data_2I35 # _entry.id 2I35 # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.286 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 2I35 RCSB RCSB039077 WWPDB D_1000039077 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.details _pdbx_database_related.content_type PDB 2I36 '2I36 is the crystal structure of trigonal form of ground-state rhodopsin determined at 4.10 angstrom resolution' unspecified PDB 2I37 '2I37 is the crystal structure of photoactivated rhodopsin determined at 4.15 angstrom resolution' unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 2I35 _pdbx_database_status.recvd_initial_deposition_date 2006-08-17 _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry ? _pdbx_database_status.pdb_format_compatible Y _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Stenkamp, R.E.' 1 'Le Trong, I.' 2 'Lodowski, D.T.' 3 'Salom, D.' 4 'Palczewski, K.' 5 # _citation.id primary _citation.title 'Crystal structure of a photoactivated deprotonated intermediate of rhodopsin.' _citation.journal_abbrev Proc.Natl.Acad.Sci.Usa _citation.journal_volume 103 _citation.page_first 16123 _citation.page_last 16128 _citation.year 2006 _citation.journal_id_ASTM PNASA6 _citation.country US _citation.journal_id_ISSN 0027-8424 _citation.journal_id_CSD 0040 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 17060607 _citation.pdbx_database_id_DOI 10.1073/pnas.0608022103 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Salom, D.' 1 primary 'Lodowski, D.T.' 2 primary 'Stenkamp, R.E.' 3 primary 'Trong, I.L.' 4 primary 'Golczak, M.' 5 primary 'Jastrzebska, B.' 6 primary 'Harris, T.' 7 primary 'Ballesteros, J.A.' 8 primary 'Palczewski, K.' 9 # _cell.entry_id 2I35 _cell.length_a 277.534 _cell.length_b 277.534 _cell.length_c 66.321 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 120.00 _cell.Z_PDB 18 _cell.pdbx_unique_axis ? _cell.length_a_esd ? _cell.length_b_esd ? _cell.length_c_esd ? _cell.angle_alpha_esd ? _cell.angle_beta_esd ? _cell.angle_gamma_esd ? # _symmetry.entry_id 2I35 _symmetry.space_group_name_H-M 'H 3 2' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 155 _symmetry.space_group_name_Hall ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer nat Rhodopsin 39057.492 1 ? ? ? ? 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 4 ? ? ? ? 3 non-polymer man BETA-D-MANNOSE 180.156 1 ? ? ? ? 4 non-polymer syn RETINAL 284.436 1 ? ? ? ? 5 non-polymer syn 'PALMITIC ACID' 256.424 2 ? ? ? ? # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer yes _entity_poly.pdbx_seq_one_letter_code ;(ACE)MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYI LLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIM GVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAA QQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRN CMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA ; _entity_poly.pdbx_seq_one_letter_code_can ;XMNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNL AVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAF TWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQE SATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVT TLCCGKNPLGDDEASTTVSKTETSQVAPA ; _entity_poly.pdbx_strand_id A _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 ACE n 1 2 MET n 1 3 ASN n 1 4 GLY n 1 5 THR n 1 6 GLU n 1 7 GLY n 1 8 PRO n 1 9 ASN n 1 10 PHE n 1 11 TYR n 1 12 VAL n 1 13 PRO n 1 14 PHE n 1 15 SER n 1 16 ASN n 1 17 LYS n 1 18 THR n 1 19 GLY n 1 20 VAL n 1 21 VAL n 1 22 ARG n 1 23 SER n 1 24 PRO n 1 25 PHE n 1 26 GLU n 1 27 ALA n 1 28 PRO n 1 29 GLN n 1 30 TYR n 1 31 TYR n 1 32 LEU n 1 33 ALA n 1 34 GLU n 1 35 PRO n 1 36 TRP n 1 37 GLN n 1 38 PHE n 1 39 SER n 1 40 MET n 1 41 LEU n 1 42 ALA n 1 43 ALA n 1 44 TYR n 1 45 MET n 1 46 PHE n 1 47 LEU n 1 48 LEU n 1 49 ILE n 1 50 MET n 1 51 LEU n 1 52 GLY n 1 53 PHE n 1 54 PRO n 1 55 ILE n 1 56 ASN n 1 57 PHE n 1 58 LEU n 1 59 THR n 1 60 LEU n 1 61 TYR n 1 62 VAL n 1 63 THR n 1 64 VAL n 1 65 GLN n 1 66 HIS n 1 67 LYS n 1 68 LYS n 1 69 LEU n 1 70 ARG n 1 71 THR n 1 72 PRO n 1 73 LEU n 1 74 ASN n 1 75 TYR n 1 76 ILE n 1 77 LEU n 1 78 LEU n 1 79 ASN n 1 80 LEU n 1 81 ALA n 1 82 VAL n 1 83 ALA n 1 84 ASP n 1 85 LEU n 1 86 PHE n 1 87 MET n 1 88 VAL n 1 89 PHE n 1 90 GLY n 1 91 GLY n 1 92 PHE n 1 93 THR n 1 94 THR n 1 95 THR n 1 96 LEU n 1 97 TYR n 1 98 THR n 1 99 SER n 1 100 LEU n 1 101 HIS n 1 102 GLY n 1 103 TYR n 1 104 PHE n 1 105 VAL n 1 106 PHE n 1 107 GLY n 1 108 PRO n 1 109 THR n 1 110 GLY n 1 111 CYS n 1 112 ASN n 1 113 LEU n 1 114 GLU n 1 115 GLY n 1 116 PHE n 1 117 PHE n 1 118 ALA n 1 119 THR n 1 120 LEU n 1 121 GLY n 1 122 GLY n 1 123 GLU n 1 124 ILE n 1 125 ALA n 1 126 LEU n 1 127 TRP n 1 128 SER n 1 129 LEU n 1 130 VAL n 1 131 VAL n 1 132 LEU n 1 133 ALA n 1 134 ILE n 1 135 GLU n 1 136 ARG n 1 137 TYR n 1 138 VAL n 1 139 VAL n 1 140 VAL n 1 141 CYS n 1 142 LYS n 1 143 PRO n 1 144 MET n 1 145 SER n 1 146 ASN n 1 147 PHE n 1 148 ARG n 1 149 PHE n 1 150 GLY n 1 151 GLU n 1 152 ASN n 1 153 HIS n 1 154 ALA n 1 155 ILE n 1 156 MET n 1 157 GLY n 1 158 VAL n 1 159 ALA n 1 160 PHE n 1 161 THR n 1 162 TRP n 1 163 VAL n 1 164 MET n 1 165 ALA n 1 166 LEU n 1 167 ALA n 1 168 CYS n 1 169 ALA n 1 170 ALA n 1 171 PRO n 1 172 PRO n 1 173 LEU n 1 174 VAL n 1 175 GLY n 1 176 TRP n 1 177 SER n 1 178 ARG n 1 179 TYR n 1 180 ILE n 1 181 PRO n 1 182 GLU n 1 183 GLY n 1 184 MET n 1 185 GLN n 1 186 CYS n 1 187 SER n 1 188 CYS n 1 189 GLY n 1 190 ILE n 1 191 ASP n 1 192 TYR n 1 193 TYR n 1 194 THR n 1 195 PRO n 1 196 HIS n 1 197 GLU n 1 198 GLU n 1 199 THR n 1 200 ASN n 1 201 ASN n 1 202 GLU n 1 203 SER n 1 204 PHE n 1 205 VAL n 1 206 ILE n 1 207 TYR n 1 208 MET n 1 209 PHE n 1 210 VAL n 1 211 VAL n 1 212 HIS n 1 213 PHE n 1 214 ILE n 1 215 ILE n 1 216 PRO n 1 217 LEU n 1 218 ILE n 1 219 VAL n 1 220 ILE n 1 221 PHE n 1 222 PHE n 1 223 CYS n 1 224 TYR n 1 225 GLY n 1 226 GLN n 1 227 LEU n 1 228 VAL n 1 229 PHE n 1 230 THR n 1 231 VAL n 1 232 LYS n 1 233 GLU n 1 234 ALA n 1 235 ALA n 1 236 ALA n 1 237 GLN n 1 238 GLN n 1 239 GLN n 1 240 GLU n 1 241 SER n 1 242 ALA n 1 243 THR n 1 244 THR n 1 245 GLN n 1 246 LYS n 1 247 ALA n 1 248 GLU n 1 249 LYS n 1 250 GLU n 1 251 VAL n 1 252 THR n 1 253 ARG n 1 254 MET n 1 255 VAL n 1 256 ILE n 1 257 ILE n 1 258 MET n 1 259 VAL n 1 260 ILE n 1 261 ALA n 