data_4GT0 # _entry.id 4GT0 # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.287 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 4GT0 RCSB RCSB074595 WWPDB D_1000074595 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.details _pdbx_database_related.content_type PDB 3G7T . unspecified PDB 1OK8 . unspecified PDB 1URZ . unspecified PDB 4GSX . unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 4GT0 _pdbx_database_status.recvd_initial_deposition_date 2012-08-28 _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry ? _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? _pdbx_database_status.pdb_format_compatible Y # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Klein, D.E.' 1 'Choi, J.L.' 2 'Harrison, S.C.' 3 # _citation.id primary _citation.title 'Structure of a dengue virus envelope protein late-stage fusion intermediate.' _citation.journal_abbrev J.Virol. _citation.journal_volume 87 _citation.page_first 2287 _citation.page_last 2293 _citation.year 2013 _citation.journal_id_ASTM JOVIAM _citation.country US _citation.journal_id_ISSN 0022-538X _citation.journal_id_CSD 0825 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 23236058 _citation.pdbx_database_id_DOI 10.1128/JVI.02957-12 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Klein, D.E.' 1 primary 'Choi, J.L.' 2 primary 'Harrison, S.C.' 3 # _cell.entry_id 4GT0 _cell.length_a 77.893 _cell.length_b 77.893 _cell.length_c 292.291 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 120.00 _cell.Z_PDB 12 _cell.pdbx_unique_axis ? _cell.length_a_esd ? _cell.length_b_esd ? _cell.length_c_esd ? _cell.angle_alpha_esd ? _cell.angle_beta_esd ? _cell.angle_gamma_esd ? # _symmetry.entry_id 4GT0 _symmetry.space_group_name_H-M 'P 63' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 173 _symmetry.space_group_name_Hall ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'Envelope protein E' 47870.391 2 ? W101H 'sE(421), UNP residues 281-701' ? 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 2 ? ? ? ? 3 non-polymer syn 'CADMIUM ION' 112.411 4 ? ? ? ? 4 non-polymer syn 'CHLORIDE ION' 35.453 1 ? ? ? ? 5 water nat water 18.015 223 ? ? ? ? # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;GHHHHHHHHGSSTSNGMRCVGIGNRDFVEGLSGATWVDVVLEHGSCVTTMAKDKPTLDIELLKTEVTNPAVLRKLCIEAK ISNTTTDSRCPTQGEATLVEEQDTNFVCRRTFVDRGHGNGCGLFGKGSLITCAKFKCVTKLEGKIVQYENLKYSVIVTVH TGDQHQVGNETTEHGTIATITPQAPTSEIQLTDYGALTLDCSPRTGLDFNEMVLLTMKEKSWLVHKQWFLDLPLPWTSGA STSQETWNRQDLLVTFKTAHAKKQEVVVLGSQEGAMHTALTGATEIQTSGTTTIFAGHLKCRLKMDKLTLKGMSYVMCTG SFKLEKEVAETQHGTVLVQVKYEGTDAPCKIPFSSQDEKGVTQNGRLITANPIVTDKEKPVNIEAEPPFGESYIVVGAGE KALKLSWFKKGSSIGKMFEATARGARRMAILGDTAWD ; _entity_poly.pdbx_seq_one_letter_code_can ;GHHHHHHHHGSSTSNGMRCVGIGNRDFVEGLSGATWVDVVLEHGSCVTTMAKDKPTLDIELLKTEVTNPAVLRKLCIEAK ISNTTTDSRCPTQGEATLVEEQDTNFVCRRTFVDRGHGNGCGLFGKGSLITCAKFKCVTKLEGKIVQYENLKYSVIVTVH TGDQHQVGNETTEHGTIATITPQAPTSEIQLTDYGALTLDCSPRTGLDFNEMVLLTMKEKSWLVHKQWFLDLPLPWTSGA STSQETWNRQDLLVTFKTAHAKKQEVVVLGSQEGAMHTALTGATEIQTSGTTTIFAGHLKCRLKMDKLTLKGMSYVMCTG SFKLEKEVAETQHGTVLVQVKYEGTDAPCKIPFSSQDEKGVTQNGRLITANPIVTDKEKPVNIEAEPPFGESYIVVGAGE KALKLSWFKKGSSIGKMFEATARGARRMAILGDTAWD ; _entity_poly.pdbx_strand_id A,B _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 GLY n 1 2 HIS n 1 3 HIS n 1 4 HIS n 1 5 HIS n 1 6 HIS n 1 7 HIS n 1 8 HIS n 1 9 HIS n 1 10 GLY n 1 11 SER n 1 12 SER n 1 13 THR n 1 14 SER n 1 15 ASN n 1 16 GLY n 1 17 MET n 1 18 ARG n 1 19 CYS n 1 20 VAL n 1 21 GLY n 1 22 ILE n 1 23 GLY n 1 24 ASN n 1 25 ARG n 1 26 ASP n 1 27 PHE n 1 28 VAL n 1 29 GLU n 1 30 GLY n 1 31 LEU n 1 32 SER n 1 33 GLY n 1 34 ALA n 1 35 THR n 1 36 TRP n 1 37 VAL n 1 38 ASP n 1 39 VAL n 1 40 VAL n 1 41 LEU n 1 42 GLU n 1 43 HIS n 1 44 GLY n 1 45 SER n 1 46 CYS n 1 47 VAL n 1 48 THR n 1 49 THR n 1 50 MET n 1 51 ALA n 1 52 LYS n 1 53 ASP n 1 54 LYS n 1 55 PRO n 1 56 THR n 1 57 LEU n 1 58 ASP n 1 59 ILE n 1 60 GLU n 1 61 LEU n 1 62 LEU n 1 63 LYS n 1 64 THR n 1 65 GLU n 1 66 VAL n 1 67 THR n 1 68 ASN n 1 69 PRO n 1 70 ALA n 1 71 VAL n 1 72 LEU n 1 73 ARG n 1 74 LYS n 1 75 LEU n 1 76 CYS n 1 77 ILE n 1 78 GLU n 1 79 ALA n 1 80 LYS n 1 81 ILE n 1 82 SER n 1 83 ASN n 1 84 THR n 1 85 THR n 1 86 THR n 1 87 ASP n 1 88 SER n 1 89 ARG n 1 90 CYS n 1 91 PRO n 1 92 THR n 1 93 GLN n 1 94 GLY n 1 95 GLU n 1 96 ALA n 1 97 THR n 1 98 LEU n 1 99 VAL n 1 100 GLU n 1 101 GLU n 1 102 GLN n 1 103 ASP n 1 104 THR n 1 105 ASN n 1 106 PHE n 1 107 VAL n 1 108 CYS n 1 109 ARG n 1 110 ARG n 1 111 THR n 1 112 PHE n 1 113 VAL n 1 114 ASP n 1 115 ARG n 1 116 GLY n 1 117 HIS n 1 118 GLY n 1 119 ASN n 1 120 GLY n 1 121 CYS n 1 122 GLY n 1 123 LEU n 1 124 PHE n 1 125 GLY n 1 126 LYS n 1 127 GLY n 1 128 SER n 1 129 LEU n 1 130 ILE n 1 131 THR n 1 132 CYS n 1 133 ALA n 1 134 LYS n 1 135 PHE n 1 136 LYS n 1 137 CYS n 1 138 VAL n 1 139 THR n 1 140 LYS n 1 141 LEU n 1 142 GLU n 1 143 GLY n 1 144 LYS n 1 145 ILE n 1 146 VAL n 1 147 GLN n 1 148 TYR n 1 149 GLU n 1 150 ASN n 1 151 LEU n 1 152 LYS n 1 153 TYR n 1 154 SER n 1 155 VAL n 1 156 ILE n 1 157 VAL n 1 158 THR n 1 159 VAL n 1 160 HIS n 1 161 THR n 1 162 GLY n 1 163 ASP n 1 164 GLN n 1 165 HIS n 1 166 GLN n 1 167 VAL n 1 168 GLY n 1 169 ASN n 1 170 GLU n 1 171 THR n 1 172 THR n 1 173 GLU n 1 174 HIS n 1 175 GLY n 1 176 THR n 1 177 ILE n 1 178 ALA n 1 179 THR n 1 180 ILE n 1 181 THR n 1 182 PRO n 1 183 GLN n 1 184 ALA n 1 185 PRO n 1 186 THR n 1 187 SER n 1 188 GLU n 1 189 ILE n 1 190 GLN n 1 191 LEU n 1 192 THR n 1 193 ASP n 1 194 TYR n 1 195 GLY n 1 196 ALA n 1 197 LEU n 1 198 THR n 1 199 LEU n 1 200 ASP n 1 201 CYS n 1 202 SER n 1 203 PRO n 1 204 ARG n 1 205 THR n 1 206 GLY n 1 207 LEU n 1 208 ASP n 1 209 PHE n 1 210 ASN n 1 211 GLU n 1 212 MET n 1 213 VAL n 1 214 LEU n 1 215 LEU n 1 216 THR n 1 217 MET n 1 218 LYS n 1 219 GLU n 1 220 LYS n 1 221 SER n 1 222 TRP n 1 223 LEU n 1 224 VAL n 1 225 HIS n 1 226 LYS n 1 227 GLN n 1 228 TRP n 1 229 PHE n 1 230 LEU n 1 231 ASP n 1 232 LEU n 1 233 PRO n 1 234 LEU n 1 235 PRO n 1 236 TRP n 1 237 THR n 1 238 SER n 1 239 GLY n 1 240 ALA n 1 241 SER n 1 242 THR n 1 243 SER n 1 244 GLN n 1 245 GLU n 1 246 THR n 1 247 TRP n 1 248 ASN n 1 249 ARG n 1 250 GLN n 1 251 ASP n 1 252 LEU n 1 253 LEU n 1 254 VAL n 1 255 THR n 1 256 PHE n 1 257 LYS n 1 258 THR n 1 259 ALA n 1 260 HIS n 1 261 ALA n 1 262 LYS n 1 263 LYS n 1 264 GLN n 1 265 GLU n 1 266 VAL n 1 267 VAL n 1 268 VAL n 1 269 LEU n 1 270 GLY n 1 271 SER n 1 272 GLN n 1 273 GLU n 1 274 GLY n 1 275 ALA n 1 276 MET n 1 277 HIS n 1 278 THR n 1 279 ALA n 1 280 LEU n 1 281 THR n 1 282 GLY n 1 283 ALA n 1 284 THR n 1 285 GLU n 1 286 ILE n 1 287 GLN n 1 288 THR n 1 289 SER n 1 290 GLY n 1 291 THR n 1 292 THR n 1 293 THR n 1 294 ILE n 1 295 PHE n 1 296 ALA n 1 297 GLY n 1 298 HIS n 1 299 LEU n 1 300 LYS n 1 301 CYS n 1 302 ARG n 1 303 LEU n 1 304 LYS n 1 305 MET n 1 306 ASP n 1 307 LYS n 1 308 LEU n 1 309 THR n 1 310 LEU n 1 311 LYS n 1 312 GLY n 1 313 MET n 1 314 SER n 1 315 TYR n 1 316 VAL n 1 317 MET n 1 318 CYS n 1 319 THR n 1 320 GLY n 1 321 SER n 1 322 PHE n 1 323 LYS n 1 324 LEU n 1 325 GLU n 1 326 LYS n 1 327 GLU n 1 328 VAL n 1 329 ALA n 1 330 GLU n 1 331 THR n 1 332 GLN n 1 333 HIS n 1 334 GLY n 1 335 THR n 1 336 VAL n 1 337 LEU n 1 338 VAL n 1 339 GLN n 1 340 VAL n 1 341 LYS n 1 342 TYR n 1 343 GLU n 1 344 GLY n 1 345 THR n 1 346 ASP n 1 347 ALA n 1 348 PRO n 1 349 CYS n 1 350 LYS n 1 351 ILE n 1 352 PRO n 1 353 PHE n 1 354 SER n 1 355 SER n 1 356 GLN n 1 357 ASP n 1 358 GLU n 1 359 LYS n 1 360 GLY n 1 361 VAL n 1 362 THR n 1 363 GLN n 1 364 ASN n 1 365 GLY n 1 366 ARG n 1 367 LEU n 1 368 ILE n 1 369 THR n 1 370 ALA n 1 371 ASN n 1 372 PRO n 1 373 ILE n 1 374 VAL n 1 375 THR n 1 376 ASP n 1 377 LYS n 1 378 GLU n 1 379 LYS n 1 380 PRO n 1 381 VAL n 1 382 ASN n 1 383 ILE n 1 384 GLU n 1 385 ALA n 1 386 GLU n 1 387 PRO n 1 388 PRO n 1 389 PHE n 1 390 GLY n 1 391 GLU n 1 392 SER n 1 393 TYR n 1 394 ILE n 1 395 VAL n 1 396 VAL n 1 397 GLY n 1 398 ALA n 1 399 GLY n 1 400 GLU n 1 401 LYS n 1 402 ALA n 1 403 LEU n 1 404 LYS n 1 405 LEU n 1 406 SER n 1 407 TRP n 1 408 PHE n 1 409 LYS n 1 410 LYS n 1 411 GLY n 1 412 SER n 1 413 SER n 1 414 ILE n 1 415 GLY n 1 416 LYS n 1 417 MET n 1 418 PHE n 1 419 GLU n 1 420 ALA n 1 421 THR n 1 422 ALA n 1 423 ARG n 1 424 GLY n 1 425 ALA n 1 426 ARG n 1 427 ARG n 1 428 MET n 1 429 ALA n 1 430 ILE n 1 431 LEU n 1 432 GLY n 1 433 ASP n 1 434 THR n 1 435 ALA n 1 436 TRP n 1 437 ASP n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name DENV-1 _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene 'Envelope protein' _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain WP74 _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Dengue virus 1' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 11059 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name 'Cabbage looper' _entity_src_gen.pdbx_host_org_scientific_name 'Trichoplusia ni' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 7111 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain Hi5 _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type Baculovirus _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name pFastbac _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code POLG_DEN1W _struct_ref.pdbx_db_accession P17763 _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;MRCVGIGNRDFVEGLSGATWVDVVLEHGSCVTTMAKDKPTLDIELLKTEVTNPAVLRKLCIEAKISNTTTDSRCPTQGEA TLVEEQDTNFVCRRTFVDRGWGNGCGLFGKGSLITCAKFKCVTKLEGKIVQYENLKYSVIVTVHTGDQHQVGNETTEHGT TATITPQAPTSEIQLTDYGALTLDCSPRTGLDFNEMVLLTMEKKSWLVHKQWFLDLPLPWTSGASTSQETWNRQDLLVTF KTAHAKKQEVVVLGSQEGAMHTALTGATEIQTSGTTTIFAGHLKCRLKMDKLTLKGMSYVMCTGSFKLEKEVAETQHGTV LVQVKYEGTDAPCKIPFSSQDEKGVTQNGRLITANPIVTDKEKPVNIEAEPPFGESYIVVGAGEKALKLSWFKKGSSIGK MFEATARGARRMAILGDTAWD ; _struct_ref.pdbx_align_begin 281 _struct_ref.pdbx_db_isoform ? # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 4GT0 A 17 ? 437 ? P17763 281 ? 701 ? 1 421 2 1 4GT0 B 17 ? 437 ? P17763 281 ? 701 ? 1 421 # loop_ _struct_ref_seq_dif.align_id _struct_ref_seq_dif.pdbx_pdb_id_code _struct_ref_seq_dif.mon_id _struct_ref_seq_dif.pdbx_pdb_strand_id _struct_ref_seq_dif.seq_num _struct_ref_seq_dif.pdbx_pdb_ins_code _struct_ref_seq_dif.pdbx_seq_db_name _struct_ref_seq_dif.pdbx_seq_db_accession_code _struct_ref_seq_dif.db_mon_id _struct_ref_seq_dif.pdbx_seq_db_seq_num _struct_ref_seq_dif.details _struct_ref_seq_dif.pdbx_auth_seq_num _struct_ref_seq_dif.pdbx_ordinal 1 4GT0 GLY A 1 ? UNP P17763 ? ? 'EXPRESSION TAG' -15 1 1 4GT0 HIS A 2 ? UNP P17763 ? ? 'EXPRESSION TAG' -14 2 1 4GT0 HIS A 3 ? UNP P17763 ? ? 'EXPRESSION TAG' -13 3 1 4GT0 HIS A 4 ? UNP P17763 ? ? 'EXPRESSION TAG' -12 4 1 4GT0 HIS A 5 ? UNP P17763 ? ? 'EXPRESSION TAG' -11 5 1 4GT0 HIS A 6 ? UNP P17763 ? ? 'EXPRESSION TAG' -10 6 1 4GT0 HIS A 7 ? UNP P17763 ? ? 'EXPRESSION TAG' -9 7 1 4GT0 HIS A 8 ? UNP P17763 ? ? 'EXPRESSION TAG' -8 8 1 4GT0 HIS A 9 ? UNP P17763 ? ? 'EXPRESSION TAG' -7 9 1 4GT0 GLY A 10 ? UNP P17763 ? ? 'EXPRESSION TAG' -6 10 1 4GT0 SER A 11 ? UNP P17763 ? ? 'EXPRESSION TAG' -5 11 1 4GT0 SER A 12 ? UNP P17763 ? ? 'EXPRESSION TAG' -4 12 1 4GT0 THR A 13 ? UNP P17763 ? ? 'EXPRESSION TAG' -3 13 1 4GT0 SER A 14 ? UNP P17763 ? ? 'EXPRESSION TAG' -2 14 1 4GT0 ASN A 15 ? UNP P17763 ? ? 'EXPRESSION TAG' -1 15 1 4GT0 GLY A 16 ? UNP P17763 ? ? 'EXPRESSION TAG' 0 16 1 4GT0 HIS A 117 ? UNP P17763 TRP 381 'ENGINEERED MUTATION' 101 17 1 4GT0 ILE A 177 ? UNP P17763 THR 441 CONFLICT 161 18 1 4GT0 LYS A 218 ? UNP P17763 GLU 482 CONFLICT 202 19 1 4GT0 GLU A 219 ? UNP P17763 LYS 483 CONFLICT 203 20 2 4GT0 GLY B 1 ? UNP P17763 ? ? 'EXPRESSION TAG' -15 21 2 4GT0 HIS B 2 ? UNP P17763 ? ? 'EXPRESSION TAG' -14 22 2 4GT0 HIS B 3 ? UNP P17763 ? ? 'EXPRESSION TAG' -13 23 2 4GT0 HIS B 4 ? UNP P17763 ? ? 'EXPRESSION TAG' -12 24 2 4GT0 HIS B 5 ? UNP P17763 ? ? 'EXPRESSION TAG' -11 25 2 4GT0 HIS B 6 ? UNP P17763 ? ? 'EXPRESSION TAG' -10 26 2 4GT0 HIS B 7 ? UNP P17763 ? ? 'EXPRESSION TAG' -9 27 2 4GT0 HIS B 8 ? UNP P17763 ? ? 'EXPRESSION TAG' -8 28 2 4GT0 HIS B 9 ? UNP P17763 ? ? 'EXPRESSION TAG' -7 29 2 4GT0 GLY B 10 ? UNP P17763 ? ? 'EXPRESSION TAG' -6 30 2 4GT0 SER B 11 ? UNP P17763 ? ? 'EXPRESSION TAG' -5 31 2 4GT0 SER B 12 ? UNP P17763 ? ? 'EXPRESSION TAG' -4 32 2 4GT0 THR B 13 ? UNP P17763 ? ? 'EXPRESSION TAG' -3 33 2 4GT0 SER B 14 ? UNP P17763 ? ? 'EXPRESSION TAG' -2 34 2 4GT0 ASN B 15 ? UNP P17763 ? ? 'EXPRESSION TAG' -1 35 2 4GT0 GLY B 16 ? UNP P17763 ? ? 'EXPRESSION TAG' 0 36 2 4GT0 HIS B 117 ? UNP P17763 TRP 381 'ENGINEERED MUTATION' 101 37 2 4GT0 ILE B 177 ? UNP P17763 THR 441 CONFLICT 161 38 2 4GT0 LYS B 218 ? UNP P17763 GLU 482 CONFLICT 202 39 2 4GT0 GLU B 219 ? UNP P17763 LYS 483 CONFLICT 203 40 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CD non-polymer . 'CADMIUM ION' ? 'Cd 2' 112.411 CL non-polymer . 'CHLORIDE ION' ? 'Cl -1' 35.453 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 4GT0 _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 2.67 _exptl_crystal.density_percent_sol 53.99 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.temp 293 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 4.5 _exptl_crystal_grow.pdbx_details 'pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K' _exptl_crystal_grow.pdbx_pH_range ? # _diffrn.id 1 _diffrn.ambient_temp 200 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type 'ADSC QUANTUM 315' _diffrn_detector.pdbx_collection_date 2011-11-13 _diffrn_detector.details mirrors # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator 'Double crystal, Si(111)' _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.999 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'ALS BEAMLINE 8.2.2' _diffrn_source.pdbx_synchrotron_site ALS _diffrn_source.pdbx_synchrotron_beamline 8.2.2 _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list 0.999 # _reflns.entry_id 4GT0 _reflns.observed_criterion_sigma_I -3 _reflns.observed_criterion_sigma_F -3 _reflns.d_resolution_low 50 _reflns.d_resolution_high 2.57 _reflns.number_obs 31819 _reflns.number_all 31819 _reflns.percent_possible_obs 99.6 _reflns.pdbx_Rmerge_I_obs 0.116 _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI ? _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy ? _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # _reflns_shell.d_res_high 2.57 _reflns_shell.d_res_low 2.65 _reflns_shell.percent_possible_all 99.1 _reflns_shell.Rmerge_I_obs .521 _reflns_shell.pdbx_Rsym_value ? _reflns_shell.meanI_over_sigI_obs 1.92 _reflns_shell.pdbx_redundancy 7.3 _reflns_shell.percent_possible_obs ? _reflns_shell.number_unique_all 3046 _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_unique_obs ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 # _refine.entry_id 4GT0 _refine.ls_number_reflns_obs 31744 _refine.ls_number_reflns_all 31744 _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F 1.40 _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 28.481 _refine.ls_d_res_high 2.57 _refine.ls_percent_reflns_obs 99.64 _refine.ls_R_factor_obs 0.1830 _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work 0.1769 _refine.ls_R_factor_R_free 0.2099 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 4.92 _refine.ls_number_reflns_R_free 1562 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc ? _refine.correlation_coeff_Fo_to_Fc_free ? _refine.B_iso_mean ? _refine.aniso_B[1][1] ? _refine.aniso_B[2][2] ? _refine.aniso_B[3][3] ? _refine.aniso_B[1][2] ? _refine.aniso_B[1][3] ? _refine.aniso_B[2][3] ? _refine.solvent_model_details 'FLAT BULK SOLVENT MODEL' _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.11 _refine.pdbx_solvent_ion_probe_radii ? _refine.pdbx_solvent_shrinkage_radii 0.90 _refine.pdbx_ls_cross_valid_method ? _refine.details ? _refine.pdbx_starting_model ? _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values TWIN_LSQ_F _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R ? _refine.pdbx_overall_ESU_R_Free ? _refine.overall_SU_ML . _refine.pdbx_overall_phase_error 20.54 _refine.overall_SU_B ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_diffrn_id 1 _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 5944 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 33 _refine_hist.number_atoms_solvent 223 _refine_hist.number_atoms_total 6200 _refine_hist.d_res_high 2.57 _refine_hist.d_res_low 28.481 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_restraint_function _refine_ls_restr.pdbx_refine_id f_bond_d 0.003 ? ? 6132 ? 'X-RAY DIFFRACTION' f_angle_d 0.642 ? ? 8299 ? 'X-RAY DIFFRACTION' f_dihedral_angle_d 15.249 ? ? 2242 ? 'X-RAY DIFFRACTION' f_chiral_restr 0.040 ? ? 990 ? 'X-RAY DIFFRACTION' f_plane_restr 0.002 ? ? 1038 ? 'X-RAY DIFFRACTION' # loop_ _refine_ls_shell.pdbx_total_number_of_bins_used _refine_ls_shell.d_res_high _refine_ls_shell.d_res_low _refine_ls_shell.number_reflns_R_work _refine_ls_shell.R_factor_R_work _refine_ls_shell.percent_reflns_obs _refine_ls_shell.R_factor_R_free _refine_ls_shell.R_factor_R_free_error _refine_ls_shell.percent_reflns_R_free _refine_ls_shell.number_reflns_R_free _refine_ls_shell.number_reflns_all _refine_ls_shell.R_factor_all _refine_ls_shell.number_reflns_obs _refine_ls_shell.redundancy_reflns_obs _refine_ls_shell.pdbx_refine_id . 2.5717 2.6546 2707 0.2526 94.00 0.3445 . . 135 . . . . 'X-RAY DIFFRACTION' . 2.6546 2.7493 2745 0.2136 95.00 0.2495 . . 142 . . . . 'X-RAY DIFFRACTION' . 2.7493 2.8591 2731 0.2001 95.00 0.2369 . . 142 . . . . 'X-RAY DIFFRACTION' . 2.8591 2.9889 2759 0.1837 95.00 0.2328 . . 143 . . . . 'X-RAY DIFFRACTION' . 2.9889 3.1460 2714 0.1747 95.00 0.2107 . . 141 . . . . 'X-RAY DIFFRACTION' . 3.1460 3.3424 2718 0.1746 95.00 0.2522 . . 147 . . . . 'X-RAY DIFFRACTION' . 3.3424 3.5993 2734 0.1814 95.00 0.2017 . . 138 . . . . 'X-RAY DIFFRACTION' . 3.5993 3.9595 2751 0.1728 95.00 0.1905 . . 143 . . . . 'X-RAY DIFFRACTION' . 3.9595 4.5277 2757 0.1606 95.00 0.2148 . . 138 . . . . 'X-RAY DIFFRACTION' . 4.5277 5.6864 2726 0.1483 95.00 0.1795 . . 148 . . . . 'X-RAY DIFFRACTION' . 5.6864 21.3310 2773 0.2090 95.00 0.2217 . . 144 . . . . 'X-RAY DIFFRACTION' # _struct.entry_id 4GT0 _struct.title 'Structure of dengue virus serotype 1 sE containing stem to residue 421' _struct.pdbx_descriptor 'Envelope protein E' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 4GT0 _struct_keywords.pdbx_keywords 'VIRAL PROTEIN' _struct_keywords.text 'Viral fusion protein, VIRAL PROTEIN' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 1 ? C N N 2 ? D N N 3 ? E N N 3 ? F N N 4 ? G N N 2 ? H N N 3 ? I N N 3 ? J N N 5 ? K N N 5 ? # _struct_biol.id 1 _struct_biol.details ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 GLY A 23 ? ARG A 25 ? GLY A 7 ARG A 9 5 ? 3 HELX_P HELX_P2 2 LEU A 98 ? ASP A 103 ? LEU A 82 ASP A 87 5 ? 6 HELX_P HELX_P3 3 GLY A 116 ? GLY A 120 ? GLY A 100 GLY A 104 5 ? 5 HELX_P HELX_P4 4 GLN A 147 ? GLU A 149 ? GLN A 131 GLU A 133 5 ? 3 HELX_P HELX_P5 5 LYS A 226 ? ASP A 231 ? LYS A 210 ASP A 215 1 ? 6 HELX_P HELX_P6 6 ARG A 249 ? LEU A 252 ? ARG A 233 LEU A 236 5 ? 4 HELX_P HELX_P7 7 GLN A 272 ? LEU A 280 ? GLN A 256 LEU A 264 1 ? 9 HELX_P HELX_P8 8 ALA A 398 ? ALA A 402 ? ALA A 382 ALA A 386 5 ? 5 HELX_P HELX_P9 9 GLY B 23 ? ARG B 25 ? GLY B 7 ARG B 9 5 ? 3 HELX_P HELX_P10 10 LEU B 98 ? GLN B 102 ? LEU B 82 GLN B 86 5 ? 5 HELX_P HELX_P11 11 GLN B 147 ? GLU B 149 ? GLN B 131 GLU B 133 5 ? 3 HELX_P HELX_P12 12 LYS B 226 ? ASP B 231 ? LYS B 210 ASP B 215 1 ? 6 HELX_P HELX_P13 13 ARG B 249 ? LEU B 252 ? ARG B 233 LEU B 236 5 ? 4 HELX_P HELX_P14 14 GLN B 272 ? LEU B 280 ? GLN B 256 LEU B 264 1 ? 9 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 19 SG ? ? ? 1_555 A CYS 46 SG ? ? A CYS 3 A CYS 30 1_555 ? ? ? ? ? ? ? 2.030 ? disulf2 disulf ? ? A CYS 76 SG ? ? ? 1_555 A CYS 137 SG ? ? A CYS 60 A CYS 121 1_555 ? ? ? ? ? ? ? 2.030 ? disulf3 disulf ? ? A CYS 90 SG ? ? ? 1_555 A CYS 121 SG ? ? A CYS 74 A CYS 105 1_555 ? ? ? ? ? ? ? 2.029 ? disulf4 disulf ? ? A CYS 108 SG ? ? ? 1_555 A CYS 132 SG ? ? A CYS 92 A CYS 116 1_555 ? ? ? ? ? ? ? 2.031 ? disulf5 disulf ? ? A CYS 201 SG ? ? ? 1_555 A CYS 301 SG ? ? A CYS 185 A CYS 285 1_555 ? ? ? ? ? ? ? 2.031 ? disulf6 disulf ? ? A CYS 318 SG ? ? ? 1_555 A CYS 349 SG ? ? A CYS 302 A CYS 333 1_555 ? ? ? ? ? ? ? 2.030 ? disulf7 disulf ? ? B CYS 19 SG ? ? ? 1_555 B CYS 46 SG ? ? B CYS 3 B CYS 30 1_555 ? ? ? ? ? ? ? 2.031 ? disulf8 disulf ? ? B CYS 76 SG ? ? ? 1_555 B CYS 137 SG ? ? B CYS 60 B CYS 121 1_555 ? ? ? ? ? ? ? 2.032 ? disulf9 disulf ? ? B CYS 90 SG ? ? ? 1_555 B CYS 121 SG ? ? B CYS 74 B CYS 105 1_555 ? ? ? ? ? ? ? 2.030 ? disulf10 disulf ? ? B CYS 108 SG ? ? ? 1_555 B CYS 132 SG ? ? B CYS 92 B CYS 116 1_555 ? ? ? ? ? ? ? 2.031 ? disulf11 disulf ? ? B CYS 201 SG ? ? ? 1_555 B CYS 301 SG ? ? B CYS 185 B CYS 285 1_555 ? ? ? ? ? ? ? 2.031 ? disulf12 disulf ? ? B CYS 318 SG ? ? ? 1_555 B CYS 349 SG ? ? B CYS 302 B CYS 333 1_555 ? ? ? ? ? ? ? 2.030 ? metalc1 metalc ? ? B ASP 26 OD1 ? ? ? 1_555 H CD . CD ? ? B ASP 10 B CD 502 1_555 ? ? ? ? ? ? ? 2.466 ? metalc2 metalc ? ? B GLU 327 OE2 ? ? ? 1_555 D CD . CD ? ? B GLU 311 A CD 502 1_555 ? ? ? ? ? ? ? 2.485 ? metalc3 metalc ? ? B GLU 327 OE1 ? ? ? 1_555 D CD . CD ? ? B GLU 311 A CD 502 1_555 ? ? ? ? ? ? ? 2.486 ? metalc4 metalc ? ? A ASP 114 OD2 ? ? ? 1_555 D CD . CD ? ? A ASP 98 A CD 502 1_555 ? ? ? ? ? ? ? 2.492 ? metalc5 metalc ? ? B HIS 43 NE2 ? ? ? 1_555 I CD . CD ? ? B HIS 27 B CD 503 1_555 ? ? ? ? ? ? ? 2.505 ? metalc6 metalc ? ? A ASP 26 OD1 ? ? ? 1_555 E CD . CD ? ? A ASP 10 A CD 503 1_555 ? ? ? ? ? ? ? 2.505 ? metalc7 metalc ? ? B HIS 298 NE2 ? ? ? 1_555 I CD . CD ? ? B HIS 282 B CD 503 1_555 ? ? ? ? ? ? ? 2.511 ? metalc8 metalc ? ? A ASP 26 OD2 ? ? ? 1_555 E CD . CD ? ? A ASP 10 A CD 503 1_555 ? ? ? ? ? ? ? 2.513 ? metalc9 metalc ? ? B ASP 26 OD2 ? ? ? 1_555 H CD . CD ? ? B ASP 10 B CD 502 1_555 ? ? ? ? ? ? ? 2.535 ? metalc10 metalc ? ? E CD . CD ? ? ? 1_555 J HOH . O ? ? A CD 503 A HOH 637 1_555 ? ? ? ? ? ? ? 2.560 ? metalc11 metalc ? ? H CD . CD ? ? ? 1_555 K HOH . O ? ? B CD 502 B HOH 641 1_555 ? ? ? ? ? ? ? 2.560 ? metalc12 metalc ? ? E CD . CD ? ? ? 1_555 J HOH . O ? ? A CD 503 A HOH 713 1_555 ? ? ? ? ? ? ? 2.592 ? metalc13 metalc ? ? E CD . CD ? ? ? 1_555 J HOH . O ? ? A CD 503 A HOH 620 1_555 ? ? ? ? ? ? ? 2.592 ? covale1 covale ? ? A ASN 83 ND2 ? ? ? 1_555 C NAG . C1 ? ? A ASN 67 A NAG 501 1_555 ? ? ? ? ? ? ? 1.837 ? covale2 covale ? ? B ASN 83 ND2 ? ? ? 1_555 G NAG . C1 ? ? B ASN 67 B NAG 501 1_555 ? ? ? ? ? ? ? 1.760 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? metalc ? ? covale ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 ALA 347 A . ? ALA 331 A PRO 348 A ? PRO 332 A 1 2.07 2 ALA 347 B . ? ALA 331 B PRO 348 B ? PRO 332 B 1 1.75 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 5 ? B ? 5 ? C ? 5 ? D ? 4 ? E ? 5 ? F ? 2 ? G ? 3 ? H ? 3 ? I ? 2 ? J ? 3 ? K ? 5 ? L ? 5 ? M ? 5 ? N ? 4 ? O ? 5 ? P ? 2 ? Q ? 3 ? R ? 3 ? S ? 2 ? T ? 3 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? parallel A 2 3 ? anti-parallel A 3 4 ? anti-parallel A 4 5 ? anti-parallel B 1 2 ? parallel B 2 3 ? anti-parallel B 3 4 ? anti-parallel B 4 5 ? anti-parallel C 1 2 ? anti-parallel C 2 3 ? anti-parallel C 3 4 ? anti-parallel C 4 5 ? anti-parallel D 1 2 ? anti-parallel D 2 3 ? anti-parallel D 3 4 ? anti-parallel E 1 2 ? anti-parallel E 2 3 ? anti-parallel E 3 4 ? anti-parallel E 4 5 ? anti-parallel F 1 2 ? anti-parallel G 1 2 ? anti-parallel G 2 3 ? anti-parallel H 1 2 ? anti-parallel H 2 3 ? anti-parallel I 1 2 ? anti-parallel J 1 2 ? anti-parallel J 2 3 ? anti-parallel K 1 2 ? parallel K 2 3 ? anti-parallel K 3 4 ? anti-parallel K 4 5 ? anti-parallel L 1 2 ? parallel L 2 3 ? anti-parallel L 3 4 ? anti-parallel L 4 5 ? anti-parallel M 1 2 ? anti-parallel M 2 3 ? anti-parallel M 3 4 ? anti-parallel M 4 5 ? anti-parallel N 1 2 ? anti-parallel N 2 3 ? anti-parallel N 3 4 ? anti-parallel O 1 2 ? anti-parallel O 2 3 ? anti-parallel O 3 4 ? anti-parallel O 4 5 ? anti-parallel P 1 2 ? anti-parallel Q 1 2 ? anti-parallel Q 2 3 ? anti-parallel R 1 2 ? anti-parallel R 2 3 ? anti-parallel S 1 2 ? anti-parallel T 1 2 ? anti-parallel T 2 3 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 VAL A 20 ? GLY A 21 ? VAL A 4 GLY A 5 A 2 VAL A 47 ? THR A 49 ? VAL A 31 THR A 33 A 3 LEU A 57 ? THR A 67 ? LEU A 41 THR A 51 A 4 LEU A 151 ? VAL A 159 ? LEU A 135 VAL A 143 A 5 THR A 176 ? ILE A 180 ? THR A 160 ILE A 164 B 1 VAL A 20 ? GLY A 21 ? VAL A 4 GLY A 5 B 2 VAL A 47 ? THR A 49 ? VAL A 31 THR A 33 B 3 LEU A 57 ? THR A 67 ? LEU A 41 THR A 51 B 4 THR A 292 ? PHE A 295 ? THR A 276 PHE A 279 B 5 THR A 288 ? SER A 289 ? THR A 272 SER A 273 C 1 PHE A 27 ? GLU A 29 ? PHE A 11 GLU A 13 C 2 ALA A 34 ? GLU A 42 ? ALA A 18 GLU A 26 C 3 HIS A 298 ? ASP A 306 ? HIS A 282 ASP A 290 C 4 GLY A 195 ? PRO A 203 ? GLY A 179 PRO A 187 C 5 THR A 186 ? LEU A 191 ? THR A 170 LEU A 175 D 1 PHE A 106 ? ARG A 115 ? PHE A 90 ARG A 99 D 2 GLY A 125 ? ILE A 145 ? GLY A 109 ILE A 129 D 3 ALA A 70 ? SER A 88 ? ALA A 54 SER A 72 D 4 TRP A 236 ? SER A 238 ? TRP A 220 SER A 222 E 1 PHE A 106 ? ARG A 115 ? PHE A 90 ARG A 99 E 2 GLY A 125 ? ILE A 145 ? GLY A 109 ILE A 129 E 3 MET A 212 ? MET A 217 ? MET A 196 MET A 201 E 4 LYS A 220 ? HIS A 225 ? LYS A 204 HIS A 209 E 5 THR A 284 ? ILE A 286 ? THR A 268 ILE A 270 F 1 VAL A 254 ? ALA A 259 ? VAL A 238 ALA A 243 F 2 GLN A 264 ? VAL A 268 ? GLN A 248 VAL A 252 G 1 PHE A 322 ? LEU A 324 ? PHE A 306 LEU A 308 G 2 VAL A 336 ? TYR A 342 ? VAL A 320 TYR A 326 G 3 ALA A 329 ? GLU A 330 ? ALA A 313 GLU A 314 H 1 PHE A 322 ? LEU A 324 ? PHE A 306 LEU A 308 H 2 VAL A 336 ? TYR A 342 ? VAL A 320 TYR A 326 H 3 VAL A 381 ? ALA A 385 ? VAL A 365 ALA A 369 I 1 CYS A 349 ? LYS A 350 ? CYS A 333 LYS A 334 I 2 ILE A 373 ? VAL A 374 ? ILE A 357 VAL A 358 J 1 PHE A 353 ? ASP A 357 ? PHE A 337 ASP A 341 J 2 GLY A 390 ? VAL A 396 ? GLY A 374 VAL A 380 J 3 LEU A 403 ? LYS A 409 ? LEU A 387 LYS A 393 K 1 VAL B 20 ? GLY B 21 ? VAL B 4 GLY B 5 K 2 CYS B 46 ? MET B 50 ? CYS B 30 MET B 34 K 3 THR B 56 ? THR B 67 ? THR B 40 THR B 51 K 4 LEU B 151 ? VAL B 159 ? LEU B 135 VAL B 143 K 5 THR B 176 ? ILE B 180 ? THR B 160 ILE B 164 L 1 VAL B 20 ? GLY B 21 ? VAL B 4 GLY B 5 L 2 CYS B 46 ? MET B 50 ? CYS B 30 MET B 34 L 3 THR B 56 ? THR B 67 ? THR B 40 THR B 51 L 4 THR B 292 ? PHE B 295 ? THR B 276 PHE B 279 L 5 THR B 288 ? SER B 289 ? THR B 272 SER B 273 M 1 PHE B 27 ? GLU B 29 ? PHE B 11 GLU B 13 M 2 ALA B 34 ? GLU B 42 ? ALA B 18 GLU B 26 M 3 HIS B 298 ? ASP B 306 ? HIS B 282 ASP B 290 M 4 GLY B 195 ? PRO B 203 ? GLY B 179 PRO B 187 M 5 THR B 186 ? LEU B 191 ? THR B 170 LEU B 175 N 1 PHE B 106 ? ASP B 114 ? PHE B 90 ASP B 98 N 2 LYS B 126 ? ILE B 145 ? LYS B 110 ILE B 129 N 3 ALA B 70 ? SER B 88 ? ALA B 54 SER B 72 N 4 TRP B 236 ? SER B 238 ? TRP B 220 SER B 222 O 1 PHE B 106 ? ASP B 114 ? PHE B 90 ASP B 98 O 2 LYS B 126 ? ILE B 145 ? LYS B 110 ILE B 129 O 3 MET B 212 ? MET B 217 ? MET B 196 MET B 201 O 4 LYS B 220 ? HIS B 225 ? LYS B 204 HIS B 209 O 5 GLU B 285 ? ILE B 286 ? GLU B 269 ILE B 270 P 1 VAL B 254 ? HIS B 260 ? VAL B 238 HIS B 244 P 2 LYS B 263 ? VAL B 268 ? LYS B 247 VAL B 252 Q 1 PHE B 322 ? LEU B 324 ? PHE B 306 LEU B 308 Q 2 VAL B 336 ? TYR B 342 ? VAL B 320 TYR B 326 Q 3 ALA B 329 ? GLU B 330 ? ALA B 313 GLU B 314 R 1 PHE B 322 ? LEU B 324 ? PHE B 306 LEU B 308 R 2 VAL B 336 ? TYR B 342 ? VAL B 320 TYR B 326 R 3 VAL B 381 ? ALA B 385 ? VAL B 365 ALA B 369 S 1 CYS B 349 ? LYS B 350 ? CYS B 333 LYS B 334 S 2 ILE B 373 ? VAL B 374 ? ILE B 357 VAL B 358 T 1 PHE B 353 ? GLN B 356 ? PHE B 337 GLN B 340 T 2 GLY B 390 ? VAL B 396 ? GLY B 374 VAL B 380 T 3 LEU B 403 ? LYS B 409 ? LEU B 387 LYS B 393 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 N VAL A 20 ? N VAL A 4 O THR A 48 ? O THR A 32 A 2 3 N VAL A 47 ? N VAL A 31 O ILE A 59 ? O ILE A 43 A 3 4 N LEU A 62 ? N LEU A 46 O SER A 154 ? O SER A 138 A 4 5 N VAL A 155 ? N VAL A 139 O ALA A 178 ? O ALA A 162 B 1 2 N VAL A 20 ? N VAL A 4 O THR A 48 ? O THR A 32 B 2 3 N VAL A 47 ? N VAL A 31 O ILE A 59 ? O ILE A 43 B 3 4 N VAL A 66 ? N VAL A 50 O THR A 293 ? O THR A 277 B 4 5 O THR A 292 ? O THR A 276 N SER A 289 ? N SER A 273 C 1 2 N VAL A 28 ? N VAL A 12 O TRP A 36 ? O TRP A 20 C 2 3 N VAL A 39 ? N VAL A 23 O CYS A 301 ? O CYS A 285 C 3 4 O LYS A 300 ? O LYS A 284 N SER A 202 ? N SER A 186 C 4 5 O LEU A 199 ? O LEU A 183 N SER A 187 ? N SER A 171 D 1 2 N VAL A 113 ? N VAL A 97 O GLY A 127 ? O GLY A 111 D 2 3 O GLY A 143 ? O GLY A 127 N LEU A 72 ? N LEU A 56 D 3 4 N LYS A 74 ? N LYS A 58 O THR A 237 ? O THR A 221 E 1 2 N VAL A 113 ? N VAL A 97 O GLY A 127 ? O GLY A 111 E 2 3 N LYS A 144 ? N LYS A 128 O LEU A 214 ? O LEU A 198 E 3 4 N VAL A 213 ? N VAL A 197 O VAL A 224 ? O VAL A 208 E 4 5 N SER A 221 ? N SER A 205 O ILE A 286 ? O ILE A 270 F 1 2 N THR A 255 ? N THR A 239 O VAL A 267 ? O VAL A 251 G 1 2 N LYS A 323 ? N LYS A 307 O LYS A 341 ? O LYS A 325 G 2 3 O LEU A 337 ? O LEU A 321 N ALA A 329 ? N ALA A 313 H 1 2 N LYS A 323 ? N LYS A 307 O LYS A 341 ? O LYS A 325 H 2 3 N VAL A 338 ? N VAL A 322 O ILE A 383 ? O ILE A 367 I 1 2 N CYS A 349 ? N CYS A 333 O VAL A 374 ? O VAL A 358 J 1 2 N SER A 354 ? N SER A 338 O VAL A 395 ? O VAL A 379 J 2 3 N GLY A 390 ? N GLY A 374 O LYS A 409 ? O LYS A 393 K 1 2 N VAL B 20 ? N VAL B 4 O CYS B 46 ? O CYS B 30 K 2 3 N THR B 49 ? N THR B 33 O LEU B 57 ? O LEU B 41 K 3 4 N LEU B 62 ? N LEU B 46 O SER B 154 ? O SER B 138 K 4 5 N VAL B 155 ? N VAL B 139 O ALA B 178 ? O ALA B 162 L 1 2 N VAL B 20 ? N VAL B 4 O CYS B 46 ? O CYS B 30 L 2 3 N THR B 49 ? N THR B 33 O LEU B 57 ? O LEU B 41 L 3 4 N VAL B 66 ? N VAL B 50 O THR B 293 ? O THR B 277 L 4 5 O THR B 292 ? O THR B 276 N SER B 289 ? N SER B 273 M 1 2 N VAL B 28 ? N VAL B 12 O TRP B 36 ? O TRP B 20 M 2 3 N VAL B 39 ? N VAL B 23 O CYS B 301 ? O CYS B 285 M 3 4 O LYS B 300 ? O LYS B 284 N SER B 202 ? N SER B 186 M 4 5 O GLY B 195 ? O GLY B 179 N LEU B 191 ? N LEU B 175 N 1 2 N VAL B 113 ? N VAL B 97 O GLY B 127 ? O GLY B 111 N 2 3 O GLY B 143 ? O GLY B 127 N LEU B 72 ? N LEU B 56 N 3 4 N LYS B 74 ? N LYS B 58 O THR B 237 ? O THR B 221 O 1 2 N VAL B 113 ? N VAL B 97 O GLY B 127 ? O GLY B 111 O 2 3 N LYS B 144 ? N LYS B 128 O LEU B 214 ? O LEU B 198 O 3 4 N VAL B 213 ? N VAL B 197 O VAL B 224 ? O VAL B 208 O 4 5 N SER B 221 ? N SER B 205 O ILE B 286 ? O ILE B 270 P 1 2 N HIS B 260 ? N HIS B 244 O LYS B 263 ? O LYS B 247 Q 1 2 N LYS B 323 ? N LYS B 307 O LYS B 341 ? O LYS B 325 Q 2 3 O LEU B 337 ? O LEU B 321 N ALA B 329 ? N ALA B 313 R 1 2 N LYS B 323 ? N LYS B 307 O LYS B 341 ? O LYS B 325 R 2 3 N VAL B 338 ? N VAL B 322 O ILE B 383 ? O ILE B 367 S 1 2 N CYS B 349 ? N CYS B 333 O VAL B 374 ? O VAL B 358 T 1 2 N GLN B 356 ? N GLN B 340 O TYR B 393 ? O TYR B 377 T 2 3 N ILE B 394 ? N ILE B 378 O LEU B 405 ? O LEU B 389 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE NAG A 501' AC2 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE CD A 502' AC3 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE CD A 503' AC4 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE CL A 504' AC5 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE NAG B 501' AC6 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE CD B 502' AC7 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE CD B 503' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 4 ASN A 83 ? ASN A 67 . ? 1_555 ? 2 AC1 4 HOH J . ? HOH A 611 . ? 1_555 ? 3 AC1 4 HOH J . ? HOH A 615 . ? 1_555 ? 4 AC1 4 HOH J . ? HOH A 667 . ? 1_555 ? 5 AC2 4 THR A 92 ? THR A 76 . ? 3_455 ? 6 AC2 4 GLY A 94 ? GLY A 78 . ? 3_455 ? 7 AC2 4 ASP A 114 ? ASP A 98 . ? 1_555 ? 8 AC2 4 GLU B 327 ? GLU B 311 . ? 1_555 ? 9 AC3 4 ASP A 26 ? ASP A 10 . ? 1_555 ? 10 AC3 4 HOH J . ? HOH A 620 . ? 1_555 ? 11 AC3 4 HOH J . ? HOH A 637 . ? 1_555 ? 12 AC3 4 HOH J . ? HOH A 713 . ? 1_555 ? 13 AC4 4 GLY A 118 ? GLY A 102 . ? 1_555 ? 14 AC4 4 PHE A 124 ? PHE A 108 . ? 1_555 ? 15 AC4 4 HOH J . ? HOH A 608 . ? 1_555 ? 16 AC4 4 GLU B 327 ? GLU B 311 . ? 1_555 ? 17 AC5 2 ASN B 83 ? ASN B 67 . ? 1_555 ? 18 AC5 2 LYS B 134 ? LYS B 118 . ? 1_555 ? 19 AC6 2 ASP B 26 ? ASP B 10 . ? 1_555 ? 20 AC6 2 HOH K . ? HOH B 641 . ? 1_555 ? 21 AC7 3 HIS B 43 ? HIS B 27 . ? 1_555 ? 22 AC7 3 HIS B 298 ? HIS B 282 . ? 1_555 ? 23 AC7 3 GLU B 384 ? GLU B 368 . ? 1_555 ? # _database_PDB_matrix.entry_id 4GT0 _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 4GT0 _atom_sites.fract_transf_matrix[1][1] 0.012838 _atom_sites.fract_transf_matrix[1][2] 0.007412 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.014824 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.003421 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C CD CL N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . ARG A 1 18 ? -27.177 -2.530 -56.499 1.00 27.69 ? 2 ARG A N 1 ATOM 2 C CA . ARG A 1 18 ? -27.469 -2.392 -55.077 1.00 21.97 ? 2 ARG A CA 1 ATOM 3 C C . ARG A 1 18 ? -28.186 -1.075 -54.789 1.00 20.51 ? 2 ARG A C 1 ATOM 4 O O . ARG A 1 18 ? -28.833 -0.928 -53.752 1.00 27.32 ? 2 ARG A O 1 ATOM 5 C CB . ARG A 1 18 ? -26.178 -2.470 -54.259 1.00 20.95 ? 2 ARG A CB 1 ATOM 6 C CG . ARG A 1 18 ? -26.406 -2.513 -52.758 1.00 29.29 ? 2 ARG A CG 1 ATOM 7 C CD . ARG A 1 18 ? -25.096 -2.584 -51.991 1.00 31.45 ? 2 ARG A CD 1 ATOM 8 N NE . ARG A 1 18 ? -24.545 -1.259 -51.719 1.00 34.82 ? 2 ARG A NE 1 ATOM 9 C CZ . ARG A 1 18 ? -25.050 -0.407 -50.832 1.00 28.14 ? 2 ARG A CZ 1 ATOM 10 N NH1 . ARG A 1 18 ? -26.130 -0.730 -50.132 1.00 22.07 ? 2 ARG A NH1 1 ATOM 11 N NH2 . ARG A 1 18 ? -24.484 0.776 -50.647 1.00 31.23 ? 2 ARG A NH2 1 ATOM 12 N N . CYS A 1 19 ? -28.068 -0.122 -55.709 1.00 23.31 ? 3 CYS A N 1 ATOM 13 C CA . CYS A 1 19 ? -28.688 1.186 -55.539 1.00 12.56 ? 3 CYS A CA 1 ATOM 14 C C . CYS A 1 19 ? -30.055 1.231 -56.209 1.00 12.71 ? 3 CYS A C 1 ATOM 15 O O . CYS A 1 19 ? -30.275 0.589 -57.236 1.00 9.96 ? 3 CYS A O 1 ATOM 16 C CB . CYS A 1 19 ? -27.793 2.276 -56.132 1.00 12.97 ? 3 CYS A CB 1 ATOM 17 S SG . CYS A 1 19 ? -26.106 2.292 -55.490 1.00 14.43 ? 3 CYS A SG 1 ATOM 18 N N . VAL A 1 20 ? -30.970 1.995 -55.621 1.00 13.68 ? 4 VAL A N 1 ATOM 19 C CA . VAL A 1 20 ? -32.290 2.181 -56.202 1.00 9.24 ? 4 VAL A CA 1 ATOM 20 C C . VAL A 1 20 ? -32.252 3.315 -57.217 1.00 10.65 ? 4 VAL A C 1 ATOM 21 O O . VAL A 1 20 ? -31.743 4.399 -56.932 1.00 14.79 ? 4 VAL A O 1 ATOM 22 C CB . VAL A 1 20 ? -33.336 2.520 -55.134 1.00 9.15 ? 4 VAL A CB 1 ATOM 23 C CG1 . VAL A 1 20 ? -34.695 2.742 -55.784 1.00 10.04 ? 4 VAL A CG1 1 ATOM 24 C CG2 . VAL A 1 20 ? -33.411 1.414 -54.103 1.00 13.56 ? 4 VAL A CG2 1 ATOM 25 N N . GLY A 1 21 ? -32.795 3.061 -58.402 1.00 9.08 ? 5 GLY A N 1 ATOM 26 C CA . GLY A 1 21 ? -32.817 4.056 -59.456 1.00 7.07 ? 5 GLY A CA 1 ATOM 27 C C . GLY A 1 21 ? -33.836 5.146 -59.188 1.00 9.02 ? 5 GLY A C 1 ATOM 28 O O . GLY A 1 21 ? -34.887 4.896 -58.600 1.00 11.98 ? 5 GLY A O 1 ATOM 29 N N . ILE A 1 22 ? -33.522 6.361 -59.625 1.00 10.03 ? 6 ILE A N 1 ATOM 30 C CA . ILE A 1 22 ? -34.406 7.502 -59.420 1.00 12.49 ? 6 ILE A CA 1 ATOM 31 C C . ILE A 1 22 ? -35.483 7.563 -60.498 1.00 11.69 ? 6 ILE A C 1 ATOM 32 O O . ILE A 1 22 ? -35.178 7.651 -61.687 1.00 13.19 ? 6 ILE A O 1 ATOM 33 C CB . ILE A 1 22 ? -33.612 8.824 -59.420 1.00 16.03 ? 6 ILE A CB 1 ATOM 34 C CG1 . ILE A 1 22 ? -32.663 8.863 -58.219 1.00 13.09 ? 6 ILE A CG1 1 ATOM 35 C CG2 . ILE A 1 22 ? -34.558 10.019 -59.392 1.00 7.71 ? 6 ILE A CG2 1 ATOM 36 C CD1 . ILE A 1 22 ? -31.793 10.098 -58.158 1.00 16.13 ? 6 ILE A CD1 1 ATOM 37 N N . GLY A 1 23 ? -36.743 7.514 -60.077 1.00 10.12 ? 7 GLY A N 1 ATOM 38 C CA . GLY A 1 23 ? -37.858 7.597 -61.001 1.00 6.70 ? 7 GLY A CA 1 ATOM 39 C C . GLY A 1 23 ? -37.940 8.972 -61.633 1.00 5.90 ? 7 GLY A C 1 ATOM 40 O O . GLY A 1 23 ? -37.367 9.931 -61.119 1.00 11.70 ? 7 GLY A O 1 ATOM 41 N N . ASN A 1 24 ? -38.660 9.074 -62.746 1.00 11.40 ? 8 ASN A N 1 ATOM 42 C CA . ASN A 1 24 ? -38.771 10.341 -63.461 1.00 11.45 ? 8 ASN A CA 1 ATOM 43 C C . ASN A 1 24 ? -39.753 11.299 -62.794 1.00 11.46 ? 8 ASN A C 1 ATOM 44 O O . ASN A 1 24 ? -39.893 12.446 -63.215 1.00 13.33 ? 8 ASN A O 1 ATOM 45 C CB . ASN A 1 24 ? -39.167 10.108 -64.923 1.00 10.94 ? 8 ASN A CB 1 ATOM 46 C CG . ASN A 1 24 ? -40.541 9.480 -65.068 1.00 21.51 ? 8 ASN A CG 1 ATOM 47 O OD1 . ASN A 1 24 ? -41.343 9.487 -64.134 1.00 25.06 ? 8 ASN A OD1 1 ATOM 48 N ND2 . ASN A 1 24 ? -40.821 8.937 -66.247 1.00 27.63 ? 8 ASN A ND2 1 ATOM 49 N N . ARG A 1 25 ? -40.420 10.824 -61.748 1.00 14.91 ? 9 ARG A N 1 ATOM 50 C CA . ARG A 1 25 ? -41.339 11.656 -60.986 1.00 9.74 ? 9 ARG A CA 1 ATOM 51 C C . ARG A 1 25 ? -40.576 12.459 -59.937 1.00 7.89 ? 9 ARG A C 1 ATOM 52 O O . ARG A 1 25 ? -41.151 13.314 -59.264 1.00 11.25 ? 9 ARG A O 1 ATOM 53 C CB . ARG A 1 25 ? -42.407 10.792 -60.311 1.00 5.25 ? 9 ARG A CB 1 ATOM 54 C CG . ARG A 1 25 ? -43.832 11.169 -60.680 1.00 9.93 ? 9 ARG A CG 1 ATOM 55 C CD . ARG A 1 25 ? -44.672 9.935 -60.960 1.00 12.56 ? 9 ARG A CD 1 ATOM 56 N NE . ARG A 1 25 ? -44.350 8.841 -60.048 1.00 12.24 ? 9 ARG A NE 1 ATOM 57 C CZ . ARG A 1 25 ? -44.822 8.724 -58.810 1.00 11.99 ? 9 ARG A CZ 1 ATOM 58 N NH1 . ARG A 1 25 ? -45.646 9.635 -58.309 1.00 18.38 ? 9 ARG A NH1 1 ATOM 59 N NH2 . ARG A 1 25 ? -44.460 7.690 -58.065 1.00 18.24 ? 9 ARG A NH2 1 ATOM 60 N N . ASP A 1 26 ? -39.284 12.171 -59.792 1.00 5.51 ? 10 ASP A N 1 ATOM 61 C CA . ASP A 1 26 ? -38.478 12.794 -58.747 1.00 4.39 ? 10 ASP A CA 1 ATOM 62 C C . ASP A 1 26 ? -37.406 13.727 -59.318 1.00 4.93 ? 10 ASP A C 1 ATOM 63 O O . ASP A 1 26 ? -36.418 14.011 -58.651 1.00 8.54 ? 10 ASP A O 1 ATOM 64 C CB . ASP A 1 26 ? -37.828 11.717 -57.867 1.00 5.29 ? 10 ASP A CB 1 ATOM 65 C CG . ASP A 1 26 ? -38.807 11.090 -56.841 1.00 3.93 ? 10 ASP A CG 1 ATOM 66 O OD1 . ASP A 1 26 ? -39.583 11.831 -56.195 1.00 9.27 ? 10 ASP A OD1 1 ATOM 67 O OD2 . ASP A 1 26 ? -38.797 9.849 -56.662 1.00 5.65 ? 10 ASP A OD2 1 ATOM 68 N N . PHE A 1 27 ? -37.602 14.223 -60.537 1.00 2.87 ? 11 PHE A N 1 ATOM 69 C CA . PHE A 1 27 ? -36.716 15.255 -61.071 1.00 3.33 ? 11 PHE A CA 1 ATOM 70 C C . PHE A 1 27 ? -37.390 16.033 -62.190 1.00 3.93 ? 11 PHE A C 1 ATOM 71 O O . PHE A 1 27 ? -38.318 15.540 -62.832 1.00 4.74 ? 11 PHE A O 1 ATOM 72 C CB . PHE A 1 27 ? -35.398 14.651 -61.570 1.00 6.60 ? 11 PHE A CB 1 ATOM 73 C CG . PHE A 1 27 ? -35.515 13.935 -62.885 1.00 7.04 ? 11 PHE A CG 1 ATOM 74 C CD1 . PHE A 1 27 ? -35.489 14.643 -64.072 1.00 4.92 ? 11 PHE A CD1 1 ATOM 75 C CD2 . PHE A 1 27 ? -35.641 12.556 -62.935 1.00 6.82 ? 11 PHE A CD2 1 ATOM 76 C CE1 . PHE A 1 27 ? -35.592 13.996 -65.283 1.00 5.33 ? 11 PHE A CE1 1 ATOM 77 C CE2 . PHE A 1 27 ? -35.745 11.902 -64.148 1.00 5.99 ? 11 PHE A CE2 1 ATOM 78 C CZ . PHE A 1 27 ? -35.724 12.623 -65.323 1.00 6.08 ? 11 PHE A CZ 1 ATOM 79 N N . VAL A 1 28 ? -36.928 17.261 -62.397 1.00 5.32 ? 12 VAL A N 1 ATOM 80 C CA . VAL A 1 28 ? -37.405 18.089 -63.492 1.00 6.65 ? 12 VAL A CA 1 ATOM 81 C C . VAL A 1 28 ? -36.228 18.748 -64.194 1.00 9.66 ? 12 VAL A C 1 ATOM 82 O O . VAL A 1 28 ? -35.419 19.426 -63.562 1.00 12.32 ? 12 VAL A O 1 ATOM 83 C CB . VAL A 1 28 ? -38.373 19.188 -63.003 1.00 5.65 ? 12 VAL A CB 1 ATOM 84 C CG1 . VAL A 1 28 ? -39.617 18.571 -62.392 1.00 8.62 ? 12 VAL A CG1 1 ATOM 85 C CG2 . VAL A 1 28 ? -37.692 20.113 -62.002 1.00 10.44 ? 12 VAL A CG2 1 ATOM 86 N N . GLU A 1 29 ? -36.124 18.530 -65.499 1.00 7.16 ? 13 GLU A N 1 ATOM 87 C CA . GLU A 1 29 ? -35.160 19.257 -66.307 1.00 7.05 ? 13 GLU A CA 1 ATOM 88 C C . GLU A 1 29 ? -35.822 20.527 -66.810 1.00 7.87 ? 13 GLU A C 1 ATOM 89 O O . GLU A 1 29 ? -36.792 20.471 -67.565 1.00 11.59 ? 13 GLU A O 1 ATOM 90 C CB . GLU A 1 29 ? -34.685 18.423 -67.496 1.00 7.55 ? 13 GLU A CB 1 ATOM 91 C CG . GLU A 1 29 ? -33.647 19.140 -68.355 1.00 6.68 ? 13 GLU A CG 1 ATOM 92 C CD . GLU A 1 29 ? -33.469 18.514 -69.724 1.00 5.62 ? 13 GLU A CD 1 ATOM 93 O OE1 . GLU A 1 29 ? -32.625 19.012 -70.499 1.00 4.83 ? 13 GLU A OE1 1 ATOM 94 O OE2 . GLU A 1 29 ? -34.172 17.529 -70.027 1.00 9.73 ? 13 GLU A OE2 1 ATOM 95 N N . GLY A 1 30 ? -35.301 21.671 -66.387 1.00 5.46 ? 14 GLY A N 1 ATOM 96 C CA . GLY A 1 30 ? -35.852 22.944 -66.801 1.00 10.37 ? 14 GLY A CA 1 ATOM 97 C C . GLY A 1 30 ? -35.629 23.180 -68.279 1.00 10.77 ? 14 GLY A C 1 ATOM 98 O O . GLY A 1 30 ? -34.585 22.815 -68.821 1.00 11.25 ? 14 GLY A O 1 ATOM 99 N N . LEU A 1 31 ? -36.617 23.776 -68.938 1.00 5.86 ? 15 LEU A N 1 ATOM 100 C CA . LEU A 1 31 ? -36.449 24.204 -70.317 1.00 5.55 ? 15 LEU A CA 1 ATOM 101 C C . LEU A 1 31 ? -35.158 25.005 -70.353 1.00 12.94 ? 15 LEU A C 1 ATOM 102 O O . LEU A 1 31 ? -34.320 24.841 -71.241 1.00 13.05 ? 15 LEU A O 1 ATOM 103 C CB . LEU A 1 31 ? -37.628 25.074 -70.747 1.00 4.02 ? 15 LEU A CB 1 ATOM 104 C CG . LEU A 1 31 ? -37.866 25.279 -72.245 1.00 7.45 ? 15 LEU A CG 1 ATOM 105 C CD1 . LEU A 1 31 ? -38.224 26.735 -72.501 1.00 8.56 ? 15 LEU A CD1 1 ATOM 106 C CD2 . LEU A 1 31 ? -36.671 24.857 -73.086 1.00 10.93 ? 15 LEU A CD2 1 ATOM 107 N N . SER A 1 32 ? -35.011 25.867 -69.352 1.00 11.49 ? 16 SER A N 1 ATOM 108 C CA . SER A 1 32 ? -33.770 26.581 -69.095 1.00 7.41 ? 16 SER A CA 1 ATOM 109 C C . SER A 1 32 ? -33.485 26.457 -67.605 1.00 5.96 ? 16 SER A C 1 ATOM 110 O O . SER A 1 32 ? -34.375 26.114 -66.828 1.00 9.62 ? 16 SER A O 1 ATOM 111 C CB . SER A 1 32 ? -33.899 28.055 -69.481 1.00 5.89 ? 16 SER A CB 1 ATOM 112 O OG . SER A 1 32 ? -34.890 28.697 -68.700 1.00 10.47 ? 16 SER A OG 1 ATOM 113 N N . GLY A 1 33 ? -32.249 26.727 -67.204 1.00 8.82 ? 17 GLY A N 1 ATOM 114 C CA . GLY A 1 33 ? -31.890 26.673 -65.800 1.00 8.50 ? 17 GLY A CA 1 ATOM 115 C C . GLY A 1 33 ? -31.217 25.376 -65.396 1.00 10.05 ? 17 GLY A C 1 ATOM 116 O O . GLY A 1 33 ? -30.141 25.048 -65.895 1.00 17.08 ? 17 GLY A O 1 ATOM 117 N N . ALA A 1 34 ? -31.857 24.633 -64.496 1.00 5.82 ? 18 ALA A N 1 ATOM 118 C CA . ALA A 1 34 ? -31.218 23.484 -63.863 1.00 6.81 ? 18 ALA A CA 1 ATOM 119 C C . ALA A 1 34 ? -32.024 22.196 -63.982 1.00 5.19 ? 18 ALA A C 1 ATOM 120 O O . ALA A 1 34 ? -33.162 22.191 -64.451 1.00 5.06 ? 18 ALA A O 1 ATOM 121 C CB . ALA A 1 34 ? -30.973 23.788 -62.395 1.00 5.95 ? 18 ALA A CB 1 ATOM 122 N N . THR A 1 35 ? -31.401 21.102 -63.556 1.00 9.95 ? 19 THR A N 1 ATOM 123 C CA . THR A 1 35 ? -32.099 19.850 -63.308 1.00 7.02 ? 19 THR A CA 1 ATOM 124 C C . THR A 1 35 ? -32.170 19.644 -61.801 1.00 6.22 ? 19 THR A C 1 ATOM 125 O O . THR A 1 35 ? -31.141 19.487 -61.143 1.00 8.08 ? 19 THR A O 1 ATOM 126 C CB . THR A 1 35 ? -31.362 18.646 -63.918 1.00 6.67 ? 19 THR A CB 1 ATOM 127 O OG1 . THR A 1 35 ? -31.410 18.711 -65.347 1.00 12.47 ? 19 THR A OG1 1 ATOM 128 C CG2 . THR A 1 35 ? -31.999 17.340 -63.460 1.00 5.89 ? 19 THR A CG2 1 ATOM 129 N N . TRP A 1 36 ? -33.380 19.657 -61.255 1.00 5.72 ? 20 TRP A N 1 ATOM 130 C CA . TRP A 1 36 ? -33.569 19.473 -59.822 1.00 4.28 ? 20 TRP A CA 1 ATOM 131 C C . TRP A 1 36 ? -34.035 18.054 -59.526 1.00 4.54 ? 20 TRP A C 1 ATOM 132 O O . TRP A 1 36 ? -34.931 17.536 -60.191 1.00 3.79 ? 20 TRP A O 1 ATOM 133 C CB . TRP A 1 36 ? -34.572 20.493 -59.286 1.00 2.79 ? 20 TRP A CB 1 ATOM 134 C CG . TRP A 1 36 ? -34.013 21.884 -59.218 1.00 2.88 ? 20 TRP A CG 1 ATOM 135 C CD1 . TRP A 1 36 ? -32.714 22.254 -59.415 1.00 3.56 ? 20 TRP A CD1 1 ATOM 136 C CD2 . TRP A 1 36 ? -34.735 23.090 -58.936 1.00 4.54 ? 20 TRP A CD2 1 ATOM 137 N NE1 . TRP A 1 36 ? -32.582 23.614 -59.269 1.00 1.61 ? 20 TRP A NE1 1 ATOM 138 C CE2 . TRP A 1 36 ? -33.807 24.150 -58.979 1.00 3.89 ? 20 TRP A CE2 1 ATOM 139 C CE3 . TRP A 1 36 ? -36.073 23.376 -58.651 1.00 4.52 ? 20 TRP A CE3 1 ATOM 140 C CZ2 . TRP A 1 36 ? -34.175 25.471 -58.742 1.00 4.61 ? 20 TRP A CZ2 1 ATOM 141 C CZ3 . TRP A 1 36 ? -36.435 24.691 -58.419 1.00 3.50 ? 20 TRP A CZ3 1 ATOM 142 C CH2 . TRP A 1 36 ? -35.490 25.722 -58.467 1.00 2.27 ? 20 TRP A CH2 1 ATOM 143 N N . VAL A 1 37 ? -33.417 17.429 -58.529 1.00 6.35 ? 21 VAL A N 1 ATOM 144 C CA . VAL A 1 37 ? -33.681 16.029 -58.222 1.00 4.36 ? 21 VAL A CA 1 ATOM 145 C C . VAL A 1 37 ? -33.956 15.827 -56.735 1.00 5.28 ? 21 VAL A C 1 ATOM 146 O O . VAL A 1 37 ? -33.244 16.358 -55.884 1.00 7.93 ? 21 VAL A O 1 ATOM 147 C CB . VAL A 1 37 ? -32.480 15.149 -58.610 1.00 3.69 ? 21 VAL A CB 1 ATOM 148 C CG1 . VAL A 1 37 ? -32.831 13.680 -58.481 1.00 5.76 ? 21 VAL A CG1 1 ATOM 149 C CG2 . VAL A 1 37 ? -32.019 15.467 -60.021 1.00 4.35 ? 21 VAL A CG2 1 ATOM 150 N N . ASP A 1 38 ? -34.991 15.053 -56.428 1.00 4.48 ? 22 ASP A N 1 ATOM 151 C CA . ASP A 1 38 ? -35.294 14.689 -55.051 1.00 7.27 ? 22 ASP A CA 1 ATOM 152 C C . ASP A 1 38 ? -34.804 13.276 -54.761 1.00 6.98 ? 22 ASP A C 1 ATOM 153 O O . ASP A 1 38 ? -35.073 12.349 -55.525 1.00 8.76 ? 22 ASP A O 1 ATOM 154 C CB . ASP A 1 38 ? -36.798 14.770 -54.790 1.00 7.19 ? 22 ASP A CB 1 ATOM 155 C CG . ASP A 1 38 ? -37.314 16.192 -54.796 1.00 5.85 ? 22 ASP A CG 1 ATOM 156 O OD1 . ASP A 1 38 ? -36.493 17.125 -54.671 1.00 6.08 ? 22 ASP A OD1 1 ATOM 157 O OD2 . ASP A 1 38 ? -38.543 16.379 -54.919 1.00 6.52 ? 22 ASP A OD2 1 ATOM 158 N N . VAL A 1 39 ? -34.077 13.115 -53.661 1.00 7.05 ? 23 VAL A N 1 ATOM 159 C CA . VAL A 1 39 ? -33.645 11.793 -53.230 1.00 6.88 ? 23 VAL A CA 1 ATOM 160 C C . VAL A 1 39 ? -33.736 11.671 -51.715 1.00 5.74 ? 23 VAL A C 1 ATOM 161 O O . VAL A 1 39 ? -33.499 12.637 -50.991 1.00 7.28 ? 23 VAL A O 1 ATOM 162 C CB . VAL A 1 39 ? -32.197 11.490 -53.667 1.00 4.90 ? 23 VAL A CB 1 ATOM 163 C CG1 . VAL A 1 39 ? -31.989 11.855 -55.130 1.00 7.14 ? 23 VAL A CG1 1 ATOM 164 C CG2 . VAL A 1 39 ? -31.205 12.237 -52.793 1.00 5.45 ? 23 VAL A CG2 1 ATOM 165 N N . VAL A 1 40 ? -34.089 10.481 -51.243 1.00 6.98 ? 24 VAL A N 1 ATOM 166 C CA . VAL A 1 40 ? -34.118 10.207 -49.814 1.00 9.80 ? 24 VAL A CA 1 ATOM 167 C C . VAL A 1 40 ? -33.025 9.204 -49.471 1.00 10.52 ? 24 VAL A C 1 ATOM 168 O O . VAL A 1 40 ? -33.049 8.065 -49.938 1.00 9.44 ? 24 VAL A O 1 ATOM 169 C CB . VAL A 1 40 ? -35.477 9.637 -49.374 1.00 9.11 ? 24 VAL A CB 1 ATOM 170 C CG1 . VAL A 1 40 ? -35.524 9.504 -47.861 1.00 9.73 ? 24 VAL A CG1 1 ATOM 171 C CG2 . VAL A 1 40 ? -36.613 10.522 -49.869 1.00 8.79 ? 24 VAL A CG2 1 ATOM 172 N N . LEU A 1 41 ? -32.065 9.631 -48.658 1.00 8.39 ? 25 LEU A N 1 ATOM 173 C CA . LEU A 1 41 ? -30.961 8.765 -48.265 1.00 9.38 ? 25 LEU A CA 1 ATOM 174 C C . LEU A 1 41 ? -31.250 8.126 -46.911 1.00 9.93 ? 25 LEU A C 1 ATOM 175 O O . LEU A 1 41 ? -31.650 8.803 -45.964 1.00 11.52 ? 25 LEU A O 1 ATOM 176 C CB . LEU A 1 41 ? -29.653 9.554 -48.203 1.00 9.57 ? 25 LEU A CB 1 ATOM 177 C CG . LEU A 1 41 ? -29.365 10.459 -49.402 1.00 6.16 ? 25 LEU A CG 1 ATOM 178 C CD1 . LEU A 1 41 ? -28.074 11.221 -49.177 1.00 5.31 ? 25 LEU A CD1 1 ATOM 179 C CD2 . LEU A 1 41 ? -29.295 9.658 -50.691 1.00 4.72 ? 25 LEU A CD2 1 ATOM 180 N N . GLU A 1 42 ? -31.057 6.814 -46.834 1.00 15.45 ? 26 GLU A N 1 ATOM 181 C CA . GLU A 1 42 ? -31.283 6.068 -45.605 1.00 10.11 ? 26 GLU A CA 1 ATOM 182 C C . GLU A 1 42 ? -30.093 5.153 -45.359 1.00 13.56 ? 26 GLU A C 1 ATOM 183 O O . GLU A 1 42 ? -29.434 4.722 -46.305 1.00 9.11 ? 26 GLU A O 1 ATOM 184 C CB . GLU A 1 42 ? -32.564 5.242 -45.724 1.00 17.47 ? 26 GLU A CB 1 ATOM 185 C CG . GLU A 1 42 ? -33.821 6.077 -45.968 1.00 22.27 ? 26 GLU A CG 1 ATOM 186 C CD . GLU A 1 42 ? -34.859 5.364 -46.816 1.00 17.89 ? 26 GLU A CD 1 ATOM 187 O OE1 . GLU A 1 42 ? -34.495 4.417 -47.545 1.00 24.73 ? 26 GLU A OE1 1 ATOM 188 O OE2 . GLU A 1 42 ? -36.042 5.754 -46.754 1.00 15.80 ? 26 GLU A OE2 1 ATOM 189 N N . HIS A 1 43 ? -29.808 4.858 -44.095 1.00 15.30 ? 27 HIS A N 1 ATOM 190 C CA . HIS A 1 43 ? -28.673 4.003 -43.772 1.00 17.04 ? 27 HIS A CA 1 ATOM 191 C C . HIS A 1 43 ? -28.838 2.636 -44.429 1.00 15.97 ? 27 HIS A C 1 ATOM 192 O O . HIS A 1 43 ? -29.833 1.945 -44.206 1.00 14.46 ? 27 HIS A O 1 ATOM 193 C CB . HIS A 1 43 ? -28.514 3.839 -42.261 1.00 19.01 ? 27 HIS A CB 1 ATOM 194 C CG . HIS A 1 43 ? -27.363 2.961 -41.874 1.00 24.65 ? 27 HIS A CG 1 ATOM 195 N ND1 . HIS A 1 43 ? -26.049 3.342 -42.044 1.00 26.04 ? 27 HIS A ND1 1 ATOM 196 C CD2 . HIS A 1 43 ? -27.331 1.718 -41.344 1.00 25.04 ? 27 HIS A CD2 1 ATOM 197 C CE1 . HIS A 1 43 ? -25.257 2.372 -41.626 1.00 18.67 ? 27 HIS A CE1 1 ATOM 198 N NE2 . HIS A 1 43 ? -26.006 1.374 -41.197 1.00 22.46 ? 27 HIS A NE2 1 ATOM 199 N N . GLY A 1 44 ? -27.858 2.256 -45.242 1.00 18.16 ? 28 GLY A N 1 ATOM 200 C CA . GLY A 1 44 ? -27.901 0.995 -45.958 1.00 14.60 ? 28 GLY A CA 1 ATOM 201 C C . GLY A 1 44 ? -28.188 1.217 -47.429 1.00 19.93 ? 28 GLY A C 1 ATOM 202 O O . GLY A 1 44 ? -27.376 0.893 -48.294 1.00 24.96 ? 28 GLY A O 1 ATOM 203 N N . SER A 1 45 ? -29.362 1.772 -47.710 1.00 17.99 ? 29 SER A N 1 ATOM 204 C CA . SER A 1 45 ? -29.773 2.062 -49.081 1.00 17.26 ? 29 SER A CA 1 ATOM 205 C C . SER A 1 45 ? -28.783 2.987 -49.774 1.00 21.64 ? 29 SER A C 1 ATOM 206 O O . SER A 1 45 ? -27.989 3.669 -49.127 1.00 15.12 ? 29 SER A O 1 ATOM 207 C CB . SER A 1 45 ? -31.177 2.688 -49.108 1.00 16.44 ? 29 SER A CB 1 ATOM 208 O OG . SER A 1 45 ? -31.141 4.094 -48.925 1.00 20.95 ? 29 SER A OG 1 ATOM 209 N N . CYS A 1 46 ? -28.823 2.980 -51.101 1.00 14.09 ? 30 CYS A N 1 ATOM 210 C CA . CYS A 1 46 ? -28.112 3.969 -51.889 1.00 12.30 ? 30 CYS A CA 1 ATOM 211 C C . CYS A 1 46 ? -28.940 4.259 -53.130 1.00 15.37 ? 30 CYS A C 1 ATOM 212 O O . CYS A 1 46 ? -29.646 3.384 -53.629 1.00 15.61 ? 30 CYS A O 1 ATOM 213 C CB . CYS A 1 46 ? -26.713 3.476 -52.258 1.00 14.33 ? 30 CYS A CB 1 ATOM 214 S SG . CYS A 1 46 ? -26.666 2.209 -53.541 1.00 27.36 ? 30 CYS A SG 1 ATOM 215 N N . VAL A 1 47 ? -28.868 5.494 -53.612 1.00 16.81 ? 31 VAL A N 1 ATOM 216 C CA A VAL A 1 47 ? -29.662 5.925 -54.757 0.53 20.34 ? 31 VAL A CA 1 ATOM 217 C CA B VAL A 1 47 ? -29.660 5.898 -54.766 0.47 20.48 ? 31 VAL A CA 1 ATOM 218 C C . VAL A 1 47 ? -28.759 6.213 -55.951 1.00 11.39 ? 31 VAL A C 1 ATOM 219 O O . VAL A 1 47 ? -27.647 6.713 -55.786 1.00 10.60 ? 31 VAL A O 1 ATOM 220 C CB A VAL A 1 47 ? -30.465 7.195 -54.425 0.53 17.54 ? 31 VAL A CB 1 ATOM 221 C CB B VAL A 1 47 ? -30.552 7.114 -54.449 0.47 17.55 ? 31 VAL A CB 1 ATOM 222 C CG1 A VAL A 1 47 ? -31.556 7.418 -55.461 0.53 16.85 ? 31 VAL A CG1 1 ATOM 223 C CG1 B VAL A 1 47 ? -31.599 6.740 -53.412 0.47 13.77 ? 31 VAL A CG1 1 ATOM 224 C CG2 A VAL A 1 47 ? -31.061 7.094 -53.029 0.53 12.69 ? 31 VAL A CG2 1 ATOM 225 C CG2 B VAL A 1 47 ? -29.715 8.289 -53.973 0.47 14.59 ? 31 VAL A CG2 1 ATOM 226 N N . THR A 1 48 ? -29.240 5.903 -57.149 1.00 11.37 ? 32 THR A N 1 ATOM 227 C CA . THR A 1 48 ? -28.438 6.092 -58.350 1.00 15.38 ? 32 THR A CA 1 ATOM 228 C C . THR A 1 48 ? -29.237 6.664 -59.518 1.00 11.34 ? 32 THR A C 1 ATOM 229 O O . THR A 1 48 ? -30.451 6.481 -59.608 1.00 10.43 ? 32 THR A O 1 ATOM 230 C CB . THR A 1 48 ? -27.805 4.762 -58.802 1.00 13.99 ? 32 THR A CB 1 ATOM 231 O OG1 . THR A 1 48 ? -26.965 4.988 -59.940 1.00 14.96 ? 32 THR A OG1 1 ATOM 232 C CG2 . THR A 1 48 ? -28.881 3.750 -59.162 1.00 9.48 ? 32 THR A CG2 1 ATOM 233 N N . THR A 1 49 ? -28.542 7.359 -60.414 1.00 13.43 ? 33 THR A N 1 ATOM 234 C CA . THR A 1 49 ? -29.145 7.846 -61.652 1.00 14.40 ? 33 THR A CA 1 ATOM 235 C C . THR A 1 49 ? -28.084 8.037 -62.734 1.00 11.91 ? 33 THR A C 1 ATOM 236 O O . THR A 1 49 ? -26.893 7.864 -62.482 1.00 12.47 ? 33 THR A O 1 ATOM 237 C CB . THR A 1 49 ? -29.909 9.168 -61.443 1.00 13.34 ? 33 THR A CB 1 ATOM 238 O OG1 . THR A 1 49 ? -30.576 9.534 -62.657 1.00 11.94 ? 33 THR A OG1 1 ATOM 239 C CG2 . THR A 1 49 ? -28.963 10.286 -61.028 1.00 8.96 ? 33 THR A CG2 1 ATOM 240 N N . MET A 1 50 ? -28.527 8.403 -63.934 1.00 13.30 ? 34 MET A N 1 ATOM 241 C CA . MET A 1 50 ? -27.654 8.443 -65.101 1.00 9.24 ? 34 MET A CA 1 ATOM 242 C C . MET A 1 50 ? -28.192 9.457 -66.106 1.00 15.69 ? 34 MET A C 1 ATOM 243 O O . MET A 1 50 ? -29.402 9.659 -66.200 1.00 15.17 ? 34 MET A O 1 ATOM 244 C CB . MET A 1 50 ? -27.593 7.051 -65.730 1.00 13.85 ? 34 MET A CB 1 ATOM 245 C CG . MET A 1 50 ? -26.584 6.883 -66.848 1.00 16.37 ? 34 MET A CG 1 ATOM 246 S SD . MET A 1 50 ? -26.875 5.341 -67.740 1.00 36.44 ? 34 MET A SD 1 ATOM 247 C CE . MET A 1 50 ? -25.338 5.148 -68.639 1.00 37.50 ? 34 MET A CE 1 ATOM 248 N N . ALA A 1 51 ? -27.296 10.095 -66.852 1.00 15.00 ? 35 ALA A N 1 ATOM 249 C CA . ALA A 1 51 ? -27.690 11.149 -67.784 1.00 15.15 ? 35 ALA A CA 1 ATOM 250 C C . ALA A 1 51 ? -27.469 10.744 -69.239 1.00 21.96 ? 35 ALA A C 1 ATOM 251 O O . ALA A 1 51 ? -26.867 9.707 -69.522 1.00 23.61 ? 35 ALA A O 1 ATOM 252 C CB . ALA A 1 51 ? -26.929 12.419 -67.475 1.00 15.27 ? 35 ALA A CB 1 ATOM 253 N N . LYS A 1 52 ? -27.961 11.572 -70.158 1.00 32.76 ? 36 LYS A N 1 ATOM 254 C CA . LYS A 1 52 ? -27.795 11.318 -71.587 1.00 34.34 ? 36 LYS A CA 1 ATOM 255 C C . LYS A 1 52 ? -26.328 11.047 -71.922 1.00 33.39 ? 36 LYS A C 1 ATOM 256 O O . LYS A 1 52 ? -25.565 11.968 -72.220 1.00 43.93 ? 36 LYS A O 1 ATOM 257 C CB . LYS A 1 52 ? -28.336 12.483 -72.436 1.00 33.68 ? 36 LYS A CB 1 ATOM 258 C CG . LYS A 1 52 ? -28.329 13.846 -71.758 1.00 34.47 ? 36 LYS A CG 1 ATOM 259 C CD . LYS A 1 52 ? -28.423 14.984 -72.774 1.00 28.67 ? 36 LYS A CD 1 ATOM 260 C CE . LYS A 1 52 ? -29.832 15.177 -73.330 1.00 20.92 ? 36 LYS A CE 1 ATOM 261 N NZ . LYS A 1 52 ? -30.436 16.479 -72.910 1.00 3.86 ? 36 LYS A NZ 1 ATOM 262 N N . ASP A 1 53 ? -25.949 9.773 -71.869 1.00 33.84 ? 37 ASP A N 1 ATOM 263 C CA . ASP A 1 53 ? -24.582 9.346 -72.167 1.00 28.70 ? 37 ASP A CA 1 ATOM 264 C C . ASP A 1 53 ? -23.560 9.926 -71.187 1.00 31.90 ? 37 ASP A C 1 ATOM 265 O O . ASP A 1 53 ? -22.724 10.752 -71.555 1.00 31.22 ? 37 ASP A O 1 ATOM 266 C CB . ASP A 1 53 ? -24.203 9.696 -73.609 1.00 36.45 ? 37 ASP A CB 1 ATOM 267 C CG . ASP A 1 53 ? -24.425 8.540 -74.567 1.00 40.85 ? 37 ASP A CG 1 ATOM 268 O OD1 . ASP A 1 53 ? -25.382 7.763 -74.356 1.00 42.30 ? 37 ASP A OD1 1 ATOM 269 O OD2 . ASP A 1 53 ? -23.641 8.403 -75.529 1.00 38.85 ? 37 ASP A OD2 1 ATOM 270 N N . LYS A 1 54 ? -23.639 9.478 -69.938 1.00 33.32 ? 38 LYS A N 1 ATOM 271 C CA . LYS A 1 54 ? -22.669 9.843 -68.913 1.00 20.68 ? 38 LYS A CA 1 ATOM 272 C C . LYS A 1 54 ? -22.553 8.693 -67.917 1.00 19.26 ? 38 LYS A C 1 ATOM 273 O O . LYS A 1 54 ? -23.359 7.763 -67.947 1.00 19.63 ? 38 LYS A O 1 ATOM 274 C CB . LYS A 1 54 ? -23.092 11.128 -68.198 1.00 18.63 ? 38 LYS A CB 1 ATOM 275 C CG . LYS A 1 54 ? -22.950 12.387 -69.037 1.00 19.42 ? 38 LYS A CG 1 ATOM 276 C CD . LYS A 1 54 ? -23.362 13.621 -68.250 1.00 19.18 ? 38 LYS A CD 1 ATOM 277 C CE . LYS A 1 54 ? -23.386 14.868 -69.120 1.00 32.11 ? 38 LYS A CE 1 ATOM 278 N NZ . LYS A 1 54 ? -22.067 15.554 -69.170 1.00 36.59 ? 38 LYS A NZ 1 ATOM 279 N N . PRO A 1 55 ? -21.546 8.746 -67.030 1.00 21.09 ? 39 PRO A N 1 ATOM 280 C CA . PRO A 1 55 ? -21.356 7.656 -66.067 1.00 19.77 ? 39 PRO A CA 1 ATOM 281 C C . PRO A 1 55 ? -22.494 7.580 -65.055 1.00 19.27 ? 39 PRO A C 1 ATOM 282 O O . PRO A 1 55 ? -23.238 8.546 -64.893 1.00 21.75 ? 39 PRO A O 1 ATOM 283 C CB . PRO A 1 55 ? -20.044 8.027 -65.362 1.00 20.14 ? 39 PRO A CB 1 ATOM 284 C CG . PRO A 1 55 ? -19.406 9.078 -66.217 1.00 17.16 ? 39 PRO A CG 1 ATOM 285 C CD . PRO A 1 55 ? -20.530 9.798 -66.875 1.00 23.54 ? 39 PRO A CD 1 ATOM 286 N N . THR A 1 56 ? -22.628 6.439 -64.387 1.00 22.67 ? 40 THR A N 1 ATOM 287 C CA . THR A 1 56 ? -23.645 6.274 -63.357 1.00 16.10 ? 40 THR A CA 1 ATOM 288 C C . THR A 1 56 ? -23.296 7.110 -62.130 1.00 15.70 ? 40 THR A C 1 ATOM 289 O O . THR A 1 56 ? -22.123 7.298 -61.808 1.00 15.62 ? 40 THR A O 1 ATOM 290 C CB . THR A 1 56 ? -23.794 4.798 -62.946 1.00 16.92 ? 40 THR A CB 1 ATOM 291 O OG1 . THR A 1 56 ? -24.345 4.051 -64.039 1.00 24.55 ? 40 THR A OG1 1 ATOM 292 C CG2 . THR A 1 56 ? -24.708 4.662 -61.734 1.00 11.54 ? 40 THR A CG2 1 ATOM 293 N N . LEU A 1 57 ? -24.325 7.608 -61.453 1.00 14.02 ? 41 LEU A N 1 ATOM 294 C CA . LEU A 1 57 ? -24.139 8.469 -60.293 1.00 11.77 ? 41 LEU A CA 1 ATOM 295 C C . LEU A 1 57 ? -24.800 7.848 -59.073 1.00 14.35 ? 41 LEU A C 1 ATOM 296 O O . LEU A 1 57 ? -26.002 7.595 -59.081 1.00 14.06 ? 41 LEU A O 1 ATOM 297 C CB . LEU A 1 57 ? -24.744 9.847 -60.565 1.00 11.74 ? 41 LEU A CB 1 ATOM 298 C CG . LEU A 1 57 ? -24.484 10.932 -59.520 1.00 9.62 ? 41 LEU A CG 1 ATOM 299 C CD1 . LEU A 1 57 ? -22.995 11.200 -59.377 1.00 9.49 ? 41 LEU A CD1 1 ATOM 300 C CD2 . LEU A 1 57 ? -25.224 12.205 -59.894 1.00 8.19 ? 41 LEU A CD2 1 ATOM 301 N N . ASP A 1 58 ? -24.014 7.606 -58.027 1.00 9.53 ? 42 ASP A N 1 ATOM 302 C CA . ASP A 1 58 ? -24.533 7.013 -56.799 1.00 10.86 ? 42 ASP A CA 1 ATOM 303 C C . ASP A 1 58 ? -24.399 7.966 -55.616 1.00 12.39 ? 42 ASP A C 1 ATOM 304 O O . ASP A 1 58 ? -23.376 8.629 -55.452 1.00 14.41 ? 42 ASP A O 1 ATOM 305 C CB . ASP A 1 58 ? -23.801 5.706 -56.479 1.00 13.57 ? 42 ASP A CB 1 ATOM 306 C CG . ASP A 1 58 ? -23.989 4.651 -57.551 1.00 13.13 ? 42 ASP A CG 1 ATOM 307 O OD1 . ASP A 1 58 ? -24.903 4.802 -58.388 1.00 15.97 ? 42 ASP A OD1 1 ATOM 308 O OD2 . ASP A 1 58 ? -23.227 3.661 -57.551 1.00 16.72 ? 42 ASP A OD2 1 ATOM 309 N N . ILE A 1 59 ? -25.443 8.025 -54.796 1.00 14.46 ? 43 ILE A N 1 ATOM 310 C CA . ILE A 1 59 ? -25.418 8.792 -53.555 1.00 10.76 ? 43 ILE A CA 1 ATOM 311 C C . ILE A 1 59 ? -25.728 7.852 -52.396 1.00 13.06 ? 43 ILE A C 1 ATOM 312 O O . ILE A 1 59 ? -26.521 6.921 -52.543 1.00 9.49 ? 43 ILE A O 1 ATOM 313 C CB . ILE A 1 59 ? -26.464 9.922 -53.556 1.00 8.81 ? 43 ILE A CB 1 ATOM 314 C CG1 . ILE A 1 59 ? -26.476 10.653 -54.901 1.00 15.08 ? 43 ILE A CG1 1 ATOM 315 C CG2 . ILE A 1 59 ? -26.190 10.891 -52.416 1.00 10.53 ? 43 ILE A CG2 1 ATOM 316 C CD1 . ILE A 1 59 ? -25.202 11.406 -55.203 1.00 23.58 ? 43 ILE A CD1 1 ATOM 317 N N . GLU A 1 60 ? -25.108 8.091 -51.245 1.00 12.58 ? 44 GLU A N 1 ATOM 318 C CA . GLU A 1 60 ? -25.311 7.223 -50.091 1.00 7.66 ? 44 GLU A CA 1 ATOM 319 C C . GLU A 1 60 ? -24.947 7.911 -48.780 1.00 7.42 ? 44 GLU A C 1 ATOM 320 O O . GLU A 1 60 ? -23.947 8.622 -48.693 1.00 11.66 ? 44 GLU A O 1 ATOM 321 C CB . GLU A 1 60 ? -24.487 5.943 -50.247 1.00 12.64 ? 44 GLU A CB 1 ATOM 322 C CG . GLU A 1 60 ? -24.649 4.956 -49.099 1.00 13.71 ? 44 GLU A CG 1 ATOM 323 C CD . GLU A 1 60 ? -23.780 3.725 -49.255 1.00 9.79 ? 44 GLU A CD 1 ATOM 324 O OE1 . GLU A 1 60 ? -23.225 3.520 -50.355 1.00 20.44 ? 44 GLU A OE1 1 ATOM 325 O OE2 . GLU A 1 60 ? -23.650 2.961 -48.276 1.00 15.01 ? 44 GLU A OE2 1 ATOM 326 N N . LEU A 1 61 ? -25.771 7.688 -47.761 1.00 11.93 ? 45 LEU A N 1 ATOM 327 C CA . LEU A 1 61 ? -25.508 8.200 -46.422 1.00 8.30 ? 45 LEU A CA 1 ATOM 328 C C . LEU A 1 61 ? -24.626 7.213 -45.668 1.00 8.57 ? 45 LEU A C 1 ATOM 329 O O . LEU A 1 61 ? -25.026 6.076 -45.420 1.00 9.56 ? 45 LEU A O 1 ATOM 330 C CB . LEU A 1 61 ? -26.823 8.410 -45.669 1.00 7.02 ? 45 LEU A CB 1 ATOM 331 C CG . LEU A 1 61 ? -26.713 8.769 -44.186 1.00 4.14 ? 45 LEU A CG 1 ATOM 332 C CD1 . LEU A 1 61 ? -25.890 10.029 -43.995 1.00 4.60 ? 45 LEU A CD1 1 ATOM 333 C CD2 . LEU A 1 61 ? -28.097 8.938 -43.584 1.00 7.51 ? 45 LEU A CD2 1 ATOM 334 N N . LEU A 1 62 ? -23.423 7.650 -45.310 1.00 11.27 ? 46 LEU A N 1 ATOM 335 C CA . LEU A 1 62 ? -22.451 6.770 -44.669 1.00 9.46 ? 46 LEU A CA 1 ATOM 336 C C . LEU A 1 62 ? -22.642 6.673 -43.154 1.00 12.32 ? 46 LEU A C 1 ATOM 337 O O . LEU A 1 62 ? -22.619 5.576 -42.598 1.00 18.69 ? 46 LEU A O 1 ATOM 338 C CB . LEU A 1 62 ? -21.026 7.214 -45.009 1.00 8.64 ? 46 LEU A CB 1 ATOM 339 C CG . LEU A 1 62 ? -20.617 7.044 -46.477 1.00 11.58 ? 46 LEU A CG 1 ATOM 340 C CD1 . LEU A 1 62 ? -19.145 7.377 -46.674 1.00 18.04 ? 46 LEU A CD1 1 ATOM 341 C CD2 . LEU A 1 62 ? -20.909 5.635 -46.968 1.00 12.96 ? 46 LEU A CD2 1 ATOM 342 N N . LYS A 1 63 ? -22.828 7.805 -42.483 1.00 9.00 ? 47 LYS A N 1 ATOM 343 C CA . LYS A 1 63 ? -23.109 7.771 -41.050 1.00 11.34 ? 47 LYS A CA 1 ATOM 344 C C . LYS A 1 63 ? -23.712 9.068 -40.518 1.00 8.91 ? 47 LYS A C 1 ATOM 345 O O . LYS A 1 63 ? -23.757 10.085 -41.209 1.00 6.05 ? 47 LYS A O 1 ATOM 346 C CB . LYS A 1 63 ? -21.844 7.426 -40.255 1.00 14.77 ? 47 LYS A CB 1 ATOM 347 C CG . LYS A 1 63 ? -20.845 8.562 -40.117 1.00 16.98 ? 47 LYS A CG 1 ATOM 348 C CD . LYS A 1 63 ? -19.867 8.287 -38.984 1.00 23.75 ? 47 LYS A CD 1 ATOM 349 C CE . LYS A 1 63 ? -19.289 6.880 -39.063 1.00 29.61 ? 47 LYS A CE 1 ATOM 350 N NZ . LYS A 1 63 ? -18.290 6.622 -37.990 1.00 41.44 ? 47 LYS A NZ 1 ATOM 351 N N . THR A 1 64 ? -24.174 9.003 -39.273 1.00 12.11 ? 48 THR A N 1 ATOM 352 C CA . THR A 1 64 ? -24.788 10.135 -38.595 1.00 9.99 ? 48 THR A CA 1 ATOM 353 C C . THR A 1 64 ? -24.252 10.205 -37.170 1.00 11.94 ? 48 THR A C 1 ATOM 354 O O . THR A 1 64 ? -24.350 9.236 -36.419 1.00 17.71 ? 48 THR A O 1 ATOM 355 C CB . THR A 1 64 ? -26.314 9.980 -38.550 1.00 11.73 ? 48 THR A CB 1 ATOM 356 O OG1 . THR A 1 64 ? -26.822 9.896 -39.886 1.00 6.47 ? 48 THR A OG1 1 ATOM 357 C CG2 . THR A 1 64 ? -26.956 11.160 -37.843 1.00 12.45 ? 48 THR A CG2 1 ATOM 358 N N . GLU A 1 65 ? -23.684 11.350 -36.802 1.00 11.47 ? 49 GLU A N 1 ATOM 359 C CA . GLU A 1 65 ? -23.006 11.482 -35.518 1.00 8.82 ? 49 GLU A CA 1 ATOM 360 C C . GLU A 1 65 ? -23.508 12.662 -34.696 1.00 5.55 ? 49 GLU A C 1 ATOM 361 O O . GLU A 1 65 ? -23.649 13.773 -35.205 1.00 6.40 ? 49 GLU A O 1 ATOM 362 C CB . GLU A 1 65 ? -21.501 11.644 -35.737 1.00 9.60 ? 49 GLU A CB 1 ATOM 363 C CG . GLU A 1 65 ? -20.843 10.462 -36.419 1.00 21.23 ? 49 GLU A CG 1 ATOM 364 C CD . GLU A 1 65 ? -19.431 10.768 -36.878 1.00 23.71 ? 49 GLU A CD 1 ATOM 365 O OE1 . GLU A 1 65 ? -18.493 10.608 -36.069 1.00 27.31 ? 49 GLU A OE1 1 ATOM 366 O OE2 . GLU A 1 65 ? -19.259 11.169 -38.048 1.00 26.83 ? 49 GLU A OE2 1 ATOM 367 N N . VAL A 1 66 ? -23.770 12.407 -33.418 1.00 8.52 ? 50 VAL A N 1 ATOM 368 C CA . VAL A 1 66 ? -23.983 13.473 -32.448 1.00 8.27 ? 50 VAL A CA 1 ATOM 369 C C . VAL A 1 66 ? -22.692 13.652 -31.663 1.00 7.34 ? 50 VAL A C 1 ATOM 370 O O . VAL A 1 66 ? -22.216 12.716 -31.023 1.00 11.59 ? 50 VAL A O 1 ATOM 371 C CB . VAL A 1 66 ? -25.130 13.148 -31.474 1.00 8.49 ? 50 VAL A CB 1 ATOM 372 C CG1 . VAL A 1 66 ? -25.171 14.167 -30.340 1.00 6.87 ? 50 VAL A CG1 1 ATOM 373 C CG2 . VAL A 1 66 ? -26.461 13.105 -32.213 1.00 5.52 ? 50 VAL A CG2 1 ATOM 374 N N . THR A 1 67 ? -22.125 14.854 -31.712 1.00 11.37 ? 51 THR A N 1 ATOM 375 C CA . THR A 1 67 ? -20.811 15.097 -31.126 1.00 7.21 ? 51 THR A CA 1 ATOM 376 C C . THR A 1 67 ? -20.818 16.244 -30.119 1.00 7.15 ? 51 THR A C 1 ATOM 377 O O . THR A 1 67 ? -21.287 17.343 -30.415 1.00 10.16 ? 51 THR A O 1 ATOM 378 C CB . THR A 1 67 ? -19.758 15.384 -32.218 1.00 8.53 ? 51 THR A CB 1 ATOM 379 O OG1 . THR A 1 67 ? -18.604 15.994 -31.627 1.00 15.32 ? 51 THR A OG1 1 ATOM 380 C CG2 . THR A 1 67 ? -20.324 16.307 -33.285 1.00 14.82 ? 51 THR A CG2 1 ATOM 381 N N . ASN A 1 68 ? -20.296 15.967 -28.927 1.00 11.88 ? 52 ASN A N 1 ATOM 382 C CA . ASN A 1 68 ? -20.173 16.966 -27.869 1.00 8.09 ? 52 ASN A CA 1 ATOM 383 C C . ASN A 1 68 ? -21.477 17.690 -27.555 1.00 5.63 ? 52 ASN A C 1 ATOM 384 O O . ASN A 1 68 ? -21.536 18.918 -27.604 1.00 8.12 ? 52 ASN A O 1 ATOM 385 C CB . ASN A 1 68 ? -19.090 17.987 -28.225 1.00 7.82 ? 52 ASN A CB 1 ATOM 386 C CG . ASN A 1 68 ? -17.689 17.441 -28.038 1.00 8.66 ? 52 ASN A CG 1 ATOM 387 O OD1 . ASN A 1 68 ? -17.406 16.731 -27.074 1.00 17.61 ? 52 ASN A OD1 1 ATOM 388 N ND2 . ASN A 1 68 ? -16.805 17.771 -28.965 1.00 8.00 ? 52 ASN A ND2 1 ATOM 389 N N . PRO A 1 69 ? -22.532 16.927 -27.235 1.00 6.16 ? 53 PRO A N 1 ATOM 390 C CA . PRO A 1 69 ? -23.782 17.538 -26.770 1.00 4.94 ? 53 PRO A CA 1 ATOM 391 C C . PRO A 1 69 ? -23.622 18.157 -25.384 1.00 6.10 ? 53 PRO A C 1 ATOM 392 O O . PRO A 1 69 ? -22.786 17.703 -24.603 1.00 8.11 ? 53 PRO A O 1 ATOM 393 C CB . PRO A 1 69 ? -24.760 16.360 -26.735 1.00 3.27 ? 53 PRO A CB 1 ATOM 394 C CG . PRO A 1 69 ? -23.905 15.146 -26.640 1.00 3.50 ? 53 PRO A CG 1 ATOM 395 C CD . PRO A 1 69 ? -22.648 15.467 -27.382 1.00 3.25 ? 53 PRO A CD 1 ATOM 396 N N . ALA A 1 70 ? -24.418 19.180 -25.088 1.00 7.64 ? 54 ALA A N 1 ATOM 397 C CA . ALA A 1 70 ? -24.294 19.911 -23.832 1.00 6.61 ? 54 ALA A CA 1 ATOM 398 C C . ALA A 1 70 ? -25.040 19.210 -22.704 1.00 6.45 ? 54 ALA A C 1 ATOM 399 O O . ALA A 1 70 ? -26.104 18.632 -22.919 1.00 5.60 ? 54 ALA A O 1 ATOM 400 C CB . ALA A 1 70 ? -24.811 21.332 -23.999 1.00 5.65 ? 54 ALA A CB 1 ATOM 401 N N . VAL A 1 71 ? -24.478 19.271 -21.500 1.00 10.37 ? 55 VAL A N 1 ATOM 402 C CA . VAL A 1 71 ? -25.117 18.687 -20.327 1.00 4.89 ? 55 VAL A CA 1 ATOM 403 C C . VAL A 1 71 ? -26.241 19.583 -19.822 1.00 4.82 ? 55 VAL A C 1 ATOM 404 O O . VAL A 1 71 ? -26.067 20.791 -19.661 1.00 4.92 ? 55 VAL A O 1 ATOM 405 C CB . VAL A 1 71 ? -24.110 18.463 -19.182 1.00 4.62 ? 55 VAL A CB 1 ATOM 406 C CG1 . VAL A 1 71 ? -24.826 17.988 -17.924 1.00 4.61 ? 55 VAL A CG1 1 ATOM 407 C CG2 . VAL A 1 71 ? -23.047 17.460 -19.601 1.00 5.36 ? 55 VAL A CG2 1 ATOM 408 N N . LEU A 1 72 ? -27.397 18.977 -19.577 1.00 4.91 ? 56 LEU A N 1 ATOM 409 C CA . LEU A 1 72 ? -28.546 19.686 -19.035 1.00 5.08 ? 56 LEU A CA 1 ATOM 410 C C . LEU A 1 72 ? -28.408 19.735 -17.516 1.00 8.60 ? 56 LEU A C 1 ATOM 411 O O . LEU A 1 72 ? -28.348 20.809 -16.917 1.00 6.13 ? 56 LEU A O 1 ATOM 412 C CB . LEU A 1 72 ? -29.833 18.964 -19.438 1.00 7.58 ? 56 LEU A CB 1 ATOM 413 C CG . LEU A 1 72 ? -31.161 19.715 -19.337 1.00 14.02 ? 56 LEU A CG 1 ATOM 414 C CD1 . LEU A 1 72 ? -31.096 21.058 -20.048 1.00 13.24 ? 56 LEU A CD1 1 ATOM 415 C CD2 . LEU A 1 72 ? -32.268 18.855 -19.927 1.00 7.55 ? 56 LEU A CD2 1 ATOM 416 N N . ARG A 1 73 ? -28.354 18.556 -16.907 1.00 9.88 ? 57 ARG A N 1 ATOM 417 C CA . ARG A 1 73 ? -28.044 18.418 -15.492 1.00 5.63 ? 57 ARG A CA 1 ATOM 418 C C . ARG A 1 73 ? -27.169 17.188 -15.304 1.00 8.37 ? 57 ARG A C 1 ATOM 419 O O . ARG A 1 73 ? -27.004 16.385 -16.221 1.00 9.53 ? 57 ARG A O 1 ATOM 420 C CB . ARG A 1 73 ? -29.317 18.237 -14.663 1.00 4.25 ? 57 ARG A CB 1 ATOM 421 C CG . ARG A 1 73 ? -30.298 19.396 -14.680 1.00 4.55 ? 57 ARG A CG 1 ATOM 422 C CD . ARG A 1 73 ? -31.576 18.988 -13.966 1.00 5.74 ? 57 ARG A CD 1 ATOM 423 N NE . ARG A 1 73 ? -32.520 20.087 -13.798 1.00 8.29 ? 57 ARG A NE 1 ATOM 424 C CZ . ARG A 1 73 ? -33.723 19.955 -13.246 1.00 4.35 ? 57 ARG A CZ 1 ATOM 425 N NH1 . ARG A 1 73 ? -34.128 18.771 -12.809 1.00 4.51 ? 57 ARG A NH1 1 ATOM 426 N NH2 . ARG A 1 73 ? -34.522 21.005 -13.128 1.00 7.21 ? 57 ARG A NH2 1 ATOM 427 N N . LYS A 1 74 ? -26.604 17.053 -14.110 1.00 11.09 ? 58 LYS A N 1 ATOM 428 C CA . LYS A 1 74 ? -25.983 15.807 -13.686 1.00 9.25 ? 58 LYS A CA 1 ATOM 429 C C . LYS A 1 74 ? -26.735 15.320 -12.459 1.00 9.28 ? 58 LYS A C 1 ATOM 430 O O . LYS A 1 74 ? -26.988 16.095 -11.538 1.00 12.13 ? 58 LYS A O 1 ATOM 431 C CB . LYS A 1 74 ? -24.512 16.012 -13.329 1.00 6.57 ? 58 LYS A CB 1 ATOM 432 C CG . LYS A 1 74 ? -23.647 16.515 -14.464 1.00 12.29 ? 58 LYS A CG 1 ATOM 433 C CD . LYS A 1 74 ? -22.231 16.766 -13.980 1.00 23.26 ? 58 LYS A CD 1 ATOM 434 C CE . LYS A 1 74 ? -21.499 17.752 -14.869 1.00 23.44 ? 58 LYS A CE 1 ATOM 435 N NZ . LYS A 1 74 ? -20.271 18.270 -14.206 1.00 32.62 ? 58 LYS A NZ 1 ATOM 436 N N . LEU A 1 75 ? -27.102 14.044 -12.450 1.00 7.83 ? 59 LEU A N 1 ATOM 437 C CA . LEU A 1 75 ? -27.810 13.466 -11.316 1.00 9.66 ? 59 LEU A CA 1 ATOM 438 C C . LEU A 1 75 ? -26.886 12.519 -10.565 1.00 8.86 ? 59 LEU A C 1 ATOM 439 O O . LEU A 1 75 ? -26.000 11.905 -11.158 1.00 7.69 ? 59 LEU A O 1 ATOM 440 C CB . LEU A 1 75 ? -29.061 12.719 -11.784 1.00 6.55 ? 59 LEU A CB 1 ATOM 441 C CG . LEU A 1 75 ? -29.973 13.457 -12.766 1.00 4.70 ? 59 LEU A CG 1 ATOM 442 C CD1 . LEU A 1 75 ? -31.296 12.725 -12.903 1.00 8.90 ? 59 LEU A CD1 1 ATOM 443 C CD2 . LEU A 1 75 ? -30.208 14.889 -12.324 1.00 8.30 ? 59 LEU A CD2 1 ATOM 444 N N . CYS A 1 76 ? -27.095 12.403 -9.257 1.00 9.93 ? 60 CYS A N 1 ATOM 445 C CA . CYS A 1 76 ? -26.254 11.556 -8.421 1.00 10.92 ? 60 CYS A CA 1 ATOM 446 C C . CYS A 1 76 ? -26.997 10.279 -8.051 1.00 8.19 ? 60 CYS A C 1 ATOM 447 O O . CYS A 1 76 ? -28.069 10.326 -7.448 1.00 9.26 ? 60 CYS A O 1 ATOM 448 C CB . CYS A 1 76 ? -25.832 12.304 -7.154 1.00 9.79 ? 60 CYS A CB 1 ATOM 449 S SG . CYS A 1 76 ? -24.415 11.578 -6.301 1.00 12.01 ? 60 CYS A SG 1 ATOM 450 N N . ILE A 1 77 ? -26.420 9.141 -8.422 1.00 9.00 ? 61 ILE A N 1 ATOM 451 C CA . ILE A 1 77 ? -27.027 7.842 -8.153 1.00 7.04 ? 61 ILE A CA 1 ATOM 452 C C . ILE A 1 77 ? -26.323 7.122 -7.006 1.00 10.52 ? 61 ILE A C 1 ATOM 453 O O . ILE A 1 77 ? -26.794 6.091 -6.528 1.00 13.58 ? 61 ILE A O 1 ATOM 454 C CB . ILE A 1 77 ? -27.005 6.946 -9.407 1.00 12.81 ? 61 ILE A CB 1 ATOM 455 C CG1 . ILE A 1 77 ? -25.565 6.568 -9.777 1.00 11.35 ? 61 ILE A CG1 1 ATOM 456 C CG2 . ILE A 1 77 ? -27.702 7.654 -10.566 1.00 9.63 ? 61 ILE A CG2 1 ATOM 457 C CD1 . ILE A 1 77 ? -25.466 5.659 -10.980 1.00 13.31 ? 61 ILE A CD1 1 ATOM 458 N N . GLU A 1 78 ? -25.193 7.668 -6.568 1.00 9.75 ? 62 GLU A N 1 ATOM 459 C CA . GLU A 1 78 ? -24.449 7.092 -5.456 1.00 7.51 ? 62 GLU A CA 1 ATOM 460 C C . GLU A 1 78 ? -23.645 8.175 -4.752 1.00 8.00 ? 62 GLU A C 1 ATOM 461 O O . GLU A 1 78 ? -22.683 8.702 -5.308 1.00 9.15 ? 62 GLU A O 1 ATOM 462 C CB . GLU A 1 78 ? -23.508 5.995 -5.951 1.00 11.16 ? 62 GLU A CB 1 ATOM 463 C CG . GLU A 1 78 ? -22.872 5.189 -4.834 1.00 11.34 ? 62 GLU A CG 1 ATOM 464 C CD . GLU A 1 78 ? -21.848 4.195 -5.342 1.00 15.55 ? 62 GLU A CD 1 ATOM 465 O OE1 . GLU A 1 78 ? -21.438 4.308 -6.516 1.00 17.45 ? 62 GLU A OE1 1 ATOM 466 O OE2 . GLU A 1 78 ? -21.453 3.299 -4.566 1.00 26.39 ? 62 GLU A OE2 1 ATOM 467 N N . ALA A 1 79 ? -24.046 8.504 -3.528 1.00 10.84 ? 63 ALA A N 1 ATOM 468 C CA . ALA A 1 79 ? -23.363 9.525 -2.743 1.00 7.40 ? 63 ALA A CA 1 ATOM 469 C C . ALA A 1 79 ? -22.687 8.901 -1.528 1.00 7.19 ? 63 ALA A C 1 ATOM 470 O O . ALA A 1 79 ? -23.000 7.775 -1.144 1.00 14.63 ? 63 ALA A O 1 ATOM 471 C CB . ALA A 1 79 ? -24.349 10.589 -2.302 1.00 8.48 ? 63 ALA A CB 1 ATOM 472 N N . LYS A 1 80 ? -21.761 9.642 -0.928 1.00 12.14 ? 64 LYS A N 1 ATOM 473 C CA . LYS A 1 80 ? -21.107 9.207 0.299 1.00 10.81 ? 64 LYS A CA 1 ATOM 474 C C . LYS A 1 80 ? -21.163 10.317 1.341 1.00 7.95 ? 64 LYS A C 1 ATOM 475 O O . LYS A 1 80 ? -21.360 11.485 1.006 1.00 10.56 ? 64 LYS A O 1 ATOM 476 C CB . LYS A 1 80 ? -19.656 8.802 0.030 1.00 19.34 ? 64 LYS A CB 1 ATOM 477 C CG . LYS A 1 80 ? -18.775 9.928 -0.484 1.00 18.36 ? 64 LYS A CG 1 ATOM 478 C CD . LYS A 1 80 ? -17.337 9.464 -0.659 1.00 23.36 ? 64 LYS A CD 1 ATOM 479 C CE . LYS A 1 80 ? -16.374 10.636 -0.761 1.00 36.84 ? 64 LYS A CE 1 ATOM 480 N NZ . LYS A 1 80 ? -16.196 11.333 0.545 1.00 38.93 ? 64 LYS A NZ 1 ATOM 481 N N . ILE A 1 81 ? -20.986 9.944 2.604 1.00 9.22 ? 65 ILE A N 1 ATOM 482 C CA . ILE A 1 81 ? -21.105 10.886 3.711 1.00 8.17 ? 65 ILE A CA 1 ATOM 483 C C . ILE A 1 81 ? -19.848 10.875 4.576 1.00 15.47 ? 65 ILE A C 1 ATOM 484 O O . ILE A 1 81 ? -19.245 9.824 4.797 1.00 14.26 ? 65 ILE A O 1 ATOM 485 C CB . ILE A 1 81 ? -22.326 10.545 4.587 1.00 9.27 ? 65 ILE A CB 1 ATOM 486 C CG1 . ILE A 1 81 ? -23.623 10.913 3.861 1.00 10.46 ? 65 ILE A CG1 1 ATOM 487 C CG2 . ILE A 1 81 ? -22.249 11.265 5.922 1.00 13.26 ? 65 ILE A CG2 1 ATOM 488 C CD1 . ILE A 1 81 ? -23.820 12.407 3.647 1.00 12.12 ? 65 ILE A CD1 1 ATOM 489 N N . SER A 1 82 ? -19.455 12.049 5.061 1.00 14.18 ? 66 SER A N 1 ATOM 490 C CA . SER A 1 82 ? -18.299 12.160 5.943 1.00 11.78 ? 66 SER A CA 1 ATOM 491 C C . SER A 1 82 ? -18.280 13.507 6.661 1.00 15.25 ? 66 SER A C 1 ATOM 492 O O . SER A 1 82 ? -19.120 14.369 6.408 1.00 12.61 ? 66 SER A O 1 ATOM 493 C CB . SER A 1 82 ? -17.003 11.964 5.154 1.00 13.89 ? 66 SER A CB 1 ATOM 494 O OG . SER A 1 82 ? -16.822 12.991 4.196 1.00 20.14 ? 66 SER A OG 1 ATOM 495 N N . ASN A 1 83 ? -17.314 13.680 7.557 1.00 16.59 ? 67 ASN A N 1 ATOM 496 C CA . ASN A 1 83 ? -17.199 14.904 8.341 1.00 12.42 ? 67 ASN A CA 1 ATOM 497 C C . ASN A 1 83 ? -18.486 15.230 9.092 1.00 7.26 ? 67 ASN A C 1 ATOM 498 O O . ASN A 1 83 ? -18.814 16.399 9.300 1.00 12.24 ? 67 ASN A O 1 ATOM 499 C CB . ASN A 1 83 ? -16.806 16.079 7.442 1.00 16.08 ? 67 ASN A CB 1 ATOM 500 C CG . ASN A 1 83 ? -15.482 15.854 6.730 1.00 18.99 ? 67 ASN A CG 1 ATOM 501 O OD1 . ASN A 1 83 ? -15.366 14.954 5.904 1.00 21.37 ? 67 ASN A OD1 1 ATOM 502 N ND2 . ASN A 1 83 ? -14.478 16.676 7.044 1.00 25.92 ? 67 ASN A ND2 1 ATOM 503 N N . THR A 1 84 ? -19.210 14.192 9.499 1.00 5.44 ? 68 THR A N 1 ATOM 504 C CA . THR A 1 84 ? -20.427 14.368 10.279 1.00 7.32 ? 68 THR A CA 1 ATOM 505 C C . THR A 1 84 ? -20.117 15.133 11.559 1.00 12.32 ? 68 THR A C 1 ATOM 506 O O . THR A 1 84 ? -19.362 14.660 12.407 1.00 11.94 ? 68 THR A O 1 ATOM 507 C CB . THR A 1 84 ? -21.059 13.014 10.648 1.00 7.28 ? 68 THR A CB 1 ATOM 508 O OG1 . THR A 1 84 ? -21.457 12.325 9.455 1.00 9.39 ? 68 THR A OG1 1 ATOM 509 C CG2 . THR A 1 84 ? -22.274 13.213 11.542 1.00 11.39 ? 68 THR A CG2 1 ATOM 510 N N . THR A 1 85 ? -20.709 16.316 11.694 1.00 13.50 ? 69 THR A N 1 ATOM 511 C CA . THR A 1 85 ? -20.469 17.166 12.851 1.00 9.09 ? 69 THR A CA 1 ATOM 512 C C . THR A 1 85 ? -21.790 17.503 13.532 1.00 7.65 ? 69 THR A C 1 ATOM 513 O O . THR A 1 85 ? -22.777 17.808 12.864 1.00 7.08 ? 69 THR A O 1 ATOM 514 C CB . THR A 1 85 ? -19.772 18.477 12.446 1.00 5.99 ? 69 THR A CB 1 ATOM 515 O OG1 . THR A 1 85 ? -18.918 18.245 11.320 1.00 13.63 ? 69 THR A OG1 1 ATOM 516 C CG2 . THR A 1 85 ? -18.952 19.018 13.600 1.00 5.59 ? 69 THR A CG2 1 ATOM 517 N N . THR A 1 86 ? -21.805 17.443 14.860 1.00 8.89 ? 70 THR A N 1 ATOM 518 C CA . THR A 1 86 ? -23.007 17.751 15.627 1.00 6.73 ? 70 THR A CA 1 ATOM 519 C C . THR A 1 86 ? -22.709 18.761 16.727 1.00 7.43 ? 70 THR A C 1 ATOM 520 O O . THR A 1 86 ? -21.647 18.727 17.349 1.00 11.39 ? 70 THR A O 1 ATOM 521 C CB . THR A 1 86 ? -23.598 16.487 16.277 1.00 6.29 ? 70 THR A CB 1 ATOM 522 O OG1 . THR A 1 86 ? -23.907 15.524 15.263 1.00 5.48 ? 70 THR A OG1 1 ATOM 523 C CG2 . THR A 1 86 ? -24.865 16.821 17.053 1.00 5.13 ? 70 THR A CG2 1 ATOM 524 N N . ASP A 1 87 ? -23.656 19.662 16.961 1.00 7.81 ? 