM 4491 C CG2 . THR A 1 560 ? -24.333 19.660 -0.272 1.00 45.31 ? 560 THR A CG2 1 ATOM 4492 N N . LYS A 1 561 ? -19.899 18.022 0.450 1.00 46.73 ? 561 LYS A N 1 ATOM 4493 C CA . LYS A 1 561 ? -18.497 17.749 0.177 1.00 47.04 ? 561 LYS A CA 1 ATOM 4494 C C . LYS A 1 561 ? -18.054 16.621 1.116 1.00 47.37 ? 561 LYS A C 1 ATOM 4495 O O . LYS A 1 561 ? -18.182 16.771 2.340 1.00 48.07 ? 561 LYS A O 1 ATOM 4496 C CB . LYS A 1 561 ? -17.656 19.014 0.391 1.00 47.04 ? 561 LYS A CB 1 ATOM 4497 C CG . LYS A 1 561 ? -17.047 19.685 -0.890 1.00 46.87 ? 561 LYS A CG 1 ATOM 4498 C CD . LYS A 1 561 ? -15.870 18.843 -1.512 1.00 47.25 ? 561 LYS A CD 1 ATOM 4499 C CE . LYS A 1 561 ? -14.622 19.676 -1.976 1.00 45.45 ? 561 LYS A CE 1 ATOM 4500 N NZ . LYS A 1 561 ? -14.765 20.477 -3.238 1.00 43.84 ? 561 LYS A NZ 1 ATOM 4501 N N . VAL A 1 562 ? -17.581 15.498 0.539 1.00 46.89 ? 562 VAL A N 1 ATOM 4502 C CA . VAL A 1 562 ? -17.169 14.276 1.275 1.00 45.90 ? 562 VAL A CA 1 ATOM 4503 C C . VAL A 1 562 ? -15.978 13.578 0.617 1.00 46.06 ? 562 VAL A C 1 ATOM 4504 O O . VAL A 1 562 ? -15.834 13.620 -0.605 1.00 46.54 ? 562 VAL A O 1 ATOM 4505 C CB . VAL A 1 562 ? -18.288 13.205 1.374 1.00 45.76 ? 562 VAL A CB 1 ATOM 4506 C CG1 . VAL A 1 562 ? -19.503 13.710 2.155 1.00 45.53 ? 562 VAL A CG1 1 ATOM 4507 C CG2 . VAL A 1 562 ? -18.694 12.699 -0.007 1.00 45.24 ? 562 VAL A CG2 1 ATOM 4508 N N . PRO A 1 563 ? -15.124 12.905 1.420 1.00 45.65 ? 563 PRO A N 1 ATOM 4509 C CA . PRO A 1 563 ? -14.080 12.079 0.827 1.00 45.10 ? 563 PRO A CA 1 ATOM 4510 C C . PRO A 1 563 ? -14.640 10.772 0.280 1.00 44.38 ? 563 PRO A C 1 ATOM 4511 O O . PRO A 1 563 ? -15.778 10.426 0.565 1.00 44.57 ? 563 PRO A O 1 ATOM 4512 C CB . PRO A 1 563 ? -13.174 11.781 2.012 1.00 45.42 ? 563 PRO A CB 1 ATOM 4513 C CG . PRO A 1 563 ? -14.120 11.724 3.177 1.00 45.92 ? 563 PRO A CG 1 ATOM 4514 C CD . PRO A 1 563 ? -15.115 12.823 2.894 1.00 45.64 ? 563 PRO A CD 1 ATOM 4515 N N . LEU A 1 564 ? -13.841 10.061 -0.500 1.00 44.04 ? 564 LEU A N 1 ATOM 4516 C CA . LEU A 1 564 ? -14.197 8.725 -0.976 1.00 43.91 ? 564 LEU A CA 1 ATOM 4517 C C . LEU A 1 564 ? -14.113 7.693 0.152 1.00 43.37 ? 564 LEU A C 1 ATOM 4518 O O . LEU A 1 564 ? -15.053 6.913 0.380 1.00 42.54 ? 564 LEU A O 1 ATOM 4519 C CB . LEU A 1 564 ? -13.236 8.289 -2.086 1.00 44.19 ? 564 LEU A CB 1 ATOM 4520 C CG . LEU A 1 564 ? -13.096 9.207 -3.294 1.00 45.56 ? 564 LEU A CG 1 ATOM 4521 C CD1 . LEU A 1 564 ? -11.867 8.797 -4.137 1.00 45.90 ? 564 LEU A CD1 1 ATOM 4522 C CD2 . LEU A 1 564 ? -14.402 9.198 -4.091 1.00 45.63 ? 564 LEU A CD2 1 ATOM 4523 N N . HIS A 1 565 ? -12.965 7.714 0.834 1.00 42.87 ? 565 HIS A N 1 ATOM 4524 C CA . HIS A 1 565 ? -12.580 6.734 1.838 1.00 42.27 ? 565 HIS A CA 1 ATOM 4525 C C . HIS A 1 565 ? -12.701 7.351 3.221 1.00 41.42 ? 565 HIS A C 1 ATOM 4526 O O . HIS A 1 565 ? -11.698 7.717 3.841 1.00 41.56 ? 565 HIS A O 1 ATOM 4527 C CB . HIS A 1 565 ? -11.134 6.272 1.611 1.00 42.53 ? 565 HIS A CB 1 ATOM 4528 C CG . HIS A 1 565 ? -10.812 5.938 0.187 1.00 44.67 ? 565 HIS A CG 1 ATOM 4529 N ND1 . HIS A 1 565 ? -11.515 5.000 -0.539 1.00 46.48 ? 565 HIS A ND1 1 ATOM 4530 C CD2 . HIS A 1 565 ? -9.851 6.414 -0.643 1.00 46.02 ? 565 HIS A CD2 1 ATOM 4531 C CE1 . HIS A 1 565 ? -11.003 4.916 -1.756 1.00 46.66 ? 565 HIS A CE1 1 ATOM 4532 N NE2 . HIS A 1 565 ? -9.991 5.763 -1.843 1.00 45.91 ? 565 HIS A NE2 1 ATOM 4533 N N . ALA A 1 566 ? -13.940 7.428 3.695 1.00 40.62 ? 566 ALA A N 1 ATOM 4534 C CA . ALA A 1 566 ? -14.315 8.018 4.979 1.00 39.74 ? 566 ALA A CA 1 ATOM 4535 C C . ALA A 1 566 ? -13.459 7.674 6.216 1.00 39.90 ? 566 ALA A C 1 ATOM 4536 O O . ALA A 1 566 ? -13.392 8.467 7.173 1.00 39.05 ? 566 ALA A O 1 ATOM 4537 C CB . ALA A 1 566 ? -15.778 7.724 5.255 1.00 39.49 ? 566 ALA A CB 1 ATOM 4538 N N . PHE A 1 567 ? -12.801 6.518 6.202 1.00 39.50 ? 567 PHE A N 1 ATOM 4539 C CA . PHE A 1 567 ? -12.144 6.038 7.405 1.00 40.42 ? 567 PHE A CA 1 ATOM 4540 C C . PHE A 1 567 ? -10.696 6.496 7.600 1.00 41.02 ? 567 PHE A C 1 ATOM 4541 O O . PHE A 1 567 ? -10.209 6.593 8.720 1.00 40.68 ? 567 PHE A O 1 ATOM 4542 C CB . PHE A 1 567 ? -12.268 4.521 7.507 1.00 40.31 ? 567 PHE A CB 1 ATOM 4543 C CG . PHE A 1 567 ? -13.651 4.056 7.870 1.00 41.29 ? 567 PHE A CG 1 ATOM 4544 C CD1 . PHE A 1 567 ? -14.023 3.906 9.197 1.00 40.68 ? 567 PHE A CD1 1 ATOM 4545 C CD2 . PHE A 1 567 ? -14.594 3.781 6.886 1.00 42.47 ? 567 PHE A CD2 1 ATOM 4546 C CE1 . PHE A 1 567 ? -15.288 3.471 9.536 1.00 40.05 ? 567 PHE A CE1 1 ATOM 4547 C CE2 . PHE A 1 567 ? -15.883 3.352 7.236 1.00 41.42 ? 567 PHE A CE2 1 ATOM 4548 C CZ . PHE A 1 567 ? -16.220 3.192 8.567 1.00 39.33 ? 567 PHE A CZ 1 ATOM 4549 N N . GLN A 1 568 ? -10.012 6.793 6.512 1.00 42.26 ? 568 GLN A N 1 ATOM 4550 C CA . GLN A 1 568 ? -8.661 7.284 6.610 1.00 43.51 ? 568 GLN A CA 1 ATOM 4551 C C . GLN A 1 568 ? -8.655 8.807 6.831 1.00 43.93 ? 568 GLN A C 1 ATOM 4552 O O . GLN A 1 568 ? -9.701 9.466 6.741 1.00 42.86 ? 568 GLN A O 1 ATOM 4553 C CB . GLN A 1 568 ? -7.881 6.887 5.361 1.00 44.06 ? 568 GLN A CB 1 ATOM 4554 C CG . GLN A 1 568 ? -8.316 7.590 4.108 1.00 47.40 ? 568 GLN A CG 1 ATOM 4555 C CD . GLN A 1 568 ? -7.916 6.825 2.852 1.00 52.53 ? 568 GLN A CD 1 ATOM 4556 O OE1 . GLN A 1 568 ? -8.084 5.600 2.774 1.00 52.74 ? 568 GLN A OE1 1 ATOM 4557 N NE2 . GLN A 1 568 ? -7.392 7.550 1.854 1.00 53.16 ? 568 GLN A NE2 1 ATOM 4558 N N . ALA A 1 569 ? -7.475 9.348 7.139 1.00 44.77 ? 569 ALA A N 1 ATOM 4559 C CA . ALA A 1 569 ? -7.308 10.778 7.431 1.00 45.72 ? 569 ALA A CA 1 ATOM 4560 C C . ALA A 1 569 ? -7.492 11.626 6.173 1.00 46.56 ? 569 ALA A C 1 ATOM 4561 O O . ALA A 1 569 ? -6.688 11.544 5.233 1.00 47.06 ? 569 ALA A O 1 ATOM 4562 C CB . ALA A 1 569 ? -5.952 11.034 8.055 1.00 45.33 ? 569 ALA A CB 1 ATOM 4563 N N . ASN A 1 570 ? -8.560 12.428 6.159 1.00 47.22 ? 570 ASN A N 1 ATOM 4564 C CA . ASN A 1 570 ? -8.966 13.189 4.971 1.00 47.44 ? 570 ASN A CA 1 ATOM 4565 C C . ASN A 1 570 ? -8.962 14.713 5.178 1.00 48.19 ? 570 ASN A C 1 ATOM 4566 O O . ASN A 1 570 ? -9.692 15.238 6.039 1.00 48.63 ? 570 ASN A O 1 ATOM 4567 C CB . ASN A 1 570 ? -10.345 12.717 4.494 1.00 46.75 ? 570 ASN A CB 1 ATOM 4568 C CG . ASN A 1 570 ? -10.301 11.362 3.860 1.00 46.12 ? 570 ASN A CG 1 ATOM 4569 O OD1 . ASN A 1 570 ? -11.146 10.515 4.130 1.00 45.14 ? 570 ASN A OD1 1 ATOM 4570 N ND2 . ASN A 1 570 ? -9.305 11.135 3.014 1.00 45.47 ? 570 ASN A ND2 1 ATOM 4571 N N . ASN A 1 571 ? -8.154 15.407 4.375 1.00 48.63 ? 571 ASN A N 1 ATOM 4572 C CA . ASN A 1 571 ? -7.955 16.852 4.502 1.00 48.81 ? 571 ASN A CA 1 ATOM 4573 C C . ASN A 1 571 ? -8.560 17.615 3.369 1.00 49.48 ? 571 ASN A C 1 ATOM 4574 O O . ASN A 1 571 ? -8.373 17.283 2.197 1.00 48.99 ? 571 ASN A O 1 ATOM 4575 C CB . ASN A 1 571 ? -6.474 17.206 4.577 1.00 48.67 ? 571 ASN A CB 1 ATOM 4576 C CG . ASN A 1 571 ? -5.803 16.633 5.799 1.00 47.80 ? 571 ASN A CG 1 ATOM 4577 O OD1 . ASN A 1 571 ? -6.254 16.833 6.932 1.00 45.59 ? 571 ASN A OD1 1 ATOM 4578 N ND2 . ASN A 1 571 ? -4.715 15.918 5.578 1.00 46.32 ? 571 ASN A ND2 1 ATOM 4579 N N . TYR A 1 572 ? -9.280 18.657 3.754 1.00 50.74 ? 572 TYR A N 1 ATOM 4580 C CA . TYR A 1 572 ? -9.996 19.550 2.853 1.00 51.64 ? 572 TYR A CA 1 ATOM 4581 C C . TYR A 1 572 ? -9.033 20.560 2.210 1.00 51.70 ? 572 TYR A C 1 ATOM 4582 O O . TYR A 1 572 ? -8.176 21.129 2.892 1.00 51.41 ? 572 TYR A O 1 ATOM 4583 C CB . TYR A 1 572 ? -11.051 20.280 3.665 1.00 51.82 ? 572 TYR A CB 1 ATOM 4584 C CG . TYR A 1 572 ? -12.082 21.015 2.875 1.00 53.67 ? 572 TYR A CG 1 ATOM 4585 C CD1 . TYR A 1 572 ? -13.277 20.385 2.511 1.00 55.20 ? 572 TYR A CD1 1 ATOM 4586 C CD2 . TYR A 1 572 ? -11.892 22.359 2.515 1.00 55.78 ? 572 TYR A CD2 1 ATOM 4587 C CE1 . TYR A 1 572 ? -14.259 21.064 1.789 1.00 56.94 ? 572 TYR A CE1 1 ATOM 4588 C CE2 . TYR A 1 572 ? -12.866 23.054 1.784 1.00 56.21 ? 572 TYR A CE2 1 ATOM 4589 C CZ . TYR A 1 572 ? -14.043 22.399 1.432 1.00 57.21 ? 572 TYR A CZ 1 ATOM 4590 O OH . TYR A 1 572 ? -15.013 23.056 0.731 1.00 57.91 ? 572 TYR A OH 1 ATOM 4591 N N . PRO A 1 573 ? -9.156 20.767 0.890 1.00 51.89 ? 573 PRO A N 1 ATOM 4592 C CA . PRO A 1 573 ? -10.100 20.068 0.038 1.00 52.01 ? 573 PRO A CA 1 ATOM 4593 C C . PRO A 1 573 ? -9.506 18.953 -0.839 1.00 52.17 ? 573 PRO A C 1 ATOM 4594 O O . PRO A 1 573 ? -10.259 18.313 -1.583 1.00 51.94 ? 573 PRO A O 1 ATOM 4595 C CB . PRO A 1 573 ? -10.671 21.196 -0.828 1.00 52.52 ? 573 PRO A CB 1 ATOM 4596 C CG . PRO A 1 573 ? -9.615 22.345 -0.766 1.00 52.39 ? 573 PRO A CG 1 ATOM 4597 C CD . PRO A 1 573 ? -8.529 21.899 0.184 1.00 52.13 ? 573 PRO A CD 1 ATOM 4598 N N . HIS A 1 574 ? -8.196 18.699 -0.740 1.00 52.31 ? 574 HIS A N 1 ATOM 4599 C CA . HIS A 1 574 ? -7.549 17.712 -1.623 1.00 52.70 ? 574 HIS A CA 1 ATOM 4600 C C . HIS A 1 574 ? -8.063 16.272 -1.534 1.00 52.42 ? 574 HIS A C 1 ATOM 4601 O O . HIS A 1 574 ? -7.733 15.456 -2.397 1.00 52.53 ? 574 HIS A O 1 ATOM 4602 C CB . HIS A 1 574 ? -6.016 17.715 -1.516 1.00 53.40 ? 574 HIS A CB 1 ATOM 4603 C CG . HIS A 1 574 ? -5.364 16.564 -2.239 1.00 55.57 ? 574 HIS A CG 1 ATOM 4604 N ND1 . HIS A 1 574 ? -5.609 16.281 -3.571 1.00 57.48 ? 574 HIS A ND1 1 ATOM 4605 C CD2 . HIS A 1 574 ? -4.512 15.604 -1.805 1.00 55.91 ? 574 HIS A CD2 1 ATOM 4606 C CE1 . HIS A 1 574 ? -4.929 15.204 -3.925 1.00 57.49 ? 574 HIS A CE1 1 ATOM 4607 N NE2 . HIS A 1 574 ? -4.252 14.777 -2.874 1.00 56.84 ? 574 HIS A NE2 1 ATOM 4608 N N . ASP A 1 575 ? -8.856 15.941 -0.514 1.00 52.11 ? 575 ASP A N 1 ATOM 4609 C CA . ASP A 1 575 ? -9.415 14.581 -0.422 1.00 50.97 ? 575 ASP A CA 1 ATOM 4610 C C . ASP A 1 575 ? -10.938 14.527 -0.577 1.00 50.32 ? 575 ASP A C 1 ATOM 4611 O O . ASP A 1 575 ? -11.516 13.440 -0.588 1.00 50.14 ? 575 ASP A O 1 ATOM 4612 C CB . ASP A 1 575 ? -8.977 13.879 0.858 1.00 50.79 ? 575 ASP A CB 1 ATOM 4613 C CG . ASP A 1 575 ? -7.468 13.773 0.988 1.00 52.02 ? 575 ASP A CG 1 ATOM 4614 O OD1 . ASP A 1 575 ? -6.795 13.238 0.074 1.00 52.28 ? 575 ASP A OD1 1 ATOM 4615 O OD2 . ASP A 1 575 ? -6.950 14.219 2.032 1.00 53.64 ? 575 ASP A OD2 1 ATOM 4616 N N . PHE A 1 576 ? -11.573 15.688 -0.740 1.00 49.59 ? 