data_4AA2 # _entry.id 4AA2 # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 4AA2 PDBE EBI-50530 WWPDB D_1290050530 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.content_type _pdbx_database_related.details PDB 2X94 unspecified 'CRYSTAL STRUCTURE OF ANCE-PERINDOPRILAT COMPLEX' PDB 1J38 unspecified 'CRYSTAL STRUCTURE OF DROSOPHILA ANCE' PDB 2X8Z unspecified 'CRYSTAL STRUCTURE OF ANCE-CAPTOPRIL COMPLEX' PDB 1J36 unspecified 'CRYSTAL STRUCTURE OF DROSOPHILA ANCE' PDB 2XHM unspecified 'CRYSTAL STRUCTURE OF ANCE-K26 COMPLEX' PDB 2X8Y unspecified 'CRYSTAL STRUCTURE OF ANCE' PDB 2X91 unspecified 'CRYSTAL STRUCTURE OF ANCE-LISINOPRIL COMPLEX' PDB 2X95 unspecified ;CRYSTAL STRUCTURE OF ANCE-LISINOPRIL-TRYPTOPHAN ANALOGUE' LISW-S COMPLEX ; PDB 2X96 unspecified 'CRYSTAL STRUCTURE OF ANCE-RXPA380 COMPLEX' PDB 2X92 unspecified 'CRYSTAL STRUCTURE OF ANCE-RAMIPRILAT COMPLEX' PDB 2X97 unspecified 'CRYSTAL STRUCTURE OF ANCE-RXP407 COMPLEX' PDB 2X93 unspecified 'CRYSTAL STRUCTURE OF ANCE-TRANDOLAPRILAT COMPLEX' PDB 3ZQZ unspecified 'CRYSTAL STRUCTURE OF ANCE IN COMPLEX WITH A SELENIUM ANALOGUE OF CAPTOPRIL' PDB 2X90 unspecified 'CRYSTAL STRUCTURE OF ANCE-ENALAPRILAT COMPLEX' PDB 1J37 unspecified 'CRYSTAL STRUCTURE OF DROSOPHILA ANCE' PDB 4AA1 unspecified 'CRYSTAL STRUCTURE OF ANCE IN COMPLEX WITH ANGIOTENSIN-II' # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 4AA2 _pdbx_database_status.deposit_site PDBE _pdbx_database_status.process_site PDBE _pdbx_database_status.SG_entry . _pdbx_database_status.recvd_initial_deposition_date 2011-11-30 _pdbx_database_status.pdb_format_compatible Y _pdbx_database_status.status_code_sf ? _pdbx_database_status.status_code_mr ? _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Isaac, R.E.' 1 'Akif, M.' 2 'Schwager, S.L.U.' 3 'Masuyer, G.' 4 'Sturrock, E.D.' 5 'Acharya, K.R.' 6 # _citation.id primary _citation.title 'Structural Basis of Peptide Recognition by the Angiotensin-I Converting Enzyme Homologue Ance from Drosophila Melanogaster' _citation.journal_abbrev 'FEBS J.' _citation.journal_volume 279 _citation.page_first 4525 _citation.page_last ? _citation.year 2012 _citation.journal_id_ASTM ? _citation.country UK _citation.journal_id_ISSN 1742-464X _citation.journal_id_CSD ? _citation.book_publisher ? _citation.pdbx_database_id_PubMed 23082758 _citation.pdbx_database_id_DOI 10.1111/FEBS.12038 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Akif, M.' 1 primary 'Masuyer, G.' 2 primary 'Bingham, R.J.' 3 primary 'Sturrock, E.D.' 4 primary 'Isaac, R.E.' 5 primary 'Acharya, K.R.' 6 # _cell.entry_id 4AA2 _cell.length_a 173.214 _cell.length_b 173.214 _cell.length_c 102.898 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 120.00 _cell.Z_PDB 9 _cell.pdbx_unique_axis ? # _symmetry.entry_id 4AA2 _symmetry.space_group_name_H-M 'H 3' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 146 # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'ANGIOTENSIN-CONVERTING ENZYME' 69152.602 1 3.4.15.1 ? 'RESIDUES 17-614' ? 2 polymer syn 'BRADYKININ-POTENTIATING PEPTIDE B' 1202.444 1 ? ? ? ? 3 non-polymer syn 'ZINC ION' 65.409 1 ? ? ? ? 4 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 4 ? ? ? ? 5 non-polymer man BETA-D-MANNOSE 180.156 2 ? ? ? ? 6 non-polymer man ALPHA-D-MANNOSE 180.156 2 ? ? ? ? 7 water nat water 18.015 417 ? ? ? ? # _entity_name_com.entity_id 2 _entity_name_com.name 'POTENTIATOR B' # loop_ _entity_poly.entity_id _entity_poly.type _entity_poly.nstd_linkage _entity_poly.nstd_monomer _entity_poly.pdbx_seq_one_letter_code _entity_poly.pdbx_seq_one_letter_code_can _entity_poly.pdbx_strand_id _entity_poly.pdbx_target_identifier 1 'polypeptide(L)' no no ;ALVKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQ FKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTA VRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPM HLLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVC HASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGL LKDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKY HISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERI MSGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNKCVS ; ;ALVKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQ FKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTA VRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPM HLLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVC HASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGL LKDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKY HISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERI MSGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNKCVS ; A ? 2 'polypeptide(L)' no no EGLPPRPKIPP EGLPPRPKIPP P ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 ALA n 1 2 LEU n 1 3 VAL n 1 4 LYS n 1 5 GLU n 1 6 GLU n 1 7 ILE n 1 8 GLN n 1 9 ALA n 1 10 LYS n 1 11 GLU n 1 12 TYR n 1 13 LEU n 1 14 GLU n 1 15 ASN n 1 16 LEU n 1 17 ASN n 1 18 LYS n 1 19 GLU n 1 20 LEU n 1 21 ALA n 1 22 LYS n 1 23 ARG n 1 24 THR n 1 25 ASN n 1 26 VAL n 1 27 GLU n 1 28 THR n 1 29 GLU n 1 30 ALA n 1 31 ALA n 1 32 TRP n 1 33 ALA n 1 34 TYR n 1 35 GLY n 1 36 SER n 1 37 ASN n 1 38 ILE n 1 39 THR n 1 40 ASP n 1 41 GLU n 1 42 ASN n 1 43 GLU n 1 44 LYS n 1 45 LYS n 1 46 LYS n 1 47 ASN n 1 48 GLU n 1 49 ILE n 1 50 SER n 1 51 ALA n 1 52 GLU n 1 53 LEU n 1 54 ALA n 1 55 LYS n 1 56 PHE n 1 57 MET n 1 58 LYS n 1 59 GLU n 1 60 VAL n 1 61 ALA n 1 62 SER n 1 63 ASP n 1 64 THR n 1 65 THR n 1 66 LYS n 1 67 PHE n 1 68 GLN n 1 69 TRP n 1 70 ARG n 1 71 SER n 1 72 TYR n 1 73 GLN n 1 74 SER n 1 75 GLU n 1 76 ASP n 1 77 LEU n 1 78 LYS n 1 79 ARG n 1 80 GLN n 1 81 PHE n 1 82 LYS n 1 83 ALA n 1 84 LEU n 1 85 THR n 1 86 LYS n 1 87 LEU n 1 88 GLY n 1 89 TYR n 1 90 ALA n 1 91 ALA n 1 92 LEU n 1 93 PRO n 1 94 GLU n 1 95 ASP n 1 96 ASP n 1 97 TYR n 1 98 ALA n 1 99 GLU n 1 100 LEU n 1 101 LEU n 1 102 ASP n 1 103 THR n 1 104 LEU n 1 105 SER n 1 106 ALA n 1 107 MET n 1 108 GLU n 1 109 SER n 1 110 ASN n 1 111 PHE n 1 112 ALA n 1 113 LYS n 1 114 VAL n 1 115 LYS n 1 116 VAL n 1 117 CYS n 1 118 ASP n 1 119 TYR n 1 120 LYS n 1 121 ASP n 1 122 SER n 1 123 THR n 1 124 LYS n 1 125 CYS n 1 126 ASP n 1 127 LEU n 1 128 ALA n 1 129 LEU n 1 130 ASP n 1 131 PRO n 1 132 GLU n 1 133 ILE n 1 134 GLU n 1 135 GLU n 1 136 VAL n 1 137 ILE n 1 138 SER n 1 139 LYS n 1 140 SER n 1 141 ARG n 1 142 ASP n 1 143 HIS n 1 144 GLU n 1 145 GLU n 1 146 LEU n 1 147 ALA n 1 148 TYR n 1 149 TYR n 1 150 TRP n 1 151 ARG n 1 152 GLU n 1 153 PHE n 1 154 TYR n 1 155 ASP n 1 156 LYS n 1 157 ALA n 1 158 GLY n 1 159 THR n 1 160 ALA n 1 161 VAL n 1 162 ARG n 1 163 SER n 1 164 GLN n 1 165 PHE n 1 166 GLU n 1 167 ARG n 1 168 TYR n 1 169 VAL n 1 170 GLU n 1 171 LEU n 1 172 ASN n 1 173 THR n 1 174 LYS n 1 175 ALA n 1 176 ALA n 1 177 LYS n 1 178 LEU n 1 179 ASN n 1 180 ASN n 1 181 PHE n 1 182 THR n 1 183 SER n 1 184 GLY n 1 185 ALA n 1 186 GLU n 1 187 ALA n 1 188 TRP n 1 189 LEU n 1 190 ASP n 1 191 GLU n 1 192 TYR n 1 193 GLU n 1 194 ASP n 1 195 ASP n 1 196 THR n 1 197 PHE n 1 198 GLU n 1 199 GLN n 1 200 GLN n 1 201 LEU n 1 202 GLU n 1 203 ASP n 1 204 ILE n 1 205 PHE n 1 206 ALA n 1 207 ASP n 1 208 ILE n 1 209 ARG n 1 210 PRO n 1 211 LEU n 1 212 TYR n 1 213 GLN n 1 214 GLN n 1 215 ILE n 1 216 HIS n 1 217 GLY n 1 218 TYR n 1 219 VAL n 1 220 ARG n 1 221 PHE n 1 222 ARG n 1 223 LEU n 1 224 ARG n 1 225 LYS n 1 226 HIS n 1 227 TYR n 1 228 GLY n 1 229 ASP n 1 230 ALA n 1 231 VAL n 1 232 VAL n 1 233 SER n 1 234 GLU n 1 235 THR n 1 236 GLY n 1 237 PRO n 1 238 ILE n 1 239 PRO n 1 240 MET n 1 241 HIS n 1 242 LEU n 1 243 LEU n 1 244 GLY n 1 245 ASN n 1 246 MET n 1 247 TRP n 1 248 ALA n 1 249 GLN n 1 250 GLN n 1 251 TRP n 1 252 SER n 1 253 GLU n 1 254 ILE n 1 255 ALA n 1 256 ASP n 1 257 ILE n 1 258 VAL n 1 259 SER n 1 260 PRO n 1 261 PHE n 1 262 PRO n 1 263 GLU n 1 264 LYS n 1 265 PRO n 1 266 LEU n 1 267 VAL n 1 268 ASP n 1 269 VAL n 1 270 SER n 1 271 ALA n 1 272 GLU n 1 273 MET n 1 274 GLU n 1 275 LYS n 1 276 GLN n 1 277 GLY n 1 278 TYR n 1 279 THR n 1 280 PRO n 1 281 LEU n 1 282 LYS n 1 283 MET n 1 284 PHE n 1 285 GLN n 1 286 MET n 1 287 GLY n 1 288 ASP n 1 289 ASP n 1 290 PHE n 1 291 PHE n 1 292 THR n 1 293 SER n 1 294 MET n 1 295 ASN n 1 296 LEU n 1 297 THR n 1 298 LYS n 1 299 LEU n 1 300 PRO n 1 301 GLN n 1 302 ASP n 1 303 PHE n 1 304 TRP n 1 305 ASP n 1 306 LYS n 1 307 SER n 1 308 ILE n 1 309 ILE n 1 310 GLU n 1 311 LYS n 1 312 PRO n 1 313 THR n 1 314 ASP n 1 315 GLY n 1 316 ARG n 1 317 ASP n 1 318 LEU n 1 319 VAL n 1 320 CYS n 1 321 HIS n 1 322 ALA n 1 323 SER n 1 324 ALA n 1 325 TRP n 1 326 ASP n 1 327 PHE n 1 328 TYR n 1 329 LEU n 1 330 THR n 1 331 ASP n 1 332 ASP n 1 333 VAL n 1 334 ARG n 1 335 ILE n 1 336 LYS n 1 337 GLN n 1 338 CYS n 1 339 THR n 1 340 ARG n 1 341 VAL n 1 342 THR n 1 343 GLN n 1 344 ASP n 1 345 GLN n 1 346 LEU n 1 347 PHE n 1 348 THR n 1 349 VAL n 1 350 HIS n 1 351 HIS n 1 352 GLU n 1 353 LEU n 1 354 GLY n 1 355 HIS n 1 356 ILE n 1 357 GLN n 1 358 TYR n 1 359 PHE n 1 360 LEU n 1 361 GLN n 1 362 TYR n 1 363 GLN n 1 364 HIS n 1 365 GLN n 1 366 PRO n 1 367 PHE n 1 368 VAL n 1 369 TYR n 1 370 ARG n 1 371 THR n 1 372 GLY n 1 373 ALA n 1 374 ASN n 1 375 PRO n 1 376 GLY n 1 377 PHE n 1 378 HIS n 1 379 GLU n 1 380 ALA n 1 381 VAL n 1 382 GLY n 1 383 ASP n 1 384 VAL n 1 385 LEU n 1 386 SER n 1 387 LEU n 1 388 SER n 1 389 VAL n 1 390 SER n 1 391 THR n 1 392 PRO n 1 393 LYS n 1 394 HIS n 1 395 LEU n 1 396 GLU n 1 397 LYS n 1 398 ILE n 1 399 GLY n 1 400 LEU n 1 401 LEU n 1 402 LYS n 1 403 ASP n 1 404 TYR n 1 405 VAL n 1 406 ARG n 1 407 ASP n 1 408 ASP n 1 409 GLU n 1 410 ALA n 1 411 ARG n 1 412 ILE n 1 413 ASN n 1 414 GLN n 1 415 LEU n 1 416 PHE n 1 417 LEU n 1 418 THR n 1 419 ALA n 1 420 LEU n 1 421 ASP n 1 422 LYS n 1 423 ILE n 1 424 VAL n 1 425 PHE n 1 426 LEU n 1 427 PRO n 1 428 PHE n 1 429 ALA n 1 430 PHE n 1 431 THR n 1 432 MET n 1 433 ASP n 1 434 LYS n 1 435 TYR n 1 436 ARG n 1 437 TRP n 1 438 SER n 1 439 LEU n 1 440 PHE n 1 441 ARG n 1 442 GLY n 1 443 GLU n 1 444 VAL n 1 445 ASP n 1 446 LYS n 1 447 ALA n 1 448 ASN n 1 449 TRP n 1 450 ASN n 1 451 CYS n 1 452 ALA n 1 453 PHE n 1 454 TRP n 1 455 LYS n 1 456 LEU n 1 457 ARG n 1 458 ASP n 1 459 GLU n 1 460 TYR n 1 461 SER n 1 462 GLY n 1 463 ILE n 1 464 GLU n 1 465 PRO n 1 466 PRO n 1 467 VAL n 1 468 VAL n 1 469 ARG n 1 470 SER n 1 471 GLU n 1 472 LYS n 1 473 ASP n 1 474 PHE n 1 475 ASP n 1 476 ALA n 1 477 PRO n 1 478 ALA n 1 479 LYS n 1 480 TYR n 1 481 HIS n 1 482 ILE n 1 483 SER n 1 484 ALA n 1 485 ASP n 1 486 VAL n 1 487 GLU n 1 488 TYR n 1 489 LEU n 1 490 ARG n 1 491 TYR n 1 492 LEU n 1 493 VAL n 1 494 SER n 1 495 PHE n 1 496 ILE n 1 497 ILE n 1 498 GLN n 1 499 PHE n 1 500 GLN n 1 501 PHE n 1 502 TYR n 1 503 LYS n 1 504 SER n 1 505 ALA n 1 506 CYS n 1 507 ILE n 1 508 LYS n 1 509 ALA n 1 510 GLY n 1 511 GLN n 1 512 TYR n 1 513 ASP n 1 514 PRO n 1 515 ASP n 1 516 ASN n 1 517 VAL n 1 518 GLU n 1 519 LEU n 1 520 PRO n 1 521 LEU n 1 522 ASP n 1 523 ASN n 1 524 CYS n 1 525 ASP n 1 526 ILE n 1 527 TYR n 1 528 GLY n 1 529 SER n 1 530 ALA n 1 531 ALA n 1 532 ALA n 1 533 GLY n 1 534 ALA n 1 535 ALA n 1 536 PHE n 1 537 HIS n 1 538 ASN n 1 539 MET n 1 540 LEU n 1 541 SER n 1 542 MET n 1 543 GLY n 1 544 ALA n 1 545 SER n 1 546 LYS n 1 547 PRO n 1 548 TRP n 1 549 PRO n 1 550 ASP n 1 551 ALA n 1 552 LEU n 1 553 GLU n 1 554 ALA n 1 555 PHE n 1 556 ASN n 1 557 GLY n 1 558 GLU n 1 559 ARG n 1 560 ILE n 1 561 MET n 1 562 SER n 1 563 GLY n 1 564 LYS n 1 565 ALA n 1 566 ILE n 1 567 ALA n 1 568 GLU n 1 569 TYR n 1 570 PHE n 1 571 GLU n 1 572 PRO n 1 573 LEU n 1 574 ARG n 1 575 VAL n 1 576 TRP n 1 577 LEU n 1 578 GLU n 1 579 ALA n 1 580 GLU n 1 581 ASN n 1 582 ILE n 1 583 LYS n 1 584 ASN n 1 585 ASN n 1 586 VAL n 1 587 HIS n 1 588 ILE n 1 589 GLY n 1 590 TRP n 1 591 THR n 1 592 THR n 1 593 SER n 1 594 ASN n 1 595 LYS n 1 596 CYS n 1 597 VAL n 1 598 SER n 2 1 GLU n 2 2 GLY n 2 3 LEU n 2 4 PRO n 2 5 PRO n 2 6 ARG n 2 7 PRO n 2 8 LYS n 2 9 ILE n 2 10 PRO n 2 11 PRO n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name 'FRUIT FLY' _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene ? _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'DROSOPHILA MELANOGASTER' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 7227 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'PICHIA PASTORIS' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 644223 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain GS115 _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type ? _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name PPIC9 _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _pdbx_entity_src_syn.entity_id 2 _pdbx_entity_src_syn.pdbx_src_id 1 _pdbx_entity_src_syn.pdbx_alt_source_flag sample _pdbx_entity_src_syn.pdbx_beg_seq_num ? _pdbx_entity_src_syn.pdbx_end_seq_num ? _pdbx_entity_src_syn.organism_scientific 'GLOYDIUS BLOMHOFFI' _pdbx_entity_src_syn.organism_common_name ? _pdbx_entity_src_syn.ncbi_taxonomy_id 242054 _pdbx_entity_src_syn.details ? # loop_ _struct_ref.id _struct_ref.db_name _struct_ref.db_code _struct_ref.entity_id _struct_ref.pdbx_seq_one_letter_code _struct_ref.pdbx_align_begin _struct_ref.pdbx_db_accession _struct_ref.pdbx_db_isoform 1 UNP ACE_DROME 1 ? ? Q10714 ? 2 UNP BNP_GLOBL 2 ? ? P01021 ? # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 4AA2 A 1 ? 598 ? Q10714 17 ? 614 ? 17 614 2 2 4AA2 P 1 ? 11 ? P01021 85 ? 95 ? 1 11 # _struct_ref_seq_dif.align_id 2 _struct_ref_seq_dif.pdbx_pdb_id_code 4AA2 _struct_ref_seq_dif.mon_id GLU _struct_ref_seq_dif.pdbx_pdb_strand_id P _struct_ref_seq_dif.seq_num 1 _struct_ref_seq_dif.pdbx_pdb_ins_code ? _struct_ref_seq_dif.pdbx_seq_db_name UNP _struct_ref_seq_dif.pdbx_seq_db_accession_code P01021 _struct_ref_seq_dif.db_mon_id GLN _struct_ref_seq_dif.pdbx_seq_db_seq_num 85 _struct_ref_seq_dif.details conflict _struct_ref_seq_dif.pdbx_auth_seq_num 1 _struct_ref_seq_dif.pdbx_ordinal 1 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 BMA D-saccharide . BETA-D-MANNOSE ? 'C6 H12 O6' 180.156 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MAN D-saccharide . ALPHA-D-MANNOSE ? 'C6 H12 O6' 180.156 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 ZN non-polymer . 'ZINC ION' ? 'Zn 2' 65.409 # _exptl.entry_id 4AA2 _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 4.3 _exptl_crystal.density_percent_sol 71 _exptl_crystal.description NONE # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method ? _exptl_crystal_grow.temp ? _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 7.5 _exptl_crystal_grow.pdbx_pH_range ? _exptl_crystal_grow.pdbx_details '0.1 M HEPES 7.5, 1.3 M SODIUM CITRATE' # _diffrn.id 1 _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type 'ADSC CCD' _diffrn_detector.pdbx_collection_date 2010-05-09 _diffrn_detector.details ? # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator ? _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.9763 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'DIAMOND BEAMLINE I03' _diffrn_source.pdbx_synchrotron_site Diamond _diffrn_source.pdbx_synchrotron_beamline I03 _diffrn_source.pdbx_wavelength 0.9763 _diffrn_source.pdbx_wavelength_list ? # _reflns.pdbx_diffrn_id 1 _reflns.pdbx_ordinal 1 _reflns.entry_id 4AA2 _reflns.observed_criterion_sigma_I 0.0 _reflns.observed_criterion_sigma_F ? _reflns.d_resolution_low 50.00 _reflns.d_resolution_high 1.99 _reflns.number_obs 78895 _reflns.number_all ? _reflns.percent_possible_obs 90.3 _reflns.pdbx_Rmerge_I_obs 0.05 _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI 18.20 _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy 2.6 # _reflns_shell.pdbx_diffrn_id 1 _reflns_shell.pdbx_ordinal 1 _reflns_shell.d_res_high 1.99 _reflns_shell.d_res_low 2.06 _reflns_shell.percent_possible_all 85.3 _reflns_shell.Rmerge_I_obs 0.23 _reflns_shell.pdbx_Rsym_value ? _reflns_shell.meanI_over_sigI_obs 3.50 _reflns_shell.pdbx_redundancy 2.3 # _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.entry_id 4AA2 _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.ls_number_reflns_obs 67576 _refine.ls_number_reflns_all ? _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F . _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 38.10 _refine.ls_d_res_high 1.99 _refine.ls_percent_reflns_obs 90.16 _refine.ls_R_factor_obs 0.20443 _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work 0.20325 _refine.ls_R_factor_R_free 0.22578 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 5.0 _refine.ls_number_reflns_R_free 3561 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc 0.958 _refine.correlation_coeff_Fo_to_Fc_free 0.950 _refine.B_iso_mean 37.556 _refine.aniso_B[1][1] 0.00 _refine.aniso_B[2][2] 0.00 _refine.aniso_B[3][3] 0.00 _refine.aniso_B[1][2] 0.00 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_details MASK _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.40 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details 'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. ONLY RESIDUES ARG6 TO PRO11 OF BPPB WERE VISIBLE' _refine.pdbx_starting_model 'PDB ENTRY 2X8Y' _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R 0.147 _refine.pdbx_overall_ESU_R_Free 0.134 _refine.overall_SU_ML 0.101 _refine.pdbx_overall_phase_error ? _refine.overall_SU_B 3.841 _refine.overall_SU_R_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 4923 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 101 _refine_hist.number_atoms_solvent 417 _refine_hist.number_atoms_total 5441 _refine_hist.d_res_high 1.99 _refine_hist.d_res_low 38.10 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function r_bond_refined_d 0.007 0.022 ? 5175 'X-RAY DIFFRACTION' ? r_bond_other_d ? ? ? ? 'X-RAY DIFFRACTION' ? r_angle_refined_deg 1.027 1.967 ? 7030 'X-RAY DIFFRACTION' ? r_angle_other_deg ? ? ? ? 'X-RAY DIFFRACTION' ? r_dihedral_angle_1_deg 4.969 5.000 ? 606 'X-RAY DIFFRACTION' ? r_dihedral_angle_2_deg 35.488 24.677 ? 263 'X-RAY DIFFRACTION' ? r_dihedral_angle_3_deg 12.621 15.000 ? 863 'X-RAY DIFFRACTION' ? r_dihedral_angle_4_deg 14.370 15.000 ? 25 'X-RAY DIFFRACTION' ? r_chiral_restr 0.076 0.200 ? 758 'X-RAY DIFFRACTION' ? r_gen_planes_refined 0.004 0.021 ? 3963 'X-RAY DIFFRACTION' ? r_gen_planes_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbd_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcbond_it 0.359 1.500 ? 3026 'X-RAY DIFFRACTION' ? r_mcbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcangle_it 0.702 2.000 ? 4878 'X-RAY DIFFRACTION' ? r_mcangle_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_scbond_it 1.067 3.000 ? 2149 'X-RAY DIFFRACTION' ? r_scbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_scangle_it 1.818 4.500 ? 2150 'X-RAY DIFFRACTION' ? r_scangle_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_long_range_B_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_long_range_B_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_rigid_bond_restr ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_free ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_bonded ? ? ? ? 'X-RAY DIFFRACTION' ? # _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.d_res_high 1.990 _refine_ls_shell.d_res_low 2.042 _refine_ls_shell.number_reflns_R_work 4593 _refine_ls_shell.R_factor_R_work 0.333 _refine_ls_shell.percent_reflns_obs 83.26 _refine_ls_shell.R_factor_R_free 0.370 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.number_reflns_R_free 246 _refine_ls_shell.number_reflns_all ? _refine_ls_shell.R_factor_all ? # _struct.entry_id 4AA2 _struct.title 'Crystal structure of ANCE in complex with bradykinin potentiating peptide b' _struct.pdbx_descriptor 'ANGIOTENSIN-CONVERTING ENZYME (E.C.3.4.15.1), BRADYKININ-POTENTIATING PEPTIDE B' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 4AA2 _struct_keywords.pdbx_keywords HYDROLASE/PEPTIDE _struct_keywords.text 'HYDROLASE-PEPTIDE COMPLEX, HYDROLASE, SUBSTRATE BINDING, INHIBITOR' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 3 ? D N N 4 ? E N N 4 ? F N N 5 ? G N N 6 ? H N N 6 ? I N N 5 ? J N N 4 ? K N N 4 ? L N N 7 ? M N N 7 ? # _struct_biol.id 1 # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 ALA A 1 ? ASN A 37 ? ALA A 17 ASN A 53 1 ? 37 HELX_P HELX_P2 2 THR A 39 ? THR A 65 ? THR A 55 THR A 81 1 ? 27 HELX_P HELX_P3 3 GLN A 68 ? TYR A 72 ? GLN A 84 TYR A 88 5 ? 5 HELX_P HELX_P4 4 SER A 74 ? LYS A 86 ? SER A 90 LYS A 102 1 ? 13 HELX_P HELX_P5 5 LEU A 87 ? LEU A 92 ? LEU A 103 LEU A 108 5 ? 6 HELX_P HELX_P6 6 PRO A 93 ? LYS A 113 ? PRO A 109 LYS A 129 1 ? 21 HELX_P HELX_P7 7 PRO A 131 ? SER A 140 ? PRO A 147 SER A 156 1 ? 10 HELX_P HELX_P8 8 ASP A 142 ? GLY A 158 ? ASP A 158 GLY A 174 1 ? 17 HELX_P HELX_P9 9 VAL A 161 ? ASN A 179 ? VAL A 177 ASN A 195 1 ? 19 HELX_P HELX_P10 10 SER A 183 ? ASP A 190 ? SER A 199 ASP A 206 1 ? 8 HELX_P HELX_P11 11 GLU A 191 ? GLU A 193 ? GLU A 207 GLU A 209 5 ? 3 HELX_P HELX_P12 12 THR A 196 ? GLY A 228 ? THR A 212 GLY A 244 1 ? 33 HELX_P HELX_P13 13 HIS A 241 ? LEU A 243 ? HIS A 257 LEU A 259 5 ? 3 HELX_P HELX_P14 14 TRP A 251 ? GLU A 253 ? TRP A 267 GLU A 269 5 ? 3 HELX_P HELX_P15 15 ILE A 254 ? SER A 259 ? ILE A 270 SER A 275 1 ? 6 HELX_P HELX_P16 16 VAL A 269 ? GLN A 276 ? VAL A 285 GLN A 292 1 ? 8 HELX_P HELX_P17 17 THR A 279 ? MET A 294 ? THR A 295 MET A 310 1 ? 16 HELX_P HELX_P18 18 PRO A 300 ? SER A 307 ? PRO A 316 SER A 323 1 ? 8 HELX_P HELX_P19 19 THR A 342 ? GLN A 363 ? THR A 358 GLN A 379 1 ? 22 HELX_P HELX_P20 20 PRO A 366 ? ARG A 370 ? PRO A 382 ARG A 386 5 ? 5 HELX_P HELX_P21 21 ASN A 374 ? SER A 390 ? ASN A 390 SER A 406 1 ? 17 HELX_P HELX_P22 22 THR A 391 ? ILE A 398 ? THR A 407 ILE A 414 1 ? 8 HELX_P HELX_P23 23 ASP A 407 ? ILE A 423 ? ASP A 423 ILE A 439 1 ? 17 HELX_P HELX_P24 24 VAL A 424 ? ARG A 441 ? VAL A 440 ARG A 457 1 ? 18 HELX_P HELX_P25 25 ASP A 445 ? ALA A 447 ? ASP A 461 ALA A 463 5 ? 3 HELX_P HELX_P26 26 ASN A 448 ? GLY A 462 ? ASN A 464 GLY A 478 1 ? 15 HELX_P HELX_P27 27 ASP A 475 ? ALA A 478 ? ASP A 491 ALA A 494 5 ? 4 HELX_P HELX_P28 28 LYS A 479 ? ALA A 484 ? LYS A 495 ALA A 500 1 ? 6 HELX_P HELX_P29 29 TYR A 488 ? ALA A 509 ? TYR A 504 ALA A 525 1 ? 22 HELX_P HELX_P30 30 PRO A 520 ? CYS A 524 ? PRO A 536 CYS A 540 5 ? 5 HELX_P HELX_P31 31 SER A 529 ? SER A 541 ? SER A 545 SER A 557 1 ? 13 HELX_P HELX_P32 32 PRO A 547 ? GLY A 557 ? PRO A 563 GLY A 573 1 ? 11 HELX_P HELX_P33 33 GLY A 563 ? ASN A 584 ? GLY A 579 ASN A 600 1 ? 22 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 117 SG ? ? ? 1_555 A CYS 125 SG ? ? A CYS 133 A CYS 141 1_555 ? ? ? ? ? ? ? 2.042 ? disulf2 disulf ? ? A CYS 320 SG ? ? ? 1_555 A CYS 338 SG ? ? A CYS 336 A CYS 354 1_555 ? ? ? ? ? ? ? 2.037 ? disulf3 disulf ? ? A CYS 451 SG ? ? ? 1_555 A CYS 596 SG ? ? A CYS 467 A CYS 612 1_555 ? ? ? ? ? ? ? 2.051 ? disulf4 disulf ? ? A CYS 506 SG ? ? ? 1_555 A CYS 524 SG ? ? A CYS 522 A CYS 540 1_555 ? ? ? ? ? ? ? 2.025 ? covale1 covale ? ? A ASN 180 ND2 ? ? ? 1_555 D NAG . C1 ? ? A ASN 196 A NAG 1617 1_555 ? ? ? ? ? ? ? 1.441 ? metalc1 metalc ? ? C ZN . ZN ? ? ? 1_555 A HIS 351 NE2 ? ? A ZN 1616 A HIS 367 1_555 ? ? ? ? ? ? ? 2.455 ? metalc2 metalc ? ? C ZN . ZN ? ? ? 1_555 B ILE 9 O ? ? A ZN 1616 P ILE 9 1_555 ? ? ? ? ? ? ? 2.367 ? metalc3 metalc ? ? C ZN . ZN ? ? ? 1_555 A GLU 379 OE1 ? ? A ZN 1616 A GLU 395 1_555 ? ? ? ? ? ? ? 2.152 ? metalc4 metalc ? ? C ZN . ZN ? ? ? 1_555 A HIS 355 NE2 ? ? A ZN 1616 A HIS 371 1_555 ? ? ? ? ? ? ? 2.178 ? covale2 covale ? ? D NAG . O4 ? ? ? 1_555 E NAG . C1 ? ? A NAG 1617 A NAG 1618 1_555 ? ? ? ? ? ? ? 1.446 ? covale3 covale ? ? E NAG . O4 ? ? ? 1_555 F BMA . C1 ? ? A NAG 1618 A BMA 1619 1_555 ? ? ? ? ? ? ? 1.447 ? covale4 covale ? ? F BMA . O6 ? ? ? 1_555 G MAN . C1 ? ? A BMA 1619 A MAN 1620 1_555 ? ? ? ? ? ? ? 1.441 ? covale5 covale ? ? F BMA . O3 ? ? ? 1_555 H MAN . C1 ? ? A BMA 1619 A MAN 1623 1_555 ? ? ? ? ? ? ? 1.446 ? covale6 covale ? ? I BMA . C1 ? ? ? 1_555 H MAN . O6 ? ? A BMA 1624 A MAN 1623 1_555 ? ? ? ? ? ? ? 1.451 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? metalc ? ? # _struct_mon_prot_cis.pdbx_id 1 _struct_mon_prot_cis.label_comp_id ASP _struct_mon_prot_cis.label_seq_id 130 _struct_mon_prot_cis.label_asym_id A _struct_mon_prot_cis.label_alt_id . _struct_mon_prot_cis.pdbx_PDB_ins_code ? _struct_mon_prot_cis.auth_comp_id ASP _struct_mon_prot_cis.auth_seq_id 146 _struct_mon_prot_cis.auth_asym_id A _struct_mon_prot_cis.pdbx_label_comp_id_2 PRO _struct_mon_prot_cis.pdbx_label_seq_id_2 131 _struct_mon_prot_cis.pdbx_label_asym_id_2 A _struct_mon_prot_cis.pdbx_PDB_ins_code_2 ? _struct_mon_prot_cis.pdbx_auth_comp_id_2 PRO _struct_mon_prot_cis.pdbx_auth_seq_id_2 147 _struct_mon_prot_cis.pdbx_auth_asym_id_2 A _struct_mon_prot_cis.pdbx_PDB_model_num 1 _struct_mon_prot_cis.pdbx_omega_angle 4.86 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details AA ? 2 ? AB ? 2 ? AC ? 2 ? AD ? 2 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense AA 1 2 ? anti-parallel AB 1 2 ? parallel AC 1 2 ? anti-parallel AD 1 2 ? parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id AA 1 LYS A 115 ? VAL A 116 ? LYS A 131 VAL A 132 AA 2 LEU A 127 ? ALA A 128 ? LEU A 143 ALA A 144 AB 1 ILE A 238 ? PRO A 239 ? ILE A 254 PRO A 255 AB 2 ILE A 463 ? GLU A 464 ? ILE A 479 GLU A 480 AC 1 SER A 323 ? ASP A 326 ? SER A 339 ASP A 342 AC 2 VAL A 333 ? LYS A 336 ? VAL A 349 LYS A 352 AD 1 ARG A 469 ? SER A 470 ? ARG A 485 SER A 486 AD 2 CYS A 596 ? VAL A 597 ? CYS A 612 VAL A 613 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id AA 1 2 N VAL A 116 ? N VAL A 132 O LEU A 127 ? O LEU A 143 AB 1 2 O ILE A 238 ? O ILE A 254 N GLU A 464 ? N GLU A 480 AC 1 2 N TRP A 325 ? N TRP A 341 O ARG A 334 ? O ARG A 350 AD 1 2 O ARG A 469 ? O ARG A 485 N VAL A 597 ? N VAL A 613 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE ZN A 1616' AC2 Software ? ? ? ? 19 'BINDING SITE FOR CHAIN A OF SUGAR BOUND TO ASN A 196 RESIDUES 1617 TO 1624' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 6 HIS A 351 ? HIS A 367 . ? 1_555 ? 2 AC1 6 GLU A 352 ? GLU A 368 . ? 1_555 ? 3 AC1 6 HIS A 355 ? HIS A 371 . ? 1_555 ? 4 AC1 6 GLU A 379 ? GLU A 395 . ? 1_555 ? 5 AC1 6 ILE B 9 ? ILE P 9 . ? 1_555 ? 6 AC1 6 PRO B 10 ? PRO P 10 . ? 1_555 ? 7 AC2 19 ASN A 37 ? ASN A 53 . ? 1_555 ? 8 AC2 19 THR A 39 ? THR A 55 . ? 1_555 ? 9 AC2 19 GLU A 41 ? GLU A 57 . ? 1_555 ? 10 AC2 19 ASN A 42 ? ASN A 58 . ? 1_555 ? 11 AC2 19 ARG A 141 ? ARG A 157 . ? 6_555 ? 12 AC2 19 HIS A 143 ? HIS A 159 . ? 6_555 ? 13 AC2 19 ASN A 180 ? ASN A 196 . ? 1_555 ? 14 AC2 19 ARG A 222 ? ARG A 238 . ? 6_555 ? 15 AC2 19 LYS A 225 ? LYS A 241 . ? 6_555 ? 16 AC2 19 HIS A 226 ? HIS A 242 . ? 6_555 ? 17 AC2 19 TYR A 227 ? TYR A 243 . ? 6_555 ? 18 AC2 19 GLY A 228 ? GLY A 244 . ? 6_555 ? 19 AC2 19 PRO A 262 ? PRO A 278 . ? 6_555 ? 20 AC2 19 ASN A 295 ? ASN A 311 . ? 1_555 ? 21 AC2 19 ASP A 314 ? ASP A 330 . ? 1_555 ? 22 AC2 19 ARG A 316 ? ARG A 332 . ? 1_555 ? 23 AC2 19 HOH L . ? HOH A 2203 . ? 6_555 ? 24 AC2 19 HOH L . ? HOH A 2204 . ? 6_555 ? 25 AC2 19 HOH L . ? HOH A 2415 . ? 1_555 ? # _database_PDB_matrix.entry_id 4AA2 _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 4AA2 _atom_sites.fract_transf_matrix[1][1] 0.005773 _atom_sites.fract_transf_matrix[1][2] 0.003333 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.006666 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.009718 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C N O S ZN # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . ALA A 1 1 ? 25.439 32.367 43.948 1.00 55.77 ? 17 ALA A N 1 ATOM 2 C CA . ALA A 1 1 ? 25.884 31.135 44.659 1.00 55.74 ? 17 ALA A CA 1 ATOM 3 C C . ALA A 1 1 ? 25.603 29.872 43.836 1.00 55.69 ? 17 ALA A C 1 ATOM 4 O O . ALA A 1 1 ? 24.693 29.845 42.994 1.00 55.51 ? 17 ALA A O 1 ATOM 5 C CB . ALA A 1 1 ? 25.236 31.046 46.045 1.00 55.77 ? 17 ALA A CB 1 ATOM 6 N N . LEU A 1 2 ? 26.389 28.831 44.104 1.00 55.47 ? 18 LEU A N 1 ATOM 7 C CA . LEU A 1 2 ? 26.392 27.597 43.312 1.00 55.25 ? 18 LEU A CA 1 ATOM 8 C C . LEU A 1 2 ? 25.112 26.766 43.412 1.00 54.98 ? 18 LEU A C 1 ATOM 9 O O . LEU A 1 2 ? 24.719 26.112 42.440 1.00 54.95 ? 18 LEU A O 1 ATOM 10 C CB . LEU A 1 2 ? 27.608 26.739 43.685 1.00 55.30 ? 18 LEU A CB 1 ATOM 11 C CG . LEU A 1 2 ? 28.968 27.278 43.231 1.00 55.48 ? 18 LEU A CG 1 ATOM 12 C CD1 . LEU A 1 2 ? 30.103 26.604 43.986 1.00 55.43 ? 18 LEU A CD1 1 ATOM 13 C CD2 . LEU A 1 2 ? 29.144 27.118 41.724 1.00 55.09 ? 18 LEU A CD2 1 ATOM 14 N N . VAL A 1 3 ? 24.481 26.780 44.586 1.00 54.54 ? 19 VAL A N 1 ATOM 15 C CA . VAL A 1 3 ? 23.254 26.017 44.824 1.00 54.16 ? 19 VAL A CA 1 ATOM 16 C C . VAL A 1 3 ? 22.135 26.462 43.874 1.00 53.67 ? 19 VAL A C 1 ATOM 17 O O . VAL A 1 3 ? 21.484 25.627 43.242 1.00 53.82 ? 19 VAL A O 1 ATOM 18 C CB . VAL A 1 3 ? 22.801 26.099 46.313 1.00 54.30 ? 19 VAL A CB 1 ATOM 19 C CG1 . VAL A 1 3 ? 21.442 25.424 46.520 1.00 54.47 ? 19 VAL A CG1 1 ATOM 20 C CG2 . VAL A 1 3 ? 23.851 25.466 47.227 1.00 54.29 ? 19 VAL A CG2 1 ATOM 21 N N . LYS A 1 4 ? 21.938 27.774 43.762 1.00 53.01 ? 20 LYS A N 1 ATOM 22 C CA . LYS A 1 4 ? 20.931 28.341 42.865 1.00 52.29 ? 20 LYS A CA 1 ATOM 23 C C . LYS A 1 4 ? 21.274 28.097 41.395 1.00 51.66 ? 20 LYS A C 1 ATOM 24 O O . LYS A 1 4 ? 20.380 27.866 40.573 1.00 51.56 ? 20 LYS A O 1 ATOM 25 C CB . LYS A 1 4 ? 20.758 29.843 43.122 1.00 52.34 ? 20 LYS A CB 1 ATOM 26 N N . GLU A 1 5 ? 22.567 28.153 41.072 1.00 50.82 ? 21 GLU A N 1 ATOM 27 C CA . GLU A 1 5 ? 23.023 27.935 39.700 1.00 50.06 ? 21 GLU A CA 1 ATOM 28 C C . GLU A 1 5 ? 22.782 26.500 39.230 1.00 49.39 ? 21 GLU A C 1 ATOM 29 O O . GLU A 1 5 ? 22.380 26.284 38.088 1.00 49.09 ? 21 GLU A O 1 ATOM 30 C CB . GLU A 1 5 ? 24.496 28.322 39.517 1.00 50.05 ? 21 GLU A CB 1 ATOM 31 C CG . GLU A 1 5 ? 24.873 28.491 38.046 1.00 50.35 ? 21 GLU A CG 1 ATOM 32 C CD . GLU A 1 5 ? 26.358 28.643 37.821 1.00 51.12 ? 21 GLU A CD 1 ATOM 33 O OE1 . GLU A 1 5 ? 26.874 29.770 37.982 1.00 51.20 ? 21 GLU A OE1 1 ATOM 34 O OE2 . GLU A 1 5 ? 27.007 27.636 37.460 1.00 51.07 ? 21 GLU A OE2 1 ATOM 35 N N . GLU A 1 6 ? 23.010 25.530 40.116 1.00 48.64 ? 22 GLU A N 1 ATOM 36 C CA . GLU A 1 6 ? 22.836 24.120 39.767 1.00 48.02 ? 22 GLU A CA 1 ATOM 37 C C . GLU A 1 6 ? 21.369 23.773 39.468 1.00 48.00 ? 22 GLU A C 1 ATOM 38 O O . GLU A 1 6 ? 21.084 22.942 38.597 1.00 47.74 ? 22 GLU A O 1 ATOM 39 C CB . GLU A 1 6 ? 23.411 23.211 40.855 1.00 47.74 ? 22 GLU A CB 1 ATOM 40 C CG . GLU A 1 6 ? 23.637 21.781 40.390 1.00 46.69 ? 22 GLU A CG 1 ATOM 41 C CD . GLU A 1 6 ? 24.425 20.935 41.373 1.00 45.12 ? 22 GLU A CD 1 ATOM 42 O OE1 . GLU A 1 6 ? 25.206 21.483 42.177 1.00 44.55 ? 22 GLU A OE1 1 ATOM 43 O OE2 . GLU A 1 6 ? 24.274 19.701 41.327 1.00 44.56 ? 22 GLU A OE2 1 ATOM 44 N N . ILE A 1 7 ? 20.448 24.418 40.184 1.00 47.83 ? 23 ILE A N 1 ATOM 45 C CA . ILE A 1 7 ? 19.012 24.274 39.919 1.00 47.76 ? 23 ILE A CA 1 ATOM 46 C C . ILE A 1 7 ? 18.674 24.829 38.533 1.00 47.68 ? 23 ILE A C 1 ATOM 47 O O . ILE A 1 7 ? 17.920 24.216 37.774 1.00 47.61 ? 23 ILE A O 1 ATOM 48 C CB . ILE A 1 7 ? 18.152 24.955 41.015 1.00 47.76 ? 23 ILE A CB 1 ATOM 49 C CG1 . ILE A 1 7 ? 18.383 24.268 42.368 1.00 47.71 ? 23 ILE A CG1 1 ATOM 50 C CG2 . ILE A 1 7 ? 16.662 24.918 40.641 1.00 47.85 ? 23 ILE A CG2 1 ATOM 51 C CD1 . ILE A 1 7 ? 17.775 24.998 43.560 1.00 48.57 ? 23 ILE A CD1 1 ATOM 52 N N . GLN A 1 8 ? 19.254 25.982 38.215 1.00 47.72 ? 24 GLN A N 1 ATOM 53 C CA . GLN A 1 8 ? 19.088 26.625 36.918 1.00 48.09 ? 24 GLN A CA 1 ATOM 54 C C . GLN A 1 8 ? 19.710 25.786 35.795 1.00 47.72 ? 24 GLN A C 1 ATOM 55 O O . GLN A 1 8 ? 19.165 25.718 34.691 1.00 47.73 ? 24 GLN A O 1 ATOM 56 C CB . GLN A 1 8 ? 19.711 28.024 36.956 1.00 48.35 ? 24 GLN A CB 1 ATOM 57 C CG . GLN A 1 8 ? 19.327 28.948 35.798 1.00 50.70 ? 24 GLN A CG 1 ATOM 58 C CD . GLN A 1 8 ? 19.919 30.350 35.945 1.00 53.63 ? 24 GLN A CD 1 ATOM 59 O OE1 . GLN A 1 8 ? 19.982 30.902 37.050 1.00 54.91 ? 24 GLN A OE1 1 ATOM 60 N NE2 . GLN A 1 8 ? 20.354 30.932 34.827 1.00 54.26 ? 24 GLN A NE2 1 ATOM 61 N N . ALA A 1 9 ? 20.846 25.155 36.094 1.00 47.34 ? 25 ALA A N 1 ATOM 62 C CA . ALA A 1 9 ? 21.585 24.332 35.129 1.00 46.97 ? 25 ALA A CA 1 ATOM 63 C C . ALA A 1 9 ? 20.802 23.090 34.716 1.00 46.74 ? 25 ALA A C 1 ATOM 64 O O . ALA A 1 9 ? 20.786 22.730 33.539 1.00 46.51 ? 25 ALA A O 1 ATOM 65 C CB . ALA A 1 9 ? 22.938 23.938 35.697 1.00 46.88 ? 25 ALA A CB 1 ATOM 66 N N . LYS A 1 10 ? 20.162 22.446 35.694 1.00 46.57 ? 26 LYS A N 1 ATOM 67 C CA . LYS A 1 10 ? 19.304 21.282 35.458 1.00 46.65 ? 26 LYS A CA 1 ATOM 68 C C . LYS A 1 10 ? 18.178 21.613 34.473 1.00 46.51 ? 26 LYS A C 1 ATOM 69 O O . LYS A 1 10 ? 17.840 20.808 33.599 1.00 46.27 ? 26 LYS A O 1 ATOM 70 C CB . LYS A 1 10 ? 18.727 20.782 36.785 1.00 46.80 ? 26 LYS A CB 1 ATOM 71 C CG . LYS A 1 10 ? 17.865 19.533 36.677 1.00 47.96 ? 26 LYS A CG 1 ATOM 72 C CD . LYS A 1 10 ? 17.508 19.010 38.054 1.00 50.26 ? 26 LYS A CD 1 ATOM 73 C CE . LYS A 1 10 ? 16.622 17.788 37.958 1.00 51.72 ? 26 LYS A CE 1 ATOM 74 N NZ . LYS A 1 10 ? 16.501 17.130 39.283 1.00 53.26 ? 26 LYS A NZ 1 ATOM 75 N N . GLU A 1 11 ? 17.621 22.813 34.626 1.00 46.25 ? 27 GLU A N 1 ATOM 76 C CA . GLU A 1 11 ? 16.568 23.331 33.763 1.00 46.07 ? 27 GLU A CA 1 ATOM 77 C C . GLU A 1 11 ? 17.108 23.643 32.366 1.00 45.34 ? 27 GLU A C 1 ATOM 78 O O . GLU A 1 11 ? 16.444 23.374 31.362 1.00 45.03 ? 27 GLU A O 1 ATOM 79 C CB . GLU A 1 11 ? 15.986 24.597 34.391 1.00 46.39 ? 27 GLU A CB 1 ATOM 80 C CG . GLU A 1 11 ? 14.531 24.869 34.075 1.00 48.33 ? 27 GLU A CG 1 ATOM 81 C CD . GLU A 1 11 ? 13.977 26.003 34.927 1.00 51.08 ? 27 GLU A CD 1 ATOM 82 O OE1 . GLU A 1 11 ? 13.867 25.827 36.165 1.00 51.77 ? 27 GLU A OE1 1 ATOM 83 O OE2 . GLU A 1 11 ? 13.681 27.079 34.360 1.00 52.09 ? 27 GLU A OE2 1 ATOM 84 N N . TYR A 1 12 ? 18.310 24.217 32.321 1.00 44.60 ? 28 TYR A N 1 ATOM 85 C CA . TYR A 1 12 ? 19.000 24.515 31.070 1.00 44.15 ? 28 TYR A CA 1 ATOM 86 C C . TYR A 1 12 ? 19.258 23.245 30.261 1.00 43.95 ? 28 TYR A C 1 ATOM 87 O O . TYR A 1 12 ? 18.997 23.212 29.058 1.00 43.79 ? 28 TYR A O 1 ATOM 88 C CB . TYR A 1 12 ? 20.314 25.257 31.349 1.00 44.06 ? 28 TYR A CB 1 ATOM 89 C CG . TYR A 1 12 ? 21.227 25.422 30.148 1.00 43.79 ? 28 TYR A CG 1 ATOM 90 C CD1 . TYR A 1 12 ? 21.033 26.458 29.232 1.00 43.93 ? 28 TYR A CD1 1 ATOM 91 C CD2 . TYR A 1 12 ? 22.293 24.549 29.936 1.00 43.72 ? 28 TYR A CD2 1 ATOM 92 C CE1 . TYR A 1 12 ? 21.877 26.615 28.131 1.00 44.23 ? 28 TYR A CE1 1 ATOM 93 C CE2 . TYR A 1 12 ? 23.137 24.697 28.843 1.00 44.05 ? 28 TYR A CE2 1 ATOM 94 C CZ . TYR A 1 12 ? 22.924 25.728 27.945 1.00 44.35 ? 28 TYR A CZ 1 ATOM 95 O OH . TYR A 1 12 ? 23.764 25.870 26.861 1.00 44.97 ? 28 TYR A OH 1 ATOM 96 N N . LEU A 1 13 ? 19.765 22.208 30.928 1.00 43.69 ? 29 LEU A N 1 ATOM 97 C CA . LEU A 1 13 ? 20.075 20.936 30.267 1.00 43.69 ? 29 LEU A CA 1 ATOM 98 C C . LEU A 1 13 ? 18.830 20.282 29.679 1.00 43.92 ? 29 LEU A C 1 ATOM 99 O O . LEU A 1 13 ? 18.851 19.812 28.537 1.00 43.80 ? 29 LEU A O 1 ATOM 100 C CB . LEU A 1 13 ? 20.773 19.969 31.228 1.00 43.40 ? 29 LEU A CB 1 ATOM 101 C CG . LEU A 1 13 ? 22.222 20.285 31.619 1.00 42.91 ? 29 LEU A CG 1 ATOM 102 C CD1 . LEU A 1 13 ? 22.678 19.350 32.715 1.00 41.94 ? 29 LEU A CD1 1 ATOM 103 C CD2 . LEU A 1 13 ? 23.160 20.207 30.416 1.00 42.50 ? 29 LEU A CD2 1 ATOM 104 N N . GLU A 1 14 ? 17.755 20.273 30.466 1.00 44.14 ? 30 GLU A N 1 ATOM 105 C CA . GLU A 1 14 ? 16.484 19.669 30.078 1.00 44.75 ? 30 GLU A CA 1 ATOM 106 C C . GLU A 1 14 ? 15.963 20.290 28.779 1.00 44.40 ? 30 GLU A C 1 ATOM 107 O O . GLU A 1 14 ? 15.545 19.570 27.868 1.00 44.56 ? 30 GLU A O 1 ATOM 108 C CB . GLU A 1 14 ? 15.465 19.818 31.212 1.00 44.99 ? 30 GLU A CB 1 ATOM 109 C CG . GLU A 1 14 ? 14.628 18.567 31.494 1.00 47.73 ? 30 GLU A CG 1 ATOM 110 C CD . GLU A 1 14 ? 13.432 18.407 30.558 1.00 51.19 ? 30 GLU A CD 1 ATOM 111 O OE1 . GLU A 1 14 ? 12.885 19.434 30.091 1.00 52.83 ? 30 GLU A OE1 1 ATOM 112 O OE2 . GLU A 1 14 ? 13.032 17.248 30.294 1.00 52.30 ? 30 GLU A OE2 1 ATOM 113 N N . ASN A 1 15 ? 16.029 21.618 28.695 1.00 44.18 ? 31 ASN A N 1 ATOM 114 C CA A ASN A 1 15 ? 15.592 22.346 27.506 0.50 44.08 ? 31 ASN A CA 1 ATOM 115 C CA B ASN A 1 15 ? 15.594 22.354 27.507 0.50 44.25 ? 31 ASN A CA 1 ATOM 116 C C . ASN A 1 15 ? 16.533 22.158 26.316 1.00 44.06 ? 31 ASN A C 1 ATOM 117 O O . ASN A 1 15 ? 16.081 21.973 25.185 1.00 44.18 ? 31 ASN A O 1 ATOM 118 C CB A ASN A 1 15 ? 15.419 23.835 27.823 0.50 44.01 ? 31 ASN A CB 1 ATOM 119 C CB B ASN A 1 15 ? 15.452 23.848 27.824 0.50 44.32 ? 31 ASN A CB 1 ATOM 120 C CG A ASN A 1 15 ? 14.328 24.089 28.845 0.50 43.97 ? 31 ASN A CG 1 ATOM 121 C CG B ASN A 1 15 ? 14.849 24.637 26.674 0.50 44.98 ? 31 ASN A CG 1 ATOM 122 O OD1 A ASN A 1 15 ? 13.420 23.274 29.013 0.50 44.01 ? 31 ASN A OD1 1 ATOM 123 O OD1 B ASN A 1 15 ? 13.654 24.533 26.392 0.50 45.76 ? 31 ASN A OD1 1 ATOM 124 N ND2 A ASN A 1 15 ? 14.410 25.220 29.534 0.50 43.67 ? 31 ASN A ND2 1 ATOM 125 N ND2 B ASN A 1 15 ? 15.675 25.435 26.006 0.50 45.47 ? 31 ASN A ND2 1 ATOM 126 N N . LEU A 1 16 ? 17.838 22.202 26.578 1.00 43.75 ? 32 LEU A N 1 ATOM 127 C CA . LEU A 1 16 ? 18.849 22.073 25.526 1.00 43.49 ? 32 LEU A CA 1 ATOM 128 C C . LEU A 1 16 ? 18.873 20.681 24.891 1.00 43.24 ? 32 LEU A C 1 ATOM 129 O O . LEU A 1 16 ? 18.983 20.554 23.664 1.00 42.92 ? 32 LEU A O 1 ATOM 130 C CB . LEU A 1 16 ? 20.240 22.435 26.060 1.00 43.41 ? 32 LEU A CB 1 ATOM 131 C CG . LEU A 1 16 ? 21.397 22.457 25.057 1.00 43.76 ? 32 LEU A CG 1 ATOM 132 C CD1 . LEU A 1 16 ? 21.165 23.481 23.943 1.00 43.37 ? 32 LEU A CD1 1 ATOM 133 C CD2 . LEU A 1 16 ? 22.705 22.738 25.778 1.00 43.87 ? 32 LEU A CD2 1 ATOM 134 N N . ASN A 1 17 ? 18.781 19.650 25.728 1.00 42.75 ? 33 ASN A N 1 ATOM 135 C CA . ASN A 1 17 ? 18.713 18.277 25.248 1.00 42.95 ? 33 ASN A CA 1 ATOM 136 C C . ASN A 1 17 ? 17.583 18.090 24.239 1.00 42.99 ? 33 ASN A C 1 ATOM 137 O O . ASN A 1 17 ? 17.807 17.571 23.147 1.00 42.90 ? 33 ASN A O 1 ATOM 138 C CB . ASN A 1 17 ? 18.582 17.285 26.411 1.00 42.74 ? 33 ASN A CB 1 ATOM 139 C CG . ASN A 1 17 ? 19.933 16.874 26.989 1.00 42.96 ? 33 ASN A CG 1 ATOM 140 O OD1 . ASN A 1 17 ? 20.816 16.407 26.268 1.00 42.03 ? 33 ASN A OD1 1 ATOM 141 N ND2 . ASN A 1 17 ? 20.093 17.037 28.300 1.00 42.83 ? 33 ASN A ND2 1 ATOM 142 N N . LYS A 1 18 ? 16.383 18.546 24.599 1.00 43.12 ? 34 LYS A N 1 ATOM 143 C CA . LYS A 1 18 ? 15.215 18.435 23.718 1.00 43.13 ? 34 LYS A CA 1 ATOM 144 C C . LYS A 1 18 ? 15.429 19.186 22.405 1.00 42.81 ? 34 LYS A C 1 ATOM 145 O O . LYS A 1 18 ? 15.076 18.688 21.332 1.00 43.21 ? 34 LYS A O 1 ATOM 146 C CB . LYS A 1 18 ? 13.940 18.909 24.427 1.00 43.48 ? 34 LYS A CB 1 ATOM 147 C CG . LYS A 1 18 ? 13.505 17.996 25.583 1.00 44.67 ? 34 LYS A CG 1 ATOM 148 C CD . LYS A 1 18 ? 12.131 18.352 26.151 1.00 46.84 ? 34 LYS A CD 1 ATOM 149 C CE . LYS A 1 18 ? 12.155 19.659 26.943 1.00 48.24 ? 34 LYS A CE 1 ATOM 150 N NZ . LYS A 1 18 ? 10.973 19.785 27.859 1.00 49.03 ? 34 LYS A NZ 1 ATOM 151 N N . GLU A 1 19 ? 16.026 20.371 22.493 1.00 42.29 ? 35 GLU A N 1 ATOM 152 C CA . GLU A 1 19 ? 16.350 21.167 21.314 1.00 41.75 ? 35 GLU A CA 1 ATOM 153 C C . GLU A 1 19 ? 17.378 20.469 20.408 1.00 41.63 ? 35 GLU A C 1 ATOM 154 O O . GLU A 1 19 ? 17.253 20.498 19.172 1.00 41.17 ? 35 GLU A O 1 ATOM 155 C CB . GLU A 1 19 ? 16.830 22.565 21.730 1.00 41.78 ? 35 GLU A CB 1 ATOM 156 C CG . GLU A 1 19 ? 17.500 23.351 20.618 1.00 41.82 ? 35 GLU A CG 1 ATOM 157 C CD . GLU A 1 19 ? 17.354 24.850 20.758 1.00 42.23 ? 35 GLU A CD 1 ATOM 158 O OE1 . GLU A 1 19 ? 17.178 25.346 21.894 1.00 42.34 ? 35 GLU A OE1 1 ATOM 159 O OE2 . GLU A 1 19 ? 17.420 25.533 19.714 1.00 42.32 ? 35 GLU A OE2 1 ATOM 160 N N . LEU A 1 20 ? 18.385 19.848 21.024 1.00 41.09 ? 36 LEU A N 1 ATOM 161 C CA . LEU A 1 20 ? 19.417 19.125 20.281 1.00 40.99 ? 36 LEU A CA 1 ATOM 162 C C . LEU A 1 20 ? 18.855 17.911 19.543 1.00 40.80 ? 36 LEU A C 1 ATOM 163 O O . LEU A 1 20 ? 19.241 17.639 18.408 1.00 40.57 ? 36 LEU A O 1 ATOM 164 C CB . LEU A 1 20 ? 20.570 18.704 21.199 1.00 41.01 ? 36 LEU A CB 1 ATOM 165 C CG . LEU A 1 20 ? 21.520 19.810 21.674 1.00 41.56 ? 36 LEU A CG 1 ATOM 166 C CD1 . LEU A 1 20 ? 22.452 19.295 22.768 1.00 41.21 ? 36 LEU A CD1 1 ATOM 167 C CD2 . LEU A 1 20 ? 22.313 20.376 20.510 1.00 41.94 ? 36 LEU A CD2 1 ATOM 168 N N . ALA A 1 21 ? 17.948 17.189 20.197 1.00 40.59 ? 37 ALA A N 1 ATOM 169 C CA . ALA A 1 21 ? 17.267 16.056 19.578 1.00 40.55 ? 37 ALA A CA 1 ATOM 170 C C . ALA A 1 21 ? 16.525 16.488 18.311 1.00 40.56 ? 37 ALA A C 1 ATOM 171 O O . ALA A 1 21 ? 16.686 15.878 17.249 1.00 40.32 ? 37 ALA A O 1 ATOM 172 C CB . ALA A 1 21 ? 16.314 15.404 20.569 1.00 40.65 ? 37 ALA A CB 1 ATOM 173 N N . LYS A 1 22 ? 15.746 17.563 18.428 1.00 40.61 ? 38 LYS A N 1 ATOM 174 C CA . LYS A 1 22 ? 14.949 18.084 17.320 1.00 40.65 ? 38 LYS A CA 1 ATOM 175 C C . LYS A 1 22 ? 15.814 18.555 16.150 1.00 40.57 ? 38 LYS A C 1 ATOM 176 O O . LYS A 1 22 ? 15.486 18.311 14.985 1.00 40.37 ? 38 LYS A O 1 ATOM 177 C CB . LYS A 1 22 ? 14.039 19.213 17.816 1.00 40.84 ? 38 LYS A CB 1 ATOM 178 C CG . LYS A 1 22 ? 12.954 19.645 16.840 1.00 41.24 ? 38 LYS A CG 1 ATOM 179 C CD . LYS A 1 22 ? 11.948 18.534 16.553 1.00 41.48 ? 38 LYS A CD 1 ATOM 180 C CE . LYS A 1 22 ? 10.649 19.126 16.022 1.00 41.37 ? 38 LYS A CE 1 ATOM 181 N NZ . LYS A 1 22 ? 9.822 18.131 15.313 1.00 40.87 ? 38 LYS A NZ 1 ATOM 182 N N . ARG A 1 23 ? 16.915 19.232 16.469 1.00 40.53 ? 39 ARG A N 1 ATOM 183 C CA . ARG A 1 23 ? 17.861 19.693 15.456 1.00 40.54 ? 39 ARG A CA 1 ATOM 184 C C . ARG A 1 23 ? 18.611 18.530 14.797 1.00 40.40 ? 39 ARG A C 1 ATOM 185 O O . ARG A 1 23 ? 18.846 18.550 13.586 1.00 40.43 ? 39 ARG A O 1 ATOM 186 C CB . ARG A 1 23 ? 18.854 20.692 16.056 1.00 40.62 ? 39 ARG A CB 1 ATOM 187 C CG . ARG A 1 23 ? 18.256 22.047 16.394 1.00 40.67 ? 39 ARG A CG 1 ATOM 188 C CD . ARG A 1 23 ? 19.282 22.934 17.065 1.00 41.37 ? 39 ARG A CD 1 ATOM 189 N NE . ARG A 1 23 ? 18.720 24.226 17.449 1.00 41.37 ? 39 ARG A NE 1 ATOM 190 C CZ . ARG A 1 23 ? 18.786 25.328 16.707 1.00 41.07 ? 39 ARG A CZ 1 ATOM 191 N NH1 . ARG A 1 23 ? 19.394 25.315 15.523 1.00 39.52 ? 39 ARG A NH1 1 ATOM 192 N NH2 . ARG A 1 23 ? 18.241 26.451 17.157 1.00 40.54 ? 39 ARG A NH2 1 ATOM 193 N N . THR A 1 24 ? 18.975 17.523 15.588 1.00 40.25 ? 40 THR A N 1 ATOM 194 C CA . THR A 1 24 ? 19.681 16.348 15.059 1.00 40.52 ? 40 THR A CA 1 ATOM 195 C C . THR A 1 24 ? 18.777 15.521 14.133 1.00 40.61 ? 40 THR A C 1 ATOM 196 O O . THR A 1 24 ? 19.241 15.013 13.110 1.00 40.73 ? 40 THR A O 1 ATOM 197 C CB . THR A 1 24 ? 20.283 15.462 16.177 1.00 40.59 ? 40 THR A CB 1 ATOM 198 O OG1 . THR A 1 24 ? 21.053 16.276 17.073 1.00 40.36 ? 40 THR A OG1 1 ATOM 199 C CG2 . THR A 1 24 ? 21.196 14.384 15.583 1.00 40.56 ? 40 THR A CG2 1 ATOM 200 N N . ASN A 1 25 ? 17.498 15.410 14.495 1.00 40.49 ? 41 ASN A N 1 ATOM 201 C CA . ASN A 1 25 ? 16.475 14.802 13.638 1.00 40.49 ? 41 ASN A CA 1 ATOM 202 C C . ASN A 1 25 ? 16.491 15.371 12.214 1.00 40.65 ? 41 ASN A C 1 ATOM 203 O O . ASN A 1 25 ? 16.421 14.619 11.239 1.00 40.69 ? 41 ASN A O 1 ATOM 204 C CB . ASN A 1 25 ? 15.083 14.976 14.263 1.00 40.47 ? 41 ASN A CB 1 ATOM 205 C CG . ASN A 1 25 ? 13.957 14.544 13.325 1.00 40.44 ? 41 ASN A CG 1 ATOM 206 O OD1 . ASN A 1 25 ? 13.389 15.366 12.600 1.00 39.86 ? 41 ASN A OD1 1 ATOM 207 N ND2 . ASN A 1 25 ? 13.648 13.253 13.322 1.00 38.98 ? 41 ASN A ND2 1 ATOM 208 N N . VAL A 1 26 ? 16.591 16.696 12.112 1.00 40.65 ? 42 VAL A N 1 ATOM 209 C CA . VAL A 1 26 ? 16.609 17.393 10.828 1.00 40.72 ? 42 VAL A CA 1 ATOM 210 C C . VAL A 1 26 ? 17.873 17.052 10.035 1.00 40.62 ? 42 VAL A C 1 ATOM 211 O O . VAL A 1 26 ? 17.809 16.814 8.825 1.00 40.58 ? 42 VAL A O 1 ATOM 212 C CB . VAL A 1 26 ? 16.460 18.934 11.016 1.00 40.94 ? 42 VAL A CB 1 ATOM 213 C CG1 . VAL A 1 26 ? 16.656 19.679 9.693 1.00 41.08 ? 42 VAL A CG1 1 ATOM 214 C CG2 . VAL A 1 26 ? 15.102 19.268 11.625 1.00 40.79 ? 42 VAL A CG2 1 ATOM 215 N N . GLU A 1 27 ? 19.015 17.027 10.720 1.00 40.45 ? 43 GLU A N 1 ATOM 216 C CA . GLU A 1 27 ? 20.278 16.619 10.103 1.00 40.44 ? 43 GLU A CA 1 ATOM 217 C C . GLU A 1 27 ? 20.231 15.153 9.669 1.00 39.92 ? 43 GLU A C 1 ATOM 218 O O . GLU A 1 27 ? 20.695 14.806 8.580 1.00 39.65 ? 43 GLU A O 1 ATOM 219 C CB . GLU A 1 27 ? 21.452 16.845 11.065 1.00 40.85 ? 43 GLU A CB 1 ATOM 220 C CG . GLU A 1 27 ? 22.827 16.550 10.460 1.00 42.02 ? 43 GLU A CG 1 ATOM 221 C CD . GLU A 1 27 ? 23.917 16.357 11.512 1.00 44.63 ? 43 GLU A CD 1 ATOM 222 O OE1 . GLU A 1 27 ? 23.615 15.826 12.608 1.00 45.28 ? 43 GLU A OE1 1 ATOM 223 O OE2 . GLU A 1 27 ? 25.079 16.735 11.239 1.00 44.88 ? 43 GLU A OE2 1 ATOM 224 N N . THR A 1 28 ? 19.666 14.306 10.528 1.00 39.45 ? 44 THR A N 1 ATOM 225 C CA . THR A 1 28 ? 19.592 12.872 10.278 1.00 39.42 ? 44 THR A CA 1 ATOM 226 C C . THR A 1 28 ? 18.708 12.553 9.064 1.00 39.27 ? 44 THR A C 1 ATOM 227 O O . THR A 1 28 ? 19.054 11.685 8.259 1.00 38.97 ? 44 THR A O 1 ATOM 228 C CB . THR A 1 28 ? 19.124 12.101 11.525 1.00 39.50 ? 44 THR A CB 1 ATOM 229 O OG1 . THR A 1 28 ? 19.941 12.469 12.642 1.00 40.13 ? 44 THR A OG1 1 ATOM 230 C CG2 . THR A 1 28 ? 19.255 10.601 11.313 1.00 40.10 ? 44 THR A CG2 1 ATOM 231 N N . GLU A 1 29 ? 17.591 13.271 8.928 1.00 39.17 ? 45 GLU A N 1 ATOM 232 C CA . GLU A 1 29 ? 16.700 13.114 7.774 1.00 39.25 ? 45 GLU A CA 1 ATOM 233 C C . GLU A 1 29 ? 17.412 13.400 6.457 1.00 39.04 ? 45 GLU A C 1 ATOM 234 O O . GLU A 1 29 ? 17.260 12.648 5.495 1.00 38.94 ? 45 GLU A O 1 ATOM 235 C CB . GLU A 1 29 ? 15.452 13.997 7.903 1.00 39.37 ? 45 GLU A CB 1 ATOM 236 C CG . GLU A 1 29 ? 14.372 13.431 8.816 1.00 40.17 ? 45 GLU A CG 1 ATOM 237 C CD . GLU A 1 29 ? 13.662 12.207 8.240 1.00 41.61 ? 45 GLU A CD 1 ATOM 238 O OE1 . GLU A 1 29 ? 13.937 11.817 7.081 1.00 42.13 ? 45 GLU A OE1 1 ATOM 239 O OE2 . GLU A 1 29 ? 12.814 11.637 8.957 1.00 42.38 ? 45 GLU A OE2 1 ATOM 240 N N . ALA A 1 30 ? 18.194 14.481 6.425 1.00 38.92 ? 46 ALA A N 1 ATOM 241 C CA . ALA A 1 30 ? 18.954 14.847 5.226 1.00 38.86 ? 46 ALA A CA 1 ATOM 242 C C . ALA A 1 30 ? 20.039 13.818 4.902 1.00 38.63 ? 46 ALA A C 1 ATOM 243 O O . ALA A 1 30 ? 20.315 13.551 3.731 1.00 38.24 ? 46 ALA A O 1 ATOM 244 C CB . ALA A 1 30 ? 19.562 16.240 5.376 1.00 38.89 ? 46 ALA A CB 1 ATOM 245 N N . ALA A 1 31 ? 20.648 13.254 5.946 1.00 38.46 ? 47 ALA A N 1 ATOM 246 C CA . ALA A 1 31 ? 21.677 12.223 5.792 1.00 38.53 ? 47 ALA A CA 1 ATOM 247 C C . ALA A 1 31 ? 21.061 10.935 5.245 1.00 38.58 ? 47 ALA A C 1 ATOM 248 O O . ALA A 1 31 ? 21.615 10.309 4.335 1.00 38.43 ? 47 ALA A O 1 ATOM 249 C CB . ALA A 1 31 ? 22.388 11.966 7.125 1.00 38.36 ? 47 ALA A CB 1 ATOM 250 N N . TRP A 1 32 ? 19.909 10.565 5.803 1.00 38.82 ? 48 TRP A N 1 ATOM 251 C CA . TRP A 1 32 ? 19.141 9.402 5.368 1.00 39.22 ? 48 TRP A CA 1 ATOM 252 C C . TRP A 1 32 ? 18.788 9.510 3.883 1.00 39.71 ? 48 TRP A C 1 ATOM 253 O O . TRP A 1 32 ? 18.977 8.558 3.129 1.00 39.62 ? 48 TRP A O 1 ATOM 254 C CB . TRP A 1 32 ? 17.875 9.242 6.219 1.00 39.11 ? 48 TRP A CB 1 ATOM 255 C CG . TRP A 1 32 ? 16.852 8.311 5.612 1.00 39.08 ? 48 TRP A CG 1 ATOM 256 C CD1 . TRP A 1 32 ? 15.828 8.655 4.768 1.00 39.16 ? 48 TRP A CD1 1 ATOM 257 C CD2 . TRP A 1 32 ? 16.769 6.891 5.785 1.00 38.48 ? 48 TRP A CD2 1 ATOM 258 N NE1 . TRP A 1 32 ? 15.112 7.536 4.410 1.00 39.51 ? 48 TRP A NE1 1 ATOM 259 C CE2 . TRP A 1 32 ? 15.666 6.440 5.018 1.00 38.80 ? 48 TRP A CE2 1 ATOM 260 C CE3 . TRP A 1 32 ? 17.517 5.953 6.511 1.00 38.06 ? 48 TRP A CE3 1 ATOM 261 C CZ2 . TRP A 1 32 ? 15.290 5.092 4.961 1.00 38.26 ? 48 TRP A CZ2 1 ATOM 262 C CZ3 . TRP A 1 32 ? 17.138 4.606 6.459 1.00 37.65 ? 48 TRP A CZ3 1 ATOM 263 C CH2 . TRP A 1 32 ? 16.036 4.192 5.687 1.00 38.48 ? 48 TRP A CH2 1 ATOM 264 N N . ALA A 1 33 ? 18.288 10.680 3.483 1.00 40.20 ? 49 ALA A N 1 ATOM 265 C CA . ALA A 1 33 ? 17.903 10.948 2.098 1.00 40.57 ? 49 ALA A CA 1 ATOM 266 C C . ALA A 1 33 ? 19.075 10.760 1.144 1.00 40.87 ? 49 ALA A C 1 ATOM 267 O O . ALA A 1 33 ? 18.914 10.209 0.051 1.00 41.05 ? 49 ALA A O 1 ATOM 268 C CB . ALA A 1 33 ? 17.336 12.356 1.969 1.00 40.43 ? 49 ALA A CB 1 ATOM 269 N N . TYR A 1 34 ? 20.252 11.211 1.566 1.00 41.08 ? 50 TYR A N 1 ATOM 270 C CA . TYR A 1 34 ? 21.445 11.124 0.739 1.00 41.43 ? 50 TYR A CA 1 ATOM 271 C C . TYR A 1 34 ? 21.928 9.684 0.571 1.00 41.58 ? 50 TYR A C 1 ATOM 272 O O . TYR A 1 34 ? 22.238 9.248 -0.552 1.00 41.16 ? 50 TYR A O 1 ATOM 273 C CB . TYR A 1 34 ? 22.566 11.996 1.308 1.00 41.61 ? 50 TYR A CB 1 ATOM 274 C CG . TYR A 1 34 ? 23.864 11.858 0.553 1.00 42.21 ? 50 TYR A CG 1 ATOM 275 C CD1 . TYR A 1 34 ? 23.956 12.248 -0.784 1.00 43.45 ? 50 TYR A CD1 1 ATOM 276 C CD2 . TYR A 1 34 ? 24.996 11.331 1.166 1.00 43.20 ? 50 TYR A CD2 1 ATOM 277 C CE1 . TYR A 1 34 ? 25.145 12.123 -1.492 1.00 44.09 ? 50 TYR A CE1 1 ATOM 278 C CE2 . TYR A 1 34 ? 26.194 11.203 0.468 1.00 44.39 ? 50 TYR A CE2 1 ATOM 279 C CZ . TYR A 1 34 ? 26.260 11.601 -0.862 1.00 44.65 ? 50 TYR A CZ 1 ATOM 280 O OH . TYR A 1 34 ? 27.438 11.480 -1.563 1.00 45.74 ? 50 TYR A OH 1 ATOM 281 N N . GLY A 1 35 ? 21.991 8.961 1.689 1.00 41.55 ? 51 GLY A N 1 ATOM 282 C CA . GLY A 1 35 ? 22.406 7.562 1.704 1.00 41.97 ? 51 GLY A CA 1 ATOM 283 C C . GLY A 1 35 ? 21.446 6.652 0.960 1.00 42.33 ? 51 GLY A C 1 ATOM 284 O O . GLY A 1 35 ? 21.858 5.625 0.420 1.00 42.27 ? 51 GLY A O 1 ATOM 285 N N . SER A 1 36 ? 20.168 7.031 0.940 1.00 42.81 ? 52 SER A N 1 ATOM 286 C CA . SER A 1 36 ? 19.127 6.282 0.231 1.00 43.59 ? 52 SER A CA 1 ATOM 287 C C . SER A 1 36 ? 19.079 6.611 -1.255 1.00 43.97 ? 52 SER A C 1 ATOM 288 O O . SER A 1 36 ? 18.486 5.867 -2.029 1.00 44.21 ? 52 SER A O 1 ATOM 289 C CB . SER A 1 36 ? 17.749 6.577 0.827 1.00 43.43 ? 52 SER A CB 1 ATOM 290 O OG . SER A 1 36 ? 17.693 6.237 2.197 1.00 44.72 ? 52 SER A OG 1 ATOM 291 N N . ASN A 1 37 ? 19.693 7.729 -1.642 1.00 44.76 ? 53 ASN A N 1 ATOM 292 C CA . ASN A 1 37 ? 19.554 8.289 -2.989 1.00 45.64 ? 53 ASN A CA 1 ATOM 293 C C . ASN A 1 37 ? 20.656 9.323 -3.249 1.00 45.73 ? 53 ASN A C 1 ATOM 294 O O . ASN A 1 37 ? 20.474 10.520 -3.020 1.00 45.79 ? 53 ASN A O 1 ATOM 295 C CB . ASN A 1 37 ? 18.144 8.900 -3.144 1.00 45.99 ? 53 ASN A CB 1 ATOM 296 C CG . ASN A 1 37 ? 17.882 9.493 -4.528 1.00 47.82 ? 53 ASN A CG 1 ATOM 297 O OD1 . ASN A 1 37 ? 18.489 9.099 -5.530 1.00 47.18 ? 53 ASN A OD1 1 ATOM 298 N ND2 . ASN A 1 37 ? 16.953 10.454 -4.577 1.00 51.34 ? 53 ASN A ND2 1 ATOM 299 N N . ILE A 1 38 ? 21.807 8.845 -3.716 1.00 46.05 ? 54 ILE A N 1 ATOM 300 C CA . ILE A 1 38 ? 22.985 9.690 -3.888 1.00 46.69 ? 54 ILE A CA 1 ATOM 301 C C . ILE A 1 38 ? 22.884 10.574 -5.131 1.00 47.27 ? 54 ILE A C 1 ATOM 302 O O . ILE A 1 38 ? 22.893 10.083 -6.261 1.00 47.41 ? 54 ILE A O 1 ATOM 303 C CB . ILE A 1 38 ? 24.295 8.851 -3.919 1.00 46.79 ? 54 ILE A CB 1 ATOM 304 C CG1 . ILE A 1 38 ? 24.525 8.176 -2.562 1.00 46.63 ? 54 ILE A CG1 1 ATOM 305 C CG2 . ILE A 1 38 ? 25.499 9.721 -4.316 1.00 46.67 ? 54 ILE A CG2 1 ATOM 306 C CD1 . ILE A 1 38 ? 25.616 7.143 -2.565 1.00 47.24 ? 54 ILE A CD1 1 ATOM 307 N N . THR A 1 39 ? 22.774 11.879 -4.895 1.00 47.88 ? 55 THR A N 1 ATOM 308 C CA . THR A 1 39 ? 22.769 12.893 -5.951 1.00 48.44 ? 55 THR A CA 1 ATOM 309 C C . THR A 1 39 ? 23.528 14.125 -5.457 1.00 48.95 ? 55 THR A C 1 ATOM 310 O O . THR A 1 39 ? 23.721 14.295 -4.247 1.00 48.75 ? 55 THR A O 1 ATOM 311 C CB . THR A 1 39 ? 21.328 13.324 -6.353 1.00 48.42 ? 55 THR A CB 1 ATOM 312 O OG1 . THR A 1 39 ? 20.604 13.755 -5.191 1.00 48.15 ? 55 THR A OG1 1 ATOM 313 C CG2 . THR A 1 39 ? 20.569 12.185 -7.034 1.00 48.31 ? 55 THR A CG2 1 ATOM 314 N N . ASP A 1 40 ? 23.958 14.975 -6.390 1.00 49.47 ? 56 ASP A N 1 ATOM 315 C CA . ASP A 1 40 ? 24.606 16.243 -6.047 1.00 50.07 ? 56 ASP A CA 1 ATOM 316 C C . ASP A 1 40 ? 23.708 17.131 -5.188 1.00 50.22 ? 56 ASP A C 1 ATOM 317 O O . ASP A 1 40 ? 24.183 17.786 -4.257 1.00 50.25 ? 56 ASP A O 1 ATOM 318 C CB . ASP A 1 40 ? 25.047 16.990 -7.310 1.00 50.28 ? 56 ASP A CB 1 ATOM 319 C CG . ASP A 1 40 ? 26.273 16.371 -7.960 1.00 51.26 ? 56 ASP A CG 1 ATOM 320 O OD1 . ASP A 1 40 ? 26.817 15.384 -7.416 1.00 51.88 ? 56 ASP A OD1 1 ATOM 321 O OD2 . ASP A 1 40 ? 26.703 16.875 -9.020 1.00 52.65 ? 56 ASP A OD2 1 ATOM 322 N N . GLU A 1 41 ? 22.412 17.129 -5.498 1.00 50.57 ? 57 GLU A N 1 ATOM 323 C CA . GLU A 1 41 ? 21.418 17.915 -4.764 1.00 50.97 ? 57 GLU A CA 1 ATOM 324 C C . GLU A 1 41 ? 21.294 17.462 -3.308 1.00 50.75 ? 57 GLU A C 1 ATOM 325 O O . GLU A 1 41 ? 21.292 18.288 -2.395 1.00 50.70 ? 57 GLU A O 1 ATOM 326 C CB . GLU A 1 41 ? 20.055 17.839 -5.464 1.00 51.30 ? 57 GLU A CB 1 ATOM 327 C CG . GLU A 1 41 ? 18.957 18.705 -4.845 1.00 53.08 ? 57 GLU A CG 1 ATOM 328 C CD . GLU A 1 41 ? 17.576 18.455 -5.455 1.00 55.67 ? 57 GLU A CD 1 ATOM 329 O OE1 . GLU A 1 41 ? 17.456 18.422 -6.704 1.00 56.55 ? 57 GLU A OE1 1 ATOM 330 O OE2 . GLU A 1 41 ? 16.605 18.303 -4.679 1.00 56.45 ? 57 GLU A OE2 1 ATOM 331 N N . ASN A 1 42 ? 21.183 16.152 -3.102 1.00 50.54 ? 58 ASN A N 1 ATOM 332 C CA . ASN A 1 42 ? 21.034 15.595 -1.762 1.00 50.30 ? 58 ASN A CA 1 ATOM 333 C C . ASN A 1 42 ? 22.305 15.714 -0.926 1.00 50.21 ? 58 ASN A C 1 ATOM 334 O O . ASN A 1 42 ? 22.232 15.871 0.292 1.00 50.06 ? 58 ASN A O 1 ATOM 335 C CB . ASN A 1 42 ? 20.564 14.141 -1.828 1.00 50.28 ? 58 ASN A CB 1 ATOM 336 C CG . ASN A 1 42 ? 19.070 14.018 -2.095 1.00 50.42 ? 58 ASN A CG 1 ATOM 337 O OD1 . ASN A 1 42 ? 18.310 14.972 -1.918 1.00 50.34 ? 58 ASN A OD1 1 ATOM 338 N ND2 . ASN A 1 42 ? 18.643 12.832 -2.513 1.00 50.10 ? 58 ASN A ND2 1 ATOM 339 N N . GLU A 1 43 ? 23.458 15.642 -1.593 1.00 50.23 ? 59 GLU A N 1 ATOM 340 C CA . GLU A 1 43 ? 24.755 15.859 -0.953 1.00 50.40 ? 59 GLU A CA 1 ATOM 341 C C . GLU A 1 43 ? 24.818 17.272 -0.372 1.00 50.34 ? 59 GLU A C 1 ATOM 342 O O . GLU A 1 43 ? 25.090 17.456 0.820 1.00 50.16 ? 59 GLU A O 1 ATOM 343 C CB . GLU A 1 43 ? 25.898 15.641 -1.951 1.00 50.50 ? 59 GLU A CB 1 ATOM 344 C CG . GLU A 1 43 ? 27.291 15.825 -1.347 1.00 51.52 ? 59 GLU A CG 1 ATOM 345 C CD . GLU A 1 43 ? 28.411 15.857 -2.382 1.00 53.18 ? 59 GLU A CD 1 ATOM 346 O OE1 . GLU A 1 43 ? 28.136 15.781 -3.601 1.00 54.36 ? 59 GLU A OE1 1 ATOM 347 O OE2 . GLU A 1 43 ? 29.584 15.963 -1.968 1.00 54.00 ? 59 GLU A OE2 1 ATOM 348 N N . LYS A 1 44 ? 24.538 18.253 -1.229 1.00 50.16 ? 60 LYS A N 1 ATOM 349 C CA . LYS A 1 44 ? 24.508 19.661 -0.856 1.00 50.14 ? 60 LYS A CA 1 ATOM 350 C C . LYS A 1 44 ? 23.573 19.898 0.334 1.00 49.70 ? 60 LYS A C 1 ATOM 351 O O . LYS A 1 44 ? 23.949 20.569 1.296 1.00 49.66 ? 60 LYS A O 1 ATOM 352 C CB . LYS A 1 44 ? 24.092 20.505 -2.065 1.00 50.25 ? 60 LYS A CB 1 ATOM 353 C CG . LYS A 1 44 ? 24.521 21.962 -2.007 1.00 51.71 ? 60 LYS A CG 1 ATOM 354 C CD . LYS A 1 44 ? 24.356 22.639 -3.371 1.00 52.96 ? 60 LYS A CD 1 ATOM 355 C CE . LYS A 1 44 ? 24.613 24.144 -3.294 1.00 54.06 ? 60 LYS A CE 1 ATOM 356 N NZ . LYS A 1 44 ? 23.495 24.883 -2.628 1.00 54.53 ? 60 LYS A NZ 1 ATOM 357 N N . LYS A 1 45 ? 22.372 19.323 0.270 1.00 49.21 ? 61 LYS A N 1 ATOM 358 C CA . LYS A 1 45 ? 21.393 19.439 1.349 1.00 48.91 ? 61 LYS A CA 1 ATOM 359 C C . LYS A 1 45 ? 21.902 18.833 2.657 1.00 48.38 ? 61 LYS A C 1 ATOM 360 O O . LYS A 1 45 ? 21.754 19.439 3.716 1.00 48.29 ? 61 LYS A O 1 ATOM 361 C CB . LYS A 1 45 ? 20.062 18.789 0.957 1.00 49.17 ? 61 LYS A CB 1 ATOM 362 C CG . LYS A 1 45 ? 19.256 19.574 -0.066 1.00 50.30 ? 61 LYS A CG 1 ATOM 363 C CD . LYS A 1 45 ? 17.899 18.933 -0.284 1.00 52.11 ? 61 LYS A CD 1 ATOM 364 C CE . LYS A 1 45 ? 17.248 19.444 -1.557 1.00 53.31 ? 61 LYS A CE 1 ATOM 365 N NZ . LYS A 1 45 ? 15.976 18.715 -1.829 1.00 54.80 ? 61 LYS A NZ 1 ATOM 366 N N . LYS A 1 46 ? 22.494 17.642 2.570 1.00 47.54 ? 62 LYS A N 1 ATOM 367 C CA . LYS A 1 46 ? 23.040 16.945 3.735 1.00 46.98 ? 62 LYS A CA 1 ATOM 368 C C . LYS A 1 46 ? 24.093 17.801 4.438 1.00 46.23 ? 62 LYS A C 1 ATOM 369 O O . LYS A 1 46 ? 24.030 18.010 5.649 1.00 46.02 ? 62 LYS A O 1 ATOM 370 C CB . LYS A 1 46 ? 23.650 15.596 3.319 1.00 47.03 ? 62 LYS A CB 1 ATOM 371 C CG . LYS A 1 46 ? 24.278 14.809 4.467 1.00 47.71 ? 62 LYS A CG 1 ATOM 372 C CD . LYS A 1 46 ? 25.210 13.708 3.977 1.00 48.10 ? 62 LYS A CD 1 ATOM 373 C CE . LYS A 1 46 ? 25.963 13.073 5.152 1.00 48.78 ? 62 LYS A CE 1 ATOM 374 N NZ . LYS A 1 46 ? 26.725 11.854 4.751 1.00 48.56 ? 62 LYS A NZ 1 ATOM 375 N N . ASN A 1 47 ? 25.047 18.296 3.654 1.00 45.52 ? 63 ASN A N 1 ATOM 376 C CA . ASN A 1 47 ? 26.196 19.030 4.171 1.00 44.89 ? 63 ASN A CA 1 ATOM 377 C C . ASN A 1 47 ? 25.860 20.428 4.706 1.00 44.81 ? 63 ASN A C 1 ATOM 378 O O . ASN A 1 47 ? 26.464 20.887 5.682 1.00 44.64 ? 63 ASN A O 1 ATOM 379 C CB . ASN A 1 47 ? 27.308 19.079 3.114 1.00 44.63 ? 63 ASN A CB 1 ATOM 380 C CG . ASN A 1 47 ? 27.930 17.705 2.846 1.00 43.81 ? 63 ASN A CG 1 ATOM 381 O OD1 . ASN A 1 47 ? 27.792 16.782 3.648 1.00 42.19 ? 63 ASN A OD1 1 ATOM 382 N ND2 . ASN A 1 47 ? 28.621 17.572 1.717 1.00 42.61 ? 63 ASN A ND2 1 ATOM 383 N N . GLU A 1 48 ? 24.880 21.087 4.089 1.00 44.57 ? 64 GLU A N 1 ATOM 384 C CA . GLU A 1 48 ? 24.465 22.418 4.532 1.00 44.47 ? 64 GLU A CA 1 ATOM 385 C C . GLU A 1 48 ? 23.716 22.394 5.868 1.00 43.99 ? 64 GLU A C 1 ATOM 386 O O . GLU A 1 48 ? 23.927 23.276 6.708 1.00 43.68 ? 64 GLU A O 1 ATOM 387 C CB . GLU A 1 48 ? 23.683 23.155 3.435 1.00 44.85 ? 64 GLU A CB 1 ATOM 388 C CG . GLU A 1 48 ? 24.607 23.707 2.332 1.00 46.64 ? 64 GLU A CG 1 ATOM 389 C CD . GLU A 1 48 ? 23.873 24.357 1.160 1.00 49.63 ? 64 GLU A CD 1 ATOM 390 O OE1 . GLU A 1 48 ? 22.635 24.539 1.230 1.00 50.46 ? 64 GLU A OE1 1 ATOM 391 O OE2 . GLU A 1 48 ? 24.550 24.690 0.159 1.00 50.62 ? 64 GLU A OE2 1 ATOM 392 N N . ILE A 1 49 ? 22.875 21.376 6.071 1.00 43.29 ? 65 ILE A N 1 ATOM 393 C CA . ILE A 1 49 ? 22.187 21.189 7.354 1.00 42.94 ? 65 ILE A CA 1 ATOM 394 C C . ILE A 1 49 ? 23.204 20.937 8.470 1.00 42.52 ? 65 ILE A C 1 ATOM 395 O O . ILE A 1 49 ? 23.077 21.485 9.568 1.00 42.38 ? 65 ILE A O 1 ATOM 396 C CB . ILE A 1 49 ? 21.162 20.008 7.339 1.00 42.93 ? 65 ILE A CB 1 ATOM 397 C CG1 . ILE A 1 49 ? 20.305 19.987 6.055 1.00 44.02 ? 65 ILE A CG1 1 ATOM 398 C CG2 . ILE A 1 49 ? 20.301 20.022 8.598 1.00 42.59 ? 65 ILE A CG2 1 ATOM 399 C CD1 . ILE A 1 49 ? 19.343 21.165 5.841 1.00 44.47 ? 65 ILE A CD1 1 ATOM 400 N N . SER A 1 50 ? 24.201 20.099 8.176 1.00 42.19 ? 66 SER A N 1 ATOM 401 C CA . SER A 1 50 ? 25.254 19.751 9.134 1.00 41.92 ? 66 SER A CA 1 ATOM 402 C C . SER A 1 50 ? 26.089 20.960 9.524 1.00 41.48 ? 66 SER A C 1 ATOM 403 O O . SER A 1 50 ? 26.423 21.126 10.695 1.00 41.22 ? 66 SER A O 1 ATOM 404 C CB . SER A 1 50 ? 26.159 18.651 8.582 1.00 41.82 ? 66 SER A CB 1 ATOM 405 O OG . SER A 1 50 ? 25.502 17.401 8.611 1.00 42.81 ? 66 SER A OG 1 ATOM 406 N N . ALA A 1 51 ? 26.420 21.794 8.537 1.00 41.15 ? 67 ALA A N 1 ATOM 407 C CA . ALA A 1 51 ? 27.116 23.060 8.771 1.00 40.98 ? 67 ALA A CA 1 ATOM 408 C C . ALA A 1 51 ? 26.318 23.956 9.727 1.00 41.07 ? 67 ALA A C 1 ATOM 409 O O . ALA A 1 51 ? 26.890 24.623 10.597 1.00 41.00 ? 67 ALA A O 1 ATOM 410 C CB . ALA A 1 51 ? 27.370 23.774 7.454 1.00 40.91 ? 67 ALA A CB 1 ATOM 411 N N . GLU A 1 52 ? 24.996 23.946 9.564 1.00 40.86 ? 68 GLU A N 1 ATOM 412 C CA . GLU A 1 52 ? 24.093 24.711 10.412 1.00 40.76 ? 68 GLU A CA 1 ATOM 413 C C . GLU A 1 52 ? 24.096 24.173 11.843 1.00 40.67 ? 68 GLU A C 1 ATOM 414 O O . GLU A 1 52 ? 24.160 24.948 12.798 1.00 40.61 ? 68 GLU A O 1 ATOM 415 C CB . GLU A 1 52 ? 22.680 24.693 9.822 0.50 40.65 ? 68 GLU A CB 1 ATOM 416 C CG . GLU A 1 52 ? 21.676 25.582 10.524 0.50 40.32 ? 68 GLU A CG 1 ATOM 417 C CD . GLU A 1 52 ? 20.354 25.643 9.785 0.50 40.45 ? 68 GLU A CD 1 ATOM 418 O OE1 . GLU A 1 52 ? 20.349 25.419 8.553 0.50 39.35 ? 68 GLU A OE1 1 ATOM 419 O OE2 . GLU A 1 52 ? 19.323 25.915 10.434 0.50 40.57 ? 68 GLU A OE2 1 ATOM 420 N N . LEU A 1 53 ? 24.030 22.851 11.988 1.00 40.59 ? 69 LEU A N 1 ATOM 421 C CA . LEU A 1 53 ? 24.052 22.237 13.314 1.00 40.65 ? 69 LEU A CA 1 ATOM 422 C C . LEU A 1 53 ? 25.418 22.406 13.982 1.00 40.59 ? 69 LEU A C 1 ATOM 423 O O . LEU A 1 53 ? 25.498 22.618 15.189 1.00 40.41 ? 69 LEU A O 1 ATOM 424 C CB . LEU A 1 53 ? 23.647 20.755 13.257 1.00 40.62 ? 69 LEU A CB 1 ATOM 425 C CG . LEU A 1 53 ? 23.609 19.976 14.583 1.00 40.89 ? 69 LEU A CG 1 ATOM 426 C CD1 . LEU A 1 53 ? 22.607 20.558 15.571 1.00 41.01 ? 69 LEU A CD1 1 ATOM 427 C CD2 . LEU A 1 53 ? 23.317 18.509 14.348 1.00 41.88 ? 69 LEU A CD2 1 ATOM 428 N N . ALA A 1 54 ? 26.483 22.322 13.190 1.00 40.79 ? 70 ALA A N 1 ATOM 429 C CA . ALA A 1 54 ? 27.841 22.530 13.698 1.00 41.33 ? 70 ALA A CA 1 ATOM 430 C C . ALA A 1 54 ? 27.975 23.916 14.327 1.00 41.69 ? 70 ALA A C 1 ATOM 431 O O . ALA A 1 54 ? 28.553 24.066 15.411 1.00 41.66 ? 70 ALA A O 1 ATOM 432 C CB . ALA A 1 54 ? 28.863 22.345 12.591 1.00 41.11 ? 70 ALA A CB 1 ATOM 433 N N . LYS A 1 55 ? 27.417 24.918 13.647 1.00 41.99 ? 71 LYS A N 1 ATOM 434 C CA . LYS A 1 55 ? 27.434 26.294 14.134 1.00 42.50 ? 71 LYS A CA 1 ATOM 435 C C . LYS A 1 55 ? 26.684 26.431 15.454 1.00 42.33 ? 71 LYS A C 1 ATOM 436 O O . LYS A 1 55 ? 27.124 27.157 16.345 1.00 42.32 ? 71 LYS A O 1 ATOM 437 C CB . LYS A 1 55 ? 26.849 27.244 13.089 1.00 42.75 ? 71 LYS A CB 1 ATOM 438 C CG . LYS A 1 55 ? 27.184 28.703 13.340 1.00 44.37 ? 71 LYS A CG 1 ATOM 439 C CD . LYS A 1 55 ? 26.763 29.576 12.173 1.00 46.79 ? 71 LYS A CD 1 ATOM 440 C CE . LYS A 1 55 ? 27.307 30.987 12.337 1.00 48.23 ? 71 LYS A CE 1 ATOM 441 N NZ . LYS A 1 55 ? 26.758 31.902 11.294 1.00 49.85 ? 71 LYS A NZ 1 ATOM 442 N N . PHE A 1 56 ? 25.557 25.731 15.573 1.00 42.23 ? 72 PHE A N 1 ATOM 443 C CA . PHE A 1 56 ? 24.771 25.743 16.803 1.00 42.29 ? 72 PHE A CA 1 ATOM 444 C C . PHE A 1 56 ? 25.523 25.067 17.961 1.00 42.36 ? 72 PHE A C 1 ATOM 445 O O . PHE A 1 56 ? 25.477 25.544 19.096 1.00 42.24 ? 72 PHE A O 1 ATOM 446 C CB . PHE A 1 56 ? 23.395 25.099 16.578 1.00 42.08 ? 72 PHE A CB 1 ATOM 447 C CG . PHE A 1 56 ? 22.520 25.092 17.802 1.00 42.34 ? 72 PHE A CG 1 ATOM 448 C CD1 . PHE A 1 56 ? 21.819 26.236 18.180 1.00 42.49 ? 72 PHE A CD1 1 ATOM 449 C CD2 . PHE A 1 56 ? 22.401 23.945 18.582 1.00 41.60 ? 72 PHE A CD2 1 ATOM 450 C CE1 . PHE A 1 56 ? 21.014 26.235 19.321 1.00 42.38 ? 72 PHE A CE1 1 ATOM 451 C CE2 . PHE A 1 56 ? 21.600 23.936 19.721 1.00 41.87 ? 72 PHE A CE2 1 ATOM 452 C CZ . PHE A 1 56 ? 20.904 25.083 20.090 1.00 42.17 ? 72 PHE A CZ 1 ATOM 453 N N . MET A 1 57 ? 26.212 23.966 17.666 1.00 42.59 ? 73 MET A N 1 ATOM 454 C CA . MET A 1 57 ? 27.021 23.255 18.666 1.00 43.07 ? 73 MET A CA 1 ATOM 455 C C . MET A 1 57 ? 28.159 24.115 19.211 1.00 42.92 ? 73 MET A C 1 ATOM 456 O O . MET A 1 57 ? 28.464 24.065 20.406 1.00 42.67 ? 73 MET A O 1 ATOM 457 C CB . MET A 1 57 ? 27.583 21.945 18.098 1.00 43.26 ? 73 MET A CB 1 ATOM 458 C CG . MET A 1 57 ? 26.541 20.890 17.775 1.00 44.66 ? 73 MET A CG 1 ATOM 459 S SD . MET A 1 57 ? 25.307 20.700 19.075 1.00 48.66 ? 73 MET A SD 1 ATOM 460 C CE . MET A 1 57 ? 26.252 19.915 20.386 1.00 47.81 ? 73 MET A CE 1 ATOM 461 N N . LYS A 1 58 ? 28.779 24.896 18.325 1.00 43.01 ? 74 LYS A N 1 ATOM 462 C CA . LYS A 1 58 ? 29.823 25.852 18.701 1.00 43.33 ? 74 LYS A CA 1 ATOM 463 C C . LYS A 1 58 ? 29.356 26.805 19.794 1.00 43.28 ? 74 LYS A C 1 ATOM 464 O O . LYS A 1 58 ? 30.091 27.072 20.748 1.00 43.24 ? 74 LYS A O 1 ATOM 465 C CB . LYS A 1 58 ? 30.270 26.666 17.490 1.00 43.36 ? 74 LYS A CB 1 ATOM 466 C CG . LYS A 1 58 ? 