data_2WIG # _entry.id 2WIG # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.287 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 2WIG WWPDB D_1290039779 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.content_type _pdbx_database_related.details PDB 1EHQ unspecified 'MODEL OF (+)-COCAINE-BOUND BCHE COMPLEX' PDB 1P0Q unspecified 'CRYSTAL STRUCTURE OF SOMAN-AGED HUMAN BUTYRYL CHOLINESTERASE' PDB 2J4C unspecified 'STRUCTURE OF HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH 10MM HGCL2' PDB 1KCJ unspecified 'MODEL OF (-)-COCAINE-BOUND (-)-COCAINE HYDROLASE COMPLEX' PDB 1P0P unspecified 'CRYSTAL STRUCTURE OF SOMAN-AGED HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH THE SUBSTRATE ANALOGBUTYRYLTHIOCHOLINE' PDB 1XLU unspecified 'X-RAY STRUCTURE OF DI-ISOPROPYL-PHOSPHORO- FLUORIDATE (DFP)INHIBITED BUTYRYLCHOLINESTERASE AFTER AGING' PDB 1XLV unspecified 'ETHYLPHOSPHORYLATED BUTYRYLCHOLINESTERASE (AGED) OBTAINEDBY REACTION WITH ECHOTHIOPHATE' PDB 1EHO unspecified 'MODEL OF (-)-COCAINE-BOUND BCHE COMPLEX.' PDB 1P0M unspecified 'CRYSTAL STRUCTURE OF HUMAN BUTYRYL CHOLINESTERASE INCOMPLEX WITH A CHOLINE MOLECULE' PDB 1XLW unspecified 'DIETHYLPHOSPHORYLATED BUTYRYLCHOLINESTERASE (NONAGED) OBTAINED BY REACTION WITH ECHOTHIOPHATE' PDB 1P0I unspecified 'CRYSTAL STRUCTURE OF HUMAN BUTYRYL CHOLINESTERASE' PDB 2WIK unspecified 'NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA6' PDB 2WIF unspecified 'NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA1' PDB 2WID unspecified 'AGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA1' PDB 2WIJ unspecified 'NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA5' # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 2WIG _pdbx_database_status.recvd_initial_deposition_date 2009-05-11 _pdbx_database_status.deposit_site PDBE _pdbx_database_status.process_site PDBE _pdbx_database_status.SG_entry ? _pdbx_database_status.pdb_format_compatible Y _pdbx_database_status.status_code_sf ? _pdbx_database_status.status_code_mr ? _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? # loop_ _audit_author.name _audit_author.pdbx_ordinal _audit_author.identifier_ORCID 'Carletti, E.' 1 ? 'Aurbek, N.' 2 ? 'Gillon, E.' 3 ? 'Loiodice, M.' 4 ? 'Nicolet, Y.' 5 ? 'Fontecilla, J.' 6 ? 'Masson, P.' 7 ? 'Thiermann, H.' 8 ? 'Nachon, F.' 9 ? 'Worek, F.' 10 ? # _citation.id primary _citation.title 'Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun.' _citation.journal_abbrev 'Biochem. J.' _citation.journal_volume 421 _citation.page_first 97 _citation.page_last 106 _citation.year 2009 _citation.journal_id_ASTM BIJOAK _citation.country UK _citation.journal_id_ISSN 1470-8728 _citation.journal_id_CSD 0043 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 19368529 _citation.pdbx_database_id_DOI 10.1042/BJ20090091 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Carletti, E.' 1 primary 'Aurbek, N.' 2 primary 'Gillon, E.' 3 primary 'Loiodice, M.' 4 primary 'Nicolet, Y.' 5 primary 'Fontecilla-Camps, J.C.' 6 primary 'Masson, P.' 7 primary 'Thiermann, H.' 8 primary 'Nachon, F.' 9 primary 'Worek, F.' 10 # _cell.entry_id 2WIG _cell.length_a 155.010 _cell.length_b 155.010 _cell.length_c 126.840 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 90.00 _cell.Z_PDB 16 _cell.pdbx_unique_axis ? # _symmetry.entry_id 2WIG _symmetry.space_group_name_H-M 'I 4 2 2' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 97 # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man CHOLINESTERASE 59713.512 1 3.1.1.8 YES 'RESIDUES 29-557' 'S198 IS PHOSPHORAMIDYLATED' 2 non-polymer syn 'ETHYL HYDROGEN METHYLAMIDOPHOSPHATE' 139.090 1 ? ? ? ? 3 non-polymer syn 'SODIUM ION' 22.990 1 ? ? ? ? 4 non-polymer syn 'SULFATE ION' 96.063 2 ? ? ? ? 5 non-polymer syn 'CHLORIDE ION' 35.453 4 ? ? ? ? 6 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 8 ? ? ? ? 7 non-polymer man BETA-L-FUCOSE 164.156 3 ? ? ? ? 8 water nat water 18.015 343 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name 'BUTYRYLCHOLINESTERASE, ACYLCHOLINE ACYLHYDROLASE, CHOLINE ESTERASE II, BUTYRYLCHOLINE ESTERASE, PSEUDOCHOLINESTERASE' # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;EDDIIIATKNGKVRGMQLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWTDIWNATKYANSCCQNIDQSFPGFHGSE MWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNP EAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEAR NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVG VNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFIC PALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDQYTKAEEILSRSIVKRWANFAKYGNP QETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKV ; _entity_poly.pdbx_seq_one_letter_code_can ;EDDIIIATKNGKVRGMQLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWTDIWNATKYANSCCQNIDQSFPGFHGSE MWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNP EAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEAR NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVG VNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFIC PALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDQYTKAEEILSRSIVKRWANFAKYGNP QETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKV ; _entity_poly.pdbx_strand_id A _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 GLU n 1 2 ASP n 1 3 ASP n 1 4 ILE n 1 5 ILE n 1 6 ILE n 1 7 ALA n 1 8 THR n 1 9 LYS n 1 10 ASN n 1 11 GLY n 1 12 LYS n 1 13 VAL n 1 14 ARG n 1 15 GLY n 1 16 MET n 1 17 GLN n 1 18 LEU n 1 19 THR n 1 20 VAL n 1 21 PHE n 1 22 GLY n 1 23 GLY n 1 24 THR n 1 25 VAL n 1 26 THR n 1 27 ALA n 1 28 PHE n 1 29 LEU n 1 30 GLY n 1 31 ILE n 1 32 PRO n 1 33 TYR n 1 34 ALA n 1 35 GLN n 1 36 PRO n 1 37 PRO n 1 38 LEU n 1 39 GLY n 1 40 ARG n 1 41 LEU n 1 42 ARG n 1 43 PHE n 1 44 LYS n 1 45 LYS n 1 46 PRO n 1 47 GLN n 1 48 SER n 1 49 LEU n 1 50 THR n 1 51 LYS n 1 52 TRP n 1 53 THR n 1 54 ASP n 1 55 ILE n 1 56 TRP n 1 57 ASN n 1 58 ALA n 1 59 THR n 1 60 LYS n 1 61 TYR n 1 62 ALA n 1 63 ASN n 1 64 SER n 1 65 CYS n 1 66 CYS n 1 67 GLN n 1 68 ASN n 1 69 ILE n 1 70 ASP n 1 71 GLN n 1 72 SER n 1 73 PHE n 1 74 PRO n 1 75 GLY n 1 76 PHE n 1 77 HIS n 1 78 GLY n 1 79 SER n 1 80 GLU n 1 81 MET n 1 82 TRP n 1 83 ASN n 1 84 PRO n 1 85 ASN n 1 86 THR n 1 87 ASP n 1 88 LEU n 1 89 SER n 1 90 GLU n 1 91 ASP n 1 92 CYS n 1 93 LEU n 1 94 TYR n 1 95 LEU n 1 96 ASN n 1 97 VAL n 1 98 TRP n 1 99 ILE n 1 100 PRO n 1 101 ALA n 1 102 PRO n 1 103 LYS n 1 104 PRO n 1 105 LYS n 1 106 ASN n 1 107 ALA n 1 108 THR n 1 109 VAL n 1 110 LEU n 1 111 ILE n 1 112 TRP n 1 113 ILE n 1 114 TYR n 1 115 GLY n 1 116 GLY n 1 117 GLY n 1 118 PHE n 1 119 GLN n 1 120 THR n 1 121 GLY n 1 122 THR n 1 123 SER n 1 124 SER n 1 125 LEU n 1 126 HIS n 1 127 VAL n 1 128 TYR n 1 129 ASP n 1 130 GLY n 1 131 LYS n 1 132 PHE n 1 133 LEU n 1 134 ALA n 1 135 ARG n 1 136 VAL n 1 137 GLU n 1 138 ARG n 1 139 VAL n 1 140 ILE n 1 141 VAL n 1 142 VAL n 1 143 SER n 1 144 MET n 1 145 ASN n 1 146 TYR n 1 147 ARG n 1 148 VAL n 1 149 GLY n 1 150 ALA n 1 151 LEU n 1 152 GLY n 1 153 PHE n 1 154 LEU n 1 155 ALA n 1 156 LEU n 1 157 PRO n 1 158 GLY n 1 159 ASN n 1 160 PRO n 1 161 GLU n 1 162 ALA n 1 163 PRO n 1 164 GLY n 1 165 ASN n 1 166 MET n 1 167 GLY n 1 168 LEU n 1 169 PHE n 1 170 ASP n 1 171 GLN n 1 172 GLN n 1 173 LEU n 1 174 ALA n 1 175 LEU n 1 176 GLN n 1 177 TRP n 1 178 VAL n 1 179 GLN n 1 180 LYS n 1 181 ASN n 1 182 ILE n 1 183 ALA n 1 184 ALA n 1 185 PHE n 1 186 GLY n 1 187 GLY n 1 188 ASN n 1 189 PRO n 1 190 LYS n 1 191 SER n 1 192 VAL n 1 193 THR n 1 194 LEU n 1 195 PHE n 1 196 GLY n 1 197 GLU n 1 198 SER n 1 199 ALA n 1 200 GLY n 1 201 ALA n 1 202 ALA n 1 203 SER n 1 204 VAL n 1 205 SER n 1 206 LEU n 1 207 HIS n 1 208 LEU n 1 209 LEU n 1 210 SER n 1 211 PRO n 1 212 GLY n 1 213 SER n 1 214 HIS n 1 215 SER n 1 216 LEU n 1 217 PHE n 1 218 THR n 1 219 ARG n 1 220 ALA n 1 221 ILE n 1 222 LEU n 1 223 GLN n 1 224 SER n 1 225 GLY n 1 226 SER n 1 227 PHE n 1 228 ASN n 1 229 ALA n 1 230 PRO n 1 231 TRP n 1 232 ALA n 1 233 VAL n 1 234 THR n 1 235 SER n 1 236 LEU n 1 237 TYR n 1 238 GLU n 1 239 ALA n 1 240 ARG n 1 241 ASN n 1 242 ARG n 1 243 THR n 1 244 LEU n 1 245 ASN n 1 246 LEU n 1 247 ALA n 1 248 LYS n 1 249 LEU n 1 250 THR n 1 251 GLY n 1 252 CYS n 1 253 SER n 1 254 ARG n 1 255 GLU n 1 256 ASN n 1 257 GLU n 1 258 THR n 1 259 GLU n 1 260 ILE n 1 261 ILE n 1 262 LYS n 1 263 CYS n 1 264 LEU n 1 265 ARG n 1 266 ASN n 1 267 LYS n 1 268 ASP n 1 269 PRO n 1 270 GLN n 1 271 GLU n 1 272 ILE n 1 273 LEU n 1 274 LEU n 1 275 ASN n 1 276 GLU n 1 277 ALA n 1 278 PHE n 1 279 VAL n 1 280 VAL n 1 281 PRO n 1 282 TYR n 1 283 GLY n 1 284 THR n 1 285 PRO n 1 286 LEU n 1 287 SER n 1 288 VAL n 1 289 ASN n 1 290 PHE n 1 291 GLY n 1 292 PRO n 1 293 THR n 1 294 VAL n 1 295 ASP n 1 296 GLY n 1 297 ASP n 1 298 PHE n 1 299 LEU n 1 300 THR n 1 301 ASP n 1 302 MET n 1 303 PRO n 1 304 ASP n 1 305 ILE n 1 306 LEU n 1 307 LEU n 1 308 GLU n 1 309 LEU n 1 310 GLY n 1 311 GLN n 1 312 PHE n 1 313 LYS n 1 314 LYS n 1 315 THR n 1 316 GLN n 1 317 ILE n 1 318 LEU n 1 319 VAL n 1 320 GLY n 1 321 VAL n 1 322 ASN n 1 323 LYS n 1 324 ASP n 1 325 GLU n 1 326 GLY n 1 327 THR n 1 328 ALA n 1 329 PHE n 1 330 LEU n 1 331 VAL n 1 332 TYR n 1 333 GLY n 1 334 ALA n 1 335 PRO n 1 336 GLY n 1 337 PHE n 1 338 SER n 1 339 LYS n 1 340 ASP n 1 341 ASN n 1 342 ASN n 1 343 SER n 1 344 ILE n 1 345 ILE n 1 346 THR n 1 347 ARG n 1 348 LYS n 1 349 GLU n 1 350 PHE n 1 351 GLN n 1 352 GLU n 1 353 GLY n 1 354 LEU n 1 355 LYS n 1 356 ILE n 1 357 PHE n 1 358 PHE n 1 359 PRO n 1 360 GLY n 1 361 VAL n 1 362 SER n 1 363 GLU n 1 364 PHE n 1 365 GLY n 1 366 LYS n 1 367 GLU n 1 368 SER n 1 369 ILE n 1 370 LEU n 1 371 PHE n 1 372 HIS n 1 373 TYR n 1 374 THR n 1 375 ASP n 1 376 TRP n 1 377 VAL n 1 378 ASP n 1 379 ASP n 1 380 GLN n 1 381 ARG n 1 382 PRO n 1 383 GLU n 1 384 ASN n 1 385 TYR n 1 386 ARG n 1 387 GLU n 1 388 ALA n 1 389 LEU n 1 390 GLY n 1 391 ASP n 1 392 VAL n 1 393 VAL n 1 394 GLY n 1 395 ASP n 1 396 TYR n 1 397 ASN n 1 398 PHE n 1 399 ILE n 1 400 CYS n 1 401 PRO n 1 402 ALA n 1 403 LEU n 1 404 GLU n 1 405 PHE n 1 406 THR n 1 407 LYS n 1 408 LYS n 1 409 PHE n 1 410 SER n 1 411 GLU n 1 412 TRP n 1 413 GLY n 1 414 ASN n 1 415 ASN n 1 416 ALA n 1 417 PHE n 1 418 PHE n 1 419 TYR n 1 420 TYR n 1 421 PHE n 1 422 GLU n 1 423 HIS n 1 424 ARG n 1 425 SER n 1 426 SER n 1 427 LYS n 1 428 LEU n 1 429 PRO n 1 430 TRP n 1 431 PRO n 1 432 GLU n 1 433 TRP n 1 434 MET n 1 435 GLY n 1 436 VAL n 1 437 MET n 1 438 HIS n 1 439 GLY n 1 440 TYR n 1 441 GLU n 1 442 ILE n 1 443 GLU n 1 444 PHE n 1 445 VAL n 1 446 PHE n 1 447 GLY n 1 448 LEU n 1 449 PRO n 1 450 LEU n 1 451 GLU n 1 452 ARG n 1 453 ARG n 1 454 ASP n 1 455 GLN n 1 456 TYR n 1 457 THR n 1 458 LYS n 1 459 ALA n 1 460 GLU n 1 461 GLU n 1 462 ILE n 1 463 LEU n 1 464 SER n 1 465 ARG n 1 466 SER n 1 467 ILE n 1 468 VAL n 1 469 LYS n 1 470 ARG n 1 471 TRP n 1 472 ALA n 1 473 ASN n 1 474 PHE n 1 475 ALA n 1 476 LYS n 1 477 TYR n 1 478 GLY n 1 479 ASN n 1 480 PRO n 1 481 GLN n 1 482 GLU n 1 483 THR n 1 484 GLN n 1 485 ASN n 1 486 ASN n 1 487 SER n 1 488 THR n 1 489 SER n 1 490 TRP n 1 491 PRO n 1 492 VAL n 1 493 PHE n 1 494 LYS n 1 495 SER n 1 496 THR n 1 497 GLU n 1 498 GLN n 1 499 LYS n 1 500 TYR n 1 501 LEU n 1 502 THR n 1 503 LEU n 1 504 ASN n 1 505 THR n 1 506 GLU n 1 507 SER n 1 508 THR n 1 509 ARG n 1 510 ILE n 1 511 MET n 1 512 THR n 1 513 LYS n 1 514 LEU n 1 515 ARG n 1 516 ALA n 1 517 GLN n 1 518 GLN n 1 519 CYS n 1 520 ARG n 1 521 PHE n 1 522 TRP n 1 523 THR n 1 524 SER n 1 525 PHE n 1 526 PHE n 1 527 PRO n 1 528 LYS n 1 529 VAL n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name HUMAN _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene ? _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'HOMO SAPIENS' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 9606 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'CRICETULUS GRISEUS' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 10029 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain ? _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line CHO-K1 _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type PLASMID _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name PGS _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code CHLE_HUMAN _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ? _struct_ref.pdbx_align_begin ? _struct_ref.pdbx_db_accession P06276 _struct_ref.pdbx_db_isoform ? # _struct_ref_seq.align_id 1 _struct_ref_seq.ref_id 1 _struct_ref_seq.pdbx_PDB_id_code 2WIG _struct_ref_seq.pdbx_strand_id A _struct_ref_seq.seq_align_beg 1 _struct_ref_seq.pdbx_seq_align_beg_ins_code ? _struct_ref_seq.seq_align_end 529 _struct_ref_seq.pdbx_seq_align_end_ins_code ? _struct_ref_seq.pdbx_db_accession P06276 _struct_ref_seq.db_align_beg 29 _struct_ref_seq.pdbx_db_align_beg_ins_code ? _struct_ref_seq.db_align_end 557 _struct_ref_seq.pdbx_db_align_end_ins_code ? _struct_ref_seq.pdbx_auth_seq_align_beg 1 _struct_ref_seq.pdbx_auth_seq_align_end 529 # loop_ _struct_ref_seq_dif.align_id _struct_ref_seq_dif.pdbx_pdb_id_code _struct_ref_seq_dif.mon_id _struct_ref_seq_dif.pdbx_pdb_strand_id _struct_ref_seq_dif.seq_num _struct_ref_seq_dif.pdbx_pdb_ins_code _struct_ref_seq_dif.pdbx_seq_db_name _struct_ref_seq_dif.pdbx_seq_db_accession_code _struct_ref_seq_dif.db_mon_id _struct_ref_seq_dif.pdbx_seq_db_seq_num _struct_ref_seq_dif.details _struct_ref_seq_dif.pdbx_auth_seq_num _struct_ref_seq_dif.pdbx_ordinal 1 2WIG GLN A 17 ? UNP P06276 ASN 45 'engineered mutation' 17 1 1 2WIG THR A 53 ? UNP P06276 SER 81 conflict 53 2 1 2WIG GLN A 455 ? UNP P06276 ASN 483 'engineered mutation' 455 3 1 2WIG GLN A 481 ? UNP P06276 ASN 509 'engineered mutation' 481 4 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CL non-polymer . 'CHLORIDE ION' ? 'Cl -1' 35.453 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 FUL L-saccharide . BETA-L-FUCOSE 6-DEOXY-BETA-L-GALACTOSE 'C6 H12 O5' 164.156 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NA non-polymer . 'SODIUM ION' ? 'Na 1' 22.990 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 SO4 non-polymer . 'SULFATE ION' ? 'O4 S -2' 96.063 TC3 non-polymer . 'ETHYL HYDROGEN METHYLAMIDOPHOSPHATE' ? 'C3 H10 N O3 P' 139.090 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 2WIG _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 3.19 _exptl_crystal.density_percent_sol 61.5 _exptl_crystal.description NONE # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method ? _exptl_crystal_grow.temp ? _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 6.5 _exptl_crystal_grow.pdbx_pH_range ? _exptl_crystal_grow.pdbx_details '2.1 M AMMONIUM SULFATE, 100 MM MES PH 6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K' # _diffrn.id 1 _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type 'ADSC CCD' _diffrn_detector.pdbx_collection_date 2007-09-09 _diffrn_detector.details ? # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator ? _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.934 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'ESRF BEAMLINE ID14-4' _diffrn_source.pdbx_synchrotron_site ESRF _diffrn_source.pdbx_synchrotron_beamline ID14-4 _diffrn_source.pdbx_wavelength 0.934 _diffrn_source.pdbx_wavelength_list ? # _reflns.pdbx_diffrn_id 1 _reflns.pdbx_ordinal 1 _reflns.entry_id 2WIG _reflns.observed_criterion_sigma_I 2.0 _reflns.observed_criterion_sigma_F ? _reflns.d_resolution_low 49.00 _reflns.d_resolution_high 2.15 _reflns.number_obs 41918 _reflns.number_all ? _reflns.percent_possible_obs 99.7 _reflns.pdbx_Rmerge_I_obs 0.08 _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI 25.80 _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy 7.2 # _reflns_shell.pdbx_diffrn_id 1 _reflns_shell.pdbx_ordinal 1 _reflns_shell.d_res_high 2.15 _reflns_shell.d_res_low 2.20 _reflns_shell.percent_possible_all 99.7 _reflns_shell.Rmerge_I_obs 0.29 _reflns_shell.pdbx_Rsym_value ? _reflns_shell.meanI_over_sigI_obs 4.30 _reflns_shell.pdbx_redundancy 7.2 # _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.entry_id 2WIG _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.ls_number_reflns_obs 40659 _refine.ls_number_reflns_all ? _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F . _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 49.09 _refine.ls_d_res_high 2.15 _refine.ls_percent_reflns_obs 100.00 _refine.ls_R_factor_obs 0.19060 _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work 0.18868 _refine.ls_R_factor_R_free 0.25296 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 3.0 _refine.ls_number_reflns_R_free 1258 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc 0.953 _refine.correlation_coeff_Fo_to_Fc_free 0.925 _refine.B_iso_mean 35.280 _refine.aniso_B[1][1] 0.00 _refine.aniso_B[2][2] 0.00 _refine.aniso_B[3][3] 0.00 _refine.aniso_B[1][2] 0.00 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_details 'BABINET MODEL WITH MASK' _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.20 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details 'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.' _refine.pdbx_starting_model 'PDB ENTRY 1P0I' _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R 0.191 _refine.pdbx_overall_ESU_R_Free 0.187 _refine.overall_SU_ML 0.141 _refine.pdbx_overall_phase_error ? _refine.overall_SU_B 5.566 _refine.overall_SU_R_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 4202 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 164 _refine_hist.number_atoms_solvent 343 _refine_hist.number_atoms_total 4709 _refine_hist.d_res_high 2.15 _refine_hist.d_res_low 49.09 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function r_bond_refined_d 0.018 0.022 ? 4514 'X-RAY DIFFRACTION' ? r_bond_other_d ? ? ? ? 'X-RAY DIFFRACTION' ? r_angle_refined_deg 1.875 1.983 ? 6150 'X-RAY DIFFRACTION' ? r_angle_other_deg ? ? ? ? 'X-RAY DIFFRACTION' ? r_dihedral_angle_1_deg 6.778 5.000 ? 529 'X-RAY DIFFRACTION' ? r_dihedral_angle_2_deg 36.006 24.078 ? 206 'X-RAY DIFFRACTION' ? r_dihedral_angle_3_deg 17.521 15.000 ? 700 'X-RAY DIFFRACTION' ? r_dihedral_angle_4_deg 17.242 15.000 ? 22 'X-RAY DIFFRACTION' ? r_chiral_restr 0.144 0.200 ? 673 'X-RAY DIFFRACTION' ? r_gen_planes_refined 0.009 0.021 ? 3404 'X-RAY DIFFRACTION' ? r_gen_planes_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbd_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcbond_it 1.065 1.500 ? 2632 'X-RAY DIFFRACTION' ? r_mcbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcangle_it 1.929 2.000 ? 4251 'X-RAY DIFFRACTION' ? r_mcangle_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_scbond_it 2.820 3.000 ? 1882 'X-RAY DIFFRACTION' ? r_scbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_scangle_it 4.417 4.500 ? 1897 'X-RAY DIFFRACTION' ? r_scangle_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_long_range_B_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_long_range_B_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_rigid_bond_restr ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_free ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_bonded ? ? ? ? 'X-RAY DIFFRACTION' ? # _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.d_res_high 2.150 _refine_ls_shell.d_res_low 2.206 _refine_ls_shell.number_reflns_R_work 2927 _refine_ls_shell.R_factor_R_work 0.254 _refine_ls_shell.percent_reflns_obs 100.00 _refine_ls_shell.R_factor_R_free 0.363 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.number_reflns_R_free 91 _refine_ls_shell.number_reflns_all ? _refine_ls_shell.R_factor_all ? # _struct.entry_id 2WIG _struct.title 'NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA4' _struct.pdbx_descriptor 'CHOLINESTERASE (E.C.3.1.1.8)' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 2WIG _struct_keywords.pdbx_keywords HYDROLASE _struct_keywords.text 'AGING, HYDROLASE, INHIBITION, POLYMORPHISM, GLYCOPROTEIN, SERINE ESTERASE, DISEASE MUTATION' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 3 ? D N N 4 ? E N N 5 ? F N N 5 ? G N N 5 ? H N N 4 ? I N N 5 ? J N N 6 ? K N N 6 ? L N N 7 ? M N N 6 ? N N N 7 ? O N N 6 ? P N N 6 ? Q N N 6 ? R N N 6 ? S N N 6 ? T N N 7 ? U N N 8 ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 AA1 LEU A 38 ? ARG A 42 ? LEU A 38 ARG A 42 5 ? 5 HELX_P HELX_P2 AA2 PHE A 76 ? MET A 81 ? PHE A 76 MET A 81 1 ? 6 HELX_P HELX_P3 AA3 LEU A 125 ? ASP A 129 ? LEU A 125 ASP A 129 5 ? 5 HELX_P HELX_P4 AA4 GLY A 130 ? ARG A 138 ? GLY A 130 ARG A 138 1 ? 9 HELX_P HELX_P5 AA5 GLY A 149 ? LEU A 154 ? GLY A 149 LEU A 154 1 ? 6 HELX_P HELX_P6 AA6 ASN A 165 ? ILE A 182 ? ASN A 165 ILE A 182 1 ? 18 HELX_P HELX_P7 AA7 ALA A 183 ? PHE A 185 ? ALA A 183 PHE A 185 5 ? 3 HELX_P HELX_P8 AA8 SER A 198 ? SER A 210 ? SER A 198 SER A 210 1 ? 13 HELX_P HELX_P9 AA9 PRO A 211 ? PHE A 217 ? PRO A 211 PHE A 217 5 ? 7 HELX_P HELX_P10 AB1 SER A 235 ? THR A 250 ? SER A 235 THR A 250 1 ? 16 HELX_P HELX_P11 AB2 ASN A 256 ? ARG A 265 ? ASN A 256 ARG A 265 1 ? 10 HELX_P HELX_P12 AB3 ASP A 268 ? ALA A 277 ? ASP A 268 ALA A 277 1 ? 10 HELX_P HELX_P13 AB4 MET A 302 ? LEU A 309 ? MET A 302 LEU A 309 1 ? 8 HELX_P HELX_P14 AB5 GLY A 326 ? GLY A 333 ? GLY A 326 GLY A 333 5 ? 8 HELX_P HELX_P15 AB6 THR A 346 ? PHE A 358 ? THR A 346 PHE A 358 1 ? 13 HELX_P HELX_P16 AB7 SER A 362 ? THR A 374 ? SER A 362 THR A 374 1 ? 13 HELX_P HELX_P17 AB8 GLU A 383 ? PHE A 398 ? GLU A 383 PHE A 398 1 ? 16 HELX_P HELX_P18 AB9 PHE A 398 ? GLU A 411 ? PHE A 398 GLU A 411 1 ? 14 HELX_P HELX_P19 AC1 PRO A 431 ? GLY A 435 ? PRO A 431 GLY A 435 5 ? 5 HELX_P HELX_P20 AC2 GLU A 441 ? PHE A 446 ? GLU A 441 PHE A 446 1 ? 6 HELX_P HELX_P21 AC3 GLY A 447 ? GLN A 455 ? GLY A 447 GLN A 455 5 ? 9 HELX_P HELX_P22 AC4 THR A 457 ? GLY A 478 ? THR A 457 GLY A 478 1 ? 22 HELX_P HELX_P23 AC5 ARG A 515 ? SER A 524 ? ARG A 515 SER A 524 1 ? 10 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 65 SG ? ? ? 1_555 A CYS 92 SG ? ? A CYS 65 A CYS 92 1_555 ? ? ? ? ? ? ? 2.102 ? disulf2 disulf ? ? A CYS 252 SG ? ? ? 1_555 A CYS 263 SG ? ? A CYS 252 A CYS 263 1_555 ? ? ? ? ? ? ? 2.062 ? disulf3 disulf ? ? A CYS 400 SG ? ? ? 1_555 A CYS 519 SG ? ? A CYS 400 A CYS 519 1_555 ? ? ? ? ? ? ? 2.079 ? covale1 covale one ? A ASN 57 ND2 ? ? ? 1_555 O NAG . C1 ? ? A ASN 57 A NAG 614 1_555 ? ? ? ? ? ? ? 1.473 ? covale2 covale one ? A ASN 106 ND2 ? ? ? 1_555 M NAG . C1 ? ? A ASN 106 A NAG 612 1_555 ? ? ? ? ? ? ? 1.458 ? covale3 covale one ? A SER 198 OG ? ? ? 1_555 B TC3 . P ? ? A SER 198 A TC3 601 1_555 ? ? ? ? ? ? ? 1.649 ? covale4 covale one ? A ASN 241 ND2 ? ? ? 1_555 R NAG . C1 ? ? A ASN 241 A NAG 617 1_555 ? ? ? ? ? ? ? 1.469 ? covale5 covale one ? A ASN 256 ND2 ? ? ? 1_555 Q NAG . C1 ? ? A ASN 256 A NAG 616 1_555 ? ? ? ? ? ? ? 1.445 ? covale6 covale one ? A ASN 341 ND2 ? ? ? 1_555 J NAG . C1 ? ? A ASN 341 A NAG 609 1_555 ? ? ? ? ? ? ? 1.430 ? covale7 covale one ? A ASN 485 ND2 ? ? ? 1_555 P NAG . C1 ? ? A ASN 485 A NAG 615 1_555 ? ? ? ? ? ? ? 1.451 ? covale8 covale both ? J NAG . O4 ? ? ? 1_555 K NAG . C1 ? ? A NAG 609 A NAG 610 1_555 ? ? ? ? ? ? ? 1.420 ? covale9 covale one ? J NAG . O6 ? ? ? 1_555 L FUL . C1 ? ? A NAG 609 A FUL 611 1_555 ? ? ? ? ? ? ? 1.435 ? covale10 covale one ? M NAG . O6 ? ? ? 1_555 N FUL . C1 ? ? A NAG 612 A FUL 613 1_555 ? ? ? ? ? ? ? 1.444 ? covale11 covale both ? R NAG . O4 ? ? ? 1_555 S NAG . C1 ? ? A NAG 617 A NAG 618 1_555 ? ? ? ? ? ? ? 1.438 ? covale12 covale one ? R NAG . O6 ? ? ? 1_555 T FUL . C1 ? ? A NAG 617 A FUL 619 1_555 ? ? ? ? ? ? ? 1.440 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 THR 53 A . ? THR 53 A ASP 54 A ? ASP 54 A 1 -14.38 2 ALA 101 A . ? ALA 101 A PRO 102 A ? PRO 102 A 1 -0.65 3 VAL 377 A . ? VAL 377 A ASP 378 A ? ASP 378 A 1 3.47 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details AA1 ? 3 ? AA2 ? 11 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense AA1 1 2 ? anti-parallel AA1 2 3 ? parallel AA2 1 2 ? anti-parallel AA2 2 3 ? anti-parallel AA2 3 4 ? anti-parallel AA2 4 5 ? parallel AA2 5 6 ? parallel AA2 6 7 ? parallel AA2 7 8 ? parallel AA2 8 9 ? parallel AA2 9 10 ? parallel AA2 10 11 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id AA1 1 ILE A 5 ? THR A 8 ? ILE A 5 THR A 8 AA1 2 GLY A 11 ? ARG A 14 ? GLY A 11 ARG A 14 AA1 3 ILE A 55 ? ASN A 57 ? ILE A 55 ASN A 57 AA2 1 MET A 16 ? VAL A 20 ? MET A 16 VAL A 20 AA2 2 GLY A 23 ? PRO A 32 ? GLY A 23 PRO A 32 AA2 3 TYR A 94 ? ALA A 101 ? TYR A 94 ALA A 101 AA2 4 ILE A 140 ? MET A 144 ? ILE A 140 MET A 144 AA2 5 ALA A 107 ? ILE A 113 ? ALA A 107 ILE A 113 AA2 6 GLY A 187 ? GLU A 197 ? GLY A 187 GLU A 197 AA2 7 ARG A 219 ? GLN A 223 ? ARG A 219 GLN A 223 AA2 8 ILE A 317 ? ASN A 322 ? ILE A 317 ASN A 322 AA2 9 ALA A 416 ? PHE A 421 ? ALA A 416 PHE A 421 AA2 10 LYS A 499 ? LEU A 503 ? LYS A 499 LEU A 503 AA2 11 ILE A 510 ? THR A 512 ? ILE A 510 THR A 512 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id AA1 1 2 N THR A 8 ? N THR A 8 O GLY A 11 ? O GLY A 11 AA1 2 3 N ARG A 14 ? N ARG A 14 O TRP A 56 ? O TRP A 56 AA2 1 2 N LEU A 18 ? N LEU A 18 O VAL A 25 ? O VAL A 25 AA2 2 3 N PHE A 28 ? N PHE A 28 O VAL A 97 ? O VAL A 97 AA2 3 4 N ASN A 96 ? N ASN A 96 O SER A 143 ? O SER A 143 AA2 4 5 O VAL A 142 ? O VAL A 142 N TRP A 112 ? N TRP A 112 AA2 5 6 N VAL A 109 ? N VAL A 109 O THR A 193 ? O THR A 193 AA2 6 7 N LEU A 194 ? N LEU A 194 O ARG A 219 ? O ARG A 219 AA2 7 8 N LEU A 222 ? N LEU A 222 O LEU A 318 ? O LEU A 318 AA2 8 9 N VAL A 321 ? N VAL A 321 O PHE A 421 ? O PHE A 421 AA2 9 10 N TYR A 420 ? N TYR A 420 O LEU A 501 ? O LEU A 501 AA2 10 11 N TYR A 500 ? N TYR A 500 O MET A 511 ? O MET A 511 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 7 'BINDING SITE FOR RESIDUE TC3 A1530' AC2 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE NA A1531' AC3 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE SO4 A1532' AC4 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE CL A1533' AC5 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE CL A1534' AC6 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE CL A1535' AC7 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE SO4 A1536' AC8 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE NAG A1543' AC9 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE NAG A1544' BC1 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE NAG A1545' BC2 Software ? ? ? ? 7 'BINDING SITE FOR CHAIN A OF SUGAR BOUND TO ASN A 106 RESIDUES 1541 TO 1542' BC3 Software ? ? ? ? 9 'BINDING SITE FOR CHAIN A OF SUGAR BOUND TO ASN A 241 RESIDUES 1546 TO 1548' BC4 Software ? ? ? ? 4 'BINDING SITE FOR CHAIN A OF SUGAR BOUND TO ASN A 341 RESIDUES 1538 TO 1540' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 7 GLY A 116 ? GLY A 116 . ? 1_555 ? 2 AC1 7 GLY A 117 ? GLY A 117 . ? 1_555 ? 3 AC1 7 SER A 198 ? SER A 198 . ? 1_555 ? 4 AC1 7 ALA A 199 ? ALA A 199 . ? 1_555 ? 5 AC1 7 LEU A 286 ? LEU A 286 . ? 1_555 ? 6 AC1 7 PHE A 398 ? PHE A 398 . ? 1_555 ? 7 AC1 7 HIS A 438 ? HIS A 438 . ? 1_555 ? 8 AC2 1 PHE A 525 ? PHE A 525 . ? 1_555 ? 9 AC3 5 LYS A 323 ? LYS A 323 . ? 1_555 ? 10 AC3 5 TYR A 420 ? TYR A 420 . ? 1_555 ? 11 AC3 5 ARG A 515 ? ARG A 515 . ? 1_555 ? 12 AC3 5 HOH U . ? HOH A 843 . ? 1_555 ? 13 AC3 5 HOH U . ? HOH A 702 . ? 1_555 ? 14 AC4 2 HIS A 77 ? HIS A 77 . ? 1_555 ? 15 AC4 2 HOH U . ? HOH A 1029 . ? 1_555 ? 16 AC5 2 ASP A 378 ? ASP A 378 . ? 1_555 ? 17 AC5 2 GLN A 380 ? GLN A 380 . ? 1_555 ? 18 AC6 2 ARG A 515 ? ARG A 515 . ? 1_555 ? 19 AC6 2 HOH U . ? HOH A 970 . ? 1_555 ? 20 AC7 4 GLN A 316 ? GLN A 316 . ? 1_555 ? 21 AC7 4 GLY A 413 ? GLY A 413 . ? 1_555 ? 22 AC7 4 ASN A 414 ? ASN A 414 . ? 1_555 ? 23 AC7 4 ASN A 415 ? ASN A 415 . ? 1_555 ? 24 AC8 2 ASN A 57 ? ASN A 57 . ? 1_555 ? 25 AC8 2 HOH U . ? HOH A 726 . ? 1_555 ? 26 AC9 4 ARG A 465 ? ARG A 465 . ? 1_555 ? 27 AC9 4 ASN A 485 ? ASN A 485 . ? 1_555 ? 28 AC9 4 HOH U . ? HOH A 823 . ? 1_555 ? 29 AC9 4 HOH U . ? HOH A 945 . ? 1_555 ? 30 BC1 3 ASN A 256 ? ASN A 256 . ? 1_555 ? 31 BC1 3 GLU A 259 ? GLU A 259 . ? 1_555 ? 32 BC1 3 HOH U . ? HOH A 890 . ? 1_555 ? 33 BC2 7 ASN A 106 ? ASN A 106 . ? 1_555 ? 34 BC2 7 ASN A 188 ? ASN A 188 . ? 1_555 ? 35 BC2 7 LYS A 190 ? LYS A 190 . ? 1_555 ? 36 BC2 7 SER A 191 ? SER A 191 . ? 1_555 ? 37 BC2 7 LYS A 476 ? LYS A 476 . ? 1_555 ? 38 BC2 7 HOH U . ? HOH A 761 . ? 1_555 ? 39 BC2 7 HOH U . ? HOH A 911 . ? 1_555 ? 40 BC3 9 TYR A 237 ? TYR A 237 . ? 1_555 ? 41 BC3 9 ASN A 241 ? ASN A 241 . ? 1_555 ? 42 BC3 9 ASN A 245 ? ASN A 245 . ? 1_555 ? 43 BC3 9 LEU A 249 ? LEU A 249 . ? 1_555 ? 44 BC3 9 PHE A 278 ? PHE A 278 . ? 1_555 ? 45 BC3 9 HOH U . ? HOH A 801 . ? 1_555 ? 46 BC3 9 HOH U . ? HOH A 901 . ? 1_555 ? 47 BC3 9 HOH U . ? HOH A 735 . ? 1_555 ? 48 BC3 9 HOH U . ? HOH A 880 . ? 1_555 ? 49 BC4 4 GLY A 336 ? GLY A 336 . ? 1_555 ? 50 BC4 4 SER A 338 ? SER A 338 . ? 1_555 ? 51 BC4 4 ASN A 341 ? ASN A 341 . ? 1_555 ? 52 BC4 4 HOH U . ? HOH A 717 . ? 1_555 ? # _database_PDB_matrix.entry_id 2WIG _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 2WIG _atom_sites.fract_transf_matrix[1][1] 0.006451 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.006451 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.007884 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C CL N NA O P S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . ASP A 1 3 ? -37.944 -17.601 -49.467 1.00 64.84 ? 3 ASP A N 1 ATOM 2 C CA . ASP A 1 3 ? -36.779 -18.432 -49.901 1.00 65.20 ? 3 ASP A CA 1 ATOM 3 C C . ASP A 1 3 ? -35.424 -17.762 -49.602 1.00 64.33 ? 3 ASP A C 1 ATOM 4 O O . ASP A 1 3 ? -35.153 -16.654 -50.109 1.00 64.78 ? 3 ASP A O 1 ATOM 5 C CB . ASP A 1 3 ? -36.869 -18.739 -51.400 1.00 66.00 ? 3 ASP A CB 1 ATOM 6 C CG . ASP A 1 3 ? -35.909 -19.832 -51.823 1.00 67.79 ? 3 ASP A CG 1 ATOM 7 O OD1 . ASP A 1 3 ? -35.296 -20.464 -50.924 1.00 70.22 ? 3 ASP A OD1 1 ATOM 8 O OD2 . ASP A 1 3 ? -35.771 -20.062 -53.045 1.00 69.70 ? 3 ASP A OD2 1 ATOM 9 N N . ILE A 1 4 ? -34.567 -18.437 -48.818 1.00 62.24 ? 4 ILE A N 1 ATOM 10 C CA . ILE A 1 4 ? -33.334 -17.800 -48.307 1.00 59.93 ? 4 ILE A CA 1 ATOM 11 C C . ILE A 1 4 ? -32.032 -18.375 -48.850 1.00 58.02 ? 4 ILE A C 1 ATOM 12 O O . ILE A 1 4 ? -31.621 -19.479 -48.490 1.00 58.01 ? 4 ILE A O 1 ATOM 13 C CB . ILE A 1 4 ? -33.277 -17.856 -46.798 1.00 59.86 ? 4 ILE A CB 1 ATOM 14 C CG1 . ILE A 1 4 ? -34.637 -18.303 -46.264 1.00 60.09 ? 4 ILE A CG1 1 ATOM 15 C CG2 . ILE A 1 4 ? -32.832 -16.497 -46.254 1.00 60.64 ? 4 ILE A CG2 1 ATOM 16 C CD1 . ILE A 1 4 ? -35.154 -19.590 -46.933 1.00 58.98 ? 4 ILE A CD1 1 ATOM 17 N N . ILE A 1 5 ? -31.377 -17.609 -49.711 1.00 55.28 ? 5 ILE A N 1 ATOM 18 C CA . ILE A 1 5 ? -30.171 -18.066 -50.339 1.00 52.72 ? 5 ILE A CA 1 ATOM 19 C C . ILE A 1 5 ? -29.069 -17.133 -49.945 1.00 51.01 ? 5 ILE A C 1 ATOM 20 O O . ILE A 1 5 ? -29.215 -15.915 -49.998 1.00 50.58 ? 5 ILE A O 1 ATOM 21 C CB . ILE A 1 5 ? -30.294 -18.129 -51.868 1.00 52.51 ? 5 ILE A CB 1 ATOM 22 C CG1 . ILE A 1 5 ? -30.982 -19.425 -52.279 1.00 53.04 ? 5 ILE A CG1 1 ATOM 23 C CG2 . ILE A 1 5 ? -28.932 -18.081 -52.530 1.00 52.08 ? 5 ILE A CG2 1 ATOM 24 C CD1 . ILE A 1 5 ? -32.459 -19.276 -52.441 1.00 54.13 ? 5 ILE A CD1 1 ATOM 25 N N . ILE A 1 6 ? -27.960 -17.723 -49.524 1.00 49.16 ? 6 ILE A N 1 ATOM 26 C CA . ILE A 1 6 ? -26.819 -16.946 -49.105 1.00 47.65 ? 6 ILE A CA 1 ATOM 27 C C . ILE A 1 6 ? -25.670 -17.283 -50.021 1.00 47.81 ? 6 ILE A C 1 ATOM 28 O O . ILE A 1 6 ? -25.439 -18.435 -50.329 1.00 47.86 ? 6 ILE A O 1 ATOM 29 C CB . ILE A 1 6 ? -26.466 -17.231 -47.637 1.00 46.36 ? 6 ILE A CB 1 ATOM 30 C CG1 . ILE A 1 6 ? -27.649 -16.858 -46.751 1.00 44.43 ? 6 ILE A CG1 1 ATOM 31 C CG2 . ILE A 1 6 ? -25.215 -16.485 -47.221 1.00 45.91 ? 6 ILE A CG2 1 ATOM 32 C CD1 . ILE A 1 6 ? -27.911 -15.390 -46.621 1.00 39.04 ? 6 ILE A CD1 1 ATOM 33 N N . ALA A 1 7 ? -24.970 -16.271 -50.496 1.00 47.97 ? 7 ALA A N 1 ATOM 34 C CA . ALA A 1 7 ? -23.788 -16.529 -51.284 1.00 48.78 ? 7 ALA A CA 1 ATOM 35 C C . ALA A 1 7 ? -22.549 -16.697 -50.395 1.00 48.74 ? 7 ALA A C 1 ATOM 36 O O . ALA A 1 7 ? -22.180 -15.778 -49.676 1.00 48.78 ? 7 ALA A O 1 ATOM 37 C CB . ALA A 1 7 ? -23.581 -15.406 -52.304 1.00 49.13 ? 7 ALA A CB 1 ATOM 38 N N . THR A 1 8 ? -21.916 -17.868 -50.444 1.00 48.84 ? 8 THR A N 1 ATOM 39 C CA . THR A 1 8 ? -20.675 -18.101 -49.696 1.00 49.34 ? 8 THR A CA 1 ATOM 40 C C . THR A 1 8 ? -19.464 -18.071 -50.621 1.00 50.49 ? 8 THR A C 1 ATOM 41 O O . THR A 1 8 ? -19.612 -18.160 -51.829 1.00 50.94 ? 8 THR A O 1 ATOM 42 C CB . THR A 1 8 ? -20.694 -19.456 -48.916 1.00 49.04 ? 8 THR A CB 1 ATOM 43 O OG1 . THR A 1 8 ? -20.228 -20.535 -49.746 1.00 47.68 ? 8 THR A OG1 1 ATOM 44 C CG2 . THR A 1 8 ? -22.085 -19.749 -48.378 1.00 47.53 ? 8 THR A CG2 1 ATOM 45 N N . LYS A 1 9 ? -18.259 -17.959 -50.069 1.00 51.10 ? 9 LYS A N 1 ATOM 46 C CA . LYS A 1 9 ? -17.052 -18.041 -50.889 1.00 51.30 ? 9 LYS A CA 1 ATOM 47 C C . LYS A 1 9 ? -17.055 -19.249 -51.826 1.00 51.37 ? 9 LYS A C 1 ATOM 48 O O . LYS A 1 9 ? -16.446 -19.199 -52.889 1.00 51.41 ? 9 LYS A O 1 ATOM 49 C CB . LYS A 1 9 ? -15.806 -18.099 -49.999 1.00 51.26 ? 9 LYS A CB 1 ATOM 50 C CG . LYS A 1 9 ? -15.589 -16.819 -49.198 1.00 53.30 ? 9 LYS A CG 1 ATOM 51 C CD . LYS A 1 9 ? -14.869 -15.759 -50.005 1.00 56.16 ? 9 LYS A CD 1 ATOM 52 C CE . LYS A 1 9 ? -15.473 -14.373 -49.790 1.00 57.16 ? 9 LYS A CE 1 ATOM 53 N NZ . LYS A 1 9 ? -16.000 -14.247 -48.411 1.00 59.00 ? 9 LYS A NZ 1 ATOM 54 N N . ASN A 1 10 ? -17.715 -20.343 -51.440 1.00 50.99 ? 10 ASN A N 1 ATOM 55 C CA . ASN A 1 10 ? -17.633 -21.571 -52.234 1.00 50.64 ? 10 ASN A CA 1 ATOM 56 C C . ASN A 1 10 ? -18.870 -21.863 -53.059 1.00 49.68 ? 10 ASN A C 1 ATOM 57 O O . ASN A 1 10 ? -18.887 -22.792 -53.848 1.00 49.27 ? 10 ASN A O 1 ATOM 58 C CB . ASN A 1 10 ? -17.365 -22.761 -51.320 1.00 51.55 ? 10 ASN A CB 1 ATOM 59 C CG . ASN A 1 10 ? -16.112 -22.578 -50.502 1.00 52.97 ? 10 ASN A CG 1 ATOM 60 O OD1 . ASN A 1 10 ? -15.029 -22.935 -50.951 1.00 54.75 ? 10 ASN A OD1 1 ATOM 61 N ND2 . ASN A 1 10 ? -16.250 -22.010 -49.294 1.00 51.87 ? 10 ASN A ND2 1 ATOM 62 N N . GLY A 1 11 ? -19.915 -21.082 -52.857 1.00 48.32 ? 11 GLY A N 1 ATOM 63 C CA . GLY A 1 11 ? -21.092 -21.249 -53.650 1.00 47.72 ? 11 GLY A CA 1 ATOM 64 C C . GLY A 1 11 ? -22.276 -20.753 -52.876 1.00 47.62 ? 11 GLY A C 1 ATOM 65 O O . GLY A 1 11 ? -22.127 -20.254 -51.762 1.00 48.39 ? 11 GLY A O 1 ATOM 66 N N . LYS A 1 12 ? -23.456 -20.900 -53.464 1.00 46.83 ? 12 LYS A N 1 ATOM 67 C CA . LYS A 1 12 ? -24.688 -20.543 -52.812 1.00 46.14 ? 12 LYS A CA 1 ATOM 68 C C . LYS A 1 12 ? -25.239 -21.667 -51.941 1.00 45.58 ? 12 LYS A C 1 ATOM 69 O O . LYS A 1 12 ? -25.033 -22.859 -52.210 1.00 45.20 ? 12 LYS A O 1 ATOM 70 C CB . LYS A 1 12 ? -25.729 -20.154 -53.852 1.00 45.99 ? 12 LYS A CB 1 ATOM 71 C CG . LYS A 1 12 ? -25.461 -18.835 -54.512 1.00 48.74 ? 12 LYS A CG 1 ATOM 72 C CD . LYS A 1 12 ? -26.490 -18.608 -55.620 1.00 53.30 ? 12 LYS A CD 1 ATOM 73 C CE . LYS A 1 12 ? -26.618 -17.133 -55.992 1.00 54.90 ? 12 LYS A CE 1 ATOM 74 N NZ . LYS A 1 12 ? -27.999 -16.891 -56.545 1.00 56.60 ? 12 LYS A NZ 1 ATOM 75 N N . VAL A 1 13 ? -25.961 -21.286 -50.895 1.00 44.73 ? 13 VAL A N 1 ATOM 76 C CA . VAL A 1 13 ? -26.580 -22.277 -50.066 1.00 43.92 ? 13 VAL A CA 1 ATOM 77 C C . VAL A 1 13 ? -27.994 -21.848 -49.781 1.00 44.12 ? 13 VAL A C 1 ATOM 78 O O . VAL A 1 13 ? -28.262 -20.688 -49.514 1.00 44.93 ? 13 VAL A O 1 ATOM 79 C CB . VAL A 1 13 ? -25.733 -22.556 -48.757 1.00 44.44 ? 13 VAL A CB 1 ATOM 80 C CG1 . VAL A 1 13 ? -24.257 -22.800 -49.109 1.00 41.03 ? 13 VAL A CG1 1 ATOM 81 C CG2 . VAL A 1 13 ? -25.845 -21.414 -47.773 1.00 44.05 ? 13 VAL A CG2 1 ATOM 82 N N . ARG A 1 14 ? -28.924 -22.779 -49.858 1.00 44.26 ? 14 ARG A N 1 ATOM 83 C CA . ARG A 1 14 ? -30.293 -22.488 -49.466 1.00 44.02 ? 14 ARG A CA 1 ATOM 84 C C . ARG A 1 14 ? -30.585 -23.091 -48.070 1.00 43.16 ? 14 ARG A C 1 ATOM 85 O O . ARG A 1 14 ? -30.165 -24.195 -47.747 1.00 42.54 ? 14 ARG A O 1 ATOM 86 C CB . ARG A 1 14 ? -31.270 -23.028 -50.536 1.00 44.36 ? 14 ARG A CB 1 ATOM 87 C CG . ARG A 1 14 ? -32.705 -23.234 -50.036 1.00 46.93 ? 14 ARG A CG 1 ATOM 88 C CD . ARG A 1 14 ? -33.588 -23.923 -51.107 1.00 54.04 ? 14 ARG A CD 1 ATOM 89 N NE . ARG A 1 14 ? -33.851 -22.990 -52.209 1.00 58.98 ? 14 ARG A NE 1 ATOM 90 C CZ . ARG A 1 14 ? -33.368 -23.102 -53.447 1.00 60.34 ? 14 ARG A CZ 1 ATOM 91 N NH1 . ARG A 1 14 ? -32.609 -24.138 -53.793 1.00 58.94 ? 14 ARG A NH1 1 ATOM 92 N NH2 . ARG A 1 14 ? -33.667 -22.164 -54.346 1.00 62.16 ? 14 ARG A NH2 1 ATOM 93 N N . GLY A 1 15 ? -31.326 -22.360 -47.252 1.00 42.89 ? 15 GLY A N 1 ATOM 94 C CA . GLY A 1 15 ? -31.602 -22.771 -45.898 1.00 42.30 ? 15 GLY A CA 1 ATOM 95 C C . GLY A 1 15 ? -33.071 -23.026 -45.790 1.00 43.01 ? 15 GLY A C 1 ATOM 96 O O . GLY A 1 15 ? -33.754 -23.158 -46.810 1.00 43.11 ? 15 GLY A O 1 ATOM 97 N N . MET A 1 16 ? -33.568 -23.115 -44.573 1.00 42.30 ? 16 MET A N 1 ATOM 98 C CA . MET A 1 16 ? -34.962 -23.388 -44.373 1.00 43.37 ? 16 MET A CA 1 ATOM 99 C C . MET A 1 16 ? -35.479 -22.588 -43.180 1.00 43.29 ? 16 MET A C 1 ATOM 100 O O . MET A 1 16 ? -34.735 -22.322 -42.251 1.00 42.70 ? 16 MET A O 1 ATOM 101 C CB . MET A 1 16 ? -35.162 -24.901 -44.178 1.00 44.54 ? 16 MET A CB 1 ATOM 102 C CG . MET A 1 16 ? -34.966 -25.489 -42.760 1.00 46.69 ? 16 MET A CG 1 ATOM 103 S SD . MET A 1 16 ? -34.660 -27.274 -42.954 1.00 54.82 ? 16 MET A SD 1 ATOM 104 C CE . MET A 1 16 ? -35.339 -27.959 -41.440 1.00 52.99 ? 16 MET A CE 1 ATOM 105 N N . GLN A 1 17 ? -36.740 -22.187 -43.198 1.00 43.21 ? 17 GLN A N 1 ATOM 106 C CA . GLN A 1 17 ? -37.246 -21.360 -42.095 1.00 43.86 ? 17 GLN A CA 1 ATOM 107 C C . GLN A 1 17 ? -37.849 -22.234 -41.005 1.00 42.76 ? 17 GLN A C 1 ATOM 108 O O . GLN A 1 17 ? -38.445 -23.267 -41.306 1.00 42.74 ? 17 GLN A O 1 ATOM 109 C CB . GLN A 1 17 ? -38.292 -20.386 -42.616 1.00 44.87 ? 17 GLN A CB 1 ATOM 110 C CG . GLN A 1 17 ? -37.772 -19.505 -43.735 1.00 48.68 ? 17 GLN A CG 1 ATOM 111 C CD . GLN A 1 17 ? -36.935 -18.347 -43.207 1.00 54.49 ? 17 GLN A CD 1 ATOM 112 O OE1 . GLN A 1 17 ? -35.774 -18.174 -43.587 1.00 59.26 ? 17 GLN A OE1 1 ATOM 113 N NE2 . GLN A 1 17 ? -37.518 -17.555 -42.323 1.00 56.27 ? 17 GLN A NE2 1 ATOM 114 N N . LEU A 1 18 ? -37.698 -21.833 -39.749 1.00 41.29 ? 18 LEU A N 1 ATOM 115 C CA . LEU A 1 18 ? -38.196 -22.627 -38.643 1.00 40.74 ? 18 LEU A CA 1 ATOM 116 C C . LEU A 1 18 ? -39.003 -21.748 -37.714 1.00 40.84 ? 18 LEU A C 1 ATOM 117 O O . LEU A 1 18 ? -38.609 -20.635 -37.383 1.00 42.07 ? 18 LEU A O 1 ATOM 118 C CB . LEU A 1 18 ? -37.041 -23.233 -37.836 1.00 40.46 ? 18 LEU A CB 1 ATOM 119 C CG . LEU A 1 18 ? -35.970 -24.085 -38.493 1.00 39.75 ? 18 LEU A CG 1 ATOM 120 C CD1 . LEU A 1 18 ? -34.865 -24.500 -37.465 1.00 36.77 ? 18 LEU A CD1 1 ATOM 121 C CD2 . LEU A 1 18 ? -36.610 -25.309 -39.202 1.00 38.61 ? 18 LEU A CD2 1 ATOM 122 N N . THR A 1 19 ? -40.122 -22.244 -37.242 1.00 40.63 ? 19 THR A N 1 ATOM 123 C CA . THR A 1 19 ? -40.896 -21.465 -36.307 1.00 40.29 ? 19 THR A CA 1 ATOM 124 C C . THR A 1 19 ? -40.413 -21.846 -34.943 1.00 40.24 ? 19 THR A C 1 ATOM 125 O O . THR A 1 19 ? -40.387 -23.024 -34.585 1.00 39.99 ? 19 THR A O 1 ATOM 126 C CB . THR A 1 19 ? -42.375 -21.804 -36.436 1.00 41.19 ? 19 THR A CB 1 ATOM 127 O OG1 . THR A 1 19 ? -42.801 -21.387 -37.733 1.00 40.39 ? 19 THR A OG1 1 ATOM 128 C CG2 . THR A 1 19 ? -43.223 -21.072 -35.360 1.00 40.64 ? 19 THR A CG2 1 ATOM 129 N N . VAL A 1 20 ? -39.989 -20.852 -34.181 1.00 40.03 ? 20 VAL A N 1 ATOM 130 C CA . VAL A 1 20 ? -39.570 -21.121 -32.811 1.00 39.05 ? 20 VAL A CA 1 ATOM 131 C C . VAL A 1 20 ? -40.119 -20.023 -31.944 1.00 38.90 ? 20 VAL A C 1 ATOM 132 O O . VAL A 1 20 ? -39.802 -18.853 -32.141 1.00 37.26 ? 20 VAL A O 1 ATOM 133 C CB . VAL A 1 20 ? -38.024 -21.111 -32.648 1.00 38.92 ? 20 VAL A CB 1 ATOM 134 C CG1 . VAL A 1 20 ? -37.634 -21.813 -31.339 1.00 38.37 ? 20 VAL A CG1 1 ATOM 135 C CG2 . VAL A 1 20 ? -37.307 -21.701 -33.885 1.00 36.53 ? 20 VAL A CG2 1 ATOM 136 N N . PHE A 1 21 ? -40.936 -20.414 -30.978 1.00 39.78 ? 21 PHE A N 1 ATOM 137 C CA . PHE A 1 21 ? -41.440 -19.472 -30.002 1.00 41.31 ? 21 PHE A CA 1 ATOM 138 C C . PHE A 1 21 ? -42.057 -18.284 -30.721 1.00 41.84 ? 21 PHE A C 1 ATOM 139 O O . PHE A 1 21 ? -41.762 -17.138 -30.393 1.00 42.99 ? 21 PHE A O 1 ATOM 140 C CB . PHE A 1 21 ? -40.307 -18.964 -29.094 1.00 41.14 ? 21 PHE A CB 1 ATOM 141 C CG . PHE A 1 21 ? -39.567 -20.053 -28.355 1.00 41.83 ? 21 PHE A CG 1 ATOM 142 C CD1 . PHE A 1 21 ? -38.246 -19.842 -27.928 1.00 41.32 ? 21 PHE A CD1 1 ATOM 143 C CD2 . PHE A 1 21 ? -40.166 -21.269 -28.105 1.00 40.77 ? 21 PHE A CD2 1 ATOM 144 C CE1 . PHE A 1 21 ? -37.538 -20.837 -27.259 1.00 39.72 ? 21 PHE A CE1 1 ATOM 145 C CE2 . PHE A 1 21 ? -39.475 -22.271 -27.425 1.00 42.88 ? 21 PHE A CE2 1 ATOM 146 C CZ . PHE A 1 21 ? -38.151 -22.051 -26.999 1.00 41.70 ? 21 PHE A CZ 1 ATOM 147 N N . GLY A 1 22 ? -42.897 -18.559 -31.705 1.00 42.23 ? 22 GLY A N 1 ATOM 148 C CA . GLY A 1 22 ? -43.684 -17.530 -32.373 1.00 42.27 ? 22 GLY A CA 1 ATOM 149 C C . GLY A 1 22 ? -42.819 -16.570 -33.133 1.00 42.26 ? 22 GLY A C 1 ATOM 150 O O . GLY A 1 22 ? -43.149 -15.382 -33.272 1.00 43.95 ? 22 GLY A O 1 ATOM 151 N N . GLY A 1 23 ? -41.695 -17.056 -33.626 1.00 41.37 ? 23 GLY A N 1 ATOM 152 C CA . GLY A 1 23 ? -40.741 -16.175 -34.292 1.00 40.65 ? 23 GLY A CA 1 ATOM 153 C C . GLY A 1 23 ? -40.143 -17.051 -35.343 1.00 39.99 ? 23 GLY A C 1 ATOM 154 O O . GLY A 1 23 ? -40.589 -18.170 -35.506 1.00 40.84 ? 23 GLY A O 1 ATOM 155 N N . THR A 1 24 ? -39.145 -16.565 -36.059 1.00 39.54 ? 24 THR A N 1 ATOM 156 C CA . THR A 1 24 ? -38.506 -17.389 -37.049 1.00 38.88 ? 24 THR A CA 1 ATOM 157 C C . THR A 1 24 ? -37.000 -17.483 -36.969 1.00 38.26 ? 24 THR A C 1 ATOM 158 O O . THR A 1 24 ? -36.303 -16.473 -36.895 1.00 38.98 ? 24 THR A O 1 ATOM 159 C CB . THR A 1 24 ? -38.836 -16.892 -38.450 1.00 39.06 ? 24 THR A CB 1 ATOM 160 O OG1 . THR A 1 24 ? -40.257 -16.969 -38.616 1.00 42.15 ? 24 THR A OG1 1 ATOM 161 C CG2 . THR A 1 24 ? -38.196 -17.785 -39.461 1.00 36.99 ? 24 THR A CG2 1 ATOM 162 N N . VAL A 1 25 ? -36.493 -18.703 -37.101 1.00 37.27 ? 25 VAL A N 1 ATOM 163 C CA . VAL A 1 25 ? -35.061 -18.908 -37.264 1.00 35.79 ? 25 VAL A CA 1 ATOM 164 C C . VAL A 1 25 ? -34.787 -19.530 -38.613 1.00 35.63 ? 25 VAL A C 1 ATOM 165 O O . VAL A 1 25 ? -35.512 -20.417 -39.023 1.00 36.28 ? 25 VAL A O 1 ATOM 166 C CB . VAL A 1 25 ? -34.511 -19.851 -36.134 1.00 35.76 ? 25 VAL A CB 1 ATOM 167 C CG1 . VAL A 1 25 ? -33.081 -20.296 -36.442 1.00 32.42 ? 25 VAL A CG1 1 ATOM 168 C CG2 . VAL A 1 25 ? -34.598 -19.173 -34.817 1.00 32.15 ? 25 VAL A CG2 1 ATOM 169 N N . THR A 1 26 ? -33.722 -19.100 -39.285 1.00 35.26 ? 26 THR A N 1 ATOM 170 C CA . THR A 1 26 ? -33.239 -19.753 -40.502 1.00 34.85 ? 26 THR A CA 1 ATOM 171 C C . THR A 1 26 ? -32.044 -20.685 -40.216 1.00 35.14 ? 26 THR A C 1 ATOM 172 O O . THR A 1 26 ? -31.010 -20.247 -39.666 1.00 34.88 ? 26 THR A O 1 ATOM 173 C CB . THR A 1 26 ? -32.750 -18.713 -41.532 1.00 34.60 ? 26 THR A CB 1 ATOM 174 O OG1 . THR A 1 26 ? -33.650 -17.606 -41.533 1.00 35.48 ? 26 THR A OG1 1 ATOM 175 C CG2 . THR A 1 26 ? -32.648 -19.312 -42.913 1.00 33.79 ? 26 THR A CG2 1 ATOM 176 N N . ALA A 1 27 ? -32.204 -21.961 -40.598 1.00 34.31 ? 27 ALA A N 1 ATOM 177 C CA . ALA A 1 27 ? -31.253 -23.016 -40.305 1.00 33.74 ? 27 ALA A CA 1 ATOM 178 C C . ALA A 1 27 ? -30.667 -23.436 -41.615 1.00 34.12 ? 27 ALA A C 1 ATOM 179 O O . ALA A 1 27 ? -31.413 -23.652 -42.597 1.00 34.21 ? 27 ALA A O 1 ATOM 180 C CB . ALA A 1 27 ? -31.957 -24.179 -39.663 1.00 33.72 ? 27 ALA A CB 1 ATOM 181 N N . PHE A 1 28 ? -29.348 -23.503 -41.669 1.00 32.69 ? 28 PHE A N 1 ATOM 182 C CA . PHE A 1 28 ? -28.666 -24.006 -42.837 1.00 32.24 ? 28 PHE A CA 1 ATOM 183 C C . PHE A 1 28 ? -27.957 -25.249 -42.362 1.00 31.99 ? 28 PHE A C 1 ATOM 184 O O . PHE A 1 28 ? -26.839 -25.151 -41.841 1.00 33.03 ? 28 PHE A O 1 ATOM 185 C CB . PHE A 1 28 ? -27.625 -23.016 -43.318 1.00 32.27 ? 28 PHE A CB 1 ATOM 186 C CG . PHE A 1 28 ? -28.206 -21.744 -43.885 1.00 34.77 ? 28 PHE A CG 1 ATOM 187 C CD1 . PHE A 1 28 ? -28.629 -20.727 -43.045 1.00 35.15 ? 28 PHE A CD1 1 ATOM 188 C CD2 . PHE A 1 28 ? -28.280 -21.559 -45.261 1.00 36.07 ? 28 PHE A CD2 1 ATOM 189 C CE1 . PHE A 1 28 ? -29.161 -19.551 -43.548 1.00 36.99 ? 28 PHE A CE1 1 ATOM 190 C CE2 . PHE A 1 28 ? -28.793 -20.375 -45.785 1.00 40.19 ? 28 PHE A CE2 1 ATOM 191 C CZ . PHE A 1 28 ? -29.246 -19.368 -44.920 1.00 36.88 ? 28 PHE A CZ 1 ATOM 192 N N . LEU A 1 29 ? -28.634 -26.382 -42.465 1.00 29.44 ? 29 LEU A N 1 ATOM 193 C CA . LEU A 1 29 ? -28.131 -27.631 -41.962 1.00 29.74 ? 29 LEU A CA 1 ATOM 194 C C . LEU A 1 29 ? -27.284 -28.369 -43.018 1.00 30.90 ? 29 LEU A C 1 ATOM 195 O O . LEU A 1 29 ? -27.705 -28.502 -44.183 1.00 30.49 ? 29 LEU A O 1 ATOM 196 C CB . LEU A 1 29 ? -29.308 -28.524 -41.574 1.00 29.15 ? 29 LEU A CB 1 ATOM 197 C CG . LEU A 1 29 ? -30.293 -27.974 -40.539 1.00 28.95 ? 29 LEU A CG 1 ATOM 198 C CD1 . LEU A 1 29 ? -31.166 -29.047 -40.057 1.00 27.88 ? 29 LEU A CD1 1 ATOM 199 C CD2 . LEU A 1 29 ? -29.505 -27.416 -39.380 1.00 31.84 ? 29 LEU A CD2 1 ATOM 200 N N . GLY A 1 30 ? -26.110 -28.855 -42.611 1.00 31.05 ? 30 GLY A N 1 ATOM 201 C CA . GLY A 1 30 ? -25.279 -29.697 -43.447 1.00 31.44 ? 30 GLY A CA 1 ATOM 202 C C . GLY A 1 30 ? -24.598 -28.962 -44.585 1.00 33.30 ? 30 GLY A C 1 ATOM 203 O O . GLY A 1 30 ? -24.570 -29.463 -45.703 1.00 33.67 ? 30 GLY A O 1 ATOM 204 N N . ILE A 1 31 ? -23.992 -27.798 -44.326 1.00 33.33 ? 31 ILE A N 1 ATOM 205 C CA . ILE A 1 31 ? -23.098 -27.169 -45.337 1.00 33.30 ? 31 ILE A CA 1 ATOM 206 C C . ILE A 1 31 ? -21.699 -27.805 -45.312 1.00 33.88 ? 31 ILE A C 1 ATOM 207 O O . ILE A 1 31 ? -21.097 -27.967 -44.227 1.00 34.48 ? 31 ILE A O 1 ATOM 208 C CB . ILE A 1 31 ? -22.899 -25.673 -45.021 1.00 33.68 ? 31 ILE A CB 1 ATOM 209 C CG1 . ILE A 1 31 ? -24.211 -24.957 -44.765 1.00 32.73 ? 31 ILE A CG1 1 ATOM 210 C CG2 . ILE A 1 31 ? -22.031 -24.968 -46.063 1.00 35.18 ? 31 ILE A CG2 1 ATOM 211 C CD1 . ILE A 1 31 ? -23.981 -23.502 -44.409 1.00 33.01 ? 31 ILE A CD1 1 ATOM 212 N N . PRO A 1 32 ? -21.127 -28.122 -46.488 1.00 32.79 ? 32 PRO A N 1 ATOM 213 C CA . PRO A 1 32 ? -19.828 -28.792 -46.444 1.00 32.33 ? 32 PRO A CA 1 ATOM 214 C C . PRO A 1 32 ? -18.708 -27.792 -46.210 1.00 32.08 ? 32 PRO A C 1 ATOM 215 O O . PRO A 1 32 ? -18.801 -26.675 -46.676 1.00 32.33 ? 32 PRO A O 1 ATOM 216 C CB . PRO A 1 32 ? -19.688 -29.371 -47.873 1.00 32.72 ? 32 PRO A CB 1 ATOM 217 C CG . PRO A 1 32 ? -20.465 -28.371 -48.743 1.00 31.86 ? 32 PRO A CG 1 ATOM 218 C CD . PRO A 1 32 ? -21.640 -27.954 -47.872 1.00 33.28 ? 32 PRO A CD 1 ATOM 219 N N . TYR A 1 33 ? -17.629 -28.193 -45.557 1.00 32.10 ? 33 TYR A N 1 ATOM 220 C CA . TYR A 1 33 ? -16.571 -27.229 -45.230 1.00 31.36 ? 33 TYR A CA 1 ATOM 221 C C . TYR A 1 33 ? -15.200 -27.727 -45.638 1.00 32.16 ? 33 TYR A C 1 ATOM 222 O O . TYR A 1 33 ? -14.227 -26.962 -45.639 1.00 31.92 ? 33 TYR A O 1 ATOM 223 C CB . TYR A 1 33 ? -16.598 -26.807 -43.741 1.00 31.44 ? 33 TYR A CB 1 ATOM 224 C CG . TYR A 1 33 ? -16.209 -27.873 -42.720 1.00 26.32 ? 33 TYR A CG 1 ATOM 225 C CD1 . TYR A 1 33 ? -17.171 -28.625 -42.080 1.00 20.51 ? 33 TYR A CD1 1 ATOM 226 C CD2 . TYR A 1 33 ? -14.888 -28.053 -42.344 1.00 24.14 ? 33 TYR A CD2 1 ATOM 227 C CE1 . TYR A 1 33 ? -16.806 -29.596 -41.090 1.00 21.65 ? 33 TYR A CE1 1 ATOM 228 C CE2 . TYR A 1 33 ? -14.520 -29.017 -41.343 1.00 22.99 ? 33 TYR A CE2 1 ATOM 229 C CZ . TYR A 1 33 ? -15.490 -29.743 -40.712 1.00 19.73 ? 33 TYR A CZ 1 ATOM 230 O OH . TYR A 1 33 ? -15.099 -30.711 -39.787 1.00 27.09 ? 33 TYR A OH 1 ATOM 231 N N . ALA A 1 34 ? -15.126 -28.990 -46.059 1.00 32.18 ? 34 ALA A N 1 ATOM 232 C CA . ALA A 1 34 ? -13.865 -29.535 -46.596 1.00 32.63 ? 34 ALA A CA 1 ATOM 233 C C . ALA A 1 34 ? -14.116 -30.580 -47.720 1.00 33.23 ? 34 ALA A C 1 ATOM 234 O O . ALA A 1 34 ? -15.232 -31.016 -47.930 1.00 33.39 ? 34 ALA A O 1 ATOM 235 C CB . ALA A 1 34 ? -13.048 -30.172 -45.464 1.00 30.72 ? 34 ALA A CB 1 ATOM 236 N N . GLN A 1 35 ? -13.078 -31.022 -48.412 1.00 35.23 ? 35 GLN A N 1 ATOM 237 C CA . GLN A 1 35 ? -13.272 -32.124 -49.345 1.00 37.03 ? 35 GLN A CA 1 ATOM 238 C C . GLN A 1 35 ? -13.515 -33.360 -48.521 1.00 36.14 ? 35 GLN A C 1 ATOM 239 O O . GLN A 1 35 ? -12.798 -33.550 -47.519 1.00 36.36 ? 35 GLN A O 1 ATOM 240 C CB . GLN A 1 35 ? -12.008 -32.371 -50.166 1.00 37.44 ? 35 GLN A CB 1 ATOM 241 C CG . GLN A 1 35 ? -11.862 -31.438 -51.327 1.00 44.50 ? 35 GLN A CG 1 ATOM 242 C CD . GLN A 1 35 ? -10.489 -31.544 -51.892 1.00 51.21 ? 35 GLN A CD 1 ATOM 243 O OE1 . GLN A 1 35 ? -9.865 -32.614 -51.804 1.00 54.69 ? 35 GLN A OE1 1 ATOM 244 N NE2 . GLN A 1 35 ? -9.971 -30.442 -52.442 1.00 53.41 ? 35 GLN A NE2 1 ATOM 245 N N . PRO A 1 36 ? -14.467 -34.224 -48.944 1.00 35.41 ? 36 PRO A N 1 ATOM 246 C CA . PRO A 1 36 ? -14.714 -35.490 -48.246 1.00 34.81 ? 36 PRO A CA 1 ATOM 247 C C . PRO A 1 36 ? -13.376 -36.251 -48.030 1.00 34.43 ? 36 PRO A C 1 ATOM 248 O O . PRO A 1 36 ? -12.569 -36.322 -48.931 1.00 34.35 ? 36 PRO A O 1 ATOM 249 C CB . PRO A 1 36 ? -15.657 -36.220 -49.202 1.00 34.59 ? 36 PRO A CB 1 ATOM 250 C CG . PRO A 1 36 ? -16.433 -35.117 -49.847 1.00 34.28 ? 36 PRO A CG 1 ATOM 251 C CD . PRO A 1 36 ? -15.391 -34.047 -50.083 1.00 35.83 ? 36 PRO A CD 1 ATOM 252 N N . PRO A 1 37 ? -13.107 -36.741 -46.817 1.00 34.19 ? 37 PRO A N 1 ATOM 253 C CA . PRO A 1 37 ? -11.750 -37.260 -46.661 1.00 34.69 ? 37 PRO A CA 1 ATOM 254 C C . PRO A 1 37 ? -11.700 -38.746 -46.912 1.00 35.77 ? 37 PRO A C 1 ATOM 255 O O . PRO A 1 37 ? -11.453 -39.544 -45.990 1.00 35.83 ? 37 PRO A O 1 ATOM 256 C CB . PRO A 1 37 ? -11.417 -36.947 -45.205 1.00 34.49 ? 37 PRO A CB 1 ATOM 257 C CG . PRO A 1 37 ? -12.792 -36.978 -44.521 1.00 35.88 ? 37 PRO A CG 1 ATOM 258 C CD . PRO A 1 37 ? -13.765 -36.442 -45.530 1.00 33.82 ? 37 PRO A CD 1 ATOM 259 N N . LEU A 1 38 ? -11.938 -39.100 -48.172 1.00 37.26 ? 38 LEU A N 1 ATOM 260 C CA . LEU A 1 38 ? -12.082 -40.483 -48.628 1.00 38.52 ? 38 LEU A CA 1 ATOM 261 C C . LEU A 1 38 ? -10.879 -40.990 -49.375 1.00 39.07 ? 38 LEU A C 1 ATOM 262 O O . LEU A 1 38 ? -10.069 -40.233 -49.909 1.00 39.43 ? 38 LEU A O 1 ATOM 263 C CB . LEU A 1 38 ? -13.262 -40.578 -49.575 1.00 38.68 ? 38 LEU A CB 1 ATOM 264 C CG . LEU A 1 38 ? -14.504 -39.939 -49.016 1.00 40.00 ? 38 LEU A CG 1 ATOM 265 C CD1 . LEU A 1 38 ? -15.483 -39.652 -50.149 1.00 41.87 ? 38 LEU A CD1 1 ATOM 266 C CD2 . LEU A 1 38 ? -15.107 -40.884 -47.997 1.00 40.50 ? 38 LEU A CD2 1 ATOM 267 N N . GLY A 1 39 ? -10.781 -42.302 -49.451 1.00 39.95 ? 39 GLY A N 1 ATOM 268 C CA . GLY A 1 39 ? -9.751 -42.893 -50.285 1.00 39.82 ? 39 GLY A CA 1 ATOM 269 C C . GLY A 1 39 ? -8.372 -42.518 -49.834 1.00 40.26 ? 39 GLY A C 1 ATOM 270 O O . GLY A 1 39 ? -7.892 -42.951 -48.767 1.00 40.42 ? 39 GLY A O 1 ATOM 271 N N . ARG A 1 40 ? -7.708 -41.736 -50.668 1.00 40.46 ? 40 ARG A N 1 ATOM 272 C CA . ARG A 1 40 ? -6.302 -41.347 -50.465 1.00 40.45 ? 40 ARG A CA 1 ATOM 273 C C . ARG A 1 40 ? -6.150 -40.213 -49.426 1.00 39.96 ? 40 ARG A C 1 ATOM 274 O O . ARG A 1 40 ? -5.045 -39.948 -48.955 1.00 40.63 ? 40 ARG A O 1 ATOM 275 C CB . ARG A 1 40 ? -5.720 -40.930 -51.838 1.00 41.74 ? 40 ARG A CB 1 ATOM 276 C CG . ARG A 1 40 ? -4.771 -39.743 -51.858 1.00 43.50 ? 40 ARG A CG 1 ATOM 277 C CD . ARG A 1 40 ? -4.737 -39.064 -53.243 0.50 44.17 ? 40 ARG A CD 1 ATOM 278 N NE . ARG A 1 40 ? -5.826 -38.101 -53.470 0.50 45.32 ? 40 ARG A NE 1 ATOM 279 C CZ . ARG A 1 40 ? -5.717 -36.780 -53.284 0.50 44.86 ? 40 ARG A CZ 1 ATOM 280 N NH1 . ARG A 1 40 ? -4.574 -36.256 -52.842 0.50 44.86 ? 40 ARG A NH1 1 ATOM 281 N NH2 . ARG A 1 40 ? -6.749 -35.978 -53.525 0.50 43.25 ? 40 ARG A NH2 1 ATOM 282 N N . LEU A 1 41 ? -7.269 -39.556 -49.095 1.00 38.57 ? 41 LEU A N 1 ATOM 283 C CA . LEU A 1 41 ? -7.349 -38.499 -48.092 1.00 36.42 ? 41 LEU A CA 1 ATOM 284 C C . LEU A 1 41 ? -7.666 -39.030 -46.695 1.00 36.65 ? 41 LEU A C 1 ATOM 285 O O . LEU A 1 41 ? -7.595 -38.252 -45.719 1.00 36.48 ? 41 LEU A O 1 ATOM 286 C CB . LEU A 1 41 ? -8.433 -37.472 -48.471 1.00 36.19 ? 41 LEU A CB 1 ATOM 287 C CG . LEU A 1 41 ? -8.241 -36.769 -49.813 1.00 34.55 ? 41 LEU A CG 1 ATOM 288 C CD1 . LEU A 1 41 ? -9.316 -35.740 -50.080 1.00 31.42 ? 41 LEU A CD1 1 ATOM 289 C CD2 . LEU A 1 41 ? -6.831 -36.183 -49.873 1.00 34.24 ? 41 LEU A CD2 1 ATOM 290 N N . ARG A 1 42 ? -8.028 -40.321 -46.584 1.00 35.07 ? 42 ARG A N 1 ATOM 291 C CA . ARG A 1 42 ? -8.225 -40.930 -45.282 1.00 33.98 ? 42 ARG A CA 1 ATOM 292 C C . ARG A 1 42 ? -6.960 -40.786 -44.406 1.00 33.86 ? 42 ARG A C 1 ATOM 293 O O . ARG A 1 42 ? -5.829 -41.083 -44.870 1.00 33.50 ? 42 ARG A O 1 ATOM 294 C CB . ARG A 1 42 ? -8.657 -42.419 -45.392 1.00 33.89 ? 42 ARG A CB 1 ATOM 295 C CG . ARG A 1 42 ? -8.888 -43.059 -44.029 1.00 34.25 ? 42 ARG A CG 1 ATOM 296 C CD . ARG A 1 42 ? -9.019 -44.575 -43.989 1.00 32.77 ? 42 ARG A CD 1 ATOM 297 N NE . ARG A 1 42 ? -10.295 -45.000 -44.550 1.00 32.36 ? 42 ARG A NE 1 ATOM 298 C CZ . ARG A 1 42 ? -10.635 -46.270 -44.784 1.00 32.32 ? 42 ARG A CZ 1 ATOM 299 N NH1 . ARG A 1 42 ? -9.797 -47.263 -44.464 1.00 30.04 ? 42 ARG A NH1 1 ATOM 300 N NH2 . ARG A 1 42 ? -11.826 -46.540 -45.320 1.00 30.55 ? 42 ARG A NH2 1 ATOM 301 N N . PHE A 1 43 ? -7.169 -40.363 -43.144 1.00 32.70 ? 43 PHE A N 1 ATOM 302 C CA . PHE A 1 43 ? -6.105 -40.093 -42.138 1.00 31.62 ? 43 PHE A CA 1 ATOM 303 C C . PHE A 1 43 ? -5.280 -38.850 -42.422 1.00 31.78 ? 43 PHE A C 1 ATOM 304 O O . PHE A 1 43 ? -4.305 -38.578 -41.685 1.00 31.03 ? 43 PHE A O 1 ATOM 305 C CB . PHE A 1 43 ? -5.099 -41.227 -41.960 1.00 31.98 ? 43 PHE A CB 1 ATOM 306 C CG . PHE A 1 43 ? -5.704 -42.559 -41.668 1.00 33.10 ? 43 PHE A CG 1 ATOM 307 C CD1 . PHE A 1 43 ? -6.479 -42.755 -40.547 1.00 33.49 ? 43 PHE A CD1 1 ATOM 308 C CD2 . PHE A 1 43 ? -5.450 -43.642 -42.508 1.00 32.57 ? 43 PHE A CD2 1 ATOM 309 C CE1 . PHE A 1 43 ? -7.016 -44.009 -40.269 1.00 34.27 ? 43 PHE A CE1 1 ATOM 310 C CE2 . PHE A 1 43 ? -5.982 -44.887 -42.238 1.00 32.14 ? 43 PHE A CE2 1 ATOM 311 C CZ . PHE A 1 43 ? -6.771 -45.070 -41.132 1.00 32.72 ? 43 PHE A CZ 1 ATOM 312 N N . LYS A 1 44 ? -5.643 -38.102 -43.470 1.00 29.84 ? 44 LYS A N 1 ATOM 313 C CA . LYS A 1 44 ? -4.929 -36.891 -43.729 1.00 31.68 ? 44 LYS A CA 1 ATOM 314 C C . LYS A 1 44 ? -5.728 -35.696 -43.202 1.00 32.17 ? 44 LYS A C 1 ATOM 315 O O . LYS A 1 44 ? -6.947 -35.793 -42.953 1.00 31.78 ? 44 LYS A O 1 ATOM 316 C CB . LYS A 1 44 ? -4.620 -36.730 -45.241 1.00 31.73 ? 44 LYS A CB 1 ATOM 317 C CG . LYS A 1 44 ? -3.519 -37.704 -45.723 1.00 34.59 ? 44 LYS A CG 1 ATOM 318 C CD . LYS A 1 44 ? -3.350 -37.704 -47.215 1.00 37.52 ? 44 LYS A CD 1 ATOM 319 C CE . LYS A 1 44 ? -2.560 -36.521 -47.718 1.00 42.40 ? 44 LYS A CE 1 ATOM 320 N NZ . LYS A 1 44 ? -1.095 -36.768 -47.762 1.00 43.79 ? 44 LYS A NZ 1 ATOM 321 N N . LYS A 1 45 ? -5.000 -34.596 -43.020 1.00 32.81 ? 45 LYS A N 1 ATOM 322 C CA . LYS A 1 45 ? -5.523 -33.304 -42.671 1.00 33.87 ? 45 LYS A CA 1 ATOM 323 C C . LYS A 1 45 ? -6.586 -32.970 -43.718 1.00 35.28 ? 45 LYS A C 1 ATOM 324 O O . LYS A 1 45 ? -6.485 -33.419 -44.860 1.00 35.79 ? 45 LYS A O 1 ATOM 325 C CB . LYS A 1 45 ? -4.358 -32.279 -42.599 1.00 33.43 ? 45 LYS A CB 1 ATOM 326 C CG . LYS A 1 45 ? -3.516 -32.515 -41.308 1.00 33.96 ? 45 LYS A CG 1 ATOM 327 C CD . LYS A 1 45 ? -2.326 -31.609 -41.155 1.00 33.34 ? 45 LYS A CD 1 ATOM 328 C CE . LYS A 1 45 ? -2.612 -30.218 -41.671 1.00 32.82 ? 45 LYS A CE 1 ATOM 329 N NZ . LYS A 1 45 ? -1.534 -29.248 -41.330 1.00 33.15 ? 45 LYS A NZ 1 ATOM 330 N N . PRO A 1 46 ? -7.636 -32.243 -43.313 1.00 35.51 ? 46 PRO A N 1 ATOM 331 C CA . PRO A 1 46 ? -8.738 -31.921 -44.187 1.00 36.39 ? 46 PRO A CA 1 ATOM 332 C C . PRO A 1 46 ? -8.246 -30.976 -45.292 1.00 39.23 ? 46 PRO A C 1 ATOM 333 O O . PRO A 1 46 ? -7.393 -30.111 -45.033 1.00 38.81 ? 46 PRO A O 1 ATOM 334 C CB . PRO A 1 46 ? -9.717 -31.208 -43.247 1.00 36.51 ? 46 PRO A CB 1 ATOM 335 C CG . PRO A 1 46 ? -8.860 -30.634 -42.161 1.00 33.10 ? 46 PRO A CG 1 ATOM 336 C CD . PRO A 1 46 ? -7.754 -31.613 -41.991 1.00 34.66 ? 46 PRO A CD 1 ATOM 337 N N . GLN A 1 47 ? -8.757 -31.134 -46.514 1.00 41.14 ? 47 GLN A N 1 ATOM 338 C CA . GLN A 1 47 ? -8.313 -30.313 -47.628 1.00 43.20 ? 47 GLN A CA 1 ATOM 339 C C . GLN A 1 47 ? -9.407 -29.320 -47.959 1.00 44.90 ? 47 GLN A C 1 ATOM 340 O O . GLN A 1 47 ? -10.595 -29.622 -47.860 1.00 44.21 ? 47 GLN A O 1 ATOM 341 C CB . GLN A 1 47 ? -7.985 -31.174 -48.855 1.00 42.65 ? 47 GLN A CB 1 ATOM 342 C CG . GLN A 1 47 ? -7.147 -32.405 -48.538 1.00 44.96 ? 47 GLN A CG 1 ATOM 343 C CD . GLN A 1 47 ? -5.732 -32.055 -48.192 1.00 48.83 ? 47 GLN A CD 1 ATOM 344 O OE1 . GLN A 1 47 ? -5.164 -31.157 -48.826 1.00 50.37 ? 47 GLN A OE1 1 ATOM 345 N NE2 . GLN A 1 47 ? -5.135 -32.738 -47.167 1.00 47.70 ? 47 GLN A NE2 1 ATOM 346 N N . SER A 1 48 ? -9.015 -28.121 -48.353 1.00 47.79 ? 48 SER A N 1 ATOM 347 C CA . SER A 1 48 ? -9.995 -27.057 -48.541 1.00 50.90 ? 48 SER A CA 1 ATOM 348 C C . SER A 1 48 ? -10.958 -27.391 -49.687 1.00 52.59 ? 48 SER A C 1 ATOM 349 O O . SER A 1 48 ? -10.688 -28.250 -50.532 1.00 52.61 ? 48 SER A O 1 ATOM 350 C CB . SER A 1 48 ? -9.303 -25.710 -48.773 1.00 51.07 ? 48 SER A CB 1 ATOM 351 O OG . SER A 1 48 ? -8.820 -25.653 -50.115 1.00 53.37 ? 48 SER A OG 1 ATOM 352 N N . LEU A 1 49 ? -12.083 -26.691 -49.705 1.00 55.16 ? 49 LEU A N 1 ATOM 353 C CA . LEU A 1 49 ? -13.214 -27.068 -50.536 1.00 57.59 ? 