576 PHE A N 1 ATOM 4617 C CA . PHE A 1 576 ? -13.043 15.769 -0.848 1.00 49.32 ? 576 PHE A CA 1 ATOM 4618 C C . PHE A 1 576 ? -13.589 15.917 -2.286 1.00 49.34 ? 576 PHE A C 1 ATOM 4619 O O . PHE A 1 576 ? -12.867 16.327 -3.201 1.00 48.66 ? 576 PHE A O 1 ATOM 4620 C CB . PHE A 1 576 ? -13.578 16.892 0.062 1.00 49.23 ? 576 PHE A CB 1 ATOM 4621 C CG . PHE A 1 576 ? -13.455 16.594 1.531 1.00 48.19 ? 576 PHE A CG 1 ATOM 4622 C CD1 . PHE A 1 576 ? -12.204 16.370 2.115 1.00 46.64 ? 576 PHE A CD1 1 ATOM 4623 C CD2 . PHE A 1 576 ? -14.588 16.541 2.336 1.00 47.32 ? 576 PHE A CD2 1 ATOM 4624 C CE1 . PHE A 1 576 ? -12.094 16.083 3.460 1.00 46.04 ? 576 PHE A CE1 1 ATOM 4625 C CE2 . PHE A 1 576 ? -14.482 16.254 3.684 1.00 46.43 ? 576 PHE A CE2 1 ATOM 4626 C CZ . PHE A 1 576 ? -13.241 16.027 4.250 1.00 45.39 ? 576 PHE A CZ 1 ATOM 4627 N N . VAL A 1 577 ? -14.869 15.567 -2.448 1.00 49.50 ? 577 VAL A N 1 ATOM 4628 C CA . VAL A 1 577 ? -15.593 15.566 -3.727 1.00 49.82 ? 577 VAL A CA 1 ATOM 4629 C C . VAL A 1 577 ? -17.082 15.884 -3.461 1.00 50.57 ? 577 VAL A C 1 ATOM 4630 O O . VAL A 1 577 ? -17.530 15.786 -2.314 1.00 50.78 ? 577 VAL A O 1 ATOM 4631 C CB . VAL A 1 577 ? -15.462 14.178 -4.495 1.00 49.97 ? 577 VAL A CB 1 ATOM 4632 C CG1 . VAL A 1 577 ? -13.999 13.773 -4.723 1.00 49.17 ? 577 VAL A CG1 1 ATOM 4633 C CG2 . VAL A 1 577 ? -16.215 13.060 -3.788 1.00 49.60 ? 577 VAL A CG2 1 ATOM 4634 N N . ASP A 1 578 ? -17.852 16.257 -4.491 1.00 50.97 ? 578 ASP A N 1 ATOM 4635 C CA . ASP A 1 578 ? -19.278 16.594 -4.284 1.00 51.70 ? 578 ASP A CA 1 ATOM 4636 C C . ASP A 1 578 ? -20.136 15.352 -4.207 1.00 51.75 ? 578 ASP A C 1 ATOM 4637 O O . ASP A 1 578 ? -19.877 14.358 -4.888 1.00 52.24 ? 578 ASP A O 1 ATOM 4638 C CB . ASP A 1 578 ? -19.856 17.501 -5.399 1.00 52.02 ? 578 ASP A CB 1 ATOM 4639 C CG . ASP A 1 578 ? -20.958 18.458 -4.888 1.00 53.03 ? 578 ASP A CG 1 ATOM 4640 O OD1 . ASP A 1 578 ? -22.186 18.211 -5.132 1.00 50.79 ? 578 ASP A OD1 1 ATOM 4641 O OD2 . ASP A 1 578 ? -20.574 19.474 -4.239 1.00 53.72 ? 578 ASP A OD2 1 ATOM 4642 N N . CYS A 1 579 ? -21.180 15.449 -3.398 1.00 51.74 ? 579 CYS A N 1 ATOM 4643 C CA . CYS A 1 579 ? -22.206 14.437 -3.270 1.00 51.74 ? 579 CYS A CA 1 ATOM 4644 C C . CYS A 1 579 ? -22.575 13.881 -4.654 1.00 52.52 ? 579 CYS A C 1 ATOM 4645 O O . CYS A 1 579 ? -22.901 12.684 -4.819 1.00 52.81 ? 579 CYS A O 1 ATOM 4646 C CB . CYS A 1 579 ? -23.155 14.875 -2.159 1.00 51.50 ? 579 CYS A CB 1 ATOM 4647 S SG . CYS A 1 579 ? -22.367 14.680 -0.529 1.00 50.84 ? 579 CYS A SG 1 ATOM 4648 N N . SER A 1 580 ? -22.528 14.785 -5.633 1.00 52.65 ? 580 SER A N 1 ATOM 4649 C CA . SER A 1 580 ? -22.750 14.493 -7.044 1.00 52.43 ? 580 SER A CA 1 ATOM 4650 C C . SER A 1 580 ? -22.055 13.272 -7.605 1.00 52.46 ? 580 SER A C 1 ATOM 4651 O O . SER A 1 580 ? -22.706 12.399 -8.167 1.00 52.71 ? 580 SER A O 1 ATOM 4652 C CB . SER A 1 580 ? -22.363 15.713 -7.906 1.00 52.33 ? 580 SER A CB 1 ATOM 4653 O OG . SER A 1 580 ? -23.374 16.704 -7.966 1.00 52.03 ? 580 SER A OG 1 ATOM 4654 N N . THR A 1 581 ? -20.733 13.220 -7.429 1.00 52.38 ? 581 THR A N 1 ATOM 4655 C CA . THR A 1 581 ? -19.874 12.253 -8.110 1.00 52.65 ? 581 THR A CA 1 ATOM 4656 C C . THR A 1 581 ? -19.744 10.922 -7.367 1.00 52.67 ? 581 THR A C 1 ATOM 4657 O O . THR A 1 581 ? -18.799 10.158 -7.604 1.00 52.83 ? 581 THR A O 1 ATOM 4658 C CB . THR A 1 581 ? -18.449 12.819 -8.312 1.00 52.94 ? 581 THR A CB 1 ATOM 4659 O OG1 . THR A 1 581 ? -17.807 12.980 -7.035 1.00 52.36 ? 581 THR A OG1 1 ATOM 4660 C CG2 . THR A 1 581 ? -18.495 14.160 -9.066 1.00 52.83 ? 581 THR A CG2 1 ATOM 4661 N N . VAL A 1 582 ? -20.694 10.653 -6.477 1.00 52.33 ? 582 VAL A N 1 ATOM 4662 C CA . VAL A 1 582 ? -20.598 9.527 -5.571 1.00 52.08 ? 582 VAL A CA 1 ATOM 4663 C C . VAL A 1 582 ? -21.762 8.558 -5.751 1.00 52.51 ? 582 VAL A C 1 ATOM 4664 O O . VAL A 1 582 ? -22.910 8.866 -5.401 1.00 52.04 ? 582 VAL A O 1 ATOM 4665 C CB . VAL A 1 582 ? -20.519 9.998 -4.111 1.00 51.91 ? 582 VAL A CB 1 ATOM 4666 C CG1 . VAL A 1 582 ? -20.326 8.817 -3.182 1.00 51.63 ? 582 VAL A CG1 1 ATOM 4667 C CG2 . VAL A 1 582 ? -19.387 10.988 -3.934 1.00 51.73 ? 582 VAL A CG2 1 ATOM 4668 N N . ASP A 1 583 ? -21.438 7.384 -6.297 1.00 53.14 ? 583 ASP A N 1 ATOM 4669 C CA . ASP A 1 583 ? -22.399 6.305 -6.528 1.00 53.31 ? 583 ASP A CA 1 ATOM 4670 C C . ASP A 1 583 ? -23.351 6.188 -5.368 1.00 53.13 ? 583 ASP A C 1 ATOM 4671 O O . ASP A 1 583 ? -22.924 5.968 -4.237 1.00 53.36 ? 583 ASP A O 1 ATOM 4672 C CB . ASP A 1 583 ? -21.671 4.970 -6.658 1.00 53.96 ? 583 ASP A CB 1 ATOM 4673 C CG . ASP A 1 583 ? -20.842 4.860 -7.923 1.00 54.61 ? 583 ASP A CG 1 ATOM 4674 O OD1 . ASP A 1 583 ? -20.543 5.900 -8.562 1.00 56.12 ? 583 ASP A OD1 1 ATOM 4675 O OD2 . ASP A 1 583 ? -20.480 3.709 -8.258 1.00 54.81 ? 583 ASP A OD2 1 ATOM 4676 N N . LYS A 1 584 ? -24.635 6.340 -5.669 1.00 52.92 ? 584 LYS A N 1 ATOM 4677 C CA . LYS A 1 584 ? -25.707 6.242 -4.699 1.00 52.76 ? 584 LYS A CA 1 ATOM 4678 C C . LYS A 1 584 ? -26.208 4.800 -4.705 1.00 52.72 ? 584 LYS A C 1 ATOM 4679 O O . LYS A 1 584 ? -25.682 3.950 -5.447 1.00 52.69 ? 584 LYS A O 1 ATOM 4680 C CB . LYS A 1 584 ? -26.833 7.221 -5.057 1.00 52.92 ? 584 LYS A CB 1 ATOM 4681 C CG . LYS A 1 584 ? -26.359 8.369 -5.982 1.00 54.24 ? 584 LYS A CG 1 ATOM 4682 C CD . LYS A 1 584 ? -27.298 9.567 -6.056 1.00 56.06 ? 584 LYS A CD 1 ATOM 4683 C CE . LYS A 1 584 ? -26.724 10.610 -7.026 1.00 57.39 ? 584 LYS A CE 1 ATOM 4684 N NZ . LYS A 1 584 ? -27.081 12.014 -6.648 1.00 57.38 ? 584 LYS A NZ 1 ATOM 4685 N N . LEU A 1 585 ? -27.205 4.522 -3.867 1.00 52.02 ? 585 LEU A N 1 ATOM 4686 C CA . LEU A 1 585 ? -27.772 3.201 -3.786 1.00 50.96 ? 585 LEU A CA 1 ATOM 4687 C C . LEU A 1 585 ? -28.948 3.123 -4.737 1.00 51.49 ? 585 LEU A C 1 ATOM 4688 O O . LEU A 1 585 ? -30.023 3.687 -4.465 1.00 51.28 ? 585 LEU A O 1 ATOM 4689 C CB . LEU A 1 585 ? -28.209 2.881 -2.349 1.00 50.36 ? 585 LEU A CB 1 ATOM 4690 C CG . LEU A 1 585 ? -28.804 1.486 -2.076 1.00 47.58 ? 585 LEU A CG 1 ATOM 4691 C CD1 . LEU A 1 585 ? -27.807 0.371 -2.344 1.00 42.04 ? 585 LEU A CD1 1 ATOM 4692 C CD2 . LEU A 1 585 ? -29.374 1.410 -0.659 1.00 45.45 ? 585 LEU A CD2 1 ATOM 4693 N N . ASP A 1 586 ? -28.744 2.417 -5.849 1.00 51.93 ? 586 ASP A N 1 ATOM 4694 C CA . ASP A 1 586 ? -29.801 2.245 -6.845 1.00 52.06 ? 586 ASP A CA 1 ATOM 4695 C C . ASP A 1 586 ? -30.835 1.252 -6.357 1.00 51.99 ? 586 ASP A C 1 ATOM 4696 O O . ASP A 1 586 ? -30.620 0.042 -6.396 1.00 52.34 ? 586 ASP A O 1 ATOM 4697 C CB . ASP A 1 586 ? -29.225 1.816 -8.196 1.00 52.45 ? 586 ASP A CB 1 ATOM 4698 C CG . ASP A 1 586 ? -30.293 1.287 -9.150 1.00 52.75 ? 586 ASP A CG 1 ATOM 4699 O OD1 . ASP A 1 586 ? -31.459 1.735 -9.063 1.00 54.14 ? 586 ASP A OD1 1 ATOM 4700 O OD2 . ASP A 1 586 ? -29.969 0.407 -9.976 1.00 52.62 ? 586 ASP A OD2 1 ATOM 4701 N N . LEU A 1 587 ? -31.977 1.771 -5.930 1.00 51.84 ? 587 LEU A N 1 ATOM 4702 C CA . LEU A 1 587 ? -33.004 0.958 -5.287 1.00 51.64 ? 587 LEU A CA 1 ATOM 4703 C C . LEU A 1 587 ? -34.005 0.241 -6.214 1.00 52.15 ? 587 LEU A C 1 ATOM 4704 O O . LEU A 1 587 ? -35.083 -0.203 -5.761 1.00 51.91 ? 587 LEU A O 1 ATOM 4705 C CB . LEU A 1 587 ? -33.738 1.813 -4.264 1.00 51.25 ? 587 LEU A CB 1 ATOM 4706 C CG . LEU A 1 587 ? -32.852 2.105 -3.063 1.00 51.14 ? 587 LEU A CG 1 ATOM 4707 C CD1 . LEU A 1 587 ? -33.315 3.352 -2.312 1.00 52.15 ? 587 LEU A CD1 1 ATOM 4708 C CD2 . LEU A 1 587 ? -32.823 0.890 -2.151 1.00 50.53 ? 587 LEU A CD2 1 ATOM 4709 N N . SER A 1 588 ? -33.660 0.105 -7.496 1.00 52.31 ? 588 SER A N 1 ATOM 4710 C CA . SER A 1 588 ? -34.601 -0.534 -8.438 1.00 52.82 ? 588 SER A CA 1 ATOM 4711 C C . SER A 1 588 ? -34.844 -2.040 -8.180 1.00 52.61 ? 588 SER A C 1 ATOM 4712 O O . SER A 1 588 ? -36.000 -2.460 -8.167 1.00 52.02 ? 588 SER A O 1 ATOM 4713 C CB . SER A 1 588 ? -34.273 -0.232 -9.910 1.00 52.44 ? 588 SER A CB 1 ATOM 4714 O OG . SER A 1 588 ? -32.891 -0.010 -10.098 1.00 53.39 ? 588 SER A OG 1 ATOM 4715 N N . PRO A 1 589 ? -33.772 -2.840 -7.932 1.00 52.90 ? 589 PRO A N 1 ATOM 4716 C CA . PRO A 1 589 ? -33.978 -4.275 -7.695 1.00 53.03 ? 589 PRO A CA 1 ATOM 4717 C C . PRO A 1 589 ? -34.983 -4.605 -6.582 1.00 53.70 ? 589 PRO A C 1 ATOM 4718 O O . PRO A 1 589 ? -35.392 -5.758 -6.438 1.00 53.74 ? 589 PRO A O 1 ATOM 4719 C CB . PRO A 1 589 ? -32.576 -4.764 -7.353 1.00 52.92 ? 589 PRO A CB 1 ATOM 4720 C CG . PRO A 1 589 ? -31.689 -3.893 -8.197 1.00 52.55 ? 589 PRO A CG 1 ATOM 4721 C CD . PRO A 1 589 ? -32.329 -2.531 -8.055 1.00 52.91 ? 589 PRO A CD 1 ATOM 4722 N N . TRP A 1 590 ? -35.407 -3.587 -5.840 1.00 54.46 ? 590 TRP A N 1 ATOM 4723 C CA . TRP A 1 590 ? -36.429 -3.741 -4.812 1.00 55.00 ? 590 TRP A CA 1 ATOM 4724 C C . TRP A 1 590 ? -37.824 -3.415 -5.362 1.00 56.62 ? 590 TRP A C 1 ATOM 4725 O O . TRP A 1 590 ? -38.826 -3.524 -4.639 1.00 56.62 ? 590 TRP A O 1 ATOM 4726 C CB . TRP A 1 590 ? -36.103 -2.862 -3.588 1.00 54.53 ? 590 TRP A CB 1 ATOM 4727 C CG . TRP A 1 590 ? -34.992 -3.387 -2.660 1.00 50.64 ? 590 TRP A CG 1 ATOM 4728 C CD1 . TRP A 1 590 ? -35.161 -4.023 -1.454 1.00 48.43 ? 590 TRP A CD1 1 ATOM 4729 C CD2 . TRP A 1 590 ? -33.575 -3.296 -2.866 1.00 46.19 ? 590 TRP A CD2 1 ATOM 4730 N NE1 . TRP A 1 590 ? -33.943 -4.341 -0.911 1.00 46.13 ? 590 TRP A NE1 1 ATOM 4731 C CE2 . TRP A 1 590 ? -32.951 -3.912 -1.754 1.00 44.81 ? 590 TRP A CE2 1 ATOM 4732 C CE3 . TRP A 1 590 ? -32.772 -2.771 -3.890 1.00 44.09 ? 590 TRP A CE3 1 ATOM 4733 C CZ2 . TRP A 1 590 ? -31.560 -4.011 -1.632 1.00 42.90 ? 590 TRP A CZ2 1 ATOM 4734 C CZ3 . TRP A 1 590 ? -31.377 -2.862 -3.769 1.00 43.65 ? 590 TRP A CZ3 1 ATOM 4735 C CH2 . TRP A 1 590 ? -30.788 -3.480 -2.643 1.00 43.26 ? 590 TRP A CH2 1 ATOM 4736 N N . ALA A 1 591 ? -37.884 -3.002 -6.633 1.00 58.75 ? 591 ALA A N 1 ATOM 4737 C CA . ALA A 1 591 ? -39.164 -2.863 -7.368 1.00 60.89 ? 591 ALA A CA 1 ATOM 4738 C C . ALA A 1 591 ? -39.893 -4.215 -7.481 1.00 62.42 ? 591 ALA A C 1 ATOM 4739 O O . ALA A 1 591 ? -39.329 -5.200 -7.989 1.00 62.33 ? 591 ALA A O 1 ATOM 4740 C CB . ALA A 1 591 ? -38.940 -2.259 -8.758 1.00 60.56 ? 