31.547 26.193 16.837 1.00 44.32 ? 74 LYS A CG 1 ATOM 467 C CD . LYS A 1 58 ? 32.120 27.305 15.968 1.00 44.86 ? 74 LYS A CD 1 ATOM 468 C CE . LYS A 1 58 ? 33.151 26.791 14.990 1.00 45.22 ? 74 LYS A CE 1 ATOM 469 N NZ . LYS A 1 58 ? 32.536 25.883 13.978 1.00 46.36 ? 74 LYS A NZ 1 ATOM 470 N N . GLU A 1 59 ? 28.133 27.315 19.644 1.00 43.14 ? 75 GLU A N 1 ATOM 471 C CA . GLU A 1 59 ? 27.543 28.202 20.642 1.00 43.21 ? 75 GLU A CA 1 ATOM 472 C C . GLU A 1 59 ? 27.181 27.454 21.920 1.00 43.03 ? 75 GLU A C 1 ATOM 473 O O . GLU A 1 59 ? 27.312 28.001 23.019 1.00 42.97 ? 75 GLU A O 1 ATOM 474 C CB . GLU A 1 59 ? 26.332 28.953 20.075 0.50 43.21 ? 75 GLU A CB 1 ATOM 475 C CG . GLU A 1 59 ? 26.681 29.937 18.960 0.50 43.95 ? 75 GLU A CG 1 ATOM 476 C CD . GLU A 1 59 ? 27.896 30.797 19.289 0.50 45.04 ? 75 GLU A CD 1 ATOM 477 O OE1 . GLU A 1 59 ? 27.851 31.540 20.296 0.50 45.29 ? 75 GLU A OE1 1 ATOM 478 O OE2 . GLU A 1 59 ? 28.896 30.721 18.542 0.50 45.03 ? 75 GLU A OE2 1 ATOM 479 N N . VAL A 1 60 ? 26.740 26.205 21.769 1.00 42.84 ? 76 VAL A N 1 ATOM 480 C CA . VAL A 1 60 ? 26.463 25.338 22.916 1.00 42.96 ? 76 VAL A CA 1 ATOM 481 C C . VAL A 1 60 ? 27.739 25.139 23.754 1.00 43.12 ? 76 VAL A C 1 ATOM 482 O O . VAL A 1 60 ? 27.738 25.407 24.956 1.00 42.94 ? 76 VAL A O 1 ATOM 483 C CB . VAL A 1 60 ? 25.842 23.969 22.485 1.00 42.98 ? 76 VAL A CB 1 ATOM 484 C CG1 . VAL A 1 60 ? 25.812 22.984 23.648 1.00 42.65 ? 76 VAL A CG1 1 ATOM 485 C CG2 . VAL A 1 60 ? 24.441 24.167 21.924 1.00 42.69 ? 76 VAL A CG2 1 ATOM 486 N N . ALA A 1 61 ? 28.817 24.697 23.105 1.00 43.29 ? 77 ALA A N 1 ATOM 487 C CA . ALA A 1 61 ? 30.103 24.488 23.768 1.00 43.91 ? 77 ALA A CA 1 ATOM 488 C C . ALA A 1 61 ? 30.574 25.755 24.474 1.00 44.33 ? 77 ALA A C 1 ATOM 489 O O . ALA A 1 61 ? 31.070 25.696 25.602 1.00 44.41 ? 77 ALA A O 1 ATOM 490 C CB . ALA A 1 61 ? 31.147 24.011 22.778 1.00 43.41 ? 77 ALA A CB 1 ATOM 491 N N . SER A 1 62 ? 30.404 26.893 23.804 1.00 44.80 ? 78 SER A N 1 ATOM 492 C CA . SER A 1 62 ? 30.699 28.195 24.384 1.00 45.34 ? 78 SER A CA 1 ATOM 493 C C . SER A 1 62 ? 29.852 28.486 25.628 1.00 45.58 ? 78 SER A C 1 ATOM 494 O O . SER A 1 62 ? 30.384 28.950 26.638 1.00 45.77 ? 78 SER A O 1 ATOM 495 C CB . SER A 1 62 ? 30.516 29.297 23.339 1.00 45.46 ? 78 SER A CB 1 ATOM 496 O OG . SER A 1 62 ? 30.535 30.579 23.939 1.00 46.15 ? 78 SER A OG 1 ATOM 497 N N . ASP A 1 63 ? 28.551 28.205 25.554 1.00 45.65 ? 79 ASP A N 1 ATOM 498 C CA . ASP A 1 63 ? 27.628 28.473 26.664 1.00 45.99 ? 79 ASP A CA 1 ATOM 499 C C . ASP A 1 63 ? 27.895 27.638 27.914 1.00 45.85 ? 79 ASP A C 1 ATOM 500 O O . ASP A 1 63 ? 27.534 28.047 29.019 1.00 46.08 ? 79 ASP A O 1 ATOM 501 C CB . ASP A 1 63 ? 26.166 28.291 26.230 1.00 46.16 ? 79 ASP A CB 1 ATOM 502 C CG . ASP A 1 63 ? 25.614 29.497 25.479 1.00 47.00 ? 79 ASP A CG 1 ATOM 503 O OD1 . ASP A 1 63 ? 26.285 30.554 25.431 1.00 47.73 ? 79 ASP A OD1 1 ATOM 504 O OD2 . ASP A 1 63 ? 24.495 29.381 24.934 1.00 47.82 ? 79 ASP A OD2 1 ATOM 505 N N . THR A 1 64 ? 28.512 26.470 27.743 1.00 45.80 ? 80 THR A N 1 ATOM 506 C CA . THR A 1 64 ? 28.858 25.616 28.882 1.00 45.73 ? 80 THR A CA 1 ATOM 507 C C . THR A 1 64 ? 29.862 26.298 29.818 1.00 45.77 ? 80 THR A C 1 ATOM 508 O O . THR A 1 64 ? 29.861 26.049 31.029 1.00 45.92 ? 80 THR A O 1 ATOM 509 C CB . THR A 1 64 ? 29.409 24.230 28.450 1.00 45.70 ? 80 THR A CB 1 ATOM 510 O OG1 . THR A 1 64 ? 30.678 24.381 27.803 1.00 45.50 ? 80 THR A OG1 1 ATOM 511 C CG2 . THR A 1 64 ? 28.440 23.517 27.518 1.00 45.68 ? 80 THR A CG2 1 ATOM 512 N N . THR A 1 65 ? 30.699 27.172 29.256 1.00 45.67 ? 81 THR A N 1 ATOM 513 C CA . THR A 1 65 ? 31.727 27.868 30.035 1.00 45.61 ? 81 THR A CA 1 ATOM 514 C C . THR A 1 65 ? 31.130 28.929 30.961 1.00 45.46 ? 81 THR A C 1 ATOM 515 O O . THR A 1 65 ? 31.797 29.396 31.880 1.00 45.77 ? 81 THR A O 1 ATOM 516 C CB . THR A 1 65 ? 32.828 28.504 29.146 1.00 45.57 ? 81 THR A CB 1 ATOM 517 O OG1 . THR A 1 65 ? 32.293 29.625 28.436 1.00 45.81 ? 81 THR A OG1 1 ATOM 518 C CG2 . THR A 1 65 ? 33.392 27.494 28.157 1.00 45.59 ? 81 THR A CG2 1 ATOM 519 N N . LYS A 1 66 ? 29.874 29.297 30.719 1.00 45.03 ? 82 LYS A N 1 ATOM 520 C CA . LYS A 1 66 ? 29.160 30.229 31.591 1.00 44.48 ? 82 LYS A CA 1 ATOM 521 C C . LYS A 1 66 ? 28.616 29.545 32.847 1.00 43.70 ? 82 LYS A C 1 ATOM 522 O O . LYS A 1 66 ? 28.265 30.213 33.822 1.00 43.73 ? 82 LYS A O 1 ATOM 523 C CB . LYS A 1 66 ? 28.039 30.935 30.825 1.00 44.66 ? 82 LYS A CB 1 ATOM 524 C CG . LYS A 1 66 ? 28.546 31.904 29.759 1.00 46.34 ? 82 LYS A CG 1 ATOM 525 C CD . LYS A 1 66 ? 27.392 32.553 29.001 1.00 49.32 ? 82 LYS A CD 1 ATOM 526 C CE . LYS A 1 66 ? 27.901 33.457 27.877 1.00 50.56 ? 82 LYS A CE 1 ATOM 527 N NZ . LYS A 1 66 ? 26.817 34.342 27.357 1.00 51.82 ? 82 LYS A NZ 1 ATOM 528 N N . PHE A 1 67 ? 28.548 28.215 32.816 1.00 42.65 ? 83 PHE A N 1 ATOM 529 C CA . PHE A 1 67 ? 28.147 27.425 33.978 1.00 41.56 ? 83 PHE A CA 1 ATOM 530 C C . PHE A 1 67 ? 29.366 26.867 34.702 1.00 40.88 ? 83 PHE A C 1 ATOM 531 O O . PHE A 1 67 ? 30.285 26.346 34.067 1.00 40.47 ? 83 PHE A O 1 ATOM 532 C CB . PHE A 1 67 ? 27.240 26.261 33.562 1.00 41.63 ? 83 PHE A CB 1 ATOM 533 C CG . PHE A 1 67 ? 25.874 26.680 33.083 1.00 41.56 ? 83 PHE A CG 1 ATOM 534 C CD1 . PHE A 1 67 ? 24.828 26.858 33.988 1.00 42.20 ? 83 PHE A CD1 1 ATOM 535 C CD2 . PHE A 1 67 ? 25.628 26.876 31.728 1.00 41.08 ? 83 PHE A CD2 1 ATOM 536 C CE1 . PHE A 1 67 ? 23.552 27.240 33.542 1.00 42.71 ? 83 PHE A CE1 1 ATOM 537 C CE2 . PHE A 1 67 ? 24.361 27.254 31.272 1.00 41.63 ? 83 PHE A CE2 1 ATOM 538 C CZ . PHE A 1 67 ? 23.322 27.434 32.177 1.00 41.91 ? 83 PHE A CZ 1 ATOM 539 N N . GLN A 1 68 ? 29.356 26.969 36.032 1.00 40.06 ? 84 GLN A N 1 ATOM 540 C CA . GLN A 1 68 ? 30.401 26.401 36.883 1.00 39.36 ? 84 GLN A CA 1 ATOM 541 C C . GLN A 1 68 ? 30.220 24.895 37.035 1.00 38.50 ? 84 GLN A C 1 ATOM 542 O O . GLN A 1 68 ? 30.224 24.377 38.159 1.00 38.14 ? 84 GLN A O 1 ATOM 543 C CB . GLN A 1 68 ? 30.368 27.054 38.275 1.00 39.87 ? 84 GLN A CB 1 ATOM 544 C CG . GLN A 1 68 ? 30.574 28.565 38.288 1.00 40.98 ? 84 GLN A CG 1 ATOM 545 C CD . GLN A 1 68 ? 31.893 28.968 37.677 1.00 42.93 ? 84 GLN A CD 1 ATOM 546 O OE1 . GLN A 1 68 ? 32.924 28.341 37.931 1.00 44.91 ? 84 GLN A OE1 1 ATOM 547 N NE2 . GLN A 1 68 ? 31.871 30.011 36.858 1.00 43.05 ? 84 GLN A NE2 1 ATOM 548 N N . TRP A 1 69 ? 30.075 24.186 35.914 1.00 37.50 ? 85 TRP A N 1 ATOM 549 C CA . TRP A 1 69 ? 29.614 22.796 35.965 1.00 36.76 ? 85 TRP A CA 1 ATOM 550 C C . TRP A 1 69 ? 30.530 21.822 36.713 1.00 36.57 ? 85 TRP A C 1 ATOM 551 O O . TRP A 1 69 ? 30.041 20.929 37.407 1.00 36.35 ? 85 TRP A O 1 ATOM 552 C CB . TRP A 1 69 ? 29.194 22.268 34.581 1.00 36.77 ? 85 TRP A CB 1 ATOM 553 C CG . TRP A 1 69 ? 30.291 22.123 33.565 1.00 35.56 ? 85 TRP A CG 1 ATOM 554 C CD1 . TRP A 1 69 ? 30.621 23.013 32.581 1.00 34.33 ? 85 TRP A CD1 1 ATOM 555 C CD2 . TRP A 1 69 ? 31.169 21.001 33.403 1.00 34.82 ? 85 TRP A CD2 1 ATOM 556 N NE1 . TRP A 1 69 ? 31.660 22.522 31.826 1.00 34.32 ? 85 TRP A NE1 1 ATOM 557 C CE2 . TRP A 1 69 ? 32.017 21.289 32.309 1.00 34.76 ? 85 TRP A CE2 1 ATOM 558 C CE3 . TRP A 1 69 ? 31.325 19.781 34.077 1.00 34.29 ? 85 TRP A CE3 1 ATOM 559 C CZ2 . TRP A 1 69 ? 33.013 20.404 31.878 1.00 34.49 ? 85 TRP A CZ2 1 ATOM 560 C CZ3 . TRP A 1 69 ? 32.312 18.901 33.648 1.00 33.73 ? 85 TRP A CZ3 1 ATOM 561 C CH2 . TRP A 1 69 ? 33.144 19.218 32.556 1.00 34.48 ? 85 TRP A CH2 1 ATOM 562 N N . ARG A 1 70 ? 31.844 22.020 36.609 1.00 36.24 ? 86 ARG A N 1 ATOM 563 C CA . ARG A 1 70 ? 32.810 21.200 37.354 1.00 36.12 ? 86 ARG A CA 1 ATOM 564 C C . ARG A 1 70 ? 32.666 21.346 38.872 1.00 36.16 ? 86 ARG A C 1 ATOM 565 O O . ARG A 1 70 ? 33.179 20.517 39.626 1.00 36.36 ? 86 ARG A O 1 ATOM 566 C CB . ARG A 1 70 ? 34.252 21.517 36.935 1.00 36.09 ? 86 ARG A CB 1 ATOM 567 C CG . ARG A 1 70 ? 34.592 21.112 35.509 1.00 35.05 ? 86 ARG A CG 1 ATOM 568 C CD . ARG A 1 70 ? 35.996 21.543 35.122 1.00 33.81 ? 86 ARG A CD 1 ATOM 569 N NE . ARG A 1 70 ? 36.295 21.205 33.729 1.00 33.18 ? 86 ARG A NE 1 ATOM 570 C CZ . ARG A 1 70 ? 36.024 21.984 32.683 1.00 33.05 ? 86 ARG A CZ 1 ATOM 571 N NH1 . ARG A 1 70 ? 35.449 23.167 32.855 1.00 32.32 ? 86 ARG A NH1 1 ATOM 572 N NH2 . ARG A 1 70 ? 36.336 21.579 31.458 1.00 33.71 ? 86 ARG A NH2 1 ATOM 573 N N . SER A 1 71 ? 31.964 22.390 39.311 1.00 36.27 ? 87 SER A N 1 ATOM 574 C CA . SER A 1 71 ? 31.752 22.641 40.742 1.00 36.36 ? 87 SER A CA 1 ATOM 575 C C . SER A 1 71 ? 30.485 21.987 41.297 1.00 36.60 ? 87 SER A C 1 ATOM 576 O O . SER A 1 71 ? 30.240 22.030 42.512 1.00 36.79 ? 87 SER A O 1 ATOM 577 C CB . SER A 1 71 ? 31.714 24.147 41.028 1.00 36.31 ? 87 SER A CB 1 ATOM 578 O OG . SER A 1 71 ? 32.942 24.774 40.703 1.00 36.00 ? 87 SER A OG 1 ATOM 579 N N . TYR A 1 72 ? 29.684 21.376 40.425 1.00 36.43 ? 88 TYR A N 1 ATOM 580 C CA . TYR A 1 72 ? 28.373 20.858 40.839 1.00 36.40 ? 88 TYR A CA 1 ATOM 581 C C . TYR A 1 72 ? 28.433 19.602 41.715 1.00 36.37 ? 88 TYR A C 1 ATOM 582 O O . TYR A 1 72 ? 29.408 18.845 41.678 1.00 36.02 ? 88 TYR A O 1 ATOM 583 C CB . TYR A 1 72 ? 27.459 20.622 39.625 1.00 36.35 ? 88 TYR A CB 1 ATOM 584 C CG . TYR A 1 72 ? 27.077 21.874 38.863 1.00 36.06 ? 88 TYR A CG 1 ATOM 585 C CD1 . TYR A 1 72 ? 27.206 23.141 39.434 1.00 36.43 ? 88 TYR A CD1 1 ATOM 586 C CD2 . TYR A 1 72 ? 26.559 21.785 37.569 1.00 37.22 ? 88 TYR A CD2 1 ATOM 587 C CE1 . TYR A 1 72 ? 26.855 24.288 38.725 1.00 37.21 ? 88 TYR A CE1 1 ATOM 588 C CE2 . TYR A 1 72 ? 26.197 22.922 36.854 1.00 36.77 ? 88 TYR A CE2 1 ATOM 589 C CZ . TYR A 1 72 ? 26.347 24.167 37.434 1.00 37.08 ? 88 TYR A CZ 1 ATOM 590 O OH . TYR A 1 72 ? 25.991 25.289 36.721 1.00 37.37 ? 88 TYR A OH 1 ATOM 591 N N . GLN A 1 73 ? 27.379 19.402 42.505 1.00 36.42 ? 89 GLN A N 1 ATOM 592 C CA . GLN A 1 73 ? 27.235 18.215 43.347 1.00 36.87 ? 89 GLN A CA 1 ATOM 593 C C . GLN A 1 73 ? 26.800 16.999 42.523 1.00 37.03 ? 89 GLN A C 1 ATOM 594 O O . GLN A 1 73 ? 27.241 15.872 42.767 1.00 37.12 ? 89 GLN A O 1 ATOM 595 C CB . GLN A 1 73 ? 26.205 18.472 44.455 1.00 36.89 ? 89 GLN A CB 1 ATOM 596 C CG . GLN A 1 73 ? 26.638 19.504 45.507 1.00 37.36 ? 89 GLN A CG 1 ATOM 597 C CD . GLN A 1 73 ? 27.773 19.008 46.387 1.00 37.21 ? 89 GLN A CD 1 ATOM 598 O OE1 . GLN A 1 73 ? 27.745 17.883 46.881 1.00 37.85 ? 89 GLN A OE1 1 ATOM 599 N NE2 . GLN A 1 73 ? 28.782 19.847 46.577 1.00 37.54 ? 89 GLN A NE2 1 ATOM 600 N N . SER A 1 74 ? 25.931 17.238 41.549 1.00 37.19 ? 90 SER A N 1 ATOM 601 C CA . SER A 1 74 ? 25.321 16.162 40.780 1.00 37.53 ? 90 SER A CA 1 ATOM 602 C C . SER A 1 74 ? 26.272 15.611 39.725 1.00 37.58 ? 90 SER A C 1 ATOM 603 O O . SER A 1 74 ? 26.605 16.300 38.758 1.00 37.38 ? 90 SER A O 1 ATOM 604 C CB . SER A 1 74 ? 24.022 16.642 40.130 1.00 37.41 ? 90 SER A CB 1 ATOM 605 O OG . SER A 1 74 ? 23.503 15.662 39.247 1.00 38.27 ? 90 SER A OG 1 ATOM 606 N N . GLU A 1 75 ? 26.698 14.365 39.926 1.00 37.92 ? 91 GLU A N 1 ATOM 607 C CA . GLU A 1 75 ? 27.499 13.633 38.943 1.00 38.58 ? 91 GLU A CA 1 ATOM 608 C C . GLU A 1 75 ? 26.792 13.584 37.597 1.00 38.10 ? 91 GLU A C 1 ATOM 609 O O . GLU A 1 75 ? 27.432 13.685 36.551 1.00 38.02 ? 91 GLU A O 1 ATOM 610 C CB . GLU A 1 75 ? 27.773 12.199 39.418 1.00 39.01 ? 91 GLU A CB 1 ATOM 611 C CG . GLU A 1 75 ? 28.762 12.076 40.574 1.00 41.76 ? 91 GLU A CG 1 ATOM 612 C CD . GLU A 1 75 ? 30.153 12.604 40.239 1.00 45.15 ? 91 GLU A CD 1 ATOM 613 O OE1 . GLU A 1 75 ? 30.628 12.423 39.089 1.00 46.16 ? 91 GLU A OE1 1 ATOM 614 O OE2 . GLU A 1 75 ? 30.770 13.215 41.138 1.00 47.64 ? 91 GLU A OE2 1 ATOM 615 N N . ASP A 1 76 ? 25.467 13.439 37.643 1.00 37.71 ? 92 ASP A N 1 ATOM 616 C CA . ASP A 1 76 ? 24.644 13.350 36.443 1.00 37.28 ? 92 ASP A CA 1 ATOM 617 C C . ASP A 1 76 ? 24.701 14.629 35.624 1.00 36.91 ? 92 ASP A C 1 ATOM 618 O O . ASP A 1 76 ? 24.933 14.578 34.411 1.00 36.76 ? 92 ASP A O 1 ATOM 619 C CB . ASP A 1 76 ? 23.190 13.007 36.793 1.00 37.50 ? 92 ASP A CB 1 ATOM 620 C CG . ASP A 1 76 ? 22.335 12.778 35.557 1.00 38.53 ? 92 ASP A CG 1 ATOM 621 O OD1 . ASP A 1 76 ? 22.633 11.840 34.794 1.00 41.00 ? 92 ASP A OD1 1 ATOM 622 O OD2 . ASP A 1 76 ? 21.369 13.534 35.339 1.00 40.31 ? 92 ASP A OD2 1 ATOM 623 N N . LEU A 1 77 ? 24.499 15.772 36.283 1.00 36.24 ? 93 LEU A N 1 ATOM 624 C CA . LEU A 1 77 ? 24.569 17.064 35.598 1.00 35.91 ? 93 LEU A CA 1 ATOM 625 C C . LEU A 1 77 ? 25.970 17.338 35.044 1.00 35.48 ? 93 LEU A C 1 ATOM 626 O O . LEU A 1 77 ? 26.110 17.835 33.924 1.00 34.85 ? 93 LEU A O 1 ATOM 627 C CB . LEU A 1 77 ? 24.098 18.216 36.497 1.00 36.21 ? 93 LEU A CB 1 ATOM 628 C CG . LEU A 1 77 ? 22.652 18.168 37.019 1.00 37.07 ? 93 LEU A CG 1 ATOM 629 C CD1 . LEU A 1 77 ? 22.350 19.401 37.858 1.00 37.42 ? 93 LEU A CD1 1 ATOM 630 C CD2 . LEU A 1 77 ? 21.626 18.020 35.884 1.00 37.34 ? 93 LEU A CD2 1 ATOM 631 N N . LYS A 1 78 ? 26.996 16.990 35.818 1.00 35.06 ? 94 LYS A N 1 ATOM 632 C CA . LYS A 1 78 ? 28.387 17.150 35.366 1.00 35.06 ? 94 LYS A CA 1 ATOM 633 C C . LYS A 1 78 ? 28.672 16.313 34.120 1.00 34.75 ? 94 LYS A C 1 ATOM 634 O O . LYS A 1 78 ? 29.309 16.790 33.182 1.00 34.66 ? 94 LYS A O 1 ATOM 635 C CB . LYS A 1 78 ? 29.375 16.801 36.481 1.00 34.96 ? 94 LYS A CB 1 ATOM 636 C CG . LYS A 1 78 ? 29.354 17.787 37.643 1.00 35.06 ? 94 LYS A CG 1 ATOM 637 C CD . LYS A 1 78 ? 30.521 17.574 38.597 1.00 35.28 ? 94 LYS A CD 1 ATOM 638 C CE . LYS A 1 78 ? 30.310 16.367 39.481 1.00 35.48 ? 94 LYS A CE 1 ATOM 639 N NZ . LYS A 1 78 ? 31.532 16.082 40.285 1.00 36.19 ? 94 LYS A NZ 1 ATOM 640 N N . ARG A 1 79 ? 28.186 15.074 34.120 1.00 34.75 ? 95 ARG A N 1 ATOM 641 C CA . ARG A 1 79 ? 28.354 14.179 32.978 1.00 34.87 ? 95 ARG A CA 1 ATOM 642 C C . ARG A 1 79 ? 27.696 14.746 31.709 1.00 34.86 ? 95 ARG A C 1 ATOM 643 O O . ARG A 1 79 ? 28.292 14.709 30.628 1.00 34.49 ? 95 ARG A O 1 ATOM 644 C CB . ARG A 1 79 ? 27.828 12.778 33.304 1.00 34.82 ? 95 ARG A CB 1 ATOM 645 C CG . ARG A 1 79 ? 28.078 11.754 32.202 1.00 34.91 ? 95 ARG A CG 1 ATOM 646 C CD . ARG A 1 79 ? 27.716 10.348 32.638 1.00 34.61 ? 95 ARG A CD 1 ATOM 647 N NE . ARG A 1 79 ? 27.930 9.387 31.560 1.00 34.80 ? 95 ARG A NE 1 ATOM 648 C CZ . ARG A 1 79 ? 29.105 8.837 31.250 1.00 35.64 ? 95 ARG A CZ 1 ATOM 649 N NH1 . ARG A 1 79 ? 30.208 9.146 31.933 1.00 34.35 ? 95 ARG A NH1 1 ATOM 650 N NH2 . ARG A 1 79 ? 29.176 7.975 30.246 1.00 34.60 ? 95 ARG A NH2 1 ATOM 651 N N . GLN A 1 80 ? 26.485 15.284 31.854 1.00 34.94 ? 96 GLN A N 1 ATOM 652 C CA . GLN A 1 80 ? 25.772 15.907 30.735 1.00 35.25 ? 96 GLN A CA 1 ATOM 653 C C . GLN A 1 80 ? 26.499 17.131 30.180 1.00 35.43 ? 96 GLN A C 1 ATOM 654 O O . GLN A 1 80 ? 26.618 17.293 28.960 1.00 35.12 ? 96 GLN A O 1 ATOM 655 C CB . GLN A 1 80 ? 24.340 16.279 31.130 1.00 35.30 ? 96 GLN A CB 1 ATOM 656 C CG . GLN A 1 80 ? 23.410 15.094 31.316 1.00 35.92 ? 96 GLN A CG 1 ATOM 657 C CD . GLN A 1 80 ? 21.960 15.511 31.470 1.00 36.83 ? 96 GLN A CD 1 ATOM 658 O OE1 . GLN A 1 80 ? 21.395 16.183 30.599 1.00 37.18 ? 96 GLN A OE1 1 ATOM 659 N NE2 . GLN A 1 80 ? 21.351 15.120 32.581 1.00 36.66 ? 96 GLN A NE2 1 ATOM 660 N N . PHE A 1 81 ? 26.980 17.995 31.071 1.00 35.66 ? 97 PHE A N 1 ATOM 661 C CA . PHE A 1 81 ? 27.744 19.165 30.641 1.00 36.38 ? 97 PHE A CA 1 ATOM 662 C C . PHE A 1 81 ? 29.042 18.780 29.929 1.00 36.88 ? 97 PHE A C 1 ATOM 663 O O . PHE A 1 81 ? 29.392 19.371 28.903 1.00 36.42 ? 97 PHE A O 1 ATOM 664 C CB . PHE A 1 81 ? 28.033 20.101 31.813 1.00 36.31 ? 97 PHE A CB 1 ATOM 665 C CG . PHE A 1 81 ? 27.007 21.174 31.992 1.00 36.31 ? 97 PHE A CG 1 ATOM 666 C CD1 . PHE A 1 81 ? 27.001 22.290 31.163 1.00 36.82 ? 97 PHE A CD1 1 ATOM 667 C CD2 . PHE A 1 81 ? 26.044 21.074 32.992 1.00 36.72 ? 97 PHE A CD2 1 ATOM 668 C CE1 . PHE A 1 81 ? 26.047 23.292 31.324 1.00 37.56 ? 97 PHE A CE1 1 ATOM 669 C CE2 . PHE A 1 81 ? 25.092 22.071 33.162 1.00 36.88 ? 97 PHE A CE2 1 ATOM 670 C CZ . PHE A 1 81 ? 25.095 23.183 32.325 1.00 36.97 ? 97 PHE A CZ 1 ATOM 671 N N . LYS A 1 82 ? 29.741 17.781 30.464 1.00 37.68 ? 98 LYS A N 1 ATOM 672 C CA . LYS A 1 82 ? 30.975 17.306 29.833 1.00 38.79 ? 98 LYS A CA 1 ATOM 673 C C . LYS A 1 82 ? 30.715 16.816 28.406 1.00 38.97 ? 98 LYS A C 1 ATOM 674 O O . LYS A 1 82 ? 31.501 17.099 27.500 1.00 39.35 ? 98 LYS A O 1 ATOM 675 C CB . LYS A 1 82 ? 31.652 16.223 30.673 1.00 38.81 ? 98 LYS A CB 1 ATOM 676 C CG . LYS A 1 82 ? 33.130 16.050 30.360 1.00 40.42 ? 98 LYS A CG 1 ATOM 677 C CD . LYS A 1 82 ? 33.777 15.099 31.340 1.00 42.93 ? 98 LYS A CD 1 ATOM 678 C CE . LYS A 1 82 ? 35.133 14.633 30.857 1.00 44.31 ? 98 LYS A CE 1 ATOM 679 N NZ . LYS A 1 82 ? 35.549 13.420 31.627 1.00 46.17 ? 98 LYS A NZ 1 ATOM 680 N N . ALA A 1 83 ? 29.607 16.103 28.208 1.00 39.44 ? 99 ALA A N 1 ATOM 681 C CA . ALA A 1 83 ? 29.218 15.641 26.871 1.00 40.11 ? 99 ALA A CA 1 ATOM 682 C C . ALA A 1 83 ? 29.014 16.814 25.910 1.00 40.37 ? 99 ALA A C 1 ATOM 683 O O . ALA A 1 83 ? 29.404 16.739 24.746 1.00 40.65 ? 99 ALA A O 1 ATOM 684 C CB . ALA A 1 83 ? 27.970 14.786 26.944 1.00 40.03 ? 99 ALA A CB 1 ATOM 685 N N . LEU A 1 84 ? 28.429 17.900 26.412 1.00 40.68 ? 100 LEU A N 1 ATOM 686 C CA . LEU A 1 84 ? 28.183 19.103 25.614 1.00 41.14 ? 100 LEU A CA 1 ATOM 687 C C . LEU A 1 84 ? 29.444 19.878 25.207 1.00 41.62 ? 100 LEU A C 1 ATOM 688 O O . LEU A 1 84 ? 29.409 20.649 24.245 1.00 41.74 ? 100 LEU A O 1 ATOM 689 C CB . LEU A 1 84 ? 27.201 20.037 26.330 1.00 40.92 ? 100 LEU A CB 1 ATOM 690 C CG . LEU A 1 84 ? 25.760 19.547 26.480 1.00 40.86 ? 100 LEU A CG 1 ATOM 691 C CD1 . LEU A 1 84 ? 24.968 20.517 27.338 1.00 40.82 ? 100 LEU A CD1 1 ATOM 692 C CD2 . LEU A 1 84 ? 25.099 19.356 25.125 1.00 39.96 ? 100 LEU A CD2 1 ATOM 693 N N . THR A 1 85 ? 30.547 19.682 25.931 1.00 41.95 ? 101 THR A N 1 ATOM 694 C CA . THR A 1 85 ? 31.819 20.334 25.578 1.00 42.37 ? 101 THR A CA 1 ATOM 695 C C . THR A 1 85 ? 32.490 19.659 24.387 1.00 42.43 ? 101 THR A C 1 ATOM 696 O O . THR A 1 85 ? 33.355 20.249 23.739 1.00 42.75 ? 101 THR A O 1 ATOM 697 C CB . THR A 1 85 ? 32.835 20.347 26.751 1.00 42.27 ? 101 THR A CB 1 ATOM 698 O OG1 . THR A 1 85 ? 33.257 19.007 27.041 1.00 42.93 ? 101 THR A OG1 1 ATOM 699 C CG2 . THR A 1 85 ? 32.233 20.982 27.997 1.00 42.19 ? 101 THR A CG2 1 ATOM 700 N N . LYS A 1 86 ? 32.094 18.422 24.105 1.00 42.44 ? 102 LYS A N 1 ATOM 701 C CA . LYS A 1 86 ? 32.759 17.626 23.079 1.00 42.49 ? 102 LYS A CA 1 ATOM 702 C C . LYS A 1 86 ? 32.252 17.948 21.675 1.00 41.99 ? 102 LYS A C 1 ATOM 703 O O . LYS A 1 86 ? 31.291 17.350 21.194 1.00 42.45 ? 102 LYS A O 1 ATOM 704 C CB . LYS A 1 86 ? 32.679 16.134 23.416 1.00 42.78 ? 102 LYS A CB 1 ATOM 705 C CG . LYS A 1 86 ? 33.670 15.755 24.520 1.00 44.07 ? 102 LYS A CG 1 ATOM 706 C CD . LYS A 1 86 ? 33.354 14.434 25.193 1.00 46.16 ? 102 LYS A CD 1 ATOM 707 C CE . LYS A 1 86 ? 34.147 14.316 26.498 1.00 46.76 ? 102 LYS A CE 1 ATOM 708 N NZ . LYS A 1 86 ? 34.065 12.956 27.096 1.00 47.48 ? 102 LYS A NZ 1 ATOM 709 N N . LEU A 1 87 ? 32.927 18.897 21.033 1.00 41.27 ? 103 LEU A N 1 ATOM 710 C CA . LEU A 1 87 ? 32.539 19.415 19.716 1.00 40.60 ? 103 LEU A CA 1 ATOM 711 C C . LEU A 1 87 ? 32.848 18.498 18.540 1.00 39.99 ? 103 LEU A C 1 ATOM 712 O O . LEU A 1 87 ? 32.119 18.499 17.544 1.00 39.98 ? 103 LEU A O 1 ATOM 713 C CB . LEU A 1 87 ? 33.216 20.764 19.461 1.00 40.51 ? 103 LEU A CB 1 ATOM 714 C CG . LEU A 1 87 ? 32.557 22.013 20.041 1.00 41.11 ? 103 LEU A CG 1 ATOM 715 C CD1 . LEU A 1 87 ? 33.403 23.245 19.741 1.00 41.45 ? 103 LEU A CD1 1 ATOM 716 C CD2 . LEU A 1 87 ? 31.137 22.194 19.512 1.00 40.91 ? 103 LEU A CD2 1 ATOM 717 N N . GLY A 1 88 ? 33.939 17.741 18.640 1.00 39.00 ? 104 GLY A N 1 ATOM 718 C CA . GLY A 1 88 ? 34.420 16.949 17.516 1.00 37.91 ? 104 GLY A CA 1 ATOM 719 C C . GLY A 1 88 ? 34.706 17.840 16.319 1.00 37.20 ? 104 GLY A C 1 ATOM 720 O O . GLY A 1 88 ? 35.312 18.907 16.458 1.00 36.79 ? 104 GLY A O 1 ATOM 721 N N . TYR A 1 89 ? 34.244 17.418 15.146 1.00 36.47 ? 105 TYR A N 1 ATOM 722 C CA . TYR A 1 89 ? 34.479 18.166 13.905 1.00 36.25 ? 105 TYR A CA 1 ATOM 723 C C . TYR A 1 89 ? 33.898 19.582 13.934 1.00 36.06 ? 105 TYR A C 1 ATOM 724 O O . TYR A 1 89 ? 34.419 20.481 13.279 1.00 36.00 ? 105 TYR A O 1 ATOM 725 C CB . TYR A 1 89 ? 33.921 17.411 12.696 1.00 36.01 ? 105 TYR A CB 1 ATOM 726 C CG . TYR A 1 89 ? 34.615 16.102 12.375 1.00 36.05 ? 105 TYR A CG 1 ATOM 727 C CD1 . TYR A 1 89 ? 35.912 15.831 12.837 1.00 35.52 ? 105 TYR A CD1 1 ATOM 728 C CD2 . TYR A 1 89 ? 33.990 15.150 11.572 1.00 35.30 ? 105 TYR A CD2 1 ATOM 729 C CE1 . TYR A 1 89 ? 36.549 14.628 12.529 1.00 35.48 ? 105 TYR A CE1 1 ATOM 730 C CE2 . TYR A 1 89 ? 34.620 13.951 11.251 1.00 35.50 ? 105 TYR A CE2 1 ATOM 731 C CZ . TYR A 1 89 ? 35.895 13.697 11.728 1.00 35.23 ? 105 TYR A CZ 1 ATOM 732 O OH . TYR A 1 89 ? 36.511 12.510 11.408 1.00 34.98 ? 105 TYR A OH 1 ATOM 733 N N . ALA A 1 90 ? 32.829 19.766 14.703 1.00 35.96 ? 106 ALA A N 1 ATOM 734 C CA . ALA A 1 90 ? 32.165 21.061 14.842 1.00 36.27 ? 106 ALA A CA 1 ATOM 735 C C . ALA A 1 90 ? 33.057 22.159 15.446 1.00 36.47 ? 106 ALA A C 1 ATOM 736 O O . ALA A 1 90 ? 32.699 23.338 15.400 1.00 36.73 ? 106 ALA A O 1 ATOM 737 C CB . ALA A 1 90 ? 30.875 20.908 15.648 1.00 36.22 ? 106 ALA A CB 1 ATOM 738 N N . ALA A 1 91 ? 34.206 21.771 16.004 1.00 36.54 ? 107 ALA A N 1 ATOM 739 C CA . ALA A 1 91 ? 35.195 22.731 16.513 1.00 36.59 ? 107 ALA A CA 1 ATOM 740 C C . ALA A 1 91 ? 35.904 23.493 15.394 1.00 36.80 ? 107 ALA A C 1 ATOM 741 O O . ALA A 1 91 ? 36.401 24.603 15.613 1.00 36.55 ? 107 ALA A O 1 ATOM 742 C CB . ALA A 1 91 ? 36.219 22.035 17.408 1.00 36.43 ? 107 ALA A CB 1 ATOM 743 N N . LEU A 1 92 ? 35.949 22.894 14.201 1.00 36.88 ? 108 LEU A N 1 ATOM 744 C CA . LEU A 1 92 ? 36.634 23.485 13.051 1.00 37.11 ? 108 LEU A CA 1 ATOM 745 C C . LEU A 1 92 ? 36.046 24.838 12.652 1.00 37.55 ? 108 LEU A C 1 ATOM 746 O O . LEU A 1 92 ? 34.850 25.067 12.825 1.00 37.54 ? 108 LEU A O 1 ATOM 747 C CB . LEU A 1 92 ? 36.588 22.538 11.845 1.00 37.05 ? 108 LEU A CB 1 ATOM 748 C CG . LEU A 1 92 ? 37.464 21.282 11.853 1.00 36.67 ? 108 LEU A CG 1 ATOM 749 C CD1 . LEU A 1 92 ? 37.017 20.334 10.758 1.00 36.59 ? 108 LEU A CD1 1 ATOM 750 C CD2 . LEU A 1 92 ? 38.940 21.622 11.690 1.00 35.64 ? 108 LEU A CD2 1 ATOM 751 N N . PRO A 1 93 ? 36.885 25.742 12.115 1.00 38.05 ? 109 PRO A N 1 ATOM 752 C CA . PRO A 1 93 ? 36.326 26.956 11.535 1.00 38.50 ? 109 PRO A CA 1 ATOM 753 C C . PRO A 1 93 ? 35.343 26.624 10.412 1.00 38.86 ? 109 PRO A C 1 ATOM 754 O O . PRO A 1 93 ? 35.483 25.593 9.750 1.00 38.66 ? 109 PRO A O 1 ATOM 755 C CB . PRO A 1 93 ? 37.553 27.679 10.974 1.00 38.68 ? 109 PRO A CB 1 ATOM 756 C CG . PRO A 1 93 ? 38.693 27.172 11.788 1.00 38.74 ? 109 PRO A CG 1 ATOM 757 C CD . PRO A 1 93 ? 38.360 25.742 12.084 1.00 38.11 ? 109 PRO A CD 1 ATOM 758 N N . GLU A 1 94 ? 34.358 27.502 10.233 1.00 39.26 ? 110 GLU A N 1 ATOM 759 C CA . GLU A 1 94 ? 33.270 27.348 9.268 1.00 39.67 ? 110 GLU A CA 1 ATOM 760 C C . GLU A 1 94 ? 33.708 26.763 7.929 1.00 39.99 ? 110 GLU A C 1 ATOM 761 O O . GLU A 1 94 ? 33.139 25.771 7.468 1.00 40.35 ? 110 GLU A O 1 ATOM 762 C CB . GLU A 1 94 ? 32.579 28.701 9.064 0.50 39.58 ? 110 GLU A CB 1 ATOM 763 C CG . GLU A 1 94 ? 31.421 28.701 8.089 0.50 39.41 ? 110 GLU A CG 1 ATOM 764 C CD . GLU A 1 94 ? 30.688 30.025 8.086 0.50 39.20 ? 110 GLU A CD 1 ATOM 765 O OE1 . GLU A 1 94 ? 30.325 30.504 9.180 0.50 38.83 ? 110 GLU A OE1 1 ATOM 766 O OE2 . GLU A 1 94 ? 30.489 30.592 6.994 0.50 38.86 ? 110 GLU A OE2 1 ATOM 767 N N . ASP A 1 95 ? 34.717 27.375 7.316 1.00 40.40 ? 111 ASP A N 1 ATOM 768 C CA . ASP A 1 95 ? 35.204 26.946 6.004 1.00 41.01 ? 111 ASP A CA 1 ATOM 769 C C . ASP A 1 95 ? 35.867 25.568 6.044 1.00 40.73 ? 111 ASP A C 1 ATOM 770 O O . ASP A 1 95 ? 35.734 24.787 5.102 1.00 40.77 ? 111 ASP A O 1 ATOM 771 C CB . ASP A 1 95 ? 36.170 27.980 5.418 1.00 41.30 ? 111 ASP A CB 1 ATOM 772 C CG . ASP A 1 95 ? 35.463 29.236 4.924 1.00 43.14 ? 111 ASP A CG 1 ATOM 773 O OD1 . ASP A 1 95 ? 34.215 29.313 5.000 1.00 45.19 ? 111 ASP A OD1 1 ATOM 774 O OD2 . ASP A 1 95 ? 36.167 30.156 4.455 1.00 45.38 ? 111 ASP A OD2 1 ATOM 775 N N . ASP A 1 96 ? 36.573 25.281 7.136 1.00 40.45 ? 112 ASP A N 1 ATOM 776 C CA . ASP A 1 96 ? 37.239 23.989 7.315 1.00 40.21 ? 112 ASP A CA 1 ATOM 777 C C . ASP A 1 96 ? 36.239 22.863 7.503 1.00 39.76 ? 112 ASP A C 1 ATOM 778 O O . ASP A 1 96 ? 36.447 21.755 7.008 1.00 39.75 ? 112 ASP A O 1 ATOM 779 C CB . ASP A 1 96 ? 38.197 24.028 8.507 1.00 40.32 ? 112 ASP A CB 1 ATOM 780 C CG . ASP A 1 96 ? 39.453 24.813 8.220 1.00 40.68 ? 112 ASP A CG 1 ATOM 781 O OD1 . ASP A 1 96 ? 39.779 25.031 7.032 1.00 40.90 ? 112 ASP A OD1 1 ATOM 782 O OD2 . ASP A 1 96 ? 40.126 25.205 9.192 1.00 41.16 ? 112 ASP A OD2 1 ATOM 783 N N . TYR A 1 97 ? 35.163 23.150 8.230 1.00 39.39 ? 113 TYR A N 1 ATOM 784 C CA . TYR A 1 97 ? 34.090 22.186 8.424 1.00 39.09 ? 113 TYR A CA 1 ATOM 785 C C . TYR A 1 97 ? 33.388 21.849 7.103 1.00 39.06 ? 113 TYR A C 1 ATOM 786 O O . TYR A 1 97 ? 33.092 20.681 6.838 1.00 38.78 ? 113 TYR A O 1 ATOM 787 C CB . TYR A 1 97 ? 33.079 22.682 9.462 1.00 38.84 ? 113 TYR A CB 1 ATOM 788 C CG . TYR A 1 97 ? 32.063 21.629 9.827 1.00 39.09 ? 113 TYR A CG 1 ATOM 789 C CD1 . TYR A 1 97 ? 32.371 20.626 10.748 1.00 38.93 ? 113 TYR A CD1 1 ATOM 790 C CD2 . TYR A 1 97 ? 30.800 21.616 9.233 1.00 38.53 ? 113 TYR A CD2 1 ATOM 791 C CE1 . TYR A 1 97 ? 31.441 19.640 11.075 1.00 39.06 ? 113 TYR A CE1 1 ATOM 792 C CE2 . TYR A 1 97 ? 29.864 20.640 9.556 1.00 38.42 ? 113 TYR A CE2 1 ATOM 793 C CZ . TYR A 1 97 ? 30.188 19.654 10.475 1.00 38.40 ? 113 TYR A CZ 1 ATOM 794 O OH . TYR A 1 97 ? 29.262 18.689 10.793 1.00 36.76 ? 113 TYR A OH 1 ATOM 795 N N . ALA A 1 98 ? 33.123 22.868 6.285 1.00 38.98 ? 114 ALA A N 1 ATOM 796 C CA . ALA A 1 98 ? 32.494 22.654 4.975 1.00 39.17 ? 114 ALA A CA 1 ATOM 797 C C . ALA A 1 98 ? 33.369 21.771 4.092 1.00 39.01 ? 114 ALA A C 1 ATOM 798 O O . ALA A 1 98 ? 32.877 20.827 3.476 1.00 39.30 ? 114 ALA A O 1 ATOM 799 C CB . ALA A 1 98 ? 32.197 23.983 4.283 1.00 38.92 ? 114 ALA A CB 1 ATOM 800 N N . GLU A 1 99 ? 34.667 22.074 4.059 1.00 39.14 ? 115 GLU A N 1 ATOM 801 C CA . GLU A 1 99 ? 35.637 21.315 3.267 1.00 39.05 ? 115 GLU A CA 1 ATOM 802 C C . GLU A 1 99 ? 35.744 19.858 3.725 1.00 38.98 ? 115 GLU A C 1 ATOM 803 O O . GLU A 1 99 ? 35.843 18.951 2.892 1.00 38.94 ? 115 GLU A O 1 ATOM 804 C CB . GLU A 1 99 ? 37.015 21.983 3.298 1.00 39.18 ? 115 GLU A CB 1 ATOM 805 C CG . GLU A 1 99 ? 38.014 21.364 2.315 1.00 39.53 ? 115 GLU A CG 1 ATOM 806 C CD . GLU A 1 99 ? 39.396 21.984 2.381 1.00 40.56 ? 115 GLU A CD 1 ATOM 807 O OE1 . GLU A 1 99 ? 39.590 22.961 3.135 1.00 41.94 ? 115 GLU A OE1 1 ATOM 808 O OE2 . GLU A 1 99 ? 40.298 21.487 1.674 1.00 40.90 ? 115 GLU A OE2 1 ATOM 809 N N . LEU A 1 100 ? 35.717 19.637 5.040 1.00 38.51 ? 116 LEU A N 1 ATOM 810 C CA . LEU A 1 100 ? 35.741 18.280 5.575 1.00 38.25 ? 116 LEU A CA 1 ATOM 811 C C . LEU A 1 100 ? 34.517 17.486 5.121 1.00 38.16 ? 116 LEU A C 1 ATOM 812 O O . LEU A 1 100 ? 34.652 16.360 4.652 1.00 38.07 ? 116 LEU A O 1 ATOM 813 C CB . LEU A 1 100 ? 35.858 18.280 7.106 1.00 38.10 ? 116 LEU A CB 1 ATOM 814 C CG . LEU A 1 100 ? 35.871 16.908 7.794 1.00 37.80 ? 116 LEU A CG 1 ATOM 815 C CD1 . LEU A 1 100 ? 36.924 15.974 7.198 1.00 36.85 ? 116 LEU A CD1 1 ATOM 816 C CD2 . LEU A 1 100 ? 36.086 17.070 9.286 1.00 37.68 ? 116 LEU A CD2 1 ATOM 817 N N . LEU A 1 101 ? 33.332 18.076 5.253 1.00 38.29 ? 117 LEU A N 1 ATOM 818 C CA . LEU A 1 101 ? 32.102 17.412 4.835 1.00 38.47 ? 117 LEU A CA 1 ATOM 819 C C . LEU A 1 101 ? 32.099 17.103 3.336 1.00 38.51 ? 117 LEU A C 1 ATOM 820 O O . LEU A 1 101 ? 31.635 16.037 2.923 1.00 38.46 ? 117 LEU A O 1 ATOM 821 C CB . LEU A 1 101 ? 30.877 18.249 5.198 1.00 38.79 ? 117 LEU A CB 1 ATOM 822 C CG . LEU A 1 101 ? 30.458 18.424 6.659 1.00 39.19 ? 117 LEU A CG 1 ATOM 823 C CD1 . LEU A 1 101 ? 29.111 19.106 6.673 1.00 40.30 ? 117 LEU A CD1 1 ATOM 824 C CD2 . LEU A 1 101 ? 30.387 17.109 7.421 1.00 39.87 ? 117 LEU A CD2 1 ATOM 825 N N . ASP A 1 102 ? 32.618 18.029 2.531 1.00 38.54 ? 118 ASP A N 1 ATOM 826 C CA . ASP A 1 102 ? 32.733 17.810 1.087 1.00 38.98 ? 118 ASP A CA 1 ATOM 827 C C . ASP A 1 102 ? 33.705 16.673 0.794 1.00 38.57 ? 118 ASP A C 1 ATOM 828 O O . ASP A 1 102 ? 33.473 15.867 -0.107 1.00 38.60 ? 118 ASP A O 1 ATOM 829 C CB . ASP A 1 102 ? 33.179 19.083 0.362 1.00 39.44 ? 118 ASP A CB 1 ATOM 830 C CG . ASP A 1 102 ? 32.047 20.091 0.178 1.00 41.01 ? 118 ASP A CG 1 ATOM 831 O OD1 . ASP A 1 102 ? 30.854 19.714 0.242 1.00 43.32 ? 118 ASP A OD1 1 ATOM 832 O OD2 . ASP A 1 102 ? 32.357 21.278 -0.042 1.00 43.66 ? 118 ASP A OD2 1 ATOM 833 N N . THR A 1 103 ? 34.785 16.615 1.571 1.00 38.17 ? 119 THR A N 1 ATOM 834 C CA . THR A 1 103 ? 35.782 15.550 1.461 1.00 37.57 ? 119 THR A CA 1 ATOM 835 C C . THR A 1 103 ? 35.191 14.177 1.811 1.00 37.07 ? 119 THR A C 1 ATOM 836 O O . THR A 1 103 ? 35.440 13.195 1.107 1.00 36.73 ? 119 THR A O 1 ATOM 837 C CB . THR A 1 103 ? 37.007 15.852 2.353 1.00 37.65 ? 119 THR A CB 1 ATOM 838 O OG1 . THR A 1 103 ? 37.515 17.153 2.033 1.00 37.88 ? 119 THR A OG1 1 ATOM 839 C CG2 . THR A 1 103 ? 38.102 14.831 2.144 1.00 37.33 ? 119 THR A CG2 1 ATOM 840 N N . LEU A 1 104 ? 34.406 14.123 2.889 1.00 36.62 ? 120 LEU A N 1 ATOM 841 C CA . LEU A 1 104 ? 33.772 12.880 3.344 1.00 36.31 ? 120 LEU A CA 1 ATOM 842 C C . LEU A 1 104 ? 32.757 12.327 2.335 1.00 36.38 ? 120 LEU A C 1 ATOM 843 O O . LEU A 1 104 ? 32.731 11.118 2.068 1.00 36.17 ? 120 LEU A O 1 ATOM 844 C CB . LEU A 1 104 ? 33.121 13.059 4.730 1.00 36.02 ? 120 LEU A CB 1 ATOM 845 C CG . LEU A 1 104 ? 34.047 13.346 5.925 1.00 35.89 ? 120 LEU A CG 1 ATOM 846 C CD1 . LEU A 1 104 ? 33.245 13.574 7.207 1.00 35.85 ? 120 LEU A CD1 1 ATOM 847 C CD2 . LEU A 1 104 ? 35.076 12.236 6.132 1.00 35.12 ? 120 LEU A CD2 1 ATOM 848 N N . SER A 1 105 ? 31.920 13.200 1.777 1.00 36.28 ? 121 SER A N 1 ATOM 849 C CA . SER A 1 105 ? 30.944 12.740 0.787 1.00 36.52 ? 121 SER A CA 1 ATOM 850 C C . SER A 1 105 ? 31.599 12.332 -0.544 1.00 36.19 ? 121 SER A C 1 ATOM 851 O O . SER A 1 105 ? 31.126 11.415 -1.206 1.00 36.40 ? 121 SER A O 1 ATOM 852 C CB . SER A 1 105 ? 29.775 13.720 0.605 1.00 36.38 ? 121 SER A CB 1 ATOM 853 O OG . SER A 1 105 ? 30.203 15.065 0.597 1.00 37.53 ? 121 SER A OG 1 ATOM 854 N N . ALA A 1 106 ? 32.693 12.992 -0.913 1.00 36.30 ? 122 ALA A N 1 ATOM 855 C CA . ALA A 1 106 ? 33.471 12.581 -2.088 1.00 36.37 ? 122 ALA A CA 1 ATOM 856 C C . ALA A 1 106 ? 33.954 11.134 -1.938 1.00 36.53 ? 122 ALA A C 1 ATOM 857 O O . ALA A 1 106 ? 33.860 10.341 -2.875 1.00 36.33 ? 122 ALA A O 1 ATOM 858 C CB . ALA A 1 106 ? 34.644 13.515 -2.316 1.00 36.27 ? 122 ALA A CB 1 ATOM 859 N N . MET A 1 107 ? 34.442 10.789 -0.746 1.00 36.41 ? 123 MET A N 1 ATOM 860 C CA . MET A 1 107 ? 34.931 9.435 -0.478 1.00 36.67 ? 123 MET A CA 1 ATOM 861 C C . MET A 1 107 ? 33.807 8.403 -0.393 1.00 36.65 ? 123 MET A C 1 ATOM 862 O O . MET A 1 107 ? 33.893 7.349 -1.024 1.00 36.54 ? 123 MET A O 1 ATOM 863 C CB . MET A 1 107 ? 35.813 9.391 0.783 1.00 36.65 ? 123 MET A CB 1 ATOM 864 C CG . MET A 1 107 ? 37.127 10.136 0.643 1.00 37.12 ? 123 MET A CG 1 ATOM 865 S SD . MET A 1 107 ? 38.297 9.821 1.976 1.00 39.08 ? 123 MET A SD 1 ATOM 866 C CE . MET A 1 107 ? 37.408 10.467 3.390 1.00 36.74 ? 123 MET A CE 1 ATOM 867 N N . GLU A 1 108 ? 32.759 8.698 0.376 1.00 36.78 ? 124 GLU A N 1 ATOM 868 C CA . GLU A 1 108 ? 31.639 7.762 0.507 1.00 37.06 ? 124 GLU A CA 1 ATOM 869 C C . GLU A 1 108 ? 30.913 7.528 -0.819 1.00 36.73 ? 124 GLU A C 1 ATOM 870 O O . GLU A 1 108 ? 30.515 6.401 -1.111 1.00 36.41 ? 124 GLU A O 1 ATOM 871 C CB . GLU A 1 108 ? 30.640 8.205 1.578 1.00 37.38 ? 124 GLU A CB 1 ATOM 872 C CG . GLU A 1 108 ? 29.513 7.187 1.808 1.00 39.13 ? 124 GLU A CG 1 ATOM 873 C CD . GLU A 1 108 ? 28.756 7.393 3.113 1.00 41.68 ? 124 GLU A CD 1 ATOM 874 O OE1 . GLU A 1 108 ? 28.649 8.543 3.589 1.00 43.77 ? 124 GLU A OE1 1 ATOM 875 O OE2 . GLU A 1 108 ? 28.254 6.394 3.662 1.00 42.84 ? 124 GLU A OE2 1 ATOM 876 N N . SER A 1 109 ? 30.737 8.585 -1.609 1.00 36.47 ? 125 SER A N 1 ATOM 877 C CA . SER A 1 109 ? 30.056 8.447 -2.902 1.00 36.51 ? 125 SER A CA 1 ATOM 878 C C . SER A 1 109 ? 30.922 7.726 -3.939 1.00 36.07 ? 125 SER A C 1 ATOM 879 O O . SER A 1 109 ? 30.399 6.974 -4.762 1.00 36.28 ? 125 SER A O 1 ATOM 880 C CB . SER A 1 109 ? 29.541 9.791 -3.429 1.00 36.32 ? 125 SER A CB 1 ATOM 881 O OG . SER A 1 109 ? 30.606 10.646 -3.792 1.00 37.38 ? 125 SER A OG 1 ATOM 882 N N . ASN A 1 110 ? 32.236 7.951 -3.898 1.00 35.89 ? 126 ASN A N 1 ATOM 883 C CA . ASN A 1 110 ? 33.167 7.178 -4.729 1.00 35.85 ? 126 ASN A CA 1 ATOM 884 C C . ASN A 1 110 ? 33.013 5.685 -4.462 1.00 35.79 ? 126 ASN A C 1 ATOM 885 O O . ASN A 1 110 ? 32.847 4.890 -5.394 1.00 35.68 ? 126 ASN A O 1 ATOM 886 C CB . ASN A 1 110 ? 34.622 7.597 -4.497 1.00 35.83 ? 126 ASN A CB 1 ATOM 887 C CG . ASN A 1 110 ? 35.607 6.796 -5.349 1.00 36.17 ? 126 ASN A CG 1 ATOM 888 O OD1 . ASN A 1 110 ? 35.902 7.162 -6.488 1.00 36.55 ? 126 ASN A OD1 1 ATOM 889 N ND2 . ASN A 1 110 ? 36.124 5.702 -4.793 1.00 34.67 ? 126 ASN A ND2 1 ATOM 890 N N . PHE A 1 111 ? 33.055 5.320 -3.181 1.00 35.18 ? 127 PHE A N 1 ATOM 891 C CA . PHE A 1 111 ? 32.881 3.942 -2.763 1.00 34.89 ? 127 PHE A CA 1 ATOM 892 C C . PHE A 1 111 ? 31.560 3.362 -3.259 1.00 35.16 ? 127 PHE A C 1 ATOM 893 O O . PHE A 1 111 ? 31.520 2.251 -3.788 1.00 35.00 ? 127 PHE A O 1 ATOM 894 C CB . PHE A 1 111 ? 32.935 3.833 -1.232 1.00 34.43 ? 127 PHE A CB 1 ATOM 895 C CG . PHE A 1 111 ? 32.885 2.423 -0.735 1.00 33.23 ? 127 PHE A CG 1 ATOM 896 C CD1 . PHE A 1 111 ? 31.664 1.772 -0.566 1.00 32.59 ? 127 PHE A CD1 1 ATOM 897 C CD2 . PHE A 1 111 ? 34.061 1.733 -0.455 1.00 32.90 ? 127 PHE A CD2 1 ATOM 898 C CE1 . PHE A 1 111 ? 31.610 0.454 -0.121 1.00 33.29 ? 127 PHE A CE1 1 ATOM 899 C CE2 . PHE A 1 111 ? 34.022 0.410 -0.005 1.00 33.68 ? 127 PHE A CE2 1 ATOM 900 C CZ . PHE A 1 111 ? 32.794 -0.229 0.165 1.00 33.48 ? 127 PHE A CZ 1 ATOM 901 N N . ALA A 1 112 ? 30.481 4.117 -3.061 1.00 35.43 ? 128 ALA A N 1 ATOM 902 C CA . ALA A 1 112 ? 29.142 3.659 -3.395 1.00 35.96 ? 128 ALA A CA 1 ATOM 903 C C . ALA A 1 112 ? 28.906 3.576 -4.907 1.00 36.42 ? 128 ALA A C 1 ATOM 904 O O . ALA A 1 112 ? 28.034 2.833 -5.353 1.00 36.70 ? 128 ALA A O 1 ATOM 905 C CB . ALA A 1 112 ? 28.107 4.553 -2.744 1.00 35.94 ? 128 ALA A CB 1 ATOM 906 N N . LYS A 1 113 ? 29.677 4.331 -5.684 1.00 36.75 ? 129 LYS A N 1 ATOM 907 C CA . LYS A 1 113 ? 29.490 4.362 -7.140 1.00 37.73 ? 129 LYS A CA 1 ATOM 908 C C . LYS A 1 113 ? 30.411 3.418 -7.914 1.00 38.02 ? 129 LYS A C 1 ATOM 909 O O . LYS A 1 113 ? 30.362 3.382 -9.143 1.00 38.53 ? 129 LYS A O 1 ATOM 910 C CB . LYS A 1 113 ? 29.630 5.789 -7.678 1.00 37.53 ? 129 LYS A CB 1 ATOM 911 C CG . LYS A 1 113 ? 28.407 6.663 -7.439 1.00 38.65 ? 129 LYS A CG 1 ATOM 912 C CD . LYS A 1 113 ? 28.697 8.102 -7.828 1.00 40.71 ? 129 LYS A CD 1 ATOM 913 C CE . LYS A 1 113 ? 27.458 8.961 -7.720 1.00 42.37 ? 129 LYS A CE 1 ATOM 914 N NZ . LYS A 1 113 ? 27.798 10.410 -7.829 1.00 43.78 ? 129 LYS A NZ 1 ATOM 915 N N . VAL A 1 114 ? 31.246 2.660 -7.204 1.00 38.49 ? 130 VAL A N 1 ATOM 916 C CA . VAL A 1 114 ? 32.173 1.725 -7.849 1.00 38.63 ? 130 VAL A CA 1 ATOM 917 C C . VAL A 1 114 ? 31.444 0.674 -8.703 1.00 39.00 ? 130 VAL A C 1 ATOM 918 O O . VAL A 1 114 ? 30.569 -0.047 -8.217 1.00 38.75 ? 130 VAL A O 1 ATOM 919 C CB . VAL A 1 114 ? 33.116 1.024 -6.824 1.00 38.57 ? 130 VAL A CB 1 ATOM 920 C CG1 . VAL A 1 114 ? 33.974 -0.042 -7.506 1.00 38.08 ? 130 VAL A CG1 1 ATOM 921 C CG2 . VAL A 1 114 ? 34.009 2.044 -6.120 1.00 38.14 ? 130 VAL A CG2 1 ATOM 922 N N . LYS A 1 115 ? 31.818 0.616 -9.977 1.00 39.63 ? 131 LYS A N 1 ATOM 923 C CA . LYS A 1 115 ? 31.341 -0.412 -10.904 1.00 40.56 ? 131 LYS A CA 1 ATOM 924 C C . LYS A 1 115 ? 32.548 -0.974 -11.632 1.00 40.62 ? 131 LYS A C 1 ATOM 925 O O . LYS A 1 115 ? 33.455 -0.232 -11.990 1.00 40.70 ? 131 LYS A O 1 ATOM 926 C CB . LYS A 1 115 ? 30.353 0.173 -11.930 1.00 40.84 ? 131 LYS A CB 1 ATOM 927 C CG . LYS A 1 115 ? 29.054 0.756 -11.366 1.00 41.63 ? 131 LYS A CG 1 ATOM 928 C CD . LYS A 1 115 ? 28.107 -0.327 -10.869 1.00 43.92 ? 131 LYS A CD 1 ATOM 929 C CE . LYS A 1 115 ? 26.645 0.126 -10.906 1.00 45.14 ? 131 LYS A CE 1 ATOM 930 N NZ . LYS A 1 115 ? 26.348 1.232 -9.952 1.00 46.02 ? 131 LYS A NZ 1 ATOM 931 N N . VAL A 1 116 ? 32.569 -2.286 -11.836 1.00 41.36 ? 132 VAL A N 1 ATOM 932 C CA . VAL A 1 116 ? 33.668 -2.932 -12.557 1.00 42.00 ? 132 VAL A CA 1 ATOM 933 C C . VAL A 1 116 ? 33.145 -3.735 -13.747 1.00 42.76 ? 132 VAL A C 1 ATOM 934 O O . VAL A 1 116 ? 31.954 -4.035 -13.824 1.00 42.54 ? 132 VAL A O 1 ATOM 935 C CB . VAL A 1 116 ? 34.523 -3.851 -11.639 1.00 41.79 ? 132 VAL A CB 1 ATOM 936 C CG1 . VAL A 1 116 ? 35.012 -3.091 -10.404 1.00 41.78 ? 132 VAL A CG1 1 ATOM 937 C CG2 . VAL A 1 116 ? 33.747 -5.085 -11.236 1.00 41.56 ? 132 VAL A CG2 1 ATOM 938 N N . CYS A 1 117 ? 34.045 -4.086 -14.661 1.00 43.68 ? 133 CYS A N 1 ATOM 939 C CA . CYS A 1 117 ? 33.681 -4.889 -15.824 1.00 44.89 ? 133 CYS A CA 1 ATOM 940 C C . CYS A 1 117 ? 33.689 -6.380 -15.516 1.00 45.25 ? 133 CYS A C 1 ATOM 941 O O . CYS A 1 117 ? 34.524 -6.861 -14.745 1.00 45.14 ? 133 CYS A O 1 ATOM 942 C CB . CYS A 1 117 ? 34.603 -4.573 -16.999 1.00 44.99 ? 133 CYS A CB 1 ATOM 943 S SG . CYS A 1 117 ? 34.522 -2.842 -17.489 1.00 46.90 ? 133 CYS A SG 1 ATOM 944 N N . ASP A 1 118 ? 32.742 -7.099 -16.118 1.00 45.90 ? 134 ASP A N 1 ATOM 945 C CA . ASP A 1 118 ? 32.652 -8.550 -15.994 1.00 46.79 ? 134 ASP A CA 1 ATOM 946 C C . ASP A 1 118 ? 33.962 -9.187 -16.455 1.00 47.24 ? 134 ASP A C 1 ATOM 947 O O . ASP A 1 118 ? 34.521 -8.802 -17.489 1.00 47.30 ? 134 ASP A O 1 ATOM 948 C CB . ASP A 1 118 ? 31.470 -9.085 -16.817 1.00 46.92 ? 134 ASP A CB 1 ATOM 949 C CG . ASP A 1 118 ? 31.171 -10.558 -16.550 1.00 47.56 ? 134 ASP A CG 1 ATOM 950 O OD1 . ASP A 1 118 ? 32.091 -11.399 -16.609 1.00 49.02 ? 134 ASP A OD1 1 ATOM 951 O OD2 . ASP A 1 118 ? 29.997 -10.885 -16.288 1.00 48.81 ? 134 ASP A OD2 1 ATOM 952 N N . TYR A 1 119 ? 34.439 -10.154 -15.674 1.00 47.79 ? 135 TYR A N 1 ATOM 953 C CA . TYR A 1 119 ? 35.677 -10.882 -15.965 1.00 48.50 ? 135 TYR A CA 1 ATOM 954 C C . TYR A 1 119 ? 35.624 -11.604 -17.315 1.00 49.28 ? 135 TYR A C 1 ATOM 955 O O . TYR A 1 119 ? 36.637 -11.698 -18.006 1.00 49.19 ? 135 TYR A O 1 ATOM 956 C CB . TYR A 1 119 ? 35.964 -11.883 -14.843 1.00 48.09 ? 135 TYR A CB 1 ATOM 957 C CG . TYR A 1 119 ? 37.206 -12.736 -15.015 1.00 47.28 ? 135 TYR A CG 1 ATOM 958 C CD1 . TYR A 1 119 ? 38.470 -12.156 -15.135 1.00 46.76 ? 135 TYR A CD1 1 ATOM 959 C CD2 . TYR A 1 119 ? 37.117 -14.127 -15.025 1.00 46.73 ? 135 TYR A CD2 1 ATOM 960 C CE1 . TYR A 1 119 ? 39.615 -12.941 -15.275 1.00 46.89 ? 135 TYR A CE1 1 ATOM 961 C CE2 . TYR A 1 119 ? 38.252 -14.922 -15.163 1.00 47.04 ? 135 TYR A CE2 1 ATOM 962 C CZ . TYR A 1 119 ? 39.497 -14.323 -15.286 1.00 47.09 ? 135 TYR A CZ 1 ATOM 963 O OH . TYR A 1 119 ? 40.619 -15.108 -15.420 1.00 47.32 ? 135 TYR A OH 1 ATOM 964 N N . LYS A 1 120 ? 34.438 -12.102 -17.666 1.00 50.39 ? 136 LYS A N 1 ATOM 965 C CA . LYS A 1 120 ? 34.205 -12.833 -18.914 1.00 51.76 ? 136 LYS A CA 1 ATOM 966 C C . LYS A 1 120 ? 33.662 -11.938 -20.040 1.00 52.24 ? 136 LYS A C 1 ATOM 967 O O . LYS A 1 120 ? 33.680 -12.328 -21.211 1.00 52.46 ? 136 LYS A O 1 ATOM 968 C CB . LYS A 1 120 ? 33.223 -13.986 -18.675 1.00 51.95 ? 136 LYS A CB 1 ATOM 969 C CG . LYS A 1 120 ? 33.701 -15.069 -17.710 1.00 53.32 ? 136 LYS A CG 1 ATOM 970 C CD . LYS A 1 120 ? 32.555 -16.031 -17.372 1.00 55.15 ? 136 LYS A CD 1 ATOM 971 C CE . LYS A 1 120 ? 33.028 -17.231 -16.552 1.00 56.30 ? 136 LYS A CE 1 ATOM 972 N NZ . LYS A 1 120 ? 33.211 -16.911 -15.103 1.00 57.18 ? 136 LYS A NZ 1 ATOM 973 N N . ASP A 1 121 ? 33.179 -10.749 -19.682 1.00 52.78 ? 137 ASP A N 1 ATOM 974 C CA . ASP A 1 121 ? 32.538 -9.843 -20.636 1.00 53.20 ? 137 ASP A CA 1 ATOM 975 C C . ASP A 1 121 ? 32.971 -8.399 -20.394 1.00 53.42 ? 137 ASP A C 1 ATOM 976 O O . ASP A 1 121 ? 32.425 -7.708 -19.531 1.00 53.71 ? 137 ASP A O 1 ATOM 977 C CB . ASP A 1 121 ? 31.011 -9.975 -20.542 1.00 53.31 ? 137 ASP A CB 1 ATOM 978 C CG . ASP A 1 121 ? 30.276 -9.350 -21.734 1.00 53.78 ? 137 ASP A CG 1 ATOM 979 O OD1 . ASP A 1 121 ? 30.850 -8.501 -22.455 1.00 53.89 ? 137 ASP A OD1 1 ATOM 980 O OD2 . ASP A 1 121 ? 29.099 -9.712 -21.939 1.00 54.13 ? 137 ASP A OD2 1 ATOM 981 N N . SER A 1 122 ? 33.940 -7.943 -21.178 1.00 53.67 ? 138 SER A N 1 ATOM 982 C CA . SER A 1 122 ? 34.538 -6.620 -20.998 1.00 53.99 ? 138 SER A CA 1 ATOM 983 C C . SER A 1 122 ? 33.625 -5.456 -21.401 1.00 53.94 ? 138 SER A C 1 ATOM 984 O O . SER A 1 122 ? 33.998 -4.288 -21.246 1.00 54.23 ? 138 SER A O 1 ATOM 985 C CB . SER A 1 122 ? 35.867 -6.538 -21.751 1.00 54.05 ? 138 SER A CB 1 ATOM 986 O OG . SER A 1 122 ? 35.683 -6.833 -23.125 1.00 55.15 ? 138 SER A OG 1 ATOM 987 N N . THR A 1 123 ? 32.436 -5.771 -21.911 1.00 53.75 ? 139 THR A N 1 ATOM 988 C CA . THR A 1 123 ? 31.457 -4.743 -22.282 1.00 53.49 ? 139 THR A CA 1 ATOM 989 C C . THR A 1 123 ? 30.375 -4.574 -21.210 1.00 53.03 ? 139 THR A C 1 ATOM 990 O O . THR A 1 123 ? 29.705 -3.539 -21.156 1.00 53.02 ? 139 THR A O 1 ATOM 991 C CB . THR A 1 123 ? 30.793 -5.031 -23.656 1.00 53.55 ? 139 THR A CB 1 ATOM 992 O OG1 . THR A 1 123 ? 30.063 -6.263 -23.597 1.00 53.92 ? 139 THR A OG1 1 ATOM 993 C CG2 . THR A 1 123 ? 31.845 -5.111 -24.762 1.00 53.76 ? 139 THR A CG2 1 ATOM 994 N N . LYS A 1 124 ? 30.211 -5.595 -20.369 1.00 52.34 ? 140 LYS A N 1 ATOM 995 C CA . LYS A 1 124 ? 29.283 -5.533 -19.245 1.00 51.70 ? 140 LYS A CA 1 ATOM 996 C C . LYS A 1 124 ? 30.004 -4.962 -18.017 1.00 50.92 ? 140 LYS A C 1 ATOM 997 O O . LYS A 1 124 ? 30.663 -5.694 -17.272 1.00 50.66 ? 140 LYS A O 1 ATOM 998 C CB . LYS A 1 124 ? 28.694 -6.919 -18.956 1.00 51.80 ? 140 LYS A CB 1 ATOM 999 C CG . LYS A 1 124 ? 27.536 -6.901 -17.972 1.00 53.08 ? 140 LYS A CG 1 ATOM 1000 C CD . LYS A 1 124 ? 26.729 -8.191 -18.023 1.00 55.13 ? 140 LYS A CD 1 ATOM 1001 C CE . LYS A 1 124 ? 25.450 -8.076 -17.194 1.00 55.91 ? 140 LYS A CE 1 ATOM 1002 N NZ . LYS A 1 124 ? 25.724 -8.014 -15.729 1.00 56.15 ? 140 LYS A NZ 1 ATOM 1003 N N . CYS A 1 125 ? 29.876 -3.651 -17.820 1.00 49.99 ? 141 CYS A N 1 ATOM 1004 C CA . CYS A 1 125 ? 30.627 -2.945 -16.777 1.00 49.22 ? 141 CYS A CA 1 ATOM 1005 C C . CYS A 1 125 ? 29.738 -2.267 -15.727 1.00 48.30 ? 141 CYS A C 1 ATOM 1006 O O . CYS A 1 125 ? 29.981 -1.124 -15.325 1.00 48.17 ? 141 CYS A O 1 ATOM 1007 C CB . CYS A 1 125 ? 31.602 -1.947 -17.412 1.00 49.17 ? 141 CYS A CB 1 ATOM 1008 S SG . CYS A 1 125 ? 32.788 -2.717 -18.561 1.00 50.63 ? 141 CYS A SG 1 ATOM 1009 N N . ASP A 1 126 ? 28.721 -2.995 -15.272 1.00 47.32 ? 142 ASP A N 1 ATOM 1010 C CA . ASP A 1 126 ? 27.778 -2.480 -14.280 1.00 46.58 ? 142 ASP A CA 1 ATOM 1011 C C . ASP A 1 126 ? 27.738 -3.348 -13.012 1.00 45.46 ? 142 ASP A C 1 ATOM 1012 O O . ASP A 1 126 ? 26.706 -3.448 -12.343 1.00 45.33 ? 142 ASP A O 1 ATOM 1013 C CB . ASP A 1 126 ? 26.376 -2.335 -14.898 1.00 46.83 ? 142 ASP A CB 1 ATOM 1014 C CG . ASP A 1 126 ? 25.803 -3.660 -15.392 1.00 48.49 ? 142 ASP A CG 1 ATOM 1015 O OD1 . ASP A 1 126 ? 26.571 -4.638 -15.568 1.00 50.14 ? 142 ASP A OD1 1 ATOM 1016 O OD2 . ASP A 1 126 ? 24.570 -3.724 -15.609 1.00 50.26 ? 142 ASP A OD2 1 ATOM 1017 N N . LEU A 1 127 ? 28.865 -3.977 -12.694 1.00 44.08 ? 143 LEU A N 1 ATOM 1018 C CA . LEU A 1 127 ? 28.946 -4.861 -11.532 1.00 43.10 ? 143 LEU A CA 1 ATOM 1019 C C . LEU A 1 127 ? 29.333 -4.065 -10.289 1.00 41.97 ? 143 LEU A C 1 ATOM 1020 O O . LEU A 1 127 ? 30.420 -3.499 -10.227 1.00 41.77 ? 143 LEU A O 1 ATOM 1021 C CB . LEU A 1 127 ? 29.938 -6.007 -11.785 1.00 43.04 ? 143 LEU A CB 1 ATOM 1022 C CG . LEU A 1 127 ? 29.459 -7.201 -12.628 1.00 43.55 ? 143 LEU A CG 1 ATOM 1023 C CD1 . LEU A 1 127 ? 29.289 -6.848 -14.106 1.00 43.39 ? 143 LEU A CD1 1 ATOM 1024 C CD2 . LEU A 1 127 ? 30.428 -8.362 -12.476 1.00 43.89 ? 143 LEU A CD2 1 ATOM 1025 N N . ALA A 1 128 ? 28.422 -4.004 -9.321 1.00 41.00 ? 144 ALA A N 1 ATOM 1026 C CA . ALA A 1 128 ? 28.664 -3.298 -8.059 1.00 40.09 ? 144 ALA A CA 1 ATOM 1027 C C . ALA A 1 128 ? 29.192 -4.267 -7.009 1.00 39.35 ? 144 ALA A C 1 ATOM 1028 O O . ALA A 1 128 ? 28.973 -5.474 -7.113 1.00 39.33 ? 144 ALA A O 1 ATOM 1029 C CB . ALA A 1 128 ? 27.381 -2.631 -7.568 1.00 39.91 ? 144 ALA A CB 1 ATOM 1030 N N . LEU A 1 129 ? 29.882 -3.746 -5.997 1.00 38.62 ? 145 LEU A N 1 ATOM 1031 C CA . LEU A 1 129 ? 30.350 -4.590 -4.890 1.00 38.00 ? 145 LEU A CA 1 ATOM 1032 C C . LEU A 1 129 ? 29.198 -5.414 -4.315 1.00 37.86 ? 145 LEU A C 1 ATOM 1033 O O . LEU A 1 129 ? 29.293 -6.638 -4.192 1.00 37.54 ? 145 LEU A O 1 ATOM 1034 C CB . LEU A 1 129 ? 31.000 -3.747 -3.784 1.00 37.61 ? 145 LEU A CB 1 ATOM 1035 C CG . LEU A 1 129 ? 31.481 -4.487 -2.531 1.00 37.12 ? 145 LEU A CG 1 ATOM 1036 C CD1 . LEU A 1 129 ? 32.720 -5.328 -2.827 1.00 36.25 ? 145 LEU A CD1 1 ATOM 1037 C CD2 . LEU A 1 129 ? 31.759 -3.491 -1.408 1.00 36.40 ? 145 LEU A CD2 1 ATOM 1038 N N . ASP A 1 130 ? 28.115 -4.723 -3.973 1.00 37.84 ? 146 ASP A N 1 ATOM 1039 C CA . ASP A 1 130 ? 26.922 -5.345 -3.435 1.00 38.06 ? 146 ASP A CA 1 ATOM 1040 C C . ASP A 1 130 ? 25.828 -5.290 -4.503 1.00 37.97 ? 146 ASP A C 1 ATOM 1041 O O . ASP A 1 130 ? 25.318 -4.209 -4.798 1.00 38.28 ? 146 ASP A O 1 ATOM 1042 C CB . ASP A 1 130 ? 26.477 -4.608 -2.163 1.00 37.92 ? 146 ASP A CB 1 ATOM 1043 C CG . ASP A 1 130 ? 25.380 -5.344 -1.402 1.00 38.74 ? 146 ASP A CG 1 ATOM 1044 O OD1 . ASP A 1 130 ? 24.856 -6.359 -1.912 1.00 38.73 ? 146 ASP A OD1 1 ATOM 1045 O OD2 . ASP A 1 130 ? 25.041 -4.906 -0.278 1.00 38.64 ? 146 ASP A OD2 1 ATOM 1046 N N . PRO A 1 131 ? 25.436 -6.454 -5.063 1.00 38.00 ? 147 PRO A N 1 ATOM 1047 C CA . PRO A 1 131 ? 25.864 -7.806 -4.706 1.00 37.95 ? 147 PRO A CA 1 ATOM 1048 C C . PRO A 1 131 ? 26.854 -8.491 -5.659 1.00 37.98 ? 147 PRO A C 1 ATOM 1049 O O . PRO A 1 131 ? 27.370 -9.553 -5.315 1.00 37.72 ? 147 PRO A O 1 ATOM 1050 C CB . PRO A 1 131 ? 24.547 -8.580 -4.742 1.00 37.91 ? 147 PRO A CB 1 ATOM 1051 C CG . PRO A 1 131 ? 23.752 -7.900 -5.840 1.00 38.12 ? 147 PRO A CG 1 ATOM 1052 C CD . PRO A 1 131 ? 24.304 -6.492 -6.009 1.00 38.11 ? 147 PRO A CD 1 ATOM 1053 N N . GLU A 1 132 ? 27.107 -7.912 -6.834 1.00 38.14 ? 148 GLU A N 1 ATOM 1054 C CA . GLU A 1 132 ? 27.825 -8.638 -7.903 1.00 38.55 ? 148 GLU A CA 1 ATOM 1055 C C . GLU A 1 132 ? 29.247 -9.103 -7.555 1.00 38.57 ? 148 GLU A C 1 ATOM 1056 O O . GLU A 1 132 ? 29.561 -10.292 -7.691 1.00 38.67 ? 148 GLU A O 1 ATOM 1057 C CB . GLU A 1 132 ? 27.826 -7.856 -9.228 1.00 38.62 ? 148 GLU A CB 1 ATOM 1058 C CG . GLU A 1 132 ? 26.471 -7.794 -9.931 1.00 39.37 ? 148 GLU A CG 1 ATOM 1059 C CD . GLU A 1 132 ? 25.591 -6.647 -9.439 1.00 40.48 ? 148 GLU A CD 1 ATOM 1060 O OE1 . GLU A 1 132 ? 26.127 -5.654 -8.900 1.00 40.35 ? 148 GLU A OE1 1 ATOM 1061 O OE2 . GLU A 1 132 ? 24.355 -6.739 -9.599 1.00 41.80 ? 148 GLU A OE2 1 ATOM 1062 N N . ILE A 1 133 ? 30.096 -8.178 -7.107 1.00 38.48 ? 149 ILE A N 1 ATOM 1063 C CA . ILE A 1 133 ? 31.501 -8.506 -6.846 1.00 38.47 ? 149 ILE A CA 1 ATOM 1064 C C . ILE A 1 133 ? 31.653 -9.411 -5.621 1.00 38.75 ? 149 ILE A C 1 ATOM 1065 O O . ILE A 1 133 ? 32.418 -10.375 -5.654 1.00 38.41 ? 149 ILE A O 1 ATOM 1066 C CB . ILE A 1 133 ? 32.395 -7.247 -6.714 1.00 38.33 ? 149 ILE A CB 1 ATOM 1067 C CG1 . ILE A 1 133 ? 32.225 -6.327 -7.929 1.00 37.82 ? 149 ILE A CG1 1 ATOM 1068 C CG2 . ILE A 1 133 ? 33.866 -7.643 -6.567 1.00 38.24 ? 149 ILE A CG2 1 ATOM 1069 C CD1 . ILE A 1 133 ? 32.890 -4.970 -7.781 1.00 36.37 ? 149 ILE A CD1 1 ATOM 1070 N N . GLU A 1 134 ? 30.912 -9.107 -4.554 1.00 39.14 ? 150 GLU A N 1 ATOM 1071 C CA . GLU A 1 134 ? 30.950 -9.916 -3.338 1.00 39.60 ? 150 GLU A CA 1 ATOM 1072 C C . GLU A 1 134 ? 30.480 -11.346 -3.571 1.00 39.65 ? 150 GLU A C 1 ATOM 1073 O O . GLU A 1 134 ? 30.937 -12.266 -2.890 1.00 39.71 ? 150 GLU A O 1 ATOM 1074 C CB . GLU A 1 134 ? 30.126 -9.277 -2.223 1.00 39.77 ? 150 GLU A CB 1 ATOM 1075 C CG . GLU A 1 134 ? 30.846 -8.165 -1.484 1.00 41.07 ? 150 GLU A CG 1 ATOM 1076 C CD . GLU A 1 134 ? 30.169 -7.800 -0.176 1.00 43.57 ? 150 GLU A CD 1 ATOM 1077 O OE1 . GLU A 1 134 ? 28.922 -7.762 -0.133 1.00 44.96 ? 150 GLU A OE1 1 ATOM 1078 O OE2 . GLU A 1 134 ? 30.883 -7.548 0.815 1.00 44.26 ? 150 GLU A OE2 1 ATOM 1079 N N . GLU A 1 135 ? 29.562 -11.531 -4.520 1.00 39.72 ? 151 GLU A N 1 ATOM 1080 C CA . GLU A 1 135 ? 29.094 -12.873 -4.870 1.00 39.84 ? 151 GLU A CA 1 ATOM 1081 C C . GLU A 1 135 ? 30.212 -13.705 -5.507 1.00 39.43 ? 151 GLU A C 1 ATOM 1082 O O . GLU A 1 135 ? 30.357 -14.887 -5.196 1.00 39.37 ? 151 GLU A O 1 ATOM 1083 C CB . GLU A 1 135 ? 27.865 -12.825 -5.784 1.00 40.17 ? 151 GLU A CB 1 ATOM 1084 C CG . GLU A 1 135 ? 27.146 -14.167 -5.907 0.50 41.09 ? 151 GLU A CG 1 ATOM 1085 C CD . GLU A 1 135 ? 25.829 -14.085 -6.654 0.50 42.55 ? 151 GLU A CD 1 ATOM 1086 O OE1 . GLU A 1 135 ? 25.407 -12.968 -7.032 0.50 43.11 ? 151 GLU A OE1 1 ATOM 1087 O OE2 . GLU A 1 135 ? 25.210 -15.150 -6.860 0.50 43.38 ? 151 GLU A OE2 1 ATOM 1088 N N . VAL A 1 136 ? 30.999 -13.087 -6.385 1.00 39.15 ? 152 VAL A N 1 ATOM 1089 C CA . VAL A 1 136 ? 32.162 -13.762 -6.970 1.00 38.90 ? 152 VAL A CA 1 ATOM 1090 C C . VAL A 1 136 ? 33.220 -14.076 -5.897 1.00 38.81 ? 152 VAL A C 1 ATOM 1091 O O . VAL A 1 136 ? 33.679 -15.211 -5.790 1.00 38.52 ? 152 VAL A O 1 ATOM 1092 C CB . VAL A 1 136 ? 32.788 -12.955 -8.128 1.00 38.92 ? 152 VAL A CB 1 ATOM 1093 C CG1 . VAL A 1 136 ? 34.085 -13.606 -8.593 1.00 38.67 ? 152 VAL A CG1 1 ATOM 1094 C CG2 . VAL A 1 136 ? 31.810 -12.847 -9.295 1.00 39.22 ? 152 VAL A CG2 1 ATOM 1095 N N . ILE A 1 137 ? 33.582 -13.075 -5.096 1.00 38.68 ? 153 ILE A N 1 ATOM 1096 C CA . ILE A 1 137 ? 34.595 -13.251 -4.049 1.00 38.73 ? 153 ILE A CA 1 ATOM 1097 C C . ILE A 1 137 ? 34.227 -14.377 -3.086 1.00 38.74 ? 153 ILE A C 1 ATOM 1098 O O . ILE A 1 137 ? 35.099 -15.123 -2.630 1.00 38.67 ? 153 ILE A O 1 ATOM 1099 C CB . ILE A 1 137 ? 34.867 -11.933 -3.271 1.00 38.65 ? 153 ILE A CB 1 ATOM 1100 C CG1 . ILE A 1 137 ? 35.360 -10.825 -4.215 1.00 38.77 ? 153 ILE A CG1 1 ATOM 1101 C CG2 . ILE A 1 137 ? 35.863 -12.153 -2.130 1.00 39.26 ? 153 ILE A CG2 1 ATOM 1102 C CD1 . ILE A 1 137 ? 36.724 -11.063 -4.874 1.00 38.44 ? 153 ILE A CD1 1 ATOM 1103 N N . SER A 1 138 ? 32.936 -14.514 -2.801 1.00 39.04 ? 154 SER A N 1 ATOM 1104 C CA . SER A 1 138 ? 32.476 -15.516 -1.843 1.00 39.75 ? 154 SER A CA 1 ATOM 1105 C C . SER A 1 138 ? 32.280 -16.920 -2.426 1.00 39.57 ? 154 SER A C 1 ATOM 1106 O O . SER A 1 138 ? 32.390 -17.901 -1.698 1.00 39.45 ? 154 SER A O 1 ATOM 1107 C CB . SER A 1 138 ? 31.205 -15.046 -1.133 1.00 39.83 ? 154 SER A CB 1 ATOM 1108 O OG . SER A 1 138 ? 30.220 -14.654 -2.062 1.00 42.08 ? 154 SER A OG 1 ATOM 1109 N N . LYS A 1 139 ? 32.008 -17.019 -3.726 1.00 39.67 ? 155 LYS A N 1 ATOM 1110 C CA . LYS A 1 139 ? 31.632 -18.306 -4.323 1.00 39.98 ? 155 LYS A CA 1 ATOM 1111 C C . LYS A 1 139 ? 32.658 -18.887 -5.296 1.00 40.03 ? 155 LYS A C 1 ATOM 1112 O O . LYS A 1 139 ? 32.806 -20.104 -5.381 1.00 40.16 ? 155 LYS A O 1 ATOM 1113 C CB . LYS A 1 139 ? 30.256 -18.225 -5.011 1.00 40.17 ? 155 LYS A CB 1 ATOM 1114 C CG . LYS A 1 139 ? 29.094 -17.766 -4.114 1.00 41.12 ? 155 LYS A CG 1 ATOM 1115 C CD . LYS A 1 139 ? 28.976 -18.583 -2.821 1.00 42.07 ? 155 LYS A CD 1 ATOM 1116 C CE . LYS A 1 139 ? 27.995 -17.929 -1.847 1.00 42.75 ? 155 LYS A CE 1 ATOM 1117 N NZ . LYS A 1 139 ? 28.011 -18.587 -0.513 1.00 42.40 ? 155 LYS A NZ 1 ATOM 1118 N N . SER A 1 140 ? 33.341 -18.022 -6.038 1.00 40.00 ? 156 SER A N 1 ATOM 1119 C CA . SER A 1 140 ? 34.306 -18.469 -7.040 1.00 40.13 ? 156 SER A CA 1 ATOM 1120 C C . SER A 1 140 ? 35.544 -19.100 -6.407 1.00 40.02 ? 156 SER A C 1 ATOM 1121 O O . SER A 1 140 ? 36.066 -18.605 -5.405 1.00 39.57 ? 156 SER A O 1 ATOM 1122 C CB . SER A 1 140 ? 34.715 -17.311 -7.944 1.00 40.02 ? 156 SER A CB 1 ATOM 1123 O OG . SER A 1 140 ? 35.781 -17.685 -8.796 1.00 41.06 ? 156 SER A OG 1 ATOM 1124 N N . ARG A 1 141 ? 35.991 -20.208 -6.993 1.00 39.97 ? 157 ARG A N 1 ATOM 1125 C CA . ARG A 1 141 ? 37.256 -20.830 -6.602 1.00 40.13 ? 157 ARG A CA 1 ATOM 1126 C C . ARG A 1 141 ? 38.241 -20.816 -7.775 1.00 39.98 ? 157 ARG A C 1 ATOM 1127 O O . ARG A 1 141 ? 39.143 -21.650 -7.853 1.00 40.30 ? 157 ARG A O 1 ATOM 1128 C CB . ARG A 1 141 ? 37.049 -22.261 -6.075 1.00 40.32 ? 157 ARG A CB 1 ATOM 1129 C CG . ARG A 1 141 ? 35.849 -22.480 -5.144 1.00 41.06 ? 157 ARG A CG 1 ATOM 1130 C CD . ARG A 1 141 ? 35.961 -21.682 -3.861 1.00 42.45 ? 157 ARG A CD 1 ATOM 1131 N NE . ARG A 1 141 ? 35.103 -22.211 -2.804 1.00 43.45 ? 157 ARG A NE 1 ATOM 1132 C CZ . ARG A 1 141 ? 34.526 -21.471 -1.860 1.00 44.85 ? 157 ARG A CZ 1 ATOM 1133 N NH1 . ARG A 1 141 ? 34.682 -20.141 -1.841 1.00 44.85 ? 157 ARG A NH1 1 ATOM 1134 N NH2 . ARG A 1 141 ? 33.771 -22.058 -0.940 1.00 43.89 ? 157 ARG A NH2 1 ATOM 1135 N N . ASP A 1 142 ? 38.049 -19.871 -8.691 1.00 39.68 ? 158 ASP A N 1 ATOM 1136 C CA . ASP A 1 142 ? 38.990 -19.624 -9.778 1.00 39.57 ? 158 ASP A CA 1 ATOM 1137 C C . ASP A 1 142 ? 39.907 -18.499 -9.312 1.00 39.09 ? 158 ASP A C 1 ATOM 1138 O O . ASP A 1 142 ? 39.517 -17.328 -9.306 1.00 39.07 ? 158 ASP A O 1 ATOM 1139 C CB . ASP A 1 142 ? 38.237 -19.248 -11.067 1.00 39.73 ? 158 ASP A CB 1 ATOM 1140 C CG . ASP A 1 142 ? 39.167 -18.940 -12.248 1.00 40.39 ? 158 ASP A CG 1 ATOM 1141 O OD1 . ASP A 1 142 ? 40.232 -18.312 -12.071 1.00 40.43 ? 158 ASP A OD1 1 ATOM 1142 O OD2 . ASP A 1 142 ? 38.806 -19.304 -13.384 1.00 42.13 ? 158 ASP A OD2 1 ATOM 1143 N N . HIS A 1 143 ? 41.125 -18.866 -8.914 1.00 38.65 ? 159 HIS A N 1 ATOM 1144 C CA . HIS A 1 143 ? 42.049 -17.925 -8.273 1.00 38.01 ? 159 HIS A CA 1 ATOM 1145 C C . HIS A 1 143 ? 42.395 -16.714 -9.145 1.00 37.67 ? 159 HIS A C 1 ATOM 1146 O O . HIS A 1 143 ? 42.626 -15.623 -8.626 1.00 37.19 ? 159 HIS A O 1 ATOM 1147 C CB . HIS A 1 143 ? 43.313 -18.638 -7.777 1.00 38.06 ? 159 HIS A CB 1 ATOM 1148 C CG . HIS A 1 143 ? 44.058 -19.366 -8.851 1.00 37.96 ? 159 HIS A CG 1 ATOM 1149 N ND1 . HIS A 1 143 ? 45.156 -18.829 -9.488 1.00 37.70 ? 159 HIS A ND1 1 ATOM 1150 C CD2 . HIS A 1 143 ? 43.860 -20.586 -9.404 1.00 37.57 ? 159 HIS A CD2 1 ATOM 1151 C CE1 . HIS A 1 143 ? 45.603 -19.688 -10.386 1.00 37.32 ? 159 HIS A CE1 1 ATOM 1152 N NE2 . HIS A 1 143 ? 44.834 -20.762 -10.355 1.00 37.20 ? 159 HIS A NE2 1 ATOM 1153 N N . GLU A 1 144 ? 42.408 -16.896 -10.465 1.00 37.21 ? 160 GLU A N 1 ATOM 1154 C CA . GLU A 1 144 ? 42.695 -15.774 -11.362 1.00 37.01 ? 160 GLU A CA 1 ATOM 1155 C C . GLU A 1 144 ? 41.495 -14.839 -11.511 1.00 36.31 ? 160 GLU A C 1 ATOM 1156 O O . GLU A 1 144 ? 41.664 -13.627 -11.604 1.00 36.36 ? 160 GLU A O 1 ATOM 1157 C CB . GLU A 1 144 ? 43.217 -16.254 -12.718 1.00 37.08 ? 160 GLU A CB 1 ATOM 1158 C CG . GLU A 1 144 ? 44.549 -16.989 -12.606 1.00 38.81 ? 160 GLU A CG 1 ATOM 1159 C CD . GLU A 1 144 ? 45.414 -16.879 -13.848 1.00 41.28 ? 160 GLU A CD 1 ATOM 1160 O OE1 . GLU A 1 144 ? 44.874 -16.696 -14.965 1.00 42.60 ? 160 GLU A OE1 1 ATOM 1161 O OE2 . GLU A 1 144 ? 46.652 -16.977 -13.703 1.00 42.15 ? 160 GLU A OE2 1 ATOM 1162 N N . GLU A 1 145 ? 40.294 -15.411 -11.527 1.00 35.84 ? 161 GLU A N 1 ATOM 1163 C CA . GLU A 1 145 ? 39.060 -14.629 -11.509 1.00 35.61 ? 161 GLU A CA 1 ATOM 1164 C C . GLU A 1 145 ? 38.993 -13.795 -10.231 1.00 34.98 ? 161 GLU A C 1 ATOM 1165 O O . GLU A 1 145 ? 38.705 -12.601 -10.280 1.00 34.62 ? 161 GLU A O 1 ATOM 1166 C CB . GLU A 1 145 ? 37.836 -15.540 -11.609 1.00 35.80 ? 161 GLU A CB 1 ATOM 1167 C CG . GLU A 1 145 ? 36.498 -14.803 -11.512 1.00 37.13 ? 161 GLU A CG 1 ATOM 1168 C CD . GLU A 1 145 ? 35.289 -15.717 -11.659 1.00 38.77 ? 161 GLU A CD 1 ATOM 1169 O OE1 . GLU A 1 145 ? 35.351 -16.895 -11.243 1.00 39.55 ? 161 GLU A OE1 1 ATOM 1170 O OE2 . GLU A 1 145 ? 34.261 -15.246 -12.185 1.00 39.37 ? 161 GLU A OE2 1 ATOM 1171 N N . LEU A 1 146 ? 39.272 -14.435 -9.096 1.00 34.66 ? 162 LEU A N 1 ATOM 1172 C CA . LEU A 1 146 ? 39.300 -13.754 -7.795 1.00 34.19 ? 162 LEU A CA 1 ATOM 1173 C C . LEU A 1 146 ? 40.296 -12.592 -7.781 1.00 33.94 ? 162 LEU A C 1 ATOM 1174 O O . LEU A 1 146 ? 39.974 -11.500 -7.316 1.00 33.65 ? 162 LEU A O 1 ATOM 1175 C CB . LEU A 1 146 ? 39.612 -14.751 -6.671 1.00 34.02 ? 162 LEU A CB 1 ATOM 1176 C CG . LEU A 1 146 ? 38.557 -15.825 -6.383 1.00 34.34 ? 162 LEU A CG 1 ATOM 1177 C CD1 . LEU A 1 146 ? 39.158 -16.983 -5.601 1.00 34.88 ? 162 LEU A CD1 1 ATOM 1178 C CD2 . LEU A 1 146 ? 37.345 -15.243 -5.646 1.00 34.29 ? 162 LEU A CD2 1 ATOM 1179 N N . ALA A 1 147 ? 41.491 -12.827 -8.323 1.00 33.91 ? 163 ALA A N 1 ATOM 1180 C CA . ALA A 1 147 ? 42.538 -11.808 -8.370 1.00 33.66 ? 163 ALA A CA 1 ATOM 1181 C C . ALA A 1 147 ? 42.126 -10.620 -9.231 1.00 33.99 ? 163 ALA A C 1 ATOM 1182 O O . ALA A 1 147 ? 42.438 -9.471 -8.903 1.00 33.61 ? 163 ALA A O 1 ATOM 1183 C CB . ALA A 1 147 ? 43.839 -12.406 -8.870 1.00 33.48 ? 163 ALA A CB 1 ATOM 1184 N N . TYR A 1 148 ? 41.424 -10.903 -10.328 1.00 34.04 ? 164 TYR A N 1 ATOM 1185 C CA . TYR A 1 148 ? 40.928 -9.853 -11.212 1.00 34.28 ? 164 TYR A CA 1 ATOM 1186 C C . TYR A 1 148 ? 39.983 -8.906 -10.467 1.00 34.14 ? 164 TYR A C 1 ATOM 1187 O O . TYR A 1 148 ? 40.166 -7.693 -10.498 1.00 34.33 ? 164 TYR A O 1 ATOM 1188 C CB . TYR A 1 148 ? 40.222 -10.450 -12.444 1.00 34.46 ? 164 TYR A CB 1 ATOM 1189 C CG . TYR A 1 148 ? 39.414 -9.425 -13.214 1.00 35.01 ? 164 TYR A CG 1 ATOM 1190 C CD1 . TYR A 1 148 ? 40.021 -8.600 -14.162 1.00 35.68 ? 164 TYR A CD1 1 ATOM 1191 C CD2 . TYR A 1 148 ? 38.047 -9.267 -12.980 1.00 35.50 ? 164 TYR A CD2 1 ATOM 1192 C CE1 . TYR A 1 148 ? 39.284 -7.644 -14.865 1.00 36.06 ? 164 TYR A CE1 1 ATOM 1193 C CE2 . TYR A 1 148 ? 37.302 -8.315 -13.671 1.00 36.03 ? 164 TYR A CE2 1 ATOM 1194 C CZ . TYR A 1 148 ? 37.926 -7.512 -14.615 1.00 36.60 ? 164 TYR A CZ 1 ATOM 1195 O OH . TYR A 1 148 ? 37.191 -6.568 -15.299 1.00 37.30 ? 164 TYR A OH 1 ATOM 1196 N N . TYR A 1 149 ? 38.972 -9.468 -9.809 1.00 34.20 ? 165 TYR A N 1 ATOM 1197 C CA . TYR A 1 149 ? 37.977 -8.656 -9.103 1.00 34.53 ? 165 TYR A CA 1 ATOM 1198 C C . TYR A 1 149 ? 38.584 -7.896 -7.926 1.00 34.37 ? 165 TYR A C 1 ATOM 1199 O O . TYR A 1 149 ? 38.194 -6.761 -7.659 1.00 34.47 ? 165 TYR A O 1 ATOM 1200 C CB . TYR A 1 149 ? 36.762 -9.491 -8.684 1.00 34.40 ? 165 TYR A CB 1 ATOM 1201 C CG . TYR A 1 149 ? 35.835 -9.804 -9.846 1.00 35.75 ? 165 TYR A CG 1 ATOM 1202 C CD1 . TYR A 1 149 ? 35.080 -8.795 -10.452 1.00 36.97 ? 165 TYR A CD1 1 ATOM 1203 C CD2 . TYR A 1 149 ? 35.732 -11.099 -10.357 1.00 37.08 ? 165 TYR A CD2 1 ATOM 1204 C CE1 . TYR A 1 149 ? 34.236 -9.070 -11.525 1.00 37.95 ? 165 TYR A CE1 1 ATOM 1205 C CE2 . TYR A 1 149 ? 34.887 -11.387 -11.436 1.00 37.42 ? 165 TYR A CE2 1 ATOM 1206 C CZ . TYR A 1 149 ? 34.143 -10.366 -12.013 1.00 37.86 ? 165 TYR A CZ 1 ATOM 1207 O OH . TYR A 1 149 ? 33.300 -10.629 -13.072 1.00 37.66 ? 165 TYR A OH 1 ATOM 1208 N N . TRP A 1 150 ? 39.559 -8.510 -7.255 1.00 34.28 ? 166 TRP A N 1 ATOM 1209 C CA . TRP A 1 150 ? 40.302 -7.844 -6.179 1.00 34.16 ? 166 TRP A CA 1 ATOM 1210 C C . TRP A 1 150 ? 40.982 -6.578 -6.707 1.00 34.41 ? 166 TRP A C 1 ATOM 1211 O O . TRP A 1 150 ? 40.788 -5.479 -6.169 1.00 34.10 ? 166 TRP A O 1 ATOM 1212 C CB . TRP A 1 150 ? 41.336 -8.797 -5.558 1.00 33.84 ? 166 TRP A CB 1 ATOM 1213 C CG . TRP A 1 150 ? 41.963 -8.287 -4.273 1.00 32.45 ? 166 TRP A CG 1 ATOM 1214 C CD1 . TRP A 1 150 ? 41.646 -8.671 -3.003 1.00 31.52 ? 166 TRP A CD1 1 ATOM 1215 C CD2 . TRP A 1 150 ? 43.003 -7.306 -4.148 1.00 31.41 ? 166 TRP A CD2 1 ATOM 1216 N NE1 . TRP A 1 150 ? 42.426 -7.995 -2.090 1.00 30.47 ? 166 TRP A NE1 1 ATOM 1217 C CE2 . TRP A 1 150 ? 43.266 -7.150 -2.763 1.00 31.29 ? 166 TRP A CE2 1 ATOM 1218 C CE3 . TRP A 1 150 ? 43.744 -6.550 -5.065 1.00 31.24 ? 166 TRP A CE3 1 ATOM 1219 C CZ2 . TRP A 1 150 ? 44.232 -6.265 -2.278 1.00 30.60 ? 166 TRP A CZ2 1 ATOM 1220 C CZ3 . TRP A 1 150 ? 44.704 -5.664 -4.582 1.00 31.62 ? 166 TRP A CZ3 1 ATOM 1221 C CH2 . TRP A 1 150 ? 44.939 -5.532 -3.197 1.00 31.99 ? 166 TRP A CH2 1 ATOM 1222 N N . ARG A 1 151 ? 41.772 -6.737 -7.768 1.00 34.86 ? 167 ARG A N 1 ATOM 1223 C CA . ARG A 1 151 ? 42.502 -5.617 -8.354 1.00 35.57 ? 167 ARG A CA 1 ATOM 1224 C C . ARG A 1 151 ? 41.567 -4.506 -8.821 1.00 35.22 ? 167 ARG A C 1 ATOM 1225 O O . ARG A 1 151 ? 41.808 -3.337 -8.527 1.00 35.15 ? 167 ARG A O 1 ATOM 1226 C CB . ARG A 1 151 ? 43.397 -6.072 -9.512 1.00 36.02 ? 167 ARG A CB 1 ATOM 1227 C CG . ARG A 1 151 ? 44.439 -5.032 -9.912 1.00 38.57 ? 167 ARG A CG 1 ATOM 1228 C CD . ARG A 1 151 ? 44.833 -5.128 -11.385 1.00 42.67 ? 167 ARG A CD 1 ATOM 1229 N NE . ARG A 1 151 ? 45.731 -6.246 -11.675 1.00 46.45 ? 167 ARG A NE 1 ATOM 1230 C CZ . ARG A 1 151 ? 47.048 -6.253 -11.454 1.00 48.13 ? 167 ARG A CZ 1 ATOM 1231 N NH1 . ARG A 1 151 ? 47.662 -5.205 -10.911 1.00 48.86 ? 167 ARG A NH1 1 ATOM 1232 N NH2 . ARG A 1 151 ? 47.758 -7.328 -11.770 1.00 49.04 ? 167 ARG A NH2 1 ATOM 1233 N N . GLU A 1 152 ? 40.508 -4.874 -9.542 1.00 35.24 ? 168 GLU A N 1 ATOM 1234 C CA . GLU A 1 152 ? 39.560 -3.893 -10.080 1.00 34.96 ? 168 GLU A CA 1 ATOM 1235 C C . GLU A 1 152 ? 38.901 -3.091 -8.958 1.00 34.57 ? 168 GLU A C 1 ATOM 1236 O O . GLU A 1 152 ? 38.828 -1.864 -9.029 1.00 34.41 ? 168 GLU A O 1 ATOM 1237 C CB . GLU A 1 152 ? 38.499 -4.569 -10.953 1.00 35.11 ? 168 GLU A CB 1 ATOM 1238 C CG . GLU A 1 152 ? 39.039 -5.143 -12.269 1.00 36.30 ? 168 GLU A CG 1 ATOM 1239 C CD . GLU A 1 152 ? 39.783 -4.116 -13.098 1.00 37.33 ? 168 GLU A CD 1 ATOM 1240 O OE1 . GLU A 1 152 ? 39.155 -3.132 -13.542 1.00 38.83 ? 168 GLU A OE1 1 ATOM 1241 O OE2 . GLU A 1 152 ? 41.004 -4.285 -13.295 1.00 38.74 ? 168 GLU A OE2 1 ATOM 1242 N N . PHE A 1 153 ? 38.449 -3.782 -7.915 1.00 34.10 ? 169 PHE A N 1 ATOM 1243 C CA . PHE A 1 153 ? 37.799 -3.107 -6.791 1.00 33.87 ? 169 PHE A CA 1 ATOM 1244 C C . PHE A 1 153 ? 38.740 -2.176 -6.017 1.00 33.64 ? 169 PHE A C 1 ATOM 1245 O O . PHE A 1 153 ? 38.412 -1.010 -5.790 1.00 34.00 ? 169 PHE A O 1 ATOM 1246 C CB . PHE A 1 153 ? 37.111 -4.107 -5.847 1.00 33.80 ? 169 PHE A CB 1 ATOM 1247 C CG . PHE A 1 153 ? 36.359 -3.445 -4.726 1.00 34.13 ? 169 PHE A CG 1 ATOM 1248 C CD1 . PHE A 1 153 ? 35.135 -2.819 -4.965 1.00 34.31 ? 169 PHE A CD1 1 ATOM 1249 C CD2 . PHE A 1 153 ? 36.890 -3.409 -3.440 1.00 34.26 ? 169 PHE A CD2 1 ATOM 1250 C CE1 . PHE A 1 153 ? 34.443 -2.185 -3.935 1.00 34.73 ? 169 PHE A CE1 1 ATOM 1251 C CE2 . PHE A 1 153 ? 36.204 -2.777 -2.405 1.00 34.26 ? 169 PHE A CE2 1 ATOM 1252 C CZ . PHE A 1 153 ? 34.979 -2.164 -2.655 1.00 33.63 ? 169 PHE A CZ 1 ATOM 1253 N N . TYR A 1 154 ? 39.906 -2.680 -5.620 1.00 33.31 ? 170 TYR A N 1 ATOM 1254 C CA . TYR A 1 154 ? 40.844 -1.880 -4.822 1.00 32.92 ? 170 TYR A CA 1 ATOM 1255 C C . TYR A 1 154 ? 41.355 -0.646 -5.569 1.00 33.13 ? 170 TYR A C 1 ATOM 1256 O O . TYR A 1 154 ? 41.501 0.422 -4.978 1.00 32.85 ? 170 TYR A O 1 ATOM 1257 C CB . TYR A 1 154 ? 42.007 -2.737 -4.318 1.00 32.41 ? 170 TYR A CB 1 ATOM 1258 C CG . TYR A 1 154 ? 41.710 -3.502 -3.041 1.00 31.48 ? 170 TYR A CG 1 ATOM 1259 C CD1 . TYR A 1 154 ? 40.902 -4.638 -3.051 1.00 30.00 ? 170 TYR A CD1 1 ATOM 1260 C CD2 . TYR A 1 154 ? 42.252 -3.092 -1.817 1.00 30.33 ? 170 TYR A CD2 1 ATOM 1261 C CE1 . TYR A 1 154 ? 40.635 -5.340 -1.876 1.00 30.00 ? 170 TYR A CE1 1 ATOM 1262 C CE2 . TYR A 1 154 ? 41.994 -3.795 -0.634 1.00 29.50 ? 170 TYR A CE2 1 ATOM 1263 C CZ . TYR A 1 154 ? 41.194 -4.913 -0.672 1.00 30.04 ? 