1 262 PHE n 1 263 LEU n 1 264 ILE n 1 265 CYS n 1 266 TRP n 1 267 LEU n 1 268 PRO n 1 269 TYR n 1 270 ALA n 1 271 GLY n 1 272 VAL n 1 273 ALA n 1 274 PHE n 1 275 TYR n 1 276 ILE n 1 277 PHE n 1 278 THR n 1 279 HIS n 1 280 GLN n 1 281 GLY n 1 282 SER n 1 283 ASP n 1 284 PHE n 1 285 GLY n 1 286 PRO n 1 287 ILE n 1 288 PHE n 1 289 MET n 1 290 THR n 1 291 ILE n 1 292 PRO n 1 293 ALA n 1 294 PHE n 1 295 PHE n 1 296 ALA n 1 297 LYS n 1 298 THR n 1 299 SER n 1 300 ALA n 1 301 VAL n 1 302 TYR n 1 303 ASN n 1 304 PRO n 1 305 VAL n 1 306 ILE n 1 307 TYR n 1 308 ILE n 1 309 MET n 1 310 MET n 1 311 ASN n 1 312 LYS n 1 313 GLN n 1 314 PHE n 1 315 ARG n 1 316 ASN n 1 317 CYS n 1 318 MET n 1 319 VAL n 1 320 THR n 1 321 THR n 1 322 LEU n 1 323 CYS n 1 324 CYS n 1 325 GLY n 1 326 LYS n 1 327 ASN n 1 328 PRO n 1 329 LEU n 1 330 GLY n 1 331 ASP n 1 332 ASP n 1 333 GLU n 1 334 ALA n 1 335 SER n 1 336 THR n 1 337 THR n 1 338 VAL n 1 339 SER n 1 340 LYS n 1 341 THR n 1 342 GLU n 1 343 THR n 1 344 SER n 1 345 GLN n 1 346 VAL n 1 347 ALA n 1 348 PRO n 1 349 ALA n # _entity_src_nat.entity_id 1 _entity_src_nat.pdbx_src_id 1 _entity_src_nat.pdbx_alt_source_flag sample _entity_src_nat.pdbx_beg_seq_num ? _entity_src_nat.pdbx_end_seq_num ? _entity_src_nat.common_name cattle _entity_src_nat.pdbx_organism_scientific 'Bos taurus' _entity_src_nat.pdbx_ncbi_taxonomy_id 9913 _entity_src_nat.genus Bos _entity_src_nat.species ? _entity_src_nat.strain ? _entity_src_nat.tissue ? _entity_src_nat.tissue_fraction ? _entity_src_nat.pdbx_secretion ? _entity_src_nat.pdbx_fragment ? _entity_src_nat.pdbx_variant ? _entity_src_nat.pdbx_cell_line ? _entity_src_nat.pdbx_atcc ? _entity_src_nat.pdbx_cellular_location ? _entity_src_nat.pdbx_organ ? _entity_src_nat.pdbx_organelle ? _entity_src_nat.pdbx_cell ? _entity_src_nat.pdbx_plasmid_name ? _entity_src_nat.pdbx_plasmid_details ? _entity_src_nat.details ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code OPSD_BOVIN _struct_ref.pdbx_db_accession P02699 _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLA VADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFT WVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQES ATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTT LCCGKNPLGDDEASTTVSKTETSQVAPA ; _struct_ref.pdbx_align_begin 1 _struct_ref.pdbx_db_isoform ? # _struct_ref_seq.align_id 1 _struct_ref_seq.ref_id 1 _struct_ref_seq.pdbx_PDB_id_code 2I35 _struct_ref_seq.pdbx_strand_id A _struct_ref_seq.seq_align_beg 2 _struct_ref_seq.pdbx_seq_align_beg_ins_code ? _struct_ref_seq.seq_align_end 349 _struct_ref_seq.pdbx_seq_align_end_ins_code ? _struct_ref_seq.pdbx_db_accession P02699 _struct_ref_seq.db_align_beg 1 _struct_ref_seq.pdbx_db_align_beg_ins_code ? _struct_ref_seq.db_align_end 348 _struct_ref_seq.pdbx_db_align_end_ins_code ? _struct_ref_seq.pdbx_auth_seq_align_beg 1 _struct_ref_seq.pdbx_auth_seq_align_end 348 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ACE non-polymer . 'ACETYL GROUP' ? 'C2 H4 O' 44.053 ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 BMA D-saccharide . BETA-D-MANNOSE ? 'C6 H12 O6' 180.156 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PLM non-polymer . 