71 ASP A N 1 ATOM 525 C CA . ASP A 1 87 ? -23.553 20.612 18.058 1.00 10.53 ? 71 ASP A CA 1 ATOM 526 C C . ASP A 1 87 ? -24.870 20.648 18.819 1.00 11.55 ? 71 ASP A C 1 ATOM 527 O O . ASP A 1 87 ? -25.929 20.872 18.232 1.00 9.00 ? 71 ASP A O 1 ATOM 528 C CB . ASP A 1 87 ? -23.216 22.009 17.540 1.00 8.61 ? 71 ASP A CB 1 ATOM 529 C CG . ASP A 1 87 ? -22.915 22.988 18.660 1.00 13.43 ? 71 ASP A CG 1 ATOM 530 O OD1 . ASP A 1 87 ? -22.321 22.568 19.676 1.00 14.65 ? 71 ASP A OD1 1 ATOM 531 O OD2 . ASP A 1 87 ? -23.275 24.176 18.525 1.00 17.96 ? 71 ASP A OD2 1 ATOM 532 N N . SER A 1 88 ? -24.797 20.424 20.127 1.00 9.37 ? 72 SER A N 1 ATOM 533 C CA . SER A 1 88 ? -25.985 20.416 20.967 1.00 7.88 ? 72 SER A CA 1 ATOM 534 C C . SER A 1 88 ? -25.857 21.449 22.078 1.00 10.07 ? 72 SER A C 1 ATOM 535 O O . SER A 1 88 ? -24.751 21.842 22.447 1.00 12.00 ? 72 SER A O 1 ATOM 536 C CB . SER A 1 88 ? -26.206 19.026 21.567 1.00 9.53 ? 72 SER A CB 1 ATOM 537 O OG . SER A 1 88 ? -25.159 18.670 22.453 1.00 20.43 ? 72 SER A OG 1 ATOM 538 N N . ARG A 1 89 ? -26.996 21.890 22.601 1.00 10.35 ? 73 ARG A N 1 ATOM 539 C CA A ARG A 1 89 ? -26.991 22.836 23.704 0.43 10.96 ? 73 ARG A CA 1 ATOM 540 C CA B ARG A 1 89 ? -27.041 22.896 23.659 0.57 10.97 ? 73 ARG A CA 1 ATOM 541 C C . ARG A 1 89 ? -28.082 22.518 24.711 1.00 8.88 ? 73 ARG A C 1 ATOM 542 O O . ARG A 1 89 ? -29.148 22.008 24.367 1.00 9.71 ? 73 ARG A O 1 ATOM 543 C CB A ARG A 1 89 ? -27.135 24.270 23.191 0.43 9.58 ? 73 ARG A CB 1 ATOM 544 C CB B ARG A 1 89 ? -27.418 24.258 23.072 0.57 9.44 ? 73 ARG A CB 1 ATOM 545 C CG A ARG A 1 89 ? -25.842 24.865 22.651 0.43 10.67 ? 73 ARG A CG 1 ATOM 546 C CG B ARG A 1 89 ? -26.483 24.778 21.995 0.57 9.11 ? 73 ARG A CG 1 ATOM 547 C CD A ARG A 1 89 ? -24.733 24.825 23.697 0.43 14.40 ? 73 ARG A CD 1 ATOM 548 C CD B ARG A 1 89 ? -25.253 25.439 22.590 0.57 11.06 ? 73 ARG A CD 1 ATOM 549 N NE A ARG A 1 89 ? -23.552 25.584 23.293 0.43 13.01 ? 73 ARG A NE 1 ATOM 550 N NE B ARG A 1 89 ? -24.449 26.107 21.570 0.57 11.38 ? 73 ARG A NE 1 ATOM 551 C CZ A ARG A 1 89 ? -22.548 25.099 22.566 0.43 12.52 ? 73 ARG A CZ 1 ATOM 552 C CZ B ARG A 1 89 ? -24.646 27.351 21.141 0.57 11.83 ? 73 ARG A CZ 1 ATOM 553 N NH1 A ARG A 1 89 ? -22.562 23.843 22.137 0.43 8.38 ? 73 ARG A NH1 1 ATOM 554 N NH1 B ARG A 1 89 ? -25.629 28.095 21.634 0.57 9.40 ? 73 ARG A NH1 1 ATOM 555 N NH2 A ARG A 1 89 ? -21.522 25.878 22.261 0.43 17.80 ? 73 ARG A NH2 1 ATOM 556 N NH2 B ARG A 1 89 ? -23.855 27.859 20.207 0.57 10.46 ? 73 ARG A NH2 1 ATOM 557 N N . CYS A 1 90 ? -27.788 22.797 25.975 1.00 10.20 ? 74 CYS A N 1 ATOM 558 C CA . CYS A 1 90 ? -28.740 22.544 27.045 1.00 10.14 ? 74 CYS A CA 1 ATOM 559 C C . CYS A 1 90 ? -29.937 23.475 26.893 1.00 12.36 ? 74 CYS A C 1 ATOM 560 O O . CYS A 1 90 ? -29.826 24.536 26.283 1.00 12.22 ? 74 CYS A O 1 ATOM 561 C CB . CYS A 1 90 ? -28.078 22.745 28.410 1.00 10.08 ? 74 CYS A CB 1 ATOM 562 S SG . CYS A 1 90 ? -26.915 21.439 28.874 1.00 3.50 ? 74 CYS A SG 1 ATOM 563 N N . PRO A 1 91 ? -31.089 23.074 27.447 1.00 9.42 ? 75 PRO A N 1 ATOM 564 C CA . PRO A 1 91 ? -32.344 23.824 27.349 1.00 9.20 ? 75 PRO A CA 1 ATOM 565 C C . PRO A 1 91 ? -32.182 25.331 27.548 1.00 12.88 ? 75 PRO A C 1 ATOM 566 O O . PRO A 1 91 ? -32.884 26.110 26.903 1.00 13.52 ? 75 PRO A O 1 ATOM 567 C CB . PRO A 1 91 ? -33.183 23.225 28.477 1.00 8.59 ? 75 PRO A CB 1 ATOM 568 C CG . PRO A 1 91 ? -32.729 21.812 28.550 1.00 5.39 ? 75 PRO A CG 1 ATOM 569 C CD . PRO A 1 91 ? -31.262 21.818 28.197 1.00 8.74 ? 75 PRO A CD 1 ATOM 570 N N . THR A 1 92 ? -31.272 25.730 28.431 1.00 15.81 ? 76 THR A N 1 ATOM 571 C CA . THR A 1 92 ? -31.086 27.141 28.755 1.00 11.22 ? 76 THR A CA 1 ATOM 572 C C . THR A 1 92 ? -29.799 27.710 28.163 1.00 12.21 ? 76 THR A C 1 ATOM 573 O O . THR A 1 92 ? -29.225 28.650 28.713 1.00 19.85 ? 76 THR A O 1 ATOM 574 C CB . THR A 1 92 ? -31.040 27.352 30.279 1.00 15.02 ? 76 THR A CB 1 ATOM 575 O OG1 . THR A 1 92 ? -29.878 26.711 30.820 1.00 14.76 ? 76 THR A OG1 1 ATOM 576 C CG2 . THR A 1 92 ? -32.284 26.780 30.938 1.00 12.76 ? 76 THR A CG2 1 ATOM 577 N N . GLN A 1 93 ? -29.348 27.143 27.047 1.00 13.86 ? 77 GLN A N 1 ATOM 578 C CA . GLN A 1 93 ? -28.089 27.559 26.433 1.00 6.14 ? 77 GLN A CA 1 ATOM 579 C C . GLN A 1 93 ? -28.251 28.019 24.985 1.00 9.32 ? 77 GLN A C 1 ATOM 580 O O . GLN A 1 93 ? -27.266 28.173 24.263 1.00 12.86 ? 77 GLN A O 1 ATOM 581 C CB . GLN A 1 93 ? -27.070 26.423 26.513 1.00 16.51 ? 77 GLN A CB 1 ATOM 582 C CG . GLN A 1 93 ? -26.267 26.417 27.800 1.00 16.56 ? 77 GLN A CG 1 ATOM 583 C CD . GLN A 1 93 ? -25.207 27.498 27.818 1.00 21.62 ? 77 GLN A CD 1 ATOM 584 O OE1 . GLN A 1 93 ? -25.504 28.674 28.024 1.00 29.83 ? 77 GLN A OE1 1 ATOM 585 N NE2 . GLN A 1 93 ? -23.960 27.106 27.586 1.00 11.94 ? 77 GLN A NE2 1 ATOM 586 N N . GLY A 1 94 ? -29.491 28.235 24.562 1.00 9.24 ? 78 GLY A N 1 ATOM 587 C CA . GLY A 1 94 ? -29.756 28.814 23.257 1.00 6.81 ? 78 GLY A CA 1 ATOM 588 C C . GLY A 1 94 ? -29.685 27.822 22.111 1.00 4.52 ? 78 GLY A C 1 ATOM 589 O O . GLY A 1 94 ? -29.666 26.609 22.322 1.00 8.12 ? 78 GLY A O 1 ATOM 590 N N . GLU A 1 95 ? -29.640 28.353 20.892 1.00 6.03 ? 79 GLU A N 1 ATOM 591 C CA . GLU A 1 95 ? -29.678 27.541 19.680 1.00 9.19 ? 79 GLU A CA 1 ATOM 592 C C . GLU A 1 95 ? -28.278 27.137 19.222 1.00 7.70 ? 79 GLU A C 1 ATOM 593 O O . GLU A 1 95 ? -27.424 27.990 18.981 1.00 9.92 ? 79 GLU A O 1 ATOM 594 C CB . GLU A 1 95 ? -30.389 28.316 18.564 1.00 8.88 ? 79 GLU A CB 1 ATOM 595 C CG . GLU A 1 95 ? -30.395 27.623 17.207 1.00 13.00 ? 79 GLU A CG 1 ATOM 596 C CD . GLU A 1 95 ? -31.120 28.427 16.143 1.00 17.79 ? 79 GLU A CD 1 ATOM 597 O OE1 . GLU A 1 95 ? -32.288 28.101 15.842 1.00 26.75 ? 79 GLU A OE1 1 ATOM 598 O OE2 . GLU A 1 95 ? -30.521 29.378 15.598 1.00 15.68 ? 79 GLU A OE2 1 ATOM 599 N N . ALA A 1 96 ? -28.053 25.831 19.109 1.00 8.10 ? 80 ALA A N 1 ATOM 600 C CA . ALA A 1 96 ? -26.796 25.296 18.597 1.00 8.17 ? 80 ALA A CA 1 ATOM 601 C C . ALA A 1 96 ? -26.428 25.934 17.261 1.00 12.71 ? 80 ALA A C 1 ATOM 602 O O . ALA A 1 96 ? -27.245 26.614 16.642 1.00 16.89 ? 80 ALA A O 1 ATOM 603 C CB . ALA A 1 96 ? -26.899 23.796 18.443 1.00 7.65 ? 80 ALA A CB 1 ATOM 604 N N . THR A 1 97 ? -25.198 25.699 16.813 1.00 15.52 ? 81 THR A N 1 ATOM 605 C CA . THR A 1 97 ? -24.701 26.328 15.595 1.00 11.46 ? 81 THR A CA 1 ATOM 606 C C . THR A 1 97 ? -23.405 25.692 15.107 1.00 8.92 ? 81 THR A C 1 ATOM 607 O O . THR A 1 97 ? -22.527 25.351 15.898 1.00 11.66 ? 81 THR A O 1 ATOM 608 C CB . THR A 1 97 ? -24.468 27.840 15.812 1.00 12.30 ? 81 THR A CB 1 ATOM 609 O OG1 . THR A 1 97 ? -25.623 28.570 15.379 1.00 17.47 ? 81 THR A OG1 1 ATOM 610 C CG2 . THR A 1 97 ? -23.249 28.326 15.036 1.00 13.96 ? 81 THR A CG2 1 ATOM 611 N N . LEU A 1 98 ? -23.304 25.535 13.791 1.00 6.27 ? 82 LEU A N 1 ATOM 612 C CA . LEU A 1 98 ? -22.083 25.060 13.153 1.00 4.79 ? 82 LEU A CA 1 ATOM 613 C C . LEU A 1 98 ? -21.713 26.016 12.026 1.00 10.70 ? 82 LEU A C 1 ATOM 614 O O . LEU A 1 98 ? -22.587 26.643 11.428 1.00 12.68 ? 82 LEU A O 1 ATOM 615 C CB . LEU A 1 98 ? -22.278 23.646 12.602 1.00 9.57 ? 82 LEU A CB 1 ATOM 616 C CG . LEU A 1 98 ? -22.395 22.513 13.624 1.00 6.02 ? 82 LEU A CG 1 ATOM 617 C CD1 . LEU A 1 98 ? -22.848 21.229 12.945 1.00 8.54 ? 82 LEU A CD1 1 ATOM 618 C CD2 . LEU A 1 98 ? -21.070 22.298 14.339 1.00 3.54 ? 82 LEU A CD2 1 ATOM 619 N N . VAL A 1 99 ? -20.419 26.139 11.747 1.00 13.81 ? 83 VAL A N 1 ATOM 620 C CA . VAL A 1 99 ? -19.957 27.006 10.667 1.00 10.02 ? 83 VAL A CA 1 ATOM 621 C C . VAL A 1 99 ? -20.150 26.342 9.309 1.00 7.64 ? 83 VAL A C 1 ATOM 622 O O . VAL A 1 99 ? -20.159 27.018 8.280 1.00 8.06 ? 83 VAL A O 1 ATOM 623 C CB . VAL A 1 99 ? -18.472 27.397 10.832 1.00 8.89 ? 83 VAL A CB 1 ATOM 624 C CG1 . VAL A 1 99 ? -18.268 28.156 12.134 1.00 6.81 ? 83 VAL A CG1 1 ATOM 625 C CG2 . VAL A 1 99 ? -17.565 26.166 10.763 1.00 10.70 ? 83 VAL A CG2 1 ATOM 626 N N . GLU A 1 100 ? -20.302 25.020 9.308 1.00 9.38 ? 84 GLU A N 1 ATOM 627 C CA . GLU A 1 100 ? -20.560 24.289 8.070 1.00 12.02 ? 84 GLU A CA 1 ATOM 628 C C . GLU A 1 100 ? -22.016 24.446 7.639 1.00 10.55 ? 84 GLU A C 1 ATOM 629 O O . GLU A 1 100 ? -22.412 23.955 6.581 1.00 11.63 ? 84 GLU A O 1 ATOM 630 C CB . GLU A 1 100 ? -20.196 22.800 8.185 1.00 7.34 ? 84 GLU A CB 1 ATOM 631 C CG . GLU A 1 100 ? -20.221 22.209 9.586 1.00 9.21 ? 84 GLU A CG 1 ATOM 632 C CD . GLU A 1 100 ? -18.922 22.437 10.335 1.00 8.33 ? 84 GLU A CD 1 ATOM 633 O OE1 . GLU A 1 100 ? -18.952 23.084 11.402 1.00 12.27 ? 84 GLU A OE1 1 ATOM 634 O OE2 . GLU A 1 100 ? -17.871 21.961 9.857 1.00 9.52 ? 84 GLU A OE2 1 ATOM 635 N N . GLU A 1 101 ? -22.807 25.132 8.458 1.00 9.02 ? 85 GLU A N 1 ATOM 636 C CA . GLU A 1 101 ? -24.162 25.503 8.073 1.00 10.46 ? 85 GLU A CA 1 ATOM 637 C C . GLU A 1 101 ? -24.114 26.362 6.814 1.00 16.62 ? 85 GLU A C 1 ATOM 638 O O . GLU A 1 101 ? -25.030 26.330 5.990 1.00 19.21 ? 85 GLU A O 1 ATOM 639 C CB . GLU A 1 101 ? -24.842 26.289 9.194 1.00 9.10 ? 85 GLU A CB 1 ATOM 640 C CG . GLU A 1 101 ? -26.132 25.681 9.705 1.00 8.92 ? 85 GLU A CG 1 ATOM 641 C CD . GLU A 1 101 ? -26.653 26.395 10.937 1.00 5.39 ? 85 GLU A CD 1 ATOM 642 O OE1 . GLU A 1 101 ? -25.827 26.807 11.778 1.00 12.10 ? 85 GLU A OE1 1 ATOM 643 O OE2 . GLU A 1 101 ? -27.885 26.553 11.062 1.00 8.28 ? 85 GLU A OE2 1 ATOM 644 N N . GLN A 1 102 ? -23.037 27.130 6.678 1.00 16.69 ? 86 GLN A N 1 ATOM 645 C CA . GLN A 1 102 ? -22.879 28.061 5.567 1.00 16.55 ? 86 GLN A CA 1 ATOM 646 C C . GLN A 1 102 ? -22.073 27.435 4.429 1.00 20.16 ? 86 GLN A C 1 ATOM 647 O O . GLN A 1 102 ? -21.797 28.086 3.421 1.00 21.56 ? 86 GLN A O 1 ATOM 648 C CB . GLN A 1 102 ? -22.181 29.333 6.053 1.00 13.73 ? 86 GLN A CB 1 ATOM 649 C CG . GLN A 1 102 ? -22.711 29.873 7.382 1.00 31.51 ? 86 GLN A CG 1 ATOM 650 C CD . GLN A 1 102 ? -23.964 30.711 7.225 1.00 38.64 ? 86 GLN A CD 1 ATOM 651 O OE1 . GLN A 1 102 ? -24.545 30.787 6.142 1.00 36.04 ? 86 GLN A OE1 1 ATOM 652 N NE2 . GLN A 1 102 ? -24.387 31.351 8.312 1.00 46.34 ? 86 GLN A NE2 1 ATOM 653 N N . ASP A 1 103 ? -21.699 26.169 4.593 1.00 20.49 ? 87 ASP A N 1 ATOM 654 C CA . ASP A 1 103 ? -20.928 25.455 3.581 1.00 13.79 ? 87 ASP A CA 1 ATOM 655 C C . ASP A 1 103 ? -21.877 24.626 2.724 1.00 13.88 ? 87 ASP A C 1 ATOM 656 O O . ASP A 1 103 ? -22.722 23.900 3.246 1.00 15.55 ? 87 ASP A O 1 ATOM 657 C CB . ASP A 1 103 ? -19.873 24.564 4.245 1.00 15.57 ? 87 ASP A CB 1 ATOM 658 C CG . ASP A 1 103 ? -18.915 23.945 3.246 1.00 18.57 ? 87 ASP A CG 1 ATOM 659 O OD1 . ASP A 1 103 ? -19.366 23.527 2.161 1.00 23.60 ? 87 ASP A OD1 1 ATOM 660 O OD2 . ASP A 1 103 ? -17.705 23.878 3.547 1.00 17.18 ? 87 ASP A OD2 1 ATOM 661 N N . THR A 1 104 ? -21.733 24.740 1.407 1.00 18.44 ? 88 THR A N 1 ATOM 662 C CA . THR A 1 104 ? -22.668 24.116 0.476 1.00 14.36 ? 88 THR A CA 1 ATOM 663 C C . THR A 1 104 ? -22.322 22.660 0.166 1.00 14.18 ? 88 THR A C 1 ATOM 664 O O . THR A 1 104 ? -23.118 21.944 -0.441 1.00 12.68 ? 88 THR A O 1 ATOM 665 C CB . THR A 1 104 ? -22.750 24.909 -0.841 1.00 13.71 ? 88 THR A CB 1 ATOM 666 O OG1 . THR A 1 104 ? -21.431 25.134 -1.353 1.00 19.16 ? 88 THR A OG1 1 ATOM 667 C CG2 . THR A 1 104 ? -23.438 26.249 -0.611 1.00 15.52 ? 88 THR A CG2 1 ATOM 668 N N . ASN A 1 105 ? -21.133 22.226 0.573 1.00 10.98 ? 89 ASN A N 1 ATOM 669 C CA . ASN A 1 105 ? -20.768 20.818 0.477 1.00 10.97 ? 89 ASN A CA 1 ATOM 670 C C . ASN A 1 105 ? -21.437 20.005 1.577 1.00 10.96 ? 89 ASN A C 1 ATOM 671 O O . ASN A 1 105 ? -21.479 18.778 1.517 1.00 12.05 ? 89 ASN A O 1 ATOM 672 C CB . ASN A 1 105 ? -19.251 20.648 0.565 1.00 14.37 ? 89 ASN A CB 1 ATOM 673 C CG . ASN A 1 105 ? -18.540 21.099 -0.694 1.00 23.60 ? 89 ASN A CG 1 ATOM 674 O OD1 . ASN A 1 105 ? -18.936 20.745 -1.804 1.00 23.07 ? 89 ASN A OD1 1 ATOM 675 N ND2 . ASN A 1 105 ? -17.484 21.890 -0.529 1.00 28.23 ? 89 ASN A ND2 1 ATOM 676 N N . PHE A 1 106 ? -21.967 20.700 2.578 1.00 15.80 ? 90 PHE A N 1 ATOM 677 C CA . PHE A 1 106 ? -22.563 20.044 3.736 1.00 7.72 ? 90 PHE A CA 1 ATOM 678 C C . PHE A 1 106 ? -24.086 20.067 3.698 1.00 9.99 ? 90 PHE A C 1 ATOM 679 O O . PHE A 1 106 ? -24.697 21.051 3.280 1.00 9.40 ? 90 PHE A O 1 ATOM 680 C CB . PHE A 1 106 ? -22.073 20.708 5.023 1.00 4.87 ? 90 PHE A CB 1 ATOM 681 C CG . PHE A 1 106 ? -20.689 20.291 5.430 1.00 7.39 ? 90 PHE A CG 1 ATOM 682 C CD1 . PHE A 1 106 ? -19.575 20.888 4.866 1.00 6.67 ? 90 PHE A CD1 1 ATOM 683 C CD2 . PHE A 1 106 ? -20.503 19.299 6.377 1.00 6.70 ? 90 PHE A CD2 1 ATOM 684 C CE1 . PHE A 1 106 ? -18.301 20.503 5.240 1.00 6.63 ? 90 PHE A CE1 1 ATOM 685 C CE2 . PHE A 1 106 ? -19.233 18.910 6.755 1.00 7.67 ? 90 PHE A CE2 1 ATOM 686 C CZ . PHE A 1 106 ? -18.131 19.512 6.185 1.00 8.03 ? 90 PHE A CZ 1 ATOM 687 N N . VAL A 1 107 ? -24.685 18.964 4.136 1.00 10.54 ? 91 VAL A N 1 ATOM 688 C CA . VAL A 1 107 ? -26.131 18.864 4.286 1.00 5.33 ? 91 VAL A CA 1 ATOM 689 C C . VAL A 1 107 ? -26.453 18.854 5.777 1.00 7.88 ? 91 VAL A C 1 ATOM 690 O O . VAL A 1 107 ? -25.935 18.028 6.526 1.00 9.07 ? 91 VAL A O 1 ATOM 691 C CB . VAL A 1 107 ? -26.691 17.594 3.602 1.00 5.97 ? 91 VAL A CB 1 ATOM 692 C CG1 . VAL A 1 107 ? -25.919 16.348 4.029 1.00 5.07 ? 91 VAL A CG1 1 ATOM 693 C CG2 . VAL A 1 107 ? -28.172 17.435 3.899 1.00 7.02 ? 91 VAL A CG2 1 ATOM 694 N N . CYS A 1 108 ? -27.299 19.786 6.204 1.00 7.99 ? 92 CYS A N 1 ATOM 695 C CA . CYS A 1 108 ? -27.539 20.003 7.627 1.00 5.02 ? 92 CYS A CA 1 ATOM 696 C C . CYS A 1 108 ? -28.973 19.687 8.040 1.00 3.56 ? 92 CYS A C 1 ATOM 697 O O . CYS A 1 108 ? -29.864 19.579 7.199 1.00 5.23 ? 92 CYS A O 1 ATOM 698 C CB . CYS A 1 108 ? -27.207 21.450 7.995 1.00 5.91 ? 92 CYS A CB 1 ATOM 699 S SG . CYS A 1 108 ? -25.456 21.866 7.852 1.00 5.23 ? 92 CYS A SG 1 ATOM 700 N N . ARG A 1 109 ? -29.185 19.542 9.345 1.00 6.20 ? 93 ARG A N 1 ATOM 701 C CA . ARG A 1 109 ? -30.517 19.286 9.886 1.00 10.56 ? 93 ARG A CA 1 ATOM 702 C C . ARG A 1 109 ? -30.619 19.712 11.347 1.00 5.25 ? 93 ARG A C 1 ATOM 703 O O . ARG A 1 109 ? -29.740 19.406 12.153 1.00 5.70 ? 93 ARG A O 1 ATOM 704 C CB . ARG A 1 109 ? -30.863 17.803 9.761 1.00 11.70 ? 93 ARG A CB 1 ATOM 705 C CG . ARG A 1 109 ? -32.324 17.492 10.039 1.00 13.31 ? 93 ARG A CG 1 ATOM 706 C CD . ARG A 1 109 ? -32.788 16.263 9.277 1.00 22.27 ? 93 ARG A CD 1 ATOM 707 N NE . ARG A 1 109 ? -32.571 16.403 7.839 1.00 20.48 ? 93 ARG A NE 1 ATOM 708 C CZ . ARG A 1 109 ? -32.898 15.484 6.936 1.00 22.63 ? 93 ARG A CZ 1 ATOM 709 N NH1 . ARG A 1 109 ? -33.464 14.344 7.311 1.00 20.90 ? 93 ARG A NH1 1 ATOM 710 N NH2 . ARG A 1 109 ? -32.658 15.706 5.651 1.00 16.54 ? 93 ARG A NH2 1 ATOM 711 N N . ARG A 1 110 ? -31.704 20.408 11.681 1.00 5.09 ? 94 ARG A N 1 ATOM 712 C CA . ARG A 1 110 ? -31.915 20.918 13.032 1.00 7.81 ? 94 ARG A CA 1 ATOM 713 C C . ARG A 1 110 ? -33.015 20.155 13.763 1.00 9.30 ? 94 ARG A C 1 ATOM 714 O O . ARG A 1 110 ? -33.913 19.588 13.140 1.00 7.97 ? 94 ARG A O 1 ATOM 715 C CB . ARG A 1 110 ? -32.280 22.402 12.987 1.00 4.17 ? 94 ARG A CB 1 ATOM 716 C CG . ARG A 1 110 ? -31.109 23.326 12.732 1.00 4.78 ? 94 ARG A CG 1 ATOM 717 C CD . ARG A 1 110 ? -31.494 24.772 12.983 1.00 5.62 ? 94 ARG A CD 1 ATOM 718 N NE . ARG A 1 110 ? -30.327 25.649 13.032 1.00 9.70 ? 94 ARG A NE 1 ATOM 719 C CZ . ARG A 1 110 ? -29.532 25.787 14.089 1.00 14.03 ? 94 ARG A CZ 1 ATOM 720 N NH1 . ARG A 1 110 ? -29.761 25.101 15.202 1.00 13.47 ? 94 ARG A NH1 1 ATOM 721 N NH2 . ARG A 1 110 ? -28.497 26.612 14.034 1.00 17.21 ? 94 ARG A NH2 1 ATOM 722 N N . THR A 1 111 ? -32.939 20.154 15.091 1.00 9.55 ? 95 THR A N 1 ATOM 723 C CA . THR A 1 111 ? -33.962 19.526 15.920 1.00 7.20 ? 95 THR A CA 1 ATOM 724 C C . THR A 1 111 ? -33.814 19.932 17.384 1.00 8.53 ? 95 THR A C 1 ATOM 725 O O . THR A 1 111 ? -32.969 20.755 17.735 1.00 9.61 ? 95 THR A O 1 ATOM 726 C CB . THR A 1 111 ? -33.894 17.986 15.842 1.00 5.81 ? 95 THR A CB 1 ATOM 727 O OG1 . THR A 1 111 ? -32.971 17.590 14.819 1.00 8.51 ? 95 THR A OG1 1 ATOM 728 C CG2 . THR A 1 111 ? -35.266 17.402 15.540 1.00 10.45 ? 95 THR A CG2 1 ATOM 729 N N . PHE A 1 112 ? -34.654 19.346 18.229 1.00 14.37 ? 96 PHE A N 1 ATOM 730 C CA . PHE A 1 112 ? -34.565 19.522 19.673 1.00 7.73 ? 96 PHE A CA 1 ATOM 731 C C . PHE A 1 112 ? -34.601 18.150 20.334 1.00 5.09 ? 96 PHE A C 1 ATOM 732 O O . PHE A 1 112 ? -35.540 17.383 20.125 1.00 5.18 ? 96 PHE A O 1 ATOM 733 C CB . PHE A 1 112 ? -35.728 20.370 20.191 1.00 8.78 ? 96 PHE A CB 1 ATOM 734 C CG . PHE A 1 112 ? -35.732 21.781 19.676 1.00 8.59 ? 96 PHE A CG 1 ATOM 735 C CD1 . PHE A 1 112 ? -36.310 22.089 18.456 1.00 13.08 ? 96 PHE A CD1 1 ATOM 736 C CD2 . PHE A 1 112 ? -35.163 22.801 20.418 1.00 8.99 ? 96 PHE A CD2 1 ATOM 737 C CE1 . PHE A 1 112 ? -36.315 23.389 17.984 1.00 16.18 ? 96 PHE A CE1 1 ATOM 738 C CE2 . PHE A 1 112 ? -35.165 24.101 19.952 1.00 15.87 ? 96 PHE A CE2 1 ATOM 739 C CZ . PHE A 1 112 ? -35.743 24.395 18.734 1.00 9.99 ? 96 PHE A CZ 1 ATOM 740 N N . VAL A 1 113 ? -33.579 17.845 21.126 1.00 8.75 ? 97 VAL A N 1 ATOM 741 C CA . VAL A 1 113 ? -33.478 16.545 21.782 1.00 7.31 ? 97 VAL A CA 1 ATOM 742 C C . VAL A 1 113 ? -33.626 16.681 23.290 1.00 10.06 ? 97 VAL A C 1 ATOM 743 O O . VAL A 1 113 ? -33.361 17.738 23.858 1.00 8.52 ? 97 VAL A O 1 ATOM 744 C CB . VAL A 1 113 ? -32.127 15.861 21.486 1.00 4.21 ? 97 VAL A CB 1 ATOM 745 C CG1 . VAL A 1 113 ? -31.990 15.583 20.001 1.00 7.58 ? 97 VAL A CG1 1 ATOM 746 C CG2 . VAL A 1 113 ? -30.963 16.712 21.994 1.00 5.10 ? 97 VAL A CG2 1 ATOM 747 N N . ASP A 1 114 ? -34.053 15.600 23.934 1.00 8.83 ? 98 ASP A N 1 ATOM 748 C CA . ASP A 1 114 ? -34.170 15.577 25.384 1.00 6.07 ? 98 ASP A CA 1 ATOM 749 C C . ASP A 1 114 ? -32.798 15.761 26.018 1.00 11.78 ? 98 ASP A C 1 ATOM 750 O O . ASP A 1 114 ? -31.866 15.011 25.727 1.00 12.16 ? 98 ASP A O 1 ATOM 751 C CB . ASP A 1 114 ? -34.769 14.251 25.857 1.00 15.33 ? 98 ASP A CB 1 ATOM 752 C CG . ASP A 1 114 ? -36.154 13.993 25.288 1.00 12.38 ? 98 ASP A CG 1 ATOM 753 O OD1 . ASP A 1 114 ? -36.477 14.552 24.220 1.00 15.18 ? 98 ASP A OD1 1 ATOM 754 O OD2 . ASP A 1 114 ? -36.920 13.227 25.912 1.00 10.35 ? 98 ASP A OD2 1 ATOM 755 N N . ARG A 1 115 ? -32.682 16.762 26.885 1.00 13.28 ? 99 ARG A N 1 ATOM 756 C CA . ARG A 1 115 ? -31.452 17.012 27.623 1.00 6.36 ? 99 ARG A CA 1 ATOM 757 C C . ARG A 1 115 ? -31.776 17.065 29.107 1.00 6.60 ? 99 ARG A C 1 ATOM 758 O O . ARG A 1 115 ? -32.894 17.407 29.487 1.00 11.04 ? 99 ARG A O 1 ATOM 759 C CB . ARG A 1 115 ? -30.824 18.335 27.185 1.00 6.34 ? 99 ARG A CB 1 ATOM 760 C CG . ARG A 1 115 ? -30.342 18.367 25.742 1.00 6.54 ? 99 ARG A CG 1 ATOM 761 C CD . ARG A 1 115 ? -29.330 17.267 25.451 1.00 7.98 ? 99 ARG A CD 1 ATOM 762 N NE . ARG A 1 115 ? -28.112 17.400 26.249 1.00 6.32 ? 99 ARG A NE 1 ATOM 763 C CZ . ARG A 1 115 ? -27.032 18.084 25.879 1.00 5.34 ? 99 ARG A CZ 1 ATOM 764 N NH1 . ARG A 1 115 ? -26.992 18.717 24.713 1.00 6.97 ? 99 ARG A NH1 1 ATOM 765 N NH2 . ARG A 1 115 ? -25.978 18.135 26.680 1.00 4.92 ? 99 ARG A NH2 1 ATOM 766 N N . GLY A 1 116 ? -30.801 16.733 29.947 1.00 6.19 ? 100 GLY A N 1 ATOM 767 C CA . GLY A 1 116 ? -31.012 16.736 31.381 1.00 6.11 ? 100 GLY A CA 1 ATOM 768 C C . GLY A 1 116 ? -29.765 16.374 32.163 1.00 5.94 ? 100 GLY A C 1 ATOM 769 O O . GLY A 1 116 ? -28.662 16.325 31.618 1.00 10.30 ? 100 GLY A O 1 ATOM 770 N N . HIS A 1 117 ? -29.950 16.116 33.453 1.00 3.85 ? 101 HIS A N 1 ATOM 771 C CA . HIS A 1 117 ? -28.851 15.783 34.350 1.00 6.84 ? 101 HIS A CA 1 ATOM 772 C C . HIS A 1 117 ? -27.994 14.656 33.782 1.00 5.10 ? 101 HIS A C 1 ATOM 773 O O . HIS A 1 117 ? -26.772 14.658 33.924 1.00 8.60 ? 101 HIS A O 1 ATOM 774 C CB . HIS A 1 117 ? -29.405 15.359 35.712 1.00 9.00 ? 101 HIS A CB 1 ATOM 775 C CG . HIS A 1 117 ? -30.268 16.393 36.368 1.00 13.10 ? 101 HIS A CG 1 ATOM 776 N ND1 . HIS A 1 117 ? -30.904 16.171 37.570 1.00 15.13 ? 101 HIS A ND1 1 ATOM 777 C CD2 . HIS A 1 117 ? -30.613 17.645 35.985 1.00 10.47 ? 101 HIS A CD2 1 ATOM 778 C CE1 . HIS A 1 117 ? -31.595 17.246 37.906 1.00 14.20 ? 101 HIS A CE1 1 ATOM 779 N NE2 . HIS A 1 117 ? -31.437 18.155 36.961 1.00 14.47 ? 101 HIS A NE2 1 ATOM 780 N N . GLY A 1 118 ? -28.645 13.694 33.138 1.00 3.50 ? 102 GLY A N 1 ATOM 781 C CA . GLY A 1 118 ? -27.964 12.516 32.633 1.00 5.11 ? 102 GLY A CA 1 ATOM 782 C C . GLY A 1 118 ? -26.939 12.801 31.550 1.00 11.75 ? 102 GLY A C 1 ATOM 783 O O . GLY A 1 118 ? -26.081 11.961 31.276 1.00 15.23 ? 102 GLY A O 1 ATOM 784 N N . ASN A 1 119 ? -27.023 13.974 30.930 1.00 8.44 ? 103 ASN A N 1 ATOM 785 C CA . ASN A 1 119 ? -26.075 14.347 29.885 1.00 7.21 ? 103 ASN A CA 1 ATOM 786 C C . ASN A 1 119 ? -25.534 15.770 30.039 1.00 5.03 ? 103 ASN A C 1 ATOM 787 O O . ASN A 1 119 ? -25.349 16.484 29.055 1.00 4.48 ? 103 ASN A O 1 ATOM 788 C CB . ASN A 1 119 ? -26.698 14.153 28.498 1.00 6.46 ? 103 ASN A CB 1 ATOM 789 C CG . ASN A 1 119 ? -28.159 14.550 28.451 1.00 6.28 ? 103 ASN A CG 1 ATOM 790 O OD1 . ASN A 1 119 ? -28.497 15.729 28.552 1.00 12.40 ? 103 ASN A OD1 1 ATOM 791 N ND2 . ASN A 1 119 ? -29.034 13.565 28.283 1.00 6.11 ? 103 ASN A ND2 1 ATOM 792 N N . GLY A 1 120 ? -25.285 16.173 31.281 1.00 6.87 ? 104 GLY A N 1 ATOM 793 C CA . GLY A 1 120 ? -24.559 17.400 31.553 1.00 4.64 ? 104 GLY A CA 1 ATOM 794 C C . GLY A 1 120 ? -25.408 18.643 31.745 1.00 8.84 ? 104 GLY A C 1 ATOM 795 O O . GLY A 1 120 ? -24.869 19.730 31.951 1.00 11.51 ? 104 GLY A O 1 ATOM 796 N N . CYS A 1 121 ? -26.728 18.497 31.694 1.00 11.77 ? 105 CYS A N 1 ATOM 797 C CA . CYS A 1 121 ? -27.616 19.653 31.805 1.00 7.79 ? 105 CYS A CA 1 ATOM 798 C C . CYS A 1 121 ? -28.233 19.757 33.196 1.00 7.55 ? 105 CYS A C 1 ATOM 799 O O . CYS A 1 121 ? -28.331 18.764 33.913 1.00 10.66 ? 105 CYS A O 1 ATOM 800 C CB . CYS A 1 121 ? -28.718 19.596 30.743 1.00 5.69 ? 105 CYS A CB 1 ATOM 801 S SG . CYS A 1 121 ? -28.125 19.820 29.057 1.00 3.34 ? 105 CYS A SG 1 ATOM 802 N N . GLY A 1 122 ? -28.649 20.964 33.568 1.00 5.99 ? 106 GLY A N 1 ATOM 803 C CA . GLY A 1 122 ? -29.231 21.209 34.877 1.00 10.54 ? 106 GLY A CA 1 ATOM 804 C C . GLY A 1 122 ? -30.739 21.047 34.872 1.00 12.06 ? 106 GLY A C 1 ATOM 805 O O . GLY A 1 122 ? -31.349 20.778 35.908 1.00 20.02 ? 106 GLY A O 1 ATOM 806 N N . LEU A 1 123 ? -31.340 21.220 33.699 1.00 15.13 ? 107 LEU A N 1 ATOM 807 C CA . LEU A 1 123 ? -32.782 21.079 33.541 1.00 10.38 ? 107 LEU A CA 1 ATOM 808 C C . LEU A 1 123 ? -33.128 19.946 32.588 1.00 10.75 ? 107 LEU A C 1 ATOM 809 O O . LEU A 1 123 ? -32.499 19.788 31.542 1.00 8.05 ? 107 LEU A O 1 ATOM 810 C CB . LEU A 1 123 ? -33.389 22.371 32.994 1.00 10.87 ? 107 LEU A CB 1 ATOM 811 C CG . LEU A 1 123 ? -33.454 23.586 33.918 1.00 25.83 ? 107 LEU A CG 1 ATOM 812 C CD1 . LEU A 1 123 ? -34.125 24.742 33.191 1.00 20.78 ? 107 LEU A CD1 1 ATOM 813 C CD2 . LEU A 1 123 ? -34.196 23.261 35.207 1.00 31.52 ? 107 LEU A CD2 1 ATOM 814 N N . PHE A 1 124 ? -34.132 19.157 32.954 1.00 12.41 ? 108 PHE A N 1 ATOM 815 C CA . PHE A 1 124 ? -34.724 18.214 32.018 1.00 8.37 ? 108 PHE A CA 1 ATOM 816 C C . PHE A 1 124 ? -35.589 18.994 31.039 1.00 10.89 ? 108 PHE A C 1 ATOM 817 O O . PHE A 1 124 ? -36.547 19.656 31.439 1.00 20.24 ? 108 PHE A O 1 ATOM 818 C CB . PHE A 1 124 ? -35.577 17.174 32.747 1.00 10.24 ? 108 PHE A CB 1 ATOM 819 C CG . PHE A 1 124 ? -34.780 16.198 33.567 1.00 7.78 ? 108 PHE A CG 1 ATOM 820 C CD1 . PHE A 1 124 ? -34.135 15.131 32.966 1.00 6.87 ? 108 PHE A CD1 1 ATOM 821 C CD2 . PHE A 1 124 ? -34.686 16.342 34.941 1.00 11.80 ? 108 PHE A CD2 1 ATOM 822 C CE1 . PHE A 1 124 ? -33.405 14.230 33.718 1.00 5.69 ? 108 PHE A CE1 1 ATOM 823 C CE2 . PHE A 1 124 ? -33.958 15.443 35.698 1.00 9.64 ? 108 PHE A CE2 1 ATOM 824 C CZ . PHE A 1 124 ? -33.318 14.386 35.085 1.00 4.34 ? 108 PHE A CZ 1 ATOM 825 N N . GLY A 1 125 ? -35.249 18.924 29.758 1.00 7.46 ? 109 GLY A N 1 ATOM 826 C CA . GLY A 1 125 ? -35.975 19.669 28.748 1.00 5.85 ? 109 GLY A CA 1 ATOM 827 C C . GLY A 1 125 ? -35.336 19.551 27.382 1.00 6.29 ? 109 GLY A C 1 ATOM 828 O O . GLY A 1 125 ? -34.269 18.958 27.232 1.00 5.69 ? 109 GLY A O 1 ATOM 829 N N . LYS A 1 126 ? -35.994 20.123 26.381 1.00 6.12 ? 110 LYS A N 1 ATOM 830 C CA . LYS A 1 126 ? -35.500 20.064 25.014 1.00 6.81 ? 110 LYS A CA 1 ATOM 831 C C . LYS A 1 126 ? -34.279 20.957 24.833 1.00 4.52 ? 110 LYS A C 1 ATOM 832 O O . LYS A 1 126 ? -34.303 22.138 25.179 1.00 4.90 ? 110 LYS A O 1 ATOM 833 C CB . LYS A 1 126 ? -36.595 20.492 24.037 1.00 5.71 ? 110 LYS A CB 1 ATOM 834 C CG . LYS A 1 126 ? -37.858 19.647 24.097 1.00 8.14 ? 110 LYS A CG 1 ATOM 835 C CD . LYS A 1 126 ? -37.578 18.189 23.771 1.00 9.78 ? 110 LYS A CD 1 ATOM 836 C CE . LYS A 1 126 ? -38.858 17.369 23.787 1.00 10.82 ? 110 LYS A CE 1 ATOM 837 N NZ . LYS A 1 126 ? -38.597 15.907 23.696 1.00 5.44 ? 110 LYS A NZ 1 ATOM 838 N N . GLY A 1 127 ? -33.212 20.379 24.293 1.00 4.26 ? 111 GLY A N 1 ATOM 839 C CA . GLY A 1 127 ? -32.017 21.126 23.955 1.00 5.43 ? 111 GLY A CA 1 ATOM 840 C C . GLY A 1 127 ? -31.831 21.147 22.452 1.00 7.62 ? 111 GLY A C 1 ATOM 841 O O . GLY A 1 127 ? -32.093 20.154 21.775 1.00 9.50 ? 111 GLY A O 1 ATOM 842 N N . SER A 1 128 ? -31.382 22.279 21.923 1.00 6.42 ? 112 SER A N 1 ATOM 843 C CA . SER A 1 128 ? -31.204 22.421 20.484 1.00 6.27 ? 112 SER A CA 1 ATOM 844 C C . SER A 1 128 ? -30.133 21.464 19.981 1.00 7.50 ? 112 SER A C 1 ATOM 845 O O . SER A 1 128 ? -29.247 21.057 20.731 1.00 8.29 ? 112 SER A O 1 ATOM 846 C CB . SER A 1 128 ? -30.823 23.858 20.126 1.00 9.67 ? 112 SER A CB 1 ATOM 847 O OG . SER A 1 128 ? -30.573 23.984 18.736 1.00 15.38 ? 112 SER A OG 1 ATOM 848 N N . LEU A 1 129 ? -30.226 21.102 18.707 1.00 9.27 ? 113 LEU A N 1 ATOM 849 C CA . LEU A 1 129 ? -29.236 20.233 18.087 1.00 5.98 ? 113 LEU A CA 1 ATOM 850 C C . LEU A 1 129 ? -29.173 20.468 16.583 1.00 5.66 ? 113 LEU A C 1 ATOM 851 O O . LEU A 1 129 ? -30.202 20.552 15.914 1.00 7.63 ? 113 LEU A O 1 ATOM 852 C CB . LEU A 1 129 ? -29.554 18.765 18.376 1.00 5.96 ? 113 LEU A CB 1 ATOM 853 C CG . LEU A 1 129 ? -28.455 17.774 17.983 1.00 7.99 ? 113 LEU A CG 1 ATOM 854 C CD1 . LEU A 1 129 ? -28.269 16.731 19.071 1.00 8.23 ? 113 LEU A CD1 1 ATOM 855 C CD2 . LEU A 1 129 ? -28.773 17.106 16.655 1.00 6.35 ? 113 LEU A CD2 1 ATOM 856 N N . ILE A 1 130 ? -27.954 20.578 16.066 1.00 7.40 ? 114 ILE A N 1 ATOM 857 C CA . ILE A 1 130 ? -27.719 20.768 14.640 1.00 7.86 ? 114 ILE A CA 1 ATOM 858 C C . ILE A 1 130 ? -26.672 19.768 14.177 1.00 5.88 ? 114 ILE A C 1 ATOM 859 O O . ILE A 1 130 ? -25.643 19.592 14.826 1.00 5.76 ? 114 ILE A O 1 ATOM 860 C CB . ILE A 1 130 ? -27.232 22.201 14.332 1.00 7.89 ? 114 ILE A CB 1 ATOM 861 C CG1 . ILE A 1 130 ? -26.806 22.334 12.867 1.00 6.05 ? 114 ILE A CG1 1 ATOM 862 C CG2 . ILE A 1 130 ? -26.074 22.577 15.242 1.00 9.91 ? 114 ILE A CG2 1 ATOM 863 C CD1 . ILE A 1 130 ? -27.953 22.303 11.890 1.00 5.55 ? 114 ILE A CD1 1 ATOM 864 N N . THR A 1 131 ? -26.938 19.112 13.054 1.00 6.92 ? 115 THR A N 1 ATOM 865 C CA . THR A 1 131 ? -26.021 18.115 12.522 1.00 5.34 ? 115 THR A CA 1 ATOM 866 C C . THR A 1 131 ? -25.756 18.354 11.042 1.00 4.83 ? 115 THR A C 1 ATOM 867 O O . THR A 1 131 ? -26.686 18.452 10.243 1.00 7.70 ? 115 THR A O 1 ATOM 868 C CB . THR A 1 131 ? -26.575 16.694 12.709 1.00 8.85 ? 115 THR A CB 1 ATOM 869 O OG1 . THR A 1 131 ? -26.712 16.415 14.107 1.00 12.65 ? 115 THR A OG1 1 ATOM 870 C CG2 . THR A 1 131 ? -25.645 15.667 12.081 1.00 5.13 ? 115 THR A CG2 1 ATOM 871 N N . CYS A 1 132 ? -24.479 18.440 10.687 1.00 5.38 ? 116 CYS A N 1 ATOM 872 C CA . CYS A 1 132 ? -24.072 18.665 9.308 1.00 5.95 ? 116 CYS A CA 1 ATOM 873 C C . CYS A 1 132 ? -23.138 17.556 8.852 1.00 3.92 ? 116 CYS A C 1 ATOM 874 O O . CYS A 1 132 ? -22.300 17.088 9.618 1.00 7.47 ? 116 CYS A O 1 ATOM 875 C CB . CYS A 1 132 ? -23.373 20.018 9.175 1.00 4.06 ? 116 CYS A CB 1 ATOM 876 S SG . CYS A 1 132 ? -24.425 21.440 9.549 1.00 6.81 ? 116 CYS A SG 1 ATOM 877 N N . ALA A 1 133 ? -23.289 17.137 7.600 1.00 8.86 ? 117 ALA A N 1 ATOM 878 C CA . ALA A 1 133 ? -22.431 16.107 7.028 1.00 7.95 ? 117 ALA A CA 1 ATOM 879 C C . ALA A 1 133 ? -22.030 16.489 5.610 1.00 7.34 ? 117 ALA A C 1 ATOM 880 O O . ALA A 1 133 ? -22.813 17.088 4.875 1.00 11.43 ? 117 ALA A O 1 ATOM 881 C CB . ALA A 1 133 ? -23.140 14.766 7.035 1.00 13.25 ? 117 ALA A CB 1 ATOM 882 N N . LYS A 1 134 ? -20.807 16.135 5.230 1.00 10.44 ? 118 LYS A N 1 ATOM 883 C CA . LYS A 1 134 ? -20.273 16.493 3.923 1.00 7.36 ? 118 LYS A CA 1 ATOM 884 C C . LYS A 1 134 ? -20.777 15.526 2.857 1.00 7.53 ? 118 LYS A C 1 ATOM 885 O O . LYS A 1 134 ? -20.513 14.325 2.919 1.00 10.71 ? 118 LYS A O 1 ATOM 886 C CB . LYS A 1 134 ? -18.745 16.484 3.967 1.00 10.42 ? 118 LYS A CB 1 ATOM 887 C CG . LYS A 1 134 ? -18.075 17.237 2.830 1.00 11.47 ? 118 LYS A CG 1 ATOM 888 C CD . LYS A 1 134 ? -16.561 17.222 2.988 1.00 17.44 ? 118 LYS A CD 1 ATOM 889 C CE . LYS A 1 134 ? -15.879 18.109 1.962 1.00 25.72 ? 118 LYS A CE 1 ATOM 890 N NZ . LYS A 1 134 ? -14.400 18.099 2.116 1.00 29.62 ? 118 LYS A NZ 1 ATOM 891 N N . PHE A 1 135 ? -21.503 16.062 1.882 1.00 12.26 ? 119 PHE A N 1 ATOM 892 C CA . PHE A 1 135 ? -22.077 15.262 0.808 1.00 9.24 ? 119 PHE A CA 1 ATOM 893 C C . PHE A 1 135 ? -21.129 15.196 -0.383 1.00 10.22 ? 119 PHE A C 1 ATOM 894 O O . PHE A 1 135 ? -20.512 16.196 -0.749 1.00 10.87 ? 119 PHE A O 1 ATOM 895 C CB . PHE A 1 135 ? -23.414 15.864 0.369 1.00 8.70 ? 119 PHE A CB 1 ATOM 896 C CG . PHE A 1 135 ? -24.105 15.087 -0.717 1.00 8.39 ? 119 PHE A CG 1 ATOM 897 C CD1 . PHE A 1 135 ? -24.920 14.013 -0.404 1.00 6.58 ? 119 PHE A CD1 1 ATOM 898 C CD2 . PHE A 1 135 ? -23.943 15.432 -2.049 1.00 9.72 ? 119 PHE A CD2 1 ATOM 899 C CE1 . PHE A 1 135 ? -25.559 13.296 -1.398 1.00 9.38 ? 119 PHE A CE1 1 ATOM 900 C CE2 . PHE A 1 135 ? -24.580 14.718 -3.048 1.00 6.53 ? 119 PHE A CE2 1 ATOM 901 C CZ . PHE A 1 135 ? -25.388 13.649 -2.721 1.00 5.50 ? 119 PHE A CZ 1 ATOM 902 N N . LYS A 1 136 ? -21.023 14.016 -0.988 1.00 14.24 ? 120 LYS A N 1 ATOM 903 C CA . LYS A 1 136 ? -20.158 13.819 -2.146 1.00 13.04 ? 120 LYS A CA 1 ATOM 904 C C . LYS A 1 136 ? -20.789 12.827 -3.114 1.00 9.50 ? 120 LYS A C 1 ATOM 905 O O . LYS A 1 136 ? -21.200 11.740 -2.712 1.00 11.69 ? 120 LYS A O 1 ATOM 906 C CB . LYS A 1 136 ? -18.794 13.282 -1.710 1.00 21.25 ? 120 LYS A CB 1 ATOM 907 C CG . LYS A 1 136 ? -17.626 13.792 -2.536 1.00 15.87 ? 120 LYS A CG 1 ATOM 908 C CD . LYS A 1 136 ? -17.533 15.310 -2.507 1.00 30.64 ? 120 LYS A CD 1 ATOM 909 C CE . LYS A 1 136 ? -17.509 15.857 -1.084 1.00 22.85 ? 120 LYS A CE 1 ATOM 910 N NZ . LYS A 1 136 ? -17.731 17.325 -1.050 1.00 25.78 ? 120 LYS A NZ 1 ATOM 911 N N . CYS A 1 137 ? -20.853 13.194 -4.389 1.00 11.82 ? 121 CYS A N 1 ATOM 912 C CA . CYS A 1 137 ? -21.382 12.297 -5.409 1.00 15.01 ? 121 CYS A CA 1 ATOM 913 C C . CYS A 1 137 ? -20.268 11.398 -5.925 1.00 11.57 ? 121 CYS A C 1 ATOM 914 O O . CYS A 1 137 ? -19.294 11.871 -6.511 1.00 9.92 ? 121 CYS A O 1 ATOM 915 C CB . CYS A 1 137 ? -22.002 13.093 -6.562 1.00 7.47 ? 121 CYS A CB 1 ATOM 916 S SG . CYS A 1 137 ? -23.026 12.112 -7.682 1.00 14.11 ? 121 CYS A SG 1 ATOM 917 N N . VAL A 1 138 ? -20.413 10.099 -5.685 1.00 9.20 ? 122 VAL A N 1 ATOM 918 C CA . VAL A 1 138 ? -19.434 9.115 -6.122 1.00 12.44 ? 122 VAL A CA 1 ATOM 919 C C . VAL A 1 138 ? -19.756 8.643 -7.532 1.00 13.59 ? 122 VAL A C 1 ATOM 920 O O . VAL A 1 138 ? -18.868 8.526 -8.376 1.00 14.54 ? 122 VAL A O 1 ATOM 921 C CB . VAL A 1 138 ? -19.419 7.900 -5.178 1.00 11.44 ? 122 VAL A CB 1 ATOM 922 C CG1 . VAL A 1 138 ? -18.486 6.823 -5.706 1.00 18.28 ? 122 VAL A CG1 1 ATOM 923 C CG2 . VAL A 1 138 ? -19.014 8.327 -3.773 1.00 16.20 ? 122 VAL A CG2 1 ATOM 924 N N . THR A 1 139 ? -21.032 8.371 -7.779 1.00 15.86 ? 123 THR A N 1 ATOM 925 C CA . THR A 1 139 ? -21.477 7.941 -9.094 1.00 8.63 ? 123 THR A CA 1 ATOM 926 C C . THR A 1 139 ? -22.599 8.848 -9.580 1.00 9.36 ? 123 THR A C 1 ATOM 927 O O . THR A 1 139 ? -23.617 9.012 -8.908 1.00 9.94 ? 123 THR A O 1 ATOM 928 C CB . THR A 1 139 ? -21.977 6.488 -9.074 1.00 10.13 ? 123 THR A CB 1 ATOM 929 O OG1 . THR A 1 139 ? -21.049 5.668 -8.353 1.00 15.33 ? 123 THR A OG1 1 ATOM 930 C CG2 . THR A 1 139 ? -22.128 5.958 -10.490 1.00 8.20 ? 123 THR A CG2 1 ATOM 931 N N . LYS A 1 140 ? -22.402 9.436 -10.752 1.00 11.37 ? 124 LYS A N 1 ATOM 932 C CA . LYS A 1 140 ? -23.379 10.346 -11.327 1.00 11.46 ? 124 LYS A CA 1 ATOM 933 C C . LYS A 1 140 ? -23.705 9.941 -12.758 1.00 11.16 ? 124 LYS A C 1 ATOM 934 O O . LYS A 1 140 ? -22.913 9.270 -13.420 1.00 8.56 ? 124 LYS A O 1 ATOM 935 C CB . LYS A 1 140 ? -22.834 11.775 -11.317 1.00 13.31 ? 124 LYS A CB 1 ATOM 936 C CG . LYS A 1 140 ? -21.382 11.860 -11.746 1.00 19.82 ? 124 LYS A CG 1 ATOM 937 C CD . LYS A 1 140 ? -20.989 13.265 -12.165 1.00 29.72 ? 124 LYS A CD 1 ATOM 938 C CE . LYS A 1 140 ? -19.534 13.313 -12.611 1.00 34.23 ? 124 LYS A CE 1 ATOM 939 N NZ . LYS A 1 140 ? -19.216 14.529 -13.410 1.00 33.23 ? 124 LYS A NZ 1 ATOM 940 N N . LEU A 1 141 ? -24.879 10.349 -13.226 1.00 9.48 ? 125 LEU A N 1 ATOM 941 C CA . LEU A 1 141 ? -25.240 10.200 -14.628 1.00 13.46 ? 125 LEU A CA 1 ATOM 942 C C . LEU A 1 141 ? -25.410 11.594 -15.217 1.00 10.08 ? 125 LEU A C 1 ATOM 943 O O . LEU A 1 141 ? -25.383 12.585 -14.488 1.00 11.43 ? 125 LEU A O 1 ATOM 944 C CB . LEU A 1 141 ? -26.522 9.376 -14.784 1.00 18.36 ? 125 LEU A CB 1 ATOM 945 C CG . LEU A 1 141 ? -27.814 9.934 -14.180 1.00 15.83 ? 125 LEU A CG 1 ATOM 946 C CD1 . LEU A 1 141 ? -28.434 11.014 -15.059 1.00 8.21 ? 125 LEU A CD1 1 ATOM 947 C CD2 . LEU A 1 141 ? -28.808 8.809 -13.953 1.00 16.79 ? 125 LEU A CD2 1 ATOM 948 N N . GLU A 1 142 ? -25.590 11.675 -16.530 1.00 13.45 ? 126 GLU A N 1 ATOM 949 C CA . GLU A 1 142 ? -25.705 12.968 -17.193 1.00 9.31 ? 126 GLU A CA 1 ATOM 950 C C . GLU A 1 142 ? -26.755 12.954 -18.297 1.00 7.57 ? 126 GLU A C 1 ATOM 951 O O . GLU A 1 142 ? -26.838 12.009 -19.080 1.00 11.51 ? 126 GLU A O 1 ATOM 952 C CB . GLU A 1 142 ? -24.353 13.391 -17.773 1.00 10.52 ? 126 GLU A CB 1 ATOM 953 C CG . GLU A 1 142 ? -23.229 13.415 -16.750 1.00 13.67 ? 126 GLU A CG 1 ATOM 954 C CD . GLU A 1 142 ? -22.063 14.287 -17.176 1.00 15.39 ? 126 GLU A CD 1 ATOM 955 O OE1 . GLU A 1 142 ? -21.281 14.707 -16.296 1.00 22.09 ? 126 GLU A OE1 1 ATOM 956 O OE2 . GLU A 1 142 ? -21.924 14.548 -18.389 1.00 14.18 ? 126 GLU A OE2 1 ATOM 957 N N . GLY A 1 143 ? -27.557 14.013 -18.346 1.00 6.68 ? 127 GLY A N 1 ATOM 958 C CA . GLY A 1 143 ? -28.547 14.186 -19.393 1.00 7.88 ? 127 GLY A CA 1 ATOM 959 C C . GLY A 1 143 ? -28.097 15.274 -20.345 1.00 4.26 ? 127 GLY A C 1 ATOM 960 O O . GLY A 1 143 ? -27.899 16.416 -19.937 1.00 6.34 ? 127 GLY A O 1 ATOM 961 N N . LYS A 1 144 ? -27.931 14.925 -21.615 1.00 10.81 ? 128 LYS A N 1 ATOM 962 C CA . LYS A 1 144 ? -27.365 15.852 -22.587 1.00 6.68 ? 128 LYS A CA 1 ATOM 963 C C . LYS A 1 144 ? -28.350 16.161 -23.709 1.00 4.58 ? 128 LYS A C 1 ATOM 964 O O . LYS A 1 144 ? -28.956 15.257 -24.283 1.00 3.93 ? 128 LYS A O 1 ATOM 965 C CB . LYS A 1 144 ? -26.078 15.269 -23.171 1.00 8.51 ? 128 LYS A CB 1 ATOM 966 C CG . LYS A 1 144 ? -25.033 14.893 -22.126 1.00 10.86 ? 128 LYS A CG 1 ATOM 967 C CD . LYS A 1 144 ? -24.136 13.772 -22.624 1.00 10.04 ? 128 LYS A CD 1 ATOM 968 C CE . LYS A 1 144 ? -24.874 12.443 -22.623 1.00 13.34 ? 128 LYS A CE 1 ATOM 969 N NZ . LYS A 1 144 ? -24.273 11.452 -23.554 1.00 19.71 ? 128 LYS A NZ 1 ATOM 970 N N . ILE A 1 145 ? -28.504 17.444 -24.019 1.00 4.30 ? 129 ILE A N 1 ATOM 971 C CA . ILE A 1 145 ? -29.410 17.869 -25.081 1.00 4.86 ? 129 ILE A CA 1 ATOM 972 C C . ILE A 1 145 ? -28.679 17.966 -26.418 1.00 5.62 ? 129 ILE A C 1 ATOM 973 O O . ILE A 1 145 ? -27.554 18.462 -26.490 1.00 6.55 ? 129 ILE A O 1 ATOM 974 C CB . ILE A 1 145 ? -30.067 19.231 -24.763 1.00 4.41 ? 129 ILE A CB 1 ATOM 975 C CG1 . ILE A 1 145 ? -29.003 20.284 -24.452 1.00 3.90 ? 129 ILE A CG1 1 ATOM 976 C CG2 . ILE A 1 145 ? -31.024 19.090 -23.589 1.00 6.53 ? 129 ILE A CG2 1 ATOM 977 C CD1 . ILE A 1 145 ? -29.497 21.699 -24.566 1.00 9.45 ? 129 ILE A CD1 1 ATOM 978 N N . VAL A 1 146 ? -29.325 17.482 -27.474 1.00 7.87 ? 130 VAL A N 1 ATOM 979 C CA . VAL A 1 146 ? -28.761 17.555 -28.816 1.00 3.12 ? 130 VAL A CA 1 ATOM 980 C C . VAL A 1 146 ? -29.272 18.793 -29.542 1.00 2.73 ? 130 VAL A C 1 ATOM 981 O O . VAL A 1 146 ? -30.476 18.964 -29.728 1.00 3.17 ? 130 VAL A O 1 ATOM 982 C CB . VAL A 1 146 ? -29.119 16.312 -29.650 1.00 3.57 ? 130 VAL A CB 1 ATOM 983 C CG1 . VAL A 1 146 ? -28.565 16.443 -31.063 1.00 4.31 ? 130 VAL A CG1 1 ATOM 984 C CG2 . VAL A 1 146 ? -28.592 15.053 -28.984 1.00 1.68 ? 130 VAL A CG2 1 ATOM 985 N N . GLN A 1 147 ? -28.344 19.651 -29.950 1.00 7.61 ? 131 GLN A N 1 ATOM 986 C CA . GLN A 1 147 ? -28.682 20.857 -30.693 1.00 5.20 ? 131 GLN A CA 1 ATOM 987 C C . GLN A 1 147 ? -28.246 20.703 -32.146 1.00 3.93 ? 131 GLN A C 1 ATOM 988 O O . GLN A 1 147 ? -27.642 19.697 -32.516 1.00 5.88 ? 131 GLN A O 1 ATOM 989 C CB . GLN A 1 147 ? -28.001 22.075 -30.063 1.00 5.69 ? 131 GLN A CB 1 ATOM 990 C CG . GLN A 1 147 ? -28.349 22.285 -28.595 1.00 2.13 ? 131 GLN A CG 1 ATOM 991 C CD . GLN A 1 147 ? -27.583 23.432 -27.968 1.00 6.92 ? 131 GLN A CD 1 ATOM 992 O OE1 . GLN A 1 147 ? -26.844 23.244 -27.001 1.00 12.46 ? 131 GLN A OE1 1 ATOM 993 N NE2 . GLN A 1 147 ? -27.763 24.632 -28.508 1.00 3.92 ? 131 GLN A NE2 1 ATOM 994 N N . TYR A 1 148 ? -28.556 21.701 -32.967 1.00 5.21 ? 132 TYR A N 1 ATOM 995 C CA . TYR A 1 148 ? -28.188 21.678 -34.378 1.00 9.85 ? 132 TYR A CA 1 ATOM 996 C C . TYR A 1 148 ? -26.687 21.487 -34.549 1.00 6.50 ? 132 TYR A C 1 ATOM 997 O O . TYR A 1 148 ? -26.238 20.725 -35.404 1.00 9.51 ? 132 TYR A O 1 ATOM 998 C CB . TYR A 1 148 ? -28.608 22.984 -35.056 1.00 13.27 ? 132 TYR A CB 1 ATOM 999 C CG . TYR A 1 148 ? -30.105 23.189 -35.162 1.00 10.84 ? 132 TYR A CG 1 ATOM 1000 C CD1 . TYR A 1 148 ? -30.956 22.126 -35.435 1.00 9.56 ? 132 TYR A CD1 1 ATOM 1001 C CD2 . TYR A 1 148 ? -30.665 24.448 -34.988 1.00 11.25 ? 132 TYR A CD2 1 ATOM 1002 C CE1 . TYR A 1 148 ? -32.323 22.313 -35.533 1.00 11.14 ? 132 TYR A CE1 1 ATOM 1003 C CE2 . TYR A 1 148 ? -32.029 24.643 -35.082 1.00 13.95 ? 132 TYR A CE2 1 ATOM 1004 C CZ . TYR A 1 148 ? -32.853 23.574 -35.355 1.00 11.53 ? 132 TYR A CZ 1 ATOM 1005 O OH . TYR A 1 148 ? -34.212 23.764 -35.451 1.00 25.41 ? 132 TYR A OH 1 ATOM 1006 N N . GLU A 1 149 ? -25.915 22.186 -33.725 1.00 6.25 ? 133 GLU A N 1 ATOM 1007 C CA . GLU A 1 149 ? -24.463 22.191 -33.846 1.00 6.71 ? 133 GLU A CA 1 ATOM 1008 C C . GLU A 1 149 ? -23.846 20.845 -33.471 1.00 6.92 ? 133 GLU A C 1 ATOM 1009 O O . GLU A 1 149 ? -22.653 20.628 -33.675 1.00 6.96 ? 133 GLU A O 1 ATOM 1010 C CB . GLU A 1 149 ? -23.872 23.296 -32.967 1.00 6.01 ? 133 GLU A CB 1 ATOM 1011 C CG . GLU A 1 149 ? -23.967 23.011 -31.471 1.00 8.88 ? 133 GLU A CG 1 ATOM 1012 C CD . GLU A 1 149 ? -24.010 24.269 -30.623 1.00 10.76 ? 133 GLU A CD 1 ATOM 1013 O OE1 . GLU A 1 149 ? -23.148 24.416 -29.732 1.00 11.99 ? 133 GLU A OE1 1 ATOM 1014 O OE2 . GLU A 1 149 ? -24.913 25.103 -30.839 1.00 12.31 ? 133 GLU A OE2 1 ATOM 1015 N N . ASN A 1 150 ? -24.660 19.937 -32.942 1.00 7.93 ? 134 ASN A N 1 ATOM 1016 C CA . ASN A 1 150 ? -24.168 18.636 -32.502 1.00 5.50 ? 134 ASN A CA 1 ATOM 1017 C C . ASN A 1 150 ? -24.386 17.541 -33.542 1.00 4.53 ? 134 ASN A C 1 ATOM 1018 O O . ASN A 1 150 ? -23.817 16.458 -33.432 1.00 8.61 ? 134 ASN A O 1 ATOM 1019 C CB . ASN A 1 150 ? -24.835 18.243 -31.181 1.00 5.45 ? 134 ASN A CB 1 ATOM 1020 C CG . ASN A 1 150 ? -24.576 19.247 -30.077 1.00 4.37 ? 134 ASN A CG 1 ATOM 1021 O OD1 . ASN A 1 150 ? -25.491 19.924 -29.607 1.00 3.71 ? 134 ASN A OD1 1 ATOM 1022 N ND2 . ASN A 1 150 ? -23.321 19.351 -29.658 1.00 3.13 ? 134 ASN A ND2 1 ATOM 1023 N N . LEU A 1 151 ? -25.192 17.829 -34.560 1.00 4.45 ? 135 LEU A N 1 ATOM 1024 C CA . LEU A 1 151 ? -25.561 16.821 -35.549 1.00 5.97 ? 135 LEU A CA 1 ATOM 1025 C C . LEU A 1 151 ? -24.681 16.915 -36.794 1.00 4.77 ? 135 LEU A C 1 ATOM 1026 O O . LEU A 1 151 ? -24.332 18.010 -37.235 1.00 7.75 ? 135 LEU A O 1 ATOM 1027 C CB . LEU A 1 151 ? -27.031 16.984 -35.939 1.00 7.38 ? 135 LEU A CB 1 ATOM 1028 C CG . LEU A 1 151 ? -27.889 15.717 -35.994 1.00 2.81 ? 135 LEU A CG 1 ATOM 1029 C CD1 . LEU A 1 151 ? -29.128 15.976 -36.832 1.00 5.27 ? 135 LEU A CD1 1 ATOM 1030 C CD2 . LEU A 1 151 ? -27.121 14.521 -36.537 1.00 3.67 ? 135 LEU A CD2 1 ATOM 1031 N N . LYS A 1 152 ? -24.327 15.762 -37.355 1.00 6.92 ? 136 LYS A N 1 ATOM 1032 C CA . LYS A 1 152 ? -23.507 15.713 -38.562 1.00 8.94 ? 136 LYS A CA 1 ATOM 1033 C C . LYS A 1 152 ? -23.834 14.488 -39.413 1.00 7.68 ? 136 LYS A C 1 ATOM 1034 O O . LYS A 1 152 ? -24.100 13.408 -38.887 1.00 11.67 ? 136 LYS A O 1 ATOM 1035 C CB . LYS A 1 152 ? -22.022 15.703 -38.193 1.00 11.27 ? 136 LYS A CB 1 ATOM 1036 C CG . LYS A 1 152 ? -21.091 15.500 -39.380 1.00 9.91 ? 136 LYS A CG 1 ATOM 1037 C CD . LYS A 1 152 ? -19.631 15.645 -38.980 1.00 11.72 ? 136 LYS A CD 1 ATOM 1038 C CE . LYS A 1 152 ? -19.155 14.475 -38.132 1.00 24.09 ? 136 LYS A CE 1 ATOM 1039 N NZ . LYS A 1 152 ? -17.702 14.569 -37.821 1.00 18.52 ? 136 LYS A NZ 1 ATOM 1040 N N . TYR A 1 153 ? -23.815 14.670 -40.731 1.00 6.55 ? 137 TYR A N 1 ATOM 1041 C CA . TYR A 1 153 ? -24.038 13.578 -41.672 1.00 6.99 ? 137 TYR A CA 1 ATOM 1042 C C . TYR A 1 153 ? -22.875 13.483 -42.652 1.00 7.48 ? 137 TYR A C 1 ATOM 1043 O O . TYR A 1 153 ? -22.315 14.499 -43.062 1.00 4.72 ? 137 TYR A O 1 ATOM 1044 C CB . TYR A 1 153 ? -25.330 13.800 -42.463 1.00 7.32 ? 137 TYR A CB 1 ATOM 1045 C CG . TYR A 1 153 ? -26.584 13.883 -41.625 1.00 7.72 ? 137 TYR A CG 1 ATOM 1046 C CD1 . TYR A 1 153 ? -26.936 15.061 -40.982 1.00 5.65 ? 137 TYR A CD1 1 ATOM 1047 C CD2 . TYR A 1 153 ? -27.429 12.788 -41.495 1.00 10.82 ? 137 TYR A CD2 1 ATOM 1048 C CE1 . TYR A 1 153 ? -28.085 15.143 -40.223 1.00 4.76 ? 137 TYR A CE1 1 ATOM 1049 C CE2 . TYR A 1 153 ? -28.581 12.861 -40.739 1.00 6.92 ? 137 TYR A CE2 1 ATOM 1050 C CZ . TYR A 1 153 ? -28.904 14.041 -40.104 1.00 4.99 ? 137 TYR A CZ 1 ATOM 1051 O OH . TYR A 1 153 ? -30.052 14.116 -39.350 1.00 12.28 ? 137 TYR A OH 1 ATOM 1052 N N . SER A 1 154 ? -22.520 12.259 -43.030 1.00 11.88 ? 138 SER A N 1 ATOM 1053 C CA . SER A 1 154 ? -21.494 12.034 -44.042 1.00 5.08 ? 138 SER A CA 1 ATOM 1054 C C . SER A 1 154 ? -22.115 11.352 -45.258 1.00 8.33 ? 138 SER A C 1 ATOM 1055 O O . SER A 1 154 ? -22.462 10.174 -45.208 1.00 9.47 ? 138 SER A O 1 ATOM 1056 C CB . SER A 1 154 ? -20.358 11.175 -43.482 1.00 4.64 ? 138 SER A CB 1 ATOM 1057 O OG . SER A 1 154 ? -19.865 11.711 -42.268 1.00 12.95 ? 138 SER A OG 1 ATOM 1058 N N . VAL A 1 155 ? -22.253 12.104 -46.346 1.00 10.93 ? 139 VAL A N 1 ATOM 1059 C CA . VAL A 1 155 ? -22.863 11.594 -47.569 1.00 6.57 ? 139 VAL A CA 1 ATOM 1060 C C . VAL A 1 155 ? -21.807 11.414 -48.650 1.00 8.90 ? 139 VAL A C 1 ATOM 1061 O O . VAL A 1 155 ? -21.070 12.347 -48.957 1.00 9.75 ? 139 VAL A O 1 ATOM 1062 C CB . VAL A 1 155 ? -23.932 12.567 -48.099 1.00 5.37 ? 139 VAL A CB 1 ATOM 1063 C CG1 . VAL A 1 155 ? -24.535 12.046 -49.395 1.00 10.77 ? 139 VAL A CG1 1 ATOM 1064 C CG2 . VAL A 1 155 ? -25.014 12.790 -47.056 1.00 4.53 ? 139 VAL A CG2 1 ATOM 1065 N N . ILE A 1 156 ? -21.735 10.219 -49.230 1.00 9.08 ? 140 ILE A N 1 ATOM 1066 C CA . ILE A 1 156 ? -20.762 9.957 -50.285 1.00 8.55 ? 140 ILE A CA 1 ATOM 1067 C C . ILE A 1 156 ? -21.402 9.965 -51.670 1.00 15.84 ? 140 ILE A C 1 ATOM 1068 O O . ILE A 1 156 ? -22.431 9.330 -51.905 1.00 12.67 ? 140 ILE A O 1 ATOM 1069 C CB . ILE A 1 156 ? -20.011 8.624 -50.069 1.00 8.35 ? 140 ILE A CB 1 ATOM 1070 C CG1 . ILE A 1 156 ? -18.871 8.498 -51.083 1.00 12.04 ? 140 ILE A CG1 1 ATOM 1071 C CG2 . ILE A 1 156 ? -20.959 7.433 -50.180 1.00 18.61 ? 140 ILE A CG2 1 ATOM 1072 C CD1 . ILE A 1 156 ? -17.845 7.433 -50.736 1.00 10.32 ? 140 ILE A CD1 1 ATOM 1073 N N . VAL A 1 157 ? -20.772 10.701 -52.580 1.00 14.13 ? 141 VAL A N 1 ATOM 1074 C CA . VAL A 1 157 ? -21.224 10.807 -53.958 1.00 12.85 ? 141 VAL A CA 1 ATOM 1075 C C . VAL A 1 157 ? -20.171 10.174 -54.857 1.00 16.33 ? 141 VAL A C 1 ATOM 1076 O O . VAL A 1 157 ? -18.997 10.536 -54.793 1.00 16.63 ? 141 VAL A O 1 ATOM 1077 C CB . VAL A 1 157 ? -21.418 12.278 -54.362 1.00 14.96 ? 141 VAL A CB 1 ATOM 1078 C CG1 . VAL A 1 157 ? -21.913 12.382 -55.798 1.00 12.67 ? 141 VAL A CG1 1 ATOM 1079 C CG2 . VAL A 1 157 ? -22.379 12.964 -53.402 1.00 7.27 ? 141 VAL A CG2 1 ATOM 1080 N N . THR A 1 158 ? -20.591 9.231 -55.694 1.00 17.42 ? 142 THR A N 1 ATOM 1081 C CA . THR A 1 158 ? -19.649 8.448 -56.485 1.00 15.29 ? 142 THR A CA 1 ATOM 1082 C C . THR A 1 158 ? -20.009 8.436 -57.966 1.00 17.12 ? 142 THR A C 1 ATOM 1083 O O . THR A 1 158 ? -21.098 8.011 -58.350 1.00 18.27 ? 142 THR A O 1 ATOM 1084 C CB . THR A 1 158 ? -19.592 6.990 -55.989 1.00 23.27 ? 142 THR A CB 1 ATOM 1085 O OG1 . THR A 1 158 ? -19.766 6.956 -54.567 1.00 27.64 ? 142 THR A OG1 1 ATOM 1086 C CG2 . THR A 1 158 ? -18.262 6.350 -56.356 1.00 22.79 ? 142 THR A CG2 1 ATOM 1087 N N . VAL A 1 159 ? -19.082 8.907 -58.794 1.00 22.13 ? 143 VAL A N 1 ATOM 1088 C CA . VAL A 1 159 ? -19.229 8.831 -60.242 1.00 24.19 ? 143 VAL A CA 1 ATOM 1089 C C . VAL A 1 159 ? -18.507 7.589 -60.751 1.00 20.26 ? 143 VAL A C 1 ATOM 1090 O O . VAL A 1 159 ? -17.304 7.431 -60.540 1.00 24.68 ? 143 VAL A O 1 ATOM 1091 C CB . VAL A 1 159 ? -18.647 10.076 -60.937 1.00 23.69 ? 143 VAL A CB 1 ATOM 1092 C CG1 . VAL A 1 159 ? -18.880 10.005 -62.439 1.00 22.50 ? 143 VAL A CG1 1 ATOM 1093 C CG2 . VAL A 1 159 ? -19.263 11.341 -60.364 1.00 18.63 ? 143 VAL A CG2 1 ATOM 1094 N N . HIS A 1 160 ? -19.246 6.713 -61.423 1.00 22.65 ? 144 HIS A N 1 ATOM 1095 C CA . HIS A 1 160 ? -18.718 5.415 -61.833 1.00 19.65 ? 144 HIS A CA 1 ATOM 1096 C C . HIS A 1 160 ? -17.855 5.483 -63.092 1.00 28.59 ? 144 HIS A C 1 ATOM 1097 O O . HIS A 1 160 ? -18.237 4.980 -64.150 1.00 26.59 ? 144 HIS A O 1 ATOM 1098 C CB . HIS A 1 160 ? -19.864 4.420 -62.048 1.00 16.02 ? 144 HIS A CB 1 ATOM 1099 C CG . HIS A 1 160 ? -20.104 3.500 -60.887 1.00 19.05 ? 144 HIS A CG 1 ATOM 1100 N ND1 . HIS A 1 160 ? -19.347 3.523 -59.737 1.00 22.46 ? 144 HIS A ND1 1 ATOM 1101 C CD2 . HIS A 1 160 ? -21.022 2.519 -60.715 1.00 25.14 ? 144 HIS A CD2 1 ATOM 1102 C CE1 . HIS A 1 160 ? -19.792 2.597 -58.901 1.00 28.18 ? 144 HIS A CE1 1 ATOM 1103 N NE2 . HIS A 1 160 ? -20.807 1.976 -59.472 1.00 39.00 ? 144 HIS A NE2 1 ATOM 1104 N N . THR A 1 161 ? -16.688 6.106 -62.970 1.00 34.50 ? 145 THR A N 1 ATOM 1105 C CA . THR A 1 161 ? -15.658 5.979 -63.989 1.00 31.78 ? 145 THR A CA 1 ATOM 1106 C C . THR A 1 161 ? -14.958 4.642 -63.775 1.00 42.24 ? 145 THR A C 1 ATOM 1107 O O . THR A 1 161 ? -14.320 4.109 -64.682 1.00 44.99 ? 145 THR A O 1 ATOM 1108 C CB . THR A 1 161 ? -14.626 7.122 -63.917 1.00 27.88 ? 145 THR A CB 1 ATOM 1109 O OG1 . THR A 1 161 ? -14.053 7.175 -62.605 1.00 40.03 ? 145 THR A OG1 1 ATOM 1110 C CG2 . THR A 1 161 ? -15.278 8.462 -64.240 1.00 27.88 ? 145 THR A CG2 1 ATOM 1111 N N . GLY A 1 162 ? -15.085 4.108 -62.562 1.00 43.67 ? 146 GLY A N 1 ATOM 1112 C CA . GLY A 1 162 ? -14.534 2.808 -62.227 1.00 50.74 ? 146 GLY A CA 1 ATOM 1113 C C . GLY A 1 162 ? -13.023 2.832 -62.138 1.00 53.21 ? 146 GLY A C 1 ATOM 1114 O O . GLY A 1 162 ? -12.351 3.387 -63.006 1.00 44.01 ? 146 GLY A O 1 ATOM 1115 N N . GLY A 1 175 ? -14.646 8.622 -55.115 1.00 20.83 ? 159 GLY A N 1 ATOM 1116 C CA . GLY A 1 175 ? -15.825 9.065 -54.395 1.00 13.11 ? 159 GLY A CA 1 ATOM 1117 C C . GLY A 1 175 ? -15.555 10.290 -53.541 1.00 12.96 ? 159 GLY A C 1 ATOM 1118 O O . GLY A 1 175 ? -14.482 10.425 -52.954 1.00 12.18 ? 159 GLY A O 1 ATOM 1119 N N . THR A 1 176 ? -16.540 11.181 -53.470 1.00 13.59 ? 160 THR A N 1 ATOM 1120 C CA . THR A 1 176 ? -16.429 12.403 -52.678 1.00 9.66 ? 160 THR A CA 1 ATOM 1121 C C . THR A 1 176 ? -17.381 12.360 -51.489 1.00 10.30 ? 160 THR A C 1 ATOM 1122 O O . THR A 1 176 ? -18.583 12.163 -51.654 1.00 14.53 ? 160 THR A O 1 ATOM 1123 C CB . THR A 1 176 ? -16.747 13.656 -53.522 1.00 11.20 ? 160 THR A CB 1 ATOM 1124 O OG1 . THR A 1 176 ? -15.738 13.832 -54.523 1.00 24.49 ? 160 THR A OG1 1 ATOM 1125 C CG2 . THR A 1 176 ? -16.805 14.899 -52.642 1.00 17.66 ? 160 THR A CG2 1 ATOM 1126 N N . ILE A 1 177 ? -16.837 12.555 -50.291 1.00 8.87 ? 161 ILE A N 1 ATOM 1127 C CA . ILE A 1 177 ? -17.635 12.514 -49.072 1.00 7.44 ? 161 ILE A CA 1 ATOM 1128 C C . ILE A 1 177 ? -18.045 13.920 -48.653 1.00 11.86 ? 161 ILE A C 1 ATOM 1129 O O . ILE A 1 177 ? -17.204 14.741 -48.287 1.00 13.98 ? 161 ILE A O 1 ATOM 1130 C CB . ILE A 1 177 ? -16.868 11.852 -47.911 1.00 9.87 ? 161 ILE A CB 1 ATOM 1131 C CG1 . ILE A 1 177 ? -16.528 10.397 -48.249 1.00 10.90 ? 161 ILE A CG1 1 ATOM 1132 C CG2 . ILE A 1 177 ? -17.693 11.904 -46.629 1.00 5.89 ? 161 ILE A CG2 1 ATOM 1133 C CD1 . ILE A 1 177 ? -15.353 10.222 -49.200 1.00 23.27 ? 161 ILE A CD1 1 ATOM 1134 N N . ALA A 1 178 ? -19.344 14.189 -48.717 1.00 11.54 ? 162 ALA A N 1 ATOM 1135 C CA . ALA A 1 178 ? -19.892 15.481 -48.329 1.00 7.57 ? 162 ALA A CA 1 ATOM 1136 C C . ALA A 1 178 ? -20.229 15.513 -46.842 1.00 7.15 ? 162 ALA A C 1 ATOM 1137 O O . ALA A 1 178 ? -20.606 14.497 -46.259 1.00 8.46 ? 162 ALA A O 1 ATOM 1138 C CB . ALA A 1 178 ? -21.132 15.776 -49.144 1.00 11.82 ? 162 ALA A CB 1 ATOM 1139 N N . THR A 1 179 ? -20.092 16.688 -46.237 1.00 10.42 ? 163 THR A N 1 ATOM 1140 C CA . THR A 1 179 ? -20.469 16.886 -44.843 1.00 7.99 ? 163 THR A CA 1 ATOM 1141 C C . THR A 1 179 ? -21.741 17.721 -44.764 1.00 7.24 ? 163 THR A C 1 ATOM 1142 O O . THR A 1 179 ? -21.768 18.866 -45.216 1.00 10.54 ? 163 THR A O 1 ATOM 1143 C CB . THR A 1 179 ? -19.359 17.598 -44.052 1.00 8.35 ? 163 THR A CB 1 ATOM 1144 O OG1 . THR A 1 179 ? -18.164 16.807 -44.077 1.00 10.37 ? 163 THR A OG1 1 ATOM 1145 C CG2 . THR A 1 179 ? -19.788 17.815 -42.608 1.00 7.30 ? 163 THR A CG2 1 ATOM 1146 N N . ILE A 1 180 ? -22.791 17.141 -44.193 1.00 5.43 ? 164 ILE A N 1 ATOM 1147 C CA . ILE A 1 180 ? -24.069 17.829 -44.063 1.00 5.64 ? 164 ILE A CA 1 ATOM 1148 C C . ILE A 1 180 ? -24.432 18.034 -42.596 1.00 5.05 ? 164 ILE A C 1 ATOM 1149 O O . ILE A 1 180 ? -24.373 17.103 -41.793 1.00 6.53 ? 164 ILE A O 1 ATOM 1150 C CB . ILE A 1 180 ? -25.204 17.040 -44.744 1.00 5.55 ? 164 ILE A CB 1 ATOM 1151 C CG1 . ILE A 1 180 ? -24.888 16.810 -46.224 1.00 6.87 ? 164 ILE A CG1 1 ATOM 1152 C CG2 . ILE A 1 180 ? -26.531 17.766 -44.578 1.00 3.24 ? 164 ILE A CG2 1 ATOM 1153 C CD1 . ILE A 1 180 ? -24.731 18.079 -47.026 1.00 6.25 ? 164 ILE A CD1 1 ATOM 1154 N N . THR A 1 181 ? -24.807 19.261 -42.257 1.00 6.89 ? 165 THR A N 1 ATOM 1155 C CA . THR A 1 181 ? -25.281 19.581 -40.916 1.00 4.56 ? 165 THR A CA 1 ATOM 1156 C C . THR A 1 181 ? -26.534 20.439 -41.021 1.00 5.21 ? 165 THR A C 1 ATOM 1157 O O . THR A 1 181 ? -26.773 21.065 -42.053 1.00 8.00 ? 165 THR A O 1 ATOM 1158 C CB . THR A 1 181 ? -24.222 20.348 -40.103 1.00 5.88 ? 165 THR A CB 1 ATOM 1159 O OG1 . THR A 1 181 ? -24.007 21.638 -40.686 1.00 8.52 ? 165 THR A OG1 1 ATOM 1160 C CG2 . THR A 1 181 ? -22.911 19.584 -40.073 1.00 8.44 ? 165 THR A CG2 1 ATOM 1161 N N . PRO A 1 182 ? -27.343 20.469 -39.953 1.00 6.10 ? 166 PRO A N 1 ATOM 1162 C CA . PRO A 1 182 ? -28.556 21.292 -39.939 1.00 6.86 ? 166 PRO A CA 1 ATOM 1163 C C . PRO A 1 182 ? -28.301 22.741 -40.347 1.00 6.95 ? 166 PRO A C 1 ATOM 1164 O O . PRO A 1 182 ? -29.040 23.281 -41.169 1.00 10.25 ? 166 PRO A O 1 ATOM 1165 C CB . PRO A 1 182 ? -29.003 21.217 -38.479 1.00 7.27 ? 166 PRO A CB 1 ATOM 1166 C CG . PRO A 1 182 ? -28.522 19.892 -38.019 1.00 3.62 ? 166 PRO A CG 1 ATOM 1167 C CD . PRO A 1 182 ? -27.216 19.658 -38.729 1.00 7.58 ? 166 PRO A CD 1 ATOM 1168 N N . GLN A 1 183 ? -27.271 23.359 -39.779 1.00 5.67 ? 167 GLN A N 1 ATOM 1169 C CA . GLN A 1 183 ? -26.965 24.753 -40.079 1.00 4.72 ? 167 GLN A CA 1 ATOM 1170 C C . GLN A 1 183 ? -26.265 24.904 -41.429 1.00 6.24 ? 167 GLN A C 1 ATOM 1171 O O . GLN A 1 183 ? -26.345 25.958 -42.062 1.00 8.59 ? 167 GLN A O 1 ATOM 1172 C CB . GLN A 1 183 ? -26.099 25.359 -38.973 1.00 8.34 ? 167 GLN A CB 1 ATOM 1173 C CG . GLN A 1 183 ? -26.709 25.267 -37.585 1.00 7.56 ? 167 GLN A CG 1 ATOM 1174 C CD . GLN A 1 183 ? -25.875 25.983 -36.544 1.00 5.76 ? 167 GLN A CD 1 ATOM 1175 O OE1 . GLN A 1 183 ? -25.937 27.205 -36.418 1.00 9.97 ? 167 GLN A OE1 1 ATOM 1176 N NE2 . GLN A 1 183 ? -25.078 25.226 -35.800 1.00 7.72 ? 167 GLN A NE2 1 ATOM 1177 N N . ALA A 1 184 ? -25.582 23.851 -41.866 1.00 12.15 ? 168 ALA A N 1 ATOM 1178 C CA . ALA A 1 184 ? -24.905 23.854 -43.160 1.00 9.90 ? 168 ALA A CA 1 ATOM 1179 C C . ALA A 1 184 ? -25.389 22.682 -44.007 1.00 6.41 ? 168 ALA A C 1 ATOM 1180 O O . ALA A 1 184 ? -24.664 21.707 -44.201 1.00 5.74 ? 168 ALA A O 1 ATOM 1181 C CB . ALA A 1 184 ? -23.403 23.784 -42.968 1.00 8.43 ? 168 ALA A CB 1 ATOM 1182 N N . PRO A 1 185 ? -26.628 22.777 -44.510 1.00 5.79 ? 169 PRO A N 1 ATOM 1183 C CA . PRO A 1 185 ? -27.279 21.712 -45.279 1.00 8.93 ? 169 PRO A CA 1 ATOM 1184 C C . PRO A 1 185 ? -26.816 21.626 -46.732 1.00 9.58 ? 169 PRO A C 1 ATOM 1185 O O . PRO A 1 185 ? -27.098 20.629 -47.397 1.00 7.74 ? 169 PRO A O 1 ATOM 1186 C CB . PRO A 1 185 ? -28.756 22.106 -45.222 1.00 9.95 ? 169 PRO A CB 1 ATOM 1187 C CG . PRO A 1 185 ? -28.738 23.585 -45.117 1.00 9.81 ? 169 PRO A CG 1 ATOM 1188 C CD . PRO A 1 185 ? -27.522 23.930 -44.304 1.00 8.82 ? 169 PRO A CD 1 ATOM 1189 N N . THR A 1 186 ? -26.123 22.651 -47.218 1.00 9.12 ? 170 THR A N 1 ATOM 1190 C CA . THR A 1 186 ? -25.686 22.677 -48.608 1.00 8.93 ? 170 THR A CA 1 ATOM 1191 C C . THR A 1 186 ? -24.242 22.200 -48.754 1.00 11.55 ? 170 THR A C 1 ATOM 1192 O O . THR A 1 186 ? -23.410 22.434 -47.876 1.00 13.52 ? 170 THR A O 1 ATOM 1193 C CB . THR A 1 186 ? -25.798 24.090 -49.201 1.00 8.54 ? 170 THR A CB 1 ATOM 1194 O OG1 . THR A 1 186 ? -27.163 24.524 -49.160 1.00 6.65 ? 170 THR A OG1 1 ATOM 1195 C CG2 . THR A 1 186 ? -25.317 24.096 -50.640 1.00 12.37 ? 170 THR A CG2 1 ATOM 1196 N N . SER A 1 187 ? -23.950 21.533 -49.867 1.00 9.86 ? 171 SER A N 1 ATOM 1197 C CA . SER A 1 187 ? -22.584 21.115 -50.179 1.00 7.75 ? 171 SER A CA 1 ATOM 1198 C C . SER A 1 187 ? -22.360 21.062 -51.686 1.00 10.26 ? 171 SER A C 1 ATOM 1199 O O . SER A 1 187 ? -22.855 20.162 -52.363 1.00 11.19 ? 171 SER A O 1 ATOM 1200 C CB . SER A 1 187 ? -22.276 19.747 -49.568 1.00 5.67 ? 171 SER A CB 1 ATOM 1201 O OG . SER A 1 187 ? -20.970 19.327 -49.928 1.00 7.36 ? 171 SER A OG 1 ATOM 1202 N N . GLU A 1 188 ? -21.609 22.029 -52.203 1.00 11.56 ? 172 GLU A N 1 ATOM 1203 C CA . GLU A 1 188 ? -21.277 22.068 -53.621 1.00 11.83 ? 172 GLU A CA 1 ATOM 1204 C C . GLU A 1 188 ? -20.078 21.170 -53.903 1.00 15.27 ? 172 GLU A C 1 ATOM 1205 O O . GLU A 1 188 ? -19.055 21.256 -53.223 1.00 15.84 ? 172 GLU A O 1 ATOM 1206 C CB . GLU A 1 188 ? -20.976 23.504 -54.054 1.00 14.58 ? 172 GLU A CB 1 ATOM 1207 C CG . GLU A 1 188 ? -20.696 23.660 -55.543 1.00 22.13 ? 172 GLU A CG 1 ATOM 1208 C CD . GLU A 1 188 ? -20.336 25.084 -55.924 1.00 33.19 ? 172 GLU A CD 1 ATOM 1209 O OE1 . GLU A 1 188 ? -20.832 26.022 -55.266 1.00 39.13 ? 172 GLU A OE1 1 ATOM 1210 O OE2 . GLU A 1 188 ? -19.559 25.263 -56.884 1.00 31.19 ? 172 GLU A OE2 1 ATOM 1211 N N . ILE A 1 189 ? -20.211 20.306 -54.904 1.00 18.14 ? 173 ILE A N 1 ATOM 1212 C CA . ILE A 1 189 ? -19.170 19.337 -55.227 1.00 15.86 ? 173 ILE A CA 1 ATOM 1213 C C . ILE A 1 189 ? -18.923 19.255 -56.730 1.00 16.07 ? 173 ILE A C 1 ATOM 1214 O O . ILE A 1 189 ? -19.861 19.222 -57.525 1.00 13.66 ? 173 ILE A O 1 ATOM 1215 C CB . ILE A 1 189 ? -19.538 17.940 -54.693 1.00 15.84 ? 173 ILE A CB 1 ATOM 1216 C CG1 . ILE A 1 189 ? -19.106 17.809 -53.232 1.00 22.50 ? 173 ILE A CG1 1 ATOM 1217 C CG2 . ILE A 1 189 ? -18.878 16.853 -55.528 1.00 18.36 ? 173 ILE A CG2 1 ATOM 1218 C CD1 . ILE A 1 189 ? -19.610 16.555 -52.549 1.00 19.21 ? 173 ILE A CD1 1 ATOM 1219 N N . GLN A 1 190 ? -17.649 19.217 -57.109 1.00 18.58 ? 174 GLN A N 1 ATOM 1220 C CA . GLN A 1 190 ? -17.263 19.125 -58.512 1.00 22.02 ? 174 GLN A CA 1 ATOM 1221 C C . GLN A 1 190 ? -17.100 17.666 -58.922 1.00 18.85 ? 174 GLN A C 1 ATOM 1222 O O . GLN A 1 190 ? -16.268 16.946 -58.370 1.00 21.59 ? 174 GLN A O 1 ATOM 1223 C CB . GLN A 1 190 ? -15.959 19.886 -58.753 1.00 22.99 ? 174 GLN A CB 1 ATOM 1224 C CG . GLN A 1 190 ? -16.087 21.393 -58.587 1.00 26.71 ? 174 GLN A CG 1 ATOM 1225 C CD . GLN A 1 190 ? -16.853 22.042 -59.722 1.00 19.82 ? 174 GLN A CD 1 ATOM 1226 O OE1 . GLN A 1 190 ? -17.006 21.460 -60.796 1.00 15.83 ? 174 GLN A OE1 1 ATOM 1227 N NE2 . GLN A 1 190 ? -17.342 23.255 -59.488 1.00 30.48 ? 174 GLN A NE2 1 ATOM 1228 N N . LEU A 1 191 ? -17.901 17.239 -59.893 1.00 16.63 ? 175 LEU A N 1 ATOM 1229 C CA . LEU A 1 191 ? -17.880 15.857 -60.354 1.00 17.69 ? 175 LEU A CA 1 ATOM 1230 C C . LEU A 1 191 ? -17.305 15.756 -61.761 1.00 18.42 ? 175 LEU A C 1 ATOM 1231 O O . LEU A 1 191 ? -17.279 16.737 -62.505 1.00 16.99 ? 175 LEU A O 1 ATOM 1232 C CB . LEU A 1 191 ? -19.295 15.280 -60.347 1.00 16.77 ? 175 LEU A CB 1 ATOM 1233 C CG . LEU A 1 191 ? -20.083 15.431 -59.046 1.00 14.81 ? 175 LEU A CG 1 ATOM 1234 C CD1 . LEU A 1 191 ? -21.517 14.962 -59.241 1.00 14.72 ? 175 LEU A CD1 1 ATOM 1235 C CD2 . LEU A 1 191 ? -19.412 14.664 -57.918 1.00 16.50 ? 175 LEU A CD2 1 ATOM 1236 N N . THR A 1 192 ? -16.848 14.562 -62.121 1.00 20.95 ? 176 THR A N 1 ATOM 1237 C CA . THR A 1 192 ? -16.349 14.309 -63.465 1.00 22.19 ? 176 THR A CA 1 ATOM 1238 C C . THR A 1 192 ? -17.528 14.113 -64.415 1.00 23.55 ? 176 THR A C 1 ATOM 1239 O O . THR A 1 192 ? -18.442 13.341 -64.125 1.00 22.44 ? 176 THR A O 1 ATOM 1240 C CB . THR A 1 192 ? -15.449 13.057 -63.507 1.00 25.43 ? 176 THR A CB 1 ATOM 1241 O OG1 . THR A 1 192 ? -14.590 13.041 -62.361 1.00 21.45 ? 176 THR A OG1 1 ATOM 1242 C CG2 . THR A 1 192 ? -14.605 13.045 -64.773 1.00 25.40 ? 176 THR A CG2 1 ATOM 1243 N N . ASP A 1 193 ? -17.515 14.833 -65.534 1.00 27.14 ? 177 ASP A N 1 ATOM 1244 C CA . ASP A 1 193 ? -18.564 14.726 -66.551 1.00 22.37 ? 177 ASP A CA 1 ATOM 1245 C C . ASP A 1 193 ? -19.860 15.440 -66.152 1.00 26.26 ? 177 ASP A C 1 ATOM 1246 O O . ASP A 1 193 ? -20.507 16.059 -66.996 1.00 21.85 ? 177 ASP A O 1 ATOM 1247 C CB . ASP A 1 193 ? -18.859 13.256 -66.889 1.00 32.39 ? 177 ASP A CB 1 ATOM 1248 C CG . ASP A 1 193 ? -18.324 12.846 -68.251 1.00 38.14 ? 177 ASP A CG 1 ATOM 1249 O OD1 . ASP A 1 193 ? -18.980 13.153 -69.270 1.00 43.26 ? 177 ASP A OD1 1 ATOM 1250 O OD2 . ASP A 1 193 ? -17.253 12.204 -68.303 1.00 42.67 ? 177 ASP A OD2 1 ATOM 1251 N N . TYR A 1 194 ? -20.236 15.362 -64.877 1.00 27.71 ? 178 TYR A N 1 ATOM 1252 C CA . TYR A 1 194 ? -21.500 15.939 -64.415 1.00 19.38 ? 178 TYR A CA 1 ATOM 1253 C C . TYR A 1 194 ? -21.381 17.423 -64.073 1.00 20.34 ? 178 TYR A C 1 ATOM 1254 O O . TYR A 1 194 ? -22.342 18.177 -64.225 1.00 25.84 ? 178 TYR A O 1 ATOM 1255 C CB . TYR A 1 194 ? -22.033 15.163 -63.206 1.00 20.38 ? 178 TYR A CB 1 ATOM 1256 C CG . TYR A 1 194 ? -22.791 13.909 -63.579 1.00 18.09 ? 178 TYR A CG 1 ATOM 1257 C CD1 . TYR A 1 194 ? -22.134 12.697 -63.728 1.00 19.65 ? 178 TYR A CD1 1 ATOM 1258 C CD2 . TYR A 1 194 ? -24.164 13.939 -63.787 1.00 17.95 ? 178 TYR A CD2 1 ATOM 1259 C CE1 . TYR A 1 194 ? -22.820 11.549 -64.073 1.00 15.16 ? 178 TYR A CE1 1 ATOM 1260 C CE2 . TYR A 1 194 ? -24.859 12.795 -64.132 1.00 11.74 ? 178 TYR A CE2 1 ATOM 1261 C CZ . TYR A 1 194 ? -24.182 11.604 -64.272 1.00 9.35 ? 178 TYR A CZ 1 ATOM 1262 O OH . TYR A 1 194 ? -24.866 10.462 -64.614 1.00 10.46 ? 178 TYR A OH 1 ATOM 1263 N N . GLY A 1 195 ? -20.207 17.837 -63.610 1.00 17.71 ? 179 GLY A N 1 ATOM 1264 C CA . GLY A 1 195 ? -19.982 19.225 -63.250 1.00 8.99 ? 179 GLY A CA 1 ATOM 1265 C C . GLY A 1 195 ? -20.298 19.484 -61.790 1.00 12.40 ? 179 GLY A C 1 ATOM 1266 O O . GLY A 1 195 ? -20.250 18.573 -60.964 1.00 14.82 ? 179 GLY A O 1 ATOM 1267 N N . ALA A 1 196 ? -20.626 20.732 -61.471 1.00 12.01 ? 180 ALA A N 1 ATOM 1268 C CA . ALA A 1 196 ? -20.950 21.113 -60.101 1.00 9.73 ? 180 ALA A CA 1 ATOM 1269 C C . ALA A 1 196 ? -22.267 20.483 -59.655 1.00 9.86 ? 180 ALA A C 1 ATOM 1270 O O . ALA A 1 196 ? -23.252 20.489 -60.395 1.00 12.01 ? 180 ALA A O 1 ATOM 1271 C CB . ALA A 1 196 ? -21.018 22.628 -59.977 1.00 11.80 ? 180 ALA A CB 1 ATOM 1272 N N . LEU A 1 197 ? -22.274 19.937 -58.443 1.00 12.57 ? 181 LEU A N 1 ATOM 1273 C CA . LEU A 1 197 ? -23.456 19.289 -57.890 1.00 9.90 ? 181 LEU A CA 1 ATOM 1274 C C . LEU A 1 197 ? -23.704 19.797 -56.475 1.00 8.55 ? 181 LEU A C 1 ATOM 1275 O O . LEU A 1 197 ? -22.869 19.619 -55.589 1.00 12.71 ? 181 LEU A O 1 ATOM 1276 C CB . LEU A 1 197 ? -23.257 17.772 -57.876 1.00 13.22 ? 181 LEU A CB 1 ATOM 1277 C CG . LEU A 1 197 ? -24.456 16.869 -57.557 1.00 10.37 ? 181 LEU A CG 1 ATOM 1278 C CD1 . LEU A 1 197 ? -25.150 17.274 -56.271 1.00 12.31 ? 181 LEU A CD1 1 ATOM 1279 C CD2 . LEU A 1 197 ? -25.445 16.858 -58.706 1.00 13.49 ? 181 LEU A CD2 1 ATOM 1280 N N . THR A 1 198 ? -24.855 20.429 -56.268 1.00 7.04 ? 182 THR A N 1 ATOM 1281 C CA . THR A 1 198 ? -25.200 20.969 -54.963 1.00 7.43 ? 182 THR A CA 1 ATOM 1282 C C . THR A 1 198 ? -26.044 19.984 -54.160 1.00 7.43 ? 182 THR A C 1 ATOM 1283 O O . THR A 1 198 ? -27.156 19.637 -54.555 1.00 11.46 ? 182 THR A O 1 ATOM 1284 C CB . THR A 1 198 ? -25.985 22.279 -55.097 1.00 8.05 ? 182 THR A CB 1 ATOM 1285 O OG1 . THR A 1 198 ? -25.234 23.216 -55.876 1.00 9.79 ? 182 THR A OG1 1 ATOM 1286 C CG2 . THR A 1 198 ? -26.262 22.870 -53.731 1.00 5.29 ? 182 THR A CG2 1 ATOM 1287 N N . LEU A 1 199 ? -25.505 19.535 -53.031 1.00 10.12 ? 183 LEU A N 1 ATOM 1288 C CA . LEU A 1 199 ? -26.251 18.693 -52.101 1.00 6.23 ? 183 LEU A CA 1 ATOM 1289 C C . LEU A 1 199 ? -26.988 19.557 -51.089 1.00 9.87 ? 183 LEU A C 1 ATOM 1290 O O . LEU A 1 199 ? -26.371 20.126 -50.190 1.00 12.65 ? 183 LEU A O 1 ATOM 1291 C CB . LEU A 1 199 ? -25.308 17.752 -51.348 1.00 6.25 ? 183 LEU A CB 1 ATOM 1292 C CG . LEU A 1 199 ? -25.025 16.366 -51.929 1.00 10.08 ? 183 LEU A CG 1 ATOM 1293 C CD1 . LEU A 1 199 ? -24.117 15.597 -50.980 1.00 8.59 ? 183 LEU A CD1 1 ATOM 1294 C CD2 . LEU A 1 199 ? -26.309 15.590 -52.178 1.00 13.30 ? 183 LEU A CD2 1 ATOM 1295 N N . ASP A 1 200 ? -28.304 19.656 -51.237 1.00 9.17 ? 184 ASP A N 1 ATOM 1296 C CA . ASP A 1 200 ? -29.121 20.413 -50.300 1.00 7.10 ? 184 ASP A CA 1 ATOM 1297 C C . ASP A 1 200 ? -29.969 19.456 -49.469 1.00 8.05 ? 184 ASP A C 1 ATOM 1298 O O . ASP A 1 200 ? -31.115 19.166 -49.815 1.00 8.44 ? 184 ASP A O 1 ATOM 1299 C CB . ASP A 1 200 ? -30.011 21.394 -51.058 1.00 12.16 ? 184 ASP A CB 1 ATOM 1300 C CG . ASP A 1 200 ? -30.621 22.448 -50.154 1.00 17.61 ? 184 ASP A CG 1 ATOM 1301 O OD1 . ASP A 1 200 ? -30.836 22.156 -48.958 1.00 21.61 ? 184 ASP A OD1 1 ATOM 1302 O OD2 . ASP A 1 200 ? -30.881 23.571 -50.639 1.00 27.24 ? 184 ASP A OD2 1 ATOM 1303 N N . CYS A 1 201 ? -29.397 18.970 -48.373 1.00 10.33 ? 185 CYS A N 1 ATOM 1304 C CA . CYS A 1 201 ? -30.021 17.914 -47.585 1.00 6.18 ? 185 CYS A CA 1 ATOM 1305 C C . CYS A 1 201 ? -30.516 18.400 -46.226 1.00 11.94 ? 185 CYS A C 1 ATOM 1306 O O . CYS A 1 201 ? -29.998 19.369 -45.671 1.00 22.48 ? 185 CYS A O 1 ATOM 1307 C CB . CYS A 1 201 ? -29.028 16.769 -47.387 1.00 6.51 ? 185 CYS A CB 1 ATOM 1308 S SG . CYS A 1 201 ? -28.476 15.994 -48.922 1.00 13.57 ? 185 CYS A SG 1 ATOM 1309 N N . SER A 1 202 ? -31.528 17.714 -45.703 1.00 10.15 ? 186 SER A N 1 ATOM 1310 C CA . SER A 1 202 ? -32.064 18.007 -44.380 1.00 5.63 ? 186 SER A CA 1 ATOM 1311 C C . SER A 1 202 ? -32.493 16.712 -43.698 1.00 11.28 ? 186 SER A C 1 ATOM 1312 O O . SER A 1 202 ? -32.830 15.737 -44.371 1.00 11.32 ? 186 SER A O 1 ATOM 1313 C CB . SER A 1 202 ? -33.264 18.947 -44.486 1.00 9.16 ? 186 SER A CB 1 ATOM 1314 O OG . SER A 1 202 ? -32.927 20.134 -45.182 1.00 21.82 ? 186 SER A OG 1 ATOM 1315 N N . PRO A 1 203 ? -32.480 16.695 -42.356 1.00 12.74 ? 187 PRO A N 1 ATOM 1316 C CA . PRO A 1 203 ? -32.926 15.509 -41.615 1.00 9.23 ? 187 PRO A CA 1 ATOM 1317 C C . PRO A 1 203 ? -34.417 15.239 -41.796 1.00 12.81 ? 187 PRO A C 1 ATOM 1318 O O . PRO A 1 203 ? -35.220 16.166 -41.678 1.00 15.53 ? 187 PRO A O 1 ATOM 1319 C CB . PRO A 1 203 ? -32.639 15.877 -40.153 1.00 16.55 ? 187 PRO A CB 1 ATOM 1320 C CG . PRO A 1 203 ? -31.656 16.998 -40.209 1.00 9.79 ? 187 PRO A CG 1 ATOM 1321 C CD . PRO A 1 203 ? -31.973 17.746 -41.459 1.00 9.84 ? 187 PRO A CD 1 ATOM 1322 N N . ARG A 1 204 ? -34.783 13.992 -42.078 1.00 13.39 ? 188 ARG A N 1 ATOM 1323 C CA . ARG A 1 204 ? -36.190 13.627 -42.182 1.00 10.72 ? 188 ARG A CA 1 ATOM 1324 C C . ARG A 1 204 ? -36.841 13.662 -40.806 1.00 10.77 ? 188 ARG A C 1 ATOM 1325 O O . ARG A 1 204 ? -36.171 13.499 -39.787 1.00 15.03 ? 188 ARG A O 1 ATOM 1326 C CB . ARG A 1 204 ? -36.358 12.235 -42.798 1.00 12.88 ? 188 ARG A CB 1 ATOM 1327 C CG . ARG A 1 204 ? -36.301 12.209 -44.321 1.00 11.75 ? 188 ARG A CG 1 ATOM 1328 C CD . ARG A 1 204 ? -37.093 11.036 -44.884 1.00 13.91 ? 188 ARG A CD 1 ATOM 1329 N NE . ARG A 1 204 ? -36.528 9.758 -44.466 1.00 16.09 ? 188 ARG A NE 1 ATOM 1330 C CZ . ARG A 1 204 ? -37.069 8.571 -44.722 1.00 27.48 ? 188 ARG A CZ 1 ATOM 1331 N NH1 . ARG A 1 204 ? -38.207 8.482 -45.399 1.00 25.06 ? 188 ARG A NH1 1 ATOM 1332 N NH2 . ARG A 1 204 ? -36.472 7.466 -44.298 1.00 22.62 ? 188 ARG A NH2 1 ATOM 1333 N N . THR A 1 205 ? -38.151 13.880 -40.783 1.00 13.89 ? 189 THR A N 1 ATOM 1334 C CA . THR A 1 205 ? -38.894 13.921 -39.531 1.00 12.53 ? 189 THR A CA 1 ATOM 1335 C C . THR A 1 205 ? -38.935 12.533 -38.897 1.00 11.70 ? 189 THR A C 1 ATOM 1336 O O . THR A 1 205 ? -39.431 11.580 -39.497 1.00 11.48 ? 189 THR A O 1 ATOM 1337 C CB . THR A 1 205 ? -40.336 14.423 -39.743 1.00 11.42 ? 189 THR A CB 1 ATOM 1338 O OG1 . THR A 1 205 ? -40.314 15.707 -40.376 1.00 17.04 ? 189 THR A OG1 1 ATOM 1339 C CG2 . THR A 1 205 ? -41.063 14.531 -38.413 1.00 14.08 ? 189 THR A CG2 1 ATOM 1340 N N . GLY A 1 206 ? -38.403 12.428 -37.683 1.00 12.65 ? 190 GLY A N 1 ATOM 1341 C CA . GLY A 1 206 ? -38.364 11.169 -36.963 1.00 6.81 ? 190 GLY A CA 1 ATOM 1342 C C . GLY A 1 206 ? -38.050 11.417 -35.503 1.00 7.41 ? 190 GLY A C 1 ATOM 1343 O O . GLY A 1 206 ? -38.936 11.755 -34.718 1.00 12.31 ? 190 GLY A O 1 ATOM 1344 N N . LEU A 1 207 ? -36.784 11.250 -35.135 1.00 10.16 ? 191 LEU A N 1 ATOM 1345 C CA . LEU A 1 207 ? -36.337 11.592 -33.790 1.00 11.53 ? 191 LEU A CA 1 ATOM 1346 C C . LEU A 1 207 ? -36.444 13.096 -33.572 1.00 11.88 ? 191 LEU A C 1 ATOM 1347 O O . LEU A 1 207 ? -36.038 13.888 -34.422 1.00 15.79 ? 191 LEU A O 1 ATOM 1348 C CB . LEU A 1 207 ? -34.891 11.143 -33.559 1.00 15.91 ? 191 LEU A CB 1 ATOM 1349 C CG . LEU A 1 207 ? -34.668 9.814 -32.830 1.00 16.18 ? 191 LEU A CG 1 ATOM 1350 C CD1 . LEU A 1 207 ? -33.178 9.556 -32.659 1.00 16.40 ? 191 LEU A CD1 1 ATOM 1351 C CD2 . LEU A 1 207 ? -35.365 9.800 -31.476 1.00 8.58 ? 191 LEU A CD2 1 ATOM 1352 N N . ASP A 1 208 ? -36.995 13.482 -32.427 1.00 12.68 ? 192 ASP A N 1 ATOM 1353 C CA . ASP A 1 208 ? -37.127 14.889 -32.077 1.00 12.39 ? 192 ASP A CA 1 ATOM 1354 C C . ASP A 1 208 ? -36.225 15.206 -30.892 1.00 8.72 ? 192 ASP A C 1 ATOM 1355 O O . ASP A 1 208 ? -36.470 14.753 -29.775 1.00 7.22 ? 192 ASP A O 1 ATOM 1356 C CB . ASP A 1 208 ? -38.582 15.223 -31.743 1.00 9.39 ? 192 ASP A CB 1 ATOM 1357 C CG . ASP A 1 208 ? -38.811 16.709 -31.555 1.00 11.52 ? 192 ASP A CG 1 ATOM 1358 O OD1 . ASP A 1 208 ? -37.823 17.441 -31.343 1.00 19.25 ? 192 ASP A OD1 1 ATOM 1359 O OD2 . ASP A 1 208 ? -39.979 17.145 -31.623 1.00 10.14 ? 192 ASP A OD2 1 ATOM 1360 N N . PHE A 1 209 ? -35.182 15.990 -31.143 1.00 9.94 ? 193 PHE A N 1 ATOM 1361 C CA . PHE A 1 209 ? -34.199 16.303 -30.113 1.00 9.76 ? 193 PHE A CA 1 ATOM 1362 C C . PHE A 1 209 ? -34.635 17.480 -29.242 1.00 6.47 ? 193 PHE A C 1 ATOM 1363 O O . PHE A 1 209 ? -33.912 17.896 -28.337 1.00 6.69 ? 193 PHE A O 1 ATOM 1364 C CB . PHE A 1 209 ? -32.833 16.571 -30.749 1.00 10.26 ? 193 PHE A CB 1 ATOM 1365 C CG . PHE A 1 209 ? -32.188 15.343 -31.327 1.00 5.39 ? 193 PHE A CG 1 ATOM 1366 C CD1 . PHE A 1 209 ? -32.142 14.163 -30.602 1.00 3.89 ? 193 PHE A CD1 1 ATOM 1367 C CD2 . PHE A 1 209 ? -31.639 15.362 -32.598 1.00 4.02 ? 193 PHE A CD2 1 ATOM 1368 C CE1 . PHE A 1 209 ? -31.554 13.031 -31.129 1.00 12.89 ? 193 PHE A CE1 1 ATOM 1369 C CE2 . PHE A 1 209 ? -31.053 14.229 -33.132 1.00 5.43 ? 193 PHE A CE2 1 ATOM 1370 C CZ . PHE A 1 209 ? -31.010 13.063 -32.396 1.00 8.46 ? 193 PHE A CZ 1 ATOM 1371 N N . ASN A 1 210 ? -35.820 18.014 -29.521 1.00 6.62 ? 194 ASN A N 1 ATOM 1372 C CA . ASN A 1 210 ? -36.442 18.985 -28.634 1.00 6.56 ? 194 ASN A CA 1 ATOM 1373 C C . ASN A 1 210 ? -37.144 18.260 -27.494 1.00 4.59 ? 194 ASN A C 1 ATOM 1374 O O . ASN A 1 210 ? -37.413 18.842 -26.444 1.00 6.31 ? 194 ASN A O 1 ATOM 1375 C CB . ASN A 1 210 ? -37.451 19.843 -29.397 1.00 13.52 ? 194 ASN A CB 1 ATOM 1376 C CG . ASN A 1 210 ? -36.809 20.657 -30.502 1.00 14.25 ? 194 ASN A CG 1 ATOM 1377 O OD1 . ASN A 1 210 ? -36.374 21.788 -30.283 1.00 14.70 ? 194 ASN A OD1 1 ATOM 1378 N ND2 . ASN A 1 210 ? -36.751 20.089 -31.701 1.00 20.66 ? 194 ASN A ND2 1 ATOM 1379 N N . GLU A 1 211 ? -37.433 16.982 -27.716 1.00 11.28 ? 195 GLU A N 1 ATOM 1380 C CA . GLU A 1 211 ? -38.171 16.173 -26.754 1.00 5.87 ? 195 GLU A CA 1 ATOM 1381 C C . GLU A 1 211 ? -37.297 15.096 -26.119 1.00 5.99 ? 195 GLU A C 1 ATOM 1382 O O . GLU A 1 211 ? -37.402 14.828 -24.923 1.00 6.15 ? 195 GLU A O 1 ATOM 1383 C CB . GLU A 1 211 ? -39.369 15.521 -27.445 1.00 7.29 ? 195 GLU A CB 1 ATOM 1384 C CG . GLU A 1 211 ? -40.116 14.511 -26.592 1.00 9.16 ? 195 GLU A CG 1 ATOM 1385 C CD . GLU A 1 211 ? -40.717 15.128 -25.345 1.00 8.75 ? 195 GLU A CD 1 ATOM 1386 O OE1 . GLU A 1 211 ? -40.709 16.371 -25.232 1.00 7.38 ? 195 GLU A OE1 1 ATOM 1387 O OE2 . GLU A 1 211 ? -41.201 14.369 -24.480 1.00 9.70 ? 195 GLU A OE2 1 ATOM 1388 N N . MET A 1 212 ? -36.440 14.476 -26.923 1.00 7.62 ? 196 MET A N 1 ATOM 1389 C CA . MET A 1 212 ? -35.608 13.381 -26.441 1.00 6.94 ? 196 MET A CA 1 ATOM 1390 C C . MET A 1 212 ? -34.259 13.887 -25.943 1.00 8.49 ? 196 MET A C 1 ATOM 1391 O O . MET A 1 212 ? -33.708 14.853 -26.470 1.00 10.57 ? 196 MET A O 1 ATOM 1392 C CB . MET A 1 212 ? -35.409 12.338 -27.541 1.00 6.14 ? 196 MET A CB 1 ATOM 1393 C CG . MET A 1 212 ? -36.713 11.768 -28.088 1.00 10.06 ? 196 MET A CG 1 ATOM 1394 S SD . MET A 1 212 ? -37.823 11.180 -26.793 1.00 3.32 ? 196 MET A SD 1 ATOM 1395 C CE . MET A 1 212 ? -36.909 9.775 -26.164 1.00 6.85 ? 196 MET A CE 1 ATOM 1396 N N . VAL A 1 213 ? -33.741 13.219 -24.918 1.00 7.96 ? 197 VAL A N 1 ATOM 1397 C CA . VAL A 1 213 ? -32.491 13.610 -24.282 1.00 8.38 ? 197 VAL A CA 1 ATOM 1398 C C . VAL A 1 213 ? -31.517 12.441 -24.265 1.00 6.48 ? 197 VAL A C 1 ATOM 1399 O O . VAL A 1 213 ? -31.923 11.280 -24.238 1.00 6.47 ? 197 VAL A O 1 ATOM 1400 C CB . VAL A 1 213 ? -32.734 14.102 -22.840 1.00 6.11 ? 197 VAL A CB 1 ATOM 1401 C CG1 . VAL A 1 213 ? -31.603 13.672 -21.915 1.00 6.72 ? 197 VAL A CG1 1 ATOM 1402 C CG2 . VAL A 1 213 ? -32.897 15.609 -22.823 1.00 7.10 ? 197 VAL A CG2 1 ATOM 1403 N N . LEU A 1 214 ? -30.229 12.757 -24.274 1.00 7.81 ? 198 LEU A N 1 ATOM 1404 C CA . LEU A 1 214 ? -29.191 11.738 -24.300 1.00 8.56 ? 198 LEU A CA 1 ATOM 1405 C C . LEU A 1 214 ? -28.713 11.454 -22.879 1.00 10.55 ? 198 LEU A C 1 ATOM 1406 O O . LEU A 1 214 ? -27.967 12.241 -22.297 1.00 10.91 ? 198 LEU A O 1 ATOM 1407 C CB . LEU A 1 214 ? -28.030 12.209 -25.177 1.00 9.13 ? 198 LEU A CB 1 ATOM 1408 C CG . LEU A 1 214 ? -27.118 11.155 -25.808 1.00 11.79 ? 198 LEU A CG 1 ATOM 1409 C CD1 . LEU A 1 214 ? -27.914 10.007 -26.417 1.00 12.92 ? 198 LEU A CD1 1 ATOM 1410 C CD2 . LEU A 1 214 ? -26.254 11.815 -26.870 1.00 9.03 ? 198 LEU A CD2 1 ATOM 1411 N N . LEU A 1 215 ? -29.154 10.333 -22.317 1.00 11.59 ? 199 LEU A N 1 ATOM 1412 C CA . LEU A 1 215 ? -28.779 9.964 -20.956 1.00 9.66 ? 199 LEU A CA 1 ATOM 1413 C C . LEU A 1 215 ? -27.550 9.063 -20.973 1.00 12.48 ? 199 LEU A C 1 ATOM 1414 O O . LEU A 1 215 ? -27.464 8.138 -21.779 1.00 15.98 ? 199 LEU A O 1 ATOM 1415 C CB . LEU A 1 215 ? -29.943 9.259 -20.253 1.00 10.34 ? 199 LEU A CB 1 ATOM 1416 C CG . LEU A 1 215 ? -29.782 9.023 -18.749 1.00 7.14 ? 199 LEU A CG 1 ATOM 1417 C CD1 . LEU A 1 215 ? -31.127 9.141 -18.051 1.00 6.39 ? 199 LEU A CD1 1 ATOM 1418 C CD2 . LEU A 1 215 ? -29.163 7.662 -18.475 1.00 13.24 ? 199 LEU A CD2 1 ATOM 1419 N N . THR A 1 216 ? -26.602 9.339 -20.082 1.00 10.59 ? 200 THR A N 1 ATOM 1420 C CA . THR A 1 216 ? -25.372 8.560 -20.008 1.00 13.83 ? 200 THR A CA 1 ATOM 1421 C C . THR A 1 216 ? -25.055 8.169 -18.570 1.00 16.57 ? 200 THR A C 1 ATOM 1422 O O . THR A 1 216 ? -24.749 9.021 -17.735 1.00 23.15 ? 200 THR A O 1 ATOM 1423 C CB . THR A 1 216 ? -24.174 9.338 -20.587 1.00 20.64 ? 200 THR A CB 1 ATOM 1424 O OG1 . THR A 1 216 ? -24.412 9.631 -21.969 1.00 20.47 ? 200 THR A OG1 1 ATOM 1425 C CG2 . THR A 1 216 ? -22.894 8.522 -20.460 1.00 21.45 ? 200 THR A CG2 1 ATOM 1426 N N . MET A 1 217 ? -25.130 6.872 -18.291 1.00 16.17 ? 201 MET A N 1 ATOM 1427 C CA . MET A 1 217 ? -24.781 6.344 -16.979 1.00 19.89 ? 201 MET A CA 1 ATOM 1428 C C . MET A 1 217 ? -23.661 5.326 -17.134 1.00 29.02 ? 201 MET A C 1 ATOM 1429 O O . MET A 1 217 ? -23.768 4.385 -17.921 1.00 32.95 ? 201 MET A O 1 ATOM 1430 C CB . MET A 1 217 ? -25.993 5.686 -16.317 1.00 19.39 ? 201 MET A CB 1 ATOM 1431 C CG . MET A 1 217 ? -25.690 5.053 -14.968 1.00 14.07 ? 201 MET A CG 1 ATOM 1432 S SD . MET A 1 217 ? -27.011 3.968 -14.407 1.00 15.13 ? 201 MET A SD 1 ATOM 1433 C CE . MET A 1 217 ? -27.977 5.114 -13.423 1.00 20.15 ? 201 MET A CE 1 ATOM 1434 N N . LYS A 1 218 ? -22.587 5.521 -16.378 1.00 28.71 ? 202 LYS A N 1 ATOM 1435 C CA . LYS A 1 218 ? -21.422 4.648 -16.457 1.00 31.01 ? 202 LYS A CA 1 ATOM 1436 C C . LYS A 1 218 ? -20.876 4.585 -17.882 1.00 28.76 ? 202 LYS A C 1 ATOM 1437 O O . LYS A 1 218 ? -20.067 5.423 -18.278 1.00 31.11 ? 202 LYS A O 1 ATOM 1438 C CB . LYS A 1 218 ? -21.764 3.244 -15.953 1.00 25.31 ? 202 LYS A CB 1 ATOM 1439 C CG . LYS A 1 218 ? -21.699 3.101 -14.442 1.00 26.29 ? 