170 TYR A CZ 1 ATOM 1264 O OH . TYR A 1 154 ? 40.937 -5.616 0.485 1.00 29.52 ? 170 TYR A OH 1 ATOM 1265 N N . ASP A 1 155 ? 41.615 -0.795 -6.867 1.00 33.31 ? 171 ASP A N 1 ATOM 1266 C CA . ASP A 1 155 ? 42.008 0.333 -7.707 1.00 33.59 ? 171 ASP A CA 1 ATOM 1267 C C . ASP A 1 155 ? 40.937 1.432 -7.719 1.00 33.61 ? 171 ASP A C 1 ATOM 1268 O O . ASP A 1 155 ? 41.268 2.616 -7.657 1.00 33.49 ? 171 ASP A O 1 ATOM 1269 C CB . ASP A 1 155 ? 42.323 -0.130 -9.141 1.00 33.66 ? 171 ASP A CB 1 ATOM 1270 C CG . ASP A 1 155 ? 43.633 -0.908 -9.242 1.00 34.77 ? 171 ASP A CG 1 ATOM 1271 O OD1 . ASP A 1 155 ? 44.394 -0.989 -8.243 1.00 34.34 ? 171 ASP A OD1 1 ATOM 1272 O OD2 . ASP A 1 155 ? 43.909 -1.446 -10.338 1.00 35.21 ? 171 ASP A OD2 1 ATOM 1273 N N . LYS A 1 156 ? 39.663 1.032 -7.764 1.00 33.94 ? 172 LYS A N 1 ATOM 1274 C CA . LYS A 1 156 ? 38.540 1.979 -7.860 1.00 34.64 ? 172 LYS A CA 1 ATOM 1275 C C . LYS A 1 156 ? 38.031 2.524 -6.521 1.00 34.56 ? 172 LYS A C 1 ATOM 1276 O O . LYS A 1 156 ? 37.707 3.709 -6.415 1.00 34.71 ? 172 LYS A O 1 ATOM 1277 C CB . LYS A 1 156 ? 37.372 1.357 -8.630 1.00 34.89 ? 172 LYS A CB 1 ATOM 1278 C CG . LYS A 1 156 ? 37.651 1.137 -10.113 1.00 36.11 ? 172 LYS A CG 1 ATOM 1279 C CD . LYS A 1 156 ? 36.521 0.360 -10.763 1.00 38.22 ? 172 LYS A CD 1 ATOM 1280 C CE . LYS A 1 156 ? 36.947 -0.255 -12.098 1.00 40.09 ? 172 LYS A CE 1 ATOM 1281 N NZ . LYS A 1 156 ? 37.195 0.774 -13.147 1.00 40.34 ? 172 LYS A NZ 1 ATOM 1282 N N . ALA A 1 157 ? 37.950 1.664 -5.512 1.00 34.43 ? 173 ALA A N 1 ATOM 1283 C CA . ALA A 1 157 ? 37.431 2.067 -4.207 1.00 34.31 ? 173 ALA A CA 1 ATOM 1284 C C . ALA A 1 157 ? 38.518 2.641 -3.306 1.00 34.46 ? 173 ALA A C 1 ATOM 1285 O O . ALA A 1 157 ? 38.236 3.455 -2.429 1.00 34.95 ? 173 ALA A O 1 ATOM 1286 C CB . ALA A 1 157 ? 36.743 0.907 -3.537 1.00 33.96 ? 173 ALA A CB 1 ATOM 1287 N N . GLY A 1 158 ? 39.760 2.218 -3.520 1.00 34.59 ? 174 GLY A N 1 ATOM 1288 C CA . GLY A 1 158 ? 40.881 2.709 -2.733 1.00 34.14 ? 174 GLY A CA 1 ATOM 1289 C C . GLY A 1 158 ? 41.686 3.814 -3.396 1.00 34.02 ? 174 GLY A C 1 ATOM 1290 O O . GLY A 1 158 ? 41.607 4.985 -3.004 1.00 33.69 ? 174 GLY A O 1 ATOM 1291 N N . THR A 1 159 ? 42.473 3.438 -4.398 1.00 34.11 ? 175 THR A N 1 ATOM 1292 C CA . THR A 1 159 ? 43.453 4.343 -5.004 1.00 34.07 ? 175 THR A CA 1 ATOM 1293 C C . THR A 1 159 ? 42.856 5.673 -5.481 1.00 34.31 ? 175 THR A C 1 ATOM 1294 O O . THR A 1 159 ? 43.498 6.712 -5.368 1.00 34.02 ? 175 THR A O 1 ATOM 1295 C CB . THR A 1 159 ? 44.202 3.654 -6.162 1.00 34.06 ? 175 THR A CB 1 ATOM 1296 O OG1 . THR A 1 159 ? 44.756 2.415 -5.698 1.00 32.89 ? 175 THR A OG1 1 ATOM 1297 C CG2 . THR A 1 159 ? 45.327 4.548 -6.704 1.00 33.87 ? 175 THR A CG2 1 ATOM 1298 N N . ALA A 1 160 ? 41.622 5.633 -5.981 1.00 34.81 ? 176 ALA A N 1 ATOM 1299 C CA . ALA A 1 160 ? 40.981 6.814 -6.572 1.00 35.51 ? 176 ALA A CA 1 ATOM 1300 C C . ALA A 1 160 ? 40.751 7.978 -5.595 1.00 35.90 ? 176 ALA A C 1 ATOM 1301 O O . ALA A 1 160 ? 40.549 9.118 -6.026 1.00 35.88 ? 176 ALA A O 1 ATOM 1302 C CB . ALA A 1 160 ? 39.678 6.423 -7.260 1.00 35.27 ? 176 ALA A CB 1 ATOM 1303 N N . VAL A 1 161 ? 40.790 7.699 -4.292 1.00 36.29 ? 177 VAL A N 1 ATOM 1304 C CA . VAL A 1 161 ? 40.542 8.743 -3.288 1.00 36.52 ? 177 VAL A CA 1 ATOM 1305 C C . VAL A 1 161 ? 41.724 9.057 -2.366 1.00 37.13 ? 177 VAL A C 1 ATOM 1306 O O . VAL A 1 161 ? 41.528 9.536 -1.241 1.00 37.19 ? 177 VAL A O 1 ATOM 1307 C CB . VAL A 1 161 ? 39.264 8.471 -2.444 1.00 36.57 ? 177 VAL A CB 1 ATOM 1308 C CG1 . VAL A 1 161 ? 38.020 8.520 -3.321 1.00 36.52 ? 177 VAL A CG1 1 ATOM 1309 C CG2 . VAL A 1 161 ? 39.359 7.143 -1.678 1.00 36.25 ? 177 VAL A CG2 1 ATOM 1310 N N . ARG A 1 162 ? 42.943 8.800 -2.837 1.00 37.68 ? 178 ARG A N 1 ATOM 1311 C CA . ARG A 1 162 ? 44.138 9.124 -2.052 1.00 38.29 ? 178 ARG A CA 1 ATOM 1312 C C . ARG A 1 162 ? 44.192 10.604 -1.640 1.00 38.23 ? 178 ARG A C 1 ATOM 1313 O O . ARG A 1 162 ? 44.348 10.915 -0.451 1.00 37.93 ? 178 ARG A O 1 ATOM 1314 C CB . ARG A 1 162 ? 45.427 8.728 -2.783 1.00 38.72 ? 178 ARG A CB 1 ATOM 1315 C CG . ARG A 1 162 ? 46.681 9.123 -2.007 1.00 40.38 ? 178 ARG A CG 1 ATOM 1316 C CD . ARG A 1 162 ? 47.947 9.035 -2.845 1.00 44.08 ? 178 ARG A CD 1 ATOM 1317 N NE . ARG A 1 162 ? 48.606 7.730 -2.733 1.00 46.73 ? 178 ARG A NE 1 ATOM 1318 C CZ . ARG A 1 162 ? 49.359 7.336 -1.703 1.00 47.86 ? 178 ARG A CZ 1 ATOM 1319 N NH1 . ARG A 1 162 ? 49.566 8.130 -0.648 1.00 47.08 ? 178 ARG A NH1 1 ATOM 1320 N NH2 . ARG A 1 162 ? 49.905 6.125 -1.729 1.00 48.71 ? 178 ARG A NH2 1 ATOM 1321 N N . SER A 1 163 ? 44.057 11.507 -2.612 1.00 37.79 ? 179 SER A N 1 ATOM 1322 C CA . SER A 1 163 ? 44.127 12.947 -2.329 1.00 37.92 ? 179 SER A CA 1 ATOM 1323 C C . SER A 1 163 ? 43.060 13.405 -1.328 1.00 37.35 ? 179 SER A C 1 ATOM 1324 O O . SER A 1 163 ? 43.351 14.190 -0.422 1.00 37.11 ? 179 SER A O 1 ATOM 1325 C CB . SER A 1 163 ? 44.043 13.771 -3.622 1.00 37.88 ? 179 SER A CB 1 ATOM 1326 O OG . SER A 1 163 ? 42.795 13.559 -4.262 1.00 39.19 ? 179 SER A OG 1 ATOM 1327 N N . GLN A 1 164 ? 41.835 12.907 -1.495 1.00 37.22 ? 180 GLN A N 1 ATOM 1328 C CA . GLN A 1 164 ? 40.738 13.208 -0.568 1.00 37.29 ? 180 GLN A CA 1 ATOM 1329 C C . GLN A 1 164 ? 41.018 12.649 0.828 1.00 37.00 ? 180 GLN A C 1 ATOM 1330 O O . GLN A 1 164 ? 40.778 13.321 1.830 1.00 36.42 ? 180 GLN A O 1 ATOM 1331 C CB . GLN A 1 164 ? 39.403 12.667 -1.080 1.00 37.33 ? 180 GLN A CB 1 ATOM 1332 C CG . GLN A 1 164 ? 38.841 13.398 -2.298 1.00 39.02 ? 180 GLN A CG 1 ATOM 1333 C CD . GLN A 1 164 ? 39.220 12.742 -3.618 1.00 40.73 ? 180 GLN A CD 1 ATOM 1334 O OE1 . GLN A 1 164 ? 40.151 11.936 -3.691 1.00 40.84 ? 180 GLN A OE1 1 ATOM 1335 N NE2 . GLN A 1 164 ? 38.494 13.092 -4.674 1.00 42.22 ? 180 GLN A NE2 1 ATOM 1336 N N . PHE A 1 165 ? 41.531 11.422 0.881 1.00 36.79 ? 181 PHE A N 1 ATOM 1337 C CA . PHE A 1 165 ? 41.866 10.803 2.157 1.00 36.76 ? 181 PHE A CA 1 ATOM 1338 C C . PHE A 1 165 ? 42.958 11.578 2.901 1.00 36.99 ? 181 PHE A C 1 ATOM 1339 O O . PHE A 1 165 ? 42.878 11.758 4.122 1.00 37.10 ? 181 PHE A O 1 ATOM 1340 C CB . PHE A 1 165 ? 42.257 9.332 1.989 1.00 36.53 ? 181 PHE A CB 1 ATOM 1341 C CG . PHE A 1 165 ? 42.312 8.584 3.295 1.00 35.76 ? 181 PHE A CG 1 ATOM 1342 C CD1 . PHE A 1 165 ? 41.161 8.021 3.832 1.00 34.61 ? 181 PHE A CD1 1 ATOM 1343 C CD2 . PHE A 1 165 ? 43.504 8.479 4.003 1.00 34.92 ? 181 PHE A CD2 1 ATOM 1344 C CE1 . PHE A 1 165 ? 41.202 7.346 5.053 1.00 35.61 ? 181 PHE A CE1 1 ATOM 1345 C CE2 . PHE A 1 165 ? 43.551 7.803 5.226 1.00 34.86 ? 181 PHE A CE2 1 ATOM 1346 C CZ . PHE A 1 165 ? 42.403 7.237 5.748 1.00 33.91 ? 181 PHE A CZ 1 ATOM 1347 N N . GLU A 1 166 ? 43.958 12.047 2.159 1.00 36.97 ? 182 GLU A N 1 ATOM 1348 C CA . GLU A 1 166 ? 45.022 12.871 2.720 1.00 37.18 ? 182 GLU A CA 1 ATOM 1349 C C . GLU A 1 166 ? 44.490 14.156 3.342 1.00 36.76 ? 182 GLU A C 1 ATOM 1350 O O . GLU A 1 166 ? 44.897 14.526 4.453 1.00 36.55 ? 182 GLU A O 1 ATOM 1351 C CB . GLU A 1 166 ? 46.074 13.202 1.662 1.00 37.52 ? 182 GLU A CB 1 ATOM 1352 C CG . GLU A 1 166 ? 46.954 12.024 1.277 1.00 39.75 ? 182 GLU A CG 1 ATOM 1353 C CD . GLU A 1 166 ? 48.081 12.412 0.335 1.00 42.37 ? 182 GLU A CD 1 ATOM 1354 O OE1 . GLU A 1 166 ? 48.335 13.627 0.163 1.00 44.34 ? 182 GLU A OE1 1 ATOM 1355 O OE2 . GLU A 1 166 ? 48.720 11.498 -0.225 1.00 43.17 ? 182 GLU A OE2 1 ATOM 1356 N N . ARG A 1 167 ? 43.584 14.833 2.632 1.00 36.09 ? 183 ARG A N 1 ATOM 1357 C CA . ARG A 1 167 ? 42.973 16.057 3.151 1.00 35.72 ? 183 ARG A CA 1 ATOM 1358 C C . ARG A 1 167 ? 42.104 15.774 4.385 1.00 35.23 ? 183 ARG A C 1 ATOM 1359 O O . ARG A 1 167 ? 42.089 16.562 5.336 1.00 34.89 ? 183 ARG A O 1 ATOM 1360 C CB . ARG A 1 167 ? 42.174 16.793 2.063 1.00 36.11 ? 183 ARG A CB 1 ATOM 1361 C CG . ARG A 1 167 ? 41.635 18.183 2.483 1.00 36.66 ? 183 ARG A CG 1 ATOM 1362 C CD . ARG A 1 167 ? 42.751 19.146 2.913 1.00 37.97 ? 183 ARG A CD 1 ATOM 1363 N NE . ARG A 1 167 ? 42.211 20.452 3.289 1.00 38.78 ? 183 ARG A NE 1 ATOM 1364 C CZ . ARG A 1 167 ? 42.736 21.262 4.206 1.00 39.23 ? 183 ARG A CZ 1 ATOM 1365 N NH1 . ARG A 1 167 ? 43.827 20.915 4.871 1.00 39.11 ? 183 ARG A NH1 1 ATOM 1366 N NH2 . ARG A 1 167 ? 42.157 22.427 4.468 1.00 39.08 ? 183 ARG A NH2 1 ATOM 1367 N N . TYR A 1 168 ? 41.397 14.643 4.356 1.00 34.59 ? 184 TYR A N 1 ATOM 1368 C CA . TYR A 1 168 ? 40.587 14.181 5.481 1.00 34.29 ? 184 TYR A CA 1 ATOM 1369 C C . TYR A 1 168 ? 41.421 13.989 6.759 1.00 33.99 ? 184 TYR A C 1 ATOM 1370 O O . TYR A 1 168 ? 41.017 14.436 7.832 1.00 33.74 ? 184 TYR A O 1 ATOM 1371 C CB . TYR A 1 168 ? 39.843 12.894 5.099 1.00 34.24 ? 184 TYR A CB 1 ATOM 1372 C CG . TYR A 1 168 ? 39.552 11.934 6.238 1.00 33.68 ? 184 TYR A CG 1 ATOM 1373 C CD1 . TYR A 1 168 ? 38.574 12.223 7.195 1.00 33.26 ? 184 TYR A CD1 1 ATOM 1374 C CD2 . TYR A 1 168 ? 40.235 10.718 6.340 1.00 33.05 ? 184 TYR A CD2 1 ATOM 1375 C CE1 . TYR A 1 168 ? 38.301 11.338 8.233 1.00 32.59 ? 184 TYR A CE1 1 ATOM 1376 C CE2 . TYR A 1 168 ? 39.964 9.821 7.376 1.00 32.63 ? 184 TYR A CE2 1 ATOM 1377 C CZ . TYR A 1 168 ? 38.998 10.140 8.317 1.00 32.28 ? 184 TYR A CZ 1 ATOM 1378 O OH . TYR A 1 168 ? 38.720 9.256 9.341 1.00 31.98 ? 184 TYR A OH 1 ATOM 1379 N N . VAL A 1 169 ? 42.575 13.335 6.628 1.00 33.87 ? 185 VAL A N 1 ATOM 1380 C CA . VAL A 1 169 ? 43.496 13.136 7.753 1.00 34.00 ? 185 VAL A CA 1 ATOM 1381 C C . VAL A 1 169 ? 43.958 14.479 8.323 1.00 34.22 ? 185 VAL A C 1 ATOM 1382 O O . VAL A 1 169 ? 43.981 14.665 9.546 1.00 33.89 ? 185 VAL A O 1 ATOM 1383 C CB . VAL A 1 169 ? 44.701 12.228 7.368 1.00 33.99 ? 185 VAL A CB 1 ATOM 1384 C CG1 . VAL A 1 169 ? 45.788 12.241 8.447 1.00 33.57 ? 185 VAL A CG1 1 ATOM 1385 C CG2 . VAL A 1 169 ? 44.225 10.798 7.120 1.00 33.72 ? 185 VAL A CG2 1 ATOM 1386 N N . GLU A 1 170 ? 44.294 15.414 7.434 1.00 34.18 ? 186 GLU A N 1 ATOM 1387 C CA . GLU A 1 170 ? 44.693 16.762 7.841 1.00 34.57 ? 186 GLU A CA 1 ATOM 1388 C C . GLU A 1 170 ? 43.614 17.474 8.651 1.00 34.18 ? 186 GLU A C 1 ATOM 1389 O O . GLU A 1 170 ? 43.902 18.061 9.700 1.00 34.55 ? 186 GLU A O 1 ATOM 1390 C CB . GLU A 1 170 ? 45.067 17.614 6.623 1.00 34.71 ? 186 GLU A CB 1 ATOM 1391 C CG . GLU A 1 170 ? 46.481 17.397 6.131 1.00 36.82 ? 186 GLU A CG 1 ATOM 1392 C CD . GLU A 1 170 ? 46.745 18.033 4.771 1.00 40.14 ? 186 GLU A CD 1 ATOM 1393 O OE1 . GLU A 1 170 ? 45.923 18.864 4.310 1.00 40.50 ? 186 GLU A OE1 1 ATOM 1394 O OE2 . GLU A 1 170 ? 47.785 17.691 4.164 1.00 41.91 ? 186 GLU A OE2 1 ATOM 1395 N N . LEU A 1 171 ? 42.378 17.422 8.163 1.00 33.60 ? 187 LEU A N 1 ATOM 1396 C CA . LEU A 1 171 ? 41.271 18.101 8.826 1.00 33.25 ? 187 LEU A CA 1 ATOM 1397 C C . LEU A 1 171 ? 40.792 17.378 10.083 1.00 32.90 ? 187 LEU A C 1 ATOM 1398 O O . LEU A 1 171 ? 40.364 18.023 11.039 1.00 32.74 ? 187 LEU A O 1 ATOM 1399 C CB . LEU A 1 171 ? 40.116 18.351 7.855 1.00 33.33 ? 187 LEU A CB 1 ATOM 1400 C CG . LEU A 1 171 ? 40.416 19.370 6.742 1.00 34.02 ? 187 LEU A CG 1 ATOM 1401 C CD1 . LEU A 1 171 ? 39.318 19.373 5.691 1.00 34.04 ? 187 LEU A CD1 1 ATOM 1402 C CD2 . LEU A 1 171 ? 40.624 20.771 7.300 1.00 35.22 ? 187 LEU A CD2 1 ATOM 1403 N N . ASN A 1 172 ? 40.864 16.047 10.074 1.00 32.42 ? 188 ASN A N 1 ATOM 1404 C CA . ASN A 1 172 ? 40.605 15.248 11.274 1.00 32.35 ? 188 ASN A CA 1 ATOM 1405 C C . ASN A 1 172 ? 41.580 15.615 12.398 1.00 32.27 ? 188 ASN A C 1 ATOM 1406 O O . ASN A 1 172 ? 41.179 15.748 13.553 1.00 32.40 ? 188 ASN A O 1 ATOM 1407 C CB . ASN A 1 172 ? 40.653 13.742 10.959 1.00 31.98 ? 188 ASN A CB 1 ATOM 1408 C CG . ASN A 1 172 ? 40.481 12.865 12.205 1.00 32.23 ? 188 ASN A CG 1 ATOM 1409 O OD1 . ASN A 1 172 ? 41.376 12.782 13.044 1.00 32.25 ? 188 ASN A OD1 1 ATOM 1410 N ND2 . ASN A 1 172 ? 39.339 12.193 12.312 1.00 30.75 ? 188 ASN A ND2 1 ATOM 1411 N N . THR A 1 173 ? 42.854 15.788 12.047 1.00 32.17 ? 189 THR A N 1 ATOM 1412 C CA . THR A 1 173 ? 43.893 16.145 13.017 1.00 32.06 ? 189 THR A CA 1 ATOM 1413 C C . THR A 1 173 ? 43.673 17.553 13.573 1.00 32.24 ? 189 THR A C 1 ATOM 1414 O O . THR A 1 173 ? 43.748 17.776 14.797 1.00 31.95 ? 189 THR A O 1 ATOM 1415 C CB . THR A 1 173 ? 45.311 16.014 12.404 1.00 31.99 ? 189 THR A CB 1 ATOM 1416 O OG1 . THR A 1 173 ? 45.464 14.705 11.846 1.00 31.48 ? 189 THR A OG1 1 ATOM 1417 C CG2 . THR A 1 173 ? 46.394 16.239 13.463 1.00 31.05 ? 189 THR A CG2 1 ATOM 1418 N N . LYS A 1 174 ? 43.390 18.489 12.668 1.00 32.22 ? 190 LYS A N 1 ATOM 1419 C CA . LYS A 1 174 ? 43.095 19.866 13.047 1.00 32.57 ? 190 LYS A CA 1 ATOM 1420 C C . LYS A 1 174 ? 41.904 19.944 14.009 1.00 32.40 ? 190 LYS A C 1 ATOM 1421 O O . LYS A 1 174 ? 41.964 20.663 15.009 1.00 32.03 ? 190 LYS A O 1 ATOM 1422 C CB . LYS A 1 174 ? 42.867 20.745 11.807 1.00 32.79 ? 190 LYS A CB 1 ATOM 1423 C CG . LYS A 1 174 ? 42.695 22.230 12.145 1.00 34.00 ? 190 LYS A CG 1 ATOM 1424 C CD . LYS A 1 174 ? 42.672 23.121 10.910 1.00 35.34 ? 190 LYS A CD 1 ATOM 1425 C CE . LYS A 1 174 ? 42.558 24.578 11.329 1.00 36.29 ? 190 LYS A CE 1 ATOM 1426 N NZ . LYS A 1 174 ? 42.501 25.490 10.154 1.00 37.77 ? 190 LYS A NZ 1 ATOM 1427 N N . ALA A 1 175 ? 40.842 19.194 13.702 1.00 32.19 ? 191 ALA A N 1 ATOM 1428 C CA . ALA A 1 175 ? 39.655 19.114 14.552 1.00 32.20 ? 191 ALA A CA 1 ATOM 1429 C C . ALA A 1 175 ? 39.987 18.575 15.940 1.00 32.34 ? 191 ALA A C 1 ATOM 1430 O O . ALA A 1 175 ? 39.534 19.120 16.949 1.00 32.69 ? 191 ALA A O 1 ATOM 1431 C CB . ALA A 1 175 ? 38.588 18.249 13.899 1.00 31.87 ? 191 ALA A CB 1 ATOM 1432 N N . ALA A 1 176 ? 40.763 17.494 15.975 1.00 32.37 ? 192 ALA A N 1 ATOM 1433 C CA . ALA A 1 176 ? 41.175 16.855 17.222 1.00 32.66 ? 192 ALA A CA 1 ATOM 1434 C C . ALA A 1 176 ? 41.939 17.821 18.126 1.00 32.92 ? 192 ALA A C 1 ATOM 1435 O O . ALA A 1 176 ? 41.654 17.918 19.324 1.00 32.61 ? 192 ALA A O 1 ATOM 1436 C CB . ALA A 1 176 ? 42.021 15.633 16.927 1.00 32.29 ? 192 ALA A CB 1 ATOM 1437 N N . LYS A 1 177 ? 42.896 18.538 17.534 1.00 33.10 ? 193 LYS A N 1 ATOM 1438 C CA . LYS A 1 177 ? 43.732 19.483 18.271 1.00 33.78 ? 193 LYS A CA 1 ATOM 1439 C C . LYS A 1 177 ? 42.948 20.688 18.781 1.00 34.02 ? 193 LYS A C 1 ATOM 1440 O O . LYS A 1 177 ? 43.248 21.199 19.862 1.00 34.10 ? 193 LYS A O 1 ATOM 1441 C CB . LYS A 1 177 ? 44.950 19.915 17.441 1.00 33.84 ? 193 LYS A CB 1 ATOM 1442 C CG . LYS A 1 177 ? 45.964 18.795 17.222 1.00 34.24 ? 193 LYS A CG 1 ATOM 1443 C CD . LYS A 1 177 ? 47.202 19.268 16.469 1.00 35.25 ? 193 LYS A CD 1 ATOM 1444 C CE . LYS A 1 177 ? 48.216 18.146 16.313 1.00 35.56 ? 193 LYS A CE 1 ATOM 1445 N NZ . LYS A 1 177 ? 48.641 17.579 17.633 1.00 35.98 ? 193 LYS A NZ 1 ATOM 1446 N N . LEU A 1 178 ? 41.938 21.126 18.021 1.00 33.88 ? 194 LEU A N 1 ATOM 1447 C CA . LEU A 1 178 ? 41.026 22.183 18.485 1.00 34.15 ? 194 LEU A CA 1 ATOM 1448 C C . LEU A 1 178 ? 40.216 21.752 19.709 1.00 34.10 ? 194 LEU A C 1 ATOM 1449 O O . LEU A 1 178 ? 39.767 22.587 20.490 1.00 33.83 ? 194 LEU A O 1 ATOM 1450 C CB . LEU A 1 178 ? 40.084 22.650 17.367 1.00 34.17 ? 194 LEU A CB 1 ATOM 1451 C CG . LEU A 1 178 ? 40.697 23.616 16.345 1.00 34.83 ? 194 LEU A CG 1 ATOM 1452 C CD1 . LEU A 1 178 ? 39.817 23.746 15.119 1.00 34.44 ? 194 LEU A CD1 1 ATOM 1453 C CD2 . LEU A 1 178 ? 40.975 24.990 16.967 1.00 35.51 ? 194 LEU A CD2 1 ATOM 1454 N N . ASN A 1 179 ? 40.024 20.443 19.857 1.00 34.09 ? 195 ASN A N 1 ATOM 1455 C CA . ASN A 1 179 ? 39.382 19.889 21.042 1.00 34.01 ? 195 ASN A CA 1 ATOM 1456 C C . ASN A 1 179 ? 40.397 19.530 22.126 1.00 33.73 ? 195 ASN A C 1 ATOM 1457 O O . ASN A 1 179 ? 40.025 19.015 23.179 1.00 33.55 ? 195 ASN A O 1 ATOM 1458 C CB . ASN A 1 179 ? 38.530 18.675 20.672 1.00 33.92 ? 195 ASN A CB 1 ATOM 1459 C CG . ASN A 1 179 ? 37.306 19.055 19.871 1.00 34.68 ? 195 ASN A CG 1 ATOM 1460 O OD1 . ASN A 1 179 ? 36.375 19.650 20.401 1.00 36.70 ? 195 ASN A OD1 1 ATOM 1461 N ND2 . ASN A 1 179 ? 37.303 18.719 18.585 1.00 33.85 ? 195 ASN A ND2 1 ATOM 1462 N N . ASN A 1 180 ? 41.671 19.814 21.844 1.00 33.62 ? 196 ASN A N 1 ATOM 1463 C CA . ASN A 1 180 ? 42.808 19.540 22.744 1.00 33.72 ? 196 ASN A CA 1 ATOM 1464 C C . ASN A 1 180 ? 43.144 18.064 22.970 1.00 33.37 ? 196 ASN A C 1 ATOM 1465 O O . ASN A 1 180 ? 43.719 17.700 23.995 1.00 33.29 ? 196 ASN A O 1 ATOM 1466 C CB . ASN A 1 180 ? 42.667 20.295 24.073 1.00 33.72 ? 196 ASN A CB 1 ATOM 1467 C CG . ASN A 1 180 ? 42.850 21.787 23.908 1.00 34.65 ? 196 ASN A CG 1 ATOM 1468 O OD1 . ASN A 1 180 ? 43.434 22.251 22.925 1.00 33.92 ? 196 ASN A OD1 1 ATOM 1469 N ND2 . ASN A 1 180 ? 42.359 22.550 24.870 1.00 35.48 ? 196 ASN A ND2 1 ATOM 1470 N N . PHE A 1 181 ? 42.769 17.225 22.007 1.00 32.89 ? 197 PHE A N 1 ATOM 1471 C CA . PHE A 1 181 ? 43.289 15.862 21.911 1.00 32.43 ? 197 PHE A CA 1 ATOM 1472 C C . PHE A 1 181 ? 44.553 15.930 21.067 1.00 32.11 ? 197 PHE A C 1 ATOM 1473 O O . PHE A 1 181 ? 44.693 16.841 20.255 1.00 32.04 ? 197 PHE A O 1 ATOM 1474 C CB . PHE A 1 181 ? 42.270 14.931 21.238 1.00 32.22 ? 197 PHE A CB 1 ATOM 1475 C CG . PHE A 1 181 ? 41.035 14.683 22.059 1.00 32.49 ? 197 PHE A CG 1 ATOM 1476 C CD1 . PHE A 1 181 ? 41.092 13.900 23.214 1.00 31.42 ? 197 PHE A CD1 1 ATOM 1477 C CD2 . PHE A 1 181 ? 39.812 15.225 21.674 1.00 32.21 ? 197 PHE A CD2 1 ATOM 1478 C CE1 . PHE A 1 181 ? 39.954 13.668 23.974 1.00 32.41 ? 197 PHE A CE1 1 ATOM 1479 C CE2 . PHE A 1 181 ? 38.659 14.995 22.427 1.00 32.56 ? 197 PHE A CE2 1 ATOM 1480 C CZ . PHE A 1 181 ? 38.728 14.218 23.579 1.00 32.78 ? 197 PHE A CZ 1 ATOM 1481 N N . THR A 1 182 ? 45.467 14.979 21.255 1.00 31.82 ? 198 THR A N 1 ATOM 1482 C CA . THR A 1 182 ? 46.721 14.969 20.500 1.00 31.78 ? 198 THR A CA 1 ATOM 1483 C C . THR A 1 182 ? 46.459 14.721 19.008 1.00 31.70 ? 198 THR A C 1 ATOM 1484 O O . THR A 1 182 ? 47.102 15.326 18.141 1.00 32.01 ? 198 THR A O 1 ATOM 1485 C CB . THR A 1 182 ? 47.696 13.924 21.058 1.00 31.80 ? 198 THR A CB 1 ATOM 1486 O OG1 . THR A 1 182 ? 47.920 14.184 22.452 1.00 32.47 ? 198 THR A OG1 1 ATOM 1487 C CG2 . THR A 1 182 ? 49.031 13.972 20.322 1.00 32.16 ? 198 THR A CG2 1 ATOM 1488 N N . SER A 1 183 ? 45.497 13.847 18.724 1.00 31.11 ? 199 SER A N 1 ATOM 1489 C CA . SER A 1 183 ? 45.145 13.483 17.351 1.00 30.52 ? 199 SER A CA 1 ATOM 1490 C C . SER A 1 183 ? 43.764 12.833 17.333 1.00 30.17 ? 199 SER A C 1 ATOM 1491 O O . SER A 1 183 ? 43.125 12.688 18.380 1.00 29.90 ? 199 SER A O 1 ATOM 1492 C CB . SER A 1 183 ? 46.186 12.520 16.775 1.00 30.32 ? 199 SER A CB 1 ATOM 1493 O OG . SER A 1 183 ? 46.020 11.218 17.308 1.00 30.19 ? 199 SER A OG 1 ATOM 1494 N N . GLY A 1 184 ? 43.303 12.446 16.144 1.00 29.69 ? 200 GLY A N 1 ATOM 1495 C CA . GLY A 1 184 ? 42.008 11.793 16.000 1.00 29.14 ? 200 GLY A CA 1 ATOM 1496 C C . GLY A 1 184 ? 41.928 10.443 16.686 1.00 29.08 ? 200 GLY A C 1 ATOM 1497 O O . GLY A 1 184 ? 40.833 9.967 17.001 1.00 28.78 ? 200 GLY A O 1 ATOM 1498 N N . ALA A 1 185 ? 43.086 9.823 16.906 1.00 28.95 ? 201 ALA A N 1 ATOM 1499 C CA . ALA A 1 185 ? 43.173 8.570 17.651 1.00 29.28 ? 201 ALA A CA 1 ATOM 1500 C C . ALA A 1 185 ? 42.681 8.766 19.092 1.00 29.59 ? 201 ALA A C 1 ATOM 1501 O O . ALA A 1 185 ? 41.852 8.001 19.576 1.00 29.70 ? 201 ALA A O 1 ATOM 1502 C CB . ALA A 1 185 ? 44.600 8.036 17.634 1.00 28.79 ? 201 ALA A CB 1 ATOM 1503 N N . GLU A 1 186 ? 43.178 9.806 19.755 1.00 30.16 ? 202 GLU A N 1 ATOM 1504 C CA . GLU A 1 186 ? 42.771 10.107 21.136 1.00 30.67 ? 202 GLU A CA 1 ATOM 1505 C C . GLU A 1 186 ? 41.317 10.573 21.196 1.00 30.58 ? 202 GLU A C 1 ATOM 1506 O O . GLU A 1 186 ? 40.595 10.247 22.137 1.00 30.47 ? 202 GLU A O 1 ATOM 1507 C CB . GLU A 1 186 ? 43.708 11.139 21.772 1.00 30.81 ? 202 GLU A CB 1 ATOM 1508 C CG . GLU A 1 186 ? 45.116 10.606 22.099 1.00 31.80 ? 202 GLU A CG 1 ATOM 1509 C CD . GLU A 1 186 ? 45.983 10.388 20.862 1.00 33.05 ? 202 GLU A CD 1 ATOM 1510 O OE1 . GLU A 1 186 ? 45.811 11.116 19.862 1.00 31.80 ? 202 GLU A OE1 1 ATOM 1511 O OE2 . GLU A 1 186 ? 46.845 9.487 20.894 1.00 34.57 ? 202 GLU A OE2 1 ATOM 1512 N N . ALA A 1 187 ? 40.883 11.311 20.173 1.00 30.89 ? 203 ALA A N 1 ATOM 1513 C CA . ALA A 1 187 ? 39.476 11.701 20.049 1.00 30.99 ? 203 ALA A CA 1 ATOM 1514 C C . ALA A 1 187 ? 38.562 10.474 20.019 1.00 30.98 ? 203 ALA A C 1 ATOM 1515 O O . ALA A 1 187 ? 37.571 10.418 20.751 1.00 31.41 ? 203 ALA A O 1 ATOM 1516 C CB . ALA A 1 187 ? 39.256 12.574 18.817 1.00 30.83 ? 203 ALA A CB 1 ATOM 1517 N N . TRP A 1 188 ? 38.914 9.489 19.194 1.00 30.97 ? 204 TRP A N 1 ATOM 1518 C CA . TRP A 1 188 ? 38.155 8.239 19.100 1.00 30.78 ? 204 TRP A CA 1 ATOM 1519 C C . TRP A 1 188 ? 38.184 7.460 20.410 1.00 30.89 ? 204 TRP A C 1 ATOM 1520 O O . TRP A 1 188 ? 37.158 6.937 20.859 1.00 30.79 ? 204 TRP A O 1 ATOM 1521 C CB . TRP A 1 188 ? 38.688 7.353 17.965 1.00 30.62 ? 204 TRP A CB 1 ATOM 1522 C CG . TRP A 1 188 ? 38.194 7.729 16.582 1.00 30.47 ? 204 TRP A CG 1 ATOM 1523 C CD1 . TRP A 1 188 ? 37.253 8.668 16.270 1.00 30.12 ? 204 TRP A CD1 1 ATOM 1524 C CD2 . TRP A 1 188 ? 38.588 7.130 15.341 1.00 29.71 ? 204 TRP A CD2 1 ATOM 1525 N NE1 . TRP A 1 188 ? 37.053 8.705 14.907 1.00 30.58 ? 204 TRP A NE1 1 ATOM 1526 C CE2 . TRP A 1 188 ? 37.858 7.769 14.316 1.00 29.87 ? 204 TRP A CE2 1 ATOM 1527 C CE3 . TRP A 1 188 ? 39.490 6.114 14.997 1.00 29.80 ? 204 TRP A CE3 1 ATOM 1528 C CZ2 . TRP A 1 188 ? 38.007 7.432 12.966 1.00 29.95 ? 204 TRP A CZ2 1 ATOM 1529 C CZ3 . TRP A 1 188 ? 39.638 5.778 13.654 1.00 29.58 ? 204 TRP A CZ3 1 ATOM 1530 C CH2 . TRP A 1 188 ? 38.898 6.436 12.658 1.00 29.53 ? 204 TRP A CH2 1 ATOM 1531 N N . LEU A 1 189 ? 39.367 7.391 21.015 1.00 30.66 ? 205 LEU A N 1 ATOM 1532 C CA . LEU A 1 189 ? 39.567 6.613 22.222 1.00 30.91 ? 205 LEU A CA 1 ATOM 1533 C C . LEU A 1 189 ? 38.827 7.185 23.427 1.00 31.17 ? 205 LEU A C 1 ATOM 1534 O O . LEU A 1 189 ? 38.478 6.450 24.344 1.00 31.18 ? 205 LEU A O 1 ATOM 1535 C CB . LEU A 1 189 ? 41.063 6.450 22.509 1.00 30.82 ? 205 LEU A CB 1 ATOM 1536 C CG . LEU A 1 189 ? 41.717 5.371 21.634 1.00 30.39 ? 205 LEU A CG 1 ATOM 1537 C CD1 . LEU A 1 189 ? 43.228 5.539 21.603 1.00 28.97 ? 205 LEU A CD1 1 ATOM 1538 C CD2 . LEU A 1 189 ? 41.310 3.970 22.108 1.00 28.93 ? 205 LEU A CD2 1 ATOM 1539 N N . ASP A 1 190 ? 38.579 8.491 23.399 1.00 31.85 ? 206 ASP A N 1 ATOM 1540 C CA . ASP A 1 190 ? 37.837 9.185 24.450 1.00 32.68 ? 206 ASP A CA 1 ATOM 1541 C C . ASP A 1 190 ? 36.450 8.570 24.688 1.00 32.86 ? 206 ASP A C 1 ATOM 1542 O O . ASP A 1 190 ? 35.949 8.593 25.810 1.00 32.91 ? 206 ASP A O 1 ATOM 1543 C CB . ASP A 1 190 ? 37.720 10.679 24.125 1.00 32.89 ? 206 ASP A CB 1 ATOM 1544 C CG . ASP A 1 190 ? 37.106 11.486 25.267 1.00 34.34 ? 206 ASP A CG 1 ATOM 1545 O OD1 . ASP A 1 190 ? 37.683 11.500 26.376 1.00 34.77 ? 206 ASP A OD1 1 ATOM 1546 O OD2 . ASP A 1 190 ? 36.035 12.099 25.050 1.00 36.48 ? 206 ASP A OD2 1 ATOM 1547 N N . GLU A 1 191 ? 35.855 7.997 23.638 1.00 32.93 ? 207 GLU A N 1 ATOM 1548 C CA . GLU A 1 191 ? 34.549 7.336 23.735 1.00 33.02 ? 207 GLU A CA 1 ATOM 1549 C C . GLU A 1 191 ? 34.508 6.170 24.728 1.00 32.62 ? 207 GLU A C 1 ATOM 1550 O O . GLU A 1 191 ? 33.428 5.761 25.156 1.00 32.43 ? 207 GLU A O 1 ATOM 1551 C CB . GLU A 1 191 ? 34.078 6.836 22.361 1.00 33.15 ? 207 GLU A CB 1 ATOM 1552 C CG . GLU A 1 191 ? 33.872 7.912 21.290 1.00 34.97 ? 207 GLU A CG 1 ATOM 1553 C CD . GLU A 1 191 ? 32.929 9.027 21.715 1.00 38.35 ? 207 GLU A CD 1 ATOM 1554 O OE1 . GLU A 1 191 ? 31.909 8.759 22.394 1.00 40.41 ? 207 GLU A OE1 1 ATOM 1555 O OE2 . GLU A 1 191 ? 33.211 10.187 21.362 1.00 40.18 ? 207 GLU A OE2 1 ATOM 1556 N N . TYR A 1 192 ? 35.673 5.626 25.072 1.00 32.37 ? 208 TYR A N 1 ATOM 1557 C CA . TYR A 1 192 ? 35.748 4.471 25.964 1.00 32.26 ? 208 TYR A CA 1 ATOM 1558 C C . TYR A 1 192 ? 36.034 4.834 27.428 1.00 32.62 ? 208 TYR A C 1 ATOM 1559 O O . TYR A 1 192 ? 36.086 3.952 28.285 1.00 32.40 ? 208 TYR A O 1 ATOM 1560 C CB . TYR A 1 192 ? 36.745 3.433 25.425 1.00 31.82 ? 208 TYR A CB 1 ATOM 1561 C CG . TYR A 1 192 ? 36.414 2.972 24.009 1.00 30.84 ? 208 TYR A CG 1 ATOM 1562 C CD1 . TYR A 1 192 ? 35.451 1.986 23.783 1.00 30.41 ? 208 TYR A CD1 1 ATOM 1563 C CD2 . TYR A 1 192 ? 37.044 3.540 22.901 1.00 30.05 ? 208 TYR A CD2 1 ATOM 1564 C CE1 . TYR A 1 192 ? 35.139 1.567 22.496 1.00 29.48 ? 208 TYR A CE1 1 ATOM 1565 C CE2 . TYR A 1 192 ? 36.737 3.125 21.603 1.00 29.49 ? 208 TYR A CE2 1 ATOM 1566 C CZ . TYR A 1 192 ? 35.778 2.143 21.412 1.00 29.76 ? 208 TYR A CZ 1 ATOM 1567 O OH . TYR A 1 192 ? 35.452 1.723 20.139 1.00 29.38 ? 208 TYR A OH 1 ATOM 1568 N N . GLU A 1 193 ? 36.206 6.129 27.701 1.00 33.14 ? 209 GLU A N 1 ATOM 1569 C CA . GLU A 1 193 ? 36.362 6.656 29.070 1.00 34.18 ? 209 GLU A CA 1 ATOM 1570 C C . GLU A 1 193 ? 37.313 5.830 29.930 1.00 33.95 ? 209 GLU A C 1 ATOM 1571 O O . GLU A 1 193 ? 36.961 5.442 31.050 1.00 33.83 ? 209 GLU A O 1 ATOM 1572 C CB . GLU A 1 193 ? 35.009 6.718 29.795 1.00 34.33 ? 209 GLU A CB 1 ATOM 1573 C CG . GLU A 1 193 ? 34.037 7.762 29.314 1.00 37.08 ? 209 GLU A CG 1 ATOM 1574 C CD . GLU A 1 193 ? 32.770 7.776 30.163 1.00 39.55 ? 209 GLU A CD 1 ATOM 1575 O OE1 . GLU A 1 193 ? 32.803 8.287 31.308 1.00 39.37 ? 209 GLU A OE1 1 ATOM 1576 O OE2 . GLU A 1 193 ? 31.743 7.259 29.685 1.00 40.81 ? 209 GLU A OE2 1 ATOM 1577 N N . ASP A 1 194 ? 38.504 5.547 29.411 1.00 33.82 ? 210 ASP A N 1 ATOM 1578 C CA . ASP A 1 194 ? 39.442 4.680 30.115 1.00 33.70 ? 210 ASP A CA 1 ATOM 1579 C C . ASP A 1 194 ? 40.851 4.893 29.569 1.00 33.71 ? 210 ASP A C 1 ATOM 1580 O O . ASP A 1 194 ? 41.140 4.544 28.419 1.00 33.12 ? 210 ASP A O 1 ATOM 1581 C CB . ASP A 1 194 ? 39.009 3.213 29.978 1.00 33.76 ? 210 ASP A CB 1 ATOM 1582 C CG . ASP A 1 194 ? 39.788 2.278 30.888 1.00 34.03 ? 210 ASP A CG 1 ATOM 1583 O OD1 . ASP A 1 194 ? 40.935 2.605 31.262 1.00 34.93 ? 210 ASP A OD1 1 ATOM 1584 O OD2 . ASP A 1 194 ? 39.254 1.199 31.217 1.00 34.31 ? 210 ASP A OD2 1 ATOM 1585 N N . ASP A 1 195 ? 41.725 5.465 30.397 1.00 33.32 ? 211 ASP A N 1 ATOM 1586 C CA . ASP A 1 195 ? 43.069 5.829 29.936 1.00 33.10 ? 211 ASP A CA 1 ATOM 1587 C C . ASP A 1 195 ? 44.038 4.642 29.736 1.00 32.65 ? 211 ASP A C 1 ATOM 1588 O O . ASP A 1 195 ? 45.156 4.833 29.260 1.00 33.08 ? 211 ASP A O 1 ATOM 1589 C CB . ASP A 1 195 ? 43.683 6.960 30.789 1.00 33.21 ? 211 ASP A CB 1 ATOM 1590 C CG . ASP A 1 195 ? 43.903 6.569 32.241 0.50 33.19 ? 211 ASP A CG 1 ATOM 1591 O OD1 . ASP A 1 195 ? 43.551 5.442 32.642 0.50 33.06 ? 211 ASP A OD1 1 ATOM 1592 O OD2 . ASP A 1 195 ? 44.438 7.410 32.991 0.50 34.35 ? 211 ASP A OD2 1 ATOM 1593 N N . THR A 1 196 ? 43.605 3.426 30.066 1.00 31.79 ? 212 THR A N 1 ATOM 1594 C CA . THR A 1 196 ? 44.409 2.227 29.790 1.00 31.33 ? 212 THR A CA 1 ATOM 1595 C C . THR A 1 196 ? 43.753 1.337 28.728 1.00 31.00 ? 212 THR A C 1 ATOM 1596 O O . THR A 1 196 ? 44.109 0.173 28.583 1.00 30.69 ? 212 THR A O 1 ATOM 1597 C CB . THR A 1 196 ? 44.658 1.369 31.063 1.00 31.48 ? 212 THR A CB 1 ATOM 1598 O OG1 . THR A 1 196 ? 43.409 0.869 31.558 1.00 31.48 ? 212 THR A OG1 1 ATOM 1599 C CG2 . THR A 1 196 ? 45.372 2.180 32.160 1.00 31.71 ? 212 THR A CG2 1 ATOM 1600 N N . PHE A 1 197 ? 42.804 1.891 27.980 1.00 30.79 ? 213 PHE A N 1 ATOM 1601 C CA . PHE A 1 197 ? 41.989 1.078 27.080 1.00 30.77 ? 213 PHE A CA 1 ATOM 1602 C C . PHE A 1 197 ? 42.803 0.366 26.004 1.00 30.76 ? 213 PHE A C 1 ATOM 1603 O O . PHE A 1 197 ? 42.535 -0.794 25.711 1.00 30.68 ? 213 PHE A O 1 ATOM 1604 C CB . PHE A 1 197 ? 40.859 1.897 26.454 1.00 30.40 ? 213 PHE A CB 1 ATOM 1605 C CG . PHE A 1 197 ? 39.703 1.062 25.976 1.00 29.78 ? 213 PHE A CG 1 ATOM 1606 C CD1 . PHE A 1 197 ? 38.853 0.447 26.887 1.00 28.94 ? 213 PHE A CD1 1 ATOM 1607 C CD2 . PHE A 1 197 ? 39.455 0.906 24.610 1.00 28.48 ? 213 PHE A CD2 1 ATOM 1608 C CE1 . PHE A 1 197 ? 37.776 -0.316 26.453 1.00 29.39 ? 213 PHE A CE1 1 ATOM 1609 C CE2 . PHE A 1 197 ? 38.382 0.142 24.163 1.00 28.03 ? 213 PHE A CE2 1 ATOM 1610 C CZ . PHE A 1 197 ? 37.539 -0.472 25.085 1.00 29.90 ? 213 PHE A CZ 1 ATOM 1611 N N . GLU A 1 198 ? 43.788 1.060 25.428 1.00 31.14 ? 214 GLU A N 1 ATOM 1612 C CA . GLU A 1 198 ? 44.651 0.464 24.395 1.00 31.78 ? 214 GLU A CA 1 ATOM 1613 C C . GLU A 1 198 ? 45.451 -0.711 24.950 1.00 31.68 ? 214 GLU A C 1 ATOM 1614 O O . GLU A 1 198 ? 45.468 -1.792 24.362 1.00 31.75 ? 214 GLU A O 1 ATOM 1615 C CB . GLU A 1 198 ? 45.619 1.497 23.813 1.00 31.77 ? 214 GLU A CB 1 ATOM 1616 C CG . GLU A 1 198 ? 44.996 2.522 22.904 1.00 32.15 ? 214 GLU A CG 1 ATOM 1617 C CD . GLU A 1 198 ? 45.909 3.718 22.698 1.00 33.23 ? 214 GLU A CD 1 ATOM 1618 O OE1 . GLU A 1 198 ? 46.052 4.529 23.649 1.00 32.87 ? 214 GLU A OE1 1 ATOM 1619 O OE2 . GLU A 1 198 ? 46.480 3.848 21.589 1.00 31.34 ? 214 GLU A OE2 1 ATOM 1620 N N . GLN A 1 199 ? 46.106 -0.493 26.089 1.00 31.75 ? 215 GLN A N 1 ATOM 1621 C CA . GLN A 1 199 ? 46.862 -1.560 26.752 1.00 31.90 ? 215 GLN A CA 1 ATOM 1622 C C . GLN A 1 199 ? 45.975 -2.762 27.068 1.00 31.28 ? 215 GLN A C 1 ATOM 1623 O O . GLN A 1 199 ? 46.376 -3.908 26.839 1.00 31.31 ? 215 GLN A O 1 ATOM 1624 C CB . GLN A 1 199 ? 47.584 -1.053 28.011 1.00 32.08 ? 215 GLN A CB 1 ATOM 1625 C CG . GLN A 1 199 ? 48.641 -2.031 28.549 1.00 33.72 ? 215 GLN A CG 1 ATOM 1626 C CD . GLN A 1 199 ? 49.661 -2.448 27.485 1.00 35.97 ? 215 GLN A CD 1 ATOM 1627 O OE1 . GLN A 1 199 ? 50.290 -1.604 26.842 1.00 36.72 ? 215 GLN A OE1 1 ATOM 1628 N NE2 . GLN A 1 199 ? 49.814 -3.755 27.294 1.00 35.92 ? 215 GLN A NE2 1 ATOM 1629 N N . GLN A 1 200 ? 44.764 -2.496 27.554 1.00 30.97 ? 216 GLN A N 1 ATOM 1630 C CA . GLN A 1 200 ? 43.799 -3.556 27.864 1.00 30.77 ? 216 GLN A CA 1 ATOM 1631 C C . GLN A 1 200 ? 43.511 -4.427 26.647 1.00 30.36 ? 216 GLN A C 1 ATOM 1632 O O . GLN A 1 200 ? 43.499 -5.652 26.736 1.00 29.92 ? 216 GLN A O 1 ATOM 1633 C CB . GLN A 1 200 ? 42.494 -2.959 28.378 1.00 30.95 ? 216 GLN A CB 1 ATOM 1634 C CG . GLN A 1 200 ? 42.530 -2.504 29.836 1.00 31.34 ? 216 GLN A CG 1 ATOM 1635 C CD . GLN A 1 200 ? 41.193 -1.947 30.266 1.00 31.95 ? 216 GLN A CD 1 ATOM 1636 O OE1 . GLN A 1 200 ? 40.163 -2.617 30.150 1.00 31.90 ? 216 GLN A OE1 1 ATOM 1637 N NE2 . GLN A 1 200 ? 41.194 -0.708 30.744 1.00 31.83 ? 216 GLN A NE2 1 ATOM 1638 N N . LEU A 1 201 ? 43.292 -3.780 25.507 1.00 30.11 ? 217 LEU A N 1 ATOM 1639 C CA . LEU A 1 201 ? 43.080 -4.500 24.257 1.00 30.01 ? 217 LEU A CA 1 ATOM 1640 C C . LEU A 1 201 ? 44.310 -5.278 23.803 1.00 30.01 ? 217 LEU A C 1 ATOM 1641 O O . LEU A 1 201 ? 44.175 -6.411 23.352 1.00 30.41 ? 217 LEU A O 1 ATOM 1642 C CB . LEU A 1 201 ? 42.572 -3.561 23.159 1.00 29.70 ? 217 LEU A CB 1 ATOM 1643 C CG . LEU A 1 201 ? 41.134 -3.077 23.371 1.00 29.32 ? 217 LEU A CG 1 ATOM 1644 C CD1 . LEU A 1 201 ? 40.803 -1.953 22.414 1.00 30.23 ? 217 LEU A CD1 1 ATOM 1645 C CD2 . LEU A 1 201 ? 40.130 -4.220 23.238 1.00 28.02 ? 217 LEU A CD2 1 ATOM 1646 N N . GLU A 1 202 ? 45.501 -4.682 23.927 1.00 30.22 ? 218 GLU A N 1 ATOM 1647 C CA . GLU A 1 202 ? 46.747 -5.392 23.600 1.00 30.53 ? 218 GLU A CA 1 ATOM 1648 C C . GLU A 1 202 ? 46.867 -6.681 24.413 1.00 30.81 ? 218 GLU A C 1 ATOM 1649 O O . GLU A 1 202 ? 47.198 -7.735 23.868 1.00 30.72 ? 218 GLU A O 1 ATOM 1650 C CB . GLU A 1 202 ? 47.995 -4.519 23.835 1.00 30.65 ? 218 GLU A CB 1 ATOM 1651 C CG . GLU A 1 202 ? 48.129 -3.272 22.953 1.00 31.19 ? 218 GLU A CG 1 ATOM 1652 C CD . GLU A 1 202 ? 48.505 -3.571 21.499 1.00 31.96 ? 218 GLU A CD 1 ATOM 1653 O OE1 . GLU A 1 202 ? 48.682 -4.754 21.131 1.00 32.22 ? 218 GLU A OE1 1 ATOM 1654 O OE2 . GLU A 1 202 ? 48.626 -2.600 20.723 1.00 31.62 ? 218 GLU A OE2 1 ATOM 1655 N N . ASP A 1 203 ? 46.598 -6.585 25.720 1.00 30.79 ? 219 ASP A N 1 ATOM 1656 C CA . ASP A 1 203 ? 46.667 -7.736 26.614 1.00 30.86 ? 219 ASP A CA 1 ATOM 1657 C C . ASP A 1 203 ? 45.673 -8.835 26.218 1.00 30.50 ? 219 ASP A C 1 ATOM 1658 O O . ASP A 1 203 ? 46.039 -10.007 26.153 1.00 30.32 ? 219 ASP A O 1 ATOM 1659 C CB . ASP A 1 203 ? 46.443 -7.310 28.076 1.00 31.28 ? 219 ASP A CB 1 ATOM 1660 C CG . ASP A 1 203 ? 47.570 -6.442 28.617 1.00 33.06 ? 219 ASP A CG 1 ATOM 1661 O OD1 . ASP A 1 203 ? 48.603 -6.283 27.929 1.00 34.73 ? 219 ASP A OD1 1 ATOM 1662 O OD2 . ASP A 1 203 ? 47.423 -5.909 29.739 1.00 35.41 ? 219 ASP A OD2 1 ATOM 1663 N N . ILE A 1 204 ? 44.426 -8.459 25.946 1.00 30.24 ? 220 ILE A N 1 ATOM 1664 C CA . ILE A 1 204 ? 43.426 -9.436 25.500 1.00 30.33 ? 220 ILE A CA 1 ATOM 1665 C C . ILE A 1 204 ? 43.792 -10.006 24.121 1.00 30.36 ? 220 ILE A C 1 ATOM 1666 O O . ILE A 1 204 ? 43.698 -11.210 23.903 1.00 30.25 ? 220 ILE A O 1 ATOM 1667 C CB . ILE A 1 204 ? 41.988 -8.845 25.494 1.00 30.55 ? 220 ILE A CB 1 ATOM 1668 C CG1 . ILE A 1 204 ? 41.501 -8.618 26.934 1.00 30.83 ? 220 ILE A CG1 1 ATOM 1669 C CG2 . ILE A 1 204 ? 41.012 -9.761 24.735 1.00 30.24 ? 220 ILE A CG2 1 ATOM 1670 C CD1 . ILE A 1 204 ? 40.371 -7.608 27.046 1.00 31.33 ? 220 ILE A CD1 1 ATOM 1671 N N . PHE A 1 205 ? 44.222 -9.147 23.200 1.00 30.33 ? 221 PHE A N 1 ATOM 1672 C CA . PHE A 1 205 ? 44.604 -9.633 21.875 1.00 30.34 ? 221 PHE A CA 1 ATOM 1673 C C . PHE A 1 205 ? 45.755 -10.640 21.977 1.00 30.69 ? 221 PHE A C 1 ATOM 1674 O O . PHE A 1 205 ? 45.724 -11.682 21.333 1.00 30.57 ? 221 PHE A O 1 ATOM 1675 C CB . PHE A 1 205 ? 44.946 -8.492 20.917 1.00 29.99 ? 221 PHE A CB 1 ATOM 1676 C CG . PHE A 1 205 ? 45.329 -8.968 19.538 1.00 30.14 ? 221 PHE A CG 1 ATOM 1677 C CD1 . PHE A 1 205 ? 44.370 -9.512 18.690 1.00 30.43 ? 221 PHE A CD1 1 ATOM 1678 C CD2 . PHE A 1 205 ? 46.652 -8.913 19.109 1.00 29.94 ? 221 PHE A CD2 1 ATOM 1679 C CE1 . PHE A 1 205 ? 44.719 -9.983 17.412 1.00 31.42 ? 221 PHE A CE1 1 ATOM 1680 C CE2 . PHE A 1 205 ? 47.012 -9.379 17.834 1.00 30.81 ? 221 PHE A CE2 1 ATOM 1681 C CZ . PHE A 1 205 ? 46.041 -9.915 16.988 1.00 30.36 ? 221 PHE A CZ 1 ATOM 1682 N N . ALA A 1 206 ? 46.745 -10.338 22.817 1.00 31.41 ? 222 ALA A N 1 ATOM 1683 C CA . ALA A 1 206 ? 47.883 -11.244 23.039 1.00 31.87 ? 222 ALA A CA 1 ATOM 1684 C C . ALA A 1 206 ? 47.481 -12.635 23.549 1.00 32.15 ? 222 ALA A C 1 ATOM 1685 O O . ALA A 1 206 ? 48.117 -13.625 23.190 1.00 32.46 ? 222 ALA A O 1 ATOM 1686 C CB . ALA A 1 206 ? 48.915 -10.604 23.972 1.00 31.98 ? 222 ALA A CB 1 ATOM 1687 N N . ASP A 1 207 ? 46.427 -12.708 24.366 1.00 32.45 ? 223 ASP A N 1 ATOM 1688 C CA . ASP A 1 207 ? 45.920 -13.988 24.886 1.00 32.92 ? 223 ASP A CA 1 ATOM 1689 C C . ASP A 1 207 ? 45.238 -14.847 23.814 1.00 32.87 ? 223 ASP A C 1 ATOM 1690 O O . ASP A 1 207 ? 45.329 -16.074 23.855 1.00 32.89 ? 223 ASP A O 1 ATOM 1691 C CB . ASP A 1 207 ? 44.938 -13.767 26.049 1.00 32.98 ? 223 ASP A CB 1 ATOM 1692 C CG . ASP A 1 207 ? 45.609 -13.198 27.301 1.00 34.38 ? 223 ASP A CG 1 ATOM 1693 O OD1 . ASP A 1 207 ? 46.824 -13.413 27.490 1.00 35.50 ? 223 ASP A OD1 1 ATOM 1694 O OD2 . ASP A 1 207 ? 44.912 -12.533 28.105 1.00 35.78 ? 223 ASP A OD2 1 ATOM 1695 N N . ILE A 1 208 ? 44.548 -14.203 22.874 1.00 32.88 ? 224 ILE A N 1 ATOM 1696 C CA . ILE A 1 208 ? 43.793 -14.911 21.824 1.00 33.36 ? 224 ILE A CA 1 ATOM 1697 C C . ILE A 1 208 ? 44.628 -15.152 20.555 1.00 33.16 ? 224 ILE A C 1 ATOM 1698 O O . ILE A 1 208 ? 44.292 -16.010 19.734 1.00 33.14 ? 224 ILE A O 1 ATOM 1699 C CB . ILE A 1 208 ? 42.471 -14.156 21.441 1.00 33.34 ? 224 ILE A CB 1 ATOM 1700 C CG1 . ILE A 1 208 ? 41.741 -13.610 22.679 1.00 35.28 ? 224 ILE A CG1 1 ATOM 1701 C CG2 . ILE A 1 208 ? 41.531 -15.046 20.629 1.00 33.94 ? 224 ILE A CG2 1 ATOM 1702 C CD1 . ILE A 1 208 ? 41.312 -14.659 23.710 1.00 38.30 ? 224 ILE A CD1 1 ATOM 1703 N N . ARG A 1 209 ? 45.709 -14.391 20.403 1.00 33.18 ? 225 ARG A N 1 ATOM 1704 C CA . ARG A 1 209 ? 46.562 -14.466 19.209 1.00 33.32 ? 225 ARG A CA 1 ATOM 1705 C C . ARG A 1 209 ? 47.096 -15.877 18.877 1.00 33.10 ? 225 ARG A C 1 ATOM 1706 O O . ARG A 1 209 ? 47.076 -16.265 17.707 1.00 33.43 ? 225 ARG A O 1 ATOM 1707 C CB . ARG A 1 209 ? 47.706 -13.441 19.293 1.00 33.39 ? 225 ARG A CB 1 ATOM 1708 C CG . ARG A 1 209 ? 48.334 -13.073 17.945 1.00 34.23 ? 225 ARG A CG 1 ATOM 1709 C CD . ARG A 1 209 ? 49.386 -11.987 18.109 1.00 35.24 ? 225 ARG A CD 1 ATOM 1710 N NE . ARG A 1 209 ? 49.912 -11.523 16.820 1.00 35.81 ? 225 ARG A NE 1 ATOM 1711 C CZ . ARG A 1 209 ? 50.620 -10.408 16.650 1.00 35.93 ? 225 ARG A CZ 1 ATOM 1712 N NH1 . ARG A 1 209 ? 50.883 -9.620 17.689 1.00 35.39 ? 225 ARG A NH1 1 ATOM 1713 N NH2 . ARG A 1 209 ? 51.058 -10.074 15.439 1.00 34.70 ? 225 ARG A NH2 1 ATOM 1714 N N . PRO A 1 210 ? 47.565 -16.651 19.890 1.00 32.81 ? 226 PRO A N 1 ATOM 1715 C CA . PRO A 1 210 ? 48.010 -18.022 19.586 1.00 32.44 ? 226 PRO A CA 1 ATOM 1716 C C . PRO A 1 210 ? 46.933 -18.896 18.940 1.00 32.36 ? 226 PRO A C 1 ATOM 1717 O O . PRO A 1 210 ? 47.240 -19.674 18.024 1.00 32.13 ? 226 PRO A O 1 ATOM 1718 C CB . PRO A 1 210 ? 48.404 -18.581 20.965 1.00 32.56 ? 226 PRO A CB 1 ATOM 1719 C CG . PRO A 1 210 ? 48.786 -17.365 21.761 1.00 32.43 ? 226 PRO A CG 1 ATOM 1720 C CD . PRO A 1 210 ? 47.791 -16.321 21.315 1.00 32.78 ? 226 PRO A CD 1 ATOM 1721 N N . LEU A 1 211 ? 45.686 -18.767 19.399 1.00 31.81 ? 227 LEU A N 1 ATOM 1722 C CA . LEU A 1 211 ? 44.569 -19.472 18.761 1.00 31.64 ? 227 LEU A CA 1 ATOM 1723 C C . LEU A 1 211 ? 44.396 -19.051 17.294 1.00 31.29 ? 227 LEU A C 1 ATOM 1724 O O . LEU A 1 211 ? 44.182 -19.905 16.427 1.00 31.04 ? 227 LEU A O 1 ATOM 1725 C CB . LEU A 1 211 ? 43.255 -19.282 19.534 1.00 31.33 ? 227 LEU A CB 1 ATOM 1726 C CG . LEU A 1 211 ? 42.012 -19.984 18.965 1.00 31.86 ? 227 LEU A CG 1 ATOM 1727 C CD1 . LEU A 1 211 ? 42.216 -21.500 18.827 1.00 32.22 ? 227 LEU A CD1 1 ATOM 1728 C CD2 . LEU A 1 211 ? 40.767 -19.681 19.804 1.00 31.75 ? 227 LEU A CD2 1 ATOM 1729 N N . TYR A 1 212 ? 44.497 -17.749 17.019 1.00 31.17 ? 228 TYR A N 1 ATOM 1730 C CA . TYR A 1 212 ? 44.402 -17.266 15.638 1.00 31.53 ? 228 TYR A CA 1 ATOM 1731 C C . TYR A 1 212 ? 45.471 -17.902 14.753 1.00 31.75 ? 228 TYR A C 1 ATOM 1732 O O . TYR A 1 212 ? 45.200 -18.298 13.610 1.00 32.46 ? 228 TYR A O 1 ATOM 1733 C CB . TYR A 1 212 ? 44.483 -15.728 15.536 1.00 31.32 ? 228 TYR A CB 1 ATOM 1734 C CG . TYR A 1 212 ? 44.537 -15.269 14.080 1.00 31.25 ? 228 TYR A CG 1 ATOM 1735 C CD1 . TYR A 1 212 ? 43.418 -15.383 13.259 1.00 31.22 ? 228 TYR A CD1 1 ATOM 1736 C CD2 . TYR A 1 212 ? 45.716 -14.775 13.519 1.00 29.76 ? 228 TYR A CD2 1 ATOM 1737 C CE1 . TYR A 1 212 ? 43.461 -15.003 11.913 1.00 31.51 ? 228 TYR A CE1 1 ATOM 1738 C CE2 . TYR A 1 212 ? 45.767 -14.385 12.173 1.00 30.83 ? 228 TYR A CE2 1 ATOM 1739 C CZ . TYR A 1 212 ? 44.636 -14.506 11.380 1.00 30.43 ? 228 TYR A CZ 1 ATOM 1740 O OH . TYR A 1 212 ? 44.655 -14.117 10.062 1.00 31.42 ? 228 TYR A OH 1 ATOM 1741 N N . GLN A 1 213 ? 46.687 -17.989 15.282 1.00 31.83 ? 229 GLN A N 1 ATOM 1742 C CA . GLN A 1 213 ? 47.814 -18.524 14.525 1.00 32.00 ? 229 GLN A CA 1 ATOM 1743 C C . GLN A 1 213 ? 47.618 -19.996 14.164 1.00 31.70 ? 229 GLN A C 1 ATOM 1744 O O . GLN A 1 213 ? 48.018 -20.427 13.082 1.00 31.53 ? 229 GLN A O 1 ATOM 1745 C CB . GLN A 1 213 ? 49.141 -18.261 15.253 1.00 32.32 ? 229 GLN A CB 1 ATOM 1746 C CG . GLN A 1 213 ? 49.507 -16.770 15.286 0.50 33.82 ? 229 GLN A CG 1 ATOM 1747 C CD . GLN A 1 213 ? 50.987 -16.513 15.092 0.50 36.51 ? 229 GLN A CD 1 ATOM 1748 O OE1 . GLN A 1 213 ? 51.407 -15.988 14.062 0.50 36.95 ? 229 GLN A OE1 1 ATOM 1749 N NE2 . GLN A 1 213 ? 51.790 -16.887 16.082 1.00 40.00 ? 229 GLN A NE2 1 ATOM 1750 N N . GLN A 1 214 ? 46.970 -20.752 15.051 1.00 31.19 ? 230 GLN A N 1 ATOM 1751 C CA . GLN A 1 214 ? 46.617 -22.148 14.761 1.00 30.63 ? 230 GLN A CA 1 ATOM 1752 C C . GLN A 1 214 ? 45.579 -22.258 13.640 1.00 30.51 ? 230 GLN A C 1 ATOM 1753 O O . GLN A 1 214 ? 45.690 -23.123 12.756 1.00 29.83 ? 230 GLN A O 1 ATOM 1754 C CB . GLN A 1 214 ? 46.109 -22.853 16.025 1.00 30.77 ? 230 GLN A CB 1 ATOM 1755 C CG . GLN A 1 214 ? 47.141 -22.952 17.157 1.00 30.31 ? 230 GLN A CG 1 ATOM 1756 C CD . GLN A 1 214 ? 48.295 -23.897 16.839 1.00 30.09 ? 230 GLN A CD 1 ATOM 1757 O OE1 . GLN A 1 214 ? 48.089 -25.021 16.385 1.00 30.25 ? 230 GLN A OE1 1 ATOM 1758 N NE2 . GLN A 1 214 ? 49.515 -23.443 17.093 1.00 30.14 ? 230 GLN A NE2 1 ATOM 1759 N N . ILE A 1 215 ? 44.574 -21.378 13.687 1.00 30.18 ? 231 ILE A N 1 ATOM 1760 C CA . ILE A 1 215 ? 43.514 -21.349 12.689 1.00 30.21 ? 231 ILE A CA 1 ATOM 1761 C C . ILE A 1 215 ? 44.094 -20.945 11.338 1.00 30.08 ? 231 ILE A C 1 ATOM 1762 O O . ILE A 1 215 ? 43.789 -21.564 10.327 1.00 29.97 ? 231 ILE A O 1 ATOM 1763 C CB . ILE A 1 215 ? 42.377 -20.367 13.083 1.00 30.19 ? 231 ILE A CB 1 ATOM 1764 C CG1 . ILE A 1 215 ? 41.689 -20.843 14.365 1.00 30.63 ? 231 ILE A CG1 1 ATOM 1765 C CG2 . ILE A 1 215 ? 41.358 -20.232 11.953 1.00 29.80 ? 231 ILE A CG2 1 ATOM 1766 C CD1 . ILE A 1 215 ? 40.951 -19.765 15.119 1.00 30.24 ? 231 ILE A CD1 1 ATOM 1767 N N . HIS A 1 216 ? 44.913 -19.894 11.347 1.00 30.32 ? 232 HIS A N 1 ATOM 1768 C CA . HIS A 1 216 ? 45.597 -19.399 10.151 1.00 30.54 ? 232 HIS A CA 1 ATOM 1769 C C . HIS A 1 216 ? 46.406 -20.515 9.492 1.00 30.62 ? 232 HIS A C 1 ATOM 1770 O O . HIS A 1 216 ? 46.291 -20.748 8.281 1.00 30.61 ? 232 HIS A O 1 ATOM 1771 C CB . HIS A 1 216 ? 46.489 -18.207 10.521 1.00 30.56 ? 232 HIS A CB 1 ATOM 1772 C CG . HIS A 1 216 ? 47.353 -17.709 9.401 1.00 31.10 ? 232 HIS A CG 1 ATOM 1773 N ND1 . HIS A 1 216 ? 48.484 -18.376 8.978 1.00 31.55 ? 232 HIS A ND1 1 ATOM 1774 C CD2 . HIS A 1 216 ? 47.267 -16.593 8.640 1.00 30.10 ? 232 HIS A CD2 1 ATOM 1775 C CE1 . HIS A 1 216 ? 49.040 -17.705 7.984 1.00 32.19 ? 232 HIS A CE1 1 ATOM 1776 N NE2 . HIS A 1 216 ? 48.325 -16.617 7.764 1.00 31.84 ? 232 HIS A NE2 1 ATOM 1777 N N . GLY A 1 217 ? 47.206 -21.210 10.301 1.00 30.41 ? 233 GLY A N 1 ATOM 1778 C CA . GLY A 1 217 ? 48.058 -22.300 9.826 1.00 30.07 ? 233 GLY A CA 1 ATOM 1779 C C . GLY A 1 217 ? 47.285 -23.452 9.220 1.00 30.22 ? 233 GLY A C 1 ATOM 1780 O O . GLY A 1 217 ? 47.653 -23.973 8.153 1.00 29.89 ? 233 GLY A O 1 ATOM 1781 N N . TYR A 1 218 ? 46.204 -23.845 9.892 1.00 30.14 ? 234 TYR A N 1 ATOM 1782 C CA . TYR A 1 218 ? 45.346 -24.918 9.407 1.00 30.41 ? 234 TYR A CA 1 ATOM 1783 C C . TYR A 1 218 ? 44.637 -24.528 8.106 1.00 30.56 ? 234 TYR A C 1 ATOM 1784 O O . TYR A 1 218 ? 44.528 -25.348 7.186 1.00 30.50 ? 234 TYR A O 1 ATOM 1785 C CB . TYR A 1 218 ? 44.323 -25.342 10.470 1.00 30.55 ? 234 TYR A CB 1 ATOM 1786 C CG . TYR A 1 218 ? 43.506 -26.542 10.052 1.00 30.93 ? 234 TYR A CG 1 ATOM 1787 C CD1 . TYR A 1 218 ? 44.010 -27.831 10.200 1.00 31.84 ? 234 TYR A CD1 1 ATOM 1788 C CD2 . TYR A 1 218 ? 42.239 -26.388 9.484 1.00 31.42 ? 234 TYR A CD2 1 ATOM 1789 C CE1 . TYR A 1 218 ? 43.274 -28.944 9.805 1.00 33.08 ? 234 TYR A CE1 1 ATOM 1790 C CE2 . TYR A 1 218 ? 41.495 -27.495 9.083 1.00 33.11 ? 234 TYR A CE2 1 ATOM 1791 C CZ . TYR A 1 218 ? 42.021 -28.768 9.251 1.00 33.80 ? 234 TYR A CZ 1 ATOM 1792 O OH . TYR A 1 218 ? 41.301 -29.872 8.857 1.00 35.08 ? 234 TYR A OH 1 ATOM 1793 N N . VAL A 1 219 ? 44.156 -23.286 8.038 1.00 30.49 ? 235 VAL A N 1 ATOM 1794 C CA . VAL A 1 219 ? 43.486 -22.791 6.829 1.00 30.95 ? 235 VAL A CA 1 ATOM 1795 C C . VAL A 1 219 ? 44.451 -22.806 5.639 1.00 31.10 ? 235 VAL A C 1 ATOM 1796 O O . VAL A 1 219 ? 44.104 -23.301 4.570 1.00 31.57 ? 235 VAL A O 1 ATOM 1797 C CB . VAL A 1 219 ? 42.811 -21.403 7.042 1.00 30.67 ? 235 VAL A CB 1 ATOM 1798 C CG1 . VAL A 1 219 ? 42.366 -20.783 5.701 1.00 30.69 ? 235 VAL A CG1 1 ATOM 1799 C CG2 . VAL A 1 219 ? 41.603 -21.548 7.970 1.00 29.76 ? 235 VAL A CG2 1 ATOM 1800 N N . ARG A 1 220 ? 45.658 -22.283 5.847 1.00 31.51 ? 236 ARG A N 1 ATOM 1801 C CA . ARG A 1 220 ? 46.722 -22.290 4.832 1.00 31.74 ? 236 ARG A CA 1 ATOM 1802 C C . ARG A 1 220 ? 47.025 -23.711 4.338 1.00 31.92 ? 236 ARG A C 1 ATOM 1803 O O . ARG A 1 220 ? 47.120 -23.958 3.129 1.00 31.74 ? 236 ARG A O 1 ATOM 1804 C CB . ARG A 1 220 ? 47.985 -21.607 5.382 1.00 31.59 ? 236 ARG A CB 1 ATOM 1805 C CG . ARG A 1 220 ? 49.208 -21.603 4.443 1.00 31.47 ? 236 ARG A CG 1 ATOM 1806 C CD . ARG A 1 220 ? 50.325 -20.728 5.001 1.00 31.27 ? 236 ARG A CD 1 ATOM 1807 N NE . ARG A 1 220 ? 50.740 -21.123 6.353 1.00 30.40 ? 236 ARG A NE 1 ATOM 1808 C CZ . ARG A 1 220 ? 51.591 -20.438 7.116 1.00 29.63 ? 236 ARG A CZ 1 ATOM 1809 N NH1 . ARG A 1 220 ? 52.131 -19.305 6.677 1.00 29.27 ? 236 ARG A NH1 1 ATOM 1810 N NH2 . ARG A 1 220 ? 51.905 -20.886 8.330 1.00 29.34 ? 236 ARG A NH2 1 ATOM 1811 N N . PHE A 1 221 ? 47.162 -24.639 5.282 1.00 32.07 ? 237 PHE A N 1 ATOM 1812 C CA . PHE A 1 221 ? 47.339 -26.058 4.970 1.00 32.62 ? 237 PHE A CA 1 ATOM 1813 C C . PHE A 1 221 ? 46.236 -26.588 4.038 1.00 32.70 ? 237 PHE A C 1 ATOM 1814 O O . PHE A 1 221 ? 46.526 -27.239 3.029 1.00 32.43 ? 237 PHE A O 1 ATOM 1815 C CB . PHE A 1 221 ? 47.425 -26.875 6.269 1.00 32.49 ? 237 PHE A CB 1 ATOM 1816 C CG . PHE A 1 221 ? 47.180 -28.357 6.096 1.00 33.56 ? 237 PHE A CG 1 ATOM 1817 C CD1 . PHE A 1 221 ? 48.064 -29.152 5.358 1.00 33.76 ? 237 PHE A CD1 1 ATOM 1818 C CD2 . PHE A 1 221 ? 46.082 -28.965 6.711 1.00 33.84 ? 237 PHE A CD2 1 ATOM 1819 C CE1 . PHE A 1 221 ? 47.840 -30.526 5.215 1.00 34.05 ? 237 PHE A CE1 1 ATOM 1820 C CE2 . PHE A 1 221 ? 45.849 -30.337 6.575 1.00 34.12 ? 237 PHE A CE2 1 ATOM 1821 C CZ . PHE A 1 221 ? 46.732 -31.120 5.824 1.00 34.69 ? 237 PHE A CZ 1 ATOM 1822 N N . ARG A 1 222 ? 44.982 -26.285 4.369 1.00 32.60 ? 238 ARG A N 1 ATOM 1823 C CA . ARG A 1 222 ? 43.852 -26.778 3.593 1.00 33.02 ? 238 ARG A CA 1 ATOM 1824 C C . ARG A 1 222 ? 43.733 -26.097 2.228 1.00 33.21 ? 238 ARG A C 1 ATOM 1825 O O . ARG A 1 222 ? 43.368 -26.740 1.245 1.00 33.35 ? 238 ARG A O 1 ATOM 1826 C CB . ARG A 1 222 ? 42.549 -26.672 4.400 1.00 32.89 ? 238 ARG A CB 1 ATOM 1827 C CG . ARG A 1 222 ? 42.502 -27.612 5.618 1.00 33.47 ? 238 ARG A CG 1 ATOM 1828 C CD . ARG A 1 222 ? 42.383 -29.089 5.209 1.00 34.22 ? 238 ARG A CD 1 ATOM 1829 N NE . ARG A 1 222 ? 41.151 -29.341 4.460 1.00 35.12 ? 238 ARG A NE 1 ATOM 1830 C CZ . ARG A 1 222 ? 39.982 -29.633 5.025 1.00 36.84 ? 238 ARG A CZ 1 ATOM 1831 N NH1 . ARG A 1 222 ? 39.883 -29.728 6.350 1.00 37.01 ? 238 ARG A NH1 1 ATOM 1832 N NH2 . ARG A 1 222 ? 38.912 -29.835 4.269 1.00 37.37 ? 238 ARG A NH2 1 ATOM 1833 N N . LEU A 1 223 ? 44.061 -24.809 2.173 1.00 33.21 ? 239 LEU A N 1 ATOM 1834 C CA . LEU A 1 223 ? 44.074 -24.071 0.908 1.00 33.67 ? 239 LEU A CA 1 ATOM 1835 C C . LEU A 1 223 ? 45.146 -24.596 -0.056 1.00 33.92 ? 239 LEU A C 1 ATOM 1836 O O . LEU A 1 223 ? 44.934 -24.613 -1.274 1.00 33.95 ? 239 LEU A O 1 ATOM 1837 C CB . LEU A 1 223 ? 44.241 -22.566 1.149 1.00 33.26 ? 239 LEU A CB 1 ATOM 1838 C CG . LEU A 1 223 ? 43.028 -21.829 1.743 1.00 33.13 ? 239 LEU A CG 1 ATOM 1839 C CD1 . LEU A 1 223 ? 43.387 -20.391 2.057 1.00 32.58 ? 239 LEU A CD1 1 ATOM 1840 C CD2 . LEU A 1 223 ? 41.811 -21.890 0.818 1.00 32.70 ? 239 LEU A CD2 1 ATOM 1841 N N . ARG A 1 224 ? 46.284 -25.020 0.499 1.00 34.27 ? 240 ARG A N 1 ATOM 1842 C CA . ARG A 1 224 ? 47.351 -25.648 -0.281 1.00 34.85 ? 240 ARG A CA 1 ATOM 1843 C C . ARG A 1 224 ? 46.854 -26.899 -1.006 1.00 35.40 ? 240 ARG A C 1 ATOM 1844 O O . ARG A 1 224 ? 47.149 -27.095 -2.184 1.00 35.81 ? 240 ARG A O 1 ATOM 1845 C CB . ARG A 1 224 ? 48.557 -25.983 0.603 1.00 34.53 ? 240 ARG A CB 1 ATOM 1846 C CG . ARG A 1 224 ? 49.409 -24.776 0.966 1.00 34.41 ? 240 ARG A CG 1 ATOM 1847 C CD . ARG A 1 224 ? 50.545 -25.153 1.896 1.00 34.55 ? 240 ARG A CD 1 ATOM 1848 N NE . ARG A 1 224 ? 51.505 -26.040 1.237 1.00 34.34 ? 240 ARG A NE 1 ATOM 1849 C CZ . ARG A 1 224 ? 52.226 -26.961 1.868 1.00 33.70 ? 240 ARG A CZ 1 ATOM 1850 N NH1 . ARG A 1 224 ? 52.101 -27.130 3.185 1.00 31.95 ? 240 ARG A NH1 1 ATOM 1851 N NH2 . ARG A 1 224 ? 53.067 -27.718 1.181 1.00 32.13 ? 240 ARG A NH2 1 ATOM 1852 N N . LYS A 1 225 ? 46.082 -27.724 -0.304 1.00 35.82 ? 241 LYS A N 1 ATOM 1853 C CA . LYS A 1 225 ? 45.519 -28.943 -0.882 1.00 36.39 ? 241 LYS A CA 1 ATOM 1854 C C . LYS A 1 225 ? 44.510 -28.647 -1.991 1.00 36.42 ? 241 LYS A C 1 ATOM 1855 O O . LYS A 1 225 ? 44.413 -29.403 -2.969 1.00 36.58 ? 241 LYS A O 1 ATOM 1856 C CB . LYS A 1 225 ? 44.883 -29.811 0.205 1.00 36.69 ? 241 LYS A CB 1 ATOM 1857 C CG . LYS A 1 225 ? 45.890 -30.342 1.222 1.00 38.36 ? 241 LYS A CG 1 ATOM 1858 C CD . LYS A 1 225 ? 45.213 -30.962 2.438 1.00 41.62 ? 241 LYS A CD 1 ATOM 1859 C CE . LYS A 1 225 ? 44.826 -32.413 2.201 1.00 43.93 ? 241 LYS A CE 1 ATOM 1860 N NZ . LYS A 1 225 ? 44.456 -33.063 3.500 1.00 45.91 ? 241 LYS A NZ 1 ATOM 1861 N N . HIS A 1 226 ? 43.773 -27.542 -1.847 1.00 36.01 ? 242 HIS A N 1 ATOM 1862 C CA . HIS A 1 226 ? 42.758 -27.159 -2.830 1.00 35.47 ? 242 HIS A CA 1 ATOM 1863 C C . HIS A 1 226 ? 43.353 -26.482 -4.066 1.00 35.36 ? 242 HIS A C 1 ATOM 1864 O O . HIS A 1 226 ? 43.040 -26.859 -5.202 1.00 35.46 ? 242 HIS A O 1 ATOM 1865 C CB . HIS A 1 226 ? 41.688 -26.263 -2.188 1.00 35.35 ? 242 HIS A CB 1 ATOM 1866 C CG . HIS A 1 226 ? 40.514 -25.989 -3.078 1.00 34.99 ? 242 HIS A CG 1 ATOM 1867 N ND1 . HIS A 1 226 ? 39.397 -26.795 -3.103 1.00 34.31 ? 242 HIS A ND1 1 ATOM 1868 C CD2 . HIS A 1 226 ? 40.291 -25.007 -3.985 1.00 34.18 ? 242 HIS A CD2 1 ATOM 1869 C CE1 . HIS A 1 226 ? 38.534 -26.319 -3.983 1.00 33.82 ? 242 HIS A CE1 1 ATOM 1870 N NE2 . HIS A 1 226 ? 39.051 -25.234 -4.531 1.00 33.41 ? 242 HIS A NE2 1 ATOM 1871 N N . TYR A 1 227 ? 44.195 -25.476 -3.847 1.00 35.22 ? 243 TYR A N 1 ATOM 1872 C CA . TYR A 1 227 ? 44.709 -24.664 -4.949 1.00 35.04 ? 243 TYR A CA 1 ATOM 1873 C C . TYR A 1 227 ? 46.069 -25.139 -5.472 1.00 35.13 ? 243 TYR A C 1 ATOM 1874 O O . TYR A 1 227 ? 46.450 -24.803 -6.600 1.00 34.93 ? 243 TYR A O 1 ATOM 1875 C CB . TYR A 1 227 ? 44.774 -23.185 -4.560 1.00 34.82 ? 243 TYR A CB 1 ATOM 1876 C CG . TYR A 1 227 ? 43.428 -22.478 -4.510 1.00 34.58 ? 243 TYR A CG 1 ATOM 1877 C CD1 . TYR A 1 227 ? 42.785 -22.066 -5.684 1.00 34.12 ? 243 TYR A CD1 1 ATOM 1878 C CD2 . TYR A 1 227 ? 42.809 -22.206 -3.289 1.00 34.07 ? 243 TYR A CD2 1 ATOM 1879 C CE1 . TYR A 1 227 ? 41.554 -21.413 -5.642 1.00 34.08 ? 243 TYR A CE1 1 ATOM 1880 C CE2 . TYR A 1 227 ? 41.573 -21.550 -3.233 1.00 34.00 ? 243 TYR A CE2 1 ATOM 1881 C CZ . TYR A 1 227 ? 40.956 -21.156 -4.409 1.00 34.46 ? 243 TYR A CZ 1 ATOM 1882 O OH . TYR A 1 227 ? 39.741 -20.514 -4.358 1.00 34.05 ? 243 TYR A OH 1 ATOM 1883 N N . GLY A 1 228 ? 46.781 -25.920 -4.657 1.00 34.85 ? 244 GLY A N 1 ATOM 1884 C CA . GLY A 1 228 ? 48.146 -26.344 -4.973 1.00 34.90 ? 244 GLY A CA 1 ATOM 1885 C C . GLY A 1 228 ? 49.185 -25.352 -4.483 1.00 34.79 ? 244 GLY A C 1 ATOM 1886 O O . GLY A 1 228 ? 48.858 -24.210 -4.167 1.00 34.71 ? 244 GLY A O 1 ATOM 1887 N N . ASP A 1 229 ? 50.444 -25.785 -4.433 1.00 35.02 ? 245 ASP A N 1 ATOM 1888 C CA . ASP A 1 229 ? 51.532 -24.974 -3.874 1.00 35.42 ? 245 ASP A CA 1 ATOM 1889 C C . ASP A 1 229 ? 52.030 -23.828 -4.770 1.00 35.40 ? 245 ASP A C 1 ATOM 1890 O O . ASP A 1 229 ? 52.768 -22.960 -4.310 1.00 35.52 ? 245 ASP A O 1 ATOM 1891 C CB . ASP A 1 229 ? 52.699 -25.872 -3.426 1.00 35.80 ? 245 ASP A CB 1 ATOM 1892 C CG . ASP A 1 229 ? 52.453 -26.519 -2.063 1.00 36.94 ? 245 ASP A CG 1 ATOM 1893 O OD1 . ASP A 1 229 ? 51.318 -26.948 -1.784 1.00 38.54 ? 245 ASP A OD1 1 ATOM 1894 O OD2 . ASP A 1 229 ? 53.399 -26.593 -1.261 1.00 39.04 ? 245 ASP A OD2 1 ATOM 1895 N N . ALA A 1 230 ? 51.623 -23.813 -6.038 1.00 35.16 ? 246 ALA A N 1 ATOM 1896 C CA . ALA A 1 230 ? 51.944 -22.686 -6.917 1.00 35.07 ? 246 ALA A CA 1 ATOM 1897 C C . ALA A 1 230 ? 51.127 -21.437 -6.549 1.00 35.06 ? 246 ALA A C 1 ATOM 1898 O O . ALA A 1 230 ? 51.551 -20.313 -6.822 1.00 35.24 ? 246 ALA A O 1 ATOM 1899 C CB . ALA A 1 230 ? 51.731 -23.064 -8.384 1.00 34.95 ? 246 ALA A CB 1 ATOM 1900 N N . VAL A 1 231 ? 49.971 -21.649 -5.918 1.00 34.84 ? 247 VAL A N 1 ATOM 1901 C CA . VAL A 1 231 ? 49.065 -20.565 -5.516 1.00 34.59 ? 247 VAL A CA 1 ATOM 1902 C C . VAL A 1 231 ? 49.252 -20.184 -4.043 1.00 34.60 ? 247 VAL A C 1 ATOM 1903 O O . VAL A 1 231 ? 49.201 -19.002 -3.695 1.00 34.48 ? 247 VAL A O 1 ATOM 1904 C CB . VAL A 1 231 ? 47.575 -20.944 -5.770 1.00 34.63 ? 247 VAL A CB 1 ATOM 1905 C CG1 . VAL A 1 231 ? 46.635 -19.797 -5.388 1.00 34.10 ? 247 VAL A CG1 1 ATOM 1906 C CG2 . VAL A 1 231 ? 47.356 -21.337 -7.237 1.00 34.71 ? 247 VAL A CG2 1 ATOM 1907 N N . VAL A 1 232 ? 49.459 -21.188 -3.187 1.00 34.51 ? 248 VAL A N 1 ATOM 1908 C CA . VAL A 1 232 ? 49.608 -20.986 -1.740 1.00 34.59 ? 248 VAL A CA 1 ATOM 1909 C C . VAL A 1 232 ? 50.888 -21.638 -1.224 1.00 34.89 ? 248 VAL A C 1 ATOM 1910 O O . VAL A 1 232 ? 51.067 -22.855 -1.350 1.00 35.31 ? 248 VAL A O 1 ATOM 1911 C CB . VAL A 1 232 ? 48.410 -21.592 -0.960 1.00 34.56 ? 248 VAL A CB 1 ATOM 1912 C CG1 . VAL A 1 232 ? 48.501 -21.261 0.539 1.00 34.32 ? 248 VAL A CG1 1 ATOM 1913 C CG2 . VAL A 1 232 ? 47.086 -21.111 -1.535 1.00 33.86 ? 248 VAL A CG2 1 ATOM 1914 N N . SER A 1 233 ? 51.771 -20.838 -0.634 1.00 34.91 ? 249 SER A N 1 ATOM 1915 C CA . SER A 1 233 ? 52.990 -21.369 -0.030 1.00 35.06 ? 249 SER A CA 1 ATOM 1916 C C . SER A 1 233 ? 52.744 -21.806 1.410 1.00 34.80 ? 249 SER A C 1 ATOM 1917 O O . SER A 1 233 ? 51.804 -21.344 2.061 1.00 34.52 ? 249 SER A O 1 ATOM 1918 C CB . SER A 1 233 ? 54.128 -20.347 -0.089 1.00 35.23 ? 249 SER A CB 1 ATOM 1919 O OG . SER A 1 233 ? 53.964 -19.335 0.888 1.00 36.53 ? 249 SER A OG 1 ATOM 1920 N N . GLU A 1 234 ? 53.606 -22.693 1.895 1.00 34.58 ? 250 GLU A N 1 ATOM 1921 C CA . GLU A 1 234 ? 53.519 -23.208 3.256 1.00 34.25 ? 250 GLU A CA 1 ATOM 1922 C C . GLU A 1 234 ? 53.936 -22.160 4.282 1.00 34.05 ? 250 GLU A C 1 ATOM 1923 O O . GLU A 1 234 ? 53.387 -22.104 5.388 1.00 33.90 ? 250 GLU A O 1 ATOM 1924 C CB . GLU A 1 234 ? 54.405 -24.450 3.403 1.00 34.52 ? 250 GLU A CB 1 ATOM 1925 C CG . GLU A 1 234 ? 54.408 -25.057 4.815 1.00 34.83 ? 250 GLU A CG 1 ATOM 1926 C CD . GLU A 1 234 ? 55.239 -26.314 4.926 1.00 35.93 ? 250 GLU A CD 1 ATOM 1927 O OE1 . GLU A 1 234 ? 56.304 -26.389 4.277 1.00 37.50 ? 250 GLU A OE1 1 ATOM 1928 O OE2 . GLU A 1 234 ? 54.826 -27.237 5.661 1.00 36.44 ? 250 GLU A OE2 1 ATOM 1929 N N . THR A 1 235 ? 54.910 -21.338 3.909 1.00 33.62 ? 251 THR A N 1 ATOM 1930 C CA . THR A 1 235 ? 55.607 -20.490 4.867 1.00 33.77 ? 251 THR A CA 1 ATOM 1931 C C . THR A 1 235 ? 55.306 -19.001 4.709 1.00 33.18 ? 251 THR A C 1 ATOM 1932 O O . THR A 1 235 ? 55.681 -18.205 5.566 1.00 33.18 ? 251 THR A O 1 ATOM 1933 C CB . THR A 1 235 ? 57.134 -20.710 4.790 1.00 34.03 ? 251 THR A CB 1 ATOM 1934 O OG1 . THR A 1 235 ? 57.583 -20.446 3.457 1.00 34.83 ? 251 THR A OG1 1 ATOM 1935 C CG2 . THR A 1 235 ? 57.495 -22.149 5.170 1.00 33.67 ? 251 THR A CG2 1 ATOM 1936 N N . GLY A 1 236 ? 54.635 -18.629 3.621 1.00 32.64 ? 252 GLY A N 1 ATOM 1937 C CA . GLY A 1 236 ? 54.318 -17.223 3.359 1.00 32.13 ? 252 GLY A CA 1 ATOM 1938 C C . GLY A 1 236 ? 52.924 -16.831 3.828 1.00 31.62 ? 252 GLY A C 1 ATOM 1939 O O . GLY A 1 236 ? 52.121 -17.699 4.187 1.00 31.56 ? 252 GLY A O 1 ATOM 1940 N N . PRO A 1 237 ? 52.622 -15.517 3.825 1.00 31.30 ? 253 PRO A N 1 ATOM 1941 C CA . PRO A 1 237 ? 51.263 -15.051 4.143 1.00 31.01 ? 253 PRO A CA 1 ATOM 1942 C C . PRO A 1 237 ? 50.245 -15.631 3.166 1.00 30.88 ? 253 PRO A C 1 ATOM 1943 O O . PRO A 1 237 ? 50.594 -15.937 2.023 1.00 31.07 ? 253 PRO A O 1 ATOM 1944 C CB . PRO A 1 237 ? 51.357 -13.533 3.958 1.00 30.89 ? 253 PRO A CB 1 ATOM 1945 C CG . PRO A 1 237 ? 52.819 -13.215 4.113 1.00 30.93 ? 253 PRO A CG 1 ATOM 1946 C CD . PRO A 1 237 ? 53.543 -14.397 3.555 1.00 31.06 ? 253 PRO A CD 1 ATOM 1947 N N . ILE A 1 238 ? 49.000 -15.788 3.607 1.00 30.51 ? 254 ILE A N 1 ATOM 1948 C CA . ILE A 1 238 ? 47.951 -16.315 2.734 1.00 30.36 ? 254 ILE A CA 1 ATOM 1949 C C . ILE A 1 238 ? 47.536 -15.247 1.722 1.00 30.17 ? 254 ILE A C 1 ATOM 1950 O O . ILE A 1 238 ? 47.268 -14.111 2.113 1.00 30.06 ? 254 ILE A O 1 ATOM 1951 C CB . ILE A 1 238 ? 46.709 -16.791 3.533 1.00 30.53 ? 254 ILE A CB 1 ATOM 1952 C CG1 . ILE A 1 238 ? 47.110 -17.832 4.590 1.00 30.54 ? 254 ILE A CG1 1 ATOM 1953 C CG2 . ILE A 1 238 ? 45.644 -17.350 2.581 1.00 29.60 ? 254 ILE A CG2 1 ATOM 1954 C CD1 . ILE A 1 238 ? 46.001 -18.179 5.584 1.00 31.55 ? 254 ILE A CD1 1 ATOM 1955 N N . PRO A 1 239 ? 47.504 -15.600 0.415 1.00 30.25 ? 255 PRO A N 1 ATOM 1956 C CA . PRO A 1 239 ? 46.935 -14.674 -0.565 1.00 30.06 ? 255 PRO A CA 1 ATOM 1957 C C . PRO A 1 239 ? 45.475 -14.401 -0.205 1.00 30.05 ? 255 PRO A C 1 ATOM 1958 O O . PRO A 1 239 ? 44.651 -15.318 -0.177 1.00 30.09 ? 255 PRO A O 1 ATOM 1959 C CB . PRO A 1 239 ? 47.054 -15.443 -1.892 1.00 30.04 ? 255 PRO A CB 1 ATOM 1960 C CG . PRO A 1 239 ? 48.187 -16.391 -1.677 1.00 30.11 ? 255 PRO A CG 1 ATOM 1961 C CD . PRO A 1 239 ? 48.027 -16.819 -0.229 1.00 30.10 ? 255 PRO A CD 1 ATOM 1962 N N . MET A 1 240 ? 45.170 -13.143 0.089 1.00 30.42 ? 256 MET A N 1 ATOM 1963 C CA . MET A 1 240 ? 43.899 -12.778 0.733 1.00 30.31 ? 256 MET A CA 1 ATOM 1964 C C . MET A 1 240 ? 42.651 -13.017 -0.118 1.00 30.54 ? 256 MET A C 1 ATOM 1965 O O . MET A 1 240 ? 41.546 -13.136 0.418 1.00 30.17 ? 256 MET A O 1 ATOM 1966 C CB . MET A 1 240 ? 43.947 -11.322 1.204 1.00 30.39 ? 256 MET A CB 1 ATOM 1967 C CG . MET A 1 240 ? 43.873 -10.290 0.076 1.00 29.96 ? 256 MET A CG 1 ATOM 1968 S SD . MET A 1 240 ? 44.154 -8.616 0.651 1.00 31.25 ? 256 MET A SD 1 ATOM 1969 C CE . MET A 1 240 ? 42.757 -8.362 1.758 1.00 29.93 ? 256 MET A CE 1 ATOM 1970 N N . HIS A 1 241 ? 42.835 -13.100 -1.437 1.00 30.30 ? 257 HIS A N 1 ATOM 1971 C CA . HIS A 1 241 ? 41.707 -13.241 -2.361 1.00 30.24 ? 257 HIS A CA 1 ATOM 1972 C C . HIS A 1 241 ? 41.070 -14.628 -2.335 1.00 30.01 ? 257 HIS A C 1 ATOM 1973 O O . HIS A 1 241 ? 39.985 -14.834 -2.889 1.00 30.37 ? 257 HIS A O 1 ATOM 1974 C CB . HIS A 1 241 ? 42.105 -12.810 -3.786 1.00 29.98 ? 257 HIS A CB 1 ATOM 1975 C CG . HIS A 1 241 ? 43.094 -13.714 -4.461 1.00 30.69 ? 257 HIS A CG 1 ATOM 1976 N ND1 . HIS A 1 241 ? 44.283 -14.098 -3.879 1.00 29.88 ? 257 HIS A ND1 1 ATOM 1977 C CD2 . HIS A 1 241 ? 43.092 -14.260 -5.704 1.00 30.86 ? 257 HIS A CD2 1 ATOM 1978 C CE1 . HIS A 1 241 ? 44.956 -14.865 -4.721 1.00 29.97 ? 257 HIS A CE1 1 ATOM 1979 N NE2 . HIS A 1 241 ? 44.253 -14.983 -5.833 1.00 30.28 ? 257 HIS A NE2 1 ATOM 1980 N N . LEU A 1 242 ? 41.738 -15.566 -1.669 1.00 29.58 ? 258 LEU A N 1 ATOM 1981 C CA . LEU A 1 242 ? 41.255 -16.939 -1.541 1.00 29.73 ? 258 LEU A CA 1 ATOM 1982 C C . LEU A 1 242 ? 40.439 -17.161 -0.267 1.00 29.76 ? 258 LEU A C 1 ATOM 1983 O O . LEU A 1 242 ? 39.972 -18.275 -0.006 1.00 29.79 ? 258 LEU A O 1 ATOM 1984 C CB . LEU A 1 242 ? 42.439 -17.913 -1.546 1.00 29.57 ? 258 LEU A CB 1 ATOM 1985 C CG . LEU A 1 242 ? 43.506 -17.705 -2.620 1.00 30.27 ? 258 LEU A CG 1 ATOM 1986 C CD1 . LEU A 1 242 ? 44.686 -18.616 -2.339 1.00 30.34 ? 258 LEU A CD1 1 ATOM 1987 C CD2 . LEU A 1 242 ? 42.933 -17.964 -4.015 1.00 29.29 ? 258 LEU A CD2 1 ATOM 1988 N N . LEU A 1 243 ? 40.264 -16.105 0.520 1.00 29.81 ? 259 LEU A N 1 ATOM 1989 C CA . LEU A 1 243 ? 39.647 -16.242 1.844 1.00 29.82 ? 259 LEU A CA 1 ATOM 1990 C C . LEU A 1 243 ? 38.142 -15.933 1.878 1.00 30.07 ? 259 LEU A C 1 ATOM 1991 O O . LEU A 1 243 ? 37.529 -15.895 2.955 1.00 30.01 ? 259 LEU A O 1 ATOM 1992 C CB . LEU A 1 243 ? 40.434 -15.425 2.875 1.00 29.68 ? 259 LEU A CB 1 ATOM 1993 C CG . LEU A 1 243 ? 41.864 -15.937 3.102 1.00 29.32 ? 259 LEU A CG 1 ATOM 1994 C CD1 . LEU A 1 243 ? 42.685 -14.958 3.936 1.00 29.65 ? 259 LEU A CD1 1 ATOM 1995 C CD2 . LEU A 1 243 ? 41.853 -17.318 3.742 1.00 29.50 ? 259 LEU A CD2 1 ATOM 1996 N N . GLY A 1 244 ? 37.556 -15.728 0.694 1.00 30.01 ? 260 GLY A N 1 ATOM 1997 C CA . GLY A 1 244 ? 36.102 -15.618 0.546 1.00 30.05 ? 260 GLY A CA 1 ATOM 1998 C C . GLY A 1 244 ? 35.490 -14.290 0.955 1.00 30.02 ? 260 GLY A C 1 ATOM 1999 O O . GLY A 1 244 ? 34.276 -14.182 1.118 1.00 30.29 ? 260 GLY A O 1 ATOM 2000 N N . ASN A 1 245 ? 36.337 -13.282 1.126 1.00 30.00 ? 261 ASN A N 1 ATOM 2001 C CA . ASN A 1 245 ? 35.907 -11.964 1.559 1.00 30.02 ? 261 ASN A CA 1 ATOM 2002 C C . ASN A 1 245 ? 36.870 -10.940 0.991 1.00 30.03 ? 261 ASN A C 1 ATOM 2003 O O . ASN A 1 245 ? 38.091 -11.156 0.996 1.00 30.20 ? 261 ASN A O 1 ATOM 2004 C CB . ASN A 1 245 ? 35.862 -11.903 3.093 1.00 29.93 ? 261 ASN A CB 1 ATOM 2005 C CG . ASN A 1 245 ? 35.386 -10.571 3.613 1.00 29.26 ? 261 ASN A CG 1 ATOM 2006 O OD1 . ASN A 1 245 ? 36.156 -9.621 3.713 1.00 29.10 ? 261 ASN A OD1 1 ATOM 2007 N ND2 . ASN A 1 245 ? 34.114 -10.499 3.970 1.00 29.71 ? 261 ASN A ND2 1 ATOM 2008 N N . MET A 1 246 ? 36.318 -9.830 0.507 1.00 29.95 ? 262 MET A N 1 ATOM 2009 C CA . MET A 1 246 ? 37.094 -8.795 -0.186 1.00 30.12 ? 262 MET A CA 1 ATOM 2010 C C . MET A 1 246 ? 38.230 -8.217 0.665 1.00 30.21 ? 262 MET A C 1 ATOM 2011 O O . MET A 1 246 ? 39.247 -7.774 0.133 1.00 30.13 ? 262 MET A O 1 ATOM 2012 C CB . MET A 1 246 ? 36.163 -7.674 -0.667 1.00 30.10 ? 262 MET A CB 1 ATOM 2013 C CG . MET A 1 246 ? 36.847 -6.575 -1.466 1.00 30.16 ? 262 MET A CG 1 ATOM 2014 S SD . MET A 1 246 ? 37.632 -7.212 -2.962 1.00 32.22 ? 262 MET A SD 1 ATOM 2015 C CE . MET A 1 246 ? 36.227 -7.310 -4.059 1.00 31.54 ? 262 MET A CE 1 ATOM 2016 N N . TRP A 1 247 ? 38.042 -8.223 1.984 1.00 29.98 ? 263 TRP A N 1 ATOM 2017 C CA . TRP A 1 247 ? 39.019 -7.659 2.915 1.00 29.97 ? 263 TRP A CA 1 ATOM 2018 C C . TRP A 1 247 ? 39.643 -8.747 3.801 1.00 30.26 ? 263 TRP A C 1 ATOM 2019 O O . TRP A 1 247 ? 40.465 -8.449 4.671 1.00 30.48 ? 263 TRP A O 1 ATOM 2020 C CB . TRP A 1 247 ? 38.371 -6.524 3.738 1.00 29.98 ? 263 TRP A CB 1 ATOM 2021 C CG . TRP A 1 247 ? 37.587 -5.601 2.838 1.00 29.54 ? 263 TRP A CG 1 ATOM 2022 C CD1 . TRP A 1 247 ? 38.060 -4.508 2.169 1.00 29.52 ? 263 TRP A CD1 1 ATOM 2023 C CD2 . TRP A 1 247 ? 36.215 -5.744 2.452 1.00 29.41 ? 263 TRP A CD2 1 ATOM 2024 N NE1 . TRP A 1 247 ? 37.061 -3.951 1.403 1.00 29.36 ? 263 TRP A NE1 1 ATOM 2025 C CE2 . TRP A 1 247 ? 35.920 -4.692 1.555 1.00 29.66 ? 263 TRP A CE2 1 ATOM 2026 C CE3 . TRP A 1 247 ? 35.203 -6.657 2.781 1.00 28.85 ? 263 TRP A CE3 1 ATOM 2027 C CZ2 . TRP A 1 247 ? 34.651 -4.527 0.981 1.00 29.20 ? 263 TRP A CZ2 1 ATOM 2028 C CZ3 . TRP A 1 247 ? 33.941 -6.494 2.208 1.00 28.82 ? 263 TRP A CZ3 1 ATOM 2029 C CH2 . TRP A 1 247 ? 33.679 -5.432 1.323 1.00 28.83 ? 263 TRP A CH2 1 ATOM 2030 N N . ALA A 1 248 ? 39.270 -10.004 3.536 1.00 30.36 ? 264 ALA A N 1 ATOM 2031 C CA . ALA A 1 248 ? 39.701 -11.173 4.311 1.00 30.62 ? 264 ALA A CA 1 ATOM 2032 C C . ALA A 1 248 ? 39.419 -11.026 5.814 1.00 30.83 ? 264 ALA A C 1 ATOM 2033 O O . ALA A 1 248 ? 40.166 -11.541 6.643 1.00 31.21 ? 264 ALA A O 1 ATOM 2034 C CB . ALA A 1 248 ? 41.182 -11.476 4.063 1.00 30.38 ? 264 ALA A CB 1 ATOM 2035 N N . GLN A 1 249 ? 38.338 -10.331 6.155 1.00 30.88 ? 265 GLN A N 1 ATOM 2036 C CA . GLN A 1 249 ? 38.034 -10.028 7.556 1.00 31.21 ? 265 GLN A CA 1 ATOM 2037 C C . GLN A 1 249 ? 37.347 -11.188 8.271 1.00 31.51 ? 265 GLN A C 1 ATOM 2038 O O . GLN A 1 249 ? 37.445 -11.324 9.497 1.00 31.51 ? 265 GLN A O 1 ATOM 2039 C CB . GLN A 1 249 ? 37.189 -8.757 7.658 1.00 31.13 ? 265 GLN A CB 1 ATOM 2040 C CG . GLN A 1 249 ? 35.792 -8.829 7.032 1.00 30.62 ? 265 GLN A CG 1 ATOM 2041 C CD . GLN A 1 249 ? 35.117 -7.475 7.014 1.00 31.24 ? 265 GLN A CD 1 ATOM 2042 O OE1 . GLN A 1 249 ? 35.570 -6.548 6.336 1.00 32.00 ? 265 GLN A OE1 1 ATOM 2043 N NE2 . GLN A 1 249 ? 34.031 -7.348 7.765 1.00 31.35 ? 265 GLN A NE2 1 ATOM 2044 N N . GLN A 1 250 ? 36.645 -12.004 7.489 1.00 31.81 ? 266 GLN A N 1 ATOM 2045 C CA . GLN A 1 250 ? 35.953 -13.197 7.966 1.00 32.81 ? 266 GLN A CA 1 ATOM 2046 C C . GLN A 1 250 ? 36.026 -14.249 6.865 1.00 32.51 ? 266 GLN A C 1 ATOM 2047 O O . GLN A 1 250 ? 35.852 -13.928 5.682 1.00 32.38 ? 266 GLN A O 1 ATOM 2048 C CB . GLN A 1 250 ? 34.502 -12.868 8.349 1.00 33.32 ? 266 GLN A CB 1 ATOM 2049 C CG . GLN A 1 250 ? 34.408 -12.093 9.691 1.00 36.48 ? 266 GLN A CG 1 ATOM 2050 C CD . GLN A 1 250 ? 