'PALMITIC ACID' ? 'C16 H32 O2' 256.424 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 RET non-polymer . RETINAL ? 'C20 H28 O' 284.436 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 2I35 _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 6.6 _exptl_crystal.density_percent_sol 81.4 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION' _exptl_crystal_grow.temp 278 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 6.3 _exptl_crystal_grow.pdbx_details ;80 mM MES, pH 6.3, 110 mM N-nonyl-beta-D-glucoside, 200 mM zinc acetate, 16 mM beta-mercaptoethanol, 0.4% Merpol DA, 0.1% sodium azide, equilibrated against 3.0 M ammonium sulfate, VAPOR DIFFUSION, temperature 278K ; _exptl_crystal_grow.pdbx_pH_range . # _diffrn.id 1 _diffrn.ambient_temp 77 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type 'ADSC QUANTUM 315' _diffrn_detector.pdbx_collection_date 2004-06-24 _diffrn_detector.details ? # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator ? _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 1.00000 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'ALS BEAMLINE 5.0.1' _diffrn_source.pdbx_synchrotron_site ALS _diffrn_source.pdbx_synchrotron_beamline 5.0.1 _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list 1.00000 # _reflns.entry_id 2I35 _reflns.observed_criterion_sigma_I 0 _reflns.observed_criterion_sigma_F 0 _reflns.d_resolution_low 50 _reflns.d_resolution_high 3.8 _reflns.number_obs 8204 _reflns.number_all 8204 _reflns.percent_possible_obs 84.5 _reflns.pdbx_Rmerge_I_obs 0.092 _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI 22.3 _reflns.B_iso_Wilson_estimate 227 _reflns.pdbx_redundancy 15.9 _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # _reflns_shell.d_res_high 3.80 _reflns_shell.d_res_low 3.94 _reflns_shell.percent_possible_all 59.2 _reflns_shell.Rmerge_I_obs ? _reflns_shell.pdbx_Rsym_value ? _reflns_shell.meanI_over_sigI_obs 1.3 _reflns_shell.pdbx_redundancy 9.1 _reflns_shell.percent_possible_obs ? _reflns_shell.number_unique_all 565 _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_unique_obs ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 # _refine.entry_id 2I35 _refine.ls_number_reflns_obs 8168 _refine.ls_number_reflns_all 8168 _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F 0 _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 30.00 _refine.ls_d_res_high 3.80 _refine.ls_percent_reflns_obs 84.53 _refine.ls_R_factor_obs 0.37542 _refine.ls_R_factor_all 0.37542 _refine.ls_R_factor_R_work 0.37333 _refine.ls_R_factor_R_free 0.41841 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 4.9 _refine.ls_number_reflns_R_free 401 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc 0.873 _refine.correlation_coeff_Fo_to_Fc_free 0.799 _refine.B_iso_mean 225.817 _refine.aniso_B[1][1] -22.65 _refine.aniso_B[2][2] -22.65 _refine.aniso_B[3][3] 33.98 _refine.aniso_B[1][2] -11.33 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_details MASK _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.20 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details 