591 ALA A CB 1 ATOM 4741 N N . SER A 1 592 ? -41.133 -4.254 -6.989 1.00 64.28 ? 592 SER A N 1 ATOM 4742 C CA . SER A 1 592 ? -41.934 -5.472 -6.956 1.00 66.26 ? 592 SER A CA 1 ATOM 4743 C C . SER A 1 592 ? -42.110 -6.107 -8.354 1.00 67.94 ? 592 SER A C 1 ATOM 4744 O O . SER A 1 592 ? -42.699 -5.508 -9.258 1.00 68.00 ? 592 SER A O 1 ATOM 4745 C CB . SER A 1 592 ? -43.287 -5.176 -6.296 1.00 66.15 ? 592 SER A CB 1 ATOM 4746 O OG . SER A 1 592 ? -44.038 -6.353 -6.000 1.00 66.39 ? 592 SER A OG 1 ATOM 4747 N N . ARG A 1 593 ? -41.579 -7.318 -8.520 1.00 70.04 ? 593 ARG A N 1 ATOM 4748 C CA . ARG A 1 593 ? -41.789 -8.094 -9.743 1.00 72.22 ? 593 ARG A CA 1 ATOM 4749 C C . ARG A 1 593 ? -43.186 -8.742 -9.710 1.00 73.44 ? 593 ARG A C 1 ATOM 4750 O O . ARG A 1 593 ? -43.501 -9.629 -10.527 1.00 73.72 ? 593 ARG A O 1 ATOM 4751 C CB . ARG A 1 593 ? -40.658 -9.126 -9.940 1.00 72.50 ? 593 ARG A CB 1 ATOM 4752 C CG . ARG A 1 593 ? -40.469 -9.652 -11.375 1.00 73.89 ? 593 ARG A CG 1 ATOM 4753 C CD . ARG A 1 593 ? -40.497 -8.528 -12.438 1.00 76.30 ? 593 ARG A CD 1 ATOM 4754 N NE . ARG A 1 593 ? -40.647 -9.030 -13.814 1.00 77.25 ? 593 ARG A NE 1 ATOM 4755 C CZ . ARG A 1 593 ? -41.805 -9.364 -14.390 1.00 77.12 ? 593 ARG A CZ 1 ATOM 4756 N NH1 . ARG A 1 593 ? -42.953 -9.276 -13.727 1.00 76.35 ? 593 ARG A NH1 1 ATOM 4757 N NH2 . ARG A 1 593 ? -41.812 -9.802 -15.642 1.00 77.15 ? 593 ARG A NH2 1 ATOM 4758 N N . GLU A 1 594 ? -44.000 -8.278 -8.746 1.00 74.59 ? 594 GLU A N 1 ATOM 4759 C CA . GLU A 1 594 ? -45.426 -8.602 -8.609 1.00 75.60 ? 594 GLU A CA 1 ATOM 4760 C C . GLU A 1 594 ? -46.238 -7.354 -8.944 1.00 76.15 ? 594 GLU A C 1 ATOM 4761 O O . GLU A 1 594 ? -45.713 -6.234 -8.900 1.00 76.32 ? 594 GLU A O 1 ATOM 4762 C CB . GLU A 1 594 ? -45.778 -9.011 -7.168 1.00 75.77 ? 594 GLU A CB 1 ATOM 4763 C CG . GLU A 1 594 ? -44.812 -9.965 -6.462 1.00 76.68 ? 594 GLU A CG 1 ATOM 4764 C CD . GLU A 1 594 ? -45.075 -10.049 -4.959 1.00 78.00 ? 594 GLU A CD 1 ATOM 4765 O OE1 . GLU A 1 594 ? -45.344 -8.993 -4.338 1.00 78.07 ? 594 GLU A OE1 1 ATOM 4766 O OE2 . GLU A 1 594 ? -45.013 -11.168 -4.396 1.00 78.35 ? 594 GLU A OE2 1 ATOM 4767 N N . ASN A 1 595 ? -47.522 -7.545 -9.249 1.00 76.58 ? 595 ASN A N 1 ATOM 4768 C CA . ASN A 1 595 ? -48.423 -6.422 -9.533 1.00 76.95 ? 595 ASN A CA 1 ATOM 4769 C C . ASN A 1 595 ? -48.881 -5.714 -8.251 1.00 76.93 ? 595 ASN A C 1 ATOM 4770 O O . ASN A 1 595 ? -48.682 -6.217 -7.139 1.00 76.85 ? 595 ASN A O 1 ATOM 4771 C CB . ASN A 1 595 ? -49.632 -6.887 -10.372 1.00 77.12 ? 595 ASN A CB 1 ATOM 4772 C CG . ASN A 1 595 ? -50.280 -5.749 -11.173 1.00 76.98 ? 595 ASN A CG 1 ATOM 4773 O OD1 . ASN A 1 595 ? -51.385 -5.307 -10.855 1.00 76.64 ? 595 ASN A OD1 1 ATOM 4774 N ND2 . ASN A 1 595 ? -49.593 -5.281 -12.216 1.00 75.78 ? 595 ASN A ND2 1 HETATM 4775 CA CA . CA B 2 . ? -27.012 -6.870 16.780 1.00 26.80 ? 601 CA A CA 1 HETATM 4776 C CHA . HEM C 3 . ? -18.286 -0.029 27.433 1.00 19.50 ? 602 HEM A CHA 1 HETATM 4777 C CHB . HEM C 3 . ? -18.059 4.745 27.300 1.00 18.13 ? 602 HEM A CHB 1 HETATM 4778 C CHC . HEM C 3 . ? -16.098 4.573 22.867 1.00 16.15 ? 602 HEM A CHC 1 HETATM 4779 C CHD . HEM C 3 . ? -16.474 -0.168 22.918 1.00 17.61 ? 602 HEM A CHD 1 HETATM 4780 C C1A . HEM C 3 . ? -18.410 1.272 27.772 1.00 19.20 ? 602 HEM A C1A 1 HETATM 4781 C C2A . HEM C 3 . ? -19.017 1.733 28.996 1.00 20.67 ? 602 HEM A C2A 1 HETATM 4782 C C3A . HEM C 3 . ? -18.978 3.070 28.976 1.00 20.89 ? 602 HEM A C3A 1 HETATM 4783 C C4A . HEM C 3 . ? -18.319 3.473 27.723 1.00 18.69 ? 602 HEM A C4A 1 HETATM 4784 C CMA . HEM C 3 . ? -19.510 3.996 30.099 1.00 16.76 ? 602 HEM A CMA 1 HETATM 4785 C CAA . HEM C 3 . ? -19.621 0.809 30.081 1.00 19.21 ? 602 HEM A CAA 1 HETATM 4786 C CBA . HEM C 3 . ? -18.463 0.461 30.989 1.00 24.22 ? 602 HEM A CBA 1 HETATM 4787 C CGA . HEM C 3 . ? -18.858 -0.522 32.054 1.00 23.44 ? 602 HEM A CGA 1 HETATM 4788 O O1A . HEM C 3 . ? -18.360 -1.666 31.972 1.00 22.94 ? 602 HEM A O1A 1 HETATM 4789 O O2A . HEM C 3 . ? -19.648 -0.145 32.958 1.00 24.71 ? 602 HEM A O2A 1 HETATM 4790 C C1B . HEM C 3 . ? -17.534 5.116 26.069 1.00 17.65 ? 602 HEM A C1B 1 HETATM 4791 C C2B . HEM C 3 . ? -17.460 6.457 25.541 1.00 12.73 ? 602 HEM A C2B 1 HETATM 4792 C C3B . HEM C 3 . ? -16.934 6.428 24.335 1.00 14.30 ? 602 HEM A C3B 1 HETATM 4793 C C4B . HEM C 3 . ? -16.669 5.040 24.032 1.00 17.80 ? 602 HEM A C4B 1 HETATM 4794 C CMB . HEM C 3 . ? -17.895 7.719 26.291 1.00 11.46 ? 602 HEM A CMB 1 HETATM 4795 C CAB . HEM C 3 . ? -16.620 7.662 23.433 1.00 14.76 ? 602 HEM A CAB 1 HETATM 4796 C CBB . HEM C 3 . ? -16.358 8.871 24.001 1.00 12.21 ? 602 HEM A CBB 1 HETATM 4797 C C1C . HEM C 3 . ? -15.990 3.287 22.492 1.00 16.54 ? 602 HEM A C1C 1 HETATM 4798 C C2C . HEM C 3 . ? -15.387 2.799 21.266 1.00 19.32 ? 602 HEM A C2C 1 HETATM 4799 C C3C . HEM C 3 . ? -15.517 1.452 21.262 1.00 18.16 ? 602 HEM A C3C 1 HETATM 4800 C C4C . HEM C 3 . ? -16.177 1.088 22.502 1.00 16.47 ? 602 HEM A C4C 1 HETATM 4801 C CMC . HEM C 3 . ? -14.743 3.715 20.208 1.00 18.05 ? 602 HEM A CMC 1 HETATM 4802 C CAC . HEM C 3 . ? -15.082 0.404 20.218 1.00 18.10 ? 602 HEM A CAC 1 HETATM 4803 C CBC . HEM C 3 . ? -14.383 0.612 19.104 1.00 19.37 ? 602 HEM A CBC 1 HETATM 4804 C C1D . HEM C 3 . ? -17.058 -0.555 24.103 1.00 18.33 ? 602 HEM A C1D 1 HETATM 4805 C C2D . HEM C 3 . ? -17.537 -1.884 24.361 1.00 18.33 ? 602 HEM A C2D 1 HETATM 4806 C C3D . HEM C 3 . ? -18.107 -1.861 25.758 1.00 18.30 ? 602 HEM A C3D 1 HETATM 4807 C C4D . HEM C 3 . ? -17.912 -0.503 26.206 1.00 19.15 ? 602 HEM A C4D 1 HETATM 4808 C CMD . HEM C 3 . ? -17.480 -3.125 23.459 1.00 17.59 ? 602 HEM A CMD 1 HETATM 4809 C CAD . HEM C 3 . ? -18.775 -3.058 26.468 1.00 19.14 ? 602 HEM A CAD 1 HETATM 4810 C CBD . HEM C 3 . ? -20.248 -3.103 26.021 1.00 17.32 ? 602 HEM A CBD 1 HETATM 4811 C CGD . HEM C 3 . ? -20.971 -4.208 26.722 1.00 19.07 ? 602 HEM A CGD 1 HETATM 4812 O O1D . HEM C 3 . ? -21.598 -4.021 27.813 1.00 20.61 ? 602 HEM A O1D 1 HETATM 4813 O O2D . HEM C 3 . ? -20.900 -5.318 26.170 1.00 20.28 ? 602 HEM A O2D 1 HETATM 4814 N NA . HEM C 3 . ? -17.967 2.344 27.032 1.00 19.13 ? 602 HEM A NA 1 HETATM 4815 N NB . HEM C 3 . ? -17.052 4.268 25.105 1.00 19.13 ? 602 HEM A NB 1 HETATM 4816 N NC . HEM C 3 . ? -16.437 2.219 23.235 1.00 19.12 ? 602 HEM A NC 1 HETATM 4817 N ND . HEM C 3 . ? -17.285 0.230 25.221 1.00 17.63 ? 602 HEM A ND 1 HETATM 4818 FE FE . HEM C 3 . ? -17.213 2.256 25.156 1.00 22.83 ? 602 HEM A FE 1 HETATM 4819 C C1 . NAG D 4 . ? -4.154 4.815 4.964 1.00 51.56 ? 603 NAG A C1 1 HETATM 4820 C C2 . NAG D 4 . ? -2.939 4.604 4.040 1.00 55.17 ? 603 NAG A C2 1 HETATM 4821 C C3 . NAG D 4 . ? -3.282 3.905 2.724 1.00 56.36 ? 603 NAG A C3 1 HETATM 4822 C C4 . NAG D 4 . ? -4.053 2.618 2.995 1.00 57.74 ? 603 NAG A C4 1 HETATM 4823 C C5 . NAG D 4 . ? -5.322 2.950 3.809 1.00 57.60 ? 603 NAG A C5 1 HETATM 4824 C C6 . NAG D 4 . ? -6.027 1.674 4.260 1.00 58.47 ? 603 NAG A C6 1 HETATM 4825 C C7 . NAG D 4 . ? -1.021 6.117 3.777 1.00 57.68 ? 603 NAG A C7 1 HETATM 4826 C C8 . NAG D 4 . ? -0.625 7.515 3.389 1.00 57.63 ? 603 NAG A C8 1 HETATM 4827 N N2 . NAG D 4 . ? -2.327 5.881 3.721 1.00 56.13 ? 603 NAG A N2 1 HETATM 4828 O O3 . NAG D 4 . ? -2.093 3.597 2.034 1.00 57.41 ? 603 NAG A O3 1 HETATM 4829 O O4 . NAG D 4 . ? -4.344 1.943 1.774 1.00 58.17 ? 603 NAG A O4 1 HETATM 4830 O O5 . NAG D 4 . ? -5.056 3.712 4.987 1.00 54.59 ? 603 NAG A O5 1 HETATM 4831 O O6 . NAG D 4 . ? -6.886 1.194 3.243 1.00 60.73 ? 603 NAG A O6 1 HETATM 4832 O O7 . NAG D 4 . ? -0.181 5.270 4.125 1.00 59.22 ? 603 NAG A O7 1 HETATM 4833 C C1 . NAG E 4 . ? -45.027 9.621 11.174 1.00 57.31 ? 604 NAG A C1 1 HETATM 4834 C C2 . NAG E 4 . ? -45.125 10.779 12.182 1.00 57.36 ? 604 NAG A C2 1 HETATM 4835 C C3 . NAG E 4 . ? -46.303 11.702 11.870 1.00 59.48 ? 604 NAG A C3 1 HETATM 4836 C C4 . NAG E 4 . ? -46.336 12.043 10.378 1.00 60.93 ? 604 NAG A C4 1 HETATM 4837 C C5 . NAG E 4 . ? -46.305 10.758 9.541 1.00 60.98 ? 604 NAG A C5 1 HETATM 4838 C C6 . NAG E 4 . ? -46.356 11.046 8.044 1.00 61.77 ? 604 NAG A C6 1 HETATM 4839 C C7 . NAG E 4 . ? -44.287 10.227 14.449 1.00 53.58 ? 604 NAG A C7 1 HETATM 4840 C C8 . NAG E 4 . ? -44.699 9.773 15.815 1.00 54.15 ? 604 NAG A C8 1 HETATM 4841 N N2 . NAG E 4 . ? -45.282 10.331 13.553 1.00 54.23 ? 604 NAG A N2 1 HETATM 4842 O O3 . NAG E 4 . ? -46.155 12.877 12.634 1.00 60.88 ? 604 NAG A O3 1 HETATM 4843 O O4 . NAG E 4 . ? -47.447 12.853 10.063 1.00 62.16 ? 604 NAG A O4 1 HETATM 4844 O O5 . NAG E 4 . ? -45.088 10.070 9.832 1.00 59.81 ? 604 NAG A O5 1 HETATM 4845 O O6 . NAG E 4 . ? -45.100 11.533 7.609 1.00 61.53 ? 604 NAG A O6 1 HETATM 4846 O O7 . NAG E 4 . ? -43.093 10.450 14.236 1.00 51.21 ? 604 NAG A O7 1 HETATM 4847 C C1 . NAG F 4 . ? -27.281 25.669 28.680 1.00 47.86 ? 605 NAG A C1 1 HETATM 4848 C C2 . NAG F 4 . ? -25.880 26.287 28.600 1.00 49.67 ? 605 NAG A C2 1 HETATM 4849 C C3 . NAG F 4 . ? -25.907 27.705 28.016 1.00 49.91 ? 605 NAG A C3 1 HETATM 4850 C C4 . NAG F 4 . ? -26.614 27.675 26.668 1.00 49.82 ? 605 NAG A C4 1 HETATM 4851 C C5 . NAG F 4 . ? -28.018 27.109 26.830 1.00 49.04 ? 605 NAG A C5 1 HETATM 4852 C C6 . NAG F 4 . ? -28.603 26.896 25.440 1.00 50.02 ? 605 NAG A C6 1 HETATM 4853 C C7 . NAG F 4 . ? -24.291 25.371 30.213 1.00 53.50 ? 605 NAG A C7 1 HETATM 4854 C C8 . NAG F 4 . ? -23.718 25.470 31.600 1.00 52.52 ? 605 NAG A C8 1 HETATM 4855 N N2 . NAG F 4 . ? -25.238 26.259 29.903 1.00 51.14 ? 605 NAG A N2 1 HETATM 4856 O O3 . NAG F 4 . ? -24.590 28.210 27.849 1.00 49.18 ? 605 NAG A O3 1 HETATM 4857 O O4 . NAG F 4 . ? -26.648 28.958 26.066 1.00 50.65 ? 605 NAG A O4 1 HETATM 4858 O O5 . NAG F 4 . ? -27.974 25.838 27.451 1.00 49.13 ? 605 NAG A O5 1 HETATM 4859 O O6 . NAG F 4 . ? -29.913 26.383 25.522 1.00 51.00 ? 605 NAG A O6 1 HETATM 4860 O O7 . NAG F 4 . ? -23.887 24.506 29.425 1.00 54.59 ? 605 NAG A O7 1 HETATM 4861 C C1 . NAG G 4 . ? -18.273 -24.843 9.456 1.00 47.94 ? 606 NAG A C1 1 HETATM 4862 C C2 . NAG G 4 . ? -17.773 -26.038 8.642 1.00 52.73 ? 606 NAG A C2 1 HETATM 4863 C C3 . NAG G 4 . ? -16.801 -26.940 9.426 1.00 52.95 ? 