33.074 -11.390 9.911 1.00 40.53 ? 266 GLN A CD 1 ATOM 2051 O OE1 . GLN A 1 250 ? 32.087 -12.023 10.289 1.00 43.29 ? 266 GLN A OE1 1 ATOM 2052 N NE2 . GLN A 1 250 ? 33.045 -10.070 9.690 1.00 40.60 ? 266 GLN A NE2 1 ATOM 2053 N N . TRP A 1 251 ? 36.311 -15.496 7.240 1.00 32.21 ? 267 TRP A N 1 ATOM 2054 C CA . TRP A 1 251 ? 36.623 -16.524 6.234 1.00 32.06 ? 267 TRP A CA 1 ATOM 2055 C C . TRP A 1 251 ? 35.547 -17.597 6.063 1.00 32.43 ? 267 TRP A C 1 ATOM 2056 O O . TRP A 1 251 ? 35.804 -18.630 5.450 1.00 32.36 ? 267 TRP A O 1 ATOM 2057 C CB . TRP A 1 251 ? 37.972 -17.205 6.530 1.00 31.49 ? 267 TRP A CB 1 ATOM 2058 C CG . TRP A 1 251 ? 39.143 -16.279 6.730 1.00 29.95 ? 267 TRP A CG 1 ATOM 2059 C CD1 . TRP A 1 251 ? 39.235 -14.967 6.358 1.00 29.00 ? 267 TRP A CD1 1 ATOM 2060 C CD2 . TRP A 1 251 ? 40.403 -16.616 7.317 1.00 28.81 ? 267 TRP A CD2 1 ATOM 2061 N NE1 . TRP A 1 251 ? 40.461 -14.462 6.701 1.00 29.27 ? 267 TRP A NE1 1 ATOM 2062 C CE2 . TRP A 1 251 ? 41.203 -15.454 7.285 1.00 28.75 ? 267 TRP A CE2 1 ATOM 2063 C CE3 . TRP A 1 251 ? 40.935 -17.790 7.870 1.00 28.31 ? 267 TRP A CE3 1 ATOM 2064 C CZ2 . TRP A 1 251 ? 42.505 -15.422 7.797 1.00 28.74 ? 267 TRP A CZ2 1 ATOM 2065 C CZ3 . TRP A 1 251 ? 42.237 -17.757 8.381 1.00 28.22 ? 267 TRP A CZ3 1 ATOM 2066 C CH2 . TRP A 1 251 ? 43.003 -16.584 8.337 1.00 28.27 ? 267 TRP A CH2 1 ATOM 2067 N N . SER A 1 252 ? 34.350 -17.366 6.591 1.00 33.05 ? 268 SER A N 1 ATOM 2068 C CA . SER A 1 252 ? 33.340 -18.430 6.619 1.00 34.12 ? 268 SER A CA 1 ATOM 2069 C C . SER A 1 252 ? 32.858 -18.892 5.243 1.00 34.28 ? 268 SER A C 1 ATOM 2070 O O . SER A 1 252 ? 32.369 -20.009 5.111 1.00 34.44 ? 268 SER A O 1 ATOM 2071 C CB . SER A 1 252 ? 32.154 -18.065 7.506 1.00 34.13 ? 268 SER A CB 1 ATOM 2072 O OG . SER A 1 252 ? 31.796 -16.717 7.342 1.00 35.75 ? 268 SER A OG 1 ATOM 2073 N N . GLU A 1 253 ? 33.020 -18.054 4.223 1.00 34.97 ? 269 GLU A N 1 ATOM 2074 C CA . GLU A 1 253 ? 32.610 -18.434 2.866 1.00 35.68 ? 269 GLU A CA 1 ATOM 2075 C C . GLU A 1 253 ? 33.425 -19.598 2.278 1.00 35.59 ? 269 GLU A C 1 ATOM 2076 O O . GLU A 1 253 ? 32.967 -20.265 1.359 1.00 35.97 ? 269 GLU A O 1 ATOM 2077 C CB . GLU A 1 253 ? 32.611 -17.226 1.921 1.00 35.88 ? 269 GLU A CB 1 ATOM 2078 C CG . GLU A 1 253 ? 31.549 -16.176 2.253 1.00 37.84 ? 269 GLU A CG 1 ATOM 2079 C CD . GLU A 1 253 ? 30.143 -16.578 1.818 1.00 40.85 ? 269 GLU A CD 1 ATOM 2080 O OE1 . GLU A 1 253 ? 29.967 -17.649 1.198 1.00 42.40 ? 269 GLU A OE1 1 ATOM 2081 O OE2 . GLU A 1 253 ? 29.205 -15.803 2.084 1.00 43.17 ? 269 GLU A OE2 1 ATOM 2082 N N . ILE A 1 254 ? 34.623 -19.840 2.806 1.00 35.70 ? 270 ILE A N 1 ATOM 2083 C CA . ILE A 1 254 ? 35.431 -20.986 2.352 1.00 35.49 ? 270 ILE A CA 1 ATOM 2084 C C . ILE A 1 254 ? 35.381 -22.180 3.316 1.00 35.75 ? 270 ILE A C 1 ATOM 2085 O O . ILE A 1 254 ? 36.200 -23.095 3.223 1.00 35.32 ? 270 ILE A O 1 ATOM 2086 C CB . ILE A 1 254 ? 36.901 -20.597 2.015 1.00 35.31 ? 270 ILE A CB 1 ATOM 2087 C CG1 . ILE A 1 254 ? 37.629 -20.063 3.257 1.00 34.88 ? 270 ILE A CG1 1 ATOM 2088 C CG2 . ILE A 1 254 ? 36.943 -19.597 0.850 1.00 34.67 ? 270 ILE A CG2 1 ATOM 2089 C CD1 . ILE A 1 254 ? 39.146 -20.170 3.185 1.00 34.19 ? 270 ILE A CD1 1 ATOM 2090 N N . ALA A 1 255 ? 34.401 -22.176 4.221 1.00 36.19 ? 271 ALA A N 1 ATOM 2091 C CA . ALA A 1 255 ? 34.222 -23.267 5.183 1.00 36.87 ? 271 ALA A CA 1 ATOM 2092 C C . ALA A 1 255 ? 34.098 -24.642 4.524 1.00 37.48 ? 271 ALA A C 1 ATOM 2093 O O . ALA A 1 255 ? 34.569 -25.637 5.069 1.00 37.52 ? 271 ALA A O 1 ATOM 2094 C CB . ALA A 1 255 ? 33.021 -23.004 6.072 1.00 36.69 ? 271 ALA A CB 1 ATOM 2095 N N . ASP A 1 256 ? 33.466 -24.696 3.355 1.00 38.12 ? 272 ASP A N 1 ATOM 2096 C CA . ASP A 1 256 ? 33.260 -25.966 2.658 1.00 38.86 ? 272 ASP A CA 1 ATOM 2097 C C . ASP A 1 256 ? 34.564 -26.600 2.156 1.00 39.02 ? 272 ASP A C 1 ATOM 2098 O O . ASP A 1 256 ? 34.619 -27.815 1.931 1.00 39.38 ? 272 ASP A O 1 ATOM 2099 C CB . ASP A 1 256 ? 32.279 -25.788 1.499 1.00 39.04 ? 272 ASP A CB 1 ATOM 2100 C CG . ASP A 1 256 ? 32.859 -24.962 0.378 1.00 40.23 ? 272 ASP A CG 1 ATOM 2101 O OD1 . ASP A 1 256 ? 33.139 -23.771 0.605 1.00 41.60 ? 272 ASP A OD1 1 ATOM 2102 O OD2 . ASP A 1 256 ? 33.048 -25.507 -0.728 1.00 42.01 ? 272 ASP A OD2 1 ATOM 2103 N N . ILE A 1 257 ? 35.607 -25.790 1.980 1.00 38.91 ? 273 ILE A N 1 ATOM 2104 C CA . ILE A 1 257 ? 36.903 -26.314 1.541 1.00 38.97 ? 273 ILE A CA 1 ATOM 2105 C C . ILE A 1 257 ? 37.969 -26.407 2.649 1.00 38.76 ? 273 ILE A C 1 ATOM 2106 O O . ILE A 1 257 ? 39.034 -26.986 2.431 1.00 38.90 ? 273 ILE A O 1 ATOM 2107 C CB . ILE A 1 257 ? 37.456 -25.585 0.274 1.00 38.97 ? 273 ILE A CB 1 ATOM 2108 C CG1 . ILE A 1 257 ? 37.569 -24.077 0.493 1.00 39.26 ? 273 ILE A CG1 1 ATOM 2109 C CG2 . ILE A 1 257 ? 36.575 -25.889 -0.949 1.00 39.70 ? 273 ILE A CG2 1 ATOM 2110 C CD1 . ILE A 1 257 ? 38.235 -23.332 -0.661 1.00 40.21 ? 273 ILE A CD1 1 ATOM 2111 N N . VAL A 1 258 ? 37.683 -25.864 3.833 1.00 38.54 ? 274 VAL A N 1 ATOM 2112 C CA . VAL A 1 258 ? 38.650 -25.908 4.943 1.00 38.39 ? 274 VAL A CA 1 ATOM 2113 C C . VAL A 1 258 ? 38.117 -26.535 6.236 1.00 38.66 ? 274 VAL A C 1 ATOM 2114 O O . VAL A 1 258 ? 38.800 -26.510 7.265 1.00 38.67 ? 274 VAL A O 1 ATOM 2115 C CB . VAL A 1 258 ? 39.258 -24.504 5.272 1.00 38.28 ? 274 VAL A CB 1 ATOM 2116 C CG1 . VAL A 1 258 ? 39.994 -23.924 4.070 1.00 37.86 ? 274 VAL A CG1 1 ATOM 2117 C CG2 . VAL A 1 258 ? 38.190 -23.539 5.781 1.00 38.19 ? 274 VAL A CG2 1 ATOM 2118 N N . SER A 1 259 ? 36.913 -27.101 6.196 1.00 39.05 ? 275 SER A N 1 ATOM 2119 C CA . SER A 1 259 ? 36.302 -27.632 7.426 1.00 39.49 ? 275 SER A CA 1 ATOM 2120 C C . SER A 1 259 ? 36.981 -28.921 7.898 1.00 39.43 ? 275 SER A C 1 ATOM 2121 O O . SER A 1 259 ? 37.346 -29.771 7.076 1.00 39.34 ? 275 SER A O 1 ATOM 2122 C CB . SER A 1 259 ? 34.785 -27.804 7.294 1.00 39.40 ? 275 SER A CB 1 ATOM 2123 O OG . SER A 1 259 ? 34.458 -29.030 6.675 1.00 41.17 ? 275 SER A OG 1 ATOM 2124 N N . PRO A 1 260 ? 37.174 -29.051 9.226 1.00 39.35 ? 276 PRO A N 1 ATOM 2125 C CA . PRO A 1 260 ? 37.841 -30.180 9.865 1.00 39.37 ? 276 PRO A CA 1 ATOM 2126 C C . PRO A 1 260 ? 37.336 -31.544 9.401 1.00 39.52 ? 276 PRO A C 1 ATOM 2127 O O . PRO A 1 260 ? 38.144 -32.428 9.130 1.00 39.40 ? 276 PRO A O 1 ATOM 2128 C CB . PRO A 1 260 ? 37.519 -29.965 11.340 1.00 39.38 ? 276 PRO A CB 1 ATOM 2129 C CG . PRO A 1 260 ? 37.499 -28.491 11.473 1.00 39.40 ? 276 PRO A CG 1 ATOM 2130 C CD . PRO A 1 260 ? 36.845 -28.002 10.209 1.00 39.31 ? 276 PRO A CD 1 ATOM 2131 N N . PHE A 1 261 ? 36.019 -31.702 9.298 1.00 39.79 ? 277 PHE A N 1 ATOM 2132 C CA . PHE A 1 261 ? 35.419 -32.982 8.927 1.00 39.93 ? 277 PHE A CA 1 ATOM 2133 C C . PHE A 1 261 ? 34.447 -32.844 7.749 1.00 40.43 ? 277 PHE A C 1 ATOM 2134 O O . PHE A 1 261 ? 33.234 -32.715 7.952 1.00 40.20 ? 277 PHE A O 1 ATOM 2135 C CB . PHE A 1 261 ? 34.734 -33.626 10.138 1.00 39.70 ? 277 PHE A CB 1 ATOM 2136 C CG . PHE A 1 261 ? 35.653 -33.845 11.313 1.00 39.45 ? 277 PHE A CG 1 ATOM 2137 C CD1 . PHE A 1 261 ? 36.512 -34.943 11.351 1.00 39.49 ? 277 PHE A CD1 1 ATOM 2138 C CD2 . PHE A 1 261 ? 35.651 -32.962 12.385 1.00 39.04 ? 277 PHE A CD2 1 ATOM 2139 C CE1 . PHE A 1 261 ? 37.364 -35.155 12.436 1.00 39.18 ? 277 PHE A CE1 1 ATOM 2140 C CE2 . PHE A 1 261 ? 36.498 -33.161 13.477 1.00 39.40 ? 277 PHE A CE2 1 ATOM 2141 C CZ . PHE A 1 261 ? 37.360 -34.261 13.501 1.00 39.73 ? 277 PHE A CZ 1 ATOM 2142 N N . PRO A 1 262 ? 34.978 -32.888 6.509 1.00 41.06 ? 278 PRO A N 1 ATOM 2143 C CA . PRO A 1 262 ? 34.203 -32.671 5.278 1.00 41.78 ? 278 PRO A CA 1 ATOM 2144 C C . PRO A 1 262 ? 33.056 -33.655 5.054 1.00 42.52 ? 278 PRO A C 1 ATOM 2145 O O . PRO A 1 262 ? 32.138 -33.358 4.287 1.00 43.06 ? 278 PRO A O 1 ATOM 2146 C CB . PRO A 1 262 ? 35.251 -32.837 4.170 1.00 41.73 ? 278 PRO A CB 1 ATOM 2147 C CG . PRO A 1 262 ? 36.535 -32.513 4.819 1.00 41.35 ? 278 PRO A CG 1 ATOM 2148 C CD . PRO A 1 262 ? 36.411 -33.063 6.214 1.00 41.10 ? 278 PRO A CD 1 ATOM 2149 N N . GLU A 1 263 ? 33.114 -34.814 5.707 1.00 43.23 ? 279 GLU A N 1 ATOM 2150 C CA . GLU A 1 263 ? 32.080 -35.840 5.558 1.00 43.87 ? 279 GLU A CA 1 ATOM 2151 C C . GLU A 1 263 ? 30.958 -35.692 6.591 1.00 44.19 ? 279 GLU A C 1 ATOM 2152 O O . GLU A 1 263 ? 29.906 -36.322 6.469 1.00 44.52 ? 279 GLU A O 1 ATOM 2153 C CB . GLU A 1 263 ? 32.695 -37.241 5.620 1.00 43.99 ? 279 GLU A CB 1 ATOM 2154 C CG . GLU A 1 263 ? 33.696 -37.520 4.502 0.50 44.54 ? 279 GLU A CG 1 ATOM 2155 C CD . GLU A 1 263 ? 33.974 -39.001 4.294 0.50 45.30 ? 279 GLU A CD 1 ATOM 2156 O OE1 . GLU A 1 263 ? 33.715 -39.809 5.214 0.50 45.22 ? 279 GLU A OE1 1 ATOM 2157 O OE2 . GLU A 1 263 ? 34.456 -39.357 3.198 0.50 45.55 ? 279 GLU A OE2 1 ATOM 2158 N N . LYS A 1 264 ? 31.195 -34.860 7.604 1.00 44.20 ? 280 LYS A N 1 ATOM 2159 C CA . LYS A 1 264 ? 30.181 -34.530 8.599 1.00 44.06 ? 280 LYS A CA 1 ATOM 2160 C C . LYS A 1 264 ? 29.512 -33.191 8.263 1.00 43.78 ? 280 LYS A C 1 ATOM 2161 O O . LYS A 1 264 ? 30.079 -32.396 7.506 1.00 43.72 ? 280 LYS A O 1 ATOM 2162 C CB . LYS A 1 264 ? 30.791 -34.522 10.008 1.00 44.12 ? 280 LYS A CB 1 ATOM 2163 C CG . LYS A 1 264 ? 31.244 -35.900 10.497 1.00 44.90 ? 280 LYS A CG 1 ATOM 2164 C CD . LYS A 1 264 ? 30.088 -36.908 10.551 1.00 46.54 ? 280 LYS A CD 1 ATOM 2165 C CE . LYS A 1 264 ? 30.553 -38.288 11.014 1.00 46.75 ? 280 LYS A CE 1 ATOM 2166 N NZ . LYS A 1 264 ? 31.012 -38.278 12.431 1.00 46.91 ? 280 LYS A NZ 1 ATOM 2167 N N . PRO A 1 265 ? 28.302 -32.938 8.816 1.00 43.45 ? 281 PRO A N 1 ATOM 2168 C CA . PRO A 1 265 ? 27.525 -31.748 8.445 1.00 43.13 ? 281 PRO A CA 1 ATOM 2169 C C . PRO A 1 265 ? 28.209 -30.404 8.710 1.00 42.60 ? 281 PRO A C 1 ATOM 2170 O O . PRO A 1 265 ? 28.846 -30.201 9.752 1.00 42.28 ? 281 PRO A O 1 ATOM 2171 C CB . PRO A 1 265 ? 26.254 -31.868 9.301 1.00 43.20 ? 281 PRO A CB 1 ATOM 2172 C CG . PRO A 1 265 ? 26.623 -32.794 10.415 1.00 43.44 ? 281 PRO A CG 1 ATOM 2173 C CD . PRO A 1 265 ? 27.567 -33.772 9.786 1.00 43.52 ? 281 PRO A CD 1 ATOM 2174 N N . LEU A 1 266 ? 28.064 -29.507 7.743 1.00 42.08 ? 282 LEU A N 1 ATOM 2175 C CA . LEU A 1 266 ? 28.489 -28.124 7.873 1.00 41.63 ? 282 LEU A CA 1 ATOM 2176 C C . LEU A 1 266 ? 27.273 -27.236 7.630 1.00 41.09 ? 282 LEU A C 1 ATOM 2177 O O . LEU A 1 266 ? 26.655 -27.298 6.560 1.00 40.94 ? 282 LEU A O 1 ATOM 2178 C CB . LEU A 1 266 ? 29.596 -27.814 6.862 1.00 41.69 ? 282 LEU A CB 1 ATOM 2179 C CG . LEU A 1 266 ? 30.145 -26.389 6.795 1.00 42.06 ? 282 LEU A CG 1 ATOM 2180 C CD1 . LEU A 1 266 ? 30.896 -26.008 8.084 1.00 41.90 ? 282 LEU A CD1 1 ATOM 2181 C CD2 . LEU A 1 266 ? 31.047 -26.269 5.579 1.00 42.01 ? 282 LEU A CD2 1 ATOM 2182 N N . VAL A 1 267 ? 26.936 -26.417 8.624 1.00 40.43 ? 283 VAL A N 1 ATOM 2183 C CA . VAL A 1 267 ? 25.717 -25.607 8.582 1.00 39.82 ? 283 VAL A CA 1 ATOM 2184 C C . VAL A 1 267 ? 25.814 -24.480 7.557 1.00 39.72 ? 283 VAL A C 1 ATOM 2185 O O . VAL A 1 267 ? 26.710 -23.636 7.628 1.00 39.32 ? 283 VAL A O 1 ATOM 2186 C CB . VAL A 1 267 ? 25.352 -25.029 9.972 1.00 39.85 ? 283 VAL A CB 1 ATOM 2187 C CG1 . VAL A 1 267 ? 24.066 -24.216 9.891 1.00 39.27 ? 283 VAL A CG1 1 ATOM 2188 C CG2 . VAL A 1 267 ? 25.202 -26.151 10.995 1.00 39.56 ? 283 VAL A CG2 1 ATOM 2189 N N . ASP A 1 268 ? 24.879 -24.492 6.609 1.00 39.61 ? 284 ASP A N 1 ATOM 2190 C CA . ASP A 1 268 ? 24.760 -23.469 5.575 1.00 39.77 ? 284 ASP A CA 1 ATOM 2191 C C . ASP A 1 268 ? 23.305 -23.441 5.077 1.00 39.58 ? 284 ASP A C 1 ATOM 2192 O O . ASP A 1 268 ? 22.951 -24.139 4.123 1.00 39.53 ? 284 ASP A O 1 ATOM 2193 C CB . ASP A 1 268 ? 25.734 -23.778 4.434 1.00 40.26 ? 284 ASP A CB 1 ATOM 2194 C CG . ASP A 1 268 ? 25.775 -22.695 3.377 1.00 41.03 ? 284 ASP A CG 1 ATOM 2195 O OD1 . ASP A 1 268 ? 24.845 -21.865 3.298 1.00 42.61 ? 284 ASP A OD1 1 ATOM 2196 O OD2 . ASP A 1 268 ? 26.754 -22.678 2.611 1.00 44.23 ? 284 ASP A OD2 1 ATOM 2197 N N . VAL A 1 269 ? 22.470 -22.624 5.721 1.00 39.22 ? 285 VAL A N 1 ATOM 2198 C CA . VAL A 1 269 ? 21.011 -22.681 5.524 1.00 38.94 ? 285 VAL A CA 1 ATOM 2199 C C . VAL A 1 269 ? 20.451 -21.825 4.382 1.00 39.01 ? 285 VAL A C 1 ATOM 2200 O O . VAL A 1 269 ? 19.234 -21.751 4.197 1.00 38.99 ? 285 VAL A O 1 ATOM 2201 C CB . VAL A 1 269 ? 20.238 -22.391 6.843 1.00 38.90 ? 285 VAL A CB 1 ATOM 2202 C CG1 . VAL A 1 269 ? 20.679 -23.363 7.933 1.00 38.51 ? 285 VAL A CG1 1 ATOM 2203 C CG2 . VAL A 1 269 ? 20.429 -20.940 7.292 1.00 38.09 ? 285 VAL A CG2 1 ATOM 2204 N N . SER A 1 270 ? 21.337 -21.208 3.606 1.00 39.33 ? 286 SER A N 1 ATOM 2205 C CA . SER A 1 270 ? 20.930 -20.350 2.493 1.00 39.54 ? 286 SER A CA 1 ATOM 2206 C C . SER A 1 270 ? 19.984 -21.047 1.515 1.00 39.77 ? 286 SER A C 1 ATOM 2207 O O . SER A 1 270 ? 18.940 -20.497 1.159 1.00 39.80 ? 286 SER A O 1 ATOM 2208 C CB . SER A 1 270 ? 22.152 -19.814 1.751 1.00 39.54 ? 286 SER A CB 1 ATOM 2209 O OG . SER A 1 270 ? 22.953 -19.013 2.602 1.00 40.04 ? 286 SER A OG 1 ATOM 2210 N N . ALA A 1 271 ? 20.349 -22.258 1.095 1.00 40.06 ? 287 ALA A N 1 ATOM 2211 C CA . ALA A 1 271 ? 19.541 -23.037 0.148 1.00 40.09 ? 287 ALA A CA 1 ATOM 2212 C C . ALA A 1 271 ? 18.148 -23.352 0.690 1.00 40.02 ? 287 ALA A C 1 ATOM 2213 O O . ALA A 1 271 ? 17.167 -23.257 -0.041 1.00 40.13 ? 287 ALA A O 1 ATOM 2214 C CB . ALA A 1 271 ? 20.271 -24.319 -0.263 1.00 40.04 ? 287 ALA A CB 1 ATOM 2215 N N . GLU A 1 272 ? 18.071 -23.720 1.968 1.00 40.09 ? 288 GLU A N 1 ATOM 2216 C CA . GLU A 1 272 ? 16.792 -23.981 2.634 1.00 40.33 ? 288 GLU A CA 1 ATOM 2217 C C . GLU A 1 272 ? 15.920 -22.731 2.766 1.00 40.33 ? 288 GLU A C 1 ATOM 2218 O O . GLU A 1 272 ? 14.697 -22.808 2.630 1.00 39.97 ? 288 GLU A O 1 ATOM 2219 C CB . GLU A 1 272 ? 17.005 -24.606 4.018 1.00 40.54 ? 288 GLU A CB 1 ATOM 2220 C CG . GLU A 1 272 ? 17.169 -26.123 4.021 1.00 41.69 ? 288 GLU A CG 1 ATOM 2221 C CD . GLU A 1 272 ? 15.949 -26.888 3.490 1.00 42.75 ? 288 GLU A CD 1 ATOM 2222 O OE1 . GLU A 1 272 ? 14.806 -26.377 3.547 1.00 42.74 ? 288 GLU A OE1 1 ATOM 2223 O OE2 . GLU A 1 272 ? 16.147 -28.022 3.015 1.00 43.68 ? 288 GLU A OE2 1 ATOM 2224 N N . MET A 1 273 ? 16.554 -21.591 3.045 1.00 40.40 ? 289 MET A N 1 ATOM 2225 C CA . MET A 1 273 ? 15.864 -20.305 3.077 1.00 40.60 ? 289 MET A CA 1 ATOM 2226 C C . MET A 1 273 ? 15.213 -20.016 1.720 1.00 41.27 ? 289 MET A C 1 ATOM 2227 O O . MET A 1 273 ? 14.031 -19.676 1.652 1.00 41.13 ? 289 MET A O 1 ATOM 2228 C CB . MET A 1 273 ? 16.833 -19.180 3.452 1.00 40.24 ? 289 MET A CB 1 ATOM 2229 C CG . MET A 1 273 ? 17.313 -19.190 4.904 1.00 38.84 ? 289 MET A CG 1 ATOM 2230 S SD . MET A 1 273 ? 18.660 -18.017 5.176 1.00 37.44 ? 289 MET A SD 1 ATOM 2231 C CE . MET A 1 273 ? 17.802 -16.450 5.024 1.00 36.33 ? 289 MET A CE 1 ATOM 2232 N N . GLU A 1 274 ? 15.986 -20.163 0.647 1.00 42.29 ? 290 GLU A N 1 ATOM 2233 C CA . GLU A 1 274 ? 15.462 -19.973 -0.706 1.00 43.62 ? 290 GLU A CA 1 ATOM 2234 C C . GLU A 1 274 ? 14.338 -20.962 -1.025 1.00 43.84 ? 290 GLU A C 1 ATOM 2235 O O . GLU A 1 274 ? 13.286 -20.560 -1.523 1.00 43.96 ? 290 GLU A O 1 ATOM 2236 C CB . GLU A 1 274 ? 16.585 -20.029 -1.751 1.00 43.96 ? 290 GLU A CB 1 ATOM 2237 C CG . GLU A 1 274 ? 17.322 -18.697 -1.905 1.00 46.69 ? 290 GLU A CG 1 ATOM 2238 C CD . GLU A 1 274 ? 18.658 -18.814 -2.625 1.00 50.93 ? 290 GLU A CD 1 ATOM 2239 O OE1 . GLU A 1 274 ? 18.677 -19.274 -3.791 1.00 52.20 ? 290 GLU A OE1 1 ATOM 2240 O OE2 . GLU A 1 274 ? 19.695 -18.433 -2.024 1.00 52.99 ? 290 GLU A OE2 1 ATOM 2241 N N . LYS A 1 275 ? 14.550 -22.238 -0.698 1.00 44.26 ? 291 LYS A N 1 ATOM 2242 C CA . LYS A 1 275 ? 13.555 -23.290 -0.942 1.00 44.60 ? 291 LYS A CA 1 ATOM 2243 C C . LYS A 1 275 ? 12.219 -23.010 -0.246 1.00 44.29 ? 291 LYS A C 1 ATOM 2244 O O . LYS A 1 275 ? 11.155 -23.230 -0.826 1.00 44.22 ? 291 LYS A O 1 ATOM 2245 C CB . LYS A 1 275 ? 14.098 -24.661 -0.514 1.00 45.07 ? 291 LYS A CB 1 ATOM 2246 C CG . LYS A 1 275 ? 13.204 -25.845 -0.901 1.00 46.38 ? 291 LYS A CG 1 ATOM 2247 C CD . LYS A 1 275 ? 13.677 -27.151 -0.259 1.00 48.26 ? 291 LYS A CD 1 ATOM 2248 C CE . LYS A 1 275 ? 12.623 -28.248 -0.401 1.00 48.93 ? 291 LYS A CE 1 ATOM 2249 N NZ . LYS A 1 275 ? 13.143 -29.574 0.028 1.00 50.04 ? 291 LYS A NZ 1 ATOM 2250 N N . GLN A 1 276 ? 12.283 -22.514 0.989 1.00 43.73 ? 292 GLN A N 1 ATOM 2251 C CA . GLN A 1 276 ? 11.085 -22.228 1.776 1.00 43.02 ? 292 GLN A CA 1 ATOM 2252 C C . GLN A 1 276 ? 10.459 -20.857 1.473 1.00 42.65 ? 292 GLN A C 1 ATOM 2253 O O . GLN A 1 276 ? 9.490 -20.451 2.122 1.00 42.42 ? 292 GLN A O 1 ATOM 2254 C CB . GLN A 1 276 ? 11.383 -22.380 3.271 1.00 43.05 ? 292 GLN A CB 1 ATOM 2255 C CG . GLN A 1 276 ? 11.660 -23.821 3.688 1.00 43.39 ? 292 GLN A CG 1 ATOM 2256 C CD . GLN A 1 276 ? 12.075 -23.959 5.143 1.00 43.72 ? 292 GLN A CD 1 ATOM 2257 O OE1 . GLN A 1 276 ? 11.535 -23.290 6.029 1.00 44.06 ? 292 GLN A OE1 1 ATOM 2258 N NE2 . GLN A 1 276 ? 13.039 -24.840 5.396 1.00 43.65 ? 292 GLN A NE2 1 ATOM 2259 N N . GLY A 1 277 ? 11.013 -20.153 0.487 1.00 42.09 ? 293 GLY A N 1 ATOM 2260 C CA . GLY A 1 277 ? 10.459 -18.881 0.026 1.00 41.46 ? 293 GLY A CA 1 ATOM 2261 C C . GLY A 1 277 ? 10.665 -17.684 0.942 1.00 41.12 ? 293 GLY A C 1 ATOM 2262 O O . GLY A 1 277 ? 9.848 -16.761 0.950 1.00 41.09 ? 293 GLY A O 1 ATOM 2263 N N . TYR A 1 278 ? 11.756 -17.698 1.710 1.00 40.61 ? 294 TYR A N 1 ATOM 2264 C CA . TYR A 1 278 ? 12.129 -16.573 2.575 1.00 39.83 ? 294 TYR A CA 1 ATOM 2265 C C . TYR A 1 278 ? 12.297 -15.288 1.771 1.00 39.30 ? 294 TYR A C 1 ATOM 2266 O O . TYR A 1 278 ? 12.801 -15.301 0.645 1.00 38.97 ? 294 TYR A O 1 ATOM 2267 C CB . TYR A 1 278 ? 13.441 -16.867 3.305 1.00 39.91 ? 294 TYR A CB 1 ATOM 2268 C CG . TYR A 1 278 ? 13.311 -17.578 4.632 1.00 40.26 ? 294 TYR A CG 1 ATOM 2269 C CD1 . TYR A 1 278 ? 12.609 -18.778 4.745 1.00 40.65 ? 294 TYR A CD1 1 ATOM 2270 C CD2 . TYR A 1 278 ? 13.907 -17.054 5.779 1.00 41.11 ? 294 TYR A CD2 1 ATOM 2271 C CE1 . TYR A 1 278 ? 12.498 -19.435 5.966 1.00 40.60 ? 294 TYR A CE1 1 ATOM 2272 C CE2 . TYR A 1 278 ? 13.806 -17.705 7.005 1.00 41.19 ? 294 TYR A CE2 1 ATOM 2273 C CZ . TYR A 1 278 ? 13.098 -18.893 7.092 1.00 41.19 ? 294 TYR A CZ 1 ATOM 2274 O OH . TYR A 1 278 ? 12.992 -19.542 8.304 1.00 40.93 ? 294 TYR A OH 1 ATOM 2275 N N . THR A 1 279 ? 11.865 -14.183 2.371 1.00 38.55 ? 295 THR A N 1 ATOM 2276 C CA . THR A 1 279 ? 12.017 -12.851 1.801 1.00 37.86 ? 295 THR A CA 1 ATOM 2277 C C . THR A 1 279 ? 12.725 -11.960 2.835 1.00 37.38 ? 295 THR A C 1 ATOM 2278 O O . THR A 1 279 ? 12.772 -12.311 4.023 1.00 37.29 ? 295 THR A O 1 ATOM 2279 C CB . THR A 1 279 ? 10.638 -12.230 1.489 1.00 37.89 ? 295 THR A CB 1 ATOM 2280 O OG1 . THR A 1 279 ? 9.861 -12.196 2.693 1.00 37.84 ? 295 THR A OG1 1 ATOM 2281 C CG2 . THR A 1 279 ? 9.885 -13.042 0.418 1.00 37.53 ? 295 THR A CG2 1 ATOM 2282 N N . PRO A 1 280 ? 13.272 -10.809 2.395 1.00 36.90 ? 296 PRO A N 1 ATOM 2283 C CA . PRO A 1 280 ? 13.794 -9.825 3.339 1.00 36.66 ? 296 PRO A CA 1 ATOM 2284 C C . PRO A 1 280 ? 12.781 -9.462 4.427 1.00 36.61 ? 296 PRO A C 1 ATOM 2285 O O . PRO A 1 280 ? 13.146 -9.416 5.607 1.00 36.33 ? 296 PRO A O 1 ATOM 2286 C CB . PRO A 1 280 ? 14.096 -8.622 2.444 1.00 36.91 ? 296 PRO A CB 1 ATOM 2287 C CG . PRO A 1 280 ? 14.473 -9.241 1.142 1.00 36.55 ? 296 PRO A CG 1 ATOM 2288 C CD . PRO A 1 280 ? 13.546 -10.415 0.997 1.00 36.75 ? 296 PRO A CD 1 ATOM 2289 N N . LEU A 1 281 ? 11.520 -9.244 4.041 1.00 36.35 ? 297 LEU A N 1 ATOM 2290 C CA . LEU A 1 281 ? 10.454 -8.969 5.013 1.00 36.42 ? 297 LEU A CA 1 ATOM 2291 C C . LEU A 1 281 ? 10.355 -10.054 6.085 1.00 36.33 ? 297 LEU A C 1 ATOM 2292 O O . LEU A 1 281 ? 10.308 -9.749 7.281 1.00 36.16 ? 297 LEU A O 1 ATOM 2293 C CB . LEU A 1 281 ? 9.092 -8.764 4.327 1.00 36.42 ? 297 LEU A CB 1 ATOM 2294 C CG . LEU A 1 281 ? 7.916 -8.354 5.235 1.00 36.52 ? 297 LEU A CG 1 ATOM 2295 C CD1 . LEU A 1 281 ? 8.192 -7.032 5.957 1.00 35.85 ? 297 LEU A CD1 1 ATOM 2296 C CD2 . LEU A 1 281 ? 6.595 -8.273 4.455 1.00 36.14 ? 297 LEU A CD2 1 ATOM 2297 N N . LYS A 1 282 ? 10.330 -11.315 5.648 1.00 36.43 ? 298 LYS A N 1 ATOM 2298 C CA . LYS A 1 282 ? 10.272 -12.456 6.565 1.00 36.51 ? 298 LYS A CA 1 ATOM 2299 C C . LYS A 1 282 ? 11.469 -12.484 7.524 1.00 36.00 ? 298 LYS A C 1 ATOM 2300 O O . LYS A 1 282 ? 11.311 -12.718 8.721 1.00 35.78 ? 298 LYS A O 1 ATOM 2301 C CB . LYS A 1 282 ? 10.165 -13.777 5.787 1.00 36.77 ? 298 LYS A CB 1 ATOM 2302 C CG . LYS A 1 282 ? 10.131 -15.038 6.656 1.00 38.26 ? 298 LYS A CG 1 ATOM 2303 C CD . LYS A 1 282 ? 8.887 -15.078 7.541 1.00 42.09 ? 298 LYS A CD 1 ATOM 2304 C CE . LYS A 1 282 ? 8.686 -16.454 8.183 1.00 44.65 ? 298 LYS A CE 1 ATOM 2305 N NZ . LYS A 1 282 ? 7.246 -16.674 8.542 1.00 45.60 ? 298 LYS A NZ 1 ATOM 2306 N N . MET A 1 283 ? 12.657 -12.240 6.982 1.00 35.73 ? 299 MET A N 1 ATOM 2307 C CA . MET A 1 283 ? 13.891 -12.195 7.771 1.00 35.43 ? 299 MET A CA 1 ATOM 2308 C C . MET A 1 283 ? 13.825 -11.125 8.866 1.00 35.43 ? 299 MET A C 1 ATOM 2309 O O . MET A 1 283 ? 14.216 -11.379 10.009 1.00 35.30 ? 299 MET A O 1 ATOM 2310 C CB . MET A 1 283 ? 15.095 -11.963 6.853 1.00 35.23 ? 299 MET A CB 1 ATOM 2311 C CG . MET A 1 283 ? 15.369 -13.136 5.910 1.00 34.95 ? 299 MET A CG 1 ATOM 2312 S SD . MET A 1 283 ? 16.420 -12.716 4.510 1.00 34.38 ? 299 MET A SD 1 ATOM 2313 C CE . MET A 1 283 ? 18.022 -12.650 5.317 1.00 35.08 ? 299 MET A CE 1 ATOM 2314 N N . PHE A 1 284 ? 13.319 -9.941 8.519 1.00 35.15 ? 300 PHE A N 1 ATOM 2315 C CA . PHE A 1 284 ? 13.158 -8.873 9.504 1.00 35.57 ? 300 PHE A CA 1 ATOM 2316 C C . PHE A 1 284 ? 12.076 -9.180 10.533 1.00 35.68 ? 300 PHE A C 1 ATOM 2317 O O . PHE A 1 284 ? 12.244 -8.878 11.718 1.00 35.84 ? 300 PHE A O 1 ATOM 2318 C CB . PHE A 1 284 ? 12.924 -7.520 8.829 1.00 35.45 ? 300 PHE A CB 1 ATOM 2319 C CG . PHE A 1 284 ? 14.190 -6.859 8.376 1.00 35.73 ? 300 PHE A CG 1 ATOM 2320 C CD1 . PHE A 1 284 ? 14.719 -7.129 7.116 1.00 34.99 ? 300 PHE A CD1 1 ATOM 2321 C CD2 . PHE A 1 284 ? 14.875 -5.987 9.222 1.00 35.51 ? 300 PHE A CD2 1 ATOM 2322 C CE1 . PHE A 1 284 ? 15.893 -6.536 6.698 1.00 35.19 ? 300 PHE A CE1 1 ATOM 2323 C CE2 . PHE A 1 284 ? 16.054 -5.390 8.813 1.00 35.44 ? 300 PHE A CE2 1 ATOM 2324 C CZ . PHE A 1 284 ? 16.564 -5.661 7.545 1.00 35.56 ? 300 PHE A CZ 1 ATOM 2325 N N . GLN A 1 285 ? 10.987 -9.808 10.085 1.00 35.90 ? 301 GLN A N 1 ATOM 2326 C CA . GLN A 1 285 ? 9.922 -10.251 10.989 1.00 36.01 ? 301 GLN A CA 1 ATOM 2327 C C . GLN A 1 285 ? 10.439 -11.288 11.974 1.00 36.21 ? 301 GLN A C 1 ATOM 2328 O O . GLN A 1 285 ? 10.082 -11.266 13.157 1.00 36.31 ? 301 GLN A O 1 ATOM 2329 C CB . GLN A 1 285 ? 8.717 -10.798 10.210 1.00 36.07 ? 301 GLN A CB 1 ATOM 2330 C CG . GLN A 1 285 ? 7.883 -9.712 9.521 1.00 36.15 ? 301 GLN A CG 1 ATOM 2331 C CD . GLN A 1 285 ? 6.922 -10.258 8.471 1.00 36.41 ? 301 GLN A CD 1 ATOM 2332 O OE1 . GLN A 1 285 ? 7.024 -11.407 8.050 1.00 37.07 ? 301 GLN A OE1 1 ATOM 2333 N NE2 . GLN A 1 285 ? 5.987 -9.422 8.041 1.00 36.80 ? 301 GLN A NE2 1 ATOM 2334 N N . MET A 1 286 ? 11.294 -12.188 11.493 1.00 36.30 ? 302 MET A N 1 ATOM 2335 C CA . MET A 1 286 ? 11.900 -13.198 12.362 1.00 36.80 ? 302 MET A CA 1 ATOM 2336 C C . MET A 1 286 ? 12.837 -12.591 13.404 1.00 36.22 ? 302 MET A C 1 ATOM 2337 O O . MET A 1 286 ? 12.832 -13.004 14.566 1.00 36.08 ? 302 MET A O 1 ATOM 2338 C CB . MET A 1 286 ? 12.622 -14.255 11.538 1.00 37.16 ? 302 MET A CB 1 ATOM 2339 C CG . MET A 1 286 ? 11.667 -15.203 10.844 1.00 39.81 ? 302 MET A CG 1 ATOM 2340 S SD . MET A 1 286 ? 12.550 -16.341 9.783 1.00 46.32 ? 302 MET A SD 1 ATOM 2341 C CE . MET A 1 286 ? 13.143 -17.526 10.999 1.00 45.27 ? 302 MET A CE 1 ATOM 2342 N N . GLY A 1 287 ? 13.632 -11.612 12.980 1.00 36.10 ? 303 GLY A N 1 ATOM 2343 C CA . GLY A 1 287 ? 14.452 -10.835 13.904 1.00 36.16 ? 303 GLY A CA 1 ATOM 2344 C C . GLY A 1 287 ? 13.595 -10.181 14.980 1.00 36.33 ? 303 GLY A C 1 ATOM 2345 O O . GLY A 1 287 ? 13.900 -10.287 16.171 1.00 36.07 ? 303 GLY A O 1 ATOM 2346 N N . ASP A 1 288 ? 12.514 -9.523 14.554 1.00 36.43 ? 304 ASP A N 1 ATOM 2347 C CA . ASP A 1 288 ? 11.561 -8.894 15.475 1.00 36.94 ? 304 ASP A CA 1 ATOM 2348 C C . ASP A 1 288 ? 11.014 -9.909 16.479 1.00 36.89 ? 304 ASP A C 1 ATOM 2349 O O . ASP A 1 288 ? 10.979 -9.646 17.689 1.00 36.78 ? 304 ASP A O 1 ATOM 2350 C CB . ASP A 1 288 ? 10.414 -8.221 14.697 1.00 37.10 ? 304 ASP A CB 1 ATOM 2351 C CG . ASP A 1 288 ? 9.499 -7.375 15.589 1.00 37.72 ? 304 ASP A CG 1 ATOM 2352 O OD1 . ASP A 1 288 ? 9.984 -6.761 16.562 1.00 38.45 ? 304 ASP A OD1 1 ATOM 2353 O OD2 . ASP A 1 288 ? 8.287 -7.310 15.302 1.00 38.68 ? 304 ASP A OD2 1 ATOM 2354 N N . ASP A 1 289 ? 10.614 -11.071 15.966 1.00 36.98 ? 305 ASP A N 1 ATOM 2355 C CA . ASP A 1 289 ? 10.126 -12.177 16.787 1.00 37.27 ? 305 ASP A CA 1 ATOM 2356 C C . ASP A 1 289 ? 11.139 -12.589 17.861 1.00 36.64 ? 305 ASP A C 1 ATOM 2357 O O . ASP A 1 289 ? 10.760 -12.843 19.009 1.00 36.35 ? 305 ASP A O 1 ATOM 2358 C CB . ASP A 1 289 ? 9.750 -13.371 15.894 1.00 37.67 ? 305 ASP A CB 1 ATOM 2359 C CG . ASP A 1 289 ? 9.361 -14.619 16.690 1.00 39.84 ? 305 ASP A CG 1 ATOM 2360 O OD1 . ASP A 1 289 ? 8.774 -14.508 17.791 1.00 40.41 ? 305 ASP A OD1 1 ATOM 2361 O OD2 . ASP A 1 289 ? 9.630 -15.732 16.189 1.00 43.40 ? 305 ASP A OD2 1 ATOM 2362 N N . PHE A 1 290 ? 12.421 -12.644 17.490 1.00 36.13 ? 306 PHE A N 1 ATOM 2363 C CA . PHE A 1 290 ? 13.473 -13.011 18.442 1.00 35.59 ? 306 PHE A CA 1 ATOM 2364 C C . PHE A 1 290 ? 13.506 -12.043 19.622 1.00 35.26 ? 306 PHE A C 1 ATOM 2365 O O . PHE A 1 290 ? 13.510 -12.469 20.776 1.00 35.10 ? 306 PHE A O 1 ATOM 2366 C CB . PHE A 1 290 ? 14.851 -13.083 17.768 1.00 35.45 ? 306 PHE A CB 1 ATOM 2367 C CG . PHE A 1 290 ? 15.804 -14.055 18.425 1.00 35.21 ? 306 PHE A CG 1 ATOM 2368 C CD1 . PHE A 1 290 ? 16.263 -13.843 19.728 1.00 34.16 ? 306 PHE A CD1 1 ATOM 2369 C CD2 . PHE A 1 290 ? 16.236 -15.189 17.741 1.00 34.49 ? 306 PHE A CD2 1 ATOM 2370 C CE1 . PHE A 1 290 ? 17.143 -14.739 20.335 1.00 34.41 ? 306 PHE A CE1 1 ATOM 2371 C CE2 . PHE A 1 290 ? 17.120 -16.096 18.344 1.00 34.87 ? 306 PHE A CE2 1 ATOM 2372 C CZ . PHE A 1 290 ? 17.571 -15.870 19.644 1.00 34.09 ? 306 PHE A CZ 1 ATOM 2373 N N . PHE A 1 291 ? 13.525 -10.746 19.326 1.00 35.22 ? 307 PHE A N 1 ATOM 2374 C CA . PHE A 1 291 ? 13.540 -9.722 20.369 1.00 35.39 ? 307 PHE A CA 1 ATOM 2375 C C . PHE A 1 291 ? 12.290 -9.761 21.248 1.00 35.69 ? 307 PHE A C 1 ATOM 2376 O O . PHE A 1 291 ? 12.399 -9.725 22.474 1.00 35.54 ? 307 PHE A O 1 ATOM 2377 C CB . PHE A 1 291 ? 13.738 -8.322 19.778 1.00 35.22 ? 307 PHE A CB 1 ATOM 2378 C CG . PHE A 1 291 ? 15.159 -8.021 19.398 1.00 34.70 ? 307 PHE A CG 1 ATOM 2379 C CD1 . PHE A 1 291 ? 16.075 -7.602 20.356 1.00 34.35 ? 307 PHE A CD1 1 ATOM 2380 C CD2 . PHE A 1 291 ? 15.587 -8.165 18.080 1.00 34.39 ? 307 PHE A CD2 1 ATOM 2381 C CE1 . PHE A 1 291 ? 17.397 -7.329 20.007 1.00 33.97 ? 307 PHE A CE1 1 ATOM 2382 C CE2 . PHE A 1 291 ? 16.904 -7.894 17.722 1.00 33.44 ? 307 PHE A CE2 1 ATOM 2383 C CZ . PHE A 1 291 ? 17.809 -7.469 18.688 1.00 33.76 ? 307 PHE A CZ 1 ATOM 2384 N N . THR A 1 292 ? 11.111 -9.854 20.630 1.00 35.97 ? 308 THR A N 1 ATOM 2385 C CA . THR A 1 292 ? 9.865 -9.903 21.403 1.00 36.58 ? 308 THR A CA 1 ATOM 2386 C C . THR A 1 292 ? 9.771 -11.171 22.249 1.00 36.64 ? 308 THR A C 1 ATOM 2387 O O . THR A 1 292 ? 9.266 -11.123 23.366 1.00 36.95 ? 308 THR A O 1 ATOM 2388 C CB . THR A 1 292 ? 8.593 -9.711 20.540 1.00 36.54 ? 308 THR A CB 1 ATOM 2389 O OG1 . THR A 1 292 ? 8.535 -10.707 19.516 1.00 37.27 ? 308 THR A OG1 1 ATOM 2390 C CG2 . THR A 1 292 ? 8.591 -8.341 19.896 1.00 36.50 ? 308 THR A CG2 1 ATOM 2391 N N . SER A 1 293 ? 10.299 -12.285 21.733 1.00 36.82 ? 309 SER A N 1 ATOM 2392 C CA . SER A 1 293 ? 10.323 -13.561 22.461 1.00 36.85 ? 309 SER A CA 1 ATOM 2393 C C . SER A 1 293 ? 11.095 -13.465 23.769 1.00 37.33 ? 309 SER A C 1 ATOM 2394 O O . SER A 1 293 ? 10.858 -14.232 24.697 1.00 37.05 ? 309 SER A O 1 ATOM 2395 C CB . SER A 1 293 ? 10.950 -14.661 21.611 1.00 36.99 ? 309 SER A CB 1 ATOM 2396 O OG . SER A 1 293 ? 12.368 -14.631 21.711 1.00 36.69 ? 309 SER A OG 1 ATOM 2397 N N . MET A 1 294 ? 12.037 -12.530 23.819 1.00 37.62 ? 310 MET A N 1 ATOM 2398 C CA . MET A 1 294 ? 12.854 -12.313 25.002 1.00 38.14 ? 310 MET A CA 1 ATOM 2399 C C . MET A 1 294 ? 12.242 -11.261 25.919 1.00 38.20 ? 310 MET A C 1 ATOM 2400 O O . MET A 1 294 ? 12.891 -10.808 26.860 1.00 38.29 ? 310 MET A O 1 ATOM 2401 C CB . MET A 1 294 ? 14.259 -11.871 24.592 1.00 37.98 ? 310 MET A CB 1 ATOM 2402 C CG . MET A 1 294 ? 15.046 -12.915 23.823 1.00 38.87 ? 310 MET A CG 1 ATOM 2403 S SD . MET A 1 294 ? 16.642 -12.276 23.278 1.00 39.14 ? 310 MET A SD 1 ATOM 2404 C CE . MET A 1 294 ? 17.470 -12.021 24.840 1.00 38.82 ? 310 MET A CE 1 ATOM 2405 N N . ASN A 1 295 ? 10.999 -10.874 25.640 1.00 38.71 ? 311 ASN A N 1 ATOM 2406 C CA . ASN A 1 295 ? 10.310 -9.824 26.397 1.00 39.24 ? 311 ASN A CA 1 ATOM 2407 C C . ASN A 1 295 ? 10.945 -8.437 26.163 1.00 39.03 ? 311 ASN A C 1 ATOM 2408 O O . ASN A 1 295 ? 10.926 -7.566 27.040 1.00 38.95 ? 311 ASN A O 1 ATOM 2409 C CB . ASN A 1 295 ? 10.242 -10.187 27.894 1.00 39.61 ? 311 ASN A CB 1 ATOM 2410 C CG . ASN A 1 295 ? 9.211 -9.370 28.649 1.00 42.18 ? 311 ASN A CG 1 ATOM 2411 O OD1 . ASN A 1 295 ? 8.225 -8.909 28.071 1.00 42.70 ? 311 ASN A OD1 1 ATOM 2412 N ND2 . ASN A 1 295 ? 9.439 -9.186 29.953 1.00 45.93 ? 311 ASN A ND2 1 ATOM 2413 N N . LEU A 1 296 ? 11.502 -8.245 24.968 1.00 38.39 ? 312 LEU A N 1 ATOM 2414 C CA . LEU A 1 296 ? 12.050 -6.955 24.570 1.00 38.09 ? 312 LEU A CA 1 ATOM 2415 C C . LEU A 1 296 ? 11.100 -6.248 23.602 1.00 38.07 ? 312 LEU A C 1 ATOM 2416 O O . LEU A 1 296 ? 10.031 -6.774 23.271 1.00 38.21 ? 312 LEU A O 1 ATOM 2417 C CB . LEU A 1 296 ? 13.471 -7.105 23.988 1.00 38.06 ? 312 LEU A CB 1 ATOM 2418 C CG . LEU A 1 296 ? 14.581 -7.548 24.958 1.00 37.28 ? 312 LEU A CG 1 ATOM 2419 C CD1 . LEU A 1 296 ? 15.892 -7.844 24.234 1.00 36.16 ? 312 LEU A CD1 1 ATOM 2420 C CD2 . LEU A 1 296 ? 14.803 -6.529 26.081 1.00 36.36 ? 312 LEU A CD2 1 ATOM 2421 N N . THR A 1 297 ? 11.487 -5.060 23.150 1.00 37.82 ? 313 THR A N 1 ATOM 2422 C CA . THR A 1 297 ? 10.558 -4.166 22.467 1.00 37.55 ? 313 THR A CA 1 ATOM 2423 C C . THR A 1 297 ? 10.325 -4.524 21.001 1.00 37.83 ? 313 THR A C 1 ATOM 2424 O O . THR A 1 297 ? 11.265 -4.691 20.222 1.00 37.45 ? 313 THR A O 1 ATOM 2425 C CB . THR A 1 297 ? 10.995 -2.694 22.610 1.00 37.72 ? 313 THR A CB 1 ATOM 2426 O OG1 . THR A 1 297 ? 11.220 -2.406 23.995 1.00 36.96 ? 313 THR A OG1 1 ATOM 2427 C CG2 . THR A 1 297 ? 9.929 -1.741 22.059 1.00 37.57 ? 313 THR A CG2 1 ATOM 2428 N N . LYS A 1 298 ? 9.043 -4.634 20.666 1.00 37.85 ? 314 LYS A N 1 ATOM 2429 C CA . LYS A 1 298 ? 8.538 -4.830 19.315 1.00 37.91 ? 314 LYS A CA 1 ATOM 2430 C C . LYS A 1 298 ? 8.920 -3.648 18.430 1.00 37.62 ? 314 LYS A C 1 ATOM 2431 O O . LYS A 1 298 ? 8.959 -2.505 18.886 1.00 37.66 ? 314 LYS A O 1 ATOM 2432 C CB . LYS A 1 298 ? 7.009 -4.989 19.407 1.00 38.20 ? 314 LYS A CB 1 ATOM 2433 C CG . LYS A 1 298 ? 6.217 -4.962 18.106 1.00 39.67 ? 314 LYS A CG 1 ATOM 2434 C CD . LYS A 1 298 ? 4.711 -5.149 18.366 1.00 41.63 ? 314 LYS A CD 1 ATOM 2435 C CE . LYS A 1 298 ? 4.058 -3.897 18.955 1.00 42.81 ? 314 LYS A CE 1 ATOM 2436 N NZ . LYS A 1 298 ? 2.717 -4.172 19.562 1.00 43.76 ? 314 LYS A NZ 1 ATOM 2437 N N . LEU A 1 299 ? 9.216 -3.922 17.165 1.00 37.30 ? 315 LEU A N 1 ATOM 2438 C CA . LEU A 1 299 ? 9.468 -2.851 16.206 1.00 37.20 ? 315 LEU A CA 1 ATOM 2439 C C . LEU A 1 299 ? 8.203 -2.002 16.011 1.00 37.52 ? 315 LEU A C 1 ATOM 2440 O O . LEU A 1 299 ? 7.104 -2.550 15.879 1.00 37.39 ? 315 LEU A O 1 ATOM 2441 C CB . LEU A 1 299 ? 9.959 -3.415 14.866 1.00 37.03 ? 315 LEU A CB 1 ATOM 2442 C CG . LEU A 1 299 ? 11.275 -4.207 14.852 1.00 36.53 ? 315 LEU A CG 1 ATOM 2443 C CD1 . LEU A 1 299 ? 11.519 -4.823 13.478 1.00 34.77 ? 315 LEU A CD1 1 ATOM 2444 C CD2 . LEU A 1 299 ? 12.446 -3.334 15.257 1.00 35.95 ? 315 LEU A CD2 1 ATOM 2445 N N . PRO A 1 300 ? 8.353 -0.665 16.018 1.00 37.66 ? 316 PRO A N 1 ATOM 2446 C CA . PRO A 1 300 ? 7.207 0.222 15.840 1.00 37.84 ? 316 PRO A CA 1 ATOM 2447 C C . PRO A 1 300 ? 6.834 0.385 14.366 1.00 38.25 ? 316 PRO A C 1 ATOM 2448 O O . PRO A 1 300 ? 7.652 0.108 13.484 1.00 38.09 ? 316 PRO A O 1 ATOM 2449 C CB . PRO A 1 300 ? 7.707 1.551 16.408 1.00 37.78 ? 316 PRO A CB 1 ATOM 2450 C CG . PRO A 1 300 ? 9.180 1.524 16.178 1.00 37.78 ? 316 PRO A CG 1 ATOM 2451 C CD . PRO A 1 300 ? 9.606 0.083 16.253 1.00 37.64 ? 316 PRO A CD 1 ATOM 2452 N N . GLN A 1 301 ? 5.611 0.847 14.117 1.00 38.47 ? 317 GLN A N 1 ATOM 2453 C CA . GLN A 1 301 ? 5.067 0.965 12.761 1.00 38.73 ? 317 GLN A CA 1 ATOM 2454 C C . GLN A 1 301 ? 5.947 1.797 11.824 1.00 38.69 ? 317 GLN A C 1 ATOM 2455 O O . GLN A 1 301 ? 6.060 1.491 10.632 1.00 38.54 ? 317 GLN A O 1 ATOM 2456 C CB . GLN A 1 301 ? 3.633 1.525 12.813 1.00 38.99 ? 317 GLN A CB 1 ATOM 2457 C CG . GLN A 1 301 ? 2.819 1.323 11.525 1.00 40.22 ? 317 GLN A CG 1 ATOM 2458 C CD . GLN A 1 301 ? 2.754 -0.133 11.088 1.00 41.54 ? 317 GLN A CD 1 ATOM 2459 O OE1 . GLN A 1 301 ? 2.437 -1.021 11.883 1.00 42.45 ? 317 GLN A OE1 1 ATOM 2460 N NE2 . GLN A 1 301 ? 3.069 -0.384 9.820 1.00 41.98 ? 317 GLN A NE2 1 ATOM 2461 N N . ASP A 1 302 ? 6.566 2.845 12.369 1.00 38.51 ? 318 ASP A N 1 ATOM 2462 C CA . ASP A 1 302 ? 7.481 3.699 11.614 1.00 38.70 ? 318 ASP A CA 1 ATOM 2463 C C . ASP A 1 302 ? 8.628 2.918 10.972 1.00 38.23 ? 318 ASP A C 1 ATOM 2464 O O . ASP A 1 302 ? 9.035 3.225 9.846 1.00 38.21 ? 318 ASP A O 1 ATOM 2465 C CB . ASP A 1 302 ? 8.050 4.812 12.502 1.00 39.26 ? 318 ASP A CB 1 ATOM 2466 C CG . ASP A 1 302 ? 7.185 6.065 12.513 1.00 40.78 ? 318 ASP A CG 1 ATOM 2467 O OD1 . ASP A 1 302 ? 6.011 6.012 12.073 1.00 42.49 ? 318 ASP A OD1 1 ATOM 2468 O OD2 . ASP A 1 302 ? 7.688 7.114 12.972 1.00 42.22 ? 318 ASP A OD2 1 ATOM 2469 N N . PHE A 1 303 ? 9.146 1.925 11.692 1.00 37.75 ? 319 PHE A N 1 ATOM 2470 C CA . PHE A 1 303 ? 10.194 1.055 11.165 1.00 37.76 ? 319 PHE A CA 1 ATOM 2471 C C . PHE A 1 303 ? 9.737 0.385 9.864 1.00 37.79 ? 319 PHE A C 1 ATOM 2472 O O . PHE A 1 303 ? 10.415 0.489 8.835 1.00 37.66 ? 319 PHE A O 1 ATOM 2473 C CB . PHE A 1 303 ? 10.627 -0.006 12.195 1.00 37.74 ? 319 PHE A CB 1 ATOM 2474 C CG . PHE A 1 303 ? 11.707 -0.925 11.689 1.00 37.71 ? 319 PHE A CG 1 ATOM 2475 C CD1 . PHE A 1 303 ? 11.383 -2.092 11.003 1.00 37.43 ? 319 PHE A CD1 1 ATOM 2476 C CD2 . PHE A 1 303 ? 13.051 -0.604 11.868 1.00 38.23 ? 319 PHE A CD2 1 ATOM 2477 C CE1 . PHE A 1 303 ? 12.373 -2.926 10.512 1.00 37.70 ? 319 PHE A CE1 1 ATOM 2478 C CE2 . PHE A 1 303 ? 14.056 -1.437 11.381 1.00 38.04 ? 319 PHE A CE2 1 ATOM 2479 C CZ . PHE A 1 303 ? 13.715 -2.598 10.700 1.00 37.74 ? 319 PHE A CZ 1 ATOM 2480 N N . TRP A 1 304 ? 8.582 -0.279 9.914 1.00 37.70 ? 320 TRP A N 1 ATOM 2481 C CA . TRP A 1 304 ? 8.051 -0.980 8.744 1.00 37.80 ? 320 TRP A CA 1 ATOM 2482 C C . TRP A 1 304 ? 7.691 -0.029 7.600 1.00 37.98 ? 320 TRP A C 1 ATOM 2483 O O . TRP A 1 304 ? 7.964 -0.335 6.439 1.00 37.83 ? 320 TRP A O 1 ATOM 2484 C CB . TRP A 1 304 ? 6.862 -1.857 9.130 1.00 37.62 ? 320 TRP A CB 1 ATOM 2485 C CG . TRP A 1 304 ? 7.180 -2.877 10.193 1.00 37.65 ? 320 TRP A CG 1 ATOM 2486 C CD1 . TRP A 1 304 ? 6.701 -2.904 11.475 1.00 37.21 ? 320 TRP A CD1 1 ATOM 2487 C CD2 . TRP A 1 304 ? 8.039 -4.021 10.064 1.00 37.49 ? 320 TRP A CD2 1 ATOM 2488 N NE1 . TRP A 1 304 ? 7.203 -3.991 12.147 1.00 37.12 ? 320 TRP A NE1 1 ATOM 2489 C CE2 . TRP A 1 304 ? 8.029 -4.692 11.307 1.00 37.39 ? 320 TRP A CE2 1 ATOM 2490 C CE3 . TRP A 1 304 ? 8.814 -4.544 9.018 1.00 37.65 ? 320 TRP A CE3 1 ATOM 2491 C CZ2 . TRP A 1 304 ? 8.765 -5.863 11.536 1.00 37.39 ? 320 TRP A CZ2 1 ATOM 2492 C CZ3 . TRP A 1 304 ? 9.552 -5.709 9.248 1.00 37.47 ? 320 TRP A CZ3 1 ATOM 2493 C CH2 . TRP A 1 304 ? 9.519 -6.352 10.499 1.00 37.05 ? 320 TRP A CH2 1 ATOM 2494 N N . ASP A 1 305 ? 7.117 1.130 7.938 1.00 38.10 ? 321 ASP A N 1 ATOM 2495 C CA . ASP A 1 305 ? 6.716 2.137 6.943 1.00 38.26 ? 321 ASP A CA 1 ATOM 2496 C C . ASP A 1 305 ? 7.880 2.812 6.216 1.00 38.20 ? 321 ASP A C 1 ATOM 2497 O O . ASP A 1 305 ? 7.783 3.105 5.025 1.00 37.96 ? 321 ASP A O 1 ATOM 2498 C CB . ASP A 1 305 ? 5.855 3.239 7.589 1.00 38.66 ? 321 ASP A CB 1 ATOM 2499 C CG . ASP A 1 305 ? 4.500 2.736 8.085 1.00 39.26 ? 321 ASP A CG 1 ATOM 2500 O OD1 . ASP A 1 305 ? 4.143 1.570 7.838 1.00 40.24 ? 321 ASP A OD1 1 ATOM 2501 O OD2 . ASP A 1 305 ? 3.786 3.524 8.735 1.00 41.36 ? 321 ASP A OD2 1 ATOM 2502 N N . LYS A 1 306 ? 8.970 3.073 6.935 1.00 38.08 ? 322 LYS A N 1 ATOM 2503 C CA . LYS A 1 306 ? 10.033 3.940 6.416 1.00 37.96 ? 322 LYS A CA 1 ATOM 2504 C C . LYS A 1 306 ? 11.347 3.238 6.049 1.00 37.56 ? 322 LYS A C 1 ATOM 2505 O O . LYS A 1 306 ? 12.185 3.826 5.358 1.00 37.25 ? 322 LYS A O 1 ATOM 2506 C CB . LYS A 1 306 ? 10.324 5.072 7.407 1.00 38.41 ? 322 LYS A CB 1 ATOM 2507 C CG . LYS A 1 306 ? 9.151 5.998 7.700 1.00 39.24 ? 322 LYS A CG 1 ATOM 2508 C CD . LYS A 1 306 ? 9.570 7.056 8.700 1.00 40.62 ? 322 LYS A CD 1 ATOM 2509 C CE . LYS A 1 306 ? 8.543 8.170 8.817 1.00 41.77 ? 322 LYS A CE 1 ATOM 2510 N NZ . LYS A 1 306 ? 9.033 9.240 9.743 1.00 41.72 ? 322 LYS A NZ 1 ATOM 2511 N N . SER A 1 307 ? 11.537 2.005 6.515 1.00 37.21 ? 323 SER A N 1 ATOM 2512 C CA . SER A 1 307 ? 12.771 1.276 6.233 1.00 36.82 ? 323 SER A CA 1 ATOM 2513 C C . SER A 1 307 ? 12.889 0.895 4.762 1.00 37.17 ? 323 SER A C 1 ATOM 2514 O O . SER A 1 307 ? 11.890 0.773 4.051 1.00 36.41 ? 323 SER A O 1 ATOM 2515 C CB . SER A 1 307 ? 12.892 0.025 7.108 1.00 36.85 ? 323 SER A CB 1 ATOM 2516 O OG . SER A 1 307 ? 13.122 0.374 8.461 1.00 35.56 ? 323 SER A OG 1 ATOM 2517 N N . ILE A 1 308 ? 14.129 0.747 4.315 1.00 37.37 ? 324 ILE A N 1 ATOM 2518 C CA . ILE A 1 308 ? 14.421 0.191 3.011 1.00 37.79 ? 324 ILE A CA 1 ATOM 2519 C C . ILE A 1 308 ? 15.111 -1.146 3.268 1.00 38.10 ? 324 ILE A C 1 ATOM 2520 O O . ILE A 1 308 ? 16.246 -1.184 3.744 1.00 38.09 ? 324 ILE A O 1 ATOM 2521 C CB . ILE A 1 308 ? 15.316 1.131 2.177 1.00 37.75 ? 324 ILE A CB 1 ATOM 2522 C CG1 . ILE A 1 308 ? 14.609 2.469 1.943 1.00 37.81 ? 324 ILE A CG1 1 ATOM 2523 C CG2 . ILE A 1 308 ? 15.698 0.474 0.848 1.00 37.79 ? 324 ILE A CG2 1 ATOM 2524 C CD1 . ILE A 1 308 ? 15.514 3.564 1.396 1.00 37.31 ? 324 ILE A CD1 1 ATOM 2525 N N . ILE A 1 309 ? 14.411 -2.239 2.980 1.00 38.48 ? 325 ILE A N 1 ATOM 2526 C CA . ILE A 1 309 ? 14.939 -3.575 3.263 1.00 39.11 ? 325 ILE A CA 1 ATOM 2527 C C . ILE A 1 309 ? 15.299 -4.373 2.002 1.00 39.63 ? 325 ILE A C 1 ATOM 2528 O O . ILE A 1 309 ? 15.627 -5.549 2.083 1.00 39.62 ? 325 ILE A O 1 ATOM 2529 C CB . ILE A 1 309 ? 14.008 -4.392 4.201 1.00 38.90 ? 325 ILE A CB 1 ATOM 2530 C CG1 . ILE A 1 309 ? 12.636 -4.617 3.555 1.00 38.73 ? 325 ILE A CG1 1 ATOM 2531 C CG2 . ILE A 1 309 ? 13.894 -3.717 5.579 1.00 38.79 ? 325 ILE A CG2 1 ATOM 2532 C CD1 . ILE A 1 309 ? 11.729 -5.533 4.346 1.00 39.29 ? 325 ILE A CD1 1 ATOM 2533 N N . GLU A 1 310 ? 15.251 -3.723 0.845 1.00 40.68 ? 326 GLU A N 1 ATOM 2534 C CA . GLU A 1 310 ? 15.691 -4.342 -0.411 1.00 41.60 ? 326 GLU A CA 1 ATOM 2535 C C . GLU A 1 310 ? 16.424 -3.312 -1.251 1.00 41.73 ? 326 GLU A C 1 ATOM 2536 O O . GLU A 1 310 ? 16.104 -2.124 -1.192 1.00 41.39 ? 326 GLU A O 1 ATOM 2537 C CB . GLU A 1 310 ? 14.500 -4.883 -1.209 1.00 41.98 ? 326 GLU A CB 1 ATOM 2538 C CG . GLU A 1 310 ? 13.750 -6.035 -0.549 1.00 44.39 ? 326 GLU A CG 1 ATOM 2539 C CD . GLU A 1 310 ? 12.706 -6.675 -1.463 1.00 47.30 ? 326 GLU A CD 1 ATOM 2540 O OE1 . GLU A 1 310 ? 12.552 -6.222 -2.619 1.00 48.78 ? 326 GLU A OE1 1 ATOM 2541 O OE2 . GLU A 1 310 ? 12.040 -7.637 -1.021 1.00 48.20 ? 326 GLU A OE2 1 ATOM 2542 N N . LYS A 1 311 ? 17.406 -3.760 -2.030 1.00 42.19 ? 327 LYS A N 1 ATOM 2543 C CA . LYS A 1 311 ? 18.078 -2.867 -2.963 1.00 42.99 ? 327 LYS A CA 1 ATOM 2544 C C . LYS A 1 311 ? 17.051 -2.363 -3.983 1.00 43.77 ? 327 LYS A C 1 ATOM 2545 O O . LYS A 1 311 ? 16.374 -3.166 -4.625 1.00 43.64 ? 327 LYS A O 1 ATOM 2546 C CB . LYS A 1 311 ? 19.258 -3.555 -3.664 1.00 42.88 ? 327 LYS A CB 1 ATOM 2547 C CG . LYS A 1 311 ? 20.106 -2.605 -4.512 1.00 42.92 ? 327 LYS A CG 1 ATOM 2548 C CD . LYS A 1 311 ? 21.346 -3.279 -5.086 1.00 42.99 ? 327 LYS A CD 1 ATOM 2549 C CE . LYS A 1 311 ? 22.192 -2.284 -5.873 1.00 42.98 ? 327 LYS A CE 1 ATOM 2550 N NZ . LYS A 1 311 ? 23.429 -2.897 -6.451 1.00 43.13 ? 327 LYS A NZ 1 ATOM 2551 N N . PRO A 1 312 ? 16.920 -1.030 -4.113 1.00 44.67 ? 328 PRO A N 1 ATOM 2552 C CA . PRO A 1 312 ? 16.016 -0.419 -5.091 1.00 45.50 ? 328 PRO A CA 1 ATOM 2553 C C . PRO A 1 312 ? 16.319 -0.915 -6.503 1.00 46.26 ? 328 PRO A C 1 ATOM 2554 O O . PRO A 1 312 ? 17.468 -1.244 -6.800 1.00 46.36 ? 328 PRO A O 1 ATOM 2555 C CB . PRO A 1 312 ? 16.342 1.075 -4.981 1.00 45.53 ? 328 PRO A CB 1 ATOM 2556 C CG . PRO A 1 312 ? 16.895 1.238 -3.611 1.00 45.14 ? 328 PRO A CG 1 ATOM 2557 C CD . PRO A 1 312 ? 17.662 -0.012 -3.346 1.00 44.65 ? 328 PRO A CD 1 ATOM 2558 N N . THR A 1 313 ? 15.295 -0.978 -7.351 1.00 47.31 ? 329 THR A N 1 ATOM 2559 C CA . THR A 1 313 ? 15.439 -1.507 -8.713 1.00 48.31 ? 329 THR A CA 1 ATOM 2560 C C . THR A 1 313 ? 15.504 -0.433 -9.804 1.00 48.94 ? 329 THR A C 1 ATOM 2561 O O . THR A 1 313 ? 15.757 -0.749 -10.974 1.00 49.30 ? 329 THR A O 1 ATOM 2562 C CB . THR A 1 313 ? 14.321 -2.519 -9.063 1.00 48.36 ? 329 THR A CB 1 ATOM 2563 O OG1 . THR A 1 313 ? 13.061 -2.025 -8.592 1.00 49.04 ? 329 THR A OG1 1 ATOM 2564 C CG2 . THR A 1 313 ? 14.599 -3.878 -8.424 1.00 48.59 ? 329 THR A CG2 1 ATOM 2565 N N . ASP A 1 314 ? 15.285 0.828 -9.434 1.00 49.36 ? 330 ASP A N 1 ATOM 2566 C CA . ASP A 1 314 ? 15.441 1.939 -10.380 1.00 49.83 ? 330 ASP A CA 1 ATOM 2567 C C . ASP A 1 314 ? 16.929 2.144 -10.716 1.00 50.01 ? 330 ASP A C 1 ATOM 2568 O O . ASP A 1 314 ? 17.767 1.307 -10.376 1.00 50.51 ? 330 ASP A O 1 ATOM 2569 C CB . ASP A 1 314 ? 14.783 3.221 -9.841 1.00 49.85 ? 330 ASP A CB 1 ATOM 2570 C CG . ASP A 1 314 ? 15.188 3.536 -8.406 1.00 50.38 ? 330 ASP A CG 1 ATOM 2571 O OD1 . ASP A 1 314 ? 16.292 3.124 -7.996 1.00 50.68 ? 330 ASP A OD1 1 ATOM 2572 O OD2 . ASP A 1 314 ? 14.403 4.197 -7.689 1.00 50.72 ? 330 ASP A OD2 1 ATOM 2573 N N . GLY A 1 315 ? 17.269 3.240 -11.382 1.00 50.08 ? 331 GLY A N 1 ATOM 2574 C CA . GLY A 1 315 ? 18.662 3.455 -11.784 1.00 49.91 ? 331 GLY A CA 1 ATOM 2575 C C . GLY A 1 315 ? 19.598 3.941 -10.683 1.00 49.64 ? 331 GLY A C 1 ATOM 2576 O O . GLY A 1 315 ? 20.818 3.933 -10.860 1.00 49.87 ? 331 GLY A O 1 ATOM 2577 N N . ARG A 1 316 ? 19.028 4.330 -9.542 1.00 49.10 ? 332 ARG A N 1 ATOM 2578 C CA . ARG A 1 316 ? 19.714 5.191 -8.570 1.00 48.49 ? 332 ARG A CA 1 ATOM 2579 C C . ARG A 1 316 ? 20.976 4.641 -7.911 1.00 47.88 ? 332 ARG A C 1 ATOM 2580 O O . ARG A 1 316 ? 21.152 3.425 -7.774 1.00 47.91 ? 332 ARG A O 1 ATOM 2581 C CB . ARG A 1 316 ? 18.732 5.710 -7.509 1.00 48.54 ? 332 ARG A CB 1 ATOM 2582 C CG . ARG A 1 316 ? 18.529 4.838 -6.270 1.00 49.14 ? 332 ARG A CG 1 ATOM 2583 C CD . ARG A 1 316 ? 17.109 5.046 -5.784 1.00 50.36 ? 332 ARG A CD 1 ATOM 2584 N NE . ARG A 1 316 ? 16.910 4.787 -4.366 1.00 51.26 ? 332 ARG A NE 1 ATOM 2585 C CZ . ARG A 1 316 ? 15.726 4.524 -3.821 1.00 51.21 ? 332 ARG A CZ 1 ATOM 2586 N NH1 . ARG A 1 316 ? 14.640 4.461 -4.579 1.00 50.46 ? 332 ARG A NH1 1 ATOM 2587 N NH2 . ARG A 1 316 ? 15.630 4.304 -2.516 1.00 51.79 ? 332 ARG A NH2 1 ATOM 2588 N N . ASP A 1 317 ? 21.851 5.565 -7.523 1.00 46.90 ? 333 ASP A N 1 ATOM 2589 C CA . ASP A 1 317 ? 22.997 5.252 -6.688 1.00 46.13 ? 333 ASP A CA 1 ATOM 2590 C C . ASP A 1 317 ? 22.621 5.415 -5.218 1.00 45.26 ? 333 ASP A C 1 ATOM 2591 O O . ASP A 1 317 ? 21.861 6.316 -4.855 1.00 45.14 ? 333 ASP A O 1 ATOM 2592 C CB . ASP A 1 317 ? 24.182 6.151 -7.042 1.00 46.32 ? 333 ASP A CB 1 ATOM 2593 C CG . ASP A 1 317 ? 24.780 5.821 -8.399 1.00 46.83 ? 333 ASP A CG 1 ATOM 2594 O OD1 . ASP A 1 317 ? 25.229 4.671 -8.593 1.00 48.13 ? 333 ASP A OD1 1 ATOM 2595 O OD2 . ASP A 1 317 ? 24.795 6.710 -9.273 1.00 47.44 ? 333 ASP A OD2 1 ATOM 2596 N N . LEU A 1 318 ? 23.138 4.523 -4.384 1.00 44.09 ? 334 LEU A N 1 ATOM 2597 C CA . LEU A 1 318 ? 22.905 4.576 -2.944 1.00 43.10 ? 334 LEU A CA 1 ATOM 2598 C C . LEU A 1 318 ? 24.032 3.859 -2.215 1.00 42.34 ? 334 LEU A C 1 ATOM 2599 O O . LEU A 1 318 ? 24.859 3.187 -2.838 1.00 42.24 ? 334 LEU A O 1 ATOM 2600 C CB . LEU A 1 318 ? 21.548 3.951 -2.575 1.00 43.09 ? 334 LEU A CB 1 ATOM 2601 C CG . LEU A 1 318 ? 21.405 2.422 -2.594 1.00 43.44 ? 334 LEU A CG 1 ATOM 2602 C CD1 . LEU A 1 318 ? 20.305 1.971 -1.638 1.00 43.14 ? 334 LEU A CD1 1 ATOM 2603 C CD2 . LEU A 1 318 ? 21.172 1.863 -4.010 1.00 43.95 ? 334 LEU A CD2 1 ATOM 2604 N N . VAL A 1 319 ? 24.063 4.013 -0.896 1.00 41.28 ? 335 VAL A N 1 ATOM 2605 C CA . VAL A 1 319 ? 24.976 3.257 -0.054 1.00 40.36 ? 335 VAL A CA 1 ATOM 2606 C C . VAL A 1 319 ? 24.279 1.952 0.327 1.00 39.86 ? 335 VAL A C 1 ATOM 2607 O O . VAL A 1 319 ? 23.233 1.972 0.984 1.00 39.55 ? 335 VAL A O 1 ATOM 2608 C CB . VAL A 1 319 ? 25.360 4.047 1.221 1.00 40.44 ? 335 VAL A CB 1 ATOM 2609 C CG1 . VAL A 1 319 ? 26.283 3.219 2.114 1.00 40.00 ? 335 VAL A CG1 1 ATOM 2610 C CG2 . VAL A 1 319 ? 26.003 5.385 0.857 1.00 39.96 ? 335 VAL A CG2 1 ATOM 2611 N N . CYS A 1 320 ? 24.845 0.824 -0.098 1.00 39.19 ? 336 CYS A N 1 ATOM 2612 C CA . CYS A 1 320 ? 24.267 -0.480 0.231 1.00 38.95 ? 336 CYS A CA 1 ATOM 2613 C C . CYS A 1 320 ? 24.866 -1.130 1.476 1.00 38.15 ? 336 CYS A C 1 ATOM 2614 O O . CYS A 1 320 ? 24.334 -2.128 1.961 1.00 38.14 ? 336 CYS A O 1 ATOM 2615 C CB . CYS A 1 320 ? 24.319 -1.451 -0.958 1.00 39.18 ? 336 CYS A CB 1 ATOM 2616 S SG . CYS A 1 320 ? 22.779 -1.576 -1.942 1.00 40.86 ? 336 CYS A SG 1 ATOM 2617 N N . HIS A 1 321 ? 25.961 -0.583 1.997 1.00 37.26 ? 337 HIS A N 1 ATOM 2618 C CA . HIS A 1 321 ? 26.468 -1.080 3.270 1.00 36.50 ? 337 HIS A CA 1 ATOM 2619 C C . HIS A 1 321 ? 25.390 -0.811 4.318 1.00 35.85 ? 337 HIS A C 1 ATOM 2620 O O . HIS A 1 321 ? 25.005 0.339 4.538 1.00 35.90 ? 337 HIS A O 1 ATOM 2621 C CB . HIS A 1 321 ? 27.809 -0.445 3.656 1.00 36.35 ? 337 HIS A CB 1 ATOM 2622 C CG . HIS A 1 321 ? 28.467 -1.113 4.825 1.00 36.03 ? 337 HIS A CG 1 ATOM 2623 N ND1 . HIS A 1 321 ? 29.465 -2.054 4.681 1.00 35.00 ? 337 HIS A ND1 1 ATOM 2624 C CD2 . HIS A 1 321 ? 28.244 -1.001 6.158 1.00 35.29 ? 337 HIS A CD2 1 ATOM 2625 C CE1 . HIS A 1 321 ? 29.840 -2.480 5.876 1.00 35.14 ? 337 HIS A CE1 1 ATOM 2626 N NE2 . HIS A 1 321 ? 29.113 -1.858 6.788 1.00 34.19 ? 337 HIS A NE2 1 ATOM 2627 N N . ALA A 1 322 ? 24.886 -1.882 4.927 1.00 35.22 ? 338 ALA A N 1 ATOM 2628 C CA . ALA A 1 322 ? 23.708 -1.817 5.800 1.00 34.87 ? 338 ALA A CA 1 ATOM 2629 C C . ALA A 1 322 ? 23.860 -0.787 6.920 1.00 34.80 ? 338 ALA A C 1 ATOM 2630 O O . ALA A 1 322 ? 24.972 -0.497 7.347 1.00 34.66 ? 338 ALA A O 1 ATOM 2631 C CB . ALA A 1 322 ? 23.383 -3.194 6.369 1.00 34.41 ? 338 ALA A CB 1 ATOM 2632 N N . SER A 1 323 ? 22.741 -0.220 7.372 1.00 34.73 ? 339 SER A N 1 ATOM 2633 C CA . SER A 1 323 ? 22.775 0.811 8.405 1.00 34.85 ? 339 SER A CA 1 ATOM 2634 C C . SER A 1 323 ? 21.484 0.872 9.208 1.00 34.78 ? 339 SER A C 1 ATOM 2635 O O . SER A 1 323 ? 20.399 0.581 8.691 1.00 34.61 ? 339 SER A O 1 ATOM 2636 C CB . SER A 1 323 ? 23.093 2.184 7.801 1.00 34.85 ? 339 SER A CB 1 ATOM 2637 O OG . SER A 1 323 ? 22.172 2.515 6.777 1.00 35.50 ? 339 SER A OG 1 ATOM 2638 N N . ALA A 1 324 ? 21.628 1.232 10.481 1.00 34.63 ? 340 ALA A N 1 ATOM 2639 C CA . ALA A 1 324 ? 20.511 1.408 11.403 1.00 34.58 ? 340 ALA A CA 1 ATOM 2640 C C . ALA A 1 324 ? 20.497 2.859 11.889 1.00 34.78 ? 340 ALA A C 1 ATOM 2641 O O . ALA A 1 324 ? 21.536 3.401 12.283 1.00 34.93 ? 340 ALA A O 1 ATOM 2642 C CB . ALA A 1 324 ? 20.644 0.449 12.576 1.00 34.55 ? 340 ALA A CB 1 ATOM 2643 N N . TRP A 1 325 ? 19.318 3.474 11.870 1.00 34.70 ? 341 TRP A N 1 ATOM 2644 C CA . TRP A 1 325 ? 19.185 4.917 12.046 1.00 34.84 ? 341 TRP A CA 1 ATOM 2645 C C . TRP A 1 325 ? 18.250 5.284 13.201 1.00 34.88 ? 341 TRP A C 1 ATOM 2646 O O . TRP A 1 325 ? 17.135 4.757 13.305 1.00 34.64 ? 341 TRP A O 1 ATOM 2647 C CB . TRP A 1 325 ? 18.659 5.550 10.756 1.00 34.72 ? 341 TRP A CB 1 ATOM 2648 C CG . TRP A 1 325 ? 19.585 5.462 9.574 1.00 35.07 ? 341 TRP A CG 1 ATOM 2649 C CD1 . TRP A 1 325 ? 19.883 4.343 8.843 1.00 35.08 ? 341 TRP A CD1 1 ATOM 2650 C CD2 . TRP A 1 325 ? 20.300 6.541 8.960 1.00 36.12 ? 341 TRP A CD2 1 ATOM 2651 N NE1 . TRP A 1 325 ? 20.749 4.658 7.824 1.00 35.14 ? 341 TRP A NE1 1 ATOM 2652 C CE2 . TRP A 1 325 ? 21.023 5.999 7.871 1.00 35.70 ? 341 TRP A CE2 1 ATOM 2653 C CE3 . TRP A 1 325 ? 20.401 7.915 9.222 1.00 36.80 ? 341 TRP A CE3 1 ATOM 2654 C CZ2 . TRP A 1 325 ? 21.841 6.782 7.048 1.00 36.70 ? 341 TRP A CZ2 1 ATOM 2655 C CZ3 . TRP A 1 325 ? 21.213 8.697 8.399 1.00 37.13 ? 341 TRP A CZ3 1 ATOM 2656 C CH2 . TRP A 1 325 ? 21.925 8.124 7.327 1.00 37.16 ? 341 TRP A CH2 1 ATOM 2657 N N . ASP A 1 326 ? 18.720 6.179 14.065 1.00 34.76 ? 342 ASP A N 1 ATOM 2658 C CA . ASP A 1 326 ? 17.900 6.744 15.138 1.00 34.93 ? 342 ASP A CA 1 ATOM 2659 C C . ASP A 1 326 ? 17.563 8.183 14.766 1.00 35.11 ? 342 ASP A C 1 ATOM 2660 O O . ASP A 1 326 ? 18.464 8.983 14.519 1.00 35.11 ? 342 ASP A O 1 ATOM 2661 C CB . ASP A 1 326 ? 18.664 6.713 16.466 1.00 34.59 ? 342 ASP A CB 1 ATOM 2662 C CG . ASP A 1 326 ? 17.779 7.024 17.673 1.00 35.01 ? 342 ASP A CG 1 ATOM 2663 O OD1 . ASP A 1 326 ? 16.606 7.431 17.496 1.00 35.90 ? 342 ASP A OD1 1 ATOM 2664 O OD2 . ASP A 1 326 ? 18.262 6.852 18.811 1.00 32.70 ? 342 ASP A OD2 1 ATOM 2665 N N . PHE A 1 327 ? 16.276 8.515 14.720 1.00 35.41 ? 343 PHE A N 1 ATOM 2666 C CA . PHE A 1 327 ? 15.864 9.874 14.332 1.00 35.80 ? 343 PHE A CA 1 ATOM 2667 C C . PHE A 1 327 ? 15.517 10.783 15.511 1.00 36.16 ? 343 PHE A C 1 ATOM 2668 O O . PHE A 1 327 ? 15.085 11.922 15.320 1.00 36.10 ? 343 PHE A O 1 ATOM 2669 C CB . PHE A 1 327 ? 14.751 9.834 13.279 1.00 35.78 ? 343 PHE A CB 1 ATOM 2670 C CG . PHE A 1 327 ? 15.228 9.367 11.940 1.00 35.61 ? 343 PHE A CG 1 ATOM 2671 C CD1 . PHE A 1 327 ? 15.351 8.008 11.669 1.00 35.44 ? 343 PHE A CD1 1 ATOM 2672 C CD2 . PHE A 1 327 ? 15.592 10.282 10.962 1.00 35.59 ? 343 PHE A CD2 1 ATOM 2673 C CE1 . PHE A 1 327 ? 15.814 7.571 10.440 1.00 34.77 ? 343 PHE A CE1 1 ATOM 2674 C CE2 . PHE A 1 327 ? 16.052 9.854 9.722 1.00 35.65 ? 343 PHE A CE2 1 ATOM 2675 C CZ . PHE A 1 327 ? 16.167 8.493 9.462 1.00 35.41 ? 343 PHE A CZ 1 ATOM 2676 N N . TYR A 1 328 ? 15.723 10.266 16.722 1.00 36.66 ? 344 TYR A N 1 ATOM 2677 C CA . TYR A 1 328 ? 15.706 11.059 17.961 1.00 37.46 ? 344 TYR A CA 1 ATOM 2678 C C . TYR A 1 328 ? 14.370 11.711 18.323 1.00 37.60 ? 344 TYR A C 1 ATOM 2679 O O . TYR A 1 328 ? 14.338 12.713 19.042 1.00 37.75 ? 344 TYR A O 1 ATOM 2680 C CB . TYR A 1 328 ? 16.831 12.102 17.964 1.00 37.77 ? 344 TYR A CB 1 ATOM 2681 C CG . TYR A 1 328 ? 18.208 11.505 17.847 1.00 39.41 ? 344 TYR A CG 1 ATOM 2682 C CD1 . TYR A 1 328 ? 18.828 10.908 18.948 1.00 41.50 ? 344 TYR A CD1 1 ATOM 2683 C CD2 . TYR A 1 328 ? 18.893 11.532 16.638 1.00 41.30 ? 344 TYR A CD2 1 ATOM 2684 C CE1 . TYR A 1 328 ? 20.100 10.350 18.840 1.00 43.01 ? 344 TYR A CE1 1 ATOM 2685 C CE2 . TYR A 1 328 ? 20.167 10.982 16.520 1.00 43.30 ? 344 TYR A CE2 1 ATOM 2686 C CZ . TYR A 1 328 ? 20.760 10.394 17.622 1.00 44.07 ? 344 TYR A CZ 1 ATOM 2687 O OH . TYR A 1 328 ? 22.020 9.852 17.500 1.00 47.70 ? 344 TYR A OH 1 ATOM 2688 N N . LEU A 1 329 ? 13.277 11.139 17.828 1.00 37.70 ? 345 LEU A N 1 ATOM 2689 C CA . LEU A 1 329 ? 11.943 11.514 18.281 1.00 37.82 ? 345 LEU A CA 1 ATOM 2690 C C . LEU A 1 329 ? 11.442 10.377 19.171 1.00 37.88 ? 345 LEU A C 1 ATOM 2691 O O . LEU A 1 329 ? 12.151 9.962 20.096 1.00 37.81 ? 345 LEU A O 1 ATOM 2692 C CB . LEU A 1 329 ? 11.011 11.785 17.087 1.00 37.79 ? 345 LEU A CB 1 ATOM 2693 C CG . LEU A 1 329 ? 11.516 12.784 16.035 1.00 38.19 ? 345 LEU A CG 1 ATOM 2694 C CD1 . LEU A 1 329 ? 10.627 12.797 14.790 1.00 38.50 ? 345 LEU A CD1 1 ATOM 2695 C CD2 . LEU A 1 329 ? 11.668 14.194 16.615 1.00 38.76 ? 345 LEU A CD2 1 ATOM 2696 N N . THR A 1 330 ? 10.235 9.882 18.908 1.00 37.69 ? 346 THR A N 1 ATOM 2697 C CA . THR A 1 330 ? 9.735 8.675 19.562 1.00 37.95 ? 346 THR A CA 1 ATOM 2698 C C . THR A 1 330 ? 9.405 7.646 18.481 1.00 37.75 ? 346 THR A C 1 ATOM 2699 O O . THR A 1 330 ? 8.612 7.926 17.586 1.00 37.59 ? 346 THR A O 1 ATOM 2700 C CB . THR A 1 330 ? 8.460 8.946 20.402 1.00 37.97 ? 346 THR A CB 1 ATOM 2701 O OG1 . THR A 1 330 ? 8.676 10.062 21.277 1.00 39.67 ? 346 THR A OG1 1 ATOM 2702 C CG2 . THR A 1 330 ? 8.072 7.717 21.224 1.00 37.81 ? 346 THR A CG2 1 ATOM 2703 N N . ASP A 1 331 ? 10.032 6.473 18.562 1.00 37.74 ? 347 ASP A N 1 ATOM 2704 C CA . ASP A 1 331 ? 9.718 5.325 17.692 1.00 37.80 ? 347 ASP A CA 1 ATOM 2705 C C . ASP A 1 331 ? 10.021 5.520 16.205 1.00 37.72 ? 347 ASP A C 1 ATOM 2706 O O . ASP A 1 331 ? 9.622 4.695 15.382 1.00 38.06 ? 347 ASP A O 1 ATOM 2707 C CB . ASP A 1 331 ? 8.253 4.876 17.865 1.00 37.71 ? 347 ASP A CB 1 ATOM 2708 C CG . ASP A 1 331 ? 7.982 4.241 19.219 1.00 38.06 ? 347 ASP A CG 1 ATOM 2709 O OD1 . ASP A 1 331 ? 8.942 3.937 19.965 1.00 38.26 ? 347 ASP A OD1 1 ATOM 2710 O OD2 . ASP A 1 331 ? 6.793 4.037 19.534 1.00 38.26 ? 347 ASP A OD2 1 ATOM 2711 N N . ASP A 1 332 ? 10.700 6.606 15.846 1.00 37.50 ? 348 ASP A N 1 ATOM 2712 C CA . ASP A 1 332 ? 11.150 6.755 14.465 1.00 37.39 ? 348 ASP A CA 1 ATOM 2713 C C . ASP A 1 332 ? 12.571 6.221 14.360 1.00 36.98 ? 348 ASP A C 1 ATOM 2714 O O . ASP A 1 332 ? 13.543 6.931 14.606 1.00 37.04 ? 348 ASP A O 1 ATOM 2715 C CB . ASP A 1 332 ? 11.033 8.197 13.965 1.00 37.48 ? 348 ASP A CB 1 ATOM 2716 C CG . ASP A 1 332 ? 11.270 8.319 12.460 1.00 38.68 ? 348 ASP A CG 1 ATOM 2717 O OD1 . ASP A 1 332 ? 11.802 7.372 11.834 1.00 39.66 ? 348 ASP A OD1 1 ATOM 2718 O OD2 . ASP A 1 332 ? 10.930 9.379 11.900 1.00 40.25 ? 348 ASP A OD2 1 ATOM 2719 N N . VAL A 1 333 ? 12.657 4.938 14.027 1.00 36.64 ? 349 VAL A N 1 ATOM 2720 C CA . VAL A 1 333 ? 13.911 4.215 13.870 1.00 36.17 ? 349 VAL A CA 1 ATOM 2721 C C . VAL A 1 333 ? 13.812 3.409 12.571 1.00 36.02 ? 349 VAL A C 1 ATOM 2722 O O . VAL A 1 333 ? 12.738 2.905 12.238 1.00 36.19 ? 349 VAL A O 1 ATOM 2723 C CB . VAL A 1 333 ? 14.193 3.283 15.080 1.00 36.03 ? 349 VAL A CB 1 ATOM 2724 C CG1 . VAL A 1 333 ? 14.471 4.099 16.344 1.00 35.93 ? 349 VAL A CG1 1 ATOM 2725 C CG2 . VAL A 1 333 ? 13.032 2.320 15.323 1.00 36.10 ? 349 VAL A CG2 1 ATOM 2726 N N . ARG A 1 334 ? 14.914 3.302 11.835 1.00 35.35 ? 350 ARG A N 1 ATOM 2727 C CA . ARG A 1 334 ? 14.894 2.694 10.501 1.00 35.05 ? 350 ARG A CA 1 ATOM 2728 C C . ARG A 1 334 ? 16.153 1.904 10.211 1.00 34.48 ? 350 ARG A C 1 ATOM 2729 O O . ARG A 1 334 ? 17.219 2.190 10.759 1.00 34.17 ? 350 ARG A O 1 ATOM 2730 C CB . ARG A 1 334 ? 14.806 3.765 9.416 1.00 34.93 ? 350 ARG A CB 1 ATOM 2731 C CG . ARG A 1 334 ? 13.550 4.573 9.397 1.00 36.12 ? 350 ARG A CG 1 ATOM 2732 C CD . ARG A 1 334 ? 13.673 5.701 8.391 1.00 35.17 ? 350 ARG A CD 1 ATOM 2733 N NE . ARG A 1 334 ? 13.035 6.898 8.924 1.00 35.84 ? 350 ARG A NE 1 ATOM 2734 C CZ . ARG A 1 334 ? 13.010 8.080 8.321 1.00 36.39 ? 350 ARG A CZ 1 ATOM 2735 N NH1 . ARG A 1 334 ? 13.573 8.250 7.129 1.00 37.03 ? 350 ARG A NH1 1 ATOM 2736 N NH2 . ARG A 1 334 ? 12.403 9.094 8.915 1.00 37.73 ? 350 ARG A NH2 1 ATOM 2737 N N . ILE A 1 335 ? 16.019 0.933 9.312 1.00 33.69 ? 351 ILE A N 1 ATOM 2738 C CA . ILE A 1 335 ? 17.162 0.260 8.726 1.00 33.17 ? 351 ILE A CA 1 ATOM 2739 C C . ILE A 1 335 ? 17.151 0.481 7.214 1.00 33.23 ? 351 ILE A C 1 ATOM 2740 O O . ILE A 1 335 ? 16.089 0.543 6.591 1.00 32.75 ? 351 ILE A O 1 ATOM 2741 C CB . ILE A 1 335 ? 17.178 -1.250 9.091 1.00 33.27 ? 351 ILE A CB 1 ATOM 2742 C CG1 . ILE A 1 335 ? 17.756 -1.439 10.503 1.00 32.79 ? 351 ILE A CG1 1 ATOM 2743 C CG2 . ILE A 1 335 ? 17.962 -2.083 8.059 1.00 32.78 ? 351 ILE A CG2 1 ATOM 2744 C CD1 . ILE A 1 335 ? 17.530 -2.806 11.089 1.00 32.60 ? 351 ILE A CD1 1 ATOM 2745 N N . LYS A 1 336 ? 18.340 0.648 6.646 1.00 33.10 ? 352 LYS A N 1 ATOM 2746 C CA . LYS A 1 336 ? 18.528 0.545 5.207 1.00 33.17 ? 352 LYS A CA 1 ATOM 2747 C C . LYS A 1 336 ? 19.490 -0.607 4.940 1.00 33.17 ? 352 LYS A C 1 ATOM 2748 O O . LYS A 1 336 ? 20.681 -0.512 5.244 1.00 33.24 ? 352 LYS A O 1 ATOM 2749 C CB . LYS A 1 336 ? 19.065 1.851 4.617 1.00 33.00 ? 352 LYS A CB 1 ATOM 2750 C CG . LYS A 1 336 ? 19.352 1.781 3.111 1.00 32.90 ? 352 LYS A CG 1 ATOM 2751 C CD . LYS A 1 336 ? 19.524 3.162 2.471 1.00 33.81 ? 352 LYS A CD 1 ATOM 2752 C CE . LYS A 1 336 ? 20.580 4.036 3.167 1.00 33.17 ? 352 LYS A CE 1 ATOM 2753 N NZ . LYS A 1 336 ? 21.977 3.606 2.873 1.00 33.66 ? 352 LYS A NZ 1 ATOM 2754 N N . GLN A 1 337 ? 18.962 -1.698 4.393 1.00 33.31 ? 353 GLN A N 1 ATOM 2755 C CA . GLN A 1 337 ? 19.772 -2.875 4.069 1.00 33.88 ? 353 GLN A CA 1 ATOM 2756 C C . GLN A 1 337 ? 19.418 -3.416 2.687 1.00 34.16 ? 353 GLN A C 1 ATOM 2757 O O . GLN A 1 337 ? 18.243 -3.605 2.374 1.00 34.26 ? 353 GLN A O 1 ATOM 2758 C CB . GLN A 1 337 ? 19.578 -3.973 5.121 1.00 33.54 ? 353 GLN A CB 1 ATOM 2759 C CG . GLN A 1 337 ? 20.412 -5.238 4.871 1.00 33.89 ? 353 GLN A CG 1 ATOM 2760 C CD . GLN A 1 337 ? 20.447 -6.189 6.058 1.00 34.32 ? 353 GLN A CD 1 ATOM 2761 O OE1 . GLN A 1 337 ? 20.198 -5.798 7.200 1.00 34.80 ? 353 GLN A OE1 1 ATOM 2762 N NE2 . GLN A 1 337 ? 20.779 -7.446 5.792 1.00 34.54 ? 353 GLN A NE2 1 ATOM 2763 N N . CYS A 1 338 ? 20.433 -3.672 1.869 1.00 34.74 ? 354 CYS A N 1 ATOM 2764 C CA . CYS A 1 338 ? 20.220 -4.288 0.555 1.00 35.54 ? 354 CYS A CA 1 ATOM 2765 C C . CYS A 1 338 ? 20.168 -5.809 0.730 1.00 35.29 ? 354 CYS A C 1 ATOM 2766 O O . CYS A 1 338 ? 21.081 -6.537 0.337 1.00 35.37 ? 354 CYS A O 1 ATOM 2767 C CB . CYS A 1 338 ? 21.298 -3.827 -0.435 1.00 35.54 ? 354 CYS A CB 1 ATOM 2768 S SG . CYS A 1 338 ? 21.288 -2.023 -0.628 1.00 38.00 ? 354 CYS A SG 1 ATOM 2769 N N . THR A 1 339 ? 19.074 -6.269 1.330 1.00 35.50 ? 355 THR A N 1 ATOM 2770 C CA . THR A 1 339 ? 18.986 -7.616 1.898 1.00 35.41 ? 355 THR A CA 1 ATOM 2771 C C . THR A 1 339 ? 18.970 -8.724 0.849 1.00 35.95 ? 355 THR A C 1 ATOM 2772 O O . THR A 1 339 ? 18.234 -8.653 -0.137 1.00 35.92 ? 355 THR A O 1 ATOM 2773 C CB . THR A 1 339 ? 17.747 -7.767 2.803 1.00 35.25 ? 355 THR A CB 1 ATOM 2774 O OG1 . THR A 1 339 ? 17.583 -6.594 3.605 1.00 34.37 ? 355 THR A OG1 1 ATOM 2775 C CG2 . THR A 1 339 ? 17.875 -8.987 3.709 1.00 34.79 ? 355 THR A CG2 1 ATOM 2776 N N . ARG A 1 340 ? 19.796 -9.739 1.080 1.00 36.30 ? 356 ARG A N 1 ATOM 2777 C CA . ARG A 1 340 ? 19.788 -10.951 0.274 1.00 37.19 ? 356 ARG A CA 1 ATOM 2778 C C . ARG A 1 340 ? 19.369 -12.119 1.154 1.00 37.35 ? 356 ARG A C 1 ATOM 2779 O O . ARG A 1 340 ? 19.545 -12.073 2.380 1.00 37.50 ? 356 ARG A O 1 ATOM 2780 C CB . ARG A 1 340 ? 21.167 -11.201 -0.341 1.00 37.27 ? 356 ARG A CB 1 ATOM 2781 C CG . ARG A 1 340 ? 21.548 -10.185 -1.418 1.00 38.26 ? 356 ARG A CG 1 ATOM 2782 C CD . ARG A 1 340 ? 23.037 -10.232 -1.745 1.00 39.89 ? 356 ARG A CD 1 ATOM 2783 N NE . ARG A 1 340 ? 23.849 -9.711 -0.646 1.00 41.53 ? 356 ARG A NE 1 ATOM 2784 C CZ . ARG A 1 340 ? 24.554 -10.461 0.200 1.00 42.50 ? 356 ARG A CZ 1 ATOM 2785 N NH1 . ARG A 1 340 ? 24.579 -11.784 0.074 1.00 42.86 ? 356 ARG A NH1 1 ATOM 2786 N NH2 . ARG A 1 340 ? 25.245 -9.883 1.171 1.00 43.07 ? 356 ARG A NH2 1 ATOM 2787 N N . VAL A 1 341 ? 18.801 -13.152 0.536 1.00 37.32 ? 357 VAL A N 1 ATOM 2788 C CA . VAL A 1 341 ? 18.325 -14.322 1.275 1.00 37.57 ? 357 VAL A CA 1 ATOM 2789 C C . VAL A 1 341 ? 19.464 -15.331 1.475 1.00 37.79 ? 357 VAL A C 1 ATOM 2790 O O . VAL A 1 341 ? 19.594 -16.298 0.717 1.00 38.04 ? 357 VAL A O 1 ATOM 2791 C CB . VAL A 1 341 ? 17.096 -14.987 0.583 1.00 37.53 ? 357 VAL A CB 1 ATOM 2792 C CG1 . VAL A 1 341 ? 16.487 -16.063 1.473 1.00 37.33 ? 357 VAL A CG1 1 ATOM 2793 C CG2 . VAL A 1 341 ? 16.041 -13.944 0.245 1.00 37.40 ? 357 VAL A CG2 1 ATOM 2794 N N . THR A 1 342 ? 20.297 -15.084 2.487 1.00 37.58 ? 358 THR A N 1 ATOM 2795 C CA . THR A 1 342 ? 21.388 -15.996 2.840 1.00 37.43 ? 358 THR A CA 1 ATOM 2796 C C . THR A 1 342 ? 21.515 -16.118 4.357 1.00 37.67 ? 358 THR A C 1 ATOM 2797 O O . THR A 1 342 ? 20.982 -15.287 5.097 1.00 37.41 ? 358 THR A O 1 ATOM 2798 C CB . THR A 1 342 ? 22.770 -15.532 2.291 1.00 37.44 ? 358 THR A CB 1 ATOM 2799 O OG1 . THR A 1 342 ? 23.204 -14.365 3.000 1.00 36.80 ? 358 THR A OG1 1 ATOM 2800 C CG2 . THR A 1 342 ? 22.737 -15.256 0.779 1.00 36.99 ? 358 THR A CG2 1 ATOM 2801 N N . GLN A 1 343 ? 22.229 -17.149 4.806 1.00 37.80 ? 359 GLN A N 1 ATOM 2802 C CA . GLN A 1 343 ? 22.501 -17.364 6.226 1.00 38.30 ? 359 GLN A CA 1 ATOM 2803 C C . GLN A 1 343 ? 23.235 -16.160 6.821 1.00 38.37 ? 359 GLN A C 1 ATOM 2804 O O . GLN A 1 343 ? 22.846 -15.630 7.868 1.00 37.93 ? 359 GLN A O 1 ATOM 2805 C CB . GLN A 1 343 ? 23.330 -18.641 6.420 1.00 38.48 ? 359 GLN A CB 1 ATOM 2806 C CG . GLN A 1 343 ? 23.876 -18.817 7.837 1.00 39.26 ? 359 GLN A CG 1 ATOM 2807 C CD . GLN A 1 343 ? 24.334 -20.233 8.125 1.00 40.81 ? 359 GLN A CD 1 ATOM 2808 O OE1 . GLN A 1 343 ? 23.793 -21.195 7.581 1.00 40.97 ? 359 GLN A OE1 1 ATOM 2809 N NE2 . GLN A 1 343 ? 25.321 -20.370 9.004 1.00 41.19 ? 359 GLN A NE2 1 ATOM 2810 N N . ASP A 1 344 ? 24.289 -15.737 6.127 1.00 38.29 ? 360 ASP A N 1 ATOM 2811 C CA . ASP A 1 344 ? 25.100 -14.594 6.525 1.00 38.74 ? 360 ASP A CA 1 ATOM 2812 C C . ASP A 1 344 ? 24.251 -13.326 6.681 1.00 38.04 ? 360 ASP A C 1 ATOM 2813 O O . ASP A 1 344 ? 24.407 -12.583 7.652 1.00 37.72 ? 360 ASP A O 1 ATOM 2814 C CB . ASP A 1 344 ? 26.233 -14.387 5.509 1.00 39.30 ? 360 ASP A CB 1 ATOM 2815 C CG . ASP A 1 344 ? 26.960 -13.081 5.705 1.00 41.73 ? 360 ASP A CG 1 ATOM 2816 O OD1 . ASP A 1 344 ? 27.555 -12.879 6.788 1.00 44.23 ? 360 ASP A OD1 1 ATOM 2817 O OD2 . ASP A 1 344 ? 26.929 -12.250 4.768 1.00 45.26 ? 360 ASP A OD2 1 ATOM 2818 N N . GLN A 1 345 ? 23.340 -13.105 5.735 1.00 37.37 ? 361 GLN A N 1 ATOM 2819 C CA . GLN A 1 345 ? 22.436 -11.958 5.781 1.00 36.73 ? 361 GLN A CA 1 ATOM 2820 C C . GLN A 1 345 ? 21.422 -12.040 6.926 1.00 36.53 ? 361 GLN A C 1 ATOM 2821 O O . GLN A 1 345 ? 21.028 -11.012 7.481 1.00 36.45 ? 361 GLN A O 1 ATOM 2822 C CB . GLN A 1 345 ? 21.718 -11.790 4.449 1.00 36.71 ? 361 GLN A CB 1 ATOM 2823 C CG . GLN A 1 345 ? 22.551 -11.083 3.392 1.00 36.56 ? 361 GLN A CG 1 ATOM 2824 C CD . GLN A 1 345 ? 22.579 -9.585 3.604 1.00 37.19 ? 361 GLN A CD 1 ATOM 2825 O OE1 . GLN A 1 345 ? 21.627 -8.887 3.263 1.00 36.06 ? 361 GLN A OE1 1 ATOM 2826 N NE2 . GLN A 1 345 ? 23.670 -9.082 4.186 1.00 37.07 ? 361 GLN A NE2 1 ATOM 2827 N N . LEU A 1 346 ? 21.003 -13.256 7.264 1.00 35.95 ? 362 LEU A N 1 ATOM 2828 C CA . LEU A 1 346 ? 20.144 -13.476 8.416 1.00 36.11 ? 362 LEU A CA 1 ATOM 2829 C C . LEU A 1 346 ? 20.831 -12.975 9.690 1.00 35.96 ? 362 LEU A C 1 ATOM 2830 O O . LEU A 1 346 ? 20.172 -12.396 10.561 1.00 36.01 ? 362 LEU A O 1 ATOM 2831 C CB . LEU A 1 346 ? 19.755 -14.956 8.536 1.00 36.01 ? 362 LEU A CB 1 ATOM 2832 C CG . LEU A 1 346 ? 18.712 -15.378 9.575 1.00 36.47 ? 362 LEU A CG 1 ATOM 2833 C CD1 . LEU A 1 346 ? 17.354 -14.733 9.297 1.00 36.92 ? 362 LEU A CD1 1 ATOM 2834 C CD2 . LEU A 1 346 ? 18.594 -16.904 9.623 1.00 36.67 ? 362 LEU A CD2 1 ATOM 2835 N N . PHE A 1 347 ? 22.150 -13.176 9.778 1.00 35.75 ? 363 PHE A N 1 ATOM 2836 C CA . PHE A 1 347 ? 22.941 -12.664 10.907 1.00 35.79 ? 363 PHE A CA 1 ATOM 2837 C C . PHE A 1 347 ? 23.031 -11.144 10.887 1.00 35.25 ? 363 PHE A C 1 ATOM 2838 O O . PHE A 1 347 ? 22.859 -10.502 11.920 1.00 35.07 ? 363 PHE A O 1 ATOM 2839 C CB . PHE A 1 347 ? 24.355 -13.268 10.958 1.00 35.87 ? 363 PHE A CB 1 ATOM 2840 C CG . PHE A 1 347 ? 