'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' _refine.pdbx_starting_model 'PDB entry 1HZX' _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R ? _refine.pdbx_overall_ESU_R_Free 1.013 _refine.overall_SU_ML 1.444 _refine.overall_SU_B 107.468 _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_phase_error ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 2606 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 121 _refine_hist.number_atoms_solvent 0 _refine_hist.number_atoms_total 2727 _refine_hist.d_res_high 3.80 _refine_hist.d_res_low 30.00 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function r_bond_refined_d 0.009 0.022 ? 2812 'X-RAY DIFFRACTION' ? r_bond_other_d ? ? ? ? 'X-RAY DIFFRACTION' ? r_angle_refined_deg 1.437 1.986 ? 3823 'X-RAY DIFFRACTION' ? r_angle_other_deg ? ? ? ? 'X-RAY DIFFRACTION' ? r_dihedral_angle_1_deg 6.009 5.000 ? 326 'X-RAY DIFFRACTION' ? r_dihedral_angle_2_deg 39.196 23.333 ? 111 'X-RAY DIFFRACTION' ? r_dihedral_angle_3_deg 20.123 15.000 ? 411 'X-RAY DIFFRACTION' ? r_dihedral_angle_4_deg 20.560 15.000 ? 7 'X-RAY DIFFRACTION' ? r_chiral_restr 0.126 0.200 ? 431 'X-RAY DIFFRACTION' ? r_gen_planes_refined 0.003 0.020 ? 2078 'X-RAY DIFFRACTION' ? r_gen_planes_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbd_refined 0.244 0.200 ? 1648 'X-RAY DIFFRACTION' ? r_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_refined 0.316 0.200 ? 1952 'X-RAY DIFFRACTION' ? r_nbtor_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_refined 0.185 0.200 ? 108 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_refined 0.313 0.200 ? 49 'X-RAY DIFFRACTION' ? r_symmetry_vdw_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_refined 0.194 0.200 ? 5 'X-RAY DIFFRACTION' ? r_symmetry_hbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcbond_it ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcangle_it ? ? ? ? 'X-RAY DIFFRACTION' ? r_scbond_it ? ? ? ? 'X-RAY DIFFRACTION' ? r_scangle_it ? ? ? ? 'X-RAY DIFFRACTION' ? r_rigid_bond_restr ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_free ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_bonded ? ? ? ? 'X-RAY DIFFRACTION' ? # _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.d_res_high 3.800 _refine_ls_shell.d_res_low 3.897 _refine_ls_shell.number_reflns_R_work 372 _refine_ls_shell.R_factor_R_work 0.604 _refine_ls_shell.percent_reflns_obs 56.81 _refine_ls_shell.R_factor_R_free 0.393 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.number_reflns_R_free 24 _refine_ls_shell.number_reflns_all ? _refine_ls_shell.R_factor_all ? _refine_ls_shell.number_reflns_obs 372 _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' # _struct.entry_id 2I35 _struct.title 'Crystal structure of rhombohedral crystal form of ground-state rhodopsin' _struct.pdbx_descriptor Rhodopsin _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 2I35 _struct_keywords.pdbx_keywords 'MEMBRANE PROTEIN' _struct_keywords.text 'trans-membrane protein, MEMBRANE PROTEIN' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 2 ? D N N 3 ? E N N 2 ? F N N 2 ? G N N 4 ? H N N 5 ? I N N 5 ? # _struct_biol.id 1 # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 PRO A 28 ? ALA A 33 ? PRO A 27 ALA A 32 5 ? 