49 LEU A CA 1 ATOM 354 C C . LEU A 1 49 ? -13.287 -26.183 -51.754 1.00 59.37 ? 49 LEU A C 1 ATOM 355 O O . LEU A 1 49 ? -13.060 -24.980 -51.640 1.00 59.44 ? 49 LEU A O 1 ATOM 356 C CB . LEU A 1 49 ? -14.484 -26.850 -49.741 1.00 57.57 ? 49 LEU A CB 1 ATOM 357 C CG . LEU A 1 49 ? -15.705 -27.444 -50.382 1.00 57.74 ? 49 LEU A CG 1 ATOM 358 C CD1 . LEU A 1 49 ? -15.441 -28.901 -50.757 1.00 57.66 ? 49 LEU A CD1 1 ATOM 359 C CD2 . LEU A 1 49 ? -16.855 -27.264 -49.398 1.00 58.60 ? 49 LEU A CD2 1 ATOM 360 N N . THR A 1 50 ? -13.624 -26.763 -52.906 1.00 61.02 ? 50 THR A N 1 ATOM 361 C CA . THR A 1 50 ? -13.735 -25.962 -54.123 1.00 62.88 ? 50 THR A CA 1 ATOM 362 C C . THR A 1 50 ? -15.185 -25.672 -54.550 1.00 63.63 ? 50 THR A C 1 ATOM 363 O O . THR A 1 50 ? -16.095 -26.476 -54.276 1.00 63.73 ? 50 THR A O 1 ATOM 364 C CB . THR A 1 50 ? -12.932 -26.577 -55.290 1.00 63.54 ? 50 THR A CB 1 ATOM 365 O OG1 . THR A 1 50 ? -12.586 -25.539 -56.226 1.00 64.23 ? 50 THR A OG1 1 ATOM 366 C CG2 . THR A 1 50 ? -13.727 -27.725 -55.981 1.00 63.77 ? 50 THR A CG2 1 ATOM 367 N N . LYS A 1 51 ? -15.389 -24.530 -55.219 1.00 64.16 ? 51 LYS A N 1 ATOM 368 C CA . LYS A 1 51 ? -16.738 -24.061 -55.605 1.00 64.71 ? 51 LYS A CA 1 ATOM 369 C C . LYS A 1 51 ? -17.665 -25.141 -56.202 1.00 65.23 ? 51 LYS A C 1 ATOM 370 O O . LYS A 1 51 ? -17.239 -25.948 -57.025 1.00 65.40 ? 51 LYS A O 1 ATOM 371 C CB . LYS A 1 51 ? -16.458 -22.970 -56.617 0.0000 20.00 ? 51 LYS A CB 1 ATOM 372 C CG . LYS A 1 51 ? -15.321 -22.040 -56.299 0.0000 20.00 ? 51 LYS A CG 1 ATOM 373 C CD . LYS A 1 51 ? -15.284 -20.856 -57.274 0.0000 20.00 ? 51 LYS A CD 1 ATOM 374 C CE . LYS A 1 51 ? -15.119 -19.516 -56.569 0.0000 20.00 ? 51 LYS A CE 1 ATOM 375 N NZ . LYS A 1 51 ? -15.754 -18.373 -57.299 0.0000 20.00 ? 51 LYS A NZ 1 ATOM 376 N N . TRP A 1 52 ? -18.915 -25.175 -55.735 1.00 65.45 ? 52 TRP A N 1 ATOM 377 C CA . TRP A 1 52 ? -20.034 -25.808 -56.444 1.00 65.21 ? 52 TRP A CA 1 ATOM 378 C C . TRP A 1 52 ? -20.814 -24.605 -56.965 1.00 65.57 ? 52 TRP A C 1 ATOM 379 O O . TRP A 1 52 ? -20.529 -23.475 -56.560 1.00 65.61 ? 52 TRP A O 1 ATOM 380 C CB . TRP A 1 52 ? -20.901 -26.612 -55.489 1.00 64.70 ? 52 TRP A CB 1 ATOM 381 C CG . TRP A 1 52 ? -21.598 -25.745 -54.501 1.00 64.40 ? 52 TRP A CG 1 ATOM 382 C CD1 . TRP A 1 52 ? -22.763 -25.042 -54.685 1.00 64.73 ? 52 TRP A CD1 1 ATOM 383 C CD2 . TRP A 1 52 ? -21.170 -25.464 -53.170 1.00 63.49 ? 52 TRP A CD2 1 ATOM 384 N NE1 . TRP A 1 52 ? -23.085 -24.346 -53.539 1.00 63.04 ? 52 TRP A NE1 1 ATOM 385 C CE2 . TRP A 1 52 ? -22.119 -24.589 -52.598 1.00 63.23 ? 52 TRP A CE2 1 ATOM 386 C CE3 . TRP A 1 52 ? -20.079 -25.879 -52.397 1.00 62.91 ? 52 TRP A CE3 1 ATOM 387 C CZ2 . TRP A 1 52 ? -22.006 -24.125 -51.290 1.00 62.65 ? 52 TRP A CZ2 1 ATOM 388 C CZ3 . TRP A 1 52 ? -19.977 -25.427 -51.099 1.00 60.73 ? 52 TRP A CZ3 1 ATOM 389 C CH2 . TRP A 1 52 ? -20.928 -24.556 -50.562 1.00 61.27 ? 52 TRP A CH2 1 ATOM 390 N N . THR A 1 53 ? -21.786 -24.775 -57.855 1.00 65.99 ? 53 THR A N 1 ATOM 391 C CA . THR A 1 53 ? -22.246 -23.545 -58.476 1.00 66.03 ? 53 THR A CA 1 ATOM 392 C C . THR A 1 53 ? -23.318 -23.535 -59.544 1.00 65.60 ? 53 THR A C 1 ATOM 393 O O . THR A 1 53 ? -23.000 -23.143 -60.674 1.00 65.78 ? 53 THR A O 1 ATOM 394 C CB . THR A 1 53 ? -21.033 -22.854 -59.145 1.00 66.70 ? 53 THR A CB 1 ATOM 395 O OG1 . THR A 1 53 ? -20.739 -23.502 -60.396 1.00 67.46 ? 53 THR A OG1 1 ATOM 396 C CG2 . THR A 1 53 ? -19.785 -22.893 -58.215 1.00 66.17 ? 53 THR A CG2 1 ATOM 397 N N . ASP A 1 54 ? -24.560 -23.939 -59.239 1.00 64.86 ? 54 ASP A N 1 ATOM 398 C CA . ASP A 1 54 ? -24.920 -24.679 -58.026 1.00 63.86 ? 54 ASP A CA 1 ATOM 399 C C . ASP A 1 54 ? -25.550 -23.884 -56.890 1.00 61.82 ? 54 ASP A C 1 ATOM 400 O O . ASP A 1 54 ? -24.941 -22.944 -56.389 1.00 61.22 ? 54 ASP A O 1 ATOM 401 C CB . ASP A 1 54 ? -23.704 -25.426 -57.489 1.00 64.77 ? 54 ASP A CB 1 ATOM 402 C CG . ASP A 1 54 ? -23.730 -26.901 -57.833 1.00 67.85 ? 54 ASP A CG 1 ATOM 403 O OD1 . ASP A 1 54 ? -24.709 -27.588 -57.442 1.00 70.40 ? 54 ASP A OD1 1 ATOM 404 O OD2 . ASP A 1 54 ? -22.759 -27.377 -58.477 1.00 72.01 ? 54 ASP A OD2 1 ATOM 405 N N . ILE A 1 55 ? -26.768 -24.267 -56.494 1.00 59.43 ? 55 ILE A N 1 ATOM 406 C CA . ILE A 1 55 ? -27.326 -23.860 -55.206 1.00 56.89 ? 55 ILE A CA 1 ATOM 407 C C . ILE A 1 55 ? -27.389 -25.051 -54.235 1.00 55.50 ? 55 ILE A C 1 ATOM 408 O O . ILE A 1 55 ? -28.298 -25.872 -54.337 1.00 55.00 ? 55 ILE A O 1 ATOM 409 C CB . ILE A 1 55 ? -28.742 -23.318 -55.303 1.00 56.97 ? 55 ILE A CB 1 ATOM 410 C CG1 . ILE A 1 55 ? -28.751 -21.891 -55.837 1.00 56.66 ? 55 ILE A CG1 1 ATOM 411 C CG2 . ILE A 1 55 ? -29.382 -23.340 -53.907 1.00 57.08 ? 55 ILE A CG2 1 ATOM 412 C CD1 . ILE A 1 55 ? -30.064 -21.174 -55.580 1.00 55.67 ? 55 ILE A CD1 1 ATOM 413 N N . TRP A 1 56 ? -26.433 -25.141 -53.294 1.00 53.04 ? 56 TRP A N 1 ATOM 414 C CA . TRP A 1 56 ? -26.424 -26.223 -52.306 1.00 49.51 ? 56 TRP A CA 1 ATOM 415 C C . TRP A 1 56 ? -27.611 -26.107 -51.361 1.00 48.80 ? 56 TRP A C 1 ATOM 416 O O . TRP A 1 56 ? -27.875 -25.058 -50.813 1.00 48.91 ? 56 TRP A O 1 ATOM 417 C CB . TRP A 1 56 ? -25.106 -26.263 -51.548 1.00 48.95 ? 56 TRP A CB 1 ATOM 418 C CG . TRP A 1 56 ? -25.096 -27.323 -50.527 1.00 45.32 ? 56 TRP A CG 1 ATOM 419 C CD1 . TRP A 1 56 ? -25.846 -27.369 -49.396 1.00 40.90 ? 56 TRP A CD1 1 ATOM 420 C CD2 . TRP A 1 56 ? -24.336 -28.526 -50.560 1.00 44.05 ? 56 TRP A CD2 1 ATOM 421 N NE1 . TRP A 1 56 ? -25.589 -28.524 -48.709 1.00 42.46 ? 56 TRP A NE1 1 ATOM 422 C CE2 . TRP A 1 56 ? -24.667 -29.258 -49.405 1.00 43.17 ? 56 TRP A CE2 1 ATOM 423 C CE3 . TRP A 1 56 ? -23.405 -29.058 -51.458 1.00 45.21 ? 56 TRP A CE3 1 ATOM 424 C CZ2 . TRP A 1 56 ? -24.096 -30.503 -49.109 1.00 45.21 ? 56 TRP A CZ2 1 ATOM 425 C CZ3 . TRP A 1 56 ? -22.828 -30.304 -51.164 1.00 46.50 ? 56 TRP A CZ3 1 ATOM 426 C CH2 . TRP A 1 56 ? -23.178 -31.007 -49.999 1.00 45.39 ? 56 TRP A CH2 1 ATOM 427 N N . ASN A 1 57 ? -28.360 -27.185 -51.216 1.00 48.44 ? 57 ASN A N 1 ATOM 428 C CA . ASN A 1 57 ? -29.572 -27.204 -50.396 1.00 48.60 ? 57 ASN A CA 1 ATOM 429 C C . ASN A 1 57 ? -29.203 -27.652 -48.968 1.00 46.60 ? 57 ASN A C 1 ATOM 430 O O . ASN A 1 57 ? -28.881 -28.816 -48.757 1.00 46.58 ? 57 ASN A O 1 ATOM 431 C CB . ASN A 1 57 ? -30.602 -28.179 -51.012 1.00 49.90 ? 57 ASN A CB 1 ATOM 432 C CG . ASN A 1 57 ? -31.423 -27.542 -52.146 1.00 56.58 ? 57 ASN A CG 1 ATOM 433 O OD1 . ASN A 1 57 ? -31.368 -26.314 -52.337 1.00 60.22 ? 57 ASN A OD1 1 ATOM 434 N ND2 . ASN A 1 57 ? -32.180 -28.376 -52.911 1.00 64.79 ? 57 ASN A ND2 1 ATOM 435 N N . ALA A 1 58 ? -29.202 -26.739 -47.997 1.00 44.16 ? 58 ALA A N 1 ATOM 436 C CA . ALA A 1 58 ? -28.770 -27.100 -46.638 1.00 41.90 ? 58 ALA A CA 1 ATOM 437 C C . ALA A 1 58 ? -29.993 -27.251 -45.749 1.00 40.42 ? 58 ALA A C 1 ATOM 438 O O . ALA A 1 58 ? -30.304 -26.392 -44.896 1.00 40.04 ? 58 ALA A O 1 ATOM 439 C CB . ALA A 1 58 ? -27.812 -26.061 -46.089 1.00 42.02 ? 58 ALA A CB 1 ATOM 440 N N . THR A 1 59 ? -30.702 -28.348 -45.966 1.00 38.17 ? 59 THR A N 1 ATOM 441 C CA . THR A 1 59 ? -32.077 -28.447 -45.490 1.00 36.57 ? 59 THR A CA 1 ATOM 442 C C . THR A 1 59 ? -32.206 -29.661 -44.612 1.00 35.69 ? 59 THR A C 1 ATOM 443 O O . THR A 1 59 ? -33.249 -29.910 -43.996 1.00 36.15 ? 59 THR A O 1 ATOM 444 C CB . THR A 1 59 ? -33.087 -28.451 -46.691 1.00 37.68 ? 59 THR A CB 1 ATOM 445 O OG1 . THR A 1 59 ? -32.519 -29.192 -47.785 1.00 37.28 ? 59 THR A OG1 1 ATOM 446 C CG2 . THR A 1 59 ? -33.274 -27.023 -47.192 1.00 34.88 ? 59 THR A CG2 1 ATOM 447 N N . LYS A 1 60 ? -31.119 -30.406 -44.499 1.00 34.10 ? 60 LYS A N 1 ATOM 448 C CA . LYS A 1 60 ? -31.100 -31.461 -43.504 1.00 33.72 ? 60 LYS A CA 1 ATOM 449 C C . LYS A 1 60 ? -29.697 -31.691 -42.931 1.00 31.76 ? 60 LYS A C 1 ATOM 450 O O . LYS A 1 60 ? -28.699 -31.370 -43.566 1.00 30.28 ? 60 LYS A O 1 ATOM 451 C CB . LYS A 1 60 ? -31.692 -32.764 -44.087 1.00 33.95 ? 60 LYS A CB 1 ATOM 452 C CG . LYS A 1 60 ? -30.969 -33.289 -45.274 1.00 36.67 ? 60 LYS A CG 1 ATOM 453 C CD . LYS A 1 60 ? -31.542 -34.682 -45.619 1.00 43.94 ? 60 LYS A CD 1 ATOM 454 C CE . LYS A 1 60 ? -31.164 -35.133 -47.055 1.00 47.73 ? 60 LYS A CE 1 ATOM 455 N NZ . LYS A 1 60 ? -29.680 -35.251 -47.281 1.00 49.05 ? 60 LYS A NZ 1 ATOM 456 N N . TYR A 1 61 ? -29.641 -32.260 -41.739 1.00 30.15 ? 61 TYR A N 1 ATOM 457 C CA . TYR A 1 61 ? -28.341 -32.636 -41.153 1.00 29.56 ? 61 TYR A CA 1 ATOM 458 C C . TYR A 1 61 ? -27.584 -33.590 -42.049 1.00 29.12 ? 61 TYR A C 1 ATOM 459 O O . TYR A 1 61 ? -28.185 -34.432 -42.661 1.00 28.56 ? 61 TYR A O 1 ATOM 460 C CB . TYR A 1 61 ? -28.600 -33.330 -39.838 1.00 29.43 ? 61 TYR A CB 1 ATOM 461 C CG . TYR A 1 61 ? -29.038 -32.419 -38.702 1.00 30.44 ? 61 TYR A CG 1 ATOM 462 C CD1 . TYR A 1 61 ? -28.224 -31.387 -38.256 1.00 29.49 ? 61 TYR A CD1 1 ATOM 463 C CD2 . TYR A 1 61 ? -30.234 -32.631 -38.049 1.00 30.15 ? 61 TYR A CD2 1 ATOM 464 C CE1 . TYR A 1 61 ? -28.609 -30.561 -37.166 1.00 27.68 ? 61 TYR A CE1 1 ATOM 465 C CE2 . TYR A 1 61 ? -30.620 -31.825 -36.994 1.00 30.34 ? 61 TYR A CE2 1 ATOM 466 C CZ . TYR A 1 61 ? -29.793 -30.795 -36.555 1.00 29.96 ? 61 TYR A CZ 1 ATOM 467 O OH . TYR A 1 61 ? -30.186 -30.017 -35.477 1.00 29.49 ? 61 TYR A OH 1 ATOM 468 N N . ALA A 1 62 ? -26.271 -33.470 -42.130 1.00 29.19 ? 62 ALA A N 1 ATOM 469 C CA . ALA A 1 62 ? -25.469 -34.364 -42.957 1.00 28.46 ? 62 ALA A CA 1 ATOM 470 C C . ALA A 1 62 ? -25.142 -35.678 -42.265 1.00 29.53 ? 62 ALA A C 1 ATOM 471 O O . ALA A 1 62 ? -25.608 -35.941 -41.136 1.00 30.34 ? 62 ALA A O 1 ATOM 472 C CB . ALA A 1 62 ? -24.182 -33.658 -43.422 1.00 28.61 ? 62 ALA A CB 1 ATOM 473 N N . ASN A 1 63 ? -24.402 -36.550 -42.947 1.00 28.07 ? 63 ASN A N 1 ATOM 474 C CA . ASN A 1 63 ? -23.908 -37.735 -42.296 1.00 28.48 ? 63 ASN A CA 1 ATOM 475 C C . ASN A 1 63 ? -23.023 -37.396 -41.081 1.00 28.61 ? 63 ASN A C 1 ATOM 476 O O . ASN A 1 63 ? -22.241 -36.450 -41.148 1.00 27.16 ? 63 ASN A O 1 ATOM 477 C CB . ASN A 1 63 ? -22.980 -38.494 -43.218 1.00 29.48 ? 63 ASN A CB 1 ATOM 478 C CG . ASN A 1 63 ? -23.646 -38.904 -44.537 1.00 30.83 ? 63 ASN A CG 1 ATOM 479 O OD1 . ASN A 1 63 ? -24.863 -39.019 -44.633 1.00 29.79 ? 63 ASN A OD1 1 ATOM 480 N ND2 . ASN A 1 63 ? -22.831 -39.098 -45.548 1.00 30.06 ? 63 ASN A ND2 1 ATOM 481 N N . SER A 1 64 ? -23.079 -38.255 -40.053 1.00 27.53 ? 64 SER A N 1 ATOM 482 C CA . SER A 1 64 ? -22.158 -38.235 -38.941 1.00 27.51 ? 64 SER A CA 1 ATOM 483 C C . SER A 1 64 ? -20.905 -39.018 -39.329 1.00 28.27 ? 64 SER A C 1 ATOM 484 O O . SER A 1 64 ? -20.974 -39.896 -40.209 1.00 29.00 ? 64 SER A O 1 ATOM 485 C CB . SER A 1 64 ? -22.833 -38.921 -37.743 1.00 27.32 ? 64 SER A CB 1 ATOM 486 O OG . SER A 1 64 ? -24.002 -38.222 -37.405 1.00 24.35 ? 64 SER A OG 1 ATOM 487 N N . CYS A 1 65 ? -19.773 -38.739 -38.680 1.00 26.43 ? 65 CYS A N 1 ATOM 488 C CA . CYS A 1 65 ? -18.551 -39.456 -38.952 1.00 25.77 ? 65 CYS A CA 1 ATOM 489 C C . CYS A 1 65 ? -18.649 -40.901 -38.433 1.00 25.82 ? 65 CYS A C 1 ATOM 490 O O . CYS A 1 65 ? -19.407 -41.194 -37.481 1.00 24.81 ? 65 CYS A O 1 ATOM 491 C CB . CYS A 1 65 ? -17.339 -38.705 -38.337 1.00 26.89 ? 65 CYS A CB 1 ATOM 492 S SG . CYS A 1 65 ? -17.132 -37.000 -39.044 1.00 27.40 ? 65 CYS A SG 1 ATOM 493 N N . CYS A 1 66 ? -17.873 -41.800 -39.038 1.00 25.74 ? 66 CYS A N 1 ATOM 494 C CA . CYS A 1 66 ? -17.875 -43.196 -38.620 1.00 27.84 ? 66 CYS A CA 1 ATOM 495 C C . CYS A 1 66 ? -17.508 -43.273 -37.162 1.00 28.63 ? 66 CYS A C 1 ATOM 496 O O . CYS A 1 66 ? -16.647 -42.508 -36.688 1.00 29.00 ? 66 CYS A O 1 ATOM 497 C CB . CYS A 1 66 ? -16.838 -43.995 -39.423 1.00 28.98 ? 66 CYS A CB 1 ATOM 498 S SG . CYS A 1 66 ? -17.187 -43.985 -41.200 1.00 34.30 ? 66 CYS A SG 1 ATOM 499 N N . GLN A 1 67 ? -18.124 -44.199 -36.447 1.00 28.23 ? 67 GLN A N 1 ATOM 500 C CA . GLN A 1 67 ? -17.837 -44.313 -35.028 1.00 28.17 ? 67 GLN A CA 1 ATOM 501 C C . GLN A 1 67 ? -18.581 -45.540 -34.475 1.00 28.14 ? 67 GLN A C 1 ATOM 502 O O . GLN A 1 67 ? -19.648 -45.895 -34.971 1.00 27.97 ? 67 GLN A O 1 ATOM 503 C CB . GLN A 1 67 ? -18.318 -43.040 -34.298 1.00 27.54 ? 67 GLN A CB 1 ATOM 504 C CG . GLN A 1 67 ? -19.759 -42.698 -34.637 1.00 25.44 ? 67 GLN A CG 1 ATOM 505 C CD . GLN A 1 67 ? -20.227 -41.367 -33.997 1.00 26.48 ? 67 GLN A CD 1 ATOM 506 O OE1 . GLN A 1 67 ? -20.648 -41.346 -32.838 1.00 21.35 ? 67 GLN A OE1 1 ATOM 507 N NE2 . GLN A 1 67 ? -20.195 -40.267 -34.778 1.00 24.33 ? 67 GLN A NE2 1 ATOM 508 N N . ASN A 1 68 ? -17.994 -46.173 -33.470 1.00 27.25 ? 68 ASN A N 1 ATOM 509 C CA . ASN A 1 68 ? -18.680 -47.179 -32.742 1.00 28.52 ? 68 ASN A CA 1 ATOM 510 C C . ASN A 1 68 ? -19.800 -46.556 -32.007 1.00 28.97 ? 68 ASN A C 1 ATOM 511 O O . ASN A 1 68 ? -19.757 -45.379 -31.715 1.00 29.42 ? 68 ASN A O 1 ATOM 512 C CB . ASN A 1 68 ? -17.710 -47.903 -31.813 1.00 28.02 ? 68 ASN A CB 1 ATOM 513 C CG . ASN A 1 68 ? -16.690 -48.703 -32.612 1.00 31.68 ? 68 ASN A CG 1 ATOM 514 O OD1 . ASN A 1 68 ? -17.077 -49.591 -33.401 1.00 36.80 ? 68 ASN A OD1 1 ATOM 515 N ND2 . ASN A 1 68 ? -15.402 -48.361 -32.488 1.00 30.41 ? 68 ASN A ND2 1 ATOM 516 N N . ILE A 1 69 ? -20.807 -47.360 -31.692 1.00 30.95 ? 69 ILE A N 1 ATOM 517 C CA . ILE A 1 69 ? -22.018 -46.900 -31.047 1.00 32.59 ? 69 ILE A CA 1 ATOM 518 C C . ILE A 1 69 ? -22.209 -47.580 -29.694 1.00 32.64 ? 69 ILE A C 1 ATOM 519 O O . ILE A 1 69 ? -21.803 -48.710 -29.506 1.00 32.80 ? 69 ILE A O 1 ATOM 520 C CB . ILE A 1 69 ? -23.226 -47.202 -31.936 1.00 33.14 ? 69 ILE A CB 1 ATOM 521 C CG1 . ILE A 1 69 ? -23.569 -45.998 -32.814 1.00 35.09 ? 69 ILE A CG1 1 ATOM 522 C CG2 . ILE A 1 69 ? -24.417 -47.497 -31.104 1.00 35.57 ? 69 ILE A CG2 1 ATOM 523 C CD1 . ILE A 1 69 ? -22.908 -46.012 -34.107 1.00 31.33 ? 69 ILE A CD1 1 ATOM 524 N N . ASP A 1 70 ? -22.855 -46.889 -28.761 1.00 33.20 ? 70 ASP A N 1 ATOM 525 C CA . ASP A 1 70 ? -23.139 -47.453 -27.432 1.00 34.44 ? 70 ASP A CA 1 ATOM 526 C C . ASP A 1 70 ? -24.388 -48.391 -27.455 1.00 34.89 ? 70 ASP A C 1 ATOM 527 O O . ASP A 1 70 ? -25.526 -47.893 -27.533 1.00 35.63 ? 70 ASP A O 1 ATOM 528 C CB . ASP A 1 70 ? -23.330 -46.298 -26.418 1.00 33.52 ? 70 ASP A CB 1 ATOM 529 C CG . ASP A 1 70 ? -23.769 -46.783 -25.060 1.00 34.57 ? 70 ASP A CG 1 ATOM 530 O OD1 . ASP A 1 70 ? -24.187 -45.948 -24.230 1.00 32.42 ? 70 ASP A OD1 1 ATOM 531 O OD2 . ASP A 1 70 ? -23.659 -48.004 -24.803 1.00 36.97 ? 70 ASP A OD2 1 ATOM 532 N N . GLN A 1 71 ? -24.157 -49.713 -27.395 1.00 34.91 ? 71 GLN A N 1 ATOM 533 C CA . GLN A 1 71 ? -25.201 -50.775 -27.435 1.00 35.34 ? 71 GLN A CA 1 ATOM 534 C C . GLN A 1 71 ? -25.392 -51.389 -26.067 1.00 35.28 ? 71 GLN A C 1 ATOM 535 O O . GLN A 1 71 ? -25.947 -52.480 -25.956 1.00 35.38 ? 71 GLN A O 1 ATOM 536 C CB . GLN A 1 71 ? -24.775 -51.939 -28.338 1.00 35.03 ? 71 GLN A CB 1 ATOM 537 C CG . GLN A 1 71 ? -24.240 -51.525 -29.741 1.00 37.63 ? 71 GLN A CG 1 ATOM 538 C CD . GLN A 1 71 ? -23.266 -52.571 -30.372 1.00 38.42 ? 71 GLN A CD 1 ATOM 539 O OE1 . GLN A 1 71 ? -23.344 -53.762 -30.097 0.50 38.50 ? 71 GLN A OE1 1 ATOM 540 N NE2 . GLN A 1 71 ? -22.363 -52.095 -31.236 0.50 37.44 ? 71 GLN A NE2 1 ATOM 541 N N . SER A 1 72 ? -24.914 -50.720 -25.019 1.00 33.83 ? 72 SER A N 1 ATOM 542 C CA . SER A 1 72 ? -25.111 -51.250 -23.676 1.00 33.72 ? 72 SER A CA 1 ATOM 543 C C . SER A 1 72 ? -26.566 -51.312 -23.274 1.00 33.12 ? 72 SER A C 1 ATOM 544 O O . SER A 1 72 ? -26.972 -52.288 -22.693 1.00 34.09 ? 72 SER A O 1 ATOM 545 C CB . SER A 1 72 ? -24.280 -50.482 -22.611 1.00 33.58 ? 72 SER A CB 1 ATOM 546 O OG . SER A 1 72 ? -22.936 -50.461 -23.045 1.00 33.80 ? 72 SER A OG 1 ATOM 547 N N . PHE A 1 73 ? -27.357 -50.294 -23.568 1.00 31.99 ? 73 PHE A N 1 ATOM 548 C CA . PHE A 1 73 ? -28.737 -50.294 -23.091 1.00 32.33 ? 73 PHE A CA 1 ATOM 549 C C . PHE A 1 73 ? -29.717 -50.137 -24.244 1.00 32.06 ? 73 PHE A C 1 ATOM 550 O O . PHE A 1 73 ? -30.369 -49.108 -24.362 1.00 31.57 ? 73 PHE A O 1 ATOM 551 C CB . PHE A 1 73 ? -28.908 -49.169 -22.045 1.00 32.97 ? 73 PHE A CB 1 ATOM 552 C CG . PHE A 1 73 ? -27.886 -49.245 -20.916 1.00 33.14 ? 73 PHE A CG 1 ATOM 553 C CD1 . PHE A 1 73 ? -27.960 -50.259 -19.959 1.00 34.48 ? 73 PHE A CD1 1 ATOM 554 C CD2 . PHE A 1 73 ? -26.849 -48.337 -20.837 1.00 29.93 ? 73 PHE A CD2 1 ATOM 555 C CE1 . PHE A 1 73 ? -27.027 -50.357 -18.937 1.00 33.64 ? 73 PHE A CE1 1 ATOM 556 C CE2 . PHE A 1 73 ? -25.907 -48.447 -19.840 1.00 32.43 ? 73 PHE A CE2 1 ATOM 557 C CZ . PHE A 1 73 ? -25.994 -49.450 -18.880 1.00 32.82 ? 73 PHE A CZ 1 ATOM 558 N N . PRO A 1 74 ? -29.791 -51.140 -25.145 1.00 32.75 ? 74 PRO A N 1 ATOM 559 C CA . PRO A 1 74 ? -30.678 -50.956 -26.322 1.00 31.65 ? 74 PRO A CA 1 ATOM 560 C C . PRO A 1 74 ? -32.056 -50.591 -25.841 1.00 31.17 ? 74 PRO A C 1 ATOM 561 O O . PRO A 1 74 ? -32.535 -51.172 -24.873 1.00 31.61 ? 74 PRO A O 1 ATOM 562 C CB . PRO A 1 74 ? -30.702 -52.339 -26.968 1.00 31.47 ? 74 PRO A CB 1 ATOM 563 C CG . PRO A 1 74 ? -29.415 -52.974 -26.561 1.00 34.04 ? 74 PRO A CG 1 ATOM 564 C CD . PRO A 1 74 ? -29.113 -52.454 -25.146 1.00 31.60 ? 74 PRO A CD 1 ATOM 565 N N . GLY A 1 75 ? -32.663 -49.569 -26.438 1.00 31.06 ? 75 GLY A N 1 ATOM 566 C CA . GLY A 1 75 ? -34.029 -49.219 -26.091 1.00 30.16 ? 75 GLY A CA 1 ATOM 567 C C . GLY A 1 75 ? -34.122 -48.131 -25.063 1.00 29.76 ? 75 GLY A C 1 ATOM 568 O O . GLY A 1 75 ? -35.172 -47.570 -24.847 1.00 29.19 ? 75 GLY A O 1 ATOM 569 N N . PHE A 1 76 ? -32.995 -47.836 -24.424 1.00 29.46 ? 76 PHE A N 1 ATOM 570 C CA . PHE A 1 76 ? -32.966 -46.886 -23.309 1.00 28.63 ? 76 PHE A CA 1 ATOM 571 C C . PHE A 1 76 ? -32.602 -45.470 -23.766 1.00 28.36 ? 76 PHE A C 1 ATOM 572 O O . PHE A 1 76 ? -31.541 -45.269 -24.347 1.00 27.95 ? 76 PHE A O 1 ATOM 573 C CB . PHE A 1 76 ? -31.969 -47.389 -22.235 1.00 29.11 ? 76 PHE A CB 1 ATOM 574 C CG . PHE A 1 76 ? -31.879 -46.496 -21.029 1.00 27.71 ? 76 PHE A CG 1 ATOM 575 C CD1 . PHE A 1 76 ? -33.017 -46.077 -20.378 1.00 27.06 ? 76 PHE A CD1 1 ATOM 576 C CD2 . PHE A 1 76 ? -30.640 -46.072 -20.556 1.00 28.21 ? 76 PHE A CD2 1 ATOM 577 C CE1 . PHE A 1 76 ? -32.921 -45.267 -19.264 1.00 28.44 ? 76 PHE A CE1 1 ATOM 578 C CE2 . PHE A 1 76 ? -30.547 -45.240 -19.460 1.00 24.65 ? 76 PHE A CE2 1 ATOM 579 C CZ . PHE A 1 76 ? -31.669 -44.869 -18.804 1.00 24.94 ? 76 PHE A CZ 1 ATOM 580 N N . HIS A 1 77 ? -33.471 -44.496 -23.487 1.00 27.89 ? 77 HIS A N 1 ATOM 581 C CA . HIS A 1 77 ? -33.241 -43.121 -23.920 1.00 28.91 ? 77 HIS A CA 1 ATOM 582 C C . HIS A 1 77 ? -31.944 -42.477 -23.316 1.00 29.29 ? 77 HIS A C 1 ATOM 583 O O . HIS A 1 77 ? -31.213 -41.718 -24.011 1.00 28.57 ? 77 HIS A O 1 ATOM 584 C CB . HIS A 1 77 ? -34.470 -42.261 -23.636 1.00 28.56 ? 77 HIS A CB 1 ATOM 585 C CG . HIS A 1 77 ? -34.344 -40.863 -24.151 1.00 30.32 ? 77 HIS A CG 1 ATOM 586 N ND1 . HIS A 1 77 ? -34.005 -40.580 -25.456 1.00 33.53 ? 77 HIS A ND1 1 ATOM 587 C CD2 . HIS A 1 77 ? -34.492 -39.666 -23.534 1.00 31.43 ? 77 HIS A CD2 1 ATOM 588 C CE1 . HIS A 1 77 ? -33.925 -39.270 -25.616 1.00 32.52 ? 77 HIS A CE1 1 ATOM 589 N NE2 . HIS A 1 77 ? -34.201 -38.696 -24.457 1.00 32.63 ? 77 HIS A NE2 1 ATOM 590 N N . GLY A 1 78 ? -31.679 -42.764 -22.039 1.00 28.13 ? 78 GLY A N 1 ATOM 591 C CA . GLY A 1 78 ? -30.505 -42.209 -21.350 1.00 27.54 ? 78 GLY A CA 1 ATOM 592 C C . GLY A 1 78 ? -29.203 -42.412 -22.094 1.00 27.47 ? 78 GLY A C 1 ATOM 593 O O . GLY A 1 78 ? -28.393 -41.508 -22.166 1.00 27.19 ? 78 GLY A O 1 ATOM 594 N N . SER A 1 79 ? -28.996 -43.581 -22.703 1.00 27.82 ? 79 SER A N 1 ATOM 595 C CA . SER A 1 79 ? -27.790 -43.820 -23.473 1.00 27.43 ? 79 SER A CA 1 ATOM 596 C C . SER A 1 79 ? -27.964 -43.551 -24.963 1.00 28.47 ? 79 SER A C 1 ATOM 597 O O . SER A 1 79 ? -27.101 -42.950 -25.622 1.00 27.60 ? 79 SER A O 1 ATOM 598 C CB . SER A 1 79 ? -27.327 -45.269 -23.277 1.00 28.86 ? 79 SER A CB 1 ATOM 599 O OG . SER A 1 79 ? -28.329 -46.175 -23.685 1.00 30.13 ? 79 SER A OG 1 ATOM 600 N N . GLU A 1 80 ? -29.091 -44.012 -25.511 1.00 27.76 ? 80 GLU A N 1 ATOM 601 C CA . GLU A 1 80 ? -29.288 -43.912 -26.945 1.00 27.67 ? 80 GLU A CA 1 ATOM 602 C C . GLU A 1 80 ? -29.422 -42.476 -27.413 1.00 25.95 ? 80 GLU A C 1 ATOM 603 O O . GLU A 1 80 ? -29.173 -42.188 -28.567 1.00 27.60 ? 80 GLU A O 1 ATOM 604 C CB . GLU A 1 80 ? -30.541 -44.715 -27.380 1.00 27.93 ? 80 GLU A CB 1 ATOM 605 C CG . GLU A 1 80 ? -30.494 -46.223 -27.120 1.00 29.73 ? 80 GLU A CG 1 ATOM 606 C CD . GLU A 1 80 ? -31.612 -46.968 -27.926 1.00 35.10 ? 80 GLU A CD 1 ATOM 607 O OE1 . GLU A 1 80 ? -31.341 -48.091 -28.390 1.00 34.62 ? 80 GLU A OE1 1 ATOM 608 O OE2 . GLU A 1 80 ? -32.728 -46.399 -28.101 1.00 30.85 ? 80 GLU A OE2 1 ATOM 609 N N . MET A 1 81 ? -29.858 -41.573 -26.554 1.00 24.66 ? 81 MET A N 1 ATOM 610 C CA . MET A 1 81 ? -29.861 -40.130 -26.912 1.00 23.56 ? 81 MET A CA 1 ATOM 611 C C . MET A 1 81 ? -28.522 -39.551 -27.380 1.00 22.88 ? 81 MET A C 1 ATOM 612 O O . MET A 1 81 ? -28.507 -38.512 -28.035 1.00 23.52 ? 81 MET A O 1 ATOM 613 C CB . MET A 1 81 ? -30.335 -39.263 -25.743 1.00 23.24 ? 81 MET A CB 1 ATOM 614 C CG . MET A 1 81 ? -29.391 -39.172 -24.564 1.00 23.94 ? 81 MET A CG 1 ATOM 615 S SD . MET A 1 81 ? -30.202 -38.139 -23.273 1.00 28.09 ? 81 MET A SD 1 ATOM 616 C CE . MET A 1 81 ? -29.780 -36.505 -23.941 1.00 17.52 ? 81 MET A CE 1 ATOM 617 N N . TRP A 1 82 ? -27.409 -40.179 -26.995 1.00 23.25 ? 82 TRP A N 1 ATOM 618 C CA . TRP A 1 82 ? -26.034 -39.772 -27.408 1.00 23.09 ? 82 TRP A CA 1 ATOM 619 C C . TRP A 1 82 ? -25.562 -40.430 -28.721 1.00 24.45 ? 82 TRP A C 1 ATOM 620 O O . TRP A 1 82 ? -24.556 -39.984 -29.356 1.00 24.76 ? 82 TRP A O 1 ATOM 621 C CB . TRP A 1 82 ? -25.071 -40.143 -26.261 1.00 22.27 ? 82 TRP A CB 1 ATOM 622 C CG . TRP A 1 82 ? -25.509 -39.481 -24.956 1.00 19.57 ? 82 TRP A CG 1 ATOM 623 C CD1 . TRP A 1 82 ? -26.063 -40.070 -23.861 1.00 22.22 ? 82 TRP A CD1 1 ATOM 624 C CD2 . TRP A 1 82 ? -25.471 -38.082 -24.680 1.00 21.57 ? 82 TRP A CD2 1 ATOM 625 N NE1 . TRP A 1 82 ? -26.364 -39.113 -22.878 1.00 19.10 ? 82 TRP A NE1 1 ATOM 626 C CE2 . TRP A 1 82 ? -26.012 -37.882 -23.377 1.00 22.22 ? 82 TRP A CE2 1 ATOM 627 C CE3 . TRP A 1 82 ? -25.045 -36.964 -25.419 1.00 21.94 ? 82 TRP A CE3 1 ATOM 628 C CZ2 . TRP A 1 82 ? -26.094 -36.607 -22.782 1.00 22.01 ? 82 TRP A CZ2 1 ATOM 629 C CZ3 . TRP A 1 82 ? -25.148 -35.697 -24.845 1.00 24.11 ? 82 TRP A CZ3 1 ATOM 630 C CH2 . TRP A 1 82 ? -25.659 -35.532 -23.524 1.00 23.03 ? 82 TRP A CH2 1 ATOM 631 N N . ASN A 1 83 ? -26.290 -41.469 -29.164 1.00 24.40 ? 83 ASN A N 1 ATOM 632 C CA . ASN A 1 83 ? -25.884 -42.186 -30.385 1.00 25.89 ? 83 ASN A CA 1 ATOM 633 C C . ASN A 1 83 ? -26.192 -41.358 -31.631 1.00 25.03 ? 83 ASN A C 1 ATOM 634 O O . ASN A 1 83 ? -27.115 -40.565 -31.638 1.00 24.21 ? 83 ASN A O 1 ATOM 635 C CB . ASN A 1 83 ? -26.593 -43.545 -30.461 1.00 26.16 ? 83 ASN A CB 1 ATOM 636 C CG . ASN A 1 83 ? -25.972 -44.588 -29.540 1.00 28.68 ? 83 ASN A CG 1 ATOM 637 O OD1 . ASN A 1 83 ? -24.765 -44.522 -29.230 1.00 32.60 ? 83 ASN A OD1 1 ATOM 638 N ND2 . ASN A 1 83 ? -26.791 -45.582 -29.105 1.00 24.19 ? 83 ASN A ND2 1 ATOM 639 N N . PRO A 1 84 ? -25.427 -41.538 -32.702 1.00 26.37 ? 84 PRO A N 1 ATOM 640 C CA . PRO A 1 84 ? -25.663 -40.725 -33.917 1.00 26.24 ? 84 PRO A CA 1 ATOM 641 C C . PRO A 1 84 ? -27.094 -40.855 -34.422 1.00 27.32 ? 84 PRO A C 1 ATOM 642 O O . PRO A 1 84 ? -27.683 -41.918 -34.271 1.00 27.37 ? 84 PRO A O 1 ATOM 643 C CB . PRO A 1 84 ? -24.727 -41.337 -34.939 1.00 27.11 ? 84 PRO A CB 1 ATOM 644 C CG . PRO A 1 84 ? -23.639 -42.062 -34.053 1.00 27.70 ? 84 PRO A CG 1 ATOM 645 C CD . PRO A 1 84 ? -24.388 -42.563 -32.876 1.00 26.52 ? 84 PRO A CD 1 ATOM 646 N N . ASN A 1 85 ? -27.655 -39.784 -35.004 1.00 26.76 ? 85 ASN A N 1 ATOM 647 C CA . ASN A 1 85 ? -28.967 -39.830 -35.594 1.00 26.66 ? 85 ASN A CA 1 ATOM 648 C C . ASN A 1 85 ? -28.960 -39.452 -37.088 1.00 27.16 ? 85 ASN A C 1 ATOM 649 O O . ASN A 1 85 ? -29.971 -39.080 -37.615 1.00 26.95 ? 85 ASN A O 1 ATOM 650 C CB . ASN A 1 85 ? -29.901 -38.875 -34.845 1.00 27.21 ? 85 ASN A CB 1 ATOM 651 C CG . ASN A 1 85 ? -29.405 -37.438 -34.880 1.00 26.90 ? 85 ASN A CG 1 ATOM 652 O OD1 . ASN A 1 85 ? -28.238 -37.186 -35.179 1.00 29.92 ? 85 ASN A OD1 1 ATOM 653 N ND2 . ASN A 1 85 ? -30.270 -36.497 -34.550 1.00 25.84 ? 85 ASN A ND2 1 ATOM 654 N N . THR A 1 86 ? -27.821 -39.504 -37.759 1.00 27.30 ? 86 THR A N 1 ATOM 655 C CA . THR A 1 86 ? -27.813 -39.509 -39.204 1.00 27.76 ? 86 THR A CA 1 ATOM 656 C C . THR A 1 86 ? -26.917 -40.659 -39.619 1.00 28.13 ? 86 THR A C 1 ATOM 657 O O . THR A 1 86 ? -26.126 -41.130 -38.804 1.00 27.86 ? 86 THR A O 1 ATOM 658 C CB . THR A 1 86 ? -27.298 -38.159 -39.827 1.00 27.83 ? 86 THR A CB 1 ATOM 659 O OG1 . THR A 1 86 ? -25.947 -37.957 -39.445 1.00 27.64 ? 86 THR A OG1 1 ATOM 660 C CG2 . THR A 1 86 ? -28.153 -36.964 -39.413 1.00 27.80 ? 86 THR A CG2 1 ATOM 661 N N . ASP A 1 87 ? -27.000 -41.103 -40.877 1.00 28.29 ? 87 ASP A N 1 ATOM 662 C CA . ASP A 1 87 ? -26.118 -42.171 -41.386 1.00 29.43 ? 87 ASP A CA 1 ATOM 663 C C . ASP A 1 87 ? -24.704 -41.848 -41.094 1.00 28.41 ? 87 ASP A C 1 ATOM 664 O O . ASP A 1 87 ? -24.348 -40.678 -41.219 1.00 27.99 ? 87 ASP A O 1 ATOM 665 C CB . ASP A 1 87 ? -26.159 -42.269 -42.932 1.00 29.46 ? 87 ASP A CB 1 ATOM 666 C CG . ASP A 1 87 ? -27.431 -42.807 -43.419 1.00 32.27 ? 87 ASP A CG 1 ATOM 667 O OD1 . ASP A 1 87 ? -27.502 -44.030 -43.634 1.00 35.35 ? 87 ASP A OD1 1 ATOM 668 O OD2 . ASP A 1 87 ? -28.379 -42.031 -43.511 1.00 33.77 ? 87 ASP A OD2 1 ATOM 669 N N . LEU A 1 88 ? -23.904 -42.892 -40.843 1.00 28.88 ? 88 LEU A N 1 ATOM 670 C CA . LEU A 1 88 ? -22.458 -42.803 -40.669 1.00 30.16 ? 88 LEU A CA 1 ATOM 671 C C . LEU A 1 88 ? -21.753 -42.831 -42.028 1.00 31.67 ? 88 LEU A C 1 ATOM 672 O O . LEU A 1 88 ? -22.137 -43.566 -42.948 1.00 33.38 ? 88 LEU A O 1 ATOM 673 C CB . LEU A 1 88 ? -21.922 -43.954 -39.816 1.00 29.61 ? 88 LEU A CB 1 ATOM 674 C CG . LEU A 1 88 ? -22.625 -44.166 -38.471 1.00 29.49 ? 88 LEU A CG 1 ATOM 675 C CD1 . LEU A 1 88 ? -21.821 -45.126 -37.618 1.00 26.79 ? 88 LEU A CD1 1 ATOM 676 C CD2 . LEU A 1 88 ? -22.842 -42.797 -37.736 1.00 28.29 ? 88 LEU A CD2 1 ATOM 677 N N . SER A 1 89 ? -20.695 -42.066 -42.182 1.00 31.29 ? 89 SER A N 1 ATOM 678 C CA . SER A 1 89 ? -20.031 -42.114 -43.446 1.00 30.81 ? 89 SER A CA 1 ATOM 679 C C . SER A 1 89 ? -18.741 -41.379 -43.281 1.00 30.43 ? 89 SER A C 1 ATOM 680 O O . SER A 1 89 ? -18.713 -40.437 -42.529 1.00 30.96 ? 89 SER A O 1 ATOM 681 C CB . SER A 1 89 ? -20.904 -41.418 -44.474 1.00 29.58 ? 89 SER A CB 1 ATOM 682 O OG . SER A 1 89 ? -20.083 -41.103 -45.587 1.00 32.21 ? 89 SER A OG 1 ATOM 683 N N . GLU A 1 90 ? -17.677 -41.800 -43.955 1.00 30.24 ? 90 GLU A N 1 ATOM 684 C CA . GLU A 1 90 ? -16.459 -40.999 -43.990 1.00 31.09 ? 90 GLU A CA 1 ATOM 685 C C . GLU A 1 90 ? -16.667 -39.634 -44.595 1.00 31.51 ? 90 GLU A C 1 ATOM 686 O O . GLU A 1 90 ? -15.844 -38.722 -44.412 1.00 30.33 ? 90 GLU A O 1 ATOM 687 C CB . GLU A 1 90 ? -15.384 -41.687 -44.780 1.00 30.38 ? 90 GLU A CB 1 ATOM 688 C CG . GLU A 1 90 ? -14.970 -42.968 -44.146 1.00 33.05 ? 90 GLU A CG 1 ATOM 689 C CD . GLU A 1 90 ? -13.763 -43.503 -44.806 1.00 35.83 ? 90 GLU A CD 1 ATOM 690 O OE1 . GLU A 1 90 ? -13.901 -44.348 -45.719 1.00 40.89 ? 90 GLU A OE1 1 ATOM 691 O OE2 . GLU A 1 90 ? -12.674 -43.038 -44.460 1.00 34.05 ? 90 GLU A OE2 1 ATOM 692 N N . ASP A 1 91 ? -17.752 -39.501 -45.358 1.00 31.99 ? 91 ASP A N 1 ATOM 693 C CA . ASP A 1 91 ? -18.075 -38.240 -45.954 1.00 32.41 ? 91 ASP A CA 1 ATOM 694 C C . ASP A 1 91 ? -18.975 -37.524 -44.920 1.00 31.95 ? 91 ASP A C 1 ATOM 695 O O . ASP A 1 91 ? -20.191 -37.641 -44.940 1.00 30.84 ? 91 ASP A O 1 ATOM 696 C CB . ASP A 1 91 ? -18.734 -38.459 -47.310 1.00 33.81 ? 91 ASP A CB 1 ATOM 697 C CG . ASP A 1 91 ? -19.235 -37.184 -47.900 1.00 39.93 ? 91 ASP A CG 1 ATOM 698 O OD1 . ASP A 1 91 ? -18.973 -36.114 -47.310 1.00 40.67 ? 91 ASP A OD1 1 ATOM 699 O OD2 . ASP A 1 91 ? -19.920 -37.250 -48.943 1.00 43.93 ? 91 ASP A OD2 1 ATOM 700 N N . CYS A 1 92 ? -18.349 -36.839 -43.944 1.00 30.46 ? 92 CYS A N 1 ATOM 701 C CA . CYS A 1 92 ? -19.107 -36.327 -42.804 1.00 28.88 ? 92 CYS A CA 1 ATOM 702 C C . CYS A 1 92 ? -18.656 -34.869 -42.467 1.00 29.47 ? 92 CYS A C 1 ATOM 703 O O . CYS A 1 92 ? -19.103 -34.278 -41.474 1.00 29.10 ? 92 CYS A O 1 ATOM 704 C CB . CYS A 1 92 ? -18.885 -37.269 -41.601 1.00 28.01 ? 92 CYS A CB 1 ATOM 705 S SG . CYS A 1 92 ? -17.098 -37.343 -41.118 1.00 27.74 ? 92 CYS A SG 1 ATOM 706 N N . LEU A 1 93 ? -17.758 -34.303 -43.276 1.00 28.34 ? 93 LEU A N 1 ATOM 707 C CA . LEU A 1 93 ? -17.239 -32.948 -42.989 1.00 28.17 ? 93 LEU A CA 1 ATOM 708 C C . LEU A 1 93 ? -18.163 -31.791 -43.385 1.00 27.60 ? 93 LEU A C 1 ATOM 709 O O . LEU A 1 93 ? -17.890 -31.050 -44.351 1.00 28.53 ? 93 LEU A O 1 ATOM 710 C CB . LEU A 1 93 ? -15.818 -32.771 -43.557 1.00 26.34 ? 93 LEU A CB 1 ATOM 711 C CG . LEU A 1 93 ? -14.823 -33.763 -42.974 1.00 26.80 ? 93 LEU A CG 1 ATOM 712 C CD1 . LEU A 1 93 ? -13.383 -33.503 -43.445 1.00 28.56 ? 93 LEU A CD1 1 ATOM 713 C CD2 . LEU A 1 93 ? -14.868 -33.796 -41.422 1.00 24.92 ? 93 LEU A CD2 1 ATOM 714 N N . TYR A 1 94 ? -19.221 -31.615 -42.595 1.00 26.97 ? 94 TYR A N 1 ATOM 715 C CA . TYR A 1 94 ? -20.237 -30.589 -42.767 1.00 26.83 ? 94 TYR A CA 1 ATOM 716 C C . TYR A 1 94 ? -20.450 -29.828 -41.453 1.00 27.46 ? 94 TYR A C 1 ATOM 717 O O . TYR A 1 94 ? -20.111 -30.318 -40.339 1.00 25.20 ? 94 TYR A O 1 ATOM 718 C CB . TYR A 1 94 ? -21.588 -31.211 -43.216 1.00 28.69 ? 94 TYR A CB 1 ATOM 719 C CG . TYR A 1 94 ? -21.427 -32.086 -44.477 1.00 29.83 ? 94 TYR A CG 1 ATOM 720 C CD1 . TYR A 1 94 ? -20.936 -33.387 -44.385 1.00 31.41 ? 94 TYR A CD1 1 ATOM 721 C CD2 . TYR A 1 94 ? -21.680 -31.572 -45.741 1.00 31.83 ? 94 TYR A CD2 1 ATOM 722 C CE1 . TYR A 1 94 ? -20.732 -34.158 -45.516 1.00 32.93 ? 94 TYR A CE1 1 ATOM 723 C CE2 . TYR A 1 94 ? -21.478 -32.336 -46.886 1.00 32.78 ? 94 TYR A CE2 1 ATOM 724 C CZ . TYR A 1 94 ? -21.003 -33.621 -46.766 1.00 35.14 ? 94 TYR A CZ 1 ATOM 725 O OH . TYR A 1 94 ? -20.775 -34.392 -47.897 1.00 40.15 ? 94 TYR A OH 1 ATOM 726 N N . LEU A 1 95 ? -21.070 -28.665 -41.593 1.00 26.30 ? 95 LEU A N 1 ATOM 727 C CA . LEU A 1 95 ? -21.408 -27.850 -40.456 1.00 27.17 ? 95 LEU A CA 1 ATOM 728 C C . LEU A 1 95 ? -22.822 -27.271 -40.614 1.00 27.84 ? 95 LEU A C 1 ATOM 729 O O . LEU A 1 95 ? -23.438 -27.384 -41.688 1.00 27.80 ? 95 LEU A O 1 ATOM 730 C CB . LEU A 1 95 ? -20.330 -26.774 -40.240 1.00 26.25 ? 95 LEU A CB 1 ATOM 731 C CG . LEU A 1 95 ? -20.038 -25.863 -41.423 1.00 22.91 ? 95 LEU A CG 1 ATOM 732 C CD1 . LEU A 1 95 ? -21.138 -24.842 -41.620 1.00 23.18 ? 95 LEU A CD1 1 ATOM 733 C CD2 . LEU A 1 95 ? -18.707 -25.185 -41.230 1.00 22.88 ? 95 LEU A CD2 1 ATOM 734 N N . ASN A 1 96 ? -23.340 -26.707 -39.529 1.00 26.56 ? 96 ASN A N 1 ATOM 735 C CA . ASN A 1 96 ? -24.689 -26.192 -39.451 1.00 26.77 ? 96 ASN A CA 1 ATOM 736 C C . ASN A 1 96 ? -24.600 -24.746 -38.951 1.00 26.93 ? 96 ASN A C 1 ATOM 737 O O . ASN A 1 96 ? -23.721 -24.406 -38.120 1.00 25.24 ? 96 ASN A O 1 ATOM 738 C CB . ASN A 1 96 ? -25.516 -27.006 -38.457 1.00 26.04 ? 96 ASN A CB 1 ATOM 739 C CG . ASN A 1 96 ? -25.420 -28.479 -38.703 1.00 30.67 ? 96 ASN A CG 1 ATOM 740 O OD1 . ASN A 1 96 ? -25.801 -28.975 -39.785 1.00 32.09 ? 96 ASN A OD1 1 ATOM 741 N ND2 . ASN A 1 96 ? -24.880 -29.210 -37.717 1.00 26.25 ? 96 ASN A ND2 1 ATOM 742 N N . VAL A 1 97 ? -25.481 -23.898 -39.485 1.00 26.81 ? 97 VAL A N 1 ATOM 743 C CA . VAL A 1 97 ? -25.563 -22.502 -39.116 1.00 26.40 ? 97 VAL A CA 1 ATOM 744 C C . VAL A 1 97 ? -27.018 -22.195 -38.782 1.00 27.37 ? 97 VAL A C 1 ATOM 745 O O . VAL A 1 97 ? -27.917 -22.582 -39.539 1.00 27.68 ? 97 VAL A O 1 ATOM 746 C CB . VAL A 1 97 ? -25.126 -21.587 -40.234 1.00 26.71 ? 97 VAL A CB 1 ATOM 747 C CG1 . VAL A 1 97 ? -25.210 -20.111 -39.726 1.00 28.11 ? 97 VAL A CG1 1 ATOM 748 C CG2 . VAL A 1 97 ? -23.718 -21.881 -40.663 1.00 24.23 ? 97 VAL A CG2 1 ATOM 749 N N . TRP A 1 98 ? -27.287 -21.546 -37.652 1.00 26.55 ? 98 TRP A N 1 ATOM 750 C CA . TRP A 1 98 ? -28.637 -21.113 -37.348 1.00 27.09 ? 98 TRP A CA 1 ATOM 751 C C . TRP A 1 98 ? -28.520 -19.623 -37.145 1.00 28.52 ? 98 TRP A C 1 ATOM 752 O O . TRP A 1 98 ? -27.627 -19.171 -36.425 1.00 29.22 ? 98 TRP A O 1 ATOM 753 C CB . TRP A 1 98 ? -29.145 -21.712 -36.053 1.00 26.45 ? 98 TRP A CB 1 ATOM 754 C CG . TRP A 1 98 ? -29.535 -23.169 -36.043 1.00 27.29 ? 98 TRP A CG 1 ATOM 755 C CD1 . TRP A 1 98 ? -30.796 -23.669 -36.285 1.00 27.32 ? 98 TRP A CD1 1 ATOM 756 C CD2 . TRP A 1 98 ? -28.711 -24.318 -35.696 1.00 24.76 ? 98 TRP A CD2 1 ATOM 757 N NE1 . TRP A 1 98 ? -30.785 -25.029 -36.149 1.00 27.48 ? 98 TRP A NE1 1 ATOM 758 C CE2 . TRP A 1 98 ? -29.534 -25.450 -35.771 1.00 25.98 ? 98 TRP A CE2 1 ATOM 759 C CE3 . TRP A 1 98 ? -27.365 -24.488 -35.349 1.00 24.78 ? 98 TRP A CE3 1 ATOM 760 C CZ2 . TRP A 1 98 ? -29.061 -26.738 -35.518 1.00 25.24 ? 98 TRP A CZ2 1 ATOM 761 C CZ3 . TRP A 1 98 ? -26.898 -25.758 -35.095 1.00 25.39 ? 98 TRP A CZ3 1 ATOM 762 C CH2 . TRP A 1 98 ? -27.743 -26.870 -35.173 1.00 21.46 ? 98 TRP A CH2 1 ATOM 763 N N . ILE A 1 99 ? -29.394 -18.856 -37.776 1.00 29.65 ? 99 ILE A N 1 ATOM 764 C CA . ILE A 1 99 ? -29.348 -17.440 -37.677 1.00 31.14 ? 99 ILE A CA 1 ATOM 765 C C . ILE A 1 99 ? -30.742 -16.927 -37.313 1.00 32.26 ? 99 ILE A C 1 ATOM 766 O O . ILE A 1 99 ? -31.768 -17.527 -37.679 1.00 33.52 ? 99 ILE A O 1 ATOM 767 C CB . ILE A 1 99 ? -28.747 -16.766 -38.940 1.00 32.10 ? 99 ILE A CB 1 ATOM 768 C CG1 . ILE A 1 99 ? -29.796 -16.603 -40.032 1.00 32.39 ? 99 ILE A CG1 1 ATOM 769 C CG2 . ILE A 1 99 ? -27.557 -17.572 -39.471 1.00 30.88 ? 99 ILE A CG2 1 ATOM 770 C CD1 . ILE A 1 99 ? -29.252 -15.917 -41.290 1.00 33.76 ? 99 ILE A CD1 1 ATOM 771 N N . PRO A 1 100 ? -30.793 -15.852 -36.520 1.00 32.21 ? 100 PRO A N 1 ATOM 772 C CA . PRO A 1 100 ? -32.074 -15.239 -36.203 1.00 33.90 ? 100 PRO A CA 1 ATOM 773 C C . PRO A 1 100 ? -32.745 -14.712 -37.492 1.00 34.43 ? 100 PRO A C 1 ATOM 774 O O . PRO A 1 100 ? -32.062 -14.470 -38.477 1.00 34.05 ? 100 PRO A O 1 ATOM 775 C CB . PRO A 1 100 ? -31.678 -14.036 -35.330 1.00 33.19 ? 100 PRO A CB 1 ATOM 776 C CG . PRO A 1 100 ? -30.251 -14.271 -34.990 1.00 33.81 ? 100 PRO A CG 1 ATOM 777 C CD . PRO A 1 100 ? -29.652 -15.078 -36.027 1.00 31.32 ? 100 PRO A CD 1 ATOM 778 N N . ALA A 1 101 ? -34.064 -14.524 -37.454 1.00 35.98 ? 101 ALA A N 1 ATOM 779 C CA . ALA A 1 101 ? -34.783 -13.843 -38.511 1.00 36.35 ? 101 ALA A CA 1 ATOM 780 C C . ALA A 1 101 ? -35.597 -12.750 -37.848 1.00 36.75 ? 101 ALA A C 1 ATOM 781 O O . ALA A 1 101 ? -36.244 -12.981 -36.861 1.00 37.48 ? 101 ALA A O 1 ATOM 782 C CB . ALA A 1 101 ? -35.678 -14.800 -39.225 1.00 36.01 ? 101 ALA A CB 1 ATOM 783 N N . PRO A 1 102 ? -35.555 -11.531 -38.387 1.00 37.63 ? 102 PRO A N 1 ATOM 784 C CA . PRO A 1 102 ? -34.765 -11.166 -39.571 1.00 37.11 ? 102 PRO A CA 1 ATOM 785 C C . PRO A 1 102 ? -33.254 -11.290 -39.359 1.00 38.36 ? 102 PRO A C 1 ATOM 786 O O . PRO A 1 102 ? -32.765 -11.182 -38.209 1.00 38.97 ? 102 PRO A O 1 ATOM 787 C CB . PRO A 1 102 ? -35.132 -9.697 -39.803 1.00 37.01 ? 102 PRO A CB 1 ATOM 788 C CG . PRO A 1 102 ? -35.717 -9.208 -38.482 1.00 37.94 ? 102 PRO A CG 1 ATOM 789 C CD . PRO A 1 102 ? -36.355 -10.411 -37.842 1.00 37.11 ? 102 PRO A CD 1 ATOM 790 N N . LYS A 1 103 ? -32.548 -11.491 -40.480 1.00 38.06 ? 103 LYS A N 1 ATOM 791 C CA . LYS A 1 103 ? -31.127 -11.636 -40.565 1.00 37.95 ? 103 LYS A CA 1 ATOM 792 C C . LYS A 1 103 ? -30.492 -10.563 -39.732 1.00 38.58 ? 103 LYS A C 1 ATOM 793 O O . LYS A 1 103 ? -30.852 -9.400 -39.867 1.00 39.17 ? 103 LYS A O 1 ATOM 794 C CB . LYS A 1 103 ? -30.692 -11.437 -42.005 1.00 38.04 ? 103 LYS A CB 1 ATOM 795 C CG . LYS A 1 103 ? -29.295 -11.870 -42.295 1.00 38.67 ? 103 LYS A CG 1 ATOM 796 C CD . LYS A 1 103 ? -28.947 -11.468 -43.717 1.00 43.35 ? 103 LYS A CD 1 ATOM 797 C CE . LYS A 1 103 ? -27.603 -12.023 -44.176 1.00 46.44 ? 103 LYS A CE 1 ATOM 798 N NZ . LYS A 1 103 ? -26.817 -10.923 -44.841 1.00 48.06 ? 103 LYS A NZ 1 ATOM 799 N N . PRO A 1 104 ? -29.536 -10.945 -38.868 1.00 37.46 ? 104 PRO A N 1 ATOM 800 C CA . PRO A 1 104 ? -28.908 -9.969 -37.992 1.00 37.23 ? 104 PRO A CA 1 ATOM 801 C C . PRO A 1 104 ? -27.936 -9.118 -38.765 1.00 37.68 ? 104 PRO A C 1 ATOM 802 O O . PRO A 1 104 ? -27.575 -9.474 -39.898 1.00 37.59 ? 104 PRO A O 1 ATOM 803 C CB . PRO A 1 104 ? -28.177 -10.844 -36.960 1.00 36.30 ? 104 PRO A CB 1 ATOM 804 C CG . PRO A 1 104 ? -27.882 -12.111 -37.716 1.00 36.98 ? 104 PRO A CG 1 ATOM 805 C CD . PRO A 1 104 ? -29.084 -12.325 -38.598 1.00 36.65 ? 104 PRO A CD 1 ATOM 806 N N . LYS A 1 105 ? -27.491 -8.010 -38.163 1.00 38.07 ? 105 LYS A N 1 ATOM 807 C CA . LYS A 1 105 ? -26.517 -7.159 -38.823 1.00 39.29 ? 105 LYS A CA 1 ATOM 808 C C . LYS A 1 105 ? -25.045 -7.559 -38.588 1.00 40.17 ? 105 LYS A C 1 ATOM 809 O O . LYS A 1 105 ? -24.214 -7.516 -39.529 1.00 42.07 ? 105 LYS A O 1 ATOM 810 C CB . LYS A 1 105 ? -26.769 -5.670 -38.493 1.00 40.22 ? 105 LYS A CB 1 ATOM 811 C CG . LYS A 1 105 ? -28.004 -5.070 -39.225 1.00 39.66 ? 105 LYS A CG 1 ATOM 812 C CD . LYS A 1 105 ? -27.658 -4.206 -40.454 1.00 41.01 ? 105 LYS A CD 1 ATOM 813 C CE . LYS A 1 105 ? -28.995 -3.734 -41.159 1.00 40.39 ? 105 LYS A CE 1 ATOM 814 N NZ . LYS A 1 105 ? -30.097 -3.961 -40.139 1.00 41.26 ? 105 LYS A NZ 1 ATOM 815 N N . ASN A 1 106 ? -24.696 -7.935 -37.360 1.00 38.28 ? 106 ASN A N 1 ATOM 816 C CA . ASN A 1 106 ? -23.303 -8.201 -37.030 1.00 36.97 ? 106 ASN A CA 1 ATOM 817 C C . ASN A 1 106 ? -23.362 -9.005 -35.710 1.00 34.54 ? 106 ASN A C 1 ATOM 818 O O . ASN A 1 106 ? -22.940 -8.554 -34.656 1.00 34.11 ? 106 ASN A O 1 ATOM 819 C CB . ASN A 1 106 ? -22.603 -6.856 -36.857 1.00 37.71 ? 106 ASN A CB 1 ATOM 820 C CG . ASN A 1 106 ? -21.120 -6.929 -37.055 1.00 42.89 ? 106 ASN A CG 1 ATOM 821 O OD1 . ASN A 1 106 ? -20.636 -7.631 -37.953 1.00 44.78 ? 106 ASN A OD1 1 ATOM 822 N ND2 . ASN A 1 106 ? -20.364 -6.201 -36.186 1.00 49.72 ? 106 ASN A ND2 1 ATOM 823 N N . ALA A 1 107 ? -23.991 -10.166 -35.775 1.00 32.22 ? 107 ALA A N 1 ATOM 824 C CA . ALA A 1 107 ? -24.328 -10.942 -34.596 1.00 30.02 ? 107 ALA A CA 1 ATOM 825 C C . ALA A 1 107 ? -23.108 -11.634 -34.042 1.00 29.31 ? 107 ALA A C 1 ATOM 826 O O . ALA A 1 107 ? -22.176 -12.039 -34.787 1.00 29.17 ? 107 ALA A O 1 ATOM 827 C CB . ALA A 1 107 ? -25.383 -11.962 -34.937 1.00 30.83 ? 107 ALA A CB 1 ATOM 828 N N . THR A 1 108 ? -23.089 -11.770 -32.726 1.00 28.15 ? 108 THR A N 1 ATOM 829 C CA . THR A 1 108 ? -22.089 -12.623 -32.115 1.00 27.10 ? 108 THR A CA 1 ATOM 830 C C . THR A 1 108 ? -22.300 -14.105 -32.507 1.00 26.32 ? 108 THR A C 1 ATOM 831 O O . THR A 1 108 ? -23.440 -14.603 -32.557 1.00 26.31 ? 108 THR A O 1 ATOM 832 C CB . THR A 1 108 ? -22.062 -12.408 -30.623 1.00 28.37 ? 108 THR A CB 1 ATOM 833 O OG1 . THR A 1 108 ? -21.217 -11.279 -30.347 1.00 28.94 ? 108 THR A OG1 1 ATOM 834 C CG2 . THR A 1 108 ? -21.519 -13.670 -29.881 1.00 27.13 ? 108 THR A CG2 1 ATOM 835 N N . VAL A 1 109 ? -21.191 -14.801 -32.782 1.00 26.07 ? 109 VAL A N 1 ATOM 836 C CA . VAL A 1 109 ? -21.216 -16.216 -33.150 1.00 25.00 ? 109 VAL A CA 1 ATOM 837 C C . VAL A 1 109 ? -20.753 -17.187 -32.010 1.00 25.01 ? 109 VAL A C 1 ATOM 838 O O . VAL A 1 109 ? -19.685 -17.032 -31.413 1.00 24.28 ? 109 VAL A O 1 ATOM 839 C CB . VAL A 1 109 ? -20.357 -16.461 -34.402 1.00 25.24 ? 109 VAL A CB 1 ATOM 840 C CG1 . VAL A 1 109 ? -20.507 -17.898 -34.880 1.00 23.84 ? 109 VAL A CG1 1 ATOM 841 C CG2 . VAL A 1 109 ? -20.744 -15.469 -35.544 1.00 24.79 ? 109 VAL A CG2 1 ATOM 842 N N . LEU A 1 110 ? -21.578 -18.201 -31.764 1.00 24.71 ? 110 LEU A N 1 ATOM 843 C CA . LEU A 1 110 ? -21.308 -19.322 -30.862 1.00 24.46 ? 110 LEU A CA 1 ATOM 844 C C . LEU A 1 110 ? -21.016 -20.607 -31.688 1.00 24.53 ? 110 LEU A C 1 ATOM 845 O O . LEU A 1 110 ? -21.864 -21.092 -32.443 1.00 23.39 ? 110 LEU A O 1 ATOM 846 C CB . LEU A 1 110 ? -22.510 -19.501 -29.909 1.00 24.45 ? 110 LEU A CB 1 ATOM 847 C CG . LEU A 1 110 ? -22.524 -18.598 -28.676 1.00 28.78 ? 110 LEU A CG 1 ATOM 848 C CD1 . LEU A 1 110 ? -23.812 -18.830 -27.896 1.00 30.39 ? 110 LEU A CD1 1 ATOM 849 C CD2 . LEU A 1 110 ? -21.405 -19.116 -27.808 1.00 33.76 ? 110 LEU A CD2 1 ATOM 850 N N . ILE A 1 111 ? -19.791 -21.148 -31.573 1.00 23.55 ? 111 ILE A N 1 ATOM 851 C CA . ILE A 1 111 ? -19.472 -22.376 -32.256 1.00 21.89 ? 111 ILE A CA 1 ATOM 852 C C . ILE A 1 111 ? -19.331 -23.540 -31.322 1.00 21.87 ? 111 ILE A C 1 ATOM 853 O O . ILE A 1 111 ? -18.407 -23.561 -30.456 1.00 21.87 ? 111 ILE A O 1 ATOM 854 C CB . ILE A 1 111 ? -18.167 -22.228 -33.012 1.00 22.30 ? 111 ILE A CB 1 ATOM 855 C CG1 . ILE A 1 111 ? -18.215 -20.974 -33.908 1.00 20.41 ? 111 ILE A CG1 1 ATOM 856 C CG2 . ILE A 1 111 ? -17.900 -23.487 -33.774 1.00 21.37 ? 111 ILE A CG2 1 ATOM 857 C CD1 . ILE A 1 111 ? -16.982 -20.859 -34.869 1.00 25.19 ? 111 ILE A CD1 1 ATOM 858 N N . TRP A 1 112 ? -20.219 -24.519 -31.485 1.00 20.39 ? 112 TRP A N 1 ATOM 859 C CA . TRP A 1 112 ? -20.270 -25.709 -30.599 1.00 21.08 ? 112 TRP A CA 1 ATOM 860 C C . TRP A 1 112 ? -19.385 -26.849 -31.064 1.00 21.09 ? 112 TRP A C 1 ATOM 861 O O . TRP A 1 112 ? -19.414 -27.216 -32.262 1.00 20.48 ? 112 TRP A O 1 ATOM 862 C CB . TRP A 1 112 ? -21.704 -26.195 -30.476 1.00 21.18 ? 112 TRP A CB 1 ATOM 863 C CG . TRP A 1 112 ? -21.876 -27.471 -29.699 1.00 22.52 ? 112 TRP A CG 1 ATOM 864 C CD1 . TRP A 1 112 ? -22.167 -28.715 -30.194 1.00 19.79 ? 112 TRP A CD1 1 ATOM 865 C CD2 . TRP A 1 112 ? -21.797 -27.616 -28.259 1.00 23.02 ? 112 TRP A CD2 1 ATOM 866 N NE1 . TRP A 1 112 ? -22.246 -29.617 -29.152 1.00 18.21 ? 112 TRP A NE1 1 ATOM 867 C CE2 . TRP A 1 112 ? -22.027 -28.970 -27.962 1.00 21.94 ? 112 TRP A CE2 1 ATOM 868 C CE3 . TRP A 1 112 ? -21.552 -26.722 -27.209 1.00 19.15 ? 112 TRP A CE3 1 ATOM 869 C CZ2 . TRP A 1 112 ? -22.065 -29.452 -26.642 1.00 20.26 ? 112 TRP A CZ2 1 ATOM 870 C CZ3 . TRP A 1 112 ? -21.599 -27.170 -25.935 1.00 19.83 ? 112 TRP A CZ3 1 ATOM 871 C CH2 . TRP A 1 112 ? -21.850 -28.531 -25.643 1.00 21.71 ? 112 TRP A CH2 1 ATOM 872 N N . ILE A 1 113 ? -18.575 -27.391 -30.149 1.00 20.42 ? 113 ILE A N 1 ATOM 873 C CA . ILE A 1 113 ? -17.778 -28.552 -30.455 1.00 19.81 ? 113 ILE A CA 1 ATOM 874 C C . ILE A 1 113 ? -18.216 -29.704 -29.580 1.00 21.44 ? 113 ILE A C 1 ATOM 875 O O . ILE A 1 113 ? -18.096 -29.613 -28.369 1.00 20.33 ? 113 ILE A O 1 ATOM 876 C CB . ILE A 1 113 ? -16.256 -28.305 -30.278 1.00 20.08 ? 113 ILE A CB 1 ATOM 877 C CG1 . ILE A 1 113 ? -15.828 -27.051 -31.092 1.00 18.67 ? 113 ILE A CG1 1 ATOM 878 C CG2 . ILE A 1 113 ? -15.509 -29.597 -30.693 1.00 17.67 ? 113 ILE A CG2 1 ATOM 879 C CD1 . ILE A 1 113 ? -14.392 -26.588 -30.956 1.00 16.46 ? 113 ILE A CD1 1 ATOM 880 N N . TYR A 1 114 ? -18.782 -30.775 -30.173 1.00 21.74 ? 114 TYR A N 1 ATOM 881 C CA . TYR A 1 114 ? -19.372 -31.873 -29.342 1.00 20.37 ? 114 TYR A CA 1 ATOM 882 C C . TYR A 1 114 ? -18.316 -32.698 -28.671 1.00 19.27 ? 114 TYR A C 1 ATOM 883 O O . TYR A 1 114 ? -17.166 -32.817 -29.177 1.00 19.33 ? 114 TYR A O 1 ATOM 884 C CB . TYR A 1 114 ? -20.327 -32.795 -30.152 1.00 20.40 ? 114 TYR A CB 1 ATOM 885 C CG . TYR A 1 114 ? -19.737 -33.408 -31.398 1.00 21.21 ? 114 TYR A CG 1 ATOM 886 C CD1 . TYR A 1 114 ? -18.813 -34.460 -31.327 1.00 23.41 ? 114 TYR A CD1 1 ATOM 887 C CD2 . TYR A 1 114 ? -20.137 -32.978 -32.661 1.00 20.02 ? 114 TYR A CD2 1 ATOM 888 C CE1 . TYR A 1 114 ? -18.271 -35.016 -32.485 1.00 22.56 ? 114 TYR A CE1 1 ATOM 889 C CE2 . TYR A 1 114 ? -19.589 -33.501 -33.797 1.00 20.21 ? 114 TYR A CE2 1 ATOM 890 C CZ . TYR A 1 114 ? -18.679 -34.516 -33.722 1.00 23.32 ? 114 TYR A CZ 1 ATOM 891 O OH . TYR A 1 114 ? -18.163 -35.021 -34.900 1.00 24.21 ? 114 TYR A OH 1 ATOM 892 N N . GLY A 1 115 ? -18.699 -33.271 -27.522 1.00 19.26 ? 115 GLY A N 1 ATOM 893 C CA . GLY A 1 115 ? -17.947 -34.318 -26.921 1.00 18.47 ? 115 GLY A CA 1 ATOM 894 C C . GLY A 1 115 ? -18.333 -35.753 -27.417 1.00 20.85 ? 115 GLY A C 1 ATOM 895 O O . GLY A 1 115 ? -19.061 -35.940 -28.415 1.00 20.38 ? 115 GLY A O 1 ATOM 896 N N . GLY A 1 116 ? -17.774 -36.745 -26.740 1.00 19.44 ? 116 GLY A N 1 ATOM 897 C CA . GLY A 1 116 ? -17.880 -38.125 -27.084 1.00 22.21 ? 116 GLY A CA 1 ATOM 898 C C . GLY A 1 116 ? -16.516 -38.814 -26.989 1.00 23.37 ? 116 GLY A C 1 ATOM 899 O O . GLY A 1 116 ? -16.237 -39.775 -27.737 1.00 23.20 ? 116 GLY A O 1 ATOM 900 N N . GLY A 1 117 ? -15.620 -38.305 -26.135 1.00 22.18 ? 117 GLY A N 1 ATOM 901 C CA . GLY A 1 117 ? -14.371 -39.078 -25.844 1.00 21.71 ? 117 GLY A CA 1 ATOM 902 C C . GLY A 1 117 ? -13.362 -39.060 -26.986 1.00 21.69 ? 117 GLY A C 1 ATOM 903 O O . GLY A 1 117 ? -12.393 -39.814 -26.968 1.00 22.75 ? 117 GLY A O 1 ATOM 904 N N . PHE A 1 118 ? -13.603 -38.188 -27.969 1.00 21.24 ? 118 PHE A N 1 ATOM 905 C CA . PHE A 1 118 ? -12.885 -38.155 -29.258 1.00 22.47 ? 118 PHE A CA 1 ATOM 906 C C . PHE A 1 118 ? -13.131 -39.436 -30.113 1.00 23.36 ? 118 PHE A C 1 ATOM 907 O O . PHE A 1 118 ? -12.441 -39.636 -31.112 1.00 22.32 ? 118 PHE A O 1 ATOM 908 C CB . PHE A 1 118 ? -11.367 -37.933 -29.096 1.00 22.45 ? 118 PHE A CB 1 ATOM 909 C CG . PHE A 1 118 ? -10.987 -36.574 -28.493 1.00 21.59 ? 118 PHE A CG 1 ATOM 910 C CD1 . PHE A 1 118 ? -11.041 -35.405 -29.263 1.00 18.26 ? 118 PHE A CD1 1 ATOM 911 C CD2 . PHE A 1 118 ? -10.559 -36.495 -27.155 1.00 19.81 ? 118 PHE A CD2 1 ATOM 912 C CE1 . PHE A 1 118 ? -10.705 -34.180 -28.736 1.00 21.15 ? 118 PHE A CE1 1 ATOM 913 C CE2 . PHE A 1 118 ? -10.185 -35.256 -26.598 1.00 19.92 ? 118 PHE A CE2 1 ATOM 914 C CZ . PHE A 1 118 ? -10.269 -34.088 -27.379 1.00 16.37 ? 118 PHE A CZ 1 ATOM 915 N N . GLN A 1 119 ? -14.090 -40.289 -29.712 1.00 23.49 ? 119 GLN A N 1 ATOM 916 C CA . GLN A 1 119 ? -14.273 -41.595 -30.361 1.00 23.63 ? 119 GLN A CA 1 ATOM 917 C C . GLN A 1 119 ? -15.645 -41.603 -31.005 1.00 24.42 ? 119 GLN A C 1 ATOM 918 O O . GLN A 1 119 ? -15.889 -42.387 -31.919 1.00 25.34 ? 119 GLN A O 1 ATOM 919 C CB . GLN A 1 119 ? -14.220 -42.797 -29.362 1.00 24.03 ? 119 GLN A CB 1 ATOM 920 C CG . GLN A 1 119 ? -12.973 -42.964 -28.491 1.00 22.95 ? 119 GLN A CG 1 ATOM 921 C CD . GLN A 1 119 ? -11.712 -42.675 -29.248 1.00 28.12 ? 119 GLN A CD 1 ATOM 922 O OE1 . GLN A 1 119 ? -11.340 -43.413 -30.151 1.00 30.63 ? 119 GLN A OE1 1 ATOM 923 N NE2 . GLN A 1 119 ? -11.075 -41.557 -28.934 1.00 29.54 ? 119 GLN A NE2 1 ATOM 924 N N . THR A 1 120 ? -16.523 -40.727 -30.514 1.00 23.47 ? 120 THR A N 1 ATOM 925 C CA . THR A 1 120 ? -17.886 -40.624 -30.926 1.00 23.15 ? 120 THR A CA 1 ATOM 926 C C . THR A 1 120 ? -18.408 -39.169 -30.925 1.00 23.25 ? 120 THR A C 1 ATOM 927 O O . THR A 1 120 ? -17.759 -38.279 -30.367 1.00 23.60 ? 120 THR A O 1 ATOM 928 C CB . THR A 1 120 ? -18.786 -41.413 -29.927 1.00 24.65 ? 120 THR A CB 1 ATOM 929 O OG1 . THR A 1 120 ? -18.720 -40.774 -28.638 1.00 23.39 ? 120 THR A OG1 1 ATOM 930 C CG2 . THR A 1 120 ? -18.343 -42.900 -29.830 1.00 21.06 ? 120 THR A CG2 1 ATOM 931 N N . GLY A 1 121 ? -19.573 -38.949 -31.536 1.00 21.23 ? 121 GLY A N 1 ATOM 932 C CA . GLY A 1 121 ? -20.404 -37.788 -31.313 1.00 21.95 ? 121 GLY A CA 1 ATOM 933 C C . GLY A 1 121 ? -20.853 -37.236 -32.645 1.00 21.81 ? 121 GLY A C 1 ATOM 934 O O . GLY A 1 121 ? -20.330 -37.616 -33.671 1.00 21.72 ? 121 GLY A O 1 ATOM 935 N N . THR A 1 122 ? -21.819 -36.342 -32.633 1.00 21.96 ? 122 THR A N 1 ATOM 936 C CA . THR A 1 122 ? -22.231 -35.727 -33.880 1.00 24.04 ? 122 THR A CA 1 ATOM 937 C C . THR A 1 122 ? -22.909 -34.413 -33.554 1.00 23.61 ? 122 THR A C 1 ATOM 938 O O . THR A 1 122 ? -23.455 -34.287 -32.450 1.00 23.67 ? 122 THR A O 1 ATOM 939 C CB . THR A 1 122 ? -23.151 -36.670 -34.736 1.00 24.41 ? 122 THR A CB 1 ATOM 940 O OG1 . THR A 1 122 ? -23.475 -36.026 -35.971 1.00 25.08 ? 122 THR A OG1 1 ATOM 941 C CG2 . THR A 1 122 ? -24.434 -37.006 -34.001 1.00 25.56 ? 122 THR A CG2 1 ATOM 942 N N . SER A 1 123 ? -22.844 -33.431 -34.464 1.00 22.71 ? 123 SER A N 1 ATOM 943 C CA . SER A 1 123 ? -23.524 -32.170 -34.251 1.00 23.77 ? 123 SER A CA 1 ATOM 944 C C . SER A 1 123 ? -25.033 -32.158 -34.408 1.00 24.72 ? 123 SER A C 1 ATOM 945 O O . SER A 1 123 ? -25.714 -31.154 -34.043 1.00 24.79 ? 123 SER A O 1 ATOM 946 C CB . SER A 1 123 ? -22.902 -31.052 -35.073 1.00 24.72 ? 123 SER A CB 1 ATOM 947 O OG . SER A 1 123 ? -23.014 -31.290 -36.459 1.00 26.25 ? 123 SER A OG 1 ATOM 948 N N . SER A 1 124 ? -25.600 -33.247 -34.916 1.00 25.37 ? 124 SER A N 1 ATOM 949 C CA . SER A 1 124 ? -27.041 -33.242 -35.200 1.00 25.73 ? 124 SER A CA 1 ATOM 950 C C . SER A 1 124 ? -27.892 -33.693 -34.016 1.00 26.49 ? 124 SER A C 1 ATOM 951 O O . SER A 1 124 ? -29.103 -33.777 -34.100 1.00 27.21 ? 124 SER A O 1 ATOM 952 C CB . SER A 1 124 ? -27.370 -34.101 -36.429 1.00 26.17 ? 124 SER A CB 1 ATOM 953 O OG . SER A 1 124 ? -26.608 -35.295 -36.443 1.00 25.67 ? 124 SER A OG 1 ATOM 954 N N . LEU A 1 125 ? -27.282 -34.037 -32.908 1.00 25.41 ? 125 LEU A N 1 ATOM 955 C CA . LEU A 1 125 ? -28.096 -34.406 -31.765 1.00 23.78 ? 125 LEU A CA 1 ATOM 956 C C . LEU A 1 125 ? -29.075 -33.307 -31.371 1.00 24.86 ? 125 LEU A C 1 ATOM 957 O O . LEU A 1 125 ? -28.855 -32.073 -31.563 1.00 24.32 ? 125 LEU A O 1 ATOM 958 C CB . LEU A 1 125 ? -27.229 -34.754 -30.545 1.00 22.51 ? 125 LEU A CB 1 ATOM 959 C CG . LEU A 1 125 ? -26.182 -35.841 -30.632 1.00 21.85 ? 125 LEU A CG 1 ATOM 960 C CD1 . LEU A 1 125 ? -25.779 -36.271 -29.186 1.00 14.55 ? 125 LEU A CD1 1 ATOM 961 C CD2 . LEU A 1 125 ? -26.730 -37.045 -31.433 1.00 23.99 ? 125 LEU A CD2 1 ATOM 962 N N . HIS A 1 126 ? -30.169 -33.769 -30.781 1.00 24.62 ? 126 HIS A N 1 ATOM 963 C CA . HIS A 1 126 ? -31.275 -32.917 -30.447 1.00 25.88 ? 126 HIS A CA 1 ATOM 964 C C . HIS A 1 126 ? -30.857 -31.934 -29.312 1.00 25.61 ? 126 HIS A C 1 ATOM 965 O O . HIS A 1 126 ? -31.369 -30.810 -29.219 1.00 24.75 ? 126 HIS A O 1 ATOM 966 C CB . HIS A 1 126 ? -32.434 -33.851 -30.003 1.00 27.08 ? 126 HIS A CB 1 ATOM 967 C CG . HIS A 1 126 ? -33.576 -33.142 -29.353 1.00 34.27 ? 126 HIS A CG 1 ATOM 968 N ND1 . HIS A 1 126 ? -34.310 -32.160 -30.000 1.00 40.75 ? 126 HIS A ND1 1 ATOM 969 C CD2 . HIS A 1 126 ? -34.113 -33.263 -28.108 1.00 38.34 ? 126 HIS A CD2 1 ATOM 970 C CE1 . HIS A 1 126 ? -35.233 -31.692 -29.171 1.00 43.03 ? 126 HIS A CE1 1 ATOM 971 N NE2 . HIS A 1 126 ? -35.150 -32.361 -28.027 1.00 41.66 ? 126 HIS A NE2 1 ATOM 972 N N . VAL A 1 127 ? -29.977 -32.383 -28.407 1.00 25.60 ? 127 VAL A N 1 ATOM 973 C CA . VAL A 1 127 ? -29.577 -31.516 -27.286 1.00 25.32 ? 127 VAL A CA 1 ATOM 974 C C . VAL A 1 127 ? -28.592 -30.437 -27.736 1.00 25.41 ? 127 VAL A C 1 ATOM 975 O O . VAL A 1 127 ? -28.337 -29.504 -26.979 1.00 25.98 ? 127 VAL A O 1 ATOM 976 C CB . VAL A 1 127 ? -29.073 -32.314 -26.043 1.00 26.14 ? 127 VAL A CB 1 ATOM 977 C CG1 . VAL A 1 127 ? -30.249 -33.091 -25.436 1.00 26.39 ? 127 VAL A CG1 1 ATOM 978 C CG2 . VAL A 1 127 ? -27.939 -33.249 -26.384 1.00 24.14 ? 127 VAL A CG2 1 ATOM 979 N N . TYR A 1 128 ? -28.055 -30.560 -28.967 1.00 23.69 ? 128 TYR A N 1 ATOM 980 C CA . TYR A 1 128 ? -27.181 -29.550 -29.567 1.00 22.32 ? 128 TYR A CA 1 ATOM 981 C C . TYR A 1 128 ? -27.903 -28.653 -30.607 1.00 22.71 ? 128 TYR A C 1 ATOM 982 O O . TYR A 1 128 ? -27.289 -27.918 -31.379 1.00 22.59 ? 128 TYR A O 1 ATOM 983 C CB . TYR A 1 128 ? -25.955 -30.167 -30.243 1.00 20.98 ? 128 TYR A CB 1 ATOM 984 C CG . TYR A 1 128 ? -25.170 -31.238 -29.465 1.00 18.47 ? 128 TYR A CG 1 ATOM 985 C CD1 . TYR A 1 128 ? -25.072 -31.228 -28.051 1.00 16.71 ? 128 TYR A CD1 1 ATOM 986 C CD2 . TYR A 1 128 ? -24.455 -32.211 -30.145 1.00 15.49 ? 128 TYR A CD2 1 ATOM 987 C CE1 . TYR A 1 128 ? -24.334 -32.273 -27.359 1.00 14.20 ? 128 TYR A CE1 1 ATOM 988 C CE2 . TYR A 1 128 ? -23.682 -33.201 -29.481 1.00 11.54 ? 128 TYR A CE2 1 ATOM 989 C CZ . TYR A 1 128 ? -23.650 -33.204 -28.068 1.00 16.52 ? 128 TYR A CZ 1 ATOM 990 O OH . TYR A 1 128 ? -22.905 -34.146 -27.415 1.00 18.74 ? 128 TYR A OH 1 ATOM 991 N N . ASP A 1 129 ? -29.210 -28.711 -30.643 1.00 24.35 ? 129 ASP A N 1 ATOM 992 C CA . ASP A 1 129 ? -29.946 -27.916 -31.647 1.00 24.71 ? 129 ASP A CA 1 ATOM 993 C C . ASP A 1 129 ? -29.891 -26.423 -31.333 1.00 24.57 ? 129 ASP A C 1 ATOM 994 O O . ASP A 1 129 ? -30.485 -25.979 -30.364 1.00 23.81 ? 129 ASP A O 1 ATOM 995 C CB . ASP A 1 129 ? -31.406 -28.334 -31.558 1.00 26.51 ? 129 ASP A CB 1 ATOM 996 C CG . ASP A 1 129 ? -32.256 -27.819 -32.750 1.00 28.64 ? 129 ASP A CG 1 ATOM 997 O OD1 . ASP A 1 129 ? -31.865 -26.821 -33.413 1.00 29.83 ? 129 ASP A OD1 1 ATOM 998 O OD2 . ASP A 1 129 ? -33.310 -28.440 -32.975 1.00 31.90 ? 129 ASP A OD2 1 ATOM 999 N N . GLY A 1 130 ? -29.254 -25.614 -32.171 1.00 24.62 ? 130 GLY A N 1 ATOM 1000 C CA . GLY A 1 130 ? -29.070 -24.229 -31.796 1.00 24.95 ? 130 GLY A CA 1 ATOM 1001 C C . GLY A 1 130 ? -30.117 -23.215 -32.213 1.00 27.25 ? 130 GLY A C 1 ATOM 1002 O O . GLY A 1 130 ? -29.870 -22.015 -32.164 1.00 26.60 ? 130 GLY A O 1 ATOM 1003 N N . LYS A 1 131 ? -31.304 -23.673 -32.586 1.00 28.19 ? 131 LYS A N 1 ATOM 1004 C CA . LYS A 1 131 ? -32.396 -22.741 -32.935 1.00 28.82 ? 131 LYS A CA 1 ATOM 1005 C C . LYS A 1 131 ? -32.977 -21.992 -31.742 1.00 28.72 ? 131 LYS A C 1 ATOM 1006 O O . LYS A 1 131 ? -33.409 -20.847 -31.884 1.00 28.59 ? 131 LYS A O 1 ATOM 1007 C CB . LYS A 1 131 ? -33.542 -23.494 -33.657 1.00 29.43 ? 131 LYS A CB 1 ATOM 1008 C CG . LYS A 1 131 ? -34.293 -24.364 -32.758 1.00 29.30 ? 131 LYS A CG 1 ATOM 1009 C CD . LYS A 1 131 ? -35.351 -25.115 -33.531 1.00 35.81 ? 131 LYS A CD 1 ATOM 1010 C CE . LYS A 1 131 ? -36.282 -25.881 -32.598 1.00 34.44 ? 131 LYS A CE 1 ATOM 1011 N NZ . LYS A 1 131 ? -36.751 -27.029 -33.382 1.00 37.35 ? 131 LYS A NZ 1 ATOM 1012 N N . PHE A 1 132 ? -32.998 -22.595 -30.558 1.00 28.38 ? 132 PHE A N 1 ATOM 1013 C CA . PHE A 1 132 ? -33.433 -21.823 -29.406 1.00 28.85 ? 132 PHE A CA 1 ATOM 1014 C C . PHE A 1 132 ? -32.515 -20.637 -29.092 1.00 29.41 ? 132 PHE A C 1 ATOM 1015 O O . PHE A 1 132 ? -33.002 -19.545 -28.824 1.00 29.91 ? 132 PHE A O 1 ATOM 1016 C CB . PHE A 1 132 ? -33.583 -22.735 -28.202 1.00 29.94 ? 132 PHE A CB 1 ATOM 1017 C CG . PHE A 1 132 ? -34.384 -23.960 -28.502 1.00 31.01 ? 132 PHE A CG 1 ATOM 1018 C CD1 . PHE A 1 132 ? -35.781 -23.872 -28.658 1.00 33.96 ? 132 PHE A CD1 1 ATOM 1019 C CD2 . PHE A 1 132 ? -33.770 -25.185 -28.645 1.00 29.98 ? 132 PHE A CD2 1 ATOM 1020 C CE1 . PHE A 1 132 ? -36.552 -24.999 -28.941 1.00 30.76 ? 132 PHE A CE1 1 ATOM 1021 C CE2 . PHE A 1 132 ? -34.526 -26.329 -28.894 1.00 35.26 ? 132 PHE A CE2 1 ATOM 1022 C CZ . PHE A 1 132 ? -35.928 -26.234 -29.057 1.00 33.28 ? 132 PHE A CZ 1 ATOM 1023 N N . LEU A 1 133 ? -31.189 -20.833 -29.144 1.00 28.76 ? 133 LEU A N 1 ATOM 1024 C CA . LEU A 1 133 ? -30.226 -19.779 -28.834 1.00 27.93 ? 133 LEU A CA 1 ATOM 1025 C C . LEU A 1 133 ? -30.372 -18.623 -29.842 1.00 29.37 ? 133 LEU A C 1 ATOM 1026 O O . LEU A 1 133 ? -30.367 -17.404 -29.473 1.00 28.12 ? 133 LEU A O 1 ATOM 1027 C CB . LEU A 1 133 ? -28.800 -20.338 -28.881 1.00 26.65 ? 133 LEU A CB 1 ATOM 1028 C CG . LEU A 1 133 ? -28.408 -21.095 -27.593 1.00 26.93 ? 133 LEU A CG 1 ATOM 1029 C CD1 . LEU A 1 133 ? -27.135 -21.965 -27.765 1.00 24.78 ? 133 LEU A CD1 1 ATOM 1030 C CD2 . LEU A 1 133 ? -28.223 -20.149 -26.462 1.00 26.99 ? 133 LEU A CD2 1 ATOM 1031 N N . ALA A 1 134 ? -30.507 -19.007 -31.105 1.00 28.66 ? 134 ALA A N 1 ATOM 1032 C CA . ALA A 1 134 ? -30.541 -18.015 -32.184 1.00 31.04 ? 134 ALA A CA 1 ATOM 1033 C C . ALA A 1 134 ? -31.838 -17.200 -32.014 1.00 32.17 ? 134 ALA A C 1 ATOM 1034 O O . ALA A 1 134 ? -31.820 -15.960 -32.047 1.00 32.71 ? 134 ALA A O 1 ATOM 1035 C CB . ALA A 1 134 ? -30.477 -18.712 -33.573 1.00 29.78 ? 134 ALA A CB 1 ATOM 1036 N N . ARG A 1 135 ? -32.940 -17.896 -31.738 1.00 32.38 ? 135 ARG A N 1 ATOM 1037 C CA . ARG A 1 135 ? -34.200 -17.234 -31.543 1.00 33.51 ? 135 ARG A CA 1 ATOM 1038 C C . ARG A 1 135 ? -34.195 -16.298 -30.329 1.00 33.99 ? 135 ARG A C 1 ATOM 1039 O O . ARG A 1 135 ? -34.628 -15.130 -30.411 1.00 34.75 ? 135 ARG A O 1 ATOM 1040 C CB . ARG A 1 135 ? -35.278 -18.291 -31.357 1.00 33.91 ? 135 ARG A CB 1 ATOM 1041 C CG . ARG A 1 135 ? -36.664 -17.773 -30.961 1.00 35.90 ? 135 ARG A CG 1 ATOM 1042 C CD . ARG A 1 135 ? -37.354 -16.933 -32.079 1.00 41.99 ? 135 ARG A CD 1 ATOM 1043 N NE . ARG A 1 135 ? -38.702 -16.585 -31.640 1.00 46.38 ? 135 ARG A NE 1 ATOM 1044 C CZ . ARG A 1 135 ? -39.013 -15.473 -30.968 1.00 50.46 ? 135 ARG A CZ 1 ATOM 1045 N NH1 . ARG A 1 135 ? -38.078 -14.563 -30.709 1.00 50.86 ? 135 ARG A NH1 1 ATOM 1046 N NH2 . ARG A 1 135 ? -40.269 -15.247 -30.571 1.00 51.25 ? 135 ARG A NH2 1 ATOM 1047 N N . VAL A 1 136 ? -33.787 -16.847 -29.183 1.00 32.97 ? 136 VAL A N 1 ATOM 1048 C CA . VAL A 1 136 ? -33.908 -16.170 -27.917 1.00 31.53 ? 136 VAL A CA 1 ATOM 1049 C C . VAL A 1 136 ? -32.848 -15.087 -27.708 1.00 30.77 ? 136 VAL A C 1 ATOM 1050 O O . VAL A 1 136 ? -33.165 -14.046 -27.183 1.00 30.98 ? 136 VAL A O 1 ATOM 1051 C CB . VAL A 1 136 ? -33.899 -17.169 -26.755 1.00 32.27 ? 136 VAL A CB 1 ATOM 1052 C CG1 . VAL A 1 136 ? -33.823 -16.439 -25.418 1.00 31.31 ? 136 VAL A CG1 1 ATOM 1053 C CG2 . VAL A 1 136 ? -35.156 -18.005 -26.792 1.00 31.08 ? 136 VAL A CG2 1 ATOM 1054 N N . GLU A 1 137 ? -31.609 -15.311 -28.139 1.00 29.36 ? 137 GLU A N 1 ATOM 1055 C CA . GLU A 1 137 ? -30.519 -14.390 -27.860 1.00 28.33 ? 137 GLU A CA 1 ATOM 1056 C C . GLU A 1 137 ? -30.019 -13.686 -29.125 1.00 28.17 ? 137 GLU A C 1 ATOM 1057 O O . GLU A 1 137 ? -29.157 -12.807 -29.065 1.00 26.05 ? 137 GLU A O 1 ATOM 1058 C CB . GLU A 1 137 ? -29.370 -15.131 -27.141 1.00 28.17 ? 