24.384 -14.774 11.050 1.00 36.66 ? 363 PHE A CG 1 ATOM 2841 C CD1 . PHE A 1 347 ? 23.338 -15.482 11.637 1.00 37.39 ? 363 PHE A CD1 1 ATOM 2842 C CD2 . PHE A 1 347 ? 25.483 -15.482 10.568 1.00 37.40 ? 363 PHE A CD2 1 ATOM 2843 C CE1 . PHE A 1 347 ? 23.373 -16.871 11.718 1.00 37.92 ? 363 PHE A CE1 1 ATOM 2844 C CE2 . PHE A 1 347 ? 25.531 -16.872 10.650 1.00 37.85 ? 363 PHE A CE2 1 ATOM 2845 C CZ . PHE A 1 347 ? 24.471 -17.568 11.225 1.00 37.98 ? 363 PHE A CZ 1 ATOM 2846 N N . THR A 1 348 ? 23.297 -10.577 9.712 1.00 34.77 ? 364 THR A N 1 ATOM 2847 C CA . THR A 1 348 ? 23.339 -9.126 9.540 1.00 34.50 ? 364 THR A CA 1 ATOM 2848 C C . THR A 1 348 ? 22.016 -8.458 9.965 1.00 34.52 ? 364 THR A C 1 ATOM 2849 O O . THR A 1 348 ? 22.030 -7.401 10.598 1.00 34.29 ? 364 THR A O 1 ATOM 2850 C CB . THR A 1 348 ? 23.715 -8.744 8.091 1.00 34.55 ? 364 THR A CB 1 ATOM 2851 O OG1 . THR A 1 348 ? 24.939 -9.401 7.733 1.00 34.56 ? 364 THR A OG1 1 ATOM 2852 C CG2 . THR A 1 348 ? 23.899 -7.240 7.948 1.00 34.12 ? 364 THR A CG2 1 ATOM 2853 N N . VAL A 1 349 ? 20.887 -9.086 9.633 1.00 34.25 ? 365 VAL A N 1 ATOM 2854 C CA . VAL A 1 349 ? 19.581 -8.562 10.016 1.00 34.22 ? 365 VAL A CA 1 ATOM 2855 C C . VAL A 1 349 ? 19.478 -8.446 11.538 1.00 34.43 ? 365 VAL A C 1 ATOM 2856 O O . VAL A 1 349 ? 19.127 -7.385 12.051 1.00 34.35 ? 365 VAL A O 1 ATOM 2857 C CB . VAL A 1 349 ? 18.422 -9.409 9.444 1.00 34.33 ? 365 VAL A CB 1 ATOM 2858 C CG1 . VAL A 1 349 ? 17.103 -9.072 10.141 1.00 34.13 ? 365 VAL A CG1 1 ATOM 2859 C CG2 . VAL A 1 349 ? 18.302 -9.191 7.933 1.00 33.73 ? 365 VAL A CG2 1 ATOM 2860 N N . HIS A 1 350 ? 19.810 -9.525 12.247 1.00 34.39 ? 366 HIS A N 1 ATOM 2861 C CA . HIS A 1 350 ? 19.768 -9.531 13.709 1.00 34.57 ? 366 HIS A CA 1 ATOM 2862 C C . HIS A 1 350 ? 20.781 -8.558 14.294 1.00 34.71 ? 366 HIS A C 1 ATOM 2863 O O . HIS A 1 350 ? 20.516 -7.918 15.311 1.00 34.83 ? 366 HIS A O 1 ATOM 2864 C CB . HIS A 1 350 ? 20.008 -10.935 14.257 1.00 34.47 ? 366 HIS A CB 1 ATOM 2865 C CG . HIS A 1 350 ? 18.846 -11.860 14.074 1.00 34.84 ? 366 HIS A CG 1 ATOM 2866 N ND1 . HIS A 1 350 ? 18.545 -12.446 12.863 1.00 34.97 ? 366 HIS A ND1 1 ATOM 2867 C CD2 . HIS A 1 350 ? 17.915 -12.306 14.951 1.00 33.80 ? 366 HIS A CD2 1 ATOM 2868 C CE1 . HIS A 1 350 ? 17.476 -13.211 13.001 1.00 34.76 ? 366 HIS A CE1 1 ATOM 2869 N NE2 . HIS A 1 350 ? 17.076 -13.144 14.259 1.00 34.48 ? 366 HIS A NE2 1 ATOM 2870 N N . HIS A 1 351 ? 21.933 -8.441 13.633 1.00 34.43 ? 367 HIS A N 1 ATOM 2871 C CA . HIS A 1 351 ? 22.977 -7.518 14.061 1.00 34.35 ? 367 HIS A CA 1 ATOM 2872 C C . HIS A 1 351 ? 22.463 -6.075 14.033 1.00 34.21 ? 367 HIS A C 1 ATOM 2873 O O . HIS A 1 351 ? 22.607 -5.323 15.008 1.00 34.04 ? 367 HIS A O 1 ATOM 2874 C CB . HIS A 1 351 ? 24.213 -7.671 13.171 1.00 34.33 ? 367 HIS A CB 1 ATOM 2875 C CG . HIS A 1 351 ? 25.261 -6.634 13.414 1.00 34.60 ? 367 HIS A CG 1 ATOM 2876 N ND1 . HIS A 1 351 ? 26.255 -6.788 14.358 1.00 35.50 ? 367 HIS A ND1 1 ATOM 2877 C CD2 . HIS A 1 351 ? 25.463 -5.422 12.848 1.00 34.56 ? 367 HIS A CD2 1 ATOM 2878 C CE1 . HIS A 1 351 ? 27.027 -5.717 14.356 1.00 35.79 ? 367 HIS A CE1 1 ATOM 2879 N NE2 . HIS A 1 351 ? 26.568 -4.873 13.451 1.00 35.26 ? 367 HIS A NE2 1 ATOM 2880 N N . GLU A 1 352 ? 21.853 -5.703 12.912 1.00 33.63 ? 368 GLU A N 1 ATOM 2881 C CA . GLU A 1 352 ? 21.329 -4.360 12.732 1.00 33.57 ? 368 GLU A CA 1 ATOM 2882 C C . GLU A 1 352 ? 20.096 -4.075 13.597 1.00 33.31 ? 368 GLU A C 1 ATOM 2883 O O . GLU A 1 352 ? 19.898 -2.937 14.042 1.00 33.34 ? 368 GLU A O 1 ATOM 2884 C CB . GLU A 1 352 ? 21.056 -4.096 11.250 1.00 33.87 ? 368 GLU A CB 1 ATOM 2885 C CG . GLU A 1 352 ? 22.336 -3.979 10.426 1.00 34.68 ? 368 GLU A CG 1 ATOM 2886 C CD . GLU A 1 352 ? 23.180 -2.797 10.852 1.00 35.65 ? 368 GLU A CD 1 ATOM 2887 O OE1 . GLU A 1 352 ? 22.679 -1.654 10.794 1.00 35.85 ? 368 GLU A OE1 1 ATOM 2888 O OE2 . GLU A 1 352 ? 24.342 -3.007 11.254 1.00 37.25 ? 368 GLU A OE2 1 ATOM 2889 N N . LEU A 1 353 ? 19.286 -5.106 13.848 1.00 32.72 ? 369 LEU A N 1 ATOM 2890 C CA . LEU A 1 353 ? 18.114 -4.970 14.717 1.00 32.34 ? 369 LEU A CA 1 ATOM 2891 C C . LEU A 1 353 ? 18.516 -4.823 16.187 1.00 32.15 ? 369 LEU A C 1 ATOM 2892 O O . LEU A 1 353 ? 17.727 -4.344 17.007 1.00 32.01 ? 369 LEU A O 1 ATOM 2893 C CB . LEU A 1 353 ? 17.130 -6.135 14.529 1.00 32.28 ? 369 LEU A CB 1 ATOM 2894 C CG . LEU A 1 353 ? 16.281 -6.165 13.245 1.00 32.08 ? 369 LEU A CG 1 ATOM 2895 C CD1 . LEU A 1 353 ? 15.522 -7.477 13.150 1.00 31.92 ? 369 LEU A CD1 1 ATOM 2896 C CD2 . LEU A 1 353 ? 15.304 -4.989 13.161 1.00 31.35 ? 369 LEU A CD2 1 ATOM 2897 N N . GLY A 1 354 ? 19.744 -5.228 16.510 1.00 31.66 ? 370 GLY A N 1 ATOM 2898 C CA . GLY A 1 354 ? 20.321 -4.975 17.837 1.00 31.42 ? 370 GLY A CA 1 ATOM 2899 C C . GLY A 1 354 ? 20.497 -3.484 18.091 1.00 31.36 ? 370 GLY A C 1 ATOM 2900 O O . GLY A 1 354 ? 20.282 -3.007 19.209 1.00 31.25 ? 370 GLY A O 1 ATOM 2901 N N . HIS A 1 355 ? 20.876 -2.745 17.047 1.00 30.93 ? 371 HIS A N 1 ATOM 2902 C CA . HIS A 1 355 ? 20.992 -1.293 17.147 1.00 31.08 ? 371 HIS A CA 1 ATOM 2903 C C . HIS A 1 355 ? 19.633 -0.649 17.379 1.00 30.99 ? 371 HIS A C 1 ATOM 2904 O O . HIS A 1 355 ? 19.499 0.226 18.231 1.00 30.63 ? 371 HIS A O 1 ATOM 2905 C CB . HIS A 1 355 ? 21.623 -0.698 15.892 1.00 31.02 ? 371 HIS A CB 1 ATOM 2906 C CG . HIS A 1 355 ? 23.026 -1.146 15.647 1.00 31.35 ? 371 HIS A CG 1 ATOM 2907 N ND1 . HIS A 1 355 ? 24.033 -0.985 16.576 1.00 31.16 ? 371 HIS A ND1 1 ATOM 2908 C CD2 . HIS A 1 355 ? 23.600 -1.722 14.565 1.00 30.90 ? 371 HIS A CD2 1 ATOM 2909 C CE1 . HIS A 1 355 ? 25.161 -1.461 16.084 1.00 31.22 ? 371 HIS A CE1 1 ATOM 2910 N NE2 . HIS A 1 355 ? 24.926 -1.909 14.864 1.00 31.88 ? 371 HIS A NE2 1 ATOM 2911 N N . ILE A 1 356 ? 18.638 -1.085 16.603 1.00 30.98 ? 372 ILE A N 1 ATOM 2912 C CA . ILE A 1 356 ? 17.272 -0.583 16.716 1.00 30.70 ? 372 ILE A CA 1 ATOM 2913 C C . ILE A 1 356 ? 16.723 -0.798 18.130 1.00 30.84 ? 372 ILE A C 1 ATOM 2914 O O . ILE A 1 356 ? 16.125 0.101 18.712 1.00 31.10 ? 372 ILE A O 1 ATOM 2915 C CB . ILE A 1 356 ? 16.320 -1.246 15.681 1.00 30.75 ? 372 ILE A CB 1 ATOM 2916 C CG1 . ILE A 1 356 ? 16.802 -1.016 14.234 1.00 30.05 ? 372 ILE A CG1 1 ATOM 2917 C CG2 . ILE A 1 356 ? 14.883 -0.763 15.886 1.00 30.24 ? 372 ILE A CG2 1 ATOM 2918 C CD1 . ILE A 1 356 ? 16.872 0.444 13.785 1.00 30.09 ? 372 ILE A CD1 1 ATOM 2919 N N . GLN A 1 357 ? 16.920 -1.995 18.666 1.00 30.86 ? 373 GLN A N 1 ATOM 2920 C CA . GLN A 1 357 ? 16.508 -2.297 20.021 1.00 31.26 ? 373 GLN A CA 1 ATOM 2921 C C . GLN A 1 357 ? 17.166 -1.339 21.019 1.00 31.49 ? 373 GLN A C 1 ATOM 2922 O O . GLN A 1 357 ? 16.506 -0.850 21.950 1.00 31.74 ? 373 GLN A O 1 ATOM 2923 C CB . GLN A 1 357 ? 16.834 -3.753 20.358 1.00 31.35 ? 373 GLN A CB 1 ATOM 2924 C CG . GLN A 1 357 ? 16.292 -4.238 21.711 1.00 31.88 ? 373 GLN A CG 1 ATOM 2925 C CD . GLN A 1 357 ? 14.768 -4.247 21.789 1.00 32.86 ? 373 GLN A CD 1 ATOM 2926 O OE1 . GLN A 1 357 ? 14.196 -4.017 22.860 1.00 31.84 ? 373 GLN A OE1 1 ATOM 2927 N NE2 . GLN A 1 357 ? 14.104 -4.509 20.653 1.00 31.74 ? 373 GLN A NE2 1 ATOM 2928 N N . TYR A 1 358 ? 18.458 -1.068 20.813 1.00 31.12 ? 374 TYR A N 1 ATOM 2929 C CA . TYR A 1 358 ? 19.208 -0.160 21.679 1.00 31.01 ? 374 TYR A CA 1 ATOM 2930 C C . TYR A 1 358 ? 18.579 1.233 21.632 1.00 30.87 ? 374 TYR A C 1 ATOM 2931 O O . TYR A 1 358 ? 18.309 1.823 22.681 1.00 30.14 ? 374 TYR A O 1 ATOM 2932 C CB . TYR A 1 358 ? 20.690 -0.112 21.274 1.00 31.11 ? 374 TYR A CB 1 ATOM 2933 C CG . TYR A 1 358 ? 21.696 0.037 22.419 1.00 30.77 ? 374 TYR A CG 1 ATOM 2934 C CD1 . TYR A 1 358 ? 21.320 0.557 23.663 1.00 31.18 ? 374 TYR A CD1 1 ATOM 2935 C CD2 . TYR A 1 358 ? 23.022 -0.354 22.251 1.00 30.31 ? 374 TYR A CD2 1 ATOM 2936 C CE1 . TYR A 1 358 ? 22.248 0.695 24.703 1.00 30.12 ? 374 TYR A CE1 1 ATOM 2937 C CE2 . TYR A 1 358 ? 23.956 -0.224 23.277 1.00 29.36 ? 374 TYR A CE2 1 ATOM 2938 C CZ . TYR A 1 358 ? 23.563 0.301 24.501 1.00 30.38 ? 374 TYR A CZ 1 ATOM 2939 O OH . TYR A 1 358 ? 24.489 0.424 25.515 1.00 28.36 ? 374 TYR A OH 1 ATOM 2940 N N . PHE A 1 359 ? 18.318 1.726 20.419 1.00 30.75 ? 375 PHE A N 1 ATOM 2941 C CA . PHE A 1 359 ? 17.627 3.007 20.200 1.00 31.33 ? 375 PHE A CA 1 ATOM 2942 C C . PHE A 1 359 ? 16.329 3.121 20.994 1.00 31.72 ? 375 PHE A C 1 ATOM 2943 O O . PHE A 1 359 ? 16.085 4.135 21.660 1.00 31.91 ? 375 PHE A O 1 ATOM 2944 C CB . PHE A 1 359 ? 17.276 3.220 18.720 1.00 31.13 ? 375 PHE A CB 1 ATOM 2945 C CG . PHE A 1 359 ? 18.455 3.274 17.794 1.00 31.34 ? 375 PHE A CG 1 ATOM 2946 C CD1 . PHE A 1 359 ? 19.717 3.671 18.239 1.00 31.44 ? 375 PHE A CD1 1 ATOM 2947 C CD2 . PHE A 1 359 ? 18.287 2.974 16.440 1.00 30.77 ? 375 PHE A CD2 1 ATOM 2948 C CE1 . PHE A 1 359 ? 20.799 3.733 17.353 1.00 31.06 ? 375 PHE A CE1 1 ATOM 2949 C CE2 . PHE A 1 359 ? 19.358 3.029 15.560 1.00 30.24 ? 375 PHE A CE2 1 ATOM 2950 C CZ . PHE A 1 359 ? 20.613 3.412 16.016 1.00 30.44 ? 375 PHE A CZ 1 ATOM 2951 N N . LEU A 1 360 ? 15.493 2.087 20.902 1.00 31.88 ? 376 LEU A N 1 ATOM 2952 C CA . LEU A 1 360 ? 14.189 2.102 21.555 1.00 32.25 ? 376 LEU A CA 1 ATOM 2953 C C . LEU A 1 360 ? 14.329 2.052 23.070 1.00 32.49 ? 376 LEU A C 1 ATOM 2954 O O . LEU A 1 360 ? 13.576 2.715 23.787 1.00 32.68 ? 376 LEU A O 1 ATOM 2955 C CB . LEU A 1 360 ? 13.316 0.940 21.065 1.00 32.32 ? 376 LEU A CB 1 ATOM 2956 C CG . LEU A 1 360 ? 12.939 0.913 19.577 1.00 32.53 ? 376 LEU A CG 1 ATOM 2957 C CD1 . LEU A 1 360 ? 12.320 -0.428 19.221 1.00 32.01 ? 376 LEU A CD1 1 ATOM 2958 C CD2 . LEU A 1 360 ? 11.996 2.066 19.205 1.00 32.82 ? 376 LEU A CD2 1 ATOM 2959 N N . GLN A 1 361 ? 15.299 1.278 23.548 1.00 32.38 ? 377 GLN A N 1 ATOM 2960 C CA . GLN A 1 361 ? 15.503 1.100 24.986 1.00 32.86 ? 377 GLN A CA 1 ATOM 2961 C C . GLN A 1 361 ? 15.929 2.382 25.697 1.00 32.98 ? 377 GLN A C 1 ATOM 2962 O O . GLN A 1 361 ? 15.571 2.596 26.859 1.00 33.25 ? 377 GLN A O 1 ATOM 2963 C CB . GLN A 1 361 ? 16.516 -0.014 25.265 1.00 32.59 ? 377 GLN A CB 1 ATOM 2964 C CG . GLN A 1 361 ? 15.999 -1.430 24.994 1.00 33.45 ? 377 GLN A CG 1 ATOM 2965 C CD . GLN A 1 361 ? 15.101 -1.966 26.100 1.00 34.36 ? 377 GLN A CD 1 ATOM 2966 O OE1 . GLN A 1 361 ? 15.271 -1.631 27.274 1.00 34.55 ? 377 GLN A OE1 1 ATOM 2967 N NE2 . GLN A 1 361 ? 14.148 -2.814 25.729 1.00 34.05 ? 377 GLN A NE2 1 ATOM 2968 N N . TYR A 1 362 ? 16.692 3.232 25.009 1.00 33.01 ? 378 TYR A N 1 ATOM 2969 C CA . TYR A 1 362 ? 17.185 4.461 25.630 1.00 33.09 ? 378 TYR A CA 1 ATOM 2970 C C . TYR A 1 362 ? 16.555 5.762 25.130 1.00 33.24 ? 378 TYR A C 1 ATOM 2971 O O . TYR A 1 362 ? 17.023 6.848 25.481 1.00 33.35 ? 378 TYR A O 1 ATOM 2972 C CB . TYR A 1 362 ? 18.726 4.531 25.614 1.00 32.94 ? 378 TYR A CB 1 ATOM 2973 C CG . TYR A 1 362 ? 19.439 4.586 24.263 1.00 32.22 ? 378 TYR A CG 1 ATOM 2974 C CD1 . TYR A 1 362 ? 19.018 5.434 23.230 1.00 31.72 ? 378 TYR A CD1 1 ATOM 2975 C CD2 . TYR A 1 362 ? 20.588 3.826 24.052 1.00 31.88 ? 378 TYR A CD2 1 ATOM 2976 C CE1 . TYR A 1 362 ? 19.713 5.481 22.004 1.00 31.38 ? 378 TYR A CE1 1 ATOM 2977 C CE2 . TYR A 1 362 ? 21.279 3.869 22.849 1.00 31.03 ? 378 TYR A CE2 1 ATOM 2978 C CZ . TYR A 1 362 ? 20.850 4.692 21.833 1.00 31.46 ? 378 TYR A CZ 1 ATOM 2979 O OH . TYR A 1 362 ? 21.573 4.709 20.655 1.00 30.86 ? 378 TYR A OH 1 ATOM 2980 N N . GLN A 1 363 ? 15.488 5.659 24.339 1.00 33.35 ? 379 GLN A N 1 ATOM 2981 C CA . GLN A 1 363 ? 14.875 6.851 23.738 1.00 33.69 ? 379 GLN A CA 1 ATOM 2982 C C . GLN A 1 363 ? 14.211 7.803 24.747 1.00 33.76 ? 379 GLN A C 1 ATOM 2983 O O . GLN A 1 363 ? 13.907 8.939 24.410 1.00 33.64 ? 379 GLN A O 1 ATOM 2984 C CB . GLN A 1 363 ? 13.914 6.479 22.600 1.00 33.71 ? 379 GLN A CB 1 ATOM 2985 C CG . GLN A 1 363 ? 12.592 5.852 23.021 1.00 34.60 ? 379 GLN A CG 1 ATOM 2986 C CD . GLN A 1 363 ? 11.705 5.504 21.832 1.00 35.82 ? 379 GLN A CD 1 ATOM 2987 O OE1 . GLN A 1 363 ? 11.962 5.915 20.694 1.00 35.59 ? 379 GLN A OE1 1 ATOM 2988 N NE2 . GLN A 1 363 ? 10.656 4.739 22.093 1.00 36.65 ? 379 GLN A NE2 1 ATOM 2989 N N . HIS A 1 364 ? 14.005 7.332 25.974 1.00 33.97 ? 380 HIS A N 1 ATOM 2990 C CA . HIS A 1 364 ? 13.475 8.156 27.061 1.00 34.59 ? 380 HIS A CA 1 ATOM 2991 C C . HIS A 1 364 ? 14.579 8.946 27.774 1.00 34.85 ? 380 HIS A C 1 ATOM 2992 O O . HIS A 1 364 ? 14.286 9.817 28.594 1.00 34.99 ? 380 HIS A O 1 ATOM 2993 C CB . HIS A 1 364 ? 12.764 7.269 28.086 1.00 34.63 ? 380 HIS A CB 1 ATOM 2994 C CG . HIS A 1 364 ? 13.692 6.369 28.842 1.00 35.15 ? 380 HIS A CG 1 ATOM 2995 N ND1 . HIS A 1 364 ? 14.388 5.342 28.240 1.00 34.84 ? 380 HIS A ND1 1 ATOM 2996 C CD2 . HIS A 1 364 ? 14.049 6.350 30.150 1.00 35.42 ? 380 HIS A CD2 1 ATOM 2997 C CE1 . HIS A 1 364 ? 15.129 4.726 29.144 1.00 35.18 ? 380 HIS A CE1 1 ATOM 2998 N NE2 . HIS A 1 364 ? 14.941 5.318 30.311 1.00 35.31 ? 380 HIS A NE2 1 ATOM 2999 N N . GLN A 1 365 ? 15.839 8.623 27.479 1.00 34.70 ? 381 GLN A N 1 ATOM 3000 C CA . GLN A 1 365 ? 16.986 9.295 28.102 1.00 34.59 ? 381 GLN A CA 1 ATOM 3001 C C . GLN A 1 365 ? 17.188 10.704 27.543 1.00 34.56 ? 381 GLN A C 1 ATOM 3002 O O . GLN A 1 365 ? 16.784 10.983 26.410 1.00 34.72 ? 381 GLN A O 1 ATOM 3003 C CB . GLN A 1 365 ? 18.272 8.470 27.909 1.00 34.43 ? 381 GLN A CB 1 ATOM 3004 C CG . GLN A 1 365 ? 18.298 7.123 28.643 1.00 34.31 ? 381 GLN A CG 1 ATOM 3005 C CD . GLN A 1 365 ? 18.712 7.232 30.108 1.00 35.17 ? 381 GLN A CD 1 ATOM 3006 O OE1 . GLN A 1 365 ? 18.568 6.276 30.881 1.00 35.39 ? 381 GLN A OE1 1 ATOM 3007 N NE2 . GLN A 1 365 ? 19.237 8.390 30.493 1.00 34.13 ? 381 GLN A NE2 1 ATOM 3008 N N . PRO A 1 366 ? 17.813 11.604 28.332 1.00 34.50 ? 382 PRO A N 1 ATOM 3009 C CA . PRO A 1 366 ? 18.251 12.886 27.782 1.00 34.59 ? 382 PRO A CA 1 ATOM 3010 C C . PRO A 1 366 ? 19.038 12.666 26.490 1.00 34.48 ? 382 PRO A C 1 ATOM 3011 O O . PRO A 1 366 ? 19.754 11.671 26.381 1.00 34.47 ? 382 PRO A O 1 ATOM 3012 C CB . PRO A 1 366 ? 19.197 13.420 28.860 1.00 34.66 ? 382 PRO A CB 1 ATOM 3013 C CG . PRO A 1 366 ? 18.700 12.833 30.126 1.00 34.50 ? 382 PRO A CG 1 ATOM 3014 C CD . PRO A 1 366 ? 18.054 11.517 29.787 1.00 34.76 ? 382 PRO A CD 1 ATOM 3015 N N . PHE A 1 367 ? 18.915 13.590 25.539 1.00 34.49 ? 383 PHE A N 1 ATOM 3016 C CA . PHE A 1 367 ? 19.570 13.468 24.232 1.00 34.70 ? 383 PHE A CA 1 ATOM 3017 C C . PHE A 1 367 ? 21.021 12.982 24.303 1.00 34.66 ? 383 PHE A C 1 ATOM 3018 O O . PHE A 1 367 ? 21.408 12.066 23.574 1.00 34.47 ? 383 PHE A O 1 ATOM 3019 C CB . PHE A 1 367 ? 19.514 14.787 23.461 1.00 34.81 ? 383 PHE A CB 1 ATOM 3020 C CG . PHE A 1 367 ? 20.331 14.779 22.198 1.00 35.57 ? 383 PHE A CG 1 ATOM 3021 C CD1 . PHE A 1 367 ? 19.860 14.137 21.057 1.00 36.07 ? 383 PHE A CD1 1 ATOM 3022 C CD2 . PHE A 1 367 ? 21.579 15.391 22.155 1.00 35.85 ? 383 PHE A CD2 1 ATOM 3023 C CE1 . PHE A 1 367 ? 20.616 14.118 19.886 1.00 36.58 ? 383 PHE A CE1 1 ATOM 3024 C CE2 . PHE A 1 367 ? 22.344 15.375 20.990 1.00 36.83 ? 383 PHE A CE2 1 ATOM 3025 C CZ . PHE A 1 367 ? 21.859 14.738 19.853 1.00 36.39 ? 383 PHE A CZ 1 ATOM 3026 N N . VAL A 1 368 ? 21.816 13.598 25.177 1.00 34.41 ? 384 VAL A N 1 ATOM 3027 C CA . VAL A 1 368 ? 23.250 13.282 25.268 1.00 34.29 ? 384 VAL A CA 1 ATOM 3028 C C . VAL A 1 368 ? 23.526 11.851 25.744 1.00 34.00 ? 384 VAL A C 1 ATOM 3029 O O . VAL A 1 368 ? 24.624 11.329 25.552 1.00 34.39 ? 384 VAL A O 1 ATOM 3030 C CB . VAL A 1 368 ? 24.043 14.306 26.140 1.00 34.28 ? 384 VAL A CB 1 ATOM 3031 C CG1 . VAL A 1 368 ? 24.016 15.688 25.502 1.00 34.27 ? 384 VAL A CG1 1 ATOM 3032 C CG2 . VAL A 1 368 ? 23.519 14.344 27.581 1.00 34.64 ? 384 VAL A CG2 1 ATOM 3033 N N . TYR A 1 369 ? 22.527 11.225 26.355 1.00 33.53 ? 385 TYR A N 1 ATOM 3034 C CA . TYR A 1 369 ? 22.648 9.850 26.827 1.00 33.27 ? 385 TYR A CA 1 ATOM 3035 C C . TYR A 1 369 ? 22.057 8.832 25.833 1.00 33.16 ? 385 TYR A C 1 ATOM 3036 O O . TYR A 1 369 ? 22.126 7.620 26.056 1.00 32.96 ? 385 TYR A O 1 ATOM 3037 C CB . TYR A 1 369 ? 21.986 9.695 28.197 1.00 33.35 ? 385 TYR A CB 1 ATOM 3038 C CG . TYR A 1 369 ? 22.687 10.402 29.355 1.00 33.60 ? 385 TYR A CG 1 ATOM 3039 C CD1 . TYR A 1 369 ? 24.026 10.807 29.266 1.00 33.10 ? 385 TYR A CD1 1 ATOM 3040 C CD2 . TYR A 1 369 ? 22.009 10.628 30.558 1.00 34.05 ? 385 TYR A CD2 1 ATOM 3041 C CE1 . TYR A 1 369 ? 24.662 11.438 30.342 1.00 33.57 ? 385 TYR A CE1 1 ATOM 3042 C CE2 . TYR A 1 369 ? 22.633 11.247 31.638 1.00 34.19 ? 385 TYR A CE2 1 ATOM 3043 C CZ . TYR A 1 369 ? 23.959 11.649 31.529 1.00 34.88 ? 385 TYR A CZ 1 ATOM 3044 O OH . TYR A 1 369 ? 24.572 12.273 32.607 1.00 34.61 ? 385 TYR A OH 1 ATOM 3045 N N . ARG A 1 370 ? 21.493 9.330 24.736 1.00 32.95 ? 386 ARG A N 1 ATOM 3046 C CA . ARG A 1 370 ? 20.868 8.468 23.730 1.00 33.01 ? 386 ARG A CA 1 ATOM 3047 C C . ARG A 1 370 ? 21.913 7.942 22.754 1.00 32.77 ? 386 ARG A C 1 ATOM 3048 O O . ARG A 1 370 ? 21.904 8.256 21.562 1.00 32.85 ? 386 ARG A O 1 ATOM 3049 C CB . ARG A 1 370 ? 19.716 9.185 23.014 1.00 32.71 ? 386 ARG A CB 1 ATOM 3050 C CG . ARG A 1 370 ? 18.526 9.488 23.933 1.00 33.82 ? 386 ARG A CG 1 ATOM 3051 C CD . ARG A 1 370 ? 17.437 10.298 23.249 1.00 34.04 ? 386 ARG A CD 1 ATOM 3052 N NE . ARG A 1 370 ? 16.692 9.510 22.268 1.00 35.11 ? 386 ARG A NE 1 ATOM 3053 C CZ . ARG A 1 370 ? 15.651 9.961 21.573 1.00 35.08 ? 386 ARG A CZ 1 ATOM 3054 N NH1 . ARG A 1 370 ? 15.216 11.204 21.744 1.00 34.26 ? 386 ARG A NH1 1 ATOM 3055 N NH2 . ARG A 1 370 ? 15.044 9.165 20.702 1.00 35.02 ? 386 ARG A NH2 1 ATOM 3056 N N . THR A 1 371 ? 22.822 7.141 23.296 1.00 32.65 ? 387 THR A N 1 ATOM 3057 C CA . THR A 1 371 ? 23.861 6.458 22.530 1.00 32.57 ? 387 THR A CA 1 ATOM 3058 C C . THR A 1 371 ? 24.336 5.272 23.364 1.00 32.09 ? 387 THR A C 1 ATOM 3059 O O . THR A 1 371 ? 23.865 5.082 24.493 1.00 32.34 ? 387 THR A O 1 ATOM 3060 C CB . THR A 1 371 ? 25.030 7.410 22.136 1.00 32.69 ? 387 THR A CB 1 ATOM 3061 O OG1 . THR A 1 371 ? 25.893 6.747 21.206 1.00 33.62 ? 387 THR A OG1 1 ATOM 3062 C CG2 . THR A 1 371 ? 25.837 7.855 23.356 1.00 32.80 ? 387 THR A CG2 1 ATOM 3063 N N . GLY A 1 372 ? 25.252 4.474 22.821 1.00 31.76 ? 388 GLY A N 1 ATOM 3064 C CA . GLY A 1 372 ? 25.739 3.275 23.515 1.00 31.07 ? 388 GLY A CA 1 ATOM 3065 C C . GLY A 1 372 ? 26.587 3.603 24.729 1.00 30.65 ? 388 GLY A C 1 ATOM 3066 O O . GLY A 1 372 ? 27.156 4.685 24.810 1.00 30.71 ? 388 GLY A O 1 ATOM 3067 N N . ALA A 1 373 ? 26.672 2.670 25.673 1.00 30.50 ? 389 ALA A N 1 ATOM 3068 C CA . ALA A 1 373 ? 27.522 2.845 26.863 1.00 30.24 ? 389 ALA A CA 1 ATOM 3069 C C . ALA A 1 373 ? 28.974 3.108 26.441 1.00 29.98 ? 389 ALA A C 1 ATOM 3070 O O . ALA A 1 373 ? 29.658 3.967 27.009 1.00 29.53 ? 389 ALA A O 1 ATOM 3071 C CB . ALA A 1 373 ? 27.428 1.631 27.772 1.00 29.91 ? 389 ALA A CB 1 ATOM 3072 N N . ASN A 1 374 ? 29.429 2.347 25.445 1.00 29.54 ? 390 ASN A N 1 ATOM 3073 C CA . ASN A 1 374 ? 30.559 2.745 24.601 1.00 29.40 ? 390 ASN A CA 1 ATOM 3074 C C . ASN A 1 374 ? 30.313 2.224 23.165 1.00 29.16 ? 390 ASN A C 1 ATOM 3075 O O . ASN A 1 374 ? 29.389 1.447 22.952 1.00 28.82 ? 390 ASN A O 1 ATOM 3076 C CB . ASN A 1 374 ? 31.928 2.359 25.214 1.00 29.11 ? 390 ASN A CB 1 ATOM 3077 C CG . ASN A 1 374 ? 32.247 0.877 25.117 1.00 29.87 ? 390 ASN A CG 1 ATOM 3078 O OD1 . ASN A 1 374 ? 32.068 0.250 24.075 1.00 30.84 ? 390 ASN A OD1 1 ATOM 3079 N ND2 . ASN A 1 374 ? 32.772 0.318 26.206 1.00 29.92 ? 390 ASN A ND2 1 ATOM 3080 N N . PRO A 1 375 ? 31.101 2.674 22.173 1.00 29.34 ? 391 PRO A N 1 ATOM 3081 C CA . PRO A 1 375 ? 30.777 2.225 20.806 1.00 29.19 ? 391 PRO A CA 1 ATOM 3082 C C . PRO A 1 375 ? 30.703 0.700 20.634 1.00 29.39 ? 391 PRO A C 1 ATOM 3083 O O . PRO A 1 375 ? 29.910 0.216 19.824 1.00 29.40 ? 391 PRO A O 1 ATOM 3084 C CB . PRO A 1 375 ? 31.912 2.821 19.973 1.00 29.33 ? 391 PRO A CB 1 ATOM 3085 C CG . PRO A 1 375 ? 32.261 4.072 20.697 1.00 29.39 ? 391 PRO A CG 1 ATOM 3086 C CD . PRO A 1 375 ? 32.144 3.718 22.168 1.00 29.02 ? 391 PRO A CD 1 ATOM 3087 N N . GLY A 1 376 ? 31.501 -0.045 21.400 1.00 29.10 ? 392 GLY A N 1 ATOM 3088 C CA . GLY A 1 376 ? 31.479 -1.508 21.344 1.00 29.35 ? 392 GLY A CA 1 ATOM 3089 C C . GLY A 1 376 ? 30.180 -2.144 21.817 1.00 29.66 ? 392 GLY A C 1 ATOM 3090 O O . GLY A 1 376 ? 29.769 -3.180 21.291 1.00 29.63 ? 392 GLY A O 1 ATOM 3091 N N . PHE A 1 377 ? 29.535 -1.533 22.814 1.00 30.00 ? 393 PHE A N 1 ATOM 3092 C CA . PHE A 1 377 ? 28.261 -2.032 23.333 1.00 30.13 ? 393 PHE A CA 1 ATOM 3093 C C . PHE A 1 377 ? 27.202 -2.055 22.235 1.00 30.26 ? 393 PHE A C 1 ATOM 3094 O O . PHE A 1 377 ? 26.482 -3.041 22.078 1.00 30.37 ? 393 PHE A O 1 ATOM 3095 C CB . PHE A 1 377 ? 27.781 -1.181 24.513 1.00 30.22 ? 393 PHE A CB 1 ATOM 3096 C CG . PHE A 1 377 ? 28.387 -1.572 25.839 1.00 30.26 ? 393 PHE A CG 1 ATOM 3097 C CD1 . PHE A 1 377 ? 29.761 -1.515 26.039 1.00 30.40 ? 393 PHE A CD1 1 ATOM 3098 C CD2 . PHE A 1 377 ? 27.577 -1.997 26.887 1.00 30.14 ? 393 PHE A CD2 1 ATOM 3099 C CE1 . PHE A 1 377 ? 30.324 -1.874 27.260 1.00 31.13 ? 393 PHE A CE1 1 ATOM 3100 C CE2 . PHE A 1 377 ? 28.131 -2.357 28.114 1.00 30.59 ? 393 PHE A CE2 1 ATOM 3101 C CZ . PHE A 1 377 ? 29.505 -2.290 28.301 1.00 30.74 ? 393 PHE A CZ 1 ATOM 3102 N N . HIS A 1 378 ? 27.127 -0.980 21.459 1.00 30.51 ? 394 HIS A N 1 ATOM 3103 C CA . HIS A 1 378 ? 26.132 -0.884 20.394 1.00 30.86 ? 394 HIS A CA 1 ATOM 3104 C C . HIS A 1 378 ? 26.280 -2.014 19.380 1.00 31.05 ? 394 HIS A C 1 ATOM 3105 O O . HIS A 1 378 ? 25.284 -2.597 18.946 1.00 31.46 ? 394 HIS A O 1 ATOM 3106 C CB . HIS A 1 378 ? 26.201 0.473 19.693 1.00 30.79 ? 394 HIS A CB 1 ATOM 3107 C CG . HIS A 1 378 ? 24.889 1.193 19.656 1.00 31.06 ? 394 HIS A CG 1 ATOM 3108 N ND1 . HIS A 1 378 ? 23.802 0.725 18.949 1.00 31.04 ? 394 HIS A ND1 1 ATOM 3109 C CD2 . HIS A 1 378 ? 24.486 2.341 20.251 1.00 30.40 ? 394 HIS A CD2 1 ATOM 3110 C CE1 . HIS A 1 378 ? 22.789 1.556 19.106 1.00 31.41 ? 394 HIS A CE1 1 ATOM 3111 N NE2 . HIS A 1 378 ? 23.176 2.543 19.895 1.00 31.04 ? 394 HIS A NE2 1 ATOM 3112 N N . GLU A 1 379 ? 27.521 -2.332 19.020 1.00 31.12 ? 395 GLU A N 1 ATOM 3113 C CA . GLU A 1 379 ? 27.784 -3.356 18.006 1.00 31.08 ? 395 GLU A CA 1 ATOM 3114 C C . GLU A 1 379 ? 27.582 -4.782 18.536 1.00 30.96 ? 395 GLU A C 1 ATOM 3115 O O . GLU A 1 379 ? 27.338 -5.707 17.760 1.00 31.11 ? 395 GLU A O 1 ATOM 3116 C CB . GLU A 1 379 ? 29.202 -3.188 17.424 1.00 31.26 ? 395 GLU A CB 1 ATOM 3117 C CG . GLU A 1 379 ? 29.531 -1.778 16.902 1.00 31.17 ? 395 GLU A CG 1 ATOM 3118 C CD . GLU A 1 379 ? 28.626 -1.332 15.761 1.00 31.80 ? 395 GLU A CD 1 ATOM 3119 O OE1 . GLU A 1 379 ? 28.166 -2.199 15.000 1.00 31.54 ? 395 GLU A OE1 1 ATOM 3120 O OE2 . GLU A 1 379 ? 28.387 -0.113 15.614 1.00 31.88 ? 395 GLU A OE2 1 ATOM 3121 N N . ALA A 1 380 ? 27.675 -4.951 19.856 1.00 30.73 ? 396 ALA A N 1 ATOM 3122 C CA . ALA A 1 380 ? 27.591 -6.273 20.482 1.00 30.55 ? 396 ALA A CA 1 ATOM 3123 C C . ALA A 1 380 ? 26.172 -6.844 20.578 1.00 30.59 ? 396 ALA A C 1 ATOM 3124 O O . ALA A 1 380 ? 25.992 -8.065 20.510 1.00 30.34 ? 396 ALA A O 1 ATOM 3125 C CB . ALA A 1 380 ? 28.244 -6.256 21.870 1.00 30.30 ? 396 ALA A CB 1 ATOM 3126 N N . VAL A 1 381 ? 25.181 -5.967 20.735 1.00 30.69 ? 397 VAL A N 1 ATOM 3127 C CA . VAL A 1 381 ? 23.813 -6.389 21.064 1.00 31.00 ? 397 VAL A CA 1 ATOM 3128 C C . VAL A 1 381 ? 23.264 -7.407 20.066 1.00 31.00 ? 397 VAL A C 1 ATOM 3129 O O . VAL A 1 381 ? 22.883 -8.512 20.451 1.00 30.92 ? 397 VAL A O 1 ATOM 3130 C CB . VAL A 1 381 ? 22.825 -5.191 21.181 1.00 30.95 ? 397 VAL A CB 1 ATOM 3131 C CG1 . VAL A 1 381 ? 21.436 -5.685 21.567 1.00 30.97 ? 397 VAL A CG1 1 ATOM 3132 C CG2 . VAL A 1 381 ? 23.315 -4.178 22.198 1.00 31.22 ? 397 VAL A CG2 1 ATOM 3133 N N . GLY A 1 382 ? 23.239 -7.031 18.789 1.00 31.01 ? 398 GLY A N 1 ATOM 3134 C CA . GLY A 1 382 ? 22.696 -7.896 17.753 1.00 31.32 ? 398 GLY A CA 1 ATOM 3135 C C . GLY A 1 382 ? 23.500 -9.167 17.580 1.00 31.49 ? 398 GLY A C 1 ATOM 3136 O O . GLY A 1 382 ? 22.951 -10.213 17.225 1.00 31.83 ? 398 GLY A O 1 ATOM 3137 N N . ASP A 1 383 ? 24.800 -9.081 17.850 1.00 31.59 ? 399 ASP A N 1 ATOM 3138 C CA . ASP A 1 383 ? 25.693 -10.228 17.695 1.00 31.70 ? 399 ASP A CA 1 ATOM 3139 C C . ASP A 1 383 ? 25.463 -11.319 18.728 1.00 31.74 ? 399 ASP A C 1 ATOM 3140 O O . ASP A 1 383 ? 25.648 -12.500 18.432 1.00 31.56 ? 399 ASP A O 1 ATOM 3141 C CB . ASP A 1 383 ? 27.156 -9.781 17.663 1.00 31.57 ? 399 ASP A CB 1 ATOM 3142 C CG . ASP A 1 383 ? 27.588 -9.328 16.278 1.00 32.16 ? 399 ASP A CG 1 ATOM 3143 O OD1 . ASP A 1 383 ? 26.695 -9.174 15.410 1.00 33.95 ? 399 ASP A OD1 1 ATOM 3144 O OD2 . ASP A 1 383 ? 28.804 -9.125 16.050 1.00 31.19 ? 399 ASP A OD2 1 ATOM 3145 N N . VAL A 1 384 ? 25.052 -10.923 19.933 1.00 31.97 ? 400 VAL A N 1 ATOM 3146 C CA . VAL A 1 384 ? 24.652 -11.890 20.958 1.00 31.79 ? 400 VAL A CA 1 ATOM 3147 C C . VAL A 1 384 ? 23.491 -12.756 20.454 1.00 32.27 ? 400 VAL A C 1 ATOM 3148 O O . VAL A 1 384 ? 23.516 -13.980 20.603 1.00 32.32 ? 400 VAL A O 1 ATOM 3149 C CB . VAL A 1 384 ? 24.266 -11.196 22.281 1.00 32.04 ? 400 VAL A CB 1 ATOM 3150 C CG1 . VAL A 1 384 ? 23.879 -12.234 23.338 1.00 31.39 ? 400 VAL A CG1 1 ATOM 3151 C CG2 . VAL A 1 384 ? 25.412 -10.320 22.775 1.00 30.77 ? 400 VAL A CG2 1 ATOM 3152 N N . LEU A 1 385 ? 22.489 -12.126 19.841 1.00 32.65 ? 401 LEU A N 1 ATOM 3153 C CA . LEU A 1 385 ? 21.382 -12.879 19.250 1.00 33.55 ? 401 LEU A CA 1 ATOM 3154 C C . LEU A 1 385 ? 21.852 -13.724 18.059 1.00 33.72 ? 401 LEU A C 1 ATOM 3155 O O . LEU A 1 385 ? 21.490 -14.892 17.953 1.00 34.12 ? 401 LEU A O 1 ATOM 3156 C CB . LEU A 1 385 ? 20.208 -11.978 18.837 1.00 33.59 ? 401 LEU A CB 1 ATOM 3157 C CG . LEU A 1 385 ? 19.504 -10.958 19.753 1.00 34.66 ? 401 LEU A CG 1 ATOM 3158 C CD1 . LEU A 1 385 ? 18.028 -10.910 19.378 1.00 34.36 ? 401 LEU A CD1 1 ATOM 3159 C CD2 . LEU A 1 385 ? 19.655 -11.195 21.258 1.00 34.68 ? 401 LEU A CD2 1 ATOM 3160 N N . SER A 1 386 ? 22.671 -13.140 17.186 1.00 33.83 ? 402 SER A N 1 ATOM 3161 C CA . SER A 1 386 ? 23.205 -13.867 16.026 1.00 34.06 ? 402 SER A CA 1 ATOM 3162 C C . SER A 1 386 ? 24.012 -15.105 16.427 1.00 33.92 ? 402 SER A C 1 ATOM 3163 O O . SER A 1 386 ? 24.029 -16.099 15.698 1.00 34.21 ? 402 SER A O 1 ATOM 3164 C CB . SER A 1 386 ? 24.045 -12.950 15.143 1.00 33.94 ? 402 SER A CB 1 ATOM 3165 O OG . SER A 1 386 ? 23.223 -12.032 14.439 1.00 34.70 ? 402 SER A OG 1 ATOM 3166 N N . LEU A 1 387 ? 24.670 -15.044 17.582 1.00 33.52 ? 403 LEU A N 1 ATOM 3167 C CA . LEU A 1 387 ? 25.370 -16.212 18.116 1.00 33.37 ? 403 LEU A CA 1 ATOM 3168 C C . LEU A 1 387 ? 24.402 -17.368 18.382 1.00 33.45 ? 403 LEU A C 1 ATOM 3169 O O . LEU A 1 387 ? 24.704 -18.519 18.047 1.00 33.32 ? 403 LEU A O 1 ATOM 3170 C CB . LEU A 1 387 ? 26.182 -15.861 19.369 1.00 32.77 ? 403 LEU A CB 1 ATOM 3171 C CG . LEU A 1 387 ? 27.615 -15.349 19.152 1.00 33.05 ? 403 LEU A CG 1 ATOM 3172 C CD1 . LEU A 1 387 ? 28.230 -14.836 20.461 1.00 32.17 ? 403 LEU A CD1 1 ATOM 3173 C CD2 . LEU A 1 387 ? 28.526 -16.416 18.521 1.00 32.15 ? 403 LEU A CD2 1 ATOM 3174 N N . SER A 1 388 ? 23.246 -17.044 18.966 1.00 33.45 ? 404 SER A N 1 ATOM 3175 C CA . SER A 1 388 ? 22.164 -18.008 19.193 1.00 33.88 ? 404 SER A CA 1 ATOM 3176 C C . SER A 1 388 ? 21.500 -18.450 17.896 1.00 33.68 ? 404 SER A C 1 ATOM 3177 O O . SER A 1 388 ? 21.232 -19.633 17.713 1.00 33.82 ? 404 SER A O 1 ATOM 3178 C CB . SER A 1 388 ? 21.097 -17.429 20.129 1.00 33.69 ? 404 SER A CB 1 ATOM 3179 O OG . SER A 1 388 ? 21.437 -17.663 21.484 1.00 35.42 ? 404 SER A OG 1 ATOM 3180 N N . VAL A 1 389 ? 21.226 -17.493 17.013 1.00 33.91 ? 405 VAL A N 1 ATOM 3181 C CA . VAL A 1 389 ? 20.599 -17.777 15.720 1.00 34.24 ? 405 VAL A CA 1 ATOM 3182 C C . VAL A 1 389 ? 21.430 -18.790 14.927 1.00 34.28 ? 405 VAL A C 1 ATOM 3183 O O . VAL A 1 389 ? 20.876 -19.641 14.237 1.00 34.53 ? 405 VAL A O 1 ATOM 3184 C CB . VAL A 1 389 ? 20.384 -16.484 14.882 1.00 34.45 ? 405 VAL A CB 1 ATOM 3185 C CG1 . VAL A 1 389 ? 19.872 -16.811 13.481 1.00 34.31 ? 405 VAL A CG1 1 ATOM 3186 C CG2 . VAL A 1 389 ? 19.412 -15.527 15.586 1.00 34.35 ? 405 VAL A CG2 1 ATOM 3187 N N . SER A 1 390 ? 22.752 -18.704 15.066 1.00 34.19 ? 406 SER A N 1 ATOM 3188 C CA . SER A 1 390 ? 23.694 -19.543 14.318 1.00 33.95 ? 406 SER A CA 1 ATOM 3189 C C . SER A 1 390 ? 23.796 -20.990 14.809 1.00 34.01 ? 406 SER A C 1 ATOM 3190 O O . SER A 1 390 ? 24.305 -21.851 14.082 1.00 33.82 ? 406 SER A O 1 ATOM 3191 C CB . SER A 1 390 ? 25.090 -18.909 14.340 1.00 34.01 ? 406 SER A CB 1 ATOM 3192 O OG . SER A 1 390 ? 25.729 -19.125 15.589 1.00 32.98 ? 406 SER A OG 1 ATOM 3193 N N . THR A 1 391 ? 23.347 -21.253 16.039 1.00 33.85 ? 407 THR A N 1 ATOM 3194 C CA . THR A 1 391 ? 23.453 -22.595 16.617 1.00 33.74 ? 407 THR A CA 1 ATOM 3195 C C . THR A 1 391 ? 22.586 -23.605 15.873 1.00 34.19 ? 407 THR A C 1 ATOM 3196 O O . THR A 1 391 ? 21.497 -23.258 15.399 1.00 34.06 ? 407 THR A O 1 ATOM 3197 C CB . THR A 1 391 ? 23.059 -22.643 18.119 1.00 33.74 ? 407 THR A CB 1 ATOM 3198 O OG1 . THR A 1 391 ? 21.685 -22.269 18.272 1.00 32.77 ? 407 THR A OG1 1 ATOM 3199 C CG2 . THR A 1 391 ? 23.947 -21.729 18.950 1.00 33.08 ? 407 THR A CG2 1 ATOM 3200 N N . PRO A 1 392 ? 23.070 -24.859 15.765 1.00 34.51 ? 408 PRO A N 1 ATOM 3201 C CA . PRO A 1 392 ? 22.237 -25.947 15.255 1.00 34.88 ? 408 PRO A CA 1 ATOM 3202 C C . PRO A 1 392 ? 20.916 -26.052 16.020 1.00 35.27 ? 408 PRO A C 1 ATOM 3203 O O . PRO A 1 392 ? 19.873 -26.279 15.407 1.00 35.74 ? 408 PRO A O 1 ATOM 3204 C CB . PRO A 1 392 ? 23.101 -27.188 15.495 1.00 34.74 ? 408 PRO A CB 1 ATOM 3205 C CG . PRO A 1 392 ? 24.492 -26.682 15.413 1.00 34.68 ? 408 PRO A CG 1 ATOM 3206 C CD . PRO A 1 392 ? 24.453 -25.304 16.025 1.00 34.45 ? 408 PRO A CD 1 ATOM 3207 N N . LYS A 1 393 ? 20.962 -25.862 17.337 1.00 35.41 ? 409 LYS A N 1 ATOM 3208 C CA . LYS A 1 393 ? 19.754 -25.854 18.161 1.00 35.72 ? 409 LYS A CA 1 ATOM 3209 C C . LYS A 1 393 ? 18.670 -24.933 17.593 1.00 35.64 ? 409 LYS A C 1 ATOM 3210 O O . LYS A 1 393 ? 17.553 -25.378 17.326 1.00 35.71 ? 409 LYS A O 1 ATOM 3211 C CB . LYS A 1 393 ? 20.080 -25.462 19.602 1.00 35.71 ? 409 LYS A CB 1 ATOM 3212 C CG . LYS A 1 393 ? 18.857 -25.416 20.519 1.00 36.93 ? 409 LYS A CG 1 ATOM 3213 C CD . LYS A 1 393 ? 19.241 -25.097 21.964 1.00 39.04 ? 409 LYS A CD 1 ATOM 3214 C CE . LYS A 1 393 ? 19.830 -26.309 22.672 1.00 40.19 ? 409 LYS A CE 1 ATOM 3215 N NZ . LYS A 1 393 ? 20.684 -25.898 23.818 1.00 41.87 ? 409 LYS A NZ 1 ATOM 3216 N N . HIS A 1 394 ? 19.003 -23.660 17.396 1.00 35.46 ? 410 HIS A N 1 ATOM 3217 C CA . HIS A 1 394 ? 18.025 -22.700 16.905 1.00 35.44 ? 410 HIS A CA 1 ATOM 3218 C C . HIS A 1 394 ? 17.607 -22.951 15.458 1.00 35.64 ? 410 HIS A C 1 ATOM 3219 O O . HIS A 1 394 ? 16.426 -22.843 15.126 1.00 35.35 ? 410 HIS A O 1 ATOM 3220 C CB . HIS A 1 394 ? 18.526 -21.261 17.049 1.00 35.51 ? 410 HIS A CB 1 ATOM 3221 C CG . HIS A 1 394 ? 17.490 -20.238 16.707 1.00 35.12 ? 410 HIS A CG 1 ATOM 3222 N ND1 . HIS A 1 394 ? 16.504 -19.857 17.590 1.00 35.35 ? 410 HIS A ND1 1 ATOM 3223 C CD2 . HIS A 1 394 ? 17.261 -19.549 15.565 1.00 35.10 ? 410 HIS A CD2 1 ATOM 3224 C CE1 . HIS A 1 394 ? 15.721 -18.964 17.013 1.00 35.16 ? 410 HIS A CE1 1 ATOM 3225 N NE2 . HIS A 1 394 ? 16.161 -18.757 15.784 1.00 35.34 ? 410 HIS A NE2 1 ATOM 3226 N N . LEU A 1 395 ? 18.572 -23.272 14.600 1.00 36.06 ? 411 LEU A N 1 ATOM 3227 C CA . LEU A 1 395 ? 18.281 -23.438 13.174 1.00 36.61 ? 411 LEU A CA 1 ATOM 3228 C C . LEU A 1 395 ? 17.391 -24.652 12.887 1.00 37.36 ? 411 LEU A C 1 ATOM 3229 O O . LEU A 1 395 ? 16.635 -24.653 11.912 1.00 37.41 ? 411 LEU A O 1 ATOM 3230 C CB . LEU A 1 395 ? 19.568 -23.457 12.342 1.00 36.26 ? 411 LEU A CB 1 ATOM 3231 C CG . LEU A 1 395 ? 20.342 -22.127 12.290 1.00 35.90 ? 411 LEU A CG 1 ATOM 3232 C CD1 . LEU A 1 395 ? 21.728 -22.313 11.678 1.00 35.17 ? 411 LEU A CD1 1 ATOM 3233 C CD2 . LEU A 1 395 ? 19.574 -21.016 11.556 1.00 33.78 ? 411 LEU A CD2 1 ATOM 3234 N N . GLU A 1 396 ? 17.474 -25.665 13.751 1.00 38.39 ? 412 GLU A N 1 ATOM 3235 C CA . GLU A 1 396 ? 16.581 -26.824 13.693 1.00 39.58 ? 412 GLU A CA 1 ATOM 3236 C C . GLU A 1 396 ? 15.158 -26.445 14.085 1.00 39.52 ? 412 GLU A C 1 ATOM 3237 O O . GLU A 1 396 ? 14.212 -26.800 13.382 1.00 39.49 ? 412 GLU A O 1 ATOM 3238 C CB . GLU A 1 396 ? 17.077 -27.953 14.601 1.00 40.09 ? 412 GLU A CB 1 ATOM 3239 C CG . GLU A 1 396 ? 18.157 -28.824 13.981 1.00 42.83 ? 412 GLU A CG 1 ATOM 3240 C CD . GLU A 1 396 ? 18.573 -29.969 14.886 1.00 46.39 ? 412 GLU A CD 1 ATOM 3241 O OE1 . GLU A 1 396 ? 19.314 -29.723 15.868 1.00 48.79 ? 412 GLU A OE1 1 ATOM 3242 O OE2 . GLU A 1 396 ? 18.165 -31.118 14.607 1.00 47.52 ? 412 GLU A OE2 1 ATOM 3243 N N . LYS A 1 397 ? 15.026 -25.736 15.211 1.00 39.64 ? 413 LYS A N 1 ATOM 3244 C CA . LYS A 1 397 ? 13.744 -25.210 15.701 1.00 39.60 ? 413 LYS A CA 1 ATOM 3245 C C . LYS A 1 397 ? 12.947 -24.473 14.628 1.00 39.42 ? 413 LYS A C 1 ATOM 3246 O O . LYS A 1 397 ? 11.738 -24.678 14.494 1.00 39.35 ? 413 LYS A O 1 ATOM 3247 C CB . LYS A 1 397 ? 13.971 -24.232 16.848 1.00 39.67 ? 413 LYS A CB 1 ATOM 3248 C CG . LYS A 1 397 ? 14.168 -24.834 18.206 1.00 40.59 ? 413 LYS A CG 1 ATOM 3249 C CD . LYS A 1 397 ? 14.189 -23.716 19.234 1.00 42.16 ? 413 LYS A CD 1 ATOM 3250 C CE . LYS A 1 397 ? 14.912 -24.145 20.500 1.00 43.35 ? 413 LYS A CE 1 ATOM 3251 N NZ . LYS A 1 397 ? 15.240 -22.956 21.325 1.00 45.21 ? 413 LYS A NZ 1 ATOM 3252 N N . ILE A 1 398 ? 13.624 -23.605 13.880 1.00 38.97 ? 414 ILE A N 1 ATOM 3253 C CA . ILE A 1 398 ? 12.953 -22.780 12.881 1.00 38.93 ? 414 ILE A CA 1 ATOM 3254 C C . ILE A 1 398 ? 12.855 -23.470 11.520 1.00 39.08 ? 414 ILE A C 1 ATOM 3255 O O . ILE A 1 398 ? 12.400 -22.868 10.550 1.00 39.31 ? 414 ILE A O 1 ATOM 3256 C CB . ILE A 1 398 ? 13.573 -21.355 12.770 1.00 38.92 ? 414 ILE A CB 1 ATOM 3257 C CG1 . ILE A 1 398 ? 15.025 -21.413 12.281 1.00 38.42 ? 414 ILE A CG1 1 ATOM 3258 C CG2 . ILE A 1 398 ? 13.473 -20.626 14.115 1.00 38.79 ? 414 ILE A CG2 1 ATOM 3259 C CD1 . ILE A 1 398 ? 15.611 -20.060 11.928 1.00 38.79 ? 414 ILE A CD1 1 ATOM 3260 N N . GLY A 1 399 ? 13.271 -24.732 11.462 1.00 39.16 ? 415 GLY A N 1 ATOM 3261 C CA . GLY A 1 399 ? 13.084 -25.562 10.273 1.00 39.41 ? 415 GLY A CA 1 ATOM 3262 C C . GLY A 1 399 ? 14.028 -25.281 9.119 1.00 39.74 ? 415 GLY A C 1 ATOM 3263 O O . GLY A 1 399 ? 13.731 -25.634 7.976 1.00 39.70 ? 415 GLY A O 1 ATOM 3264 N N . LEU A 1 400 ? 15.170 -24.657 9.408 1.00 39.96 ? 416 LEU A N 1 ATOM 3265 C CA . LEU A 1 400 ? 16.153 -24.339 8.367 1.00 40.42 ? 416 LEU A CA 1 ATOM 3266 C C . LEU A 1 400 ? 17.282 -25.370 8.265 1.00 40.98 ? 416 LEU A C 1 ATOM 3267 O O . LEU A 1 400 ? 17.902 -25.510 7.207 1.00 40.99 ? 416 LEU A O 1 ATOM 3268 C CB . LEU A 1 400 ? 16.726 -22.930 8.558 1.00 40.22 ? 416 LEU A CB 1 ATOM 3269 C CG . LEU A 1 400 ? 15.831 -21.734 8.218 1.00 40.04 ? 416 LEU A CG 1 ATOM 3270 C CD1 . LEU A 1 400 ? 16.589 -20.426 8.455 1.00 39.42 ? 416 LEU A CD1 1 ATOM 3271 C CD2 . LEU A 1 400 ? 15.326 -21.809 6.778 1.00 38.42 ? 416 LEU A CD2 1 ATOM 3272 N N . LEU A 1 401 ? 17.541 -26.077 9.365 1.00 41.62 ? 417 LEU A N 1 ATOM 3273 C CA . LEU A 1 401 ? 18.563 -27.122 9.413 1.00 42.25 ? 417 LEU A CA 1 ATOM 3274 C C . LEU A 1 401 ? 17.931 -28.503 9.599 1.00 43.04 ? 417 LEU A C 1 ATOM 3275 O O . LEU A 1 401 ? 17.320 -28.782 10.634 1.00 43.03 ? 417 LEU A O 1 ATOM 3276 C CB . LEU A 1 401 ? 19.562 -26.839 10.543 1.00 42.04 ? 417 LEU A CB 1 ATOM 3277 C CG . LEU A 1 401 ? 20.728 -27.814 10.734 1.00 41.70 ? 417 LEU A CG 1 ATOM 3278 C CD1 . LEU A 1 401 ? 21.660 -27.806 9.522 1.00 40.86 ? 417 LEU A CD1 1 ATOM 3279 C CD2 . LEU A 1 401 ? 21.489 -27.474 11.998 1.00 41.21 ? 417 LEU A CD2 1 ATOM 3280 N N . LYS A 1 402 ? 18.096 -29.365 8.600 1.00 44.11 ? 418 LYS A N 1 ATOM 3281 C CA . LYS A 1 402 ? 17.431 -30.676 8.584 1.00 45.12 ? 418 LYS A CA 1 ATOM 3282 C C . LYS A 1 402 ? 18.419 -31.841 8.636 1.00 45.56 ? 418 LYS A C 1 ATOM 3283 O O . LYS A 1 402 ? 19.529 -31.748 8.098 1.00 45.86 ? 418 LYS A O 1 ATOM 3284 C CB . LYS A 1 402 ? 16.531 -30.797 7.347 1.00 45.21 ? 418 LYS A CB 1 ATOM 3285 C CG . LYS A 1 402 ? 15.473 -29.694 7.244 1.00 45.95 ? 418 LYS A CG 1 ATOM 3286 C CD . LYS A 1 402 ? 14.572 -29.871 6.032 1.00 46.93 ? 418 LYS A CD 1 ATOM 3287 C CE . LYS A 1 402 ? 13.694 -28.642 5.802 1.00 47.46 ? 418 LYS A CE 1 ATOM 3288 N NZ . LYS A 1 402 ? 12.857 -28.272 6.981 1.00 46.91 ? 418 LYS A NZ 1 ATOM 3289 N N . ASP A 1 403 ? 18.006 -32.926 9.296 1.00 46.06 ? 419 ASP A N 1 ATOM 3290 C CA . ASP A 1 403 ? 18.778 -34.184 9.386 1.00 46.53 ? 419 ASP A CA 1 ATOM 3291 C C . ASP A 1 403 ? 20.157 -34.017 10.039 1.00 46.48 ? 419 ASP A C 1 ATOM 3292 O O . ASP A 1 403 ? 21.119 -34.686 9.653 1.00 46.74 ? 419 ASP A O 1 ATOM 3293 C CB . ASP A 1 403 ? 18.929 -34.847 8.002 1.00 46.84 ? 419 ASP A CB 1 ATOM 3294 C CG . ASP A 1 403 ? 17.624 -34.901 7.222 1.00 47.80 ? 419 ASP A CG 1 ATOM 3295 O OD1 . ASP A 1 403 ? 16.623 -35.447 7.743 1.00 48.12 ? 419 ASP A OD1 1 ATOM 3296 O OD2 . ASP A 1 403 ? 17.606 -34.391 6.076 1.00 49.88 ? 419 ASP A OD2 1 ATOM 3297 N N . TYR A 1 404 ? 20.242 -33.135 11.031 1.00 46.23 ? 420 TYR A N 1 ATOM 3298 C CA . TYR A 1 404 ? 21.509 -32.818 11.683 1.00 45.93 ? 420 TYR A CA 1 ATOM 3299 C C . TYR A 1 404 ? 21.766 -33.736 12.878 1.00 46.22 ? 420 TYR A C 1 ATOM 3300 O O . TYR A 1 404 ? 20.936 -33.828 13.783 1.00 46.11 ? 420 TYR A O 1 ATOM 3301 C CB . TYR A 1 404 ? 21.520 -31.344 12.120 1.00 45.52 ? 420 TYR A CB 1 ATOM 3302 C CG . TYR A 1 404 ? 22.868 -30.824 12.582 1.00 44.48 ? 420 TYR A CG 1 ATOM 3303 C CD1 . TYR A 1 404 ? 23.806 -30.338 11.664 1.00 43.39 ? 420 TYR A CD1 1 ATOM 3304 C CD2 . TYR A 1 404 ? 23.201 -30.802 13.938 1.00 42.77 ? 420 TYR A CD2 1 ATOM 3305 C CE1 . TYR A 1 404 ? 25.044 -29.853 12.087 1.00 42.46 ? 420 TYR A CE1 1 ATOM 3306 C CE2 . TYR A 1 404 ? 24.433 -30.325 14.368 1.00 42.20 ? 420 TYR A CE2 1 ATOM 3307 C CZ . TYR A 1 404 ? 25.349 -29.854 13.440 1.00 42.21 ? 420 TYR A CZ 1 ATOM 3308 O OH . TYR A 1 404 ? 26.565 -29.377 13.869 1.00 41.67 ? 420 TYR A OH 1 ATOM 3309 N N . VAL A 1 405 ? 22.912 -34.415 12.867 1.00 46.43 ? 421 VAL A N 1 ATOM 3310 C CA . VAL A 1 405 ? 23.357 -35.208 14.014 1.00 46.81 ? 421 VAL A CA 1 ATOM 3311 C C . VAL A 1 405 ? 24.516 -34.473 14.682 1.00 47.09 ? 421 VAL A C 1 ATOM 3312 O O . VAL A 1 405 ? 25.550 -34.231 14.052 1.00 47.04 ? 421 VAL A O 1 ATOM 3313 C CB . VAL A 1 405 ? 23.806 -36.642 13.611 1.00 46.90 ? 421 VAL A CB 1 ATOM 3314 C CG1 . VAL A 1 405 ? 24.268 -37.425 14.840 1.00 46.62 ? 421 VAL A CG1 1 ATOM 3315 C CG2 . VAL A 1 405 ? 22.682 -37.389 12.891 1.00 47.01 ? 421 VAL A CG2 1 ATOM 3316 N N . ARG A 1 406 ? 24.343 -34.120 15.954 1.00 47.36 ? 422 ARG A N 1 ATOM 3317 C CA . ARG A 1 406 ? 25.366 -33.368 16.672 1.00 47.52 ? 422 ARG A CA 1 ATOM 3318 C C . ARG A 1 406 ? 26.330 -34.290 17.415 1.00 47.24 ? 422 ARG A C 1 ATOM 3319 O O . ARG A 1 406 ? 26.260 -34.430 18.641 1.00 47.89 ? 422 ARG A O 1 ATOM 3320 C CB . ARG A 1 406 ? 24.742 -32.325 17.615 1.00 47.76 ? 422 ARG A CB 1 ATOM 3321 C CG . ARG A 1 406 ? 25.730 -31.235 18.065 1.00 48.86 ? 422 ARG A CG 1 ATOM 3322 C CD . ARG A 1 406 ? 25.078 -30.180 18.954 1.00 49.71 ? 422 ARG A CD 1 ATOM 3323 N NE . ARG A 1 406 ? 26.040 -29.164 19.390 1.00 50.19 ? 422 ARG A NE 1 ATOM 3324 C CZ . ARG A 1 406 ? 26.737 -29.215 20.525 1.00 50.51 ? 422 ARG A CZ 1 ATOM 3325 N NH1 . ARG A 1 406 ? 26.589 -30.235 21.365 1.00 50.44 ? 422 ARG A NH1 1 ATOM 3326 N NH2 . ARG A 1 406 ? 27.587 -28.240 20.827 1.00 49.97 ? 422 ARG A NH2 1 ATOM 3327 N N . ASP A 1 407 ? 27.223 -34.926 16.663 1.00 46.57 ? 423 ASP A N 1 ATOM 3328 C CA . ASP A 1 407 ? 28.305 -35.708 17.262 1.00 45.75 ? 423 ASP A CA 1 ATOM 3329 C C . ASP A 1 407 ? 29.526 -34.811 17.477 1.00 45.18 ? 423 ASP A C 1 ATOM 3330 O O . ASP A 1 407 ? 29.494 -33.625 17.133 1.00 45.05 ? 423 ASP A O 1 ATOM 3331 C CB . ASP A 1 407 ? 28.641 -36.943 16.409 1.00 45.69 ? 423 ASP A CB 1 ATOM 3332 C CG . ASP A 1 407 ? 28.968 -36.596 14.964 1.00 45.86 ? 423 ASP A CG 1 ATOM 3333 O OD1 . ASP A 1 407 ? 29.468 -35.482 14.707 1.00 45.70 ? 423 ASP A OD1 1 ATOM 3334 O OD2 . ASP A 1 407 ? 28.721 -37.442 14.078 1.00 45.45 ? 423 ASP A OD2 1 ATOM 3335 N N . ASP A 1 408 ? 30.589 -35.374 18.049 1.00 44.33 ? 424 ASP A N 1 ATOM 3336 C CA . ASP A 1 408 ? 31.824 -34.639 18.314 1.00 43.75 ? 424 ASP A CA 1 ATOM 3337 C C . ASP A 1 408 ? 32.407 -33.946 17.079 1.00 43.04 ? 424 ASP A C 1 ATOM 3338 O O . ASP A 1 408 ? 32.968 -32.855 17.181 1.00 42.88 ? 424 ASP A O 1 ATOM 3339 C CB . ASP A 1 408 ? 32.873 -35.580 18.901 1.00 44.14 ? 424 ASP A CB 1 ATOM 3340 C CG . ASP A 1 408 ? 32.555 -36.000 20.326 1.00 45.30 ? 424 ASP A CG 1 ATOM 3341 O OD1 . ASP A 1 408 ? 31.504 -35.589 20.866 1.00 46.21 ? 424 ASP A OD1 1 ATOM 3342 O OD2 . ASP A 1 408 ? 33.371 -36.746 20.907 1.00 47.51 ? 424 ASP A OD2 1 ATOM 3343 N N . GLU A 1 409 ? 32.274 -34.588 15.923 1.00 42.15 ? 425 GLU A N 1 ATOM 3344 C CA . GLU A 1 409 ? 32.865 -34.081 14.686 1.00 41.42 ? 425 GLU A CA 1 ATOM 3345 C C . GLU A 1 409 ? 32.065 -32.916 14.093 1.00 40.48 ? 425 GLU A C 1 ATOM 3346 O O . GLU A 1 409 ? 32.644 -31.929 13.639 1.00 40.69 ? 425 GLU A O 1 ATOM 3347 C CB . GLU A 1 409 ? 33.059 -35.217 13.675 1.00 41.62 ? 425 GLU A CB 1 ATOM 3348 C CG . GLU A 1 409 ? 34.063 -36.272 14.155 1.00 42.82 ? 425 GLU A CG 1 ATOM 3349 C CD . GLU A 1 409 ? 34.377 -37.350 13.124 1.00 44.69 ? 425 GLU A CD 1 ATOM 3350 O OE1 . GLU A 1 409 ? 33.668 -37.458 12.102 1.00 44.50 ? 425 GLU A OE1 1 ATOM 3351 O OE2 . GLU A 1 409 ? 35.353 -38.098 13.347 1.00 46.44 ? 425 GLU A OE2 1 ATOM 3352 N N . ALA A 1 410 ? 30.741 -33.036 14.108 1.00 39.18 ? 426 ALA A N 1 ATOM 3353 C CA . ALA A 1 410 ? 29.859 -31.936 13.732 1.00 38.06 ? 426 ALA A CA 1 ATOM 3354 C C . ALA A 1 410 ? 30.067 -30.721 14.644 1.00 37.07 ? 426 ALA A C 1 ATOM 3355 O O . ALA A 1 410 ? 29.989 -29.585 14.187 1.00 36.76 ? 426 ALA A O 1 ATOM 3356 C CB . ALA A 1 410 ? 28.399 -32.386 13.760 1.00 37.95 ? 426 ALA A CB 1 ATOM 3357 N N . ARG A 1 411 ? 30.334 -30.969 15.926 1.00 35.92 ? 427 ARG A N 1 ATOM 3358 C CA . ARG A 1 411 ? 30.566 -29.889 16.882 1.00 35.25 ? 427 ARG A CA 1 ATOM 3359 C C . ARG A 1 411 ? 31.832 -29.099 16.544 1.00 34.72 ? 427 ARG A C 1 ATOM 3360 O O . ARG A 1 411 ? 31.831 -27.869 16.576 1.00 34.48 ? 427 ARG A O 1 ATOM 3361 C CB . ARG A 1 411 ? 30.648 -30.420 18.318 1.00 35.25 ? 427 ARG A CB 1 ATOM 3362 C CG . ARG A 1 411 ? 30.779 -29.304 19.344 1.00 35.44 ? 427 ARG A CG 1 ATOM 3363 C CD . ARG A 1 411 ? 31.224 -29.801 20.708 1.00 36.41 ? 427 ARG A CD 1 ATOM 3364 N NE . ARG A 1 411 ? 31.175 -28.712 21.676 1.00 36.73 ? 427 ARG A NE 1 ATOM 3365 C CZ . ARG A 1 411 ? 31.638 -28.775 22.921 1.00 37.56 ? 427 ARG A CZ 1 ATOM 3366 N NH1 . ARG A 1 411 ? 32.211 -29.882 23.379 1.00 37.22 ? 427 ARG A NH1 1 ATOM 3367 N NH2 . ARG A 1 411 ? 31.529 -27.718 23.711 1.00 37.11 ? 427 ARG A NH2 1 ATOM 3368 N N . ILE A 1 412 ? 32.908 -29.817 16.229 1.00 34.30 ? 428 ILE A N 1 ATOM 3369 C CA . ILE A 1 412 ? 34.163 -29.197 15.810 1.00 33.82 ? 428 ILE A CA 1 ATOM 3370 C C . ILE A 1 412 ? 33.980 -28.398 14.515 1.00 33.60 ? 428 ILE A C 1 ATOM 3371 O O . ILE A 1 412 ? 34.485 -27.282 14.409 1.00 33.61 ? 428 ILE A O 1 ATOM 3372 C CB . ILE A 1 412 ? 35.316 -30.238 15.676 1.00 34.00 ? 428 ILE A CB 1 ATOM 3373 C CG1 . ILE A 1 412 ? 35.680 -30.836 17.048 1.00 33.78 ? 428 ILE A CG1 1 ATOM 3374 C CG2 . ILE A 1 412 ? 36.550 -29.618 15.009 1.00 33.31 ? 428 ILE A CG2 1 ATOM 3375 C CD1 . ILE A 1 412 ? 36.088 -29.811 18.118 1.00 34.34 ? 428 ILE A CD1 1 ATOM 3376 N N . ASN A 1 413 ? 33.258 -28.962 13.546 1.00 33.24 ? 429 ASN A N 1 ATOM 3377 C CA . ASN A 1 413 ? 32.905 -28.225 12.324 1.00 33.18 ? 429 ASN A CA 1 ATOM 3378 C C . ASN A 1 413 ? 32.212 -26.895 12.635 1.00 32.83 ? 429 ASN A C 1 ATOM 3379 O O . ASN A 1 413 ? 32.578 -25.857 12.092 1.00 32.36 ? 429 ASN A O 1 ATOM 3380 C CB . ASN A 1 413 ? 32.009 -29.065 11.411 1.00 33.20 ? 429 ASN A CB 1 ATOM 3381 C CG . ASN A 1 413 ? 32.795 -29.956 10.468 1.00 34.33 ? 429 ASN A CG 1 ATOM 3382 O OD1 . ASN A 1 413 ? 34.026 -29.935 10.444 1.00 34.88 ? 429 ASN A OD1 1 ATOM 3383 N ND2 . ASN A 1 413 ? 32.079 -30.745 9.679 1.00 33.59 ? 429 ASN A ND2 1 ATOM 3384 N N . GLN A 1 414 ? 31.224 -26.941 13.531 1.00 32.91 ? 430 GLN A N 1 ATOM 3385 C CA . GLN A 1 414 ? 30.443 -25.755 13.900 1.00 32.94 ? 430 GLN A CA 1 ATOM 3386 C C . GLN A 1 414 ? 31.288 -24.741 14.671 1.00 32.65 ? 430 GLN A C 1 ATOM 3387 O O . GLN A 1 414 ? 31.220 -23.535 14.408 1.00 32.43 ? 430 GLN A O 1 ATOM 3388 C CB . GLN A 1 414 ? 29.171 -26.158 14.668 1.00 33.10 ? 430 GLN A CB 1 ATOM 3389 C CG . GLN A 1 414 ? 28.349 -24.998 15.261 1.00 33.52 ? 430 GLN A CG 1 ATOM 3390 C CD . GLN A 1 414 ? 27.798 -24.017 14.227 1.00 35.14 ? 430 GLN A CD 1 ATOM 3391 O OE1 . GLN A 1 414 ? 27.605 -24.348 13.044 1.00 34.07 ? 430 GLN A OE1 1 ATOM 3392 N NE2 . GLN A 1 414 ? 27.529 -22.793 14.681 1.00 35.33 ? 430 GLN A NE2 1 ATOM 3393 N N . LEU A 1 415 ? 32.106 -25.233 15.599 1.00 32.72 ? 431 LEU A N 1 ATOM 3394 C CA . LEU A 1 415 ? 33.043 -24.372 16.315 1.00 32.51 ? 431 LEU A CA 1 ATOM 3395 C C . LEU A 1 415 ? 34.039 -23.694 15.365 1.00 32.41 ? 431 LEU A C 1 ATOM 3396 O O . LEU A 1 415 ? 34.326 -22.505 15.501 1.00 32.11 ? 431 LEU A O 1 ATOM 3397 C CB . LEU A 1 415 ? 33.782 -25.158 17.389 1.00 32.64 ? 431 LEU A CB 1 ATOM 3398 C CG . LEU A 1 415 ? 33.060 -25.318 18.729 1.00 33.01 ? 431 LEU A CG 1 ATOM 3399 C CD1 . LEU A 1 415 ? 33.759 -26.353 19.579 1.00 33.58 ? 431 LEU A CD1 1 ATOM 3400 C CD2 . LEU A 1 415 ? 32.978 -23.986 19.466 1.00 33.76 ? 431 LEU A CD2 1 ATOM 3401 N N . PHE A 1 416 ? 34.554 -24.455 14.404 1.00 32.14 ? 432 PHE A N 1 ATOM 3402 C CA . PHE A 1 416 ? 35.537 -23.935 13.458 1.00 32.10 ? 432 PHE A CA 1 ATOM 3403 C C . PHE A 1 416 ? 34.891 -22.883 12.563 1.00 31.85 ? 432 PHE A C 1 ATOM 3404 O O . PHE A 1 416 ? 35.476 -21.833 12.323 1.00 31.89 ? 432 PHE A O 1 ATOM 3405 C CB . PHE A 1 416 ? 36.138 -25.069 12.626 1.00 32.07 ? 432 PHE A CB 1 ATOM 3406 C CG . PHE A 1 416 ? 37.358 -24.673 11.842 1.00 32.21 ? 432 PHE A CG 1 ATOM 3407 C CD1 . PHE A 1 416 ? 38.591 -24.533 12.472 1.00 32.68 ? 432 PHE A CD1 1 ATOM 3408 C CD2 . PHE A 1 416 ? 37.275 -24.452 10.470 1.00 32.76 ? 432 PHE A CD2 1 ATOM 3409 C CE1 . PHE A 1 416 ? 39.725 -24.169 11.749 1.00 33.31 ? 432 PHE A CE1 1 ATOM 3410 C CE2 . PHE A 1 416 ? 38.407 -24.095 9.733 1.00 32.60 ? 432 PHE A CE2 1 ATOM 3411 C CZ . PHE A 1 416 ? 39.630 -23.949 10.374 1.00 33.46 ? 432 PHE A CZ 1 ATOM 3412 N N . LEU A 1 417 ? 33.678 -23.174 12.096 1.00 31.80 ? 433 LEU A N 1 ATOM 3413 C CA . LEU A 1 417 ? 32.883 -22.235 11.311 1.00 31.76 ? 433 LEU A CA 1 ATOM 3414 C C . LEU A 1 417 ? 32.667 -20.917 12.056 1.00 31.45 ? 433 LEU A C 1 ATOM 3415 O O . LEU A 1 417 ? 32.817 -19.842 11.476 1.00 30.99 ? 433 LEU A O 1 ATOM 3416 C CB . LEU A 1 417 ? 31.534 -22.867 10.920 1.00 31.97 ? 433 LEU A CB 1 ATOM 3417 C CG . LEU A 1 417 ? 30.481 -22.037 10.165 1.00 32.59 ? 433 LEU A CG 1 ATOM 3418 C CD1 . LEU A 1 417 ? 31.000 -21.509 8.808 1.00 32.67 ? 433 LEU A CD1 1 ATOM 3419 C CD2 . LEU A 1 417 ? 29.189 -22.836 9.974 1.00 31.98 ? 433 LEU A CD2 1 ATOM 3420 N N . THR A 1 418 ? 32.328 -20.999 13.343 1.00 30.98 ? 434 THR A N 1 ATOM 3421 C CA . THR A 1 418 ? 32.161 -19.794 14.150 1.00 30.82 ? 434 THR A CA 1 ATOM 3422 C C . THR A 1 418 ? 33.476 -19.013 14.251 1.00 30.72 ? 434 THR A C 1 ATOM 3423 O O . THR A 1 418 ? 33.487 -17.785 14.109 1.00 30.90 ? 434 THR A O 1 ATOM 3424 C CB . THR A 1 418 ? 31.593 -20.118 15.549 1.00 30.73 ? 434 THR A CB 1 ATOM 3425 O OG1 . THR A 1 418 ? 30.348 -20.809 15.400 1.00 31.03 ? 434 THR A OG1 1 ATOM 3426 C CG2 . THR A 1 418 ? 31.358 -18.842 16.356 1.00 30.52 ? 434 THR A CG2 1 ATOM 3427 N N . ALA A 1 419 ? 34.573 -19.736 14.472 1.00 30.64 ? 435 ALA A N 1 ATOM 3428 C CA . ALA A 1 419 ? 35.902 -19.140 14.616 1.00 30.73 ? 435 ALA A CA 1 ATOM 3429 C C . ALA A 1 419 ? 36.368 -18.424 13.348 1.00 30.97 ? 435 ALA A C 1 ATOM 3430 O O . ALA A 1 419 ? 37.041 -17.394 13.427 1.00 30.72 ? 435 ALA A O 1 ATOM 3431 C CB . ALA A 1 419 ? 36.907 -20.194 15.017 1.00 30.54 ? 435 ALA A CB 1 ATOM 3432 N N . LEU A 1 420 ? 36.016 -18.979 12.189 1.00 31.41 ? 436 LEU A N 1 ATOM 3433 C CA . LEU A 1 420 ? 36.321 -18.343 10.903 1.00 32.22 ? 436 LEU A CA 1 ATOM 3434 C C . LEU A 1 420 ? 35.704 -16.946 10.812 1.00 33.00 ? 436 LEU A C 1 ATOM 3435 O O . LEU A 1 420 ? 36.214 -16.095 10.086 1.00 33.37 ? 436 LEU A O 1 ATOM 3436 C CB . LEU A 1 420 ? 35.865 -19.215 9.730 1.00 31.68 ? 436 LEU A CB 1 ATOM 3437 C CG . LEU A 1 420 ? 36.569 -20.564 9.518 1.00 31.54 ? 436 LEU A CG 1 ATOM 3438 C CD1 . LEU A 1 420 ? 35.932 -21.326 8.357 1.00 32.08 ? 436 LEU A CD1 1 ATOM 3439 C CD2 . LEU A 1 420 ? 38.079 -20.398 9.289 1.00 31.22 ? 436 LEU A CD2 1 ATOM 3440 N N . ASP A 1 421 ? 34.606 -16.730 11.545 1.00 33.85 ? 437 ASP A N 1 ATOM 3441 C CA . ASP A 1 421 ? 34.002 -15.402 11.722 1.00 34.77 ? 437 ASP A CA 1 ATOM 3442 C C . ASP A 1 421 ? 34.662 -14.662 12.889 1.00 34.30 ? 437 ASP A C 1 ATOM 3443 O O . ASP A 1 421 ? 35.214 -13.584 12.705 1.00 35.13 ? 437 ASP A O 1 ATOM 3444 C CB . ASP A 1 421 ? 32.490 -15.499 12.025 1.00 35.52 ? 437 ASP A CB 1 ATOM 3445 C CG . ASP A 1 421 ? 31.626 -15.732 10.788 1.00 39.21 ? 437 ASP A CG 1 ATOM 3446 O OD1 . ASP A 1 421 ? 32.154 -15.745 9.645 1.00 43.08 ? 437 ASP A OD1 1 ATOM 3447 O OD2 . ASP A 1 421 ? 30.388 -15.909 10.970 1.00 42.16 ? 437 ASP A OD2 1 ATOM 3448 N N . LYS A 1 422 ? 34.608 -15.256 14.082 1.00 33.32 ? 438 LYS A N 1 ATOM 3449 C CA . LYS A 1 422 ? 34.846 -14.529 15.345 1.00 32.40 ? 438 LYS A CA 1 ATOM 3450 C C . LYS A 1 422 ? 36.305 -14.351 15.778 1.00 31.90 ? 438 LYS A C 1 ATOM 3451 O O . LYS A 1 422 ? 36.659 -13.314 16.345 1.00 32.01 ? 438 LYS A O 1 ATOM 3452 C CB . LYS A 1 422 ? 34.038 -15.161 16.494 1.00 32.46 ? 438 LYS A CB 1 ATOM 3453 C CG . LYS A 1 422 ? 32.515 -15.211 16.271 1.00 32.08 ? 438 LYS A CG 1 ATOM 3454 C CD . LYS A 1 422 ? 31.901 -13.819 16.130 1.00 31.24 ? 438 LYS A CD 1 ATOM 3455 C CE . LYS A 1 422 ? 30.390 -13.866 15.939 1.00 30.76 ? 438 LYS A CE 1 ATOM 3456 N NZ . LYS A 1 422 ? 29.836 -12.478 15.850 1.00 28.92 ? 438 LYS A NZ 1 ATOM 3457 N N . ILE A 1 423 ? 37.143 -15.356 15.542 1.00 30.87 ? 439 ILE A N 1 ATOM 3458 C CA . ILE A 1 423 ? 38.562 -15.250 15.899 1.00 30.08 ? 439 ILE A CA 1 ATOM 3459 C C . ILE A 1 423 ? 39.371 -14.568 14.792 1.00 29.61 ? 439 ILE A C 1 ATOM 3460 O O . ILE A 1 423 ? 40.169 -13.673 15.062 1.00 29.45 ? 439 ILE A O 1 ATOM 3461 C CB . ILE A 1 423 ? 39.186 -16.631 16.244 1.00 30.00 ? 439 ILE A CB 1 ATOM 3462 C CG1 . ILE A 1 423 ? 38.447 -17.297 17.422 1.00 30.65 ? 439 ILE A CG1 1 ATOM 3463 C CG2 . ILE A 1 423 ? 40.689 -16.492 16.531 1.00 29.98 ? 439 ILE A CG2 1 ATOM 3464 C CD1 . ILE A 1 423 ? 38.413 -16.477 18.719 1.00 31.25 ? 439 ILE A CD1 1 ATOM 3465 N N . VAL A 1 424 ? 39.154 -15.003 13.551 1.00 28.94 ? 440 VAL A N 1 ATOM 3466 C CA . VAL A 1 424 ? 39.817 -14.429 12.373 1.00 28.48 ? 440 VAL A CA 1 ATOM 3467 C C . VAL A 1 424 ? 39.692 -12.904 12.299 1.00 28.17 ? 440 VAL A C 1 ATOM 3468 O O . VAL A 1 424 ? 40.629 -12.204 11.902 1.00 28.13 ? 440 VAL A O 1 ATOM 3469 C CB . VAL A 1 424 ? 39.261 -15.076 11.086 1.00 28.53 ? 440 VAL A CB 1 ATOM 3470 C CG1 . VAL A 1 424 ? 39.590 -14.238 9.850 1.00 29.21 ? 440 VAL A CG1 1 ATOM 3471 C CG2 . VAL A 1 424 ? 39.792 -16.497 10.942 1.00 28.29 ? 440 VAL A CG2 1 ATOM 3472 N N . PHE A 1 425 ? 38.531 -12.400 12.706 1.00 27.96 ? 441 PHE A N 1 ATOM 3473 C CA . PHE A 1 425 ? 38.212 -10.979 12.655 1.00 27.47 ? 441 PHE A CA 1 ATOM 3474 C C . PHE A 1 425 ? 39.028 -10.121 13.630 1.00 27.66 ? 441 PHE A C 1 ATOM 3475 O O . PHE A 1 425 ? 39.253 -8.945 13.368 1.00 27.69 ? 441 PHE A O 1 ATOM 3476 C CB . PHE A 1 425 ? 36.714 -10.814 12.923 1.00 27.43 ? 441 PHE A CB 1 ATOM 3477 C CG . PHE A 1 425 ? 36.217 -9.393 12.864 1.00 27.08 ? 441 PHE A CG 1 ATOM 3478 C CD1 . PHE A 1 425 ? 35.924 -8.791 11.641 1.00 25.53 ? 441 PHE A CD1 1 ATOM 3479 C CD2 . PHE A 1 425 ? 35.997 -8.672 14.041 1.00 25.53 ? 441 PHE A CD2 1 ATOM 3480 C CE1 . PHE A 1 425 ? 35.441 -7.488 11.594 1.00 25.35 ? 441 PHE A CE1 1 ATOM 3481 C CE2 . PHE A 1 425 ? 35.510 -7.380 14.004 1.00 24.15 ? 441 PHE A CE2 1 ATOM 3482 C CZ . PHE A 1 425 ? 35.240 -6.780 12.785 1.00 26.89 ? 441 PHE A CZ 1 ATOM 3483 N N . LEU A 1 426 ? 39.461 -10.691 14.754 1.00 27.78 ? 442 LEU A N 1 ATOM 3484 C CA . LEU A 1 426 ? 40.135 -9.883 15.782 1.00 27.93 ? 442 LEU A CA 1 ATOM 3485 C C . LEU A 1 426 ? 41.409 -9.165 15.296 1.00 27.86 ? 442 LEU A C 1 ATOM 3486 O O . LEU A 1 426 ? 41.519 -7.947 15.454 1.00 28.20 ? 442 LEU A O 1 ATOM 3487 C CB . LEU A 1 426 ? 40.401 -10.691 17.060 1.00 28.15 ? 442 LEU A CB 1 ATOM 3488 C CG . LEU A 1 426 ? 39.199 -11.399 17.688 1.00 28.46 ? 442 LEU A CG 1 ATOM 3489 C CD1 . LEU A 1 426 ? 39.630 -12.186 18.919 1.00 29.19 ? 442 LEU A CD1 1 ATOM 3490 C CD2 . LEU A 1 426 ? 38.112 -10.409 18.044 1.00 28.55 ? 442 LEU A CD2 1 ATOM 3491 N N . PRO A 1 427 ? 42.372 -9.897 14.700 1.00 27.72 ? 443 PRO A N 1 ATOM 3492 C CA . PRO A 1 427 ? 43.497 -9.118 14.181 1.00 27.71 ? 443 PRO A CA 1 ATOM 3493 C C . PRO A 1 427 ? 43.074 -8.136 13.081 1.00 27.58 ? 443 PRO A C 1 ATOM 3494 O O . PRO A 1 427 ? 43.629 -7.041 13.003 1.00 27.39 ? 443 PRO A O 1 ATOM 3495 C CB . PRO A 1 427 ? 44.455 -10.183 13.625 1.00 27.74 ? 443 PRO A CB 1 ATOM 3496 C CG . PRO A 1 427 ? 43.638 -11.428 13.488 1.00 28.45 ? 443 PRO A CG 1 ATOM 3497 C CD . PRO A 1 427 ? 42.592 -11.348 14.555 1.00 27.63 ? 443 PRO A CD 1 ATOM 3498 N N . PHE A 1 428 ? 42.101 -8.514 12.251 1.00 27.52 ? 444 PHE A N 1 ATOM 3499 C CA . PHE A 1 428 ? 41.614 -7.592 11.214 1.00 27.55 ? 444 PHE A CA 1 ATOM 3500 C C . PHE A 1 428 ? 41.112 -6.285 11.822 1.00 27.19 ? 444 PHE A C 1 ATOM 3501 O O . PHE A 1 428 ? 41.594 -5.209 11.484 1.00 27.50 ? 444 PHE A O 1 ATOM 3502 C CB . PHE A 1 428 ? 40.500 -8.201 10.362 1.00 27.27 ? 444 PHE A CB 1 ATOM 3503 C CG . PHE A 1 428 ? 39.873 -7.211 9.422 1.00 27.12 ? 444 PHE A CG 1 ATOM 3504 C CD1 . PHE A 1 428 ? 40.444 -6.969 8.170 1.00 26.37 ? 444 PHE A CD1 1 ATOM 3505 C CD2 . PHE A 1 428 ? 38.732 -6.497 9.791 1.00 26.18 ? 444 PHE A CD2 1 ATOM 3506 C CE1 . PHE A 1 428 ? 39.879 -6.043 7.299 1.00 24.78 ? 444 PHE A CE1 1 ATOM 3507 C CE2 . PHE A 1 428 ? 38.154 -5.564 8.915 1.00 26.83 ? 444 PHE A CE2 1 ATOM 3508 C CZ . PHE A 1 428 ? 38.734 -5.346 7.665 1.00 25.00 ? 444 PHE A CZ 1 ATOM 3509 N N . ALA A 1 429 ? 40.136 -6.392 12.716 1.00 27.18 ? 445 ALA A N 1 ATOM 3510 C CA . ALA A 1 429 ? 39.585 -5.228 13.407 1.00 27.16 ? 445 ALA A CA 1 ATOM 3511 C C . ALA A 1 429 ? 40.665 -4.367 14.072 1.00 27.23 ? 445 ALA A C 1 ATOM 3512 O O . ALA A 1 429 ? 40.606 -3.137 14.013 1.00 27.50 ? 445 ALA A O 1 ATOM 3513 C CB . ALA A 1 429 ? 38.543 -5.660 14.422 1.00 26.71 ? 445 ALA A CB 1 ATOM 3514 N N . PHE A 1 430 ? 41.658 -5.001 14.685 1.00 27.51 ? 446 PHE A N 1 ATOM 3515 C CA . PHE A 1 430 ? 42.706 -4.237 15.378 1.00 27.99 ? 446 PHE A CA 1 ATOM 3516 C C . PHE A 1 430 ? 43.518 -3.397 14.387 1.00 27.94 ? 446 PHE A C 1 ATOM 3517 O O . PHE A 1 430 ? 43.823 -2.237 14.668 1.00 27.76 ? 446 PHE A O 1 ATOM 3518 C CB . PHE A 1 430 ? 43.626 -5.149 16.201 1.00 27.96 ? 446 PHE A CB 1 ATOM 3519 C CG . PHE A 1 430 ? 44.104 -4.536 17.510 1.00 28.68 ? 446 PHE A CG 1 ATOM 3520 C CD1 . PHE A 1 430 ? 43.882 -3.192 17.805 1.00 29.19 ? 446 PHE A CD1 1 ATOM 3521 C CD2 . PHE A 1 430 ? 44.791 -5.315 18.443 1.00 29.92 ? 446 PHE A CD2 1 ATOM 3522 C CE1 . PHE A 1 430 ? 44.314 -2.634 19.016 1.00 29.34 ? 446 PHE A CE1 1 ATOM 3523 C CE2 . PHE A 1 430 ? 45.241 -4.762 19.653 1.00 30.17 ? 446 PHE A CE2 1 ATOM 3524 C CZ . PHE A 1 430 ? 45.000 -3.420 19.935 1.00 29.89 ? 446 PHE A CZ 1 ATOM 3525 N N . THR A 1 431 ? 43.825 -3.967 13.217 1.00 27.97 ? 447 THR A N 1 ATOM 3526 C CA . THR A 1 431 ? 44.642 -3.261 12.221 1.00 28.01 ? 447 THR A CA 1 ATOM 3527 C C . THR A 1 431 ? 43.968 -2.049 11.586 1.00 28.09 ? 447 THR A C 1 ATOM 3528 O O . THR A 1 431 ? 44.645 -1.084 11.235 1.00 28.38 ? 447 THR A O 1 ATOM 3529 C CB . THR A 1 431 ? 45.171 -4.192 11.090 1.00 28.00 ? 447 THR A CB 1 ATOM 3530 O OG1 . THR A 1 431 ? 44.073 -4.812 10.404 1.00 28.19 ? 447 THR A OG1 1 ATOM 3531 C CG2 . THR A 1 431 ? 46.086 -5.250 11.667 1.00 27.50 ? 447 THR A CG2 1 ATOM 3532 N N . MET A 1 432 ? 42.648 -2.100 11.421 1.00 28.40 ? 448 MET A N 1 ATOM 3533 C CA . MET A 1 432 ? 41.922 -0.988 10.803 1.00 28.39 ? 448 MET A CA 1 ATOM 3534 C C . MET A 1 432 ? 42.172 0.297 11.587 1.00 28.54 ? 448 MET A C 1 ATOM 3535 O O . MET A 1 432 ? 42.439 1.345 11.006 1.00 28.53 ? 448 MET A O 1 ATOM 3536 C CB . MET A 1 432 ? 40.416 -1.273 10.705 1.00 28.28 ? 448 MET A CB 1 ATOM 3537 C CG . MET A 1 432 ? 40.024 -2.411 9.764 1.00 28.46 ? 448 MET A CG 1 ATOM 3538 S SD . MET A 1 432 ? 40.507 -2.145 8.036 1.00 29.22 ? 448 MET A SD 1 ATOM 3539 C CE . MET A 1 432 ? 41.974 -3.161 7.898 1.00 27.67 ? 448 MET A CE 1 ATOM 3540 N N . ASP A 1 433 ? 42.110 0.215 12.912 1.00 28.41 ? 449 ASP A N 1 ATOM 3541 C CA . ASP A 1 433 ? 42.344 1.406 13.715 1.00 28.39 ? 449 ASP A CA 1 ATOM 3542 C C . ASP A 1 433 ? 43.809 1.656 14.061 1.00 28.13 ? 449 ASP A C 1 ATOM 3543 O O . ASP A 1 433 ? 44.222 2.803 14.149 1.00 28.41 ? 449 ASP A O 1 ATOM 3544 C CB . ASP A 1 433 ? 41.394 1.483 14.922 1.00 28.50 ? 449 ASP A CB 1 ATOM 3545 C CG . ASP A 1 433 ? 40.046 2.084 14.546 1.00 29.43 ? 449 ASP A CG 1 ATOM 3546 O OD1 . ASP A 1 433 ? 39.801 2.277 13.328 1.00 30.17 ? 449 ASP A OD1 1 ATOM 3547 O OD2 . ASP A 1 433 ? 39.239 2.390 15.450 1.00 28.79 ? 449 ASP A OD2 1 ATOM 3548 N N . LYS A 1 434 ? 44.610 0.603 14.207 1.00 28.02 ? 450 LYS A N 1 ATOM 3549 C CA . LYS A 1 434 ? 46.056 0.811 14.342 1.00 28.04 ? 450 LYS A CA 1 ATOM 3550 C C . LYS A 1 434 ? 46.599 1.591 13.140 1.00 27.97 ? 450 LYS A C 1 ATOM 3551 O O . LYS A 1 434 ? 47.437 2.491 13.294 1.00 27.74 ? 450 LYS A O 1 ATOM 3552 C CB . LYS A 1 434 ? 46.805 -0.510 14.500 1.00 28.16 ? 450 LYS A CB 1 ATOM 3553 C CG . LYS A 1 434 ? 46.713 -1.117 15.900 1.00 28.20 ? 450 LYS A CG 1 ATOM 3554 C CD . LYS A 1 434 ? 47.343 -2.495 15.926 1.00 28.32 ? 450 LYS A CD 1 ATOM 3555 C CE . LYS A 1 434 ? 47.538 -2.996 17.360 1.00 29.37 ? 450 LYS A CE 1 ATOM 3556 N NZ . LYS A 1 434 ? 48.663 -2.319 18.048 1.00 28.34 ? 450 LYS A NZ 1 ATOM 3557 N N . TYR A 1 435 ? 46.117 1.250 11.946 1.00 27.60 ? 451 TYR A N 1 ATOM 3558 C CA . TYR A 1 435 ? 46.536 1.976 10.745 1.00 27.49 ? 451 TYR A CA 1 ATOM 3559 C C . TYR A 1 435 ? 46.134 3.437 10.822 1.00 27.36 ? 451 TYR A C 1 ATOM 3560 O O . TYR A 1 435 ? 46.985 4.326 10.725 1.00 27.61 ? 451 TYR A O 1 ATOM 3561 C CB . TYR A 1 435 ? 45.965 1.337 9.480 1.00 27.49 ? 451 TYR A CB 1 ATOM 3562 C CG . TYR A 1 435 ? 46.350 2.072 8.210 1.00 28.26 ? 451 TYR A CG 1 ATOM 3563 C CD1 . TYR A 1 435 ? 47.683 2.147 7.798 1.00 28.68 ? 451 TYR A CD1 1 ATOM 3564 C CD2 . TYR A 1 435 ? 45.380 2.687 7.421 1.00 29.53 ? 451 TYR A CD2 1 ATOM 3565 C CE1 . TYR A 1 435 ? 48.042 2.821 6.626 1.00 29.95 ? 451 TYR A CE1 1 ATOM 3566 C CE2 . TYR A 1 435 ? 45.727 3.362 6.244 1.00 30.25 ? 451 TYR A CE2 1 ATOM 3567 C CZ . TYR A 1 435 ? 47.055 3.422 5.855 1.00 30.82 ? 451 TYR A CZ 1 ATOM 3568 O OH . TYR A 1 435 ? 47.389 4.087 4.692 1.00 33.42 ? 451 TYR A OH 1 ATOM 3569 N N . ARG A 1 436 ? 44.842 3.690 11.008 1.00 27.43 ? 452 ARG A N 1 ATOM 3570 C CA . ARG A 1 436 ? 44.353 5.064 11.045 1.00 27.79 ? 452 ARG A CA 1 ATOM 3571 C C . ARG A 1 436 ? 44.936 5.861 12.208 1.00 27.85 ? 452 ARG A C 1 ATOM 3572 O O . ARG A 1 436 ? 45.273 7.035 12.040 1.00 27.72 ? 452 ARG A O 1 ATOM 3573 C CB . ARG A 1 436 ? 42.824 5.109 11.031 1.00 27.77 ? 452 ARG A CB 1 ATOM 3574 C CG . ARG A 1 436 ? 42.238 4.687 9.672 1.00 27.94 ? 452 ARG A CG 1 ATOM 3575 C CD . ARG A 1 436 ? 40.742 4.875 9.609 1.00 27.36 ? 452 ARG A CD 1 ATOM 3576 N NE . ARG A 1 436 ? 40.019 3.895 10.411 1.00 27.95 ? 452 ARG A NE 1 ATOM 3577 C CZ . ARG A 1 436 ? 38.693 3.800 10.458 1.00 28.35 ? 452 ARG A CZ 1 ATOM 3578 N NH1 . ARG A 1 436 ? 37.934 4.621 9.740 1.00 27.97 ? 452 ARG A NH1 1 ATOM 3579 N NH2 . ARG A 1 436 ? 38.121 2.881 11.225 1.00 28.57 ? 452 ARG A NH2 1 ATOM 3580 N N . TRP A 1 437 ? 45.081 5.222 13.371 1.00 27.92 ? 453 TRP A N 1 ATOM 3581 C CA . TRP A 1 437 ? 45.733 5.878 14.508 1.00 28.49 ? 453 TRP A CA 1 ATOM 3582 C C . TRP A 1 437 ? 47.135 6.360 14.143 1.00 28.67 ? 453 TRP A C 1 ATOM 3583 O O . TRP A 1 437 ? 47.509 7.480 14.467 1.00 28.75 ? 453 TRP A O 1 ATOM 3584 C CB . TRP A 1 437 ? 45.862 4.942 15.712 1.00 28.35 ? 453 TRP A CB 1 ATOM 3585 C CG . TRP A 1 437 ? 44.590 4.564 16.403 1.00 28.73 ? 453 TRP A CG 1 ATOM 3586 C CD1 . TRP A 1 437 ? 43.367 5.163 16.288 1.00 28.82 ? 453 TRP A CD1 1 ATOM 3587 C CD2 . TRP A 1 437 ? 44.434 3.512 17.361 1.00 29.26 ? 453 TRP A CD2 1 ATOM 3588 N NE1 . TRP A 1 437 ? 42.454 4.537 17.108 1.00 29.52 ? 453 TRP A NE1 1 ATOM 3589 C CE2 . TRP A 1 437 ? 43.087 3.523 17.781 1.00 29.52 ? 453 TRP A CE2 1 ATOM 3590 C CE3 . TRP A 1 437 ? 45.306 2.557 17.905 1.00 30.01 ? 453 TRP A CE3 1 ATOM 3591 C CZ2 . TRP A 1 437 ? 42.587 2.609 18.713 1.00 28.78 ? 453 TRP A CZ2 1 ATOM 3592 C CZ3 . TRP A 1 437 ? 44.805 1.645 18.832 1.00 29.27 ? 453 TRP A CZ3 1 ATOM 3593 C CH2 . TRP A 1 437 ? 43.457 1.678 19.218 1.00 29.32 ? 453 TRP A CH2 1 ATOM 3594 N N . SER A 1 438 ? 47.910 5.504 13.483 1.00 29.34 ? 454 SER A N 1 ATOM 3595 C CA . SER A 1 438 ? 49.293 5.846 13.148 1.00 29.94 ? 454 SER A CA 1 ATOM 3596 C C . SER A 1 438 ? 49.358 7.029 12.178 1.00 30.41 ? 454 SER A C 1 ATOM 3597 O O . SER A 1 438 ? 50.286 7.839 12.248 1.00 30.23 ? 454 SER A O 1 ATOM 3598 C CB . SER A 1 438 ? 50.058 4.632 12.608 1.00 30.08 ? 454 SER A CB 1 ATOM 3599 O OG . SER A 1 438 ? 49.656 4.292 11.289 1.00 29.71 ? 454 SER A OG 1 ATOM 3600 N N . LEU A 1 439 ? 48.367 7.134 11.291 1.00 30.76 ? 455 LEU A N 1 ATOM 3601 C CA . LEU A 1 439 ? 48.280 8.279 10.379 1.00 31.07 ? 455 LEU A CA 1 ATOM 3602 C C . LEU A 1 439 ? 47.847 9.534 11.131 1.00 31.17 ? 455 LEU A C 1 ATOM 3603 O O . LEU A 1 439 ? 48.481 10.585 11.008 1.00 31.47 ? 455 LEU A O 1 ATOM 3604 C CB . LEU A 1 439 ? 47.320 8.002 9.216 1.00 30.97 ? 455 LEU A CB 1 ATOM 3605 C CG . LEU A 1 439 ? 47.533 6.791 8.302 1.00 31.60 ? 455 LEU A CG 1 ATOM 3606 C CD1 . LEU A 1 439 ? 46.586 6.893 7.106 1.00 31.64 ? 455 LEU A CD1 1 ATOM 3607 C CD2 . LEU A 1 439 ? 48.972 6.667 7.833 1.00 31.94 ? 455 LEU A CD2 1 ATOM 3608 N N . PHE A 1 440 ? 46.777 9.417 11.918 1.00 31.45 ? 456 PHE A N 1 ATOM 3609 C CA . PHE A 1 440 ? 46.286 10.521 12.758 1.00 31.67 ? 456 PHE A CA 1 ATOM 3610 C C . PHE A 1 440 ? 47.383 11.112 13.650 1.00 31.71 ? 456 PHE A C 1 ATOM 3611 O O . PHE A 1 440 ? 47.477 12.334 13.815 1.00 31.36 ? 456 PHE A O 1 ATOM 3612 C CB . PHE A 1 440 ? 45.120 10.059 13.646 1.00 31.71 ? 456 PHE A CB 1 ATOM 3613 C CG . PHE A 1 440 ? 43.844 9.745 12.896 1.00 32.91 ? 456 PHE A CG 1 ATOM 3614 C CD1 . PHE A 1 440 ? 43.620 10.229 11.607 1.00 32.76 ? 456 PHE A CD1 1 ATOM 3615 C CD2 . PHE A 1 440 ? 42.865 8.956 13.490 1.00 33.25 ? 456 PHE A CD2 1 ATOM 3616 C CE1 . PHE A 1 440 ? 42.442 9.931 10.925 1.00 33.59 ? 456 PHE A CE1 1 ATOM 3617 C CE2 . PHE A 1 440 ? 41.680 8.657 12.817 1.00 33.39 ? 456 PHE A CE2 1 ATOM 3618 C CZ . PHE A 1 440 ? 41.470 9.145 11.531 1.00 33.67 ? 456 PHE A CZ 1 ATOM 3619 N N . ARG A 1 441 ? 48.202 10.229 14.220 1.00 31.85 ? 457 ARG A N 1 ATOM 3620 C CA . ARG A 1 441 ? 49.273 10.609 15.151 1.00 32.14 ? 457 ARG A CA 1 ATOM 3621 C C . ARG A 1 441 ? 50.535 11.140 14.459 1.00 32.36 ? 457 ARG A C 1 ATOM 3622 O O . ARG A 1 441 ? 51.464 11.589 15.123 1.00 31.99 ? 457 ARG A O 1 ATOM 3623 C CB . ARG A 1 441 ? 49.625 9.417 16.052 1.00 31.88 ? 457 ARG A CB 1 ATOM 3624 C CG . ARG A 1 441 ? 