data_3JPY # _entry.id 3JPY # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 3JPY RCSB RCSB055011 WWPDB D_1000055011 # _pdbx_database_related.db_name PDB _pdbx_database_related.db_id 3JPW _pdbx_database_related.details 'zinc free structure of the same protein' _pdbx_database_related.content_type unspecified # _pdbx_database_status.entry_id 3JPY _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.recvd_initial_deposition_date 2009-09-04 _pdbx_database_status.status_code REL _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry ? _pdbx_database_status.pdb_format_compatible Y _pdbx_database_status.status_code_cs ? # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Karakas, E.' 1 'Simorowski, N.' 2 'Furukawa, H.' 3 # _citation.id primary _citation.title 'Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit.' _citation.journal_abbrev 'Embo J.' _citation.journal_volume 28 _citation.page_first 3910 _citation.page_last 3920 _citation.year 2009 _citation.journal_id_ASTM EMJODG _citation.country UK _citation.journal_id_ISSN 0261-4189 _citation.journal_id_CSD 0897 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 19910922 _citation.pdbx_database_id_DOI 10.1038/emboj.2009.338 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Karakas, E.' 1 primary 'Simorowski, N.' 2 primary 'Furukawa, H.' 3 # _cell.entry_id 3JPY _cell.length_a 143.368 _cell.length_b 143.368 _cell.length_c 88.467 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 120.00 _cell.Z_PDB 6 _cell.pdbx_unique_axis ? _cell.length_a_esd ? _cell.length_b_esd ? _cell.length_c_esd ? _cell.angle_alpha_esd ? _cell.angle_beta_esd ? _cell.angle_gamma_esd ? # _symmetry.entry_id 3JPY _symmetry.space_group_name_H-M 'P 31 2 1' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 152 _symmetry.space_group_name_Hall ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'Glutamate [NMDA] receptor subunit epsilon-2' 41280.820 1 ? N348D 'Amino terminal domain' ? 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 2 ? ? ? ? 3 non-polymer syn 'CHLORIDE ION' 35.453 5 ? ? ? ? 4 non-polymer syn 'SODIUM ION' 22.990 1 ? ? ? ? 5 non-polymer syn 'ZINC ION' 65.409 5 ? ? ? ? 6 water nat water 18.015 6 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name 'N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B' # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;PPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQI LDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIE NSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPS EFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRDLSF SEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRM ; _entity_poly.pdbx_seq_one_letter_code_can ;PPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQI LDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIE NSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPS EFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRDLSF SEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRM ; _entity_poly.pdbx_strand_id A _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 PRO n 1 2 PRO n 1 3 SER n 1 4 ILE n 1 5 GLY n 1 6 ILE n 1 7 ALA n 1 8 VAL n 1 9 ILE n 1 10 LEU n 1 11 VAL n 1 12 GLY n 1 13 THR n 1 14 SER n 1 15 ASP n 1 16 GLU n 1 17 VAL n 1 18 ALA n 1 19 ILE n 1 20 LYS n 1 21 ASP n 1 22 ALA n 1 23 HIS n 1 24 GLU n 1 25 LYS n 1 26 ASP n 1 27 ASP n 1 28 PHE n 1 29 HIS n 1 30 HIS n 1 31 LEU n 1 32 SER n 1 33 VAL n 1 34 VAL n 1 35 PRO n 1 36 ARG n 1 37 VAL n 1 38 GLU n 1 39 LEU n 1 40 VAL n 1 41 ALA n 1 42 MET n 1 43 ASN n 1 44 GLU n 1 45 THR n 1 46 ASP n 1 47 PRO n 1 48 LYS n 1 49 SER n 1 50 ILE n 1 51 ILE n 1 52 THR n 1 53 ARG n 1 54 ILE n 1 55 CYS n 1 56 ASP n 1 57 LEU n 1 58 MET n 1 59 SER n 1 60 ASP n 1 61 ARG n 1 62 LYS n 1 63 ILE n 1 64 GLN n 1 65 GLY n 1 66 VAL n 1 67 VAL n 1 68 PHE n 1 69 ALA n 1 70 ASP n 1 71 ASP n 1 72 THR n 1 73 ASP n 1 74 GLN n 1 75 GLU n 1 76 ALA n 1 77 ILE n 1 78 ALA n 1 79 GLN n 1 80 ILE n 1 81 LEU n 1 82 ASP n 1 83 PHE n 1 84 ILE n 1 85 SER n 1 86 ALA n 1 87 GLN n 1 88 THR n 1 89 LEU n 1 90 THR n 1 91 PRO n 1 92 ILE n 1 93 LEU n 1 94 GLY n 1 95 ILE n 1 96 HIS n 1 97 GLY n 1 98 GLY n 1 99 SER n 1 100 SER n 1 101 MET n 1 102 ILE n 1 103 MET n 1 104 ALA n 1 105 ASP n 1 106 LYS n 1 107 ASP n 1 108 GLU n 1 109 SER n 1 110 SER n 1 111 MET n 1 112 PHE n 1 113 PHE n 1 114 GLN n 1 115 PHE n 1 116 GLY n 1 117 PRO n 1 118 SER n 1 119 ILE n 1 120 GLU n 1 121 GLN n 1 122 GLN n 1 123 ALA n 1 124 SER n 1 125 VAL n 1 126 MET n 1 127 LEU n 1 128 ASN n 1 129 ILE n 1 130 MET n 1 131 GLU n 1 132 GLU n 1 133 TYR n 1 134 ASP n 1 135 TRP n 1 136 TYR n 1 137 ILE n 1 138 PHE n 1 139 SER n 1 140 ILE n 1 141 VAL n 1 142 THR n 1 143 THR n 1 144 TYR n 1 145 PHE n 1 146 PRO n 1 147 GLY n 1 148 TYR n 1 149 GLN n 1 150 ASP n 1 151 PHE n 1 152 VAL n 1 153 ASN n 1 154 LYS n 1 155 ILE n 1 156 ARG n 1 157 SER n 1 158 THR n 1 159 ILE n 1 160 GLU n 1 161 ASN n 1 162 SER n 1 163 PHE n 1 164 VAL n 1 165 GLY n 1 166 TRP n 1 167 GLU n 1 168 LEU n 1 169 GLU n 1 170 GLU n 1 171 VAL n 1 172 LEU n 1 173 LEU n 1 174 LEU n 1 175 ASP n 1 176 MET n 1 177 SER n 1 178 LEU n 1 179 ASP n 1 180 ASP n 1 181 GLY n 1 182 ASP n 1 183 SER n 1 184 LYS n 1 185 ILE n 1 186 GLN n 1 187 ASN n 1 188 GLN n 1 189 LEU n 1 190 LYS n 1 191 LYS n 1 192 LEU n 1 193 GLN n 1 194 SER n 1 195 PRO n 1 196 ILE n 1 197 ILE n 1 198 LEU n 1 199 LEU n 1 200 TYR n 1 201 CYS n 1 202 THR n 1 203 LYS n 1 204 GLU n 1 205 GLU n 1 206 ALA n 1 207 THR n 1 208 TYR n 1 209 ILE n 1 210 PHE n 1 211 GLU n 1 212 VAL n 1 213 ALA n 1 214 ASN n 1 215 SER n 1 216 VAL n 1 217 GLY n 1 218 LEU n 1 219 THR n 1 220 GLY n 1 221 TYR n 1 222 GLY n 1 223 TYR n 1 224 THR n 1 225 TRP n 1 226 ILE n 1 227 VAL n 1 228 PRO n 1 229 SER n 1 230 LEU n 1 231 VAL n 1 232 ALA n 1 233 GLY n 1 234 ASP n 1 235 THR n 1 236 ASP n 1 237 THR n 1 238 VAL n 1 239 PRO n 1 240 SER n 1 241 GLU n 1 242 PHE n 1 243 PRO n 1 244 THR n 1 245 GLY n 1 246 LEU n 1 247 ILE n 1 248 SER n 1 249 VAL n 1 250 SER n 1 251 TYR n 1 252 ASP n 1 253 GLU n 1 254 TRP n 1 255 ASP n 1 256 TYR n 1 257 GLY n 1 258 LEU n 1 259 PRO n 1 260 ALA n 1 261 ARG n 1 262 VAL n 1 263 ARG n 1 264 ASP n 1 265 GLY n 1 266 ILE n 1 267 ALA n 1 268 ILE n 1 269 ILE n 1 270 THR n 1 271 THR n 1 272 ALA n 1 273 ALA n 1 274 SER n 1 275 ASP n 1 276 MET n 1 277 LEU n 1 278 SER n 1 279 GLU n 1 280 HIS n 1 281 SER n 1 282 PHE n 1 283 ILE n 1 284 PRO n 1 285 GLU n 1 286 PRO n 1 287 LYS n 1 288 SER n 1 289 SER n 1 290 CYS n 1 291 TYR n 1 292 ASN n 1 293 THR n 1 294 HIS n 1 295 GLU n 1 296 LYS n 1 297 ARG n 1 298 ILE n 1 299 TYR n 1 300 GLN n 1 301 SER n 1 302 ASN n 1 303 MET n 1 304 LEU n 1 305 ASN n 1 306 ARG n 1 307 TYR n 1 308 LEU n 1 309 ILE n 1 310 ASN n 1 311 VAL n 1 312 THR n 1 313 PHE n 1 314 GLU n 1 315 GLY n 1 316 ARG n 1 317 ASP n 1 318 LEU n 1 319 SER n 1 320 PHE n 1 321 SER n 1 322 GLU n 1 323 ASP n 1 324 GLY n 1 325 TYR n 1 326 GLN n 1 327 MET n 1 328 HIS n 1 329 PRO n 1 330 LYS n 1 331 LEU n 1 332 VAL n 1 333 ILE n 1 334 ILE n 1 335 LEU n 1 336 LEU n 1 337 ASN n 1 338 LYS n 1 339 GLU n 1 340 ARG n 1 341 LYS n 1 342 TRP n 1 343 GLU n 1 344 ARG n 1 345 VAL n 1 346 GLY n 1 347 LYS n 1 348 TRP n 1 349 LYS n 1 350 ASP n 1 351 LYS n 1 352 SER n 1 353 LEU n 1 354 GLN n 1 355 MET n 1 356 LYS n 1 357 TYR n 1 358 TYR n 1 359 VAL n 1 360 TRP n 1 361 PRO n 1 362 ARG n 1 363 MET n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name 'brown rat,rat,rats' _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene Grin2b _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Rattus norvegicus' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 10116 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'Trichoplusia ni' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 7111 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain ? _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type ? _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name ? _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code NMDE2_RAT _struct_ref.pdbx_db_accession Q00960 _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;PPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQI LDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIE NSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPS EFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSF SEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRM ; _struct_ref.pdbx_align_begin 32 _struct_ref.pdbx_db_isoform ? # _struct_ref_seq.align_id 1 _struct_ref_seq.ref_id 1 _struct_ref_seq.pdbx_PDB_id_code 3JPY _struct_ref_seq.pdbx_strand_id A _struct_ref_seq.seq_align_beg 1 _struct_ref_seq.pdbx_seq_align_beg_ins_code ? _struct_ref_seq.seq_align_end 363 _struct_ref_seq.pdbx_seq_align_end_ins_code ? _struct_ref_seq.pdbx_db_accession Q00960 _struct_ref_seq.db_align_beg 32 _struct_ref_seq.pdbx_db_align_beg_ins_code ? _struct_ref_seq.db_align_end 394 _struct_ref_seq.pdbx_db_align_end_ins_code ? _struct_ref_seq.pdbx_auth_seq_align_beg 32 _struct_ref_seq.pdbx_auth_seq_align_end 394 # _struct_ref_seq_dif.align_id 1 _struct_ref_seq_dif.pdbx_pdb_id_code 3JPY _struct_ref_seq_dif.mon_id ASP _struct_ref_seq_dif.pdbx_pdb_strand_id A _struct_ref_seq_dif.seq_num 317 _struct_ref_seq_dif.pdbx_pdb_ins_code ? _struct_ref_seq_dif.pdbx_seq_db_name UNP _struct_ref_seq_dif.pdbx_seq_db_accession_code Q00960 _struct_ref_seq_dif.db_mon_id ASN _struct_ref_seq_dif.pdbx_seq_db_seq_num 348 _struct_ref_seq_dif.details ENGINEERED _struct_ref_seq_dif.pdbx_auth_seq_num 348 _struct_ref_seq_dif.pdbx_ordinal 1 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CL non-polymer . 'CHLORIDE ION' ? 'Cl -1' 35.453 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NA non-polymer . 'SODIUM ION' ? 'Na 1' 22.990 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 ZN non-polymer . 'ZINC ION' ? 'Zn 2' 65.409 # _exptl.entry_id 3JPY _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 6.36 _exptl_crystal.density_percent_sol 80.65 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.temp 303 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 5.5 _exptl_crystal_grow.pdbx_pH_range ? _exptl_crystal_grow.pdbx_details '3.3M NaCl, 2% PEG400, 0.1M MgCl2, 0.1M acetate, 0.1mM ZnCl2, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 303K' # _diffrn.id 1 _diffrn.ambient_temp 100.0 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type 'ADSC QUANTUM 315' _diffrn_detector.pdbx_collection_date 2009-08-06 _diffrn_detector.details ? # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator 'Si(111)' _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 1.2826 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'NSLS BEAMLINE X25' _diffrn_source.pdbx_synchrotron_site NSLS _diffrn_source.pdbx_synchrotron_beamline X25 _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list 1.2826 # _reflns.entry_id 3JPY _reflns.observed_criterion_sigma_I ? _reflns.observed_criterion_sigma_F ? _reflns.d_resolution_low 50 _reflns.d_resolution_high 3.2 _reflns.number_obs 17197 _reflns.number_all ? _reflns.percent_possible_obs 98.4 _reflns.pdbx_Rmerge_I_obs 0.078 _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI 16.8 _reflns.B_iso_Wilson_estimate 114.640 _reflns.pdbx_redundancy ? _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # _reflns_shell.d_res_high 3.20 _reflns_shell.d_res_low 3.31 _reflns_shell.percent_possible_all 94.4 _reflns_shell.Rmerge_I_obs 0.590 _reflns_shell.pdbx_Rsym_value ? _reflns_shell.meanI_over_sigI_obs 3.1 _reflns_shell.pdbx_redundancy ? _reflns_shell.percent_possible_obs ? _reflns_shell.number_unique_all ? _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_unique_obs ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 # _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.entry_id 3JPY _refine.ls_number_reflns_obs 17128 _refine.ls_number_reflns_all ? _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F 1.48 _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 29.290 _refine.ls_d_res_high 3.209 _refine.ls_percent_reflns_obs 98.18 _refine.ls_R_factor_obs 0.2056 _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work 0.2042 _refine.ls_R_factor_R_free 0.2329 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 5.02 _refine.ls_number_reflns_R_free 859 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min 0.00 _refine.occupancy_max 1.00 _refine.correlation_coeff_Fo_to_Fc ? _refine.correlation_coeff_Fo_to_Fc_free ? _refine.B_iso_mean 114.767 _refine.aniso_B[1][1] -22.374 _refine.aniso_B[2][2] -22.374 _refine.aniso_B[3][3] 44.749 _refine.aniso_B[1][2] -0.000 _refine.aniso_B[1][3] 0.000 _refine.aniso_B[2][3] 0.000 _refine.solvent_model_details 'FLAT BULK SOLVENT MODEL' _refine.solvent_model_param_ksol 0.289 _refine.solvent_model_param_bsol 94.865 _refine.pdbx_solvent_vdw_probe_radii 1.11 _refine.pdbx_solvent_ion_probe_radii ? _refine.pdbx_solvent_shrinkage_radii 0.90 _refine.pdbx_ls_cross_valid_method ? _refine.details ? _refine.pdbx_starting_model 'pdb entry 3JPW' _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values ML _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details ? _refine.pdbx_overall_ESU_R ? _refine.pdbx_overall_ESU_R_Free ? _refine.overall_SU_ML 0.70 _refine.pdbx_overall_phase_error 26.68 _refine.overall_SU_B ? _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 2606 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 39 _refine_hist.number_atoms_solvent 6 _refine_hist.number_atoms_total 2651 _refine_hist.d_res_high 3.209 _refine_hist.d_res_low 29.290 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function f_bond_d 0.007 ? ? 2711 'X-RAY DIFFRACTION' ? f_angle_d 1.041 ? ? 3712 'X-RAY DIFFRACTION' ? f_dihedral_angle_d 17.334 ? ? 882 'X-RAY DIFFRACTION' ? f_chiral_restr 0.063 ? ? 443 'X-RAY DIFFRACTION' ? f_plane_restr 0.004 ? ? 471 'X-RAY DIFFRACTION' ? # loop_ _refine_ls_shell.pdbx_refine_id _refine_ls_shell.pdbx_total_number_of_bins_used _refine_ls_shell.d_res_high _refine_ls_shell.d_res_low _refine_ls_shell.number_reflns_R_work _refine_ls_shell.R_factor_R_work _refine_ls_shell.percent_reflns_obs _refine_ls_shell.R_factor_R_free _refine_ls_shell.R_factor_R_free_error _refine_ls_shell.percent_reflns_R_free _refine_ls_shell.number_reflns_R_free _refine_ls_shell.number_reflns_all _refine_ls_shell.R_factor_all _refine_ls_shell.redundancy_reflns_obs _refine_ls_shell.number_reflns_obs 'X-RAY DIFFRACTION' . 3.209 3.4102 2600 0.3088 95.00 0.3808 . . 137 . . . . 'X-RAY DIFFRACTION' . 3.4102 3.6730 2704 0.2578 99.00 0.2847 . . 155 . . . . 'X-RAY DIFFRACTION' . 3.6730 4.0418 2677 0.2038 99.00 0.2754 . . 144 . . . . 'X-RAY DIFFRACTION' . 4.0418 4.6247 2737 0.1603 99.00 0.1659 . . 151 . . . . 'X-RAY DIFFRACTION' . 4.6247 5.8191 2744 0.1711 99.00 0.2091 . . 142 . . . . 'X-RAY DIFFRACTION' . 5.8191 29.2907 2807 0.2145 98.00 0.2338 . . 130 . . . . # _struct.entry_id 3JPY _struct.title 'Crystal structure of the zinc-bound amino terminal domain of the NMDA receptor subunit NR2B' _struct.pdbx_descriptor 'Glutamate [NMDA] receptor subunit epsilon-2' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 3JPY _struct_keywords.pdbx_keywords 'TRANSPORT PROTEIN' _struct_keywords.text ;NMDA receptor, amino terminal domain, phenylethanolamine, Cell junction, Cell membrane, Glycoprotein, Ion transport, Ionic channel, Magnesium, Membrane, Phosphoprotein, Postsynaptic cell membrane, Receptor, Synapse, Transmembrane, Transport, TRANSPORT PROTEIN ; # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 2 ? D N N 3 ? E N N 3 ? F N N 3 ? G N N 3 ? H N N 3 ? I N N 4 ? J N N 5 ? K N N 5 ? L N N 5 ? M N N 5 ? N N N 5 ? O N N 6 ? # _struct_biol.id 1 # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 PRO A 47 ? ASP A 60 ? PRO A 78 ASP A 91 1 ? 14 HELX_P HELX_P2 2 ALA A 76 ? GLN A 87 ? ALA A 107 GLN A 118 1 ? 12 HELX_P HELX_P3 3 GLY A 97 ? SER A 100 ? GLY A 128 SER A 131 5 ? 4 HELX_P HELX_P4 4 ILE A 119 ? GLU A 132 ? ILE A 150 GLU A 163 1 ? 14 HELX_P HELX_P5 5 TYR A 148 ? GLU A 160 ? TYR A 179 GLU A 191 1 ? 13 HELX_P HELX_P6 6 ILE A 185 ? LEU A 189 ? ILE A 216 LEU A 220 1 ? 5 HELX_P HELX_P7 7 LYS A 203 ? ASN A 214 ? LYS A 234 ASN A 245 1 ? 12 HELX_P HELX_P8 8 SER A 229 ? ALA A 232 ? SER A 260 ALA A 263 1 ? 4 HELX_P HELX_P9 9 LEU A 258 ? GLU A 279 ? LEU A 289 GLU A 310 1 ? 22 HELX_P HELX_P10 10 ILE A 298 ? LEU A 308 ? ILE A 329 LEU A 339 1 ? 11 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 55 SG ? ? ? 1_555 A CYS 290 SG ? ? A CYS 86 A CYS 321 1_555 ? ? ? ? ? ? ? 2.043 ? metalc1 metalc ? ? A HIS 29 ND1 ? ? ? 1_555 L ZN . ZN ? ? A HIS 60 A ZN 903 1_555 ? ? ? ? ? ? ? 1.992 ? covale1 covale ? ? A ASN 43 ND2 ? ? ? 1_555 B NAG . C1 ? ? A ASN 74 A NAG 501 1_555 ? ? ? ? ? ? ? 1.452 ? metalc2 metalc ? ? A HIS 96 NE2 ? ? ? 1_555 J ZN . ZN ? ? A HIS 127 A ZN 901 1_555 ? ? ? ? ? ? ? 2.060 ? metalc3 metalc ? ? A SER 100 O ? ? ? 1_555 I NA . NA ? ? A SER 131 A NA 701 1_555 ? ? ? ? ? ? ? 2.319 ? metalc4 metalc ? ? A PHE 115 O ? ? ? 1_555 I NA . NA ? ? A PHE 146 A NA 701 1_555 ? ? ? ? ? ? ? 2.459 ? metalc5 metalc ? ? A GLU 131 OE1 ? ? ? 1_555 M ZN . ZN ? ? A GLU 162 A ZN 904 1_555 ? ? ? ? ? ? ? 1.790 ? metalc6 metalc ? ? A GLU 132 OE2 ? ? ? 1_555 M ZN . ZN ? ? A GLU 163 A ZN 904 1_555 ? ? ? ? ? ? ? 2.173 ? metalc7 metalc ? ? A GLU 253 OE2 ? ? ? 1_555 J ZN . ZN ? ? A GLU 284 A ZN 901 1_555 ? ? ? ? ? ? ? 1.964 ? metalc8 metalc ? ? A HIS 280 ND1 ? ? ? 1_555 N ZN . ZN ? ? A HIS 311 A ZN 905 1_555 ? ? ? ? ? ? ? 2.033 ? covale2 covale ? ? A ASN 310 ND2 ? ? ? 1_555 C NAG . C1 ? ? A ASN 341 A NAG 502 1_555 ? ? ? ? ? ? ? 1.450 ? metalc9 metalc ? ? A GLU 314 OE1 ? ? ? 1_555 L ZN . ZN ? ? A GLU 345 A ZN 903 1_555 ? ? ? ? ? ? ? 2.196 ? metalc10 metalc ? ? A HIS 328 ND1 ? ? ? 1_555 K ZN . ZN ? ? A HIS 359 A ZN 902 1_555 ? ? ? ? ? ? ? 1.993 ? metalc11 metalc ? ? A ASP 350 OD1 ? ? ? 1_555 K ZN . ZN ? ? A ASP 381 A ZN 902 1_555 ? ? ? ? ? ? ? 2.190 ? metalc12 metalc ? ? A ASP 350 OD2 ? ? ? 1_555 K ZN . ZN ? ? A ASP 381 A ZN 902 1_555 ? ? ? ? ? ? ? 2.080 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? metalc ? ? covale ? ? # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 5 ? B ? 8 ? C ? 2 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? parallel A 2 3 ? parallel A 3 4 ? parallel A 4 5 ? parallel B 1 2 ? parallel B 2 3 ? parallel B 3 4 ? parallel B 4 5 ? parallel B 5 6 ? anti-parallel B 6 7 ? anti-parallel B 7 8 ? anti-parallel C 1 2 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 VAL A 34 ? VAL A 40 ? VAL A 65 VAL A 71 A 2 SER A 3 ? VAL A 11 ? SER A 34 VAL A 42 A 3 VAL A 66 ? ASP A 70 ? VAL A 97 ASP A 101 A 4 ILE A 92 ? HIS A 96 ? ILE A 123 HIS A 127 A 5 PHE A 112 ? GLN A 114 ? PHE A 143 GLN A 145 B 1 GLU A 167 ? LEU A 173 ? GLU A 198 LEU A 204 B 2 ILE A 137 ? THR A 142 ? ILE A 168 THR A 173 B 3 ILE A 196 ? TYR A 200 ? ILE A 227 TYR A 231 B 4 THR A 224 ? VAL A 227 ? THR A 255 VAL A 258 B 5 LEU A 246 ? TYR A 251 ? LEU A 277 TYR A 282 B 6 LEU A 331 ? LEU A 336 ? LEU A 362 LEU A 367 B 7 TRP A 342 ? TRP A 348 ? TRP A 373 TRP A 379 B 8 LEU A 353 ? MET A 355 ? LEU A 384 MET A 386 C 1 THR A 312 ? PHE A 313 ? THR A 343 PHE A 344 C 2 ARG A 316 ? ASP A 317 ? ARG A 347 ASP A 348 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 O ARG A 36 ? O ARG A 67 N ILE A 4 ? N ILE A 35 A 2 3 N ALA A 7 ? N ALA A 38 O VAL A 67 ? O VAL A 98 A 3 4 N VAL A 66 ? N VAL A 97 O LEU A 93 ? O LEU A 124 A 4 5 N GLY A 94 ? N GLY A 125 O PHE A 113 ? O PHE A 144 B 1 2 O GLU A 170 ? O GLU A 201 N ILE A 140 ? N ILE A 171 B 2 3 N VAL A 141 ? N VAL A 172 O LEU A 198 ? O LEU A 229 B 3 4 N ILE A 197 ? N ILE A 228 O ILE A 226 ? O ILE A 257 B 4 5 N TRP A 225 ? N TRP A 256 O ILE A 247 ? O ILE A 278 B 5 6 N SER A 248 ? N SER A 279 O ILE A 334 ? O ILE A 365 B 6 7 N ILE A 333 ? N ILE A 364 O VAL A 345 ? O VAL A 376 B 7 8 N LYS A 347 ? N LYS A 378 O GLN A 354 ? O GLN A 385 C 1 2 N PHE A 313 ? N PHE A 344 O ARG A 316 ? O ARG A 347 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE NAG A 501' AC2 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE NAG A 502' AC3 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE CL A 601' AC4 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE CL A 602' AC5 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE CL A 603' AC6 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE CL A 604' AC7 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE CL A 605' AC8 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE NA A 701' AC9 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE ZN A 901' BC1 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE ZN A 902' BC2 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE ZN A 903' BC3 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE ZN A 904' BC4 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE ZN A 905' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 1 ASN A 43 ? ASN A 74 . ? 1_555 ? 2 AC2 2 ASN A 310 ? ASN A 341 . ? 1_555 ? 3 AC2 2 THR A 312 ? THR A 343 . ? 1_555 ? 4 AC3 3 ILE A 102 ? ILE A 133 . ? 1_555 ? 5 AC3 3 GLN A 122 ? GLN A 153 . ? 1_555 ? 6 AC3 3 SER A 229 ? SER A 260 . ? 1_555 ? 7 AC4 4 HIS A 29 ? HIS A 60 . ? 1_555 ? 8 AC4 4 ARG A 263 ? ARG A 294 . ? 1_555 ? 9 AC4 4 TYR A 358 ? TYR A 389 . ? 2_545 ? 10 AC4 4 VAL A 359 ? VAL A 390 . ? 2_545 ? 11 AC5 2 GLY A 147 ? GLY A 178 . ? 1_555 ? 12 AC5 2 GLN A 149 ? GLN A 180 . ? 1_555 ? 13 AC6 1 GLY A 346 ? GLY A 377 . ? 1_555 ? 14 AC7 1 ASP A 73 ? ASP A 104 . ? 1_555 ? 15 AC8 3 SER A 100 ? SER A 131 . ? 1_555 ? 16 AC8 3 PHE A 115 ? PHE A 146 . ? 1_555 ? 17 AC8 3 GLY A 116 ? GLY A 147 . ? 1_555 ? 18 AC9 2 HIS A 96 ? HIS A 127 . ? 1_555 ? 19 AC9 2 GLU A 253 ? GLU A 284 . ? 1_555 ? 20 BC1 2 HIS A 328 ? HIS A 359 . ? 1_555 ? 21 BC1 2 ASP A 350 ? ASP A 381 . ? 1_555 ? 22 BC2 2 HIS A 29 ? HIS A 60 . ? 1_555 ? 23 BC2 2 GLU A 314 ? GLU A 345 . ? 1_555 ? 24 BC3 4 ASP A 21 ? ASP A 52 . ? 3_654 ? 25 BC3 4 HIS A 23 ? HIS A 54 . ? 3_654 ? 26 BC3 4 GLU A 131 ? GLU A 162 . ? 1_555 ? 27 BC3 4 GLU A 132 ? GLU A 163 . ? 1_555 ? 28 BC4 1 HIS A 280 ? HIS A 311 . ? 1_555 ? # _atom_sites.entry_id 3JPY _atom_sites.fract_transf_matrix[1][1] 0.006975 _atom_sites.fract_transf_matrix[1][2] 0.004027 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.008054 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.011304 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C CL N NA O S ZN # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . PRO A 1 1 ? 51.511 -61.275 47.253 1.00 177.22 ? 32 PRO A N 1 ATOM 2 C CA . PRO A 1 1 ? 52.045 -61.740 45.966 1.00 175.55 ? 32 PRO A CA 1 ATOM 3 C C . PRO A 1 1 ? 51.011 -61.654 44.833 1.00 172.71 ? 32 PRO A C 1 ATOM 4 O O . PRO A 1 1 ? 50.502 -62.699 44.405 1.00 170.91 ? 32 PRO A O 1 ATOM 5 C CB . PRO A 1 1 ? 52.391 -63.217 46.237 1.00 172.64 ? 32 PRO A CB 1 ATOM 6 C CG . PRO A 1 1 ? 52.260 -63.412 47.722 1.00 172.09 ? 32 PRO A CG 1 ATOM 7 C CD . PRO A 1 1 ? 51.277 -62.390 48.185 1.00 176.82 ? 32 PRO A CD 1 ATOM 8 N N . PRO A 1 2 ? 50.696 -60.431 44.356 1.00 165.40 ? 33 PRO A N 1 ATOM 9 C CA . PRO A 1 2 ? 49.741 -60.275 43.251 1.00 153.39 ? 33 PRO A CA 1 ATOM 10 C C . PRO A 1 2 ? 50.433 -60.462 41.904 1.00 145.15 ? 33 PRO A C 1 ATOM 11 O O . PRO A 1 2 ? 51.242 -59.621 41.521 1.00 140.93 ? 33 PRO A O 1 ATOM 12 C CB . PRO A 1 2 ? 49.264 -58.820 43.395 1.00 140.14 ? 33 PRO A CB 1 ATOM 13 C CG . PRO A 1 2 ? 49.896 -58.292 44.669 1.00 144.73 ? 33 PRO A CG 1 ATOM 14 C CD . PRO A 1 2 ? 51.113 -59.127 44.893 1.00 157.47 ? 33 PRO A CD 1 ATOM 15 N N . SER A 1 3 ? 50.129 -61.549 41.201 1.00 142.41 ? 34 SER A N 1 ATOM 16 C CA . SER A 1 3 ? 50.755 -61.807 39.907 1.00 138.12 ? 34 SER A CA 1 ATOM 17 C C . SER A 1 3 ? 49.788 -61.620 38.742 1.00 133.64 ? 34 SER A C 1 ATOM 18 O O . SER A 1 3 ? 48.582 -61.489 38.934 1.00 134.89 ? 34 SER A O 1 ATOM 19 C CB . SER A 1 3 ? 51.177 -63.277 39.777 1.00 140.60 ? 34 SER A CB 1 ATOM 20 O OG . SER A 1 3 ? 52.573 -63.440 39.979 1.00 135.41 ? 34 SER A OG 1 ATOM 21 N N . ILE A 1 4 ? 50.340 -61.603 37.535 1.00 128.78 ? 35 ILE A N 1 ATOM 22 C CA . ILE A 1 4 ? 49.556 -61.483 36.321 1.00 119.62 ? 35 ILE A CA 1 ATOM 23 C C . ILE A 1 4 ? 50.372 -61.962 35.130 1.00 116.29 ? 35 ILE A C 1 ATOM 24 O O . ILE A 1 4 ? 51.383 -61.367 34.771 1.00 115.89 ? 35 ILE A O 1 ATOM 25 C CB . ILE A 1 4 ? 49.205 -60.002 36.175 1.00 118.69 ? 35 ILE A CB 1 ATOM 26 C CG1 . ILE A 1 4 ? 48.398 -59.774 34.905 1.00 122.29 ? 35 ILE A CG1 1 ATOM 27 C CG2 . ILE A 1 4 ? 50.449 -59.158 36.139 1.00 119.60 ? 35 ILE A CG2 1 ATOM 28 C CD1 . ILE A 1 4 ? 48.029 -58.328 34.697 1.00 121.29 ? 35 ILE A CD1 1 ATOM 29 N N . GLY A 1 5 ? 49.942 -63.069 34.540 1.00 117.77 ? 36 GLY A N 1 ATOM 30 C CA . GLY A 1 5 ? 50.666 -63.665 33.438 1.00 111.80 ? 36 GLY A CA 1 ATOM 31 C C . GLY A 1 5 ? 50.529 -62.840 32.181 1.00 109.45 ? 36 GLY A C 1 ATOM 32 O O . GLY A 1 5 ? 49.431 -62.473 31.779 1.00 114.00 ? 36 GLY A O 1 ATOM 33 N N . ILE A 1 6 ? 51.655 -62.540 31.557 1.00 105.63 ? 37 ILE A N 1 ATOM 34 C CA . ILE A 1 6 ? 51.640 -61.786 30.322 1.00 101.09 ? 37 ILE A CA 1 ATOM 35 C C . ILE A 1 6 ? 52.380 -62.580 29.275 1.00 100.84 ? 37 ILE A C 1 ATOM 36 O O . ILE A 1 6 ? 53.444 -63.117 29.540 1.00 103.66 ? 37 ILE A O 1 ATOM 37 C CB . ILE A 1 6 ? 52.317 -60.430 30.504 1.00 99.11 ? 37 ILE A CB 1 ATOM 38 C CG1 . ILE A 1 6 ? 51.672 -59.690 31.677 1.00 103.28 ? 37 ILE A CG1 1 ATOM 39 C CG2 . ILE A 1 6 ? 52.250 -59.624 29.220 1.00 100.00 ? 37 ILE A CG2 1 ATOM 40 C CD1 . ILE A 1 6 ? 51.790 -58.201 31.600 1.00 103.95 ? 37 ILE A CD1 1 ATOM 41 N N . ALA A 1 7 ? 51.815 -62.687 28.087 1.00 100.61 ? 38 ALA A N 1 ATOM 42 C CA . ALA A 1 7 ? 52.511 -63.402 27.037 1.00 100.40 ? 38 ALA A CA 1 ATOM 43 C C . ALA A 1 7 ? 53.122 -62.406 26.080 1.00 102.88 ? 38 ALA A C 1 ATOM 44 O O . ALA A 1 7 ? 52.458 -61.483 25.609 1.00 103.51 ? 38 ALA A O 1 ATOM 45 C CB . ALA A 1 7 ? 51.574 -64.338 26.305 1.00 100.52 ? 38 ALA A CB 1 ATOM 46 N N . VAL A 1 8 ? 54.402 -62.579 25.803 1.00 100.05 ? 39 VAL A N 1 ATOM 47 C CA . VAL A 1 8 ? 55.031 -61.761 24.793 1.00 99.95 ? 39 VAL A CA 1 ATOM 48 C C . VAL A 1 8 ? 55.282 -62.654 23.603 1.00 99.55 ? 39 VAL A C 1 ATOM 49 O O . VAL A 1 8 ? 56.128 -63.539 23.650 1.00 99.74 ? 39 VAL A O 1 ATOM 50 C CB . VAL A 1 8 ? 56.340 -61.155 25.292 1.00 104.52 ? 39 VAL A CB 1 ATOM 51 C CG1 . VAL A 1 8 ? 57.045 -60.414 24.159 1.00 101.29 ? 39 VAL A CG1 1 ATOM 52 C CG2 . VAL A 1 8 ? 56.067 -60.229 26.473 1.00 99.08 ? 39 VAL A CG2 1 ATOM 53 N N . ILE A 1 9 ? 54.514 -62.443 22.546 1.00 99.14 ? 40 ILE A N 1 ATOM 54 C CA . ILE A 1 9 ? 54.631 -63.274 21.361 1.00 100.26 ? 40 ILE A CA 1 ATOM 55 C C . ILE A 1 9 ? 55.412 -62.502 20.320 1.00 102.94 ? 40 ILE A C 1 ATOM 56 O O . ILE A 1 9 ? 55.130 -61.324 20.063 1.00 97.47 ? 40 ILE A O 1 ATOM 57 C CB . ILE A 1 9 ? 53.256 -63.631 20.776 1.00 98.32 ? 40 ILE A CB 1 ATOM 58 C CG1 . ILE A 1 9 ? 52.266 -63.944 21.892 1.00 96.39 ? 40 ILE A CG1 1 ATOM 59 C CG2 . ILE A 1 9 ? 53.376 -64.791 19.832 1.00 93.67 ? 40 ILE A CG2 1 ATOM 60 C CD1 . ILE A 1 9 ? 52.753 -65.005 22.840 1.00 98.81 ? 40 ILE A CD1 1 ATOM 61 N N . LEU A 1 10 ? 56.396 -63.162 19.722 1.00 99.66 ? 41 LEU A N 1 ATOM 62 C CA . LEU A 1 10 ? 57.261 -62.493 18.768 1.00 101.63 ? 41 LEU A CA 1 ATOM 63 C C . LEU A 1 10 ? 57.378 -63.290 17.492 1.00 107.05 ? 41 LEU A C 1 ATOM 64 O O . LEU A 1 10 ? 58.309 -64.076 17.321 1.00 112.87 ? 41 LEU A O 1 ATOM 65 C CB . LEU A 1 10 ? 58.633 -62.234 19.387 1.00 103.02 ? 41 LEU A CB 1 ATOM 66 C CG . LEU A 1 10 ? 58.578 -61.310 20.610 1.00 99.86 ? 41 LEU A CG 1 ATOM 67 C CD1 . LEU A 1 10 ? 59.697 -61.592 21.582 1.00 97.52 ? 41 LEU A CD1 1 ATOM 68 C CD2 . LEU A 1 10 ? 58.583 -59.856 20.189 1.00 96.39 ? 41 LEU A CD2 1 ATOM 69 N N . VAL A 1 11 ? 56.410 -63.088 16.604 1.00 108.12 ? 42 VAL A N 1 ATOM 70 C CA . VAL A 1 11 ? 56.398 -63.767 15.317 1.00 113.26 ? 42 VAL A CA 1 ATOM 71 C C . VAL A 1 11 ? 57.298 -63.041 14.311 1.00 119.39 ? 42 VAL A C 1 ATOM 72 O O . VAL A 1 11 ? 57.044 -61.890 13.957 1.00 115.42 ? 42 VAL A O 1 ATOM 73 C CB . VAL A 1 11 ? 54.965 -63.901 14.749 1.00 94.75 ? 42 VAL A CB 1 ATOM 74 N N . GLY A 1 12 ? 58.361 -63.715 13.871 1.00 121.58 ? 43 GLY A N 1 ATOM 75 C CA . GLY A 1 12 ? 59.206 -63.207 12.801 1.00 122.65 ? 43 GLY A CA 1 ATOM 76 C C . GLY A 1 12 ? 60.256 -62.191 13.216 1.00 135.17 ? 43 GLY A C 1 ATOM 77 O O . GLY A 1 12 ? 61.145 -61.842 12.433 1.00 135.98 ? 43 GLY A O 1 ATOM 78 N N . THR A 1 13 ? 60.153 -61.703 14.447 1.00 138.95 ? 44 THR A N 1 ATOM 79 C CA . THR A 1 13 ? 61.128 -60.753 14.961 1.00 133.74 ? 44 THR A CA 1 ATOM 80 C C . THR A 1 13 ? 62.451 -61.466 15.145 1.00 143.18 ? 44 THR A C 1 ATOM 81 O O . THR A 1 13 ? 62.484 -62.634 15.536 1.00 144.72 ? 44 THR A O 1 ATOM 82 C CB . THR A 1 13 ? 60.694 -60.167 16.316 1.00 119.31 ? 44 THR A CB 1 ATOM 83 N N . SER A 1 14 ? 63.541 -60.768 14.840 1.00 153.90 ? 45 SER A N 1 ATOM 84 C CA . SER A 1 14 ? 64.877 -61.241 15.195 1.00 159.92 ? 45 SER A CA 1 ATOM 85 C C . SER A 1 14 ? 64.922 -61.187 16.728 1.00 162.86 ? 45 SER A C 1 ATOM 86 O O . SER A 1 14 ? 64.524 -60.182 17.326 1.00 155.72 ? 45 SER A O 1 ATOM 87 C CB . SER A 1 14 ? 65.953 -60.403 14.485 1.00 153.41 ? 45 SER A CB 1 ATOM 88 O OG . SER A 1 14 ? 65.692 -59.009 14.581 1.00 138.37 ? 45 SER A OG 1 ATOM 89 N N . ASP A 1 15 ? 65.381 -62.270 17.364 1.00 164.73 ? 46 ASP A N 1 ATOM 90 C CA . ASP A 1 15 ? 65.384 -62.347 18.832 1.00 163.75 ? 46 ASP A CA 1 ATOM 91 C C . ASP A 1 15 ? 66.471 -61.411 19.399 1.00 163.50 ? 46 ASP A C 1 ATOM 92 O O . ASP A 1 15 ? 67.605 -61.820 19.673 1.00 158.90 ? 46 ASP A O 1 ATOM 93 C CB . ASP A 1 15 ? 65.528 -63.786 19.357 1.00 164.31 ? 46 ASP A CB 1 ATOM 94 C CG . ASP A 1 15 ? 66.749 -64.506 18.796 1.00 176.37 ? 46 ASP A CG 1 ATOM 95 O OD1 . ASP A 1 15 ? 67.476 -63.906 17.974 1.00 175.20 ? 46 ASP A OD1 1 ATOM 96 O OD2 . ASP A 1 15 ? 66.982 -65.677 19.179 1.00 175.41 ? 46 ASP A OD2 1 ATOM 97 N N . GLU A 1 16 ? 66.090 -60.144 19.555 1.00 157.49 ? 47 GLU A N 1 ATOM 98 C CA . GLU A 1 16 ? 66.941 -59.101 20.112 1.00 144.07 ? 47 GLU A CA 1 ATOM 99 C C . GLU A 1 16 ? 66.310 -58.663 21.428 1.00 137.21 ? 47 GLU A C 1 ATOM 100 O O . GLU A 1 16 ? 66.818 -57.785 22.126 1.00 134.76 ? 47 GLU A O 1 ATOM 101 C CB . GLU A 1 16 ? 66.974 -57.920 19.154 1.00 142.76 ? 47 GLU A CB 1 ATOM 102 C CG . GLU A 1 16 ? 65.643 -57.175 19.091 1.00 137.59 ? 47 GLU A CG 1 ATOM 103 C CD . GLU A 1 16 ? 65.220 -56.837 17.672 1.00 138.59 ? 47 GLU A CD 1 ATOM 104 O OE1 . GLU A 1 16 ? 64.929 -55.648 17.403 1.00 127.06 ? 47 GLU A OE1 1 ATOM 105 O OE2 . GLU A 1 16 ? 65.182 -57.760 16.827 1.00 137.56 ? 47 GLU A OE2 1 ATOM 106 N N . VAL A 1 17 ? 65.181 -59.288 21.745 1.00 130.97 ? 48 VAL A N 1 ATOM 107 C CA . VAL A 1 17 ? 64.429 -58.995 22.949 1.00 121.29 ? 48 VAL A CA 1 ATOM 108 C C . VAL A 1 17 ? 64.730 -60.043 24.013 1.00 119.57 ? 48 VAL A C 1 ATOM 109 O O . VAL A 1 17 ? 64.573 -61.242 23.769 1.00 116.71 ? 48 VAL A O 1 ATOM 110 C CB . VAL A 1 17 ? 62.923 -59.007 22.643 1.00 117.45 ? 48 VAL A CB 1 ATOM 111 C CG1 . VAL A 1 17 ? 62.114 -58.788 23.903 1.00 109.25 ? 48 VAL A CG1 1 ATOM 112 C CG2 . VAL A 1 17 ? 62.593 -57.951 21.607 1.00 113.85 ? 48 VAL A CG2 1 ATOM 113 N N . ALA A 1 18 ? 65.172 -59.593 25.186 1.00 117.04 ? 49 ALA A N 1 ATOM 114 C CA . ALA A 1 18 ? 65.459 -60.503 26.298 1.00 112.78 ? 49 ALA A CA 1 ATOM 115 C C . ALA A 1 18 ? 64.669 -60.145 27.560 1.00 113.64 ? 49 ALA A C 1 ATOM 116 O O . ALA A 1 18 ? 64.839 -59.061 28.132 1.00 109.33 ? 49 ALA A O 1 ATOM 117 C CB . ALA A 1 18 ? 66.948 -60.541 26.590 1.00 108.28 ? 49 ALA A CB 1 ATOM 118 N N . ILE A 1 19 ? 63.809 -61.070 27.987 1.00 112.67 ? 50 ILE A N 1 ATOM 119 C CA . ILE A 1 19 ? 62.906 -60.844 29.118 1.00 115.22 ? 50 ILE A CA 1 ATOM 120 C C . ILE A 1 19 ? 63.370 -61.556 30.376 1.00 113.10 ? 50 ILE A C 1 ATOM 121 O O . ILE A 1 19 ? 63.845 -62.691 30.320 1.00 109.42 ? 50 ILE A O 1 ATOM 122 C CB . ILE A 1 19 ? 61.454 -61.290 28.802 1.00 115.35 ? 50 ILE A CB 1 ATOM 123 C CG1 . ILE A 1 19 ? 60.603 -60.088 28.400 1.00 105.87 ? 50 ILE A CG1 1 ATOM 124 C CG2 . ILE A 1 19 ? 60.824 -61.993 30.002 1.00 113.17 ? 50 ILE A CG2 1 ATOM 125 C CD1 . ILE A 1 19 ? 60.914 -59.577 27.026 1.00 106.58 ? 50 ILE A CD1 1 ATOM 126 N N . LYS A 1 20 ? 63.209 -60.891 31.515 1.00 112.89 ? 51 LYS A N 1 ATOM 127 C CA . LYS A 1 20 ? 63.686 -61.443 32.771 1.00 110.59 ? 51 LYS A CA 1 ATOM 128 C C . LYS A 1 20 ? 62.889 -62.723 32.974 1.00 114.56 ? 51 LYS A C 1 ATOM 129 O O . LYS A 1 20 ? 61.668 -62.703 33.120 1.00 115.81 ? 51 LYS A O 1 ATOM 130 C CB . LYS A 1 20 ? 63.719 -60.390 33.878 1.00 111.07 ? 51 LYS A CB 1 ATOM 131 C CG . LYS A 1 20 ? 64.169 -60.962 35.204 1.00 109.28 ? 51 LYS A CG 1 ATOM 132 C CD . LYS A 1 20 ? 64.655 -59.886 36.150 1.00 110.59 ? 51 LYS A CD 1 ATOM 133 C CE . LYS A 1 20 ? 63.633 -58.791 36.345 1.00 107.85 ? 51 LYS A CE 1 ATOM 134 N NZ . LYS A 1 20 ? 63.901 -58.031 37.595 1.00 112.30 ? 51 LYS A NZ 1 ATOM 135 N N . ASP A 1 21 ? 63.608 -63.835 32.944 1.00 119.54 ? 52 ASP A N 1 ATOM 136 C CA . ASP A 1 21 ? 63.172 -65.068 33.575 1.00 122.55 ? 52 ASP A CA 1 ATOM 137 C C . ASP A 1 21 ? 62.709 -64.739 35.000 1.00 126.67 ? 52 ASP A C 1 ATOM 138 O O . ASP A 1 21 ? 63.496 -64.310 35.842 1.00 126.30 ? 52 ASP A O 1 ATOM 139 C CB . ASP A 1 21 ? 64.468 -65.896 33.560 1.00 124.21 ? 52 ASP A CB 1 ATOM 140 C CG . ASP A 1 21 ? 64.464 -67.042 34.545 1.00 132.30 ? 52 ASP A CG 1 ATOM 141 O OD1 . ASP A 1 21 ? 63.925 -66.882 35.661 1.00 135.25 ? 52 ASP A OD1 1 ATOM 142 O OD2 . ASP A 1 21 ? 65.034 -68.104 34.204 1.00 127.41 ? 52 ASP A OD2 1 ATOM 143 N N . ALA A 1 22 ? 61.419 -64.919 35.261 1.00 138.60 ? 