202 LYS A CG 1 ATOM 1440 C CD . LYS A 1 218 ? -20.620 2.110 -14.026 1.00 25.87 ? 202 LYS A CD 1 ATOM 1441 C CE . LYS A 1 218 ? -20.396 2.118 -12.522 1.00 20.69 ? 202 LYS A CE 1 ATOM 1442 N NZ . LYS A 1 218 ? -21.673 2.122 -11.758 1.00 16.66 ? 202 LYS A NZ 1 ATOM 1443 N N . GLU A 1 219 ? -21.324 3.595 -18.650 1.00 31.21 ? 203 GLU A N 1 ATOM 1444 C CA . GLU A 1 219 ? -20.837 3.412 -20.015 1.00 35.73 ? 203 GLU A CA 1 ATOM 1445 C C . GLU A 1 219 ? -21.973 3.381 -21.039 1.00 32.46 ? 203 GLU A C 1 ATOM 1446 O O . GLU A 1 219 ? -21.819 3.876 -22.155 1.00 30.39 ? 203 GLU A O 1 ATOM 1447 C CB . GLU A 1 219 ? -20.010 2.128 -20.114 1.00 33.29 ? 203 GLU A CB 1 ATOM 1448 C CG . GLU A 1 219 ? -19.159 2.039 -21.374 1.00 32.22 ? 203 GLU A CG 1 ATOM 1449 C CD . GLU A 1 219 ? -18.308 0.784 -21.422 1.00 37.90 ? 203 GLU A CD 1 ATOM 1450 O OE1 . GLU A 1 219 ? -18.406 0.037 -22.417 1.00 45.19 ? 203 GLU A OE1 1 ATOM 1451 O OE2 . GLU A 1 219 ? -17.534 0.552 -20.470 1.00 36.52 ? 203 GLU A OE2 1 ATOM 1452 N N . LYS A 1 220 ? -23.110 2.802 -20.661 1.00 26.05 ? 204 LYS A N 1 ATOM 1453 C CA . LYS A 1 220 ? -24.248 2.701 -21.569 1.00 19.41 ? 204 LYS A CA 1 ATOM 1454 C C . LYS A 1 220 ? -24.968 4.036 -21.698 1.00 22.21 ? 204 LYS A C 1 ATOM 1455 O O . LYS A 1 220 ? -24.835 4.912 -20.843 1.00 20.67 ? 204 LYS A O 1 ATOM 1456 C CB . LYS A 1 220 ? -25.228 1.627 -21.094 1.00 22.37 ? 204 LYS A CB 1 ATOM 1457 C CG . LYS A 1 220 ? -25.112 0.311 -21.844 1.00 33.69 ? 204 LYS A CG 1 ATOM 1458 C CD . LYS A 1 220 ? -23.784 -0.378 -21.577 1.00 35.55 ? 204 LYS A CD 1 ATOM 1459 C CE . LYS A 1 220 ? -22.866 -0.315 -22.789 1.00 41.09 ? 204 LYS A CE 1 ATOM 1460 N NZ . LYS A 1 220 ? -23.310 -1.223 -23.884 1.00 38.96 ? 204 LYS A NZ 1 ATOM 1461 N N . SER A 1 221 ? -25.738 4.178 -22.772 1.00 19.13 ? 205 SER A N 1 ATOM 1462 C CA . SER A 1 221 ? -26.457 5.416 -23.040 1.00 13.79 ? 205 SER A CA 1 ATOM 1463 C C . SER A 1 221 ? -27.833 5.114 -23.628 1.00 13.35 ? 205 SER A C 1 ATOM 1464 O O . SER A 1 221 ? -28.030 4.080 -24.265 1.00 19.05 ? 205 SER A O 1 ATOM 1465 C CB . SER A 1 221 ? -25.646 6.292 -23.997 1.00 12.44 ? 205 SER A CB 1 ATOM 1466 O OG . SER A 1 221 ? -24.296 6.370 -23.570 1.00 26.85 ? 205 SER A OG 1 ATOM 1467 N N . TRP A 1 222 ? -28.780 6.021 -23.406 1.00 10.94 ? 206 TRP A N 1 ATOM 1468 C CA . TRP A 1 222 ? -30.152 5.829 -23.863 1.00 8.10 ? 206 TRP A CA 1 ATOM 1469 C C . TRP A 1 222 ? -30.753 7.129 -24.381 1.00 14.33 ? 206 TRP A C 1 ATOM 1470 O O . TRP A 1 222 ? -30.268 8.215 -24.063 1.00 16.10 ? 206 TRP A O 1 ATOM 1471 C CB . TRP A 1 222 ? -31.020 5.315 -22.713 1.00 9.67 ? 206 TRP A CB 1 ATOM 1472 C CG . TRP A 1 222 ? -30.624 3.970 -22.183 1.00 17.82 ? 206 TRP A CG 1 ATOM 1473 C CD1 . TRP A 1 222 ? -31.132 2.760 -22.559 1.00 12.14 ? 206 TRP A CD1 1 ATOM 1474 C CD2 . TRP A 1 222 ? -29.646 3.698 -21.171 1.00 17.91 ? 206 TRP A CD2 1 ATOM 1475 N NE1 . TRP A 1 222 ? -30.529 1.752 -21.846 1.00 10.81 ? 206 TRP A NE1 1 ATOM 1476 C CE2 . TRP A 1 222 ? -29.613 2.300 -20.990 1.00 14.07 ? 206 TRP A CE2 1 ATOM 1477 C CE3 . TRP A 1 222 ? -28.795 4.498 -20.403 1.00 13.31 ? 206 TRP A CE3 1 ATOM 1478 C CZ2 . TRP A 1 222 ? -28.762 1.687 -20.073 1.00 9.63 ? 206 TRP A CZ2 1 ATOM 1479 C CZ3 . TRP A 1 222 ? -27.949 3.885 -19.495 1.00 9.83 ? 206 TRP A CZ3 1 ATOM 1480 C CH2 . TRP A 1 222 ? -27.941 2.495 -19.337 1.00 8.30 ? 206 TRP A CH2 1 ATOM 1481 N N . LEU A 1 223 ? -31.817 7.011 -25.172 1.00 9.22 ? 207 LEU A N 1 ATOM 1482 C CA . LEU A 1 223 ? -32.628 8.164 -25.548 1.00 6.93 ? 207 LEU A CA 1 ATOM 1483 C C . LEU A 1 223 ? -33.863 8.199 -24.657 1.00 6.74 ? 207 LEU A C 1 ATOM 1484 O O . LEU A 1 223 ? -34.682 7.279 -24.680 1.00 4.40 ? 207 LEU A O 1 ATOM 1485 C CB . LEU A 1 223 ? -33.047 8.097 -27.020 1.00 14.54 ? 207 LEU A CB 1 ATOM 1486 C CG . LEU A 1 223 ? -31.982 8.410 -28.076 1.00 13.40 ? 207 LEU A CG 1 ATOM 1487 C CD1 . LEU A 1 223 ? -31.291 9.731 -27.777 1.00 10.21 ? 207 LEU A CD1 1 ATOM 1488 C CD2 . LEU A 1 223 ? -30.971 7.282 -28.183 1.00 17.06 ? 207 LEU A CD2 1 ATOM 1489 N N . VAL A 1 224 ? -33.989 9.263 -23.871 1.00 6.19 ? 208 VAL A N 1 ATOM 1490 C CA . VAL A 1 224 ? -35.072 9.378 -22.903 1.00 7.25 ? 208 VAL A CA 1 ATOM 1491 C C . VAL A 1 224 ? -35.796 10.709 -23.054 1.00 7.78 ? 208 VAL A C 1 ATOM 1492 O O . VAL A 1 224 ? -35.189 11.717 -23.411 1.00 7.16 ? 208 VAL A O 1 ATOM 1493 C CB . VAL A 1 224 ? -34.538 9.272 -21.462 1.00 9.77 ? 208 VAL A CB 1 ATOM 1494 C CG1 . VAL A 1 224 ? -33.760 7.979 -21.282 1.00 8.18 ? 208 VAL A CG1 1 ATOM 1495 C CG2 . VAL A 1 224 ? -33.661 10.471 -21.126 1.00 5.96 ? 208 VAL A CG2 1 ATOM 1496 N N . HIS A 1 225 ? -37.095 10.712 -22.776 1.00 7.64 ? 209 HIS A N 1 ATOM 1497 C CA . HIS A 1 225 ? -37.877 11.941 -22.835 1.00 5.75 ? 209 HIS A CA 1 ATOM 1498 C C . HIS A 1 225 ? -37.294 12.973 -21.875 1.00 7.61 ? 209 HIS A C 1 ATOM 1499 O O . HIS A 1 225 ? -36.613 12.619 -20.913 1.00 12.85 ? 209 HIS A O 1 ATOM 1500 C CB . HIS A 1 225 ? -39.346 11.660 -22.515 1.00 6.97 ? 209 HIS A CB 1 ATOM 1501 C CG . HIS A 1 225 ? -40.070 10.935 -23.608 1.00 8.91 ? 209 HIS A CG 1 ATOM 1502 N ND1 . HIS A 1 225 ? -40.972 11.561 -24.444 1.00 7.96 ? 209 HIS A ND1 1 ATOM 1503 C CD2 . HIS A 1 225 ? -40.018 9.644 -24.009 1.00 9.09 ? 209 HIS A CD2 1 ATOM 1504 C CE1 . HIS A 1 225 ? -41.448 10.682 -25.308 1.00 7.93 ? 209 HIS A CE1 1 ATOM 1505 N NE2 . HIS A 1 225 ? -40.886 9.513 -25.068 1.00 12.51 ? 209 HIS A NE2 1 ATOM 1506 N N . LYS A 1 226 ? -37.563 14.248 -22.140 1.00 11.14 ? 210 LYS A N 1 ATOM 1507 C CA . LYS A 1 226 ? -36.904 15.333 -21.421 1.00 6.30 ? 210 LYS A CA 1 ATOM 1508 C C . LYS A 1 226 ? -37.492 15.582 -20.033 1.00 5.05 ? 210 LYS A C 1 ATOM 1509 O O . LYS A 1 226 ? -36.752 15.718 -19.060 1.00 6.80 ? 210 LYS A O 1 ATOM 1510 C CB . LYS A 1 226 ? -36.952 16.620 -22.248 1.00 5.52 ? 210 LYS A CB 1 ATOM 1511 C CG . LYS A 1 226 ? -36.352 17.828 -21.546 1.00 12.70 ? 210 LYS A CG 1 ATOM 1512 C CD . LYS A 1 226 ? -36.251 19.027 -22.475 1.00 7.56 ? 210 LYS A CD 1 ATOM 1513 C CE . LYS A 1 226 ? -35.036 18.927 -23.381 1.00 7.66 ? 210 LYS A CE 1 ATOM 1514 N NZ . LYS A 1 226 ? -34.883 20.137 -24.235 1.00 9.50 ? 210 LYS A NZ 1 ATOM 1515 N N . GLN A 1 227 ? -38.816 15.646 -19.938 1.00 6.39 ? 211 GLN A N 1 ATOM 1516 C CA . GLN A 1 227 ? -39.460 15.935 -18.660 1.00 5.52 ? 211 GLN A CA 1 ATOM 1517 C C . GLN A 1 227 ? -39.309 14.756 -17.706 1.00 9.11 ? 211 GLN A C 1 ATOM 1518 O O . GLN A 1 227 ? -39.135 14.938 -16.501 1.00 13.97 ? 211 GLN A O 1 ATOM 1519 C CB . GLN A 1 227 ? -40.941 16.271 -18.850 1.00 7.22 ? 211 GLN A CB 1 ATOM 1520 C CG . GLN A 1 227 ? -41.567 16.948 -17.639 1.00 5.38 ? 211 GLN A CG 1 ATOM 1521 C CD . GLN A 1 227 ? -40.936 18.296 -17.341 1.00 5.13 ? 211 GLN A CD 1 ATOM 1522 O OE1 . GLN A 1 227 ? -40.632 19.065 -18.252 1.00 11.76 ? 211 GLN A OE1 1 ATOM 1523 N NE2 . GLN A 1 227 ? -40.729 18.585 -16.062 1.00 5.33 ? 211 GLN A NE2 1 ATOM 1524 N N . TRP A 1 228 ? -39.388 13.547 -18.251 1.00 4.76 ? 212 TRP A N 1 ATOM 1525 C CA . TRP A 1 228 ? -39.126 12.341 -17.477 1.00 5.80 ? 212 TRP A CA 1 ATOM 1526 C C . TRP A 1 228 ? -37.812 12.497 -16.724 1.00 6.99 ? 212 TRP A C 1 ATOM 1527 O O . TRP A 1 228 ? -37.743 12.283 -15.514 1.00 9.43 ? 212 TRP A O 1 ATOM 1528 C CB . TRP A 1 228 ? -39.051 11.128 -18.404 1.00 8.65 ? 212 TRP A CB 1 ATOM 1529 C CG . TRP A 1 228 ? -38.739 9.845 -17.702 1.00 9.27 ? 212 TRP A CG 1 ATOM 1530 C CD1 . TRP A 1 228 ? -39.628 8.996 -17.114 1.00 6.51 ? 212 TRP A CD1 1 ATOM 1531 C CD2 . TRP A 1 228 ? -37.444 9.259 -17.520 1.00 6.92 ? 212 TRP A CD2 1 ATOM 1532 N NE1 . TRP A 1 228 ? -38.969 7.919 -16.574 1.00 6.32 ? 212 TRP A NE1 1 ATOM 1533 C CE2 . TRP A 1 228 ? -37.627 8.057 -16.809 1.00 6.18 ? 212 TRP A CE2 1 ATOM 1534 C CE3 . TRP A 1 228 ? -36.148 9.635 -17.887 1.00 10.63 ? 212 TRP A CE3 1 ATOM 1535 C CZ2 . TRP A 1 228 ? -36.564 7.227 -16.460 1.00 6.49 ? 212 TRP A CZ2 1 ATOM 1536 C CZ3 . TRP A 1 228 ? -35.094 8.811 -17.536 1.00 7.54 ? 212 TRP A CZ3 1 ATOM 1537 C CH2 . TRP A 1 228 ? -35.309 7.620 -16.833 1.00 6.13 ? 212 TRP A CH2 1 ATOM 1538 N N . PHE A 1 229 ? -36.772 12.876 -17.458 1.00 8.10 ? 213 PHE A N 1 ATOM 1539 C CA . PHE A 1 229 ? -35.458 13.117 -16.880 1.00 5.15 ? 213 PHE A CA 1 ATOM 1540 C C . PHE A 1 229 ? -35.499 14.222 -15.829 1.00 5.35 ? 213 PHE A C 1 ATOM 1541 O O . PHE A 1 229 ? -35.028 14.039 -14.708 1.00 7.38 ? 213 PHE A O 1 ATOM 1542 C CB . PHE A 1 229 ? -34.468 13.488 -17.985 1.00 4.74 ? 213 PHE A CB 1 ATOM 1543 C CG . PHE A 1 229 ? -33.138 13.961 -17.475 1.00 5.16 ? 213 PHE A CG 1 ATOM 1544 C CD1 . PHE A 1 229 ? -32.189 13.057 -17.031 1.00 2.87 ? 213 PHE A CD1 1 ATOM 1545 C CD2 . PHE A 1 229 ? -32.835 15.311 -17.449 1.00 4.52 ? 213 PHE A CD2 1 ATOM 1546 C CE1 . PHE A 1 229 ? -30.964 13.491 -16.564 1.00 3.12 ? 213 PHE A CE1 1 ATOM 1547 C CE2 . PHE A 1 229 ? -31.612 15.752 -16.984 1.00 3.57 ? 213 PHE A CE2 1 ATOM 1548 C CZ . PHE A 1 229 ? -30.675 14.841 -16.541 1.00 5.98 ? 213 PHE A CZ 1 ATOM 1549 N N . LEU A 1 230 ? -36.067 15.367 -16.196 1.00 8.40 ? 214 LEU A N 1 ATOM 1550 C CA . LEU A 1 230 ? -36.095 16.527 -15.311 1.00 5.15 ? 214 LEU A CA 1 ATOM 1551 C C . LEU A 1 230 ? -36.843 16.256 -14.006 1.00 5.16 ? 214 LEU A C 1 ATOM 1552 O O . LEU A 1 230 ? -36.562 16.882 -12.984 1.00 7.21 ? 214 LEU A O 1 ATOM 1553 C CB . LEU A 1 230 ? -36.725 17.725 -16.028 1.00 3.44 ? 214 LEU A CB 1 ATOM 1554 C CG . LEU A 1 230 ? -35.917 18.343 -17.172 1.00 3.31 ? 214 LEU A CG 1 ATOM 1555 C CD1 . LEU A 1 230 ? -36.688 19.495 -17.797 1.00 5.39 ? 214 LEU A CD1 1 ATOM 1556 C CD2 . LEU A 1 230 ? -34.557 18.816 -16.687 1.00 4.56 ? 214 LEU A CD2 1 ATOM 1557 N N . ASP A 1 231 ? -37.790 15.323 -14.039 1.00 5.86 ? 215 ASP A N 1 ATOM 1558 C CA . ASP A 1 231 ? -38.599 15.021 -12.862 1.00 7.26 ? 215 ASP A CA 1 ATOM 1559 C C . ASP A 1 231 ? -38.012 13.885 -12.026 1.00 5.29 ? 215 ASP A C 1 ATOM 1560 O O . ASP A 1 231 ? -38.553 13.540 -10.977 1.00 5.61 ? 215 ASP A O 1 ATOM 1561 C CB . ASP A 1 231 ? -40.032 14.674 -13.271 1.00 8.04 ? 215 ASP A CB 1 ATOM 1562 C CG . ASP A 1 231 ? -40.805 15.881 -13.763 1.00 7.23 ? 215 ASP A CG 1 ATOM 1563 O OD1 . ASP A 1 231 ? -40.383 17.020 -13.471 1.00 9.43 ? 215 ASP A OD1 1 ATOM 1564 O OD2 . ASP A 1 231 ? -41.840 15.692 -14.435 1.00 10.11 ? 215 ASP A OD2 1 ATOM 1565 N N . LEU A 1 232 ? -36.910 13.305 -12.490 1.00 8.22 ? 216 LEU A N 1 ATOM 1566 C CA . LEU A 1 232 ? -36.238 12.248 -11.742 1.00 6.33 ? 216 LEU A CA 1 ATOM 1567 C C . LEU A 1 232 ? -35.947 12.704 -10.317 1.00 8.19 ? 216 LEU A C 1 ATOM 1568 O O . LEU A 1 232 ? -35.303 13.733 -10.112 1.00 18.18 ? 216 LEU A O 1 ATOM 1569 C CB . LEU A 1 232 ? -34.931 11.848 -12.428 1.00 6.15 ? 216 LEU A CB 1 ATOM 1570 C CG . LEU A 1 232 ? -35.049 10.943 -13.655 1.00 7.02 ? 216 LEU A CG 1 ATOM 1571 C CD1 . LEU A 1 232 ? -33.691 10.768 -14.317 1.00 5.12 ? 216 LEU A CD1 1 ATOM 1572 C CD2 . LEU A 1 232 ? -35.632 9.591 -13.275 1.00 3.65 ? 216 LEU A CD2 1 ATOM 1573 N N . PRO A 1 233 ? -36.423 11.939 -9.323 1.00 10.04 ? 217 PRO A N 1 ATOM 1574 C CA . PRO A 1 233 ? -36.188 12.287 -7.919 1.00 9.42 ? 217 PRO A CA 1 ATOM 1575 C C . PRO A 1 233 ? -34.800 11.866 -7.433 1.00 10.32 ? 217 PRO A C 1 ATOM 1576 O O . PRO A 1 233 ? -34.680 11.013 -6.553 1.00 12.44 ? 217 PRO A O 1 ATOM 1577 C CB . PRO A 1 233 ? -37.282 11.509 -7.186 1.00 10.09 ? 217 PRO A CB 1 ATOM 1578 C CG . PRO A 1 233 ? -37.507 10.310 -8.032 1.00 6.53 ? 217 PRO A CG 1 ATOM 1579 C CD . PRO A 1 233 ? -37.276 10.745 -9.457 1.00 6.31 ? 217 PRO A CD 1 ATOM 1580 N N . LEU A 1 234 ? -33.765 12.462 -8.017 1.00 9.22 ? 218 LEU A N 1 ATOM 1581 C CA . LEU A 1 234 ? -32.392 12.240 -7.581 1.00 6.18 ? 218 LEU A CA 1 ATOM 1582 C C . LEU A 1 234 ? -31.726 13.586 -7.333 1.00 7.30 ? 218 LEU A C 1 ATOM 1583 O O . LEU A 1 234 ? -32.125 14.592 -7.921 1.00 10.09 ? 218 LEU A O 1 ATOM 1584 C CB . LEU A 1 234 ? -31.606 11.479 -8.650 1.00 7.76 ? 218 LEU A CB 1 ATOM 1585 C CG . LEU A 1 234 ? -31.952 10.007 -8.874 1.00 8.88 ? 218 LEU A CG 1 ATOM 1586 C CD1 . LEU A 1 234 ? -31.339 9.518 -10.178 1.00 8.67 ? 218 LEU A CD1 1 ATOM 1587 C CD2 . LEU A 1 234 ? -31.471 9.159 -7.709 1.00 6.10 ? 218 LEU A CD2 1 ATOM 1588 N N . PRO A 1 235 ? -30.710 13.616 -6.456 1.00 10.57 ? 219 PRO A N 1 ATOM 1589 C CA . PRO A 1 235 ? -29.944 14.857 -6.301 1.00 6.04 ? 219 PRO A CA 1 ATOM 1590 C C . PRO A 1 235 ? -29.389 15.307 -7.648 1.00 6.89 ? 219 PRO A C 1 ATOM 1591 O O . PRO A 1 235 ? -28.929 14.467 -8.419 1.00 7.04 ? 219 PRO A O 1 ATOM 1592 C CB . PRO A 1 235 ? -28.810 14.454 -5.356 1.00 5.91 ? 219 PRO A CB 1 ATOM 1593 C CG . PRO A 1 235 ? -29.349 13.294 -4.589 1.00 6.40 ? 219 PRO A CG 1 ATOM 1594 C CD . PRO A 1 235 ? -30.246 12.558 -5.541 1.00 6.12 ? 219 PRO A CD 1 ATOM 1595 N N . TRP A 1 236 ? -29.439 16.604 -7.932 1.00 5.76 ? 220 TRP A N 1 ATOM 1596 C CA . TRP A 1 236 ? -29.040 17.100 -9.244 1.00 6.32 ? 220 TRP A CA 1 ATOM 1597 C C . TRP A 1 236 ? -28.231 18.389 -9.158 1.00 9.63 ? 220 TRP A C 1 ATOM 1598 O O . TRP A 1 236 ? -28.295 19.114 -8.166 1.00 11.00 ? 220 TRP A O 1 ATOM 1599 C CB . TRP A 1 236 ? -30.278 17.335 -10.109 1.00 7.04 ? 220 TRP A CB 1 ATOM 1600 C CG . TRP A 1 236 ? -31.143 18.452 -9.625 1.00 9.08 ? 220 TRP A CG 1 ATOM 1601 C CD1 . TRP A 1 236 ? -32.180 18.361 -8.744 1.00 7.64 ? 220 TRP A CD1 1 ATOM 1602 C CD2 . TRP A 1 236 ? -31.051 19.832 -9.997 1.00 6.30 ? 220 TRP A CD2 1 ATOM 1603 N NE1 . TRP A 1 236 ? -32.739 19.600 -8.543 1.00 6.41 ? 220 TRP A NE1 1 ATOM 1604 C CE2 . TRP A 1 236 ? -32.065 20.520 -9.301 1.00 6.23 ? 220 TRP A CE2 1 ATOM 1605 C CE3 . TRP A 1 236 ? -30.209 20.553 -10.850 1.00 8.18 ? 220 TRP A CE3 1 ATOM 1606 C CZ2 . TRP A 1 236 ? -32.258 21.893 -9.431 1.00 7.18 ? 220 TRP A CZ2 1 ATOM 1607 C CZ3 . TRP A 1 236 ? -30.404 21.915 -10.978 1.00 4.18 ? 220 TRP A CZ3 1 ATOM 1608 C CH2 . TRP A 1 236 ? -31.419 22.571 -10.272 1.00 4.31 ? 220 TRP A CH2 1 ATOM 1609 N N . THR A 1 237 ? -27.469 18.664 -10.212 1.00 10.58 ? 221 THR A N 1 ATOM 1610 C CA . THR A 1 237 ? -26.717 19.907 -10.317 1.00 9.90 ? 221 THR A CA 1 ATOM 1611 C C . THR A 1 237 ? -26.712 20.356 -11.774 1.00 7.43 ? 221 THR A C 1 ATOM 1612 O O . THR A 1 237 ? -26.583 19.540 -12.687 1.00 6.71 ? 221 THR A O 1 ATOM 1613 C CB . THR A 1 237 ? -25.269 19.747 -9.808 1.00 8.04 ? 221 THR A CB 1 ATOM 1614 O OG1 . THR A 1 237 ? -24.622 21.024 -9.777 1.00 19.96 ? 221 THR A OG1 1 ATOM 1615 C CG2 . THR A 1 237 ? -24.484 18.808 -10.702 1.00 11.40 ? 221 THR A CG2 1 ATOM 1616 N N . SER A 1 238 ? -26.866 21.658 -11.986 1.00 6.46 ? 222 SER A N 1 ATOM 1617 C CA . SER A 1 238 ? -26.944 22.210 -13.331 1.00 6.09 ? 222 SER A CA 1 ATOM 1618 C C . SER A 1 238 ? -25.766 21.762 -14.186 1.00 9.79 ? 222 SER A C 1 ATOM 1619 O O . SER A 1 238 ? -24.720 21.376 -13.666 1.00 10.88 ? 222 SER A O 1 ATOM 1620 C CB . SER A 1 238 ? -26.984 23.738 -13.273 1.00 6.72 ? 222 SER A CB 1 ATOM 1621 O OG . SER A 1 238 ? -27.157 24.293 -14.565 1.00 10.44 ? 222 SER A OG 1 ATOM 1622 N N . GLY A 1 239 ? -25.951 21.812 -15.500 1.00 7.74 ? 223 GLY A N 1 ATOM 1623 C CA . GLY A 1 239 ? -24.887 21.501 -16.434 1.00 6.69 ? 223 GLY A CA 1 ATOM 1624 C C . GLY A 1 239 ? -24.008 22.709 -16.691 1.00 8.68 ? 223 GLY A C 1 ATOM 1625 O O . GLY A 1 239 ? -22.979 22.612 -17.360 1.00 9.36 ? 223 GLY A O 1 ATOM 1626 N N . ALA A 1 240 ? -24.418 23.853 -16.153 1.00 11.80 ? 224 ALA A N 1 ATOM 1627 C CA . ALA A 1 240 ? -23.676 25.097 -16.317 1.00 7.31 ? 224 ALA A CA 1 ATOM 1628 C C . ALA A 1 240 ? -22.230 24.937 -15.865 1.00 8.58 ? 224 ALA A C 1 ATOM 1629 O O . ALA A 1 240 ? -21.912 24.070 -15.051 1.00 10.41 ? 224 ALA A O 1 ATOM 1630 C CB . ALA A 1 240 ? -24.350 26.207 -15.535 1.00 7.84 ? 224 ALA A CB 1 ATOM 1631 N N . SER A 1 241 ? -21.357 25.783 -16.402 1.00 19.62 ? 225 SER A N 1 ATOM 1632 C CA . SER A 1 241 ? -19.939 25.741 -16.068 1.00 11.37 ? 225 SER A CA 1 ATOM 1633 C C . SER A 1 241 ? -19.691 26.179 -14.631 1.00 15.91 ? 225 SER A C 1 ATOM 1634 O O . SER A 1 241 ? -20.158 27.233 -14.203 1.00 14.46 ? 225 SER A O 1 ATOM 1635 C CB . SER A 1 241 ? -19.141 26.629 -17.023 1.00 13.15 ? 225 SER A CB 1 ATOM 1636 O OG . SER A 1 241 ? -18.500 25.855 -18.021 1.00 20.46 ? 225 SER A OG 1 ATOM 1637 N N . THR A 1 242 ? -18.946 25.365 -13.893 1.00 21.96 ? 226 THR A N 1 ATOM 1638 C CA . THR A 1 242 ? -18.636 25.671 -12.506 1.00 18.64 ? 226 THR A CA 1 ATOM 1639 C C . THR A 1 242 ? -17.342 25.004 -12.084 1.00 19.70 ? 226 THR A C 1 ATOM 1640 O O . THR A 1 242 ? -16.928 23.999 -12.662 1.00 26.75 ? 226 THR A O 1 ATOM 1641 C CB . THR A 1 242 ? -19.747 25.190 -11.558 1.00 24.27 ? 226 THR A CB 1 ATOM 1642 O OG1 . THR A 1 242 ? -19.463 25.633 -10.225 1.00 32.73 ? 226 THR A OG1 1 ATOM 1643 C CG2 . THR A 1 242 ? -19.848 23.670 -11.576 1.00 14.90 ? 226 THR A CG2 1 ATOM 1644 N N . SER A 1 243 ? -16.707 25.574 -11.069 1.00 21.42 ? 227 SER A N 1 ATOM 1645 C CA . SER A 1 243 ? -15.538 24.959 -10.461 1.00 26.39 ? 227 SER A CA 1 ATOM 1646 C C . SER A 1 243 ? -15.940 24.212 -9.200 1.00 27.38 ? 227 SER A C 1 ATOM 1647 O O . SER A 1 243 ? -15.242 23.299 -8.760 1.00 21.43 ? 227 SER A O 1 ATOM 1648 C CB . SER A 1 243 ? -14.496 26.016 -10.110 1.00 28.35 ? 227 SER A CB 1 ATOM 1649 O OG . SER A 1 243 ? -15.050 27.025 -9.285 1.00 31.46 ? 227 SER A OG 1 ATOM 1650 N N . GLN A 1 244 ? -17.065 24.613 -8.618 1.00 26.10 ? 228 GLN A N 1 ATOM 1651 C CA . GLN A 1 244 ? -17.544 24.014 -7.384 1.00 22.10 ? 228 GLN A CA 1 ATOM 1652 C C . GLN A 1 244 ? -18.836 23.251 -7.640 1.00 26.12 ? 228 GLN A C 1 ATOM 1653 O O . GLN A 1 244 ? -19.906 23.844 -7.772 1.00 31.27 ? 228 GLN A O 1 ATOM 1654 C CB . GLN A 1 244 ? -17.764 25.097 -6.330 1.00 30.62 ? 228 GLN A CB 1 ATOM 1655 C CG . GLN A 1 244 ? -17.268 24.717 -4.947 1.00 40.38 ? 228 GLN A CG 1 ATOM 1656 C CD . GLN A 1 244 ? -16.760 25.908 -4.160 1.00 50.00 ? 228 GLN A CD 1 ATOM 1657 O OE1 . GLN A 1 244 ? -17.108 27.055 -4.446 1.00 50.12 ? 228 GLN A OE1 1 ATOM 1658 N NE2 . GLN A 1 244 ? -15.922 25.641 -3.165 1.00 41.55 ? 228 GLN A NE2 1 ATOM 1659 N N . GLU A 1 245 ? -18.725 21.929 -7.720 1.00 20.37 ? 229 GLU A N 1 ATOM 1660 C CA . GLU A 1 245 ? -19.881 21.072 -7.944 1.00 18.67 ? 229 GLU A CA 1 ATOM 1661 C C . GLU A 1 245 ? -20.822 21.134 -6.743 1.00 24.69 ? 229 GLU A C 1 ATOM 1662 O O . GLU A 1 245 ? -20.497 20.639 -5.663 1.00 26.85 ? 229 GLU A O 1 ATOM 1663 C CB . GLU A 1 245 ? -19.423 19.634 -8.192 1.00 22.39 ? 229 GLU A CB 1 ATOM 1664 C CG . GLU A 1 245 ? -20.533 18.686 -8.608 1.00 13.17 ? 229 GLU A CG 1 ATOM 1665 C CD . GLU A 1 245 ? -20.001 17.366 -9.134 1.00 19.21 ? 229 GLU A CD 1 ATOM 1666 O OE1 . GLU A 1 245 ? -20.317 17.015 -10.291 1.00 22.66 ? 229 GLU A OE1 1 ATOM 1667 O OE2 . GLU A 1 245 ? -19.267 16.680 -8.391 1.00 21.32 ? 229 GLU A OE2 1 ATOM 1668 N N . THR A 1 246 ? -21.987 21.747 -6.940 1.00 26.66 ? 230 THR A N 1 ATOM 1669 C CA . THR A 1 246 ? -22.952 21.948 -5.864 1.00 25.17 ? 230 THR A CA 1 ATOM 1670 C C . THR A 1 246 ? -24.273 21.261 -6.194 1.00 20.28 ? 230 THR A C 1 ATOM 1671 O O . THR A 1 246 ? -24.867 21.504 -7.244 1.00 14.41 ? 230 THR A O 1 ATOM 1672 C CB . THR A 1 246 ? -23.196 23.451 -5.596 1.00 22.49 ? 230 THR A CB 1 ATOM 1673 O OG1 . THR A 1 246 ? -24.432 23.621 -4.892 1.00 25.70 ? 230 THR A OG1 1 ATOM 1674 C CG2 . THR A 1 246 ? -23.248 24.233 -6.900 1.00 29.65 ? 230 THR A CG2 1 ATOM 1675 N N . TRP A 1 247 ? -24.730 20.408 -5.283 1.00 15.41 ? 231 TRP A N 1 ATOM 1676 C CA . TRP A 1 247 ? -25.898 19.571 -5.527 1.00 10.41 ? 231 TRP A CA 1 ATOM 1677 C C . TRP A 1 247 ? -27.168 20.136 -4.902 1.00 12.32 ? 231 TRP A C 1 ATOM 1678 O O . TRP A 1 247 ? -27.117 20.937 -3.969 1.00 16.65 ? 231 TRP A O 1 ATOM 1679 C CB . TRP A 1 247 ? -25.650 18.158 -4.995 1.00 8.79 ? 231 TRP A CB 1 ATOM 1680 C CG . TRP A 1 247 ? -24.587 17.427 -5.746 1.00 12.06 ? 231 TRP A CG 1 ATOM 1681 C CD1 . TRP A 1 247 ? -23.259 17.365 -5.439 1.00 12.56 ? 231 TRP A CD1 1 ATOM 1682 C CD2 . TRP A 1 247 ? -24.759 16.658 -6.941 1.00 7.69 ? 231 TRP A CD2 1 ATOM 1683 N NE1 . TRP A 1 247 ? -22.594 16.602 -6.369 1.00 8.46 ? 231 TRP A NE1 1 ATOM 1684 C CE2 . TRP A 1 247 ? -23.493 16.157 -7.302 1.00 10.94 ? 231 TRP A CE2 1 ATOM 1685 C CE3 . TRP A 1 247 ? -25.862 16.344 -7.740 1.00 8.08 ? 231 TRP A CE3 1 ATOM 1686 C CZ2 . TRP A 1 247 ? -23.301 15.356 -8.425 1.00 12.62 ? 231 TRP A CZ2 1 ATOM 1687 C CZ3 . TRP A 1 247 ? -25.669 15.550 -8.854 1.00 10.05 ? 231 TRP A CZ3 1 ATOM 1688 C CH2 . TRP A 1 247 ? -24.399 15.066 -9.187 1.00 11.14 ? 231 TRP A CH2 1 ATOM 1689 N N . ASN A 1 248 ? -28.306 19.708 -5.438 1.00 12.64 ? 232 ASN A N 1 ATOM 1690 C CA . ASN A 1 248 ? -29.610 20.086 -4.915 1.00 5.05 ? 232 ASN A CA 1 ATOM 1691 C C . ASN A 1 248 ? -30.413 18.833 -4.598 1.00 6.31 ? 232 ASN A C 1 ATOM 1692 O O . ASN A 1 248 ? -30.299 17.828 -5.296 1.00 11.68 ? 232 ASN A O 1 ATOM 1693 C CB . ASN A 1 248 ? -30.365 20.939 -5.934 1.00 8.42 ? 232 ASN A CB 1 ATOM 1694 C CG . ASN A 1 248 ? -29.512 22.052 -6.509 1.00 11.34 ? 232 ASN A CG 1 ATOM 1695 O OD1 . ASN A 1 248 ? -29.267 23.065 -5.854 1.00 17.42 ? 232 ASN A OD1 1 ATOM 1696 N ND2 . ASN A 1 248 ? -29.057 21.871 -7.744 1.00 8.66 ? 232 ASN A ND2 1 ATOM 1697 N N . ARG A 1 249 ? -31.215 18.897 -3.540 1.00 9.05 ? 233 ARG A N 1 ATOM 1698 C CA . ARG A 1 249 ? -32.037 17.768 -3.114 1.00 8.58 ? 233 ARG A CA 1 ATOM 1699 C C . ARG A 1 249 ? -31.184 16.624 -2.570 1.00 10.09 ? 233 ARG A C 1 ATOM 1700 O O . ARG A 1 249 ? -31.458 15.453 -2.834 1.00 13.86 ? 233 ARG A O 1 ATOM 1701 C CB . ARG A 1 249 ? -32.907 17.258 -4.267 1.00 10.28 ? 233 ARG A CB 1 ATOM 1702 C CG . ARG A 1 249 ? -33.811 18.310 -4.886 1.00 13.31 ? 233 ARG A CG 1 ATOM 1703 C CD . ARG A 1 249 ? -34.772 18.888 -3.862 1.00 19.19 ? 233 ARG A CD 1 ATOM 1704 N NE . ARG A 1 249 ? -35.471 17.847 -3.112 1.00 23.86 ? 233 ARG A NE 1 ATOM 1705 C CZ . ARG A 1 249 ? -36.518 17.162 -3.565 1.00 26.04 ? 233 ARG A CZ 1 ATOM 1706 N NH1 . ARG A 1 249 ? -37.001 17.389 -4.779 1.00 23.28 ? 233 ARG A NH1 1 ATOM 1707 N NH2 . ARG A 1 249 ? -37.081 16.238 -2.801 1.00 27.04 ? 233 ARG A NH2 1 ATOM 1708 N N . GLN A 1 250 ? -30.155 16.967 -1.803 1.00 13.27 ? 234 GLN A N 1 ATOM 1709 C CA . GLN A 1 250 ? -29.271 15.968 -1.210 1.00 13.72 ? 234 GLN A CA 1 ATOM 1710 C C . GLN A 1 250 ? -30.037 15.023 -0.291 1.00 11.10 ? 234 GLN A C 1 ATOM 1711 O O . GLN A 1 250 ? -29.706 13.843 -0.184 1.00 11.49 ? 234 GLN A O 1 ATOM 1712 C CB . GLN A 1 250 ? -28.152 16.655 -0.425 1.00 8.77 ? 234 GLN A CB 1 ATOM 1713 C CG . GLN A 1 250 ? -27.156 17.410 -1.297 1.00 11.56 ? 234 GLN A CG 1 ATOM 1714 C CD . GLN A 1 250 ? -26.857 18.804 -0.777 1.00 17.74 ? 234 GLN A CD 1 ATOM 1715 O OE1 . GLN A 1 250 ? -27.557 19.762 -1.104 1.00 21.94 ? 234 GLN A OE1 1 ATOM 1716 N NE2 . GLN A 1 250 ? -25.811 18.925 0.032 1.00 9.30 ? 234 GLN A NE2 1 ATOM 1717 N N . ASP A 1 251 ? -31.060 15.552 0.371 1.00 11.73 ? 235 ASP A N 1 ATOM 1718 C CA . ASP A 1 251 ? -31.905 14.754 1.256 1.00 14.11 ? 235 ASP A CA 1 ATOM 1719 C C . ASP A 1 251 ? -32.350 13.443 0.613 1.00 17.50 ? 235 ASP A C 1 ATOM 1720 O O . ASP A 1 251 ? -32.588 12.454 1.307 1.00 25.06 ? 235 ASP A O 1 ATOM 1721 C CB . ASP A 1 251 ? -33.139 15.556 1.683 1.00 21.38 ? 235 ASP A CB 1 ATOM 1722 C CG . ASP A 1 251 ? -33.752 16.341 0.538 1.00 20.05 ? 235 ASP A CG 1 ATOM 1723 O OD1 . ASP A 1 251 ? -32.989 16.900 -0.278 1.00 21.94 ? 235 ASP A OD1 1 ATOM 1724 O OD2 . ASP A 1 251 ? -34.998 16.401 0.452 1.00 17.72 ? 235 ASP A OD2 1 ATOM 1725 N N . LEU A 1 252 ? -32.462 13.437 -0.712 1.00 21.41 ? 236 LEU A N 1 ATOM 1726 C CA . LEU A 1 252 ? -32.949 12.266 -1.436 1.00 15.14 ? 236 LEU A CA 1 ATOM 1727 C C . LEU A 1 252 ? -32.048 11.041 -1.268 1.00 16.33 ? 236 LEU A C 1 ATOM 1728 O O . LEU A 1 252 ? -32.486 9.912 -1.492 1.00 23.09 ? 236 LEU A O 1 ATOM 1729 C CB . LEU A 1 252 ? -33.107 12.598 -2.922 1.00 11.37 ? 236 LEU A CB 1 ATOM 1730 C CG . LEU A 1 252 ? -34.139 13.683 -3.239 1.00 17.58 ? 236 LEU A CG 1 ATOM 1731 C CD1 . LEU A 1 252 ? -34.144 14.003 -4.726 1.00 17.66 ? 236 LEU A CD1 1 ATOM 1732 C CD2 . LEU A 1 252 ? -35.526 13.255 -2.781 1.00 17.44 ? 236 LEU A CD2 1 ATOM 1733 N N . LEU A 1 253 ? -30.795 11.262 -0.877 1.00 15.85 ? 237 LEU A N 1 ATOM 1734 C CA . LEU A 1 253 ? -29.856 10.161 -0.669 1.00 11.56 ? 237 LEU A CA 1 ATOM 1735 C C . LEU A 1 253 ? -29.273 10.138 0.743 1.00 10.94 ? 237 LEU A C 1 ATOM 1736 O O . LEU A 1 253 ? -28.488 9.252 1.073 1.00 17.16 ? 237 LEU A O 1 ATOM 1737 C CB . LEU A 1 253 ? -28.709 10.237 -1.680 1.00 12.16 ? 237 LEU A CB 1 ATOM 1738 C CG . LEU A 1 253 ? -29.044 9.982 -3.151 1.00 11.31 ? 237 LEU A CG 1 ATOM 1739 C CD1 . LEU A 1 253 ? -27.770 10.007 -3.981 1.00 6.94 ? 237 LEU A CD1 1 ATOM 1740 C CD2 . LEU A 1 253 ? -29.771 8.660 -3.334 1.00 9.65 ? 237 LEU A CD2 1 ATOM 1741 N N . VAL A 1 254 ? -29.654 11.103 1.573 1.00 16.17 ? 238 VAL A N 1 ATOM 1742 C CA . VAL A 1 254 ? -29.108 11.201 2.922 1.00 9.93 ? 238 VAL A CA 1 ATOM 1743 C C . VAL A 1 254 ? -30.184 10.971 3.975 1.00 16.34 ? 238 VAL A C 1 ATOM 1744 O O . VAL A 1 254 ? -31.292 11.500 3.873 1.00 16.63 ? 238 VAL A O 1 ATOM 1745 C CB . VAL A 1 254 ? -28.455 12.571 3.156 1.00 11.01 ? 238 VAL A CB 1 ATOM 1746 C CG1 . VAL A 1 254 ? -27.986 12.697 4.592 1.00 15.08 ? 238 VAL A CG1 1 ATOM 1747 C CG2 . VAL A 1 254 ? -27.293 12.763 2.199 1.00 7.35 ? 238 VAL A CG2 1 ATOM 1748 N N . THR A 1 255 ? -29.843 10.184 4.991 1.00 14.12 ? 239 THR A N 1 ATOM 1749 C CA . THR A 1 255 ? -30.778 9.843 6.056 1.00 11.56 ? 239 THR A CA 1 ATOM 1750 C C . THR A 1 255 ? -30.195 10.172 7.426 1.00 14.71 ? 239 THR A C 1 ATOM 1751 O O . THR A 1 255 ? -29.285 9.496 7.904 1.00 14.41 ? 239 THR A O 1 ATOM 1752 C CB . THR A 1 255 ? -31.133 8.343 6.028 1.00 15.75 ? 239 THR A CB 1 ATOM 1753 O OG1 . THR A 1 255 ? -31.779 8.020 4.790 1.00 24.51 ? 239 THR A OG1 1 ATOM 1754 C CG2 . THR A 1 255 ? -32.054 7.985 7.187 1.00 15.74 ? 239 THR A CG2 1 ATOM 1755 N N . PHE A 1 256 ? -30.723 11.219 8.050 1.00 16.76 ? 240 PHE A N 1 ATOM 1756 C CA . PHE A 1 256 ? -30.356 11.561 9.418 1.00 7.46 ? 240 PHE A CA 1 ATOM 1757 C C . PHE A 1 256 ? -31.041 10.613 10.392 1.00 12.68 ? 240 PHE A C 1 ATOM 1758 O O . PHE A 1 256 ? -32.251 10.695 10.599 1.00 16.28 ? 240 PHE A O 1 ATOM 1759 C CB . PHE A 1 256 ? -30.766 12.999 9.740 1.00 9.42 ? 240 PHE A CB 1 ATOM 1760 C CG . PHE A 1 256 ? -29.849 14.041 9.161 1.00 16.07 ? 240 PHE A CG 1 ATOM 1761 C CD1 . PHE A 1 256 ? -29.864 14.326 7.806 1.00 14.36 ? 240 PHE A CD1 1 ATOM 1762 C CD2 . PHE A 1 256 ? -28.978 14.744 9.978 1.00 10.28 ? 240 PHE A CD2 1 ATOM 1763 C CE1 . PHE A 1 256 ? -29.022 15.287 7.277 1.00 6.94 ? 240 PHE A CE1 1 ATOM 1764 C CE2 . PHE A 1 256 ? -28.137 15.705 9.454 1.00 6.05 ? 240 PHE A CE2 1 ATOM 1765 C CZ . PHE A 1 256 ? -28.158 15.976 8.103 1.00 7.42 ? 240 PHE A CZ 1 ATOM 1766 N N . LYS A 1 257 ? -30.267 9.712 10.988 1.00 11.16 ? 241 LYS A N 1 ATOM 1767 C CA . LYS A 1 257 ? -30.809 8.788 11.974 1.00 12.40 ? 241 LYS A CA 1 ATOM 1768 C C . LYS A 1 257 ? -31.276 9.583 13.186 1.00 11.63 ? 241 LYS A C 1 ATOM 1769 O O . LYS A 1 257 ? -31.045 10.788 13.269 1.00 11.15 ? 241 LYS A O 1 ATOM 1770 C CB . LYS A 1 257 ? -29.758 7.755 12.386 1.00 16.53 ? 241 LYS A CB 1 ATOM 1771 C CG . LYS A 1 257 ? -29.149 6.979 11.223 1.00 16.26 ? 241 LYS A CG 1 ATOM 1772 C CD . LYS A 1 257 ? -30.213 6.373 10.320 1.00 16.16 ? 241 LYS A CD 1 ATOM 1773 C CE . LYS A 1 257 ? -31.022 5.304 11.037 1.00 25.35 ? 241 LYS A CE 1 ATOM 1774 N NZ . LYS A 1 257 ? -32.206 4.877 10.243 1.00 29.91 ? 241 LYS A NZ 1 ATOM 1775 N N . THR A 1 258 ? -31.936 8.912 14.124 1.00 14.68 ? 242 THR A N 1 ATOM 1776 C CA A THR A 1 258 ? -32.434 9.578 15.321 0.34 14.69 ? 242 THR A CA 1 ATOM 1777 C CA B THR A 1 258 ? -32.438 9.577 15.320 0.66 14.53 ? 242 THR A CA 1 ATOM 1778 C C . THR A 1 258 ? -31.289 10.217 16.092 1.00 14.42 ? 242 THR A C 1 ATOM 1779 O O . THR A 1 258 ? -30.229 9.615 16.263 1.00 14.85 ? 242 THR A O 1 ATOM 1780 C CB A THR A 1 258 ? -33.179 8.600 16.246 0.34 16.37 ? 242 THR A CB 1 ATOM 1781 C CB B THR A 1 258 ? -33.182 8.597 16.247 0.66 16.33 ? 242 THR A CB 1 ATOM 1782 O OG1 A THR A 1 258 ? -32.425 7.389 16.376 0.34 16.51 ? 242 THR A OG1 1 ATOM 1783 O OG1 B THR A 1 258 ? -34.304 8.032 15.557 0.66 22.64 ? 242 THR A OG1 1 ATOM 1784 C CG2 A THR A 1 258 ? -34.558 8.281 15.685 0.34 20.80 ? 242 THR A CG2 1 ATOM 1785 C CG2 B THR A 1 258 ? -33.676 9.314 17.494 0.66 17.17 ? 242 THR A CG2 1 ATOM 1786 N N . ALA A 1 259 ? -31.509 11.442 16.557 1.00 13.27 ? 243 ALA A N 1 ATOM 1787 C CA . ALA A 1 259 ? -30.477 12.188 17.263 1.00 11.56 ? 243 ALA A CA 1 ATOM 1788 C C . ALA A 1 259 ? -30.403 11.794 18.731 1.00 15.43 ? 243 ALA A C 1 ATOM 1789 O O . ALA A 1 259 ? -31.394 11.375 19.329 1.00 16.64 ? 243 ALA A O 1 ATOM 1790 C CB . ALA A 1 259 ? -30.732 13.682 17.137 1.00 10.55 ? 243 ALA A CB 1 ATOM 1791 N N . HIS A 1 260 ? -29.210 11.929 19.299 1.00 15.95 ? 244 HIS A N 1 ATOM 1792 C CA . HIS A 1 260 ? -29.006 11.751 20.728 1.00 11.14 ? 244 HIS A CA 1 ATOM 1793 C C . HIS A 1 260 ? -28.554 13.081 21.318 1.00 10.46 ? 244 HIS A C 1 ATOM 1794 O O . HIS A 1 260 ? -28.294 14.035 20.585 1.00 15.11 ? 244 HIS A O 1 ATOM 1795 C CB . HIS A 1 260 ? -27.965 10.662 20.996 1.00 15.36 ? 244 HIS A CB 1 ATOM 1796 C CG . HIS A 1 260 ? -28.354 9.314 20.471 1.00 23.44 ? 244 HIS A CG 1 ATOM 1797 N ND1 . HIS A 1 260 ? -28.037 8.892 19.197 1.00 24.58 ? 244 HIS A ND1 1 ATOM 1798 C CD2 . HIS A 1 260 ? -29.037 8.298 21.047 1.00 25.42 ? 244 HIS A CD2 1 ATOM 1799 C CE1 . HIS A 1 260 ? -28.505 7.670 19.014 1.00 25.13 ? 244 HIS A CE1 1 ATOM 1800 N NE2 . HIS A 1 260 ? -29.117 7.286 20.118 1.00 24.61 ? 244 HIS A NE2 1 ATOM 1801 N N . ALA A 1 261 ? -28.461 13.142 22.641 1.00 13.49 ? 245 ALA A N 1 ATOM 1802 C CA . ALA A 1 261 ? -28.112 14.378 23.333 1.00 7.74 ? 245 ALA A CA 1 ATOM 1803 C C . ALA A 1 261 ? -27.002 15.152 22.624 1.00 8.60 ? 245 ALA A C 1 ATOM 1804 O O . ALA A 1 261 ? -27.141 16.346 22.359 1.00 9.83 ? 245 ALA A O 1 ATOM 1805 C CB . ALA A 1 261 ? -27.700 14.076 24.763 1.00 7.20 ? 245 ALA A CB 1 ATOM 1806 N N . LYS A 1 262 ? -25.905 14.467 22.316 1.00 11.59 ? 246 LYS A N 1 ATOM 1807 C CA . LYS A 1 262 ? -24.705 15.136 21.823 1.00 8.89 ? 246 LYS A CA 1 ATOM 1808 C C . LYS A 1 262 ? -24.202 14.605 20.481 1.00 8.90 ? 246 LYS A C 1 ATOM 1809 O O . LYS A 1 262 ? -23.197 15.090 19.961 1.00 10.40 ? 246 LYS A O 1 ATOM 1810 C CB . LYS A 1 262 ? -23.589 15.003 22.859 1.00 10.27 ? 246 LYS A CB 1 ATOM 1811 C CG . LYS A 1 262 ? -23.931 15.596 24.215 1.00 9.72 ? 246 LYS A CG 1 ATOM 1812 C CD . LYS A 1 262 ? -23.019 15.049 25.296 1.00 9.16 ? 246 LYS A CD 1 ATOM 1813 C CE . LYS A 1 262 ? -23.134 15.848 26.579 1.00 11.84 ? 246 LYS A CE 1 ATOM 1814 N NZ . LYS A 1 262 ? -22.185 15.360 27.617 1.00 14.28 ? 246 LYS A NZ 1 ATOM 1815 N N . LYS A 1 263 ? -24.888 13.614 19.920 1.00 10.10 ? 247 LYS A N 1 ATOM 1816 C CA . LYS A 1 263 ? -24.449 13.024 18.659 1.00 8.61 ? 247 LYS A CA 1 ATOM 1817 C C . LYS A 1 263 ? -25.625 12.528 17.828 1.00 8.14 ? 247 LYS A C 1 ATOM 1818 O O . LYS A 1 263 ? -26.724 12.331 18.342 1.00 13.24 ? 247 LYS A O 1 ATOM 1819 C CB . LYS A 1 263 ? -23.473 11.876 18.920 1.00 9.19 ? 247 LYS A CB 1 ATOM 1820 C CG . LYS A 1 263 ? -24.107 10.645 19.547 1.00 14.93 ? 247 LYS A CG 1 ATOM 1821 C CD . LYS A 1 263 ? -23.067 9.576 19.835 1.00 15.63 ? 247 LYS A CD 1 ATOM 1822 C CE . LYS A 1 263 ? -23.715 8.242 20.161 1.00 20.30 ? 247 LYS A CE 1 ATOM 1823 N NZ . LYS A 1 263 ? -22.703 7.187 20.441 1.00 38.09 ? 247 LYS A NZ 1 ATOM 1824 N N . GLN A 1 264 ? -25.377 12.327 16.539 1.00 7.02 ? 248 GLN A N 1 ATOM 1825 C CA . GLN A 1 264 ? -26.406 11.875 15.615 1.00 7.46 ? 248 GLN A CA 1 ATOM 1826 C C . GLN A 1 264 ? -25.749 11.336 14.357 1.00 8.06 ? 248 GLN A C 1 ATOM 1827 O O . GLN A 1 264 ? -24.920 12.010 13.747 1.00 7.34 ? 248 GLN A O 1 ATOM 1828 C CB . GLN A 1 264 ? -27.326 13.038 15.250 1.00 9.44 ? 248 GLN A CB 1 ATOM 1829 C CG . GLN A 1 264 ? -28.461 12.676 14.296 1.00 10.12 ? 248 GLN A CG 1 ATOM 1830 C CD . GLN A 1 264 ? -29.287 13.884 13.888 1.00 10.36 ? 248 GLN A CD 1 ATOM 1831 O OE1 . GLN A 1 264 ? -28.809 15.017 13.923 1.00 14.53 ? 248 GLN A OE1 1 ATOM 1832 N NE2 . GLN A 1 264 ? -30.536 13.647 13.503 1.00 8.33 ? 248 GLN A NE2 1 ATOM 1833 N N . GLU A 1 265 ? -26.125 10.124 13.963 1.00 12.51 ? 249 GLU A N 1 ATOM 1834 C CA . GLU A 1 265 ? -25.527 9.493 12.794 1.00 14.09 ? 249 GLU A CA 1 ATOM 1835 C C . GLU A 1 265 ? -26.224 9.928 11.511 1.00 11.60 ? 249 GLU A C 1 ATOM 1836 O O . GLU A 1 265 ? -27.443 10.092 11.476 1.00 8.62 ? 249 GLU A O 1 ATOM 1837 C CB . GLU A 1 265 ? -25.587 7.970 12.915 1.00 15.02 ? 249 GLU A CB 1 ATOM 1838 C CG . GLU A 1 265 ? -24.808 7.240 11.832 1.00 14.38 ? 249 GLU A CG 1 ATOM 1839 C CD . GLU A 1 265 ? -25.008 5.739 11.878 1.00 20.33 ? 249 GLU A CD 1 ATOM 1840 O OE1 . GLU A 1 265 ? -26.063 5.294 12.375 1.00 27.49 ? 249 GLU A OE1 1 ATOM 1841 O OE2 . GLU A 1 265 ? -24.109 5.003 11.418 1.00 26.17 ? 249 GLU A OE2 1 ATOM 1842 N N . VAL A 1 266 ? -25.432 10.119 10.462 1.00 9.20 ? 250 VAL A N 1 ATOM 1843 C CA . VAL A 1 266 ? -25.962 10.392 9.135 1.00 8.47 ? 250 VAL A CA 1 ATOM 1844 C C . VAL A 1 266 ? -25.532 9.279 8.189 1.00 8.27 ? 250 VAL A C 1 ATOM 1845 O O . VAL A 1 266 ? -24.339 9.036 8.008 1.00 11.06 ? 250 VAL A O 1 ATOM 1846 C CB . VAL A 1 266 ? -25.456 11.738 8.585 1.00 6.96 ? 250 VAL A CB 1 ATOM 1847 C CG1 . VAL A 1 266 ? -26.033 11.996 7.202 1.00 8.48 ? 250 VAL A CG1 1 ATOM 1848 C CG2 . VAL A 1 266 ? -25.812 12.871 9.536 1.00 6.87 ? 250 VAL A CG2 1 ATOM 1849 N N . VAL A 1 267 ? -26.506 8.605 7.586 1.00 10.68 ? 251 VAL A N 1 ATOM 1850 C CA . VAL A 1 267 ? -26.222 7.511 6.668 1.00 15.61 ? 251 VAL A CA 1 ATOM 1851 C C . VAL A 1 267 ? -26.684 7.888 5.267 1.00 9.90 ? 251 VAL A C 1 ATOM 1852 O O . VAL A 1 267 ? -27.429 8.850 5.090 1.00 12.45 ? 251 VAL A O 1 ATOM 1853 C CB . VAL A 1 267 ? -26.903 6.200 7.116 1.00 14.60 ? 251 VAL A CB 1 ATOM 1854 C CG1 . VAL A 1 267 ? -26.535 5.882 8.557 1.00 16.18 ? 251 VAL A CG1 1 ATOM 1855 C CG2 . VAL A 1 267 ? -28.408 6.296 6.962 1.00 17.28 ? 251 VAL A CG2 1 ATOM 1856 N N . VAL A 1 268 ? -26.241 7.128 4.273 1.00 12.33 ? 252 VAL A N 1 ATOM 1857 C CA . VAL A 1 268 ? -26.539 7.451 2.883 1.00 14.80 ? 252 VAL A CA 1 ATOM 1858 C C . VAL A 1 268 ? -27.082 6.233 2.138 1.00 13.11 ? 252 VAL A C 1 ATOM 1859 O O . VAL A 1 268 ? -26.678 5.101 2.403 1.00 11.60 ? 252 VAL A O 1 ATOM 1860 C CB . VAL A 1 268 ? -25.281 7.982 2.159 1.00 11.73 ? 252 VAL A CB 1 ATOM 1861 C CG1 . VAL A 1 268 ? -24.394 6.832 1.700 1.00 7.71 ? 252 VAL A CG1 1 ATOM 1862 C CG2 . VAL A 1 268 ? -25.672 8.860 0.984 1.00 11.26 ? 252 VAL A CG2 1 ATOM 1863 N N . LEU A 1 269 ? -28.008 6.475 1.215 1.00 13.91 ? 253 LEU A N 1 ATOM 1864 C CA . LEU A 1 269 ? -28.578 5.408 0.398 1.00 8.97 ? 253 LEU A CA 1 ATOM 1865 C C . LEU A 1 269 ? -27.491 4.729 -0.427 1.00 9.29 ? 253 LEU A C 1 ATOM 1866 O O . LEU A 1 269 ? -26.400 5.272 -0.601 1.00 12.66 ? 253 LEU A O 1 ATOM 1867 C CB . LEU A 1 269 ? -29.658 5.967 -0.532 1.00 8.26 ? 253 LEU A CB 1 ATOM 1868 C CG . LEU A 1 269 ? -31.042 6.242 0.069 1.00 14.73 ? 253 LEU A CG 1 ATOM 1869 C CD1 . LEU A 1 269 ? -31.813 4.945 0.280 1.00 26.29 ? 253 LEU A CD1 1 ATOM 1870 C CD2 . LEU A 1 269 ? -30.944 7.022 1.376 1.00 24.75 ? 253 LEU A CD2 1 ATOM 1871 N N . GLY A 1 270 ? -27.793 3.539 -0.934 1.00 11.32 ? 254 GLY A N 1 ATOM 1872 C CA . GLY A 1 270 ? -26.859 2.813 -1.774 1.00 13.01 ? 254 GLY A CA 1 ATOM 1873 C C . GLY A 1 270 ? -26.938 3.289 -3.210 1.00 10.06 ? 254 GLY A C 1 ATOM 1874 O O . GLY A 1 270 ? -27.740 4.162 -3.538 1.00 11.10 ? 254 GLY A O 1 ATOM 1875 N N . SER A 1 271 ? -26.099 2.720 -4.068 1.00 14.61 ? 255 SER A N 1 ATOM 1876 C CA . SER A 1 271 ? -26.105 3.066 -5.483 1.00 11.14 ? 255 SER A CA 1 ATOM 1877 C C . SER A 1 271 ? -27.488 2.848 -6.079 1.00 8.31 ? 255 SER A C 1 ATOM 1878 O O . SER A 1 271 ? -28.158 1.862 -5.775 1.00 15.11 ? 255 SER A O 1 ATOM 1879 C CB . SER A 1 271 ? -25.071 2.231 -6.239 1.00 17.39 ? 255 SER A CB 1 ATOM 1880 O OG . SER A 1 271 ? -25.145 2.464 -7.635 1.00 12.45 ? 255 SER A OG 1 ATOM 1881 N N . GLN A 1 272 ? -27.908 3.779 -6.928 1.00 15.73 ? 256 GLN A N 1 ATOM 1882 C CA . GLN A 1 272 ? -29.224 3.713 -7.546 1.00 15.40 ? 256 GLN A CA 1 ATOM 1883 C C . GLN A 1 272 ? -29.109 3.310 -9.012 1.00 10.48 ? 256 GLN A C 1 ATOM 1884 O O . GLN A 1 272 ? -30.007 3.578 -9.811 1.00 13.57 ? 256 GLN A O 1 ATOM 1885 C CB . GLN A 1 272 ? -29.935 5.062 -7.421 1.00 10.74 ? 256 GLN A CB 1 ATOM 1886 C CG . GLN A 1 272 ? -30.200 5.486 -5.983 1.00 15.61 ? 256 GLN A CG 1 ATOM 1887 C CD . GLN A 1 272 ? -31.145 4.543 -5.264 1.00 15.69 ? 256 GLN A CD 1 ATOM 1888 O OE1 . GLN A 1 272 ? -32.214 4.210 -5.775 1.00 13.70 ? 256 GLN A OE1 1 ATOM 1889 N NE2 . GLN A 1 272 ? -30.751 4.101 -4.074 1.00 14.61 ? 256 GLN A NE2 1 ATOM 1890 N N . GLU A 1 273 ? -28.001 2.666 -9.362 1.00 8.83 ? 257 GLU A N 1 ATOM 1891 C CA . GLU A 1 273 ? -27.783 2.222 -10.733 1.00 15.46 ? 257 GLU A CA 1 ATOM 1892 C C . GLU A 1 273 ? -28.799 1.159 -11.134 1.00 12.01 ? 257 GLU A C 1 ATOM 1893 O O . GLU A 1 273 ? -29.239 1.113 -12.283 1.00 15.29 ? 257 GLU A O 1 ATOM 1894 C CB . GLU A 1 273 ? -26.368 1.670 -10.894 1.00 19.90 ? 257 GLU A CB 1 ATOM 1895 C CG . GLU A 1 273 ? -26.133 0.941 -12.198 1.00 17.29 ? 257 GLU A CG 1 ATOM 1896 C CD . GLU A 1 273 ? -24.704 0.464 -12.322 1.00 20.30 ? 257 GLU A CD 1 ATOM 1897 O OE1 . GLU A 1 273 ? -23.923 0.696 -11.375 1.00 24.09 ? 257 GLU A OE1 1 ATOM 1898 O OE2 . GLU A 1 273 ? -24.359 -0.143 -13.358 1.00 28.66 ? 257 GLU A OE2 1 ATOM 1899 N N . GLY A 1 274 ? -29.162 0.304 -10.184 1.00 17.00 ? 258 GLY A N 1 ATOM 1900 C CA . GLY A 1 274 ? -30.123 -0.753 -10.438 1.00 12.16 ? 258 GLY A CA 1 ATOM 1901 C C . GLY A 1 274 ? -31.533 -0.219 -10.595 1.00 14.35 ? 258 GLY A C 1 ATOM 1902 O O . GLY A 1 274 ? -32.289 -0.679 -11.450 1.00 22.13 ? 258 GLY A O 1 ATOM 1903 N N . ALA A 1 275 ? -31.890 0.752 -9.761 1.00 12.47 ? 259 ALA A N 1 ATOM 1904 C CA . ALA A 1 275 ? -33.216 1.354 -9.811 1.00 11.31 ? 259 ALA A CA 1 ATOM 1905 C C . ALA A 1 275 ? -33.422 2.113 -11.118 1.00 9.93 ? 259 ALA A C 1 ATOM 1906 O O . ALA A 1 275 ? -34.547 2.249 -11.599 1.00 10.16 ? 259 ALA A O 1 ATOM 1907 C CB . ALA A 1 275 ? -33.413 2.278 -8.626 1.00 12.23 ? 259 ALA A CB 1 ATOM 1908 N N . MET A 1 276 ? -32.326 2.602 -11.688 1.00 15.46 ? 260 MET A N 1 ATOM 1909 C CA . MET A 1 276 ? -32.372 3.331 -12.946 1.00 14.13 ? 260 MET A CA 1 ATOM 1910 C C . MET A 1 276 ? -32.440 2.371 -14.126 1.00 13.33 ? 260 MET A C 1 ATOM 1911 O O . MET A 1 276 ? -33.248 2.551 -15.038 1.00 16.41 ? 260 MET A O 1 ATOM 1912 C CB . MET A 1 276 ? -31.134 4.214 -13.072 1.00 11.29 ? 260 MET A CB 1 ATOM 1913 C CG . MET A 1 276 ? -31.234 5.541 -12.340 1.00 12.25 ? 260 MET A CG 1 ATOM 1914 S SD . MET A 1 276 ? -32.626 6.550 -12.891 1.00 17.31 ? 260 MET A SD 1 ATOM 1915 C CE . MET A 1 276 ? -32.457 6.420 -14.668 1.00 3.49 ? 260 MET A CE 1 ATOM 1916 N N . HIS A 1 277 ? -31.579 1.358 -14.107 1.00 13.69 ? 261 HIS A N 1 ATOM 1917 C CA . HIS A 1 277 ? -31.581 0.334 -15.143 1.00 10.89 ? 261 HIS A CA 1 ATOM 1918 C C . HIS A 1 277 ? -32.992 -0.205 -15.354 1.00 8.99 ? 261 HIS A C 1 ATOM 1919 O O . HIS A 1 277 ? -33.417 -0.434 -16.486 1.00 20.78 ? 261 HIS A O 1 ATOM 1920 C CB . HIS A 1 277 ? -30.645 -0.817 -14.766 1.00 12.14 ? 261 HIS A CB 1 ATOM 1921 C CG . HIS A 1 277 ? -29.195 -0.544 -15.039 1.00 12.38 ? 261 HIS A CG 1 ATOM 1922 N ND1 . HIS A 1 277 ? -28.767 0.377 -15.968 1.00 18.00 ? 261 HIS A ND1 1 ATOM 1923 C CD2 . HIS A 1 277 ? -28.077 -1.085 -14.500 1.00 19.98 ? 261 HIS A CD2 1 ATOM 1924 C CE1 . HIS A 1 277 ? -27.444 0.394 -15.991 1.00 19.06 ? 261 HIS A CE1 1 ATOM 1925 N NE2 . HIS A 1 277 ? -27.002 -0.483 -15.109 1.00 23.61 ? 261 HIS A NE2 1 ATOM 1926 N N . THR A 1 278 ? -33.715 -0.405 -14.258 1.00 12.86 ? 262 THR A N 1 ATOM 1927 C CA . THR A 1 278 ? -35.068 -0.937 -14.324 1.00 10.92 ? 262 THR A CA 1 ATOM 1928 C C . THR A 1 278 ? -36.040 0.098 -14.882 1.00 13.28 ? 262 THR A C 1 ATOM 1929 O O . THR A 1 278 ? -36.933 -0.234 -15.660 1.00 18.05 ? 262 THR A O 1 ATOM 1930 C CB . THR A 1 278 ? -35.550 -1.386 -12.937 1.00 11.80 ? 262 THR A CB 1 ATOM 1931 O OG1 . THR A 1 278 ? -34.709 -2.442 -12.453 1.00 12.52 ? 262 THR A OG1 1 ATOM 1932 C CG2 . THR A 1 278 ? -36.978 -1.884 -13.005 1.00 15.03 ? 262 THR A CG2 1 ATOM 1933 N N . ALA A 1 279 ? -35.860 1.353 -14.483 1.00 18.83 ? 263 ALA A N 1 ATOM 1934 C CA . ALA A 1 279 ? -36.715 2.435 -14.956 1.00 13.98 ? 263 ALA A CA 1 ATOM 1935 C C . ALA A 1 279 ? -36.435 2.750 -16.423 1.00 15.78 ? 263 ALA A C 1 ATOM 1936 O O . ALA A 1 279 ? -37.291 3.286 -17.127 1.00 16.55 ? 263 ALA A O 1 ATOM 1937 C CB . ALA A 1 279 ? -36.514 3.675 -14.104 1.00 9.29 ? 263 ALA A CB 1 ATOM 1938 N N . LEU A 1 280 ? -35.231 2.416 -16.876 1.00 19.57 ? 264 LEU A N 1 ATOM 1939 C CA . LEU A 1 280 ? -34.839 2.650 -18.261 1.00 18.46 ? 264 LEU A CA 1 ATOM 1940 C C . LEU A 1 280 ? -35.246 1.492 -19.168 1.00 20.61 ? 264 LEU A C 1 ATOM 1941 O O . LEU A 1 280 ? -35.038 1.545 -20.379 1.00 25.11 ? 264 LEU A O 1 ATOM 1942 C CB . LEU A 1 280 ? -33.327 2.867 -18.351 1.00 14.78 ? 264 LEU A CB 1 ATOM 1943 C CG . LEU A 1 280 ? -32.818 4.233 -17.888 1.00 8.88 ? 264 LEU A CG 1 ATOM 1944 C CD1 . LEU A 1 280 ? -31.338 4.162 -17.553 1.00 6.09 ? 264 LEU A CD1 1 ATOM 1945 C CD2 . LEU A 1 280 ? -33.072 5.282 -18.958 1.00 7.74 ? 264 LEU A CD2 1 ATOM 1946 N N . THR A 1 281 ? -35.823 0.446 -18.582 1.00 19.45 ? 265 THR A N 1 ATOM 1947 C CA . THR A 1 281 ? -36.249 -0.717 -19.353 1.00 19.07 ? 265 THR A CA 1 ATOM 1948 C C . THR A 1 281 ? -37.201 -0.290 -20.464 1.00 17.80 ? 265 THR A C 1 ATOM 1949 O O . THR A 1 281 ? -38.269 0.262 -20.200 1.00 23.98 ? 265 THR A O 1 ATOM 1950 C CB . THR A 1 281 ? -36.949 -1.764 -18.465 1.00 22.34 ? 265 THR A CB 1 ATOM 1951 O OG1 . THR A 1 281 ? -36.028 -2.263 -17.488 1.00 15.30 ? 265 THR A OG1 1 ATOM 1952 C CG2 . THR A 1 281 ? -37.460 -2.929 -19.304 1.00 27.12 ? 265 THR A CG2 1 ATOM 1953 N N . GLY A 1 282 ? -36.806 -0.549 -21.705 1.00 16.95 ? 266 GLY A N 1 ATOM 1954 C CA . GLY A 1 282 ? -37.605 -0.174 -22.857 1.00 20.59 ? 266 GLY A CA 1 ATOM 1955 C C . GLY A 1 282 ? -36.986 0.988 -23.610 1.00 18.98 ? 266 GLY A C 1 ATOM 1956 O O . GLY A 1 282 ? -36.943 0.988 -24.840 1.00 15.22 ? 266 GLY A O 1 ATOM 1957 N N . ALA A 1 283 ? -36.506 1.982 -22.867 1.00 22.44 ? 267 ALA A N 1 ATOM 1958 C CA . ALA A 1 283 ? -35.843 3.136 -23.464 1.00 15.74 ? 267 ALA A CA 1 ATOM 1959 C C . ALA A 1 283 ? -34.751 2.670 -24.419 1.00 9.01 ? 267 ALA A C 1 ATOM 1960 O O . ALA A 1 283 ? -33.981 1.766 -24.099 1.00 11.87 ? 267 ALA A O 1 ATOM 1961 C CB . ALA A 1 283 ? -35.257 4.034 -22.381 1.00 8.19 ? 267 ALA A CB 1 ATOM 1962 N N . THR A 1 284 ? -34.691 3.290 -25.592 1.00 9.99 ? 268 THR A N 1 ATOM 1963 C CA . THR A 1 284 ? -33.730 2.898 -26.613 1.00 7.18 ? 268 THR A CA 1 ATOM 1964 C C . THR A 1 284 ? -32.298 3.078 -26.122 1.00 11.02 ? 268 THR A C 1 ATOM 1965 O O . THR A 1 284 ? -31.914 4.163 -25.691 1.00 11.67 ? 268 THR A O 1 ATOM 1966 C CB . THR A 1 284 ? -33.909 3.729 -27.893 1.00 8.48 ? 268 THR A CB 1 ATOM 1967 O OG1 . THR A 1 284 ? -35.243 3.575 -28.391 1.00 11.76 ? 268 THR A OG1 1 ATOM 1968 C CG2 . THR A 1 284 ? -32.919 3.286 -28.959 1.00 10.63 ? 268 THR A CG2 1 ATOM 1969 N N . GLU A 1 285 ? -31.516 2.005 -26.189 1.00 15.64 ? 269 GLU A N 1 ATOM 1970 C CA . GLU A 1 285 ? -30.099 2.057 -25.850 1.00 11.19 ? 269 GLU A CA 1 ATOM 1971 C C . GLU A 1 285 ? -29.312 2.469 -27.090 1.00 14.67 ? 269 GLU A C 1 ATOM 1972 O O . GLU A 1 285 ? -29.714 2.159 -28.211 1.00 14.00 ? 269 GLU A O 1 ATOM 1973 C CB . GLU A 1 285 ? -29.627 0.690 -25.356 1.00 11.96 ? 269 GLU A CB 1 ATOM 1974 C CG . GLU A 1 285 ? -28.329 0.723 -24.560 1.00 20.41 ? 269 GLU A CG 1 ATOM 1975 C CD . GLU A 1 285 ? -27.878 -0.657 -24.118 1.00 31.28 ? 269 GLU A CD 1 ATOM 1976 O OE1 . GLU A 1 285 ? -28.747 -1.520 -23.873 1.00 41.94 ? 269 GLU A OE1 1 ATOM 1977 O OE2 . GLU A 1 285 ? -26.654 -0.881 -24.019 1.00 26.81 ? 269 GLU A OE2 1 ATOM 1978 N N . ILE A 1 286 ? -28.195 3.165 -26.896 1.00 13.66 ? 270 ILE A N 1 ATOM 1979 C CA . ILE A 1 286 ? -27.427 3.674 -28.026 1.00 12.44 ? 270 ILE A CA 1 ATOM 1980 C C . ILE A 1 286 ? -25.923 3.559 -27.788 1.00 18.61 ? 270 ILE A C 1 ATOM 1981 O O . ILE A 1 286 ? -25.467 3.450 -26.649 1.00 19.66 ? 270 ILE A O 1 ATOM 1982 C CB . ILE A 1 286 ? -27.802 5.139 -28.335 1.00 18.33 ? 270 ILE A CB 1 ATOM 1983 C CG1 . ILE A 1 286 ? -27.210 5.574 -29.677 1.00 22.28 ? 270 ILE A CG1 1 ATOM 1984 C CG2 . ILE A 1 286 ? -27.338 6.054 -27.215 1.00 18.53 ? 270 ILE A CG2 1 ATOM 1985 C CD1 . ILE A 1 286 ? -27.939 6.736 -30.314 1.00 26.31 ? 270 ILE A CD1 1 ATOM 1986 N N . GLN A 1 287 ? -25.160 3.585 -28.876 1.00 21.23 ? 271 GLN A N 1 ATOM 1987 C CA . GLN A 1 287 ? -23.714 3.403 -28.815 1.00 29.35 ? 271 GLN A CA 1 ATOM 1988 C C . GLN A 1 287 ? -22.991 4.738 -28.961 1.00 22.65 ? 271 GLN A C 1 ATOM 1989 O O . GLN A 1 287 ? -23.207 5.469 -29.929 1.00 20.20 ? 271 GLN A O 1 ATOM 1990 C CB . GLN A 1 287 ? -23.261 2.437 -29.914 1.00 27.98 ? 271 GLN A CB 1 ATOM 1991 C CG . GLN A 1 287 ? -23.510 2.946 -31.328 1.00 29.03 ? 271 GLN A CG 1 ATOM 1992 C CD . GLN A 1 287 ? -23.370 1.862 -32.379 1.00 38.15 ? 271 GLN A CD 1 ATOM 1993 O OE1 . GLN A 1 287 ? -24.266 1.657 -33.199 1.00 36.95 ? 271 GLN A OE1 1 ATOM 1994 N NE2 . GLN A 1 287 ? -22.240 1.166 -32.366 1.00 37.04 ? 271 GLN A NE2 1 ATOM 1995 N N . THR A 1 288 ? -22.139 5.055 -27.990 1.00 21.11 ? 272 THR A N 1 ATOM 1996 C CA . THR A 1 288 ? -21.373 6.295 -28.023 1.00 23.61 ? 272 THR A CA 1 ATOM 1997 C C . THR A 1 288 ? -19.951 6.101 -27.512 1.00 32.12 ? 272 THR A C 1 ATOM 1998 O O . THR A 1 288 ? -19.741 5.781 -26.342 1.00 34.71 ? 272 THR A O 1 ATOM 1999 C CB . THR A 1 288 ? -22.044 7.389 -27.174 1.00 26.21 ? 272 THR A CB 1 ATOM 2000 O OG1 . THR A 1 288 ? -21.192 7.735 -26.075 1.00 27.75 ? 272 THR A OG1 1 ATOM 2001 C CG2 . THR A 1 288 ? -23.385 6.910 -26.639 1.00 22.85 ? 272 THR A CG2 1 ATOM 2002 N N . SER A 1 289 ? -18.979 6.307 -28.395 1.00 31.84 ? 273 SER A N 1 ATOM 2003 C CA . SER A 1 289 ? -17.572 6.242 -28.020 1.00 23.55 ? 273 SER A CA 1 ATOM 2004 C C . SER A 1 289 ? -17.038 7.643 -27.765 1.00 24.96 ? 273 SER A C 1 ATOM 2005 O O . SER A 1 289 ? -16.877 8.436 -28.693 1.00 24.85 ? 273 SER A O 1 ATOM 2006 C CB . SER A 1 289 ? -16.754 5.566 -29.121 1.00 33.70 ? 273 SER A CB 1 ATOM 2007 O OG . SER A 1 289 ? -15.370 5.604 -28.818 1.00 47.57 ? 273 SER A OG 1 ATOM 2008 N N . GLY A 1 290 ? -16.770 7.943 -26.500 1.00 23.83 ? 274 GLY A N 1 ATOM 2009 C CA . GLY A 1 290 ? -16.280 9.252 -26.113 1.00 22.99 ? 274 GLY A CA 1 ATOM 2010 C C . GLY A 1 290 ? -17.379 10.296 -26.130 1.00 24.72 ? 274 GLY A C 1 ATOM 2011 O O . GLY A 1 290 ? -18.371 10.180 -25.410 1.00 22.35 ? 274 GLY A O 1 ATOM 2012 N N . THR A 1 291 ? -17.199 11.321 -26.957 1.00 32.13 ? 275 THR A N 1 ATOM 2013 C CA . THR A 1 291 ? -18.175 12.397 -27.071 1.00 20.08 ? 275 THR A CA 1 ATOM 2014 C C . THR A 1 291 ? -19.013 12.263 -28.338 1.00 14.98 ? 275 THR A C 1 ATOM 2015 O O . THR A 1 291 ? -19.722 13.192 -28.719 1.00 13.32 ? 275 THR A O 1 ATOM 2016 C CB . THR A 1 291 ? -17.485 13.774 -27.089 1.00 24.43 ? 275 THR A CB 1 ATOM 2017 O OG1 . THR A 1 291 ? -16.618 13.862 -28.227 1.00 29.47 ? 275 THR A OG1 1 ATOM 2018 C CG2 . THR A 1 291 ? -16.676 13.989 -25.816 1.00 25.42 ? 275 THR A CG2 1 ATOM 2019 N N . THR A 1 292 ? -18.927 11.107 -28.990 1.00 18.50 ? 276 THR A N 1 ATOM 2020 C CA . THR A 1 292 ? -19.642 10.880 -30.240 1.00 12.51 ? 276 THR A CA 1 ATOM 2021 C C . THR A 1 292 ? -20.685 9.779 -30.088 1.00 12.63 ? 276 THR A C 1 ATOM 2022 O O . THR A 1 292 ? -20.414 8.734 -29.497 1.00 17.46 ? 276 THR A O 1 ATOM 2023 C CB . THR A 1 292 ? -18.670 10.486 -31.359 1.00 15.27 ? 276 THR A CB 1 ATOM 2024 O OG1 . THR A 1 292 ? -17.613 11.451 -31.440 1.00 16.50 ? 276 THR A OG1 1 ATOM 2025 C CG2 . THR A 1 292 ? -19.389 10.413 -32.696 1.00 17.82 ? 276 THR A CG2 1 ATOM 2026 N N . THR A 1 293 ? -21.878 10.021 -30.622 1.00 11.06 ? 277 THR A N 1 ATOM 2027 C CA . THR A 1 293 ? -22.953 9.040 -30.585 1.00 10.01 ? 277 THR A CA 1 ATOM 2028 C C . THR A 1 293 ? -23.455 8.774 -32.000 1.00 11.80 ? 277 THR A C 1 ATOM 2029 O O . THR A 1 293 ? -23.889 9.691 -32.695 1.00 14.54 ? 277 THR A O 1 ATOM 2030 C CB . THR A 1 293 ? -24.127 9.532 -29.728 1.00 9.86 ? 277 THR A CB 1 ATOM 2031 O OG1 . THR A 1 293 ? -23.641 10.012 -28.468 1.00 16.79 ? 277 THR A OG1 1 ATOM 2032 C CG2 . THR A 1 293 ? -25.115 8.408 -29.491 1.00 12.59 ? 277 THR A CG2 1 ATOM 2033 N N . ILE A 1 294 ? -23.399 7.515 -32.422 1.00 15.79 ? 278 ILE A N 1 ATOM 2034 C CA . ILE A 1 294 ? -23.792 7.144 -33.776 1.00 17.07 ? 278 ILE A CA 1 ATOM 2035 C C . ILE A 1 294 ? -25.285 6.844 -33.860 1.00 15.29 ? 278 ILE A C 1 ATOM 2036 O O . ILE A 1 294 ? -25.834 6.137 -33.016 1.00 16.42 ? 278 ILE A O 1 ATOM 2037 C CB . ILE A 1 294 ? -23.013 5.908 -34.258 1.00 19.33 ? 278 ILE A CB 1 ATOM 2038 C CG1 . ILE A 1 294 ? -21.513 6.210 -34.305 1.00 17.67 ? 278 ILE A CG1 1 ATOM 2039 C CG2 . ILE A 1 294 ? -23.510 5.471 -35.628 1.00 22.45 ? 278 ILE A CG2 1 ATOM 2040 C CD1 . ILE A 1 294 ? -21.076 6.942 -35.549 1.00 20.61 ? 278 ILE A CD1 1 ATOM 2041 N N . PHE A 1 295 ? -25.931 7.385 -34.888 1.00 14.87 ? 279 PHE A N 1 ATOM 2042 C CA . PHE A 1 295 ? -27.349 7.145 -35.127 1.00 12.60 ? 279 PHE A CA 1 ATOM 2043 C C . PHE A 1 295 ? -27.558 6.519 -36.499 1.00 17.26 ? 279 PHE A C 1 ATOM 2044 O O . PHE A 1 295 ? -26.663 6.535 -37.344 1.00 19.37 ? 279 PHE A O 1 ATOM 2045 C CB . PHE A 1 295 ? -28.132 8.458 -35.055 1.00 17.61 ? 279 PHE A CB 1 ATOM 2046 C CG . PHE A 1 295 ? -28.267 9.011 -33.668 1.00 14.50 ? 279 PHE A CG 1 ATOM 2047 C CD1 . PHE A 1 295 ? -27.205 9.655 -33.058 1.00 17.07 ? 279 PHE A CD1 1 ATOM 2048 C CD2 . PHE A 1 295 ? -29.461 8.898 -32.978 1.00 17.86 ? 279 PHE A CD2 1 ATOM 2049 C CE1 . PHE A 1 295 ? -27.328 10.167 -31.782 1.00 16.33 ? 279 PHE A CE1 1 ATOM 2050 C CE2 . PHE A 1 295 ? -29.592 9.410 -31.703 1.00 22.86 ? 279 PHE A CE2 1 ATOM 2051 C CZ . PHE A 1 295 ? -28.524 10.045 -31.104 1.00 20.29 ? 279 PHE A CZ 1 ATOM 2052 N N . ALA A 1 296 ? -28.747 5.964 -36.715 1.00 20.95 ? 280 ALA A N 1 ATOM 2053 C CA . ALA A 1 296 ? -29.140 5.480 -38.032 1.00 14.49 ? 280 ALA A CA 1 ATOM 2054 C C . ALA A 1 296 ? -29.918 6.587 -38.732 1.00 14.02 ? 280 ALA A C 1 ATOM 2055 O O . ALA A 1 296 ? -31.146 6.638 -38.665 1.00 24.55 ? 280 ALA A O 1 ATOM 2056 C CB . ALA A 1 296 ? -29.986 4.223 -37.906 1.00 20.36 ? 280 ALA A CB 1 ATOM 2057 N N . GLY A 1 297 ? -29.191 7.478 -39.398 1.00 17.64 ? 281 GLY A N 1 ATOM 2058 C CA . GLY A 1 297 ? -29.765 8.713 -39.898 1.00 13.47 ? 281 GLY A CA 1 ATOM 2059 C C . GLY A 1 297 ? -30.654 8.576 -41.116 1.00 14.25 ? 281 GLY A C 1 ATOM 2060 O O . GLY A 1 297 ? -30.696 7.536 -41.775 1.00 16.25 ? 281 GLY A O 1 ATOM 2061 N N . HIS A 1 298 ? -31.372 9.653 -41.409 1.00 14.83 ? 282 HIS A N 1 ATOM 2062 C CA . HIS A 1 298 ? -32.280 9.696 -42.544 1.00 17.76 ? 282 HIS A CA 1 ATOM 2063 C C . HIS A 1 298 ? -32.301 11.105 -43.141 1.00 11.62 ? 282 HIS A C 1 ATOM 2064 O O . HIS A 1 298 ? -32.585 12.077 -42.441 1.00 12.78 ? 282 HIS A O 1 ATOM 2065 C CB . HIS A 1 298 ? -33.689 9.291 -42.107 1.00 17.74 ? 282 HIS A CB 1 ATOM 2066 C CG . HIS A 1 298 ? -33.783 7.896 -41.570 1.00 22.99 ? 282 HIS A CG 1 ATOM 2067 N ND1 . HIS A 1 298 ? -33.442 6.788 -42.315 1.00 31.20 ? 282 HIS A ND1 1 ATOM 2068 C CD2 . HIS A 1 298 ? -34.197 7.426 -40.368 1.00 26.06 ? 282 HIS A CD2 1 ATOM 2069 C CE1 . HIS A 1 298 ? -33.633 5.698 -41.595 1.00 30.53 ? 282 HIS A CE1 1 ATOM 2070 N NE2 . HIS A 1 298 ? -34.091 6.056 -40.409 1.00 26.50 ? 282 HIS A NE2 1 ATOM 2071 N N . LEU A 1 299 ? -32.003 11.210 -44.433 1.00 9.84 ? 283 LEU A N 1 ATOM 2072 C CA . LEU A 1 299 ? -31.906 12.507 -45.100 1.00 9.03 ? 283 LEU A CA 1 ATOM 2073 C C . LEU A 1 299 ? -32.838 12.618 -46.303 1.00 8.05 ? 283 LEU A C 1 ATOM 2074 O O . LEU A 1 299 ? -33.005 11.662 -47.061 1.00 9.36 ? 283 LEU A O 1 ATOM 2075 C CB . LEU A 1 299 ? -30.469 12.751 -45.574 1.00 8.62 ? 283 LEU A CB 1 ATOM 2076 C CG . LEU A 1 299 ? -29.451 13.258 -44.553 1.00 5.96 ? 283 LEU A CG 1 ATOM 2077 C CD1 . LEU A 1 299 ? -28.086 13.350 -45.206 1.00 12.21 ? 283 LEU A CD1 1 ATOM 2078 C CD2 . LEU A 1 299 ? -29.860 14.609 -43.991 1.00 5.74 ? 283 LEU A CD2 1 ATOM 2079 N N . LYS A 1 300 ? -33.443 13.791 -46.469 1.00 9.16 ? 284 LYS A N 1 ATOM 2080 C CA . LYS A 1 300 ? -34.114 14.137 -47.716 1.00 5.78 ? 284 LYS A CA 1 ATOM 2081 C C . LYS A 1 300 ? -33.282 15.209 -48.404 1.00 9.59 ? 284 LYS A C 1 ATOM 2082 O O . LYS A 1 300 ? -32.986 16.245 -47.807 1.00 10.86 ? 284 LYS A O 1 ATOM 2083 C CB . LYS A 1 300 ? -35.530 14.651 -47.464 1.00 6.92 ? 284 LYS A CB 1 ATOM 2084 C CG . LYS A 1 300 ? -36.342 14.808 -48.741 1.00 14.28 ? 284 LYS A CG 1 ATOM 2085 C CD . LYS A 1 300 ? -37.698 15.442 -48.485 1.00 27.64 ? 284 LYS A CD 1 ATOM 2086 C CE . LYS A 1 300 ? -38.569 15.400 -49.733 1.00 51.74 ? 284 LYS A CE 1 ATOM 2087 N NZ . LYS A 1 300 ? -38.991 14.014 -50.083 1.00 32.62 ? 284 LYS A NZ 1 ATOM 2088 N N . CYS A 1 301 ? -32.907 14.964 -49.655 1.00 9.02 ? 285 CYS A N 1 ATOM 2089 C CA . CYS A 1 301 ? -31.945 15.821 -50.334 1.00 8.60 ? 285 CYS A CA 1 ATOM 2090 C C . CYS A 1 301 ? -32.451 16.354 -51.668 1.00 8.32 ? 285 CYS A C 1 ATOM 2091 O O . CYS A 1 301 ? -33.140 15.655 -52.413 1.00 14.98 ? 285 CYS A O 1 ATOM 2092 C CB . CYS A 1 301 ? -30.639 15.055 -50.562 1.00 3.64 ? 285 CYS A CB 1 ATOM 2093 S SG . CYS A 1 301 ? -29.835 14.491 -49.053 1.00 9.57 ? 285 CYS A SG 1 ATOM 2094 N N . ARG A 1 302 ? -32.098 17.603 -51.957 1.00 5.54 ? 286 ARG A N 1 ATOM 2095 C CA . ARG A 1 302 ? -32.339 18.192 -53.265 1.00 7.29 ? 286 ARG A CA 1 ATOM 2096 C C . ARG A 1 302 ? -31.015 18.339 -54.006 1.00 11.29 ? 286 ARG A C 1 ATOM 2097 O O . ARG A 1 302 ? -30.129 19.076 -53.573 1.00 7.68 ? 286 ARG A O 1 ATOM 2098 C CB . ARG A 1 302 ? -33.012 19.558 -53.128 1.00 5.50 ? 286 ARG A CB 1 ATOM 2099 C CG . ARG A 1 302 ? -32.928 20.418 -54.381 1.00 5.05 ? 286 ARG A CG 1 ATOM 2100 C CD . ARG A 1 302 ? -33.537 19.722 -55.588 1.00 8.06 ? 286 ARG A CD 1 ATOM 2101 N NE . ARG A 1 302 ? -34.928 19.346 -55.356 1.00 8.15 ? 286 ARG A NE 1 ATOM 2102 C CZ . ARG A 1 302 ? -35.951 20.195 -55.384 1.00 6.73 ? 286 ARG A CZ 1 ATOM 2103 N NH1 . ARG A 1 302 ? -35.753 21.483 -55.625 1.00 7.58 ? 286 ARG A NH1 1 ATOM 2104 N NH2 . ARG A 1 302 ? -37.180 19.756 -55.158 1.00 7.36 ? 286 ARG A NH2 1 ATOM 2105 N N . LEU A 1 303 ? -30.883 17.629 -55.120 1.00 9.44 ? 287 LEU A N 1 ATOM 2106 C CA . LEU A 1 303 ? -29.685 17.711 -55.944 1.00 6.88 ? 287 LEU A CA 1 ATOM 2107 C C . LEU A 1 303 ? -29.864 18.761 -57.032 1.00 5.57 ? 287 LEU A C 1 ATOM 2108 O O . LEU A 1 303 ? -30.817 18.701 -57.809 1.00 6.45 ? 287 LEU A O 1 ATOM 2109 C CB . LEU A 1 303 ? -29.390 16.352 -56.581 1.00 5.58 ? 287 LEU A CB 1 ATOM 2110 C CG . LEU A 1 303 ? -28.632 15.325 -55.739 1.00 7.66 ? 287 LEU A CG 1 ATOM 2111 C CD1 . LEU A 1 303 ? -29.106 15.329 -54.296 1.00 7.61 ? 287 LEU A CD1 1 ATOM 2112 C CD2 . LEU A 1 303 ? -28.799 13.946 -56.352 1.00 6.57 ? 287 LEU A CD2 1 ATOM 2113 N N . LYS A 1 304 ? -28.953 19.727 -57.080 1.00 5.99 ? 288 LYS A N 1 ATOM 2114 C CA . LYS A 1 304 ? -28.984 20.744 -58.122 1.00 5.96 ? 288 LYS A CA 1 ATOM 2115 C C . LYS A 1 304 ? -27.783 20.597 -59.046 1.00 9.90 ? 288 LYS A C 1 ATOM 2116 O O . LYS A 1 304 ? -26.634 20.667 -58.610 1.00 12.95 ? 288 LYS A O 1 ATOM 2117 C CB . LYS A 1 304 ? -28.996 22.149 -57.520 1.00 6.28 ? 288 LYS A CB 1 ATOM 2118 C CG . LYS A 1 304 ? -30.043 22.368 -56.444 1.00 5.80 ? 288 LYS A CG 1 ATOM 2119 C CD . LYS A 1 304 ? -30.067 23.820 -56.006 1.00 5.03 ? 288 LYS A CD 1 ATOM 2120 C CE . LYS A 1 304 ? -31.173 24.080 -55.003 1.00 11.96 ? 288 LYS A CE 1 ATOM 2121 N NZ . LYS A 1 304 ? -31.201 25.505 -54.576 1.00 19.73 ? 288 LYS A NZ 1 ATOM 2122 N N . MET A 1 305 ? -28.061 20.390 -60.326 1.00 8.87 ? 289 MET A N 1 ATOM 2123 C CA . MET A 1 305 ? -27.022 20.312 -61.341 1.00 9.29 ? 289 MET A CA 1 ATOM 2124 C C . MET A 1 305 ? -27.497 21.060 -62.576 1.00 10.94 ? 289 MET A C 1 ATOM 2125 O O . MET A 1 305 ? -28.673 21.404 -62.683 1.00 15.10 ? 289 MET A O 1 ATOM 2126 C CB . MET A 1 305 ? -26.707 18.854 -61.680 1.00 7.98 ? 289 MET A CB 1 ATOM 2127 C CG . MET A 1 305 ? -27.935 17.979 -61.852 1.00 13.18 ? 289 MET A CG 1 ATOM 2128 S SD . MET A 1 305 ? -27.528 16.234 -62.057 1.00 24.30 ? 289 MET A SD 1 ATOM 2129 C CE . MET A 1 305 ? -28.280 15.543 -60.586 1.00 7.30 ? 289 MET A CE 1 ATOM 2130 N N . ASP A 1 306 ? -26.585 21.318 -63.506 1.00 12.49 ? 290 ASP A N 1 ATOM 2131 C CA . ASP A 1 306 ? -26.918 22.089 -64.696 1.00 15.15 ? 290 ASP A CA 1 ATOM 2132 C C . ASP A 1 306 ? -27.944 21.351 -65.547 1.00 10.67 ? 290 ASP A C 1 ATOM 2133 O O . ASP A 1 306 ? -28.074 20.129 -65.462 1.00 13.06 ? 290 ASP A O 1 ATOM 2134 C CB . ASP A 1 306 ? -25.662 22.380 -65.518 1.00 17.69 ? 290 ASP A CB 1 ATOM 2135 C CG . ASP A 1 306 ? -24.689 23.289 -64.793 1.00 28.12 ? 290 ASP A CG 1 ATOM 2136 O OD1 . ASP A 1 306 ? -23.816 22.769 -64.067 1.00 29.04 ? 290 ASP A OD1 1 ATOM 2137 O OD2 . ASP A 1 306 ? -24.800 24.524 -64.948 1.00 22.98 ? 290 ASP A OD2 1 ATOM 2138 N N . LYS A 1 307 ? -28.674 22.107 -66.359 1.00 13.44 ? 291 LYS A N 1 ATOM 2139 C CA . LYS A 1 307 ? -29.688 21.546 -67.243 1.00 9.34 ? 291 LYS A CA 1 ATOM 2140 C C . LYS A 1 307 ? -29.177 20.259 -67.882 1.00 7.02 ? 291 LYS A C 1 ATOM 2141 O O . LYS A 1 307 ? -28.156 20.259 -68.569 1.00 11.50 ? 291 LYS A O 1 ATOM 2142 C CB . LYS A 1 307 ? -30.049 22.561 -68.326 1.00 7.75 ? 291 LYS A CB 1 ATOM 2143 C CG . LYS A 1 307 ? -31.419 22.358 -68.937 1.00 5.58 ? 291 LYS A CG 1 ATOM 2144 C CD . LYS A 1 307 ? -31.704 23.411 -69.994 1.00 5.77 ? 291 LYS A CD 1 ATOM 2145 C CE . LYS A 1 307 ? -32.021 22.781 -71.335 1.00 7.50 ? 291 LYS A CE 1 ATOM 2146 N NZ . LYS A 1 307 ? -33.283 21.995 -71.307 1.00 15.18 ? 291 LYS A NZ 1 ATOM 2147 N N . LEU A 1 308 ? -29.893 19.162 -67.653 1.00 8.53 ? 292 LEU A N 1 ATOM 2148 C CA . LEU A 1 308 ? -29.443 17.848 -68.099 1.00 5.34 ? 292 LEU A CA 1 ATOM 2149 C C . LEU A 1 308 ? -30.599 16.850 -68.126 1.00 8.91 ? 292 LEU A C 1 ATOM 2150 O O . LEU A 1 308 ? -31.423 16.816 -67.211 1.00 15.33 ? 292 LEU A O 1 ATOM 2151 C CB . LEU A 1 308 ? -28.338 17.342 -67.170 1.00 13.37 ? 292 LEU A CB 1 ATOM 2152 C CG . LEU A 1 308 ? -27.752 15.961 -67.459 1.00 14.24 ? 292 LEU A CG 1 ATOM 2153 C CD1 . LEU A 1 308 ? -27.108 15.924 -68.836 1.00 24.47 ? 292 LEU A CD1 1 ATOM 2154 C CD2 . LEU A 1 308 ? -26.745 15.594 -66.378 1.00 20.90 ? 292 LEU A CD2 1 ATOM 2155 N N . THR A 1 309 ? -30.652 16.039 -69.178 1.00 6.53 ? 293 THR A N 1 ATOM 2156 C CA . THR A 1 309 ? -31.714 15.055 -69.336 1.00 6.50 ? 293 THR A CA 1 ATOM 2157 C C . THR A 1 309 ? -31.323 13.748 -68.657 1.00 10.18 ? 293 THR A C 1 ATOM 2158 O O . THR A 1 309 ? -30.439 13.033 -69.129 1.00 16.71 ? 293 THR A O 1 ATOM 2159 C CB . THR A 1 309 ? -31.991 14.768 -70.822 1.00 6.54 ? 293 THR A CB 1 ATOM 2160 O OG1 . THR A 1 309 ? -32.097 16.001 -71.544 1.00 19.20 ? 293 THR A OG1 1 ATOM 2161 C CG2 . THR A 1 309 ? -33.275 13.968 -70.995 1.00 9.47 ? 293 THR A CG2 1 ATOM 2162 N N . LEU A 1 310 ? -31.983 13.440 -67.545 1.00 10.45 ? 294 LEU A N 1 ATOM 2163 C CA . LEU A 1 310 ? -31.684 12.230 -66.790 1.00 6.93 ? 294 LEU A CA 1 ATOM 2164 C C . LEU A 1 310 ? -32.469 11.031 -67.312 1.00 11.22 ? 294 LEU A C 1 ATOM 2165 O O . LEU A 1 310 ? -33.501 11.184 -67.967 1.00 12.47 ? 294 LEU A O 1 ATOM 2166 C CB . LEU A 1 310 ? -31.998 12.436 -65.307 1.00 5.99 ? 294 LEU A CB 1 ATOM 2167 C CG . LEU A 1 310 ? -31.154 13.472 -64.562 1.00 3.55 ? 294 LEU A CG 1 ATOM 2168 C CD1 . LEU A 1 310 ? -31.582 13.548 -63.104 1.00 4.35 ? 294 LEU A CD1 1 ATOM 2169 C CD2 . LEU A 1 310 ? -29.673 13.147 -64.668 1.00 5.85 ? 294 LEU A CD2 1 ATOM 2170 N N . LYS A 1 311 ? -31.968 9.838 -67.011 1.00 16.65 ? 295 LYS A N 1 ATOM 2171 C CA . LYS A 1 311 ? -32.635 8.597 -67.383 1.00 13.91 ? 295 LYS A CA 1 ATOM 2172 C C . LYS A 1 311 ? -33.368 8.025 -66.177 1.00 14.89 ? 295 LYS A C 1 ATOM 2173 O O . LYS A 1 311 ? -32.769 7.357 -65.334 1.00 19.32 ? 295 LYS A O 1 ATOM 2174 C CB . LYS A 1 311 ? -31.616 7.578 -67.894 1.00 21.59 ? 295 LYS A CB 1 ATOM 2175 C CG . LYS A 1 311 ? -32.214 6.228 -68.262 1.00 26.01 ? 295 LYS A CG 1 ATOM 2176 C CD . LYS A 1 311 ? -31.176 5.119 -68.197 1.00 39.50 ? 295 LYS A CD 1 ATOM 2177 C CE . LYS A 1 311 ? -30.800 4.789 -66.759 1.00 34.31 ? 295 LYS A CE 1 ATOM 2178 N NZ . LYS A 1 311 ? -29.763 3.725 -66.673 1.00 41.39 ? 295 LYS A NZ 1 ATOM 2179 N N . GLY A 1 312 ? -34.667 8.289 -66.098 1.00 15.26 ? 296 GLY A N 1 ATOM 2180 C CA . GLY A 1 312 ? -35.472 7.801 -64.995 1.00 11.26 ? 296 GLY A CA 1 ATOM 2181 C C . GLY A 1 312 ? -35.540 6.286 -64.978 1.00 17.25 ? 296 GLY A C 1 ATOM 2182 O O . GLY A 1 312 ? -35.483 5.642 -66.026 1.00 20.78 ? 296 GLY A O 1 ATOM 2183 N N . MET A 1 313 ? -35.663 5.718 -63.782 1.00 16.03 ? 297 MET A N 1 ATOM 2184 C CA . MET A 1 313 ? -35.721 4.269 -63.615 1.00 13.21 ? 297 MET A CA 1 ATOM 2185 C C . MET A 1 313 ? -37.085 3.844 -63.082 1.00 11.29 ? 297 MET A C 1 ATOM 2186 O O . MET A 1 313 ? -37.541 4.339 -62.051 1.00 15.05 ? 297 MET A O 1 ATOM 2187 C CB . MET A 1 313 ? -34.624 3.802 -62.656 1.00 13.81 ? 297 MET A CB 1 ATOM 2188 C CG . MET A 1 313 ? -34.659 2.314 -62.350 1.00 13.99 ? 297 MET A CG 1 ATOM 2189 S SD . MET A 1 313 ? -34.362 1.290 -63.802 1.00 30.05 ? 297 MET A SD 1 ATOM 2190 C CE . MET A 1 313 ? -34.597 -0.344 -63.109 1.00 14.17 ? 297 MET A CE 1 ATOM 2191 N N . SER A 1 314 ? -37.729 2.923 -63.792 1.00 17.36 ? 298 SER A N 1 ATOM 2192 C CA . SER A 1 314 ? -39.040 2.421 -63.397 1.00 17.77 ? 298 SER A CA 1 ATOM 2193 C C . SER A 1 314 ? -38.937 1.024 -62.796 1.00 14.17 ? 298 SER A C 1 ATOM 2194 O O . SER A 1 314 ? -38.072 0.235 -63.179 1.00 16.19 ? 298 SER A O 1 ATOM 2195 C CB . SER A 1 314 ? -39.976 2.389 -64.605 1.00 21.89 ? 298 SER A CB 1 ATOM 2196 O OG . SER A 1 314 ? -40.241 3.696 -65.084 1.00 38.62 ? 298 SER A OG 1 ATOM 2197 N N . TYR A 1 315 ? -39.830 0.724 -61.858 1.00 13.28 ? 299 TYR A N 1 ATOM 2198 C CA . TYR A 1 315 ? -39.871 -0.587 -61.222 1.00 13.53 ? 299 TYR A CA 1 ATOM 2199 C C . TYR A 1 315 ? -41.299 -1.116 -61.186 1.00 16.93 ? 299 TYR A C 1 ATOM 2200 O O . TYR A 1 315 ? -42.191 -0.477 -60.627 1.00 21.33 ? 299 TYR A O 1 ATOM 2201 C CB . TYR A 1 315 ? -39.327 -0.514 -59.794 1.00 10.78 ? 299 TYR A CB 1 ATOM 2202 C CG . TYR A 1 315 ? -37.862 -0.159 -59.699 1.00 9.56 ? 299 TYR A CG 1 ATOM 2203 C CD1 . TYR A 1 315 ? -36.882 -1.127 -59.863 1.00 8.69 ? 299 TYR A CD1 1 ATOM 2204 C CD2 . TYR A 1 315 ? -37.460 1.141 -59.430 1.00 10.46 ? 299 TYR A CD2 1 ATOM 2205 C CE1 . TYR A 1 315 ? -35.542 -0.809 -59.771 1.00 7.26 ? 299 TYR A CE1 1 ATOM 2206 C CE2 . TYR A 1 315 ? -36.121 1.469 -59.335 1.00 9.01 ? 299 TYR A CE2 1 ATOM 2207 C CZ . TYR A 1 315 ? -35.167 0.489 -59.508 1.00 7.09 ? 299 TYR A CZ 1 ATOM 2208 O OH . TYR A 1 315 ? -33.832 0.801 -59.415 1.00 9.09 ? 299 TYR A OH 1 ATOM 2209 N N . VAL A 1 316 ? -41.508 -2.284 -61.784 1.00 15.47 ? 300 VAL A N 1 ATOM 2210 C CA . VAL A 1 316 ? -42.806 -2.948 -61.730 1.00 15.17 ? 300 VAL A CA 1 ATOM 2211 C C . VAL A 1 316 ? -43.039 -3.535 -60.345 1.00 13.36 ? 300 VAL A C 1 ATOM 2212 O O . VAL A 1 316 ? -42.096 -3.952 -59.674 1.00 11.28 ? 300 VAL A O 1 ATOM 2213 C CB . VAL A 1 316 ? -42.923 -4.084 -62.773 1.00 24.00 ? 300 VAL A CB 1 ATOM 2214 C CG1 . VAL A 1 316 ? -42.897 -3.521 -64.187 1.00 21.08 ? 300 VAL A CG1 1 ATOM 2215 C CG2 . VAL A 1 316 ? -41.825 -5.132 -62.574 1.00 19.34 ? 300 VAL A CG2 1 ATOM 2216 N N . MET A 1 317 ? -44.297 -3.566 -59.920 1.00 14.94 ? 301 MET A N 1 ATOM 2217 C CA . MET A 1 317 ? -44.648 -4.145 -58.631 1.00 15.21 ? 301 MET A CA 1 ATOM 2218 C C . MET A 1 317 ? -44.258 -5.617 -58.600 1.00 14.46 ? 301 MET A C 1 ATOM 2219 O O . MET A 1 317 ? -44.481 -6.345 -59.566 1.00 15.88 ? 301 MET A O 1 ATOM 2220 C CB . MET A 1 317 ? -46.150 -4.009 -58.371 1.00 16.22 ? 301 MET A CB 1 ATOM 2221 C CG . MET A 1 317 ? -46.657 -2.576 -58.317 1.00 12.61 ? 301 MET A CG 1 ATOM 2222 S SD . MET A 1 317 ? -45.787 -1.556 -57.112 1.00 32.95 ? 301 MET A SD 1 ATOM 2223 C CE . MET A 1 317 ? -46.095 -2.462 -55.601 1.00 16.07 ? 301 MET A CE 1 ATOM 2224 N N . CYS A 1 318 ? -43.671 -6.051 -57.490 1.00 13.63 ? 302 CYS A N 1 ATOM 2225 C CA . CYS A 1 318 ? -43.314 -7.453 -57.320 1.00 12.67 ? 302 CYS A CA 1 ATOM 2226 C C . CYS A 1 318 ? -44.567 -8.314 -57.433 1.00 12.71 ? 302 CYS A C 1 ATOM 2227 O O . CYS A 1 318 ? -45.658 -7.883 -57.059 1.00 14.74 ? 302 CYS A O 1 ATOM 2228 C CB . CYS A 1 318 ? -42.644 -7.676 -55.963 1.00 12.35 ? 302 CYS A CB 1 ATOM 2229 S SG . CYS A 1 318 ? -41.110 -6.754 -55.729 1.00 18.01 ? 302 CYS A SG 1 ATOM 2230 N N . THR A 1 319 ? -44.406 -9.527 -57.952 1.00 18.47 ? 303 THR A N 1 ATOM 2231 C CA . THR A 1 319 ? -45.532 -10.437 -58.136 1.00 14.30 ? 303 THR A CA 1 ATOM 2232 C C . THR A 1 319 ? -45.404 -11.692 -57.276 1.00 15.35 ? 303 THR A C 1 ATOM 2233 O O . THR A 1 319 ? -46.380 -12.415 -57.076 1.00 18.66 ? 303 THR A O 1 ATOM 2234 C CB . THR A 1 319 ? -45.665 -10.870 -59.610 1.00 10.31 ? 303 THR A CB 1 ATOM 2235 O OG1 . THR A 1 319 ? -44.567 -11.718 -59.969 1.00 14.72 ? 303 THR A OG1 1 ATOM 2236 C CG2 . THR A 1 319 ? -45.694 -9.653 -60.527 1.00 7.74 ? 303 THR A CG2 1 ATOM 2237 N N . GLY A 1 320 ? -44.204 -11.945 -56.764 1.00 11.16 ? 304 GLY A N 1 ATOM 2238 C CA . GLY A 1 320 ? -43.943 -13.145 -55.990 1.00 13.67 ? 304 GLY A CA 1 ATOM 2239 C C . GLY A 1 320 ? -44.261 -12.984 -54.516 1.00 15.68 ? 304 GLY A C 1 ATOM 2240 O O . GLY A 1 320 ? -45.041 -12.109 -54.132 1.00 12.87 ? 304 GLY A O 1 ATOM 2241 N N . SER A 1 321 ? -43.637 -13.825 -53.694 1.00 14.36 ? 305 SER A N 1 ATOM 2242 C CA . SER A 1 321 ? -43.903 -13.854 -52.258 1.00 12.12 ? 305 SER A CA 1 ATOM 2243 C C . SER A 1 321 ? -42.764 -13.253 -51.444 1.00 13.72 ? 305 SER A C 1 ATOM 2244 O O . SER A 1 321 ? -41.633 -13.144 -51.917 1.00 12.44 ? 305 SER A O 1 ATOM 2245 C CB . SER A 1 321 ? -44.185 -15.283 -51.758 1.00 19.88 ? 305 SER A CB 1 ATOM 2246 O OG . SER A 1 321 ? -43.341 -16.271 -52.332 1.00 37.65 ? 305 SER A OG 1 ATOM 2247 N N . PHE A 1 322 ? -43.079 -12.878 -50.208 1.00 13.73 ? 306 PHE A N 1 ATOM 2248 C CA . PHE A 1 322 ? -42.092 -12.324 -49.290 1.00 10.13 ? 306 PHE A CA 1 ATOM 2249 C C . PHE A 1 322 ? -42.065 -13.129 -47.997 1.00 11.75 ? 306 PHE A C 1 ATOM 2250 O O . PHE A 1 322 ? -43.106 -13.564 -47.505 1.00 11.20 ? 306 PHE A O 1 ATOM 2251 C CB . PHE A 1 322 ? -42.413 -10.860 -48.975 1.00 8.46 ? 306 PHE A CB 1 ATOM 2252 C CG . PHE A 1 322 ? -42.284 -9.941 -50.156 1.00 8.21 ? 306 PHE A CG 1 ATOM 2253 C CD1 . PHE A 1 322 ? -43.345 -9.756 -51.025 1.00 8.80 ? 306 PHE A CD1 1 ATOM 2254 C CD2 . PHE A 1 322 ? -41.105 -9.255 -50.392 1.00 10.12 ? 306 PHE A CD2 1 ATOM 2255 C CE1 . PHE A 1 322 ? -43.230 -8.912 -52.112 1.00 8.75 ? 306 PHE A CE1 1 ATOM 2256 C CE2 . PHE A 1 322 ? -40.983 -8.410 -51.477 1.00 13.78 ? 306 PHE A CE2 1 ATOM 2257 C CZ . PHE A 1 322 ? -42.048 -8.236 -52.337 1.00 13.00 ? 306 PHE A CZ 1 ATOM 2258 N N . LYS A 1 323 ? -40.866 -13.336 -47.461 1.00 17.85 ? 307 LYS A N 1 ATOM 2259 C CA . LYS A 1 323 ? -40.704 -13.990 -46.168 1.00 16.44 ? 307 LYS A CA 1 ATOM 2260 C C . LYS A 1 323 ? -40.057 -13.046 -45.164 1.00 19.17 ? 307 LYS A C 1 ATOM 2261 O O . LYS A 1 323 ? -39.138 -12.300 -45.500 1.00 14.26 ? 307 LYS A O 1 ATOM 2262 C CB . LYS A 1 323 ? -39.854 -15.253 -46.299 1.00 23.19 ? 307 LYS A CB 1 ATOM 2263 C CG . LYS A 1 323 ? -40.664 -16.527 -46.464 1.00 38.57 ? 307 LYS A CG 1 ATOM 2264 C CD . LYS A 1 323 ? -39.842 -17.757 -46.112 1.00 55.97 ? 307 LYS A CD 1 ATOM 2265 C CE . LYS A 1 323 ? -40.725 -18.977 -45.910 1.00 52.55 ? 307 LYS A CE 1 ATOM 2266 N NZ . LYS A 1 323 ? -39.993 -20.081 -45.230 1.00 44.30 ? 307 LYS A NZ 1 ATOM 2267 N N . LEU A 1 324 ? -40.539 -13.091 -43.928 1.00 18.55 ? 308 LEU A N 1 ATOM 2268 C CA . LEU A 1 324 ? -40.009 -12.243 -42.870 1.00 12.34 ? 308 LEU A CA 1 ATOM 2269 C C . LEU A 1 324 ? -38.671 -12.785 -42.390 1.00 18.06 ? 308 LEU A C 1 ATOM 2270 O O . LEU A 1 324 ? -38.619 -13.727 -41.598 1.00 23.85 ? 308 LEU A O 1 ATOM 2271 C CB . LEU A 1 324 ? -40.995 -12.169 -41.704 1.00 16.37 ? 308 LEU A CB 1 ATOM 2272 C CG . LEU A 1 324 ? -41.397 -10.764 -41.258 1.00 22.57 ? 308 LEU A CG 1 ATOM 2273 C CD1 . LEU A 1 324 ? -42.127 -10.031 -42.369 1.00 21.71 ? 308 LEU A CD1 1 ATOM 2274 C CD2 . LEU A 1 324 ? -42.258 -10.853 -40.025 1.00 18.45 ? 308 LEU A CD2 1 ATOM 2275 N N . GLU A 1 325 ? -37.589 -12.186 -42.873 1.00 17.40 ? 309 GLU A N 1 ATOM 2276 C CA . GLU A 1 325 ? -36.250 -12.633 -42.512 1.00 22.54 ? 309 GLU A CA 1 ATOM 2277 C C . GLU A 1 325 ? -36.060 -12.587 -40.998 1.00 18.97 ? 309 GLU A C 1 ATOM 2278 O O . GLU A 1 325 ? -35.357 -13.422 -40.430 1.00 21.49 ? 309 GLU A O 1 ATOM 2279 C CB . GLU A 1 325 ? -35.188 -11.780 -43.208 1.00 18.46 ? 309 GLU A CB 1 ATOM 2280 C CG . GLU A 1 325 ? -33.774 -12.340 -43.104 1.00 25.57 ? 309 GLU A CG 1 ATOM 2281 C CD . GLU A 1 325 ? -33.595 -13.643 -43.865 1.00 25.94 ? 309 GLU A CD 1 ATOM 2282 O OE1 . GLU A 1 325 ? -34.566 -14.105 -44.500 1.00 23.00 ? 309 GLU A OE1 1 ATOM 2283 O OE2 . GLU A 1 325 ? -32.479 -14.205 -43.828 1.00 22.59 ? 309 GLU A OE2 1 ATOM 2284 N N . LYS A 1 326 ? -36.694 -11.619 -40.343 1.00 15.84 ? 310 LYS A N 1 ATOM 2285 C CA . LYS A 1 326 ? -36.639 -11.542 -38.887 1.00 21.27 ? 310 LYS A CA 1 ATOM 2286 C C . LYS A 1 326 ? -37.858 -10.830 -38.304 1.00 19.40 ? 310 LYS A C 1 ATOM 2287 O O . LYS A 1 326 ? -38.686 -10.284 -39.034 1.00 24.06 ? 310 LYS A O 1 ATOM 2288 C CB . LYS A 1 326 ? -35.341 -10.875 -38.423 1.00 27.03 ? 310 LYS A CB 1 ATOM 2289 C CG . LYS A 1 326 ? -35.136 -9.450 -38.903 1.00 24.75 ? 310 LYS A CG 1 ATOM 2290 C CD . LYS A 1 326 ? -33.711 -8.999 -38.611 1.00 27.94 ? 310 LYS A CD 1 ATOM 2291 C CE . LYS A 1 326 ? -33.578 -7.487 -38.590 1.00 40.34 ? 310 LYS A CE 1 ATOM 2292 N NZ . LYS A 1 326 ? -32.200 -7.081 -38.197 1.00 39.20 ? 310 LYS A NZ 1 ATOM 2293 N N . GLU A 1 327 ? -37.954 -10.850 -36.980 1.00 16.69 ? 311 GLU A N 1 ATOM 2294 C CA . GLU A 1 327 ? -39.140 -10.382 -36.273 1.00 22.01 ? 311 GLU A CA 1 ATOM 2295 C C . GLU A 1 327 ? -39.373 -8.882 -36.432 1.00 19.86 ? 311 GLU A C 1 ATOM 2296 O O . GLU A 1 327 ? -38.426 -8.098 -36.499 1.00 18.02 ? 311 GLU A O 1 ATOM 2297 C CB . GLU A 1 327 ? -39.010 -10.720 -34.789 1.00 18.09 ? 311 GLU A CB 1 ATOM 2298 C CG . GLU A 1 327 ? -40.291 -10.555 -33.995 1.00 19.10 ? 311 GLU A CG 1 ATOM 2299 C CD . GLU A 1 327 ? -41.449 -11.317 -34.601 1.00 15.62 ? 311 GLU A CD 1 ATOM 2300 O OE1 . GLU A 1 327 ? -41.508 -12.552 -34.429 1.00 13.15 ? 311 GLU A OE1 1 ATOM 2301 O OE2 . GLU A 1 327 ? -42.298 -10.679 -35.256 1.00 18.01 ? 311 GLU A OE2 1 ATOM 2302 N N . VAL A 1 328 ? -40.644 -8.494 -36.479 1.00 14.19 ? 312 VAL A N 1 ATOM 2303 C CA . VAL A 1 328 ? -41.021 -7.089 -36.570 1.00 9.49 ? 312 VAL A CA 1 ATOM 2304 C C . VAL A 1 328 ? -40.510 -6.333 -35.351 1.00 15.05 ? 312 VAL A C 1 ATOM 2305 O O . VAL A 1 328 ? -40.928 -6.603 -34.225 1.00 27.08 ? 312 VAL A O 1 ATOM 2306 C CB . VAL A 1 328 ? -42.553 -6.925 -36.647 1.00 19.68 ? 312 VAL A CB 1 ATOM 2307 C CG1 . VAL A 1 328 ? -42.944 -5.452 -36.577 1.00 12.19 ? 312 VAL A CG1 1 ATOM 2308 C CG2 . VAL A 1 328 ? -43.100 -7.564 -37.917 1.00 15.36 ? 312 VAL A CG2 1 ATOM 2309 N N . ALA A 1 329 ? -39.605 -5.387 -35.579 1.00 16.68 ? 313 ALA A N 1 ATOM 2310 C CA . ALA A 1 329 ? -39.033 -4.598 -34.495 1.00 15.63 ? 313 ALA A CA 1 ATOM 2311 C C . ALA A 1 329 ? -39.843 -3.327 -34.270 1.00 16.36 ? 313 ALA A C 1 ATOM 2312 O O . ALA A 1 329 ? -40.477 -2.810 -35.189 1.00 16.86 ? 313 ALA A O 1 ATOM 2313 C CB . ALA A 1 329 ? -37.587 -4.258 -34.802 1.00 17.20 ? 313 ALA A CB 1 ATOM 2314 N N . GLU A 1 330 ? -39.813 -2.826 -33.039 1.00 20.65 ? 314 GLU A N 1 ATOM 2315 C CA . GLU A 1 330 ? -40.600 -1.660 -32.662 1.00 14.47 ? 314 GLU A CA 1 ATOM 2316 C C . GLU A 1 330 ? -39.701 -0.539 -32.150 1.00 13.14 ? 314 GLU A C 1 ATOM 2317 O O . GLU A 1 330 ? -38.928 -0.732 -31.212 1.00 17.93 ? 314 GLU A O 1 ATOM 2318 C CB . GLU A 1 330 ? -41.613 -2.047 -31.583 1.00 16.51 ? 314 GLU A CB 1 ATOM 2319 C CG . GLU A 1 330 ? -42.518 -0.912 -31.141 1.00 19.92 ? 314 GLU A CG 1 ATOM 2320 C CD . GLU A 1 330 ? -43.498 -1.337 -30.063 1.00 23.70 ? 314 GLU A CD 1 ATOM 2321 O OE1 . GLU A 1 330 ? -43.150 -2.229 -29.260 1.00 24.46 ? 314 GLU A OE1 1 ATOM 2322 O OE2 . GLU A 1 330 ? -44.617 -0.782 -30.021 1.00 26.31 ? 314 GLU A OE2 1 ATOM 2323 N N . THR A 1 331 ? -39.804 0.633 -32.771 1.00 17.01 ? 315 THR A N 1 ATOM 2324 C CA . THR A 1 331 ? -39.063 1.805 -32.315 1.00 15.93 ? 315 THR A CA 1 ATOM 2325 C C . THR A 1 331 ? -39.828 2.471 -31.179 1.00 15.02 ? 315 THR A C 1 ATOM 2326 O O . THR A 1 331 ? -40.945 2.066 -30.859 1.00 25.78 ? 315 THR A O 1 ATOM 2327 C CB . THR A 1 331 ? -38.850 2.827 -33.448 1.00 12.84 ? 315 THR A CB 1 ATOM 2328 O OG1 . THR A 1 331 ? -40.096 3.447 -33.783 1.00 15.70 ? 315 THR A OG1 1 ATOM 2329 C CG2 . THR A 1 331 ? -38.273 2.149 -34.685 1.00 15.30 ? 315 THR A CG2 1 ATOM 2330 N N . GLN A 1 332 ? -39.228 3.487 -30.568 1.00 13.75 ? 316 GLN A N 1 ATOM 2331 C CA . GLN A 1 332 ? -39.850 4.162 -29.434 1.00 10.89 ? 316 GLN A CA 1 ATOM 2332 C C . GLN A 1 332 ? -40.485 5.496 -29.816 1.00 10.44 ? 316 GLN A C 1 ATOM 2333 O O . GLN A 1 332 ? -40.780 6.317 -28.947 1.00 9.64 ? 316 GLN A O 1 ATOM 2334 C CB . GLN A 1 332 ? -38.824 4.373 -28.321 1.00 19.23 ? 316 GLN A CB 1 ATOM 2335 C CG . GLN A 1 332 ? -38.391 3.083 -27.641 1.00 15.66 ? 316 GLN A CG 1 ATOM 2336 C CD . GLN A 1 332 ? -39.568 2.273 -27.135 1.00 12.51 ? 316 GLN A CD 1 ATOM 2337 O OE1 . GLN A 1 332 ? -40.369 2.755 -26.333 1.00 16.10 ? 316 GLN A OE1 1 ATOM 2338 N NE2 . GLN A 1 332 ? -39.688 1.038 -27.612 1.00 12.21 ? 316 GLN A NE2 1 ATOM 2339 N N . HIS A 1 333 ? -40.699 5.709 -31.111 1.00 9.38 ? 317 HIS A N 1 ATOM 2340 C CA . HIS A 1 333 ? -41.361 6.925 -31.572 1.00 7.85 ? 317 HIS A CA 1 ATOM 2341 C C . HIS A 1 333 ? -42.408 6.651 -32.655 1.00 10.46 ? 317 HIS A C 1 ATOM 2342 O O . HIS A 1 333 ? -42.550 7.422 -33.603 1.00 16.70 ? 317 HIS A O 1 ATOM 2343 C CB . HIS A 1 333 ? -40.333 7.955 -32.054 1.00 7.00 ? 