137 GLU A CB 1 ATOM 1059 C CG . GLU A 1 137 ? -29.729 -15.592 -25.738 1.00 27.02 ? 137 GLU A CG 1 ATOM 1060 C CD . GLU A 1 137 ? -29.979 -14.426 -24.722 1.00 29.65 ? 137 GLU A CD 1 ATOM 1061 O OE1 . GLU A 1 137 ? -29.304 -13.379 -24.801 1.00 29.77 ? 137 GLU A OE1 1 ATOM 1062 O OE2 . GLU A 1 137 ? -30.869 -14.546 -23.829 1.00 28.26 ? 137 GLU A OE2 1 ATOM 1063 N N . ARG A 1 138 ? -30.544 -14.082 -30.287 1.00 27.84 ? 138 ARG A N 1 ATOM 1064 C CA . ARG A 1 138 ? -30.177 -13.391 -31.513 1.00 27.63 ? 138 ARG A CA 1 ATOM 1065 C C . ARG A 1 138 ? -28.683 -13.530 -31.744 1.00 26.63 ? 138 ARG A C 1 ATOM 1066 O O . ARG A 1 138 ? -28.033 -12.668 -32.320 1.00 27.07 ? 138 ARG A O 1 ATOM 1067 C CB . ARG A 1 138 ? -30.550 -11.902 -31.433 1.00 28.14 ? 138 ARG A CB 1 ATOM 1068 C CG . ARG A 1 138 ? -31.988 -11.638 -30.906 1.00 32.80 ? 138 ARG A CG 1 ATOM 1069 C CD . ARG A 1 138 ? -33.049 -11.767 -31.974 1.00 37.10 ? 138 ARG A CD 1 ATOM 1070 N NE . ARG A 1 138 ? -32.686 -11.049 -33.203 0.50 37.21 ? 138 ARG A NE 1 ATOM 1071 C CZ . ARG A 1 138 ? -33.392 -11.082 -34.339 0.50 35.62 ? 138 ARG A CZ 1 ATOM 1072 N NH1 . ARG A 1 138 ? -34.516 -11.801 -34.398 0.50 30.79 ? 138 ARG A NH1 1 ATOM 1073 N NH2 . ARG A 1 138 ? -32.972 -10.389 -35.406 0.50 30.98 ? 138 ARG A NH2 1 ATOM 1074 N N . VAL A 1 139 ? -28.117 -14.631 -31.284 1.00 25.50 ? 139 VAL A N 1 ATOM 1075 C CA . VAL A 1 139 ? -26.772 -14.959 -31.687 1.00 24.23 ? 139 VAL A CA 1 ATOM 1076 C C . VAL A 1 139 ? -26.912 -15.919 -32.880 1.00 25.20 ? 139 VAL A C 1 ATOM 1077 O O . VAL A 1 139 ? -27.951 -16.533 -33.039 1.00 25.27 ? 139 VAL A O 1 ATOM 1078 C CB . VAL A 1 139 ? -26.000 -15.634 -30.528 1.00 23.69 ? 139 VAL A CB 1 ATOM 1079 C CG1 . VAL A 1 139 ? -25.695 -14.561 -29.375 1.00 22.62 ? 139 VAL A CG1 1 ATOM 1080 C CG2 . VAL A 1 139 ? -26.784 -16.780 -30.026 1.00 17.92 ? 139 VAL A CG2 1 ATOM 1081 N N . ILE A 1 140 ? -25.856 -16.055 -33.674 1.00 26.07 ? 140 ILE A N 1 ATOM 1082 C CA . ILE A 1 140 ? -25.709 -17.140 -34.644 1.00 25.55 ? 140 ILE A CA 1 ATOM 1083 C C . ILE A 1 140 ? -25.018 -18.324 -33.963 1.00 26.15 ? 140 ILE A C 1 ATOM 1084 O O . ILE A 1 140 ? -24.018 -18.143 -33.204 1.00 26.88 ? 140 ILE A O 1 ATOM 1085 C CB . ILE A 1 140 ? -24.862 -16.629 -35.788 1.00 25.48 ? 140 ILE A CB 1 ATOM 1086 C CG1 . ILE A 1 140 ? -25.684 -15.594 -36.577 1.00 25.49 ? 140 ILE A CG1 1 ATOM 1087 C CG2 . ILE A 1 140 ? -24.354 -17.767 -36.688 1.00 25.15 ? 140 ILE A CG2 1 ATOM 1088 C CD1 . ILE A 1 140 ? -24.922 -14.950 -37.714 1.00 26.54 ? 140 ILE A CD1 1 ATOM 1089 N N . VAL A 1 141 ? -25.564 -19.516 -34.155 1.00 24.79 ? 141 VAL A N 1 ATOM 1090 C CA . VAL A 1 141 ? -24.946 -20.763 -33.661 1.00 23.40 ? 141 VAL A CA 1 ATOM 1091 C C . VAL A 1 141 ? -24.406 -21.583 -34.840 1.00 25.05 ? 141 VAL A C 1 ATOM 1092 O O . VAL A 1 141 ? -25.122 -21.789 -35.862 1.00 26.28 ? 141 VAL A O 1 ATOM 1093 C CB . VAL A 1 141 ? -25.981 -21.546 -32.884 1.00 22.73 ? 141 VAL A CB 1 ATOM 1094 C CG1 . VAL A 1 141 ? -25.407 -22.881 -32.250 1.00 21.04 ? 141 VAL A CG1 1 ATOM 1095 C CG2 . VAL A 1 141 ? -26.564 -20.641 -31.866 1.00 19.84 ? 141 VAL A CG2 1 ATOM 1096 N N . VAL A 1 142 ? -23.146 -22.008 -34.748 1.00 23.79 ? 142 VAL A N 1 ATOM 1097 C CA . VAL A 1 142 ? -22.534 -22.878 -35.728 1.00 22.82 ? 142 VAL A CA 1 ATOM 1098 C C . VAL A 1 142 ? -22.079 -24.143 -34.963 1.00 24.03 ? 142 VAL A C 1 ATOM 1099 O O . VAL A 1 142 ? -21.704 -24.077 -33.733 1.00 22.77 ? 142 VAL A O 1 ATOM 1100 C CB . VAL A 1 142 ? -21.321 -22.209 -36.390 1.00 23.44 ? 142 VAL A CB 1 ATOM 1101 C CG1 . VAL A 1 142 ? -20.526 -23.163 -37.277 1.00 21.96 ? 142 VAL A CG1 1 ATOM 1102 C CG2 . VAL A 1 142 ? -21.712 -20.938 -37.145 1.00 22.80 ? 142 VAL A CG2 1 ATOM 1103 N N . SER A 1 143 ? -22.133 -25.293 -35.654 1.00 23.47 ? 143 SER A N 1 ATOM 1104 C CA . SER A 1 143 ? -21.595 -26.549 -35.119 1.00 22.48 ? 143 SER A CA 1 ATOM 1105 C C . SER A 1 143 ? -21.088 -27.396 -36.272 1.00 23.30 ? 143 SER A C 1 ATOM 1106 O O . SER A 1 143 ? -21.595 -27.274 -37.348 1.00 22.84 ? 143 SER A O 1 ATOM 1107 C CB . SER A 1 143 ? -22.649 -27.249 -34.299 1.00 21.42 ? 143 SER A CB 1 ATOM 1108 O OG . SER A 1 143 ? -23.738 -27.725 -35.061 1.00 25.88 ? 143 SER A OG 1 ATOM 1109 N N . MET A 1 144 ? -20.044 -28.203 -36.078 1.00 23.81 ? 144 MET A N 1 ATOM 1110 C CA . MET A 1 144 ? -19.433 -28.931 -37.170 1.00 23.25 ? 144 MET A CA 1 ATOM 1111 C C . MET A 1 144 ? -19.253 -30.410 -36.779 1.00 25.14 ? 144 MET A C 1 ATOM 1112 O O . MET A 1 144 ? -18.994 -30.724 -35.555 1.00 24.19 ? 144 MET A O 1 ATOM 1113 C CB . MET A 1 144 ? -18.056 -28.328 -37.518 1.00 23.46 ? 144 MET A CB 1 ATOM 1114 C CG . MET A 1 144 ? -16.904 -28.916 -36.752 1.00 23.49 ? 144 MET A CG 1 ATOM 1115 S SD . MET A 1 144 ? -16.900 -28.348 -34.997 1.00 24.39 ? 144 MET A SD 1 ATOM 1116 C CE . MET A 1 144 ? -16.429 -26.615 -35.161 1.00 15.17 ? 144 MET A CE 1 ATOM 1117 N N . ASN A 1 145 ? -19.354 -31.328 -37.776 1.00 23.41 ? 145 ASN A N 1 ATOM 1118 C CA . ASN A 1 145 ? -18.852 -32.690 -37.561 1.00 23.85 ? 145 ASN A CA 1 ATOM 1119 C C . ASN A 1 145 ? -17.389 -32.719 -37.852 1.00 24.17 ? 145 ASN A C 1 ATOM 1120 O O . ASN A 1 145 ? -16.908 -32.068 -38.801 1.00 24.42 ? 145 ASN A O 1 ATOM 1121 C CB . ASN A 1 145 ? -19.591 -33.805 -38.362 1.00 23.93 ? 145 ASN A CB 1 ATOM 1122 C CG . ASN A 1 145 ? -21.021 -33.859 -38.048 1.00 24.16 ? 145 ASN A CG 1 ATOM 1123 O OD1 . ASN A 1 145 ? -21.474 -33.286 -37.041 1.00 26.18 ? 145 ASN A OD1 1 ATOM 1124 N ND2 . ASN A 1 145 ? -21.801 -34.528 -38.907 1.00 28.06 ? 145 ASN A ND2 1 ATOM 1125 N N . TYR A 1 146 ? -16.656 -33.384 -36.954 1.00 23.71 ? 146 TYR A N 1 ATOM 1126 C CA . TYR A 1 146 ? -15.243 -33.598 -37.156 1.00 22.39 ? 146 TYR A CA 1 ATOM 1127 C C . TYR A 1 146 ? -15.028 -35.123 -36.949 1.00 22.35 ? 146 TYR A C 1 ATOM 1128 O O . TYR A 1 146 ? -15.822 -35.753 -36.245 1.00 21.76 ? 146 TYR A O 1 ATOM 1129 C CB . TYR A 1 146 ? -14.413 -32.710 -36.173 1.00 21.58 ? 146 TYR A CB 1 ATOM 1130 C CG . TYR A 1 146 ? -14.632 -33.071 -34.715 1.00 18.39 ? 146 TYR A CG 1 ATOM 1131 C CD1 . TYR A 1 146 ? -13.872 -34.026 -34.106 1.00 19.55 ? 146 TYR A CD1 1 ATOM 1132 C CD2 . TYR A 1 146 ? -15.637 -32.451 -33.945 1.00 19.40 ? 146 TYR A CD2 1 ATOM 1133 C CE1 . TYR A 1 146 ? -14.089 -34.405 -32.765 1.00 15.41 ? 146 TYR A CE1 1 ATOM 1134 C CE2 . TYR A 1 146 ? -15.837 -32.789 -32.547 1.00 17.24 ? 146 TYR A CE2 1 ATOM 1135 C CZ . TYR A 1 146 ? -15.057 -33.752 -31.989 1.00 19.23 ? 146 TYR A CZ 1 ATOM 1136 O OH . TYR A 1 146 ? -15.285 -34.126 -30.650 1.00 20.31 ? 146 TYR A OH 1 ATOM 1137 N N . ARG A 1 147 ? -13.984 -35.691 -37.577 1.00 22.74 ? 147 ARG A N 1 ATOM 1138 C CA . ARG A 1 147 ? -13.671 -37.111 -37.515 1.00 22.66 ? 147 ARG A CA 1 ATOM 1139 C C . ARG A 1 147 ? -13.214 -37.513 -36.132 1.00 23.73 ? 147 ARG A C 1 ATOM 1140 O O . ARG A 1 147 ? -12.522 -36.741 -35.448 1.00 23.20 ? 147 ARG A O 1 ATOM 1141 C CB . ARG A 1 147 ? -12.542 -37.445 -38.475 1.00 22.21 ? 147 ARG A CB 1 ATOM 1142 C CG . ARG A 1 147 ? -12.924 -37.265 -39.974 1.00 24.24 ? 147 ARG A CG 1 ATOM 1143 C CD . ARG A 1 147 ? -11.680 -37.478 -40.854 1.00 24.94 ? 147 ARG A CD 1 ATOM 1144 N NE . ARG A 1 147 ? -11.004 -36.215 -41.033 1.00 25.07 ? 147 ARG A NE 1 ATOM 1145 C CZ . ARG A 1 147 ? -9.860 -36.030 -41.694 1.00 27.60 ? 147 ARG A CZ 1 ATOM 1146 N NH1 . ARG A 1 147 ? -9.205 -37.052 -42.256 1.00 28.38 ? 147 ARG A NH1 1 ATOM 1147 N NH2 . ARG A 1 147 ? -9.364 -34.798 -41.783 1.00 26.79 ? 147 ARG A NH2 1 ATOM 1148 N N . VAL A 1 148 ? -13.577 -38.730 -35.750 1.00 22.48 ? 148 VAL A N 1 ATOM 1149 C CA . VAL A 1 148 ? -13.357 -39.225 -34.417 1.00 23.43 ? 148 VAL A CA 1 ATOM 1150 C C . VAL A 1 148 ? -12.797 -40.650 -34.547 1.00 24.69 ? 148 VAL A C 1 ATOM 1151 O O . VAL A 1 148 ? -12.748 -41.192 -35.670 1.00 23.55 ? 148 VAL A O 1 ATOM 1152 C CB . VAL A 1 148 ? -14.680 -39.223 -33.670 1.00 24.84 ? 148 VAL A CB 1 ATOM 1153 C CG1 . VAL A 1 148 ? -15.087 -37.778 -33.345 1.00 21.40 ? 148 VAL A CG1 1 ATOM 1154 C CG2 . VAL A 1 148 ? -15.790 -39.914 -34.544 1.00 20.03 ? 148 VAL A CG2 1 ATOM 1155 N N . GLY A 1 149 ? -12.356 -41.238 -33.442 1.00 22.60 ? 149 GLY A N 1 ATOM 1156 C CA . GLY A 1 149 ? -11.683 -42.518 -33.498 1.00 23.16 ? 149 GLY A CA 1 ATOM 1157 C C . GLY A 1 149 ? -10.381 -42.502 -34.276 1.00 24.05 ? 149 GLY A C 1 ATOM 1158 O O . GLY A 1 149 ? -9.776 -41.449 -34.475 1.00 24.77 ? 149 GLY A O 1 ATOM 1159 N N . ALA A 1 150 ? -9.933 -43.666 -34.753 1.00 24.12 ? 150 ALA A N 1 ATOM 1160 C CA . ALA A 1 150 ? -8.702 -43.756 -35.516 1.00 24.93 ? 150 ALA A CA 1 ATOM 1161 C C . ALA A 1 150 ? -8.746 -42.890 -36.729 1.00 26.01 ? 150 ALA A C 1 ATOM 1162 O O . ALA A 1 150 ? -7.732 -42.368 -37.134 1.00 27.98 ? 150 ALA A O 1 ATOM 1163 C CB . ALA A 1 150 ? -8.432 -45.205 -35.940 1.00 26.26 ? 150 ALA A CB 1 ATOM 1164 N N . LEU A 1 151 ? -9.906 -42.780 -37.354 1.00 26.05 ? 151 LEU A N 1 ATOM 1165 C CA . LEU A 1 151 ? -10.029 -42.003 -38.578 1.00 27.66 ? 151 LEU A CA 1 ATOM 1166 C C . LEU A 1 151 ? -9.778 -40.502 -38.380 1.00 29.29 ? 151 LEU A C 1 ATOM 1167 O O . LEU A 1 151 ? -9.414 -39.788 -39.329 1.00 29.73 ? 151 LEU A O 1 ATOM 1168 C CB . LEU A 1 151 ? -11.438 -42.223 -39.175 1.00 27.12 ? 151 LEU A CB 1 ATOM 1169 C CG . LEU A 1 151 ? -11.671 -43.635 -39.792 1.00 27.26 ? 151 LEU A CG 1 ATOM 1170 C CD1 . LEU A 1 151 ? -13.172 -43.884 -39.971 1.00 27.25 ? 151 LEU A CD1 1 ATOM 1171 C CD2 . LEU A 1 151 ? -10.870 -43.854 -41.112 1.00 25.88 ? 151 LEU A CD2 1 ATOM 1172 N N . GLY A 1 152 ? -10.009 -40.019 -37.148 1.00 29.29 ? 152 GLY A N 1 ATOM 1173 C CA . GLY A 1 152 ? -9.750 -38.623 -36.796 1.00 28.22 ? 152 GLY A CA 1 ATOM 1174 C C . GLY A 1 152 ? -8.445 -38.466 -36.034 1.00 28.96 ? 152 GLY A C 1 ATOM 1175 O O . GLY A 1 152 ? -7.874 -37.385 -36.022 1.00 30.72 ? 152 GLY A O 1 ATOM 1176 N N . PHE A 1 153 ? -7.933 -39.503 -35.390 1.00 27.91 ? 153 PHE A N 1 ATOM 1177 C CA . PHE A 1 153 ? -6.780 -39.253 -34.517 1.00 27.83 ? 153 PHE A CA 1 ATOM 1178 C C . PHE A 1 153 ? -5.615 -40.223 -34.587 1.00 28.45 ? 153 PHE A C 1 ATOM 1179 O O . PHE A 1 153 ? -4.594 -40.065 -33.883 1.00 28.22 ? 153 PHE A O 1 ATOM 1180 C CB . PHE A 1 153 ? -7.267 -39.088 -33.083 1.00 27.81 ? 153 PHE A CB 1 ATOM 1181 C CG . PHE A 1 153 ? -8.084 -37.835 -32.877 1.00 25.37 ? 153 PHE A CG 1 ATOM 1182 C CD1 . PHE A 1 153 ? -7.461 -36.624 -32.614 1.00 23.58 ? 153 PHE A CD1 1 ATOM 1183 C CD2 . PHE A 1 153 ? -9.464 -37.874 -32.956 1.00 23.28 ? 153 PHE A CD2 1 ATOM 1184 C CE1 . PHE A 1 153 ? -8.202 -35.454 -32.396 1.00 20.83 ? 153 PHE A CE1 1 ATOM 1185 C CE2 . PHE A 1 153 ? -10.233 -36.694 -32.778 1.00 19.42 ? 153 PHE A CE2 1 ATOM 1186 C CZ . PHE A 1 153 ? -9.605 -35.502 -32.501 1.00 20.08 ? 153 PHE A CZ 1 ATOM 1187 N N . LEU A 1 154 ? -5.739 -41.240 -35.442 1.00 29.84 ? 154 LEU A N 1 ATOM 1188 C CA . LEU A 1 154 ? -4.589 -42.136 -35.674 1.00 31.54 ? 154 LEU A CA 1 ATOM 1189 C C . LEU A 1 154 ? -3.312 -41.314 -35.894 1.00 32.56 ? 154 LEU A C 1 ATOM 1190 O O . LEU A 1 154 ? -3.296 -40.360 -36.637 1.00 32.46 ? 154 LEU A O 1 ATOM 1191 C CB . LEU A 1 154 ? -4.828 -43.013 -36.897 1.00 31.42 ? 154 LEU A CB 1 ATOM 1192 C CG . LEU A 1 154 ? -3.733 -44.017 -37.253 1.00 31.96 ? 154 LEU A CG 1 ATOM 1193 C CD1 . LEU A 1 154 ? -4.254 -45.396 -36.929 1.00 31.15 ? 154 LEU A CD1 1 ATOM 1194 C CD2 . LEU A 1 154 ? -3.384 -43.927 -38.729 1.00 32.22 ? 154 LEU A CD2 1 ATOM 1195 N N . ALA A 1 155 ? -2.230 -41.725 -35.283 1.00 34.33 ? 155 ALA A N 1 ATOM 1196 C CA . ALA A 1 155 ? -1.015 -40.962 -35.377 1.00 37.23 ? 155 ALA A CA 1 ATOM 1197 C C . ALA A 1 155 ? 0.219 -41.839 -35.620 1.00 39.17 ? 155 ALA A C 1 ATOM 1198 O O . ALA A 1 155 ? 0.535 -42.790 -34.870 1.00 36.90 ? 155 ALA A O 1 ATOM 1199 C CB . ALA A 1 155 ? -0.809 -40.062 -34.074 1.00 36.57 ? 155 ALA A CB 1 ATOM 1200 N N . LEU A 1 156 ? 0.916 -41.470 -36.674 1.00 42.48 ? 156 LEU A N 1 ATOM 1201 C CA . LEU A 1 156 ? 2.209 -42.031 -36.950 1.00 46.71 ? 156 LEU A CA 1 ATOM 1202 C C . LEU A 1 156 ? 3.021 -40.755 -37.019 1.00 48.91 ? 156 LEU A C 1 ATOM 1203 O O . LEU A 1 156 ? 3.043 -40.065 -38.056 1.00 49.50 ? 156 LEU A O 1 ATOM 1204 C CB . LEU A 1 156 ? 2.157 -42.757 -38.296 1.00 46.91 ? 156 LEU A CB 1 ATOM 1205 C CG . LEU A 1 156 ? 2.813 -44.134 -38.306 1.00 48.20 ? 156 LEU A CG 1 ATOM 1206 C CD1 . LEU A 1 156 ? 2.885 -44.731 -36.922 1.00 47.43 ? 156 LEU A CD1 1 ATOM 1207 C CD2 . LEU A 1 156 ? 2.006 -45.022 -39.250 1.00 50.83 ? 156 LEU A CD2 1 ATOM 1208 N N . PRO A 1 157 ? 3.642 -40.402 -35.884 1.00 51.01 ? 157 PRO A N 1 ATOM 1209 C CA . PRO A 1 157 ? 4.216 -39.083 -35.626 1.00 52.27 ? 157 PRO A CA 1 ATOM 1210 C C . PRO A 1 157 ? 5.167 -38.534 -36.719 1.00 53.22 ? 157 PRO A C 1 ATOM 1211 O O . PRO A 1 157 ? 6.119 -39.217 -37.151 1.00 53.69 ? 157 PRO A O 1 ATOM 1212 C CB . PRO A 1 157 ? 4.941 -39.295 -34.291 1.00 52.64 ? 157 PRO A CB 1 ATOM 1213 C CG . PRO A 1 157 ? 4.052 -40.316 -33.576 1.00 51.81 ? 157 PRO A CG 1 ATOM 1214 C CD . PRO A 1 157 ? 3.717 -41.284 -34.695 1.00 51.63 ? 157 PRO A CD 1 ATOM 1215 N N . GLY A 1 158 ? 4.896 -37.309 -37.162 1.00 53.04 ? 158 GLY A N 1 ATOM 1216 C CA . GLY A 1 158 ? 5.769 -36.648 -38.126 1.00 53.31 ? 158 GLY A CA 1 ATOM 1217 C C . GLY A 1 158 ? 5.492 -37.020 -39.573 1.00 53.51 ? 158 GLY A C 1 ATOM 1218 O O . GLY A 1 158 ? 5.975 -36.348 -40.513 1.00 53.53 ? 158 GLY A O 1 ATOM 1219 N N . ASN A 1 159 ? 4.688 -38.077 -39.750 1.00 53.23 ? 159 ASN A N 1 ATOM 1220 C CA . ASN A 1 159 ? 4.368 -38.644 -41.073 1.00 51.35 ? 159 ASN A CA 1 ATOM 1221 C C . ASN A 1 159 ? 3.036 -38.128 -41.598 1.00 50.79 ? 159 ASN A C 1 ATOM 1222 O O . ASN A 1 159 ? 1.990 -38.471 -41.035 1.00 50.52 ? 159 ASN A O 1 ATOM 1223 C CB . ASN A 1 159 ? 4.304 -40.149 -40.909 1.00 51.47 ? 159 ASN A CB 1 ATOM 1224 C CG . ASN A 1 159 ? 4.023 -40.872 -42.198 1.00 51.39 ? 159 ASN A CG 1 ATOM 1225 O OD1 . ASN A 1 159 ? 3.493 -40.299 -43.161 1.00 49.72 ? 159 ASN A OD1 1 ATOM 1226 N ND2 . ASN A 1 159 ? 4.331 -42.158 -42.210 1.00 50.95 ? 159 ASN A ND2 1 ATOM 1227 N N . PRO A 1 160 ? 3.057 -37.310 -42.683 1.00 49.79 ? 160 PRO A N 1 ATOM 1228 C CA . PRO A 1 160 ? 1.857 -36.585 -43.128 1.00 48.73 ? 160 PRO A CA 1 ATOM 1229 C C . PRO A 1 160 ? 0.764 -37.473 -43.707 1.00 48.37 ? 160 PRO A C 1 ATOM 1230 O O . PRO A 1 160 ? -0.304 -36.971 -44.129 1.00 48.58 ? 160 PRO A O 1 ATOM 1231 C CB . PRO A 1 160 ? 2.381 -35.614 -44.184 1.00 48.71 ? 160 PRO A CB 1 ATOM 1232 C CG . PRO A 1 160 ? 3.694 -36.159 -44.600 1.00 48.92 ? 160 PRO A CG 1 ATOM 1233 C CD . PRO A 1 160 ? 4.251 -36.966 -43.480 1.00 50.03 ? 160 PRO A CD 1 ATOM 1234 N N . GLU A 1 161 ? 1.025 -38.777 -43.732 1.00 47.16 ? 161 GLU A N 1 ATOM 1235 C CA . GLU A 1 161 ? 0.026 -39.740 -44.192 1.00 45.62 ? 161 GLU A CA 1 ATOM 1236 C C . GLU A 1 161 ? -0.920 -40.054 -43.044 1.00 43.66 ? 161 GLU A C 1 ATOM 1237 O O . GLU A 1 161 ? -2.091 -40.360 -43.274 1.00 44.25 ? 161 GLU A O 1 ATOM 1238 C CB . GLU A 1 161 ? 0.689 -41.021 -44.752 1.00 45.88 ? 161 GLU A CB 1 ATOM 1239 C CG . GLU A 1 161 ? 1.556 -40.768 -45.995 1.00 48.29 ? 161 GLU A CG 1 ATOM 1240 C CD . GLU A 1 161 ? 0.808 -40.002 -47.105 1.00 53.98 ? 161 GLU A CD 1 ATOM 1241 O OE1 . GLU A 1 161 ? -0.384 -40.280 -47.352 1.00 56.41 ? 161 GLU A OE1 1 ATOM 1242 O OE2 . GLU A 1 161 ? 1.408 -39.117 -47.755 1.00 56.69 ? 161 GLU A OE2 1 ATOM 1243 N N . ALA A 1 162 ? -0.399 -39.963 -41.824 1.00 41.03 ? 162 ALA A N 1 ATOM 1244 C CA . ALA A 1 162 ? -1.188 -40.102 -40.576 1.00 38.54 ? 162 ALA A CA 1 ATOM 1245 C C . ALA A 1 162 ? -0.570 -39.235 -39.509 1.00 36.02 ? 162 ALA A C 1 ATOM 1246 O O . ALA A 1 162 ? 0.174 -39.740 -38.647 1.00 35.35 ? 162 ALA A O 1 ATOM 1247 C CB . ALA A 1 162 ? -1.222 -41.568 -40.081 1.00 38.85 ? 162 ALA A CB 1 ATOM 1248 N N . PRO A 1 163 ? -0.822 -37.921 -39.572 1.00 34.19 ? 163 PRO A N 1 ATOM 1249 C CA . PRO A 1 163 ? 0.045 -37.160 -38.666 1.00 33.11 ? 163 PRO A CA 1 ATOM 1250 C C . PRO A 1 163 ? -0.523 -37.016 -37.256 1.00 31.67 ? 163 PRO A C 1 ATOM 1251 O O . PRO A 1 163 ? 0.236 -36.717 -36.340 1.00 32.27 ? 163 PRO A O 1 ATOM 1252 C CB . PRO A 1 163 ? 0.210 -35.802 -39.368 1.00 32.94 ? 163 PRO A CB 1 ATOM 1253 C CG . PRO A 1 163 ? -1.007 -35.653 -40.243 1.00 32.89 ? 163 PRO A CG 1 ATOM 1254 C CD . PRO A 1 163 ? -1.512 -37.070 -40.569 1.00 34.31 ? 163 PRO A CD 1 ATOM 1255 N N . GLY A 1 164 ? -1.826 -37.252 -37.096 1.00 29.52 ? 164 GLY A N 1 ATOM 1256 C CA . GLY A 1 164 ? -2.504 -37.145 -35.817 1.00 27.36 ? 164 GLY A CA 1 ATOM 1257 C C . GLY A 1 164 ? -3.354 -35.890 -35.807 1.00 26.52 ? 164 GLY A C 1 ATOM 1258 O O . GLY A 1 164 ? -3.202 -35.045 -36.674 1.00 25.64 ? 164 GLY A O 1 ATOM 1259 N N . ASN A 1 165 ? -4.254 -35.765 -34.829 1.00 25.25 ? 165 ASN A N 1 ATOM 1260 C CA . ASN A 1 165 ? -5.040 -34.534 -34.662 1.00 24.49 ? 165 ASN A CA 1 ATOM 1261 C C . ASN A 1 165 ? -5.883 -34.107 -35.833 1.00 25.03 ? 165 ASN A C 1 ATOM 1262 O O . ASN A 1 165 ? -6.321 -32.946 -35.902 1.00 23.57 ? 165 ASN A O 1 ATOM 1263 C CB . ASN A 1 165 ? -4.116 -33.359 -34.319 1.00 24.02 ? 165 ASN A CB 1 ATOM 1264 C CG . ASN A 1 165 ? -3.429 -33.560 -33.000 1.00 25.01 ? 165 ASN A CG 1 ATOM 1265 O OD1 . ASN A 1 165 ? -3.821 -34.461 -32.224 1.00 21.07 ? 165 ASN A OD1 1 ATOM 1266 N ND2 . ASN A 1 165 ? -2.384 -32.774 -32.740 1.00 22.67 ? 165 ASN A ND2 1 ATOM 1267 N N . MET A 1 166 ? -6.103 -35.014 -36.769 1.00 25.83 ? 166 MET A N 1 ATOM 1268 C CA . MET A 1 166 ? -6.894 -34.651 -37.946 1.00 26.05 ? 166 MET A CA 1 ATOM 1269 C C . MET A 1 166 ? -8.239 -34.093 -37.549 1.00 25.38 ? 166 MET A C 1 ATOM 1270 O O . MET A 1 166 ? -8.720 -33.116 -38.139 1.00 25.28 ? 166 MET A O 1 ATOM 1271 C CB . MET A 1 166 ? -7.070 -35.881 -38.861 1.00 27.47 ? 166 MET A CB 1 ATOM 1272 C CG . MET A 1 166 ? -5.742 -36.456 -39.357 1.00 26.56 ? 166 MET A CG 1 ATOM 1273 S SD . MET A 1 166 ? -4.812 -37.559 -38.268 1.00 31.74 ? 166 MET A SD 1 ATOM 1274 C CE . MET A 1 166 ? -5.918 -38.968 -38.273 1.00 28.55 ? 166 MET A CE 1 ATOM 1275 N N . GLY A 1 167 ? -8.876 -34.717 -36.561 1.00 24.87 ? 167 GLY A N 1 ATOM 1276 C CA . GLY A 1 167 ? -10.225 -34.241 -36.143 1.00 24.34 ? 167 GLY A CA 1 ATOM 1277 C C . GLY A 1 167 ? -10.173 -32.842 -35.513 1.00 24.22 ? 167 GLY A C 1 ATOM 1278 O O . GLY A 1 167 ? -11.136 -32.080 -35.548 1.00 24.16 ? 167 GLY A O 1 ATOM 1279 N N . LEU A 1 168 ? -9.033 -32.506 -34.911 1.00 23.84 ? 168 LEU A N 1 ATOM 1280 C CA . LEU A 1 168 ? -8.808 -31.153 -34.388 1.00 23.39 ? 168 LEU A CA 1 ATOM 1281 C C . LEU A 1 168 ? -8.571 -30.184 -35.590 1.00 23.35 ? 168 LEU A C 1 ATOM 1282 O O . LEU A 1 168 ? -9.020 -29.022 -35.551 1.00 22.58 ? 168 LEU A O 1 ATOM 1283 C CB . LEU A 1 168 ? -7.622 -31.147 -33.409 1.00 22.05 ? 168 LEU A CB 1 ATOM 1284 C CG . LEU A 1 168 ? -7.965 -31.712 -32.012 1.00 19.22 ? 168 LEU A CG 1 ATOM 1285 C CD1 . LEU A 1 168 ? -6.644 -31.871 -31.308 1.00 13.56 ? 168 LEU A CD1 1 ATOM 1286 C CD2 . LEU A 1 168 ? -8.878 -30.736 -31.241 1.00 14.66 ? 168 LEU A CD2 1 ATOM 1287 N N . PHE A 1 169 ? -7.862 -30.646 -36.641 1.00 22.45 ? 169 PHE A N 1 ATOM 1288 C CA . PHE A 1 169 ? -7.768 -29.835 -37.876 1.00 23.18 ? 169 PHE A CA 1 ATOM 1289 C C . PHE A 1 169 ? -9.107 -29.674 -38.648 1.00 23.03 ? 169 PHE A C 1 ATOM 1290 O O . PHE A 1 169 ? -9.365 -28.661 -39.304 1.00 24.23 ? 169 PHE A O 1 ATOM 1291 C CB . PHE A 1 169 ? -6.649 -30.358 -38.781 1.00 23.79 ? 169 PHE A CB 1 ATOM 1292 C CG . PHE A 1 169 ? -5.275 -29.921 -38.348 1.00 24.26 ? 169 PHE A CG 1 ATOM 1293 C CD1 . PHE A 1 169 ? -4.377 -30.836 -37.848 1.00 23.86 ? 169 PHE A CD1 1 ATOM 1294 C CD2 . PHE A 1 169 ? -4.895 -28.596 -38.472 1.00 23.86 ? 169 PHE A CD2 1 ATOM 1295 C CE1 . PHE A 1 169 ? -3.129 -30.441 -37.453 1.00 29.93 ? 169 PHE A CE1 1 ATOM 1296 C CE2 . PHE A 1 169 ? -3.636 -28.188 -38.092 1.00 27.78 ? 169 PHE A CE2 1 ATOM 1297 C CZ . PHE A 1 169 ? -2.754 -29.110 -37.558 1.00 28.45 ? 169 PHE A CZ 1 ATOM 1298 N N . ASP A 1 170 ? -9.977 -30.680 -38.586 1.00 23.12 ? 170 ASP A N 1 ATOM 1299 C CA . ASP A 1 170 ? -11.339 -30.498 -39.102 1.00 22.82 ? 170 ASP A CA 1 ATOM 1300 C C . ASP A 1 170 ? -12.061 -29.325 -38.350 1.00 23.24 ? 170 ASP A C 1 ATOM 1301 O O . ASP A 1 170 ? -12.675 -28.424 -38.976 1.00 23.30 ? 170 ASP A O 1 ATOM 1302 C CB . ASP A 1 170 ? -12.167 -31.799 -38.964 1.00 21.91 ? 170 ASP A CB 1 ATOM 1303 C CG . ASP A 1 170 ? -11.581 -32.975 -39.774 1.00 24.46 ? 170 ASP A CG 1 ATOM 1304 O OD1 . ASP A 1 170 ? -10.804 -32.758 -40.693 1.00 26.81 ? 170 ASP A OD1 1 ATOM 1305 O OD2 . ASP A 1 170 ? -11.873 -34.144 -39.471 1.00 25.58 ? 170 ASP A OD2 1 ATOM 1306 N N . GLN A 1 171 ? -12.060 -29.379 -37.005 1.00 21.52 ? 171 GLN A N 1 ATOM 1307 C CA . GLN A 1 171 ? -12.643 -28.297 -36.225 1.00 20.62 ? 171 GLN A CA 1 ATOM 1308 C C . GLN A 1 171 ? -12.005 -26.956 -36.685 1.00 21.33 ? 171 GLN A C 1 ATOM 1309 O O . GLN A 1 171 ? -12.694 -25.955 -36.891 1.00 21.88 ? 171 GLN A O 1 ATOM 1310 C CB . GLN A 1 171 ? -12.432 -28.512 -34.718 1.00 19.18 ? 171 GLN A CB 1 ATOM 1311 C CG . GLN A 1 171 ? -12.995 -29.823 -34.151 1.00 18.09 ? 171 GLN A CG 1 ATOM 1312 C CD . GLN A 1 171 ? -12.510 -30.017 -32.742 1.00 24.69 ? 171 GLN A CD 1 ATOM 1313 O OE1 . GLN A 1 171 ? -11.973 -29.055 -32.166 1.00 23.77 ? 171 GLN A OE1 1 ATOM 1314 N NE2 . GLN A 1 171 ? -12.740 -31.202 -32.147 1.00 21.09 ? 171 GLN A NE2 1 ATOM 1315 N N . GLN A 1 172 ? -10.700 -26.935 -36.844 1.00 22.98 ? 172 GLN A N 1 ATOM 1316 C CA . GLN A 1 172 ? -10.015 -25.685 -37.183 1.00 24.53 ? 172 GLN A CA 1 ATOM 1317 C C . GLN A 1 172 ? -10.430 -25.121 -38.543 1.00 26.37 ? 172 GLN A C 1 ATOM 1318 O O . GLN A 1 172 ? -10.557 -23.910 -38.716 1.00 26.55 ? 172 GLN A O 1 ATOM 1319 C CB . GLN A 1 172 ? -8.513 -25.903 -37.202 1.00 25.11 ? 172 GLN A CB 1 ATOM 1320 C CG . GLN A 1 172 ? -7.729 -24.584 -37.168 1.00 25.97 ? 172 GLN A CG 1 ATOM 1321 C CD . GLN A 1 172 ? -6.227 -24.793 -37.110 1.00 28.66 ? 172 GLN A CD 1 ATOM 1322 O OE1 . GLN A 1 172 ? -5.591 -24.627 -36.052 1.00 32.89 ? 172 GLN A OE1 1 ATOM 1323 N NE2 . GLN A 1 172 ? -5.642 -25.173 -38.239 1.00 25.81 ? 172 GLN A NE2 1 ATOM 1324 N N . LEU A 1 173 ? -10.621 -26.005 -39.514 1.00 25.93 ? 173 LEU A N 1 ATOM 1325 C CA . LEU A 1 173 ? -10.993 -25.592 -40.872 1.00 25.73 ? 173 LEU A CA 1 ATOM 1326 C C . LEU A 1 173 ? -12.424 -25.110 -40.824 1.00 25.34 ? 173 LEU A C 1 ATOM 1327 O O . LEU A 1 173 ? -12.786 -24.147 -41.487 1.00 26.22 ? 173 LEU A O 1 ATOM 1328 C CB . LEU A 1 173 ? -10.874 -26.783 -41.851 1.00 26.48 ? 173 LEU A CB 1 ATOM 1329 C CG . LEU A 1 173 ? -11.033 -26.488 -43.364 1.00 29.58 ? 173 LEU A CG 1 ATOM 1330 C CD1 . LEU A 1 173 ? -10.097 -25.353 -43.825 1.00 28.78 ? 173 LEU A CD1 1 ATOM 1331 C CD2 . LEU A 1 173 ? -10.732 -27.733 -44.152 1.00 29.47 ? 173 LEU A CD2 1 ATOM 1332 N N . ALA A 1 174 ? -13.260 -25.740 -40.013 1.00 25.16 ? 174 ALA A N 1 ATOM 1333 C CA . ALA A 1 174 ? -14.579 -25.158 -39.748 1.00 24.15 ? 174 ALA A CA 1 ATOM 1334 C C . ALA A 1 174 ? -14.517 -23.748 -39.165 1.00 24.36 ? 174 ALA A C 1 ATOM 1335 O O . ALA A 1 174 ? -15.306 -22.856 -39.556 1.00 23.50 ? 174 ALA A O 1 ATOM 1336 C CB . ALA A 1 174 ? -15.376 -26.057 -38.834 1.00 25.42 ? 174 ALA A CB 1 ATOM 1337 N N . LEU A 1 175 ? -13.631 -23.517 -38.190 1.00 24.25 ? 175 LEU A N 1 ATOM 1338 C CA . LEU A 1 175 ? -13.478 -22.130 -37.633 1.00 23.82 ? 175 LEU A CA 1 ATOM 1339 C C . LEU A 1 175 ? -13.012 -21.138 -38.757 1.00 24.65 ? 175 LEU A C 1 ATOM 1340 O O . LEU A 1 175 ? -13.428 -19.997 -38.807 1.00 23.50 ? 175 LEU A O 1 ATOM 1341 C CB . LEU A 1 175 ? -12.440 -22.132 -36.531 1.00 24.13 ? 175 LEU A CB 1 ATOM 1342 C CG . LEU A 1 175 ? -12.576 -23.180 -35.425 1.00 23.93 ? 175 LEU A CG 1 ATOM 1343 C CD1 . LEU A 1 175 ? -11.592 -22.769 -34.316 1.00 23.52 ? 175 LEU A CD1 1 ATOM 1344 C CD2 . LEU A 1 175 ? -14.018 -23.173 -34.953 1.00 23.97 ? 175 LEU A CD2 1 ATOM 1345 N N A GLN A 1 176 ? -12.143 -21.572 -39.650 0.50 25.17 ? 176 GLN A N 1 ATOM 1346 N N B GLN A 1 176 ? -12.173 -21.642 -39.657 0.50 25.22 ? 176 GLN A N 1 ATOM 1347 C CA A GLN A 1 176 ? -11.768 -20.675 -40.747 0.50 26.80 ? 176 GLN A CA 1 ATOM 1348 C CA B GLN A 1 176 ? -11.669 -20.893 -40.827 0.50 27.07 ? 176 GLN A CA 1 ATOM 1349 C C A GLN A 1 176 ? -13.009 -20.362 -41.595 0.50 27.79 ? 176 GLN A C 1 ATOM 1350 C C B GLN A 1 176 ? -12.767 -20.561 -41.843 0.50 27.77 ? 176 GLN A C 1 ATOM 1351 O O A GLN A 1 176 ? -13.285 -19.204 -41.956 0.50 28.41 ? 176 GLN A O 1 ATOM 1352 O O B GLN A 1 176 ? -12.681 -19.583 -42.588 0.50 28.91 ? 176 GLN A O 1 ATOM 1353 C CB A GLN A 1 176 ? -10.667 -21.307 -41.594 0.50 27.57 ? 176 GLN A CB 1 ATOM 1354 C CB B GLN A 1 176 ? -10.569 -21.727 -41.510 0.50 27.62 ? 176 GLN A CB 1 ATOM 1355 C CG A GLN A 1 176 ? -9.441 -21.793 -40.807 0.50 29.05 ? 176 GLN A CG 1 ATOM 1356 C CG B GLN A 1 176 ? -9.983 -21.098 -42.778 0.50 29.95 ? 176 GLN A CG 1 ATOM 1357 C CD A GLN A 1 176 ? -8.266 -22.100 -41.718 0.50 33.38 ? 176 GLN A CD 1 ATOM 1358 C CD B GLN A 1 176 ? -9.463 -19.693 -42.521 0.50 34.06 ? 176 GLN A CD 1 ATOM 1359 O OE1 A GLN A 1 176 ? -8.424 -22.167 -42.942 0.50 35.93 ? 176 GLN A OE1 1 ATOM 1360 O OE1 B GLN A 1 176 ? -8.581 -19.489 -41.680 0.50 33.76 ? 176 GLN A OE1 1 ATOM 1361 N NE2 A GLN A 1 176 ? -7.087 -22.293 -41.134 0.50 32.52 ? 176 GLN A NE2 1 ATOM 1362 N NE2 B GLN A 1 176 ? -10.004 -18.715 -43.250 0.50 34.94 ? 176 GLN A NE2 1 ATOM 1363 N N . TRP A 1 177 ? -13.803 -21.390 -41.869 1.00 28.67 ? 177 TRP A N 1 ATOM 1364 C CA . TRP A 1 177 ? -14.961 -21.205 -42.732 1.00 28.83 ? 177 TRP A CA 1 ATOM 1365 C C . TRP A 1 177 ? -15.850 -20.120 -42.137 1.00 28.93 ? 177 TRP A C 1 ATOM 1366 O O . TRP A 1 177 ? -16.449 -19.306 -42.854 1.00 28.53 ? 177 TRP A O 1 ATOM 1367 C CB . TRP A 1 177 ? -15.719 -22.536 -42.865 1.00 28.70 ? 177 TRP A CB 1 ATOM 1368 C CG . TRP A 1 177 ? -16.929 -22.461 -43.767 1.00 28.36 ? 177 TRP A CG 1 ATOM 1369 C CD1 . TRP A 1 177 ? -16.998 -22.887 -45.079 1.00 29.56 ? 177 TRP A CD1 1 ATOM 1370 C CD2 . TRP A 1 177 ? -18.228 -21.925 -43.451 1.00 27.04 ? 177 TRP A CD2 1 ATOM 1371 N NE1 . TRP A 1 177 ? -18.255 -22.624 -45.589 1.00 25.90 ? 177 TRP A NE1 1 ATOM 1372 C CE2 . TRP A 1 177 ? -19.029 -22.055 -44.612 1.00 26.59 ? 177 TRP A CE2 1 ATOM 1373 C CE3 . TRP A 1 177 ? -18.797 -21.350 -42.300 1.00 30.76 ? 177 TRP A CE3 1 ATOM 1374 C CZ2 . TRP A 1 177 ? -20.350 -21.630 -44.659 1.00 26.54 ? 177 TRP A CZ2 1 ATOM 1375 C CZ3 . TRP A 1 177 ? -20.132 -20.939 -42.341 1.00 30.46 ? 177 TRP A CZ3 1 ATOM 1376 C CH2 . TRP A 1 177 ? -20.888 -21.065 -43.522 1.00 30.06 ? 177 TRP A CH2 1 ATOM 1377 N N . VAL A 1 178 ? -15.992 -20.131 -40.814 1.00 28.47 ? 178 VAL A N 1 ATOM 1378 C CA . VAL A 1 178 ? -16.750 -19.080 -40.147 1.00 28.27 ? 178 VAL A CA 1 ATOM 1379 C C . VAL A 1 178 ? -16.019 -17.762 -40.341 1.00 29.26 ? 178 VAL A C 1 ATOM 1380 O O . VAL A 1 178 ? -16.632 -16.771 -40.603 1.00 30.39 ? 178 VAL A O 1 ATOM 1381 C CB . VAL A 1 178 ? -17.005 -19.398 -38.611 1.00 28.85 ? 178 VAL A CB 1 ATOM 1382 C CG1 . VAL A 1 178 ? -17.614 -18.266 -37.919 1.00 25.38 ? 178 VAL A CG1 1 ATOM 1383 C CG2 . VAL A 1 178 ? -17.926 -20.620 -38.443 1.00 24.55 ? 178 VAL A CG2 1 ATOM 1384 N N . GLN A 1 179 ? -14.701 -17.720 -40.206 1.00 30.80 ? 179 GLN A N 1 ATOM 1385 C CA . GLN A 1 179 ? -14.009 -16.444 -40.428 1.00 30.76 ? 179 GLN A CA 1 ATOM 1386 C C . GLN A 1 179 ? -14.317 -15.909 -41.842 1.00 31.88 ? 179 GLN A C 1 ATOM 1387 O O . GLN A 1 179 ? -14.767 -14.765 -42.020 1.00 31.61 ? 179 GLN A O 1 ATOM 1388 C CB . GLN A 1 179 ? -12.492 -16.583 -40.200 1.00 30.90 ? 179 GLN A CB 1 ATOM 1389 C CG . GLN A 1 179 ? -12.091 -16.643 -38.692 1.00 28.75 ? 179 GLN A CG 1 ATOM 1390 C CD . GLN A 1 179 ? -12.650 -15.467 -37.890 1.00 27.12 ? 179 GLN A CD 1 ATOM 1391 O OE1 . GLN A 1 179 ? -12.221 -14.351 -38.084 1.00 27.47 ? 179 GLN A OE1 1 ATOM 1392 N NE2 . GLN A 1 179 ? -13.608 -15.715 -37.010 1.00 24.99 ? 179 GLN A NE2 1 ATOM 1393 N N . LYS A 1 180 ? -14.092 -16.743 -42.853 1.00 32.55 ? 180 LYS A N 1 ATOM 1394 C CA . LYS A 1 180 ? -14.331 -16.332 -44.241 1.00 33.34 ? 180 LYS A CA 1 ATOM 1395 C C . LYS A 1 180 ? -15.801 -16.082 -44.628 1.00 33.54 ? 180 LYS A C 1 ATOM 1396 O O . LYS A 1 180 ? -16.067 -15.223 -45.480 1.00 34.60 ? 180 LYS A O 1 ATOM 1397 C CB . LYS A 1 180 ? -13.714 -17.325 -45.197 1.00 33.33 ? 180 LYS A CB 1 ATOM 1398 C CG . LYS A 1 180 ? -12.239 -17.552 -45.022 1.00 35.75 ? 180 LYS A CG 1 ATOM 1399 C CD . LYS A 1 180 ? -11.851 -18.648 -46.072 1.00 45.64 ? 180 LYS A CD 1 ATOM 1400 C CE . LYS A 1 180 ? -10.338 -18.856 -46.308 1.00 48.19 ? 180 LYS A CE 1 ATOM 1401 N NZ . LYS A 1 180 ? -9.794 -19.921 -45.406 1.00 52.85 ? 180 LYS A NZ 1 ATOM 1402 N N . ASN A 1 181 ? -16.757 -16.786 -44.013 1.00 31.90 ? 181 ASN A N 1 ATOM 1403 C CA . ASN A 1 181 ? -18.113 -16.795 -44.544 1.00 31.69 ? 181 ASN A CA 1 ATOM 1404 C C . ASN A 1 181 ? -19.199 -16.251 -43.657 1.00 31.58 ? 181 ASN A C 1 ATOM 1405 O O . ASN A 1 181 ? -20.295 -15.964 -44.131 1.00 31.35 ? 181 ASN A O 1 ATOM 1406 C CB . ASN A 1 181 ? -18.510 -18.215 -44.939 1.00 31.30 ? 181 ASN A CB 1 ATOM 1407 C CG . ASN A 1 181 ? -17.648 -18.757 -46.066 1.00 34.45 ? 181 ASN A CG 1 ATOM 1408 O OD1 . ASN A 1 181 ? -17.756 -18.308 -47.214 1.00 35.16 ? 181 ASN A OD1 1 ATOM 1409 N ND2 . ASN A 1 181 ? -16.787 -19.719 -45.754 1.00 31.52 ? 181 ASN A ND2 1 ATOM 1410 N N . ILE A 1 182 ? -18.954 -16.131 -42.366 1.00 30.50 ? 182 ILE A N 1 ATOM 1411 C CA . ILE A 1 182 ? -20.113 -15.821 -41.526 1.00 31.35 ? 182 ILE A CA 1 ATOM 1412 C C . ILE A 1 182 ? -20.687 -14.392 -41.669 1.00 31.60 ? 182 ILE A C 1 ATOM 1413 O O . ILE A 1 182 ? -21.849 -14.167 -41.352 1.00 31.37 ? 182 ILE A O 1 ATOM 1414 C CB . ILE A 1 182 ? -19.886 -16.191 -40.042 1.00 31.73 ? 182 ILE A CB 1 ATOM 1415 C CG1 . ILE A 1 182 ? -21.225 -16.506 -39.365 1.00 30.51 ? 182 ILE A CG1 1 ATOM 1416 C CG2 . ILE A 1 182 ? -19.072 -15.081 -39.353 1.00 30.02 ? 182 ILE A CG2 1 ATOM 1417 C CD1 . ILE A 1 182 ? -21.728 -17.908 -39.625 1.00 28.59 ? 182 ILE A CD1 1 ATOM 1418 N N . ALA A 1 183 ? -19.901 -13.421 -42.134 1.00 32.45 ? 183 ALA A N 1 ATOM 1419 C CA . ALA A 1 183 ? -20.461 -12.072 -42.350 1.00 32.59 ? 183 ALA A CA 1 ATOM 1420 C C . ALA A 1 183 ? -21.610 -12.130 -43.341 1.00 33.46 ? 183 ALA A C 1 ATOM 1421 O O . ALA A 1 183 ? -22.625 -11.462 -43.167 1.00 34.43 ? 183 ALA A O 1 ATOM 1422 C CB . ALA A 1 183 ? -19.378 -11.112 -42.835 1.00 32.62 ? 183 ALA A CB 1 ATOM 1423 N N . ALA A 1 184 ? -21.474 -12.971 -44.359 1.00 34.05 ? 184 ALA A N 1 ATOM 1424 C CA . ALA A 1 184 ? -22.560 -13.212 -45.351 1.00 34.34 ? 184 ALA A CA 1 ATOM 1425 C C . ALA A 1 184 ? -23.923 -13.635 -44.771 1.00 34.69 ? 184 ALA A C 1 ATOM 1426 O O . ALA A 1 184 ? -24.990 -13.259 -45.303 1.00 35.78 ? 184 ALA A O 1 ATOM 1427 C CB . ALA A 1 184 ? -22.089 -14.220 -46.391 1.00 34.59 ? 184 ALA A CB 1 ATOM 1428 N N . PHE A 1 185 ? -23.903 -14.407 -43.676 1.00 33.80 ? 185 PHE A N 1 ATOM 1429 C CA . PHE A 1 185 ? -25.121 -14.790 -42.931 1.00 31.98 ? 185 PHE A CA 1 ATOM 1430 C C . PHE A 1 185 ? -25.523 -13.745 -41.889 1.00 32.39 ? 185 PHE A C 1 ATOM 1431 O O . PHE A 1 185 ? -26.491 -13.923 -41.180 1.00 32.28 ? 185 PHE A O 1 ATOM 1432 C CB . PHE A 1 185 ? -24.864 -16.106 -42.211 1.00 32.29 ? 185 PHE A CB 1 ATOM 1433 C CG . PHE A 1 185 ? -24.531 -17.254 -43.147 1.00 31.26 ? 185 PHE A CG 1 ATOM 1434 C CD1 . PHE A 1 185 ? -23.319 -17.288 -43.800 1.00 26.15 ? 185 PHE A CD1 1 ATOM 1435 C CD2 . PHE A 1 185 ? -25.482 -18.246 -43.412 1.00 29.86 ? 185 PHE A CD2 1 ATOM 1436 C CE1 . PHE A 1 185 ? -23.015 -18.334 -44.672 1.00 32.81 ? 185 PHE A CE1 1 ATOM 1437 C CE2 . PHE A 1 185 ? -25.201 -19.296 -44.303 1.00 30.25 ? 185 PHE A CE2 1 ATOM 1438 C CZ . PHE A 1 185 ? -23.977 -19.353 -44.928 1.00 31.67 ? 185 PHE A CZ 1 ATOM 1439 N N . GLY A 1 186 ? -24.765 -12.658 -41.787 1.00 32.52 ? 186 GLY A N 1 ATOM 1440 C CA . GLY A 1 186 ? -25.048 -11.623 -40.778 1.00 32.52 ? 186 GLY A CA 1 ATOM 1441 C C . GLY A 1 186 ? -24.240 -11.722 -39.486 1.00 33.02 ? 186 GLY A C 1 ATOM 1442 O O . GLY A 1 186 ? -24.634 -11.145 -38.445 1.00 32.66 ? 186 GLY A O 1 ATOM 1443 N N . GLY A 1 187 ? -23.092 -12.407 -39.546 1.00 32.21 ? 187 GLY A N 1 ATOM 1444 C CA . GLY A 1 187 ? -22.336 -12.694 -38.341 1.00 32.81 ? 187 GLY A CA 1 ATOM 1445 C C . GLY A 1 187 ? -21.102 -11.850 -38.218 1.00 33.06 ? 187 GLY A C 1 ATOM 1446 O O . GLY A 1 187 ? -20.561 -11.413 -39.192 1.00 33.51 ? 187 GLY A O 1 ATOM 1447 N N . ASN A 1 188 ? -20.653 -11.619 -36.993 1.00 33.25 ? 188 ASN A N 1 ATOM 1448 C CA . ASN A 1 188 ? -19.409 -10.929 -36.758 1.00 31.93 ? 188 ASN A CA 1 ATOM 1449 C C . ASN A 1 188 ? -18.251 -11.878 -36.511 1.00 31.74 ? 188 ASN A C 1 ATOM 1450 O O . ASN A 1 188 ? -18.098 -12.386 -35.411 1.00 30.77 ? 188 ASN A O 1 ATOM 1451 C CB . ASN A 1 188 ? -19.587 -10.075 -35.519 1.00 31.85 ? 188 ASN A CB 1 ATOM 1452 C CG . ASN A 1 188 ? -18.425 -9.162 -35.290 1.00 31.53 ? 188 ASN A CG 1 ATOM 1453 O OD1 . ASN A 1 188 ? -17.462 -9.155 -36.052 1.00 29.70 ? 188 ASN A OD1 1 ATOM 1454 N ND2 . ASN A 1 188 ? -18.509 -8.376 -34.252 1.00 29.84 ? 188 ASN A ND2 1 ATOM 1455 N N . PRO A 1 189 ? -17.391 -12.077 -37.515 1.00 31.73 ? 189 PRO A N 1 ATOM 1456 C CA . PRO A 1 189 ? -16.249 -12.967 -37.321 1.00 31.20 ? 189 PRO A CA 1 ATOM 1457 C C . PRO A 1 189 ? -15.265 -12.499 -36.209 1.00 31.60 ? 189 PRO A C 1 ATOM 1458 O O . PRO A 1 189 ? -14.422 -13.295 -35.756 1.00 32.39 ? 189 PRO A O 1 ATOM 1459 C CB . PRO A 1 189 ? -15.557 -12.940 -38.693 1.00 31.99 ? 189 PRO A CB 1 ATOM 1460 C CG . PRO A 1 189 ? -15.930 -11.654 -39.290 1.00 31.23 ? 189 PRO A CG 1 ATOM 1461 C CD . PRO A 1 189 ? -17.267 -11.249 -38.726 1.00 30.75 ? 189 PRO A CD 1 ATOM 1462 N N . LYS A 1 190 ? -15.369 -11.231 -35.790 1.00 30.29 ? 190 LYS A N 1 ATOM 1463 C CA . LYS A 1 190 ? -14.556 -10.669 -34.720 1.00 29.11 ? 190 LYS A CA 1 ATOM 1464 C C . LYS A 1 190 ? -15.176 -10.946 -33.341 1.00 27.59 ? 190 LYS A C 1 ATOM 1465 O O . LYS A 1 190 ? -14.557 -10.654 -32.339 1.00 26.24 ? 190 LYS A O 1 ATOM 1466 C CB . LYS A 1 190 ? -14.436 -9.156 -34.893 1.00 29.61 ? 190 LYS A CB 1 ATOM 1467 C CG . LYS A 1 190 ? -13.309 -8.775 -35.799 1.00 32.73 ? 190 LYS A CG 1 ATOM 1468 C CD . LYS A 1 190 ? -13.328 -7.285 -36.118 1.00 40.11 ? 190 LYS A CD 1 ATOM 1469 C CE . LYS A 1 190 ? -12.017 -6.866 -36.792 1.00 44.11 ? 190 LYS A CE 1 ATOM 1470 N NZ . LYS A 1 190 ? -12.101 -5.454 -37.281 1.00 48.98 ? 190 LYS A NZ 1 ATOM 1471 N N . SER A 1 191 ? -16.394 -11.480 -33.299 1.00 24.64 ? 191 SER A N 1 ATOM 1472 C CA . SER A 1 191 ? -16.990 -11.881 -32.022 1.00 23.72 ? 191 SER A CA 1 ATOM 1473 C C . SER A 1 191 ? -17.412 -13.339 -32.155 1.00 23.26 ? 191 SER A C 1 ATOM 1474 O O . SER A 1 191 ? -18.560 -13.612 -32.382 1.00 25.14 ? 191 SER A O 1 ATOM 1475 C CB . SER A 1 191 ? -18.160 -11.006 -31.711 1.00 22.11 ? 191 SER A CB 1 ATOM 1476 O OG . SER A 1 191 ? -18.800 -11.255 -30.440 1.00 24.35 ? 191 SER A OG 1 ATOM 1477 N N . VAL A 1 192 ? -16.471 -14.267 -31.976 1.00 22.48 ? 192 VAL A N 1 ATOM 1478 C CA . VAL A 1 192 ? -16.733 -15.674 -32.058 1.00 21.80 ? 192 VAL A CA 1 ATOM 1479 C C . VAL A 1 192 ? -16.355 -16.359 -30.756 1.00 21.15 ? 192 VAL A C 1 ATOM 1480 O O . VAL A 1 192 ? -15.215 -16.267 -30.310 1.00 19.68 ? 192 VAL A O 1 ATOM 1481 C CB . VAL A 1 192 ? -15.954 -16.297 -33.248 1.00 22.72 ? 192 VAL A CB 1 ATOM 1482 C CG1 . VAL A 1 192 ? -15.979 -17.833 -33.177 1.00 23.83 ? 192 VAL A CG1 1 ATOM 1483 C CG2 . VAL A 1 192 ? -16.594 -15.840 -34.519 1.00 21.94 ? 192 VAL A CG2 1 ATOM 1484 N N . THR A 1 193 ? -17.314 -17.050 -30.137 1.00 21.14 ? 193 THR A N 1 ATOM 1485 C CA . THR A 1 193 ? -16.992 -17.806 -28.937 1.00 20.24 ? 193 THR A CA 1 ATOM 1486 C C . THR A 1 193 ? -17.071 -19.297 -29.161 1.00 20.26 ? 193 THR A C 1 ATOM 1487 O O . THR A 1 193 ? -18.076 -19.763 -29.659 1.00 20.43 ? 193 THR A O 1 ATOM 1488 C CB . THR A 1 193 ? -18.007 -17.465 -27.846 1.00 20.56 ? 193 THR A CB 1 ATOM 1489 O OG1 . THR A 1 193 ? -17.770 -16.113 -27.447 1.00 21.67 ? 193 THR A OG1 1 ATOM 1490 C CG2 . THR A 1 193 ? -17.808 -18.377 -26.641 1.00 16.50 ? 193 THR A CG2 1 ATOM 1491 N N . LEU A 1 194 ? -16.030 -20.059 -28.808 1.00 20.66 ? 194 LEU A N 1 ATOM 1492 C CA . LEU A 1 194 ? -16.156 -21.519 -28.948 1.00 20.50 ? 194 LEU A CA 1 ATOM 1493 C C . LEU A 1 194 ? -16.752 -22.030 -27.662 1.00 21.05 ? 194 LEU A C 1 ATOM 1494 O O . LEU A 1 194 ? -16.388 -21.489 -26.597 1.00 20.37 ? 194 LEU A O 1 ATOM 1495 C CB . LEU A 1 194 ? -14.792 -22.188 -29.146 1.00 19.33 ? 194 LEU A CB 1 ATOM 1496 C CG . LEU A 1 194 ? -13.808 -21.598 -30.156 1.00 20.00 ? 194 LEU A CG 1 ATOM 1497 C CD1 . LEU A 1 194 ? -12.502 -22.388 -30.193 1.00 15.89 ? 194 LEU A CD1 1 ATOM 1498 C CD2 . LEU A 1 194 ? -14.436 -21.506 -31.571 1.00 15.37 ? 194 LEU A CD2 1 ATOM 1499 N N . PHE A 1 195 ? -17.624 -23.065 -27.738 1.00 20.88 ? 195 PHE A N 1 ATOM 1500 C CA . PHE A 1 195 ? -18.127 -23.762 -26.564 1.00 20.32 ? 195 PHE A CA 1 ATOM 1501 C C . PHE A 1 195 ? -18.214 -25.216 -26.860 1.00 22.80 ? 195 PHE A C 1 ATOM 1502 O O . PHE A 1 195 ? -18.344 -25.582 -28.037 1.00 22.62 ? 195 PHE A O 1 ATOM 1503 C CB . PHE A 1 195 ? -19.400 -23.128 -25.910 1.00 20.94 ? 195 PHE A CB 1 ATOM 1504 C CG . PHE A 1 195 ? -20.694 -23.211 -26.693 1.00 19.35 ? 195 PHE A CG 1 ATOM 1505 C CD1 . PHE A 1 195 ? -20.753 -22.961 -28.052 1.00 21.12 ? 195 PHE A CD1 1 ATOM 1506 C CD2 . PHE A 1 195 ? -21.887 -23.507 -26.023 1.00 16.12 ? 195 PHE A CD2 1 ATOM 1507 C CE1 . PHE A 1 195 ? -21.973 -23.067 -28.720 1.00 18.19 ? 195 PHE A CE1 1 ATOM 1508 C CE2 . PHE A 1 195 ? -23.055 -23.592 -26.654 1.00 20.01 ? 195 PHE A CE2 1 ATOM 1509 C CZ . PHE A 1 195 ? -23.124 -23.357 -28.037 1.00 16.88 ? 195 PHE A CZ 1 ATOM 1510 N N . GLY A 1 196 ? -18.031 -26.066 -25.832 1.00 22.57 ? 196 GLY A N 1 ATOM 1511 C CA . GLY A 1 196 ? -17.916 -27.484 -26.096 1.00 22.23 ? 196 GLY A CA 1 ATOM 1512 C C . GLY A 1 196 ? -18.066 -28.192 -24.790 1.00 22.07 ? 196 GLY A C 1 ATOM 1513 O O . GLY A 1 196 ? -17.889 -27.572 -23.736 1.00 22.66 ? 196 GLY A O 1 ATOM 1514 N N . GLU A 1 197 ? -18.436 -29.469 -24.821 1.00 20.71 ? 197 GLU A N 1 ATOM 1515 C CA . GLU A 1 197 ? -18.571 -30.237 -23.591 1.00 19.20 ? 197 GLU A CA 1 ATOM 1516 C C . GLU A 1 197 ? -17.711 -31.488 -23.615 1.00 20.46 ? 197 GLU A C 1 ATOM 1517 O O . GLU A 1 197 ? -17.503 -32.121 -24.685 1.00 19.98 ? 197 GLU A O 1 ATOM 1518 C CB . GLU A 1 197 ? -20.034 -30.555 -23.243 1.00 19.34 ? 197 GLU A CB 1 ATOM 1519 C CG . GLU A 1 197 ? -20.253 -31.292 -21.891 1.00 20.14 ? 197 GLU A CG 1 ATOM 1520 C CD . GLU A 1 197 ? -20.333 -32.792 -22.030 1.00 23.63 ? 197 GLU A CD 1 ATOM 1521 O OE1 . GLU A 1 197 ? -20.096 -33.223 -23.184 1.00 21.56 ? 197 GLU A OE1 1 ATOM 1522 O OE2 . GLU A 1 197 ? -20.632 -33.529 -21.026 1.00 22.57 ? 197 GLU A OE2 1 ATOM 1523 N N . SER A 1 198 ? -17.146 -31.833 -22.442 1.00 20.13 ? 198 SER A N 1 ATOM 1524 C CA . SER A 1 198 ? -16.273 -33.009 -22.339 1.00 21.38 ? 198 SER A CA 1 ATOM 1525 C C . SER A 1 198 ? -15.150 -32.966 -23.402 1.00 21.20 ? 198 SER A C 1 ATOM 1526 O O . SER A 1 198 ? -14.369 -32.014 -23.462 1.00 22.93 ? 198 SER A O 1 ATOM 1527 C CB . SER A 1 198 ? -17.127 -34.266 -22.487 1.00 20.72 ? 198 SER A CB 1 ATOM 1528 O OG . SER A 1 198 ? -16.488 -35.400 -21.914 1.00 26.78 ? 198 SER A OG 1 ATOM 1529 N N . ALA A 1 199 ? -15.039 -33.964 -24.267 1.00 20.29 ? 199 ALA A N 1 ATOM 1530 C CA . ALA A 1 199 ? -13.991 -33.909 -25.290 1.00 18.51 ? 199 ALA A CA 1 ATOM 1531 C C . ALA A 1 199 ? -14.137 -32.670 -26.167 1.00 19.15 ? 199 ALA A C 1 ATOM 1532 O O . ALA A 1 199 ? -13.127 -32.159 -26.770 1.00 19.61 ? 199 ALA A O 1 ATOM 1533 C CB . ALA A 1 199 ? -14.032 -35.199 -26.166 1.00 19.99 ? 199 ALA A CB 1 ATOM 1534 N N . GLY A 1 200 ? -15.382 -32.170 -26.291 1.00 17.88 ? 200 GLY A N 1 ATOM 1535 C CA . GLY A 1 200 ? -15.549 -30.938 -27.056 1.00 18.22 ? 200 GLY A CA 1 ATOM 1536 C C . GLY A 1 200 ? -14.884 -29.769 -26.293 1.00 18.67 ? 200 GLY A C 1 ATOM 1537 O O . GLY A 1 200 ? -14.343 -28.809 -26.876 1.00 18.30 ? 200 GLY A O 1 ATOM 1538 N N . ALA A 1 201 ? -14.933 -29.844 -24.978 1.00 18.65 ? 201 ALA A N 1 ATOM 1539 C CA . ALA A 1 201 ? -14.299 -28.774 -24.135 1.00 20.09 ? 201 ALA A CA 1 ATOM 1540 C C . ALA A 1 201 ? -12.825 -28.884 -24.175 1.00 20.03 ? 201 ALA A C 1 ATOM 1541 O O . ALA A 1 201 ? -12.130 -27.877 -24.270 1.00 20.12 ? 201 ALA A O 1 ATOM 1542 C CB . ALA A 1 201 ? -14.784 -28.862 -22.658 1.00 16.27 ? 201 ALA A CB 1 ATOM 1543 N N . ALA A 1 202 ? -12.330 -30.116 -24.020 1.00 21.71 ? 202 ALA A N 1 ATOM 1544 C CA . ALA A 1 202 ? -10.917 -30.358 -24.154 1.00 21.03 ? 202 ALA A CA 1 ATOM 1545 C C . ALA A 1 202 ? -10.452 -29.776 -25.497 1.00 21.64 ? 202 ALA A C 1 ATOM 1546 O O . ALA A 1 202 ? -9.361 -29.151 -25.590 1.00 21.36 ? 202 ALA A O 1 ATOM 1547 C CB . ALA A 1 202 ? -10.637 -31.831 -24.094 1.00 21.27 ? 202 ALA A CB 1 ATOM 1548 N N . SER A 1 203 ? -11.260 -29.942 -26.543 1.00 20.42 ? 203 SER A N 1 ATOM 1549 C CA . SER A 1 203 ? -10.865 -29.455 -27.860 1.00 19.56 ? 203 SER A CA 1 ATOM 1550 C C . SER A 1 203 ? -10.813 -27.928 -27.757 1.00 19.10 ? 203 SER A C 1 ATOM 1551 O O . SER A 1 203 ? -9.874 -27.313 -28.174 1.00 17.60 ? 203 SER A O 1 ATOM 1552 C CB . SER A 1 203 ? -11.920 -29.850 -28.931 1.00 20.33 ? 203 SER A CB 1 ATOM 1553 O OG . SER A 1 203 ? -11.885 -31.249 -29.224 1.00 24.14 ? 203 SER A OG 1 ATOM 1554 N N . VAL A 1 204 ? -11.829 -27.301 -27.178 1.00 19.02 ? 204 VAL A N 1 ATOM 1555 C CA . VAL A 1 204 ? -11.792 -25.829 -27.022 1.00 19.23 ? 204 VAL A CA 1 ATOM 1556 C C . VAL A 1 204 ? -10.476 -25.432 -26.313 1.00 19.67 ? 204 VAL A C 1 ATOM 1557 O O . VAL A 1 204 ? -9.814 -24.493 -26.683 1.00 19.65 ? 204 VAL A O 1 ATOM 1558 C CB . VAL A 1 204 ? -13.011 -25.299 -26.172 1.00 20.53 ? 204 VAL A CB 1 ATOM 1559 C CG1 . VAL A 1 204 ? -12.797 -23.798 -25.645 1.00 18.01 ? 204 VAL A CG1 1 ATOM 1560 C CG2 . VAL A 1 204 ? -14.343 -25.439 -26.945 1.00 20.52 ? 204 VAL A CG2 1 ATOM 1561 N N . SER A 1 205 ? -10.082 -26.184 -25.299 1.00 19.10 ? 205 SER A N 1 ATOM 1562 C CA . SER A 1 205 ? -8.914 -25.754 -24.506 1.00 20.47 ? 205 SER A CA 1 ATOM 1563 C C . SER A 1 205 ? -7.621 -25.849 -25.340 1.00 21.26 ? 205 SER A C 1 ATOM 1564 O O . SER A 1 205 ? -6.671 -25.090 -25.104 1.00 22.44 ? 205 SER A O 1 ATOM 1565 C CB . SER A 1 205 ? -8.826 -26.557 -23.227 1.00 17.98 ? 205 SER A CB 1 ATOM 1566 O OG . SER A 1 205 ? -8.392 -27.868 -23.516 1.00 18.27 ? 205 SER A OG 1 ATOM 1567 N N . LEU A 1 206 ? -7.607 -26.736 -26.334 1.00 20.42 ? 206 LEU A N 1 ATOM 1568 C CA . LEU A 1 206 ? -6.417 -26.927 -27.196 1.00 21.46 ? 206 LEU A CA 1 ATOM 1569 C C . LEU A 1 206 ? -6.412 -25.923 -28.324 1.00 21.93 ? 206 LEU A C 1 ATOM 1570 O O . LEU A 1 206 ? -5.350 -25.570 -28.837 1.00 22.64 ? 206 LEU A O 1 ATOM 1571 C CB . LEU A 1 206 ? -6.390 -28.367 -27.783 1.00 21.35 ? 206 LEU A CB 1 ATOM 1572 C CG . LEU A 1 206 ? -6.113 -29.484 -26.745 1.00 23.72 ? 206 LEU A CG 1 ATOM 1573 C CD1 . LEU A 1 206 ? -6.451 -30.876 -27.277 1.00 23.51 ? 206 LEU A CD1 1 ATOM 1574 C CD2 . LEU A 1 206 ? -4.675 -29.434 -26.096 1.00 20.14 ? 206 LEU A CD2 1 ATOM 1575 N N . HIS A 1 207 ? -7.588 -25.456 -28.737 1.00 21.42 ? 207 HIS A N 1 ATOM 1576 C CA . HIS A 1 207 ? -7.592 -24.363 -29.685 1.00 21.76 ? 207 HIS A CA 1 ATOM 1577 C C . HIS A 1 207 ? -7.036 -23.093 -28.979 1.00 23.17 ? 207 HIS A C 1 ATOM 1578 O O . HIS A 1 207 ? -6.436 -22.254 -29.633 1.00 23.12 ? 207 HIS A O 1 ATOM 1579 C CB . HIS A 1 207 ? -8.997 -24.110 -30.210 1.00 21.82 ? 207 HIS A CB 1 ATOM 1580 C CG . HIS A 1 207 ? -9.467 -25.117 -31.237 1.00 24.08 ? 207 HIS A CG 1 ATOM 1581 N ND1 . HIS A 1 207 ? -8.996 -25.147 -32.538 1.00 20.68 ? 207 HIS A ND1 1 ATOM 1582 C CD2 . HIS A 1 207 ? -10.394 -26.102 -31.152 1.00 21.01 ? 207 HIS A CD2 1 ATOM 1583 C CE1 . HIS A 1 207 ? -9.616 -26.112 -33.206 1.00 24.76 ? 207 HIS A CE1 1 ATOM 1584 N NE2 . HIS A 1 207 ? -10.465 -26.715 -32.381 1.00 20.94 ? 207 HIS A NE2 1 ATOM 1585 N N . LEU A 1 208 ? -7.242 -22.950 -27.663 1.00 23.04 ? 208 LEU A N 1 ATOM 1586 C CA . LEU A 1 208 ? -6.580 -21.875 -26.886 1.00 23.69 ? 208 LEU A CA 1 ATOM 1587 C C . LEU A 1 208 ? -5.039 -21.988 -26.938 1.00 24.58 ? 208 LEU A C 1 ATOM 1588 O O . LEU A 1 208 ? -4.330 -20.995 -26.910 1.00 27.20 ? 208 LEU A O 1 ATOM 1589 C CB . LEU A 1 208 ? -7.044 -21.881 -25.410 1.00 21.94 ? 208 LEU A CB 1 ATOM 1590 C CG . LEU A 1 208 ? -8.409 -21.250 -25.061 1.00 21.89 ? 208 LEU A CG 1 ATOM 1591 C CD1 . LEU A 1 208 ? -8.825 -21.615 -23.579 1.00 18.61 ? 208 LEU A CD1 1 ATOM 1592 C CD2 . LEU A 1 208 ? -8.452 -19.696 -25.230 1.00 15.39 ? 208 LEU A CD2 1 ATOM 1593 N N . LEU A 1 209 ? -4.505 -23.193 -27.016 1.00 25.88 ? 209 LEU A N 1 ATOM 1594 C CA . LEU A 1 209 ? -3.070 -23.363 -27.087 1.00 26.40 ? 209 LEU A CA 1 ATOM 1595 C C . LEU A 1 209 ? -2.499 -23.403 -28.503 1.00 27.26 ? 209 LEU A C 1 ATOM 1596 O O . LEU A 1 209 ? -1.286 -23.379 -28.682 1.00 29.31 ? 209 LEU A O 1 ATOM 1597 C CB . LEU A 1 209 ? -2.638 -24.635 -26.383 1.00 26.37 ? 209 LEU A CB 1 ATOM 1598 C CG . LEU A 1 209 ? -3.052 -24.881 -24.950 1.00 28.73 ? 209 LEU A CG 1 ATOM 1599 C CD1 . LEU A 1 209 ? -2.179 -25.907 -24.255 1.00 28.91 ? 209 LEU A CD1 1 ATOM 1600 C CD2 . LEU A 1 209 ? -3.202 -23.685 -24.126 1.00 26.23 ? 209 LEU A CD2 1 ATOM 1601 N N . SER A 1 210 ? -3.344 -23.473 -29.505 1.00 27.92 ? 210 SER A N 1 ATOM 1602 C CA . SER A 1 210 ? -2.857 -23.708 -30.845 1.00 27.94 ? 210 SER A CA 1 ATOM 1603 C C . SER A 1 210 ? -2.604 -22.420 -31.608 1.00 29.02 ? 210 SER A C 1 ATOM 1604 O O . SER A 1 210 ? -3.530 -21.681 -31.965 1.00 27.02 ? 210 SER A O 1 ATOM 1605 C CB . SER A 1 210 ? -3.817 -24.588 -31.658 1.00 28.56 ? 210 SER A CB 1 ATOM 1606 O OG . SER A 1 210 ? -3.211 -24.831 -32.960 1.00 26.63 ? 210 SER A OG 1 ATOM 1607 N N . PRO A 1 211 ? -1.340 -22.177 -31.948 1.00 30.62 ? 211 PRO A N 1 ATOM 1608 C CA . PRO A 1 211 ? -1.092 -20.968 -32.703 1.00 31.08 ? 211 PRO A CA 1 ATOM 1609 C C . PRO A 1 211 ? -1.986 -20.837 -33.960 1.00 30.56 ? 211 PRO A C 1 ATOM 1610 O O . PRO A 1 211 ? -2.416 -19.742 -34.254 1.00 32.30 ? 211 PRO A O 1 ATOM 1611 C CB . PRO A 1 211 ? 0.408 -21.034 -33.014 1.00 30.92 ? 211 PRO A CB 1 ATOM 1612 C CG . PRO A 1 211 ? 0.744 -22.498 -32.879 1.00 33.56 ? 211 PRO A CG 1 ATOM 1613 C CD . PRO A 1 211 ? -0.138 -23.009 -31.777 1.00 31.66 ? 211 PRO A CD 1 ATOM 1614 N N . GLY A 1 212 ? -2.334 -21.913 -34.659 1.00 30.36 ? 212 GLY A N 1 ATOM 1615 C CA . GLY A 1 212 ? -3.138 -21.756 -35.875 1.00 28.06 ? 212 GLY A CA 1 ATOM 1616 C C . GLY A 1 212 ? -4.598 -21.441 -35.663 1.00 28.82 ? 212 GLY A C 1 ATOM 1617 O O . GLY A 1 212 ? -5.301 -21.091 -36.595 1.00 28.52 ? 212 GLY A O 1 ATOM 1618 N N . SER A 1 213 ? -5.098 -21.637 -34.445 1.00 28.47 ? 213 SER A N 1 ATOM 1619 C CA . SER A 1 213 ? -6.456 -21.245 -34.065 1.00 28.22 ? 213 SER A CA 1 ATOM 1620 C C . SER A 1 213 ? -6.539 -19.839 -33.428 1.00 29.34 ? 213 SER A C 1 ATOM 1621 O O . SER A 1 213 ? -7.627 -19.315 -33.194 1.00 29.81 ? 213 SER A O 1 ATOM 1622 C CB . SER A 1 213 ? -7.019 -22.296 -33.068 1.00 28.37 ? 213 SER A CB 1 ATOM 1623 O OG . SER A 1 213 ? -7.071 -23.602 -33.687 1.00 27.39 ? 213 SER A OG 1 ATOM 1624 N N . HIS A 1 214 ? -5.398 -19.244 -33.109 1.00 30.35 ? 214 HIS A N 1 ATOM 1625 C CA . HIS A 1 214 ? -5.365 -18.016 -32.302 1.00 31.14 ? 214 HIS A CA 1 ATOM 1626 C C . HIS A 1 214 ? -6.311 -16.971 -32.870 1.00 30.79 ? 214 HIS A C 1 ATOM 1627 O O . HIS A 1 214 ? -7.061 -16.304 -32.119 1.00 30.97 ? 214 HIS A O 1 ATOM 1628 C CB . HIS A 1 214 ? -3.916 -17.466 -32.206 1.00 33.02 ? 214 HIS A CB 1 ATOM 1629 C CG . HIS A 1 214 ? -3.741 -16.308 -31.252 1.00 36.48 ? 214 HIS A CG 1 ATOM 1630 N ND1 . HIS A 1 214 ? -4.029 -14.996 -31.590 1.00 40.69 ? 214 HIS A ND1 1 ATOM 1631 C CD2 . HIS A 1 214 ? -3.258 -16.261 -29.983 1.00 38.30 ? 214 HIS A CD2 1 ATOM 1632 C CE1 . HIS A 1 214 ? -3.775 -14.205 -30.556 1.00 39.64 ? 214 HIS A CE1 1 ATOM 1633 N NE2 . HIS A 1 214 ? -3.291 -14.946 -29.573 1.00 36.01 ? 214 HIS A NE2 1 ATOM 1634 N N . SER A 1 215 ? -6.307 -16.817 -34.194 1.00 29.15 ? 215 SER A N 1 ATOM 1635 C CA . SER A 1 215 ? -7.028 -15.694 -34.784 1.00 28.73 ? 215 SER A CA 1 ATOM 1636 C C . SER A 1 215 ? -8.371 -16.119 -35.352 1.00 27.46 ? 215 SER A C 1 ATOM 1637 O O . SER A 1 215 ? -8.981 -15.339 -36.077 1.00 27.88 ? 215 SER A O 1 ATOM 1638 C CB . SER A 1 215 ? -6.196 -15.099 -35.934 1.00 30.30 ? 215 SER A CB 1 ATOM 1639 O OG . SER A 1 215 ? -6.228 -16.016 -37.048 1.00 33.55 ? 215 SER A OG 1 ATOM 1640 N N . LEU A 1 216 ? -8.815 -17.357 -35.059 1.00 25.00 ? 216 LEU A N 1 ATOM 1641 C CA . LEU A 1 216 ? -10.094 -17.883 -35.566 1.00 23.39 ? 216 LEU A CA 1 ATOM 1642 C C . LEU A 1 216 ? -11.203 -17.754 -34.530 1.00 23.92 ? 216 LEU A C 1 ATOM 1643 O O . LEU A 1 216 ? -12.336 -18.241 -34.739 1.00 23.46 ? 216 LEU A O 1 ATOM 1644 C CB . LEU A 1 216 ? -9.922 -19.341 -35.953 1.00 22.75 ? 216 LEU A CB 1 ATOM 1645 C CG . LEU A 1 216 ? -8.736 -19.627 -36.875 1.00 21.12 ? 216 LEU A CG 1 ATOM 1646 C CD1 . LEU A 1 216 ? -8.738 -21.103 -37.337 1.00 22.11 ? 216 LEU A CD1 1 ATOM 1647 C CD2 . LEU A 1 216 ? -8.805 -18.714 -38.069 1.00 22.27 ? 216 LEU A CD2 1 ATOM 1648 N N . PHE A 1 217 ? -10.914 -17.109 -33.391 1.00 21.91 ? 217 PHE A N 1 ATOM 1649 C CA . PHE A 1 217 ? -12.003 -16.944 -32.394 1.00 20.89 ? 217 PHE A CA 1 ATOM 1650 C C . PHE A 1 217 ? -11.664 -15.950 -31.298 1.00 21.48 ? 217 PHE A C 1 ATOM 1651 O O . PHE A 1 217 ? -10.495 -15.579 -31.151 1.00 22.41 ? 217 PHE A O 1 ATOM 1652 C CB . PHE A 1 217 ? -12.374 -18.295 -31.776 1.00 19.83 ? 217 PHE A CB 1 ATOM 1653 C CG . PHE A 1 217 ? -11.320 -18.880 -30.853 1.00 17.93 ? 217 PHE A CG 1 ATOM 1654 C CD1 . PHE A 1 217 ? -10.164 -19.464 -31.353 1.00 19.09 ? 217 PHE A CD1 1 ATOM 1655 C CD2 . PHE A 1 217 ? -11.518 -18.885 -29.467 1.00 17.46 ? 217 PHE A CD2 1 ATOM 1656 C CE1 . PHE A 1 217 ? -9.239 -20.009 -30.517 1.00 15.82 ? 217 PHE A CE1 1 ATOM 1657 C CE2 . PHE A 1 217 ? -10.592 -19.420 -28.621 1.00 16.53 ? 217 PHE A CE2 1 ATOM 1658 C CZ . PHE A 1 217 ? -9.466 -20.005 -29.142 1.00 18.40 ? 217 PHE A CZ 1 ATOM 1659 N N . THR A 1 218 ? -12.672 -15.512 -30.550 1.00 21.69 ? 218 THR A N 1 ATOM 1660 C CA . THR A 1 218 ? -12.478 -14.471 -29.533 1.00 22.51 ? 218 THR A CA 1 ATOM 1661 C C . THR A 1 218 ? -12.393 -15.037 -28.078 1.00 23.40 ? 218 THR A C 1 ATOM 1662 O O . THR A 1 218 ? -11.423 -14.771 -27.344 1.00 24.40 ? 218 THR A O 1 ATOM 1663 C CB . THR A 1 218 ? -13.635 -13.497 -29.593 1.00 23.49 ? 218 THR A CB 1 ATOM 1664 O OG1 . THR A 1 218 ? -13.832 -13.109 -30.952 1.00 24.83 ? 218 THR A OG1 1 ATOM 1665 C CG2 . THR A 1 218 ? -13.341 -12.208 -28.736 1.00 19.88 ? 218 THR A CG2 1 ATOM 1666 N N . ARG A 1 219 ? -13.403 -15.815 -27.666 1.00 21.68 ? 219 ARG A N 1 ATOM 1667 C CA . ARG A 1 219 ? -13.497 -16.286 -26.274 1.00 23.13 ? 219 ARG A CA 1 ATOM 1668 C C . ARG A 1 219 ? -13.787 -17.797 -26.266 1.00 22.35 ? 219 ARG A C 1 ATOM 1669 O O . ARG A 1 219 ? -14.110 -18.357 -27.309 1.00 22.27 ? 219 ARG A O 1 ATOM 1670 C CB . ARG A 1 219 ? -14.661 -15.556 -25.589 1.00 23.29 ? 219 ARG A CB 1 ATOM 1671 C CG . ARG A 1 219 ? -14.232 -14.283 -25.005 1.00 29.40 ? 219 ARG A CG 1 ATOM 1672 C CD . ARG A 1 219 ? -15.282 -13.658 -24.168 1.00 29.48 ? 219 ARG A CD 1 ATOM 1673 N NE . ARG A 1 219 ? -16.055 -12.852 -25.054 1.00 32.09 ? 219 ARG A NE 1 ATOM 1674 C CZ . ARG A 1 219 ? -15.651 -11.678 -25.478 1.00 30.46 ? 219 ARG A CZ 1 ATOM 1675 N NH1 . ARG A 1 219 ? -16.403 -11.019 -26.319 1.00 26.10 ? 219 ARG A NH1 1 ATOM 1676 N NH2 . ARG A 1 219 ? -14.507 -11.176 -25.042 1.00 25.99 ? 219 ARG A NH2 1 ATOM 1677 N N . ALA A 1 220 ? -13.726 -18.418 -25.079 1.00 21.12 ? 220 ALA A N 1 ATOM 1678 C CA . ALA A 1 220 ? -13.899 -19.854 -24.955 1.00 18.86 ? 220 ALA A CA 1 ATOM 1679 C C . ALA A 1 220 ? -14.727 -20.236 -23.722 1.00 18.34 ? 220 ALA A C 1 ATOM 1680 O O . ALA A 1 220 ? -14.586 -19.625 -22.621 1.00 17.76 ? 220 ALA A O 1 ATOM 1681 C CB . ALA A 1 220 ? -12.529 -20.542 -24.940 1.00 18.43 ? 220 ALA A CB 1 ATOM 1682 N N . ILE A 1 221 ? -15.589 -21.235 -23.916 1.00 17.23 ? 221 ILE A N 1 ATOM 1683 C CA . ILE A 1 221 ? -16.433 -21.877 -22.836 1.00 16.66 ? 221 ILE A CA 1 ATOM 1684 C C . ILE A 1 221 ? -16.092 -23.356 -22.729 1.00 18.20 ? 221 ILE A C 1 ATOM 1685 O O . ILE A 1 221 ? -16.196 -24.114 -23.745 1.00 19.00 ? 221 ILE A O 1 ATOM 1686 C CB . ILE A 1 221 ? -17.973 -21.716 -23.157 1.00 15.52 ? 221 ILE A CB 1 ATOM 1687 C CG1 . ILE A 1 221 ? -18.303 -20.231 -23.436 1.00 14.99 ? 221 ILE A CG1 1 ATOM 1688 C CG2 . ILE A 1 221 ? -18.908 -22.347 -22.063 1.00 13.34 ? 221 ILE A CG2 1 ATOM 1689 C CD1 . ILE A 1 221 ? -19.810 -19.953 -23.428 1.00 18.06 ? 221 ILE A CD1 1 ATOM 1690 N N . LEU A 1 222 ? -15.679 -23.806 -21.542 1.00 17.68 ? 222 LEU A N 1 ATOM 1691 C CA . LEU A 1 222 ? -15.386 -25.207 -21.351 1.00 18.72 ? 222 LEU A CA 1 ATOM 1692 C C . LEU A 1 222 ? -16.299 -25.911 -20.350 1.00 19.38 ? 222 LEU A C 1 ATOM 1693 O O . LEU A 1 222 ? -16.122 -25.768 -19.133 1.00 17.81 ? 222 LEU A O 1 ATOM 1694 C CB . LEU A 1 222 ? -13.932 -25.403 -20.909 1.00 19.78 ? 222 LEU A CB 1 ATOM 1695 C CG . LEU A 1 222 ? -12.736 -24.990 -21.783 1.00 22.45 ? 222 LEU A CG 1 ATOM 1696 C CD1 . LEU A 1 222 ? -12.707 -23.499 -21.987 1.00 24.02 ? 222 LEU A CD1 1 ATOM 1697 C CD2 . LEU A 1 222 ? -11.423 -25.415 -21.089 1.00 23.15 ? 222 LEU A CD2 1 ATOM 1698 N N . GLN A 1 223 ? -17.252 -26.704 -20.868 1.00 19.19 ? 223 GLN A N 1 ATOM 1699 C CA . GLN A 1 223 ? -18.164 -27.492 -20.026 1.00 18.09 ? 223 GLN A CA 1 ATOM 1700 C C . GLN A 1 223 ? -17.668 -28.917 -19.793 1.00 19.50 ? 223 GLN A C 1 ATOM 1701 O O . GLN A 1 223 ? -17.573 -29.750 -20.735 1.00 17.83 ? 223 GLN A O 1 ATOM 1702 C CB . GLN A 1 223 ? -19.555 -27.546 -20.669 1.00 18.73 ? 223 GLN A CB 1 ATOM 1703 C CG . GLN A 1 223 ? -20.036 -26.124 -21.025 1.00 18.64 ? 223 GLN A CG 1 ATOM 1704 C CD . GLN A 1 223 ? -21.314 -26.046 -21.856 1.00 23.09 ? 223 GLN A CD 1 ATOM 1705 O OE1 . GLN A 1 223 ? -21.587 -24.981 -22.451 1.00 22.77 ? 223 GLN A OE1 1 ATOM 1706 N NE2 . GLN A 1 223 ? -22.120 -27.144 -21.896 1.00 20.54 ? 223 GLN A NE2 1 ATOM 1707 N N . SER A 1 224 ? -17.396 -29.229 -18.525 1.00 18.78 ? 224 SER A N 1 ATOM 1708 C CA . SER A 1 224 ? -16.924 -30.571 -18.168 1.00 20.18 ? 224 SER A CA 1 ATOM 1709 C C . SER A 1 224 ? -15.758 -31.092 -19.015 1.00 20.91 ? 224 SER A C 1 ATOM 1710 O O . SER A 1 224 ? -15.844 -32.211 -19.543 1.00 20.89 ? 224 SER A O 1 ATOM 1711 C CB . SER A 1 224 ? -18.054 -31.588 -18.227 1.00 18.21 ? 224 SER A CB 1 ATOM 1712 O OG . SER A 1 224 ? -19.175 -31.261 -17.383 1.00 19.79 ? 224 SER A OG 1 ATOM 1713 N N . GLY A 1 225 ? -14.672 -30.328 -19.127 1.00 21.16 ? 225 GLY A N 1 ATOM 1714 C CA . GLY A 1 225 ? -13.500 -30.875 -19.810 1.00 20.54 ? 225 GLY A CA 1 ATOM 1715 C C . GLY A 1 225 ? -12.399 -29.871 -20.027 1.00 20.49 ? 225 GLY A C 1 ATOM 1716 O O . GLY A 1 225 ? -12.680 -28.694 -20.179 1.00 20.48 ? 225 GLY A O 1 ATOM 1717 N N . SER A 1 226 ? -11.150 -30.334 -20.099 1.00 20.00 ? 226 SER A N 1 ATOM 1718 C CA . SER A 1 226 ? -10.032 -29.436 -20.422 1.00 20.36 ? 226 SER A CA 1 ATOM 1719 C C . SER A 1 226 ? -8.922 -30.378 -20.798 1.00 20.66 ? 226 SER A C 1 ATOM 1720 O O . SER A 1 226 ? -8.918 -31.512 -20.308 1.00 19.87 ? 226 SER A O 1 ATOM 1721 C CB . SER A 1 226 ? -9.681 -28.616 -19.140 1.00 18.70 ? 226 SER A CB 1 ATOM 1722 O OG . SER A 1 226 ? -9.477 -29.557 -18.076 1.00 20.74 ? 226 SER A OG 1 ATOM 1723 N N . PHE A 1 227 ? -7.991 -29.953 -21.664 1.00 21.09 ? 227 PHE A N 1 ATOM 1724 C CA . PHE A 1 227 ? -6.962 -30.861 -22.147 1.00 21.93 ? 227 PHE A CA 1 ATOM 1725 C C . PHE A 1 227 ? -6.121 -31.567 -21.059 1.00 23.20 ? 227 PHE A C 1 ATOM 1726 O O . PHE A 1 227 ? -5.472 -32.570 -21.352 1.00 24.20 ? 227 PHE A O 1 ATOM 1727 C CB . PHE A 1 227 ? -5.985 -30.141 -23.131 1.00 22.28 ? 227 PHE A CB 1 ATOM 1728 C CG . PHE A 1 227 ? -4.932 -29.336 -22.409 1.00 24.38 ? 227 PHE A CG 1 ATOM 1729 C CD1 . PHE A 1 227 ? -5.045 -27.963 -22.301 1.00 26.12 ? 227 PHE A CD1 1 ATOM 1730 C CD2 . PHE A 1 227 ? -3.912 -29.993 -21.719 1.00 29.98 ? 227 PHE A CD2 1 ATOM 1731 C CE1 . PHE A 1 227 ? -4.147 -27.252 -21.524 1.00 28.45 ? 227 PHE A CE1 1 ATOM 1732 C CE2 . PHE A 1 227 ? -2.993 -29.282 -20.961 1.00 30.03 ? 227 PHE A CE2 1 ATOM 1733 C CZ . PHE A 1 227 ? -3.131 -27.912 -20.878 1.00 28.62 ? 227 PHE A CZ 1 ATOM 1734 N N . ASN A 1 228 ? -6.039 -31.025 -19.849 1.00 22.03 ? 228 ASN A N 1 ATOM 1735 C CA . ASN A 1 228 ? -5.195 -31.615 -18.806 1.00 21.83 ? 228 ASN A CA 1 ATOM 1736 C C . ASN A 1 228 ? -5.931 -32.736 -18.112 1.00 22.14 ? 228 ASN A C 1 ATOM 1737 O O . ASN A 1 228 ? -5.454 -33.282 -17.092 1.00 22.51 ? 228 ASN A O 1 ATOM 1738 C CB . ASN A 1 228 ? -4.732 -30.547 -17.768 1.00 19.67 ? 228 ASN A CB 1 ATOM 1739 C CG . ASN A 1 228 ? -5.897 -29.783 -17.166 1.00 23.46 ? 228 ASN A CG 1 ATOM 1740 O OD1 . ASN A 1 228 ? -6.840 -29.432 -17.880 1.00 24.27 ? 228 ASN A OD1 1 ATOM 1741 N ND2 . ASN A 1 228 ? -5.856 -29.525 -15.847 1.00 20.19 ? 228 ASN A ND2 1 ATOM 1742 N N . ALA A 1 229 ? -7.123 -33.084 -18.593 1.00 21.80 ? 229 ALA A N 1 ATOM 1743 C CA . ALA A 1 229 ? -7.818 -34.200 -17.944 1.00 21.31 ? 229 ALA A CA 1 ATOM 1744 C C . ALA A 1 229 ? -7.053 -35.475 -18.305 1.00 20.94 ? 229 ALA A C 1 ATOM 1745 O O . ALA A 1 229 ? -6.412 -35.536 -19.333 1.00 19.43 ? 229 ALA A O 1 ATOM 1746 C CB . ALA A 1 229 ? -9.261 -34.266 -18.380 1.00 21.03 ? 229 ALA A CB 1 ATOM 1747 N N . PRO A 1 230 ? -7.090 -36.503 -17.451 1.00 21.20 ? 230 PRO A N 1 ATOM 1748 C CA . PRO A 1 230 ? -6.174 -37.606 -17.745 1.00 22.06 ? 230 PRO A CA 1 ATOM 1749 C C . PRO A 1 230 ? -6.522 -38.397 -19.018 1.00 22.61 ? 230 PRO A C 1 ATOM 1750 O O . PRO A 1 230 ? -5.646 -39.085 -19.562 1.00 23.61 ? 