53 ALA A N 1 ATOM 144 C CA . ALA A 1 22 ? 60.843 -64.525 36.548 1.00 145.49 ? 53 ALA A CA 1 ATOM 145 C C . ALA A 1 22 ? 61.047 -65.559 37.673 1.00 147.08 ? 53 ALA A C 1 ATOM 146 O O . ALA A 1 22 ? 60.110 -66.266 38.056 1.00 132.08 ? 53 ALA A O 1 ATOM 147 C CB . ALA A 1 22 ? 59.354 -64.174 36.385 1.00 137.94 ? 53 ALA A CB 1 ATOM 148 N N . HIS A 1 23 ? 62.279 -65.645 38.185 1.00 150.36 ? 54 HIS A N 1 ATOM 149 C CA . HIS A 1 23 ? 62.571 -66.401 39.407 1.00 143.99 ? 54 HIS A CA 1 ATOM 150 C C . HIS A 1 23 ? 62.354 -65.487 40.605 1.00 144.58 ? 54 HIS A C 1 ATOM 151 O O . HIS A 1 23 ? 61.309 -65.531 41.255 1.00 141.40 ? 54 HIS A O 1 ATOM 152 C CB . HIS A 1 23 ? 64.014 -66.909 39.422 1.00 139.76 ? 54 HIS A CB 1 ATOM 153 C CG . HIS A 1 23 ? 64.234 -68.147 38.608 1.00 143.54 ? 54 HIS A CG 1 ATOM 154 N ND1 . HIS A 1 23 ? 65.424 -68.413 37.962 1.00 145.26 ? 54 HIS A ND1 1 ATOM 155 C CD2 . HIS A 1 23 ? 63.418 -69.192 38.333 1.00 143.94 ? 54 HIS A CD2 1 ATOM 156 C CE1 . HIS A 1 23 ? 65.333 -69.567 37.327 1.00 139.69 ? 54 HIS A CE1 1 ATOM 157 N NE2 . HIS A 1 23 ? 64.125 -70.061 37.535 1.00 144.72 ? 54 HIS A NE2 1 ATOM 158 N N . GLU A 1 24 ? 63.351 -64.655 40.890 1.00 146.84 ? 55 GLU A N 1 ATOM 159 C CA . GLU A 1 24 ? 63.172 -63.586 41.861 1.00 149.03 ? 55 GLU A CA 1 ATOM 160 C C . GLU A 1 24 ? 61.948 -62.769 41.443 1.00 148.34 ? 55 GLU A C 1 ATOM 161 O O . GLU A 1 24 ? 61.926 -62.159 40.369 1.00 147.95 ? 55 GLU A O 1 ATOM 162 C CB . GLU A 1 24 ? 64.423 -62.704 41.943 1.00 140.87 ? 55 GLU A CB 1 ATOM 163 N N . LYS A 1 25 ? 60.918 -62.782 42.280 1.00 144.75 ? 56 LYS A N 1 ATOM 164 C CA . LYS A 1 25 ? 59.682 -62.087 41.956 1.00 143.02 ? 56 LYS A CA 1 ATOM 165 C C . LYS A 1 25 ? 59.831 -60.577 42.150 1.00 144.38 ? 56 LYS A C 1 ATOM 166 O O . LYS A 1 25 ? 58.885 -59.897 42.551 1.00 140.89 ? 56 LYS A O 1 ATOM 167 C CB . LYS A 1 25 ? 58.524 -62.634 42.793 1.00 137.20 ? 56 LYS A CB 1 ATOM 168 N N . ASP A 1 26 ? 61.028 -60.062 41.873 1.00 144.75 ? 57 ASP A N 1 ATOM 169 C CA . ASP A 1 26 ? 61.284 -58.623 41.917 1.00 145.48 ? 57 ASP A CA 1 ATOM 170 C C . ASP A 1 26 ? 60.237 -57.902 41.087 1.00 143.06 ? 57 ASP A C 1 ATOM 171 O O . ASP A 1 26 ? 59.912 -58.336 39.986 1.00 139.63 ? 57 ASP A O 1 ATOM 172 C CB . ASP A 1 26 ? 62.672 -58.307 41.364 1.00 143.88 ? 57 ASP A CB 1 ATOM 173 C CG . ASP A 1 26 ? 63.779 -58.917 42.195 1.00 150.47 ? 57 ASP A CG 1 ATOM 174 O OD1 . ASP A 1 26 ? 63.732 -58.760 43.436 1.00 154.34 ? 57 ASP A OD1 1 ATOM 175 O OD2 . ASP A 1 26 ? 64.694 -59.548 41.613 1.00 146.67 ? 57 ASP A OD2 1 ATOM 176 N N . ASP A 1 27 ? 59.708 -56.802 41.604 1.00 138.48 ? 58 ASP A N 1 ATOM 177 C CA . ASP A 1 27 ? 58.608 -56.143 40.914 1.00 137.77 ? 58 ASP A CA 1 ATOM 178 C C . ASP A 1 27 ? 59.072 -55.329 39.699 1.00 135.92 ? 58 ASP A C 1 ATOM 179 O O . ASP A 1 27 ? 60.250 -55.005 39.562 1.00 138.32 ? 58 ASP A O 1 ATOM 180 C CB . ASP A 1 27 ? 57.745 -55.323 41.891 1.00 143.36 ? 58 ASP A CB 1 ATOM 181 C CG . ASP A 1 27 ? 58.216 -53.879 42.049 1.00 149.70 ? 58 ASP A CG 1 ATOM 182 O OD1 . ASP A 1 27 ? 57.338 -52.984 42.048 1.00 146.75 ? 58 ASP A OD1 1 ATOM 183 O OD2 . ASP A 1 27 ? 59.440 -53.633 42.181 1.00 151.80 ? 58 ASP A OD2 1 ATOM 184 N N . PHE A 1 28 ? 58.132 -55.025 38.812 1.00 133.87 ? 59 PHE A N 1 ATOM 185 C CA . PHE A 1 28 ? 58.413 -54.315 37.569 1.00 129.36 ? 59 PHE A CA 1 ATOM 186 C C . PHE A 1 28 ? 58.270 -52.815 37.782 1.00 129.40 ? 59 PHE A C 1 ATOM 187 O O . PHE A 1 28 ? 57.168 -52.317 38.011 1.00 129.46 ? 59 PHE A O 1 ATOM 188 C CB . PHE A 1 28 ? 57.438 -54.812 36.496 1.00 126.38 ? 59 PHE A CB 1 ATOM 189 C CG . PHE A 1 28 ? 57.457 -54.032 35.200 1.00 118.38 ? 59 PHE A CG 1 ATOM 190 C CD1 . PHE A 1 28 ? 57.984 -54.597 34.048 1.00 111.82 ? 59 PHE A CD1 1 ATOM 191 C CD2 . PHE A 1 28 ? 56.885 -52.771 35.116 1.00 117.29 ? 59 PHE A CD2 1 ATOM 192 C CE1 . PHE A 1 28 ? 57.970 -53.907 32.851 1.00 106.57 ? 59 PHE A CE1 1 ATOM 193 C CE2 . PHE A 1 28 ? 56.874 -52.072 33.920 1.00 112.45 ? 59 PHE A CE2 1 ATOM 194 C CZ . PHE A 1 28 ? 57.416 -52.641 32.788 1.00 108.22 ? 59 PHE A CZ 1 ATOM 195 N N . HIS A 1 29 ? 59.389 -52.102 37.724 1.00 128.92 ? 60 HIS A N 1 ATOM 196 C CA . HIS A 1 29 ? 59.374 -50.646 37.805 1.00 130.36 ? 60 HIS A CA 1 ATOM 197 C C . HIS A 1 29 ? 58.448 -50.128 38.897 1.00 133.05 ? 60 HIS A C 1 ATOM 198 O O . HIS A 1 29 ? 57.637 -49.228 38.668 1.00 131.50 ? 60 HIS A O 1 ATOM 199 C CB . HIS A 1 29 ? 58.993 -50.046 36.453 1.00 126.99 ? 60 HIS A CB 1 ATOM 200 C CG . HIS A 1 29 ? 60.090 -50.117 35.437 1.00 128.78 ? 60 HIS A CG 1 ATOM 201 N ND1 . HIS A 1 29 ? 60.854 -49.017 35.093 1.00 137.11 ? 60 HIS A ND1 1 ATOM 202 C CD2 . HIS A 1 29 ? 60.566 -51.149 34.702 1.00 117.32 ? 60 HIS A CD2 1 ATOM 203 C CE1 . HIS A 1 29 ? 61.740 -49.369 34.187 1.00 130.97 ? 60 HIS A CE1 1 ATOM 204 N NE2 . HIS A 1 29 ? 61.583 -50.659 33.922 1.00 113.18 ? 60 HIS A NE2 1 ATOM 205 N N . HIS A 1 30 ? 58.583 -50.714 40.082 1.00 136.88 ? 61 HIS A N 1 ATOM 206 C CA . HIS A 1 30 ? 57.837 -50.298 41.266 1.00 139.60 ? 61 HIS A CA 1 ATOM 207 C C . HIS A 1 30 ? 56.341 -50.182 41.044 1.00 136.97 ? 61 HIS A C 1 ATOM 208 O O . HIS A 1 30 ? 55.730 -49.169 41.388 1.00 136.43 ? 61 HIS A O 1 ATOM 209 C CB . HIS A 1 30 ? 58.399 -48.998 41.833 1.00 146.83 ? 61 HIS A CB 1 ATOM 210 C CG . HIS A 1 30 ? 59.798 -49.131 42.338 1.00 152.41 ? 61 HIS A CG 1 ATOM 211 N ND1 . HIS A 1 30 ? 60.272 -50.298 42.905 1.00 153.96 ? 61 HIS A ND1 1 ATOM 212 C CD2 . HIS A 1 30 ? 60.826 -48.251 42.369 1.00 147.66 ? 61 HIS A CD2 1 ATOM 213 C CE1 . HIS A 1 30 ? 61.532 -50.130 43.257 1.00 158.53 ? 61 HIS A CE1 1 ATOM 214 N NE2 . HIS A 1 30 ? 61.893 -48.896 42.945 1.00 157.64 ? 61 HIS A NE2 1 ATOM 215 N N . LEU A 1 31 ? 55.762 -51.229 40.467 1.00 134.32 ? 62 LEU A N 1 ATOM 216 C CA . LEU A 1 31 ? 54.318 -51.326 40.320 1.00 130.48 ? 62 LEU A CA 1 ATOM 217 C C . LEU A 1 31 ? 53.804 -52.438 41.231 1.00 129.82 ? 62 LEU A C 1 ATOM 218 O O . LEU A 1 31 ? 54.508 -53.425 41.467 1.00 126.57 ? 62 LEU A O 1 ATOM 219 C CB . LEU A 1 31 ? 53.936 -51.573 38.858 1.00 125.87 ? 62 LEU A CB 1 ATOM 220 C CG . LEU A 1 31 ? 53.996 -50.349 37.936 1.00 121.07 ? 62 LEU A CG 1 ATOM 221 C CD1 . LEU A 1 31 ? 53.957 -50.769 36.484 1.00 117.73 ? 62 LEU A CD1 1 ATOM 222 C CD2 . LEU A 1 31 ? 52.864 -49.375 38.239 1.00 123.77 ? 62 LEU A CD2 1 ATOM 223 N N . SER A 1 32 ? 52.585 -52.261 41.744 1.00 125.42 ? 63 SER A N 1 ATOM 224 C CA . SER A 1 32 ? 52.017 -53.157 42.750 1.00 120.14 ? 63 SER A CA 1 ATOM 225 C C . SER A 1 32 ? 51.861 -54.610 42.286 1.00 126.05 ? 63 SER A C 1 ATOM 226 O O . SER A 1 32 ? 51.972 -55.535 43.090 1.00 130.95 ? 63 SER A O 1 ATOM 227 C CB . SER A 1 32 ? 50.685 -52.613 43.271 1.00 111.51 ? 63 SER A CB 1 ATOM 228 N N . VAL A 1 33 ? 51.627 -54.827 40.999 1.00 123.89 ? 64 VAL A N 1 ATOM 229 C CA . VAL A 1 33 ? 51.440 -56.194 40.527 1.00 125.88 ? 64 VAL A CA 1 ATOM 230 C C . VAL A 1 33 ? 52.643 -56.745 39.768 1.00 124.42 ? 64 VAL A C 1 ATOM 231 O O . VAL A 1 33 ? 53.097 -56.155 38.788 1.00 124.81 ? 64 VAL A O 1 ATOM 232 C CB . VAL A 1 33 ? 50.202 -56.296 39.618 1.00 20.00 ? 64 VAL A CB 1 ATOM 233 C CG1 . VAL A 1 33 ? 50.070 -57.702 39.053 1.00 20.00 ? 64 VAL A CG1 1 ATOM 234 C CG2 . VAL A 1 33 ? 48.947 -55.901 40.381 1.00 20.00 ? 64 VAL A CG2 1 ATOM 235 N N . VAL A 1 34 ? 53.145 -57.889 40.226 1.00 122.56 ? 65 VAL A N 1 ATOM 236 C CA . VAL A 1 34 ? 54.261 -58.554 39.558 1.00 123.33 ? 65 VAL A CA 1 ATOM 237 C C . VAL A 1 34 ? 53.809 -59.269 38.294 1.00 122.28 ? 65 VAL A C 1 ATOM 238 O O . VAL A 1 34 ? 52.999 -60.194 38.340 1.00 124.90 ? 65 VAL A O 1 ATOM 239 C CB . VAL A 1 34 ? 54.973 -59.565 40.481 1.00 128.91 ? 65 VAL A CB 1 ATOM 240 C CG1 . VAL A 1 34 ? 55.519 -60.752 39.681 1.00 124.97 ? 65 VAL A CG1 1 ATOM 241 C CG2 . VAL A 1 34 ? 56.082 -58.876 41.250 1.00 134.41 ? 65 VAL A CG2 1 ATOM 242 N N . PRO A 1 35 ? 54.335 -58.835 37.153 1.00 118.59 ? 66 PRO A N 1 ATOM 243 C CA . PRO A 1 35 ? 54.008 -59.447 35.867 1.00 116.81 ? 66 PRO A CA 1 ATOM 244 C C . PRO A 1 35 ? 54.800 -60.720 35.680 1.00 112.39 ? 66 PRO A C 1 ATOM 245 O O . PRO A 1 35 ? 56.022 -60.647 35.653 1.00 116.88 ? 66 PRO A O 1 ATOM 246 C CB . PRO A 1 35 ? 54.491 -58.403 34.856 1.00 117.29 ? 66 PRO A CB 1 ATOM 247 C CG . PRO A 1 35 ? 54.760 -57.152 35.662 1.00 116.23 ? 66 PRO A CG 1 ATOM 248 C CD . PRO A 1 35 ? 55.166 -57.636 36.998 1.00 118.49 ? 66 PRO A CD 1 ATOM 249 N N . ARG A 1 36 ? 54.132 -61.861 35.565 1.00 111.18 ? 67 ARG A N 1 ATOM 250 C CA . ARG A 1 36 ? 54.833 -63.100 35.246 1.00 113.66 ? 67 ARG A CA 1 ATOM 251 C C . ARG A 1 36 ? 54.917 -63.242 33.730 1.00 108.58 ? 67 ARG A C 1 ATOM 252 O O . ARG A 1 36 ? 54.004 -63.769 33.101 1.00 109.07 ? 67 ARG A O 1 ATOM 253 C CB . ARG A 1 36 ? 54.128 -64.309 35.866 1.00 112.69 ? 67 ARG A CB 1 ATOM 254 N N . VAL A 1 37 ? 56.013 -62.768 33.145 1.00 106.93 ? 68 VAL A N 1 ATOM 255 C CA . VAL A 1 37 ? 56.104 -62.645 31.691 1.00 103.75 ? 68 VAL A CA 1 ATOM 256 C C . VAL A 1 37 ? 56.659 -63.884 31.016 1.00 100.40 ? 68 VAL A C 1 ATOM 257 O O . VAL A 1 37 ? 57.785 -64.285 31.286 1.00 103.83 ? 68 VAL A O 1 ATOM 258 C CB . VAL A 1 37 ? 56.959 -61.440 31.265 1.00 100.27 ? 68 VAL A CB 1 ATOM 259 C CG1 . VAL A 1 37 ? 56.955 -61.306 29.757 1.00 98.94 ? 68 VAL A CG1 1 ATOM 260 C CG2 . VAL A 1 37 ? 56.437 -60.173 31.911 1.00 99.10 ? 68 VAL A CG2 1 ATOM 261 N N . GLU A 1 38 ? 55.855 -64.475 30.133 1.00 104.34 ? 69 GLU A N 1 ATOM 262 C CA . GLU A 1 38 ? 56.258 -65.642 29.347 1.00 109.95 ? 69 GLU A CA 1 ATOM 263 C C . GLU A 1 38 ? 56.601 -65.252 27.904 1.00 110.87 ? 69 GLU A C 1 ATOM 264 O O . GLU A 1 38 ? 55.739 -64.802 27.138 1.00 107.16 ? 69 GLU A O 1 ATOM 265 C CB . GLU A 1 38 ? 55.178 -66.735 29.376 1.00 95.34 ? 69 GLU A CB 1 ATOM 266 N N . LEU A 1 39 ? 57.873 -65.423 27.551 1.00 108.75 ? 70 LEU A N 1 ATOM 267 C CA . LEU A 1 39 ? 58.374 -65.079 26.227 1.00 103.94 ? 70 LEU A CA 1 ATOM 268 C C . LEU A 1 39 ? 58.016 -66.190 25.266 1.00 105.78 ? 70 LEU A C 1 ATOM 269 O O . LEU A 1 39 ? 57.994 -67.351 25.653 1.00 115.75 ? 70 LEU A O 1 ATOM 270 C CB . LEU A 1 39 ? 59.887 -64.850 26.252 1.00 20.00 ? 70 LEU A CB 1 ATOM 271 C CG . LEU A 1 39 ? 60.549 -64.551 24.904 1.00 20.00 ? 70 LEU A CG 1 ATOM 272 C CD1 . LEU A 1 39 ? 60.016 -63.251 24.323 1.00 20.00 ? 70 LEU A CD1 1 ATOM 273 C CD2 . LEU A 1 39 ? 62.062 -64.499 25.048 1.00 20.00 ? 70 LEU A CD2 1 ATOM 274 N N . VAL A 1 40 ? 57.731 -65.845 24.017 1.00 104.13 ? 71 VAL A N 1 ATOM 275 C CA . VAL A 1 40 ? 57.447 -66.850 22.991 1.00 105.64 ? 71 VAL A CA 1 ATOM 276 C C . VAL A 1 40 ? 57.846 -66.349 21.601 1.00 111.30 ? 71 VAL A C 1 ATOM 277 O O . VAL A 1 40 ? 57.358 -65.312 21.135 1.00 112.12 ? 71 VAL A O 1 ATOM 278 C CB . VAL A 1 40 ? 55.957 -67.227 22.961 1.00 102.85 ? 71 VAL A CB 1 ATOM 279 C CG1 . VAL A 1 40 ? 55.690 -68.193 21.830 1.00 103.88 ? 71 VAL A CG1 1 ATOM 280 C CG2 . VAL A 1 40 ? 55.517 -67.811 24.291 1.00 99.68 ? 71 VAL A CG2 1 ATOM 281 N N . ALA A 1 41 ? 58.726 -67.083 20.931 1.00 109.31 ? 72 ALA A N 1 ATOM 282 C CA . ALA A 1 41 ? 59.206 -66.646 19.630 1.00 111.33 ? 72 ALA A CA 1 ATOM 283 C C . ALA A 1 41 ? 58.847 -67.643 18.544 1.00 119.58 ? 72 ALA A C 1 ATOM 284 O O . ALA A 1 41 ? 59.606 -68.567 18.246 1.00 121.31 ? 72 ALA A O 1 ATOM 285 C CB . ALA A 1 41 ? 60.692 -66.410 19.665 1.00 110.76 ? 72 ALA A CB 1 ATOM 286 N N . MET A 1 42 ? 57.671 -67.451 17.960 1.00 123.40 ? 73 MET A N 1 ATOM 287 C CA . MET A 1 42 ? 57.233 -68.306 16.865 1.00 130.30 ? 73 MET A CA 1 ATOM 288 C C . MET A 1 42 ? 58.173 -68.138 15.661 1.00 127.26 ? 73 MET A C 1 ATOM 289 O O . MET A 1 42 ? 58.697 -67.051 15.403 1.00 116.00 ? 73 MET A O 1 ATOM 290 C CB . MET A 1 42 ? 55.758 -68.046 16.486 1.00 121.74 ? 73 MET A CB 1 ATOM 291 N N . ASN A 1 43 ? 58.380 -69.241 14.948 1.00 134.76 ? 74 ASN A N 1 ATOM 292 C CA . ASN A 1 43 ? 59.215 -69.247 13.755 1.00 133.55 ? 74 ASN A CA 1 ATOM 293 C C . ASN A 1 43 ? 58.383 -69.071 12.484 1.00 134.13 ? 74 ASN A C 1 ATOM 294 O O . ASN A 1 43 ? 58.666 -68.197 11.654 1.00 124.07 ? 74 ASN A O 1 ATOM 295 C CB . ASN A 1 43 ? 60.016 -70.540 13.696 1.00 142.53 ? 74 ASN A CB 1 ATOM 296 C CG . ASN A 1 43 ? 61.103 -70.494 12.659 1.00 159.10 ? 74 ASN A CG 1 ATOM 297 O OD1 . ASN A 1 43 ? 61.666 -69.428 12.370 1.00 162.05 ? 74 ASN A OD1 1 ATOM 298 N ND2 . ASN A 1 43 ? 61.406 -71.649 12.079 1.00 165.12 ? 74 ASN A ND2 1 ATOM 299 N N . GLU A 1 44 ? 57.335 -69.888 12.367 1.00 137.36 ? 75 GLU A N 1 ATOM 300 C CA . GLU A 1 44 ? 56.367 -69.782 11.280 1.00 126.74 ? 75 GLU A CA 1 ATOM 301 C C . GLU A 1 44 ? 55.576 -68.486 11.429 1.00 124.62 ? 75 GLU A C 1 ATOM 302 O O . GLU A 1 44 ? 55.261 -68.065 12.542 1.00 124.09 ? 75 GLU A O 1 ATOM 303 C CB . GLU A 1 44 ? 55.429 -70.991 11.287 1.00 109.31 ? 75 GLU A CB 1 ATOM 304 N N . THR A 1 45 ? 55.251 -67.848 10.310 1.00 122.11 ? 76 THR A N 1 ATOM 305 C CA . THR A 1 45 ? 54.656 -66.514 10.373 1.00 124.50 ? 76 THR A CA 1 ATOM 306 C C . THR A 1 45 ? 53.317 -66.357 9.649 1.00 122.95 ? 76 THR A C 1 ATOM 307 O O . THR A 1 45 ? 52.841 -65.238 9.445 1.00 118.85 ? 76 THR A O 1 ATOM 308 C CB . THR A 1 45 ? 55.626 -65.446 9.849 1.00 127.09 ? 76 THR A CB 1 ATOM 309 O OG1 . THR A 1 45 ? 55.895 -65.681 8.460 1.00 126.22 ? 76 THR A OG1 1 ATOM 310 C CG2 . THR A 1 45 ? 56.926 -65.478 10.642 1.00 128.33 ? 76 THR A CG2 1 ATOM 311 N N . ASP A 1 46 ? 52.719 -67.473 9.252 1.00 121.48 ? 77 ASP A N 1 ATOM 312 C CA . ASP A 1 46 ? 51.391 -67.440 8.659 1.00 120.41 ? 77 ASP A CA 1 ATOM 313 C C . ASP A 1 46 ? 50.363 -67.305 9.778 1.00 119.41 ? 77 ASP A C 1 ATOM 314 O O . ASP A 1 46 ? 50.560 -67.853 10.866 1.00 117.38 ? 77 ASP A O 1 ATOM 315 C CB . ASP A 1 46 ? 51.129 -68.716 7.862 1.00 121.78 ? 77 ASP A CB 1 ATOM 316 C CG . ASP A 1 46 ? 51.181 -69.956 8.728 1.00 128.58 ? 77 ASP A CG 1 ATOM 317 O OD1 . ASP A 1 46 ? 50.248 -70.793 8.644 1.00 132.73 ? 77 ASP A OD1 1 ATOM 318 O OD2 . ASP A 1 46 ? 52.153 -70.083 9.506 1.00 126.95 ? 77 ASP A OD2 1 ATOM 319 N N . PRO A 1 47 ? 49.269 -66.563 9.521 1.00 116.07 ? 78 PRO A N 1 ATOM 320 C CA . PRO A 1 47 ? 48.197 -66.360 10.498 1.00 108.80 ? 78 PRO A CA 1 ATOM 321 C C . PRO A 1 47 ? 47.699 -67.661 11.112 1.00 110.01 ? 78 PRO A C 1 ATOM 322 O O . PRO A 1 47 ? 47.476 -67.694 12.320 1.00 106.28 ? 78 PRO A O 1 ATOM 323 C CB . PRO A 1 47 ? 47.103 -65.703 9.667 1.00 113.32 ? 78 PRO A CB 1 ATOM 324 C CG . PRO A 1 47 ? 47.856 -64.921 8.656 1.00 115.34 ? 78 PRO A CG 1 ATOM 325 C CD . PRO A 1 47 ? 49.055 -65.756 8.308 1.00 118.92 ? 78 PRO A CD 1 ATOM 326 N N . LYS A 1 48 ? 47.537 -68.714 10.317 1.00 109.57 ? 79 LYS A N 1 ATOM 327 C CA . LYS A 1 48 ? 47.082 -69.984 10.873 1.00 110.05 ? 79 LYS A CA 1 ATOM 328 C C . LYS A 1 48 ? 47.933 -70.402 12.074 1.00 107.76 ? 79 LYS A C 1 ATOM 329 O O . LYS A 1 48 ? 47.417 -70.675 13.156 1.00 103.77 ? 79 LYS A O 1 ATOM 330 C CB . LYS A 1 48 ? 47.071 -71.081 9.807 1.00 113.43 ? 79 LYS A CB 1 ATOM 331 N N . SER A 1 49 ? 49.244 -70.434 11.887 1.00 109.75 ? 80 SER A N 1 ATOM 332 C CA . SER A 1 49 ? 50.142 -70.867 12.947 1.00 110.60 ? 80 SER A CA 1 ATOM 333 C C . SER A 1 49 ? 50.007 -69.997 14.186 1.00 108.89 ? 80 SER A C 1 ATOM 334 O O . SER A 1 49 ? 50.116 -70.478 15.313 1.00 108.07 ? 80 SER A O 1 ATOM 335 C CB . SER A 1 49 ? 51.581 -70.858 12.451 1.00 110.68 ? 80 SER A CB 1 ATOM 336 O OG . SER A 1 49 ? 51.745 -71.803 11.410 1.00 117.00 ? 80 SER A OG 1 ATOM 337 N N . ILE A 1 50 ? 49.761 -68.712 13.969 1.00 109.82 ? 81 ILE A N 1 ATOM 338 C CA . ILE A 1 50 ? 49.636 -67.764 15.066 1.00 107.94 ? 81 ILE A CA 1 ATOM 339 C C . ILE A 1 50 ? 48.370 -68.004 15.873 1.00 104.80 ? 81 ILE A C 1 ATOM 340 O O . ILE A 1 50 ? 48.403 -68.039 17.099 1.00 104.61 ? 81 ILE A O 1 ATOM 341 C CB . ILE A 1 50 ? 49.641 -66.314 14.552 1.00 103.99 ? 81 ILE A CB 1 ATOM 342 C CG1 . ILE A 1 50 ? 50.858 -66.080 13.658 1.00 107.34 ? 81 ILE A CG1 1 ATOM 343 C CG2 . ILE A 1 50 ? 49.621 -65.325 15.708 1.00 93.80 ? 81 ILE A CG2 1 ATOM 344 C CD1 . ILE A 1 50 ? 50.992 -64.662 13.180 1.00 104.72 ? 81 ILE A CD1 1 ATOM 345 N N . ILE A 1 51 ? 47.248 -68.167 15.188 1.00 102.75 ? 82 ILE A N 1 ATOM 346 C CA . ILE A 1 51 ? 45.991 -68.342 15.892 1.00 103.18 ? 82 ILE A CA 1 ATOM 347 C C . ILE A 1 51 ? 46.077 -69.616 16.713 1.00 106.47 ? 82 ILE A C 1 ATOM 348 O O . ILE A 1 51 ? 45.629 -69.672 17.859 1.00 106.53 ? 82 ILE A O 1 ATOM 349 C CB . ILE A 1 51 ? 44.792 -68.372 14.922 1.00 100.74 ? 82 ILE A CB 1 ATOM 350 C CG1 . ILE A 1 51 ? 43.503 -68.736 15.656 1.00 101.89 ? 82 ILE A CG1 1 ATOM 351 C CG2 . ILE A 1 51 ? 45.047 -69.334 13.792 1.00 104.24 ? 82 ILE A CG2 1 ATOM 352 C CD1 . ILE A 1 51 ? 43.030 -67.687 16.614 1.00 95.84 ? 82 ILE A CD1 1 ATOM 353 N N . THR A 1 52 ? 46.691 -70.630 16.123 1.00 104.70 ? 83 THR A N 1 ATOM 354 C CA . THR A 1 52 ? 46.870 -71.903 16.790 1.00 104.86 ? 83 THR A CA 1 ATOM 355 C C . THR A 1 52 ? 47.760 -71.737 18.008 1.00 108.84 ? 83 THR A C 1 ATOM 356 O O . THR A 1 52 ? 47.444 -72.190 19.108 1.00 109.62 ? 83 THR A O 1 ATOM 357 C CB . THR A 1 52 ? 47.562 -72.889 15.857 1.00 103.55 ? 83 THR A CB 1 ATOM 358 O OG1 . THR A 1 52 ? 46.906 -72.885 14.586 1.00 102.99 ? 83 THR A OG1 1 ATOM 359 C CG2 . THR A 1 52 ? 47.539 -74.286 16.441 1.00 104.39 ? 83 THR A CG2 1 ATOM 360 N N . ARG A 1 53 ? 48.887 -71.078 17.797 1.00 108.98 ? 84 ARG A N 1 ATOM 361 C CA . ARG A 1 53 ? 49.912 -71.002 18.820 1.00 113.80 ? 84 ARG A CA 1 ATOM 362 C C . ARG A 1 53 ? 49.466 -70.156 20.007 1.00 110.49 ? 84 ARG A C 1 ATOM 363 O O . ARG A 1 53 ? 49.690 -70.521 21.158 1.00 113.72 ? 84 ARG A O 1 ATOM 364 C CB . ARG A 1 53 ? 51.216 -70.471 18.216 1.00 119.03 ? 84 ARG A CB 1 ATOM 365 C CG . ARG A 1 53 ? 52.409 -70.517 19.159 1.00 121.19 ? 84 ARG A CG 1 ATOM 366 C CD . ARG A 1 53 ? 52.602 -71.902 19.744 1.00 120.40 ? 84 ARG A CD 1 ATOM 367 N NE . ARG A 1 53 ? 52.840 -71.827 21.184 1.00 126.51 ? 84 ARG A NE 1 ATOM 368 C CZ . ARG A 1 53 ? 54.041 -71.706 21.743 1.00 127.41 ? 84 ARG A CZ 1 ATOM 369 N NH1 . ARG A 1 53 ? 55.127 -71.659 20.979 1.00 124.46 ? 84 ARG A NH1 1 ATOM 370 N NH2 . ARG A 1 53 ? 54.156 -71.638 23.067 1.00 122.54 ? 84 ARG A NH2 1 ATOM 371 N N . ILE A 1 54 ? 48.830 -69.028 19.725 1.00 110.26 ? 85 ILE A N 1 ATOM 372 C CA . ILE A 1 54 ? 48.361 -68.147 20.783 1.00 110.45 ? 85 ILE A CA 1 ATOM 373 C C . ILE A 1 54 ? 47.296 -68.854 21.594 1.00 113.12 ? 85 ILE A C 1 ATOM 374 O O . ILE A 1 54 ? 47.319 -68.824 22.822 1.00 115.20 ? 85 ILE A O 1 ATOM 375 C CB . ILE A 1 54 ? 47.770 -66.844 20.219 1.00 106.97 ? 85 ILE A CB 1 ATOM 376 C CG1 . ILE A 1 54 ? 48.822 -66.079 19.424 1.00 100.50 ? 85 ILE A CG1 1 ATOM 377 C CG2 . ILE A 1 54 ? 47.239 -65.967 21.336 1.00 101.66 ? 85 ILE A CG2 1 ATOM 378 C CD1 . ILE A 1 54 ? 48.332 -64.757 18.916 1.00 102.29 ? 85 ILE A CD1 1 ATOM 379 N N . CYS A 1 55 ? 46.370 -69.501 20.895 1.00 113.13 ? 86 CYS A N 1 ATOM 380 C CA . CYS A 1 55 ? 45.242 -70.163 21.539 1.00 116.05 ? 86 CYS A CA 1 ATOM 381 C C . CYS A 1 55 ? 45.656 -71.322 22.417 1.00 117.39 ? 86 CYS A C 1 ATOM 382 O O . CYS A 1 55 ? 45.252 -71.402 23.577 1.00 116.59 ? 86 CYS A O 1 ATOM 383 C CB . CYS A 1 55 ? 44.234 -70.622 20.498 1.00 118.13 ? 86 CYS A CB 1 ATOM 384 S SG . CYS A 1 55 ? 43.244 -69.240 19.924 1.00 132.95 ? 86 CYS A SG 1 ATOM 385 N N . ASP A 1 56 ? 46.461 -72.218 21.858 1.00 117.72 ? 87 ASP A N 1 ATOM 386 C CA . ASP A 1 56 ? 47.010 -73.324 22.625 1.00 121.59 ? 87 ASP A CA 1 ATOM 387 C C . ASP A 1 56 ? 47.604 -72.801 23.923 1.00 121.62 ? 87 ASP A C 1 ATOM 388 O O . ASP A 1 56 ? 47.246 -73.244 25.011 1.00 122.81 ? 87 ASP A O 1 ATOM 389 C CB . ASP A 1 56 ? 48.071 -74.070 21.810 1.00 126.04 ? 87 ASP A CB 1 ATOM 390 C CG . ASP A 1 56 ? 47.486 -75.231 21.005 1.00 137.25 ? 87 ASP A CG 1 ATOM 391 O OD1 . ASP A 1 56 ? 46.366 -75.693 21.339 1.00 133.24 ? 87 ASP A OD1 1 ATOM 392 O OD2 . ASP A 1 56 ? 48.153 -75.687 20.045 1.00 136.87 ? 87 ASP A OD2 1 ATOM 393 N N . LEU A 1 57 ? 48.502 -71.836 23.792 1.00 124.62 ? 88 LEU A N 1 ATOM 394 C CA . LEU A 1 57 ? 49.167 -71.219 24.933 1.00 123.22 ? 88 LEU A CA 1 ATOM 395 C C . LEU A 1 57 ? 48.220 -70.735 26.032 1.00 122.27 ? 88 LEU A C 1 ATOM 396 O O . LEU A 1 57 ? 48.532 -70.860 27.214 1.00 122.78 ? 88 LEU A O 1 ATOM 397 C CB . LEU A 1 57 ? 50.019 -70.047 24.455 1.00 120.33 ? 88 LEU A CB 1 ATOM 398 C CG . LEU A 1 57 ? 50.606 -69.220 25.592 1.00 120.42 ? 88 LEU A CG 1 ATOM 399 C CD1 . LEU A 1 57 ? 51.469 -70.100 26.482 1.00 121.74 ? 88 LEU A CD1 1 ATOM 400 C CD2 . LEU A 1 57 ? 51.393 -68.041 25.050 1.00 115.41 ? 88 LEU A CD2 1 ATOM 401 N N . MET A 1 58 ? 47.076 -70.175 25.641 1.00 123.50 ? 89 MET A N 1 ATOM 402 C CA . MET A 1 58 ? 46.133 -69.573 26.595 1.00 125.13 ? 89 MET A CA 1 ATOM 403 C C . MET A 1 58 ? 45.416 -70.567 27.508 1.00 126.77 ? 89 MET A C 1 ATOM 404 O O . MET A 1 58 ? 44.917 -70.195 28.577 1.00 124.72 ? 89 MET A O 1 ATOM 405 C CB . MET A 1 58 ? 45.105 -68.707 25.870 1.00 119.16 ? 89 MET A CB 1 ATOM 406 C CG . MET A 1 58 ? 45.696 -67.458 25.280 1.00 119.03 ? 89 MET A CG 1 ATOM 407 S SD . MET A 1 58 ? 44.485 -66.146 25.086 1.00 128.53 ? 89 MET A SD 1 ATOM 408 C CE . MET A 1 58 ? 44.115 -65.744 26.797 1.00 122.00 ? 89 MET A CE 1 ATOM 409 N N . SER A 1 59 ? 45.364 -71.824 27.079 1.00 124.93 ? 90 SER A N 1 ATOM 410 C CA . SER A 1 59 ? 44.798 -72.891 27.892 1.00 128.78 ? 90 SER A CA 1 ATOM 411 C C . SER A 1 59 ? 45.869 -73.557 28.765 1.00 131.70 ? 90 SER A C 1 ATOM 412 O O . SER A 1 59 ? 45.592 -73.973 29.895 1.00 130.87 ? 90 SER A O 1 ATOM 413 C CB . SER A 1 59 ? 44.116 -73.933 27.003 1.00 129.69 ? 90 SER A CB 1 ATOM 414 O OG . SER A 1 59 ? 45.067 -74.687 26.267 1.00 128.57 ? 90 SER A OG 1 ATOM 415 N N . ASP A 1 60 ? 47.087 -73.653 28.231 1.00 132.16 ? 91 ASP A N 1 ATOM 416 C CA . ASP A 1 60 ? 48.210 -74.277 28.932 1.00 127.47 ? 91 ASP A CA 1 ATOM 417 C C . ASP A 1 60 ? 48.669 -73.439 30.117 1.00 128.41 ? 91 ASP A C 1 ATOM 418 O O . ASP A 1 60 ? 48.822 -73.951 31.226 1.00 130.07 ? 91 ASP A O 1 ATOM 419 C CB . ASP A 1 60 ? 49.389 -74.480 27.983 1.00 125.88 ? 91 ASP A CB 1 ATOM 420 C CG . ASP A 1 60 ? 48.989 -75.150 26.684 1.00 134.03 ? 91 ASP A CG 1 ATOM 421 O OD1 . ASP A 1 60 ? 47.944 -75.844 26.657 1.00 132.46 ? 91 ASP A OD1 1 ATOM 422 O OD2 . ASP A 1 60 ? 49.728 -74.982 25.686 1.00 135.31 ? 91 ASP A OD2 1 ATOM 423 N N . ARG A 1 61 ? 48.900 -72.150 29.872 1.00 128.04 ? 92 ARG A N 1 ATOM 424 C CA . ARG A 1 61 ? 49.367 -71.238 30.915 1.00 126.72 ? 92 ARG A CA 1 ATOM 425 C C . ARG A 1 61 ? 48.259 -70.273 31.371 1.00 123.93 ? 92 ARG A C 1 ATOM 426 O O . ARG A 1 61 ? 47.165 -70.246 30.796 1.00 123.94 ? 92 ARG A O 1 ATOM 427 C CB . ARG A 1 61 ? 50.623 -70.483 30.451 1.00 114.24 ? 92 ARG A CB 1 ATOM 428 N N . LYS A 1 62 ? 48.539 -69.502 32.419 1.00 117.53 ? 93 LYS A N 1 ATOM 429 C CA . LYS A 1 62 ? 47.555 -68.576 32.977 1.00 118.77 ? 93 LYS A CA 1 ATOM 430 C C . LYS A 1 62 ? 47.816 -67.126 32.532 1.00 123.64 ? 93 LYS A C 1 ATOM 431 O O . LYS A 1 62 ? 48.494 -66.349 33.208 1.00 124.86 ? 93 LYS A O 1 ATOM 432 C CB . LYS A 1 62 ? 47.502 -68.699 34.503 1.00 111.57 ? 93 LYS A CB 1 ATOM 433 N N . ILE A 1 63 ? 47.244 -66.769 31.389 1.00 121.58 ? 94 ILE A N 1 ATOM 434 C CA . ILE A 1 63 ? 47.526 -65.503 30.740 1.00 109.95 ? 94 ILE A CA 1 ATOM 435 C C . ILE A 1 63 ? 46.385 -64.499 30.860 1.00 112.65 ? 94 ILE A C 1 ATOM 436 O O . ILE A 1 63 ? 45.230 -64.810 30.574 1.00 117.52 ? 94 ILE A O 1 ATOM 437 C CB . ILE A 1 63 ? 47.810 -65.751 29.273 1.00 105.76 ? 94 ILE A CB 1 ATOM 438 C CG1 . ILE A 1 63 ? 49.157 -66.444 29.138 1.00 109.07 ? 94 ILE A CG1 1 ATOM 439 C CG2 . ILE A 1 63 ? 47.786 -64.458 28.501 1.00 112.73 ? 94 ILE A CG2 1 ATOM 440 C CD1 . ILE A 1 63 ? 49.408 -66.993 27.772 1.00 115.79 ? 94 ILE A CD1 1 ATOM 441 N N . GLN A 1 64 ? 46.721 -63.283 31.264 1.00 112.48 ? 95 GLN A N 1 ATOM 442 C CA . GLN A 1 64 ? 45.722 -62.250 31.477 1.00 115.21 ? 95 GLN A CA 1 ATOM 443 C C . GLN A 1 64 ? 45.994 -61.039 30.601 1.00 109.91 ? 95 GLN A C 1 ATOM 444 O O . GLN A 1 64 ? 45.402 -59.984 30.793 1.00 107.00 ? 95 GLN A O 1 ATOM 445 C CB . GLN A 1 64 ? 45.702 -61.860 32.951 1.00 119.46 ? 95 GLN A CB 1 ATOM 446 C CG . GLN A 1 64 ? 45.828 -63.074 33.860 1.00 126.80 ? 95 GLN A CG 1 ATOM 447 C CD . GLN A 1 64 ? 45.919 -62.712 35.322 1.00 133.93 ? 95 GLN A CD 1 ATOM 448 O OE1 . GLN A 1 64 ? 46.725 -63.281 36.066 1.00 131.77 ? 95 GLN A OE1 1 ATOM 449 N NE2 . GLN A 1 64 ? 45.097 -61.755 35.747 1.00 134.71 ? 95 GLN A NE2 1 ATOM 450 N N . GLY A 1 65 ? 46.888 -61.210 29.631 1.00 107.46 ? 96 GLY A N 1 ATOM 451 C CA . GLY A 1 65 ? 47.256 -60.147 28.715 1.00 104.79 ? 96 GLY A CA 1 ATOM 452 C C . GLY A 1 65 ? 48.306 -60.613 27.725 1.00 103.18 ? 96 GLY A C 1 ATOM 453 O O . GLY A 1 65 ? 49.101 -61.505 28.021 1.00 103.13 ? 96 GLY A O 1 ATOM 454 N N . VAL A 1 66 ? 48.311 -60.014 26.543 1.00 98.59 ? 97 VAL A N 1 ATOM 455 C CA . VAL A 1 66 ? 49.259 -60.398 25.513 1.00 97.43 ? 97 VAL A CA 1 ATOM 456 C C . VAL A 1 66 ? 49.894 -59.176 24.861 1.00 99.78 ? 97 VAL A C 1 ATOM 457 O O . VAL A 1 66 ? 49.200 -58.313 24.324 1.00 100.55 ? 97 VAL A O 1 ATOM 458 C CB . VAL A 1 66 ? 48.576 -61.236 24.419 1.00 94.33 ? 97 VAL A CB 1 ATOM 459 C CG1 . VAL A 1 66 ? 49.579 -61.657 23.369 1.00 91.28 ? 97 VAL A CG1 1 ATOM 460 C CG2 . VAL A 1 66 ? 47.917 -62.443 25.028 1.00 98.27 ? 97 VAL A CG2 1 ATOM 461 N N . VAL A 1 67 ? 51.217 -59.095 24.917 1.00 100.63 ? 98 VAL A N 1 ATOM 462 C CA . VAL A 1 67 ? 51.935 -58.124 24.108 1.00 95.69 ? 98 VAL A CA 1 ATOM 463 C C . VAL A 1 67 ? 52.463 -58.866 22.877 1.00 95.59 ? 98 VAL A C 1 ATOM 464 O O . VAL A 1 67 ? 53.149 -59.889 22.993 1.00 95.86 ? 98 VAL A O 1 ATOM 465 C CB . VAL A 1 67 ? 53.077 -57.456 24.888 1.00 90.17 ? 98 VAL A CB 1 ATOM 466 C CG1 . VAL A 1 67 ? 53.804 -56.519 23.992 1.00 89.41 ? 98 VAL A CG1 1 ATOM 467 C CG2 . VAL A 1 67 ? 52.545 -56.707 26.097 1.00 86.83 ? 98 VAL A CG2 1 ATOM 468 N N . PHE A 1 68 ? 52.119 -58.368 21.698 1.00 88.98 ? 99 PHE A N 1 ATOM 469 C CA . PHE A 1 68 ? 52.385 -59.116 20.483 1.00 91.30 ? 99 PHE A CA 1 ATOM 470 C C . PHE A 1 68 ? 53.056 -58.283 19.398 1.00 95.82 ? 99 PHE A C 1 ATOM 471 O O . PHE A 1 68 ? 52.547 -57.229 19.015 1.00 96.04 ? 99 PHE A O 1 ATOM 472 C CB . PHE A 1 68 ? 51.084 -59.698 19.936 1.00 92.37 ? 99 PHE A CB 1 ATOM 473 C CG . PHE A 1 68 ? 51.250 -60.375 18.620 1.00 93.24 ? 99 PHE A CG 1 ATOM 474 C CD1 . PHE A 1 68 ? 51.420 -61.748 18.550 1.00 98.04 ? 99 PHE A CD1 1 ATOM 475 C CD2 . PHE A 1 68 ? 51.277 -59.638 17.452 1.00 90.02 ? 99 PHE A CD2 1 ATOM 476 C CE1 . PHE A 1 68 ? 51.601 -62.379 17.330 1.00 96.78 ? 99 PHE A CE1 1 ATOM 477 C CE2 . PHE A 1 68 ? 51.456 -60.254 16.234 1.00 93.31 ? 99 PHE A CE2 1 ATOM 478 C CZ . PHE A 1 68 ? 51.618 -61.629 16.170 1.00 98.62 ? 99 PHE A CZ 1 ATOM 479 N N . ALA A 1 69 ? 54.185 -58.769 18.886 1.00 97.38 ? 100 ALA A N 1 ATOM 480 C CA . ALA A 1 69 ? 54.891 -58.081 17.805 1.00 96.54 ? 100 ALA A CA 1 ATOM 481 C C . ALA A 1 69 ? 55.229 -59.039 16.691 1.00 98.55 ? 100 ALA A C 1 ATOM 482 O O . ALA A 1 69 ? 55.422 -60.228 16.928 1.00 102.31 ? 100 ALA A O 1 ATOM 483 C CB . ALA A 1 69 ? 56.160 -57.431 18.316 1.00 94.63 ? 100 ALA A CB 1 ATOM 484 N N . ASP A 1 70 ? 55.314 -58.515 15.475 1.00 99.09 ? 101 ASP A N 1 ATOM 485 C CA . ASP A 1 70 ? 55.714 -59.317 14.324 1.00 109.21 ? 101 ASP A CA 1 ATOM 486 C C . ASP A 1 70 ? 56.480 -58.442 13.339 1.00 112.20 ? 101 ASP A C 1 ATOM 487 O O . ASP A 1 70 ? 56.232 -57.241 13.265 1.00 112.06 ? 101 ASP A O 1 ATOM 488 C CB . ASP A 1 70 ? 54.487 -59.942 13.647 1.00 109.10 ? 101 ASP A CB 1 ATOM 489 C CG . ASP A 1 70 ? 53.619 -58.910 12.927 1.00 113.71 ? 101 ASP A CG 1 ATOM 490 O OD1 . ASP A 1 70 ? 53.993 -58.475 11.814 1.00 116.49 ? 101 ASP A OD1 1 ATOM 491 O OD2 . ASP A 1 70 ? 52.551 -58.540 13.464 1.00 113.82 ? 101 ASP A OD2 1 ATOM 492 N N . ASP A 1 71 ? 57.404 -59.030 12.583 1.00 114.33 ? 102 ASP A N 1 ATOM 493 C CA . ASP A 1 71 ? 58.168 -58.259 11.600 1.00 119.25 ? 102 ASP A CA 1 ATOM 494 C C . ASP A 1 71 ? 57.656 -58.477 10.175 1.00 118.95 ? 102 ASP A C 1 ATOM 495 O O . ASP A 1 71 ? 58.348 -58.175 9.203 1.00 126.11 ? 102 ASP A O 1 ATOM 496 C CB . ASP A 1 71 ? 59.669 -58.572 11.691 1.00 121.09 ? 102 ASP A CB 1 ATOM 497 N N . THR A 1 72 ? 56.440 -58.996 10.057 1.00 112.83 ? 103 THR A N 1 ATOM 498 C CA . THR A 1 72 ? 55.848 -59.273 8.752 1.00 113.67 ? 103 THR A CA 1 ATOM 499 C C . THR A 1 72 ? 55.070 -58.065 8.254 1.00 110.66 ? 103 THR A C 1 ATOM 500 O O . THR A 1 72 ? 54.922 -57.086 8.974 1.00 109.75 ? 103 THR A O 1 ATOM 501 C CB . THR A 1 72 ? 54.897 -60.479 8.815 1.00 117.19 ? 103 THR A CB 1 ATOM 502 O OG1 . THR A 1 72 ? 53.640 -60.074 9.374 1.00 119.28 ? 103 THR A OG1 1 ATOM 503 C CG2 . THR A 1 72 ? 55.503 -61.592 9.666 1.00 114.62 ? 103 THR A CG2 1 ATOM 504 N N . ASP A 1 73 ? 54.577 -58.138 7.022 1.00 110.18 ? 104 ASP A N 1 ATOM 505 C CA . ASP A 1 73 ? 53.775 -57.061 6.447 1.00 111.85 ? 104 ASP A CA 1 ATOM 506 C C . ASP A 1 73 ? 52.338 -57.510 6.225 1.00 115.05 ? 104 ASP A C 1 ATOM 507 O O . ASP A 1 73 ? 51.691 -57.104 5.258 1.00 117.28 ? 104 ASP A O 1 ATOM 508 C CB . ASP A 1 73 ? 54.373 -56.581 5.120 1.00 113.36 ? 104 ASP A CB 1 ATOM 509 C CG . ASP A 1 73 ? 55.345 -55.427 5.295 1.00 117.24 ? 104 ASP A CG 1 ATOM 510 O OD1 . ASP A 1 73 ? 55.458 -54.916 6.430 1.00 120.88 ? 104 ASP A OD1 1 ATOM 511 O OD2 . ASP A 1 73 ? 55.994 -55.031 4.297 1.00 113.30 ? 104 ASP A OD2 1 ATOM 512 N N . GLN A 1 74 ? 51.841 -58.347 7.128 1.00 113.86 ? 105 GLN A N 1 ATOM 513 C CA . GLN A 1 74 ? 50.508 -58.910 6.991 1.00 111.49 ? 105 GLN A CA 1 ATOM 514 C C . GLN A 1 74 ? 49.520 -58.228 7.924 1.00 108.03 ? 105 GLN A C 1 ATOM 515 O O . GLN A 1 74 ? 49.461 -58.545 9.107 1.00 106.86 ? 105 GLN A O 1 ATOM 516 C CB . GLN A 1 74 ? 50.549 -60.402 7.296 1.00 110.74 ? 105 GLN A CB 1 ATOM 517 C CG . GLN A 1 74 ? 51.889 -61.043 7.004 1.00 112.96 ? 105 GLN A CG 1 ATOM 518 C CD . GLN A 1 74 ? 51.900 -62.523 7.326 1.00 122.26 ? 105 GLN A CD 1 ATOM 519 O OE1 . GLN A 1 74 ? 50.910 -63.222 7.103 1.00 131.25 ? 105 GLN A OE1 1 ATOM 520 N NE2 . GLN A 1 74 ? 53.022 -63.012 7.849 1.00 118.46 ? 105 GLN A NE2 1 ATOM 521 N N . GLU A 1 75 ? 48.747 -57.289 7.393 1.00 107.36 ? 106 GLU A N 1 ATOM 522 C CA . GLU A 1 75 ? 47.696 -56.651 8.173 1.00 108.71 ? 106 GLU A CA 1 ATOM 523 C C . GLU A 1 75 ? 46.757 -57.736 8.686 1.00 110.93 ? 106 GLU A C 1 ATOM 524 O O . GLU A 1 75 ? 46.074 -57.566 9.697 1.00 112.24 ? 106 GLU A O 1 ATOM 525 C CB . GLU A 1 75 ? 46.927 -55.634 7.322 1.00 111.43 ? 106 GLU A CB 1 ATOM 526 C CG . GLU A 1 75 ? 46.193 -56.231 6.108 1.00 119.36 ? 106 GLU A CG 1 ATOM 527 C CD . GLU A 1 75 ? 47.122 -56.588 4.935 1.00 129.75 ? 106 GLU A CD 1 ATOM 528 O OE1 . GLU A 1 75 ? 48.289 -56.114 4.909 1.00 128.73 ? 106 GLU A OE1 1 ATOM 529 O OE2 . GLU A 1 75 ? 46.675 -57.341 4.031 1.00 127.22 ? 106 GLU A OE2 1 ATOM 530 N N . ALA A 1 76 ? 46.736 -58.853 7.966 1.00 107.90 ? 107 ALA A N 1 ATOM 531 C CA . ALA A 1 76 ? 45.981 -60.034 8.354 1.00 103.15 ? 107 ALA A CA 1 ATOM 532 C C . ALA A 1 76 ? 46.102 -60.336 9.843 1.00 100.19 ? 107 ALA A C 1 ATOM 533 O O . ALA A 1 76 ? 45.110 -60.528 10.522 1.00 103.59 ? 107 ALA A O 1 ATOM 534 C CB . ALA A 1 76 ? 46.453 -61.224 7.546 1.00 110.85 ? 107 ALA A CB 1 ATOM 535 N N . ILE A 1 77 ? 47.324 -60.394 10.348 1.00 100.56 ? 108 ILE A N 1 ATOM 536 C CA . ILE A 1 77 ? 47.545 -60.693 11.752 1.00 98.40 ? 108 ILE A CA 1 ATOM 537 C C . ILE A 1 77 ? 46.573 -59.958 12.675 1.00 99.51 ? 108 ILE A C 1 ATOM 538 O O . ILE A 1 77 ? 46.220 -60.464 13.735 1.00 98.30 ? 108 ILE A O 1 ATOM 539 C CB . ILE A 1 77 ? 48.962 -60.298 12.181 1.00 101.37 ? 108 ILE A CB 1 ATOM 540 C CG1 . ILE A 1 77 ? 49.992 -60.668 11.107 1.00 106.37 ? 108 ILE A CG1 1 ATOM 541 C CG2 . ILE A 1 77 ? 49.291 -60.938 13.501 1.00 99.47 ? 108 ILE A CG2 1 ATOM 542 C CD1 . ILE A 1 77 ? 50.477 -62.082 11.175 1.00 106.56 ? 108 ILE A CD1 1 ATOM 543 N N . ALA A 1 78 ? 46.153 -58.760 12.277 1.00 100.05 ? 109 ALA A N 1 ATOM 544 C CA . ALA A 1 78 ? 45.299 -57.921 13.119 1.00 94.68 ? 109 ALA A CA 1 ATOM 545 C C . ALA A 1 78 ? 43.905 -58.519 13.327 1.00 102.62 ? 109 ALA A C 1 ATOM 546 O O . ALA A 1 78 ? 43.368 -58.501 14.436 1.00 103.24 ? 109 ALA A O 1 ATOM 547 C CB . ALA A 1 78 ? 45.201 -56.535 12.536 1.00 95.22 ? 109 ALA A CB 1 ATOM 548 N N . GLN A 1 79 ? 43.322 -59.047 12.256 1.00 104.39 ? 110 GLN A N 1 ATOM 549 C CA . GLN A 1 79 ? 42.056 -59.765 12.341 1.00 97.99 ? 110 GLN A CA 1 ATOM 550 C C . GLN A 1 79 ? 42.113 -60.871 13.390 1.00 97.21 ? 110 GLN A C 1 ATOM 551 O O . GLN A 1 79 ? 41.310 -60.880 14.324 1.00 97.54 ? 110 GLN A O 1 ATOM 552 C CB . GLN A 1 79 ? 41.708 -60.378 10.990 1.00 99.63 ? 110 GLN A CB 1 ATOM 553 C CG . GLN A 1 79 ? 41.789 -59.413 9.839 1.00 104.78 ? 110 GLN A CG 1 ATOM 554 C CD . GLN A 1 79 ? 40.804 -58.274 9.980 1.00 117.67 ? 110 GLN A CD 1 ATOM 555 O OE1 . GLN A 1 79 ? 41.149 -57.109 9.778 1.00 122.82 ? 110 GLN A OE1 1 ATOM 556 N NE2 . GLN A 1 79 ? 39.565 -58.604 10.336 1.00 125.90 ? 110 GLN A NE2 1 ATOM 557 N N . ILE A 1 80 ? 43.054 -61.804 13.230 1.00 93.45 ? 111 ILE A N 1 ATOM 558 C CA . ILE A 1 80 ? 43.177 -62.919 14.166 1.00 92.83 ? 111 ILE A CA 1 ATOM 559 C C . ILE A 1 80 ? 43.303 -62.385 15.601 1.00 92.91 ? 111 ILE A C 1 ATOM 560 O O . ILE A 1 80 ? 42.754 -62.959 16.535 1.00 94.31 ? 111 ILE A O 1 ATOM 561 C CB . ILE A 1 80 ? 44.323 -63.928 13.798 1.00 64.10 ? 111 ILE A CB 1 ATOM 562 N N . LEU A 1 81 ? 43.976 -61.257 15.779 1.00 93.65 ? 112 LEU A N 1 ATOM 563 C CA . LEU A 1 81 ? 44.211 -60.757 17.132 1.00 95.33 ? 112 LEU A CA 1 ATOM 564 C C . LEU A 1 81 ? 42.981 -60.115 17.736 1.00 92.95 ? 112 LEU A C 1 ATOM 565 O O . LEU A 1 81 ? 42.702 -60.284 18.918 1.00 92.93 ? 112 LEU A O 1 ATOM 566 C CB . LEU A 1 81 ? 45.382 -59.775 17.173 1.00 94.43 ? 112 LEU A CB 1 ATOM 567 C CG . LEU A 1 81 ? 