606 NAG A C3 1 HETATM 4864 C C4 . NAG G 4 . ? -17.008 -27.043 10.945 1.00 52.96 ? 606 NAG A C4 1 HETATM 4865 C C5 . NAG G 4 . ? -17.995 -26.054 11.610 1.00 50.43 ? 606 NAG A C5 1 HETATM 4866 C C6 . NAG G 4 . ? -17.307 -25.204 12.703 1.00 49.47 ? 606 NAG A C6 1 HETATM 4867 C C7 . NAG G 4 . ? -19.220 -27.202 6.980 1.00 58.04 ? 606 NAG A C7 1 HETATM 4868 C C8 . NAG G 4 . ? -20.468 -28.030 6.831 1.00 58.17 ? 606 NAG A C8 1 HETATM 4869 N N2 . NAG G 4 . ? -18.921 -26.838 8.235 1.00 55.95 ? 606 NAG A N2 1 HETATM 4870 O O3 . NAG G 4 . ? -15.460 -26.542 9.248 1.00 53.79 ? 606 NAG A O3 1 HETATM 4871 O O4 . NAG G 4 . ? -17.344 -28.378 11.282 1.00 56.03 ? 606 NAG A O4 1 HETATM 4872 O O5 . NAG G 4 . ? -18.805 -25.297 10.706 1.00 48.94 ? 606 NAG A O5 1 HETATM 4873 O O6 . NAG G 4 . ? -16.314 -24.322 12.214 1.00 46.54 ? 606 NAG A O6 1 HETATM 4874 O O7 . NAG G 4 . ? -18.550 -26.904 5.981 1.00 59.12 ? 606 NAG A O7 1 HETATM 4875 C C1 . BMM H 5 . ? -20.891 3.147 25.223 1.00 31.19 ? 607 BMM A C1 1 HETATM 4876 BR BR . BMM H 5 . ? -21.900 3.407 26.927 1.00 26.96 ? 607 BMM A BR 1 HETATM 4877 I I . IOD I 6 . ? -14.963 -15.800 27.185 1.00 32.59 ? 608 IOD A I 1 HETATM 4878 I I . IOD J 6 . ? -20.560 21.121 3.188 1.00 53.80 ? 609 IOD A I 1 HETATM 4879 I I . IOD K 6 . ? -18.496 -7.555 2.919 1.00 50.55 ? 610 IOD A I 1 HETATM 4880 I I . IOD L 6 . ? -40.354 13.639 20.724 1.00 57.79 ? 611 IOD A I 1 HETATM 4881 I I . IOD M 6 . ? -1.859 2.312 8.042 1.00 62.04 ? 612 IOD A I 1 HETATM 4882 I I . IOD N 6 . ? -44.090 -15.899 29.459 1.00 59.10 ? 613 IOD A I 1 HETATM 4883 I I . IOD O 6 . ? -1.391 5.676 42.038 1.00 69.98 ? 614 IOD A I 1 HETATM 4884 I I . IOD P 6 . ? -29.019 11.715 36.281 1.00 101.75 ? 615 IOD A I 1 HETATM 4885 I I . IOD Q 6 . ? -11.422 23.241 15.349 1.00 91.56 ? 616 IOD A I 1 HETATM 4886 I I . IOD R 6 . ? -18.532 19.741 32.352 1.00 96.96 ? 617 IOD A I 1 HETATM 4887 I I . IOD S 6 . ? -11.247 21.779 29.490 1.00 95.29 ? 618 IOD A I 1 HETATM 4888 I I . IOD T 6 . ? -6.027 12.986 38.730 1.00 97.12 ? 619 IOD A I 1 HETATM 4889 I I . IOD U 6 . ? -40.046 -10.197 16.564 1.00 98.49 ? 620 IOD A I 1 HETATM 4890 O O . HOH V 7 . ? -3.345 -7.184 20.917 1.00 17.05 ? 701 HOH A O 1 HETATM 4891 O O . HOH V 7 . ? -30.177 19.714 28.886 1.00 24.92 ? 702 HOH A O 1 HETATM 4892 O O . HOH V 7 . ? -21.192 -20.821 26.649 1.00 27.02 ? 703 HOH A O 1 HETATM 4893 O O . HOH V 7 . ? -26.007 -16.933 35.553 1.00 30.57 ? 704 HOH A O 1 HETATM 4894 O O . HOH V 7 . ? -33.620 11.641 28.890 1.00 31.13 ? 705 HOH A O 1 HETATM 4895 O O . HOH V 7 . ? -4.711 3.112 17.261 1.00 21.07 ? 706 HOH A O 1 HETATM 4896 O O . HOH V 7 . ? -16.098 -12.251 1.712 1.00 42.55 ? 707 HOH A O 1 HETATM 4897 O O . HOH V 7 . ? -23.563 -16.295 6.832 1.00 14.92 ? 708 HOH A O 1 HETATM 4898 O O . HOH V 7 . ? -5.303 9.934 31.060 1.00 16.00 ? 709 HOH A O 1 HETATM 4899 O O . HOH V 7 . ? -2.900 -15.677 32.239 1.00 22.78 ? 710 HOH A O 1 HETATM 4900 O O . HOH V 7 . ? -17.482 -20.845 32.637 1.00 41.11 ? 711 HOH A O 1 HETATM 4901 O O . HOH V 7 . ? -30.897 -18.350 16.369 1.00 24.84 ? 712 HOH A O 1 HETATM 4902 O O . HOH V 7 . ? 2.524 -7.049 18.866 1.00 28.67 ? 713 HOH A O 1 HETATM 4903 O O . HOH V 7 . ? -30.830 -3.009 20.798 1.00 17.67 ? 714 HOH A O 1 HETATM 4904 O O . HOH V 7 . ? -34.680 13.242 7.410 1.00 32.18 ? 715 HOH A O 1 HETATM 4905 O O . HOH V 7 . ? -20.643 -5.488 31.851 1.00 20.43 ? 716 HOH A O 1 HETATM 4906 O O . HOH V 7 . ? -5.061 7.959 5.782 1.00 37.45 ? 717 HOH A O 1 HETATM 4907 O O . HOH V 7 . ? -27.641 -19.067 12.469 1.00 24.66 ? 718 HOH A O 1 HETATM 4908 O O . HOH V 7 . ? 0.838 9.677 17.263 1.00 44.04 ? 719 HOH A O 1 HETATM 4909 O O . HOH V 7 . ? -27.534 -15.785 22.211 1.00 23.83 ? 720 HOH A O 1 HETATM 4910 O O . HOH V 7 . ? -21.452 -10.058 37.230 1.00 25.23 ? 721 HOH A O 1 HETATM 4911 O O . HOH V 7 . ? -19.251 -17.640 20.345 1.00 20.47 ? 722 HOH A O 1 HETATM 4912 O O . HOH V 7 . ? -26.469 13.682 -4.630 1.00 44.15 ? 723 HOH A O 1 HETATM 4913 O O . HOH V 7 . ? -8.315 8.082 24.529 1.00 13.49 ? 724 HOH A O 1 HETATM 4914 O O . HOH V 7 . ? -47.701 10.038 15.278 1.00 34.61 ? 725 HOH A O 1 HETATM 4915 O O . HOH V 7 . ? -40.537 -24.354 8.095 1.00 31.50 ? 726 HOH A O 1 HETATM 4916 O O . HOH V 7 . ? 2.287 11.969 21.323 1.00 25.68 ? 727 HOH A O 1 HETATM 4917 O O . HOH V 7 . ? -12.754 -12.365 38.526 1.00 29.29 ? 728 HOH A O 1 HETATM 4918 O O . HOH V 7 . ? -4.849 12.872 28.633 1.00 23.51 ? 729 HOH A O 1 HETATM 4919 O O . HOH V 7 . ? 2.224 3.691 29.923 1.00 15.51 ? 730 HOH A O 1 HETATM 4920 O O . HOH V 7 . ? -24.887 -30.977 36.079 1.00 35.60 ? 731 HOH A O 1 HETATM 4921 O O . HOH V 7 . ? -13.969 16.870 15.730 1.00 23.06 ? 732 HOH A O 1 HETATM 4922 O O . HOH V 7 . ? 4.004 -15.496 19.938 1.00 24.50 ? 733 HOH A O 1 HETATM 4923 O O . HOH V 7 . ? -37.288 15.720 13.882 1.00 33.30 ? 734 HOH A O 1 HETATM 4924 O O . HOH V 7 . ? -44.645 -7.332 -2.729 1.00 55.26 ? 735 HOH A O 1 HETATM 4925 O O . HOH V 7 . ? -6.232 0.987 18.577 1.00 18.83 ? 736 HOH A O 1 HETATM 4926 O O . HOH V 7 . ? -33.027 4.310 16.495 1.00 26.33 ? 737 HOH A O 1 HETATM 4927 O O . HOH V 7 . ? -22.777 20.521 18.681 1.00 23.79 ? 738 HOH A O 1 HETATM 4928 O O . HOH V 7 . ? -18.406 2.269 -2.349 1.00 39.14 ? 739 HOH A O 1 HETATM 4929 O O . HOH V 7 . ? -6.620 5.062 15.958 1.00 24.85 ? 740 HOH A O 1 HETATM 4930 O O . HOH V 7 . ? 3.390 -11.629 20.026 1.00 24.64 ? 741 HOH A O 1 HETATM 4931 O O . HOH V 7 . ? -17.233 13.427 48.750 1.00 36.17 ? 742 HOH A O 1 HETATM 4932 O O . HOH V 7 . ? -20.627 -15.274 30.188 1.00 21.59 ? 743 HOH A O 1 HETATM 4933 O O . HOH V 7 . ? -39.110 -23.124 19.316 1.00 41.68 ? 744 HOH A O 1 HETATM 4934 O O . HOH V 7 . ? -35.673 15.424 35.072 1.00 44.24 ? 745 HOH A O 1 HETATM 4935 O O . HOH V 7 . ? -19.584 2.078 36.982 1.00 42.16 ? 746 HOH A O 1 HETATM 4936 O O . HOH V 7 . ? -27.866 -19.939 29.972 1.00 34.77 ? 747 HOH A O 1 HETATM 4937 O O . HOH V 7 . ? -9.905 14.863 16.983 1.00 20.04 ? 748 HOH A O 1 HETATM 4938 O O . HOH V 7 . ? -16.975 -10.549 3.710 1.00 27.30 ? 749 HOH A O 1 HETATM 4939 O O . HOH V 7 . ? -9.106 0.868 41.846 1.00 28.37 ? 750 HOH A O 1 HETATM 4940 O O . HOH V 7 . ? -11.836 -1.475 44.400 1.00 30.52 ? 751 HOH A O 1 HETATM 4941 O O . HOH V 7 . ? -27.913 3.685 50.744 1.00 42.52 ? 752 HOH A O 1 HETATM 4942 O O . HOH V 7 . ? -20.493 21.484 26.203 1.00 27.89 ? 753 HOH A O 1 HETATM 4943 O O . HOH V 7 . ? -12.434 -11.241 4.067 1.00 37.69 ? 754 HOH A O 1 HETATM 4944 O O . HOH V 7 . ? -21.309 -10.416 48.947 1.00 43.67 ? 755 HOH A O 1 HETATM 4945 O O . HOH V 7 . ? -21.899 -19.048 28.237 1.00 21.71 ? 756 HOH A O 1 HETATM 4946 O O . HOH V 7 . ? -42.489 2.095 9.820 1.00 28.55 ? 757 HOH A O 1 HETATM 4947 O O . HOH V 7 . ? -20.729 -16.932 45.064 1.00 39.70 ? 758 HOH A O 1 HETATM 4948 O O . HOH V 7 . ? -33.778 11.121 5.365 1.00 24.66 ? 759 HOH A O 1 HETATM 4949 O O . HOH V 7 . ? -43.245 -7.694 13.477 1.00 27.42 ? 760 HOH A O 1 HETATM 4950 O O . HOH V 7 . ? -25.837 -24.293 6.458 1.00 30.24 ? 761 HOH A O 1 HETATM 4951 O O . HOH V 7 . ? -31.811 -22.985 21.166 1.00 31.39 ? 762 HOH A O 1 HETATM 4952 O O . HOH V 7 . ? -21.406 16.605 29.425 1.00 34.82 ? 763 HOH A O 1 HETATM 4953 O O . HOH V 7 . ? -18.085 -21.887 15.794 1.00 32.79 ? 764 HOH A O 1 HETATM 4954 O O . HOH V 7 . ? -5.081 -9.039 5.200 1.00 50.03 ? 765 HOH A O 1 HETATM 4955 O O . HOH V 7 . ? -32.840 4.287 -6.206 1.00 42.41 ? 766 HOH A O 1 HETATM 4956 O O . HOH V 7 . ? -4.683 10.041 38.024 1.00 22.45 ? 767 HOH A O 1 HETATM 4957 O O . HOH V 7 . ? -30.543 -26.577 20.785 1.00 42.46 ? 768 HOH A O 1 HETATM 4958 O O . HOH V 7 . ? -22.225 7.692 -9.645 1.00 43.94 ? 769 HOH A O 1 HETATM 4959 O O . HOH V 7 . ? 0.962 -20.718 23.754 1.00 18.61 ? 770 HOH A O 1 HETATM 4960 O O . HOH V 7 . ? -27.754 -18.257 23.491 1.00 29.13 ? 771 HOH A O 1 HETATM 4961 O O . HOH V 7 . ? -0.496 5.891 29.164 1.00 19.24 ? 772 HOH A O 1 HETATM 4962 O O . HOH V 7 . ? -0.150 6.685 33.403 1.00 32.16 ? 773 HOH A O 1 HETATM 4963 O O . HOH V 7 . ? -33.038 -6.358 16.434 1.00 31.44 ? 774 HOH A O 1 HETATM 4964 O O . HOH V 7 . ? 7.656 3.986 23.829 1.00 36.64 ? 775 HOH A O 1 HETATM 4965 O O . HOH V 7 . ? -33.845 -14.215 13.317 1.00 23.45 ? 776 HOH A O 1 HETATM 4966 O O . HOH V 7 . ? -25.516 -8.897 52.012 1.00 54.06 ? 777 HOH A O 1 HETATM 4967 O O . HOH V 7 . ? -21.154 -10.041 44.373 1.00 41.81 ? 778 HOH A O 1 HETATM 4968 O O . HOH V 7 . ? -31.519 12.779 17.501 1.00 32.55 ? 779 HOH A O 1 HETATM 4969 O O . HOH V 7 . ? -40.643 22.431 21.090 1.00 42.52 ? 780 HOH A O 1 HETATM 4970 O O . HOH V 7 . ? -11.804 23.325 23.489 1.00 32.28 ? 781 HOH A O 1 HETATM 4971 O O . HOH V 7 . ? -3.482 11.283 33.495 1.00 30.28 ? 782 HOH A O 1 HETATM 4972 O O . HOH V 7 . ? -35.827 -16.393 4.604 1.00 37.58 ? 783 HOH A O 1 HETATM 4973 O O . HOH V 7 . ? -17.198 7.234 -0.565 1.00 36.27 ? 784 HOH A O 1 HETATM 4974 O O . HOH V 7 . ? -36.558 21.302 10.406 1.00 45.88 ? 785 HOH A O 1 HETATM 4975 O O . HOH V 7 . ? -39.070 16.391 10.002 1.00 41.29 ? 786 HOH A O 1 HETATM 4976 O O . HOH V 7 . ? -2.573 15.221 44.625 1.00 45.03 ? 787 HOH A O 1 HETATM 4977 O O . HOH V 7 . ? -24.262 -31.281 12.344 1.00 47.65 ? 788 HOH A O 1 HETATM 4978 O O . HOH V 7 . ? -26.843 0.941 38.447 1.00 44.70 ? 789 HOH A O 1 HETATM 4979 O O . HOH V 7 . ? -42.160 22.232 19.166 1.00 40.70 ? 790 HOH A O 1 HETATM 4980 O O . HOH V 7 . ? 1.591 -3.309 2.718 1.00 35.28 ? 791 HOH A O 1 HETATM 4981 O O . HOH V 7 . ? -10.254 -17.632 56.279 1.00 41.80 ? 792 HOH A O 1 HETATM 4982 O O . HOH V 7 . ? -28.344 17.536 26.523 1.00 46.15 ? 793 HOH A O 1 HETATM 4983 O O . HOH V 7 . ? -20.342 5.488 -2.881 1.00 39.65 ? 794 HOH A O 1 HETATM 4984 O O . HOH V 7 . ? -9.774 13.025 9.013 1.00 36.79 ? 795 HOH A O 1 HETATM 4985 O O . HOH V 7 . ? -45.862 -8.977 1.396 1.00 25.52 ? 796 HOH A O 1 HETATM 4986 O O . HOH V 7 . ? -36.946 1.581 47.993 1.00 44.90 ? 797 HOH A O 1 HETATM 4987 O O . HOH V 7 . ? -13.424 -20.206 9.319 1.00 42.26 ? 798 HOH A O 1 HETATM 4988 O O . HOH V 7 . ? -28.724 -18.410 28.355 1.00 14.61 ? 799 HOH A O 1 HETATM 4989 O O . HOH V 7 . ? -25.652 2.976 21.192 1.00 15.10 ? 800 HOH A O 1 HETATM 4990 O O . HOH V 7 . ? -29.337 -24.884 12.302 1.00 40.50 ? 