230 PRO A O 1 ATOM 1751 C CB . PRO A 1 230 ? -6.307 -38.525 -16.551 1.00 21.16 ? 230 PRO A CB 1 ATOM 1752 C CG . PRO A 1 230 ? -7.582 -38.159 -15.865 1.00 20.93 ? 230 PRO A CG 1 ATOM 1753 C CD . PRO A 1 230 ? -7.885 -36.722 -16.242 1.00 22.63 ? 230 PRO A CD 1 ATOM 1754 N N . TRP A 1 231 ? -7.756 -38.302 -19.499 1.00 22.73 ? 231 TRP A N 1 ATOM 1755 C CA . TRP A 1 231 ? -8.147 -39.001 -20.753 1.00 22.50 ? 231 TRP A CA 1 ATOM 1756 C C . TRP A 1 231 ? -7.918 -38.188 -22.040 1.00 23.38 ? 231 TRP A C 1 ATOM 1757 O O . TRP A 1 231 ? -8.266 -38.654 -23.147 1.00 24.43 ? 231 TRP A O 1 ATOM 1758 C CB . TRP A 1 231 ? -9.652 -39.294 -20.691 1.00 21.95 ? 231 TRP A CB 1 ATOM 1759 C CG . TRP A 1 231 ? -10.498 -38.105 -20.183 1.00 20.87 ? 231 TRP A CG 1 ATOM 1760 C CD1 . TRP A 1 231 ? -10.924 -37.890 -18.896 1.00 23.70 ? 231 TRP A CD1 1 ATOM 1761 C CD2 . TRP A 1 231 ? -10.993 -36.985 -20.949 1.00 22.81 ? 231 TRP A CD2 1 ATOM 1762 N NE1 . TRP A 1 231 ? -11.645 -36.709 -18.813 1.00 23.08 ? 231 TRP A NE1 1 ATOM 1763 C CE2 . TRP A 1 231 ? -11.717 -36.148 -20.061 1.00 23.28 ? 231 TRP A CE2 1 ATOM 1764 C CE3 . TRP A 1 231 ? -10.936 -36.633 -22.299 1.00 23.38 ? 231 TRP A CE3 1 ATOM 1765 C CZ2 . TRP A 1 231 ? -12.360 -34.971 -20.484 1.00 22.37 ? 231 TRP A CZ2 1 ATOM 1766 C CZ3 . TRP A 1 231 ? -11.566 -35.434 -22.720 1.00 21.61 ? 231 TRP A CZ3 1 ATOM 1767 C CH2 . TRP A 1 231 ? -12.258 -34.631 -21.819 1.00 19.07 ? 231 TRP A CH2 1 ATOM 1768 N N . ALA A 1 232 ? -7.426 -36.957 -21.958 1.00 23.15 ? 232 ALA A N 1 ATOM 1769 C CA . ALA A 1 232 ? -7.602 -36.056 -23.149 1.00 22.02 ? 232 ALA A CA 1 ATOM 1770 C C . ALA A 1 232 ? -6.415 -35.933 -24.090 1.00 23.71 ? 232 ALA A C 1 ATOM 1771 O O . ALA A 1 232 ? -6.551 -35.422 -25.224 1.00 22.13 ? 232 ALA A O 1 ATOM 1772 C CB . ALA A 1 232 ? -8.058 -34.713 -22.745 1.00 21.06 ? 232 ALA A CB 1 ATOM 1773 N N . VAL A 1 233 ? -5.235 -36.375 -23.671 1.00 25.45 ? 233 VAL A N 1 ATOM 1774 C CA . VAL A 1 233 ? -4.100 -36.322 -24.609 1.00 27.55 ? 233 VAL A CA 1 ATOM 1775 C C . VAL A 1 233 ? -3.359 -37.661 -24.618 1.00 30.61 ? 233 VAL A C 1 ATOM 1776 O O . VAL A 1 233 ? -3.024 -38.196 -23.578 1.00 31.09 ? 233 VAL A O 1 ATOM 1777 C CB . VAL A 1 233 ? -3.118 -35.160 -24.256 1.00 27.93 ? 233 VAL A CB 1 ATOM 1778 C CG1 . VAL A 1 233 ? -1.904 -35.122 -25.219 1.00 21.07 ? 233 VAL A CG1 1 ATOM 1779 C CG2 . VAL A 1 233 ? -3.887 -33.790 -24.227 1.00 23.99 ? 233 VAL A CG2 1 ATOM 1780 N N . THR A 1 234 ? -3.136 -38.213 -25.794 1.00 33.20 ? 234 THR A N 1 ATOM 1781 C CA . THR A 1 234 ? -2.370 -39.471 -25.930 1.00 36.17 ? 234 THR A CA 1 ATOM 1782 C C . THR A 1 234 ? -0.868 -39.161 -26.037 1.00 36.94 ? 234 THR A C 1 ATOM 1783 O O . THR A 1 234 ? -0.469 -38.286 -26.808 1.00 37.28 ? 234 THR A O 1 ATOM 1784 C CB . THR A 1 234 ? -2.818 -40.243 -27.215 1.00 36.92 ? 234 THR A CB 1 ATOM 1785 O OG1 . THR A 1 234 ? -4.269 -40.325 -27.287 1.00 37.64 ? 234 THR A OG1 1 ATOM 1786 C CG2 . THR A 1 234 ? -2.192 -41.670 -27.257 1.00 38.50 ? 234 THR A CG2 1 ATOM 1787 N N . SER A 1 235 ? -0.019 -39.839 -25.266 1.00 38.39 ? 235 SER A N 1 ATOM 1788 C CA . SER A 1 235 ? 1.444 -39.651 -25.448 1.00 39.77 ? 235 SER A CA 1 ATOM 1789 C C . SER A 1 235 ? 1.896 -40.200 -26.793 1.00 40.24 ? 235 SER A C 1 ATOM 1790 O O . SER A 1 235 ? 1.204 -41.027 -27.381 1.00 40.87 ? 235 SER A O 1 ATOM 1791 C CB . SER A 1 235 ? 2.202 -40.397 -24.384 1.00 39.64 ? 235 SER A CB 1 ATOM 1792 O OG . SER A 1 235 ? 2.107 -41.776 -24.640 1.00 41.79 ? 235 SER A OG 1 ATOM 1793 N N . LEU A 1 236 ? 3.042 -39.746 -27.285 1.00 41.65 ? 236 LEU A N 1 ATOM 1794 C CA . LEU A 1 236 ? 3.641 -40.310 -28.501 1.00 42.43 ? 236 LEU A CA 1 ATOM 1795 C C . LEU A 1 236 ? 3.932 -41.810 -28.374 1.00 43.45 ? 236 LEU A C 1 ATOM 1796 O O . LEU A 1 236 ? 3.722 -42.582 -29.302 1.00 42.78 ? 236 LEU A O 1 ATOM 1797 C CB . LEU A 1 236 ? 4.924 -39.585 -28.832 1.00 42.90 ? 236 LEU A CB 1 ATOM 1798 C CG . LEU A 1 236 ? 4.706 -38.614 -29.984 1.00 44.75 ? 236 LEU A CG 1 ATOM 1799 C CD1 . LEU A 1 236 ? 3.278 -38.126 -29.946 1.00 43.51 ? 236 LEU A CD1 1 ATOM 1800 C CD2 . LEU A 1 236 ? 5.710 -37.459 -29.931 1.00 45.89 ? 236 LEU A CD2 1 ATOM 1801 N N . TYR A 1 237 ? 4.416 -42.221 -27.211 1.00 44.27 ? 237 TYR A N 1 ATOM 1802 C CA . TYR A 1 237 ? 4.593 -43.629 -26.948 1.00 45.16 ? 237 TYR A CA 1 ATOM 1803 C C . TYR A 1 237 ? 3.286 -44.360 -27.225 1.00 44.94 ? 237 TYR A C 1 ATOM 1804 O O . TYR A 1 237 ? 3.223 -45.155 -28.155 1.00 45.15 ? 237 TYR A O 1 ATOM 1805 C CB . TYR A 1 237 ? 5.089 -43.901 -25.508 1.00 45.61 ? 237 TYR A CB 1 ATOM 1806 C CG . TYR A 1 237 ? 5.058 -45.372 -25.170 0.50 47.07 ? 237 TYR A CG 1 ATOM 1807 C CD1 . TYR A 1 237 ? 5.553 -46.318 -26.073 0.50 48.68 ? 237 TYR A CD1 1 ATOM 1808 C CD2 . TYR A 1 237 ? 4.519 -45.826 -23.968 0.50 47.51 ? 237 TYR A CD2 1 ATOM 1809 C CE1 . TYR A 1 237 ? 5.512 -47.666 -25.793 0.50 48.52 ? 237 TYR A CE1 1 ATOM 1810 C CE2 . TYR A 1 237 ? 4.479 -47.180 -23.678 0.50 48.48 ? 237 TYR A CE2 1 ATOM 1811 C CZ . TYR A 1 237 ? 4.976 -48.096 -24.598 0.50 48.91 ? 237 TYR A CZ 1 ATOM 1812 O OH . TYR A 1 237 ? 4.946 -49.448 -24.326 0.50 49.69 ? 237 TYR A OH 1 ATOM 1813 N N . GLU A 1 238 ? 2.261 -44.110 -26.415 1.00 43.96 ? 238 GLU A N 1 ATOM 1814 C CA . GLU A 1 238 ? 0.975 -44.776 -26.588 1.00 43.66 ? 238 GLU A CA 1 ATOM 1815 C C . GLU A 1 238 ? 0.440 -44.730 -28.017 1.00 43.48 ? 238 GLU A C 1 ATOM 1816 O O . GLU A 1 238 ? -0.091 -45.708 -28.501 1.00 43.42 ? 238 GLU A O 1 ATOM 1817 C CB . GLU A 1 238 ? -0.084 -44.103 -25.724 1.00 43.82 ? 238 GLU A CB 1 ATOM 1818 C CG . GLU A 1 238 ? -0.039 -44.402 -24.256 1.00 45.16 ? 238 GLU A CG 1 ATOM 1819 C CD . GLU A 1 238 ? -0.828 -43.343 -23.458 1.00 47.30 ? 238 GLU A CD 1 ATOM 1820 O OE1 . GLU A 1 238 ? -0.967 -42.198 -23.963 1.00 45.65 ? 238 GLU A OE1 1 ATOM 1821 O OE2 . GLU A 1 238 ? -1.305 -43.659 -22.342 1.00 44.98 ? 238 GLU A OE2 1 ATOM 1822 N N . ALA A 1 239 ? 0.498 -43.576 -28.665 1.00 43.39 ? 239 ALA A N 1 ATOM 1823 C CA . ALA A 1 239 ? -0.042 -43.459 -30.007 1.00 44.53 ? 239 ALA A CA 1 ATOM 1824 C C . ALA A 1 239 ? 0.641 -44.429 -30.973 1.00 45.37 ? 239 ALA A C 1 ATOM 1825 O O . ALA A 1 239 ? -0.031 -45.152 -31.701 1.00 44.98 ? 239 ALA A O 1 ATOM 1826 C CB . ALA A 1 239 ? 0.067 -42.010 -30.540 1.00 44.30 ? 239 ALA A CB 1 ATOM 1827 N N . ARG A 1 240 ? 1.976 -44.414 -30.999 1.00 46.65 ? 240 ARG A N 1 ATOM 1828 C CA . ARG A 1 240 ? 2.771 -45.382 -31.780 1.00 47.48 ? 240 ARG A CA 1 ATOM 1829 C C . ARG A 1 240 ? 2.336 -46.812 -31.500 1.00 46.63 ? 240 ARG A C 1 ATOM 1830 O O . ARG A 1 240 ? 2.021 -47.548 -32.421 1.00 46.01 ? 240 ARG A O 1 ATOM 1831 C CB . ARG A 1 240 ? 4.238 -45.258 -31.398 1.00 48.63 ? 240 ARG A CB 1 ATOM 1832 C CG . ARG A 1 240 ? 4.847 -43.907 -31.763 1.00 54.30 ? 240 ARG A CG 1 ATOM 1833 C CD . ARG A 1 240 ? 5.380 -43.948 -33.201 1.00 60.88 ? 240 ARG A CD 1 ATOM 1834 N NE . ARG A 1 240 ? 5.932 -45.277 -33.460 1.00 64.85 ? 240 ARG A NE 1 ATOM 1835 C CZ . ARG A 1 240 ? 6.693 -45.580 -34.501 1.00 64.96 ? 240 ARG A CZ 1 ATOM 1836 N NH1 . ARG A 1 240 ? 7.005 -44.637 -35.381 1.00 65.06 ? 240 ARG A NH1 1 ATOM 1837 N NH2 . ARG A 1 240 ? 7.135 -46.822 -34.647 1.00 63.95 ? 240 ARG A NH2 1 ATOM 1838 N N . ASN A 1 241 ? 2.304 -47.195 -30.224 1.00 46.35 ? 241 ASN A N 1 ATOM 1839 C CA . ASN A 1 241 ? 1.930 -48.552 -29.865 1.00 46.68 ? 241 ASN A CA 1 ATOM 1840 C C . ASN A 1 241 ? 0.560 -48.875 -30.427 1.00 45.88 ? 241 ASN A C 1 ATOM 1841 O O . ASN A 1 241 ? 0.266 -50.026 -30.814 1.00 46.05 ? 241 ASN A O 1 ATOM 1842 C CB . ASN A 1 241 ? 1.912 -48.763 -28.341 1.00 47.99 ? 241 ASN A CB 1 ATOM 1843 C CG . ASN A 1 241 ? 2.187 -50.234 -27.932 1.00 51.68 ? 241 ASN A CG 1 ATOM 1844 O OD1 . ASN A 1 241 ? 3.252 -50.775 -28.240 1.00 52.76 ? 241 ASN A OD1 1 ATOM 1845 N ND2 . ASN A 1 241 ? 1.230 -50.869 -27.241 1.00 57.15 ? 241 ASN A ND2 1 ATOM 1846 N N . ARG A 1 242 ? -0.299 -47.864 -30.464 1.00 44.36 ? 242 ARG A N 1 ATOM 1847 C CA . ARG A 1 242 ? -1.692 -48.106 -30.808 1.00 42.89 ? 242 ARG A CA 1 ATOM 1848 C C . ARG A 1 242 ? -1.887 -48.184 -32.306 1.00 42.22 ? 242 ARG A C 1 ATOM 1849 O O . ARG A 1 242 ? -2.596 -49.039 -32.797 1.00 41.21 ? 242 ARG A O 1 ATOM 1850 C CB . ARG A 1 242 ? -2.601 -47.065 -30.164 1.00 42.47 ? 242 ARG A CB 1 ATOM 1851 C CG . ARG A 1 242 ? -2.755 -47.296 -28.691 1.00 40.19 ? 242 ARG A CG 1 ATOM 1852 C CD . ARG A 1 242 ? -3.233 -46.022 -28.034 1.00 40.15 ? 242 ARG A CD 1 ATOM 1853 N NE . ARG A 1 242 ? -3.213 -46.077 -26.566 1.00 36.23 ? 242 ARG A NE 1 ATOM 1854 C CZ . ARG A 1 242 ? -3.832 -45.182 -25.802 1.00 36.82 ? 242 ARG A CZ 1 ATOM 1855 N NH1 . ARG A 1 242 ? -4.500 -44.157 -26.354 1.00 34.07 ? 242 ARG A NH1 1 ATOM 1856 N NH2 . ARG A 1 242 ? -3.780 -45.298 -24.492 1.00 33.90 ? 242 ARG A NH2 1 ATOM 1857 N N . THR A 1 243 ? -1.228 -47.297 -33.027 1.00 42.75 ? 243 THR A N 1 ATOM 1858 C CA . THR A 1 243 ? -1.231 -47.361 -34.479 1.00 44.05 ? 243 THR A CA 1 ATOM 1859 C C . THR A 1 243 ? -0.741 -48.734 -34.967 1.00 44.75 ? 243 THR A C 1 ATOM 1860 O O . THR A 1 243 ? -1.358 -49.335 -35.847 1.00 45.12 ? 243 THR A O 1 ATOM 1861 C CB . THR A 1 243 ? -0.334 -46.286 -35.061 1.00 44.03 ? 243 THR A CB 1 ATOM 1862 O OG1 . THR A 1 243 ? -0.860 -45.000 -34.718 1.00 43.70 ? 243 THR A OG1 1 ATOM 1863 C CG2 . THR A 1 243 ? -0.257 -46.409 -36.581 1.00 45.06 ? 243 THR A CG2 1 ATOM 1864 N N . LEU A 1 244 ? 0.356 -49.222 -34.386 1.00 45.35 ? 244 LEU A N 1 ATOM 1865 C CA . LEU A 1 244 ? 0.939 -50.537 -34.728 1.00 45.39 ? 244 LEU A CA 1 ATOM 1866 C C . LEU A 1 244 ? 0.059 -51.685 -34.313 1.00 45.90 ? 244 LEU A C 1 ATOM 1867 O O . LEU A 1 244 ? -0.108 -52.650 -35.077 1.00 46.44 ? 244 LEU A O 1 ATOM 1868 C CB . LEU A 1 244 ? 2.279 -50.751 -34.053 1.00 45.28 ? 244 LEU A CB 1 ATOM 1869 C CG . LEU A 1 244 ? 3.366 -49.778 -34.469 1.00 45.24 ? 244 LEU A CG 1 ATOM 1870 C CD1 . LEU A 1 244 ? 4.693 -50.186 -33.813 1.00 44.75 ? 244 LEU A CD1 1 ATOM 1871 C CD2 . LEU A 1 244 ? 3.435 -49.677 -35.983 1.00 43.77 ? 244 LEU A CD2 1 ATOM 1872 N N . ASN A 1 245 ? -0.483 -51.621 -33.099 1.00 45.92 ? 245 ASN A N 1 ATOM 1873 C CA . ASN A 1 245 ? -1.504 -52.594 -32.703 1.00 45.71 ? 245 ASN A CA 1 ATOM 1874 C C . ASN A 1 245 ? -2.703 -52.644 -33.658 1.00 45.72 ? 245 ASN A C 1 ATOM 1875 O O . ASN A 1 245 ? -3.175 -53.724 -34.003 1.00 46.38 ? 245 ASN A O 1 ATOM 1876 C CB . ASN A 1 245 ? -1.974 -52.349 -31.284 1.00 46.10 ? 245 ASN A CB 1 ATOM 1877 C CG . ASN A 1 245 ? -0.916 -52.696 -30.269 1.00 47.67 ? 245 ASN A CG 1 ATOM 1878 O OD1 . ASN A 1 245 ? 0.124 -53.253 -30.630 1.00 50.01 ? 245 ASN A OD1 1 ATOM 1879 N ND2 . ASN A 1 245 ? -1.164 -52.381 -28.996 1.00 42.12 ? 245 ASN A ND2 1 ATOM 1880 N N . LEU A 1 246 ? -3.229 -51.492 -34.054 1.00 44.90 ? 246 LEU A N 1 ATOM 1881 C CA . LEU A 1 246 ? -4.286 -51.485 -35.044 1.00 44.50 ? 246 LEU A CA 1 ATOM 1882 C C . LEU A 1 246 ? -3.811 -52.183 -36.329 1.00 45.18 ? 246 LEU A C 1 ATOM 1883 O O . LEU A 1 246 ? -4.557 -52.960 -36.927 1.00 44.26 ? 246 LEU A O 1 ATOM 1884 C CB . LEU A 1 246 ? -4.733 -50.058 -35.376 1.00 43.84 ? 246 LEU A CB 1 ATOM 1885 C CG . LEU A 1 246 ? -6.007 -49.959 -36.219 1.00 42.53 ? 246 LEU A CG 1 ATOM 1886 C CD1 . LEU A 1 246 ? -7.188 -50.560 -35.488 1.00 36.01 ? 246 LEU A CD1 1 ATOM 1887 C CD2 . LEU A 1 246 ? -6.285 -48.523 -36.634 1.00 40.07 ? 246 LEU A CD2 1 ATOM 1888 N N . ALA A 1 247 ? -2.575 -51.896 -36.746 1.00 45.92 ? 247 ALA A N 1 ATOM 1889 C CA . ALA A 1 247 ? -2.038 -52.408 -37.996 1.00 47.10 ? 247 ALA A CA 1 ATOM 1890 C C . ALA A 1 247 ? -2.008 -53.915 -37.881 1.00 48.26 ? 247 ALA A C 1 ATOM 1891 O O . ALA A 1 247 ? -2.648 -54.657 -38.652 1.00 49.13 ? 247 ALA A O 1 ATOM 1892 C CB . ALA A 1 247 ? -0.630 -51.877 -38.224 1.00 46.50 ? 247 ALA A CB 1 ATOM 1893 N N . LYS A 1 248 ? -1.288 -54.371 -36.878 1.00 48.71 ? 248 LYS A N 1 ATOM 1894 C CA . LYS A 1 248 ? -1.269 -55.780 -36.576 1.00 49.63 ? 248 LYS A CA 1 ATOM 1895 C C . LYS A 1 248 ? -2.658 -56.418 -36.649 1.00 49.41 ? 248 LYS A C 1 ATOM 1896 O O . LYS A 1 248 ? -2.831 -57.455 -37.307 1.00 50.04 ? 248 LYS A O 1 ATOM 1897 C CB . LYS A 1 248 ? -0.601 -56.018 -35.236 1.00 49.97 ? 248 LYS A CB 1 ATOM 1898 C CG . LYS A 1 248 ? -0.449 -57.464 -34.868 1.00 53.31 ? 248 LYS A CG 1 ATOM 1899 C CD . LYS A 1 248 ? 0.393 -57.577 -33.592 1.00 57.88 ? 248 LYS A CD 1 ATOM 1900 C CE . LYS A 1 248 ? 0.002 -58.819 -32.767 1.00 62.47 ? 248 LYS A CE 1 ATOM 1901 N NZ . LYS A 1 248 ? 0.041 -60.087 -33.589 1.00 62.71 ? 248 LYS A NZ 1 ATOM 1902 N N . LEU A 1 249 ? -3.654 -55.810 -36.011 1.00 48.98 ? 249 LEU A N 1 ATOM 1903 C CA . LEU A 1 249 ? -4.985 -56.427 -35.912 1.00 47.83 ? 249 LEU A CA 1 ATOM 1904 C C . LEU A 1 249 ? -5.732 -56.447 -37.228 1.00 47.58 ? 249 LEU A C 1 ATOM 1905 O O . LEU A 1 249 ? -6.743 -57.139 -37.370 1.00 47.14 ? 249 LEU A O 1 ATOM 1906 C CB . LEU A 1 249 ? -5.846 -55.705 -34.884 1.00 48.35 ? 249 LEU A CB 1 ATOM 1907 C CG . LEU A 1 249 ? -5.533 -55.920 -33.403 1.00 49.44 ? 249 LEU A CG 1 ATOM 1908 C CD1 . LEU A 1 249 ? -5.896 -54.679 -32.591 1.00 51.02 ? 249 LEU A CD1 1 ATOM 1909 C CD2 . LEU A 1 249 ? -6.276 -57.111 -32.883 1.00 49.54 ? 249 LEU A CD2 1 ATOM 1910 N N . THR A 1 250 ? -5.267 -55.668 -38.190 1.00 46.71 ? 250 THR A N 1 ATOM 1911 C CA . THR A 1 250 ? -5.968 -55.611 -39.450 1.00 47.23 ? 250 THR A CA 1 ATOM 1912 C C . THR A 1 250 ? -5.061 -56.226 -40.512 1.00 48.66 ? 250 THR A C 1 ATOM 1913 O O . THR A 1 250 ? -5.178 -55.941 -41.714 1.00 48.65 ? 250 THR A O 1 ATOM 1914 C CB . THR A 1 250 ? -6.334 -54.149 -39.868 1.00 46.67 ? 250 THR A CB 1 ATOM 1915 O OG1 . THR A 1 250 ? -5.157 -53.326 -39.887 1.00 42.85 ? 250 THR A OG1 1 ATOM 1916 C CG2 . THR A 1 250 ? -7.375 -53.564 -38.965 1.00 45.56 ? 250 THR A CG2 1 ATOM 1917 N N . GLY A 1 251 ? -4.145 -57.066 -40.053 1.00 49.58 ? 251 GLY A N 1 ATOM 1918 C CA . GLY A 1 251 ? -3.136 -57.593 -40.950 1.00 50.94 ? 251 GLY A CA 1 ATOM 1919 C C . GLY A 1 251 ? -2.440 -56.524 -41.769 1.00 51.43 ? 251 GLY A C 1 ATOM 1920 O O . GLY A 1 251 ? -2.062 -56.766 -42.913 1.00 51.91 ? 251 GLY A O 1 ATOM 1921 N N . CYS A 1 252 ? -2.229 -55.350 -41.198 1.00 51.61 ? 252 CYS A N 1 ATOM 1922 C CA . CYS A 1 252 ? -1.578 -54.296 -41.966 1.00 52.28 ? 252 CYS A CA 1 ATOM 1923 C C . CYS A 1 252 ? -0.166 -54.038 -41.524 1.00 53.42 ? 252 CYS A C 1 ATOM 1924 O O . CYS A 1 252 ? 0.469 -53.085 -42.005 1.00 53.11 ? 252 CYS A O 1 ATOM 1925 C CB . CYS A 1 252 ? -2.359 -52.994 -41.904 1.00 51.91 ? 252 CYS A CB 1 ATOM 1926 S SG . CYS A 1 252 ? -3.722 -52.881 -43.072 1.00 51.73 ? 252 CYS A SG 1 ATOM 1927 N N . SER A 1 253 ? 0.336 -54.853 -40.604 1.00 54.77 ? 253 SER A N 1 ATOM 1928 C CA . SER A 1 253 ? 1.726 -54.683 -40.201 1.00 56.66 ? 253 SER A CA 1 ATOM 1929 C C . SER A 1 253 ? 2.629 -54.696 -41.444 1.00 58.28 ? 253 SER A C 1 ATOM 1930 O O . SER A 1 253 ? 2.403 -55.465 -42.383 1.00 58.68 ? 253 SER A O 1 ATOM 1931 C CB . SER A 1 253 ? 2.157 -55.757 -39.207 1.00 56.84 ? 253 SER A CB 1 ATOM 1932 O OG . SER A 1 253 ? 1.385 -55.692 -38.021 1.00 56.88 ? 253 SER A OG 1 ATOM 1933 N N . ARG A 1 254 ? 3.622 -53.807 -41.452 1.00 60.00 ? 254 ARG A N 1 ATOM 1934 C CA . ARG A 1 254 ? 4.600 -53.659 -42.535 1.00 61.09 ? 254 ARG A CA 1 ATOM 1935 C C . ARG A 1 254 ? 5.914 -53.337 -41.848 1.00 62.74 ? 254 ARG A C 1 ATOM 1936 O O . ARG A 1 254 ? 5.980 -53.219 -40.627 1.00 63.19 ? 254 ARG A O 1 ATOM 1937 C CB . ARG A 1 254 ? 4.244 -52.481 -43.454 1.00 60.76 ? 254 ARG A CB 1 ATOM 1938 C CG . ARG A 1 254 ? 3.586 -52.835 -44.783 1.00 58.94 ? 254 ARG A CG 1 ATOM 1939 C CD . ARG A 1 254 ? 2.895 -54.174 -44.706 1.00 54.38 ? 254 ARG A CD 1 ATOM 1940 N NE . ARG A 1 254 ? 1.846 -54.322 -45.708 1.00 49.43 ? 254 ARG A NE 1 ATOM 1941 C CZ . ARG A 1 254 ? 0.871 -55.208 -45.577 1.00 46.85 ? 254 ARG A CZ 1 ATOM 1942 N NH1 . ARG A 1 254 ? -0.092 -55.312 -46.482 1.00 44.72 ? 254 ARG A NH1 1 ATOM 1943 N NH2 . ARG A 1 254 ? 0.862 -55.981 -44.511 1.00 43.45 ? 254 ARG A NH2 1 ATOM 1944 N N . GLU A 1 255 ? 6.966 -53.187 -42.629 1.00 64.28 ? 255 GLU A N 1 ATOM 1945 C CA . GLU A 1 255 ? 8.228 -52.751 -42.088 1.00 65.88 ? 255 GLU A CA 1 ATOM 1946 C C . GLU A 1 255 ? 8.323 -51.265 -42.366 1.00 66.17 ? 255 GLU A C 1 ATOM 1947 O O . GLU A 1 255 ? 8.877 -50.521 -41.571 1.00 66.67 ? 255 GLU A O 1 ATOM 1948 C CB . GLU A 1 255 ? 9.372 -53.517 -42.756 1.00 66.45 ? 255 GLU A CB 1 ATOM 1949 C CG . GLU A 1 255 ? 9.216 -53.651 -44.304 1.00 69.39 ? 255 GLU A CG 1 ATOM 1950 C CD . GLU A 1 255 ? 7.798 -54.097 -44.769 1.00 71.70 ? 255 GLU A CD 1 ATOM 1951 O OE1 . GLU A 1 255 ? 7.113 -53.282 -45.451 1.00 72.18 ? 255 GLU A OE1 1 ATOM 1952 O OE2 . GLU A 1 255 ? 7.381 -55.253 -44.461 1.00 72.10 ? 255 GLU A OE2 1 ATOM 1953 N N . ASN A 1 256 ? 7.769 -50.842 -43.501 1.00 66.41 ? 256 ASN A N 1 ATOM 1954 C CA . ASN A 1 256 ? 7.743 -49.438 -43.896 1.00 66.38 ? 256 ASN A CA 1 ATOM 1955 C C . ASN A 1 256 ? 6.433 -48.823 -43.410 1.00 65.62 ? 256 ASN A C 1 ATOM 1956 O O . ASN A 1 256 ? 5.339 -49.335 -43.726 1.00 65.67 ? 256 ASN A O 1 ATOM 1957 C CB . ASN A 1 256 ? 7.849 -49.321 -45.419 1.00 67.27 ? 256 ASN A CB 1 ATOM 1958 C CG . ASN A 1 256 ? 7.922 -47.872 -45.908 1.00 70.78 ? 256 ASN A CG 1 ATOM 1959 O OD1 . ASN A 1 256 ? 6.972 -47.086 -45.766 1.00 71.08 ? 256 ASN A OD1 1 ATOM 1960 N ND2 . ASN A 1 256 ? 9.063 -47.524 -46.502 1.00 77.26 ? 256 ASN A ND2 1 ATOM 1961 N N . GLU A 1 257 ? 6.547 -47.732 -42.649 1.00 64.11 ? 257 GLU A N 1 ATOM 1962 C CA . GLU A 1 257 ? 5.397 -47.124 -41.982 1.00 62.45 ? 257 GLU A CA 1 ATOM 1963 C C . GLU A 1 257 ? 4.406 -46.528 -42.948 1.00 61.42 ? 257 GLU A C 1 ATOM 1964 O O . GLU A 1 257 ? 3.208 -46.557 -42.692 1.00 61.16 ? 257 GLU A O 1 ATOM 1965 C CB . GLU A 1 257 ? 5.842 -46.060 -40.981 1.00 62.63 ? 257 GLU A CB 1 ATOM 1966 C CG . GLU A 1 257 ? 6.675 -46.636 -39.841 1.00 62.59 ? 257 GLU A CG 1 ATOM 1967 C CD . GLU A 1 257 ? 6.846 -45.655 -38.695 1.00 61.90 ? 257 GLU A CD 1 ATOM 1968 O OE1 . GLU A 1 257 ? 6.709 -44.436 -38.944 1.00 58.57 ? 257 GLU A OE1 1 ATOM 1969 O OE2 . GLU A 1 257 ? 7.113 -46.115 -37.556 1.00 60.72 ? 257 GLU A OE2 1 ATOM 1970 N N . THR A 1 258 ? 4.895 -45.987 -44.057 1.00 60.03 ? 258 THR A N 1 ATOM 1971 C CA . THR A 1 258 ? 3.991 -45.412 -45.039 1.00 58.73 ? 258 THR A CA 1 ATOM 1972 C C . THR A 1 258 ? 3.171 -46.521 -45.669 0.50 57.96 ? 258 THR A C 1 ATOM 1973 O O . THR A 1 258 ? 2.101 -46.280 -46.219 0.50 57.44 ? 258 THR A O 1 ATOM 1974 C CB . THR A 1 258 ? 4.742 -44.594 -46.098 0.50 58.73 ? 258 THR A CB 1 ATOM 1975 O OG1 . THR A 1 258 ? 5.472 -43.554 -45.442 0.50 57.48 ? 258 THR A OG1 1 ATOM 1976 C CG2 . THR A 1 258 ? 3.763 -43.968 -47.087 0.50 58.60 ? 258 THR A CG2 1 ATOM 1977 N N . GLU A 1 259 ? 3.675 -47.744 -45.546 1.00 57.36 ? 259 GLU A N 1 ATOM 1978 C CA . GLU A 1 259 ? 3.007 -48.919 -46.103 1.00 57.12 ? 259 GLU A CA 1 ATOM 1979 C C . GLU A 1 259 ? 1.935 -49.372 -45.136 1.00 55.31 ? 259 GLU A C 1 ATOM 1980 O O . GLU A 1 259 ? 0.890 -49.878 -45.531 1.00 55.33 ? 259 GLU A O 1 ATOM 1981 C CB . GLU A 1 259 ? 3.988 -50.077 -46.328 1.00 57.53 ? 259 GLU A CB 1 ATOM 1982 C CG . GLU A 1 259 ? 5.340 -49.668 -46.899 1.00 62.76 ? 259 GLU A CG 1 ATOM 1983 C CD . GLU A 1 259 ? 5.543 -50.048 -48.377 1.00 68.46 ? 259 GLU A CD 1 ATOM 1984 O OE1 . GLU A 1 259 ? 6.385 -50.952 -48.651 1.00 68.80 ? 259 GLU A OE1 1 ATOM 1985 O OE2 . GLU A 1 259 ? 4.879 -49.427 -49.255 1.00 71.20 ? 259 GLU A OE2 1 ATOM 1986 N N . ILE A 1 260 ? 2.201 -49.209 -43.856 1.00 53.87 ? 260 ILE A N 1 ATOM 1987 C CA . ILE A 1 260 ? 1.157 -49.449 -42.882 1.00 52.82 ? 260 ILE A CA 1 ATOM 1988 C C . ILE A 1 260 ? -0.056 -48.576 -43.214 1.00 51.59 ? 260 ILE A C 1 ATOM 1989 O O . ILE A 1 260 ? -1.169 -49.067 -43.330 1.00 51.90 ? 260 ILE A O 1 ATOM 1990 C CB . ILE A 1 260 ? 1.655 -49.188 -41.463 1.00 52.48 ? 260 ILE A CB 1 ATOM 1991 C CG1 . ILE A 1 260 ? 2.922 -49.977 -41.230 1.00 52.82 ? 260 ILE A CG1 1 ATOM 1992 C CG2 . ILE A 1 260 ? 0.617 -49.616 -40.424 1.00 52.28 ? 260 ILE A CG2 1 ATOM 1993 C CD1 . ILE A 1 260 ? 3.114 -50.319 -39.778 1.00 56.12 ? 260 ILE A CD1 1 ATOM 1994 N N . ILE A 1 261 ? 0.172 -47.286 -43.409 1.00 50.41 ? 261 ILE A N 1 ATOM 1995 C CA . ILE A 1 261 ? -0.927 -46.362 -43.636 1.00 49.61 ? 261 ILE A CA 1 ATOM 1996 C C . ILE A 1 261 ? -1.640 -46.693 -44.936 1.00 49.45 ? 261 ILE A C 1 ATOM 1997 O O . ILE A 1 261 ? -2.868 -46.591 -45.038 1.00 49.36 ? 261 ILE A O 1 ATOM 1998 C CB . ILE A 1 261 ? -0.469 -44.868 -43.687 1.00 49.25 ? 261 ILE A CB 1 ATOM 1999 C CG1 . ILE A 1 261 ? 0.355 -44.500 -42.463 1.00 49.43 ? 261 ILE A CG1 1 ATOM 2000 C CG2 . ILE A 1 261 ? -1.664 -43.952 -43.788 1.00 48.59 ? 261 ILE A CG2 1 ATOM 2001 C CD1 . ILE A 1 261 ? -0.281 -44.939 -41.136 1.00 51.81 ? 261 ILE A CD1 1 ATOM 2002 N N . LYS A 1 262 ? -0.856 -47.033 -45.951 1.00 49.41 ? 262 LYS A N 1 ATOM 2003 C CA . LYS A 1 262 ? -1.411 -47.348 -47.262 1.00 48.70 ? 262 LYS A CA 1 ATOM 2004 C C . LYS A 1 262 ? -2.312 -48.574 -47.109 1.00 47.19 ? 262 LYS A C 1 ATOM 2005 O O . LYS A 1 262 ? -3.453 -48.590 -47.578 1.00 46.76 ? 262 LYS A O 1 ATOM 2006 C CB . LYS A 1 262 ? -0.280 -47.616 -48.231 1.00 49.11 ? 262 LYS A CB 1 ATOM 2007 C CG . LYS A 1 262 ? -0.578 -47.133 -49.628 1.00 52.19 ? 262 LYS A CG 1 ATOM 2008 C CD . LYS A 1 262 ? -1.562 -48.049 -50.356 1.00 57.29 ? 262 LYS A CD 1 ATOM 2009 C CE . LYS A 1 262 ? -0.873 -48.810 -51.516 1.00 60.03 ? 262 LYS A CE 1 ATOM 2010 N NZ . LYS A 1 262 ? -0.117 -47.883 -52.425 1.00 60.48 ? 262 LYS A NZ 1 ATOM 2011 N N . CYS A 1 263 ? -1.815 -49.577 -46.393 1.00 45.91 ? 263 CYS A N 1 ATOM 2012 C CA . CYS A 1 263 ? -2.624 -50.750 -46.110 1.00 45.18 ? 263 CYS A CA 1 ATOM 2013 C C . CYS A 1 263 ? -3.931 -50.387 -45.414 1.00 45.00 ? 263 CYS A C 1 ATOM 2014 O O . CYS A 1 263 ? -5.014 -50.809 -45.846 1.00 44.92 ? 263 CYS A O 1 ATOM 2015 C CB . CYS A 1 263 ? -1.853 -51.723 -45.244 1.00 45.63 ? 263 CYS A CB 1 ATOM 2016 S SG . CYS A 1 263 ? -2.783 -53.215 -44.877 1.00 45.80 ? 263 CYS A SG 1 ATOM 2017 N N . LEU A 1 264 ? -3.833 -49.596 -44.335 1.00 43.75 ? 264 LEU A N 1 ATOM 2018 C CA . LEU A 1 264 ? -5.020 -49.153 -43.574 1.00 41.81 ? 264 LEU A CA 1 ATOM 2019 C C . LEU A 1 264 ? -5.978 -48.324 -44.433 1.00 41.43 ? 264 LEU A C 1 ATOM 2020 O O . LEU A 1 264 ? -7.181 -48.338 -44.245 1.00 39.83 ? 264 LEU A O 1 ATOM 2021 C CB . LEU A 1 264 ? -4.593 -48.392 -42.316 1.00 41.52 ? 264 LEU A CB 1 ATOM 2022 C CG . LEU A 1 264 ? -4.058 -49.262 -41.169 1.00 41.43 ? 264 LEU A CG 1 ATOM 2023 C CD1 . LEU A 1 264 ? -3.297 -48.402 -40.161 1.00 38.65 ? 264 LEU A CD1 1 ATOM 2024 C CD2 . LEU A 1 264 ? -5.201 -50.048 -40.475 1.00 39.37 ? 264 LEU A CD2 1 ATOM 2025 N N . ARG A 1 265 ? -5.452 -47.612 -45.410 1.00 41.94 ? 265 ARG A N 1 ATOM 2026 C CA . ARG A 1 265 ? -6.330 -46.898 -46.286 1.00 42.85 ? 265 ARG A CA 1 ATOM 2027 C C . ARG A 1 265 ? -7.148 -47.818 -47.174 1.00 44.62 ? 265 ARG A C 1 ATOM 2028 O O . ARG A 1 265 ? -8.084 -47.368 -47.832 1.00 45.52 ? 265 ARG A O 1 ATOM 2029 C CB . ARG A 1 265 ? -5.533 -45.933 -47.131 1.00 43.07 ? 265 ARG A CB 1 ATOM 2030 C CG . ARG A 1 265 ? -5.411 -44.555 -46.514 1.00 44.50 ? 265 ARG A CG 1 ATOM 2031 C CD . ARG A 1 265 ? -5.160 -43.509 -47.573 1.00 46.95 ? 265 ARG A CD 1 ATOM 2032 N NE . ARG A 1 265 ? -3.762 -43.193 -47.443 1.00 53.87 ? 265 ARG A NE 1 ATOM 2033 C CZ . ARG A 1 265 ? -2.789 -43.666 -48.218 1.00 56.06 ? 265 ARG A CZ 1 ATOM 2034 N NH1 . ARG A 1 265 ? -1.545 -43.322 -47.935 1.00 54.03 ? 265 ARG A NH1 1 ATOM 2035 N NH2 . ARG A 1 265 ? -3.048 -44.452 -49.272 1.00 56.68 ? 265 ARG A NH2 1 ATOM 2036 N N . ASN A 1 266 ? -6.786 -49.100 -47.225 1.00 46.05 ? 266 ASN A N 1 ATOM 2037 C CA . ASN A 1 266 ? -7.535 -50.062 -48.023 1.00 47.52 ? 266 ASN A CA 1 ATOM 2038 C C . ASN A 1 266 ? -8.565 -50.778 -47.224 1.00 47.41 ? 266 ASN A C 1 ATOM 2039 O O . ASN A 1 266 ? -9.505 -51.305 -47.807 1.00 48.43 ? 266 ASN A O 1 ATOM 2040 C CB . ASN A 1 266 ? -6.619 -51.104 -48.661 1.00 48.44 ? 266 ASN A CB 1 ATOM 2041 C CG . ASN A 1 266 ? -5.825 -50.540 -49.783 1.00 50.90 ? 266 ASN A CG 1 ATOM 2042 O OD1 . ASN A 1 266 ? -6.347 -49.765 -50.597 1.00 54.39 ? 266 ASN A OD1 1 ATOM 2043 N ND2 . ASN A 1 266 ? -4.547 -50.902 -49.846 1.00 53.60 ? 266 ASN A ND2 1 ATOM 2044 N N . LYS A 1 267 ? -8.408 -50.817 -45.901 1.00 47.56 ? 267 LYS A N 1 ATOM 2045 C CA . LYS A 1 267 ? -9.436 -51.423 -45.035 1.00 47.20 ? 267 LYS A CA 1 ATOM 2046 C C . LYS A 1 267 ? -10.761 -50.703 -45.110 1.00 47.40 ? 267 LYS A C 1 ATOM 2047 O O . LYS A 1 267 ? -10.822 -49.540 -45.467 1.00 47.21 ? 267 LYS A O 1 ATOM 2048 C CB . LYS A 1 267 ? -8.981 -51.535 -43.588 1.00 47.00 ? 267 LYS A CB 1 ATOM 2049 C CG . LYS A 1 267 ? -7.633 -52.176 -43.465 1.00 47.94 ? 267 LYS A CG 1 ATOM 2050 C CD . LYS A 1 267 ? -7.529 -53.451 -44.277 1.00 51.25 ? 267 LYS A CD 1 ATOM 2051 C CE . LYS A 1 267 ? -7.900 -54.656 -43.416 1.00 52.94 ? 267 LYS A CE 1 ATOM 2052 N NZ . LYS A 1 267 ? -7.736 -55.927 -44.174 1.00 54.19 ? 267 LYS A NZ 1 ATOM 2053 N N . ASP A 1 268 ? -11.832 -51.428 -44.809 1.00 48.32 ? 268 ASP A N 1 ATOM 2054 C CA . ASP A 1 268 ? -13.161 -50.852 -44.766 1.00 49.41 ? 268 ASP A CA 1 ATOM 2055 C C . ASP A 1 268 ? -13.363 -50.113 -43.456 1.00 48.62 ? 268 ASP A C 1 ATOM 2056 O O . ASP A 1 268 ? -12.956 -50.598 -42.397 1.00 48.03 ? 268 ASP A O 1 ATOM 2057 C CB . ASP A 1 268 ? -14.221 -51.952 -44.823 1.00 50.56 ? 268 ASP A CB 1 ATOM 2058 C CG . ASP A 1 268 ? -14.906 -52.033 -46.179 1.00 55.55 ? 268 ASP A CG 1 ATOM 2059 O OD1 . ASP A 1 268 ? -14.322 -52.622 -47.126 1.00 57.61 ? 268 ASP A OD1 1 ATOM 2060 O OD2 . ASP A 1 268 ? -16.043 -51.500 -46.294 1.00 61.65 ? 268 ASP A OD2 1 ATOM 2061 N N . PRO A 1 269 ? -14.046 -48.972 -43.514 1.00 48.11 ? 269 PRO A N 1 ATOM 2062 C CA . PRO A 1 269 ? -14.377 -48.269 -42.304 1.00 47.64 ? 269 PRO A CA 1 ATOM 2063 C C . PRO A 1 269 ? -14.640 -49.253 -41.181 1.00 47.35 ? 269 PRO A C 1 ATOM 2064 O O . PRO A 1 269 ? -14.094 -49.095 -40.098 1.00 47.09 ? 269 PRO A O 1 ATOM 2065 C CB . PRO A 1 269 ? -15.641 -47.532 -42.702 1.00 47.61 ? 269 PRO A CB 1 ATOM 2066 C CG . PRO A 1 269 ? -15.400 -47.182 -44.125 1.00 47.51 ? 269 PRO A CG 1 ATOM 2067 C CD . PRO A 1 269 ? -14.502 -48.238 -44.704 1.00 48.10 ? 269 PRO A CD 1 ATOM 2068 N N . GLN A 1 270 ? -15.429 -50.297 -41.441 1.00 47.14 ? 270 GLN A N 1 ATOM 2069 C CA . GLN A 1 270 ? -15.854 -51.218 -40.372 1.00 46.81 ? 270 GLN A CA 1 ATOM 2070 C C . GLN A 1 270 ? -14.777 -52.043 -39.728 1.00 45.63 ? 270 GLN A C 1 ATOM 2071 O O . GLN A 1 270 ? -14.902 -52.382 -38.563 1.00 45.62 ? 270 GLN A O 1 ATOM 2072 C CB . GLN A 1 270 ? -16.953 -52.167 -40.850 1.00 47.69 ? 270 GLN A CB 1 ATOM 2073 C CG . GLN A 1 270 ? -18.349 -51.708 -40.546 1.00 51.74 ? 270 GLN A CG 1 ATOM 2074 C CD . GLN A 1 270 ? -18.597 -51.440 -39.049 1.00 59.23 ? 270 GLN A CD 1 ATOM 2075 O OE1 . GLN A 1 270 ? -18.093 -52.156 -38.149 1.00 59.03 ? 270 GLN A OE1 1 ATOM 2076 N NE2 . GLN A 1 270 ? -19.383 -50.389 -38.781 1.00 60.44 ? 270 GLN A NE2 1 ATOM 2077 N N . GLU A 1 271 ? -13.752 -52.436 -40.474 1.00 45.29 ? 271 GLU A N 1 ATOM 2078 C CA . GLU A 1 271 ? -12.701 -53.271 -39.873 1.00 45.58 ? 271 GLU A CA 1 ATOM 2079 C C . GLU A 1 271 ? -11.838 -52.423 -38.932 1.00 44.38 ? 271 GLU A C 1 ATOM 2080 O O . GLU A 1 271 ? -11.264 -52.913 -37.953 1.00 44.39 ? 271 GLU A O 1 ATOM 2081 C CB . GLU A 1 271 ? -11.771 -53.867 -40.927 1.00 45.83 ? 271 GLU A CB 1 ATOM 2082 C CG . GLU A 1 271 ? -12.393 -54.750 -42.004 1.00 50.91 ? 271 GLU A CG 1 ATOM 2083 C CD . GLU A 1 271 ? -11.349 -55.096 -43.091 1.00 56.25 ? 271 GLU A CD 1 ATOM 2084 O OE1 . GLU A 1 271 ? -10.325 -55.760 -42.727 1.00 55.45 ? 271 GLU A OE1 1 ATOM 2085 O OE2 . GLU A 1 271 ? -11.542 -54.667 -44.279 1.00 57.02 ? 271 GLU A OE2 1 ATOM 2086 N N . ILE A 1 272 ? -11.684 -51.159 -39.299 1.00 43.02 ? 272 ILE A N 1 ATOM 2087 C CA . ILE A 1 272 ? -10.995 -50.199 -38.457 1.00 41.67 ? 272 ILE A CA 1 ATOM 2088 C C . ILE A 1 272 ? -11.807 -50.001 -37.178 1.00 40.72 ? 272 ILE A C 1 ATOM 2089 O O . ILE A 1 272 ? -11.288 -50.224 -36.093 1.00 41.34 ? 272 ILE A O 1 ATOM 2090 C CB . ILE A 1 272 ? -10.782 -48.916 -39.241 1.00 41.31 ? 272 ILE A CB 1 ATOM 2091 C CG1 . ILE A 1 272 ? -9.645 -49.137 -40.245 1.00 40.26 ? 272 ILE A CG1 1 ATOM 2092 C CG2 . ILE A 1 272 ? -10.413 -47.755 -38.323 1.00 42.86 ? 272 ILE A CG2 1 ATOM 2093 C CD1 . ILE A 1 272 ? -9.593 -48.113 -41.380 1.00 37.23 ? 272 ILE A CD1 1 ATOM 2094 N N . LEU A 1 273 ? -13.092 -49.681 -37.297 1.00 40.26 ? 273 LEU A N 1 ATOM 2095 C CA . LEU A 1 273 ? -13.909 -49.459 -36.116 1.00 40.75 ? 273 LEU A CA 1 ATOM 2096 C C . LEU A 1 273 ? -13.878 -50.643 -35.178 1.00 41.50 ? 273 LEU A C 1 ATOM 2097 O O . LEU A 1 273 ? -13.798 -50.472 -33.944 1.00 40.63 ? 273 LEU A O 1 ATOM 2098 C CB . LEU A 1 273 ? -15.344 -49.116 -36.466 1.00 40.05 ? 273 LEU A CB 1 ATOM 2099 C CG . LEU A 1 273 ? -15.499 -47.794 -37.224 1.00 41.81 ? 273 LEU A CG 1 ATOM 2100 C CD1 . LEU A 1 273 ? -16.887 -47.672 -37.787 1.00 39.94 ? 273 LEU A CD1 1 ATOM 2101 C CD2 . LEU A 1 273 ? -15.189 -46.571 -36.308 1.00 42.47 ? 273 LEU A CD2 1 ATOM 2102 N N . LEU A 1 274 ? -13.940 -51.849 -35.757 1.00 41.87 ? 274 LEU A N 1 ATOM 2103 C CA . LEU A 1 274 ? -14.049 -53.059 -34.962 1.00 42.50 ? 274 LEU A CA 1 ATOM 2104 C C . LEU A 1 274 ? -12.811 -53.355 -34.160 1.00 41.79 ? 274 LEU A C 1 ATOM 2105 O O . LEU A 1 274 ? -12.882 -53.978 -33.092 1.00 41.68 ? 274 LEU A O 1 ATOM 2106 C CB . LEU A 1 274 ? -14.399 -54.259 -35.837 1.00 44.07 ? 274 LEU A CB 1 ATOM 2107 C CG . LEU A 1 274 ? -15.902 -54.521 -35.797 1.00 47.93 ? 274 LEU A CG 1 ATOM 2108 C CD1 . LEU A 1 274 ? -16.667 -53.338 -35.153 1.00 52.36 ? 274 LEU A CD1 1 ATOM 2109 C CD2 . LEU A 1 274 ? -16.392 -54.799 -37.208 1.00 51.00 ? 274 LEU A CD2 1 ATOM 2110 N N . ASN A 1 275 ? -11.655 -52.923 -34.654 1.00 41.16 ? 275 ASN A N 1 ATOM 2111 C CA . ASN A 1 275 ? -10.427 -53.185 -33.910 1.00 40.24 ? 275 ASN A CA 1 ATOM 2112 C C . ASN A 1 275 ? -9.924 -52.074 -32.965 1.00 39.85 ? 275 ASN A C 1 ATOM 2113 O O . ASN A 1 275 ? -8.985 -52.284 -32.193 1.00 40.14 ? 275 ASN A O 1 ATOM 2114 C CB . ASN A 1 275 ? -9.353 -53.672 -34.880 1.00 39.78 ? 275 ASN A CB 1 ATOM 2115 C CG . ASN A 1 275 ? -9.680 -55.033 -35.406 1.00 38.86 ? 275 ASN A CG 1 ATOM 2116 O OD1 . ASN A 1 275 ? -10.300 -55.173 -36.443 1.00 38.49 ? 275 ASN A OD1 1 ATOM 2117 N ND2 . ASN A 1 275 ? -9.369 -56.038 -34.630 1.00 37.03 ? 275 ASN A ND2 1 ATOM 2118 N N . GLU A 1 276 ? -10.557 -50.906 -33.039 1.00 39.36 ? 276 GLU A N 1 ATOM 2119 C CA . GLU A 1 276 ? -10.221 -49.754 -32.194 1.00 38.52 ? 276 GLU A CA 1 ATOM 2120 C C . GLU A 1 276 ? -10.178 -50.127 -30.727 1.00 39.45 ? 276 GLU A C 1 ATOM 2121 O O . GLU A 1 276 ? -9.207 -49.801 -30.038 1.00 40.50 ? 276 GLU A O 1 ATOM 2122 C CB . GLU A 1 276 ? -11.247 -48.633 -32.399 1.00 37.90 ? 276 GLU A CB 1 ATOM 2123 C CG . GLU A 1 276 ? -10.937 -47.711 -33.576 1.00 36.83 ? 276 GLU A CG 1 ATOM 2124 C CD . GLU A 1 276 ? -11.963 -46.601 -33.765 1.00 38.10 ? 276 GLU A CD 1 ATOM 2125 O OE1 . GLU A 1 276 ? -12.969 -46.496 -33.005 1.00 38.29 ? 276 GLU A OE1 1 ATOM 2126 O OE2 . GLU A 1 276 ? -11.785 -45.827 -34.721 1.00 39.44 ? 276 GLU A OE2 1 ATOM 2127 N N . ALA A 1 277 ? -11.231 -50.787 -30.239 1.00 39.99 ? 277 ALA A N 1 ATOM 2128 C CA . ALA A 1 277 ? -11.361 -51.128 -28.818 1.00 41.63 ? 277 ALA A CA 1 ATOM 2129 C C . ALA A 1 277 ? -10.199 -51.951 -28.285 1.00 43.06 ? 277 ALA A C 1 ATOM 2130 O O . ALA A 1 277 ? -9.886 -51.902 -27.106 1.00 43.64 ? 277 ALA A O 1 ATOM 2131 C CB . ALA A 1 277 ? -12.639 -51.841 -28.569 1.00 41.08 ? 277 ALA A CB 1 ATOM 2132 N N . PHE A 1 278 ? -9.528 -52.681 -29.163 1.00 45.00 ? 278 PHE A N 1 ATOM 2133 C CA . PHE A 1 278 ? -8.479 -53.615 -28.722 1.00 46.07 ? 278 PHE A CA 1 ATOM 2134 C C . PHE A 1 278 ? -7.048 -53.113 -28.877 1.00 46.43 ? 278 PHE A C 1 ATOM 2135 O O . PHE A 1 278 ? -6.109 -53.801 -28.442 1.00 46.85 ? 278 PHE A O 1 ATOM 2136 C CB . PHE A 1 278 ? -8.596 -54.931 -29.481 1.00 46.24 ? 278 PHE A CB 1 ATOM 2137 C CG . PHE A 1 278 ? -9.986 -55.429 -29.576 1.00 48.25 ? 278 PHE A CG 1 ATOM 2138 C CD1 . PHE A 1 278 ? -10.608 -55.975 -28.466 1.00 50.86 ? 278 PHE A CD1 1 ATOM 2139 C CD2 . PHE A 1 278 ? -10.681 -55.340 -30.765 1.00 50.40 ? 278 PHE A CD2 1 ATOM 2140 C CE1 . PHE A 1 278 ? -11.923 -56.437 -28.543 1.00 52.48 ? 278 PHE A CE1 1 ATOM 2141 C CE2 . PHE A 1 278 ? -11.967 -55.792 -30.851 1.00 52.06 ? 278 PHE A CE2 1 ATOM 2142 C CZ . PHE A 1 278 ? -12.595 -56.345 -29.729 1.00 52.74 ? 278 PHE A CZ 1 ATOM 2143 N N . VAL A 1 279 ? -6.855 -51.939 -29.477 1.00 46.31 ? 279 VAL A N 1 ATOM 2144 C CA . VAL A 1 279 ? -5.499 -51.453 -29.660 1.00 46.42 ? 279 VAL A CA 1 ATOM 2145 C C . VAL A 1 279 ? -4.786 -51.289 -28.312 1.00 47.10 ? 279 VAL A C 1 ATOM 2146 O O . VAL A 1 279 ? -3.622 -50.917 -28.266 1.00 47.60 ? 279 VAL A O 1 ATOM 2147 C CB . VAL A 1 279 ? -5.449 -50.120 -30.432 1.00 46.59 ? 279 VAL A CB 1 ATOM 2148 C CG1 . VAL A 1 279 ? -5.891 -50.320 -31.869 1.00 44.43 ? 279 VAL A CG1 1 ATOM 2149 C CG2 . VAL A 1 279 ? -6.305 -49.084 -29.743 1.00 45.12 ? 279 VAL A CG2 1 ATOM 2150 N N . VAL A 1 280 ? -5.485 -51.589 -27.226 1.00 47.65 ? 280 VAL A N 1 ATOM 2151 C CA . VAL A 1 280 ? -4.998 -51.319 -25.882 1.00 48.50 ? 280 VAL A CA 1 ATOM 2152 C C . VAL A 1 280 ? -5.239 -52.592 -25.003 1.00 50.01 ? 280 VAL A C 1 ATOM 2153 O O . VAL A 1 280 ? -6.324 -53.215 -25.071 1.00 50.47 ? 280 VAL A O 1 ATOM 2154 C CB . VAL A 1 280 ? -5.742 -50.048 -25.331 1.00 48.45 ? 280 VAL A CB 1 ATOM 2155 C CG1 . VAL A 1 280 ? -6.775 -50.414 -24.297 1.00 46.14 ? 280 VAL A CG1 1 ATOM 2156 C CG2 . VAL A 1 280 ? -4.765 -48.998 -24.797 1.00 48.36 ? 280 VAL A CG2 1 ATOM 2157 N N . PRO A 1 281 ? -4.235 -52.993 -24.192 1.00 50.66 ? 281 PRO A N 1 ATOM 2158 C CA . PRO A 1 281 ? -4.335 -54.233 -23.407 1.00 51.26 ? 281 PRO A CA 1 ATOM 2159 C C . PRO A 1 281 ? -5.494 -54.215 -22.426 1.00 51.80 ? 281 PRO A C 1 ATOM 2160 O O . PRO A 1 281 ? -6.216 -55.197 -22.319 1.00 51.80 ? 281 PRO A O 1 ATOM 2161 C CB . PRO A 1 281 ? -3.004 -54.296 -22.649 1.00 51.55 ? 281 PRO A CB 1 ATOM 2162 C CG . PRO A 1 281 ? -2.490 -52.877 -22.646 1.00 51.30 ? 281 PRO A CG 1 ATOM 2163 C CD . PRO A 1 281 ? -2.964 -52.288 -23.952 1.00 51.39 ? 281 PRO A CD 1 ATOM 2164 N N . TYR A 1 282 ? -5.672 -53.124 -21.693 1.00 51.96 ? 282 TYR A N 1 ATOM 2165 C CA . TYR A 1 282 ? -6.866 -53.000 -20.864 1.00 52.43 ? 282 TYR A CA 1 ATOM 2166 C C . TYR A 1 282 ? -7.421 -51.593 -21.029 1.00 51.29 ? 282 TYR A C 1 ATOM 2167 O O . TYR A 1 282 ? -6.667 -50.625 -21.078 1.00 52.25 ? 282 TYR A O 1 ATOM 2168 C CB . TYR A 1 282 ? -6.568 -53.320 -19.387 1.00 53.58 ? 282 TYR A CB 1 ATOM 2169 C CG . TYR A 1 282 ? -5.234 -52.776 -18.943 1.00 58.14 ? 282 TYR A CG 1 ATOM 2170 C CD1 . TYR A 1 282 ? -4.202 -53.629 -18.537 1.00 62.54 ? 282 TYR A CD1 1 ATOM 2171 C CD2 . TYR A 1 282 ? -4.982 -51.403 -18.986 1.00 62.11 ? 282 TYR A CD2 1 ATOM 2172 C CE1 . TYR A 1 282 ? -2.953 -53.110 -18.156 1.00 65.40 ? 282 TYR A CE1 1 ATOM 2173 C CE2 . TYR A 1 282 ? -3.743 -50.874 -18.613 1.00 65.21 ? 282 TYR A CE2 1 ATOM 2174 C CZ . TYR A 1 282 ? -2.736 -51.726 -18.202 1.00 65.95 ? 282 TYR A CZ 1 ATOM 2175 O OH . TYR A 1 282 ? -1.523 -51.175 -17.844 1.00 67.47 ? 282 TYR A OH 1 ATOM 2176 N N . GLY A 1 283 ? -8.733 -51.475 -21.152 1.00 49.34 ? 283 GLY A N 1 ATOM 2177 C CA . GLY A 1 283 ? -9.328 -50.168 -21.277 1.00 46.05 ? 283 GLY A CA 1 ATOM 2178 C C . GLY A 1 283 ? -10.167 -49.873 -20.051 1.00 43.65 ? 283 GLY A C 1 ATOM 2179 O O . GLY A 1 283 ? -10.333 -50.713 -19.162 1.00 43.75 ? 283 GLY A O 1 ATOM 2180 N N . THR A 1 284 ? -10.731 -48.680 -19.999 1.00 40.68 ? 284 THR A N 1 ATOM 2181 C CA . THR A 1 284 ? -11.677 -48.393 -18.948 1.00 37.71 ? 284 THR A CA 1 ATOM 2182 C C . THR A 1 284 ? -12.904 -47.819 -19.668 1.00 36.65 ? 284 THR A C 1 ATOM 2183 O O . THR A 1 284 ? -12.840 -47.576 -20.879 1.00 34.73 ? 284 THR A O 1 ATOM 2184 C CB . THR A 1 284 ? -11.072 -47.383 -17.958 1.00 37.46 ? 284 THR A CB 1 ATOM 2185 O OG1 . THR A 1 284 ? -10.807 -46.187 -18.668 1.00 37.51 ? 284 THR A OG1 1 ATOM 2186 C CG2 . THR A 1 284 ? -9.732 -47.889 -17.401 1.00 35.02 ? 284 THR A CG2 1 ATOM 2187 N N . PRO A 1 285 ? -14.007 -47.595 -18.927 1.00 34.98 ? 285 PRO A N 1 ATOM 2188 C CA . PRO A 1 285 ? -15.183 -46.933 -19.485 1.00 34.80 ? 285 PRO A CA 1 ATOM 2189 C C . PRO A 1 285 ? -14.861 -45.507 -19.917 1.00 35.02 ? 285 PRO A C 1 ATOM 2190 O O . PRO A 1 285 ? -15.727 -44.817 -20.448 1.00 36.02 ? 285 PRO A O 1 ATOM 2191 C CB . PRO A 1 285 ? -16.135 -46.856 -18.310 1.00 34.52 ? 285 PRO A CB 1 ATOM 2192 C CG . PRO A 1 285 ? -15.653 -48.008 -17.343 1.00 34.07 ? 285 PRO A CG 1 ATOM 2193 C CD . PRO A 1 285 ? -14.174 -47.986 -17.509 1.00 35.15 ? 285 PRO A CD 1 ATOM 2194 N N . LEU A 1 286 ? -13.643 -45.052 -19.651 1.00 34.28 ? 286 LEU A N 1 ATOM 2195 C CA . LEU A 1 286 ? -13.249 -43.689 -19.970 1.00 33.95 ? 286 LEU A CA 1 ATOM 2196 C C . LEU A 1 286 ? -12.107 -43.701 -20.948 1.00 33.65 ? 286 LEU A C 1 ATOM 2197 O O . LEU A 1 286 ? -11.504 -42.681 -21.194 1.00 34.68 ? 286 LEU A O 1 ATOM 2198 C CB . LEU A 1 286 ? -12.829 -42.945 -18.719 1.00 34.20 ? 286 LEU A CB 1 ATOM 2199 C CG . LEU A 1 286 ? -14.026 -42.222 -18.101 1.00 34.89 ? 286 LEU A CG 1 ATOM 2200 C CD1 . LEU A 1 286 ? -13.811 -41.964 -16.623 1.00 33.10 ? 286 LEU A CD1 1 ATOM 2201 C CD2 . LEU A 1 286 ? -14.187 -40.931 -18.838 1.00 35.83 ? 286 LEU A CD2 1 ATOM 2202 N N . SER A 1 287 ? -11.825 -44.858 -21.530 1.00 32.42 ? 287 SER A N 1 ATOM 2203 C CA . SER A 1 287 ? -10.746 -44.977 -22.525 1.00 31.34 ? 287 SER A CA 1 ATOM 2204 C C . SER A 1 287 ? -10.913 -44.069 -23.730 1.00 29.61 ? 287 SER A C 1 ATOM 2205 O O . SER A 1 287 ? -12.000 -43.962 -24.299 1.00 29.09 ? 287 SER A O 1 ATOM 2206 C CB . SER A 1 287 ? -10.665 -46.424 -23.044 1.00 31.63 ? 287 SER A CB 1 ATOM 2207 O OG . SER A 1 287 ? -9.895 -47.225 -22.164 1.00 34.32 ? 287 SER A OG 1 ATOM 2208 N N . VAL A 1 288 ? -9.806 -43.480 -24.148 1.00 28.03 ? 288 VAL A N 1 ATOM 2209 C CA . VAL A 1 288 ? -9.763 -42.617 -25.314 1.00 26.12 ? 288 VAL A CA 1 ATOM 2210 C C . VAL A 1 288 ? -8.624 -43.195 -26.129 1.00 27.11 ? 288 VAL A C 1 ATOM 2211 O O . VAL A 1 288 ? -7.482 -42.774 -25.998 1.00 26.38 ? 288 VAL A O 1 ATOM 2212 C CB . VAL A 1 288 ? -9.503 -41.131 -24.936 1.00 25.65 ? 288 VAL A CB 1 ATOM 2213 C CG1 . VAL A 1 288 ? -9.040 -40.323 -26.111 1.00 22.79 ? 288 VAL A CG1 1 ATOM 2214 C CG2 . VAL A 1 288 ? -10.806 -40.474 -24.411 1.00 20.14 ? 288 VAL A CG2 1 ATOM 2215 N N . ASN A 1 289 ? -8.925 -44.173 -26.981 1.00 27.60 ? 289 ASN A N 1 ATOM 2216 C CA . ASN A 1 289 ? -7.864 -44.912 -27.630 1.00 27.50 ? 289 ASN A CA 1 ATOM 2217 C C . ASN A 1 289 ? -7.186 -44.090 -28.668 1.00 27.08 ? 289 ASN A C 1 ATOM 2218 O O . ASN A 1 289 ? -5.999 -44.175 -28.801 1.00 27.14 ? 289 ASN A O 1 ATOM 2219 C CB . ASN A 1 289 ? -8.364 -46.240 -28.159 1.00 28.88 ? 289 ASN A CB 1 ATOM 2220 C CG . ASN A 1 289 ? -8.590 -47.252 -27.013 1.00 33.19 ? 289 ASN A CG 1 ATOM 2221 O OD1 . ASN A 1 289 ? -9.502 -48.070 -27.054 1.00 37.07 ? 289 ASN A OD1 1 ATOM 2222 N ND2 . ASN A 1 289 ? -7.757 -47.160 -25.980 1.00 36.19 ? 289 ASN A ND2 1 ATOM 2223 N N . PHE A 1 290 ? -7.931 -43.252 -29.372 1.00 27.37 ? 290 PHE A N 1 ATOM 2224 C CA . PHE A 1 290 ? -7.328 -42.406 -30.375 1.00 27.82 ? 290 PHE A CA 1 ATOM 2225 C C . PHE A 1 290 ? -7.701 -40.967 -30.076 1.00 27.87 ? 290 PHE A C 1 ATOM 2226 O O . PHE A 1 290 ? -8.836 -40.590 -30.305 1.00 28.34 ? 290 PHE A O 1 ATOM 2227 C CB . PHE A 1 290 ? -7.779 -42.843 -31.773 1.00 27.80 ? 290 PHE A CB 1 ATOM 2228 C CG . PHE A 1 290 ? -7.216 -44.187 -32.166 1.00 30.05 ? 290 PHE A CG 1 ATOM 2229 C CD1 . PHE A 1 290 ? -5.934 -44.281 -32.692 1.00 29.37 ? 290 PHE A CD1 1 ATOM 2230 C CD2 . PHE A 1 290 ? -7.944 -45.366 -31.898 1.00 33.33 ? 290 PHE A CD2 1 ATOM 2231 C CE1 . PHE A 1 290 ? -5.391 -45.511 -32.992 1.00 31.85 ? 290 PHE A CE1 1 ATOM 2232 C CE2 . PHE A 1 290 ? -7.420 -46.607 -32.211 1.00 31.50 ? 290 PHE A CE2 1 ATOM 2233 C CZ . PHE A 1 290 ? -6.143 -46.690 -32.757 1.00 28.12 ? 290 PHE A CZ 1 ATOM 2234 N N . GLY A 1 291 ? -6.749 -40.191 -29.543 1.00 28.20 ? 291 GLY A N 1 ATOM 2235 C CA . GLY A 1 291 ? -7.005 -38.815 -29.096 1.00 28.04 ? 291 GLY A CA 1 ATOM 2236 C C . GLY A 1 291 ? -5.973 -37.835 -29.593 1.00 28.25 ? 291 GLY A C 1 ATOM 2237 O O . GLY A 1 291 ? -5.120 -38.193 -30.403 1.00 28.36 ? 291 GLY A O 1 ATOM 2238 N N . PRO A 1 292 ? -6.061 -36.576 -29.126 1.00 27.64 ? 292 PRO A N 1 ATOM 2239 C CA . PRO A 1 292 ? -5.065 -35.546 -29.462 1.00 27.38 ? 292 PRO A CA 1 ATOM 2240 C C . PRO A 1 292 ? -3.653 -35.995 -29.141 1.00 26.32 ? 292 PRO A C 1 ATOM 2241 O O . PRO A 1 292 ? -3.426 -36.697 -28.153 1.00 25.42 ? 292 PRO A O 1 ATOM 2242 C CB . PRO A 1 292 ? -5.466 -34.370 -28.531 1.00 26.11 ? 292 PRO A CB 1 ATOM 2243 C CG . PRO A 1 292 ? -6.935 -34.545 -28.345 1.00 27.33 ? 292 PRO A CG 1 ATOM 2244 C CD . PRO A 1 292 ? -7.214 -36.018 -28.396 1.00 25.99 ? 292 PRO A CD 1 ATOM 2245 N N . THR A 1 293 ? -2.691 -35.585 -29.944 1.00 26.58 ? 293 THR A N 1 ATOM 2246 C CA . THR A 1 293 ? -1.303 -35.908 -29.624 1.00 26.85 ? 293 THR A CA 1 ATOM 2247 C C . THR A 1 293 ? -0.505 -34.669 -29.901 1.00 27.56 ? 293 THR A C 1 ATOM 2248 O O . THR A 1 293 ? -0.975 -33.750 -30.589 1.00 29.17 ? 293 THR A O 1 ATOM 2249 C CB . THR A 1 293 ? -0.655 -37.048 -30.488 1.00 27.64 ? 293 THR A CB 1 ATOM 2250 O OG1 . THR A 1 293 ? -0.891 -36.815 -31.895 1.00 25.29 ? 293 THR A OG1 1 ATOM 2251 C CG2 . THR A 1 293 ? -1.158 -38.343 -30.101 1.00 28.06 ? 293 THR A CG2 1 ATOM 2252 N N . VAL A 1 294 ? 0.722 -34.678 -29.430 1.00 26.91 ? 294 VAL A N 1 ATOM 2253 C CA . VAL A 1 294 ? 1.595 -33.554 -29.652 1.00 28.25 ? 294 VAL A CA 1 ATOM 2254 C C . VAL A 1 294 ? 2.197 -33.861 -31.011 1.00 28.67 ? 294 VAL A C 1 ATOM 2255 O O . VAL A 1 294 ? 3.024 -34.739 -31.119 1.00 29.37 ? 294 VAL A O 1 ATOM 2256 C CB . VAL A 1 294 ? 2.678 -33.482 -28.504 1.00 28.19 ? 294 VAL A CB 1 ATOM 2257 C CG1 . VAL A 1 294 ? 3.783 -32.458 -28.813 1.00 27.70 ? 294 VAL A CG1 1 ATOM 2258 C CG2 . VAL A 1 294 ? 1.987 -33.162 -27.196 1.00 28.16 ? 294 VAL A CG2 1 ATOM 2259 N N . ASP A 1 295 ? 1.740 -33.168 -32.042 1.00 28.76 ? 295 ASP A N 1 ATOM 2260 C CA . ASP A 1 295 ? 2.079 -33.534 -33.384 1.00 30.17 ? 295 ASP A CA 1 ATOM 2261 C C . ASP A 1 295 ? 3.126 -32.570 -33.980 1.00 31.19 ? 295 ASP A C 1 ATOM 2262 O O . ASP A 1 295 ? 3.529 -32.759 -35.118 1.00 32.07 ? 295 ASP A O 1 ATOM 2263 C CB . ASP A 1 295 ? 0.810 -33.472 -34.230 1.00 29.29 ? 295 ASP A CB 1 ATOM 2264 C CG . ASP A 1 295 ? 0.215 -32.093 -34.227 1.00 30.31 ? 295 ASP A CG 1 ATOM 2265 O OD1 . ASP A 1 295 ? 0.669 -31.283 -33.366 1.00 32.24 ? 295 ASP A OD1 1 ATOM 2266 O OD2 . ASP A 1 295 ? -0.655 -31.770 -35.074 1.00 29.66 ? 295 ASP A OD2 1 ATOM 2267 N N . GLY A 1 296 ? 3.550 -31.537 -33.244 1.00 30.32 ? 296 GLY A N 1 ATOM 2268 C CA . GLY A 1 296 ? 4.434 -30.517 -33.789 1.00 29.81 ? 296 GLY A CA 1 ATOM 2269 C C . GLY A 1 296 ? 3.754 -29.598 -34.785 1.00 31.42 ? 296 GLY A C 1 ATOM 2270 O O . GLY A 1 296 ? 4.408 -28.834 -35.524 1.00 32.03 ? 296 GLY A O 1 ATOM 2271 N N . ASP A 1 297 ? 2.424 -29.636 -34.843 1.00 30.63 ? 297 ASP A N 1 ATOM 2272 C CA . ASP A 1 297 ? 1.746 -28.847 -35.861 1.00 29.37 ? 297 ASP A CA 1 ATOM 2273 C C . ASP A 1 297 ? 0.597 -28.146 -35.169 1.00 29.15 ? 297 ASP A C 1 ATOM 2274 O O . ASP A 1 297 ? 0.723 -26.979 -34.826 1.00 29.47 ? 297 ASP A O 1 ATOM 2275 C CB . ASP A 1 297 ? 1.289 -29.781 -37.003 1.00 28.65 ? 297 ASP A CB 1 ATOM 2276 C CG . ASP A 1 297 ? 0.745 -29.035 -38.184 1.00 30.85 ? 297 ASP A CG 1 ATOM 2277 O OD1 . ASP A 1 297 ? 0.675 -27.805 -38.139 1.00 32.84 ? 297 ASP A OD1 1 ATOM 2278 O OD2 . ASP A 1 297 ? 0.375 -29.670 -39.189 1.00 35.77 ? 297 ASP A OD2 1 ATOM 2279 N N . PHE A 1 298 ? -0.502 -28.865 -34.918 1.00 27.87 ? 298 PHE A N 1 ATOM 2280 C CA . PHE A 1 298 ? -1.595 -28.303 -34.146 1.00 27.52 ? 298 PHE A CA 1 ATOM 2281 C C . PHE A 1 298 ? -1.094 -27.970 -32.727 1.00 28.11 ? 298 PHE A C 1 ATOM 2282 O O . PHE A 1 298 ? -1.382 -26.895 -32.195 1.00 27.82 ? 298 PHE A O 1 ATOM 2283 C CB . PHE A 1 298 ? -2.751 -29.285 -34.012 1.00 25.68 ? 298 PHE A CB 1 ATOM 2284 C CG . PHE A 1 298 ? -3.985 -28.662 -33.410 1.00 26.09 ? 298 PHE A CG 1 ATOM 2285 C CD1 . PHE A 1 298 ? -4.248 -28.771 -32.064 1.00 23.23 ? 298 PHE A CD1 1 ATOM 2286 C CD2 . PHE A 1 298 ? -4.864 -27.942 -34.194 1.00 24.75 ? 298 PHE A CD2 1 ATOM 2287 C CE1 . PHE A 1 298 ? -5.391 -28.182 -31.490 1.00 23.51 ? 298 PHE A CE1 1 ATOM 2288 C CE2 . PHE A 1 298 ? -6.000 -27.335 -33.634 1.00 23.76 ? 298 PHE A CE2 1 ATOM 2289 C CZ . PHE A 1 298 ? -6.252 -27.467 -32.277 1.00 25.60 ? 298 PHE A CZ 1 ATOM 2290 N N . LEU A 1 299 ? -0.347 -28.913 -32.153 1.00 28.05 ? 299 LEU A N 1 ATOM 2291 C CA . LEU A 1 299 ? 0.121 -28.850 -30.793 1.00 29.06 ? 299 LEU A CA 1 ATOM 2292 C C . LEU A 1 299 ? 1.628 -28.871 -30.866 1.00 29.64 ? 299 LEU A C 1 ATOM 2293 O O . LEU A 1 299 ? 2.237 -29.879 -31.237 1.00 28.77 ? 299 LEU A O 1 ATOM 2294 C CB . LEU A 1 299 ? -0.320 -30.097 -30.083 1.00 29.04 ? 299 LEU A CB 1 ATOM 2295 C CG . LEU A 1 299 ? -1.151 -30.013 -28.841 1.00 33.34 ? 299 LEU A CG 1 ATOM 2296 C CD1 . LEU A 1 299 ? -1.385 -31.416 -28.271 1.00 35.56 ? 299 LEU A CD1 1 ATOM 2297 C CD2 . LEU A 1 299 ? -0.413 -29.093 -27.843 1.00 38.53 ? 299 LEU A CD2 1 ATOM 2298 N N . THR A 1 300 ? 2.256 -27.749 -30.536 1.00 30.36 ? 300 THR A N 1 ATOM 2299 C CA . THR A 1 300 ? 3.701 -27.678 -30.613 1.00 31.01 ? 300 THR A CA 1 ATOM 2300 C C . THR A 1 300 ? 4.483 -28.228 -29.426 1.00 30.19 ? 300 THR A C 1 ATOM 2301 O O . THR A 1 300 ? 5.651 -28.443 -29.565 1.00 31.20 ? 300 THR A O 1 ATOM 2302 C CB . THR A 1 300 ? 4.129 -26.262 -30.873 1.00 32.22 ? 300 THR A CB 1 ATOM 2303 O OG1 . THR A 1 300 ? 3.969 -25.514 -29.657 1.00 34.70 ? 300 THR A OG1 1 ATOM 2304 C CG2 . THR A 1 300 ? 3.193 -25.652 -31.938 1.00 32.60 ? 300 THR A CG2 1 ATOM 2305 N N . ASP A 1 301 ? 3.891 -28.511 -28.272 1.00 29.33 ? 301 ASP A N 1 ATOM 2306 C CA . ASP A 1 301 ? 4.740 -28.987 -27.176 1.00 28.37 ? 301 ASP A CA 1 ATOM 2307 C C . ASP A 1 301 ? 3.777 -29.648 -26.213 1.00 27.69 ? 301 ASP A C 1 ATOM 2308 O O . ASP A 1 301 ? 2.609 -29.521 -26.379 1.00 27.22 ? 301 ASP A O 1 ATOM 2309 C CB . ASP A 1 301 ? 5.487 -27.781 -26.570 1.00 28.05 ? 301 ASP A CB 1 ATOM 2310 C CG . ASP A 1 301 ? 6.681 -28.166 -25.632 1.00 30.57 ? 301 ASP A CG 1 ATOM 2311 O OD1 . ASP A 1 301 ? 7.451 -27.227 -25.266 1.00 32.22 ? 301 ASP A OD1 1 ATOM 2312 O OD2 . ASP A 1 301 ? 6.861 -29.340 -25.241 1.00 26.95 ? 301 ASP A OD2 1 ATOM 2313 N N . MET A 1 302 ? 4.246 -30.398 -25.244 1.00 27.59 ? 302 MET A N 1 ATOM 2314 C CA . MET A 1 302 ? 3.312 -31.042 -24.359 1.00 28.65 ? 302 MET A CA 1 ATOM 2315 C C . MET A 1 302 ? 2.450 -29.963 -23.756 1.00 28.22 ? 302 MET A C 1 ATOM 2316 O O . MET A 1 302 ? 2.978 -28.966 -23.293 1.00 28.39 ? 302 MET A O 1 ATOM 2317 C CB . MET A 1 302 ? 4.089 -31.820 -23.326 1.00 29.46 ? 302 MET A CB 1 ATOM 2318 C CG . MET A 1 302 ? 4.975 -32.857 -24.019 1.00 33.08 ? 302 MET A CG 1 ATOM 2319 S SD . MET A 1 302 ? 6.049 -33.651 -22.834 1.00 45.92 ? 302 MET A SD 1 ATOM 2320 C CE . MET A 1 302 ? 4.764 -34.307 -21.705 1.00 43.88 ? 302 MET A CE 1 ATOM 2321 N N . PRO A 1 303 ? 1.112 -30.110 -23.842 1.00 28.40 ? 303 PRO A N 1 ATOM 2322 C CA . PRO A 1 303 ? 0.315 -28.911 -23.513 1.00 27.76 ? 303 PRO A CA 1 ATOM 2323 C C . PRO A 1 303 ? 0.404 -28.542 -22.026 1.00 27.78 ? 303 PRO A C 1 ATOM 2324 O O . PRO A 1 303 ? 0.130 -27.417 -21.660 1.00 29.10 ? 303 PRO A O 1 ATOM 2325 C CB . PRO A 1 303 ? -1.134 -29.300 -23.948 1.00 27.84 ? 303 PRO A CB 1 ATOM 2326 C CG . PRO A 1 303 ? -1.140 -30.826 -23.934 1.00 26.38 ? 303 PRO A CG 1 ATOM 2327 C CD . PRO A 1 303 ? 0.277 -31.250 -24.298 1.00 26.90 ? 303 PRO A CD 1 ATOM 2328 N N . ASP A 1 304 ? 0.815 -29.441 -21.163 1.00 27.95 ? 304 ASP A N 1 ATOM 2329 C CA . ASP A 1 304 ? 0.969 -29.050 -19.779 1.00 28.87 ? 304 ASP A CA 1 ATOM 2330 C C . ASP A 1 304 ? 2.072 -27.975 -19.639 1.00 28.78 ? 304 ASP A C 1 ATOM 2331 O O . ASP A 1 304 ? 2.032 -27.109 -18.740 1.00 27.95 ? 304 ASP A O 1 ATOM 2332 C CB . ASP A 1 304 ? 1.321 -30.267 -18.905 1.00 30.31 ? 304 ASP A CB 1 ATOM 2333 C CG . ASP A 1 304 ? 2.437 -31.125 -19.508 1.00 35.45 ? 304 ASP A CG 1 ATOM 2334 O OD1 . ASP A 1 304 ? 2.339 -31.421 -20.734 1.00 40.47 ? 304 ASP A OD1 1 ATOM 2335 O OD2 . ASP A 1 304 ? 3.391 -31.535 -18.763 1.00 37.81 ? 304 ASP A OD2 1 ATOM 2336 N N . ILE A 1 305 ? 3.077 -28.063 -20.495 1.00 27.38 ? 305 ILE A N 1 ATOM 2337 C CA . ILE A 1 305 ? 4.183 -27.092 -20.440 1.00 26.66 ? 305 ILE A CA 1 ATOM 2338 C C . ILE A 1 305 ? 3.715 -25.737 -20.952 1.00 26.25 ? 305 ILE A C 1 ATOM 2339 O O . ILE A 1 305 ? 3.963 -24.732 -20.287 1.00 25.57 ? 305 ILE A O 1 ATOM 2340 C CB . ILE A 1 305 ? 5.436 -27.524 -21.247 1.00 26.26 ? 305 ILE A CB 1 ATOM 2341 C CG1 . ILE A 1 305 ? 5.950 -28.859 -20.722 1.00 26.56 ? 305 ILE A CG1 1 ATOM 2342 C CG2 . ILE A 1 305 ? 6.513 -26.405 -21.197 1.00 24.39 ? 305 ILE A CG2 1 ATOM 2343 C CD1 . ILE A 1 305 ? 7.081 -29.460 -21.539 1.00 31.09 ? 305 ILE A CD1 1 ATOM 2344 N N . LEU A 1 306 ? 3.033 -25.723 -22.113 1.00 24.64 ? 306 LEU A N 1 ATOM 2345 C CA . LEU A 1 306 ? 2.397 -24.511 -22.635 1.00 24.94 ? 306 LEU A CA 1 ATOM 2346 C C . LEU A 1 306 ? 1.504 -23.795 -21.584 1.00 25.42 ? 306 LEU A C 1 ATOM 2347 O O . LEU A 1 306 ? 1.565 -22.580 -21.397 1.00 26.42 ? 306 LEU A O 1 ATOM 2348 C CB . LEU A 1 306 ? 1.597 -24.838 -23.910 1.00 22.93 ? 306 LEU A CB 1 ATOM 2349 C CG . LEU A 1 306 ? 2.446 -25.487 -25.023 1.00 24.33 ? 306 LEU A CG 1 ATOM 2350 C CD1 . LEU A 1 306 ? 1.603 -25.788 -26.245 1.00 20.91 ? 306 LEU A CD1 1 ATOM 2351 C CD2 . LEU A 1 306 ? 3.611 -24.606 -25.477 1.00 22.17 ? 306 LEU A CD2 1 ATOM 2352 N N . LEU A 1 307 ? 0.670 -24.546 -20.883 1.00 26.16 ? 307 LEU A N 1 ATOM 2353 C CA . LEU A 1 307 ? -0.233 -23.932 -19.889 1.00 26.01 ? 307 LEU A CA 1 ATOM 2354 C C . LEU A 1 307 ? 0.601 -23.319 -18.713 1.00 25.72 ? 307 LEU A C 1 ATOM 2355 O O . LEU A 1 307 ? 0.437 -22.158 -18.325 1.00 25.75 ? 307 LEU A O 1 ATOM 2356 C CB . LEU A 1 307 ? -1.198 -25.001 -19.348 1.00 25.35 ? 307 LEU A CB 1 ATOM 2357 C CG . LEU A 1 307 ? -2.241 -24.530 -18.301 1.00 26.35 ? 307 LEU A CG 1 ATOM 2358 C CD1 . LEU A 1 307 ? -3.146 -23.429 -18.860 1.00 26.20 ? 307 LEU A CD1 1 ATOM 2359 C CD2 . LEU A 1 307 ? -3.068 -25.698 -17.847 1.00 25.40 ? 307 LEU A CD2 1 ATOM 2360 N N . GLU A 1 308 ? 1.501 -24.117 -18.168 1.00 26.69 ? 308 GLU A N 1 ATOM 2361 C CA . GLU A 1 308 ? 2.302 -23.690 -17.004 1.00 27.42 ? 308 GLU A CA 1 ATOM 2362 C C . GLU A 1 308 ? 3.029 -22.420 -17.345 1.00 26.44 ? 308 GLU A C 1 ATOM 2363 O O . GLU A 1 308 ? 3.110 -21.534 -16.540 1.00 28.09 ? 308 GLU A O 1 ATOM 2364 C CB . GLU A 1 308 ? 3.260 -24.808 -16.569 1.00 26.70 ? 308 GLU A CB 1 ATOM 2365 C CG . GLU A 1 308 ? 4.203 -24.406 -15.473 1.00 30.48 ? 308 GLU A CG 1 ATOM 2366 C CD . GLU A 1 308 ? 3.534 -24.168 -14.116 1.00 37.63 ? 308 GLU A CD 1 ATOM 2367 O OE1 . GLU A 1 308 ? 4.075 -23.384 -13.296 1.00 39.91 ? 308 GLU A OE1 1 ATOM 2368 O OE2 . GLU A 1 308 ? 2.477 -24.763 -13.833 1.00 38.45 ? 308 GLU A OE2 1 ATOM 2369 N N . LEU A 1 309 ? 3.485 -22.280 -18.582 1.00 25.54 ? 309 LEU A N 1 ATOM 2370 C CA . LEU A 1 309 ? 4.433 -21.210 -18.919 1.00 24.35 ? 309 LEU A CA 1 ATOM 2371 C C . LEU A 1 309 ? 3.752 -20.155 -19.707 1.00 24.70 ? 309 LEU A C 1 ATOM 2372 O O . LEU A 1 309 ? 4.400 -19.318 -20.341 1.00 24.93 ? 309 LEU A O 1 ATOM 2373 C CB . LEU A 1 309 ? 5.642 -21.750 -19.680 1.00 22.96 ? 309 LEU A CB 1 ATOM 2374 C CG . LEU A 1 309 ? 6.484 -22.700 -18.820 1.00 22.19 ? 309 LEU A CG 1 ATOM 2375 C CD1 . LEU A 1 309 ? 7.696 -23.168 -19.602 1.00 20.68 ? 309 LEU A CD1 1 ATOM 2376 C CD2 . LEU A 1 309 ? 6.972 -22.059 -17.476 1.00 20.20 ? 309 LEU A CD2 1 ATOM 2377 N N . GLY A 1 310 ? 2.429 -20.213 -19.697 1.00 25.55 ? 310 GLY A N 1 ATOM 2378 C CA . GLY A 1 310 ? 1.608 -19.097 -20.154 1.00 24.93 ? 310 GLY A CA 1 ATOM 2379 C C . GLY A 1 310 ? 1.580 -18.915 -21.655 1.00 25.95 ? 310 GLY A C 1 ATOM 2380 O O . GLY A 1 310 ? 1.327 -17.792 -22.118 1.00 24.57 ? 310 GLY A O 1 ATOM 2381 N N . GLN A 1 311 ? 1.795 -19.991 -22.432 1.00 26.47 ? 311 GLN A N 1 ATOM 2382 C CA . GLN A 1 311 ? 1.768 -19.852 -23.901 1.00 27.58 ? 311 GLN A CA 1 ATOM 2383 C C . GLN A 1 311 ? 0.419 -20.272 -24.453 1.00 27.83 ? 311 GLN A C 1 ATOM 2384 O O . GLN A 1 311 ? 0.230 -21.437 -24.839 1.00 28.52 ? 311 GLN A O 1 ATOM 2385 C CB . GLN A 1 311 ? 2.804 -20.736 -24.577 1.00 28.84 ? 311 GLN A CB 1 ATOM 2386 C CG . GLN A 1 311 ? 4.173 -20.624 -24.043 1.00 33.53 ? 311 GLN A CG 1 ATOM 2387 C CD . GLN A 1 311 ? 4.708 -19.229 -24.274 1.00 40.79 ? 311 GLN A CD 1 ATOM 2388 O OE1 . GLN A 1 311 ? 4.694 -18.701 -25.426 1.00 40.24 ? 311 GLN A OE1 1 ATOM 2389 N NE2 . GLN A 1 311 ? 5.155 -18.592 -23.172 1.00 39.45 ? 311 GLN A NE2 1 ATOM 2390 N N . PHE A 1 312 ? -0.516 -19.336 -24.517 1.00 26.87 ? 312 PHE A N 1 ATOM 2391 C CA . PHE A 1 312 ? -1.843 -19.630 -24.982 1.00 26.26 ? 312 PHE A CA 1 ATOM 2392 C C . PHE A 1 312 ? -2.552 -18.312 -25.287 1.00 26.92 ? 312 PHE A C 1 ATOM 2393 O O . PHE A 1 312 ? -2.095 -17.231 -24.865 1.00 27.08 ? 312 PHE A O 1 ATOM 2394 C CB . PHE A 1 312 ? -2.615 -20.451 -23.930 1.00 26.51 ? 312 PHE A CB 1 ATOM 2395 C CG . PHE A 1 312 ? -2.553 -19.886 -22.514 1.00 26.92 ? 312 PHE A CG 1 ATOM 2396 C CD1 . PHE A 1 312 ? -3.377 -18.870 -22.124 1.00 26.78 ? 312 PHE A CD1 1 ATOM 2397 C CD2 . PHE A 1 312 ? -1.669 -20.404 -21.579 1.00 28.91 ? 312 PHE A CD2 1 ATOM 2398 C CE1 . PHE A 1 312 ? -3.324 -18.350 -20.843 1.00 26.34 ? 312 PHE A CE1 1 ATOM 2399 C CE2 . PHE A 1 312 ? -1.617 -19.916 -20.272 1.00 25.26 ? 312 PHE A CE2 1 ATOM 2400 C CZ . PHE A 1 312 ? -2.456 -18.875 -19.902 1.00 24.53 ? 312 PHE A CZ 1 ATOM 2401 N N . LYS A 1 313 ? -3.638 -18.387 -26.029 1.00 25.43 ? 313 LYS A N 1 ATOM 2402 C CA . LYS A 1 313 ? -4.412 -17.223 -26.355 1.00 24.64 ? 313 LYS A CA 1 ATOM 2403 C C . LYS A 1 313 ? -4.908 -16.499 -25.090 1.00 25.59 ? 313 LYS A C 1 ATOM 2404 O O . LYS A 1 313 ? -5.532 -17.105 -24.199 1.00 25.16 ? 313 LYS A O 1 ATOM 2405 C CB . LYS A 1 313 ? -5.620 -17.636 -27.212 1.00 24.99 ? 313 LYS A CB 1 ATOM 2406 C CG . LYS A 1 313 ? -6.513 -16.466 -27.648 1.00 23.67 ? 313 LYS A CG 1 ATOM 2407 C CD . LYS A 1 313 ? -7.702 -16.980 -28.461 1.00 26.16 ? 313 LYS A CD 1 ATOM 2408 C CE . LYS A 1 313 ? -8.618 -15.841 -28.872 1.00 23.32 ? 313 LYS A CE 1 ATOM 2409 N NZ . LYS A 1 313 ? -7.936 -15.031 -29.944 1.00 24.18 ? 313 LYS A NZ 1 ATOM 2410 N N . LYS A 1 314 ? -4.624 -15.200 -25.018 1.00 24.38 ? 314 LYS A N 1 ATOM 2411 C CA . LYS A 1 314 ? -4.935 -14.384 -23.850 1.00 25.43 ? 314 LYS A CA 1 ATOM 2412 C C . LYS A 1 314 ? -6.347 -13.812 -24.037 1.00 25.21 ? 314 LYS A C 1 ATOM 2413 O O . LYS A 1 314 ? -6.542 -12.939 -24.887 1.00 25.19 ? 314 LYS A O 1 ATOM 2414 C CB . LYS A 1 314 ? -3.886 -13.233 -23.723 1.00 24.70 ? 314 LYS A CB 1 ATOM 2415 C CG . LYS A 1 314 ? -2.488 -13.771 -23.321 1.00 25.27 ? 314 LYS A CG 1 ATOM 2416 C CD . LYS A 1 314 ? -2.543 -14.401 -21.933 1.00 27.97 ? 314 LYS A CD 1 ATOM 2417 C CE . LYS A 1 314 ? -1.553 -15.506 -21.677 1.00 28.76 ? 314 LYS A CE 1 ATOM 2418 N NZ . LYS A 1 314 ? -0.451 -15.539 -22.667 1.00 26.96 ? 314 LYS A NZ 1 ATOM 2419 N N . THR A 1 315 ? -7.339 -14.360 -23.325 1.00 23.46 ? 315 THR A N 1 ATOM 2420 C CA . THR A 1 315 ? -8.733 -13.973 -23.506 1.00 22.54 ? 315 THR A CA 1 ATOM 2421 C C . THR A 1 315 ? -9.534 -14.462 -22.283 1.00 22.82 ? 315 THR A C 1 ATOM 2422 O O . THR A 1 315 ? -8.954 -15.028 -21.357 1.00 22.21 ? 315 THR A O 1 ATOM 2423 C CB . THR A 1 315 ? -9.331 -14.521 -24.859 1.00 22.81 ? 315 THR A CB 1 ATOM 2424 O OG1 . THR A 1 315 ? -10.627 -13.979 -25.044 1.00 19.83 ? 315 THR A OG1 1 ATOM 2425 C CG2 . THR A 1 315 ? -9.497 -16.053 -24.822 1.00 21.92 ? 315 THR A CG2 1 ATOM 2426 N N . GLN A 1 316 ? -10.837 -14.228 -22.246 1.00 22.77 ? 316 GLN A N 1 ATOM 2427 C CA . GLN A 1 316 ? -11.637 -14.647 -21.074 1.00 22.99 ? 316 GLN A CA 1 ATOM 2428 C C . GLN A 1 316 ? -12.054 -16.090 -21.290 1.00 23.25 ? 316 GLN A C 1 ATOM 2429 O O . GLN A 1 316 ? -12.253 -16.511 -22.440 1.00 21.69 ? 316 GLN A O 1 ATOM 2430 C CB . GLN A 1 316 ? -12.896 -13.804 -20.910 1.00 21.85 ? 316 GLN A CB 1 ATOM 2431 C CG . GLN A 1 316 ? -12.654 -12.320 -20.718 1.00 24.22 ? 316 GLN A CG 1 ATOM 2432 C CD . GLN A 1 316 ? -12.197 -11.665 -22.030 1.00 25.64 ? 316 GLN A CD 1 ATOM 2433 O OE1 . GLN A 1 316 ? -12.799 -11.851 -23.093 1.00 22.29 ? 316 GLN A OE1 1 ATOM 2434 N NE2 . GLN A 1 316 ? -11.097 -10.936 -21.959 1.00 27.55 ? 316 GLN A NE2 1 ATOM 2435 N N . ILE A 1 317 ? -12.191 -16.849 -20.212 1.00 21.85 ? 317 ILE A N 1 ATOM 2436 C CA . ILE A 1 317 ? -12.739 -18.217 -20.337 1.00 20.19 ? 317 ILE A CA 1 ATOM 2437 C C . ILE A 1 317 ? -13.867 -18.397 -19.311 1.00 20.07 ? 317 ILE A C 1 ATOM 2438 O O . ILE A 1 317 ? -13.857 -17.737 -18.258 1.00 18.37 ? 317 ILE A O 1 ATOM 2439 C CB . ILE A 1 317 ? -11.695 -19.307 -20.080 1.00 20.32 ? 317 ILE A CB 1 ATOM 2440 C CG1 . ILE A 1 317 ? -11.037 -19.092 -18.729 1.00 20.20 ? 317 ILE A CG1 1 ATOM 2441 C CG2 . ILE A 1 317 ? -10.649 -19.320 -21.170 1.00 21.53 ? 317 ILE A CG2 1 ATOM 2442 C CD1 . ILE A 1 317 ? -10.042 -20.225 -18.260 1.00 19.07 ? 317 ILE A CD1 1 ATOM 2443 N N . LEU A 1 318 ? -14.825 -19.272 -19.628 1.00 17.03 ? 318 LEU A N 1 ATOM 2444 C CA . LEU A 1 318 ? -15.903 -19.639 -18.760 1.00 17.18 ? 318 LEU A CA 1 ATOM 2445 C C . LEU A 1 318 ? -15.784 -21.147 -18.621 1.00 18.13 ? 318 LEU A C 1 ATOM 2446 O O . LEU A 1 318 ? -15.751 -21.889 -19.641 1.00 18.89 ? 318 LEU A O 1 ATOM 2447 C CB . LEU A 1 318 ? -17.242 -19.236 -19.394 1.00 16.42 ? 318 LEU A CB 1 ATOM 2448 C CG . LEU A 1 318 ? -18.532 -19.257 -18.534 1.00 17.85 ? 