46.768 -60.291 16.803 1.00 91.70 ? 112 LEU A CG 1 ATOM 568 C CD1 . LEU A 1 81 ? 47.764 -59.235 17.200 1.00 95.66 ? 112 LEU A CD1 1 ATOM 569 C CD2 . LEU A 1 81 ? 47.085 -61.620 17.486 1.00 85.51 ? 112 LEU A CD2 1 ATOM 570 N N . ASP A 1 82 ? 42.256 -59.357 16.928 1.00 94.57 ? 113 ASP A N 1 ATOM 571 C CA . ASP A 1 82 ? 41.047 -58.721 17.414 1.00 97.93 ? 113 ASP A CA 1 ATOM 572 C C . ASP A 1 82 ? 40.048 -59.801 17.764 1.00 96.49 ? 113 ASP A C 1 ATOM 573 O O . ASP A 1 82 ? 39.331 -59.712 18.757 1.00 92.45 ? 113 ASP A O 1 ATOM 574 C CB . ASP A 1 82 ? 40.448 -57.823 16.344 1.00 101.39 ? 113 ASP A CB 1 ATOM 575 C CG . ASP A 1 82 ? 39.292 -56.991 16.871 1.00 111.44 ? 113 ASP A CG 1 ATOM 576 O OD1 . ASP A 1 82 ? 39.441 -56.397 17.961 1.00 110.62 ? 113 ASP A OD1 1 ATOM 577 O OD2 . ASP A 1 82 ? 38.237 -56.925 16.198 1.00 116.61 ? 113 ASP A OD2 1 ATOM 578 N N . PHE A 1 83 ? 40.011 -60.829 16.927 1.00 96.81 ? 114 PHE A N 1 ATOM 579 C CA . PHE A 1 83 ? 39.158 -61.970 17.173 1.00 92.92 ? 114 PHE A CA 1 ATOM 580 C C . PHE A 1 83 ? 39.442 -62.603 18.527 1.00 90.21 ? 114 PHE A C 1 ATOM 581 O O . PHE A 1 83 ? 38.539 -62.780 19.335 1.00 91.77 ? 114 PHE A O 1 ATOM 582 C CB . PHE A 1 83 ? 39.327 -63.007 16.075 1.00 93.34 ? 114 PHE A CB 1 ATOM 583 C CG . PHE A 1 83 ? 38.459 -64.200 16.262 1.00 93.77 ? 114 PHE A CG 1 ATOM 584 C CD1 . PHE A 1 83 ? 37.086 -64.062 16.278 1.00 88.46 ? 114 PHE A CD1 1 ATOM 585 C CD2 . PHE A 1 83 ? 39.006 -65.454 16.446 1.00 93.26 ? 114 PHE A CD2 1 ATOM 586 C CE1 . PHE A 1 83 ? 36.275 -65.152 16.466 1.00 92.38 ? 114 PHE A CE1 1 ATOM 587 C CE2 . PHE A 1 83 ? 38.192 -66.549 16.636 1.00 91.95 ? 114 PHE A CE2 1 ATOM 588 C CZ . PHE A 1 83 ? 36.827 -66.396 16.644 1.00 89.24 ? 114 PHE A CZ 1 ATOM 589 N N . ILE A 1 84 ? 40.696 -62.947 18.777 1.00 88.36 ? 115 ILE A N 1 ATOM 590 C CA . ILE A 1 84 ? 41.056 -63.550 20.054 1.00 92.22 ? 115 ILE A CA 1 ATOM 591 C C . ILE A 1 84 ? 40.797 -62.626 21.250 1.00 92.56 ? 115 ILE A C 1 ATOM 592 O O . ILE A 1 84 ? 40.334 -63.063 22.300 1.00 91.52 ? 115 ILE A O 1 ATOM 593 C CB . ILE A 1 84 ? 42.529 -63.992 20.075 1.00 93.47 ? 115 ILE A CB 1 ATOM 594 C CG1 . ILE A 1 84 ? 42.802 -65.008 18.977 1.00 93.87 ? 115 ILE A CG1 1 ATOM 595 C CG2 . ILE A 1 84 ? 42.896 -64.592 21.416 1.00 92.38 ? 115 ILE A CG2 1 ATOM 596 C CD1 . ILE A 1 84 ? 44.216 -65.480 18.978 1.00 98.97 ? 115 ILE A CD1 1 ATOM 597 N N . SER A 1 85 ? 41.111 -61.347 21.107 1.00 93.71 ? 116 SER A N 1 ATOM 598 C CA . SER A 1 85 ? 40.941 -60.449 22.227 1.00 94.22 ? 116 SER A CA 1 ATOM 599 C C . SER A 1 85 ? 39.485 -60.480 22.611 1.00 97.72 ? 116 SER A C 1 ATOM 600 O O . SER A 1 85 ? 39.154 -60.437 23.790 1.00 98.17 ? 116 SER A O 1 ATOM 601 C CB . SER A 1 85 ? 41.336 -59.029 21.859 1.00 96.73 ? 116 SER A CB 1 ATOM 602 O OG . SER A 1 85 ? 40.901 -58.132 22.865 1.00 99.52 ? 116 SER A OG 1 ATOM 603 N N . ALA A 1 86 ? 38.625 -60.556 21.594 1.00 99.33 ? 117 ALA A N 1 ATOM 604 C CA . ALA A 1 86 ? 37.169 -60.596 21.761 1.00 98.50 ? 117 ALA A CA 1 ATOM 605 C C . ALA A 1 86 ? 36.685 -61.900 22.404 1.00 97.37 ? 117 ALA A C 1 ATOM 606 O O . ALA A 1 86 ? 36.011 -61.887 23.434 1.00 98.00 ? 117 ALA A O 1 ATOM 607 C CB . ALA A 1 86 ? 36.478 -60.380 20.416 1.00 95.34 ? 117 ALA A CB 1 ATOM 608 N N . GLN A 1 87 ? 37.034 -63.026 21.795 1.00 94.05 ? 118 GLN A N 1 ATOM 609 C CA . GLN A 1 87 ? 36.597 -64.314 22.310 1.00 94.56 ? 118 GLN A CA 1 ATOM 610 C C . GLN A 1 87 ? 36.983 -64.514 23.765 1.00 95.26 ? 118 GLN A C 1 ATOM 611 O O . GLN A 1 87 ? 36.296 -65.215 24.494 1.00 101.08 ? 118 GLN A O 1 ATOM 612 C CB . GLN A 1 87 ? 37.156 -65.460 21.470 1.00 94.55 ? 118 GLN A CB 1 ATOM 613 C CG . GLN A 1 87 ? 36.543 -65.573 20.087 1.00 93.85 ? 118 GLN A CG 1 ATOM 614 C CD . GLN A 1 87 ? 35.040 -65.736 20.138 1.00 104.64 ? 118 GLN A CD 1 ATOM 615 O OE1 . GLN A 1 87 ? 34.290 -64.831 19.756 1.00 105.59 ? 118 GLN A OE1 1 ATOM 616 N NE2 . GLN A 1 87 ? 34.586 -66.887 20.625 1.00 107.88 ? 118 GLN A NE2 1 ATOM 617 N N . THR A 1 88 ? 38.075 -63.892 24.195 1.00 99.93 ? 119 THR A N 1 ATOM 618 C CA . THR A 1 88 ? 38.635 -64.177 25.516 1.00 101.29 ? 119 THR A CA 1 ATOM 619 C C . THR A 1 88 ? 38.641 -62.978 26.450 1.00 102.08 ? 119 THR A C 1 ATOM 620 O O . THR A 1 88 ? 39.195 -63.047 27.548 1.00 104.30 ? 119 THR A O 1 ATOM 621 C CB . THR A 1 88 ? 40.077 -64.664 25.417 1.00 98.09 ? 119 THR A CB 1 ATOM 622 O OG1 . THR A 1 88 ? 40.929 -63.539 25.190 1.00 104.82 ? 119 THR A OG1 1 ATOM 623 C CG2 . THR A 1 88 ? 40.236 -65.684 24.285 1.00 95.86 ? 119 THR A CG2 1 ATOM 624 N N . LEU A 1 89 ? 38.045 -61.878 26.011 1.00 103.22 ? 120 LEU A N 1 ATOM 625 C CA . LEU A 1 89 ? 37.971 -60.683 26.840 1.00 108.03 ? 120 LEU A CA 1 ATOM 626 C C . LEU A 1 89 ? 39.309 -60.380 27.506 1.00 110.25 ? 120 LEU A C 1 ATOM 627 O O . LEU A 1 89 ? 39.369 -59.966 28.666 1.00 110.52 ? 120 LEU A O 1 ATOM 628 C CB . LEU A 1 89 ? 36.874 -60.854 27.881 1.00 110.72 ? 120 LEU A CB 1 ATOM 629 C CG . LEU A 1 89 ? 35.485 -60.990 27.260 1.00 107.80 ? 120 LEU A CG 1 ATOM 630 C CD1 . LEU A 1 89 ? 34.490 -61.456 28.306 1.00 119.85 ? 120 LEU A CD1 1 ATOM 631 C CD2 . LEU A 1 89 ? 35.052 -59.683 26.598 1.00 97.75 ? 120 LEU A CD2 1 ATOM 632 N N . THR A 1 90 ? 40.374 -60.603 26.742 1.00 111.19 ? 121 THR A N 1 ATOM 633 C CA . THR A 1 90 ? 41.742 -60.409 27.190 1.00 102.18 ? 121 THR A CA 1 ATOM 634 C C . THR A 1 90 ? 42.366 -59.314 26.341 1.00 101.32 ? 121 THR A C 1 ATOM 635 O O . THR A 1 90 ? 42.168 -59.281 25.123 1.00 100.25 ? 121 THR A O 1 ATOM 636 C CB . THR A 1 90 ? 42.548 -61.706 27.030 1.00 100.60 ? 121 THR A CB 1 ATOM 637 O OG1 . THR A 1 90 ? 42.238 -62.598 28.104 1.00 108.07 ? 121 THR A OG1 1 ATOM 638 C CG2 . THR A 1 90 ? 44.018 -61.428 27.056 1.00 107.80 ? 121 THR A CG2 1 ATOM 639 N N . PRO A 1 91 ? 43.106 -58.400 26.984 1.00 102.80 ? 122 PRO A N 1 ATOM 640 C CA . PRO A 1 91 ? 43.803 -57.310 26.301 1.00 99.73 ? 122 PRO A CA 1 ATOM 641 C C . PRO A 1 91 ? 44.943 -57.860 25.462 1.00 102.75 ? 122 PRO A C 1 ATOM 642 O O . PRO A 1 91 ? 45.711 -58.712 25.913 1.00 102.92 ? 122 PRO A O 1 ATOM 643 C CB . PRO A 1 91 ? 44.387 -56.486 27.450 1.00 98.01 ? 122 PRO A CB 1 ATOM 644 C CG . PRO A 1 91 ? 43.703 -56.949 28.669 1.00 102.13 ? 122 PRO A CG 1 ATOM 645 C CD . PRO A 1 91 ? 43.363 -58.380 28.429 1.00 105.16 ? 122 PRO A CD 1 ATOM 646 N N . ILE A 1 92 ? 45.046 -57.376 24.237 1.00 99.78 ? 123 ILE A N 1 ATOM 647 C CA . ILE A 1 92 ? 46.114 -57.783 23.353 1.00 94.47 ? 123 ILE A CA 1 ATOM 648 C C . ILE A 1 92 ? 46.594 -56.513 22.713 1.00 94.92 ? 123 ILE A C 1 ATOM 649 O O . ILE A 1 92 ? 45.791 -55.770 22.151 1.00 97.17 ? 123 ILE A O 1 ATOM 650 C CB . ILE A 1 92 ? 45.602 -58.715 22.254 1.00 95.46 ? 123 ILE A CB 1 ATOM 651 C CG1 . ILE A 1 92 ? 45.308 -60.101 22.810 1.00 91.73 ? 123 ILE A CG1 1 ATOM 652 C CG2 . ILE A 1 92 ? 46.601 -58.821 21.124 1.00 93.59 ? 123 ILE A CG2 1 ATOM 653 C CD1 . ILE A 1 92 ? 44.685 -60.997 21.774 1.00 91.46 ? 123 ILE A CD1 1 ATOM 654 N N . LEU A 1 93 ? 47.895 -56.254 22.806 1.00 95.32 ? 124 LEU A N 1 ATOM 655 C CA . LEU A 1 93 ? 48.473 -55.039 22.249 1.00 89.59 ? 124 LEU A CA 1 ATOM 656 C C . LEU A 1 93 ? 49.236 -55.334 20.956 1.00 88.26 ? 124 LEU A C 1 ATOM 657 O O . LEU A 1 93 ? 50.094 -56.209 20.914 1.00 89.33 ? 124 LEU A O 1 ATOM 658 C CB . LEU A 1 93 ? 49.360 -54.366 23.294 1.00 88.70 ? 124 LEU A CB 1 ATOM 659 C CG . LEU A 1 93 ? 48.683 -54.243 24.659 1.00 85.73 ? 124 LEU A CG 1 ATOM 660 C CD1 . LEU A 1 93 ? 49.427 -53.311 25.572 1.00 85.79 ? 124 LEU A CD1 1 ATOM 661 C CD2 . LEU A 1 93 ? 47.290 -53.733 24.453 1.00 93.20 ? 124 LEU A CD2 1 ATOM 662 N N . GLY A 1 94 ? 48.885 -54.618 19.894 1.00 90.25 ? 125 GLY A N 1 ATOM 663 C CA . GLY A 1 94 ? 49.528 -54.775 18.601 1.00 93.63 ? 125 GLY A CA 1 ATOM 664 C C . GLY A 1 94 ? 50.697 -53.820 18.518 1.00 96.89 ? 125 GLY A C 1 ATOM 665 O O . GLY A 1 94 ? 50.594 -52.687 18.040 1.00 97.25 ? 125 GLY A O 1 ATOM 666 N N . ILE A 1 95 ? 51.829 -54.309 18.992 1.00 97.89 ? 126 ILE A N 1 ATOM 667 C CA . ILE A 1 95 ? 52.967 -53.481 19.343 1.00 95.91 ? 126 ILE A CA 1 ATOM 668 C C . ILE A 1 95 ? 53.777 -53.021 18.136 1.00 94.75 ? 126 ILE A C 1 ATOM 669 O O . ILE A 1 95 ? 54.469 -52.021 18.212 1.00 91.56 ? 126 ILE A O 1 ATOM 670 C CB . ILE A 1 95 ? 53.892 -54.292 20.248 1.00 97.97 ? 126 ILE A CB 1 ATOM 671 C CG1 . ILE A 1 95 ? 54.167 -53.584 21.552 1.00 98.98 ? 126 ILE A CG1 1 ATOM 672 C CG2 . ILE A 1 95 ? 55.197 -54.628 19.557 1.00 96.35 ? 126 ILE A CG2 1 ATOM 673 C CD1 . ILE A 1 95 ? 55.325 -54.243 22.259 1.00 103.70 ? 126 ILE A CD1 1 ATOM 674 N N . HIS A 1 96 ? 53.688 -53.740 17.022 1.00 95.99 ? 127 HIS A N 1 ATOM 675 C CA . HIS A 1 96 ? 54.617 -53.527 15.923 1.00 96.45 ? 127 HIS A CA 1 ATOM 676 C C . HIS A 1 96 ? 54.356 -54.552 14.839 1.00 96.74 ? 127 HIS A C 1 ATOM 677 O O . HIS A 1 96 ? 54.097 -55.717 15.123 1.00 98.92 ? 127 HIS A O 1 ATOM 678 C CB . HIS A 1 96 ? 56.047 -53.679 16.462 1.00 104.17 ? 127 HIS A CB 1 ATOM 679 C CG . HIS A 1 96 ? 57.129 -53.620 15.422 1.00 106.27 ? 127 HIS A CG 1 ATOM 680 N ND1 . HIS A 1 96 ? 57.631 -54.745 14.807 1.00 99.54 ? 127 HIS A ND1 1 ATOM 681 C CD2 . HIS A 1 96 ? 57.843 -52.575 14.941 1.00 114.63 ? 127 HIS A CD2 1 ATOM 682 C CE1 . HIS A 1 96 ? 58.585 -54.392 13.960 1.00 107.64 ? 127 HIS A CE1 1 ATOM 683 N NE2 . HIS A 1 96 ? 58.750 -53.087 14.040 1.00 125.13 ? 127 HIS A NE2 1 ATOM 684 N N . GLY A 1 97 ? 54.423 -54.125 13.590 1.00 94.58 ? 128 GLY A N 1 ATOM 685 C CA . GLY A 1 97 ? 54.350 -55.067 12.498 1.00 97.23 ? 128 GLY A CA 1 ATOM 686 C C . GLY A 1 97 ? 52.989 -55.049 11.868 1.00 100.66 ? 128 GLY A C 1 ATOM 687 O O . GLY A 1 97 ? 52.283 -54.052 11.968 1.00 102.18 ? 128 GLY A O 1 ATOM 688 N N . GLY A 1 98 ? 52.623 -56.142 11.210 1.00 100.76 ? 129 GLY A N 1 ATOM 689 C CA . GLY A 1 98 ? 51.314 -56.238 10.606 1.00 99.88 ? 129 GLY A CA 1 ATOM 690 C C . GLY A 1 98 ? 50.294 -56.082 11.707 1.00 99.40 ? 129 GLY A C 1 ATOM 691 O O . GLY A 1 98 ? 49.242 -55.472 11.528 1.00 100.14 ? 129 GLY A O 1 ATOM 692 N N . SER A 1 99 ? 50.635 -56.617 12.869 1.00 93.43 ? 130 SER A N 1 ATOM 693 C CA . SER A 1 99 ? 49.740 -56.604 14.003 1.00 95.06 ? 130 SER A CA 1 ATOM 694 C C . SER A 1 99 ? 49.331 -55.193 14.424 1.00 94.39 ? 130 SER A C 1 ATOM 695 O O . SER A 1 99 ? 48.443 -55.029 15.247 1.00 97.00 ? 130 SER A O 1 ATOM 696 C CB . SER A 1 99 ? 50.380 -57.321 15.188 1.00 96.28 ? 130 SER A CB 1 ATOM 697 O OG . SER A 1 99 ? 50.976 -56.389 16.075 1.00 100.02 ? 130 SER A OG 1 ATOM 698 N N . SER A 1 100 ? 49.961 -54.165 13.881 1.00 93.45 ? 131 SER A N 1 ATOM 699 C CA . SER A 1 100 ? 49.638 -52.828 14.347 1.00 94.55 ? 131 SER A CA 1 ATOM 700 C C . SER A 1 100 ? 49.240 -51.902 13.207 1.00 96.94 ? 131 SER A C 1 ATOM 701 O O . SER A 1 100 ? 49.102 -50.692 13.393 1.00 101.98 ? 131 SER A O 1 ATOM 702 C CB . SER A 1 100 ? 50.808 -52.244 15.116 1.00 92.74 ? 131 SER A CB 1 ATOM 703 O OG . SER A 1 100 ? 51.731 -51.688 14.210 1.00 98.08 ? 131 SER A OG 1 ATOM 704 N N . MET A 1 101 ? 49.053 -52.475 12.027 1.00 95.09 ? 132 MET A N 1 ATOM 705 C CA . MET A 1 101 ? 48.565 -51.714 10.895 1.00 93.97 ? 132 MET A CA 1 ATOM 706 C C . MET A 1 101 ? 47.081 -51.402 11.084 1.00 101.79 ? 132 MET A C 1 ATOM 707 O O . MET A 1 101 ? 46.292 -52.277 11.450 1.00 103.63 ? 132 MET A O 1 ATOM 708 C CB . MET A 1 101 ? 48.819 -52.485 9.604 1.00 94.54 ? 132 MET A CB 1 ATOM 709 C CG . MET A 1 101 ? 50.291 -52.581 9.258 1.00 104.30 ? 132 MET A CG 1 ATOM 710 S SD . MET A 1 101 ? 50.779 -53.862 8.087 1.00 114.56 ? 132 MET A SD 1 ATOM 711 C CE . MET A 1 101 ? 50.111 -53.225 6.547 1.00 110.70 ? 132 MET A CE 1 ATOM 712 N N . ILE A 1 102 ? 46.706 -50.150 10.837 1.00 102.02 ? 133 ILE A N 1 ATOM 713 C CA . ILE A 1 102 ? 45.346 -49.675 11.089 1.00 97.77 ? 133 ILE A CA 1 ATOM 714 C C . ILE A 1 102 ? 44.281 -50.697 10.763 1.00 101.15 ? 133 ILE A C 1 ATOM 715 O O . ILE A 1 102 ? 44.086 -51.062 9.605 1.00 102.24 ? 133 ILE A O 1 ATOM 716 C CB . ILE A 1 102 ? 45.019 -48.424 10.274 1.00 99.38 ? 133 ILE A CB 1 ATOM 717 C CG1 . ILE A 1 102 ? 45.534 -48.585 8.840 1.00 103.66 ? 133 ILE A CG1 1 ATOM 718 C CG2 . ILE A 1 102 ? 45.612 -47.199 10.942 1.00 108.81 ? 133 ILE A CG2 1 ATOM 719 C CD1 . ILE A 1 102 ? 44.980 -47.574 7.851 1.00 101.15 ? 133 ILE A CD1 1 ATOM 720 N N . MET A 1 103 ? 43.582 -51.146 11.796 1.00 105.10 ? 134 MET A N 1 ATOM 721 C CA . MET A 1 103 ? 42.418 -51.998 11.618 1.00 104.38 ? 134 MET A CA 1 ATOM 722 C C . MET A 1 103 ? 41.174 -51.161 11.798 1.00 101.89 ? 134 MET A C 1 ATOM 723 O O . MET A 1 103 ? 40.807 -50.826 12.923 1.00 97.90 ? 134 MET A O 1 ATOM 724 C CB . MET A 1 103 ? 42.418 -53.127 12.639 1.00 103.44 ? 134 MET A CB 1 ATOM 725 C CG . MET A 1 103 ? 41.300 -54.109 12.417 1.00 106.41 ? 134 MET A CG 1 ATOM 726 S SD . MET A 1 103 ? 41.446 -55.538 13.484 1.00 108.63 ? 134 MET A SD 1 ATOM 727 C CE . MET A 1 103 ? 40.064 -56.503 12.888 1.00 115.31 ? 134 MET A CE 1 ATOM 728 N N . ALA A 1 104 ? 40.531 -50.820 10.688 1.00 102.17 ? 135 ALA A N 1 ATOM 729 C CA . ALA A 1 104 ? 39.429 -49.863 10.718 1.00 109.51 ? 135 ALA A CA 1 ATOM 730 C C . ALA A 1 104 ? 38.242 -50.361 11.551 1.00 118.48 ? 135 ALA A C 1 ATOM 731 O O . ALA A 1 104 ? 37.967 -49.847 12.639 1.00 121.78 ? 135 ALA A O 1 ATOM 732 C CB . ALA A 1 104 ? 38.997 -49.516 9.305 1.00 105.24 ? 135 ALA A CB 1 ATOM 733 N N . ASP A 1 105 ? 37.532 -51.352 11.020 1.00 120.54 ? 136 ASP A N 1 ATOM 734 C CA . ASP A 1 105 ? 36.491 -52.055 11.762 1.00 122.98 ? 136 ASP A CA 1 ATOM 735 C C . ASP A 1 105 ? 37.151 -52.786 12.915 1.00 121.38 ? 136 ASP A C 1 ATOM 736 O O . ASP A 1 105 ? 38.252 -53.306 12.761 1.00 126.63 ? 136 ASP A O 1 ATOM 737 C CB . ASP A 1 105 ? 35.809 -53.091 10.858 1.00 138.65 ? 136 ASP A CB 1 ATOM 738 C CG . ASP A 1 105 ? 36.723 -54.303 10.529 1.00 144.25 ? 136 ASP A CG 1 ATOM 739 O OD1 . ASP A 1 105 ? 37.887 -54.106 10.075 1.00 128.94 ? 136 ASP A OD1 1 ATOM 740 O OD2 . ASP A 1 105 ? 36.263 -55.459 10.716 1.00 144.74 ? 136 ASP A OD2 1 ATOM 741 N N . LYS A 1 106 ? 36.495 -52.853 14.064 1.00 113.42 ? 137 LYS A N 1 ATOM 742 C CA . LYS A 1 106 ? 37.077 -53.590 15.175 1.00 113.98 ? 137 LYS A CA 1 ATOM 743 C C . LYS A 1 106 ? 35.994 -53.948 16.161 1.00 113.47 ? 137 LYS A C 1 ATOM 744 O O . LYS A 1 106 ? 35.222 -53.088 16.565 1.00 115.26 ? 137 LYS A O 1 ATOM 745 C CB . LYS A 1 106 ? 38.166 -52.761 15.866 1.00 112.72 ? 137 LYS A CB 1 ATOM 746 C CG . LYS A 1 106 ? 39.280 -53.591 16.505 1.00 106.13 ? 137 LYS A CG 1 ATOM 747 C CD . LYS A 1 106 ? 40.389 -52.714 17.109 1.00 106.43 ? 137 LYS A CD 1 ATOM 748 C CE . LYS A 1 106 ? 41.149 -51.921 16.050 1.00 103.02 ? 137 LYS A CE 1 ATOM 749 N NZ . LYS A 1 106 ? 42.240 -51.123 16.661 1.00 101.09 ? 137 LYS A NZ 1 ATOM 750 N N . ASP A 1 107 ? 35.943 -55.217 16.551 1.00 112.44 ? 138 ASP A N 1 ATOM 751 C CA . ASP A 1 107 ? 34.926 -55.696 17.479 1.00 113.31 ? 138 ASP A CA 1 ATOM 752 C C . ASP A 1 107 ? 34.834 -54.819 18.726 1.00 116.65 ? 138 ASP A C 1 ATOM 753 O O . ASP A 1 107 ? 35.726 -54.839 19.569 1.00 120.19 ? 138 ASP A O 1 ATOM 754 C CB . ASP A 1 107 ? 35.215 -57.138 17.873 1.00 114.13 ? 138 ASP A CB 1 ATOM 755 C CG . ASP A 1 107 ? 34.011 -57.822 18.480 1.00 125.40 ? 138 ASP A CG 1 ATOM 756 O OD1 . ASP A 1 107 ? 33.079 -57.111 18.931 1.00 121.01 ? 138 ASP A OD1 1 ATOM 757 O OD2 . ASP A 1 107 ? 34.000 -59.075 18.500 1.00 132.29 ? 138 ASP A OD2 1 ATOM 758 N N . GLU A 1 108 ? 33.745 -54.061 18.841 1.00 117.38 ? 139 GLU A N 1 ATOM 759 C CA . GLU A 1 108 ? 33.607 -53.061 19.902 1.00 118.31 ? 139 GLU A CA 1 ATOM 760 C C . GLU A 1 108 ? 33.590 -53.682 21.298 1.00 121.44 ? 139 GLU A C 1 ATOM 761 O O . GLU A 1 108 ? 33.492 -52.974 22.304 1.00 126.59 ? 139 GLU A O 1 ATOM 762 C CB . GLU A 1 108 ? 32.364 -52.187 19.681 1.00 111.25 ? 139 GLU A CB 1 ATOM 763 N N . SER A 1 109 ? 33.689 -55.005 21.355 1.00 116.72 ? 140 SER A N 1 ATOM 764 C CA . SER A 1 109 ? 33.721 -55.707 22.627 1.00 118.27 ? 140 SER A CA 1 ATOM 765 C C . SER A 1 109 ? 35.145 -56.138 22.964 1.00 119.78 ? 140 SER A C 1 ATOM 766 O O . SER A 1 109 ? 35.450 -56.473 24.111 1.00 118.60 ? 140 SER A O 1 ATOM 767 C CB . SER A 1 109 ? 32.826 -56.936 22.565 1.00 121.30 ? 140 SER A CB 1 ATOM 768 O OG . SER A 1 109 ? 33.485 -57.986 21.879 1.00 121.05 ? 140 SER A OG 1 ATOM 769 N N . SER A 1 110 ? 36.011 -56.129 21.953 1.00 119.09 ? 141 SER A N 1 ATOM 770 C CA . SER A 1 110 ? 37.388 -56.591 22.108 1.00 111.74 ? 141 SER A CA 1 ATOM 771 C C . SER A 1 110 ? 38.266 -55.557 22.779 1.00 112.40 ? 141 SER A C 1 ATOM 772 O O . SER A 1 110 ? 37.949 -54.357 22.808 1.00 113.89 ? 141 SER A O 1 ATOM 773 C CB . SER A 1 110 ? 38.010 -56.922 20.756 1.00 107.65 ? 141 SER A CB 1 ATOM 774 O OG . SER A 1 110 ? 38.607 -55.765 20.194 1.00 103.00 ? 141 SER A OG 1 ATOM 775 N N . MET A 1 111 ? 39.389 -56.043 23.295 1.00 104.74 ? 142 MET A N 1 ATOM 776 C CA . MET A 1 111 ? 40.379 -55.189 23.923 1.00 108.09 ? 142 MET A CA 1 ATOM 777 C C . MET A 1 111 ? 41.698 -55.273 23.153 1.00 105.44 ? 142 MET A C 1 ATOM 778 O O . MET A 1 111 ? 42.783 -55.415 23.723 1.00 102.93 ? 142 MET A O 1 ATOM 779 C CB . MET A 1 111 ? 40.542 -55.581 25.383 1.00 107.39 ? 142 MET A CB 1 ATOM 780 C CG . MET A 1 111 ? 39.216 -55.759 26.067 1.00 109.45 ? 142 MET A CG 1 ATOM 781 S SD . MET A 1 111 ? 39.373 -56.352 27.749 1.00 126.01 ? 142 MET A SD 1 ATOM 782 C CE . MET A 1 111 ? 39.900 -54.849 28.564 1.00 109.73 ? 142 MET A CE 1 ATOM 783 N N . PHE A 1 112 ? 41.574 -55.184 21.837 1.00 101.17 ? 143 PHE A N 1 ATOM 784 C CA . PHE A 1 112 ? 42.711 -55.167 20.951 1.00 94.44 ? 143 PHE A CA 1 ATOM 785 C C . PHE A 1 112 ? 43.103 -53.728 20.682 1.00 99.72 ? 143 PHE A C 1 ATOM 786 O O . PHE A 1 112 ? 42.362 -52.980 20.031 1.00 99.92 ? 143 PHE A O 1 ATOM 787 C CB . PHE A 1 112 ? 42.343 -55.853 19.645 1.00 94.87 ? 143 PHE A CB 1 ATOM 788 C CG . PHE A 1 112 ? 43.435 -55.838 18.631 1.00 95.67 ? 143 PHE A CG 1 ATOM 789 C CD1 . PHE A 1 112 ? 44.715 -56.239 18.969 1.00 94.31 ? 143 PHE A CD1 1 ATOM 790 C CD2 . PHE A 1 112 ? 43.185 -55.440 17.332 1.00 97.53 ? 143 PHE A CD2 1 ATOM 791 C CE1 . PHE A 1 112 ? 45.730 -56.236 18.031 1.00 93.01 ? 143 PHE A CE1 1 ATOM 792 C CE2 . PHE A 1 112 ? 44.200 -55.438 16.384 1.00 100.47 ? 143 PHE A CE2 1 ATOM 793 C CZ . PHE A 1 112 ? 45.475 -55.835 16.737 1.00 94.84 ? 143 PHE A CZ 1 ATOM 794 N N . PHE A 1 113 ? 44.268 -53.338 21.194 1.00 100.48 ? 144 PHE A N 1 ATOM 795 C CA . PHE A 1 113 ? 44.805 -51.999 20.972 1.00 96.21 ? 144 PHE A CA 1 ATOM 796 C C . PHE A 1 113 ? 46.078 -52.061 20.138 1.00 96.81 ? 144 PHE A C 1 ATOM 797 O O . PHE A 1 113 ? 46.880 -52.984 20.279 1.00 91.60 ? 144 PHE A O 1 ATOM 798 C CB . PHE A 1 113 ? 45.089 -51.324 22.303 1.00 95.29 ? 144 PHE A CB 1 ATOM 799 C CG . PHE A 1 113 ? 43.924 -51.331 23.241 1.00 99.83 ? 144 PHE A CG 1 ATOM 800 C CD1 . PHE A 1 113 ? 42.902 -50.407 23.101 1.00 102.18 ? 144 PHE A CD1 1 ATOM 801 C CD2 . PHE A 1 113 ? 43.849 -52.254 24.269 1.00 100.64 ? 144 PHE A CD2 1 ATOM 802 C CE1 . PHE A 1 113 ? 41.826 -50.404 23.966 1.00 101.79 ? 144 PHE A CE1 1 ATOM 803 C CE2 . PHE A 1 113 ? 42.775 -52.253 25.142 1.00 101.00 ? 144 PHE A CE2 1 ATOM 804 C CZ . PHE A 1 113 ? 41.763 -51.325 24.987 1.00 103.62 ? 144 PHE A CZ 1 ATOM 805 N N . GLN A 1 114 ? 46.261 -51.076 19.268 1.00 93.02 ? 145 GLN A N 1 ATOM 806 C CA . GLN A 1 114 ? 47.407 -51.065 18.382 1.00 93.10 ? 145 GLN A CA 1 ATOM 807 C C . GLN A 1 114 ? 48.280 -49.857 18.627 1.00 100.63 ? 145 GLN A C 1 ATOM 808 O O . GLN A 1 114 ? 47.784 -48.771 18.903 1.00 100.69 ? 145 GLN A O 1 ATOM 809 C CB . GLN A 1 114 ? 46.948 -51.035 16.937 1.00 95.03 ? 145 GLN A CB 1 ATOM 810 C CG . GLN A 1 114 ? 46.338 -52.314 16.457 1.00 90.45 ? 145 GLN A CG 1 ATOM 811 C CD . GLN A 1 114 ? 45.767 -52.164 15.071 1.00 93.54 ? 145 GLN A CD 1 ATOM 812 O OE1 . GLN A 1 114 ? 44.961 -51.278 14.818 1.00 96.36 ? 145 GLN A OE1 1 ATOM 813 N NE2 . GLN A 1 114 ? 46.184 -53.027 14.162 1.00 97.49 ? 145 GLN A NE2 1 ATOM 814 N N . PHE A 1 115 ? 49.589 -50.040 18.507 1.00 104.32 ? 146 PHE A N 1 ATOM 815 C CA . PHE A 1 115 ? 50.489 -48.901 18.550 1.00 102.81 ? 146 PHE A CA 1 ATOM 816 C C . PHE A 1 115 ? 50.457 -48.133 17.239 1.00 107.98 ? 146 PHE A C 1 ATOM 817 O O . PHE A 1 115 ? 50.163 -48.687 16.177 1.00 112.68 ? 146 PHE A O 1 ATOM 818 C CB . PHE A 1 115 ? 51.913 -49.323 18.877 1.00 101.27 ? 146 PHE A CB 1 ATOM 819 C CG . PHE A 1 115 ? 52.139 -49.601 20.330 1.00 104.72 ? 146 PHE A CG 1 ATOM 820 C CD1 . PHE A 1 115 ? 53.314 -50.183 20.765 1.00 108.41 ? 146 PHE A CD1 1 ATOM 821 C CD2 . PHE A 1 115 ? 51.172 -49.301 21.263 1.00 107.46 ? 146 PHE A CD2 1 ATOM 822 C CE1 . PHE A 1 115 ? 53.524 -50.446 22.109 1.00 107.35 ? 146 PHE A CE1 1 ATOM 823 C CE2 . PHE A 1 115 ? 51.377 -49.567 22.608 1.00 109.63 ? 146 PHE A CE2 1 ATOM 824 C CZ . PHE A 1 115 ? 52.554 -50.143 23.029 1.00 106.86 ? 146 PHE A CZ 1 ATOM 825 N N . GLY A 1 116 ? 50.756 -46.844 17.326 1.00 111.43 ? 147 GLY A N 1 ATOM 826 C CA . GLY A 1 116 ? 50.773 -45.990 16.158 1.00 112.71 ? 147 GLY A CA 1 ATOM 827 C C . GLY A 1 116 ? 49.427 -45.358 15.875 1.00 109.73 ? 147 GLY A C 1 ATOM 828 O O . GLY A 1 116 ? 48.443 -45.648 16.554 1.00 111.70 ? 147 GLY A O 1 ATOM 829 N N . PRO A 1 117 ? 49.377 -44.532 14.826 1.00 104.32 ? 148 PRO A N 1 ATOM 830 C CA . PRO A 1 117 ? 48.331 -43.565 14.493 1.00 102.74 ? 148 PRO A CA 1 ATOM 831 C C . PRO A 1 117 ? 47.063 -44.198 13.963 1.00 106.24 ? 148 PRO A C 1 ATOM 832 O O . PRO A 1 117 ? 47.102 -45.262 13.328 1.00 109.64 ? 148 PRO A O 1 ATOM 833 C CB . PRO A 1 117 ? 48.962 -42.751 13.360 1.00 102.07 ? 148 PRO A CB 1 ATOM 834 C CG . PRO A 1 117 ? 50.366 -43.281 13.198 1.00 103.98 ? 148 PRO A CG 1 ATOM 835 C CD . PRO A 1 117 ? 50.352 -44.648 13.738 1.00 106.17 ? 148 PRO A CD 1 ATOM 836 N N . SER A 1 118 ? 45.952 -43.511 14.212 1.00 100.97 ? 149 SER A N 1 ATOM 837 C CA . SER A 1 118 ? 44.646 -43.883 13.695 1.00 102.03 ? 149 SER A CA 1 ATOM 838 C C . SER A 1 118 ? 44.509 -43.467 12.237 1.00 104.49 ? 149 SER A C 1 ATOM 839 O O . SER A 1 118 ? 45.306 -42.673 11.744 1.00 105.09 ? 149 SER A O 1 ATOM 840 C CB . SER A 1 118 ? 43.585 -43.153 14.500 1.00 107.73 ? 149 SER A CB 1 ATOM 841 O OG . SER A 1 118 ? 43.877 -41.766 14.542 1.00 106.76 ? 149 SER A OG 1 ATOM 842 N N . ILE A 1 119 ? 43.490 -43.979 11.549 1.00 107.64 ? 150 ILE A N 1 ATOM 843 C CA . ILE A 1 119 ? 43.225 -43.530 10.181 1.00 105.29 ? 150 ILE A CA 1 ATOM 844 C C . ILE A 1 119 ? 43.065 -42.005 10.173 1.00 104.94 ? 150 ILE A C 1 ATOM 845 O O . ILE A 1 119 ? 43.521 -41.322 9.258 1.00 101.10 ? 150 ILE A O 1 ATOM 846 C CB . ILE A 1 119 ? 41.990 -44.227 9.541 1.00 83.26 ? 150 ILE A CB 1 ATOM 847 N N . GLU A 1 120 ? 42.446 -41.467 11.219 1.00 108.69 ? 151 GLU A N 1 ATOM 848 C CA . GLU A 1 120 ? 42.208 -40.032 11.278 1.00 105.06 ? 151 GLU A CA 1 ATOM 849 C C . GLU A 1 120 ? 43.501 -39.275 11.507 1.00 106.26 ? 151 GLU A C 1 ATOM 850 O O . GLU A 1 120 ? 43.802 -38.360 10.746 1.00 111.24 ? 151 GLU A O 1 ATOM 851 C CB . GLU A 1 120 ? 41.172 -39.664 12.345 1.00 104.47 ? 151 GLU A CB 1 ATOM 852 N N . GLN A 1 121 ? 44.264 -39.636 12.543 1.00 105.42 ? 152 GLN A N 1 ATOM 853 C CA . GLN A 1 121 ? 45.500 -38.902 12.839 1.00 100.41 ? 152 GLN A CA 1 ATOM 854 C C . GLN A 1 121 ? 46.337 -38.836 11.577 1.00 97.51 ? 152 GLN A C 1 ATOM 855 O O . GLN A 1 121 ? 46.787 -37.771 11.190 1.00 94.47 ? 152 GLN A O 1 ATOM 856 C CB . GLN A 1 121 ? 46.291 -39.507 14.011 1.00 91.25 ? 152 GLN A CB 1 ATOM 857 N N . GLN A 1 122 ? 46.502 -39.972 10.909 1.00 101.68 ? 153 GLN A N 1 ATOM 858 C CA . GLN A 1 122 ? 47.289 -40.020 9.684 1.00 100.43 ? 153 GLN A CA 1 ATOM 859 C C . GLN A 1 122 ? 46.755 -39.082 8.603 1.00 102.29 ? 153 GLN A C 1 ATOM 860 O O . GLN A 1 122 ? 47.519 -38.356 7.982 1.00 107.07 ? 153 GLN A O 1 ATOM 861 C CB . GLN A 1 122 ? 47.384 -41.445 9.155 1.00 96.31 ? 153 GLN A CB 1 ATOM 862 C CG . GLN A 1 122 ? 48.222 -42.352 10.015 1.00 95.92 ? 153 GLN A CG 1 ATOM 863 C CD . GLN A 1 122 ? 48.426 -43.705 9.382 1.00 99.90 ? 153 GLN A CD 1 ATOM 864 O OE1 . GLN A 1 122 ? 48.680 -43.805 8.183 1.00 99.00 ? 153 GLN A OE1 1 ATOM 865 N NE2 . GLN A 1 122 ? 48.316 -44.759 10.182 1.00 103.02 ? 153 GLN A NE2 1 ATOM 866 N N . ALA A 1 123 ? 45.450 -39.098 8.368 1.00 103.22 ? 154 ALA A N 1 ATOM 867 C CA . ALA A 1 123 ? 44.855 -38.128 7.454 1.00 103.27 ? 154 ALA A CA 1 ATOM 868 C C . ALA A 1 123 ? 45.197 -36.703 7.899 1.00 105.74 ? 154 ALA A C 1 ATOM 869 O O . ALA A 1 123 ? 45.749 -35.915 7.133 1.00 106.92 ? 154 ALA A O 1 ATOM 870 C CB . ALA A 1 123 ? 43.349 -38.314 7.377 1.00 100.02 ? 154 ALA A CB 1 ATOM 871 N N . SER A 1 124 ? 44.877 -36.378 9.147 1.00 106.20 ? 155 SER A N 1 ATOM 872 C CA . SER A 1 124 ? 45.130 -35.044 9.679 1.00 101.22 ? 155 SER A CA 1 ATOM 873 C C . SER A 1 124 ? 46.583 -34.595 9.473 1.00 103.82 ? 155 SER A C 1 ATOM 874 O O . SER A 1 124 ? 46.852 -33.409 9.347 1.00 110.88 ? 155 SER A O 1 ATOM 875 C CB . SER A 1 124 ? 44.745 -34.980 11.162 1.00 96.93 ? 155 SER A CB 1 ATOM 876 N N . VAL A 1 125 ? 47.517 -35.540 9.436 1.00 104.88 ? 156 VAL A N 1 ATOM 877 C CA . VAL A 1 125 ? 48.929 -35.211 9.242 1.00 101.38 ? 156 VAL A CA 1 ATOM 878 C C . VAL A 1 125 ? 49.276 -35.018 7.768 1.00 99.98 ? 156 VAL A C 1 ATOM 879 O O . VAL A 1 125 ? 50.034 -34.130 7.409 1.00 98.52 ? 156 VAL A O 1 ATOM 880 C CB . VAL A 1 125 ? 49.847 -36.296 9.818 1.00 97.29 ? 156 VAL A CB 1 ATOM 881 C CG1 . VAL A 1 125 ? 51.235 -36.136 9.280 1.00 102.14 ? 156 VAL A CG1 1 ATOM 882 C CG2 . VAL A 1 125 ? 49.876 -36.224 11.318 1.00 103.31 ? 156 VAL A CG2 1 ATOM 883 N N . MET A 1 126 ? 48.731 -35.864 6.912 1.00 103.30 ? 157 MET A N 1 ATOM 884 C CA . MET A 1 126 ? 48.963 -35.720 5.487 1.00 103.09 ? 157 MET A CA 1 ATOM 885 C C . MET A 1 126 ? 48.499 -34.352 4.991 1.00 105.58 ? 157 MET A C 1 ATOM 886 O O . MET A 1 126 ? 49.042 -33.826 4.032 1.00 107.42 ? 157 MET A O 1 ATOM 887 C CB . MET A 1 126 ? 48.280 -36.848 4.713 1.00 99.74 ? 157 MET A CB 1 ATOM 888 C CG . MET A 1 126 ? 48.871 -38.207 5.011 1.00 106.07 ? 157 MET A CG 1 ATOM 889 S SD . MET A 1 126 ? 48.004 -39.561 4.200 1.00 119.12 ? 157 MET A SD 1 ATOM 890 C CE . MET A 1 126 ? 48.031 -38.970 2.512 1.00 112.00 ? 157 MET A CE 1 ATOM 891 N N . LEU A 1 127 ? 47.496 -33.772 5.640 1.00 104.51 ? 158 LEU A N 1 ATOM 892 C CA . LEU A 1 127 ? 47.073 -32.423 5.285 1.00 106.64 ? 158 LEU A CA 1 ATOM 893 C C . LEU A 1 127 ? 48.016 -31.405 5.926 1.00 110.09 ? 158 LEU A C 1 ATOM 894 O O . LEU A 1 127 ? 48.448 -30.443 5.291 1.00 109.10 ? 158 LEU A O 1 ATOM 895 C CB . LEU A 1 127 ? 45.626 -32.172 5.702 1.00 102.27 ? 158 LEU A CB 1 ATOM 896 C CG . LEU A 1 127 ? 44.586 -32.849 4.817 1.00 101.46 ? 158 LEU A CG 1 ATOM 897 C CD1 . LEU A 1 127 ? 43.255 -32.191 4.993 1.00 106.03 ? 158 LEU A CD1 1 ATOM 898 C CD2 . LEU A 1 127 ? 44.999 -32.776 3.373 1.00 105.88 ? 158 LEU A CD2 1 ATOM 899 N N . ASN A 1 128 ? 48.336 -31.641 7.192 1.00 110.76 ? 159 ASN A N 1 ATOM 900 C CA . ASN A 1 128 ? 49.330 -30.869 7.923 1.00 109.58 ? 159 ASN A CA 1 ATOM 901 C C . ASN A 1 128 ? 50.590 -30.648 7.088 1.00 111.39 ? 159 ASN A C 1 ATOM 902 O O . ASN A 1 128 ? 51.239 -29.611 7.192 1.00 115.03 ? 159 ASN A O 1 ATOM 903 C CB . ASN A 1 128 ? 49.697 -31.621 9.205 1.00 114.83 ? 159 ASN A CB 1 ATOM 904 C CG . ASN A 1 128 ? 49.795 -30.717 10.419 1.00 125.09 ? 159 ASN A CG 1 ATOM 905 O OD1 . ASN A 1 128 ? 48.924 -30.754 11.299 1.00 130.88 ? 159 ASN A OD1 1 ATOM 906 N ND2 . ASN A 1 128 ? 50.860 -29.912 10.487 1.00 117.53 ? 159 ASN A ND2 1 ATOM 907 N N . ILE A 1 129 ? 50.936 -31.637 6.268 1.00 111.15 ? 160 ILE A N 1 ATOM 908 C CA . ILE A 1 129 ? 52.118 -31.559 5.417 1.00 107.13 ? 160 ILE A CA 1 ATOM 909 C C . ILE A 1 129 ? 51.826 -30.782 4.158 1.00 108.24 ? 160 ILE A C 1 ATOM 910 O O . ILE A 1 129 ? 52.577 -29.892 3.795 1.00 113.53 ? 160 ILE A O 1 ATOM 911 C CB . ILE A 1 129 ? 52.603 -32.942 4.970 1.00 106.04 ? 160 ILE A CB 1 ATOM 912 C CG1 . ILE A 1 129 ? 53.285 -33.670 6.127 1.00 108.52 ? 160 ILE A CG1 1 ATOM 913 C CG2 . ILE A 1 129 ? 53.550 -32.806 3.788 1.00 98.56 ? 160 ILE A CG2 1 ATOM 914 C CD1 . ILE A 1 129 ? 53.783 -35.052 5.776 1.00 96.49 ? 160 ILE A CD1 1 ATOM 915 N N . MET A 1 130 ? 50.740 -31.124 3.479 1.00 105.81 ? 161 MET A N 1 ATOM 916 C CA . MET A 1 130 ? 50.429 -30.469 2.220 1.00 109.13 ? 161 MET A CA 1 ATOM 917 C C . MET A 1 130 ? 50.356 -28.943 2.362 1.00 115.93 ? 161 MET A C 1 ATOM 918 O O . MET A 1 130 ? 50.516 -28.229 1.378 1.00 116.83 ? 161 MET A O 1 ATOM 919 C CB . MET A 1 130 ? 49.140 -31.027 1.609 1.00 110.21 ? 161 MET A CB 1 ATOM 920 C CG . MET A 1 130 ? 49.014 -32.535 1.703 1.00 107.75 ? 161 MET A CG 1 ATOM 921 S SD . MET A 1 130 ? 47.957 -33.320 0.464 1.00 115.91 ? 161 MET A SD 1 ATOM 922 C CE . MET A 1 130 ? 46.523 -32.261 0.431 1.00 117.15 ? 161 MET A CE 1 ATOM 923 N N . GLU A 1 131 ? 50.121 -28.446 3.578 1.00 114.96 ? 162 GLU A N 1 ATOM 924 C CA . GLU A 1 131 ? 50.097 -27.002 3.816 1.00 117.58 ? 162 GLU A CA 1 ATOM 925 C C . GLU A 1 131 ? 51.516 -26.440 3.881 1.00 119.51 ? 162 GLU A C 1 ATOM 926 O O . GLU A 1 131 ? 51.851 -25.483 3.184 1.00 123.10 ? 162 GLU A O 1 ATOM 927 C CB . GLU A 1 131 ? 49.337 -26.654 5.105 1.00 121.09 ? 162 GLU A CB 1 ATOM 928 C CG . GLU A 1 131 ? 48.782 -25.196 5.180 1.00 134.99 ? 162 GLU A CG 1 ATOM 929 C CD . GLU A 1 131 ? 49.839 -24.090 5.473 1.00 137.72 ? 162 GLU A CD 1 ATOM 930 O OE1 . GLU A 1 131 ? 50.741 -24.291 6.319 1.00 139.70 ? 162 GLU A OE1 1 ATOM 931 O OE2 . GLU A 1 131 ? 49.745 -22.994 4.869 1.00 131.70 ? 162 GLU A OE2 1 ATOM 932 N N . GLU A 1 132 ? 52.352 -27.029 4.723 1.00 112.77 ? 163 GLU A N 1 ATOM 933 C CA . GLU A 1 132 ? 53.713 -26.541 4.878 1.00 114.01 ? 163 GLU A CA 1 ATOM 934 C C . GLU A 1 132 ? 54.387 -26.282 3.535 1.00 114.92 ? 163 GLU A C 1 ATOM 935 O O . GLU A 1 132 ? 55.385 -25.572 3.469 1.00 119.42 ? 163 GLU A O 1 ATOM 936 C CB . GLU A 1 132 ? 54.555 -27.515 5.701 1.00 117.97 ? 163 GLU A CB 1 ATOM 937 C CG . GLU A 1 132 ? 54.223 -27.516 7.171 1.00 123.37 ? 163 GLU A CG 1 ATOM 938 C CD . GLU A 1 132 ? 54.641 -26.237 7.853 1.00 131.37 ? 163 GLU A CD 1 ATOM 939 O OE1 . GLU A 1 132 ? 55.820 -26.154 8.269 1.00 132.97 ? 163 GLU A OE1 1 ATOM 940 O OE2 . GLU A 1 132 ? 53.790 -25.321 7.975 1.00 137.02 ? 163 GLU A OE2 1 ATOM 941 N N . TYR A 1 133 ? 53.858 -26.862 2.466 1.00 111.03 ? 164 TYR A N 1 ATOM 942 C CA . TYR A 1 133 ? 54.440 -26.655 1.147 1.00 111.15 ? 164 TYR A CA 1 ATOM 943 C C . TYR A 1 133 ? 53.384 -26.150 0.185 1.00 114.82 ? 164 TYR A C 1 ATOM 944 O O . TYR A 1 133 ? 53.534 -26.242 -1.030 1.00 115.51 ? 164 TYR A O 1 ATOM 945 C CB . TYR A 1 133 ? 55.113 -27.931 0.635 1.00 105.34 ? 164 TYR A CB 1 ATOM 946 C CG . TYR A 1 133 ? 56.282 -28.346 1.495 1.00 104.91 ? 164 TYR A CG 1 ATOM 947 C CD1 . TYR A 1 133 ? 57.584 -28.124 1.089 1.00 108.58 ? 164 TYR A CD1 1 ATOM 948 C CD2 . TYR A 1 133 ? 56.079 -28.930 2.729 1.00 104.62 ? 164 TYR A CD2 1 ATOM 949 C CE1 . TYR A 1 133 ? 58.646 -28.488 1.886 1.00 108.02 ? 164 TYR A CE1 1 ATOM 950 C CE2 . TYR A 1 133 ? 57.128 -29.295 3.527 1.00 102.28 ? 164 TYR A CE2 1 ATOM 951 C CZ . TYR A 1 133 ? 58.408 -29.075 3.104 1.00 104.17 ? 164 TYR A CZ 1 ATOM 952 O OH . TYR A 1 133 ? 59.456 -29.441 3.909 1.00 106.41 ? 164 TYR A OH 1 ATOM 953 N N . ASP A 1 134 ? 52.315 -25.604 0.752 1.00 118.86 ? 165 ASP A N 1 ATOM 954 C CA . ASP A 1 134 ? 51.219 -25.030 -0.018 1.00 119.25 ? 165 ASP A CA 1 ATOM 955 C C . ASP A 1 134 ? 50.818 -25.903 -1.209 1.00 119.46 ? 165 ASP A C 1 ATOM 956 O O . ASP A 1 134 ? 50.617 -25.405 -2.320 1.00 116.83 ? 165 ASP A O 1 ATOM 957 C CB . ASP A 1 134 ? 51.567 -23.606 -0.466 1.00 127.91 ? 165 ASP A CB 1 ATOM 958 C CG . ASP A 1 134 ? 51.824 -22.657 0.712 1.00 134.03 ? 165 ASP A CG 1 ATOM 959 O OD1 . ASP A 1 134 ? 51.789 -23.108 1.883 1.00 129.46 ? 165 ASP A OD1 1 ATOM 960 O OD2 . ASP A 1 134 ? 52.062 -21.451 0.458 1.00 135.77 ? 165 ASP A OD2 1 ATOM 961 N N . TRP A 1 135 ? 50.716 -27.208 -0.950 1.00 121.27 ? 166 TRP A N 1 ATOM 962 C CA . TRP A 1 135 ? 50.233 -28.209 -1.905 1.00 117.39 ? 166 TRP A CA 1 ATOM 963 C C . TRP A 1 135 ? 48.717 -28.389 -1.774 1.00 120.62 ? 166 TRP A C 1 ATOM 964 O O . TRP A 1 135 ? 48.263 -29.379 -1.210 1.00 121.19 ? 166 TRP A O 1 ATOM 965 C CB . TRP A 1 135 ? 50.883 -29.562 -1.614 1.00 112.26 ? 166 TRP A CB 1 ATOM 966 C CG . TRP A 1 135 ? 52.279 -29.744 -2.124 1.00 115.33 ? 166 TRP A CG 1 ATOM 967 C CD1 . TRP A 1 135 ? 52.815 -29.217 -3.259 1.00 116.57 ? 166 TRP A CD1 1 ATOM 968 C CD2 . TRP A 1 135 ? 53.304 -30.560 -1.538 1.00 112.41 ? 166 TRP A CD2 1 ATOM 969 N NE1 . TRP A 1 135 ? 54.119 -29.630 -3.402 1.00 117.06 ? 166 TRP A NE1 1 ATOM 970 C CE2 . TRP A 1 135 ? 54.440 -30.457 -2.358 1.00 112.36 ? 166 TRP A CE2 1 ATOM 971 C CE3 . TRP A 1 135 ? 53.375 -31.354 -0.391 1.00 110.64 ? 166 TRP A CE3 1 ATOM 972 C CZ2 . TRP A 1 135 ? 55.629 -31.119 -2.068 1.00 114.27 ? 166 TRP A CZ2 1 ATOM 973 C CZ3 . TRP A 1 135 ? 54.558 -32.009 -0.106 1.00 108.00 ? 166 TRP A CZ3 1 ATOM 974 C CH2 . TRP A 1 135 ? 55.667 -31.888 -0.940 1.00 109.89 ? 166 TRP A CH2 1 ATOM 975 N N . TYR A 1 136 ? 47.933 -27.451 -2.298 1.00 121.76 ? 167 TYR A N 1 ATOM 976 C CA . TYR A 1 136 ? 46.511 -27.386 -1.963 1.00 118.99 ? 167 TYR A CA 1 ATOM 977 C C . TYR A 1 136 ? 45.572 -28.091 -2.949 1.00 118.77 ? 167 TYR A C 1 ATOM 978 O O . TYR A 1 136 ? 44.415 -28.357 -2.616 1.00 119.32 ? 167 TYR A O 1 ATOM 979 C CB . TYR A 1 136 ? 46.066 -25.929 -1.785 1.00 123.95 ? 167 TYR A CB 1 ATOM 980 C CG . TYR A 1 136 ? 46.866 -25.109 -0.782 1.00 125.86 ? 167 TYR A CG 1 ATOM 981 C CD1 . TYR A 1 136 ? 47.007 -25.522 0.538 1.00 129.13 ? 167 TYR A CD1 1 ATOM 982 C CD2 . TYR A 1 136 ? 47.451 -23.902 -1.152 1.00 127.81 ? 167 TYR A CD2 1 ATOM 983 C CE1 . TYR A 1 136 ? 47.727 -24.763 1.460 1.00 128.48 ? 167 TYR A CE1 1 ATOM 984 C CE2 . TYR A 1 136 ? 48.169 -23.136 -0.237 1.00 127.92 ? 