801 HOH A O 1 HETATM 4991 O O . HOH V 7 . ? -6.881 2.320 -0.513 1.00 39.06 ? 802 HOH A O 1 HETATM 4992 O O . HOH V 7 . ? -12.459 0.592 1.725 1.00 29.33 ? 803 HOH A O 1 HETATM 4993 O O . HOH V 7 . ? -35.930 5.174 -6.619 1.00 50.33 ? 804 HOH A O 1 HETATM 4994 O O . HOH V 7 . ? -37.242 -7.959 -6.242 1.00 40.27 ? 805 HOH A O 1 HETATM 4995 O O . HOH V 7 . ? 5.527 -19.410 26.862 1.00 41.35 ? 806 HOH A O 1 HETATM 4996 O O . HOH V 7 . ? -2.604 -1.910 44.025 1.00 36.65 ? 807 HOH A O 1 HETATM 4997 O O . HOH V 7 . ? -31.422 -12.478 13.203 1.00 32.11 ? 808 HOH A O 1 HETATM 4998 O O . HOH V 7 . ? -14.403 -2.843 46.637 1.00 25.50 ? 809 HOH A O 1 HETATM 4999 O O . HOH V 7 . ? -41.217 8.779 28.807 1.00 55.60 ? 810 HOH A O 1 HETATM 5000 O O . HOH V 7 . ? -26.824 29.984 23.900 1.00 45.59 ? 811 HOH A O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 SER 1 1 1 SER SER A . n A 1 2 TRP 2 2 2 TRP TRP A . n A 1 3 GLU 3 3 3 GLU GLU A . n A 1 4 VAL 4 4 4 VAL VAL A . n A 1 5 GLY 5 5 5 GLY GLY A . n A 1 6 CYS 6 6 6 CYS CYS A . n A 1 7 GLY 7 7 7 GLY GLY A . n A 1 8 ALA 8 8 8 ALA ALA A . n A 1 9 PRO 9 9 9 PRO PRO A . n A 1 10 VAL 10 10 10 VAL VAL A . n A 1 11 PRO 11 11 11 PRO PRO A . n A 1 12 LEU 12 12 12 LEU LEU A . n A 1 13 VAL 13 13 13 VAL VAL A . n A 1 14 LYS 14 14 14 LYS LYS A . n A 1 15 CYS 15 15 15 CYS CYS A . n A 1 16 ASP 16 16 16 ASP ASP A . n A 1 17 GLU 17 17 17 GLU GLU A . n A 1 18 ASN 18 18 18 ASN ASN A . n A 1 19 SER 19 19 19 SER SER A . n A 1 20 PRO 20 20 20 PRO PRO A . n A 1 21 TYR 21 21 21 TYR TYR A . n A 1 22 ARG 22 22 22 ARG ARG A . n A 1 23 THR 23 23 23 THR THR A . n A 1 24 ILE 24 24 24 ILE ILE A . n A 1 25 THR 25 25 25 THR THR A . n A 1 26 GLY 26 26 26 GLY GLY A . n A 1 27 ASP 27 27 27 ASP ASP A . n A 1 28 CYS 28 28 28 CYS CYS A . n A 1 29 ASN 29 29 29 ASN ASN A . n A 1 30 ASN 30 30 30 ASN ASN A . n A 1 31 ARG 31 31 31 ARG ARG A . n A 1 32 ARG 32 32 32 ARG ARG A . n A 1 33 SER 33 33 33 SER SER A . n A 1 34 PRO 34 34 34 PRO PRO A . n A 1 35 ALA 35 35 35 ALA ALA A . n A 1 36 LEU 36 36 36 LEU LEU A . n A 1 37 GLY 37 37 37 GLY GLY A . n A 1 38 ALA 38 38 38 ALA ALA A . n A 1 39 ALA 39 39 39 ALA ALA A . n A 1 40 ASN 40 40 40 ASN ASN A . n A 1 41 ARG 41 41 41 ARG ARG A . n A 1 42 ALA 42 42 42 ALA ALA A . n A 1 43 LEU 43 43 43 LEU LEU A . n A 1 44 ALA 44 44 44 ALA ALA A . n A 1 45 ARG 45 45 45 ARG ARG A . n A 1 46 TRP 46 46 46 TRP TRP A . n A 1 47 LEU 47 47 47 LEU LEU A . n A 1 48 PRO 48 48 48 PRO PRO A . n A 1 49 ALA 49 49 49 ALA ALA A . n A 1 50 GLU 50 50 50 GLU GLU A . n A 1 51 TYR 51 51 51 TYR TYR A . n A 1 52 GLU 52 52 52 GLU GLU A . n A 1 53 ASP 53 53 53 ASP ASP A . n A 1 54 GLY 54 54 54 GLY GLY A . n A 1 55 LEU 55 55 55 LEU LEU A . n A 1 56 ALA 56 56 56 ALA ALA A . n A 1 57 LEU 57 57 57 LEU LEU A . n A 1 58 PRO 58 58 58 PRO PRO A . n A 1 59 PHE 59 59 59 PHE PHE A . n A 1 60 GLY 60 60 60 GLY GLY A . n A 1 61 TRP 61 61 61 TRP TRP A . n A 1 62 THR 62 62 62 THR THR A . n A 1 63 GLN 63 63 63 GLN GLN A . n A 1 64 ARG 64 64 64 ARG ARG A . n A 1 65 LYS 65 65 65 LYS LYS A . n A 1 66 THR 66 66 66 THR THR A . n A 1 67 ARG 67 67 67 ARG ARG A . n A 1 68 ASN 68 68 68 ASN ASN A . n A 1 69 GLY 69 69 69 GLY GLY A . n A 1 70 PHE 70 70 70 PHE PHE A . n A 1 71 ARG 71 71 71 ARG ARG A . n A 1 72 VAL 72 72 72 VAL VAL A . n A 1 73 PRO 73 73 73 PRO PRO A . n A 1 74 LEU 74 74 74 LEU LEU A . n A 1 75 ALA 75 75 75 ALA ALA A . n A 1 76 ARG 76 76 76 ARG ARG A . n A 1 77 GLU 77 77 77 GLU GLU A . n A 1 78 VAL 78 78 78 VAL VAL A . n A 1 79 SER 79 79 79 SER SER A . n A 1 80 ASN 80 80 80 ASN ASN A . n A 1 81 LYS 81 81 81 LYS LYS A . n A 1 82 ILE 82 82 82 ILE ILE A . n A 1 83 VAL 83 83 83 VAL VAL A . n A 1 84 GLY 84 84 84 GLY GLY A . n A 1 85 TYR 85 85 85 TYR TYR A . n A 1 86 LEU 86 86 86 LEU LEU A . n A 1 87 ASP 87 87 87 ASP ASP A . n A 1 88 GLU 88 88 88 GLU GLU A . n A 1 89 GLU 89 89 89 GLU GLU A . n A 1 90 GLY 90 90 90 GLY GLY A . n A 1 91 VAL 91 91 91 VAL VAL A . n A 1 92 LEU 92 92 92 LEU LEU A . n A 1 93 ASP 93 93 93 ASP ASP A . n A 1 94 GLN 94 94 94 GLN GLN A . n A 1 95 ASN 95 95 95 ASN ASN A . n A 1 96 ARG 96 96 96 ARG ARG A . n A 1 97 SER 97 97 97 SER SER A . n A 1 98 LEU 98 98 98 LEU LEU A . n A 1 99 LEU 99 99 99 LEU LEU A . n A 1 100 PHE 100 100 100 PHE PHE A . n A 1 101 MET 101 101 101 MET MET A . n A 1 102 GLN 102 102 102 GLN GLN A . n A 1 103 TRP 103 103 103 TRP TRP A . n A 1 104 GLY 104 104 104 GLY GLY A . n A 1 105 GLN 105 105 105 GLN GLN A . n A 1 106 ILE 106 106 106 ILE ILE A . n A 1 107 VAL 107 107 107 VAL VAL A . n A 1 108 ASP 108 108 108 ASP ASP A . n A 1 109 HIS 109 109 109 HIS HIS A . n A 1 110 ASP 110 110 110 ASP ASP A . n A 1 111 LEU 111 111 111 LEU LEU A . n A 1 112 ASP 112 112 112 ASP ASP A . n A 1 113 PHE 113 113 113 PHE PHE A . n A 1 114 ALA 114 114 114 ALA ALA A . n A 1 115 PRO 115 115 115 PRO PRO A . n A 1 116 GLU 116 116 116 GLU GLU A . n A 1 117 THR 117 117 117 THR THR A . n A 1 118 GLU 118 118 118 GLU GLU A . n A 1 119 LEU 119 119 119 LEU LEU A . n A 1 120 GLY 120 120 120 GLY GLY A . n A 1 121 SER 121 121 121 SER SER A . n A 1 122 ASN 122 122 122 ASN ASN A . n A 1 123 GLU 123 123 123 GLU GLU A . n A 1 124 HIS 124 124 124 HIS HIS A . n A 1 125 SER 125 125 125 SER SER A . n A 1 126 LYS 126 126 126 LYS LYS A . n A 1 127 THR 127 127 127 THR THR A . n A 1 128 GLN 128 128 128 GLN GLN A . n A 1 129 CYS 129 129 129 CYS CYS A . n A 1 130 GLU 130 130 130 GLU GLU A . n A 1 131 GLU 131 131 131 GLU GLU A . n A 1 132 TYR 132 132 132 TYR TYR A . n A 1 133 CYS 133 133 133 CYS CYS A . n A 1 134 ILE 134 134 134 ILE ILE A . n A 1 135 GLN 135 135 135 GLN GLN A . n A 1 136 GLY 136 136 136 GLY GLY A . n A 1 137 ASP 137 137 137 ASP ASP A . n A 1 138 ASN 138 138 138 ASN ASN A . n A 1 139 CYS 139 139 139 CYS CYS A . n A 1 140 PHE 140 140 140 PHE PHE A . n A 1 141 PRO 141 141 141 PRO PRO A . n A 1 142 ILE 142 142 142 ILE ILE A . n A 1 143 MET 143 143 143 MET MET A . n A 1 144 PHE 144 144 144 PHE PHE A . n A 1 145 PRO 145 145 145 PRO PRO A . n A 1 146 LYS 146 146 146 LYS LYS A . n A 1 147 ASN 147 147 147 ASN ASN A . n A 1 148 ASP 148 148 148 ASP ASP A . n A 1 149 PRO 149 149 149 PRO PRO A . n A 1 150 LYS 150 150 150 LYS LYS A . n A 1 151 LEU 151 151 151 LEU LEU A . n A 1 152 LYS 152 152 152 LYS LYS A . n A 1 153 THR 153 153 153 THR THR A . n A 1 154 GLN 154 154 154 GLN GLN A . n A 1 155 GLY 155 155 155 GLY GLY A . n A 1 156 LYS 156 156 156 LYS LYS A . n A 1 157 CYS 157 157 157 CYS CYS A . n A 1 158 MET 158 158 158 MET MET A . n A 1 159 PRO 159 159 159 PRO PRO A . n A 1 160 PHE 160 160 160 PHE PHE A . n A 1 161 PHE 161 161 161 PHE PHE A . n A 1 162 ARG 162 162 162 ARG ARG A . n A 1 163 ALA 163 163 163 ALA ALA A . n A 1 164 GLY 164 164 164 GLY GLY A . n A 1 165 PHE 165 165 165 PHE PHE A . n A 1 166 VAL 166 166 166 VAL VAL A . n A 1 167 CYS 167 167 167 CYS CYS A . n A 1 168 PRO 168 168 168 PRO PRO A . n A 1 169 THR 169 169 169 THR THR A . n A 1 170 PRO 170 170 170 PRO PRO A . n A 1 171 PRO 171 171 171 PRO PRO A . n A 1 172 TYR 172 172 172 TYR TYR A . n A 1 173 GLN 173 173 173 GLN GLN A . n A 1 174 SER 174 174 174 SER SER A . n A 1 175 LEU 175 175 175 LEU LEU A . n A 1 176 ALA 176 176 176 ALA ALA A . n A 1 177 ARG 177 177 177 ARG ARG A . n A 1 178 GLU 178 178 178 GLU GLU A . n A 1 179 GLN 179 179 179 GLN GLN A . n A 1 180 ILE 180 180 180 ILE ILE A . n A 1 181 ASN 181 181 181 ASN ASN A . n A 1 182 ALA 182 182 182 ALA ALA A . n A 1 183 VAL 183 183 183 VAL VAL A . n A 1 184 THR 184 184 184 THR THR A . n A 1 185 SER 185 185 185 SER SER A . n A 1 186 PHE 186 186 186 PHE PHE A . n A 1 187 LEU 187 187 187 LEU LEU A . n A 1 188 ASP 188 188 188 ASP ASP A . n A 1 189 ALA 189 189 189 ALA ALA A . n A 1 190 SER 190 190 190 SER SER A . n A 1 191 LEU 191 191 191 LEU LEU A . n A 1 192 VAL 192 192 192 VAL VAL A . n A 1 193 TYR 193 193 193 TYR TYR A . n A 1 194 GLY 194 194 194 GLY GLY A . n A 1 195 SER 195 195 195 SER SER A . n A 1 196 GLU 196 196 196 GLU GLU A . n A 1 197 PRO 197 197 197 PRO PRO A . n A 1 198 SEP 198 198 198 SEP SEP A . n A 1 199 LEU 199 199 199 LEU LEU A . n A 1 200 ALA 200 200 200 ALA ALA A . n A 1 201 SER 201 201 201 SER SER A . n A 1 202 ARG 202 202 202 ARG ARG A . n A 1 203 LEU 203 203 203 LEU LEU A . n A 1 204 ARG 204 204 204 ARG ARG A . n A 1 205 ASN 205 205 205 ASN ASN A . n A 1 206 LEU 206 206 206 LEU LEU A . n A 1 207 SER 207 207 207 SER SER A . n A 1 208 SER 208 208 208 SER SER A . n A 1 209 PRO 209 209 209 PRO PRO A . n A 1 210 LEU 210 210 210 LEU LEU A . n A 1 211 GLY 211 211 211 GLY GLY A . n A 1 212 LEU 212 212 212 LEU LEU A . n A 1 213 MET 213 213 213 MET MET A . n A 1 214 ALA 214 214 214 ALA ALA A . n A 1 215 VAL 215 215 215 VAL VAL A . n A 1 216 ASN 216 216 216 ASN ASN A . n A 1 217 GLN 217 217 217 GLN GLN A . n A 1 218 GLU 218 218 218 GLU GLU A . n A 1 219 ALA 219 219 219 ALA ALA A . n A 1 220 TRP 220 220 220 TRP TRP A . n A 1 221 ASP 221 221 221 ASP ASP A . n A 1 222 HIS 222 222 222 HIS HIS A . n A 1 223 GLY 223 223 223 GLY GLY A . n A 1 224 LEU 224 224 224 LEU LEU A . n A 1 225 ALA 225 225 225 ALA ALA A . n A 1 226 TYR 226 226 226 TYR TYR A . n A 1 227 LEU 227 227 227 LEU LEU A . n A 1 228 PRO 228 228 228 PRO PRO A . n A 1 229 PHE 229 229 229 PHE PHE A . n A 1 230 ASN 230 230 230 ASN ASN A . n A 1 231 ASN 231 231 231 ASN ASN A . n A 1 232 LYS 232 232 232 LYS LYS A . n A 1 233 LYS 233 233 233 LYS LYS A . n A 1 234 PRO 234 234 234 PRO PRO A . n A 1 235 SER 235 235 235 SER SER A . n A 1 236 PRO 236 236 236 PRO PRO A . n A 1 237 CYS 237 237 237 CYS CYS A . n A 1 238 GLU 238 238 238 GLU GLU A . n A 1 239 PHE 239 239 239 PHE PHE A . n A 1 240 ILE 240 240 240 ILE ILE A . n A 1 241 ASN 241 241 241 ASN ASN A . n A 1 242 THR 242 242 242 THR THR A . n A 1 243 THR 243 243 243 THR THR A . n A 1 244 ALA 244 244 244 ALA ALA A . n A 1 245 ARG 245 245 245 ARG ARG A . n A 1 246 VAL 246 246 246 VAL VAL A . n A 1 247 PRO 247 247 247 PRO PRO A . n A 1 248 CYS 248 248 248 CYS CYS A . n A 1 249 PHE 249 249 249 PHE PHE A . n A 1 250 LEU 250 250 250 LEU LEU A . n A 1 251 ALA 251 251 251 ALA ALA A . n A 1 