48.588 9.150 17.130 1.00 31.89 ? 457 ARG A CG 1 ATOM 3625 C CD . ARG A 1 441 ? 48.685 7.748 17.717 1.00 31.53 ? 457 ARG A CD 1 ATOM 3626 N NE . ARG A 1 441 ? 47.875 7.632 18.936 1.00 31.14 ? 457 ARG A NE 1 ATOM 3627 C CZ . ARG A 1 441 ? 47.531 6.483 19.519 1.00 31.12 ? 457 ARG A CZ 1 ATOM 3628 N NH1 . ARG A 1 441 ? 47.915 5.316 19.009 1.00 30.77 ? 457 ARG A NH1 1 ATOM 3629 N NH2 . ARG A 1 441 ? 46.791 6.497 20.621 1.00 31.78 ? 457 ARG A NH2 1 ATOM 3630 N N . GLY A 1 442 ? 50.560 11.087 13.127 1.00 32.74 ? 458 GLY A N 1 ATOM 3631 C CA . GLY A 1 442 ? 51.704 11.564 12.350 1.00 33.32 ? 458 GLY A CA 1 ATOM 3632 C C . GLY A 1 442 ? 52.916 10.653 12.441 1.00 33.86 ? 458 GLY A C 1 ATOM 3633 O O . GLY A 1 442 ? 54.051 11.116 12.354 1.00 33.97 ? 458 GLY A O 1 ATOM 3634 N N . GLU A 1 443 ? 52.671 9.356 12.609 1.00 34.42 ? 459 GLU A N 1 ATOM 3635 C CA . GLU A 1 443 ? 53.741 8.370 12.806 1.00 35.32 ? 459 GLU A CA 1 ATOM 3636 C C . GLU A 1 443 ? 54.260 7.747 11.502 1.00 35.99 ? 459 GLU A C 1 ATOM 3637 O O . GLU A 1 443 ? 55.316 7.124 11.495 1.00 36.16 ? 459 GLU A O 1 ATOM 3638 C CB . GLU A 1 443 ? 53.287 7.281 13.786 1.00 35.14 ? 459 GLU A CB 1 ATOM 3639 C CG . GLU A 1 443 ? 53.033 7.806 15.204 1.00 35.38 ? 459 GLU A CG 1 ATOM 3640 C CD . GLU A 1 443 ? 52.356 6.793 16.116 1.00 36.06 ? 459 GLU A CD 1 ATOM 3641 O OE1 . GLU A 1 443 ? 51.782 5.805 15.612 1.00 36.29 ? 459 GLU A OE1 1 ATOM 3642 O OE2 . GLU A 1 443 ? 52.390 6.992 17.348 1.00 36.06 ? 459 GLU A OE2 1 ATOM 3643 N N . VAL A 1 444 ? 53.523 7.924 10.408 1.00 36.77 ? 460 VAL A N 1 ATOM 3644 C CA . VAL A 1 444 ? 53.938 7.415 9.100 1.00 37.79 ? 460 VAL A CA 1 ATOM 3645 C C . VAL A 1 444 ? 54.072 8.576 8.118 1.00 38.75 ? 460 VAL A C 1 ATOM 3646 O O . VAL A 1 444 ? 53.144 9.369 7.966 1.00 38.94 ? 460 VAL A O 1 ATOM 3647 C CB . VAL A 1 444 ? 52.928 6.368 8.533 1.00 37.64 ? 460 VAL A CB 1 ATOM 3648 C CG1 . VAL A 1 444 ? 53.435 5.768 7.216 1.00 37.19 ? 460 VAL A CG1 1 ATOM 3649 C CG2 . VAL A 1 444 ? 52.645 5.256 9.548 1.00 37.89 ? 460 VAL A CG2 1 ATOM 3650 N N . ASP A 1 445 ? 55.225 8.679 7.459 1.00 40.10 ? 461 ASP A N 1 ATOM 3651 C CA . ASP A 1 445 ? 55.416 9.677 6.399 1.00 41.39 ? 461 ASP A CA 1 ATOM 3652 C C . ASP A 1 445 ? 54.491 9.353 5.231 1.00 41.30 ? 461 ASP A C 1 ATOM 3653 O O . ASP A 1 445 ? 54.252 8.179 4.944 1.00 41.13 ? 461 ASP A O 1 ATOM 3654 C CB . ASP A 1 445 ? 56.875 9.701 5.919 1.00 42.08 ? 461 ASP A CB 1 ATOM 3655 C CG . ASP A 1 445 ? 57.860 10.112 7.018 1.00 44.66 ? 461 ASP A CG 1 ATOM 3656 O OD1 . ASP A 1 445 ? 57.468 10.857 7.948 1.00 47.00 ? 461 ASP A OD1 1 ATOM 3657 O OD2 . ASP A 1 445 ? 59.041 9.691 6.945 1.00 47.51 ? 461 ASP A OD2 1 ATOM 3658 N N . LYS A 1 446 ? 53.988 10.395 4.563 1.00 41.50 ? 462 LYS A N 1 ATOM 3659 C CA . LYS A 1 446 ? 53.030 10.248 3.452 1.00 41.66 ? 462 LYS A CA 1 ATOM 3660 C C . LYS A 1 446 ? 53.523 9.326 2.341 1.00 40.97 ? 462 LYS A C 1 ATOM 3661 O O . LYS A 1 446 ? 52.725 8.644 1.695 1.00 40.95 ? 462 LYS A O 1 ATOM 3662 C CB . LYS A 1 446 ? 52.638 11.611 2.869 1.00 42.23 ? 462 LYS A CB 1 ATOM 3663 C CG . LYS A 1 446 ? 51.482 12.296 3.603 1.00 44.01 ? 462 LYS A CG 1 ATOM 3664 C CD . LYS A 1 446 ? 50.958 13.519 2.848 1.00 47.12 ? 462 LYS A CD 1 ATOM 3665 C CE . LYS A 1 446 ? 51.850 14.741 3.051 1.00 48.88 ? 462 LYS A CE 1 ATOM 3666 N NZ . LYS A 1 446 ? 51.387 15.907 2.233 1.00 50.56 ? 462 LYS A NZ 1 ATOM 3667 N N . ALA A 1 447 ? 54.837 9.301 2.145 1.00 40.39 ? 463 ALA A N 1 ATOM 3668 C CA . ALA A 1 447 ? 55.469 8.447 1.141 1.00 39.89 ? 463 ALA A CA 1 ATOM 3669 C C . ALA A 1 447 ? 55.375 6.952 1.467 1.00 39.34 ? 463 ALA A C 1 ATOM 3670 O O . ALA A 1 447 ? 55.641 6.116 0.604 1.00 39.07 ? 463 ALA A O 1 ATOM 3671 C CB . ALA A 1 447 ? 56.928 8.856 0.953 1.00 40.06 ? 463 ALA A CB 1 ATOM 3672 N N . ASN A 1 448 ? 55.003 6.623 2.706 1.00 38.55 ? 464 ASN A N 1 ATOM 3673 C CA . ASN A 1 448 ? 54.969 5.230 3.167 1.00 37.82 ? 464 ASN A CA 1 ATOM 3674 C C . ASN A 1 448 ? 53.573 4.742 3.560 1.00 37.00 ? 464 ASN A C 1 ATOM 3675 O O . ASN A 1 448 ? 53.434 3.667 4.142 1.00 36.60 ? 464 ASN A O 1 ATOM 3676 C CB . ASN A 1 448 ? 55.926 5.030 4.354 1.00 38.14 ? 464 ASN A CB 1 ATOM 3677 C CG . ASN A 1 448 ? 57.373 5.378 4.020 1.00 39.09 ? 464 ASN A CG 1 ATOM 3678 O OD1 . ASN A 1 448 ? 58.025 6.129 4.750 1.00 40.95 ? 464 ASN A OD1 1 ATOM 3679 N ND2 . ASN A 1 448 ? 57.879 4.832 2.923 1.00 39.10 ? 464 ASN A ND2 1 ATOM 3680 N N . TRP A 1 449 ? 52.551 5.528 3.224 1.00 36.14 ? 465 TRP A N 1 ATOM 3681 C CA . TRP A 1 449 ? 51.177 5.293 3.684 1.00 35.35 ? 465 TRP A CA 1 ATOM 3682 C C . TRP A 1 449 ? 50.540 3.978 3.252 1.00 34.91 ? 465 TRP A C 1 ATOM 3683 O O . TRP A 1 449 ? 49.881 3.322 4.062 1.00 34.85 ? 465 TRP A O 1 ATOM 3684 C CB . TRP A 1 449 ? 50.278 6.467 3.298 1.00 35.39 ? 465 TRP A CB 1 ATOM 3685 C CG . TRP A 1 449 ? 50.280 7.579 4.308 1.00 35.27 ? 465 TRP A CG 1 ATOM 3686 C CD1 . TRP A 1 449 ? 51.243 7.842 5.242 1.00 34.79 ? 465 TRP A CD1 1 ATOM 3687 C CD2 . TRP A 1 449 ? 49.286 8.594 4.461 1.00 35.15 ? 465 TRP A CD2 1 ATOM 3688 N NE1 . TRP A 1 449 ? 50.904 8.954 5.976 1.00 34.84 ? 465 TRP A NE1 1 ATOM 3689 C CE2 . TRP A 1 449 ? 49.706 9.435 5.520 1.00 35.11 ? 465 TRP A CE2 1 ATOM 3690 C CE3 . TRP A 1 449 ? 48.075 8.873 3.810 1.00 35.20 ? 465 TRP A CE3 1 ATOM 3691 C CZ2 . TRP A 1 449 ? 48.956 10.532 5.950 1.00 35.30 ? 465 TRP A CZ2 1 ATOM 3692 C CZ3 . TRP A 1 449 ? 47.328 9.964 4.236 1.00 35.08 ? 465 TRP A CZ3 1 ATOM 3693 C CH2 . TRP A 1 449 ? 47.775 10.783 5.297 1.00 35.53 ? 465 TRP A CH2 1 ATOM 3694 N N . ASN A 1 450 ? 50.731 3.584 1.996 1.00 34.13 ? 466 ASN A N 1 ATOM 3695 C CA . ASN A 1 450 ? 50.124 2.343 1.521 1.00 33.65 ? 466 ASN A CA 1 ATOM 3696 C C . ASN A 1 450 ? 50.775 1.089 2.068 1.00 33.43 ? 466 ASN A C 1 ATOM 3697 O O . ASN A 1 450 ? 50.080 0.179 2.517 1.00 33.15 ? 466 ASN A O 1 ATOM 3698 C CB . ASN A 1 450 ? 50.061 2.246 -0.008 1.00 33.36 ? 466 ASN A CB 1 ATOM 3699 C CG . ASN A 1 450 ? 49.009 1.245 -0.467 1.00 32.95 ? 466 ASN A CG 1 ATOM 3700 O OD1 . ASN A 1 450 ? 47.878 1.269 0.014 1.00 31.57 ? 466 ASN A OD1 1 ATOM 3701 N ND2 . ASN A 1 450 ? 49.379 0.355 -1.383 1.00 32.63 ? 466 ASN A ND2 1 ATOM 3702 N N . CYS A 1 451 ? 52.102 1.028 2.014 1.00 33.32 ? 467 CYS A N 1 ATOM 3703 C CA . CYS A 1 451 ? 52.795 -0.154 2.495 1.00 33.60 ? 467 CYS A CA 1 ATOM 3704 C C . CYS A 1 451 ? 52.727 -0.261 4.026 1.00 32.57 ? 467 CYS A C 1 ATOM 3705 O O . CYS A 1 451 ? 52.822 -1.353 4.563 1.00 32.23 ? 467 CYS A O 1 ATOM 3706 C CB . CYS A 1 451 ? 54.224 -0.233 1.956 1.00 34.16 ? 467 CYS A CB 1 ATOM 3707 S SG . CYS A 1 451 ? 54.326 -0.562 0.131 1.00 38.64 ? 467 CYS A SG 1 ATOM 3708 N N . ALA A 1 452 ? 52.519 0.864 4.711 1.00 31.69 ? 468 ALA A N 1 ATOM 3709 C CA . ALA A 1 452 ? 52.232 0.836 6.158 1.00 31.24 ? 468 ALA A CA 1 ATOM 3710 C C . ALA A 1 452 ? 50.914 0.096 6.450 1.00 30.80 ? 468 ALA A C 1 ATOM 3711 O O . ALA A 1 452 ? 50.787 -0.563 7.482 1.00 30.76 ? 468 ALA A O 1 ATOM 3712 C CB . ALA A 1 452 ? 52.205 2.238 6.735 1.00 30.51 ? 468 ALA A CB 1 ATOM 3713 N N . PHE A 1 453 ? 49.953 0.193 5.525 1.00 30.22 ? 469 PHE A N 1 ATOM 3714 C CA . PHE A 1 453 ? 48.687 -0.544 5.624 1.00 29.93 ? 469 PHE A CA 1 ATOM 3715 C C . PHE A 1 453 ? 48.927 -2.042 5.479 1.00 29.96 ? 469 PHE A C 1 ATOM 3716 O O . PHE A 1 453 ? 48.555 -2.829 6.360 1.00 29.34 ? 469 PHE A O 1 ATOM 3717 C CB . PHE A 1 453 ? 47.665 -0.043 4.584 1.00 29.88 ? 469 PHE A CB 1 ATOM 3718 C CG . PHE A 1 453 ? 46.341 -0.767 4.623 1.00 30.56 ? 469 PHE A CG 1 ATOM 3719 C CD1 . PHE A 1 453 ? 45.406 -0.498 5.627 1.00 30.66 ? 469 PHE A CD1 1 ATOM 3720 C CD2 . PHE A 1 453 ? 46.023 -1.714 3.653 1.00 30.71 ? 469 PHE A CD2 1 ATOM 3721 C CE1 . PHE A 1 453 ? 44.185 -1.164 5.666 1.00 30.09 ? 469 PHE A CE1 1 ATOM 3722 C CE2 . PHE A 1 453 ? 44.801 -2.385 3.683 1.00 30.44 ? 469 PHE A CE2 1 ATOM 3723 C CZ . PHE A 1 453 ? 43.880 -2.110 4.691 1.00 30.47 ? 469 PHE A CZ 1 ATOM 3724 N N . TRP A 1 454 ? 49.561 -2.432 4.371 1.00 29.55 ? 470 TRP A N 1 ATOM 3725 C CA . TRP A 1 454 ? 49.835 -3.840 4.112 1.00 29.75 ? 470 TRP A CA 1 ATOM 3726 C C . TRP A 1 454 ? 50.799 -4.482 5.112 1.00 29.88 ? 470 TRP A C 1 ATOM 3727 O O . TRP A 1 454 ? 50.661 -5.669 5.416 1.00 29.75 ? 470 TRP A O 1 ATOM 3728 C CB . TRP A 1 454 ? 50.262 -4.066 2.652 1.00 29.67 ? 470 TRP A CB 1 ATOM 3729 C CG . TRP A 1 454 ? 49.121 -3.771 1.713 1.00 29.56 ? 470 TRP A CG 1 ATOM 3730 C CD1 . TRP A 1 454 ? 49.083 -2.815 0.735 1.00 29.23 ? 470 TRP A CD1 1 ATOM 3731 C CD2 . TRP A 1 454 ? 47.830 -4.398 1.710 1.00 29.06 ? 470 TRP A CD2 1 ATOM 3732 N NE1 . TRP A 1 454 ? 47.857 -2.827 0.108 1.00 28.54 ? 470 TRP A NE1 1 ATOM 3733 C CE2 . TRP A 1 454 ? 47.072 -3.790 0.682 1.00 28.72 ? 470 TRP A CE2 1 ATOM 3734 C CE3 . TRP A 1 454 ? 47.245 -5.426 2.465 1.00 29.41 ? 470 TRP A CE3 1 ATOM 3735 C CZ2 . TRP A 1 454 ? 45.759 -4.176 0.389 1.00 28.84 ? 470 TRP A CZ2 1 ATOM 3736 C CZ3 . TRP A 1 454 ? 45.935 -5.803 2.179 1.00 29.00 ? 470 TRP A CZ3 1 ATOM 3737 C CH2 . TRP A 1 454 ? 45.208 -5.178 1.145 1.00 29.07 ? 470 TRP A CH2 1 ATOM 3738 N N . LYS A 1 455 ? 51.740 -3.696 5.640 1.00 30.11 ? 471 LYS A N 1 ATOM 3739 C CA . LYS A 1 455 ? 52.627 -4.166 6.712 1.00 30.71 ? 471 LYS A CA 1 ATOM 3740 C C . LYS A 1 455 ? 51.846 -4.637 7.944 1.00 30.28 ? 471 LYS A C 1 ATOM 3741 O O . LYS A 1 455 ? 52.109 -5.715 8.470 1.00 30.40 ? 471 LYS A O 1 ATOM 3742 C CB . LYS A 1 455 ? 53.643 -3.093 7.113 1.00 31.02 ? 471 LYS A CB 1 ATOM 3743 C CG . LYS A 1 455 ? 54.925 -3.089 6.275 1.00 33.86 ? 471 LYS A CG 1 ATOM 3744 C CD . LYS A 1 455 ? 55.938 -2.059 6.810 1.00 37.01 ? 471 LYS A CD 1 ATOM 3745 C CE . LYS A 1 455 ? 57.295 -2.200 6.128 1.00 39.47 ? 471 LYS A CE 1 ATOM 3746 N NZ . LYS A 1 455 ? 57.207 -1.877 4.665 1.00 41.01 ? 471 LYS A NZ 1 ATOM 3747 N N . LEU A 1 456 ? 50.880 -3.834 8.381 1.00 30.22 ? 472 LEU A N 1 ATOM 3748 C CA . LEU A 1 456 ? 50.027 -4.189 9.520 1.00 30.07 ? 472 LEU A CA 1 ATOM 3749 C C . LEU A 1 456 ? 49.191 -5.436 9.262 1.00 29.87 ? 472 LEU A C 1 ATOM 3750 O O . LEU A 1 456 ? 49.105 -6.326 10.120 1.00 29.31 ? 472 LEU A O 1 ATOM 3751 C CB . LEU A 1 456 ? 49.118 -3.016 9.895 1.00 30.16 ? 472 LEU A CB 1 ATOM 3752 C CG . LEU A 1 456 ? 49.760 -1.878 10.693 1.00 30.15 ? 472 LEU A CG 1 ATOM 3753 C CD1 . LEU A 1 456 ? 48.797 -0.720 10.755 1.00 29.26 ? 472 LEU A CD1 1 ATOM 3754 C CD2 . LEU A 1 456 ? 50.164 -2.311 12.113 1.00 30.38 ? 472 LEU A CD2 1 ATOM 3755 N N . ARG A 1 457 ? 48.586 -5.496 8.075 1.00 29.76 ? 473 ARG A N 1 ATOM 3756 C CA . ARG A 1 457 ? 47.785 -6.646 7.654 1.00 30.01 ? 473 ARG A CA 1 ATOM 3757 C C . ARG A 1 457 ? 48.615 -7.938 7.644 1.00 30.09 ? 473 ARG A C 1 ATOM 3758 O O . ARG A 1 457 ? 48.122 -9.010 8.012 1.00 30.05 ? 473 ARG A O 1 ATOM 3759 C CB . ARG A 1 457 ? 47.148 -6.392 6.275 1.00 29.97 ? 473 ARG A CB 1 ATOM 3760 C CG . ARG A 1 457 ? 46.291 -5.116 6.167 1.00 30.15 ? 473 ARG A CG 1 ATOM 3761 C CD . ARG A 1 457 ? 45.011 -5.156 7.028 1.00 30.39 ? 473 ARG A CD 1 ATOM 3762 N NE . ARG A 1 457 ? 44.199 -6.328 6.716 1.00 29.99 ? 473 ARG A NE 1 ATOM 3763 C CZ . ARG A 1 457 ? 44.011 -7.360 7.531 1.00 30.76 ? 473 ARG A CZ 1 ATOM 3764 N NH1 . ARG A 1 457 ? 44.539 -7.365 8.758 1.00 29.86 ? 473 ARG A NH1 1 ATOM 3765 N NH2 . ARG A 1 457 ? 43.280 -8.387 7.118 1.00 30.79 ? 473 ARG A NH2 1 ATOM 3766 N N . ASP A 1 458 ? 49.871 -7.819 7.218 1.00 30.33 ? 474 ASP A N 1 ATOM 3767 C CA . ASP A 1 458 ? 50.843 -8.910 7.283 1.00 30.79 ? 474 ASP A CA 1 ATOM 3768 C C . ASP A 1 458 ? 51.149 -9.255 8.756 1.00 30.76 ? 474 ASP A C 1 ATOM 3769 O O . ASP A 1 458 ? 50.887 -10.366 9.191 1.00 30.96 ? 474 ASP A O 1 ATOM 3770 C CB . ASP A 1 458 ? 52.114 -8.507 6.510 1.00 30.52 ? 474 ASP A CB 1 ATOM 3771 C CG . ASP A 1 458 ? 53.279 -9.499 6.669 1.00 32.06 ? 474 ASP A CG 1 ATOM 3772 O OD1 . ASP A 1 458 ? 53.203 -10.466 7.465 1.00 32.29 ? 474 ASP A OD1 1 ATOM 3773 O OD2 . ASP A 1 458 ? 54.303 -9.289 5.987 1.00 32.36 ? 474 ASP A OD2 1 ATOM 3774 N N . GLU A 1 459 ? 51.684 -8.295 9.510 1.00 31.00 ? 475 GLU A N 1 ATOM 3775 C CA . GLU A 1 459 ? 52.118 -8.535 10.887 1.00 31.51 ? 475 GLU A CA 1 ATOM 3776 C C . GLU A 1 459 ? 51.038 -9.193 11.757 1.00 30.89 ? 475 GLU A C 1 ATOM 3777 O O . GLU A 1 459 ? 51.305 -10.153 12.485 1.00 30.31 ? 475 GLU A O 1 ATOM 3778 C CB . GLU A 1 459 ? 52.601 -7.234 11.542 1.00 32.01 ? 475 GLU A CB 1 ATOM 3779 C CG . GLU A 1 459 ? 53.214 -7.456 12.942 1.00 35.79 ? 475 GLU A CG 1 ATOM 3780 C CD . GLU A 1 459 ? 53.413 -6.174 13.749 1.00 39.69 ? 475 GLU A CD 1 ATOM 3781 O OE1 . GLU A 1 459 ? 53.474 -5.071 13.154 1.00 41.41 ? 475 GLU A OE1 1 ATOM 3782 O OE2 . GLU A 1 459 ? 53.514 -6.280 14.994 1.00 41.83 ? 475 GLU A OE2 1 ATOM 3783 N N . TYR A 1 460 ? 49.814 -8.689 11.654 1.00 30.52 ? 476 TYR A N 1 ATOM 3784 C CA . TYR A 1 460 ? 48.731 -9.141 12.517 1.00 30.05 ? 476 TYR A CA 1 ATOM 3785 C C . TYR A 1 460 ? 47.898 -10.298 11.975 1.00 29.88 ? 476 TYR A C 1 ATOM 3786 O O . TYR A 1 460 ? 47.587 -11.223 12.721 1.00 29.74 ? 476 TYR A O 1 ATOM 3787 C CB . TYR A 1 460 ? 47.849 -7.957 12.909 1.00 29.85 ? 476 TYR A CB 1 ATOM 3788 C CG . TYR A 1 460 ? 48.526 -7.045 13.909 1.00 30.34 ? 476 TYR A CG 1 ATOM 3789 C CD1 . TYR A 1 460 ? 49.325 -5.981 13.491 1.00 29.24 ? 476 TYR A CD1 1 ATOM 3790 C CD2 . TYR A 1 460 ? 48.379 -7.263 15.279 1.00 30.99 ? 476 TYR A CD2 1 ATOM 3791 C CE1 . TYR A 1 460 ? 49.961 -5.150 14.423 1.00 30.14 ? 476 TYR A CE1 1 ATOM 3792 C CE2 . TYR A 1 460 ? 49.012 -6.442 16.219 1.00 30.48 ? 476 TYR A CE2 1 ATOM 3793 C CZ . TYR A 1 460 ? 49.798 -5.394 15.786 1.00 30.99 ? 476 TYR A CZ 1 ATOM 3794 O OH . TYR A 1 460 ? 50.414 -4.586 16.713 1.00 29.92 ? 476 TYR A OH 1 ATOM 3795 N N . SER A 1 461 ? 47.555 -10.263 10.687 1.00 29.45 ? 477 SER A N 1 ATOM 3796 C CA . SER A 1 461 ? 46.656 -11.265 10.107 1.00 29.44 ? 477 SER A CA 1 ATOM 3797 C C . SER A 1 461 ? 47.341 -12.336 9.251 1.00 29.34 ? 477 SER A C 1 ATOM 3798 O O . SER A 1 461 ? 46.749 -13.378 8.977 1.00 29.44 ? 477 SER A O 1 ATOM 3799 C CB . SER A 1 461 ? 45.555 -10.589 9.280 1.00 29.67 ? 477 SER A CB 1 ATOM 3800 O OG . SER A 1 461 ? 44.617 -9.926 10.117 1.00 29.80 ? 477 SER A OG 1 ATOM 3801 N N . GLY A 1 462 ? 48.574 -12.078 8.825 1.00 29.08 ? 478 GLY A N 1 ATOM 3802 C CA . GLY A 1 462 ? 49.291 -13.023 7.972 1.00 29.13 ? 478 GLY A CA 1 ATOM 3803 C C . GLY A 1 462 ? 48.632 -13.239 6.625 1.00 29.04 ? 478 GLY A C 1 ATOM 3804 O O . GLY A 1 462 ? 48.599 -14.360 6.119 1.00 28.72 ? 478 GLY A O 1 ATOM 3805 N N . ILE A 1 463 ? 48.084 -12.160 6.067 1.00 29.19 ? 479 ILE A N 1 ATOM 3806 C CA . ILE A 1 463 ? 47.477 -12.186 4.736 1.00 29.38 ? 479 ILE A CA 1 ATOM 3807 C C . ILE A 1 463 ? 48.179 -11.152 3.865 1.00 29.60 ? 479 ILE A C 1 ATOM 3808 O O . ILE A 1 463 ? 48.874 -10.278 4.387 1.00 29.76 ? 479 ILE A O 1 ATOM 3809 C CB . ILE A 1 463 ? 45.927 -11.955 4.774 1.00 29.23 ? 479 ILE A CB 1 ATOM 3810 C CG1 . ILE A 1 463 ? 45.553 -10.563 5.302 1.00 29.25 ? 479 ILE A CG1 1 ATOM 3811 C CG2 . ILE A 1 463 ? 45.242 -13.021 5.624 1.00 29.81 ? 479 ILE A CG2 1 ATOM 3812 C CD1 . ILE A 1 463 ? 45.434 -9.486 4.229 1.00 28.72 ? 479 ILE A CD1 1 ATOM 3813 N N . GLU A 1 464 ? 48.006 -11.250 2.547 1.00 29.90 ? 480 GLU A N 1 ATOM 3814 C CA . GLU A 1 464 ? 48.637 -10.304 1.625 1.00 30.32 ? 480 GLU A CA 1 ATOM 3815 C C . GLU A 1 464 ? 47.824 -10.125 0.341 1.00 30.49 ? 480 GLU A C 1 ATOM 3816 O O . GLU A 1 464 ? 47.026 -10.999 -0.006 1.00 30.26 ? 480 GLU A O 1 ATOM 3817 C CB . GLU A 1 464 ? 50.055 -10.765 1.272 1.00 30.16 ? 480 GLU A CB 1 ATOM 3818 C CG . GLU A 1 464 ? 50.110 -12.085 0.498 1.00 31.30 ? 480 GLU A CG 1 ATOM 3819 C CD . GLU A 1 464 ? 51.525 -12.516 0.185 1.00 32.41 ? 480 GLU A CD 1 ATOM 3820 O OE1 . GLU A 1 464 ? 52.446 -12.127 0.932 1.00 33.01 ? 480 GLU A OE1 1 ATOM 3821 O OE2 . GLU A 1 464 ? 51.720 -13.242 -0.809 1.00 33.50 ? 480 GLU A OE2 1 ATOM 3822 N N . PRO A 1 465 ? 48.034 -8.996 -0.371 1.00 30.74 ? 481 PRO A N 1 ATOM 3823 C CA . PRO A 1 465 ? 47.403 -8.805 -1.675 1.00 31.20 ? 481 PRO A CA 1 ATOM 3824 C C . PRO A 1 465 ? 47.742 -9.934 -2.655 1.00 31.51 ? 481 PRO A C 1 ATOM 3825 O O . PRO A 1 465 ? 48.803 -10.552 -2.542 1.00 31.76 ? 481 PRO A O 1 ATOM 3826 C CB . PRO A 1 465 ? 48.000 -7.484 -2.162 1.00 30.97 ? 481 PRO A CB 1 ATOM 3827 C CG . PRO A 1 465 ? 48.346 -6.756 -0.935 1.00 31.25 ? 481 PRO A CG 1 ATOM 3828 C CD . PRO A 1 465 ? 48.803 -7.803 0.035 1.00 30.60 ? 481 PRO A CD 1 ATOM 3829 N N . PRO A 1 466 ? 46.835 -10.213 -3.605 1.00 32.19 ? 482 PRO A N 1 ATOM 3830 C CA . PRO A 1 466 ? 47.073 -11.245 -4.617 1.00 32.21 ? 482 PRO A CA 1 ATOM 3831 C C . PRO A 1 466 ? 48.127 -10.821 -5.638 1.00 32.83 ? 482 PRO A C 1 ATOM 3832 O O . PRO A 1 466 ? 48.759 -11.676 -6.262 1.00 33.37 ? 482 PRO A O 1 ATOM 3833 C CB . PRO A 1 466 ? 45.708 -11.391 -5.292 1.00 32.26 ? 482 PRO A CB 1 ATOM 3834 C CG . PRO A 1 466 ? 45.048 -10.056 -5.115 1.00 32.30 ? 482 PRO A CG 1 ATOM 3835 C CD . PRO A 1 466 ? 45.512 -9.576 -3.761 1.00 32.04 ? 482 PRO A CD 1 ATOM 3836 N N . VAL A 1 467 ? 48.304 -9.512 -5.796 1.00 33.03 ? 483 VAL A N 1 ATOM 3837 C CA . VAL A 1 467 ? 49.267 -8.944 -6.733 1.00 33.26 ? 483 VAL A CA 1 ATOM 3838 C C . VAL A 1 467 ? 50.175 -7.980 -5.975 1.00 33.67 ? 483 VAL A C 1 ATOM 3839 O O . VAL A 1 467 ? 49.852 -7.562 -4.853 1.00 33.68 ? 483 VAL A O 1 ATOM 3840 C CB . VAL A 1 467 ? 48.574 -8.186 -7.913 1.00 33.24 ? 483 VAL A CB 1 ATOM 3841 C CG1 . VAL A 1 467 ? 47.794 -9.152 -8.815 1.00 33.44 ? 483 VAL A CG1 1 ATOM 3842 C CG2 . VAL A 1 467 ? 47.665 -7.073 -7.404 1.00 32.67 ? 483 VAL A CG2 1 ATOM 3843 N N . VAL A 1 468 ? 51.307 -7.637 -6.585 1.00 33.59 ? 484 VAL A N 1 ATOM 3844 C CA . VAL A 1 468 ? 52.242 -6.681 -6.006 1.00 33.77 ? 484 VAL A CA 1 ATOM 3845 C C . VAL A 1 468 ? 51.643 -5.276 -6.025 1.00 34.14 ? 484 VAL A C 1 ATOM 3846 O O . VAL A 1 468 ? 51.219 -4.792 -7.077 1.00 34.04 ? 484 VAL A O 1 ATOM 3847 C CB . VAL A 1 468 ? 53.608 -6.696 -6.752 1.00 33.93 ? 484 VAL A CB 1 ATOM 3848 C CG1 . VAL A 1 468 ? 54.537 -5.618 -6.210 1.00 33.80 ? 484 VAL A CG1 1 ATOM 3849 C CG2 . VAL A 1 468 ? 54.273 -8.071 -6.643 1.00 33.38 ? 484 VAL A CG2 1 ATOM 3850 N N . ARG A 1 469 ? 51.590 -4.641 -4.851 1.00 33.94 ? 485 ARG A N 1 ATOM 3851 C CA . ARG A 1 469 ? 51.161 -3.251 -4.726 1.00 34.07 ? 485 ARG A CA 1 ATOM 3852 C C . ARG A 1 469 ? 52.364 -2.377 -4.404 1.00 34.48 ? 485 ARG A C 1 ATOM 3853 O O . ARG A 1 469 ? 53.447 -2.878 -4.095 1.00 34.78 ? 485 ARG A O 1 ATOM 3854 C CB . ARG A 1 469 ? 50.092 -3.077 -3.628 1.00 33.87 ? 485 ARG A CB 1 ATOM 3855 C CG . ARG A 1 469 ? 48.911 -4.044 -3.695 1.00 33.12 ? 485 ARG A CG 1 ATOM 3856 C CD . ARG A 1 469 ? 48.066 -3.845 -4.955 1.00 30.70 ? 485 ARG A CD 1 ATOM 3857 N NE . ARG A 1 469 ? 47.035 -2.817 -4.810 1.00 30.11 ? 485 ARG A NE 1 ATOM 3858 C CZ . ARG A 1 469 ? 46.297 -2.359 -5.822 1.00 31.12 ? 485 ARG A CZ 1 ATOM 3859 N NH1 . ARG A 1 469 ? 46.489 -2.831 -7.056 1.00 30.43 ? 485 ARG A NH1 1 ATOM 3860 N NH2 . ARG A 1 469 ? 45.372 -1.430 -5.609 1.00 28.74 ? 485 ARG A NH2 1 ATOM 3861 N N . SER A 1 470 ? 52.168 -1.067 -4.482 1.00 34.81 ? 486 SER A N 1 ATOM 3862 C CA . SER A 1 470 ? 53.213 -0.110 -4.165 1.00 35.28 ? 486 SER A CA 1 ATOM 3863 C C . SER A 1 470 ? 52.576 1.166 -3.655 1.00 35.42 ? 486 SER A C 1 ATOM 3864 O O . SER A 1 470 ? 51.359 1.220 -3.434 1.00 35.43 ? 486 SER A O 1 ATOM 3865 C CB . SER A 1 470 ? 54.095 0.172 -5.396 1.00 35.45 ? 486 SER A CB 1 ATOM 3866 O OG . SER A 1 470 ? 53.376 0.867 -6.402 1.00 35.33 ? 486 SER A OG 1 ATOM 3867 N N . GLU A 1 471 ? 53.396 2.194 -3.469 1.00 35.76 ? 487 GLU A N 1 ATOM 3868 C CA . GLU A 1 471 ? 52.902 3.495 -3.042 1.00 36.08 ? 487 GLU A CA 1 ATOM 3869 C C . GLU A 1 471 ? 52.168 4.242 -4.163 1.00 36.55 ? 487 GLU A C 1 ATOM 3870 O O . GLU A 1 471 ? 51.589 5.308 -3.934 1.00 36.77 ? 487 GLU A O 1 ATOM 3871 C CB . GLU A 1 471 ? 54.036 4.330 -2.450 1.00 36.07 ? 487 GLU A CB 1 ATOM 3872 C CG . GLU A 1 471 ? 54.684 3.687 -1.225 1.00 36.18 ? 487 GLU A CG 1 ATOM 3873 C CD . GLU A 1 471 ? 53.767 3.646 0.009 1.00 36.26 ? 487 GLU A CD 1 ATOM 3874 O OE1 . GLU A 1 471 ? 52.719 4.331 0.029 1.00 36.16 ? 487 GLU A OE1 1 ATOM 3875 O OE2 . GLU A 1 471 ? 54.115 2.931 0.970 1.00 36.13 ? 487 GLU A OE2 1 ATOM 3876 N N . LYS A 1 472 ? 52.176 3.670 -5.366 1.00 36.77 ? 488 LYS A N 1 ATOM 3877 C CA . LYS A 1 472 ? 51.324 4.157 -6.454 1.00 37.14 ? 488 LYS A CA 1 ATOM 3878 C C . LYS A 1 472 ? 49.854 3.794 -6.210 1.00 36.62 ? 488 LYS A C 1 ATOM 3879 O O . LYS A 1 472 ? 48.946 4.437 -6.740 1.00 36.67 ? 488 LYS A O 1 ATOM 3880 C CB . LYS A 1 472 ? 51.790 3.597 -7.799 1.00 37.50 ? 488 LYS A CB 1 ATOM 3881 C CG . LYS A 1 472 ? 53.151 4.121 -8.252 1.00 39.86 ? 488 LYS A CG 1 ATOM 3882 C CD . LYS A 1 472 ? 53.575 3.440 -9.549 1.00 43.96 ? 488 LYS A CD 1 ATOM 3883 C CE . LYS A 1 472 ? 54.923 3.960 -10.036 1.00 46.70 ? 488 LYS A CE 1 ATOM 3884 N NZ . LYS A 1 472 ? 55.286 3.371 -11.364 1.00 48.54 ? 488 LYS A NZ 1 ATOM 3885 N N . ASP A 1 473 ? 49.630 2.757 -5.408 1.00 35.69 ? 489 ASP A N 1 ATOM 3886 C CA . ASP A 1 473 ? 48.288 2.347 -5.020 1.00 34.95 ? 489 ASP A CA 1 ATOM 3887 C C . ASP A 1 473 ? 47.962 2.921 -3.644 1.00 34.64 ? 489 ASP A C 1 ATOM 3888 O O . ASP A 1 473 ? 48.866 3.313 -2.906 1.00 34.49 ? 489 ASP A O 1 ATOM 3889 C CB . ASP A 1 473 ? 48.201 0.822 -5.000 1.00 34.83 ? 489 ASP A CB 1 ATOM 3890 C CG . ASP A 1 473 ? 48.729 0.197 -6.283 1.00 34.60 ? 489 ASP A CG 1 ATOM 3891 O OD1 . ASP A 1 473 ? 48.169 0.487 -7.362 1.00 34.60 ? 489 ASP A OD1 1 ATOM 3892 O OD2 . ASP A 1 473 ? 49.713 -0.568 -6.217 1.00 33.57 ? 489 ASP A OD2 1 ATOM 3893 N N . PHE A 1 474 ? 46.674 2.988 -3.309 1.00 33.96 ? 490 PHE A N 1 ATOM 3894 C CA . PHE A 1 474 ? 46.260 3.403 -1.969 1.00 33.19 ? 490 PHE A CA 1 ATOM 3895 C C . PHE A 1 474 ? 45.027 2.618 -1.556 1.00 32.58 ? 490 PHE A C 1 ATOM 3896 O O . PHE A 1 474 ? 43.905 2.975 -1.889 1.00 32.15 ? 490 PHE A O 1 ATOM 3897 C CB . PHE A 1 474 ? 46.039 4.918 -1.873 1.00 33.27 ? 490 PHE A CB 1 ATOM 3898 C CG . PHE A 1 474 ? 45.860 5.407 -0.461 1.00 33.23 ? 490 PHE A CG 1 ATOM 3899 C CD1 . PHE A 1 474 ? 46.892 5.288 0.466 1.00 33.48 ? 490 PHE A CD1 1 ATOM 3900 C CD2 . PHE A 1 474 ? 44.660 5.967 -0.052 1.00 33.57 ? 490 PHE A CD2 1 ATOM 3901 C CE1 . PHE A 1 474 ? 46.728 5.721 1.787 1.00 33.09 ? 490 PHE A CE1 1 ATOM 3902 C CE2 . PHE A 1 474 ? 44.488 6.403 1.271 1.00 33.78 ? 490 PHE A CE2 1 ATOM 3903 C CZ . PHE A 1 474 ? 45.526 6.277 2.186 1.00 32.18 ? 490 PHE A CZ 1 ATOM 3904 N N . ASP A 1 475 ? 45.259 1.546 -0.808 1.00 31.83 ? 491 ASP A N 1 ATOM 3905 C CA . ASP A 1 475 ? 44.284 0.461 -0.700 1.00 31.31 ? 491 ASP A CA 1 ATOM 3906 C C . ASP A 1 475 ? 43.321 0.540 0.480 1.00 30.78 ? 491 ASP A C 1 ATOM 3907 O O . ASP A 1 475 ? 42.241 -0.043 0.435 1.00 30.74 ? 491 ASP A O 1 ATOM 3908 C CB . ASP A 1 475 ? 45.015 -0.883 -0.723 1.00 31.01 ? 491 ASP A CB 1 ATOM 3909 C CG . ASP A 1 475 ? 45.657 -1.167 -2.074 1.00 31.30 ? 491 ASP A CG 1 ATOM 3910 O OD1 . ASP A 1 475 ? 44.969 -0.983 -3.098 1.00 30.93 ? 491 ASP A OD1 1 ATOM 3911 O OD2 . ASP A 1 475 ? 46.838 -1.580 -2.113 1.00 31.09 ? 491 ASP A OD2 1 ATOM 3912 N N . ALA A 1 476 ? 43.705 1.271 1.520 1.00 30.43 ? 492 ALA A N 1 ATOM 3913 C CA . ALA A 1 476 ? 42.903 1.353 2.747 1.00 29.87 ? 492 ALA A CA 1 ATOM 3914 C C . ALA A 1 476 ? 41.435 1.772 2.548 1.00 29.43 ? 492 ALA A C 1 ATOM 3915 O O . ALA A 1 476 ? 40.545 1.142 3.126 1.00 29.39 ? 492 ALA A O 1 ATOM 3916 C CB . ALA A 1 476 ? 43.596 2.247 3.792 1.00 30.14 ? 492 ALA A CB 1 ATOM 3917 N N . PRO A 1 477 ? 41.164 2.813 1.722 1.00 29.06 ? 493 PRO A N 1 ATOM 3918 C CA . PRO A 1 477 ? 39.765 3.247 1.575 1.00 28.67 ? 493 PRO A CA 1 ATOM 3919 C C . PRO A 1 477 ? 38.856 2.273 0.816 1.00 28.65 ? 493 PRO A C 1 ATOM 3920 O O . PRO A 1 477 ? 37.634 2.484 0.768 1.00 28.54 ? 493 PRO A O 1 ATOM 3921 C CB . PRO A 1 477 ? 39.882 4.584 0.820 1.00 28.62 ? 493 PRO A CB 1 ATOM 3922 C CG . PRO A 1 477 ? 41.289 5.015 1.002 1.00 28.45 ? 493 PRO A CG 1 ATOM 3923 C CD . PRO A 1 477 ? 42.073 3.732 1.011 1.00 29.12 ? 493 PRO A CD 1 ATOM 3924 N N . ALA A 1 478 ? 39.429 1.208 0.255 1.00 28.55 ? 494 ALA A N 1 ATOM 3925 C CA . ALA A 1 478 ? 38.624 0.129 -0.320 1.00 28.55 ? 494 ALA A CA 1 ATOM 3926 C C . ALA A 1 478 ? 37.768 -0.574 0.738 1.00 28.72 ? 494 ALA A C 1 ATOM 3927 O O . ALA A 1 478 ? 36.842 -1.310 0.398 1.00 28.90 ? 494 ALA A O 1 ATOM 3928 C CB . ALA A 1 478 ? 39.499 -0.873 -1.066 1.00 28.34 ? 494 ALA A CB 1 ATOM 3929 N N . LYS A 1 479 ? 38.081 -0.355 2.017 1.00 29.00 ? 495 LYS A N 1 ATOM 3930 C CA . LYS A 1 479 ? 37.217 -0.812 3.103 1.00 28.96 ? 495 LYS A CA 1 ATOM 3931 C C . LYS A 1 479 ? 36.215 0.300 3.411 1.00 29.15 ? 495 LYS A C 1 ATOM 3932 O O . LYS A 1 479 ? 36.608 1.457 3.613 1.00 28.93 ? 495 LYS A O 1 ATOM 3933 C CB . LYS A 1 479 ? 38.038 -1.169 4.354 1.00 29.55 ? 495 LYS A CB 1 ATOM 3934 C CG . LYS A 1 479 ? 37.202 -1.544 5.588 1.00 29.74 ? 495 LYS A CG 1 ATOM 3935 C CD . LYS A 1 479 ? 36.434 -2.853 5.378 1.00 30.60 ? 495 LYS A CD 1 ATOM 3936 C CE . LYS A 1 479 ? 35.404 -3.078 6.487 1.00 31.15 ? 495 LYS A CE 1 ATOM 3937 N NZ . LYS A 1 479 ? 34.305 -4.003 6.053 1.00 30.11 ? 495 LYS A NZ 1 ATOM 3938 N N . TYR A 1 480 ? 34.928 -0.051 3.445 1.00 29.05 ? 496 TYR A N 1 ATOM 3939 C CA . TYR A 1 480 ? 33.865 0.945 3.556 1.00 29.31 ? 496 TYR A CA 1 ATOM 3940 C C . TYR A 1 480 ? 34.077 1.912 4.722 1.00 29.01 ? 496 TYR A C 1 ATOM 3941 O O . TYR A 1 480 ? 34.006 3.126 4.546 1.00 28.98 ? 496 TYR A O 1 ATOM 3942 C CB . TYR A 1 480 ? 32.478 0.293 3.667 1.00 29.34 ? 496 TYR A CB 1 ATOM 3943 C CG . TYR A 1 480 ? 31.388 1.311 3.948 1.00 30.60 ? 496 TYR A CG 1 ATOM 3944 C CD1 . TYR A 1 480 ? 30.920 2.156 2.937 1.00 30.76 ? 496 TYR A CD1 1 ATOM 3945 C CD2 . TYR A 1 480 ? 30.852 1.454 5.227 1.00 30.86 ? 496 TYR A CD2 1 ATOM 3946 C CE1 . TYR A 1 480 ? 29.942 3.103 3.187 1.00 31.26 ? 496 TYR A CE1 1 ATOM 3947 C CE2 . TYR A 1 480 ? 29.868 2.402 5.485 1.00 31.85 ? 496 TYR A CE2 1 ATOM 3948 C CZ . TYR A 1 480 ? 29.422 3.220 4.464 1.00 32.86 ? 496 TYR A CZ 1 ATOM 3949 O OH . TYR A 1 480 ? 28.448 4.154 4.716 1.00 34.29 ? 496 TYR A OH 1 ATOM 3950 N N . HIS A 1 481 ? 34.342 1.366 5.905 1.00 28.88 ? 497 HIS A N 1 ATOM 3951 C CA . HIS A 1 481 ? 34.502 2.187 7.109 1.00 28.91 ? 497 HIS A CA 1 ATOM 3952 C C . HIS A 1 481 ? 35.601 3.236 6.971 1.00 28.80 ? 497 HIS A C 1 ATOM 3953 O O . HIS A 1 481 ? 35.520 4.308 7.567 1.00 29.23 ? 497 HIS A O 1 ATOM 3954 C CB . HIS A 1 481 ? 34.773 1.301 8.324 1.00 28.69 ? 497 HIS A CB 1 ATOM 3955 C CG . HIS A 1 481 ? 33.640 0.386 8.665 1.00 29.08 ? 497 HIS A CG 1 ATOM 3956 N ND1 . HIS A 1 481 ? 33.217 -0.622 7.826 1.00 29.35 ? 497 HIS A ND1 1 ATOM 3957 C CD2 . HIS A 1 481 ? 32.849 0.319 9.762 1.00 29.31 ? 497 HIS A CD2 1 ATOM 3958 C CE1 . HIS A 1 481 ? 32.213 -1.268 8.387 1.00 29.37 ? 497 HIS A CE1 1 ATOM 3959 N NE2 . HIS A 1 481 ? 31.973 -0.720 9.567 1.00 29.57 ? 497 HIS A NE2 1 ATOM 3960 N N . ILE A 1 482 ? 36.628 2.926 6.188 1.00 28.91 ? 498 ILE A N 1 ATOM 3961 C CA . ILE A 1 482 ? 37.743 3.846 5.998 1.00 29.00 ? 498 ILE A CA 1 ATOM 3962 C C . ILE A 1 482 ? 37.372 5.015 5.068 1.00 29.26 ? 498 ILE A C 1 ATOM 3963 O O . ILE A 1 482 ? 37.699 6.177 5.358 1.00 28.90 ? 498 ILE A O 1 ATOM 3964 C CB . ILE A 1 482 ? 39.044 3.089 5.596 1.00 29.13 ? 498 ILE A CB 1 ATOM 3965 C CG1 . ILE A 1 482 ? 39.457 2.143 6.744 1.00 29.20 ? 498 ILE A CG1 1 ATOM 3966 C CG2 . ILE A 1 482 ? 40.171 4.064 5.280 1.00 28.53 ? 498 ILE A CG2 1 ATOM 3967 C CD1 . ILE A 1 482 ? 40.743 1.380 6.519 1.00 31.25 ? 498 ILE A CD1 1 ATOM 3968 N N . SER A 1 483 ? 36.661 4.714 3.981 1.00 29.63 ? 499 SER A N 1 ATOM 3969 C CA . SER A 1 483 ? 36.106 5.758 3.105 1.00 29.92 ? 499 SER A CA 1 ATOM 3970 C C . SER A 1 483 ? 35.052 6.610 3.815 1.00 30.05 ? 499 SER A C 1 ATOM 3971 O O . SER A 1 483 ? 34.958 7.817 3.573 1.00 30.30 ? 499 SER A O 1 ATOM 3972 C CB . SER A 1 483 ? 35.489 5.144 1.841 1.00 29.99 ? 499 SER A CB 1 ATOM 3973 O OG . SER A 1 483 ? 36.473 4.893 0.850 1.00 30.44 ? 499 SER A OG 1 ATOM 3974 N N . ALA A 1 484 ? 34.275 5.979 4.696 1.00 30.15 ? 500 ALA A N 1 ATOM 3975 C CA . ALA A 1 484 ? 33.136 6.626 5.353 1.00 30.17 ? 500 ALA A CA 1 ATOM 3976 C C . ALA A 1 484 ? 33.450 7.221 6.730 1.00 30.42 ? 500 ALA A C 1 ATOM 3977 O O . ALA A 1 484 ? 32.550 7.733 7.397 1.00 30.37 ? 500 ALA A O 1 ATOM 3978 C CB . ALA A 1 484 ? 31.967 5.650 5.461 1.00 30.07 ? 500 ALA A CB 1 ATOM 3979 N N . ASP A 1 485 ? 34.712 7.157 7.150 1.00 30.38 ? 501 ASP A N 1 ATOM 3980 C CA . ASP A 1 485 ? 35.131 7.724 8.445 1.00 30.59 ? 501 ASP A CA 1 ATOM 3981 C C . ASP A 1 485 ? 34.272 7.174 9.596 1.00 30.46 ? 501 ASP A C 1 ATOM 3982 O O . ASP A 1 485 ? 33.642 7.922 10.349 1.00 30.91 ? 501 ASP A O 1 ATOM 3983 C CB . ASP A 1 485 ? 35.128 9.270 8.389 1.00 30.48 ? 501 ASP A CB 1 ATOM 3984 C CG . ASP A 1 485 ? 35.535 9.928 9.718 1.00 31.44 ? 501 ASP A CG 1 ATOM 3985 O OD1 . ASP A 1 485 ? 36.470 9.438 10.387 1.00 30.17 ? 501 ASP A OD1 1 ATOM 3986 O OD2 . ASP A 1 485 ? 34.919 10.952 10.081 1.00 31.05 ? 501 ASP A OD2 1 ATOM 3987 N N . VAL A 1 486 ? 34.227 5.851 9.702 1.00 30.46 ? 502 VAL A N 1 ATOM 3988 C CA . VAL A 1 486 ? 33.568 5.183 10.829 1.00 29.99 ? 502 VAL A CA 1 ATOM 3989 C C . VAL A 1 486 ? 34.647 4.454 11.629 1.00 29.88 ? 502 VAL A C 1 ATOM 3990 O O . VAL A 1 486 ? 35.360 3.607 11.094 1.00 29.94 ? 502 VAL A O 1 ATOM 3991 C CB . VAL A 1 486 ? 32.457 4.204 10.367 1.00 30.11 ? 502 VAL A CB 1 ATOM 3992 C CG1 . VAL A 1 486 ? 31.840 3.464 11.557 1.00 29.83 ? 502 VAL A CG1 1 ATOM 3993 C CG2 . VAL A 1 486 ? 31.370 4.941 9.579 1.00 30.02 ? 502 VAL A CG2 1 ATOM 3994 N N . GLU A 1 487 ? 34.781 4.824 12.904 1.00 29.60 ? 503 GLU A N 1 ATOM 3995 C CA . GLU A 1 487 ? 35.727 4.197 13.831 1.00 28.97 ? 503 GLU A CA 1 ATOM 3996 C C . GLU A 1 487 ? 35.540 2.677 13.827 1.00 28.39 ? 503 GLU A C 1 ATOM 3997 O O . GLU A 1 487 ? 34.411 2.192 13.748 1.00 28.56 ? 503 GLU A O 1 ATOM 3998 C CB . GLU A 1 487 ? 35.521 4.792 15.234 1.00 29.06 ? 503 GLU A CB 1 ATOM 3999 C CG . GLU A 1 487 ? 36.541 4.382 16.290 1.00 29.47 ? 503 GLU A CG 1 ATOM 4000 C CD . GLU A 1 487 ? 36.012 3.315 17.229 1.00 30.23 ? 503 GLU A CD 1 ATOM 4001 O OE1 . GLU A 1 487 ? 35.137 2.531 16.807 1.00 29.37 ? 503 GLU A OE1 1 ATOM 4002 O OE2 . GLU A 1 487 ? 36.473 3.265 18.395 1.00 30.33 ? 503 GLU A OE2 1 ATOM 4003 N N . TYR A 1 488 ? 36.640 1.928 13.886 1.00 27.71 ? 504 TYR A N 1 ATOM 4004 C CA . TYR A 1 488 ? 36.562 0.466 13.794 1.00 27.25 ? 504 TYR A CA 1 ATOM 4005 C C . TYR A 1 488 ? 36.818 -0.289 15.105 1.00 27.14 ? 504 TYR A C 1 ATOM 4006 O O . TYR A 1 488 ? 36.406 -1.434 15.239 1.00 27.00 ? 504 TYR A O 1 ATOM 4007 C CB . TYR A 1 488 ? 37.468 -0.081 12.681 1.00 26.96 ? 504 TYR A CB 1 ATOM 4008 C CG . TYR A 1 488 ? 36.861 -1.264 11.962 1.00 26.94 ? 504 TYR A CG 1 ATOM 4009 C CD1 . TYR A 1 488 ? 35.934 -1.074 10.928 1.00 26.23 ? 504 TYR A CD1 1 ATOM 4010 C CD2 . TYR A 1 488 ? 37.196 -2.574 12.319 1.00 26.34 ? 504 TYR A CD2 1 ATOM 4011 C CE1 . TYR A 1 488 ? 35.355 -2.156 10.272 1.00 26.31 ? 504 TYR A CE1 1 ATOM 4012 C CE2 . TYR A 1 488 ? 36.625 -3.668 11.664 1.00 26.56 ? 504 TYR A CE2 1 ATOM 4013 C CZ . TYR A 1 488 ? 35.708 -3.449 10.639 1.00 26.79 ? 504 TYR A CZ 1 ATOM 4014 O OH . TYR A 1 488 ? 35.135 -4.521 9.995 1.00 26.10 ? 504 TYR A OH 1 ATOM 4015 N N . LEU A 1 489 ? 37.475 0.345 16.071 1.00 27.23 ? 505 LEU A N 1 ATOM 4016 C CA . LEU A 1 489 ? 37.766 -0.324 17.343 1.00 27.57 ? 505 LEU A CA 1 ATOM 4017 C C . LEU A 1 489 ? 36.503 -0.868 18.019 1.00 27.77 ? 505 LEU A C 1 ATOM 4018 O O . LEU A 1 489 ? 36.554 -1.878 18.729 1.00 28.71 ? 505 LEU A O 1 ATOM 4019 C CB . LEU A 1 489 ? 38.512 0.610 18.302 1.00 27.58 ? 505 LEU A CB 1 ATOM 4020 C CG . LEU A 1 489 ? 39.306 -0.105 19.400 1.00 27.12 ? 505 LEU A CG 1 ATOM 4021 C CD1 . LEU A 1 489 ? 40.568 -0.761 18.815 1.00 26.25 ? 505 LEU A CD1 1 ATOM 4022 C CD2 . LEU A 1 489 ? 39.654 0.865 20.524 1.00 27.23 ? 505 LEU A CD2 1 ATOM 4023 N N . ARG A 1 490 ? 35.375 -0.202 17.788 1.00 27.73 ? 506 ARG A N 1 ATOM 4024 C CA . ARG A 1 490 ? 34.073 -0.665 18.277 1.00 27.84 ? 506 ARG A CA 1 ATOM 4025 C C . ARG A 1 490 ? 33.845 -2.155 18.023 1.00 27.83 ? 506 ARG A C 1 ATOM 4026 O O . ARG A 1 490 ? 33.320 -2.862 18.883 1.00 28.07 ? 506 ARG A O 1 ATOM 4027 C CB . ARG A 1 490 ? 32.938 0.166 17.666 1.00 27.91 ? 506 ARG A CB 1 ATOM 4028 C CG . ARG A 1 490 ? 32.857 0.125 16.130 1.00 28.03 ? 506 ARG A CG 1 ATOM 4029 C CD . ARG A 1 490 ? 31.801 1.082 15.613 1.00 28.33 ? 506 ARG A CD 1 ATOM 4030 N NE . ARG A 1 490 ? 32.148 2.478 15.888 1.00 27.71 ? 506 ARG A NE 1 ATOM 4031 C CZ . ARG A 1 490 ? 31.400 3.519 15.542 1.00 28.50 ? 506 ARG A CZ 1 ATOM 4032 N NH1 . ARG A 1 490 ? 30.243 3.340 14.912 1.00 29.20 ? 506 ARG A NH1 1 ATOM 4033 N NH2 . ARG A 1 490 ? 31.804 4.746 15.836 1.00 30.24 ? 506 ARG A NH2 1 ATOM 4034 N N . TYR A 1 491 ? 34.262 -2.634 16.852 1.00 27.27 ? 507 TYR A N 1 ATOM 4035 C CA . TYR A 1 491 ? 34.055 -4.026 16.493 1.00 27.16 ? 507 TYR A CA 1 ATOM 4036 C C . TYR A 1 491 ? 34.999 -4.987 17.219 1.00 26.79 ? 507 TYR A C 1 ATOM 4037 O O . TYR A 1 491 ? 34.612 -6.110 17.519 1.00 26.84 ? 507 TYR A O 1 ATOM 4038 C CB . TYR A 1 491 ? 34.149 -4.216 14.971 1.00 27.19 ? 507 TYR A CB 1 ATOM 4039 C CG . TYR A 1 491 ? 33.197 -3.331 14.199 1.00 27.63 ? 507 TYR A CG 1 ATOM 4040 C CD1 . TYR A 1 491 ? 31.821 -3.572 14.215 1.00 28.61 ? 507 TYR A CD1 1 ATOM 4041 C CD2 . TYR A 1 491 ? 33.670 -2.252 13.457 1.00 28.16 ? 507 TYR A CD2 1 ATOM 4042 C CE1 . TYR A 1 491 ? 30.936 -2.756 13.503 1.00 29.18 ? 507 TYR A CE1 1 ATOM 4043 C CE2 . TYR A 1 491 ? 32.796 -1.429 12.744 1.00 28.65 ? 507 TYR A CE2 1 ATOM 4044 C CZ . TYR A 1 491 ? 31.435 -1.687 12.774 1.00 29.42 ? 507 TYR A CZ 1 ATOM 4045 O OH . TYR A 1 491 ? 30.573 -0.880 12.074 1.00 30.44 ? 507 TYR A OH 1 ATOM 4046 N N . LEU A 1 492 ? 36.237 -4.561 17.469 1.00 26.57 ? 508 LEU A N 1 ATOM 4047 C CA . LEU A 1 492 ? 37.156 -5.348 18.282 1.00 26.64 ? 508 LEU A CA 1 ATOM 4048 C C . LEU A 1 492 ? 36.597 -5.481 19.703 1.00 26.46 ? 508 LEU A C 1 ATOM 4049 O O . LEU A 1 492 ? 36.571 -6.575 20.272 1.00 26.57 ? 508 LEU A O 1 ATOM 4050 C CB . LEU A 1 492 ? 38.556 -4.718 18.315 1.00 26.40 ? 508 LEU A CB 1 ATOM 4051 C CG . LEU A 1 492 ? 39.608 -5.466 19.148 1.00 26.76 ? 508 LEU A CG 1 ATOM 4052 C CD1 . LEU A 1 492 ? 39.752 -6.935 18.726 1.00 27.08 ? 508 LEU A CD1 1 ATOM 4053 C CD2 . LEU A 1 492 ? 40.953 -4.767 19.100 1.00 24.89 ? 508 LEU A CD2 1 ATOM 4054 N N . VAL A 1 493 ? 36.149 -4.361 20.254 1.00 26.65 ? 509 VAL A N 1 ATOM 4055 C CA . VAL A 1 493 ? 35.517 -4.339 21.574 1.00 26.76 ? 509 VAL A CA 1 ATOM 4056 C C . VAL A 1 493 ? 34.281 -5.249 21.569 1.00 27.23 ? 509 VAL A C 1 ATOM 4057 O O . VAL A 1 493 ? 34.124 -6.105 22.444 1.00 27.24 ? 509 VAL A O 1 ATOM 4058 C CB . VAL A 1 493 ? 35.161 -2.895 22.000 1.00 26.77 ? 509 VAL A CB 1 ATOM 4059 C CG1 . VAL A 1 493 ? 34.479 -2.870 23.391 1.00 26.01 ? 509 VAL A CG1 1 ATOM 4060 C CG2 . VAL A 1 493 ? 36.416 -2.031 22.011 1.00 25.95 ? 509 VAL A CG2 1 ATOM 4061 N N . SER A 1 494 ? 33.436 -5.084 20.554 1.00 27.71 ? 510 SER A N 1 ATOM 4062 C CA . SER A 1 494 ? 32.220 -5.883 20.403 1.00 28.22 ? 510 SER A CA 1 ATOM 4063 C C . SER A 1 494 ? 32.476 -7.386 20.384 1.00 28.46 ? 510 SER A C 1 ATOM 4064 O O . SER A 1 494 ? 31.800 -8.130 21.084 1.00 28.92 ? 510 SER A O 1 ATOM 4065 C CB . SER A 1 494 ? 31.461 -5.481 19.139 1.00 28.22 ? 510 SER A CB 1 ATOM 4066 O OG . SER A 1 494 ? 30.435 -6.416 18.863 1.00 28.63 ? 510 SER A OG 1 ATOM 4067 N N . PHE A 1 495 ? 33.442 -7.831 19.582 1.00 28.56 ? 511 PHE A N 1 ATOM 4068 C CA . PHE A 1 495 ? 33.720 -9.264 19.451 1.00 28.61 ? 511 PHE A CA 1 ATOM 4069 C C . PHE A 1 495 ? 34.247 -9.871 20.757 1.00 28.91 ? 511 PHE A C 1 ATOM 4070 O O . PHE A 1 495 ? 34.022 -11.043 21.029 1.00 29.19 ? 511 PHE A O 1 ATOM 4071 C CB . PHE A 1 495 ? 34.662 -9.543 18.278 1.00 28.47 ? 511 PHE A CB 1 ATOM 4072 C CG . PHE A 1 495 ? 33.956 -9.670 16.941 1.00 28.49 ? 511 PHE A CG 1 ATOM 4073 C CD1 . PHE A 1 495 ? 33.041 -8.708 16.520 1.00 28.47 ? 511 PHE A CD1 1 ATOM 4074 C CD2 . PHE A 1 495 ? 34.207 -10.761 16.111 1.00 28.58 ? 511 PHE A CD2 1 ATOM 4075 C CE1 . PHE A 1 495 ? 32.389 -8.824 15.281 1.00 29.21 ? 511 PHE A CE1 1 ATOM 4076 C CE2 . PHE A 1 495 ? 33.564 -10.892 14.872 1.00 27.84 ? 511 PHE A CE2 1 ATOM 4077 C CZ . PHE A 1 495 ? 32.656 -9.922 14.456 1.00 28.68 ? 511 PHE A CZ 1 ATOM 4078 N N . ILE A 1 496 ? 34.912 -9.062 21.574 1.00 29.02 ? 512 ILE A N 1 ATOM 4079 C CA . ILE A 1 496 ? 35.306 -9.497 22.917 1.00 29.44 ? 512 ILE A CA 1 ATOM 4080 C C . ILE A 1 496 ? 34.089 -9.533 23.847 1.00 29.35 ? 512 ILE A C 1 ATOM 4081 O O . ILE A 1 496 ? 33.754 -10.589 24.375 1.00 29.62 ? 512 ILE A O 1 ATOM 4082 C CB . ILE A 1 496 ? 36.426 -8.613 23.517 1.00 29.31 ? 512 ILE A CB 1 ATOM 4083 C CG1 . ILE A 1 496 ? 37.710 -8.763 22.694 1.00 28.98 ? 512 ILE A CG1 1 ATOM 4084 C CG2 . ILE A 1 496 ? 36.686 -8.984 24.989 1.00 30.14 ? 512 ILE A CG2 1 ATOM 4085 C CD1 . ILE A 1 496 ? 38.689 -7.618 22.851 1.00 28.33 ? 512 ILE A CD1 1 ATOM 4086 N N . ILE A 1 497 ? 33.420 -8.394 24.022 1.00 29.63 ? 513 ILE A N 1 ATOM 4087 C CA . ILE A 1 497 ? 32.362 -8.291 25.035 1.00 29.93 ? 513 ILE A CA 1 ATOM 4088 C C . ILE A 1 497 ? 31.085 -9.062 24.688 1.00 30.05 ? 513 ILE A C 1 ATOM 4089 O O . ILE A 1 497 ? 30.367 -9.495 25.593 1.00 30.02 ? 513 ILE A O 1 ATOM 4090 C CB . ILE A 1 497 ? 32.036 -6.818 25.452 1.00 29.98 ? 513 ILE A CB 1 ATOM 4091 C CG1 . ILE A 1 497 ? 31.391 -6.037 24.303 1.00 29.70 ? 513 ILE A CG1 1 ATOM 4092 C CG2 . ILE A 1 497 ? 33.284 -6.126 26.037 1.00 30.12 ? 513 ILE A CG2 1 ATOM 4093 C CD1 . ILE A 1 497 ? 30.892 -4.650 24.689 1.00 29.96 ? 513 ILE A CD1 1 ATOM 4094 N N . GLN A 1 498 ? 30.816 -9.265 23.397 1.00 29.63 ? 514 GLN A N 1 ATOM 4095 C CA . GLN A 1 498 ? 29.637 -10.042 22.998 1.00 29.53 ? 514 GLN A CA 1 ATOM 4096 C C . GLN A 1 498 ? 29.651 -11.471 23.561 1.00 29.63 ? 514 GLN A C 1 ATOM 4097 O O . GLN A 1 498 ? 28.591 -12.069 23.763 1.00 29.64 ? 514 GLN A O 1 ATOM 4098 C CB . GLN A 1 498 ? 29.427 -10.044 21.472 1.00 29.53 ? 514 GLN A CB 1 ATOM 4099 C CG . GLN A 1 498 ? 30.382 -10.937 20.676 1.00 29.15 ? 514 GLN A CG 1 ATOM 4100 C CD . GLN A 1 498 ? 30.180 -10.827 19.163 1.00 28.85 ? 514 GLN A CD 1 ATOM 4101 O OE1 . GLN A 1 498 ? 29.977 -11.832 18.493 1.00 29.90 ? 514 GLN A OE1 1 ATOM 4102 N NE2 . GLN A 1 498 ? 30.204 -9.607 18.633 1.00 28.43 ? 514 GLN A NE2 1 ATOM 4103 N N . PHE A 1 499 ? 30.838 -12.014 23.820 1.00 29.71 ? 515 PHE A N 1 ATOM 4104 C CA . PHE A 1 499 ? 30.928 -13.328 24.454 1.00 30.09 ? 515 PHE A CA 1 ATOM 4105 C C . PHE A 1 499 ? 30.684 -13.258 25.957 1.00 30.35 ? 515 PHE A C 1 ATOM 4106 O O . PHE A 1 499 ? 30.199 -14.222 26.548 1.00 30.74 ? 515 PHE A O 1 ATOM 4107 C CB . PHE A 1 499 ? 32.245 -14.043 24.118 1.00 29.66 ? 515 PHE A CB 1 ATOM 4108 C CG . PHE A 1 499 ? 32.290 -14.556 22.703 1.00 29.48 ? 515 PHE A CG 1 ATOM 4109 C CD1 . PHE A 1 499 ? 32.704 -13.729 21.665 1.00 29.10 ? 515 PHE A CD1 1 ATOM 4110 C CD2 . PHE A 1 499 ? 31.861 -15.845 22.400 1.00 28.72 ? 515 PHE A CD2 1 ATOM 4111 C CE1 . PHE A 1 499 ? 32.720 -14.190 20.338 1.00 28.44 ? 515 PHE A CE1 1 ATOM 4112 C CE2 . PHE A 1 499 ? 31.868 -16.314 21.082 1.00 29.37 ? 515 PHE A CE2 1 ATOM 4113 C CZ . PHE A 1 499 ? 32.301 -15.481 20.052 1.00 28.58 ? 515 PHE A CZ 1 ATOM 4114 N N . GLN A 1 500 ? 31.017 -12.123 26.565 1.00 30.59 ? 516 GLN A N 1 ATOM 4115 C CA . GLN A 1 500 ? 30.669 -11.883 27.975 1.00 31.08 ? 516 GLN A CA 1 ATOM 4116 C C . GLN A 1 500 ? 29.144 -11.802 28.148 1.00 31.46 ? 516 GLN A C 1 ATOM 4117 O O . GLN A 1 500 ? 28.582 -12.418 29.060 1.00 31.55 ? 516 GLN A O 1 ATOM 4118 C CB . GLN A 1 500 ? 31.345 -10.613 28.505 1.00 30.80 ? 516 GLN A CB 1 ATOM 4119 C CG . GLN A 1 500 ? 32.863 -10.650 28.465 1.00 30.44 ? 516 GLN A CG 1 ATOM 4120 C CD . GLN A 1 500 ? 33.505 -9.405 29.037 1.00 31.61 ? 516 GLN A CD 1 ATOM 4121 O OE1 . GLN A 1 500 ? 34.099 -8.615 28.303 1.00 31.17 ? 516 GLN A OE1 1 ATOM 4122 N NE2 . GLN A 1 500 ? 33.398 -9.221 30.365 1.00 30.85 ? 516 GLN A NE2 1 ATOM 4123 N N . PHE A 1 501 ? 28.488 -11.053 27.260 1.00 32.12 ? 517 PHE A N 1 ATOM 4124 C CA . PHE A 1 501 ? 27.024 -10.943 27.253 1.00 32.55 ? 517 PHE A CA 1 ATOM 4125 C C . PHE A 1 501 ? 26.368 -12.290 26.958 1.00 32.91 ? 517 PHE A C 1 ATOM 4126 O O . PHE A 1 501 ? 25.415 -12.685 27.638 1.00 32.97 ? 517 PHE A O 1 ATOM 4127 C CB . PHE A 1 501 ? 26.535 -9.916 26.222 1.00 32.55 ? 517 PHE A CB 1 ATOM 4128 C CG . PHE A 1 501 ? 27.006 -8.500 26.463 1.00 32.87 ? 517 PHE A CG 1 ATOM 4129 C CD1 . PHE A 1 501 ? 27.181 -8.001 27.753 1.00 32.94 ? 517 PHE A CD1 1 ATOM 4130 C CD2 . PHE A 1 501 ? 27.255 -7.657 25.377 1.00 32.48 ? 517 PHE A CD2 1 ATOM 4131 C CE1 . PHE A 1 501 ? 27.608 -6.690 27.959 1.00 32.64 ? 517 PHE A CE1 1 ATOM 4132 C CE2 . PHE A 1 501 ? 27.676 -6.348 25.570 1.00 33.11 ? 517 PHE A CE2 1 ATOM 4133 C CZ . PHE A 1 501 ? 27.856 -5.861 26.865 1.00 33.60 ? 517 PHE A CZ 1 ATOM 4134 N N . TYR A 1 502 ? 26.886 -12.989 25.945 1.00 32.98 ? 518 TYR A N 1 ATOM 4135 C CA . TYR A 1 502 ? 26.332 -14.265 25.502 1.00 33.14 ? 518 TYR A CA 1 ATOM 4136 C C . TYR A 1 502 ? 26.421 -15.342 26.575 1.00 33.38 ? 518 TYR A C 1 ATOM 4137 O O . TYR A 1 502 ? 25.443 -16.041 26.835 1.00 33.48 ? 518 TYR A O 1 ATOM 4138 C CB . TYR A 1 502 ? 27.029 -14.741 24.223 1.00 32.96 ? 518 TYR A CB 1 ATOM 4139 C CG . TYR A 1 502 ? 26.478 -16.019 23.635 1.00 32.96 ? 518 TYR A CG 1 ATOM 4140 C CD1 . TYR A 1 502 ? 25.218 -16.053 23.037 1.00 33.60 ? 518 TYR A CD1 1 ATOM 4141 C CD2 . TYR A 1 502 ? 27.230 -17.189 23.647 1.00 33.52 ? 518 TYR A CD2 1 ATOM 4142 C CE1 . TYR A 1 502 ? 24.713 -17.230 22.481 1.00 34.02 ? 518 TYR A CE1 1 ATOM 4143 C CE2 . TYR A 1 502 ? 26.738 -18.366 23.092 1.00 34.47 ? 518 TYR A CE2 1 ATOM 4144 C CZ . TYR A 1 502 ? 25.480 -18.381 22.514 1.00 34.62 ? 518 TYR A CZ 1 ATOM 4145 O OH . TYR A 1 502 ? 25.009 -19.549 21.957 1.00 35.71 ? 518 TYR A OH 1 ATOM 4146 N N . LYS A 1 503 ? 27.595 -15.480 27.184 1.00 33.77 ? 519 LYS A N 1 ATOM 4147 C CA . LYS A 1 503 ? 27.791 -16.436 28.272 1.00 34.16 ? 519 LYS A CA 1 ATOM 4148 C C . LYS A 1 503 ? 26.819 -16.153 29.425 1.00 34.50 ? 519 LYS A C 1 ATOM 4149 O O . LYS A 1 503 ? 26.192 -17.072 29.958 1.00 34.68 ? 519 LYS A O 1 ATOM 4150 C CB . LYS A 1 503 ? 29.245 -16.408 28.758 1.00 34.01 ? 519 LYS A CB 1 ATOM 4151 C CG . LYS A 1 503 ? 29.533 -17.277 29.987 1.00 33.66 ? 519 LYS A CG 1 ATOM 4152 C CD . LYS A 1 503 ? 30.973 -17.122 30.458 1.00 33.16 ? 519 LYS A CD 1 ATOM 4153 C CE . LYS A 1 503 ? 31.111 -17.533 31.928 1.00 33.33 ? 519 LYS A CE 1 ATOM 4154 N NZ . LYS A 1 503 ? 32.534 -17.636 32.340 1.00 33.45 ? 519 LYS A NZ 1 ATOM 4155 N N . SER A 1 504 ? 26.690 -14.881 29.791 1.00 34.88 ? 520 SER A N 1 ATOM 4156 C CA . SER A 1 504 ? 25.813 -14.487 30.893 1.00 35.41 ? 520 SER A CA 1 ATOM 4157 C C . SER A 1 504 ? 24.329 -14.667 30.570 1.00 35.49 ? 520 SER A C 1 ATOM 4158 O O . SER A 1 504 ? 23.574 -15.147 31.413 1.00 35.70 ? 520 SER A O 1 ATOM 4159 C CB . SER A 1 504 ? 26.099 -13.054 31.329 1.00 35.32 ? 520 SER A CB 1 ATOM 4160 O OG . SER A 1 504 ? 27.381 -12.975 31.920 1.00 36.03 ? 520 SER A OG 1 ATOM 4161 N N . ALA A 1 505 ? 23.922 -14.292 29.355 1.00 35.65 ? 521 ALA A N 1 ATOM 4162 C CA . ALA A 1 505 ? 22.546 -14.496 28.901 1.00 35.74 ? 521 ALA A CA 1 ATOM 4163 C C . ALA A 1 505 ? 22.200 -15.984 28.873 1.00 35.92 ? 521 ALA A C 1 ATOM 4164 O O . ALA A 1 505 ? 21.114 -16.379 29.304 1.00 36.05 ? 521 ALA A O 1 ATOM 4165 C CB . ALA A 1 505 ? 22.322 -13.866 27.527 1.00 35.61 ? 521 ALA A CB 1 ATOM 4166 N N . CYS A 1 506 ? 23.138 -16.797 28.386 1.00 35.75 ? 522 CYS A N 1 ATOM 4167 C CA . CYS A 1 506 ? 22.969 -18.248 28.332 1.00 36.04 ? 522 CYS A CA 1 ATOM 4168 C C . CYS A 1 506 ? 22.849 -18.894 29.722 1.00 36.42 ? 522 CYS A C 1 ATOM 4169 O O . CYS A 1 506 ? 22.039 -19.801 29.912 1.00 36.31 ? 522 CYS A O 1 ATOM 4170 C CB . CYS A 1 506 ? 24.095 -18.895 27.519 1.00 35.94 ? 522 CYS A CB 1 ATOM 4171 S SG . CYS A 1 506 ? 24.036 -18.465 25.763 1.00 35.62 ? 522 CYS A SG 1 ATOM 4172 N N . ILE A 1 507 ? 23.648 -18.431 30.679 1.00 36.81 ? 523 ILE A N 1 ATOM 4173 C CA . ILE A 1 507 ? 23.518 -18.894 32.068 1.00 37.26 ? 523 ILE A CA 1 ATOM 4174 C C . ILE A 1 507 ? 22.128 -18.527 32.611 1.00 37.65 ? 523 ILE A C 1 ATOM 4175 O O . ILE A 1 507 ? 21.418 -19.385 33.134 1.00 37.75 ? 523 ILE A O 1 ATOM 4176 C CB . ILE A 1 507 ? 24.661 -18.370 32.981 1.00 37.07 ? 523 ILE A CB 1 ATOM 4177 C CG1 . ILE A 1 507 ? 25.978 -19.064 32.612 1.00 37.16 ? 523 ILE A CG1 1 ATOM 4178 C CG2 . ILE A 1 507 ? 24.333 -18.607 34.477 1.00 37.39 ? 523 ILE A CG2 1 ATOM 4179 C CD1 . ILE A 1 507 ? 27.242 -18.399 33.161 1.00 36.86 ? 523 ILE A CD1 1 ATOM 4180 N N . LYS A 1 508 ? 21.735 -17.267 32.432 1.00 38.07 ? 524 LYS A N 1 ATOM 4181 C CA . LYS A 1 508 ? 20.432 -16.772 32.885 1.00 38.72 ? 524 LYS A CA 1 ATOM 4182 C C . LYS A 1 508 ? 19.265 -17.511 32.230 1.00 39.00 ? 524 LYS A C 1 ATOM 4183 O O . LYS A 1 508 ? 18.207 -17.673 32.842 1.00 38.96 ? 524 LYS A O 1 ATOM 4184 C CB . LYS A 1 508 ? 20.302 -15.265 32.623 1.00 38.80 ? 524 LYS A CB 1 ATOM 4185 C CG . LYS A 1 508 ? 21.248 -14.392 33.441 1.00 38.89 ? 524 LYS A CG 1 ATOM 4186 C CD . LYS A 1 508 ? 21.268 -12.973 32.892 1.00 39.25 ? 524 LYS A CD 1 ATOM 4187 C CE . LYS A 1 508 ? 22.383 -12.152 33.505 1.00 39.74 ? 524 LYS A CE 1 ATOM 4188 N NZ . LYS A 1 508 ? 22.141 -11.874 34.946 1.00 40.77 ? 524 LYS A NZ 1 ATOM 4189 N N . ALA A 1 509 ? 19.466 -17.952 30.987 1.00 39.18 ? 525 ALA A N 1 ATOM 4190 C CA . ALA A 1 509 ? 18.453 -18.686 30.232 1.00 39.33 ? 525 ALA A CA 1 ATOM 4191 C C . ALA A 1 509 ? 18.370 -20.157 30.637 1.00 39.67 ? 525 ALA A C 1 ATOM 4192 O O . ALA A 1 509 ? 17.471 -20.872 30.196 1.00 39.78 ? 525 ALA A O 1 ATOM 4193 C CB . ALA A 1 509 ? 18.728 -18.569 28.729 1.00 39.25 ? 525 ALA A CB 1 ATOM 4194 N N . GLY A 1 510 ? 19.312 -20.605 31.464 1.00 39.88 ? 526 GLY A N 1 ATOM 4195 C CA . GLY A 1 510 ? 19.438 -22.021 31.808 1.00 40.50 ? 526 GLY A CA 1 ATOM 4196 C C . GLY A 1 510 ? 19.963 -22.841 30.640 1.00 40.94 ? 526 GLY A C 1 ATOM 4197 O O . GLY A 1 510 ? 19.808 -24.065 30.608 1.00 40.91 ? 526 GLY A O 1 ATOM 4198 N N . GLN A 1 511 ? 20.590 -22.158 29.682 1.00 41.11 ? 527 GLN A N 1 ATOM 4199 C CA . GLN A 1 511 ? 21.075 -22.779 28.451 1.00 41.62 ? 527 GLN A CA 1 ATOM 4200 C C . GLN A 1 511 ? 22.552 -23.177 28.497 1.00 42.05 ? 527 GLN A C 1 ATOM 4201 O O . GLN A 1 511 ? 23.053 -23.815 27.570 1.00 42.06 ? 527 GLN A O 1 ATOM 4202 C CB . GLN A 1 511 ? 20.836 -21.836 27.269 1.00 41.58 ? 527 GLN A CB 1 ATOM 4203 C CG . GLN A 1 511 ? 19.417 -21.848 26.752 1.00 41.88 ? 527 GLN A CG 1 ATOM 4204 C CD . GLN A 1 511 ? 19.124 -23.084 25.927 1.00 43.52 ? 527 GLN A CD 1 ATOM 4205 O OE1 . GLN A 1 511 ? 19.835 -23.383 24.957 1.00 44.28 ? 527 GLN A OE1 1 ATOM 4206 N NE2 . GLN A 1 511 ? 18.072 -23.806 26.297 1.00 42.03 ? 527 GLN A NE2 1 ATOM 4207 N N . TYR A 1 512 ? 23.250 -22.795 29.565 1.00 42.55 ? 528 TYR A N 1 ATOM 4208 C CA . TYR A 1 512 ? 24.667 -23.108 29.690 1.00 43.04 ? 528 TYR A CA 1 ATOM 4209 C C . TYR A 1 512 ? 25.099 -23.452 31.110 1.00 43.86 ? 528 TYR A C 1 ATOM 4210 O O . TYR A 1 512 ? 24.866 -22.696 32.055 1.00 43.76 ? 528 TYR A O 1 ATOM 4211 C CB . TYR A 1 512 ? 25.532 -21.976 29.124 1.00 42.77 ? 528 TYR A CB 1 ATOM 4212 C CG . TYR A 1 512 ? 27.019 -22.150 29.357 1.00 41.99 ? 528 TYR A CG 1 ATOM 4213 C CD1 . TYR A 1 512 ? 27.695 -23.273 28.875 1.00 41.12 ? 528 TYR A CD1 1 ATOM 4214 C CD2 . TYR A 1 512 ? 27.754 -21.184 30.047 1.00 40.55 ? 528 TYR A CD2 1 ATOM 4215 C CE1 . TYR A 1 512 ? 29.056 -23.435 29.084 1.00 40.83 ? 528 TYR A CE1 1 ATOM 4216 C CE2 . TYR A 1 512 ? 29.120 -21.334 30.254 1.00 40.08 ? 528 TYR A CE2 1 ATOM 4217 C CZ . TYR A 1 512 ? 29.763 -22.463 29.771 1.00 39.97 ? 528 TYR A CZ 1 ATOM 4218 O OH . TYR A 1 512 ? 31.112 -22.629 29.971 1.00 40.03 ? 528 TYR A OH 1 ATOM 4219 N N . ASP A 1 513 ? 25.742 -24.610 31.222 1.00 45.07 ? 529 ASP A N 1 ATOM 4220 C CA . ASP A 1 513 ? 26.345 -25.089 32.455 1.00 46.45 ? 529 ASP A CA 1 ATOM 4221 C C . ASP A 1 513 ? 27.662 -25.749 32.050 1.00 47.11 ? 529 ASP A C 1 ATOM 4222 O O . ASP A 1 513 ? 27.654 -26.713 31.275 1.00 47.22 ? 529 ASP A O 1 ATOM 4223 C CB . ASP A 1 513 ? 25.406 -26.097 33.141 1.00 46.53 ? 529 ASP A CB 1 ATOM 4224 C CG . ASP A 1 513 ? 25.884 -26.524 34.534 1.00 47.26 ? 529 ASP A CG 1 ATOM 4225 O OD1 . ASP A 1 513 ? 27.010 -26.183 34.955 1.00 47.36 ? 529 ASP A OD1 1 ATOM 4226 O OD2 . ASP A 1 513 ? 25.108 -27.220 35.219 1.00 48.73 ? 529 ASP A OD2 1 ATOM 4227 N N . PRO A 1 514 ? 28.801 -25.218 32.545 1.00 48.00 ? 530 PRO A N 1 ATOM 4228 C CA . PRO A 1 514 ? 30.121 -25.763 32.193 1.00 48.79 ? 530 PRO A CA 1 ATOM 4229 C C . PRO A 1 514 ? 30.334 -27.210 32.649 1.00 49.69 ? 530 PRO A C 1 ATOM 4230 O O . PRO A 1 514 ? 31.128 -27.933 32.047 1.00 49.80 ? 530 PRO A O 1 ATOM 4231 C CB . PRO A 1 514 ? 31.101 -24.825 32.916 1.00 48.60 ? 530 PRO A CB 1 ATOM 4232 C CG . PRO A 1 514 ? 30.296 -24.152 33.969 1.00 48.45 ? 530 PRO A CG 1 ATOM 4233 C CD . PRO A 1 514 ? 28.915 -24.030 33.411 1.00 48.06 ? 530 PRO A CD 1 ATOM 4234 N N . ASP A 1 515 ? 29.621 -27.619 33.696 1.00 50.67 ? 531 ASP A N 1 ATOM 4235 C CA . ASP A 1 515 ? 29.750 -28.966 34.252 1.00 51.63 ? 531 ASP A CA 1 ATOM 4236 C C . ASP A 1 515 ? 28.715 -29.947 33.683 1.00 51.95 ? 531 ASP A C 1 ATOM 4237 O O . ASP A 1 515 ? 28.602 -31.084 34.147 1.00 52.32 ? 531 ASP A O 1 ATOM 4238 C CB . ASP A 1 515 ? 29.677 -28.907 35.784 1.00 51.79 ? 531 ASP A CB 1 ATOM 4239 C CG . ASP A 1 515 ? 30.769 -28.027 36.391 1.00 52.57 ? 531 ASP A CG 1 ATOM 4240 O OD1 . ASP A 1 515 ? 31.922 -28.079 35.913 1.00 53.46 ? 531 ASP A OD1 1 ATOM 4241 O OD2 . ASP A 1 515 ? 30.477 -27.289 37.356 1.00 53.95 ? 531 ASP A OD2 1 ATOM 4242 N N . ASN A 1 516 ? 27.985 -29.508 32.661 1.00 52.22 ? 532 ASN A N 1 ATOM 4243 C CA . ASN A 1 516 ? 26.938 -30.314 32.043 1.00 52.23 ? 532 ASN A CA 1 ATOM 4244 C C . ASN A 1 516 ? 27.135 -30.426 30.531 1.00 52.18 ? 532 ASN A C 1 ATOM 4245 O O . ASN A 1 516 ? 27.015 -29.437 29.799 1.00 52.35 ? 532 ASN A O 1 ATOM 4246 C CB . ASN A 1 516 ? 25.561 -29.725 32.380 1.00 52.33 ? 532 ASN A CB 1 ATOM 4247 C CG . ASN A 1 516 ? 24.401 -30.587 31.889 1.00 52.72 ? 532 ASN A CG 1 ATOM 4248 O OD1 . ASN A 1 516 ? 24.576 -31.539 31.125 1.00 53.36 ? 532 ASN A OD1 1 ATOM 4249 N ND2 . ASN A 1 516 ? 23.197 -30.237 32.327 1.00 53.28 ? 532 ASN A ND2 1 ATOM 4250 N N . VAL A 1 517 ? 27.416 -31.647 30.079 1.00 51.94 ? 533 VAL A N 1 ATOM 4251 C CA . VAL A 1 517 ? 27.701 -31.947 28.669 1.00 51.62 ? 533 VAL A CA 1 ATOM 4252 C C . VAL A 1 517 ? 26.505 -31.694 27.734 1.00 51.29 ? 533 VAL A C 1 ATOM 4253 O O . VAL A 1 517 ? 26.673 -31.564 26.519 1.00 51.42 ? 533 VAL A O 1 ATOM 4254 C CB . VAL A 1 517 ? 28.250 -33.406 28.509 1.00 51.75 ? 533 VAL A CB 1 ATOM 4255 C CG1 . VAL A 1 517 ? 27.188 -34.446 28.880 1.00 51.87 ? 533 VAL A CG1 1 ATOM 4256 C CG2 . VAL A 1 517 ? 28.792 -33.653 27.098 1.00 51.93 ? 533 VAL A CG2 1 ATOM 4257 N N . GLU A 1 518 ? 25.304 -31.626 28.301 1.00 50.75 ? 534 GLU A N 1 ATOM 4258 C CA . GLU A 1 518 ? 24.092 -31.419 27.508 1.00 50.35 ? 534 GLU A CA 1 ATOM 4259 C C . GLU A 1 518 ? 23.819 -29.940 27.239 1.00 49.25 ? 534 GLU A C 1 ATOM 4260 O O . GLU A 1 518 ? 22.968 -29.602 26.413 1.00 49.26 ? 534 GLU A O 1 ATOM 4261 C CB . GLU A 1 518 ? 22.869 -32.070 28.180 1.00 50.80 ? 534 GLU A CB 1 ATOM 4262 C CG . GLU A 1 518 ? 22.971 -33.588 28.418 1.00 52.77 ? 534 GLU A CG 1 ATOM 4263 C CD . GLU A 1 518 ? 23.244 -34.403 27.148 1.00 55.70 ? 534 GLU A CD 1 ATOM 4264 O OE1 . GLU A 1 518 ? 22.829 -33.990 26.036 1.00 56.60 ? 534 GLU A OE1 1 ATOM 4265 O OE2 . GLU A 1 518 ? 23.874 -35.479 27.270 1.00 57.47 ? 534 GLU A OE2 1 ATOM 4266 N N . LEU A 1 519 ? 24.547 -29.066 27.935 1.00 47.93 ? 535 LEU A N 1 ATOM 4267 C CA . LEU A 1 519 ? 24.362 -27.619 27.799 1.00 46.60 ? 535 LEU A CA 1 ATOM 4268 C C . LEU A 1 519 ? 25.669 -26.884 27.454 1.00 45.26 ? 535 LEU A C 1 ATOM 4269 O O . LEU A 1 519 ? 26.167 -26.099 28.264 1.00 44.86 ? 535 LEU A O 1 ATOM 4270 C CB . LEU A 1 519 ? 23.743 -27.037 29.082 1.00 46.71 ? 535 LEU A CB 1 ATOM 4271 C CG . LEU A 1 519 ? 22.422 -27.617 29.610 1.00 47.06 ? 535 LEU A CG 1 ATOM 4272 C CD1 . LEU A 1 519 ? 22.163 -27.154 31.046 1.00 46.64 ? 535 LEU A CD1 1 ATOM 4273 C CD2 . LEU A 1 519 ? 21.248 -27.271 28.699 1.00 46.82 ? 535 LEU A CD2 1 ATOM 4274 N N . PRO A 1 520 ? 26.225 -27.132 26.249 1.00 44.00 ? 536 PRO A N 1 ATOM 4275 C CA . PRO A 1 520 ? 27.462 -26.436 25.883 1.00 43.05 ? 536 PRO A CA 1 ATOM 4276 C C . PRO A 1 520 ? 27.198 -24.987 25.461 1.00 41.88 ? 536 PRO A C 1 ATOM 4277 O O . PRO A 1 520 ? 26.145 -24.688 24.882 1.00 41.57 ? 536 PRO A O 1 ATOM 4278 C CB . PRO A 1 520 ? 27.983 -27.256 24.697 1.00 43.11 ? 536 PRO A CB 1 ATOM 4279 C CG . PRO A 1 520 ? 26.755 -27.813 24.057 1.00 43.42 ? 536 PRO A CG 1 ATOM 4280 C CD . PRO A 1 520 ? 25.734 -27.995 25.155 1.00 43.95 ? 536 PRO A CD 1 ATOM 4281 N N . LEU A 1 521 ? 28.149 -24.100 25.743 1.00 40.69 ? 537 LEU A N 1 ATOM 4282 C CA . LEU A 1 521 ? 28.013 -22.692 25.370 1.00 39.60 ? 537 LEU A CA 1 ATOM 4283 C C . LEU A 1 521 ? 27.781 -22.518 23.866 1.00 39.00 ? 537 LEU A C 1 ATOM 4284 O O . LEU A 1 521 ? 26.987 -21.670 23.453 1.00 38.55 ? 537 LEU A O 1 ATOM 4285 C CB . LEU A 1 521 ? 29.229 -21.880 25.828 1.00 39.45 ? 537 LEU A CB 1 ATOM 4286 C CG . LEU A 1 521 ? 29.159 -20.350 25.738 1.00 39.33 ? 537 LEU A CG 1 ATOM 4287 C CD1 . LEU A 1 521 ? 27.845 -19.795 26.298 1.00 38.90 ? 537 LEU A CD1 1 ATOM 4288 C CD2 . LEU A 1 521 ? 30.349 -19.727 26.454 1.00 38.97 ? 537 LEU A CD2 1 ATOM 4289 N N . ASP A 1 522 ? 28.453 -23.344 23.067 1.00 38.38 ? 538 ASP A N 1 ATOM 4290 C CA . ASP A 1 522 ? 28.365 -23.264 21.607 1.00 37.93 ? 538 ASP A CA 1 ATOM 4291 C C . ASP A 1 522 ? 27.049 -23.784 21.002 1.00 38.03 ? 538 ASP A C 1 ATOM 4292 O O . ASP A 1 522 ? 26.859 -23.719 19.787 1.00 37.94 ? 538 ASP A O 1 ATOM 4293 C CB . ASP A 1 522 ? 29.583 -23.923 20.943 1.00 37.76 ? 538 ASP A CB 1 ATOM 4294 C CG . ASP A 1 522 ? 29.877 -25.319 21.482 1.00 37.21 ? 538 ASP A CG 1 ATOM 4295 O OD1 . ASP A 1 522 ? 30.292 -25.448 22.657 1.00 36.55 ? 538 ASP A OD1 1 ATOM 4296 O OD2 . ASP A 1 522 ? 29.718 -26.286 20.713 1.00 35.72 ? 538 ASP A OD2 1 ATOM 4297 N N . ASN A 1 523 ? 26.146 -24.305 21.834 1.00 37.78 ? 539 ASN A N 1 ATOM 4298 C CA . ASN A 1 523 ? 24.810 -24.659 21.350 1.00 37.67 ? 539 ASN A CA 1 ATOM 4299 C C . ASN A 1 523 ? 23.674 -23.983 22.133 1.00 37.49 ? 539 ASN A C 1 ATOM 4300 O O . ASN A 1 523 ? 22.549 -24.491 22.191 1.00 37.59 ? 539 ASN A O 1 ATOM 4301 C CB . ASN A 1 523 ? 24.617 -26.179 21.284 1.00 37.53 ? 539 ASN A CB 1 ATOM 4302 C CG . ASN A 1 523 ? 23.598 -26.591 20.233 1.00 37.62 ? 539 ASN A CG 1 ATOM 4303 O OD1 . ASN A 1 523 ? 23.437 -25.922 19.206 1.00 38.49 ? 539 ASN A OD1 1 ATOM 4304 N ND2 . ASN A 1 523 ? 22.902 -27.699 20.482 1.00 36.61 ? 539 ASN A ND2 1 ATOM 4305 N N . CYS A 1 524 ? 23.973 -22.824 22.714 1.00 37.22 ? 540 CYS A N 1 ATOM 4306 C CA . CYS A 1 524 ? 22.990 -22.078 23.501 1.00 36.84 ? 540 CYS A CA 1 ATOM 4307 C C . CYS A 1 524 ? 22.052 -21.229 22.643 1.00 36.61 ? 540 CYS A C 1 ATOM 4308 O O . CYS A 1 524 ? 22.497 -20.412 21.835 1.00 36.55 ? 540 CYS A O 1 ATOM 4309 C CB . CYS A 1 524 ? 23.683 -21.192 24.539 1.00 36.72 ? 540 CYS A CB 1 ATOM 4310 S SG . CYS A 1 524 ? 22.684 -19.770 25.007 1.00 36.57 ? 540 CYS A SG 1 ATOM 4311 N N . ASP A 1 525 ? 20.750 -21.422 22.841 1.00 36.35 ? 541 ASP A N 1 ATOM 4312 C CA . ASP A 1 525 ? 19.743 -20.577 22.208 1.00 36.13 ? 541 ASP A CA 1 ATOM 4313 C C . ASP A 1 525 ? 18.985 -19.775 23.267 1.00 36.13 ? 541 ASP A C 1 ATOM 4314 O O . ASP A 1 525 ? 18.310 -20.352 24.119 1.00 36.01 ? 541 ASP A O 1 ATOM 4315 C CB . ASP A 1 525 ? 18.768 -21.426 21.388 1.00 35.99 ? 541 ASP A CB 1 ATOM 4316 C CG . ASP A 1 525 ? 17.840 -20.590 20.526 1.00 35.86 ? 541 ASP A CG 1 ATOM 4317 O OD1 . ASP A 1 525 ? 18.031 -19.357 20.433 1.00 34.79 ? 541 ASP A OD1 1 ATOM 4318 O OD2 . ASP A 1 525 ? 16.911 -21.174 19.932 1.00 35.89 ? 541 ASP A OD2 1 ATOM 4319 N N . ILE A 1 526 ? 19.094 -18.450 23.203 1.00 36.14 ? 542 ILE A N 1 ATOM 4320 C CA . ILE A 1 526 ? 18.396 -17.583 24.158 1.00 36.18 ? 542 ILE A CA 1 ATOM 4321 C C . ILE A 1 526 ? 17.022 -17.126 23.664 1.00 36.50 ? 542 ILE A C 1 ATOM 4322 O O . ILE A 1 526 ? 16.371 -16.310 24.319 1.00 36.10 ? 542 ILE A O 1 ATOM 4323 C CB . ILE A 1 526 ? 19.251 -16.357 24.613 1.00 36.09 ? 542 ILE A CB 1 ATOM 4324 C CG1 . ILE A 1 526 ? 19.596 -15.442 23.421 1.00 35.86 ? 542 ILE A CG1 1 ATOM 4325 C CG2 . ILE A 1 526 ? 20.473 -16.824 25.399 1.00 35.39 ? 542 ILE A CG2 1 ATOM 4326 C CD1 . ILE A 1 526 ? 20.298 -14.140 23.796 1.00 35.41 ? 542 ILE A CD1 1 ATOM 4327 N N . TYR A 1 527 ? 16.584 -17.657 22.518 1.00 36.86 ? 543 TYR A N 1 ATOM 4328 C CA . TYR A 1 527 ? 15.231 -17.389 22.027 1.00 37.30 ? 543 TYR A CA 1 ATOM 4329 C C . TYR A 1 527 ? 14.213 -17.727 23.110 1.00 37.39 ? 543 TYR A C 1 ATOM 4330 O O . TYR A 1 527 ? 14.306 -18.770 23.749 1.00 37.55 ? 543 TYR A O 1 ATOM 4331 C CB . TYR A 1 527 ? 14.915 -18.177 20.748 1.00 37.36 ? 543 TYR A CB 1 ATOM 4332 C CG . TYR A 1 527 ? 13.533 -17.884 20.200 1.00 38.08 ? 543 TYR A CG 1 ATOM 4333 C CD1 . TYR A 1 527 ? 13.326 -16.832 19.315 1.00 39.50 ? 543 TYR A CD1 1 ATOM 4334 C CD2 . TYR A 1 527 ? 12.427 -18.651 20.580 1.00 39.45 ? 543 TYR A CD2 1 ATOM 4335 C CE1 . TYR A 1 527 ? 12.060 -16.547 18.813 1.00 40.22 ? 543 TYR A CE1 1 ATOM 4336 C CE2 . TYR A 1 527 ? 11.150 -18.369 20.088 1.00 39.71 ? 543 TYR A CE2 1 ATOM 4337 C CZ . TYR A 1 527 ? 10.978 -17.317 19.205 1.00 40.82 ? 543 TYR A CZ 1 ATOM 4338 O OH . TYR A 1 527 ? 9.729 -17.024 18.702 1.00 41.83 ? 543 TYR A OH 1 ATOM 4339 N N . GLY A 1 528 ? 13.261 -16.823 23.322 1.00 37.69 ? 544 GLY A N 1 ATOM 4340 C CA . GLY A 1 528 ? 12.191 -17.043 24.292 1.00 37.90 ? 544 GLY A CA 1 ATOM 4341 C C . GLY A 1 528 ? 12.547 -16.757 25.742 1.00 38.12 ? 544 GLY A C 1 ATOM 4342 O O . GLY A 1 528 ? 11.678 -16.821 26.613 1.00 38.36 ? 544 GLY A O 1 ATOM 4343 N N . SER A 1 529 ? 13.808 -16.430 26.014 1.00 37.93 ? 545 SER A N 1 ATOM 4344 C CA . SER A 1 529 ? 14.248 -16.233 27.400 1.00 38.01 ? 545 SER A CA 1 ATOM 4345 C C . SER A 1 529 ? 13.965 -14.819 27.909 1.00 38.03 ? 545 SER A C 1 ATOM 4346 O O . SER A 1 529 ? 14.611 -13.851 27.495 1.00 37.80 ? 545 SER A O 1 ATOM 4347 C CB . SER A 1 529 ? 15.731 -16.594 27.572 1.00 37.95 ? 545 SER A CB 1 ATOM 4348 O OG . SER A 1 529 ? 16.184 -16.299 28.890 1.00 37.99 ? 545 SER A OG 1 ATOM 4349 N N . ALA A 1 530 ? 12.990 -14.713 28.809 1.00 37.95 ? 546 ALA A N 1 ATOM 4350 C CA . ALA A 1 530 ? 12.659 -13.442 29.446 1.00 37.90 ? 546 ALA A CA 1 ATOM 4351 C C . ALA A 1 530 ? 13.772 -12.996 30.388 1.00 37.73 ? 546 ALA A C 1 ATOM 4352 O O . ALA A 1 530 ? 13.998 -11.798 30.551 1.00 37.77 ? 546 ALA A O 1 ATOM 4353 C CB . ALA A 1 530 ? 11.331 -13.546 30.203 1.00 38.24 ? 546 ALA A CB 1 ATOM 4354 N N . ALA A 1 531 ? 14.455 -13.961 31.004 1.00 37.70 ? 547 ALA A N 1 ATOM 4355 C CA . ALA A 1 531 ? 15.563 -13.676 31.924 1.00 37.64 ? 547 ALA A CA 1 ATOM 4356 C C . ALA A 1 531 ? 16.767 -13.057 31.208 1.00 37.49 ? 547 ALA A C 1 ATOM 4357 O O . ALA A 1 531 ? 17.396 -12.136 31.731 1.00 37.49 ? 547 ALA A O 1 ATOM 4358 C CB . ALA A 1 531 ? 15.975 -14.927 32.683 1.00 37.64 ? 547 ALA A CB 1 ATOM 4359 N N . ALA A 1 532 ? 17.076 -13.556 30.012 1.00 37.09 ? 548 ALA A N 1 ATOM 4360 C CA . ALA A 1 532 ? 18.104 -12.937 29.173 1.00 36.90 ? 548 ALA A CA 1 ATOM 4361 C C . ALA A 1 532 ? 17.668 -11.537 28.746 1.00 36.60 ? 548 ALA A C 1 ATOM 4362 O O . ALA A 1 532 ? 18.458 -10.595 28.789 1.00 36.85 ? 548 ALA A O 1 ATOM 4363 C CB . ALA A 1 532 ? 18.410 -13.809 27.955 1.00 36.64 ? 548 ALA A CB 1 ATOM 4364 N N . GLY A 1 533 ? 16.402 -11.408 28.350 1.00 36.41 ? 549 GLY A N 1 ATOM 4365 C CA . GLY A 1 533 ? 15.822 -10.113 27.980 1.00 36.01 ? 549 GLY A CA 1 ATOM 4366 C C . GLY A 1 533 ? 15.868 -9.075 29.093 1.00 35.76 ? 549 GLY A C 1 ATOM 4367 O O . GLY A 1 533 ? 16.115 -7.890 28.836 1.00 35.46 ? 549 GLY A O 1 ATOM 4368 N N . ALA A 1 534 ? 15.629 -9.523 30.327 1.00 35.37 ? 550 ALA A N 1 ATOM 4369 C CA . ALA A 1 534 ? 15.694 -8.658 31.509 1.00 35.40 ? 550 ALA A CA 1 ATOM 4370 C C . ALA A 1 534 ? 17.073 -8.025 31.670 1.00 35.31 ? 550 ALA A C 1 ATOM 4371 O O . ALA A 1 534 ? 17.184 -6.843 32.004 1.00 35.55 ? 550 ALA A O 1 ATOM 4372 C CB . ALA A 1 534 ? 15.310 -9.443 32.778 1.00 35.26 ? 550 ALA A CB 1 ATOM 4373 N N . ALA A 1 535 ? 18.118 -8.814 31.424 1.00 35.36 ? 551 ALA A N 1 ATOM 4374 C CA . ALA A 1 535 ? 19.496 -8.329 31.494 1.00 35.41 ? 551 ALA A CA 1 ATOM 4375 C C . ALA A 1 535 ? 19.760 -7.259 30.431 1.00 35.43 ? 551 ALA A C 1 ATOM 4376 O O . ALA A 1 535 ? 20.340 -6.213 30.735 1.00 35.23 ? 551 ALA A O 1 ATOM 4377 C CB . ALA A 1 535 ? 20.478 -9.483 31.358 1.00 35.37 ? 551 ALA A CB 1 ATOM 4378 N N . PHE A 1 536 ? 19.321 -7.520 29.197 1.00 35.40 ? 552 PHE A N 1 ATOM 4379 C CA . PHE A 1 536 ? 19.412 -6.528 28.130 1.00 35.59 ? 552 PHE A CA 1 ATOM 4380 C C . PHE A 1 536 ? 18.653 -5.248 28.469 1.00 35.48 ? 552 PHE A C 1 ATOM 4381 O O . PHE A 1 536 ? 19.189 -4.157 28.317 1.00 35.48 ? 552 PHE A O 1 ATOM 4382 C CB . PHE A 1 536 ? 18.948 -7.100 26.783 1.00 35.90 ? 552 PHE A CB 1 ATOM 4383 C CG . PHE A 1 536 ? 20.011 -7.886 26.073 1.00 36.81 ? 552 PHE A CG 1 ATOM 4384 C CD1 . PHE A 1 536 ? 21.041 -7.234 25.396 1.00 38.29 ? 552 PHE A CD1 1 ATOM 4385 C CD2 . PHE A 1 536 ? 20.006 -9.275 26.111 1.00 37.26 ? 552 PHE A CD2 1 ATOM 4386 C CE1 . PHE A 1 536 ? 22.045 -7.959 24.744 1.00 38.58 ? 552 PHE A CE1 1 ATOM 4387 C CE2 . PHE A 1 536 ? 21.003 -10.010 25.464 1.00 38.76 ? 552 PHE A CE2 1 ATOM 4388 C CZ . PHE A 1 536 ? 22.022 -9.347 24.777 1.00 38.67 ? 552 PHE A CZ 1 ATOM 4389 N N . HIS A 1 537 ? 17.419 -5.377 28.948 1.00 35.38 ? 553 HIS A N 1 ATOM 4390 C CA . HIS A 1 537 ? 16.659 -4.191 29.337 1.00 35.25 ? 553 HIS A CA 1 ATOM 4391 C C . HIS A 1 537 ? 17.412 -3.346 30.377 1.00 35.04 ? 553 HIS A C 1 ATOM 4392 O O . HIS A 1 537 ? 17.544 -2.134 30.212 1.00 34.91 ? 553 HIS A O 1 ATOM 4393 C CB . HIS A 1 537 ? 15.249 -4.539 29.838 1.00 35.22 ? 553 HIS A CB 1 ATOM 4394 C CG . HIS A 1 537 ? 14.518 -3.362 30.408 1.00 35.81 ? 553 HIS A CG 1 ATOM 4395 N ND1 . HIS A 1 537 ? 14.116 -2.293 29.635 1.00 35.61 ? 553 HIS A ND1 1 ATOM 4396 C CD2 . HIS A 1 537 ? 14.156 -3.064 31.679 1.00 36.19 ? 553 HIS A CD2 1 ATOM 4397 C CE1 . HIS A 1 537 ? 13.517 -1.399 30.402 1.00 36.88 ? 553 HIS A CE1 1 ATOM 4398 N NE2 . HIS A 1 537 ? 13.530 -1.842 31.646 1.00 36.66 ? 553 HIS A NE2 1 ATOM 4399 N N . ASN A 1 538 ? 17.914 -3.988 31.431 1.00 34.94 ? 554 ASN A N 1 ATOM 4400 C CA . ASN A 1 538 ? 18.643 -3.272 32.483 1.00 34.97 ? 554 ASN A CA 1 ATOM 4401 C C . ASN A 1 538 ? 19.842 -2.490 31.942 1.00 34.62 ? 554 ASN A C 1 ATOM 4402 O O . ASN A 1 538 ? 20.058 -1.338 32.312 1.00 34.48 ? 554 ASN A O 1 ATOM 4403 C CB . ASN A 1 538 ? 19.087 -4.231 33.597 1.00 35.24 ? 554 ASN A CB 1 ATOM 4404 C CG . ASN A 1 538 ? 17.911 -4.867 34.324 1.00 36.52 ? 554 ASN A CG 1 ATOM 4405 O OD1 . ASN A 1 538 ? 16.863 -4.244 34.506 1.00 38.62 ? 554 ASN A OD1 1 ATOM 4406 N ND2 . ASN A 1 538 ? 18.077 -6.120 34.732 1.00 37.40 ? 554 ASN A ND2 1 ATOM 4407 N N . MET A 1 539 ? 20.593 -3.112 31.036 1.00 34.05 ? 555 MET A N 1 ATOM 4408 C CA . MET A 1 539 ? 21.787 -2.493 30.477 1.00 33.49 ? 555 MET A CA 1 ATOM 4409 C C . MET A 1 539 ? 21.458 -1.458 29.398 1.00 33.19 ? 555 MET A C 1 ATOM 4410 O O . MET A 1 539 ? 21.933 -0.322 29.462 1.00 32.93 ? 555 MET A O 1 ATOM 4411 C CB . MET A 1 539 ? 