318 LEU A CG 1 ATOM 2449 C CD1 . LEU A 1 318 ? -19.729 -18.664 -19.334 1.00 17.54 ? 318 LEU A CD1 1 ATOM 2450 C CD2 . LEU A 1 318 ? -18.916 -20.628 -18.205 1.00 22.31 ? 318 LEU A CD2 1 ATOM 2451 N N . VAL A 1 319 ? -15.663 -21.637 -17.396 1.00 17.44 ? 319 VAL A N 1 ATOM 2452 C CA . VAL A 1 319 ? -15.347 -23.047 -17.201 1.00 16.81 ? 319 VAL A CA 1 ATOM 2453 C C . VAL A 1 319 ? -16.286 -23.581 -16.152 1.00 17.70 ? 319 VAL A C 1 ATOM 2454 O O . VAL A 1 319 ? -16.655 -22.839 -15.193 1.00 17.85 ? 319 VAL A O 1 ATOM 2455 C CB . VAL A 1 319 ? -13.877 -23.227 -16.739 1.00 17.33 ? 319 VAL A CB 1 ATOM 2456 C CG1 . VAL A 1 319 ? -13.506 -24.713 -16.752 1.00 16.92 ? 319 VAL A CG1 1 ATOM 2457 C CG2 . VAL A 1 319 ? -12.899 -22.481 -17.709 1.00 15.30 ? 319 VAL A CG2 1 ATOM 2458 N N . GLY A 1 320 ? -16.703 -24.835 -16.283 1.00 17.04 ? 320 GLY A N 1 ATOM 2459 C CA . GLY A 1 320 ? -17.623 -25.366 -15.255 1.00 18.55 ? 320 GLY A CA 1 ATOM 2460 C C . GLY A 1 320 ? -17.646 -26.882 -15.206 1.00 19.83 ? 320 GLY A C 1 ATOM 2461 O O . GLY A 1 320 ? -17.057 -27.533 -16.072 1.00 20.45 ? 320 GLY A O 1 ATOM 2462 N N . VAL A 1 321 ? -18.350 -27.441 -14.212 1.00 20.10 ? 321 VAL A N 1 ATOM 2463 C CA . VAL A 1 321 ? -18.496 -28.861 -14.049 1.00 18.81 ? 321 VAL A CA 1 ATOM 2464 C C . VAL A 1 321 ? -19.833 -29.124 -13.360 1.00 20.04 ? 321 VAL A C 1 ATOM 2465 O O . VAL A 1 321 ? -20.489 -28.212 -12.843 1.00 18.69 ? 321 VAL A O 1 ATOM 2466 C CB . VAL A 1 321 ? -17.314 -29.524 -13.239 1.00 19.38 ? 321 VAL A CB 1 ATOM 2467 C CG1 . VAL A 1 321 ? -16.024 -29.506 -14.057 1.00 15.78 ? 321 VAL A CG1 1 ATOM 2468 C CG2 . VAL A 1 321 ? -17.165 -28.816 -11.846 1.00 20.27 ? 321 VAL A CG2 1 ATOM 2469 N N . ASN A 1 322 ? -20.263 -30.393 -13.425 1.00 20.97 ? 322 ASN A N 1 ATOM 2470 C CA . ASN A 1 322 ? -21.496 -30.817 -12.831 1.00 21.24 ? 322 ASN A CA 1 ATOM 2471 C C . ASN A 1 322 ? -21.204 -31.520 -11.564 1.00 22.20 ? 322 ASN A C 1 ATOM 2472 O O . ASN A 1 322 ? -20.135 -32.103 -11.407 1.00 21.75 ? 322 ASN A O 1 ATOM 2473 C CB . ASN A 1 322 ? -22.236 -31.763 -13.796 1.00 22.04 ? 322 ASN A CB 1 ATOM 2474 C CG . ASN A 1 322 ? -22.614 -31.071 -15.069 1.00 23.27 ? 322 ASN A CG 1 ATOM 2475 O OD1 . ASN A 1 322 ? -22.363 -29.854 -15.190 1.00 22.41 ? 322 ASN A OD1 1 ATOM 2476 N ND2 . ASN A 1 322 ? -23.150 -31.818 -16.047 1.00 18.41 ? 322 ASN A ND2 1 ATOM 2477 N N . LYS A 1 323 ? -22.179 -31.513 -10.666 1.00 22.90 ? 323 LYS A N 1 ATOM 2478 C CA . LYS A 1 323 ? -22.004 -32.096 -9.332 1.00 22.21 ? 323 LYS A CA 1 ATOM 2479 C C . LYS A 1 323 ? -21.665 -33.563 -9.298 1.00 22.37 ? 323 LYS A C 1 ATOM 2480 O O . LYS A 1 323 ? -20.804 -33.997 -8.523 1.00 21.61 ? 323 LYS A O 1 ATOM 2481 C CB . LYS A 1 323 ? -23.270 -31.838 -8.518 1.00 22.98 ? 323 LYS A CB 1 ATOM 2482 C CG . LYS A 1 323 ? -23.314 -32.533 -7.194 1.00 23.76 ? 323 LYS A CG 1 ATOM 2483 C CD . LYS A 1 323 ? -24.606 -32.121 -6.496 1.00 32.98 ? 323 LYS A CD 1 ATOM 2484 C CE . LYS A 1 323 ? -24.768 -32.832 -5.149 1.00 39.12 ? 323 LYS A CE 1 ATOM 2485 N NZ . LYS A 1 323 ? -25.918 -32.189 -4.418 1.00 45.98 ? 323 LYS A NZ 1 ATOM 2486 N N . ASP A 1 324 ? -22.294 -34.359 -10.147 1.00 22.82 ? 324 ASP A N 1 ATOM 2487 C CA . ASP A 1 324 ? -21.953 -35.775 -10.205 1.00 23.62 ? 324 ASP A CA 1 ATOM 2488 C C . ASP A 1 324 ? -21.320 -36.265 -11.519 1.00 23.90 ? 324 ASP A C 1 ATOM 2489 O O . ASP A 1 324 ? -21.745 -37.267 -12.077 1.00 24.88 ? 324 ASP A O 1 ATOM 2490 C CB . ASP A 1 324 ? -23.184 -36.629 -9.898 1.00 23.10 ? 324 ASP A CB 1 ATOM 2491 C CG . ASP A 1 324 ? -23.760 -36.327 -8.530 1.00 24.17 ? 324 ASP A CG 1 ATOM 2492 O OD1 . ASP A 1 324 ? -23.127 -36.721 -7.569 1.00 22.24 ? 324 ASP A OD1 1 ATOM 2493 O OD2 . ASP A 1 324 ? -24.834 -35.712 -8.412 1.00 21.10 ? 324 ASP A OD2 1 ATOM 2494 N N . GLU A 1 325 ? -20.253 -35.639 -11.964 1.00 24.56 ? 325 GLU A N 1 ATOM 2495 C CA . GLU A 1 325 ? -19.580 -36.069 -13.187 1.00 24.44 ? 325 GLU A CA 1 ATOM 2496 C C . GLU A 1 325 ? -19.320 -37.593 -13.332 1.00 25.11 ? 325 GLU A C 1 ATOM 2497 O O . GLU A 1 325 ? -19.474 -38.184 -14.428 1.00 26.76 ? 325 GLU A O 1 ATOM 2498 C CB . GLU A 1 325 ? -18.249 -35.325 -13.339 1.00 23.41 ? 325 GLU A CB 1 ATOM 2499 C CG . GLU A 1 325 ? -18.403 -33.806 -13.529 1.00 22.62 ? 325 GLU A CG 1 ATOM 2500 C CD . GLU A 1 325 ? -18.724 -33.429 -14.968 1.00 22.28 ? 325 GLU A CD 1 ATOM 2501 O OE1 . GLU A 1 325 ? -18.942 -34.349 -15.808 1.00 19.42 ? 325 GLU A OE1 1 ATOM 2502 O OE2 . GLU A 1 325 ? -18.836 -32.220 -15.237 1.00 18.78 ? 325 GLU A OE2 1 ATOM 2503 N N . GLY A 1 326 ? -18.851 -38.227 -12.277 1.00 25.21 ? 326 GLY A N 1 ATOM 2504 C CA . GLY A 1 326 ? -18.345 -39.575 -12.448 1.00 25.26 ? 326 GLY A CA 1 ATOM 2505 C C . GLY A 1 326 ? -19.357 -40.705 -12.468 1.00 25.93 ? 326 GLY A C 1 ATOM 2506 O O . GLY A 1 326 ? -18.993 -41.822 -12.845 1.00 28.17 ? 326 GLY A O 1 ATOM 2507 N N . THR A 1 327 ? -20.618 -40.448 -12.100 1.00 25.79 ? 327 THR A N 1 ATOM 2508 C CA . THR A 1 327 ? -21.616 -41.520 -11.956 1.00 26.75 ? 327 THR A CA 1 ATOM 2509 C C . THR A 1 327 ? -21.991 -42.266 -13.250 1.00 28.02 ? 327 THR A C 1 ATOM 2510 O O . THR A 1 327 ? -22.124 -43.490 -13.241 1.00 28.85 ? 327 THR A O 1 ATOM 2511 C CB . THR A 1 327 ? -22.896 -41.052 -11.280 1.00 26.24 ? 327 THR A CB 1 ATOM 2512 O OG1 . THR A 1 327 ? -23.493 -39.973 -12.021 1.00 24.44 ? 327 THR A OG1 1 ATOM 2513 C CG2 . THR A 1 327 ? -22.656 -40.629 -9.783 1.00 26.50 ? 327 THR A CG2 1 ATOM 2514 N N . ALA A 1 328 ? -22.187 -41.516 -14.333 1.00 29.42 ? 328 ALA A N 1 ATOM 2515 C CA . ALA A 1 328 ? -22.531 -42.039 -15.654 1.00 29.21 ? 328 ALA A CA 1 ATOM 2516 C C . ALA A 1 328 ? -21.610 -43.204 -16.013 1.00 30.13 ? 328 ALA A C 1 ATOM 2517 O O . ALA A 1 328 ? -22.038 -44.168 -16.649 1.00 31.80 ? 328 ALA A O 1 ATOM 2518 C CB . ALA A 1 328 ? -22.399 -40.912 -16.708 1.00 27.91 ? 328 ALA A CB 1 ATOM 2519 N N . PHE A 1 329 ? -20.345 -43.170 -15.588 1.00 29.72 ? 329 PHE A N 1 ATOM 2520 C CA . PHE A 1 329 ? -19.409 -44.148 -16.124 1.00 29.34 ? 329 PHE A CA 1 ATOM 2521 C C . PHE A 1 329 ? -19.415 -45.464 -15.373 1.00 29.35 ? 329 PHE A C 1 ATOM 2522 O O . PHE A 1 329 ? -18.864 -46.472 -15.827 1.00 28.30 ? 329 PHE A O 1 ATOM 2523 C CB . PHE A 1 329 ? -17.991 -43.543 -16.236 1.00 29.27 ? 329 PHE A CB 1 ATOM 2524 C CG . PHE A 1 329 ? -17.991 -42.281 -17.031 1.00 29.35 ? 329 PHE A CG 1 ATOM 2525 C CD1 . PHE A 1 329 ? -18.180 -41.048 -16.406 1.00 26.20 ? 329 PHE A CD1 1 ATOM 2526 C CD2 . PHE A 1 329 ? -17.883 -42.324 -18.414 1.00 30.18 ? 329 PHE A CD2 1 ATOM 2527 C CE1 . PHE A 1 329 ? -18.248 -39.864 -17.140 1.00 23.06 ? 329 PHE A CE1 1 ATOM 2528 C CE2 . PHE A 1 329 ? -17.933 -41.145 -19.157 1.00 30.26 ? 329 PHE A CE2 1 ATOM 2529 C CZ . PHE A 1 329 ? -18.128 -39.922 -18.531 1.00 28.22 ? 329 PHE A CZ 1 ATOM 2530 N N . LEU A 1 330 ? -20.008 -45.434 -14.195 1.00 29.73 ? 330 LEU A N 1 ATOM 2531 C CA . LEU A 1 330 ? -19.831 -46.561 -13.286 1.00 30.65 ? 330 LEU A CA 1 ATOM 2532 C C . LEU A 1 330 ? -20.658 -47.747 -13.786 1.00 30.96 ? 330 LEU A C 1 ATOM 2533 O O . LEU A 1 330 ? -20.328 -48.873 -13.486 1.00 29.71 ? 330 LEU A O 1 ATOM 2534 C CB . LEU A 1 330 ? -20.266 -46.176 -11.863 1.00 30.34 ? 330 LEU A CB 1 ATOM 2535 C CG . LEU A 1 330 ? -19.530 -44.985 -11.222 1.00 28.72 ? 330 LEU A CG 1 ATOM 2536 C CD1 . LEU A 1 330 ? -20.073 -44.770 -9.820 1.00 25.58 ? 330 LEU A CD1 1 ATOM 2537 C CD2 . LEU A 1 330 ? -18.077 -45.259 -11.218 1.00 27.48 ? 330 LEU A CD2 1 ATOM 2538 N N . VAL A 1 331 ? -21.744 -47.474 -14.516 1.00 31.41 ? 331 VAL A N 1 ATOM 2539 C CA . VAL A 1 331 ? -22.588 -48.568 -15.045 1.00 32.16 ? 331 VAL A CA 1 ATOM 2540 C C . VAL A 1 331 ? -22.042 -49.200 -16.313 1.00 33.21 ? 331 VAL A C 1 ATOM 2541 O O . VAL A 1 331 ? -22.654 -50.121 -16.861 1.00 33.71 ? 331 VAL A O 1 ATOM 2542 C CB . VAL A 1 331 ? -24.053 -48.153 -15.259 1.00 32.23 ? 331 VAL A CB 1 ATOM 2543 C CG1 . VAL A 1 331 ? -24.673 -47.747 -13.906 1.00 31.61 ? 331 VAL A CG1 1 ATOM 2544 C CG2 . VAL A 1 331 ? -24.177 -47.030 -16.349 1.00 30.16 ? 331 VAL A CG2 1 ATOM 2545 N N . TYR A 1 332 ? -20.885 -48.733 -16.788 1.00 33.26 ? 332 TYR A N 1 ATOM 2546 C CA . TYR A 1 332 ? -20.254 -49.367 -17.941 1.00 32.00 ? 332 TYR A CA 1 ATOM 2547 C C . TYR A 1 332 ? -19.082 -50.241 -17.501 1.00 33.36 ? 332 TYR A C 1 ATOM 2548 O O . TYR A 1 332 ? -18.079 -50.361 -18.212 1.00 33.45 ? 332 TYR A O 1 ATOM 2549 C CB . TYR A 1 332 ? -19.784 -48.324 -18.946 1.00 30.84 ? 332 TYR A CB 1 ATOM 2550 C CG . TYR A 1 332 ? -20.925 -47.604 -19.621 1.00 31.70 ? 332 TYR A CG 1 ATOM 2551 C CD1 . TYR A 1 332 ? -21.583 -46.554 -19.001 1.00 29.18 ? 332 TYR A CD1 1 ATOM 2552 C CD2 . TYR A 1 332 ? -21.348 -47.986 -20.891 1.00 29.63 ? 332 TYR A CD2 1 ATOM 2553 C CE1 . TYR A 1 332 ? -22.635 -45.902 -19.633 1.00 27.52 ? 332 TYR A CE1 1 ATOM 2554 C CE2 . TYR A 1 332 ? -22.359 -47.342 -21.525 1.00 30.37 ? 332 TYR A CE2 1 ATOM 2555 C CZ . TYR A 1 332 ? -23.007 -46.309 -20.901 1.00 30.03 ? 332 TYR A CZ 1 ATOM 2556 O OH . TYR A 1 332 ? -24.027 -45.704 -21.573 1.00 27.50 ? 332 TYR A OH 1 ATOM 2557 N N . GLY A 1 333 ? -19.188 -50.855 -16.329 1.00 34.79 ? 333 GLY A N 1 ATOM 2558 C CA . GLY A 1 333 ? -18.227 -51.877 -16.012 1.00 36.75 ? 333 GLY A CA 1 ATOM 2559 C C . GLY A 1 333 ? -17.818 -51.996 -14.558 1.00 38.34 ? 333 GLY A C 1 ATOM 2560 O O . GLY A 1 333 ? -17.061 -52.901 -14.224 1.00 39.29 ? 333 GLY A O 1 ATOM 2561 N N . ALA A 1 334 ? -18.261 -51.096 -13.688 1.00 37.77 ? 334 ALA A N 1 ATOM 2562 C CA . ALA A 1 334 ? -17.888 -51.245 -12.288 1.00 38.42 ? 334 ALA A CA 1 ATOM 2563 C C . ALA A 1 334 ? -18.801 -52.302 -11.676 1.00 38.89 ? 334 ALA A C 1 ATOM 2564 O O . ALA A 1 334 ? -19.999 -52.313 -11.957 1.00 39.53 ? 334 ALA A O 1 ATOM 2565 C CB . ALA A 1 334 ? -17.992 -49.897 -11.521 1.00 37.43 ? 334 ALA A CB 1 ATOM 2566 N N . PRO A 1 335 ? -18.239 -53.197 -10.836 1.00 39.37 ? 335 PRO A N 1 ATOM 2567 C CA . PRO A 1 335 ? -18.978 -54.341 -10.308 1.00 38.52 ? 335 PRO A CA 1 ATOM 2568 C C . PRO A 1 335 ? -19.977 -53.922 -9.239 1.00 37.93 ? 335 PRO A C 1 ATOM 2569 O O . PRO A 1 335 ? -19.668 -53.102 -8.398 1.00 37.74 ? 335 PRO A O 1 ATOM 2570 C CB . PRO A 1 335 ? -17.872 -55.205 -9.698 1.00 39.35 ? 335 PRO A CB 1 ATOM 2571 C CG . PRO A 1 335 ? -16.626 -54.821 -10.471 1.00 39.81 ? 335 PRO A CG 1 ATOM 2572 C CD . PRO A 1 335 ? -16.785 -53.341 -10.631 1.00 39.78 ? 335 PRO A CD 1 ATOM 2573 N N . GLY A 1 336 ? -21.190 -54.460 -9.294 1.00 37.36 ? 336 GLY A N 1 ATOM 2574 C CA . GLY A 1 336 ? -22.248 -54.070 -8.360 1.00 35.41 ? 336 GLY A CA 1 ATOM 2575 C C . GLY A 1 336 ? -23.083 -52.872 -8.749 1.00 34.50 ? 336 GLY A C 1 ATOM 2576 O O . GLY A 1 336 ? -24.042 -52.517 -8.036 1.00 34.02 ? 336 GLY A O 1 ATOM 2577 N N . PHE A 1 337 ? -22.730 -52.232 -9.867 1.00 33.33 ? 337 PHE A N 1 ATOM 2578 C CA . PHE A 1 337 ? -23.408 -50.998 -10.285 1.00 33.18 ? 337 PHE A CA 1 ATOM 2579 C C . PHE A 1 337 ? -24.491 -51.287 -11.321 1.00 34.09 ? 337 PHE A C 1 ATOM 2580 O O . PHE A 1 337 ? -24.232 -52.024 -12.269 1.00 34.96 ? 337 PHE A O 1 ATOM 2581 C CB . PHE A 1 337 ? -22.401 -49.965 -10.841 1.00 31.50 ? 337 PHE A CB 1 ATOM 2582 C CG . PHE A 1 337 ? -21.691 -49.190 -9.743 1.00 29.38 ? 337 PHE A CG 1 ATOM 2583 C CD1 . PHE A 1 337 ? -20.507 -49.640 -9.228 1.00 25.62 ? 337 PHE A CD1 1 ATOM 2584 C CD2 . PHE A 1 337 ? -22.275 -48.076 -9.183 1.00 28.00 ? 337 PHE A CD2 1 ATOM 2585 C CE1 . PHE A 1 337 ? -19.895 -48.952 -8.191 1.00 30.43 ? 337 PHE A CE1 1 ATOM 2586 C CE2 . PHE A 1 337 ? -21.672 -47.395 -8.157 1.00 30.98 ? 337 PHE A CE2 1 ATOM 2587 C CZ . PHE A 1 337 ? -20.481 -47.825 -7.668 1.00 26.25 ? 337 PHE A CZ 1 ATOM 2588 N N . SER A 1 338 ? -25.674 -50.701 -11.159 1.00 34.05 ? 338 SER A N 1 ATOM 2589 C CA . SER A 1 338 ? -26.698 -50.836 -12.207 1.00 34.27 ? 338 SER A CA 1 ATOM 2590 C C . SER A 1 338 ? -27.570 -49.631 -12.299 1.00 33.26 ? 338 SER A C 1 ATOM 2591 O O . SER A 1 338 ? -27.975 -49.111 -11.271 1.00 32.49 ? 338 SER A O 1 ATOM 2592 C CB . SER A 1 338 ? -27.611 -52.044 -11.916 1.00 35.27 ? 338 SER A CB 1 ATOM 2593 O OG . SER A 1 338 ? -28.767 -52.071 -12.785 1.00 37.79 ? 338 SER A OG 1 ATOM 2594 N N . LYS A 1 339 ? -27.916 -49.203 -13.519 1.00 33.06 ? 339 LYS A N 1 ATOM 2595 C CA . LYS A 1 339 ? -28.908 -48.142 -13.663 1.00 33.02 ? 339 LYS A CA 1 ATOM 2596 C C . LYS A 1 339 ? -30.271 -48.619 -13.122 1.00 34.47 ? 339 LYS A C 1 ATOM 2597 O O . LYS A 1 339 ? -31.135 -47.799 -12.831 1.00 35.26 ? 339 LYS A O 1 ATOM 2598 C CB . LYS A 1 339 ? -29.018 -47.660 -15.117 1.00 32.64 ? 339 LYS A CB 1 ATOM 2599 C CG . LYS A 1 339 ? -29.714 -48.665 -16.062 1.00 31.96 ? 339 LYS A CG 1 ATOM 2600 C CD . LYS A 1 339 ? -30.106 -48.072 -17.421 1.00 31.26 ? 339 LYS A CD 1 ATOM 2601 C CE . LYS A 1 339 ? -31.178 -48.964 -18.131 1.00 28.46 ? 339 LYS A CE 1 ATOM 2602 N NZ . LYS A 1 339 ? -32.554 -48.595 -17.532 1.00 33.00 ? 339 LYS A NZ 1 ATOM 2603 N N . ASP A 1 340 ? -30.437 -49.933 -12.938 1.00 35.68 ? 340 ASP A N 1 ATOM 2604 C CA . ASP A 1 340 ? -31.733 -50.556 -12.579 1.00 37.21 ? 340 ASP A CA 1 ATOM 2605 C C . ASP A 1 340 ? -31.939 -50.956 -11.086 1.00 39.14 ? 340 ASP A C 1 ATOM 2606 O O . ASP A 1 340 ? -32.905 -51.678 -10.746 1.00 38.66 ? 340 ASP A O 1 ATOM 2607 C CB . ASP A 1 340 ? -31.958 -51.790 -13.463 1.00 36.78 ? 340 ASP A CB 1 ATOM 2608 C CG . ASP A 1 340 ? -32.191 -51.415 -14.918 1.00 36.40 ? 340 ASP A CG 1 ATOM 2609 O OD1 . ASP A 1 340 ? -31.520 -51.974 -15.797 1.00 37.31 ? 340 ASP A OD1 1 ATOM 2610 O OD2 . ASP A 1 340 ? -33.020 -50.524 -15.182 1.00 34.19 ? 340 ASP A OD2 1 ATOM 2611 N N . ASN A 1 341 ? -31.034 -50.506 -10.212 1.00 39.36 ? 341 ASN A N 1 ATOM 2612 C CA . ASN A 1 341 ? -31.195 -50.610 -8.753 1.00 40.55 ? 341 ASN A CA 1 ATOM 2613 C C . ASN A 1 341 ? -30.313 -49.551 -8.134 1.00 40.99 ? 341 ASN A C 1 ATOM 2614 O O . ASN A 1 341 ? -29.651 -48.799 -8.850 1.00 40.72 ? 341 ASN A O 1 ATOM 2615 C CB . ASN A 1 341 ? -30.857 -52.003 -8.201 1.00 40.11 ? 341 ASN A CB 1 ATOM 2616 C CG . ASN A 1 341 ? -29.445 -52.406 -8.471 1.00 41.85 ? 341 ASN A CG 1 ATOM 2617 O OD1 . ASN A 1 341 ? -28.518 -51.581 -8.385 1.00 43.46 ? 341 ASN A OD1 1 ATOM 2618 N ND2 . ASN A 1 341 ? -29.269 -53.672 -8.855 1.00 41.41 ? 341 ASN A ND2 1 ATOM 2619 N N . ASN A 1 342 ? -30.316 -49.464 -6.811 1.00 41.81 ? 342 ASN A N 1 ATOM 2620 C CA . ASN A 1 342 ? -29.628 -48.361 -6.153 1.00 41.98 ? 342 ASN A CA 1 ATOM 2621 C C . ASN A 1 342 ? -28.116 -48.575 -5.981 1.00 41.17 ? 342 ASN A C 1 ATOM 2622 O O . ASN A 1 342 ? -27.439 -47.728 -5.459 1.00 42.13 ? 342 ASN A O 1 ATOM 2623 C CB . ASN A 1 342 ? -30.314 -48.000 -4.833 1.00 43.08 ? 342 ASN A CB 1 ATOM 2624 C CG . ASN A 1 342 ? -30.249 -49.129 -3.821 1.00 45.49 ? 342 ASN A CG 1 ATOM 2625 O OD1 . ASN A 1 342 ? -29.611 -50.176 -4.057 1.00 46.55 ? 342 ASN A OD1 1 ATOM 2626 N ND2 . ASN A 1 342 ? -30.912 -48.928 -2.679 1.00 49.93 ? 342 ASN A ND2 1 ATOM 2627 N N . SER A 1 343 ? -27.602 -49.708 -6.419 1.00 40.26 ? 343 SER A N 1 ATOM 2628 C CA . SER A 1 343 ? -26.174 -49.891 -6.587 1.00 39.91 ? 343 SER A CA 1 ATOM 2629 C C . SER A 1 343 ? -25.362 -49.785 -5.287 1.00 40.25 ? 343 SER A C 1 ATOM 2630 O O . SER A 1 343 ? -24.157 -49.463 -5.309 1.00 40.27 ? 343 SER A O 1 ATOM 2631 C CB . SER A 1 343 ? -25.667 -48.913 -7.634 1.00 38.99 ? 343 SER A CB 1 ATOM 2632 O OG . SER A 1 343 ? -26.105 -49.316 -8.925 1.00 38.73 ? 343 SER A OG 1 ATOM 2633 N N . ILE A 1 344 ? -26.006 -50.090 -4.162 1.00 39.28 ? 344 ILE A N 1 ATOM 2634 C CA . ILE A 1 344 ? -25.313 -50.077 -2.876 1.00 38.94 ? 344 ILE A CA 1 ATOM 2635 C C . ILE A 1 344 ? -24.184 -51.079 -2.983 1.00 38.45 ? 344 ILE A C 1 ATOM 2636 O O . ILE A 1 344 ? -24.452 -52.235 -2.978 1.00 40.00 ? 344 ILE A O 1 ATOM 2637 C CB . ILE A 1 344 ? -26.283 -50.512 -1.732 1.00 39.59 ? 344 ILE A CB 1 ATOM 2638 C CG1 . ILE A 1 344 ? -27.327 -49.422 -1.474 1.00 37.88 ? 344 ILE A CG1 1 ATOM 2639 C CG2 . ILE A 1 344 ? -25.523 -50.804 -0.436 1.00 37.87 ? 344 ILE A CG2 1 ATOM 2640 C CD1 . ILE A 1 344 ? -26.719 -48.061 -1.388 1.00 37.36 ? 344 ILE A CD1 1 ATOM 2641 N N . ILE A 1 345 ? -22.935 -50.681 -3.134 1.00 37.79 ? 345 ILE A N 1 ATOM 2642 C CA . ILE A 1 345 ? -21.870 -51.676 -3.285 1.00 36.95 ? 345 ILE A CA 1 ATOM 2643 C C . ILE A 1 345 ? -21.075 -51.834 -1.995 1.00 38.43 ? 345 ILE A C 1 ATOM 2644 O O . ILE A 1 345 ? -21.223 -51.022 -1.053 1.00 37.85 ? 345 ILE A O 1 ATOM 2645 C CB . ILE A 1 345 ? -20.883 -51.268 -4.356 1.00 37.14 ? 345 ILE A CB 1 ATOM 2646 C CG1 . ILE A 1 345 ? -20.392 -49.819 -4.083 1.00 36.38 ? 345 ILE A CG1 1 ATOM 2647 C CG2 . ILE A 1 345 ? -21.504 -51.426 -5.709 1.00 35.71 ? 345 ILE A CG2 1 ATOM 2648 C CD1 . ILE A 1 345 ? -19.031 -49.508 -4.687 1.00 35.13 ? 345 ILE A CD1 1 ATOM 2649 N N . THR A 1 346 ? -20.229 -52.871 -1.934 1.00 38.81 ? 346 THR A N 1 ATOM 2650 C CA . THR A 1 346 ? -19.421 -53.092 -0.726 1.00 39.53 ? 346 THR A CA 1 ATOM 2651 C C . THR A 1 346 ? -17.982 -52.588 -0.856 1.00 39.26 ? 346 THR A C 1 ATOM 2652 O O . THR A 1 346 ? -17.483 -52.289 -1.956 1.00 37.60 ? 346 THR A O 1 ATOM 2653 C CB . THR A 1 346 ? -19.314 -54.570 -0.345 1.00 39.58 ? 346 THR A CB 1 ATOM 2654 O OG1 . THR A 1 346 ? -18.811 -55.308 -1.464 1.00 42.48 ? 346 THR A OG1 1 ATOM 2655 C CG2 . THR A 1 346 ? -20.656 -55.109 0.087 1.00 40.04 ? 346 THR A CG2 1 ATOM 2656 N N . ARG A 1 347 ? -17.304 -52.532 0.285 1.00 38.80 ? 347 ARG A N 1 ATOM 2657 C CA . ARG A 1 347 ? -15.913 -52.156 0.272 1.00 38.85 ? 347 ARG A CA 1 ATOM 2658 C C . ARG A 1 347 ? -15.139 -52.945 -0.788 1.00 38.56 ? 347 ARG A C 1 ATOM 2659 O O . ARG A 1 347 ? -14.355 -52.379 -1.556 1.00 37.92 ? 347 ARG A O 1 ATOM 2660 C CB . ARG A 1 347 ? -15.305 -52.335 1.652 1.00 38.56 ? 347 ARG A CB 1 ATOM 2661 C CG . ARG A 1 347 ? -13.810 -52.413 1.628 1.00 40.65 ? 347 ARG A CG 1 ATOM 2662 C CD . ARG A 1 347 ? -13.284 -52.341 3.043 1.00 43.41 ? 347 ARG A CD 1 ATOM 2663 N NE . ARG A 1 347 ? -11.884 -51.927 3.126 1.00 45.54 ? 347 ARG A NE 1 ATOM 2664 C CZ . ARG A 1 347 ? -11.468 -50.686 3.419 1.00 44.91 ? 347 ARG A CZ 1 ATOM 2665 N NH1 . ARG A 1 347 ? -10.164 -50.451 3.493 1.00 43.75 ? 347 ARG A NH1 1 ATOM 2666 N NH2 . ARG A 1 347 ? -12.340 -49.690 3.645 1.00 42.16 ? 347 ARG A NH2 1 ATOM 2667 N N . LYS A 1 348 ? -15.373 -54.257 -0.844 1.00 39.32 ? 348 LYS A N 1 ATOM 2668 C CA . LYS A 1 348 ? -14.621 -55.138 -1.752 1.00 40.35 ? 348 LYS A CA 1 ATOM 2669 C C . LYS A 1 348 ? -14.931 -54.819 -3.218 1.00 39.45 ? 348 LYS A C 1 ATOM 2670 O O . LYS A 1 348 ? -14.062 -54.840 -4.078 1.00 39.44 ? 348 LYS A O 1 ATOM 2671 C CB . LYS A 1 348 ? -14.895 -56.623 -1.414 1.00 41.19 ? 348 LYS A CB 1 ATOM 2672 C CG . LYS A 1 348 ? -13.999 -57.631 -2.168 1.00 46.19 ? 348 LYS A CG 1 ATOM 2673 C CD . LYS A 1 348 ? -12.480 -57.272 -2.028 1.00 51.13 ? 348 LYS A CD 1 ATOM 2674 C CE . LYS A 1 348 ? -11.666 -57.637 -3.310 1.00 52.47 ? 348 LYS A CE 1 ATOM 2675 N NZ . LYS A 1 348 ? -10.452 -56.741 -3.541 1.00 52.13 ? 348 LYS A NZ 1 ATOM 2676 N N . GLU A 1 349 ? -16.202 -54.525 -3.477 1.00 39.69 ? 349 GLU A N 1 ATOM 2677 C CA . GLU A 1 349 ? -16.679 -54.007 -4.781 1.00 38.87 ? 349 GLU A CA 1 ATOM 2678 C C . GLU A 1 349 ? -16.023 -52.657 -5.153 1.00 37.54 ? 349 GLU A C 1 ATOM 2679 O O . GLU A 1 349 ? -15.492 -52.492 -6.266 1.00 36.24 ? 349 GLU A O 1 ATOM 2680 C CB . GLU A 1 349 ? -18.224 -53.937 -4.781 1.00 39.02 ? 349 GLU A CB 1 ATOM 2681 C CG . GLU A 1 349 ? -18.885 -55.290 -5.206 1.00 41.60 ? 349 GLU A CG 1 ATOM 2682 C CD . GLU A 1 349 ? -20.364 -55.418 -4.825 1.00 42.24 ? 349 GLU A CD 1 ATOM 2683 O OE1 . GLU A 1 349 ? -21.066 -56.218 -5.472 1.00 45.88 ? 349 GLU A OE1 1 ATOM 2684 O OE2 . GLU A 1 349 ? -20.837 -54.728 -3.905 1.00 41.34 ? 349 GLU A OE2 1 ATOM 2685 N N . PHE A 1 350 ? -16.023 -51.717 -4.204 1.00 36.38 ? 350 PHE A N 1 ATOM 2686 C CA . PHE A 1 350 ? -15.321 -50.441 -4.388 1.00 35.49 ? 350 PHE A CA 1 ATOM 2687 C C . PHE A 1 350 ? -13.900 -50.659 -4.849 1.00 35.70 ? 350 PHE A C 1 ATOM 2688 O O . PHE A 1 350 ? -13.441 -50.049 -5.825 1.00 35.64 ? 350 PHE A O 1 ATOM 2689 C CB . PHE A 1 350 ? -15.321 -49.653 -3.115 1.00 35.34 ? 350 PHE A CB 1 ATOM 2690 C CG . PHE A 1 350 ? -14.547 -48.361 -3.195 1.00 35.93 ? 350 PHE A CG 1 ATOM 2691 C CD1 . PHE A 1 350 ? -15.181 -47.172 -3.574 1.00 33.83 ? 350 PHE A CD1 1 ATOM 2692 C CD2 . PHE A 1 350 ? -13.179 -48.311 -2.835 1.00 34.98 ? 350 PHE A CD2 1 ATOM 2693 C CE1 . PHE A 1 350 ? -14.458 -45.937 -3.617 1.00 32.97 ? 350 PHE A CE1 1 ATOM 2694 C CE2 . PHE A 1 350 ? -12.453 -47.067 -2.878 1.00 34.10 ? 350 PHE A CE2 1 ATOM 2695 C CZ . PHE A 1 350 ? -13.094 -45.897 -3.251 1.00 31.53 ? 350 PHE A CZ 1 ATOM 2696 N N . GLN A 1 351 ? -13.197 -51.567 -4.171 1.00 35.82 ? 351 GLN A N 1 ATOM 2697 C CA . GLN A 1 351 ? -11.826 -51.883 -4.546 1.00 36.02 ? 351 GLN A CA 1 ATOM 2698 C C . GLN A 1 351 ? -11.732 -52.498 -5.938 1.00 35.69 ? 351 GLN A C 1 ATOM 2699 O O . GLN A 1 351 ? -10.800 -52.209 -6.711 1.00 34.11 ? 351 GLN A O 1 ATOM 2700 C CB . GLN A 1 351 ? -11.199 -52.799 -3.479 1.00 36.42 ? 351 GLN A CB 1 ATOM 2701 C CG . GLN A 1 351 ? -11.193 -52.165 -2.090 1.00 39.62 ? 351 GLN A CG 1 ATOM 2702 C CD . GLN A 1 351 ? -10.626 -53.101 -1.020 1.00 42.78 ? 351 GLN A CD 1 ATOM 2703 O OE1 . GLN A 1 351 ? -11.256 -54.090 -0.626 1.00 43.50 ? 351 GLN A OE1 1 ATOM 2704 N NE2 . GLN A 1 351 ? -9.431 -52.798 -0.562 1.00 42.24 ? 351 GLN A NE2 1 ATOM 2705 N N . GLU A 1 352 ? -12.700 -53.361 -6.272 1.00 36.24 ? 352 GLU A N 1 ATOM 2706 C CA . GLU A 1 352 ? -12.732 -53.925 -7.635 1.00 36.23 ? 352 GLU A CA 1 ATOM 2707 C C . GLU A 1 352 ? -12.954 -52.810 -8.659 1.00 34.47 ? 352 GLU A C 1 ATOM 2708 O O . GLU A 1 352 ? -12.323 -52.810 -9.724 1.00 33.82 ? 352 GLU A O 1 ATOM 2709 C CB . GLU A 1 352 ? -13.809 -55.019 -7.764 1.00 38.01 ? 352 GLU A CB 1 ATOM 2710 C CG . GLU A 1 352 ? -13.465 -56.354 -7.057 1.00 43.28 ? 352 GLU A CG 1 ATOM 2711 C CD . GLU A 1 352 ? -12.002 -56.802 -7.291 1.00 52.12 ? 352 GLU A CD 1 ATOM 2712 O OE1 . GLU A 1 352 ? -11.279 -57.048 -6.264 1.00 56.21 ? 352 GLU A OE1 1 ATOM 2713 O OE2 . GLU A 1 352 ? -11.569 -56.883 -8.488 1.00 53.66 ? 352 GLU A OE2 1 ATOM 2714 N N . GLY A 1 353 ? -13.812 -51.847 -8.316 1.00 32.59 ? 353 GLY A N 1 ATOM 2715 C CA . GLY A 1 353 ? -14.072 -50.669 -9.200 1.00 32.78 ? 353 GLY A CA 1 ATOM 2716 C C . GLY A 1 353 ? -12.821 -49.872 -9.536 1.00 32.69 ? 353 GLY A C 1 ATOM 2717 O O . GLY A 1 353 ? -12.671 -49.409 -10.679 1.00 33.72 ? 353 GLY A O 1 ATOM 2718 N N . LEU A 1 354 ? -11.915 -49.717 -8.542 1.00 32.09 ? 354 LEU A N 1 ATOM 2719 C CA . LEU A 1 354 ? -10.682 -48.955 -8.716 1.00 31.34 ? 354 LEU A CA 1 ATOM 2720 C C . LEU A 1 354 ? -9.863 -49.679 -9.748 1.00 31.88 ? 354 LEU A C 1 ATOM 2721 O O . LEU A 1 354 ? -9.275 -49.054 -10.626 1.00 31.29 ? 354 LEU A O 1 ATOM 2722 C CB . LEU A 1 354 ? -9.879 -48.802 -7.422 1.00 30.56 ? 354 LEU A CB 1 ATOM 2723 C CG . LEU A 1 354 ? -10.474 -47.957 -6.302 1.00 31.05 ? 354 LEU A CG 1 ATOM 2724 C CD1 . LEU A 1 354 ? -9.544 -47.824 -5.122 1.00 32.42 ? 354 LEU A CD1 1 ATOM 2725 C CD2 . LEU A 1 354 ? -10.778 -46.577 -6.837 1.00 30.67 ? 354 LEU A CD2 1 ATOM 2726 N N . LYS A 1 355 ? -9.859 -51.007 -9.683 1.00 32.64 ? 355 LYS A N 1 ATOM 2727 C CA . LYS A 1 355 ? -9.189 -51.778 -10.743 1.00 33.16 ? 355 LYS A CA 1 ATOM 2728 C C . LYS A 1 355 ? -9.758 -51.500 -12.135 1.00 32.68 ? 355 LYS A C 1 ATOM 2729 O O . LYS A 1 355 ? -9.011 -51.355 -13.090 1.00 32.94 ? 355 LYS A O 1 ATOM 2730 C CB . LYS A 1 355 ? -9.212 -53.268 -10.421 1.00 34.00 ? 355 LYS A CB 1 ATOM 2731 C CG . LYS A 1 355 ? -8.247 -53.607 -9.353 1.00 37.94 ? 355 LYS A CG 1 ATOM 2732 C CD . LYS A 1 355 ? -8.372 -55.073 -8.876 1.00 47.03 ? 355 LYS A CD 1 ATOM 2733 C CE . LYS A 1 355 ? -9.040 -55.110 -7.491 1.00 51.51 ? 355 LYS A CE 1 ATOM 2734 N NZ . LYS A 1 355 ? -8.753 -56.336 -6.681 1.00 54.69 ? 355 LYS A NZ 1 ATOM 2735 N N . ILE A 1 356 ? -11.083 -51.426 -12.257 1.00 33.74 ? 356 ILE A N 1 ATOM 2736 C CA . ILE A 1 356 ? -11.707 -51.102 -13.537 1.00 34.42 ? 356 ILE A CA 1 ATOM 2737 C C . ILE A 1 356 ? -11.212 -49.724 -13.983 1.00 34.06 ? 356 ILE A C 1 ATOM 2738 O O . ILE A 1 356 ? -10.771 -49.555 -15.097 1.00 34.61 ? 356 ILE A O 1 ATOM 2739 C CB . ILE A 1 356 ? -13.249 -51.069 -13.406 1.00 34.96 ? 356 ILE A CB 1 ATOM 2740 C CG1 . ILE A 1 356 ? -13.822 -52.455 -13.071 1.00 36.89 ? 356 ILE A CG1 1 ATOM 2741 C CG2 . ILE A 1 356 ? -13.886 -50.508 -14.675 1.00 35.66 ? 356 ILE A CG2 1 ATOM 2742 C CD1 . ILE A 1 356 ? -13.260 -53.564 -13.860 1.00 39.35 ? 356 ILE A CD1 1 ATOM 2743 N N . PHE A 1 357 ? -11.216 -48.736 -13.080 1.00 33.67 ? 357 PHE A N 1 ATOM 2744 C CA . PHE A 1 357 ? -10.909 -47.374 -13.493 1.00 31.83 ? 357 PHE A CA 1 ATOM 2745 C C . PHE A 1 357 ? -9.436 -46.989 -13.463 1.00 32.60 ? 357 PHE A C 1 ATOM 2746 O O . PHE A 1 357 ? -9.040 -46.004 -14.072 1.00 31.45 ? 357 PHE A O 1 ATOM 2747 C CB . PHE A 1 357 ? -11.760 -46.422 -12.654 1.00 32.54 ? 357 PHE A CB 1 ATOM 2748 C CG . PHE A 1 357 ? -13.176 -46.340 -13.139 1.00 30.31 ? 357 PHE A CG 1 ATOM 2749 C CD1 . PHE A 1 357 ? -13.474 -45.618 -14.296 1.00 30.20 ? 357 PHE A CD1 1 ATOM 2750 C CD2 . PHE A 1 357 ? -14.181 -47.026 -12.493 1.00 31.09 ? 357 PHE A CD2 1 ATOM 2751 C CE1 . PHE A 1 357 ? -14.781 -45.568 -14.792 1.00 28.66 ? 357 PHE A CE1 1 ATOM 2752 C CE2 . PHE A 1 357 ? -15.509 -46.994 -12.977 1.00 33.22 ? 357 PHE A CE2 1 ATOM 2753 C CZ . PHE A 1 357 ? -15.809 -46.261 -14.124 1.00 28.85 ? 357 PHE A CZ 1 ATOM 2754 N N . PHE A 1 358 ? -8.611 -47.762 -12.760 1.00 33.57 ? 358 PHE A N 1 ATOM 2755 C CA . PHE A 1 358 ? -7.188 -47.431 -12.652 1.00 34.88 ? 358 PHE A CA 1 ATOM 2756 C C . PHE A 1 358 ? -6.287 -48.669 -12.948 1.00 37.83 ? 358 PHE A C 1 ATOM 2757 O O . PHE A 1 358 ? -5.460 -49.060 -12.127 1.00 38.33 ? 358 PHE A O 1 ATOM 2758 C CB . PHE A 1 358 ? -6.877 -46.814 -11.269 1.00 33.21 ? 358 PHE A CB 1 ATOM 2759 C CG . PHE A 1 358 ? -7.643 -45.519 -10.961 1.00 28.94 ? 358 PHE A CG 1 ATOM 2760 C CD1 . PHE A 1 358 ? -7.105 -44.270 -11.267 1.00 25.19 ? 358 PHE A CD1 1 ATOM 2761 C CD2 . PHE A 1 358 ? -8.890 -45.556 -10.375 1.00 26.35 ? 358 PHE A CD2 1 ATOM 2762 C CE1 . PHE A 1 358 ? -7.785 -43.097 -10.957 1.00 18.97 ? 358 PHE A CE1 1 ATOM 2763 C CE2 . PHE A 1 358 ? -9.582 -44.379 -10.076 1.00 23.97 ? 358 PHE A CE2 1 ATOM 2764 C CZ . PHE A 1 358 ? -9.021 -43.163 -10.398 1.00 23.21 ? 358 PHE A CZ 1 ATOM 2765 N N . PRO A 1 359 ? -6.469 -49.279 -14.130 1.00 40.12 ? 359 PRO A N 1 ATOM 2766 C CA . PRO A 1 359 ? -5.758 -50.362 -14.798 1.00 42.05 ? 359 PRO A CA 1 ATOM 2767 C C . PRO A 1 359 ? -4.341 -50.642 -14.360 1.00 43.03 ? 359 PRO A C 1 ATOM 2768 O O . PRO A 1 359 ? -4.039 -51.749 -13.919 1.00 43.81 ? 359 PRO A O 1 ATOM 2769 C CB . PRO A 1 359 ? -5.780 -49.909 -16.251 1.00 42.43 ? 359 PRO A CB 1 ATOM 2770 C CG . PRO A 1 359 ? -7.211 -49.462 -16.392 1.00 41.67 ? 359 PRO A CG 1 ATOM 2771 C CD . PRO A 1 359 ? -7.564 -48.810 -14.998 1.00 40.89 ? 359 PRO A CD 1 ATOM 2772 N N . GLY A 1 360 ? -3.442 -49.699 -14.460 1.00 43.89 ? 360 GLY A N 1 ATOM 2773 C CA . GLY A 1 360 ? -2.280 -49.936 -13.605 1.00 45.11 ? 360 GLY A CA 1 ATOM 2774 C C . GLY A 1 360 ? -1.248 -48.869 -13.569 1.00 44.49 ? 360 GLY A C 1 ATOM 2775 O O . GLY A 1 360 ? -0.297 -48.899 -14.341 1.00 45.42 ? 360 GLY A O 1 ATOM 2776 N N . VAL A 1 361 ? -1.326 -47.951 -12.631 1.00 44.23 ? 361 VAL A N 1 ATOM 2777 C CA . VAL A 1 361 ? -1.787 -48.047 -11.246 1.00 41.72 ? 361 VAL A CA 1 ATOM 2778 C C . VAL A 1 361 ? -1.325 -49.052 -10.229 1.00 40.97 ? 361 VAL A C 1 ATOM 2779 O O . VAL A 1 361 ? -1.997 -50.077 -9.969 1.00 40.72 ? 361 VAL A O 1 ATOM 2780 C CB . VAL A 1 361 ? -3.042 -47.199 -10.868 1.00 41.39 ? 361 VAL A CB 1 ATOM 2781 C CG1 . VAL A 1 361 ? -2.776 -46.576 -9.541 1.00 40.18 ? 361 VAL A CG1 1 ATOM 2782 C CG2 . VAL A 1 361 ? -3.245 -46.059 -11.893 1.00 39.86 ? 361 VAL A CG2 1 ATOM 2783 N N . SER A 1 362 ? -0.164 -48.772 -9.637 1.00 38.18 ? 362 SER A N 1 ATOM 2784 C CA . SER A 1 362 ? 0.338 -49.610 -8.586 1.00 37.07 ? 362 SER A CA 1 ATOM 2785 C C . SER A 1 362 ? -0.727 -49.898 -7.533 1.00 36.92 ? 362 SER A C 1 ATOM 2786 O O . SER A 1 362 ? -1.718 -49.170 -7.367 1.00 36.95 ? 362 SER A O 1 ATOM 2787 C CB . SER A 1 362 ? 1.557 -48.944 -7.954 1.00 37.20 ? 362 SER A CB 1 ATOM 2788 O OG . SER A 1 362 ? 1.256 -47.679 -7.389 1.00 36.10 ? 362 SER A OG 1 ATOM 2789 N N . GLU A 1 363 ? -0.551 -50.986 -6.829 1.00 36.59 ? 363 GLU A N 1 ATOM 2790 C CA . GLU A 1 363 ? -1.371 -51.262 -5.683 1.00 37.25 ? 363 GLU A CA 1 ATOM 2791 C C . GLU A 1 363 ? -1.373 -50.102 -4.678 1.00 35.75 ? 363 GLU A C 1 ATOM 2792 O O . GLU A 1 363 ? -2.395 -49.814 -4.022 1.00 36.06 ? 363 GLU A O 1 ATOM 2793 C CB . GLU A 1 363 ? -0.845 -52.527 -5.006 1.00 38.00 ? 363 GLU A CB 1 ATOM 2794 C CG . GLU A 1 363 ? -1.974 -53.448 -4.592 1.00 45.42 ? 363 GLU A CG 1 ATOM 2795 C CD . GLU A 1 363 ? -2.859 -53.903 -5.800 1.00 52.33 ? 363 GLU A CD 1 ATOM 2796 O OE1 . GLU A 1 363 ? -2.369 -53.967 -6.965 1.00 53.48 ? 363 GLU A OE1 1 ATOM 2797 O OE2 . GLU A 1 363 ? -4.055 -54.204 -5.573 1.00 55.13 ? 363 GLU A OE2 1 ATOM 2798 N N . PHE A 1 364 ? -0.206 -49.479 -4.510 1.00 34.13 ? 364 PHE A N 1 ATOM 2799 C CA . PHE A 1 364 ? -0.054 -48.367 -3.575 1.00 32.46 ? 364 PHE A CA 1 ATOM 2800 C C . PHE A 1 364 ? -0.892 -47.204 -4.117 1.00 31.40 ? 364 PHE A C 1 ATOM 2801 O O . PHE A 1 364 ? -1.695 -46.638 -3.399 1.00 31.26 ? 364 PHE A O 1 ATOM 2802 C CB . PHE A 1 364 ? 1.431 -47.961 -3.433 1.00 32.61 ? 364 PHE A CB 1 ATOM 2803 C CG . PHE A 1 364 ? 1.629 -46.671 -2.685 1.00 31.33 ? 364 PHE A CG 1 ATOM 2804 C CD1 . PHE A 1 364 ? 2.060 -45.532 -3.330 1.00 30.15 ? 364 PHE A CD1 1 ATOM 2805 C CD2 . PHE A 1 364 ? 1.335 -46.586 -1.346 1.00 30.59 ? 364 PHE A CD2 1 ATOM 2806 C CE1 . PHE A 1 364 ? 2.202 -44.343 -2.634 1.00 27.40 ? 364 PHE A CE1 1 ATOM 2807 C CE2 . PHE A 1 364 ? 1.468 -45.396 -0.682 1.00 30.78 ? 364 PHE A CE2 1 ATOM 2808 C CZ . PHE A 1 364 ? 1.891 -44.289 -1.330 1.00 28.57 ? 364 PHE A CZ 1 ATOM 2809 N N . GLY A 1 365 ? -0.723 -46.860 -5.395 1.00 30.73 ? 365 GLY A N 1 ATOM 2810 C CA . GLY A 1 365 ? -1.626 -45.895 -6.046 1.00 29.16 ? 365 GLY A CA 1 ATOM 2811 C C . GLY A 1 365 ? -3.100 -46.118 -5.690 1.00 29.43 ? 365 GLY A C 1 ATOM 2812 O O . GLY A 1 365 ? -3.798 -45.196 -5.197 1.00 28.65 ? 365 GLY A O 1 ATOM 2813 N N . LYS A 1 366 ? -3.590 -47.341 -5.889 1.00 28.46 ? 366 LYS A N 1 ATOM 2814 C CA . LYS A 1 366 ? -4.996 -47.603 -5.616 1.00 28.94 ? 366 LYS A CA 1 ATOM 2815 C C . LYS A 1 366 ? -5.344 -47.548 -4.129 1.00 29.29 ? 366 LYS A C 1 ATOM 2816 O O . LYS A 1 366 ? -6.454 -47.125 -3.803 1.00 28.01 ? 366 LYS A O 1 ATOM 2817 C CB . LYS A 1 366 ? -5.488 -48.934 -6.238 1.00 29.70 ? 366 LYS A CB 1 ATOM 2818 C CG . LYS A 1 366 ? -5.181 -49.102 -7.755 1.00 32.46 ? 366 LYS A CG 1 ATOM 2819 C CD . LYS A 1 366 ? -6.015 -50.225 -8.378 1.00 36.91 ? 366 LYS A CD 1 ATOM 2820 C CE . LYS A 1 366 ? -5.200 -51.487 -8.568 1.00 38.71 ? 366 LYS A CE 1 ATOM 2821 N NZ . LYS A 1 366 ? -3.816 -51.079 -8.895 1.00 41.60 ? 366 LYS A NZ 1 ATOM 2822 N N . GLU A 1 367 ? -4.449 -47.985 -3.219 1.00 29.33 ? 367 GLU A N 1 ATOM 2823 C CA . GLU A 1 367 ? -4.734 -47.866 -1.754 1.00 30.99 ? 367 GLU A CA 1 ATOM 2824 C C . GLU A 1 367 ? -4.882 -46.404 -1.339 1.00 29.22 ? 367 GLU A C 1 ATOM 2825 O O . GLU A 1 367 ? -5.702 -46.032 -0.466 1.00 27.90 ? 367 GLU A O 1 ATOM 2826 C CB . GLU A 1 367 ? -3.594 -48.430 -0.905 1.00 31.73 ? 367 GLU A CB 1 ATOM 2827 C CG . GLU A 1 367 ? -3.838 -49.820 -0.405 1.00 41.31 ? 367 GLU A CG 1 ATOM 2828 C CD . GLU A 1 367 ? -4.708 -49.850 0.868 1.00 51.68 ? 367 GLU A CD 1 ATOM 2829 O OE1 . GLU A 1 367 ? -4.320 -49.238 1.902 1.00 56.43 ? 367 GLU A OE1 1 ATOM 2830 O OE2 . GLU A 1 367 ? -5.779 -50.515 0.851 1.00 54.46 ? 367 GLU A OE2 1 ATOM 2831 N N . SER A 1 368 ? -4.086 -45.577 -2.000 1.00 28.04 ? 368 SER A N 1 ATOM 2832 C CA . SER A 1 368 ? -4.047 -44.174 -1.677 1.00 28.02 ? 368 SER A CA 1 ATOM 2833 C C . SER A 1 368 ? -5.372 -43.492 -2.015 1.00 28.21 ? 368 SER A C 1 ATOM 2834 O O . SER A 1 368 ? -5.891 -42.672 -1.216 1.00 27.76 ? 368 SER A O 1 ATOM 2835 C CB . SER A 1 368 ? -2.838 -43.539 -2.343 1.00 27.98 ? 368 SER A CB 1 ATOM 2836 O OG . SER A 1 368 ? -3.130 -43.068 -3.633 1.00 28.54 ? 368 SER A OG 1 ATOM 2837 N N . ILE A 1 369 ? -5.982 -43.882 -3.154 1.00 28.13 ? 369 ILE A N 1 ATOM 2838 C CA . ILE A 1 369 ? -7.332 -43.418 -3.460 1.00 26.85 ? 369 ILE A CA 1 ATOM 2839 C C . ILE A 1 369 ? -8.269 -43.909 -2.374 1.00 26.78 ? 369 ILE A C 1 ATOM 2840 O O . ILE A 1 369 ? -9.037 -43.160 -1.758 1.00 26.29 ? 369 ILE A O 1 ATOM 2841 C CB . ILE A 1 369 ? -7.817 -43.914 -4.853 1.00 27.15 ? 369 ILE A CB 1 ATOM 2842 C CG1 . ILE A 1 369 ? -6.865 -43.475 -5.962 1.00 26.43 ? 369 ILE A CG1 1 ATOM 2843 C CG2 . ILE A 1 369 ? -9.208 -43.460 -5.108 1.00 26.77 ? 369 ILE A CG2 1 ATOM 2844 C CD1 . ILE A 1 369 ? -7.119 -44.180 -7.330 1.00 27.29 ? 369 ILE A CD1 1 ATOM 2845 N N . LEU A 1 370 ? -8.217 -45.195 -2.108 1.00 27.55 ? 370 LEU A N 1 ATOM 2846 C CA . LEU A 1 370 ? -9.047 -45.713 -1.087 1.00 28.14 ? 370 LEU A CA 1 ATOM 2847 C C . LEU A 1 370 ? -8.857 -44.969 0.231 1.00 28.47 ? 370 LEU A C 1 ATOM 2848 O O . LEU A 1 370 ? -9.833 -44.539 0.837 1.00 28.36 ? 370 LEU A O 1 ATOM 2849 C CB . LEU A 1 370 ? -8.774 -47.206 -0.925 1.00 29.55 ? 370 LEU A CB 1 ATOM 2850 C CG . LEU A 1 370 ? -9.741 -47.749 0.129 1.00 30.97 ? 370 LEU A CG 1 ATOM 2851 C CD1 . LEU A 1 370 ? -10.626 -48.829 -0.426 1.00 31.03 ? 370 LEU A CD1 1 ATOM 2852 C CD2 . LEU A 1 370 ? -8.967 -48.264 1.278 1.00 34.07 ? 370 LEU A CD2 1 ATOM 2853 N N . PHE A 1 371 ? -7.614 -44.795 0.691 1.00 29.65 ? 371 PHE A N 1 ATOM 2854 C CA A PHE A 1 371 ? -7.356 -44.035 1.917 0.30 30.21 ? 371 PHE A CA 1 ATOM 2855 C CA B PHE A 1 371 ? -7.372 -44.041 1.946 0.70 30.44 ? 371 PHE A CA 1 ATOM 2856 C C . PHE A 1 371 ? -8.018 -42.662 1.859 1.00 30.48 ? 371 PHE A C 1 ATOM 2857 O O . PHE A 1 371 ? -8.719 -42.222 2.806 1.00 30.69 ? 371 PHE A O 1 ATOM 2858 C CB A PHE A 1 371 ? -5.843 -43.889 2.147 0.30 30.28 ? 371 PHE A CB 1 ATOM 2859 C CB B PHE A 1 371 ? -5.863 -43.881 2.272 0.70 30.45 ? 371 PHE A CB 1 ATOM 2860 C CG A PHE A 1 371 ? -5.370 -42.459 2.253 0.30 31.32 ? 371 PHE A CG 1 ATOM 2861 C CG B PHE A 1 371 ? -5.577 -43.164 3.605 0.70 32.64 ? 371 PHE A CG 1 ATOM 2862 C CD1 A PHE A 1 371 ? -4.588 -41.900 1.252 0.30 32.36 ? 371 PHE A CD1 1 ATOM 2863 C CD1 B PHE A 1 371 ? -5.092 -41.851 3.634 0.70 34.65 ? 371 PHE A CD1 1 ATOM 2864 C CD2 A PHE A 1 371 ? -5.697 -41.674 3.350 0.30 33.13 ? 371 PHE A CD2 1 ATOM 2865 C CD2 B PHE A 1 371 ? -5.781 -43.813 4.824 0.70 33.42 ? 371 PHE A CD2 1 ATOM 2866 C CE1 A PHE A 1 371 ? -4.141 -40.598 1.335 0.30 33.68 ? 371 PHE A CE1 1 ATOM 2867 C CE1 B PHE A 1 371 ? -4.836 -41.177 4.875 0.70 33.48 ? 371 PHE A CE1 1 ATOM 2868 C CE2 A PHE A 1 371 ? -5.257 -40.352 3.437 0.30 33.41 ? 371 PHE A CE2 1 ATOM 2869 C CE2 B PHE A 1 371 ? -5.535 -43.148 6.067 0.70 35.73 ? 371 PHE A CE2 1 ATOM 2870 C CZ A PHE A 1 371 ? -4.482 -39.816 2.425 0.30 33.42 ? 371 PHE A CZ 1 ATOM 2871 C CZ B PHE A 1 371 ? -5.050 -41.848 6.092 0.70 32.69 ? 371 PHE A CZ 1 ATOM 2872 N N . HIS A 1 372 ? -7.811 -41.954 0.758 1.00 30.21 ? 372 HIS A N 1 ATOM 2873 C CA A HIS A 1 372 ? -8.362 -40.588 0.666 0.50 31.00 ? 372 HIS A CA 1 ATOM 2874 C CA B HIS A 1 372 ? -8.352 -40.604 0.729 0.50 31.21 ? 372 HIS A CA 1 ATOM 2875 C C . HIS A 1 372 ? -9.895 -40.532 0.612 1.00 32.07 ? 372 HIS A C 1 ATOM 2876 O O . HIS A 1 372 ? -10.525 -39.624 1.174 1.00 32.66 ? 372 HIS A O 1 ATOM 2877 C CB A HIS A 1 372 ? -7.767 -39.789 -0.488 0.50 30.60 ? 372 HIS A CB 1 ATOM 2878 C CB B HIS A 1 372 ? -7.566 -39.720 -0.235 0.50 31.03 ? 372 HIS A CB 1 ATOM 2879 C CG A HIS A 1 372 ? -8.114 -38.330 -0.436 0.50 29.67 ? 372 HIS A CG 1 ATOM 2880 C CG B HIS A 1 372 ? -6.221 -39.317 0.307 0.50 30.66 ? 372 HIS A CG 1 ATOM 2881 N ND1 A HIS A 1 372 ? -7.305 -37.388 0.165 0.50 28.19 ? 372 HIS A ND1 1 ATOM 2882 N ND1 B HIS A 1 372 ? -5.061 -40.008 0.022 0.50 30.20 ? 372 HIS A ND1 1 ATOM 2883 C CD2 A HIS A 1 372 ? -9.203 -37.658 -0.882 0.50 29.14 ? 372 HIS A CD2 1 ATOM 2884 C CD2 B HIS A 1 372 ? -5.861 -38.314 1.147 0.50 29.12 ? 372 HIS A CD2 1 ATOM 2885 C CE1 A HIS A 1 372 ? -7.871 -36.199 0.069 0.50 26.82 ? 372 HIS A CE1 1 ATOM 2886 C CE1 B HIS A 1 372 ? -4.042 -39.429 0.634 0.50 29.63 ? 372 HIS A CE1 1 ATOM 2887 N NE2 A HIS A 1 372 ? -9.027 -36.337 -0.554 0.50 26.95 ? 372 HIS A NE2 1 ATOM 2888 N NE2 B HIS A 1 372 ? -4.504 -38.411 1.340 0.50 28.69 ? 372 HIS A NE2 1 ATOM 2889 N N . TYR A 1 373 ? -10.529 -41.515 -0.011 1.00 32.28 ? 373 TYR A N 1 ATOM 2890 C CA . TYR A 1 373 ? -11.964 -41.378 -0.177 1.00 34.62 ? 373 TYR A CA 1 ATOM 2891 C C . TYR A 1 373 ? -12.837 -42.171 0.783 1.00 37.32 ? 373 TYR A C 1 ATOM 2892 O O . TYR A 1 373 ? -14.048 -42.123 0.650 1.00 38.23 ? 373 TYR A O 1 ATOM 2893 C CB . TYR A 1 373 ? -12.353 -41.684 -1.639 1.00 32.88 ? 373 TYR A CB 1 ATOM 2894 C CG . TYR A 1 373 ? -12.136 -40.507 -2.576 1.00 31.71 ? 373 TYR A CG 1 ATOM 2895 C CD1 . TYR A 1 373 ? -13.187 -39.641 -2.910 1.00 29.87 ? 373 TYR A CD1 1 ATOM 2896 C CD2 . TYR A 1 373 ? -10.894 -40.252 -3.121 1.00 27.31 ? 373 TYR A CD2 1 ATOM 2897 C CE1 . TYR A 1 373 ? -12.981 -38.531 -3.787 1.00 29.19 ? 373 TYR A CE1 1 ATOM 2898 C CE2 . TYR A 1 373 ? -10.697 -39.178 -4.015 1.00 27.31 ? 373 TYR A CE2 1 ATOM 2899 C CZ . TYR A 1 373 ? -11.752 -38.324 -4.335 1.00 26.29 ? 373 TYR A CZ 1 ATOM 2900 O OH . TYR A 1 373 ? -11.550 -37.244 -5.169 1.00 25.51 ? 373 TYR A OH 1 ATOM 2901 N N . THR A 1 374 ? -12.268 -42.904 1.741 1.00 40.75 ? 374 THR A N 1 ATOM 2902 C CA . THR A 1 374 ? -13.119 -43.781 2.558 1.00 44.73 ? 374 THR A CA 1 ATOM 2903 C C . THR A 1 374 ? -12.979 -43.607 4.042 1.00 47.87 ? 374 THR A C 1 ATOM 2904 O O . THR A 1 374 ? -13.308 -44.507 4.819 1.00 48.01 ? 374 THR A O 1 ATOM 2905 C CB . THR A 1 374 ? -12.912 -45.260 2.256 1.00 44.84 ? 374 THR A CB 1 ATOM 2906 O OG1 . THR A 1 374 ? -11.539 -45.581 2.488 1.00 43.94 ? 374 THR A OG1 1 ATOM 2907 C CG2 . THR A 1 374 ? -13.272 -45.541 0.808 1.00 45.93 ? 374 THR A CG2 1 ATOM 2908 N N . ASP A 1 375 ? -12.483 -42.453 4.447 1.00 51.39 ? 375 ASP A N 1 ATOM 2909 C CA . ASP A 1 375 ? -12.634 -42.068 5.823 1.00 54.84 ? 375 ASP A CA 1 ATOM 2910 C C . ASP A 1 375 ? -14.029 -41.448 6.092 1.00 56.49 ? 375 ASP A C 1 ATOM 2911 O O . ASP A 1 375 ? -14.203 -40.213 6.075 1.00 56.64 ? 375 ASP A O 1 ATOM 2912 C CB . ASP A 1 375 ? -11.568 -41.075 6.229 1.00 55.57 ? 375 ASP A CB 1 ATOM 2913 C CG . ASP A 1 375 ? -11.743 -40.676 7.646 1.00 57.61 ? 375 ASP A CG 1 ATOM 2914 O OD1 . ASP A 1 375 ? -11.831 -41.608 8.465 1.00 59.89 ? 375 ASP A OD1 1 ATOM 2915 O OD2 . ASP A 1 375 ? -11.880 -39.470 7.934 1.00 61.15 ? 375 ASP A OD2 1 ATOM 2916 N N . TRP A 1 376 ? -15.019 -42.302 6.340 1.00 58.31 ? 376 TRP A N 1 ATOM 2917 C CA . TRP A 1 376 ? -16.385 -41.842 6.537 1.00 59.65 ? 376 TRP A CA 1 ATOM 2918 C C . TRP A 1 376 ? -16.630 -41.084 7.824 1.00 61.87 ? 376 TRP A C 1 ATOM 2919 O O . TRP A 1 376 ? -15.982 -41.330 8.864 1.00 62.11 ? 376 TRP A O 1 ATOM 2920 C CB . TRP A 1 376 ? -17.338 -43.016 6.594 1.00 59.01 ? 376 TRP A CB 1 ATOM 2921 C CG . TRP A 1 376 ? -16.984 -44.119 5.724 1.00 56.67 ? 376 TRP A CG 1 ATOM 2922 C CD1 . TRP A 1 376 ? -16.672 -45.387 6.103 1.00 54.87 ? 376 TRP A CD1 1 ATOM 2923 C CD2 . TRP A 1 376 ? -16.920 -44.089 4.292 1.00 53.91 ? 376 TRP A CD2 1 ATOM 2924 N NE1 . TRP A 1 376 ? -16.414 -46.153 4.987 1.00 53.51 ? 376 TRP A NE1 1 ATOM 2925 C CE2 . TRP A 1 376 ? -16.560 -45.375 3.867 1.00 52.49 ? 376 TRP A CE2 1 ATOM 2926 C CE3 . TRP A 1 376 ? -17.121 -43.095 3.333 1.00 51.04 ? 376 TRP A CE3 1 ATOM 2927 C CZ2 . TRP A 1 376 ? -16.395 -45.688 2.531 1.00 50.81 ? 376 TRP A CZ2 1 ATOM 2928 C CZ3 . TRP A 1 376 ? -16.969 -43.416 2.022 1.00 48.95 ? 376 TRP A CZ3 1 ATOM 2929 C CH2 . TRP A 1 376 ? -16.615 -44.697 1.627 1.00 49.53 ? 376 TRP A CH2 1 ATOM 2930 N N . VAL A 1 377 ? -17.669 -40.258 7.733 1.00 63.94 ? 377 VAL A N 1 ATOM 2931 C CA . VAL A 1 377 ? -18.215 -39.483 8.822 1.00 65.95 ? 377 VAL A CA 1 ATOM 2932 C C . VAL A 1 377 ? -19.752 -39.579 8.841 1.00 67.15 ? 377 VAL A C 1 ATOM 2933 O O . VAL A 1 377 ? -20.421 -38.558 8.614 1.00 68.23 ? 377 VAL A O 1 ATOM 2934 C CB . VAL A 1 377 ? -17.819 -38.032 8.609 1.00 66.08 ? 377 VAL A CB 1 ATOM 2935 C CG1 . VAL A 1 377 ? -16.332 -37.975 8.273 1.00 67.06 ? 377 VAL A CG1 1 ATOM 2936 C CG2 . VAL A 1 377 ? -18.647 -37.417 7.452 1.00 66.18 ? 377 VAL A CG2 1 ATOM 2937 N N . ASP A 1 378 ? -20.325 -40.767 9.109 1.00 67.79 ? 378 ASP A N 1 ATOM 2938 C CA . ASP A 1 378 ? -19.553 -41.973 9.460 1.00 68.38 ? 378 ASP A CA 1 ATOM 2939 C C . ASP A 1 378 ? -19.977 -43.365 8.880 1.00 68.40 ? 378 ASP A C 1 ATOM 2940 O O . ASP A 1 378 ? -20.959 -43.516 8.133 1.00 68.77 ? 378 ASP A O 1 ATOM 2941 C CB . ASP A 1 378 ? -19.374 -42.085 10.983 1.00 68.54 ? 378 ASP A CB 1 ATOM 2942 C CG . ASP A 1 378 ? -18.106 -42.841 11.364 1.00 69.32 ? 378 ASP A CG 1 ATOM 2943 O OD1 . ASP A 1 378 ? -18.175 -44.086 11.608 1.00 69.80 ? 378 ASP A OD1 1 ATOM 2944 O OD2 . ASP A 1 378 ? -17.038 -42.180 11.374 1.00 68.52 ? 378 ASP A OD2 1 ATOM 2945 N N . ASP A 1 379 ? -19.198 -44.373 9.270 1.00 68.16 ? 379 ASP A N 1 ATOM 2946 C CA . ASP A 1 379 ? -19.172 -45.685 8.623 1.00 67.87 ? 379 ASP A CA 1 ATOM 2947 C C . ASP A 1 379 ? -20.555 -46.334 8.598 1.00 67.18 ? 379 ASP A C 1 ATOM 2948 O O . ASP A 1 379 ? -20.696 -47.519 8.271 1.00 66.73 ? 379 ASP A O 1 ATOM 2949 C CB . ASP A 1 379 ? -18.186 -46.572 9.381 1.00 68.34 ? 379 ASP A CB 1 ATOM 2950 C CG . ASP A 1 379 ? -18.700 -46.951 10.779 1.00 70.44 ? 379 ASP A CG 1 ATOM 2951 O OD1 . ASP A 1 379 ? -19.398 -46.121 11.421 1.00 71.66 ? 379 ASP A OD1 1 ATOM 2952 O OD2 . ASP A 1 379 ? -18.437 -48.099 11.214 1.00 71.93 ? 379 ASP A OD2 1 ATOM 2953 N N . GLN A 1 380 ? -21.571 -45.544 8.945 1.00 66.40 ? 380 GLN A N 1 ATOM 2954 C CA . GLN A 1 380 ? -22.948 -46.033 9.091 1.00 65.42 ? 380 GLN A CA 1 ATOM 2955 C C . GLN A 1 380 ? -23.715 -46.248 7.763 1.00 63.97 ? 380 GLN A C 1 ATOM 2956 O O . GLN A 1 380 ? -24.043 -47.391 7.374 1.00 63.75 ? 380 GLN A O 1 ATOM 2957 C CB . GLN A 1 380 ? -23.720 -45.039 9.959 1.00 66.18 ? 380 GLN A CB 1 ATOM 2958 C CG . GLN A 1 380 ? -23.134 -44.890 11.329 1.00 67.79 ? 380 GLN A CG 1 ATOM 2959 C CD . GLN A 1 380 ? -23.864 -45.745 12.351 1.00 71.00 ? 380 GLN A CD 1 ATOM 2960 O OE1 . GLN A 1 380 ? -23.260 -46.251 13.310 1.00 72.12 ? 380 GLN A OE1 1 ATOM 2961 N NE2 . GLN A 1 380 ? -25.175 -45.920 12.147 1.00 70.67 ? 380 GLN A NE2 1 ATOM 2962 N N . ARG A 1 381 ? -24.044 -45.112 7.143 1.00 61.45 ? 381 ARG A N 1 ATOM 2963 C CA . ARG A 1 381 ? -24.466 -44.947 5.740 1.00 58.76 ? 381 ARG A CA 1 ATOM 2964 C C . ARG A 1 381 ? -24.094 -46.056 4.747 1.00 56.15 ? 381 ARG A C 1 ATOM 2965 O O . ARG A 1 381 ? -22.941 -46.183 4.357 1.00 56.97 ? 381 ARG A O 1 ATOM 2966 C CB . ARG A 1 381 ? -23.882 -43.621 5.239 1.00 59.02 ? 381 ARG A CB 1 ATOM 2967 C CG . ARG A 1 381 ? -24.324 -42.369 6.041 1.00 60.88 ? 381 ARG A CG 1 ATOM 2968 C CD . ARG A 1 381 ? -24.826 -41.236 5.141 1.00 65.72 ? 381 ARG A CD 1 ATOM 2969 N NE . ARG A 1 381 ? -23.947 -41.011 3.992 1.00 70.26 ? 381 ARG A NE 1 ATOM 2970 C CZ . ARG A 1 381 ? -24.309 -41.094 2.710 1.00 70.76 ? 381 ARG A CZ 1 ATOM 2971 N NH1 . ARG A 1 381 ? -23.401 -40.877 1.773 1.00 70.81 ? 381 ARG A NH1 1 ATOM 2972 N NH2 . ARG A 1 381 ? -25.556 -41.409 2.369 1.00 69.74 ? 381 ARG A NH2 1 ATOM 2973 N N . PRO A 1 382 ? -25.080 -46.814 4.262 1.00 53.22 ? 382 PRO A N 1 ATOM 2974 C CA . PRO A 1 382 ? -24.813 -47.853 3.245 1.00 50.92 ? 382 PRO A CA 1 ATOM 2975 C C . PRO A 1 382 ? -24.418 -47.383 1.822 1.00 48.90 ? 382 PRO A C 1 ATOM 2976 O O . PRO A 1 382 ? -23.834 -48.165 1.066 1.00 47.88 ? 382 PRO A O 1 ATOM 2977 C CB . PRO A 1 382 ? -26.126 -48.648 3.182 1.00 50.73 ? 382 PRO A CB 1 ATOM 2978 C CG . PRO A 1 382 ? -27.156 -47.841 3.910 1.00 51.98 ? 382 PRO A CG 1 ATOM 2979 C CD . PRO A 1 382 ? -26.517 -46.596 4.490 1.00 53.14 ? 382 PRO A CD 1 ATOM 2980 N N . GLU A 1 383 ? -24.756 -46.153 1.439 1.00 47.12 ? 383 GLU A N 1 ATOM 2981 C CA . GLU A 1 383 ? -24.404 -45.662 0.082 1.00 46.13 ? 383 GLU A CA 1 ATOM 2982 C C . GLU A 1 383 ? -23.004 -45.047 0.036 1.00 44.33 ? 383 GLU A C 1 ATOM 2983 O O . GLU A 1 383 ? -22.603 -44.390 -0.955 1.00 43.26 ? 383 GLU A O 1 ATOM 2984 C CB . GLU A 1 383 ? -25.458 -44.688 -0.462 1.00 46.63 ? 383 GLU A CB 1 ATOM 2985 C CG . GLU A 1 383 ? -25.885 -43.573 0.485 1.00 51.23 ? 383 GLU A CG 1 ATOM 2986 C CD . GLU A 1 383 ? -26.690 -44.076 1.707 1.00 56.65 ? 383 GLU A CD 1 ATOM 2987 O OE1 . GLU A 1 383 ? -26.105 -44.121 2.811 1.00 58.41 ? 383 GLU A OE1 1 ATOM 2988 O OE2 . GLU A 1 383 ? -27.904 -44.428 1.577 1.00 59.84 ? 383 GLU A OE2 1 ATOM 2989 N N . ASN A 1 384 ? -22.269 -45.274 1.128 1.00 41.87 ? 384 ASN A N 1 ATOM 2990 C CA . ASN A 1 384 ? -20.926 -44.726 1.349 1.00 39.88 ? 384 ASN A CA 1 ATOM 2991 C C . ASN A 1 384 ? -19.974 -45.062 0.206 1.00 37.47 ? 384 ASN A C 1 ATOM 2992 O O . ASN A 1 384 ? -19.397 -44.186 -0.446 1.00 36.37 ? 384 ASN A O 1 ATOM 2993 C CB . ASN A 1 384 ? -20.341 -45.249 2.680 1.00 40.06 ? 384 ASN A CB 1 ATOM 2994 C CG . ASN A 1 384 ? -20.587 -44.295 3.864 1.00 43.26 ? 384 ASN A CG 1 ATOM 2995 O OD1 . ASN A 1 384 ? -21.149 -43.199 3.715 1.00 45.77 ? 384 ASN A OD1 1 ATOM 2996 N ND2 . ASN A 1 384 ? -20.141 -44.721 5.062 1.00 48.15 ? 384 ASN A ND2 1 ATOM 2997 N N . TYR A 1 385 ? -19.802 -46.346 -0.030 1.00 35.23 ? 385 TYR A N 1 ATOM 2998 C CA . TYR A 1 385 ? -18.881 -46.748 -1.050 1.00 34.72 ? 385 TYR A CA 1 ATOM 2999 C C . TYR A 1 385 ? -19.356 -46.412 -2.482 1.00 33.39 ? 385 TYR A C 1 ATOM 3000 O O . TYR A 1 385 ? -18.532 -46.070 -3.326 1.00 33.17 ? 385 TYR A O 1 ATOM 3001 C CB . TYR A 1 385 ? -18.571 -48.218 -0.932 1.00 34.58 ? 385 TYR A CB 1 ATOM 3002 C CG . TYR A 1 385 ? -17.668 -48.557 0.229 1.00 37.22 ? 385 TYR A CG 1 ATOM 3003 C CD1 . TYR A 1 385 ? -16.296 -48.355 0.148 1.00 37.91 ? 385 TYR A CD1 1 ATOM 3004 C CD2 . TYR A 1 385 ? -18.195 -49.105 1.399 1.00 40.14 ? 385 TYR A CD2 1 ATOM 3005 C CE1 . TYR A 1 385 ? -15.464 -48.670 1.203 1.00 39.25 ? 385 TYR A CE1 1 ATOM 3006 C CE2 . TYR A 1 385 ? -17.367 -49.449 2.460 1.00 42.60 ? 385 TYR A CE2 1 ATOM 3007 C CZ . TYR A 1 385 ? -16.010 -49.223 2.347 1.00 42.24 ? 385 TYR A CZ 1 ATOM 3008 O OH . TYR A 1 385 ? -15.221 -49.552 3.390 1.00 45.53 ? 385 TYR A OH 1 ATOM 3009 N N . ARG A 1 386 ? -20.665 -46.536 -2.739 1.00 31.74 ? 386 ARG A N 1 ATOM 3010 C CA . ARG A 1 386 ? -21.273 -46.156 -4.037 1.00 30.54 ? 386 ARG A CA 1 ATOM 3011 C C . ARG A 1 386 ? -21.008 -44.660 -4.353 1.00 29.40 ? 386 ARG A C 1 ATOM 3012 O O . ARG A 1 386 ? -20.551 -44.314 -5.430 1.00 29.97 ? 386 ARG A O 1 ATOM 3013 C CB . ARG A 1 386 ? -22.782 -46.447 -4.004 1.00 29.31 ? 386 ARG A CB 1 ATOM 3014 C CG . ARG A 1 386 ? -23.533 -46.166 -5.337 1.00 29.18 ? 386 ARG A CG 1 ATOM 3015 C CD . ARG A 1 386 ? -25.050 -46.101 -5.152 1.00 25.12 ? 386 ARG A CD 1 ATOM 3016 N NE . ARG A 1 386 ? -25.475 -44.853 -4.530 1.00 25.68 ? 386 ARG A NE 1 ATOM 3017 C CZ . ARG A 1 386 ? -26.624 -44.677 -3.875 1.00 28.40 ? 386 ARG A CZ 1 ATOM 3018 N NH1 . ARG A 1 386 ? -27.486 -45.679 -3.779 1.00 30.31 ? 386 ARG A NH1 1 ATOM 3019 N NH2 . ARG A 1 386 ? -26.926 -43.500 -3.324 1.00 22.09 ? 386 ARG A NH2 1 ATOM 3020 N N . GLU A 1 387 ? -21.243 -43.781 -3.392 1.00 28.93 ? 387 GLU A N 1 ATOM 3021 C CA . GLU A 1 387 ? -20.934 -42.359 -3.578 1.00 30.00 ? 387 GLU A CA 1 ATOM 3022 C C . GLU A 1 387 ? -19.456 -42.092 -3.783 1.00 29.11 ? 387 GLU A C 1 ATOM 3023 O O . GLU A 1 387 ? -19.059 -41.266 -4.658 1.00 27.03 ? 387 GLU A O 1 ATOM 3024 C CB . GLU A 1 387 ? -21.492 -41.532 -2.443 1.00 29.88 ? 387 GLU A CB 1 ATOM 3025 C CG . GLU A 1 387 ? -22.916 -41.879 -2.302 1.00 36.90 ? 387 GLU A CG 1 ATOM 3026 C CD . GLU A 1 387 ? -23.728 -40.821 -1.616 1.00 45.89 ? 387 GLU A CD 1 ATOM 3027 O OE1 . GLU A 1 387 ? -24.970 -40.811 -1.807 1.00 51.45 ? 387 GLU A OE1 1 ATOM 3028 O OE2 . GLU A 1 387 ? -23.137 -40.003 -0.891 1.00 49.55 ? 387 GLU A OE2 1 ATOM 3029 N N . ALA A 1 388 ? -18.634 -42.851 -3.050 1.00 28.00 ? 388 ALA A N 1 ATOM 3030 C CA . ALA A 1 388 ? -17.201 -42.590 -3.086 1.00 26.51 ? 388 ALA A CA 1 ATOM 3031 C C . ALA A 1 388 ? -16.648 -42.916 -4.452 1.00 26.08 ? 388 ALA A C 1 ATOM 3032 O O . ALA A 1 388 ? -15.808 -42.165 -4.951 1.00 25.61 ? 388 ALA A O 1 ATOM 3033 C CB . ALA A 1 388 ? -16.438 -43.375 -2.011 1.00 26.45 ? 388 ALA A CB 1 ATOM 3034 N N . LEU A 1 389 ? -17.093 -44.020 -5.063 1.00 25.10 ? 389 LEU A N 1 ATOM 3035 C CA . LEU A 1 389 ? -16.546 -44.392 -6.378 1.00 24.21 ? 389 LEU A CA 1 ATOM 3036 C C . LEU A 1 389 ? -16.923 -43.361 -7.453 1.00 24.10 ? 389 LEU A C 1 ATOM 3037 O O . LEU A 1 389 ? -16.130 -43.036 -8.366 1.00 25.11 ? 389 LEU A O 1 ATOM 3038 C CB . LEU A 1 389 ? -16.959 -45.818 -6.808 1.00 24.38 ? 389 LEU A CB 1 ATOM 3039 C CG . LEU A 1 389 ? -16.139 -46.340 -8.005 1.00 23.23 ? 389 LEU A CG 1 ATOM 3040 C CD1 . LEU A 1 389 ? -14.638 -46.345 -7.709 1.00 25.81 ? 389 LEU A CD1 1 ATOM 3041 C CD2 . LEU A 1 389 ? -16.608 -47.715 -8.456 1.00 25.58 ? 389 LEU A CD2 1 ATOM 3042 N N . GLY A 1 390 ? -18.118 -42.830 -7.355 1.00 23.84 ? 390 GLY A N 1 ATOM 3043 C CA . GLY A 1 390 ? -18.492 -41.807 -8.301 1.00 24.63 ? 390 GLY A CA 1 ATOM 3044 C C . GLY A 1 390 ? -17.686 -40.540 -8.152 1.00 24.00 ? 390 GLY A C 1 ATOM 3045 O O . GLY A 1 390 ? -17.266 -39.931 -9.125 1.00 22.99 ? 390 GLY A O 1 ATOM 3046 N N . ASP A 1 391 ? -17.452 -40.127 -6.910 1.00 24.96 ? 391 ASP A N 1 ATOM 3047 C CA . ASP A 1 391 ? -16.629 -38.938 -6.695 1.00 24.57 ? 391 ASP A CA 1 ATOM 3048 C C . ASP A 1 391 ? -15.201 -39.153 -7.138 1.00 24.21 ? 391 ASP A C 1 ATOM 3049 O O . ASP A 1 391 ? -14.609 -38.258 -7.766 1.00 24.79 ? 391 ASP A O 1 ATOM 3050 C CB . ASP A 1 391 ? -16.718 -38.465 -5.257 1.00 24.77 ? 391 ASP A CB 1 ATOM 3051 C CG . ASP A 1 391 ? -18.071 -37.846 -4.954 1.00 28.45 ? 391 ASP A CG 1 ATOM 3052 O OD1 . ASP A 1 391 ? -18.595 -37.008 -5.754 1.00 30.42 ? 391 ASP A OD1 1 ATOM 3053 O OD2 . ASP A 1 391 ? -18.629 -38.172 -3.901 1.00 31.79 ? 391 ASP A OD2 1 ATOM 3054 N N . VAL A 1 392 ? -14.631 -40.316 -6.841 1.00 23.37 ? 392 VAL A N 1 ATOM 3055 C CA . VAL A 1 392 ? -13.278 -40.631 -7.326 1.00 23.08 ? 392 VAL A CA 1 ATOM 3056 C C . VAL A 1 392 ? -13.214 -40.375 -8.837 1.00 23.06 ? 392 VAL A C 1 ATOM 3057 O O . VAL A 1 392 ? -12.371 -39.652 -9.342 1.00 23.31 ? 392 VAL A O 1 ATOM 3058 C CB . VAL A 1 392 ? -12.922 -42.144 -7.003 1.00 24.10 ? 392 VAL A CB 1 ATOM 3059 C CG1 . VAL A 1 392 ? -11.712 -42.635 -7.817 1.00 23.07 ? 392 VAL A CG1 1 ATOM 3060 C CG2 . VAL A 1 392 ? -12.657 -42.349 -5.533 1.00 24.25 ? 392 VAL A CG2 1 ATOM 3061 N N . VAL A 1 393 ? -14.136 -41.006 -9.569 1.00 23.68 ? 393 VAL A N 1 ATOM 3062 C CA . VAL A 1 393 ? -14.116 -40.954 -11.022 1.00 21.68 ? 393 VAL A CA 1 ATOM 3063 C C . VAL A 1 393 ? -14.385 -39.522 -11.523 1.00 21.24 ? 393 VAL A C 1 ATOM 3064 O O . VAL A 1 393 ? -13.752 -39.030 -12.479 1.00 21.94 ? 393 VAL A O 1 ATOM 3065 C CB . VAL A 1 393 ? -15.120 -41.991 -11.654 1.00 21.09 ? 393 VAL A CB 1 ATOM 3066 C CG1 . VAL A 1 393 ? -15.244 -41.736 -13.184 1.00 15.19 ? 393 VAL A CG1 1 ATOM 3067 C CG2 . VAL A 1 393 ? -14.638 -43.453 -11.385 1.00 19.75 ? 393 VAL A CG2 1 ATOM 3068 N N . GLY A 1 394 ? -15.318 -38.834 -10.908 1.00 20.59 ? 394 GLY A N 1 ATOM 3069 C CA . GLY A 1 394 ? -15.567 -37.456 -11.372 1.00 20.60 ? 394 GLY A CA 1 ATOM 3070 C C . GLY A 1 394 ? -14.435 -36.492 -11.019 1.00 20.98 ? 394 GLY A C 1 ATOM 3071 O O . GLY A 1 394 ? -14.028 -35.640 -11.845 1.00 19.59 ? 394 GLY A O 1 ATOM 3072 N N . ASP A 1 395 ? -13.934 -36.568 -9.777 1.00 20.48 ? 395 ASP A N 1 ATOM 3073 C CA . ASP A 1 395 ? -12.875 -35.596 -9.355 1.00 19.94 ? 395 ASP A CA 1 ATOM 3074 C C . ASP A 1 395 ? -11.604 -35.768 -10.190 1.00 20.35 ? 395 ASP A C 1 ATOM 3075 O O . ASP A 1 395 ? -11.007 -34.824 -10.704 1.00 20.96 ? 395 ASP A O 1 ATOM 3076 C CB . ASP A 1 395 ? -12.573 -35.783 -7.886 1.00 20.35 ? 395 ASP A CB 1 ATOM 3077 C CG . ASP A 1 395 ? -13.744 -35.392 -7.009 1.00 21.60 ? 395 ASP A CG 1 ATOM 3078 O OD1 . ASP A 1 395 ? -13.715 -35.775 -5.825 1.00 20.41 ? 395 ASP A OD1 1 ATOM 3079 O OD2 . ASP A 1 395 ? -14.704 -34.720 -7.505 1.00 20.53 ? 395 ASP A OD2 1 ATOM 3080 N N . TYR A 1 396 ? -11.192 -37.004 -10.368 1.00 21.93 ? 396 TYR A N 1 ATOM 3081 C CA . TYR A 1 396 ? -9.987 -37.308 -11.168 1.00 21.52 ? 396 TYR A CA 1 ATOM 3082 C C . TYR A 1 396 ? -10.147 -36.935 -12.618 1.00 21.03 ? 396 TYR A C 1 ATOM 3083 O O . TYR A 1 396 ? -9.272 -36.355 -13.218 1.00 20.56 ? 396 TYR A O 1 ATOM 3084 C CB . TYR A 1 396 ? -9.740 -38.814 -11.111 1.00 21.62 ? 396 TYR A CB 1 ATOM 3085 C CG . TYR A 1 396 ? -8.593 -39.325 -11.928 1.00 22.75 ? 396 TYR A CG 1 ATOM 3086 C CD1 . TYR A 1 396 ? -7.316 -38.781 -11.803 1.00 24.05 ? 396 TYR A CD1 1 ATOM 3087 C CD2 . TYR A 1 396 ? -8.754 -40.430 -12.745 1.00 23.28 ? 396 TYR A CD2 1 ATOM 3088 C CE1 . TYR A 1 396 ? -6.235 -39.296 -12.533 1.00 25.64 ? 396 TYR A CE1 1 ATOM 3089 C CE2 . TYR A 1 396 ? -7.687 -40.952 -13.481 1.00 22.25 ? 396 TYR A CE2 1 ATOM 3090 C CZ . TYR A 1 396 ? -6.445 -40.386 -13.366 1.00 25.09 ? 396 TYR A CZ 1 ATOM 3091 O OH . TYR A 1 396 ? -5.413 -40.879 -14.088 1.00 26.19 ? 396 TYR A OH 1 ATOM 3092 N N . ASN A 1 397 ? -11.255 -37.357 -13.210 1.00 20.16 ? 397 ASN A N 1 ATOM 3093 C CA . ASN A 1 397 ? -11.403 -37.211 -14.655 1.00 20.97 ? 397 ASN A CA 1 ATOM 3094 C C . ASN A 1 397 ? -11.865 -35.856 -15.132 1.00 19.26 ? 397 ASN A C 1 ATOM 3095 O O . ASN A 1 397 ? -11.532 -35.443 -16.243 1.00 20.82 ? 397 ASN A O 1 ATOM 3096 C CB . ASN A 1 397 ? -12.331 -38.306 -15.207 1.00 19.80 ? 397 ASN A CB 1 ATOM 3097 C CG . ASN A 1 397 ? -11.623 -39.572 -15.342 1.00 22.04 ? 397 ASN A CG 1 ATOM 3098 O OD1 . ASN A 1 397 ? -10.753 -39.720 -16.218 1.00 18.28 ? 397 ASN A OD1 1 ATOM 3099 N ND2 . ASN A 1 397 ? -11.898 -40.491 -14.423 1.00 19.76 ? 397 ASN A ND2 1 ATOM 3100 N N . PHE A 1 398 ? -12.667 -35.176 -14.336 1.00 18.14 ? 398 PHE A N 1 ATOM 3101 C CA . PHE A 1 398 ? -13.247 -33.929 -14.810 1.00 17.89 ? 398 PHE A CA 1 ATOM 3102 C C . PHE A 1 398 ? -13.006 -32.683 -13.911 1.00 18.95 ? 398 PHE A C 1 ATOM 3103 O O . PHE A 1 398 ? -12.577 -31.582 -14.401 1.00 15.81 ? 398 PHE A O 1 ATOM 3104 C CB . PHE A 1 398 ? -14.771 -34.149 -15.030 1.00 17.99 ? 398 PHE A CB 1 ATOM 3105 C CG . PHE A 1 398 ? -15.065 -35.173 -16.111 1.00 18.68 ? 398 PHE A CG 1 ATOM 3106 C CD1 . PHE A 1 398 ? -15.373 -36.514 -15.770 1.00 20.08 ? 398 PHE A CD1 1 ATOM 3107 C CD2 . PHE A 1 398 ? -14.948 -34.826 -17.447 1.00 20.06 ? 398 PHE A CD2 1 ATOM 3108 C CE1 . PHE A 1 398 ? -15.569 -37.510 -16.728 1.00 22.24 ? 398 PHE A CE1 1 ATOM 3109 C CE2 . PHE A 1 398 ? -15.173 -35.813 -18.451 1.00 22.54 ? 398 PHE A CE2 1 ATOM 3110 C CZ . PHE A 1 398 ? -15.470 -37.163 -18.086 1.00 22.35 ? 398 PHE A CZ 1 ATOM 3111 N N . ILE A 1 399 ? -13.407 -32.819 -12.648 1.00 16.45 ? 399 ILE A N 1 ATOM 3112 C CA . ILE A 1 399 ? -13.514 -31.645 -11.789 1.00 19.26 ? 399 ILE A CA 1 ATOM 3113 C C . ILE A 1 399 ? -12.161 -31.028 -11.427 1.00 19.13 ? 399 ILE A C 1 ATOM 3114 O O . ILE A 1 399 ? -11.945 -29.846 -11.687 1.00 21.66 ? 399 ILE A O 1 ATOM 3115 C CB . ILE A 1 399 ? -14.307 -31.946 -10.478 1.00 18.84 ? 399 ILE A CB 1 ATOM 3116 C CG1 . ILE A 1 399 ? -15.754 -32.339 -10.852 1.00 18.78 ? 399 ILE A CG1 1 ATOM 3117 C CG2 . ILE A 1 399 ? -14.219 -30.747 -9.542 1.00 20.24 ? 399 ILE A CG2 1 ATOM 3118 C CD1 . ILE A 1 399 ? -16.713 -32.349 -9.694 1.00 20.80 ? 399 ILE A CD1 1 ATOM 3119 N N . CYS A 1 400 ? -11.246 -31.793 -10.835 1.00 19.44 ? 400 CYS A N 1 ATOM 3120 C CA . CYS A 1 400 ? -9.956 -31.220 -10.500 1.00 18.39 ? 400 CYS A CA 1 ATOM 3121 C C . CYS A 1 400 ? -9.177 -30.779 -11.755 1.00 18.67 ? 400 CYS A C 1 ATOM 3122 O O . CYS A 1 400 ? -8.487 -29.803 -11.702 1.00 16.59 ? 400 CYS A O 1 ATOM 3123 C CB . CYS A 1 400 ? -9.123 -32.240 -9.747 1.00 20.23 ? 400 CYS A CB 1 ATOM 3124 S SG . CYS A 1 400 ? -9.969 -32.759 -8.235 1.00 24.21 ? 400 CYS A SG 1 ATOM 3125 N N . PRO A 1 401 ? -9.215 -31.554 -12.874 1.00 17.98 ? 401 PRO A N 1 ATOM 3126 C CA . PRO A 1 401 ? -8.456 -31.017 -14.002 1.00 18.01 ? 401 PRO A CA 1 ATOM 3127 C C . PRO A 1 401 ? -9.087 -29.673 -14.496 1.00 18.80 ? 401 PRO A C 1 ATOM 3128 O O . PRO A 1 401 ? -8.346 -28.783 -14.913 1.00 20.90 ? 401 PRO A O 1 ATOM 3129 C CB . PRO A 1 401 ? -8.617 -32.099 -15.068 1.00 18.01 ? 401 PRO A CB 1 ATOM 3130 C CG . PRO A 1 401 ? -8.772 -33.374 -14.270 1.00 18.67 ? 401 PRO A CG 1 ATOM 3131 C CD . PRO A 1 401 ? -9.637 -32.948 -13.106 1.00 17.87 ? 401 PRO A CD 1 ATOM 3132 N N . ALA A 1 402 ? -10.423 -29.521 -14.471 1.00 17.99 ? 402 ALA A N 1 ATOM 3133 C CA . ALA A 1 402 ? -11.054 -28.233 -14.856 1.00 17.75 ? 402 ALA A CA 1 ATOM 3134 C C . ALA A 1 402 ? -10.608 -27.122 -13.863 1.00 18.45 ? 402 ALA A C 1 ATOM 3135 O O . ALA A 1 402 ? -10.242 -26.000 -14.266 1.00 17.72 ? 402 ALA A O 1 ATOM 3136 C CB . ALA A 1 402 ? -12.582 -28.341 -14.863 1.00 15.55 ? 402 ALA A CB 1 ATOM 3137 N N . LEU A 1 403 ? -10.642 -27.413 -12.572 1.00 18.74 ? 403 LEU A N 1 ATOM 3138 C CA . LEU A 1 403 ? -10.202 -26.376 -11.626 1.00 20.06 ? 403 LEU A CA 1 ATOM 3139 C C . LEU A 1 403 ? -8.740 -26.017 -11.854 1.00 19.70 ? 403 LEU A C 1 ATOM 3140 O O . LEU A 1 403 ? -8.361 -24.864 -11.843 1.00 20.66 ? 403 LEU A O 1 ATOM 3141 C CB . LEU A 1 403 ? -10.437 -26.835 -10.199 1.00 20.46 ? 403 LEU A CB 1 ATOM 3142 C CG . LEU A 1 403 ? -11.907 -26.887 -9.806 1.00 21.36 ? 403 LEU A CG 1 ATOM 3143 C CD1 . LEU A 1 403 ? -12.118 -27.732 -8.535 1.00 19.65 ? 403 LEU A CD1 1 ATOM 3144 C CD2 . LEU A 1 403 ? -12.385 -25.477 -9.586 1.00 21.27 ? 