167 TYR A CE2 1 ATOM 985 C CZ . TYR A 1 136 ? 48.302 -23.571 1.066 1.00 127.52 ? 167 TYR A CZ 1 ATOM 986 O OH . TYR A 1 136 ? 49.015 -22.814 1.975 1.00 128.80 ? 167 TYR A OH 1 ATOM 987 N N . ILE A 1 137 ? 46.052 -28.375 -4.159 1.00 117.09 ? 168 ILE A N 1 ATOM 988 C CA . ILE A 1 137 ? 45.230 -29.077 -5.151 1.00 120.30 ? 168 ILE A CA 1 ATOM 989 C C . ILE A 1 137 ? 45.638 -30.551 -5.245 1.00 125.96 ? 168 ILE A C 1 ATOM 990 O O . ILE A 1 137 ? 46.774 -30.868 -5.604 1.00 122.63 ? 168 ILE A O 1 ATOM 991 C CB . ILE A 1 137 ? 45.293 -28.413 -6.547 1.00 110.99 ? 168 ILE A CB 1 ATOM 992 N N . PHE A 1 138 ? 44.704 -31.447 -4.917 1.00 128.71 ? 169 PHE A N 1 ATOM 993 C CA . PHE A 1 138 ? 45.017 -32.871 -4.774 1.00 124.88 ? 169 PHE A CA 1 ATOM 994 C C . PHE A 1 138 ? 43.818 -33.774 -5.037 1.00 122.19 ? 169 PHE A C 1 ATOM 995 O O . PHE A 1 138 ? 42.672 -33.344 -4.938 1.00 122.00 ? 169 PHE A O 1 ATOM 996 C CB . PHE A 1 138 ? 45.540 -33.152 -3.365 1.00 122.21 ? 169 PHE A CB 1 ATOM 997 C CG . PHE A 1 138 ? 44.490 -33.031 -2.300 1.00 120.81 ? 169 PHE A CG 1 ATOM 998 C CD1 . PHE A 1 138 ? 44.020 -34.152 -1.643 1.00 123.88 ? 169 PHE A CD1 1 ATOM 999 C CD2 . PHE A 1 138 ? 43.959 -31.798 -1.970 1.00 119.90 ? 169 PHE A CD2 1 ATOM 1000 C CE1 . PHE A 1 138 ? 43.046 -34.041 -0.663 1.00 124.24 ? 169 PHE A CE1 1 ATOM 1001 C CE2 . PHE A 1 138 ? 42.990 -31.681 -0.996 1.00 120.01 ? 169 PHE A CE2 1 ATOM 1002 C CZ . PHE A 1 138 ? 42.533 -32.803 -0.340 1.00 119.33 ? 169 PHE A CZ 1 ATOM 1003 N N . SER A 1 139 ? 44.100 -35.031 -5.364 1.00 122.82 ? 170 SER A N 1 ATOM 1004 C CA . SER A 1 139 ? 43.064 -36.038 -5.545 1.00 122.72 ? 170 SER A CA 1 ATOM 1005 C C . SER A 1 139 ? 43.243 -37.111 -4.484 1.00 122.08 ? 170 SER A C 1 ATOM 1006 O O . SER A 1 139 ? 44.349 -37.303 -3.970 1.00 121.21 ? 170 SER A O 1 ATOM 1007 C CB . SER A 1 139 ? 43.159 -36.673 -6.937 1.00 122.95 ? 170 SER A CB 1 ATOM 1008 O OG . SER A 1 139 ? 42.836 -35.746 -7.960 1.00 123.56 ? 170 SER A OG 1 ATOM 1009 N N . ILE A 1 140 ? 42.158 -37.803 -4.148 1.00 116.53 ? 171 ILE A N 1 ATOM 1010 C CA . ILE A 1 140 ? 42.260 -38.977 -3.293 1.00 113.95 ? 171 ILE A CA 1 ATOM 1011 C C . ILE A 1 140 ? 42.036 -40.219 -4.122 1.00 112.31 ? 171 ILE A C 1 ATOM 1012 O O . ILE A 1 140 ? 41.283 -40.198 -5.086 1.00 115.14 ? 171 ILE A O 1 ATOM 1013 C CB . ILE A 1 140 ? 41.229 -38.978 -2.166 1.00 112.86 ? 171 ILE A CB 1 ATOM 1014 C CG1 . ILE A 1 140 ? 41.340 -37.700 -1.340 1.00 114.03 ? 171 ILE A CG1 1 ATOM 1015 C CG2 . ILE A 1 140 ? 41.420 -40.208 -1.289 1.00 109.70 ? 171 ILE A CG2 1 ATOM 1016 C CD1 . ILE A 1 140 ? 40.339 -37.620 -0.214 1.00 110.74 ? 171 ILE A CD1 1 ATOM 1017 N N . VAL A 1 141 ? 42.697 -41.302 -3.743 1.00 110.81 ? 172 VAL A N 1 ATOM 1018 C CA . VAL A 1 141 ? 42.552 -42.571 -4.432 1.00 112.71 ? 172 VAL A CA 1 ATOM 1019 C C . VAL A 1 141 ? 42.638 -43.688 -3.415 1.00 114.37 ? 172 VAL A C 1 ATOM 1020 O O . VAL A 1 141 ? 43.729 -44.025 -2.954 1.00 112.27 ? 172 VAL A O 1 ATOM 1021 C CB . VAL A 1 141 ? 43.665 -42.782 -5.464 1.00 111.39 ? 172 VAL A CB 1 ATOM 1022 C CG1 . VAL A 1 141 ? 43.731 -44.239 -5.873 1.00 110.48 ? 172 VAL A CG1 1 ATOM 1023 C CG2 . VAL A 1 141 ? 43.439 -41.899 -6.672 1.00 117.89 ? 172 VAL A CG2 1 ATOM 1024 N N . THR A 1 142 ? 41.487 -44.250 -3.054 1.00 115.48 ? 173 THR A N 1 ATOM 1025 C CA . THR A 1 142 ? 41.433 -45.325 -2.072 1.00 110.12 ? 173 THR A CA 1 ATOM 1026 C C . THR A 1 142 ? 40.924 -46.576 -2.735 1.00 108.87 ? 173 THR A C 1 ATOM 1027 O O . THR A 1 142 ? 40.324 -46.520 -3.802 1.00 115.83 ? 173 THR A O 1 ATOM 1028 C CB . THR A 1 142 ? 40.476 -45.000 -0.913 1.00 110.93 ? 173 THR A CB 1 ATOM 1029 O OG1 . THR A 1 142 ? 39.123 -45.215 -1.333 1.00 111.55 ? 173 THR A OG1 1 ATOM 1030 C CG2 . THR A 1 142 ? 40.646 -43.553 -0.460 1.00 112.45 ? 173 THR A CG2 1 ATOM 1031 N N . THR A 1 143 ? 41.168 -47.711 -2.101 1.00 108.25 ? 174 THR A N 1 ATOM 1032 C CA . THR A 1 143 ? 40.538 -48.944 -2.526 1.00 114.27 ? 174 THR A CA 1 ATOM 1033 C C . THR A 1 143 ? 39.379 -49.234 -1.586 1.00 117.15 ? 174 THR A C 1 ATOM 1034 O O . THR A 1 143 ? 38.774 -48.320 -1.018 1.00 116.13 ? 174 THR A O 1 ATOM 1035 C CB . THR A 1 143 ? 41.510 -50.129 -2.501 1.00 114.31 ? 174 THR A CB 1 ATOM 1036 O OG1 . THR A 1 143 ? 41.892 -50.409 -1.148 1.00 110.51 ? 174 THR A OG1 1 ATOM 1037 C CG2 . THR A 1 143 ? 42.740 -49.823 -3.330 1.00 114.60 ? 174 THR A CG2 1 ATOM 1038 N N . TYR A 1 144 ? 39.076 -50.511 -1.411 1.00 120.62 ? 175 TYR A N 1 ATOM 1039 C CA . TYR A 1 144 ? 37.958 -50.895 -0.570 1.00 119.84 ? 175 TYR A CA 1 ATOM 1040 C C . TYR A 1 144 ? 38.416 -51.324 0.814 1.00 118.00 ? 175 TYR A C 1 ATOM 1041 O O . TYR A 1 144 ? 37.599 -51.533 1.709 1.00 117.15 ? 175 TYR A O 1 ATOM 1042 C CB . TYR A 1 144 ? 37.123 -51.977 -1.251 1.00 118.33 ? 175 TYR A CB 1 ATOM 1043 C CG . TYR A 1 144 ? 36.118 -51.406 -2.220 1.00 123.10 ? 175 TYR A CG 1 ATOM 1044 C CD1 . TYR A 1 144 ? 34.972 -50.767 -1.758 1.00 121.68 ? 175 TYR A CD1 1 ATOM 1045 C CD2 . TYR A 1 144 ? 36.318 -51.491 -3.592 1.00 126.12 ? 175 TYR A CD2 1 ATOM 1046 C CE1 . TYR A 1 144 ? 34.052 -50.236 -2.632 1.00 125.81 ? 175 TYR A CE1 1 ATOM 1047 C CE2 . TYR A 1 144 ? 35.402 -50.964 -4.479 1.00 128.36 ? 175 TYR A CE2 1 ATOM 1048 C CZ . TYR A 1 144 ? 34.270 -50.337 -3.992 1.00 132.70 ? 175 TYR A CZ 1 ATOM 1049 O OH . TYR A 1 144 ? 33.349 -49.803 -4.863 1.00 139.17 ? 175 TYR A OH 1 ATOM 1050 N N . PHE A 1 145 ? 39.728 -51.436 0.983 1.00 115.07 ? 176 PHE A N 1 ATOM 1051 C CA . PHE A 1 145 ? 40.307 -51.745 2.282 1.00 109.84 ? 176 PHE A CA 1 ATOM 1052 C C . PHE A 1 145 ? 39.629 -50.935 3.388 1.00 111.47 ? 176 PHE A C 1 ATOM 1053 O O . PHE A 1 145 ? 39.535 -49.701 3.310 1.00 105.36 ? 176 PHE A O 1 ATOM 1054 C CB . PHE A 1 145 ? 41.812 -51.486 2.263 1.00 108.30 ? 176 PHE A CB 1 ATOM 1055 C CG . PHE A 1 145 ? 42.487 -51.696 3.590 1.00 106.20 ? 176 PHE A CG 1 ATOM 1056 C CD1 . PHE A 1 145 ? 42.975 -52.937 3.941 1.00 98.74 ? 176 PHE A CD1 1 ATOM 1057 C CD2 . PHE A 1 145 ? 42.655 -50.646 4.475 1.00 108.64 ? 176 PHE A CD2 1 ATOM 1058 C CE1 . PHE A 1 145 ? 43.609 -53.129 5.146 1.00 103.03 ? 176 PHE A CE1 1 ATOM 1059 C CE2 . PHE A 1 145 ? 43.287 -50.838 5.690 1.00 107.41 ? 176 PHE A CE2 1 ATOM 1060 C CZ . PHE A 1 145 ? 43.764 -52.079 6.021 1.00 107.86 ? 176 PHE A CZ 1 ATOM 1061 N N . PRO A 1 146 ? 39.144 -51.641 4.421 1.00 110.33 ? 177 PRO A N 1 ATOM 1062 C CA . PRO A 1 146 ? 38.445 -51.061 5.570 1.00 106.40 ? 177 PRO A CA 1 ATOM 1063 C C . PRO A 1 146 ? 39.138 -49.803 6.063 1.00 102.67 ? 177 PRO A C 1 ATOM 1064 O O . PRO A 1 146 ? 40.337 -49.801 6.309 1.00 107.87 ? 177 PRO A O 1 ATOM 1065 C CB . PRO A 1 146 ? 38.542 -52.164 6.625 1.00 106.25 ? 177 PRO A CB 1 ATOM 1066 C CG . PRO A 1 146 ? 38.601 -53.416 5.847 1.00 103.49 ? 177 PRO A CG 1 ATOM 1067 C CD . PRO A 1 146 ? 39.316 -53.098 4.559 1.00 104.66 ? 177 PRO A CD 1 ATOM 1068 N N . GLY A 1 147 ? 38.375 -48.738 6.212 1.00 98.76 ? 178 GLY A N 1 ATOM 1069 C CA . GLY A 1 147 ? 38.934 -47.474 6.623 1.00 102.33 ? 178 GLY A CA 1 ATOM 1070 C C . GLY A 1 147 ? 38.735 -46.446 5.533 1.00 109.36 ? 178 GLY A C 1 ATOM 1071 O O . GLY A 1 147 ? 38.514 -45.268 5.809 1.00 108.07 ? 178 GLY A O 1 ATOM 1072 N N . TYR A 1 148 ? 38.796 -46.891 4.282 1.00 111.32 ? 179 TYR A N 1 ATOM 1073 C CA . TYR A 1 148 ? 38.725 -45.952 3.171 1.00 110.87 ? 179 TYR A CA 1 ATOM 1074 C C . TYR A 1 148 ? 37.627 -44.932 3.425 1.00 106.01 ? 179 TYR A C 1 ATOM 1075 O O . TYR A 1 148 ? 37.863 -43.735 3.320 1.00 106.55 ? 179 TYR A O 1 ATOM 1076 C CB . TYR A 1 148 ? 38.549 -46.667 1.823 1.00 112.99 ? 179 TYR A CB 1 ATOM 1077 C CG . TYR A 1 148 ? 37.142 -47.092 1.516 1.00 113.36 ? 179 TYR A CG 1 ATOM 1078 C CD1 . TYR A 1 148 ? 36.282 -46.251 0.829 1.00 113.11 ? 179 TYR A CD1 1 ATOM 1079 C CD2 . TYR A 1 148 ? 36.673 -48.334 1.910 1.00 115.76 ? 179 TYR A CD2 1 ATOM 1080 C CE1 . TYR A 1 148 ? 34.985 -46.628 0.548 1.00 121.70 ? 179 TYR A CE1 1 ATOM 1081 C CE2 . TYR A 1 148 ? 35.377 -48.726 1.634 1.00 124.33 ? 179 TYR A CE2 1 ATOM 1082 C CZ . TYR A 1 148 ? 34.531 -47.868 0.951 1.00 127.52 ? 179 TYR A CZ 1 ATOM 1083 O OH . TYR A 1 148 ? 33.232 -48.245 0.667 1.00 125.03 ? 179 TYR A OH 1 ATOM 1084 N N . GLN A 1 149 ? 36.444 -45.400 3.806 1.00 109.06 ? 180 GLN A N 1 ATOM 1085 C CA . GLN A 1 149 ? 35.321 -44.496 4.045 1.00 114.12 ? 180 GLN A CA 1 ATOM 1086 C C . GLN A 1 149 ? 35.631 -43.499 5.164 1.00 111.87 ? 180 GLN A C 1 ATOM 1087 O O . GLN A 1 149 ? 35.389 -42.303 5.012 1.00 109.16 ? 180 GLN A O 1 ATOM 1088 C CB . GLN A 1 149 ? 34.029 -45.270 4.340 1.00 114.12 ? 180 GLN A CB 1 ATOM 1089 N N . ASP A 1 150 ? 36.174 -43.990 6.277 1.00 115.33 ? 181 ASP A N 1 ATOM 1090 C CA . ASP A 1 150 ? 36.489 -43.131 7.427 1.00 113.88 ? 181 ASP A CA 1 ATOM 1091 C C . ASP A 1 150 ? 37.598 -42.118 7.097 1.00 109.19 ? 181 ASP A C 1 ATOM 1092 O O . ASP A 1 150 ? 37.605 -40.995 7.604 1.00 105.75 ? 181 ASP A O 1 ATOM 1093 C CB . ASP A 1 150 ? 36.843 -43.979 8.668 1.00 95.33 ? 181 ASP A CB 1 ATOM 1094 N N . PHE A 1 151 ? 38.520 -42.530 6.231 1.00 109.69 ? 182 PHE A N 1 ATOM 1095 C CA . PHE A 1 151 ? 39.670 -41.722 5.824 1.00 106.74 ? 182 PHE A CA 1 ATOM 1096 C C . PHE A 1 151 ? 39.245 -40.558 4.943 1.00 108.77 ? 182 PHE A C 1 ATOM 1097 O O . PHE A 1 151 ? 39.534 -39.403 5.252 1.00 107.58 ? 182 PHE A O 1 ATOM 1098 C CB . PHE A 1 151 ? 40.671 -42.608 5.084 1.00 106.70 ? 182 PHE A CB 1 ATOM 1099 C CG . PHE A 1 151 ? 41.796 -41.865 4.428 1.00 107.38 ? 182 PHE A CG 1 ATOM 1100 C CD1 . PHE A 1 151 ? 42.889 -41.434 5.166 1.00 107.59 ? 182 PHE A CD1 1 ATOM 1101 C CD2 . PHE A 1 151 ? 41.786 -41.639 3.061 1.00 108.76 ? 182 PHE A CD2 1 ATOM 1102 C CE1 . PHE A 1 151 ? 43.939 -40.767 4.557 1.00 102.24 ? 182 PHE A CE1 1 ATOM 1103 C CE2 . PHE A 1 151 ? 42.837 -40.973 2.443 1.00 109.58 ? 182 PHE A CE2 1 ATOM 1104 C CZ . PHE A 1 151 ? 43.912 -40.538 3.193 1.00 103.39 ? 182 PHE A CZ 1 ATOM 1105 N N . VAL A 1 152 ? 38.547 -40.869 3.853 1.00 110.55 ? 183 VAL A N 1 ATOM 1106 C CA . VAL A 1 152 ? 38.023 -39.848 2.946 1.00 107.11 ? 183 VAL A CA 1 ATOM 1107 C C . VAL A 1 152 ? 37.202 -38.782 3.678 1.00 108.34 ? 183 VAL A C 1 ATOM 1108 O O . VAL A 1 152 ? 37.266 -37.599 3.348 1.00 111.66 ? 183 VAL A O 1 ATOM 1109 C CB . VAL A 1 152 ? 37.176 -40.470 1.826 1.00 97.21 ? 183 VAL A CB 1 ATOM 1110 C CG1 . VAL A 1 152 ? 36.630 -39.395 0.941 1.00 105.38 ? 183 VAL A CG1 1 ATOM 1111 C CG2 . VAL A 1 152 ? 38.010 -41.435 1.007 1.00 99.12 ? 183 VAL A CG2 1 ATOM 1112 N N . ASN A 1 153 ? 36.442 -39.204 4.681 1.00 108.38 ? 184 ASN A N 1 ATOM 1113 C CA . ASN A 1 153 ? 35.650 -38.276 5.481 1.00 110.95 ? 184 ASN A CA 1 ATOM 1114 C C . ASN A 1 153 ? 36.491 -37.282 6.262 1.00 112.91 ? 184 ASN A C 1 ATOM 1115 O O . ASN A 1 153 ? 36.139 -36.111 6.361 1.00 114.82 ? 184 ASN A O 1 ATOM 1116 C CB . ASN A 1 153 ? 34.757 -39.036 6.458 1.00 112.92 ? 184 ASN A CB 1 ATOM 1117 C CG . ASN A 1 153 ? 33.624 -39.756 5.769 1.00 119.89 ? 184 ASN A CG 1 ATOM 1118 O OD1 . ASN A 1 153 ? 33.280 -39.456 4.621 1.00 119.90 ? 184 ASN A OD1 1 ATOM 1119 N ND2 . ASN A 1 153 ? 33.030 -40.716 6.468 1.00 122.43 ? 184 ASN A ND2 1 ATOM 1120 N N . LYS A 1 154 ? 37.591 -37.760 6.834 1.00 111.13 ? 185 LYS A N 1 ATOM 1121 C CA . LYS A 1 154 ? 38.450 -36.915 7.648 1.00 110.47 ? 185 LYS A CA 1 ATOM 1122 C C . LYS A 1 154 ? 39.057 -35.820 6.793 1.00 116.89 ? 185 LYS A C 1 ATOM 1123 O O . LYS A 1 154 ? 39.274 -34.695 7.256 1.00 114.65 ? 185 LYS A O 1 ATOM 1124 C CB . LYS A 1 154 ? 39.556 -37.742 8.290 1.00 109.07 ? 185 LYS A CB 1 ATOM 1125 C CG . LYS A 1 154 ? 40.504 -36.925 9.138 1.00 107.60 ? 185 LYS A CG 1 ATOM 1126 C CD . LYS A 1 154 ? 39.736 -36.001 10.053 1.00 108.89 ? 185 LYS A CD 1 ATOM 1127 C CE . LYS A 1 154 ? 40.619 -35.499 11.175 1.00 115.65 ? 185 LYS A CE 1 ATOM 1128 N NZ . LYS A 1 154 ? 39.812 -34.892 12.267 1.00 122.65 ? 185 LYS A NZ 1 ATOM 1129 N N . ILE A 1 155 ? 39.335 -36.162 5.539 1.00 117.03 ? 186 ILE A N 1 ATOM 1130 C CA . ILE A 1 155 ? 39.844 -35.191 4.582 1.00 117.73 ? 186 ILE A CA 1 ATOM 1131 C C . ILE A 1 155 ? 38.747 -34.172 4.306 1.00 120.12 ? 186 ILE A C 1 ATOM 1132 O O . ILE A 1 155 ? 38.877 -32.995 4.652 1.00 121.48 ? 186 ILE A O 1 ATOM 1133 C CB . ILE A 1 155 ? 40.299 -35.862 3.259 1.00 117.05 ? 186 ILE A CB 1 ATOM 1134 C CG1 . ILE A 1 155 ? 41.424 -36.868 3.519 1.00 111.28 ? 186 ILE A CG1 1 ATOM 1135 C CG2 . ILE A 1 155 ? 40.769 -34.823 2.264 1.00 117.85 ? 186 ILE A CG2 1 ATOM 1136 C CD1 . ILE A 1 155 ? 42.573 -36.306 4.319 1.00 104.09 ? 186 ILE A CD1 1 ATOM 1137 N N . ARG A 1 156 ? 37.655 -34.635 3.705 1.00 119.11 ? 187 ARG A N 1 ATOM 1138 C CA . ARG A 1 156 ? 36.533 -33.763 3.381 1.00 120.03 ? 187 ARG A CA 1 ATOM 1139 C C . ARG A 1 156 ? 36.121 -32.874 4.548 1.00 120.47 ? 187 ARG A C 1 ATOM 1140 O O . ARG A 1 156 ? 35.840 -31.699 4.360 1.00 125.37 ? 187 ARG A O 1 ATOM 1141 C CB . ARG A 1 156 ? 35.337 -34.579 2.907 1.00 118.89 ? 187 ARG A CB 1 ATOM 1142 C CG . ARG A 1 156 ? 35.511 -35.160 1.531 1.00 119.62 ? 187 ARG A CG 1 ATOM 1143 C CD . ARG A 1 156 ? 34.201 -35.156 0.780 1.00 118.33 ? 187 ARG A CD 1 ATOM 1144 N NE . ARG A 1 156 ? 34.401 -35.498 -0.622 1.00 122.99 ? 187 ARG A NE 1 ATOM 1145 C CZ . ARG A 1 156 ? 34.141 -36.691 -1.144 1.00 124.92 ? 187 ARG A CZ 1 ATOM 1146 N NH1 . ARG A 1 156 ? 33.653 -37.662 -0.375 1.00 119.06 ? 187 ARG A NH1 1 ATOM 1147 N NH2 . ARG A 1 156 ? 34.362 -36.907 -2.438 1.00 122.63 ? 187 ARG A NH2 1 ATOM 1148 N N . SER A 1 157 ? 36.073 -33.442 5.746 1.00 117.42 ? 188 SER A N 1 ATOM 1149 C CA . SER A 1 157 ? 35.736 -32.679 6.938 1.00 119.34 ? 188 SER A CA 1 ATOM 1150 C C . SER A 1 157 ? 36.643 -31.466 7.122 1.00 127.69 ? 188 SER A C 1 ATOM 1151 O O . SER A 1 157 ? 36.183 -30.328 7.074 1.00 139.06 ? 188 SER A O 1 ATOM 1152 C CB . SER A 1 157 ? 35.812 -33.567 8.179 1.00 125.86 ? 188 SER A CB 1 ATOM 1153 O OG . SER A 1 157 ? 36.232 -32.823 9.311 1.00 130.13 ? 188 SER A OG 1 ATOM 1154 N N . THR A 1 158 ? 37.930 -31.708 7.342 1.00 128.42 ? 189 THR A N 1 ATOM 1155 C CA . THR A 1 158 ? 38.880 -30.624 7.596 1.00 131.80 ? 189 THR A CA 1 ATOM 1156 C C . THR A 1 158 ? 38.927 -29.594 6.460 1.00 131.61 ? 189 THR A C 1 ATOM 1157 O O . THR A 1 158 ? 39.162 -28.409 6.698 1.00 134.18 ? 189 THR A O 1 ATOM 1158 C CB . THR A 1 158 ? 40.295 -31.174 7.862 1.00 129.91 ? 189 THR A CB 1 ATOM 1159 O OG1 . THR A 1 158 ? 40.587 -32.200 6.909 1.00 130.78 ? 189 THR A OG1 1 ATOM 1160 C CG2 . THR A 1 158 ? 40.390 -31.764 9.268 1.00 125.48 ? 189 THR A CG2 1 ATOM 1161 N N . ILE A 1 159 ? 38.706 -30.053 5.231 1.00 127.14 ? 190 ILE A N 1 ATOM 1162 C CA . ILE A 1 159 ? 38.580 -29.165 4.078 1.00 128.93 ? 190 ILE A CA 1 ATOM 1163 C C . ILE A 1 159 ? 37.440 -28.137 4.214 1.00 140.00 ? 190 ILE A C 1 ATOM 1164 O O . ILE A 1 159 ? 37.671 -26.927 4.110 1.00 144.49 ? 190 ILE A O 1 ATOM 1165 C CB . ILE A 1 159 ? 38.342 -29.972 2.793 1.00 124.80 ? 190 ILE A CB 1 ATOM 1166 C CG1 . ILE A 1 159 ? 39.661 -30.401 2.174 1.00 121.91 ? 190 ILE A CG1 1 ATOM 1167 C CG2 . ILE A 1 159 ? 37.573 -29.153 1.768 1.00 129.69 ? 190 ILE A CG2 1 ATOM 1168 C CD1 . ILE A 1 159 ? 39.480 -31.006 0.797 1.00 122.09 ? 190 ILE A CD1 1 ATOM 1169 N N . GLU A 1 160 ? 36.217 -28.629 4.432 1.00 139.63 ? 191 GLU A N 1 ATOM 1170 C CA . GLU A 1 160 ? 35.009 -27.800 4.496 1.00 133.32 ? 191 GLU A CA 1 ATOM 1171 C C . GLU A 1 160 ? 35.199 -26.544 5.339 1.00 142.36 ? 191 GLU A C 1 ATOM 1172 O O . GLU A 1 160 ? 34.985 -25.427 4.864 1.00 143.04 ? 191 GLU A O 1 ATOM 1173 C CB . GLU A 1 160 ? 33.833 -28.612 5.040 1.00 121.63 ? 191 GLU A CB 1 ATOM 1174 N N . ASN A 1 161 ? 35.601 -26.737 6.593 1.00 145.89 ? 192 ASN A N 1 ATOM 1175 C CA . ASN A 1 161 ? 35.833 -25.625 7.521 1.00 153.60 ? 192 ASN A CA 1 ATOM 1176 C C . ASN A 1 161 ? 37.299 -25.167 7.616 1.00 154.40 ? 192 ASN A C 1 ATOM 1177 O O . ASN A 1 161 ? 37.892 -25.156 8.702 1.00 152.44 ? 192 ASN A O 1 ATOM 1178 C CB . ASN A 1 161 ? 35.285 -25.959 8.920 1.00 157.61 ? 192 ASN A CB 1 ATOM 1179 C CG . ASN A 1 161 ? 35.801 -27.291 9.458 1.00 154.63 ? 192 ASN A CG 1 ATOM 1180 O OD1 . ASN A 1 161 ? 36.084 -28.216 8.696 1.00 147.49 ? 192 ASN A OD1 1 ATOM 1181 N ND2 . ASN A 1 161 ? 35.916 -27.392 10.782 1.00 155.40 ? 192 ASN A ND2 1 ATOM 1182 N N . SER A 1 162 ? 37.875 -24.786 6.479 1.00 153.50 ? 193 SER A N 1 ATOM 1183 C CA . SER A 1 162 ? 39.252 -24.299 6.443 1.00 152.15 ? 193 SER A CA 1 ATOM 1184 C C . SER A 1 162 ? 39.358 -23.068 5.557 1.00 153.24 ? 193 SER A C 1 ATOM 1185 O O . SER A 1 162 ? 38.882 -23.068 4.415 1.00 147.43 ? 193 SER A O 1 ATOM 1186 C CB . SER A 1 162 ? 40.208 -25.390 5.954 1.00 147.02 ? 193 SER A CB 1 ATOM 1187 N N . PHE A 1 163 ? 39.977 -22.020 6.099 1.00 156.40 ? 194 PHE A N 1 ATOM 1188 C CA . PHE A 1 163 ? 40.155 -20.759 5.383 1.00 156.22 ? 194 PHE A CA 1 ATOM 1189 C C . PHE A 1 163 ? 40.986 -20.981 4.128 1.00 154.88 ? 194 PHE A C 1 ATOM 1190 O O . PHE A 1 163 ? 40.813 -20.278 3.128 1.00 151.29 ? 194 PHE A O 1 ATOM 1191 C CB . PHE A 1 163 ? 40.827 -19.712 6.277 1.00 146.64 ? 194 PHE A CB 1 ATOM 1192 N N . VAL A 1 164 ? 41.880 -21.968 4.195 1.00 152.90 ? 195 VAL A N 1 ATOM 1193 C CA . VAL A 1 164 ? 42.776 -22.314 3.089 1.00 147.52 ? 195 VAL A CA 1 ATOM 1194 C C . VAL A 1 164 ? 42.049 -22.865 1.856 1.00 143.53 ? 195 VAL A C 1 ATOM 1195 O O . VAL A 1 164 ? 40.956 -23.439 1.957 1.00 141.74 ? 195 VAL A O 1 ATOM 1196 C CB . VAL A 1 164 ? 43.882 -23.297 3.539 1.00 143.90 ? 195 VAL A CB 1 ATOM 1197 C CG1 . VAL A 1 164 ? 45.176 -22.547 3.840 1.00 140.44 ? 195 VAL A CG1 1 ATOM 1198 C CG2 . VAL A 1 164 ? 43.417 -24.110 4.750 1.00 144.31 ? 195 VAL A CG2 1 ATOM 1199 N N . GLY A 1 165 ? 42.674 -22.688 0.696 1.00 135.86 ? 196 GLY A N 1 ATOM 1200 C CA . GLY A 1 165 ? 42.017 -22.943 -0.571 1.00 132.30 ? 196 GLY A CA 1 ATOM 1201 C C . GLY A 1 165 ? 42.200 -24.347 -1.097 1.00 132.90 ? 196 GLY A C 1 ATOM 1202 O O . GLY A 1 165 ? 42.703 -24.535 -2.203 1.00 130.76 ? 196 GLY A O 1 ATOM 1203 N N . TRP A 1 166 ? 41.781 -25.330 -0.304 1.00 135.90 ? 197 TRP A N 1 ATOM 1204 C CA . TRP A 1 166 ? 41.848 -26.737 -0.699 1.00 130.28 ? 197 TRP A CA 1 ATOM 1205 C C . TRP A 1 166 ? 40.969 -27.007 -1.913 1.00 127.63 ? 197 TRP A C 1 ATOM 1206 O O . TRP A 1 166 ? 39.834 -26.546 -1.977 1.00 133.84 ? 197 TRP A O 1 ATOM 1207 C CB . TRP A 1 166 ? 41.380 -27.638 0.446 1.00 126.00 ? 197 TRP A CB 1 ATOM 1208 C CG . TRP A 1 166 ? 42.188 -27.530 1.690 1.00 125.57 ? 197 TRP A CG 1 ATOM 1209 C CD1 . TRP A 1 166 ? 41.824 -26.924 2.858 1.00 129.71 ? 197 TRP A CD1 1 ATOM 1210 C CD2 . TRP A 1 166 ? 43.501 -28.049 1.898 1.00 124.88 ? 197 TRP A CD2 1 ATOM 1211 N NE1 . TRP A 1 166 ? 42.836 -27.032 3.781 1.00 128.69 ? 197 TRP A NE1 1 ATOM 1212 C CE2 . TRP A 1 166 ? 43.879 -27.720 3.214 1.00 127.01 ? 197 TRP A CE2 1 ATOM 1213 C CE3 . TRP A 1 166 ? 44.399 -28.763 1.097 1.00 121.47 ? 197 TRP A CE3 1 ATOM 1214 C CZ2 . TRP A 1 166 ? 45.115 -28.084 3.748 1.00 124.22 ? 197 TRP A CZ2 1 ATOM 1215 C CZ3 . TRP A 1 166 ? 45.622 -29.123 1.628 1.00 117.08 ? 197 TRP A CZ3 1 ATOM 1216 C CH2 . TRP A 1 166 ? 45.969 -28.784 2.940 1.00 117.62 ? 197 TRP A CH2 1 ATOM 1217 N N . GLU A 1 167 ? 41.485 -27.762 -2.872 1.00 123.82 ? 198 GLU A N 1 ATOM 1218 C CA . GLU A 1 167 ? 40.671 -28.183 -4.003 1.00 125.42 ? 198 GLU A CA 1 ATOM 1219 C C . GLU A 1 167 ? 40.782 -29.695 -4.196 1.00 129.50 ? 198 GLU A C 1 ATOM 1220 O O . GLU A 1 167 ? 41.727 -30.191 -4.821 1.00 126.34 ? 198 GLU A O 1 ATOM 1221 C CB . GLU A 1 167 ? 41.059 -27.425 -5.280 1.00 121.07 ? 198 GLU A CB 1 ATOM 1222 N N . LEU A 1 168 ? 39.819 -30.425 -3.636 1.00 125.99 ? 199 LEU A N 1 ATOM 1223 C CA . LEU A 1 168 ? 39.783 -31.873 -3.780 1.00 122.17 ? 199 LEU A CA 1 ATOM 1224 C C . LEU A 1 168 ? 39.184 -32.237 -5.130 1.00 120.84 ? 199 LEU A C 1 ATOM 1225 O O . LEU A 1 168 ? 37.974 -32.391 -5.260 1.00 124.86 ? 199 LEU A O 1 ATOM 1226 C CB . LEU A 1 168 ? 38.978 -32.512 -2.645 1.00 123.10 ? 199 LEU A CB 1 ATOM 1227 C CG . LEU A 1 168 ? 38.891 -34.042 -2.639 1.00 122.67 ? 199 LEU A CG 1 ATOM 1228 C CD1 . LEU A 1 168 ? 40.276 -34.646 -2.487 1.00 123.92 ? 199 LEU A CD1 1 ATOM 1229 C CD2 . LEU A 1 168 ? 37.957 -34.550 -1.542 1.00 120.82 ? 199 LEU A CD2 1 ATOM 1230 N N . GLU A 1 169 ? 40.040 -32.375 -6.134 1.00 121.22 ? 200 GLU A N 1 ATOM 1231 C CA . GLU A 1 169 ? 39.577 -32.590 -7.498 1.00 127.53 ? 200 GLU A CA 1 ATOM 1232 C C . GLU A 1 169 ? 38.831 -33.915 -7.692 1.00 131.09 ? 200 GLU A C 1 ATOM 1233 O O . GLU A 1 169 ? 37.642 -33.921 -8.024 1.00 133.33 ? 200 GLU A O 1 ATOM 1234 C CB . GLU A 1 169 ? 40.740 -32.451 -8.483 1.00 130.72 ? 200 GLU A CB 1 ATOM 1235 C CG . GLU A 1 169 ? 41.377 -31.060 -8.461 1.00 133.42 ? 200 GLU A CG 1 ATOM 1236 C CD . GLU A 1 169 ? 42.511 -30.891 -9.466 1.00 142.43 ? 200 GLU A CD 1 ATOM 1237 O OE1 . GLU A 1 169 ? 42.376 -31.362 -10.619 1.00 144.33 ? 200 GLU A OE1 1 ATOM 1238 O OE2 . GLU A 1 169 ? 43.537 -30.272 -9.099 1.00 142.60 ? 200 GLU A OE2 1 ATOM 1239 N N . GLU A 1 170 ? 39.522 -35.030 -7.482 1.00 129.68 ? 201 GLU A N 1 ATOM 1240 C CA . GLU A 1 170 ? 38.898 -36.341 -7.653 1.00 130.68 ? 201 GLU A CA 1 ATOM 1241 C C . GLU A 1 170 ? 39.007 -37.245 -6.430 1.00 127.76 ? 201 GLU A C 1 ATOM 1242 O O . GLU A 1 170 ? 39.893 -37.083 -5.588 1.00 126.25 ? 201 GLU A O 1 ATOM 1243 C CB . GLU A 1 170 ? 39.463 -37.064 -8.883 1.00 132.35 ? 201 GLU A CB 1 ATOM 1244 C CG . GLU A 1 170 ? 38.769 -36.690 -10.180 1.00 137.67 ? 201 GLU A CG 1 ATOM 1245 C CD . GLU A 1 170 ? 37.271 -36.963 -10.134 1.00 148.92 ? 201 GLU A CD 1 ATOM 1246 O OE1 . GLU A 1 170 ? 36.878 -38.076 -9.710 1.00 146.25 ? 201 GLU A OE1 1 ATOM 1247 O OE2 . GLU A 1 170 ? 36.488 -36.065 -10.523 1.00 150.93 ? 201 GLU A OE2 1 ATOM 1248 N N . VAL A 1 171 ? 38.081 -38.193 -6.344 1.00 125.71 ? 202 VAL A N 1 ATOM 1249 C CA . VAL A 1 171 ? 38.153 -39.261 -5.363 1.00 119.87 ? 202 VAL A CA 1 ATOM 1250 C C . VAL A 1 171 ? 37.797 -40.550 -6.076 1.00 115.75 ? 202 VAL A C 1 ATOM 1251 O O . VAL A 1 171 ? 36.703 -40.687 -6.604 1.00 122.27 ? 202 VAL A O 1 ATOM 1252 C CB . VAL A 1 171 ? 37.177 -39.044 -4.204 1.00 114.13 ? 202 VAL A CB 1 ATOM 1253 C CG1 . VAL A 1 171 ? 37.372 -40.124 -3.162 1.00 115.53 ? 202 VAL A CG1 1 ATOM 1254 C CG2 . VAL A 1 171 ? 37.376 -37.670 -3.589 1.00 114.73 ? 202 VAL A CG2 1 ATOM 1255 N N . LEU A 1 172 ? 38.728 -41.490 -6.118 1.00 114.85 ? 203 LEU A N 1 ATOM 1256 C CA . LEU A 1 172 ? 38.478 -42.735 -6.829 1.00 122.55 ? 203 LEU A CA 1 ATOM 1257 C C . LEU A 1 172 ? 38.237 -43.877 -5.847 1.00 126.48 ? 203 LEU A C 1 ATOM 1258 O O . LEU A 1 172 ? 38.450 -43.732 -4.640 1.00 125.58 ? 203 LEU A O 1 ATOM 1259 C CB . LEU A 1 172 ? 39.627 -43.071 -7.790 1.00 123.69 ? 203 LEU A CB 1 ATOM 1260 C CG . LEU A 1 172 ? 40.130 -41.978 -8.745 1.00 124.24 ? 203 LEU A CG 1 ATOM 1261 C CD1 . LEU A 1 172 ? 40.643 -42.585 -10.045 1.00 119.43 ? 203 LEU A CD1 1 ATOM 1262 C CD2 . LEU A 1 172 ? 39.049 -40.948 -9.036 1.00 126.29 ? 203 LEU A CD2 1 ATOM 1263 N N . LEU A 1 173 ? 37.779 -45.009 -6.368 1.00 123.95 ? 204 LEU A N 1 ATOM 1264 C CA . LEU A 1 173 ? 37.472 -46.158 -5.533 1.00 122.68 ? 204 LEU A CA 1 ATOM 1265 C C . LEU A 1 173 ? 37.698 -47.407 -6.355 1.00 125.89 ? 204 LEU A C 1 ATOM 1266 O O . LEU A 1 173 ? 36.877 -47.768 -7.194 1.00 132.01 ? 204 LEU A O 1 ATOM 1267 C CB . LEU A 1 173 ? 36.029 -46.088 -5.039 1.00 122.36 ? 204 LEU A CB 1 ATOM 1268 C CG . LEU A 1 173 ? 35.594 -47.149 -4.032 1.00 120.36 ? 204 LEU A CG 1 ATOM 1269 C CD1 . LEU A 1 173 ? 36.578 -47.239 -2.884 1.00 121.09 ? 204 LEU A CD1 1 ATOM 1270 C CD2 . LEU A 1 173 ? 34.210 -46.828 -3.515 1.00 122.45 ? 204 LEU A CD2 1 ATOM 1271 N N . LEU A 1 174 ? 38.819 -48.068 -6.113 1.00 121.48 ? 205 LEU A N 1 ATOM 1272 C CA . LEU A 1 174 ? 39.291 -49.088 -7.033 1.00 128.51 ? 205 LEU A CA 1 ATOM 1273 C C . LEU A 1 174 ? 38.800 -50.510 -6.751 1.00 139.21 ? 205 LEU A C 1 ATOM 1274 O O . LEU A 1 174 ? 39.223 -51.155 -5.788 1.00 141.82 ? 205 LEU A O 1 ATOM 1275 C CB . LEU A 1 174 ? 40.815 -49.063 -7.094 1.00 127.78 ? 205 LEU A CB 1 ATOM 1276 C CG . LEU A 1 174 ? 41.437 -47.713 -7.440 1.00 123.71 ? 205 LEU A CG 1 ATOM 1277 C CD1 . LEU A 1 174 ? 42.822 -47.954 -7.995 1.00 115.13 ? 205 LEU A CD1 1 ATOM 1278 C CD2 . LEU A 1 174 ? 40.578 -46.936 -8.431 1.00 121.20 ? 205 LEU A CD2 1 ATOM 1279 N N . ASP A 1 175 ? 37.916 -51.002 -7.611 1.00 137.76 ? 206 ASP A N 1 ATOM 1280 C CA . ASP A 1 175 ? 37.551 -52.407 -7.576 1.00 139.45 ? 206 ASP A CA 1 ATOM 1281 C C . ASP A 1 175 ? 38.707 -53.220 -8.147 1.00 137.73 ? 206 ASP A C 1 ATOM 1282 O O . ASP A 1 175 ? 38.845 -53.351 -9.360 1.00 142.70 ? 206 ASP A O 1 ATOM 1283 C CB . ASP A 1 175 ? 36.270 -52.644 -8.386 1.00 145.40 ? 206 ASP A CB 1 ATOM 1284 C CG . ASP A 1 175 ? 35.949 -54.128 -8.576 1.00 151.27 ? 206 ASP A CG 1 ATOM 1285 O OD1 . ASP A 1 175 ? 36.616 -54.986 -7.952 1.00 147.71 ? 206 ASP A OD1 1 ATOM 1286 O OD2 . ASP A 1 175 ? 35.018 -54.435 -9.356 1.00 152.07 ? 206 ASP A OD2 1 ATOM 1287 N N . MET A 1 176 ? 39.552 -53.752 -7.275 1.00 131.70 ? 207 MET A N 1 ATOM 1288 C CA . MET A 1 176 ? 40.632 -54.623 -7.725 1.00 139.99 ? 207 MET A CA 1 ATOM 1289 C C . MET A 1 176 ? 40.088 -55.998 -8.138 1.00 152.95 ? 207 MET A C 1 ATOM 1290 O O . MET A 1 176 ? 38.990 -56.393 -7.729 1.00 153.59 ? 207 MET A O 1 ATOM 1291 C CB . MET A 1 176 ? 41.671 -54.785 -6.618 1.00 141.09 ? 207 MET A CB 1 ATOM 1292 C CG . MET A 1 176 ? 41.948 -53.500 -5.842 1.00 142.13 ? 207 MET A CG 1 ATOM 1293 S SD . MET A 1 176 ? 43.161 -52.397 -6.616 1.00 141.67 ? 207 MET A SD 1 ATOM 1294 C CE . MET A 1 176 ? 44.693 -53.284 -6.305 1.00 114.21 ? 207 MET A CE 1 ATOM 1295 N N . SER A 1 177 ? 40.856 -56.724 -8.949 1.00 156.84 ? 208 SER A N 1 ATOM 1296 C CA . SER A 1 177 ? 40.480 -58.077 -9.373 1.00 153.60 ? 208 SER A CA 1 ATOM 1297 C C . SER A 1 177 ? 41.643 -58.811 -10.051 1.00 151.52 ? 208 SER A C 1 ATOM 1298 O O . SER A 1 177 ? 41.527 -59.289 -11.181 1.00 150.35 ? 208 SER A O 1 ATOM 1299 C CB . SER A 1 177 ? 39.250 -58.045 -10.286 1.00 143.43 ? 208 SER A CB 1 ATOM 1300 O OG . SER A 1 177 ? 38.073 -57.799 -9.536 1.00 136.46 ? 208 SER A OG 1 ATOM 1301 N N . SER A 1 183 ? 42.416 -55.508 -15.590 1.00 159.01 ? 214 SER A N 1 ATOM 1302 C CA . SER A 1 183 ? 42.940 -54.263 -15.030 1.00 166.63 ? 214 SER A CA 1 ATOM 1303 C C . SER A 1 183 ? 42.133 -53.037 -15.470 1.00 168.67 ? 214 SER A C 1 ATOM 1304 O O . SER A 1 183 ? 42.660 -52.149 -16.152 1.00 165.03 ? 214 SER A O 1 ATOM 1305 C CB . SER A 1 183 ? 44.416 -54.082 -15.404 1.00 162.49 ? 214 SER A CB 1 ATOM 1306 N N . LYS A 1 184 ? 40.861 -52.992 -15.071 1.00 167.07 ? 215 LYS A N 1 ATOM 1307 C CA . LYS A 1 184 ? 39.979 -51.864 -15.381 1.00 162.84 ? 215 LYS A CA 1 ATOM 1308 C C . LYS A 1 184 ? 40.421 -50.594 -14.655 1.00 159.82 ? 215 LYS A C 1 ATOM 1309 O O . LYS A 1 184 ? 39.927 -49.498 -14.940 1.00 152.48 ? 215 LYS A O 1 ATOM 1310 C CB . LYS A 1 184 ? 38.529 -52.198 -15.018 1.00 155.96 ? 215 LYS A CB 1 ATOM 1311 N N . ILE A 1 185 ? 41.350 -50.756 -13.714 1.00 160.90 ? 216 ILE A N 1 ATOM 1312 C CA . ILE A 1 185 ? 41.938 -49.635 -12.991 1.00 152.63 ? 216 ILE A CA 1 ATOM 1313 C C . ILE A 1 185 ? 42.366 -48.531 -13.962 1.00 152.78 ? 216 ILE A C 1 ATOM 1314 O O . ILE A 1 185 ? 41.979 -47.373 -13.801 1.00 146.51 ? 216 ILE A O 1 ATOM 1315 C CB . ILE A 1 185 ? 43.146 -50.086 -12.133 1.00 132.51 ? 216 ILE A CB 1 ATOM 1316 N N . GLN A 1 186 ? 43.147 -48.904 -14.978 1.00 154.75 ? 217 GLN A N 1 ATOM 1317 C CA . GLN A 1 186 ? 43.673 -47.952 -15.961 1.00 145.62 ? 217 GLN A CA 1 ATOM 1318 C C . GLN A 1 186 ? 42.662 -46.866 -16.350 1.00 143.64 ? 217 GLN A C 1 ATOM 1319 O O . GLN A 1 186 ? 42.925 -45.678 -16.171 1.00 140.89 ? 217 GLN A O 1 ATOM 1320 C CB . GLN A 1 186 ? 44.191 -48.682 -17.208 1.00 136.31 ? 217 GLN A CB 1 ATOM 1321 N N . ASN A 1 187 ? 41.506 -47.268 -16.869 1.00 147.82 ? 218 ASN A N 1 ATOM 1322 C CA . ASN A 1 187 ? 40.489 -46.298 -17.268 1.00 148.33 ? 218 ASN A CA 1 ATOM 1323 C C . ASN A 1 187 ? 40.164 -45.310 -16.147 1.00 148.42 ? 218 ASN A C 1 ATOM 1324 O O . ASN A 1 187 ? 39.822 -44.158 -16.408 1.00 147.93 ? 218 ASN A O 1 ATOM 1325 C CB . ASN A 1 187 ? 39.216 -46.997 -17.754 1.00 143.11 ? 218 ASN A CB 1 ATOM 1326 N N . GLN A 1 188 ? 40.282 -45.763 -14.901 1.00 147.74 ? 219 GLN A N 1 ATOM 1327 C CA . GLN A 1 188 ? 40.005 -44.910 -13.747 1.00 144.57 ? 219 GLN A CA 1 ATOM 1328 C C . GLN A 1 188 ? 41.171 -43.980 -13.439 1.00 142.02 ? 219 GLN A C 1 ATOM 1329 O O . GLN A 1 188 ? 41.008 -42.758 -13.397 1.00 139.14 ? 219 GLN A O 1 ATOM 1330 C CB . GLN A 1 188 ? 39.685 -45.746 -12.501 1.00 146.78 ? 219 GLN A CB 1 ATOM 1331 C CG . GLN A 1 188 ? 38.317 -46.415 -12.508 1.00 150.81 ? 219 GLN A CG 1 ATOM 1332 C CD . GLN A 1 188 ? 37.711 -46.529 -11.114 1.00 150.45 ? 219 GLN A CD 1 ATOM 1333 O OE1 . GLN A 1 188 ? 37.338 -45.521 -10.498 1.00 143.10 ? 219 GLN A OE1 1 ATOM 1334 N NE2 . GLN A 1 188 ? 37.598 -47.763 -10.614 1.00 143.69 ? 219 GLN A NE2 1 ATOM 1335 N N . LEU A 1 189 ? 42.342 -44.574 -13.216 1.00 142.14 ? 220 LEU A N 1 ATOM 1336 C CA . LEU A 1 189 ? 43.530 -43.829 -12.801 1.00 137.68 ? 220 LEU A CA 1 ATOM 1337 C C . LEU A 1 189 ? 43.958 -42.815 -13.868 1.00 141.44 ? 220 LEU A C 1 ATOM 1338 O O . LEU A 1 189 ? 44.612 -41.811 -13.564 1.00 138.23 ? 220 LEU A O 1 ATOM 1339 C CB . LEU A 1 189 ? 44.677 -44.786 -12.437 1.00 113.52 ? 220 LEU A CB 1 ATOM 1340 N N . LYS A 1 190 ? 43.570 -43.073 -15.115 1.00 144.06 ? 221 LYS A N 1 ATOM 1341 C CA . LYS A 1 190 ? 43.857 -42.152 -16.207 1.00 140.84 ? 221 LYS A CA 1 ATOM 1342 C C . LYS A 1 190 ? 43.118 -40.835 -15.985 1.00 142.29 ? 221 LYS A C 1 ATOM 1343 O O . LYS A 1 190 ? 43.599 -39.774 -16.375 1.00 144.37 ? 221 LYS A O 1 ATOM 1344 C CB . LYS A 1 190 ? 43.466 -42.766 -17.555 1.00 137.98 ? 221 LYS A CB 1 ATOM 1345 N N . LYS A 1 191 ? 41.956 -40.910 -15.339 1.00 140.57 ? 222 LYS A N 1 ATOM 1346 C CA . LYS A 1 191 ? 41.107 -39.739 -15.110 1.00 138.43 ? 222 LYS A CA 1 ATOM 1347 C C . LYS A 1 191 ? 41.675 -38.757 -14.075 1.00 137.50 ? 222 LYS A C 1 ATOM 1348 O O . LYS A 1 191 ? 40.988 -37.822 -13.657 1.00 133.42 ? 222 LYS A O 1 ATOM 1349 C CB . LYS A 1 191 ? 39.699 -40.183 -14.694 1.00 134.12 ? 222 LYS A CB 1 ATOM 1350 N N . LEU A 1 192 ? 42.928 -38.965 -13.675 1.00 141.12 ? 223 LEU A N 1 ATOM 1351 C CA . LEU A 1 192 ? 43.552 -38.166 -12.615 1.00 139.11 ? 223 LEU A CA 1 ATOM 1352 C C . LEU A 1 192 ? 44.268 -36.920 -13.126 1.00 135.32 ? 223 LEU A C 1 ATOM 1353 O O . LEU A 1 192 ? 45.140 -37.001 -13.994 1.00 134.51 ? 223 LEU A O 1 ATOM 1354 C CB . LEU A 1 192 ? 44.536 -39.018 -11.807 1.00 135.29 ? 223 LEU A CB 1 ATOM 1355 C CG . LEU A 1 192 ? 43.988 -39.867 -10.661 1.00 129.71 ? 223 LEU A CG 1 ATOM 1356 C CD1 . LEU A 1 192 ? 45.142 -40.516 -9.938 1.00 121.73 ? 223 LEU A CD1 1 ATOM 1357 C CD2 . LEU A 1 192 ? 43.152 -39.029 -9.698 1.00 129.88 ? 223 LEU A CD2 1 ATOM 1358 N N . GLN A 1 193 ? 43.912 -35.771 -12.565 1.00 133.58 ? 224 GLN A N 1 ATOM 1359 C CA . GLN A 1 193 ? 44.516 -34.509 -12.981 1.00 141.23 ? 224 GLN A CA 1 ATOM 1360 C C . GLN A 1 193 ? 45.544 -33.978 -11.971 1.00 139.68 ? 224 GLN A C 1 ATOM 1361 O O . GLN A 1 193 ? 46.673 -33.648 -12.341 1.00 139.80 ? 224 GLN A O 1 ATOM 1362 C CB . GLN A 1 193 ? 43.432 -33.456 -13.253 1.00 139.06 ? 224 GLN A CB 1 ATOM 1363 N N . SER A 1 194 ? 45.144 -33.914 -10.703 1.00 135.02 ? 225 SER A N 1 ATOM 1364 C CA . SER A 1 194 ? 45.955 -33.330 -9.633 1.00 126.66 ? 225 SER A CA 1 ATOM 1365 C C . SER A 1 194 ? 47.416 -33.786 -9.599 1.00 127.06 ? 225 SER A C 1 ATOM 1366 O O . SER A 1 194 ? 47.753 -34.859 -10.096 1.00 126.27 ? 225 SER A O 1 ATOM 1367 C CB . SER A 1 194 ? 45.303 -33.609 -8.279 1.00 125.82 ? 225 SER A CB 1 ATOM 1368 O OG . SER A 1 194 ? 43.912 -33.363 -8.337 1.00 127.84 ? 225 SER A OG 1 ATOM 1369 N N . PRO A 1 195 ? 48.287 -32.954 -9.000 1.00 128.69 ? 226 PRO A N 1 ATOM 1370 C CA . PRO A 1 195 ? 49.722 -33.188 -8.806 1.00 125.27 ? 226 PRO A CA 1 ATOM 1371 C C . PRO A 1 195 ? 50.004 -33.948 -7.516 1.00 123.01 ? 226 PRO A C 1 ATOM 1372 O O . PRO A 1 195 ? 50.942 -34.746 -7.455 1.00 123.23 ? 226 PRO A O 1 ATOM 1373 C CB . PRO A 1 195 ? 50.288 -31.771 -8.660 1.00 125.91 ? 226 PRO A CB 1 ATOM 1374 C CG . PRO A 1 195 ? 49.115 -30.823 -8.822 1.00 118.37 ? 226 PRO A CG 1 ATOM 1375 C CD . PRO A 1 195 ? 47.902 -31.618 -8.526 1.00 125.07 ? 226 PRO A CD 1 ATOM 1376 N N . ILE A 1 196 ? 49.214 -33.667 -6.484 1.00 121.29 ? 227 ILE A N 1 ATOM 1377 C CA . ILE A 1 196 ? 49.295 -34.398 -5.228 1.00 119.81 ? 227 ILE A CA 1 ATOM 1378 C C . ILE A 1 196 ? 48.198 -35.460 -5.141 1.00 120.46 ? 227 ILE A C 1 ATOM 1379 O O . ILE A 1 196 ? 47.024 -35.200 -5.424 1.00 118.59 ? 227 ILE A O 1 ATOM 1380 C CB . ILE A 1 196 ? 49.217 -33.458 -4.020 1.00 114.48 ? 227 ILE A CB 1 ATOM 1381 C CG1 . ILE A 1 196 ? 50.603 -32.903 -3.707 1.00 112.37 ? 227 ILE A CG1 1 ATOM 1382 C CG2 . ILE A 1 196 ? 48.696 -34.200 -2.807 1.00 115.31 ? 227 ILE A CG2 1 ATOM 1383 C CD1 . ILE A 1 196 ? 51.370 -32.443 -4.922 1.00 116.24 ? 227 ILE A CD1 1 ATOM 1384 N N . ILE A 1 197 ? 48.592 -36.669 -4.766 1.00 117.97 ? 228 ILE A N 1 ATOM 1385 C CA . ILE A 1 197 ? 47.642 -37.758 -4.690 1.00 114.03 ? 228 ILE A CA 1 ATOM 1386 C C . ILE A 1 197 ? 47.780 -38.502 -3.379 1.00 110.83 ? 228 ILE A C 1 ATOM 1387 O O . ILE A 1 197 ? 48.850 -39.009 -3.034 1.00 105.79 ? 228 ILE A O 1 ATOM 1388 C CB . ILE A 1 197 ? 47.818 -38.733 -5.850 1.00 111.78 ? 228 ILE A CB 1 ATOM 1389 C CG1 . ILE A 1 197 ? 47.645 -38.006 -7.177 1.00 113.57 ? 228 ILE A CG1 1 ATOM 1390 C CG2 . ILE A 1 197 ? 46.802 -39.841 -5.755 1.00 115.19 ? 228 ILE A CG2 1 ATOM 1391 C CD1 . ILE A 1 197 ? 48.230 -38.759 -8.345 1.00 114.21 ? 228 ILE A CD1 1 ATOM 1392 N N . LEU A 1 198 ? 46.679 -38.542 -2.645 1.00 109.65 ? 229 LEU A N 1 ATOM 1393 C CA . LEU A 1 198 ? 46.597 -39.327 -1.435 1.00 107.34 ? 