252 GLY 252 252 252 GLY GLY A . n A 1 253 ASP 253 253 253 ASP ASP A . n A 1 254 PHE 254 254 254 PHE PHE A . n A 1 255 ARG 255 255 255 ARG ARG A . n A 1 256 ALA 256 256 256 ALA ALA A . n A 1 257 SER 257 257 257 SER SER A . n A 1 258 GLU 258 258 258 GLU GLU A . n A 1 259 GLN 259 259 259 GLN GLN A . n A 1 260 ILE 260 260 260 ILE ILE A . n A 1 261 LEU 261 261 261 LEU LEU A . n A 1 262 LEU 262 262 262 LEU LEU A . n A 1 263 ALA 263 263 263 ALA ALA A . n A 1 264 THR 264 264 264 THR THR A . n A 1 265 ALA 265 265 265 ALA ALA A . n A 1 266 HIS 266 266 266 HIS HIS A . n A 1 267 THR 267 267 267 THR THR A . n A 1 268 LEU 268 268 268 LEU LEU A . n A 1 269 LEU 269 269 269 LEU LEU A . n A 1 270 LEU 270 270 270 LEU LEU A . n A 1 271 ARG 271 271 271 ARG ARG A . n A 1 272 GLU 272 272 272 GLU GLU A . n A 1 273 HIS 273 273 273 HIS HIS A . n A 1 274 ASN 274 274 274 ASN ASN A . n A 1 275 ARG 275 275 275 ARG ARG A . n A 1 276 LEU 276 276 276 LEU LEU A . n A 1 277 ALA 277 277 277 ALA ALA A . n A 1 278 ARG 278 278 278 ARG ARG A . n A 1 279 GLU 279 279 279 GLU GLU A . n A 1 280 LEU 280 280 280 LEU LEU A . n A 1 281 LYS 281 281 281 LYS LYS A . n A 1 282 LYS 282 282 282 LYS LYS A . n A 1 283 LEU 283 283 283 LEU LEU A . n A 1 284 ASN 284 284 284 ASN ASN A . n A 1 285 PRO 285 285 285 PRO PRO A . n A 1 286 HIS 286 286 286 HIS HIS A . n A 1 287 TRP 287 287 287 TRP TRP A . n A 1 288 ASN 288 288 288 ASN ASN A . n A 1 289 GLY 289 289 289 GLY GLY A . n A 1 290 GLU 290 290 290 GLU GLU A . n A 1 291 LYS 291 291 291 LYS LYS A . n A 1 292 LEU 292 292 292 LEU LEU A . n A 1 293 TYR 293 293 293 TYR TYR A . n A 1 294 GLN 294 294 294 GLN GLN A . n A 1 295 GLU 295 295 295 GLU GLU A . n A 1 296 ALA 296 296 296 ALA ALA A . n A 1 297 ARG 297 297 297 ARG ARG A . n A 1 298 LYS 298 298 298 LYS LYS A . n A 1 299 ILE 299 299 299 ILE ILE A . n A 1 300 LEU 300 300 300 LEU LEU A . n A 1 301 GLY 301 301 301 GLY GLY A . n A 1 302 ALA 302 302 302 ALA ALA A . n A 1 303 PHE 303 303 303 PHE PHE A . n A 1 304 ILE 304 304 304 ILE ILE A . n A 1 305 GLN 305 305 305 GLN GLN A . n A 1 306 ILE 306 306 306 ILE ILE A . n A 1 307 ILE 307 307 307 ILE ILE A . n A 1 308 THR 308 308 308 THR THR A . n A 1 309 PHE 309 309 309 PHE PHE A . n A 1 310 ARG 310 310 310 ARG ARG A . n A 1 311 ASP 311 311 311 ASP ASP A . n A 1 312 TYR 312 312 312 TYR TYR A . n A 1 313 LEU 313 313 313 LEU LEU A . n A 1 314 PRO 314 314 314 PRO PRO A . n A 1 315 ILE 315 315 315 ILE ILE A . n A 1 316 VAL 316 316 316 VAL VAL A . n A 1 317 LEU 317 317 317 LEU LEU A . n A 1 318 GLY 318 318 318 GLY GLY A . n A 1 319 SER 319 319 319 SER SER A . n A 1 320 GLU 320 320 320 GLU GLU A . n A 1 321 MET 321 321 321 MET MET A . n A 1 322 GLN 322 322 322 GLN GLN A . n A 1 323 LYS 323 323 323 LYS LYS A . n A 1 324 TRP 324 324 324 TRP TRP A . n A 1 325 ILE 325 325 325 ILE ILE A . n A 1 326 PRO 326 326 326 PRO PRO A . n A 1 327 PRO 327 327 327 PRO PRO A . n A 1 328 TYR 328 328 328 TYR TYR A . n A 1 329 GLN 329 329 329 GLN GLN A . n A 1 330 GLY 330 330 330 GLY GLY A . n A 1 331 TYR 331 331 331 TYR TYR A . n A 1 332 ASN 332 332 332 ASN ASN A . n A 1 333 ASN 333 333 333 ASN ASN A . n A 1 334 SER 334 334 334 SER SER A . n A 1 335 VAL 335 335 335 VAL VAL A . n A 1 336 ASP 336 336 336 ASP ASP A . n A 1 337 PRO 337 337 337 PRO PRO A . n A 1 338 ARG 338 338 338 ARG ARG A . n A 1 339 ILE 339 339 339 ILE ILE A . n A 1 340 SER 340 340 340 SER SER A . n A 1 341 ASN 341 341 341 ASN ASN A . n A 1 342 VAL 342 342 342 VAL VAL A . n A 1 343 PHE 343 343 343 PHE PHE A . n A 1 344 THR 344 344 344 THR THR A . n A 1 345 PHE 345 345 345 PHE PHE A . n A 1 346 ALA 346 346 346 ALA ALA A . n A 1 347 PHE 347 347 347 PHE PHE A . n A 1 348 ARG 348 348 348 ARG ARG A . n A 1 349 PHE 349 349 349 PHE PHE A . n A 1 350 GLY 350 350 350 GLY GLY A . n A 1 351 HIS 351 351 351 HIS HIS A . n A 1 352 MET 352 352 352 MET MET A . n A 1 353 GLU 353 353 353 GLU GLU A . n A 1 354 VAL 354 354 354 VAL VAL A . n A 1 355 PRO 355 355 355 PRO PRO A . n A 1 356 SER 356 356 356 SER SER A . n A 1 357 THR 357 357 357 THR THR A . n A 1 358 VAL 358 358 358 VAL VAL A . n A 1 359 SER 359 359 359 SER SER A . n A 1 360 ARG 360 360 360 ARG ARG A . n A 1 361 LEU 361 361 361 LEU LEU A . n A 1 362 ASP 362 362 362 ASP ASP A . n A 1 363 GLU 363 363 363 GLU GLU A . n A 1 364 ASN 364 364 364 ASN ASN A . n A 1 365 TYR 365 365 365 TYR TYR A . n A 1 366 GLN 366 366 366 GLN GLN A . n A 1 367 PRO 367 367 367 PRO PRO A . n A 1 368 TRP 368 368 368 TRP TRP A . n A 1 369 GLY 369 369 369 GLY GLY A . n A 1 370 PRO 370 370 370 PRO PRO A . n A 1 371 GLU 371 371 371 GLU GLU A . n A 1 372 ALA 372 372 372 ALA ALA A . n A 1 373 GLU 373 373 373 GLU GLU A . n A 1 374 LEU 374 374 374 LEU LEU A . n A 1 375 PRO 375 375 375 PRO PRO A . n A 1 376 LEU 376 376 376 LEU LEU A . n A 1 377 HIS 377 377 377 HIS HIS A . n A 1 378 THR 378 378 378 THR THR A . n A 1 379 LEU 379 379 379 LEU LEU A . n A 1 380 PHE 380 380 380 PHE PHE A . n A 1 381 PHE 381 381 381 PHE PHE A . n A 1 382 ASN 382 382 382 ASN ASN A . n A 1 383 THR 383 383 383 THR THR A . n A 1 384 TRP 384 384 384 TRP TRP A . n A 1 385 ARG 385 385 385 ARG ARG A . n A 1 386 ILE 386 386 386 ILE ILE A . n A 1 387 ILE 387 387 387 ILE ILE A . n A 1 388 LYS 388 388 388 LYS LYS A . n A 1 389 ASP 389 389 389 ASP ASP A . n A 1 390 GLY 390 390 390 GLY GLY A . n A 1 391 GLY 391 391 391 GLY GLY A . n A 1 392 ILE 392 392 392 ILE ILE A . n A 1 393 ASP 393 393 393 ASP ASP A . n A 1 394 PRO 394 394 394 PRO PRO A . n A 1 395 LEU 395 395 395 LEU LEU A . n A 1 396 VAL 396 396 396 VAL VAL A . n A 1 397 ARG 397 397 397 ARG ARG A . n A 1 398 GLY 398 398 398 GLY GLY A . n A 1 399 LEU 399 399 399 LEU LEU A . n A 1 400 LEU 400 400 400 LEU LEU A . n A 1 401 ALA 401 401 401 ALA ALA A . n A 1 402 LYS 402 402 402 LYS LYS A . n A 1 403 LYS 403 403 403 LYS LYS A . n A 1 404 SER 404 404 404 SER SER A . n A 1 405 LYS 405 405 405 LYS LYS A . n A 1 406 LEU 406 406 406 LEU LEU A . n A 1 407 MET 407 407 407 MET MET A . n A 1 408 ASN 408 408 408 ASN ASN A . n A 1 409 GLN 409 409 409 GLN GLN A . n A 1 410 ASP 410 410 410 ASP ASP A . n A 1 411 LYS 411 411 411 LYS LYS A . n A 1 412 MET 412 412 412 MET MET A . n A 1 413 VAL 413 413 413 VAL VAL A . n A 1 414 THR 414 414 414 THR THR A . n A 1 415 SER 415 415 415 SER SER A . n A 1 416 GLU 416 416 416 GLU GLU A . n A 1 417 LEU 417 417 417 LEU LEU A . n A 1 418 ARG 418 418 418 ARG ARG A . n A 1 419 ASN 419 419 419 ASN ASN A . n A 1 420 LYS 420 420 420 LYS LYS A . n A 1 421 LEU 421 421 421 LEU LEU A . n A 1 422 PHE 422 422 422 PHE PHE A . n A 1 423 GLN 423 423 423 GLN GLN A . n A 1 424 PRO 424 424 424 PRO PRO A . n A 1 425 THR 425 425 425 THR THR A . n A 1 426 HIS 426 426 426 HIS HIS A . n A 1 427 LYS 427 427 427 LYS LYS A . n A 1 428 ILE 428 428 428 ILE ILE A . n A 1 429 HIS 429 429 429 HIS HIS A . n A 1 430 GLY 430 430 430 GLY GLY A . n A 1 431 PHE 431 431 431 PHE PHE A . n A 1 432 ASP 432 432 432 ASP ASP A . n A 1 433 LEU 433 433 433 LEU LEU A . n A 1 434 ALA 434 434 434 ALA ALA A . n A 1 435 ALA 435 435 435 ALA ALA A . n A 1 436 ILE 436 436 436 ILE ILE A . n A 1 437 ASN 437 437 437 ASN ASN A . n A 1 438 LEU 438 438 438 LEU LEU A . n A 1 439 GLN 439 439 439 GLN GLN A . n A 1 440 ARG 440 440 440 ARG ARG A . n A 1 441 CYS 441 441 441 CYS CYS A . n A 1 442 ARG 442 442 442 ARG ARG A . n A 1 443 ASP 443 443 443 ASP ASP A . n A 1 444 HIS 444 444 444 HIS HIS A . n A 1 445 GLY 445 445 445 GLY GLY A . n A 1 446 MET 446 446 446 MET MET A . n A 1 447 PRO 447 447 447 PRO PRO A . n A 1 448 GLY 448 448 448 GLY GLY A . n A 1 449 TYR 449 449 449 TYR TYR A . n A 1 450 ASN 450 450 450 ASN ASN A . n A 1 451 SER 451 451 451 SER SER A . n A 1 452 TRP 452 452 452 TRP TRP A . n A 1 453 ARG 453 453 453 ARG ARG A . n A 1 454 GLY 454 454 454 GLY GLY A . n A 1 455 PHE 455 455 455 PHE PHE A . n A 1 456 CYS 456 456 456 CYS CYS A . n A 1 457 GLY 457 457 457 GLY GLY A . n A 1 458 LEU 458 458 458 LEU LEU A . n A 1 459 SER 459 459 459 SER SER A . n A 1 460 GLN 460 460 460 GLN GLN A . n A 1 461 PRO 461 461 461 PRO PRO A . n A 1 462 LYS 462 462 462 LYS LYS A . n A 1 463 THR 463 463 463 THR THR A . n A 1 464 LEU 464 464 464 LEU LEU A . n A 1 465 LYS 465 465 465 LYS LYS A . n A 1 466 GLY 466 466 466 GLY GLY A . n A 1 467 LEU 467 467 467 LEU LEU A . n A 1 468 GLN 468 468 468 GLN GLN A . n A 1 469 THR 469 469 469 THR THR A . n A 1 470 VAL 470 470 470 VAL VAL A . n A 1 471 LEU 471 471 471 LEU LEU A . n A 1 472 LYS 472 472 472 LYS LYS A . n A 1 473 ASN 473 473 473 ASN ASN A . n A 1 474 LYS 474 474 474 LYS LYS A . n A 1 475 ILE 475 475 475 ILE ILE A . n A 1 476 LEU 476 476 476 LEU LEU A . n A 1 477 ALA 477 477 477 ALA ALA A . n A 1 478 LYS 478 478 478 LYS LYS A . n A 1 479 LYS 479 479 479 LYS LYS A . n A 1 480 LEU 480 480 480 LEU LEU A . n A 1 481 MET 481 481 481 MET MET A . n A 1 482 ASP 482 482 482 ASP ASP A . n A 1 483 LEU 483 483 483 LEU LEU A . n A 1 484 TYR 484 484 484 TYR TYR A . n A 1 485 LYS 485 485 485 LYS LYS A . n A 1 486 THR 486 486 486 THR THR A . n A 1 487 PRO 487 487 487 PRO PRO A . n A 1 488 ASP 488 488 488 ASP ASP A . n A 1 489 ASN 489 489 489 ASN ASN A . n A 1 490 ILE 490 490 490 ILE ILE A . n A 1 491 ASP 491 491 491 ASP ASP A . n A 1 492 ILE 492 492 492 ILE ILE A . n A 1 493 TRP 493 493 493 TRP TRP A . n A 1 494 ILE 494 494 494 ILE ILE A . n A 1 495 GLY 495 495 495 GLY GLY A . n A 1 496 GLY 496 496 496 GLY GLY A . n A 1 497 ASN 497 497 497 ASN ASN A . n A 1 498 ALA 498 498 498 ALA ALA A . n A 1 499 GLU 499 499 499 GLU GLU A . n A 1 500 PRO 500 500 500 PRO PRO A . n A 1 501 MET 501 501 501 MET MET A . n A 1 502 VAL 502 502 502 VAL VAL A . n A 1 503 GLU 503 503 503 GLU GLU A . n A 1 504 ARG 504 504 504 ARG ARG A . n A 1 505 GLY 505 505 505 GLY GLY A . n A 1 506 ARG 506 506 506 ARG ARG A . n A 1 507 VAL 507 507 507 VAL VAL A . n A 1 508 GLY 508 508 508 GLY GLY A . n A 1 509 PRO 509 509 509 PRO PRO A . n A 1 510 LEU 510 510 510 LEU LEU A . n A 1 511 LEU 511 511 511 LEU LEU A . n A 1 512 ALA 512 512 512 ALA ALA A . n A 1 513 CYS 513 513 513 CYS CYS A . n A 1 514 LEU 514 514 