6 HELX_P HELX_P2 2 GLU A 34 ? HIS A 66 ? GLU A 33 HIS A 65 1 ? 33 HELX_P HELX_P3 3 THR A 71 ? GLY A 90 ? THR A 70 GLY A 89 1 ? 20 HELX_P HELX_P4 4 GLY A 90 ? LEU A 100 ? GLY A 89 LEU A 99 1 ? 11 HELX_P HELX_P5 5 PHE A 106 ? CYS A 141 ? PHE A 105 CYS A 140 1 ? 36 HELX_P HELX_P6 6 ASN A 152 ? ALA A 170 ? ASN A 151 ALA A 169 1 ? 19 HELX_P HELX_P7 7 ALA A 170 ? GLY A 175 ? ALA A 169 GLY A 174 1 ? 6 HELX_P HELX_P8 8 ASN A 200 ? PHE A 213 ? ASN A 199 PHE A 212 1 ? 14 HELX_P HELX_P9 9 PHE A 213 ? ALA A 234 ? PHE A 212 ALA A 233 1 ? 22 HELX_P HELX_P10 10 SER A 241 ? HIS A 279 ? SER A 240 HIS A 278 1 ? 39 HELX_P HELX_P11 11 PRO A 286 ? LYS A 297 ? PRO A 285 LYS A 296 1 ? 12 HELX_P HELX_P12 12 THR A 298 ? ALA A 300 ? THR A 297 ALA A 299 5 ? 3 HELX_P HELX_P13 13 VAL A 301 ? ASN A 311 ? VAL A 300 ASN A 310 1 ? 11 HELX_P HELX_P14 14 ASN A 311 ? CYS A 324 ? ASN A 310 CYS A 323 1 ? 14 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 111 SG ? ? ? 1_555 A CYS 188 SG ? ? A CYS 110 A CYS 187 1_555 ? ? ? ? ? ? ? 2.040 ? covale1 covale ? ? A ASN 3 ND2 ? ? ? 1_555 E NAG . C1 ? ? A ASN 2 A NAG 1338 1_555 ? ? ? ? ? ? ? 1.449 ? covale2 covale ? ? A ASN 16 ND2 ? ? ? 1_555 B NAG . C1 ? ? A ASN 15 A NAG 1335 1_555 ? ? ? ? ? ? ? 1.450 ? covale3 covale ? ? B NAG . O4 ? ? ? 1_555 C NAG . C1 ? ? A NAG 1335 A NAG 1336 1_555 ? ? ? ? ? ? ? 1.455 ? covale4 covale ? ? C NAG . O4 ? ? ? 1_555 D BMA . C1 ? ? A NAG 1336 A BMA 1337 1_555 ? ? ? ? ? ? ? 1.461 ? covale5 covale ? ? E NAG . O4 ? ? ? 1_555 F NAG . C1 ? ? A NAG 1338 A NAG 1339 1_555 ? ? ? ? ? ? ? 1.453 ? covale6 covale ? ? A ACE 1 C ? ? ? 1_555 A MET 2 N ? ? A ACE 0 A MET 1 1_555 ? ? ? ? ? ? ? 1.333 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? # _struct_sheet.id A _struct_sheet.type ? _struct_sheet.number_strands 2 _struct_sheet.details ? # _struct_sheet_order.sheet_id A _struct_sheet_order.range_id_1 1 _struct_sheet_order.range_id_2 2 _struct_sheet_order.offset ? _struct_sheet_order.sense anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 TYR A 179 ? GLU A 182 ? TYR A 178 GLU A 181 A 2 SER A 187 ? ILE A 190 ? SER A 186 ILE A 189 # _pdbx_struct_sheet_hbond.sheet_id A _pdbx_struct_sheet_hbond.range_id_1 1 _pdbx_struct_sheet_hbond.range_id_2 2 _pdbx_struct_sheet_hbond.range_1_label_atom_id N _pdbx_struct_sheet_hbond.range_1_label_comp_id GLU _pdbx_struct_sheet_hbond.range_1_label_asym_id A _pdbx_struct_sheet_hbond.range_1_label_seq_id 182 _pdbx_struct_sheet_hbond.range_1_PDB_ins_code ? _pdbx_struct_sheet_hbond.range_1_auth_atom_id N _pdbx_struct_sheet_hbond.range_1_auth_comp_id GLU _pdbx_struct_sheet_hbond.range_1_auth_asym_id A _pdbx_struct_sheet_hbond.range_1_auth_seq_id 181 _pdbx_struct_sheet_hbond.range_2_label_atom_id O _pdbx_struct_sheet_hbond.range_2_label_comp_id SER _pdbx_struct_sheet_hbond.range_2_label_asym_id A _pdbx_struct_sheet_hbond.range_2_label_seq_id 187 _pdbx_struct_sheet_hbond.range_2_PDB_ins_code ? _pdbx_struct_sheet_hbond.range_2_auth_atom_id O _pdbx_struct_sheet_hbond.range_2_auth_comp_id SER _pdbx_struct_sheet_hbond.range_2_auth_asym_id A _pdbx_struct_sheet_hbond.range_2_auth_seq_id 186 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 8 'BINDING SITE FOR RESIDUE NAG A 1335' AC2 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE NAG A 1336' AC3 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE BMA A 1337' AC4 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE NAG A 1338' AC5 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE NAG A 1339' AC6 Software ? ? ? ? 