229 LEU A CA 1 ATOM 1394 C C . LEU A 1 198 ? 46.074 -40.701 -1.806 1.00 108.04 ? 229 LEU A C 1 ATOM 1395 O O . LEU A 1 198 ? 44.983 -40.828 -2.365 1.00 108.61 ? 229 LEU A O 1 ATOM 1396 C CB . LEU A 1 198 ? 45.647 -38.659 -0.457 1.00 108.28 ? 229 LEU A CB 1 ATOM 1397 C CG . LEU A 1 198 ? 45.939 -37.184 -0.236 1.00 104.45 ? 229 LEU A CG 1 ATOM 1398 C CD1 . LEU A 1 198 ? 45.194 -36.711 0.980 1.00 105.19 ? 229 LEU A CD1 1 ATOM 1399 C CD2 . LEU A 1 198 ? 47.426 -36.986 -0.059 1.00 105.75 ? 229 LEU A CD2 1 ATOM 1400 N N . LEU A 1 199 ? 46.860 -41.727 -1.508 1.00 101.64 ? 230 LEU A N 1 ATOM 1401 C CA . LEU A 1 199 ? 46.500 -43.088 -1.865 1.00 102.78 ? 230 LEU A CA 1 ATOM 1402 C C . LEU A 1 199 ? 46.321 -43.922 -0.617 1.00 105.52 ? 230 LEU A C 1 ATOM 1403 O O . LEU A 1 199 ? 47.285 -44.194 0.092 1.00 108.86 ? 230 LEU A O 1 ATOM 1404 C CB . LEU A 1 199 ? 47.582 -43.717 -2.736 1.00 102.26 ? 230 LEU A CB 1 ATOM 1405 C CG . LEU A 1 199 ? 47.451 -45.229 -2.913 1.00 103.16 ? 230 LEU A CG 1 ATOM 1406 C CD1 . LEU A 1 199 ? 46.261 -45.560 -3.794 1.00 102.04 ? 230 LEU A CD1 1 ATOM 1407 C CD2 . LEU A 1 199 ? 48.723 -45.811 -3.495 1.00 105.92 ? 230 LEU A CD2 1 ATOM 1408 N N . TYR A 1 200 ? 45.088 -44.333 -0.349 1.00 103.06 ? 231 TYR A N 1 ATOM 1409 C CA . TYR A 1 200 ? 44.800 -45.132 0.832 1.00 102.01 ? 231 TYR A CA 1 ATOM 1410 C C . TYR A 1 200 ? 44.531 -46.597 0.479 1.00 102.51 ? 231 TYR A C 1 ATOM 1411 O O . TYR A 1 200 ? 43.538 -46.913 -0.171 1.00 106.23 ? 231 TYR A O 1 ATOM 1412 C CB . TYR A 1 200 ? 43.608 -44.543 1.581 1.00 103.35 ? 231 TYR A CB 1 ATOM 1413 C CG . TYR A 1 200 ? 43.203 -45.368 2.769 1.00 104.42 ? 231 TYR A CG 1 ATOM 1414 C CD1 . TYR A 1 200 ? 43.628 -45.032 4.043 1.00 103.05 ? 231 TYR A CD1 1 ATOM 1415 C CD2 . TYR A 1 200 ? 42.411 -46.495 2.617 1.00 101.75 ? 231 TYR A CD2 1 ATOM 1416 C CE1 . TYR A 1 200 ? 43.271 -45.790 5.132 1.00 105.58 ? 231 TYR A CE1 1 ATOM 1417 C CE2 . TYR A 1 200 ? 42.049 -47.258 3.699 1.00 103.41 ? 231 TYR A CE2 1 ATOM 1418 C CZ . TYR A 1 200 ? 42.483 -46.899 4.956 1.00 105.39 ? 231 TYR A CZ 1 ATOM 1419 O OH . TYR A 1 200 ? 42.130 -47.646 6.049 1.00 105.83 ? 231 TYR A OH 1 ATOM 1420 N N . CYS A 1 201 ? 45.407 -47.491 0.923 1.00 98.07 ? 232 CYS A N 1 ATOM 1421 C CA . CYS A 1 201 ? 45.274 -48.906 0.607 1.00 99.96 ? 232 CYS A CA 1 ATOM 1422 C C . CYS A 1 201 ? 46.342 -49.729 1.325 1.00 101.88 ? 232 CYS A C 1 ATOM 1423 O O . CYS A 1 201 ? 47.142 -49.190 2.080 1.00 105.71 ? 232 CYS A O 1 ATOM 1424 C CB . CYS A 1 201 ? 45.422 -49.106 -0.893 1.00 103.02 ? 232 CYS A CB 1 ATOM 1425 S SG . CYS A 1 201 ? 47.118 -48.894 -1.475 1.00 109.56 ? 232 CYS A SG 1 ATOM 1426 N N . THR A 1 202 ? 46.367 -51.037 1.087 1.00 104.20 ? 233 THR A N 1 ATOM 1427 C CA . THR A 1 202 ? 47.391 -51.884 1.696 1.00 106.25 ? 233 THR A CA 1 ATOM 1428 C C . THR A 1 202 ? 48.701 -51.769 0.943 1.00 104.03 ? 233 THR A C 1 ATOM 1429 O O . THR A 1 202 ? 48.741 -51.257 -0.174 1.00 105.11 ? 233 THR A O 1 ATOM 1430 C CB . THR A 1 202 ? 46.986 -53.364 1.700 1.00 106.25 ? 233 THR A CB 1 ATOM 1431 O OG1 . THR A 1 202 ? 46.766 -53.805 0.355 1.00 104.39 ? 233 THR A OG1 1 ATOM 1432 C CG2 . THR A 1 202 ? 45.731 -53.560 2.508 1.00 104.54 ? 233 THR A CG2 1 ATOM 1433 N N . LYS A 1 203 ? 49.776 -52.250 1.551 1.00 99.31 ? 234 LYS A N 1 ATOM 1434 C CA . LYS A 1 203 ? 51.049 -52.262 0.859 1.00 99.32 ? 234 LYS A CA 1 ATOM 1435 C C . LYS A 1 203 ? 50.935 -53.064 -0.434 1.00 105.62 ? 234 LYS A C 1 ATOM 1436 O O . LYS A 1 203 ? 51.369 -52.603 -1.490 1.00 106.03 ? 234 LYS A O 1 ATOM 1437 C CB . LYS A 1 203 ? 52.142 -52.840 1.748 1.00 96.15 ? 234 LYS A CB 1 ATOM 1438 C CG . LYS A 1 203 ? 53.530 -52.751 1.161 1.00 88.20 ? 234 LYS A CG 1 ATOM 1439 C CD . LYS A 1 203 ? 54.552 -53.069 2.229 1.00 94.69 ? 234 LYS A CD 1 ATOM 1440 C CE . LYS A 1 203 ? 55.956 -52.704 1.787 1.00 103.52 ? 234 LYS A CE 1 ATOM 1441 N NZ . LYS A 1 203 ? 56.989 -53.054 2.809 1.00 108.09 ? 234 LYS A NZ 1 ATOM 1442 N N . GLU A 1 204 ? 50.337 -54.255 -0.353 1.00 109.29 ? 235 GLU A N 1 ATOM 1443 C CA . GLU A 1 204 ? 50.272 -55.154 -1.508 1.00 106.15 ? 235 GLU A CA 1 ATOM 1444 C C . GLU A 1 204 ? 49.384 -54.588 -2.610 1.00 104.65 ? 235 GLU A C 1 ATOM 1445 O O . GLU A 1 204 ? 49.701 -54.700 -3.789 1.00 107.30 ? 235 GLU A O 1 ATOM 1446 C CB . GLU A 1 204 ? 49.832 -56.567 -1.105 1.00 91.54 ? 235 GLU A CB 1 ATOM 1447 N N . GLU A 1 205 ? 48.276 -53.968 -2.231 1.00 101.17 ? 236 GLU A N 1 ATOM 1448 C CA . GLU A 1 205 ? 47.428 -53.338 -3.225 1.00 106.08 ? 236 GLU A CA 1 ATOM 1449 C C . GLU A 1 205 ? 48.226 -52.244 -3.908 1.00 113.83 ? 236 GLU A C 1 ATOM 1450 O O . GLU A 1 205 ? 48.202 -52.105 -5.132 1.00 115.47 ? 236 GLU A O 1 ATOM 1451 C CB . GLU A 1 205 ? 46.185 -52.740 -2.576 1.00 106.33 ? 236 GLU A CB 1 ATOM 1452 C CG . GLU A 1 205 ? 45.059 -53.729 -2.395 1.00 114.82 ? 236 GLU A CG 1 ATOM 1453 C CD . GLU A 1 205 ? 43.952 -53.206 -1.497 1.00 121.67 ? 236 GLU A CD 1 ATOM 1454 O OE1 . GLU A 1 205 ? 43.967 -51.994 -1.180 1.00 114.50 ? 236 GLU A OE1 1 ATOM 1455 O OE2 . GLU A 1 205 ? 43.068 -54.011 -1.108 1.00 129.33 ? 236 GLU A OE2 1 ATOM 1456 N N . ALA A 1 206 ? 48.944 -51.476 -3.096 1.00 112.26 ? 237 ALA A N 1 ATOM 1457 C CA . ALA A 1 206 ? 49.682 -50.324 -3.577 1.00 107.66 ? 237 ALA A CA 1 ATOM 1458 C C . ALA A 1 206 ? 50.632 -50.695 -4.706 1.00 112.12 ? 237 ALA A C 1 ATOM 1459 O O . ALA A 1 206 ? 50.746 -49.964 -5.692 1.00 114.73 ? 237 ALA A O 1 ATOM 1460 C CB . ALA A 1 206 ? 50.435 -49.684 -2.436 1.00 104.59 ? 237 ALA A CB 1 ATOM 1461 N N . THR A 1 207 ? 51.307 -51.833 -4.575 1.00 108.88 ? 238 THR A N 1 ATOM 1462 C CA . THR A 1 207 ? 52.326 -52.188 -5.557 1.00 112.82 ? 238 THR A CA 1 ATOM 1463 C C . THR A 1 207 ? 51.714 -52.497 -6.923 1.00 115.17 ? 238 THR A C 1 ATOM 1464 O O . THR A 1 207 ? 52.364 -52.321 -7.951 1.00 121.11 ? 238 THR A O 1 ATOM 1465 C CB . THR A 1 207 ? 53.241 -53.349 -5.100 1.00 106.01 ? 238 THR A CB 1 ATOM 1466 O OG1 . THR A 1 207 ? 52.726 -54.589 -5.586 1.00 113.76 ? 238 THR A OG1 1 ATOM 1467 C CG2 . THR A 1 207 ? 53.348 -53.401 -3.593 1.00 105.81 ? 238 THR A CG2 1 ATOM 1468 N N . TYR A 1 208 ? 50.467 -52.949 -6.944 1.00 111.66 ? 239 TYR A N 1 ATOM 1469 C CA . TYR A 1 208 ? 49.795 -53.150 -8.220 1.00 116.15 ? 239 TYR A CA 1 ATOM 1470 C C . TYR A 1 208 ? 49.419 -51.781 -8.752 1.00 117.53 ? 239 TYR A C 1 ATOM 1471 O O . TYR A 1 208 ? 49.727 -51.427 -9.891 1.00 120.52 ? 239 TYR A O 1 ATOM 1472 C CB . TYR A 1 208 ? 48.549 -54.030 -8.070 1.00 113.88 ? 239 TYR A CB 1 ATOM 1473 N N . ILE A 1 209 ? 48.770 -51.000 -7.900 1.00 115.57 ? 240 ILE A N 1 ATOM 1474 C CA . ILE A 1 209 ? 48.301 -49.683 -8.291 1.00 115.88 ? 240 ILE A CA 1 ATOM 1475 C C . ILE A 1 209 ? 49.422 -48.852 -8.897 1.00 117.52 ? 240 ILE A C 1 ATOM 1476 O O . ILE A 1 209 ? 49.201 -48.133 -9.863 1.00 119.65 ? 240 ILE A O 1 ATOM 1477 C CB . ILE A 1 209 ? 47.682 -48.935 -7.107 1.00 115.32 ? 240 ILE A CB 1 ATOM 1478 C CG1 . ILE A 1 209 ? 46.527 -49.750 -6.521 1.00 114.75 ? 240 ILE A CG1 1 ATOM 1479 C CG2 . ILE A 1 209 ? 47.210 -47.563 -7.543 1.00 111.83 ? 240 ILE A CG2 1 ATOM 1480 C CD1 . ILE A 1 209 ? 45.959 -49.192 -5.232 1.00 114.11 ? 240 ILE A CD1 1 ATOM 1481 N N . PHE A 1 210 ? 50.625 -48.957 -8.344 1.00 115.21 ? 241 PHE A N 1 ATOM 1482 C CA . PHE A 1 210 ? 51.747 -48.189 -8.874 1.00 120.27 ? 241 PHE A CA 1 ATOM 1483 C C . PHE A 1 210 ? 52.235 -48.703 -10.220 1.00 128.15 ? 241 PHE A C 1 ATOM 1484 O O . PHE A 1 210 ? 52.426 -47.919 -11.155 1.00 127.60 ? 241 PHE A O 1 ATOM 1485 C CB . PHE A 1 210 ? 52.894 -48.132 -7.876 1.00 117.93 ? 241 PHE A CB 1 ATOM 1486 C CG . PHE A 1 210 ? 52.684 -47.125 -6.802 1.00 116.04 ? 241 PHE A CG 1 ATOM 1487 C CD1 . PHE A 1 210 ? 52.233 -45.855 -7.121 1.00 116.79 ? 241 PHE A CD1 1 ATOM 1488 C CD2 . PHE A 1 210 ? 52.928 -47.438 -5.481 1.00 115.11 ? 241 PHE A CD2 1 ATOM 1489 C CE1 . PHE A 1 210 ? 52.025 -44.915 -6.142 1.00 114.48 ? 241 PHE A CE1 1 ATOM 1490 C CE2 . PHE A 1 210 ? 52.724 -46.502 -4.493 1.00 113.98 ? 241 PHE A CE2 1 ATOM 1491 C CZ . PHE A 1 210 ? 52.268 -45.237 -4.824 1.00 114.77 ? 241 PHE A CZ 1 ATOM 1492 N N . GLU A 1 211 ? 52.438 -50.016 -10.309 1.00 128.63 ? 242 GLU A N 1 ATOM 1493 C CA . GLU A 1 211 ? 52.837 -50.656 -11.559 1.00 129.72 ? 242 GLU A CA 1 ATOM 1494 C C . GLU A 1 211 ? 51.957 -50.176 -12.713 1.00 131.41 ? 242 GLU A C 1 ATOM 1495 O O . GLU A 1 211 ? 52.430 -49.997 -13.834 1.00 136.70 ? 242 GLU A O 1 ATOM 1496 C CB . GLU A 1 211 ? 52.769 -52.182 -11.435 1.00 126.57 ? 242 GLU A CB 1 ATOM 1497 N N . VAL A 1 212 ? 50.678 -49.954 -12.431 1.00 125.01 ? 243 VAL A N 1 ATOM 1498 C CA . VAL A 1 212 ? 49.764 -49.435 -13.438 1.00 128.97 ? 243 VAL A CA 1 ATOM 1499 C C . VAL A 1 212 ? 49.998 -47.956 -13.737 1.00 133.96 ? 243 VAL A C 1 ATOM 1500 O O . VAL A 1 212 ? 50.208 -47.580 -14.889 1.00 135.53 ? 243 VAL A O 1 ATOM 1501 C CB . VAL A 1 212 ? 48.311 -49.617 -13.012 1.00 127.98 ? 243 VAL A CB 1 ATOM 1502 C CG1 . VAL A 1 212 ? 47.373 -48.938 -14.009 1.00 129.43 ? 243 VAL A CG1 1 ATOM 1503 C CG2 . VAL A 1 212 ? 48.000 -51.089 -12.882 1.00 127.80 ? 243 VAL A CG2 1 ATOM 1504 N N . ALA A 1 213 ? 49.949 -47.123 -12.700 1.00 133.94 ? 244 ALA A N 1 ATOM 1505 C CA . ALA A 1 213 ? 50.147 -45.685 -12.856 1.00 132.06 ? 244 ALA A CA 1 ATOM 1506 C C . ALA A 1 213 ? 51.448 -45.390 -13.582 1.00 138.29 ? 244 ALA A C 1 ATOM 1507 O O . ALA A 1 213 ? 51.508 -44.474 -14.402 1.00 140.49 ? 244 ALA A O 1 ATOM 1508 C CB . ALA A 1 213 ? 50.131 -44.985 -11.504 1.00 125.34 ? 244 ALA A CB 1 ATOM 1509 N N . ASN A 1 214 ? 52.488 -46.167 -13.278 1.00 137.10 ? 245 ASN A N 1 ATOM 1510 C CA . ASN A 1 214 ? 53.802 -45.968 -13.897 1.00 143.38 ? 245 ASN A CA 1 ATOM 1511 C C . ASN A 1 214 ? 53.756 -46.067 -15.420 1.00 143.91 ? 245 ASN A C 1 ATOM 1512 O O . ASN A 1 214 ? 54.321 -45.225 -16.122 1.00 144.61 ? 245 ASN A O 1 ATOM 1513 C CB . ASN A 1 214 ? 54.844 -46.935 -13.320 1.00 141.36 ? 245 ASN A CB 1 ATOM 1514 C CG . ASN A 1 214 ? 55.330 -46.519 -11.935 1.00 143.17 ? 245 ASN A CG 1 ATOM 1515 O OD1 . ASN A 1 214 ? 55.754 -45.377 -11.724 1.00 142.54 ? 245 ASN A OD1 1 ATOM 1516 N ND2 . ASN A 1 214 ? 55.275 -47.450 -10.986 1.00 136.41 ? 245 ASN A ND2 1 ATOM 1517 N N . SER A 1 215 ? 53.079 -47.097 -15.924 1.00 143.90 ? 246 SER A N 1 ATOM 1518 C CA . SER A 1 215 ? 52.825 -47.219 -17.358 1.00 146.08 ? 246 SER A CA 1 ATOM 1519 C C . SER A 1 215 ? 51.555 -46.452 -17.759 1.00 141.36 ? 246 SER A C 1 ATOM 1520 O O . SER A 1 215 ? 50.756 -46.903 -18.581 1.00 136.87 ? 246 SER A O 1 ATOM 1521 C CB . SER A 1 215 ? 52.766 -48.689 -17.790 1.00 143.93 ? 246 SER A CB 1 ATOM 1522 O OG . SER A 1 215 ? 52.031 -49.468 -16.865 1.00 145.99 ? 246 SER A OG 1 ATOM 1523 N N . VAL A 1 216 ? 51.378 -45.291 -17.141 1.00 139.67 ? 247 VAL A N 1 ATOM 1524 C CA . VAL A 1 216 ? 50.370 -44.324 -17.544 1.00 140.94 ? 247 VAL A CA 1 ATOM 1525 C C . VAL A 1 216 ? 50.954 -42.957 -17.203 1.00 144.36 ? 247 VAL A C 1 ATOM 1526 O O . VAL A 1 216 ? 50.327 -41.915 -17.419 1.00 142.37 ? 247 VAL A O 1 ATOM 1527 C CB . VAL A 1 216 ? 49.026 -44.531 -16.815 1.00 135.94 ? 247 VAL A CB 1 ATOM 1528 C CG1 . VAL A 1 216 ? 47.916 -43.743 -17.502 1.00 132.50 ? 247 VAL A CG1 1 ATOM 1529 C CG2 . VAL A 1 216 ? 48.667 -45.995 -16.774 1.00 132.58 ? 247 VAL A CG2 1 ATOM 1530 N N . GLY A 1 217 ? 52.168 -42.981 -16.655 1.00 141.64 ? 248 GLY A N 1 ATOM 1531 C CA . GLY A 1 217 ? 52.907 -41.768 -16.357 1.00 144.68 ? 248 GLY A CA 1 ATOM 1532 C C . GLY A 1 217 ? 52.518 -41.037 -15.084 1.00 143.84 ? 248 GLY A C 1 ATOM 1533 O O . GLY A 1 217 ? 53.349 -40.331 -14.507 1.00 144.41 ? 248 GLY A O 1 ATOM 1534 N N . LEU A 1 218 ? 51.266 -41.193 -14.648 1.00 143.83 ? 249 LEU A N 1 ATOM 1535 C CA . LEU A 1 218 ? 50.775 -40.516 -13.443 1.00 140.03 ? 249 LEU A CA 1 ATOM 1536 C C . LEU A 1 218 ? 51.719 -40.682 -12.234 1.00 140.57 ? 249 LEU A C 1 ATOM 1537 O O . LEU A 1 218 ? 51.537 -40.033 -11.202 1.00 139.95 ? 249 LEU A O 1 ATOM 1538 C CB . LEU A 1 218 ? 49.346 -40.964 -13.100 1.00 121.80 ? 249 LEU A CB 1 ATOM 1539 N N . THR A 1 219 ? 52.725 -41.546 -12.367 1.00 137.67 ? 250 THR A N 1 ATOM 1540 C CA . THR A 1 219 ? 53.766 -41.677 -11.352 1.00 136.20 ? 250 THR A CA 1 ATOM 1541 C C . THR A 1 219 ? 55.106 -41.246 -11.928 1.00 144.16 ? 250 THR A C 1 ATOM 1542 O O . THR A 1 219 ? 55.665 -41.934 -12.786 1.00 144.52 ? 250 THR A O 1 ATOM 1543 C CB . THR A 1 219 ? 53.899 -43.121 -10.837 1.00 130.13 ? 250 THR A CB 1 ATOM 1544 N N . GLY A 1 220 ? 55.609 -40.106 -11.459 1.00 140.88 ? 251 GLY A N 1 ATOM 1545 C CA . GLY A 1 220 ? 56.894 -39.588 -11.899 1.00 142.52 ? 251 GLY A CA 1 ATOM 1546 C C . GLY A 1 220 ? 57.182 -38.190 -11.380 1.00 143.24 ? 251 GLY A C 1 ATOM 1547 O O . GLY A 1 220 ? 57.012 -37.908 -10.190 1.00 140.14 ? 251 GLY A O 1 ATOM 1548 N N . TYR A 1 221 ? 57.641 -37.313 -12.271 1.00 145.38 ? 252 TYR A N 1 ATOM 1549 C CA . TYR A 1 221 ? 57.793 -35.901 -11.934 1.00 147.97 ? 252 TYR A CA 1 ATOM 1550 C C . TYR A 1 221 ? 56.495 -35.184 -12.258 1.00 141.49 ? 252 TYR A C 1 ATOM 1551 O O . TYR A 1 221 ? 55.849 -35.477 -13.268 1.00 135.84 ? 252 TYR A O 1 ATOM 1552 C CB . TYR A 1 221 ? 58.946 -35.250 -12.704 1.00 151.46 ? 252 TYR A CB 1 ATOM 1553 C CG . TYR A 1 221 ? 60.337 -35.669 -12.261 1.00 157.13 ? 252 TYR A CG 1 ATOM 1554 C CD1 . TYR A 1 221 ? 61.007 -34.987 -11.246 1.00 148.90 ? 252 TYR A CD1 1 ATOM 1555 C CD2 . TYR A 1 221 ? 60.989 -36.738 -12.874 1.00 163.45 ? 252 TYR A CD2 1 ATOM 1556 C CE1 . TYR A 1 221 ? 62.287 -35.369 -10.848 1.00 152.05 ? 252 TYR A CE1 1 ATOM 1557 C CE2 . TYR A 1 221 ? 62.268 -37.127 -12.485 1.00 163.15 ? 252 TYR A CE2 1 ATOM 1558 C CZ . TYR A 1 221 ? 62.914 -36.442 -11.474 1.00 158.12 ? 252 TYR A CZ 1 ATOM 1559 O OH . TYR A 1 221 ? 64.183 -36.844 -11.099 1.00 145.95 ? 252 TYR A OH 1 ATOM 1560 N N . GLY A 1 222 ? 56.120 -34.242 -11.401 1.00 139.74 ? 253 GLY A N 1 ATOM 1561 C CA . GLY A 1 222 ? 54.846 -33.564 -11.536 1.00 138.69 ? 253 GLY A CA 1 ATOM 1562 C C . GLY A 1 222 ? 53.830 -34.136 -10.568 1.00 138.42 ? 253 GLY A C 1 ATOM 1563 O O . GLY A 1 222 ? 53.015 -33.404 -10.009 1.00 137.14 ? 253 GLY A O 1 ATOM 1564 N N . TYR A 1 223 ? 53.887 -35.449 -10.363 1.00 136.70 ? 254 TYR A N 1 ATOM 1565 C CA . TYR A 1 223 ? 52.997 -36.116 -9.420 1.00 126.34 ? 254 TYR A CA 1 ATOM 1566 C C . TYR A 1 223 ? 53.744 -36.617 -8.197 1.00 120.34 ? 254 TYR A C 1 ATOM 1567 O O . TYR A 1 223 ? 54.719 -37.359 -8.318 1.00 123.12 ? 254 TYR A O 1 ATOM 1568 C CB . TYR A 1 223 ? 52.296 -37.279 -10.099 1.00 125.89 ? 254 TYR A CB 1 ATOM 1569 C CG . TYR A 1 223 ? 51.538 -36.867 -11.331 1.00 132.10 ? 254 TYR A CG 1 ATOM 1570 C CD1 . TYR A 1 223 ? 50.319 -36.217 -11.229 1.00 133.75 ? 254 TYR A CD1 1 ATOM 1571 C CD2 . TYR A 1 223 ? 52.043 -37.121 -12.598 1.00 136.94 ? 254 TYR A CD2 1 ATOM 1572 C CE1 . TYR A 1 223 ? 49.615 -35.836 -12.357 1.00 141.49 ? 254 TYR A CE1 1 ATOM 1573 C CE2 . TYR A 1 223 ? 51.347 -36.745 -13.736 1.00 140.22 ? 254 TYR A CE2 1 ATOM 1574 C CZ . TYR A 1 223 ? 50.131 -36.102 -13.611 1.00 145.86 ? 254 TYR A CZ 1 ATOM 1575 O OH . TYR A 1 223 ? 49.429 -35.723 -14.739 1.00 148.39 ? 254 TYR A OH 1 ATOM 1576 N N . THR A 1 224 ? 53.295 -36.188 -7.022 1.00 115.96 ? 255 THR A N 1 ATOM 1577 C CA . THR A 1 224 ? 53.804 -36.729 -5.768 1.00 118.32 ? 255 THR A CA 1 ATOM 1578 C C . THR A 1 224 ? 52.687 -37.474 -5.065 1.00 115.81 ? 255 THR A C 1 ATOM 1579 O O . THR A 1 224 ? 51.562 -36.973 -4.953 1.00 108.98 ? 255 THR A O 1 ATOM 1580 C CB . THR A 1 224 ? 54.374 -35.647 -4.822 1.00 110.75 ? 255 THR A CB 1 ATOM 1581 O OG1 . THR A 1 224 ? 53.611 -34.447 -4.956 1.00 113.97 ? 255 THR A OG1 1 ATOM 1582 C CG2 . THR A 1 224 ? 55.843 -35.362 -5.137 1.00 105.49 ? 255 THR A CG2 1 ATOM 1583 N N . TRP A 1 225 ? 53.008 -38.679 -4.603 1.00 112.15 ? 256 TRP A N 1 ATOM 1584 C CA . TRP A 1 225 ? 52.039 -39.527 -3.936 1.00 107.38 ? 256 TRP A CA 1 ATOM 1585 C C . TRP A 1 225 ? 52.314 -39.564 -2.454 1.00 102.09 ? 256 TRP A C 1 ATOM 1586 O O . TRP A 1 225 ? 53.450 -39.774 -2.035 1.00 102.11 ? 256 TRP A O 1 ATOM 1587 C CB . TRP A 1 225 ? 52.127 -40.940 -4.480 1.00 107.47 ? 256 TRP A CB 1 ATOM 1588 C CG . TRP A 1 225 ? 51.747 -41.061 -5.903 1.00 109.77 ? 256 TRP A CG 1 ATOM 1589 C CD1 . TRP A 1 225 ? 52.462 -40.643 -6.979 1.00 114.46 ? 256 TRP A CD1 1 ATOM 1590 C CD2 . TRP A 1 225 ? 50.560 -41.661 -6.417 1.00 115.97 ? 256 TRP A CD2 1 ATOM 1591 N NE1 . TRP A 1 225 ? 51.792 -40.939 -8.137 1.00 115.79 ? 256 TRP A NE1 1 ATOM 1592 C CE2 . TRP A 1 225 ? 50.618 -41.567 -7.818 1.00 118.55 ? 256 TRP A CE2 1 ATOM 1593 C CE3 . TRP A 1 225 ? 49.448 -42.271 -5.827 1.00 115.95 ? 256 TRP A CE3 1 ATOM 1594 C CZ2 . TRP A 1 225 ? 49.610 -42.060 -8.641 1.00 122.29 ? 256 TRP A CZ2 1 ATOM 1595 C CZ3 . TRP A 1 225 ? 48.449 -42.755 -6.642 1.00 112.59 ? 256 TRP A CZ3 1 ATOM 1596 C CH2 . TRP A 1 225 ? 48.535 -42.648 -8.034 1.00 114.87 ? 256 TRP A CH2 1 ATOM 1597 N N . ILE A 1 226 ? 51.274 -39.357 -1.661 1.00 97.90 ? 257 ILE A N 1 ATOM 1598 C CA . ILE A 1 226 ? 51.400 -39.476 -0.220 1.00 99.34 ? 257 ILE A CA 1 ATOM 1599 C C . ILE A 1 226 ? 50.524 -40.627 0.253 1.00 102.78 ? 257 ILE A C 1 ATOM 1600 O O . ILE A 1 226 ? 49.444 -40.864 -0.288 1.00 105.71 ? 257 ILE A O 1 ATOM 1601 C CB . ILE A 1 226 ? 51.030 -38.178 0.497 1.00 100.37 ? 257 ILE A CB 1 ATOM 1602 C CG1 . ILE A 1 226 ? 51.656 -36.994 -0.228 1.00 99.81 ? 257 ILE A CG1 1 ATOM 1603 C CG2 . ILE A 1 226 ? 51.502 -38.214 1.939 1.00 97.43 ? 257 ILE A CG2 1 ATOM 1604 C CD1 . ILE A 1 226 ? 51.142 -35.674 0.237 1.00 99.92 ? 257 ILE A CD1 1 ATOM 1605 N N . VAL A 1 227 ? 50.984 -41.320 1.287 1.00 100.05 ? 258 VAL A N 1 ATOM 1606 C CA . VAL A 1 227 ? 50.539 -42.673 1.557 1.00 95.65 ? 258 VAL A CA 1 ATOM 1607 C C . VAL A 1 227 ? 50.687 -43.051 3.035 1.00 101.97 ? 258 VAL A C 1 ATOM 1608 O O . VAL A 1 227 ? 51.699 -42.741 3.661 1.00 103.24 ? 258 VAL A O 1 ATOM 1609 C CB . VAL A 1 227 ? 51.365 -43.623 0.688 1.00 92.24 ? 258 VAL A CB 1 ATOM 1610 C CG1 . VAL A 1 227 ? 51.984 -44.730 1.516 1.00 96.13 ? 258 VAL A CG1 1 ATOM 1611 C CG2 . VAL A 1 227 ? 50.537 -44.147 -0.459 1.00 97.01 ? 258 VAL A CG2 1 ATOM 1612 N N . PRO A 1 228 ? 49.679 -43.743 3.590 1.00 99.36 ? 259 PRO A N 1 ATOM 1613 C CA . PRO A 1 228 ? 49.573 -44.114 5.007 1.00 98.61 ? 259 PRO A CA 1 ATOM 1614 C C . PRO A 1 228 ? 50.688 -45.045 5.487 1.00 99.77 ? 259 PRO A C 1 ATOM 1615 O O . PRO A 1 228 ? 51.391 -45.663 4.691 1.00 96.66 ? 259 PRO A O 1 ATOM 1616 C CB . PRO A 1 228 ? 48.250 -44.867 5.075 1.00 96.36 ? 259 PRO A CB 1 ATOM 1617 C CG . PRO A 1 228 ? 47.584 -44.625 3.789 1.00 99.93 ? 259 PRO A CG 1 ATOM 1618 C CD . PRO A 1 228 ? 48.625 -44.372 2.789 1.00 97.87 ? 259 PRO A CD 1 ATOM 1619 N N . SER A 1 229 ? 50.820 -45.162 6.802 1.00 99.36 ? 260 SER A N 1 ATOM 1620 C CA . SER A 1 229 ? 51.946 -45.872 7.387 1.00 100.19 ? 260 SER A CA 1 ATOM 1621 C C . SER A 1 229 ? 52.038 -47.322 6.964 1.00 99.52 ? 260 SER A C 1 ATOM 1622 O O . SER A 1 229 ? 53.125 -47.876 6.913 1.00 101.81 ? 260 SER A O 1 ATOM 1623 C CB . SER A 1 229 ? 51.893 -45.802 8.911 1.00 103.52 ? 260 SER A CB 1 ATOM 1624 O OG . SER A 1 229 ? 52.874 -46.649 9.489 1.00 103.53 ? 260 SER A OG 1 ATOM 1625 N N . LEU A 1 230 ? 50.898 -47.940 6.687 1.00 103.59 ? 261 LEU A N 1 ATOM 1626 C CA . LEU A 1 230 ? 50.856 -49.371 6.402 1.00 102.14 ? 261 LEU A CA 1 ATOM 1627 C C . LEU A 1 230 ? 51.267 -49.703 4.976 1.00 101.74 ? 261 LEU A C 1 ATOM 1628 O O . LEU A 1 230 ? 51.429 -50.872 4.645 1.00 107.90 ? 261 LEU A O 1 ATOM 1629 C CB . LEU A 1 230 ? 49.454 -49.928 6.641 1.00 100.70 ? 261 LEU A CB 1 ATOM 1630 C CG . LEU A 1 230 ? 48.485 -49.682 5.485 1.00 96.38 ? 261 LEU A CG 1 ATOM 1631 C CD1 . LEU A 1 230 ? 47.240 -50.521 5.641 1.00 103.35 ? 261 LEU A CD1 1 ATOM 1632 C CD2 . LEU A 1 230 ? 48.126 -48.211 5.407 1.00 98.47 ? 261 LEU A CD2 1 ATOM 1633 N N . VAL A 1 231 ? 51.403 -48.697 4.120 1.00 98.98 ? 262 VAL A N 1 ATOM 1634 C CA . VAL A 1 231 ? 51.833 -48.957 2.753 1.00 95.59 ? 262 VAL A CA 1 ATOM 1635 C C . VAL A 1 231 ? 53.346 -48.930 2.702 1.00 98.79 ? 262 VAL A C 1 ATOM 1636 O O . VAL A 1 231 ? 53.958 -49.510 1.817 1.00 100.20 ? 262 VAL A O 1 ATOM 1637 C CB . VAL A 1 231 ? 51.274 -47.943 1.762 1.00 95.32 ? 262 VAL A CB 1 ATOM 1638 C CG1 . VAL A 1 231 ? 51.864 -48.177 0.395 1.00 91.58 ? 262 VAL A CG1 1 ATOM 1639 C CG2 . VAL A 1 231 ? 49.772 -48.038 1.704 1.00 96.72 ? 262 VAL A CG2 1 ATOM 1640 N N . ALA A 1 232 ? 53.948 -48.239 3.662 1.00 106.89 ? 263 ALA A N 1 ATOM 1641 C CA . ALA A 1 232 ? 55.390 -48.290 3.851 1.00 102.59 ? 263 ALA A CA 1 ATOM 1642 C C . ALA A 1 232 ? 55.732 -49.656 4.422 1.00 102.48 ? 263 ALA A C 1 ATOM 1643 O O . ALA A 1 232 ? 56.673 -50.309 3.985 1.00 110.66 ? 263 ALA A O 1 ATOM 1644 C CB . ALA A 1 232 ? 55.843 -47.183 4.797 1.00 96.39 ? 263 ALA A CB 1 ATOM 1645 N N . GLY A 1 233 ? 54.941 -50.088 5.395 1.00 100.23 ? 264 GLY A N 1 ATOM 1646 C CA . GLY A 1 233 ? 55.156 -51.361 6.050 1.00 107.05 ? 264 GLY A CA 1 ATOM 1647 C C . GLY A 1 233 ? 56.538 -51.421 6.655 1.00 112.27 ? 264 GLY A C 1 ATOM 1648 O O . GLY A 1 233 ? 57.004 -50.435 7.229 1.00 113.95 ? 264 GLY A O 1 ATOM 1649 N N . ASP A 1 234 ? 57.186 -52.579 6.538 1.00 114.27 ? 265 ASP A N 1 ATOM 1650 C CA . ASP A 1 234 ? 58.594 -52.704 6.890 1.00 118.38 ? 265 ASP A CA 1 ATOM 1651 C C . ASP A 1 234 ? 59.395 -51.879 5.899 1.00 117.10 ? 265 ASP A C 1 ATOM 1652 O O . ASP A 1 234 ? 59.407 -52.171 4.703 1.00 115.45 ? 265 ASP A O 1 ATOM 1653 C CB . ASP A 1 234 ? 59.048 -54.165 6.830 1.00 121.89 ? 265 ASP A CB 1 ATOM 1654 C CG . ASP A 1 234 ? 60.520 -54.337 7.197 1.00 127.33 ? 265 ASP A CG 1 ATOM 1655 O OD1 . ASP A 1 234 ? 61.056 -53.479 7.939 1.00 126.02 ? 265 ASP A OD1 1 ATOM 1656 O OD2 . ASP A 1 234 ? 61.138 -55.330 6.748 1.00 126.47 ? 265 ASP A OD2 1 ATOM 1657 N N . THR A 1 235 ? 60.053 -50.839 6.395 1.00 116.66 ? 266 THR A N 1 ATOM 1658 C CA . THR A 1 235 ? 60.774 -49.920 5.524 1.00 116.65 ? 266 THR A CA 1 ATOM 1659 C C . THR A 1 235 ? 61.948 -50.596 4.824 1.00 118.17 ? 266 THR A C 1 ATOM 1660 O O . THR A 1 235 ? 62.503 -50.059 3.867 1.00 117.99 ? 266 THR A O 1 ATOM 1661 C CB . THR A 1 235 ? 61.266 -48.698 6.302 1.00 114.84 ? 266 THR A CB 1 ATOM 1662 O OG1 . THR A 1 235 ? 61.550 -49.080 7.655 1.00 120.84 ? 266 THR A OG1 1 ATOM 1663 C CG2 . THR A 1 235 ? 60.199 -47.628 6.305 1.00 107.32 ? 266 THR A CG2 1 ATOM 1664 N N . ASP A 1 236 ? 62.313 -51.782 5.300 1.00 119.58 ? 267 ASP A N 1 ATOM 1665 C CA . ASP A 1 236 ? 63.422 -52.535 4.726 1.00 120.13 ? 267 ASP A CA 1 ATOM 1666 C C . ASP A 1 236 ? 63.024 -53.284 3.464 1.00 116.34 ? 267 ASP A C 1 ATOM 1667 O O . ASP A 1 236 ? 63.871 -53.818 2.756 1.00 119.82 ? 267 ASP A O 1 ATOM 1668 C CB . ASP A 1 236 ? 63.987 -53.516 5.753 1.00 127.20 ? 267 ASP A CB 1 ATOM 1669 C CG . ASP A 1 236 ? 64.834 -52.826 6.808 1.00 137.48 ? 267 ASP A CG 1 ATOM 1670 O OD1 . ASP A 1 236 ? 65.415 -51.761 6.496 1.00 134.33 ? 267 ASP A OD1 1 ATOM 1671 O OD2 . ASP A 1 236 ? 64.923 -53.348 7.944 1.00 144.48 ? 267 ASP A OD2 1 ATOM 1672 N N . THR A 1 237 ? 61.730 -53.329 3.186 1.00 114.58 ? 268 THR A N 1 ATOM 1673 C CA . THR A 1 237 ? 61.239 -54.020 2.006 1.00 111.84 ? 268 THR A CA 1 ATOM 1674 C C . THR A 1 237 ? 60.572 -53.057 1.039 1.00 111.95 ? 268 THR A C 1 ATOM 1675 O O . THR A 1 237 ? 59.429 -52.652 1.247 1.00 113.05 ? 268 THR A O 1 ATOM 1676 C CB . THR A 1 237 ? 60.222 -55.093 2.378 1.00 110.05 ? 268 THR A CB 1 ATOM 1677 O OG1 . THR A 1 237 ? 60.844 -56.073 3.219 1.00 113.88 ? 268 THR A OG1 1 ATOM 1678 C CG2 . THR A 1 237 ? 59.683 -55.753 1.119 1.00 106.85 ? 268 THR A CG2 1 ATOM 1679 N N . VAL A 1 238 ? 61.280 -52.697 -0.023 1.00 109.38 ? 269 VAL A N 1 ATOM 1680 C CA . VAL A 1 238 ? 60.751 -51.728 -0.970 1.00 108.79 ? 269 VAL A CA 1 ATOM 1681 C C . VAL A 1 238 ? 60.512 -52.316 -2.360 1.00 110.42 ? 269 VAL A C 1 ATOM 1682 O O . VAL A 1 238 ? 61.459 -52.601 -3.092 1.00 116.32 ? 269 VAL A O 1 ATOM 1683 C CB . VAL A 1 238 ? 61.664 -50.491 -1.075 1.00 108.57 ? 269 VAL A CB 1 ATOM 1684 C CG1 . VAL A 1 238 ? 61.002 -49.416 -1.916 1.00 108.92 ? 269 VAL A CG1 1 ATOM 1685 C CG2 . VAL A 1 238 ? 61.992 -49.961 0.312 1.00 107.26 ? 269 VAL A CG2 1 ATOM 1686 N N . PRO A 1 239 ? 59.234 -52.503 -2.715 1.00 108.16 ? 270 PRO A N 1 ATOM 1687 C CA . PRO A 1 239 ? 58.757 -52.886 -4.046 1.00 114.27 ? 270 PRO A CA 1 ATOM 1688 C C . PRO A 1 239 ? 59.473 -52.150 -5.176 1.00 118.14 ? 270 PRO A C 1 ATOM 1689 O O . PRO A 1 239 ? 59.829 -50.982 -5.037 1.00 121.32 ? 270 PRO A O 1 ATOM 1690 C CB . PRO A 1 239 ? 57.292 -52.449 -4.015 1.00 110.65 ? 270 PRO A CB 1 ATOM 1691 C CG . PRO A 1 239 ? 56.892 -52.607 -2.600 1.00 105.97 ? 270 PRO A CG 1 ATOM 1692 C CD . PRO A 1 239 ? 58.127 -52.417 -1.747 1.00 107.76 ? 270 PRO A CD 1 ATOM 1693 N N . SER A 1 240 ? 59.672 -52.833 -6.295 1.00 118.30 ? 271 SER A N 1 ATOM 1694 C CA . SER A 1 240 ? 60.276 -52.204 -7.456 1.00 121.31 ? 271 SER A CA 1 ATOM 1695 C C . SER A 1 240 ? 59.373 -51.082 -7.958 1.00 121.50 ? 271 SER A C 1 ATOM 1696 O O . SER A 1 240 ? 59.845 -50.042 -8.420 1.00 123.93 ? 271 SER A O 1 ATOM 1697 C CB . SER A 1 240 ? 60.490 -53.238 -8.566 1.00 124.87 ? 271 SER A CB 1 ATOM 1698 O OG . SER A 1 240 ? 61.076 -54.432 -8.062 1.00 132.09 ? 271 SER A OG 1 ATOM 1699 N N . GLU A 1 241 ? 58.068 -51.296 -7.847 1.00 118.47 ? 272 GLU A N 1 ATOM 1700 C CA . GLU A 1 241 ? 57.093 -50.413 -8.475 1.00 122.29 ? 272 GLU A CA 1 ATOM 1701 C C . GLU A 1 241 ? 56.818 -49.140 -7.675 1.00 120.85 ? 272 GLU A C 1 ATOM 1702 O O . GLU A 1 241 ? 56.154 -48.223 -8.161 1.00 121.68 ? 272 GLU A O 1 ATOM 1703 C CB . GLU A 1 241 ? 55.788 -51.169 -8.774 1.00 121.62 ? 272 GLU A CB 1 ATOM 1704 C CG . GLU A 1 241 ? 55.434 -52.275 -7.770 1.00 124.97 ? 272 GLU A CG 1 ATOM 1705 C CD . GLU A 1 241 ? 55.999 -53.661 -8.133 1.00 129.81 ? 272 GLU A CD 1 ATOM 1706 O OE1 . GLU A 1 241 ? 57.239 -53.816 -8.223 1.00 130.22 ? 272 GLU A OE1 1 ATOM 1707 O OE2 . GLU A 1 241 ? 55.193 -54.607 -8.303 1.00 127.60 ? 272 GLU A OE2 1 ATOM 1708 N N . PHE A 1 242 ? 57.329 -49.084 -6.453 1.00 116.71 ? 273 PHE A N 1 ATOM 1709 C CA . PHE A 1 242 ? 57.166 -47.896 -5.627 1.00 113.03 ? 273 PHE A CA 1 ATOM 1710 C C . PHE A 1 242 ? 57.932 -46.736 -6.240 1.00 117.02 ? 273 PHE A C 1 ATOM 1711 O O . PHE A 1 242 ? 59.149 -46.810 -6.398 1.00 118.99 ? 273 PHE A O 1 ATOM 1712 C CB . PHE A 1 242 ? 57.663 -48.170 -4.210 1.00 111.31 ? 273 PHE A CB 1 ATOM 1713 C CG . PHE A 1 242 ? 56.620 -48.763 -3.311 1.00 111.49 ? 273 PHE A CG 1 ATOM 1714 C CD1 . PHE A 1 242 ? 55.454 -49.289 -3.835 1.00 112.71 ? 273 PHE A CD1 1 ATOM 1715 C CD2 . PHE A 1 242 ? 56.811 -48.811 -1.943 1.00 105.42 ? 273 PHE A CD2 1 ATOM 1716 C CE1 . PHE A 1 242 ? 54.495 -49.837 -3.012 1.00 103.47 ? 273 PHE A CE1 1 ATOM 1717 C CE2 . PHE A 1 242 ? 55.855 -49.363 -1.118 1.00 99.08 ? 273 PHE A CE2 1 ATOM 1718 C CZ . PHE A 1 242 ? 54.698 -49.875 -1.655 1.00 99.29 ? 273 PHE A CZ 1 ATOM 1719 N N . PRO A 1 243 ? 57.222 -45.650 -6.582 1.00 118.50 ? 274 PRO A N 1 ATOM 1720 C CA . PRO A 1 243 ? 57.871 -44.516 -7.246 1.00 114.48 ? 274 PRO A CA 1 ATOM 1721 C C . PRO A 1 243 ? 58.823 -43.823 -6.291 1.00 114.43 ? 274 PRO A C 1 ATOM 1722 O O . PRO A 1 243 ? 58.445 -43.596 -5.141 1.00 110.45 ? 274 PRO A O 1 ATOM 1723 C CB . PRO A 1 243 ? 56.704 -43.564 -7.558 1.00 112.99 ? 274 PRO A CB 1 ATOM 1724 C CG . PRO A 1 243 ? 55.450 -44.316 -7.244 1.00 118.62 ? 274 PRO A CG 1 ATOM 1725 C CD . PRO A 1 243 ? 55.826 -45.354 -6.229 1.00 117.34 ? 274 PRO A CD 1 ATOM 1726 N N . THR A 1 244 ? 60.033 -43.500 -6.745 1.00 118.99 ? 275 THR A N 1 ATOM 1727 C CA . THR A 1 244 ? 60.915 -42.646 -5.953 1.00 116.53 ? 275 THR A CA 1 ATOM 1728 C C . THR A 1 244 ? 60.213 -41.297 -5.782 1.00 112.69 ? 275 THR A C 1 ATOM 1729 O O . THR A 1 244 ? 59.579 -40.796 -6.718 1.00 106.82 ? 275 THR A O 1 ATOM 1730 C CB . THR A 1 244 ? 62.311 -42.470 -6.597 1.00 115.90 ? 275 THR A CB 1 ATOM 1731 O OG1 . THR A 1 244 ? 62.203 -41.656 -7.771 1.00 122.69 ? 275 THR A OG1 1 ATOM 1732 C CG2 . THR A 1 244 ? 62.910 -43.826 -6.968 1.00 115.59 ? 275 THR A CG2 1 ATOM 1733 N N . GLY A 1 245 ? 60.301 -40.730 -4.583 1.00 106.83 ? 276 GLY A N 1 ATOM 1734 C CA . GLY A 1 245 ? 59.537 -39.542 -4.253 1.00 105.53 ? 276 GLY A CA 1 ATOM 1735 C C . GLY A 1 245 ? 58.186 -39.919 -3.680 1.00 108.01 ? 276 GLY A C 1 ATOM 1736 O O . GLY A 1 245 ? 57.185 -39.218 -3.842 1.00 109.53 ? 276 GLY A O 1 ATOM 1737 N N . LEU A 1 246 ? 58.152 -41.062 -3.016 1.00 110.17 ? 277 LEU A N 1 ATOM 1738 C CA . LEU A 1 246 ? 56.949 -41.487 -2.342 1.00 105.37 ? 277 LEU A CA 1 ATOM 1739 C C . LEU A 1 246 ? 57.033 -40.933 -0.939 1.00 103.97 ? 277 LEU A C 1 ATOM 1740 O O . LEU A 1 246 ? 57.960 -41.253 -0.193 1.00 103.16 ? 277 LEU A O 1 ATOM 1741 C CB . LEU A 1 246 ? 56.874 -43.012 -2.312 1.00 105.69 ? 277 LEU A CB 1 ATOM 1742 C CG . LEU A 1 246 ? 55.594 -43.634 -1.756 1.00 100.22 ? 277 LEU A CG 1 ATOM 1743 C CD1 . LEU A 1 246 ? 54.412 -43.270 -2.617 1.00 99.16 ? 277 LEU A CD1 1 ATOM 1744 C CD2 . LEU A 1 246 ? 55.745 -45.132 -1.675 1.00 98.24 ? 277 LEU A CD2 1 ATOM 1745 N N . ILE A 1 247 ? 56.089 -40.071 -0.586 1.00 101.98 ? 278 ILE A N 1 ATOM 1746 C CA . ILE A 1 247 ? 56.028 -39.575 0.776 1.00 102.61 ? 278 ILE A CA 1 ATOM 1747 C C . ILE A 1 247 ? 55.107 -40.473 1.565 1.00 99.93 ? 278 ILE A C 1 ATOM 1748 O O . ILE A 1 247 ? 54.061 -40.869 1.078 1.00 101.40 ? 278 ILE A O 1 ATOM 1749 C CB . ILE A 1 247 ? 55.479 -38.160 0.852 1.00 100.43 ? 278 ILE A CB 1 ATOM 1750 C CG1 . ILE A 1 247 ? 56.139 -37.276 -0.209 1.00 106.25 ? 278 ILE A CG1 1 ATOM 1751 C CG2 . ILE A 1 247 ? 55.688 -37.623 2.251 1.00 94.70 ? 278 ILE A CG2 1 ATOM 1752 C CD1 . ILE A 1 247 ? 55.237 -36.155 -0.732 1.00 103.66 ? 278 ILE A CD1 1 ATOM 1753 N N . SER A 1 248 ? 55.495 -40.792 2.788 1.00 99.80 ? 279 SER A N 1 ATOM 1754 C CA . SER A 1 248 ? 54.684 -41.645 3.623 1.00 98.79 ? 279 SER A CA 1 ATOM 1755 C C . SER A 1 248 ? 54.853 -41.263 5.081 1.00 104.30 ? 279 SER A C 1 ATOM 1756 O O . SER A 1 248 ? 55.923 -40.817 5.491 1.00 103.14 ? 279 SER A O 1 ATOM 1757 C CB . SER A 1 248 ? 55.088 -43.098 3.424 1.00 98.60 ? 279 SER A CB 1 ATOM 1758 O OG . SER A 1 248 ? 54.483 -43.918 4.406 1.00 101.15 ? 279 SER A OG 1 ATOM 1759 N N . VAL A 1 249 ? 53.787 -41.420 5.859 1.00 104.48 ? 280 VAL A N 1 ATOM 1760 C CA . VAL A 1 249 ? 53.883 -41.311 7.302 1.00 100.51 ? 280 VAL A CA 1 ATOM 1761 C C . VAL A 1 249 ? 54.244 -42.670 7.843 1.00 101.05 ? 280 VAL A C 1 ATOM 1762 O O . VAL A 1 249 ? 53.767 -43.671 7.335 1.00 109.09 ? 280 VAL A O 1 ATOM 1763 C CB . VAL A 1 249 ? 52.555 -40.958 7.905 1.00 98.30 ? 280 VAL A CB 1 ATOM 1764 C CG1 . VAL A 1 249 ? 52.663 -41.039 9.411 1.00 98.69 ? 280 VAL A CG1 1 ATOM 1765 C CG2 . VAL A 1 249 ? 52.126 -39.579 7.432 1.00 101.78 ? 280 VAL A CG2 1 ATOM 1766 N N . SER A 1 250 ? 55.089 -42.720 8.860 1.00 96.74 ? 281 SER A N 1 ATOM 1767 C CA . SER A 1 250 ? 55.439 -43.999 9.457 1.00 102.15 ? 281 SER A CA 1 ATOM 1768 C C . SER A 1 250 ? 55.568 -43.859 10.953 1.00 108.82 ? 281 SER A C 1 ATOM 1769 O O . SER A 1 250 ? 55.920 -42.800 11.460 1.00 110.50 ? 281 SER A O 1 ATOM 1770 C CB . SER A 1 250 ? 56.729 -44.552 8.867 1.00 98.71 ? 281 SER A CB 1 ATOM 1771 N N . TYR A 1 251 ? 55.260 -44.934 11.662 1.00 115.75 ? 282 TYR A N 1 ATOM 1772 C CA . TYR A 1 251 ? 55.562 -45.004 13.077 1.00 119.54 ? 282 TYR A CA 1 ATOM 1773 C C . TYR A 1 251 ? 57.091 -44.995 13.195 1.00 124.37 ? 282 TYR A C 1 ATOM 1774 O O . TYR A 1 251 ? 57.788 -45.329 12.233 1.00 125.28 ? 282 TYR A O 1 ATOM 1775 C CB . TYR A 1 251 ? 54.944 -46.269 13.666 1.00 122.64 ? 282 TYR A CB 1 ATOM 1776 C CG . TYR A 1 251 ? 54.735 -46.211 15.160 1.00 125.95 ? 282 TYR A CG 1 ATOM 1777 C CD1 . TYR A 1 251 ? 54.251 -45.058 15.772 1.00 120.38 ? 282 TYR A CD1 1 ATOM 1778 C CD2 . TYR A 1 251 ? 55.005 -47.318 15.961 1.00 123.39 ? 282 TYR A CD2 1 ATOM 1779 C CE1 . TYR A 1 251 ? 54.057 -45.009 17.145 1.00 120.78 ? 282 TYR A CE1 1 ATOM 1780 C CE2 . TYR A 1 251 ? 54.818 -47.278 17.329 1.00 114.99 ? 282 TYR A CE2 1 ATOM 1781 C CZ . TYR A 1 251 ? 54.342 -46.125 17.916 1.00 118.94 ? 282 TYR A CZ 1 ATOM 1782 O OH . TYR A 1 251 ? 54.158 -46.096 19.281 1.00 121.13 ? 282 TYR A OH 1 ATOM 1783 N N . ASP A 1 252 ? 57.621 -44.598 14.349 1.00 121.55 ? 283 ASP A N 1 ATOM 1784 C CA . ASP A 1 252 ? 59.058 -44.325 14.452 1.00 127.07 ? 283 ASP A CA 1 ATOM 1785 C C . ASP A 1 252 ? 59.880 -45.524 14.900 1.00 133.34 ? 283 ASP A C 1 ATOM 1786 O O . ASP A 1 252 ? 60.016 -45.777 16.094 1.00 135.39 ? 283 ASP A O 1 ATOM 1787 C CB . ASP A 1 252 ? 59.322 -43.143 15.392 1.00 130.52 ? 283 ASP A CB 1 ATOM 1788 C CG . ASP A 1 252 ? 60.813 -42.885 15.611 1.00 135.96 ? 283 ASP A CG 1 ATOM 1789 O OD1 . ASP A 1 252 ? 61.647 -43.530 14.935 1.00 132.73 ? 283 ASP A OD1 1 ATOM 1790 O OD2 . ASP A 1 252 ? 61.148 -42.035 16.466 1.00 137.40 ? 283 ASP A OD2 1 ATOM 1791 N N . GLU A 1 253 ? 60.462 -46.243 13.947 1.00 135.27 ? 284 GLU A N 1 ATOM 1792 C CA . GLU A 1 253 ? 61.207 -47.452 14.287 1.00 139.29 ? 284 GLU A CA 1 ATOM 1793 C C . GLU A 1 253 ? 62.700 -47.146 14.509 1.00 141.91 ? 284 GLU A C 1 ATOM 1794 O O . GLU A 1 253 ? 63.532 -48.059 14.559 1.00 143.91 ? 284 GLU A O 1 ATOM 1795 C CB . GLU A 1 253 ? 60.987 -48.542 13.218 1.00 137.53 ? 284 GLU A CB 1 ATOM 1796 C CG . GLU A 1 253 ? 60.982 -49.990 13.738 1.00 134.51 ? 284 GLU A CG 1 ATOM 1797 C CD . GLU A 1 253 ? 60.880 -51.007 12.600 1.00 141.34 ? 284 GLU A CD 1 ATOM 1798 O OE1 . GLU A 1 253 ? 60.064 -50.754 11.673 1.00 134.03 ? 284 GLU A OE1 1 ATOM 1799 O OE2 . GLU A 1 253 ? 61.631 -52.021 12.598 1.00 132.17 ? 284 GLU A OE2 1 ATOM 1800 N N . TRP A 1 254 ? 63.034 -45.864 14.660 1.00 139.40 ? 285 TRP A N 1 ATOM 1801 C CA . TRP A 1 254 ? 64.430 -45.459 14.860 1.00 138.99 ? 285 TRP A CA 1 ATOM 1802 C C . TRP A 1 254 ? 64.777 -45.225 16.337 1.00 139.23 ? 