514 LEU LEU A . n A 1 515 LEU 515 515 515 LEU LEU A . n A 1 516 GLY 516 516 516 GLY GLY A . n A 1 517 ARG 517 517 517 ARG ARG A . n A 1 518 GLN 518 518 518 GLN GLN A . n A 1 519 PHE 519 519 519 PHE PHE A . n A 1 520 GLN 520 520 520 GLN GLN A . n A 1 521 GLN 521 521 521 GLN GLN A . n A 1 522 ILE 522 522 522 ILE ILE A . n A 1 523 ARG 523 523 523 ARG ARG A . n A 1 524 ASP 524 524 524 ASP ASP A . n A 1 525 GLY 525 525 525 GLY GLY A . n A 1 526 ASP 526 526 526 ASP ASP A . n A 1 527 ARG 527 527 527 ARG ARG A . n A 1 528 PHE 528 528 528 PHE PHE A . n A 1 529 TRP 529 529 529 TRP TRP A . n A 1 530 TRP 530 530 530 TRP TRP A . n A 1 531 GLU 531 531 531 GLU GLU A . n A 1 532 ASN 532 532 532 ASN ASN A . n A 1 533 PRO 533 533 533 PRO PRO A . n A 1 534 GLY 534 534 534 GLY GLY A . n A 1 535 VAL 535 535 535 VAL VAL A . n A 1 536 PHE 536 536 536 PHE PHE A . n A 1 537 THR 537 537 537 THR THR A . n A 1 538 GLU 538 538 538 GLU GLU A . n A 1 539 LYS 539 539 539 LYS LYS A . n A 1 540 GLN 540 540 540 GLN GLN A . n A 1 541 ARG 541 541 541 ARG ARG A . n A 1 542 ASP 542 542 542 ASP ASP A . n A 1 543 SER 543 543 543 SER SER A . n A 1 544 LEU 544 544 544 LEU LEU A . n A 1 545 GLN 545 545 545 GLN GLN A . n A 1 546 LYS 546 546 546 LYS LYS A . n A 1 547 VAL 547 547 547 VAL VAL A . n A 1 548 SER 548 548 548 SER SER A . n A 1 549 PHE 549 549 549 PHE PHE A . n A 1 550 SER 550 550 550 SER SER A . n A 1 551 ARG 551 551 551 ARG ARG A . n A 1 552 LEU 552 552 552 LEU LEU A . n A 1 553 ILE 553 553 553 ILE ILE A . n A 1 554 CYS 554 554 554 CYS CYS A . n A 1 555 ASP 555 555 555 ASP ASP A . n A 1 556 ASN 556 556 556 ASN ASN A . n A 1 557 THR 557 557 557 THR THR A . n A 1 558 HIS 558 558 558 HIS HIS A . n A 1 559 ILE 559 559 559 ILE ILE A . n A 1 560 THR 560 560 560 THR THR A . n A 1 561 LYS 561 561 561 LYS LYS A . n A 1 562 VAL 562 562 562 VAL VAL A . n A 1 563 PRO 563 563 563 PRO PRO A . n A 1 564 LEU 564 564 564 LEU LEU A . n A 1 565 HIS 565 565 565 HIS HIS A . n A 1 566 ALA 566 566 566 ALA ALA A . n A 1 567 PHE 567 567 567 PHE PHE A . n A 1 568 GLN 568 568 568 GLN GLN A . n A 1 569 ALA 569 569 569 ALA ALA A . n A 1 570 ASN 570 570 570 ASN ASN A . n A 1 571 ASN 571 571 571 ASN ASN A . n A 1 572 TYR 572 572 572 TYR TYR A . n A 1 573 PRO 573 573 573 PRO PRO A . n A 1 574 HIS 574 574 574 HIS HIS A . n A 1 575 ASP 575 575 575 ASP ASP A . n A 1 576 PHE 576 576 576 PHE PHE A . n A 1 577 VAL 577 577 577 VAL VAL A . n A 1 578 ASP 578 578 578 ASP ASP A . n A 1 579 CYS 579 579 579 CYS CYS A . n A 1 580 SER 580 580 580 SER SER A . n A 1 581 THR 581 581 581 THR THR A . n A 1 582 VAL 582 582 582 VAL VAL A . n A 1 583 ASP 583 583 583 ASP ASP A . n A 1 584 LYS 584 584 584 LYS LYS A . n A 1 585 LEU 585 585 585 LEU LEU A . n A 1 586 ASP 586 586 586 ASP ASP A . n A 1 587 LEU 587 587 587 LEU LEU A . n A 1 588 SER 588 588 588 SER SER A . n A 1 589 PRO 589 589 589 PRO PRO A . n A 1 590 TRP 590 590 590 TRP TRP A . n A 1 591 ALA 591 591 591 ALA ALA A . n A 1 592 SER 592 592 592 SER SER A . n A 1 593 ARG 593 593 593 ARG ARG A . n A 1 594 GLU 594 594 594 GLU GLU A . n A 1 595 ASN 595 595 595 ASN ASN A . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code B 2 CA 1 601 606 CA CA A . C 3 HEM 1 602 605 HEM HEM A . D 4 NAG 1 603 596 NAG NAG A . E 4 NAG 1 604 599 NAG NAG A . F 4 NAG 1 605 601 NAG NAG A . G 4 NAG 1 606 604 NAG NAG A . H 5 BMM 1 607 2057 BMM BMM A . I 6 IOD 1 608 1 IOD IOD A . J 6 IOD 1 609 1 IOD IOD A . K 6 IOD 1 610 1 IOD IOD A . L 6 IOD 1 611 1 IOD IOD A . M 6 IOD 1 612 1 IOD IOD A . N 6 IOD 1 613 1 IOD IOD A . O 6 IOD 1 614 1 IOD IOD A . P 6 IOD 1 615 1 IOD IOD A . Q 6 IOD 1 616 1 IOD IOD A . R 6 IOD 1 617 1 IOD IOD A . S 6 IOD 1 618 1 IOD IOD A . T 6 IOD 1 619 1 IOD IOD A . U 6 IOD 1 620 1 IOD IOD A . V 7 HOH 1 701 1 HOH HOH A . V 7 HOH 2 702 2 HOH HOH A . V 7 HOH 3 703 7 HOH HOH A . V 7 HOH 4 704 8 HOH HOH A . V 7 HOH 5 705 9 HOH HOH A . V 7 HOH 6 706 11 HOH HOH A . V 7 HOH 7 707 13 HOH HOH A . V 7 HOH 8 708 14 HOH HOH A . V 7 HOH 9 709 18 HOH HOH A . V 7 HOH 10 710 19 HOH HOH A . V 7 HOH 11 711 20 HOH HOH A . V 7 HOH 12 712 21 HOH HOH A . V 7 HOH 13 713 24 HOH HOH A . V 7 HOH 14 714 27 HOH HOH A . V 7 HOH 15 715 29 HOH HOH A . V 7 HOH 16 716 30 HOH HOH A . V 7 HOH 17 717 32 HOH HOH A . V 7 HOH 18 718 33 HOH HOH A . V 7 HOH 19 719 35 HOH HOH A . V 7 HOH 20 720 43 HOH HOH A . V 7 HOH 21 721 46 HOH HOH A . V 7 HOH 22 722 48 HOH HOH A . V 7 HOH 23 723 50 HOH HOH A . V 7 HOH 24 724 51 HOH HOH A . V 7 HOH 25 725 53 HOH HOH A . V 7 HOH 26 726 56 HOH HOH A . V 7 HOH 27 727 57 HOH HOH A . V 7 HOH 28 728 59 HOH HOH A . V 7 HOH 29 729 60 HOH HOH A . V 7 HOH 30 730 62 HOH HOH A . V 7 HOH 31 731 65 HOH HOH A . V 7 HOH 32 732 66 HOH HOH A . V 7 HOH 33 733 68 HOH HOH A . V 7 HOH 34 734 71 HOH HOH A . V 7 HOH 35 735 79 HOH HOH A . V 7 HOH 36 736 82 HOH HOH A . V 7 HOH 37 737 85 HOH HOH A . V 7 HOH 38 738 86 HOH HOH A . V 7 HOH 39 739 96 HOH HOH A . V 7 HOH 40 740 100 HOH HOH A . V 7 HOH 41 741 129 HOH HOH A . V 7 HOH 42 742 151 HOH HOH A . V 7 HOH 43 743 188 HOH HOH A . V 7 HOH 44 744 196 HOH HOH A . V 7 HOH 45 745 221 HOH HOH A . V 7 HOH 46 746 258 HOH HOH A . V 7 HOH 47 747 262 HOH HOH A . V 7 HOH 48 748 264 HOH HOH A . V 7 HOH 49 749 10 HOH HOH A . V 7 HOH 50 750 17 HOH HOH A . V 7 HOH 51 751 26 HOH HOH A . V 7 HOH 52 752 30 HOH HOH A . V 7 HOH 53 753 46 HOH HOH A . V 7 HOH 54 754 64 HOH HOH A . V 7 HOH 55 755 77 HOH HOH A . V 7 HOH 56 756 92 HOH HOH A . V 7 HOH 57 757 94 HOH HOH A . V 7 HOH 58 758 124 HOH HOH A . V 7 HOH 59 759 129 HOH HOH A . V 7 HOH 60 760 138 HOH HOH A . V 7 HOH 61 761 214 HOH HOH A . V 7 HOH 62 762 217 HOH HOH A . V 7 HOH 63 763 1 HOH HOH A . V 7 HOH 64 764 3 HOH HOH A . V 7 HOH 65 765 16 HOH HOH A . V 7 HOH 66 766 36 HOH HOH A . V 7 HOH 67 767 76 HOH HOH A . V 7 HOH 68 768 112 HOH HOH A . V 7 HOH 69 769 185 HOH HOH A . V 7 HOH 70 770 196 HOH HOH A . V 7 HOH 71 771 219 HOH HOH A . V 7 HOH 72 772 1 HOH HOH A . V 7 HOH 73 773 4 HOH HOH A . V 7 HOH 74 774 19 HOH HOH A . V 7 HOH 75 775 54 HOH HOH A . V 7 HOH 76 776 93 HOH HOH A . V 7 HOH 77 777 125 HOH HOH A . V 7 HOH 78 778 205 HOH HOH A . V 7 HOH 79 779 1 HOH HOH A . V 7 HOH 80 780 31 HOH HOH A . V 7 HOH 81 781 69 HOH HOH A . V 7 HOH 82 782 172 HOH HOH A . V 7 HOH 83 783 205 HOH HOH A . V 7 HOH 84 784 207 HOH HOH A . V 7 HOH 85 785 4 HOH HOH A . V 7 HOH 86 786 28 HOH HOH A . V 7 HOH 87 787 31 HOH HOH A . V 7 HOH 88 788 33 HOH HOH A . V 7 HOH 89 789 83 HOH HOH A . V 7 HOH 90 790 93 HOH HOH A . V 7 HOH 91 791 106 HOH HOH A . V 7 HOH 92 792 134 HOH HOH A . V 7 HOH 93 793 12 HOH HOH A . V 7 HOH 94 794 21 HOH HOH A . V 7 HOH 95 795 59 HOH HOH A . V 7 HOH 96 796 30 HOH HOH A . V 7 HOH 97 797 143 HOH HOH A . V 7 HOH 98 798 171 HOH HOH A . V 7 HOH 99 799 213 HOH HOH A . V 7 HOH 100 800 2 HOH HOH A . V 7 HOH 101 801 56 HOH HOH A . V 7 HOH 102 802 76 HOH HOH A . V 7 HOH 103 803 48 HOH HOH A . V 7 HOH 104 804 37 HOH HOH A . V 7 HOH 105 805 175 HOH HOH A . V 7 HOH 106 806 11 HOH HOH A . V 7 HOH 107 807 4 HOH HOH A . V 7 HOH 108 808 10 HOH HOH A . V 7 HOH 109 809 112 HOH HOH A . V 7 HOH 110 810 155 HOH HOH A . V 7 HOH 111 811 1 HOH HOH A . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 205 A ASN 205 ? ASN 'GLYCOSYLATION SITE' 2 A SEP 198 A SEP 198 ? SER PHOSPHOSERINE # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_and_software_defined_assembly _pdbx_struct_assembly.method_details PISA _pdbx_struct_assembly.oligomeric_details monomeric _pdbx_struct_assembly.oligomeric_count 1 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # loop_ _pdbx_struct_conn_angle.id _pdbx_struct_conn_angle.ptnr1_label_atom_id _pdbx_struct_conn_angle.ptnr1_label_alt_id _pdbx_struct_conn_angle.ptnr1_label_asym_id _pdbx_struct_conn_angle.ptnr1_label_comp_id _pdbx_struct_conn_angle.ptnr1_label_seq_id _pdbx_struct_conn_angle.ptnr1_auth_atom_id _pdbx_struct_conn_angle.ptnr1_auth_asym_id _pdbx_struct_conn_angle.ptnr1_auth_comp_id _pdbx_struct_conn_angle.ptnr1_auth_seq_id _pdbx_struct_conn_angle.ptnr1_PDB_ins_code _pdbx_struct_conn_angle.ptnr1_symmetry _pdbx_struct_conn_angle.ptnr2_label_atom_id _pdbx_struct_conn_angle.ptnr2_label_alt_id _pdbx_struct_conn_angle.ptnr2_label_asym_id _pdbx_struct_conn_angle.ptnr2_label_comp_id _pdbx_struct_conn_angle.ptnr2_label_seq_id _pdbx_struct_conn_angle.ptnr2_auth_atom_id _pdbx_struct_conn_angle.ptnr2_auth_asym_id _pdbx_struct_conn_angle.ptnr2_auth_comp_id _pdbx_struct_conn_angle.ptnr2_auth_seq_id _pdbx_struct_conn_angle.ptnr2_PDB_ins_code _pdbx_struct_conn_angle.ptnr2_symmetry _pdbx_struct_conn_angle.ptnr3_label_atom_id _pdbx_struct_conn_angle.ptnr3_label_alt_id _pdbx_struct_conn_angle.ptnr3_label_asym_id _pdbx_struct_conn_angle.ptnr3_label_comp_id _pdbx_struct_conn_angle.ptnr3_label_seq_id _pdbx_struct_conn_angle.ptnr3_auth_atom_id _pdbx_struct_conn_angle.ptnr3_auth_asym_id _pdbx_struct_conn_angle.ptnr3_auth_comp_id _pdbx_struct_conn_angle.ptnr3_auth_seq_id _pdbx_struct_conn_angle.ptnr3_PDB_ins_code _pdbx_struct_conn_angle.ptnr3_symmetry _pdbx_struct_conn_angle.value _pdbx_struct_conn_angle.value_esd 1 O ? A PHE 186 ? A PHE 186 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 OD1 ? A ASP 110 ? A ASP 110 ? 1_555 82.8 ? 2 O ? A PHE 186 ? A PHE 186 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 OG1 ? A THR 184 ? A THR 184 ? 1_555 99.5 ? 3 OD1 ? A ASP 110 ? A ASP 110 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 OG1 ? A THR 184 ? A THR 184 ? 1_555 151.1 ? 4 O ? A PHE 186 ? A PHE 186 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 O ? A ASP 110 ? A ASP 110 ? 1_555 119.0 ? 5 OD1 ? A ASP 110 ? A ASP 110 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 O ? A ASP 110 ? A ASP 110 ? 1_555 71.2 ? 6 OG1 ? A THR 184 ? A THR 184 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 O ? A ASP 110 ? A ASP 110 ? 1_555 128.9 ? 7 O ? A PHE 186 ? A PHE 186 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 O ? A THR 184 ? A THR 184 ? 1_555 92.1 ? 8 OD1 ? A ASP 110 ? A ASP 110 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 O ? A THR 184 ? A THR 184 ? 