11 'BINDING SITE FOR RESIDUE RET A 1332' AC7 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE PLM A 1333' AC8 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE PLM A 1334' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 8 THR A 5 ? THR A 4 . ? 1_555 ? 2 AC1 8 PRO A 8 ? PRO A 7 . ? 12_555 ? 3 AC1 8 ASN A 16 ? ASN A 15 . ? 1_555 ? 4 AC1 8 ASN A 16 ? ASN A 15 . ? 12_555 ? 5 AC1 8 GLY A 19 ? GLY A 18 . ? 1_555 ? 6 AC1 8 VAL A 21 ? VAL A 20 . ? 1_555 ? 7 AC1 8 NAG C . ? NAG A 1336 . ? 12_555 ? 8 AC1 8 NAG C . ? NAG A 1336 . ? 1_555 ? 9 AC2 5 ARG A 22 ? ARG A 21 . ? 1_555 ? 10 AC2 5 GLU A 26 ? GLU A 25 . ? 12_555 ? 11 AC2 5 NAG B . ? NAG A 1335 . ? 12_555 ? 12 AC2 5 NAG B . ? NAG A 1335 . ? 1_555 ? 13 AC2 5 BMA D . ? BMA A 1337 . ? 1_555 ? 14 AC3 1 NAG C . ? NAG A 1336 . ? 1_555 ? 15 AC4 6 ACE A 1 ? ACE A 0 . ? 1_555 ? 16 AC4 6 ASN A 3 ? ASN A 2 . ? 1_555 ? 17 AC4 6 GLN A 280 ? GLN A 279 . ? 12_555 ? 18 AC4 6 GLY A 281 ? GLY A 280 . ? 12_555 ? 19 AC4 6 ASP A 283 ? ASP A 282 . ? 1_555 ? 20 AC4 6 NAG F . ? NAG A 1339 . ? 1_555 ? 21 AC5 1 NAG E . ? NAG A 1338 . ? 1_555 ? 22 AC6 11 ALA A 118 ? ALA A 117 . ? 1_555 ? 23 AC6 11 THR A 119 ? THR A 118 . ? 1_555 ? 24 AC6 11 GLY A 122 ? GLY A 121 . ? 1_555 ? 25 AC6 11 TYR A 192 ? TYR A 191 . ? 1_555 ? 26 AC6 11 MET A 208 ? MET A 207 . ? 1_555 ? 27 AC6 11 PHE A 213 ? PHE A 212 . ? 1_555 ? 28 AC6 11 PHE A 262 ? PHE A 261 . ? 1_555 ? 29 AC6 11 TRP A 266 ? TRP A 265 . ? 1_555 ? 30 AC6 11 TYR A 269 ? TYR A 268 . ? 1_555 ? 31 AC6 11 ALA A 293 ? ALA A 292 . ? 1_555 ? 32 AC6 11 LYS A 297 ? LYS A 296 . ? 1_555 ? 33 AC7 4 LEU A 51 ? LEU A 50 . ? 1_555 ? 34 AC7 4 PRO A 54 ? PRO A 53 . ? 1_555 ? 35 AC7 4 ILE A 55 ? ILE A 54 . ? 1_555 ? 36 AC7 4 PLM I . ? PLM A 1334 . ? 1_555 ? 37 AC8 6 PHE A 53 ? PHE A 52 . ? 1_555 ? 38 AC8 6 PRO A 54 ? PRO A 53 . ? 1_555 ? 39 AC8 6 LEU A 58 ? LEU A 57 . ? 1_555 ? 40 AC8 6 LEU A 322 ? LEU A 321 . ? 1_555 ? 41 AC8 6 CYS A 323 ? CYS A 322 . ? 1_555 ? 42 AC8 6 PLM H . ? PLM A 1333 . ? 1_555 ? # _database_PDB_matrix.entry_id 2I35 _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 2I35 _atom_sites.fract_transf_matrix[1][1] 0.003603 _atom_sites.fract_transf_matrix[1][2] 0.002080 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.004161 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.015078 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num HETATM 1 C C . ACE A 1 1 ? 17.583 127.070 13.924 1.00 227.22 ? 0 ACE A C 1 HETATM 2 O O . ACE A 1 1 ? 18.778 126.809 13.735 1.00 227.22 ? 0 ACE A O 1 HETATM 3 C CH3 . ACE A 1 1 ? 16.854 126.675 15.193 1.00 227.22 ? 0 ACE A CH3 1 ATOM 4 N N . MET A 1 2 ? 16.950 127.941 13.138 1.00 227.22 ? 