403 LEU A CD2 1 ATOM 3145 N N . GLU A 1 404 ? -7.898 -26.995 -12.100 1.00 20.86 ? 404 GLU A N 1 ATOM 3146 C CA . GLU A 1 404 ? -6.478 -26.687 -12.198 1.00 22.60 ? 404 GLU A CA 1 ATOM 3147 C C . GLU A 1 404 ? -6.214 -25.899 -13.500 1.00 22.27 ? 404 GLU A C 1 ATOM 3148 O O . GLU A 1 404 ? -5.386 -24.987 -13.527 1.00 22.82 ? 404 GLU A O 1 ATOM 3149 C CB . GLU A 1 404 ? -5.665 -27.983 -12.129 1.00 25.21 ? 404 GLU A CB 1 ATOM 3150 C CG . GLU A 1 404 ? -4.198 -27.786 -12.351 1.00 31.52 ? 404 GLU A CG 1 ATOM 3151 C CD . GLU A 1 404 ? -3.487 -27.127 -11.099 1.00 38.84 ? 404 GLU A CD 1 ATOM 3152 O OE1 . GLU A 1 404 ? -4.129 -26.810 -10.060 1.00 38.58 ? 404 GLU A OE1 1 ATOM 3153 O OE2 . GLU A 1 404 ? -2.250 -26.984 -11.162 1.00 45.49 ? 404 GLU A OE2 1 ATOM 3154 N N . PHE A 1 405 ? -6.938 -26.226 -14.579 1.00 19.76 ? 405 PHE A N 1 ATOM 3155 C CA . PHE A 1 405 ? -6.823 -25.465 -15.836 1.00 18.14 ? 405 PHE A CA 1 ATOM 3156 C C . PHE A 1 405 ? -7.176 -24.011 -15.546 1.00 16.84 ? 405 PHE A C 1 ATOM 3157 O O . PHE A 1 405 ? -6.564 -23.099 -16.053 1.00 17.49 ? 405 PHE A O 1 ATOM 3158 C CB . PHE A 1 405 ? -7.799 -26.017 -16.938 1.00 15.65 ? 405 PHE A CB 1 ATOM 3159 C CG . PHE A 1 405 ? -7.772 -25.208 -18.217 1.00 19.77 ? 405 PHE A CG 1 ATOM 3160 C CD1 . PHE A 1 405 ? -6.811 -25.451 -19.204 1.00 19.85 ? 405 PHE A CD1 1 ATOM 3161 C CD2 . PHE A 1 405 ? -8.662 -24.151 -18.409 1.00 20.06 ? 405 PHE A CD2 1 ATOM 3162 C CE1 . PHE A 1 405 ? -6.784 -24.653 -20.371 1.00 21.90 ? 405 PHE A CE1 1 ATOM 3163 C CE2 . PHE A 1 405 ? -8.643 -23.382 -19.572 1.00 21.07 ? 405 PHE A CE2 1 ATOM 3164 C CZ . PHE A 1 405 ? -7.700 -23.634 -20.542 1.00 18.53 ? 405 PHE A CZ 1 ATOM 3165 N N . THR A 1 406 ? -8.258 -23.786 -14.805 1.00 17.23 ? 406 THR A N 1 ATOM 3166 C CA . THR A 1 406 ? -8.801 -22.449 -14.656 1.00 18.09 ? 406 THR A CA 1 ATOM 3167 C C . THR A 1 406 ? -7.793 -21.650 -13.817 1.00 18.80 ? 406 THR A C 1 ATOM 3168 O O . THR A 1 406 ? -7.490 -20.481 -14.086 1.00 20.60 ? 406 THR A O 1 ATOM 3169 C CB . THR A 1 406 ? -10.203 -22.521 -13.957 1.00 18.36 ? 406 THR A CB 1 ATOM 3170 O OG1 . THR A 1 406 ? -11.094 -23.398 -14.685 1.00 20.66 ? 406 THR A OG1 1 ATOM 3171 C CG2 . THR A 1 406 ? -10.876 -21.094 -13.838 1.00 19.71 ? 406 THR A CG2 1 ATOM 3172 N N . LYS A 1 407 ? -7.274 -22.293 -12.781 1.00 20.03 ? 407 LYS A N 1 ATOM 3173 C CA . LYS A 1 407 ? -6.284 -21.698 -11.907 1.00 22.86 ? 407 LYS A CA 1 ATOM 3174 C C . LYS A 1 407 ? -5.075 -21.246 -12.723 1.00 22.91 ? 407 LYS A C 1 ATOM 3175 O O . LYS A 1 407 ? -4.722 -20.063 -12.716 1.00 23.38 ? 407 LYS A O 1 ATOM 3176 C CB . LYS A 1 407 ? -5.933 -22.746 -10.861 1.00 22.68 ? 407 LYS A CB 1 ATOM 3177 C CG . LYS A 1 407 ? -5.165 -22.230 -9.751 1.00 31.75 ? 407 LYS A CG 1 ATOM 3178 C CD . LYS A 1 407 ? -5.032 -23.349 -8.679 1.00 39.25 ? 407 LYS A CD 1 ATOM 3179 C CE . LYS A 1 407 ? -6.412 -24.034 -8.489 1.00 41.17 ? 407 LYS A CE 1 ATOM 3180 N NZ . LYS A 1 407 ? -6.387 -24.910 -7.264 1.00 44.74 ? 407 LYS A NZ 1 ATOM 3181 N N . LYS A 1 408 ? -4.503 -22.159 -13.515 1.00 22.43 ? 408 LYS A N 1 ATOM 3182 C CA . LYS A 1 408 ? -3.311 -21.846 -14.274 1.00 23.76 ? 408 LYS A CA 1 ATOM 3183 C C . LYS A 1 408 ? -3.533 -20.825 -15.399 1.00 23.54 ? 408 LYS A C 1 ATOM 3184 O O . LYS A 1 408 ? -2.649 -20.021 -15.728 1.00 24.05 ? 408 LYS A O 1 ATOM 3185 C CB . LYS A 1 408 ? -2.710 -23.123 -14.869 1.00 22.90 ? 408 LYS A CB 1 ATOM 3186 C CG . LYS A 1 408 ? -2.268 -24.158 -13.845 1.00 27.59 ? 408 LYS A CG 1 ATOM 3187 C CD . LYS A 1 408 ? -0.957 -23.742 -13.189 1.00 36.37 ? 408 LYS A CD 1 ATOM 3188 C CE . LYS A 1 408 ? -0.209 -24.945 -12.535 1.00 39.43 ? 408 LYS A CE 1 ATOM 3189 N NZ . LYS A 1 408 ? 0.895 -24.369 -11.661 1.00 42.31 ? 408 LYS A NZ 1 ATOM 3190 N N . PHE A 1 409 ? -4.693 -20.876 -16.035 1.00 23.62 ? 409 PHE A N 1 ATOM 3191 C CA . PHE A 1 409 ? -4.995 -19.931 -17.093 1.00 22.82 ? 409 PHE A CA 1 ATOM 3192 C C . PHE A 1 409 ? -5.147 -18.524 -16.504 1.00 23.77 ? 409 PHE A C 1 ATOM 3193 O O . PHE A 1 409 ? -4.650 -17.517 -17.063 1.00 23.56 ? 409 PHE A O 1 ATOM 3194 C CB . PHE A 1 409 ? -6.281 -20.369 -17.816 1.00 22.69 ? 409 PHE A CB 1 ATOM 3195 C CG . PHE A 1 409 ? -6.588 -19.565 -19.065 1.00 22.14 ? 409 PHE A CG 1 ATOM 3196 C CD1 . PHE A 1 409 ? -6.192 -20.010 -20.307 1.00 22.11 ? 409 PHE A CD1 1 ATOM 3197 C CD2 . PHE A 1 409 ? -7.261 -18.371 -18.977 1.00 21.21 ? 409 PHE A CD2 1 ATOM 3198 C CE1 . PHE A 1 409 ? -6.469 -19.232 -21.456 1.00 23.50 ? 409 PHE A CE1 1 ATOM 3199 C CE2 . PHE A 1 409 ? -7.573 -17.604 -20.123 1.00 20.16 ? 409 PHE A CE2 1 ATOM 3200 C CZ . PHE A 1 409 ? -7.115 -18.037 -21.359 1.00 19.23 ? 409 PHE A CZ 1 ATOM 3201 N N . SER A 1 410 ? -5.837 -18.431 -15.369 1.00 24.67 ? 410 SER A N 1 ATOM 3202 C CA . SER A 1 410 ? -6.137 -17.129 -14.809 1.00 24.64 ? 410 SER A CA 1 ATOM 3203 C C . SER A 1 410 ? -4.887 -16.433 -14.247 1.00 26.02 ? 410 SER A C 1 ATOM 3204 O O . SER A 1 410 ? -4.815 -15.200 -14.208 1.00 26.35 ? 410 SER A O 1 ATOM 3205 C CB . SER A 1 410 ? -7.225 -17.270 -13.744 1.00 25.21 ? 410 SER A CB 1 ATOM 3206 O OG . SER A 1 410 ? -6.649 -17.864 -12.589 1.00 26.70 ? 410 SER A OG 1 ATOM 3207 N N . GLU A 1 411 ? -3.869 -17.212 -13.873 1.00 27.70 ? 411 GLU A N 1 ATOM 3208 C CA . GLU A 1 411 ? -2.621 -16.642 -13.323 1.00 28.28 ? 411 GLU A CA 1 ATOM 3209 C C . GLU A 1 411 ? -1.891 -15.766 -14.309 1.00 29.16 ? 411 GLU A C 1 ATOM 3210 O O . GLU A 1 411 ? -0.970 -15.030 -13.924 1.00 28.84 ? 411 GLU A O 1 ATOM 3211 C CB . GLU A 1 411 ? -1.669 -17.740 -12.890 1.00 28.44 ? 411 GLU A CB 1 ATOM 3212 C CG . GLU A 1 411 ? -1.906 -18.108 -11.440 1.00 32.94 ? 411 GLU A CG 1 ATOM 3213 C CD . GLU A 1 411 ? -1.475 -19.517 -11.127 1.00 39.60 ? 411 GLU A CD 1 ATOM 3214 O OE1 . GLU A 1 411 ? -0.514 -20.018 -11.748 1.00 41.86 ? 411 GLU A OE1 1 ATOM 3215 O OE2 . GLU A 1 411 ? -2.102 -20.135 -10.253 1.00 45.84 ? 411 GLU A OE2 1 ATOM 3216 N N . TRP A 1 412 ? -2.273 -15.825 -15.579 1.00 28.01 ? 412 TRP A N 1 ATOM 3217 C CA . TRP A 1 412 ? -1.594 -15.004 -16.548 1.00 27.50 ? 412 TRP A CA 1 ATOM 3218 C C . TRP A 1 412 ? -2.406 -13.803 -16.820 1.00 27.28 ? 412 TRP A C 1 ATOM 3219 O O . TRP A 1 412 ? -2.169 -13.128 -17.770 1.00 28.09 ? 412 TRP A O 1 ATOM 3220 C CB . TRP A 1 412 ? -1.294 -15.777 -17.840 1.00 27.16 ? 412 TRP A CB 1 ATOM 3221 C CG . TRP A 1 412 ? -0.186 -16.725 -17.583 1.00 29.46 ? 412 TRP A CG 1 ATOM 3222 C CD1 . TRP A 1 412 ? -0.279 -17.984 -17.077 1.00 30.06 ? 412 TRP A CD1 1 ATOM 3223 C CD2 . TRP A 1 412 ? 1.216 -16.452 -17.740 1.00 30.34 ? 412 TRP A CD2 1 ATOM 3224 N NE1 . TRP A 1 412 ? 0.988 -18.526 -16.911 1.00 30.45 ? 412 TRP A NE1 1 ATOM 3225 C CE2 . TRP A 1 412 ? 1.918 -17.603 -17.329 1.00 31.05 ? 412 TRP A CE2 1 ATOM 3226 C CE3 . TRP A 1 412 ? 1.949 -15.339 -18.225 1.00 34.06 ? 412 TRP A CE3 1 ATOM 3227 C CZ2 . TRP A 1 412 ? 3.337 -17.682 -17.374 1.00 31.67 ? 412 TRP A CZ2 1 ATOM 3228 C CZ3 . TRP A 1 412 ? 3.363 -15.426 -18.277 1.00 31.21 ? 412 TRP A CZ3 1 ATOM 3229 C CH2 . TRP A 1 412 ? 4.026 -16.580 -17.839 1.00 30.68 ? 412 TRP A CH2 1 ATOM 3230 N N . GLY A 1 413 ? -3.396 -13.511 -16.002 1.00 27.88 ? 413 GLY A N 1 ATOM 3231 C CA . GLY A 1 413 ? -3.973 -12.186 -16.098 1.00 27.34 ? 413 GLY A CA 1 ATOM 3232 C C . GLY A 1 413 ? -5.313 -12.064 -16.774 1.00 28.62 ? 413 GLY A C 1 ATOM 3233 O O . GLY A 1 413 ? -5.807 -10.970 -16.945 1.00 30.32 ? 413 GLY A O 1 ATOM 3234 N N . ASN A 1 414 ? -5.932 -13.170 -17.164 1.00 28.16 ? 414 ASN A N 1 ATOM 3235 C CA . ASN A 1 414 ? -7.221 -13.068 -17.811 1.00 27.05 ? 414 ASN A CA 1 ATOM 3236 C C . ASN A 1 414 ? -8.334 -13.386 -16.862 1.00 26.38 ? 414 ASN A C 1 ATOM 3237 O O . ASN A 1 414 ? -8.175 -14.194 -15.948 1.00 25.87 ? 414 ASN A O 1 ATOM 3238 C CB . ASN A 1 414 ? -7.252 -14.020 -18.982 1.00 27.99 ? 414 ASN A CB 1 ATOM 3239 C CG . ASN A 1 414 ? -6.492 -13.460 -20.183 1.00 28.29 ? 414 ASN A CG 1 ATOM 3240 O OD1 . ASN A 1 414 ? -5.430 -13.966 -20.494 1.00 27.58 ? 414 ASN A OD1 1 ATOM 3241 N ND2 . ASN A 1 414 ? -7.037 -12.384 -20.850 1.00 29.03 ? 414 ASN A ND2 1 ATOM 3242 N N . ASN A 1 415 ? -9.442 -12.703 -17.049 1.00 26.08 ? 415 ASN A N 1 ATOM 3243 C CA . ASN A 1 415 ? -10.677 -13.052 -16.392 1.00 26.12 ? 415 ASN A CA 1 ATOM 3244 C C . ASN A 1 415 ? -11.167 -14.470 -16.737 1.00 26.25 ? 415 ASN A C 1 ATOM 3245 O O . ASN A 1 415 ? -11.239 -14.843 -17.919 1.00 27.19 ? 415 ASN A O 1 ATOM 3246 C CB . ASN A 1 415 ? -11.743 -12.049 -16.839 1.00 26.34 ? 415 ASN A CB 1 ATOM 3247 C CG . ASN A 1 415 ? -11.659 -10.738 -16.067 1.00 29.23 ? 415 ASN A CG 1 ATOM 3248 O OD1 . ASN A 1 415 ? -10.862 -10.608 -15.112 1.00 29.41 ? 415 ASN A OD1 1 ATOM 3249 N ND2 . ASN A 1 415 ? -12.496 -9.780 -16.452 1.00 26.99 ? 415 ASN A ND2 1 ATOM 3250 N N . ALA A 1 416 ? -11.530 -15.237 -15.712 1.00 25.06 ? 416 ALA A N 1 ATOM 3251 C CA . ALA A 1 416 ? -12.030 -16.577 -15.888 1.00 23.26 ? 416 ALA A CA 1 ATOM 3252 C C . ALA A 1 416 ? -13.209 -16.629 -14.941 1.00 23.15 ? 416 ALA A C 1 ATOM 3253 O O . ALA A 1 416 ? -13.164 -15.974 -13.864 1.00 23.50 ? 416 ALA A O 1 ATOM 3254 C CB . ALA A 1 416 ? -10.946 -17.599 -15.460 1.00 23.16 ? 416 ALA A CB 1 ATOM 3255 N N . PHE A 1 417 ? -14.252 -17.358 -15.327 1.00 20.12 ? 417 PHE A N 1 ATOM 3256 C CA . PHE A 1 417 ? -15.466 -17.549 -14.519 1.00 20.21 ? 417 PHE A CA 1 ATOM 3257 C C . PHE A 1 417 ? -15.724 -19.033 -14.333 1.00 20.33 ? 417 PHE A C 1 ATOM 3258 O O . PHE A 1 417 ? -15.628 -19.794 -15.294 1.00 20.96 ? 417 PHE A O 1 ATOM 3259 C CB . PHE A 1 417 ? -16.662 -16.863 -15.220 1.00 18.69 ? 417 PHE A CB 1 ATOM 3260 C CG . PHE A 1 417 ? -16.407 -15.404 -15.491 1.00 19.73 ? 417 PHE A CG 1 ATOM 3261 C CD1 . PHE A 1 417 ? -15.723 -15.008 -16.624 1.00 17.67 ? 417 PHE A CD1 1 ATOM 3262 C CD2 . PHE A 1 417 ? -16.787 -14.426 -14.551 1.00 19.47 ? 417 PHE A CD2 1 ATOM 3263 C CE1 . PHE A 1 417 ? -15.443 -13.608 -16.870 1.00 17.83 ? 417 PHE A CE1 1 ATOM 3264 C CE2 . PHE A 1 417 ? -16.514 -13.078 -14.763 1.00 21.00 ? 417 PHE A CE2 1 ATOM 3265 C CZ . PHE A 1 417 ? -15.830 -12.657 -15.919 1.00 15.45 ? 417 PHE A CZ 1 ATOM 3266 N N . PHE A 1 418 ? -16.043 -19.475 -13.121 1.00 19.87 ? 418 PHE A N 1 ATOM 3267 C CA . PHE A 1 418 ? -16.167 -20.935 -12.919 1.00 18.59 ? 418 PHE A CA 1 ATOM 3268 C C . PHE A 1 418 ? -17.533 -21.293 -12.371 1.00 19.18 ? 418 PHE A C 1 ATOM 3269 O O . PHE A 1 418 ? -18.056 -20.591 -11.436 1.00 17.32 ? 418 PHE A O 1 ATOM 3270 C CB . PHE A 1 418 ? -15.021 -21.452 -12.041 1.00 17.99 ? 418 PHE A CB 1 ATOM 3271 C CG . PHE A 1 418 ? -14.867 -22.929 -12.081 1.00 14.30 ? 418 PHE A CG 1 ATOM 3272 C CD1 . PHE A 1 418 ? -15.731 -23.729 -11.381 1.00 14.95 ? 418 PHE A CD1 1 ATOM 3273 C CD2 . PHE A 1 418 ? -13.885 -23.519 -12.855 1.00 16.52 ? 418 PHE A CD2 1 ATOM 3274 C CE1 . PHE A 1 418 ? -15.627 -25.124 -11.434 1.00 17.98 ? 418 PHE A CE1 1 ATOM 3275 C CE2 . PHE A 1 418 ? -13.793 -24.914 -12.938 1.00 16.30 ? 418 PHE A CE2 1 ATOM 3276 C CZ . PHE A 1 418 ? -14.632 -25.710 -12.210 1.00 15.23 ? 418 PHE A CZ 1 ATOM 3277 N N . TYR A 1 419 ? -18.189 -22.312 -12.957 1.00 18.62 ? 419 TYR A N 1 ATOM 3278 C CA . TYR A 1 419 ? -19.534 -22.667 -12.402 1.00 18.66 ? 419 TYR A CA 1 ATOM 3279 C C . TYR A 1 419 ? -19.558 -24.090 -11.908 1.00 19.49 ? 419 TYR A C 1 ATOM 3280 O O . TYR A 1 419 ? -18.800 -24.955 -12.371 1.00 18.73 ? 419 TYR A O 1 ATOM 3281 C CB . TYR A 1 419 ? -20.719 -22.504 -13.381 1.00 19.80 ? 419 TYR A CB 1 ATOM 3282 C CG . TYR A 1 419 ? -20.636 -23.477 -14.569 1.00 17.56 ? 419 TYR A CG 1 ATOM 3283 C CD1 . TYR A 1 419 ? -20.073 -23.081 -15.800 1.00 22.21 ? 419 TYR A CD1 1 ATOM 3284 C CD2 . TYR A 1 419 ? -21.100 -24.766 -14.460 1.00 19.60 ? 419 TYR A CD2 1 ATOM 3285 C CE1 . TYR A 1 419 ? -19.957 -23.976 -16.894 1.00 17.01 ? 419 TYR A CE1 1 ATOM 3286 C CE2 . TYR A 1 419 ? -21.045 -25.641 -15.535 1.00 21.74 ? 419 TYR A CE2 1 ATOM 3287 C CZ . TYR A 1 419 ? -20.444 -25.265 -16.740 1.00 20.21 ? 419 TYR A CZ 1 ATOM 3288 O OH . TYR A 1 419 ? -20.354 -26.207 -17.767 1.00 20.22 ? 419 TYR A OH 1 ATOM 3289 N N . TYR A 1 420 ? -20.464 -24.331 -10.965 1.00 20.14 ? 420 TYR A N 1 ATOM 3290 C CA . TYR A 1 420 ? -20.685 -25.670 -10.476 1.00 20.73 ? 420 TYR A CA 1 ATOM 3291 C C . TYR A 1 420 ? -22.161 -25.953 -10.672 1.00 21.24 ? 420 TYR A C 1 ATOM 3292 O O . TYR A 1 420 ? -23.003 -25.367 -9.992 1.00 21.49 ? 420 TYR A O 1 ATOM 3293 C CB . TYR A 1 420 ? -20.353 -25.726 -9.005 1.00 20.19 ? 420 TYR A CB 1 ATOM 3294 C CG . TYR A 1 420 ? -20.438 -27.088 -8.378 1.00 20.91 ? 420 TYR A CG 1 ATOM 3295 C CD1 . TYR A 1 420 ? -19.592 -28.110 -8.804 1.00 19.71 ? 420 TYR A CD1 1 ATOM 3296 C CD2 . TYR A 1 420 ? -21.318 -27.339 -7.319 1.00 18.99 ? 420 TYR A CD2 1 ATOM 3297 C CE1 . TYR A 1 420 ? -19.590 -29.337 -8.209 1.00 20.27 ? 420 TYR A CE1 1 ATOM 3298 C CE2 . TYR A 1 420 ? -21.324 -28.566 -6.707 1.00 23.57 ? 420 TYR A CE2 1 ATOM 3299 C CZ . TYR A 1 420 ? -20.453 -29.576 -7.174 1.00 24.35 ? 420 TYR A CZ 1 ATOM 3300 O OH . TYR A 1 420 ? -20.415 -30.843 -6.601 1.00 28.19 ? 420 TYR A OH 1 ATOM 3301 N N . PHE A 1 421 ? -22.471 -26.853 -11.597 1.00 21.10 ? 421 PHE A N 1 ATOM 3302 C CA . PHE A 1 421 ? -23.862 -27.053 -12.014 1.00 21.83 ? 421 PHE A CA 1 ATOM 3303 C C . PHE A 1 421 ? -24.486 -28.145 -11.164 1.00 21.25 ? 421 PHE A C 1 ATOM 3304 O O . PHE A 1 421 ? -24.044 -29.292 -11.159 1.00 20.39 ? 421 PHE A O 1 ATOM 3305 C CB . PHE A 1 421 ? -23.887 -27.426 -13.487 1.00 20.57 ? 421 PHE A CB 1 ATOM 3306 C CG . PHE A 1 421 ? -25.262 -27.713 -14.048 1.00 24.69 ? 421 PHE A CG 1 ATOM 3307 C CD1 . PHE A 1 421 ? -26.069 -26.672 -14.551 1.00 24.49 ? 421 PHE A CD1 1 ATOM 3308 C CD2 . PHE A 1 421 ? -25.720 -29.043 -14.165 1.00 24.89 ? 421 PHE A CD2 1 ATOM 3309 C CE1 . PHE A 1 421 ? -27.346 -26.943 -15.079 1.00 24.31 ? 421 PHE A CE1 1 ATOM 3310 C CE2 . PHE A 1 421 ? -26.968 -29.314 -14.753 1.00 25.89 ? 421 PHE A CE2 1 ATOM 3311 C CZ . PHE A 1 421 ? -27.789 -28.256 -15.188 1.00 21.91 ? 421 PHE A CZ 1 ATOM 3312 N N . GLU A 1 422 ? -25.540 -27.805 -10.445 1.00 23.25 ? 422 GLU A N 1 ATOM 3313 C CA . GLU A 1 422 ? -26.026 -28.780 -9.512 1.00 25.89 ? 422 GLU A CA 1 ATOM 3314 C C . GLU A 1 422 ? -27.493 -29.080 -9.644 1.00 27.04 ? 422 GLU A C 1 ATOM 3315 O O . GLU A 1 422 ? -28.098 -29.551 -8.689 1.00 26.47 ? 422 GLU A O 1 ATOM 3316 C CB . GLU A 1 422 ? -25.627 -28.428 -8.065 1.00 27.62 ? 422 GLU A CB 1 ATOM 3317 C CG . GLU A 1 422 ? -25.735 -26.972 -7.712 1.00 30.63 ? 422 GLU A CG 1 ATOM 3318 C CD . GLU A 1 422 ? -25.283 -26.695 -6.288 1.00 33.68 ? 422 GLU A CD 1 ATOM 3319 O OE1 . GLU A 1 422 ? -24.360 -27.381 -5.832 1.00 33.60 ? 422 GLU A OE1 1 ATOM 3320 O OE2 . GLU A 1 422 ? -25.854 -25.787 -5.644 1.00 34.86 ? 422 GLU A OE2 1 ATOM 3321 N N . HIS A 1 423 ? -28.059 -28.911 -10.845 1.00 26.64 ? 423 HIS A N 1 ATOM 3322 C CA . HIS A 1 423 ? -29.466 -29.253 -11.020 1.00 27.00 ? 423 HIS A CA 1 ATOM 3323 C C . HIS A 1 423 ? -29.652 -30.575 -11.764 1.00 27.71 ? 423 HIS A C 1 ATOM 3324 O O . HIS A 1 423 ? -29.131 -30.747 -12.883 1.00 26.45 ? 423 HIS A O 1 ATOM 3325 C CB . HIS A 1 423 ? -30.197 -28.153 -11.770 1.00 27.70 ? 423 HIS A CB 1 ATOM 3326 C CG . HIS A 1 423 ? -31.621 -28.505 -12.061 1.00 30.64 ? 423 HIS A CG 1 ATOM 3327 N ND1 . HIS A 1 423 ? -32.593 -28.524 -11.079 1.00 31.07 ? 423 HIS A ND1 1 ATOM 3328 C CD2 . HIS A 1 423 ? -32.232 -28.900 -13.207 1.00 29.97 ? 423 HIS A CD2 1 ATOM 3329 C CE1 . HIS A 1 423 ? -33.737 -28.922 -11.609 1.00 31.32 ? 423 HIS A CE1 1 ATOM 3330 N NE2 . HIS A 1 423 ? -33.549 -29.138 -12.902 1.00 30.44 ? 423 HIS A NE2 1 ATOM 3331 N N . ARG A 1 424 ? -30.364 -31.515 -11.132 1.00 27.97 ? 424 ARG A N 1 ATOM 3332 C CA . ARG A 1 424 ? -30.827 -32.744 -11.785 1.00 29.24 ? 424 ARG A CA 1 ATOM 3333 C C . ARG A 1 424 ? -32.145 -32.553 -12.599 1.00 30.14 ? 424 ARG A C 1 ATOM 3334 O O . ARG A 1 424 ? -33.203 -32.242 -12.032 1.00 30.04 ? 424 ARG A O 1 ATOM 3335 C CB . ARG A 1 424 ? -31.024 -33.862 -10.780 1.00 27.73 ? 424 ARG A CB 1 ATOM 3336 C CG . ARG A 1 424 ? -31.473 -35.144 -11.482 1.00 30.28 ? 424 ARG A CG 1 ATOM 3337 C CD . ARG A 1 424 ? -31.495 -36.305 -10.545 1.00 30.86 ? 424 ARG A CD 1 ATOM 3338 N NE . ARG A 1 424 ? -32.314 -37.417 -11.028 1.00 33.92 ? 424 ARG A NE 1 ATOM 3339 C CZ . ARG A 1 424 ? -31.835 -38.598 -11.405 1.00 36.25 ? 424 ARG A CZ 1 ATOM 3340 N NH1 . ARG A 1 424 ? -30.509 -38.839 -11.388 1.00 34.11 ? 424 ARG A NH1 1 ATOM 3341 N NH2 . ARG A 1 424 ? -32.680 -39.559 -11.796 1.00 33.51 ? 424 ARG A NH2 1 ATOM 3342 N N . SER A 1 425 ? -32.066 -32.740 -13.911 1.00 30.87 ? 425 SER A N 1 ATOM 3343 C CA . SER A 1 425 ? -33.209 -32.539 -14.803 1.00 32.41 ? 425 SER A CA 1 ATOM 3344 C C . SER A 1 425 ? -34.445 -33.335 -14.336 1.00 33.13 ? 425 SER A C 1 ATOM 3345 O O . SER A 1 425 ? -34.328 -34.494 -13.908 1.00 34.21 ? 425 SER A O 1 ATOM 3346 C CB . SER A 1 425 ? -32.812 -32.987 -16.186 1.00 32.28 ? 425 SER A CB 1 ATOM 3347 O OG . SER A 1 425 ? -33.943 -33.090 -17.004 1.00 34.11 ? 425 SER A OG 1 ATOM 3348 N N . SER A 1 426 ? -35.614 -32.722 -14.371 1.00 33.25 ? 426 SER A N 1 ATOM 3349 C CA . SER A 1 426 ? -36.830 -33.418 -13.896 1.00 34.95 ? 426 SER A CA 1 ATOM 3350 C C . SER A 1 426 ? -37.131 -34.610 -14.794 1.00 36.20 ? 426 SER A C 1 ATOM 3351 O O . SER A 1 426 ? -37.815 -35.533 -14.368 1.00 36.89 ? 426 SER A O 1 ATOM 3352 C CB . SER A 1 426 ? -38.049 -32.500 -13.865 1.00 34.27 ? 426 SER A CB 1 ATOM 3353 O OG . SER A 1 426 ? -38.229 -31.941 -15.143 1.00 31.13 ? 426 SER A OG 1 ATOM 3354 N N . LYS A 1 427 ? -36.577 -34.619 -16.002 1.00 36.98 ? 427 LYS A N 1 ATOM 3355 C CA . LYS A 1 427 ? -36.818 -35.699 -16.927 1.00 37.41 ? 427 LYS A CA 1 ATOM 3356 C C . LYS A 1 427 ? -35.657 -36.699 -17.041 1.00 38.10 ? 427 LYS A C 1 ATOM 3357 O O . LYS A 1 427 ? -35.678 -37.577 -17.933 1.00 38.72 ? 427 LYS A O 1 ATOM 3358 C CB . LYS A 1 427 ? -37.077 -35.096 -18.318 1.00 37.72 ? 427 LYS A CB 1 ATOM 3359 C CG . LYS A 1 427 ? -37.983 -33.869 -18.277 1.00 41.85 ? 427 LYS A CG 1 ATOM 3360 C CD . LYS A 1 427 ? -38.290 -33.300 -19.684 1.00 43.96 ? 427 LYS A CD 1 ATOM 3361 C CE . LYS A 1 427 ? -38.465 -34.433 -20.750 1.00 46.65 ? 427 LYS A CE 1 ATOM 3362 N NZ . LYS A 1 427 ? -38.297 -33.896 -22.140 1.00 46.96 ? 427 LYS A NZ 1 ATOM 3363 N N . LEU A 1 428 ? -34.626 -36.602 -16.203 1.00 36.37 ? 428 LEU A N 1 ATOM 3364 C CA . LEU A 1 428 ? -33.502 -37.505 -16.398 1.00 34.80 ? 428 LEU A CA 1 ATOM 3365 C C . LEU A 1 428 ? -34.029 -38.949 -16.428 1.00 33.47 ? 428 LEU A C 1 ATOM 3366 O O . LEU A 1 428 ? -34.753 -39.340 -15.511 1.00 33.63 ? 428 LEU A O 1 ATOM 3367 C CB . LEU A 1 428 ? -32.479 -37.332 -15.258 1.00 35.86 ? 428 LEU A CB 1 ATOM 3368 C CG . LEU A 1 428 ? -30.952 -37.305 -15.541 1.00 37.59 ? 428 LEU A CG 1 ATOM 3369 C CD1 . LEU A 1 428 ? -30.312 -38.658 -15.557 1.00 38.13 ? 428 LEU A CD1 1 ATOM 3370 C CD2 . LEU A 1 428 ? -30.611 -36.598 -16.819 1.00 36.27 ? 428 LEU A CD2 1 ATOM 3371 N N . PRO A 1 429 ? -33.686 -39.751 -17.476 1.00 31.77 ? 429 PRO A N 1 ATOM 3372 C CA . PRO A 1 429 ? -34.082 -41.192 -17.540 1.00 30.64 ? 429 PRO A CA 1 ATOM 3373 C C . PRO A 1 429 ? -33.214 -42.109 -16.680 1.00 30.60 ? 429 PRO A C 1 ATOM 3374 O O . PRO A 1 429 ? -33.579 -43.261 -16.412 1.00 29.90 ? 429 PRO A O 1 ATOM 3375 C CB . PRO A 1 429 ? -33.871 -41.563 -19.002 1.00 30.50 ? 429 PRO A CB 1 ATOM 3376 C CG . PRO A 1 429 ? -32.888 -40.546 -19.542 1.00 30.75 ? 429 PRO A CG 1 ATOM 3377 C CD . PRO A 1 429 ? -33.122 -39.269 -18.749 1.00 31.05 ? 429 PRO A CD 1 ATOM 3378 N N . TRP A 1 430 ? -32.069 -41.597 -16.228 1.00 29.38 ? 430 TRP A N 1 ATOM 3379 C CA . TRP A 1 430 ? -31.174 -42.381 -15.411 1.00 28.66 ? 430 TRP A CA 1 ATOM 3380 C C . TRP A 1 430 ? -31.672 -42.383 -13.957 1.00 28.28 ? 430 TRP A C 1 ATOM 3381 O O . TRP A 1 430 ? -32.413 -41.492 -13.541 1.00 28.59 ? 430 TRP A O 1 ATOM 3382 C CB . TRP A 1 430 ? -29.803 -41.743 -15.501 1.00 28.54 ? 430 TRP A CB 1 ATOM 3383 C CG . TRP A 1 430 ? -29.161 -41.777 -16.865 1.00 26.12 ? 430 TRP A CG 1 ATOM 3384 C CD1 . TRP A 1 430 ? -29.139 -40.764 -17.815 1.00 26.72 ? 430 TRP A CD1 1 ATOM 3385 C CD2 . TRP A 1 430 ? -28.453 -42.878 -17.438 1.00 22.98 ? 430 TRP A CD2 1 ATOM 3386 N NE1 . TRP A 1 430 ? -28.465 -41.203 -18.953 1.00 22.45 ? 430 TRP A NE1 1 ATOM 3387 C CE2 . TRP A 1 430 ? -28.012 -42.483 -18.721 1.00 24.17 ? 430 TRP A CE2 1 ATOM 3388 C CE3 . TRP A 1 430 ? -28.153 -44.173 -16.996 1.00 24.58 ? 430 TRP A CE3 1 ATOM 3389 C CZ2 . TRP A 1 430 ? -27.266 -43.329 -19.546 1.00 22.28 ? 430 TRP A CZ2 1 ATOM 3390 C CZ3 . TRP A 1 430 ? -27.387 -45.009 -17.837 1.00 22.66 ? 430 TRP A CZ3 1 ATOM 3391 C CH2 . TRP A 1 430 ? -26.963 -44.579 -19.080 1.00 21.62 ? 430 TRP A CH2 1 ATOM 3392 N N . PRO A 1 431 ? -31.245 -43.350 -13.149 1.00 28.35 ? 431 PRO A N 1 ATOM 3393 C CA . PRO A 1 431 ? -31.863 -43.372 -11.803 1.00 28.41 ? 431 PRO A CA 1 ATOM 3394 C C . PRO A 1 431 ? -31.350 -42.269 -10.865 1.00 30.23 ? 431 PRO A C 1 ATOM 3395 O O . PRO A 1 431 ? -30.344 -41.617 -11.159 1.00 30.77 ? 431 PRO A O 1 ATOM 3396 C CB . PRO A 1 431 ? -31.463 -44.731 -11.256 1.00 28.15 ? 431 PRO A CB 1 ATOM 3397 C CG . PRO A 1 431 ? -30.204 -45.086 -12.004 1.00 28.19 ? 431 PRO A CG 1 ATOM 3398 C CD . PRO A 1 431 ? -30.371 -44.506 -13.395 1.00 27.78 ? 431 PRO A CD 1 ATOM 3399 N N . GLU A 1 432 ? -32.017 -42.094 -9.724 1.00 30.76 ? 432 GLU A N 1 ATOM 3400 C CA . GLU A 1 432 ? -31.755 -41.007 -8.784 1.00 31.43 ? 432 GLU A CA 1 ATOM 3401 C C . GLU A 1 432 ? -30.334 -41.045 -8.217 1.00 31.24 ? 432 GLU A C 1 ATOM 3402 O O . GLU A 1 432 ? -29.679 -40.021 -8.108 1.00 31.80 ? 432 GLU A O 1 ATOM 3403 C CB . GLU A 1 432 ? -32.770 -41.058 -7.619 1.00 31.69 ? 432 GLU A CB 1 ATOM 3404 C CG . GLU A 1 432 ? -34.151 -40.606 -7.962 0.50 33.58 ? 432 GLU A CG 1 ATOM 3405 C CD . GLU A 1 432 ? -34.378 -39.160 -7.589 0.50 37.09 ? 432 GLU A CD 1 ATOM 3406 O OE1 . GLU A 1 432 ? -33.380 -38.441 -7.406 0.50 36.72 ? 432 GLU A OE1 1 ATOM 3407 O OE2 . GLU A 1 432 ? -35.557 -38.736 -7.484 0.50 40.15 ? 432 GLU A OE2 1 ATOM 3408 N N . TRP A 1 433 ? -29.849 -42.225 -7.867 1.00 31.14 ? 433 TRP A N 1 ATOM 3409 C CA . TRP A 1 433 ? -28.542 -42.309 -7.240 1.00 30.59 ? 433 TRP A CA 1 ATOM 3410 C C . TRP A 1 433 ? -27.457 -41.698 -8.133 1.00 31.28 ? 433 TRP A C 1 ATOM 3411 O O . TRP A 1 433 ? -26.381 -41.362 -7.635 1.00 31.46 ? 433 TRP A O 1 ATOM 3412 C CB . TRP A 1 433 ? -28.185 -43.762 -6.922 1.00 30.34 ? 433 TRP A CB 1 ATOM 3413 C CG . TRP A 1 433 ? -27.818 -44.676 -8.095 1.00 30.04 ? 433 TRP A CG 1 ATOM 3414 C CD1 . TRP A 1 433 ? -28.600 -45.632 -8.626 1.00 30.28 ? 433 TRP A CD1 1 ATOM 3415 C CD2 . TRP A 1 433 ? -26.525 -44.805 -8.757 1.00 28.99 ? 433 TRP A CD2 1 ATOM 3416 N NE1 . TRP A 1 433 ? -27.921 -46.312 -9.626 1.00 29.92 ? 433 TRP A NE1 1 ATOM 3417 C CE2 . TRP A 1 433 ? -26.644 -45.826 -9.710 1.00 28.06 ? 433 TRP A CE2 1 ATOM 3418 C CE3 . TRP A 1 433 ? -25.292 -44.151 -8.633 1.00 29.51 ? 433 TRP A CE3 1 ATOM 3419 C CZ2 . TRP A 1 433 ? -25.584 -46.207 -10.551 1.00 29.58 ? 433 TRP A CZ2 1 ATOM 3420 C CZ3 . TRP A 1 433 ? -24.235 -44.517 -9.503 1.00 26.91 ? 433 TRP A CZ3 1 ATOM 3421 C CH2 . TRP A 1 433 ? -24.397 -45.530 -10.446 1.00 27.64 ? 433 TRP A CH2 1 ATOM 3422 N N . MET A 1 434 ? -27.714 -41.569 -9.444 1.00 29.71 ? 434 MET A N 1 ATOM 3423 C CA . MET A 1 434 ? -26.655 -41.038 -10.339 1.00 29.10 ? 434 MET A CA 1 ATOM 3424 C C . MET A 1 434 ? -26.604 -39.530 -10.310 1.00 27.03 ? 434 MET A C 1 ATOM 3425 O O . MET A 1 434 ? -25.686 -38.932 -10.858 1.00 27.78 ? 434 MET A O 1 ATOM 3426 C CB . MET A 1 434 ? -26.811 -41.534 -11.786 1.00 29.45 ? 434 MET A CB 1 ATOM 3427 C CG . MET A 1 434 ? -26.696 -43.061 -11.937 1.00 31.66 ? 434 MET A CG 1 ATOM 3428 S SD . MET A 1 434 ? -26.791 -43.597 -13.655 1.00 33.53 ? 434 MET A SD 1 ATOM 3429 C CE . MET A 1 434 ? -25.169 -43.864 -14.192 1.00 33.10 ? 434 MET A CE 1 ATOM 3430 N N . GLY A 1 435 ? -27.602 -38.914 -9.704 1.00 25.67 ? 435 GLY A N 1 ATOM 3431 C CA . GLY A 1 435 ? -27.559 -37.483 -9.390 1.00 25.04 ? 435 GLY A CA 1 ATOM 3432 C C . GLY A 1 435 ? -27.490 -36.540 -10.583 1.00 25.17 ? 435 GLY A C 1 ATOM 3433 O O . GLY A 1 435 ? -28.191 -36.763 -11.568 1.00 23.97 ? 435 GLY A O 1 ATOM 3434 N N . VAL A 1 436 ? -26.677 -35.472 -10.488 1.00 23.84 ? 436 VAL A N 1 ATOM 3435 C CA . VAL A 1 436 ? -26.506 -34.478 -11.581 1.00 23.35 ? 436 VAL A CA 1 ATOM 3436 C C . VAL A 1 436 ? -25.373 -34.905 -12.517 1.00 24.34 ? 436 VAL A C 1 ATOM 3437 O O . VAL A 1 436 ? -24.181 -34.550 -12.317 1.00 24.32 ? 436 VAL A O 1 ATOM 3438 C CB . VAL A 1 436 ? -26.200 -33.034 -10.991 1.00 23.16 ? 436 VAL A CB 1 ATOM 3439 C CG1 . VAL A 1 436 ? -26.133 -31.946 -12.101 1.00 22.66 ? 436 VAL A CG1 1 ATOM 3440 C CG2 . VAL A 1 436 ? -27.221 -32.670 -9.840 1.00 21.71 ? 436 VAL A CG2 1 ATOM 3441 N N . MET A 1 437 ? -25.736 -35.643 -13.562 1.00 22.82 ? 437 MET A N 1 ATOM 3442 C CA . MET A 1 437 ? -24.797 -36.385 -14.319 1.00 22.36 ? 437 MET A CA 1 ATOM 3443 C C . MET A 1 437 ? -23.968 -35.578 -15.318 1.00 22.55 ? 437 MET A C 1 ATOM 3444 O O . MET A 1 437 ? -24.357 -34.493 -15.762 1.00 23.07 ? 437 MET A O 1 ATOM 3445 C CB . MET A 1 437 ? -25.553 -37.477 -15.100 1.00 22.92 ? 437 MET A CB 1 ATOM 3446 C CG . MET A 1 437 ? -26.134 -38.569 -14.207 1.00 27.26 ? 437 MET A CG 1 ATOM 3447 S SD . MET A 1 437 ? -27.158 -39.728 -15.151 1.00 26.78 ? 437 MET A SD 1 ATOM 3448 C CE . MET A 1 437 ? -25.965 -40.383 -16.264 1.00 18.94 ? 437 MET A CE 1 ATOM 3449 N N . HIS A 1 438 ? -22.852 -36.161 -15.724 1.00 21.82 ? 438 HIS A N 1 ATOM 3450 C CA . HIS A 1 438 ? -22.102 -35.650 -16.872 1.00 22.04 ? 438 HIS A CA 1 ATOM 3451 C C . HIS A 1 438 ? -23.038 -35.582 -18.091 1.00 23.62 ? 438 HIS A C 1 ATOM 3452 O O . HIS A 1 438 ? -23.720 -36.568 -18.407 1.00 24.13 ? 438 HIS A O 1 ATOM 3453 C CB . HIS A 1 438 ? -20.997 -36.664 -17.143 1.00 21.23 ? 438 HIS A CB 1 ATOM 3454 C CG . HIS A 1 438 ? -20.107 -36.332 -18.309 1.00 22.49 ? 438 HIS A CG 1 ATOM 3455 N ND1 . HIS A 1 438 ? -19.089 -35.423 -18.220 1.00 19.54 ? 438 HIS A ND1 1 ATOM 3456 C CD2 . HIS A 1 438 ? -20.052 -36.833 -19.569 1.00 21.23 ? 438 HIS A CD2 1 ATOM 3457 C CE1 . HIS A 1 438 ? -18.442 -35.367 -19.374 1.00 25.51 ? 438 HIS A CE1 1 ATOM 3458 N NE2 . HIS A 1 438 ? -19.007 -36.215 -20.205 1.00 27.17 ? 438 HIS A NE2 1 ATOM 3459 N N . GLY A 1 439 ? -23.059 -34.428 -18.763 1.00 24.27 ? 439 GLY A N 1 ATOM 3460 C CA . GLY A 1 439 ? -23.702 -34.247 -20.081 1.00 23.51 ? 439 GLY A CA 1 ATOM 3461 C C . GLY A 1 439 ? -25.038 -33.565 -19.946 1.00 24.47 ? 439 GLY A C 1 ATOM 3462 O O . GLY A 1 439 ? -25.637 -33.141 -20.934 1.00 25.28 ? 439 GLY A O 1 ATOM 3463 N N . TYR A 1 440 ? -25.529 -33.441 -18.716 1.00 23.18 ? 440 TYR A N 1 ATOM 3464 C CA . TYR A 1 440 ? -26.898 -33.043 -18.532 1.00 23.27 ? 440 TYR A CA 1 ATOM 3465 C C . TYR A 1 440 ? -27.104 -31.591 -18.147 1.00 22.20 ? 440 TYR A C 1 ATOM 3466 O O . TYR A 1 440 ? -28.176 -31.202 -17.693 1.00 22.78 ? 440 TYR A O 1 ATOM 3467 C CB . TYR A 1 440 ? -27.624 -34.028 -17.585 1.00 23.59 ? 440 TYR A CB 1 ATOM 3468 C CG . TYR A 1 440 ? -27.872 -35.333 -18.374 1.00 25.14 ? 440 TYR A CG 1 ATOM 3469 C CD1 . TYR A 1 440 ? -26.963 -36.369 -18.333 1.00 23.85 ? 440 TYR A CD1 1 ATOM 3470 C CD2 . TYR A 1 440 ? -28.976 -35.461 -19.239 1.00 24.19 ? 440 TYR A CD2 1 ATOM 3471 C CE1 . TYR A 1 440 ? -27.155 -37.523 -19.065 1.00 24.56 ? 440 TYR A CE1 1 ATOM 3472 C CE2 . TYR A 1 440 ? -29.166 -36.611 -19.988 1.00 22.15 ? 440 TYR A CE2 1 ATOM 3473 C CZ . TYR A 1 440 ? -28.275 -37.641 -19.881 1.00 27.32 ? 440 TYR A CZ 1 ATOM 3474 O OH . TYR A 1 440 ? -28.463 -38.804 -20.613 1.00 26.97 ? 440 TYR A OH 1 ATOM 3475 N N . GLU A 1 441 ? -26.076 -30.788 -18.331 1.00 21.90 ? 441 GLU A N 1 ATOM 3476 C CA . GLU A 1 441 ? -26.244 -29.315 -18.289 1.00 21.32 ? 441 GLU A CA 1 ATOM 3477 C C . GLU A 1 441 ? -26.522 -28.848 -19.730 1.00 21.05 ? 441 GLU A C 1 ATOM 3478 O O . GLU A 1 441 ? -26.989 -27.746 -20.008 1.00 21.49 ? 441 GLU A O 1 ATOM 3479 C CB . GLU A 1 441 ? -24.942 -28.663 -17.776 1.00 20.38 ? 441 GLU A CB 1 ATOM 3480 C CG . GLU A 1 441 ? -23.921 -28.312 -18.838 1.00 18.49 ? 441 GLU A CG 1 ATOM 3481 C CD . GLU A 1 441 ? -23.137 -29.528 -19.332 1.00 22.59 ? 441 GLU A CD 1 ATOM 3482 O OE1 . GLU A 1 441 ? -23.365 -30.662 -18.810 1.00 20.20 ? 441 GLU A OE1 1 ATOM 3483 O OE2 . GLU A 1 441 ? -22.268 -29.329 -20.230 1.00 21.55 ? 441 GLU A OE2 1 ATOM 3484 N N . ILE A 1 442 ? -26.161 -29.703 -20.666 1.00 22.28 ? 442 ILE A N 1 ATOM 3485 C CA . ILE A 1 442 ? -26.118 -29.271 -22.072 1.00 22.41 ? 442 ILE A CA 1 ATOM 3486 C C . ILE A 1 442 ? -27.463 -28.796 -22.517 1.00 23.12 ? 442 ILE A C 1 ATOM 3487 O O . ILE A 1 442 ? -27.590 -27.687 -23.073 1.00 25.10 ? 442 ILE A O 1 ATOM 3488 C CB . ILE A 1 442 ? -25.633 -30.424 -22.981 1.00 22.00 ? 442 ILE A CB 1 ATOM 3489 C CG1 . ILE A 1 442 ? -24.204 -30.824 -22.600 1.00 19.09 ? 442 ILE A CG1 1 ATOM 3490 C CG2 . ILE A 1 442 ? -25.709 -30.022 -24.429 1.00 24.61 ? 442 ILE A CG2 1 ATOM 3491 C CD1 . ILE A 1 442 ? -23.705 -32.055 -23.326 1.00 15.77 ? 442 ILE A CD1 1 ATOM 3492 N N . GLU A 1 443 ? -28.496 -29.603 -22.262 1.00 23.37 ? 443 GLU A N 1 ATOM 3493 C CA . GLU A 1 443 ? -29.850 -29.224 -22.681 1.00 23.27 ? 443 GLU A CA 1 ATOM 3494 C C . GLU A 1 443 ? -30.267 -27.892 -22.037 1.00 24.41 ? 443 GLU A C 1 ATOM 3495 O O . GLU A 1 443 ? -31.108 -27.136 -22.580 1.00 24.25 ? 443 GLU A O 1 ATOM 3496 C CB . GLU A 1 443 ? -30.859 -30.322 -22.339 1.00 22.80 ? 443 GLU A CB 1 ATOM 3497 C CG . GLU A 1 443 ? -30.934 -30.677 -20.859 1.00 27.05 ? 443 GLU A CG 1 ATOM 3498 C CD . GLU A 1 443 ? -31.476 -32.069 -20.642 1.00 29.25 ? 443 GLU A CD 1 ATOM 3499 O OE1 . GLU A 1 443 ? -30.723 -33.092 -20.840 1.00 26.57 ? 443 GLU A OE1 1 ATOM 3500 O OE2 . GLU A 1 443 ? -32.667 -32.102 -20.275 1.00 31.74 ? 443 GLU A OE2 1 ATOM 3501 N N . PHE A 1 444 ? -29.684 -27.564 -20.877 1.00 23.75 ? 444 PHE A N 1 ATOM 3502 C CA . PHE A 1 444 ? -29.990 -26.252 -20.304 1.00 22.72 ? 444 PHE A CA 1 ATOM 3503 C C . PHE A 1 444 ? -29.312 -25.089 -21.023 1.00 22.87 ? 444 PHE A C 1 ATOM 3504 O O . PHE A 1 444 ? -29.887 -24.000 -21.192 1.00 23.49 ? 444 PHE A O 1 ATOM 3505 C CB . PHE A 1 444 ? -29.653 -26.259 -18.834 1.00 22.26 ? 444 PHE A CB 1 ATOM 3506 C CG . PHE A 1 444 ? -30.682 -27.043 -18.014 1.00 21.90 ? 444 PHE A CG 1 ATOM 3507 C CD1 . PHE A 1 444 ? -30.687 -28.423 -18.011 1.00 19.30 ? 444 PHE A CD1 1 ATOM 3508 C CD2 . PHE A 1 444 ? -31.667 -26.387 -17.319 1.00 22.37 ? 444 PHE A CD2 1 ATOM 3509 C CE1 . PHE A 1 444 ? -31.668 -29.114 -17.331 1.00 19.59 ? 444 PHE A CE1 1 ATOM 3510 C CE2 . PHE A 1 444 ? -32.619 -27.083 -16.614 1.00 20.91 ? 444 PHE A CE2 1 ATOM 3511 C CZ . PHE A 1 444 ? -32.604 -28.444 -16.621 1.00 21.10 ? 444 PHE A CZ 1 ATOM 3512 N N . VAL A 1 445 ? -28.073 -25.295 -21.410 1.00 22.78 ? 445 VAL A N 1 ATOM 3513 C CA . VAL A 1 445 ? -27.317 -24.284 -22.134 1.00 22.36 ? 445 VAL A CA 1 ATOM 3514 C C . VAL A 1 445 ? -27.978 -23.988 -23.495 1.00 24.02 ? 445 VAL A C 1 ATOM 3515 O O . VAL A 1 445 ? -27.976 -22.824 -23.919 1.00 24.34 ? 445 VAL A O 1 ATOM 3516 C CB . VAL A 1 445 ? -25.885 -24.802 -22.386 1.00 22.53 ? 445 VAL A CB 1 ATOM 3517 C CG1 . VAL A 1 445 ? -25.146 -23.953 -23.473 1.00 17.88 ? 445 VAL A CG1 1 ATOM 3518 C CG2 . VAL A 1 445 ? -25.115 -24.901 -21.051 1.00 22.08 ? 445 VAL A CG2 1 ATOM 3519 N N . PHE A 1 446 ? -28.504 -25.045 -24.180 1.00 23.39 ? 446 PHE A N 1 ATOM 3520 C CA . PHE A 1 446 ? -29.120 -24.910 -25.533 1.00 23.13 ? 446 PHE A CA 1 ATOM 3521 C C . PHE A 1 446 ? -30.587 -24.451 -25.496 1.00 24.73 ? 446 PHE A C 1 ATOM 3522 O O . PHE A 1 446 ? -31.226 -24.158 -26.533 1.00 26.30 ? 446 PHE A O 1 ATOM 3523 C CB . PHE A 1 446 ? -28.924 -26.207 -26.324 1.00 21.23 ? 446 PHE A CB 1 ATOM 3524 C CG . PHE A 1 446 ? -27.576 -26.300 -27.006 1.00 17.82 ? 446 PHE A CG 1 ATOM 3525 C CD1 . PHE A 1 446 ? -26.467 -26.849 -26.341 1.00 18.92 ? 446 PHE A CD1 1 ATOM 3526 C CD2 . PHE A 1 446 ? -27.404 -25.820 -28.294 1.00 16.83 ? 446 PHE A CD2 1 ATOM 3527 C CE1 . PHE A 1 446 ? -25.205 -26.924 -26.969 1.00 16.36 ? 446 PHE A CE1 1 ATOM 3528 C CE2 . PHE A 1 446 ? -26.163 -25.916 -28.950 1.00 17.00 ? 446 PHE A CE2 1 ATOM 3529 C CZ . PHE A 1 446 ? -25.069 -26.461 -28.300 1.00 16.60 ? 446 PHE A CZ 1 ATOM 3530 N N . GLY A 1 447 ? -31.159 -24.418 -24.298 1.00 25.68 ? 447 GLY A N 1 ATOM 3531 C CA . GLY A 1 447 ? -32.459 -23.781 -24.160 1.00 25.62 ? 447 GLY A CA 1 ATOM 3532 C C . GLY A 1 447 ? -33.627 -24.744 -24.287 1.00 26.37 ? 447 GLY A C 1 ATOM 3533 O O . GLY A 1 447 ? -34.761 -24.320 -24.394 1.00 25.06 ? 447 GLY A O 1 ATOM 3534 N N . LEU A 1 448 ? -33.388 -26.042 -24.218 1.00 26.68 ? 448 LEU A N 1 ATOM 3535 C CA . LEU A 1 448 ? -34.511 -26.892 -24.482 1.00 28.48 ? 448 LEU A CA 1 ATOM 3536 C C . LEU A 1 448 ? -35.677 -26.676 -23.502 1.00 29.64 ? 448 LEU A C 1 ATOM 3537 O O . LEU A 1 448 ? -36.852 -26.789 -23.895 1.00 30.00 ? 448 LEU A O 1 ATOM 3538 C CB . LEU A 1 448 ? -34.130 -28.353 -24.575 1.00 28.27 ? 448 LEU A CB 1 ATOM 3539 C CG . LEU A 1 448 ? -33.017 -28.881 -25.472 1.00 27.37 ? 448 LEU A CG 1 ATOM 3540 C CD1 . LEU A 1 448 ? -33.433 -30.228 -25.906 1.00 26.88 ? 448 LEU A CD1 1 ATOM 3541 C CD2 . LEU A 1 448 ? -32.575 -28.020 -26.625 1.00 25.57 ? 448 LEU A CD2 1 ATOM 3542 N N . PRO A 1 449 ? -35.356 -26.381 -22.232 1.00 29.72 ? 449 PRO A N 1 ATOM 3543 C CA . PRO A 1 449 ? -36.421 -26.133 -21.245 1.00 30.81 ? 449 PRO A CA 1 ATOM 3544 C C . PRO A 1 449 ? -37.203 -24.868 -21.477 1.00 30.96 ? 449 PRO A C 1 ATOM 3545 O O . PRO A 1 449 ? -38.146 -24.615 -20.741 1.00 31.55 ? 449 PRO A O 1 ATOM 3546 C CB . PRO A 1 449 ? -35.670 -26.033 -19.891 1.00 29.32 ? 449 PRO A CB 1 ATOM 3547 C CG . PRO A 1 449 ? -34.343 -26.736 -20.144 1.00 28.93 ? 449 PRO A CG 1 ATOM 3548 C CD . PRO A 1 449 ? -34.022 -26.467 -21.609 1.00 28.89 ? 449 PRO A CD 1 ATOM 3549 N N . LEU A 1 450 ? -36.803 -24.062 -22.445 1.00 32.72 ? 450 LEU A N 1 ATOM 3550 C CA . LEU A 1 450 ? -37.533 -22.838 -22.758 1.00 34.58 ? 450 LEU A CA 1 ATOM 3551 C C . LEU A 1 450 ? -38.816 -23.220 -23.502 1.00 37.54 ? 450 LEU A C 1 ATOM 3552 O O . LEU A 1 450 ? -39.763 -22.444 -23.583 1.00 38.33 ? 450 LEU A O 1 ATOM 3553 C CB . LEU A 1 450 ? -36.683 -21.868 -23.579 1.00 32.53 ? 450 LEU A CB 1 ATOM 3554 C CG . LEU A 1 450 ? -35.477 -21.349 -22.762 1.00 31.64 ? 450 LEU A CG 1 ATOM 3555 C CD1 . LEU A 1 450 ? -34.598 -20.367 -23.526 1.00 28.74 ? 450 LEU A CD1 1 ATOM 3556 C CD2 . LEU A 1 450 ? -35.881 -20.778 -21.333 1.00 28.95 ? 450 LEU A CD2 1 ATOM 3557 N N . GLU A 1 451 ? -38.840 -24.433 -24.026 1.00 41.16 ? 451 GLU A N 1 ATOM 3558 C CA . GLU A 1 451 ? -39.978 -24.901 -24.784 1.00 44.74 ? 451 GLU A CA 1 ATOM 3559 C C . GLU A 1 451 ? -40.935 -25.548 -23.792 1.00 46.84 ? 451 GLU A C 1 ATOM 3560 O O . GLU A 1 451 ? -40.705 -26.665 -23.319 1.00 46.63 ? 451 GLU A O 1 ATOM 3561 C CB . GLU A 1 451 ? -39.529 -25.896 -25.837 1.00 44.32 ? 451 GLU A CB 1 ATOM 3562 C CG . GLU A 1 451 ? -40.663 -26.691 -26.402 1.00 48.42 ? 451 GLU A CG 1 ATOM 3563 C CD . GLU A 1 451 ? -41.415 -25.905 -27.483 1.00 53.87 ? 451 GLU A CD 1 ATOM 3564 O OE1 . GLU A 1 451 ? -42.474 -25.269 -27.166 1.00 55.22 ? 451 GLU A OE1 1 ATOM 3565 O OE2 . GLU A 1 451 ? -40.913 -25.899 -28.644 1.00 54.97 ? 451 GLU A OE2 1 ATOM 3566 N N . ARG A 1 452 ? -41.983 -24.808 -23.441 1.00 50.66 ? 452 ARG A N 1 ATOM 3567 C CA . ARG A 1 452 ? -43.042 -25.304 -22.535 1.00 54.42 ? 452 ARG A CA 1 ATOM 3568 C C . ARG A 1 452 ? -43.717 -26.619 -22.979 1.00 55.60 ? 452 ARG A C 1 ATOM 3569 O O . ARG A 1 452 ? -44.036 -27.484 -22.151 1.00 55.92 ? 452 ARG A O 1 ATOM 3570 C CB . ARG A 1 452 ? -44.101 -24.220 -22.301 1.00 54.76 ? 452 ARG A CB 1 ATOM 3571 C CG . ARG A 1 452 ? -43.534 -22.956 -21.619 1.00 59.13 ? 452 ARG A CG 1 ATOM 3572 C CD . ARG A 1 452 ? -44.648 -21.936 -21.302 1.00 64.90 ? 452 ARG A CD 1 ATOM 3573 N NE . ARG A 1 452 ? -44.155 -20.610 -20.892 1.00 65.89 ? 452 ARG A NE 1 ATOM 3574 C CZ . ARG A 1 452 ? -44.380 -19.490 -21.574 1.00 66.47 ? 452 ARG A CZ 1 ATOM 3575 N NH1 . ARG A 1 452 ? -45.092 -19.529 -22.702 1.00 65.56 ? 452 ARG A NH1 1 ATOM 3576 N NH2 . ARG A 1 452 ? -43.902 -18.332 -21.120 1.00 65.91 ? 452 ARG A NH2 1 ATOM 3577 N N . ARG A 1 453 ? -43.935 -26.772 -24.277 1.00 56.79 ? 453 ARG A N 1 ATOM 3578 C CA . ARG A 1 453 ? -44.587 -27.984 -24.756 1.00 58.67 ? 453 ARG A CA 1 ATOM 3579 C C . ARG A 1 453 ? -43.852 -29.245 -24.276 1.00 58.71 ? 453 ARG A C 1 ATOM 3580 O O . ARG A 1 453 ? -44.344 -30.365 -24.447 1.00 59.46 ? 453 ARG A O 1 ATOM 3581 C CB . ARG A 1 453 ? -44.685 -27.930 -26.278 1.00 58.83 ? 453 ARG A CB 1 ATOM 3582 C CG . ARG A 1 453 ? -45.229 -26.587 -26.739 1.00 62.25 ? 453 ARG A CG 1 ATOM 3583 C CD . ARG A 1 453 ? -46.555 -26.740 -27.432 1.00 67.47 ? 453 ARG A CD 1 ATOM 3584 N NE . ARG A 1 453 ? -46.322 -26.778 -28.878 1.00 73.47 ? 453 ARG A NE 1 ATOM 3585 C CZ . ARG A 1 453 ? -47.167 -27.281 -29.781 1.00 75.64 ? 453 ARG A CZ 1 ATOM 3586 N NH1 . ARG A 1 453 ? -48.329 -27.818 -29.407 1.00 75.98 ? 453 ARG A NH1 1 ATOM 3587 N NH2 . ARG A 1 453 ? -46.838 -27.252 -31.069 1.00 76.58 ? 453 ARG A NH2 1 ATOM 3588 N N . ASP A 1 454 ? -42.694 -29.052 -23.641 1.00 58.22 ? 454 ASP A N 1 ATOM 3589 C CA . ASP A 1 454 ? -41.762 -30.145 -23.357 1.00 57.32 ? 454 ASP A CA 1 ATOM 3590 C C . ASP A 1 454 ? -41.754 -30.800 -21.966 1.00 55.65 ? 454 ASP A C 1 ATOM 3591 O O . ASP A 1 454 ? -40.933 -31.685 -21.708 1.00 55.57 ? 454 ASP A O 1 ATOM 3592 C CB . ASP A 1 454 ? -40.354 -29.689 -23.683 1.00 58.08 ? 454 ASP A CB 1 ATOM 3593 C CG . ASP A 1 454 ? -39.772 -30.433 -24.851 1.00 62.31 ? 454 ASP A CG 1 ATOM 3594 O OD1 . ASP A 1 454 ? -40.542 -30.726 -25.811 1.00 66.89 ? 454 ASP A OD1 1 ATOM 3595 O OD2 . ASP A 1 454 ? -38.541 -30.725 -24.807 1.00 65.77 ? 454 ASP A OD2 1 ATOM 3596 N N . GLN A 1 455 ? -42.624 -30.383 -21.057 1.00 53.38 ? 455 GLN A N 1 ATOM 3597 C CA . GLN A 1 455 ? -42.679 -31.113 -19.790 1.00 51.87 ? 455 GLN A CA 1 ATOM 3598 C C . GLN A 1 455 ? -41.456 -30.915 -18.843 1.00 48.55 ? 455 GLN A C 1 ATOM 3599 O O . GLN A 1 455 ? -41.235 -31.715 -17.962 1.00 48.46 ? 455 GLN A O 1 ATOM 3600 C CB . GLN A 1 455 ? -42.863 -32.620 -20.063 1.00 52.65 ? 455 GLN A CB 1 ATOM 3601 C CG . GLN A 1 455 ? -44.297 -33.176 -19.743 1.00 57.65 ? 455 GLN A CG 1 ATOM 3602 C CD . GLN A 1 455 ? -45.419 -32.585 -20.637 1.00 61.65 ? 455 GLN A CD 1 ATOM 3603 O OE1 . GLN A 1 455 ? -45.190 -32.281 -21.816 1.00 63.57 ? 455 GLN A OE1 1 ATOM 3604 N NE2 . GLN A 1 455 ? -46.635 -32.438 -20.073 1.00 61.06 ? 455 GLN A NE2 1 ATOM 3605 N N . TYR A 1 456 ? -40.662 -29.869 -19.030 1.00 44.91 ? 456 TYR A N 1 ATOM 3606 C CA . TYR A 1 456 ? -39.745 -29.426 -17.959 1.00 40.68 ? 456 TYR A CA 1 ATOM 3607 C C . TYR A 1 456 ? -40.553 -28.569 -16.977 1.00 38.99 ? 456 TYR A C 1 ATOM 3608 O O . TYR A 1 456 ? -41.566 -28.007 -17.363 1.00 37.11 ? 456 TYR A O 1 ATOM 3609 C CB . TYR A 1 456 ? -38.630 -28.583 -18.545 1.00 38.84 ? 456 TYR A CB 1 ATOM 3610 C CG . TYR A 1 456 ? -37.609 -29.308 -19.360 1.00 35.25 ? 456 TYR A CG 1 ATOM 3611 C CD1 . TYR A 1 456 ? -37.675 -29.320 -20.737 1.00 33.73 ? 456 TYR A CD1 1 ATOM 3612 C CD2 . TYR A 1 456 ? -36.512 -29.922 -18.752 1.00 32.39 ? 456 TYR A CD2 1 ATOM 3613 C CE1 . TYR A 1 456 ? -36.677 -29.948 -21.514 1.00 30.75 ? 456 TYR A CE1 1 ATOM 3614 C CE2 . TYR A 1 456 ? -35.510 -30.528 -19.492 1.00 30.71 ? 456 TYR A CE2 1 ATOM 3615 C CZ . TYR A 1 456 ? -35.593 -30.545 -20.882 1.00 32.90 ? 456 TYR A CZ 1 ATOM 3616 O OH . TYR A 1 456 ? -34.594 -31.149 -21.627 1.00 30.59 ? 456 TYR A OH 1 ATOM 3617 N N . THR A 1 457 ? -40.121 -28.470 -15.716 1.00 37.27 ? 457 THR A N 1 ATOM 3618 C CA . THR A 1 457 ? -40.830 -27.640 -14.751 1.00 35.40 ? 457 THR A CA 1 ATOM 3619 C C . THR A 1 457 ? -40.630 -26.159 -15.040 1.00 35.13 ? 457 THR A C 1 ATOM 3620 O O . THR A 1 457 ? -39.791 -25.767 -15.856 1.00 34.15 ? 457 THR A O 1 ATOM 3621 C CB . THR A 1 457 ? -40.334 -27.861 -13.323 1.00 35.60 ? 457 THR A CB 1 ATOM 3622 O OG1 . THR A 1 457 ? -38.973 -27.429 -13.251 1.00 35.06 ? 457 THR A OG1 1 ATOM 3623 C CG2 . THR A 1 457 ? -40.426 -29.345 -12.921 1.00 35.02 ? 457 THR A CG2 1 ATOM 3624 N N . LYS A 1 458 ? -41.387 -25.327 -14.333 1.00 34.11 ? 458 LYS A N 1 ATOM 3625 C CA . LYS A 1 458 ? -41.259 -23.883 -14.480 1.00 34.81 ? 458 LYS A CA 1 ATOM 3626 C C . LYS A 1 458 ? -39.909 -23.377 -13.918 1.00 33.87 ? 458 LYS A C 1 ATOM 3627 O O . LYS A 1 458 ? -39.309 -22.446 -14.449 1.00 34.69 ? 458 LYS A O 1 ATOM 3628 C CB . LYS A 1 458 ? -42.421 -23.182 -13.750 1.00 34.74 ? 458 LYS A CB 1 ATOM 3629 C CG . LYS A 1 458 ? -42.312 -21.706 -13.776 1.00 37.56 ? 458 LYS A CG 1 ATOM 3630 C CD . LYS A 1 458 ? -43.007 -21.184 -14.966 1.00 42.63 ? 458 LYS A CD 1 ATOM 3631 C CE . LYS A 1 458 ? -42.268 -19.982 -15.501 1.00 48.21 ? 458 LYS A CE 1 ATOM 3632 N NZ . LYS A 1 458 ? -42.980 -19.507 -16.746 1.00 50.49 ? 458 LYS A NZ 1 ATOM 3633 N N . ALA A 1 459 ? -39.452 -24.001 -12.834 1.00 32.86 ? 459 ALA A N 1 ATOM 3634 C CA . ALA A 1 459 ? -38.211 -23.612 -12.234 1.00 31.44 ? 459 ALA A CA 1 ATOM 3635 C C . ALA A 1 459 ? -37.123 -23.919 -13.245 1.00 31.57 ? 459 ALA A C 1 ATOM 3636 O O . ALA A 1 459 ? -36.122 -23.218 -13.268 1.00 31.99 ? 459 ALA A O 1 ATOM 3637 C CB . ALA A 1 459 ? -37.963 -24.348 -10.897 1.00 31.13 ? 459 ALA A CB 1 ATOM 3638 N N . GLU A 1 460 ? -37.307 -24.939 -14.081 1.00 30.38 ? 460 GLU A N 1 ATOM 3639 C CA . GLU A 1 460 ? -36.267 -25.294 -15.073 1.00 29.86 ? 460 GLU A CA 1 ATOM 3640 C C . GLU A 1 460 ? -36.245 -24.358 -16.291 1.00 29.91 ? 460 GLU A C 1 ATOM 3641 O O . GLU A 1 460 ? -35.194 -23.923 -16.747 1.00 30.58 ? 460 GLU A O 1 ATOM 3642 C CB . GLU A 1 460 ? -36.432 -26.753 -15.491 1.00 30.05 ? 460 GLU A CB 1 ATOM 3643 C CG . GLU A 1 460 ? -36.102 -27.716 -14.351 1.00 30.73 ? 460 GLU A CG 1 ATOM 3644 C CD . GLU A 1 460 ? -36.278 -29.173 -14.719 1.00 33.92 ? 460 GLU A CD 1 ATOM 3645 O OE1 . GLU A 1 460 ? -37.247 -29.495 -15.439 1.00 33.04 ? 460 GLU A OE1 1 ATOM 3646 O OE2 . GLU A 1 460 ? -35.453 -30.005 -14.280 1.00 32.70 ? 460 GLU A OE2 1 ATOM 3647 N N . GLU A 1 461 ? -37.407 -23.996 -16.809 1.00 29.91 ? 461 GLU A N 1 ATOM 3648 C CA . GLU A 1 461 ? -37.446 -22.903 -17.744 1.00 29.71 ? 461 GLU A CA 1 ATOM 3649 C C . GLU A 1 461 ? -36.693 -21.668 -17.241 1.00 29.88 ? 461 GLU A C 1 ATOM 3650 O O . GLU A 1 461 ? -35.937 -21.003 -17.976 1.00 29.97 ? 461 GLU A O 1 ATOM 3651 C CB . GLU A 1 461 ? -38.888 -22.474 -17.980 1.00 29.92 ? 461 GLU A CB 1 ATOM 3652 C CG . GLU A 1 461 ? -38.910 -21.301 -18.973 1.00 33.93 ? 461 GLU A CG 1 ATOM 3653 C CD . GLU A 1 461 ? -40.309 -20.740 -19.283 1.00 41.90 ? 461 GLU A CD 1 ATOM 3654 O OE1 . GLU A 1 461 ? -40.406 -19.902 -20.217 1.00 45.15 ? 461 GLU A OE1 1 ATOM 3655 O OE2 . GLU A 1 461 ? -41.294 -21.110 -18.612 1.00 40.95 ? 461 GLU A OE2 1 ATOM 3656 N N . ILE A 1 462 ? -36.972 -21.262 -16.008 1.00 29.70 ? 462 ILE A N 1 ATOM 3657 C CA . ILE A 1 462 ? -36.318 -20.059 -15.525 1.00 30.18 ? 462 ILE A CA 1 ATOM 3658 C C . ILE A 1 462 ? -34.777 -20.250 -15.419 1.00 29.12 ? 462 ILE A C 1 ATOM 3659 O O . ILE A 1 462 ? -33.982 -19.362 -15.798 1.00 30.12 ? 462 ILE A O 1 ATOM 3660 C CB . ILE A 1 462 ? -36.910 -19.648 -14.161 1.00 31.44 ? 462 ILE A CB 1 ATOM 3661 C CG1 . ILE A 1 462 ? -38.292 -19.034 -14.357 1.00 33.63 ? 462 ILE A CG1 1 ATOM 3662 C CG2 . ILE A 1 462 ? -36.015 -18.610 -13.464 1.00 33.65 ? 462 ILE A CG2 1 ATOM 3663 C CD1 . ILE A 1 462 ? -39.233 -19.413 -13.252 1.00 37.85 ? 462 ILE A CD1 1 ATOM 3664 N N . LEU A 1 463 ? -34.355 -21.415 -14.935 1.00 27.39 ? 463 LEU A N 1 ATOM 3665 C CA . LEU A 1 463 ? -32.897 -21.699 -14.805 1.00 27.17 ? 463 LEU A CA 1 ATOM 3666 C C . LEU A 1 463 ? -32.213 -21.641 -16.198 1.00 25.83 ? 463 LEU A C 1 ATOM 3667 O O . LEU A 1 463 ? -31.199 -20.967 -16.382 1.00 25.72 ? 463 LEU A O 1 ATOM 3668 C CB . LEU A 1 463 ? -32.619 -23.058 -14.166 1.00 25.90 ? 463 LEU A CB 1 ATOM 3669 C CG . LEU A 1 463 ? -31.128 -23.477 -14.113 1.00 27.46 ? 463 LEU A CG 1 ATOM 3670 C CD1 . LEU A 1 463 ? -30.293 -22.488 -13.225 1.00 25.00 ? 463 LEU A CD1 1 ATOM 3671 C CD2 . LEU A 1 463 ? -31.042 -24.896 -13.552 1.00 25.40 ? 463 LEU A CD2 1 ATOM 3672 N N . SER A 1 464 ? -32.817 -22.317 -17.170 1.00 24.47 ? 464 SER A N 1 ATOM 3673 C CA . SER A 1 464 ? -32.300 -22.336 -18.501 1.00 24.34 ? 464 SER A CA 1 ATOM 3674 C C . SER A 1 464 ? -32.263 -20.921 -19.070 1.00 24.53 ? 464 SER A C 1 ATOM 3675 O O . SER A 1 464 ? -31.299 -20.515 -19.689 1.00 24.70 ? 464 SER A O 1 ATOM 3676 C CB . SER A 1 464 ? -33.171 -23.253 -19.373 1.00 23.73 ? 464 SER A CB 1 ATOM 3677 O OG . SER A 1 464 ? -32.627 -23.361 -20.649 1.00 23.17 ? 464 SER A OG 1 ATOM 3678 N N . ARG A 1 465 ? -33.333 -20.170 -18.886 1.00 25.68 ? 465 ARG A N 1 ATOM 3679 C CA . ARG A 1 465 ? -33.375 -18.816 -19.466 1.00 26.63 ? 465 ARG A CA 1 ATOM 3680 C C . ARG A 1 465 ? -32.191 -18.011 -18.934 1.00 27.04 ? 465 ARG A C 1 ATOM 3681 O O . ARG A 1 465 ? -31.539 -17.238 -19.661 1.00 28.10 ? 465 ARG A O 1 ATOM 3682 C CB . ARG A 1 465 ? -34.698 -18.090 -19.076 1.00 25.20 ? 465 ARG A CB 1 ATOM 3683 C CG . ARG A 1 465 ? -34.788 -16.644 -19.578 1.00 28.28 ? 465 ARG A CG 1 ATOM 3684 C CD . ARG A 1 465 ? -34.866 -16.680 -21.087 1.00 30.87 ? 465 ARG A CD 1 ATOM 3685 N NE . ARG A 1 465 ? -34.596 -15.425 -21.824 1.00 35.70 ? 465 ARG A NE 1 ATOM 3686 C CZ . ARG A 1 465 ? -33.403 -15.058 -22.311 1.00 35.09 ? 465 ARG A CZ 1 ATOM 3687 N NH1 . ARG A 1 465 ? -32.307 -15.801 -22.093 1.00 29.83 ? 465 ARG A NH1 1 ATOM 3688 N NH2 . ARG A 1 465 ? -33.300 -13.926 -23.006 1.00 35.64 ? 465 ARG A NH2 1 ATOM 3689 N N . SER A 1 466 ? -31.938 -18.159 -17.636 1.00 27.56 ? 466 SER A N 1 ATOM 3690 C CA . SER A 1 466 ? -30.820 -17.436 -16.999 1.00 27.93 ? 466 SER A CA 1 ATOM 3691 C C . SER A 1 466 ? -29.426 -17.870 -17.542 1.00 26.42 ? 466 SER A C 1 ATOM 3692 O O . SER A 1 466 ? -28.554 -17.030 -17.903 1.00 25.63 ? 466 SER A O 1 ATOM 3693 C CB . SER A 1 466 ? -30.916 -17.627 -15.496 1.00 27.78 ? 466 SER A CB 1 ATOM 3694 O OG . SER A 1 466 ? -29.792 -17.020 -14.907 1.00 34.28 ? 466 SER A OG 1 ATOM 3695 N N . ILE A 1 467 ? -29.253 -19.189 -17.667 1.00 25.60 ? 467 ILE A N 1 ATOM 3696 C CA . ILE A 1 467 ? -27.993 -19.753 -18.163 1.00 23.87 ? 467 ILE A CA 1 ATOM 3697 C C . ILE A 1 467 ? -27.726 -19.283 -19.594 1.00 24.04 ? 467 ILE A C 1 ATOM 3698 O O . ILE A 1 467 ? -26.603 -18.855 -19.955 1.00 23.62 ? 467 ILE A O 1 ATOM 3699 C CB . ILE A 1 467 ? -28.019 -21.302 -18.089 1.00 24.05 ? 467 ILE A CB 1 ATOM 3700 C CG1 . ILE A 1 467 ? -27.854 -21.770 -16.604 1.00 22.51 ? 467 ILE A CG1 1 ATOM 3701 C CG2 . ILE A 1 467 ? -26.909 -21.915 -18.993 1.00 21.10 ? 467 ILE A CG2 1 ATOM 3702 C CD1 . ILE A 1 467 ? -28.191 -23.301 -16.393 1.00 12.29 ? 467 ILE A CD1 1 ATOM 3703 N N . VAL A 1 468 ? -28.768 -19.351 -20.417 1.00 23.47 ? 468 VAL A N 1 ATOM 3704 C CA . VAL A 1 468 ? -28.669 -18.835 -21.813 1.00 23.36 ? 468 VAL A CA 1 ATOM 3705 C C . VAL A 1 468 ? -28.256 -17.395 -21.860 1.00 22.85 ? 468 VAL A C 1 ATOM 3706 O O . VAL A 1 468 ? -27.439 -16.976 -22.701 1.00 24.25 ? 468 VAL A O 1 ATOM 3707 C CB . VAL A 1 468 ? -30.053 -19.049 -22.587 1.00 23.53 ? 468 VAL A CB 1 ATOM 3708 C CG1 . VAL A 1 468 ? -30.114 -18.199 -23.857 1.00 25.23 ? 468 VAL A CG1 1 ATOM 3709 C CG2 . VAL A 1 468 ? -30.283 -20.565 -22.877 1.00 20.76 ? 468 VAL A CG2 1 ATOM 3710 N N . LYS A 1 469 ? -28.820 -16.591 -20.965 1.00 22.84 ? 469 LYS A N 1 ATOM 3711 C CA . LYS A 1 469 ? -28.459 -15.150 -20.941 1.00 22.26 ? 469 LYS A CA 1 ATOM 3712 C C . LYS A 1 469 ? -27.011 -15.013 -20.517 1.00 22.56 ? 469 LYS A C 1 ATOM 3713 O O . LYS A 1 469 ? -26.207 -14.279 -21.145 1.00 22.71 ? 469 LYS A O 1 ATOM 3714 C CB . LYS A 1 469 ? -29.405 -14.391 -19.984 1.00 22.39 ? 469 LYS A CB 1 ATOM 3715 C CG . LYS A 1 469 ? -29.095 -12.940 -19.821 1.00 21.70 ? 469 LYS A CG 1 ATOM 3716 C CD . LYS A 1 469 ? -28.835 -12.261 -21.155 1.00 22.22 ? 469 LYS A CD 1 ATOM 3717 C CE . LYS A 1 469 ? -30.223 -11.969 -21.824 1.00 26.13 ? 469 LYS A CE 1 ATOM 3718 N NZ . LYS A 1 469 ? -30.024 -11.117 -23.021 1.00 22.26 ? 469 LYS A NZ 1 ATOM 3719 N N . ARG A 1 470 ? -26.635 -15.752 -19.463 1.00 22.66 ? 470 ARG A N 1 ATOM 3720 C CA . ARG A 1 470 ? -25.260 -15.648 -18.961 1.00 21.38 ? 470 ARG A CA 1 ATOM 3721 C C . ARG A 1 470 ? -24.221 -16.089 -20.064 1.00 21.80 ? 470 ARG A C 1 ATOM 3722 O O . ARG A 1 470 ? -23.230 -15.421 -20.267 1.00 21.12 ? 470 ARG A O 1 ATOM 3723 C CB . ARG A 1 470 ? -25.087 -16.444 -17.639 1.00 21.77 ? 470 ARG A CB 1 ATOM 3724 C CG . ARG A 1 470 ? -25.740 -15.826 -16.387 1.00 20.04 ? 470 ARG A CG 1 ATOM 3725 C CD . ARG A 1 470 ? -25.397 -16.698 -15.155 1.00 21.41 ? 470 ARG A CD 1 ATOM 3726 N NE . ARG A 1 470 ? -26.168 -16.369 -13.944 1.00 22.45 ? 470 ARG A NE 1 ATOM 3727 C CZ . ARG A 1 470 ? -25.862 -15.360 -13.123 1.00 21.43 ? 470 ARG A CZ 1 ATOM 3728 N NH1 . ARG A 1 470 ? -26.561 -15.102 -12.022 1.00 26.07 ? 470 ARG A NH1 1 ATOM 3729 N NH2 . ARG A 1 470 ? -24.841 -14.615 -13.401 1.00 19.99 ? 470 ARG A NH2 1 ATOM 3730 N N . TRP A 1 471 ? -24.464 -17.219 -20.754 1.00 21.15 ? 471 TRP A N 1 ATOM 3731 C CA . TRP A 1 471 ? -23.594 -17.670 -21.838 1.00 19.78 ? 471 TRP A CA 1 ATOM 3732 C C . TRP A 1 471 ? -23.522 -16.686 -22.971 1.00 20.00 ? 471 TRP A C 1 ATOM 3733 O O . TRP A 1 471 ? -22.451 -16.429 -23.540 1.00 19.58 ? 471 TRP A O 1 ATOM 3734 C CB . TRP A 1 471 ? -24.106 -19.029 -22.372 1.00 19.78 ? 471 TRP A CB 1 ATOM 3735 C CG . TRP A 1 471 ? -23.453 -20.333 -21.753 1.00 20.65 ? 471 TRP A CG 1 ATOM 3736 C CD1 . TRP A 1 471 ? -22.919 -21.386 -22.457 1.00 18.66 ? 471 TRP A CD1 1 ATOM 3737 C CD2 . TRP A 1 471 ? -23.281 -20.669 -20.343 1.00 21.13 ? 471 TRP A CD2 1 ATOM 3738 N NE1 . TRP A 1 471 ? -22.431 -22.350 -21.577 1.00 20.05 ? 471 TRP A NE1 1 ATOM 3739 C CE2 . TRP A 1 471 ? -22.638 -21.935 -20.285 1.00 22.32 ? 471 TRP A CE2 1 ATOM 3740 C CE3 . TRP A 1 471 ? -23.629 -20.037 -19.141 1.00 21.98 ? 471 TRP A CE3 1 ATOM 3741 C CZ2 . TRP A 1 471 ? -22.343 -22.585 -19.069 1.00 19.71 ? 471 TRP A CZ2 1 ATOM 3742 C CZ3 . TRP A 1 471 ? -23.307 -20.676 -17.912 1.00 22.74 ? 471 TRP A CZ3 1 ATOM 3743 C CH2 . TRP A 1 471 ? -22.709 -21.952 -17.891 1.00 22.38 ? 471 TRP A CH2 1 ATOM 3744 N N . ALA A 1 472 ? -24.691 -16.136 -23.343 1.00 20.73 ? 472 ALA A N 1 ATOM 3745 C CA . ALA A 1 472 ? -24.749 -15.117 -24.380 1.00 21.24 ? 472 ALA A CA 1 ATOM 3746 C C . ALA A 1 472 ? -24.030 -13.817 -23.979 1.00 20.78 ? 472 ALA A C 1 ATOM 3747 O O . ALA A 1 472 ? -23.274 -13.224 -24.763 1.00 20.13 ? 472 ALA A O 1 ATOM 3748 C CB . ALA A 1 472 ? -26.220 -14.825 -24.737 1.00 22.50 ? 472 ALA A CB 1 ATOM 3749 N N . ASN A 1 473 ? -24.248 -13.351 -22.766 1.00 20.74 ? 473 ASN A N 1 ATOM 3750 C CA . ASN A 1 473 ? -23.483 -12.148 -22.378 1.00 20.71 ? 473 ASN A CA 1 ATOM 3751 C C . ASN A 1 473 ? -22.024 -12.452 -22.336 1.00 20.67 ? 473 ASN A C 1 ATOM 3752 O O . ASN A 1 473 ? -21.204 -11.593 -22.705 1.00 21.35 ? 473 ASN A O 1 ATOM 3753 C CB . ASN A 1 473 ? -23.932 -11.570 -21.045 1.00 21.81 ? 473 ASN A CB 1 ATOM 3754 C CG . ASN A 1 473 ? -25.243 -10.774 -21.154 1.00 25.50 ? 473 ASN A CG 1 ATOM 3755 O OD1 . ASN A 1 473 ? -25.677 -10.388 -22.268 1.00 26.85 ? 473 ASN A OD1 1 ATOM 3756 N ND2 . ASN A 1 473 ? -25.905 -10.568 -20.004 1.00 24.54 ? 473 ASN A ND2 1 ATOM 3757 N N . PHE A 1 474 ? -21.648 -13.664 -21.884 1.00 20.65 ? 474 PHE A N 1 ATOM 3758 C CA . PHE A 1 474 ? -20.222 -13.998 -21.946 1.00 19.97 ? 474 PHE A CA 1 ATOM 3759 C C . PHE A 1 474 ? -19.713 -13.884 -23.386 1.00 21.02 ? 474 PHE A C 1 ATOM 3760 O O . PHE A 1 474 ? -18.690 -13.294 -23.662 1.00 21.29 ? 474 PHE A O 1 ATOM 3761 C CB . PHE A 1 474 ? -19.942 -15.425 -21.487 1.00 19.63 ? 474 PHE A CB 1 ATOM 3762 C CG . PHE A 1 474 ? -18.473 -15.762 -21.560 1.00 20.34 ? 474 PHE A CG 1 ATOM 3763 C CD1 . PHE A 1 474 ? -17.580 -15.203 -20.621 1.00 13.25 ? 474 PHE A CD1 1 ATOM 3764 C CD2 . PHE A 1 474 ? -17.983 -16.617 -22.546 1.00 15.11 ? 474 PHE A CD2 1 ATOM 3765 C CE1 . PHE A 1 474 ? -16.247 -15.451 -20.709 1.00 16.41 ? 474 PHE A CE1 1 ATOM 3766 C CE2 . PHE A 1 474 ? -16.634 -16.884 -22.631 1.00 13.88 ? 474 PHE A CE2 1 ATOM 3767 C CZ . PHE A 1 474 ? -15.766 -16.306 -21.722 1.00 15.55 ? 474 PHE A CZ 1 ATOM 3768 N N . ALA A 1 475 ? -20.409 -14.529 -24.325 1.00 22.06 ? 475 ALA A N 1 ATOM 3769 C CA . ALA A 1 475 ? -19.937 -14.484 -25.695 1.00 21.81 ? 475 ALA A CA 1 ATOM 3770 C C . ALA A 1 475 ? -19.902 -13.037 -26.225 1.00 22.75 ? 475 ALA A C 1 ATOM 3771 O O . ALA A 1 475 ? -18.949 -12.633 -26.874 1.00 23.48 ? 475 ALA A O 1 ATOM 3772 C CB . ALA A 1 475 ? -20.856 -15.360 -26.601 1.00 20.03 ? 475 ALA A CB 1 ATOM 3773 N N . LYS A 1 476 ? -20.970 -12.283 -26.041 1.00 23.43 ? 476 LYS A N 1 ATOM 3774 C CA . LYS A 1 476 ? -21.009 -10.916 -26.627 1.00 25.59 ? 476 LYS A CA 1 ATOM 3775 C C . LYS A 1 476 ? -20.056 -9.951 -25.885 1.00 25.42 ? 476 LYS A C 1 ATOM 3776 O O . LYS A 1 476 ? -19.460 -9.090 -26.506 1.00 24.72 ? 476 LYS A O 1 ATOM 3777 C CB . LYS A 1 476 ? -22.434 -10.322 -26.600 1.00 25.60 ? 476 LYS A CB 1 ATOM 3778 C CG . LYS A 1 476 ? -23.512 -11.052 -27.423 1.00 26.72 ? 476 LYS A CG 1 ATOM 3779 C CD . LYS A 1 476 ? -24.920 -10.618 -27.001 1.00 26.91 ? 476 LYS A CD 1 ATOM 3780 C CE . LYS A 1 476 ? -25.938 -11.234 -27.964 1.00 32.69 ? 476 LYS A CE 1 ATOM 3781 N NZ . LYS A 1 476 ? -27.315 -11.319 -27.319 1.00 34.43 ? 476 LYS A NZ 1 ATOM 3782 N N . TYR A 1 477 ? -19.886 -10.114 -24.575 1.00 25.14 ? 477 TYR A N 1 ATOM 3783 C CA . TYR A 1 477 ? -19.249 -9.033 -23.805 1.00 26.87 ? 477 TYR A CA 1 ATOM 3784 C C . TYR A 1 477 ? -18.144 -9.493 -22.852 1.00 27.18 ? 477 TYR A C 1 ATOM 3785 O O . TYR A 1 477 ? -17.549 -8.659 -22.169 1.00 27.94 ? 477 TYR A O 1 ATOM 3786 C CB . TYR A 1 477 ? -20.305 -8.300 -22.964 1.00 26.11 ? 477 TYR A CB 1 ATOM 3787 C CG . TYR A 1 477 ? -21.557 -7.951 -23.735 1.00 28.30 ? 477 TYR A CG 1 ATOM 3788 C CD1 . TYR A 1 477 ? -22.840 -8.319 -23.280 1.00 28.84 ? 477 TYR A CD1 1 ATOM 3789 C CD2 . TYR A 1 477 ? -21.465 -7.232 -24.905 1.00 28.21 ? 477 TYR A CD2 1 ATOM 3790 C CE1 . TYR A 1 477 ? -23.975 -7.985 -24.028 1.00 28.08 ? 477 TYR A CE1 1 ATOM 3791 C CE2 . TYR A 1 477 ? -22.598 -6.892 -25.631 1.00 30.53 ? 477 TYR A CE2 1 ATOM 3792 C CZ . TYR A 1 477 ? -23.834 -7.266 -25.194 1.00 30.55 ? 477 TYR A CZ 1 ATOM 3793 O OH . TYR A 1 477 ? -24.918 -6.888 -25.967 1.00 30.74 ? 477 TYR A OH 1 ATOM 3794 N N . GLY A 1 478 ? -17.923 -10.802 -22.776 1.00 26.64 ? 478 GLY A N 1 ATOM 3795 C CA . GLY A 1 478 ? -16.839 -11.368 -22.014 1.00 26.11 ? 478 GLY A CA 1 ATOM 3796 C C . GLY A 1 478 ? -17.153 -11.449 -20.525 1.00 26.44 ? 478 GLY A C 1 ATOM 3797 O O . GLY A 1 478 ? -16.243 -11.657 -19.709 1.00 26.23 ? 478 GLY A O 1 ATOM 3798 N N . ASN A 1 479 ? -18.433 -11.366 -20.185 1.00 25.14 ? 479 ASN A N 1 ATOM 3799 C CA . ASN A 1 479 ? -18.872 -11.261 -18.819 1.00 25.57 ? 479 ASN A CA 1 ATOM 3800 C C . ASN A 1 479 ? -20.191 -11.963 -18.569 1.00 24.96 ? 479 ASN A C 1 ATOM 3801 O O . ASN A 1 479 ? -21.206 -11.475 -19.019 1.00 27.03 ? 479 ASN A O 1 ATOM 3802 C CB . ASN A 1 479 ? -19.067 -9.784 -18.540 1.00 26.02 ? 479 ASN A CB 1 ATOM 3803 C CG . ASN A 1 479 ? -18.770 -9.416 -17.104 1.00 27.42 ? 479 ASN A CG 1 ATOM 3804 O OD1 . ASN A 1 479 ? -18.967 -10.213 -16.194 1.00 28.87 ? 479 ASN A OD1 1 ATOM 3805 N ND2 . ASN A 1 479 ? -18.335 -8.184 -16.898 1.00 31.73 ? 479 ASN A ND2 1 ATOM 3806 N N . PRO A 1 480 ? -20.208 -13.092 -17.829 1.00 23.53 ? 480 PRO A N 1 ATOM 3807 C CA . PRO A 1 480 ? -21.419 -13.920 -17.827 1.00 23.53 ? 480 PRO A CA 1 ATOM 3808 C C . PRO A 1 480 ? -22.456 -13.478 -16.806 1.00 24.66 ? 480 PRO A C 1 ATOM 3809 O O . PRO A 1 480 ? -22.869 -14.269 -15.939 1.00 24.68 ? 480 PRO A O 1 ATOM 3810 C CB . PRO A 1 480 ? -20.886 -15.322 -17.462 1.00 23.62 ? 480 PRO A CB 1 ATOM 3811 C CG . PRO A 1 480 ? -19.654 -15.028 -16.602 1.00 22.55 ? 480 PRO A CG 1 ATOM 3812 C CD . PRO A 1 480 ? -19.081 -13.730 -17.122 1.00 23.57 ? 480 PRO A CD 1 ATOM 3813 N N . GLN A 1 481 ? -22.854 -12.213 -16.858 1.00 24.35 ? 481 GLN A N 1 ATOM 3814 C CA . GLN A 1 481 ? -23.775 -11.682 -15.853 1.00 23.78 ? 481 GLN A CA 1 ATOM 3815 C C . GLN A 1 481 ? -25.173 -11.829 -16.412 1.00 25.93 ? 481 GLN A C 1 ATOM 3816 O O . GLN A 1 481 ? -25.334 -11.883 -17.631 1.00 25.92 ? 481 GLN A O 1 ATOM 3817 C CB . GLN A 1 481 ? -23.468 -10.199 -15.553 1.00 21.03 ? 481 GLN A CB 1 ATOM 3818 C CG . GLN A 1 481 ? -21.995 -9.907 -15.166 1.00 21.10 ? 481 GLN A CG 1 ATOM 3819 C CD . GLN A 1 481 ? -21.510 -10.775 -14.008 1.00 23.23 ? 481 GLN A CD 1 ATOM 3820 O OE1 . GLN A 1 481 ? -22.321 -11.240 -13.197 1.00 22.14 ? 481 GLN A OE1 1 ATOM 3821 N NE2 . GLN A 1 481 ? -20.190 -11.017 -13.929 1.00 20.51 ? 481 GLN A NE2 1 ATOM 3822 N N . GLU A 1 482 ? -26.175 -11.943 -15.530 1.00 27.38 ? 482 GLU A N 1 ATOM 3823 C CA . GLU A 1 482 ? -27.573 -11.727 -15.903 1.00 29.38 ? 482 GLU A CA 1 ATOM 3824 C C . GLU A 1 482 ? -27.939 -10.399 -15.201 1.00 30.89 ? 482 GLU A C 1 ATOM 3825 O O . GLU A 1 482 ? -28.113 -10.370 -13.951 1.00 31.30 ? 482 GLU A O 1 ATOM 3826 C CB . GLU A 1 482 ? -28.445 -12.891 -15.434 1.00 29.28 ? 482 GLU A CB 1 ATOM 3827 C CG . GLU A 1 482 ? -29.872 -12.898 -15.977 1.00 33.98 ? 482 GLU A CG 1 ATOM 3828 C CD . GLU A 1 482 ? -30.657 -11.653 -15.545 1.00 36.56 ? 482 GLU A CD 1 ATOM 3829 O OE1 . GLU A 1 482 ? -31.113 -10.875 -16.402 1.00 36.14 ? 482 GLU A OE1 1 ATOM 3830 O OE2 . GLU A 1 482 ? -30.748 -11.416 -14.335 1.00 40.16 ? 482 GLU A OE2 1 ATOM 3831 N N . THR A 1 483 ? -27.962 -9.288 -15.957 1.00 30.13 ? 483 THR A N 1 ATOM 3832 C CA . THR A 1 483 ? -27.961 -7.969 -15.308 1.00 31.32 ? 483 THR A CA 1 ATOM 3833 C C . THR A 1 483 ? -29.368 -7.439 -14.894 1.00 32.63 ? 