317 HIS A CB 1 ATOM 2344 C CG . HIS A 1 333 ? -39.440 7.462 -33.149 1.00 8.91 ? 317 HIS A CG 1 ATOM 2345 N ND1 . HIS A 1 333 ? -39.772 7.561 -34.482 1.00 9.07 ? 317 HIS A ND1 1 ATOM 2346 C CD2 . HIS A 1 333 ? -38.220 6.876 -33.108 1.00 10.17 ? 317 HIS A CD2 1 ATOM 2347 C CE1 . HIS A 1 333 ? -38.798 7.054 -35.216 1.00 7.88 ? 317 HIS A CE1 1 ATOM 2348 N NE2 . HIS A 1 333 ? -37.844 6.630 -34.406 1.00 7.06 ? 317 HIS A NE2 1 ATOM 2349 N N . GLY A 1 334 ? -43.134 5.545 -32.507 1.00 9.85 ? 318 GLY A N 1 ATOM 2350 C CA . GLY A 1 334 ? -44.335 5.307 -33.291 1.00 9.91 ? 318 GLY A CA 1 ATOM 2351 C C . GLY A 1 334 ? -44.180 4.487 -34.560 1.00 11.13 ? 318 GLY A C 1 ATOM 2352 O O . GLY A 1 334 ? -45.140 4.338 -35.314 1.00 9.19 ? 318 GLY A O 1 ATOM 2353 N N . THR A 1 335 ? -42.989 3.946 -34.798 1.00 13.42 ? 319 THR A N 1 ATOM 2354 C CA . THR A 1 335 ? -42.737 3.179 -36.016 1.00 14.15 ? 319 THR A CA 1 ATOM 2355 C C . THR A 1 335 ? -42.395 1.718 -35.729 1.00 15.36 ? 319 THR A C 1 ATOM 2356 O O . THR A 1 335 ? -42.213 1.322 -34.577 1.00 15.25 ? 319 THR A O 1 ATOM 2357 C CB . THR A 1 335 ? -41.580 3.790 -36.834 1.00 9.11 ? 319 THR A CB 1 ATOM 2358 O OG1 . THR A 1 335 ? -40.347 3.625 -36.122 1.00 10.75 ? 319 THR A OG1 1 ATOM 2359 C CG2 . THR A 1 335 ? -41.823 5.270 -37.094 1.00 5.62 ? 319 THR A CG2 1 ATOM 2360 N N . VAL A 1 336 ? -42.320 0.923 -36.793 1.00 13.62 ? 320 VAL A N 1 ATOM 2361 C CA . VAL A 1 336 ? -41.875 -0.463 -36.708 1.00 11.47 ? 320 VAL A CA 1 ATOM 2362 C C . VAL A 1 336 ? -41.007 -0.781 -37.919 1.00 12.58 ? 320 VAL A C 1 ATOM 2363 O O . VAL A 1 336 ? -41.252 -0.273 -39.014 1.00 15.13 ? 320 VAL A O 1 ATOM 2364 C CB . VAL A 1 336 ? -43.061 -1.448 -36.671 1.00 13.18 ? 320 VAL A CB 1 ATOM 2365 C CG1 . VAL A 1 336 ? -44.042 -1.061 -35.579 1.00 8.42 ? 320 VAL A CG1 1 ATOM 2366 C CG2 . VAL A 1 336 ? -43.763 -1.503 -38.025 1.00 14.40 ? 320 VAL A CG2 1 ATOM 2367 N N . LEU A 1 337 ? -39.992 -1.617 -37.722 1.00 14.84 ? 321 LEU A N 1 ATOM 2368 C CA A LEU A 1 337 ? -39.102 -1.991 -38.815 0.63 13.71 ? 321 LEU A CA 1 ATOM 2369 C CA B LEU A 1 337 ? -39.078 -1.997 -38.792 0.37 13.75 ? 321 LEU A CA 1 ATOM 2370 C C . LEU A 1 337 ? -39.391 -3.415 -39.264 1.00 10.62 ? 321 LEU A C 1 ATOM 2371 O O . LEU A 1 337 ? -39.389 -4.350 -38.463 1.00 15.93 ? 321 LEU A O 1 ATOM 2372 C CB A LEU A 1 337 ? -37.635 -1.848 -38.400 0.63 14.16 ? 321 LEU A CB 1 ATOM 2373 C CB B LEU A 1 337 ? -37.637 -1.926 -38.286 0.37 14.18 ? 321 LEU A CB 1 ATOM 2374 C CG A LEU A 1 337 ? -36.646 -1.637 -39.553 0.63 15.35 ? 321 LEU A CG 1 ATOM 2375 C CG B LEU A 1 337 ? -37.319 -0.734 -37.376 0.37 13.76 ? 321 LEU A CG 1 ATOM 2376 C CD1 A LEU A 1 337 ? -35.288 -1.203 -39.026 0.63 19.04 ? 321 LEU A CD1 1 ATOM 2377 C CD1 B LEU A 1 337 ? -36.083 -1.010 -36.534 0.37 14.76 ? 321 LEU A CD1 1 ATOM 2378 C CD2 A LEU A 1 337 ? -36.500 -2.887 -40.410 0.63 11.03 ? 321 LEU A CD2 1 ATOM 2379 C CD2 B LEU A 1 337 ? -37.138 0.534 -38.194 0.37 14.18 ? 321 LEU A CD2 1 ATOM 2380 N N . VAL A 1 338 ? -39.653 -3.569 -40.558 1.00 9.63 ? 322 VAL A N 1 ATOM 2381 C CA . VAL A 1 338 ? -39.984 -4.868 -41.132 1.00 9.79 ? 322 VAL A CA 1 ATOM 2382 C C . VAL A 1 338 ? -39.002 -5.246 -42.236 1.00 9.15 ? 322 VAL A C 1 ATOM 2383 O O . VAL A 1 338 ? -38.983 -4.627 -43.299 1.00 9.87 ? 322 VAL A O 1 ATOM 2384 C CB . VAL A 1 338 ? -41.405 -4.862 -41.726 1.00 13.34 ? 322 VAL A CB 1 ATOM 2385 C CG1 . VAL A 1 338 ? -41.751 -6.232 -42.286 1.00 12.08 ? 322 VAL A CG1 1 ATOM 2386 C CG2 . VAL A 1 338 ? -42.422 -4.435 -40.677 1.00 9.56 ? 322 VAL A CG2 1 ATOM 2387 N N . GLN A 1 339 ? -38.189 -6.266 -41.979 1.00 9.25 ? 323 GLN A N 1 ATOM 2388 C CA . GLN A 1 339 ? -37.253 -6.769 -42.977 1.00 9.44 ? 323 GLN A CA 1 ATOM 2389 C C . GLN A 1 339 ? -37.824 -8.024 -43.630 1.00 15.96 ? 323 GLN A C 1 ATOM 2390 O O . GLN A 1 339 ? -38.206 -8.972 -42.942 1.00 12.82 ? 323 GLN A O 1 ATOM 2391 C CB . GLN A 1 339 ? -35.901 -7.086 -42.336 1.00 10.57 ? 323 GLN A CB 1 ATOM 2392 C CG . GLN A 1 339 ? -34.795 -7.354 -43.343 1.00 10.78 ? 323 GLN A CG 1 ATOM 2393 C CD . GLN A 1 339 ? -33.552 -7.936 -42.701 1.00 12.64 ? 323 GLN A CD 1 ATOM 2394 O OE1 . GLN A 1 339 ? -33.552 -9.081 -42.251 1.00 22.87 ? 323 GLN A OE1 1 ATOM 2395 N NE2 . GLN A 1 339 ? -32.486 -7.146 -42.653 1.00 18.19 ? 323 GLN A NE2 1 ATOM 2396 N N . VAL A 1 340 ? -37.874 -8.029 -44.959 1.00 20.76 ? 324 VAL A N 1 ATOM 2397 C CA . VAL A 1 340 ? -38.445 -9.147 -45.702 1.00 14.81 ? 324 VAL A CA 1 ATOM 2398 C C . VAL A 1 340 ? -37.460 -9.689 -46.730 1.00 13.01 ? 324 VAL A C 1 ATOM 2399 O O . VAL A 1 340 ? -36.442 -9.063 -47.019 1.00 11.09 ? 324 VAL A O 1 ATOM 2400 C CB . VAL A 1 340 ? -39.740 -8.733 -46.435 1.00 16.21 ? 324 VAL A CB 1 ATOM 2401 C CG1 . VAL A 1 340 ? -40.749 -8.177 -45.450 1.00 8.79 ? 324 VAL A CG1 1 ATOM 2402 C CG2 . VAL A 1 340 ? -39.440 -7.711 -47.524 1.00 16.14 ? 324 VAL A CG2 1 ATOM 2403 N N . LYS A 1 341 ? -37.772 -10.862 -47.272 1.00 12.66 ? 325 LYS A N 1 ATOM 2404 C CA . LYS A 1 341 ? -36.973 -11.468 -48.330 1.00 11.97 ? 325 LYS A CA 1 ATOM 2405 C C . LYS A 1 341 ? -37.895 -11.944 -49.447 1.00 11.18 ? 325 LYS A C 1 ATOM 2406 O O . LYS A 1 341 ? -38.906 -12.595 -49.192 1.00 13.84 ? 325 LYS A O 1 ATOM 2407 C CB . LYS A 1 341 ? -36.157 -12.640 -47.782 1.00 14.61 ? 325 LYS A CB 1 ATOM 2408 C CG . LYS A 1 341 ? -35.368 -13.398 -48.845 1.00 23.54 ? 325 LYS A CG 1 ATOM 2409 C CD . LYS A 1 341 ? -33.865 -13.329 -48.610 1.00 24.54 ? 325 LYS A CD 1 ATOM 2410 C CE . LYS A 1 341 ? -33.230 -14.710 -48.640 1.00 34.21 ? 325 LYS A CE 1 ATOM 2411 N NZ . LYS A 1 341 ? -33.337 -15.402 -47.326 1.00 34.20 ? 325 LYS A NZ 1 ATOM 2412 N N . TYR A 1 342 ? -37.537 -11.620 -50.684 1.00 12.54 ? 326 TYR A N 1 ATOM 2413 C CA . TYR A 1 342 ? -38.400 -11.883 -51.831 1.00 8.19 ? 326 TYR A CA 1 ATOM 2414 C C . TYR A 1 342 ? -38.186 -13.282 -52.403 1.00 16.15 ? 326 TYR A C 1 ATOM 2415 O O . TYR A 1 342 ? -37.055 -13.761 -52.490 1.00 18.01 ? 326 TYR A O 1 ATOM 2416 C CB . TYR A 1 342 ? -38.147 -10.826 -52.906 1.00 9.54 ? 326 TYR A CB 1 ATOM 2417 C CG . TYR A 1 342 ? -39.113 -10.861 -54.066 1.00 9.22 ? 326 TYR A CG 1 ATOM 2418 C CD1 . TYR A 1 342 ? -40.484 -10.892 -53.855 1.00 10.63 ? 326 TYR A CD1 1 ATOM 2419 C CD2 . TYR A 1 342 ? -38.653 -10.835 -55.375 1.00 8.01 ? 326 TYR A CD2 1 ATOM 2420 C CE1 . TYR A 1 342 ? -41.370 -10.917 -54.916 1.00 9.76 ? 326 TYR A CE1 1 ATOM 2421 C CE2 . TYR A 1 342 ? -39.530 -10.859 -56.442 1.00 12.67 ? 326 TYR A CE2 1 ATOM 2422 C CZ . TYR A 1 342 ? -40.888 -10.898 -56.207 1.00 12.13 ? 326 TYR A CZ 1 ATOM 2423 O OH . TYR A 1 342 ? -41.773 -10.917 -57.261 1.00 11.59 ? 326 TYR A OH 1 ATOM 2424 N N . GLU A 1 343 ? -39.281 -13.925 -52.797 1.00 16.77 ? 327 GLU A N 1 ATOM 2425 C CA . GLU A 1 343 ? -39.238 -15.285 -53.325 1.00 20.28 ? 327 GLU A CA 1 ATOM 2426 C C . GLU A 1 343 ? -39.643 -15.329 -54.797 1.00 19.31 ? 327 GLU A C 1 ATOM 2427 O O . GLU A 1 343 ? -39.801 -16.407 -55.371 1.00 25.42 ? 327 GLU A O 1 ATOM 2428 C CB . GLU A 1 343 ? -40.162 -16.199 -52.514 1.00 28.43 ? 327 GLU A CB 1 ATOM 2429 C CG . GLU A 1 343 ? -39.498 -16.906 -51.346 1.00 31.38 ? 327 GLU A CG 1 ATOM 2430 C CD . GLU A 1 343 ? -40.315 -18.082 -50.841 1.00 45.77 ? 327 GLU A CD 1 ATOM 2431 O OE1 . GLU A 1 343 ? -41.169 -18.590 -51.599 1.00 49.04 ? 327 GLU A OE1 1 ATOM 2432 O OE2 . GLU A 1 343 ? -40.107 -18.497 -49.682 1.00 64.16 ? 327 GLU A OE2 1 ATOM 2433 N N . GLY A 1 344 ? -39.810 -14.160 -55.407 1.00 15.45 ? 328 GLY A N 1 ATOM 2434 C CA . GLY A 1 344 ? -40.258 -14.085 -56.786 1.00 12.88 ? 328 GLY A CA 1 ATOM 2435 C C . GLY A 1 344 ? -39.115 -14.033 -57.781 1.00 15.40 ? 328 GLY A C 1 ATOM 2436 O O . GLY A 1 344 ? -37.948 -14.124 -57.404 1.00 16.82 ? 328 GLY A O 1 ATOM 2437 N N . THR A 1 345 ? -39.457 -13.878 -59.058 1.00 18.64 ? 329 THR A N 1 ATOM 2438 C CA . THR A 1 345 ? -38.477 -13.953 -60.138 1.00 15.60 ? 329 THR A CA 1 ATOM 2439 C C . THR A 1 345 ? -38.426 -12.686 -60.991 1.00 18.15 ? 329 THR A C 1 ATOM 2440 O O . THR A 1 345 ? -37.911 -12.710 -62.109 1.00 19.84 ? 329 THR A O 1 ATOM 2441 C CB . THR A 1 345 ? -38.794 -15.134 -61.078 1.00 20.89 ? 329 THR A CB 1 ATOM 2442 O OG1 . THR A 1 345 ? -40.170 -15.072 -61.473 1.00 20.76 ? 329 THR A OG1 1 ATOM 2443 C CG2 . THR A 1 345 ? -38.529 -16.461 -60.387 1.00 17.89 ? 329 THR A CG2 1 ATOM 2444 N N . ASP A 1 346 ? -38.948 -11.581 -60.469 1.00 21.49 ? 330 ASP A N 1 ATOM 2445 C CA . ASP A 1 346 ? -39.078 -10.360 -61.263 1.00 12.59 ? 330 ASP A CA 1 ATOM 2446 C C . ASP A 1 346 ? -38.333 -9.165 -60.672 1.00 15.41 ? 330 ASP A C 1 ATOM 2447 O O . ASP A 1 346 ? -38.718 -8.018 -60.896 1.00 22.21 ? 330 ASP A O 1 ATOM 2448 C CB . ASP A 1 346 ? -40.557 -10.008 -61.448 1.00 12.77 ? 330 ASP A CB 1 ATOM 2449 C CG . ASP A 1 346 ? -41.317 -9.971 -60.139 1.00 10.69 ? 330 ASP A CG 1 ATOM 2450 O OD1 . ASP A 1 346 ? -40.871 -10.625 -59.173 1.00 14.54 ? 330 ASP A OD1 1 ATOM 2451 O OD2 . ASP A 1 346 ? -42.363 -9.293 -60.077 1.00 9.82 ? 330 ASP A OD2 1 ATOM 2452 N N . ALA A 1 347 ? -37.266 -9.429 -59.926 1.00 16.67 ? 331 ALA A N 1 ATOM 2453 C CA . ALA A 1 347 ? -36.430 -8.353 -59.406 1.00 15.48 ? 331 ALA A CA 1 ATOM 2454 C C . ALA A 1 347 ? -35.584 -7.766 -60.534 1.00 15.47 ? 331 ALA A C 1 ATOM 2455 O O . ALA A 1 347 ? -35.167 -8.492 -61.436 1.00 14.70 ? 331 ALA A O 1 ATOM 2456 C CB . ALA A 1 347 ? -35.543 -8.866 -58.287 1.00 11.94 ? 331 ALA A CB 1 ATOM 2457 N N . PRO A 1 348 ? -35.324 -6.450 -60.485 1.00 14.79 ? 332 PRO A N 1 ATOM 2458 C CA . PRO A 1 348 ? -35.757 -5.554 -59.408 1.00 9.86 ? 332 PRO A CA 1 ATOM 2459 C C . PRO A 1 348 ? -37.226 -5.162 -59.534 1.00 11.82 ? 332 PRO A C 1 ATOM 2460 O O . PRO A 1 348 ? -37.718 -4.984 -60.648 1.00 9.85 ? 332 PRO A O 1 ATOM 2461 C CB . PRO A 1 348 ? -34.862 -4.332 -59.603 1.00 14.28 ? 332 PRO A CB 1 ATOM 2462 C CG . PRO A 1 348 ? -34.619 -4.292 -61.066 1.00 7.86 ? 332 PRO A CG 1 ATOM 2463 C CD . PRO A 1 348 ? -34.545 -5.731 -61.510 1.00 14.79 ? 332 PRO A CD 1 ATOM 2464 N N . CYS A 1 349 ? -37.913 -5.022 -58.403 1.00 16.34 ? 333 CYS A N 1 ATOM 2465 C CA . CYS A 1 349 ? -39.336 -4.697 -58.413 1.00 9.35 ? 333 CYS A CA 1 ATOM 2466 C C . CYS A 1 349 ? -39.751 -3.903 -57.176 1.00 11.04 ? 333 CYS A C 1 ATOM 2467 O O . CYS A 1 349 ? -39.052 -3.892 -56.163 1.00 7.70 ? 333 CYS A O 1 ATOM 2468 C CB . CYS A 1 349 ? -40.173 -5.975 -58.524 1.00 8.32 ? 333 CYS A CB 1 ATOM 2469 S SG . CYS A 1 349 ? -39.838 -7.205 -57.246 1.00 3.85 ? 333 CYS A SG 1 ATOM 2470 N N . LYS A 1 350 ? -40.895 -3.233 -57.280 1.00 12.84 ? 334 LYS A N 1 ATOM 2471 C CA . LYS A 1 350 ? -41.430 -2.418 -56.197 1.00 9.24 ? 334 LYS A CA 1 ATOM 2472 C C . LYS A 1 350 ? -42.267 -3.266 -55.243 1.00 11.61 ? 334 LYS A C 1 ATOM 2473 O O . LYS A 1 350 ? -43.255 -3.876 -55.647 1.00 11.73 ? 334 LYS A O 1 ATOM 2474 C CB . LYS A 1 350 ? -42.284 -1.294 -56.784 1.00 12.76 ? 334 LYS A CB 1 ATOM 2475 C CG . LYS A 1 350 ? -42.919 -0.360 -55.763 1.00 23.87 ? 334 LYS A CG 1 ATOM 2476 C CD . LYS A 1 350 ? -42.032 0.835 -55.450 1.00 19.63 ? 334 LYS A CD 1 ATOM 2477 C CE . LYS A 1 350 ? -42.873 2.064 -55.145 1.00 30.36 ? 334 LYS A CE 1 ATOM 2478 N NZ . LYS A 1 350 ? -42.052 3.232 -54.727 1.00 35.29 ? 334 LYS A NZ 1 ATOM 2479 N N . ILE A 1 351 ? -41.871 -3.296 -53.975 1.00 13.25 ? 335 ILE A N 1 ATOM 2480 C CA . ILE A 1 351 ? -42.579 -4.083 -52.970 1.00 11.90 ? 335 ILE A CA 1 ATOM 2481 C C . ILE A 1 351 ? -43.959 -3.500 -52.689 1.00 11.34 ? 335 ILE A C 1 ATOM 2482 O O . ILE A 1 351 ? -44.070 -2.375 -52.201 1.00 10.20 ? 335 ILE A O 1 ATOM 2483 C CB . ILE A 1 351 ? -41.795 -4.138 -51.645 1.00 9.03 ? 335 ILE A CB 1 ATOM 2484 C CG1 . ILE A 1 351 ? -40.451 -4.837 -51.855 1.00 9.55 ? 335 ILE A CG1 1 ATOM 2485 C CG2 . ILE A 1 351 ? -42.606 -4.863 -50.579 1.00 7.59 ? 335 ILE A CG2 1 ATOM 2486 C CD1 . ILE A 1 351 ? -39.582 -4.890 -50.619 1.00 6.42 ? 335 ILE A CD1 1 ATOM 2487 N N . PRO A 1 352 ? -45.021 -4.263 -52.997 1.00 9.72 ? 336 PRO A N 1 ATOM 2488 C CA . PRO A 1 352 ? -46.375 -3.807 -52.667 1.00 8.71 ? 336 PRO A CA 1 ATOM 2489 C C . PRO A 1 352 ? -46.583 -3.741 -51.158 1.00 9.17 ? 336 PRO A C 1 ATOM 2490 O O . PRO A 1 352 ? -46.437 -4.759 -50.483 1.00 14.61 ? 336 PRO A O 1 ATOM 2491 C CB . PRO A 1 352 ? -47.277 -4.890 -53.275 1.00 9.62 ? 336 PRO A CB 1 ATOM 2492 C CG . PRO A 1 352 ? -46.414 -5.661 -54.215 1.00 10.60 ? 336 PRO A CG 1 ATOM 2493 C CD . PRO A 1 352 ? -45.029 -5.571 -53.672 1.00 7.71 ? 336 PRO A CD 1 ATOM 2494 N N . PHE A 1 353 ? -46.913 -2.564 -50.639 1.00 14.29 ? 337 PHE A N 1 ATOM 2495 C CA . PHE A 1 353 ? -47.114 -2.396 -49.205 1.00 15.74 ? 337 PHE A CA 1 ATOM 2496 C C . PHE A 1 353 ? -48.479 -1.787 -48.913 1.00 16.15 ? 337 PHE A C 1 ATOM 2497 O O . PHE A 1 353 ? -48.997 -0.993 -49.698 1.00 26.70 ? 337 PHE A O 1 ATOM 2498 C CB . PHE A 1 353 ? -46.015 -1.512 -48.615 1.00 21.35 ? 337 PHE A CB 1 ATOM 2499 C CG . PHE A 1 353 ? -46.104 -1.350 -47.124 1.00 18.08 ? 337 PHE A CG 1 ATOM 2500 C CD1 . PHE A 1 353 ? -46.838 -0.316 -46.566 1.00 19.44 ? 337 PHE A CD1 1 ATOM 2501 C CD2 . PHE A 1 353 ? -45.448 -2.230 -46.279 1.00 11.56 ? 337 PHE A CD2 1 ATOM 2502 C CE1 . PHE A 1 353 ? -46.918 -0.165 -45.193 1.00 18.78 ? 337 PHE A CE1 1 ATOM 2503 C CE2 . PHE A 1 353 ? -45.524 -2.084 -44.907 1.00 13.09 ? 337 PHE A CE2 1 ATOM 2504 C CZ . PHE A 1 353 ? -46.260 -1.051 -44.364 1.00 17.40 ? 337 PHE A CZ 1 ATOM 2505 N N . SER A 1 354 ? -49.056 -2.166 -47.778 1.00 13.77 ? 338 SER A N 1 ATOM 2506 C CA . SER A 1 354 ? -50.370 -1.673 -47.387 1.00 12.16 ? 338 SER A CA 1 ATOM 2507 C C . SER A 1 354 ? -50.574 -1.779 -45.879 1.00 19.18 ? 338 SER A C 1 ATOM 2508 O O . SER A 1 354 ? -50.023 -2.665 -45.225 1.00 18.59 ? 338 SER A O 1 ATOM 2509 C CB . SER A 1 354 ? -51.463 -2.457 -48.113 1.00 22.35 ? 338 SER A CB 1 ATOM 2510 O OG . SER A 1 354 ? -52.748 -2.093 -47.639 1.00 23.53 ? 338 SER A OG 1 ATOM 2511 N N . SER A 1 355 ? -51.374 -0.867 -45.335 1.00 22.26 ? 339 SER A N 1 ATOM 2512 C CA . SER A 1 355 ? -51.688 -0.863 -43.912 1.00 14.48 ? 339 SER A CA 1 ATOM 2513 C C . SER A 1 355 ? -53.199 -0.806 -43.724 1.00 14.21 ? 339 SER A C 1 ATOM 2514 O O . SER A 1 355 ? -53.893 -0.085 -44.441 1.00 16.17 ? 339 SER A O 1 ATOM 2515 C CB . SER A 1 355 ? -51.025 0.332 -43.222 1.00 17.67 ? 339 SER A CB 1 ATOM 2516 O OG . SER A 1 355 ? -51.298 0.345 -41.830 1.00 14.19 ? 339 SER A OG 1 ATOM 2517 N N . GLN A 1 356 ? -53.706 -1.567 -42.761 1.00 18.94 ? 340 GLN A N 1 ATOM 2518 C CA . GLN A 1 356 ? -55.142 -1.627 -42.516 1.00 19.21 ? 340 GLN A CA 1 ATOM 2519 C C . GLN A 1 356 ? -55.445 -1.564 -41.026 1.00 15.58 ? 340 GLN A C 1 ATOM 2520 O O . GLN A 1 356 ? -54.916 -2.353 -40.246 1.00 20.45 ? 340 GLN A O 1 ATOM 2521 C CB . GLN A 1 356 ? -55.719 -2.913 -43.108 1.00 21.58 ? 340 GLN A CB 1 ATOM 2522 C CG . GLN A 1 356 ? -55.429 -3.094 -44.591 1.00 31.97 ? 340 GLN A CG 1 ATOM 2523 C CD . GLN A 1 356 ? -55.945 -4.413 -45.132 1.00 40.44 ? 340 GLN A CD 1 ATOM 2524 O OE1 . GLN A 1 356 ? -56.695 -5.123 -44.461 1.00 49.01 ? 340 GLN A OE1 1 ATOM 2525 N NE2 . GLN A 1 356 ? -55.544 -4.750 -46.353 1.00 41.90 ? 340 GLN A NE2 1 ATOM 2526 N N . ASP A 1 357 ? -56.298 -0.623 -40.632 1.00 21.20 ? 341 ASP A N 1 ATOM 2527 C CA . ASP A 1 357 ? -56.667 -0.478 -39.231 1.00 21.48 ? 341 ASP A CA 1 ATOM 2528 C C . ASP A 1 357 ? -57.460 -1.695 -38.767 1.00 26.89 ? 341 ASP A C 1 ATOM 2529 O O . ASP A 1 357 ? -57.791 -2.575 -39.565 1.00 32.13 ? 341 ASP A O 1 ATOM 2530 C CB . ASP A 1 357 ? -57.473 0.804 -39.006 1.00 28.04 ? 341 ASP A CB 1 ATOM 2531 C CG . ASP A 1 357 ? -58.762 0.832 -39.801 1.00 30.83 ? 341 ASP A CG 1 ATOM 2532 O OD1 . ASP A 1 357 ? -59.149 -0.217 -40.359 1.00 34.89 ? 341 ASP A OD1 1 ATOM 2533 O OD2 . ASP A 1 357 ? -59.394 1.906 -39.864 1.00 27.37 ? 341 ASP A OD2 1 ATOM 2534 N N . GLU A 1 358 ? -57.766 -1.734 -37.475 1.00 32.46 ? 342 GLU A N 1 ATOM 2535 C CA . GLU A 1 358 ? -58.456 -2.874 -36.876 1.00 31.57 ? 342 GLU A CA 1 ATOM 2536 C C . GLU A 1 358 ? -59.630 -3.399 -37.704 1.00 35.01 ? 342 GLU A C 1 ATOM 2537 O O . GLU A 1 358 ? -60.012 -4.560 -37.555 1.00 44.41 ? 342 GLU A O 1 ATOM 2538 C CB . GLU A 1 358 ? -58.929 -2.560 -35.445 1.00 33.74 ? 342 GLU A CB 1 ATOM 2539 C CG . GLU A 1 358 ? -59.093 -1.083 -35.088 1.00 34.77 ? 342 GLU A CG 1 ATOM 2540 C CD . GLU A 1 358 ? -60.017 -0.341 -36.031 1.00 38.42 ? 342 GLU A CD 1 ATOM 2541 O OE1 . GLU A 1 358 ? -60.697 -1.002 -36.840 1.00 35.66 ? 342 GLU A OE1 1 ATOM 2542 O OE2 . GLU A 1 358 ? -60.071 0.906 -35.954 1.00 44.76 ? 342 GLU A OE2 1 ATOM 2543 N N . LYS A 1 359 ? -60.201 -2.561 -38.567 1.00 43.60 ? 343 LYS A N 1 ATOM 2544 C CA . LYS A 1 359 ? -61.339 -2.984 -39.384 1.00 42.98 ? 343 LYS A CA 1 ATOM 2545 C C . LYS A 1 359 ? -61.134 -2.768 -40.885 1.00 41.28 ? 343 LYS A C 1 ATOM 2546 O O . LYS A 1 359 ? -61.937 -2.113 -41.547 1.00 48.89 ? 343 LYS A O 1 ATOM 2547 C CB . LYS A 1 359 ? -62.616 -2.285 -38.913 1.00 43.22 ? 343 LYS A CB 1 ATOM 2548 C CG . LYS A 1 359 ? -63.114 -2.764 -37.552 1.00 49.22 ? 343 LYS A CG 1 ATOM 2549 C CD . LYS A 1 359 ? -63.429 -4.255 -37.560 1.00 40.09 ? 343 LYS A CD 1 ATOM 2550 C CE . LYS A 1 359 ? -63.814 -4.757 -36.180 1.00 31.78 ? 343 LYS A CE 1 ATOM 2551 N NZ . LYS A 1 359 ? -63.955 -6.238 -36.164 1.00 42.78 ? 343 LYS A NZ 1 ATOM 2552 N N . GLY A 1 360 ? -60.047 -3.329 -41.404 1.00 39.52 ? 344 GLY A N 1 ATOM 2553 C CA . GLY A 1 360 ? -59.834 -3.441 -42.836 1.00 36.20 ? 344 GLY A CA 1 ATOM 2554 C C . GLY A 1 360 ? -59.996 -2.169 -43.649 1.00 32.84 ? 344 GLY A C 1 ATOM 2555 O O . GLY A 1 360 ? -60.535 -2.207 -44.753 1.00 39.32 ? 344 GLY A O 1 ATOM 2556 N N . VAL A 1 361 ? -59.533 -1.044 -43.115 1.00 31.85 ? 345 VAL A N 1 ATOM 2557 C CA . VAL A 1 361 ? -59.503 0.196 -43.881 1.00 33.67 ? 345 VAL A CA 1 ATOM 2558 C C . VAL A 1 361 ? -58.091 0.461 -44.385 1.00 28.03 ? 345 VAL A C 1 ATOM 2559 O O . VAL A 1 361 ? -57.188 0.733 -43.596 1.00 27.48 ? 345 VAL A O 1 ATOM 2560 C CB . VAL A 1 361 ? -59.944 1.404 -43.038 1.00 33.88 ? 345 VAL A CB 1 ATOM 2561 C CG1 . VAL A 1 361 ? -60.047 2.645 -43.912 1.00 30.01 ? 345 VAL A CG1 1 ATOM 2562 C CG2 . VAL A 1 361 ? -61.270 1.127 -42.355 1.00 44.38 ? 345 VAL A CG2 1 ATOM 2563 N N . THR A 1 362 ? -57.901 0.384 -45.698 1.00 32.01 ? 346 THR A N 1 ATOM 2564 C CA . THR A 1 362 ? -56.596 0.662 -46.284 1.00 25.80 ? 346 THR A CA 1 ATOM 2565 C C . THR A 1 362 ? -56.291 2.144 -46.094 1.00 21.20 ? 346 THR A C 1 ATOM 2566 O O . THR A 1 362 ? -57.122 2.999 -46.400 1.00 20.02 ? 346 THR A O 1 ATOM 2567 C CB . THR A 1 362 ? -56.546 0.296 -47.782 1.00 28.74 ? 346 THR A CB 1 ATOM 2568 O OG1 . THR A 1 362 ? -56.906 -1.081 -47.958 1.00 38.81 ? 346 THR A OG1 1 ATOM 2569 C CG2 . THR A 1 362 ? -55.146 0.518 -48.341 1.00 17.98 ? 346 THR A CG2 1 ATOM 2570 N N . GLN A 1 363 ? -55.099 2.443 -45.587 1.00 18.33 ? 347 GLN A N 1 ATOM 2571 C CA . GLN A 1 363 ? -54.771 3.797 -45.152 1.00 15.67 ? 347 GLN A CA 1 ATOM 2572 C C . GLN A 1 363 ? -54.147 4.655 -46.251 1.00 13.38 ? 347 GLN A C 1 ATOM 2573 O O . GLN A 1 363 ? -54.089 5.878 -46.127 1.00 11.86 ? 347 GLN A O 1 ATOM 2574 C CB . GLN A 1 363 ? -53.834 3.741 -43.943 1.00 12.86 ? 347 GLN A CB 1 ATOM 2575 C CG . GLN A 1 363 ? -54.393 2.950 -42.770 1.00 17.98 ? 347 GLN A CG 1 ATOM 2576 C CD . GLN A 1 363 ? -55.762 3.443 -42.334 1.00 19.35 ? 347 GLN A CD 1 ATOM 2577 O OE1 . GLN A 1 363 ? -56.758 3.228 -43.024 1.00 26.87 ? 347 GLN A OE1 1 ATOM 2578 N NE2 . GLN A 1 363 ? -55.817 4.112 -41.187 1.00 14.51 ? 347 GLN A NE2 1 ATOM 2579 N N . ASN A 1 364 ? -53.684 4.017 -47.321 1.00 17.77 ? 348 ASN A N 1 ATOM 2580 C CA . ASN A 1 364 ? -53.074 4.739 -48.432 1.00 15.52 ? 348 ASN A CA 1 ATOM 2581 C C . ASN A 1 364 ? -51.955 5.658 -47.951 1.00 11.63 ? 348 ASN A C 1 ATOM 2582 O O . ASN A 1 364 ? -51.848 6.804 -48.386 1.00 14.31 ? 348 ASN A O 1 ATOM 2583 C CB . ASN A 1 364 ? -54.126 5.556 -49.184 1.00 10.36 ? 348 ASN A CB 1 ATOM 2584 C CG . ASN A 1 364 ? -55.196 4.690 -49.821 1.00 8.24 ? 348 ASN A CG 1 ATOM 2585 O OD1 . ASN A 1 364 ? -56.379 4.815 -49.508 1.00 12.08 ? 348 ASN A OD1 1 ATOM 2586 N ND2 . ASN A 1 364 ? -54.784 3.812 -50.727 1.00 10.12 ? 348 ASN A ND2 1 ATOM 2587 N N . GLY A 1 365 ? -51.127 5.146 -47.047 1.00 10.52 ? 349 GLY A N 1 ATOM 2588 C CA . GLY A 1 365 ? -50.017 5.907 -46.504 1.00 8.81 ? 349 GLY A CA 1 ATOM 2589 C C . GLY A 1 365 ? -49.290 5.124 -45.429 1.00 10.46 ? 349 GLY A C 1 ATOM 2590 O O . GLY A 1 365 ? -49.275 3.895 -45.446 1.00 12.91 ? 349 GLY A O 1 ATOM 2591 N N . ARG A 1 366 ? -48.678 5.845 -44.495 1.00 13.74 ? 350 ARG A N 1 ATOM 2592 C CA . ARG A 1 366 ? -47.994 5.238 -43.354 1.00 10.31 ? 350 ARG A CA 1 ATOM 2593 C C . ARG A 1 366 ? -46.734 4.468 -43.754 1.00 7.86 ? 350 ARG A C 1 ATOM 2594 O O . ARG A 1 366 ? -46.151 3.753 -42.939 1.00 10.83 ? 350 ARG A O 1 ATOM 2595 C CB . ARG A 1 366 ? -48.945 4.325 -42.574 1.00 8.81 ? 350 ARG A CB 1 ATOM 2596 C CG . ARG A 1 366 ? -50.095 5.060 -41.919 1.00 5.57 ? 350 ARG A CG 1 ATOM 2597 C CD . ARG A 1 366 ? -50.967 4.110 -41.126 1.00 6.30 ? 350 ARG A CD 1 ATOM 2598 N NE . ARG A 1 366 ? -52.114 4.790 -40.534 1.00 7.07 ? 350 ARG A NE 1 ATOM 2599 C CZ . ARG A 1 366 ? -52.062 5.552 -39.446 1.00 3.22 ? 350 ARG A CZ 1 ATOM 2600 N NH1 . ARG A 1 366 ? -50.911 5.757 -38.817 1.00 6.24 ? 350 ARG A NH1 1 ATOM 2601 N NH2 . ARG A 1 366 ? -53.165 6.125 -38.989 1.00 2.92 ? 350 ARG A NH2 1 ATOM 2602 N N . LEU A 1 367 ? -46.311 4.622 -45.005 1.00 7.45 ? 351 LEU A N 1 ATOM 2603 C CA . LEU A 1 367 ? -45.065 4.020 -45.466 1.00 9.13 ? 351 LEU A CA 1 ATOM 2604 C C . LEU A 1 367 ? -43.942 5.045 -45.374 1.00 7.61 ? 351 LEU A C 1 ATOM 2605 O O . LEU A 1 367 ? -43.960 6.063 -46.065 1.00 7.61 ? 351 LEU A O 1 ATOM 2606 C CB . LEU A 1 367 ? -45.209 3.512 -46.902 1.00 11.66 ? 351 LEU A CB 1 ATOM 2607 C CG . LEU A 1 367 ? -43.965 2.882 -47.535 1.00 9.29 ? 351 LEU A CG 1 ATOM 2608 C CD1 . LEU A 1 367 ? -43.406 1.775 -46.657 1.00 13.46 ? 351 LEU A CD1 1 ATOM 2609 C CD2 . LEU A 1 367 ? -44.292 2.348 -48.922 1.00 6.83 ? 351 LEU A CD2 1 ATOM 2610 N N . ILE A 1 368 ? -42.969 4.769 -44.513 1.00 6.76 ? 352 ILE A N 1 ATOM 2611 C CA . ILE A 1 368 ? -41.897 5.719 -44.239 1.00 10.51 ? 352 ILE A CA 1 ATOM 2612 C C . ILE A 1 368 ? -40.742 5.575 -45.225 1.00 16.31 ? 352 ILE A C 1 ATOM 2613 O O . ILE A 1 368 ? -40.187 6.570 -45.688 1.00 23.82 ? 352 ILE A O 1 ATOM 2614 C CB . ILE A 1 368 ? -41.378 5.564 -42.798 1.00 11.61 ? 352 ILE A CB 1 ATOM 2615 C CG1 . ILE A 1 368 ? -42.413 6.109 -41.811 1.00 5.46 ? 352 ILE A CG1 1 ATOM 2616 C CG2 . ILE A 1 368 ? -40.060 6.297 -42.624 1.00 15.36 ? 352 ILE A CG2 1 ATOM 2617 C CD1 . ILE A 1 368 ? -42.089 5.839 -40.356 1.00 5.09 ? 352 ILE A CD1 1 ATOM 2618 N N . THR A 1 369 ? -40.381 4.337 -45.545 1.00 22.43 ? 353 THR A N 1 ATOM 2619 C CA . THR A 1 369 ? -39.309 4.085 -46.500 1.00 15.98 ? 353 THR A CA 1 ATOM 2620 C C . THR A 1 369 ? -39.631 4.716 -47.848 1.00 19.49 ? 353 THR A C 1 ATOM 2621 O O . THR A 1 369 ? -40.715 4.519 -48.398 1.00 21.75 ? 353 THR A O 1 ATOM 2622 C CB . THR A 1 369 ? -39.072 2.577 -46.698 1.00 14.90 ? 353 THR A CB 1 ATOM 2623 O OG1 . THR A 1 369 ? -38.541 2.011 -45.494 1.00 13.36 ? 353 THR A OG1 1 ATOM 2624 C CG2 . THR A 1 369 ? -38.094 2.330 -47.837 1.00 16.65 ? 353 THR A CG2 1 ATOM 2625 N N . ALA A 1 370 ? -38.679 5.474 -48.378 1.00 21.36 ? 354 ALA A N 1 ATOM 2626 C CA . ALA A 1 370 ? -38.861 6.146 -49.657 1.00 15.52 ? 354 ALA A CA 1 ATOM 2627 C C . ALA A 1 370 ? -38.777 5.150 -50.806 1.00 17.75 ? 354 ALA A C 1 ATOM 2628 O O . ALA A 1 370 ? -39.617 5.155 -51.705 1.00 28.42 ? 354 ALA A O 1 ATOM 2629 C CB . ALA A 1 370 ? -37.817 7.236 -49.830 1.00 19.31 ? 354 ALA A CB 1 ATOM 2630 N N . ASN A 1 371 ? -37.763 4.291 -50.764 1.00 18.81 ? 355 ASN A N 1 ATOM 2631 C CA . ASN A 1 371 ? -37.513 3.348 -51.846 1.00 19.08 ? 355 ASN A CA 1 ATOM 2632 C C . ASN A 1 371 ? -37.682 1.895 -51.411 1.00 15.35 ? 355 ASN A C 1 ATOM 2633 O O . ASN A 1 371 ? -36.698 1.204 -51.149 1.00 17.32 ? 355 ASN A O 1 ATOM 2634 C CB . ASN A 1 371 ? -36.104 3.555 -52.400 1.00 24.97 ? 355 ASN A CB 1 ATOM 2635 C CG . ASN A 1 371 ? -35.891 4.956 -52.943 1.00 23.56 ? 355 ASN A CG 1 ATOM 2636 O OD1 . ASN A 1 371 ? -35.050 5.703 -52.444 1.00 16.04 ? 355 ASN A OD1 1 ATOM 2637 N ND2 . ASN A 1 371 ? -36.655 5.319 -53.968 1.00 24.70 ? 355 ASN A ND2 1 ATOM 2638 N N . PRO A 1 372 ? -38.936 1.427 -51.335 1.00 15.48 ? 356 PRO A N 1 ATOM 2639 C CA . PRO A 1 372 ? -39.251 0.033 -51.009 1.00 14.34 ? 356 PRO A CA 1 ATOM 2640 C C . PRO A 1 372 ? -39.035 -0.877 -52.214 1.00 11.12 ? 356 PRO A C 1 ATOM 2641 O O . PRO A 1 372 ? -40.001 -1.396 -52.773 1.00 9.22 ? 356 PRO A O 1 ATOM 2642 C CB . PRO A 1 372 ? -40.735 0.097 -50.647 1.00 9.91 ? 356 PRO A CB 1 ATOM 2643 C CG . PRO A 1 372 ? -41.261 1.205 -51.486 1.00 10.20 ? 356 PRO A CG 1 ATOM 2644 C CD . PRO A 1 372 ? -40.155 2.228 -51.545 1.00 14.64 ? 356 PRO A CD 1 ATOM 2645 N N . ILE A 1 373 ? -37.778 -1.062 -52.606 1.00 13.72 ? 357 ILE A N 1 ATOM 2646 C CA . ILE A 1 373 ? -37.456 -1.800 -53.821 1.00 10.88 ? 357 ILE A CA 1 ATOM 2647 C C . ILE A 1 373 ? -36.630 -3.052 -53.539 1.00 12.09 ? 357 ILE A C 1 ATOM 2648 O O . ILE A 1 373 ? -35.657 -3.012 -52.787 1.00 11.21 ? 357 ILE A O 1 ATOM 2649 C CB . ILE A 1 373 ? -36.657 -0.920 -54.803 1.00 12.19 ? 357 ILE A CB 1 ATOM 2650 C CG1 . ILE A 1 373 ? -37.403 0.387 -55.088 1.00 9.40 ? 357 ILE A CG1 1 ATOM 2651 C CG2 . ILE A 1 373 ? -36.377 -1.677 -56.095 1.00 10.61 ? 357 ILE A CG2 1 ATOM 2652 C CD1 . ILE A 1 373 ? -38.711 0.203 -55.809 1.00 12.81 ? 357 ILE A CD1 1 ATOM 2653 N N . VAL A 1 374 ? -37.027 -4.162 -54.154 1.00 12.45 ? 358 VAL A N 1 ATOM 2654 C CA . VAL A 1 374 ? -36.213 -5.369 -54.156 1.00 12.09 ? 358 VAL A CA 1 ATOM 2655 C C . VAL A 1 374 ? -35.231 -5.292 -55.314 1.00 12.34 ? 358 VAL A C 1 ATOM 2656 O O . VAL A 1 374 ? -35.477 -5.853 -56.378 1.00 14.79 ? 358 VAL A O 1 ATOM 2657 C CB . VAL A 1 374 ? -37.068 -6.638 -54.335 1.00 8.07 ? 358 VAL A CB 1 ATOM 2658 C CG1 . VAL A 1 374 ? -36.184 -7.876 -54.358 1.00 8.39 ? 358 VAL A CG1 1 ATOM 2659 C CG2 . VAL A 1 374 ? -38.102 -6.749 -53.233 1.00 8.42 ? 358 VAL A CG2 1 ATOM 2660 N N . THR A 1 375 ? -34.122 -4.592 -55.109 1.00 15.63 ? 359 THR A N 1 ATOM 2661 C CA . THR A 1 375 ? -33.126 -4.428 -56.160 1.00 13.04 ? 359 THR A CA 1 ATOM 2662 C C . THR A 1 375 ? -32.374 -5.733 -56.385 1.00 14.77 ? 359 THR A C 1 ATOM 2663 O O . THR A 1 375 ? -31.871 -5.993 -57.478 1.00 18.66 ? 359 THR A O 1 ATOM 2664 C CB . THR A 1 375 ? -32.123 -3.312 -55.817 1.00 16.56 ? 359 THR A CB 1 ATOM 2665 O OG1 . THR A 1 375 ? -31.458 -3.620 -54.585 1.00 17.73 ? 359 THR A OG1 1 ATOM 2666 C CG2 . THR A 1 375 ? -32.837 -1.971 -55.686 1.00 14.16 ? 359 THR A CG2 1 ATOM 2667 N N . ASP A 1 376 ? -32.308 -6.555 -55.344 1.00 18.39 ? 360 ASP A N 1 ATOM 2668 C CA . ASP A 1 376 ? -31.642 -7.847 -55.422 1.00 16.24 ? 360 ASP A CA 1 ATOM 2669 C C . ASP A 1 376 ? -32.469 -8.891 -54.682 1.00 17.66 ? 360 ASP A C 1 ATOM 2670 O O . ASP A 1 376 ? -32.830 -8.701 -53.520 1.00 22.27 ? 360 ASP A O 1 ATOM 2671 C CB . ASP A 1 376 ? -30.239 -7.758 -54.821 1.00 19.12 ? 360 ASP A CB 1 ATOM 2672 C CG . ASP A 1 376 ? -29.441 -9.035 -55.001 1.00 25.82 ? 360 ASP A CG 1 ATOM 2673 O OD1 . ASP A 1 376 ? -30.048 -10.087 -55.289 1.00 29.95 ? 360 ASP A OD1 1 ATOM 2674 O OD2 . ASP A 1 376 ? -28.203 -8.984 -54.853 1.00 22.46 ? 360 ASP A OD2 1 ATOM 2675 N N . LYS A 1 377 ? -32.768 -9.991 -55.364 1.00 22.89 ? 361 LYS A N 1 ATOM 2676 C CA . LYS A 1 377 ? -33.610 -11.043 -54.806 1.00 17.61 ? 361 LYS A CA 1 ATOM 2677 C C . LYS A 1 377 ? -33.002 -11.654 -53.548 1.00 18.08 ? 361 LYS A C 1 ATOM 2678 O O . LYS A 1 377 ? -33.722 -12.051 -52.633 1.00 17.27 ? 361 LYS A O 1 ATOM 2679 C CB . LYS A 1 377 ? -33.837 -12.139 -55.850 1.00 21.25 ? 361 LYS A CB 1 ATOM 2680 C CG . LYS A 1 377 ? -34.708 -13.290 -55.368 1.00 20.64 ? 361 LYS A CG 1 ATOM 2681 C CD . LYS A 1 377 ? -34.775 -14.404 -56.402 1.00 15.88 ? 361 LYS A CD 1 ATOM 2682 C CE . LYS A 1 377 ? -35.691 -15.534 -55.954 1.00 16.22 ? 361 LYS A CE 1 ATOM 2683 N NZ . LYS A 1 377 ? -35.124 -16.312 -54.818 1.00 21.86 ? 361 LYS A NZ 1 ATOM 2684 N N . GLU A 1 378 ? -31.677 -11.728 -53.506 1.00 22.42 ? 362 GLU A N 1 ATOM 2685 C CA . GLU A 1 378 ? -30.993 -12.396 -52.405 1.00 21.55 ? 362 GLU A CA 1 ATOM 2686 C C . GLU A 1 378 ? -30.722 -11.456 -51.232 1.00 19.49 ? 362 GLU A C 1 ATOM 2687 O O . GLU A 1 378 ? -30.258 -11.891 -50.179 1.00 27.50 ? 362 GLU A O 1 ATOM 2688 C CB . GLU A 1 378 ? -29.680 -13.012 -52.894 1.00 25.86 ? 362 GLU A CB 1 ATOM 2689 C CG . GLU A 1 378 ? -29.384 -14.377 -52.290 1.00 27.99 ? 362 GLU A CG 1 ATOM 2690 C CD . GLU A 1 378 ? -30.370 -15.439 -52.736 1.00 25.09 ? 362 GLU A CD 1 ATOM 2691 O OE1 . GLU A 1 378 ? -30.905 -16.159 -51.867 1.00 28.95 ? 362 GLU A OE1 1 ATOM 2692 O OE2 . GLU A 1 378 ? -30.609 -15.554 -53.956 1.00 19.25 ? 362 GLU A OE2 1 ATOM 2693 N N . LYS A 1 379 ? -31.015 -10.172 -51.411 1.00 22.97 ? 363 LYS A N 1 ATOM 2694 C CA . LYS A 1 379 ? -30.829 -9.195 -50.344 1.00 18.70 ? 363 LYS A CA 1 ATOM 2695 C C . LYS A 1 379 ? -32.161 -8.901 -49.662 1.00 16.21 ? 363 LYS A C 1 ATOM 2696 O O . LYS A 1 379 ? -33.141 -8.576 -50.333 1.00 16.30 ? 363 LYS A O 1 ATOM 2697 C CB . LYS A 1 379 ? -30.250 -7.894 -50.900 1.00 21.09 ? 363 LYS A CB 1 ATOM 2698 C CG . LYS A 1 379 ? -28.992 -8.070 -51.729 1.00 20.78 ? 363 LYS A CG 1 ATOM 2699 C CD . LYS A 1 379 ? -27.865 -8.691 -50.930 1.00 18.33 ? 363 LYS A CD 1 ATOM 2700 C CE . LYS A 1 379 ? -26.564 -8.680 -51.720 1.00 29.88 ? 363 LYS A CE 1 ATOM 2701 N NZ . LYS A 1 379 ? -26.059 -7.299 -51.970 1.00 37.33 ? 363 LYS A NZ 1 ATOM 2702 N N . PRO A 1 380 ? -32.206 -9.019 -48.325 1.00 21.43 ? 364 PRO A N 1 ATOM 2703 C CA . PRO A 1 380 ? -33.423 -8.644 -47.597 1.00 17.71 ? 364 PRO A CA 1 ATOM 2704 C C . PRO A 1 380 ? -33.685 -7.145 -47.694 1.00 11.97 ? 364 PRO A C 1 ATOM 2705 O O . PRO A 1 380 ? -32.739 -6.372 -47.847 1.00 14.71 ? 364 PRO A O 1 ATOM 2706 C CB . PRO A 1 380 ? -33.109 -9.041 -46.148 1.00 18.04 ? 364 PRO A CB 1 ATOM 2707 C CG . PRO A 1 380 ? -31.976 -10.008 -46.240 1.00 15.34 ? 364 PRO A CG 1 ATOM 2708 C CD . PRO A 1 380 ? -31.182 -9.583 -47.431 1.00 18.02 ? 364 PRO A CD 1 ATOM 2709 N N . VAL A 1 381 ? -34.949 -6.744 -47.608 1.00 10.94 ? 365 VAL A N 1 ATOM 2710 C CA . VAL A 1 381 ? -35.317 -5.338 -47.743 1.00 10.86 ? 365 VAL A CA 1 ATOM 2711 C C . VAL A 1 381 ? -35.955 -4.805 -46.465 1.00 7.89 ? 365 VAL A C 1 ATOM 2712 O O . VAL A 1 381 ? -36.958 -5.336 -45.990 1.00 7.69 ? 365 VAL A O 1 ATOM 2713 C CB . VAL A 1 381 ? -36.295 -5.127 -48.914 1.00 10.59 ? 365 VAL A CB 1 ATOM 2714 C CG1 . VAL A 1 381 ? -36.649 -3.653 -49.054 1.00 9.63 ? 365 VAL A CG1 1 ATOM 2715 C CG2 . VAL A 1 381 ? -35.697 -5.665 -50.207 1.00 9.25 ? 365 VAL A CG2 1 ATOM 2716 N N . ASN A 1 382 ? -35.364 -3.749 -45.916 1.00 10.44 ? 366 ASN A N 1 ATOM 2717 C CA . ASN A 1 382 ? -35.885 -3.109 -44.715 1.00 11.78 ? 366 ASN A CA 1 ATOM 2718 C C . ASN A 1 382 ? -37.040 -2.168 -45.044 1.00 14.43 ? 366 ASN A C 1 ATOM 2719 O O . ASN A 1 382 ? -36.959 -1.378 -45.985 1.00 18.87 ? 366 ASN A O 1 ATOM 2720 C CB . ASN A 1 382 ? -34.772 -2.340 -44.001 1.00 8.44 ? 366 ASN A CB 1 ATOM 2721 C CG . ASN A 1 382 ? -33.739 -3.258 -43.374 1.00 11.21 ? 366 ASN A CG 1 ATOM 2722 O OD1 . ASN A 1 382 ? -34.081 -4.173 -42.624 1.00 12.40 ? 366 ASN A OD1 1 ATOM 2723 N ND2 . ASN A 1 382 ? -32.469 -3.023 -43.684 1.00 12.33 ? 366 ASN A ND2 1 ATOM 2724 N N . ILE A 1 383 ? -38.115 -2.262 -44.267 1.00 13.16 ? 367 ILE A N 1 ATOM 2725 C CA . ILE A 1 383 ? -39.293 -1.428 -44.478 1.00 12.61 ? 367 ILE A CA 1 ATOM 2726 C C . ILE A 1 383 ? -39.761 -0.796 -43.173 1.00 12.90 ? 367 ILE A C 1 ATOM 2727 O O . ILE A 1 383 ? -40.185 -1.495 -42.254 1.00 20.14 ? 367 ILE A O 1 ATOM 2728 C CB . ILE A 1 383 ? -40.459 -2.242 -45.064 1.00 14.66 ? 367 ILE A CB 1 ATOM 2729 C CG1 . ILE A 1 383 ? -40.080 -2.800 -46.436 1.00 7.56 ? 367 ILE A CG1 1 ATOM 2730 C CG2 . ILE A 1 383 ? -41.700 -1.372 -45.180 1.00 10.12 ? 367 ILE A CG2 1 ATOM 2731 C CD1 . ILE A 1 383 ? -41.054 -3.829 -46.965 1.00 9.17 ? 367 ILE A CD1 1 ATOM 2732 N N . GLU A 1 384 ? -39.690 0.530 -43.101 1.00 13.31 ? 368 GLU A N 1 ATOM 2733 C CA . GLU A 1 384 ? -40.201 1.257 -41.946 1.00 13.49 ? 368 GLU A CA 1 ATOM 2734 C C . GLU A 1 384 ? -41.603 1.770 -42.244 1.00 8.60 ? 368 GLU A C 1 ATOM 2735 O O . GLU A 1 384 ? -41.865 2.295 -43.326 1.00 12.42 ? 368 GLU A O 1 ATOM 2736 C CB . GLU A 1 384 ? -39.287 2.431 -41.590 1.00 13.86 ? 368 GLU A CB 1 ATOM 2737 C CG . GLU A 1 384 ? -37.838 2.041 -41.347 1.00 17.73 ? 368 GLU A CG 1 ATOM 2738 C CD . GLU A 1 384 ? -37.033 3.156 -40.707 1.00 27.32 ? 368 GLU A CD 1 ATOM 2739 O OE1 . GLU A 1 384 ? -37.641 4.154 -40.266 1.00 24.35 ? 368 GLU A OE1 1 ATOM 2740 O OE2 . GLU A 1 384 ? -35.790 3.036 -40.647 1.00 31.84 ? 368 GLU A OE2 1 ATOM 2741 N N . ALA A 1 385 ? -42.503 1.612 -41.280 1.00 7.90 ? 369 ALA A N 1 ATOM 2742 C CA . ALA A 1 385 ? -43.873 2.085 -41.429 1.00 9.81 ? 369 ALA A CA 1 ATOM 2743 C C . ALA A 1 385 ? -44.402 2.579 -40.088 1.00 9.18 ? 369 ALA A C 1 ATOM 2744 O O . ALA A 1 385 ? -43.845 2.263 -39.036 1.00 9.70 ? 369 ALA A O 1 ATOM 2745 C CB . ALA A 1 385 ? -44.763 0.978 -41.985 1.00 8.84 ? 369 ALA A CB 1 ATOM 2746 N N . GLU A 1 386 ? -45.475 3.360 -40.136 1.00 11.15 ? 370 GLU A N 1 ATOM 2747 C CA . GLU A 1 386 ? -46.055 3.956 -38.939 1.00 7.24 ? 370 GLU A CA 1 ATOM 2748 C C . GLU A 1 386 ? -47.502 3.504 -38.770 1.00 8.98 ? 370 GLU A C 1 ATOM 2749 O O . GLU A 1 386 ? -48.422 4.167 -39.249 1.00 14.48 ? 370 GLU A O 1 ATOM 2750 C CB . GLU A 1 386 ? -45.987 5.481 -39.036 1.00 10.04 ? 370 GLU A CB 1 ATOM 2751 C CG . GLU A 1 386 ? -46.565 6.208 -37.834 1.00 12.12 ? 370 GLU A CG 1 ATOM 2752 C CD . GLU A 1 386 ? -46.368 7.709 -37.909 1.00 15.89 ? 370 GLU A CD 1 ATOM 2753 O OE1 . GLU A 1 386 ? -46.651 8.398 -36.907 1.00 16.93 ? 370 GLU A OE1 1 ATOM 2754 O OE2 . GLU A 1 386 ? -45.934 8.200 -38.972 1.00 12.27 ? 370 GLU A OE2 1 ATOM 2755 N N . PRO A 1 387 ? -47.708 2.367 -38.086 1.00 13.38 ? 371 PRO A N 1 ATOM 2756 C CA . PRO A 1 387 ? -49.045 1.794 -37.887 1.00 5.69 ? 371 PRO A CA 1 ATOM 2757 C C . PRO A 1 387 ? -49.984 2.735 -37.143 1.00 7.39 ? 371 PRO A C 1 ATOM 2758 O O . PRO A 1 387 ? -49.517 3.597 -36.398 1.00 7.55 ? 371 PRO A O 1 ATOM 2759 C CB . PRO A 1 387 ? -48.774 0.556 -37.024 1.00 4.68 ? 371 PRO A CB 1 ATOM 2760 C CG . PRO A 1 387 ? -47.343 0.241 -37.220 1.00 7.98 ? 371 PRO A CG 1 ATOM 2761 C CD . PRO A 1 387 ? -46.660 1.546 -37.456 1.00 11.18 ? 371 PRO A CD 1 ATOM 2762 N N . PRO A 1 388 ? -51.301 2.573 -37.344 1.00 7.24 ? 372 PRO A N 1 ATOM 2763 C CA . PRO A 1 388 ? -52.270 3.305 -36.525 1.00 3.94 ? 372 PRO A CA 1 ATOM 2764 C C . PRO A 1 388 ? -52.147 2.877 -35.073 1.00 4.66 ? 372 PRO A C 1 ATOM 2765 O O . PRO A 1 388 ? -51.540 1.842 -34.801 1.00 8.96 ? 372 PRO A O 1 ATOM 2766 C CB . PRO A 1 388 ? -53.624 2.852 -37.081 1.00 4.59 ? 372 PRO A CB 1 ATOM 2767 C CG . PRO A 1 388 ? -53.338 2.283 -38.424 1.00 8.33 ? 372 PRO A CG 1 ATOM 2768 C CD . PRO A 1 388 ? -51.952 1.734 -38.362 1.00 6.68 ? 372 PRO A CD 1 ATOM 2769 N N . PHE A 1 389 ? -52.706 3.652 -34.154 1.00 3.76 ? 373 PHE A N 1 ATOM 2770 C CA . PHE A 1 389 ? -52.750 3.233 -32.763 1.00 3.16 ? 373 PHE A CA 1 ATOM 2771 C C . PHE A 1 389 ? -53.822 2.164 -32.589 1.00 7.25 ? 373 PHE A C 1 ATOM 2772 O O . PHE A 1 389 ? -54.873 2.217 -33.227 1.00 10.35 ? 373 PHE A O 1 ATOM 2773 C CB . PHE A 1 389 ? -53.034 4.418 -31.846 1.00 7.24 ? 373 PHE A CB 1 ATOM 2774 C CG . PHE A 1 389 ? -51.853 5.326 -31.642 1.00 5.80 ? 373 PHE A CG 1 ATOM 2775 C CD1 . PHE A 1 389 ? -50.936 5.073 -30.635 1.00 4.34 ? 373 PHE A CD1 1 ATOM 2776 C CD2 . PHE A 1 389 ? -51.665 6.434 -32.450 1.00 4.11 ? 373 PHE A CD2 1 ATOM 2777 C CE1 . PHE A 1 389 ? -49.851 5.907 -30.441 1.00 5.58 ? 373 PHE A CE1 1 ATOM 2778 C CE2 . PHE A 1 389 ? -50.582 7.272 -32.259 1.00 3.16 ? 373 PHE A CE2 1 ATOM 2779 C CZ . PHE A 1 389 ? -49.675 7.008 -31.254 1.00 4.63 ? 373 PHE A CZ 1 ATOM 2780 N N . GLY A 1 390 ? -53.552 1.195 -31.722 1.00 15.23 ? 374 GLY A N 1 ATOM 2781 C CA . GLY A 1 390 ? -54.458 0.080 -31.520 1.00 7.40 ? 374 GLY A CA 1 ATOM 2782 C C . GLY A 1 390 ? -54.114 -1.078 -32.436 1.00 7.69 ? 374 GLY A C 1 ATOM 2783 O O . GLY A 1 390 ? -52.961 -1.242 -32.833 1.00 9.97 ? 374 GLY A O 1 ATOM 2784 N N . GLU A 1 391 ? -55.118 -1.879 -32.778 1.00 11.80 ? 375 GLU A N 1 ATOM 2785 C CA . GLU A 1 391 ? -54.920 -3.024 -33.658 1.00 9.04 ? 375 GLU A CA 1 ATOM 2786 C C . GLU A 1 391 ? -54.865 -2.585 -35.117 1.00 15.89 ? 375 GLU A C 1 ATOM 2787 O O . GLU A 1 391 ? -55.474 -1.587 -35.502 1.00 15.63 ? 375 GLU A O 1 ATOM 2788 C CB . GLU A 1 391 ? -56.041 -4.048 -33.463 1.00 12.97 ? 375 GLU A CB 1 ATOM 2789 C CG . GLU A 1 391 ? -55.677 -5.207 -32.547 1.00 15.98 ? 375 GLU A CG 1 ATOM 2790 C CD . GLU A 1 391 ? -54.926 -6.315 -33.265 1.00 19.06 ? 375 GLU A CD 1 ATOM 2791 O OE1 . GLU A 1 391 ? -54.191 -7.067 -32.591 1.00 14.37 ? 375 GLU A OE1 1 ATOM 2792 O OE2 . GLU A 1 391 ? -55.075 -6.438 -34.499 1.00 17.18 ? 375 GLU A OE2 1 ATOM 2793 N N . SER A 1 392 ? -54.135 -3.346 -35.925 1.00 12.21 ? 376 SER A N 1 ATOM 2794 C CA . SER A 1 392 ? -54.000 -3.051 -37.347 1.00 11.51 ? 376 SER A CA 1 ATOM 2795 C C . SER A 1 392 ? -53.399 -4.248 -38.073 1.00 13.47 ? 376 SER A C 1 ATOM 2796 O O . SER A 1 392 ? -53.158 -5.291 -37.466 1.00 15.14 ? 376 SER A O 1 ATOM 2797 C CB . SER A 1 392 ? -53.122 -1.815 -37.560 1.00 15.86 ? 376 SER A CB 1 ATOM 2798 O OG . SER A 1 392 ? -51.796 -2.042 -37.120 1.00 15.65 ? 376 SER A OG 1 ATOM 2799 N N . TYR A 1 393 ? -53.172 -4.097 -39.375 1.00 18.72 ? 377 TYR A N 1 ATOM 2800 C CA . TYR A 1 393 ? -52.570 -5.159 -40.175 1.00 12.38 ? 377 TYR A CA 1 ATOM 2801 C C . TYR A 1 393 ? -51.589 -4.601 -41.200 1.00 12.13 ? 377 TYR A C 1 ATOM 2802 O O . TYR A 1 393 ? -51.908 -3.667 -41.934 1.00 16.14 ? 377 TYR A O 1 ATOM 2803 C CB . TYR A 1 393 ? -53.653 -5.959 -40.899 1.00 16.37 ? 377 TYR A CB 1 ATOM 2804 C CG . TYR A 1 393 ? -54.707 -6.543 -39.987 1.00 16.83 ? 377 TYR A CG 1 ATOM 2805 C CD1 . TYR A 1 393 ? -54.517 -7.773 -39.374 1.00 18.66 ? 377 TYR A CD1 1 ATOM 2806 C CD2 . TYR A 1 393 ? -55.896 -5.866 -39.744 1.00 23.11 ? 377 TYR A CD2 1 ATOM 2807 C CE1 . TYR A 1 393 ? -55.476 -8.311 -38.541 1.00 22.36 ? 377 TYR A CE1 1 ATOM 2808 C CE2 . TYR A 1 393 ? -56.862 -6.398 -38.913 1.00 28.57 ? 377 TYR A CE2 1 ATOM 2809 C CZ . TYR A 1 393 ? -56.647 -7.620 -38.314 1.00 24.46 ? 377 TYR A CZ 1 ATOM 2810 O OH . TYR A 1 393 ? -57.606 -8.155 -37.484 1.00 41.69 ? 377 TYR A OH 1 ATOM 2811 N N . ILE A 1 394 ? -50.396 -5.186 -41.244 1.00 14.29 ? 378 ILE A N 1 ATOM 2812 C CA . ILE A 1 394 ? -49.398 -4.842 -42.248 1.00 14.64 ? 378 ILE A CA 1 ATOM 2813 C C . ILE A 1 394 ? -49.453 -5.870 -43.368 1.00 18.64 ? 378 ILE A C 1 ATOM 2814 O O . ILE A 1 394 ? -49.619 -7.063 -43.115 1.00 23.43 ? 378 ILE A O 1 ATOM 2815 C CB . ILE A 1 394 ? -47.983 -4.836 -41.648 1.00 16.58 ? 378 ILE A CB 1 ATOM 2816 C CG1 . ILE A 1 394 ? -47.873 -3.760 -40.567 1.00 18.47 ? 378 ILE A CG1 1 ATOM 2817 C CG2 . ILE A 1 394 ? -46.945 -4.590 -42.732 1.00 18.10 ? 378 ILE A CG2 1 ATOM 2818 C CD1 . ILE A 1 394 ? -46.906 -4.105 -39.453 1.00 16.34 ? 378 ILE A CD1 1 ATOM 2819 N N . VAL A 1 395 ? -49.313 -5.412 -44.607 1.00 25.85 ? 379 VAL A N 1 ATOM 2820 C CA . VAL A 1 395 ? -49.401 -6.304 -45.756 1.00 20.14 ? 379 VAL A CA 1 ATOM 2821 C C . VAL A 1 395 ? -48.332 -5.986 -46.795 1.00 14.32 ? 379 VAL A C 1 ATOM 2822 O O . VAL A 1 395 ? -48.334 -4.911 -47.395 1.00 17.96 ? 379 VAL A O 1 ATOM 2823 C CB . VAL A 1 395 ? -50.782 -6.219 -46.426 1.00 16.02 ? 379 VAL A CB 1 ATOM 2824 C CG1 . VAL A 1 395 ? -50.908 -7.272 -47.513 1.00 16.46 ? 379 VAL A CG1 1 ATOM 2825 C CG2 . VAL A 1 395 ? -51.881 -6.392 -45.394 1.00 20.53 ? 379 VAL A CG2 1 ATOM 2826 N N . VAL A 1 396 ? -47.421 -6.932 -46.998 1.00 11.14 ? 380 VAL A N 1 ATOM 2827 C CA . VAL A 1 396 ? -46.386 -6.806 -48.017 1.00 15.98 ? 380 VAL A CA 1 ATOM 2828 C C . VAL A 1 396 ? -46.567 -7.903 -49.062 1.00 14.94 ? 380 VAL A C 1 ATOM 2829 O O . VAL A 1 396 ? -46.716 -9.076 -48.725 1.00 13.29 ? 380 VAL A O 1 ATOM 2830 C CB . VAL A 1 396 ? -44.966 -6.872 -47.406 1.00 13.21 ? 380 VAL A CB 1 ATOM 2831 C CG1 . VAL A 1 396 ? -44.979 -7.620 -46.080 1.00 9.23 ? 380 VAL A CG1 1 ATOM 2832 C CG2 . VAL A 1 396 ? -43.984 -7.508 -48.384 1.00 14.07 ? 380 VAL A CG2 1 ATOM 2833 N N . GLY A 1 397 ? -46.551 -7.511 -50.332 1.00 6.84 ? 381 GLY A N 1 ATOM 2834 C CA . GLY A 1 397 ? -46.866 -8.421 -51.418 1.00 14.43 ? 381 GLY A CA 1 ATOM 2835 C C . GLY A 1 397 ? -48.287 -8.189 -51.894 1.00 15.02 ? 381 GLY A C 1 ATOM 2836 O O . GLY A 1 397 ? -49.038 -7.442 -51.267 1.00 16.54 ? 381 GLY A O 1 ATOM 2837 N N . ALA A 1 398 ? -48.661 -8.823 -53.001 1.00 13.54 ? 382 ALA A N 1 ATOM 2838 C CA . ALA A 1 398 ? -49.980 -8.613 -53.591 1.00 15.38 ? 382 ALA A CA 1 ATOM 2839 C C . ALA A 1 398 ? -50.767 -9.911 -53.737 1.00 18.51 ? 382 ALA A C 1 ATOM 2840 O O . ALA A 1 398 ? -50.193 -10.979 -53.954 1.00 17.24 ? 382 ALA A O 1 ATOM 2841 C CB . ALA A 1 398 ? -49.839 -7.942 -54.942 1.00 20.47 ? 382 ALA A CB 1 ATOM 2842 N N . GLY A 1 399 ? -52.087 -9.804 -53.616 1.00 26.47 ? 383 GLY A N 1 ATOM 2843 C CA . GLY A 1 399 ? -52.976 -10.927 -53.852 1.00 26.02 ? 383 GLY A CA 1 ATOM 2844 C C . GLY A 1 399 ? -53.060 -11.899 -52.692 1.00 28.77 ? 383 GLY A C 1 ATOM 2845 O O . GLY A 1 399 ? -53.100 -11.499 -51.528 1.00 32.21 ? 383 GLY A O 1 ATOM 2846 N N . GLU A 1 400 ? -53.093 -13.187 -53.023 1.00 29.93 ? 384 GLU A N 1 ATOM 2847 C CA . GLU A 1 400 ? -53.180 -14.249 -52.028 1.00 31.68 ? 384 GLU A CA 1 ATOM 2848 C C . GLU A 1 400 ? -51.781 -14.585 -51.538 1.00 24.89 ? 384 GLU A C 1 ATOM 2849 O O . GLU A 1 400 ? -51.602 -15.215 -50.496 1.00 29.14 ? 384 GLU A O 1 ATOM 2850 C CB . GLU A 1 400 ? -53.814 -15.499 -52.640 1.00 38.35 ? 384 GLU A CB 1 ATOM 2851 C CG . GLU A 1 400 ? -55.013 -15.222 -53.544 1.00 34.54 ? 384 GLU A CG 1 ATOM 2852 C CD . GLU A 1 400 ? -55.311 -16.369 -54.491 1.00 36.26 ? 384 GLU A CD 1 ATOM 2853 O OE1 . GLU A 1 400 ? -54.852 -17.499 -54.221 1.00 24.00 ? 384 GLU A OE1 1 ATOM 2854 O OE2 . GLU A 1 400 ? -55.995 -16.137 -55.511 1.00 49.10 ? 384 GLU A OE2 1 ATOM 2855 N N . LYS A 1 401 ? -50.790 -14.150 -52.308 1.00 32.70 ? 385 LYS A N 1 ATOM 2856 C CA . LYS A 1 401 ? -49.390 -14.387 -51.996 1.00 28.98 ? 385 LYS A CA 1 ATOM 2857 C C . LYS A 1 401 ? -48.861 -13.336 -51.020 1.00 32.89 ? 385 LYS A C 1 ATOM 2858 O O . LYS A 1 401 ? -47.651 -13.174 -50.864 1.00 35.48 ? 385 LYS A O 1 ATOM 2859 C CB . LYS A 1 401 ? -48.580 -14.350 -53.294 1.00 26.11 ? 385 LYS A CB 1 ATOM 2860 C CG . LYS A 1 401 ? -47.130 -14.754 -53.139 1.00 23.68 ? 385 LYS A CG 1 ATOM 2861 C CD . LYS A 1 401 ? -46.825 -16.069 -53.847 1.00 32.26 ? 385 LYS A CD 1 ATOM 2862 C CE . LYS A 1 401 ? -46.961 -15.952 -55.358 1.00 29.68 ? 385 LYS A CE 1 ATOM 2863 N NZ . LYS A 1 401 ? -46.340 -17.113 -56.056 1.00 29.15 ? 385 LYS A NZ 1 ATOM 2864 N N . ALA A 1 402 ? -49.772 -12.629 -50.358 1.00 29.43 ? 386 ALA A N 1 ATOM 2865 C CA . ALA A 1 402 ? -49.398 -11.511 -49.498 1.00 22.03 ? 386 ALA A CA 1 ATOM 2866 C C . ALA A 1 402 ? -49.112 -11.941 -48.061 1.00 18.58 ? 386 ALA A C 1 ATOM 2867 O O . ALA A 1 402 ? -49.780 -12.819 -47.516 1.00 21.79 ? 386 ALA A O 1 ATOM 2868 C CB . ALA A 1 402 ? -50.489 -10.457 -49.520 1.00 20.22 ? 386 ALA A CB 1 ATOM 2869 N N . LEU A 1 403 ? -48.110 -11.304 -47.460 1.00 19.87 ? 387 LEU A N 1 ATOM 2870 C CA . LEU A 1 403 ? -47.749 -11.543 -46.068 1.00 13.90 ? 387 LEU A CA 1 ATOM 2871 C C . LEU A 1 403 ? -48.609 -10.666 -45.164 1.00 16.87 ? 387 LEU A C 1 ATOM 2872 O O . LEU A 1 403 ? -48.473 -9.444 -45.170 1.00 23.42 ? 387 LEU A O 1 ATOM 2873 C CB . LEU A 1 403 ? -46.272 -11.212 -45.851 1.00 15.54 ? 387 LEU A CB 1 ATOM 2874 C CG . LEU A 1 403 ? -45.375 -12.299 -45.257 1.00 20.63 ? 387 LEU A CG 1 ATOM 2875 C CD1 . LEU A 1 403 ? -43.935 -11.811 -45.226 1.00 16.86 ? 387 LEU A CD1 1 ATOM 2876 C CD2 . LEU A 1 403 ? -45.834 -12.698 -43.864 1.00 22.67 ? 387 LEU A CD2 1 ATOM 2877 N N . LYS A 1 404 ? -49.486 -11.291 -44.386 1.00 23.06 ? 388 LYS A N 1 ATOM 2878 C CA . LYS A 1 404 ? -50.419 -10.555 -43.538 1.00 21.17 ? 388 LYS A CA 1 ATOM 2879 C C . LYS A 1 404 ? -50.029 -10.673 -42.067 1.00 24.52 ? 388 LYS A C 1 ATOM 2880 O O . LYS A 1 404 ? -49.907 -11.776 -41.535 1.00 21.01 ? 388 LYS A O 1 ATOM 2881 C CB . LYS A 1 404 ? -51.842 -11.072 -43.758 1.00 24.99 ? 388 LYS A CB 1 ATOM 2882 C CG . LYS A 1 404 ? -52.932 -10.220 -43.132 1.00 32.01 ? 388 LYS A CG 1 ATOM 2883 C CD . LYS A 1 404 ? -54.278 -10.515 -43.778 1.00 41.98 ? 388 LYS A CD 1 ATOM 2884 C CE . LYS A 1 404 ? -55.440 -10.059 -42.914 1.00 46.66 ? 388 LYS A CE 1 ATOM 2885 N NZ . LYS A 1 404 ? -56.747 -10.399 -43.541 1.00 48.76 ? 388 LYS A NZ 1 ATOM 2886 N N . LEU A 1 405 ? -49.835 -9.528 -41.418 1.00 29.57 ? 389 LEU A N 1 ATOM 2887 C CA . LEU A 1 405 ? -49.390 -9.492 -40.029 1.00 20.34 ? 389 LEU A CA 1 ATOM 2888 C C . LEU A 1 405 ? -50.261 -8.550 -39.207 1.00 14.50 ? 389 LEU A C 1 ATOM 2889 O O . LEU A 1 405 ? -50.502 -7.414 -39.609 1.00 22.61 ? 389 LEU A O 1 ATOM 2890 C CB . LEU A 1 405 ? -47.934 -9.029 -39.963 1.00 20.84 ? 389 LEU A CB 1 ATOM 2891 C CG . LEU A 1 405 ? -47.022 -9.764 -38.979 1.00 27.78 ? 389 LEU A CG 1 ATOM 2892 C CD1 . LEU A 1 405 ? -45.646 -9.955 -39.595 1.00 31.53 ? 389 LEU A CD1 1 ATOM 2893 C CD2 . LEU A 1 405 ? -46.915 -9.011 -37.662 1.00 17.78 ? 389 LEU A CD2 1 ATOM 2894 N N . SER A 1 406 ? -50.727 -9.025 -38.055 1.00 18.44 ? 390 SER A N 1 ATOM 2895 C CA . SER A 1 406 ? -51.546 -8.211 -37.160 1.00 15.30 ? 390 SER A CA 1 ATOM 2896 C C . SER A 1 406 ? -50.667 -7.527 -36.118 1.00 11.55 ? 390 SER A C 1 ATOM 2897 O O . SER A 1 406 ? -49.826 -8.168 -35.490 1.00 13.63 ? 390 SER A O 1 ATOM 2898 C CB . SER A 1 406 ? -52.612 -9.071 -36.475 1.00 18.77 ? 390 SER A CB 1 ATOM 2899 O OG . SER A 1 406 ? -52.028 -10.095 -35.688 1.00 31.51 ? 390 SER A OG 1 ATOM 2900 N N . TRP A 1 407 ? -50.872 -6.226 -35.934 1.00 14.91 ? 391 TRP A N 1 ATOM 2901 C CA . TRP A 1 407 ? -50.022 -5.429 -35.056 1.00 13.26 ? 391 TRP A CA 1 ATOM 2902 C C . TRP A 1 407 ? -50.854 -4.602 -34.081 1.00 8.69 ? 391 TRP A C 1 ATOM 2903 O O . TRP A 1 407 ? -51.858 -4.004 -34.465 1.00 14.06 ? 391 TRP A O 1 ATOM 2904 C CB . TRP A 1 407 ? -49.144 -4.498 -35.897 1.00 8.49 ? 391 TRP A CB 1 ATOM 2905 C CG . TRP A 1 407 ? -48.118 -3.747 -35.104 1.00 10.02 ? 391 TRP A CG 1 ATOM 2906 C CD1 . TRP A 1 407 ? -48.141 -2.421 -34.779 1.00 10.89 ? 391 TRP A CD1 1 ATOM 2907 C CD2 . TRP A 1 407 ? -46.918 -4.279 -34.532 1.00 10.08 ? 391 TRP A CD2 1 ATOM 2908 N NE1 . TRP A 1 407 ? -47.028 -2.095 -34.042 1.00 9.94 ? 391 TRP A NE1 1 ATOM 2909 C CE2 . TRP A 1 407 ? -46.261 -3.220 -33.875 1.00 12.07 ? 391 TRP A CE2 1 ATOM 2910 C CE3 . TRP A 1 407 ? -46.335 -5.550 -34.510 1.00 11.20 ? 391 TRP A CE3 1 ATOM 2911 C CZ2 . TRP A 1 407 ? -45.050 -3.390 -33.209 1.00 16.54 ? 391 TRP A CZ2 1 ATOM 2912 C CZ3 . TRP A 1 407 ? -45.133 -5.718 -33.847 1.00 12.84 ? 391 TRP A CZ3 1 ATOM 2913 C CH2 . TRP A 1 407 ? -44.503 -4.644 -33.205 1.00 8.26 ? 391 TRP A CH2 1 ATOM 2914 N N . PHE A 1 408 ? -50.437 -4.575 -32.817 1.00 6.69 ? 392 PHE A N 1 ATOM 2915 C CA . PHE A 1 408 ? -51.057 -3.694 -31.832 1.00 8.37 ? 392 PHE A CA 1 ATOM 2916 C C . PHE A 1 408 ? -50.079 -2.602 -31.416 1.00 6.74 ? 392 PHE A C 1 ATOM 2917 O O . PHE A 1 408 ? -48.942 -2.882 -31.036 1.00 7.45 ? 392 PHE A O 1 ATOM 2918 C CB . PHE A 1 408 ? -51.525 -4.468 -30.597 1.00 7.98 ? 392 PHE A CB 1 ATOM 2919 C CG . PHE A 1 408 ? -52.254 -3.613 -29.599 1.00 4.15 ? 392 PHE A CG 1 ATOM 2920 C CD1 . PHE A 1 408 ? -53.568 -3.242 -29.822 1.00 6.67 ? 392 PHE A CD1 1 ATOM 2921 C CD2 . PHE A 1 408 ? -51.624 -3.171 -28.448 1.00 6.39 ? 392 PHE A CD2 1 ATOM 2922 C CE1 . PHE A 1 408 ? -54.244 -2.452 -28.916 1.00 5.26 ? 392 PHE A CE1 1 ATOM 2923 C CE2 . PHE A 1 408 ? -52.297 -2.379 -27.536 1.00 8.38 ? 392 PHE A CE2 1 ATOM 2924 C CZ . PHE A 1 408 ? -53.609 -2.020 -27.771 1.00 4.78 ? 392 PHE A CZ 1 ATOM 2925 N N . LYS A 1 409 ? -50.535 -1.357 -31.484 1.00 10.30 ? 393 LYS A N 1 ATOM 2926 C CA . LYS A 1 409 ? -49.695 -0.207 -31.181 1.00 5.65 ? 393 LYS A CA 1 ATOM 2927 C C . LYS A 1 409 ? -50.252 0.548 -29.980 1.00 10.40 ? 393 LYS A C 1 ATOM 2928 O O . LYS A 1 409 ? -51.379 1.043 -30.007 1.00 11.13 ? 393 LYS A O 1 ATOM 2929 C CB . LYS A 1 409 ? -49.618 0.708 -32.401 1.00 7.03 ? 393 LYS A CB 1 ATOM 2930 C CG . LYS A 1 409 ? -48.842 1.997 -32.190 1.00 9.50 ? 393 LYS A CG 1 ATOM 2931 C CD . LYS A 1 409 ? -48.714 2.757 -33.499 1.00 5.67 ? 393 LYS A CD 1 ATOM 2932 C CE . LYS A 1 409 ? -47.799 3.953 -33.368 1.00 4.13 ? 393 LYS A CE 1 ATOM 2933 N NZ . LYS A 1 409 ? -47.499 4.537 -34.702 1.00 7.44 ? 393 LYS A NZ 1 ATOM 2934 N N . LYS A 1 410 ? -49.455 0.619 -28.920 1.00 11.08 ? 394 LYS A N 1 ATOM 2935 C CA . LYS A 1 410 ? -49.883 1.237 -27.671 1.00 8.70 ? 394 LYS A CA 1 ATOM 2936 C C . LYS A 1 410 ? -49.719 2.753 -27.709 1.00 14.57 ? 394 LYS A C 1 ATOM 2937 O O . LYS A 1 410 ? -48.835 3.276 -28.389 1.00 17.60 ? 394 LYS A O 1 ATOM 2938 C CB . LYS A 1 410 ? -49.089 0.660 -26.493 1.00 18.87 ? 394 LYS A CB 1 ATOM 2939 C CG . LYS A 1 410 ? -47.579 0.678 -26.689 1.00 25.72 ? 394 LYS A CG 1 ATOM 2940 C CD . LYS A 1 410 ? -46.845 0.149 -25.473 1.00 35.00 ? 394 LYS A CD 1 ATOM 2941 C CE . LYS A 1 410 ? -45.342 0.188 -25.697 1.00 53.69 ? 394 LYS A CE 1 ATOM 2942 N NZ . LYS A 1 410 ? -44.588 -0.628 -24.707 1.00 61.15 ? 394 LYS A NZ 1 ATOM 2943 N N . GLY A 1 411 ? -50.574 3.452 -26.970 1.00 9.88 ? 395 GLY A N 1 ATOM 2944 C CA . GLY A 1 411 ? -50.501 4.898 -26.884 1.00 7.13 ? 395 GLY A CA 1 ATOM 2945 C C . GLY A 1 411 ? -49.121 5.359 -26.456 1.00 11.23 ? 395 GLY A C 1 ATOM 2946 O O . GLY A 1 411 ? -48.334 4.576 -25.926 1.00 14.25 ? 395 GLY A O 1 ATOM 2947 N N . SER A 1 412 ? -48.833 6.638 -26.678 1.00 14.13 ? 396 SER A N 1 ATOM 2948 C CA . SER A 1 412 ? -47.518 7.193 -26.376 1.00 5.16 ? 396 SER A CA 1 ATOM 2949 C C . SER A 1 412 ? -47.272 7.259 -24.869 1.00 6.21 ? 396 SER A C 1 ATOM 2950 O O . SER A 1 412 ? -48.208 7.393 -24.080 1.00 9.77 ? 396 SER A O 1 ATOM 2951 C CB . SER A 1 412 ? -47.372 8.591 -26.987 1.00 10.93 ? 396 SER A CB 1 ATOM 2952 O OG . SER A 1 412 ? -47.413 8.556 -28.403 1.00 14.25 ? 396 SER A OG 1 ATOM 2953 N N . SER A 1 413 ? -46.002 7.173 -24.485 1.00 9.25 ? 397 SER A N 1 ATOM 2954 C CA . SER A 1 413 ? -45.597 7.257 -23.086 1.00 6.91 ? 397 SER A CA 1 ATOM 2955 C C . SER A 1 413 ? -44.260 7.980 -23.005 1.00 5.89 ? 397 SER A C 1 ATOM 2956 O O . SER A 1 413 ? -43.497 7.990 -23.969 1.00 9.55 ? 397 SER A O 1 ATOM 2957 C CB . SER A 1 413 ? -45.478 5.858 -22.473 1.00 7.46 ? 397 SER A CB 1 ATOM 2958 O OG . SER A 1 413 ? -44.990 5.918 -21.145 1.00 9.09 ? 397 SER A OG 1 ATOM 2959 N N . ILE A 1 414 ? -43.983 8.590 -21.856 1.00 8.40 ? 398 ILE A N 1 ATOM 2960 C CA . ILE A 1 414 ? -42.737 9.327 -21.663 1.00 7.48 ? 398 ILE A CA 1 ATOM 2961 C C . ILE A 1 414 ? -41.676 8.468 -20.982 1.00 7.36 ? 398 ILE A C 1 ATOM 2962 O O . ILE A 1 414 ? -40.531 8.892 -20.824 1.00 11.06 ? 398 ILE A O 1 ATOM 2963 C CB . ILE A 1 414 ? -42.953 10.612 -20.831 1.00 7.54 ? 398 ILE A CB 1 ATOM 2964 C CG1 . ILE A 1 414 ? -43.381 10.271 -19.399 1.00 5.89 ? 398 ILE A CG1 1 ATOM 2965 C CG2 . ILE A 1 414 ? -43.984 11.510 -21.505 1.00 7.01 ? 398 ILE A CG2 1 ATOM 2966 C CD1 . ILE A 1 414 ? -43.388 11.466 -18.464 1.00 3.82 ? 398 ILE A CD1 1 ATOM 2967 N N . GLY A 1 415 ? -42.060 7.259 -20.581 1.00 9.61 ? 399 GLY A N 1 ATOM 2968 C CA . GLY A 1 415 ? -41.138 6.347 -19.931 1.00 6.36 ? 399 GLY A CA 1 ATOM 2969 C C . GLY A 1 415 ? -41.741 5.702 -18.700 1.00 6.36 ? 399 GLY A C 1 ATOM 2970 O O . GLY A 1 415 ? -42.939 5.826 -18.446 1.00 5.68 ? 399 GLY A O 1 ATOM 2971 N N . LYS A 1 416 ? -40.902 5.018 -17.929 1.00 9.29 ? 400 LYS A N 1 ATOM 2972 C CA . LYS A 1 416 ? -41.360 4.302 -16.746 1.00 13.33 ? 400 LYS A CA 1 ATOM 2973 C C . LYS A 1 416 ? -40.905 4.996 -15.468 1.00 13.06 ? 400 LYS A C 1 ATOM 2974 O O . LYS A 1 416 ? -39.807 5.548 -15.404 1.00 13.70 ? 400 LYS A O 1 ATOM 2975 C CB . LYS A 1 416 ? -40.858 2.859 -16.782 1.00 14.06 ? 400 LYS A CB 1 ATOM 2976 C CG . LYS A 1 416 ? -41.362 2.085 -17.986 1.00 11.58 ? 400 LYS A CG 1 ATOM 2977 C CD . LYS A 1 416 ? -40.664 0.754 -18.125 1.00 15.74 ? 400 LYS A CD 1 ATOM 2978 C CE . LYS A 1 416 ? -41.161 0.012 -19.349 1.00 21.93 ? 400 LYS A CE 1 ATOM 2979 N NZ . LYS A 1 416 ? -40.491 -1.301 -19.500 1.00 26.00 ? 400 LYS A NZ 1 ATOM 2980 N N . MET A 1 417 ? -41.762 4.962 -14.454 1.00 14.47 ? 401 MET A N 1 ATOM 2981 C CA . MET A 1 417 ? -41.514 5.671 -13.205 1.00 16.74 ? 401 MET A CA 1 ATOM 2982 C C . MET A 1 417 ? -40.274 5.142 -12.500 1.00 15.32 ? 401 MET A C 1 ATOM 2983 O O . MET A 1 417 ? -40.160 3.945 -12.240 1.00 17.88 ? 401 MET A O 1 ATOM 2984 C CB . MET A 1 417 ? -42.719 5.525 -12.273 1.00 19.42 ? 401 MET A CB 1 ATOM 2985 C CG . MET A 1 417 ? -42.684 6.447 -11.065 1.00 23.72 ? 401 MET A CG 1 ATOM 2986 S SD . MET A 1 417 ? -43.083 8.153 -11.487 1.00 36.44 ? 401 MET A SD 1 ATOM 2987 C CE . MET A 1 417 ? -44.849 8.025 -11.772 1.00 19.50 ? 401 MET A CE 1 ATOM 2988 N N . PHE A 1 418 ? -39.344 6.040 -12.196 1.00 19.06 ? 402 PHE A N 1 ATOM 2989 C CA . PHE A 1 418 ? -38.207 5.696 -11.356 1.00 15.17 ? 402 PHE A CA 1 ATOM 2990 C C . PHE A 1 418 ? -38.671 5.604 -9.910 1.00 18.53 ? 402 PHE A C 1 ATOM 2991 O O . PHE A 1 418 ? -39.071 6.604 -9.314 1.00 19.66 ? 402 PHE A O 1 ATOM 2992 C CB . PHE A 1 418 ? -37.101 6.742 -11.488 1.00 19.76 ? 402 PHE A CB 1 ATOM 2993 C CG . PHE A 1 418 ? -36.026 6.619 -10.447 1.00 12.34 ? 402 PHE A CG 1 ATOM 2994 C CD1 . PHE A 1 418 ? -36.136 7.287 -9.240 1.00 10.46 ? 402 PHE A CD1 1 ATOM 2995 C CD2 . PHE A 1 418 ? -34.907 5.837 -10.674 1.00 7.94 ? 402 PHE A CD2 1 ATOM 2996 C CE1 . PHE A 1 418 ? -35.152 7.177 -8.278 1.00 9.47 ? 402 PHE A CE1 1 ATOM 2997 C CE2 . PHE A 1 418 ? -33.917 5.724 -9.715 1.00 4.95 ? 402 PHE A CE2 1 ATOM 2998 C CZ . PHE A 1 418 ? -34.041 6.395 -8.516 1.00 6.15 ? 402 PHE A CZ 1 ATOM 2999 N N . GLU A 1 419 ? -38.627 4.399 -9.355 1.00 25.00 ? 403 GLU A N 1 ATOM 3000 C CA . GLU A 1 419 ? -39.112 4.163 -8.002 1.00 26.62 ? 403 GLU A CA 1 ATOM 3001 C C . GLU A 1 419 ? -37.951 4.107 -7.013 1.00 24.74 ? 403 GLU A C 1 ATOM 3002 O O . GLU A 1 419 ? -36.959 3.415 -7.242 1.00 15.94 ? 403 GLU A O 1 ATOM 3003 C CB . GLU A 1 419 ? -39.907 2.858 -7.948 1.00 30.79 ? 403 GLU A CB 1 ATOM 3004 C CG . GLU A 1 419 ? -40.930 2.698 -9.072 1.00 28.41 ? 403 GLU A CG 1 ATOM 3005 C CD . GLU A 1 419 ? -42.225 3.440 -8.803 1.00 34.30 ? 403 GLU A CD 1 ATOM 3006 O OE1 . GLU A 1 419 ? -42.169 4.571 -8.278 1.00 32.74 ? 403 GLU A OE1 1 ATOM 3007 O OE2 . GLU A 1 419 ? -43.302 2.888 -9.119 1.00 48.99 ? 403 GLU A OE2 1 ATOM 3008 N N . ARG B 1 18 ? -22.883 0.185 53.663 1.00 14.78 ? 2 ARG B N 1 ATOM 3009 C CA . ARG B 1 18 ? -22.969 0.017 52.218 1.00 19.54 ? 2 ARG B CA 1 ATOM 3010 C C . ARG B 1 18 ? -23.842 -1.182 51.854 1.00 19.49 ? 2 ARG B C 1 ATOM 3011 O O . ARG B 1 18 ? -24.430 -1.231 50.773 1.00 17.46 ? 2 ARG B O 1 ATOM 3012 C CB . ARG B 1 18 ? -21.572 -0.161 51.618 1.00 26.88 ? 2 ARG B CB 1 ATOM 3013 C CG . ARG B 1 18 ? -20.904 -1.482 51.968 1.00 24.23 ? 2 ARG B CG 1 ATOM 3014 C CD . ARG B 1 18 ? -20.057 -1.987 50.814 1.00 34.13 ? 2 ARG B CD 1 ATOM 3015 N NE . ARG B 1 18 ? -19.526 -3.324 51.061 1.00 31.46 ? 2 ARG B NE 1 ATOM 3016 C CZ . ARG B 1 18 ? -18.807 -4.017 50.184 1.00 34.77 ? 2 ARG B CZ 1 ATOM 3017 N NH1 . ARG B 1 18 ? -18.526 -3.502 48.994 1.00 34.40 ? 2 ARG B NH1 1 ATOM 3018 N NH2 . ARG B 1 18 ? -18.366 -5.227 50.495 1.00 40.97 ? 2 ARG B NH2 1 ATOM 3019 N N . CYS B 1 19 ? -23.916 -2.150 52.762 1.00 20.28 ? 3 CYS B N 1 ATOM 3020 C CA . CYS B 1 19 ? -24.707 -3.353 52.538 1.00 12.55 ? 3 CYS B CA 1 ATOM 3021 C C . CYS B 1 19 ? -26.098 -3.196 53.134 1.00 12.03 ? 3 CYS B C 1 ATOM 3022 O O . CYS B 1 19 ? -26.289 -2.462 54.104 1.00 12.07 ? 3 CYS B O 1 ATOM 3023 C CB . CYS B 1 19 ? -24.016 -4.570 53.159 1.00 11.24 ? 3 CYS B CB 1 ATOM 3024 S SG . CYS B 1 19 ? -22.500 -5.079 52.329 1.00 9.90 ? 3 CYS B SG 1 ATOM 3025 N N . VAL B 1 20 ? -27.067 -3.890 52.548 1.00 11.88 ? 4 VAL B N 1 ATOM 3026 C CA . VAL B 1 20 ? -28.432 -3.871 53.052 1.00 8.34 ? 4 VAL B CA 1 ATOM 3027 C C . VAL B 1 20 ? -28.629 -5.002 54.051 1.00 11.35 ? 4 VAL B C 1 ATOM 3028 O O . VAL B 1 20 ? -28.335 -6.160 53.758 1.00 10.25 ? 4 VAL B O 1 ATOM 3029 C CB . VAL B 1 20 ? -29.452 -4.040 51.920 1.00 8.36 ? 4 VAL B CB 1 ATOM 3030 C CG1 . VAL B 1 20 ? -30.868 -3.937 52.469 1.00 10.51 ? 4 VAL B CG1 1 ATOM 3031 C CG2 . VAL B 1 20 ? -29.221 -2.999 50.842 1.00 11.35 ? 4 VAL B CG2 1 ATOM 3032 N N . GLY B 1 21 ? -29.134 -4.663 55.232 1.00 10.38 ? 5 GLY B N 1 ATOM 3033 C CA . GLY B 1 21 ? -29.356 -5.648 56.273 1.00 6.96 ? 5 GLY B CA 1 ATOM 3034 C C . GLY B 1 21 ? -30.621 -6.451 56.042 1.00 6.27 ? 5 GLY B C 1 ATOM 3035 O O . GLY B 1 21 ? -31.665 -5.897 55.698 1.00 8.02 ? 5 GLY B O 1 ATOM 3036 N N . ILE B 1 22 ? -30.526 -7.764 56.227 1.00 12.75 ? 6 ILE B N 1 ATOM 3037 C CA . ILE B 1 22 ? -31.677 -8.645 56.064 1.00 10.87 ? 6 ILE B CA 1 ATOM 3038 C C . ILE B 1 22 ? -32.685 -8.385 57.177 1.00 11.85 ? 6 ILE B C 1 ATOM 3039 O O . ILE B 1 22 ? -32.307 -8.162 58.325 1.00 13.78 ? 6 ILE B O 1 ATOM 3040 C CB . ILE B 1 22 ? -31.267 -10.131 56.104 1.00 14.22 ? 6 ILE B CB 1 ATOM 3041 C CG1 . ILE B 1 22 ? -30.209 -10.425 55.038 1.00 9.99 ? 6 ILE B CG1 1 ATOM 3042 C CG2 . ILE B 1 22 ? -32.486 -11.022 55.898 1.00 7.51 ? 6 ILE B CG2 1 ATOM 3043 C CD1 . ILE B 1 22 ? -29.629 -11.822 55.121 1.00 12.93 ? 6 ILE B CD1 1 ATOM 3044 N N . GLY B 1 23 ? -33.969 -8.415 56.833 1.00 10.47 ? 7 GLY B N 1 ATOM 3045 C CA . GLY B 1 23 ? -35.018 -8.162 57.802 1.00 7.25 ? 7 GLY B CA 1 ATOM 3046 C C . GLY B 1 23 ? -35.471 -9.419 58.517 1.00 8.74 ? 7 GLY B C 1 ATOM 3047 O O . GLY B 1 23 ? -35.105 -10.530 58.135 1.00 12.80 ? 7 GLY B O 1 ATOM 3048 N N . ASN B 1 24 ? -36.275 -9.238 59.560 1.00 12.42 ? 8 ASN B N 1 ATOM 3049 C CA . ASN B 1 24 ? -36.785 -10.358 60.341 1.00 9.10 ? 8 ASN B CA 1 ATOM 3050 C C . ASN B 1 24 ? -37.659 -11.289 59.507 1.00 6.89 ? 8 ASN B C 1 ATOM 3051 O O . ASN B 1 24 ? -37.716 -12.492 59.760 1.00 10.60 ? 8 ASN B O 1 ATOM 3052 C CB . ASN B 1 24 ? -37.582 -9.846 61.544 1.00 13.26 ? 8 ASN B CB 1 ATOM 3053 C CG . ASN B 1 24 ? -36.692 -9.379 62.680 1.00 21.13 ? 8 ASN B CG 1 ATOM 3054 O OD1 . ASN B 1 24 ? -35.741 -10.063 63.061 1.00 18.28 ? 8 ASN B OD1 1 ATOM 3055 N ND2 . ASN B 1 24 ? -36.999 -8.209 63.230 1.00 34.00 ? 8 ASN B ND2 1 ATOM 3056 N N . ARG B 1 25 ? -38.340 -10.726 58.515 1.00 7.76 ? 9 ARG B N 1 ATOM 3057 C CA . ARG B 1 25 ? -39.266 -11.493 57.687 1.00 3.75 ? 9 ARG B CA 1 ATOM 3058 C C . ARG B 1 25 ? -38.561 -12.347 56.636 1.00 6.24 ? 9 ARG B C 1 ATOM 3059 O O . ARG B 1 25 ? -39.194 -13.172 55.978 1.00 10.24 ? 9 ARG B O 1 ATOM 3060 C CB . ARG B 1 25 ? -40.264 -10.557 57.006 1.00 4.18 ? 9 ARG B CB 1 ATOM 3061 C CG . ARG B 1 25 ? -41.258 -9.919 57.964 1.00 8.52 ? 9 ARG B CG 1 ATOM 3062 C CD . ARG B 1 25 ? -42.319 -9.151 57.205 1.00 6.40 ? 9 ARG B CD 1 ATOM 3063 N NE . ARG B 1 25 ? -41.764 -7.964 56.562 1.00 7.23 ? 9 ARG B NE 1 ATOM 3064 C CZ . ARG B 1 25 ? -42.203 -7.447 55.418 1.00 9.04 ? 9 ARG B CZ 1 ATOM 3065 N NH1 . ARG B 1 25 ? -43.212 -8.004 54.761 1.00 15.29 ? 9 ARG B NH1 1 ATOM 3066 N NH2 . ARG B 1 25 ? -41.624 -6.364 54.919 1.00 8.05 ? 9 ARG B NH2 1 ATOM 3067 N N . ASP B 1 26 ? -37.255 -12.154 56.487 1.00 7.83 ? 10 ASP B N 1 ATOM 3068 C CA . ASP B 1 26 ? -36.489 -12.845 55.454 1.00 5.77 ? 10 ASP B CA 1 ATOM 3069 C C . ASP B 1 26 ? -35.671 -14.024 55.981 1.00 6.28 ? 10 ASP B C 1 ATOM 3070 O O . ASP B 1 26 ? -34.799 -14.534 55.281 1.00 2.52 ? 10 ASP B O 1 ATOM 3071 C CB . ASP B 1 26 ? -35.576 -11.849 54.739 1.00 7.55 ? 10 ASP B CB 1 ATOM 3072 C CG . ASP B 1 26 ? -36.254 -11.190 53.550 1.00 11.20 ? 10 ASP B CG 1 ATOM 3073 O OD1 . ASP B 1 26 ? -36.205 -11.790 52.458 1.00 22.10 ? 10 ASP B OD1 1 ATOM 3074 O OD2 . ASP B 1 26 ? -36.832 -10.092 53.693 1.00 11.93 ? 10 ASP B OD2 1 ATOM 3075 N N . PHE B 1 27 ? -35.950 -14.463 57.205 1.00 4.26 ? 11 PHE B N 1 ATOM 3076 C CA . PHE B 1 27 ? -35.306 -15.665 57.724 1.00 2.55 ? 11 PHE B CA 1 ATOM 3077 C C . PHE B 1 27 ? -36.138 -16.371 58.788 1.00 2.19 ? 11 PHE B C 1 ATOM 3078 O O . PHE B 1 27 ? -37.045 -15.788 59.379 1.00 2.87 ? 11 PHE B O 1 ATOM 3079 C CB . PHE B 1 27 ? -33.914 -15.342 58.273 1.00 4.44 ? 11 PHE B CB 1 ATOM 3080 C CG . PHE B 1 27 ? -33.926 -14.555 59.552 1.00 5.41 ? 11 PHE B CG 1 ATOM 3081 C CD1 . PHE B 1 27 ? -34.016 -15.198 60.776 1.00 5.67 ? 11 PHE B CD1 1 ATOM 3082 C CD2 . PHE B 1 27 ? -33.830 -13.174 59.534 1.00 5.90 ? 11 PHE B CD2 1 ATOM 3083 C CE1 . PHE B 1 27 ? -34.020 -14.479 61.954 1.00 4.79 ? 11 PHE B CE1 1 ATOM 3084 C CE2 . PHE B 1 27 ? -33.833 -12.449 60.709 1.00 6.70 ? 11 PHE B CE2 1 ATOM 3085 C CZ . PHE B 1 27 ? -33.928 -13.103 61.921 1.00 4.06 ? 11 PHE B CZ 1 ATOM 3086 N N . VAL B 1 28 ? -35.811 -17.638 59.019 1.00 1.98 ? 12 VAL B N 1 ATOM 3087 C CA . VAL B 1 28 ? -36.515 -18.461 59.992 1.00 2.73 ? 12 VAL B CA 1 ATOM 3088 C C . VAL B 1 28 ? -35.531 -19.328 60.763 1.00 3.54 ? 12 VAL B C 1 ATOM 3089 O O . VAL B 1 28 ? -34.775 -20.094 60.168 1.00 5.87 ? 12 VAL B O 1 ATOM 3090 C CB . VAL B 1 28 ? -37.544 -19.383 59.300 1.00 3.29 ? 12 VAL B CB 1 ATOM 3091 C CG1 . VAL B 1 28 ? -37.739 -20.672 60.087 1.00 7.12 ? 12 VAL B CG1 1 ATOM 3092 C CG2 . VAL B 1 28 ? -38.870 -18.663 59.121 1.00 2.25 ? 12 VAL B CG2 1 ATOM 3093 N N . GLU B 1 29 ? -35.534 -19.197 62.085 1.00 2.97 ? 13 GLU B N 1 ATOM 3094 C CA . GLU B 1 29 ? -34.770 -20.099 62.934 1.00 4.29 ? 13 GLU B CA 1 ATOM 3095 C C . GLU B 1 29 ? -35.712 -21.152 63.495 1.00 8.11 ? 13 GLU B C 1 ATOM 3096 O O . GLU B 1 29 ? -36.707 -20.823 64.141 1.00 8.32 ? 13 GLU B O 1 ATOM 3097 C CB . GLU B 1 29 ? -34.098 -19.347 64.083 1.00 4.46 ? 13 GLU B CB 1 ATOM 3098 C CG . GLU B 1 29 ? -33.236 -20.246 64.959 1.00 4.95 ? 13 GLU B CG 1 ATOM 3099 C CD . GLU B 1 29 ? -32.871 -19.609 66.285 1.00 5.60 ? 13 GLU B CD 1 ATOM 3100 O OE1 . GLU B 1 29 ? -32.285 -20.309 67.139 1.00 3.07 ? 13 GLU B OE1 1 ATOM 3101 O OE2 . GLU B 1 29 ? -33.170 -18.412 66.475 1.00 8.59 ? 13 GLU B OE2 1 ATOM 3102 N N . GLY B 1 30 ? -35.403 -22.419 63.244 1.00 4.54 ? 14 GLY B N 1 ATOM 3103 C CA . GLY B 1 30 ? -36.240 -23.502 63.718 1.00 6.95 ? 14 GLY B CA 1 ATOM 3104 C C . GLY B 1 30 ? -35.944 -23.847 65.162 1.00 8.53 ? 14 GLY B C 1 ATOM 3105 O O . GLY B 1 30 ? -34.797 -23.778 65.601 1.00 10.96 ? 14 GLY B O 1 ATOM 3106 N N . LEU B 1 31 ? -36.984 -24.199 65.909 1.00 10.05 ? 15 LEU B N 1 ATOM 3107 C CA A LEU B 1 31 ? -36.821 -24.670 67.277 0.09 13.24 ? 15 LEU B CA 1 ATOM 3108 C CA B LEU B 1 31 ? -36.810 -24.659 67.279 0.91 12.95 ? 15 LEU B CA 1 ATOM 3109 C C . LEU B 1 31 ? -35.767 -25.769 67.285 1.00 14.41 ? 15 LEU B C 1 ATOM 3110 O O . LEU B 1 31 ? -35.004 -25.918 68.242 1.00 11.11 ? 15 LEU B O 1 ATOM 3111 C CB A LEU B 1 31 ? -38.156 -25.198 67.806 0.09 19.79 ? 15 LEU B CB 1 ATOM 3112 C CB B LEU B 1 31 ? -38.137 -25.169 67.840 0.91 19.60 ? 15 LEU B CB 1 ATOM 3113 C CG A LEU B 1 31 ? -38.223 -25.682 69.255 0.09 13.32 ? 15 LEU B CG 1 ATOM 3114 C CG B LEU B 1 31 ? -38.110 -25.716 69.267 0.91 13.22 ? 15 LEU B CG 1 ATOM 3115 C CD1 A LEU B 1 31 ? -39.651 -25.579 69.759 0.09 13.49 ? 15 LEU B CD1 1 ATOM 3116 C CD1 B LEU B 1 31 ? -37.711 -24.635 70.260 0.91 13.59 ? 15 LEU B CD1 1 ATOM 3117 C CD2 A LEU B 1 31 ? -37.731 -27.115 69.396 0.09 12.42 ? 15 LEU B CD2 1 ATOM 3118 C CD2 B LEU B 1 31 ? -39.467 -26.305 69.624 0.91 12.76 ? 15 LEU B CD2 1 ATOM 3119 N N . SER B 1 32 ? -35.740 -26.532 66.198 1.00 7.79 ? 16 SER B N 1 ATOM 3120 C CA . SER B 1 32 ? -34.744 -27.569 65.974 1.00 6.27 ? 16 SER B CA 1 ATOM 3121 C C . SER B 1 32 ? -34.476 -27.616 64.474 1.00 6.69 ? 16 SER B C 1 ATOM 3122 O O . SER B 1 32 ? -35.401 -27.474 63.673 1.00 7.78 ? 16 SER B O 1 ATOM 3123 C CB . SER B 1 32 ? -35.250 -28.927 66.457 1.00 3.83 ? 16 SER B CB 1 ATOM 3124 O OG . SER B 1 32 ? -36.322 -29.383 65.654 1.00 7.18 ? 16 SER B OG 1 ATOM 3125 N N . GLY B 1 33 ? -33.217 -27.800 64.090 1.00 9.18 ? 17 GLY B N 1 ATOM 3126 C CA . GLY B 1 33 ? -32.863 -27.860 62.684 1.00 5.34 ? 17 GLY B CA 1 ATOM 3127 C C . GLY B 1 33 ? -31.925 -26.750 62.254 1.00 3.32 ? 17 GLY B C 1 ATOM 3128 O O . GLY B 1 33 ? -30.793 -26.666 62.728 1.00 6.45 ? 17 GLY B O 1 ATOM 3129 N N . ALA B 1 34 ? -32.403 -25.892 61.357 1.00 3.76 ? 18 ALA B N 1 ATOM 3130 C CA . ALA B 1 34 ? -31.546 -24.909 60.707 1.00 3.77 ? 18 ALA B CA 1 ATOM 3131 C C . ALA B 1 34 ? -32.101 -23.493 60.777 1.00 3.72 ? 18 ALA B C 1 ATOM 3132 O O . ALA B 1 34 ? -33.222 -23.268 61.236 1.00 3.12 ? 18 ALA B O 1 ATOM 3133 C CB . ALA B 1 34 ? -31.357 -25.299 59.261 1.00 5.72 ? 18 ALA B CB 1 ATOM 3134 N N . THR B 1 35 ? -31.293 -22.543 60.318 1.00 5.31 ? 19 THR B N 1 ATOM 3135 C CA . THR B 1 35 ? -31.767 -21.200 60.028 1.00 6.31 ? 19 THR B CA 1 ATOM 3136 C C . THR B 1 35 ? -31.803 -21.028 58.515 1.00 3.35 ? 19 THR B C 1 ATOM 3137 O O . THR B 1 35 ? -30.766 -21.085 57.854 1.00 3.01 ? 19 THR B O 1 ATOM 3138 C CB . THR B 1 35 ? -30.845 -20.108 60.605 1.00 6.62 ? 19 THR B CB 1 ATOM 3139 O OG1 . THR B 1 35 ? -30.824 -20.174 62.035 1.00 13.54 ? 19 THR B OG1 1 ATOM 3140 C CG2 . THR B 1 35 ? -31.336 -18.736 60.192 1.00 5.51 ? 19 THR B CG2 1 ATOM 3141 N N . TRP B 1 36 ? -32.996 -20.821 57.968 1.00 3.66 ? 20 TRP B N 1 ATOM 3142 C CA . TRP B 1 36 ? -33.147 -20.588 56.537 1.00 2.38 ? 20 TRP B CA 1 ATOM 3143 C C . TRP B 1 36 ? -33.322 -19.098 56.281 1.00 2.68 ? 20 TRP B C 1 ATOM 3144 O O . TRP B 1 36 ? -34.053 -18.420 57.001 1.00 2.09 ? 20 TRP B O 1 ATOM 3145 C CB . TRP B 1 36 ? -34.339 -21.373 55.987 1.00 2.97 ? 20 TRP B CB 1 ATOM 3146 C CG . TRP B 1 36 ? -34.090 -22.851 55.899 1.00 2.17 ? 20 TRP B CG 1 ATOM 3147 C CD1 . TRP B 1 36 ? -32.898 -23.493 56.071 1.00 1.94 ? 20 TRP B CD1 1 ATOM 3148 C CD2 . TRP B 1 36 ? -35.058 -23.869 55.621 1.00 2.51 ? 20 TRP B CD2 1 ATOM 3149 N NE1 . TRP B 1 36 ? -33.064 -24.847 55.914 1.00 1.27 ? 20 TRP B NE1 1 ATOM 3150 C CE2 . TRP B 1 36 ? -34.380 -25.104 55.638 1.00 2.95 ? 20 TRP B CE2 1 ATOM 3151 C CE3 . TRP B 1 36 ? -36.431 -23.856 55.357 1.00 1.92 ? 20 TRP B CE3 1 ATOM 3152 C CZ2 . TRP B 1 36 ? -35.030 -26.314 55.401 1.00 3.67 ? 20 TRP B CZ2 1 ATOM 3153 C CZ3 . TRP B 1 36 ? -37.073 -25.058 55.122 1.00 1.74 ? 20 TRP B CZ3 1 ATOM 3154 C CH2 . TRP B 1 36 ? -36.372 -26.270 55.148 1.00 1.66 ? 20 TRP B CH2 1 ATOM 3155 N N . VAL B 1 37 ? -32.641 -18.592 55.258 1.00 5.00 ? 21 VAL B N 1 ATOM 3156 C CA . VAL B 1 37 ? -32.635 -17.161 54.981 1.00 4.44 ? 21 VAL B CA 1 ATOM 3157 C C . VAL B 1 37 ? -32.900 -16.880 53.506 1.00 3.68 ? 21 VAL B C 1 ATOM 3158 O O . VAL B 1 37 ? -32.434 -17.606 52.629 1.00 3.01 ? 21 VAL B O 1 ATOM 3159 C CB . VAL B 1 37 ? -31.282 -16.531 55.368 1.00 3.40 ? 21 VAL B CB 1 ATOM 3160 C CG1 . VAL B 1 37 ? -31.362 -15.013 55.326 1.00 1.80 ? 21 VAL B CG1 1 ATOM 3161 C CG2 . VAL B 1 37 ? -30.838 -17.018 56.745 1.00 3.15 ? 21 VAL B CG2 1 ATOM 3162 N N . ASP B 1 38 ? -33.656 -15.819 53.244 1.00 6.17 ? 22 ASP B N 1 ATOM 3163 C CA . ASP B 1 38 ? -33.954 -15.395 51.883 1.00 6.10 ? 22 ASP B CA 1 ATOM 3164 C C . ASP B 1 38 ? -33.236 -14.094 51.554 1.00 6.65 ? 22 ASP B C 1 ATOM 3165 O O . ASP B 1 38 ? -33.444 -13.076 52.214 1.00 9.42 ? 22 ASP B O 1 ATOM 3166 C CB . ASP B 1 38 ? -35.460 -15.206 51.705 1.00 7.30 ? 22 ASP B CB 1 ATOM 3167 C CG . ASP B 1 38 ? -36.216 -16.516 51.726 1.00 9.89 ? 22 ASP B CG 1 ATOM 3168 O OD1 . ASP B 1 38 ? -35.586 -17.570 51.494 1.00 5.33 ? 22 ASP B OD1 1 ATOM 3169 O OD2 . ASP B 1 38 ? -37.440 -16.493 51.972 1.00 8.76 ? 22 ASP B OD2 1 ATOM 3170 N N . VAL B 1 39 ? -32.388 -14.134 50.533 1.00 8.29 ? 23 VAL B N 1 ATOM 3171 C CA . VAL B 1 39 ? -31.705 -12.935 50.069 1.00 6.85 ? 23 VAL B CA 1 ATOM 3172 C C . VAL B 1 39 ? -31.814 -12.807 48.557 1.00 6.89 ? 23 VAL B C 1 ATOM 3173 O O . VAL B 1 39 ? -31.881 -13.806 47.841 1.00 6.12 ? 23 VAL B O 1 ATOM 3174 C CB . VAL B 1 39 ? -30.214 -12.941 50.458 1.00 8.60 ? 23 VAL B CB 1 ATOM 3175 C CG1 . VAL B 1 39 ? -30.052 -13.086 51.967 1.00 6.89 ? 23 VAL B CG1 1 ATOM 3176 C CG2 . VAL B 1 39 ? -29.472 -14.048 49.727 1.00 6.56 ? 23 VAL B CG2 1 ATOM 3177 N N . VAL B 1 40 ? -31.840 -11.568 48.080 1.00 8.69 ? 24 VAL B N 1 ATOM 3178 C CA . VAL B 1 40 ? -31.830 -11.298 46.649 1.00 10.11 ? 24 VAL B CA 1 ATOM 3179 C C . VAL B 1 40 ? -30.574 -10.509 46.299 1.00 4.99 ? 24 VAL B C 1 ATOM 3180 O O . VAL B 1 40 ? -30.322 -9.447 46.869 1.00 9.65 ? 24 VAL B O 1 ATOM 3181 C CB . VAL B 1 40 ? -33.076 -10.508 46.211 1.00 9.15 ? 24 VAL B CB 1 ATOM 3182 C CG1 . VAL B 1 40 ? -33.025 -10.235 44.719 1.00 6.31 ? 24 VAL B CG1 1 ATOM 3183 C CG2 . VAL B 1 40 ? -34.342 -11.274 46.570 1.00 6.87 ? 24 VAL B CG2 1 ATOM 3184 N N . LEU B 1 41 ? -29.789 -11.031 45.363 1.00 8.17 ? 25 LEU B N 1 ATOM 3185 C CA . LEU B 1 41 ? -28.510 -10.426 45.016 1.00 10.31 ? 25 LEU B CA 1 ATOM 3186 C C . LEU B 1 41 ? -28.599 -9.665 43.698 1.00 6.53 ? 25 LEU B C 1 ATOM 3187 O O . LEU B 1 41 ? -28.998 -10.221 42.675 1.00 7.06 ? 25 LEU B O 1 ATOM 3188 C CB . LEU B 1 41 ? -27.425 -11.501 44.929 1.00 5.90 ? 25 LEU B CB 1 ATOM 3189 C CG . LEU B 1 41 ? -27.300 -12.397 46.162 1.00 3.55 ? 25 LEU B CG 1 ATOM 3190 C CD1 . LEU B 1 41 ? -26.187 -13.408 45.965 1.00 5.26 ? 25 LEU B CD1 1 ATOM 3191 C CD2 . LEU B 1 41 ? -27.058 -11.566 47.412 1.00 4.97 ? 25 LEU B CD2 1 ATOM 3192 N N . GLU B 1 42 ? -28.223 -8.390 43.730 1.00 16.86 ? 26 GLU B N 1 ATOM 3193 C CA . GLU B 1 42 ? -28.246 -7.561 42.532 1.00 14.22 ? 26 GLU B CA 1 ATOM 3194 C C . GLU B 1 42 ? -26.903 -6.876 42.318 1.00 13.73 ? 26 GLU B C 1 ATOM 3195 O O . GLU B 1 42 ? -26.264 -6.412 43.263 1.00 11.47 ? 26 GLU B O 1 ATOM 3196 C CB . GLU B 1 42 ? -29.358 -6.510 42.619 1.00 15.61 ? 26 GLU B CB 1 ATOM 3197 C CG . GLU B 1 42 ? -30.654 -7.023 43.240 1.00 18.83 ? 26 GLU B CG 1 ATOM 3198 C CD . GLU B 1 42 ? -31.899 -6.630 42.460 1.00 28.03 ? 26 GLU B CD 1 ATOM 3199 O OE1 . GLU B 1 42 ? -31.783 -6.297 41.261 1.00 27.77 ? 26 GLU B OE1 1 ATOM 3200 O OE2 . GLU B 1 42 ? -32.999 -6.661 43.051 1.00 22.66 ? 26 GLU B OE2 1 ATOM 3201 N N . HIS B 1 43 ? -26.481 -6.835 41.060 1.00 16.22 ? 27 HIS B N 1 ATOM 3202 C CA . HIS B 1 43 ? -25.278 -6.123 40.651 1.00 18.89 ? 27 HIS B CA 1 ATOM 3203 C C . HIS B 1 43 ? -25.148 -4.769 41.342 1.00 21.08 ? 27 HIS B C 1 ATOM 3204 O O . HIS B 1 43 ? -26.064 -3.948 41.297 1.00 17.94 ? 27 HIS B O 1 ATOM 3205 C CB . HIS B 1 43 ? -25.314 -5.910 39.140 1.00 25.19 ? 27 HIS B CB 1 ATOM 3206 C CG . HIS B 1 43 ? -26.638 -5.424 38.639 1.00 25.57 ? 27 HIS B CG 1 ATOM 3207 N ND1 . HIS B 1 43 ? -27.006 -4.094 38.673 1.00 31.18 ? 27 HIS B ND1 1 ATOM 3208 C CD2 . HIS B 1 43 ? -27.691 -6.090 38.112 1.00 22.75 ? 27 HIS B CD2 1 ATOM 3209 C CE1 . HIS B 1 43 ? -28.222 -3.964 38.177 1.00 24.90 ? 27 HIS B CE1 1 ATOM 3210 N NE2 . HIS B 1 43 ? -28.662 -5.161 37.827 1.00 24.97 ? 27 HIS B NE2 1 ATOM 3211 N N . GLY B 1 44 ? -24.006 -4.544 41.984 1.00 25.90 ? 28 GLY B N 1 ATOM 3212 C CA . GLY B 1 44 ? -23.693 -3.251 42.568 1.00 17.77 ? 28 GLY B CA 1 ATOM 3213 C C . GLY B 1 44 ? -24.234 -3.061 43.972 1.00 21.55 ? 28 GLY B C 1 ATOM 3214 O O . GLY B 1 44 ? -24.066 -1.997 44.568 1.00 20.45 ? 28 GLY B O 1 ATOM 3215 N N . SER B 1 45 ? -24.888 -4.089 44.503 1.00 18.87 ? 29 SER B N 1 ATOM 3216 C CA . SER B 1 45 ? -25.427 -4.031 45.855 1.00 11.73 ? 29 SER B CA 1 ATOM 3217 C C . SER B 1 45 ? -25.124 -5.319 46.609 1.00 14.54 ? 29 SER B C 1 ATOM 3218 O O . SER B 1 45 ? -25.066 -6.395 46.016 1.00 12.63 ? 29 SER B O 1 ATOM 3219 C CB . SER B 1 45 ? -26.936 -3.794 45.816 1.00 16.43 ? 29 SER B CB 1 ATOM 3220 O OG . SER B 1 45 ? -27.503 -3.925 47.108 1.00 27.78 ? 29 SER B OG 1 ATOM 3221 N N . CYS B 1 46 ? -24.926 -5.201 47.917 1.00 13.04 ? 30 CYS B N 1 ATOM 3222 C CA . CYS B 1 46 ? -24.641 -6.362 48.750 1.00 10.93 ? 30 CYS B CA 1 ATOM 3223 C C . CYS B 1 46 ? -25.615 -6.447 49.915 1.00 10.21 ? 30 CYS B C 1 ATOM 3224 O O . CYS B 1 46 ? -26.217 -5.449 50.312 1.00 12.74 ? 30 CYS B O 1 ATOM 3225 C CB . CYS B 1 46 ? -23.206 -6.304 49.275 1.00 10.10 ? 30 CYS B CB 1 ATOM 3226 S SG . CYS B 1 46 ? -22.857 -4.890 50.339 1.00 18.87 ? 30 CYS B SG 1 ATOM 3227 N N . VAL B 1 47 ? -25.764 -7.648 50.462 1.00 10.56 ? 31 VAL B N 1 ATOM 3228 C CA . VAL B 1 47 ? -26.634 -7.859 51.609 1.00 17.41 ? 31 VAL B CA 1 ATOM 3229 C C . VAL B 1 47 ? -25.802 -8.346 52.785 1.00 8.73 ? 31 VAL B C 1 ATOM 3230 O O . VAL B 1 47 ? -24.755 -8.964 52.598 1.00 9.88 ? 31 VAL B O 1 ATOM 3231 C CB . VAL B 1 47 ? -27.746 -8.880 51.302 1.00 10.74 ? 31 VAL B CB 1 ATOM 3232 C CG1 . VAL B 1 47 ? -28.596 -8.399 50.134 1.00 9.23 ? 31 VAL B CG1 1 ATOM 3233 C CG2 . VAL B 1 47 ? -27.154 -10.246 51.006 1.00 10.66 ? 31 VAL B CG2 1 ATOM 3234 N N . THR B 1 48 ? -26.259 -8.056 53.997 1.00 7.19 ? 32 THR B N 1 ATOM 3235 C CA . THR B 1 48 ? -25.497 -8.415 55.184 1.00 9.06 ? 32 THR B CA 1 ATOM 3236 C C . THR B 1 48 ? -26.378 -8.815 56.362 1.00 7.85 ? 32 THR B C 1 ATOM 3237 O O . THR B 1 48 ? -27.569 -8.509 56.400 1.00 11.50 ? 32 THR B O 1 ATOM 3238 C CB . THR B 1 48 ? -24.589 -7.255 55.626 1.00 9.81 ? 32 THR B CB 1 ATOM 3239 O OG1 . THR B 1 48 ? -23.824 -7.651 56.770 1.00 12.93 ? 32 THR B OG1 1 ATOM 3240 C CG2 . THR B 1 48 ? -25.415 -6.030 55.973 1.00 8.90 ? 32 THR B CG2 1 ATOM 3241 N N . THR B 1 49 ? -25.772 -9.513 57.316 1.00 13.03 ? 33 THR B N 1 ATOM 3242 C CA . THR B 1 49 ? -26.443 -9.892 58.551 1.00 10.93 ? 33 THR B CA 1 ATOM 3243 C C . THR B 1 49 ? -25.397 -10.264 59.592 1.00 13.38 ? 33 THR B C 1 ATOM 3244 O O . THR B 1 49 ? -24.202 -10.282 59.301 1.00 13.24 ? 33 THR B O 1 ATOM 3245 C CB . THR B 1 49 ? -27.382 -11.092 58.341 1.00 10.23 ? 33 THR B CB 1 ATOM 3246 O OG1 . THR B 1 49 ? -28.233 -11.244 59.484 1.00 11.70 ? 33 THR B OG1 1 ATOM 3247 C CG2 . THR B 1 49 ? -26.585 -12.375 58.127 1.00 11.83 ? 33 THR B CG2 1 ATOM 3248 N N . MET B 1 50 ? -25.846 -10.564 60.806 1.00 16.75 ? 34 MET B N 1 ATOM 3249 C CA . MET B 1 50 ? -24.941 -11.026 61.850 1.00 11.74 ? 