285 TRP A C 1 ATOM 1803 O O . TRP A 1 254 ? 65.538 -45.992 16.936 1.00 137.62 ? 285 TRP A O 1 ATOM 1804 C CB . TRP A 1 254 ? 64.766 -44.226 14.014 1.00 130.48 ? 285 TRP A CB 1 ATOM 1805 N N . ASP A 1 255 ? 64.213 -44.172 16.921 1.00 137.00 ? 286 ASP A N 1 ATOM 1806 C CA . ASP A 1 255 ? 64.432 -43.869 18.335 1.00 136.08 ? 286 ASP A CA 1 ATOM 1807 C C . ASP A 1 255 ? 63.593 -44.773 19.247 1.00 134.46 ? 286 ASP A C 1 ATOM 1808 O O . ASP A 1 255 ? 63.650 -44.665 20.474 1.00 131.88 ? 286 ASP A O 1 ATOM 1809 C CB . ASP A 1 255 ? 64.134 -42.394 18.619 1.00 135.68 ? 286 ASP A CB 1 ATOM 1810 N N . TYR A 1 256 ? 62.819 -45.668 18.640 1.00 132.97 ? 287 TYR A N 1 ATOM 1811 C CA . TYR A 1 256 ? 61.905 -46.521 19.387 1.00 123.28 ? 287 TYR A CA 1 ATOM 1812 C C . TYR A 1 256 ? 62.102 -47.966 18.995 1.00 122.48 ? 287 TYR A C 1 ATOM 1813 O O . TYR A 1 256 ? 61.388 -48.488 18.140 1.00 117.78 ? 287 TYR A O 1 ATOM 1814 C CB . TYR A 1 256 ? 60.470 -46.117 19.100 1.00 116.59 ? 287 TYR A CB 1 ATOM 1815 C CG . TYR A 1 256 ? 59.477 -46.518 20.160 1.00 112.03 ? 287 TYR A CG 1 ATOM 1816 C CD1 . TYR A 1 256 ? 59.808 -46.478 21.505 1.00 112.86 ? 287 TYR A CD1 1 ATOM 1817 C CD2 . TYR A 1 256 ? 58.188 -46.899 19.814 1.00 115.94 ? 287 TYR A CD2 1 ATOM 1818 C CE1 . TYR A 1 256 ? 58.883 -46.834 22.480 1.00 114.33 ? 287 TYR A CE1 1 ATOM 1819 C CE2 . TYR A 1 256 ? 57.256 -47.249 20.776 1.00 114.90 ? 287 TYR A CE2 1 ATOM 1820 C CZ . TYR A 1 256 ? 57.607 -47.215 22.107 1.00 113.31 ? 287 TYR A CZ 1 ATOM 1821 O OH . TYR A 1 256 ? 56.676 -47.562 23.063 1.00 111.69 ? 287 TYR A OH 1 ATOM 1822 N N . GLY A 1 257 ? 63.081 -48.607 19.622 1.00 126.76 ? 288 GLY A N 1 ATOM 1823 C CA . GLY A 1 257 ? 63.374 -50.002 19.347 1.00 123.76 ? 288 GLY A CA 1 ATOM 1824 C C . GLY A 1 257 ? 62.300 -50.944 19.859 1.00 109.42 ? 288 GLY A C 1 ATOM 1825 O O . GLY A 1 257 ? 61.443 -50.548 20.648 1.00 107.20 ? 288 GLY A O 1 ATOM 1826 N N . LEU A 1 258 ? 62.354 -52.194 19.410 1.00 103.48 ? 289 LEU A N 1 ATOM 1827 C CA . LEU A 1 258 ? 61.386 -53.192 19.837 1.00 103.42 ? 289 LEU A CA 1 ATOM 1828 C C . LEU A 1 258 ? 61.375 -53.338 21.359 1.00 103.86 ? 289 LEU A C 1 ATOM 1829 O O . LEU A 1 258 ? 60.335 -53.133 21.990 1.00 105.37 ? 289 LEU A O 1 ATOM 1830 C CB . LEU A 1 258 ? 61.653 -54.539 19.157 1.00 104.21 ? 289 LEU A CB 1 ATOM 1831 C CG . LEU A 1 258 ? 60.600 -55.644 19.230 1.00 90.01 ? 289 LEU A CG 1 ATOM 1832 C CD1 . LEU A 1 258 ? 59.237 -55.127 18.850 1.00 97.63 ? 289 LEU A CD1 1 ATOM 1833 C CD2 . LEU A 1 258 ? 60.999 -56.750 18.304 1.00 96.94 ? 289 LEU A CD2 1 ATOM 1834 N N . PRO A 1 259 ? 62.529 -53.678 21.960 1.00 101.49 ? 290 PRO A N 1 ATOM 1835 C CA . PRO A 1 259 ? 62.530 -53.898 23.410 1.00 99.90 ? 290 PRO A CA 1 ATOM 1836 C C . PRO A 1 259 ? 61.876 -52.770 24.218 1.00 101.42 ? 290 PRO A C 1 ATOM 1837 O O . PRO A 1 259 ? 61.417 -53.025 25.331 1.00 100.40 ? 290 PRO A O 1 ATOM 1838 C CB . PRO A 1 259 ? 64.016 -54.021 23.731 1.00 94.26 ? 290 PRO A CB 1 ATOM 1839 C CG . PRO A 1 259 ? 64.599 -54.593 22.493 1.00 98.30 ? 290 PRO A CG 1 ATOM 1840 C CD . PRO A 1 259 ? 63.846 -53.964 21.365 1.00 98.41 ? 290 PRO A CD 1 ATOM 1841 N N . ALA A 1 260 ? 61.822 -51.559 23.666 1.00 99.41 ? 291 ALA A N 1 ATOM 1842 C CA . ALA A 1 260 ? 61.218 -50.419 24.357 1.00 98.60 ? 291 ALA A CA 1 ATOM 1843 C C . ALA A 1 260 ? 59.706 -50.470 24.307 1.00 104.32 ? 291 ALA A C 1 ATOM 1844 O O . ALA A 1 260 ? 59.018 -49.998 25.214 1.00 102.81 ? 291 ALA A O 1 ATOM 1845 C CB . ALA A 1 260 ? 61.683 -49.150 23.739 1.00 107.55 ? 291 ALA A CB 1 ATOM 1846 N N . ARG A 1 261 ? 59.198 -51.017 23.211 1.00 104.35 ? 292 ARG A N 1 ATOM 1847 C CA . ARG A 1 261 ? 57.778 -51.226 23.044 1.00 96.52 ? 292 ARG A CA 1 ATOM 1848 C C . ARG A 1 261 ? 57.354 -52.338 23.972 1.00 100.10 ? 292 ARG A C 1 ATOM 1849 O O . ARG A 1 261 ? 56.439 -52.160 24.767 1.00 104.12 ? 292 ARG A O 1 ATOM 1850 C CB . ARG A 1 261 ? 57.466 -51.584 21.604 1.00 89.78 ? 292 ARG A CB 1 ATOM 1851 C CG . ARG A 1 261 ? 58.034 -50.595 20.644 1.00 97.83 ? 292 ARG A CG 1 ATOM 1852 C CD . ARG A 1 261 ? 57.505 -50.793 19.255 1.00 102.15 ? 292 ARG A CD 1 ATOM 1853 N NE . ARG A 1 261 ? 58.047 -49.796 18.344 1.00 105.34 ? 292 ARG A NE 1 ATOM 1854 C CZ . ARG A 1 261 ? 57.524 -49.503 17.162 1.00 110.31 ? 292 ARG A CZ 1 ATOM 1855 N NH1 . ARG A 1 261 ? 56.433 -50.129 16.744 1.00 114.13 ? 292 ARG A NH1 1 ATOM 1856 N NH2 . ARG A 1 261 ? 58.087 -48.583 16.395 1.00 117.79 ? 292 ARG A NH2 1 ATOM 1857 N N . VAL A 1 262 ? 58.024 -53.484 23.884 1.00 96.60 ? 293 VAL A N 1 ATOM 1858 C CA . VAL A 1 262 ? 57.728 -54.594 24.782 1.00 94.48 ? 293 VAL A CA 1 ATOM 1859 C C . VAL A 1 262 ? 57.682 -54.111 26.229 1.00 97.75 ? 293 VAL A C 1 ATOM 1860 O O . VAL A 1 262 ? 56.751 -54.425 26.963 1.00 97.08 ? 293 VAL A O 1 ATOM 1861 C CB . VAL A 1 262 ? 58.746 -55.735 24.656 1.00 92.03 ? 293 VAL A CB 1 ATOM 1862 C CG1 . VAL A 1 262 ? 58.576 -56.706 25.798 1.00 92.01 ? 293 VAL A CG1 1 ATOM 1863 C CG2 . VAL A 1 262 ? 58.586 -56.443 23.333 1.00 88.89 ? 293 VAL A CG2 1 ATOM 1864 N N . ARG A 1 263 ? 58.681 -53.336 26.638 1.00 97.02 ? 294 ARG A N 1 ATOM 1865 C CA . ARG A 1 263 ? 58.658 -52.740 27.962 1.00 96.18 ? 294 ARG A CA 1 ATOM 1866 C C . ARG A 1 263 ? 57.362 -51.963 28.123 1.00 100.39 ? 294 ARG A C 1 ATOM 1867 O O . ARG A 1 263 ? 56.623 -52.150 29.085 1.00 101.06 ? 294 ARG A O 1 ATOM 1868 C CB . ARG A 1 263 ? 59.849 -51.810 28.152 1.00 98.37 ? 294 ARG A CB 1 ATOM 1869 C CG . ARG A 1 263 ? 59.809 -50.994 29.438 1.00 104.57 ? 294 ARG A CG 1 ATOM 1870 C CD . ARG A 1 263 ? 61.098 -50.205 29.650 1.00 109.88 ? 294 ARG A CD 1 ATOM 1871 N NE . ARG A 1 263 ? 62.251 -51.104 29.667 1.00 119.80 ? 294 ARG A NE 1 ATOM 1872 C CZ . ARG A 1 263 ? 63.207 -51.136 28.741 1.00 112.85 ? 294 ARG A CZ 1 ATOM 1873 N NH1 . ARG A 1 263 ? 63.182 -50.296 27.712 1.00 106.74 ? 294 ARG A NH1 1 ATOM 1874 N NH2 . ARG A 1 263 ? 64.195 -52.013 28.854 1.00 104.71 ? 294 ARG A NH2 1 ATOM 1875 N N . ASP A 1 264 ? 57.083 -51.094 27.162 1.00 98.55 ? 295 ASP A N 1 ATOM 1876 C CA . ASP A 1 264 ? 55.869 -50.292 27.200 1.00 100.20 ? 295 ASP A CA 1 ATOM 1877 C C . ASP A 1 264 ? 54.605 -51.145 27.187 1.00 102.83 ? 295 ASP A C 1 ATOM 1878 O O . ASP A 1 264 ? 53.635 -50.827 27.866 1.00 104.39 ? 295 ASP A O 1 ATOM 1879 C CB . ASP A 1 264 ? 55.847 -49.298 26.042 1.00 106.95 ? 295 ASP A CB 1 ATOM 1880 C CG . ASP A 1 264 ? 56.731 -48.089 26.293 1.00 114.77 ? 295 ASP A CG 1 ATOM 1881 O OD1 . ASP A 1 264 ? 57.625 -48.178 27.163 1.00 120.71 ? 295 ASP A OD1 1 ATOM 1882 O OD2 . ASP A 1 264 ? 56.531 -47.049 25.626 1.00 117.55 ? 295 ASP A OD2 1 ATOM 1883 N N . GLY A 1 265 ? 54.611 -52.222 26.412 1.00 101.00 ? 296 GLY A N 1 ATOM 1884 C CA . GLY A 1 265 ? 53.506 -53.161 26.421 1.00 99.35 ? 296 GLY A CA 1 ATOM 1885 C C . GLY A 1 265 ? 53.239 -53.679 27.824 1.00 99.07 ? 296 GLY A C 1 ATOM 1886 O O . GLY A 1 265 ? 52.153 -53.511 28.367 1.00 100.00 ? 296 GLY A O 1 ATOM 1887 N N . ILE A 1 266 ? 54.243 -54.300 28.424 1.00 98.54 ? 297 ILE A N 1 ATOM 1888 C CA . ILE A 1 266 ? 54.103 -54.832 29.771 1.00 100.49 ? 297 ILE A CA 1 ATOM 1889 C C . ILE A 1 266 ? 53.682 -53.739 30.737 1.00 100.14 ? 297 ILE A C 1 ATOM 1890 O O . ILE A 1 266 ? 52.951 -53.979 31.690 1.00 101.54 ? 297 ILE A O 1 ATOM 1891 C CB . ILE A 1 266 ? 55.416 -55.460 30.256 1.00 96.57 ? 297 ILE A CB 1 ATOM 1892 C CG1 . ILE A 1 266 ? 55.838 -56.565 29.292 1.00 94.78 ? 297 ILE A CG1 1 ATOM 1893 C CG2 . ILE A 1 266 ? 55.258 -55.994 31.661 1.00 97.16 ? 297 ILE A CG2 1 ATOM 1894 C CD1 . ILE A 1 266 ? 56.921 -57.439 29.806 1.00 94.59 ? 297 ILE A CD1 1 ATOM 1895 N N . ALA A 1 267 ? 54.149 -52.530 30.482 1.00 100.21 ? 298 ALA A N 1 ATOM 1896 C CA . ALA A 1 267 ? 53.851 -51.424 31.364 1.00 101.23 ? 298 ALA A CA 1 ATOM 1897 C C . ALA A 1 267 ? 52.371 -51.102 31.295 1.00 104.99 ? 298 ALA A C 1 ATOM 1898 O O . ALA A 1 267 ? 51.696 -51.041 32.317 1.00 110.97 ? 298 ALA A O 1 ATOM 1899 C CB . ALA A 1 267 ? 54.675 -50.229 30.982 1.00 106.30 ? 298 ALA A CB 1 ATOM 1900 N N . ILE A 1 268 ? 51.868 -50.906 30.083 1.00 104.04 ? 299 ILE A N 1 ATOM 1901 C CA . ILE A 1 268 ? 50.467 -50.572 29.887 1.00 102.69 ? 299 ILE A CA 1 ATOM 1902 C C . ILE A 1 268 ? 49.575 -51.504 30.676 1.00 106.23 ? 299 ILE A C 1 ATOM 1903 O O . ILE A 1 268 ? 48.734 -51.057 31.455 1.00 108.65 ? 299 ILE A O 1 ATOM 1904 C CB . ILE A 1 268 ? 50.070 -50.684 28.426 1.00 100.08 ? 299 ILE A CB 1 ATOM 1905 C CG1 . ILE A 1 268 ? 50.666 -49.527 27.634 1.00 100.52 ? 299 ILE A CG1 1 ATOM 1906 C CG2 . ILE A 1 268 ? 48.566 -50.679 28.301 1.00 101.90 ? 299 ILE A CG2 1 ATOM 1907 C CD1 . ILE A 1 268 ? 50.522 -49.684 26.144 1.00 102.95 ? 299 ILE A CD1 1 ATOM 1908 N N . ILE A 1 269 ? 49.763 -52.804 30.466 1.00 105.68 ? 300 ILE A N 1 ATOM 1909 C CA . ILE A 1 269 ? 48.984 -53.823 31.158 1.00 104.28 ? 300 ILE A CA 1 ATOM 1910 C C . ILE A 1 269 ? 49.231 -53.794 32.659 1.00 108.19 ? 300 ILE A C 1 ATOM 1911 O O . ILE A 1 269 ? 48.305 -53.592 33.430 1.00 113.99 ? 300 ILE A O 1 ATOM 1912 C CB . ILE A 1 269 ? 49.310 -55.228 30.641 1.00 102.44 ? 300 ILE A CB 1 ATOM 1913 C CG1 . ILE A 1 269 ? 48.855 -55.394 29.189 1.00 100.65 ? 300 ILE A CG1 1 ATOM 1914 C CG2 . ILE A 1 269 ? 48.675 -56.272 31.530 1.00 99.48 ? 300 ILE A CG2 1 ATOM 1915 C CD1 . ILE A 1 269 ? 49.329 -56.702 28.554 1.00 99.31 ? 300 ILE A CD1 1 ATOM 1916 N N . THR A 1 270 ? 50.480 -53.985 33.070 1.00 105.51 ? 301 THR A N 1 ATOM 1917 C CA . THR A 1 270 ? 50.827 -54.048 34.490 1.00 107.87 ? 301 THR A CA 1 ATOM 1918 C C . THR A 1 270 ? 50.346 -52.838 35.289 1.00 112.19 ? 301 THR A C 1 ATOM 1919 O O . THR A 1 270 ? 50.075 -52.949 36.480 1.00 117.61 ? 301 THR A O 1 ATOM 1920 C CB . THR A 1 270 ? 52.346 -54.240 34.702 1.00 112.58 ? 301 THR A CB 1 ATOM 1921 O OG1 . THR A 1 270 ? 52.727 -55.549 34.266 1.00 110.25 ? 301 THR A OG1 1 ATOM 1922 C CG2 . THR A 1 270 ? 52.707 -54.090 36.168 1.00 114.98 ? 301 THR A CG2 1 ATOM 1923 N N . THR A 1 271 ? 50.240 -51.684 34.641 1.00 109.72 ? 302 THR A N 1 ATOM 1924 C CA . THR A 1 271 ? 49.699 -50.508 35.309 1.00 113.01 ? 302 THR A CA 1 ATOM 1925 C C . THR A 1 271 ? 48.205 -50.669 35.516 1.00 120.18 ? 302 THR A C 1 ATOM 1926 O O . THR A 1 271 ? 47.716 -50.542 36.633 1.00 125.93 ? 302 THR A O 1 ATOM 1927 C CB . THR A 1 271 ? 49.898 -49.236 34.497 1.00 111.58 ? 302 THR A CB 1 ATOM 1928 O OG1 . THR A 1 271 ? 51.244 -49.176 34.031 1.00 114.38 ? 302 THR A OG1 1 ATOM 1929 C CG2 . THR A 1 271 ? 49.606 -48.011 35.349 1.00 115.13 ? 302 THR A CG2 1 ATOM 1930 N N . ALA A 1 272 ? 47.482 -50.931 34.429 1.00 117.51 ? 303 ALA A N 1 ATOM 1931 C CA . ALA A 1 272 ? 46.037 -51.116 34.486 1.00 118.40 ? 303 ALA A CA 1 ATOM 1932 C C . ALA A 1 272 ? 45.671 -52.111 35.581 1.00 123.30 ? 303 ALA A C 1 ATOM 1933 O O . ALA A 1 272 ? 44.801 -51.857 36.413 1.00 129.06 ? 303 ALA A O 1 ATOM 1934 C CB . ALA A 1 272 ? 45.531 -51.604 33.152 1.00 114.98 ? 303 ALA A CB 1 ATOM 1935 N N . ALA A 1 273 ? 46.349 -53.253 35.575 1.00 120.88 ? 304 ALA A N 1 ATOM 1936 C CA . ALA A 1 273 ? 46.114 -54.297 36.578 1.00 122.77 ? 304 ALA A CA 1 ATOM 1937 C C . ALA A 1 273 ? 46.336 -53.815 38.019 1.00 126.10 ? 304 ALA A C 1 ATOM 1938 O O . ALA A 1 273 ? 45.556 -54.130 38.927 1.00 132.69 ? 304 ALA A O 1 ATOM 1939 C CB . ALA A 1 273 ? 46.978 -55.535 36.289 1.00 120.50 ? 304 ALA A CB 1 ATOM 1940 N N . SER A 1 274 ? 47.406 -53.056 38.223 1.00 123.25 ? 305 SER A N 1 ATOM 1941 C CA . SER A 1 274 ? 47.710 -52.507 39.535 1.00 124.74 ? 305 SER A CA 1 ATOM 1942 C C . SER A 1 274 ? 46.686 -51.457 39.959 1.00 125.93 ? 305 SER A C 1 ATOM 1943 O O . SER A 1 274 ? 46.359 -51.353 41.135 1.00 129.65 ? 305 SER A O 1 ATOM 1944 C CB . SER A 1 274 ? 49.113 -51.901 39.553 1.00 124.72 ? 305 SER A CB 1 ATOM 1945 O OG . SER A 1 274 ? 50.100 -52.915 39.454 1.00 126.37 ? 305 SER A OG 1 ATOM 1946 N N . ASP A 1 275 ? 46.182 -50.674 39.011 1.00 125.07 ? 306 ASP A N 1 ATOM 1947 C CA . ASP A 1 275 ? 45.215 -49.639 39.345 1.00 127.14 ? 306 ASP A CA 1 ATOM 1948 C C . ASP A 1 275 ? 43.826 -50.228 39.568 1.00 133.20 ? 306 ASP A C 1 ATOM 1949 O O . ASP A 1 275 ? 42.967 -49.587 40.181 1.00 135.81 ? 306 ASP A O 1 ATOM 1950 C CB . ASP A 1 275 ? 45.187 -48.568 38.268 1.00 129.12 ? 306 ASP A CB 1 ATOM 1951 C CG . ASP A 1 275 ? 46.471 -47.782 38.218 1.00 135.29 ? 306 ASP A CG 1 ATOM 1952 O OD1 . ASP A 1 275 ? 47.528 -48.353 38.629 1.00 135.85 ? 306 ASP A OD1 1 ATOM 1953 O OD2 . ASP A 1 275 ? 46.428 -46.597 37.775 1.00 139.16 ? 306 ASP A OD2 1 ATOM 1954 N N . MET A 1 276 ? 43.607 -51.462 39.115 1.00 131.56 ? 307 MET A N 1 ATOM 1955 C CA . MET A 1 276 ? 42.336 -52.125 39.390 1.00 131.11 ? 307 MET A CA 1 ATOM 1956 C C . MET A 1 276 ? 42.397 -52.804 40.749 1.00 134.09 ? 307 MET A C 1 ATOM 1957 O O . MET A 1 276 ? 41.547 -52.566 41.602 1.00 137.98 ? 307 MET A O 1 ATOM 1958 C CB . MET A 1 276 ? 41.959 -53.132 38.303 1.00 130.58 ? 307 MET A CB 1 ATOM 1959 C CG . MET A 1 276 ? 40.453 -53.270 38.115 1.00 135.40 ? 307 MET A CG 1 ATOM 1960 S SD . MET A 1 276 ? 39.895 -54.508 36.910 1.00 144.39 ? 307 MET A SD 1 ATOM 1961 C CE . MET A 1 276 ? 39.987 -55.987 37.908 1.00 142.22 ? 307 MET A CE 1 ATOM 1962 N N . LEU A 1 277 ? 43.416 -53.634 40.957 1.00 133.31 ? 308 LEU A N 1 ATOM 1963 C CA . LEU A 1 277 ? 43.653 -54.210 42.273 1.00 131.77 ? 308 LEU A CA 1 ATOM 1964 C C . LEU A 1 277 ? 43.633 -53.099 43.322 1.00 134.34 ? 308 LEU A C 1 ATOM 1965 O O . LEU A 1 277 ? 43.303 -53.343 44.476 1.00 137.91 ? 308 LEU A O 1 ATOM 1966 C CB . LEU A 1 277 ? 44.978 -54.973 42.318 1.00 116.66 ? 308 LEU A CB 1 ATOM 1967 N N . SER A 1 278 ? 43.958 -51.875 42.914 1.00 134.61 ? 309 SER A N 1 ATOM 1968 C CA . SER A 1 278 ? 43.980 -50.737 43.835 1.00 136.97 ? 309 SER A CA 1 ATOM 1969 C C . SER A 1 278 ? 42.573 -50.242 44.185 1.00 139.81 ? 309 SER A C 1 ATOM 1970 O O . SER A 1 278 ? 42.318 -49.844 45.320 1.00 141.76 ? 309 SER A O 1 ATOM 1971 C CB . SER A 1 278 ? 44.810 -49.582 43.258 1.00 128.96 ? 309 SER A CB 1 ATOM 1972 N N . GLU A 1 279 ? 41.663 -50.259 43.215 1.00 138.00 ? 310 GLU A N 1 ATOM 1973 C CA . GLU A 1 279 ? 40.312 -49.737 43.435 1.00 139.28 ? 310 GLU A CA 1 ATOM 1974 C C . GLU A 1 279 ? 39.276 -50.832 43.765 1.00 143.05 ? 310 GLU A C 1 ATOM 1975 O O . GLU A 1 279 ? 38.229 -50.548 44.348 1.00 144.72 ? 310 GLU A O 1 ATOM 1976 C CB . GLU A 1 279 ? 39.857 -48.882 42.243 1.00 130.85 ? 310 GLU A CB 1 ATOM 1977 N N . HIS A 1 280 ? 39.575 -52.076 43.392 1.00 140.84 ? 311 HIS A N 1 ATOM 1978 C CA . HIS A 1 280 ? 38.721 -53.228 43.700 1.00 138.05 ? 311 HIS A CA 1 ATOM 1979 C C . HIS A 1 280 ? 39.612 -54.447 43.906 1.00 141.61 ? 311 HIS A C 1 ATOM 1980 O O . HIS A 1 280 ? 40.499 -54.693 43.098 1.00 146.79 ? 311 HIS A O 1 ATOM 1981 C CB . HIS A 1 280 ? 37.757 -53.516 42.548 1.00 139.24 ? 311 HIS A CB 1 ATOM 1982 C CG . HIS A 1 280 ? 37.252 -52.288 41.848 1.00 145.24 ? 311 HIS A CG 1 ATOM 1983 N ND1 . HIS A 1 280 ? 35.987 -51.794 42.029 1.00 153.99 ? 311 HIS A ND1 1 ATOM 1984 C CD2 . HIS A 1 280 ? 37.861 -51.466 40.955 1.00 142.92 ? 311 HIS A CD2 1 ATOM 1985 C CE1 . HIS A 1 280 ? 35.825 -50.707 41.283 1.00 147.94 ? 311 HIS A CE1 1 ATOM 1986 N NE2 . HIS A 1 280 ? 36.947 -50.491 40.627 1.00 142.25 ? 311 HIS A NE2 1 ATOM 1987 N N . SER A 1 281 ? 39.377 -55.220 44.962 1.00 137.06 ? 312 SER A N 1 ATOM 1988 C CA . SER A 1 281 ? 40.278 -56.326 45.309 1.00 142.70 ? 312 SER A CA 1 ATOM 1989 C C . SER A 1 281 ? 40.104 -57.435 44.263 1.00 146.35 ? 312 SER A C 1 ATOM 1990 O O . SER A 1 281 ? 39.705 -58.556 44.598 1.00 143.38 ? 312 SER A O 1 ATOM 1991 C CB . SER A 1 281 ? 39.897 -56.925 46.665 1.00 146.98 ? 312 SER A CB 1 ATOM 1992 N N . PHE A 1 282 ? 40.430 -57.131 43.008 1.00 146.63 ? 313 PHE A N 1 ATOM 1993 C CA . PHE A 1 282 ? 40.200 -58.065 41.908 1.00 148.00 ? 313 PHE A CA 1 ATOM 1994 C C . PHE A 1 282 ? 41.166 -57.816 40.737 1.00 145.80 ? 313 PHE A C 1 ATOM 1995 O O . PHE A 1 282 ? 41.493 -56.673 40.396 1.00 140.19 ? 313 PHE A O 1 ATOM 1996 C CB . PHE A 1 282 ? 38.766 -58.181 41.369 1.00 141.43 ? 313 PHE A CB 1 ATOM 1997 N N . ILE A 1 283 ? 41.624 -58.916 40.144 1.00 144.97 ? 314 ILE A N 1 ATOM 1998 C CA . ILE A 1 283 ? 42.225 -58.921 38.813 1.00 140.61 ? 314 ILE A CA 1 ATOM 1999 C C . ILE A 1 283 ? 41.649 -60.115 38.061 1.00 142.52 ? 314 ILE A C 1 ATOM 2000 O O . ILE A 1 283 ? 41.855 -61.264 38.464 1.00 142.52 ? 314 ILE A O 1 ATOM 2001 C CB . ILE A 1 283 ? 43.751 -59.047 38.856 1.00 137.09 ? 314 ILE A CB 1 ATOM 2002 C CG1 . ILE A 1 283 ? 44.169 -59.978 39.997 1.00 143.60 ? 314 ILE A CG1 1 ATOM 2003 C CG2 . ILE A 1 283 ? 44.381 -57.682 39.017 1.00 134.55 ? 314 ILE A CG2 1 ATOM 2004 C CD1 . ILE A 1 283 ? 45.628 -60.377 39.965 1.00 142.00 ? 314 ILE A CD1 1 ATOM 2005 N N . PRO A 1 284 ? 40.918 -59.845 36.968 1.00 141.43 ? 315 PRO A N 1 ATOM 2006 C CA . PRO A 1 284 ? 40.149 -60.856 36.228 1.00 140.53 ? 315 PRO A CA 1 ATOM 2007 C C . PRO A 1 284 ? 40.899 -62.176 36.025 1.00 136.91 ? 315 PRO A C 1 ATOM 2008 O O . PRO A 1 284 ? 42.004 -62.196 35.478 1.00 139.26 ? 315 PRO A O 1 ATOM 2009 C CB . PRO A 1 284 ? 39.875 -60.167 34.888 1.00 140.07 ? 315 PRO A CB 1 ATOM 2010 C CG . PRO A 1 284 ? 39.830 -58.707 35.235 1.00 132.43 ? 315 PRO A CG 1 ATOM 2011 C CD . PRO A 1 284 ? 40.852 -58.520 36.324 1.00 135.22 ? 315 PRO A CD 1 ATOM 2012 N N . GLU A 1 285 ? 40.300 -63.272 36.476 1.00 135.53 ? 316 GLU A N 1 ATOM 2013 C CA . GLU A 1 285 ? 40.926 -64.578 36.334 1.00 137.65 ? 316 GLU A CA 1 ATOM 2014 C C . GLU A 1 285 ? 41.321 -64.801 34.877 1.00 133.88 ? 316 GLU A C 1 ATOM 2015 O O . GLU A 1 285 ? 40.728 -64.212 33.972 1.00 132.99 ? 316 GLU A O 1 ATOM 2016 C CB . GLU A 1 285 ? 39.984 -65.687 36.815 1.00 133.05 ? 316 GLU A CB 1 ATOM 2017 N N . PRO A 1 286 ? 42.344 -65.632 34.650 1.00 129.68 ? 317 PRO A N 1 ATOM 2018 C CA . PRO A 1 286 ? 42.780 -66.005 33.301 1.00 129.74 ? 317 PRO A CA 1 ATOM 2019 C C . PRO A 1 286 ? 41.693 -66.749 32.533 1.00 132.05 ? 317 PRO A C 1 ATOM 2020 O O . PRO A 1 286 ? 41.219 -67.789 32.993 1.00 131.73 ? 317 PRO A O 1 ATOM 2021 C CB . PRO A 1 286 ? 43.950 -66.959 33.561 1.00 126.38 ? 317 PRO A CB 1 ATOM 2022 C CG . PRO A 1 286 ? 44.436 -66.603 34.911 1.00 130.59 ? 317 PRO A CG 1 ATOM 2023 C CD . PRO A 1 286 ? 43.226 -66.184 35.689 1.00 130.92 ? 317 PRO A CD 1 ATOM 2024 N N . LYS A 1 287 ? 41.305 -66.219 31.376 1.00 130.99 ? 318 LYS A N 1 ATOM 2025 C CA . LYS A 1 287 ? 40.413 -66.932 30.468 1.00 129.35 ? 318 LYS A CA 1 ATOM 2026 C C . LYS A 1 287 ? 41.226 -67.941 29.646 1.00 132.09 ? 318 LYS A C 1 ATOM 2027 O O . LYS A 1 287 ? 42.328 -67.634 29.188 1.00 133.37 ? 318 LYS A O 1 ATOM 2028 C CB . LYS A 1 287 ? 39.662 -65.947 29.571 1.00 120.57 ? 318 LYS A CB 1 ATOM 2029 C CG . LYS A 1 287 ? 38.450 -65.298 30.242 1.00 125.06 ? 318 LYS A CG 1 ATOM 2030 C CD . LYS A 1 287 ? 38.831 -64.465 31.467 1.00 129.68 ? 318 LYS A CD 1 ATOM 2031 C CE . LYS A 1 287 ? 39.265 -63.049 31.092 1.00 127.40 ? 318 LYS A CE 1 ATOM 2032 N NZ . LYS A 1 287 ? 38.124 -62.247 30.565 1.00 120.98 ? 318 LYS A NZ 1 ATOM 2033 N N . SER A 1 288 ? 40.689 -69.145 29.468 1.00 131.44 ? 319 SER A N 1 ATOM 2034 C CA . SER A 1 288 ? 41.496 -70.258 28.964 1.00 135.84 ? 319 SER A CA 1 ATOM 2035 C C . SER A 1 288 ? 40.985 -70.924 27.680 1.00 138.73 ? 319 SER A C 1 ATOM 2036 O O . SER A 1 288 ? 41.362 -72.066 27.380 1.00 139.10 ? 319 SER A O 1 ATOM 2037 C CB . SER A 1 288 ? 41.664 -71.323 30.057 1.00 136.67 ? 319 SER A CB 1 ATOM 2038 O OG . SER A 1 288 ? 42.109 -70.748 31.275 1.00 142.09 ? 319 SER A OG 1 ATOM 2039 N N . SER A 1 289 ? 40.136 -70.232 26.924 1.00 130.08 ? 320 SER A N 1 ATOM 2040 C CA . SER A 1 289 ? 39.674 -70.778 25.653 1.00 124.28 ? 320 SER A CA 1 ATOM 2041 C C . SER A 1 289 ? 39.279 -69.680 24.687 1.00 117.31 ? 320 SER A C 1 ATOM 2042 O O . SER A 1 289 ? 38.472 -68.816 25.023 1.00 113.85 ? 320 SER A O 1 ATOM 2043 C CB . SER A 1 289 ? 38.504 -71.749 25.863 1.00 128.19 ? 320 SER A CB 1 ATOM 2044 O OG . SER A 1 289 ? 38.283 -72.552 24.708 1.00 124.74 ? 320 SER A OG 1 ATOM 2045 N N . CYS A 1 290 ? 39.863 -69.722 23.491 1.00 118.47 ? 321 CYS A N 1 ATOM 2046 C CA . CYS A 1 290 ? 39.504 -68.809 22.410 1.00 118.58 ? 321 CYS A CA 1 ATOM 2047 C C . CYS A 1 290 ? 38.130 -69.174 21.872 1.00 120.12 ? 321 CYS A C 1 ATOM 2048 O O . CYS A 1 290 ? 37.376 -68.307 21.428 1.00 118.09 ? 321 CYS A O 1 ATOM 2049 C CB . CYS A 1 290 ? 40.500 -68.896 21.246 1.00 117.17 ? 321 CYS A CB 1 ATOM 2050 S SG . CYS A 1 290 ? 42.262 -68.663 21.620 1.00 137.62 ? 321 CYS A SG 1 ATOM 2051 N N . TYR A 1 291 ? 37.817 -70.466 21.903 1.00 120.84 ? 322 TYR A N 1 ATOM 2052 C CA . TYR A 1 291 ? 36.602 -70.973 21.282 1.00 119.77 ? 322 TYR A CA 1 ATOM 2053 C C . TYR A 1 291 ? 35.503 -71.291 22.289 1.00 124.90 ? 322 TYR A C 1 ATOM 2054 O O . TYR A 1 291 ? 34.523 -70.557 22.410 1.00 127.08 ? 322 TYR A O 1 ATOM 2055 C CB . TYR A 1 291 ? 36.924 -72.217 20.465 1.00 115.84 ? 322 TYR A CB 1 ATOM 2056 C CG . TYR A 1 291 ? 38.196 -72.095 19.673 1.00 114.91 ? 322 TYR A CG 1 ATOM 2057 C CD1 . TYR A 1 291 ? 39.345 -72.761 20.074 1.00 119.01 ? 322 TYR A CD1 1 ATOM 2058 C CD2 . TYR A 1 291 ? 38.254 -71.307 18.530 1.00 111.84 ? 322 TYR A CD2 1 ATOM 2059 C CE1 . TYR A 1 291 ? 40.522 -72.656 19.354 1.00 121.22 ? 322 TYR A CE1 1 ATOM 2060 C CE2 . TYR A 1 291 ? 39.427 -71.191 17.799 1.00 117.37 ? 322 TYR A CE2 1 ATOM 2061 C CZ . TYR A 1 291 ? 40.564 -71.870 18.217 1.00 122.44 ? 322 TYR A CZ 1 ATOM 2062 O OH . TYR A 1 291 ? 41.748 -71.775 17.506 1.00 116.76 ? 322 TYR A OH 1 ATOM 2063 N N . ASN A 1 292 ? 35.670 -72.397 23.002 1.00 129.77 ? 323 ASN A N 1 ATOM 2064 C CA . ASN A 1 292 ? 34.653 -72.879 23.930 1.00 131.25 ? 323 ASN A CA 1 ATOM 2065 C C . ASN A 1 292 ? 34.417 -71.883 25.084 1.00 132.56 ? 323 ASN A C 1 ATOM 2066 O O . ASN A 1 292 ? 34.996 -72.009 26.164 1.00 133.55 ? 323 ASN A O 1 ATOM 2067 C CB . ASN A 1 292 ? 35.028 -74.288 24.425 1.00 132.51 ? 323 ASN A CB 1 ATOM 2068 C CG . ASN A 1 292 ? 35.591 -75.193 23.297 1.00 132.36 ? 323 ASN A CG 1 ATOM 2069 O OD1 . ASN A 1 292 ? 35.185 -75.100 22.131 1.00 126.25 ? 323 ASN A OD1 1 ATOM 2070 N ND2 . ASN A 1 292 ? 36.526 -76.070 23.656 1.00 130.25 ? 323 ASN A ND2 1 ATOM 2071 N N . THR A 1 293 ? 33.544 -70.908 24.832 1.00 133.96 ? 324 THR A N 1 ATOM 2072 C CA . THR A 1 293 ? 33.393 -69.706 25.660 1.00 141.86 ? 324 THR A CA 1 ATOM 2073 C C . THR A 1 293 ? 32.261 -69.732 26.695 1.00 152.90 ? 324 THR A C 1 ATOM 2074 O O . THR A 1 293 ? 31.160 -69.218 26.447 1.00 142.72 ? 324 THR A O 1 ATOM 2075 C CB . THR A 1 293 ? 33.172 -68.467 24.764 1.00 139.13 ? 324 THR A CB 1 ATOM 2076 O OG1 . THR A 1 293 ? 34.337 -68.253 23.960 1.00 133.65 ? 324 THR A OG1 1 ATOM 2077 C CG2 . THR A 1 293 ? 32.891 -67.217 25.600 1.00 140.92 ? 324 THR A CG2 1 ATOM 2078 N N . HIS A 1 294 ? 32.542 -70.315 27.858 1.00 161.02 ? 325 HIS A N 1 ATOM 2079 C CA . HIS A 1 294 ? 31.649 -70.203 29.010 1.00 164.91 ? 325 HIS A CA 1 ATOM 2080 C C . HIS A 1 294 ? 32.034 -68.964 29.829 1.00 163.48 ? 325 HIS A C 1 ATOM 2081 O O . HIS A 1 294 ? 31.489 -68.708 30.910 1.00 155.26 ? 325 HIS A O 1 ATOM 2082 C CB . HIS A 1 294 ? 31.712 -71.465 29.862 1.00 160.24 ? 325 HIS A CB 1 ATOM 2083 N N . GLU A 1 295 ? 32.980 -68.200 29.282 1.00 165.66 ? 326 GLU A N 1 ATOM 2084 C CA . GLU A 1 295 ? 33.492 -66.984 29.908 1.00 163.39 ? 326 GLU A CA 1 ATOM 2085 C C . GLU A 1 295 ? 32.662 -65.753 29.539 1.00 156.87 ? 326 GLU A C 1 ATOM 2086 O O . GLU A 1 295 ? 33.201 -64.742 29.076 1.00 146.45 ? 326 GLU A O 1 ATOM 2087 C CB . GLU A 1 295 ? 34.961 -66.761 29.527 1.00 154.86 ? 326 GLU A CB 1 ATOM 2088 N N . LYS A 1 296 ? 31.350 -65.849 29.747 1.00 160.58 ? 327 LYS A N 1 ATOM 2089 C CA . LYS A 1 296 ? 30.456 -64.698 29.605 1.00 160.95 ? 327 LYS A CA 1 ATOM 2090 C C . LYS A 1 296 ? 30.675 -63.697 30.748 1.00 156.54 ? 327 LYS A C 1 ATOM 2091 O O . LYS A 1 296 ? 29.712 -63.130 31.280 1.00 144.27 ? 327 LYS A O 1 ATOM 2092 C CB . LYS A 1 296 ? 28.985 -65.144 29.569 1.00 150.42 ? 327 LYS A CB 1 ATOM 2093 N N . ARG A 1 297 ? 31.944 -63.493 31.120 1.00 155.13 ? 328 ARG A N 1 ATOM 2094 C CA . ARG A 1 297 ? 32.315 -62.583 32.208 1.00 143.31 ? 328 ARG A CA 1 ATOM 2095 C C . ARG A 1 297 ? 32.443 -61.154 31.680 1.00 138.71 ? 328 ARG A C 1 ATOM 2096 O O . ARG A 1 297 ? 33.344 -60.406 32.072 1.00 127.73 ? 328 ARG A O 1 ATOM 2097 C CB . ARG A 1 297 ? 33.611 -63.042 32.885 1.00 129.22 ? 328 ARG A CB 1 ATOM 2098 N N . ILE A 1 298 ? 31.497 -60.793 30.813 1.00 140.98 ? 329 ILE A N 1 ATOM 2099 C CA . ILE A 1 298 ? 31.537 -59.568 30.015 1.00 129.88 ? 329 ILE A CA 1 ATOM 2100 C C . ILE A 1 298 ? 31.609 -58.268 30.819 1.00 129.69 ? 329 ILE A C 1 ATOM 2101 O O . ILE A 1 298 ? 31.696 -57.187 30.242 1.00 131.99 ? 329 ILE A O 1 ATOM 2102 C CB . ILE A 1 298 ? 30.333 -59.503 29.042 1.00 109.38 ? 329 ILE A CB 1 ATOM 2103 N N . TYR A 1 299 ? 31.590 -58.365 32.143 1.00 132.63 ? 330 TYR A N 1 ATOM 2104 C CA . TYR A 1 299 ? 31.586 -57.160 32.971 1.00 136.91 ? 330 TYR A CA 1 ATOM 2105 C C . TYR A 1 299 ? 32.958 -56.797 33.526 1.00 135.09 ? 330 TYR A C 1 ATOM 2106 O O . TYR A 1 299 ? 33.401 -55.655 33.397 1.00 132.57 ? 330 TYR A O 1 ATOM 2107 C CB . TYR A 1 299 ? 30.562 -57.262 34.105 1.00 138.37 ? 330 TYR A CB 1 ATOM 2108 C CG . TYR A 1 299 ? 30.531 -56.032 34.982 1.00 140.10 ? 330 TYR A CG 1 ATOM 2109 C CD1 . TYR A 1 299 ? 30.364 -54.766 34.429 1.00 140.89 ? 330 TYR A CD1 1 ATOM 2110 C CD2 . TYR A 1 299 ? 30.672 -56.134 36.360 1.00 141.95 ? 330 TYR A CD2 1 ATOM 2111 C CE1 . TYR A 1 299 ? 30.340 -53.638 35.223 1.00 142.23 ? 330 TYR A CE1 1 ATOM 2112 C CE2 . TYR A 1 299 ? 30.646 -55.014 37.165 1.00 144.30 ? 330 TYR A CE2 1 ATOM 2113 C CZ . TYR A 1 299 ? 30.480 -53.769 36.592 1.00 146.09 ? 330 TYR A CZ 1 ATOM 2114 O OH . TYR A 1 299 ? 30.452 -52.654 37.396 1.00 144.82 ? 330 TYR A OH 1 ATOM 2115 N N . GLN A 1 300 ? 33.622 -57.763 34.152 1.00 132.71 ? 331 GLN A N 1 ATOM 2116 C CA . GLN A 1 300 ? 34.972 -57.538 34.651 1.00 135.34 ? 331 GLN A CA 1 ATOM 2117 C C . GLN A 1 300 ? 35.900 -57.070 33.535 1.00 133.04 ? 331 GLN A C 1 ATOM 2118 O O . GLN A 1 300 ? 36.897 -56.400 33.787 1.00 132.07 ? 331 GLN A O 1 ATOM 2119 C CB . GLN A 1 300 ? 35.525 -58.797 35.308 1.00 137.37 ? 331 GLN A CB 1 ATOM 2120 C CG . GLN A 1 300 ? 34.894 -59.113 36.647 1.00 142.50 ? 331 GLN A CG 1 ATOM 2121 C CD . GLN A 1 300 ? 35.468 -60.370 37.265 1.00 149.88 ? 331 GLN A CD 1 ATOM 2122 O OE1 . GLN A 1 300 ? 36.404 -60.968 36.730 1.00 145.07 ? 331 GLN A OE1 1 ATOM 2123 N NE2 . GLN A 1 300 ? 34.905 -60.783 38.395 1.00 155.91 ? 331 GLN A NE2 1 ATOM 2124 N N . SER A 1 301 ? 35.569 -57.432 32.300 1.00 134.20 ? 332 SER A N 1 ATOM 2125 C CA . SER A 1 301 ? 36.258 -56.884 31.144 1.00 128.98 ? 332 SER A CA 1 ATOM 2126 C C . SER A 1 301 ? 36.147 -55.374 31.162 1.00 126.56 ? 332 SER A C 1 ATOM 2127 O O . SER A 1 301 ? 37.098 -54.690 31.519 1.00 130.70 ? 332 SER A O 1 ATOM 2128 C CB . SER A 1 301 ? 35.660 -57.416 29.846 1.00 131.06 ? 332 SER A CB 1 ATOM 2129 O OG . SER A 1 301 ? 35.953 -58.790 29.697 1.00 131.33 ? 332 SER A OG 1 ATOM 2130 N N . ASN A 1 302 ? 34.983 -54.854 30.786 1.00 125.53 ? 333 ASN A N 1 ATOM 2131 C CA . ASN A 1 302 ? 34.781 -53.407 30.715 1.00 131.35 ? 333 ASN A CA 1 ATOM 2132 C C . ASN A 1 302 ? 35.517 -52.627 31.804 1.00 128.19 ? 333 ASN A C 1 ATOM 2133 O O . ASN A 1 302 ? 36.019 -51.531 31.553 1.00 121.71 ? 333 ASN A O 1 ATOM 2134 C CB . ASN A 1 302 ? 33.292 -53.062 30.758 1.00 140.34 ? 333 ASN A CB 1 ATOM 2135 C CG . ASN A 1 302 ? 32.484 -53.850 29.754 1.00 143.31 ? 333 ASN A CG 1 ATOM 2136 O OD1 . ASN A 1 302 ? 31.260 -53.945 29.867 1.00 142.45 ? 333 ASN A OD1 1 ATOM 2137 N ND2 . ASN A 1 302 ? 33.164 -54.427 28.765 1.00 142.25 ? 333 ASN A ND2 1 ATOM 2138 N N . MET A 1 303 ? 35.570 -53.193 33.011 1.00 130.24 ? 334 MET A N 1 ATOM 2139 C CA . MET A 1 303 ? 36.276 -52.568 34.129 1.00 126.01 ? 334 MET A CA 1 ATOM 2140 C C . MET A 1 303 ? 37.766 -52.435 33.814 1.00 124.18 ? 334 MET A C 1 ATOM 2141 O O . MET A 1 303 ? 38.316 -51.333 33.826 1.00 122.39 ? 334 MET A O 1 ATOM 2142 C CB . MET A 1 303 ? 36.061 -53.354 35.429 1.00 121.54 ? 334 MET A CB 1 ATOM 2143 N N . LEU A 1 304 ? 38.418 -53.558 33.532 1.00 122.21 ? 335 LEU A N 1 ATOM 2144 C CA . LEU A 1 304 ? 39.809 -53.531 33.110 1.00 116.73 ? 335 LEU A CA 1 ATOM 2145 C C . LEU A 1 304 ? 39.963 -52.491 32.011 1.00 116.43 ? 335 LEU A C 1 ATOM 2146 O O . LEU A 1 304 ? 40.740 -51.549 32.129 1.00 117.03 ? 335 LEU A O 1 ATOM 2147 C CB . LEU A 1 304 ? 40.228 -54.899 32.579 1.00 115.04 ? 335 LEU A CB 1 ATOM 2148 C CG . LEU A 1 304 ? 41.619 -55.410 32.964 1.00 116.33 ? 335 LEU A CG 1 ATOM 2149 C CD1 . LEU A 1 304 ? 42.215 -56.187 31.809 1.00 108.29 ? 335 LEU A CD1 1 ATOM 2150 C CD2 . LEU A 1 304 ? 42.556 -54.281 33.390 1.00 114.64 ? 335 LEU A CD2 1 ATOM 2151 N N . ASN A 1 305 ? 39.191 -52.662 30.948 1.00 115.82 ? 336 ASN A N 1 ATOM 2152 C CA . ASN A 1 305 ? 39.274 -51.794 29.787 1.00 115.00 ? 336 ASN A CA 1 ATOM 2153 C C . ASN A 1 305 ? 39.279 -50.309 30.119 1.00 114.38 ? 336 ASN A C 1 ATOM 2154 O O . ASN A 1 305 ? 39.713 -49.502 29.308 1.00 116.99 ? 336 ASN A O 1 ATOM 2155 C CB . ASN A 1 305 ? 38.139 -52.100 28.815 1.00 117.29 ? 336 ASN A CB 1 ATOM 2156 C CG . ASN A 1 305 ? 38.479 -51.725 27.392 1.00 117.50 ? 336 ASN A CG 1 ATOM 2157 O OD1 . ASN A 1 305 ? 38.284 -50.579 26.973 1.00 113.98 ? 336 ASN A OD1 1 ATOM 2158 N ND2 . ASN A 1 305 ? 38.988 -52.694 26.631 1.00 112.30 ? 336 ASN A ND2 1 ATOM 2159 N N . ARG A 1 306 ? 38.797 -49.941 31.299 1.00 117.84 ? 337 ARG A N 1 ATOM 2160 C CA . ARG A 1 306 ? 38.783 -48.533 31.683 1.00 119.26 ? 337 ARG A CA 1 ATOM 2161 C C . ARG A 1 306 ? 40.173 -48.097 32.121 1.00 113.49 ? 337 ARG A C 1 ATOM 2162 O O . ARG A 1 306 ? 40.516 -46.920 32.063 1.00 115.09 ? 337 ARG A O 1 ATOM 2163 C CB . ARG A 1 306 ? 37.753 -48.264 32.788 1.00 115.49 ? 337 ARG A CB 1 ATOM 2164 N N . TYR A 1 307 ? 40.980 -49.057 32.546 1.00 114.35 ? 338 TYR A N 1 ATOM 2165 C CA . TYR A 1 307 ? 42.312 -48.747 33.046 1.00 120.95 ? 338 TYR A CA 1 ATOM 2166 C C . TYR A 1 307 ? 43.392 -48.848 31.967 1.00 118.05 ? 338 TYR A C 1 ATOM 2167 O O . TYR A 1 307 ? 44.285 -48.010 31.913 1.00 119.27 ? 338 TYR A O 1 ATOM 2168 C CB . TYR A 1 307 ? 42.646 -49.618 34.261 1.00 124.40 ? 338 TYR A CB 1 ATOM 2169 C CG . TYR A 1 307 ? 41.717 -49.382 35.437 1.00 128.25 ? 338 TYR A CG 1 ATOM 2170 C CD1 . TYR A 1 307 ? 41.343 -48.093 35.797 1.00 126.44 ? 338 TYR A CD1 1 ATOM 2171 C CD2 . TYR A 1 307 ? 41.219 -50.444 36.188 1.00 128.85 ? 338 TYR A CD2 1 ATOM 2172 C CE1 . TYR A 1 307 ? 40.496 -47.864 36.867 1.00 131.47 ? 338 TYR A CE1 1 ATOM 2173 C CE2 . TYR A 1 307 ? 40.374 -50.225 37.265 1.00 129.34 ? 338 TYR A CE2 1 ATOM 2174 C CZ . TYR A 1 307 ? 40.016 -48.930 37.601 1.00 136.54 ? 338 TYR A CZ 1 ATOM 2175 O OH . TYR A 1 307 ? 39.175 -48.690 38.668 1.00 140.17 ? 338 TYR A OH 1 ATOM 2176 N N . LEU A 1 308 ? 43.300 -49.866 31.113 1.00 115.22 ? 339 LEU A N 1 ATOM 2177 C CA . LEU A 1 308 ? 44.192 -50.004 29.963 1.00 109.50 ? 339 LEU A CA 1 ATOM 2178 C C . LEU A 1 308 ? 44.183 -48.761 29.096 1.00 112.59 ? 339 LEU A C 1 ATOM 2179 O O . LEU A 1 308 ? 45.215 -48.337 28.578 1.00 118.51 ? 339 LEU A O 1 ATOM 2180 C CB . LEU A 1 308 ? 43.738 -51.155 29.079 1.00 103.78 ? 339 LEU A CB 1 ATOM 2181 C CG . LEU A 1 308 ? 43.867 -52.591 29.552 1.00 106.78 ? 339 LEU A CG 1 ATOM 2182 C CD1 . LEU A 1 308 ? 43.450 -53.472 28.406 1.00 109.17 ? 339 LEU A CD1 1 ATOM 2183 C CD2 . LEU A 1 308 ? 45.288 -52.911 29.971 1.00 110.04 ? 339 LEU A CD2 1 ATOM 2184 N N . ILE A 1 309 ? 42.996 -48.195 28.933 1.00 109.02 ? 340 ILE A N 1 ATOM 2185 C CA . ILE A 1 309 ? 42.750 -47.146 27.961 1.00 109.57 ? 340 ILE A CA 1 ATOM 2186 C C . ILE A 1 309 ? 43.463 -45.835 28.304 1.00 116.54 ? 340 ILE A C 1 ATOM 2187 O O . ILE A 1 309 ? 43.381 -44.860 27.555 1.00 116.76 ? 340 ILE A O 1 ATOM 2188 C CB . ILE A 1 309 ? 41.214 -46.907 27.807 1.00 112.75 ? 340 ILE A CB 1 ATOM 2189 C CG1 . ILE A 1 309 ? 40.871 -46.445 26.396 1.00 118.06 ? 340 ILE A CG1 1 ATOM 2190 C CG2 . ILE A 1 309 ? 40.676 -45.941 28.856 1.00 112.08 ? 340 ILE A CG2 1 ATOM 2191 C CD1 . ILE A 1 309 ? 41.234 -47.471 25.354 1.00 122.02 ? 340 ILE A CD1 1 ATOM 2192 N N . ASN A 1 310 ? 44.183 -45.815 29.419 1.00 116.07 ? 341 ASN A N 1 ATOM 2193 C CA . ASN A 1 310 ? 44.572 -44.545 30.004 1.00 118.40 ? 341 ASN A CA 1 ATOM 2194 C C . ASN A 1 310 ? 45.938 -44.517 30.671 1.00 121.86 ? 341 ASN A C 1 ATOM 2195 O O . ASN A 1 310 ? 46.230 -43.618 31.454 1.00 125.20 ? 341 ASN A O 1 ATOM 2196 C CB . ASN A 1 310 ? 43.517 -44.149 31.024 1.00 124.87 ? 341 ASN A CB 1 ATOM 2197 C CG . ASN A 1 310 ? 43.316 -42.663 31.104 1.00 144.69 ? 341 ASN A CG 1 ATOM 2198 O OD1 . ASN A 1 310 ? 43.476 -41.937 30.115 1.00 143.10 ? 341 ASN A OD1 1 ATOM 2199 N ND2 . ASN A 1 310 ? 42.956 -42.192 32.291 1.00 155.69 ? 341 ASN A ND2 1 ATOM 2200 N N . VAL A 1 311 ? 46.786 -45.484 30.350 1.00 118.31 ? 342 VAL A N 1 ATOM 2201 C CA . VAL A 1 311 ? 48.065 -45.605 31.033 1.00 119.74 ? 342 VAL A CA 1 ATOM 2202 C C . VAL A 1 311 ? 49.032 -44.480 30.682 1.00 124.12 ? 342 VAL A C 1 ATOM 2203 O O . VAL A 1 311 ? 49.146 -44.080 29.525 1.00 123.80 ? 342 VAL A O 1 ATOM 2204 C CB . VAL A 1 311 ? 48.746 -46.945 30.710 1.00 119.94 ? 342 VAL A CB 1 ATOM 2205 C CG1 . VAL A 1 311 ? 49.679 -47.339 31.836 1.00 115.29 ? 342 VAL A CG1 1 ATOM 2206 C CG2 . VAL A 1 311 ? 47.706 -48.032 30.476 1.00 121.18 ? 342 VAL A CG2 1 ATOM 2207 N N . THR A 1 312 ? 49.718 -43.965 31.695 1.00 130.19 ? 343 THR A N 1 ATOM 2208 C CA . THR A 1 312 ? 50.870 -43.099 31.474 1.00 132.31 ? 343 THR A CA 1 ATOM 2209 C C . THR A 1 312 ? 52.028 -43.604 32.342 1.00 129.79 ? 343 THR A C 1 ATOM 2210 O O . THR A 1 312 ? 51.899 -43.734 33.559 1.00 132.75 ? 343 THR A O 1 ATOM 2211 C CB . THR A 1 312 ? 