483 THR A C 1 ATOM 3834 O O . THR A 1 483 ? -29.463 -6.443 -14.175 1.00 32.70 ? 483 THR A O 1 ATOM 3835 C CB . THR A 1 483 ? -27.316 -6.888 -16.210 1.00 30.77 ? 483 THR A CB 1 ATOM 3836 O OG1 . THR A 1 483 ? -28.030 -6.855 -17.460 1.00 29.90 ? 483 THR A OG1 1 ATOM 3837 C CG2 . THR A 1 483 ? -25.865 -7.201 -16.475 1.00 29.70 ? 483 THR A CG2 1 ATOM 3838 N N . GLN A 1 484 ? -30.443 -8.075 -15.350 1.00 33.44 ? 484 GLN A N 1 ATOM 3839 C CA . GLN A 1 484 ? -31.774 -7.490 -15.223 1.00 35.32 ? 484 GLN A CA 1 ATOM 3840 C C . GLN A 1 484 ? -32.651 -7.987 -14.088 1.00 37.04 ? 484 GLN A C 1 ATOM 3841 O O . GLN A 1 484 ? -33.564 -7.302 -13.675 1.00 37.58 ? 484 GLN A O 1 ATOM 3842 C CB . GLN A 1 484 ? -32.527 -7.648 -16.553 1.00 34.99 ? 484 GLN A CB 1 ATOM 3843 C CG . GLN A 1 484 ? -31.873 -6.830 -17.657 1.00 35.44 ? 484 GLN A CG 1 ATOM 3844 C CD . GLN A 1 484 ? -32.454 -7.060 -19.045 1.00 39.02 ? 484 GLN A CD 1 ATOM 3845 O OE1 . GLN A 1 484 ? -32.737 -8.202 -19.454 1.00 41.16 ? 484 GLN A OE1 1 ATOM 3846 N NE2 . GLN A 1 484 ? -32.601 -5.967 -19.804 1.00 38.30 ? 484 GLN A NE2 1 ATOM 3847 N N . ASN A 1 485 ? -32.435 -9.194 -13.610 1.00 39.08 ? 485 ASN A N 1 ATOM 3848 C CA . ASN A 1 485 ? -33.398 -9.744 -12.687 1.00 41.49 ? 485 ASN A CA 1 ATOM 3849 C C . ASN A 1 485 ? -32.808 -9.896 -11.291 1.00 42.88 ? 485 ASN A C 1 ATOM 3850 O O . ASN A 1 485 ? -32.961 -10.942 -10.658 1.00 43.96 ? 485 ASN A O 1 ATOM 3851 C CB . ASN A 1 485 ? -33.939 -11.086 -13.215 1.00 41.61 ? 485 ASN A CB 1 ATOM 3852 C CG . ASN A 1 485 ? -34.807 -10.948 -14.521 1.00 46.76 ? 485 ASN A CG 1 ATOM 3853 O OD1 . ASN A 1 485 ? -35.183 -9.853 -14.958 1.00 45.64 ? 485 ASN A OD1 1 ATOM 3854 N ND2 . ASN A 1 485 ? -35.098 -12.097 -15.145 1.00 55.90 ? 485 ASN A ND2 1 ATOM 3855 N N . ASN A 1 486 ? -32.135 -8.857 -10.798 1.00 44.08 ? 486 ASN A N 1 ATOM 3856 C CA . ASN A 1 486 ? -31.493 -8.928 -9.484 1.00 45.56 ? 486 ASN A CA 1 ATOM 3857 C C . ASN A 1 486 ? -30.824 -10.296 -9.279 1.00 44.78 ? 486 ASN A C 1 ATOM 3858 O O . ASN A 1 486 ? -31.108 -11.001 -8.292 1.00 45.67 ? 486 ASN A O 1 ATOM 3859 C CB . ASN A 1 486 ? -32.500 -8.693 -8.311 1.00 46.61 ? 486 ASN A CB 1 ATOM 3860 C CG . ASN A 1 486 ? -33.606 -7.676 -8.653 1.00 52.08 ? 486 ASN A CG 1 ATOM 3861 O OD1 . ASN A 1 486 ? -33.343 -6.457 -8.810 1.00 57.11 ? 486 ASN A OD1 1 ATOM 3862 N ND2 . ASN A 1 486 ? -34.860 -8.170 -8.764 1.00 54.54 ? 486 ASN A ND2 1 ATOM 3863 N N . SER A 1 487 ? -29.951 -10.680 -10.196 1.00 42.78 ? 487 SER A N 1 ATOM 3864 C CA . SER A 1 487 ? -29.315 -11.975 -10.103 1.00 40.94 ? 487 SER A CA 1 ATOM 3865 C C . SER A 1 487 ? -28.030 -11.891 -9.306 1.00 40.04 ? 487 SER A C 1 ATOM 3866 O O . SER A 1 487 ? -27.480 -10.814 -9.115 1.00 40.15 ? 487 SER A O 1 ATOM 3867 C CB . SER A 1 487 ? -29.028 -12.535 -11.491 1.00 40.93 ? 487 SER A CB 1 ATOM 3868 O OG . SER A 1 487 ? -30.239 -12.828 -12.151 1.00 39.95 ? 487 SER A OG 1 ATOM 3869 N N . THR A 1 488 ? -27.565 -13.033 -8.818 1.00 38.63 ? 488 THR A N 1 ATOM 3870 C CA . THR A 1 488 ? -26.281 -13.073 -8.172 1.00 36.36 ? 488 THR A CA 1 ATOM 3871 C C . THR A 1 488 ? -25.256 -12.722 -9.234 1.00 35.86 ? 488 THR A C 1 ATOM 3872 O O . THR A 1 488 ? -25.315 -13.176 -10.370 1.00 35.80 ? 488 THR A O 1 ATOM 3873 C CB . THR A 1 488 ? -25.958 -14.448 -7.592 1.00 36.72 ? 488 THR A CB 1 ATOM 3874 O OG1 . THR A 1 488 ? -26.914 -14.761 -6.572 1.00 35.86 ? 488 THR A OG1 1 ATOM 3875 C CG2 . THR A 1 488 ? -24.556 -14.440 -6.975 1.00 35.11 ? 488 THR A CG2 1 ATOM 3876 N N . SER A 1 489 ? -24.322 -11.886 -8.835 1.00 34.82 ? 489 SER A N 1 ATOM 3877 C CA . SER A 1 489 ? -23.284 -11.397 -9.680 1.00 34.88 ? 489 SER A CA 1 ATOM 3878 C C . SER A 1 489 ? -22.211 -12.518 -9.727 1.00 33.69 ? 489 SER A C 1 ATOM 3879 O O . SER A 1 489 ? -21.949 -13.160 -8.719 1.00 33.56 ? 489 SER A O 1 ATOM 3880 C CB . SER A 1 489 ? -22.798 -10.121 -9.009 1.00 35.81 ? 489 SER A CB 1 ATOM 3881 O OG . SER A 1 489 ? -21.745 -9.568 -9.731 1.00 40.95 ? 489 SER A OG 1 ATOM 3882 N N . TRP A 1 490 ? -21.668 -12.829 -10.903 1.00 30.48 ? 490 TRP A N 1 ATOM 3883 C CA . TRP A 1 490 ? -20.741 -13.936 -11.020 1.00 27.63 ? 490 TRP A CA 1 ATOM 3884 C C . TRP A 1 490 ? -19.325 -13.367 -10.919 1.00 26.10 ? 490 TRP A C 1 ATOM 3885 O O . TRP A 1 490 ? -18.935 -12.677 -11.825 1.00 26.00 ? 490 TRP A O 1 ATOM 3886 C CB . TRP A 1 490 ? -20.946 -14.600 -12.406 1.00 26.87 ? 490 TRP A CB 1 ATOM 3887 C CG . TRP A 1 490 ? -20.247 -15.900 -12.593 1.00 25.45 ? 490 TRP A CG 1 ATOM 3888 C CD1 . TRP A 1 490 ? -19.159 -16.379 -11.882 1.00 21.78 ? 490 TRP A CD1 1 ATOM 3889 C CD2 . TRP A 1 490 ? -20.588 -16.929 -13.544 1.00 21.72 ? 490 TRP A CD2 1 ATOM 3890 N NE1 . TRP A 1 490 ? -18.811 -17.630 -12.338 1.00 19.11 ? 490 TRP A NE1 1 ATOM 3891 C CE2 . TRP A 1 490 ? -19.662 -17.983 -13.368 1.00 21.38 ? 490 TRP A CE2 1 ATOM 3892 C CE3 . TRP A 1 490 ? -21.579 -17.050 -14.531 1.00 20.78 ? 490 TRP A CE3 1 ATOM 3893 C CZ2 . TRP A 1 490 ? -19.711 -19.166 -14.141 1.00 19.24 ? 490 TRP A CZ2 1 ATOM 3894 C CZ3 . TRP A 1 490 ? -21.641 -18.249 -15.306 1.00 19.96 ? 490 TRP A CZ3 1 ATOM 3895 C CH2 . TRP A 1 490 ? -20.687 -19.246 -15.139 1.00 21.13 ? 490 TRP A CH2 1 ATOM 3896 N N . PRO A 1 491 ? -18.553 -13.645 -9.817 1.00 25.32 ? 491 PRO A N 1 ATOM 3897 C CA . PRO A 1 491 ? -17.208 -13.068 -9.657 1.00 23.96 ? 491 PRO A CA 1 ATOM 3898 C C . PRO A 1 491 ? -16.182 -13.776 -10.509 1.00 23.97 ? 491 PRO A C 1 ATOM 3899 O O . PRO A 1 491 ? -16.350 -14.964 -10.788 1.00 22.83 ? 491 PRO A O 1 ATOM 3900 C CB . PRO A 1 491 ? -16.861 -13.414 -8.211 1.00 25.20 ? 491 PRO A CB 1 ATOM 3901 C CG . PRO A 1 491 ? -17.478 -14.690 -7.998 1.00 23.68 ? 491 PRO A CG 1 ATOM 3902 C CD . PRO A 1 491 ? -18.859 -14.555 -8.692 1.00 24.88 ? 491 PRO A CD 1 ATOM 3903 N N . VAL A 1 492 ? -15.112 -13.082 -10.909 1.00 23.80 ? 492 VAL A N 1 ATOM 3904 C CA . VAL A 1 492 ? -14.048 -13.787 -11.552 1.00 23.76 ? 492 VAL A CA 1 ATOM 3905 C C . VAL A 1 492 ? -13.358 -14.743 -10.577 1.00 25.24 ? 492 VAL A C 1 ATOM 3906 O O . VAL A 1 492 ? -13.300 -14.542 -9.320 1.00 22.98 ? 492 VAL A O 1 ATOM 3907 C CB . VAL A 1 492 ? -13.036 -12.868 -12.215 1.00 25.01 ? 492 VAL A CB 1 ATOM 3908 C CG1 . VAL A 1 492 ? -13.738 -11.774 -13.049 1.00 23.43 ? 492 VAL A CG1 1 ATOM 3909 C CG2 . VAL A 1 492 ? -12.217 -12.289 -11.180 1.00 25.70 ? 492 VAL A CG2 1 ATOM 3910 N N . PHE A 1 493 ? -12.811 -15.779 -11.183 1.00 24.25 ? 493 PHE A N 1 ATOM 3911 C CA . PHE A 1 493 ? -12.083 -16.799 -10.482 1.00 25.10 ? 493 PHE A CA 1 ATOM 3912 C C . PHE A 1 493 ? -10.636 -16.407 -10.510 1.00 27.33 ? 493 PHE A C 1 ATOM 3913 O O . PHE A 1 493 ? -10.101 -16.134 -11.587 1.00 26.99 ? 493 PHE A O 1 ATOM 3914 C CB . PHE A 1 493 ? -12.282 -18.134 -11.233 1.00 24.26 ? 493 PHE A CB 1 ATOM 3915 C CG . PHE A 1 493 ? -11.572 -19.292 -10.629 1.00 22.86 ? 493 PHE A CG 1 ATOM 3916 C CD1 . PHE A 1 493 ? -10.223 -19.490 -10.881 1.00 23.34 ? 493 PHE A CD1 1 ATOM 3917 C CD2 . PHE A 1 493 ? -12.269 -20.226 -9.858 1.00 21.64 ? 493 PHE A CD2 1 ATOM 3918 C CE1 . PHE A 1 493 ? -9.518 -20.594 -10.302 1.00 23.04 ? 493 PHE A CE1 1 ATOM 3919 C CE2 . PHE A 1 493 ? -11.622 -21.349 -9.339 1.00 19.87 ? 493 PHE A CE2 1 ATOM 3920 C CZ . PHE A 1 493 ? -10.231 -21.519 -9.556 1.00 21.76 ? 493 PHE A CZ 1 ATOM 3921 N N . LYS A 1 494 ? -10.020 -16.349 -9.329 1.00 29.06 ? 494 LYS A N 1 ATOM 3922 C CA . LYS A 1 494 ? -8.614 -15.958 -9.177 1.00 32.72 ? 494 LYS A CA 1 ATOM 3923 C C . LYS A 1 494 ? -7.927 -17.082 -8.415 1.00 33.06 ? 494 LYS A C 1 ATOM 3924 O O . LYS A 1 494 ? -8.573 -17.735 -7.604 1.00 31.68 ? 494 LYS A O 1 ATOM 3925 C CB . LYS A 1 494 ? -8.523 -14.677 -8.318 1.00 33.98 ? 494 LYS A CB 1 ATOM 3926 C CG . LYS A 1 494 ? -8.933 -13.351 -8.970 1.00 38.94 ? 494 LYS A CG 1 ATOM 3927 C CD . LYS A 1 494 ? -8.149 -13.100 -10.297 1.00 46.02 ? 494 LYS A CD 1 ATOM 3928 C CE . LYS A 1 494 ? -8.675 -11.848 -11.075 1.00 51.02 ? 494 LYS A CE 1 ATOM 3929 N NZ . LYS A 1 494 ? -8.446 -11.923 -12.600 1.00 49.39 ? 494 LYS A NZ 1 ATOM 3930 N N . SER A 1 495 ? -6.654 -17.365 -8.676 1.00 35.38 ? 495 SER A N 1 ATOM 3931 C CA . SER A 1 495 ? -5.882 -18.145 -7.686 1.00 37.80 ? 495 SER A CA 1 ATOM 3932 C C . SER A 1 495 ? -5.987 -17.267 -6.464 1.00 38.75 ? 495 SER A C 1 ATOM 3933 O O . SER A 1 495 ? -6.148 -16.049 -6.550 1.00 40.66 ? 495 SER A O 1 ATOM 3934 C CB . SER A 1 495 ? -4.380 -18.239 -8.004 1.00 39.23 ? 495 SER A CB 1 ATOM 3935 O OG . SER A 1 495 ? -4.101 -19.049 -9.145 1.00 43.77 ? 495 SER A OG 1 ATOM 3936 N N . THR A 1 496 ? -5.836 -17.861 -5.315 1.00 38.95 ? 496 THR A N 1 ATOM 3937 C CA . THR A 1 496 ? -6.130 -17.170 -4.089 1.00 39.76 ? 496 THR A CA 1 ATOM 3938 C C . THR A 1 496 ? -7.561 -17.487 -3.707 1.00 37.73 ? 496 THR A C 1 ATOM 3939 O O . THR A 1 496 ? -7.778 -18.520 -3.062 1.00 37.76 ? 496 THR A O 1 ATOM 3940 C CB . THR A 1 496 ? -5.678 -15.644 -4.026 1.00 40.70 ? 496 THR A CB 1 ATOM 3941 O OG1 . THR A 1 496 ? -6.463 -14.797 -4.910 1.00 44.97 ? 496 THR A OG1 1 ATOM 3942 C CG2 . THR A 1 496 ? -4.164 -15.542 -4.350 1.00 41.48 ? 496 THR A CG2 1 ATOM 3943 N N . GLU A 1 497 ? -8.547 -16.710 -4.120 1.00 35.64 ? 497 GLU A N 1 ATOM 3944 C CA . GLU A 1 497 ? -9.897 -17.008 -3.593 1.00 34.92 ? 497 GLU A CA 1 ATOM 3945 C C . GLU A 1 497 ? -10.629 -18.138 -4.257 1.00 32.11 ? 497 GLU A C 1 ATOM 3946 O O . GLU A 1 497 ? -11.426 -18.831 -3.611 1.00 32.09 ? 497 GLU A O 1 ATOM 3947 C CB . GLU A 1 497 ? -10.767 -15.790 -3.644 1.00 35.28 ? 497 GLU A CB 1 ATOM 3948 C CG . GLU A 1 497 ? -9.950 -14.542 -3.535 1.00 42.37 ? 497 GLU A CG 1 ATOM 3949 C CD . GLU A 1 497 ? -10.737 -13.364 -4.084 1.00 52.23 ? 497 GLU A CD 1 ATOM 3950 O OE1 . GLU A 1 497 ? -10.978 -12.473 -3.212 1.00 53.68 ? 497 GLU A OE1 1 ATOM 3951 O OE2 . GLU A 1 497 ? -11.154 -13.380 -5.326 1.00 49.60 ? 497 GLU A OE2 1 ATOM 3952 N N . GLN A 1 498 ? -10.402 -18.308 -5.543 1.00 28.91 ? 498 GLN A N 1 ATOM 3953 C CA . GLN A 1 498 ? -11.067 -19.390 -6.250 1.00 27.16 ? 498 GLN A CA 1 ATOM 3954 C C . GLN A 1 498 ? -12.589 -19.390 -6.017 1.00 24.88 ? 498 GLN A C 1 ATOM 3955 O O . GLN A 1 498 ? -13.171 -20.410 -5.621 1.00 24.80 ? 498 GLN A O 1 ATOM 3956 C CB . GLN A 1 498 ? -10.437 -20.702 -5.791 1.00 28.33 ? 498 GLN A CB 1 ATOM 3957 C CG . GLN A 1 498 ? -8.946 -20.761 -5.990 1.00 29.14 ? 498 GLN A CG 1 ATOM 3958 C CD . GLN A 1 498 ? -8.269 -21.805 -5.068 1.00 34.72 ? 498 GLN A CD 1 ATOM 3959 O OE1 . GLN A 1 498 ? -7.383 -21.465 -4.272 1.00 40.69 ? 498 GLN A OE1 1 ATOM 3960 N NE2 . GLN A 1 498 ? -8.712 -23.031 -5.131 1.00 22.99 ? 498 GLN A NE2 1 ATOM 3961 N N . LYS A 1 499 ? -13.222 -18.251 -6.282 1.00 22.48 ? 499 LYS A N 1 ATOM 3962 C CA . LYS A 1 499 ? -14.686 -18.085 -6.196 1.00 22.33 ? 499 LYS A CA 1 ATOM 3963 C C . LYS A 1 499 ? -15.365 -18.743 -7.401 1.00 21.51 ? 499 LYS A C 1 ATOM 3964 O O . LYS A 1 499 ? -14.843 -18.694 -8.514 1.00 20.96 ? 499 LYS A O 1 ATOM 3965 C CB . LYS A 1 499 ? -15.082 -16.596 -6.124 1.00 20.98 ? 499 LYS A CB 1 ATOM 3966 C CG . LYS A 1 499 ? -14.683 -15.911 -4.790 1.00 24.48 ? 499 LYS A CG 1 ATOM 3967 C CD . LYS A 1 499 ? -15.127 -14.460 -4.721 1.00 26.14 ? 499 LYS A CD 1 ATOM 3968 C CE . LYS A 1 499 ? -14.461 -13.741 -3.507 1.00 29.05 ? 499 LYS A CE 1 ATOM 3969 N NZ . LYS A 1 499 ? -14.817 -12.305 -3.585 1.00 27.20 ? 499 LYS A NZ 1 ATOM 3970 N N . TYR A 1 500 ? -16.513 -19.370 -7.153 1.00 21.41 ? 500 TYR A N 1 ATOM 3971 C CA . TYR A 1 500 ? -17.298 -19.996 -8.254 1.00 21.65 ? 500 TYR A CA 1 ATOM 3972 C C . TYR A 1 500 ? -18.763 -19.775 -7.974 1.00 21.97 ? 500 TYR A C 1 ATOM 3973 O O . TYR A 1 500 ? -19.169 -19.519 -6.809 1.00 20.46 ? 500 TYR A O 1 ATOM 3974 C CB . TYR A 1 500 ? -16.950 -21.496 -8.406 1.00 19.14 ? 500 TYR A CB 1 ATOM 3975 C CG . TYR A 1 500 ? -17.313 -22.422 -7.229 1.00 19.19 ? 500 TYR A CG 1 ATOM 3976 C CD1 . TYR A 1 500 ? -16.455 -22.591 -6.111 1.00 17.73 ? 500 TYR A CD1 1 ATOM 3977 C CD2 . TYR A 1 500 ? -18.468 -23.178 -7.262 1.00 17.44 ? 500 TYR A CD2 1 ATOM 3978 C CE1 . TYR A 1 500 ? -16.797 -23.414 -5.042 1.00 17.62 ? 500 TYR A CE1 1 ATOM 3979 C CE2 . TYR A 1 500 ? -18.840 -23.973 -6.172 1.00 17.04 ? 500 TYR A CE2 1 ATOM 3980 C CZ . TYR A 1 500 ? -17.977 -24.117 -5.082 1.00 18.48 ? 500 TYR A CZ 1 ATOM 3981 O OH . TYR A 1 500 ? -18.336 -24.982 -4.049 1.00 18.12 ? 500 TYR A OH 1 ATOM 3982 N N . LEU A 1 501 ? -19.547 -19.913 -9.023 1.00 20.76 ? 501 LEU A N 1 ATOM 3983 C CA . LEU A 1 501 ? -21.003 -19.740 -8.958 1.00 22.87 ? 501 LEU A CA 1 ATOM 3984 C C . LEU A 1 501 ? -21.724 -21.097 -9.097 1.00 22.34 ? 501 LEU A C 1 ATOM 3985 O O . LEU A 1 501 ? -21.410 -21.903 -10.011 1.00 20.61 ? 501 LEU A O 1 ATOM 3986 C CB . LEU A 1 501 ? -21.474 -18.780 -10.091 1.00 22.07 ? 501 LEU A CB 1 ATOM 3987 C CG . LEU A 1 501 ? -22.940 -18.393 -10.243 1.00 24.03 ? 501 LEU A CG 1 ATOM 3988 C CD1 . LEU A 1 501 ? -23.302 -17.466 -9.154 1.00 27.53 ? 501 LEU A CD1 1 ATOM 3989 C CD2 . LEU A 1 501 ? -23.250 -17.676 -11.557 1.00 27.61 ? 501 LEU A CD2 1 ATOM 3990 N N . THR A 1 502 ? -22.652 -21.370 -8.176 1.00 21.84 ? 502 THR A N 1 ATOM 3991 C CA . THR A 1 502 ? -23.441 -22.566 -8.253 1.00 22.78 ? 502 THR A CA 1 ATOM 3992 C C . THR A 1 502 ? -24.707 -22.310 -9.118 1.00 23.70 ? 502 THR A C 1 ATOM 3993 O O . THR A 1 502 ? -25.304 -21.229 -9.033 1.00 24.60 ? 502 THR A O 1 ATOM 3994 C CB . THR A 1 502 ? -23.803 -23.123 -6.889 1.00 22.93 ? 502 THR A CB 1 ATOM 3995 O OG1 . THR A 1 502 ? -24.767 -22.266 -6.265 1.00 25.18 ? 502 THR A OG1 1 ATOM 3996 C CG2 . THR A 1 502 ? -22.514 -23.285 -6.011 1.00 21.00 ? 502 THR A CG2 1 ATOM 3997 N N . LEU A 1 503 ? -25.066 -23.275 -9.976 1.00 23.38 ? 503 LEU A N 1 ATOM 3998 C CA . LEU A 1 503 ? -26.234 -23.129 -10.872 1.00 23.54 ? 503 LEU A CA 1 ATOM 3999 C C . LEU A 1 503 ? -27.233 -24.177 -10.422 1.00 25.27 ? 503 LEU A C 1 ATOM 4000 O O . LEU A 1 503 ? -26.949 -25.370 -10.458 1.00 24.03 ? 503 LEU A O 1 ATOM 4001 C CB . LEU A 1 503 ? -25.852 -23.358 -12.330 1.00 21.99 ? 503 LEU A CB 1 ATOM 4002 C CG . LEU A 1 503 ? -24.774 -22.417 -12.887 1.00 21.19 ? 503 LEU A CG 1 ATOM 4003 C CD1 . LEU A 1 503 ? -24.378 -22.791 -14.323 1.00 16.97 ? 503 LEU A CD1 1 ATOM 4004 C CD2 . LEU A 1 503 ? -25.202 -21.010 -12.829 1.00 19.39 ? 503 LEU A CD2 1 ATOM 4005 N N . ASN A 1 504 ? -28.374 -23.716 -9.917 1.00 28.03 ? 504 ASN A N 1 ATOM 4006 C CA . ASN A 1 504 ? -29.425 -24.610 -9.430 1.00 31.51 ? 504 ASN A CA 1 ATOM 4007 C C . ASN A 1 504 ? -30.762 -23.850 -9.499 1.00 33.48 ? 504 ASN A C 1 ATOM 4008 O O . ASN A 1 504 ? -30.778 -22.644 -9.781 1.00 33.94 ? 504 ASN A O 1 ATOM 4009 C CB . ASN A 1 504 ? -29.097 -25.089 -8.032 1.00 30.38 ? 504 ASN A CB 1 ATOM 4010 C CG . ASN A 1 504 ? -29.032 -23.943 -7.071 1.00 33.74 ? 504 ASN A CG 1 ATOM 4011 O OD1 . ASN A 1 504 ? -30.030 -23.275 -6.866 1.00 34.32 ? 504 ASN A OD1 1 ATOM 4012 N ND2 . ASN A 1 504 ? -27.837 -23.658 -6.517 1.00 36.12 ? 504 ASN A ND2 1 ATOM 4013 N N . THR A 1 505 ? -31.885 -24.536 -9.299 1.00 36.26 ? 505 THR A N 1 ATOM 4014 C CA . THR A 1 505 ? -33.168 -23.852 -9.475 1.00 39.38 ? 505 THR A CA 1 ATOM 4015 C C . THR A 1 505 ? -33.530 -22.955 -8.304 1.00 42.61 ? 505 THR A C 1 ATOM 4016 O O . THR A 1 505 ? -34.232 -21.943 -8.489 1.00 43.55 ? 505 THR A O 1 ATOM 4017 C CB . THR A 1 505 ? -34.310 -24.824 -9.703 1.00 39.21 ? 505 THR A CB 1 ATOM 4018 O OG1 . THR A 1 505 ? -34.311 -25.767 -8.628 1.00 38.80 ? 505 THR A OG1 1 ATOM 4019 C CG2 . THR A 1 505 ? -34.129 -25.547 -11.053 1.00 36.78 ? 505 THR A CG2 1 ATOM 4020 N N . GLU A 1 506 ? -33.094 -23.299 -7.097 1.00 45.53 ? 506 GLU A N 1 ATOM 4021 C CA . GLU A 1 506 ? -33.485 -22.439 -5.970 1.00 49.05 ? 506 GLU A CA 1 ATOM 4022 C C . GLU A 1 506 ? -32.807 -21.074 -5.991 1.00 49.58 ? 506 GLU A C 1 ATOM 4023 O O . GLU A 1 506 ? -33.407 -20.093 -6.483 1.00 51.46 ? 506 GLU A O 1 ATOM 4024 C CB . GLU A 1 506 ? -33.286 -23.107 -4.630 1.00 49.80 ? 506 GLU A CB 1 ATOM 4025 C CG . GLU A 1 506 ? -33.722 -24.517 -4.626 1.00 54.64 ? 506 GLU A CG 1 ATOM 4026 C CD . GLU A 1 506 ? -32.525 -25.429 -4.580 1.00 62.46 ? 506 GLU A CD 1 ATOM 4027 O OE1 . GLU A 1 506 ? -31.508 -25.079 -5.249 1.00 65.49 ? 506 GLU A OE1 1 ATOM 4028 O OE2 . GLU A 1 506 ? -32.603 -26.470 -3.862 1.00 64.60 ? 506 GLU A OE2 1 ATOM 4029 N N . SER A 1 507 ? -31.589 -20.970 -5.449 1.00 49.38 ? 507 SER A N 1 ATOM 4030 C CA . SER A 1 507 ? -30.809 -19.753 -5.716 1.00 48.53 ? 507 SER A CA 1 ATOM 4031 C C . SER A 1 507 ? -29.323 -20.016 -5.713 1.00 46.50 ? 507 SER A C 1 ATOM 4032 O O . SER A 1 507 ? -28.815 -20.857 -4.967 1.00 46.14 ? 507 SER A O 1 ATOM 4033 C CB . SER A 1 507 ? -31.192 -18.549 -4.817 1.00 49.77 ? 507 SER A CB 1 ATOM 4034 O OG . SER A 1 507 ? -30.140 -18.150 -3.929 1.00 52.54 ? 507 SER A OG 1 ATOM 4035 N N . THR A 1 508 ? -28.658 -19.290 -6.593 1.00 43.85 ? 508 THR A N 1 ATOM 4036 C CA . THR A 1 508 ? -27.303 -19.542 -6.884 1.00 42.29 ? 508 THR A CA 1 ATOM 4037 C C . THR A 1 508 ? -26.412 -18.848 -5.861 1.00 40.43 ? 508 THR A C 1 ATOM 4038 O O . THR A 1 508 ? -26.696 -17.711 -5.466 1.00 40.76 ? 508 THR A O 1 ATOM 4039 C CB . THR A 1 508 ? -26.999 -19.073 -8.291 1.00 43.10 ? 508 THR A CB 1 ATOM 4040 O OG1 . THR A 1 508 ? -27.042 -17.639 -8.329 1.00 41.98 ? 508 THR A OG1 1 ATOM 4041 C CG2 . THR A 1 508 ? -28.021 -19.740 -9.315 1.00 43.29 ? 508 THR A CG2 1 ATOM 4042 N N . ARG A 1 509 ? -25.349 -19.538 -5.430 1.00 36.97 ? 509 ARG A N 1 ATOM 4043 C CA . ARG A 1 509 ? -24.444 -18.976 -4.474 1.00 33.97 ? 509 ARG A CA 1 ATOM 4044 C C . ARG A 1 509 ? -23.067 -18.733 -5.040 1.00 32.19 ? 509 ARG A C 1 ATOM 4045 O O . ARG A 1 509 ? -22.619 -19.435 -5.965 1.00 29.70 ? 509 ARG A O 1 ATOM 4046 C CB . ARG A 1 509 ? -24.247 -19.921 -3.327 1.00 35.02 ? 509 ARG A CB 1 ATOM 4047 C CG . ARG A 1 509 ? -25.374 -20.842 -3.059 1.00 39.70 ? 509 ARG A CG 1 ATOM 4048 C CD . ARG A 1 509 ? -26.376 -20.156 -2.311 1.00 44.47 ? 509 ARG A CD 1 ATOM 4049 N NE . ARG A 1 509 ? -25.742 -19.048 -1.647 1.00 49.36 ? 509 ARG A NE 1 ATOM 4050 C CZ . ARG A 1 509 ? -26.229 -18.517 -0.534 1.00 51.75 ? 509 ARG A CZ 1 ATOM 4051 N NH1 . ARG A 1 509 ? -27.367 -19.020 -0.028 1.00 49.11 ? 509 ARG A NH1 1 ATOM 4052 N NH2 . ARG A 1 509 ? -25.580 -17.512 0.055 1.00 50.55 ? 509 ARG A NH2 1 ATOM 4053 N N . ILE A 1 510 ? -22.372 -17.775 -4.433 1.00 29.32 ? 510 ILE A N 1 ATOM 4054 C CA . ILE A 1 510 ? -20.965 -17.671 -4.624 1.00 28.78 ? 510 ILE A CA 1 ATOM 4055 C C . ILE A 1 510 ? -20.295 -18.538 -3.524 1.00 28.50 ? 510 ILE A C 1 ATOM 4056 O O . ILE A 1 510 ? -20.559 -18.317 -2.337 1.00 27.06 ? 510 ILE A O 1 ATOM 4057 C CB . ILE A 1 510 ? -20.484 -16.250 -4.468 1.00 28.22 ? 510 ILE A CB 1 ATOM 4058 C CG1 . ILE A 1 510 ? -21.108 -15.285 -5.488 1.00 30.00 ? 510 ILE A CG1 1 ATOM 4059 C CG2 . ILE A 1 510 ? -19.023 -16.227 -4.578 1.00 27.83 ? 510 ILE A CG2 1 ATOM 4060 C CD1 . ILE A 1 510 ? -21.542 -15.961 -6.775 1.00 36.23 ? 510 ILE A CD1 1 ATOM 4061 N N . MET A 1 511 ? -19.419 -19.478 -3.911 1.00 27.10 ? 511 MET A N 1 ATOM 4062 C CA . MET A 1 511 ? -18.627 -20.270 -2.945 1.00 27.43 ? 511 MET A CA 1 ATOM 4063 C C . MET A 1 511 ? -17.201 -20.202 -3.330 1.00 25.66 ? 511 MET A C 1 ATOM 4064 O O . MET A 1 511 ? -16.881 -19.599 -4.342 1.00 24.36 ? 511 MET A O 1 ATOM 4065 C CB . MET A 1 511 ? -18.981 -21.721 -3.042 1.00 28.47 ? 511 MET A CB 1 ATOM 4066 C CG . MET A 1 511 ? -20.435 -21.903 -3.295 1.00 33.97 ? 511 MET A CG 1 ATOM 4067 S SD . MET A 1 511 ? -21.199 -22.038 -1.701 1.00 42.23 ? 511 MET A SD 1 ATOM 4068 C CE . MET A 1 511 ? -21.149 -23.840 -1.635 1.00 36.37 ? 511 MET A CE 1 ATOM 4069 N N . THR A 1 512 ? -16.358 -20.906 -2.578 1.00 23.56 ? 512 THR A N 1 ATOM 4070 C CA . THR A 1 512 ? -14.899 -20.835 -2.769 1.00 22.86 ? 512 THR A CA 1 ATOM 4071 C C . THR A 1 512 ? -14.259 -22.210 -2.657 1.00 21.64 ? 512 THR A C 1 ATOM 4072 O O . THR A 1 512 ? -14.722 -23.078 -1.891 1.00 20.04 ? 512 THR A O 1 ATOM 4073 C CB . THR A 1 512 ? -14.198 -19.897 -1.692 1.00 24.20 ? 512 THR A CB 1 ATOM 4074 O OG1 . THR A 1 512 ? -14.670 -20.276 -0.374 1.00 25.75 ? 512 THR A OG1 1 ATOM 4075 C CG2 . THR A 1 512 ? -14.551 -18.423 -1.927 1.00 24.12 ? 512 THR A CG2 1 ATOM 4076 N N . LYS A 1 513 ? -13.198 -22.410 -3.433 1.00 19.75 ? 513 LYS A N 1 ATOM 4077 C CA . LYS A 1 513 ? -12.380 -23.588 -3.277 1.00 19.17 ? 513 LYS A CA 1 ATOM 4078 C C . LYS A 1 513 ? -13.129 -24.889 -3.380 1.00 19.94 ? 513 LYS A C 1 ATOM 4079 O O . LYS A 1 513 ? -13.050 -25.794 -2.505 1.00 19.42 ? 513 LYS A O 1 ATOM 4080 C CB . LYS A 1 513 ? -11.542 -23.478 -1.993 1.00 21.13 ? 513 LYS A CB 1 ATOM 4081 C CG . LYS A 1 513 ? -10.542 -22.258 -2.037 1.00 21.80 ? 513 LYS A CG 1 ATOM 4082 C CD . LYS A 1 513 ? -9.825 -22.097 -0.739 1.00 30.24 ? 513 LYS A CD 1 ATOM 4083 C CE . LYS A 1 513 ? -9.331 -20.685 -0.612 1.00 37.16 ? 513 LYS A CE 1 ATOM 4084 N NZ . LYS A 1 513 ? -8.413 -20.646 0.544 1.00 44.50 ? 513 LYS A NZ 1 ATOM 4085 N N . LEU A 1 514 ? -13.824 -25.054 -4.501 1.00 19.91 ? 514 LEU A N 1 ATOM 4086 C CA . LEU A 1 514 ? -14.515 -26.317 -4.785 1.00 19.91 ? 514 LEU A CA 1 ATOM 4087 C C . LEU A 1 514 ? -13.588 -27.535 -4.633 1.00 20.68 ? 514 LEU A C 1 ATOM 4088 O O . LEU A 1 514 ? -12.491 -27.541 -5.160 1.00 21.05 ? 514 LEU A O 1 ATOM 4089 C CB . LEU A 1 514 ? -15.037 -26.279 -6.214 1.00 18.79 ? 514 LEU A CB 1 ATOM 4090 C CG . LEU A 1 514 ? -15.762 -27.516 -6.750 1.00 19.20 ? 514 LEU A CG 1 ATOM 4091 C CD1 . LEU A 1 514 ? -17.061 -27.711 -6.041 1.00 17.13 ? 514 LEU A CD1 1 ATOM 4092 C CD2 . LEU A 1 514 ? -16.072 -27.266 -8.255 1.00 17.70 ? 514 LEU A CD2 1 ATOM 4093 N N . ARG A 1 515 ? -14.034 -28.574 -3.941 1.00 21.48 ? 515 ARG A N 1 ATOM 4094 C CA . ARG A 1 515 ? -13.239 -29.819 -3.821 1.00 22.97 ? 515 ARG A CA 1 ATOM 4095 C C . ARG A 1 515 ? -11.809 -29.590 -3.347 1.00 23.14 ? 515 ARG A C 1 ATOM 4096 O O . ARG A 1 515 ? -10.880 -30.246 -3.806 1.00 22.38 ? 515 ARG A O 1 ATOM 4097 C CB . ARG A 1 515 ? -13.209 -30.595 -5.147 1.00 23.57 ? 515 ARG A CB 1 ATOM 4098 C CG . ARG A 1 515 ? -14.597 -31.032 -5.610 1.00 25.37 ? 515 ARG A CG 1 ATOM 4099 C CD . ARG A 1 515 ? -15.101 -32.304 -4.959 1.00 28.15 ? 515 ARG A CD 1 ATOM 4100 N NE . ARG A 1 515 ? -16.144 -32.908 -5.799 1.00 30.92 ? 515 ARG A NE 1 ATOM 4101 C CZ . ARG A 1 515 ? -17.380 -32.415 -5.923 1.00 35.04 ? 515 ARG A CZ 1 ATOM 4102 N NH1 . ARG A 1 515 ? -18.298 -32.976 -6.768 1.00 31.93 ? 515 ARG A NH1 1 ATOM 4103 N NH2 . ARG A 1 515 ? -17.708 -31.357 -5.189 1.00 33.51 ? 515 ARG A NH2 1 ATOM 4104 N N . ALA A 1 516 ? -11.612 -28.651 -2.436 1.00 24.54 ? 516 ALA A N 1 ATOM 4105 C CA . ALA A 1 516 ? -10.233 -28.261 -2.107 1.00 25.23 ? 516 ALA A CA 1 ATOM 4106 C C . ALA A 1 516 ? -9.444 -29.502 -1.708 1.00 25.28 ? 516 ALA A C 1 ATOM 4107 O O . ALA A 1 516 ? -8.401 -29.762 -2.266 1.00 24.68 ? 516 ALA A O 1 ATOM 4108 C CB . ALA A 1 516 ? -10.196 -27.184 -0.960 1.00 25.78 ? 516 ALA A CB 1 ATOM 4109 N N . GLN A 1 517 ? -9.949 -30.276 -0.768 1.00 25.91 ? 517 GLN A N 1 ATOM 4110 C CA . GLN A 1 517 ? -9.130 -31.394 -0.200 1.00 28.88 ? 517 GLN A CA 1 ATOM 4111 C C . GLN A 1 517 ? -8.904 -32.492 -1.246 1.00 28.50 ? 517 GLN A C 1 ATOM 4112 O O . GLN A 1 517 ? -7.833 -33.084 -1.339 1.00 28.13 ? 517 GLN A O 1 ATOM 4113 C CB . GLN A 1 517 ? -9.859 -32.032 0.988 1.00 30.15 ? 517 GLN A CB 1 ATOM 4114 C CG . GLN A 1 517 ? -9.679 -31.338 2.347 1.00 34.40 ? 517 GLN A CG 1 ATOM 4115 C CD . GLN A 1 517 ? -10.233 -32.218 3.471 0.50 36.59 ? 517 GLN A CD 1 ATOM 4116 O OE1 . GLN A 1 517 ? -9.806 -32.128 4.622 0.50 36.87 ? 517 GLN A OE1 1 ATOM 4117 N NE2 . GLN A 1 517 ? -11.176 -33.092 3.121 0.50 35.97 ? 517 GLN A NE2 1 ATOM 4118 N N . GLN A 1 518 ? -9.945 -32.750 -2.037 1.00 27.52 ? 518 GLN A N 1 ATOM 4119 C CA . GLN A 1 518 ? -9.873 -33.787 -3.093 1.00 25.96 ? 518 GLN A CA 1 ATOM 4120 C C . GLN A 1 518 ? -8.890 -33.471 -4.147 1.00 26.38 ? 518 GLN A C 1 ATOM 4121 O O . GLN A 1 518 ? -8.081 -34.308 -4.547 1.00 28.58 ? 518 GLN A O 1 ATOM 4122 C CB . GLN A 1 518 ? -11.251 -33.941 -3.708 1.00 24.64 ? 518 GLN A CB 1 ATOM 4123 C CG . GLN A 1 518 ? -12.200 -34.520 -2.735 1.00 25.65 ? 518 GLN A CG 1 ATOM 4124 C CD . GLN A 1 518 ? -13.065 -33.479 -1.988 1.00 30.06 ? 518 GLN A CD 1 ATOM 4125 O OE1 . GLN A 1 518 ? -14.189 -33.765 -1.624 1.00 35.16 ? 518 GLN A OE1 1 ATOM 4126 N NE2 . GLN A 1 518 ? -12.538 -32.312 -1.746 1.00 31.13 ? 518 GLN A NE2 1 ATOM 4127 N N . CYS A 1 519 ? -8.916 -32.239 -4.647 1.00 26.46 ? 519 CYS A N 1 ATOM 4128 C CA . CYS A 1 519 ? -8.086 -31.914 -5.770 1.00 26.19 ? 519 CYS A CA 1 ATOM 4129 C C . CYS A 1 519 ? -6.642 -31.769 -5.340 1.00 26.96 ? 519 CYS A C 1 ATOM 4130 O O . CYS A 1 519 ? -5.723 -32.045 -6.143 1.00 26.24 ? 519 CYS A O 1 ATOM 4131 C CB . CYS A 1 519 ? -8.611 -30.651 -6.430 1.00 26.48 ? 519 CYS A CB 1 ATOM 4132 S SG . CYS A 1 519 ? -10.201 -30.940 -7.255 1.00 30.27 ? 519 CYS A SG 1 ATOM 4133 N N . ARG A 1 520 ? -6.400 -31.351 -4.082 1.00 26.21 ? 520 ARG A N 1 ATOM 4134 C CA . ARG A 1 520 ? -5.005 -31.426 -3.575 1.00 27.80 ? 520 ARG A CA 1 ATOM 4135 C C . ARG A 1 520 ? -4.473 -32.841 -3.723 1.00 26.42 ? 520 ARG A C 1 ATOM 4136 O O . ARG A 1 520 ? -3.376 -33.026 -4.111 1.00 26.32 ? 520 ARG A O 1 ATOM 4137 C CB . ARG A 1 520 ? -4.842 -30.983 -2.109 1.00 26.97 ? 520 ARG A CB 1 ATOM 4138 C CG . ARG A 1 520 ? -5.078 -29.489 -1.871 1.00 34.13 ? 520 ARG A CG 1 ATOM 4139 C CD . ARG A 1 520 ? -4.871 -29.056 -0.321 1.00 38.34 ? 520 ARG A CD 1 ATOM 4140 N NE . ARG A 1 520 ? -5.755 -27.934 0.040 1.00 43.24 ? 520 ARG A NE 1 ATOM 4141 C CZ . ARG A 1 520 ? -6.722 -28.007 0.958 1.00 47.21 ? 520 ARG A CZ 1 ATOM 4142 N NH1 . ARG A 1 520 ? -7.486 -26.941 1.213 1.00 52.60 ? 520 ARG A NH1 1 ATOM 4143 N NH2 . ARG A 1 520 ? -6.919 -29.131 1.646 1.00 45.20 ? 520 ARG A NH2 1 ATOM 4144 N N . PHE A 1 521 ? -5.270 -33.838 -3.382 1.00 27.34 ? 521 PHE A N 1 ATOM 4145 C CA . PHE A 1 521 ? -4.907 -35.240 -3.682 1.00 27.19 ? 521 PHE A CA 1 ATOM 4146 C C . PHE A 1 521 ? -4.626 -35.570 -5.188 1.00 27.48 ? 521 PHE A C 1 ATOM 4147 O O . PHE A 1 521 ? -3.592 -36.123 -5.547 1.00 27.49 ? 521 PHE A O 1 ATOM 4148 C CB . PHE A 1 521 ? -5.962 -36.188 -3.090 1.00 25.49 ? 521 PHE A CB 1 ATOM 4149 C CG . PHE A 1 521 ? -5.705 -37.641 -3.439 1.00 28.23 ? 521 PHE A CG 1 ATOM 4150 C CD1 . PHE A 1 521 ? -4.692 -38.373 -2.759 1.00 26.10 ? 521 PHE A CD1 1 ATOM 4151 C CD2 . PHE A 1 521 ? -6.455 -38.272 -4.443 1.00 27.30 ? 521 PHE A CD2 1 ATOM 4152 C CE1 . PHE A 1 521 ? -4.426 -39.673 -3.095 1.00 26.55 ? 521 PHE A CE1 1 ATOM 4153 C CE2 . PHE A 1 521 ? -6.219 -39.607 -4.788 1.00 28.00 ? 521 PHE A CE2 1 ATOM 4154 C CZ . PHE A 1 521 ? -5.196 -40.322 -4.104 1.00 26.01 ? 521 PHE A CZ 1 ATOM 4155 N N . TRP A 1 522 ? -5.547 -35.243 -6.080 1.00 28.88 ? 522 TRP A N 1 ATOM 4156 C CA . TRP A 1 522 ? -5.404 -35.655 -7.482 1.00 28.81 ? 522 TRP A CA 1 ATOM 4157 C C . TRP A 1 522 ? -4.328 -34.871 -8.129 1.00 31.39 ? 522 TRP A C 1 ATOM 4158 O O . TRP A 1 522 ? -3.568 -35.360 -8.956 1.00 31.16 ? 522 TRP A O 1 ATOM 4159 C CB . TRP A 1 522 ? -6.742 -35.459 -8.235 1.00 27.38 ? 522 TRP A CB 1 ATOM 4160 C CG . TRP A 1 522 ? -7.744 -36.480 -7.781 1.00 23.22 ? 522 TRP A CG 1 ATOM 4161 C CD1 . TRP A 1 522 ? -8.878 -36.255 -7.047 1.00 19.67 ? 522 TRP A CD1 1 ATOM 4162 C CD2 . TRP A 1 522 ? -7.654 -37.899 -7.973 1.00 22.05 ? 522 TRP A CD2 1 ATOM 4163 N NE1 . TRP A 1 522 ? -9.491 -37.446 -6.742 1.00 19.63 ? 522 TRP A NE1 1 ATOM 4164 C CE2 . TRP A 1 522 ? -8.758 -38.477 -7.310 1.00 22.82 ? 522 TRP A CE2 1 ATOM 4165 C CE3 . TRP A 1 522 ? -6.711 -38.747 -8.604 1.00 22.94 ? 522 TRP A CE3 1 ATOM 4166 C CZ2 . TRP A 1 522 ? -8.979 -39.869 -7.293 1.00 20.22 ? 522 TRP A CZ2 1 ATOM 4167 C CZ3 . TRP A 1 522 ? -6.941 -40.140 -8.593 1.00 20.74 ? 522 TRP A CZ3 1 ATOM 4168 C CH2 . TRP A 1 522 ? -8.071 -40.680 -7.939 1.00 21.04 ? 522 TRP A CH2 1 ATOM 4169 N N . THR A 1 523 ? -4.270 -33.608 -7.731 1.00 34.28 ? 523 THR A N 1 ATOM 4170 C CA . THR A 1 523 ? -3.460 -32.653 -8.427 1.00 36.70 ? 523 THR A CA 1 ATOM 4171 C C . THR A 1 523 ? -2.032 -32.681 -7.925 1.00 38.49 ? 523 THR A C 1 ATOM 4172 O O . THR A 1 523 ? -1.107 -32.664 -8.717 1.00 38.08 ? 523 THR A O 1 ATOM 4173 C CB . THR A 1 523 ? -4.124 -31.263 -8.381 1.00 36.66 ? 523 THR A CB 1 ATOM 4174 O OG1 . THR A 1 523 ? -5.468 -31.411 -8.871 1.00 37.55 ? 523 THR A OG1 1 ATOM 4175 C CG2 . THR A 1 523 ? -3.397 -30.267 -9.292 1.00 36.53 ? 523 THR A CG2 1 ATOM 4176 N N . SER A 1 524 ? -1.826 -32.761 -6.617 1.00 40.72 ? 524 SER A N 1 ATOM 4177 C CA . SER A 1 524 ? -0.445 -32.712 -6.138 1.00 42.72 ? 524 SER A CA 1 ATOM 4178 C C . SER A 1 524 ? 0.133 -34.077 -5.970 1.00 43.37 ? 524 SER A C 1 ATOM 4179 O O . SER A 1 524 ? 1.153 -34.375 -6.574 1.00 45.74 ? 524 SER A O 1 ATOM 4180 C CB . SER A 1 524 ? -0.318 -31.958 -4.809 1.00 43.25 ? 524 SER A CB 1 ATOM 4181 O OG . SER A 1 524 ? -0.646 -30.593 -5.022 1.00 46.24 ? 524 SER A OG 1 ATOM 4182 N N . PHE A 1 525 ? -0.512 -34.914 -5.154 1.00 42.80 ? 525 PHE A N 1 ATOM 4183 C CA . PHE A 1 525 ? 0.008 -36.235 -4.896 1.00 42.33 ? 525 PHE A CA 1 ATOM 4184 C C . PHE A 1 525 ? -0.123 -37.321 -6.007 1.00 41.66 ? 525 PHE A C 1 ATOM 4185 O O . PHE A 1 525 ? 0.892 -37.852 -6.495 1.00 41.61 ? 525 PHE A O 1 ATOM 4186 C CB . PHE A 1 525 ? -0.582 -36.821 -3.630 1.00 42.21 ? 525 PHE A CB 1 ATOM 4187 C CG . PHE A 1 525 ? -0.258 -38.258 -3.496 1.00 46.50 ? 525 PHE A CG 1 ATOM 4188 C CD1 . PHE A 1 525 ? 1.064 -38.679 -3.648 1.00 51.34 ? 525 PHE A CD1 1 ATOM 4189 C CD2 . PHE A 1 525 ? -1.227 -39.192 -3.291 1.00 49.51 ? 525 PHE A CD2 1 ATOM 4190 C CE1 . PHE A 1 525 ? 1.411 -40.007 -3.554 1.00 53.04 ? 525 PHE A CE1 1 ATOM 4191 C CE2 . PHE A 1 525 ? -0.897 -40.534 -3.213 1.00 51.71 ? 525 PHE A CE2 1 ATOM 4192 C CZ . PHE A 1 525 ? 0.425 -40.940 -3.348 1.00 52.67 ? 525 PHE A CZ 1 ATOM 4193 N N . PHE A 1 526 ? -1.361 -37.684 -6.376 1.00 40.49 ? 526 PHE A N 1 ATOM 4194 C CA . PHE A 1 526 ? -1.587 -38.817 -7.304 1.00 38.48 ? 526 PHE A CA 1 ATOM 4195 C C . PHE A 1 526 ? -0.659 -38.881 -8.547 1.00 38.28 ? 526 PHE A C 1 ATOM 4196 O O . PHE A 1 526 ? -0.225 -39.961 -8.947 1.00 38.53 ? 526 PHE A O 1 ATOM 4197 C CB . PHE A 1 526 ? -3.064 -38.936 -7.716 1.00 37.09 ? 526 PHE A CB 1 ATOM 4198 C CG . PHE A 1 526 ? -3.410 -40.248 -8.417 1.00 34.54 ? 526 PHE A CG 1 ATOM 4199 C CD1 . PHE A 1 526 ? -3.562 -41.415 -7.701 1.00 33.49 ? 526 PHE A CD1 1 ATOM 4200 C CD2 . PHE A 1 526 ? -3.567 -40.302 -9.800 1.00 35.36 ? 526 PHE A CD2 1 ATOM 4201 C CE1 . PHE A 1 526 ? -3.879 -42.615 -8.338 1.00 31.11 ? 526 PHE A CE1 1 ATOM 4202 C CE2 . PHE A 1 526 ? -3.910 -41.505 -10.451 1.00 32.83 ? 526 PHE A CE2 1 ATOM 4203 C CZ . PHE A 1 526 ? -4.080 -42.652 -9.704 1.00 33.47 ? 526 PHE A CZ 1 ATOM 4204 N N . PRO A 1 527 ? -0.346 -37.731 -9.160 1.00 38.57 ? 527 PRO A N 1 ATOM 4205 C CA . PRO A 1 527 ? 0.465 -37.861 -10.398 1.00 38.97 ? 527 PRO A CA 1 ATOM 4206 C C . PRO A 1 527 ? 1.891 -38.401 -10.167 1.00 39.97 ? 527 PRO A C 1 ATOM 4207 O O . PRO A 1 527 ? 2.599 -38.684 -11.147 1.00 40.12 ? 527 PRO A O 1 ATOM 4208 C CB . PRO A 1 527 ? 0.521 -36.428 -10.966 1.00 38.22 ? 527 PRO A CB 1 ATOM 4209 C CG . PRO A 1 527 ? -0.428 -35.603 -10.080 1.00 39.62 ? 527 PRO A CG 1 ATOM 4210 C CD . PRO A 1 527 ? -0.574 -36.332 -8.766 1.00 37.23 ? 527 PRO A CD 1 ATOM 4211 N N . LYS A 1 528 ? 2.315 -38.512 -8.900 1.00 40.38 ? 528 LYS A N 1 ATOM 4212 C C . LYS A 1 528 ? 3.205 -40.330 -8.652 1.00 59.56 ? 528 LYS A C 1 ATOM 4213 O O . LYS A 1 528 ? 4.322 -40.811 -8.846 1.00 59.40 ? 528 LYS A O 1 ATOM 4214 C CB . LYS A 1 528 ? 3.701 -38.861 -7.446 1.00 40.19 ? 528 LYS A CB 1 ATOM 4215 C CG . LYS A 1 528 ? 4.416 -37.545 -7.362 1.00 45.13 ? 528 LYS A CG 1 ATOM 4216 C CD . LYS A 1 528 ? 4.300 -36.971 -5.972 1.00 45.91 ? 528 LYS A CD 1 ATOM 4217 C CE . LYS A 1 528 ? 4.435 -35.476 -6.014 1.00 48.74 ? 528 LYS A CE 1 ATOM 4218 N NZ . LYS A 1 528 ? 4.161 -34.843 -4.699 1.00 49.72 ? 528 LYS A NZ 1 ATOM 4219 N N . VAL A 1 529 ? 2.152 -41.065 -8.316 1.00 59.39 ? 529 VAL A N 1 ATOM 4220 C CA . VAL A 1 529 ? 2.284 -42.475 -7.985 1.00 59.84 ? 529 VAL A CA 1 ATOM 4221 C C . VAL A 1 529 ? 2.526 -43.390 -9.218 1.00 60.29 ? 529 VAL A C 1 ATOM 4222 O O . VAL A 1 529 ? 2.813 -42.987 -10.370 1.00 60.30 ? 529 VAL A O 1 ATOM 4223 C CB . VAL A 1 529 ? 1.046 -42.993 -7.186 1.00 59.72 ? 529 VAL A CB 1 ATOM 4224 C CG1 . VAL A 1 529 ? 0.665 -42.033 -6.085 1.00 58.51 ? 529 VAL A CG1 1 ATOM 4225 C CG2 . VAL A 1 529 ? -0.130 -43.216 -8.117 1.00 59.94 ? 529 VAL A CG2 1 ATOM 4226 O OXT . VAL A 1 529 ? 2.422 -44.615 -9.070 1.00 60.81 ? 529 VAL A OXT 1 HETATM 4227 C C2 . TC3 B 2 . ? -13.675 -39.287 -22.098 1.00 30.19 ? 601 TC3 A C2 1 HETATM 4228 C C1 . TC3 B 2 . ? -14.573 -38.313 -21.334 1.00 28.61 ? 601 TC3 A C1 1 HETATM 4229 O O3 . TC3 B 2 . ? -14.837 -37.324 -22.259 1.00 29.39 ? 601 TC3 A O3 1 HETATM 4230 P P . TC3 B 2 . ? -16.264 -36.823 -22.716 1.00 27.11 ? 601 TC3 A P 1 HETATM 4231 O O2 . TC3 B 2 . ? -16.208 -36.660 -24.158 1.00 26.26 ? 601 TC3 A O2 1 HETATM 4232 N N . TC3 B 2 . ? -17.373 -37.790 -22.018 1.00 27.17 ? 601 TC3 A N 1 HETATM 4233 C C3 . TC3 B 2 . ? -17.845 -38.964 -22.807 1.00 29.97 ? 601 TC3 A C3 1 HETATM 4234 NA NA . NA C 3 . ? 0.000 -40.342 0.000 0.50 64.69 ? 602 NA A NA 1 HETATM 4235 S S . SO4 D 4 . ? -21.163 -31.704 -3.464 0.75 49.85 ? 603 SO4 A S 1 HETATM 4236 O O1 . SO4 D 4 . ? -20.815 -33.108 -3.607 0.75 48.68 ? 603 SO4 A O1 1 HETATM 4237 O O2 . SO4 D 4 . ? -21.756 -31.151 -4.669 0.75 47.33 ? 603 SO4 A O2 1 HETATM 4238 O O3 . SO4 D 4 . ? -22.146 -31.550 -2.418 0.75 51.08 ? 603 SO4 A O3 1 HETATM 4239 O O4 . SO4 D 4 . ? -19.922 -30.999 -3.097 0.75 49.76 ? 603 SO4 A O4 1 HETATM 4240 CL CL . CL E 5 . ? -33.827 -35.063 -24.708 1.00 75.31 ? 604 CL A CL 1 HETATM 4241 CL CL . CL F 5 . ? -22.714 -42.391 9.715 1.00 73.15 ? 605 CL A CL 1 HETATM 4242 CL CL . CL G 5 . ? -16.483 -29.467 -2.178 1.00 71.21 ? 606 CL A CL 1 HETATM 4243 S S . SO4 H 4 . ? -9.480 -9.542 -19.217 0.80 38.01 ? 607 SO4 A S 1 HETATM 4244 O O1 . SO4 H 4 . ? -9.595 -8.738 -20.449 0.80 36.01 ? 607 SO4 A O1 1 HETATM 4245 O O2 . SO4 H 4 . ? -9.504 -10.992 -19.537 0.80 33.53 ? 607 SO4 A O2 1 HETATM 4246 O O3 . SO4 H 4 . ? -10.579 -9.210 -18.304 0.80 37.98 ? 607 SO4 A O3 1 HETATM 4247 O O4 . SO4 H 4 . ? -8.242 -9.166 -18.513 0.80 33.30 ? 607 SO4 A O4 1 HETATM 4248 CL CL . CL I 5 . ? -8.770 -54.099 3.123 1.00 63.51 ? 608 CL A CL 1 HETATM 4249 C C1 . NAG J 6 . ? -27.976 -54.278 -8.773 1.00 44.59 ? 609 NAG A C1 1 HETATM 4250 C C2 . NAG J 6 . ? -27.688 -55.347 -7.725 1.00 46.71 ? 609 NAG A C2 1 HETATM 4251 C C3 . NAG J 6 . ? -26.359 -56.015 -7.989 1.00 50.15 ? 609 NAG A C3 1 HETATM 4252 C C4 . NAG J 6 . ? -26.219 -56.467 -9.421 1.00 52.66 ? 609 NAG A C4 1 HETATM 4253 C C5 . NAG J 6 . ? -26.512 -55.276 -10.291 1.00 51.94 ? 609 NAG A C5 1 HETATM 4254 C C6 . NAG J 6 . ? -26.301 -55.496 -11.790 1.00 56.25 ? 609 NAG A C6 1 HETATM 4255 C C7 . NAG J 6 . ? -28.487 -54.330 -5.637 1.00 50.58 ? 609 NAG A C7 1 HETATM 4256 C C8 . NAG J 6 . ? -29.894 -54.737 -5.942 1.00 48.90 ? 609 NAG A C8 1 HETATM 4257 N N2 . NAG J 6 . ? -27.523 -54.822 -6.410 1.00 48.43 ? 609 NAG A N2 1 HETATM 4258 O O3 . NAG J 6 . ? -26.168 -57.099 -7.112 1.00 50.10 ? 609 NAG A O3 1 HETATM 4259 O O4 . NAG J 6 . ? -24.873 -56.770 -9.575 1.00 59.67 ? 609 NAG A O4 1 HETATM 4260 O O5 . NAG J 6 . ? -27.829 -54.890 -10.025 1.00 47.74 ? 609 NAG A O5 1 HETATM 4261 O O6 . NAG J 6 . ? -26.330 -56.837 -12.246 1.00 61.85 ? 609 NAG A O6 1 HETATM 4262 O O7 . NAG J 6 . ? -28.232 -53.551 -4.700 1.00 52.89 ? 609 NAG A O7 1 HETATM 4263 C C1 . NAG K 6 . ? -24.843 -58.181 -9.728 1.00 64.99 ? 610 NAG A C1 1 HETATM 4264 C C2 . NAG K 6 . ? -23.574 -58.681 -10.403 1.00 66.09 ? 610 NAG A C2 1 HETATM 4265 C C3 . NAG K 6 . ? -23.645 -60.191 -10.589 1.00 67.49 ? 610 NAG A C3 1 HETATM 4266 C C4 . NAG K 6 . ? -24.322 -60.887 -9.399 1.00 69.26 ? 610 NAG A C4 1 HETATM 4267 C C5 . NAG K 6 . ? -25.547 -60.108 -8.888 1.00 70.67 ? 610 NAG A C5 1 HETATM 4268 C C6 . NAG K 6 . ? -26.182 -60.820 -7.708 1.00 71.55 ? 610 NAG A C6 1 HETATM 4269 C C7 . NAG K 6 . ? -22.399 -57.593 -12.287 1.00 68.90 ? 610 NAG A C7 1 HETATM 4270 C C8 . NAG K 6 . ? -21.737 -58.505 -13.294 1.00 69.53 ? 610 NAG A C8 1 HETATM 4271 N N2 . NAG K 6 . ? -23.511 -58.062 -11.710 1.00 67.37 ? 610 NAG A N2 1 HETATM 4272 O O3 . NAG K 6 . ? -22.343 -60.697 -10.772 1.00 66.48 ? 610 NAG A O3 1 HETATM 4273 O O4 . NAG K 6 . ? -24.700 -62.213 -9.716 1.00 69.19 ? 610 NAG A O4 1 HETATM 4274 O O5 . NAG K 6 . ? -25.118 -58.822 -8.510 1.00 67.80 ? 610 NAG A O5 1 HETATM 4275 O O6 . NAG K 6 . ? -25.461 -62.029 -7.604 1.00 73.14 ? 610 NAG A O6 1 HETATM 4276 O O7 . NAG K 6 . ? -21.934 -56.475 -12.036 1.00 68.08 ? 610 NAG A O7 1 HETATM 4277 C C1 . FUL L 7 . ? -27.704 -57.237 -12.350 1.00 66.00 ? 611 FUL A C1 1 HETATM 4278 C C2 . FUL L 7 . ? -27.980 -58.497 -13.136 1.00 68.06 ? 611 FUL A C2 1 HETATM 4279 O O2 . FUL L 7 . ? -26.843 -59.324 -13.239 1.00 68.25 ? 611 FUL A O2 1 HETATM 4280 C C3 . FUL L 7 . ? -29.125 -59.058 -12.298 1.00 69.50 ? 611 FUL A C3 1 HETATM 4281 O O3 . FUL L 7 . ? -29.576 -60.256 -12.870 1.00 72.03 ? 611 FUL A O3 1 HETATM 4282 C C4 . FUL L 7 . ? -30.284 -58.041 -12.255 1.00 69.29 ? 611 FUL A C4 1 HETATM 4283 O O4 . FUL L 7 . ? -31.057 -58.191 -13.437 1.00 69.42 ? 611 FUL A O4 1 HETATM 4284 C C5 . FUL L 7 . ? -29.816 -56.567 -12.086 1.00 67.71 ? 611 FUL A C5 1 HETATM 4285 C C6 . FUL L 7 . ? -30.866 -55.473 -12.328 1.00 64.46 ? 611 FUL A C6 1 HETATM 4286 O O5 . FUL L 7 . ? -28.656 -56.338 -12.873 1.00 67.11 ? 611 FUL A O5 1 HETATM 4287 C C1 . NAG M 6 . ? -19.136 -5.550 -36.627 1.00 58.52 ? 612 NAG A C1 1 HETATM 4288 C C2 . NAG M 6 . ? -18.847 -4.579 -37.793 1.00 62.69 ? 612 NAG A C2 1 HETATM 4289 C C3 . NAG M 6 . ? -17.353 -4.287 -37.990 1.00 64.43 ? 612 NAG A C3 1 HETATM 4290 C C4 . NAG M 6 . ? -16.643 -3.948 -36.684 1.00 64.97 ? 612 NAG A C4 1 HETATM 4291 C C5 . NAG M 6 . ? -17.007 -5.072 -35.696 1.00 65.47 ? 612 NAG A C5 1 HETATM 4292 C C6 . NAG M 6 . ? -16.249 -5.035 -34.356 1.00 68.68 ? 612 NAG A C6 1 HETATM 4293 C C7 . NAG M 6 . ? -20.558 -4.591 -39.559 1.00 62.21 ? 612 NAG A C7 1 HETATM 4294 C C8 . NAG M 6 . ? -21.533 -3.866 -38.661 1.00 62.51 ? 612 NAG A C8 1 HETATM 4295 N N2 . NAG M 6 . ? -19.417 -5.053 -39.052 1.00 61.66 ? 612 NAG A N2 1 HETATM 4296 O O3 . NAG M 6 . ? -17.189 -3.223 -38.900 1.00 67.37 ? 612 NAG A O3 1 HETATM 4297 O O4 . NAG M 6 . ? -15.246 -3.831 -36.944 1.00 63.00 ? 612 NAG A O4 1 HETATM 4298 O O5 . NAG M 6 . ? -18.416 -5.100 -35.486 1.00 61.40 ? 612 NAG A O5 1 HETATM 4299 O O6 . NAG M 6 . ? -16.697 -6.078 -33.513 1.00 72.97 ? 612 NAG A O6 1 HETATM 4300 O O7 . NAG M 6 . ? -20.830 -4.752 -40.744 1.00 63.65 ? 612 NAG A O7 1 HETATM 4301 C C1 . FUL N 7 . ? -16.356 -5.777 -32.142 1.00 76.66 ? 613 FUL A C1 1 HETATM 4302 C C2 . FUL N 7 . ? -15.349 -6.799 -31.584 1.00 78.22 ? 613 FUL A C2 1 HETATM 4303 O O2 . FUL N 7 . ? -14.120 -6.168 -31.264 1.00 77.83 ? 613 FUL A O2 1 HETATM 4304 C C3 . FUL N 7 . ? -15.790 -7.672 -30.396 1.00 78.78 ? 613 FUL A C3 1 HETATM 4305 O O3 . FUL N 7 . ? -15.825 -9.005 -30.825 1.00 78.82 ? 613 FUL A O3 1 HETATM 4306 C C4 . FUL N 7 . ? -17.147 -7.396 -29.745 1.00 79.99 ? 613 FUL A C4 1 HETATM 4307 O O4 . FUL N 7 . ? -17.707 -8.644 -29.307 1.00 79.88 ? 613 FUL A O4 1 HETATM 4308 C C5 . FUL N 7 . ? -18.115 -6.560 -30.611 1.00 79.25 ? 613 FUL A C5 1 HETATM 4309 C C6 . FUL N 7 . ? -18.955 -7.382 -31.569 1.00 78.93 ? 613 FUL A C6 1 HETATM 4310 O O5 . FUL N 7 . ? -17.488 -5.508 -31.329 1.00 78.61 ? 613 FUL A O5 1 HETATM 4311 C C1 . NAG O 6 . ? -33.567 -27.930 -53.130 1.00 75.41 ? 614 NAG A C1 1 HETATM 4312 C C2 . NAG O 6 . ? -34.460 -27.938 -54.388 1.00 79.72 ? 614 NAG A C2 1 HETATM 4313 C C3 . NAG O 6 . ? -35.669 -26.995 -54.295 1.00 80.68 ? 614 NAG A C3 1 HETATM 4314 C C4 . NAG O 6 . ? -36.496 -27.308 -53.052 1.00 81.59 ? 614 NAG A C4 1 HETATM 4315 C C5 . NAG O 6 . ? -35.511 -27.224 -51.865 1.00 82.58 ? 614 NAG A C5 1 HETATM 4316 C C6 . NAG O 6 . ? -36.175 -27.278 -50.472 1.00 83.58 ? 614 NAG A C6 1 HETATM 4317 C C7 . NAG O 6 . ? -33.113 -28.630 -56.246 1.00 79.30 ? 614 NAG A C7 1 HETATM 4318 C C8 . NAG O 6 . ? -33.818 -29.091 -57.493 1.00 78.42 ? 614 NAG A C8 1 HETATM 4319 N N2 . NAG O 6 . ? -33.697 -27.640 -55.586 1.00 79.71 ? 614 NAG A N2 1 HETATM 4320 O O3 . NAG O 6 . ? -36.473 -27.103 -55.450 1.00 81.16 ? 614 NAG A O3 1 HETATM 4321 O O4 . NAG O 6 . ? -37.584 -26.396 -52.959 1.00 80.20 ? 614 NAG A O4 1 HETATM 4322 O O5 . NAG O 6 . ? -34.435 -28.172 -52.013 1.00 80.68 ? 614 NAG A O5 1 HETATM 4323 O O6 . NAG O 6 . ? -36.869 -28.497 -50.278 1.00 83.75 ? 614 NAG A O6 1 HETATM 4324 O O7 . NAG O 6 . ? -32.067 -29.148 -55.842 1.00 78.01 ? 614 NAG A O7 1 HETATM 4325 C C1 . NAG P 6 . ? -36.277 -11.988 -15.983 1.00 62.14 ? 615 NAG A C1 1 HETATM 4326 C C2 . NAG P 6 . ? -36.090 -12.966 -17.156 1.00 64.07 ? 615 NAG A C2 1 HETATM 4327 C C3 . NAG P 6 . ? -37.380 -13.152 -17.977 1.00 67.53 ? 615 NAG A C3 1 HETATM 4328 C C4 . NAG P 6 . ? -38.580 -13.388 -17.043 1.00 69.65 ? 615 NAG A C4 1 HETATM 4329 C C5 . NAG P 6 . ? -38.623 -12.242 -16.021 1.00 70.23 ? 615 NAG A C5 1 HETATM 4330 C C6 . NAG P 6 . ? -39.913 -12.182 -15.169 1.00 71.19 ? 615 NAG A C6 1 HETATM 4331 C C7 . NAG P 6 . ? -33.837 -13.374 -17.889 1.00 55.79 ? 615 NAG A C7 1 HETATM 4332 C C8 . NAG P 6 . ? -32.797 -13.158 -18.946 1.00 52.96 ? 615 NAG A C8 1 HETATM 4333 N N2 . NAG P 6 . ? -34.941 -12.611 -17.973 1.00 58.51 ? 615 NAG A N2 1 HETATM 4334 O O3 . NAG P 6 . ? -37.260 -14.203 -18.917 1.00 68.53 ? 615 NAG A O3 1 HETATM 4335 O O4 . NAG P 6 . ? -39.792 -13.412 -17.775 1.00 71.84 ? 615 NAG A O4 1 HETATM 4336 O O5 . NAG P 6 . ? -37.438 -12.363 -15.242 1.00 67.26 ? 615 NAG A O5 1 HETATM 4337 O O6 . NAG P 6 . ? -39.789 -11.383 -13.995 1.00 71.27 ? 615 NAG A O6 1 HETATM 4338 O O7 . NAG P 6 . ? -33.647 -14.232 -17.008 1.00 52.17 ? 615 NAG A O7 1 HETATM 4339 C C1 . NAG Q 6 . ? 8.920 -46.571 -47.579 1.00 83.61 ? 616 NAG A C1 1 HETATM 4340 C C2 . NAG Q 6 . ? 10.129 -45.971 -48.286 1.00 86.40 ? 616 NAG A C2 1 HETATM 4341 C C3 . NAG Q 6 . ? 9.618 -44.711 -48.983 1.00 87.56 ? 616 NAG A C3 1 HETATM 4342 C C4 . NAG Q 6 . ? 8.496 -45.070 -49.959 1.00 88.37 ? 616 NAG A C4 1 HETATM 4343 C C5 . NAG Q 6 . ? 7.418 -45.902 -49.281 1.00 87.84 ? 616 NAG A C5 1 HETATM 4344 C C6 . NAG Q 6 . ? 6.407 -46.405 -50.321 1.00 88.04 ? 616 NAG A C6 1 HETATM 4345 C C7 . NAG Q 6 . ? 12.143 -46.611 -46.890 1.00 87.92 ? 616 NAG A C7 1 HETATM 4346 C C8 . NAG Q 6 . ? 13.410 -46.935 -47.649 1.00 87.55 ? 616 NAG A C8 1 HETATM 4347 N N2 . NAG Q 6 . ? 11.270 -45.706 -47.399 1.00 86.70 ? 616 NAG A N2 1 HETATM 4348 O O3 . NAG Q 6 . ? 10.656 -44.085 -49.702 1.00 88.93 ? 616 NAG A O3 1 HETATM 4349 O O4 . NAG Q 6 . ? 7.902 -43.914 -50.519 1.00 89.35 ? 616 NAG A O4 1 HETATM 4350 O O5 . NAG Q 6 . ? 8.029 -46.988 -48.597 1.00 86.60 ? 616 NAG A O5 1 HETATM 4351 O O6 . NAG Q 6 . ? 6.101 -45.404 -51.273 1.00 86.57 ? 616 NAG A O6 1 HETATM 4352 O O7 . NAG Q 6 . ? 11.965 -47.169 -45.803 1.00 88.65 ? 616 NAG A O7 1 HETATM 4353 C C1 . NAG R 6 . ? 1.709 -52.117 -26.633 1.00 67.94 ? 617 NAG A C1 1 HETATM 4354 C C2 . NAG R 6 . ? 1.434 -51.833 -25.163 1.00 73.19 ? 617 NAG A C2 1 HETATM 4355 C C3 . NAG R 6 . ? 1.858 -52.993 -24.305 1.00 74.12 ? 617 NAG A C3 1 HETATM 4356 C C4 . NAG R 6 . ? 1.153 -54.257 -24.729 1.00 74.27 ? 617 NAG A C4 1 HETATM 4357 C C5 . NAG R 6 . ? 1.186 -54.481 -26.241 1.00 71.51 ? 617 NAG A C5 1 HETATM 4358 C C6 . NAG R 6 . ? 0.014 -55.422 -26.493 1.00 70.81 ? 617 NAG A C6 1 HETATM 4359 C C7 . NAG R 6 . ? 1.434 -49.671 -24.159 1.00 78.90 ? 617 NAG A C7 1 HETATM 4360 C C8 . NAG R 6 . ? 0.462 -50.042 -23.060 1.00 78.00 ? 617 NAG A C8 1 HETATM 4361 N N2 . NAG R 6 . ? 2.143 -50.674 -24.672 1.00 75.94 ? 617 NAG A N2 1 HETATM 4362 O O3 . NAG R 6 . ? 1.472 -52.714 -22.984 1.00 75.71 ? 617 NAG A O3 1 HETATM 4363 O O4 . NAG R 6 . ? 1.798 -55.301 -24.019 1.00 77.75 ? 617 NAG A O4 1 HETATM 4364 O O5 . NAG R 6 . ? 1.000 -53.301 -27.015 1.00 69.90 ? 617 NAG A O5 1 HETATM 4365 O O6 . NAG R 6 . ? 0.140 -56.167 -27.677 1.00 69.71 ? 617 NAG A O6 1 HETATM 4366 O O7 . NAG R 6 . ? 1.550 -48.506 -24.579 1.00 81.13 ? 617 NAG A O7 1 HETATM 4367 C C1 . NAG S 6 . ? 0.903 -56.368 -23.661 1.00 78.81 ? 618 NAG A C1 1 HETATM 4368 C C2 . NAG S 6 . ? 1.390 -57.628 -24.356 1.00 79.54 ? 618 NAG A C2 1 HETATM 4369 C C3 . NAG S 6 . ? 0.165 -58.506 -24.354 1.00 81.45 ? 618 NAG A C3 1 HETATM 4370 C C4 . NAG S 6 . ? 0.213 -59.026 -22.914 1.00 81.70 ? 618 NAG A C4 1 HETATM 4371 C C5 . NAG S 6 . ? 0.027 -57.830 -21.933 1.00 81.33 ? 618 NAG A C5 1 HETATM 4372 C C6 . NAG S 6 . ? 0.350 -58.256 -20.496 1.00 80.41 ? 618 NAG A C6 1 HETATM 4373 C C7 . NAG S 6 . ? 2.436 -58.384 -26.438 1.00 76.80 ? 618 NAG A C7 1 HETATM 4374 C C8 . NAG S 6 . ? 1.454 -59.340 -27.073 1.00 75.87 ? 618 NAG A C8 1 HETATM 4375 N N2 . NAG S 6 . ? 1.936 -57.403 -25.675 1.00 78.78 ? 618 NAG A N2 1 HETATM 4376 O O3 . NAG S 6 . ? 0.185 -59.478 -25.385 1.00 82.99 ? 618 NAG A O3 1 HETATM 4377 O O4 . NAG S 6 . ? -0.730 -60.065 -22.712 1.00 81.93 ? 618 NAG A O4 1 HETATM 4378 O O5 . NAG S 6 . ? 0.769 -56.636 -22.264 1.00 79.84 ? 618 NAG A O5 1 HETATM 4379 O O6 . NAG S 6 . ? 0.221 -59.662 -20.363 1.00 78.22 ? 618 NAG A O6 1 HETATM 4380 O O7 . NAG S 6 . ? 3.644 -58.496 -26.640 1.00 73.74 ? 618 NAG A O7 1 HETATM 4381 C C1 . FUL T 7 . ? -1.172 -56.212 -28.268 1.00 69.39 ? 619 FUL A C1 1 HETATM 4382 C C2 . FUL T 7 . ? -2.258 -56.865 -27.447 1.00 68.26 ? 619 FUL A C2 1 HETATM 4383 O O2 . FUL T 7 . ? -2.000 -56.747 -26.071 1.00 67.49 ? 619 FUL A O2 1 HETATM 4384 C C3 . FUL T 7 . ? -3.455 -56.015 -27.844 1.00 68.37 ? 619 FUL A C3 1 HETATM 4385 O O3 . FUL T 7 . ? -4.633 -56.449 -27.212 1.00 69.47 ? 619 FUL A O3 1 HETATM 4386 C C4 . FUL T 7 . ? -3.616 -55.989 -29.365 1.00 68.44 ? 619 FUL A C4 1 HETATM 4387 O O4 . FUL T 7 . ? -4.313 -57.132 -29.798 1.00 68.77 ? 619 FUL A O4 1 HETATM 4388 C C5 . FUL T 7 . ? -2.295 -55.888 -30.133 1.00 68.58 ? 619 FUL A C5 1 HETATM 4389 C C6 . FUL T 7 . ? -2.474 -56.215 -31.605 1.00 69.40 ? 619 FUL A C6 1 HETATM 4390 O O5 . FUL T 7 . ? -1.306 -56.715 -29.572 1.00 69.24 ? 619 FUL A O5 1 HETATM 4391 O O . HOH U 8 . ? -25.827 -7.127 -35.799 1.00 50.70 ? 701 HOH A O 1 HETATM 4392 O O . HOH U 8 . ? -19.527 -28.948 -3.295 1.00 39.32 ? 702 HOH A O 1 HETATM 4393 O O . HOH U 8 . ? -6.057 -19.860 -5.982 1.00 36.20 ? 703 HOH A O 1 HETATM 4394 O O . HOH U 8 . ? -25.063 -16.649 1.932 1.00 26.21 ? 704 HOH A O 1 HETATM 4395 O O . HOH U 8 . ? -41.644 -22.525 -30.819 1.00 47.29 ? 705 HOH A O 1 HETATM 4396 O O . HOH U 8 . ? -23.175 -21.519 -56.181 1.00 39.62 ? 706 HOH A O 1 HETATM 4397 O O . HOH U 8 . ? -34.569 -36.036 -12.229 1.00 39.08 ? 707 HOH A O 1 HETATM 4398 O O . HOH U 8 . ? -4.820 -15.282 -18.657 1.00 30.36 ? 708 HOH A O 1 HETATM 4399 O O . HOH U 8 . ? -6.693 -13.261 -13.430 1.00 48.14 ? 709 HOH A O 1 HETATM 4400 O O . HOH U 8 . ? 5.819 -42.667 -40.237 1.00 54.39 ? 710 HOH A O 1 HETATM 4401 O O . HOH U 8 . ? -26.400 -45.902 -42.606 1.00 35.61 ? 711 HOH A O 1 HETATM 4402 O O . HOH U 8 . ? -21.317 -26.568 -60.241 1.00 57.71 ? 712 HOH A O 1 HETATM 4403 O O . HOH U 8 . ? 1.334 -36.824 -27.608 1.00 50.24 ? 713 HOH A O 1 HETATM 4404 O O . HOH U 8 . ? -27.954 -53.592 -14.554 1.00 55.87 ? 714 HOH A O 1 HETATM 4405 O O . HOH U 8 . ? -24.768 -43.348 -24.884 1.00 28.30 ? 715 HOH A O 1 HETATM 4406 O O . HOH U 8 . ? -11.724 -12.376 -32.044 1.00 45.79 ? 716 HOH A O 1 HETATM 4407 O O . HOH U 8 . ? -24.843 -53.485 -5.887 1.00 33.96 ? 717 HOH A O 1 HETATM 4408 O O . HOH U 8 . ? -36.840 -32.136 -25.963 1.00 48.47 ? 718 HOH A O 1 HETATM 4409 O O . HOH U 8 . ? -17.361 -32.086 -47.190 1.00 30.19 ? 719 HOH A O 1 HETATM 4410 O O . HOH U 8 . ? -9.464 -44.595 -47.733 1.00 37.05 ? 720 HOH A O 1 HETATM 4411 O O . HOH U 8 . ? -30.906 -10.052 -18.755 1.00 26.08 ? 721 HOH A O 1 HETATM 4412 O O . HOH U 8 . ? -10.375 -24.038 -6.705 1.00 25.77 ? 722 HOH A O 1 HETATM 4413 O O . HOH U 8 . ? -14.919 -20.715 -47.616 1.00 51.47 ? 723 HOH A O 1 HETATM 4414 O O . HOH U 8 . ? -28.426 -22.863 -3.516 1.00 49.89 ? 724 HOH A O 1 HETATM 4415 O O . HOH U 8 . ? -34.159 -44.720 -26.907 1.00 42.86 ? 725 HOH A O 1 HETATM 4416 O O . HOH U 8 . ? -30.212 -30.838 -55.850 1.00 56.38 ? 726 HOH A O 1 HETATM 4417 O O . HOH U 8 . ? -21.172 -32.259 -18.923 1.00 17.06 ? 727 HOH A O 1 HETATM 4418 O O . HOH U 8 . ? -11.571 -47.326 -28.282 1.00 56.29 ? 728 HOH A O 1 HETATM 4419 O O . HOH U 8 . ? -35.097 -32.211 -10.367 1.00 45.64 ? 729 HOH A O 1 HETATM 4420 O O . HOH U 8 . ? -43.354 -23.270 -28.431 1.00 45.01 ? 730 HOH A O 1 HETATM 4421 O O . HOH U 8 . ? -21.666 -35.717 -28.977 1.00 14.16 ? 731 HOH A O 1 HETATM 4422 O O . HOH U 8 . ? -16.021 -45.108 -46.892 1.00 36.15 ? 732 HOH A O 1 HETATM 4423 O O . HOH U 8 . ? -28.335 -30.438 -33.437 1.00 24.40 ? 733 HOH A O 1 HETATM 4424 O O . HOH U 8 . ? -31.793 -52.558 -22.875 1.00 32.16 ? 734 HOH A O 1 HETATM 4425 O O . HOH U 8 . ? 0.600 -61.433 -18.566 1.00 62.54 ? 735 HOH A O 1 HETATM 4426 O O . HOH U 8 . ? -25.022 -34.846 -38.395 1.00 24.90 ? 736 HOH A O 1 HETATM 4427 O O . HOH U 8 . ? -11.753 -44.006 -47.814 1.00 32.56 ? 737 HOH A O 1 HETATM 4428 O O . HOH U 8 . ? -20.225 -26.697 -3.881 1.00 44.51 ? 738 HOH A O 1 HETATM 4429 O O . HOH U 8 . ? -7.044 -44.913 -15.243 1.00 39.93 ? 739 HOH A O 1 HETATM 4430 O O . HOH U 8 . ? -9.573 -14.381 -13.381 1.00 24.26 ? 740 HOH A O 1 HETATM 4431 O O . HOH U 8 . ? -16.886 -13.493 -42.741 1.00 39.13 ? 741 HOH A O 1 HETATM 4432 O O . HOH U 8 . ? -3.094 -41.209 -45.936 1.00 49.81 ? 742 HOH A O 1 HETATM 4433 O O . HOH U 8 . ? 0.672 -22.249 -27.439 1.00 26.32 ? 743 HOH A O 1 HETATM 4434 O O . HOH U 8 . ? -8.397 -25.124 -3.655 1.00 35.49 ? 744 HOH A O 1 HETATM 4435 O O . HOH U 8 . ? -7.478 -46.690 -22.895 1.00 39.80 ? 745 HOH A O 1 HETATM 4436 O O . HOH U 8 . ? -39.529 -27.234 -30.366 1.00 43.52 ? 746 HOH A O 1 HETATM 4437 O O . HOH U 8 . ? -25.472 -28.524 -33.111 1.00 22.17 ? 747 HOH A O 1 HETATM 4438 O O . HOH U 8 . ? -20.305 -8.823 -40.227 1.00 49.49 ? 748 HOH A O 1 HETATM 4439 O O . HOH U 8 . ? -10.370 -50.166 -25.246 1.00 35.52 ? 749 HOH A O 1 HETATM 4440 O O . HOH U 8 . ? -3.806 -37.822 -32.607 1.00 22.27 ? 750 HOH A O 1 HETATM 4441 O O . HOH U 8 . ? -29.426 -39.671 -30.868 1.00 53.88 ? 751 HOH A O 1 HETATM 4442 O O . HOH U 8 . ? -24.754 -6.174 -28.459 1.00 33.42 ? 752 HOH A O 1 HETATM 4443 O O . HOH U 8 . ? -11.069 -42.746 -13.422 1.00 42.87 ? 753 HOH A O 1 HETATM 4444 O O . HOH U 8 . ? -23.549 -55.458 -5.224 1.00 52.45 ? 754 HOH A O 1 HETATM 4445 O O . HOH U 8 . ? -34.000 -31.086 -32.361 0.50 26.57 ? 755 HOH A O 1 HETATM 4446 O O . HOH U 8 . ? -37.584 -28.442 -11.279 1.00 37.53 ? 756 HOH A O 1 HETATM 4447 O O . HOH U 8 . ? -10.932 -37.526 6.461 1.00 59.36 ? 757 HOH A O 1 HETATM 4448 O O . HOH U 8 . ? 1.980 -26.245 -10.192 1.00 67.47 ? 758 HOH A O 1 HETATM 4449 O O . HOH U 8 . ? -28.054 -18.191 -13.337 1.00 38.19 ? 759 HOH A O 1 HETATM 4450 O O . HOH U 8 . ? -25.138 -31.451 -40.323 1.00 32.06 ? 760 HOH A O 1 HETATM 4451 O O . HOH U 8 . ? -20.930 -8.738 -32.982 1.00 46.01 ? 761 HOH A O 1 HETATM 4452 O O . HOH U 8 . ? -23.329 -39.426 -31.616 1.00 31.53 ? 762 HOH A O 1 HETATM 4453 O O . HOH U 8 . ? -32.770 -49.646 -29.964 1.00 32.72 ? 763 HOH A O 1 HETATM 4454 O O . HOH U 8 . ? -22.003 -42.871 -7.092 1.00 35.88 ? 764 HOH A O 1 HETATM 4455 O O . HOH U 8 . ? -33.577 -41.903 -27.701 1.00 49.48 ? 765 HOH A O 1 HETATM 4456 O O . HOH U 8 . ? -30.361 -23.696 -29.035 1.00 26.40 ? 766 HOH A O 1 HETATM 4457 O O . HOH U 8 . ? -13.525 -25.404 0.068 1.00 33.71 ? 767 HOH A O 1 HETATM 4458 O O . HOH U 8 . ? -31.025 -6.680 -11.812 1.00 41.38 ? 768 HOH A O 1 HETATM 4459 O O . HOH U 8 . ? -10.098 -26.462 -5.501 1.00 33.96 ? 769 HOH A O 1 HETATM 4460 O O . HOH U 8 . ? 0.624 -32.305 -39.343 1.00 28.22 ? 770 HOH A O 1 HETATM 4461 O O . HOH U 8 . ? -6.346 -22.013 -44.582 1.00 70.24 ? 771 HOH A O 1 HETATM 4462 O O . HOH U 8 . ? -32.965 -15.080 -41.101 1.00 37.18 ? 772 HOH A O 1 HETATM 4463 O O . HOH U 8 . ? -11.352 -45.238 -26.853 1.00 49.82 ? 773 HOH A O 1 HETATM 4464 O O . HOH U 8 . ? -25.752 -23.681 -4.030 1.00 35.08 ? 774 HOH A O 1 HETATM 4465 O O . HOH U 8 . ? 1.049 -37.082 -33.837 1.00 28.92 ? 775 HOH A O 1 HETATM 4466 O O . HOH U 8 . ? -8.450 -52.106 -5.475 1.00 50.47 ? 776 HOH A O 1 HETATM 4467 O O . HOH U 8 . ? -2.049 -39.753 -49.365 1.00 83.16 ? 777 HOH A O 1 HETATM 4468 O O . HOH U 8 . ? -11.991 -15.721 -7.320 1.00 19.94 ? 778 HOH A O 1 HETATM 4469 O O . HOH U 8 . ? -9.695 -40.067 -41.965 1.00 19.71 ? 779 HOH A O 1 HETATM 4470 O O . HOH U 8 . ? -10.933 -47.658 4.644 1.00 65.38 ? 780 HOH A O 1 HETATM 4471 O O . HOH U 8 . ? -22.562 -38.369 -28.629 1.00 26.67 ? 781 HOH A O 1 HETATM 4472 O O . HOH U 8 . ? -27.819 -9.630 -23.672 1.00 26.29 ? 782 HOH A O 1 HETATM 4473 O O . HOH U 8 . ? -26.586 -8.778 -42.280 1.00 50.09 ? 783 HOH A O 1 HETATM 4474 O O . HOH U 8 . ? -12.528 -45.792 -30.450 1.00 45.49 ? 784 HOH A O 1 HETATM 4475 O O . HOH U 8 . ? -19.012 -16.852 -0.717 1.00 33.62 ? 785 HOH A O 1 HETATM 4476 O O . HOH U 8 . ? -6.958 -24.970 -40.562 1.00 51.16 ? 786 HOH A O 1 HETATM 4477 O O . HOH U 8 . ? -9.710 -14.268 -39.020 1.00 52.17 ? 787 HOH A O 1 HETATM 4478 O O . HOH U 8 . ? -5.828 -31.281 2.820 1.00 47.96 ? 788 HOH A O 1 HETATM 4479 O O . HOH U 8 . ? -14.770 -11.022 -5.944 1.00 40.53 ? 789 HOH A O 1 HETATM 4480 O O . HOH U 8 . ? 2.338 -53.480 -36.827 1.00 47.63 ? 790 HOH A O 1 HETATM 4481 O O . HOH U 8 . ? -19.693 -29.791 -32.993 1.00 19.69 ? 791 HOH A O 1 HETATM 4482 O O . HOH U 8 . ? 5.235 -52.016 -23.574 1.00 61.02 ? 792 HOH A O 1 HETATM 4483 O O . HOH U 8 . ? -12.579 -25.542 -47.229 1.00 50.78 ? 793 HOH A O 1 HETATM 4484 O O . HOH U 8 . ? -22.120 -38.694 -14.466 1.00 24.00 ? 794 HOH A O 1 HETATM 4485 O O . HOH U 8 . ? 0.326 -27.332 -16.663 1.00 32.69 ? 795 HOH A O 1 HETATM 4486 O O . HOH U 8 . ? 0.065 -21.119 -15.863 1.00 32.45 ? 796 HOH A O 1 HETATM 4487 O O . HOH U 8 . ? -20.658 -28.786 -17.022 1.00 18.84 ? 797 HOH A O 1 HETATM 4488 O O . HOH U 8 . ? -28.295 -32.415 -21.824 1.00 24.07 ? 798 HOH A O 1 HETATM 4489 O O . HOH U 8 . ? -35.170 -13.824 -32.721 1.00 35.25 ? 799 HOH A O 1 HETATM 4490 O O . HOH U 8 . ? -17.058 -34.656 -46.067 1.00 28.88 ? 800 HOH A O 1 HETATM 4491 O O . HOH U 8 . ? 2.541 -53.778 -29.523 1.00 58.51 ? 801 HOH A O 1 HETATM 4492 O O . HOH U 8 . ? -36.018 -32.498 -23.500 1.00 46.01 ? 802 HOH A O 1 HETATM 4493 O O . HOH U 8 . ? -21.599 -43.265 -31.174 1.00 22.46 ? 803 HOH A O 1 HETATM 4494 O O . HOH U 8 . ? -37.349 -28.578 -25.962 1.00 36.69 ? 804 HOH A O 1 HETATM 4495 O O . HOH U 8 . ? -27.381 -48.132 -25.313 1.00 29.67 ? 805 HOH A O 1 HETATM 4496 O O . HOH U 8 . ? -14.221 -18.498 -36.679 1.00 21.13 ? 806 HOH A O 1 HETATM 4497 O O . HOH U 8 . ? -21.184 -40.330 -27.580 1.00 31.97 ? 807 HOH A O 1 HETATM 4498 O O . HOH U 8 . ? -4.787 -13.717 -6.881 1.00 55.06 ? 808 HOH A O 1 HETATM 4499 O O . HOH U 8 . ? -17.325 -35.556 -7.673 1.00 22.56 ? 809 HOH A O 1 HETATM 4500 O O . HOH U 8 . ? -29.216 -4.406 -17.426 1.00 37.88 ? 810 HOH A O 1 HETATM 4501 O O . HOH U 8 . ? -21.015 -32.864 -25.932 1.00 20.38 ? 811 HOH A O 1 HETATM 4502 O O . HOH U 8 . ? -13.100 -12.361 -7.699 1.00 35.47 ? 812 HOH A O 1 HETATM 4503 O O . HOH U 8 . ? -21.078 -49.415 -24.743 1.00 40.82 ? 813 HOH A O 1 HETATM 4504 O O . HOH U 8 . ? -18.147 -13.488 -45.802 1.00 45.02 ? 814 HOH A O 1 HETATM 4505 O O . HOH U 8 . ? -11.888 -40.517 -43.478 1.00 25.78 ? 815 HOH A O 1 HETATM 4506 O O . HOH U 8 . ? -0.930 -33.227 -37.365 1.00 27.34 ? 816 HOH A O 1 HETATM 4507 O O . HOH U 8 . ? 7.675 -49.493 -24.302 1.00 88.67 ? 817 HOH A O 1 HETATM 4508 O O . HOH U 8 . ? -39.883 -18.851 -48.006 1.00 62.94 ? 818 HOH A O 1 HETATM 4509 O O . HOH U 8 . ? -28.505 -9.252 -18.681 1.00 27.36 ? 819 HOH A O 1 HETATM 4510 O O . HOH U 8 . ? 7.056 -39.875 -39.634 1.00 69.82 ? 820 HOH A O 1 HETATM 4511 O O . HOH U 8 . ? -30.359 -41.927 -45.395 1.00 38.54 ? 821 HOH A O 1 HETATM 4512 O O . HOH U 8 . ? -22.243 -48.485 -1.142 1.00 37.91 ? 822 HOH A O 1 HETATM 4513 O O . HOH U 8 . ? -39.673 -8.657 -14.213 1.00 72.39 ? 823 HOH A O 1 HETATM 4514 O O . HOH U 8 . ? -14.526 -9.827 -18.615 1.00 31.64 ? 824 HOH A O 1 HETATM 4515 O O . HOH U 8 . ? -4.449 -36.692 -11.181 1.00 33.09 ? 825 HOH A O 1 HETATM 4516 O O . HOH U 8 . ? -24.552 -51.736 -15.725 1.00 44.16 ? 826 HOH A O 1 HETATM 4517 O O . HOH U 8 . ? -20.737 -38.026 -7.914 1.00 21.43 ? 827 HOH A O 1 HETATM 4518 O O . HOH U 8 . ? -21.857 -17.515 -0.055 1.00 31.89 ? 828 HOH A O 1 HETATM 4519 O O . HOH U 8 . ? -29.083 -8.737 -11.960 1.00 36.52 ? 829 HOH A O 1 HETATM 4520 O O . HOH U 8 . ? -31.646 -27.202 -8.659 1.00 34.98 ? 830 HOH A O 1 HETATM 4521 O O . HOH U 8 . ? -25.006 -10.463 -31.244 1.00 37.53 ? 831 HOH A O 1 HETATM 4522 O O . HOH U 8 . ? -31.565 -31.140 -8.682 1.00 31.14 ? 832 HOH A O 1 HETATM 4523 O O . HOH U 8 . ? -17.529 -13.836 -28.979 1.00 26.38 ? 833 HOH A O 1 HETATM 4524 O O . HOH U 8 . ? -17.712 -10.224 -12.110 1.00 37.35 ? 834 HOH A O 1 HETATM 4525 O O . HOH U 8 . ? -10.105 -33.546 -46.931 1.00 33.81 ? 835 HOH A O 1 HETATM 4526 O O . HOH U 8 . ? -35.135 -46.666 -29.418 1.00 46.99 ? 836 HOH A O 1 HETATM 4527 O O . HOH U 8 . ? -23.535 -38.760 -20.069 1.00 37.59 ? 837 HOH A O 1 HETATM 4528 O O . HOH U 8 . ? 0.981 -46.467 -10.627 1.00 34.49 ? 838 HOH A O 1 HETATM 4529 O O . HOH U 8 . ? -15.299 -45.038 -32.398 1.00 38.92 ? 839 HOH A O 1 HETATM 4530 O O . HOH U 8 . ? -22.354 -8.902 -41.025 1.00 59.90 ? 840 HOH A O 1 HETATM 4531 O O . HOH U 8 . ? -4.333 -17.838 -35.840 1.00 43.89 ? 841 HOH A O 1 HETATM 4532 O O . HOH U 8 . ? -12.612 -44.049 -36.674 1.00 25.04 ? 