34 MET B CA 1 ATOM 3250 C C . MET B 1 50 ? -25.708 -11.787 62.920 1.00 13.77 ? 34 MET B C 1 ATOM 3251 O O . MET B 1 50 ? -26.869 -11.487 63.200 1.00 11.88 ? 34 MET B O 1 ATOM 3252 C CB . MET B 1 50 ? -24.190 -9.850 62.478 1.00 18.99 ? 34 MET B CB 1 ATOM 3253 C CG . MET B 1 50 ? -25.009 -9.038 63.467 1.00 23.66 ? 34 MET B CG 1 ATOM 3254 S SD . MET B 1 50 ? -24.114 -7.597 64.084 1.00 32.64 ? 34 MET B SD 1 ATOM 3255 C CE . MET B 1 50 ? -22.633 -8.364 64.740 1.00 11.20 ? 34 MET B CE 1 ATOM 3256 N N . ALA B 1 51 ? -25.051 -12.775 63.518 1.00 22.55 ? 35 ALA B N 1 ATOM 3257 C CA . ALA B 1 51 ? -25.681 -13.596 64.541 1.00 19.59 ? 35 ALA B CA 1 ATOM 3258 C C . ALA B 1 51 ? -25.276 -13.128 65.933 1.00 22.47 ? 35 ALA B C 1 ATOM 3259 O O . ALA B 1 51 ? -24.298 -12.398 66.095 1.00 26.61 ? 35 ALA B O 1 ATOM 3260 C CB . ALA B 1 51 ? -25.316 -15.057 64.342 1.00 15.77 ? 35 ALA B CB 1 ATOM 3261 N N . LYS B 1 52 ? -26.045 -13.552 66.930 1.00 32.39 ? 36 LYS B N 1 ATOM 3262 C CA . LYS B 1 52 ? -25.795 -13.189 68.319 1.00 34.88 ? 36 LYS B CA 1 ATOM 3263 C C . LYS B 1 52 ? -24.309 -13.295 68.660 1.00 31.94 ? 36 LYS B C 1 ATOM 3264 O O . LYS B 1 52 ? -23.763 -14.393 68.764 1.00 32.89 ? 36 LYS B O 1 ATOM 3265 C CB . LYS B 1 52 ? -26.613 -14.095 69.243 1.00 35.63 ? 36 LYS B CB 1 ATOM 3266 C CG . LYS B 1 52 ? -26.945 -13.483 70.591 1.00 37.01 ? 36 LYS B CG 1 ATOM 3267 C CD . LYS B 1 52 ? -28.025 -14.285 71.298 1.00 29.37 ? 36 LYS B CD 1 ATOM 3268 C CE . LYS B 1 52 ? -28.365 -13.693 72.654 1.00 43.64 ? 36 LYS B CE 1 ATOM 3269 N NZ . LYS B 1 52 ? -29.593 -14.304 73.236 1.00 45.94 ? 36 LYS B NZ 1 ATOM 3270 N N . ASP B 1 53 ? -23.662 -12.144 68.826 1.00 29.63 ? 37 ASP B N 1 ATOM 3271 C CA . ASP B 1 53 ? -22.242 -12.092 69.172 1.00 27.41 ? 37 ASP B CA 1 ATOM 3272 C C . ASP B 1 53 ? -21.383 -12.894 68.197 1.00 27.85 ? 37 ASP B C 1 ATOM 3273 O O . ASP B 1 53 ? -20.640 -13.790 68.599 1.00 37.04 ? 37 ASP B O 1 ATOM 3274 C CB . ASP B 1 53 ? -22.020 -12.591 70.603 1.00 33.65 ? 37 ASP B CB 1 ATOM 3275 C CG . ASP B 1 53 ? -22.455 -11.581 71.647 1.00 40.05 ? 37 ASP B CG 1 ATOM 3276 O OD1 . ASP B 1 53 ? -22.215 -10.371 71.446 1.00 41.70 ? 37 ASP B OD1 1 ATOM 3277 O OD2 . ASP B 1 53 ? -23.038 -11.997 72.670 1.00 35.32 ? 37 ASP B OD2 1 ATOM 3278 N N . LYS B 1 54 ? -21.497 -12.567 66.913 1.00 29.89 ? 38 LYS B N 1 ATOM 3279 C CA . LYS B 1 54 ? -20.656 -13.162 65.880 1.00 24.84 ? 38 LYS B CA 1 ATOM 3280 C C . LYS B 1 54 ? -20.312 -12.116 64.824 1.00 21.93 ? 38 LYS B C 1 ATOM 3281 O O . LYS B 1 54 ? -20.914 -11.043 64.792 1.00 24.74 ? 38 LYS B O 1 ATOM 3282 C CB . LYS B 1 54 ? -21.364 -14.349 65.227 1.00 24.95 ? 38 LYS B CB 1 ATOM 3283 C CG . LYS B 1 54 ? -21.159 -15.670 65.951 1.00 28.66 ? 38 LYS B CG 1 ATOM 3284 C CD . LYS B 1 54 ? -21.849 -16.818 65.227 1.00 24.58 ? 38 LYS B CD 1 ATOM 3285 C CE . LYS B 1 54 ? -21.738 -18.123 66.001 1.00 28.46 ? 38 LYS B CE 1 ATOM 3286 N NZ . LYS B 1 54 ? -20.330 -18.573 66.184 1.00 34.94 ? 38 LYS B NZ 1 ATOM 3287 N N . PRO B 1 55 ? -19.336 -12.426 63.956 1.00 17.35 ? 39 PRO B N 1 ATOM 3288 C CA . PRO B 1 55 ? -18.915 -11.487 62.909 1.00 17.79 ? 39 PRO B CA 1 ATOM 3289 C C . PRO B 1 55 ? -20.024 -11.186 61.904 1.00 15.89 ? 39 PRO B C 1 ATOM 3290 O O . PRO B 1 55 ? -21.001 -11.931 61.819 1.00 13.62 ? 39 PRO B O 1 ATOM 3291 C CB . PRO B 1 55 ? -17.760 -12.223 62.217 1.00 14.66 ? 39 PRO B CB 1 ATOM 3292 C CG . PRO B 1 55 ? -17.300 -13.246 63.200 1.00 20.29 ? 39 PRO B CG 1 ATOM 3293 C CD . PRO B 1 55 ? -18.524 -13.655 63.950 1.00 22.74 ? 39 PRO B CD 1 ATOM 3294 N N . THR B 1 56 ? -19.864 -10.103 61.151 1.00 12.62 ? 40 THR B N 1 ATOM 3295 C CA . THR B 1 56 ? -20.830 -9.731 60.127 1.00 11.30 ? 40 THR B CA 1 ATOM 3296 C C . THR B 1 56 ? -20.584 -10.540 58.855 1.00 10.67 ? 40 THR B C 1 ATOM 3297 O O . THR B 1 56 ? -19.438 -10.777 58.472 1.00 15.00 ? 40 THR B O 1 ATOM 3298 C CB . THR B 1 56 ? -20.745 -8.230 59.800 1.00 11.54 ? 40 THR B CB 1 ATOM 3299 O OG1 . THR B 1 56 ? -20.947 -7.463 60.993 1.00 18.09 ? 40 THR B OG1 1 ATOM 3300 C CG2 . THR B 1 56 ? -21.797 -7.847 58.778 1.00 14.86 ? 40 THR B CG2 1 ATOM 3301 N N . LEU B 1 57 ? -21.666 -10.960 58.207 1.00 11.80 ? 41 LEU B N 1 ATOM 3302 C CA . LEU B 1 57 ? -21.583 -11.796 57.014 1.00 7.37 ? 41 LEU B CA 1 ATOM 3303 C C . LEU B 1 57 ? -22.156 -11.055 55.810 1.00 11.79 ? 41 LEU B C 1 ATOM 3304 O O . LEU B 1 57 ? -23.290 -10.582 55.854 1.00 11.31 ? 41 LEU B O 1 ATOM 3305 C CB . LEU B 1 57 ? -22.356 -13.097 57.242 1.00 5.54 ? 41 LEU B CB 1 ATOM 3306 C CG . LEU B 1 57 ? -22.296 -14.158 56.144 1.00 7.38 ? 41 LEU B CG 1 ATOM 3307 C CD1 . LEU B 1 57 ? -20.878 -14.658 55.954 1.00 9.85 ? 41 LEU B CD1 1 ATOM 3308 C CD2 . LEU B 1 57 ? -23.215 -15.316 56.487 1.00 11.99 ? 41 LEU B CD2 1 ATOM 3309 N N . ASP B 1 58 ? -21.371 -10.956 54.741 1.00 7.88 ? 42 ASP B N 1 ATOM 3310 C CA . ASP B 1 58 ? -21.797 -10.244 53.539 1.00 6.07 ? 42 ASP B CA 1 ATOM 3311 C C . ASP B 1 58 ? -21.866 -11.164 52.327 1.00 7.18 ? 42 ASP B C 1 ATOM 3312 O O . ASP B 1 58 ? -20.959 -11.959 52.088 1.00 10.01 ? 42 ASP B O 1 ATOM 3313 C CB . ASP B 1 58 ? -20.845 -9.086 53.242 1.00 8.85 ? 42 ASP B CB 1 ATOM 3314 C CG . ASP B 1 58 ? -20.881 -8.016 54.313 1.00 13.41 ? 42 ASP B CG 1 ATOM 3315 O OD1 . ASP B 1 58 ? -21.768 -8.081 55.189 1.00 13.62 ? 42 ASP B OD1 1 ATOM 3316 O OD2 . ASP B 1 58 ? -20.029 -7.102 54.272 1.00 14.82 ? 42 ASP B OD2 1 ATOM 3317 N N . ILE B 1 59 ? -22.951 -11.046 51.566 1.00 9.86 ? 43 ILE B N 1 ATOM 3318 C CA . ILE B 1 59 ? -23.120 -11.797 50.329 1.00 9.95 ? 43 ILE B CA 1 ATOM 3319 C C . ILE B 1 59 ? -23.306 -10.809 49.183 1.00 9.77 ? 43 ILE B C 1 ATOM 3320 O O . ILE B 1 59 ? -24.153 -9.919 49.260 1.00 9.79 ? 43 ILE B O 1 ATOM 3321 C CB . ILE B 1 59 ? -24.353 -12.716 50.385 1.00 7.11 ? 43 ILE B CB 1 ATOM 3322 C CG1 . ILE B 1 59 ? -24.603 -13.211 51.815 1.00 12.50 ? 43 ILE B CG1 1 ATOM 3323 C CG2 . ILE B 1 59 ? -24.186 -13.884 49.425 1.00 10.44 ? 43 ILE B CG2 1 ATOM 3324 C CD1 . ILE B 1 59 ? -23.517 -14.111 52.364 1.00 15.41 ? 43 ILE B CD1 1 ATOM 3325 N N . GLU B 1 60 ? -22.520 -10.959 48.122 1.00 10.56 ? 44 GLU B N 1 ATOM 3326 C CA . GLU B 1 60 ? -22.552 -10.000 47.023 1.00 7.02 ? 44 GLU B CA 1 ATOM 3327 C C . GLU B 1 60 ? -22.340 -10.662 45.666 1.00 8.46 ? 44 GLU B C 1 ATOM 3328 O O . GLU B 1 60 ? -21.360 -11.377 45.457 1.00 10.55 ? 44 GLU B O 1 ATOM 3329 C CB . GLU B 1 60 ? -21.491 -8.920 47.247 1.00 9.76 ? 44 GLU B CB 1 ATOM 3330 C CG . GLU B 1 60 ? -21.549 -7.767 46.257 1.00 10.36 ? 44 GLU B CG 1 ATOM 3331 C CD . GLU B 1 60 ? -20.654 -6.610 46.659 1.00 15.58 ? 44 GLU B CD 1 ATOM 3332 O OE1 . GLU B 1 60 ? -20.032 -6.684 47.740 1.00 23.91 ? 44 GLU B OE1 1 ATOM 3333 O OE2 . GLU B 1 60 ? -20.569 -5.628 45.892 1.00 17.42 ? 44 GLU B OE2 1 ATOM 3334 N N . LEU B 1 61 ? -23.268 -10.419 44.745 1.00 12.37 ? 45 LEU B N 1 ATOM 3335 C CA . LEU B 1 61 ? -23.140 -10.904 43.376 1.00 8.06 ? 45 LEU B CA 1 ATOM 3336 C C . LEU B 1 61 ? -22.128 -10.047 42.626 1.00 5.84 ? 45 LEU B C 1 ATOM 3337 O O . LEU B 1 61 ? -22.307 -8.836 42.491 1.00 7.07 ? 45 LEU B O 1 ATOM 3338 C CB . LEU B 1 61 ? -24.495 -10.867 42.665 1.00 6.78 ? 45 LEU B CB 1 ATOM 3339 C CG . LEU B 1 61 ? -24.494 -11.272 41.188 1.00 6.02 ? 45 LEU B CG 1 ATOM 3340 C CD1 . LEU B 1 61 ? -23.981 -12.693 41.018 1.00 2.96 ? 45 LEU B CD1 1 ATOM 3341 C CD2 . LEU B 1 61 ? -25.886 -11.131 40.592 1.00 5.14 ? 45 LEU B CD2 1 ATOM 3342 N N . LEU B 1 62 ? -21.068 -10.682 42.138 1.00 6.66 ? 46 LEU B N 1 ATOM 3343 C CA . LEU B 1 62 ? -19.964 -9.961 41.516 1.00 9.75 ? 46 LEU B CA 1 ATOM 3344 C C . LEU B 1 62 ? -20.098 -9.847 40.003 1.00 5.82 ? 46 LEU B C 1 ATOM 3345 O O . LEU B 1 62 ? -19.705 -8.836 39.420 1.00 16.88 ? 46 LEU B O 1 ATOM 3346 C CB . LEU B 1 62 ? -18.636 -10.647 41.846 1.00 9.70 ? 46 LEU B CB 1 ATOM 3347 C CG . LEU B 1 62 ? -18.130 -10.535 43.285 1.00 8.46 ? 46 LEU B CG 1 ATOM 3348 C CD1 . LEU B 1 62 ? -16.826 -11.301 43.436 1.00 8.56 ? 46 LEU B CD1 1 ATOM 3349 C CD2 . LEU B 1 62 ? -17.941 -9.082 43.687 1.00 11.31 ? 46 LEU B CD2 1 ATOM 3350 N N . LYS B 1 63 ? -20.643 -10.875 39.362 1.00 8.23 ? 47 LYS B N 1 ATOM 3351 C CA . LYS B 1 63 ? -20.582 -10.949 37.909 1.00 8.46 ? 47 LYS B CA 1 ATOM 3352 C C . LYS B 1 63 ? -21.487 -12.037 37.340 1.00 3.47 ? 47 LYS B C 1 ATOM 3353 O O . LYS B 1 63 ? -21.576 -13.133 37.890 1.00 5.24 ? 47 LYS B O 1 ATOM 3354 C CB . LYS B 1 63 ? -19.133 -11.216 37.497 1.00 10.51 ? 47 LYS B CB 1 ATOM 3355 C CG . LYS B 1 63 ? -18.827 -11.008 36.028 1.00 15.57 ? 47 LYS B CG 1 ATOM 3356 C CD . LYS B 1 63 ? -17.337 -11.188 35.770 1.00 19.59 ? 47 LYS B CD 1 ATOM 3357 C CE . LYS B 1 63 ? -17.006 -11.127 34.292 1.00 24.57 ? 47 LYS B CE 1 ATOM 3358 N NZ . LYS B 1 63 ? -15.549 -11.307 34.043 1.00 33.30 ? 47 LYS B NZ 1 ATOM 3359 N N . THR B 1 64 ? -22.160 -11.718 36.237 1.00 8.85 ? 48 THR B N 1 ATOM 3360 C CA . THR B 1 64 ? -22.949 -12.696 35.498 1.00 7.00 ? 48 THR B CA 1 ATOM 3361 C C . THR B 1 64 ? -22.316 -12.898 34.127 1.00 8.01 ? 48 THR B C 1 ATOM 3362 O O . THR B 1 64 ? -22.058 -11.934 33.407 1.00 9.00 ? 48 THR B O 1 ATOM 3363 C CB . THR B 1 64 ? -24.401 -12.235 35.323 1.00 9.71 ? 48 THR B CB 1 ATOM 3364 O OG1 . THR B 1 64 ? -24.990 -12.021 36.610 1.00 8.83 ? 48 THR B OG1 1 ATOM 3365 C CG2 . THR B 1 64 ? -25.208 -13.282 34.573 1.00 8.15 ? 48 THR B CG2 1 ATOM 3366 N N . GLU B 1 65 ? -22.073 -14.153 33.765 1.00 9.36 ? 49 GLU B N 1 ATOM 3367 C CA . GLU B 1 65 ? -21.261 -14.452 32.594 1.00 4.91 ? 49 GLU B CA 1 ATOM 3368 C C . GLU B 1 65 ? -21.905 -15.486 31.676 1.00 6.40 ? 49 GLU B C 1 ATOM 3369 O O . GLU B 1 65 ? -22.227 -16.596 32.100 1.00 7.25 ? 49 GLU B O 1 ATOM 3370 C CB . GLU B 1 65 ? -19.885 -14.944 33.047 1.00 10.02 ? 49 GLU B CB 1 ATOM 3371 C CG . GLU B 1 65 ? -18.775 -14.731 32.035 1.00 13.64 ? 49 GLU B CG 1 ATOM 3372 C CD . GLU B 1 65 ? -17.395 -14.882 32.646 1.00 20.73 ? 49 GLU B CD 1 ATOM 3373 O OE1 . GLU B 1 65 ? -17.241 -14.593 33.851 1.00 19.23 ? 49 GLU B OE1 1 ATOM 3374 O OE2 . GLU B 1 65 ? -16.464 -15.297 31.923 1.00 31.73 ? 49 GLU B OE2 1 ATOM 3375 N N . VAL B 1 66 ? -22.092 -15.104 30.416 1.00 13.53 ? 50 VAL B N 1 ATOM 3376 C CA . VAL B 1 66 ? -22.535 -16.028 29.378 1.00 8.09 ? 50 VAL B CA 1 ATOM 3377 C C . VAL B 1 66 ? -21.337 -16.390 28.509 1.00 7.60 ? 50 VAL B C 1 ATOM 3378 O O . VAL B 1 66 ? -20.751 -15.522 27.863 1.00 9.52 ? 50 VAL B O 1 ATOM 3379 C CB . VAL B 1 66 ? -23.638 -15.405 28.502 1.00 7.85 ? 50 VAL B CB 1 ATOM 3380 C CG1 . VAL B 1 66 ? -23.778 -16.161 27.190 1.00 5.95 ? 50 VAL B CG1 1 ATOM 3381 C CG2 . VAL B 1 66 ? -24.962 -15.377 29.253 1.00 9.73 ? 50 VAL B CG2 1 ATOM 3382 N N . THR B 1 67 ? -20.974 -17.669 28.491 1.00 14.21 ? 51 THR B N 1 ATOM 3383 C CA . THR B 1 67 ? -19.746 -18.094 27.826 1.00 9.12 ? 51 THR B CA 1 ATOM 3384 C C . THR B 1 67 ? -19.971 -19.234 26.835 1.00 8.12 ? 51 THR B C 1 ATOM 3385 O O . THR B 1 67 ? -20.629 -20.225 27.148 1.00 7.43 ? 51 THR B O 1 ATOM 3386 C CB . THR B 1 67 ? -18.688 -18.542 28.854 1.00 8.62 ? 51 THR B CB 1 ATOM 3387 O OG1 . THR B 1 67 ? -18.812 -17.758 30.047 1.00 15.91 ? 51 THR B OG1 1 ATOM 3388 C CG2 . THR B 1 67 ? -17.288 -18.379 28.284 1.00 19.75 ? 51 THR B CG2 1 ATOM 3389 N N . ASN B 1 68 ? -19.418 -19.075 25.635 1.00 10.69 ? 52 ASN B N 1 ATOM 3390 C CA . ASN B 1 68 ? -19.432 -20.122 24.616 1.00 9.61 ? 52 ASN B CA 1 ATOM 3391 C C . ASN B 1 68 ? -20.820 -20.685 24.307 1.00 6.76 ? 52 ASN B C 1 ATOM 3392 O O . ASN B 1 68 ? -21.007 -21.901 24.285 1.00 10.32 ? 52 ASN B O 1 ATOM 3393 C CB . ASN B 1 68 ? -18.490 -21.263 25.018 1.00 6.92 ? 52 ASN B CB 1 ATOM 3394 C CG . ASN B 1 68 ? -17.031 -20.936 24.754 1.00 8.73 ? 52 ASN B CG 1 ATOM 3395 O OD1 . ASN B 1 68 ? -16.705 -20.207 23.818 1.00 15.21 ? 52 ASN B OD1 1 ATOM 3396 N ND2 . ASN B 1 68 ? -16.144 -21.482 25.578 1.00 9.18 ? 52 ASN B ND2 1 ATOM 3397 N N . PRO B 1 69 ? -21.799 -19.801 24.063 1.00 6.07 ? 53 PRO B N 1 ATOM 3398 C CA . PRO B 1 69 ? -23.107 -20.265 23.584 1.00 7.89 ? 53 PRO B CA 1 ATOM 3399 C C . PRO B 1 69 ? -23.030 -20.804 22.155 1.00 9.51 ? 53 PRO B C 1 ATOM 3400 O O . PRO B 1 69 ? -22.142 -20.409 21.399 1.00 11.83 ? 53 PRO B O 1 ATOM 3401 C CB . PRO B 1 69 ? -23.976 -19.004 23.644 1.00 3.98 ? 53 PRO B CB 1 ATOM 3402 C CG . PRO B 1 69 ? -23.018 -17.865 23.633 1.00 6.52 ? 53 PRO B CG 1 ATOM 3403 C CD . PRO B 1 69 ? -21.788 -18.353 24.330 1.00 7.74 ? 53 PRO B CD 1 ATOM 3404 N N . ALA B 1 70 ? -23.951 -21.694 21.798 1.00 9.77 ? 54 ALA B N 1 ATOM 3405 C CA . ALA B 1 70 ? -23.933 -22.345 20.492 1.00 5.87 ? 54 ALA B CA 1 ATOM 3406 C C . ALA B 1 70 ? -24.533 -21.452 19.414 1.00 7.02 ? 54 ALA B C 1 ATOM 3407 O O . ALA B 1 70 ? -25.476 -20.704 19.669 1.00 12.86 ? 54 ALA B O 1 ATOM 3408 C CB . ALA B 1 70 ? -24.690 -23.661 20.556 1.00 8.46 ? 54 ALA B CB 1 ATOM 3409 N N . VAL B 1 71 ? -23.989 -21.544 18.206 1.00 9.42 ? 55 VAL B N 1 ATOM 3410 C CA . VAL B 1 71 ? -24.532 -20.815 17.068 1.00 5.96 ? 55 VAL B CA 1 ATOM 3411 C C . VAL B 1 71 ? -25.753 -21.545 16.523 1.00 4.07 ? 55 VAL B C 1 ATOM 3412 O O . VAL B 1 71 ? -25.757 -22.770 16.403 1.00 6.04 ? 55 VAL B O 1 ATOM 3413 C CB . VAL B 1 71 ? -23.490 -20.654 15.946 1.00 5.10 ? 55 VAL B CB 1 ATOM 3414 C CG1 . VAL B 1 71 ? -24.134 -20.072 14.696 1.00 4.94 ? 55 VAL B CG1 1 ATOM 3415 C CG2 . VAL B 1 71 ? -22.343 -19.772 16.411 1.00 8.37 ? 55 VAL B CG2 1 ATOM 3416 N N . LEU B 1 72 ? -26.786 -20.780 16.190 1.00 4.50 ? 56 LEU B N 1 ATOM 3417 C CA . LEU B 1 72 ? -28.037 -21.340 15.700 1.00 5.19 ? 56 LEU B CA 1 ATOM 3418 C C . LEU B 1 72 ? -28.025 -21.322 14.177 1.00 5.80 ? 56 LEU B C 1 ATOM 3419 O O . LEU B 1 72 ? -28.249 -22.342 13.526 1.00 5.43 ? 56 LEU B O 1 ATOM 3420 C CB . LEU B 1 72 ? -29.212 -20.515 16.226 1.00 3.60 ? 56 LEU B CB 1 ATOM 3421 C CG . LEU B 1 72 ? -30.549 -21.233 16.405 1.00 5.39 ? 56 LEU B CG 1 ATOM 3422 C CD1 . LEU B 1 72 ? -30.430 -22.353 17.429 1.00 6.89 ? 56 LEU B CD1 1 ATOM 3423 C CD2 . LEU B 1 72 ? -31.616 -20.235 16.821 1.00 3.78 ? 56 LEU B CD2 1 ATOM 3424 N N . ARG B 1 73 ? -27.759 -20.144 13.625 1.00 6.15 ? 57 ARG B N 1 ATOM 3425 C CA . ARG B 1 73 ? -27.613 -19.963 12.189 1.00 5.46 ? 57 ARG B CA 1 ATOM 3426 C C . ARG B 1 73 ? -26.602 -18.856 11.930 1.00 7.24 ? 57 ARG B C 1 ATOM 3427 O O . ARG B 1 73 ? -26.285 -18.071 12.824 1.00 8.67 ? 57 ARG B O 1 ATOM 3428 C CB . ARG B 1 73 ? -28.946 -19.570 11.550 1.00 6.80 ? 57 ARG B CB 1 ATOM 3429 C CG . ARG B 1 73 ? -29.984 -20.677 11.453 1.00 11.19 ? 57 ARG B CG 1 ATOM 3430 C CD . ARG B 1 73 ? -31.212 -20.161 10.722 1.00 13.16 ? 57 ARG B CD 1 ATOM 3431 N NE . ARG B 1 73 ? -32.293 -21.138 10.644 1.00 11.81 ? 57 ARG B NE 1 ATOM 3432 C CZ . ARG B 1 73 ? -33.454 -20.911 10.038 1.00 9.40 ? 57 ARG B CZ 1 ATOM 3433 N NH1 . ARG B 1 73 ? -33.682 -19.742 9.456 1.00 10.93 ? 57 ARG B NH1 1 ATOM 3434 N NH2 . ARG B 1 73 ? -34.390 -21.848 10.007 1.00 16.48 ? 57 ARG B NH2 1 ATOM 3435 N N . LYS B 1 74 ? -26.105 -18.791 10.701 1.00 12.69 ? 58 LYS B N 1 ATOM 3436 C CA . LYS B 1 74 ? -25.245 -17.696 10.274 1.00 13.05 ? 58 LYS B CA 1 ATOM 3437 C C . LYS B 1 74 ? -25.904 -17.011 9.087 1.00 11.59 ? 58 LYS B C 1 ATOM 3438 O O . LYS B 1 74 ? -26.256 -17.666 8.109 1.00 14.30 ? 58 LYS B O 1 ATOM 3439 C CB . LYS B 1 74 ? -23.864 -18.212 9.870 1.00 12.83 ? 58 LYS B CB 1 ATOM 3440 C CG . LYS B 1 74 ? -23.197 -19.095 10.905 1.00 11.03 ? 58 LYS B CG 1 ATOM 3441 C CD . LYS B 1 74 ? -21.943 -19.745 10.340 1.00 29.93 ? 58 LYS B CD 1 ATOM 3442 C CE . LYS B 1 74 ? -21.231 -20.596 11.381 1.00 27.98 ? 58 LYS B CE 1 ATOM 3443 N NZ . LYS B 1 74 ? -20.089 -21.347 10.791 1.00 30.03 ? 58 LYS B NZ 1 ATOM 3444 N N . LEU B 1 75 ? -26.082 -15.697 9.179 1.00 14.34 ? 59 LEU B N 1 ATOM 3445 C CA . LEU B 1 75 ? -26.665 -14.930 8.085 1.00 12.62 ? 59 LEU B CA 1 ATOM 3446 C C . LEU B 1 75 ? -25.588 -14.119 7.377 1.00 12.41 ? 59 LEU B C 1 ATOM 3447 O O . LEU B 1 75 ? -24.645 -13.641 8.007 1.00 13.81 ? 59 LEU B O 1 ATOM 3448 C CB . LEU B 1 75 ? -27.759 -13.994 8.601 1.00 14.15 ? 59 LEU B CB 1 ATOM 3449 C CG . LEU B 1 75 ? -28.899 -14.635 9.396 1.00 6.69 ? 59 LEU B CG 1 ATOM 3450 C CD1 . LEU B 1 75 ? -29.995 -13.613 9.659 1.00 8.22 ? 59 LEU B CD1 1 ATOM 3451 C CD2 . LEU B 1 75 ? -29.458 -15.846 8.669 1.00 11.39 ? 59 LEU B CD2 1 ATOM 3452 N N . CYS B 1 76 ? -25.730 -13.973 6.065 1.00 12.74 ? 60 CYS B N 1 ATOM 3453 C CA . CYS B 1 76 ? -24.771 -13.216 5.275 1.00 13.95 ? 60 CYS B CA 1 ATOM 3454 C C . CYS B 1 76 ? -25.350 -11.856 4.910 1.00 9.52 ? 60 CYS B C 1 ATOM 3455 O O . CYS B 1 76 ? -26.420 -11.767 4.310 1.00 13.31 ? 60 CYS B O 1 ATOM 3456 C CB . CYS B 1 76 ? -24.404 -13.983 4.005 1.00 13.87 ? 60 CYS B CB 1 ATOM 3457 S SG . CYS B 1 76 ? -22.853 -13.448 3.234 1.00 13.93 ? 60 CYS B SG 1 ATOM 3458 N N . ILE B 1 77 ? -24.636 -10.796 5.274 1.00 12.98 ? 61 ILE B N 1 ATOM 3459 C CA . ILE B 1 77 ? -25.084 -9.438 4.983 1.00 17.60 ? 61 ILE B CA 1 ATOM 3460 C C . ILE B 1 77 ? -24.304 -8.844 3.812 1.00 19.39 ? 61 ILE B C 1 ATOM 3461 O O . ILE B 1 77 ? -24.687 -7.814 3.263 1.00 21.29 ? 61 ILE B O 1 ATOM 3462 C CB . ILE B 1 77 ? -24.969 -8.513 6.218 1.00 16.38 ? 61 ILE B CB 1 ATOM 3463 C CG1 . ILE B 1 77 ? -23.547 -8.539 6.784 1.00 15.47 ? 61 ILE B CG1 1 ATOM 3464 C CG2 . ILE B 1 77 ? -25.984 -8.926 7.283 1.00 14.72 ? 61 ILE B CG2 1 ATOM 3465 C CD1 . ILE B 1 77 ? -23.353 -7.644 7.977 1.00 19.01 ? 61 ILE B CD1 1 ATOM 3466 N N . GLU B 1 78 ? -23.215 -9.500 3.426 1.00 19.13 ? 62 GLU B N 1 ATOM 3467 C CA . GLU B 1 78 ? -22.444 -9.065 2.268 1.00 22.91 ? 62 GLU B CA 1 ATOM 3468 C C . GLU B 1 78 ? -21.754 -10.256 1.619 1.00 21.60 ? 62 GLU B C 1 ATOM 3469 O O . GLU B 1 78 ? -21.102 -11.052 2.295 1.00 21.64 ? 62 GLU B O 1 ATOM 3470 C CB . GLU B 1 78 ? -21.401 -8.023 2.671 1.00 20.95 ? 62 GLU B CB 1 ATOM 3471 C CG . GLU B 1 78 ? -20.796 -7.284 1.491 1.00 21.81 ? 62 GLU B CG 1 ATOM 3472 C CD . GLU B 1 78 ? -19.535 -6.528 1.856 1.00 27.24 ? 62 GLU B CD 1 ATOM 3473 O OE1 . GLU B 1 78 ? -18.806 -6.987 2.760 1.00 26.63 ? 62 GLU B OE1 1 ATOM 3474 O OE2 . GLU B 1 78 ? -19.275 -5.471 1.243 1.00 41.64 ? 62 GLU B OE2 1 ATOM 3475 N N . ALA B 1 79 ? -21.898 -10.371 0.303 1.00 22.75 ? 63 ALA B N 1 ATOM 3476 C CA . ALA B 1 79 ? -21.269 -11.454 -0.441 1.00 18.69 ? 63 ALA B CA 1 ATOM 3477 C C . ALA B 1 79 ? -20.501 -10.915 -1.642 1.00 25.08 ? 63 ALA B C 1 ATOM 3478 O O . ALA B 1 79 ? -20.795 -9.830 -2.143 1.00 28.31 ? 63 ALA B O 1 ATOM 3479 C CB . ALA B 1 79 ? -22.318 -12.454 -0.896 1.00 24.10 ? 63 ALA B CB 1 ATOM 3480 N N . LYS B 1 80 ? -19.512 -11.680 -2.092 1.00 26.03 ? 64 LYS B N 1 ATOM 3481 C CA . LYS B 1 80 ? -18.755 -11.339 -3.289 1.00 18.60 ? 64 LYS B CA 1 ATOM 3482 C C . LYS B 1 80 ? -18.842 -12.467 -4.304 1.00 21.57 ? 64 LYS B C 1 ATOM 3483 O O . LYS B 1 80 ? -18.583 -13.626 -3.984 1.00 26.15 ? 64 LYS B O 1 ATOM 3484 C CB . LYS B 1 80 ? -17.290 -11.070 -2.947 1.00 28.21 ? 64 LYS B CB 1 ATOM 3485 C CG . LYS B 1 80 ? -17.002 -9.645 -2.506 1.00 29.96 ? 64 LYS B CG 1 ATOM 3486 C CD . LYS B 1 80 ? -15.506 -9.399 -2.393 1.00 33.83 ? 64 LYS B CD 1 ATOM 3487 C CE . LYS B 1 80 ? -15.201 -7.970 -1.981 1.00 39.48 ? 64 LYS B CE 1 ATOM 3488 N NZ . LYS B 1 80 ? -13.767 -7.625 -2.192 1.00 38.04 ? 64 LYS B NZ 1 ATOM 3489 N N . ILE B 1 81 ? -19.214 -12.119 -5.530 1.00 28.06 ? 65 ILE B N 1 ATOM 3490 C CA . ILE B 1 81 ? -19.294 -13.093 -6.608 1.00 24.36 ? 65 ILE B CA 1 ATOM 3491 C C . ILE B 1 81 ? -18.013 -13.076 -7.434 1.00 29.15 ? 65 ILE B C 1 ATOM 3492 O O . ILE B 1 81 ? -17.401 -12.026 -7.633 1.00 25.77 ? 65 ILE B O 1 ATOM 3493 C CB . ILE B 1 81 ? -20.501 -12.821 -7.518 1.00 26.53 ? 65 ILE B CB 1 ATOM 3494 C CG1 . ILE B 1 81 ? -21.782 -13.359 -6.872 1.00 24.80 ? 65 ILE B CG1 1 ATOM 3495 C CG2 . ILE B 1 81 ? -20.296 -13.464 -8.874 1.00 27.43 ? 65 ILE B CG2 1 ATOM 3496 C CD1 . ILE B 1 81 ? -21.859 -14.878 -6.777 1.00 25.05 ? 65 ILE B CD1 1 ATOM 3497 N N . SER B 1 82 ? -17.604 -14.250 -7.903 1.00 24.37 ? 66 SER B N 1 ATOM 3498 C CA . SER B 1 82 ? -16.380 -14.377 -8.680 1.00 20.75 ? 66 SER B CA 1 ATOM 3499 C C . SER B 1 82 ? -16.466 -15.558 -9.636 1.00 24.68 ? 66 SER B C 1 ATOM 3500 O O . SER B 1 82 ? -17.257 -16.479 -9.429 1.00 21.79 ? 66 SER B O 1 ATOM 3501 C CB . SER B 1 82 ? -15.179 -14.557 -7.748 1.00 22.04 ? 66 SER B CB 1 ATOM 3502 O OG . SER B 1 82 ? -15.017 -13.440 -6.894 1.00 38.51 ? 66 SER B OG 1 ATOM 3503 N N . ASN B 1 83 ? -15.644 -15.525 -10.680 1.00 29.52 ? 67 ASN B N 1 ATOM 3504 C CA . ASN B 1 83 ? -15.534 -16.639 -11.613 1.00 24.95 ? 67 ASN B CA 1 ATOM 3505 C C . ASN B 1 83 ? -16.886 -17.024 -12.200 1.00 22.26 ? 67 ASN B C 1 ATOM 3506 O O . ASN B 1 83 ? -17.296 -18.183 -12.145 1.00 18.39 ? 67 ASN B O 1 ATOM 3507 C CB . ASN B 1 83 ? -14.897 -17.836 -10.912 1.00 23.59 ? 67 ASN B CB 1 ATOM 3508 C CG . ASN B 1 83 ? -13.659 -17.450 -10.131 1.00 36.30 ? 67 ASN B CG 1 ATOM 3509 O OD1 . ASN B 1 83 ? -13.735 -17.164 -8.939 1.00 41.41 ? 67 ASN B OD1 1 ATOM 3510 N ND2 . ASN B 1 83 ? -12.515 -17.420 -10.803 1.00 44.12 ? 67 ASN B ND2 1 ATOM 3511 N N . THR B 1 84 ? -17.574 -16.038 -12.765 1.00 26.03 ? 68 THR B N 1 ATOM 3512 C CA . THR B 1 84 ? -18.868 -16.264 -13.392 1.00 20.57 ? 68 THR B CA 1 ATOM 3513 C C . THR B 1 84 ? -18.645 -16.901 -14.759 1.00 28.89 ? 68 THR B C 1 ATOM 3514 O O . THR B 1 84 ? -17.975 -16.324 -15.615 1.00 32.57 ? 68 THR B O 1 ATOM 3515 C CB . THR B 1 84 ? -19.646 -14.945 -13.568 1.00 16.78 ? 68 THR B CB 1 ATOM 3516 O OG1 . THR B 1 84 ? -19.691 -14.235 -12.323 1.00 13.39 ? 68 THR B OG1 1 ATOM 3517 C CG2 . THR B 1 84 ? -21.066 -15.220 -14.038 1.00 24.13 ? 68 THR B CG2 1 ATOM 3518 N N . THR B 1 85 ? -19.197 -18.094 -14.955 1.00 30.05 ? 69 THR B N 1 ATOM 3519 C CA . THR B 1 85 ? -18.983 -18.844 -16.187 1.00 16.98 ? 69 THR B CA 1 ATOM 3520 C C . THR B 1 85 ? -20.307 -19.367 -16.732 1.00 19.67 ? 69 THR B C 1 ATOM 3521 O O . THR B 1 85 ? -21.200 -19.733 -15.968 1.00 20.95 ? 69 THR B O 1 ATOM 3522 C CB . THR B 1 85 ? -18.027 -20.028 -15.958 1.00 21.36 ? 69 THR B CB 1 ATOM 3523 O OG1 . THR B 1 85 ? -18.662 -21.008 -15.128 1.00 31.54 ? 69 THR B OG1 1 ATOM 3524 C CG2 . THR B 1 85 ? -16.748 -19.553 -15.292 1.00 33.50 ? 69 THR B CG2 1 ATOM 3525 N N . THR B 1 86 ? -20.420 -19.409 -18.056 1.00 20.15 ? 70 THR B N 1 ATOM 3526 C CA . THR B 1 86 ? -21.664 -19.799 -18.709 1.00 21.17 ? 70 THR B CA 1 ATOM 3527 C C . THR B 1 86 ? -21.448 -20.934 -19.708 1.00 20.53 ? 70 THR B C 1 ATOM 3528 O O . THR B 1 86 ? -20.375 -21.063 -20.298 1.00 29.31 ? 70 THR B O 1 ATOM 3529 C CB . THR B 1 86 ? -22.295 -18.606 -19.458 1.00 19.80 ? 70 THR B CB 1 ATOM 3530 O OG1 . THR B 1 86 ? -22.483 -17.512 -18.553 1.00 16.44 ? 70 THR B OG1 1 ATOM 3531 C CG2 . THR B 1 86 ? -23.635 -18.994 -20.060 1.00 20.64 ? 70 THR B CG2 1 ATOM 3532 N N . ASP B 1 87 ? -22.480 -21.753 -19.885 1.00 20.99 ? 71 ASP B N 1 ATOM 3533 C CA . ASP B 1 87 ? -22.478 -22.818 -20.883 1.00 17.74 ? 71 ASP B CA 1 ATOM 3534 C C . ASP B 1 87 ? -23.804 -22.776 -21.630 1.00 17.89 ? 71 ASP B C 1 ATOM 3535 O O . ASP B 1 87 ? -24.854 -22.567 -21.023 1.00 24.35 ? 71 ASP B O 1 ATOM 3536 C CB . ASP B 1 87 ? -22.297 -24.182 -20.216 1.00 20.81 ? 71 ASP B CB 1 ATOM 3537 C CG . ASP B 1 87 ? -22.268 -25.323 -21.217 1.00 27.98 ? 71 ASP B CG 1 ATOM 3538 O OD1 . ASP B 1 87 ? -23.353 -25.792 -21.620 1.00 28.49 ? 71 ASP B OD1 1 ATOM 3539 O OD2 . ASP B 1 87 ? -21.159 -25.755 -21.596 1.00 34.66 ? 71 ASP B OD2 1 ATOM 3540 N N . SER B 1 88 ? -23.761 -22.969 -22.945 1.00 20.44 ? 72 SER B N 1 ATOM 3541 C CA . SER B 1 88 ? -24.965 -22.856 -23.759 1.00 21.95 ? 72 SER B CA 1 ATOM 3542 C C . SER B 1 88 ? -25.031 -23.903 -24.865 1.00 25.75 ? 72 SER B C 1 ATOM 3543 O O . SER B 1 88 ? -24.006 -24.337 -25.394 1.00 30.29 ? 72 SER B O 1 ATOM 3544 C CB . SER B 1 88 ? -25.056 -21.457 -24.369 1.00 25.00 ? 72 SER B CB 1 ATOM 3545 O OG . SER B 1 88 ? -26.149 -21.361 -25.265 1.00 27.41 ? 72 SER B OG 1 ATOM 3546 N N . ARG B 1 89 ? -26.253 -24.298 -25.205 1.00 24.29 ? 73 ARG B N 1 ATOM 3547 C CA . ARG B 1 89 ? -26.495 -25.255 -26.273 1.00 19.90 ? 73 ARG B CA 1 ATOM 3548 C C . ARG B 1 89 ? -27.399 -24.615 -27.316 1.00 21.63 ? 73 ARG B C 1 ATOM 3549 O O . ARG B 1 89 ? -28.197 -23.734 -26.998 1.00 22.31 ? 73 ARG B O 1 ATOM 3550 C CB . ARG B 1 89 ? -27.166 -26.508 -25.713 1.00 23.63 ? 73 ARG B CB 1 ATOM 3551 C CG . ARG B 1 89 ? -26.534 -27.029 -24.432 1.00 26.37 ? 73 ARG B CG 1 ATOM 3552 C CD . ARG B 1 89 ? -25.143 -27.580 -24.679 1.00 23.01 ? 73 ARG B CD 1 ATOM 3553 N NE . ARG B 1 89 ? -25.186 -28.930 -25.232 1.00 27.31 ? 73 ARG B NE 1 ATOM 3554 C CZ . ARG B 1 89 ? -24.138 -29.561 -25.751 1.00 26.52 ? 73 ARG B CZ 1 ATOM 3555 N NH1 . ARG B 1 89 ? -22.954 -28.965 -25.804 1.00 23.37 ? 73 ARG B NH1 1 ATOM 3556 N NH2 . ARG B 1 89 ? -24.274 -30.790 -26.228 1.00 25.49 ? 73 ARG B NH2 1 ATOM 3557 N N . CYS B 1 90 ? -27.269 -25.054 -28.562 1.00 27.93 ? 74 CYS B N 1 ATOM 3558 C CA . CYS B 1 90 ? -28.117 -24.551 -29.632 1.00 21.88 ? 74 CYS B CA 1 ATOM 3559 C C . CYS B 1 90 ? -29.466 -25.257 -29.598 1.00 25.99 ? 74 CYS B C 1 ATOM 3560 O O . CYS B 1 90 ? -29.612 -26.286 -28.935 1.00 23.84 ? 74 CYS B O 1 ATOM 3561 C CB . CYS B 1 90 ? -27.444 -24.764 -30.989 1.00 17.03 ? 74 CYS B CB 1 ATOM 3562 S SG . CYS B 1 90 ? -26.072 -23.641 -31.314 1.00 19.95 ? 74 CYS B SG 1 ATOM 3563 N N . PRO B 1 91 ? -30.464 -24.699 -30.301 1.00 23.94 ? 75 PRO B N 1 ATOM 3564 C CA . PRO B 1 91 ? -31.762 -25.371 -30.387 1.00 21.05 ? 75 PRO B CA 1 ATOM 3565 C C . PRO B 1 91 ? -31.593 -26.807 -30.866 1.00 28.67 ? 75 PRO B C 1 ATOM 3566 O O . PRO B 1 91 ? -31.042 -27.033 -31.940 1.00 32.33 ? 75 PRO B O 1 ATOM 3567 C CB . PRO B 1 91 ? -32.519 -24.538 -31.424 1.00 18.01 ? 75 PRO B CB 1 ATOM 3568 C CG . PRO B 1 91 ? -31.897 -23.194 -31.355 1.00 20.27 ? 75 PRO B CG 1 ATOM 3569 C CD . PRO B 1 91 ? -30.450 -23.427 -31.042 1.00 21.61 ? 75 PRO B CD 1 ATOM 3570 N N . THR B 1 92 ? -32.057 -27.757 -30.061 1.00 29.15 ? 76 THR B N 1 ATOM 3571 C CA . THR B 1 92 ? -32.035 -29.184 -30.399 1.00 26.63 ? 76 THR B CA 1 ATOM 3572 C C . THR B 1 92 ? -30.782 -29.915 -29.910 1.00 28.39 ? 76 THR B C 1 ATOM 3573 O O . THR B 1 92 ? -30.683 -31.133 -30.058 1.00 21.60 ? 76 THR B O 1 ATOM 3574 C CB . THR B 1 92 ? -32.201 -29.467 -31.923 1.00 28.19 ? 76 THR B CB 1 ATOM 3575 O OG1 . THR B 1 92 ? -30.963 -29.257 -32.621 1.00 27.72 ? 76 THR B OG1 1 ATOM 3576 C CG2 . THR B 1 92 ? -33.332 -28.630 -32.537 1.00 27.82 ? 76 THR B CG2 1 ATOM 3577 N N . GLN B 1 93 ? -29.836 -29.187 -29.324 1.00 25.76 ? 77 GLN B N 1 ATOM 3578 C CA . GLN B 1 93 ? -28.586 -29.800 -28.876 1.00 21.30 ? 77 GLN B CA 1 ATOM 3579 C C . GLN B 1 93 ? -28.590 -30.138 -27.387 1.00 22.27 ? 77 GLN B C 1 ATOM 3580 O O . GLN B 1 93 ? -27.533 -30.330 -26.786 1.00 31.08 ? 77 GLN B O 1 ATOM 3581 C CB . GLN B 1 93 ? -27.401 -28.890 -29.202 1.00 26.24 ? 77 GLN B CB 1 ATOM 3582 C CG . GLN B 1 93 ? -27.403 -28.397 -30.635 1.00 27.57 ? 77 GLN B CG 1 ATOM 3583 C CD . GLN B 1 93 ? -27.943 -29.435 -31.599 1.00 33.48 ? 77 GLN B CD 1 ATOM 3584 O OE1 . GLN B 1 93 ? -29.047 -29.291 -32.122 1.00 37.54 ? 77 GLN B OE1 1 ATOM 3585 N NE2 . GLN B 1 93 ? -27.173 -30.491 -31.831 1.00 28.69 ? 77 GLN B NE2 1 ATOM 3586 N N . GLY B 1 94 ? -29.779 -30.214 -26.796 1.00 28.42 ? 78 GLY B N 1 ATOM 3587 C CA . GLY B 1 94 ? -29.915 -30.651 -25.418 1.00 27.93 ? 78 GLY B CA 1 ATOM 3588 C C . GLY B 1 94 ? -29.702 -29.551 -24.398 1.00 29.10 ? 78 GLY B C 1 ATOM 3589 O O . GLY B 1 94 ? -29.511 -28.386 -24.748 1.00 24.11 ? 78 GLY B O 1 ATOM 3590 N N . GLU B 1 95 ? -29.738 -29.931 -23.125 1.00 33.51 ? 79 GLU B N 1 ATOM 3591 C CA . GLU B 1 95 ? -29.599 -28.977 -22.033 1.00 25.84 ? 79 GLU B CA 1 ATOM 3592 C C . GLU B 1 95 ? -28.132 -28.636 -21.786 1.00 25.12 ? 79 GLU B C 1 ATOM 3593 O O . GLU B 1 95 ? -27.245 -29.459 -22.013 1.00 29.02 ? 79 GLU B O 1 ATOM 3594 C CB . GLU B 1 95 ? -30.233 -29.539 -20.758 1.00 32.31 ? 79 GLU B CB 1 ATOM 3595 C CG . GLU B 1 95 ? -31.189 -28.578 -20.062 1.00 35.51 ? 79 GLU B CG 1 ATOM 3596 C CD . GLU B 1 95 ? -32.407 -28.241 -20.904 1.00 39.33 ? 79 GLU B CD 1 ATOM 3597 O OE1 . GLU B 1 95 ? -32.552 -28.810 -22.006 1.00 33.87 ? 79 GLU B OE1 1 ATOM 3598 O OE2 . GLU B 1 95 ? -33.221 -27.403 -20.461 1.00 37.31 ? 79 GLU B OE2 1 ATOM 3599 N N . ALA B 1 96 ? -27.886 -27.415 -21.322 1.00 22.63 ? 80 ALA B N 1 ATOM 3600 C CA . ALA B 1 96 ? -26.530 -26.959 -21.040 1.00 25.43 ? 80 ALA B CA 1 ATOM 3601 C C . ALA B 1 96 ? -26.015 -27.595 -19.756 1.00 27.24 ? 80 ALA B C 1 ATOM 3602 O O . ALA B 1 96 ? -26.781 -28.181 -18.992 1.00 22.29 ? 80 ALA B O 1 ATOM 3603 C CB . ALA B 1 96 ? -26.496 -25.442 -20.930 1.00 26.23 ? 80 ALA B CB 1 ATOM 3604 N N . THR B 1 97 ? -24.713 -27.471 -19.522 1.00 32.36 ? 81 THR B N 1 ATOM 3605 C CA . THR B 1 97 ? -24.089 -28.061 -18.346 1.00 27.12 ? 81 THR B CA 1 ATOM 3606 C C . THR B 1 97 ? -22.797 -27.329 -18.003 1.00 19.66 ? 81 THR B C 1 ATOM 3607 O O . THR B 1 97 ? -22.057 -26.905 -18.891 1.00 24.58 ? 81 THR B O 1 ATOM 3608 C CB . THR B 1 97 ? -23.783 -29.558 -18.568 1.00 24.68 ? 81 THR B CB 1 ATOM 3609 O OG1 . THR B 1 97 ? -24.012 -30.287 -17.354 1.00 30.33 ? 81 THR B OG1 1 ATOM 3610 C CG2 . THR B 1 97 ? -22.340 -29.761 -19.025 1.00 25.92 ? 81 THR B CG2 1 ATOM 3611 N N . LEU B 1 98 ? -22.537 -27.180 -16.708 1.00 20.23 ? 82 LEU B N 1 ATOM 3612 C CA . LEU B 1 98 ? -21.342 -26.495 -16.230 1.00 24.87 ? 82 LEU B CA 1 ATOM 3613 C C . LEU B 1 98 ? -20.636 -27.322 -15.165 1.00 24.04 ? 82 LEU B C 1 ATOM 3614 O O . LEU B 1 98 ? -21.279 -27.946 -14.323 1.00 24.95 ? 82 LEU B O 1 ATOM 3615 C CB . LEU B 1 98 ? -21.708 -25.128 -15.650 1.00 23.51 ? 82 LEU B CB 1 ATOM 3616 C CG . LEU B 1 98 ? -21.666 -23.937 -16.607 1.00 13.10 ? 82 LEU B CG 1 ATOM 3617 C CD1 . LEU B 1 98 ? -22.205 -22.694 -15.919 1.00 15.80 ? 82 LEU B CD1 1 ATOM 3618 C CD2 . LEU B 1 98 ? -20.250 -23.695 -17.105 1.00 18.80 ? 82 LEU B CD2 1 ATOM 3619 N N . VAL B 1 99 ? -19.309 -27.322 -15.205 1.00 29.86 ? 83 VAL B N 1 ATOM 3620 C CA . VAL B 1 99 ? -18.519 -27.976 -14.171 1.00 27.41 ? 83 VAL B CA 1 ATOM 3621 C C . VAL B 1 99 ? -18.842 -27.349 -12.824 1.00 23.72 ? 83 VAL B C 1 ATOM 3622 O O . VAL B 1 99 ? -18.777 -28.004 -11.787 1.00 27.56 ? 83 VAL B O 1 ATOM 3623 C CB . VAL B 1 99 ? -17.009 -27.832 -14.435 1.00 29.11 ? 83 VAL B CB 1 ATOM 3624 C CG1 . VAL B 1 99 ? -16.509 -26.455 -13.992 1.00 36.73 ? 83 VAL B CG1 1 ATOM 3625 C CG2 . VAL B 1 99 ? -16.238 -28.933 -13.724 1.00 28.78 ? 83 VAL B CG2 1 ATOM 3626 N N . GLU B 1 100 ? -19.189 -26.068 -12.850 1.00 21.87 ? 84 GLU B N 1 ATOM 3627 C CA . GLU B 1 100 ? -19.522 -25.337 -11.637 1.00 23.53 ? 84 GLU B CA 1 ATOM 3628 C C . GLU B 1 100 ? -20.801 -25.866 -10.988 1.00 24.60 ? 84 GLU B C 1 ATOM 3629 O O . GLU B 1 100 ? -21.047 -25.619 -9.806 1.00 21.84 ? 84 GLU B O 1 ATOM 3630 C CB . GLU B 1 100 ? -19.664 -23.858 -11.948 1.00 27.05 ? 84 GLU B CB 1 ATOM 3631 N N . GLU B 1 101 ? -21.609 -26.589 -11.758 1.00 25.80 ? 85 GLU B N 1 ATOM 3632 C CA . GLU B 1 101 ? -22.867 -27.131 -11.253 1.00 25.54 ? 85 GLU B CA 1 ATOM 3633 C C . GLU B 1 101 ? -22.688 -27.936 -9.968 1.00 27.08 ? 85 GLU B C 1 ATOM 3634 O O . GLU B 1 101 ? -23.610 -28.020 -9.156 1.00 30.94 ? 85 GLU B O 1 ATOM 3635 C CB . GLU B 1 101 ? -23.532 -28.021 -12.302 1.00 23.81 ? 85 GLU B CB 1 ATOM 3636 C CG . GLU B 1 101 ? -24.213 -27.266 -13.417 1.00 26.40 ? 85 GLU B CG 1 ATOM 3637 C CD . GLU B 1 101 ? -25.046 -28.174 -14.299 1.00 30.62 ? 85 GLU B CD 1 ATOM 3638 O OE1 . GLU B 1 101 ? -24.462 -28.909 -15.122 1.00 25.42 ? 85 GLU B OE1 1 ATOM 3639 O OE2 . GLU B 1 101 ? -26.287 -28.154 -14.166 1.00 38.31 ? 85 GLU B OE2 1 ATOM 3640 N N . GLN B 1 102 ? -21.512 -28.530 -9.787 1.00 30.28 ? 86 GLN B N 1 ATOM 3641 C CA . GLN B 1 102 ? -21.306 -29.463 -8.681 1.00 32.44 ? 86 GLN B CA 1 ATOM 3642 C C . GLN B 1 102 ? -20.845 -28.746 -7.415 1.00 29.98 ? 86 GLN B C 1 ATOM 3643 O O . GLN B 1 102 ? -21.453 -28.898 -6.358 1.00 29.72 ? 86 GLN B O 1 ATOM 3644 C CB . GLN B 1 102 ? -20.303 -30.569 -9.046 1.00 41.22 ? 86 GLN B CB 1 ATOM 3645 C CG . GLN B 1 102 ? -19.804 -30.582 -10.487 1.00 34.30 ? 86 GLN B CG 1 ATOM 3646 C CD . GLN B 1 102 ? -20.910 -30.530 -11.528 1.00 33.44 ? 86 GLN B CD 1 ATOM 3647 O OE1 . GLN B 1 102 ? -20.678 -30.118 -12.663 1.00 34.68 ? 86 GLN B OE1 1 ATOM 3648 N NE2 . GLN B 1 102 ? -22.114 -30.952 -11.152 1.00 33.86 ? 86 GLN B NE2 1 ATOM 3649 N N . ASP B 1 103 ? -19.770 -27.972 -7.525 1.00 28.83 ? 87 ASP B N 1 ATOM 3650 C CA . ASP B 1 103 ? -19.221 -27.265 -6.373 1.00 23.77 ? 87 ASP B CA 1 ATOM 3651 C C . ASP B 1 103 ? -20.284 -26.371 -5.743 1.00 29.35 ? 87 ASP B C 1 ATOM 3652 O O . ASP B 1 103 ? -20.803 -25.454 -6.380 1.00 29.31 ? 87 ASP B O 1 ATOM 3653 C CB . ASP B 1 103 ? -17.988 -26.450 -6.779 1.00 28.75 ? 87 ASP B CB 1 ATOM 3654 C CG . ASP B 1 103 ? -17.408 -25.653 -5.627 1.00 34.95 ? 87 ASP B CG 1 ATOM 3655 O OD1 . ASP B 1 103 ? -17.709 -25.986 -4.462 1.00 37.07 ? 87 ASP B OD1 1 ATOM 3656 O OD2 . ASP B 1 103 ? -16.644 -24.698 -5.887 1.00 32.02 ? 87 ASP B OD2 1 ATOM 3657 N N . THR B 1 104 ? -20.602 -26.655 -4.484 1.00 36.01 ? 88 THR B N 1 ATOM 3658 C CA . THR B 1 104 ? -21.682 -25.971 -3.781 1.00 33.13 ? 88 THR B CA 1 ATOM 3659 C C . THR B 1 104 ? -21.413 -24.484 -3.573 1.00 36.27 ? 88 THR B C 1 ATOM 3660 O O . THR B 1 104 ? -22.328 -23.724 -3.251 1.00 33.51 ? 88 THR B O 1 ATOM 3661 C CB . THR B 1 104 ? -21.947 -26.618 -2.410 1.00 33.22 ? 88 THR B CB 1 ATOM 3662 O OG1 . THR B 1 104 ? -20.700 -26.942 -1.782 1.00 35.39 ? 88 THR B OG1 1 ATOM 3663 C CG2 . THR B 1 104 ? -22.773 -27.883 -2.570 1.00 32.46 ? 88 THR B CG2 1 ATOM 3664 N N . ASN B 1 105 ? -20.166 -24.066 -3.756 1.00 34.00 ? 89 ASN B N 1 ATOM 3665 C CA . ASN B 1 105 ? -19.820 -22.656 -3.621 1.00 26.85 ? 89 ASN B CA 1 ATOM 3666 C C . ASN B 1 105 ? -20.299 -21.834 -4.814 1.00 24.35 ? 89 ASN B C 1 ATOM 3667 O O . ASN B 1 105 ? -20.111 -20.619 -4.855 1.00 30.02 ? 89 ASN B O 1 ATOM 3668 C CB . ASN B 1 105 ? -18.311 -22.484 -3.440 1.00 30.45 ? 89 ASN B CB 1 ATOM 3669 C CG . ASN B 1 105 ? -17.801 -23.114 -2.157 1.00 33.98 ? 89 ASN B CG 1 ATOM 3670 O OD1 . ASN B 1 105 ? -17.820 -22.491 -1.095 1.00 36.42 ? 89 ASN B OD1 1 ATOM 3671 N ND2 . ASN B 1 105 ? -17.339 -24.355 -2.249 1.00 43.65 ? 89 ASN B ND2 1 ATOM 3672 N N . PHE B 1 106 ? -20.920 -22.499 -5.784 1.00 26.60 ? 90 PHE B N 1 ATOM 3673 C CA . PHE B 1 106 ? -21.476 -21.809 -6.942 1.00 26.51 ? 90 PHE B CA 1 ATOM 3674 C C . PHE B 1 106 ? -22.987 -21.697 -6.860 1.00 22.94 ? 90 PHE B C 1 ATOM 3675 O O . PHE B 1 106 ? -23.678 -22.664 -6.539 1.00 27.66 ? 90 PHE B O 1 ATOM 3676 C CB . PHE B 1 106 ? -21.108 -22.533 -8.235 1.00 24.28 ? 90 PHE B CB 1 ATOM 3677 C CG . PHE B 1 106 ? -19.673 -22.384 -8.620 1.00 20.88 ? 90 PHE B CG 1 ATOM 3678 C CD1 . PHE B 1 106 ? -19.159 -21.152 -8.977 1.00 26.90 ? 90 PHE B CD1 1 ATOM 3679 C CD2 . PHE B 1 106 ? -18.839 -23.479 -8.631 1.00 31.33 ? 90 PHE B CD2 1 ATOM 3680 C CE1 . PHE B 1 106 ? -17.833 -21.013 -9.330 1.00 28.46 ? 90 PHE B CE1 1 ATOM 3681 C CE2 . PHE B 1 106 ? -17.515 -23.353 -8.981 1.00 35.35 ? 90 PHE B CE2 1 ATOM 3682 C CZ . PHE B 1 106 ? -17.008 -22.119 -9.332 1.00 26.62 ? 90 PHE B CZ 1 ATOM 3683 N N . VAL B 1 107 ? -23.489 -20.504 -7.155 1.00 25.64 ? 91 VAL B N 1 ATOM 3684 C CA . VAL B 1 107 ? -24.920 -20.286 -7.300 1.00 23.76 ? 91 VAL B CA 1 ATOM 3685 C C . VAL B 1 107 ? -25.240 -20.280 -8.789 1.00 21.43 ? 91 VAL B C 1 ATOM 3686 O O . VAL B 1 107 ? -24.714 -19.463 -9.542 1.00 25.89 ? 91 VAL B O 1 ATOM 3687 C CB . VAL B 1 107 ? -25.383 -18.961 -6.648 1.00 18.63 ? 91 VAL B CB 1 ATOM 3688 C CG1 . VAL B 1 107 ? -24.442 -17.806 -6.990 1.00 19.94 ? 91 VAL B CG1 1 ATOM 3689 C CG2 . VAL B 1 107 ? -26.809 -18.631 -7.066 1.00 24.77 ? 91 VAL B CG2 1 ATOM 3690 N N . CYS B 1 108 ? -26.083 -21.213 -9.215 1.00 21.32 ? 92 CYS B N 1 ATOM 3691 C CA . CYS B 1 108 ? -26.372 -21.373 -10.634 1.00 15.79 ? 92 CYS B CA 1 ATOM 3692 C C . CYS B 1 108 ? -27.800 -20.974 -10.981 1.00 16.91 ? 92 CYS B C 1 ATOM 3693 O O . CYS B 1 108 ? -28.674 -20.925 -10.116 1.00 21.20 ? 92 CYS B O 1 ATOM 3694 C CB . CYS B 1 108 ? -26.125 -22.820 -11.060 1.00 18.91 ? 92 CYS B CB 1 ATOM 3695 S SG . CYS B 1 108 ? -24.442 -23.401 -10.755 1.00 21.04 ? 92 CYS B SG 1 ATOM 3696 N N . ARG B 1 109 ? -28.025 -20.686 -12.258 1.00 15.81 ? 93 ARG B N 1 ATOM 3697 C CA . ARG B 1 109 ? -29.363 -20.399 -12.751 1.00 16.62 ? 93 ARG B CA 1 ATOM 3698 C C . ARG B 1 109 ? -29.477 -20.803 -14.212 1.00 17.01 ? 93 ARG B C 1 ATOM 3699 O O . ARG B 1 109 ? -28.677 -20.383 -15.048 1.00 18.55 ? 93 ARG B O 1 ATOM 3700 C CB . ARG B 1 109 ? -29.697 -18.916 -12.586 1.00 19.83 ? 93 ARG B CB 1 ATOM 3701 C CG . ARG B 1 109 ? -31.135 -18.574 -12.947 1.00 17.70 ? 93 ARG B CG 1 ATOM 3702 C CD . ARG B 1 109 ? -31.567 -17.253 -12.337 1.00 24.86 ? 93 ARG B CD 1 ATOM 3703 N NE . ARG B 1 109 ? -31.519 -17.287 -10.879 1.00 35.78 ? 93 ARG B NE 1 ATOM 3704 C CZ . ARG B 1 109 ? -31.872 -16.276 -10.091 1.00 29.74 ? 93 ARG B CZ 1 ATOM 3705 N NH1 . ARG B 1 109 ? -32.304 -15.136 -10.615 1.00 29.01 ? 93 ARG B NH1 1 ATOM 3706 N NH2 . ARG B 1 109 ? -31.793 -16.404 -8.775 1.00 30.48 ? 93 ARG B NH2 1 ATOM 3707 N N . ARG B 1 110 ? -30.479 -21.622 -14.510 1.00 19.83 ? 94 ARG B N 1 ATOM 3708 C CA . ARG B 1 110 ? -30.686 -22.123 -15.861 1.00 23.34 ? 94 ARG B CA 1 ATOM 3709 C C . ARG B 1 110 ? -31.811 -21.347 -16.535 1.00 22.53 ? 94 ARG B C 1 ATOM 3710 O O . ARG B 1 110 ? -32.670 -20.774 -15.863 1.00 18.30 ? 94 ARG B O 1 ATOM 3711 C CB . ARG B 1 110 ? -31.012 -23.616 -15.819 1.00 19.88 ? 94 ARG B CB 1 ATOM 3712 C CG . ARG B 1 110 ? -30.946 -24.314 -17.166 1.00 24.41 ? 94 ARG B CG 1 ATOM 3713 C CD . ARG B 1 110 ? -31.030 -25.825 -16.999 1.00 28.23 ? 94 ARG B CD 1 ATOM 3714 N NE . ARG B 1 110 ? -29.708 -26.435 -16.859 1.00 21.40 ? 94 ARG B NE 1 ATOM 3715 C CZ . ARG B 1 110 ? -29.357 -27.300 -15.909 1.00 23.57 ? 94 ARG B CZ 1 ATOM 3716 N NH1 . ARG B 1 110 ? -30.217 -27.689 -14.975 1.00 25.69 ? 94 ARG B NH1 1 ATOM 3717 N NH2 . ARG B 1 110 ? -28.125 -27.786 -15.887 1.00 26.94 ? 94 ARG B NH2 1 ATOM 3718 N N . THR B 1 111 ? -31.798 -21.324 -17.864 1.00 22.64 ? 95 THR B N 1 ATOM 3719 C CA . THR B 1 111 ? -32.794 -20.578 -18.624 1.00 24.67 ? 95 THR B CA 1 ATOM 3720 C C . THR B 1 111 ? -32.679 -20.868 -20.116 1.00 21.55 ? 95 THR B C 1 ATOM 3721 O O . THR B 1 111 ? -31.796 -21.608 -20.549 1.00 29.98 ? 95 THR B O 1 ATOM 3722 C CB . THR B 1 111 ? -32.637 -19.061 -18.407 1.00 21.59 ? 95 THR B CB 1 ATOM 3723 O OG1 . THR B 1 111 ? -33.590 -18.357 -19.212 1.00 27.45 ? 95 THR B OG1 1 ATOM 3724 C CG2 . THR B 1 111 ? -31.233 -18.610 -18.778 1.00 21.92 ? 95 THR B CG2 1 ATOM 3725 N N . PHE B 1 112 ? -33.578 -20.276 -20.895 1.00 23.70 ? 96 PHE B N 1 ATOM 3726 C CA . PHE B 1 112 ? -33.544 -20.403 -22.348 1.00 22.23 ? 96 PHE B CA 1 ATOM 3727 C C . PHE B 1 112 ? -33.325 -19.047 -23.005 1.00 18.43 ? 96 PHE B C 1 ATOM 3728 O O . PHE B 1 112 ? -33.971 -18.061 -22.651 1.00 21.97 ? 96 PHE B O 1 ATOM 3729 C CB . PHE B 1 112 ? -34.840 -21.032 -22.869 1.00 25.19 ? 96 PHE B CB 1 ATOM 3730 C CG . PHE B 1 112 ? -34.776 -22.528 -22.997 1.00 29.98 ? 96 PHE B CG 1 ATOM 3731 C CD1 . PHE B 1 112 ? -34.027 -23.115 -24.003 1.00 28.50 ? 96 PHE B CD1 1 ATOM 3732 C CD2 . PHE B 1 112 ? -35.468 -23.347 -22.119 1.00 31.99 ? 96 PHE B CD2 1 ATOM 3733 C CE1 . PHE B 1 112 ? -33.961 -24.489 -24.128 1.00 29.64 ? 96 PHE B CE1 1 ATOM 3734 C CE2 . PHE B 1 112 ? -35.406 -24.724 -22.240 1.00 35.83 ? 96 PHE B CE2 1 ATOM 3735 C CZ . PHE B 1 112 ? -34.652 -25.294 -23.246 1.00 35.37 ? 96 PHE B CZ 1 ATOM 3736 N N . VAL B 1 113 ? -32.406 -19.009 -23.965 1.00 25.31 ? 97 VAL B N 1 ATOM 3737 C CA . VAL B 1 113 ? -32.099 -17.783 -24.691 1.00 26.43 ? 97 VAL B CA 1 ATOM 3738 C C . VAL B 1 113 ? -32.470 -17.932 -26.159 1.00 20.70 ? 97 VAL B C 1 ATOM 3739 O O . VAL B 1 113 ? -32.712 -19.037 -26.640 1.00 16.85 ? 97 VAL B O 1 ATOM 3740 C CB . VAL B 1 113 ? -30.603 -17.417 -24.594 1.00 24.42 ? 97 VAL B CB 1 ATOM 3741 C CG1 . VAL B 1 113 ? -30.261 -16.934 -23.191 1.00 21.79 ? 97 VAL B CG1 1 ATOM 3742 C CG2 . VAL B 1 113 ? -29.731 -18.600 -24.995 1.00 17.44 ? 97 VAL B CG2 1 ATOM 3743 N N . ASP B 1 114 ? -32.519 -16.809 -26.864 1.00 17.71 ? 98 ASP B N 1 ATOM 3744 C CA . ASP B 1 114 ? -32.831 -16.816 -28.285 1.00 23.93 ? 98 ASP B CA 1 ATOM 3745 C C . ASP B 1 114 ? -31.599 -17.080 -29.138 1.00 25.49 ? 98 ASP B C 1 ATOM 3746 O O . ASP B 1 114 ? -30.699 -16.245 -29.226 1.00 24.53 ? 98 ASP B O 1 ATOM 3747 C CB . ASP B 1 114 ? -33.459 -15.486 -28.697 1.00 30.01 ? 98 ASP B CB 1 ATOM 3748 C CG . ASP B 1 114 ? -34.931 -15.409 -28.353 1.00 38.26 ? 98 ASP B CG 1 ATOM 3749 O OD1 . ASP B 1 114 ? -35.671 -16.355 -28.699 1.00 28.35 ? 98 ASP B OD1 1 ATOM 3750 O OD2 . ASP B 1 114 ? -35.349 -14.408 -27.730 1.00 41.97 ? 98 ASP B OD2 1 ATOM 3751 N N . ARG B 1 115 ? -31.568 -18.252 -29.762 1.00 22.99 ? 99 ARG B N 1 ATOM 3752 C CA . ARG B 1 115 ? -30.607 -18.528 -30.818 1.00 24.17 ? 99 ARG B CA 1 ATOM 3753 C C . ARG B 1 115 ? -31.380 -18.474 -32.126 1.00 25.99 ? 99 ARG B C 1 ATOM 3754 O O . ARG B 1 115 ? -31.041 -19.148 -33.096 1.00 30.98 ? 99 ARG B O 1 ATOM 3755 C CB . ARG B 1 115 ? -29.963 -19.903 -30.634 1.00 26.48 ? 99 ARG B CB 1 ATOM 3756 C CG . ARG B 1 115 ? -29.643 -20.262 -29.188 1.00 18.40 ? 99 ARG B CG 1 ATOM 3757 C CD . ARG B 1 115 ? -28.659 -19.288 -28.559 1.00 19.22 ? 99 ARG B CD 1 ATOM 3758 N NE . ARG B 1 115 ? -27.340 -19.347 -29.186 1.00 25.40 ? 99 ARG B NE 1 ATOM 3759 C CZ . ARG B 1 115 ? -26.402 -20.244 -28.892 1.00 20.10 ? 99 ARG B CZ 1 ATOM 3760 N NH1 . ARG B 1 115 ? -26.624 -21.183 -27.980 1.00 26.21 ? 99 ARG B NH1 1 ATOM 3761 N NH2 . ARG B 1 115 ? -25.235 -20.207 -29.516 1.00 20.69 ? 99 ARG B NH2 1 ATOM 3762 N N . GLY B 1 116 ? -32.433 -17.662 -32.131 1.00 30.56 ? 100 GLY B N 1 ATOM 3763 C CA . GLY B 1 116 ? -33.356 -17.594 -33.247 1.00 36.43 ? 100 GLY B CA 1 ATOM 3764 C C . GLY B 1 116 ? -32.672 -17.511 -34.596 1.00 41.64 ? 100 GLY B C 1 ATOM 3765 O O . GLY B 1 116 ? -33.237 -16.990 -35.558 1.00 43.56 ? 100 GLY B O 1 ATOM 3766 N N . GLY B 1 118 ? -27.308 -18.809 -36.575 1.00 29.05 ? 102 GLY B N 1 ATOM 3767 C CA . GLY B 1 118 ? -27.740 -18.120 -35.373 1.00 35.14 ? 102 GLY B CA 1 ATOM 3768 C C . GLY B 1 118 ? -26.665 -18.118 -34.303 1.00 41.01 ? 102 GLY B C 1 ATOM 3769 O O . GLY B 1 118 ? -26.645 -18.990 -33.435 1.00 40.86 ? 102 GLY B O 1 ATOM 3770 N N . ASN B 1 119 ? -25.768 -17.138 -34.375 1.00 47.81 ? 103 ASN B N 1 ATOM 3771 C CA . ASN B 1 119 ? -24.668 -17.002 -33.421 1.00 36.46 ? 103 ASN B CA 1 ATOM 3772 C C . ASN B 1 119 ? -24.196 -18.332 -32.832 1.00 25.73 ? 103 ASN B C 1 ATOM 3773 O O . ASN B 1 119 ? -24.143 -18.496 -31.613 1.00 23.40 ? 103 ASN B O 1 ATOM 3774 C CB . ASN B 1 119 ? -25.056 -16.031 -32.298 1.00 33.95 ? 103 ASN B CB 1 ATOM 3775 C CG . ASN B 1 119 ? -26.337 -16.434 -31.586 1.00 26.93 ? 103 ASN B CG 1 ATOM 3776 O OD1 . ASN B 1 119 ? -26.582 -17.614 -31.341 1.00 30.81 ? 103 ASN B OD1 1 ATOM 3777 N ND2 . ASN B 1 119 ? -27.161 -15.448 -31.250 1.00 21.57 ? 103 ASN B ND2 1 ATOM 3778 N N . GLY B 1 120 ? -23.848 -19.274 -33.704 1.00 22.43 ? 104 GLY B N 1 ATOM 3779 C CA . GLY B 1 120 ? -23.375 -20.578 -33.274 1.00 21.43 ? 104 GLY B CA 1 ATOM 3780 C C . GLY B 1 120 ? -24.395 -21.673 -33.514 1.00 26.80 ? 104 GLY B C 1 ATOM 3781 O O . GLY B 1 120 ? -24.135 -22.843 -33.234 1.00 34.39 ? 104 GLY B O 1 ATOM 3782 N N . CYS B 1 121 ? -25.555 -21.293 -34.041 1.00 28.39 ? 105 CYS B N 1 ATOM 3783 C CA . CYS B 1 121 ? -26.652 -22.227 -34.239 1.00 24.15 ? 105 CYS B CA 1 ATOM 3784 C C . CYS B 1 121 ? -27.204 -22.092 -35.647 1.00 18.76 ? 105 CYS B C 1 ATOM 3785 O O . CYS B 1 121 ? -27.591 -21.004 -36.074 1.00 24.09 ? 105 CYS B O 1 ATOM 3786 C CB . CYS B 1 121 ? -27.766 -21.970 -33.227 1.00 24.68 ? 105 CYS B CB 1 ATOM 3787 S SG . CYS B 1 121 ? -27.231 -21.986 -31.511 1.00 22.98 ? 105 CYS B SG 1 ATOM 3788 N N . GLY B 1 122 ? -27.229 -23.209 -36.362 1.00 15.48 ? 106 GLY B N 1 ATOM 3789 C CA . GLY B 1 122 ? -27.775 -23.257 -37.703 1.00 17.93 ? 106 GLY B CA 1 ATOM 3790 C C . GLY B 1 122 ? -29.291 -23.349 -37.739 1.00 24.90 ? 106 GLY B C 1 ATOM 3791 O O . GLY B 1 122 ? -29.900 -23.164 -38.794 1.00 30.30 ? 106 GLY B O 1 ATOM 3792 N N . LEU B 1 123 ? -29.901 -23.645 -36.593 1.00 24.62 ? 107 LEU B N 1 ATOM 3793 C CA . LEU B 1 123 ? -31.358 -23.675 -36.481 1.00 14.35 ? 107 LEU B CA 1 ATOM 3794 C C . LEU B 1 123 ? -31.847 -22.449 -35.716 1.00 18.94 ? 107 LEU B C 1 ATOM 3795 O O . LEU B 1 123 ? -31.112 -21.875 -34.912 1.00 20.44 ? 107 LEU B O 1 ATOM 3796 C CB . LEU B 1 123 ? -31.827 -24.952 -35.779 1.00 23.24 ? 107 LEU B CB 1 ATOM 3797 C CG . LEU B 1 123 ? -31.509 -26.274 -36.479 1.00 22.04 ? 107 LEU B CG 1 ATOM 3798 C CD1 . LEU B 1 123 ? -32.193 -27.429 -35.762 1.00 20.73 ? 107 LEU B CD1 1 ATOM 3799 C CD2 . LEU B 1 123 ? -31.923 -26.229 -37.942 1.00 14.49 ? 107 LEU B CD2 1 ATOM 3800 N N . PHE B 1 124 ? -33.091 -22.056 -35.971 1.00 21.23 ? 108 PHE B N 1 ATOM 3801 C CA . PHE B 1 124 ? -33.659 -20.859 -35.365 1.00 24.57 ? 108 PHE B CA 1 ATOM 3802 C C . PHE B 1 124 ? -34.671 -21.223 -34.278 1.00 27.96 ? 108 PHE B C 1 ATOM 3803 O O . PHE B 1 124 ? -35.725 -21.793 -34.558 1.00 35.77 ? 108 PHE B O 1 ATOM 3804 C CB . PHE B 1 124 ? -34.296 -19.979 -36.449 1.00 28.75 ? 108 PHE B CB 1 ATOM 3805 C CG . PHE B 1 124 ? -35.742 -19.639 -36.197 1.00 36.24 ? 108 PHE B CG 1 ATOM 3806 C CD1 . PHE B 1 124 ? -36.104 -18.819 -35.140 1.00 33.50 ? 108 PHE B CD1 1 ATOM 3807 C CD2 . PHE B 1 124 ? -36.738 -20.130 -37.027 1.00 44.73 ? 108 PHE B CD2 1 ATOM 3808 C CE1 . PHE B 1 124 ? -37.429 -18.506 -34.909 1.00 37.98 ? 108 PHE B CE1 1 ATOM 3809 C CE2 . PHE B 1 124 ? -38.065 -19.816 -36.802 1.00 40.51 ? 108 PHE B CE2 1 ATOM 3810 C CZ . PHE B 1 124 ? -38.410 -19.003 -35.742 1.00 33.39 ? 108 PHE B CZ 1 ATOM 3811 N N . GLY B 1 125 ? -34.332 -20.899 -33.033 1.00 19.73 ? 109 GLY B N 1 ATOM 3812 C CA . GLY B 1 125 ? -35.196 -21.181 -31.899 1.00 19.00 ? 109 GLY B CA 1 ATOM 3813 C C . GLY B 1 125 ? -34.546 -20.820 -30.574 1.00 21.36 ? 109 GLY B C 1 ATOM 3814 O O . GLY B 1 125 ? -33.657 -19.971 -30.518 1.00 25.10 ? 109 GLY B O 1 ATOM 3815 N N . LYS B 1 126 ? -34.995 -21.471 -29.504 1.00 17.52 ? 110 LYS B N 1 ATOM 3816 C CA . LYS B 1 126 ? -34.459 -21.232 -28.167 1.00 18.94 ? 110 LYS B CA 1 ATOM 3817 C C . LYS B 1 126 ? -33.344 -22.219 -27.841 1.00 19.18 ? 110 LYS B C 1 ATOM 3818 O O . LYS B 1 126 ? -33.447 -23.408 -28.142 1.00 16.56 ? 110 LYS B O 1 ATOM 3819 C CB . LYS B 1 126 ? -35.567 -21.352 -27.116 1.00 20.75 ? 110 LYS B CB 1 ATOM 3820 C CG . LYS B 1 126 ? -36.094 -20.023 -26.590 1.00 19.35 ? 110 LYS B CG 1 ATOM 3821 C CD . LYS B 1 126 ? -37.065 -19.371 -27.555 1.00 23.27 ? 110 LYS B CD 1 ATOM 3822 C CE . LYS B 1 126 ? -37.884 -18.290 -26.862 1.00 26.63 ? 110 LYS B CE 1 ATOM 3823 N NZ . LYS B 1 126 ? -37.037 -17.223 -26.261 1.00 26.69 ? 110 LYS B NZ 1 ATOM 3824 N N . GLY B 1 127 ? -32.280 -21.718 -27.220 1.00 20.79 ? 111 GLY B N 1 ATOM 3825 C CA . GLY B 1 127 ? -31.158 -22.549 -26.821 1.00 22.47 ? 111 GLY B CA 1 ATOM 3826 C C . GLY B 1 127 ? -30.997 -22.593 -25.313 1.00 23.59 ? 111 GLY B C 1 ATOM 3827 O O . GLY B 1 127 ? -31.206 -21.591 -24.628 1.00 23.29 ? 111 GLY B O 1 ATOM 3828 N N . SER B 1 128 ? -30.626 -23.759 -24.794 1.00 20.94 ? 112 SER B N 1 ATOM 3829 C CA . SER B 1 128 ? -30.458 -23.945 -23.357 1.00 22.25 ? 112 SER B CA 1 ATOM 3830 C C . SER B 1 128 ? -29.199 -23.248 -22.856 1.00 22.20 ? 112 SER B C 1 ATOM 3831 O O . SER B 1 128 ? -28.128 -23.383 -23.446 1.00 28.89 ? 112 SER B O 1 ATOM 3832 C CB . SER B 1 128 ? -30.396 -25.437 -23.022 1.00 24.07 ? 112 SER B CB 1 ATOM 3833 O OG . SER B 1 128 ? -30.178 -25.653 -21.638 1.00 33.39 ? 112 SER B OG 1 ATOM 3834 N N . LEU B 1 129 ? -29.337 -22.510 -21.760 1.00 21.30 ? 113 LEU B N 1 ATOM 3835 C CA . LEU B 1 129 ? -28.218 -21.789 -21.168 1.00 22.59 ? 113 LEU B CA 1 ATOM 3836 C C . LEU B 1 129 ? -28.226 -21.940 -19.652 1.00 17.74 ? 113 LEU B C 1 ATOM 3837 O O . LEU B 1 129 ? -29.285 -22.069 -19.038 1.00 21.00 ? 113 LEU B O 1 ATOM 3838 C CB . LEU B 1 129 ? -28.280 -20.306 -21.547 1.00 24.31 ? 113 LEU B CB 1 ATOM 3839 C CG . LEU B 1 129 ? -27.204 -19.403 -20.939 1.00 21.86 ? 113 LEU B CG 1 ATOM 3840 C CD1 . LEU B 1 129 ? -26.784 -18.333 -21.934 1.00 21.86 ? 113 LEU B CD1 1 ATOM 3841 C CD2 . LEU B 1 129 ? -27.698 -18.761 -19.649 1.00 21.81 ? 113 LEU B CD2 1 ATOM 3842 N N . ILE B 1 130 ? -27.037 -21.927 -19.057 1.00 17.48 ? 114 ILE B N 1 ATOM 3843 C CA . ILE B 1 130 ? -26.898 -21.992 -17.607 1.00 17.02 ? 114 ILE B CA 1 ATOM 3844 C C . ILE B 1 130 ? -25.675 -21.206 -17.149 1.00 11.43 ? 114 ILE B C 1 ATOM 3845 O O . ILE B 1 130 ? -24.652 -21.176 -17.833 1.00 18.45 ? 114 ILE B O 1 ATOM 3846 C CB . ILE B 1 130 ? -26.772 -23.443 -17.107 1.00 22.41 ? 114 ILE B CB 1 ATOM 3847 C CG1 . ILE B 1 130 ? -26.580 -23.461 -15.590 1.00 14.46 ? 114 ILE B CG1 1 ATOM 3848 C CG2 . ILE B 1 130 ? -25.608 -24.145 -17.793 1.00 24.95 ? 114 ILE B CG2 1 ATOM 3849 C CD1 . ILE B 1 130 ? -26.812 -24.813 -14.961 1.00 14.59 ? 114 ILE B CD1 1 ATOM 3850 N N . THR B 1 131 ? -25.791 -20.574 -15.986 1.00 9.90 ? 115 THR B N 1 ATOM 3851 C CA . THR B 1 131 ? -24.720 -19.753 -15.437 1.00 16.03 ? 115 THR B CA 1 ATOM 3852 C C . THR B 1 131 ? -24.382 -20.210 -14.022 1.00 17.10 ? 115 THR B C 1 ATOM 3853 O O . THR B 1 131 ? -25.230 -20.759 -13.322 1.00 18.13 ? 115 THR B O 1 ATOM 3854 C CB . THR B 1 131 ? -25.128 -18.268 -15.392 1.00 20.25 ? 115 THR B CB 1 ATOM 3855 O OG1 . THR B 1 131 ? -25.607 -17.858 -16.679 1.00 21.10 ? 115 THR B OG1 1 ATOM 3856 C CG2 . THR B 1 131 ? -23.948 -17.396 -14.994 1.00 15.73 ? 115 THR B CG2 1 ATOM 3857 N N . CYS B 1 132 ? -23.139 -19.984 -13.609 1.00 16.74 ? 116 CYS B N 1 ATOM 3858 C CA . CYS B 1 132 ? -22.696 -20.333 -12.264 1.00 17.54 ? 116 CYS B CA 1 ATOM 3859 C C . CYS B 1 132 ? -21.595 -19.381 -11.814 1.00 22.80 ? 116 CYS B C 1 ATOM 3860 O O . CYS B 1 132 ? -20.642 -19.128 -12.550 1.00 23.83 ? 116 CYS B O 1 ATOM 3861 C CB . CYS B 1 132 ? -22.188 -21.775 -12.222 1.00 13.65 ? 116 CYS B CB 1 ATOM 3862 S SG . CYS B 1 132 ? -23.467 -23.023 -12.496 1.00 18.77 ? 116 CYS B SG 1 ATOM 3863 N N . ALA B 1 133 ? -21.724 -18.866 -10.595 1.00 17.86 ? 117 ALA B N 1 ATOM 3864 C CA . ALA B 1 133 ? -20.778 -17.884 -10.076 1.00 20.70 ? 117 ALA B CA 1 ATOM 3865 C C . ALA B 1 133 ? -20.431 -18.180 -8.619 1.00 21.67 ? 117 ALA B C 1 ATOM 3866 O O . ALA B 1 133 ? -21.297 -18.564 -7.834 1.00 26.51 ? 117 ALA B O 1 ATOM 3867 C CB . ALA B 1 133 ? -21.351 -16.483 -10.213 1.00 28.27 ? 117 ALA B CB 1 ATOM 3868 N N . LYS B 1 134 ? -19.160 -18.008 -8.266 1.00 22.09 ? 118 LYS B N 1 ATOM 3869 C CA . LYS B 1 134 ? -18.680 -18.357 -6.930 1.00 23.79 ? 118 LYS B CA 1 ATOM 3870 C C . LYS B 1 134 ? -19.214 -17.414 -5.861 1.00 26.88 ? 118 LYS B C 1 ATOM 3871 O O . LYS B 1 134 ? -18.779 -16.268 -5.755 1.00 31.52 ? 118 LYS B O 1 ATOM 3872 C CB . LYS B 1 134 ? -17.148 -18.362 -6.884 1.00 26.40 ? 118 LYS B CB 1 ATOM 3873 C CG . LYS B 1 134 ? -16.587 -18.504 -5.474 1.00 30.50 ? 118 LYS B CG 1 ATOM 3874 C CD . LYS B 1 134 ? -15.139 -18.968 -5.474 1.00 42.36 ? 118 LYS B CD 1 ATOM 3875 C CE . LYS B 1 134 ? -14.297 -18.171 -6.454 1.00 54.62 ? 118 LYS B CE 1 ATOM 3876 N NZ . LYS B 1 134 ? -12.834 -18.348 -6.230 1.00 58.47 ? 118 LYS B NZ 1 ATOM 3877 N N . PHE B 1 135 ? -20.150 -17.914 -5.062 1.00 27.77 ? 119 PHE B N 1 ATOM 3878 C CA . PHE B 1 135 ? -20.702 -17.153 -3.951 1.00 28.18 ? 119 PHE B CA 1 ATOM 3879 C C . PHE B 1 135 ? -19.755 -17.197 -2.757 1.00 22.05 ? 119 PHE B C 1 ATOM 3880 O O . PHE B 1 135 ? -19.357 -18.272 -2.309 1.00 20.71 ? 119 PHE B O 1 ATOM 3881 C CB . PHE B 1 135 ? -22.067 -17.718 -3.556 1.00 28.16 ? 119 PHE B CB 1 ATOM 3882 C CG . PHE B 1 135 ? -22.732 -16.973 -2.434 1.00 17.47 ? 119 PHE B CG 1 ATOM 3883 C CD1 . PHE B 1 135 ? -23.494 -15.845 -2.690 1.00 17.78 ? 119 PHE B CD1 1 ATOM 3884 C CD2 . PHE B 1 135 ? -22.601 -17.404 -1.125 1.00 15.57 ? 119 PHE B CD2 1 ATOM 3885 C CE1 . PHE B 1 135 ? -24.108 -15.158 -1.660 1.00 18.39 ? 119 PHE B CE1 1 ATOM 3886 C CE2 . PHE B 1 135 ? -23.213 -16.721 -0.091 1.00 13.39 ? 119 PHE B CE2 1 ATOM 3887 C CZ . PHE B 1 135 ? -23.967 -15.597 -0.359 1.00 14.58 ? 119 PHE B CZ 1 ATOM 3888 N N . LYS B 1 136 ? -19.400 -16.022 -2.248 1.00 23.28 ? 120 LYS B N 1 ATOM 3889 C CA . LYS B 1 136 ? -18.502 -15.916 -1.104 1.00 22.62 ? 120 LYS B CA 1 ATOM 3890 C C . LYS B 1 136 ? -19.020 -14.877 -0.117 1.00 21.43 ? 120 LYS B C 1 ATOM 3891 O O . LYS B 1 136 ? -19.266 -13.731 -0.485 1.00 23.70 ? 120 LYS B O 1 ATOM 3892 C CB . LYS B 1 136 ? -17.093 -15.536 -1.567 1.00 19.92 ? 120 LYS B CB 1 ATOM 3893 C CG . LYS B 1 136 ? -16.133 -15.197 -0.436 1.00 17.73 ? 120 LYS B CG 1 ATOM 3894 C CD . LYS B 1 136 ? -16.009 -16.338 0.557 1.00 25.06 ? 120 LYS B CD 1 ATOM 3895 C CE . LYS B 1 136 ? -15.064 -15.987 1.697 1.00 32.86 ? 120 LYS B CE 1 ATOM 3896 N NZ . LYS B 1 136 ? -13.652 -15.845 1.244 1.00 37.60 ? 120 LYS B NZ 1 ATOM 3897 N N . CYS B 1 137 ? -19.190 -15.284 1.136 1.00 20.58 ? 121 CYS B N 1 ATOM 3898 C CA . CYS B 1 137 ? -19.672 -14.378 2.170 1.00 17.32 ? 121 CYS B CA 1 ATOM 3899 C C . CYS B 1 137 ? -18.514 -13.617 2.806 1.00 21.09 ? 121 CYS B C 1 ATOM 3900 O O . CYS B 1 137 ? -17.707 -14.191 3.537 1.00 16.79 ? 121 CYS B O 1 ATOM 3901 C CB . CYS B 1 137 ? -20.438 -15.153 3.241 1.00 18.67 ? 121 CYS B CB 1 ATOM 3902 S SG . CYS B 1 137 ? -21.333 -14.107 4.411 1.00 16.70 ? 121 CYS B SG 1 ATOM 3903 N N . VAL B 1 138 ? -18.445 -12.319 2.529 1.00 22.35 ? 122 VAL B N 1 ATOM 3904 C CA . VAL B 1 138 ? -17.388 -11.477 3.071 1.00 22.13 ? 122 VAL B CA 1 ATOM 3905 C C . VAL B 1 138 ? -17.631 -11.228 4.551 1.00 24.44 ? 122 VAL B C 1 ATOM 3906 O O . VAL B 1 138 ? -16.743 -11.420 5.381 1.00 32.42 ? 122 VAL B O 1 ATOM 3907 C CB . VAL B 1 138 ? -17.327 -10.112 2.357 1.00 21.78 ? 122 VAL B CB 1 ATOM 3908 C CG1 . VAL B 1 138 ? -16.183 -9.273 2.913 1.00 30.41 ? 122 VAL B CG1 1 ATOM 3909 C CG2 . VAL B 1 138 ? -17.174 -10.289 0.856 1.00 19.46 ? 122 VAL B CG2 1 ATOM 3910 N N . THR B 1 139 ? -18.846 -10.801 4.875 1.00 19.29 ? 123 THR B N 1 ATOM 3911 C CA . THR B 1 139 ? -19.202 -10.471 6.248 1.00 22.66 ? 123 THR B CA 1 ATOM 3912 C C . THR B 1 139 ? -20.457 -11.224 6.674 1.00 23.50 ? 123 THR B C 1 ATOM 3913 O O . THR B 1 139 ? -21.453 -11.246 5.951 1.00 24.16 ? 123 THR B O 1 ATOM 3914 C CB . THR B 1 139 ? -19.444 -8.959 6.411 1.00 28.67 ? 123 THR B CB 1 ATOM 3915 O OG1 . THR B 1 139 ? -18.332 -8.234 5.870 1.00 37.28 ? 123 THR B OG1 1 ATOM 3916 C CG2 . THR B 1 139 ? -19.624 -8.594 7.881 1.00 22.01 ? 123 THR B CG2 1 ATOM 3917 N N . LYS B 1 140 ? -20.400 -11.836 7.854 1.00 21.30 ? 124 LYS B N 1 ATOM 3918 C CA . LYS B 1 140 ? -21.522 -12.607 8.374 1.00 19.26 ? 124 LYS B CA 1 ATOM 3919 C C . LYS B 1 140 ? -21.894 -12.171 9.784 1.00 14.96 ? 124 LYS B C 1 ATOM 3920 O O . LYS B 1 140 ? -21.059 -11.656 10.528 1.00 20.07 ? 124 LYS B O 1 ATOM 3921 C CB . LYS B 1 140 ? -21.197 -14.106 8.378 1.00 19.91 ? 124 LYS B CB 1 ATOM 3922 C CG . LYS B 1 140 ? -19.724 -14.442 8.557 1.00 32.19 ? 124 LYS B CG 1 ATOM 3923 C CD . LYS B 1 140 ? -19.050 -14.672 7.215 1.00 33.73 ? 124 LYS B CD 1 ATOM 3924 C CE . LYS B 1 140 ? -17.539 -14.717 7.341 1.00 30.06 ? 124 LYS B CE 1 ATOM 3925 N NZ . LYS B 1 140 ? -16.894 -14.961 6.022 1.00 23.79 ? 124 LYS B NZ 1 ATOM 3926 N N . LEU B 1 141 ? -23.158 -12.376 10.141 1.00 11.28 ? 125 LEU B N 1 ATOM 3927 C CA . LEU B 1 141 ? -23.598 -12.205 11.518 1.00 17.34 ? 125 LEU B CA 1 ATOM 3928 C C . LEU B 1 141 ? -24.064 -13.556 12.046 1.00 13.60 ? 125 LEU B C 1 ATOM 3929 O O . LEU B 1 141 ? -24.588 -14.377 11.292 1.00 18.26 ? 125 LEU B O 1 ATOM 3930 C CB . LEU B 1 141 ? -24.709 -11.152 11.619 1.00 16.97 ? 125 LEU B CB 1 ATOM 3931 C CG . LEU B 1 141 ? -26.109 -11.471 11.084 1.00 15.07 ? 125 LEU B CG 1 ATOM 3932 C CD1 . LEU B 1 141 ? -26.897 -12.391 12.010 1.00 14.96 ? 125 LEU B CD1 1 ATOM 3933 C CD2 . LEU B 1 141 ? -26.879 -10.177 10.874 1.00 12.74 ? 125 LEU B CD2 1 ATOM 3934 N N . GLU B 1 142 ? -23.858 -13.789 13.337 1.00 16.94 ? 126 GLU B N 1 ATOM 3935 C CA . GLU B 1 142 ? -24.211 -15.064 13.946 1.00 8.15 ? 126 GLU B CA 1 ATOM 3936 C C . GLU B 1 142 ? -25.313 -14.891 14.984 1.00 7.73 ? 126 GLU B C 1 ATOM 3937 O O . GLU B 1 142 ? -25.382 -13.869 15.666 1.00 9.94 ? 126 GLU B O 1 ATOM 3938 C CB . GLU B 1 142 ? -22.976 -15.695 14.591 1.00 17.13 ? 126 GLU B CB 1 ATOM 3939 C CG . GLU B 1 142 ? -21.920 -16.140 13.589 1.00 21.28 ? 126 GLU B CG 1 ATOM 3940 C CD . GLU B 1 142 ? -20.646 -16.621 14.257 1.00 26.44 ? 126 GLU B CD 1 ATOM 3941 O OE1 . GLU B 1 142 ? -20.504 -16.419 15.481 1.00 25.14 ? 126 GLU B OE1 1 ATOM 3942 O OE2 . GLU B 1 142 ? -19.791 -17.205 13.558 1.00 37.20 ? 126 GLU B OE2 1 ATOM 3943 N N . GLY B 1 143 ? -26.177 -15.896 15.094 1.00 9.83 ? 127 GLY B N 1 ATOM 3944 C CA . GLY B 1 143 ? -27.244 -15.889 16.077 1.00 7.38 ? 127 GLY B CA 1 ATOM 3945 C C . GLY B 1 143 ? -27.071 -17.037 17.051 1.00 3.93 ? 127 GLY B C 1 ATOM 3946 O O . GLY B 1 143 ? -27.192 -18.200 16.673 1.00 5.33 ? 127 GLY B O 1 ATOM 3947 N N . LYS B 1 144 ? -26.791 -16.712 18.308 1.00 5.36 ? 128 LYS B N 1 ATOM 3948 C CA . LYS B 1 144 ? -26.443 -17.725 19.296 1.00 5.62 ? 128 LYS B CA 1 ATOM 3949 C C . LYS B 1 144 ? -27.528 -17.907 20.354 1.00 7.96 ? 128 LYS B C 1 ATOM 3950 O O . LYS B 1 144 ? -28.187 -16.948 20.753 1.00 6.97 ? 128 LYS B O 1 ATOM 3951 C CB . LYS B 1 144 ? -25.121 -17.351 19.964 1.00 6.05 ? 128 LYS B CB 1 ATOM 3952 C CG . LYS B 1 144 ? -23.973 -17.182 18.982 1.00 6.48 ? 128 LYS B CG 1 ATOM 3953 C CD . LYS B 1 144 ? -22.701 -16.745 19.684 1.00 8.30 ? 128 LYS B CD 1 ATOM 3954 C CE . LYS B 1 144 ? -21.514 -16.730 18.732 1.00 12.60 ? 128 LYS B CE 1 ATOM 3955 N NZ . LYS B 1 144 ? -20.215 -16.872 19.447 1.00 20.99 ? 128 LYS B NZ 1 ATOM 3956 N N . ILE B 1 145 ? -27.702 -19.144 20.808 1.00 7.01 ? 129 ILE B N 1 ATOM 3957 C CA . ILE B 1 145 ? -28.668 -19.441 21.860 1.00 7.92 ? 129 ILE B CA 1 ATOM 3958 C C . ILE B 1 145 ? -27.972 -19.605 23.206 1.00 6.35 ? 129 ILE B C 1 ATOM 3959 O O . ILE B 1 145 ? -26.832 -20.062 23.278 1.00 4.73 ? 129 ILE B O 1 ATOM 3960 C CB . ILE B 1 145 ? -29.471 -20.722 21.559 1.00 10.18 ? 129 ILE B CB 1 ATOM 3961 C CG1 . ILE B 1 145 ? -28.527 -21.865 21.185 1.00 5.25 ? 129 ILE B CG1 1 ATOM 3962 C CG2 . ILE B 1 145 ? -30.470 -20.469 20.439 1.00 8.77 ? 129 ILE B CG2 1 ATOM 3963 C CD1 . ILE B 1 145 ? -29.051 -23.226 21.541 1.00 8.19 ? 129 ILE B CD1 1 ATOM 3964 N N . VAL B 1 146 ? -28.671 -19.228 24.272 1.00 7.59 ? 130 VAL B N 1 ATOM 3965 C CA . VAL B 1 146 ? -28.141 -19.364 25.623 1.00 3.51 ? 130 VAL B CA 1 ATOM 3966 C C . VAL B 1 146 ? -28.848 -20.494 26.360 1.00 2.60 ? 130 VAL B C 1 ATOM 3967 O O . VAL B 1 146 ? -30.053 -20.434 26.597 1.00 3.70 ? 130 VAL B O 1 ATOM 3968 C CB . VAL B 1 146 ? -28.307 -18.062 26.427 1.00 4.15 ? 130 VAL B CB 1 ATOM 3969 C CG1 . VAL B 1 146 ? -27.712 -18.219 27.820 1.00 2.93 ? 130 VAL B CG1 1 ATOM 3970 C CG2 . VAL B 1 146 ? -27.658 -16.900 25.691 1.00 2.01 ? 130 VAL B CG2 1 ATOM 3971 N N . GLN B 1 147 ? -28.087 -21.524 26.714 1.00 4.96 ? 131 GLN B N 1 ATOM 3972 C CA . GLN B 1 147 ? -28.625 -22.663 27.443 1.00 3.69 ? 131 GLN B CA 1 ATOM 3973 C C . GLN B 1 147 ? -28.198 -22.598 28.905 1.00 3.83 ? 131 GLN B C 1 ATOM 3974 O O . GLN B 1 147 ? -27.491 -21.678 29.313 1.00 4.51 ? 131 GLN B O 1 ATOM 3975 C CB . GLN B 1 147 ? -28.137 -23.970 26.813 1.00 5.07 ? 131 GLN B CB 1 ATOM 3976 C CG . GLN B 1 147 ? -28.398 -24.077 25.316 1.00 4.25 ? 131 GLN B CG 1 ATOM 3977 C CD . GLN B 1 147 ? -27.707 -25.271 24.688 1.00 5.25 ? 131 GLN B CD 1 ATOM 3978 O OE1 . GLN B 1 147 ? -27.991 -26.418 25.034 1.00 9.51 ? 131 GLN B OE1 1 ATOM 3979 N NE2 . GLN B 1 147 ? -26.791 -25.007 23.763 1.00 6.52 ? 131 GLN B NE2 1 ATOM 3980 N N . TYR B 1 148 ? -28.636 -23.575 29.692 1.00 5.29 ? 132 TYR B N 1 ATOM 3981 C CA . TYR B 1 148 ? -28.257 -23.652 31.098 1.00 4.68 ? 132 TYR B CA 1 ATOM 3982 C C . TYR B 1 148 ? -26.743 -23.758 31.246 1.00 5.56 ? 132 TYR B C 1 ATOM 3983 O O . TYR B 1 148 ? -26.173 -23.295 32.234 1.00 7.89 ? 132 TYR B O 1 ATOM 3984 C CB . TYR B 1 148 ? -28.913 -24.867 31.759 1.00 4.69 ? 132 TYR B CB 1 ATOM 3985 C CG . TYR B 1 148 ? -30.419 -24.783 31.889 1.00 6.08 ? 132 TYR B CG 1 ATOM 3986 C CD1 . TYR B 1 148 ? -31.050 -23.590 32.223 1.00 13.73 ? 132 TYR B CD1 1 ATOM 3987 C CD2 . TYR B 1 148 ? -31.211 -25.903 31.681 1.00 6.63 ? 132 TYR B CD2 1 ATOM 3988 C CE1 . TYR B 1 148 ? -32.427 -23.519 32.343 1.00 6.83 ? 132 TYR B CE1 1 ATOM 3989 C CE2 . TYR B 1 148 ? -32.585 -25.841 31.795 1.00 6.48 ? 132 TYR B CE2 1 ATOM 3990 C CZ . TYR B 1 148 ? -33.188 -24.649 32.127 1.00 10.64 ? 132 TYR B CZ 1 ATOM 3991 O OH . TYR B 1 148 ? -34.556 -24.589 32.244 1.00 22.07 ? 132 TYR B OH 1 ATOM 3992 N N . GLU B 1 149 ? -26.097 -24.364 30.255 1.00 5.96 ? 133 GLU B N 1 ATOM 3993 C CA . GLU B 1 149 ? -24.675 -24.674 30.343 1.00 4.31 ? 133 GLU B CA 1 ATOM 3994 C C . GLU B 1 149 ? -23.782 -23.487 29.972 1.00 5.02 ? 133 GLU B C 1 ATOM 3995 O O . GLU B 1 149 ? -22.558 -23.610 29.963 1.00 8.21 ? 133 GLU B O 1 ATOM 3996 C CB . GLU B 1 149 ? -24.351 -25.866 29.439 1.00 5.45 ? 133 GLU B CB 1 ATOM 3997 C CG . GLU B 1 149 ? -24.354 -25.523 27.958 1.00 5.64 ? 133 GLU B CG 1 ATOM 3998 C CD . GLU B 1 149 ? -24.478 -26.743 27.065 1.00 8.28 ? 133 GLU B CD 1 ATOM 3999 O OE1 . GLU B 1 149 ? -25.409 -27.547 27.279 1.00 16.69 ? 133 GLU B OE1 1 ATOM 4000 O OE2 . GLU B 1 149 ? -23.644 -26.897 26.147 1.00 7.45 ? 133 GLU B OE2 1 ATOM 4001 N N . ASN B 1 150 ? -24.391 -22.342 29.676 1.00 10.27 ? 134 ASN B N 1 ATOM 4002 C CA . ASN B 1 150 ? -23.640 -21.151 29.287 1.00 5.47 ? 134 ASN B CA 1 ATOM 4003 C C . ASN B 1 150 ? -23.692 -20.057 30.349 1.00 5.73 ? 134 ASN B C 1 ATOM 4004 O O . ASN B 1 150 ? -22.918 -19.104 30.300 1.00 7.52 ? 134 ASN B O 1 ATOM 4005 C CB . ASN B 1 150 ? -24.174 -20.606 27.961 1.00 4.33 ? 134 ASN B CB 1 ATOM 4006 C CG . ASN B 1 150 ? -24.013 -21.591 26.823 1.00 4.27 ? 134 ASN B CG 1 ATOM 4007 O OD1 . ASN B 1 150 ? -24.992 -22.121 26.299 1.00 5.06 ? 134 ASN B OD1 1 ATOM 4008 N ND2 . ASN B 1 150 ? -22.770 -21.841 26.436 1.00 6.68 ? 134 ASN B ND2 1 ATOM 4009 N N . LEU B 1 151 ? -24.595 -20.207 31.313 1.00 8.14 ? 135 LEU B N 1 ATOM 4010 C CA . LEU B 1 151 ? -24.834 -19.170 32.311 1.00 6.75 ? 135 LEU B CA 1 ATOM 4011 C C . LEU B 1 151 ? -24.146 -19.504 33.629 1.00 4.92 ? 135 LEU B C 1 ATOM 4012 O O . LEU B 1 151 ? -24.156 -20.655 34.066 1.00 4.89 ? 135 LEU B O 1 ATOM 4013 C CB . LEU B 1 151 ? -26.338 -19.023 32.546 1.00 6.99 ? 135 LEU B CB 1 ATOM 4014 C CG . LEU B 1 151 ? -26.908 -17.617 32.754 1.00 5.23 ? 135 LEU B CG 1 ATOM 4015 C CD1 . LEU B 1 151 ? -28.204 -17.706 33.547 1.00 5.02 ? 135 LEU B CD1 1 ATOM 4016 C CD2 . LEU B 1 151 ? -25.920 -16.683 33.438 1.00 7.34 ? 135 LEU B CD2 1 ATOM 4017 N N . LYS B 1 152 ? -23.549 -18.495 34.260 1.00 4.65 ? 136 LYS B N 1 ATOM 4018 C CA . LYS B 1 152 ? -22.933 -18.671 35.571 1.00 3.74 ? 136 LYS B CA 1 ATOM 4019 C C . LYS B 1 152 ? -22.905 -17.358 36.353 1.00 4.40 ? 136 LYS B C 1 ATOM 4020 O O . LYS B 1 152 ? -22.877 -16.275 35.769 1.00 5.11 ? 136 LYS B O 1 ATOM 4021 C CB . LYS B 1 152 ? -21.512 -19.216 35.423 1.00 7.40 ? 136 LYS B CB 1 ATOM 4022 C CG . LYS B 1 152 ? -20.424 -18.163 35.575 1.00 9.01 ? 136 LYS B CG 1 ATOM 4023 C CD . LYS B 1 152 ? -19.059 -18.717 35.208 1.00 8.31 ? 136 LYS B CD 1 ATOM 4024 C CE . LYS B 1 152 ? -18.004 -17.625 35.203 1.00 18.35 ? 136 LYS B CE 1 ATOM 4025 N NZ . LYS B 1 152 ? -17.121 -17.719 34.009 1.00 25.02 ? 136 LYS B NZ 1 ATOM 4026 N N . TYR B 1 153 ? -22.916 -17.469 37.679 1.00 8.41 ? 137 TYR B N 1 ATOM 4027 C CA . TYR B 1 153 ? -22.837 -16.308 38.558 1.00 5.63 ? 137 TYR B CA 1 ATOM 4028 C C . TYR B 1 153 ? -21.670 -16.462 39.527 1.00 5.40 ? 137 TYR B C 1 ATOM 4029 O O . TYR B 1 153 ? -21.398 -17.560 40.010 1.00 4.51 ? 137 TYR B O 1 ATOM 4030 C CB . TYR B 1 153 ? -24.129 -16.156 39.363 1.00 5.69 ? 137 TYR B CB 1 ATOM 4031 C CG . TYR B 1 153 ? -25.378 -15.982 38.526 1.00 10.38 ? 137 TYR B CG 1 ATOM 4032 C CD1 . TYR B 1 153 ? -25.939 -17.055 37.844 1.00 9.51 ? 137 TYR B CD1 1 ATOM 4033 C CD2 . TYR B 1 153 ? -26.007 -14.747 38.435 1.00 9.42 ? 137 TYR B CD2 1 ATOM 4034 C CE1 . TYR B 1 153 ? -27.083 -16.898 37.085 1.00 7.86 ? 137 TYR B CE1 1 ATOM 4035 C CE2 . TYR B 1 153 ? -27.151 -14.582 37.680 1.00 7.29 ? 137 TYR B CE2 1 ATOM 4036 C CZ . TYR B 1 153 ? -27.686 -15.660 37.008 1.00 8.56 ? 137 TYR B CZ 1 ATOM 4037 O OH . TYR B 1 153 ? -28.826 -15.498 36.254 1.00 15.95 ? 137 TYR B OH 1 ATOM 4038 N N . SER B 1 154 ? -20.982 -15.361 39.809 1.00 6.26 ? 138 SER B N 1 ATOM 4039 C CA . SER B 1 154 ? -19.941 -15.352 40.831 1.00 6.75 ? 138 SER B CA 1 ATOM 4040 C C . SER B 1 154 ? -20.448 -14.596 42.057 1.00 7.76 ? 138 SER B C 1 ATOM 4041 O O . SER B 1 154 ? -20.836 -13.434 41.959 1.00 6.45 ? 138 SER B O 1 ATOM 4042 C CB . SER B 1 154 ? -18.661 -14.706 40.294 1.00 8.72 ? 138 SER B CB 1 ATOM 4043 O OG . SER B 1 154 ? -18.160 -15.422 39.179 1.00 11.04 ? 138 SER B OG 1 ATOM 4044 N N . VAL B 1 155 ? -20.448 -15.263 43.207 1.00 9.37 ? 139 VAL B N 1 ATOM 4045 C CA . VAL B 1 155 ? -20.985 -14.683 44.433 1.00 8.56 ? 139 VAL B CA 1 ATOM 4046 C C . VAL B 1 155 ? -19.945 -14.721 45.547 1.00 5.81 ? 139 VAL B C 1 ATOM 4047 O O . VAL B 1 155 ? -19.441 -15.788 45.892 1.00 10.99 ? 139 VAL B O 1 ATOM 4048 C CB . VAL B 1 155 ? -22.235 -15.452 44.896 1.00 8.03 ? 139 VAL B CB 1 ATOM 4049 C CG1 . VAL B 1 155 ? -22.751 -14.896 46.212 1.00 5.61 ? 139 VAL B CG1 1 ATOM 4050 C CG2 . VAL B 1 155 ? -23.315 -15.391 43.827 1.00 9.46 ? 139 VAL B CG2 1 ATOM 4051 N N . ILE B 1 156 ? -19.629 -13.561 46.113 1.00 4.27 ? 140 ILE B N 1 ATOM 4052 C CA . ILE B 1 156 ? -18.614 -13.490 47.158 1.00 8.07 ? 140 ILE B CA 1 ATOM 4053 C C . ILE B 1 156 ? -19.241 -13.418 48.549 1.00 5.49 ? 140 ILE B C 1 ATOM 4054 O O . ILE B 1 156 ? -20.119 -12.596 48.811 1.00 5.62 ? 140 ILE B O 1 ATOM 4055 C CB . ILE B 1 156 ? -17.657 -12.295 46.948 1.00 4.69 ? 140 ILE B CB 1 ATOM 4056 C CG1 . ILE B 1 156 ? -16.506 -12.354 47.954 1.00 9.20 ? 140 ILE B CG1 1 ATOM 4057 C CG2 . ILE B 1 156 ? -18.398 -10.976 47.071 1.00 15.02 ? 140 ILE B CG2 1 ATOM 4058 C CD1 . ILE B 1 156 ? -15.347 -11.432 47.617 1.00 6.68 ? 140 ILE B CD1 1 ATOM 4059 N N . VAL B 1 157 ? -18.785 -14.301 49.431 1.00 5.81 ? 141 VAL B N 1 ATOM 4060 C CA . VAL B 1 157 ? -19.242 -14.322 50.815 1.00 7.62 ? 141 VAL B CA 1 ATOM 4061 C C . VAL B 1 157 ? -18.092 -13.930 51.734 1.00 8.90 ? 141 VAL B C 1 ATOM 4062 O O . VAL B 1 157 ? -17.064 -14.605 51.769 1.00 9.98 ? 141 VAL B O 1 ATOM 4063 C CB . VAL B 1 157 ? -19.754 -15.715 51.218 1.00 10.05 ? 141 VAL B CB 1 ATOM 4064 C CG1 . VAL B 1 157 ? -20.271 -15.694 52.647 1.00 8.54 ? 141 VAL B CG1 1 ATOM 4065 C CG2 . VAL B 1 157 ? -20.841 -16.173 50.262 1.00 6.69 ? 141 VAL B CG2 1 ATOM 4066 N N . THR B 1 158 ? -18.269 -12.842 52.477 1.00 14.73 ? 142 THR B N 1 ATOM 4067 C CA . THR B 1 158 ? -17.194 -12.301 53.302 1.00 9.60 ? 142 THR B CA 1 ATOM 4068 C C . THR B 1 158 ? -17.579 -12.221 54.776 1.00 11.24 ? 142 THR B C 1 ATOM 4069 O O . THR B 1 158 ? -18.552 -11.562 55.141 1.00 11.03 ? 142 THR B O 1 ATOM 4070 C CB . THR B 1 158 ? -16.789 -10.891 52.833 1.00 15.53 ? 142 THR B CB 1 ATOM 4071 O OG1 . THR B 1 158 ? -16.524 -10.908 51.424 1.00 18.99 ? 142 THR B OG1 1 ATOM 4072 C CG2 . THR B 1 158 ? -15.550 -10.409 53.578 1.00 12.84 ? 142 THR B CG2 1 ATOM 4073 N N . VAL B 1 159 ? -16.803 -12.898 55.616 1.00 18.97 ? 143 VAL B N 1 ATOM 4074 C CA . VAL B 1 159 ? -16.948 -12.785 57.063 1.00 20.17 ? 143 VAL B CA 1 ATOM 4075 C C . VAL B 1 159 ? -15.904 -11.804 57.580 1.00 21.57 ? 143 VAL B C 1 ATOM 4076 O O . VAL B 1 159 ? -14.703 -12.021 57.417 1.00 24.10 ? 143 VAL B O 1 ATOM 4077 C CB . VAL B 1 159 ? -16.761 -14.142 57.763 1.00 22.58 ? 143 VAL B CB 1 ATOM 4078 C CG1 . VAL B 1 159 ? -16.998 -14.005 59.258 1.00 20.81 ? 143 VAL B CG1 1 ATOM 4079 C CG2 . VAL B 1 159 ? -17.707 -15.170 57.176 1.00 12.52 ? 143 VAL B CG2 1 ATOM 4080 N N . HIS B 1 160 ? -16.367 -10.724 58.202 1.00 22.08 ? 144 HIS B N 1 ATOM 4081 C CA . HIS B 1 160 ? -15.482 -9.641 58.609 1.00 18.56 ? 144 HIS B CA 1 ATOM 4082 C C . HIS B 1 160 ? -14.825 -9.903 59.959 1.00 27.65 ? 144 HIS B C 1 ATOM 4083 O O . HIS B 1 160 ? -15.375 -9.562 61.006 1.00 29.21 ? 144 HIS B O 1 ATOM 4084 C CB . HIS B 1 160 ? -16.254 -8.321 58.645 1.00 25.99 ? 144 HIS B CB 1 ATOM 4085 C CG . HIS B 1 160 ? -16.682 -7.839 57.294 1.00 20.53 ? 144 HIS B CG 1 ATOM 4086 N ND1 . HIS B 1 160 ? -15.921 -6.970 56.541 1.00 24.12 ? 144 HIS B ND1 1 ATOM 4087 C CD2 . HIS B 1 160 ? -17.786 -8.107 56.560 1.00 15.62 ? 144 HIS B CD2 1 ATOM 4088 C CE1 . HIS B 1 160 ? -16.541 -6.723 55.400 1.00 29.26 ? 144 HIS B CE1 1 ATOM 4089 N NE2 . HIS B 1 160 ? -17.674 -7.400 55.386 1.00 31.59 ? 144 HIS B NE2 1 ATOM 4090 N N . THR B 1 161 ? -13.639 -10.501 59.923 1.00 32.11 ? 145 THR B N 1 ATOM 4091 C CA . THR B 1 161 ? -12.863 -10.749 61.130 1.00 38.19 ? 145 THR B CA 1 ATOM 4092 C C . THR B 1 161 ? -12.128 -9.481 61.548 1.00 43.64 ? 145 THR B C 1 ATOM 4093 O O . THR B 1 161 ? -12.299 -8.989 62.663 1.00 62.32 ? 145 THR B O 1 ATOM 4094 C CB . THR B 1 161 ? -11.829 -11.871 60.914 1.00 45.17 ? 145 THR B CB 1 ATOM 4095 O OG1 . THR B 1 161 ? -12.500 -13.086 60.557 1.00 38.13 ? 145 THR B OG1 1 ATOM 4096 C CG2 . THR B 1 161 ? -11.008 -12.099 62.176 1.00 52.81 ? 145 THR B CG2 1 ATOM 4097 N N . HIS B 1 174 ? -10.584 -11.645 52.750 1.00 42.59 ? 158 HIS B N 1 ATOM 4098 C CA . HIS B 1 174 ? -10.652 -13.014 52.257 1.00 37.25 ? 158 HIS B CA 1 ATOM 4099 C C . HIS B 1 174 ? -12.093 -13.508 52.183 1.00 28.97 ? 158 HIS B C 1 ATOM 4100 O O . HIS B 1 174 ? -12.553 -14.246 53.055 1.00 29.41 ? 158 HIS B O 1 ATOM 4101 C CB . HIS B 1 174 ? -9.830 -13.944 53.150 1.00 46.23 ? 158 HIS B CB 1 ATOM 4102 C CG . HIS B 1 174 ? -10.067 -13.738 54.614 1.00 49.45 ? 158 HIS B CG 1 ATOM 4103 N ND1 . HIS B 1 174 ? -11.102 -14.346 55.292 1.00 50.83 ? 158 HIS B ND1 1 ATOM 4104 C CD2 . HIS B 1 174 ? -9.409 -12.985 55.525 1.00 52.01 ? 158 HIS B CD2 1 ATOM 4105 C CE1 . HIS B 1 174 ? -11.066 -13.979 56.561 1.00 56.94 ? 158 HIS B CE1 1 ATOM 4106 N NE2 . HIS B 1 174 ? -10.050 -13.154 56.729 1.00 53.94 ? 158 HIS B NE2 1 ATOM 4107 N N . GLY B 1 175 ? -12.801 -13.087 51.141 1.00 17.63 ? 159 GLY B N 1 ATOM 4108 C CA . GLY B 1 175 ? -14.138 -13.582 50.876 1.00 13.77 ? 159 GLY B CA 1 ATOM 4109 C C . GLY B 1 175 ? -14.072 -14.765 49.931 1.00 11.38 ? 159 GLY B C 1 ATOM 4110 O O . GLY B 1 175 ? -13.197 -14.825 49.067 1.00 14.06 ? 159 GLY B O 1 ATOM 4111 N N . THR B 1 176 ? -14.993 -15.708 50.091 1.00 12.85 ? 160 THR B N 1 ATOM 4112 C CA . THR B 1 176 ? -15.008 -16.898 49.250 1.00 9.59 ? 160 THR B CA 1 ATOM 4113 C C . THR B 1 176 ? -15.948 -16.694 48.068 1.00 9.87 ? 160 THR B C 1 ATOM 4114 O O . THR B 1 176 ? -17.151 -16.505 48.243 1.00 12.68 ? 160 THR B O 1 ATOM 4115 C CB . THR B 1 176 ? -15.446 -18.146 50.036 1.00 9.71 ? 160 THR B CB 1 ATOM 4116 O OG1 . THR B 1 176 ? -14.682 -18.249 51.244 1.00 14.96 ? 160 THR B OG1 1 ATOM 4117 C CG2 . THR B 1 176 ? -15.236 -19.396 49.200 1.00 11.49 ? 160 THR B CG2 1 ATOM 4118 N N . ILE B 1 177 ? -15.388 -16.730 46.863 1.00 11.41 ? 161 ILE B N 1 ATOM 4119 C CA . ILE B 1 177 ? -16.165 -16.526 45.646 1.00 9.02 ? 161 ILE B CA 1 ATOM 4120 C C . ILE B 1 177 ? -16.794 -17.834 45.178 1.00 10.36 ? 161 ILE B C 1 ATOM 4121 O O . ILE B 1 177 ? -16.113 -18.702 44.632 1.00 13.91 ? 161 ILE B O 1 ATOM 4122 C CB . ILE B 1 177 ? -15.288 -15.953 44.517 1.00 8.86 ? 161 ILE B CB 1 ATOM 4123 C CG1 . ILE B 1 177 ? -14.682 -14.616 44.951 1.00 6.28 ? 161 ILE B CG1 1 ATOM 4124 C CG2 . ILE B 1 177 ? -16.104 -15.773 43.244 1.00 6.48 ? 161 ILE B CG2 1 ATOM 4125 C CD1 . ILE B 1 177 ? -13.539 -14.145 44.081 1.00 6.59 ? 161 ILE B CD1 1 ATOM 4126 N N . ALA B 1 178 ? -18.098 -17.968 45.401 1.00 10.98 ? 162 ALA B N 1 ATOM 4127 C CA . ALA B 1 178 ? -18.832 -19.161 44.999 1.00 7.86 ? 162 ALA B CA 1 ATOM 4128 C C . ALA B 1 178 ? -19.314 -19.041 43.559 1.00 9.86 ? 162 ALA B C 1 ATOM 4129 O O . ALA B 1 178 ? -19.755 -17.975 43.129 1.00 11.06 ? 162 ALA B O 1 ATOM 4130 C CB . ALA B 1 178 ? -20.009 -19.381 45.925 1.00 7.52 ? 162 ALA B CB 1 ATOM 4131 N N . THR B 1 179 ? -19.231 -20.140 42.818 1.00 10.33 ? 163 THR B N 1 ATOM 4132 C CA . THR B 1 179 ? -19.688 -20.165 41.435 1.00 6.82 ? 163 THR B CA 1 ATOM 4133 C C . THR B 1 179 ? -21.029 -20.887 41.345 1.00 6.99 ? 163 THR B C 1 ATOM 4134 O O . THR B 1 179 ? -21.141 -22.055 41.716 1.00 13.17 ? 163 THR B O 1 ATOM 4135 C CB . THR B 1 179 ? -18.673 -20.871 40.518 1.00 6.83 ? 163 THR B CB 1 ATOM 4136 O OG1 . THR B 1 179 ? -17.356 -20.370 40.779 1.00 9.33 ? 163 THR B OG1 1 ATOM 4137 C CG2 . THR B 1 179 ? -19.021 -20.635 39.059 1.00 7.35 ? 163 THR B CG2 1 ATOM 4138 N N . ILE B 1 180 ? -22.043 -20.183 40.852 1.00 6.04 ? 164 ILE B N 1 ATOM 4139 C CA . ILE B 1 180 ? -23.385 -20.742 40.740 1.00 5.30 ? 164 ILE B CA 1 ATOM 4140 C C . ILE B 1 180 ? -23.799 -20.866 39.281 1.00 4.36 ? 164 ILE B C 1 ATOM 4141 O O . ILE B 1 180 ? -23.430 -20.040 38.450 1.00 5.01 ? 164 ILE B O 1 ATOM 4142 C CB . ILE B 1 180 ? -24.418 -19.854 41.459 1.00 5.46 ? 164 ILE B CB 1 ATOM 4143 C CG1 . ILE B 1 180 ? -24.040 -19.670 42.931 1.00 5.63 ? 164 ILE B CG1 1 ATOM 4144 C CG2 . ILE B 1 180 ? -25.814 -20.450 41.331 1.00 4.72 ? 164 ILE B CG2 1 ATOM 4145 C CD1 . ILE B 1 180 ? -24.098 -20.940 43.747 1.00 5.94 ? 164 ILE B CD1 1 ATOM 4146 N N . THR B 1 181 ? -24.559 -21.910 38.973 1.00 5.34 ? 165 THR B N 1 ATOM 4147 C CA . THR B 1 181 ? -25.096 -22.095 37.633 1.00 5.63 ? 165 THR B CA 1 ATOM 4148 C C . THR B 1 181 ? -26.479 -22.729 37.735 1.00 4.91 ? 165 THR B C 1 ATOM 4149 O O . THR B 1 181 ? -26.851 -23.253 38.786 1.00 8.43 ? 165 THR B O 1 ATOM 4150 C CB . THR B 1 181 ? -24.193 -23.001 36.778 1.00 4.32 ? 165 THR B CB 1 ATOM 4151 O OG1 . THR B 1 181 ? -24.483 -24.373 37.067 1.00 6.86 ? 165 THR B OG1 1 ATOM 4152 C CG2 . THR B 1 181 ? -22.730 -22.718 37.049 1.00 3.73 ? 165 THR B CG2 1 ATOM 4153 N N . PRO B 1 182 ? -27.259 -22.661 36.647 1.00 4.42 ? 