50.544 -41.610 31.721 1.00 133.78 ? 343 THR A CB 1 ATOM 2212 O OG1 . THR A 1 312 ? 51.526 -40.799 31.068 1.00 136.33 ? 343 THR A OG1 1 ATOM 2213 C CG2 . THR A 1 312 ? 50.507 -41.283 33.214 1.00 133.47 ? 343 THR A CG2 1 ATOM 2214 N N . PHE A 1 313 ? 53.105 -44.012 31.692 1.00 126.44 ? 344 PHE A N 1 ATOM 2215 C CA . PHE A 1 313 ? 54.175 -44.674 32.400 1.00 128.96 ? 344 PHE A CA 1 ATOM 2216 C C . PHE A 1 313 ? 55.524 -44.034 32.236 1.00 136.43 ? 344 PHE A C 1 ATOM 2217 O O . PHE A 1 313 ? 56.071 -43.953 31.152 1.00 137.42 ? 344 PHE A O 1 ATOM 2218 C CB . PHE A 1 313 ? 54.221 -46.108 31.910 1.00 121.34 ? 344 PHE A CB 1 ATOM 2219 C CG . PHE A 1 313 ? 55.459 -46.838 32.266 1.00 122.23 ? 344 PHE A CG 1 ATOM 2220 C CD1 . PHE A 1 313 ? 55.608 -47.401 33.504 1.00 126.21 ? 344 PHE A CD1 1 ATOM 2221 C CD2 . PHE A 1 313 ? 56.455 -47.003 31.343 1.00 120.30 ? 344 PHE A CD2 1 ATOM 2222 C CE1 . PHE A 1 313 ? 56.737 -48.093 33.819 1.00 124.89 ? 344 PHE A CE1 1 ATOM 2223 C CE2 . PHE A 1 313 ? 57.584 -47.690 31.656 1.00 119.80 ? 344 PHE A CE2 1 ATOM 2224 C CZ . PHE A 1 313 ? 57.726 -48.234 32.895 1.00 121.09 ? 344 PHE A CZ 1 ATOM 2225 N N . GLU A 1 314 ? 56.055 -43.571 33.348 1.00 139.22 ? 345 GLU A N 1 ATOM 2226 C CA . GLU A 1 314 ? 57.344 -42.940 33.364 1.00 136.22 ? 345 GLU A CA 1 ATOM 2227 C C . GLU A 1 314 ? 57.248 -41.801 32.369 1.00 137.13 ? 345 GLU A C 1 ATOM 2228 O O . GLU A 1 314 ? 56.274 -41.065 32.388 1.00 129.06 ? 345 GLU A O 1 ATOM 2229 C CB . GLU A 1 314 ? 58.472 -43.938 33.097 1.00 126.23 ? 345 GLU A CB 1 ATOM 2230 C CG . GLU A 1 314 ? 58.668 -44.916 34.273 1.00 128.73 ? 345 GLU A CG 1 ATOM 2231 C CD . GLU A 1 314 ? 59.966 -45.701 34.213 1.00 134.82 ? 345 GLU A CD 1 ATOM 2232 O OE1 . GLU A 1 314 ? 60.469 -46.153 35.268 1.00 134.37 ? 345 GLU A OE1 1 ATOM 2233 O OE2 . GLU A 1 314 ? 60.471 -45.896 33.099 1.00 132.96 ? 345 GLU A OE2 1 ATOM 2234 N N . GLY A 1 315 ? 58.225 -41.650 31.489 1.00 132.66 ? 346 GLY A N 1 ATOM 2235 C CA . GLY A 1 315 ? 58.157 -40.555 30.538 1.00 139.75 ? 346 GLY A CA 1 ATOM 2236 C C . GLY A 1 315 ? 57.040 -40.519 29.513 1.00 144.74 ? 346 GLY A C 1 ATOM 2237 O O . GLY A 1 315 ? 56.448 -39.482 29.248 1.00 131.55 ? 346 GLY A O 1 ATOM 2238 N N . ARG A 1 316 ? 56.757 -41.678 28.940 1.00 147.72 ? 347 ARG A N 1 ATOM 2239 C CA . ARG A 1 316 ? 55.741 -41.847 27.904 1.00 141.09 ? 347 ARG A CA 1 ATOM 2240 C C . ARG A 1 316 ? 54.279 -41.758 28.321 1.00 139.50 ? 347 ARG A C 1 ATOM 2241 O O . ARG A 1 316 ? 53.930 -42.103 29.442 1.00 134.35 ? 347 ARG A O 1 ATOM 2242 C CB . ARG A 1 316 ? 55.994 -43.138 27.125 1.00 121.07 ? 347 ARG A CB 1 ATOM 2243 N N . ASP A 1 317 ? 53.422 -41.313 27.411 1.00 135.61 ? 348 ASP A N 1 ATOM 2244 C CA . ASP A 1 317 ? 51.995 -41.366 27.662 1.00 132.01 ? 348 ASP A CA 1 ATOM 2245 C C . ASP A 1 317 ? 51.432 -42.355 26.655 1.00 130.96 ? 348 ASP A C 1 ATOM 2246 O O . ASP A 1 317 ? 51.625 -42.209 25.462 1.00 129.94 ? 348 ASP A O 1 ATOM 2247 C CB . ASP A 1 317 ? 51.347 -40.018 27.447 1.00 136.17 ? 348 ASP A CB 1 ATOM 2248 C CG . ASP A 1 317 ? 49.876 -40.138 27.221 1.00 135.41 ? 348 ASP A CG 1 ATOM 2249 O OD1 . ASP A 1 317 ? 49.430 -41.273 26.981 1.00 134.62 ? 348 ASP A OD1 1 ATOM 2250 O OD2 . ASP A 1 317 ? 49.168 -39.119 27.280 1.00 130.57 ? 348 ASP A OD2 1 ATOM 2251 N N . LEU A 1 318 ? 50.707 -43.349 27.136 1.00 122.35 ? 349 LEU A N 1 ATOM 2252 C CA . LEU A 1 318 ? 50.238 -44.415 26.272 1.00 117.72 ? 349 LEU A CA 1 ATOM 2253 C C . LEU A 1 318 ? 48.751 -44.549 26.203 1.00 119.23 ? 349 LEU A C 1 ATOM 2254 O O . LEU A 1 318 ? 48.232 -45.616 25.959 1.00 114.23 ? 349 LEU A O 1 ATOM 2255 C CB . LEU A 1 318 ? 50.838 -45.722 26.735 1.00 116.75 ? 349 LEU A CB 1 ATOM 2256 C CG . LEU A 1 318 ? 52.197 -45.395 27.317 1.00 108.82 ? 349 LEU A CG 1 ATOM 2257 C CD1 . LEU A 1 318 ? 53.116 -46.567 27.227 1.00 104.93 ? 349 LEU A CD1 1 ATOM 2258 C CD2 . LEU A 1 318 ? 52.727 -44.255 26.516 1.00 110.77 ? 349 LEU A CD2 1 ATOM 2259 N N . SER A 1 319 ? 48.047 -43.479 26.464 1.00 116.83 ? 350 SER A N 1 ATOM 2260 C CA . SER A 1 319 ? 46.602 -43.609 26.489 1.00 117.89 ? 350 SER A CA 1 ATOM 2261 C C . SER A 1 319 ? 46.108 -43.927 25.090 1.00 112.68 ? 350 SER A C 1 ATOM 2262 O O . SER A 1 319 ? 46.660 -43.440 24.104 1.00 110.65 ? 350 SER A O 1 ATOM 2263 C CB . SER A 1 319 ? 45.934 -42.354 27.046 1.00 117.71 ? 350 SER A CB 1 ATOM 2264 O OG . SER A 1 319 ? 46.237 -41.231 26.249 1.00 125.35 ? 350 SER A OG 1 ATOM 2265 N N . PHE A 1 320 ? 45.079 -44.768 25.020 1.00 112.11 ? 351 PHE A N 1 ATOM 2266 C CA . PHE A 1 320 ? 44.531 -45.234 23.753 1.00 108.33 ? 351 PHE A CA 1 ATOM 2267 C C . PHE A 1 320 ? 43.215 -44.558 23.402 1.00 110.55 ? 351 PHE A C 1 ATOM 2268 O O . PHE A 1 320 ? 42.507 -44.043 24.267 1.00 109.64 ? 351 PHE A O 1 ATOM 2269 C CB . PHE A 1 320 ? 44.309 -46.741 23.788 1.00 104.43 ? 351 PHE A CB 1 ATOM 2270 C CG . PHE A 1 320 ? 45.561 -47.544 23.663 1.00 104.17 ? 351 PHE A CG 1 ATOM 2271 C CD1 . PHE A 1 320 ? 45.981 -48.356 24.697 1.00 102.51 ? 351 PHE A CD1 1 ATOM 2272 C CD2 . PHE A 1 320 ? 46.312 -47.500 22.507 1.00 105.10 ? 351 PHE A CD2 1 ATOM 2273 C CE1 . PHE A 1 320 ? 47.118 -49.101 24.580 1.00 100.77 ? 351 PHE A CE1 1 ATOM 2274 C CE2 . PHE A 1 320 ? 47.458 -48.243 22.388 1.00 101.73 ? 351 PHE A CE2 1 ATOM 2275 C CZ . PHE A 1 320 ? 47.861 -49.042 23.426 1.00 102.25 ? 351 PHE A CZ 1 ATOM 2276 N N . SER A 1 321 ? 42.893 -44.577 22.115 1.00 108.84 ? 352 SER A N 1 ATOM 2277 C CA . SER A 1 321 ? 41.659 -44.000 21.629 1.00 107.91 ? 352 SER A CA 1 ATOM 2278 C C . SER A 1 321 ? 40.554 -45.039 21.725 1.00 111.48 ? 352 SER A C 1 ATOM 2279 O O . SER A 1 321 ? 40.818 -46.203 22.020 1.00 106.91 ? 352 SER A O 1 ATOM 2280 C CB . SER A 1 321 ? 41.823 -43.516 20.185 1.00 110.85 ? 352 SER A CB 1 ATOM 2281 O OG . SER A 1 321 ? 41.567 -44.547 19.249 1.00 109.99 ? 352 SER A OG 1 ATOM 2282 N N . GLU A 1 322 ? 39.317 -44.605 21.483 1.00 120.92 ? 353 GLU A N 1 ATOM 2283 C CA . GLU A 1 322 ? 38.150 -45.482 21.552 1.00 116.99 ? 353 GLU A CA 1 ATOM 2284 C C . GLU A 1 322 ? 38.270 -46.641 20.567 1.00 117.29 ? 353 GLU A C 1 ATOM 2285 O O . GLU A 1 322 ? 37.993 -47.783 20.917 1.00 120.36 ? 353 GLU A O 1 ATOM 2286 C CB . GLU A 1 322 ? 36.860 -44.695 21.289 1.00 114.16 ? 353 GLU A CB 1 ATOM 2287 N N . ASP A 1 323 ? 38.697 -46.346 19.342 1.00 117.08 ? 354 ASP A N 1 ATOM 2288 C CA . ASP A 1 323 ? 38.801 -47.361 18.293 1.00 115.49 ? 354 ASP A CA 1 ATOM 2289 C C . ASP A 1 323 ? 40.090 -48.167 18.390 1.00 110.81 ? 354 ASP A C 1 ATOM 2290 O O . ASP A 1 323 ? 40.468 -48.863 17.449 1.00 109.53 ? 354 ASP A O 1 ATOM 2291 C CB . ASP A 1 323 ? 38.719 -46.711 16.916 1.00 119.69 ? 354 ASP A CB 1 ATOM 2292 C CG . ASP A 1 323 ? 37.940 -45.412 16.935 1.00 128.11 ? 354 ASP A CG 1 ATOM 2293 O OD1 . ASP A 1 323 ? 36.707 -45.453 17.153 1.00 127.32 ? 354 ASP A OD1 1 ATOM 2294 O OD2 . ASP A 1 323 ? 38.570 -44.348 16.728 1.00 135.92 ? 354 ASP A OD2 1 ATOM 2295 N N . GLY A 1 324 ? 40.771 -48.055 19.522 1.00 107.68 ? 355 GLY A N 1 ATOM 2296 C CA . GLY A 1 324 ? 41.920 -48.897 19.795 1.00 108.90 ? 355 GLY A CA 1 ATOM 2297 C C . GLY A 1 324 ? 43.212 -48.532 19.086 1.00 107.64 ? 355 GLY A C 1 ATOM 2298 O O . GLY A 1 324 ? 43.991 -49.413 18.710 1.00 105.76 ? 355 GLY A O 1 ATOM 2299 N N . TYR A 1 325 ? 43.442 -47.237 18.898 1.00 104.28 ? 356 TYR A N 1 ATOM 2300 C CA . TYR A 1 325 ? 44.728 -46.766 18.421 1.00 98.76 ? 356 TYR A CA 1 ATOM 2301 C C . TYR A 1 325 ? 45.399 -45.966 19.511 1.00 102.11 ? 356 TYR A C 1 ATOM 2302 O O . TYR A 1 325 ? 44.760 -45.527 20.459 1.00 104.27 ? 356 TYR A O 1 ATOM 2303 C CB . TYR A 1 325 ? 44.576 -45.872 17.207 1.00 99.15 ? 356 TYR A CB 1 ATOM 2304 C CG . TYR A 1 325 ? 43.813 -46.480 16.066 1.00 105.99 ? 356 TYR A CG 1 ATOM 2305 C CD1 . TYR A 1 325 ? 44.384 -47.451 15.250 1.00 106.44 ? 356 TYR A CD1 1 ATOM 2306 C CD2 . TYR A 1 325 ? 42.524 -46.057 15.781 1.00 111.03 ? 356 TYR A CD2 1 ATOM 2307 C CE1 . TYR A 1 325 ? 43.676 -47.988 14.188 1.00 105.17 ? 356 TYR A CE1 1 ATOM 2308 C CE2 . TYR A 1 325 ? 41.812 -46.584 14.731 1.00 108.74 ? 356 TYR A CE2 1 ATOM 2309 C CZ . TYR A 1 325 ? 42.386 -47.542 13.939 1.00 108.72 ? 356 TYR A CZ 1 ATOM 2310 O OH . TYR A 1 325 ? 41.639 -48.039 12.899 1.00 112.17 ? 356 TYR A OH 1 ATOM 2311 N N . GLN A 1 326 ? 46.700 -45.773 19.365 1.00 107.11 ? 357 GLN A N 1 ATOM 2312 C CA . GLN A 1 326 ? 47.444 -44.942 20.285 1.00 105.64 ? 357 GLN A CA 1 ATOM 2313 C C . GLN A 1 326 ? 47.009 -43.511 20.055 1.00 107.27 ? 357 GLN A C 1 ATOM 2314 O O . GLN A 1 326 ? 46.843 -43.082 18.915 1.00 106.06 ? 357 GLN A O 1 ATOM 2315 C CB . GLN A 1 326 ? 48.918 -45.082 19.989 1.00 105.41 ? 357 GLN A CB 1 ATOM 2316 C CG . GLN A 1 326 ? 49.809 -45.008 21.183 1.00 108.64 ? 357 GLN A CG 1 ATOM 2317 C CD . GLN A 1 326 ? 51.246 -45.225 20.782 1.00 115.91 ? 357 GLN A CD 1 ATOM 2318 O OE1 . GLN A 1 326 ? 51.573 -45.213 19.593 1.00 113.95 ? 357 GLN A OE1 1 ATOM 2319 N NE2 . GLN A 1 326 ? 52.116 -45.432 21.764 1.00 123.56 ? 357 GLN A NE2 1 ATOM 2320 N N . MET A 1 327 ? 46.804 -42.771 21.133 1.00 111.67 ? 358 MET A N 1 ATOM 2321 C CA . MET A 1 327 ? 46.353 -41.393 21.002 1.00 115.25 ? 358 MET A CA 1 ATOM 2322 C C . MET A 1 327 ? 47.490 -40.442 20.678 1.00 117.83 ? 358 MET A C 1 ATOM 2323 O O . MET A 1 327 ? 47.342 -39.556 19.843 1.00 118.23 ? 358 MET A O 1 ATOM 2324 C CB . MET A 1 327 ? 45.641 -40.933 22.264 1.00 115.42 ? 358 MET A CB 1 ATOM 2325 C CG . MET A 1 327 ? 44.263 -41.511 22.397 1.00 116.66 ? 358 MET A CG 1 ATOM 2326 S SD . MET A 1 327 ? 43.138 -40.294 23.072 1.00 132.96 ? 358 MET A SD 1 ATOM 2327 C CE . MET A 1 327 ? 44.057 -39.774 24.524 1.00 129.21 ? 358 MET A CE 1 ATOM 2328 N N . HIS A 1 328 ? 48.625 -40.627 21.340 1.00 119.68 ? 359 HIS A N 1 ATOM 2329 C CA . HIS A 1 328 ? 49.780 -39.779 21.095 1.00 120.63 ? 359 HIS A CA 1 ATOM 2330 C C . HIS A 1 328 ? 50.994 -40.587 20.651 1.00 118.60 ? 359 HIS A C 1 ATOM 2331 O O . HIS A 1 328 ? 51.813 -41.002 21.475 1.00 119.05 ? 359 HIS A O 1 ATOM 2332 C CB . HIS A 1 328 ? 50.097 -38.962 22.341 1.00 129.31 ? 359 HIS A CB 1 ATOM 2333 C CG . HIS A 1 328 ? 48.886 -38.360 22.981 1.00 132.03 ? 359 HIS A CG 1 ATOM 2334 N ND1 . HIS A 1 328 ? 48.231 -37.270 22.460 1.00 139.37 ? 359 HIS A ND1 1 ATOM 2335 C CD2 . HIS A 1 328 ? 48.203 -38.714 24.096 1.00 132.84 ? 359 HIS A CD2 1 ATOM 2336 C CE1 . HIS A 1 328 ? 47.199 -36.966 23.227 1.00 141.43 ? 359 HIS A CE1 1 ATOM 2337 N NE2 . HIS A 1 328 ? 47.160 -37.829 24.227 1.00 140.20 ? 359 HIS A NE2 1 ATOM 2338 N N . PRO A 1 329 ? 51.099 -40.828 19.339 1.00 113.10 ? 360 PRO A N 1 ATOM 2339 C CA . PRO A 1 329 ? 52.233 -41.537 18.755 1.00 114.84 ? 360 PRO A CA 1 ATOM 2340 C C . PRO A 1 329 ? 53.256 -40.523 18.275 1.00 121.92 ? 360 PRO A C 1 ATOM 2341 O O . PRO A 1 329 ? 52.864 -39.418 17.877 1.00 122.72 ? 360 PRO A O 1 ATOM 2342 C CB . PRO A 1 329 ? 51.615 -42.245 17.540 1.00 112.24 ? 360 PRO A CB 1 ATOM 2343 C CG . PRO A 1 329 ? 50.181 -41.769 17.452 1.00 110.74 ? 360 PRO A CG 1 ATOM 2344 C CD . PRO A 1 329 ? 50.062 -40.571 18.332 1.00 110.65 ? 360 PRO A CD 1 ATOM 2345 N N . LYS A 1 330 ? 54.540 -40.873 18.330 1.00 123.66 ? 361 LYS A N 1 ATOM 2346 C CA . LYS A 1 330 ? 55.569 -40.044 17.709 1.00 121.06 ? 361 LYS A CA 1 ATOM 2347 C C . LYS A 1 330 ? 55.718 -40.533 16.277 1.00 117.35 ? 361 LYS A C 1 ATOM 2348 O O . LYS A 1 330 ? 55.984 -41.710 16.033 1.00 118.70 ? 361 LYS A O 1 ATOM 2349 C CB . LYS A 1 330 ? 56.899 -40.125 18.471 1.00 114.58 ? 361 LYS A CB 1 ATOM 2350 N N . LEU A 1 331 ? 55.512 -39.633 15.329 1.00 111.74 ? 362 LEU A N 1 ATOM 2351 C CA . LEU A 1 331 ? 55.522 -40.017 13.932 1.00 109.38 ? 362 LEU A CA 1 ATOM 2352 C C . LEU A 1 331 ? 56.776 -39.552 13.210 1.00 110.70 ? 362 LEU A C 1 ATOM 2353 O O . LEU A 1 331 ? 57.519 -38.703 13.701 1.00 114.46 ? 362 LEU A O 1 ATOM 2354 C CB . LEU A 1 331 ? 54.299 -39.444 13.233 1.00 108.55 ? 362 LEU A CB 1 ATOM 2355 C CG . LEU A 1 331 ? 52.968 -39.998 13.696 1.00 101.99 ? 362 LEU A CG 1 ATOM 2356 C CD1 . LEU A 1 331 ? 51.922 -39.610 12.686 1.00 92.94 ? 362 LEU A CD1 1 ATOM 2357 C CD2 . LEU A 1 331 ? 53.100 -41.501 13.806 1.00 109.59 ? 362 LEU A CD2 1 ATOM 2358 N N . VAL A 1 332 ? 56.988 -40.109 12.026 1.00 102.86 ? 363 VAL A N 1 ATOM 2359 C CA . VAL A 1 332 ? 58.107 -39.742 11.190 1.00 97.51 ? 363 VAL A CA 1 ATOM 2360 C C . VAL A 1 332 ? 57.628 -39.667 9.753 1.00 99.18 ? 363 VAL A C 1 ATOM 2361 O O . VAL A 1 332 ? 57.093 -40.637 9.239 1.00 103.48 ? 363 VAL A O 1 ATOM 2362 C CB . VAL A 1 332 ? 59.178 -40.815 11.260 1.00 92.88 ? 363 VAL A CB 1 ATOM 2363 C CG1 . VAL A 1 332 ? 60.139 -40.644 10.128 1.00 90.42 ? 363 VAL A CG1 1 ATOM 2364 C CG2 . VAL A 1 332 ? 59.885 -40.768 12.594 1.00 97.50 ? 363 VAL A CG2 1 ATOM 2365 N N . ILE A 1 333 ? 57.794 -38.528 9.096 1.00 98.03 ? 364 ILE A N 1 ATOM 2366 C CA . ILE A 1 333 ? 57.513 -38.480 7.669 1.00 98.53 ? 364 ILE A CA 1 ATOM 2367 C C . ILE A 1 333 ? 58.752 -38.965 6.923 1.00 99.68 ? 364 ILE A C 1 ATOM 2368 O O . ILE A 1 333 ? 59.867 -38.553 7.232 1.00 99.43 ? 364 ILE A O 1 ATOM 2369 C CB . ILE A 1 333 ? 57.104 -37.081 7.193 1.00 96.91 ? 364 ILE A CB 1 ATOM 2370 C CG1 . ILE A 1 333 ? 55.815 -36.649 7.878 1.00 96.76 ? 364 ILE A CG1 1 ATOM 2371 C CG2 . ILE A 1 333 ? 56.888 -37.082 5.697 1.00 98.15 ? 364 ILE A CG2 1 ATOM 2372 C CD1 . ILE A 1 333 ? 56.006 -36.269 9.309 1.00 105.87 ? 364 ILE A CD1 1 ATOM 2373 N N . ILE A 1 334 ? 58.562 -39.859 5.959 1.00 97.95 ? 365 ILE A N 1 ATOM 2374 C CA . ILE A 1 334 ? 59.693 -40.454 5.264 1.00 97.21 ? 365 ILE A CA 1 ATOM 2375 C C . ILE A 1 334 ? 59.532 -40.381 3.758 1.00 97.99 ? 365 ILE A C 1 ATOM 2376 O O . ILE A 1 334 ? 58.436 -40.171 3.248 1.00 97.69 ? 365 ILE A O 1 ATOM 2377 C CB . ILE A 1 334 ? 59.880 -41.903 5.668 1.00 92.29 ? 365 ILE A CB 1 ATOM 2378 C CG1 . ILE A 1 334 ? 58.691 -42.721 5.190 1.00 97.15 ? 365 ILE A CG1 1 ATOM 2379 C CG2 . ILE A 1 334 ? 59.996 -42.010 7.164 1.00 85.58 ? 365 ILE A CG2 1 ATOM 2380 C CD1 . ILE A 1 334 ? 58.634 -44.074 5.814 1.00 100.79 ? 365 ILE A CD1 1 ATOM 2381 N N . LEU A 1 335 ? 60.636 -40.571 3.049 1.00 98.52 ? 366 LEU A N 1 ATOM 2382 C CA . LEU A 1 335 ? 60.669 -40.312 1.623 1.00 100.15 ? 366 LEU A CA 1 ATOM 2383 C C . LEU A 1 335 ? 61.406 -41.414 0.901 1.00 104.19 ? 366 LEU A C 1 ATOM 2384 O O . LEU A 1 335 ? 62.509 -41.792 1.296 1.00 106.70 ? 366 LEU A O 1 ATOM 2385 C CB . LEU A 1 335 ? 61.377 -38.985 1.371 1.00 102.51 ? 366 LEU A CB 1 ATOM 2386 C CG . LEU A 1 335 ? 61.331 -38.387 -0.026 1.00 102.69 ? 366 LEU A CG 1 ATOM 2387 C CD1 . LEU A 1 335 ? 59.974 -38.628 -0.672 1.00 107.28 ? 366 LEU A CD1 1 ATOM 2388 C CD2 . LEU A 1 335 ? 61.620 -36.917 0.090 1.00 96.83 ? 366 LEU A CD2 1 ATOM 2389 N N . LEU A 1 336 ? 60.798 -41.937 -0.157 1.00 104.39 ? 367 LEU A N 1 ATOM 2390 C CA . LEU A 1 336 ? 61.465 -42.946 -0.958 1.00 107.90 ? 367 LEU A CA 1 ATOM 2391 C C . LEU A 1 336 ? 62.447 -42.219 -1.852 1.00 111.73 ? 367 LEU A C 1 ATOM 2392 O O . LEU A 1 336 ? 62.047 -41.506 -2.775 1.00 109.37 ? 367 LEU A O 1 ATOM 2393 C CB . LEU A 1 336 ? 60.471 -43.759 -1.792 1.00 107.34 ? 367 LEU A CB 1 ATOM 2394 C CG . LEU A 1 336 ? 61.102 -45.020 -2.385 1.00 102.46 ? 367 LEU A CG 1 ATOM 2395 C CD1 . LEU A 1 336 ? 61.781 -45.814 -1.292 1.00 99.01 ? 367 LEU A CD1 1 ATOM 2396 C CD2 . LEU A 1 336 ? 60.083 -45.856 -3.111 1.00 102.59 ? 367 LEU A CD2 1 ATOM 2397 N N . ASN A 1 337 ? 63.733 -42.397 -1.565 1.00 113.07 ? 368 ASN A N 1 ATOM 2398 C CA . ASN A 1 337 ? 64.778 -41.654 -2.255 1.00 115.51 ? 368 ASN A CA 1 ATOM 2399 C C . ASN A 1 337 ? 65.194 -42.251 -3.602 1.00 120.00 ? 368 ASN A C 1 ATOM 2400 O O . ASN A 1 337 ? 64.470 -43.053 -4.200 1.00 114.12 ? 368 ASN A O 1 ATOM 2401 C CB . ASN A 1 337 ? 65.996 -41.446 -1.337 1.00 116.32 ? 368 ASN A CB 1 ATOM 2402 C CG . ASN A 1 337 ? 66.756 -42.731 -1.060 1.00 114.12 ? 368 ASN A CG 1 ATOM 2403 O OD1 . ASN A 1 337 ? 66.915 -43.570 -1.940 1.00 114.63 ? 368 ASN A OD1 1 ATOM 2404 N ND2 . ASN A 1 337 ? 67.247 -42.880 0.164 1.00 112.36 ? 368 ASN A ND2 1 ATOM 2405 N N . LYS A 1 338 ? 66.369 -41.842 -4.072 1.00 128.06 ? 369 LYS A N 1 ATOM 2406 C CA . LYS A 1 338 ? 66.867 -42.246 -5.384 1.00 126.04 ? 369 LYS A CA 1 ATOM 2407 C C . LYS A 1 338 ? 67.564 -43.616 -5.339 1.00 117.15 ? 369 LYS A C 1 ATOM 2408 O O . LYS A 1 338 ? 67.327 -44.467 -6.201 1.00 112.23 ? 369 LYS A O 1 ATOM 2409 C CB . LYS A 1 338 ? 67.785 -41.157 -5.956 1.00 120.18 ? 369 LYS A CB 1 ATOM 2410 N N . GLU A 1 339 ? 68.410 -43.822 -4.329 1.00 114.82 ? 370 GLU A N 1 ATOM 2411 C CA . GLU A 1 339 ? 69.050 -45.118 -4.107 1.00 117.53 ? 370 GLU A CA 1 ATOM 2412 C C . GLU A 1 339 ? 68.033 -46.133 -3.563 1.00 120.13 ? 370 GLU A C 1 ATOM 2413 O O . GLU A 1 339 ? 68.385 -47.267 -3.232 1.00 115.82 ? 370 GLU A O 1 ATOM 2414 C CB . GLU A 1 339 ? 70.244 -44.980 -3.155 1.00 107.01 ? 370 GLU A CB 1 ATOM 2415 N N . ARG A 1 340 ? 66.774 -45.700 -3.472 1.00 120.07 ? 371 ARG A N 1 ATOM 2416 C CA . ARG A 1 340 ? 65.643 -46.531 -3.038 1.00 115.59 ? 371 ARG A CA 1 ATOM 2417 C C . ARG A 1 340 ? 65.685 -46.992 -1.578 1.00 113.96 ? 371 ARG A C 1 ATOM 2418 O O . ARG A 1 340 ? 65.338 -48.132 -1.263 1.00 112.44 ? 371 ARG A O 1 ATOM 2419 C CB . ARG A 1 340 ? 65.432 -47.704 -3.989 1.00 111.75 ? 371 ARG A CB 1 ATOM 2420 C CG . ARG A 1 340 ? 65.261 -47.246 -5.414 1.00 114.10 ? 371 ARG A CG 1 ATOM 2421 C CD . ARG A 1 340 ? 64.768 -48.362 -6.296 1.00 125.10 ? 371 ARG A CD 1 ATOM 2422 N NE . ARG A 1 340 ? 63.400 -48.751 -5.967 1.00 129.48 ? 371 ARG A NE 1 ATOM 2423 C CZ . ARG A 1 340 ? 62.324 -48.061 -6.326 1.00 126.00 ? 371 ARG A CZ 1 ATOM 2424 N NH1 . ARG A 1 340 ? 62.454 -46.934 -7.019 1.00 122.68 ? 371 ARG A NH1 1 ATOM 2425 N NH2 . ARG A 1 340 ? 61.120 -48.498 -5.985 1.00 121.33 ? 371 ARG A NH2 1 ATOM 2426 N N . LYS A 1 341 ? 66.111 -46.089 -0.701 1.00 113.94 ? 372 LYS A N 1 ATOM 2427 C CA . LYS A 1 341 ? 65.967 -46.258 0.737 1.00 112.64 ? 372 LYS A CA 1 ATOM 2428 C C . LYS A 1 341 ? 64.887 -45.272 1.200 1.00 113.66 ? 372 LYS A C 1 ATOM 2429 O O . LYS A 1 341 ? 64.401 -44.470 0.399 1.00 112.95 ? 372 LYS A O 1 ATOM 2430 C CB . LYS A 1 341 ? 67.298 -45.981 1.437 1.00 104.02 ? 372 LYS A CB 1 ATOM 2431 N N . TRP A 1 342 ? 64.484 -45.337 2.468 1.00 109.81 ? 373 TRP A N 1 ATOM 2432 C CA . TRP A 1 342 ? 63.549 -44.343 2.998 1.00 106.59 ? 373 TRP A CA 1 ATOM 2433 C C . TRP A 1 342 ? 64.329 -43.381 3.870 1.00 103.49 ? 373 TRP A C 1 ATOM 2434 O O . TRP A 1 342 ? 65.014 -43.808 4.790 1.00 103.13 ? 373 TRP A O 1 ATOM 2435 C CB . TRP A 1 342 ? 62.425 -44.982 3.834 1.00 108.72 ? 373 TRP A CB 1 ATOM 2436 C CG . TRP A 1 342 ? 61.345 -45.732 3.051 1.00 105.94 ? 373 TRP A CG 1 ATOM 2437 C CD1 . TRP A 1 342 ? 61.297 -47.075 2.808 1.00 107.35 ? 373 TRP A CD1 1 ATOM 2438 C CD2 . TRP A 1 342 ? 60.160 -45.179 2.445 1.00 104.41 ? 373 TRP A CD2 1 ATOM 2439 N NE1 . TRP A 1 342 ? 60.174 -47.388 2.078 1.00 108.99 ? 373 TRP A NE1 1 ATOM 2440 C CE2 . TRP A 1 342 ? 59.461 -46.242 1.842 1.00 102.83 ? 373 TRP A CE2 1 ATOM 2441 C CE3 . TRP A 1 342 ? 59.627 -43.888 2.350 1.00 107.05 ? 373 TRP A CE3 1 ATOM 2442 C CZ2 . TRP A 1 342 ? 58.261 -46.053 1.154 1.00 96.13 ? 373 TRP A CZ2 1 ATOM 2443 C CZ3 . TRP A 1 342 ? 58.430 -43.708 1.667 1.00 100.69 ? 373 TRP A CZ3 1 ATOM 2444 C CH2 . TRP A 1 342 ? 57.769 -44.782 1.077 1.00 95.34 ? 373 TRP A CH2 1 ATOM 2445 N N . GLU A 1 343 ? 64.220 -42.087 3.586 1.00 103.99 ? 374 GLU A N 1 ATOM 2446 C CA . GLU A 1 343 ? 64.855 -41.061 4.406 1.00 101.39 ? 374 GLU A CA 1 ATOM 2447 C C . GLU A 1 343 ? 63.874 -40.435 5.401 1.00 102.40 ? 374 GLU A C 1 ATOM 2448 O O . GLU A 1 343 ? 62.720 -40.185 5.055 1.00 102.23 ? 374 GLU A O 1 ATOM 2449 C CB . GLU A 1 343 ? 65.378 -39.943 3.515 1.00 109.47 ? 374 GLU A CB 1 ATOM 2450 C CG . GLU A 1 343 ? 66.483 -40.320 2.559 1.00 121.33 ? 374 GLU A CG 1 ATOM 2451 C CD . GLU A 1 343 ? 67.222 -39.094 2.007 1.00 133.86 ? 374 GLU A CD 1 ATOM 2452 O OE1 . GLU A 1 343 ? 66.677 -37.955 2.069 1.00 126.60 ? 374 GLU A OE1 1 ATOM 2453 O OE2 . GLU A 1 343 ? 68.360 -39.283 1.512 1.00 133.15 ? 374 GLU A OE2 1 ATOM 2454 N N . ARG A 1 344 ? 64.325 -40.165 6.625 1.00 95.18 ? 375 ARG A N 1 ATOM 2455 C CA . ARG A 1 344 ? 63.522 -39.370 7.557 1.00 94.34 ? 375 ARG A CA 1 ATOM 2456 C C . ARG A 1 344 ? 63.544 -37.893 7.106 1.00 97.41 ? 375 ARG A C 1 ATOM 2457 O O . ARG A 1 344 ? 64.598 -37.355 6.796 1.00 98.44 ? 375 ARG A O 1 ATOM 2458 C CB . ARG A 1 344 ? 64.036 -39.541 8.997 1.00 81.69 ? 375 ARG A CB 1 ATOM 2459 N N . VAL A 1 345 ? 62.393 -37.238 7.029 1.00 95.27 ? 376 VAL A N 1 ATOM 2460 C CA . VAL A 1 345 ? 62.369 -35.869 6.514 1.00 96.61 ? 376 VAL A CA 1 ATOM 2461 C C . VAL A 1 345 ? 61.381 -34.965 7.247 1.00 105.15 ? 376 VAL A C 1 ATOM 2462 O O . VAL A 1 345 ? 60.994 -33.909 6.744 1.00 103.67 ? 376 VAL A O 1 ATOM 2463 C CB . VAL A 1 345 ? 62.026 -35.852 5.013 1.00 20.00 ? 376 VAL A CB 1 ATOM 2464 C CG1 . VAL A 1 345 ? 63.110 -36.554 4.211 1.00 20.00 ? 376 VAL A CG1 1 ATOM 2465 C CG2 . VAL A 1 345 ? 60.670 -36.496 4.769 1.00 20.00 ? 376 VAL A CG2 1 ATOM 2466 N N . GLY A 1 346 ? 60.989 -35.385 8.443 1.00 108.61 ? 377 GLY A N 1 ATOM 2467 C CA . GLY A 1 346 ? 60.020 -34.659 9.243 1.00 106.92 ? 377 GLY A CA 1 ATOM 2468 C C . GLY A 1 346 ? 59.631 -35.466 10.466 1.00 104.70 ? 377 GLY A C 1 ATOM 2469 O O . GLY A 1 346 ? 59.719 -36.688 10.475 1.00 103.72 ? 377 GLY A O 1 ATOM 2470 N N . LYS A 1 347 ? 59.221 -34.779 11.517 1.00 105.78 ? 378 LYS A N 1 ATOM 2471 C CA . LYS A 1 347 ? 58.731 -35.444 12.705 1.00 106.04 ? 378 LYS A CA 1 ATOM 2472 C C . LYS A 1 347 ? 57.369 -34.829 13.045 1.00 115.83 ? 378 LYS A C 1 ATOM 2473 O O . LYS A 1 347 ? 57.057 -33.719 12.607 1.00 116.43 ? 378 LYS A O 1 ATOM 2474 C CB . LYS A 1 347 ? 59.729 -35.290 13.856 1.00 91.18 ? 378 LYS A CB 1 ATOM 2475 N N . TRP A 1 348 ? 56.538 -35.561 13.781 1.00 116.73 ? 379 TRP A N 1 ATOM 2476 C CA . TRP A 1 348 ? 55.304 -34.993 14.317 1.00 119.12 ? 379 TRP A CA 1 ATOM 2477 C C . TRP A 1 348 ? 55.139 -35.392 15.775 1.00 123.33 ? 379 TRP A C 1 ATOM 2478 O O . TRP A 1 348 ? 55.147 -36.575 16.109 1.00 119.29 ? 379 TRP A O 1 ATOM 2479 C CB . TRP A 1 348 ? 54.106 -35.430 13.496 1.00 114.20 ? 379 TRP A CB 1 ATOM 2480 C CG . TRP A 1 348 ? 52.788 -35.361 14.210 1.00 123.88 ? 379 TRP A CG 1 ATOM 2481 C CD1 . TRP A 1 348 ? 52.389 -36.099 15.298 1.00 129.50 ? 379 TRP A CD1 1 ATOM 2482 C CD2 . TRP A 1 348 ? 51.669 -34.555 13.849 1.00 126.64 ? 379 TRP A CD2 1 ATOM 2483 N NE1 . TRP A 1 348 ? 51.096 -35.781 15.643 1.00 125.48 ? 379 TRP A NE1 1 ATOM 2484 C CE2 . TRP A 1 348 ? 50.630 -34.835 14.767 1.00 130.04 ? 379 TRP A CE2 1 ATOM 2485 C CE3 . TRP A 1 348 ? 51.442 -33.613 12.840 1.00 128.78 ? 379 TRP A CE3 1 ATOM 2486 C CZ2 . TRP A 1 348 ? 49.388 -34.202 14.709 1.00 138.43 ? 379 TRP A CZ2 1 ATOM 2487 C CZ3 . TRP A 1 348 ? 50.201 -32.982 12.782 1.00 134.60 ? 379 TRP A CZ3 1 ATOM 2488 C CH2 . TRP A 1 348 ? 49.192 -33.279 13.711 1.00 137.80 ? 379 TRP A CH2 1 ATOM 2489 N N . LYS A 1 349 ? 55.002 -34.391 16.638 1.00 131.71 ? 380 LYS A N 1 ATOM 2490 C CA . LYS A 1 349 ? 55.028 -34.607 18.080 1.00 135.24 ? 380 LYS A CA 1 ATOM 2491 C C . LYS A 1 349 ? 53.612 -34.642 18.610 1.00 137.64 ? 380 LYS A C 1 ATOM 2492 O O . LYS A 1 349 ? 53.098 -35.710 18.942 1.00 144.17 ? 380 LYS A O 1 ATOM 2493 C CB . LYS A 1 349 ? 55.833 -33.504 18.778 1.00 140.09 ? 380 LYS A CB 1 ATOM 2494 N N . ASP A 1 350 ? 52.987 -33.472 18.696 1.00 132.77 ? 381 ASP A N 1 ATOM 2495 C CA . ASP A 1 350 ? 51.565 -33.398 19.008 1.00 138.16 ? 381 ASP A CA 1 ATOM 2496 C C . ASP A 1 350 ? 50.917 -32.168 18.404 1.00 136.53 ? 381 ASP A C 1 ATOM 2497 O O . ASP A 1 350 ? 50.977 -31.086 18.975 1.00 143.73 ? 381 ASP A O 1 ATOM 2498 C CB . ASP A 1 350 ? 51.308 -33.487 20.514 1.00 143.64 ? 381 ASP A CB 1 ATOM 2499 C CG . ASP A 1 350 ? 50.609 -34.795 20.911 1.00 155.26 ? 381 ASP A CG 1 ATOM 2500 O OD1 . ASP A 1 350 ? 50.190 -35.561 20.011 1.00 149.77 ? 381 ASP A OD1 1 ATOM 2501 O OD2 . ASP A 1 350 ? 50.453 -35.050 22.123 1.00 156.28 ? 381 ASP A OD2 1 ATOM 2502 N N . LYS A 1 351 ? 50.295 -32.361 17.243 1.00 134.64 ? 382 LYS A N 1 ATOM 2503 C CA . LYS A 1 351 ? 49.783 -31.270 16.420 1.00 133.60 ? 382 LYS A CA 1 ATOM 2504 C C . LYS A 1 351 ? 50.929 -30.373 15.928 1.00 136.17 ? 382 LYS A C 1 ATOM 2505 O O . LYS A 1 351 ? 50.706 -29.394 15.211 1.00 135.56 ? 382 LYS A O 1 ATOM 2506 C CB . LYS A 1 351 ? 48.739 -30.473 17.180 1.00 129.99 ? 382 LYS A CB 1 ATOM 2507 N N . SER A 1 352 ? 52.154 -30.736 16.307 1.00 132.88 ? 383 SER A N 1 ATOM 2508 C CA . SER A 1 352 ? 53.343 -29.956 15.983 1.00 129.76 ? 383 SER A CA 1 ATOM 2509 C C . SER A 1 352 ? 54.202 -30.657 14.937 1.00 128.35 ? 383 SER A C 1 ATOM 2510 O O . SER A 1 352 ? 55.004 -31.535 15.268 1.00 126.20 ? 383 SER A O 1 ATOM 2511 C CB . SER A 1 352 ? 54.173 -29.703 17.245 1.00 129.96 ? 383 SER A CB 1 ATOM 2512 N N . LEU A 1 353 ? 54.042 -30.251 13.679 1.00 125.50 ? 384 LEU A N 1 ATOM 2513 C CA . LEU A 1 353 ? 54.762 -30.867 12.561 1.00 123.44 ? 384 LEU A CA 1 ATOM 2514 C C . LEU A 1 353 ? 56.094 -30.188 12.239 1.00 118.29 ? 384 LEU A C 1 ATOM 2515 O O . LEU A 1 353 ? 56.117 -29.132 11.612 1.00 122.73 ? 384 LEU A O 1 ATOM 2516 C CB . LEU A 1 353 ? 53.884 -30.873 11.303 1.00 122.68 ? 384 LEU A CB 1 ATOM 2517 C CG . LEU A 1 353 ? 54.553 -31.366 10.016 1.00 116.49 ? 384 LEU A CG 1 ATOM 2518 C CD1 . LEU A 1 353 ? 54.871 -32.842 10.137 1.00 115.82 ? 384 LEU A CD1 1 ATOM 2519 C CD2 . LEU A 1 353 ? 53.685 -31.099 8.789 1.00 110.04 ? 384 LEU A CD2 1 ATOM 2520 N N . GLN A 1 354 ? 57.202 -30.796 12.647 1.00 113.60 ? 385 GLN A N 1 ATOM 2521 C CA . GLN A 1 354 ? 58.513 -30.244 12.320 1.00 118.96 ? 385 GLN A CA 1 ATOM 2522 C C . GLN A 1 354 ? 59.191 -30.913 11.115 1.00 117.48 ? 385 GLN A C 1 ATOM 2523 O O . GLN A 1 354 ? 59.574 -32.077 11.174 1.00 119.08 ? 385 GLN A O 1 ATOM 2524 C CB . GLN A 1 354 ? 59.438 -30.294 13.535 1.00 124.33 ? 385 GLN A CB 1 ATOM 2525 C CG . GLN A 1 354 ? 60.911 -30.180 13.172 1.00 136.01 ? 385 GLN A CG 1 ATOM 2526 C CD . GLN A 1 354 ? 61.776 -29.705 14.328 1.00 147.08 ? 385 GLN A CD 1 ATOM 2527 O OE1 . GLN A 1 354 ? 61.327 -29.652 15.478 1.00 154.38 ? 385 GLN A OE1 1 ATOM 2528 N NE2 . GLN A 1 354 ? 63.028 -29.354 14.025 1.00 140.03 ? 385 GLN A NE2 1 ATOM 2529 N N . MET A 1 355 ? 59.360 -30.160 10.031 1.00 116.27 ? 386 MET A N 1 ATOM 2530 C CA . MET A 1 355 ? 59.998 -30.672 8.816 1.00 115.04 ? 386 MET A CA 1 ATOM 2531 C C . MET A 1 355 ? 61.497 -30.363 8.734 1.00 121.05 ? 386 MET A C 1 ATOM 2532 O O . MET A 1 355 ? 61.985 -29.443 9.396 1.00 128.68 ? 386 MET A O 1 ATOM 2533 C CB . MET A 1 355 ? 59.302 -30.105 7.584 1.00 112.11 ? 386 MET A CB 1 ATOM 2534 C CG . MET A 1 355 ? 57.909 -30.650 7.365 1.00 115.26 ? 386 MET A CG 1 ATOM 2535 S SD . MET A 1 355 ? 57.897 -32.451 7.425 1.00 120.51 ? 386 MET A SD 1 ATOM 2536 C CE . MET A 1 355 ? 56.764 -32.800 6.089 1.00 107.11 ? 386 MET A CE 1 ATOM 2537 N N . LYS A 1 356 ? 62.224 -31.112 7.905 1.00 117.59 ? 387 LYS A N 1 ATOM 2538 C CA . LYS A 1 356 ? 63.678 -30.934 7.810 1.00 117.04 ? 387 LYS A CA 1 ATOM 2539 C C . LYS A 1 356 ? 64.147 -30.004 6.688 1.00 114.08 ? 387 LYS A C 1 ATOM 2540 O O . LYS A 1 356 ? 65.227 -29.438 6.778 1.00 118.15 ? 387 LYS A O 1 ATOM 2541 C CB . LYS A 1 356 ? 64.406 -32.280 7.702 1.00 112.28 ? 387 LYS A CB 1 ATOM 2542 N N . TYR A 1 357 ? 63.351 -29.848 5.636 1.00 113.22 ? 388 TYR A N 1 ATOM 2543 C CA . TYR A 1 357 ? 63.781 -29.060 4.482 1.00 109.16 ? 388 TYR A CA 1 ATOM 2544 C C . TYR A 1 357 ? 62.892 -27.838 4.190 1.00 113.33 ? 388 TYR A C 1 ATOM 2545 O O . TYR A 1 357 ? 61.679 -27.856 4.416 1.00 113.51 ? 388 TYR A O 1 ATOM 2546 C CB . TYR A 1 357 ? 63.866 -29.957 3.246 1.00 108.61 ? 388 TYR A CB 1 ATOM 2547 C CG . TYR A 1 357 ? 64.855 -31.099 3.359 1.00 112.88 ? 388 TYR A CG 1 ATOM 2548 C CD1 . TYR A 1 357 ? 65.579 -31.526 2.256 1.00 112.08 ? 388 TYR A CD1 1 ATOM 2549 C CD2 . TYR A 1 357 ? 65.066 -31.750 4.566 1.00 119.10 ? 388 TYR A CD2 1 ATOM 2550 C CE1 . TYR A 1 357 ? 66.477 -32.576 2.346 1.00 112.79 ? 388 TYR A CE1 1 ATOM 2551 C CE2 . TYR A 1 357 ? 65.969 -32.800 4.674 1.00 117.99 ? 388 TYR A CE2 1 ATOM 2552 C CZ . TYR A 1 357 ? 66.670 -33.209 3.558 1.00 120.00 ? 388 TYR A CZ 1 ATOM 2553 O OH . TYR A 1 357 ? 67.565 -34.251 3.656 1.00 121.08 ? 388 TYR A OH 1 ATOM 2554 N N . TYR A 1 358 ? 63.503 -26.774 3.682 1.00 109.06 ? 389 TYR A N 1 ATOM 2555 C CA . TYR A 1 358 ? 62.746 -25.607 3.248 1.00 110.20 ? 389 TYR A CA 1 ATOM 2556 C C . TYR A 1 358 ? 62.389 -25.743 1.775 1.00 110.25 ? 389 TYR A C 1 ATOM 2557 O O . TYR A 1 358 ? 61.314 -25.320 1.335 1.00 103.68 ? 389 TYR A O 1 ATOM 2558 C CB . TYR A 1 358 ? 63.556 -24.334 3.469 1.00 113.97 ? 389 TYR A CB 1 ATOM 2559 C CG . TYR A 1 358 ? 63.285 -23.634 4.778 1.00 115.90 ? 389 TYR A CG 1 ATOM 2560 C CD1 . TYR A 1 358 ? 62.169 -22.821 4.932 1.00 111.05 ? 389 TYR A CD1 1 ATOM 2561 C CD2 . TYR A 1 358 ? 64.153 -23.770 5.853 1.00 117.48 ? 389 TYR A CD2 1 ATOM 2562 C CE1 . TYR A 1 358 ? 61.922 -22.175 6.120 1.00 116.06 ? 389 TYR A CE1 1 ATOM 2563 C CE2 . TYR A 1 358 ? 63.913 -23.129 7.044 1.00 119.23 ? 389 TYR A CE2 1 ATOM 2564 C CZ . TYR A 1 358 ? 62.798 -22.334 7.173 1.00 122.80 ? 389 TYR A CZ 1 ATOM 2565 O OH . TYR A 1 358 ? 62.555 -21.693 8.362 1.00 133.58 ? 389 TYR A OH 1 ATOM 2566 N N . VAL A 1 359 ? 63.319 -26.324 1.019 1.00 109.92 ? 390 VAL A N 1 ATOM 2567 C CA . VAL A 1 359 ? 63.083 -26.691 -0.373 1.00 111.03 ? 390 VAL A CA 1 ATOM 2568 C C . VAL A 1 359 ? 62.802 -28.192 -0.443 1.00 115.26 ? 390 VAL A C 1 ATOM 2569 O O . VAL A 1 359 ? 63.673 -29.009 -0.120 1.00 108.68 ? 390 VAL A O 1 ATOM 2570 C CB . VAL A 1 359 ? 64.303 -26.398 -1.259 1.00 100.35 ? 390 VAL A CB 1 ATOM 2571 C CG1 . VAL A 1 359 ? 63.895 -26.340 -2.716 1.00 96.07 ? 390 VAL A CG1 1 ATOM 2572 C CG2 . VAL A 1 359 ? 64.952 -25.108 -0.847 1.00 102.04 ? 390 VAL A CG2 1 ATOM 2573 N N . TRP A 1 360 ? 61.591 -28.561 -0.856 1.00 110.70 ? 391 TRP A N 1 ATOM 2574 C CA . TRP A 1 360 ? 61.261 -29.971 -0.986 1.00 106.66 ? 391 TRP A CA 1 ATOM 2575 C C . TRP A 1 360 ? 62.088 -30.614 -2.087 1.00 105.94 ? 391 TRP A C 1 ATOM 2576 O O . TRP A 1 360 ? 62.040 -30.164 -3.231 1.00 107.27 ? 391 TRP A O 1 ATOM 2577 C CB . TRP A 1 360 ? 59.777 -30.173 -1.277 1.00 109.72 ? 391 TRP A CB 1 ATOM 2578 C CG . TRP A 1 360 ? 59.423 -31.625 -1.240 1.00 112.21 ? 391 TRP A CG 1 ATOM 2579 C CD1 . TRP A 1 360 ? 59.212 -32.445 -2.308 1.00 112.40 ? 391 TRP A CD1 1 ATOM 2580 C CD2 . TRP A 1 360 ? 59.286 -32.445 -0.071 1.00 110.78 ? 391 TRP A CD2 1 ATOM 2581 N NE1 . TRP A 1 360 ? 58.938 -33.722 -1.876 1.00 114.52 ? 391 TRP A NE1 1 ATOM 2582 C CE2 . TRP A 1 360 ? 58.979 -33.746 -0.506 1.00 111.32 ? 391 TRP A CE2 1 ATOM 2583 C CE3 . TRP A 1 360 ? 59.383 -32.201 1.302 1.00 111.55 ? 391 TRP A CE3 1 ATOM 2584 C CZ2 . TRP A 1 360 ? 58.769 -34.801 0.381 1.00 111.53 ? 391 TRP A CZ2 1 ATOM 2585 C CZ3 . TRP A 1 360 ? 59.172 -33.246 2.180 1.00 113.22 ? 391 TRP A CZ3 1 ATOM 2586 C CH2 . TRP A 1 360 ? 58.871 -34.531 1.717 1.00 111.38 ? 391 TRP A CH2 1 ATOM 2587 N N . PRO A 1 361 ? 62.838 -31.678 -1.741 1.00 103.63 ? 392 PRO A N 1 ATOM 2588 C CA . PRO A 1 361 ? 63.803 -32.397 -2.592 1.00 102.61 ? 392 PRO A CA 1 ATOM 2589 C C . PRO A 1 361 ? 63.227 -32.991 -3.890 1.00 107.45 ? 392 PRO A C 1 ATOM 2590 O O . PRO A 1 361 ? 62.027 -33.226 -3.988 1.00 109.09 ? 392 PRO A O 1 ATOM 2591 C CB . PRO A 1 361 ? 64.297 -33.521 -1.679 1.00 93.01 ? 392 PRO A CB 1 ATOM 2592 C CG . PRO A 1 361 ? 64.052 -33.035 -0.305 1.00 94.53 ? 392 PRO A CG 1 ATOM 2593 C CD . PRO A 1 361 ? 62.809 -32.216 -0.370 1.00 99.78 ? 392 PRO A CD 1 ATOM 2594 N N . ARG A 1 362 ? 64.085 -33.210 -4.886 1.00 108.52 ? 393 ARG A N 1 ATOM 2595 C CA . ARG A 1 362 ? 63.688 -33.904 -6.112 1.00 111.93 ? 393 ARG A CA 1 ATOM 2596 C C . ARG A 1 362 ? 64.503 -35.186 -6.268 1.00 125.85 ? 393 ARG A C 1 ATOM 2597 O O . ARG A 1 362 ? 65.739 -35.163 -6.234 1.00 118.57 ? 393 ARG A O 1 ATOM 2598 C CB . ARG A 1 362 ? 63.847 -33.023 -7.354 1.00 95.92 ? 393 ARG A CB 1 ATOM 2599 N N . MET A 1 363 ? 63.797 -36.304 -6.434 1.00 137.71 ? 394 MET A N 1 ATOM 2600 C CA . MET A 1 363 ? 64.434 -37.614 -6.548 1.00 137.38 ? 394 MET A CA 1 ATOM 2601 C C . MET A 1 363 ? 64.379 -38.153 -7.980 1.00 142.38 ? 394 MET A C 1 ATOM 2602 O O . MET A 1 363 ? 65.352 -38.055 -8.737 1.00 142.94 ? 394 MET A O 1 ATOM 2603 C CB . MET A 1 363 ? 63.785 -38.609 -5.578 1.00 126.93 ? 394 MET A CB 1 ATOM 2604 C CG . MET A 1 363 ? 63.760 -38.151 -4.120 1.00 124.17 ? 394 MET A CG 1 ATOM 2605 S SD . MET A 1 363 ? 65.407 -37.818 -3.459 1.00 145.30 ? 394 MET A SD 1 ATOM 2606 C CE . MET A 1 363 ? 65.065 -37.634 -1.706 1.00 124.61 ? 394 MET A CE 1 HETATM 2607 C C1 . NAG B 2 . ? 62.130 -72.545 11.195 1.00 175.35 ? 501 NAG A C1 1 HETATM 2608 C C2 . NAG B 2 . ? 61.741 -72.909 9.753 1.00 180.21 ? 501 NAG A C2 1 HETATM 2609 C C3 . NAG B 2 . ? 61.342 -74.385 9.676 1.00 185.01 ? 501 NAG A C3 1 HETATM 2610 C C4 . NAG B 2 . ? 62.443 -75.245 10.282 1.00 190.19 ? 501 NAG A C4 1 HETATM 2611 C C5 . NAG B 2 . ? 62.666 -74.832 11.732 1.00 186.73 ? 501 NAG A C5 1 HETATM 2612 C C6 . NAG B 2 . ? 63.539 -75.787 12.543 1.00 178.57 ? 501 NAG A C6 1 HETATM 2613 C C7 . NAG B 2 . ? 61.291 -70.807 8.448 1.00 176.08 ? 501 NAG A C7 1 HETATM 2614 C C8 . NAG B 2 . ? 60.305 -69.843 7.791 1.00 170.57 ? 501 NAG A C8 1 HETATM 2615 N N2 . NAG B 2 . ? 60.803 -71.993 9.128 1.00 180.77 ? 501 NAG A N2 1 HETATM 2616 O O3 . NAG B 2 . ? 60.892 -74.807 8.416 1.00 181.30 ? 501 NAG A O3 1 HETATM 2617 O O4 . NAG B 2 . ? 62.294 -76.625 10.078 1.00 186.26 ? 501 NAG A O4 1 HETATM 2618 O O5 . NAG B 2 . ? 63.067 -73.462 11.786 1.00 180.27 ? 501 NAG A O5 1 HETATM 2619 O O6 . NAG B 2 . ? 64.245 -76.774 11.844 1.00 178.22 ? 501 NAG A O6 1 HETATM 2620 O O7 . NAG B 2 . ? 62.454 -70.588 8.401 1.00 166.77 ? 