22.736 -3.564 29.930 1.00 33.35 ? 555 MET A CB 1 ATOM 4412 C CG . MET A 1 539 ? 23.983 -3.001 29.256 1.00 33.56 ? 555 MET A CG 1 ATOM 4413 S SD . MET A 1 539 ? 25.109 -4.294 28.735 1.00 33.30 ? 555 MET A SD 1 ATOM 4414 C CE . MET A 1 539 ? 24.292 -4.881 27.252 1.00 34.08 ? 555 MET A CE 1 ATOM 4415 N N . LEU A 1 540 ? 20.655 -1.855 28.411 1.00 32.80 ? 556 LEU A N 1 ATOM 4416 C CA . LEU A 1 540 ? 20.353 -0.983 27.267 1.00 32.65 ? 556 LEU A CA 1 ATOM 4417 C C . LEU A 1 540 ? 19.570 0.282 27.629 1.00 32.44 ? 556 LEU A C 1 ATOM 4418 O O . LEU A 1 540 ? 19.783 1.342 27.036 1.00 32.38 ? 556 LEU A O 1 ATOM 4419 C CB . LEU A 1 540 ? 19.631 -1.758 26.153 1.00 32.63 ? 556 LEU A CB 1 ATOM 4420 C CG . LEU A 1 540 ? 20.271 -3.045 25.605 1.00 32.76 ? 556 LEU A CG 1 ATOM 4421 C CD1 . LEU A 1 540 ? 19.488 -3.567 24.397 1.00 33.41 ? 556 LEU A CD1 1 ATOM 4422 C CD2 . LEU A 1 540 ? 21.724 -2.825 25.230 1.00 32.41 ? 556 LEU A CD2 1 ATOM 4423 N N . SER A 1 541 ? 18.675 0.176 28.606 1.00 32.39 ? 557 SER A N 1 ATOM 4424 C CA . SER A 1 541 ? 17.847 1.317 28.991 1.00 32.38 ? 557 SER A CA 1 ATOM 4425 C C . SER A 1 541 ? 18.691 2.469 29.539 1.00 32.12 ? 557 SER A C 1 ATOM 4426 O O . SER A 1 541 ? 18.266 3.624 29.499 1.00 32.15 ? 557 SER A O 1 ATOM 4427 C CB . SER A 1 541 ? 16.748 0.907 29.983 1.00 32.44 ? 557 SER A CB 1 ATOM 4428 O OG . SER A 1 541 ? 17.301 0.381 31.177 1.00 32.55 ? 557 SER A OG 1 ATOM 4429 N N . MET A 1 542 ? 19.896 2.147 30.010 1.00 32.18 ? 558 MET A N 1 ATOM 4430 C CA . MET A 1 542 ? 20.815 3.136 30.587 1.00 32.00 ? 558 MET A CA 1 ATOM 4431 C C . MET A 1 542 ? 21.423 4.084 29.558 1.00 31.78 ? 558 MET A C 1 ATOM 4432 O O . MET A 1 542 ? 21.818 5.200 29.900 1.00 31.72 ? 558 MET A O 1 ATOM 4433 C CB . MET A 1 542 ? 21.940 2.436 31.350 1.00 32.13 ? 558 MET A CB 1 ATOM 4434 C CG . MET A 1 542 ? 21.496 1.666 32.581 1.00 32.31 ? 558 MET A CG 1 ATOM 4435 S SD . MET A 1 542 ? 22.853 0.720 33.298 1.00 34.81 ? 558 MET A SD 1 ATOM 4436 C CE . MET A 1 542 ? 23.977 2.038 33.754 1.00 32.39 ? 558 MET A CE 1 ATOM 4437 N N . GLY A 1 543 ? 21.504 3.649 28.300 1.00 31.64 ? 559 GLY A N 1 ATOM 4438 C CA . GLY A 1 543 ? 22.192 4.433 27.273 1.00 30.85 ? 559 GLY A CA 1 ATOM 4439 C C . GLY A 1 543 ? 23.605 4.783 27.725 1.00 30.67 ? 559 GLY A C 1 ATOM 4440 O O . GLY A 1 543 ? 24.336 3.924 28.225 1.00 30.25 ? 559 GLY A O 1 ATOM 4441 N N . ALA A 1 544 ? 23.976 6.053 27.585 1.00 30.48 ? 560 ALA A N 1 ATOM 4442 C CA . ALA A 1 544 ? 25.294 6.512 28.002 1.00 30.94 ? 560 ALA A CA 1 ATOM 4443 C C . ALA A 1 544 ? 25.232 7.288 29.316 1.00 31.42 ? 560 ALA A C 1 ATOM 4444 O O . ALA A 1 544 ? 26.105 8.118 29.591 1.00 31.74 ? 560 ALA A O 1 ATOM 4445 C CB . ALA A 1 544 ? 25.942 7.358 26.905 1.00 30.55 ? 560 ALA A CB 1 ATOM 4446 N N . SER A 1 545 ? 24.207 7.008 30.123 1.00 31.87 ? 561 SER A N 1 ATOM 4447 C CA . SER A 1 545 ? 23.949 7.753 31.363 1.00 32.18 ? 561 SER A CA 1 ATOM 4448 C C . SER A 1 545 ? 25.013 7.522 32.432 1.00 32.63 ? 561 SER A C 1 ATOM 4449 O O . SER A 1 545 ? 25.226 8.371 33.302 1.00 32.79 ? 561 SER A O 1 ATOM 4450 C CB . SER A 1 545 ? 22.546 7.441 31.918 1.00 32.04 ? 561 SER A CB 1 ATOM 4451 O OG . SER A 1 545 ? 22.398 6.073 32.272 1.00 30.75 ? 561 SER A OG 1 ATOM 4452 N N . LYS A 1 546 ? 25.664 6.367 32.362 1.00 33.13 ? 562 LYS A N 1 ATOM 4453 C CA . LYS A 1 546 ? 26.749 6.010 33.271 1.00 33.86 ? 562 LYS A CA 1 ATOM 4454 C C . LYS A 1 546 ? 27.953 5.523 32.455 1.00 33.67 ? 562 LYS A C 1 ATOM 4455 O O . LYS A 1 546 ? 27.777 5.089 31.315 1.00 33.47 ? 562 LYS A O 1 ATOM 4456 C CB . LYS A 1 546 ? 26.284 4.921 34.248 1.00 34.15 ? 562 LYS A CB 1 ATOM 4457 C CG . LYS A 1 546 ? 25.176 5.349 35.226 1.00 35.85 ? 562 LYS A CG 1 ATOM 4458 C CD . LYS A 1 546 ? 25.743 5.918 36.532 1.00 39.56 ? 562 LYS A CD 1 ATOM 4459 C CE . LYS A 1 546 ? 24.633 6.080 37.580 1.00 42.56 ? 562 LYS A CE 1 ATOM 4460 N NZ . LYS A 1 546 ? 25.154 6.291 38.977 1.00 44.40 ? 562 LYS A NZ 1 ATOM 4461 N N . PRO A 1 547 ? 29.180 5.600 33.027 1.00 33.65 ? 563 PRO A N 1 ATOM 4462 C CA . PRO A 1 547 ? 30.342 4.990 32.364 1.00 33.39 ? 563 PRO A CA 1 ATOM 4463 C C . PRO A 1 547 ? 30.085 3.506 32.090 1.00 33.02 ? 563 PRO A C 1 ATOM 4464 O O . PRO A 1 547 ? 29.377 2.855 32.864 1.00 32.88 ? 563 PRO A O 1 ATOM 4465 C CB . PRO A 1 547 ? 31.465 5.149 33.399 1.00 33.53 ? 563 PRO A CB 1 ATOM 4466 C CG . PRO A 1 547 ? 31.043 6.313 34.244 1.00 33.91 ? 563 PRO A CG 1 ATOM 4467 C CD . PRO A 1 547 ? 29.546 6.228 34.312 1.00 33.48 ? 563 PRO A CD 1 ATOM 4468 N N . TRP A 1 548 ? 30.665 2.979 31.009 1.00 32.60 ? 564 TRP A N 1 ATOM 4469 C CA . TRP A 1 548 ? 30.327 1.636 30.521 1.00 31.96 ? 564 TRP A CA 1 ATOM 4470 C C . TRP A 1 548 ? 30.522 0.469 31.515 1.00 31.88 ? 564 TRP A C 1 ATOM 4471 O O . TRP A 1 548 ? 29.803 -0.523 31.424 1.00 31.77 ? 564 TRP A O 1 ATOM 4472 C CB . TRP A 1 548 ? 30.997 1.350 29.163 1.00 31.70 ? 564 TRP A CB 1 ATOM 4473 C CG . TRP A 1 548 ? 32.484 1.233 29.221 1.00 30.37 ? 564 TRP A CG 1 ATOM 4474 C CD1 . TRP A 1 548 ? 33.393 2.211 28.948 1.00 29.33 ? 564 TRP A CD1 1 ATOM 4475 C CD2 . TRP A 1 548 ? 33.241 0.071 29.582 1.00 29.25 ? 564 TRP A CD2 1 ATOM 4476 N NE1 . TRP A 1 548 ? 34.667 1.737 29.120 1.00 29.71 ? 564 TRP A NE1 1 ATOM 4477 C CE2 . TRP A 1 548 ? 34.605 0.425 29.508 1.00 29.28 ? 564 TRP A CE2 1 ATOM 4478 C CE3 . TRP A 1 548 ? 32.899 -1.231 29.970 1.00 29.21 ? 564 TRP A CE3 1 ATOM 4479 C CZ2 . TRP A 1 548 ? 35.632 -0.478 29.800 1.00 29.57 ? 564 TRP A CZ2 1 ATOM 4480 C CZ3 . TRP A 1 548 ? 33.919 -2.132 30.259 1.00 30.16 ? 564 TRP A CZ3 1 ATOM 4481 C CH2 . TRP A 1 548 ? 35.272 -1.749 30.172 1.00 29.67 ? 564 TRP A CH2 1 ATOM 4482 N N . PRO A 1 549 ? 31.488 0.568 32.458 1.00 31.95 ? 565 PRO A N 1 ATOM 4483 C CA . PRO A 1 549 ? 31.549 -0.509 33.457 1.00 31.94 ? 565 PRO A CA 1 ATOM 4484 C C . PRO A 1 549 ? 30.265 -0.660 34.283 1.00 31.80 ? 565 PRO A C 1 ATOM 4485 O O . PRO A 1 549 ? 29.959 -1.765 34.736 1.00 31.68 ? 565 PRO A O 1 ATOM 4486 C CB . PRO A 1 549 ? 32.710 -0.086 34.364 1.00 32.00 ? 565 PRO A CB 1 ATOM 4487 C CG . PRO A 1 549 ? 33.575 0.755 33.503 1.00 32.14 ? 565 PRO A CG 1 ATOM 4488 C CD . PRO A 1 549 ? 32.653 1.472 32.561 1.00 31.98 ? 565 PRO A CD 1 ATOM 4489 N N . ASP A 1 550 ? 29.539 0.440 34.479 1.00 31.83 ? 566 ASP A N 1 ATOM 4490 C CA . ASP A 1 550 ? 28.246 0.416 35.173 1.00 31.96 ? 566 ASP A CA 1 ATOM 4491 C C . ASP A 1 550 ? 27.153 -0.239 34.331 1.00 31.92 ? 566 ASP A C 1 ATOM 4492 O O . ASP A 1 550 ? 26.215 -0.831 34.869 1.00 31.70 ? 566 ASP A O 1 ATOM 4493 C CB . ASP A 1 550 ? 27.815 1.832 35.554 1.00 32.25 ? 566 ASP A CB 1 ATOM 4494 C CG . ASP A 1 550 ? 28.722 2.465 36.602 1.00 33.47 ? 566 ASP A CG 1 ATOM 4495 O OD1 . ASP A 1 550 ? 29.357 1.730 37.376 1.00 35.44 ? 566 ASP A OD1 1 ATOM 4496 O OD2 . ASP A 1 550 ? 28.798 3.702 36.654 1.00 35.69 ? 566 ASP A OD2 1 ATOM 4497 N N . ALA A 1 551 ? 27.273 -0.124 33.008 1.00 31.63 ? 567 ALA A N 1 ATOM 4498 C CA . ALA A 1 551 ? 26.310 -0.727 32.095 1.00 31.75 ? 567 ALA A CA 1 ATOM 4499 C C . ALA A 1 551 ? 26.517 -2.235 32.012 1.00 31.98 ? 567 ALA A C 1 ATOM 4500 O O . ALA A 1 551 ? 25.550 -2.999 31.987 1.00 32.10 ? 567 ALA A O 1 ATOM 4501 C CB . ALA A 1 551 ? 26.397 -0.079 30.709 1.00 31.64 ? 567 ALA A CB 1 ATOM 4502 N N . LEU A 1 552 ? 27.780 -2.660 31.975 1.00 32.27 ? 568 LEU A N 1 ATOM 4503 C CA . LEU A 1 552 ? 28.123 -4.076 32.051 1.00 32.63 ? 568 LEU A CA 1 ATOM 4504 C C . LEU A 1 552 ? 27.685 -4.687 33.387 1.00 32.98 ? 568 LEU A C 1 ATOM 4505 O O . LEU A 1 552 ? 27.172 -5.806 33.418 1.00 32.88 ? 568 LEU A O 1 ATOM 4506 C CB . LEU A 1 552 ? 29.630 -4.285 31.830 1.00 32.45 ? 568 LEU A CB 1 ATOM 4507 C CG . LEU A 1 552 ? 30.231 -5.691 31.979 1.00 32.95 ? 568 LEU A CG 1 ATOM 4508 C CD1 . LEU A 1 552 ? 29.556 -6.744 31.094 1.00 32.01 ? 568 LEU A CD1 1 ATOM 4509 C CD2 . LEU A 1 552 ? 31.731 -5.652 31.716 1.00 33.33 ? 568 LEU A CD2 1 ATOM 4510 N N . GLU A 1 553 ? 27.887 -3.950 34.479 1.00 33.48 ? 569 GLU A N 1 ATOM 4511 C CA . GLU A 1 553 ? 27.493 -4.420 35.814 1.00 34.19 ? 569 GLU A CA 1 ATOM 4512 C C . GLU A 1 553 ? 25.986 -4.663 35.903 1.00 34.18 ? 569 GLU A C 1 ATOM 4513 O O . GLU A 1 553 ? 25.543 -5.652 36.483 1.00 34.22 ? 569 GLU A O 1 ATOM 4514 C CB . GLU A 1 553 ? 27.946 -3.440 36.900 1.00 34.43 ? 569 GLU A CB 1 ATOM 4515 C CG . GLU A 1 553 ? 27.802 -3.993 38.313 1.00 36.32 ? 569 GLU A CG 1 ATOM 4516 C CD . GLU A 1 553 ? 28.437 -3.115 39.380 1.00 38.35 ? 569 GLU A CD 1 ATOM 4517 O OE1 . GLU A 1 553 ? 28.599 -1.897 39.170 1.00 40.01 ? 569 GLU A OE1 1 ATOM 4518 O OE2 . GLU A 1 553 ? 28.772 -3.654 40.449 1.00 40.79 ? 569 GLU A OE2 1 ATOM 4519 N N . ALA A 1 554 ? 25.217 -3.761 35.300 1.00 34.59 ? 570 ALA A N 1 ATOM 4520 C CA . ALA A 1 554 ? 23.766 -3.886 35.210 1.00 35.04 ? 570 ALA A CA 1 ATOM 4521 C C . ALA A 1 554 ? 23.329 -5.144 34.461 1.00 35.23 ? 570 ALA A C 1 ATOM 4522 O O . ALA A 1 554 ? 22.245 -5.665 34.716 1.00 35.44 ? 570 ALA A O 1 ATOM 4523 C CB . ALA A 1 554 ? 23.165 -2.645 34.558 1.00 35.05 ? 570 ALA A CB 1 ATOM 4524 N N . PHE A 1 555 ? 24.173 -5.632 33.552 1.00 35.20 ? 571 PHE A N 1 ATOM 4525 C CA . PHE A 1 555 ? 23.854 -6.834 32.781 1.00 35.20 ? 571 PHE A CA 1 ATOM 4526 C C . PHE A 1 555 ? 24.163 -8.113 33.554 1.00 35.37 ? 571 PHE A C 1 ATOM 4527 O O . PHE A 1 555 ? 23.317 -9.004 33.627 1.00 35.70 ? 571 PHE A O 1 ATOM 4528 C CB . PHE A 1 555 ? 24.588 -6.838 31.432 1.00 35.02 ? 571 PHE A CB 1 ATOM 4529 C CG . PHE A 1 555 ? 24.146 -7.933 30.495 1.00 34.43 ? 571 PHE A CG 1 ATOM 4530 C CD1 . PHE A 1 555 ? 24.700 -9.208 30.576 1.00 35.34 ? 571 PHE A CD1 1 ATOM 4531 C CD2 . PHE A 1 555 ? 23.185 -7.685 29.520 1.00 34.77 ? 571 PHE A CD2 1 ATOM 4532 C CE1 . PHE A 1 555 ? 24.292 -10.228 29.702 1.00 35.40 ? 571 PHE A CE1 1 ATOM 4533 C CE2 . PHE A 1 555 ? 22.771 -8.691 28.642 1.00 34.70 ? 571 PHE A CE2 1 ATOM 4534 C CZ . PHE A 1 555 ? 23.324 -9.965 28.735 1.00 34.63 ? 571 PHE A CZ 1 ATOM 4535 N N . ASN A 1 556 ? 25.365 -8.203 34.125 1.00 35.37 ? 572 ASN A N 1 ATOM 4536 C CA . ASN A 1 556 ? 25.839 -9.456 34.714 1.00 35.65 ? 572 ASN A CA 1 ATOM 4537 C C . ASN A 1 556 ? 26.700 -9.323 35.973 1.00 35.90 ? 572 ASN A C 1 ATOM 4538 O O . ASN A 1 556 ? 27.335 -10.291 36.391 1.00 35.78 ? 572 ASN A O 1 ATOM 4539 C CB . ASN A 1 556 ? 26.583 -10.289 33.659 1.00 35.08 ? 572 ASN A CB 1 ATOM 4540 C CG . ASN A 1 556 ? 27.982 -9.753 33.342 1.00 35.44 ? 572 ASN A CG 1 ATOM 4541 O OD1 . ASN A 1 556 ? 28.378 -8.666 33.779 1.00 34.81 ? 572 ASN A OD1 1 ATOM 4542 N ND2 . ASN A 1 556 ? 28.737 -10.526 32.568 1.00 36.32 ? 572 ASN A ND2 1 ATOM 4543 N N . GLY A 1 557 ? 26.744 -8.123 36.549 1.00 36.64 ? 573 GLY A N 1 ATOM 4544 C CA . GLY A 1 557 ? 27.503 -7.881 37.786 1.00 36.81 ? 573 GLY A CA 1 ATOM 4545 C C . GLY A 1 557 ? 28.997 -7.648 37.617 1.00 37.11 ? 573 GLY A C 1 ATOM 4546 O O . GLY A 1 557 ? 29.693 -7.363 38.590 1.00 36.67 ? 573 GLY A O 1 ATOM 4547 N N . GLU A 1 558 ? 29.498 -7.761 36.388 1.00 37.34 ? 574 GLU A N 1 ATOM 4548 C CA . GLU A 1 558 ? 30.929 -7.561 36.129 1.00 37.69 ? 574 GLU A CA 1 ATOM 4549 C C . GLU A 1 558 ? 31.228 -6.124 35.716 1.00 37.19 ? 574 GLU A C 1 ATOM 4550 O O . GLU A 1 558 ? 30.339 -5.399 35.280 1.00 37.10 ? 574 GLU A O 1 ATOM 4551 C CB . GLU A 1 558 ? 31.435 -8.541 35.069 1.00 38.21 ? 574 GLU A CB 1 ATOM 4552 C CG . GLU A 1 558 ? 31.230 -10.004 35.448 1.00 40.37 ? 574 GLU A CG 1 ATOM 4553 C CD . GLU A 1 558 ? 31.948 -10.974 34.526 1.00 43.11 ? 574 GLU A CD 1 ATOM 4554 O OE1 . GLU A 1 558 ? 32.220 -10.630 33.351 1.00 43.14 ? 574 GLU A OE1 1 ATOM 4555 O OE2 . GLU A 1 558 ? 32.238 -12.097 34.988 1.00 45.62 ? 574 GLU A OE2 1 ATOM 4556 N N . ARG A 1 559 ? 32.486 -5.714 35.862 1.00 36.76 ? 575 ARG A N 1 ATOM 4557 C CA . ARG A 1 559 ? 32.888 -4.337 35.572 1.00 36.24 ? 575 ARG A CA 1 ATOM 4558 C C . ARG A 1 559 ? 34.087 -4.262 34.623 1.00 35.80 ? 575 ARG A C 1 ATOM 4559 O O . ARG A 1 559 ? 34.508 -3.173 34.229 1.00 35.61 ? 575 ARG A O 1 ATOM 4560 C CB . ARG A 1 559 ? 33.202 -3.592 36.877 1.00 36.36 ? 575 ARG A CB 1 ATOM 4561 C CG . ARG A 1 559 ? 31.981 -3.366 37.784 1.00 36.39 ? 575 ARG A CG 1 ATOM 4562 C CD . ARG A 1 559 ? 32.323 -2.506 39.002 1.00 36.27 ? 575 ARG A CD 1 ATOM 4563 N NE . ARG A 1 559 ? 32.872 -1.203 38.626 1.00 35.93 ? 575 ARG A NE 1 ATOM 4564 C CZ . ARG A 1 559 ? 32.144 -0.155 38.249 1.00 36.49 ? 575 ARG A CZ 1 ATOM 4565 N NH1 . ARG A 1 559 ? 30.820 -0.240 38.188 1.00 37.60 ? 575 ARG A NH1 1 ATOM 4566 N NH2 . ARG A 1 559 ? 32.743 0.981 37.924 1.00 36.52 ? 575 ARG A NH2 1 ATOM 4567 N N . ILE A 1 560 ? 34.627 -5.422 34.261 1.00 35.22 ? 576 ILE A N 1 ATOM 4568 C CA . ILE A 1 560 ? 35.874 -5.491 33.501 1.00 35.08 ? 576 ILE A CA 1 ATOM 4569 C C . ILE A 1 560 ? 35.667 -6.148 32.127 1.00 34.36 ? 576 ILE A C 1 ATOM 4570 O O . ILE A 1 560 ? 35.017 -7.180 32.017 1.00 33.87 ? 576 ILE A O 1 ATOM 4571 C CB . ILE A 1 560 ? 36.979 -6.233 34.313 1.00 35.28 ? 576 ILE A CB 1 ATOM 4572 C CG1 . ILE A 1 560 ? 37.264 -5.490 35.632 1.00 36.14 ? 576 ILE A CG1 1 ATOM 4573 C CG2 . ILE A 1 560 ? 38.275 -6.374 33.497 1.00 36.35 ? 576 ILE A CG2 1 ATOM 4574 C CD1 . ILE A 1 560 ? 37.933 -6.346 36.704 1.00 37.03 ? 576 ILE A CD1 1 ATOM 4575 N N . MET A 1 561 ? 36.209 -5.522 31.086 1.00 33.86 ? 577 MET A N 1 ATOM 4576 C CA . MET A 1 561 ? 36.270 -6.132 29.759 1.00 33.25 ? 577 MET A CA 1 ATOM 4577 C C . MET A 1 561 ? 37.291 -7.270 29.800 1.00 33.03 ? 577 MET A C 1 ATOM 4578 O O . MET A 1 561 ? 38.454 -7.054 30.148 1.00 33.17 ? 577 MET A O 1 ATOM 4579 C CB . MET A 1 561 ? 36.656 -5.078 28.717 1.00 32.99 ? 577 MET A CB 1 ATOM 4580 C CG . MET A 1 561 ? 36.867 -5.614 27.300 1.00 32.48 ? 577 MET A CG 1 ATOM 4581 S SD . MET A 1 561 ? 37.156 -4.258 26.145 1.00 32.63 ? 577 MET A SD 1 ATOM 4582 C CE . MET A 1 561 ? 38.792 -3.709 26.648 1.00 32.55 ? 577 MET A CE 1 ATOM 4583 N N . SER A 1 562 ? 36.850 -8.476 29.448 1.00 32.95 ? 578 SER A N 1 ATOM 4584 C CA . SER A 1 562 ? 37.662 -9.679 29.603 1.00 32.85 ? 578 SER A CA 1 ATOM 4585 C C . SER A 1 562 ? 37.563 -10.638 28.419 1.00 32.75 ? 578 SER A C 1 ATOM 4586 O O . SER A 1 562 ? 36.474 -10.898 27.903 1.00 32.79 ? 578 SER A O 1 ATOM 4587 C CB . SER A 1 562 ? 37.253 -10.413 30.889 1.00 33.02 ? 578 SER A CB 1 ATOM 4588 O OG . SER A 1 562 ? 37.985 -11.615 31.056 1.00 33.40 ? 578 SER A OG 1 ATOM 4589 N N . GLY A 1 563 ? 38.706 -11.187 28.019 1.00 32.71 ? 579 GLY A N 1 ATOM 4590 C CA . GLY A 1 563 ? 38.756 -12.221 26.976 1.00 32.56 ? 579 GLY A CA 1 ATOM 4591 C C . GLY A 1 563 ? 38.469 -13.631 27.490 1.00 32.73 ? 579 GLY A C 1 ATOM 4592 O O . GLY A 1 563 ? 38.510 -14.594 26.727 1.00 32.00 ? 579 GLY A O 1 ATOM 4593 N N . LYS A 1 564 ? 38.168 -13.753 28.784 1.00 32.81 ? 580 LYS A N 1 ATOM 4594 C CA . LYS A 1 564 ? 37.861 -15.058 29.390 1.00 33.34 ? 580 LYS A CA 1 ATOM 4595 C C . LYS A 1 564 ? 36.711 -15.782 28.686 1.00 32.82 ? 580 LYS A C 1 ATOM 4596 O O . LYS A 1 564 ? 36.826 -16.966 28.366 1.00 32.89 ? 580 LYS A O 1 ATOM 4597 C CB . LYS A 1 564 ? 37.546 -14.905 30.890 1.00 33.79 ? 580 LYS A CB 1 ATOM 4598 C CG . LYS A 1 564 ? 37.181 -16.208 31.588 1.00 36.48 ? 580 LYS A CG 1 ATOM 4599 C CD . LYS A 1 564 ? 36.864 -15.983 33.070 1.00 40.52 ? 580 LYS A CD 1 ATOM 4600 C CE . LYS A 1 564 ? 36.395 -17.276 33.735 1.00 42.26 ? 580 LYS A CE 1 ATOM 4601 N NZ . LYS A 1 564 ? 36.184 -17.072 35.195 1.00 44.79 ? 580 LYS A NZ 1 ATOM 4602 N N . ALA A 1 565 ? 35.611 -15.071 28.442 1.00 32.42 ? 581 ALA A N 1 ATOM 4603 C CA . ALA A 1 565 ? 34.413 -15.689 27.870 1.00 32.53 ? 581 ALA A CA 1 ATOM 4604 C C . ALA A 1 565 ? 34.603 -16.186 26.427 1.00 32.29 ? 581 ALA A C 1 ATOM 4605 O O . ALA A 1 565 ? 34.120 -17.262 26.072 1.00 32.73 ? 581 ALA A O 1 ATOM 4606 C CB . ALA A 1 565 ? 33.217 -14.746 27.968 1.00 32.28 ? 581 ALA A CB 1 ATOM 4607 N N . ILE A 1 566 ? 35.303 -15.414 25.602 1.00 32.09 ? 582 ILE A N 1 ATOM 4608 C CA . ILE A 1 566 ? 35.568 -15.846 24.227 1.00 31.84 ? 582 ILE A CA 1 ATOM 4609 C C . ILE A 1 566 ? 36.495 -17.073 24.200 1.00 32.00 ? 582 ILE A C 1 ATOM 4610 O O . ILE A 1 566 ? 36.283 -18.003 23.418 1.00 31.93 ? 582 ILE A O 1 ATOM 4611 C CB . ILE A 1 566 ? 36.078 -14.677 23.320 1.00 31.72 ? 582 ILE A CB 1 ATOM 4612 C CG1 . ILE A 1 566 ? 36.116 -15.111 21.846 1.00 31.39 ? 582 ILE A CG1 1 ATOM 4613 C CG2 . ILE A 1 566 ? 37.440 -14.129 23.811 1.00 31.74 ? 582 ILE A CG2 1 ATOM 4614 C CD1 . ILE A 1 566 ? 36.315 -13.967 20.866 1.00 30.84 ? 582 ILE A CD1 1 ATOM 4615 N N . ALA A 1 567 ? 37.493 -17.088 25.080 1.00 32.42 ? 583 ALA A N 1 ATOM 4616 C CA . ALA A 1 567 ? 38.402 -18.234 25.191 1.00 32.91 ? 583 ALA A CA 1 ATOM 4617 C C . ALA A 1 567 ? 37.657 -19.486 25.665 1.00 33.30 ? 583 ALA A C 1 ATOM 4618 O O . ALA A 1 567 ? 37.922 -20.599 25.198 1.00 33.32 ? 583 ALA A O 1 ATOM 4619 C CB . ALA A 1 567 ? 39.567 -17.912 26.125 1.00 33.04 ? 583 ALA A CB 1 ATOM 4620 N N . GLU A 1 568 ? 36.711 -19.282 26.579 1.00 33.63 ? 584 GLU A N 1 ATOM 4621 C CA . GLU A 1 568 ? 35.894 -20.362 27.136 1.00 33.87 ? 584 GLU A CA 1 ATOM 4622 C C . GLU A 1 568 ? 35.037 -20.998 26.043 1.00 33.54 ? 584 GLU A C 1 ATOM 4623 O O . GLU A 1 568 ? 34.963 -22.221 25.928 1.00 33.63 ? 584 GLU A O 1 ATOM 4624 C CB . GLU A 1 568 ? 35.023 -19.807 28.270 1.00 33.98 ? 584 GLU A CB 1 ATOM 4625 C CG . GLU A 1 568 ? 34.202 -20.830 29.024 1.00 35.00 ? 584 GLU A CG 1 ATOM 4626 C CD . GLU A 1 568 ? 33.584 -20.255 30.299 1.00 36.84 ? 584 GLU A CD 1 ATOM 4627 O OE1 . GLU A 1 568 ? 34.106 -19.250 30.839 1.00 36.76 ? 584 GLU A OE1 1 ATOM 4628 O OE2 . GLU A 1 568 ? 32.572 -20.812 30.760 1.00 37.00 ? 584 GLU A OE2 1 ATOM 4629 N N . TYR A 1 569 ? 34.407 -20.153 25.235 1.00 33.13 ? 585 TYR A N 1 ATOM 4630 C CA . TYR A 1 569 ? 33.598 -20.599 24.105 1.00 33.01 ? 585 TYR A CA 1 ATOM 4631 C C . TYR A 1 569 ? 34.389 -21.501 23.147 1.00 33.00 ? 585 TYR A C 1 ATOM 4632 O O . TYR A 1 569 ? 33.898 -22.544 22.716 1.00 33.10 ? 585 TYR A O 1 ATOM 4633 C CB . TYR A 1 569 ? 33.057 -19.376 23.357 1.00 32.50 ? 585 TYR A CB 1 ATOM 4634 C CG . TYR A 1 569 ? 32.058 -19.682 22.264 1.00 32.35 ? 585 TYR A CG 1 ATOM 4635 C CD1 . TYR A 1 569 ? 32.475 -20.146 21.009 1.00 31.50 ? 585 TYR A CD1 1 ATOM 4636 C CD2 . TYR A 1 569 ? 30.693 -19.481 22.470 1.00 31.21 ? 585 TYR A CD2 1 ATOM 4637 C CE1 . TYR A 1 569 ? 31.553 -20.421 20.002 1.00 30.92 ? 585 TYR A CE1 1 ATOM 4638 C CE2 . TYR A 1 569 ? 29.766 -19.742 21.462 1.00 30.80 ? 585 TYR A CE2 1 ATOM 4639 C CZ . TYR A 1 569 ? 30.206 -20.213 20.234 1.00 30.33 ? 585 TYR A CZ 1 ATOM 4640 O OH . TYR A 1 569 ? 29.298 -20.476 19.240 1.00 30.97 ? 585 TYR A OH 1 ATOM 4641 N N . PHE A 1 570 ? 35.615 -21.099 22.829 1.00 33.28 ? 586 PHE A N 1 ATOM 4642 C CA . PHE A 1 570 ? 36.404 -21.784 21.805 1.00 33.54 ? 586 PHE A CA 1 ATOM 4643 C C . PHE A 1 570 ? 37.377 -22.837 22.332 1.00 33.87 ? 586 PHE A C 1 ATOM 4644 O O . PHE A 1 570 ? 38.039 -23.507 21.543 1.00 33.94 ? 586 PHE A O 1 ATOM 4645 C CB . PHE A 1 570 ? 37.136 -20.763 20.944 1.00 33.04 ? 586 PHE A CB 1 ATOM 4646 C CG . PHE A 1 570 ? 36.232 -20.008 20.035 1.00 33.02 ? 586 PHE A CG 1 ATOM 4647 C CD1 . PHE A 1 570 ? 35.723 -20.615 18.886 1.00 32.64 ? 586 PHE A CD1 1 ATOM 4648 C CD2 . PHE A 1 570 ? 35.868 -18.697 20.326 1.00 32.15 ? 586 PHE A CD2 1 ATOM 4649 C CE1 . PHE A 1 570 ? 34.865 -19.925 18.036 1.00 32.19 ? 586 PHE A CE1 1 ATOM 4650 C CE2 . PHE A 1 570 ? 35.015 -17.993 19.475 1.00 32.75 ? 586 PHE A CE2 1 ATOM 4651 C CZ . PHE A 1 570 ? 34.515 -18.610 18.326 1.00 32.48 ? 586 PHE A CZ 1 ATOM 4652 N N . GLU A 1 571 ? 37.447 -22.986 23.655 1.00 34.19 ? 587 GLU A N 1 ATOM 4653 C CA . GLU A 1 571 ? 38.367 -23.937 24.290 1.00 34.80 ? 587 GLU A CA 1 ATOM 4654 C C . GLU A 1 571 ? 38.335 -25.361 23.699 1.00 34.50 ? 587 GLU A C 1 ATOM 4655 O O . GLU A 1 571 ? 39.395 -25.929 23.451 1.00 34.72 ? 587 GLU A O 1 ATOM 4656 C CB . GLU A 1 571 ? 38.196 -23.938 25.824 1.00 35.13 ? 587 GLU A CB 1 ATOM 4657 C CG . GLU A 1 571 ? 39.036 -24.976 26.575 1.00 36.93 ? 587 GLU A CG 1 ATOM 4658 C CD . GLU A 1 571 ? 40.534 -24.666 26.626 1.00 40.00 ? 587 GLU A CD 1 ATOM 4659 O OE1 . GLU A 1 571 ? 40.968 -23.572 26.194 1.00 40.79 ? 587 GLU A OE1 1 ATOM 4660 O OE2 . GLU A 1 571 ? 41.288 -25.537 27.117 1.00 42.32 ? 587 GLU A OE2 1 ATOM 4661 N N . PRO A 1 572 ? 37.136 -25.932 23.442 1.00 34.46 ? 588 PRO A N 1 ATOM 4662 C CA . PRO A 1 572 ? 37.145 -27.264 22.821 1.00 34.19 ? 588 PRO A CA 1 ATOM 4663 C C . PRO A 1 572 ? 37.772 -27.264 21.423 1.00 34.15 ? 588 PRO A C 1 ATOM 4664 O O . PRO A 1 572 ? 38.388 -28.258 21.026 1.00 34.10 ? 588 PRO A O 1 ATOM 4665 C CB . PRO A 1 572 ? 35.658 -27.633 22.736 1.00 34.29 ? 588 PRO A CB 1 ATOM 4666 C CG . PRO A 1 572 ? 34.981 -26.747 23.723 1.00 34.71 ? 588 PRO A CG 1 ATOM 4667 C CD . PRO A 1 572 ? 35.762 -25.478 23.731 1.00 34.38 ? 588 PRO A CD 1 ATOM 4668 N N . LEU A 1 573 ? 37.621 -26.163 20.689 1.00 34.06 ? 589 LEU A N 1 ATOM 4669 C CA . LEU A 1 573 ? 38.270 -26.028 19.381 1.00 33.94 ? 589 LEU A CA 1 ATOM 4670 C C . LEU A 1 573 ? 39.785 -25.909 19.542 1.00 34.11 ? 589 LEU A C 1 ATOM 4671 O O . LEU A 1 573 ? 40.534 -26.567 18.826 1.00 33.91 ? 589 LEU A O 1 ATOM 4672 C CB . LEU A 1 573 ? 37.714 -24.833 18.596 1.00 33.67 ? 589 LEU A CB 1 ATOM 4673 C CG . LEU A 1 573 ? 38.374 -24.558 17.236 1.00 33.42 ? 589 LEU A CG 1 ATOM 4674 C CD1 . LEU A 1 573 ? 38.133 -25.700 16.248 1.00 32.43 ? 589 LEU A CD1 1 ATOM 4675 C CD2 . LEU A 1 573 ? 37.887 -23.241 16.661 1.00 33.05 ? 589 LEU A CD2 1 ATOM 4676 N N . ARG A 1 574 ? 40.229 -25.086 20.493 1.00 34.72 ? 590 ARG A N 1 ATOM 4677 C CA . ARG A 1 574 ? 41.664 -24.899 20.739 1.00 35.38 ? 590 ARG A CA 1 ATOM 4678 C C . ARG A 1 574 ? 42.360 -26.237 20.983 1.00 35.86 ? 590 ARG A C 1 ATOM 4679 O O . ARG A 1 574 ? 43.384 -26.528 20.361 1.00 36.04 ? 590 ARG A O 1 ATOM 4680 C CB . ARG A 1 574 ? 41.921 -23.947 21.914 1.00 35.35 ? 590 ARG A CB 1 ATOM 4681 C CG . ARG A 1 574 ? 43.406 -23.666 22.162 1.00 35.89 ? 590 ARG A CG 1 ATOM 4682 C CD . ARG A 1 574 ? 43.664 -22.985 23.510 1.00 37.96 ? 590 ARG A CD 1 ATOM 4683 N NE . ARG A 1 574 ? 43.410 -23.866 24.652 1.00 39.44 ? 590 ARG A NE 1 ATOM 4684 C CZ . ARG A 1 574 ? 44.257 -24.785 25.116 1.00 40.83 ? 590 ARG A CZ 1 ATOM 4685 N NH1 . ARG A 1 574 ? 45.437 -24.981 24.540 1.00 41.03 ? 590 ARG A NH1 1 ATOM 4686 N NH2 . ARG A 1 574 ? 43.916 -25.521 26.167 1.00 41.83 ? 590 ARG A NH2 1 ATOM 4687 N N . VAL A 1 575 ? 41.787 -27.041 21.878 1.00 36.20 ? 591 VAL A N 1 ATOM 4688 C CA . VAL A 1 575 ? 42.323 -28.361 22.206 1.00 36.67 ? 591 VAL A CA 1 ATOM 4689 C C . VAL A 1 575 ? 42.394 -29.257 20.965 1.00 36.58 ? 591 VAL A C 1 ATOM 4690 O O . VAL A 1 575 ? 43.447 -29.824 20.672 1.00 37.03 ? 591 VAL A O 1 ATOM 4691 C CB . VAL A 1 575 ? 41.521 -29.048 23.357 1.00 36.74 ? 591 VAL A CB 1 ATOM 4692 C CG1 . VAL A 1 575 ? 42.022 -30.476 23.608 1.00 37.09 ? 591 VAL A CG1 1 ATOM 4693 C CG2 . VAL A 1 575 ? 41.618 -28.224 24.637 1.00 37.18 ? 591 VAL A CG2 1 ATOM 4694 N N . TRP A 1 576 ? 41.290 -29.369 20.232 1.00 36.46 ? 592 TRP A N 1 ATOM 4695 C CA . TRP A 1 576 ? 41.266 -30.187 19.015 1.00 36.41 ? 592 TRP A CA 1 ATOM 4696 C C . TRP A 1 576 ? 42.245 -29.686 17.952 1.00 36.29 ? 592 TRP A C 1 ATOM 4697 O O . TRP A 1 576 ? 42.968 -30.483 17.339 1.00 36.39 ? 592 TRP A O 1 ATOM 4698 C CB . TRP A 1 576 ? 39.854 -30.274 18.416 1.00 36.28 ? 592 TRP A CB 1 ATOM 4699 C CG . TRP A 1 576 ? 39.820 -31.107 17.163 1.00 36.28 ? 592 TRP A CG 1 ATOM 4700 C CD1 . TRP A 1 576 ? 39.638 -32.461 17.084 1.00 36.02 ? 592 TRP A CD1 1 ATOM 4701 C CD2 . TRP A 1 576 ? 40.001 -30.646 15.812 1.00 36.12 ? 592 TRP A CD2 1 ATOM 4702 N NE1 . TRP A 1 576 ? 39.683 -32.867 15.768 1.00 37.05 ? 592 TRP A NE1 1 ATOM 4703 C CE2 . TRP A 1 576 ? 39.910 -31.777 14.968 1.00 36.18 ? 592 TRP A CE2 1 ATOM 4704 C CE3 . TRP A 1 576 ? 40.230 -29.387 15.235 1.00 36.07 ? 592 TRP A CE3 1 ATOM 4705 C CZ2 . TRP A 1 576 ? 40.034 -31.688 13.572 1.00 36.68 ? 592 TRP A CZ2 1 ATOM 4706 C CZ3 . TRP A 1 576 ? 40.360 -29.299 13.842 1.00 36.92 ? 592 TRP A CZ3 1 ATOM 4707 C CH2 . TRP A 1 576 ? 40.261 -30.444 13.032 1.00 36.45 ? 592 TRP A CH2 1 ATOM 4708 N N . LEU A 1 577 ? 42.255 -28.372 17.735 1.00 36.06 ? 593 LEU A N 1 ATOM 4709 C CA . LEU A 1 577 ? 43.039 -27.764 16.654 1.00 35.76 ? 593 LEU A CA 1 ATOM 4710 C C . LEU A 1 577 ? 44.544 -27.828 16.901 1.00 35.74 ? 593 LEU A C 1 ATOM 4711 O O . LEU A 1 577 ? 45.309 -28.101 15.974 1.00 35.14 ? 593 LEU A O 1 ATOM 4712 C CB . LEU A 1 577 ? 42.584 -26.322 16.383 1.00 35.56 ? 593 LEU A CB 1 ATOM 4713 C CG . LEU A 1 577 ? 43.195 -25.567 15.195 1.00 35.36 ? 593 LEU A CG 1 ATOM 4714 C CD1 . LEU A 1 577 ? 42.922 -26.253 13.854 1.00 34.96 ? 593 LEU A CD1 1 ATOM 4715 C CD2 . LEU A 1 577 ? 42.679 -24.138 15.182 1.00 34.82 ? 593 LEU A CD2 1 ATOM 4716 N N . GLU A 1 578 ? 44.964 -27.571 18.141 1.00 35.85 ? 594 GLU A N 1 ATOM 4717 C CA . GLU A 1 578 ? 46.369 -27.724 18.501 1.00 36.31 ? 594 GLU A CA 1 ATOM 4718 C C . GLU A 1 578 ? 46.841 -29.137 18.162 1.00 36.47 ? 594 GLU A C 1 ATOM 4719 O O . GLU A 1 578 ? 47.873 -29.308 17.509 1.00 36.61 ? 594 GLU A O 1 ATOM 4720 C CB . GLU A 1 578 ? 46.615 -27.393 19.979 1.00 36.49 ? 594 GLU A CB 1 ATOM 4721 C CG . GLU A 1 578 ? 46.673 -25.897 20.259 1.00 37.44 ? 594 GLU A CG 1 ATOM 4722 C CD . GLU A 1 578 ? 46.982 -25.560 21.711 1.00 39.35 ? 594 GLU A CD 1 ATOM 4723 O OE1 . GLU A 1 578 ? 47.482 -26.436 22.450 1.00 40.76 ? 594 GLU A OE1 1 ATOM 4724 O OE2 . GLU A 1 578 ? 46.724 -24.408 22.117 1.00 39.41 ? 594 GLU A OE2 1 ATOM 4725 N N . ALA A 1 579 ? 46.058 -30.135 18.573 1.00 36.56 ? 595 ALA A N 1 ATOM 4726 C CA . ALA A 1 579 ? 46.370 -31.539 18.315 1.00 36.58 ? 595 ALA A CA 1 ATOM 4727 C C . ALA A 1 579 ? 46.365 -31.881 16.824 1.00 36.63 ? 595 ALA A C 1 ATOM 4728 O O . ALA A 1 579 ? 47.230 -32.625 16.352 1.00 36.52 ? 595 ALA A O 1 ATOM 4729 C CB . ALA A 1 579 ? 45.411 -32.447 19.070 1.00 36.60 ? 595 ALA A CB 1 ATOM 4730 N N . GLU A 1 580 ? 45.399 -31.337 16.088 1.00 36.68 ? 596 GLU A N 1 ATOM 4731 C CA . GLU A 1 580 ? 45.275 -31.622 14.659 1.00 37.05 ? 596 GLU A CA 1 ATOM 4732 C C . GLU A 1 580 ? 46.421 -31.037 13.835 1.00 37.04 ? 596 GLU A C 1 ATOM 4733 O O . GLU A 1 580 ? 46.851 -31.636 12.842 1.00 37.62 ? 596 GLU A O 1 ATOM 4734 C CB . GLU A 1 580 ? 43.932 -31.129 14.121 1.00 37.22 ? 596 GLU A CB 1 ATOM 4735 C CG . GLU A 1 580 ? 43.626 -31.577 12.691 1.00 37.95 ? 596 GLU A CG 1 ATOM 4736 C CD . GLU A 1 580 ? 43.268 -33.053 12.588 1.00 40.09 ? 596 GLU A CD 1 ATOM 4737 O OE1 . GLU A 1 580 ? 43.154 -33.734 13.634 1.00 41.23 ? 596 GLU A OE1 1 ATOM 4738 O OE2 . GLU A 1 580 ? 43.093 -33.533 11.453 1.00 40.85 ? 596 GLU A OE2 1 ATOM 4739 N N . ASN A 1 581 ? 46.895 -29.861 14.236 1.00 36.88 ? 597 ASN A N 1 ATOM 4740 C CA . ASN A 1 581 ? 48.040 -29.229 13.588 1.00 36.86 ? 597 ASN A CA 1 ATOM 4741 C C . ASN A 1 581 ? 49.341 -30.003 13.821 1.00 37.06 ? 597 ASN A C 1 ATOM 4742 O O . ASN A 1 581 ? 50.154 -30.146 12.906 1.00 36.97 ? 597 ASN A O 1 ATOM 4743 C CB . ASN A 1 581 ? 48.182 -27.771 14.033 1.00 36.55 ? 597 ASN A CB 1 ATOM 4744 C CG . ASN A 1 581 ? 47.237 -26.834 13.285 1.00 36.35 ? 597 ASN A CG 1 ATOM 4745 O OD1 . ASN A 1 581 ? 46.740 -27.153 12.198 1.00 35.37 ? 597 ASN A OD1 1 ATOM 4746 N ND2 . ASN A 1 581 ? 47.001 -25.660 13.860 1.00 35.16 ? 597 ASN A ND2 1 ATOM 4747 N N . ILE A 1 582 ? 49.525 -30.501 15.044 1.00 37.10 ? 598 ILE A N 1 ATOM 4748 C CA . ILE A 1 582 ? 50.668 -31.356 15.365 1.00 37.30 ? 598 ILE A CA 1 ATOM 4749 C C . ILE A 1 582 ? 50.578 -32.656 14.560 1.00 37.39 ? 598 ILE A C 1 ATOM 4750 O O . ILE A 1 582 ? 51.552 -33.070 13.933 1.00 37.56 ? 598 ILE A O 1 ATOM 4751 C CB . ILE A 1 582 ? 50.778 -31.631 16.896 1.00 37.38 ? 598 ILE A CB 1 ATOM 4752 C CG1 . ILE A 1 582 ? 51.219 -30.359 17.637 1.00 37.15 ? 598 ILE A CG1 1 ATOM 4753 C CG2 . ILE A 1 582 ? 51.742 -32.800 17.181 1.00 37.47 ? 598 ILE A CG2 1 ATOM 4754 C CD1 . ILE A 1 582 ? 51.043 -30.419 19.166 1.00 37.96 ? 598 ILE A CD1 1 ATOM 4755 N N . LYS A 1 583 ? 49.394 -33.263 14.547 1.00 37.48 ? 599 LYS A N 1 ATOM 4756 C CA . LYS A 1 583 ? 49.149 -34.503 13.815 1.00 37.87 ? 599 LYS A CA 1 ATOM 4757 C C . LYS A 1 583 ? 49.536 -34.383 12.336 1.00 37.59 ? 599 LYS A C 1 ATOM 4758 O O . LYS A 1 583 ? 50.113 -35.305 11.764 1.00 37.58 ? 599 LYS A O 1 ATOM 4759 C CB . LYS A 1 583 ? 47.680 -34.915 13.952 1.00 38.11 ? 599 LYS A CB 1 ATOM 4760 C CG . LYS A 1 583 ? 47.345 -36.277 13.368 1.00 40.23 ? 599 LYS A CG 1 ATOM 4761 C CD . LYS A 1 583 ? 45.840 -36.539 13.355 1.00 43.02 ? 599 LYS A CD 1 ATOM 4762 C CE . LYS A 1 583 ? 45.485 -37.613 12.314 1.00 44.86 ? 599 LYS A CE 1 ATOM 4763 N NZ . LYS A 1 583 ? 44.048 -38.035 12.358 1.00 45.23 ? 599 LYS A NZ 1 ATOM 4764 N N . ASN A 1 584 ? 49.227 -33.235 11.739 1.00 37.10 ? 600 ASN A N 1 ATOM 4765 C CA . ASN A 1 584 ? 49.478 -32.988 10.324 1.00 36.77 ? 600 ASN A CA 1 ATOM 4766 C C . ASN A 1 584 ? 50.758 -32.193 10.058 1.00 36.41 ? 600 ASN A C 1 ATOM 4767 O O . ASN A 1 584 ? 50.977 -31.726 8.935 1.00 36.21 ? 600 ASN A O 1 ATOM 4768 C CB . ASN A 1 584 ? 48.268 -32.284 9.699 1.00 36.69 ? 600 ASN A CB 1 ATOM 4769 C CG . ASN A 1 584 ? 47.113 -33.228 9.452 1.00 37.49 ? 600 ASN A CG 1 ATOM 4770 O OD1 . ASN A 1 584 ? 47.031 -33.862 8.400 1.00 38.45 ? 600 ASN A OD1 1 ATOM 4771 N ND2 . ASN A 1 584 ? 46.207 -33.325 10.419 1.00 38.08 ? 600 ASN A ND2 1 ATOM 4772 N N . ASN A 1 585 ? 51.596 -32.040 11.088 1.00 35.93 ? 601 ASN A N 1 ATOM 4773 C CA . ASN A 1 585 ? 52.866 -31.310 10.970 1.00 35.75 ? 601 ASN A CA 1 ATOM 4774 C C . ASN A 1 585 ? 52.681 -29.952 10.282 1.00 35.19 ? 601 ASN A C 1 ATOM 4775 O O . ASN A 1 585 ? 53.454 -29.568 9.399 1.00 34.69 ? 601 ASN A O 1 ATOM 4776 C CB . ASN A 1 585 ? 53.917 -32.163 10.230 1.00 35.89 ? 601 ASN A CB 1 ATOM 4777 C CG . ASN A 1 585 ? 55.345 -31.694 10.480 1.00 36.93 ? 601 ASN A CG 1 ATOM 4778 O OD1 . ASN A 1 585 ? 55.637 -31.062 11.495 1.00 37.43 ? 601 ASN A OD1 1 ATOM 4779 N ND2 . ASN A 1 585 ? 56.243 -32.013 9.553 1.00 36.87 ? 601 ASN A ND2 1 ATOM 4780 N N . VAL A 1 586 ? 51.640 -29.234 10.703 1.00 34.65 ? 602 VAL A N 1 ATOM 4781 C CA . VAL A 1 586 ? 51.248 -27.973 10.079 1.00 33.86 ? 602 VAL A CA 1 ATOM 4782 C C . VAL A 1 586 ? 52.186 -26.840 10.484 1.00 33.68 ? 602 VAL A C 1 ATOM 4783 O O . VAL A 1 586 ? 52.413 -26.601 11.680 1.00 33.29 ? 602 VAL A O 1 ATOM 4784 C CB . VAL A 1 586 ? 49.783 -27.606 10.432 1.00 34.02 ? 602 VAL A CB 1 ATOM 4785 C CG1 . VAL A 1 586 ? 49.422 -26.220 9.903 1.00 33.01 ? 602 VAL A CG1 1 ATOM 4786 C CG2 . VAL A 1 586 ? 48.821 -28.657 9.884 1.00 33.67 ? 602 VAL A CG2 1 ATOM 4787 N N . HIS A 1 587 ? 52.731 -26.152 9.481 1.00 32.91 ? 603 HIS A N 1 ATOM 4788 C CA . HIS A 1 587 ? 53.572 -24.987 9.717 1.00 32.74 ? 603 HIS A CA 1 ATOM 4789 C C . HIS A 1 587 ? 52.742 -23.814 10.242 1.00 32.65 ? 603 HIS A C 1 ATOM 4790 O O . HIS A 1 587 ? 51.676 -23.494 9.704 1.00 32.69 ? 603 HIS A O 1 ATOM 4791 C CB . HIS A 1 587 ? 54.337 -24.588 8.451 1.00 32.91 ? 603 HIS A CB 1 ATOM 4792 C CG . HIS A 1 587 ? 55.257 -23.424 8.650 1.00 33.42 ? 603 HIS A CG 1 ATOM 4793 N ND1 . HIS A 1 587 ? 56.497 -23.547 9.239 1.00 33.53 ? 603 HIS A ND1 1 ATOM 4794 C CD2 . HIS A 1 587 ? 55.101 -22.108 8.373 1.00 33.50 ? 603 HIS A CD2 1 ATOM 4795 C CE1 . HIS A 1 587 ? 57.073 -22.359 9.297 1.00 34.15 ? 603 HIS A CE1 1 ATOM 4796 N NE2 . HIS A 1 587 ? 56.245 -21.468 8.782 1.00 33.76 ? 603 HIS A NE2 1 ATOM 4797 N N . ILE A 1 588 ? 53.244 -23.191 11.305 1.00 32.55 ? 604 ILE A N 1 ATOM 4798 C CA . ILE A 1 588 ? 52.584 -22.069 11.972 1.00 32.37 ? 604 ILE A CA 1 ATOM 4799 C C . ILE A 1 588 ? 53.468 -20.834 11.834 1.00 32.06 ? 604 ILE A C 1 ATOM 4800 O O . ILE A 1 588 ? 54.685 -20.922 11.969 1.00 32.47 ? 604 ILE A O 1 ATOM 4801 C CB . ILE A 1 588 ? 52.329 -22.384 13.483 1.00 32.34 ? 604 ILE A CB 1 ATOM 4802 C CG1 . ILE A 1 588 ? 51.535 -23.694 13.655 1.00 32.40 ? 604 ILE A CG1 1 ATOM 4803 C CG2 . ILE A 1 588 ? 51.649 -21.197 14.204 1.00 32.98 ? 604 ILE A CG2 1 ATOM 4804 C CD1 . ILE A 1 588 ? 50.116 -23.693 13.033 1.00 33.02 ? 604 ILE A CD1 1 ATOM 4805 N N . GLY A 1 589 ? 52.855 -19.686 11.565 1.00 31.91 ? 605 GLY A N 1 ATOM 4806 C CA . GLY A 1 589 ? 53.595 -18.436 11.398 1.00 31.57 ? 605 GLY A CA 1 ATOM 4807 C C . GLY A 1 589 ? 53.867 -18.176 9.924 1.00 31.72 ? 605 GLY A C 1 ATOM 4808 O O . GLY A 1 589 ? 53.583 -19.022 9.074 1.00 31.55 ? 605 GLY A O 1 ATOM 4809 N N . TRP A 1 590 ? 54.417 -17.006 9.621 1.00 31.60 ? 606 TRP A N 1 ATOM 4810 C CA . TRP A 1 590 ? 54.641 -16.612 8.232 1.00 31.79 ? 606 TRP A CA 1 ATOM 4811 C C . TRP A 1 590 ? 55.836 -15.689 8.086 1.00 31.90 ? 606 TRP A C 1 ATOM 4812 O O . TRP A 1 590 ? 56.177 -14.940 8.998 1.00 31.70 ? 606 TRP A O 1 ATOM 4813 C CB . TRP A 1 590 ? 53.388 -15.954 7.639 1.00 31.37 ? 606 TRP A CB 1 ATOM 4814 C CG . TRP A 1 590 ? 52.855 -14.820 8.462 1.00 31.18 ? 606 TRP A CG 1 ATOM 4815 C CD1 . TRP A 1 590 ? 53.212 -13.508 8.374 1.00 30.44 ? 606 TRP A CD1 1 ATOM 4816 C CD2 . TRP A 1 590 ? 51.872 -14.900 9.504 1.00 30.27 ? 606 TRP A CD2 1 ATOM 4817 N NE1 . TRP A 1 590 ? 52.513 -12.763 9.291 1.00 29.85 ? 606 TRP A NE1 1 ATOM 4818 C CE2 . TRP A 1 590 ? 51.686 -13.594 10.002 1.00 30.47 ? 606 TRP A CE2 1 ATOM 4819 C CE3 . TRP A 1 590 ? 51.134 -15.952 10.070 1.00 30.09 ? 606 TRP A CE3 1 ATOM 4820 C CZ2 . TRP A 1 590 ? 50.782 -13.304 11.035 1.00 29.26 ? 606 TRP A CZ2 1 ATOM 4821 C CZ3 . TRP A 1 590 ? 50.233 -15.664 11.089 1.00 28.57 ? 606 TRP A CZ3 1 ATOM 4822 C CH2 . TRP A 1 590 ? 50.065 -14.349 11.557 1.00 29.37 ? 606 TRP A CH2 1 ATOM 4823 N N . THR A 1 591 ? 56.468 -15.754 6.922 1.00 32.27 ? 607 THR A N 1 ATOM 4824 C CA . THR A 1 591 ? 57.550 -14.849 6.576 1.00 32.48 ? 607 THR A CA 1 ATOM 4825 C C . THR A 1 591 ? 56.962 -13.488 6.190 1.00 32.79 ? 607 THR A C 1 ATOM 4826 O O . THR A 1 591 ? 55.769 -13.381 5.899 1.00 32.53 ? 607 THR A O 1 ATOM 4827 C CB . THR A 1 591 ? 58.380 -15.405 5.396 1.00 32.63 ? 607 THR A CB 1 ATOM 4828 O OG1 . THR A 1 591 ? 57.504 -15.718 4.309 1.00 32.09 ? 607 THR A OG1 1 ATOM 4829 C CG2 . THR A 1 591 ? 59.128 -16.667 5.802 1.00 32.95 ? 607 THR A CG2 1 ATOM 4830 N N . THR A 1 592 ? 57.801 -12.455 6.192 1.00 33.22 ? 608 THR A N 1 ATOM 4831 C CA . THR A 1 592 ? 57.382 -11.107 5.798 1.00 33.97 ? 608 THR A CA 1 ATOM 4832 C C . THR A 1 592 ? 57.001 -11.060 4.311 1.00 34.06 ? 608 THR A C 1 ATOM 4833 O O . THR A 1 592 ? 57.724 -11.586 3.457 1.00 33.80 ? 608 THR A O 1 ATOM 4834 C CB . THR A 1 592 ? 58.467 -10.067 6.156 1.00 34.06 ? 608 THR A CB 1 ATOM 4835 O OG1 . THR A 1 592 ? 58.651 -10.074 7.578 1.00 34.91 ? 608 THR A OG1 1 ATOM 4836 C CG2 . THR A 1 592 ? 58.067 -8.648 5.716 1.00 33.73 ? 608 THR A CG2 1 ATOM 4837 N N . SER A 1 593 ? 55.845 -10.456 4.029 1.00 34.02 ? 609 SER A N 1 ATOM 4838 C CA . SER A 1 593 ? 55.279 -10.392 2.678 1.00 34.40 ? 609 SER A CA 1 ATOM 4839 C C . SER A 1 593 ? 56.159 -9.607 1.708 1.00 34.84 ? 609 SER A C 1 ATOM 4840 O O . SER A 1 593 ? 56.817 -8.654 2.103 1.00 34.47 ? 609 SER A O 1 ATOM 4841 C CB . SER A 1 593 ? 53.895 -9.744 2.731 1.00 34.34 ? 609 SER A CB 1 ATOM 4842 O OG . SER A 1 593 ? 53.359 -9.550 1.433 1.00 33.64 ? 609 SER A OG 1 ATOM 4843 N N . ASN A 1 594 ? 56.162 -10.017 0.443 1.00 35.69 ? 610 ASN A N 1 ATOM 4844 C CA A ASN A 1 594 ? 56.855 -9.315 -0.636 0.50 36.34 ? 610 ASN A CA 1 ATOM 4845 C CA B ASN A 1 594 ? 56.891 -9.239 -0.571 0.50 36.38 ? 610 ASN A CA 1 ATOM 4846 C C . ASN A 1 594 ? 55.913 -8.544 -1.542 1.00 36.47 ? 610 ASN A C 1 ATOM 4847 O O . ASN A 1 594 ? 56.297 -8.129 -2.643 1.00 36.16 ? 610 ASN A O 1 ATOM 4848 C CB A ASN A 1 594 ? 57.733 -10.317 -1.479 0.50 36.13 ? 610 ASN A CB 1 ATOM 4849 C CB B ASN A 1 594 ? 57.899 -10.148 -1.360 0.50 36.31 ? 610 ASN A CB 1 ATOM 4850 C CG A ASN A 1 594 ? 56.906 -11.280 -2.367 0.50 35.87 ? 610 ASN A CG 1 ATOM 4851 C CG B ASN A 1 594 ? 58.816 -10.978 -0.445 0.50 36.33 ? 610 ASN A CG 1 ATOM 4852 O OD1 A ASN A 1 594 ? 55.685 -11.388 -2.249 0.50 35.80 ? 610 ASN A OD1 1 ATOM 4853 O OD1 B ASN A 1 594 ? 59.577 -10.438 0.362 0.50 36.53 ? 610 ASN A OD1 1 ATOM 4854 N ND2 A ASN A 1 594 ? 57.597 -11.983 -3.258 0.50 35.74 ? 610 ASN A ND2 1 ATOM 4855 N ND2 B ASN A 1 594 ? 58.748 -12.295 -0.591 0.50 36.32 ? 610 ASN A ND2 1 ATOM 4856 N N . LYS A 1 595 ? 54.665 -8.381 -1.096 1.00 36.58 ? 611 LYS A N 1 ATOM 4857 C CA . LYS A 1 595 ? 53.596 -7.835 -1.945 1.00 37.25 ? 611 LYS A CA 1 ATOM 4858 C C . LYS A 1 595 ? 53.361 -6.316 -1.903 1.00 37.84 ? 611 LYS A C 1 ATOM 4859 O O . LYS A 1 595 ? 52.427 -5.816 -2.536 1.00 37.61 ? 611 LYS A O 1 ATOM 4860 C CB . LYS A 1 595 ? 52.282 -8.588 -1.694 1.00 36.91 ? 611 LYS A CB 1 ATOM 4861 C CG . LYS A 1 595 ? 52.286 -10.031 -2.177 1.00 36.79 ? 611 LYS A CG 1 ATOM 4862 C CD . LYS A 1 595 ? 52.446 -10.136 -3.702 1.00 36.49 ? 611 LYS A CD 1 ATOM 4863 C CE . LYS A 1 595 ? 52.202 -11.557 -4.186 1.00 36.39 ? 611 LYS A CE 1 ATOM 4864 N NZ . LYS A 1 595 ? 53.114 -12.537 -3.526 1.00 36.07 ? 611 LYS A NZ 1 ATOM 4865 N N . CYS A 1 596 ? 54.188 -5.585 -1.162 1.00 38.70 ? 612 CYS A N 1 ATOM 4866 C CA . CYS A 1 596 ? 54.143 -4.123 -1.218 1.00 39.84 ? 612 CYS A CA 1 ATOM 4867 C C . CYS A 1 596 ? 55.547 -3.561 -1.363 1.00 40.83 ? 612 CYS A C 1 ATOM 4868 O O . CYS A 1 596 ? 56.340 -3.597 -0.420 1.00 40.83 ? 612 CYS A O 1 ATOM 4869 C CB . CYS A 1 596 ? 53.427 -3.512 -0.004 1.00 39.66 ? 612 CYS A CB 1 ATOM 4870 S SG . CYS A 1 596 ? 52.777 -1.832 -0.309 1.00 38.87 ? 612 CYS A SG 1 ATOM 4871 N N . VAL A 1 597 ? 55.839 -3.058 -2.561 1.00 42.06 ? 613 VAL A N 1 ATOM 4872 C CA . VAL A 1 597 ? 57.142 -2.482 -2.897 1.00 43.43 ? 613 VAL A CA 1 ATOM 4873 C C . VAL A 1 597 ? 57.230 -1.050 -2.378 1.00 44.26 ? 613 VAL A C 1 ATOM 4874 O O . VAL A 1 597 ? 56.386 -0.210 -2.700 1.00 44.38 ? 613 VAL A O 1 ATOM 4875 C CB . VAL A 1 597 ? 57.395 -2.524 -4.437 1.00 43.50 ? 613 VAL A CB 1 ATOM 4876 C CG1 . VAL A 1 597 ? 58.564 -1.615 -4.841 1.00 43.95 ? 613 VAL A CG1 1 ATOM 4877 C CG2 . VAL A 1 597 ? 57.652 -3.949 -4.891 1.00 43.30 ? 613 VAL A CG2 1 ATOM 4878 N N . SER A 1 598 ? 58.252 -0.781 -1.569 1.00 45.52 ? 614 SER A N 1 ATOM 4879 C CA . SER A 1 598 ? 58.423 0.531 -0.945 1.00 46.72 ? 614 SER A CA 1 ATOM 4880 C C . SER A 1 598 ? 59.201 1.487 -1.850 1.00 47.03 ? 614 SER A C 1 ATOM 4881 O O . SER A 1 598 ? 58.837 2.663 -1.980 1.00 47.83 ? 614 SER A O 1 ATOM 4882 C CB . SER A 1 598 ? 59.119 0.398 0.416 1.00 46.91 ? 614 SER A CB 1 ATOM 4883 O OG . SER A 1 598 ? 58.367 -0.420 1.302 1.00 48.54 ? 614 SER A OG 1 ATOM 4884 N N . ARG B 2 6 ? 25.522 9.344 14.311 1.00 46.20 ? 6 ARG P N 1 ATOM 4885 C CA . ARG B 2 6 ? 25.560 8.730 12.945 1.00 46.29 ? 6 ARG P CA 1 ATOM 4886 C C . ARG B 2 6 ? 24.982 7.302 12.949 1.00 45.25 ? 6 ARG P C 1 ATOM 4887 O O . ARG B 2 6 ? 24.907 6.675 14.016 1.00 45.41 ? 6 ARG P O 1 ATOM 4888 C CB . ARG B 2 6 ? 26.997 8.722 12.414 1.00 46.82 ? 6 ARG P CB 1 ATOM 4889 C CG . ARG B 2 6 ? 27.107 9.027 10.919 1.00 49.15 ? 6 ARG P CG 1 ATOM 4890 C CD . ARG B 2 6 ? 28.138 8.135 10.231 1.00 52.39 ? 6 ARG P CD 1 ATOM 4891 N NE . ARG B 2 6 ? 29.450 8.247 10.864 1.00 55.34 ? 6 ARG P NE 1 ATOM 4892 C CZ . ARG B 2 6 ? 30.367 9.158 10.547 1.00 57.06 ? 6 ARG P CZ 1 ATOM 4893 N NH1 . ARG B 2 6 ? 30.130 10.049 9.588 1.00 57.74 ? 6 ARG P NH1 1 ATOM 4894 N NH2 . ARG B 2 6 ? 31.525 9.179 11.194 1.00 57.41 ? 6 ARG P NH2 1 ATOM 4895 N N . PRO B 2 7 ? 24.562 6.785 11.765 1.00 44.16 ? 7 PRO P N 1 ATOM 4896 C CA . PRO B 2 7 ? 24.034 5.421 11.668 1.00 43.12 ? 7 PRO P CA 1 ATOM 4897 C C . PRO B 2 7 ? 25.007 4.347 12.146 1.00 42.10 ? 7 PRO P C 1 ATOM 4898 O O . PRO B 2 7 ? 26.231 4.517 12.058 1.00 41.82 ? 7 PRO P O 1 ATOM 4899 C CB . PRO B 2 7 ? 23.770 5.244 10.160 1.00 43.25 ? 7 PRO P CB 1 ATOM 4900 C CG . PRO B 2 7 ? 24.539 6.338 9.493 1.00 43.74 ? 7 PRO P CG 1 ATOM 4901 C CD . PRO B 2 7 ? 24.441 7.472 10.468 1.00 44.31 ? 7 PRO P CD 1 ATOM 4902 N N . LYS B 2 8 ? 24.443 3.249 12.643 1.00 40.67 ? 8 LYS P N 1 ATOM 4903 C CA . LYS B 2 8 ? 25.212 2.117 13.133 1.00 39.63 ? 8 LYS P CA 1 ATOM 4904 C C . LYS B 2 8 ? 25.247 1.048 12.049 1.00 38.71 ? 8 LYS P C 1 ATOM 4905 O O . LYS B 2 8 ? 24.198 0.637 11.552 1.00 38.44 ? 8 LYS P O 1 ATOM 4906 C CB . LYS B 2 8 ? 24.562 1.554 14.392 1.00 39.67 ? 8 LYS P CB 1 ATOM 4907 C CG . LYS B 2 8 ? 24.206 2.575 15.467 1.00 40.36 ? 8 LYS P CG 1 ATOM 4908 C CD . LYS B 2 8 ? 25.270 2.634 16.548 1.00 41.29 ? 8 LYS P CD 1 ATOM 4909 C CE . LYS B 2 8 ? 26.206 3.796 16.358 1.00 41.96 ? 8 LYS P CE 1 ATOM 4910 N NZ . LYS B 2 8 ? 25.634 5.043 16.921 1.00 41.69 ? 8 LYS P NZ 1 ATOM 4911 N N . ILE B 2 9 ? 26.447 0.592 11.700 1.00 37.57 ? 9 ILE P N 1 ATOM 4912 C CA . ILE B 2 9 ? 26.646 -0.264 10.525 1.00 36.80 ? 9 ILE P CA 1 ATOM 4913 C C . ILE B 2 9 ? 27.365 -1.595 10.848 1.00 36.21 ? 9 ILE P C 1 ATOM 4914 O O . ILE B 2 9 ? 28.068 -1.686 11.858 1.00 36.42 ? 9 ILE P O 1 ATOM 4915 C CB . ILE B 2 9 ? 27.387 0.517 9.399 1.00 36.74 ? 9 ILE P CB 1 ATOM 4916 C CG1 . ILE B 2 9 ? 28.817 0.871 9.818 1.00 36.68 ? 9 ILE P CG1 1 ATOM 4917 C CG2 . ILE B 2 9 ? 26.617 1.788 9.024 1.00 36.33 ? 9 ILE P CG2 1 ATOM 4918 C CD1 . ILE B 2 9 ? 29.641 1.498 8.716 1.00 36.18 ? 9 ILE P CD1 1 ATOM 4919 N N . PRO B 2 10 ? 27.194 -2.632 9.997 1.00 35.52 ? 10 PRO P N 1 ATOM 4920 C CA . PRO B 2 10 ? 27.896 -3.891 10.248 1.00 35.04 ? 10 PRO P CA 1 ATOM 4921 C C . PRO B 2 10 ? 29.398 -3.739 10.011 1.00 34.28 ? 10 PRO P C 1 ATOM 4922 O O . PRO B 2 10 ? 29.814 -2.778 9.350 1.00 34.18 ? 10 PRO P O 1 ATOM 4923 C CB . PRO B 2 10 ? 27.310 -4.852 9.194 1.00 35.05 ? 10 PRO P CB 1 ATOM 4924 C CG . PRO B 2 10 ? 26.191 -4.132 8.549 1.00 35.23 ? 10 PRO P CG 1 ATOM 4925 C CD . PRO B 2 10 ? 26.452 -2.681 8.727 1.00 35.47 ? 10 PRO P CD 1 ATOM 4926 N N . PRO B 2 11 ? 30.211 -4.670 10.551 1.00 33.77 ? 11 PRO P N 1 ATOM 4927 C CA . PRO B 2 11 ? 31.650 -4.652 10.302 1.00 33.51 ? 11 PRO P CA 1 ATOM 4928 C C . PRO B 2 11 ? 31.976 -4.819 8.820 1.00 33.26 ? 11 PRO P C 1 ATOM 4929 O O . PRO B 2 11 ? 33.081 -4.505 8.397 1.00 32.97 ? 11 PRO P O 1 ATOM 4930 C CB . PRO B 2 11 ? 32.164 -5.863 11.087 1.00 33.54 ? 11 PRO P CB 1 ATOM 4931 C CG . PRO B 2 11 ? 30.973 -6.683 11.391 1.00 33.67 ? 11 PRO P CG 1 ATOM 4932 C CD . PRO B 2 11 ? 29.844 -5.727 11.509 1.00 33.71 ? 11 PRO P CD 1 ATOM 4933 O OXT . PRO B 2 11 ? 31.149 -5.265 8.023 1.00 33.04 ? 11 PRO P OXT 1 HETATM 4934 ZN ZN . ZN C 3 . ? 26.588 -2.420 13.553 1.00 55.73 ? 1616 ZN A ZN 1 HETATM 4935 C C1 . NAG D 4 . ? 42.484 23.983 24.777 1.00 38.17 ? 1617 NAG A C1 1 HETATM 4936 C C2 . NAG D 4 . ? 41.174 24.619 25.242 1.00 39.55 ? 1617 NAG A C2 1 HETATM 4937 C C3 . NAG D 4 . ? 41.253 26.142 25.185 1.00 40.43 ? 1617 NAG A C3 1 HETATM 4938 C C4 . NAG D 4 . ? 42.554 26.684 25.790 1.00 40.69 ? 1617 NAG A C4 1 HETATM 4939 C C5 . NAG D 4 . ? 43.779 25.905 25.292 1.00 39.05 ? 1617 NAG A C5 1 HETATM 4940 C C6 . NAG D 4 . ? 45.056 26.338 26.006 1.00 38.63 ? 1617 NAG A C6 1 HETATM 4941 C C7 . NAG D 4 . ? 39.118 23.331 24.860 1.00 41.29 ? 1617 NAG A C7 1 HETATM 4942 C C8 . NAG D 4 . ? 38.053 22.961 23.862 1.00 41.47 ? 1617 NAG A C8 1 HETATM 4943 N N2 . NAG D 4 . ? 40.070 24.157 24.419 1.00 40.60 ? 1617 NAG A N2 1 HETATM 4944 O O3 . NAG D 4 . ? 40.146 26.674 25.875 1.00 39.85 ? 1617 NAG A O3 1 HETATM 4945 O O4 . NAG D 4 . ? 42.673 28.044 25.422 1.00 43.91 ? 1617 NAG A O4 1 HETATM 4946 O O5 . NAG D 4 . ? 43.599 24.511 25.477 1.00 37.77 ? 1617 NAG A O5 1 HETATM 4947 O O6 . NAG D 4 . ? 46.156 25.630 25.484 1.00 38.17 ? 1617 NAG A O6 1 HETATM 4948 O O7 . NAG D 4 . ? 39.080 22.874 26.006 1.00 41.28 ? 1617 NAG A O7 1 HETATM 4949 C C1 . NAG E 4 . ? 42.602 28.932 26.561 1.00 46.50 ? 1618 NAG A C1 1 HETATM 4950 C C2 . NAG E 4 . ? 43.053 30.312 26.087 1.00 48.31 ? 1618 NAG A C2 1 HETATM 4951 C C3 . NAG E 4 . ? 43.035 31.310 27.245 1.00 49.32 ? 1618 NAG A C3 1 HETATM 4952 C C4 . NAG E 4 . ? 41.677 31.335 27.950 1.00 50.13 ? 1618 NAG A C4 1 HETATM 4953 C C5 . NAG E 4 . ? 41.150 29.921 28.220 1.00 49.04 ? 1618 NAG A C5 1 HETATM 4954 C C6 . NAG E 4 . ? 39.665 29.992 28.549 1.00 49.08 ? 1618 NAG A C6 1 HETATM 4955 C C7 . NAG E 4 . ? 45.541 30.034 25.939 1.00 49.83 ? 1618 NAG A C7 1 HETATM 4956 C C8 . NAG E 4 . ? 46.683 30.000 24.966 1.00 49.28 ? 1618 NAG A C8 1 HETATM 4957 N N2 . NAG E 4 . ? 44.336 30.238 25.390 1.00 48.72 ? 1618 NAG A N2 1 HETATM 4958 O O3 . NAG E 4 . ? 43.343 32.592 26.747 1.00 49.21 ? 1618 NAG A O3 1 HETATM 4959 O O4 . NAG E 4 . ? 41.793 31.997 29.197 1.00 53.42 ? 1618 NAG A O4 1 HETATM 4960 O O5 . NAG E 4 . ? 41.308 29.030 27.126 1.00 47.13 ? 1618 NAG A O5 1 HETATM 4961 O O6 . NAG E 4 . ? 39.366 28.984 29.483 1.00 50.98 ? 1618 NAG A O6 1 HETATM 4962 O O7 . NAG E 4 . ? 45.757 29.877 27.150 1.00 50.18 ? 1618 NAG A O7 1 HETATM 4963 C C1 . BMA F 5 . ? 41.375 33.382 29.159 1.00 56.17 ? 1619 BMA A C1 1 HETATM 4964 C C2 . BMA F 5 . ? 40.774 33.776 30.509 1.00 57.18 ? 1619 BMA A C2 1 HETATM 4965 C C3 . BMA F 5 . ? 40.438 35.272 30.571 1.00 58.50 ? 1619 BMA A C3 1 HETATM 4966 C C4 . BMA F 5 . ? 41.604 36.144 30.105 1.00 58.96 ? 1619 BMA A C4 1 HETATM 4967 C C5 . BMA F 5 . ? 42.170 35.643 28.774 1.00 59.93 ? 1619 BMA A C5 1 HETATM 4968 C C6 . BMA F 5 . ? 43.436 36.409 28.393 1.00 62.15 ? 1619 BMA A C6 1 HETATM 4969 O O2 . BMA F 5 . ? 41.693 33.436 31.558 1.00 55.88 ? 1619 BMA A O2 1 HETATM 4970 O O3 . BMA F 5 . ? 40.080 35.654 31.909 1.00 60.04 ? 1619 BMA A O3 1 HETATM 4971 O O4 . BMA F 5 . ? 41.151 37.492 29.961 1.00 58.79 ? 1619 BMA A O4 1 HETATM 4972 O O5 . BMA F 5 . ? 42.476 34.243 28.855 1.00 57.99 ? 1619 BMA A O5 1 HETATM 4973 O O6 . BMA F 5 . ? 44.236 35.607 27.513 1.00 64.81 ? 1619 BMA A O6 1 HETATM 4974 C C1 . MAN G 6 . ? 44.784 36.431 26.466 1.00 66.77 ? 1620 MAN A C1 1 HETATM 4975 C C2 . MAN G 6 . ? 44.358 35.899 25.089 1.00 67.84 ? 1620 MAN A C2 1 HETATM 4976 C C3 . MAN G 6 . ? 45.202 34.699 24.639 1.00 68.41 ? 1620 MAN A C3 1 HETATM 4977 C C4 . MAN G 6 . ? 46.694 34.932 24.868 1.00 68.35 ? 1620 MAN A C4 1 HETATM 4978 C C5 . MAN G 6 . ? 46.971 35.431 26.292 1.00 68.33 ? 1620 MAN A C5 1 HETATM 4979 C C6 . MAN G 6 . ? 48.448 35.776 26.486 1.00 68.66 ? 1620 MAN A C6 1 HETATM 4980 O O2 . MAN G 6 . ? 44.437 36.936 24.135 1.00 68.81 ? 1620 MAN A O2 1 HETATM 4981 O O3 . MAN G 6 . ? 44.985 34.405 23.272 1.00 68.68 ? 1620 MAN A O3 1 HETATM 4982 O O4 . MAN G 6 . ? 47.361 33.718 24.617 1.00 68.46 ? 1620 MAN A O4 1 HETATM 4983 O O5 . MAN G 6 . ? 46.192 36.588 26.569 1.00 67.52 ? 1620 MAN A O5 1 HETATM 4984 O O6 . MAN G 6 . ? 48.707 36.064 27.845 1.00 68.90 ? 1620 MAN A O6 1 HETATM 4985 C C1 . MAN H 6 . ? 38.649 35.829 32.015 1.00 60.83 ? 1623 MAN A C1 1 HETATM 4986 C C2 . MAN H 6 . ? 38.312 36.936 33.015 1.00 61.16 ? 1623 MAN A C2 1 HETATM 4987 C C3 . MAN H 6 . ? 38.663 36.491 34.434 1.00 61.49 ? 1623 MAN A C3 1 HETATM 4988 C C4 . MAN H 6 . ? 38.057 35.129 34.781 1.00 61.65 ? 1623 MAN A C4 1 HETATM 4989 C C5 . MAN H 6 . ? 38.142 34.095 33.648 1.00 62.12 ? 1623 MAN A C5 1 HETATM 4990 C C6 . MAN H 6 . ? 37.032 33.071 33.838 1.00 63.44 ? 1623 MAN A C6 1 HETATM 4991 O O2 . MAN H 6 . ? 36.938 37.262 32.932 1.00 61.14 ? 1623 MAN A O2 1 HETATM 4992 O O3 . MAN H 6 . ? 38.212 37.459 35.359 1.00 61.71 ? 1623 MAN A O3 1 HETATM 4993 O O4 . MAN H 6 . ? 38.701 34.624 35.930 1.00 61.14 ? 1623 MAN A O4 1 HETATM 4994 O O5 . MAN H 6 . ? 37.962 34.631 32.343 1.00 61.52 ? 1623 MAN A O5 1 HETATM 4995 O O6 . MAN H 6 . ? 37.587 31.886 34.350 1.00 65.37 ? 1623 MAN A O6 1 HETATM 4996 C C1 . BMA I 5 . ? 36.678 31.125 35.187 1.00 66.97 ? 1624 BMA A C1 1 HETATM 4997 C C2 . BMA I 5 . ? 37.402 30.751 36.494 1.00 67.33 ? 1624 BMA A C2 1 HETATM 4998 C C3 . BMA I 5 . ? 36.609 31.070 37.753 1.00 67.73 ? 1624 BMA A C3 1 HETATM 4999 C C4 . BMA I 5 . ? 35.906 32.405 37.581 1.00 68.02 ? 1624 BMA A C4 1 HETATM 5000 C C5 . BMA I 5 . ? 34.826 32.225 36.514 1.00 68.44 ? 1624 BMA A C5 1 HETATM 5001 C C6 . BMA I 5 . ? 34.144 33.546 36.173 1.00 69.08 ? 1624 BMA A C6 1 HETATM 5002 O O2 . BMA I 5 . ? 38.664 31.424 36.566 1.00 68.61 ? 1624 BMA A O2 1 HETATM 5003 O O3 . BMA I 5 . ? 37.472 31.055 38.897 1.00 66.82 ? 1624 BMA A O3 1 HETATM 5004 O O4 . BMA I 5 . ? 35.322 32.801 38.826 1.00 68.49 ? 1624 BMA A O4 1 HETATM 5005 O O5 . BMA I 5 . ? 35.313 31.610 35.299 1.00 67.87 ? 1624 BMA A O5 1 HETATM 5006 O O6 . BMA I 5 . ? 33.054 33.752 37.080 1.00 69.86 ? 1624 BMA A O6 1 HETATM 5007 C C1 . NAG J 4 . ? 8.559 -8.429 30.815 0.80 50.37 ? 1621 NAG A C1 1 HETATM 5008 C C2 . NAG J 4 . ? 8.627 -9.213 32.131 0.80 52.90 ? 1621 NAG A C2 1 HETATM 5009 C C3 . NAG J 4 . ? 7.934 -8.458 33.270 0.80 53.73 ? 1621 NAG A C3 1 HETATM 5010 C C4 . NAG J 4 . ? 8.461 -7.026 33.344 0.80 53.67 ? 1621 NAG A C4 1 HETATM 5011 C C5 . NAG J 4 . ? 8.273 -6.366 31.975 0.80 53.25 ? 1621 NAG A C5 1 HETATM 5012 C C6 . NAG J 4 . ? 8.656 -4.885 31.984 0.80 53.55 ? 1621 NAG A C6 1 HETATM 5013 C C7 . NAG J 4 . ? 8.657 -11.634 32.422 0.80 54.11 ? 1621 NAG A C7 1 HETATM 5014 C C8 . NAG J 4 . ? 7.969 -12.936 32.133 0.80 54.48 ? 1621 NAG A C8 1 HETATM 5015 N N2 . NAG J 4 . ? 8.067 -10.541 31.939 0.80 53.38 ? 1621 NAG A N2 1 HETATM 5016 O O3 . NAG J 4 . ? 8.135 -9.112 34.507 0.80 54.51 ? 1621 NAG A O3 1 HETATM 5017 O O4 . NAG J 4 . ? 7.789 -6.312 34.361 0.80 54.63 ? 1621 NAG A O4 1 HETATM 5018 O O5 . NAG J 4 . ? 9.015 -7.097 31.004 0.80 51.68 ? 1621 NAG A O5 1 HETATM 5019 O O6 . NAG J 4 . ? 9.797 -4.637 31.189 0.80 54.16 ? 1621 NAG A O6 1 HETATM 5020 O O7 . NAG J 4 . ? 9.705 -11.615 33.075 0.80 54.35 ? 1621 NAG A O7 1 HETATM 5021 C C1 . NAG K 4 . ? 16.548 11.161 -5.770 0.80 54.90 ? 1622 NAG A C1 1 HETATM 5022 C C2 . NAG K 4 . ? 15.159 10.894 -6.356 0.80 56.72 ? 1622 NAG A C2 1 HETATM 5023 C C3 . NAG K 4 . ? 14.988 11.659 -7.669 0.80 57.38 ? 1622 NAG A C3 1 HETATM 5024 C C4 . NAG K 4 . ? 15.223 13.148 -7.422 0.80 57.77 ? 1622 NAG A C4 1 HETATM 5025 C C5 . NAG K 4 . ? 16.600 13.338 -6.773 0.80 57.66 ? 1622 NAG A C5 1 HETATM 5026 C C6 . NAG K 4 . ? 16.895 14.799 -6.444 0.80 58.03 ? 1622 NAG A C6 1 HETATM 5027 C C7 . NAG K 4 . ? 14.214 8.744 -5.682 0.80 57.14 ? 1622 NAG A C7 1 HETATM 5028 C C8 . NAG K 4 . ? 14.035 7.301 -6.045 0.80 57.26 ? 1622 NAG A C8 1 HETATM 5029 N N2 . NAG K 4 . ? 14.907 9.478 -6.554 0.80 56.98 ? 1622 NAG A N2 1 HETATM 5030 O O3 . NAG K 4 . ? 13.697 11.451 -8.188 0.80 57.46 ? 1622 NAG A O3 1 HETATM 5031 O O4 . NAG K 4 . ? 15.134 13.854 -8.640 0.80 58.44 ? 1622 NAG A O4 1 HETATM 5032 O O5 . NAG K 4 . ? 16.693 12.563 -5.586 0.80 56.28 ? 1622 NAG A O5 1 HETATM 5033 O O6 . NAG K 4 . ? 18.291 14.983 -6.352 0.80 58.22 ? 1622 NAG A O6 1 HETATM 5034 O O7 . NAG K 4 . ? 13.739 9.181 -4.632 0.80 57.22 ? 1622 NAG A O7 1 HETATM 5035 O O . HOH L 7 . ? 25.571 23.745 43.516 1.00 50.19 ? 2001 HOH A O 1 HETATM 5036 O O . HOH L 7 . ? 18.839 16.905 30.997 1.00 35.05 ? 2002 HOH A O 1 HETATM 5037 O O . HOH L 7 . ? 15.506 16.775 27.823 1.00 49.21 ? 2003 HOH A O 1 HETATM 5038 O O . HOH L 7 . ? 11.644 17.619 13.345 1.00 46.27 ? 2004 HOH A O 1 HETATM 5039 O O . HOH L 7 . ? 19.624 20.743 12.431 1.00 41.17 ? 2005 HOH A O 1 HETATM 5040 O O . HOH L 7 . ? 20.585 23.574 13.682 1.00 45.23 ? 2006 HOH A O 1 HETATM 5041 O O . HOH L 7 . ? 23.528 28.689 11.103 1.00 46.43 ? 2007 HOH A O 1 HETATM 5042 O O . HOH L 7 . ? 11.792 11.855 11.635 1.00 36.42 ? 2008 HOH A O 1 HETATM 5043 O O . HOH L 7 . ? 16.061 17.438 6.927 1.00 41.81 ? 2009 HOH A O 1 HETATM 5044 O O . HOH L 7 . ? 15.917 15.551 4.101 1.00 48.48 ? 2010 HOH A O 1 HETATM 5045 O O . HOH L 7 . ? 20.005 15.140 1.562 1.00 45.34 ? 2011 HOH A O 1 HETATM 5046 O O . HOH L 7 . ? 24.359 9.763 4.335 1.00 42.02 ? 2012 HOH A O 1 HETATM 5047 O O . HOH L 7 . ? 13.320 7.078 2.031 1.00 50.33 ? 2013 HOH A O 1 HETATM 5048 O O . HOH L 7 . ? 27.634 12.695 -4.075 1.00 42.10 ? 2014 HOH A O 1 HETATM 5049 O O . HOH L 7 . ? 29.665 26.255 5.547 1.00 45.91 ? 2015 HOH A O 1 HETATM 5050 O O . HOH L 7 . ? 21.248 16.574 -8.153 1.00 50.84 ? 2016 HOH A O 1 HETATM 5051 O O . HOH L 7 . ? 23.679 14.036 -9.211 1.00 44.93 ? 2017 HOH A O 1 HETATM 5052 O O . HOH L 7 . ? 28.887 -1.195 -1.650 1.00 47.72 ? 2018 HOH A O 1 HETATM 5053 O O . HOH L 7 . ? 31.971 16.100 -2.408 1.00 44.39 ? 2019 HOH A O 1 HETATM 5054 O O . HOH L 7 . ? 29.527 14.785 4.435 1.00 36.97 ? 2020 HOH A O 1 HETATM 5055 O O . HOH L 7 . ? 27.194 24.324 -1.028 1.00 55.37 ? 2021 HOH A O 1 HETATM 5056 O O . HOH L 7 . ? 20.363 -6.388 -6.867 1.00 50.03 ? 2022 HOH A O 1 HETATM 5057 O O . HOH L 7 . ? 27.828 -8.517 3.986 1.00 40.80 ? 2023 HOH A O 1 HETATM 5058 O O . HOH L 7 . ? 29.331 25.685 10.099 1.00 41.89 ? 2024 HOH A O 1 HETATM 5059 O O . HOH L 7 . ? 23.021 27.370 13.359 1.00 42.10 ? 2025 HOH A O 1 HETATM 5060 O O . HOH L 7 . ? 45.272 2.536 -10.102 1.00 40.82 ? 2026 HOH A O 1 HETATM 5061 O O . HOH L 7 . ? 30.592 26.655 12.360 1.00 46.28 ? 2027 HOH A O 1 HETATM 5062 O O . HOH L 7 . ? 48.255 17.783 9.847 1.00 40.35 ? 2028 HOH A O 1 HETATM 5063 O O . HOH L 7 . ? 47.715 15.338 8.984 1.00 44.43 ? 2029 HOH A O 1 HETATM 5064 O O . HOH L 7 . ? 50.652 14.681 11.458 1.00 46.33 ? 2030 HOH A O 1 HETATM 5065 O O . HOH L 7 . ? 46.310 22.085 14.046 1.00 38.68 ? 2031 HOH A O 1 HETATM 5066 O O . HOH L 7 . ? 41.450 27.002 13.908 1.00 51.88 ? 2032 HOH A O 1 HETATM 5067 O O . HOH L 7 . ? 32.818 23.867 29.545 1.00 48.46 ? 2033 HOH A O 1 HETATM 5068 O O . HOH L 7 . ? 43.564 11.684 25.440 1.00 35.96 ? 2034 HOH A O 1 HETATM 5069 O O . HOH L 7 . ? 32.836 26.106 33.327 1.00 36.94 ? 2035 HOH A O 1 HETATM 5070 O O . HOH L 7 . ? 43.210 7.732 25.242 1.00 39.70 ? 2036 HOH A O 1 HETATM 5071 O O . HOH L 7 . ? 33.532 25.297 37.893 1.00 39.57 ? 2037 HOH A O 1 HETATM 5072 O O . HOH L 7 . ? 33.656 24.385 35.375 1.00 34.31 ? 2038 HOH A O 1 HETATM 5073 O O . HOH L 7 . ? 48.839 2.501 25.727 1.00 37.52 ? 2039 HOH A O 1 HETATM 5074 O O . HOH L 7 . ? 43.069 -9.097 30.180 1.00 36.23 ? 2040 HOH A O 1 HETATM 5075 O O . HOH L 7 . ? 50.974 -7.086 23.740 1.00 42.16 ? 2041 HOH A O 1 HETATM 5076 O O . HOH L 7 . ? 52.458 -3.681 21.004 1.00 58.58 ? 2042 HOH A O 1 HETATM 5077 O O . HOH L 7 . ? 29.580 14.635 42.999 1.00 49.58 ? 2043 HOH A O 1 HETATM 5078 O O . HOH L 7 . ? 51.638 -11.402 21.609 1.00 43.22 ? 2044 HOH A O 1 HETATM 5079 O O . HOH L 7 . ? 45.839 -20.510 22.769 1.00 46.11 ? 2045 HOH A O 1 HETATM 5080 O O . HOH L 7 . ? 52.411 -11.038 24.448 1.00 50.78 ? 2046 HOH A O 1 HETATM 5081 O O . HOH L 7 . ? 20.626 15.613 39.538 1.00 53.19 ? 2047 HOH A O 1 HETATM 5082 O O . HOH L 7 . ? 21.300 13.138 40.193 1.00 63.32 ? 2048 HOH A O 1 HETATM 5083 O O . HOH L 7 . ? 23.837 12.174 40.173 1.00 47.27 ? 2049 HOH A O 1 HETATM 5084 O O . HOH L 7 . ? 30.248 12.872 36.385 1.00 49.69 ? 2050 HOH A O 1 HETATM 5085 O O . HOH L 7 . ? 33.089 14.970 38.292 1.00 38.88 ? 2051 HOH A O 1 HETATM 5086 O O . HOH L 7 . ? 50.625 -26.770 19.783 1.00 39.03 ? 2052 HOH A O 1 HETATM 5087 O O . HOH L 7 . ? 51.961 -26.752 16.440 1.00 41.49 ? 2053 HOH A O 1 HETATM 5088 O O . HOH L 7 . ? 54.366 -28.220 17.902 1.00 55.22 ? 2054 HOH A O 1 HETATM 5089 O O . HOH L 7 . ? 25.803 10.021 36.811 1.00 46.42 ? 2055 HOH A O 1 HETATM 5090 O O . HOH L 7 . ? 19.490 12.118 33.673 1.00 48.23 ? 2056 HOH A O 1 HETATM 5091 O O . HOH L 7 . ? 23.856 9.716 34.977 1.00 41.27 ? 2057 HOH A O 1 HETATM 5092 O O . HOH L 7 . ? 19.808 15.046 37.088 1.00 42.39 ? 2058 HOH A O 1 HETATM 5093 O O . HOH L 7 . ? 31.800 14.811 34.035 1.00 48.65 ? 2059 HOH A O 1 HETATM 5094 O O . HOH L 7 . ? 27.682 10.445 28.634 1.00 47.82 ? 2060 HOH A O 1 HETATM 5095 O O . HOH L 7 . ? 30.359 10.415 34.509 1.00 46.25 ? 2061 HOH A O 1 HETATM 5096 O O . HOH L 7 . ? 28.401 5.624 28.860 1.00 28.28 ? 2062 HOH A O 1 HETATM 5097 O O . HOH L 7 . ? 35.498 17.693 28.190 1.00 46.17 ? 2063 HOH A O 1 HETATM 5098 O O . HOH L 7 . ? 33.422 10.019 26.543 1.00 43.37 ? 2064 HOH A O 1 HETATM 5099 O O . HOH L 7 . ? 35.501 16.708 20.888 1.00 45.57 ? 2065 HOH A O 1 HETATM 5100 O O . HOH L 7 . ? 32.878 14.884 15.096 1.00 44.99 ? 2066 HOH A O 1 HETATM 5101 O O . HOH L 7 . ? 35.577 14.158 15.924 1.00 43.71 ? 2067 HOH A O 1 HETATM 5102 O O . HOH L 7 . ? 35.238 10.085 12.865 1.00 38.03 ? 2068 HOH A O 1 HETATM 5103 O O . HOH L 7 . ? 36.012 11.775 14.817 1.00 42.50 ? 2069 HOH A O 1 HETATM 5104 O O . HOH L 7 . ? 36.734 25.777 18.041 1.00 43.67 ? 2070 HOH A O 1 HETATM 5105 O O . HOH L 7 . ? 34.282 29.777 11.928 1.00 46.01 ? 2071 HOH A O 1 HETATM 5106 O O . HOH L 7 . ? 30.510 25.164 7.856 1.00 40.26 ? 2072 HOH A O 1 HETATM 5107 O O . HOH L 7 . ? 28.005 28.474 9.193 1.00 49.91 ? 2073 HOH A O 1 HETATM 5108 O O . HOH L 7 . ? 35.072 25.438 2.666 1.00 44.37 ? 2074 HOH A O 1 HETATM 5109 O O . HOH L 7 . ? 39.119 25.127 4.507 1.00 45.53 ? 2075 HOH A O 1 HETATM 5110 O O . HOH L 7 . ? 20.434 -27.264 1.531 1.00 45.11 ? 2076 HOH A O 1 HETATM 5111 O O . HOH L 7 . ? 21.897 -27.308 -0.683 1.00 53.24 ? 2077 HOH A O 1 HETATM 5112 O O . HOH L 7 . ? 30.190 21.198 2.548 1.00 44.18 ? 2078 HOH A O 1 HETATM 5113 O O . HOH L 7 . ? 7.923 -9.558 0.655 1.00 52.03 ? 2079 HOH A O 1 HETATM 5114 O O . HOH L 7 . ? 5.296 -4.784 7.050 1.00 48.09 ? 2080 HOH A O 1 HETATM 5115 O O . HOH L 7 . ? 35.681 21.654 -0.722 1.00 54.81 ? 2081 HOH A O 1 HETATM 5116 O O . HOH L 7 . ? 5.639 -7.672 22.248 1.00 53.13 ? 2082 HOH A O 1 HETATM 5117 O O . HOH L 7 . ? 33.744 11.099 -5.327 1.00 38.43 ? 2083 HOH A O 1 HETATM 5118 O O . HOH L 7 . ? 36.198 4.897 -1.975 1.00 31.01 ? 2084 HOH A O 1 HETATM 5119 O O . HOH L 7 . ? 11.583 0.933 -0.106 1.00 49.75 ? 2085 HOH A O 1 HETATM 5120 O O . HOH L 7 . ? 31.672 10.025 -6.849 1.00 44.20 ? 2086 HOH A O 1 HETATM 5121 O O . HOH L 7 . ? 33.117 5.360 -7.954 1.00 35.33 ? 2087 HOH A O 1 HETATM 5122 O O . HOH L 7 . ? 36.512 4.978 -8.575 1.00 41.65 ? 2088 HOH A O 1 HETATM 5123 O O . HOH L 7 . ? 31.463 -0.399 -3.403 1.00 36.68 ? 2089 HOH A O 1 HETATM 5124 O O . HOH L 7 . ? 25.467 3.123 -5.985 1.00 43.22 ? 2090 HOH A O 1 HETATM 5125 O O . HOH L 7 . ? 30.039 -0.961 -5.699 1.00 34.65 ? 2091 HOH A O 1 HETATM 5126 O O . HOH L 7 . ? 36.522 -3.016 -14.484 1.00 44.17 ? 2092 HOH A O 1 HETATM 5127 O O . HOH L 7 . ? 40.394 -17.860 -14.966 1.00 36.50 ? 2093 HOH A O 1 HETATM 5128 O O . HOH L 7 . ? 27.605 -19.840 11.918 1.00 37.12 ? 2094 HOH A O 1 HETATM 5129 O O . HOH L 7 . ? 27.100 -8.958 11.373 1.00 48.48 ? 2095 HOH A O 1 HETATM 5130 O O . HOH L 7 . ? 22.147 -6.664 -2.311 1.00 40.86 ? 2096 HOH A O 1 HETATM 5131 O O . HOH L 7 . ? 26.725 -8.605 -1.310 1.00 37.17 ? 2097 HOH A O 1 HETATM 5132 O O . HOH L 7 . ? 23.834 -6.782 1.028 1.00 34.46 ? 2098 HOH A O 1 HETATM 5133 O O . HOH L 7 . ? 26.814 -4.466 1.570 1.00 35.11 ? 2099 HOH A O 1 HETATM 5134 O O . HOH L 7 . ? 26.701 -10.678 -3.009 1.00 39.76 ? 2100 HOH A O 1 HETATM 5135 O O . HOH L 7 . ? 28.446 -11.465 -9.850 1.00 44.21 ? 2101 HOH A O 1 HETATM 5136 O O . HOH L 7 . ? 23.075 -9.078 -9.845 1.00 45.05 ? 2102 HOH A O 1 HETATM 5137 O O . HOH L 7 . ? 22.209 -5.145 -8.385 1.00 48.06 ? 2103 HOH A O 1 HETATM 5138 O O . HOH L 7 . ? 28.264 -12.351 -1.528 1.00 44.40 ? 2104 HOH A O 1 HETATM 5139 O O . HOH L 7 . ? 32.224 -12.163 0.097 1.00 49.45 ? 2105 HOH A O 1 HETATM 5140 O O . HOH L 7 . ? 27.270 -7.456 1.750 1.00 45.11 ? 2106 HOH A O 1 HETATM 5141 O O . HOH L 7 . ? 33.408 -9.722 0.357 1.00 30.83 ? 2107 HOH A O 1 HETATM 5142 O O . HOH L 7 . ? 30.764 -9.046 2.972 1.00 44.46 ? 2108 HOH A O 1 HETATM 5143 O O . HOH L 7 . ? 30.378 -5.768 3.267 1.00 38.43 ? 2109 HOH A O 1 HETATM 5144 O O . HOH L 7 . ? 37.696 -15.865 -2.157 1.00 33.65 ? 2110 HOH A O 1 HETATM 5145 O O . HOH L 7 . ? 30.863 -20.341 -0.550 1.00 54.41 ? 2111 HOH A O 1 HETATM 5146 O O . HOH L 7 . ? 31.975 -21.038 -7.815 1.00 55.42 ? 2112 HOH A O 1 HETATM 5147 O O . HOH L 7 . ? 25.341 -18.998 1.150 1.00 52.71 ? 2113 HOH A O 1 HETATM 5148 O O . HOH L 7 . ? 33.962 -19.396 -11.242 1.00 49.34 ? 2114 HOH A O 1 HETATM 5149 O O . HOH L 7 . ? 34.859 -21.224 -9.265 1.00 42.95 ? 2115 HOH A O 1 HETATM 5150 O O . HOH L 7 . ? 45.803 -16.217 -7.636 1.00 44.33 ? 2116 HOH A O 1 HETATM 5151 O O . HOH L 7 . ? 43.672 -12.301 -13.002 1.00 42.01 ? 2117 HOH A O 1 HETATM 5152 O O . HOH L 7 . ? 43.011 -18.373 -15.678 1.00 43.17 ? 2118 HOH A O 1 HETATM 5153 O O . HOH L 7 . ? 40.529 -10.562 -0.521 1.00 32.21 ? 2119 HOH A O 1 HETATM 5154 O O . HOH L 7 . ? 51.256 1.290 13.920 1.00 37.01 ? 2120 HOH A O 1 HETATM 5155 O O . HOH L 7 . ? 51.545 0.307 19.144 1.00 51.07 ? 2121 HOH A O 1 HETATM 5156 O O . HOH L 7 . ? 44.250 -7.817 -13.555 1.00 48.73 ? 2122 HOH A O 1 HETATM 5157 O O . HOH L 7 . ? 46.376 -2.164 -10.494 1.00 43.76 ? 2123 HOH A O 1 HETATM 5158 O O . HOH L 7 . ? 49.064 -3.777 -8.318 1.00 34.86 ? 2124 HOH A O 1 HETATM 5159 O O . HOH L 7 . ? 50.383 -8.138 -11.327 1.00 47.77 ? 2125 HOH A O 1 HETATM 5160 O O . HOH L 7 . ? 41.576 -4.627 2.801 1.00 30.97 ? 2126 HOH A O 1 HETATM 5161 O O . HOH L 7 . ? 55.073 1.231 8.887 1.00 53.19 ? 2127 HOH A O 1 HETATM 5162 O O . HOH L 7 . ? 42.212 4.257 -9.416 1.00 49.52 ? 2128 HOH A O 1 HETATM 5163 O O . HOH L 7 . ? 45.808 1.226 -7.767 1.00 31.33 ? 2129 HOH A O 1 HETATM 5164 O O . HOH L 7 . ? 41.122 10.160 -8.532 1.00 50.30 ? 2130 HOH A O 1 HETATM 5165 O O . HOH L 7 . ? 43.456 10.976 -5.487 1.00 48.93 ? 2131 HOH A O 1 HETATM 5166 O O . HOH L 7 . ? 47.559 14.211 5.085 1.00 47.43 ? 2132 HOH A O 1 HETATM 5167 O O . HOH L 7 . ? 33.416 8.035 16.176 1.00 39.72 ? 2133 HOH A O 1 HETATM 5168 O O . HOH L 7 . ? 38.662 6.599 7.793 1.00 25.87 ? 2134 HOH A O 1 HETATM 5169 O O . HOH L 7 . ? 46.108 19.262 10.286 1.00 38.39 ? 2135 HOH A O 1 HETATM 5170 O O . HOH L 7 . ? 39.408 14.241 15.213 1.00 34.51 ? 2136 HOH A O 1 HETATM 5171 O O . HOH L 7 . ? 38.932 11.411 15.157 1.00 29.31 ? 2137 HOH A O 1 HETATM 5172 O O . HOH L 7 . ? 44.077 12.978 13.673 1.00 35.08 ? 2138 HOH A O 1 HETATM 5173 O O . HOH L 7 . ? 48.137 13.499 11.125 1.00 36.58 ? 2139 HOH A O 1 HETATM 5174 O O . HOH L 7 . ? 46.684 19.701 12.976 1.00 40.67 ? 2140 HOH A O 1 HETATM 5175 O O . HOH L 7 . ? 43.940 22.588 15.531 1.00 32.12 ? 2141 HOH A O 1 HETATM 5176 O O . HOH L 7 . ? 42.290 28.217 11.478 1.00 49.06 ? 2142 HOH A O 1 HETATM 5177 O O . HOH L 7 . ? 44.171 23.166 20.793 1.00 31.53 ? 2143 HOH A O 1 HETATM 5178 O O . HOH L 7 . ? 37.475 15.822 16.399 1.00 36.78 ? 2144 HOH A O 1 HETATM 5179 O O . HOH L 7 . ? 37.528 15.795 19.002 1.00 40.53 ? 2145 HOH A O 1 HETATM 5180 O O . HOH L 7 . ? 45.111 13.650 23.865 1.00 32.72 ? 2146 HOH A O 1 HETATM 5181 O O . HOH L 7 . ? 48.756 14.428 15.309 1.00 39.11 ? 2147 HOH A O 1 HETATM 5182 O O . HOH L 7 . ? 48.603 16.665 22.757 1.00 46.00 ? 2148 HOH A O 1 HETATM 5183 O O . HOH L 7 . ? 41.681 9.928 24.523 1.00 31.21 ? 2149 HOH A O 1 HETATM 5184 O O . HOH L 7 . ? 49.429 10.143 21.041 1.00 40.92 ? 2150 HOH A O 1 HETATM 5185 O O . HOH L 7 . ? 47.567 8.927 23.581 1.00 41.08 ? 2151 HOH A O 1 HETATM 5186 O O . HOH L 7 . ? 21.890 3.504 36.547 1.00 51.70 ? 2152 HOH A O 1 HETATM 5187 O O . HOH L 7 . ? 35.374 5.509 19.417 1.00 31.34 ? 2153 HOH A O 1 HETATM 5188 O O . HOH L 7 . ? 39.391 6.624 26.924 1.00 35.42 ? 2154 HOH A O 1 HETATM 5189 O O . HOH L 7 . ? 36.619 10.752 28.944 1.00 59.94 ? 2155 HOH A O 1 HETATM 5190 O O . HOH L 7 . ? 31.331 9.781 24.861 1.00 57.60 ? 2156 HOH A O 1 HETATM 5191 O O . HOH L 7 . ? 35.239 3.447 32.036 1.00 40.05 ? 2157 HOH A O 1 HETATM 5192 O O . HOH L 7 . ? 37.930 5.375 33.505 1.00 51.51 ? 2158 HOH A O 1 HETATM 5193 O O . HOH L 7 . ? 31.769 4.863 28.822 1.00 41.19 ? 2159 HOH A O 1 HETATM 5194 O O . HOH L 7 . ? 37.273 -23.356 29.530 1.00 45.48 ? 2160 HOH A O 1 HETATM 5195 O O . HOH L 7 . ? 42.313 5.323 25.980 1.00 37.12 ? 2161 HOH A O 1 HETATM 5196 O O . HOH L 7 . ? 41.871 3.733 33.394 1.00 48.83 ? 2162 HOH A O 1 HETATM 5197 O O . HOH L 7 . ? 36.864 1.185 32.515 1.00 33.00 ? 2163 HOH A O 1 HETATM 5198 O O . HOH L 7 . ? 