842 HOH A O 1 HETATM 4533 O O . HOH U 8 . ? -24.269 -29.955 -4.188 1.00 42.11 ? 843 HOH A O 1 HETATM 4534 O O . HOH U 8 . ? -14.623 -40.705 -37.673 1.00 19.89 ? 844 HOH A O 1 HETATM 4535 O O . HOH U 8 . ? -12.144 -11.730 -37.139 1.00 41.85 ? 845 HOH A O 1 HETATM 4536 O O . HOH U 8 . ? -20.965 -40.093 -6.322 1.00 26.82 ? 846 HOH A O 1 HETATM 4537 O O . HOH U 8 . ? -7.052 -28.043 -4.005 1.00 44.67 ? 847 HOH A O 1 HETATM 4538 O O . HOH U 8 . ? -35.166 -21.659 -11.156 1.00 41.56 ? 848 HOH A O 1 HETATM 4539 O O . HOH U 8 . ? -13.108 -11.125 -1.712 1.00 35.83 ? 849 HOH A O 1 HETATM 4540 O O . HOH U 8 . ? -21.153 -51.963 -14.483 1.00 34.56 ? 850 HOH A O 1 HETATM 4541 O O . HOH U 8 . ? -12.460 -30.033 0.451 1.00 53.54 ? 851 HOH A O 1 HETATM 4542 O O . HOH U 8 . ? -25.073 -11.561 -12.775 1.00 39.20 ? 852 HOH A O 1 HETATM 4543 O O . HOH U 8 . ? 2.632 -35.342 -36.821 1.00 56.53 ? 853 HOH A O 1 HETATM 4544 O O . HOH U 8 . ? -29.403 -7.297 -36.239 1.00 44.45 ? 854 HOH A O 1 HETATM 4545 O O . HOH U 8 . ? -6.840 -35.442 -12.146 1.00 23.01 ? 855 HOH A O 1 HETATM 4546 O O . HOH U 8 . ? -16.021 -17.755 -10.898 1.00 16.77 ? 856 HOH A O 1 HETATM 4547 O O . HOH U 8 . ? -22.495 -42.920 -28.804 1.00 31.33 ? 857 HOH A O 1 HETATM 4548 O O . HOH U 8 . ? -12.557 -19.577 1.344 1.00 37.69 ? 858 HOH A O 1 HETATM 4549 O O . HOH U 8 . ? -39.088 -25.420 -35.277 1.00 41.82 ? 859 HOH A O 1 HETATM 4550 O O . HOH U 8 . ? -6.068 -40.782 -24.604 1.00 36.23 ? 860 HOH A O 1 HETATM 4551 O O . HOH U 8 . ? 6.837 -18.031 -19.771 1.00 31.82 ? 861 HOH A O 1 HETATM 4552 O O . HOH U 8 . ? -30.083 -40.525 -41.848 1.00 39.76 ? 862 HOH A O 1 HETATM 4553 O O . HOH U 8 . ? -15.608 -35.375 -3.769 1.00 31.03 ? 863 HOH A O 1 HETATM 4554 O O . HOH U 8 . ? -29.508 -32.070 -15.351 1.00 28.55 ? 864 HOH A O 1 HETATM 4555 O O . HOH U 8 . ? -2.750 -24.881 -35.749 1.00 41.98 ? 865 HOH A O 1 HETATM 4556 O O . HOH U 8 . ? -30.175 -13.002 -6.523 1.00 60.53 ? 866 HOH A O 1 HETATM 4557 O O . HOH U 8 . ? -27.042 -43.888 12.784 1.00 35.62 ? 867 HOH A O 1 HETATM 4558 O O . HOH U 8 . ? -11.644 -55.486 -10.953 1.00 54.75 ? 868 HOH A O 1 HETATM 4559 O O . HOH U 8 . ? -8.365 -35.525 -45.648 1.00 32.43 ? 869 HOH A O 1 HETATM 4560 O O . HOH U 8 . ? -3.628 -30.120 -14.198 1.00 46.37 ? 870 HOH A O 1 HETATM 4561 O O . HOH U 8 . ? -7.432 -29.321 -9.108 1.00 26.78 ? 871 HOH A O 1 HETATM 4562 O O . HOH U 8 . ? -4.045 -40.857 -31.209 1.00 34.63 ? 872 HOH A O 1 HETATM 4563 O O . HOH U 8 . ? -3.950 -35.025 -20.659 1.00 34.95 ? 873 HOH A O 1 HETATM 4564 O O . HOH U 8 . ? -20.712 -48.158 -36.324 1.00 31.31 ? 874 HOH A O 1 HETATM 4565 O O . HOH U 8 . ? -14.668 -27.903 -17.574 1.00 23.67 ? 875 HOH A O 1 HETATM 4566 O O . HOH U 8 . ? -13.081 -23.176 -6.513 1.00 19.28 ? 876 HOH A O 1 HETATM 4567 O O . HOH U 8 . ? -15.724 -36.620 -29.255 1.00 20.25 ? 877 HOH A O 1 HETATM 4568 O O . HOH U 8 . ? 0.632 -13.889 -24.733 1.00 54.68 ? 878 HOH A O 1 HETATM 4569 O O . HOH U 8 . ? -33.225 -46.366 -15.873 1.00 49.11 ? 879 HOH A O 1 HETATM 4570 O O . HOH U 8 . ? -6.914 -57.773 -28.793 1.00 52.06 ? 880 HOH A O 1 HETATM 4571 O O . HOH U 8 . ? -2.740 -13.729 -27.033 1.00 34.06 ? 881 HOH A O 1 HETATM 4572 O O . HOH U 8 . ? -14.158 -39.556 -42.243 1.00 23.89 ? 882 HOH A O 1 HETATM 4573 O O . HOH U 8 . ? -46.283 -21.049 -24.827 1.00 63.53 ? 883 HOH A O 1 HETATM 4574 O O . HOH U 8 . ? -10.631 -38.491 -52.124 1.00 43.30 ? 884 HOH A O 1 HETATM 4575 O O . HOH U 8 . ? -8.844 -54.591 -24.804 1.00 50.43 ? 885 HOH A O 1 HETATM 4576 O O . HOH U 8 . ? -17.515 -51.210 -8.080 1.00 29.90 ? 886 HOH A O 1 HETATM 4577 O O . HOH U 8 . ? -2.777 -43.594 -33.083 1.00 33.29 ? 887 HOH A O 1 HETATM 4578 O O . HOH U 8 . ? -21.528 -50.779 -26.858 1.00 46.02 ? 888 HOH A O 1 HETATM 4579 O O . HOH U 8 . ? -28.205 -31.824 -6.154 1.00 41.95 ? 889 HOH A O 1 HETATM 4580 O O . HOH U 8 . ? 6.524 -47.286 -53.438 1.00 71.27 ? 890 HOH A O 1 HETATM 4581 O O . HOH U 8 . ? -29.455 -42.944 -1.998 1.00 59.00 ? 891 HOH A O 1 HETATM 4582 O O . HOH U 8 . ? -1.953 -34.644 -43.538 1.00 45.06 ? 892 HOH A O 1 HETATM 4583 O O . HOH U 8 . ? -4.761 -44.659 -51.619 1.00 56.27 ? 893 HOH A O 1 HETATM 4584 O O . HOH U 8 . ? -20.162 -50.114 -32.395 1.00 47.71 ? 894 HOH A O 1 HETATM 4585 O O . HOH U 8 . ? 0.473 -25.530 -29.573 1.00 37.05 ? 895 HOH A O 1 HETATM 4586 O O . HOH U 8 . ? -19.912 -36.789 -36.506 1.00 25.44 ? 896 HOH A O 1 HETATM 4587 O O . HOH U 8 . ? -31.590 -19.942 -9.013 1.00 58.50 ? 897 HOH A O 1 HETATM 4588 O O . HOH U 8 . ? -42.473 -22.434 -25.079 1.00 54.08 ? 898 HOH A O 1 HETATM 4589 O O . HOH U 8 . ? 2.192 -50.315 -13.689 1.00 70.60 ? 899 HOH A O 1 HETATM 4590 O O . HOH U 8 . ? -24.591 -10.655 -6.181 1.00 45.07 ? 900 HOH A O 1 HETATM 4591 O O . HOH U 8 . ? -1.278 -47.855 -25.049 1.00 38.39 ? 901 HOH A O 1 HETATM 4592 O O . HOH U 8 . ? -23.827 -16.210 -2.413 1.00 22.48 ? 902 HOH A O 1 HETATM 4593 O O . HOH U 8 . ? -11.660 -31.405 -17.192 1.00 24.59 ? 903 HOH A O 1 HETATM 4594 O O . HOH U 8 . ? -24.382 -42.313 -5.695 1.00 39.15 ? 904 HOH A O 1 HETATM 4595 O O . HOH U 8 . ? -7.362 -27.325 -41.000 1.00 34.62 ? 905 HOH A O 1 HETATM 4596 O O . HOH U 8 . ? -10.449 -21.320 2.563 1.00 70.77 ? 906 HOH A O 1 HETATM 4597 O O . HOH U 8 . ? -21.671 -51.534 1.829 1.00 52.88 ? 907 HOH A O 1 HETATM 4598 O O . HOH U 8 . ? -28.972 -45.870 -31.093 1.00 45.99 ? 908 HOH A O 1 HETATM 4599 O O . HOH U 8 . ? -9.852 -25.160 1.385 1.00 43.02 ? 909 HOH A O 1 HETATM 4600 O O . HOH U 8 . ? -10.981 -22.607 -45.837 1.00 60.24 ? 910 HOH A O 1 HETATM 4601 O O . HOH U 8 . ? -20.466 -7.582 -28.995 1.00 41.89 ? 911 HOH A O 1 HETATM 4602 O O . HOH U 8 . ? -0.600 -32.067 -11.586 1.00 49.74 ? 912 HOH A O 1 HETATM 4603 O O . HOH U 8 . ? -24.433 -42.799 -22.086 0.40 13.67 ? 913 HOH A O 1 HETATM 4604 O O . HOH U 8 . ? -36.181 -45.290 -22.539 1.00 37.23 ? 914 HOH A O 1 HETATM 4605 O O . HOH U 8 . ? -27.056 -39.356 3.921 1.00 73.22 ? 915 HOH A O 1 HETATM 4606 O O . HOH U 8 . ? -5.274 -35.312 -14.913 1.00 43.53 ? 916 HOH A O 1 HETATM 4607 O O . HOH U 8 . ? -41.219 -25.469 -10.929 1.00 37.16 ? 917 HOH A O 1 HETATM 4608 O O . HOH U 8 . ? -21.568 -37.784 -3.550 1.00 40.21 ? 918 HOH A O 1 HETATM 4609 O O . HOH U 8 . ? -34.527 -43.683 -9.400 1.00 39.18 ? 919 HOH A O 1 HETATM 4610 O O . HOH U 8 . ? -18.031 -44.027 -45.923 1.00 32.96 ? 920 HOH A O 1 HETATM 4611 O O . HOH U 8 . ? -9.003 -41.908 -17.283 1.00 25.94 ? 921 HOH A O 1 HETATM 4612 O O . HOH U 8 . ? -26.237 -55.029 -24.399 1.00 61.11 ? 922 HOH A O 1 HETATM 4613 O O . HOH U 8 . ? -17.597 -33.833 -3.341 1.00 41.09 ? 923 HOH A O 1 HETATM 4614 O O . HOH U 8 . ? 6.352 -15.901 -23.807 1.00 55.04 ? 924 HOH A O 1 HETATM 4615 O O . HOH U 8 . ? -0.228 -41.369 -11.619 1.00 52.83 ? 925 HOH A O 1 HETATM 4616 O O . HOH U 8 . ? -16.293 -49.726 6.210 1.00 42.60 ? 926 HOH A O 1 HETATM 4617 O O . HOH U 8 . ? -18.417 -58.254 -2.030 1.00 47.70 ? 927 HOH A O 1 HETATM 4618 O O . HOH U 8 . ? -38.543 -23.018 -45.484 1.00 39.70 ? 928 HOH A O 1 HETATM 4619 O O . HOH U 8 . ? -30.698 -36.755 -30.926 1.00 30.91 ? 929 HOH A O 1 HETATM 4620 O O . HOH U 8 . ? -9.577 -12.517 -30.413 1.00 41.06 ? 930 HOH A O 1 HETATM 4621 O O . HOH U 8 . ? -31.775 -44.537 -7.441 1.00 35.98 ? 931 HOH A O 1 HETATM 4622 O O . HOH U 8 . ? -15.207 -46.452 -30.122 1.00 48.40 ? 932 HOH A O 1 HETATM 4623 O O . HOH U 8 . ? -32.345 -33.275 -40.767 1.00 36.72 ? 933 HOH A O 1 HETATM 4624 O O . HOH U 8 . ? -18.784 -37.089 -9.450 1.00 28.20 ? 934 HOH A O 1 HETATM 4625 O O . HOH U 8 . ? -22.844 -26.239 -3.442 1.00 35.08 ? 935 HOH A O 1 HETATM 4626 O O . HOH U 8 . ? -8.789 -42.631 -19.799 1.00 35.15 ? 936 HOH A O 1 HETATM 4627 O O . HOH U 8 . ? -11.382 -18.025 -0.661 1.00 32.69 ? 937 HOH A O 1 HETATM 4628 O O . HOH U 8 . ? -25.784 -41.268 -46.495 1.00 42.97 ? 938 HOH A O 1 HETATM 4629 O O . HOH U 8 . ? -5.907 -28.830 -42.681 1.00 36.31 ? 939 HOH A O 1 HETATM 4630 O O . HOH U 8 . ? -5.795 -25.174 -50.053 1.00 62.17 ? 940 HOH A O 1 HETATM 4631 O O . HOH U 8 . ? -28.481 -49.048 -27.830 1.00 41.41 ? 941 HOH A O 1 HETATM 4632 O O . HOH U 8 . ? -14.202 -22.818 1.283 1.00 24.63 ? 942 HOH A O 1 HETATM 4633 O O . HOH U 8 . ? -6.005 -10.158 -22.705 1.00 46.68 ? 943 HOH A O 1 HETATM 4634 O O . HOH U 8 . ? -11.997 -37.038 -0.117 1.00 56.42 ? 944 HOH A O 1 HETATM 4635 O O . HOH U 8 . ? -41.864 -15.479 -16.798 1.00 57.61 ? 945 HOH A O 1 HETATM 4636 O O . HOH U 8 . ? -19.315 -47.698 5.153 1.00 55.67 ? 946 HOH A O 1 HETATM 4637 O O . HOH U 8 . ? -18.856 -21.026 -60.253 1.00 72.15 ? 947 HOH A O 1 HETATM 4638 O O . HOH U 8 . ? -16.612 -56.088 1.362 1.00 38.12 ? 948 HOH A O 1 HETATM 4639 O O . HOH U 8 . ? 2.563 -50.767 -5.186 1.00 39.76 ? 949 HOH A O 1 HETATM 4640 O O . HOH U 8 . ? -26.821 -51.115 -15.750 1.00 41.97 ? 950 HOH A O 1 HETATM 4641 O O . HOH U 8 . ? -6.211 -32.779 -11.593 1.00 27.42 ? 951 HOH A O 1 HETATM 4642 O O . HOH U 8 . ? -44.115 -21.452 -31.820 1.00 56.03 ? 952 HOH A O 1 HETATM 4643 O O . HOH U 8 . ? -30.067 -45.178 -2.051 1.00 67.07 ? 953 HOH A O 1 HETATM 4644 O O . HOH U 8 . ? -36.535 -44.977 -25.996 1.00 58.51 ? 954 HOH A O 1 HETATM 4645 O O . HOH U 8 . ? -25.515 -12.551 -48.326 1.00 48.13 ? 955 HOH A O 1 HETATM 4646 O O . HOH U 8 . ? -10.322 -9.185 -12.354 1.00 53.67 ? 956 HOH A O 1 HETATM 4647 O O . HOH U 8 . ? -12.757 -48.336 -47.742 1.00 47.68 ? 957 HOH A O 1 HETATM 4648 O O . HOH U 8 . ? -15.092 -40.984 -40.287 1.00 21.00 ? 958 HOH A O 1 HETATM 4649 O O . HOH U 8 . ? -3.601 -43.445 -30.726 1.00 38.21 ? 959 HOH A O 1 HETATM 4650 O O . HOH U 8 . ? -32.273 -31.286 -51.670 1.00 56.17 ? 960 HOH A O 1 HETATM 4651 O O . HOH U 8 . ? -30.096 -35.764 -28.127 1.00 27.18 ? 961 HOH A O 1 HETATM 4652 O O . HOH U 8 . ? -40.896 -25.256 -37.962 1.00 42.69 ? 962 HOH A O 1 HETATM 4653 O O . HOH U 8 . ? -34.799 -12.084 -29.105 1.00 52.94 ? 963 HOH A O 1 HETATM 4654 O O . HOH U 8 . ? -1.349 -29.209 -44.532 1.00 50.80 ? 964 HOH A O 1 HETATM 4655 O O . HOH U 8 . ? -35.585 -41.984 -13.686 1.00 41.71 ? 965 HOH A O 1 HETATM 4656 O O . HOH U 8 . ? 0.848 -30.134 -43.297 1.00 58.60 ? 966 HOH A O 1 HETATM 4657 O O . HOH U 8 . ? -18.986 -32.357 -49.638 1.00 32.75 ? 967 HOH A O 1 HETATM 4658 O O . HOH U 8 . ? -15.733 -4.288 -28.897 1.00 45.22 ? 968 HOH A O 1 HETATM 4659 O O . HOH U 8 . ? -20.752 -40.293 -49.740 1.00 41.81 ? 969 HOH A O 1 HETATM 4660 O O . HOH U 8 . ? -16.323 -31.514 -0.579 1.00 61.79 ? 970 HOH A O 1 HETATM 4661 O O . HOH U 8 . ? 8.268 -44.609 -44.047 1.00 76.69 ? 971 HOH A O 1 HETATM 4662 O O . HOH U 8 . ? -2.296 -27.387 -29.078 1.00 66.58 ? 972 HOH A O 1 HETATM 4663 O O . HOH U 8 . ? -37.124 -13.250 -22.059 1.00 45.63 ? 973 HOH A O 1 HETATM 4664 O O . HOH U 8 . ? -18.647 -53.604 3.091 1.00 47.49 ? 974 HOH A O 1 HETATM 4665 O O . HOH U 8 . ? -31.162 -6.439 -38.237 1.00 54.98 ? 975 HOH A O 1 HETATM 4666 O O . HOH U 8 . ? -23.971 -3.682 -40.697 1.00 60.38 ? 976 HOH A O 1 HETATM 4667 O O . HOH U 8 . ? -15.361 -36.871 -1.645 1.00 42.66 ? 977 HOH A O 1 HETATM 4668 O O . HOH U 8 . ? 9.363 -46.053 -42.122 1.00 52.18 ? 978 HOH A O 1 HETATM 4669 O O . HOH U 8 . ? -11.242 -6.381 -16.692 1.00 53.59 ? 979 HOH A O 1 HETATM 4670 O O . HOH U 8 . ? -32.973 -51.021 -5.526 1.00 37.62 ? 980 HOH A O 1 HETATM 4671 O O . HOH U 8 . ? -32.530 -31.628 -33.727 0.50 24.22 ? 981 HOH A O 1 HETATM 4672 O O . HOH U 8 . ? -22.517 -6.783 -8.041 1.00 66.90 ? 982 HOH A O 1 HETATM 4673 O O . HOH U 8 . ? -26.606 -38.816 -5.464 1.00 53.15 ? 983 HOH A O 1 HETATM 4674 O O . HOH U 8 . ? -18.040 -12.968 -2.914 1.00 44.75 ? 984 HOH A O 1 HETATM 4675 O O . HOH U 8 . ? -27.582 -30.345 -52.162 1.00 48.23 ? 985 HOH A O 1 HETATM 4676 O O . HOH U 8 . ? -40.772 -14.333 -20.903 1.00 64.09 ? 986 HOH A O 1 HETATM 4677 O O . HOH U 8 . ? -15.170 -9.980 -9.493 1.00 34.89 ? 987 HOH A O 1 HETATM 4678 O O . HOH U 8 . ? -8.207 -17.215 0.485 1.00 62.46 ? 988 HOH A O 1 HETATM 4679 O O . HOH U 8 . ? -4.376 -41.962 -18.168 1.00 47.12 ? 989 HOH A O 1 HETATM 4680 O O . HOH U 8 . ? -41.720 -14.036 -37.523 1.00 64.16 ? 990 HOH A O 1 HETATM 4681 O O . HOH U 8 . ? -11.056 -13.144 -34.363 1.00 49.91 ? 991 HOH A O 1 HETATM 4682 O O . HOH U 8 . ? -37.181 -9.947 -18.362 1.00 59.09 ? 992 HOH A O 1 HETATM 4683 O O . HOH U 8 . ? -39.738 -25.267 -31.966 1.00 52.21 ? 993 HOH A O 1 HETATM 4684 O O . HOH U 8 . ? -8.626 -42.373 -54.003 1.00 39.68 ? 994 HOH A O 1 HETATM 4685 O O . HOH U 8 . ? -13.806 -28.197 0.299 1.00 49.52 ? 995 HOH A O 1 HETATM 4686 O O . HOH U 8 . ? -7.758 -45.597 -51.156 1.00 50.90 ? 996 HOH A O 1 HETATM 4687 O O . HOH U 8 . ? -16.371 -9.174 -13.915 1.00 46.34 ? 997 HOH A O 1 HETATM 4688 O O . HOH U 8 . ? 2.549 -48.204 -11.986 1.00 54.51 ? 998 HOH A O 1 HETATM 4689 O O . HOH U 8 . ? 2.502 -52.833 -7.571 1.00 42.68 ? 999 HOH A O 1 HETATM 4690 O O . HOH U 8 . ? -25.568 -8.664 -11.936 1.00 44.35 ? 1000 HOH A O 1 HETATM 4691 O O . HOH U 8 . ? 9.850 -30.884 -26.748 1.00 45.80 ? 1001 HOH A O 1 HETATM 4692 O O . HOH U 8 . ? 3.843 -36.516 -25.684 1.00 42.25 ? 1002 HOH A O 1 HETATM 4693 O O . HOH U 8 . ? 1.439 -16.777 -26.339 1.00 53.61 ? 1003 HOH A O 1 HETATM 4694 O O . HOH U 8 . ? -18.712 -42.484 -48.734 1.00 63.56 ? 1004 HOH A O 1 HETATM 4695 O O . HOH U 8 . ? -5.001 -46.183 -15.556 1.00 56.76 ? 1005 HOH A O 1 HETATM 4696 O O . HOH U 8 . ? -2.376 -48.141 -22.561 1.00 60.61 ? 1006 HOH A O 1 HETATM 4697 O O . HOH U 8 . ? 2.733 -14.837 -14.127 1.00 47.88 ? 1007 HOH A O 1 HETATM 4698 O O . HOH U 8 . ? -33.076 -47.356 -8.885 1.00 58.66 ? 1008 HOH A O 1 HETATM 4699 O O . HOH U 8 . ? -40.973 -18.830 -42.864 1.00 68.83 ? 1009 HOH A O 1 HETATM 4700 O O . HOH U 8 . ? -24.574 -41.007 -20.147 1.00 46.17 ? 1010 HOH A O 1 HETATM 4701 O O . HOH U 8 . ? -51.623 -26.445 -30.805 0.50 47.02 ? 1011 HOH A O 1 HETATM 4702 O O . HOH U 8 . ? -13.355 -8.781 -27.822 1.00 49.29 ? 1012 HOH A O 1 HETATM 4703 O O . HOH U 8 . ? -12.951 -22.181 -45.539 1.00 51.83 ? 1013 HOH A O 1 HETATM 4704 O O . HOH U 8 . ? -15.389 -17.157 1.806 1.00 32.55 ? 1014 HOH A O 1 HETATM 4705 O O . HOH U 8 . ? -36.900 -44.888 -17.604 1.00 74.70 ? 1015 HOH A O 1 HETATM 4706 O O . HOH U 8 . ? -19.153 -46.298 -27.634 1.00 46.05 ? 1016 HOH A O 1 HETATM 4707 O O . HOH U 8 . ? -32.195 -19.655 -11.880 1.00 47.76 ? 1017 HOH A O 1 HETATM 4708 O O . HOH U 8 . ? -22.940 -8.143 -6.261 1.00 71.98 ? 1018 HOH A O 1 HETATM 4709 O O . HOH U 8 . ? -36.994 -30.548 -10.595 1.00 47.93 ? 1019 HOH A O 1 HETATM 4710 O O . HOH U 8 . ? -23.357 -7.866 -30.097 1.00 43.30 ? 1020 HOH A O 1 HETATM 4711 O O . HOH U 8 . ? -2.409 -37.740 -12.644 1.00 42.90 ? 1021 HOH A O 1 HETATM 4712 O O . HOH U 8 . ? -41.974 -20.958 -41.688 1.00 46.87 ? 1022 HOH A O 1 HETATM 4713 O O . HOH U 8 . ? -29.391 -53.628 -18.906 1.00 47.46 ? 1023 HOH A O 1 HETATM 4714 O O . HOH U 8 . ? -17.366 -48.643 -21.891 1.00 46.90 ? 1024 HOH A O 1 HETATM 4715 O O . HOH U 8 . ? -37.185 -31.173 -32.833 1.00 53.90 ? 1025 HOH A O 1 HETATM 4716 O O . HOH U 8 . ? -5.964 -11.985 -33.706 1.00 53.34 ? 1026 HOH A O 1 HETATM 4717 O O . HOH U 8 . ? -23.144 -42.345 -48.181 1.00 52.60 ? 1027 HOH A O 1 HETATM 4718 O O . HOH U 8 . ? 2.707 -16.950 -13.190 1.00 48.89 ? 1028 HOH A O 1 HETATM 4719 O O . HOH U 8 . ? -32.124 -35.921 -26.880 1.00 31.62 ? 1029 HOH A O 1 HETATM 4720 O O . HOH U 8 . ? -38.499 -32.251 -30.827 1.00 53.43 ? 1030 HOH A O 1 HETATM 4721 O O . HOH U 8 . ? -24.728 -27.367 -1.521 1.00 62.91 ? 1031 HOH A O 1 HETATM 4722 O O . HOH U 8 . ? -15.684 -10.740 -43.335 1.00 45.72 ? 1032 HOH A O 1 HETATM 4723 O O . HOH U 8 . ? -34.184 -37.219 -28.548 1.00 52.91 ? 1033 HOH A O 1 HETATM 4724 O O . HOH U 8 . ? 0.674 -33.121 -42.180 1.00 45.22 ? 1034 HOH A O 1 HETATM 4725 O O . HOH U 8 . ? -40.824 -27.771 -9.209 1.00 47.67 ? 1035 HOH A O 1 HETATM 4726 O O . HOH U 8 . ? -36.493 -44.680 -29.795 1.00 47.52 ? 1036 HOH A O 1 HETATM 4727 O O . HOH U 8 . ? -38.174 -17.302 -23.831 1.00 47.30 ? 1037 HOH A O 1 HETATM 4728 O O . HOH U 8 . ? -18.128 -31.136 -51.732 1.00 58.83 ? 1038 HOH A O 1 HETATM 4729 O O . HOH U 8 . ? -21.982 -41.404 -21.136 1.00 65.23 ? 1039 HOH A O 1 HETATM 4730 O O . HOH U 8 . ? -0.840 -41.385 -15.450 1.00 50.69 ? 1040 HOH A O 1 HETATM 4731 O O . HOH U 8 . ? -31.896 -19.368 -58.055 1.00 69.41 ? 1041 HOH A O 1 HETATM 4732 O O . HOH U 8 . ? -2.730 -10.094 -23.302 1.00 46.72 ? 1042 HOH A O 1 HETATM 4733 O O . HOH U 8 . ? -16.083 -45.177 -27.080 1.00 57.60 ? 1043 HOH A O 1 # _database_PDB_caveat.id 1 _database_PDB_caveat.text 'VAL A 361 HAS WRONG CHIRALITY AT ATOM CA' # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 GLU 1 1 ? ? ? A . n A 1 2 ASP 2 2 ? ? ? A . n A 1 3 ASP 3 3 3 ASP ASP A . n A 1 4 ILE 4 4 4 ILE ILE A . n A 1 5 ILE 5 5 5 ILE ILE A . n A 1 6 ILE 6 6 6 ILE ILE A . n A 1 7 ALA 7 7 7 ALA ALA A . n A 1 8 THR 8 8 8 THR THR A . n A 1 9 LYS 9 9 9 LYS LYS A . n A 1 10 ASN 10 10 10 ASN ASN A . n A 1 11 GLY 11 11 11 GLY GLY A . n A 1 12 LYS 12 12 12 LYS LYS A . n A 1 13 VAL 13 13 13 VAL VAL A . n A 1 14 ARG 14 14 14 ARG ARG A . n A 1 15 GLY 15 15 15 GLY GLY A . n A 1 16 MET 16 16 16 MET MET A . n A 1 17 GLN 17 17 17 GLN GLN A . n A 1 18 LEU 18 18 18 LEU LEU A . n A 1 19 THR 19 19 19 THR THR A . n A 1 20 VAL 20 20 20 VAL VAL A . n A 1 21 PHE 21 21 21 PHE PHE A . n A 1 22 GLY 22 22 22 GLY GLY A . n A 1 23 GLY 23 23 23 GLY GLY A . n A 1 24 THR 24 24 24 THR THR A . n A 1 25 VAL 25 25 25 VAL VAL A . n A 1 26 THR 26 26 26 THR THR A . n A 1 27 ALA 27 27 27 ALA ALA A . n A 1 28 PHE 28 28 28 PHE PHE A . n A 1 29 LEU 29 29 29 LEU LEU A . n A 1 30 GLY 30 30 30 GLY GLY A . n A 1 31 ILE 31 31 31 ILE ILE A . n A 1 32 PRO 32 32 32 PRO PRO A . n A 1 33 TYR 33 33 33 TYR TYR A . n A 1 34 ALA 34 34 34 ALA ALA A . n A 1 35 GLN 35 35 35 GLN GLN A . n A 1 36 PRO 36 36 36 PRO PRO A . n A 1 37 PRO 37 37 37 PRO PRO A . n A 1 38 LEU 38 38 38 LEU LEU A . n A 1 39 GLY 39 39 39 GLY GLY A . n A 1 40 ARG 40 40 40 ARG ARG A . n A 1 41 LEU 41 41 41 LEU LEU A . n A 1 42 ARG 42 42 42 ARG ARG A . n A 1 43 PHE 43 43 43 PHE PHE A . n A 1 44 LYS 44 44 44 LYS LYS A . n A 1 45 LYS 45 45 45 LYS LYS A . n A 1 46 PRO 46 46 46 PRO PRO A . n A 1 47 GLN 47 47 47 GLN GLN A . n A 1 48 SER 48 48 48 SER SER A . n A 1 49 LEU 49 49 49 LEU LEU A . n A 1 50 THR 50 50 50 THR THR A . n A 1 51 LYS 51 51 51 LYS LYS A . n A 1 52 TRP 52 52 52 TRP TRP A . n A 1 53 THR 53 53 53 THR THR A . n A 1 54 ASP 54 54 54 ASP ASP A . n A 1 55 ILE 55 55 55 ILE ILE A . n A 1 56 TRP 56 56 56 TRP TRP A . n A 1 57 ASN 57 57 57 ASN ASN A . n A 1 58 ALA 58 58 58 ALA ALA A . n A 1 59 THR 59 59 59 THR THR A . n A 1 60 LYS 60 60 60 LYS LYS A . n A 1 61 TYR 61 61 61 TYR TYR A . n A 1 62 ALA 62 62 62 ALA ALA A . n A 1 63 ASN 63 63 63 ASN ASN A . n A 1 64 SER 64 64 64 SER SER A . n A 1 65 CYS 65 65 65 CYS CYS A . n A 1 66 CYS 66 66 66 CYS CYS A . n A 1 67 GLN 67 67 67 GLN GLN A . n A 1 68 ASN 68 68 68 ASN ASN A . n A 1 69 ILE 69 69 69 ILE ILE A . n A 1 70 ASP 70 70 70 ASP ASP A . n A 1 71 GLN 71 71 71 GLN GLN A . n A 1 72 SER 72 72 72 SER SER A . n A 1 73 PHE 73 73 73 PHE PHE A . n A 1 74 PRO 74 74 74 PRO PRO A . n A 1 75 GLY 75 75 75 GLY GLY A . n A 1 76 PHE 76 76 76 PHE PHE A . n A 1 77 HIS 77 77 77 HIS HIS A . n A 1 78 GLY 78 78 78 GLY GLY A . n A 1 79 SER 79 79 79 SER SER A . n A 1 80 GLU 80 80 80 GLU GLU A . n A 1 81 MET 81 81 81 MET MET A . n A 1 82 TRP 82 82 82 TRP TRP A . n A 1 83 ASN 83 83 83 ASN ASN A . n A 1 84 PRO 84 84 84 PRO PRO A . n A 1 85 ASN 85 85 85 ASN ASN A . n A 1 86 THR 86 86 86 THR THR A . n A 1 87 ASP 87 87 87 ASP ASP A . n A 1 88 LEU 88 88 88 LEU LEU A . n A 1 89 SER 89 89 89 SER SER A . n A 1 90 GLU 90 90 90 GLU GLU A . n A 1 91 ASP 91 91 91 ASP ASP A . n A 1 92 CYS 92 92 92 CYS CYS A . n A 1 93 LEU 93 93 93 LEU LEU A . n A 1 94 TYR 94 94 94 TYR TYR A . n A 1 95 LEU 95 95 95 LEU LEU A . n A 1 96 ASN 96 96 96 ASN ASN A . n A 1 97 VAL 97 97 97 VAL VAL A . n A 1 98 TRP 98 98 98 TRP TRP A . n A 1 99 ILE 99 99 99 ILE ILE A . n A 1 100 PRO 100 100 100 PRO PRO A . n A 1 101 ALA 101 101 101 ALA ALA A . n A 1 102 PRO 102 102 102 PRO PRO A . n A 1 103 LYS 103 103 103 LYS LYS A . n A 1 104 PRO 104 104 104 PRO PRO A . n A 1 105 LYS 105 105 105 LYS LYS A . n A 1 106 ASN 106 106 106 ASN ASN A . n A 1 107 ALA 107 107 107 ALA ALA A . n A 1 108 THR 108 108 108 THR THR A . n A 1 109 VAL 109 109 109 VAL VAL A . n A 1 110 LEU 110 110 110 LEU LEU A . n A 1 111 ILE 111 111 111 ILE ILE A . n A 1 112 TRP 112 112 112 TRP TRP A . n A 1 113 ILE 113 113 113 ILE ILE A . n A 1 114 TYR 114 114 114 TYR TYR A . n A 1 115 GLY 115 115 115 GLY GLY A . n A 1 116 GLY 116 116 116 GLY GLY A . n A 1 117 GLY 117 117 117 GLY GLY A . n A 1 118 PHE 118 118 118 PHE PHE A . n A 1 119 GLN 119 119 119 GLN GLN A . n A 1 120 THR 120 120 120 THR THR A . n A 1 121 GLY 121 121 121 GLY GLY A . n A 1 122 THR 122 122 122 THR THR A . n A 1 123 SER 123 123 123 SER SER A . n A 1 124 SER 124 124 124 SER SER A . n A 1 125 LEU 125 125 125 LEU LEU A . n A 1 126 HIS 126 126 126 HIS HIS A . n A 1 127 VAL 127 127 127 VAL VAL A . n A 1 128 TYR 128 128 128 TYR TYR A . n A 1 129 ASP 129 129 129 ASP ASP A . n A 1 130 GLY 130 130 130 GLY GLY A . n A 1 131 LYS 131 131 131 LYS LYS A . n A 1 132 PHE 132 132 132 PHE PHE A . n A 1 133 LEU 133 133 133 LEU LEU A . n A 1 134 ALA 134 134 134 ALA ALA A . n A 1 135 ARG 135 135 135 ARG ARG A . n A 1 136 VAL 136 136 136 VAL VAL A . n A 1 137 GLU 137 137 137 GLU GLU A . n A 1 138 ARG 138 138 138 ARG ARG A . n A 1 139 VAL 139 139 139 VAL VAL A . n A 1 140 ILE 140 140 140 ILE ILE A . n A 1 141 VAL 141 141 141 VAL VAL A . n A 1 142 VAL 142 142 142 VAL VAL A . n A 1 143 SER 143 143 143 SER SER A . n A 1 144 MET 144 144 144 MET MET A . n A 1 145 ASN 145 145 145 ASN ASN A . n A 1 146 TYR 146 146 146 TYR TYR A . n A 1 147 ARG 147 147 147 ARG ARG A . n A 1 148 VAL 148 148 148 VAL VAL A . n A 1 149 GLY 149 149 149 GLY GLY A . n A 1 150 ALA 150 150 150 ALA ALA A . n A 1 151 LEU 151 151 151 LEU LEU A . n A 1 152 GLY 152 152 152 GLY GLY A . n A 1 153 PHE 153 153 153 PHE PHE A . n A 1 154 LEU 154 154 154 LEU LEU A . n A 1 155 ALA 155 155 155 ALA ALA A . n A 1 156 LEU 156 156 156 LEU LEU A . n A 1 157 PRO 157 157 157 PRO PRO A . n A 1 158 GLY 158 158 158 GLY GLY A . n A 1 159 ASN 159 159 159 ASN ASN A . n A 1 160 PRO 160 160 160 PRO PRO A . n A 1 161 GLU 161 161 161 GLU GLU A . n A 1 162 ALA 162 162 162 ALA ALA A . n A 1 163 PRO 163 163 163 PRO PRO A . n A 1 164 GLY 164 164 164 GLY GLY A . n A 1 165 ASN 165 165 165 ASN ASN A . n A 1 166 MET 166 166 166 MET MET A . n A 1 167 GLY 167 167 167 GLY GLY A . n A 1 168 LEU 168 168 168 LEU LEU A . n A 1 169 PHE 169 169 169 PHE PHE A . n A 1 170 ASP 170 170 170 ASP ASP A . n A 1 171 GLN 171 171 171 GLN GLN A . n A 1 172 GLN 172 172 172 GLN GLN A . n A 1 173 LEU 173 173 173 LEU LEU A . n A 1 174 ALA 174 174 174 ALA ALA A . n A 1 175 LEU 175 175 175 LEU LEU A . n A 1 176 GLN 176 176 176 GLN GLN A . n A 1 177 TRP 177 177 177 TRP TRP A . n A 1 178 VAL 178 178 178 VAL VAL A . n A 1 179 GLN 179 179 179 GLN GLN A . n A 1 180 LYS 180 180 180 LYS LYS A . n A 1 181 ASN 181 181 181 ASN ASN A . n A 1 182 ILE 182 182 182 ILE ILE A . n A 1 183 ALA 183 183 183 ALA ALA A . n A 1 184 ALA 184 184 184 ALA ALA A . n A 1 185 PHE 185 185 185 PHE PHE A . n A 1 186 GLY 186 186 186 GLY GLY A . n A 1 187 GLY 187 187 187 GLY GLY A . n A 1 188 ASN 188 188 188 ASN ASN A . n A 1 189 PRO 189 189 189 PRO PRO A . n A 1 190 LYS 190 190 190 LYS LYS A . n A 1 191 SER 191 191 191 SER SER A . n A 1 192 VAL 192 192 192 VAL VAL A . n A 1 193 THR 193 193 193 THR THR A . n A 1 194 LEU 194 194 194 LEU LEU A . n A 1 195 PHE 195 195 195 PHE PHE A . n A 1 196 GLY 196 196 196 GLY GLY A . n A 1 197 GLU 197 197 197 GLU GLU A . n A 1 198 SER 198 198 198 SER SER A . n A 1 199 ALA 199 199 199 ALA ALA A . n A 1 200 GLY 200 200 200 GLY GLY A . n A 1 201 ALA 201 201 201 ALA ALA A . n A 1 202 ALA 202 202 202 ALA ALA A . n A 1 203 SER 203 203 203 SER SER A . n A 1 204 VAL 204 204 204 VAL VAL A . n A 1 205 SER 205 205 205 SER SER A . n A 1 206 LEU 206 206 206 LEU LEU A . n A 1 207 HIS 207 207 207 HIS HIS A . n A 1 208 LEU 208 208 208 LEU LEU A . n A 1 209 LEU 209 209 209 LEU LEU A . n A 1 210 SER 210 210 210 SER SER A . n A 1 211 PRO 211 211 211 PRO PRO A . n A 1 212 GLY 212 212 212 GLY GLY A . n A 1 213 SER 213 213 213 SER SER A . n A 1 214 HIS 214 214 214 HIS HIS A . n A 1 215 SER 215 215 215 SER SER A . n A 1 216 LEU 216 216 216 LEU LEU A . n A 1 217 PHE 217 217 217 PHE PHE A . n A 1 218 THR 218 218 218 THR THR A . n A 1 219 ARG 219 219 219 ARG ARG A . n A 1 220 ALA 220 220 220 ALA ALA A . n A 1 221 ILE 221 221 221 ILE ILE A . n A 1 222 LEU 222 222 222 LEU LEU A . n A 1 223 GLN 223 223 223 GLN GLN A . n A 1 224 SER 224 224 224 SER SER A . n A 1 225 GLY 225 225 225 GLY GLY A . n A 1 226 SER 226 226 226 SER SER A . n A 1 227 PHE 227 227 227 PHE PHE A . n A 1 228 ASN 228 228 228 ASN ASN A . n A 1 229 ALA 229 229 229 ALA ALA A . n A 1 230 PRO 230 230 230 PRO PRO A . n A 1 231 TRP 231 231 231 TRP TRP A . n A 1 232 ALA 232 232 232 ALA ALA A . n A 1 233 VAL 233 233 233 VAL VAL A . n A 1 234 THR 234 234 234 THR THR A . n A 1 235 SER 235 235 235 SER SER A . n A 1 236 LEU 236 236 236 LEU LEU A . n A 1 237 TYR 237 237 237 TYR TYR A . n A 1 238 GLU 238 238 238 GLU GLU A . n A 1 239 ALA 239 239 239 ALA ALA A . n A 1 240 ARG 240 240 240 ARG ARG A . n A 1 241 ASN 241 241 241 ASN ASN A . n A 1 242 ARG 242 242 242 ARG ARG A . n A 1 243 THR 243 243 243 THR THR A . n A 1 244 LEU 244 244 244 LEU LEU A . n A 1 245 ASN 245 245 245 ASN ASN A . n A 1 246 LEU 246 246 246 LEU LEU A . n A 1 247 ALA 247 247 247 ALA ALA A . n A 1 248 LYS 248 248 248 LYS LYS A . n A 1 249 LEU 249 249 249 LEU LEU A . n A 1 250 THR 250 250 250 THR THR A . n A 1 251 GLY 251 251 251 GLY GLY A . n A 1 252 CYS 252 252 252 CYS CYS A . n A 1 253 SER 253 253 253 SER SER A . n A 1 254 ARG 254 254 254 ARG ARG A . n A 1 255 GLU 255 255 255 GLU GLU A . n A 1 256 ASN 256 256 256 ASN ASN A . n A 1 257 GLU 257 257 257 GLU GLU A . n A 1 258 THR 258 258 258 THR THR A . n A 1 259 GLU 259 259 259 GLU GLU A . n A 1 260 ILE 260 260 260 ILE ILE A . n A 1 261 ILE 261 261 261 ILE ILE A . n A 1 262 LYS 262 262 262 LYS LYS A . n A 1 263 CYS 263 263 263 CYS CYS A . n A 1 264 LEU 264 264 264 LEU LEU A . n A 1 265 ARG 265 265 265 ARG ARG A . n A 1 266 ASN 266 266 266 ASN ASN A . n A 1 267 LYS 267 267 267 LYS LYS A . n A 1 268 ASP 268 268 268 ASP ASP A . n A 1 269 PRO 269 269 269 PRO PRO A . n A 1 270 GLN 270 270 270 GLN GLN A . n A 1 271 GLU 271 271 271 GLU GLU A . n A 1 272 ILE 272 272 272 ILE ILE A . n A 1 273 LEU 273 273 273 LEU LEU A . n A 1 274 LEU 274 274 274 LEU LEU A . n A 1 275 ASN 275 275 275 ASN ASN A . n A 1 276 GLU 276 276 276 GLU GLU A . n A 1 277 ALA 277 277 277 ALA ALA A . n A 1 278 PHE 278 278 278 PHE PHE A . n A 1 279 VAL 279 279 279 VAL VAL A . n A 1 280 VAL 280 280 280 VAL VAL A . n A 1 281 PRO 281 281 281 PRO PRO A . n A 1 282 TYR 282 282 282 TYR TYR A . n A 1 283 GLY 283 283 283 GLY GLY A . n A 1 284 THR 284 284 284 THR THR A . n A 1 285 PRO 285 285 285 PRO PRO A . n A 1 286 LEU 286 286 286 LEU LEU A . n A 1 287 SER 287 287 287 SER SER A . n A 1 288 VAL 288 288 288 VAL VAL A . n A 1 289 ASN 289 289 289 ASN ASN A . n A 1 290 PHE 290 290 290 PHE PHE A . n A 1 291 GLY 291 291 291 GLY GLY A . n A 1 292 PRO 292 292 292 PRO PRO A . n A 1 293 THR 293 293 293 THR THR A . n A 1 294 VAL 294 294 294 VAL VAL A . n A 1 295 ASP 295 295 295 ASP ASP A . n A 1 296 GLY 296 296 296 GLY GLY A . n A 1 297 ASP 297 297 297 ASP ASP A . n A 1 298 PHE 298 298 298 PHE PHE A . n A 1 299 LEU 299 299 299 LEU LEU A . n A 1 300 THR 300 300 300 THR THR A . n A 1 301 ASP 301 301 301 ASP ASP A . n A 1 302 MET 302 302 302 MET MET A . n A 1 303 PRO 303 303 303 PRO PRO A . n A 1 304 ASP 304 304 304 ASP ASP A . n A 1 305 ILE 305 305 305 ILE ILE A . n A 1 306 LEU 306 306 306 LEU LEU A . n A 1 307 LEU 307 307 307 LEU LEU A . n A 1 308 GLU 308 308 308 GLU GLU A . n A 1 309 LEU 309 309 309 LEU LEU A . n A 1 310 GLY 310 310 310 GLY GLY A . n A 1 311 GLN 311 311 311 GLN GLN A . n A 1 312 PHE 312 312 312 PHE PHE A . n A 1 313 LYS 313 313 313 LYS LYS A . n A 1 314 LYS 314 314 314 LYS LYS A . n A 1 315 THR 315 315 315 THR THR A . n A 1 316 GLN 316 316 316 GLN GLN A . n A 1 317 ILE 317 317 317 ILE ILE A . n A 1 318 LEU 318 318 318 LEU LEU A . n A 1 319 VAL 319 319 319 VAL VAL A . n A 1 320 GLY 320 320 320 GLY GLY A . n A 1 321 VAL 321 321 321 VAL VAL A . n A 1 322 ASN 322 322 322 ASN ASN A . n A 1 323 LYS 323 323 323 LYS LYS A . n A 1 324 ASP 324 324 324 ASP ASP A . n A 1 325 GLU 325 325 325 GLU GLU A . n A 1 326 GLY 326 326 326 GLY GLY A . n A 1 327 THR 327 327 327 THR THR A . n A 1 328 ALA 328 328 328 ALA ALA A . n A 1 329 PHE 329 329 329 PHE PHE A . n A 1 330 LEU 330 330 330 LEU LEU A . n A 1 331 VAL 331 331 331 VAL VAL A . n A 1 332 TYR 332 332 332 TYR TYR A . n A 1 333 GLY 333 333 333 GLY GLY A . n A 1 334 ALA 334 334 334 ALA ALA A . n A 1 335 PRO 335 335 335 PRO PRO A . n A 1 336 GLY 336 336 336 GLY GLY A . n A 1 337 PHE 337 337 337 PHE PHE A . n A 1 338 SER 338 338 338 SER SER A . n A 1 339 LYS 339 339 339 LYS LYS A . n A 1 340 ASP 340 340 340 ASP ASP A . n A 1 341 ASN 341 341 341 ASN ASN A . n A 1 342 ASN 342 342 342 ASN ASN A . n A 1 343 SER 343 343 343 SER SER A . n A 1 344 ILE 344 344 344 ILE ILE A . n A 1 345 ILE 345 345 345 ILE ILE A . n A 1 346 THR 346 346 346 THR THR A . n A 1 347 ARG 347 347 347 ARG ARG A . n A 1 348 LYS 348 348 348 LYS LYS A . n A 1 349 GLU 349 349 349 GLU GLU A . n A 1 350 PHE 350 350 350 PHE PHE A . n A 1 351 GLN 351 351 351 GLN GLN A . n A 1 352 GLU 352 352 352 GLU GLU A . n A 1 353 GLY 353 353 353 GLY GLY A . n A 1 354 LEU 354 354 354 LEU LEU A . n A 1 355 LYS 355 355 355 LYS LYS A . n A 1 356 ILE 356 356 356 ILE ILE A . n A 1 357 PHE 357 357 357 PHE PHE A . n A 1 358 PHE 358 358 358 PHE PHE A . n A 1 359 PRO 359 359 359 PRO PRO A . n A 1 360 GLY 360 360 360 GLY GLY A . n A 1 361 VAL 361 361 361 VAL VAL A . n A 1 362 SER 362 362 362 SER SER A . n A 1 363 GLU 363 363 363 GLU GLU A . n A 1 364 PHE 364 364 364 PHE PHE A . n A 1 365 GLY 365 365 365 GLY GLY A . n A 1 366 LYS 366 366 366 LYS LYS A . n A 1 367 GLU 367 367 367 GLU GLU A . n A 1 368 SER 368 368 368 SER SER A . n A 1 369 ILE 369 369 369 ILE ILE A . n A 1 370 LEU 370 370 370 LEU LEU A . n A 1 371 PHE 371 371 371 PHE PHE A . n A 1 372 HIS 372 372 372 HIS HIS A . n A 1 373 TYR 373 373 373 TYR TYR A . n A 1 374 THR 374 374 374 THR THR A . n A 1 375 ASP 375 375 375 ASP ASP A . n A 1 376 TRP 376 376 376 TRP TRP A . n A 1 377 VAL 377 377 377 VAL VAL A . n A 1 378 ASP 378 378 378 ASP ASP A . n A 1 379 ASP 379 379 379 ASP ASP A . n A 1 380 GLN 380 380 380 GLN GLN A . n A 1 381 ARG 381 381 381 ARG ARG A . n A 1 382 PRO 382 382 382 PRO PRO A . n A 1 383 GLU 383 383 383 GLU GLU A . n A 1 384 ASN 384 384 384 ASN ASN A . n A 1 385 TYR 385 385 385 TYR TYR A . n A 1 386 ARG 386 386 386 ARG ARG A . n A 1 387 GLU 387 387 387 GLU GLU A . n A 1 388 ALA 388 388 388 ALA ALA A . n A 1 389 LEU 389 389 389 LEU LEU A . n A 1 390 GLY 390 390 390 GLY GLY A . n A 1 391 ASP 391 391 391 ASP ASP A . n A 1 392 VAL 392 392 392 VAL VAL A . n A 1 393 VAL 393 393 393 VAL VAL A . n A 1 394 GLY 394 394 394 GLY GLY A . n A 1 395 ASP 395 395 395 ASP ASP A . n A 1 396 TYR 396 396 396 TYR TYR A . n A 1 397 ASN 397 397 397 ASN ASN A . n A 1 398 PHE 398 398 398 PHE PHE A . n A 1 399 ILE 399 399 399 ILE ILE A . n A 1 400 CYS 400 400 400 CYS CYS A . n A 1 401 PRO 401 401 401 PRO PRO A . n A 1 402 ALA 402 402 402 ALA ALA A . n A 1 403 LEU 403 403 403 LEU LEU A . n A 1 404 GLU 404 404 404 GLU GLU A . n A 1 405 PHE 405 405 405 PHE PHE A . n A 1 406 THR 406 406 406 THR THR A . n A 1 407 LYS 407 407 407 LYS LYS A . n A 1 408 LYS 408 408 408 LYS LYS A . n A 1 409 PHE 409 409 409 PHE PHE A . n A 1 410 SER 410 410 410 SER SER A . n A 1 411 GLU 411 411 411 GLU GLU A . n A 1 412 TRP 412 412 412 TRP TRP A . n A 1 413 GLY 413 413 413 GLY GLY A . n A 1 414 ASN 414 414 414 ASN ASN A . n A 1 415 ASN 415 415 415 ASN ASN A . n A 1 416 ALA 416 416 416 ALA ALA A . n A 1 417 PHE 417 417 417 PHE PHE A . n A 1 418 PHE 418 418 418 PHE PHE A . n A 1 419 TYR 419 419 419 TYR TYR A . n A 1 420 TYR 420 420 420 TYR TYR A . n A 1 421 PHE 421 421 421 PHE PHE A . n A 1 422 GLU 422 422 422 GLU GLU A . n A 1 423 HIS 423 423 423 HIS HIS A . n A 1 424 ARG 424 424 424 ARG ARG A . n A 1 425 SER 425 425 425 SER SER A . n A 1 426 SER 426 426 426 SER SER A . n A 1 427 LYS 427 427 427 LYS LYS A . n A 1 428 LEU 428 428 428 LEU LEU A . n A 1 429 PRO 429 429 429 PRO PRO A . n A 1 430 TRP 430 430 430 TRP TRP A . n A 1 431 PRO 431 431 431 PRO PRO A . n A 1 432 GLU 432 432 432 GLU GLU A . n A 1 433 TRP 433 433 433 TRP TRP A . n A 1 434 MET 434 434 434 MET MET A . n A 1 435 GLY 435 435 435 GLY GLY A . n A 1 436 VAL 436 436 436 VAL VAL A . n A 1 437 MET 437 437 437 MET MET A . n A 1 438 HIS 438 438 438 HIS HIS A . n A 1 439 GLY 439 439 439 GLY GLY A . n A 1 440 TYR 440 440 440 TYR TYR A . n A 1 441 GLU 441 441 441 GLU GLU A . n A 1 442 ILE 442 442 442 ILE ILE A . n A 1 443 GLU 443 443 443 GLU GLU A . n A 1 444 PHE 444 444 444 PHE PHE A . n A 1 445 VAL 445 445 445 VAL VAL A . n A 1 446 PHE 446 446 446 PHE PHE A . n A 1 447 GLY 447 447 447 GLY GLY A . n A 1 448 LEU 448 448 448 LEU LEU A . n A 1 449 PRO 449 449 449 PRO PRO A . n A 1 450 LEU 450 450 450 LEU LEU A . n A 1 451 GLU 451 451 451 GLU GLU A . n A 1 452 ARG 452 452 452 ARG ARG A . n A 1 453 ARG 453 453 453 ARG ARG A . n A 1 454 ASP 454 454 454 ASP ASP A . n A 1 455 GLN 455 455 455 GLN GLN A . n A 1 456 TYR 456 456 456 TYR TYR A . n A 1 457 THR 457 457 457 THR THR A . n A 1 458 LYS 458 458 458 LYS LYS A . n A 1 459 ALA 459 459 459 ALA ALA A . n A 1 460 GLU 460 460 460 GLU GLU A . n A 1 461 GLU 461 461 461 GLU GLU A . n A 1 462 ILE 462 462 462 ILE ILE A . n A 1 463 LEU 463 463 463 LEU LEU A . n A 1 464 SER 464 464 464 SER SER A . n A 1 465 ARG 465 465 465 ARG ARG A . n A 1 466 SER 466 466 466 SER SER A . n A 1 467 ILE 467 467 467 ILE ILE A . n A 1 468 VAL 468 468 468 VAL VAL A . n A 1 469 LYS 469 469 469 LYS LYS A . n A 1 470 ARG 470 470 470 ARG ARG A . n A 1 471 TRP 471 471 471 TRP TRP A . n A 1 472 ALA 472 472 472 ALA ALA A . n A 1 473 ASN 473 473 473 ASN ASN A . n A 1 474 PHE 474 474 474 PHE PHE A . n A 1 475 ALA 475 475 475 ALA ALA A . n A 1 476 LYS 476 476 476 LYS LYS A . n A 1 477 TYR 477 477 477 TYR TYR A . n A 1 478 GLY 478 478 478 GLY GLY A . n A 1 479 ASN 479 479 479 ASN ASN A . n A 1 480 PRO 480 480 480 PRO PRO A . n A 1 481 GLN 481 481 481 GLN GLN A . n A 1 482 GLU 482 482 482 GLU GLU A . n A 1 483 THR 483 483 483 THR THR A . n A 1 484 GLN 484 484 484 GLN GLN A . n A 1 485 ASN 485 485 485 ASN ASN A . n A 1 486 ASN 486 486 486 ASN ASN A . n A 1 487 SER 487 487 487 SER SER A . n A 1 488 THR 488 488 488 THR THR A . n A 1 489 SER 489 489 489 SER SER A . n A 1 490 TRP 490 490 490 TRP TRP A . n A 1 491 PRO 491 491 491 PRO PRO A . n A 1 492 VAL 492 492 492 VAL VAL A . n A 1 493 PHE 493 493 493 PHE PHE A . n A 1 494 LYS 494 494 494 LYS LYS A . n A 1 495 SER 495 495 495 SER SER A . n A 1 496 THR 496 496 496 THR THR A . n A 1 497 GLU 497 497 497 GLU GLU A . n A 1 498 GLN 498 498 498 GLN GLN A . n A 1 499 LYS 499 499 499 LYS LYS A . n A 1 500 TYR 500 500 500 TYR TYR A . n A 1 501 LEU 501 501 501 LEU LEU A . n A 1 502 THR 502 502 502 THR THR A . n A 1 503 LEU 503 503 503 LEU LEU A . n A 1 504 ASN 504 504 504 ASN ASN A . n A 1 505 THR 505 505 505 THR THR A . n A 1 506 GLU 506 506 506 GLU GLU A . n A 1 507 SER 507 507 507 SER SER A . n A 1 508 THR 508 508 508 THR THR A . n A 1 509 ARG 509 509 509 ARG ARG A . n A 1 510 ILE 510 510 510 ILE ILE A . n A 1 511 MET 511 511 511 MET MET A . n A 1 512 THR 512 512 512 THR THR A . n A 1 513 LYS 513 513 513 LYS LYS A . n A 1 514 LEU 514 514 514 LEU LEU A . n A 1 515 ARG 515 515 515 ARG ARG A . n A 1 516 ALA 516 516 516 ALA ALA A . n A 1 517 GLN 517 517 517 GLN GLN A . n A 1 518 GLN 518 518 518 GLN GLN A . n A 1 519 CYS 519 519 519 CYS CYS A . n A 1 520 ARG 520 520 520 ARG ARG A . n A 1 521 PHE 521 521 521 PHE PHE A . n A 1 522 TRP 522 522 522 TRP TRP A . n A 1 523 THR 523 523 523 THR THR A . n A 1 524 SER 524 524 524 SER SER A . n A 1 525 PHE 525 525 525 PHE PHE A . n A 1 526 PHE 526 526 526 PHE PHE A . n A 1 527 PRO 527 527 527 PRO PRO A . n A 1 528 LYS 528 528 528 LYS LYS A . n A 1 529 VAL 529 529 529 VAL VAL A . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code B 2 TC3 1 601 1530 TC3 TC3 A . C 3 NA 1 602 1531 NA NA A . D 4 SO4 1 603 1532 SO4 SO4 A . E 5 CL 1 604 1533 CL CL A . F 5 CL 1 605 1534 CL CL A . G 5 CL 1 606 1535 CL CL A . H 4 SO4 1 607 1536 SO4 SO4 A . I 5 CL 1 608 1537 CL CL A . J 6 NAG 1 609 1538 NAG NAG A . K 6 NAG 2 610 1539 NAG NAG A . L 7 FUL 3 611 1540 FUL FUL A . M 6 NAG 1 612 1541 NAG NAG A . N 7 FUL 2 613 1542 FUL FUL A . O 6 NAG 1 614 1543 NAG NAG A . P 6 NAG 1 615 1544 NAG NAG A . Q 6 NAG 1 616 1545 NAG NAG A . R 6 NAG 1 617 1546 NAG NAG A . S 6 NAG 2 618 1547 NAG NAG A . T 7 FUL 3 619 1548 FUL FUL A . U 8 HOH 1 701 2092 HOH HOH A . U 8 HOH 2 702 2328 HOH HOH A . U 8 HOH 3 703 2294 HOH HOH A . U 8 HOH 4 704 2305 HOH HOH A . U 8 HOH 5 705 2014 HOH HOH A . U 8 HOH 6 706 2044 HOH HOH A . U 8 HOH 7 707 2253 HOH HOH A . U 8 HOH 8 708 2244 HOH HOH A . U 8 HOH 9 709 2292 HOH HOH A . U 8 HOH 10 710 2167 HOH HOH A . U 8 HOH 11 711 2077 HOH HOH A . U 8 HOH 12 712 2045 HOH HOH A . U 8 HOH 13 713 2160 HOH HOH A . U 8 HOH 14 714 2202 HOH HOH A . U 8 HOH 15 715 2066 HOH HOH A . U 8 HOH 16 716 2154 HOH HOH A . U 8 HOH 17 717 2201 HOH HOH A . U 8 HOH 18 718 2267 HOH HOH A . U 8 HOH 19 719 2022 HOH HOH A . U 8 HOH 20 720 2030 HOH HOH A . U 8 HOH 21 721 2279 HOH HOH A . U 8 HOH 22 722 2297 HOH HOH A . U 8 HOH 23 723 2003 HOH HOH A . U 8 HOH 24 724 2304 HOH HOH A . U 8 HOH 25 725 2068 HOH HOH A . U 8 HOH 26 726 2333 HOH HOH A . U 8 HOH 27 727 2145 HOH HOH A . U 8 HOH 28 728 2177 HOH HOH A . U 8 HOH 29 729 2251 HOH HOH A . U 8 HOH 30 730 2261 HOH HOH A . U 8 HOH 31 731 2109 HOH HOH A . U 8 HOH 32 732 2083 HOH HOH A . U 8 HOH 33 733 2105 HOH HOH A . U 8 HOH 34 734 2061 HOH HOH A . U 8 HOH 35 735 2341 HOH HOH A . U 8 HOH 36 736 2102 HOH HOH A . U 8 HOH 37 737 2032 HOH HOH A . U 8 HOH 38 738 2301 HOH HOH A . U 8 HOH 39 739 2216 HOH HOH A . U 8 HOH 40 740 2291 HOH HOH A . U 8 HOH 41 741 2133 HOH HOH A . U 8 HOH 42 742 2170 HOH HOH A . U 8 HOH 43 743 2147 HOH HOH A . U 8 HOH 44 744 2296 HOH HOH A . U 8 HOH 45 745 2175 HOH HOH A . U 8 HOH 46 746 2262 HOH HOH A . U 8 HOH 47 747 2108 HOH HOH A . U 8 HOH 48 748 2094 HOH HOH A . U 8 HOH 49 749 2172 HOH HOH A . U 8 HOH 50 750 2180 HOH HOH A . U 8 HOH 51 751 2074 HOH HOH A . U 8 HOH 52 752 2275 HOH HOH A . U 8 HOH 53 753 2237 HOH HOH A . U 8 HOH 54 754 2213 HOH HOH A . U 8 HOH 55 755 2107 HOH HOH A . U 8 HOH 56 756 2269 HOH HOH A . U 8 HOH 57 757 2223 HOH HOH A . U 8 HOH 58 758 2240 HOH HOH A . U 8 HOH 59 759 2273 HOH HOH A . U 8 HOH 60 760 2087 HOH HOH A . U 8 HOH 61 761 2093 HOH HOH A . U 8 HOH 62 762 2073 HOH HOH A . U 8 HOH 63 763 2069 HOH HOH A . U 8 HOH 64 764 2230 HOH HOH A . U 8 HOH 65 765 2064 HOH HOH A . U 8 HOH 66 766 2111 HOH HOH A . U 8 HOH 67 767 2313 HOH HOH A . U 8 HOH 68 768 2283 HOH HOH A . U 8 HOH 69 769 2315 HOH HOH A . U 8 HOH 70 770 2182 HOH HOH A . U 8 HOH 71 771 2132 HOH HOH A . U 8 HOH 72 772 2018 HOH HOH A . U 8 HOH 73 773 2178 HOH HOH A . U 8 HOH 74 774 2248 HOH HOH A . U 8 HOH 75 775 2127 HOH HOH A . U 8 HOH 76 776 2214 HOH HOH A . U 8 HOH 77 777 2124 HOH HOH A . U 8 HOH 78 778 2289 HOH HOH A . U 8 HOH 79 779 2117 HOH HOH A . U 8 HOH 80 780 2210 HOH HOH A . U 8 HOH 81 781 2072 HOH HOH A . U 8 HOH 82 782 2274 HOH HOH A . U 8 HOH 83 783 2088 HOH HOH A . U 8 HOH 84 784 2099 HOH HOH A . U 8 HOH 85 785 2307 HOH HOH A . U 8 HOH 86 786 2129 HOH HOH A . U 8 HOH 87 787 2135 HOH HOH A . U 8 HOH 88 788 2322 HOH HOH A . U 8 HOH 89 789 2298 HOH HOH A . U 8 HOH 90 790 2165 HOH HOH A . U 8 HOH 91 791 2096 HOH HOH A . U 8 HOH 92 792 2162 HOH HOH A . U 8 HOH 93 793 2021 HOH HOH A . U 8 HOH 94 794 2194 HOH HOH A . U 8 HOH 95 795 2184 HOH HOH A . U 8 HOH 96 796 2185 HOH HOH A . U 8 HOH 97 797 2247 HOH HOH A . U 8 HOH 98 798 2260 HOH HOH A . U 8 HOH 99 799 2115 HOH HOH A . U 8 HOH 100 800 2084 HOH HOH A . U 8 HOH 101 801 2164 HOH HOH A . U 8 HOH 102 802 2268 HOH HOH A . U 8 HOH 103 803 2054 HOH HOH A . U 8 HOH 104 804 2266 HOH HOH A . U 8 HOH 105 805 2065 HOH HOH A . U 8 HOH 106 806 2153 HOH HOH A . U 8 HOH 107 807 2100 HOH HOH A . U 8 HOH 108 808 2293 HOH HOH A . U 8 HOH 109 809 2232 HOH HOH A . U 8 HOH 110 810 2282 HOH HOH A . U 8 HOH 111 811 2110 HOH HOH A . U 8 HOH 112 812 2290 HOH HOH A . U 8 HOH 113 813 2060 HOH HOH A . U 8 HOH 114 814 2137 HOH HOH A . U 8 HOH 115 815 2026 HOH HOH A . U 8 HOH 116 816 2181 HOH HOH A . U 8 HOH 117 817 2161 HOH HOH A . U 8 HOH 118 818 2001 HOH HOH A . U 8 HOH 119 819 2281 HOH HOH A . U 8 HOH 120 820 2120 HOH HOH A . U 8 HOH 121 821 2079 HOH HOH A . U 8 HOH 122 822 2208 HOH HOH A . U 8 HOH 123 823 2336 HOH HOH A . U 8 HOH 124 824 2276 HOH HOH A . U 8 HOH 125 825 2324 HOH HOH A . U 8 HOH 126 826 2196 HOH HOH A . U 8 HOH 127 827 2193 HOH HOH A . U 8 HOH 128 828 2306 HOH HOH A . U 8 HOH 129 829 2280 HOH HOH A . U 8 HOH 130 830 2303 HOH HOH A . U 8 HOH 131 831 2095 HOH HOH A . U 8 HOH 132 832 2252 HOH HOH A . U 8 HOH 133 833 2142 HOH HOH A . U 8 HOH 134 834 2287 HOH HOH A . U 8 HOH 135 835 2024 HOH HOH A . U 8 HOH 136 836 2070 HOH HOH A . U 8 HOH 137 837 2259 HOH HOH A . U 8 HOH 138 838 2218 HOH HOH A . U 8 HOH 139 839 2098 HOH HOH A . U 8 HOH 140 840 2090 HOH HOH A . U 8 HOH 141 841 2151 HOH HOH A . U 8 HOH 142 842 2171 HOH HOH A . U 8 HOH 143 843 2191 HOH HOH A . U 8 HOH 144 844 2116 HOH HOH A . U 8 HOH 145 845 2134 HOH HOH A . U 8 HOH 146 846 2231 HOH HOH A . U 8 HOH 147 847 2317 HOH HOH A . U 8 HOH 148 848 2270 HOH HOH A . U 8 HOH 149 849 2299 HOH HOH A . U 8 HOH 150 850 2199 HOH HOH A . U 8 HOH 151 851 2319 HOH HOH A . U 8 HOH 152 852 2278 HOH HOH A . U 8 HOH 153 853 2126 HOH HOH A . U 8 HOH 154 854 2091 HOH HOH A . U 8 HOH 155 855 2235 HOH HOH A . U 8 HOH 156 856 2246 HOH HOH A . U 8 HOH 157 857 2076 HOH HOH A . U 8 HOH 158 858 2310 HOH HOH A . U 8 HOH 159 859 2010 HOH HOH A . U 8 HOH 160 860 2176 HOH HOH A . U 8 HOH 161 861 2186 HOH HOH A . U 8 HOH 162 862 2078 HOH HOH A . U 8 HOH 163 863 2234 HOH HOH A . U 8 HOH 164 864 2250 HOH HOH A . U 8 HOH 165 865 2148 HOH HOH A . U 8 HOH 166 866 2284 HOH HOH A . U 8 HOH 167 867 2224 HOH HOH A . U 8 HOH 168 868 2215 HOH HOH A . U 8 HOH 169 869 2035 HOH HOH A . U 8 HOH 170 870 2156 HOH HOH A . U 8 HOH 171 871 2239 HOH HOH A . U 8 HOH 172 872 2118 HOH HOH A . U 8 HOH 173 873 2158 HOH HOH A . U 8 HOH 174 874 2053 HOH HOH A . U 8 HOH 175 875 2190 HOH HOH A . U 8 HOH 176 876 2314 HOH HOH A . U 8 HOH 177 877 2101 HOH HOH A . U 8 HOH 178 878 2189 HOH HOH A . U 8 HOH 179 879 2203 HOH HOH A . U 8 HOH 180 880 2343 HOH HOH A . U 8 HOH 181 881 2149 HOH HOH A . U 8 HOH 182 882 2082 HOH HOH A . U 8 HOH 183 883 2263 HOH HOH A . U 8 HOH 184 884 2028 HOH HOH A . U 8 HOH 185 885 2173 HOH HOH A . U 8 HOH 186 886 2200 HOH HOH A . U 8 HOH 187 887 2163 HOH HOH A . U 8 HOH 188 888 2058 HOH HOH A . U 8 HOH 189 889 2192 HOH HOH A . U 8 HOH 190 890 2339 HOH HOH A . U 8 HOH 191 891 2228 HOH HOH A . U 8 HOH 192 892 2123 HOH HOH A . U 8 HOH 193 893 2169 HOH HOH A . U 8 HOH 194 894 2057 HOH HOH A . U 8 HOH 195 895 2146 HOH HOH A . U 8 HOH 196 896 2051 HOH HOH A . U 8 HOH 197 897 2302 HOH HOH A . U 8 HOH 198 898 2264 HOH HOH A . U 8 HOH 199 899 2217 HOH HOH A . U 8 HOH 200 900 2285 HOH HOH A . U 8 HOH 201 901 2340 HOH HOH A . U 8 HOH 202 902 2308 HOH HOH A . U 8 HOH 203 903 2238 HOH HOH A . U 8 HOH 204 904 2257 HOH HOH A . U 8 HOH 205 905 2128 HOH HOH A . U 8 HOH 206 906 2312 HOH HOH A . U 8 HOH 207 907 2207 HOH HOH A . U 8 HOH 208 908 2075 HOH HOH A . U 8 HOH 209 909 2323 HOH HOH A . U 8 HOH 210 910 2138 HOH HOH A . U 8 HOH 211 911 2331 HOH HOH A . U 8 HOH 212 912 2325 HOH HOH A . U 8 HOH 213 913 2197 HOH HOH A . U 8 HOH 214 914 2063 HOH HOH A . U 8 HOH 215 915 2225 HOH HOH A . U 8 HOH 216 916 2157 HOH HOH A . U 8 HOH 217 917 2271 HOH HOH A . U 8 HOH 218 918 2233 HOH HOH A . U 8 HOH 219 919 2255 HOH HOH A . U 8 HOH 220 920 2081 HOH HOH A . U 8 HOH 221 921 2236 HOH HOH A . U 8 HOH 222 922 2059 HOH HOH A . U 8 HOH 223 923 2316 HOH HOH A . U 8 HOH 224 924 2187 HOH HOH A . U 8 HOH 225 925 2327 HOH HOH A . U 8 HOH 226 926 2227 HOH HOH A . U 8 HOH 227 927 2209 HOH HOH A . U 8 HOH 228 928 2007 HOH HOH A . U 8 HOH 229 929 2106 HOH HOH A . U 8 HOH 230 930 2188 HOH HOH A . U 8 HOH 231 931 2256 HOH HOH A . U 8 HOH 232 932 2055 HOH HOH A . U 8 HOH 233 933 2048 HOH HOH A . U 8 HOH 234 934 2195 HOH HOH A . U 8 HOH 235 935 2249 HOH HOH A . U 8 HOH 236 936 2174 HOH HOH A . U 8 HOH 237 937 2295 HOH HOH A . U 8 HOH 238 938 2050 HOH HOH A . U 8 HOH 239 939 2040 HOH HOH A . U 8 HOH 240 940 2041 HOH HOH A . U 8 HOH 241 941 2067 HOH HOH A . U 8 HOH 242 942 2309 HOH HOH A . U 8 HOH 243 943 2243 HOH HOH A . U 8 HOH 244 944 2222 HOH HOH A . U 8 HOH 245 945 2337 HOH HOH A . U 8 HOH 246 946 2226 HOH HOH A . U 8 HOH 247 947 2043 HOH HOH A . U 8 HOH 248 948 2212 HOH HOH A . U 8 HOH 249 949 2221 HOH HOH A . U 8 HOH 250 950 2204 HOH HOH A . U 8 HOH 251 951 2326 HOH HOH A . U 8 HOH 252 952 2016 HOH HOH A . U 8 HOH 253 953 2229 HOH HOH A . U 8 HOH 254 954 2062 HOH HOH A . U 8 HOH 255 955 2140 HOH HOH A . U 8 HOH 256 956 2245 HOH HOH A . U 8 HOH 257 957 2036 HOH HOH A . U 8 HOH 258 958 2052 HOH HOH A . U 8 HOH 259 959 2179 HOH HOH A . U 8 HOH 260 960 2047 HOH HOH A . U 8 HOH 261 961 2071 HOH HOH A . U 8 HOH 262 962 2011 HOH HOH A . U 8 HOH 263 963 2113 HOH HOH A . U 8 HOH 264 964 2038 HOH HOH A . U 8 HOH 265 965 2254 HOH HOH A . U 8 HOH 266 966 2039 HOH HOH A . U 8 HOH 267 967 2086 HOH HOH A . U 8 HOH 268 968 2332 HOH HOH A . U 8 HOH 269 969 2085 HOH HOH A . U 8 HOH 270 970 2321 HOH HOH A . U 8 HOH 271 971 2166 HOH HOH A . U 8 HOH 272 972 2183 HOH HOH A . U 8 HOH 273 973 2334 HOH HOH A . U 8 HOH 274 974 2211 HOH HOH A . U 8 HOH 275 975 2089 HOH HOH A . U 8 HOH 276 976 2330 HOH HOH A . U 8 HOH 277 977 2320 HOH HOH A . U 8 HOH 278 978 2168 HOH HOH A . U 8 HOH 279 979 2329 HOH HOH A . U 8 HOH 280 980 2206 HOH HOH A . U 8 HOH 281 981 2049 HOH HOH A . U 8 HOH 282 982 2286 HOH HOH A . U 8 HOH 283 983 2258 HOH HOH A . U 8 HOH 284 984 2300 HOH HOH A . U 8 HOH 285 985 2046 HOH HOH A . U 8 HOH 286 986 2338 HOH HOH A . U 8 HOH 287 987 2288 HOH HOH A . U 8 HOH 288 988 2311 HOH HOH A . U 8 HOH 289 989 2159 HOH HOH A . U 8 HOH 290 990 2017 HOH HOH A . U 8 HOH 291 991 2152 HOH HOH A . U 8 HOH 292 992 2335 HOH HOH A . U 8 HOH 293 993 2012 HOH HOH A . U 8 HOH 294 994 2033 HOH HOH A . U 8 HOH 295 995 2318 HOH HOH A . U 8 HOH 296 996 2031 HOH HOH A . U 8 HOH 297 997 2277 HOH HOH A . U 8 HOH 298 998 2219 HOH HOH A . U 8 HOH 299 999 2220 HOH HOH A . U 8 HOH 300 1000 2136 HOH HOH A . U 8 HOH 301 1001 2114 HOH HOH A . U 8 HOH 302 1002 2080 HOH HOH A . U 8 HOH 303 1003 2097 HOH HOH A . U 8 HOH 304 1004 2029 HOH HOH A . U 8 HOH 305 1005 2112 HOH HOH A . U 8 HOH 306 1006 2342 HOH HOH A . U 8 HOH 307 1007 2241 HOH HOH A . U 8 HOH 308 1008 2125 HOH HOH A . U 8 HOH 309 1009 2009 HOH HOH A . U 8 HOH 310 1010 2104 HOH HOH A . U 8 HOH 311 1011 2265 HOH HOH A . U 8 HOH 312 1012 2155 HOH HOH A . U 8 HOH 313 1013 2002 HOH HOH A . U 8 HOH 314 1014 2141 HOH HOH A . U 8 HOH 315 1015 2027 HOH HOH A . U 8 HOH 316 1016 2005 HOH HOH A . U 8 HOH 317 1017 2131 HOH HOH A . U 8 HOH 318 1018 2139 HOH HOH A . U 8 HOH 319 1019 2122 HOH HOH A . U 8 HOH 320 1020 2037 HOH HOH A . U 8 HOH 321 1021 2143 HOH HOH A . U 8 HOH 322 1022 2008 HOH HOH A . U 8 HOH 323 1023 2205 HOH HOH A . U 8 HOH 324 1024 2198 HOH HOH A . U 8 HOH 325 1025 2042 HOH HOH A . U 8 HOH 326 1026 2150 HOH HOH A . U 8 HOH 327 1027 2019 HOH HOH A . U 8 HOH 328 1028 2242 HOH HOH A . U 8 HOH 329 1029 2025 HOH HOH A . U 8 HOH 330 1030 2015 HOH HOH A . U 8 HOH 331 1031 2121 HOH HOH A . U 8 HOH 332 1032 2056 HOH HOH A . U 8 HOH 333 1033 2006 HOH HOH A . U 8 HOH 334 1034 2013 HOH HOH A . U 8 HOH 335 1035 2130 HOH HOH A . U 8 HOH 336 1036 2023 HOH HOH A . U 8 HOH 337 1037 2272 HOH HOH A . U 8 HOH 338 1038 2034 HOH HOH A . U 8 HOH 339 1039 2103 HOH HOH A . U 8 HOH 340 1040 2144 HOH HOH A . U 8 HOH 341 1041 2004 HOH HOH A . U 8 HOH 342 1042 2119 HOH HOH A . U 8 HOH 343 1043 2020 HOH HOH A . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 57 A ASN 57 ? ASN 'GLYCOSYLATION SITE' 2 A ASN 106 A ASN 106 ? ASN 'GLYCOSYLATION SITE' 3 A ASN 241 A ASN 241 ? ASN 'GLYCOSYLATION SITE' 4 A ASN 256 A ASN 256 ? ASN 'GLYCOSYLATION SITE' 5 A ASN 341 A ASN 341 ? ASN 'GLYCOSYLATION SITE' 6 A ASN 485 A ASN 485 ? ASN 'GLYCOSYLATION SITE' # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_and_software_defined_assembly _pdbx_struct_assembly.method_details PISA _pdbx_struct_assembly.oligomeric_details octameric _pdbx_struct_assembly.oligomeric_count 8 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1,2,3,4,5,6,7,8 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 1 'ABSA (A^2)' 47540 ? 1 MORE -334.6 ? 1 'SSA (A^2)' 153490 ? # loop_ _pdbx_struct_oper_list.id _pdbx_struct_oper_list.type _pdbx_struct_oper_list.name _pdbx_struct_oper_list.symmetry_operation _pdbx_struct_oper_list.matrix[1][1] _pdbx_struct_oper_list.matrix[1][2] _pdbx_struct_oper_list.matrix[1][3] _pdbx_struct_oper_list.vector[1] _pdbx_struct_oper_list.matrix[2][1] _pdbx_struct_oper_list.matrix[2][2] _pdbx_struct_oper_list.matrix[2][3] _pdbx_struct_oper_list.vector[2] _pdbx_struct_oper_list.matrix[3][1] _pdbx_struct_oper_list.matrix[3][2] _pdbx_struct_oper_list.matrix[3][3] _pdbx_struct_oper_list.vector[3] 1 'identity operation' 1_555 x,y,z 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 2 'crystal symmetry operation' 6_555 x,-y,-z 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 3 'crystal symmetry operation' 2_555 -x,-y,z -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 4 'crystal symmetry operation' 5_555 -x,y,-z -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 5 'crystal symmetry operation' 3_555 -y,x,z 0.0000000000 -1.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 6 'crystal symmetry operation' 4_555 y,-x,z 0.0000000000 1.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 7 'crystal symmetry operation' 7_555 y,x,-z 0.0000000000 1.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 8 'crystal symmetry operation' 8_555 -y,-x,-z 0.0000000000 -1.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 # _pdbx_struct_special_symmetry.id 1 _pdbx_struct_special_symmetry.PDB_model_num 1 _pdbx_struct_special_symmetry.auth_asym_id A _pdbx_struct_special_symmetry.auth_comp_id NA _pdbx_struct_special_symmetry.auth_seq_id 602 _pdbx_struct_special_symmetry.PDB_ins_code ? _pdbx_struct_special_symmetry.label_asym_id C _pdbx_struct_special_symmetry.label_comp_id NA _pdbx_struct_special_symmetry.label_seq_id . # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2009-05-19 2 'Structure model' 1 1 2011-05-08 3 'Structure model' 1 2 2011-07-13 4 'Structure model' 1 3 2017-07-12 5 'Structure model' 1 4 2018-02-28 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Version format compliance' 2 3 'Structure model' 'Version format compliance' 3 4 'Structure model' Advisory 4 5 'Structure model' 'Database references' 5 5 'Structure model' 'Source and taxonomy' # loop_ _pdbx_audit_revision_category.ordinal _pdbx_audit_revision_category.revision_ordinal _pdbx_audit_revision_category.data_content_type _pdbx_audit_revision_category.category 1 4 'Structure model' database_PDB_caveat 2 5 'Structure model' citation 3 5 'Structure model' citation_author 4 5 'Structure model' entity_src_gen # loop_ _pdbx_audit_revision_item.ordinal _pdbx_audit_revision_item.revision_ordinal _pdbx_audit_revision_item.data_content_type _pdbx_audit_revision_item.item 1 5 'Structure model' '_citation.journal_abbrev' 2 5 'Structure model' '_citation.journal_id_ISSN' 3 5 'Structure model' '_citation.page_last' 4 5 'Structure model' '_citation.title' 5 5 'Structure model' '_citation_author.name' 6 5 'Structure model' '_entity_src_gen.pdbx_host_org_cell_line' 7 5 'Structure model' '_entity_src_gen.pdbx_host_org_strain' # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal REFMAC refinement 5.4.0069 ? 1 XDS 'data reduction' . ? 2 XSCALE 'data scaling' . ? 3 XDS phasing . ? 4 # _pdbx_entry_details.entry_id 2WIG _pdbx_entry_details.compound_details ;ENGINEERED RESIDUE IN CHAIN A, ASN 45 TO GLN ENGINEERED RESIDUE IN CHAIN A, ASN 483 TO GLN ENGINEERED RESIDUE IN CHAIN A, ASN 509 TO GLN ; _pdbx_entry_details.source_details ? _pdbx_entry_details.nonpolymer_details ? _pdbx_entry_details.sequence_details ? # loop_ _pdbx_validate_close_contact.id _pdbx_validate_close_contact.PDB_model_num _pdbx_validate_close_contact.auth_atom_id_1 _pdbx_validate_close_contact.auth_asym_id_1 _pdbx_validate_close_contact.auth_comp_id_1 _pdbx_validate_close_contact.auth_seq_id_1 _pdbx_validate_close_contact.PDB_ins_code_1 _pdbx_validate_close_contact.label_alt_id_1 _pdbx_validate_close_contact.auth_atom_id_2 _pdbx_validate_close_contact.auth_asym_id_2 _pdbx_validate_close_contact.auth_comp_id_2 _pdbx_validate_close_contact.auth_seq_id_2 _pdbx_validate_close_contact.PDB_ins_code_2 _pdbx_validate_close_contact.label_alt_id_2 _pdbx_validate_close_contact.dist 1 1 O A HOH 910 ? ? O A HOH 1013 ? ? 2.04 2 1 N A ASN 106 ? ? O A HOH 701 ? ? 2.09 3 1 O4 A SO4 603 ? ? O A HOH 702 ? ? 2.10 4 1 N A THR 496 ? ? O A HOH 703 ? ? 2.12 5 1 NH2 A ARG 509 ? ? O A HOH 704 ? ? 2.13 # _pdbx_validate_rmsd_angle.id 1 _pdbx_validate_rmsd_angle.PDB_model_num 1 _pdbx_validate_rmsd_angle.auth_atom_id_1 C _pdbx_validate_rmsd_angle.auth_asym_id_1 A _pdbx_validate_rmsd_angle.auth_comp_id_1 PHE _pdbx_validate_rmsd_angle.auth_seq_id_1 358 _pdbx_validate_rmsd_angle.PDB_ins_code_1 ? _pdbx_validate_rmsd_angle.label_alt_id_1 ? _pdbx_validate_rmsd_angle.auth_atom_id_2 N _pdbx_validate_rmsd_angle.auth_asym_id_2 A _pdbx_validate_rmsd_angle.auth_comp_id_2 PRO _pdbx_validate_rmsd_angle.auth_seq_id_2 359 _pdbx_validate_rmsd_angle.PDB_ins_code_2 ? _pdbx_validate_rmsd_angle.label_alt_id_2 ? _pdbx_validate_rmsd_angle.auth_atom_id_3 CA _pdbx_validate_rmsd_angle.auth_asym_id_3 A _pdbx_validate_rmsd_angle.auth_comp_id_3 PRO _pdbx_validate_rmsd_angle.auth_seq_id_3 359 _pdbx_validate_rmsd_angle.PDB_ins_code_3 ? _pdbx_validate_rmsd_angle.label_alt_id_3 ? _pdbx_validate_rmsd_angle.angle_value 132.45 _pdbx_validate_rmsd_angle.angle_target_value 119.30 _pdbx_validate_rmsd_angle.angle_deviation 13.15 _pdbx_validate_rmsd_angle.angle_standard_deviation 1.50 _pdbx_validate_rmsd_angle.linker_flag Y # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 THR A 53 ? ? 178.18 64.13 2 1 ASP A 54 ? ? 100.77 120.96 3 1 ALA A 58 ? ? -103.59 73.59 4 1 GLN A 67 ? ? -174.79 148.54 5 1 ASN A 106 ? ? -163.07 61.61 6 1 PRO A 160 ? ? -69.15 0.30 7 1 ASN A 165 ? ? 58.33 15.87 8 1 SER A 198 ? ? 52.42 -121.96 9 1 VAL A 279 ? ? -59.88 -0.61 10 1 ASP A 297 ? ? -134.39 -78.39 11 1 ASP A 324 ? ? -114.66 53.93 12 1 ILE A 344 ? ? -59.70 104.37 13 1 PRO A 359 ? ? -20.95 -59.50 14 1 VAL A 361 ? ? 51.50 80.61 15 1 SER A 362 ? ? -48.52 156.32 16 1 ASP A 379 ? ? -56.84 10.76 17 1 GLN A 380 ? ? -77.91 -71.02 18 1 ARG A 381 ? ? -20.83 110.68 19 1 PHE A 398 ? ? -125.38 -55.74 20 1 ARG A 453 ? ? -54.57 -6.75 21 1 THR A 496 ? ? 93.62 -90.97 22 1 GLU A 506 ? ? -70.02 -84.95 # _pdbx_validate_peptide_omega.id 1 _pdbx_validate_peptide_omega.PDB_model_num 1 _pdbx_validate_peptide_omega.auth_comp_id_1 GLY _pdbx_validate_peptide_omega.auth_asym_id_1 A _pdbx_validate_peptide_omega.auth_seq_id_1 360 _pdbx_validate_peptide_omega.PDB_ins_code_1 ? _pdbx_validate_peptide_omega.label_alt_id_1 ? _pdbx_validate_peptide_omega.auth_comp_id_2 VAL _pdbx_validate_peptide_omega.auth_asym_id_2 A _pdbx_validate_peptide_omega.auth_seq_id_2 361 _pdbx_validate_peptide_omega.PDB_ins_code_2 ? _pdbx_validate_peptide_omega.label_alt_id_2 ? _pdbx_validate_peptide_omega.omega 34.23 # _pdbx_validate_chiral.id 1 _pdbx_validate_chiral.PDB_model_num 1 _pdbx_validate_chiral.auth_atom_id CA _pdbx_validate_chiral.label_alt_id ? _pdbx_validate_chiral.auth_asym_id A _pdbx_validate_chiral.auth_comp_id VAL _pdbx_validate_chiral.auth_seq_id 361 _pdbx_validate_chiral.PDB_ins_code ? _pdbx_validate_chiral.details PLANAR _pdbx_validate_chiral.omega . # _pdbx_unobs_or_zero_occ_atoms.id 1 _pdbx_unobs_or_zero_occ_atoms.PDB_model_num 1 _pdbx_unobs_or_zero_occ_atoms.polymer_flag Y _pdbx_unobs_or_zero_occ_atoms.occupancy_flag 1 _pdbx_unobs_or_zero_occ_atoms.auth_asym_id A _pdbx_unobs_or_zero_occ_atoms.auth_comp_id LYS _pdbx_unobs_or_zero_occ_atoms.auth_seq_id 528 _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code ? _pdbx_unobs_or_zero_occ_atoms.auth_atom_id CA _pdbx_unobs_or_zero_occ_atoms.label_alt_id ? _pdbx_unobs_or_zero_occ_atoms.label_asym_id A _pdbx_unobs_or_zero_occ_atoms.label_comp_id LYS _pdbx_unobs_or_zero_occ_atoms.label_seq_id 528 _pdbx_unobs_or_zero_occ_atoms.label_atom_id CA # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A GLU 1 ? A GLU 1 2 1 Y 1 A ASP 2 ? A ASP 2 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 'ETHYL HYDROGEN METHYLAMIDOPHOSPHATE' TC3 3 'SODIUM ION' NA 4 'SULFATE ION' SO4 5 'CHLORIDE ION' CL 6 N-ACETYL-D-GLUCOSAMINE NAG 7 BETA-L-FUCOSE FUL 8 water HOH #