501 NAG A O7 1 HETATM 2621 C C1 . NAG C 2 . ? 42.631 -40.880 32.816 1.00 179.49 ? 502 NAG A C1 1 HETATM 2622 C C2 . NAG C 2 . ? 43.602 -40.031 33.656 1.00 189.24 ? 502 NAG A C2 1 HETATM 2623 C C3 . NAG C 2 . ? 43.106 -39.959 35.102 1.00 194.20 ? 502 NAG A C3 1 HETATM 2624 C C4 . NAG C 2 . ? 41.662 -39.477 35.120 1.00 188.22 ? 502 NAG A C4 1 HETATM 2625 C C5 . NAG C 2 . ? 40.801 -40.446 34.321 1.00 184.33 ? 502 NAG A C5 1 HETATM 2626 C C6 . NAG C 2 . ? 39.297 -40.243 34.484 1.00 184.77 ? 502 NAG A C6 1 HETATM 2627 C C7 . NAG C 2 . ? 46.027 -39.558 34.126 1.00 197.79 ? 502 NAG A C7 1 HETATM 2628 C C8 . NAG C 2 . ? 47.498 -39.942 33.991 1.00 182.36 ? 502 NAG A C8 1 HETATM 2629 N N2 . NAG C 2 . ? 45.002 -40.387 33.518 1.00 194.90 ? 502 NAG A N2 1 HETATM 2630 O O3 . NAG C 2 . ? 43.957 -39.286 35.989 1.00 191.28 ? 502 NAG A O3 1 HETATM 2631 O O4 . NAG C 2 . ? 41.168 -39.161 36.391 1.00 181.93 ? 502 NAG A O4 1 HETATM 2632 O O5 . NAG C 2 . ? 41.256 -40.493 32.967 1.00 182.66 ? 502 NAG A O5 1 HETATM 2633 O O6 . NAG C 2 . ? 38.869 -39.119 35.200 1.00 183.69 ? 502 NAG A O6 1 HETATM 2634 O O7 . NAG C 2 . ? 45.727 -38.572 34.707 1.00 201.10 ? 502 NAG A O7 1 HETATM 2635 CL CL . CL D 3 . ? 49.207 -47.820 10.047 1.00 112.10 ? 601 CL A CL 1 HETATM 2636 CL CL . CL E 3 . ? 61.960 -53.475 31.637 1.00 110.35 ? 602 CL A CL 1 HETATM 2637 CL CL . CL F 3 . ? 35.338 -47.804 5.890 0.68 114.10 ? 603 CL A CL 1 HETATM 2638 CL CL . CL G 3 . ? 63.241 -35.401 10.569 0.85 122.63 ? 604 CL A CL 1 HETATM 2639 CL CL . CL H 3 . ? 55.093 -60.456 4.887 0.76 113.92 ? 605 CL A CL 1 HETATM 2640 NA NA . NA I 4 . ? 49.747 -48.495 13.761 1.00 123.10 ? 701 NA A NA 1 HETATM 2641 ZN ZN . ZN J 5 . ? 60.654 -52.335 14.272 0.46 132.81 ? 901 ZN A ZN 1 HETATM 2642 ZN ZN . ZN K 5 . ? 48.551 -35.574 21.464 0.31 134.15 ? 902 ZN A ZN 1 HETATM 2643 ZN ZN . ZN L 5 . ? 62.015 -47.594 35.864 1.00 152.45 ? 903 ZN A ZN 1 HETATM 2644 ZN ZN . ZN M 5 . ? 52.358 -23.991 7.025 1.00 155.17 ? 904 ZN A ZN 1 HETATM 2645 ZN ZN . ZN N 5 . ? 34.161 -52.372 42.712 0.23 133.79 ? 905 ZN A ZN 1 HETATM 2646 O O . HOH O 6 . ? 51.401 -49.769 41.108 1.00 112.46 ? 1 HOH A O 1 HETATM 2647 O O . HOH O 6 . ? 58.541 -36.647 -2.956 1.00 101.65 ? 2 HOH A O 1 HETATM 2648 O O . HOH O 6 . ? 48.318 -59.668 5.020 1.00 103.35 ? 3 HOH A O 1 HETATM 2649 O O . HOH O 6 . ? 37.045 -59.910 9.927 1.00 106.05 ? 4 HOH A O 1 HETATM 2650 O O . HOH O 6 . ? 42.470 -63.390 30.882 1.00 121.26 ? 5 HOH A O 1 HETATM 2651 O O . HOH O 6 . ? 32.642 -64.818 23.260 1.00 106.07 ? 6 HOH A O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 PRO 1 32 32 PRO PRO A . n A 1 2 PRO 2 33 33 PRO PRO A . n A 1 3 SER 3 34 34 SER SER A . n A 1 4 ILE 4 35 35 ILE ILE A . n A 1 5 GLY 5 36 36 GLY GLY A . n A 1 6 ILE 6 37 37 ILE ILE A . n A 1 7 ALA 7 38 38 ALA ALA A . n A 1 8 VAL 8 39 39 VAL VAL A . n A 1 9 ILE 9 40 40 ILE ILE A . n A 1 10 LEU 10 41 41 LEU LEU A . n A 1 11 VAL 11 42 42 VAL VAL A . n A 1 12 GLY 12 43 43 GLY GLY A . n A 1 13 THR 13 44 44 THR THR A . n A 1 14 SER 14 45 45 SER SER A . n A 1 15 ASP 15 46 46 ASP ASP A . n A 1 16 GLU 16 47 47 GLU GLU A . n A 1 17 VAL 17 48 48 VAL VAL A . n A 1 18 ALA 18 49 49 ALA ALA A . n A 1 19 ILE 19 50 50 ILE ILE A . n A 1 20 LYS 20 51 51 LYS LYS A . n A 1 21 ASP 21 52 52 ASP ASP A . n A 1 22 ALA 22 53 53 ALA ALA A . n A 1 23 HIS 23 54 54 HIS HIS A . n A 1 24 GLU 24 55 55 GLU GLU A . n A 1 25 LYS 25 56 56 LYS LYS A . n A 1 26 ASP 26 57 57 ASP ASP A . n A 1 27 ASP 27 58 58 ASP ASP A . n A 1 28 PHE 28 59 59 PHE PHE A . n A 1 29 HIS 29 60 60 HIS HIS A . n A 1 30 HIS 30 61 61 HIS HIS A . n A 1 31 LEU 31 62 62 LEU LEU A . n A 1 32 SER 32 63 63 SER SER A . n A 1 33 VAL 33 64 64 VAL VAL A . n A 1 34 VAL 34 65 65 VAL VAL A . n A 1 35 PRO 35 66 66 PRO PRO A . n A 1 36 ARG 36 67 67 ARG ARG A . n A 1 37 VAL 37 68 68 VAL VAL A . n A 1 38 GLU 38 69 69 GLU GLU A . n A 1 39 LEU 39 70 70 LEU LEU A . n A 1 40 VAL 40 71 71 VAL VAL A . n A 1 41 ALA 41 72 72 ALA ALA A . n A 1 42 MET 42 73 73 MET MET A . n A 1 43 ASN 43 74 74 ASN ASN A . n A 1 44 GLU 44 75 75 GLU GLU A . n A 1 45 THR 45 76 76 THR THR A . n A 1 46 ASP 46 77 77 ASP ASP A . n A 1 47 PRO 47 78 78 PRO PRO A . n A 1 48 LYS 48 79 79 LYS LYS A . n A 1 49 SER 49 80 80 SER SER A . n A 1 50 ILE 50 81 81 ILE ILE A . n A 1 51 ILE 51 82 82 ILE ILE A . n A 1 52 THR 52 83 83 THR THR A . n A 1 53 ARG 53 84 84 ARG ARG A . n A 1 54 ILE 54 85 85 ILE ILE A . n A 1 55 CYS 55 86 86 CYS CYS A . n A 1 56 ASP 56 87 87 ASP ASP A . n A 1 57 LEU 57 88 88 LEU LEU A . n A 1 58 MET 58 89 89 MET MET A . n A 1 59 SER 59 90 90 SER SER A . n A 1 60 ASP 60 91 91 ASP ASP A . n A 1 61 ARG 61 92 92 ARG ARG A . n A 1 62 LYS 62 93 93 LYS LYS A . n A 1 63 ILE 63 94 94 ILE ILE A . n A 1 64 GLN 64 95 95 GLN GLN A . n A 1 65 GLY 65 96 96 GLY GLY A . n A 1 66 VAL 66 97 97 VAL VAL A . n A 1 67 VAL 67 98 98 VAL VAL A . n A 1 68 PHE 68 99 99 PHE PHE A . n A 1 69 ALA 69 100 100 ALA ALA A . n A 1 70 ASP 70 101 101 ASP ASP A . n A 1 71 ASP 71 102 102 ASP ASP A . n A 1 72 THR 72 103 103 THR THR A . n A 1 73 ASP 73 104 104 ASP ASP A . n A 1 74 GLN 74 105 105 GLN GLN A . n A 1 75 GLU 75 106 106 GLU GLU A . n A 1 76 ALA 76 107 107 ALA ALA A . n A 1 77 ILE 77 108 108 ILE ILE A . n A 1 78 ALA 78 109 109 ALA ALA A . n A 1 79 GLN 79 110 110 GLN GLN A . n A 1 80 ILE 80 111 111 ILE ILE A . n A 1 81 LEU 81 112 112 LEU LEU A . n A 1 82 ASP 82 113 113 ASP ASP A . n A 1 83 PHE 83 114 114 PHE PHE A . n A 1 84 ILE 84 115 115 ILE ILE A . n A 1 85 SER 85 116 116 SER SER A . n A 1 86 ALA 86 117 117 ALA ALA A . n A 1 87 GLN 87 118 118 GLN GLN A . n A 1 88 THR 88 119 119 THR THR A . n A 1 89 LEU 89 120 120 LEU LEU A . n A 1 90 THR 90 121 121 THR THR A . n A 1 91 PRO 91 122 122 PRO PRO A . n A 1 92 ILE 92 123 123 ILE ILE A . n A 1 93 LEU 93 124 124 LEU LEU A . n A 1 94 GLY 94 125 125 GLY GLY A . n A 1 95 ILE 95 126 126 ILE ILE A . n A 1 96 HIS 96 127 127 HIS HIS A . n A 1 97 GLY 97 128 128 GLY GLY A . n A 1 98 GLY 98 129 129 GLY GLY A . n A 1 99 SER 99 130 130 SER SER A . n A 1 100 SER 100 131 131 SER SER A . n A 1 101 MET 101 132 132 MET MET A . n A 1 102 ILE 102 133 133 ILE ILE A . n A 1 103 MET 103 134 134 MET MET A . n A 1 104 ALA 104 135 135 ALA ALA A . n A 1 105 ASP 105 136 136 ASP ASP A . n A 1 106 LYS 106 137 137 LYS LYS A . n A 1 107 ASP 107 138 138 ASP ASP A . n A 1 108 GLU 108 139 139 GLU GLU A . n A 1 109 SER 109 140 140 SER SER A . n A 1 110 SER 110 141 141 SER SER A . n A 1 111 MET 111 142 142 MET MET A . n A 1 112 PHE 112 143 143 PHE PHE A . n A 1 113 PHE 113 144 144 PHE PHE A . n A 1 114 GLN 114 145 145 GLN GLN A . n A 1 115 PHE 115 146 146 PHE PHE A . n A 1 116 GLY 116 147 147 GLY GLY A . n A 1 117 PRO 117 148 148 PRO PRO A . n A 1 118 SER 118 149 149 SER SER A . n A 1 119 ILE 119 150 150 ILE ILE A . n A 1 120 GLU 120 151 151 GLU GLU A . n A 1 121 GLN 121 152 152 GLN GLN A . n A 1 122 GLN 122 153 153 GLN GLN A . n A 1 123 ALA 123 154 154 ALA ALA A . n A 1 124 SER 124 155 155 SER SER A . n A 1 125 VAL 125 156 156 VAL VAL A . n A 1 126 MET 126 157 157 MET MET A . n A 1 127 LEU 127 158 158 LEU LEU A . n A 1 128 ASN 128 159 159 ASN ASN A . n A 1 129 ILE 129 160 160 ILE ILE A . n A 1 130 MET 130 161 161 MET MET A . n A 1 131 GLU 131 162 162 GLU GLU A . n A 1 132 GLU 132 163 163 GLU GLU A . n A 1 133 TYR 133 164 164 TYR TYR A . n A 1 134 ASP 134 165 165 ASP ASP A . n A 1 135 TRP 135 166 166 TRP TRP A . n A 1 136 TYR 136 167 167 TYR TYR A . n A 1 137 ILE 137 168 168 ILE ILE A . n A 1 138 PHE 138 169 169 PHE PHE A . n A 1 139 SER 139 170 170 SER SER A . n A 1 140 ILE 140 171 171 ILE ILE A . n A 1 141 VAL 141 172 172 VAL VAL A . n A 1 142 THR 142 173 173 THR THR A . n A 1 143 THR 143 174 174 THR THR A . n A 1 144 TYR 144 175 175 TYR TYR A . n A 1 145 PHE 145 176 176 PHE PHE A . n A 1 146 PRO 146 177 177 PRO PRO A . n A 1 147 GLY 147 178 178 GLY GLY A . n A 1 148 TYR 148 179 179 TYR TYR A . n A 1 149 GLN 149 180 180 GLN GLN A . n A 1 150 ASP 150 181 181 ASP ASP A . n A 1 151 PHE 151 182 182 PHE PHE A . n A 1 152 VAL 152 183 183 VAL VAL A . n A 1 153 ASN 153 184 184 ASN ASN A . n A 1 154 LYS 154 185 185 LYS LYS A . n A 1 155 ILE 155 186 186 ILE ILE A . n A 1 156 ARG 156 187 187 ARG ARG A . n A 1 157 SER 157 188 188 SER SER A . n A 1 158 THR 158 189 189 THR THR A . n A 1 159 ILE 159 190 190 ILE ILE A . n A 1 160 GLU 160 191 191 GLU GLU A . n A 1 161 ASN 161 192 192 ASN ASN A . n A 1 162 SER 162 193 193 SER SER A . n A 1 163 PHE 163 194 194 PHE PHE A . n A 1 164 VAL 164 195 195 VAL VAL A . n A 1 165 GLY 165 196 196 GLY GLY A . n A 1 166 TRP 166 197 197 TRP TRP A . n A 1 167 GLU 167 198 198 GLU GLU A . n A 1 168 LEU 168 199 199 LEU LEU A . n A 1 169 GLU 169 200 200 GLU GLU A . n A 1 170 GLU 170 201 201 GLU GLU A . n A 1 171 VAL 171 202 202 VAL VAL A . n A 1 172 LEU 172 203 203 LEU LEU A . n A 1 173 LEU 173 204 204 LEU LEU A . n A 1 174 LEU 174 205 205 LEU LEU A . n A 1 175 ASP 175 206 206 ASP ASP A . n A 1 176 MET 176 207 207 MET MET A . n A 1 177 SER 177 208 208 SER SER A . n A 1 178 LEU 178 209 ? ? ? A . n A 1 179 ASP 179 210 ? ? ? A . n A 1 180 ASP 180 211 ? ? ? A . n A 1 181 GLY 181 212 ? ? ? A . n A 1 182 ASP 182 213 ? ? ? A . n A 1 183 SER 183 214 214 SER SER A . n A 1 184 LYS 184 215 215 LYS LYS A . n A 1 185 ILE 185 216 216 ILE ILE A . n A 1 186 GLN 186 217 217 GLN GLN A . n A 1 187 ASN 187 218 218 ASN ASN A . n A 1 188 GLN 188 219 219 GLN GLN A . n A 1 189 LEU 189 220 220 LEU LEU A . n A 1 190 LYS 190 221 221 LYS LYS A . n A 1 191 LYS 191 222 222 LYS LYS A . n A 1 192 LEU 192 223 223 LEU LEU A . n A 1 193 GLN 193 224 224 GLN GLN A . n A 1 194 SER 194 225 225 SER SER A . n A 1 195 PRO 195 226 226 PRO PRO A . n A 1 196 ILE 196 227 227 ILE ILE A . n A 1 197 ILE 197 228 228 ILE ILE A . n A 1 198 LEU 198 229 229 LEU LEU A . n A 1 199 LEU 199 230 230 LEU LEU A . n A 1 200 TYR 200 231 231 TYR TYR A . n A 1 201 CYS 201 232 232 CYS CYS A . n A 1 202 THR 202 233 233 THR THR A . n A 1 203 LYS 203 234 234 LYS LYS A . n A 1 204 GLU 204 235 235 GLU GLU A . n A 1 205 GLU 205 236 236 GLU GLU A . n A 1 206 ALA 206 237 237 ALA ALA A . n A 1 207 THR 207 238 238 THR THR A . n A 1 208 TYR 208 239 239 TYR TYR A . n A 1 209 ILE 209 240 240 ILE ILE A . n A 1 210 PHE 210 241 241 PHE PHE A . n A 1 211 GLU 211 242 242 GLU GLU A . n A 1 212 VAL 212 243 243 VAL VAL A . n A 1 213 ALA 213 244 244 ALA ALA A . n A 1 214 ASN 214 245 245 ASN ASN A . n A 1 215 SER 215 246 246 SER SER A . n A 1 216 VAL 216 247 247 VAL VAL A . n A 1 217 GLY 217 248 248 GLY GLY A . n A 1 218 LEU 218 249 249 LEU LEU A . n A 1 219 THR 219 250 250 THR THR A . n A 1 220 GLY 220 251 251 GLY GLY A . n A 1 221 TYR 221 252 252 TYR TYR A . n A 1 222 GLY 222 253 253 GLY GLY A . n A 1 223 TYR 223 254 254 TYR TYR A . n A 1 224 THR 224 255 255 THR THR A . n A 1 225 TRP 225 256 256 TRP TRP A . n A 1 226 ILE 226 257 257 ILE ILE A . n A 1 227 VAL 227 258 258 VAL VAL A . n A 1 228 PRO 228 259 259 PRO PRO A . n A 1 229 SER 229 260 260 SER SER A . n A 1 230 LEU 230 261 261 LEU LEU A . n A 1 231 VAL 231 262 262 VAL VAL A . n A 1 232 ALA 232 263 263 ALA ALA A . n A 1 233 GLY 233 264 264 GLY GLY A . n A 1 234 ASP 234 265 265 ASP ASP A . n A 1 235 THR 235 266 266 THR THR A . n A 1 236 ASP 236 267 267 ASP ASP A . n A 1 237 THR 237 268 268 THR THR A . n A 1 238 VAL 238 269 269 VAL VAL A . n A 1 239 PRO 239 270 270 PRO PRO A . n A 1 240 SER 240 271 271 SER SER A . n A 1 241 GLU 241 272 272 GLU GLU A . n A 1 242 PHE 242 273 273 PHE PHE A . n A 1 243 PRO 243 274 274 PRO PRO A . n A 1 244 THR 244 275 275 THR THR A . n A 1 245 GLY 245 276 276 GLY GLY A . n A 1 246 LEU 246 277 277 LEU LEU A . n A 1 247 ILE 247 278 278 ILE ILE A . n A 1 248 SER 248 279 279 SER SER A . n A 1 249 VAL 249 280 280 VAL VAL A . n A 1 250 SER 250 281 281 SER ALA A . n A 1 251 TYR 251 282 282 TYR TYR A . n A 1 252 ASP 252 283 283 ASP ASP A . n A 1 253 GLU 253 284 284 GLU GLU A . n A 1 254 TRP 254 285 285 TRP ALA A . n A 1 255 ASP 255 286 286 ASP ALA A . n A 1 256 TYR 256 287 287 TYR TYR A . n A 1 257 GLY 257 288 288 GLY GLY A . n A 1 258 LEU 258 289 289 LEU LEU A . n A 1 259 PRO 259 290 290 PRO PRO A . n A 1 260 ALA 260 291 291 ALA ALA A . n A 1 261 ARG 261 292 292 ARG ARG A . n A 1 262 VAL 262 293 293 VAL VAL A . n A 1 263 ARG 263 294 294 ARG ARG A . n A 1 264 ASP 264 295 295 ASP ASP A . n A 1 265 GLY 265 296 296 GLY GLY A . n A 1 266 ILE 266 297 297 ILE ILE A . n A 1 267 ALA 267 298 298 ALA ALA A . n A 1 268 ILE 268 299 299 ILE ILE A . n A 1 269 ILE 269 300 300 ILE ILE A . n A 1 270 THR 270 301 301 THR THR A . n A 1 271 THR 271 302 302 THR THR A . n A 1 272 ALA 272 303 303 ALA ALA A . n A 1 273 ALA 273 304 304 ALA ALA A . n A 1 274 SER 274 305 305 SER SER A . n A 1 275 ASP 275 306 306 ASP ASP A . n A 1 276 MET 276 307 307 MET MET A . n A 1 277 LEU 277 308 308 LEU LEU A . n A 1 278 SER 278 309 309 SER SER A . n A 1 279 GLU 279 310 310 GLU GLU A . n A 1 280 HIS 280 311 311 HIS HIS A . n A 1 281 SER 281 312 312 SER SER A . n A 1 282 PHE 282 313 313 PHE PHE A . n A 1 283 ILE 283 314 314 ILE ILE A . n A 1 284 PRO 284 315 315 PRO PRO A . n A 1 285 GLU 285 316 316 GLU GLU A . n A 1 286 PRO 286 317 317 PRO PRO A . n A 1 287 LYS 287 318 318 LYS LYS A . n A 1 288 SER 288 319 319 SER SER A . n A 1 289 SER 289 320 320 SER SER A . n A 1 290 CYS 290 321 321 CYS CYS A . n A 1 291 TYR 291 322 322 TYR TYR A . n A 1 292 ASN 292 323 323 ASN ASN A . n A 1 293 THR 293 324 324 THR THR A . n A 1 294 HIS 294 325 325 HIS ALA A . n A 1 295 GLU 295 326 326 GLU GLU A . n A 1 296 LYS 296 327 327 LYS LYS A . n A 1 297 ARG 297 328 328 ARG ARG A . n A 1 298 ILE 298 329 329 ILE ILE A . n A 1 299 TYR 299 330 330 TYR TYR A . n A 1 300 GLN 300 331 331 GLN GLN A . n A 1 301 SER 301 332 332 SER SER A . n A 1 302 ASN 302 333 333 ASN ASN A . n A 1 303 MET 303 334 334 MET MET A . n A 1 304 LEU 304 335 335 LEU LEU A . n A 1 305 ASN 305 336 336 ASN ASN A . n A 1 306 ARG 306 337 337 ARG ARG A . n A 1 307 TYR 307 338 338 TYR TYR A . n A 1 308 LEU 308 339 339 LEU LEU A . n A 1 309 ILE 309 340 340 ILE ILE A . n A 1 310 ASN 310 341 341 ASN ASN A . n A 1 311 VAL 311 342 342 VAL VAL A . n A 1 312 THR 312 343 343 THR THR A . n A 1 313 PHE 313 344 344 PHE PHE A . n A 1 314 GLU 314 345 345 GLU GLU A . n A 1 315 GLY 315 346 346 GLY GLY A . n A 1 316 ARG 316 347 347 ARG ARG A . n A 1 317 ASP 317 348 348 ASP ASP A . n A 1 318 LEU 318 349 349 LEU LEU A . n A 1 319 SER 319 350 350 SER SER A . n A 1 320 PHE 320 351 351 PHE PHE A . n A 1 321 SER 321 352 352 SER SER A . n A 1 322 GLU 322 353 353 GLU GLU A . n A 1 323 ASP 323 354 354 ASP ASP A . n A 1 324 GLY 324 355 355 GLY GLY A . n A 1 325 TYR 325 356 356 TYR TYR A . n A 1 326 GLN 326 357 357 GLN GLN A . n A 1 327 MET 327 358 358 MET MET A . n A 1 328 HIS 328 359 359 HIS HIS A . n A 1 329 PRO 329 360 360 PRO PRO A . n A 1 330 LYS 330 361 361 LYS ALA A . n A 1 331 LEU 331 362 362 LEU LEU A . n A 1 332 VAL 332 363 363 VAL VAL A . n A 1 333 ILE 333 364 364 ILE ILE A . n A 1 334 ILE 334 365 365 ILE ILE A . n A 1 335 LEU 335 366 366 LEU LEU A . n A 1 336 LEU 336 367 367 LEU LEU A . n A 1 337 ASN 337 368 368 ASN ASN A . n A 1 338 LYS 338 369 369 LYS LYS A . n A 1 339 GLU 339 370 370 GLU GLU A . n A 1 340 ARG 340 371 371 ARG ARG A . n A 1 341 LYS 341 372 372 LYS LYS A . n A 1 342 TRP 342 373 373 TRP TRP A . n A 1 343 GLU 343 374 374 GLU GLU A . n A 1 344 ARG 344 375 375 ARG ARG A . n A 1 345 VAL 345 376 376 VAL VAL A . n A 1 346 GLY 346 377 377 GLY GLY A . n A 1 347 LYS 347 378 378 LYS LYS A . n A 1 348 TRP 348 379 379 TRP TRP A . n A 1 349 LYS 349 380 380 LYS LYS A . n A 1 350 ASP 350 381 381 ASP ASP A . n A 1 351 LYS 351 382 382 LYS ALA A . n A 1 352 SER 352 383 383 SER SER A . n A 1 353 LEU 353 384 384 LEU LEU A . n A 1 354 GLN 354 385 385 GLN GLN A . n A 1 355 MET 355 386 386 MET MET A . n A 1 356 LYS 356 387 387 LYS LYS A . n A 1 357 TYR 357 388 388 TYR TYR A . n A 1 358 TYR 358 389 389 TYR TYR A . n A 1 359 VAL 359 390 390 VAL VAL A . n A 1 360 TRP 360 391 391 TRP TRP A . n A 1 361 PRO 361 392 392 PRO PRO A . n A 1 362 ARG 362 393 393 ARG ARG A . n A 1 363 MET 363 394 394 MET MET A . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code B 2 NAG 1 501 501 NAG NAG A . C 2 NAG 1 502 502 NAG NAG A . D 3 CL 1 601 601 CL CL A . E 3 CL 1 602 602 CL CL A . F 3 CL 1 603 603 CL CL A . G 3 CL 1 604 604 CL CL A . H 3 CL 1 605 605 CL CL A . I 4 NA 1 701 701 NA NA A . J 5 ZN 1 901 901 ZN ZN A . K 5 ZN 1 902 902 ZN ZN A . L 5 ZN 1 903 903 ZN ZN A . M 5 ZN 1 904 904 ZN ZN A . N 5 ZN 1 905 905 ZN ZN A . O 6 HOH 1 1 1 HOH HOH A . O 6 HOH 2 2 2 HOH HOH A . O 6 HOH 3 3 3 HOH HOH A . O 6 HOH 4 4 4 HOH HOH A . O 6 HOH 5 5 5 HOH HOH A . O 6 HOH 6 6 6 HOH HOH A . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 43 A ASN 74 ? ASN 'GLYCOSYLATION SITE' 2 A ASN 310 A ASN 341 ? ASN 'GLYCOSYLATION SITE' # loop_ _pdbx_struct_assembly.id _pdbx_struct_assembly.details _pdbx_struct_assembly.method_details _pdbx_struct_assembly.oligomeric_details _pdbx_struct_assembly.oligomeric_count 1 author_defined_assembly ? monomeric 1 2 software_defined_assembly PISA dimeric 2 # loop_ _pdbx_struct_assembly_gen.assembly_id _pdbx_struct_assembly_gen.oper_expression _pdbx_struct_assembly_gen.asym_id_list 1 1 A,B,C,D,E,F,G,H,I,J,K,L,M,N,O 2 1,2 A,B,C,D,E,F,G,H,I,J,K,L,M,N,O # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 2 'ABSA (A^2)' 4780 ? 2 MORE -375 ? 2 'SSA (A^2)' 29850 ? # loop_ _pdbx_struct_oper_list.id _pdbx_struct_oper_list.type _pdbx_struct_oper_list.name _pdbx_struct_oper_list.symmetry_operation _pdbx_struct_oper_list.matrix[1][1] _pdbx_struct_oper_list.matrix[1][2] _pdbx_struct_oper_list.matrix[1][3] _pdbx_struct_oper_list.vector[1] _pdbx_struct_oper_list.matrix[2][1] _pdbx_struct_oper_list.matrix[2][2] _pdbx_struct_oper_list.matrix[2][3] _pdbx_struct_oper_list.vector[2] _pdbx_struct_oper_list.matrix[3][1] _pdbx_struct_oper_list.matrix[3][2] _pdbx_struct_oper_list.matrix[3][3] _pdbx_struct_oper_list.vector[3] 1 'identity operation' 1_555 x,y,z 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 2 'crystal symmetry operation' 6_555 -x,-x+y,-z+1/3 -0.5000000000 -0.8660254038 0.0000000000 0.0000000000 -0.8660254038 0.5000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 29.4890000000 # loop_ _pdbx_struct_conn_angle.id _pdbx_struct_conn_angle.ptnr1_label_atom_id _pdbx_struct_conn_angle.ptnr1_label_alt_id _pdbx_struct_conn_angle.ptnr1_label_asym_id _pdbx_struct_conn_angle.ptnr1_label_comp_id _pdbx_struct_conn_angle.ptnr1_label_seq_id _pdbx_struct_conn_angle.ptnr1_auth_atom_id _pdbx_struct_conn_angle.ptnr1_auth_asym_id _pdbx_struct_conn_angle.ptnr1_auth_comp_id _pdbx_struct_conn_angle.ptnr1_auth_seq_id _pdbx_struct_conn_angle.ptnr1_PDB_ins_code _pdbx_struct_conn_angle.ptnr1_symmetry _pdbx_struct_conn_angle.ptnr2_label_atom_id _pdbx_struct_conn_angle.ptnr2_label_alt_id _pdbx_struct_conn_angle.ptnr2_label_asym_id _pdbx_struct_conn_angle.ptnr2_label_comp_id _pdbx_struct_conn_angle.ptnr2_label_seq_id _pdbx_struct_conn_angle.ptnr2_auth_atom_id _pdbx_struct_conn_angle.ptnr2_auth_asym_id _pdbx_struct_conn_angle.ptnr2_auth_comp_id _pdbx_struct_conn_angle.ptnr2_auth_seq_id _pdbx_struct_conn_angle.ptnr2_PDB_ins_code _pdbx_struct_conn_angle.ptnr2_symmetry _pdbx_struct_conn_angle.ptnr3_label_atom_id _pdbx_struct_conn_angle.ptnr3_label_alt_id _pdbx_struct_conn_angle.ptnr3_label_asym_id _pdbx_struct_conn_angle.ptnr3_label_comp_id _pdbx_struct_conn_angle.ptnr3_label_seq_id _pdbx_struct_conn_angle.ptnr3_auth_atom_id _pdbx_struct_conn_angle.ptnr3_auth_asym_id _pdbx_struct_conn_angle.ptnr3_auth_comp_id _pdbx_struct_conn_angle.ptnr3_auth_seq_id _pdbx_struct_conn_angle.ptnr3_PDB_ins_code _pdbx_struct_conn_angle.ptnr3_symmetry _pdbx_struct_conn_angle.value _pdbx_struct_conn_angle.value_esd 1 ND1 ? A HIS 29 ? A HIS 60 ? 1_555 ZN ? L ZN . ? A ZN 903 ? 1_555 OE1 ? A GLU 314 ? A GLU 345 ? 1_555 87.3 ? 2 NE2 ? A HIS 96 ? A HIS 127 ? 1_555 ZN ? J ZN . ? A ZN 901 ? 1_555 OE2 ? A GLU 253 ? A GLU 284 ? 1_555 115.0 ? 3 O ? A SER 100 ? A SER 131 ? 1_555 NA ? I NA . ? A NA 701 ? 1_555 O ? A PHE 115 ? A PHE 146 ? 1_555 97.4 ? 4 OE1 ? A GLU 131 ? A GLU 162 ? 1_555 ZN ? M ZN . ? A ZN 904 ? 1_555 OE2 ? A GLU 132 ? A GLU 163 ? 1_555 131.7 ? 5 ND1 ? A HIS 328 ? A HIS 359 ? 1_555 ZN ? K ZN . ? A ZN 902 ? 1_555 OD1 ? A ASP 350 ? A ASP 381 ? 1_555 117.2 ? 6 ND1 ? A HIS 328 ? A HIS 359 ? 1_555 ZN ? K ZN . ? A ZN 902 ? 1_555 OD2 ? A ASP 350 ? A ASP 381 ? 1_555 101.7 ? 7 OD1 ? A ASP 350 ? A ASP 381 ? 1_555 ZN ? K ZN . ? A ZN 902 ? 1_555 OD2 ? A ASP 350 ? A ASP 381 ? 1_555 61.6 ? # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2009-12-08 2 'Structure model' 1 1 2011-07-13 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Non-polymer description' 2 2 'Structure model' 'Version format compliance' # loop_ _software.pdbx_ordinal _software.name _software.version _software.date _software.type _software.contact_author _software.contact_author_email _software.classification _software.location _software.language _software.citation_id 1 PHENIX ? ? package 'Paul D. Adams' PDAdams@lbl.gov refinement http://www.phenix-online.org/ C++ ? 2 PDB_EXTRACT 3.005 'June 11, 2008' package PDB help@deposit.rcsb.org 'data extraction' http://sw-tools.pdb.org/apps/PDB_EXTRACT/ C++ ? 3 HKL-2000 . ? ? ? ? 'data collection' ? ? ? 4 HKL-2000 . ? ? ? ? 'data reduction' ? ? ? 5 HKL-2000 . ? ? ? ? 'data scaling' ? ? ? # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 ILE A 35 ? ? -160.70 112.98 2 1 HIS A 54 ? ? -87.21 -80.97 3 1 LYS A 56 ? ? -76.20 34.14 4 1 HIS A 127 ? ? 175.42 139.89 5 1 ILE A 133 ? ? -37.87 114.45 6 1 ALA A 135 ? ? -62.88 -71.64 7 1 ASP A 138 ? ? -50.31 109.11 8 1 GLU A 163 ? ? -46.55 -18.76 9 1 THR A 174 ? ? -101.30 -150.75 10 1 ASN A 192 ? ? -96.04 57.31 11 1 SER A 225 ? ? -47.20 156.18 12 1 CYS A 232 ? ? -175.57 -177.64 13 1 SER A 246 ? ? -86.04 38.75 14 1 LEU A 249 ? ? -49.20 -9.22 15 1 TRP A 285 ? ? -98.07 -68.74 16 1 TYR A 322 ? ? -103.42 -74.85 17 1 ASN A 323 ? ? -63.55 85.59 18 1 LYS A 327 ? ? -71.00 40.08 19 1 ARG A 328 ? ? -85.59 41.50 20 1 ILE A 329 ? ? -59.05 -1.87 21 1 SER A 332 ? ? -57.23 -76.80 22 1 ASN A 333 ? ? -35.65 -37.45 23 1 ASN A 341 ? ? -145.01 18.28 24 1 GLU A 345 ? ? 56.20 -133.07 25 1 VAL A 376 ? ? -142.16 18.94 26 1 LYS A 380 ? ? -99.38 -74.76 # loop_ _pdbx_validate_chiral.id _pdbx_validate_chiral.PDB_model_num _pdbx_validate_chiral.auth_atom_id _pdbx_validate_chiral.label_alt_id _pdbx_validate_chiral.auth_asym_id _pdbx_validate_chiral.auth_comp_id _pdbx_validate_chiral.auth_seq_id _pdbx_validate_chiral.PDB_ins_code _pdbx_validate_chiral.details _pdbx_validate_chiral.omega 1 1 C1 ? A NAG 501 ? 'WRONG HAND' . 2 1 C1 ? A NAG 502 ? 'WRONG HAND' . # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 Y 1 A VAL 42 ? CG1 ? A VAL 11 CG1 2 1 Y 1 A VAL 42 ? CG2 ? A VAL 11 CG2 3 1 Y 1 A THR 44 ? OG1 ? A THR 13 OG1 4 1 Y 1 A THR 44 ? CG2 ? A THR 13 CG2 5 1 Y 1 A GLU 55 ? CG ? A GLU 24 CG 6 1 Y 1 A GLU 55 ? CD ? A GLU 24 CD 7 1 Y 1 A GLU 55 ? OE1 ? A GLU 24 OE1 8 1 Y 1 A GLU 55 ? OE2 ? A GLU 24 OE2 9 1 Y 1 A LYS 56 ? CG ? A LYS 25 CG 10 1 Y 1 A LYS 56 ? CD ? A LYS 25 CD 11 1 Y 1 A LYS 56 ? CE ? A LYS 25 CE 12 1 Y 1 A LYS 56 ? NZ ? A LYS 25 NZ 13 1 Y 1 A SER 63 ? OG ? A SER 32 OG 14 1 Y 1 A ARG 67 ? CG ? A ARG 36 CG 15 1 Y 1 A ARG 67 ? CD ? A ARG 36 CD 16 1 Y 1 A ARG 67 ? NE ? A ARG 36 NE 17 1 Y 1 A ARG 67 ? CZ ? A ARG 36 CZ 18 1 Y 1 A ARG 67 ? NH1 ? A ARG 36 NH1 19 1 Y 1 A ARG 67 ? NH2 ? A ARG 36 NH2 20 1 Y 1 A GLU 69 ? CG ? A GLU 38 CG 21 1 Y 1 A GLU 69 ? CD ? A GLU 38 CD 22 1 Y 1 A GLU 69 ? OE1 ? A GLU 38 OE1 23 1 Y 1 A GLU 69 ? OE2 ? A GLU 38 OE2 24 1 Y 1 A MET 73 ? CG ? A MET 42 CG 25 1 Y 1 A MET 73 ? SD ? A MET 42 SD 26 1 Y 1 A MET 73 ? CE ? A MET 42 CE 27 1 Y 1 A GLU 75 ? CG ? A GLU 44 CG 28 1 Y 1 A GLU 75 ? CD ? A GLU 44 CD 29 1 Y 1 A GLU 75 ? OE1 ? A GLU 44 OE1 30 1 Y 1 A GLU 75 ? OE2 ? A GLU 44 OE2 31 1 Y 1 A LYS 79 ? CG ? A LYS 48 CG 32 1 Y 1 A LYS 79 ? CD ? A LYS 48 CD 33 1 Y 1 A LYS 79 ? CE ? A LYS 48 CE 34 1 Y 1 A LYS 79 ? NZ ? A LYS 48 NZ 35 1 Y 1 A ARG 92 ? CG ? A ARG 61 CG 36 1 Y 1 A ARG 92 ? CD ? A ARG 61 CD 37 1 Y 1 A ARG 92 ? NE ? A ARG 61 NE 38 1 Y 1 A ARG 92 ? CZ ? A ARG 61 CZ 39 1 Y 1 A ARG 92 ? NH1 ? A ARG 61 NH1 40 1 Y 1 A ARG 92 ? NH2 ? A ARG 61 NH2 41 1 Y 1 A LYS 93 ? CG ? A LYS 62 CG 42 1 Y 1 A LYS 93 ? CD ? A LYS 62 CD 43 1 Y 1 A LYS 93 ? CE ? A LYS 62 CE 44 1 Y 1 A LYS 93 ? NZ ? A LYS 62 NZ 45 1 Y 1 A ASP 102 ? CG ? A ASP 71 CG 46 1 Y 1 A ASP 102 ? OD1 ? A ASP 71 OD1 47 1 Y 1 A ASP 102 ? OD2 ? A ASP 71 OD2 48 1 Y 1 A ILE 111 ? CG1 ? A ILE 80 CG1 49 1 Y 1 A ILE 111 ? CG2 ? A ILE 80 CG2 50 1 Y 1 A ILE 111 ? CD1 ? A ILE 80 CD1 51 1 Y 1 A GLU 139 ? CG ? A GLU 108 CG 52 1 Y 1 A GLU 139 ? CD ? A GLU 108 CD 53 1 Y 1 A GLU 139 ? OE1 ? A GLU 108 OE1 54 1 Y 1 A GLU 139 ? OE2 ? A GLU 108 OE2 55 1 Y 1 A ILE 150 ? CG1 ? A ILE 119 CG1 56 1 Y 1 A ILE 150 ? CG2 ? A ILE 119 CG2 57 1 Y 1 A ILE 150 ? CD1 ? A ILE 119 CD1 58 1 Y 1 A GLU 151 ? CG ? A GLU 120 CG 59 1 Y 1 A GLU 151 ? CD ? A GLU 120 CD 60 1 Y 1 A GLU 151 ? OE1 ? A GLU 120 OE1 61 1 Y 1 A GLU 151 ? OE2 ? A GLU 120 OE2 62 1 Y 1 A GLN 152 ? CG ? A GLN 121 CG 63 1 Y 1 A GLN 152 ? CD ? A GLN 121 CD 64 1 Y 1 A GLN 152 ? OE1 ? A GLN 121 OE1 65 1 Y 1 A GLN 152 ? NE2 ? A GLN 121 NE2 66 1 Y 1 A SER 155 ? OG ? A SER 124 OG 67 1 Y 1 A ILE 168 ? CG1 ? A ILE 137 CG1 68 1 Y 1 A ILE 168 ? CG2 ? A ILE 137 CG2 69 1 Y 1 A ILE 168 ? CD1 ? A ILE 137 CD1 70 1 Y 1 A GLN 180 ? CG ? A GLN 149 CG 71 1 Y 1 A GLN 180 ? CD ? A GLN 149 CD 72 1 Y 1 A GLN 180 ? OE1 ? A GLN 149 OE1 73 1 Y 1 A GLN 180 ? NE2 ? A GLN 149 NE2 74 1 Y 1 A ASP 181 ? CG ? A ASP 150 CG 75 1 Y 1 A ASP 181 ? OD1 ? A ASP 150 OD1 76 1 Y 1 A ASP 181 ? OD2 ? A ASP 150 OD2 77 1 Y 1 A GLU 191 ? CG ? A GLU 160 CG 78 1 Y 1 A GLU 191 ? CD ? A GLU 160 CD 79 1 Y 1 A GLU 191 ? OE1 ? A GLU 160 OE1 80 1 Y 1 A GLU 191 ? OE2 ? A GLU 160 OE2 81 1 Y 1 A SER 193 ? OG ? A SER 162 OG 82 1 Y 1 A PHE 194 ? CG ? A PHE 163 CG 83 1 Y 1 A PHE 194 ? CD1 ? A PHE 163 CD1 84 1 Y 1 A PHE 194 ? CD2 ? A PHE 163 CD2 85 1 Y 1 A PHE 194 ? CE1 ? A PHE 163 CE1 86 1 Y 1 A PHE 194 ? CE2 ? A PHE 163 CE2 87 1 Y 1 A PHE 194 ? CZ ? A PHE 163 CZ 88 1 Y 1 A GLU 198 ? CG ? A GLU 167 CG 89 1 Y 1 A GLU 198 ? CD ? A GLU 167 CD 90 1 Y 1 A GLU 198 ? OE1 ? A GLU 167 OE1 91 1 Y 1 A GLU 198 ? OE2 ? A GLU 167 OE2 92 1 Y 1 A SER 214 ? OG ? A SER 183 OG 93 1 Y 1 A LYS 215 ? CG ? A LYS 184 CG 94 1 Y 1 A LYS 215 ? CD ? A LYS 184 CD 95 1 Y 1 A LYS 215 ? CE ? A LYS 184 CE 96 1 Y 1 A LYS 215 ? NZ ? A LYS 184 NZ 97 1 Y 1 A ILE 216 ? CG1 ? A ILE 185 CG1 98 1 Y 1 A ILE 216 ? CG2 ? A ILE 185 CG2 99 1 Y 1 A ILE 216 ? CD1 ? A ILE 185 CD1 100 1 Y 1 A GLN 217 ? CG ? A GLN 186 CG 101 1 Y 1 A GLN 217 ? CD ? A GLN 186 CD 102 1 Y 1 A GLN 217 ? OE1 ? A GLN 186 OE1 103 1 Y 1 A GLN 217 ? NE2 ? A GLN 186 NE2 104 1 Y 1 A ASN 218 ? CG ? A ASN 187 CG 105 1 Y 1 A ASN 218 ? OD1 ? A ASN 187 OD1 106 1 Y 1 A ASN 218 ? ND2 ? A ASN 187 ND2 107 1 Y 1 A LEU 220 ? CG ? A LEU 189 CG 108 1 Y 1 A LEU 220 ? CD1 ? A LEU 189 CD1 109 1 Y 1 A LEU 220 ? CD2 ? A LEU 189 CD2 110 1 Y 1 A LYS 221 ? CG ? A LYS 190 CG 111 1 Y 1 A LYS 221 ? CD ? A LYS 190 CD 112 1 Y 1 A LYS 221 ? CE ? A LYS 190 CE 113 1 Y 1 A LYS 221 ? NZ ? A LYS 190 NZ 114 1 Y 1 A LYS 222 ? CG ? A LYS 191 CG 115 1 Y 1 A LYS 222 ? CD ? A LYS 191 CD 116 1 Y 1 A LYS 222 ? CE ? A LYS 191 CE 117 1 Y 1 A LYS 222 ? NZ ? A LYS 191 NZ 118 1 Y 1 A GLN 224 ? CG ? A GLN 193 CG 119 1 Y 1 A GLN 224 ? CD ? A GLN 193 CD 120 1 Y 1 A GLN 224 ? OE1 ? A GLN 193 OE1 121 1 Y 1 A GLN 224 ? NE2 ? A GLN 193 NE2 122 1 Y 1 A GLU 235 ? CG ? A GLU 204 CG 123 1 Y 1 A GLU 235 ? CD ? A GLU 204 CD 124 1 Y 1 A GLU 235 ? OE1 ? A GLU 204 OE1 125 1 Y 1 A GLU 235 ? OE2 ? A GLU 204 OE2 126 1 Y 1 A TYR 239 ? CG ? A TYR 208 CG 127 1 Y 1 A TYR 239 ? CD1 ? A TYR 208 CD1 128 1 Y 1 A TYR 239 ? CD2 ? A TYR 208 CD2 129 1 Y 1 A TYR 239 ? CE1 ? A TYR 208 CE1 130 1 Y 1 A TYR 239 ? CE2 ? A TYR 208 CE2 131 1 Y 1 A TYR 239 ? CZ ? A TYR 208 CZ 132 1 Y 1 A TYR 239 ? OH ? A TYR 208 OH 133 1 Y 1 A GLU 242 ? CG ? A GLU 211 CG 134 1 Y 1 A GLU 242 ? CD ? A GLU 211 CD 135 1 Y 1 A GLU 242 ? OE1 ? A GLU 211 OE1 136 1 Y 1 A GLU 242 ? OE2 ? A GLU 211 OE2 137 1 Y 1 A LEU 249 ? CG ? A LEU 218 CG 138 1 Y 1 A LEU 249 ? CD1 ? A LEU 218 CD1 139 1 Y 1 A LEU 249 ? CD2 ? A LEU 218 CD2 140 1 Y 1 A THR 250 ? OG1 ? A THR 219 OG1 141 1 Y 1 A THR 250 ? CG2 ? A THR 219 CG2 142 1 Y 1 A SER 281 ? OG ? A SER 250 OG 143 1 Y 1 A TRP 285 ? CG ? A TRP 254 CG 144 1 Y 1 A TRP 285 ? CD1 ? A TRP 254 CD1 145 1 Y 1 A TRP 285 ? CD2 ? A TRP 254 CD2 146 1 Y 1 A TRP 285 ? NE1 ? A TRP 254 NE1 147 1 Y 1 A TRP 285 ? CE2 ? A TRP 254 CE2 148 1 Y 1 A TRP 285 ? CE3 ? A TRP 254 CE3 149 1 Y 1 A TRP 285 ? CZ2 ? A TRP 254 CZ2 150 1 Y 1 A TRP 285 ? CZ3 ? A TRP 254 CZ3 151 1 Y 1 A TRP 285 ? CH2 ? A TRP 254 CH2 152 1 Y 1 A ASP 286 ? CG ? A ASP 255 CG 153 1 Y 1 A ASP 286 ? OD1 ? A ASP 255 OD1 154 1 Y 1 A ASP 286 ? OD2 ? A ASP 255 OD2 155 1 Y 1 A LEU 308 ? CG ? A LEU 277 CG 156 1 Y 1 A LEU 308 ? CD1 ? A LEU 277 CD1 157 1 Y 1 A LEU 308 ? CD2 ? A LEU 277 CD2 158 1 Y 1 A SER 309 ? OG ? A SER 278 OG 159 1 Y 1 A GLU 310 ? CG ? A GLU 279 CG 160 1 Y 1 A GLU 310 ? CD ? A GLU 279 CD 161 1 Y 1 A GLU 310 ? OE1 ? A GLU 279 OE1 162 1 Y 1 A GLU 310 ? OE2 ? A GLU 279 OE2 163 1 Y 1 A SER 312 ? OG ? A SER 281 OG 164 1 Y 1 A PHE 313 ? CG ? A PHE 282 CG 165 1 Y 1 A PHE 313 ? CD1 ? A PHE 282 CD1 166 1 Y 1 A PHE 313 ? CD2 ? A PHE 282 CD2 167 1 Y 1 A PHE 313 ? CE1 ? A PHE 282 CE1 168 1 Y 1 A PHE 313 ? CE2 ? A PHE 282 CE2 169 1 Y 1 A PHE 313 ? CZ ? A PHE 282 CZ 170 1 Y 1 A GLU 316 ? CG ? A GLU 285 CG 171 1 Y 1 A GLU 316 ? CD ? A GLU 285 CD 172 1 Y 1 A GLU 316 ? OE1 ? A GLU 285 OE1 173 1 Y 1 A GLU 316 ? OE2 ? A GLU 285 OE2 174 1 Y 1 A HIS 325 ? CG ? A HIS 294 CG 175 1 Y 1 A HIS 325 ? ND1 ? A HIS 294 ND1 176 1 Y 1 A HIS 325 ? CD2 ? A HIS 294 CD2 177 1 Y 1 A HIS 325 ? CE1 ? A HIS 294 CE1 178 1 Y 1 A HIS 325 ? NE2 ? A HIS 294 NE2 179 1 Y 1 A GLU 326 ? CG ? A GLU 295 CG 180 1 Y 1 A GLU 326 ? CD ? A GLU 295 CD 181 1 Y 1 A GLU 326 ? OE1 ? A GLU 295 OE1 182 1 Y 1 A GLU 326 ? OE2 ? A GLU 295 OE2 183 1 Y 1 A LYS 327 ? CG ? A LYS 296 CG 184 1 Y 1 A LYS 327 ? CD ? A LYS 296 CD 185 1 Y 1 A LYS 327 ? CE ? A LYS 296 CE 186 1 Y 1 A LYS 327 ? NZ ? A LYS 296 NZ 187 1 Y 1 A ARG 328 ? CG ? A ARG 297 CG 188 1 Y 1 A ARG 328 ? CD ? A ARG 297 CD 189 1 Y 1 A ARG 328 ? NE ? A ARG 297 NE 190 1 Y 1 A ARG 328 ? CZ ? A ARG 297 CZ 191 1 Y 1 A ARG 328 ? NH1 ? A ARG 297 NH1 192 1 Y 1 A ARG 328 ? NH2 ? A ARG 297 NH2 193 1 Y 1 A ILE 329 ? CG1 ? A ILE 298 CG1 194 1 Y 1 A ILE 329 ? CG2 ? A ILE 298 CG2 195 1 Y 1 A ILE 329 ? CD1 ? A ILE 298 CD1 196 1 Y 1 A MET 334 ? CG ? A MET 303 CG 197 1 Y 1 A MET 334 ? SD ? A MET 303 SD 198 1 Y 1 A MET 334 ? CE ? A MET 303 CE 199 1 Y 1 A ARG 337 ? CG ? A ARG 306 CG 200 1 Y 1 A ARG 337 ? CD ? A ARG 306 CD 201 1 Y 1 A ARG 337 ? NE ? A ARG 306 NE 202 1 Y 1 A ARG 337 ? CZ ? A ARG 306 CZ 203 1 Y 1 A ARG 337 ? NH1 ? A ARG 306 NH1 204 1 Y 1 A ARG 337 ? NH2 ? A ARG 306 NH2 205 1 Y 1 A ARG 347 ? CG ? A ARG 316 CG 206 1 Y 1 A ARG 347 ? CD ? A ARG 316 CD 207 1 Y 1 A ARG 347 ? NE ? A ARG 316 NE 208 1 Y 1 A ARG 347 ? CZ ? A ARG 316 CZ 209 1 Y 1 A ARG 347 ? NH1 ? A ARG 316 NH1 210 1 Y 1 A ARG 347 ? NH2 ? A ARG 316 NH2 211 1 Y 1 A GLU 353 ? CG ? A GLU 322 CG 212 1 Y 1 A GLU 353 ? CD ? A GLU 322 CD 213 1 Y 1 A GLU 353 ? OE1 ? A GLU 322 OE1 214 1 Y 1 A GLU 353 ? OE2 ? A GLU 322 OE2 215 1 Y 1 A LYS 361 ? CG ? A LYS 330 CG 216 1 Y 1 A LYS 361 ? CD ? A LYS 330 CD 217 1 Y 1 A LYS 361 ? CE ? A LYS 330 CE 218 1 Y 1 A LYS 361 ? NZ ? A LYS 330 NZ 219 1 Y 1 A LYS 369 ? CG ? A LYS 338 CG 220 1 Y 1 A LYS 369 ? CD ? A LYS 338 CD 221 1 Y 1 A LYS 369 ? CE ? A LYS 338 CE 222 1 Y 1 A LYS 369 ? NZ ? A LYS 338 NZ 223 1 Y 1 A GLU 370 ? CG ? A GLU 339 CG 224 1 Y 1 A GLU 370 ? CD ? A GLU 339 CD 225 1 Y 1 A GLU 370 ? OE1 ? A GLU 339 OE1 226 1 Y 1 A GLU 370 ? OE2 ? A GLU 339 OE2 227 1 Y 1 A LYS 372 ? CG ? A LYS 341 CG 228 1 Y 1 A LYS 372 ? CD ? A LYS 341 CD 229 1 Y 1 A LYS 372 ? CE ? A LYS 341 CE 230 1 Y 1 A LYS 372 ? NZ ? A LYS 341 NZ 231 1 Y 1 A ARG 375 ? CG ? A ARG 344 CG 232 1 Y 1 A ARG 375 ? CD ? A ARG 344 CD 233 1 Y 1 A ARG 375 ? NE ? A ARG 344 NE 234 1 Y 1 A ARG 375 ? CZ ? A ARG 344 CZ 235 1 Y 1 A ARG 375 ? NH1 ? A ARG 344 NH1 236 1 Y 1 A ARG 375 ? NH2 ? A ARG 344 NH2 237 1 Y 1 A LYS 378 ? CG ? A LYS 347 CG 238 1 Y 1 A LYS 378 ? CD ? A LYS 347 CD 239 1 Y 1 A LYS 378 ? CE ? A LYS 347 CE 240 1 Y 1 A LYS 378 ? NZ ? A LYS 347 NZ 241 1 Y 1 A LYS 380 ? CG ? A LYS 349 CG 242 1 Y 1 A LYS 380 ? CD ? A LYS 349 CD 243 1 Y 1 A LYS 380 ? CE ? A LYS 349 CE 244 1 Y 1 A LYS 380 ? NZ ? A LYS 349 NZ 245 1 Y 1 A LYS 382 ? CG ? A LYS 351 CG 246 1 Y 1 A LYS 382 ? CD ? A LYS 351 CD 247 1 Y 1 A LYS 382 ? CE ? A LYS 351 CE 248 1 Y 1 A LYS 382 ? NZ ? A LYS 351 NZ 249 1 Y 1 A SER 383 ? OG ? A SER 352 OG 250 1 Y 1 A LYS 387 ? CG ? A LYS 356 CG 251 1 Y 1 A LYS 387 ? CD ? A LYS 356 CD 252 1 Y 1 A LYS 387 ? CE ? A LYS 356 CE 253 1 Y 1 A LYS 387 ? NZ ? A LYS 356 NZ 254 1 Y 1 A ARG 393 ? CG ? A ARG 362 CG 255 1 Y 1 A ARG 393 ? CD ? A ARG 362 CD 256 1 Y 1 A ARG 393 ? NE ? A ARG 362 NE 257 1 Y 1 A ARG 393 ? CZ ? A ARG 362 CZ 258 1 Y 1 A ARG 393 ? NH1 ? A ARG 362 NH1 259 1 Y 1 A ARG 393 ? NH2 ? A ARG 362 NH2 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A LEU 209 ? A LEU 178 2 1 Y 1 A ASP 210 ? A ASP 179 3 1 Y 1 A ASP 211 ? A ASP 180 4 1 Y 1 A GLY 212 ? A GLY 181 5 1 Y 1 A ASP 213 ? A ASP 182 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 'CHLORIDE ION' CL 4 'SODIUM ION' NA 5 'ZINC ION' ZN 6 water HOH #