166 PRO B N 1 ATOM 4154 C CA . PRO B 1 182 ? -28.594 -23.271 36.610 1.00 4.07 ? 166 PRO B CA 1 ATOM 4155 C C . PRO B 1 182 ? -28.598 -24.749 36.990 1.00 4.37 ? 166 PRO B C 1 ATOM 4156 O O . PRO B 1 182 ? -29.442 -25.174 37.778 1.00 9.68 ? 166 PRO B O 1 ATOM 4157 C CB . PRO B 1 182 ? -29.016 -23.093 35.150 1.00 6.45 ? 166 PRO B CB 1 ATOM 4158 C CG . PRO B 1 182 ? -28.287 -21.868 34.706 1.00 5.46 ? 166 PRO B CG 1 ATOM 4159 C CD . PRO B 1 182 ? -26.968 -21.900 35.421 1.00 4.55 ? 166 PRO B CD 1 ATOM 4160 N N . GLN B 1 183 ? -27.652 -25.513 36.457 1.00 7.31 ? 167 GLN B N 1 ATOM 4161 C CA . GLN B 1 183 ? -27.577 -26.945 36.731 1.00 5.49 ? 167 GLN B CA 1 ATOM 4162 C C . GLN B 1 183 ? -26.976 -27.244 38.103 1.00 7.31 ? 167 GLN B C 1 ATOM 4163 O O . GLN B 1 183 ? -27.413 -28.173 38.789 1.00 9.46 ? 167 GLN B O 1 ATOM 4164 C CB . GLN B 1 183 ? -26.768 -27.646 35.641 1.00 6.63 ? 167 GLN B CB 1 ATOM 4165 C CG . GLN B 1 183 ? -27.343 -27.470 34.251 1.00 5.15 ? 167 GLN B CG 1 ATOM 4166 C CD . GLN B 1 183 ? -26.549 -28.213 33.200 1.00 5.24 ? 167 GLN B CD 1 ATOM 4167 O OE1 . GLN B 1 183 ? -26.747 -29.409 32.987 1.00 8.79 ? 167 GLN B OE1 1 ATOM 4168 N NE2 . GLN B 1 183 ? -25.637 -27.510 32.541 1.00 7.29 ? 167 GLN B NE2 1 ATOM 4169 N N . ALA B 1 184 ? -25.970 -26.469 38.495 1.00 6.99 ? 168 ALA B N 1 ATOM 4170 C CA . ALA B 1 184 ? -25.378 -26.603 39.821 1.00 5.35 ? 168 ALA B CA 1 ATOM 4171 C C . ALA B 1 184 ? -25.725 -25.389 40.674 1.00 5.68 ? 168 ALA B C 1 ATOM 4172 O O . ALA B 1 184 ? -24.898 -24.499 40.861 1.00 6.29 ? 168 ALA B O 1 ATOM 4173 C CB . ALA B 1 184 ? -23.881 -26.761 39.713 1.00 5.31 ? 168 ALA B CB 1 ATOM 4174 N N . PRO B 1 185 ? -26.962 -25.346 41.190 1.00 6.44 ? 169 PRO B N 1 ATOM 4175 C CA . PRO B 1 185 ? -27.472 -24.179 41.917 1.00 10.08 ? 169 PRO B CA 1 ATOM 4176 C C . PRO B 1 185 ? -26.956 -24.044 43.349 1.00 11.71 ? 169 PRO B C 1 ATOM 4177 O O . PRO B 1 185 ? -27.014 -22.947 43.903 1.00 7.21 ? 169 PRO B O 1 ATOM 4178 C CB . PRO B 1 185 ? -28.983 -24.416 41.929 1.00 9.11 ? 169 PRO B CB 1 ATOM 4179 C CG . PRO B 1 185 ? -29.130 -25.893 41.870 1.00 5.77 ? 169 PRO B CG 1 ATOM 4180 C CD . PRO B 1 185 ? -27.996 -26.383 41.022 1.00 8.59 ? 169 PRO B CD 1 ATOM 4181 N N . THR B 1 186 ? -26.462 -25.130 43.938 1.00 15.42 ? 170 THR B N 1 ATOM 4182 C CA . THR B 1 186 ? -26.021 -25.089 45.329 1.00 9.12 ? 170 THR B CA 1 ATOM 4183 C C . THR B 1 186 ? -24.503 -25.116 45.457 1.00 11.69 ? 170 THR B C 1 ATOM 4184 O O . THR B 1 186 ? -23.816 -25.787 44.687 1.00 16.20 ? 170 THR B O 1 ATOM 4185 C CB . THR B 1 186 ? -26.596 -26.263 46.151 1.00 17.79 ? 170 THR B CB 1 ATOM 4186 O OG1 . THR B 1 186 ? -25.899 -27.472 45.825 1.00 31.96 ? 170 THR B OG1 1 ATOM 4187 C CG2 . THR B 1 186 ? -28.084 -26.435 45.881 1.00 19.28 ? 170 THR B CG2 1 ATOM 4188 N N . SER B 1 187 ? -23.992 -24.371 46.433 1.00 18.70 ? 171 SER B N 1 ATOM 4189 C CA . SER B 1 187 ? -22.574 -24.396 46.767 1.00 7.65 ? 171 SER B CA 1 ATOM 4190 C C . SER B 1 187 ? -22.401 -24.444 48.279 1.00 6.06 ? 171 SER B C 1 ATOM 4191 O O . SER B 1 187 ? -23.089 -23.734 49.012 1.00 6.00 ? 171 SER B O 1 ATOM 4192 C CB . SER B 1 187 ? -21.864 -23.162 46.213 1.00 6.64 ? 171 SER B CB 1 ATOM 4193 O OG . SER B 1 187 ? -20.460 -23.273 46.376 1.00 10.12 ? 171 SER B OG 1 ATOM 4194 N N . GLU B 1 188 ? -21.478 -25.280 48.741 1.00 10.82 ? 172 GLU B N 1 ATOM 4195 C CA . GLU B 1 188 ? -21.201 -25.407 50.167 1.00 10.73 ? 172 GLU B CA 1 ATOM 4196 C C . GLU B 1 188 ? -19.833 -24.808 50.481 1.00 11.56 ? 172 GLU B C 1 ATOM 4197 O O . GLU B 1 188 ? -18.829 -25.188 49.878 1.00 12.17 ? 172 GLU B O 1 ATOM 4198 C CB . GLU B 1 188 ? -21.238 -26.878 50.587 1.00 11.35 ? 172 GLU B CB 1 ATOM 4199 C CG . GLU B 1 188 ? -22.404 -27.667 49.999 1.00 16.38 ? 172 GLU B CG 1 ATOM 4200 C CD . GLU B 1 188 ? -23.403 -28.118 51.047 1.00 19.10 ? 172 GLU B CD 1 ATOM 4201 O OE1 . GLU B 1 188 ? -24.607 -28.207 50.722 1.00 16.59 ? 172 GLU B OE1 1 ATOM 4202 O OE2 . GLU B 1 188 ? -22.987 -28.390 52.193 1.00 22.47 ? 172 GLU B OE2 1 ATOM 4203 N N . ILE B 1 189 ? -19.796 -23.877 51.429 1.00 9.41 ? 173 ILE B N 1 ATOM 4204 C CA . ILE B 1 189 ? -18.553 -23.202 51.787 1.00 15.93 ? 173 ILE B CA 1 ATOM 4205 C C . ILE B 1 189 ? -18.419 -23.068 53.300 1.00 11.95 ? 173 ILE B C 1 ATOM 4206 O O . ILE B 1 189 ? -19.354 -22.655 53.984 1.00 13.06 ? 173 ILE B O 1 ATOM 4207 C CB . ILE B 1 189 ? -18.454 -21.812 51.120 1.00 18.77 ? 173 ILE B CB 1 ATOM 4208 C CG1 . ILE B 1 189 ? -19.717 -20.992 51.399 1.00 11.83 ? 173 ILE B CG1 1 ATOM 4209 C CG2 . ILE B 1 189 ? -18.225 -21.965 49.619 1.00 19.09 ? 173 ILE B CG2 1 ATOM 4210 C CD1 . ILE B 1 189 ? -19.876 -19.788 50.502 1.00 7.86 ? 173 ILE B CD1 1 ATOM 4211 N N . GLN B 1 190 ? -17.245 -23.422 53.811 1.00 15.85 ? 174 GLN B N 1 ATOM 4212 C CA . GLN B 1 190 ? -16.996 -23.424 55.247 1.00 15.16 ? 174 GLN B CA 1 ATOM 4213 C C . GLN B 1 190 ? -16.528 -22.046 55.703 1.00 15.06 ? 174 GLN B C 1 ATOM 4214 O O . GLN B 1 190 ? -15.453 -21.588 55.315 1.00 23.47 ? 174 GLN B O 1 ATOM 4215 C CB . GLN B 1 190 ? -15.942 -24.477 55.595 1.00 18.22 ? 174 GLN B CB 1 ATOM 4216 C CG . GLN B 1 190 ? -16.115 -25.096 56.971 1.00 19.52 ? 174 GLN B CG 1 ATOM 4217 C CD . GLN B 1 190 ? -17.324 -26.008 57.047 1.00 12.05 ? 174 GLN B CD 1 ATOM 4218 O OE1 . GLN B 1 190 ? -17.893 -26.390 56.024 1.00 21.87 ? 174 GLN B OE1 1 ATOM 4219 N NE2 . GLN B 1 190 ? -17.725 -26.359 58.262 1.00 9.50 ? 174 GLN B NE2 1 ATOM 4220 N N . LEU B 1 191 ? -17.343 -21.392 56.525 1.00 14.22 ? 175 LEU B N 1 ATOM 4221 C CA . LEU B 1 191 ? -17.046 -20.045 56.998 1.00 14.94 ? 175 LEU B CA 1 ATOM 4222 C C . LEU B 1 191 ? -16.411 -20.052 58.384 1.00 20.36 ? 175 LEU B C 1 ATOM 4223 O O . LEU B 1 191 ? -16.574 -21.001 59.151 1.00 16.93 ? 175 LEU B O 1 ATOM 4224 C CB . LEU B 1 191 ? -18.328 -19.216 57.046 1.00 16.67 ? 175 LEU B CB 1 ATOM 4225 C CG . LEU B 1 191 ? -19.052 -18.993 55.720 1.00 15.34 ? 175 LEU B CG 1 ATOM 4226 C CD1 . LEU B 1 191 ? -20.339 -18.220 55.952 1.00 11.89 ? 175 LEU B CD1 1 ATOM 4227 C CD2 . LEU B 1 191 ? -18.161 -18.261 54.733 1.00 18.72 ? 175 LEU B CD2 1 ATOM 4228 N N . THR B 1 192 ? -15.693 -18.978 58.698 1.00 22.33 ? 176 THR B N 1 ATOM 4229 C CA . THR B 1 192 ? -15.121 -18.797 60.024 1.00 27.55 ? 176 THR B CA 1 ATOM 4230 C C . THR B 1 192 ? -16.210 -18.385 61.011 1.00 26.93 ? 176 THR B C 1 ATOM 4231 O O . THR B 1 192 ? -16.951 -17.434 60.763 1.00 32.60 ? 176 THR B O 1 ATOM 4232 C CB . THR B 1 192 ? -14.021 -17.718 60.016 1.00 35.14 ? 176 THR B CB 1 ATOM 4233 O OG1 . THR B 1 192 ? -12.937 -18.140 59.181 1.00 30.79 ? 176 THR B OG1 1 ATOM 4234 C CG2 . THR B 1 192 ? -13.503 -17.466 61.423 1.00 32.37 ? 176 THR B CG2 1 ATOM 4235 N N . ASP B 1 193 ? -16.311 -19.111 62.121 1.00 25.59 ? 177 ASP B N 1 ATOM 4236 C CA . ASP B 1 193 ? -17.290 -18.811 63.168 1.00 23.85 ? 177 ASP B CA 1 ATOM 4237 C C . ASP B 1 193 ? -18.741 -19.118 62.772 1.00 21.30 ? 177 ASP B C 1 ATOM 4238 O O . ASP B 1 193 ? -19.603 -19.242 63.641 1.00 23.66 ? 177 ASP B O 1 ATOM 4239 C CB . ASP B 1 193 ? -17.174 -17.348 63.620 1.00 26.97 ? 177 ASP B CB 1 ATOM 4240 C CG . ASP B 1 193 ? -16.334 -17.186 64.875 1.00 36.71 ? 177 ASP B CG 1 ATOM 4241 O OD1 . ASP B 1 193 ? -16.887 -17.331 65.986 1.00 41.31 ? 177 ASP B OD1 1 ATOM 4242 O OD2 . ASP B 1 193 ? -15.123 -16.906 64.752 1.00 40.34 ? 177 ASP B OD2 1 ATOM 4243 N N . TYR B 1 194 ? -19.013 -19.243 61.474 1.00 20.51 ? 178 TYR B N 1 ATOM 4244 C CA . TYR B 1 194 ? -20.371 -19.516 61.003 1.00 18.44 ? 178 TYR B CA 1 ATOM 4245 C C . TYR B 1 194 ? -20.562 -20.981 60.621 1.00 23.31 ? 178 TYR B C 1 ATOM 4246 O O . TYR B 1 194 ? -21.685 -21.486 60.621 1.00 26.66 ? 178 TYR B O 1 ATOM 4247 C CB . TYR B 1 194 ? -20.715 -18.612 59.815 1.00 17.20 ? 178 TYR B CB 1 ATOM 4248 C CG . TYR B 1 194 ? -21.204 -17.240 60.221 1.00 18.74 ? 178 TYR B CG 1 ATOM 4249 C CD1 . TYR B 1 194 ? -22.552 -17.007 60.460 1.00 16.59 ? 178 TYR B CD1 1 ATOM 4250 C CD2 . TYR B 1 194 ? -20.321 -16.178 60.370 1.00 18.50 ? 178 TYR B CD2 1 ATOM 4251 C CE1 . TYR B 1 194 ? -23.007 -15.758 60.834 1.00 10.79 ? 178 TYR B CE1 1 ATOM 4252 C CE2 . TYR B 1 194 ? -20.768 -14.924 60.744 1.00 11.84 ? 178 TYR B CE2 1 ATOM 4253 C CZ . TYR B 1 194 ? -22.111 -14.720 60.973 1.00 10.23 ? 178 TYR B CZ 1 ATOM 4254 O OH . TYR B 1 194 ? -22.561 -13.475 61.346 1.00 18.87 ? 178 TYR B OH 1 ATOM 4255 N N . GLY B 1 195 ? -19.466 -21.661 60.301 1.00 21.81 ? 179 GLY B N 1 ATOM 4256 C CA . GLY B 1 195 ? -19.524 -23.067 59.948 1.00 7.36 ? 179 GLY B CA 1 ATOM 4257 C C . GLY B 1 195 ? -19.900 -23.277 58.494 1.00 14.64 ? 179 GLY B C 1 ATOM 4258 O O . GLY B 1 195 ? -19.565 -22.464 57.633 1.00 15.65 ? 179 GLY B O 1 ATOM 4259 N N . ALA B 1 196 ? -20.613 -24.366 58.222 1.00 14.23 ? 180 ALA B N 1 ATOM 4260 C CA . ALA B 1 196 ? -20.971 -24.731 56.856 1.00 11.19 ? 180 ALA B CA 1 ATOM 4261 C C . ALA B 1 196 ? -22.177 -23.935 56.363 1.00 11.54 ? 180 ALA B C 1 ATOM 4262 O O . ALA B 1 196 ? -23.265 -24.024 56.932 1.00 13.17 ? 180 ALA B O 1 ATOM 4263 C CB . ALA B 1 196 ? -21.255 -26.224 56.770 1.00 10.38 ? 180 ALA B CB 1 ATOM 4264 N N . LEU B 1 197 ? -21.973 -23.154 55.306 1.00 13.29 ? 181 LEU B N 1 ATOM 4265 C CA . LEU B 1 197 ? -23.048 -22.381 54.695 1.00 9.52 ? 181 LEU B CA 1 ATOM 4266 C C . LEU B 1 197 ? -23.368 -22.927 53.310 1.00 10.06 ? 181 LEU B C 1 ATOM 4267 O O . LEU B 1 197 ? -22.468 -23.138 52.497 1.00 11.65 ? 181 LEU B O 1 ATOM 4268 C CB . LEU B 1 197 ? -22.645 -20.911 54.572 1.00 11.30 ? 181 LEU B CB 1 ATOM 4269 C CG . LEU B 1 197 ? -23.670 -20.017 53.868 1.00 7.30 ? 181 LEU B CG 1 ATOM 4270 C CD1 . LEU B 1 197 ? -24.811 -19.671 54.809 1.00 5.55 ? 181 LEU B CD1 1 ATOM 4271 C CD2 . LEU B 1 197 ? -23.020 -18.757 53.324 1.00 7.15 ? 181 LEU B CD2 1 ATOM 4272 N N . THR B 1 198 ? -24.651 -23.149 53.041 1.00 7.72 ? 182 THR B N 1 ATOM 4273 C CA . THR B 1 198 ? -25.082 -23.590 51.722 1.00 6.15 ? 182 THR B CA 1 ATOM 4274 C C . THR B 1 198 ? -25.783 -22.464 50.974 1.00 5.16 ? 182 THR B C 1 ATOM 4275 O O . THR B 1 198 ? -26.847 -22.000 51.383 1.00 5.60 ? 182 THR B O 1 ATOM 4276 C CB . THR B 1 198 ? -26.052 -24.779 51.807 1.00 6.99 ? 182 THR B CB 1 ATOM 4277 O OG1 . THR B 1 198 ? -25.482 -25.816 52.612 1.00 9.94 ? 182 THR B OG1 1 ATOM 4278 C CG2 . THR B 1 198 ? -26.346 -25.323 50.419 1.00 9.81 ? 182 THR B CG2 1 ATOM 4279 N N . LEU B 1 199 ? -25.180 -22.029 49.874 1.00 9.85 ? 183 LEU B N 1 ATOM 4280 C CA . LEU B 1 199 ? -25.837 -21.104 48.961 1.00 4.44 ? 183 LEU B CA 1 ATOM 4281 C C . LEU B 1 199 ? -26.712 -21.907 48.014 1.00 3.04 ? 183 LEU B C 1 ATOM 4282 O O . LEU B 1 199 ? -26.218 -22.775 47.301 1.00 9.33 ? 183 LEU B O 1 ATOM 4283 C CB . LEU B 1 199 ? -24.810 -20.316 48.143 1.00 6.48 ? 183 LEU B CB 1 ATOM 4284 C CG . LEU B 1 199 ? -24.063 -19.159 48.812 1.00 4.66 ? 183 LEU B CG 1 ATOM 4285 C CD1 . LEU B 1 199 ? -25.029 -18.074 49.254 1.00 7.86 ? 183 LEU B CD1 1 ATOM 4286 C CD2 . LEU B 1 199 ? -23.235 -19.647 49.983 1.00 10.63 ? 183 LEU B CD2 1 ATOM 4287 N N . ASP B 1 200 ? -28.011 -21.633 48.017 1.00 4.31 ? 184 ASP B N 1 ATOM 4288 C CA . ASP B 1 200 ? -28.921 -22.251 47.060 1.00 5.36 ? 184 ASP B CA 1 ATOM 4289 C C . ASP B 1 200 ? -29.601 -21.156 46.250 1.00 9.42 ? 184 ASP B C 1 ATOM 4290 O O . ASP B 1 200 ? -30.625 -20.611 46.660 1.00 9.95 ? 184 ASP B O 1 ATOM 4291 C CB . ASP B 1 200 ? -29.962 -23.109 47.778 1.00 5.02 ? 184 ASP B CB 1 ATOM 4292 C CG . ASP B 1 200 ? -30.730 -24.011 46.829 1.00 14.53 ? 184 ASP B CG 1 ATOM 4293 O OD1 . ASP B 1 200 ? -30.745 -23.725 45.612 1.00 17.00 ? 184 ASP B OD1 1 ATOM 4294 O OD2 . ASP B 1 200 ? -31.322 -25.006 47.301 1.00 17.22 ? 184 ASP B OD2 1 ATOM 4295 N N . CYS B 1 201 ? -29.018 -20.834 45.100 1.00 12.59 ? 185 CYS B N 1 ATOM 4296 C CA . CYS B 1 201 ? -29.447 -19.680 44.322 1.00 7.68 ? 185 CYS B CA 1 ATOM 4297 C C . CYS B 1 201 ? -30.061 -20.072 42.982 1.00 11.83 ? 185 CYS B C 1 ATOM 4298 O O . CYS B 1 201 ? -29.770 -21.136 42.435 1.00 24.82 ? 185 CYS B O 1 ATOM 4299 C CB . CYS B 1 201 ? -28.258 -18.747 44.088 1.00 8.85 ? 185 CYS B CB 1 ATOM 4300 S SG . CYS B 1 201 ? -27.437 -18.209 45.603 1.00 11.20 ? 185 CYS B SG 1 ATOM 4301 N N . SER B 1 202 ? -30.917 -19.198 42.465 1.00 12.28 ? 186 SER B N 1 ATOM 4302 C CA . SER B 1 202 ? -31.514 -19.381 41.148 1.00 12.31 ? 186 SER B CA 1 ATOM 4303 C C . SER B 1 202 ? -31.799 -18.017 40.528 1.00 14.56 ? 186 SER B C 1 ATOM 4304 O O . SER B 1 202 ? -32.200 -17.087 41.228 1.00 19.91 ? 186 SER B O 1 ATOM 4305 C CB . SER B 1 202 ? -32.807 -20.191 41.251 1.00 13.77 ? 186 SER B CB 1 ATOM 4306 O OG . SER B 1 202 ? -33.729 -19.571 42.130 1.00 18.65 ? 186 SER B OG 1 ATOM 4307 N N . PRO B 1 203 ? -31.593 -17.890 39.207 1.00 14.22 ? 187 PRO B N 1 ATOM 4308 C CA . PRO B 1 203 ? -31.814 -16.609 38.525 1.00 9.54 ? 187 PRO B CA 1 ATOM 4309 C C . PRO B 1 203 ? -33.226 -16.073 38.730 1.00 14.60 ? 187 PRO B C 1 ATOM 4310 O O . PRO B 1 203 ? -34.174 -16.855 38.800 1.00 20.81 ? 187 PRO B O 1 ATOM 4311 C CB . PRO B 1 203 ? -31.602 -16.958 37.047 1.00 10.51 ? 187 PRO B CB 1 ATOM 4312 C CG . PRO B 1 203 ? -30.759 -18.180 37.054 1.00 13.83 ? 187 PRO B CG 1 ATOM 4313 C CD . PRO B 1 203 ? -31.157 -18.944 38.276 1.00 10.28 ? 187 PRO B CD 1 ATOM 4314 N N . ARG B 1 204 ? -33.361 -14.754 38.830 1.00 16.23 ? 188 ARG B N 1 ATOM 4315 C CA . ARG B 1 204 ? -34.675 -14.136 38.925 1.00 11.40 ? 188 ARG B CA 1 ATOM 4316 C C . ARG B 1 204 ? -35.302 -14.061 37.541 1.00 20.11 ? 188 ARG B C 1 ATOM 4317 O O . ARG B 1 204 ? -34.614 -13.814 36.551 1.00 22.41 ? 188 ARG B O 1 ATOM 4318 C CB . ARG B 1 204 ? -34.579 -12.731 39.516 1.00 14.85 ? 188 ARG B CB 1 ATOM 4319 C CG . ARG B 1 204 ? -34.045 -12.672 40.936 1.00 15.12 ? 188 ARG B CG 1 ATOM 4320 C CD . ARG B 1 204 ? -34.414 -11.352 41.585 1.00 11.56 ? 188 ARG B CD 1 ATOM 4321 N NE . ARG B 1 204 ? -35.737 -11.401 42.201 1.00 18.16 ? 188 ARG B NE 1 ATOM 4322 C CZ . ARG B 1 204 ? -36.458 -10.333 42.530 1.00 23.35 ? 188 ARG B CZ 1 ATOM 4323 N NH1 . ARG B 1 204 ? -35.998 -9.110 42.300 1.00 18.67 ? 188 ARG B NH1 1 ATOM 4324 N NH2 . ARG B 1 204 ? -37.650 -10.485 43.087 1.00 27.22 ? 188 ARG B NH2 1 ATOM 4325 N N . THR B 1 205 ? -36.609 -14.278 37.478 1.00 22.25 ? 189 THR B N 1 ATOM 4326 C CA . THR B 1 205 ? -37.329 -14.209 36.215 1.00 14.90 ? 189 THR B CA 1 ATOM 4327 C C . THR B 1 205 ? -37.198 -12.820 35.600 1.00 13.76 ? 189 THR B C 1 ATOM 4328 O O . THR B 1 205 ? -37.565 -11.819 36.215 1.00 12.98 ? 189 THR B O 1 ATOM 4329 C CB . THR B 1 205 ? -38.820 -14.543 36.402 1.00 16.05 ? 189 THR B CB 1 ATOM 4330 O OG1 . THR B 1 205 ? -38.953 -15.879 36.900 1.00 21.73 ? 189 THR B OG1 1 ATOM 4331 C CG2 . THR B 1 205 ? -39.568 -14.420 35.081 1.00 13.01 ? 189 THR B CG2 1 ATOM 4332 N N . GLY B 1 206 ? -36.664 -12.770 34.384 1.00 16.40 ? 190 GLY B N 1 ATOM 4333 C CA . GLY B 1 206 ? -36.482 -11.520 33.671 1.00 9.75 ? 190 GLY B CA 1 ATOM 4334 C C . GLY B 1 206 ? -36.295 -11.783 32.191 1.00 10.44 ? 190 GLY B C 1 ATOM 4335 O O . GLY B 1 206 ? -37.267 -11.921 31.450 1.00 10.72 ? 190 GLY B O 1 ATOM 4336 N N . LEU B 1 207 ? -35.040 -11.853 31.758 1.00 13.92 ? 191 LEU B N 1 ATOM 4337 C CA . LEU B 1 207 ? -34.734 -12.254 30.391 1.00 12.38 ? 191 LEU B CA 1 ATOM 4338 C C . LEU B 1 207 ? -35.152 -13.702 30.171 1.00 14.75 ? 191 LEU B C 1 ATOM 4339 O O . LEU B 1 207 ? -34.907 -14.564 31.016 1.00 17.39 ? 191 LEU B O 1 ATOM 4340 C CB . LEU B 1 207 ? -33.239 -12.109 30.100 1.00 14.19 ? 191 LEU B CB 1 ATOM 4341 C CG . LEU B 1 207 ? -32.738 -10.756 29.591 1.00 17.37 ? 191 LEU B CG 1 ATOM 4342 C CD1 . LEU B 1 207 ? -31.233 -10.812 29.375 1.00 17.93 ? 191 LEU B CD1 1 ATOM 4343 C CD2 . LEU B 1 207 ? -33.443 -10.353 28.304 1.00 15.52 ? 191 LEU B CD2 1 ATOM 4344 N N . ASP B 1 208 ? -35.784 -13.965 29.033 1.00 16.89 ? 192 ASP B N 1 ATOM 4345 C CA . ASP B 1 208 ? -36.160 -15.323 28.664 1.00 15.60 ? 192 ASP B CA 1 ATOM 4346 C C . ASP B 1 208 ? -35.301 -15.767 27.490 1.00 10.41 ? 192 ASP B C 1 ATOM 4347 O O . ASP B 1 208 ? -35.346 -15.167 26.418 1.00 11.55 ? 192 ASP B O 1 ATOM 4348 C CB . ASP B 1 208 ? -37.644 -15.389 28.298 1.00 14.14 ? 192 ASP B CB 1 ATOM 4349 C CG . ASP B 1 208 ? -38.138 -16.812 28.125 1.00 11.66 ? 192 ASP B CG 1 ATOM 4350 O OD1 . ASP B 1 208 ? -37.420 -17.746 28.539 1.00 13.12 ? 192 ASP B OD1 1 ATOM 4351 O OD2 . ASP B 1 208 ? -39.249 -16.996 27.584 1.00 14.73 ? 192 ASP B OD2 1 ATOM 4352 N N . PHE B 1 209 ? -34.515 -16.818 27.698 1.00 10.18 ? 193 PHE B N 1 ATOM 4353 C CA . PHE B 1 209 ? -33.553 -17.254 26.693 1.00 10.67 ? 193 PHE B CA 1 ATOM 4354 C C . PHE B 1 209 ? -34.097 -18.368 25.804 1.00 12.19 ? 193 PHE B C 1 ATOM 4355 O O . PHE B 1 209 ? -33.431 -18.803 24.865 1.00 12.07 ? 193 PHE B O 1 ATOM 4356 C CB . PHE B 1 209 ? -32.244 -17.677 27.361 1.00 9.04 ? 193 PHE B CB 1 ATOM 4357 C CG . PHE B 1 209 ? -31.512 -16.540 28.012 1.00 10.92 ? 193 PHE B CG 1 ATOM 4358 C CD1 . PHE B 1 209 ? -31.089 -15.456 27.260 1.00 6.68 ? 193 PHE B CD1 1 ATOM 4359 C CD2 . PHE B 1 209 ? -31.251 -16.549 29.371 1.00 7.27 ? 193 PHE B CD2 1 ATOM 4360 C CE1 . PHE B 1 209 ? -30.420 -14.404 27.850 1.00 9.03 ? 193 PHE B CE1 1 ATOM 4361 C CE2 . PHE B 1 209 ? -30.579 -15.499 29.967 1.00 6.45 ? 193 PHE B CE2 1 ATOM 4362 C CZ . PHE B 1 209 ? -30.164 -14.425 29.206 1.00 6.80 ? 193 PHE B CZ 1 ATOM 4363 N N . ASN B 1 210 ? -35.307 -18.827 26.103 1.00 7.05 ? 194 ASN B N 1 ATOM 4364 C CA . ASN B 1 210 ? -36.033 -19.684 25.179 1.00 9.19 ? 194 ASN B CA 1 ATOM 4365 C C . ASN B 1 210 ? -36.614 -18.841 24.051 1.00 10.46 ? 194 ASN B C 1 ATOM 4366 O O . ASN B 1 210 ? -37.042 -19.367 23.024 1.00 19.42 ? 194 ASN B O 1 ATOM 4367 C CB . ASN B 1 210 ? -37.154 -20.432 25.900 1.00 19.82 ? 194 ASN B CB 1 ATOM 4368 C CG . ASN B 1 210 ? -36.639 -21.565 26.766 1.00 18.50 ? 194 ASN B CG 1 ATOM 4369 O OD1 . ASN B 1 210 ? -36.822 -21.565 27.983 1.00 25.06 ? 194 ASN B OD1 1 ATOM 4370 N ND2 . ASN B 1 210 ? -35.991 -22.541 26.139 1.00 18.66 ? 194 ASN B ND2 1 ATOM 4371 N N . GLU B 1 211 ? -36.628 -17.527 24.258 1.00 12.11 ? 195 GLU B N 1 ATOM 4372 C CA . GLU B 1 211 ? -37.163 -16.592 23.276 1.00 8.99 ? 195 GLU B CA 1 ATOM 4373 C C . GLU B 1 211 ? -36.089 -15.652 22.737 1.00 9.08 ? 195 GLU B C 1 ATOM 4374 O O . GLU B 1 211 ? -35.962 -15.474 21.526 1.00 8.68 ? 195 GLU B O 1 ATOM 4375 C CB . GLU B 1 211 ? -38.293 -15.774 23.904 1.00 12.93 ? 195 GLU B CB 1 ATOM 4376 C CG . GLU B 1 211 ? -38.811 -14.647 23.028 1.00 9.67 ? 195 GLU B CG 1 ATOM 4377 C CD . GLU B 1 211 ? -39.380 -15.143 21.714 1.00 10.95 ? 195 GLU B CD 1 ATOM 4378 O OE1 . GLU B 1 211 ? -39.573 -16.368 21.573 1.00 16.93 ? 195 GLU B OE1 1 ATOM 4379 O OE2 . GLU B 1 211 ? -39.636 -14.308 20.822 1.00 9.93 ? 195 GLU B OE2 1 ATOM 4380 N N . MET B 1 212 ? -35.323 -15.045 23.638 1.00 10.07 ? 196 MET B N 1 ATOM 4381 C CA . MET B 1 212 ? -34.307 -14.079 23.238 1.00 10.69 ? 196 MET B CA 1 ATOM 4382 C C . MET B 1 212 ? -33.035 -14.770 22.761 1.00 11.25 ? 196 MET B C 1 ATOM 4383 O O . MET B 1 212 ? -32.468 -15.610 23.461 1.00 18.14 ? 196 MET B O 1 ATOM 4384 C CB . MET B 1 212 ? -33.978 -13.133 24.395 1.00 10.42 ? 196 MET B CB 1 ATOM 4385 C CG . MET B 1 212 ? -35.159 -12.306 24.886 1.00 7.37 ? 196 MET B CG 1 ATOM 4386 S SD . MET B 1 212 ? -36.061 -11.496 23.554 1.00 5.19 ? 196 MET B SD 1 ATOM 4387 C CE . MET B 1 212 ? -34.781 -10.470 22.838 1.00 7.85 ? 196 MET B CE 1 ATOM 4388 N N . VAL B 1 213 ? -32.595 -14.405 21.561 1.00 10.38 ? 197 VAL B N 1 ATOM 4389 C CA . VAL B 1 213 ? -31.371 -14.944 20.981 1.00 10.11 ? 197 VAL B CA 1 ATOM 4390 C C . VAL B 1 213 ? -30.319 -13.845 20.850 1.00 8.18 ? 197 VAL B C 1 ATOM 4391 O O . VAL B 1 213 ? -30.648 -12.675 20.658 1.00 11.08 ? 197 VAL B O 1 ATOM 4392 C CB . VAL B 1 213 ? -31.644 -15.592 19.606 1.00 7.61 ? 197 VAL B CB 1 ATOM 4393 C CG1 . VAL B 1 213 ? -30.705 -15.041 18.541 1.00 6.62 ? 197 VAL B CG1 1 ATOM 4394 C CG2 . VAL B 1 213 ? -31.524 -17.103 19.708 1.00 15.44 ? 197 VAL B CG2 1 ATOM 4395 N N . LEU B 1 214 ? -29.054 -14.237 20.948 1.00 8.65 ? 198 LEU B N 1 ATOM 4396 C CA . LEU B 1 214 ? -27.943 -13.290 20.970 1.00 8.10 ? 198 LEU B CA 1 ATOM 4397 C C . LEU B 1 214 ? -27.311 -13.133 19.590 1.00 8.29 ? 198 LEU B C 1 ATOM 4398 O O . LEU B 1 214 ? -26.723 -14.070 19.054 1.00 7.08 ? 198 LEU B O 1 ATOM 4399 C CB . LEU B 1 214 ? -26.907 -13.746 22.003 1.00 8.72 ? 198 LEU B CB 1 ATOM 4400 C CG . LEU B 1 214 ? -25.440 -13.332 21.862 1.00 15.99 ? 198 LEU B CG 1 ATOM 4401 C CD1 . LEU B 1 214 ? -25.277 -11.856 21.527 1.00 22.51 ? 198 LEU B CD1 1 ATOM 4402 C CD2 . LEU B 1 214 ? -24.715 -13.654 23.160 1.00 8.19 ? 198 LEU B CD2 1 ATOM 4403 N N . LEU B 1 215 ? -27.435 -11.934 19.028 1.00 14.24 ? 199 LEU B N 1 ATOM 4404 C CA . LEU B 1 215 ? -26.961 -11.653 17.677 1.00 12.47 ? 199 LEU B CA 1 ATOM 4405 C C . LEU B 1 215 ? -25.665 -10.847 17.701 1.00 12.77 ? 199 LEU B C 1 ATOM 4406 O O . LEU B 1 215 ? -25.598 -9.789 18.326 1.00 16.14 ? 199 LEU B O 1 ATOM 4407 C CB . LEU B 1 215 ? -28.041 -10.889 16.903 1.00 14.16 ? 199 LEU B CB 1 ATOM 4408 C CG . LEU B 1 215 ? -27.834 -10.681 15.400 1.00 15.83 ? 199 LEU B CG 1 ATOM 4409 C CD1 . LEU B 1 215 ? -29.164 -10.364 14.735 1.00 7.46 ? 199 LEU B CD1 1 ATOM 4410 C CD2 . LEU B 1 215 ? -26.829 -9.573 15.113 1.00 18.00 ? 199 LEU B CD2 1 ATOM 4411 N N . THR B 1 216 ? -24.643 -11.352 17.013 1.00 16.91 ? 200 THR B N 1 ATOM 4412 C CA . THR B 1 216 ? -23.354 -10.676 16.931 1.00 14.84 ? 200 THR B CA 1 ATOM 4413 C C . THR B 1 216 ? -23.027 -10.302 15.490 1.00 13.29 ? 200 THR B C 1 ATOM 4414 O O . THR B 1 216 ? -22.874 -11.173 14.635 1.00 18.63 ? 200 THR B O 1 ATOM 4415 C CB . THR B 1 216 ? -22.217 -11.570 17.460 1.00 16.36 ? 200 THR B CB 1 ATOM 4416 O OG1 . THR B 1 216 ? -22.151 -12.774 16.684 1.00 25.55 ? 200 THR B OG1 1 ATOM 4417 C CG2 . THR B 1 216 ? -22.443 -11.926 18.918 1.00 15.58 ? 200 THR B CG2 1 ATOM 4418 N N . MET B 1 217 ? -22.907 -9.005 15.228 1.00 14.16 ? 201 MET B N 1 ATOM 4419 C CA . MET B 1 217 ? -22.520 -8.524 13.907 1.00 16.81 ? 201 MET B CA 1 ATOM 4420 C C . MET B 1 217 ? -21.297 -7.627 14.029 1.00 18.95 ? 201 MET B C 1 ATOM 4421 O O . MET B 1 217 ? -21.274 -6.700 14.838 1.00 24.23 ? 201 MET B O 1 ATOM 4422 C CB . MET B 1 217 ? -23.664 -7.747 13.252 1.00 20.36 ? 201 MET B CB 1 ATOM 4423 C CG . MET B 1 217 ? -23.493 -7.533 11.750 1.00 16.98 ? 201 MET B CG 1 ATOM 4424 S SD . MET B 1 217 ? -24.779 -6.491 11.041 1.00 16.69 ? 201 MET B SD 1 ATOM 4425 C CE . MET B 1 217 ? -24.615 -5.019 12.048 1.00 21.51 ? 201 MET B CE 1 ATOM 4426 N N . LYS B 1 218 ? -20.284 -7.914 13.219 1.00 23.14 ? 202 LYS B N 1 ATOM 4427 C CA . LYS B 1 218 ? -19.028 -7.171 13.248 1.00 29.55 ? 202 LYS B CA 1 ATOM 4428 C C . LYS B 1 218 ? -18.393 -7.208 14.637 1.00 28.91 ? 202 LYS B C 1 ATOM 4429 O O . LYS B 1 218 ? -17.745 -8.190 15.001 1.00 36.78 ? 202 LYS B O 1 ATOM 4430 C CB . LYS B 1 218 ? -19.231 -5.721 12.789 1.00 29.22 ? 202 LYS B CB 1 ATOM 4431 C CG . LYS B 1 218 ? -18.959 -5.486 11.314 1.00 22.81 ? 202 LYS B CG 1 ATOM 4432 C CD . LYS B 1 218 ? -17.506 -5.776 10.971 1.00 18.32 ? 202 LYS B CD 1 ATOM 4433 C CE . LYS B 1 218 ? -17.025 -4.931 9.801 1.00 24.06 ? 202 LYS B CE 1 ATOM 4434 N NZ . LYS B 1 218 ? -16.765 -3.518 10.202 1.00 31.14 ? 202 LYS B NZ 1 ATOM 4435 N N . GLU B 1 219 ? -18.581 -6.140 15.407 1.00 24.51 ? 203 GLU B N 1 ATOM 4436 C CA . GLU B 1 219 ? -17.902 -5.995 16.687 1.00 25.33 ? 203 GLU B CA 1 ATOM 4437 C C . GLU B 1 219 ? -18.877 -5.553 17.772 1.00 32.44 ? 203 GLU B C 1 ATOM 4438 O O . GLU B 1 219 ? -18.475 -4.978 18.783 1.00 38.06 ? 203 GLU B O 1 ATOM 4439 C CB . GLU B 1 219 ? -16.771 -4.973 16.559 1.00 30.92 ? 203 GLU B CB 1 ATOM 4440 C CG . GLU B 1 219 ? -15.907 -5.150 15.313 1.00 28.92 ? 203 GLU B CG 1 ATOM 4441 C CD . GLU B 1 219 ? -15.126 -3.899 14.962 1.00 23.95 ? 203 GLU B CD 1 ATOM 4442 O OE1 . GLU B 1 219 ? -14.789 -3.722 13.773 1.00 27.94 ? 203 GLU B OE1 1 ATOM 4443 O OE2 . GLU B 1 219 ? -14.853 -3.092 15.873 1.00 29.85 ? 203 GLU B OE2 1 ATOM 4444 N N . LYS B 1 220 ? -20.160 -5.824 17.557 1.00 32.68 ? 204 LYS B N 1 ATOM 4445 C CA . LYS B 1 220 ? -21.195 -5.453 18.514 1.00 23.45 ? 204 LYS B CA 1 ATOM 4446 C C . LYS B 1 220 ? -22.191 -6.592 18.672 1.00 18.48 ? 204 LYS B C 1 ATOM 4447 O O . LYS B 1 220 ? -22.151 -7.567 17.923 1.00 18.05 ? 204 LYS B O 1 ATOM 4448 C CB . LYS B 1 220 ? -21.911 -4.180 18.059 1.00 26.62 ? 204 LYS B CB 1 ATOM 4449 C CG . LYS B 1 220 ? -21.005 -2.962 17.986 1.00 27.64 ? 204 LYS B CG 1 ATOM 4450 C CD . LYS B 1 220 ? -21.781 -1.704 17.641 1.00 30.76 ? 204 LYS B CD 1 ATOM 4451 C CE . LYS B 1 220 ? -21.156 -0.476 18.284 1.00 45.99 ? 204 LYS B CE 1 ATOM 4452 N NZ . LYS B 1 220 ? -21.593 -0.317 19.698 1.00 49.30 ? 204 LYS B NZ 1 ATOM 4453 N N . SER B 1 221 ? -23.081 -6.469 19.651 1.00 21.75 ? 205 SER B N 1 ATOM 4454 C CA . SER B 1 221 ? -24.033 -7.533 19.948 1.00 14.98 ? 205 SER B CA 1 ATOM 4455 C C . SER B 1 221 ? -25.396 -6.988 20.361 1.00 12.56 ? 205 SER B C 1 ATOM 4456 O O . SER B 1 221 ? -25.516 -5.836 20.780 1.00 18.08 ? 205 SER B O 1 ATOM 4457 C CB . SER B 1 221 ? -23.481 -8.436 21.049 1.00 17.69 ? 205 SER B CB 1 ATOM 4458 O OG . SER B 1 221 ? -22.302 -9.090 20.619 1.00 23.55 ? 205 SER B OG 1 ATOM 4459 N N . TRP B 1 222 ? -26.416 -7.832 20.238 1.00 11.99 ? 206 TRP B N 1 ATOM 4460 C CA . TRP B 1 222 ? -27.786 -7.454 20.562 1.00 9.83 ? 206 TRP B CA 1 ATOM 4461 C C . TRP B 1 222 ? -28.578 -8.643 21.094 1.00 9.87 ? 206 TRP B C 1 ATOM 4462 O O . TRP B 1 222 ? -28.212 -9.796 20.865 1.00 9.68 ? 206 TRP B O 1 ATOM 4463 C CB . TRP B 1 222 ? -28.496 -6.928 19.313 1.00 10.83 ? 206 TRP B CB 1 ATOM 4464 C CG . TRP B 1 222 ? -28.064 -5.567 18.874 1.00 11.43 ? 206 TRP B CG 1 ATOM 4465 C CD1 . TRP B 1 222 ? -28.643 -4.379 19.209 1.00 11.78 ? 206 TRP B CD1 1 ATOM 4466 C CD2 . TRP B 1 222 ? -26.968 -5.250 18.007 1.00 12.70 ? 206 TRP B CD2 1 ATOM 4467 N NE1 . TRP B 1 222 ? -27.975 -3.341 18.608 1.00 16.08 ? 206 TRP B NE1 1 ATOM 4468 C CE2 . TRP B 1 222 ? -26.942 -3.848 17.866 1.00 14.49 ? 206 TRP B CE2 1 ATOM 4469 C CE3 . TRP B 1 222 ? -26.006 -6.014 17.339 1.00 18.15 ? 206 TRP B CE3 1 ATOM 4470 C CZ2 . TRP B 1 222 ? -25.991 -3.195 17.084 1.00 17.07 ? 206 TRP B CZ2 1 ATOM 4471 C CZ3 . TRP B 1 222 ? -25.062 -5.362 16.564 1.00 17.97 ? 206 TRP B CZ3 1 ATOM 4472 C CH2 . TRP B 1 222 ? -25.062 -3.967 16.444 1.00 13.36 ? 206 TRP B CH2 1 ATOM 4473 N N . LEU B 1 223 ? -29.664 -8.354 21.805 1.00 12.06 ? 207 LEU B N 1 ATOM 4474 C CA . LEU B 1 223 ? -30.686 -9.356 22.086 1.00 8.50 ? 207 LEU B CA 1 ATOM 4475 C C . LEU B 1 223 ? -31.790 -9.194 21.052 1.00 6.80 ? 207 LEU B C 1 ATOM 4476 O O . LEU B 1 223 ? -32.214 -8.076 20.761 1.00 7.32 ? 207 LEU B O 1 ATOM 4477 C CB . LEU B 1 223 ? -31.278 -9.186 23.488 1.00 17.19 ? 207 LEU B CB 1 ATOM 4478 C CG . LEU B 1 223 ? -30.443 -9.589 24.709 1.00 16.71 ? 207 LEU B CG 1 ATOM 4479 C CD1 . LEU B 1 223 ? -29.378 -10.616 24.350 1.00 11.48 ? 207 LEU B CD1 1 ATOM 4480 C CD2 . LEU B 1 223 ? -29.826 -8.365 25.369 1.00 17.31 ? 207 LEU B CD2 1 ATOM 4481 N N . VAL B 1 224 ? -32.250 -10.306 20.493 1.00 7.41 ? 208 VAL B N 1 ATOM 4482 C CA . VAL B 1 224 ? -33.307 -10.271 19.491 1.00 5.00 ? 208 VAL B CA 1 ATOM 4483 C C . VAL B 1 224 ? -34.252 -11.445 19.693 1.00 7.12 ? 208 VAL B C 1 ATOM 4484 O O . VAL B 1 224 ? -33.900 -12.430 20.337 1.00 11.22 ? 208 VAL B O 1 ATOM 4485 C CB . VAL B 1 224 ? -32.733 -10.328 18.061 1.00 8.79 ? 208 VAL B CB 1 ATOM 4486 C CG1 . VAL B 1 224 ? -31.785 -9.162 17.823 1.00 7.96 ? 208 VAL B CG1 1 ATOM 4487 C CG2 . VAL B 1 224 ? -32.021 -11.650 17.823 1.00 6.40 ? 208 VAL B CG2 1 ATOM 4488 N N . HIS B 1 225 ? -35.455 -11.336 19.144 1.00 6.36 ? 209 HIS B N 1 ATOM 4489 C CA . HIS B 1 225 ? -36.427 -12.417 19.241 1.00 4.70 ? 209 HIS B CA 1 ATOM 4490 C C . HIS B 1 225 ? -36.060 -13.533 18.272 1.00 5.70 ? 209 HIS B C 1 ATOM 4491 O O . HIS B 1 225 ? -35.613 -13.276 17.155 1.00 8.00 ? 209 HIS B O 1 ATOM 4492 C CB . HIS B 1 225 ? -37.839 -11.897 18.967 1.00 6.42 ? 209 HIS B CB 1 ATOM 4493 C CG . HIS B 1 225 ? -38.397 -11.064 20.077 1.00 5.75 ? 209 HIS B CG 1 ATOM 4494 N ND1 . HIS B 1 225 ? -39.328 -11.546 20.972 1.00 3.33 ? 209 HIS B ND1 1 ATOM 4495 C CD2 . HIS B 1 225 ? -38.150 -9.783 20.447 1.00 9.69 ? 209 HIS B CD2 1 ATOM 4496 C CE1 . HIS B 1 225 ? -39.634 -10.597 21.842 1.00 7.13 ? 209 HIS B CE1 1 ATOM 4497 N NE2 . HIS B 1 225 ? -38.932 -9.520 21.542 1.00 8.26 ? 209 HIS B NE2 1 ATOM 4498 N N . LYS B 1 226 ? -36.245 -14.773 18.713 1.00 5.33 ? 210 LYS B N 1 ATOM 4499 C CA . LYS B 1 226 ? -35.800 -15.934 17.954 1.00 4.53 ? 210 LYS B CA 1 ATOM 4500 C C . LYS B 1 226 ? -36.444 -15.993 16.574 1.00 6.84 ? 210 LYS B C 1 ATOM 4501 O O . LYS B 1 226 ? -35.764 -16.228 15.576 1.00 7.95 ? 210 LYS B O 1 ATOM 4502 C CB . LYS B 1 226 ? -36.103 -17.218 18.725 1.00 7.43 ? 210 LYS B CB 1 ATOM 4503 C CG . LYS B 1 226 ? -35.469 -18.462 18.122 1.00 9.84 ? 210 LYS B CG 1 ATOM 4504 C CD . LYS B 1 226 ? -35.780 -19.709 18.936 1.00 4.36 ? 210 LYS B CD 1 ATOM 4505 C CE . LYS B 1 226 ? -35.326 -19.561 20.378 1.00 11.66 ? 210 LYS B CE 1 ATOM 4506 N NZ . LYS B 1 226 ? -35.440 -20.839 21.133 1.00 18.92 ? 210 LYS B NZ 1 ATOM 4507 N N . GLN B 1 227 ? -37.753 -15.779 16.516 1.00 6.49 ? 211 GLN B N 1 ATOM 4508 C CA . GLN B 1 227 ? -38.466 -15.869 15.250 1.00 7.52 ? 211 GLN B CA 1 ATOM 4509 C C . GLN B 1 227 ? -38.102 -14.697 14.347 1.00 7.18 ? 211 GLN B C 1 ATOM 4510 O O . GLN B 1 227 ? -37.927 -14.865 13.140 1.00 10.69 ? 211 GLN B O 1 ATOM 4511 C CB . GLN B 1 227 ? -39.977 -15.912 15.475 1.00 10.48 ? 211 GLN B CB 1 ATOM 4512 C CG . GLN B 1 227 ? -40.735 -16.562 14.330 1.00 6.10 ? 211 GLN B CG 1 ATOM 4513 C CD . GLN B 1 227 ? -40.270 -17.981 14.062 1.00 8.27 ? 211 GLN B CD 1 ATOM 4514 O OE1 . GLN B 1 227 ? -40.196 -18.805 14.974 1.00 12.92 ? 211 GLN B OE1 1 ATOM 4515 N NE2 . GLN B 1 227 ? -39.940 -18.269 12.809 1.00 11.73 ? 211 GLN B NE2 1 ATOM 4516 N N . TRP B 1 228 ? -37.987 -13.511 14.935 1.00 6.88 ? 212 TRP B N 1 ATOM 4517 C CA . TRP B 1 228 ? -37.560 -12.342 14.185 1.00 7.59 ? 212 TRP B CA 1 ATOM 4518 C C . TRP B 1 228 ? -36.250 -12.638 13.469 1.00 8.14 ? 212 TRP B C 1 ATOM 4519 O O . TRP B 1 228 ? -36.043 -12.221 12.331 1.00 11.14 ? 212 TRP B O 1 ATOM 4520 C CB . TRP B 1 228 ? -37.379 -11.144 15.113 1.00 6.63 ? 212 TRP B CB 1 ATOM 4521 C CG . TRP B 1 228 ? -36.957 -9.914 14.392 1.00 6.45 ? 212 TRP B CG 1 ATOM 4522 C CD1 . TRP B 1 228 ? -37.770 -9.008 13.783 1.00 4.25 ? 212 TRP B CD1 1 ATOM 4523 C CD2 . TRP B 1 228 ? -35.617 -9.450 14.194 1.00 6.83 ? 212 TRP B CD2 1 ATOM 4524 N NE1 . TRP B 1 228 ? -37.022 -8.007 13.217 1.00 3.58 ? 212 TRP B NE1 1 ATOM 4525 C CE2 . TRP B 1 228 ? -35.696 -8.254 13.455 1.00 4.83 ? 212 TRP B CE2 1 ATOM 4526 C CE3 . TRP B 1 228 ? -34.358 -9.929 14.570 1.00 6.70 ? 212 TRP B CE3 1 ATOM 4527 C CZ2 . TRP B 1 228 ? -34.566 -7.529 13.086 1.00 5.23 ? 212 TRP B CZ2 1 ATOM 4528 C CZ3 . TRP B 1 228 ? -33.237 -9.209 14.201 1.00 7.49 ? 212 TRP B CZ3 1 ATOM 4529 C CH2 . TRP B 1 228 ? -33.349 -8.020 13.468 1.00 8.79 ? 212 TRP B CH2 1 ATOM 4530 N N . PHE B 1 229 ? -35.369 -13.364 14.147 1.00 9.09 ? 213 PHE B N 1 ATOM 4531 C CA . PHE B 1 229 ? -34.073 -13.721 13.587 1.00 8.16 ? 213 PHE B CA 1 ATOM 4532 C C . PHE B 1 229 ? -34.190 -14.843 12.560 1.00 5.62 ? 213 PHE B C 1 ATOM 4533 O O . PHE B 1 229 ? -33.472 -14.856 11.561 1.00 4.65 ? 213 PHE B O 1 ATOM 4534 C CB . PHE B 1 229 ? -33.118 -14.139 14.706 1.00 6.65 ? 213 PHE B CB 1 ATOM 4535 C CG . PHE B 1 229 ? -31.881 -14.829 14.217 1.00 6.99 ? 213 PHE B CG 1 ATOM 4536 C CD1 . PHE B 1 229 ? -30.830 -14.103 13.685 1.00 6.29 ? 213 PHE B CD1 1 ATOM 4537 C CD2 . PHE B 1 229 ? -31.768 -16.206 14.294 1.00 5.19 ? 213 PHE B CD2 1 ATOM 4538 C CE1 . PHE B 1 229 ? -29.690 -14.739 13.235 1.00 4.79 ? 213 PHE B CE1 1 ATOM 4539 C CE2 . PHE B 1 229 ? -30.632 -16.847 13.847 1.00 4.86 ? 213 PHE B CE2 1 ATOM 4540 C CZ . PHE B 1 229 ? -29.592 -16.113 13.315 1.00 8.90 ? 213 PHE B CZ 1 ATOM 4541 N N . LEU B 1 230 ? -35.097 -15.782 12.808 1.00 6.03 ? 214 LEU B N 1 ATOM 4542 C CA . LEU B 1 230 ? -35.266 -16.935 11.930 1.00 5.24 ? 214 LEU B CA 1 ATOM 4543 C C . LEU B 1 230 ? -36.029 -16.584 10.652 1.00 7.03 ? 214 LEU B C 1 ATOM 4544 O O . LEU B 1 230 ? -36.024 -17.356 9.692 1.00 7.17 ? 214 LEU B O 1 ATOM 4545 C CB . LEU B 1 230 ? -35.984 -18.065 12.675 1.00 4.92 ? 214 LEU B CB 1 ATOM 4546 C CG . LEU B 1 230 ? -35.193 -18.769 13.781 1.00 3.41 ? 214 LEU B CG 1 ATOM 4547 C CD1 . LEU B 1 230 ? -36.078 -19.764 14.513 1.00 2.57 ? 214 LEU B CD1 1 ATOM 4548 C CD2 . LEU B 1 230 ? -33.972 -19.467 13.212 1.00 8.68 ? 214 LEU B CD2 1 ATOM 4549 N N . ASP B 1 231 ? -36.677 -15.422 10.638 1.00 9.72 ? 215 ASP B N 1 ATOM 4550 C CA . ASP B 1 231 ? -37.458 -15.002 9.476 1.00 6.89 ? 215 ASP B CA 1 ATOM 4551 C C . ASP B 1 231 ? -36.851 -13.805 8.746 1.00 7.77 ? 215 ASP B C 1 ATOM 4552 O O . ASP B 1 231 ? -37.509 -13.182 7.913 1.00 16.13 ? 215 ASP B O 1 ATOM 4553 C CB . ASP B 1 231 ? -38.900 -14.694 9.889 1.00 8.00 ? 215 ASP B CB 1 ATOM 4554 C CG . ASP B 1 231 ? -39.734 -15.948 10.067 1.00 12.49 ? 215 ASP B CG 1 ATOM 4555 O OD1 . ASP B 1 231 ? -39.352 -17.001 9.514 1.00 12.91 ? 215 ASP B OD1 1 ATOM 4556 O OD2 . ASP B 1 231 ? -40.774 -15.882 10.754 1.00 16.83 ? 215 ASP B OD2 1 ATOM 4557 N N . LEU B 1 232 ? -35.596 -13.491 9.046 1.00 10.74 ? 216 LEU B N 1 ATOM 4558 C CA . LEU B 1 232 ? -34.895 -12.428 8.336 1.00 10.70 ? 216 LEU B CA 1 ATOM 4559 C C . LEU B 1 232 ? -34.569 -12.893 6.923 1.00 16.22 ? 216 LEU B C 1 ATOM 4560 O O . LEU B 1 232 ? -34.026 -13.980 6.735 1.00 16.10 ? 216 LEU B O 1 ATOM 4561 C CB . LEU B 1 232 ? -33.609 -12.041 9.069 1.00 12.15 ? 216 LEU B CB 1 ATOM 4562 C CG . LEU B 1 232 ? -33.757 -11.033 10.211 1.00 6.95 ? 216 LEU B CG 1 ATOM 4563 C CD1 . LEU B 1 232 ? -32.455 -10.906 10.981 1.00 5.75 ? 216 LEU B CD1 1 ATOM 4564 C CD2 . LEU B 1 232 ? -34.192 -9.679 9.676 1.00 8.16 ? 216 LEU B CD2 1 ATOM 4565 N N . PRO B 1 233 ? -34.901 -12.067 5.919 1.00 15.59 ? 217 PRO B N 1 ATOM 4566 C CA . PRO B 1 233 ? -34.670 -12.436 4.519 1.00 14.58 ? 217 PRO B CA 1 ATOM 4567 C C . PRO B 1 233 ? -33.207 -12.288 4.109 1.00 19.21 ? 217 PRO B C 1 ATOM 4568 O O . PRO B 1 233 ? -32.866 -11.389 3.338 1.00 17.09 ? 217 PRO B O 1 ATOM 4569 C CB . PRO B 1 233 ? -35.550 -11.445 3.755 1.00 12.77 ? 217 PRO B CB 1 ATOM 4570 C CG . PRO B 1 233 ? -35.583 -10.245 4.620 1.00 14.61 ? 217 PRO B CG 1 ATOM 4571 C CD . PRO B 1 233 ? -35.542 -10.746 6.039 1.00 14.92 ? 217 PRO B CD 1 ATOM 4572 N N . LEU B 1 234 ? -32.354 -13.165 4.629 1.00 14.69 ? 218 LEU B N 1 ATOM 4573 C CA . LEU B 1 234 ? -30.942 -13.172 4.269 1.00 11.10 ? 218 LEU B CA 1 ATOM 4574 C C . LEU B 1 234 ? -30.466 -14.599 4.024 1.00 14.70 ? 218 LEU B C 1 ATOM 4575 O O . LEU B 1 234 ? -31.043 -15.547 4.556 1.00 16.37 ? 218 LEU B O 1 ATOM 4576 C CB . LEU B 1 234 ? -30.103 -12.538 5.381 1.00 11.53 ? 218 LEU B CB 1 ATOM 4577 C CG . LEU B 1 234 ? -30.256 -11.031 5.589 1.00 11.74 ? 218 LEU B CG 1 ATOM 4578 C CD1 . LEU B 1 234 ? -29.545 -10.603 6.860 1.00 13.02 ? 218 LEU B CD1 1 ATOM 4579 C CD2 . LEU B 1 234 ? -29.711 -10.267 4.396 1.00 14.97 ? 218 LEU B CD2 1 ATOM 4580 N N . PRO B 1 235 ? -29.410 -14.759 3.210 1.00 14.20 ? 219 PRO B N 1 ATOM 4581 C CA . PRO B 1 235 ? -28.829 -16.088 2.993 1.00 11.72 ? 219 PRO B CA 1 ATOM 4582 C C . PRO B 1 235 ? -28.341 -16.685 4.310 1.00 13.36 ? 219 PRO B C 1 ATOM 4583 O O . PRO B 1 235 ? -27.690 -15.977 5.077 1.00 17.35 ? 219 PRO B O 1 ATOM 4584 C CB . PRO B 1 235 ? -27.644 -15.809 2.062 1.00 11.54 ? 219 PRO B CB 1 ATOM 4585 C CG . PRO B 1 235 ? -27.948 -14.499 1.421 1.00 11.03 ? 219 PRO B CG 1 ATOM 4586 C CD . PRO B 1 235 ? -28.715 -13.716 2.436 1.00 10.76 ? 219 PRO B CD 1 ATOM 4587 N N . TRP B 1 236 ? -28.641 -17.954 4.571 1.00 11.89 ? 220 TRP B N 1 ATOM 4588 C CA . TRP B 1 236 ? -28.322 -18.542 5.868 1.00 9.07 ? 220 TRP B CA 1 ATOM 4589 C C . TRP B 1 236 ? -27.705 -19.933 5.767 1.00 9.92 ? 220 TRP B C 1 ATOM 4590 O O . TRP B 1 236 ? -27.890 -20.643 4.779 1.00 12.61 ? 220 TRP B O 1 ATOM 4591 C CB . TRP B 1 236 ? -29.579 -18.610 6.738 1.00 13.31 ? 220 TRP B CB 1 ATOM 4592 C CG . TRP B 1 236 ? -30.587 -19.616 6.263 1.00 12.14 ? 220 TRP B CG 1 ATOM 4593 C CD1 . TRP B 1 236 ? -31.557 -19.424 5.323 1.00 9.66 ? 220 TRP B CD1 1 ATOM 4594 C CD2 . TRP B 1 236 ? -30.723 -20.971 6.708 1.00 10.20 ? 220 TRP B CD2 1 ATOM 4595 N NE1 . TRP B 1 236 ? -32.288 -20.576 5.154 1.00 10.45 ? 220 TRP B NE1 1 ATOM 4596 C CE2 . TRP B 1 236 ? -31.795 -21.541 5.993 1.00 9.10 ? 220 TRP B CE2 1 ATOM 4597 C CE3 . TRP B 1 236 ? -30.041 -21.759 7.642 1.00 9.20 ? 220 TRP B CE3 1 ATOM 4598 C CZ2 . TRP B 1 236 ? -32.203 -22.860 6.183 1.00 10.86 ? 220 TRP B CZ2 1 ATOM 4599 C CZ3 . TRP B 1 236 ? -30.446 -23.067 7.828 1.00 6.98 ? 220 TRP B CZ3 1 ATOM 4600 C CH2 . TRP B 1 236 ? -31.516 -23.604 7.103 1.00 13.22 ? 220 TRP B CH2 1 ATOM 4601 N N . THR B 1 237 ? -26.973 -20.313 6.809 1.00 12.75 ? 221 THR B N 1 ATOM 4602 C CA . THR B 1 237 ? -26.405 -21.650 6.913 1.00 9.51 ? 221 THR B CA 1 ATOM 4603 C C . THR B 1 237 ? -26.459 -22.092 8.368 1.00 10.15 ? 221 THR B C 1 ATOM 4604 O O . THR B 1 237 ? -26.318 -21.276 9.279 1.00 13.51 ? 221 THR B O 1 ATOM 4605 C CB . THR B 1 237 ? -24.948 -21.695 6.415 1.00 14.11 ? 221 THR B CB 1 ATOM 4606 O OG1 . THR B 1 237 ? -24.451 -23.037 6.496 1.00 22.68 ? 221 THR B OG1 1 ATOM 4607 C CG2 . THR B 1 237 ? -24.064 -20.776 7.244 1.00 11.40 ? 221 THR B CG2 1 ATOM 4608 N N . SER B 1 238 ? -26.676 -23.384 8.584 1.00 11.61 ? 222 SER B N 1 ATOM 4609 C CA . SER B 1 238 ? -26.818 -23.913 9.934 1.00 6.93 ? 222 SER B CA 1 ATOM 4610 C C . SER B 1 238 ? -25.578 -23.632 10.776 1.00 8.89 ? 222 SER B C 1 ATOM 4611 O O . SER B 1 238 ? -24.472 -23.514 10.249 1.00 11.71 ? 222 SER B O 1 ATOM 4612 C CB . SER B 1 238 ? -27.077 -25.417 9.888 1.00 7.68 ? 222 SER B CB 1 ATOM 4613 O OG . SER B 1 238 ? -27.139 -25.957 11.198 1.00 16.96 ? 222 SER B OG 1 ATOM 4614 N N . GLY B 1 239 ? -25.774 -23.520 12.087 1.00 6.44 ? 223 GLY B N 1 ATOM 4615 C CA . GLY B 1 239 ? -24.671 -23.343 13.013 1.00 4.16 ? 223 GLY B CA 1 ATOM 4616 C C . GLY B 1 239 ? -23.997 -24.660 13.335 1.00 9.40 ? 223 GLY B C 1 ATOM 4617 O O . GLY B 1 239 ? -23.033 -24.705 14.100 1.00 8.10 ? 223 GLY B O 1 ATOM 4618 N N . ALA B 1 240 ? -24.507 -25.737 12.746 1.00 14.88 ? 224 ALA B N 1 ATOM 4619 C CA . ALA B 1 240 ? -23.970 -27.068 12.981 1.00 9.49 ? 224 ALA B CA 1 ATOM 4620 C C . ALA B 1 240 ? -22.576 -27.208 12.379 1.00 10.98 ? 224 ALA B C 1 ATOM 4621 O O . ALA B 1 240 ? -22.323 -26.791 11.248 1.00 14.65 ? 224 ALA B O 1 ATOM 4622 C CB . ALA B 1 240 ? -24.910 -28.117 12.411 1.00 8.94 ? 224 ALA B CB 1 ATOM 4623 N N . SER B 1 241 ? -21.675 -27.801 13.156 1.00 14.67 ? 225 SER B N 1 ATOM 4624 C CA . SER B 1 241 ? -20.287 -27.980 12.748 1.00 17.10 ? 225 SER B CA 1 ATOM 4625 C C . SER B 1 241 ? -20.161 -28.631 11.377 1.00 19.58 ? 225 SER B C 1 ATOM 4626 O O . SER B 1 241 ? -20.933 -29.521 11.020 1.00 16.74 ? 225 SER B O 1 ATOM 4627 C CB . SER B 1 241 ? -19.546 -28.823 13.784 1.00 10.39 ? 225 SER B CB 1 ATOM 4628 O OG . SER B 1 241 ? -20.280 -29.991 14.106 1.00 16.79 ? 225 SER B OG 1 ATOM 4629 N N . THR B 1 242 ? -19.171 -28.173 10.621 1.00 18.84 ? 226 THR B N 1 ATOM 4630 C CA . THR B 1 242 ? -18.914 -28.673 9.277 1.00 19.34 ? 226 THR B CA 1 ATOM 4631 C C . THR B 1 242 ? -17.620 -28.063 8.753 1.00 25.35 ? 226 THR B C 1 ATOM 4632 O O . THR B 1 242 ? -17.078 -27.135 9.352 1.00 23.22 ? 226 THR B O 1 ATOM 4633 C CB . THR B 1 242 ? -20.061 -28.316 8.316 1.00 20.75 ? 226 THR B CB 1 ATOM 4634 O OG1 . THR B 1 242 ? -19.757 -28.799 7.002 1.00 31.41 ? 226 THR B OG1 1 ATOM 4635 C CG2 . THR B 1 242 ? -20.267 -26.809 8.266 1.00 21.89 ? 226 THR B CG2 1 ATOM 4636 N N . SER B 1 243 ? -17.130 -28.582 7.632 1.00 30.28 ? 227 SER B N 1 ATOM 4637 C CA . SER B 1 243 ? -15.892 -28.084 7.042 1.00 28.18 ? 227 SER B CA 1 ATOM 4638 C C . SER B 1 243 ? -16.066 -26.676 6.482 1.00 34.69 ? 227 SER B C 1 ATOM 4639 O O . SER B 1 243 ? -15.599 -25.703 7.075 1.00 38.39 ? 227 SER B O 1 ATOM 4640 C CB . SER B 1 243 ? -15.406 -29.024 5.937 1.00 22.86 ? 227 SER B CB 1 ATOM 4641 O OG . SER B 1 243 ? -16.422 -29.258 4.979 1.00 28.78 ? 227 SER B OG 1 ATOM 4642 N N . GLN B 1 244 ? -16.739 -26.574 5.340 1.00 28.90 ? 228 GLN B N 1 ATOM 4643 C CA . GLN B 1 244 ? -16.871 -25.299 4.644 1.00 34.23 ? 228 GLN B CA 1 ATOM 4644 C C . GLN B 1 244 ? -18.279 -24.723 4.750 1.00 27.79 ? 228 GLN B C 1 ATOM 4645 O O . GLN B 1 244 ? -19.228 -25.422 5.107 1.00 21.61 ? 228 GLN B O 1 ATOM 4646 C CB . GLN B 1 244 ? -16.505 -25.464 3.168 1.00 32.93 ? 228 GLN B CB 1 ATOM 4647 C CG . GLN B 1 244 ? -17.423 -26.411 2.409 1.00 31.94 ? 228 GLN B CG 1 ATOM 4648 C CD . GLN B 1 244 ? -17.236 -26.327 0.909 1.00 26.17 ? 228 GLN B CD 1 ATOM 4649 O OE1 . GLN B 1 244 ? -16.246 -25.777 0.424 1.00 31.62 ? 228 GLN B OE1 1 ATOM 4650 N NE2 . GLN B 1 244 ? -18.192 -26.869 0.164 1.00 20.18 ? 228 GLN B NE2 1 ATOM 4651 N N . GLU B 1 245 ? -18.399 -23.439 4.431 1.00 34.34 ? 229 GLU B N 1 ATOM 4652 C CA . GLU B 1 245 ? -19.688 -22.762 4.418 1.00 33.58 ? 229 GLU B CA 1 ATOM 4653 C C . GLU B 1 245 ? -20.596 -23.311 3.322 1.00 29.29 ? 229 GLU B C 1 ATOM 4654 O O . GLU B 1 245 ? -20.188 -23.436 2.168 1.00 29.81 ? 229 GLU B O 1 ATOM 4655 C CB . GLU B 1 245 ? -19.492 -21.259 4.211 1.00 34.79 ? 229 GLU B CB 1 ATOM 4656 C CG . GLU B 1 245 ? -18.901 -20.527 5.407 1.00 28.09 ? 229 GLU B CG 1 ATOM 4657 C CD . GLU B 1 245 ? -18.557 -19.083 5.090 1.00 27.66 ? 229 GLU B CD 1 ATOM 4658 O OE1 . GLU B 1 245 ? -18.356 -18.294 6.037 1.00 27.09 ? 229 GLU B OE1 1 ATOM 4659 O OE2 . GLU B 1 245 ? -18.487 -18.738 3.891 1.00 28.13 ? 229 GLU B OE2 1 ATOM 4660 N N . THR B 1 246 ? -21.829 -23.638 3.698 1.00 28.43 ? 230 THR B N 1 ATOM 4661 C CA . THR B 1 246 ? -22.843 -24.080 2.746 1.00 20.90 ? 230 THR B CA 1 ATOM 4662 C C . THR B 1 246 ? -24.106 -23.256 2.964 1.00 22.24 ? 230 THR B C 1 ATOM 4663 O O . THR B 1 246 ? -24.841 -23.470 3.928 1.00 21.49 ? 230 THR B O 1 ATOM 4664 C CB . THR B 1 246 ? -23.167 -25.578 2.907 1.00 25.78 ? 230 THR B CB 1 ATOM 4665 O OG1 . THR B 1 246 ? -24.559 -25.745 3.204 1.00 32.78 ? 230 THR B OG1 1 ATOM 4666 C CG2 . THR B 1 246 ? -22.331 -26.193 4.021 1.00 27.68 ? 230 THR B CG2 1 ATOM 4667 N N . TRP B 1 247 ? -24.354 -22.315 2.060 1.00 24.24 ? 231 TRP B N 1 ATOM 4668 C CA . TRP B 1 247 ? -25.395 -21.314 2.263 1.00 15.51 ? 231 TRP B CA 1 ATOM 4669 C C . TRP B 1 247 ? -26.735 -21.695 1.649 1.00 16.00 ? 231 TRP B C 1 ATOM 4670 O O . TRP B 1 247 ? -26.806 -22.467 0.692 1.00 18.35 ? 231 TRP B O 1 ATOM 4671 C CB . TRP B 1 247 ? -24.939 -19.967 1.700 1.00 12.42 ? 231 TRP B CB 1 ATOM 4672 C CG . TRP B 1 247 ? -23.743 -19.414 2.404 1.00 14.42 ? 231 TRP B CG 1 ATOM 4673 C CD1 . TRP B 1 247 ? -22.437 -19.552 2.035 1.00 18.66 ? 231 TRP B CD1 1 ATOM 4674 C CD2 . TRP B 1 247 ? -23.740 -18.640 3.609 1.00 12.90 ? 231 TRP B CD2 1 ATOM 4675 N NE1 . TRP B 1 247 ? -21.621 -18.909 2.934 1.00 15.99 ? 231 TRP B NE1 1 ATOM 4676 C CE2 . TRP B 1 247 ? -22.397 -18.341 3.910 1.00 15.81 ? 231 TRP B CE2 1 ATOM 4677 C CE3 . TRP B 1 247 ? -24.743 -18.170 4.461 1.00 12.66 ? 231 TRP B CE3 1 ATOM 4678 C CZ2 . TRP B 1 247 ? -22.031 -17.595 5.027 1.00 16.18 ? 231 TRP B CZ2 1 ATOM 4679 C CZ3 . TRP B 1 247 ? -24.378 -17.429 5.569 1.00 13.52 ? 231 TRP B CZ3 1 ATOM 4680 C CH2 . TRP B 1 247 ? -23.034 -17.150 5.843 1.00 10.86 ? 231 TRP B CH2 1 ATOM 4681 N N . ASN B 1 248 ? -27.796 -21.134 2.220 1.00 11.80 ? 232 ASN B N 1 ATOM 4682 C CA . ASN B 1 248 ? -29.143 -21.287 1.697 1.00 8.39 ? 232 ASN B CA 1 ATOM 4683 C C . ASN B 1 248 ? -29.686 -19.920 1.316 1.00 13.58 ? 232 ASN B C 1 ATOM 4684 O O . ASN B 1 248 ? -29.343 -18.916 1.938 1.00 15.54 ? 232 ASN B O 1 ATOM 4685 C CB . ASN B 1 248 ? -30.064 -21.929 2.737 1.00 14.84 ? 232 ASN B CB 1 ATOM 4686 C CG . ASN B 1 248 ? -29.619 -23.323 3.136 1.00 11.92 ? 232 ASN B CG 1 ATOM 4687 O OD1 . ASN B 1 248 ? -29.626 -24.247 2.322 1.00 13.30 ? 232 ASN B OD1 1 ATOM 4688 N ND2 . ASN B 1 248 ? -29.250 -23.488 4.401 1.00 10.09 ? 232 ASN B ND2 1 ATOM 4689 N N . ARG B 1 249 ? -30.526 -19.884 0.289 1.00 20.28 ? 233 ARG B N 1 ATOM 4690 C CA . ARG B 1 249 ? -31.137 -18.641 -0.166 1.00 18.92 ? 233 ARG B CA 1 ATOM 4691 C C . ARG B 1 249 ? -30.090 -17.595 -0.538 1.00 21.33 ? 233 ARG B C 1 ATOM 4692 O O . ARG B 1 249 ? -30.184 -16.441 -0.119 1.00 20.56 ? 233 ARG B O 1 ATOM 4693 C CB . ARG B 1 249 ? -32.063 -18.070 0.912 1.00 16.64 ? 233 ARG B CB 1 ATOM 4694 C CG . ARG B 1 249 ? -33.121 -19.038 1.416 1.00 14.20 ? 233 ARG B CG 1 ATOM 4695 C CD . ARG B 1 249 ? -33.879 -19.689 0.270 1.00 26.55 ? 233 ARG B CD 1 ATOM 4696 N NE . ARG B 1 249 ? -34.270 -18.726 -0.756 1.00 38.71 ? 233 ARG B NE 1 ATOM 4697 C CZ . ARG B 1 249 ? -35.292 -17.880 -0.651 1.00 34.29 ? 233 ARG B CZ 1 ATOM 4698 N NH1 . ARG B 1 249 ? -36.039 -17.855 0.446 1.00 34.62 ? 233 ARG B NH1 1 ATOM 4699 N NH2 . ARG B 1 249 ? -35.563 -17.047 -1.645 1.00 32.09 ? 233 ARG B NH2 1 ATOM 4700 N N . GLN B 1 250 ? -29.097 -17.995 -1.325 1.00 21.70 ? 234 GLN B N 1 ATOM 4701 C CA . GLN B 1 250 ? -28.081 -17.056 -1.790 1.00 18.93 ? 234 GLN B CA 1 ATOM 4702 C C . GLN B 1 250 ? -28.692 -16.081 -2.788 1.00 20.19 ? 234 GLN B C 1 ATOM 4703 O O . GLN B 1 250 ? -28.215 -14.958 -2.949 1.00 23.56 ? 234 GLN B O 1 ATOM 4704 C CB . GLN B 1 250 ? -26.914 -17.792 -2.447 1.00 18.30 ? 234 GLN B CB 1 ATOM 4705 C CG . GLN B 1 250 ? -26.308 -18.891 -1.598 1.00 15.44 ? 234 GLN B CG 1 ATOM 4706 C CD . GLN B 1 250 ? -26.680 -20.273 -2.095 1.00 23.96 ? 234 GLN B CD 1 ATOM 4707 O OE1 . GLN B 1 250 ? -27.841 -20.678 -2.029 1.00 35.05 ? 234 GLN B OE1 1 ATOM 4708 N NE2 . GLN B 1 250 ? -25.696 -21.002 -2.608 1.00 17.50 ? 234 GLN B NE2 1 ATOM 4709 N N . ASP B 1 251 ? -29.752 -16.521 -3.458 1.00 18.82 ? 235 ASP B N 1 ATOM 4710 C CA . ASP B 1 251 ? -30.450 -15.692 -4.437 1.00 18.53 ? 235 ASP B CA 1 ATOM 4711 C C . ASP B 1 251 ? -31.003 -14.403 -3.830 1.00 16.14 ? 235 ASP B C 1 ATOM 4712 O O . ASP B 1 251 ? -31.484 -13.529 -4.551 1.00 19.96 ? 235 ASP B O 1 ATOM 4713 C CB . ASP B 1 251 ? -31.586 -16.485 -5.091 1.00 22.20 ? 235 ASP B CB 1 ATOM 4714 C CG . ASP B 1 251 ? -32.503 -17.143 -4.075 1.00 25.97 ? 235 ASP B CG 1 ATOM 4715 O OD1 . ASP B 1 251 ? -33.360 -16.438 -3.500 1.00 26.28 ? 235 ASP B OD1 1 ATOM 4716 O OD2 . ASP B 1 251 ? -32.369 -18.366 -3.856 1.00 24.35 ? 235 ASP B OD2 1 ATOM 4717 N N . LEU B 1 252 ? -30.933 -14.288 -2.508 1.00 19.62 ? 236 LEU B N 1 ATOM 4718 C CA . LEU B 1 252 ? -31.380 -13.084 -1.823 1.00 17.36 ? 236 LEU B CA 1 ATOM 4719 C C . LEU B 1 252 ? -30.379 -11.943 -1.996 1.00 24.86 ? 236 LEU B C 1 ATOM 4720 O O . LEU B 1 252 ? -30.758 -10.771 -1.978 1.00 31.74 ? 236 LEU B O 1 ATOM 4721 C CB . LEU B 1 252 ? -31.592 -13.378 -0.338 1.00 13.86 ? 236 LEU B CB 1 ATOM 4722 C CG . LEU B 1 252 ? -32.645 -14.443 -0.022 1.00 14.79 ? 236 LEU B CG 1 ATOM 4723 C CD1 . LEU B 1 252 ? -32.694 -14.728 1.473 1.00 18.15 ? 236 LEU B CD1 1 ATOM 4724 C CD2 . LEU B 1 252 ? -34.008 -14.010 -0.528 1.00 20.25 ? 236 LEU B CD2 1 ATOM 4725 N N . LEU B 1 253 ? -29.105 -12.287 -2.162 1.00 19.76 ? 237 LEU B N 1 ATOM 4726 C CA . LEU B 1 253 ? -28.064 -11.284 -2.368 1.00 19.81 ? 237 LEU B CA 1 ATOM 4727 C C . LEU B 1 253 ? -27.485 -11.338 -3.780 1.00 25.73 ? 237 LEU B C 1 ATOM 4728 O O . LEU B 1 253 ? -26.733 -10.449 -4.179 1.00 23.56 ? 237 LEU B O 1 ATOM 4729 C CB . LEU B 1 253 ? -26.937 -11.464 -1.348 1.00 18.97 ? 237 LEU B CB 1 ATOM 4730 C CG . LEU B 1 253 ? -27.295 -11.252 0.125 1.00 21.51 ? 237 LEU B CG 1 ATOM 4731 C CD1 . LEU B 1 253 ? -26.047 -11.367 0.984 1.00 20.46 ? 237 LEU B CD1 1 ATOM 4732 C CD2 . LEU B 1 253 ? -27.967 -9.907 0.343 1.00 24.95 ? 237 LEU B CD2 1 ATOM 4733 N N . VAL B 1 254 ? -27.837 -12.376 -4.532 1.00 25.77 ? 238 VAL B N 1 ATOM 4734 C CA . VAL B 1 254 ? -27.296 -12.565 -5.873 1.00 20.44 ? 238 VAL B CA 1 ATOM 4735 C C . VAL B 1 254 ? -28.372 -12.356 -6.930 1.00 28.22 ? 238 VAL B C 1 ATOM 4736 O O . VAL B 1 254 ? -29.457 -12.932 -6.846 1.00 25.08 ? 238 VAL B O 1 ATOM 4737 C CB . VAL B 1 254 ? -26.714 -13.976 -6.039 1.00 12.45 ? 238 VAL B CB 1 ATOM 4738 C CG1 . VAL B 1 254 ? -26.098 -14.131 -7.412 1.00 21.71 ? 238 VAL B CG1 1 ATOM 4739 C CG2 . VAL B 1 254 ? -25.680 -14.249 -4.965 1.00 17.41 ? 238 VAL B CG2 1 ATOM 4740 N N . THR B 1 255 ? -28.061 -11.537 -7.930 1.00 32.39 ? 239 THR B N 1 ATOM 4741 C CA . THR B 1 255 ? -28.999 -11.254 -9.010 1.00 31.05 ? 239 THR B CA 1 ATOM 4742 C C . THR B 1 255 ? -28.422 -11.665 -10.360 1.00 32.39 ? 239 THR B C 1 ATOM 4743 O O . THR B 1 255 ? -27.340 -11.222 -10.747 1.00 29.84 ? 239 THR B O 1 ATOM 4744 C CB . THR B 1 255 ? -29.350 -9.754 -9.075 1.00 36.32 ? 239 THR B CB 1 ATOM 4745 O OG1 . THR B 1 255 ? -29.774 -9.298 -7.785 1.00 31.36 ? 239 THR B OG1 1 ATOM 4746 C CG2 . THR B 1 255 ? -30.455 -9.507 -10.093 1.00 28.65 ? 239 THR B CG2 1 ATOM 4747 N N . PHE B 1 256 ? -29.152 -12.517 -11.070 1.00 31.93 ? 240 PHE B N 1 ATOM 4748 C CA . PHE B 1 256 ? -28.789 -12.895 -12.430 1.00 27.43 ? 240 PHE B CA 1 ATOM 4749 C C . PHE B 1 256 ? -29.461 -11.949 -13.415 1.00 30.80 ? 240 PHE B C 1 ATOM 4750 O O . PHE B 1 256 ? -30.674 -12.010 -13.613 1.00 37.95 ? 240 PHE B O 1 ATOM 4751 C CB . PHE B 1 256 ? -29.232 -14.328 -12.726 1.00 24.64 ? 240 PHE B CB 1 ATOM 4752 C CG . PHE B 1 256 ? -28.433 -15.375 -12.004 1.00 29.80 ? 240 PHE B CG 1 ATOM 4753 C CD1 . PHE B 1 256 ? -28.553 -15.537 -10.634 1.00 28.44 ? 240 PHE B CD1 1 ATOM 4754 C CD2 . PHE B 1 256 ? -27.571 -16.208 -12.698 1.00 26.11 ? 240 PHE B CD2 1 ATOM 4755 C CE1 . PHE B 1 256 ? -27.820 -16.501 -9.969 1.00 18.97 ? 240 PHE B CE1 1 ATOM 4756 C CE2 . PHE B 1 256 ? -26.838 -17.174 -12.039 1.00 18.95 ? 240 PHE B CE2 1 ATOM 4757 C CZ . PHE B 1 256 ? -26.964 -17.321 -10.674 1.00 22.32 ? 240 PHE B CZ 1 ATOM 4758 N N . LYS B 1 257 ? -28.675 -11.072 -14.029 1.00 27.02 ? 241 LYS B N 1 ATOM 4759 C CA . LYS B 1 257 ? -29.217 -10.119 -14.991 1.00 31.17 ? 241 LYS B CA 1 ATOM 4760 C C . LYS B 1 257 ? -29.546 -10.819 -16.307 1.00 38.60 ? 241 LYS B C 1 ATOM 4761 O O . LYS B 1 257 ? -29.041 -11.907 -16.583 1.00 37.06 ? 241 LYS B O 1 ATOM 4762 C CB . LYS B 1 257 ? -28.239 -8.963 -15.222 1.00 35.71 ? 241 LYS B CB 1 ATOM 4763 C CG . LYS B 1 257 ? -28.672 -7.651 -14.578 1.00 47.44 ? 241 LYS B CG 1 ATOM 4764 C CD . LYS B 1 257 ? -29.947 -7.108 -15.209 1.00 49.73 ? 241 LYS B CD 1 ATOM 4765 C CE . LYS B 1 257 ? -29.702 -6.577 -16.616 1.00 46.96 ? 241 LYS B CE 1 ATOM 4766 N NZ . LYS B 1 257 ? -30.972 -6.293 -17.341 1.00 56.50 ? 241 LYS B NZ 1 ATOM 4767 N N . THR B 1 258 ? -30.401 -10.189 -17.108 1.00 44.94 ? 242 THR B N 1 ATOM 4768 C CA . THR B 1 258 ? -30.867 -10.774 -18.363 1.00 37.66 ? 242 THR B CA 1 ATOM 4769 C C . THR B 1 258 ? -29.735 -11.467 -19.113 1.00 31.30 ? 242 THR B C 1 ATOM 4770 O O . THR B 1 258 ? -28.595 -11.004 -19.104 1.00 39.10 ? 242 THR B O 1 ATOM 4771 C CB . THR B 1 258 ? -31.498 -9.710 -19.284 1.00 38.03 ? 242 THR B CB 1 ATOM 4772 O OG1 . THR B 1 258 ? -31.998 -10.336 -20.473 1.00 37.72 ? 242 THR B OG1 1 ATOM 4773 C CG2 . THR B 1 258 ? -30.476 -8.646 -19.665 1.00 39.03 ? 242 THR B CG2 1 ATOM 4774 N N . ALA B 1 259 ? -30.062 -12.579 -19.763 1.00 27.29 ? 243 ALA B N 1 ATOM 4775 C CA . ALA B 1 259 ? -29.059 -13.392 -20.437 1.00 30.29 ? 243 ALA B CA 1 ATOM 4776 C C . ALA B 1 259 ? -28.990 -13.104 -21.931 1.00 36.93 ? 243 ALA B C 1 ATOM 4777 O O . ALA B 1 259 ? -30.014 -12.920 -22.590 1.00 41.28 ? 243 ALA B O 1 ATOM 4778 C CB . ALA B 1 259 ? -29.352 -14.862 -20.210 1.00 30.28 ? 243 ALA B CB 1 ATOM 4779 N N . HIS B 1 260 ? -27.770 -13.070 -22.456 1.00 33.84 ? 244 HIS B N 1 ATOM 4780 C CA . HIS B 1 260 ? -27.556 -12.981 -23.891 1.00 29.79 ? 244 HIS B CA 1 ATOM 4781 C C . HIS B 1 260 ? -27.174 -14.362 -24.408 1.00 31.96 ? 244 HIS B C 1 ATOM 4782 O O . HIS B 1 260 ? -26.971 -15.289 -23.624 1.00 37.71 ? 244 HIS B O 1 ATOM 4783 C CB . HIS B 1 260 ? -26.473 -11.966 -24.209 1.00 36.12 ? 244 HIS B CB 1 ATOM 4784 N N . ALA B 1 261 ? -27.081 -14.495 -25.725 1.00 34.23 ? 245 ALA B N 1 ATOM 4785 C CA . ALA B 1 261 ? -26.813 -15.784 -26.351 1.00 31.04 ? 245 ALA B CA 1 ATOM 4786 C C . ALA B 1 261 ? -25.744 -16.600 -25.625 1.00 25.83 ? 245 ALA B C 1 ATOM 4787 O O . ALA B 1 261 ? -25.911 -17.803 -25.423 1.00 33.59 ? 245 ALA B O 1 ATOM 4788 C CB . ALA B 1 261 ? -26.414 -15.584 -27.800 1.00 41.66 ? 245 ALA B CB 1 ATOM 4789 N N . LYS B 1 262 ? -24.650 -15.952 -25.235 1.00 34.15 ? 246 LYS B N 1 ATOM 4790 C CA . LYS B 1 262 ? -23.494 -16.678 -24.718 1.00 23.58 ? 246 LYS B CA 1 ATOM 4791 C C . LYS B 1 262 ? -22.951 -16.147 -23.392 1.00 25.88 ? 246 LYS B C 1 ATOM 4792 O O . LYS B 1 262 ? -21.824 -16.469 -23.017 1.00 36.25 ? 246 LYS B O 1 ATOM 4793 C CB . LYS B 1 262 ? -22.387 -16.677 -25.757 1.00 26.61 ? 246 LYS B CB 1 ATOM 4794 N N . LYS B 1 263 ? -23.735 -15.347 -22.676 1.00 30.22 ? 247 LYS B N 1 ATOM 4795 C CA . LYS B 1 263 ? -23.256 -14.795 -21.410 1.00 26.11 ? 247 LYS B CA 1 ATOM 4796 C C . LYS B 1 263 ? -24.363 -14.250 -20.511 1.00 32.66 ? 247 LYS B C 1 ATOM 4797 O O . LYS B 1 263 ? -25.471 -13.964 -20.965 1.00 38.04 ? 247 LYS B O 1 ATOM 4798 C CB . LYS B 1 263 ? -22.223 -13.708 -21.678 1.00 35.45 ? 247 LYS B CB 1 ATOM 4799 N N . GLN B 1 264 ? -24.037 -14.120 -19.227 1.00 27.92 ? 248 GLN B N 1 ATOM 4800 C CA . GLN B 1 264 ? -24.914 -13.498 -18.241 1.00 25.85 ? 248 GLN B CA 1 ATOM 4801 C C . GLN B 1 264 ? -24.083 -12.665 -17.277 1.00 33.74 ? 248 GLN B C 1 ATOM 4802 O O . GLN B 1 264 ? -22.951 -13.025 -16.953 1.00 38.85 ? 248 GLN B O 1 ATOM 4803 C CB . GLN B 1 264 ? -25.677 -14.553 -17.441 1.00 30.80 ? 248 GLN B CB 1 ATOM 4804 C CG . GLN B 1 264 ? -26.818 -15.210 -18.188 1.00 32.68 ? 248 GLN B CG 1 ATOM 4805 C CD . GLN B 1 264 ? -27.840 -15.832 -17.254 1.00 25.79 ? 248 GLN B CD 1 ATOM 4806 O OE1 . GLN B 1 264 ? -28.033 -17.048 -17.245 1.00 20.47 ? 248 GLN B OE1 1 ATOM 4807 N NE2 . GLN B 1 264 ? -28.506 -14.996 -16.465 1.00 29.91 ? 248 GLN B NE2 1 ATOM 4808 N N . GLU B 1 265 ? -24.646 -11.554 -16.813 1.00 40.92 ? 249 GLU B N 1 ATOM 4809 C CA . GLU B 1 265 ? -23.995 -10.754 -15.784 1.00 40.61 ? 249 GLU B CA 1 ATOM 4810 C C . GLU B 1 265 ? -24.545 -11.135 -14.415 1.00 39.35 ? 249 GLU B C 1 ATOM 4811 O O . GLU B 1 265 ? -25.744 -11.014 -14.163 1.00 30.68 ? 249 GLU B O 1 ATOM 4812 C CB . GLU B 1 265 ? -24.212 -9.260 -16.025 1.00 36.30 ? 249 GLU B CB 1 ATOM 4813 C CG . GLU B 1 265 ? -22.987 -8.411 -15.711 1.00 42.77 ? 249 GLU B CG 1 ATOM 4814 C CD . GLU B 1 265 ? -23.327 -6.960 -15.429 1.00 55.91 ? 249 GLU B CD 1 ATOM 4815 O OE1 . GLU B 1 265 ? -24.529 -6.621 -15.396 1.00 59.51 ? 249 GLU B OE1 1 ATOM 4816 O OE2 . GLU B 1 265 ? -22.389 -6.156 -15.239 1.00 55.57 ? 249 GLU B OE2 1 ATOM 4817 N N . VAL B 1 266 ? -23.665 -11.605 -13.537 1.00 36.93 ? 250 VAL B N 1 ATOM 4818 C CA . VAL B 1 266 ? -24.049 -11.948 -12.174 1.00 31.98 ? 250 VAL B CA 1 ATOM 4819 C C . VAL B 1 266 ? -23.490 -10.913 -11.207 1.00 34.69 ? 250 VAL B C 1 ATOM 4820 O O . VAL B 1 266 ? -22.290 -10.641 -11.203 1.00 33.06 ? 250 VAL B O 1 ATOM 4821 C CB . VAL B 1 266 ? -23.533 -13.341 -11.779 1.00 25.09 ? 250 VAL B CB 1 ATOM 4822 C CG1 . VAL B 1 266 ? -23.792 -13.608 -10.306 1.00 26.34 ? 250 VAL B CG1 1 ATOM 4823 C CG2 . VAL B 1 266 ? -24.190 -14.413 -12.635 1.00 25.66 ? 250 VAL B CG2 1 ATOM 4824 N N . VAL B 1 267 ? -24.367 -10.341 -10.389 1.00 37.85 ? 251 VAL B N 1 ATOM 4825 C CA . VAL B 1 267 ? -23.972 -9.293 -9.456 1.00 37.08 ? 251 VAL B CA 1 ATOM 4826 C C . VAL B 1 267 ? -24.482 -9.577 -8.051 1.00 26.45 ? 251 VAL B C 1 ATOM 4827 O O . VAL B 1 267 ? -25.351 -10.424 -7.849 1.00 30.65 ? 251 VAL B O 1 ATOM 4828 C CB . VAL B 1 267 ? -24.504 -7.916 -9.901 1.00 36.67 ? 251 VAL B CB 1 ATOM 4829 C CG1 . VAL B 1 267 ? -23.692 -7.387 -11.072 1.00 43.13 ? 251 VAL B CG1 1 ATOM 4830 C CG2 . VAL B 1 267 ? -25.985 -8.001 -10.254 1.00 31.44 ? 251 VAL B CG2 1 ATOM 4831 N N . VAL B 1 268 ? -23.928 -8.859 -7.081 1.00 27.95 ? 252 VAL B N 1 ATOM 4832 C CA . VAL B 1 268 ? -24.348 -8.984 -5.693 1.00 22.16 ? 252 VAL B CA 1 ATOM 4833 C C . VAL B 1 268 ? -24.750 -7.629 -5.136 1.00 25.50 ? 252 VAL B C 1 ATOM 4834 O O . VAL B 1 268 ? -24.219 -6.596 -5.543 1.00 29.07 ? 252 VAL B O 1 ATOM 4835 C CB . VAL B 1 268 ? -23.228 -9.557 -4.805 1.00 24.60 ? 252 VAL B CB 1 ATOM 4836 C CG1 . VAL B 1 268 ? -23.087 -11.046 -5.033 1.00 31.92 ? 252 VAL B CG1 1 ATOM 4837 C CG2 . VAL B 1 268 ? -21.912 -8.841 -5.072 1.00 25.90 ? 252 VAL B CG2 1 ATOM 4838 N N . LEU B 1 269 ? -25.695 -7.638 -4.205 1.00 26.59 ? 253 LEU B N 1 ATOM 4839 C CA . LEU B 1 269 ? -26.102 -6.418 -3.528 1.00 26.09 ? 253 LEU B CA 1 ATOM 4840 C C . LEU B 1 269 ? -24.991 -5.953 -2.600 1.00 24.31 ? 253 LEU B C 1 ATOM 4841 O O . LEU B 1 269 ? -24.192 -6.758 -2.122 1.00 23.29 ? 253 LEU B O 1 ATOM 4842 C CB . LEU B 1 269 ? -27.380 -6.652 -2.721 1.00 23.76 ? 253 LEU B CB 1 ATOM 4843 C CG . LEU B 1 269 ? -28.681 -6.776 -3.513 1.00 25.46 ? 253 LEU B CG 1 ATOM 4844 C CD1 . LEU B 1 269 ? -29.819 -7.209 -2.599 1.00 17.42 ? 253 LEU B CD1 1 ATOM 4845 C CD2 . LEU B 1 269 ? -29.014 -5.459 -4.197 1.00 20.95 ? 253 LEU B CD2 1 ATOM 4846 N N . GLY B 1 270 ? -24.936 -4.650 -2.353 1.00 21.53 ? 254 GLY B N 1 ATOM 4847 C CA . GLY B 1 270 ? -23.983 -4.105 -1.407 1.00 28.31 ? 254 GLY B CA 1 ATOM 4848 C C . GLY B 1 270 ? -24.251 -4.665 -0.026 1.00 24.24 ? 254 GLY B C 1 ATOM 4849 O O . GLY B 1 270 ? -25.307 -5.248 0.217 1.00 26.39 ? 254 GLY B O 1 ATOM 4850 N N . SER B 1 271 ? -23.295 -4.495 0.879 1.00 21.58 ? 255 SER B N 1 ATOM 4851 C CA . SER B 1 271 ? -23.450 -4.973 2.246 1.00 19.14 ? 255 SER B CA 1 ATOM 4852 C C . SER B 1 271 ? -24.830 -4.621 2.787 1.00 23.48 ? 255 SER B C 1 ATOM 4853 O O . SER B 1 271 ? -25.413 -3.603 2.413 1.00 26.77 ? 255 SER B O 1 ATOM 4854 C CB . SER B 1 271 ? -22.369 -4.372 3.146 1.00 21.07 ? 255 SER B CB 1 ATOM 4855 O OG . SER B 1 271 ? -22.600 -4.697 4.506 1.00 21.75 ? 255 SER B OG 1 ATOM 4856 N N . GLN B 1 272 ? -25.344 -5.473 3.668 1.00 22.80 ? 256 GLN B N 1 ATOM 4857 C CA . GLN B 1 272 ? -26.646 -5.255 4.284 1.00 19.58 ? 256 GLN B CA 1 ATOM 4858 C C . GLN B 1 272 ? -26.450 -4.897 5.753 1.00 18.75 ? 256 GLN B C 1 ATOM 4859 O O . GLN B 1 272 ? -27.364 -5.037 6.564 1.00 14.21 ? 256 GLN B O 1 ATOM 4860 C CB . GLN B 1 272 ? -27.521 -6.506 4.158 1.00 24.18 ? 256 GLN B CB 1 ATOM 4861 C CG . GLN B 1 272 ? -27.673 -7.017 2.736 1.00 20.63 ? 256 GLN B CG 1 ATOM 4862 C CD . GLN B 1 272 ? -28.037 -5.916 1.766 1.00 25.47 ? 256 GLN B CD 1 ATOM 4863 O OE1 . GLN B 1 272 ? -28.866 -5.056 2.067 1.00 26.06 ? 256 GLN B OE1 1 ATOM 4864 N NE2 . GLN B 1 272 ? -27.407 -5.926 0.597 1.00 31.33 ? 256 GLN B NE2 1 ATOM 4865 N N . GLU B 1 273 ? -25.246 -4.443 6.087 1.00 18.11 ? 257 GLU B N 1 ATOM 4866 C CA . GLU B 1 273 ? -24.920 -4.062 7.457 1.00 15.91 ? 257 GLU B CA 1 ATOM 4867 C C . GLU B 1 273 ? -25.751 -2.868 7.906 1.00 15.26 ? 257 GLU B C 1 ATOM 4868 O O . GLU B 1 273 ? -26.210 -2.815 9.047 1.00 21.14 ? 257 GLU B O 1 ATOM 4869 C CB . GLU B 1 273 ? -23.432 -3.730 7.576 1.00 18.06 ? 257 GLU B CB 1 ATOM 4870 C CG . GLU B 1 273 ? -23.067 -2.949 8.828 1.00 19.19 ? 257 GLU B CG 1 ATOM 4871 C CD . GLU B 1 273 ? -21.574 -2.925 9.078 1.00 15.64 ? 257 GLU B CD 1 ATOM 4872 O OE1 . GLU B 1 273 ? -20.820 -3.450 8.231 1.00 22.66 ? 257 GLU B OE1 1 ATOM 4873 O OE2 . GLU B 1 273 ? -21.151 -2.376 10.117 1.00 21.36 ? 257 GLU B OE2 1 ATOM 4874 N N . GLY B 1 274 ? -25.935 -1.909 7.006 1.00 16.67 ? 258 GLY B N 1 ATOM 4875 C CA . GLY B 1 274 ? -26.728 -0.730 7.301 1.00 16.06 ? 258 GLY B CA 1 ATOM 4876 C C . GLY B 1 274 ? -28.182 -1.080 7.542 1.00 16.86 ? 258 GLY B C 1 ATOM 4877 O O . GLY B 1 274 ? -28.763 -0.695 8.556 1.00 19.15 ? 258 GLY B O 1 ATOM 4878 N N . ALA B 1 275 ? -28.772 -1.809 6.601 1.00 14.89 ? 259 ALA B N 1 ATOM 4879 C CA . ALA B 1 275 ? -30.161 -2.231 6.719 1.00 14.95 ? 259 ALA B CA 1 ATOM 4880 C C . ALA B 1 275 ? -30.377 -3.030 8.000 1.00 13.14 ? 259 ALA B C 1 ATOM 4881 O O . ALA B 1 275 ? -31.456 -2.993 8.591 1.00 10.56 ? 259 ALA B O 1 ATOM 4882 C CB . ALA B 1 275 ? -30.563 -3.055 5.510 1.00 12.22 ? 259 ALA B CB 1 ATOM 4883 N N . MET B 1 276 ? -29.346 -3.755 8.422 1.00 12.76 ? 260 MET B N 1 ATOM 4884 C CA . MET B 1 276 ? -29.422 -4.547 9.641 1.00 13.03 ? 260 MET B CA 1 ATOM 4885 C C . MET B 1 276 ? -29.388 -3.638 10.862 1.00 12.19 ? 260 MET B C 1 ATOM 4886 O O . MET B 1 276 ? -30.091 -3.876 11.843 1.00 17.98 ? 260 MET B O 1 ATOM 4887 C CB . MET B 1 276 ? -28.264 -5.543 9.699 1.00 14.59 ? 260 MET B CB 1 ATOM 4888 C CG . MET B 1 276 ? -28.355 -6.538 10.844 1.00 20.75 ? 260 MET B CG 1 ATOM 4889 S SD . MET B 1 276 ? -29.936 -7.401 10.897 1.00 19.72 ? 260 MET B SD 1 ATOM 4890 C CE . MET B 1 276 ? -30.024 -8.054 9.231 1.00 7.47 ? 260 MET B CE 1 ATOM 4891 N N . HIS B 1 277 ? -28.564 -2.598 10.797 1.00 15.90 ? 261 HIS B N 1 ATOM 4892 C CA . HIS B 1 277 ? -28.471 -1.633 11.884 1.00 17.63 ? 261 HIS B CA 1 ATOM 4893 C C . HIS B 1 277 ? -29.785 -0.883 12.077 1.00 15.15 ? 261 HIS B C 1 ATOM 4894 O O . HIS B 1 277 ? -30.137 -0.510 13.196 1.00 14.68 ? 261 HIS B O 1 ATOM 4895 C CB . HIS B 1 277 ? -27.344 -0.636 11.618 1.00 19.43 ? 261 HIS B CB 1 ATOM 4896 C CG . HIS B 1 277 ? -25.989 -1.132 12.021 1.00 18.33 ? 261 HIS B CG 1 ATOM 4897 N ND1 . HIS B 1 277 ? -24.824 -0.588 11.530 1.00 31.76 ? 261 HIS B ND1 1 ATOM 4898 C CD2 . HIS B 1 277 ? -25.618 -2.115 12.874 1.00 14.22 ? 261 HIS B CD2 1 ATOM 4899 C CE1 . HIS B 1 277 ? -23.791 -1.217 12.058 1.00 26.14 ? 261 HIS B CE1 1 ATOM 4900 N NE2 . HIS B 1 277 ? -24.243 -2.149 12.879 1.00 17.96 ? 261 HIS B NE2 1 ATOM 4901 N N . THR B 1 278 ? -30.504 -0.656 10.983 1.00 14.30 ? 262 THR B N 1 ATOM 4902 C CA . THR B 1 278 ? -31.777 0.054 11.042 1.00 14.43 ? 262 THR B CA 1 ATOM 4903 C C . THR B 1 278 ? -32.872 -0.848 11.598 1.00 16.12 ? 262 THR B C 1 ATOM 4904 O O . THR B 1 278 ? -33.797 -0.381 12.261 1.00 19.15 ? 262 THR B O 1 ATOM 4905 C CB . THR B 1 278 ? -32.201 0.561 9.651 1.00 12.73 ? 262 THR B CB 1 ATOM 4906 O OG1 . THR B 1 278 ? -31.197 1.443 9.134 1.00 21.22 ? 262 THR B OG1 1 ATOM 4907 C CG2 . THR B 1 278 ? -33.531 1.301 9.726 1.00 14.35 ? 262 THR B CG2 1 ATOM 4908 N N . ALA B 1 279 ? -32.762 -2.143 11.326 1.00 17.19 ? 263 ALA B N 1 ATOM 4909 C CA . ALA B 1 279 ? -33.742 -3.106 11.805 1.00 9.79 ? 263 ALA B CA 1 ATOM 4910 C C . ALA B 1 279 ? -33.514 -3.440 13.276 1.00 13.34 ? 263 ALA B C 1 ATOM 4911 O O . ALA B 1 279 ? -34.402 -3.969 13.945 1.00 10.34 ? 263 ALA B O 1 ATOM 4912 C CB . ALA B 1 279 ? -33.680 -4.365 10.969 1.00 9.46 ? 263 ALA B CB 1 ATOM 4913 N N . LEU B 1 280 ? -32.321 -3.133 13.775 1.00 10.32 ? 264 LEU B N 1 ATOM 4914 C CA . LEU B 1 280 ? -31.970 -3.432 15.159 1.00 11.78 ? 264 LEU B CA 1 ATOM 4915 C C . LEU B 1 280 ? -32.145 -2.223 16.075 1.00 15.29 ? 264 LEU B C 1 ATOM 4916 O O . LEU B 1 280 ? -31.977 -2.330 17.289 1.00 17.59 ? 264 LEU B O 1 ATOM 4917 C CB . LEU B 1 280 ? -30.530 -3.935 15.236 1.00 10.11 ? 264 LEU B CB 1 ATOM 4918 C CG . LEU B 1 280 ? -30.305 -5.347 14.693 1.00 8.36 ? 264 LEU B CG 1 ATOM 4919 C CD1 . LEU B 1 280 ? -28.839 -5.563 14.359 1.00 6.92 ? 264 LEU B CD1 1 ATOM 4920 C CD2 . LEU B 1 280 ? -30.786 -6.381 15.699 1.00 5.47 ? 264 LEU B CD2 1 ATOM 4921 N N . THR B 1 281 ? -32.478 -1.074 15.495 1.00 18.06 ? 265 THR B N 1 ATOM 4922 C CA . THR B 1 281 ? -32.715 0.129 16.285 1.00 16.17 ? 265 THR B CA 1 ATOM 4923 C C . THR B 1 281 ? -33.864 -0.115 17.251 1.00 19.11 ? 265 THR B C 1 ATOM 4924 O O . THR B 1 281 ? -35.020 -0.228 16.841 1.00 24.73 ? 265 THR B O 1 ATOM 4925 C CB . THR B 1 281 ? -33.051 1.344 15.396 1.00 17.66 ? 265 THR B CB 1 ATOM 4926 O OG1 . THR B 1 281 ? -31.950 1.628 14.524 1.00 16.28 ? 265 THR B OG1 1 ATOM 4927 C CG2 . THR B 1 281 ? -33.335 2.569 16.251 1.00 16.10 ? 265 THR B CG2 1 ATOM 4928 N N . GLY B 1 282 ? -33.537 -0.199 18.536 1.00 18.06 ? 266 GLY B N 1 ATOM 4929 C CA . GLY B 1 282 ? -34.521 -0.496 19.560 1.00 16.18 ? 266 GLY B CA 1 ATOM 4930 C C . GLY B 1 282 ? -34.166 -1.757 20.321 1.00 23.98 ? 266 GLY B C 1 ATOM 4931 O O . GLY B 1 282 ? -34.486 -1.890 21.502 1.00 29.50 ? 266 GLY B O 1 ATOM 4932 N N . ALA B 1 283 ? -33.504 -2.688 19.642 1.00 16.71 ? 267 ALA B N 1 ATOM 4933 C CA . ALA B 1 283 ? -33.069 -3.921 20.278 1.00 12.26 ? 267 ALA B CA 1 ATOM 4934 C C . ALA B 1 283 ? -31.933 -3.636 21.252 1.00 14.10 ? 267 ALA B C 1 ATOM 4935 O O . ALA B 1 283 ? -31.054 -2.820 20.973 1.00 21.39 ? 267 ALA B O 1 ATOM 4936 C CB . ALA B 1 283 ? -32.631 -4.918 19.232 1.00 13.76 ? 267 ALA B CB 1 ATOM 4937 N N . THR B 1 284 ? -31.956 -4.315 22.394 1.00 20.18 ? 268 THR B N 1 ATOM 4938 C CA . THR B 1 284 ? -30.967 -4.087 23.442 1.00 17.92 ? 268 THR B CA 1 ATOM 4939 C C . THR B 1 284 ? -29.564 -4.440 22.966 1.00 15.94 ? 268 THR B C 1 ATOM 4940 O O . THR B 1 284 ? -29.311 -5.560 22.526 1.00 19.11 ? 268 THR B O 1 ATOM 4941 C CB . THR B 1 284 ? -31.274 -4.919 24.704 1.00 17.77 ? 268 THR B CB 1 ATOM 4942 O OG1 . THR B 1 284 ? -32.571 -4.577 25.207 1.00 22.54 ? 268 THR B OG1 1 ATOM 4943 C CG2 . THR B 1 284 ? -30.226 -4.664 25.781 1.00 12.06 ? 268 THR B CG2 1 ATOM 4944 N N . GLU B 1 285 ? -28.659 -3.472 23.060 1.00 18.19 ? 269 GLU B N 1 ATOM 4945 C CA . GLU B 1 285 ? -27.262 -3.677 22.705 1.00 15.48 ? 269 GLU B CA 1 ATOM 4946 C C . GLU B 1 285 ? -26.494 -4.172 23.927 1.00 21.97 ? 269 GLU B C 1 ATOM 4947 O O . GLU B 1 285 ? -26.684 -3.663 25.031 1.00 22.58 ? 269 GLU B O 1 ATOM 4948 C CB . GLU B 1 285 ? -26.658 -2.364 22.207 1.00 22.51 ? 269 GLU B CB 1 ATOM 4949 C CG . GLU B 1 285 ? -25.489 -2.537 21.247 1.00 28.15 ? 269 GLU B CG 1 ATOM 4950 C CD . GLU B 1 285 ? -25.029 -1.226 20.639 1.00 32.86 ? 269 GLU B CD 1 ATOM 4951 O OE1 . GLU B 1 285 ? -25.889 -0.399 20.272 1.00 28.25 ? 269 GLU B OE1 1 ATOM 4952 O OE2 . GLU B 1 285 ? -23.802 -1.024 20.530 1.00 30.65 ? 269 GLU B OE2 1 ATOM 4953 N N . ILE B 1 286 ? -25.627 -5.162 23.730 1.00 24.84 ? 270 ILE B N 1 ATOM 4954 C CA . ILE B 1 286 ? -24.855 -5.726 24.834 1.00 16.24 ? 270 ILE B CA 1 ATOM 4955 C C . ILE B 1 286 ? -23.385 -5.881 24.453 1.00 19.09 ? 270 ILE B C 1 ATOM 4956 O O . ILE B 1 286 ? -23.018 -5.723 23.288 1.00 26.68 ? 270 ILE B O 1 ATOM 4957 C CB . ILE B 1 286 ? -25.423 -7.084 25.281 1.00 20.01 ? 270 ILE B CB 1 ATOM 4958 C CG1 . ILE B 1 286 ? -25.351 -8.098 24.141 1.00 22.19 ? 270 ILE B CG1 1 ATOM 4959 C CG2 . ILE B 1 286 ? -26.863 -6.925 25.745 1.00 15.91 ? 270 ILE B CG2 1 ATOM 4960 C CD1 . ILE B 1 286 ? -25.770 -9.487 24.549 1.00 15.08 ? 270 ILE B CD1 1 ATOM 4961 N N . GLN B 1 287 ? -22.548 -6.187 25.441 1.00 17.61 ? 271 GLN B N 1 ATOM 4962 C CA . GLN B 1 287 ? -21.107 -6.244 25.229 1.00 24.35 ? 271 GLN B CA 1 ATOM 4963 C C . GLN B 1 287 ? -20.573 -7.661 25.410 1.00 19.57 ? 271 GLN B C 1 ATOM 4964 O O . GLN B 1 287 ? -20.883 -8.333 26.394 1.00 19.05 ? 271 GLN B O 1 ATOM 4965 C CB . GLN B 1 287 ? -20.397 -5.288 26.192 1.00 29.61 ? 271 GLN B CB 1 ATOM 4966 C CG . GLN B 1 287 ? -20.130 -5.870 27.572 1.00 37.55 ? 271 GLN B CG 1 ATOM 4967 C CD . GLN B 1 287 ? -19.697 -4.818 28.574 1.00 42.31 ? 271 GLN B CD 1 ATOM 4968 O OE1 . GLN B 1 287 ? -19.966 -3.630 28.400 1.00 59.65 ? 271 GLN B OE1 1 ATOM 4969 N NE2 . GLN B 1 287 ? -19.018 -5.251 29.630 1.00 41.01 ? 271 GLN B NE2 1 ATOM 4970 N N . THR B 1 288 ? -19.769 -8.108 24.452 1.00 19.93 ? 272 THR B N 1 ATOM 4971 C CA . THR B 1 288 ? -19.171 -9.435 24.510 1.00 19.58 ? 272 THR B CA 1 ATOM 4972 C C . THR B 1 288 ? -17.777 -9.442 23.898 1.00 29.27 ? 272 THR B C 1 ATOM 4973 O O . THR B 1 288 ? -17.582 -9.000 22.765 1.00 40.90 ? 272 THR B O 1 ATOM 4974 C CB . THR B 1 288 ? -20.030 -10.470 23.764 1.00 32.72 ? 272 THR B CB 1 ATOM 4975 O OG1 . THR B 1 288 ? -19.189 -11.285 22.937 1.00 32.02 ? 272 THR B OG1 1 ATOM 4976 C CG2 . THR B 1 288 ? -21.067 -9.781 22.897 1.00 26.93 ? 272 THR B CG2 1 ATOM 4977 N N . SER B 1 289 ? -16.809 -9.951 24.654 1.00 27.82 ? 273 SER B N 1 ATOM 4978 C CA . SER B 1 289 ? -15.443 -10.076 24.163 1.00 29.37 ? 273 SER B CA 1 ATOM 4979 C C . SER B 1 289 ? -15.234 -11.450 23.540 1.00 28.79 ? 273 SER B C 1 ATOM 4980 O O . SER B 1 289 ? -14.593 -12.320 24.130 1.00 24.19 ? 273 SER B O 1 ATOM 4981 C CB . SER B 1 289 ? -14.441 -9.852 25.298 1.00 40.04 ? 273 SER B CB 1 ATOM 4982 O OG . SER B 1 289 ? -14.422 -10.941 26.207 1.00 35.18 ? 273 SER B OG 1 ATOM 4983 N N . GLY B 1 290 ? -15.783 -11.638 22.345 1.00 29.49 ? 274 GLY B N 1 ATOM 4984 C CA . GLY B 1 290 ? -15.677 -12.905 21.649 1.00 30.54 ? 274 GLY B CA 1 ATOM 4985 C C . GLY B 1 290 ? -16.629 -13.951 22.195 1.00 24.08 ? 274 GLY B C 1 ATOM 4986 O O . GLY B 1 290 ? -17.777 -14.044 21.759 1.00 27.00 ? 274 GLY B O 1 ATOM 4987 N N . THR B 1 291 ? -16.153 -14.736 23.157 1.00 23.20 ? 275 THR B N 1 ATOM 4988 C CA . THR B 1 291 ? -16.927 -15.851 23.695 1.00 23.94 ? 275 THR B CA 1 ATOM 4989 C C . THR B 1 291 ? -17.665 -15.492 24.982 1.00 20.01 ? 275 THR B C 1 ATOM 4990 O O . THR B 1 291 ? -18.637 -16.152 25.345 1.00 16.39 ? 275 THR B O 1 ATOM 4991 C CB . THR B 1 291 ? -16.022 -17.066 23.978 1.00 24.36 ? 275 THR B CB 1 ATOM 4992 O OG1 . THR B 1 291 ? -15.070 -16.735 24.997 1.00 28.43 ? 275 THR B OG1 1 ATOM 4993 C CG2 . THR B 1 291 ? -15.285 -17.490 22.717 1.00 17.32 ? 275 THR B CG2 1 ATOM 4994 N N . THR B 1 292 ? -17.202 -14.453 25.670 1.00 21.87 ? 276 THR B N 1 ATOM 4995 C CA . THR B 1 292 ? -17.780 -14.074 26.954 1.00 13.10 ? 276 THR B CA 1 ATOM 4996 C C . THR B 1 292 ? -18.662 -12.835 26.846 1.00 17.50 ? 276 THR B C 1 ATOM 4997 O O . THR B 1 292 ? -18.244 -11.802 26.322 1.00 13.86 ? 276 THR B O 1 ATOM 4998 C CB . THR B 1 292 ? -16.688 -13.801 28.001 1.00 15.38 ? 276 THR B CB 1 ATOM 4999 O OG1 . THR B 1 292 ? -15.830 -14.943 28.114 1.00 20.85 ? 276 THR B OG1 1 ATOM 5000 C CG2 . THR B 1 292 ? -17.314 -13.503 29.355 1.00 16.65 ? 276 THR B CG2 1 ATOM 5001 N N . THR B 1 293 ? -19.886 -12.953 27.347 1.00 18.61 ? 277 THR B N 1 ATOM 5002 C CA . THR B 1 293 ? -20.805 -11.828 27.436 1.00 12.92 ? 277 THR B CA 1 ATOM 5003 C C . THR B 1 293 ? -21.101 -11.555 28.905 1.00 15.00 ? 277 THR B C 1 ATOM 5004 O O . THR B 1 293 ? -21.281 -12.487 29.688 1.00 13.00 ? 277 THR B O 1 ATOM 5005 C CB . THR B 1 293 ? -22.132 -12.131 26.723 1.00 11.07 ? 277 THR B CB 1 ATOM 5006 O OG1 . THR B 1 293 ? -21.874 -12.617 25.401 1.00 13.96 ? 277 THR B OG1 1 ATOM 5007 C CG2 . THR B 1 293 ? -23.001 -10.889 26.647 1.00 11.15 ? 277 THR B CG2 1 ATOM 5008 N N . ILE B 1 294 ? -21.148 -10.280 29.279 1.00 11.20 ? 278 ILE B N 1 ATOM 5009 C CA . ILE B 1 294 ? -21.405 -9.906 30.664 1.00 11.81 ? 278 ILE B CA 1 ATOM 5010 C C . ILE B 1 294 ? -22.789 -9.287 30.822 1.00 12.91 ? 278 ILE B C 1 ATOM 5011 O O . ILE B 1 294 ? -23.191 -8.423 30.041 1.00 7.85 ? 278 ILE B O 1 ATOM 5012 C CB . ILE B 1 294 ? -20.341 -8.925 31.184 1.00 13.51 ? 278 ILE B CB 1 ATOM 5013 C CG1 . ILE B 1 294 ? -18.955 -9.572 31.128 1.00 12.99 ? 278 ILE B CG1 1 ATOM 5014 C CG2 . ILE B 1 294 ? -20.665 -8.495 32.604 1.00 15.24 ? 278 ILE B CG2 1 ATOM 5015 C CD1 . ILE B 1 294 ? -18.862 -10.881 31.877 1.00 12.79 ? 278 ILE B CD1 1 ATOM 5016 N N . PHE B 1 295 ? -23.506 -9.733 31.848 1.00 11.04 ? 279 PHE B N 1 ATOM 5017 C CA . PHE B 1 295 ? -24.864 -9.274 32.102 1.00 11.40 ? 279 PHE B CA 1 ATOM 5018 C C . PHE B 1 295 ? -24.995 -8.662 33.489 1.00 10.13 ? 279 PHE B C 1 ATOM 5019 O O . PHE B 1 295 ? -24.113 -8.804 34.335 1.00 15.07 ? 279 PHE B O 1 ATOM 5020 C CB . PHE B 1 295 ? -25.852 -10.436 31.972 1.00 11.11 ? 279 PHE B CB 1 ATOM 5021 C CG . PHE B 1 295 ? -26.110 -10.859 30.556 1.00 10.84 ? 279 PHE B CG 1 ATOM 5022 C CD1 . PHE B 1 295 ? -25.319 -11.818 29.949 1.00 14.18 ? 279 PHE B CD1 1 ATOM 5023 C CD2 . PHE B 1 295 ? -27.148 -10.298 29.832 1.00 13.47 ? 279 PHE B CD2 1 ATOM 5024 C CE1 . PHE B 1 295 ? -25.556 -12.209 28.645 1.00 12.18 ? 279 PHE B CE1 1 ATOM 5025 C CE2 . PHE B 1 295 ? -27.391 -10.685 28.528 1.00 12.31 ? 279 PHE B CE2 1 ATOM 5026 C CZ . PHE B 1 295 ? -26.594 -11.642 27.934 1.00 9.43 ? 279 PHE B CZ 1 ATOM 5027 N N . ALA B 1 296 ? -26.110 -7.974 33.706 1.00 15.97 ? 280 ALA B N 1 ATOM 5028 C CA . ALA B 1 296 ? -26.459 -7.454 35.018 1.00 16.65 ? 280 ALA B CA 1 ATOM 5029 C C . ALA B 1 296 ? -27.381 -8.460 35.702 1.00 17.65 ? 280 ALA B C 1 ATOM 5030 O O . ALA B 1 296 ? -28.585 -8.484 35.450 1.00 21.75 ? 280 ALA B O 1 ATOM 5031 C CB . ALA B 1 296 ? -27.138 -6.103 34.876 1.00 22.74 ? 280 ALA B CB 1 ATOM 5032 N N . GLY B 1 297 ? -26.803 -9.291 36.565 1.00 20.08 ? 281 GLY B N 1 ATOM 5033 C CA . GLY B 1 297 ? -27.499 -10.445 37.106 1.00 13.59 ? 281 GLY B CA 1 ATOM 5034 C C . GLY B 1 297 ? -28.490 -10.161 38.215 1.00 22.05 ? 281 GLY B C 1 ATOM 5035 O O . GLY B 1 297 ? -28.464 -9.106 38.849 1.00 21.07 ? 281 GLY B O 1 ATOM 5036 N N . HIS B 1 298 ? -29.372 -11.128 38.442 1.00 21.55 ? 282 HIS B N 1 ATOM 5037 C CA . HIS B 1 298 ? -30.343 -11.069 39.525 1.00 12.66 ? 282 HIS B CA 1 ATOM 5038 C C . HIS B 1 298 ? -30.540 -12.468 40.099 1.00 9.47 ? 282 HIS B C 1 ATOM 5039 O O . HIS B 1 298 ? -31.056 -13.351 39.416 1.00 13.33 ? 282 HIS B O 1 ATOM 5040 C CB . HIS B 1 298 ? -31.678 -10.535 39.010 1.00 16.51 ? 282 HIS B CB 1 ATOM 5041 C CG . HIS B 1 298 ? -31.585 -9.183 38.375 1.00 20.21 ? 282 HIS B CG 1 ATOM 5042 N ND1 . HIS B 1 298 ? -31.732 -8.014 39.089 1.00 25.04 ? 282 HIS B ND1 1 ATOM 5043 C CD2 . HIS B 1 298 ? -31.368 -8.813 37.090 1.00 22.12 ? 282 HIS B CD2 1 ATOM 5044 C CE1 . HIS B 1 298 ? -31.604 -6.982 38.275 1.00 24.27 ? 282 HIS B CE1 1 ATOM 5045 N NE2 . HIS B 1 298 ? -31.383 -7.440 37.055 1.00 20.25 ? 282 HIS B NE2 1 ATOM 5046 N N . LEU B 1 299 ? -30.124 -12.667 41.346 1.00 8.76 ? 283 LEU B N 1 ATOM 5047 C CA . LEU B 1 299 ? -30.237 -13.970 41.991 1.00 7.42 ? 283 LEU B CA 1 ATOM 5048 C C . LEU B 1 299 ? -31.182 -13.948 43.185 1.00 9.02 ? 283 LEU B C 1 ATOM 5049 O O . LEU B 1 299 ? -31.207 -12.992 43.959 1.00 7.42 ? 283 LEU B O 1 ATOM 5050 C CB . LEU B 1 299 ? -28.864 -14.452 42.466 1.00 10.13 ? 283 LEU B CB 1 ATOM 5051 C CG . LEU B 1 299 ? -27.949 -15.162 41.467 1.00 7.26 ? 283 LEU B CG 1 ATOM 5052 C CD1 . LEU B 1 299 ? -26.650 -15.563 42.155 1.00 11.28 ? 283 LEU B CD1 1 ATOM 5053 C CD2 . LEU B 1 299 ? -28.629 -16.380 40.861 1.00 7.35 ? 