1_555 138.9 ? 9 OG1 ? A THR 184 ? A THR 184 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 O ? A THR 184 ? A THR 184 ? 1_555 70.0 ? 10 O ? A ASP 110 ? A ASP 110 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 O ? A THR 184 ? A THR 184 ? 1_555 76.0 ? 11 O ? A PHE 186 ? A PHE 186 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 OD1 ? A ASP 188 ? A ASP 188 ? 1_555 78.8 ? 12 OD1 ? A ASP 110 ? A ASP 110 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 OD1 ? A ASP 188 ? A ASP 188 ? 1_555 78.6 ? 13 OG1 ? A THR 184 ? A THR 184 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 OD1 ? A ASP 188 ? A ASP 188 ? 1_555 73.8 ? 14 O ? A ASP 110 ? A ASP 110 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 OD1 ? A ASP 188 ? A ASP 188 ? 1_555 141.6 ? 15 O ? A THR 184 ? A THR 184 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 OD1 ? A ASP 188 ? A ASP 188 ? 1_555 140.5 ? 16 O ? A PHE 186 ? A PHE 186 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 OG ? A SER 190 ? A SER 190 ? 1_555 152.1 ? 17 OD1 ? A ASP 110 ? A ASP 110 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 OG ? A SER 190 ? A SER 190 ? 1_555 88.2 ? 18 OG1 ? A THR 184 ? A THR 184 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 OG ? A SER 190 ? A SER 190 ? 1_555 76.3 ? 19 O ? A ASP 110 ? A ASP 110 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 OG ? A SER 190 ? A SER 190 ? 1_555 82.3 ? 20 O ? A THR 184 ? A THR 184 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 OG ? A SER 190 ? A SER 190 ? 1_555 111.5 ? 21 OD1 ? A ASP 188 ? A ASP 188 ? 1_555 CA ? B CA . ? A CA 601 ? 1_555 OG ? A SER 190 ? A SER 190 ? 1_555 73.5 ? 22 NE2 ? A HIS 351 ? A HIS 351 ? 1_555 FE ? C HEM . ? A HEM 602 ? 1_555 NA ? C HEM . ? A HEM 602 ? 1_555 98.5 ? 23 NE2 ? A HIS 351 ? A HIS 351 ? 1_555 FE ? C HEM . ? A HEM 602 ? 1_555 NB ? C HEM . ? A HEM 602 ? 1_555 98.1 ? 24 NA ? C HEM . ? A HEM 602 ? 1_555 FE ? C HEM . ? A HEM 602 ? 1_555 NB ? C HEM . ? A HEM 602 ? 1_555 90.6 ? 25 NE2 ? A HIS 351 ? A HIS 351 ? 1_555 FE ? C HEM . ? A HEM 602 ? 1_555 NC ? C HEM . ? A HEM 602 ? 1_555 81.7 ? 26 NA ? C HEM . ? A HEM 602 ? 1_555 FE ? C HEM . ? A HEM 602 ? 1_555 NC ? C HEM . ? A HEM 602 ? 1_555 178.5 ? 27 NB ? C HEM . ? A HEM 602 ? 1_555 FE ? C HEM . ? A HEM 602 ? 1_555 NC ? C HEM . ? A HEM 602 ? 1_555 88.0 ? 28 NE2 ? A HIS 351 ? A HIS 351 ? 1_555 FE ? C HEM . ? A HEM 602 ? 1_555 ND ? C HEM . ? A HEM 602 ? 1_555 79.4 ? 29 NA ? C HEM . ? A HEM 602 ? 1_555 FE ? C HEM . ? A HEM 602 ? 1_555 ND ? C HEM . ? A HEM 602 ? 1_555 90.0 ? 30 NB ? C HEM . ? A HEM 602 ? 1_555 FE ? C HEM . ? A HEM 602 ? 1_555 ND ? C HEM . ? A HEM 602 ? 1_555 177.4 ? 31 NC ? C HEM . ? A HEM 602 ? 1_555 FE ? C HEM . ? A HEM 602 ? 1_555 ND ? C HEM . ? A HEM 602 ? 1_555 91.4 ? # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2014-03-12 2 'Structure model' 1 1 2017-02-22 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # _pdbx_audit_revision_group.ordinal 1 _pdbx_audit_revision_group.revision_ordinal 2 _pdbx_audit_revision_group.data_content_type 'Structure model' _pdbx_audit_revision_group.group 'Database references' # _software.name REFMAC _software.classification refinement _software.version 5.5.0109 _software.citation_id ? _software.pdbx_ordinal 1 # loop_ _pdbx_validate_close_contact.id _pdbx_validate_close_contact.PDB_model_num _pdbx_validate_close_contact.auth_atom_id_1 _pdbx_validate_close_contact.auth_asym_id_1 _pdbx_validate_close_contact.auth_comp_id_1 _pdbx_validate_close_contact.auth_seq_id_1 _pdbx_validate_close_contact.PDB_ins_code_1 _pdbx_validate_close_contact.label_alt_id_1 _pdbx_validate_close_contact.auth_atom_id_2 _pdbx_validate_close_contact.auth_asym_id_2 _pdbx_validate_close_contact.auth_comp_id_2 _pdbx_validate_close_contact.auth_seq_id_2 _pdbx_validate_close_contact.PDB_ins_code_2 _pdbx_validate_close_contact.label_alt_id_2 _pdbx_validate_close_contact.dist 1 1 O A ASN 30 ? ? O A SER 33 ? ? 1.71 2 1 OD1 A ASP 108 ? ? CMD A HEM 602 ? ? 1.98 3 1 OD2 A ASP 108 ? ? CMD A HEM 602 ? ? 2.07 # loop_ _pdbx_validate_rmsd_bond.id _pdbx_validate_rmsd_bond.PDB_model_num _pdbx_validate_rmsd_bond.auth_atom_id_1 _pdbx_validate_rmsd_bond.auth_asym_id_1 _pdbx_validate_rmsd_bond.auth_comp_id_1 _pdbx_validate_rmsd_bond.auth_seq_id_1 _pdbx_validate_rmsd_bond.PDB_ins_code_1 _pdbx_validate_rmsd_bond.label_alt_id_1 _pdbx_validate_rmsd_bond.auth_atom_id_2 _pdbx_validate_rmsd_bond.auth_asym_id_2 _pdbx_validate_rmsd_bond.auth_comp_id_2 _pdbx_validate_rmsd_bond.auth_seq_id_2 _pdbx_validate_rmsd_bond.PDB_ins_code_2 _pdbx_validate_rmsd_bond.label_alt_id_2 _pdbx_validate_rmsd_bond.bond_value _pdbx_validate_rmsd_bond.bond_target_value _pdbx_validate_rmsd_bond.bond_deviation _pdbx_validate_rmsd_bond.bond_standard_deviation _pdbx_validate_rmsd_bond.linker_flag 1 1 CD A PRO 34 ? ? N A PRO 34 ? ? 1.806 1.474 0.332 0.014 N 2 1 CD A PRO 168 ? ? N A PRO 168 ? ? 1.829 1.474 0.355 0.014 N # loop_ _pdbx_validate_rmsd_angle.id _pdbx_validate_rmsd_angle.PDB_model_num _pdbx_validate_rmsd_angle.auth_atom_id_1 _pdbx_validate_rmsd_angle.auth_asym_id_1 _pdbx_validate_rmsd_angle.auth_comp_id_1 _pdbx_validate_rmsd_angle.auth_seq_id_1 _pdbx_validate_rmsd_angle.PDB_ins_code_1 _pdbx_validate_rmsd_angle.label_alt_id_1 _pdbx_validate_rmsd_angle.auth_atom_id_2 _pdbx_validate_rmsd_angle.auth_asym_id_2 _pdbx_validate_rmsd_angle.auth_comp_id_2 _pdbx_validate_rmsd_angle.auth_seq_id_2 _pdbx_validate_rmsd_angle.PDB_ins_code_2 _pdbx_validate_rmsd_angle.label_alt_id_2 _pdbx_validate_rmsd_angle.auth_atom_id_3 _pdbx_validate_rmsd_angle.auth_asym_id_3 _pdbx_validate_rmsd_angle.auth_comp_id_3 _pdbx_validate_rmsd_angle.auth_seq_id_3 _pdbx_validate_rmsd_angle.PDB_ins_code_3 _pdbx_validate_rmsd_angle.label_alt_id_3 _pdbx_validate_rmsd_angle.angle_value _pdbx_validate_rmsd_angle.angle_target_value _pdbx_validate_rmsd_angle.angle_deviation _pdbx_validate_rmsd_angle.angle_standard_deviation _pdbx_validate_rmsd_angle.linker_flag 1 1 CB A TRP 2 ? ? CA A TRP 2 ? ? C A TRP 2 ? ? 92.24 110.40 -18.16 2.00 N 2 1 N A TRP 2 ? ? CA A TRP 2 ? ? C A TRP 2 ? ? 86.07 111.00 -24.93 2.70 N 3 1 N A GLY 7 ? ? CA A GLY 7 ? ? C A GLY 7 ? ? 97.29 113.10 -15.81 2.50 N 4 1 C A VAL 10 ? ? N A PRO 11 ? ? CA A PRO 11 ? ? 128.40 119.30 9.10 1.50 Y 5 1 C A SER 33 ? ? N A PRO 34 ? ? CD A PRO 34 ? ? 109.08 128.40 -19.32 2.10 Y 6 1 CA A PRO 34 ? ? N A PRO 34 ? ? CD A PRO 34 ? ? 96.08 111.70 -15.62 1.40 N 7 1 N A PRO 34 ? ? CA A PRO 34 ? ? CB A PRO 34 ? ? 114.46 103.30 11.16 1.20 N 8 1 CB A PHE 113 ? ? CA A PHE 113 ? ? C A PHE 113 ? ? 130.59 110.40 20.19 2.00 N 9 1 N A PHE 113 ? ? CA A PHE 113 ? ? C A PHE 113 ? ? 89.82 111.00 -21.18 2.70 N 10 1 N A SER 121 ? ? CA A SER 121 ? ? CB A SER 121 ? ? 90.54 110.50 -19.96 1.50 N 11 1 N A CYS 167 ? ? CA A CYS 167 ? ? C A CYS 167 ? ? 90.70 111.00 -20.30 2.70 N 12 1 CA A PRO 168 ? ? N A PRO 168 ? ? CD A PRO 168 ? ? 93.81 111.70 -17.89 1.40 N 13 1 N A PRO 168 ? ? CA A PRO 168 ? ? C A PRO 168 ? ? 95.41 112.10 -16.69 2.60 N 14 1 N A PRO 170 ? ? CA A PRO 170 ? ? C A PRO 170 ? ? 129.97 112.10 17.87 2.60 N 15 1 C A PRO 170 ? ? N A PRO 171 ? ? CD A PRO 171 ? ? 109.41 128.40 -18.99 2.10 Y 16 1 N A SER 208 ? ? CA A SER 208 ? ? CB A SER 208 ? ? 96.14 110.50 -14.36 1.50 N 17 1 CB A LEU 283 ? ? CA A LEU 283 ? ? C A LEU 283 ? ? 128.58 110.20 18.38 1.90 N 18 1 N A HIS 426 ? ? CA A HIS 426 ? ? CB A HIS 426 ? ? 122.68 110.60 12.08 1.80 N 19 1 N A HIS 426 ? ? CA A HIS 426 ? ? C A HIS 426 ? ? 93.49 111.00 -17.51 2.70 N 20 1 CB A LYS 485 ? ? CA A LYS 485 ? ? C A LYS 485 ? ? 91.04 110.40 -19.36 2.00 N 21 1 CB A VAL 547 ? ? CA A VAL 547 ? ? C A VAL 547 ? ? 93.01 111.40 -18.39 1.90 N 22 1 CB A CYS 579 ? ? CA A CYS 579 ? ? C A CYS 579 ? ? 127.63 111.50 16.13 1.20 N # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 GLU A 3 ? ? -78.73 -167.39 2 1 LEU A 12 ? ? 84.20 101.06 3 1 ASN A 18 ? ? -67.50 74.77 4 1 CYS A 28 ? ? 89.64 15.71 5 1 ALA A 56 ? ? 172.40 70.22 6 1 ASN A 122 ? ? -152.40 67.36 7 1 LYS A 126 ? ? -53.82 -70.38 8 1 GLN A 154 ? ? -130.14 -39.58 9 1 CYS A 167 ? ? 74.47 -135.14 10 1 THR A 169 ? ? -161.43 -34.80 11 1 GLN A 173 ? ? -167.22 21.51 12 1 SER A 208 ? ? 146.87 150.23 13 1 ALA A 214 ? ? -49.51 108.94 14 1 ASN A 241 ? ? -168.54 83.54 15 1 HIS A 273 ? ? -48.71 -71.31 16 1 LYS A 282 ? ? -63.82 13.09 17 1 LEU A 283 ? ? -126.70 -59.90 18 1 ASN A 333 ? ? -58.68 -6.62 19 1 ARG A 348 ? ? -68.36 6.79 20 1 PRO A 367 ? ? -41.06 96.06 21 1 LYS A 485 ? ? 53.12 5.05 22 1 TRP A 530 ? ? -36.50 -35.42 23 1 GLN A 545 ? ? -58.24 -6.74 24 1 HIS A 565 ? ? -105.94 77.80 25 1 PRO A 589 ? ? -54.04 -9.10 # loop_ _pdbx_validate_peptide_omega.id _pdbx_validate_peptide_omega.PDB_model_num _pdbx_validate_peptide_omega.auth_comp_id_1 _pdbx_validate_peptide_omega.auth_asym_id_1 _pdbx_validate_peptide_omega.auth_seq_id_1 _pdbx_validate_peptide_omega.PDB_ins_code_1 _pdbx_validate_peptide_omega.label_alt_id_1 _pdbx_validate_peptide_omega.auth_comp_id_2 _pdbx_validate_peptide_omega.auth_asym_id_2 _pdbx_validate_peptide_omega.auth_seq_id_2 _pdbx_validate_peptide_omega.PDB_ins_code_2 _pdbx_validate_peptide_omega.label_alt_id_2 _pdbx_validate_peptide_omega.omega 1 1 TRP A 2 ? ? GLU A 3 ? ? -147.97 2 1 GLY A 7 ? ? ALA A 8 ? ? 147.90 3 1 CYS A 167 ? ? PRO A 168 ? ? -143.62 4 1 PRO A 170 ? ? PRO A 171 ? ? 146.51 # _pdbx_validate_main_chain_plane.id 1 _pdbx_validate_main_chain_plane.PDB_model_num 1 _pdbx_validate_main_chain_plane.auth_comp_id LEU _pdbx_validate_main_chain_plane.auth_asym_id A _pdbx_validate_main_chain_plane.auth_seq_id 206 _pdbx_validate_main_chain_plane.PDB_ins_code ? _pdbx_validate_main_chain_plane.label_alt_id ? _pdbx_validate_main_chain_plane.improper_torsion_angle -10.59 # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 N 1 A NAG 603 ? O1 ? D NAG 1 O1 2 1 N 1 A NAG 605 ? O1 ? F NAG 1 O1 3 1 N 1 A NAG 606 ? O1 ? G NAG 1 O1 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 'CALCIUM ION' CA 3 'PROTOPORPHYRIN IX CONTAINING FE' HEM 4 N-ACETYL-D-GLUCOSAMINE NAG 5 BROMOMETHANE BMM 6 'IODIDE ION' IOD 7 water HOH #