35.853 -26.677 27.450 1.00 49.39 ? 2164 HOH A O 1 HETATM 5199 O O . HOH L 7 . ? 40.700 6.628 32.760 1.00 48.45 ? 2165 HOH A O 1 HETATM 5200 O O . HOH L 7 . ? 44.715 3.895 25.915 1.00 30.69 ? 2166 HOH A O 1 HETATM 5201 O O . HOH L 7 . ? 46.603 2.337 27.210 1.00 31.62 ? 2167 HOH A O 1 HETATM 5202 O O . HOH L 7 . ? 48.823 -33.246 20.445 1.00 46.02 ? 2168 HOH A O 1 HETATM 5203 O O . HOH L 7 . ? 48.994 4.609 23.156 1.00 49.83 ? 2169 HOH A O 1 HETATM 5204 O O . HOH L 7 . ? 48.173 2.118 20.372 1.00 37.93 ? 2170 HOH A O 1 HETATM 5205 O O . HOH L 7 . ? 49.524 0.346 24.199 1.00 40.58 ? 2171 HOH A O 1 HETATM 5206 O O . HOH L 7 . ? 42.768 -6.480 29.490 1.00 33.16 ? 2172 HOH A O 1 HETATM 5207 O O . HOH L 7 . ? 40.573 -5.350 30.324 1.00 32.22 ? 2173 HOH A O 1 HETATM 5208 O O . HOH L 7 . ? 37.983 -3.247 31.732 1.00 30.71 ? 2174 HOH A O 1 HETATM 5209 O O . HOH L 7 . ? 58.389 -7.247 -6.925 1.00 36.93 ? 2175 HOH A O 1 HETATM 5210 O O . HOH L 7 . ? 48.907 -7.401 21.763 1.00 34.17 ? 2176 HOH A O 1 HETATM 5211 O O . HOH L 7 . ? 50.567 -5.090 19.220 1.00 34.67 ? 2177 HOH A O 1 HETATM 5212 O O . HOH L 7 . ? 48.816 -0.159 21.701 1.00 38.14 ? 2178 HOH A O 1 HETATM 5213 O O . HOH L 7 . ? 45.303 -10.330 29.673 1.00 44.59 ? 2179 HOH A O 1 HETATM 5214 O O . HOH L 7 . ? 48.318 -10.678 27.554 1.00 41.11 ? 2180 HOH A O 1 HETATM 5215 O O . HOH L 7 . ? 44.981 -5.767 30.988 1.00 41.17 ? 2181 HOH A O 1 HETATM 5216 O O . HOH L 7 . ? 50.438 -13.613 21.858 1.00 33.39 ? 2182 HOH A O 1 HETATM 5217 O O . HOH L 7 . ? 49.769 -13.644 26.409 1.00 55.12 ? 2183 HOH A O 1 HETATM 5218 O O . HOH L 7 . ? 42.745 -17.049 25.192 1.00 49.61 ? 2184 HOH A O 1 HETATM 5219 O O . HOH L 7 . ? 44.761 -18.254 22.353 1.00 42.62 ? 2185 HOH A O 1 HETATM 5220 O O . HOH L 7 . ? 42.274 -12.666 27.757 1.00 38.45 ? 2186 HOH A O 1 HETATM 5221 O O . HOH L 7 . ? 49.035 -12.664 14.579 1.00 35.86 ? 2187 HOH A O 1 HETATM 5222 O O . HOH L 7 . ? 50.125 -9.523 20.538 1.00 36.62 ? 2188 HOH A O 1 HETATM 5223 O O . HOH L 7 . ? 49.771 -20.746 18.149 1.00 35.07 ? 2189 HOH A O 1 HETATM 5224 O O . HOH L 7 . ? 42.757 -11.898 10.287 1.00 28.51 ? 2190 HOH A O 1 HETATM 5225 O O . HOH L 7 . ? 49.956 -19.622 11.119 1.00 27.07 ? 2191 HOH A O 1 HETATM 5226 O O . HOH L 7 . ? 49.588 -27.197 17.468 1.00 35.23 ? 2192 HOH A O 1 HETATM 5227 O O . HOH L 7 . ? 49.212 -21.940 20.410 1.00 35.96 ? 2193 HOH A O 1 HETATM 5228 O O . HOH L 7 . ? 50.259 -23.862 7.369 1.00 28.54 ? 2194 HOH A O 1 HETATM 5229 O O . HOH L 7 . ? 42.704 -32.278 9.309 1.00 53.58 ? 2195 HOH A O 1 HETATM 5230 O O . HOH L 7 . ? 41.649 -28.812 1.653 1.00 46.77 ? 2196 HOH A O 1 HETATM 5231 O O . HOH L 7 . ? 38.714 -29.555 0.862 1.00 42.11 ? 2197 HOH A O 1 HETATM 5232 O O . HOH L 7 . ? 35.867 -28.913 4.031 1.00 48.02 ? 2198 HOH A O 1 HETATM 5233 O O . HOH L 7 . ? 50.749 -25.709 5.295 1.00 30.83 ? 2199 HOH A O 1 HETATM 5234 O O . HOH L 7 . ? 53.667 -29.330 4.204 1.00 34.90 ? 2200 HOH A O 1 HETATM 5235 O O . HOH L 7 . ? 55.933 -28.904 1.318 1.00 36.59 ? 2201 HOH A O 1 HETATM 5236 O O . HOH L 7 . ? 45.135 -31.886 -3.710 1.00 40.99 ? 2202 HOH A O 1 HETATM 5237 O O . HOH L 7 . ? 41.355 -30.868 -2.178 1.00 46.50 ? 2203 HOH A O 1 HETATM 5238 O O . HOH L 7 . ? 39.227 -29.284 -1.800 1.00 36.40 ? 2204 HOH A O 1 HETATM 5239 O O . HOH L 7 . ? 49.010 -24.587 -7.442 1.00 48.17 ? 2205 HOH A O 1 HETATM 5240 O O . HOH L 7 . ? 38.930 -19.764 -1.921 1.00 33.17 ? 2206 HOH A O 1 HETATM 5241 O O . HOH L 7 . ? 50.808 -28.340 -5.554 1.00 37.10 ? 2207 HOH A O 1 HETATM 5242 O O . HOH L 7 . ? 55.117 -22.690 -2.586 1.00 48.78 ? 2208 HOH A O 1 HETATM 5243 O O . HOH L 7 . ? 55.094 -24.206 -0.135 1.00 41.10 ? 2209 HOH A O 1 HETATM 5244 O O . HOH L 7 . ? 54.219 -19.848 -6.756 1.00 37.50 ? 2210 HOH A O 1 HETATM 5245 O O . HOH L 7 . ? 53.948 -26.029 -7.733 1.00 40.25 ? 2211 HOH A O 1 HETATM 5246 O O . HOH L 7 . ? 48.404 -16.811 -4.982 1.00 39.28 ? 2212 HOH A O 1 HETATM 5247 O O . HOH L 7 . ? 50.527 -18.921 1.973 1.00 35.39 ? 2213 HOH A O 1 HETATM 5248 O O . HOH L 7 . ? 57.228 -22.353 1.712 1.00 51.39 ? 2214 HOH A O 1 HETATM 5249 O O . HOH L 7 . ? 56.827 -27.996 7.235 1.00 54.10 ? 2215 HOH A O 1 HETATM 5250 O O . HOH L 7 . ? 52.490 -27.239 6.973 1.00 31.99 ? 2216 HOH A O 1 HETATM 5251 O O . HOH L 7 . ? 57.103 -19.120 7.826 1.00 34.70 ? 2217 HOH A O 1 HETATM 5252 O O . HOH L 7 . ? 34.252 -15.321 3.999 1.00 32.86 ? 2218 HOH A O 1 HETATM 5253 O O . HOH L 7 . ? 32.480 -8.393 5.092 1.00 32.60 ? 2219 HOH A O 1 HETATM 5254 O O . HOH L 7 . ? 42.435 -6.434 4.611 1.00 32.92 ? 2220 HOH A O 1 HETATM 5255 O O . HOH L 7 . ? 42.374 -10.884 7.832 1.00 30.68 ? 2221 HOH A O 1 HETATM 5256 O O . HOH L 7 . ? 31.403 -9.387 7.291 1.00 45.35 ? 2222 HOH A O 1 HETATM 5257 O O . HOH L 7 . ? 31.977 -5.615 5.483 1.00 33.73 ? 2223 HOH A O 1 HETATM 5258 O O . HOH L 7 . ? 30.080 -11.916 13.272 1.00 33.37 ? 2224 HOH A O 1 HETATM 5259 O O . HOH L 7 . ? 26.619 -15.990 1.665 1.00 48.75 ? 2225 HOH A O 1 HETATM 5260 O O . HOH L 7 . ? 34.944 -35.887 7.571 1.00 44.03 ? 2226 HOH A O 1 HETATM 5261 O O . HOH L 7 . ? 30.959 -41.251 13.353 1.00 50.82 ? 2227 HOH A O 1 HETATM 5262 O O . HOH L 7 . ? 28.439 -28.861 12.074 1.00 37.18 ? 2228 HOH A O 1 HETATM 5263 O O . HOH L 7 . ? 26.163 -30.289 5.827 1.00 49.99 ? 2229 HOH A O 1 HETATM 5264 O O . HOH L 7 . ? 26.624 -27.606 4.068 1.00 51.88 ? 2230 HOH A O 1 HETATM 5265 O O . HOH L 7 . ? 23.794 -29.224 7.317 1.00 39.02 ? 2231 HOH A O 1 HETATM 5266 O O . HOH L 7 . ? 28.583 -26.180 11.221 1.00 32.00 ? 2232 HOH A O 1 HETATM 5267 O O . HOH L 7 . ? 27.579 -20.922 7.174 1.00 49.44 ? 2233 HOH A O 1 HETATM 5268 O O . HOH L 7 . ? 22.897 -26.844 6.363 1.00 35.10 ? 2234 HOH A O 1 HETATM 5269 O O . HOH L 7 . ? 20.495 -25.201 3.282 1.00 32.99 ? 2235 HOH A O 1 HETATM 5270 O O . HOH L 7 . ? 23.072 -23.215 1.472 1.00 40.65 ? 2236 HOH A O 1 HETATM 5271 O O . HOH L 7 . ? 23.675 -25.858 1.373 1.00 45.11 ? 2237 HOH A O 1 HETATM 5272 O O . HOH L 7 . ? 23.672 -27.149 3.739 1.00 44.12 ? 2238 HOH A O 1 HETATM 5273 O O . HOH L 7 . ? 25.492 -17.238 3.896 1.00 44.13 ? 2239 HOH A O 1 HETATM 5274 O O . HOH L 7 . ? 18.441 -29.237 3.764 1.00 45.49 ? 2240 HOH A O 1 HETATM 5275 O O . HOH L 7 . ? 11.719 -21.893 8.338 1.00 45.81 ? 2241 HOH A O 1 HETATM 5276 O O . HOH L 7 . ? 7.291 -12.027 2.869 1.00 48.31 ? 2242 HOH A O 1 HETATM 5277 O O . HOH L 7 . ? 10.618 -8.557 1.306 1.00 38.26 ? 2243 HOH A O 1 HETATM 5278 O O . HOH L 7 . ? 5.995 -6.334 9.002 1.00 47.55 ? 2244 HOH A O 1 HETATM 5279 O O . HOH L 7 . ? 12.203 -5.945 18.044 1.00 34.23 ? 2245 HOH A O 1 HETATM 5280 O O . HOH L 7 . ? 6.666 -5.043 15.014 1.00 40.96 ? 2246 HOH A O 1 HETATM 5281 O O . HOH L 7 . ? 7.875 -13.275 19.667 1.00 37.34 ? 2247 HOH A O 1 HETATM 5282 O O . HOH L 7 . ? 7.718 -8.325 23.945 1.00 45.88 ? 2248 HOH A O 1 HETATM 5283 O O . HOH L 7 . ? 5.043 -8.328 19.731 1.00 46.53 ? 2249 HOH A O 1 HETATM 5284 O O . HOH L 7 . ? 12.029 -9.809 30.860 1.00 37.73 ? 2250 HOH A O 1 HETATM 5285 O O . HOH L 7 . ? 12.163 -0.003 24.740 1.00 39.20 ? 2251 HOH A O 1 HETATM 5286 O O . HOH L 7 . ? 6.773 -4.317 22.605 1.00 44.42 ? 2252 HOH A O 1 HETATM 5287 O O . HOH L 7 . ? 7.677 -0.297 19.855 1.00 40.09 ? 2253 HOH A O 1 HETATM 5288 O O . HOH L 7 . ? 4.221 1.460 16.452 1.00 44.16 ? 2254 HOH A O 1 HETATM 5289 O O . HOH L 7 . ? 3.283 -3.173 8.885 1.00 45.12 ? 2255 HOH A O 1 HETATM 5290 O O . HOH L 7 . ? 4.867 5.949 9.464 1.00 36.00 ? 2256 HOH A O 1 HETATM 5291 O O . HOH L 7 . ? 6.731 9.822 11.193 1.00 48.79 ? 2257 HOH A O 1 HETATM 5292 O O . HOH L 7 . ? 3.104 6.124 4.944 1.00 55.27 ? 2258 HOH A O 1 HETATM 5293 O O . HOH L 7 . ? 12.179 -1.912 1.235 1.00 38.06 ? 2259 HOH A O 1 HETATM 5294 O O . HOH L 7 . ? 9.973 -5.944 1.458 1.00 55.93 ? 2260 HOH A O 1 HETATM 5295 O O . HOH L 7 . ? 18.480 -6.415 -1.912 1.00 36.28 ? 2261 HOH A O 1 HETATM 5296 O O . HOH L 7 . ? 16.279 -5.787 -5.269 1.00 52.05 ? 2262 HOH A O 1 HETATM 5297 O O . HOH L 7 . ? 12.914 0.442 -6.353 1.00 56.95 ? 2263 HOH A O 1 HETATM 5298 O O . HOH L 7 . ? 12.996 4.538 -1.372 1.00 61.73 ? 2264 HOH A O 1 HETATM 5299 O O . HOH L 7 . ? 27.039 1.060 -1.738 1.00 45.91 ? 2265 HOH A O 1 HETATM 5300 O O . HOH L 7 . ? 22.499 1.394 4.327 1.00 37.23 ? 2266 HOH A O 1 HETATM 5301 O O . HOH L 7 . ? 22.800 -3.697 2.892 1.00 38.93 ? 2267 HOH A O 1 HETATM 5302 O O . HOH L 7 . ? 28.647 -2.250 0.766 1.00 53.53 ? 2268 HOH A O 1 HETATM 5303 O O . HOH L 7 . ? 25.750 2.949 5.518 1.00 42.66 ? 2269 HOH A O 1 HETATM 5304 O O . HOH L 7 . ? 30.936 -2.764 2.499 1.00 33.82 ? 2270 HOH A O 1 HETATM 5305 O O . HOH L 7 . ? 26.269 -4.428 4.166 1.00 27.91 ? 2271 HOH A O 1 HETATM 5306 O O . HOH L 7 . ? 16.941 6.921 20.861 1.00 30.98 ? 2272 HOH A O 1 HETATM 5307 O O . HOH L 7 . ? 13.997 7.238 18.983 1.00 40.46 ? 2273 HOH A O 1 HETATM 5308 O O . HOH L 7 . ? 20.820 6.699 19.156 1.00 29.71 ? 2274 HOH A O 1 HETATM 5309 O O . HOH L 7 . ? 12.823 8.357 16.915 1.00 32.69 ? 2275 HOH A O 1 HETATM 5310 O O . HOH L 7 . ? 11.864 9.579 22.636 1.00 39.75 ? 2276 HOH A O 1 HETATM 5311 O O . HOH L 7 . ? 8.659 1.717 21.390 1.00 44.20 ? 2277 HOH A O 1 HETATM 5312 O O . HOH L 7 . ? 23.853 4.973 4.317 1.00 36.66 ? 2278 HOH A O 1 HETATM 5313 O O . HOH L 7 . ? 18.335 -12.970 -2.146 1.00 39.38 ? 2279 HOH A O 1 HETATM 5314 O O . HOH L 7 . ? 25.986 -22.042 11.990 1.00 36.56 ? 2280 HOH A O 1 HETATM 5315 O O . HOH L 7 . ? 25.874 -10.168 5.350 1.00 42.33 ? 2281 HOH A O 1 HETATM 5316 O O . HOH L 7 . ? 24.153 -6.266 3.674 1.00 40.07 ? 2282 HOH A O 1 HETATM 5317 O O . HOH L 7 . ? 25.686 -10.788 13.462 1.00 32.35 ? 2283 HOH A O 1 HETATM 5318 O O . HOH L 7 . ? 23.775 -4.648 17.502 1.00 31.08 ? 2284 HOH A O 1 HETATM 5319 O O . HOH L 7 . ? 14.712 -4.624 17.882 1.00 35.19 ? 2285 HOH A O 1 HETATM 5320 O O . HOH L 7 . ? 23.856 1.116 27.919 1.00 28.89 ? 2286 HOH A O 1 HETATM 5321 O O . HOH L 7 . ? 10.572 1.745 23.468 1.00 44.87 ? 2287 HOH A O 1 HETATM 5322 O O . HOH L 7 . ? 12.801 3.838 26.256 1.00 33.27 ? 2288 HOH A O 1 HETATM 5323 O O . HOH L 7 . ? 13.743 1.362 28.369 1.00 37.05 ? 2289 HOH A O 1 HETATM 5324 O O . HOH L 7 . ? 11.912 -0.194 27.262 1.00 40.10 ? 2290 HOH A O 1 HETATM 5325 O O . HOH L 7 . ? 12.078 -3.586 27.545 1.00 40.42 ? 2291 HOH A O 1 HETATM 5326 O O . HOH L 7 . ? 16.102 4.247 32.588 1.00 43.09 ? 2292 HOH A O 1 HETATM 5327 O O . HOH L 7 . ? 18.479 5.502 33.432 1.00 53.95 ? 2293 HOH A O 1 HETATM 5328 O O . HOH L 7 . ? 22.723 11.318 21.308 1.00 42.51 ? 2294 HOH A O 1 HETATM 5329 O O . HOH L 7 . ? 27.525 3.883 20.788 1.00 36.30 ? 2295 HOH A O 1 HETATM 5330 O O . HOH L 7 . ? 29.040 5.179 22.611 1.00 38.71 ? 2296 HOH A O 1 HETATM 5331 O O . HOH L 7 . ? 29.269 6.881 25.045 1.00 46.75 ? 2297 HOH A O 1 HETATM 5332 O O . HOH L 7 . ? 34.358 -2.154 26.936 1.00 35.83 ? 2298 HOH A O 1 HETATM 5333 O O . HOH L 7 . ? 28.965 1.656 17.806 1.00 33.64 ? 2299 HOH A O 1 HETATM 5334 O O . HOH L 7 . ? 29.611 -6.561 16.318 1.00 31.98 ? 2300 HOH A O 1 HETATM 5335 O O . HOH L 7 . ? 28.745 1.104 13.358 1.00 31.62 ? 2301 HOH A O 1 HETATM 5336 O O . HOH L 7 . ? 27.191 -12.925 16.090 1.00 32.61 ? 2302 HOH A O 1 HETATM 5337 O O . HOH L 7 . ? 29.296 -9.065 13.405 1.00 37.62 ? 2303 HOH A O 1 HETATM 5338 O O . HOH L 7 . ? 26.669 -15.200 14.609 1.00 42.55 ? 2304 HOH A O 1 HETATM 5339 O O . HOH L 7 . ? 26.762 -19.903 19.554 1.00 38.53 ? 2305 HOH A O 1 HETATM 5340 O O . HOH L 7 . ? 28.294 -19.245 14.390 1.00 35.46 ? 2306 HOH A O 1 HETATM 5341 O O . HOH L 7 . ? 23.353 -25.171 25.133 1.00 39.12 ? 2307 HOH A O 1 HETATM 5342 O O . HOH L 7 . ? 10.583 -26.202 12.328 1.00 41.94 ? 2308 HOH A O 1 HETATM 5343 O O . HOH L 7 . ? 20.178 -26.092 5.894 1.00 41.05 ? 2309 HOH A O 1 HETATM 5344 O O . HOH L 7 . ? 19.276 -28.948 6.184 1.00 41.79 ? 2310 HOH A O 1 HETATM 5345 O O . HOH L 7 . ? 22.409 -31.371 8.510 1.00 49.61 ? 2311 HOH A O 1 HETATM 5346 O O . HOH L 7 . ? 19.935 -33.321 5.187 1.00 57.44 ? 2312 HOH A O 1 HETATM 5347 O O . HOH L 7 . ? 15.629 -33.189 11.689 1.00 55.97 ? 2313 HOH A O 1 HETATM 5348 O O . HOH L 7 . ? 23.644 -33.870 7.787 1.00 46.50 ? 2314 HOH A O 1 HETATM 5349 O O . HOH L 7 . ? 23.706 -35.009 10.198 1.00 45.29 ? 2315 HOH A O 1 HETATM 5350 O O . HOH L 7 . ? 27.424 -35.686 12.424 1.00 48.57 ? 2316 HOH A O 1 HETATM 5351 O O . HOH L 7 . ? 27.067 -26.346 18.358 1.00 40.40 ? 2317 HOH A O 1 HETATM 5352 O O . HOH L 7 . ? 27.302 -39.742 14.198 1.00 47.06 ? 2318 HOH A O 1 HETATM 5353 O O . HOH L 7 . ? 31.971 -37.927 15.962 1.00 53.13 ? 2319 HOH A O 1 HETATM 5354 O O . HOH L 7 . ? 33.899 -32.219 19.880 1.00 44.62 ? 2320 HOH A O 1 HETATM 5355 O O . HOH L 7 . ? 31.864 -27.664 26.342 1.00 55.47 ? 2321 HOH A O 1 HETATM 5356 O O . HOH L 7 . ? 27.839 -22.614 17.554 1.00 48.77 ? 2322 HOH A O 1 HETATM 5357 O O . HOH L 7 . ? 30.724 -18.526 10.458 1.00 43.55 ? 2323 HOH A O 1 HETATM 5358 O O . HOH L 7 . ? 39.489 3.718 17.770 1.00 29.26 ? 2324 HOH A O 1 HETATM 5359 O O . HOH L 7 . ? 48.920 2.351 15.623 1.00 33.60 ? 2325 HOH A O 1 HETATM 5360 O O . HOH L 7 . ? 48.772 0.870 17.942 1.00 31.86 ? 2326 HOH A O 1 HETATM 5361 O O . HOH L 7 . ? 46.455 2.213 2.252 1.00 31.58 ? 2327 HOH A O 1 HETATM 5362 O O . HOH L 7 . ? 51.523 1.785 11.286 1.00 37.43 ? 2328 HOH A O 1 HETATM 5363 O O . HOH L 7 . ? 54.416 11.041 16.567 1.00 52.16 ? 2329 HOH A O 1 HETATM 5364 O O . HOH L 7 . ? 49.802 4.525 16.927 1.00 35.60 ? 2330 HOH A O 1 HETATM 5365 O O . HOH L 7 . ? 50.288 3.586 21.045 1.00 46.76 ? 2331 HOH A O 1 HETATM 5366 O O . HOH L 7 . ? 56.336 10.710 10.287 1.00 53.75 ? 2332 HOH A O 1 HETATM 5367 O O . HOH L 7 . ? 53.035 3.881 14.724 1.00 43.00 ? 2333 HOH A O 1 HETATM 5368 O O . HOH L 7 . ? 52.970 9.403 18.305 1.00 36.74 ? 2334 HOH A O 1 HETATM 5369 O O . HOH L 7 . ? 51.588 5.983 19.576 1.00 40.88 ? 2335 HOH A O 1 HETATM 5370 O O . HOH L 7 . ? 57.232 6.582 7.320 1.00 45.26 ? 2336 HOH A O 1 HETATM 5371 O O . HOH L 7 . ? 56.622 6.848 -1.995 1.00 49.93 ? 2337 HOH A O 1 HETATM 5372 O O . HOH L 7 . ? 55.666 1.967 6.484 1.00 51.94 ? 2338 HOH A O 1 HETATM 5373 O O . HOH L 7 . ? 61.023 5.423 4.803 1.00 56.04 ? 2339 HOH A O 1 HETATM 5374 O O . HOH L 7 . ? 52.388 0.158 9.441 1.00 29.59 ? 2340 HOH A O 1 HETATM 5375 O O . HOH L 7 . ? 49.832 -7.717 3.711 1.00 28.55 ? 2341 HOH A O 1 HETATM 5376 O O . HOH L 7 . ? 53.502 -5.706 3.266 1.00 36.30 ? 2342 HOH A O 1 HETATM 5377 O O . HOH L 7 . ? 55.218 -6.267 8.087 1.00 39.60 ? 2343 HOH A O 1 HETATM 5378 O O . HOH L 7 . ? 55.328 -10.422 9.085 1.00 35.12 ? 2344 HOH A O 1 HETATM 5379 O O . HOH L 7 . ? 54.827 -6.721 5.430 1.00 30.92 ? 2345 HOH A O 1 HETATM 5380 O O . HOH L 7 . ? 53.542 -11.551 12.663 1.00 43.03 ? 2346 HOH A O 1 HETATM 5381 O O . HOH L 7 . ? 55.038 -12.675 0.084 1.00 34.43 ? 2347 HOH A O 1 HETATM 5382 O O . HOH L 7 . ? 49.666 -13.294 -2.552 1.00 34.97 ? 2348 HOH A O 1 HETATM 5383 O O . HOH L 7 . ? 49.641 -14.487 -4.790 1.00 37.81 ? 2349 HOH A O 1 HETATM 5384 O O . HOH L 7 . ? 51.768 -8.911 -9.062 1.00 43.33 ? 2350 HOH A O 1 HETATM 5385 O O . HOH L 7 . ? 51.719 -0.503 -7.846 1.00 31.99 ? 2351 HOH A O 1 HETATM 5386 O O . HOH L 7 . ? 56.388 2.210 -3.907 1.00 36.90 ? 2352 HOH A O 1 HETATM 5387 O O . HOH L 7 . ? 41.085 -1.693 2.529 1.00 31.93 ? 2353 HOH A O 1 HETATM 5388 O O . HOH L 7 . ? 33.650 -2.853 3.360 1.00 30.32 ? 2354 HOH A O 1 HETATM 5389 O O . HOH L 7 . ? 33.540 7.293 13.664 1.00 35.87 ? 2355 HOH A O 1 HETATM 5390 O O . HOH L 7 . ? 32.323 11.413 9.666 1.00 36.52 ? 2356 HOH A O 1 HETATM 5391 O O . HOH L 7 . ? 28.296 5.375 13.785 1.00 42.79 ? 2357 HOH A O 1 HETATM 5392 O O . HOH L 7 . ? 30.424 7.049 13.448 1.00 49.72 ? 2358 HOH A O 1 HETATM 5393 O O . HOH L 7 . ? 33.278 5.945 17.846 1.00 35.55 ? 2359 HOH A O 1 HETATM 5394 O O . HOH L 7 . ? 30.712 6.642 18.554 1.00 39.82 ? 2360 HOH A O 1 HETATM 5395 O O . HOH L 7 . ? 35.255 -12.397 25.935 1.00 31.69 ? 2361 HOH A O 1 HETATM 5396 O O . HOH L 7 . ? 30.336 -13.640 31.027 1.00 35.86 ? 2362 HOH A O 1 HETATM 5397 O O . HOH L 7 . ? 32.334 -12.146 31.371 1.00 46.31 ? 2363 HOH A O 1 HETATM 5398 O O . HOH L 7 . ? 34.666 -9.489 33.577 1.00 44.83 ? 2364 HOH A O 1 HETATM 5399 O O . HOH L 7 . ? 32.197 -20.959 33.339 1.00 42.36 ? 2365 HOH A O 1 HETATM 5400 O O . HOH L 7 . ? 27.237 -14.258 34.324 1.00 43.60 ? 2366 HOH A O 1 HETATM 5401 O O . HOH L 7 . ? 19.805 -10.468 35.332 1.00 45.14 ? 2367 HOH A O 1 HETATM 5402 O O . HOH L 7 . ? 32.612 -24.614 28.529 1.00 40.77 ? 2368 HOH A O 1 HETATM 5403 O O . HOH L 7 . ? 22.911 -29.124 22.893 1.00 46.58 ? 2369 HOH A O 1 HETATM 5404 O O . HOH L 7 . ? 30.960 -24.981 26.278 1.00 41.10 ? 2370 HOH A O 1 HETATM 5405 O O . HOH L 7 . ? 31.806 -24.006 23.912 1.00 36.17 ? 2371 HOH A O 1 HETATM 5406 O O . HOH L 7 . ? 16.192 -19.813 25.813 1.00 50.09 ? 2372 HOH A O 1 HETATM 5407 O O . HOH L 7 . ? 13.825 -17.460 30.936 1.00 47.90 ? 2373 HOH A O 1 HETATM 5408 O O . HOH L 7 . ? 17.683 -11.693 34.207 1.00 38.37 ? 2374 HOH A O 1 HETATM 5409 O O . HOH L 7 . ? 19.271 -0.443 34.714 1.00 43.82 ? 2375 HOH A O 1 HETATM 5410 O O . HOH L 7 . ? 20.628 -8.100 34.771 1.00 44.70 ? 2376 HOH A O 1 HETATM 5411 O O . HOH L 7 . ? 25.321 3.772 30.864 1.00 29.20 ? 2377 HOH A O 1 HETATM 5412 O O . HOH L 7 . ? 21.606 5.554 34.660 1.00 41.87 ? 2378 HOH A O 1 HETATM 5413 O O . HOH L 7 . ? 25.075 -0.248 37.160 1.00 43.79 ? 2379 HOH A O 1 HETATM 5414 O O . HOH L 7 . ? 23.607 -6.619 38.243 1.00 55.33 ? 2380 HOH A O 1 HETATM 5415 O O . HOH L 7 . ? 34.405 -7.349 37.355 1.00 45.04 ? 2381 HOH A O 1 HETATM 5416 O O . HOH L 7 . ? 36.605 -1.448 33.479 1.00 35.30 ? 2382 HOH A O 1 HETATM 5417 O O . HOH L 7 . ? 34.806 -12.803 30.117 1.00 37.44 ? 2383 HOH A O 1 HETATM 5418 O O . HOH L 7 . ? 41.101 -11.010 29.531 1.00 32.62 ? 2384 HOH A O 1 HETATM 5419 O O . HOH L 7 . ? 38.513 -18.769 29.541 1.00 38.78 ? 2385 HOH A O 1 HETATM 5420 O O . HOH L 7 . ? 40.283 -21.147 24.079 1.00 32.83 ? 2386 HOH A O 1 HETATM 5421 O O . HOH L 7 . ? 38.841 -21.157 28.452 1.00 52.23 ? 2387 HOH A O 1 HETATM 5422 O O . HOH L 7 . ? 35.165 -24.133 27.648 1.00 41.39 ? 2388 HOH A O 1 HETATM 5423 O O . HOH L 7 . ? 40.058 -27.854 27.880 1.00 49.09 ? 2389 HOH A O 1 HETATM 5424 O O . HOH L 7 . ? 37.771 -30.884 21.817 1.00 46.10 ? 2390 HOH A O 1 HETATM 5425 O O . HOH L 7 . ? 46.029 -28.378 23.908 1.00 49.40 ? 2391 HOH A O 1 HETATM 5426 O O . HOH L 7 . ? 45.411 -30.249 22.152 1.00 36.11 ? 2392 HOH A O 1 HETATM 5427 O O . HOH L 7 . ? 39.730 -32.497 21.088 1.00 57.99 ? 2393 HOH A O 1 HETATM 5428 O O . HOH L 7 . ? 46.515 -22.222 20.654 1.00 40.43 ? 2394 HOH A O 1 HETATM 5429 O O . HOH L 7 . ? 48.031 -30.726 21.294 1.00 38.59 ? 2395 HOH A O 1 HETATM 5430 O O . HOH L 7 . ? 48.500 -34.309 18.031 1.00 40.89 ? 2396 HOH A O 1 HETATM 5431 O O . HOH L 7 . ? 52.080 -27.730 13.916 1.00 41.63 ? 2397 HOH A O 1 HETATM 5432 O O . HOH L 7 . ? 54.289 -32.634 14.145 1.00 41.13 ? 2398 HOH A O 1 HETATM 5433 O O . HOH L 7 . ? 52.813 -35.635 10.717 1.00 45.61 ? 2399 HOH A O 1 HETATM 5434 O O . HOH L 7 . ? 51.133 -29.680 7.078 1.00 36.60 ? 2400 HOH A O 1 HETATM 5435 O O . HOH L 7 . ? 54.133 -30.745 7.029 1.00 34.21 ? 2401 HOH A O 1 HETATM 5436 O O . HOH L 7 . ? 55.804 -28.160 9.694 1.00 44.03 ? 2402 HOH A O 1 HETATM 5437 O O . HOH L 7 . ? 54.065 -29.830 13.886 1.00 50.87 ? 2403 HOH A O 1 HETATM 5438 O O . HOH L 7 . ? 55.407 -24.352 12.766 1.00 38.10 ? 2404 HOH A O 1 HETATM 5439 O O . HOH L 7 . ? 54.862 -15.337 11.835 1.00 51.48 ? 2405 HOH A O 1 HETATM 5440 O O . HOH L 7 . ? 55.331 -12.850 11.093 1.00 46.94 ? 2406 HOH A O 1 HETATM 5441 O O . HOH L 7 . ? 57.240 -13.977 2.334 1.00 41.47 ? 2407 HOH A O 1 HETATM 5442 O O . HOH L 7 . ? 60.609 -13.117 6.725 1.00 41.43 ? 2408 HOH A O 1 HETATM 5443 O O . HOH L 7 . ? 55.980 -6.234 0.941 1.00 40.32 ? 2409 HOH A O 1 HETATM 5444 O O . HOH L 7 . ? 59.116 -6.599 3.150 1.00 56.59 ? 2410 HOH A O 1 HETATM 5445 O O . HOH L 7 . ? 51.824 -7.216 1.842 1.00 26.40 ? 2411 HOH A O 1 HETATM 5446 O O . HOH L 7 . ? 57.448 -8.841 -4.904 1.00 33.98 ? 2412 HOH A O 1 HETATM 5447 O O . HOH L 7 . ? 58.723 -5.321 0.285 1.00 60.92 ? 2413 HOH A O 1 HETATM 5448 O O . HOH L 7 . ? 60.186 -3.377 -1.266 1.00 53.08 ? 2414 HOH A O 1 HETATM 5449 O O . HOH L 7 . ? 37.126 27.533 28.008 1.00 44.04 ? 2415 HOH A O 1 HETATM 5450 O O . HOH M 7 . ? 28.493 4.243 18.332 1.00 49.05 ? 2001 HOH P O 1 HETATM 5451 O O . HOH M 7 . ? 29.388 -7.323 7.763 1.00 33.79 ? 2002 HOH P O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 ALA 1 17 17 ALA ALA A . n A 1 2 LEU 2 18 18 LEU LEU A . n A 1 3 VAL 3 19 19 VAL VAL A . n A 1 4 LYS 4 20 20 LYS LYS A . n A 1 5 GLU 5 21 21 GLU GLU A . n A 1 6 GLU 6 22 22 GLU GLU A . n A 1 7 ILE 7 23 23 ILE ILE A . n A 1 8 GLN 8 24 24 GLN GLN A . n A 1 9 ALA 9 25 25 ALA ALA A . n A 1 10 LYS 10 26 26 LYS LYS A . n A 1 11 GLU 11 27 27 GLU GLU A . n A 1 12 TYR 12 28 28 TYR TYR A . n A 1 13 LEU 13 29 29 LEU LEU A . n A 1 14 GLU 14 30 30 GLU GLU A . n A 1 15 ASN 15 31 31 ASN ASN A . n A 1 16 LEU 16 32 32 LEU LEU A . n A 1 17 ASN 17 33 33 ASN ASN A . n A 1 18 LYS 18 34 34 LYS LYS A . n A 1 19 GLU 19 35 35 GLU GLU A . n A 1 20 LEU 20 36 36 LEU LEU A . n A 1 21 ALA 21 37 37 ALA ALA A . n A 1 22 LYS 22 38 38 LYS LYS A . n A 1 23 ARG 23 39 39 ARG ARG A . n A 1 24 THR 24 40 40 THR THR A . n A 1 25 ASN 25 41 41 ASN ASN A . n A 1 26 VAL 26 42 42 VAL VAL A . n A 1 27 GLU 27 43 43 GLU GLU A . n A 1 28 THR 28 44 44 THR THR A . n A 1 29 GLU 29 45 45 GLU GLU A . n A 1 30 ALA 30 46 46 ALA ALA A . n A 1 31 ALA 31 47 47 ALA ALA A . n A 1 32 TRP 32 48 48 TRP TRP A . n A 1 33 ALA 33 49 49 ALA ALA A . n A 1 34 TYR 34 50 50 TYR TYR A . n A 1 35 GLY 35 51 51 GLY GLY A . n A 1 36 SER 36 52 52 SER SER A . n A 1 37 ASN 37 53 53 ASN ASN A . n A 1 38 ILE 38 54 54 ILE ILE A . n A 1 39 THR 39 55 55 THR THR A . n A 1 40 ASP 40 56 56 ASP ASP A . n A 1 41 GLU 41 57 57 GLU GLU A . n A 1 42 ASN 42 58 58 ASN ASN A . n A 1 43 GLU 43 59 59 GLU GLU A . n A 1 44 LYS 44 60 60 LYS LYS A . n A 1 45 LYS 45 61 61 LYS LYS A . n A 1 46 LYS 46 62 62 LYS LYS A . n A 1 47 ASN 47 63 63 ASN ASN A . n A 1 48 GLU 48 64 64 GLU GLU A . n A 1 49 ILE 49 65 65 ILE ILE A . n A 1 50 SER 50 66 66 SER SER A . n A 1 51 ALA 51 67 67 ALA ALA A . n A 1 52 GLU 52 68 68 GLU GLU A . n A 1 53 LEU 53 69 69 LEU LEU A . n A 1 54 ALA 54 70 70 ALA ALA A . n A 1 55 LYS 55 71 71 LYS LYS A . n A 1 56 PHE 56 72 72 PHE PHE A . n A 1 57 MET 57 73 73 MET MET A . n A 1 58 LYS 58 74 74 LYS LYS A . n A 1 59 GLU 59 75 75 GLU GLU A . n A 1 60 VAL 60 76 76 VAL VAL A . n A 1 61 ALA 61 77 77 ALA ALA A . n A 1 62 SER 62 78 78 SER SER A . n A 1 63 ASP 63 79 79 ASP ASP A . n A 1 64 THR 64 80 80 THR THR A . n A 1 65 THR 65 81 81 THR THR A . n A 1 66 LYS 66 82 82 LYS LYS A . n A 1 67 PHE 67 83 83 PHE PHE A . n A 1 68 GLN 68 84 84 GLN GLN A . n A 1 69 TRP 69 85 85 TRP TRP A . n A 1 70 ARG 70 86 86 ARG ARG A . n A 1 71 SER 71 87 87 SER SER A . n A 1 72 TYR 72 88 88 TYR TYR A . n A 1 73 GLN 73 89 89 GLN GLN A . n A 1 74 SER 74 90 90 SER SER A . n A 1 75 GLU 75 91 91 GLU GLU A . n A 1 76 ASP 76 92 92 ASP ASP A . n A 1 77 LEU 77 93 93 LEU LEU A . n A 1 78 LYS 78 94 94 LYS LYS A . n A 1 79 ARG 79 95 95 ARG ARG A . n A 1 80 GLN 80 96 96 GLN GLN A . n A 1 81 PHE 81 97 97 PHE PHE A . n A 1 82 LYS 82 98 98 LYS LYS A . n A 1 83 ALA 83 99 99 ALA ALA A . n A 1 84 LEU 84 100 100 LEU LEU A . n A 1 85 THR 85 101 101 THR THR A . n A 1 86 LYS 86 102 102 LYS LYS A . n A 1 87 LEU 87 103 103 LEU LEU A . n A 1 88 GLY 88 104 104 GLY GLY A . n A 1 89 TYR 89 105 105 TYR TYR A . n A 1 90 ALA 90 106 106 ALA ALA A . n A 1 91 ALA 91 107 107 ALA ALA A . n A 1 92 LEU 92 108 108 LEU LEU A . n A 1 93 PRO 93 109 109 PRO PRO A . n A 1 94 GLU 94 110 110 GLU GLU A . n A 1 95 ASP 95 111 111 ASP ASP A . n A 1 96 ASP 96 112 112 ASP ASP A . n A 1 97 TYR 97 113 113 TYR TYR A . n A 1 98 ALA 98 114 114 ALA ALA A . n A 1 99 GLU 99 115 115 GLU GLU A . n A 1 100 LEU 100 116 116 LEU LEU A . n A 1 101 LEU 101 117 117 LEU LEU A . n A 1 102 ASP 102 118 118 ASP ASP A . n A 1 103 THR 103 119 119 THR THR A . n A 1 104 LEU 104 120 120 LEU LEU A . n A 1 105 SER 105 121 121 SER SER A . n A 1 106 ALA 106 122 122 ALA ALA A . n A 1 107 MET 107 123 123 MET MET A . n A 1 108 GLU 108 124 124 GLU GLU A . n A 1 109 SER 109 125 125 SER SER A . n A 1 110 ASN 110 126 126 ASN ASN A . n A 1 111 PHE 111 127 127 PHE PHE A . n A 1 112 ALA 112 128 128 ALA ALA A . n A 1 113 LYS 113 129 129 LYS LYS A . n A 1 114 VAL 114 130 130 VAL VAL A . n A 1 115 LYS 115 131 131 LYS LYS A . n A 1 116 VAL 116 132 132 VAL VAL A . n A 1 117 CYS 117 133 133 CYS CYS A . n A 1 118 ASP 118 134 134 ASP ASP A . n A 1 119 TYR 119 135 135 TYR TYR A . n A 1 120 LYS 120 136 136 LYS LYS A . n A 1 121 ASP 121 137 137 ASP ASP A . n A 1 122 SER 122 138 138 SER SER A . n A 1 123 THR 123 139 139 THR THR A . n A 1 124 LYS 124 140 140 LYS LYS A . n A 1 125 CYS 125 141 141 CYS CYS A . n A 1 126 ASP 126 142 142 ASP ASP A . n A 1 127 LEU 127 143 143 LEU LEU A . n A 1 128 ALA 128 144 144 ALA ALA A . n A 1 129 LEU 129 145 145 LEU LEU A . n A 1 130 ASP 130 146 146 ASP ASP A . n A 1 131 PRO 131 147 147 PRO PRO A . n A 1 132 GLU 132 148 148 GLU GLU A . n A 1 133 ILE 133 149 149 ILE ILE A . n A 1 134 GLU 134 150 150 GLU GLU A . n A 1 135 GLU 135 151 151 GLU GLU A . n A 1 136 VAL 136 152 152 VAL VAL A . n A 1 137 ILE 137 153 153 ILE ILE A . n A 1 138 SER 138 154 154 SER SER A . n A 1 139 LYS 139 155 155 LYS LYS A . n A 1 140 SER 140 156 156 SER SER A . n A 1 141 ARG 141 157 157 ARG ARG A . n A 1 142 ASP 142 158 158 ASP ASP A . n A 1 143 HIS 143 159 159 HIS HIS A . n A 1 144 GLU 144 160 160 GLU GLU A . n A 1 145 GLU 145 161 161 GLU GLU A . n A 1 146 LEU 146 162 162 LEU LEU A . n A 1 147 ALA 147 163 163 ALA ALA A . n A 1 148 TYR 148 164 164 TYR TYR A . n A 1 149 TYR 149 165 165 TYR TYR A . n A 1 150 TRP 150 166 166 TRP TRP A . n A 1 151 ARG 151 167 167 ARG ARG A . n A 1 152 GLU 152 168 168 GLU GLU A . n A 1 153 PHE 153 169 169 PHE PHE A . n A 1 154 TYR 154 170 170 TYR TYR A . n A 1 155 ASP 155 171 171 ASP ASP A . n A 1 156 LYS 156 172 172 LYS LYS A . n A 1 157 ALA 157 173 173 ALA ALA A . n A 1 158 GLY 158 174 174 GLY GLY A . n A 1 159 THR 159 175 175 THR THR A . n A 1 160 ALA 160 176 176 ALA ALA A . n A 1 161 VAL 161 177 177 VAL VAL A . n A 1 162 ARG 162 178 178 ARG ARG A . n A 1 163 SER 163 179 179 SER SER A . n A 1 164 GLN 164 180 180 GLN GLN A . n A 1 165 PHE 165 181 181 PHE PHE A . n A 1 166 GLU 166 182 182 GLU GLU A . n A 1 167 ARG 167 183 183 ARG ARG A . n A 1 168 TYR 168 184 184 TYR TYR A . n A 1 169 VAL 169 185 185 VAL VAL A . n A 1 170 GLU 170 186 186 GLU GLU A . n A 1 171 LEU 171 187 187 LEU LEU A . n A 1 172 ASN 172 188 188 ASN ASN A . n A 1 173 THR 173 189 189 THR THR A . n A 1 174 LYS 174 190 190 LYS LYS A . n A 1 175 ALA 175 191 191 ALA ALA A . n A 1 176 ALA 176 192 192 ALA ALA A . n A 1 177 LYS 177 193 193 LYS LYS A . n A 1 178 LEU 178 194 194 LEU LEU A . n A 1 179 ASN 179 195 195 ASN ASN A . n A 1 180 ASN 180 196 196 ASN ASN A . n A 1 181 PHE 181 197 197 PHE PHE A . n A 1 182 THR 182 198 198 THR THR A . n A 1 183 SER 183 199 199 SER SER A . n A 1 184 GLY 184 200 200 GLY GLY A . n A 1 185 ALA 185 201 201 ALA ALA A . n A 1 186 GLU 186 202 202 GLU GLU A . n A 1 187 ALA 187 203 203 ALA ALA A . n A 1 188 TRP 188 204 204 TRP TRP A . n A 1 189 LEU 189 205 205 LEU LEU A . n A 1 190 ASP 190 206 206 ASP ASP A . n A 1 191 GLU 191 207 207 GLU GLU A . n A 1 192 TYR 192 208 208 TYR TYR A . n A 1 193 GLU 193 209 209 GLU GLU A . n A 1 194 ASP 194 210 210 ASP ASP A . n A 1 195 ASP 195 211 211 ASP ASP A . n A 1 196 THR 196 212 212 THR THR A . n A 1 197 PHE 197 213 213 PHE PHE A . n A 1 198 GLU 198 214 214 GLU GLU A . n A 1 199 GLN 199 215 215 GLN GLN A . n A 1 200 GLN 200 216 216 GLN GLN A . n A 1 201 LEU 201 217 217 LEU LEU A . n A 1 202 GLU 202 218 218 GLU GLU A . n A 1 203 ASP 203 219 219 ASP ASP A . n A 1 204 ILE 204 220 220 ILE ILE A . n A 1 205 PHE 205 221 221 PHE PHE A . n A 1 206 ALA 206 222 222 ALA ALA A . n A 1 207 ASP 207 223 223 ASP ASP A . n A 1 208 ILE 208 224 224 ILE ILE A . n A 1 209 ARG 209 225 225 ARG ARG A . n A 1 210 PRO 210 226 226 PRO PRO A . n A 1 211 LEU 211 227 227 LEU LEU A . n A 1 212 TYR 212 228 228 TYR TYR A . n A 1 213 GLN 213 229 229 GLN GLN A . n A 1 214 GLN 214 230 230 GLN GLN A . n A 1 215 ILE 215 231 231 ILE ILE A . n A 1 216 HIS 216 232 232 HIS HIS A . n A 1 217 GLY 217 233 233 GLY GLY A . n A 1 218 TYR 218 234 234 TYR TYR A . n A 1 219 VAL 219 235 235 VAL VAL A . n A 1 220 ARG 220 236 236 ARG ARG A . n A 1 221 PHE 221 237 237 PHE PHE A . n A 1 222 ARG 222 238 238 ARG ARG A . n A 1 223 LEU 223 239 239 LEU LEU A . n A 1 224 ARG 224 240 240 ARG ARG A . n A 1 225 LYS 225 241 241 LYS LYS A . n A 1 226 HIS 226 242 242 HIS HIS A . n A 1 227 TYR 227 243 243 TYR TYR A . n A 1 228 GLY 228 244 244 GLY GLY A . n A 1 229 ASP 229 245 245 ASP ASP A . n A 1 230 ALA 230 246 246 ALA ALA A . n A 1 231 VAL 231 247 247 VAL VAL A . n A 1 232 VAL 232 248 248 VAL VAL A . n A 1 233 SER 233 249 249 SER SER A . n A 1 234 GLU 234 250 250 GLU GLU A . n A 1 235 THR 235 251 251 THR THR A . n A 1 236 GLY 236 252 252 GLY GLY A . n A 1 237 PRO 237 253 253 PRO PRO A . n A 1 238 ILE 238 254 254 ILE ILE A . n A 1 239 PRO 239 255 255 PRO PRO A . n A 1 240 MET 240 256 256 MET MET A . n A 1 241 HIS 241 257 257 HIS HIS A . n A 1 242 LEU 242 258 258 LEU LEU A . n A 1 243 LEU 243 259 259 LEU LEU A . n A 1 244 GLY 244 260 260 GLY GLY A . n A 1 245 ASN 245 261 261 ASN ASN A . n A 1 246 MET 246 262 262 MET MET A . n A 1 247 TRP 247 263 263 TRP TRP A . n A 1 248 ALA 248 264 264 ALA ALA A . n A 1 249 GLN 249 265 265 GLN GLN A . n A 1 250 GLN 250 266 266 GLN GLN A . n A 1 251 TRP 251 267 267 TRP TRP A . n A 1 252 SER 252 268 268 SER SER A . n A 1 253 GLU 253 269 269 GLU GLU A . n A 1 254 ILE 254 270 270 ILE ILE A . n A 1 255 ALA 255 271 271 ALA ALA A . n A 1 256 ASP 256 272 272 ASP ASP A . n A 1 257 ILE 257 273 273 ILE ILE A . n A 1 258 VAL 258 274 274 VAL VAL A . n A 1 259 SER 259 275 275 SER SER A . n A 1 260 PRO 260 276 276 PRO PRO A . n A 1 261 PHE 261 277 277 PHE PHE A . n A 1 262 PRO 262 278 278 PRO PRO A . n A 1 263 GLU 263 279 279 GLU GLU A . n A 1 264 LYS 264 280 280 LYS LYS A . n A 1 265 PRO 265 281 281 PRO PRO A . n A 1 266 LEU 266 282 282 LEU LEU A . n A 1 267 VAL 267 283 283 VAL VAL A . n A 1 268 ASP 268 284 284 ASP ASP A . n A 1 269 VAL 269 285 285 VAL VAL A . n A 1 270 SER 270 286 286 SER SER A . n A 1 271 ALA 271 287 287 ALA ALA A . n A 1 272 GLU 272 288 288 GLU GLU A . n A 1 273 MET 273 289 289 MET MET A . n A 1 274 GLU 274 290 290 GLU GLU A . n A 1 275 LYS 275 291 291 LYS LYS A . n A 1 276 GLN 276 292 292 GLN GLN A . n A 1 277 GLY 277 293 293 GLY GLY A . n A 1 278 TYR 278 294 294 TYR TYR A . n A 1 279 THR 279 295 295 THR THR A . n A 1 280 PRO 280 296 296 PRO PRO A . n A 1 281 LEU 281 297 297 LEU LEU A . n A 1 282 LYS 282 298 298 LYS LYS A . n A 1 283 MET 283 299 299 MET MET A . n A 1 284 PHE 284 300 300 PHE PHE A . n A 1 285 GLN 285 301 301 GLN GLN A . n A 1 286 MET 286 302 302 MET MET A . n A 1 287 GLY 287 303 303 GLY GLY A . n A 1 288 ASP 288 304 304 ASP ASP A . n A 1 289 ASP 289 305 305 ASP ASP A . n A 1 290 PHE 290 306 306 PHE PHE A . n A 1 291 PHE 291 307 307 PHE PHE A . n A 1 292 THR 292 308 308 THR THR A . n A 1 293 SER 293 309 309 SER SER A . n A 1 294 MET 294 310 310 MET MET A . n A 1 295 ASN 295 311 311 ASN ASN A . n A 1 296 LEU 296 312 312 LEU LEU A . n A 1 297 THR 297 313 313 THR THR A . n A 1 298 LYS 298 314 314 LYS LYS A . n A 1 299 LEU 299 315 315 LEU LEU A . n A 1 300 PRO 300 316 316 PRO PRO A . n A 1 301 GLN 301 317 317 GLN GLN A . n A 1 302 ASP 302 318 318 ASP ASP A . n A 1 303 PHE 303 319 319 PHE PHE A . n A 1 304 TRP 304 320 320 TRP TRP A . n A 1 305 ASP 305 321 321 ASP ASP A . n A 1 306 LYS 306 322 322 LYS LYS A . n A 1 307 SER 307 323 323 SER SER A . n A 1 308 ILE 308 324 324 ILE ILE A . n A 1 309 ILE 309 325 325 ILE ILE A . n A 1 310 GLU 310 326 326 GLU GLU A . n A 1 311 LYS 311 327 327 LYS LYS A . n A 1 312 PRO 312 328 328 PRO PRO A . n A 1 313 THR 313 329 329 THR THR A . n A 1 314 ASP 314 330 330 ASP ASP A . n A 1 315 GLY 315 331 331 GLY GLY A . n A 1 316 ARG 316 332 332 ARG ARG A . n A 1 317 ASP 317 333 333 ASP ASP A . n A 1 318 LEU 318 334 334 LEU LEU A . n A 1 319 VAL 319 335 335 VAL VAL A . n A 1 320 CYS 320 336 336 CYS CYS A . n A 1 321 HIS 321 337 337 HIS HIS A . n A 1 322 ALA 322 338 338 ALA ALA A . n A 1 323 SER 323 339 339 SER SER A . n A 1 324 ALA 324 340 340 ALA ALA A . n A 1 325 TRP 325 341 341 TRP TRP A . n A 1 326 ASP 326 342 342 ASP ASP A . n A 1 327 PHE 327 343 343 PHE PHE A . n A 1 328 TYR 328 344 344 TYR TYR A . n A 1 329 LEU 329 345 345 LEU LEU A . n A 1 330 THR 330 346 346 THR THR A . n A 1 331 ASP 331 347 347 ASP ASP A . n A 1 332 ASP 332 348 348 ASP ASP A . n A 1 333 VAL 333 349 349 VAL VAL A . n A 1 334 ARG 334 350 350 ARG ARG A . n A 1 335 ILE 335 351 351 ILE ILE A . n A 1 336 LYS 336 352 352 LYS LYS A . n A 1 337 GLN 337 353 353 GLN GLN A . n A 1 338 CYS 338 354 354 CYS CYS A . n A 1 339 THR 339 355 355 THR THR A . n A 1 340 ARG 340 356 356 ARG ARG A . n A 1 341 VAL 341 357 357 VAL VAL A . n A 1 342 THR 342 358 358 THR THR A . n A 1 343 GLN 343 359 359 GLN GLN A . n A 1 344 ASP 344 360 360 ASP ASP A . n A 1 345 GLN 345 361 361 GLN GLN A . n A 1 346 LEU 346 362 362 LEU LEU A . n A 1 347 PHE 347 363 363 PHE PHE A . n A 1 348 THR 348 364 364 THR THR A . n A 1 349 VAL 349 365 365 VAL VAL A . n A 1 350 HIS 350 366 366 HIS HIS A . n A 1 351 HIS 351 367 367 HIS HIS A . n A 1 352 GLU 352 368 368 GLU GLU A . n A 1 353 LEU 353 369 369 LEU LEU A . n A 1 354 GLY 354 370 370 GLY GLY A . n A 1 355 HIS 355 371 371 HIS HIS A . n A 1 356 ILE 356 372 372 ILE ILE A . n A 1 357 GLN 357 373 373 GLN GLN A . n A 1 358 TYR 358 374 374 TYR TYR A . n A 1 359 PHE 359 375 375 PHE PHE A . n A 1 360 LEU 360 376 376 LEU LEU A . n A 1 361 GLN 361 377 377 GLN GLN A . n A 1 362 TYR 362 378 378 TYR TYR A . n A 1 363 GLN 363 379 379 GLN GLN A . n A 1 364 HIS 364 380 380 HIS HIS A . n A 1 365 GLN 365 381 381 GLN GLN A . n A 1 366 PRO 366 382 382 PRO PRO A . n A 1 367 PHE 367 383 383 PHE PHE A . n A 1 368 VAL 368 384 384 VAL VAL A . n A 1 369 TYR 369 385 385 TYR TYR A . n A 1 370 ARG 370 386 386 ARG ARG A . n A 1 371 THR 371 387 387 THR THR A . n A 1 372 GLY 372 388 388 GLY GLY A . n A 1 373 ALA 373 389 389 ALA ALA A . n A 1 374 ASN 374 390 390 ASN ASN A . n A 1 375 PRO 375 391 391 PRO PRO A . n A 1 376 GLY 376 392 392 GLY GLY A . n A 1 377 PHE 377 393 393 PHE PHE A . n A 1 378 HIS 378 394 394 HIS HIS A . n A 1 379 GLU 379 395 395 GLU GLU A . n A 1 380 ALA 380 396 396 ALA ALA A . n A 1 381 VAL 381 397 397 VAL VAL A . n A 1 382 GLY 382 398 398 GLY GLY A . n A 1 383 ASP 383 399 399 ASP ASP A . n A 1 384 VAL 384 400 400 VAL VAL A . n A 1 385 LEU 385 401 401 LEU LEU A . n A 1 386 SER 386 402 402 SER SER A . n A 1 387 LEU 387 403 403 LEU LEU A . n A 1 388 SER 388 404 404 SER SER A . n A 1 389 VAL 389 405 405 VAL VAL A . n A 1 390 SER 390 406 406 SER SER A . n A 1 391 THR 391 407 407 THR THR A . n A 1 392 PRO 392 408 408 PRO PRO A . n A 1 393 LYS 393 409 409 LYS LYS A . n A 1 394 HIS 394 410 410 HIS HIS A . n A 1 395 LEU 395 411 411 LEU LEU A . n A 1 396 GLU 396 412 412 GLU GLU A . n A 1 397 LYS 397 413 413 LYS LYS A . n A 1 398 ILE 398 414 414 ILE ILE A . n A 1 399 GLY 399 415 415 GLY GLY A . n A 1 400 LEU 400 416 416 LEU LEU A . n A 1 401 LEU 401 417 417 LEU LEU A . n A 1 402 LYS 402 418 418 LYS LYS A . n A 1 403 ASP 403 419 419 ASP ASP A . n A 1 404 TYR 404 420 420 TYR TYR A . n A 1 405 VAL 405 421 421 VAL VAL A . n A 1 406 ARG 406 422 422 ARG ARG A . n A 1 407 ASP 407 423 423 ASP ASP A . n A 1 408 ASP 408 424 424 ASP ASP A . n A 1 409 GLU 409 425 425 GLU GLU A . n A 1 410 ALA 410 426 426 ALA ALA A . n A 1 411 ARG 411 427 427 ARG ARG A . n A 1 412 ILE 412 428 428 ILE ILE A . n A 1 413 ASN 413 429 429 ASN ASN A . n A 1 414 GLN 414 430 430 GLN GLN A . n A 1 415 LEU 415 431 431 LEU LEU A . n A 1 416 PHE 416 432 432 PHE PHE A . n A 1 417 LEU 417 433 433 LEU LEU A . n A 1 418 THR 418 434 434 THR THR A . n A 1 419 ALA 419 435 435 ALA ALA A . n A 1 420 LEU 420 436 436 LEU LEU A . n A 1 421 ASP 421 437 437 ASP ASP A . n A 1 422 LYS 422 438 438 LYS LYS A . n A 1 423 ILE 423 439 439 ILE ILE A . n A 1 424 VAL 424 440 440 VAL VAL A . n A 1 425 PHE 425 441 441 PHE PHE A . n A 1 426 LEU 426 442 442 LEU LEU A . n A 1 427 PRO 427 443 443 PRO PRO A . n A 1 428 PHE 428 444 444 PHE PHE A . n A 1 429 ALA 429 445 445 ALA ALA A . n A 1 430 PHE 430 446 446 PHE PHE A . n A 1 431 THR 431 447 447 THR THR A . n A 1 432 MET 432 448 448 MET MET A . n A 1 433 ASP 433 449 449 ASP ASP A . n A 1 434 LYS 434 450 450 LYS LYS A . n A 1 435 TYR 435 451 451 TYR TYR A . n A 1 436 ARG 436 452 452 ARG ARG A . n A 1 437 TRP 437 453 453 TRP TRP A . n A 1 438 SER 438 454 454 SER SER A . n A 1 439 LEU 439 455 455 LEU LEU A . n A 1 440 PHE 440 456 456 PHE PHE A . n A 1 441 ARG 441 457 457 ARG ARG A . n A 1 442 GLY 442 458 458 GLY GLY A . n A 1 443 GLU 443 459 459 GLU GLU A . n A 1 444 VAL 444 460 460 VAL VAL A . n A 1 445 ASP 445 461 461 ASP ASP A . n A 1 446 LYS 446 462 462 LYS LYS A . n A 1 447 ALA 447 463 463 ALA ALA A . n A 1 448 ASN 448 464 464 ASN ASN A . n A 1 449 TRP 449 465 465 TRP TRP A . n A 1 450 ASN 450 466 466 ASN ASN A . n A 1 451 CYS 451 467 467 CYS CYS A . n A 1 452 ALA 452 468 468 ALA ALA A . n A 1 453 PHE 453 469 469 PHE PHE A . n A 1 454 TRP 454 470 470 TRP TRP A . n A 1 455 LYS 455 471 471 LYS LYS A . n A 1 456 LEU 456 472 472 LEU LEU A . n A 1 457 ARG 457 473 473 ARG ARG A . n A 1 458 ASP 458 474 474 ASP ASP A . n A 1 459 GLU 459 475 475 GLU GLU A . n A 1 460 TYR 460 476 476 TYR TYR A . n A 1 461 SER 461 477 477 SER SER A . n A 1 462 GLY 462 478 478 GLY GLY A . n A 1 463 ILE 463 479 479 ILE ILE A . n A 1 464 GLU 464 480 480 GLU GLU A . n A 1 465 PRO 465 481 481 PRO PRO A . n A 1 466 PRO 466 482 482 PRO PRO A . n A 1 467 VAL 467 483 483 VAL VAL A . n A 1 468 VAL 468 484 484 VAL VAL A . n A 1 469 ARG 469 485 485 ARG ARG A . n A 1 470 SER 470 486 486 SER SER A . n A 1 471 GLU 471 487 487 GLU GLU A . n A 1 472 LYS 472 488 488 LYS LYS A . n A 1 473 ASP 473 489 489 ASP ASP A . n A 1 474 PHE 474 490 490 PHE PHE A . n A 1 475 ASP 475 491 491 ASP ASP A . n A 1 476 ALA 476 492 492 ALA ALA A . n A 1 477 PRO 477 493 493 PRO PRO A . n A 1 478 ALA 478 494 494 ALA ALA A . n A 1 479 LYS 479 495 495 LYS LYS A . n A 1 480 TYR 480 496 496 TYR TYR A . n A 1 481 HIS 481 497 497 HIS HIS A . n A 1 482 ILE 482 498 498 ILE ILE A . n A 1 483 SER 483 499 499 SER SER A . n A 1 484 ALA 484 500 500 ALA ALA A . n A 1 485 ASP 485 501 501 ASP ASP A . n A 1 486 VAL 486 502 502 VAL VAL A . n A 1 487 GLU 487 503 503 GLU GLU A . n A 1 488 TYR 488 504 504 TYR TYR A . n A 1 489 LEU 489 505 505 LEU LEU A . n A 1 490 ARG 490 506 506 ARG ARG A . n A 1 491 TYR 491 507 507 TYR TYR A . n A 1 492 LEU 492 508 508 LEU LEU A . n A 1 493 VAL 493 509 509 VAL VAL A . n A 1 494 SER 494 510 510 SER SER A . n A 1 495 PHE 495 511 511 PHE PHE A . n A 1 496 ILE 496 512 512 ILE ILE A . n A 1 497 ILE 497 513 513 ILE ILE A . n A 1 498 GLN 498 514 514 GLN GLN A . n A 1 499 PHE 499 515 515 PHE PHE A . n A 1 500 GLN 500 516 516 GLN GLN A . n A 1 501 PHE 501 517 517 PHE PHE A . n A 1 502 TYR 502 518 518 TYR TYR A . n A 1 503 LYS 503 519 519 LYS LYS A . n A 1 504 SER 504 520 520 SER SER A . n A 1 505 ALA 505 521 521 ALA ALA A . n A 1 506 CYS 506 522 522 CYS CYS A . n A 1 507 ILE 507 523 523 ILE ILE A . n A 1 508 LYS 508 524 524 LYS LYS A . n A 1 509 ALA 509 525 525 ALA ALA A . n A 1 510 GLY 510 526 526 GLY GLY A . n A 1 511 GLN 511 527 527 GLN GLN A . n A 1 512 TYR 512 528 528 TYR TYR A . n A 1 513 ASP 513 529 529 ASP ASP A . n A 1 514 PRO 514 530 530 PRO PRO A . n A 1 515 ASP 515 531 531 ASP ASP A . n A 1 516 ASN 516 532 532 ASN ASN A . n A 1 517 VAL 517 533 533 VAL VAL A . n A 1 518 GLU 518 534 534 GLU GLU A . n A 1 519 LEU 519 535 535 LEU LEU A . n A 1 520 PRO 520 536 536 PRO PRO A . n A 1 521 LEU 521 537 537 LEU LEU A . n A 1 522 ASP 522 538 538 ASP ASP A . n A 1 523 ASN 523 539 539 ASN ASN A . n A 1 524 CYS 524 540 540 CYS CYS A . n A 1 525 ASP 525 541 541 ASP ASP A . n A 1 526 ILE 526 542 542 ILE ILE A . n A 1 527 TYR 527 543 543 TYR TYR A . n A 1 528 GLY 528 544 544 GLY GLY A . n A 1 529 SER 529 545 545 SER SER A . n A 1 530 ALA 530 546 546 ALA ALA A . n A 1 531 ALA 531 547 547 ALA ALA A . n A 1 532 ALA 532 548 548 ALA ALA A . n A 1 533 GLY 533 549 549 GLY GLY A . n A 1 534 ALA 534 550 550 ALA ALA A . n A 1 535 ALA 535 551 551 ALA ALA A . n A 1 536 PHE 536 552 552 PHE PHE A . n A 1 537 HIS 537 553 553 HIS HIS A . n A 1 538 ASN 538 554 554 ASN ASN A . n A 1 539 MET 539 555 555 MET MET A . n A 1 540 LEU 540 556 556 LEU LEU A . n A 1 541 SER 541 557 557 SER SER A . n A 1 542 MET 542 558 558 MET MET A . n A 1 543 GLY 543 559 559 GLY GLY A . n A 1 544 ALA 544 560 560 ALA ALA A . n A 1 545 SER 545 561 561 SER SER A . n A 1 546 LYS 546 562 562 LYS LYS A . n A 1 547 PRO 547 563 563 PRO PRO A . n A 1 548 TRP 548 564 564 TRP TRP A . n A 1 549 PRO 549 565 565 PRO PRO A . n A 1 550 ASP 550 566 566 ASP ASP A . n A 1 551 ALA 551 567 567 ALA ALA A . n A 1 552 LEU 552 568 568 LEU LEU A . n A 1 553 GLU 553 569 569 GLU GLU A . n A 1 554 ALA 554 570 570 ALA ALA A . n A 1 555 PHE 555 571 571 PHE PHE A . n A 1 556 ASN 556 572 572 ASN ASN A . n A 1 557 GLY 557 573 573 GLY GLY A . n A 1 558 GLU 558 574 574 GLU GLU A . n A 1 559 ARG 559 575 575 ARG ARG A . n A 1 560 ILE 560 576 576 ILE ILE A . n A 1 561 MET 561 577 577 MET MET A . n A 1 562 SER 562 578 578 SER SER A . n A 1 563 GLY 563 579 579 GLY GLY A . n A 1 564 LYS 564 580 580 LYS LYS A . n A 1 565 ALA 565 581 581 ALA ALA A . n A 1 566 ILE 566 582 582 ILE ILE A . n A 1 567 ALA 567 583 583 ALA ALA A . n A 1 568 GLU 568 584 584 GLU GLU A . n A 1 569 TYR 569 585 585 TYR TYR A . n A 1 570 PHE 570 586 586 PHE PHE A . n A 1 571 GLU 571 587 587 GLU GLU A . n A 1 572 PRO 572 588 588 PRO PRO A . n A 1 573 LEU 573 589 589 LEU LEU A . n A 1 574 ARG 574 590 590 ARG ARG A . n A 1 575 VAL 575 591 591 VAL VAL A . n A 1 576 TRP 576 592 592 TRP TRP A . n A 1 577 LEU 577 593 593 LEU LEU A . n A 1 578 GLU 578 594 594 GLU GLU A . n A 1 579 ALA 579 595 595 ALA ALA A . n A 1 580 GLU 580 596 596 GLU GLU A . n A 1 581 ASN 581 597 597 ASN ASN A . n A 1 582 ILE 582 598 598 ILE ILE A . n A 1 583 LYS 583 599 599 LYS LYS A . n A 1 584 ASN 584 600 600 ASN ASN A . n A 1 585 ASN 585 601 601 ASN ASN A . n A 1 586 VAL 586 602 602 VAL VAL A . n A 1 587 HIS 587 603 603 HIS HIS A . n A 1 588 ILE 588 604 604 ILE ILE A . n A 1 589 GLY 589 605 605 GLY GLY A . n A 1 590 TRP 590 606 606 TRP TRP A . n A 1 591 THR 591 607 607 THR THR A . n A 1 592 THR 592 608 608 THR THR A . n A 1 593 SER 593 609 609 SER SER A . n A 1 594 ASN 594 610 610 ASN ASN A . n A 1 595 LYS 595 611 611 LYS LYS A . n A 1 596 CYS 596 612 612 CYS CYS A . n A 1 597 VAL 597 613 613 VAL VAL A . n A 1 598 SER 598 614 614 SER SER A . n B 2 1 GLU 1 1 ? ? ? P . n B 2 2 GLY 2 2 ? ? ? P . n B 2 3 LEU 3 3 ? ? ? P . n B 2 4 PRO 4 4 ? ? ? P . n B 2 5 PRO 5 5 ? ? ? P . n B 2 6 ARG 6 6 6 ARG ARG P . n B 2 7 PRO 7 7 7 PRO PRO P . n B 2 8 LYS 8 8 8 LYS LYS P . n B 2 9 ILE 9 9 9 ILE ILE P . n B 2 10 PRO 10 10 10 PRO PRO P . n B 2 11 PRO 11 11 11 PRO PRO P . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code C 3 ZN 1 1616 1616 ZN ZN A . D 4 NAG 1 1617 1617 NAG NAG A . E 4 NAG 2 1618 1618 NAG NAG A . F 5 BMA 3 1619 1619 BMA BMA A . G 6 MAN 4 1620 1620 MAN MAN A . H 6 MAN 5 1623 1623 MAN MAN A . I 5 BMA 6 1624 1624 BMA BMA A . J 4 NAG 1 1621 1621 NAG NAG A . K 4 NAG 1 1622 1622 NAG NAG A . L 7 HOH 1 2001 2001 HOH HOH A . L 7 HOH 2 2002 2002 HOH HOH A . L 7 HOH 3 2003 2003 HOH HOH A . L 7 HOH 4 2004 2004 HOH HOH A . L 7 HOH 5 2005 2005 HOH HOH A . L 7 HOH 6 2006 2006 HOH HOH A . L 7 HOH 7 2007 2007 HOH HOH A . L 7 HOH 8 2008 2008 HOH HOH A . L 7 HOH 9 2009 2009 HOH HOH A . L 7 HOH 10 2010 2010 HOH HOH A . L 7 HOH 11 2011 2011 HOH HOH A . L 7 HOH 12 2012 2012 HOH HOH A . L 7 HOH 13 2013 2013 HOH HOH A . L 7 HOH 14 2014 2014 HOH HOH A . L 7 HOH 15 2015 2015 HOH HOH A . L 7 HOH 16 2016 2016 HOH HOH A . L 7 HOH 17 2017 2017 HOH HOH A . L 7 HOH 18 2018 2018 HOH HOH A . L 7 HOH 19 2019 2019 HOH HOH A . L 7 HOH 20 2020 2020 HOH HOH A . L 7 HOH 21 2021 2021 HOH HOH A . L 7 HOH 22 2022 2022 HOH HOH A . L 7 HOH 23 2023 2023 HOH HOH A . L 7 HOH 24 2024 2024 HOH HOH A . L 7 HOH 25 2025 2025 HOH HOH A . L 7 HOH 26 2026 2026 HOH HOH A . L 7 HOH 27 2027 2027 HOH HOH A . L 7 HOH 28 2028 2028 HOH HOH A . L 7 HOH 29 2029 2029 HOH HOH A . L 7 HOH 30 2030 2030 HOH HOH A . L 7 HOH 31 2031 2031 HOH HOH A . L 7 HOH 32 2032 2032 HOH HOH A . L 7 HOH 33 2033 2033 HOH HOH A . L 7 HOH 34 2034 2034 HOH HOH A . L 7 HOH 35 2035 2035 HOH HOH A . L 7 HOH 36 2036 2036 HOH HOH A . L 7 HOH 37 2037 2037 HOH HOH A . L 7 HOH 38 2038 2038 HOH HOH A . L 7 HOH 39 2039 2039 HOH HOH A . L 7 HOH 40 2040 2040 HOH HOH A . L 7 HOH 41 2041 2041 HOH HOH A . L 7 HOH 42 2042 2042 HOH HOH A . L 7 HOH 43 2043 2043 HOH HOH A . L 7 HOH 44 2044 2044 HOH HOH A . L 7 HOH 45 2045 2045 HOH HOH A . L 7 HOH 46 2046 2046 HOH HOH A . L 7 HOH 47 2047 2047 HOH HOH A . L 7 HOH 48 2048 2048 HOH HOH A . L 7 HOH 49 2049 2049 HOH HOH A . L 7 HOH 50 2050 2050 HOH HOH A . L 7 HOH 51 2051 2051 HOH HOH A . L 7 HOH 52 2052 2052 HOH HOH A . L 7 HOH 53 2053 2053 HOH HOH A . L 7 HOH 54 2054 2054 HOH HOH A . L 7 HOH 55 2055 2055 HOH HOH A . L 7 HOH 56 2056 2056 HOH HOH A . L 7 HOH 57 2057 2057 HOH HOH A . L 7 HOH 58 2058 2058 HOH HOH A . L 7 HOH 59 2059 2059 HOH HOH A . L 7 HOH 60 2060 2060 HOH HOH A . L 7 HOH 61 2061 2061 HOH HOH A . L 7 HOH 62 2062 2062 HOH HOH A . L 7 HOH 63 2063 2063 HOH HOH A . L 7 HOH 64 2064 2064 HOH HOH A . L 7 HOH 65 2065 2065 HOH HOH A . L 7 HOH 66 2066 2066 HOH HOH A . L 7 HOH 67 2067 2067 HOH HOH A . L 7 HOH 68 2068 2068 HOH HOH A . L 7 HOH 69 2069 2069 HOH HOH A . L 7 HOH 70 2070 2070 HOH HOH A . L 7 HOH 71 2071 2071 HOH HOH A . L 7 HOH 72 2072 2072 HOH HOH A . L 7 HOH 73 2073 2073 HOH HOH A . L 7 HOH 74 2074 2074 HOH HOH A . L 7 HOH 75 2075 2075 HOH HOH A . L 7 HOH 76 2076 2076 HOH HOH A . L 7 HOH 77 2077 2077 HOH HOH A . L 7 HOH 78 2078 2078 HOH HOH A . L 7 HOH 79 2079 2079 HOH HOH A . L 7 HOH 80 2080 2080 HOH HOH A . L 7 HOH 81 2081 2081 HOH HOH A . L 7 HOH 82 2082 2082 HOH HOH A . L 7 HOH 83 2083 2083 HOH HOH A . L 7 HOH 84 2084 2084 HOH HOH A . L 7 HOH 85 2085 2085 HOH HOH A . L 7 HOH 86 2086 2086 HOH HOH A . L 7 HOH 87 2087 2087 HOH HOH A . L 7 HOH 88 2088 2088 HOH HOH A . L 7 HOH 89 2089 2089 HOH HOH A . L 7 HOH 90 2090 2090 HOH HOH A . L 7 HOH 91 2091 2091 HOH HOH A . L 7 HOH 92 2092 2092 HOH HOH A . L 7 HOH 93 2093 2093 HOH HOH A . L 7 HOH 94 2094 2094 HOH HOH A . L 7 HOH 95 2095 2095 HOH HOH A . L 7 HOH 96 2096 2096 HOH HOH A . L 7 HOH 97 2097 2097 HOH HOH A . L 7 HOH 98 2098 2098 HOH HOH A . L 7 HOH 99 2099 2099 HOH HOH A . L 7 HOH 100 2100 2100 HOH HOH A . L 7 HOH 101 2101 2101 HOH HOH A . L 7 HOH 102 2102 2102 HOH HOH A . L 7 HOH 103 2103 2103 HOH HOH A . L 7 HOH 104 2104 2104 HOH HOH A . L 7 HOH 105 2105 2105 HOH HOH A . L 7 HOH 106 2106 2106 HOH HOH A . L 7 HOH 107 2107 2107 HOH HOH A . L 7 HOH 108 2108 2108 HOH HOH A . L 7 HOH 109 2109 2109 HOH HOH A . L 7 HOH 110 2110 2110 HOH HOH A . L 7 HOH 111 2111 2111 HOH HOH A . L 7 HOH 112 2112 2112 HOH HOH A . L 7 HOH 113 2113 2113 HOH HOH A . L 7 HOH 114 2114 2114 HOH HOH A . L 7 HOH 115 2115 2115 HOH HOH A . L 7 HOH 116 2116 2116 HOH HOH A . L 7 HOH 117 2117 2117 HOH HOH A . L 7 HOH 118 2118 2118 HOH HOH A . L 7 HOH 119 2119 2119 HOH HOH A . L 7 HOH 120 2120 2120 HOH HOH A . L 7 HOH 121 2121 2121 HOH HOH A . L 7 HOH 122 2122 2122 HOH HOH A . L 7 HOH 123 2123 2123 HOH HOH A . L 7 HOH 124 2124 2124 HOH HOH A . L 7 HOH 125 2125 2125 HOH HOH A . L 7 HOH 126 2126 2126 HOH HOH A . L 7 HOH 127 2127 2127 HOH HOH A . L 7 HOH 128 2128 2128 HOH HOH A . L 7 HOH 129 2129 2129 HOH HOH A . L 7 HOH 130 2130 2130 HOH HOH A . L 7 HOH 131 2131 2131 HOH HOH A . L 7 HOH 132 2132 2132 HOH HOH A . L 7 HOH 133 2133 2133 HOH HOH A . L 7 HOH 134 2134 2134 HOH HOH A . L 7 HOH 135 2135 2135 HOH HOH A . L 7 HOH 136 2136 2136 HOH HOH A . L 7 HOH 137 2137 2137 HOH HOH A . L 7 HOH 138 2138 2138 HOH HOH A . L 7 HOH 139 2139 2139 HOH HOH A . L 7 HOH 140 2140 2140 HOH HOH A . L 7 HOH 141 2141 2141 HOH HOH A . L 7 HOH 142 2142 2142 HOH HOH A . L 7 HOH 143 2143 2143 HOH HOH A . L 7 HOH 144 2144 2144 HOH HOH A . L 7 HOH 145 2145 2145 HOH HOH A . L 7 HOH 146 2146 2146 HOH HOH A . L 7 HOH 147 2147 2147 HOH HOH A . L 7 HOH 148 2148 2148 HOH HOH A . L 7 HOH 149 2149 2149 HOH HOH A . L 7 HOH 150 2150 2150 HOH HOH A . L 7 HOH 151 2151 2151 HOH HOH A . L 7 HOH 152 2152 2152 HOH HOH A . L 7 HOH 153 2153 2153 HOH HOH A . L 7 HOH 154 2154 2154 HOH HOH A . L 7 HOH 155 2155 2155 HOH HOH A . L 7 HOH 156 2156 2156 HOH HOH A . L 7 HOH 157 2157 2157 HOH HOH A . L 7 HOH 158 2158 2158 HOH HOH A . L 7 HOH 159 2159 2159 HOH HOH A . L 7 HOH 160 2160 2160 HOH HOH A . L 7 HOH 161 2161 2161 HOH HOH A . L 7 HOH 162 2162 2162 HOH HOH A . L 7 HOH 163 2163 2163 HOH HOH A . L 7 HOH 164 2164 2164 HOH HOH A . L 7 HOH 165 2165 2165 HOH HOH A . L 7 HOH 166 2166 2166 HOH HOH A . L 7 HOH 167 2167 2167 HOH HOH A . L 7 HOH 168 2168 2168 HOH HOH A . L 7 HOH 169 2169 2169 HOH HOH A . L 7 HOH 170 2170 2170 HOH HOH A . L 7 HOH 171 2171 2171 HOH HOH A . L 7 HOH 172 2172 2172 HOH HOH A . L 7 HOH 173 2173 2173 HOH HOH A . L 7 HOH 174 2174 2174 HOH HOH A . L 7 HOH 175 2175 2175 HOH HOH A . L 7 HOH 176 2176 2176 HOH HOH A . L 7 HOH 177 2177 2177 HOH HOH A . L 7 HOH 178 2178 2178 HOH HOH A . L 7 HOH 179 2179 2179 HOH HOH A . L 7 HOH 180 2180 2180 HOH HOH A . L 7 HOH 181 2181 2181 HOH HOH A . L 7 HOH 182 2182 2182 HOH HOH A . L 7 HOH 183 2183 2183 HOH HOH A . L 7 HOH 184 2184 2184 HOH HOH A . L 7 HOH 185 2185 2185 HOH HOH A . L 7 HOH 186 2186 2186 HOH HOH A . L 7 HOH 187 2187 2187 HOH HOH A . L 7 HOH 188 2188 2188 HOH HOH A . L 7 HOH 189 2189 2189 HOH HOH A . L 7 HOH 190 2190 2190 HOH HOH A . L 7 HOH 191 2191 2191 HOH HOH A . L 7 HOH 192 2192 2192 HOH HOH A . L 7 HOH 193 2193 2193 HOH HOH A . L 7 HOH 194 2194 2194 HOH HOH A . L 7 HOH 195 2195 2195 HOH HOH A . L 7 HOH 196 2196 2196 HOH HOH A . L 7 HOH 197 2197 2197 HOH HOH A . L 7 HOH 198 2198 2198 HOH HOH A . L 7 HOH 199 2199 2199 HOH HOH A . L 7 HOH 200 2200 2200 HOH HOH A . L 7 HOH 201 2201 2201 HOH HOH A . L 7 HOH 202 2202 2202 HOH HOH A . L 7 HOH 203 2203 2203 HOH HOH A . L 7 HOH 204 2204 2204 HOH HOH A . L 7 HOH 205 2205 2205 HOH HOH A . L 7 HOH 206 2206 2206 HOH HOH A . L 7 HOH 207 2207 2207 HOH HOH A . L 7 HOH 208 2208 2208 HOH HOH A . L 7 HOH 209 2209 2209 HOH HOH A . L 7 HOH 210 2210 2210 HOH HOH A . L 7 HOH 211 2211 2211 HOH HOH A . L 7 HOH 212 2212 2212 HOH HOH A . L 7 HOH 213 2213 2213 HOH HOH A . L 7 HOH 214 2214 2214 HOH HOH A . L 7 HOH 215 2215 2215 HOH HOH A . L 7 HOH 216 2216 2216 HOH HOH A . L 7 HOH 217 2217 2217 HOH HOH A . L 7 HOH 218 2218 2218 HOH HOH A . L 7 HOH 219 2219 2219 HOH HOH A . L 7 HOH 220 2220 2220 HOH HOH A . L 7 HOH 221 2221 2221 HOH HOH A . L 7 HOH 222 2222 2222 HOH HOH A . L 7 HOH 223 2223 2223 HOH HOH A . L 7 HOH 224 2224 2224 HOH HOH A . L 7 HOH 225 2225 2225 HOH HOH A . L 7 HOH 226 2226 2226 HOH HOH A . L 7 HOH 227 2227 2227 HOH HOH A . L 7 HOH 228 2228 2228 HOH HOH A . L 7 HOH 229 2229 2229 HOH HOH A . L 7 HOH 230 2230 2230 HOH HOH A . L 7 HOH 231 2231 2231 HOH HOH A . L 7 HOH 232 2232 2232 HOH HOH A . L 7 HOH 233 2233 2233 HOH HOH A . L 7 HOH 234 2234 2234 HOH HOH A . L 7 HOH 235 2235 2235 HOH HOH A . L 7 HOH 236 2236 2236 HOH HOH A . L 7 HOH 237 2237 2237 HOH HOH A . L 7 HOH 238 2238 2238 HOH HOH A . L 7 HOH 239 2239 2239 HOH HOH A . L 7 HOH 240 2240 2240 HOH HOH A . L 7 HOH 241 2241 2241 HOH HOH A . L 7 HOH 242 2242 2242 HOH HOH A . L 7 HOH 243 2243 2243 HOH HOH A . L 7 HOH 244 2244 2244 HOH HOH A . L 7 HOH 245 2245 2245 HOH HOH A . L 7 HOH 246 2246 2246 HOH HOH A . L 7 HOH 247 2247 2247 HOH HOH A . L 7 HOH 248 2248 2248 HOH HOH A . L 7 HOH 249 2249 2249 HOH HOH A . L 7 HOH 250 2250 2250 HOH HOH A . L 7 HOH 251 2251 2251 HOH HOH A . L 7 HOH 252 2252 2252 HOH HOH A . L 7 HOH 253 2253 2253 HOH HOH A . L 7 HOH 254 2254 2254 HOH HOH A . L 7 HOH 255 2255 2255 HOH HOH A . L 7 HOH 256 2256 2256 HOH HOH A . L 7 HOH 257 2257 2257 HOH HOH A . L 7 HOH 258 2258 2258 HOH HOH A . L 7 HOH 259 2259 2259 HOH HOH A . L 7 HOH 260 2260 2260 HOH HOH A . L 7 HOH 261 2261 2261 HOH HOH A . L 7 HOH 262 2262 2262 HOH HOH A . L 7 HOH 263 2263 2263 HOH HOH A . L 7 HOH 264 2264 2264 HOH HOH A . L 7 HOH 265 2265 2265 HOH HOH A . L 7 HOH 266 2266 2266 HOH HOH A . L 7 HOH 267 2267 2267 HOH HOH A . L 7 HOH 268 2268 2268 HOH HOH A . L 7 HOH 269 2269 2269 HOH HOH A . L 7 HOH 270 2270 2270 HOH HOH A . L 7 HOH 271 2271 2271 HOH HOH A . L 7 HOH 272 2272 2272 HOH HOH A . L 7 HOH 273 2273 2273 HOH HOH A . L 7 HOH 274 2274 2274 HOH HOH A . L 7 HOH 275 2275 2275 HOH HOH A . L 7 HOH 276 2276 2276 HOH HOH A . L 7 HOH 277 2277 2277 HOH HOH A . L 7 HOH 278 2278 2278 HOH HOH A . L 7 HOH 279 2279 2279 HOH HOH A . L 7 HOH 280 2280 2280 HOH HOH A . L 7 HOH 281 2281 2281 HOH HOH A . L 7 HOH 282 2282 2282 HOH HOH A . L 7 HOH 283 2283 2283 HOH HOH A . L 7 HOH 284 2284 2284 HOH HOH A . L 7 HOH 285 2285 2285 HOH HOH A . L 7 HOH 286 2286 2286 HOH HOH A . L 7 HOH 287 2287 2287 HOH HOH A . L 7 HOH 288 2288 2288 HOH HOH A . L 7 HOH 289 2289 2289 HOH HOH A . L 7 HOH 290 2290 2290 HOH HOH A . L 7 HOH 291 2291 2291 HOH HOH A . L 7 HOH 292 2292 2292 HOH HOH A . L 7 HOH 293 2293 2293 HOH HOH A . L 7 HOH 294 2294 2294 HOH HOH A . L 7 HOH 295 2295 2295 HOH HOH A . L 7 HOH 296 2296 2296 HOH HOH A . L 7 HOH 297 2297 2297 HOH HOH A . L 7 HOH 298 2298 2298 HOH HOH A . L 7 HOH 299 2299 2299 HOH HOH A . L 7 HOH 300 2300 2300 HOH HOH A . L 7 HOH 301 2301 2301 HOH HOH A . L 7 HOH 302 2302 2302 HOH HOH A . L 7 HOH 303 2303 2303 HOH HOH A . L 7 HOH 304 2304 2304 HOH HOH A . L 7 HOH 305 2305 2305 HOH HOH A . L 7 HOH 306 2306 2306 HOH HOH A . L 7 HOH 307 2307 2307 HOH HOH A . L 7 HOH 308 2308 2308 HOH HOH A . L 7 HOH 309 2309 2309 HOH HOH A . L 7 HOH 310 2310 2310 HOH HOH A . L 7 HOH 311 2311 2311 HOH HOH A . L 7 HOH 312 2312 2312 HOH HOH A . L 7 HOH 313 2313 2313 HOH HOH A . L 7 HOH 314 2314 2314 HOH HOH A . L 7 HOH 315 2315 2315 HOH HOH A . L 7 HOH 316 2316 2316 HOH HOH A . L 7 HOH 317 2317 2317 HOH HOH A . L 7 HOH 318 2318 2318 HOH HOH A . L 7 HOH 319 2319 2319 HOH HOH A . L 7 HOH 320 2320 2320 HOH HOH A . L 7 HOH 321 2321 2321 HOH HOH A . L 7 HOH 322 2322 2322 HOH HOH A . L 7 HOH 323 2323 2323 HOH HOH A . L 7 HOH 324 2324 2324 HOH HOH A . L 7 HOH 325 2325 2325 HOH HOH A . L 7 HOH 326 2326 2326 HOH HOH A . L 7 HOH 327 2327 2327 HOH HOH A . L 7 HOH 328 2328 2328 HOH HOH A . L 7 HOH 329 2329 2329 HOH HOH A . L 7 HOH 330 2330 2330 HOH HOH A . L 7 HOH 331 2331 2331 HOH HOH A . L 7 HOH 332 2332 2332 HOH HOH A . L 7 HOH 333 2333 2333 HOH HOH A . L 7 HOH 334 2334 2334 HOH HOH A . L 7 HOH 335 2335 2335 HOH HOH A . L 7 HOH 336 2336 2336 HOH HOH A . L 7 HOH 337 2337 2337 HOH HOH A . L 7 HOH 338 2338 2338 HOH HOH A . L 7 HOH 339 2339 2339 HOH HOH A . L 7 HOH 340 2340 2340 HOH HOH A . L 7 HOH 341 2341 2341 HOH HOH A . L 7 HOH 342 2342 2342 HOH HOH A . L 7 HOH 343 2343 2343 HOH HOH A . L 7 HOH 344 2344 2344 HOH HOH A . L 7 HOH 345 2345 2345 HOH HOH A . L 7 HOH 346 2346 2346 HOH HOH A . L 7 HOH 347 2347 2347 HOH HOH A . L 7 HOH 348 2348 2348 HOH HOH A . L 7 HOH 349 2349 2349 HOH HOH A . L 7 HOH 350 2350 2350 HOH HOH A . L 7 HOH 351 2351 2351 HOH HOH A . L 7 HOH 352 2352 2352 HOH HOH A . L 7 HOH 353 2353 2353 HOH HOH A . L 7 HOH 354 2354 2354 HOH HOH A . L 7 HOH 355 2355 2355 HOH HOH A . L 7 HOH 356 2356 2356 HOH HOH A . L 7 HOH 357 2357 2357 HOH HOH A . L 7 HOH 358 2358 2358 HOH HOH A . L 7 HOH 359 2359 2359 HOH HOH A . L 7 HOH 360 2360 2360 HOH HOH A . L 7 HOH 361 2361 2361 HOH HOH A . L 7 HOH 362 2362 2362 HOH HOH A . L 7 HOH 363 2363 2363 HOH HOH A . L 7 HOH 364 2364 2364 HOH HOH A . L 7 HOH 365 2365 2365 HOH HOH A . L 7 HOH 366 2366 2366 HOH HOH A . L 7 HOH 367 2367 2367 HOH HOH A . L 7 HOH 368 2368 2368 HOH HOH A . L 7 HOH 369 2369 2369 HOH HOH A . L 7 HOH 370 2370 2370 HOH HOH A . L 7 HOH 371 2371 2371 HOH HOH A . L 7 HOH 372 2372 2372 HOH HOH A . L 7 HOH 373 2373 2373 HOH HOH A . L 7 HOH 374 2374 2374 HOH HOH A . L 7 HOH 375 2375 2375 HOH HOH A . L 7 HOH 376 2376 2376 HOH HOH A . L 7 HOH 377 2377 2377 HOH HOH A . L 7 HOH 378 2378 2378 HOH HOH A . L 7 HOH 379 2379 2379 HOH HOH A . L 7 HOH 380 2380 2380 HOH HOH A . L 7 HOH 381 2381 2381 HOH HOH A . L 7 HOH 382 2382 2382 HOH HOH A . L 7 HOH 383 2383 2383 HOH HOH A . L 7 HOH 384 2384 2384 HOH HOH A . L 7 HOH 385 2385 2385 HOH HOH A . L 7 HOH 386 2386 2386 HOH HOH A . L 7 HOH 387 2387 2387 HOH HOH A . L 7 HOH 388 2388 2388 HOH HOH A . L 7 HOH 389 2389 2389 HOH HOH A . L 7 HOH 390 2390 2390 HOH HOH A . L 7 HOH 391 2391 2391 HOH HOH A . L 7 HOH 392 2392 2392 HOH HOH A . L 7 HOH 393 2393 2393 HOH HOH A . L 7 HOH 394 2394 2394 HOH HOH A . L 7 HOH 395 2395 2395 HOH HOH A . L 7 HOH 396 2396 2396 HOH HOH A . L 7 HOH 397 2397 2397 HOH HOH A . L 7 HOH 398 2398 2398 HOH HOH A . L 7 HOH 399 2399 2399 HOH HOH A . L 7 HOH 400 2400 2400 HOH HOH A . L 7 HOH 401 2401 2401 HOH HOH A . L 7 HOH 402 2402 2402 HOH HOH A . L 7 HOH 403 2403 2403 HOH HOH A . L 7 HOH 404 2404 2404 HOH HOH A . L 7 HOH 405 2405 2405 HOH HOH A . L 7 HOH 406 2406 2406 HOH HOH A . L 7 HOH 407 2407 2407 HOH HOH A . L 7 HOH 408 2408 2408 HOH HOH A . L 7 HOH 409 2409 2409 HOH HOH A . L 7 HOH 410 2410 2410 HOH HOH A . L 7 HOH 411 2411 2411 HOH HOH A . L 7 HOH 412 2412 2412 HOH HOH A . L 7 HOH 413 2413 2413 HOH HOH A . L 7 HOH 414 2414 2414 HOH HOH A . L 7 HOH 415 2415 2415 HOH HOH A . M 7 HOH 1 2001 2001 HOH HOH P . M 7 HOH 2 2002 2002 HOH HOH P . # _pdbx_struct_mod_residue.id 1 _pdbx_struct_mod_residue.label_asym_id A _pdbx_struct_mod_residue.label_comp_id ASN _pdbx_struct_mod_residue.label_seq_id 180 _pdbx_struct_mod_residue.auth_asym_id A _pdbx_struct_mod_residue.auth_comp_id ASN _pdbx_struct_mod_residue.auth_seq_id 196 _pdbx_struct_mod_residue.PDB_ins_code ? _pdbx_struct_mod_residue.parent_comp_id ASN _pdbx_struct_mod_residue.details 'GLYCOSYLATION SITE' # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_and_software_defined_assembly _pdbx_struct_assembly.method_details PISA _pdbx_struct_assembly.oligomeric_details dimeric _pdbx_struct_assembly.oligomeric_count 2 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G,H,I,J,K,L,M # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 1 'ABSA (A^2)' 2760 ? 1 MORE -25.6 ? 1 'SSA (A^2)' 25240 ? # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # loop_ _pdbx_struct_conn_angle.id _pdbx_struct_conn_angle.ptnr1_label_atom_id _pdbx_struct_conn_angle.ptnr1_label_alt_id _pdbx_struct_conn_angle.ptnr1_label_asym_id _pdbx_struct_conn_angle.ptnr1_label_comp_id _pdbx_struct_conn_angle.ptnr1_label_seq_id _pdbx_struct_conn_angle.ptnr1_auth_atom_id _pdbx_struct_conn_angle.ptnr1_auth_asym_id _pdbx_struct_conn_angle.ptnr1_auth_comp_id _pdbx_struct_conn_angle.ptnr1_auth_seq_id _pdbx_struct_conn_angle.ptnr1_PDB_ins_code _pdbx_struct_conn_angle.ptnr1_symmetry _pdbx_struct_conn_angle.ptnr2_label_atom_id _pdbx_struct_conn_angle.ptnr2_label_alt_id _pdbx_struct_conn_angle.ptnr2_label_asym_id _pdbx_struct_conn_angle.ptnr2_label_comp_id _pdbx_struct_conn_angle.ptnr2_label_seq_id _pdbx_struct_conn_angle.ptnr2_auth_atom_id _pdbx_struct_conn_angle.ptnr2_auth_asym_id _pdbx_struct_conn_angle.ptnr2_auth_comp_id _pdbx_struct_conn_angle.ptnr2_auth_seq_id _pdbx_struct_conn_angle.ptnr2_PDB_ins_code _pdbx_struct_conn_angle.ptnr2_symmetry _pdbx_struct_conn_angle.ptnr3_label_atom_id _pdbx_struct_conn_angle.ptnr3_label_alt_id _pdbx_struct_conn_angle.ptnr3_label_asym_id _pdbx_struct_conn_angle.ptnr3_label_comp_id _pdbx_struct_conn_angle.ptnr3_label_seq_id _pdbx_struct_conn_angle.ptnr3_auth_atom_id _pdbx_struct_conn_angle.ptnr3_auth_asym_id _pdbx_struct_conn_angle.ptnr3_auth_comp_id _pdbx_struct_conn_angle.ptnr3_auth_seq_id _pdbx_struct_conn_angle.ptnr3_PDB_ins_code _pdbx_struct_conn_angle.ptnr3_symmetry _pdbx_struct_conn_angle.value _pdbx_struct_conn_angle.value_esd 1 NE2 ? A HIS 351 ? A HIS 367 ? 1_555 ZN ? C ZN . ? A ZN 1616 ? 1_555 O ? B ILE 9 ? P ILE 9 ? 1_555 106.6 ? 2 NE2 ? A HIS 351 ? A HIS 367 ? 1_555 ZN ? C ZN . ? A ZN 1616 ? 1_555 OE1 ? A GLU 379 ? A GLU 395 ? 1_555 97.8 ? 3 O ? B ILE 9 ? P ILE 9 ? 1_555 ZN ? C ZN . ? A ZN 1616 ? 1_555 OE1 ? A GLU 379 ? A GLU 395 ? 1_555 89.5 ? 4 NE2 ? A HIS 351 ? A HIS 367 ? 1_555 ZN ? C ZN . ? A ZN 1616 ? 1_555 NE2 ? A HIS 355 ? A HIS 371 ? 1_555 104.7 ? 5 O ? B ILE 9 ? P ILE 9 ? 1_555 ZN ? C ZN . ? A ZN 1616 ? 1_555 NE2 ? A HIS 355 ? A HIS 371 ? 1_555 146.7 ? 6 OE1 ? A GLU 379 ? A GLU 395 ? 1_555 ZN ? C ZN . ? A ZN 1616 ? 1_555 NE2 ? A HIS 355 ? A HIS 371 ? 1_555 97.5 ? # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2012-10-31 2 'Structure model' 1 1 2012-12-05 3 'Structure model' 1 2 2012-12-19 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Database references' 2 3 'Structure model' 'Database references' # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal REFMAC refinement 5.5.0109 ? 1 HKL-2000 'data reduction' . ? 2 SCALEPACK 'data scaling' . ? 3 PHASER phasing . ? 4 # loop_ _pdbx_validate_close_contact.id _pdbx_validate_close_contact.PDB_model_num _pdbx_validate_close_contact.auth_atom_id_1 _pdbx_validate_close_contact.auth_asym_id_1 _pdbx_validate_close_contact.auth_comp_id_1 _pdbx_validate_close_contact.auth_seq_id_1 _pdbx_validate_close_contact.PDB_ins_code_1 _pdbx_validate_close_contact.label_alt_id_1 _pdbx_validate_close_contact.auth_atom_id_2 _pdbx_validate_close_contact.auth_asym_id_2 _pdbx_validate_close_contact.auth_comp_id_2 _pdbx_validate_close_contact.auth_seq_id_2 _pdbx_validate_close_contact.PDB_ins_code_2 _pdbx_validate_close_contact.label_alt_id_2 _pdbx_validate_close_contact.dist 1 1 ND2 A ASN 53 ? ? C1 A NAG 1622 ? ? 1.44 2 1 ND2 A ASN 311 ? ? C1 A NAG 1621 ? ? 1.45 # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 ASN A 53 ? ? -164.26 86.72 2 1 ASP A 210 ? ? -160.99 112.04 3 1 ASP A 284 ? ? -155.52 89.70 4 1 ASP A 330 ? ? -70.13 -169.19 5 1 LEU A 345 ? ? -105.72 -129.41 6 1 ASN A 572 ? ? -144.50 11.51 # _pdbx_distant_solvent_atoms.id 1 _pdbx_distant_solvent_atoms.PDB_model_num 1 _pdbx_distant_solvent_atoms.auth_atom_id O _pdbx_distant_solvent_atoms.label_alt_id ? _pdbx_distant_solvent_atoms.auth_asym_id A _pdbx_distant_solvent_atoms.auth_comp_id HOH _pdbx_distant_solvent_atoms.auth_seq_id 2054 _pdbx_distant_solvent_atoms.PDB_ins_code ? _pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 6.07 _pdbx_distant_solvent_atoms.neighbor_ligand_distance . # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 Y 1 A LYS 20 ? CG ? A LYS 4 CG 2 1 Y 1 A LYS 20 ? CD ? A LYS 4 CD 3 1 Y 1 A LYS 20 ? CE ? A LYS 4 CE 4 1 Y 1 A LYS 20 ? NZ ? A LYS 4 NZ 5 1 N 1 A NAG 1621 ? O1 ? J NAG 1 O1 6 1 N 1 A NAG 1622 ? O1 ? K NAG 1 O1 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 P GLU 1 ? B GLU 1 2 1 Y 1 P GLY 2 ? B GLY 2 3 1 Y 1 P LEU 3 ? B LEU 3 4 1 Y 1 P PRO 4 ? B PRO 4 5 1 Y 1 P PRO 5 ? B PRO 5 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 3 'ZINC ION' ZN 4 N-ACETYL-D-GLUCOSAMINE NAG 5 BETA-D-MANNOSE BMA 6 ALPHA-D-MANNOSE MAN 7 water HOH #