283 LEU B CD2 1 ATOM 5054 N N . LYS B 1 300 ? -31.956 -15.018 43.323 1.00 10.18 ? 284 LYS B N 1 ATOM 5055 C CA . LYS B 1 300 ? -32.717 -15.280 44.537 1.00 7.18 ? 284 LYS B CA 1 ATOM 5056 C C . LYS B 1 300 ? -32.070 -16.476 45.221 1.00 9.95 ? 284 LYS B C 1 ATOM 5057 O O . LYS B 1 300 ? -31.867 -17.515 44.594 1.00 11.01 ? 284 LYS B O 1 ATOM 5058 C CB . LYS B 1 300 ? -34.182 -15.576 44.211 1.00 8.73 ? 284 LYS B CB 1 ATOM 5059 C CG . LYS B 1 300 ? -34.879 -16.462 45.236 1.00 14.52 ? 284 LYS B CG 1 ATOM 5060 C CD . LYS B 1 300 ? -36.102 -15.794 45.836 1.00 21.54 ? 284 LYS B CD 1 ATOM 5061 C CE . LYS B 1 300 ? -36.288 -16.203 47.286 1.00 18.60 ? 284 LYS B CE 1 ATOM 5062 N NZ . LYS B 1 300 ? -35.229 -15.638 48.169 1.00 15.00 ? 284 LYS B NZ 1 ATOM 5063 N N . CYS B 1 301 ? -31.741 -16.327 46.501 1.00 11.95 ? 285 CYS B N 1 ATOM 5064 C CA . CYS B 1 301 ? -30.963 -17.340 47.204 1.00 9.22 ? 285 CYS B CA 1 ATOM 5065 C C . CYS B 1 301 ? -31.593 -17.809 48.509 1.00 4.96 ? 285 CYS B C 1 ATOM 5066 O O . CYS B 1 301 ? -32.326 -17.070 49.166 1.00 8.72 ? 285 CYS B O 1 ATOM 5067 C CB . CYS B 1 301 ? -29.565 -16.800 47.497 1.00 9.58 ? 285 CYS B CB 1 ATOM 5068 S SG . CYS B 1 301 ? -28.533 -16.555 46.035 1.00 14.24 ? 285 CYS B SG 1 ATOM 5069 N N . ARG B 1 302 ? -31.285 -19.051 48.871 1.00 5.61 ? 286 ARG B N 1 ATOM 5070 C CA . ARG B 1 302 ? -31.673 -19.614 50.156 1.00 4.93 ? 286 ARG B CA 1 ATOM 5071 C C . ARG B 1 302 ? -30.423 -20.018 50.933 1.00 7.75 ? 286 ARG B C 1 ATOM 5072 O O . ARG B 1 302 ? -29.771 -21.009 50.604 1.00 7.49 ? 286 ARG B O 1 ATOM 5073 C CB . ARG B 1 302 ? -32.584 -20.827 49.960 1.00 4.00 ? 286 ARG B CB 1 ATOM 5074 C CG . ARG B 1 302 ? -32.669 -21.754 51.167 1.00 4.46 ? 286 ARG B CG 1 ATOM 5075 C CD . ARG B 1 302 ? -33.111 -21.016 52.421 1.00 4.32 ? 286 ARG B CD 1 ATOM 5076 N NE . ARG B 1 302 ? -34.359 -20.286 52.218 1.00 3.61 ? 286 ARG B NE 1 ATOM 5077 C CZ . ARG B 1 302 ? -35.572 -20.824 52.299 1.00 5.14 ? 286 ARG B CZ 1 ATOM 5078 N NH1 . ARG B 1 302 ? -35.725 -22.113 52.574 1.00 3.16 ? 286 ARG B NH1 1 ATOM 5079 N NH2 . ARG B 1 302 ? -36.642 -20.071 52.097 1.00 2.53 ? 286 ARG B NH2 1 ATOM 5080 N N . LEU B 1 303 ? -30.089 -19.241 51.957 1.00 9.04 ? 287 LEU B N 1 ATOM 5081 C CA . LEU B 1 303 ? -28.942 -19.535 52.807 1.00 5.37 ? 287 LEU B CA 1 ATOM 5082 C C . LEU B 1 303 ? -29.318 -20.572 53.858 1.00 4.47 ? 287 LEU B C 1 ATOM 5083 O O . LEU B 1 303 ? -30.263 -20.374 54.621 1.00 4.86 ? 287 LEU B O 1 ATOM 5084 C CB . LEU B 1 303 ? -28.458 -18.260 53.499 1.00 3.92 ? 287 LEU B CB 1 ATOM 5085 C CG . LEU B 1 303 ? -27.431 -17.382 52.784 1.00 4.81 ? 287 LEU B CG 1 ATOM 5086 C CD1 . LEU B 1 303 ? -27.755 -17.224 51.307 1.00 6.57 ? 287 LEU B CD1 1 ATOM 5087 C CD2 . LEU B 1 303 ? -27.370 -16.023 53.467 1.00 1.32 ? 287 LEU B CD2 1 ATOM 5088 N N . LYS B 1 304 ? -28.581 -21.678 53.895 1.00 6.45 ? 288 LYS B N 1 ATOM 5089 C CA . LYS B 1 304 ? -28.803 -22.705 54.905 1.00 4.26 ? 288 LYS B CA 1 ATOM 5090 C C . LYS B 1 304 ? -27.630 -22.758 55.875 1.00 5.01 ? 288 LYS B C 1 ATOM 5091 O O . LYS B 1 304 ? -26.471 -22.810 55.465 1.00 7.51 ? 288 LYS B O 1 ATOM 5092 C CB . LYS B 1 304 ? -28.998 -24.075 54.256 1.00 4.03 ? 288 LYS B CB 1 ATOM 5093 C CG . LYS B 1 304 ? -30.146 -24.143 53.263 1.00 4.06 ? 288 LYS B CG 1 ATOM 5094 C CD . LYS B 1 304 ? -30.367 -25.568 52.787 1.00 1.94 ? 288 LYS B CD 1 ATOM 5095 C CE . LYS B 1 304 ? -31.590 -25.674 51.896 1.00 6.72 ? 288 LYS B CE 1 ATOM 5096 N NZ . LYS B 1 304 ? -31.794 -27.062 51.397 1.00 13.74 ? 288 LYS B NZ 1 ATOM 5097 N N . MET B 1 305 ? -27.940 -22.741 57.165 1.00 8.23 ? 289 MET B N 1 ATOM 5098 C CA . MET B 1 305 ? -26.918 -22.804 58.200 1.00 9.85 ? 289 MET B CA 1 ATOM 5099 C C . MET B 1 305 ? -27.504 -23.437 59.454 1.00 6.58 ? 289 MET B C 1 ATOM 5100 O O . MET B 1 305 ? -28.697 -23.731 59.505 1.00 10.07 ? 289 MET B O 1 ATOM 5101 C CB . MET B 1 305 ? -26.391 -21.402 58.512 1.00 5.98 ? 289 MET B CB 1 ATOM 5102 C CG . MET B 1 305 ? -27.479 -20.406 58.879 1.00 11.32 ? 289 MET B CG 1 ATOM 5103 S SD . MET B 1 305 ? -26.847 -18.754 59.235 1.00 22.40 ? 289 MET B SD 1 ATOM 5104 C CE . MET B 1 305 ? -25.964 -18.390 57.721 1.00 15.28 ? 289 MET B CE 1 ATOM 5105 N N . ASP B 1 306 ? -26.666 -23.649 60.463 1.00 6.43 ? 290 ASP B N 1 ATOM 5106 C CA . ASP B 1 306 ? -27.115 -24.264 61.706 1.00 7.27 ? 290 ASP B CA 1 ATOM 5107 C C . ASP B 1 306 ? -27.993 -23.308 62.503 1.00 9.73 ? 290 ASP B C 1 ATOM 5108 O O . ASP B 1 306 ? -28.053 -22.113 62.212 1.00 12.65 ? 290 ASP B O 1 ATOM 5109 C CB . ASP B 1 306 ? -25.919 -24.694 62.557 1.00 11.95 ? 290 ASP B CB 1 ATOM 5110 C CG . ASP B 1 306 ? -25.304 -25.998 62.087 1.00 11.88 ? 290 ASP B CG 1 ATOM 5111 O OD1 . ASP B 1 306 ? -26.024 -26.816 61.477 1.00 17.47 ? 290 ASP B OD1 1 ATOM 5112 O OD2 . ASP B 1 306 ? -24.099 -26.207 62.334 1.00 33.70 ? 290 ASP B OD2 1 ATOM 5113 N N . LYS B 1 307 ? -28.670 -23.846 63.513 1.00 10.72 ? 291 LYS B N 1 ATOM 5114 C CA . LYS B 1 307 ? -29.533 -23.044 64.373 1.00 6.11 ? 291 LYS B CA 1 ATOM 5115 C C . LYS B 1 307 ? -28.772 -21.861 64.958 1.00 7.41 ? 291 LYS B C 1 ATOM 5116 O O . LYS B 1 307 ? -28.016 -22.005 65.920 1.00 10.32 ? 291 LYS B O 1 ATOM 5117 C CB . LYS B 1 307 ? -30.117 -23.901 65.499 1.00 10.73 ? 291 LYS B CB 1 ATOM 5118 C CG . LYS B 1 307 ? -31.629 -24.076 65.430 1.00 5.27 ? 291 LYS B CG 1 ATOM 5119 C CD . LYS B 1 307 ? -32.126 -25.029 66.507 1.00 5.47 ? 291 LYS B CD 1 ATOM 5120 C CE . LYS B 1 307 ? -31.886 -24.483 67.909 1.00 5.44 ? 291 LYS B CE 1 ATOM 5121 N NZ . LYS B 1 307 ? -32.671 -23.248 68.188 1.00 11.30 ? 291 LYS B NZ 1 ATOM 5122 N N . LEU B 1 308 ? -28.982 -20.694 64.358 1.00 12.02 ? 292 LEU B N 1 ATOM 5123 C CA . LEU B 1 308 ? -28.334 -19.463 64.788 1.00 9.75 ? 292 LEU B CA 1 ATOM 5124 C C . LEU B 1 308 ? -29.346 -18.335 64.940 1.00 11.52 ? 292 LEU B C 1 ATOM 5125 O O . LEU B 1 308 ? -30.110 -18.043 64.020 1.00 17.80 ? 292 LEU B O 1 ATOM 5126 C CB . LEU B 1 308 ? -27.269 -19.049 63.774 1.00 13.69 ? 292 LEU B CB 1 ATOM 5127 C CG . LEU B 1 308 ? -25.909 -19.738 63.894 1.00 26.03 ? 292 LEU B CG 1 ATOM 5128 C CD1 . LEU B 1 308 ? -25.334 -20.046 62.520 1.00 15.42 ? 292 LEU B CD1 1 ATOM 5129 C CD2 . LEU B 1 308 ? -24.949 -18.868 64.688 1.00 26.70 ? 292 LEU B CD2 1 ATOM 5130 N N . THR B 1 309 ? -29.342 -17.698 66.106 1.00 10.67 ? 293 THR B N 1 ATOM 5131 C CA . THR B 1 309 ? -30.210 -16.557 66.351 1.00 8.41 ? 293 THR B CA 1 ATOM 5132 C C . THR B 1 309 ? -29.666 -15.333 65.619 1.00 14.79 ? 293 THR B C 1 ATOM 5133 O O . THR B 1 309 ? -28.697 -14.718 66.063 1.00 26.25 ? 293 THR B O 1 ATOM 5134 C CB . THR B 1 309 ? -30.306 -16.233 67.853 1.00 10.66 ? 293 THR B CB 1 ATOM 5135 O OG1 . THR B 1 309 ? -30.500 -17.439 68.601 1.00 18.96 ? 293 THR B OG1 1 ATOM 5136 C CG2 . THR B 1 309 ? -31.461 -15.285 68.120 1.00 4.95 ? 293 THR B CG2 1 ATOM 5137 N N . LEU B 1 310 ? -30.287 -14.985 64.496 1.00 10.82 ? 294 LEU B N 1 ATOM 5138 C CA . LEU B 1 310 ? -29.846 -13.843 63.701 1.00 6.73 ? 294 LEU B CA 1 ATOM 5139 C C . LEU B 1 310 ? -30.423 -12.545 64.250 1.00 7.36 ? 294 LEU B C 1 ATOM 5140 O O . LEU B 1 310 ? -31.471 -12.544 64.897 1.00 12.01 ? 294 LEU B O 1 ATOM 5141 C CB . LEU B 1 310 ? -30.263 -14.006 62.239 1.00 5.91 ? 294 LEU B CB 1 ATOM 5142 C CG . LEU B 1 310 ? -29.627 -15.156 61.457 1.00 6.96 ? 294 LEU B CG 1 ATOM 5143 C CD1 . LEU B 1 310 ? -30.045 -15.082 59.998 1.00 9.81 ? 294 LEU B CD1 1 ATOM 5144 C CD2 . LEU B 1 310 ? -28.112 -15.139 61.579 1.00 11.96 ? 294 LEU B CD2 1 ATOM 5145 N N . LYS B 1 311 ? -29.734 -11.441 63.982 1.00 12.48 ? 295 LYS B N 1 ATOM 5146 C CA . LYS B 1 311 ? -30.193 -10.126 64.402 1.00 12.54 ? 295 LYS B CA 1 ATOM 5147 C C . LYS B 1 311 ? -30.715 -9.361 63.190 1.00 14.42 ? 295 LYS B C 1 ATOM 5148 O O . LYS B 1 311 ? -29.940 -8.781 62.429 1.00 18.81 ? 295 LYS B O 1 ATOM 5149 C CB . LYS B 1 311 ? -29.050 -9.362 65.072 1.00 11.59 ? 295 LYS B CB 1 ATOM 5150 C CG . LYS B 1 311 ? -29.431 -7.988 65.596 1.00 20.28 ? 295 LYS B CG 1 ATOM 5151 C CD . LYS B 1 311 ? -28.345 -7.427 66.499 1.00 38.22 ? 295 LYS B CD 1 ATOM 5152 C CE . LYS B 1 311 ? -28.342 -5.910 66.494 1.00 44.49 ? 295 LYS B CE 1 ATOM 5153 N NZ . LYS B 1 311 ? -27.292 -5.356 67.392 1.00 43.80 ? 295 LYS B NZ 1 ATOM 5154 N N . GLY B 1 312 ? -32.033 -9.371 63.011 1.00 15.65 ? 296 GLY B N 1 ATOM 5155 C CA . GLY B 1 312 ? -32.651 -8.778 61.838 1.00 11.65 ? 296 GLY B CA 1 ATOM 5156 C C . GLY B 1 312 ? -32.599 -7.263 61.816 1.00 10.17 ? 296 GLY B C 1 ATOM 5157 O O . GLY B 1 312 ? -32.675 -6.608 62.856 1.00 14.94 ? 296 GLY B O 1 ATOM 5158 N N . MET B 1 313 ? -32.472 -6.709 60.614 1.00 12.39 ? 297 MET B N 1 ATOM 5159 C CA . MET B 1 313 ? -32.417 -5.266 60.421 1.00 13.50 ? 297 MET B CA 1 ATOM 5160 C C . MET B 1 313 ? -33.779 -4.726 60.008 1.00 12.09 ? 297 MET B C 1 ATOM 5161 O O . MET B 1 313 ? -34.449 -5.294 59.146 1.00 11.66 ? 297 MET B O 1 ATOM 5162 C CB . MET B 1 313 ? -31.389 -4.921 59.341 1.00 14.92 ? 297 MET B CB 1 ATOM 5163 C CG . MET B 1 313 ? -31.316 -3.439 58.991 1.00 13.99 ? 297 MET B CG 1 ATOM 5164 S SD . MET B 1 313 ? -30.345 -2.478 60.165 1.00 17.99 ? 297 MET B SD 1 ATOM 5165 C CE . MET B 1 313 ? -28.690 -3.031 59.756 1.00 12.81 ? 297 MET B CE 1 ATOM 5166 N N . SER B 1 314 ? -34.181 -3.624 60.631 1.00 17.00 ? 298 SER B N 1 ATOM 5167 C CA . SER B 1 314 ? -35.414 -2.939 60.267 1.00 16.95 ? 298 SER B CA 1 ATOM 5168 C C . SER B 1 314 ? -35.105 -1.536 59.762 1.00 14.35 ? 298 SER B C 1 ATOM 5169 O O . SER B 1 314 ? -34.335 -0.800 60.379 1.00 13.75 ? 298 SER B O 1 ATOM 5170 C CB . SER B 1 314 ? -36.359 -2.868 61.466 1.00 18.58 ? 298 SER B CB 1 ATOM 5171 O OG . SER B 1 314 ? -37.481 -3.715 61.283 1.00 31.66 ? 298 SER B OG 1 ATOM 5172 N N . TYR B 1 315 ? -35.707 -1.176 58.634 1.00 11.20 ? 299 TYR B N 1 ATOM 5173 C CA . TYR B 1 315 ? -35.508 0.140 58.042 1.00 12.64 ? 299 TYR B CA 1 ATOM 5174 C C . TYR B 1 315 ? -36.788 0.963 58.092 1.00 14.54 ? 299 TYR B C 1 ATOM 5175 O O . TYR B 1 315 ? -37.877 0.458 57.818 1.00 10.87 ? 299 TYR B O 1 ATOM 5176 C CB . TYR B 1 315 ? -35.039 0.009 56.593 1.00 12.71 ? 299 TYR B CB 1 ATOM 5177 C CG . TYR B 1 315 ? -33.627 -0.505 56.448 1.00 11.60 ? 299 TYR B CG 1 ATOM 5178 C CD1 . TYR B 1 315 ? -32.540 0.334 56.649 1.00 19.46 ? 299 TYR B CD1 1 ATOM 5179 C CD2 . TYR B 1 315 ? -33.380 -1.825 56.100 1.00 11.54 ? 299 TYR B CD2 1 ATOM 5180 C CE1 . TYR B 1 315 ? -31.246 -0.129 56.514 1.00 17.18 ? 299 TYR B CE1 1 ATOM 5181 C CE2 . TYR B 1 315 ? -32.089 -2.297 55.960 1.00 13.71 ? 299 TYR B CE2 1 ATOM 5182 C CZ . TYR B 1 315 ? -31.026 -1.444 56.170 1.00 14.31 ? 299 TYR B CZ 1 ATOM 5183 O OH . TYR B 1 315 ? -29.737 -1.904 56.034 1.00 14.99 ? 299 TYR B OH 1 ATOM 5184 N N . VAL B 1 316 ? -36.642 2.236 58.440 1.00 17.56 ? 300 VAL B N 1 ATOM 5185 C CA . VAL B 1 316 ? -37.766 3.162 58.472 1.00 17.46 ? 300 VAL B CA 1 ATOM 5186 C C . VAL B 1 316 ? -37.966 3.780 57.095 1.00 18.09 ? 300 VAL B C 1 ATOM 5187 O O . VAL B 1 316 ? -37.004 4.007 56.364 1.00 19.15 ? 300 VAL B O 1 ATOM 5188 C CB . VAL B 1 316 ? -37.551 4.295 59.505 1.00 27.07 ? 300 VAL B CB 1 ATOM 5189 C CG1 . VAL B 1 316 ? -37.427 3.721 60.909 1.00 24.15 ? 300 VAL B CG1 1 ATOM 5190 C CG2 . VAL B 1 316 ? -36.325 5.143 59.149 1.00 20.47 ? 300 VAL B CG2 1 ATOM 5191 N N . MET B 1 317 ? -39.220 4.042 56.742 1.00 21.99 ? 301 MET B N 1 ATOM 5192 C CA . MET B 1 317 ? -39.531 4.686 55.473 1.00 18.27 ? 301 MET B CA 1 ATOM 5193 C C . MET B 1 317 ? -38.838 6.039 55.398 1.00 19.08 ? 301 MET B C 1 ATOM 5194 O O . MET B 1 317 ? -38.848 6.803 56.363 1.00 22.80 ? 301 MET B O 1 ATOM 5195 C CB . MET B 1 317 ? -41.041 4.887 55.332 1.00 26.92 ? 301 MET B CB 1 ATOM 5196 C CG . MET B 1 317 ? -41.850 3.602 55.258 1.00 28.51 ? 301 MET B CG 1 ATOM 5197 S SD . MET B 1 317 ? -41.539 2.661 53.753 1.00 30.23 ? 301 MET B SD 1 ATOM 5198 C CE . MET B 1 317 ? -42.906 1.505 53.800 1.00 37.60 ? 301 MET B CE 1 ATOM 5199 N N . CYS B 1 318 ? -38.231 6.331 54.253 1.00 23.35 ? 302 CYS B N 1 ATOM 5200 C CA . CYS B 1 318 ? -37.622 7.635 54.033 1.00 18.64 ? 302 CYS B CA 1 ATOM 5201 C C . CYS B 1 318 ? -38.687 8.721 54.136 1.00 18.97 ? 302 CYS B C 1 ATOM 5202 O O . CYS B 1 318 ? -39.801 8.555 53.640 1.00 23.74 ? 302 CYS B O 1 ATOM 5203 C CB . CYS B 1 318 ? -36.951 7.689 52.661 1.00 15.63 ? 302 CYS B CB 1 ATOM 5204 S SG . CYS B 1 318 ? -35.625 6.483 52.436 1.00 15.18 ? 302 CYS B SG 1 ATOM 5205 N N . THR B 1 319 ? -38.338 9.830 54.781 1.00 21.57 ? 303 THR B N 1 ATOM 5206 C CA . THR B 1 319 ? -39.273 10.934 54.969 1.00 17.41 ? 303 THR B CA 1 ATOM 5207 C C . THR B 1 319 ? -38.963 12.079 54.011 1.00 16.82 ? 303 THR B C 1 ATOM 5208 O O . THR B 1 319 ? -39.868 12.761 53.527 1.00 19.62 ? 303 THR B O 1 ATOM 5209 C CB . THR B 1 319 ? -39.221 11.480 56.411 1.00 16.77 ? 303 THR B CB 1 ATOM 5210 O OG1 . THR B 1 319 ? -37.976 12.157 56.631 1.00 29.77 ? 303 THR B OG1 1 ATOM 5211 C CG2 . THR B 1 319 ? -39.378 10.352 57.422 1.00 17.08 ? 303 THR B CG2 1 ATOM 5212 N N . GLY B 1 320 ? -37.678 12.282 53.741 1.00 19.71 ? 304 GLY B N 1 ATOM 5213 C CA . GLY B 1 320 ? -37.227 13.392 52.923 1.00 17.70 ? 304 GLY B CA 1 ATOM 5214 C C . GLY B 1 320 ? -37.595 13.262 51.457 1.00 17.94 ? 304 GLY B C 1 ATOM 5215 O O . GLY B 1 320 ? -38.533 12.551 51.097 1.00 18.04 ? 304 GLY B O 1 ATOM 5216 N N . SER B 1 321 ? -36.840 13.955 50.610 1.00 15.00 ? 305 SER B N 1 ATOM 5217 C CA . SER B 1 321 ? -37.141 14.022 49.186 1.00 9.85 ? 305 SER B CA 1 ATOM 5218 C C . SER B 1 321 ? -36.137 13.233 48.358 1.00 13.93 ? 305 SER B C 1 ATOM 5219 O O . SER B 1 321 ? -35.032 12.939 48.813 1.00 14.02 ? 305 SER B O 1 ATOM 5220 C CB . SER B 1 321 ? -37.145 15.479 48.725 1.00 13.16 ? 305 SER B CB 1 ATOM 5221 O OG . SER B 1 321 ? -38.170 16.215 49.368 1.00 18.36 ? 305 SER B OG 1 ATOM 5222 N N . PHE B 1 322 ? -36.537 12.893 47.137 1.00 15.99 ? 306 PHE B N 1 ATOM 5223 C CA . PHE B 1 322 ? -35.655 12.217 46.195 1.00 13.71 ? 306 PHE B CA 1 ATOM 5224 C C . PHE B 1 322 ? -35.477 13.070 44.942 1.00 12.07 ? 306 PHE B C 1 ATOM 5225 O O . PHE B 1 322 ? -36.292 13.948 44.656 1.00 14.41 ? 306 PHE B O 1 ATOM 5226 C CB . PHE B 1 322 ? -36.213 10.842 45.829 1.00 12.10 ? 306 PHE B CB 1 ATOM 5227 C CG . PHE B 1 322 ? -36.338 9.911 47.001 1.00 13.03 ? 306 PHE B CG 1 ATOM 5228 C CD1 . PHE B 1 322 ? -37.445 9.965 47.830 1.00 14.19 ? 306 PHE B CD1 1 ATOM 5229 C CD2 . PHE B 1 322 ? -35.347 8.984 47.275 1.00 8.41 ? 306 PHE B CD2 1 ATOM 5230 C CE1 . PHE B 1 322 ? -37.563 9.111 48.909 1.00 11.59 ? 306 PHE B CE1 1 ATOM 5231 C CE2 . PHE B 1 322 ? -35.459 8.128 48.353 1.00 8.86 ? 306 PHE B CE2 1 ATOM 5232 C CZ . PHE B 1 322 ? -36.568 8.192 49.171 1.00 12.58 ? 306 PHE B CZ 1 ATOM 5233 N N . LYS B 1 323 ? -34.407 12.803 44.202 1.00 15.31 ? 307 LYS B N 1 ATOM 5234 C CA . LYS B 1 323 ? -34.054 13.600 43.032 1.00 10.67 ? 307 LYS B CA 1 ATOM 5235 C C . LYS B 1 323 ? -33.730 12.703 41.842 1.00 9.75 ? 307 LYS B C 1 ATOM 5236 O O . LYS B 1 323 ? -33.042 11.696 41.986 1.00 8.87 ? 307 LYS B O 1 ATOM 5237 C CB . LYS B 1 323 ? -32.857 14.495 43.360 1.00 11.15 ? 307 LYS B CB 1 ATOM 5238 C CG . LYS B 1 323 ? -32.194 15.142 42.156 1.00 23.38 ? 307 LYS B CG 1 ATOM 5239 C CD . LYS B 1 323 ? -31.166 16.175 42.597 1.00 27.93 ? 307 LYS B CD 1 ATOM 5240 C CE . LYS B 1 323 ? -30.389 16.745 41.422 1.00 41.94 ? 307 LYS B CE 1 ATOM 5241 N NZ . LYS B 1 323 ? -29.227 15.891 41.050 1.00 35.70 ? 307 LYS B NZ 1 ATOM 5242 N N . LEU B 1 324 ? -34.226 13.077 40.667 1.00 12.72 ? 308 LEU B N 1 ATOM 5243 C CA . LEU B 1 324 ? -34.021 12.277 39.464 1.00 10.66 ? 308 LEU B CA 1 ATOM 5244 C C . LEU B 1 324 ? -32.628 12.513 38.886 1.00 13.61 ? 308 LEU B C 1 ATOM 5245 O O . LEU B 1 324 ? -32.316 13.608 38.418 1.00 15.50 ? 308 LEU B O 1 ATOM 5246 C CB . LEU B 1 324 ? -35.089 12.603 38.417 1.00 6.25 ? 308 LEU B CB 1 ATOM 5247 C CG . LEU B 1 324 ? -35.164 11.644 37.228 1.00 5.30 ? 308 LEU B CG 1 ATOM 5248 C CD1 . LEU B 1 324 ? -35.612 10.263 37.678 1.00 11.69 ? 308 LEU B CD1 1 ATOM 5249 C CD2 . LEU B 1 324 ? -36.098 12.181 36.157 1.00 9.94 ? 308 LEU B CD2 1 ATOM 5250 N N . GLU B 1 325 ? -31.798 11.475 38.920 1.00 12.52 ? 309 GLU B N 1 ATOM 5251 C CA . GLU B 1 325 ? -30.423 11.566 38.435 1.00 10.18 ? 309 GLU B CA 1 ATOM 5252 C C . GLU B 1 325 ? -30.373 11.680 36.918 1.00 9.46 ? 309 GLU B C 1 ATOM 5253 O O . GLU B 1 325 ? -29.646 12.507 36.373 1.00 10.26 ? 309 GLU B O 1 ATOM 5254 C CB . GLU B 1 325 ? -29.624 10.343 38.885 1.00 17.74 ? 309 GLU B CB 1 ATOM 5255 C CG . GLU B 1 325 ? -29.215 10.380 40.346 1.00 15.38 ? 309 GLU B CG 1 ATOM 5256 C CD . GLU B 1 325 ? -28.221 11.486 40.641 1.00 16.24 ? 309 GLU B CD 1 ATOM 5257 O OE1 . GLU B 1 325 ? -28.652 12.573 41.079 1.00 25.25 ? 309 GLU B OE1 1 ATOM 5258 O OE2 . GLU B 1 325 ? -27.009 11.269 40.432 1.00 16.99 ? 309 GLU B OE2 1 ATOM 5259 N N . LYS B 1 326 ? -31.144 10.836 36.244 1.00 11.64 ? 310 LYS B N 1 ATOM 5260 C CA . LYS B 1 326 ? -31.280 10.902 34.797 1.00 6.64 ? 310 LYS B CA 1 ATOM 5261 C C . LYS B 1 326 ? -32.675 10.419 34.433 1.00 8.34 ? 310 LYS B C 1 ATOM 5262 O O . LYS B 1 326 ? -33.351 9.798 35.253 1.00 11.87 ? 310 LYS B O 1 ATOM 5263 C CB . LYS B 1 326 ? -30.217 10.043 34.111 1.00 7.92 ? 310 LYS B CB 1 ATOM 5264 C CG . LYS B 1 326 ? -30.306 8.569 34.450 1.00 9.51 ? 310 LYS B CG 1 ATOM 5265 C CD . LYS B 1 326 ? -29.049 7.816 34.034 1.00 19.77 ? 310 LYS B CD 1 ATOM 5266 C CE . LYS B 1 326 ? -28.791 7.912 32.537 1.00 33.96 ? 310 LYS B CE 1 ATOM 5267 N NZ . LYS B 1 326 ? -27.740 6.953 32.094 1.00 43.85 ? 310 LYS B NZ 1 ATOM 5268 N N . GLU B 1 327 ? -33.115 10.703 33.212 1.00 5.91 ? 311 GLU B N 1 ATOM 5269 C CA . GLU B 1 327 ? -34.471 10.345 32.813 1.00 9.62 ? 311 GLU B CA 1 ATOM 5270 C C . GLU B 1 327 ? -34.665 8.833 32.852 1.00 9.17 ? 311 GLU B C 1 ATOM 5271 O O . GLU B 1 327 ? -33.712 8.069 32.693 1.00 16.14 ? 311 GLU B O 1 ATOM 5272 C CB . GLU B 1 327 ? -34.801 10.888 31.420 1.00 9.87 ? 311 GLU B CB 1 ATOM 5273 C CG . GLU B 1 327 ? -33.992 10.272 30.299 1.00 14.69 ? 311 GLU B CG 1 ATOM 5274 C CD . GLU B 1 327 ? -34.576 10.570 28.934 1.00 15.48 ? 311 GLU B CD 1 ATOM 5275 O OE1 . GLU B 1 327 ? -34.375 9.751 28.010 1.00 22.16 ? 311 GLU B OE1 1 ATOM 5276 O OE2 . GLU B 1 327 ? -35.236 11.621 28.787 1.00 18.58 ? 311 GLU B OE2 1 ATOM 5277 N N . VAL B 1 328 ? -35.906 8.412 33.071 1.00 9.09 ? 312 VAL B N 1 ATOM 5278 C CA . VAL B 1 328 ? -36.238 6.995 33.157 1.00 8.57 ? 312 VAL B CA 1 ATOM 5279 C C . VAL B 1 328 ? -35.885 6.292 31.852 1.00 9.86 ? 312 VAL B C 1 ATOM 5280 O O . VAL B 1 328 ? -36.077 6.846 30.770 1.00 9.66 ? 312 VAL B O 1 ATOM 5281 C CB . VAL B 1 328 ? -37.736 6.795 33.454 1.00 6.31 ? 312 VAL B CB 1 ATOM 5282 C CG1 . VAL B 1 328 ? -38.091 5.313 33.469 1.00 6.03 ? 312 VAL B CG1 1 ATOM 5283 C CG2 . VAL B 1 328 ? -38.106 7.448 34.778 1.00 8.48 ? 312 VAL B CG2 1 ATOM 5284 N N . ALA B 1 329 ? -35.368 5.072 31.961 1.00 8.80 ? 313 ALA B N 1 ATOM 5285 C CA . ALA B 1 329 ? -34.940 4.312 30.793 1.00 8.37 ? 313 ALA B CA 1 ATOM 5286 C C . ALA B 1 329 ? -35.643 2.962 30.735 1.00 9.15 ? 313 ALA B C 1 ATOM 5287 O O . ALA B 1 329 ? -35.806 2.292 31.753 1.00 9.65 ? 313 ALA B O 1 ATOM 5288 C CB . ALA B 1 329 ? -33.436 4.119 30.818 1.00 5.93 ? 313 ALA B CB 1 ATOM 5289 N N . GLU B 1 330 ? -36.051 2.565 29.534 1.00 9.89 ? 314 GLU B N 1 ATOM 5290 C CA . GLU B 1 330 ? -36.758 1.307 29.341 1.00 7.54 ? 314 GLU B CA 1 ATOM 5291 C C . GLU B 1 330 ? -35.801 0.172 28.998 1.00 7.76 ? 314 GLU B C 1 ATOM 5292 O O . GLU B 1 330 ? -34.739 0.395 28.415 1.00 12.24 ? 314 GLU B O 1 ATOM 5293 C CB . GLU B 1 330 ? -37.775 1.449 28.211 1.00 9.48 ? 314 GLU B CB 1 ATOM 5294 C CG . GLU B 1 330 ? -37.153 1.508 26.828 1.00 13.44 ? 314 GLU B CG 1 ATOM 5295 C CD . GLU B 1 330 ? -38.194 1.601 25.731 1.00 15.73 ? 314 GLU B CD 1 ATOM 5296 O OE1 . GLU B 1 330 ? -37.822 1.894 24.575 1.00 25.62 ? 314 GLU B OE1 1 ATOM 5297 O OE2 . GLU B 1 330 ? -39.388 1.382 26.028 1.00 13.26 ? 314 GLU B OE2 1 ATOM 5298 N N . THR B 1 331 ? -36.183 -1.046 29.369 1.00 12.93 ? 315 THR B N 1 ATOM 5299 C CA . THR B 1 331 ? -35.538 -2.240 28.846 1.00 8.28 ? 315 THR B CA 1 ATOM 5300 C C . THR B 1 331 ? -36.384 -2.712 27.673 1.00 11.51 ? 315 THR B C 1 ATOM 5301 O O . THR B 1 331 ? -37.302 -2.008 27.252 1.00 17.15 ? 315 THR B O 1 ATOM 5302 C CB . THR B 1 331 ? -35.453 -3.353 29.899 1.00 8.63 ? 315 THR B CB 1 ATOM 5303 O OG1 . THR B 1 331 ? -36.766 -3.846 30.192 1.00 11.33 ? 315 THR B OG1 1 ATOM 5304 C CG2 . THR B 1 331 ? -34.808 -2.834 31.175 1.00 11.71 ? 315 THR B CG2 1 ATOM 5305 N N . GLN B 1 332 ? -36.084 -3.892 27.144 1.00 12.10 ? 316 GLN B N 1 ATOM 5306 C CA . GLN B 1 332 ? -36.871 -4.436 26.045 1.00 11.60 ? 316 GLN B CA 1 ATOM 5307 C C . GLN B 1 332 ? -37.725 -5.618 26.488 1.00 10.06 ? 316 GLN B C 1 ATOM 5308 O O . GLN B 1 332 ? -38.308 -6.315 25.656 1.00 8.74 ? 316 GLN B O 1 ATOM 5309 C CB . GLN B 1 332 ? -35.961 -4.839 24.884 1.00 18.22 ? 316 GLN B CB 1 ATOM 5310 C CG . GLN B 1 332 ? -35.448 -3.654 24.079 1.00 18.61 ? 316 GLN B CG 1 ATOM 5311 C CD . GLN B 1 332 ? -36.574 -2.813 23.502 1.00 25.34 ? 316 GLN B CD 1 ATOM 5312 O OE1 . GLN B 1 332 ? -37.502 -3.339 22.886 1.00 23.39 ? 316 GLN B OE1 1 ATOM 5313 N NE2 . GLN B 1 332 ? -36.504 -1.502 23.710 1.00 20.92 ? 316 GLN B NE2 1 ATOM 5314 N N . HIS B 1 333 ? -37.808 -5.834 27.797 1.00 11.37 ? 317 HIS B N 1 ATOM 5315 C CA . HIS B 1 333 ? -38.642 -6.901 28.334 1.00 7.07 ? 317 HIS B CA 1 ATOM 5316 C C . HIS B 1 333 ? -39.641 -6.382 29.369 1.00 6.94 ? 317 HIS B C 1 ATOM 5317 O O . HIS B 1 333 ? -39.980 -7.081 30.323 1.00 7.18 ? 317 HIS B O 1 ATOM 5318 C CB . HIS B 1 333 ? -37.779 -8.024 28.918 1.00 8.28 ? 317 HIS B CB 1 ATOM 5319 C CG . HIS B 1 333 ? -36.833 -7.575 29.986 1.00 8.94 ? 317 HIS B CG 1 ATOM 5320 N ND1 . HIS B 1 333 ? -37.160 -7.593 31.325 1.00 11.15 ? 317 HIS B ND1 1 ATOM 5321 C CD2 . HIS B 1 333 ? -35.564 -7.105 29.916 1.00 8.41 ? 317 HIS B CD2 1 ATOM 5322 C CE1 . HIS B 1 333 ? -36.136 -7.150 32.033 1.00 11.21 ? 317 HIS B CE1 1 ATOM 5323 N NE2 . HIS B 1 333 ? -35.156 -6.847 31.200 1.00 11.96 ? 317 HIS B NE2 1 ATOM 5324 N N . GLY B 1 334 ? -40.102 -5.149 29.174 1.00 7.76 ? 318 GLY B N 1 ATOM 5325 C CA . GLY B 1 334 ? -41.230 -4.624 29.924 1.00 4.89 ? 318 GLY B CA 1 ATOM 5326 C C . GLY B 1 334 ? -40.909 -3.936 31.239 1.00 5.58 ? 318 GLY B C 1 ATOM 5327 O O . GLY B 1 334 ? -41.815 -3.659 32.024 1.00 4.22 ? 318 GLY B O 1 ATOM 5328 N N . THR B 1 335 ? -39.635 -3.650 31.484 1.00 10.27 ? 319 THR B N 1 ATOM 5329 C CA . THR B 1 335 ? -39.229 -3.009 32.732 1.00 6.89 ? 319 THR B CA 1 ATOM 5330 C C . THR B 1 335 ? -38.567 -1.659 32.471 1.00 9.57 ? 319 THR B C 1 ATOM 5331 O O . THR B 1 335 ? -38.098 -1.391 31.366 1.00 13.22 ? 319 THR B O 1 ATOM 5332 C CB . THR B 1 335 ? -38.257 -3.900 33.527 1.00 7.29 ? 319 THR B CB 1 ATOM 5333 O OG1 . THR B 1 335 ? -37.006 -3.985 32.834 1.00 10.27 ? 319 THR B OG1 1 ATOM 5334 C CG2 . THR B 1 335 ? -38.835 -5.296 33.707 1.00 4.19 ? 319 THR B CG2 1 ATOM 5335 N N . VAL B 1 336 ? -38.532 -0.814 33.499 1.00 13.37 ? 320 VAL B N 1 ATOM 5336 C CA . VAL B 1 336 ? -37.913 0.504 33.397 1.00 6.51 ? 320 VAL B CA 1 ATOM 5337 C C . VAL B 1 336 ? -36.933 0.719 34.544 1.00 8.18 ? 320 VAL B C 1 ATOM 5338 O O . VAL B 1 336 ? -37.192 0.311 35.676 1.00 9.63 ? 320 VAL B O 1 ATOM 5339 C CB . VAL B 1 336 ? -38.969 1.631 33.423 1.00 9.31 ? 320 VAL B CB 1 ATOM 5340 C CG1 . VAL B 1 336 ? -40.007 1.406 32.341 1.00 7.37 ? 320 VAL B CG1 1 ATOM 5341 C CG2 . VAL B 1 336 ? -39.640 1.716 34.787 1.00 6.72 ? 320 VAL B CG2 1 ATOM 5342 N N . LEU B 1 337 ? -35.809 1.365 34.247 1.00 10.88 ? 321 LEU B N 1 ATOM 5343 C CA . LEU B 1 337 ? -34.791 1.640 35.254 1.00 8.76 ? 321 LEU B CA 1 ATOM 5344 C C . LEU B 1 337 ? -34.897 3.088 35.716 1.00 6.88 ? 321 LEU B C 1 ATOM 5345 O O . LEU B 1 337 ? -34.865 4.011 34.903 1.00 6.95 ? 321 LEU B O 1 ATOM 5346 C CB . LEU B 1 337 ? -33.387 1.381 34.696 1.00 16.42 ? 321 LEU B CB 1 ATOM 5347 C CG . LEU B 1 337 ? -33.090 0.019 34.053 1.00 14.31 ? 321 LEU B CG 1 ATOM 5348 C CD1 . LEU B 1 337 ? -33.612 -1.124 34.910 1.00 9.48 ? 321 LEU B CD1 1 ATOM 5349 C CD2 . LEU B 1 337 ? -33.648 -0.065 32.640 1.00 13.52 ? 321 LEU B CD2 1 ATOM 5350 N N . VAL B 1 338 ? -35.028 3.277 37.024 1.00 8.94 ? 322 VAL B N 1 ATOM 5351 C CA . VAL B 1 338 ? -35.145 4.611 37.605 1.00 5.11 ? 322 VAL B CA 1 ATOM 5352 C C . VAL B 1 338 ? -34.006 4.873 38.583 1.00 5.58 ? 322 VAL B C 1 ATOM 5353 O O . VAL B 1 338 ? -33.822 4.130 39.544 1.00 8.88 ? 322 VAL B O 1 ATOM 5354 C CB . VAL B 1 338 ? -36.483 4.776 38.352 1.00 10.19 ? 322 VAL B CB 1 ATOM 5355 C CG1 . VAL B 1 338 ? -36.546 6.126 39.056 1.00 6.94 ? 322 VAL B CG1 1 ATOM 5356 C CG2 . VAL B 1 338 ? -37.654 4.610 37.394 1.00 5.54 ? 322 VAL B CG2 1 ATOM 5357 N N . GLN B 1 339 ? -33.246 5.937 38.336 1.00 9.50 ? 323 GLN B N 1 ATOM 5358 C CA . GLN B 1 339 ? -32.122 6.293 39.194 1.00 8.33 ? 323 GLN B CA 1 ATOM 5359 C C . GLN B 1 339 ? -32.405 7.602 39.924 1.00 11.72 ? 323 GLN B C 1 ATOM 5360 O O . GLN B 1 339 ? -32.743 8.609 39.303 1.00 11.01 ? 323 GLN B O 1 ATOM 5361 C CB . GLN B 1 339 ? -30.841 6.418 38.370 1.00 14.05 ? 323 GLN B CB 1 ATOM 5362 C CG . GLN B 1 339 ? -29.592 6.642 39.205 1.00 14.64 ? 323 GLN B CG 1 ATOM 5363 C CD . GLN B 1 339 ? -28.331 6.705 38.366 1.00 15.33 ? 323 GLN B CD 1 ATOM 5364 O OE1 . GLN B 1 339 ? -27.854 7.785 38.020 1.00 16.22 ? 323 GLN B OE1 1 ATOM 5365 N NE2 . GLN B 1 339 ? -27.784 5.541 38.034 1.00 11.61 ? 323 GLN B NE2 1 ATOM 5366 N N . VAL B 1 340 ? -32.267 7.581 41.247 1.00 15.70 ? 324 VAL B N 1 ATOM 5367 C CA . VAL B 1 340 ? -32.600 8.742 42.065 1.00 10.58 ? 324 VAL B CA 1 ATOM 5368 C C . VAL B 1 340 ? -31.613 8.949 43.213 1.00 10.73 ? 324 VAL B C 1 ATOM 5369 O O . VAL B 1 340 ? -30.850 8.047 43.564 1.00 7.50 ? 324 VAL B O 1 ATOM 5370 C CB . VAL B 1 340 ? -34.017 8.612 42.656 1.00 11.71 ? 324 VAL B CB 1 ATOM 5371 C CG1 . VAL B 1 340 ? -35.057 8.609 41.546 1.00 5.64 ? 324 VAL B CG1 1 ATOM 5372 C CG2 . VAL B 1 340 ? -34.128 7.348 43.502 1.00 12.80 ? 324 VAL B CG2 1 ATOM 5373 N N . LYS B 1 341 ? -31.640 10.146 43.793 1.00 12.15 ? 325 LYS B N 1 ATOM 5374 C CA . LYS B 1 341 ? -30.790 10.484 44.932 1.00 11.70 ? 325 LYS B CA 1 ATOM 5375 C C . LYS B 1 341 ? -31.623 11.053 46.078 1.00 14.39 ? 325 LYS B C 1 ATOM 5376 O O . LYS B 1 341 ? -32.478 11.912 45.867 1.00 14.11 ? 325 LYS B O 1 ATOM 5377 C CB . LYS B 1 341 ? -29.728 11.504 44.520 1.00 14.86 ? 325 LYS B CB 1 ATOM 5378 C CG . LYS B 1 341 ? -28.300 11.008 44.653 1.00 15.58 ? 325 LYS B CG 1 ATOM 5379 C CD . LYS B 1 341 ? -27.334 12.167 44.831 1.00 19.57 ? 325 LYS B CD 1 ATOM 5380 C CE . LYS B 1 341 ? -25.890 11.703 44.795 1.00 28.05 ? 325 LYS B CE 1 ATOM 5381 N NZ . LYS B 1 341 ? -24.942 12.823 45.051 1.00 22.53 ? 325 LYS B NZ 1 ATOM 5382 N N . TYR B 1 342 ? -31.360 10.576 47.291 1.00 15.75 ? 326 TYR B N 1 ATOM 5383 C CA . TYR B 1 342 ? -32.104 11.007 48.471 1.00 12.66 ? 326 TYR B CA 1 ATOM 5384 C C . TYR B 1 342 ? -31.569 12.332 49.005 1.00 18.85 ? 326 TYR B C 1 ATOM 5385 O O . TYR B 1 342 ? -30.377 12.619 48.889 1.00 16.07 ? 326 TYR B O 1 ATOM 5386 C CB . TYR B 1 342 ? -32.027 9.929 49.554 1.00 12.30 ? 326 TYR B CB 1 ATOM 5387 C CG . TYR B 1 342 ? -32.951 10.156 50.730 1.00 11.49 ? 326 TYR B CG 1 ATOM 5388 C CD1 . TYR B 1 342 ? -34.287 10.480 50.536 1.00 12.22 ? 326 TYR B CD1 1 ATOM 5389 C CD2 . TYR B 1 342 ? -32.492 10.027 52.033 1.00 15.58 ? 326 TYR B CD2 1 ATOM 5390 C CE1 . TYR B 1 342 ? -35.136 10.685 51.607 1.00 13.59 ? 326 TYR B CE1 1 ATOM 5391 C CE2 . TYR B 1 342 ? -33.334 10.227 53.110 1.00 12.96 ? 326 TYR B CE2 1 ATOM 5392 C CZ . TYR B 1 342 ? -34.654 10.554 52.893 1.00 13.55 ? 326 TYR B CZ 1 ATOM 5393 O OH . TYR B 1 342 ? -35.490 10.752 53.967 1.00 16.06 ? 326 TYR B OH 1 ATOM 5394 N N . GLU B 1 343 ? -32.455 13.134 49.589 1.00 19.75 ? 327 GLU B N 1 ATOM 5395 C CA . GLU B 1 343 ? -32.082 14.451 50.095 1.00 15.02 ? 327 GLU B CA 1 ATOM 5396 C C . GLU B 1 343 ? -32.396 14.622 51.582 1.00 18.79 ? 327 GLU B C 1 ATOM 5397 O O . GLU B 1 343 ? -32.042 15.638 52.181 1.00 30.98 ? 327 GLU B O 1 ATOM 5398 C CB . GLU B 1 343 ? -32.808 15.537 49.303 1.00 16.76 ? 327 GLU B CB 1 ATOM 5399 C CG . GLU B 1 343 ? -32.603 15.456 47.806 1.00 19.69 ? 327 GLU B CG 1 ATOM 5400 C CD . GLU B 1 343 ? -33.346 16.553 47.073 1.00 20.70 ? 327 GLU B CD 1 ATOM 5401 O OE1 . GLU B 1 343 ? -32.698 17.319 46.329 1.00 35.42 ? 327 GLU B OE1 1 ATOM 5402 O OE2 . GLU B 1 343 ? -34.581 16.649 47.243 1.00 24.12 ? 327 GLU B OE2 1 ATOM 5403 N N . GLY B 1 344 ? -33.061 13.634 52.172 1.00 23.74 ? 328 GLY B N 1 ATOM 5404 C CA . GLY B 1 344 ? -33.462 13.710 53.567 1.00 20.83 ? 328 GLY B CA 1 ATOM 5405 C C . GLY B 1 344 ? -32.298 13.639 54.537 1.00 20.40 ? 328 GLY B C 1 ATOM 5406 O O . GLY B 1 344 ? -31.201 14.114 54.240 1.00 25.07 ? 328 GLY B O 1 ATOM 5407 N N . THR B 1 345 ? -32.535 13.044 55.703 1.00 22.42 ? 329 THR B N 1 ATOM 5408 C CA . THR B 1 345 ? -31.503 12.942 56.729 1.00 18.01 ? 329 THR B CA 1 ATOM 5409 C C . THR B 1 345 ? -31.564 11.624 57.499 1.00 19.44 ? 329 THR B C 1 ATOM 5410 O O . THR B 1 345 ? -30.800 11.419 58.442 1.00 19.85 ? 329 THR B O 1 ATOM 5411 C CB . THR B 1 345 ? -31.635 14.085 57.755 1.00 20.37 ? 329 THR B CB 1 ATOM 5412 O OG1 . THR B 1 345 ? -32.834 13.908 58.519 1.00 22.40 ? 329 THR B OG1 1 ATOM 5413 C CG2 . THR B 1 345 ? -31.673 15.431 57.057 1.00 22.06 ? 329 THR B CG2 1 ATOM 5414 N N . ASP B 1 346 ? -32.453 10.725 57.089 1.00 24.21 ? 330 ASP B N 1 ATOM 5415 C CA . ASP B 1 346 ? -32.743 9.534 57.880 1.00 14.05 ? 330 ASP B CA 1 ATOM 5416 C C . ASP B 1 346 ? -32.188 8.259 57.253 1.00 16.36 ? 330 ASP B C 1 ATOM 5417 O O . ASP B 1 346 ? -32.737 7.176 57.444 1.00 21.39 ? 330 ASP B O 1 ATOM 5418 C CB . ASP B 1 346 ? -34.252 9.398 58.110 1.00 16.99 ? 330 ASP B CB 1 ATOM 5419 C CG . ASP B 1 346 ? -35.061 9.612 56.845 1.00 13.70 ? 330 ASP B CG 1 ATOM 5420 O OD1 . ASP B 1 346 ? -34.599 10.357 55.957 1.00 13.80 ? 330 ASP B OD1 1 ATOM 5421 O OD2 . ASP B 1 346 ? -36.165 9.038 56.744 1.00 22.84 ? 330 ASP B OD2 1 ATOM 5422 N N . ALA B 1 347 ? -31.092 8.388 56.514 1.00 17.79 ? 331 ALA B N 1 ATOM 5423 C CA . ALA B 1 347 ? -30.442 7.225 55.928 1.00 21.70 ? 331 ALA B CA 1 ATOM 5424 C C . ALA B 1 347 ? -29.694 6.468 57.023 1.00 21.46 ? 331 ALA B C 1 ATOM 5425 O O . ALA B 1 347 ? -29.140 7.085 57.933 1.00 19.44 ? 331 ALA B O 1 ATOM 5426 C CB . ALA B 1 347 ? -29.489 7.648 54.820 1.00 17.28 ? 331 ALA B CB 1 ATOM 5427 N N . PRO B 1 348 ? -29.679 5.128 56.941 1.00 24.27 ? 332 PRO B N 1 ATOM 5428 C CA . PRO B 1 348 ? -30.302 4.373 55.852 1.00 15.69 ? 332 PRO B CA 1 ATOM 5429 C C . PRO B 1 348 ? -31.805 4.189 56.050 1.00 13.61 ? 332 PRO B C 1 ATOM 5430 O O . PRO B 1 348 ? -32.253 3.945 57.170 1.00 14.27 ? 332 PRO B O 1 ATOM 5431 C CB . PRO B 1 348 ? -29.581 3.027 55.919 1.00 20.56 ? 332 PRO B CB 1 ATOM 5432 C CG . PRO B 1 348 ? -29.264 2.857 57.363 1.00 20.24 ? 332 PRO B CG 1 ATOM 5433 C CD . PRO B 1 348 ? -28.990 4.242 57.898 1.00 20.24 ? 332 PRO B CD 1 ATOM 5434 N N . CYS B 1 349 ? -32.568 4.294 54.966 1.00 18.26 ? 333 CYS B N 1 ATOM 5435 C CA . CYS B 1 349 ? -34.023 4.198 55.038 1.00 16.21 ? 333 CYS B CA 1 ATOM 5436 C C . CYS B 1 349 ? -34.590 3.487 53.814 1.00 12.37 ? 333 CYS B C 1 ATOM 5437 O O . CYS B 1 349 ? -33.935 3.400 52.775 1.00 19.64 ? 333 CYS B O 1 ATOM 5438 C CB . CYS B 1 349 ? -34.647 5.591 55.175 1.00 13.44 ? 333 CYS B CB 1 ATOM 5439 S SG . CYS B 1 349 ? -34.202 6.747 53.860 1.00 13.40 ? 333 CYS B SG 1 ATOM 5440 N N . LYS B 1 350 ? -35.807 2.970 53.948 1.00 10.04 ? 334 LYS B N 1 ATOM 5441 C CA . LYS B 1 350 ? -36.468 2.259 52.860 1.00 8.61 ? 334 LYS B CA 1 ATOM 5442 C C . LYS B 1 350 ? -37.221 3.234 51.959 1.00 13.46 ? 334 LYS B C 1 ATOM 5443 O O . LYS B 1 350 ? -38.009 4.051 52.433 1.00 18.86 ? 334 LYS B O 1 ATOM 5444 C CB . LYS B 1 350 ? -37.423 1.209 53.429 1.00 13.51 ? 334 LYS B CB 1 ATOM 5445 C CG . LYS B 1 350 ? -37.882 0.161 52.429 1.00 20.33 ? 334 LYS B CG 1 ATOM 5446 C CD . LYS B 1 350 ? -38.513 -1.027 53.142 1.00 23.93 ? 334 LYS B CD 1 ATOM 5447 C CE . LYS B 1 350 ? -39.142 -2.005 52.165 1.00 29.82 ? 334 LYS B CE 1 ATOM 5448 N NZ . LYS B 1 350 ? -39.752 -3.169 52.867 1.00 32.52 ? 334 LYS B NZ 1 ATOM 5449 N N . ILE B 1 351 ? -36.970 3.138 50.657 1.00 13.93 ? 335 ILE B N 1 ATOM 5450 C CA . ILE B 1 351 ? -37.550 4.061 49.688 1.00 9.69 ? 335 ILE B CA 1 ATOM 5451 C C . ILE B 1 351 ? -39.017 3.743 49.415 1.00 10.26 ? 335 ILE B C 1 ATOM 5452 O O . ILE B 1 351 ? -39.345 2.632 48.996 1.00 12.89 ? 335 ILE B O 1 ATOM 5453 C CB . ILE B 1 351 ? -36.787 4.010 48.351 1.00 9.63 ? 335 ILE B CB 1 ATOM 5454 C CG1 . ILE B 1 351 ? -35.316 4.374 48.566 1.00 10.38 ? 335 ILE B CG1 1 ATOM 5455 C CG2 . ILE B 1 351 ? -37.429 4.950 47.338 1.00 9.56 ? 335 ILE B CG2 1 ATOM 5456 C CD1 . ILE B 1 351 ? -34.473 4.314 47.309 1.00 5.26 ? 335 ILE B CD1 1 ATOM 5457 N N . PRO B 1 352 ? -39.909 4.718 49.657 1.00 12.08 ? 336 PRO B N 1 ATOM 5458 C CA . PRO B 1 352 ? -41.327 4.551 49.318 1.00 8.80 ? 336 PRO B CA 1 ATOM 5459 C C . PRO B 1 352 ? -41.548 4.483 47.810 1.00 9.84 ? 336 PRO B C 1 ATOM 5460 O O . PRO B 1 352 ? -41.026 5.324 47.077 1.00 11.39 ? 336 PRO B O 1 ATOM 5461 C CB . PRO B 1 352 ? -41.978 5.817 49.890 1.00 8.52 ? 336 PRO B CB 1 ATOM 5462 C CG . PRO B 1 352 ? -41.016 6.330 50.903 1.00 8.25 ? 336 PRO B CG 1 ATOM 5463 C CD . PRO B 1 352 ? -39.664 5.977 50.380 1.00 11.01 ? 336 PRO B CD 1 ATOM 5464 N N . PHE B 1 353 ? -42.309 3.491 47.358 1.00 9.16 ? 337 PHE B N 1 ATOM 5465 C CA . PHE B 1 353 ? -42.600 3.328 45.938 1.00 8.59 ? 337 PHE B CA 1 ATOM 5466 C C . PHE B 1 353 ? -44.090 3.094 45.712 1.00 9.78 ? 337 PHE B C 1 ATOM 5467 O O . PHE B 1 353 ? -44.786 2.579 46.586 1.00 8.26 ? 337 PHE B O 1 ATOM 5468 C CB . PHE B 1 353 ? -41.801 2.157 45.364 1.00 14.06 ? 337 PHE B CB 1 ATOM 5469 C CG . PHE B 1 353 ? -42.188 1.789 43.959 1.00 11.04 ? 337 PHE B CG 1 ATOM 5470 C CD1 . PHE B 1 353 ? -43.217 0.894 43.722 1.00 15.41 ? 337 PHE B CD1 1 ATOM 5471 C CD2 . PHE B 1 353 ? -41.522 2.339 42.877 1.00 8.56 ? 337 PHE B CD2 1 ATOM 5472 C CE1 . PHE B 1 353 ? -43.575 0.553 42.431 1.00 9.69 ? 337 PHE B CE1 1 ATOM 5473 C CE2 . PHE B 1 353 ? -41.875 2.000 41.584 1.00 13.14 ? 337 PHE B CE2 1 ATOM 5474 C CZ . PHE B 1 353 ? -42.903 1.106 41.361 1.00 6.73 ? 337 PHE B CZ 1 ATOM 5475 N N . SER B 1 354 ? -44.572 3.472 44.532 1.00 10.20 ? 338 SER B N 1 ATOM 5476 C CA . SER B 1 354 ? -45.980 3.308 44.195 1.00 9.83 ? 338 SER B CA 1 ATOM 5477 C C . SER B 1 354 ? -46.189 3.400 42.687 1.00 10.83 ? 338 SER B C 1 ATOM 5478 O O . SER B 1 354 ? -45.479 4.128 41.993 1.00 10.41 ? 338 SER B O 1 ATOM 5479 C CB . SER B 1 354 ? -46.822 4.374 44.897 1.00 13.95 ? 338 SER B CB 1 ATOM 5480 O OG . SER B 1 354 ? -48.202 4.061 44.826 1.00 14.41 ? 338 SER B OG 1 ATOM 5481 N N . SER B 1 355 ? -47.174 2.660 42.187 1.00 13.79 ? 339 SER B N 1 ATOM 5482 C CA . SER B 1 355 ? -47.496 2.666 40.765 1.00 8.90 ? 339 SER B CA 1 ATOM 5483 C C . SER B 1 355 ? -48.982 2.931 40.550 1.00 12.54 ? 339 SER B C 1 ATOM 5484 O O . SER B 1 355 ? -49.828 2.317 41.197 1.00 14.45 ? 339 SER B O 1 ATOM 5485 C CB . SER B 1 355 ? -47.123 1.325 40.128 1.00 7.94 ? 339 SER B CB 1 ATOM 5486 O OG . SER B 1 355 ? -47.457 1.303 38.752 1.00 12.14 ? 339 SER B OG 1 ATOM 5487 N N . GLN B 1 356 ? -49.292 3.847 39.637 1.00 15.10 ? 340 GLN B N 1 ATOM 5488 C CA . GLN B 1 356 ? -50.676 4.113 39.258 1.00 14.74 ? 340 GLN B CA 1 ATOM 5489 C C . GLN B 1 356 ? -50.846 3.988 37.749 1.00 12.03 ? 340 GLN B C 1 ATOM 5490 O O . GLN B 1 356 ? -49.990 4.431 36.985 1.00 10.24 ? 340 GLN B O 1 ATOM 5491 C CB . GLN B 1 356 ? -51.113 5.505 39.716 1.00 19.38 ? 340 GLN B CB 1 ATOM 5492 C CG . GLN B 1 356 ? -51.487 5.589 41.189 1.00 21.29 ? 340 GLN B CG 1 ATOM 5493 C CD . GLN B 1 356 ? -50.319 5.980 42.069 1.00 20.93 ? 340 GLN B CD 1 ATOM 5494 O OE1 . GLN B 1 356 ? -49.914 5.228 42.955 1.00 27.66 ? 340 GLN B OE1 1 ATOM 5495 N NE2 . GLN B 1 356 ? -49.777 7.169 41.835 1.00 22.03 ? 340 GLN B NE2 1 ATOM 5496 N N . ASP B 1 357 ? -51.954 3.387 37.327 1.00 14.21 ? 341 ASP B N 1 ATOM 5497 C CA . ASP B 1 357 ? -52.192 3.140 35.912 1.00 15.68 ? 341 ASP B CA 1 ATOM 5498 C C . ASP B 1 357 ? -52.853 4.339 35.235 1.00 20.50 ? 341 ASP B C 1 ATOM 5499 O O . ASP B 1 357 ? -52.994 5.406 35.835 1.00 25.30 ? 341 ASP B O 1 ATOM 5500 C CB . ASP B 1 357 ? -53.051 1.886 35.728 1.00 21.95 ? 341 ASP B CB 1 ATOM 5501 C CG . ASP B 1 357 ? -54.427 2.019 36.354 1.00 20.79 ? 341 ASP B CG 1 ATOM 5502 O OD1 . ASP B 1 357 ? -54.833 3.154 36.679 1.00 22.42 ? 341 ASP B OD1 1 ATOM 5503 O OD2 . ASP B 1 357 ? -55.107 0.984 36.514 1.00 17.61 ? 341 ASP B OD2 1 ATOM 5504 N N . GLU B 1 358 ? -53.253 4.152 33.982 1.00 21.42 ? 342 GLU B N 1 ATOM 5505 C CA . GLU B 1 358 ? -53.909 5.202 33.208 1.00 19.09 ? 342 GLU B CA 1 ATOM 5506 C C . GLU B 1 358 ? -55.041 5.886 33.977 1.00 26.94 ? 342 GLU B C 1 ATOM 5507 O O . GLU B 1 358 ? -55.323 7.064 33.752 1.00 37.03 ? 342 GLU B O 1 ATOM 5508 C CB . GLU B 1 358 ? -54.461 4.632 31.896 1.00 17.76 ? 342 GLU B CB 1 ATOM 5509 C CG . GLU B 1 358 ? -55.456 3.496 32.074 1.00 27.49 ? 342 GLU B CG 1 ATOM 5510 C CD . GLU B 1 358 ? -54.792 2.131 32.086 1.00 33.46 ? 342 GLU B CD 1 ATOM 5511 O OE1 . GLU B 1 358 ? -55.179 1.285 32.921 1.00 33.79 ? 342 GLU B OE1 1 ATOM 5512 O OE2 . GLU B 1 358 ? -53.885 1.902 31.257 1.00 24.62 ? 342 GLU B OE2 1 ATOM 5513 N N . LYS B 1 359 ? -55.688 5.147 34.874 1.00 31.47 ? 343 LYS B N 1 ATOM 5514 C CA . LYS B 1 359 ? -56.854 5.658 35.590 1.00 32.85 ? 343 LYS B CA 1 ATOM 5515 C C . LYS B 1 359 ? -56.516 6.160 36.995 1.00 20.97 ? 343 LYS B C 1 ATOM 5516 O O . LYS B 1 359 ? -57.361 6.751 37.666 1.00 29.06 ? 343 LYS B O 1 ATOM 5517 C CB . LYS B 1 359 ? -57.927 4.585 35.659 1.00 27.76 ? 343 LYS B CB 1 ATOM 5518 N N . GLY B 1 360 ? -55.288 5.917 37.439 1.00 17.39 ? 344 GLY B N 1 ATOM 5519 C CA . GLY B 1 360 ? -54.845 6.383 38.742 1.00 24.51 ? 344 GLY B CA 1 ATOM 5520 C C . GLY B 1 360 ? -54.958 5.324 39.823 1.00 22.94 ? 344 GLY B C 1 ATOM 5521 O O . GLY B 1 360 ? -54.784 5.616 41.006 1.00 16.79 ? 344 GLY B O 1 ATOM 5522 N N . VAL B 1 361 ? -55.246 4.091 39.417 1.00 23.46 ? 345 VAL B N 1 ATOM 5523 C CA . VAL B 1 361 ? -55.382 2.984 40.359 1.00 20.39 ? 345 VAL B CA 1 ATOM 5524 C C . VAL B 1 361 ? -54.020 2.540 40.875 1.00 16.94 ? 345 VAL B C 1 ATOM 5525 O O . VAL B 1 361 ? -53.146 2.173 40.092 1.00 18.05 ? 345 VAL B O 1 ATOM 5526 C CB . VAL B 1 361 ? -56.071 1.768 39.701 1.00 25.78 ? 345 VAL B CB 1 ATOM 5527 C CG1 . VAL B 1 361 ? -56.140 0.594 40.674 1.00 24.45 ? 345 VAL B CG1 1 ATOM 5528 C CG2 . VAL B 1 361 ? -57.461 2.145 39.206 1.00 23.66 ? 345 VAL B CG2 1 ATOM 5529 N N . THR B 1 362 ? -53.844 2.568 42.192 1.00 18.08 ? 346 THR B N 1 ATOM 5530 C CA . THR B 1 362 ? -52.594 2.122 42.796 1.00 14.70 ? 346 THR B CA 1 ATOM 5531 C C . THR B 1 362 ? -52.472 0.608 42.646 1.00 15.96 ? 346 THR B C 1 ATOM 5532 O O . THR B 1 362 ? -53.410 -0.131 42.946 1.00 19.54 ? 346 THR B O 1 ATOM 5533 C CB . THR B 1 362 ? -52.511 2.508 44.283 1.00 12.53 ? 346 THR B CB 1 ATOM 5534 O OG1 . THR B 1 362 ? -52.887 3.882 44.446 1.00 15.56 ? 346 THR B OG1 1 ATOM 5535 C CG2 . THR B 1 362 ? -51.096 2.308 44.807 1.00 11.21 ? 346 THR B CG2 1 ATOM 5536 N N . GLN B 1 363 ? -51.311 0.154 42.186 1.00 13.73 ? 347 GLN B N 1 ATOM 5537 C CA . GLN B 1 363 ? -51.127 -1.242 41.802 1.00 12.01 ? 347 GLN B CA 1 ATOM 5538 C C . GLN B 1 363 ? -50.730 -2.145 42.967 1.00 11.34 ? 347 GLN B C 1 ATOM 5539 O O . GLN B 1 363 ? -50.999 -3.346 42.943 1.00 14.15 ? 347 GLN B O 1 ATOM 5540 C CB . GLN B 1 363 ? -50.067 -1.342 40.704 1.00 10.85 ? 347 GLN B CB 1 ATOM 5541 C CG . GLN B 1 363 ? -50.383 -0.524 39.464 1.00 11.83 ? 347 GLN B CG 1 ATOM 5542 C CD . GLN B 1 363 ? -51.622 -1.017 38.744 1.00 7.68 ? 347 GLN B CD 1 ATOM 5543 O OE1 . GLN B 1 363 ? -51.565 -1.971 37.968 1.00 8.19 ? 347 GLN B OE1 1 ATOM 5544 N NE2 . GLN B 1 363 ? -52.751 -0.371 39.002 1.00 9.86 ? 347 GLN B NE2 1 ATOM 5545 N N . ASN B 1 364 ? -50.093 -1.570 43.981 1.00 13.19 ? 348 ASN B N 1 ATOM 5546 C CA . ASN B 1 364 ? -49.562 -2.357 45.088 1.00 10.30 ? 348 ASN B CA 1 ATOM 5547 C C . ASN B 1 364 ? -48.710 -3.511 44.568 1.00 9.88 ? 348 ASN B C 1 ATOM 5548 O O . ASN B 1 364 ? -49.008 -4.679 44.815 1.00 12.82 ? 348 ASN B O 1 ATOM 5549 C CB . ASN B 1 364 ? -50.691 -2.903 45.964 1.00 11.01 ? 348 ASN B CB 1 ATOM 5550 C CG . ASN B 1 364 ? -51.555 -1.805 46.557 1.00 10.08 ? 348 ASN B CG 1 ATOM 5551 O OD1 . ASN B 1 364 ? -51.144 -1.107 47.483 1.00 20.35 ? 348 ASN B OD1 1 ATOM 5552 N ND2 . ASN B 1 364 ? -52.766 -1.657 46.032 1.00 10.83 ? 348 ASN B ND2 1 ATOM 5553 N N . GLY B 1 365 ? -47.651 -3.171 43.841 1.00 9.84 ? 349 GLY B N 1 ATOM 5554 C CA . GLY B 1 365 ? -46.774 -4.161 43.245 1.00 5.84 ? 349 GLY B CA 1 ATOM 5555 C C . GLY B 1 365 ? -45.959 -3.554 42.119 1.00 5.31 ? 349 GLY B C 1 ATOM 5556 O O . GLY B 1 365 ? -45.798 -2.336 42.050 1.00 9.92 ? 349 GLY B O 1 ATOM 5557 N N . ARG B 1 366 ? -45.441 -4.409 41.243 1.00 8.89 ? 350 ARG B N 1 ATOM 5558 C CA . ARG B 1 366 ? -44.700 -3.982 40.054 1.00 5.53 ? 350 ARG B CA 1 ATOM 5559 C C . ARG B 1 366 ? -43.303 -3.445 40.369 1.00 4.58 ? 350 ARG B C 1 ATOM 5560 O O . ARG B 1 366 ? -42.663 -2.832 39.515 1.00 5.83 ? 350 ARG B O 1 ATOM 5561 C CB . ARG B 1 366 ? -45.495 -2.944 39.254 1.00 8.82 ? 350 ARG B CB 1 ATOM 5562 C CG . ARG B 1 366 ? -46.798 -3.472 38.684 1.00 5.56 ? 350 ARG B CG 1 ATOM 5563 C CD . ARG B 1 366 ? -47.484 -2.419 37.839 1.00 3.77 ? 350 ARG B CD 1 ATOM 5564 N NE . ARG B 1 366 ? -48.726 -2.906 37.247 1.00 4.59 ? 350 ARG B NE 1 ATOM 5565 C CZ . ARG B 1 366 ? -48.793 -3.683 36.169 1.00 5.42 ? 350 ARG B CZ 1 ATOM 5566 N NH1 . ARG B 1 366 ? -47.687 -4.083 35.554 1.00 6.40 ? 350 ARG B NH1 1 ATOM 5567 N NH2 . ARG B 1 366 ? -49.972 -4.069 35.706 1.00 2.58 ? 350 ARG B NH2 1 ATOM 5568 N N . LEU B 1 367 ? -42.829 -3.684 41.587 1.00 5.24 ? 351 LEU B N 1 ATOM 5569 C CA . LEU B 1 367 ? -41.462 -3.330 41.951 1.00 3.82 ? 351 LEU B CA 1 ATOM 5570 C C . LEU B 1 367 ? -40.570 -4.560 41.827 1.00 4.80 ? 351 LEU B C 1 ATOM 5571 O O . LEU B 1 367 ? -40.836 -5.596 42.436 1.00 6.13 ? 351 LEU B O 1 ATOM 5572 C CB . LEU B 1 367 ? -41.404 -2.771 43.373 1.00 5.44 ? 351 LEU B CB 1 ATOM 5573 C CG . LEU B 1 367 ? -40.006 -2.419 43.892 1.00 7.92 ? 351 LEU B CG 1 ATOM 5574 C CD1 . LEU B 1 367 ? -39.387 -1.284 43.084 1.00 5.89 ? 351 LEU B CD1 1 ATOM 5575 C CD2 . LEU B 1 367 ? -40.056 -2.061 45.370 1.00 4.85 ? 351 LEU B CD2 1 ATOM 5576 N N . ILE B 1 368 ? -39.511 -4.439 41.033 1.00 7.92 ? 352 ILE B N 1 ATOM 5577 C CA . ILE B 1 368 ? -38.622 -5.564 40.763 1.00 7.07 ? 352 ILE B CA 1 ATOM 5578 C C . ILE B 1 368 ? -37.400 -5.554 41.682 1.00 11.06 ? 352 ILE B C 1 ATOM 5579 O O . ILE B 1 368 ? -36.832 -6.605 41.979 1.00 19.23 ? 352 ILE B O 1 ATOM 5580 C CB . ILE B 1 368 ? -38.171 -5.569 39.290 1.00 6.73 ? 352 ILE B CB 1 ATOM 5581 C CG1 . ILE B 1 368 ? -39.374 -5.837 38.383 1.00 6.19 ? 352 ILE B CG1 1 ATOM 5582 C CG2 . ILE B 1 368 ? -37.102 -6.624 39.059 1.00 9.51 ? 352 ILE B CG2 1 ATOM 5583 C CD1 . ILE B 1 368 ? -39.102 -5.637 36.909 1.00 4.57 ? 352 ILE B CD1 1 ATOM 5584 N N . THR B 1 369 ? -37.002 -4.371 42.136 1.00 11.10 ? 353 THR B N 1 ATOM 5585 C CA . THR B 1 369 ? -35.885 -4.251 43.065 1.00 12.25 ? 353 THR B CA 1 ATOM 5586 C C . THR B 1 369 ? -36.293 -4.774 44.439 1.00 15.28 ? 353 THR B C 1 ATOM 5587 O O . THR B 1 369 ? -37.285 -4.326 45.014 1.00 15.54 ? 353 THR B O 1 ATOM 5588 C CB . THR B 1 369 ? -35.412 -2.792 43.191 1.00 10.19 ? 353 THR B CB 1 ATOM 5589 O OG1 . THR B 1 369 ? -34.929 -2.334 41.922 1.00 9.32 ? 353 THR B OG1 1 ATOM 5590 C CG2 . THR B 1 369 ? -34.298 -2.671 44.222 1.00 18.03 ? 353 THR B CG2 1 ATOM 5591 N N . ALA B 1 370 ? -35.520 -5.721 44.960 1.00 20.98 ? 354 ALA B N 1 ATOM 5592 C CA . ALA B 1 370 ? -35.863 -6.392 46.209 1.00 18.11 ? 354 ALA B CA 1 ATOM 5593 C C . ALA B 1 370 ? -35.522 -5.542 47.429 1.00 19.81 ? 354 ALA B C 1 ATOM 5594 O O . ALA B 1 370 ? -36.286 -5.492 48.393 1.00 20.65 ? 354 ALA B O 1 ATOM 5595 C CB . ALA B 1 370 ? -35.155 -7.734 46.291 1.00 18.41 ? 354 ALA B CB 1 ATOM 5596 N N . ASN B 1 371 ? -34.373 -4.876 47.384 1.00 20.98 ? 355 ASN B N 1 ATOM 5597 C CA . ASN B 1 371 ? -33.917 -4.065 48.507 1.00 16.61 ? 355 ASN B CA 1 ATOM 5598 C C . ASN B 1 371 ? -33.896 -2.579 48.163 1.00 15.47 ? 355 ASN B C 1 ATOM 5599 O O . ASN B 1 371 ? -32.827 -1.991 47.993 1.00 23.52 ? 355 ASN B O 1 ATOM 5600 C CB . ASN B 1 371 ? -32.523 -4.512 48.947 1.00 16.05 ? 355 ASN B CB 1 ATOM 5601 C CG . ASN B 1 371 ? -32.342 -6.016 48.870 1.00 20.53 ? 355 ASN B CG 1 ATOM 5602 O OD1 . ASN B 1 371 ? -31.696 -6.527 47.955 1.00 19.91 ? 355 ASN B OD1 1 ATOM 5603 N ND2 . ASN B 1 371 ? -32.918 -6.733 49.828 1.00 17.47 ? 355 ASN B ND2 1 ATOM 5604 N N . PRO B 1 372 ? -35.084 -1.963 48.066 1.00 14.92 ? 356 PRO B N 1 ATOM 5605 C CA . PRO B 1 372 ? -35.180 -0.534 47.760 1.00 14.82 ? 356 PRO B CA 1 ATOM 5606 C C . PRO B 1 372 ? -34.793 0.311 48.969 1.00 11.22 ? 356 PRO B C 1 ATOM 5607 O O . PRO B 1 372 ? -35.658 0.920 49.597 1.00 11.53 ? 356 PRO B O 1 ATOM 5608 C CB . PRO B 1 372 ? -36.663 -0.355 47.432 1.00 11.53 ? 356 PRO B CB 1 ATOM 5609 C CG . PRO B 1 372 ? -37.344 -1.385 48.261 1.00 19.12 ? 356 PRO B CG 1 ATOM 5610 C CD . PRO B 1 372 ? -36.410 -2.566 48.294 1.00 18.12 ? 356 PRO B CD 1 ATOM 5611 N N . ILE B 1 373 ? -33.503 0.335 49.289 1.00 13.64 ? 357 ILE B N 1 ATOM 5612 C CA . ILE B 1 373 ? -33.024 1.007 50.490 1.00 14.79 ? 357 ILE B CA 1 ATOM 5613 C C . ILE B 1 373 ? -31.926 2.015 50.173 1.00 13.45 ? 357 ILE B C 1 ATOM 5614 O O . ILE B 1 373 ? -31.037 1.748 49.364 1.00 9.66 ? 357 ILE B O 1 ATOM 5615 C CB . ILE B 1 373 ? -32.451 -0.009 51.497 1.00 14.49 ? 357 ILE B CB 1 ATOM 5616 C CG1 . ILE B 1 373 ? -33.503 -1.059 51.864 1.00 12.27 ? 357 ILE B CG1 1 ATOM 5617 C CG2 . ILE B 1 373 ? -31.936 0.709 52.745 1.00 13.88 ? 357 ILE B CG2 1 ATOM 5618 C CD1 . ILE B 1 373 ? -34.297 -0.721 53.093 1.00 16.19 ? 357 ILE B CD1 1 ATOM 5619 N N . VAL B 1 374 ? -31.995 3.172 50.821 1.00 11.16 ? 358 VAL B N 1 ATOM 5620 C CA . VAL B 1 374 ? -30.917 4.146 50.767 1.00 13.32 ? 358 VAL B CA 1 ATOM 5621 C C . VAL B 1 374 ? -29.912 3.795 51.854 1.00 14.36 ? 358 VAL B C 1 ATOM 5622 O O . VAL B 1 374 ? -30.193 3.965 53.036 1.00 18.47 ? 358 VAL B O 1 ATOM 5623 C CB . VAL B 1 374 ? -31.432 5.574 51.019 1.00 14.97 ? 358 VAL B CB 1 ATOM 5624 C CG1 . VAL B 1 374 ? -30.295 6.577 50.911 1.00 14.08 ? 358 VAL B CG1 1 ATOM 5625 C CG2 . VAL B 1 374 ? -32.541 5.923 50.044 1.00 11.47 ? 358 VAL B CG2 1 ATOM 5626 N N . THR B 1 375 ? -28.748 3.294 51.457 1.00 13.67 ? 359 THR B N 1 ATOM 5627 C CA . THR B 1 375 ? -27.715 2.929 52.419 1.00 13.67 ? 359 THR B CA 1 ATOM 5628 C C . THR B 1 375 ? -26.768 4.099 52.647 1.00 17.76 ? 359 THR B C 1 ATOM 5629 O O . THR B 1 375 ? -26.160 4.223 53.710 1.00 17.58 ? 359 THR B O 1 ATOM 5630 C CB . THR B 1 375 ? -26.909 1.709 51.944 1.00 14.63 ? 359 THR B CB 1 ATOM 5631 O OG1 . THR B 1 375 ? -26.319 1.989 50.668 1.00 21.04 ? 359 THR B OG1 1 ATOM 5632 C CG2 . THR B 1 375 ? -27.808 0.484 51.831 1.00 10.08 ? 359 THR B CG2 1 ATOM 5633 N N . ASP B 1 376 ? -26.647 4.955 51.640 1.00 22.33 ? 360 ASP B N 1 ATOM 5634 C CA . ASP B 1 376 ? -25.795 6.131 51.737 1.00 19.05 ? 360 ASP B CA 1 ATOM 5635 C C . ASP B 1 376 ? -26.239 7.208 50.760 1.00 21.44 ? 360 ASP B C 1 ATOM 5636 O O . ASP B 1 376 ? -26.248 6.992 49.548 1.00 21.83 ? 360 ASP B O 1 ATOM 5637 C CB . ASP B 1 376 ? -24.341 5.757 51.448 1.00 23.63 ? 360 ASP B CB 1 ATOM 5638 C CG . ASP B 1 376 ? -23.418 6.962 51.440 1.00 21.51 ? 360 ASP B CG 1 ATOM 5639 O OD1 . ASP B 1 376 ? -23.559 7.829 52.327 1.00 24.88 ? 360 ASP B OD1 1 ATOM 5640 O OD2 . ASP B 1 376 ? -22.551 7.043 50.543 1.00 22.68 ? 360 ASP B OD2 1 ATOM 5641 N N . LYS B 1 377 ? -26.613 8.367 51.291 1.00 21.05 ? 361 LYS B N 1 ATOM 5642 C CA . LYS B 1 377 ? -26.838 9.532 50.452 1.00 22.45 ? 361 LYS B CA 1 ATOM 5643 C C . LYS B 1 377 ? -25.511 9.800 49.767 1.00 23.50 ? 361 LYS B C 1 ATOM 5644 O O . LYS B 1 377 ? -24.472 9.337 50.232 1.00 36.62 ? 361 LYS B O 1 ATOM 5645 C CB . LYS B 1 377 ? -27.255 10.741 51.283 1.00 27.05 ? 361 LYS B CB 1 ATOM 5646 C CG . LYS B 1 377 ? -28.464 10.508 52.169 1.00 26.88 ? 361 LYS B CG 1 ATOM 5647 C CD . LYS B 1 377 ? -28.465 11.476 53.335 1.00 27.86 ? 361 LYS B CD 1 ATOM 5648 C CE . LYS B 1 377 ? -28.537 12.916 52.865 1.00 29.20 ? 361 LYS B CE 1 ATOM 5649 N NZ . LYS B 1 377 ? -29.841 13.226 52.222 1.00 33.10 ? 361 LYS B NZ 1 ATOM 5650 N N . GLU B 1 378 ? -25.542 10.530 48.660 1.00 20.09 ? 362 GLU B N 1 ATOM 5651 C CA . GLU B 1 378 ? -24.357 10.712 47.829 1.00 24.34 ? 362 GLU B CA 1 ATOM 5652 C C . GLU B 1 378 ? -24.054 9.430 47.048 1.00 23.98 ? 362 GLU B C 1 ATOM 5653 O O . GLU B 1 378 ? -23.192 9.418 46.168 1.00 29.38 ? 362 GLU B O 1 ATOM 5654 C CB . GLU B 1 378 ? -23.148 11.140 48.670 1.00 19.12 ? 362 GLU B CB 1 ATOM 5655 N N . LYS B 1 379 ? -24.773 8.356 47.366 1.00 18.18 ? 363 LYS B N 1 ATOM 5656 C CA . LYS B 1 379 ? -24.688 7.120 46.601 1.00 21.03 ? 363 LYS B CA 1 ATOM 5657 C C . LYS B 1 379 ? -26.062 6.845 46.009 1.00 21.16 ? 363 LYS B C 1 ATOM 5658 O O . LYS B 1 379 ? -26.973 6.435 46.725 1.00 24.05 ? 363 LYS B O 1 ATOM 5659 C CB . LYS B 1 379 ? -24.266 5.955 47.496 1.00 24.22 ? 363 LYS B CB 1 ATOM 5660 C CG . LYS B 1 379 ? -23.172 5.086 46.901 1.00 22.00 ? 363 LYS B CG 1 ATOM 5661 C CD . LYS B 1 379 ? -23.345 3.623 47.281 1.00 27.14 ? 363 LYS B CD 1 ATOM 5662 C CE . LYS B 1 379 ? -24.200 2.878 46.260 1.00 26.79 ? 363 LYS B CE 1 ATOM 5663 N NZ . LYS B 1 379 ? -24.337 1.428 46.579 1.00 21.44 ? 363 LYS B NZ 1 ATOM 5664 N N . PRO B 1 380 ? -26.222 7.085 44.699 1.00 17.34 ? 364 PRO B N 1 ATOM 5665 C CA . PRO B 1 380 ? -27.533 6.947 44.055 1.00 16.91 ? 364 PRO B CA 1 ATOM 5666 C C . PRO B 1 380 ? -28.060 5.515 44.088 1.00 12.93 ? 364 PRO B C 1 ATOM 5667 O O . PRO B 1 380 ? -27.272 4.571 44.131 1.00 18.24 ? 364 PRO B O 1 ATOM 5668 C CB . PRO B 1 380 ? -27.265 7.391 42.614 1.00 20.48 ? 364 PRO B CB 1 ATOM 5669 C CG . PRO B 1 380 ? -25.808 7.174 42.411 1.00 23.12 ? 364 PRO B CG 1 ATOM 5670 C CD . PRO B 1 380 ? -25.167 7.441 43.735 1.00 19.27 ? 364 PRO B CD 1 ATOM 5671 N N . VAL B 1 381 ? -29.382 5.368 44.071 1.00 8.30 ? 365 VAL B N 1 ATOM 5672 C CA . VAL B 1 381 ? -30.012 4.054 44.110 1.00 12.71 ? 365 VAL B CA 1 ATOM 5673 C C . VAL B 1 381 ? -30.832 3.821 42.846 1.00 11.55 ? 365 VAL B C 1 ATOM 5674 O O . VAL B 1 381 ? -31.593 4.689 42.420 1.00 10.04 ? 365 VAL B O 1 ATOM 5675 C CB . VAL B 1 381 ? -30.932 3.913 45.338 1.00 14.17 ? 365 VAL B CB 1 ATOM 5676 C CG1 . VAL B 1 381 ? -31.495 2.503 45.421 1.00 10.23 ? 365 VAL B CG1 1 ATOM 5677 C CG2 . VAL B 1 381 ? -30.176 4.265 46.613 1.00 12.70 ? 365 VAL B CG2 1 ATOM 5678 N N . ASN B 1 382 ? -30.674 2.644 42.250 1.00 14.46 ? 366 ASN B N 1 ATOM 5679 C CA . ASN B 1 382 ? -31.396 2.300 41.031 1.00 8.60 ? 366 ASN B CA 1 ATOM 5680 C C . ASN B 1 382 ? -32.630 1.458 41.338 1.00 11.44 ? 366 ASN B C 1 ATOM 5681 O O . ASN B 1 382 ? -32.575 0.537 42.154 1.00 15.26 ? 366 ASN B O 1 ATOM 5682 C CB . ASN B 1 382 ? -30.475 1.557 40.064 1.00 14.07 ? 366 ASN B CB 1 ATOM 5683 C CG . ASN B 1 382 ? -29.147 2.262 39.872 1.00 6.91 ? 366 ASN B CG 1 ATOM 5684 O OD1 . ASN B 1 382 ? -29.041 3.208 39.093 1.00 10.40 ? 366 ASN B OD1 1 ATOM 5685 N ND2 . ASN B 1 382 ? -28.126 1.807 40.588 1.00 5.19 ? 366 ASN B ND2 1 ATOM 5686 N N . ILE B 1 383 ? -33.740 1.782 40.683 1.00 9.14 ? 367 ILE B N 1 ATOM 5687 C CA . ILE B 1 383 ? -35.009 1.119 40.945 1.00 8.97 ? 367 ILE B CA 1 ATOM 5688 C C . ILE B 1 383 ? -35.623 0.592 39.655 1.00 7.92 ? 367 ILE B C 1 ATOM 5689 O O . ILE B 1 383 ? -36.043 1.367 38.797 1.00 10.58 ? 367 ILE B O 1 ATOM 5690 C CB . ILE B 1 383 ? -36.011 2.085 41.598 1.00 6.00 ? 367 ILE B CB 1 ATOM 5691 C CG1 . ILE B 1 383 ? -35.472 2.588 42.938 1.00 4.63 ? 367 ILE B CG1 1 ATOM 5692 C CG2 . ILE B 1 383 ? -37.353 1.400 41.796 1.00 5.15 ? 367 ILE B CG2 1 ATOM 5693 C CD1 . ILE B 1 383 ? -35.750 4.053 43.188 1.00 6.94 ? 367 ILE B CD1 1 ATOM 5694 N N . GLU B 1 384 ? -35.681 -0.728 39.525 1.00 11.16 ? 368 GLU B N 1 ATOM 5695 C CA . GLU B 1 384 ? -36.317 -1.344 38.371 1.00 6.40 ? 368 GLU B CA 1 ATOM 5696 C C . GLU B 1 384 ? -37.776 -1.647 38.689 1.00 7.33 ? 368 GLU B C 1 ATOM 5697 O O . GLU B 1 384 ? -38.090 -2.215 39.735 1.00 9.94 ? 368 GLU B O 1 ATOM 5698 C CB . GLU B 1 384 ? -35.593 -2.628 37.966 1.00 6.13 ? 368 GLU B CB 1 ATOM 5699 C CG . GLU B 1 384 ? -36.109 -3.229 36.666 1.00 8.42 ? 368 GLU B CG 1 ATOM 5700 C CD . GLU B 1 384 ? -35.332 -4.455 36.232 1.00 14.26 ? 368 GLU B CD 1 ATOM 5701 O OE1 . GLU B 1 384 ? -34.567 -4.999 37.056 1.00 18.02 ? 368 GLU B OE1 1 ATOM 5702 O OE2 . GLU B 1 384 ? -35.489 -4.876 35.067 1.00 12.04 ? 368 GLU B OE2 1 ATOM 5703 N N . ALA B 1 385 ? -38.665 -1.251 37.784 1.00 6.00 ? 369 ALA B N 1 ATOM 5704 C CA . ALA B 1 385 ? -40.092 -1.487 37.951 1.00 3.09 ? 369 ALA B CA 1 ATOM 5705 C C . ALA B 1 385 ? -40.669 -2.084 36.674 1.00 4.98 ? 369 ALA B C 1 ATOM 5706 O O . ALA B 1 385 ? -39.988 -2.152 35.651 1.00 5.15 ? 369 ALA B O 1 ATOM 5707 C CB . ALA B 1 385 ? -40.800 -0.188 38.291 1.00 5.18 ? 369 ALA B CB 1 ATOM 5708 N N . GLU B 1 386 ? -41.924 -2.518 36.739 1.00 6.05 ? 370 GLU B N 1 ATOM 5709 C CA . GLU B 1 386 ? -42.624 -3.021 35.564 1.00 3.77 ? 370 GLU B CA 1 ATOM 5710 C C . GLU B 1 386 ? -43.955 -2.303 35.418 1.00 4.55 ? 370 GLU B C 1 ATOM 5711 O O . GLU B 1 386 ? -44.978 -2.779 35.909 1.00 8.11 ? 370 GLU B O 1 ATOM 5712 C CB . GLU B 1 386 ? -42.856 -4.529 35.670 1.00 6.84 ? 370 GLU B CB 1 ATOM 5713 C CG . GLU B 1 386 ? -43.634 -5.111 34.497 1.00 8.68 ? 370 GLU B CG 1 ATOM 5714 C CD . GLU B 1 386 ? -43.643 -6.624 34.497 1.00 6.50 ? 370 GLU B CD 1 ATOM 5715 O OE1 . GLU B 1 386 ? -43.316 -7.219 35.544 1.00 7.27 ? 370 GLU B OE1 1 ATOM 5716 O OE2 . GLU B 1 386 ? -43.978 -7.218 33.451 1.00 10.38 ? 370 GLU B OE2 1 ATOM 5717 N N . PRO B 1 387 ? -43.944 -1.147 34.739 1.00 9.60 ? 371 PRO B N 1 ATOM 5718 C CA . PRO B 1 387 ? -45.145 -0.318 34.595 1.00 6.56 ? 371 PRO B CA 1 ATOM 5719 C C . PRO B 1 387 ? -46.254 -1.035 33.837 1.00 6.28 ? 371 PRO B C 1 ATOM 5720 O O . PRO B 1 387 ? -45.961 -1.869 32.981 1.00 9.13 ? 371 PRO B O 1 ATOM 5721 C CB . PRO B 1 387 ? -44.650 0.883 33.776 1.00 8.03 ? 371 PRO B CB 1 ATOM 5722 C CG . PRO B 1 387 ? -43.164 0.863 33.893 1.00 5.34 ? 371 PRO B CG 1 ATOM 5723 C CD . PRO B 1 387 ? -42.791 -0.571 34.029 1.00 6.37 ? 371 PRO B CD 1 ATOM 5724 N N . PRO B 1 388 ? -47.519 -0.724 34.156 1.00 5.01 ? 372 PRO B N 1 ATOM 5725 C CA . PRO B 1 388 ? -48.637 -1.240 33.360 1.00 6.51 ? 372 PRO B CA 1 ATOM 5726 C C . PRO B 1 388 ? -48.602 -0.680 31.944 1.00 3.76 ? 372 PRO B C 1 ATOM 5727 O O . PRO B 1 388 ? -48.050 0.398 31.730 1.00 6.87 ? 372 PRO B O 1 ATOM 5728 C CB . PRO B 1 388 ? -49.872 -0.725 34.108 1.00 8.11 ? 372 PRO B CB 1 ATOM 5729 C CG . PRO B 1 388 ? -49.386 0.420 34.926 1.00 4.77 ? 372 PRO B CG 1 ATOM 5730 C CD . PRO B 1 388 ? -47.978 0.092 35.292 1.00 4.74 ? 372 PRO B CD 1 ATOM 5731 N N . PHE B 1 389 ? -49.177 -1.405 30.991 1.00 7.78 ? 373 PHE B N 1 ATOM 5732 C CA . PHE B 1 389 ? -49.224 -0.936 29.611 1.00 6.79 ? 373 PHE B CA 1 ATOM 5733 C C . PHE B 1 389 ? -50.023 0.357 29.516 1.00 10.70 ? 373 PHE B C 1 ATOM 5734 O O . PHE B 1 389 ? -50.970 0.570 30.274 1.00 14.73 ? 373 PHE B O 1 ATOM 5735 C CB . PHE B 1 389 ? -49.835 -1.999 28.696 1.00 3.54 ? 373 PHE B CB 1 ATOM 5736 C CG . PHE B 1 389 ? -48.894 -3.119 28.351 1.00 5.16 ? 373 PHE B CG 1 ATOM 5737 C CD1 . PHE B 1 389 ? -47.919 -2.948 27.382 1.00 6.81 ? 373 PHE B CD1 1 ATOM 5738 C CD2 . PHE B 1 389 ? -48.989 -4.346 28.987 1.00 6.54 ? 373 PHE B CD2 1 ATOM 5739 C CE1 . PHE B 1 389 ? -47.053 -3.976 27.060 1.00 4.24 ? 373 PHE B CE1 1 ATOM 5740 C CE2 . PHE B 1 389 ? -48.126 -5.377 28.667 1.00 5.16 ? 373 PHE B CE2 1 ATOM 5741 C CZ . PHE B 1 389 ? -47.158 -5.191 27.701 1.00 4.39 ? 373 PHE B CZ 1 ATOM 5742 N N . GLY B 1 390 ? -49.632 1.220 28.584 1.00 6.67 ? 374 GLY B N 1 ATOM 5743 C CA . GLY B 1 390 ? -50.287 2.502 28.403 1.00 7.05 ? 374 GLY B CA 1 ATOM 5744 C C . GLY B 1 390 ? -49.707 3.567 29.313 1.00 5.14 ? 374 GLY B C 1 ATOM 5745 O O . GLY B 1 390 ? -48.523 3.531 29.646 1.00 6.88 ? 374 GLY B O 1 ATOM 5746 N N . GLU B 1 391 ? -50.547 4.515 29.716 1.00 6.54 ? 375 GLU B N 1 ATOM 5747 C CA . GLU B 1 391 ? -50.120 5.604 30.587 1.00 7.63 ? 375 GLU B CA 1 ATOM 5748 C C . GLU B 1 391 ? -50.078 5.163 32.046 1.00 12.56 ? 375 GLU B C 1 ATOM 5749 O O . GLU B 1 391 ? -50.973 4.461 32.519 1.00 9.86 ? 375 GLU B O 1 ATOM 5750 C CB . GLU B 1 391 ? -51.062 6.800 30.440 1.00 17.65 ? 375 GLU B CB 1 ATOM 5751 C CG . GLU B 1 391 ? -50.932 7.538 29.116 1.00 18.10 ? 375 GLU B CG 1 ATOM 5752 C CD . GLU B 1 391 ? -51.916 8.686 28.986 1.00 23.93 ? 375 GLU B CD 1 ATOM 5753 O OE1 . GLU B 1 391 ? -51.944 9.328 27.915 1.00 23.68 ? 375 GLU B OE1 1 ATOM 5754 O OE2 . GLU B 1 391 ? -52.659 8.949 29.955 1.00 27.52 ? 375 GLU B OE2 1 ATOM 5755 N N . SER B 1 392 ? -49.035 5.583 32.755 1.00 9.58 ? 376 SER B N 1 ATOM 5756 C CA . SER B 1 392 ? -48.896 5.270 34.172 1.00 7.23 ? 376 SER B CA 1 ATOM 5757 C C . SER B 1 392 ? -47.943 6.250 34.849 1.00 6.72 ? 376 SER B C 1 ATOM 5758 O O . SER B 1 392 ? -47.217 6.984 34.179 1.00 8.45 ? 376 SER B O 1 ATOM 5759 C CB . SER B 1 392 ? -48.392 3.837 34.351 1.00 4.95 ? 376 SER B CB 1 ATOM 5760 O OG . SER B 1 392 ? -47.032 3.708 33.973 1.00 8.38 ? 376 SER B OG 1 ATOM 5761 N N . TYR B 1 393 ? -47.958 6.263 36.179 1.00 6.44 ? 377 TYR B N 1 ATOM 5762 C CA . TYR B 1 393 ? -47.044 7.102 36.947 1.00 7.00 ? 377 TYR B CA 1 ATOM 5763 C C . TYR B 1 393 ? -46.197 6.272 37.908 1.00 9.98 ? 377 TYR B C 1 ATOM 5764 O O . TYR B 1 393 ? -46.680 5.311 38.508 1.00 8.19 ? 377 TYR B O 1 ATOM 5765 C CB . TYR B 1 393 ? -47.820 8.157 37.739 1.00 9.08 ? 377 TYR B CB 1 ATOM 5766 C CG . TYR B 1 393 ? -48.300 9.336 36.919 1.00 12.66 ? 377 TYR B CG 1 ATOM 5767 C CD1 . TYR B 1 393 ? -47.438 10.376 36.596 1.00 11.12 ? 377 TYR B CD1 1 ATOM 5768 C CD2 . TYR B 1 393 ? -49.616 9.419 36.483 1.00 4.94 ? 377 TYR B CD2 1 ATOM 5769 C CE1 . TYR B 1 393 ? -47.869 11.458 35.853 1.00 7.08 ? 377 TYR B CE1 1 ATOM 5770 C CE2 . TYR B 1 393 ? -50.056 10.499 35.739 1.00 6.72 ? 377 TYR B CE2 1 ATOM 5771 C CZ . TYR B 1 393 ? -49.178 11.515 35.428 1.00 10.09 ? 377 TYR B CZ 1 ATOM 5772 O OH . TYR B 1 393 ? -49.610 12.593 34.688 1.00 22.17 ? 377 TYR B OH 1 ATOM 5773 N N . ILE B 1 394 ? -44.930 6.652 38.041 1.00 10.28 ? 378 ILE B N 1 ATOM 5774 C CA . ILE B 1 394 ? -44.031 6.053 39.019 1.00 6.95 ? 378 ILE B CA 1 ATOM 5775 C C . ILE B 1 394 ? -43.743 7.073 40.112 1.00 7.42 ? 378 ILE B C 1 ATOM 5776 O O . ILE B 1 394 ? -43.164 8.124 39.844 1.00 9.83 ? 378 ILE B O 1 ATOM 5777 C CB . ILE B 1 394 ? -42.701 5.645 38.371 1.00 8.45 ? 378 ILE B CB 1 ATOM 5778 C CG1 . ILE B 1 394 ? -42.924 4.519 37.362 1.00 7.48 ? 378 ILE B CG1 1 ATOM 5779 C CG2 . ILE B 1 394 ? -41.707 5.206 39.432 1.00 11.33 ? 378 ILE B CG2 1 ATOM 5780 C CD1 . ILE B 1 394 ? -41.872 4.464 36.277 1.00 9.27 ? 378 ILE B CD1 1 ATOM 5781 N N . VAL B 1 395 ? -44.140 6.765 41.342 1.00 9.14 ? 379 VAL B N 1 ATOM 5782 C CA . VAL B 1 395 ? -43.952 7.698 42.447 1.00 8.35 ? 379 VAL B CA 1 ATOM 5783 C C . VAL B 1 395 ? -42.859 7.224 43.396 1.00 9.96 ? 379 VAL B C 1 ATOM 5784 O O . VAL B 1 395 ? -42.940 6.135 43.963 1.00 10.75 ? 379 VAL B O 1 ATOM 5785 C CB . VAL B 1 395 ? -45.251 7.899 43.245 1.00 7.85 ? 379 VAL B CB 1 ATOM 5786 C CG1 . VAL B 1 395 ? -45.079 9.019 44.257 1.00 6.04 ? 379 VAL B CG1 1 ATOM 5787 C CG2 . VAL B 1 395 ? -46.399 8.214 42.307 1.00 6.75 ? 379 VAL B CG2 1 ATOM 5788 N N . VAL B 1 396 ? -41.835 8.056 43.560 1.00 13.36 ? 380 VAL B N 1 ATOM 5789 C CA . VAL B 1 396 ? -40.739 7.763 44.473 1.00 14.23 ? 380 VAL B CA 1 ATOM 5790 C C . VAL B 1 396 ? -40.763 8.745 45.639 1.00 10.29 ? 380 VAL B C 1 ATOM 5791 O O . VAL B 1 396 ? -40.889 9.952 45.439 1.00 16.46 ? 380 VAL B O 1 ATOM 5792 C CB . VAL B 1 396 ? -39.378 7.862 43.759 1.00 14.37 ? 380 VAL B CB 1 ATOM 5793 C CG1 . VAL B 1 396 ? -38.241 7.597 44.735 1.00 10.91 ? 380 VAL B CG1 1 ATOM 5794 C CG2 . VAL B 1 396 ? -39.323 6.891 42.587 1.00 7.37 ? 380 VAL B CG2 1 ATOM 5795 N N . GLY B 1 397 ? -40.645 8.222 46.855 1.00 7.88 ? 381 GLY B N 1 ATOM 5796 C CA . GLY B 1 397 ? -40.688 9.050 48.045 1.00 11.78 ? 381 GLY B CA 1 ATOM 5797 C C . GLY B 1 397 ? -42.112 9.327 48.485 1.00 11.83 ? 381 GLY B C 1 ATOM 5798 O O . GLY B 1 397 ? -43.054 9.158 47.710 1.00 15.78 ? 381 GLY B O 1 ATOM 5799 N N . ALA B 1 398 ? -42.266 9.758 49.733 1.00 17.79 ? 382 ALA B N 1 ATOM 5800 C CA . ALA B 1 398 ? -43.584 9.980 50.316 1.00 22.73 ? 382 ALA B CA 1 ATOM 5801 C C . ALA B 1 398 ? -43.887 11.469 50.459 1.00 24.80 ? 382 ALA B C 1 ATOM 5802 O O . ALA B 1 398 ? -43.074 12.318 50.090 1.00 23.54 ? 382 ALA B O 1 ATOM 5803 C CB . ALA B 1 398 ? -43.676 9.292 51.668 1.00 21.70 ? 382 ALA B CB 1 ATOM 5804 N N . GLY B 1 399 ? -45.062 11.776 51.001 1.00 23.13 ? 383 GLY B N 1 ATOM 5805 C CA . GLY B 1 399 ? -45.484 13.151 51.190 1.00 32.87 ? 383 GLY B CA 1 ATOM 5806 C C . GLY B 1 399 ? -45.856 13.814 49.880 1.00 31.09 ? 383 GLY B C 1 ATOM 5807 O O . GLY B 1 399 ? -45.619 13.265 48.805 1.00 35.91 ? 383 GLY B O 1 ATOM 5808 N N . GLU B 1 400 ? -46.439 15.005 49.971 1.00 22.22 ? 384 GLU B N 1 ATOM 5809 C CA . GLU B 1 400 ? -46.809 15.766 48.785 1.00 21.67 ? 384 GLU B CA 1 ATOM 5810 C C . GLU B 1 400 ? -45.572 16.229 48.021 1.00 22.78 ? 384 GLU B C 1 ATOM 5811 O O . GLU B 1 400 ? -45.679 16.745 46.909 1.00 29.98 ? 384 GLU B O 1 ATOM 5812 C CB . GLU B 1 400 ? -47.671 16.968 49.174 1.00 25.11 ? 384 GLU B CB 1 ATOM 5813 C CG . GLU B 1 400 ? -49.089 16.602 49.599 1.00 16.39 ? 384 GLU B CG 1 ATOM 5814 C CD . GLU B 1 400 ? -50.016 16.357 48.420 1.00 15.56 ? 384 GLU B CD 1 ATOM 5815 O OE1 . GLU B 1 400 ? -49.647 16.720 47.283 1.00 20.82 ? 384 GLU B OE1 1 ATOM 5816 O OE2 . GLU B 1 400 ? -51.111 15.794 48.630 1.00 2.77 ? 384 GLU B OE2 1 ATOM 5817 N N . LYS B 1 401 ? -44.400 16.040 48.620 1.00 24.37 ? 385 LYS B N 1 ATOM 5818 C CA . LYS B 1 401 ? -43.143 16.373 47.961 1.00 27.44 ? 385 LYS B CA 1 ATOM 5819 C C . LYS B 1 401 ? -42.613 15.187 47.155 1.00 28.05 ? 385 LYS B C 1 ATOM 5820 O O . LYS B 1 401 ? -41.520 15.250 46.593 1.00 20.86 ? 385 LYS B O 1 ATOM 5821 C CB . LYS B 1 401 ? -42.116 16.811 48.989 1.00 23.47 ? 385 LYS B CB 1 ATOM 5822 N N . ALA B 1 402 ? -43.396 14.113 47.098 1.00 30.70 ? 386 ALA B N 1 ATOM 5823 C CA . ALA B 1 402 ? -42.994 12.900 46.391 1.00 17.20 ? 386 ALA B CA 1 ATOM 5824 C C . ALA B 1 402 ? -42.640 13.195 44.936 1.00 21.35 ? 386 ALA B C 1 ATOM 5825 O O . ALA B 1 402 ? -43.157 14.138 44.337 1.00 28.39 ? 386 ALA B O 1 ATOM 5826 C CB . ALA B 1 402 ? -44.102 11.858 46.462 1.00 15.00 ? 386 ALA B CB 1 ATOM 5827 N N . LEU B 1 403 ? -41.753 12.377 44.380 1.00 19.96 ? 387 LEU B N 1 ATOM 5828 C CA . LEU B 1 403 ? -41.331 12.513 42.992 1.00 12.82 ? 387 LEU B CA 1 ATOM 5829 C C . LEU B 1 403 ? -42.242 11.688 42.091 1.00 9.52 ? 387 LEU B C 1 ATOM 5830 O O . LEU B 1 403 ? -42.241 10.460 42.156 1.00 14.06 ? 387 LEU B O 1 ATOM 5831 C CB . LEU B 1 403 ? -39.880 12.054 42.849 1.00 12.10 ? 387 LEU B CB 1 ATOM 5832 C CG . LEU B 1 403 ? -39.297 11.976 41.438 1.00 13.17 ? 387 LEU B CG 1 ATOM 5833 C CD1 . LEU B 1 403 ? -39.405 13.314 40.727 1.00 13.31 ? 387 LEU B CD1 1 ATOM 5834 C CD2 . LEU B 1 403 ? -37.848 11.515 41.503 1.00 12.40 ? 387 LEU B CD2 1 ATOM 5835 N N . LYS B 1 404 ? -43.017 12.367 41.251 1.00 9.72 ? 388 LYS B N 1 ATOM 5836 C CA . LYS B 1 404 ? -44.012 11.701 40.419 1.00 7.94 ? 388 LYS B CA 1 ATOM 5837 C C . LYS B 1 404 ? -43.591 11.695 38.952 1.00 11.78 ? 388 LYS B C 1 ATOM 5838 O O . LYS B 1 404 ? -43.612 12.729 38.284 1.00 9.92 ? 388 LYS B O 1 ATOM 5839 C CB . LYS B 1 404 ? -45.369 12.389 40.575 1.00 10.16 ? 388 LYS B CB 1 ATOM 5840 C CG . LYS B 1 404 ? -46.535 11.604 39.999 1.00 13.28 ? 388 LYS B CG 1 ATOM 5841 C CD . LYS B 1 404 ? -47.853 12.335 40.200 1.00 18.73 ? 388 LYS B CD 1 ATOM 5842 C CE . LYS B 1 404 ? -49.035 11.397 40.033 1.00 11.56 ? 388 LYS B CE 1 ATOM 5843 N NZ . LYS B 1 404 ? -50.280 12.123 39.662 1.00 12.81 ? 388 LYS B NZ 1 ATOM 5844 N N . LEU B 1 405 ? -43.208 10.520 38.462 1.00 6.59 ? 389 LEU B N 1 ATOM 5845 C CA . LEU B 1 405 ? -42.735 10.367 37.095 1.00 4.01 ? 389 LEU B CA 1 ATOM 5846 C C . LEU B 1 405 ? -43.800 9.701 36.233 1.00 7.42 ? 389 LEU B C 1 ATOM 5847 O O . LEU B 1 405 ? -44.457 8.758 36.667 1.00 8.24 ? 389 LEU B O 1 ATOM 5848 C CB . LEU B 1 405 ? -41.463 9.522 37.079 1.00 5.86 ? 389 LEU B CB 1 ATOM 5849 C CG . LEU B 1 405 ? -40.398 9.918 38.102 1.00 5.95 ? 389 LEU B CG 1 ATOM 5850 C CD1 . LEU B 1 405 ? -39.405 8.785 38.301 1.00 8.42 ? 389 LEU B CD1 1 ATOM 5851 C CD2 . LEU B 1 405 ? -39.687 11.188 37.666 1.00 6.36 ? 389 LEU B CD2 1 ATOM 5852 N N . SER B 1 406 ? -43.965 10.190 35.009 1.00 8.32 ? 390 SER B N 1 ATOM 5853 C CA . SER B 1 406 ? -44.909 9.596 34.070 1.00 6.79 ? 390 SER B CA 1 ATOM 5854 C C . SER B 1 406 ? -44.190 8.605 33.166 1.00 5.95 ? 390 SER B C 1 ATOM 5855 O O . SER B 1 406 ? -42.965 8.634 33.047 1.00 3.95 ? 390 SER B O 1 ATOM 5856 C CB . SER B 1 406 ? -45.570 10.680 33.216 1.00 5.37 ? 390 SER B CB 1 ATOM 5857 O OG . SER B 1 406 ? -44.590 11.460 32.557 1.00 7.86 ? 390 SER B OG 1 ATOM 5858 N N . TRP B 1 407 ? -44.955 7.730 32.525 1.00 8.31 ? 391 TRP B N 1 ATOM 5859 C CA . TRP B 1 407 ? -44.387 6.776 31.584 1.00 6.96 ? 391 TRP B CA 1 ATOM 5860 C C . TRP B 1 407 ? -45.454 6.223 30.650 1.00 6.03 ? 391 TRP B C 1 ATOM 5861 O O . TRP B 1 407 ? -46.589 5.988 31.062 1.00 9.07 ? 391 TRP B O 1 ATOM 5862 C CB . TRP B 1 407 ? -43.718 5.619 32.330 1.00 7.82 ? 391 TRP B CB 1 ATOM 5863 C CG . TRP B 1 407 ? -42.972 4.709 31.419 1.00 7.77 ? 391 TRP B CG 1 ATOM 5864 C CD1 . TRP B 1 407 ? -43.364 3.476 30.990 1.00 11.00 ? 391 TRP B CD1 1 ATOM 5865 C CD2 . TRP B 1 407 ? -41.705 4.965 30.806 1.00 6.01 ? 391 TRP B CD2 1 ATOM 5866 N NE1 . TRP B 1 407 ? -42.416 2.946 30.148 1.00 10.43 ? 391 TRP B NE1 1 ATOM 5867 C CE2 . TRP B 1 407 ? -41.387 3.841 30.021 1.00 5.59 ? 391 TRP B CE2 1 ATOM 5868 C CE3 . TRP B 1 407 ? -40.807 6.036 30.846 1.00 6.67 ? 391 TRP B CE3 1 ATOM 5869 C CZ2 . TRP B 1 407 ? -40.211 3.755 29.286 1.00 6.56 ? 391 TRP B CZ2 1 ATOM 5870 C CZ3 . TRP B 1 407 ? -39.639 5.948 30.114 1.00 9.76 ? 391 TRP B CZ3 1 ATOM 5871 C CH2 . TRP B 1 407 ? -39.352 4.817 29.344 1.00 7.98 ? 391 TRP B CH2 1 ATOM 5872 N N . PHE B 1 408 ? -45.084 6.018 29.389 1.00 8.33 ? 392 PHE B N 1 ATOM 5873 C CA . PHE B 1 408 ? -45.968 5.355 28.440 1.00 5.65 ? 392 PHE B CA 1 ATOM 5874 C C . PHE B 1 408 ? -45.318 4.072 27.936 1.00 8.54 ? 392 PHE B C 1 ATOM 5875 O O . PHE B 1 408 ? -44.256 4.102 27.313 1.00 8.03 ? 392 PHE B O 1 ATOM 5876 C CB . PHE B 1 408 ? -46.321 6.265 27.263 1.00 5.27 ? 392 PHE B CB 1 ATOM 5877 C CG . PHE B 1 408 ? -47.166 5.589 26.224 1.00 5.93 ? 392 PHE B CG 1 ATOM 5878 C CD1 . PHE B 1 408 ? -48.523 5.407 26.428 1.00 3.96 ? 392 PHE B CD1 1 ATOM 5879 C CD2 . PHE B 1 408 ? -46.599 5.116 25.053 1.00 5.66 ? 392 PHE B CD2 1 ATOM 5880 C CE1 . PHE B 1 408 ? -49.302 4.775 25.478 1.00 3.25 ? 392 PHE B CE1 1 ATOM 5881 C CE2 . PHE B 1 408 ? -47.372 4.484 24.100 1.00 5.91 ? 392 PHE B CE2 1 ATOM 5882 C CZ . PHE B 1 408 ? -48.725 4.313 24.313 1.00 5.08 ? 392 PHE B CZ 1 ATOM 5883 N N . LYS B 1 409 ? -45.966 2.947 28.215 1.00 7.31 ? 393 LYS B N 1 ATOM 5884 C CA . LYS B 1 409 ? -45.434 1.639 27.864 1.00 8.95 ? 393 LYS B CA 1 ATOM 5885 C C . LYS B 1 409 ? -46.235 1.022 26.722 1.00 8.21 ? 393 LYS B C 1 ATOM 5886 O O . LYS B 1 409 ? -47.410 0.693 26.880 1.00 10.23 ? 393 LYS B O 1 ATOM 5887 C CB . LYS B 1 409 ? -45.462 0.736 29.097 1.00 5.21 ? 393 LYS B CB 1 ATOM 5888 C CG . LYS B 1 409 ? -45.150 -0.722 28.845 1.00 3.11 ? 393 LYS B CG 1 ATOM 5889 C CD . LYS B 1 409 ? -44.957 -1.435 30.169 1.00 3.98 ? 393 LYS B CD 1 ATOM 5890 C CE . LYS B 1 409 ? -45.078 -2.936 30.026 1.00 2.40 ? 393 LYS B CE 1 ATOM 5891 N NZ . LYS B 1 409 ? -44.717 -3.629 31.292 1.00 3.14 ? 393 LYS B NZ 1 ATOM 5892 N N . LYS B 1 410 ? -45.595 0.871 25.567 1.00 7.66 ? 394 LYS B N 1 ATOM 5893 C CA . LYS B 1 410 ? -46.276 0.368 24.379 1.00 9.68 ? 394 LYS B CA 1 ATOM 5894 C C . LYS B 1 410 ? -46.312 -1.159 24.367 1.00 13.45 ? 394 LYS B C 1 ATOM 5895 O O . LYS B 1 410 ? -45.529 -1.815 25.055 1.00 13.67 ? 394 LYS B O 1 ATOM 5896 C CB . LYS B 1 410 ? -45.596 0.889 23.109 1.00 9.31 ? 394 LYS B CB 1 ATOM 5897 C CG . LYS B 1 410 ? -44.193 0.358 22.899 1.00 21.15 ? 394 LYS B CG 1 ATOM 5898 C CD . LYS B 1 410 ? -43.562 0.903 21.624 1.00 30.59 ? 394 LYS B CD 1 ATOM 5899 C CE . LYS B 1 410 ? -42.832 2.217 21.866 1.00 34.46 ? 394 LYS B CE 1 ATOM 5900 N NZ . LYS B 1 410 ? -41.770 2.453 20.850 1.00 42.91 ? 394 LYS B NZ 1 ATOM 5901 N N . GLY B 1 411 ? -47.224 -1.718 23.577 1.00 10.91 ? 395 GLY B N 1 ATOM 5902 C CA . GLY B 1 411 ? -47.384 -3.159 23.488 1.00 10.84 ? 395 GLY B CA 1 ATOM 5903 C C . GLY B 1 411 ? -46.120 -3.860 23.024 1.00 8.26 ? 395 GLY B C 1 ATOM 5904 O O . GLY B 1 411 ? -45.257 -3.251 22.393 1.00 10.07 ? 395 GLY B O 1 ATOM 5905 N N . SER B 1 412 ? -46.015 -5.148 23.339 1.00 7.87 ? 396 SER B N 1 ATOM 5906 C CA . SER B 1 412 ? -44.838 -5.936 22.989 1.00 10.66 ? 396 SER B CA 1 ATOM 5907 C C . SER B 1 412 ? -44.657 -6.049 21.476 1.00 9.59 ? 396 SER B C 1 ATOM 5908 O O . SER B 1 412 ? -45.627 -6.013 20.719 1.00 9.42 ? 396 SER B O 1 ATOM 5909 C CB . SER B 1 412 ? -44.941 -7.338 23.595 1.00 9.13 ? 396 SER B CB 1 ATOM 5910 O OG . SER B 1 412 ? -45.177 -7.281 24.991 1.00 5.38 ? 396 SER B OG 1 ATOM 5911 N N . SER B 1 413 ? -43.408 -6.196 21.045 1.00 10.48 ? 397 SER B N 1 ATOM 5912 C CA . SER B 1 413 ? -43.091 -6.357 19.630 1.00 9.16 ? 397 SER B CA 1 ATOM 5913 C C . SER B 1 413 ? -41.823 -7.189 19.487 1.00 8.64 ? 397 SER B C 1 ATOM 5914 O O . SER B 1 413 ? -40.910 -7.082 20.307 1.00 9.67 ? 397 SER B O 1 ATOM 5915 C CB . SER B 1 413 ? -42.906 -4.991 18.964 1.00 7.36 ? 397 SER B CB 1 ATOM 5916 O OG . SER B 1 413 ? -42.553 -5.122 17.598 1.00 7.09 ? 397 SER B OG 1 ATOM 5917 N N . ILE B 1 414 ? -41.763 -8.020 18.451 1.00 9.17 ? 398 ILE B N 1 ATOM 5918 C CA . ILE B 1 414 ? -40.601 -8.880 18.245 1.00 11.37 ? 398 ILE B CA 1 ATOM 5919 C C . ILE B 1 414 ? -39.457 -8.161 17.519 1.00 7.57 ? 398 ILE B C 1 ATOM 5920 O O . ILE B 1 414 ? -38.419 -8.762 17.245 1.00 7.52 ? 398 ILE B O 1 ATOM 5921 C CB . ILE B 1 414 ? -40.975 -10.178 17.487 1.00 9.41 ? 398 ILE B CB 1 ATOM 5922 C CG1 . ILE B 1 414 ? -41.399 -9.867 16.050 1.00 9.20 ? 398 ILE B CG1 1 ATOM 5923 C CG2 . ILE B 1 414 ? -42.080 -10.917 18.229 1.00 9.80 ? 398 ILE B CG2 1 ATOM 5924 C CD1 . ILE B 1 414 ? -41.687 -11.096 15.220 1.00 6.68 ? 398 ILE B CD1 1 ATOM 5925 N N . GLY B 1 415 ? -39.649 -6.878 17.212 1.00 12.83 ? 399 GLY B N 1 ATOM 5926 C CA . GLY B 1 415 ? -38.603 -6.067 16.606 1.00 11.55 ? 399 GLY B CA 1 ATOM 5927 C C . GLY B 1 415 ? -39.045 -5.311 15.364 1.00 10.87 ? 399 GLY B C 1 ATOM 5928 O O . GLY B 1 415 ? -40.193 -5.421 14.936 1.00 9.04 ? 399 GLY B O 1 ATOM 5929 N N . LYS B 1 416 ? -38.127 -4.534 14.792 1.00 13.55 ? 400 LYS B N 1 ATOM 5930 C CA . LYS B 1 416 ? -38.389 -3.802 13.554 1.00 14.85 ? 400 LYS B CA 1 ATOM 5931 C C . LYS B 1 416 ? -38.289 -4.726 12.348 1.00 10.47 ? 400 LYS B C 1 ATOM 5932 O O . LYS B 1 416 ? -37.512 -5.677 12.357 1.00 14.17 ? 400 LYS B O 1 ATOM 5933 C CB . LYS B 1 416 ? -37.392 -2.657 13.381 1.00 16.30 ? 400 LYS B CB 1 ATOM 5934 C CG . LYS B 1 416 ? -37.826 -1.359 14.027 1.00 17.10 ? 400 LYS B CG 1 ATOM 5935 C CD . LYS B 1 416 ? -36.815 -0.250 13.772 1.00 21.15 ? 400 LYS B CD 1 ATOM 5936 C CE . LYS B 1 416 ? -37.104 0.495 12.476 1.00 24.62 ? 400 LYS B CE 1 ATOM 5937 N NZ . LYS B 1 416 ? -36.263 1.717 12.340 1.00 20.60 ? 400 LYS B NZ 1 ATOM 5938 N N . MET B 1 417 ? -39.067 -4.442 11.308 1.00 11.05 ? 401 MET B N 1 ATOM 5939 C CA . MET B 1 417 ? -38.976 -5.202 10.067 1.00 15.70 ? 401 MET B CA 1 ATOM 5940 C C . MET B 1 417 ? -37.650 -4.917 9.378 1.00 17.02 ? 401 MET B C 1 ATOM 5941 O O . MET B 1 417 ? -37.167 -3.786 9.390 1.00 13.89 ? 401 MET B O 1 ATOM 5942 C CB . MET B 1 417 ? -40.123 -4.835 9.125 1.00 22.67 ? 401 MET B CB 1 ATOM 5943 C CG . MET B 1 417 ? -40.082 -5.557 7.782 1.00 25.70 ? 401 MET B CG 1 ATOM 5944 S SD . MET B 1 417 ? -40.530 -7.297 7.907 1.00 40.53 ? 401 MET B SD 1 ATOM 5945 C CE . MET B 1 417 ? -42.284 -7.160 8.248 1.00 25.41 ? 401 MET B CE 1 ATOM 5946 N N . PHE B 1 418 ? -37.065 -5.946 8.776 1.00 18.96 ? 402 PHE B N 1 ATOM 5947 C CA . PHE B 1 418 ? -35.840 -5.771 8.010 1.00 17.53 ? 402 PHE B CA 1 ATOM 5948 C C . PHE B 1 418 ? -36.168 -5.410 6.566 1.00 22.74 ? 402 PHE B C 1 ATOM 5949 O O . PHE B 1 418 ? -36.958 -6.091 5.910 1.00 17.43 ? 402 PHE B O 1 ATOM 5950 C CB . PHE B 1 418 ? -34.982 -7.036 8.051 1.00 17.54 ? 402 PHE B CB 1 ATOM 5951 C CG . PHE B 1 418 ? -33.824 -7.007 7.096 1.00 17.25 ? 402 PHE B CG 1 ATOM 5952 C CD1 . PHE B 1 418 ? -32.594 -6.502 7.484 1.00 15.37 ? 402 PHE B CD1 1 ATOM 5953 C CD2 . PHE B 1 418 ? -33.970 -7.476 5.802 1.00 13.92 ? 402 PHE B CD2 1 ATOM 5954 C CE1 . PHE B 1 418 ? -31.531 -6.472 6.599 1.00 14.61 ? 402 PHE B CE1 1 ATOM 5955 C CE2 . PHE B 1 418 ? -32.913 -7.448 4.915 1.00 16.76 ? 402 PHE B CE2 1 ATOM 5956 C CZ . PHE B 1 418 ? -31.692 -6.947 5.314 1.00 12.50 ? 402 PHE B CZ 1 ATOM 5957 N N . GLU B 1 419 ? -35.560 -4.333 6.080 1.00 20.29 ? 403 GLU B N 1 ATOM 5958 C CA . GLU B 1 419 ? -35.771 -3.885 4.710 1.00 20.96 ? 403 GLU B CA 1 ATOM 5959 C C . GLU B 1 419 ? -34.482 -4.016 3.907 1.00 21.10 ? 403 GLU B C 1 ATOM 5960 O O . GLU B 1 419 ? -33.510 -3.302 4.152 1.00 24.40 ? 403 GLU B O 1 ATOM 5961 C CB . GLU B 1 419 ? -36.253 -2.432 4.694 1.00 26.35 ? 403 GLU B CB 1 ATOM 5962 C CG . GLU B 1 419 ? -37.321 -2.106 5.735 1.00 22.22 ? 403 GLU B CG 1 ATOM 5963 C CD . GLU B 1 419 ? -38.616 -2.873 5.528 1.00 35.34 ? 403 GLU B CD 1 ATOM 5964 O OE1 . GLU B 1 419 ? -39.653 -2.445 6.078 1.00 34.49 ? 403 GLU B OE1 1 ATOM 5965 O OE2 . GLU B 1 419 ? -38.601 -3.902 4.822 1.00 36.87 ? 403 GLU B OE2 1 ATOM 5966 N N . ALA B 1 420 ? -34.484 -4.935 2.946 1.00 20.33 ? 404 ALA B N 1 ATOM 5967 C CA . ALA B 1 420 ? -33.314 -5.176 2.112 1.00 16.18 ? 404 ALA B CA 1 ATOM 5968 C C . ALA B 1 420 ? -33.089 -4.006 1.163 1.00 26.86 ? 404 ALA B C 1 ATOM 5969 O O . ALA B 1 420 ? -33.085 -2.847 1.578 1.00 32.80 ? 404 ALA B O 1 ATOM 5970 C CB . ALA B 1 420 ? -33.480 -6.474 1.327 1.00 13.77 ? 404 ALA B CB 1 HETATM 5971 C C1 . NAG C 2 . ? -12.716 16.650 7.563 1.00 42.50 ? 501 NAG A C1 1 HETATM 5972 C C2 . NAG C 2 . ? -12.184 17.955 6.963 1.00 36.15 ? 501 NAG A C2 1 HETATM 5973 C C3 . NAG C 2 . ? -10.818 17.683 6.346 1.00 38.62 ? 501 NAG A C3 1 HETATM 5974 C C4 . NAG C 2 . ? -10.157 16.556 7.126 1.00 43.41 ? 501 NAG A C4 1 HETATM 5975 C C5 . NAG C 2 . ? -10.931 15.257 6.909 1.00 38.77 ? 501 NAG A C5 1 HETATM 5976 C C6 . NAG C 2 . ? -10.677 14.274 8.049 1.00 38.25 ? 501 NAG A C6 1 HETATM 5977 C C7 . NAG C 2 . ? -13.918 19.515 6.263 1.00 31.90 ? 501 NAG A C7 1 HETATM 5978 C C8 . NAG C 2 . ? -14.226 20.487 5.164 1.00 21.25 ? 501 NAG A C8 1 HETATM 5979 N N2 . NAG C 2 . ? -13.079 18.525 5.967 1.00 33.59 ? 501 NAG A N2 1 HETATM 5980 O O3 . NAG C 2 . ? -9.999 18.834 6.374 1.00 39.50 ? 501 NAG A O3 1 HETATM 5981 O O4 . NAG C 2 . ? -8.823 16.384 6.696 1.00 53.75 ? 501 NAG A O4 1 HETATM 5982 O O5 . NAG C 2 . ? -12.315 15.529 6.804 1.00 46.28 ? 501 NAG A O5 1 HETATM 5983 O O6 . NAG C 2 . ? -10.863 12.953 7.593 1.00 44.13 ? 501 NAG A O6 1 HETATM 5984 O O7 . NAG C 2 . ? -14.436 19.644 7.370 1.00 36.36 ? 501 NAG A O7 1 HETATM 5985 CD CD . CD D 3 . ? -35.616 11.155 26.376 1.00 53.85 ? 502 CD A CD 1 HETATM 5986 CD CD . CD E 3 . ? -40.018 10.061 -54.476 1.00 52.12 ? 503 CD A CD 1 HETATM 5987 CL CL . CL F 4 . ? -31.303 12.703 31.332 1.00 9.47 ? 504 CL A CL 1 HETATM 5988 C C1 . NAG G 2 . ? -10.867 -18.009 -10.615 1.00 51.28 ? 501 NAG B C1 1 HETATM 5989 C C2 . NAG G 2 . ? -9.840 -19.132 -10.723 1.00 51.05 ? 501 NAG B C2 1 HETATM 5990 C C3 . NAG G 2 . ? -8.399 -18.641 -10.851 1.00 55.03 ? 501 NAG B C3 1 HETATM 5991 C C4 . NAG G 2 . ? -8.273 -17.374 -11.691 1.00 55.04 ? 501 NAG B C4 1 HETATM 5992 C C5 . NAG G 2 . ? -9.343 -16.367 -11.296 1.00 53.99 ? 501 NAG B C5 1 HETATM 5993 C C6 . NAG G 2 . ? -9.225 -15.063 -12.081 1.00 53.15 ? 501 NAG B C6 1 HETATM 5994 C C7 . NAG G 2 . ? -10.139 -19.437 -8.330 1.00 58.71 ? 501 NAG B C7 1 HETATM 5995 C C8 . NAG G 2 . ? -8.986 -19.502 -7.373 1.00 58.49 ? 501 NAG B C8 1 HETATM 5996 N N2 . NAG G 2 . ? -9.933 -19.961 -9.537 1.00 47.35 ? 501 NAG B N2 1 HETATM 5997 O O3 . NAG G 2 . ? -7.616 -19.659 -11.436 1.00 46.14 ? 501 NAG B O3 1 HETATM 5998 O O4 . NAG G 2 . ? -7.001 -16.799 -11.492 1.00 53.44 ? 501 NAG B O4 1 HETATM 5999 O O5 . NAG G 2 . ? -10.601 -16.957 -11.519 1.00 54.25 ? 501 NAG B O5 1 HETATM 6000 O O6 . NAG G 2 . ? -9.564 -15.286 -13.431 1.00 48.10 ? 501 NAG B O6 1 HETATM 6001 O O7 . NAG G 2 . ? -11.204 -18.924 -7.987 1.00 57.55 ? 501 NAG B O7 1 HETATM 6002 CD CD . CD H 3 . ? -37.296 -9.969 51.204 1.00 65.01 ? 502 CD B CD 1 HETATM 6003 CD CD . CD I 3 . ? -30.993 -4.963 36.931 1.00 62.42 ? 503 CD B CD 1 HETATM 6004 O O . HOH J 5 . ? -17.358 1.806 -60.424 1.00 11.84 ? 601 HOH A O 1 HETATM 6005 O O . HOH J 5 . ? -24.318 1.436 -58.823 1.00 22.00 ? 602 HOH A O 1 HETATM 6006 O O . HOH J 5 . ? -49.493 -4.751 -49.759 1.00 13.81 ? 603 HOH A O 1 HETATM 6007 O O . HOH J 5 . ? -25.771 20.713 -26.981 1.00 6.16 ? 604 HOH A O 1 HETATM 6008 O O . HOH J 5 . ? -39.206 20.352 -14.522 1.00 10.33 ? 605 HOH A O 1 HETATM 6009 O O . HOH J 5 . ? -33.853 22.373 -29.158 1.00 7.21 ? 606 HOH A O 1 HETATM 6010 O O . HOH J 5 . ? -30.553 17.234 13.740 1.00 8.48 ? 607 HOH A O 1 HETATM 6011 O O . HOH J 5 . ? -31.617 13.672 29.102 1.00 9.18 ? 608 HOH A O 1 HETATM 6012 O O . HOH J 5 . ? -35.377 18.746 0.010 1.00 20.99 ? 609 HOH A O 1 HETATM 6013 O O . HOH J 5 . ? -39.233 4.017 -38.585 1.00 22.51 ? 610 HOH A O 1 HETATM 6014 O O . HOH J 5 . ? -7.631 17.861 8.038 1.00 27.48 ? 611 HOH A O 1 HETATM 6015 O O . HOH J 5 . ? -42.460 4.148 -52.232 1.00 15.23 ? 612 HOH A O 1 HETATM 6016 O O . HOH J 5 . ? -21.995 7.543 -14.434 1.00 15.02 ? 613 HOH A O 1 HETATM 6017 O O . HOH J 5 . ? -26.699 24.474 -32.228 1.00 7.00 ? 614 HOH A O 1 HETATM 6018 O O . HOH J 5 . ? -6.546 15.049 5.490 1.00 18.72 ? 615 HOH A O 1 HETATM 6019 O O . HOH J 5 . ? -59.983 -1.170 -46.860 1.00 31.67 ? 616 HOH A O 1 HETATM 6020 O O . HOH J 5 . ? -38.816 3.604 -55.152 1.00 18.76 ? 617 HOH A O 1 HETATM 6021 O O . HOH J 5 . ? -23.132 19.962 -2.668 1.00 8.50 ? 618 HOH A O 1 HETATM 6022 O O . HOH J 5 . ? -23.614 -2.550 -15.745 1.00 28.92 ? 619 HOH A O 1 HETATM 6023 O O . HOH J 5 . ? -41.216 9.098 -56.563 1.00 15.95 ? 620 HOH A O 1 HETATM 6024 O O . HOH J 5 . ? -22.463 9.878 10.984 1.00 15.00 ? 621 HOH A O 1 HETATM 6025 O O . HOH J 5 . ? -33.815 2.003 -45.669 1.00 12.34 ? 622 HOH A O 1 HETATM 6026 O O . HOH J 5 . ? -26.164 26.615 -28.974 1.00 14.50 ? 623 HOH A O 1 HETATM 6027 O O . HOH J 5 . ? -33.469 21.212 9.468 1.00 3.42 ? 624 HOH A O 1 HETATM 6028 O O . HOH J 5 . ? -23.880 22.205 -20.058 1.00 5.68 ? 625 HOH A O 1 HETATM 6029 O O . HOH J 5 . ? -42.135 6.692 -55.508 1.00 23.99 ? 626 HOH A O 1 HETATM 6030 O O . HOH J 5 . ? -39.464 10.486 -13.833 1.00 7.49 ? 627 HOH A O 1 HETATM 6031 O O . HOH J 5 . ? -25.128 2.163 14.004 1.00 23.69 ? 628 HOH A O 1 HETATM 6032 O O . HOH J 5 . ? -48.656 2.542 -47.677 1.00 11.02 ? 629 HOH A O 1 HETATM 6033 O O . HOH J 5 . ? -25.507 22.118 -37.139 1.00 9.00 ? 630 HOH A O 1 HETATM 6034 O O . HOH J 5 . ? -26.539 -3.645 -59.232 1.00 28.04 ? 631 HOH A O 1 HETATM 6035 O O . HOH J 5 . ? -32.457 16.757 -26.904 1.00 4.22 ? 632 HOH A O 1 HETATM 6036 O O . HOH J 5 . ? -18.802 -3.382 -20.864 1.00 23.39 ? 633 HOH A O 1 HETATM 6037 O O . HOH J 5 . ? -33.325 16.090 -12.878 1.00 5.11 ? 634 HOH A O 1 HETATM 6038 O O . HOH J 5 . ? -31.634 21.656 -1.582 1.00 21.56 ? 635 HOH A O 1 HETATM 6039 O O . HOH J 5 . ? -40.148 8.661 -12.155 1.00 13.74 ? 636 HOH A O 1 HETATM 6040 O O . HOH J 5 . ? -38.992 7.814 -53.804 1.00 14.58 ? 637 HOH A O 1 HETATM 6041 O O . HOH J 5 . ? -25.067 2.814 11.872 1.00 24.79 ? 638 HOH A O 1 HETATM 6042 O O . HOH J 5 . ? -24.486 7.573 -77.722 1.00 26.58 ? 639 HOH A O 1 HETATM 6043 O O . HOH J 5 . ? -23.453 -0.231 -8.240 1.00 22.11 ? 640 HOH A O 1 HETATM 6044 O O . HOH J 5 . ? -40.129 18.117 -55.338 1.00 13.15 ? 641 HOH A O 1 HETATM 6045 O O . HOH J 5 . ? -17.757 14.272 -42.966 1.00 11.07 ? 642 HOH A O 1 HETATM 6046 O O . HOH J 5 . ? -20.594 11.886 -39.929 1.00 16.89 ? 643 HOH A O 1 HETATM 6047 O O . HOH J 5 . ? -36.804 5.944 -25.762 1.00 12.85 ? 644 HOH A O 1 HETATM 6048 O O . HOH J 5 . ? -40.948 7.068 -26.619 1.00 13.93 ? 645 HOH A O 1 HETATM 6049 O O . HOH J 5 . ? -35.407 20.472 35.685 1.00 23.77 ? 646 HOH A O 1 HETATM 6050 O O . HOH J 5 . ? -30.243 23.824 -2.786 1.00 19.42 ? 647 HOH A O 1 HETATM 6051 O O . HOH J 5 . ? -23.168 6.623 5.344 1.00 14.28 ? 648 HOH A O 1 HETATM 6052 O O . HOH J 5 . ? -32.993 15.446 13.005 1.00 16.93 ? 649 HOH A O 1 HETATM 6053 O O . HOH J 5 . ? -22.700 1.872 -35.444 1.00 28.71 ? 650 HOH A O 1 HETATM 6054 O O . HOH J 5 . ? -24.540 6.295 -38.561 1.00 10.62 ? 651 HOH A O 1 HETATM 6055 O O . HOH J 5 . ? -38.703 -12.413 -64.052 1.00 20.21 ? 652 HOH A O 1 HETATM 6056 O O . HOH J 5 . ? -58.129 -1.464 -50.273 1.00 46.48 ? 653 HOH A O 1 HETATM 6057 O O . HOH J 5 . ? -34.975 13.351 21.883 1.00 4.01 ? 654 HOH A O 1 HETATM 6058 O O . HOH J 5 . ? -37.339 5.505 -37.707 1.00 12.03 ? 655 HOH A O 1 HETATM 6059 O O . HOH J 5 . ? -22.847 12.449 -27.865 1.00 6.83 ? 656 HOH A O 1 HETATM 6060 O O . HOH J 5 . ? -20.666 21.166 -35.554 1.00 16.23 ? 657 HOH A O 1 HETATM 6061 O O . HOH J 5 . ? -35.585 18.135 -40.607 1.00 14.65 ? 658 HOH A O 1 HETATM 6062 O O . HOH J 5 . ? -38.949 -7.029 -63.504 1.00 24.02 ? 659 HOH A O 1 HETATM 6063 O O . HOH J 5 . ? -33.174 -14.066 -38.870 1.00 31.68 ? 660 HOH A O 1 HETATM 6064 O O . HOH J 5 . ? -17.837 13.335 1.800 1.00 12.85 ? 661 HOH A O 1 HETATM 6065 O O . HOH J 5 . ? -22.675 20.786 -45.399 1.00 11.88 ? 662 HOH A O 1 HETATM 6066 O O . HOH J 5 . ? -28.360 6.196 -48.571 1.00 13.75 ? 663 HOH A O 1 HETATM 6067 O O . HOH J 5 . ? -43.157 -16.274 -54.952 1.00 26.54 ? 664 HOH A O 1 HETATM 6068 O O . HOH J 5 . ? -37.361 21.005 -13.647 1.00 8.50 ? 665 HOH A O 1 HETATM 6069 O O . HOH J 5 . ? -26.047 -2.315 -16.869 1.00 44.60 ? 666 HOH A O 1 HETATM 6070 O O . HOH J 5 . ? -13.472 16.811 3.851 1.00 38.93 ? 667 HOH A O 1 HETATM 6071 O O . HOH J 5 . ? -33.187 21.116 38.172 1.00 41.57 ? 668 HOH A O 1 HETATM 6072 O O . HOH J 5 . ? -28.566 26.088 -68.014 1.00 19.22 ? 669 HOH A O 1 HETATM 6073 O O . HOH J 5 . ? -31.385 11.378 -39.059 1.00 26.99 ? 670 HOH A O 1 HETATM 6074 O O . HOH J 5 . ? -37.269 5.845 -57.003 1.00 26.65 ? 671 HOH A O 1 HETATM 6075 O O . HOH J 5 . ? -33.961 5.647 13.837 1.00 22.92 ? 672 HOH A O 1 HETATM 6076 O O . HOH J 5 . ? -52.556 2.269 -25.225 1.00 15.07 ? 673 HOH A O 1 HETATM 6077 O O . HOH J 5 . ? -36.683 22.298 -11.466 1.00 27.07 ? 674 HOH A O 1 HETATM 6078 O O . HOH J 5 . ? -34.851 0.365 -47.337 1.00 19.80 ? 675 HOH A O 1 HETATM 6079 O O . HOH J 5 . ? -28.276 8.646 16.108 1.00 13.84 ? 676 HOH A O 1 HETATM 6080 O O . HOH J 5 . ? -41.026 14.986 -21.800 1.00 4.50 ? 677 HOH A O 1 HETATM 6081 O O . HOH J 5 . ? -34.676 4.362 -38.029 1.00 33.11 ? 678 HOH A O 1 HETATM 6082 O O . HOH J 5 . ? -19.729 15.929 16.729 1.00 10.98 ? 679 HOH A O 1 HETATM 6083 O O . HOH J 5 . ? -21.136 5.633 21.551 1.00 39.46 ? 680 HOH A O 1 HETATM 6084 O O . HOH J 5 . ? -12.323 6.468 -54.471 1.00 41.24 ? 681 HOH A O 1 HETATM 6085 O O . HOH J 5 . ? -23.071 33.676 6.259 1.00 48.21 ? 682 HOH A O 1 HETATM 6086 O O . HOH J 5 . ? -11.844 20.257 -1.204 1.00 38.34 ? 683 HOH A O 1 HETATM 6087 O O . HOH J 5 . ? -25.145 11.536 23.590 1.00 4.84 ? 684 HOH A O 1 HETATM 6088 O O . HOH J 5 . ? -33.530 19.108 39.797 1.00 27.87 ? 685 HOH A O 1 HETATM 6089 O O . HOH J 5 . ? -34.897 16.528 39.586 1.00 16.33 ? 686 HOH A O 1 HETATM 6090 O O . HOH J 5 . ? -50.787 -1.491 -39.815 1.00 13.52 ? 687 HOH A O 1 HETATM 6091 O O . HOH J 5 . ? -21.918 19.574 -36.605 1.00 11.88 ? 688 HOH A O 1 HETATM 6092 O O . HOH J 5 . ? -22.553 18.666 20.713 1.00 16.58 ? 689 HOH A O 1 HETATM 6093 O O . HOH J 5 . ? -35.303 17.044 -34.044 1.00 15.69 ? 690 HOH A O 1 HETATM 6094 O O . HOH J 5 . ? -33.797 -0.979 -22.343 1.00 24.52 ? 691 HOH A O 1 HETATM 6095 O O . HOH J 5 . ? -26.100 0.138 -58.141 1.00 30.19 ? 692 HOH A O 1 HETATM 6096 O O . HOH J 5 . ? -39.641 14.927 -2.039 1.00 33.47 ? 693 HOH A O 1 HETATM 6097 O O . HOH J 5 . ? -45.628 -0.029 -32.027 1.00 18.29 ? 694 HOH A O 1 HETATM 6098 O O . HOH J 5 . ? -33.988 11.580 23.074 1.00 20.57 ? 695 HOH A O 1 HETATM 6099 O O . HOH J 5 . ? -35.877 17.554 -51.849 1.00 7.20 ? 696 HOH A O 1 HETATM 6100 O O . HOH J 5 . ? -46.144 3.394 -29.335 1.00 16.02 ? 697 HOH A O 1 HETATM 6101 O O . HOH J 5 . ? -28.254 4.305 -62.231 1.00 28.63 ? 698 HOH A O 1 HETATM 6102 O O . HOH J 5 . ? -35.503 14.351 -73.268 1.00 24.86 ? 699 HOH A O 1 HETATM 6103 O O . HOH J 5 . ? -31.729 8.521 -36.334 1.00 21.89 ? 700 HOH A O 1 HETATM 6104 O O . HOH J 5 . ? -32.221 20.975 -28.439 1.00 9.03 ? 701 HOH A O 1 HETATM 6105 O O . HOH J 5 . ? -46.208 -10.046 -53.920 1.00 14.44 ? 702 HOH A O 1 HETATM 6106 O O . HOH J 5 . ? -15.847 9.909 -68.638 1.00 33.86 ? 703 HOH A O 1 HETATM 6107 O O . HOH J 5 . ? -18.958 5.977 21.809 1.00 37.90 ? 704 HOH A O 1 HETATM 6108 O O . HOH J 5 . ? -24.432 -4.413 -57.944 1.00 33.18 ? 705 HOH A O 1 HETATM 6109 O O . HOH J 5 . ? -63.874 -6.875 -38.888 1.00 38.88 ? 706 HOH A O 1 HETATM 6110 O O . HOH J 5 . ? -18.727 14.680 -6.561 1.00 26.61 ? 707 HOH A O 1 HETATM 6111 O O . HOH J 5 . ? -22.916 2.468 -8.867 1.00 23.51 ? 708 HOH A O 1 HETATM 6112 O O . HOH J 5 . ? -41.386 6.243 -63.470 1.00 23.78 ? 709 HOH A O 1 HETATM 6113 O O . HOH J 5 . ? -30.799 24.621 23.611 1.00 9.76 ? 710 HOH A O 1 HETATM 6114 O O . HOH J 5 . ? -13.624 19.046 -0.564 1.00 30.59 ? 711 HOH A O 1 HETATM 6115 O O . HOH J 5 . ? -36.811 16.802 37.814 1.00 22.30 ? 712 HOH A O 1 HETATM 6116 O O . HOH J 5 . ? -41.460 11.324 -52.732 1.00 7.96 ? 713 HOH A O 1 HETATM 6117 O O . HOH J 5 . ? -36.717 -5.724 -37.835 1.00 18.29 ? 714 HOH A O 1 HETATM 6118 O O . HOH J 5 . ? -34.222 12.969 -74.609 1.00 30.23 ? 715 HOH A O 1 HETATM 6119 O O . HOH J 5 . ? -41.574 -0.371 -25.198 1.00 22.70 ? 716 HOH A O 1 HETATM 6120 O O . HOH J 5 . ? -18.333 16.722 18.814 1.00 18.68 ? 717 HOH A O 1 HETATM 6121 O O . HOH J 5 . ? -51.897 1.678 -47.704 1.00 15.41 ? 718 HOH A O 1 HETATM 6122 O O . HOH K 5 . ? -13.468 -6.690 57.776 1.00 5.89 ? 601 HOH B O 1 HETATM 6123 O O . HOH K 5 . ? -30.581 -17.173 71.333 1.00 22.10 ? 602 HOH B O 1 HETATM 6124 O O . HOH K 5 . ? -25.715 -22.400 23.841 1.00 3.10 ? 603 HOH B O 1 HETATM 6125 O O . HOH K 5 . ? -24.110 -9.405 37.762 1.00 6.42 ? 604 HOH B O 1 HETATM 6126 O O . HOH K 5 . ? -25.113 -30.279 52.169 1.00 17.22 ? 605 HOH B O 1 HETATM 6127 O O . HOH K 5 . ? -19.048 -10.293 50.729 1.00 7.23 ? 606 HOH B O 1 HETATM 6128 O O . HOH K 5 . ? -20.547 -4.962 55.516 1.00 10.86 ? 607 HOH B O 1 HETATM 6129 O O . HOH K 5 . ? -34.675 -6.652 16.849 1.00 4.38 ? 608 HOH B O 1 HETATM 6130 O O . HOH K 5 . ? -20.550 -26.563 -24.246 1.00 22.45 ? 609 HOH B O 1 HETATM 6131 O O . HOH K 5 . ? -27.302 15.919 38.993 1.00 8.91 ? 610 HOH B O 1 HETATM 6132 O O . HOH K 5 . ? -44.224 -7.655 16.713 1.00 6.92 ? 611 HOH B O 1 HETATM 6133 O O . HOH K 5 . ? -44.273 -5.386 16.082 1.00 10.01 ? 612 HOH B O 1 HETATM 6134 O O . HOH K 5 . ? -16.614 -18.472 68.775 1.00 45.54 ? 613 HOH B O 1 HETATM 6135 O O . HOH K 5 . ? -50.247 8.567 24.011 1.00 11.02 ? 614 HOH B O 1 HETATM 6136 O O . HOH K 5 . ? -27.681 -26.819 28.756 1.00 13.40 ? 615 HOH B O 1 HETATM 6137 O O . HOH K 5 . ? -53.719 -3.033 42.486 1.00 9.96 ? 616 HOH B O 1 HETATM 6138 O O . HOH K 5 . ? -14.717 -17.594 56.189 1.00 12.54 ? 617 HOH B O 1 HETATM 6139 O O . HOH K 5 . ? -39.418 -7.519 23.459 1.00 13.82 ? 618 HOH B O 1 HETATM 6140 O O . HOH K 5 . ? -25.904 -29.394 49.044 1.00 35.87 ? 619 HOH B O 1 HETATM 6141 O O . HOH K 5 . ? -34.350 -6.694 22.566 1.00 9.59 ? 620 HOH B O 1 HETATM 6142 O O . HOH K 5 . ? -41.015 -4.575 13.261 1.00 24.19 ? 621 HOH B O 1 HETATM 6143 O O . HOH K 5 . ? -32.029 -25.389 -20.027 1.00 22.21 ? 622 HOH B O 1 HETATM 6144 O O . HOH K 5 . ? -32.669 -9.632 49.947 1.00 13.62 ? 623 HOH B O 1 HETATM 6145 O O . HOH K 5 . ? -34.665 -24.408 52.158 1.00 8.32 ? 624 HOH B O 1 HETATM 6146 O O . HOH K 5 . ? -30.946 10.287 55.030 1.00 23.10 ? 625 HOH B O 1 HETATM 6147 O O . HOH K 5 . ? -25.409 -8.277 45.187 1.00 14.42 ? 626 HOH B O 1 HETATM 6148 O O . HOH K 5 . ? -34.207 -9.537 65.439 1.00 9.87 ? 627 HOH B O 1 HETATM 6149 O O . HOH K 5 . ? -24.604 -25.990 -7.600 1.00 16.90 ? 628 HOH B O 1 HETATM 6150 O O . HOH K 5 . ? -26.828 -29.146 25.442 1.00 12.09 ? 629 HOH B O 1 HETATM 6151 O O . HOH K 5 . ? -35.634 -5.221 15.508 1.00 13.86 ? 630 HOH B O 1 HETATM 6152 O O . HOH K 5 . ? -31.392 -17.961 23.889 1.00 7.21 ? 631 HOH B O 1 HETATM 6153 O O . HOH K 5 . ? -51.897 2.243 32.404 1.00 12.33 ? 632 HOH B O 1 HETATM 6154 O O . HOH K 5 . ? -12.273 -17.520 47.082 1.00 14.15 ? 633 HOH B O 1 HETATM 6155 O O . HOH K 5 . ? -25.542 -28.169 43.100 1.00 13.39 ? 634 HOH B O 1 HETATM 6156 O O . HOH K 5 . ? -24.281 -8.520 -0.595 1.00 33.53 ? 635 HOH B O 1 HETATM 6157 O O . HOH K 5 . ? -28.532 -0.291 18.146 1.00 19.15 ? 636 HOH B O 1 HETATM 6158 O O . HOH K 5 . ? -36.098 -8.072 18.238 1.00 8.34 ? 637 HOH B O 1 HETATM 6159 O O . HOH K 5 . ? -30.336 -13.060 36.488 1.00 9.55 ? 638 HOH B O 1 HETATM 6160 O O . HOH K 5 . ? -35.318 -27.821 -19.824 1.00 26.56 ? 639 HOH B O 1 HETATM 6161 O O . HOH K 5 . ? -41.549 -4.463 23.183 1.00 13.78 ? 640 HOH B O 1 HETATM 6162 O O . HOH K 5 . ? -36.209 -11.882 49.895 1.00 6.14 ? 641 HOH B O 1 HETATM 6163 O O . HOH K 5 . ? -29.394 -26.638 11.814 1.00 5.70 ? 642 HOH B O 1 HETATM 6164 O O . HOH K 5 . ? -35.669 -7.615 35.677 1.00 15.01 ? 643 HOH B O 1 HETATM 6165 O O . HOH K 5 . ? -31.971 -15.273 74.016 1.00 17.59 ? 644 HOH B O 1 HETATM 6166 O O . HOH K 5 . ? -20.027 -19.267 31.729 1.00 5.99 ? 645 HOH B O 1 HETATM 6167 O O . HOH K 5 . ? -39.834 -15.565 18.922 1.00 8.66 ? 646 HOH B O 1 HETATM 6168 O O . HOH K 5 . ? -39.253 -4.079 49.363 1.00 20.04 ? 647 HOH B O 1 HETATM 6169 O O . HOH K 5 . ? -55.162 1.422 29.215 1.00 19.79 ? 648 HOH B O 1 HETATM 6170 O O . HOH K 5 . ? -40.791 -14.509 28.119 1.00 13.49 ? 649 HOH B O 1 HETATM 6171 O O . HOH K 5 . ? -33.029 -10.668 52.463 1.00 11.20 ? 650 HOH B O 1 HETATM 6172 O O . HOH K 5 . ? -40.282 -19.004 22.822 1.00 18.68 ? 651 HOH B O 1 HETATM 6173 O O . HOH K 5 . ? -45.403 -6.304 31.710 1.00 10.02 ? 652 HOH B O 1 HETATM 6174 O O . HOH K 5 . ? -41.183 -7.027 15.805 1.00 18.97 ? 653 HOH B O 1 HETATM 6175 O O . HOH K 5 . ? -29.718 -8.740 59.650 1.00 17.18 ? 654 HOH B O 1 HETATM 6176 O O . HOH K 5 . ? -16.745 -12.954 -11.663 1.00 21.06 ? 655 HOH B O 1 HETATM 6177 O O . HOH K 5 . ? -22.867 -23.545 -30.534 1.00 26.12 ? 656 HOH B O 1 HETATM 6178 O O . HOH K 5 . ? -55.128 -1.553 43.252 1.00 10.41 ? 657 HOH B O 1 HETATM 6179 O O . HOH K 5 . ? -20.131 -4.244 5.809 1.00 18.83 ? 658 HOH B O 1 HETATM 6180 O O . HOH K 5 . ? -46.145 2.956 36.230 1.00 10.84 ? 659 HOH B O 1 HETATM 6181 O O . HOH K 5 . ? -23.464 -30.741 -13.986 1.00 35.77 ? 660 HOH B O 1 HETATM 6182 O O . HOH K 5 . ? -21.013 -11.953 -14.666 1.00 34.44 ? 661 HOH B O 1 HETATM 6183 O O . HOH K 5 . ? -25.749 7.907 36.521 1.00 15.94 ? 662 HOH B O 1 HETATM 6184 O O . HOH K 5 . ? -33.754 6.822 27.864 1.00 30.88 ? 663 HOH B O 1 HETATM 6185 O O . HOH K 5 . ? -32.053 -5.226 45.748 1.00 28.58 ? 664 HOH B O 1 HETATM 6186 O O . HOH K 5 . ? -51.964 8.370 25.684 1.00 24.26 ? 665 HOH B O 1 HETATM 6187 O O . HOH K 5 . ? -18.287 -19.648 67.847 1.00 31.38 ? 666 HOH B O 1 HETATM 6188 O O . HOH K 5 . ? -38.290 -19.221 8.759 1.00 31.44 ? 667 HOH B O 1 HETATM 6189 O O . HOH K 5 . ? -14.870 -20.876 52.092 1.00 13.79 ? 668 HOH B O 1 HETATM 6190 O O . HOH K 5 . ? -38.533 -5.081 47.581 1.00 21.86 ? 669 HOH B O 1 HETATM 6191 O O . HOH K 5 . ? -21.607 -4.360 -16.922 1.00 34.93 ? 670 HOH B O 1 HETATM 6192 O O . HOH K 5 . ? -22.027 -3.161 55.470 1.00 7.92 ? 671 HOH B O 1 HETATM 6193 O O . HOH K 5 . ? -35.608 16.119 52.192 1.00 14.21 ? 672 HOH B O 1 HETATM 6194 O O . HOH K 5 . ? -41.594 12.481 34.026 1.00 6.79 ? 673 HOH B O 1 HETATM 6195 O O . HOH K 5 . ? -38.098 -4.593 57.288 1.00 29.45 ? 674 HOH B O 1 HETATM 6196 O O . HOH K 5 . ? -16.980 -17.281 39.177 1.00 11.32 ? 675 HOH B O 1 HETATM 6197 O O . HOH K 5 . ? -34.086 -5.725 33.676 1.00 18.32 ? 676 HOH B O 1 HETATM 6198 O O . HOH K 5 . ? -18.482 -18.245 1.838 1.00 17.99 ? 677 HOH B O 1 HETATM 6199 O O . HOH K 5 . ? -35.479 13.211 55.834 1.00 25.88 ? 678 HOH B O 1 HETATM 6200 O O . HOH K 5 . ? -28.722 -6.190 47.610 1.00 16.76 ? 679 HOH B O 1 HETATM 6201 O O . HOH K 5 . ? -9.756 -17.015 -3.575 1.00 39.23 ? 680 HOH B O 1 HETATM 6202 O O . HOH K 5 . ? -41.548 -7.259 22.955 1.00 17.80 ? 681 HOH B O 1 HETATM 6203 O O . HOH K 5 . ? -28.518 -30.488 25.822 1.00 12.81 ? 682 HOH B O 1 HETATM 6204 O O . HOH K 5 . ? -40.694 -6.218 24.839 1.00 13.47 ? 683 HOH B O 1 HETATM 6205 O O . HOH K 5 . ? -22.967 -22.188 -28.282 1.00 31.52 ? 684 HOH B O 1 HETATM 6206 O O . HOH K 5 . ? -39.625 13.096 46.515 1.00 12.23 ? 685 HOH B O 1 HETATM 6207 O O . HOH K 5 . ? -29.162 -21.537 39.688 1.00 14.95 ? 686 HOH B O 1 HETATM 6208 O O . HOH K 5 . ? -41.226 -2.934 17.662 1.00 16.85 ? 687 HOH B O 1 HETATM 6209 O O . HOH K 5 . ? -26.971 -0.290 55.151 1.00 19.45 ? 688 HOH B O 1 HETATM 6210 O O . HOH K 5 . ? -18.265 -7.555 51.281 1.00 25.14 ? 689 HOH B O 1 HETATM 6211 O O . HOH K 5 . ? -35.897 -5.254 56.205 1.00 30.11 ? 690 HOH B O 1 HETATM 6212 O O . HOH K 5 . ? -27.076 -24.035 66.792 1.00 34.32 ? 691 HOH B O 1 HETATM 6213 O O . HOH K 5 . ? -57.463 0.646 33.257 1.00 24.36 ? 692 HOH B O 1 HETATM 6214 O O . HOH K 5 . ? -18.356 -26.878 60.386 1.00 14.13 ? 693 HOH B O 1 HETATM 6215 O O . HOH K 5 . ? -16.112 -3.406 48.135 1.00 29.13 ? 694 HOH B O 1 HETATM 6216 O O . HOH K 5 . ? -34.560 -8.735 38.223 1.00 16.46 ? 695 HOH B O 1 HETATM 6217 O O . HOH K 5 . ? -39.109 -5.397 20.394 1.00 20.76 ? 696 HOH B O 1 HETATM 6218 O O . HOH K 5 . ? -35.958 -21.429 7.683 1.00 30.95 ? 697 HOH B O 1 HETATM 6219 O O . HOH K 5 . ? -23.144 -22.664 33.174 1.00 12.03 ? 698 HOH B O 1 HETATM 6220 O O . HOH K 5 . ? -32.812 -4.077 40.499 1.00 31.32 ? 699 HOH B O 1 HETATM 6221 O O . HOH K 5 . ? -11.337 -18.267 -2.529 1.00 52.54 ? 700 HOH B O 1 HETATM 6222 O O . HOH K 5 . ? -24.349 -9.757 72.946 1.00 26.61 ? 701 HOH B O 1 HETATM 6223 O O . HOH K 5 . ? -38.074 10.326 32.694 1.00 11.11 ? 702 HOH B O 1 HETATM 6224 O O . HOH K 5 . ? -33.221 -6.422 -18.169 1.00 34.25 ? 703 HOH B O 1 HETATM 6225 O O . HOH K 5 . ? -38.913 -16.500 49.543 1.00 21.15 ? 704 HOH B O 1 HETATM 6226 O O . HOH K 5 . ? -36.203 -6.751 20.855 1.00 7.40 ? 705 HOH B O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 GLY 1 -15 ? ? ? A . n A 1 2 HIS 2 -14 ? ? ? A . n A 1 3 HIS 3 -13 ? ? ? A . n A 1 4 HIS 4 -12 ? ? ? A . n A 1 5 HIS 5 -11 ? ? ? A . n A 1 6 HIS 6 -10 ? ? ? A . n A 1 7 HIS 7 -9 ? ? ? A . n A 1 8 HIS 8 -8 ? ? ? A . n A 1 9 HIS 9 -7 ? ? ? A . n A 1 10 GLY 10 -6 ? ? ? A . n A 1 11 SER 11 -5 ? ? ? A . n A 1 12 SER 12 -4 ? ? ? A . n A 1 13 THR 13 -3 ? ? ? A . n A 1 14 SER 14 -2 ? ? ? A . n A 1 15 ASN 15 -1 ? ? ? A . n A 1 16 GLY 16 0 ? ? ? A . n A 1 17 MET 17 1 ? ? ? A . n A 1 18 ARG 18 2 2 ARG ARG A . n A 1 19 CYS 19 3 3 CYS CYS A . n A 1 20 VAL 20 4 4 VAL VAL A . n A 1 21 GLY 21 5 5 GLY GLY A . n A 1 22 ILE 22 6 6 ILE ILE A . n A 1 23 GLY 23 7 7 GLY GLY A . n A 1 24 ASN 24 8 8 ASN ASN A . n A 1 25 ARG 25 9 9 ARG ARG A . n A 1 26 ASP 26 10 10 ASP ASP A . n A 1 27 PHE 27 11 11 PHE PHE A . n A 1 28 VAL 28 12 12 VAL VAL A . n A 1 29 GLU 29 13 13 GLU GLU A . n A 1 30 GLY 30 14 14 GLY GLY A . n A 1 31 LEU 31 15 15 LEU LEU A . n A 1 32 SER 32 16 16 SER SER A . n A 1 33 GLY 33 17 17 GLY GLY A . n A 1 34 ALA 34 18 18 ALA ALA A . n A 1 35 THR 35 19 19 THR THR A . n A 1 36 TRP 36 20 20 TRP TRP A . n A 1 37 VAL 37 21 21 VAL VAL A . n A 1 38 ASP 38 22 22 ASP ASP A . n A 1 39 VAL 39 23 23 VAL VAL A . n A 1 40 VAL 40 24 24 VAL VAL A . n A 1 41 LEU 41 25 25 LEU LEU A . n A 1 42 GLU 42 26 26 GLU GLU A . n A 1 43 HIS 43 27 27 HIS HIS A . n A 1 44 GLY 44 28 28 GLY GLY A . n A 1 45 SER 45 29 29 SER SER A . n A 1 46 CYS 46 30 30 CYS CYS A . n A 1 47 VAL 47 31 31 VAL VAL A . n A 1 48 THR 48 32 32 THR THR A . n A 1 49 THR 49 33 33 THR THR A . n A 1 50 MET 50 34 34 MET MET A . n A 1 51 ALA 51 35 35 ALA ALA A . n A 1 52 LYS 52 36 36 LYS LYS A . n A 1 53 ASP 53 37 37 ASP ASP A . n A 1 54 LYS 54 38 38 LYS LYS A . n A 1 55 PRO 55 39 39 PRO PRO A . n A 1 56 THR 56 40 40 THR THR A . n A 1 57 LEU 57 41 41 LEU LEU A . n A 1 58 ASP 58 42 42 ASP ASP A . n A 1 59 ILE 59 43 43 ILE ILE A . n A 1 60 GLU 60 44 44 GLU GLU A . n A 1 61 LEU 61 45 45 LEU LEU A . n A 1 62 LEU 62 46 46 LEU LEU A . n A 1 63 LYS 63 47 47 LYS LYS A . n A 1 64 THR 64 48 48 THR THR A . n A 1 65 GLU 65 49 49 GLU GLU A . n A 1 66 VAL 66 50 50 VAL VAL A . n A 1 67 THR 67 51 51 THR THR A . n A 1 68 ASN 68 52 52 ASN ASN A . n A 1 69 PRO 69 53 53 PRO PRO A . n A 1 70 ALA 70 54 54 ALA ALA A . n A 1 71 VAL 71 55 55 VAL VAL A . n A 1 72 LEU 72 56 56 LEU LEU A . n A 1 73 ARG 73 57 57 ARG ARG A . n A 1 74 LYS 74 58 58 LYS LYS A . n A 1 75 LEU 75 59 59 LEU LEU A . n A 1 76 CYS 76 60 60 CYS CYS A . n A 1 77 ILE 77 61 61 ILE ILE A . n A 1 78 GLU 78 62 62 GLU GLU A . n A 1 79 ALA 79 63 63 ALA ALA A . n A 1 80 LYS 80 64 64 LYS LYS A . n A 1 81 ILE 81 65 65 ILE ILE A . n A 1 82 SER 82 66 66 SER SER A . n A 1 83 ASN 83 67 67 ASN ASN A . n A 1 84 THR 84 68 68 THR THR A . n A 1 85 THR 85 69 69 THR THR A . n A 1 86 THR 86 70 70 THR THR A . n A 1 87 ASP 87 71 71 ASP ASP A . n A 1 88 SER 88 72 72 SER SER A . n A 1 89 ARG 89 73 73 ARG ARG A . n A 1 90 CYS 90 74 74 CYS CYS A . n A 1 91 PRO 91 75 75 PRO PRO A . n A 1 92 THR 92 76 76 THR THR A . n A 1 93 GLN 93 77 77 GLN GLN A . n A 1 94 GLY 94 78 78 GLY GLY A . n A 1 95 GLU 95 79 79 GLU GLU A . n A 1 96 ALA 96 80 80 ALA ALA A . n A 1 97 THR 97 81 81 THR THR A . n A 1 98 LEU 98 82 82 LEU LEU A . n A 1 99 VAL 99 83 83 VAL VAL A . n A 1 100 GLU 100 84 84 GLU GLU A . n A 1 101 GLU 101 85 85 GLU GLU A . n A 1 102 GLN 102 86 86 GLN GLN A . n A 1 103 ASP 103 87 87 ASP ASP A . n A 1 104 THR 104 88 88 THR THR A . n A 1 105 ASN 105 89 89 ASN ASN A . n A 1 106 PHE 106 90 90 PHE PHE A . n A 1 107 VAL 107 91 91 VAL VAL A . n A 1 108 CYS 108 92 92 CYS CYS A . n A 1 109 ARG 109 93 93 ARG ARG A . n A 1 110 ARG 110 94 94 ARG ARG A . n A 1 111 THR 111 95 95 THR THR A . n A 1 112 PHE 112 96 96 PHE PHE A . n A 1 113 VAL 113 97 97 VAL VAL A . n A 1 114 ASP 114 98 98 ASP ASP A . n A 1 115 ARG 115 99 99 ARG ARG A . n A 1 116 GLY 116 100 100 GLY GLY A . n A 1 117 HIS 117 101 101 HIS HIS A . n A 1 118 GLY 118 102 102 GLY GLY A . n A 1 119 ASN 119 103 103 ASN ASN A . n A 1 120 GLY 120 104 104 GLY GLY A . n A 1 121 CYS 121 105 105 CYS CYS A . n A 1 122 GLY 122 106 106 GLY GLY A . n A 1 123 LEU 123 107 107 LEU LEU A . n A 1 124 PHE 124 108 108 PHE PHE A . n A 1 125 GLY 125 109 109 GLY GLY A . n A 1 126 LYS 126 110 110 LYS LYS A . n A 1 127 GLY 127 111 111 GLY GLY A . n A 1 128 SER 128 112 112 SER SER A . n A 1 129 LEU 129 113 113 LEU LEU A . n A 1 130 ILE 130 114 114 ILE ILE A . n A 1 131 THR 131 115 115 THR THR A . n A 1 132 CYS 132 116 116 CYS CYS A . n A 1 133 ALA 133 117 117 ALA ALA A . n A 1 134 LYS 134 118 118 LYS LYS A . n A 1 135 PHE 135 119 119 PHE PHE A . n A 1 136 LYS 136 120 120 LYS LYS A . n A 1 137 CYS 137 121 121 CYS CYS A . n A 1 138 VAL 138 122 122 VAL VAL A . n A 1 139 THR 139 123 123 THR THR A . n A 1 140 LYS 140 124 124 LYS LYS A . n A 1 141 LEU 141 125 125 LEU LEU A . n A 1 142 GLU 142 126 126 GLU GLU A . n A 1 143 GLY 143 127 127 GLY GLY A . n A 1 144 LYS 144 128 128 LYS LYS A . n A 1 145 ILE 145 129 129 ILE ILE A . n A 1 146 VAL 146 130 130 VAL VAL A . n A 1 147 GLN 147 131 131 GLN GLN A . n A 1 148 TYR 148 132 132 TYR TYR A . n A 1 149 GLU 149 133 133 GLU GLU A . n A 1 150 ASN 150 134 134 ASN ASN A . n A 1 151 LEU 151 135 135 LEU LEU A . n A 1 152 LYS 152 136 136 LYS LYS A . n A 1 153 TYR 153 137 137 TYR TYR A . n A 1 154 SER 154 138 138 SER SER A . n A 1 155 VAL 155 139 139 VAL VAL A . n A 1 156 ILE 156 140 140 ILE ILE A . n A 1 157 VAL 157 141 141 VAL VAL A . n A 1 158 THR 158 142 142 THR THR A . n A 1 159 VAL 159 143 143 VAL VAL A . n A 1 160 HIS 160 144 144 HIS HIS A . n A 1 161 THR 161 145 145 THR THR A . n A 1 162 GLY 162 146 146 GLY GLY A . n A 1 163 ASP 163 147 ? ? ? A . n A 1 164 GLN 164 148 ? ? ? A . n A 1 165 HIS 165 149 ? ? ? A . n A 1 166 GLN 166 150 ? ? ? A . n A 1 167 VAL 167 151 ? ? ? A . n A 1 168 GLY 168 152 ? ? ? A . n A 1 169 ASN 169 153 ? ? ? A . n A 1 170 GLU 170 154 ? ? ? A . n A 1 171 THR 171 155 ? ? ? A . n A 1 172 THR 172 156 ? ? ? A . n A 1 173 GLU 173 157 ? ? ? A . n A 1 174 HIS 174 158 ? ? ? A . n A 1 175 GLY 175 159 159 GLY GLY A . n A 1 176 THR 176 160 160 THR THR A . n A 1 177 ILE 177 161 161 ILE ILE A . n A 1 178 ALA 178 162 162 ALA ALA A . n A 1 179 THR 179 163 163 THR THR A . n A 1 180 ILE 180 164 164 ILE ILE A . n A 1 181 THR 181 165 165 THR THR A . n A 1 182 PRO 182 166 166 PRO PRO A . n A 1 183 GLN 183 167 167 GLN GLN A . n A 1 184 ALA 184 168 168 ALA ALA A . n A 1 185 PRO 185 169 169 PRO PRO A . n A 1 186 THR 186 170 170 THR THR A . n A 1 187 SER 187 171 171 SER SER A . n A 1 188 GLU 188 172 172 GLU GLU A . n A 1 189 ILE 189 173 173 ILE ILE A . n A 1 190 GLN 190 174 174 GLN GLN A . n A 1 191 LEU 191 175 175 LEU LEU A . n A 1 192 THR 192 176 176 THR THR A . n A 1 193 ASP 193 177 177 ASP ASP A . n A 1 194 TYR 194 178 178 TYR TYR A . n A 1 195 GLY 195 179 179 GLY GLY A . n A 1 196 ALA 196 180 180 ALA ALA A . n A 1 197 LEU 197 181 181 LEU LEU A . n A 1 198 THR 198 182 182 THR THR A . n A 1 199 LEU 199 183 183 LEU LEU A . n A 1 200 ASP 200 184 184 ASP ASP A . n A 1 201 CYS 201 185 185 CYS CYS A . n A 1 202 SER 202 186 186 SER SER A . n A 1 203 PRO 203 187 187 PRO PRO A . n A 1 204 ARG 204 188 188 ARG ARG A . n A 1 205 THR 205 189 189 THR THR A . n A 1 206 GLY 206 190 190 GLY GLY A . n A 1 207 LEU 207 191 191 LEU LEU A . n A 1 208 ASP 208 192 192 ASP ASP A . n A 1 209 PHE 209 193 193 PHE PHE A . n A 1 210 ASN 210 194 194 ASN ASN A . n A 1 211 GLU 211 195 195 GLU GLU A . n A 1 212 MET 212 196 196 MET MET A . n A 1 213 VAL 213 197 197 VAL VAL A . n A 1 214 LEU 214 198 198 LEU LEU A . n A 1 215 LEU 215 199 199 LEU LEU A . n A 1 216 THR 216 200 200 THR THR A . n A 1 217 MET 217 201 201 MET MET A . n A 1 218 LYS 218 202 202 LYS LYS A . n A 1 219 GLU 219 203 203 GLU GLU A . n A 1 220 LYS 220 204 204 LYS LYS A . n A 1 221 SER 221 205 205 SER SER A . n A 1 222 TRP 222 206 206 TRP TRP A . n A 1 223 LEU 223 207 207 LEU LEU A . n A 1 224 VAL 224 208 208 VAL VAL A . n A 1 225 HIS 225 209 209 HIS HIS A . n A 1 226 LYS 226 210 210 LYS LYS A . n A 1 227 GLN 227 211 211 GLN GLN A . n A 1 228 TRP 228 212 212 TRP TRP A . n A 1 229 PHE 229 213 213 PHE PHE A . n A 1 230 LEU 230 214 214 LEU LEU A . n A 1 231 ASP 231 215 215 ASP ASP A . n A 1 232 LEU 232 216 216 LEU LEU A . n A 1 233 PRO 233 217 217 PRO PRO A . n A 1 234 LEU 234 218 218 LEU LEU A . n A 1 235 PRO 235 219 219 PRO PRO A . n A 1 236 TRP 236 220 220 TRP TRP A . n A 1 237 THR 237 221 221 THR THR A . n A 1 238 SER 238 222 222 SER SER A . n A 1 239 GLY 239 223 223 GLY GLY A . n A 1 240 ALA 240 224 224 ALA ALA A . n A 1 241 SER 241 225 225 SER SER A . n A 1 242 THR 242 226 226 THR THR A . n A 1 243 SER 243 227 227 SER SER A . n A 1 244 GLN 244 228 228 GLN GLN A . n A 1 245 GLU 245 229 229 GLU GLU A . n A 1 246 THR 246 230 230 THR THR A . n A 1 247 TRP 247 231 231 TRP TRP A . n A 1 248 ASN 248 232 232 ASN ASN A . n A 1 249 ARG 249 233 233 ARG ARG A . n A 1 250 GLN 250 234 234 GLN GLN A . n A 1 251 ASP 251 235 235 ASP ASP A . n A 1 252 LEU 252 236 236 LEU LEU A . n A 1 253 LEU 253 237 237 LEU LEU A . n A 1 254 VAL 254 238 238 VAL VAL A . n A 1 255 THR 255 239 239 THR THR A . n A 1 256 PHE 256 240 240 PHE PHE A . n A 1 257 LYS 257 241 241 LYS LYS A . n A 1 258 THR 258 242 242 THR THR A . n A 1 259 ALA 259 243 243 ALA ALA A . n A 1 260 HIS 260 244 244 HIS HIS A . n A 1 261 ALA 261 245 245 ALA ALA A . n A 1 262 LYS 262 246 246 LYS LYS A . n A 1 263 LYS 263 247 247 LYS LYS A . n A 1 264 GLN 264 248 248 GLN GLN A . n A 1 265 GLU 265 249 249 GLU GLU A . n A 1 266 VAL 266 250 250 VAL VAL A . n A 1 267 VAL 267 251 251 VAL VAL A . n A 1 268 VAL 268 252 252 VAL VAL A . n A 1 269 LEU 269 253 253 LEU LEU A . n A 1 270 GLY 270 254 254 GLY GLY A . n A 1 271 SER 271 255 255 SER SER A . n A 1 272 GLN 272 256 256 GLN GLN A . n A 1 273 GLU 273 257 257 GLU GLU A . n A 1 274 GLY 274 258 258 GLY GLY A . n A 1 275 ALA 275 259 259 ALA ALA A . n A 1 276 MET 276 260 260 MET MET A . n A 1 277 HIS 277 261 261 HIS HIS A . n A 1 278 THR 278 262 262 THR THR A . n A 1 279 ALA 279 263 263 ALA ALA A . n A 1 280 LEU 280 264 264 LEU LEU A . n A 1 281 THR 281 265 265 THR THR A . n A 1 282 GLY 282 266 266 GLY GLY A . n A 1 283 ALA 283 267 267 ALA ALA A . n A 1 284 THR 284 268 268 THR THR A . n A 1 285 GLU 285 269 269 GLU GLU A . n A 1 286 ILE 286 270 270 ILE ILE A . n A 1 287 GLN 287 271 271 GLN GLN A . n A 1 288 THR 288 272 272 THR THR A . n A 1 289 SER 289 273 273 SER SER A . n A 1 290 GLY 290 274 274 GLY GLY A . n A 1 291 THR 291 275 275 THR THR A . n A 1 292 THR 292 276 276 THR THR A . n A 1 293 THR 293 277 277 THR THR A . n A 1 294 ILE 294 278 278 ILE ILE A . n A 1 295 PHE 295 279 279 PHE PHE A . n A 1 296 ALA 296 280 280 ALA ALA A . n A 1 297 GLY 297 281 281 GLY GLY A . n A 1 298 HIS 298 282 282 HIS HIS A . n A 1 299 LEU 299 283 283 LEU LEU A . n A 1 300 LYS 300 284 284 LYS LYS A . n A 1 301 CYS 301 285 285 CYS CYS A . n A 1 302 ARG 302 286 286 ARG ARG A . n A 1 303 LEU 303 287 287 LEU LEU A . n A 1 304 LYS 304 288 288 LYS LYS A . n A 1 305 MET 305 289 289 MET MET A . n A 1 306 ASP 306 290 290 ASP ASP A . n A 1 307 LYS 307 291 291 LYS LYS A . n A 1 308 LEU 308 292 292 LEU LEU A . n A 1 309 THR 309 293 293 THR THR A . n A 1 310 LEU 310 294 294 LEU LEU A . n A 1 311 LYS 311 295 295 LYS LYS A . n A 1 312 GLY 312 296 296 GLY GLY A . n A 1 313 MET 313 297 297 MET MET A . n A 1 314 SER 314 298 298 SER SER A . n A 1 315 TYR 315 299 299 TYR TYR A . n A 1 316 VAL 316 300 300 VAL VAL A . n A 1 317 MET 317 301 301 MET MET A . n A 1 318 CYS 318 302 302 CYS CYS A . n A 1 319 THR 319 303 303 THR THR A . n A 1 320 GLY 320 304 304 GLY GLY A . n A 1 321 SER 321 305 305 SER SER A . n A 1 322 PHE 322 306 306 PHE PHE A . n A 1 323 LYS 323 307 307 LYS LYS A . n A 1 324 LEU 324 308 308 LEU LEU A . n A 1 325 GLU 325 309 309 GLU GLU A . n A 1 326 LYS 326 310 310 LYS LYS A . n A 1 327 GLU 327 311 311 GLU GLU A . n A 1 328 VAL 328 312 312 VAL VAL A . n A 1 329 ALA 329 313 313 ALA ALA A . n A 1 330 GLU 330 314 314 GLU GLU A . n A 1 331 THR 331 315 315 THR THR A . n A 1 332 GLN 332 316 316 GLN GLN A . n A 1 333 HIS 333 317 317 HIS HIS A . n A 1 334 GLY 334 318 318 GLY GLY A . n A 1 335 THR 335 319 319 THR THR A . n A 1 336 VAL 336 320 320 VAL VAL A . n A 1 337 LEU 337 321 321 LEU LEU A . n A 1 338 VAL 338 322 322 VAL VAL A . n A 1 339 GLN 339 323 323 GLN GLN A . n A 1 340 VAL 340 324 324 VAL VAL A . n A 1 341 LYS 341 325 325 LYS LYS A . n A 1 342 TYR 342 326 326 TYR TYR A . n A 1 343 GLU 343 327 327 GLU GLU A . n A 1 344 GLY 344 328 328 GLY GLY A . n A 1 345 THR 345 329 329 THR THR A . n A 1 346 ASP 346 330 330 ASP ASP A . n A 1 347 ALA 347 331 331 ALA ALA A . n A 1 348 PRO 348 332 332 PRO PRO A . n A 1 349 CYS 349 333 333 CYS CYS A . n A 1 350 LYS 350 334 334 LYS LYS A . n A 1 351 ILE 351 335 335 ILE ILE A . n A 1 352 PRO 352 336 336 PRO PRO A . n A 1 353 PHE 353 337 337 PHE PHE A . n A 1 354 SER 354 338 338 SER SER A . n A 1 355 SER 355 339 339 SER SER A . n A 1 356 GLN 356 340 340 GLN GLN A . n A 1 357 ASP 357 341 341 ASP ASP A . n A 1 358 GLU 358 342 342 GLU GLU A . n A 1 359 LYS 359 343 343 LYS LYS A . n A 1 360 GLY 360 344 344 GLY GLY A . n A 1 361 VAL 361 345 345 VAL VAL A . n A 1 362 THR 362 346 346 THR THR A . n A 1 363 GLN 363 347 347 GLN GLN A . n A 1 364 ASN 364 348 348 ASN ASN A . n A 1 365 GLY 365 349 349 GLY GLY A . n A 1 366 ARG 366 350 350 ARG ARG A . n A 1 367 LEU 367 351 351 LEU LEU A . n A 1 368 ILE 368 352 352 ILE ILE A . n A 1 369 THR 369 353 353 THR THR A . n A 1 370 ALA 370 354 354 ALA ALA A . n A 1 371 ASN 371 355 355 ASN ASN A . n A 1 372 PRO 372 356 356 PRO PRO A . n A 1 373 ILE 373 357 357 ILE ILE A . n A 1 374 VAL 374 358 358 VAL VAL A . n A 1 375 THR 375 359 359 THR THR A . n A 1 376 ASP 376 360 360 ASP ASP A . n A 1 377 LYS 377 361 361 LYS LYS A . n A 1 378 GLU 378 362 362 GLU GLU A . n A 1 379 LYS 379 363 363 LYS LYS A . n A 1 380 PRO 380 364 364 PRO PRO A . n A 1 381 VAL 381 365 365 VAL VAL A . n A 1 382 ASN 382 366 366 ASN ASN A . n A 1 383 ILE 383 367 367 ILE ILE A . n A 1 384 GLU 384 368 368 GLU GLU A . n A 1 385 ALA 385 369 369 ALA ALA A . n A 1 386 GLU 386 370 370 GLU GLU A . n A 1 387 PRO 387 371 371 PRO PRO A . n A 1 388 PRO 388 372 372 PRO PRO A . n A 1 389 PHE 389 373 373 PHE PHE A . n A 1 390 GLY 390 374 374 GLY GLY A . n A 1 391 GLU 391 375 375 GLU GLU A . n A 1 392 SER 392 376 376 SER SER A . n A 1 393 TYR 393 377 377 TYR TYR A . n A 1 394 ILE 394 378 378 ILE ILE A . n A 1 395 VAL 395 379 379 VAL VAL A . n A 1 396 VAL 396 380 380 VAL VAL A . n A 1 397 GLY 397 381 381 GLY GLY A . n A 1 398 ALA 398 382 382 ALA ALA A . n A 1 399 GLY 399 383 383 GLY GLY A . n A 1 400 GLU 400 384 384 GLU GLU A . n A 1 401 LYS 401 385 385 LYS LYS A . n A 1 402 ALA 402 386 386 ALA ALA A . n A 1 403 LEU 403 387 387 LEU LEU A . n A 1 404 LYS 404 388 388 LYS LYS A . n A 1 405 LEU 405 389 389 LEU LEU A . n A 1 406 SER 406 390 390 SER SER A . n A 1 407 TRP 407 391 391 TRP TRP A . n A 1 408 PHE 408 392 392 PHE PHE A . n A 1 409 LYS 409 393 393 LYS LYS A . n A 1 410 LYS 410 394 394 LYS LYS A . n A 1 411 GLY 411 395 395 GLY GLY A . n A 1 412 SER 412 396 396 SER SER A . n A 1 413 SER 413 397 397 SER SER A . n A 1 414 ILE 414 398 398 ILE ILE A . n A 1 415 GLY 415 399 399 GLY GLY A . n A 1 416 LYS 416 400 400 LYS LYS A . n A 1 417 MET 417 401 401 MET MET A . n A 1 418 PHE 418 402 402 PHE PHE A . n A 1 419 GLU 419 403 403 GLU GLU A . n A 1 420 ALA 420 404 ? ? ? A . n A 1 421 THR 421 405 ? ? ? A . n A 1 422 ALA 422 406 ? ? ? A . n A 1 423 ARG 423 407 ? ? ? A . n A 1 424 GLY 424 408 ? ? ? A . n A 1 425 ALA 425 409 ? ? ? A . n A 1 426 ARG 426 410 ? ? ? A . n A 1 427 ARG 427 411 ? ? ? A . n A 1 428 MET 428 412 ? ? ? A . n A 1 429 ALA 429 413 ? ? ? A . n A 1 430 ILE 430 414 ? ? ? A . n A 1 431 LEU 431 415 ? ? ? A . n A 1 432 GLY 432 416 ? ? ? A . n A 1 433 ASP 433 417 ? ? ? A . n A 1 434 THR 434 418 ? ? ? A . n A 1 435 ALA 435 419 ? ? ? A . n A 1 436 TRP 436 420 ? ? ? A . n A 1 437 ASP 437 421 ? ? ? A . n B 1 1 GLY 1 -15 ? ? ? B . n B 1 2 HIS 2 -14 ? ? ? B . n B 1 3 HIS 3 -13 ? ? ? B . n B 1 4 HIS 4 -12 ? ? ? B . n B 1 5 HIS 5 -11 ? ? ? B . n B 1 6 HIS 6 -10 ? ? ? B . n B 1 7 HIS 7 -9 ? ? ? B . n B 1 8 HIS 8 -8 ? ? ? B . n B 1 9 HIS 9 -7 ? ? ? B . n B 1 10 GLY 10 -6 ? ? ? B . n B 1 11 SER 11 -5 ? ? ? B . n B 1 12 SER 12 -4 ? ? ? B . n B 1 13 THR 13 -3 ? ? ? B . n B 1 14 SER 14 -2 ? ? ? B . n B 1 15 ASN 15 -1 ? ? ? B . n B 1 16 GLY 16 0 ? ? ? B . n B 1 17 MET 17 1 ? ? ? B . n B 1 18 ARG 18 2 2 ARG ARG B . n B 1 19 CYS 19 3 3 CYS CYS B . n B 1 20 VAL 20 4 4 VAL VAL B . n B 1 21 GLY 21 5 5 GLY GLY B . n B 1 22 ILE 22 6 6 ILE ILE B . n B 1 23 GLY 23 7 7 GLY GLY B . n B 1 24 ASN 24 8 8 ASN ASN B . n B 1 25 ARG 25 9 9 ARG ARG B . n B 1 26 ASP 26 10 10 ASP ASP B . n B 1 27 PHE 27 11 11 PHE PHE B . n B 1 28 VAL 28 12 12 VAL VAL B . n B 1 29 GLU 29 13 13 GLU GLU B . n B 1 30 GLY 30 14 14 GLY GLY B . n B 1 31 LEU 31 15 15 LEU LEU B . n B 1 32 SER 32 16 16 SER SER B . n B 1 33 GLY 33 17 17 GLY GLY B . n B 1 34 ALA 34 18 18 ALA ALA B . n B 1 35 THR 35 19 19 THR THR B . n B 1 36 TRP 36 20 20 TRP TRP B . n B 1 37 VAL 37 21 21 VAL VAL B . n B 1 38 ASP 38 22 22 ASP ASP B . n B 1 39 VAL 39 23 23 VAL VAL B . n B 1 40 VAL 40 24 24 VAL VAL B . n B 1 41 LEU 41 25 25 LEU LEU B . n B 1 42 GLU 42 26 26 GLU GLU B . n B 1 43 HIS 43 27 27 HIS HIS B . n B 1 44 GLY 44 28 28 GLY GLY B . n B 1 45 SER 45 29 29 SER SER B . n B 1 46 CYS 46 30 30 CYS CYS B . n B 1 47 VAL 47 31 31 VAL VAL B . n B 1 48 THR 48 32 32 THR THR B . n B 1 49 THR 49 33 33 THR THR B . n B 1 50 MET 50 34 34 MET MET B . n B 1 51 ALA 51 35 35 ALA ALA B . n B 1 52 LYS 52 36 36 LYS LYS B . n B 1 53 ASP 53 37 37 ASP ASP B . n B 1 54 LYS 54 38 38 LYS LYS B . n B 1 55 PRO 55 39 39 PRO PRO B . n B 1 56 THR 56 40 40 THR THR B . n B 1 57 LEU 57 41 41 LEU LEU B . n B 1 58 ASP 58 42 42 ASP ASP B . n B 1 59 ILE 59 43 43 ILE ILE B . n B 1 60 GLU 60 44 44 GLU GLU B . n B 1 61 LEU 61 45 45 LEU LEU B . n B 1 62 LEU 62 46 46 LEU LEU B . n B 1 63 LYS 63 47 47 LYS LYS B . n B 1 64 THR 64 48 48 THR THR B . n B 1 65 GLU 65 49 49 GLU GLU B . n B 1 66 VAL 66 50 50 VAL VAL B . n B 1 67 THR 67 51 51 THR THR B . n B 1 68 ASN 68 52 52 ASN ASN B . n B 1 69 PRO 69 53 53 PRO PRO B . n B 1 70 ALA 70 54 54 ALA ALA B . n B 1 71 VAL 71 55 55 VAL VAL B . n B 1 72 LEU 72 56 56 LEU LEU B . n B 1 73 ARG 73 57 57 ARG ARG B . n B 1 74 LYS 74 58 58 LYS LYS B . n B 1 75 LEU 75 59 59 LEU LEU B . n B 1 76 CYS 76 60 60 CYS CYS B . n B 1 77 ILE 77 61 61 ILE ILE B . n B 1 78 GLU 78 62 62 GLU GLU B . n B 1 79 ALA 79 63 63 ALA ALA B . n B 1 80 LYS 80 64 64 LYS LYS B . n B 1 81 ILE 81 65 65 ILE ILE B . n B 1 82 SER 82 66 66 SER SER B . n B 1 83 ASN 83 67 67 ASN ASN B . n B 1 84 THR 84 68 68 THR THR B . n B 1 85 THR 85 69 69 THR THR B . n B 1 86 THR 86 70 70 THR THR B . n B 1 87 ASP 87 71 71 ASP ASP B . n B 1 88 SER 88 72 72 SER SER B . n B 1 89 ARG 89 73 73 ARG ARG B . n B 1 90 CYS 90 74 74 CYS CYS B . n B 1 91 PRO 91 75 75 PRO PRO B . n B 1 92 THR 92 76 76 THR THR B . n B 1 93 GLN 93 77 77 GLN GLN B . n B 1 94 GLY 94 78 78 GLY GLY B . n B 1 95 GLU 95 79 79 GLU GLU B . n B 1 96 ALA 96 80 80 ALA ALA B . n B 1 97 THR 97 81 81 THR THR B . n B 1 98 LEU 98 82 82 LEU LEU B . n B 1 99 VAL 99 83 83 VAL VAL B . n B 1 100 GLU 100 84 84 GLU ALA B . n B 1 101 GLU 101 85 85 GLU GLU B . n B 1 102 GLN 102 86 86 GLN GLN B . n B 1 103 ASP 103 87 87 ASP ASP B . n B 1 104 THR 104 88 88 THR THR B . n B 1 105 ASN 105 89 89 ASN ASN B . n B 1 106 PHE 106 90 90 PHE PHE B . n B 1 107 VAL 107 91 91 VAL VAL B . n B 1 108 CYS 108 92 92 CYS CYS B . n B 1 109 ARG 109 93 93 ARG ARG B . n B 1 110 ARG 110 94 94 ARG ARG B . n B 1 111 THR 111 95 95 THR THR B . n B 1 112 PHE 112 96 96 PHE PHE B . n B 1 113 VAL 113 97 97 VAL VAL B . n B 1 114 ASP 114 98 98 ASP ASP B . n B 1 115 ARG 115 99 99 ARG ARG B . n B 1 116 GLY 116 100 100 GLY GLY B . n B 1 117 HIS 117 101 ? ? ? B . n B 1 118 GLY 118 102 102 GLY GLY B . n B 1 119 ASN 119 103 103 ASN ASN B . n B 1 120 GLY 120 104 104 GLY GLY B . n B 1 121 CYS 121 105 105 CYS CYS B . n B 1 122 GLY 122 106 106 GLY GLY B . n B 1 123 LEU 123 107 107 LEU LEU B . n B 1 124 PHE 124 108 108 PHE PHE B . n B 1 125 GLY 125 109 109 GLY GLY B . n B 1 126 LYS 126 110 110 LYS LYS B . n B 1 127 GLY 127 111 111 GLY GLY B . n B 1 128 SER 128 112 112 SER SER B . n B 1 129 LEU 129 113 113 LEU LEU B . n B 1 130 ILE 130 114 114 ILE ILE B . n B 1 131 THR 131 115 115 THR THR B . n B 1 132 CYS 132 116 116 CYS CYS B . n B 1 133 ALA 133 117 117 ALA ALA B . n B 1 134 LYS 134 118 118 LYS LYS B . n B 1 135 PHE 135 119 119 PHE PHE B . n B 1 136 LYS 136 120 120 LYS LYS B . n B 1 137 CYS 137 121 121 CYS CYS B . n B 1 138 VAL 138 122 122 VAL VAL B . n B 1 139 THR 139 123 123 THR THR B . n B 1 140 LYS 140 124 124 LYS LYS B . n B 1 141 LEU 141 125 125 LEU LEU B . n B 1 142 GLU 142 126 126 GLU GLU B . n B 1 143 GLY 143 127 127 GLY GLY B . n B 1 144 LYS 144 128 128 LYS LYS B . n B 1 145 ILE 145 129 129 ILE ILE B . n B 1 146 VAL 146 130 130 VAL VAL B . n B 1 147 GLN 147 131 131 GLN GLN B . n B 1 148 TYR 148 132 132 TYR TYR B . n B 1 149 GLU 149 133 133 GLU GLU B . n B 1 150 ASN 150 134 134 ASN ASN B . n B 1 151 LEU 151 135 135 LEU LEU B . n B 1 152 LYS 152 136 136 LYS LYS B . n B 1 153 TYR 153 137 137 TYR TYR B . n B 1 154 SER 154 138 138 SER SER B . n B 1 155 VAL 155 139 139 VAL VAL B . n B 1 156 ILE 156 140 140 ILE ILE B . n B 1 157 VAL 157 141 141 VAL VAL B . n B 1 158 THR 158 142 142 THR THR B . n B 1 159 VAL 159 143 143 VAL VAL B . n B 1 160 HIS 160 144 144 HIS HIS B . n B 1 161 THR 161 145 145 THR THR B . n B 1 162 GLY 162 146 ? ? ? B . n B 1 163 ASP 163 147 ? ? ? B . n B 1 164 GLN 164 148 ? ? ? B . n B 1 165 HIS 165 149 ? ? ? B . n B 1 166 GLN 166 150 ? ? ? B . n B 1 167 VAL 167 151 ? ? ? B . n B 1 168 GLY 168 152 ? ? ? B . n B 1 169 ASN 169 153 ? ? ? B . n B 1 170 GLU 170 154 ? ? ? B . n B 1 171 THR 171 155 ? ? ? B . n B 1 172 THR 172 156 ? ? ? B . n B 1 173 GLU 173 157 ? ? ? B . n B 1 174 HIS 174 158 158 HIS HIS B . n B 1 175 GLY 175 159 159 GLY GLY B . n B 1 176 THR 176 160 160 THR THR B . n B 1 177 ILE 177 161 161 ILE ILE B . n B 1 178 ALA 178 162 162 ALA ALA B . n B 1 179 THR 179 163 163 THR THR B . n B 1 180 ILE 180 164 164 ILE ILE B . n B 1 181 THR 181 165 165 THR THR B . n B 1 182 PRO 182 166 166 PRO PRO B . n B 1 183 GLN 183 167 167 GLN GLN B . n B 1 184 ALA 184 168 168 ALA ALA B . n B 1 185 PRO 185 169 169 PRO PRO B . n B 1 186 THR 186 170 170 THR THR B . n B 1 187 SER 187 171 171 SER SER B . n B 1 188 GLU 188 172 172 GLU GLU B . n B 1 189 ILE 189 173 173 ILE ILE B . n B 1 190 GLN 190 174 174 GLN GLN B . n B 1 191 LEU 191 175 175 LEU LEU B . n B 1 192 THR 192 176 176 THR THR B . n B 1 193 ASP 193 177 177 ASP ASP B . n B 1 194 TYR 194 178 178 TYR TYR B . n B 1 195 GLY 195 179 179 GLY GLY B . n B 1 196 ALA 196 180 180 ALA ALA B . n B 1 197 LEU 197 181 181 LEU LEU B . n B 1 198 THR 198 182 182 THR THR B . n B 1 199 LEU 199 183 183 LEU LEU B . n B 1 200 ASP 200 184 184 ASP ASP B . n B 1 201 CYS 201 185 185 CYS CYS B . n B 1 202 SER 202 186 186 SER SER B . n B 1 203 PRO 203 187 187 PRO PRO B . n B 1 204 ARG 204 188 188 ARG ARG B . n B 1 205 THR 205 189 189 THR THR B . n B 1 206 GLY 206 190 190 GLY GLY B . n B 1 207 LEU 207 191 191 LEU LEU B . n B 1 208 ASP 208 192 192 ASP ASP B . n B 1 209 PHE 209 193 193 PHE PHE B . n B 1 210 ASN 210 194 194 ASN ASN B . n B 1 211 GLU 211 195 195 GLU GLU B . n B 1 212 MET 212 196 196 MET MET B . n B 1 213 VAL 213 197 197 VAL VAL B . n B 1 214 LEU 214 198 198 LEU LEU B . n B 1 215 LEU 215 199 199 LEU LEU B . n B 1 216 THR 216 200 200 THR THR B . n B 1 217 MET 217 201 201 MET MET B . n B 1 218 LYS 218 202 202 LYS LYS B . n B 1 219 GLU 219 203 203 GLU GLU B . n B 1 220 LYS 220 204 204 LYS LYS B . n B 1 221 SER 221 205 205 SER SER B . n B 1 222 TRP 222 206 206 TRP TRP B . n B 1 223 LEU 223 207 207 LEU LEU B . n B 1 224 VAL 224 208 208 VAL VAL B . n B 1 225 HIS 225 209 209 HIS HIS B . n B 1 226 LYS 226 210 210 LYS LYS B . n B 1 227 GLN 227 211 211 GLN GLN B . n B 1 228 TRP 228 212 212 TRP TRP B . n B 1 229 PHE 229 213 213 PHE PHE B . n B 1 230 LEU 230 214 214 LEU LEU B . n B 1 231 ASP 231 215 215 ASP ASP B . n B 1 232 LEU 232 216 216 LEU LEU B . n B 1 233 PRO 233 217 217 PRO PRO B . n B 1 234 LEU 234 218 218 LEU LEU B . n B 1 235 PRO 235 219 219 PRO PRO B . n B 1 236 TRP 236 220 220 TRP TRP B . n B 1 237 THR 237 221 221 THR THR B . n B 1 238 SER 238 222 222 SER SER B . n B 1 239 GLY 239 223 223 GLY GLY B . n B 1 240 ALA 240 224 224 ALA ALA B . n B 1 241 SER 241 225 225 SER SER B . n B 1 242 THR 242 226 226 THR THR B . n B 1 243 SER 243 227 227 SER SER B . n B 1 244 GLN 244 228 228 GLN GLN B . n B 1 245 GLU 245 229 229 GLU GLU B . n B 1 246 THR 246 230 230 THR THR B . n B 1 247 TRP 247 231 231 TRP TRP B . n B 1 248 ASN 248 232 232 ASN ASN B . n B 1 249 ARG 249 233 233 ARG ARG B . n B 1 250 GLN 250 234 234 GLN GLN B . n B 1 251 ASP 251 235 235 ASP ASP B . n B 1 252 LEU 252 236 236 LEU LEU B . n B 1 253 LEU 253 237 237 LEU LEU B . n B 1 254 VAL 254 238 238 VAL VAL B . n B 1 255 THR 255 239 239 THR THR B . n B 1 256 PHE 256 240 240 PHE PHE B . n B 1 257 LYS 257 241 241 LYS LYS B . n B 1 258 THR 258 242 242 THR THR B . n B 1 259 ALA 259 243 243 ALA ALA B . n B 1 260 HIS 260 244 244 HIS ALA B . n B 1 261 ALA 261 245 245 ALA ALA B . n B 1 262 LYS 262 246 246 LYS ALA B . n B 1 263 LYS 263 247 247 LYS ALA B . n B 1 264 GLN 264 248 248 GLN GLN B . n B 1 265 GLU 265 249 249 GLU GLU B . n B 1 266 VAL 266 250 250 VAL VAL B . n B 1 267 VAL 267 251 251 VAL VAL B . n B 1 268 VAL 268 252 252 VAL VAL B . n B 1 269 LEU 269 253 253 LEU LEU B . n B 1 270 GLY 270 254 254 GLY GLY B . n B 1 271 SER 271 255 255 SER SER B . n B 1 272 GLN 272 256 256 GLN GLN B . n B 1 273 GLU 273 257 257 GLU GLU B . n B 1 274 GLY 274 258 258 GLY GLY B . n B 1 275 ALA 275 259 259 ALA ALA B . n B 1 276 MET 276 260 260 MET MET B . n B 1 277 HIS 277 261 261 HIS HIS B . n B 1 278 THR 278 262 262 THR THR B . n B 1 279 ALA 279 263 263 ALA ALA B . n B 1 280 LEU 280 264 264 LEU LEU B . n B 1 281 THR 281 265 265 THR THR B . n B 1 282 GLY 282 266 266 GLY GLY B . n B 1 283 ALA 283 267 267 ALA ALA B . n B 1 284 THR 284 268 268 THR THR B . n B 1 285 GLU 285 269 269 GLU GLU B . n B 1 286 ILE 286 270 270 ILE ILE B . n B 1 287 GLN 287 271 271 GLN GLN B . n B 1 288 THR 288 272 272 THR THR B . n B 1 289 SER 289 273 273 SER SER B . n B 1 290 GLY 290 274 274 GLY GLY B . n B 1 291 THR 291 275 275 THR THR B . n B 1 292 THR 292 276 276 THR THR B . n B 1 293 THR 293 277 277 THR THR B . n B 1 294 ILE 294 278 278 ILE ILE B . n B 1 295 PHE 295 279 279 PHE PHE B . n B 1 296 ALA 296 280 280 ALA ALA B . n B 1 297 GLY 297 281 281 GLY GLY B . n B 1 298 HIS 298 282 282 HIS HIS B . n B 1 299 LEU 299 283 283 LEU LEU B . n B 1 300 LYS 300 284 284 LYS LYS B . n B 1 301 CYS 301 285 285 CYS CYS B . n B 1 302 ARG 302 286 286 ARG ARG B . n B 1 303 LEU 303 287 287 LEU LEU B . n B 1 304 LYS 304 288 288 LYS LYS B . n B 1 305 MET 305 289 289 MET MET B . n B 1 306 ASP 306 290 290 ASP ASP B . n B 1 307 LYS 307 291 291 LYS LYS B . n B 1 308 LEU 308 292 292 LEU LEU B . n B 1 309 THR 309 293 293 THR THR B . n B 1 310 LEU 310 294 294 LEU LEU B . n B 1 311 LYS 311 295 295 LYS LYS B . n B 1 312 GLY 312 296 296 GLY GLY B . n B 1 313 MET 313 297 297 MET MET B . n B 1 314 SER 314 298 298 SER SER B . n B 1 315 TYR 315 299 299 TYR TYR B . n B 1 316 VAL 316 300 300 VAL VAL B . n B 1 317 MET 317 301 301 MET MET B . n B 1 318 CYS 318 302 302 CYS CYS B . n B 1 319 THR 319 303 303 THR THR B . n B 1 320 GLY 320 304 304 GLY GLY B . n B 1 321 SER 321 305 305 SER SER B . n B 1 322 PHE 322 306 306 PHE PHE B . n B 1 323 LYS 323 307 307 LYS LYS B . n B 1 324 LEU 324 308 308 LEU LEU B . n B 1 325 GLU 325 309 309 GLU GLU B . n B 1 326 LYS 326 310 310 LYS LYS B . n B 1 327 GLU 327 311 311 GLU GLU B . n B 1 328 VAL 328 312 312 VAL VAL B . n B 1 329 ALA 329 313 313 ALA ALA B . n B 1 330 GLU 330 314 314 GLU GLU B . n B 1 331 THR 331 315 315 THR THR B . n B 1 332 GLN 332 316 316 GLN GLN B . n B 1 333 HIS 333 317 317 HIS HIS B . n B 1 334 GLY 334 318 318 GLY GLY B . n B 1 335 THR 335 319 319 THR THR B . n B 1 336 VAL 336 320 320 VAL VAL B . n B 1 337 LEU 337 321 321 LEU LEU B . n B 1 338 VAL 338 322 322 VAL VAL B . n B 1 339 GLN 339 323 323 GLN GLN B . n B 1 340 VAL 340 324 324 VAL VAL B . n B 1 341 LYS 341 325 325 LYS LYS B . n B 1 342 TYR 342 326 326 TYR TYR B . n B 1 343 GLU 343 327 327 GLU GLU B . n B 1 344 GLY 344 328 328 GLY GLY B . n B 1 345 THR 345 329 329 THR THR B . n B 1 346 ASP 346 330 330 ASP ASP B . n B 1 347 ALA 347 331 331 ALA ALA B . n B 1 348 PRO 348 332 332 PRO PRO B . n B 1 349 CYS 349 333 333 CYS CYS B . n B 1 350 LYS 350 334 334 LYS LYS B . n B 1 351 ILE 351 335 335 ILE ILE B . n B 1 352 PRO 352 336 336 PRO PRO B . n B 1 353 PHE 353 337 337 PHE PHE B . n B 1 354 SER 354 338 338 SER SER B . n B 1 355 SER 355 339 339 SER SER B . n B 1 356 GLN 356 340 340 GLN GLN B . n B 1 357 ASP 357 341 341 ASP ASP B . n B 1 358 GLU 358 342 342 GLU GLU B . n B 1 359 LYS 359 343 343 LYS ALA B . n B 1 360 GLY 360 344 344 GLY GLY B . n B 1 361 VAL 361 345 345 VAL VAL B . n B 1 362 THR 362 346 346 THR THR B . n B 1 363 GLN 363 347 347 GLN GLN B . n B 1 364 ASN 364 348 348 ASN ASN B . n B 1 365 GLY 365 349 349 GLY GLY B . n B 1 366 ARG 366 350 350 ARG ARG B . n B 1 367 LEU 367 351 351 LEU LEU B . n B 1 368 ILE 368 352 352 ILE ILE B . n B 1 369 THR 369 353 353 THR THR B . n B 1 370 ALA 370 354 354 ALA ALA B . n B 1 371 ASN 371 355 355 ASN ASN B . n B 1 372 PRO 372 356 356 PRO PRO B . n B 1 373 ILE 373 357 357 ILE ILE B . n B 1 374 VAL 374 358 358 VAL VAL B . n B 1 375 THR 375 359 359 THR THR B . n B 1 376 ASP 376 360 360 ASP ASP B . n B 1 377 LYS 377 361 361 LYS LYS B . n B 1 378 GLU 378 362 362 GLU ALA B . n B 1 379 LYS 379 363 363 LYS LYS B . n B 1 380 PRO 380 364 364 PRO PRO B . n B 1 381 VAL 381 365 365 VAL VAL B . n B 1 382 ASN 382 366 366 ASN ASN B . n B 1 383 ILE 383 367 367 ILE ILE B . n B 1 384 GLU 384 368 368 GLU GLU B . n B 1 385 ALA 385 369 369 ALA ALA B . n B 1 386 GLU 386 370 370 GLU GLU B . n B 1 387 PRO 387 371 371 PRO PRO B . n B 1 388 PRO 388 372 372 PRO PRO B . n B 1 389 PHE 389 373 373 PHE PHE B . n B 1 390 GLY 390 374 374 GLY GLY B . n B 1 391 GLU 391 375 375 GLU GLU B . n B 1 392 SER 392 376 376 SER SER B . n B 1 393 TYR 393 377 377 TYR TYR B . n B 1 394 ILE 394 378 378 ILE ILE B . n B 1 395 VAL 395 379 379 VAL VAL B . n B 1 396 VAL 396 380 380 VAL VAL B . n B 1 397 GLY 397 381 381 GLY GLY B . n B 1 398 ALA 398 382 382 ALA ALA B . n B 1 399 GLY 399 383 383 GLY GLY B . n B 1 400 GLU 400 384 384 GLU GLU B . n B 1 401 LYS 401 385 385 LYS ALA B . n B 1 402 ALA 402 386 386 ALA ALA B . n B 1 403 LEU 403 387 387 LEU LEU B . n B 1 404 LYS 404 388 388 LYS LYS B . n B 1 405 LEU 405 389 389 LEU LEU B . n B 1 406 SER 406 390 390 SER SER B . n B 1 407 TRP 407 391 391 TRP TRP B . n B 1 408 PHE 408 392 392 PHE PHE B . n B 1 409 LYS 409 393 393 LYS LYS B . n B 1 410 LYS 410 394 394 LYS LYS B . n B 1 411 GLY 411 395 395 GLY GLY B . n B 1 412 SER 412 396 396 SER SER B . n B 1 413 SER 413 397 397 SER SER B . n B 1 414 ILE 414 398 398 ILE ILE B . n B 1 415 GLY 415 399 399 GLY GLY B . n B 1 416 LYS 416 400 400 LYS LYS B . n B 1 417 MET 417 401 401 MET MET B . n B 1 418 PHE 418 402 402 PHE PHE B . n B 1 419 GLU 419 403 403 GLU GLU B . n B 1 420 ALA 420 404 404 ALA ALA B . n B 1 421 THR 421 405 ? ? ? B . n B 1 422 ALA 422 406 ? ? ? B . n B 1 423 ARG 423 407 ? ? ? B . n B 1 424 GLY 424 408 ? ? ? B . n B 1 425 ALA 425 409 ? ? ? B . n B 1 426 ARG 426 410 ? ? ? B . n B 1 427 ARG 427 411 ? ? ? B . n B 1 428 MET 428 412 ? ? ? B . n B 1 429 ALA 429 413 ? ? ? B . n B 1 430 ILE 430 414 ? ? ? B . n B 1 431 LEU 431 415 ? ? ? B . n B 1 432 GLY 432 416 ? ? ? B . n B 1 433 ASP 433 417 ? ? ? B . n B 1 434 THR 434 418 ? ? ? B . n B 1 435 ALA 435 419 ? ? ? B . n B 1 436 TRP 436 420 ? ? ? B . n B 1 437 ASP 437 421 ? ? ? B . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code C 2 NAG 1 501 431 NAG NAG A . D 3 CD 1 502 2 CD CD A . E 3 CD 1 503 3 CD CD A . F 4 CL 1 504 1 CL CL A . G 2 NAG 1 501 431 NAG NAG B . H 3 CD 1 502 1 CD CD B . I 3 CD 1 503 4 CD CD B . J 5 HOH 1 601 2 HOH HOH A . J 5 HOH 2 602 5 HOH HOH A . J 5 HOH 3 603 8 HOH HOH A . J 5 HOH 4 604 11 HOH HOH A . J 5 HOH 5 605 12 HOH HOH A . J 5 HOH 6 606 15 HOH HOH A . J 5 HOH 7 607 16 HOH HOH A . J 5 HOH 8 608 17 HOH HOH A . J 5 HOH 9 609 21 HOH HOH A . J 5 HOH 10 610 23 HOH HOH A . J 5 HOH 11 611 24 HOH HOH A . J 5 HOH 12 612 25 HOH HOH A . J 5 HOH 13 613 27 HOH HOH A . J 5 HOH 14 614 28 HOH HOH A . J 5 HOH 15 615 30 HOH HOH A . J 5 HOH 16 616 33 HOH HOH A . J 5 HOH 17 617 34 HOH HOH A . J 5 HOH 18 618 37 HOH HOH A . J 5 HOH 19 619 38 HOH HOH A . J 5 HOH 20 620 40 HOH HOH A . J 5 HOH 21 621 42 HOH HOH A . J 5 HOH 22 622 44 HOH HOH A . J 5 HOH 23 623 45 HOH HOH A . J 5 HOH 24 624 48 HOH HOH A . J 5 HOH 25 625 49 HOH HOH A . J 5 HOH 26 626 51 HOH HOH A . J 5 HOH 27 627 53 HOH HOH A . J 5 HOH 28 628 55 HOH HOH A . J 5 HOH 29 629 56 HOH HOH A . J 5 HOH 30 630 59 HOH HOH A . J 5 HOH 31 631 60 HOH HOH A . J 5 HOH 32 632 61 HOH HOH A . J 5 HOH 33 633 69 HOH HOH A . J 5 HOH 34 634 70 HOH HOH A . J 5 HOH 35 635 71 HOH HOH A . J 5 HOH 36 636 73 HOH HOH A . J 5 HOH 37 637 77 HOH HOH A . J 5 HOH 38 638 80 HOH HOH A . J 5 HOH 39 639 81 HOH HOH A . J 5 HOH 40 640 82 HOH HOH A . J 5 HOH 41 641 83 HOH HOH A . J 5 HOH 42 642 85 HOH HOH A . J 5 HOH 43 643 87 HOH HOH A . J 5 HOH 44 644 90 HOH HOH A . J 5 HOH 45 645 92 HOH HOH A . J 5 HOH 46 646 94 HOH HOH A . J 5 HOH 47 647 100 HOH HOH A . J 5 HOH 48 648 101 HOH HOH A . J 5 HOH 49 649 102 HOH HOH A . J 5 HOH 50 650 104 HOH HOH A . J 5 HOH 51 651 105 HOH HOH A . J 5 HOH 52 652 106 HOH HOH A . J 5 HOH 53 653 107 HOH HOH A . J 5 HOH 54 654 108 HOH HOH A . J 5 HOH 55 655 109 HOH HOH A . J 5 HOH 56 656 110 HOH HOH A . J 5 HOH 57 657 111 HOH HOH A . J 5 HOH 58 658 112 HOH HOH A . J 5 HOH 59 659 117 HOH HOH A . J 5 HOH 60 660 119 HOH HOH A . J 5 HOH 61 661 123 HOH HOH A . J 5 HOH 62 662 124 HOH HOH A . J 5 HOH 63 663 125 HOH HOH A . J 5 HOH 64 664 126 HOH HOH A . J 5 HOH 65 665 127 HOH HOH A . J 5 HOH 66 666 128 HOH HOH A . J 5 HOH 67 667 129 HOH HOH A . J 5 HOH 68 668 130 HOH HOH A . J 5 HOH 69 669 132 HOH HOH A . J 5 HOH 70 670 134 HOH HOH A . J 5 HOH 71 671 135 HOH HOH A . J 5 HOH 72 672 138 HOH HOH A . J 5 HOH 73 673 140 HOH HOH A . J 5 HOH 74 674 141 HOH HOH A . J 5 HOH 75 675 142 HOH HOH A . J 5 HOH 76 676 143 HOH HOH A . J 5 HOH 77 677 144 HOH HOH A . J 5 HOH 78 678 145 HOH HOH A . J 5 HOH 79 679 147 HOH HOH A . J 5 HOH 80 680 148 HOH HOH A . J 5 HOH 81 681 150 HOH HOH A . J 5 HOH 82 682 152 HOH HOH A . J 5 HOH 83 683 155 HOH HOH A . J 5 HOH 84 684 156 HOH HOH A . J 5 HOH 85 685 160 HOH HOH A . J 5 HOH 86 686 162 HOH HOH A . J 5 HOH 87 687 163 HOH HOH A . J 5 HOH 88 688 164 HOH HOH A . J 5 HOH 89 689 167 HOH HOH A . J 5 HOH 90 690 171 HOH HOH A . J 5 HOH 91 691 172 HOH HOH A . J 5 HOH 92 692 173 HOH HOH A . J 5 HOH 93 693 177 HOH HOH A . J 5 HOH 94 694 179 HOH HOH A . J 5 HOH 95 695 182 HOH HOH A . J 5 HOH 96 696 186 HOH HOH A . J 5 HOH 97 697 187 HOH HOH A . J 5 HOH 98 698 189 HOH HOH A . J 5 HOH 99 699 190 HOH HOH A . J 5 HOH 100 700 191 HOH HOH A . J 5 HOH 101 701 193 HOH HOH A . J 5 HOH 102 702 194 HOH HOH A . J 5 HOH 103 703 195 HOH HOH A . J 5 HOH 104 704 198 HOH HOH A . J 5 HOH 105 705 199 HOH HOH A . J 5 HOH 106 706 200 HOH HOH A . J 5 HOH 107 707 201 HOH HOH A . J 5 HOH 108 708 202 HOH HOH A . J 5 HOH 109 709 203 HOH HOH A . J 5 HOH 110 710 207 HOH HOH A . J 5 HOH 111 711 208 HOH HOH A . J 5 HOH 112 712 209 HOH HOH A . J 5 HOH 113 713 210 HOH HOH A . J 5 HOH 114 714 212 HOH HOH A . J 5 HOH 115 715 213 HOH HOH A . J 5 HOH 116 716 214 HOH HOH A . J 5 HOH 117 717 216 HOH HOH A . J 5 HOH 118 718 223 HOH HOH A . K 5 HOH 1 601 1 HOH HOH B . K 5 HOH 2 602 3 HOH HOH B . K 5 HOH 3 603 4 HOH HOH B . K 5 HOH 4 604 6 HOH HOH B . K 5 HOH 5 605 7 HOH HOH B . K 5 HOH 6 606 9 HOH HOH B . K 5 HOH 7 607 10 HOH HOH B . K 5 HOH 8 608 13 HOH HOH B . K 5 HOH 9 609 14 HOH HOH B . K 5 HOH 10 610 18 HOH HOH B . K 5 HOH 11 611 19 HOH HOH B . K 5 HOH 12 612 20 HOH HOH B . K 5 HOH 13 613 22 HOH HOH B . K 5 HOH 14 614 26 HOH HOH B . K 5 HOH 15 615 29 HOH HOH B . K 5 HOH 16 616 31 HOH HOH B . K 5 HOH 17 617 32 HOH HOH B . K 5 HOH 18 618 35 HOH HOH B . K 5 HOH 19 619 36 HOH HOH B . K 5 HOH 20 620 39 HOH HOH B . K 5 HOH 21 621 41 HOH HOH B . K 5 HOH 22 622 43 HOH HOH B . K 5 HOH 23 623 46 HOH HOH B . K 5 HOH 24 624 47 HOH HOH B . K 5 HOH 25 625 50 HOH HOH B . K 5 HOH 26 626 52 HOH HOH B . K 5 HOH 27 627 54 HOH HOH B . K 5 HOH 28 628 57 HOH HOH B . K 5 HOH 29 629 58 HOH HOH B . K 5 HOH 30 630 62 HOH HOH B . K 5 HOH 31 631 63 HOH HOH B . K 5 HOH 32 632 64 HOH HOH B . K 5 HOH 33 633 65 HOH HOH B . K 5 HOH 34 634 66 HOH HOH B . K 5 HOH 35 635 67 HOH HOH B . K 5 HOH 36 636 68 HOH HOH B . K 5 HOH 37 637 72 HOH HOH B . K 5 HOH 38 638 74 HOH HOH B . K 5 HOH 39 639 75 HOH HOH B . K 5 HOH 40 640 76 HOH HOH B . K 5 HOH 41 641 78 HOH HOH B . K 5 HOH 42 642 79 HOH HOH B . K 5 HOH 43 643 84 HOH HOH B . K 5 HOH 44 644 86 HOH HOH B . K 5 HOH 45 645 88 HOH HOH B . K 5 HOH 46 646 89 HOH HOH B . K 5 HOH 47 647 91 HOH HOH B . K 5 HOH 48 648 93 HOH HOH B . K 5 HOH 49 649 95 HOH HOH B . K 5 HOH 50 650 96 HOH HOH B . K 5 HOH 51 651 97 HOH HOH B . K 5 HOH 52 652 98 HOH HOH B . K 5 HOH 53 653 99 HOH HOH B . K 5 HOH 54 654 103 HOH HOH B . K 5 HOH 55 655 113 HOH HOH B . K 5 HOH 56 656 114 HOH HOH B . K 5 HOH 57 657 115 HOH HOH B . K 5 HOH 58 658 116 HOH HOH B . K 5 HOH 59 659 118 HOH HOH B . K 5 HOH 60 660 120 HOH HOH B . K 5 HOH 61 661 121 HOH HOH B . K 5 HOH 62 662 122 HOH HOH B . K 5 HOH 63 663 131 HOH HOH B . K 5 HOH 64 664 133 HOH HOH B . K 5 HOH 65 665 136 HOH HOH B . K 5 HOH 66 666 137 HOH HOH B . K 5 HOH 67 667 139 HOH HOH B . K 5 HOH 68 668 146 HOH HOH B . K 5 HOH 69 669 149 HOH HOH B . K 5 HOH 70 670 151 HOH HOH B . K 5 HOH 71 671 153 HOH HOH B . K 5 HOH 72 672 154 HOH HOH B . K 5 HOH 73 673 157 HOH HOH B . K 5 HOH 74 674 158 HOH HOH B . K 5 HOH 75 675 159 HOH HOH B . K 5 HOH 76 676 161 HOH HOH B . K 5 HOH 77 677 165 HOH HOH B . K 5 HOH 78 678 166 HOH HOH B . K 5 HOH 79 679 168 HOH HOH B . K 5 HOH 80 680 169 HOH HOH B . K 5 HOH 81 681 170 HOH HOH B . K 5 HOH 82 682 174 HOH HOH B . K 5 HOH 83 683 175 HOH HOH B . K 5 HOH 84 684 176 HOH HOH B . K 5 HOH 85 685 178 HOH HOH B . K 5 HOH 86 686 180 HOH HOH B . K 5 HOH 87 687 181 HOH HOH B . K 5 HOH 88 688 183 HOH HOH B . K 5 HOH 89 689 184 HOH HOH B . K 5 HOH 90 690 185 HOH HOH B . K 5 HOH 91 691 188 HOH HOH B . K 5 HOH 92 692 192 HOH HOH B . K 5 HOH 93 693 196 HOH HOH B . K 5 HOH 94 694 197 HOH HOH B . K 5 HOH 95 695 204 HOH HOH B . K 5 HOH 96 696 205 HOH HOH B . K 5 HOH 97 697 206 HOH HOH B . K 5 HOH 98 698 211 HOH HOH B . K 5 HOH 99 699 215 HOH HOH B . K 5 HOH 100 700 217 HOH HOH B . K 5 HOH 101 701 218 HOH HOH B . K 5 HOH 102 702 219 HOH HOH B . K 5 HOH 103 703 220 HOH HOH B . K 5 HOH 104 704 221 HOH HOH B . K 5 HOH 105 705 222 HOH HOH B . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 83 A ASN 67 ? ASN 'GLYCOSYLATION SITE' 2 B ASN 83 B ASN 67 ? ASN 'GLYCOSYLATION SITE' # loop_ _pdbx_struct_assembly.id _pdbx_struct_assembly.details _pdbx_struct_assembly.method_details _pdbx_struct_assembly.oligomeric_details _pdbx_struct_assembly.oligomeric_count 1 author_and_software_defined_assembly PISA trimeric 3 2 author_and_software_defined_assembly PISA trimeric 3 # loop_ _pdbx_struct_assembly_gen.assembly_id _pdbx_struct_assembly_gen.oper_expression _pdbx_struct_assembly_gen.asym_id_list 1 1,2,3 A,C,D,E,F,J 2 1,4,5 B,G,H,I,K # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 1 'ABSA (A^2)' 12900 ? 1 MORE -38 ? 1 'SSA (A^2)' 48860 ? 2 'ABSA (A^2)' 12590 ? 2 MORE -38 ? 2 'SSA (A^2)' 49000 ? # loop_ _pdbx_struct_oper_list.id _pdbx_struct_oper_list.type _pdbx_struct_oper_list.name _pdbx_struct_oper_list.symmetry_operation _pdbx_struct_oper_list.matrix[1][1] _pdbx_struct_oper_list.matrix[1][2] _pdbx_struct_oper_list.matrix[1][3] _pdbx_struct_oper_list.vector[1] _pdbx_struct_oper_list.matrix[2][1] _pdbx_struct_oper_list.matrix[2][2] _pdbx_struct_oper_list.matrix[2][3] _pdbx_struct_oper_list.vector[2] _pdbx_struct_oper_list.matrix[3][1] _pdbx_struct_oper_list.matrix[3][2] _pdbx_struct_oper_list.matrix[3][3] _pdbx_struct_oper_list.vector[3] 1 'identity operation' 1_555 x,y,z 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 2 'crystal symmetry operation' 2_565 -y,x-y+1,z -0.5000000000 -0.8660254038 0.0000000000 -38.9465000000 0.8660254038 -0.5000000000 0.0000000000 67.4573167770 0.0000000000 0.0000000000 1.0000000000 0.0000000000 3 'crystal symmetry operation' 3_455 -x+y-1,-x,z -0.5000000000 0.8660254038 0.0000000000 -77.8930000000 -0.8660254038 -0.5000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 4 'crystal symmetry operation' 2_455 -y-1,x-y,z -0.5000000000 -0.8660254038 0.0000000000 -77.8930000000 0.8660254038 -0.5000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 5 'crystal symmetry operation' 3_445 -x+y-1,-x-1,z -0.5000000000 0.8660254038 0.0000000000 -38.9465000000 -0.8660254038 -0.5000000000 0.0000000000 -67.4573167770 0.0000000000 0.0000000000 1.0000000000 0.0000000000 # loop_ _pdbx_struct_conn_angle.id _pdbx_struct_conn_angle.ptnr1_label_atom_id _pdbx_struct_conn_angle.ptnr1_label_alt_id _pdbx_struct_conn_angle.ptnr1_label_asym_id _pdbx_struct_conn_angle.ptnr1_label_comp_id _pdbx_struct_conn_angle.ptnr1_label_seq_id _pdbx_struct_conn_angle.ptnr1_auth_atom_id _pdbx_struct_conn_angle.ptnr1_auth_asym_id _pdbx_struct_conn_angle.ptnr1_auth_comp_id _pdbx_struct_conn_angle.ptnr1_auth_seq_id _pdbx_struct_conn_angle.ptnr1_PDB_ins_code _pdbx_struct_conn_angle.ptnr1_symmetry _pdbx_struct_conn_angle.ptnr2_label_atom_id _pdbx_struct_conn_angle.ptnr2_label_alt_id _pdbx_struct_conn_angle.ptnr2_label_asym_id _pdbx_struct_conn_angle.ptnr2_label_comp_id _pdbx_struct_conn_angle.ptnr2_label_seq_id _pdbx_struct_conn_angle.ptnr2_auth_atom_id _pdbx_struct_conn_angle.ptnr2_auth_asym_id _pdbx_struct_conn_angle.ptnr2_auth_comp_id _pdbx_struct_conn_angle.ptnr2_auth_seq_id _pdbx_struct_conn_angle.ptnr2_PDB_ins_code _pdbx_struct_conn_angle.ptnr2_symmetry _pdbx_struct_conn_angle.ptnr3_label_atom_id _pdbx_struct_conn_angle.ptnr3_label_alt_id _pdbx_struct_conn_angle.ptnr3_label_asym_id _pdbx_struct_conn_angle.ptnr3_label_comp_id _pdbx_struct_conn_angle.ptnr3_label_seq_id _pdbx_struct_conn_angle.ptnr3_auth_atom_id _pdbx_struct_conn_angle.ptnr3_auth_asym_id _pdbx_struct_conn_angle.ptnr3_auth_comp_id _pdbx_struct_conn_angle.ptnr3_auth_seq_id _pdbx_struct_conn_angle.ptnr3_PDB_ins_code _pdbx_struct_conn_angle.ptnr3_symmetry _pdbx_struct_conn_angle.value _pdbx_struct_conn_angle.value_esd 1 OD1 ? B ASP 26 ? B ASP 10 ? 1_555 CD ? H CD . ? B CD 502 ? 1_555 OD2 ? B ASP 26 ? B ASP 10 ? 1_555 52.0 ? 2 OD1 ? B ASP 26 ? B ASP 10 ? 1_555 CD ? H CD . ? B CD 502 ? 1_555 O ? K HOH . ? B HOH 641 ? 1_555 61.3 ? 3 OD2 ? B ASP 26 ? B ASP 10 ? 1_555 CD ? H CD . ? B CD 502 ? 1_555 O ? K HOH . ? B HOH 641 ? 1_555 112.8 ? 4 OE2 ? B GLU 327 ? B GLU 311 ? 1_555 CD ? D CD . ? A CD 502 ? 1_555 OE1 ? B GLU 327 ? B GLU 311 ? 1_555 52.5 ? 5 OE2 ? B GLU 327 ? B GLU 311 ? 1_555 CD ? D CD . ? A CD 502 ? 1_555 OD2 ? A ASP 114 ? A ASP 98 ? 1_555 96.0 ? 6 OE1 ? B GLU 327 ? B GLU 311 ? 1_555 CD ? D CD . ? A CD 502 ? 1_555 OD2 ? A ASP 114 ? A ASP 98 ? 1_555 148.6 ? 7 NE2 ? B HIS 43 ? B HIS 27 ? 1_555 CD ? I CD . ? B CD 503 ? 1_555 NE2 ? B HIS 298 ? B HIS 282 ? 1_555 92.8 ? 8 OD1 ? A ASP 26 ? A ASP 10 ? 1_555 CD ? E CD . ? A CD 503 ? 1_555 OD2 ? A ASP 26 ? A ASP 10 ? 1_555 51.6 ? 9 OD1 ? A ASP 26 ? A ASP 10 ? 1_555 CD ? E CD . ? A CD 503 ? 1_555 O ? J HOH . ? A HOH 637 ? 1_555 136.9 ? 10 OD2 ? A ASP 26 ? A ASP 10 ? 1_555 CD ? E CD . ? A CD 503 ? 1_555 O ? J HOH . ? A HOH 637 ? 1_555 87.7 ? 11 OD1 ? A ASP 26 ? A ASP 10 ? 1_555 CD ? E CD . ? A CD 503 ? 1_555 O ? J HOH . ? A HOH 713 ? 1_555 102.4 ? 12 OD2 ? A ASP 26 ? A ASP 10 ? 1_555 CD ? E CD . ? A CD 503 ? 1_555 O ? J HOH . ? A HOH 713 ? 1_555 153.8 ? 13 O ? J HOH . ? A HOH 637 ? 1_555 CD ? E CD . ? A CD 503 ? 1_555 O ? J HOH . ? A HOH 713 ? 1_555 118.3 ? 14 OD1 ? A ASP 26 ? A ASP 10 ? 1_555 CD ? E CD . ? A CD 503 ? 1_555 O ? J HOH . ? A HOH 620 ? 1_555 77.9 ? 15 OD2 ? A ASP 26 ? A ASP 10 ? 1_555 CD ? E CD . ? A CD 503 ? 1_555 O ? J HOH . ? A HOH 620 ? 1_555 59.5 ? 16 O ? J HOH . ? A HOH 637 ? 1_555 CD ? E CD . ? A CD 503 ? 1_555 O ? J HOH . ? A HOH 620 ? 1_555 94.0 ? 17 O ? J HOH . ? A HOH 713 ? 1_555 CD ? E CD . ? A CD 503 ? 1_555 O ? J HOH . ? A HOH 620 ? 1_555 117.8 ? # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2012-12-19 2 'Structure model' 1 1 2013-01-30 3 'Structure model' 1 2 2013-02-06 4 'Structure model' 1 3 2017-11-15 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Derived calculations' 2 3 'Structure model' 'Database references' 3 4 'Structure model' 'Refinement description' # _pdbx_audit_revision_category.ordinal 1 _pdbx_audit_revision_category.revision_ordinal 4 _pdbx_audit_revision_category.data_content_type 'Structure model' _pdbx_audit_revision_category.category software # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal HKL-2000 'data collection' . ? 1 PHENIX refinement '(phenix.refine: 1.8_1069)' ? 2 HKL-2000 'data reduction' . ? 3 HKL-2000 'data scaling' . ? 4 # loop_ _pdbx_validate_close_contact.id _pdbx_validate_close_contact.PDB_model_num _pdbx_validate_close_contact.auth_atom_id_1 _pdbx_validate_close_contact.auth_asym_id_1 _pdbx_validate_close_contact.auth_comp_id_1 _pdbx_validate_close_contact.auth_seq_id_1 _pdbx_validate_close_contact.PDB_ins_code_1 _pdbx_validate_close_contact.label_alt_id_1 _pdbx_validate_close_contact.auth_atom_id_2 _pdbx_validate_close_contact.auth_asym_id_2 _pdbx_validate_close_contact.auth_comp_id_2 _pdbx_validate_close_contact.auth_seq_id_2 _pdbx_validate_close_contact.PDB_ins_code_2 _pdbx_validate_close_contact.label_alt_id_2 _pdbx_validate_close_contact.dist 1 1 O B GLY 399 ? ? O B HOH 621 ? ? 2.05 2 1 O B GLY 399 ? ? O B HOH 653 ? ? 2.08 3 1 O B SER 29 ? ? O B HOH 626 ? ? 2.08 4 1 N B GLY 399 ? ? O B HOH 653 ? ? 2.09 5 1 ND2 B ASN 67 ? ? O5 B NAG 501 ? ? 2.10 6 1 OE2 B GLU 229 ? ? O B HOH 677 ? ? 2.11 7 1 O A THR 329 ? ? O A HOH 652 ? ? 2.12 8 1 O A THR 163 ? ? O A HOH 662 ? ? 2.13 9 1 OH A TYR 326 ? ? OD1 A ASP 330 ? ? 2.13 10 1 O A HOH 605 ? ? O A HOH 665 ? ? 2.14 11 1 OE2 B GLU 368 ? ? O B HOH 676 ? ? 2.15 12 1 O B HOH 647 ? ? O B HOH 669 ? ? 2.17 13 1 O B HOH 616 ? ? O B HOH 657 ? ? 2.18 14 1 O B HOH 608 ? ? O B HOH 630 ? ? 2.18 15 1 O A THR 242 ? ? O A HOH 676 ? ? 2.19 16 1 O B HOH 629 ? ? O B HOH 682 ? ? 2.19 # loop_ _pdbx_validate_symm_contact.id _pdbx_validate_symm_contact.PDB_model_num _pdbx_validate_symm_contact.auth_atom_id_1 _pdbx_validate_symm_contact.auth_asym_id_1 _pdbx_validate_symm_contact.auth_comp_id_1 _pdbx_validate_symm_contact.auth_seq_id_1 _pdbx_validate_symm_contact.PDB_ins_code_1 _pdbx_validate_symm_contact.label_alt_id_1 _pdbx_validate_symm_contact.site_symmetry_1 _pdbx_validate_symm_contact.auth_atom_id_2 _pdbx_validate_symm_contact.auth_asym_id_2 _pdbx_validate_symm_contact.auth_comp_id_2 _pdbx_validate_symm_contact.auth_seq_id_2 _pdbx_validate_symm_contact.PDB_ins_code_2 _pdbx_validate_symm_contact.label_alt_id_2 _pdbx_validate_symm_contact.site_symmetry_2 _pdbx_validate_symm_contact.dist 1 1 N B SER 225 ? ? 1_555 O B HOH 621 ? ? 3_445 1.99 2 1 OE2 B GLU 13 ? ? 1_555 OG B SER 16 ? ? 2_455 2.15 # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 LYS A 36 ? ? -51.12 90.41 2 1 ASP A 37 ? ? 63.03 67.76 3 1 ASP A 177 ? ? 76.21 -38.62 4 1 LYS A 202 ? ? 56.39 -93.15 5 1 ASN A 355 ? ? -115.43 79.43 6 1 LYS B 36 ? ? -43.82 107.97 7 1 THR B 76 ? ? 92.03 -4.06 8 1 ASN B 103 ? ? 29.43 54.56 9 1 ALA B 168 ? ? -110.31 77.43 10 1 ASP B 177 ? ? 70.93 -18.56 11 1 LYS B 202 ? ? 57.23 -99.38 12 1 SER B 227 ? ? -69.06 -74.78 13 1 ASP B 235 ? ? -59.60 -8.20 14 1 LYS B 291 ? ? -54.11 100.69 15 1 ASN B 355 ? ? -113.31 72.77 16 1 GLU B 362 ? ? 73.86 -8.20 # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 Y 1 B GLU 84 ? CG ? B GLU 100 CG 2 1 Y 1 B GLU 84 ? CD ? B GLU 100 CD 3 1 Y 1 B GLU 84 ? OE1 ? B GLU 100 OE1 4 1 Y 1 B GLU 84 ? OE2 ? B GLU 100 OE2 5 1 Y 1 B HIS 244 ? CG ? B HIS 260 CG 6 1 Y 1 B HIS 244 ? ND1 ? B HIS 260 ND1 7 1 Y 1 B HIS 244 ? CD2 ? B HIS 260 CD2 8 1 Y 1 B HIS 244 ? CE1 ? B HIS 260 CE1 9 1 Y 1 B HIS 244 ? NE2 ? B HIS 260 NE2 10 1 Y 1 B LYS 246 ? CG ? B LYS 262 CG 11 1 Y 1 B LYS 246 ? CD ? B LYS 262 CD 12 1 Y 1 B LYS 246 ? CE ? B LYS 262 CE 13 1 Y 1 B LYS 246 ? NZ ? B LYS 262 NZ 14 1 Y 1 B LYS 247 ? CG ? B LYS 263 CG 15 1 Y 1 B LYS 247 ? CD ? B LYS 263 CD 16 1 Y 1 B LYS 247 ? CE ? B LYS 263 CE 17 1 Y 1 B LYS 247 ? NZ ? B LYS 263 NZ 18 1 Y 1 B LYS 343 ? CG ? B LYS 359 CG 19 1 Y 1 B LYS 343 ? CD ? B LYS 359 CD 20 1 Y 1 B LYS 343 ? CE ? B LYS 359 CE 21 1 Y 1 B LYS 343 ? NZ ? B LYS 359 NZ 22 1 Y 1 B GLU 362 ? CG ? B GLU 378 CG 23 1 Y 1 B GLU 362 ? CD ? B GLU 378 CD 24 1 Y 1 B GLU 362 ? OE1 ? B GLU 378 OE1 25 1 Y 1 B GLU 362 ? OE2 ? B GLU 378 OE2 26 1 Y 1 B LYS 385 ? CG ? B LYS 401 CG 27 1 Y 1 B LYS 385 ? CD ? B LYS 401 CD 28 1 Y 1 B LYS 385 ? CE ? B LYS 401 CE 29 1 Y 1 B LYS 385 ? NZ ? B LYS 401 NZ # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A GLY -15 ? A GLY 1 2 1 Y 1 A HIS -14 ? A HIS 2 3 1 Y 1 A HIS -13 ? A HIS 3 4 1 Y 1 A HIS -12 ? A HIS 4 5 1 Y 1 A HIS -11 ? A HIS 5 6 1 Y 1 A HIS -10 ? A HIS 6 7 1 Y 1 A HIS -9 ? A HIS 7 8 1 Y 1 A HIS -8 ? A HIS 8 9 1 Y 1 A HIS -7 ? A HIS 9 10 1 Y 1 A GLY -6 ? A GLY 10 11 1 Y 1 A SER -5 ? A SER 11 12 1 Y 1 A SER -4 ? A SER 12 13 1 Y 1 A THR -3 ? A THR 13 14 1 Y 1 A SER -2 ? A SER 14 15 1 Y 1 A ASN -1 ? A ASN 15 16 1 Y 1 A GLY 0 ? A GLY 16 17 1 Y 1 A MET 1 ? A MET 17 18 1 Y 1 A ASP 147 ? A ASP 163 19 1 Y 1 A GLN 148 ? A GLN 164 20 1 Y 1 A HIS 149 ? A HIS 165 21 1 Y 1 A GLN 150 ? A GLN 166 22 1 Y 1 A VAL 151 ? A VAL 167 23 1 Y 1 A GLY 152 ? A GLY 168 24 1 Y 1 A ASN 153 ? A ASN 169 25 1 Y 1 A GLU 154 ? A GLU 170 26 1 Y 1 A THR 155 ? A THR 171 27 1 Y 1 A THR 156 ? A THR 172 28 1 Y 1 A GLU 157 ? A GLU 173 29 1 Y 1 A HIS 158 ? A HIS 174 30 1 Y 1 A ALA 404 ? A ALA 420 31 1 Y 1 A THR 405 ? A THR 421 32 1 Y 1 A ALA 406 ? A ALA 422 33 1 Y 1 A ARG 407 ? A ARG 423 34 1 Y 1 A GLY 408 ? A GLY 424 35 1 Y 1 A ALA 409 ? A ALA 425 36 1 Y 1 A ARG 410 ? A ARG 426 37 1 Y 1 A ARG 411 ? A ARG 427 38 1 Y 1 A MET 412 ? A MET 428 39 1 Y 1 A ALA 413 ? A ALA 429 40 1 Y 1 A ILE 414 ? A ILE 430 41 1 Y 1 A LEU 415 ? A LEU 431 42 1 Y 1 A GLY 416 ? A GLY 432 43 1 Y 1 A ASP 417 ? A ASP 433 44 1 Y 1 A THR 418 ? A THR 434 45 1 Y 1 A ALA 419 ? A ALA 435 46 1 Y 1 A TRP 420 ? A TRP 436 47 1 Y 1 A ASP 421 ? A ASP 437 48 1 Y 1 B GLY -15 ? B GLY 1 49 1 Y 1 B HIS -14 ? B HIS 2 50 1 Y 1 B HIS -13 ? B HIS 3 51 1 Y 1 B HIS -12 ? B HIS 4 52 1 Y 1 B HIS -11 ? B HIS 5 53 1 Y 1 B HIS -10 ? B HIS 6 54 1 Y 1 B HIS -9 ? B HIS 7 55 1 Y 1 B HIS -8 ? B HIS 8 56 1 Y 1 B HIS -7 ? B HIS 9 57 1 Y 1 B GLY -6 ? B GLY 10 58 1 Y 1 B SER -5 ? B SER 11 59 1 Y 1 B SER -4 ? B SER 12 60 1 Y 1 B THR -3 ? B THR 13 61 1 Y 1 B SER -2 ? B SER 14 62 1 Y 1 B ASN -1 ? B ASN 15 63 1 Y 1 B GLY 0 ? B GLY 16 64 1 Y 1 B MET 1 ? B MET 17 65 1 Y 1 B HIS 101 ? B HIS 117 66 1 Y 1 B GLY 146 ? B GLY 162 67 1 Y 1 B ASP 147 ? B ASP 163 68 1 Y 1 B GLN 148 ? B GLN 164 69 1 Y 1 B HIS 149 ? B HIS 165 70 1 Y 1 B GLN 150 ? B GLN 166 71 1 Y 1 B VAL 151 ? B VAL 167 72 1 Y 1 B GLY 152 ? B GLY 168 73 1 Y 1 B ASN 153 ? B ASN 169 74 1 Y 1 B GLU 154 ? B GLU 170 75 1 Y 1 B THR 155 ? B THR 171 76 1 Y 1 B THR 156 ? B THR 172 77 1 Y 1 B GLU 157 ? B GLU 173 78 1 Y 1 B THR 405 ? B THR 421 79 1 Y 1 B ALA 406 ? B ALA 422 80 1 Y 1 B ARG 407 ? B ARG 423 81 1 Y 1 B GLY 408 ? B GLY 424 82 1 Y 1 B ALA 409 ? B ALA 425 83 1 Y 1 B ARG 410 ? B ARG 426 84 1 Y 1 B ARG 411 ? B ARG 427 85 1 Y 1 B MET 412 ? B MET 428 86 1 Y 1 B ALA 413 ? B ALA 429 87 1 Y 1 B ILE 414 ? B ILE 430 88 1 Y 1 B LEU 415 ? B LEU 431 89 1 Y 1 B GLY 416 ? B GLY 432 90 1 Y 1 B ASP 417 ? B ASP 433 91 1 Y 1 B THR 418 ? B THR 434 92 1 Y 1 B ALA 419 ? B ALA 435 93 1 Y 1 B TRP 420 ? B TRP 436 94 1 Y 1 B ASP 421 ? B ASP 437 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 'CADMIUM ION' CD 4 'CHLORIDE ION' CL 5 water HOH # _pdbx_reflns_twin.domain_id ? _pdbx_reflns_twin.crystal_id 1 _pdbx_reflns_twin.diffrn_id 1 _pdbx_reflns_twin.type merohedral _pdbx_reflns_twin.operator h,-h-k,-l _pdbx_reflns_twin.fraction 0.500 #