1 MET A N 1 ATOM 5 C CA . MET A 1 2 ? 17.270 129.367 13.141 1.00 227.22 ? 1 MET A CA 1 ATOM 6 C C . MET A 1 2 ? 18.303 129.753 14.213 1.00 227.22 ? 1 MET A C 1 ATOM 7 O O . MET A 1 2 ? 17.944 129.978 15.372 1.00 227.22 ? 1 MET A O 1 ATOM 8 C CB . MET A 1 2 ? 15.991 130.200 13.317 1.00 227.22 ? 1 MET A CB 1 ATOM 9 C CG . MET A 1 2 ? 14.815 129.807 12.418 1.00 227.22 ? 1 MET A CG 1 ATOM 10 S SD . MET A 1 2 ? 15.166 129.678 10.642 1.00 227.22 ? 1 MET A SD 1 ATOM 11 C CE . MET A 1 2 ? 15.125 131.388 10.101 1.00 227.22 ? 1 MET A CE 1 ATOM 12 N N . ASN A 1 3 ? 19.578 129.815 13.825 1.00 227.22 ? 2 ASN A N 1 ATOM 13 C CA . ASN A 1 3 ? 20.671 130.165 14.753 1.00 227.22 ? 2 ASN A CA 1 ATOM 14 C C . ASN A 1 3 ? 21.125 131.632 14.668 1.00 227.22 ? 2 ASN A C 1 ATOM 15 O O . ASN A 1 3 ? 22.074 132.041 15.343 1.00 227.22 ? 2 ASN A O 1 ATOM 16 C CB . ASN A 1 3 ? 21.872 129.217 14.580 1.00 227.22 ? 2 ASN A CB 1 ATOM 17 C CG . ASN A 1 3 ? 21.574 127.787 15.027 1.00 227.22 ? 2 ASN A CG 1 ATOM 18 O OD1 . ASN A 1 3 ? 20.946 127.564 16.066 1.00 227.22 ? 2 ASN A OD1 1 ATOM 19 N ND2 . ASN A 1 3 ? 22.042 126.811 14.238 1.00 227.22 ? 2 ASN A ND2 1 ATOM 20 N N . GLY A 1 4 ? 20.435 132.415 13.840 1.00 227.22 ? 3 GLY A N 1 ATOM 21 C CA . GLY A 1 4 ? 20.726 133.836 13.655 1.00 227.22 ? 3 GLY A CA 1 ATOM 22 C C . GLY A 1 4 ? 19.506 134.552 13.104 1.00 227.22 ? 3 GLY A C 1 ATOM 23 O O . GLY A 1 4 ? 18.471 134.610 13.769 1.00 227.22 ? 3 GLY A O 1 ATOM 24 N N . THR A 1 5 ? 19.624 135.084 11.884 1.00 227.22 ? 4 THR A N 1 ATOM 25 C CA . THR A 1 5 ? 18.487 135.649 11.131 1.00 227.22 ? 4 THR A CA 1 ATOM 26 C C . THR A 1 5 ? 18.798 135.742 9.630 1.00 227.22 ? 4 THR A C 1 ATOM 27 O O . THR A 1 5 ? 19.946 135.949 9.250 1.00 227.22 ? 4 THR A O 1 ATOM 28 C CB . THR A 1 5 ? 18.057 137.031 11.675 1.00 227.22 ? 4 THR A CB 1 ATOM 29 O OG1 . THR A 1 5 ? 17.886 136.949 13.095 1.00 227.22 ? 4 THR A OG1 1 ATOM 30 C CG2 . THR A 1 5 ? 16.740 137.488 11.043 1.00 227.22 ? 4 THR A CG2 1 ATOM 31 N N . GLU A 1 6 ? 17.776 135.580 8.786 1.00 227.22 ? 5 GLU A N 1 ATOM 32 C CA . GLU A 1 6 ? 17.936 135.681 7.326 1.00 227.22 ? 5 GLU A CA 1 ATOM 33 C C . GLU A 1 6 ? 16.993 136.720 6.693 1.00 227.22 ? 5 GLU A C 1 ATOM 34 O O . GLU A 1 6 ? 15.806 136.776 7.025 1.00 227.22 ? 5 GLU A O 1 ATOM 35 C CB . GLU A 1 6 ? 17.729 134.311 6.674 1.00 227.22 ? 5 GLU A CB 1 ATOM 36 C CG . GLU A 1 6 ? 18.487 134.105 5.370 1.00 227.22 ? 5 GLU A CG 1 ATOM 37 C CD . GLU A 1 6 ? 18.651 132.632 5.019 1.00 227.22 ? 5 GLU A CD 1 ATOM 38 O OE1 . GLU A 1 6 ? 17.633 131.924 4.870 1.00 227.22 ? 5 GLU A OE1 1 ATOM 39 O OE2 . GLU A 1 6 ? 19.804 132.174 4.889 1.00 227.22 ? 5 GLU A OE2 1 ATOM 40 N N . GLY A 1 7 ? 17.534 137.533 5.783 1.00 227.22 ? 6 GLY A N 1 ATOM 41 C CA . GLY A 1 7 ? 16.761 138.569 5.079 1.00 227.22 ? 6 GLY A CA 1 ATOM 42 C C . GLY A 1 7 ? 17.087 138.681 3.590 1.00 227.22 ? 6 GLY A C 1 ATOM 43 O O . GLY A 1 7 ? 17.700 137.769 3.021 1.00 227.22 ? 6 GLY A O 1 ATOM 44 N N . PRO A 1 8 ? 16.670 139.792 2.938 1.00 227.22 ? 7 PRO A N 1 ATOM 45 C CA . PRO A 1 8 ? 16.986 140.002 1.524 1.00 227.22 ? 7 PRO A CA 1 ATOM 46 C C . PRO A 1 8 ? 18.486 140.101 1.276 1.00 227.22 ? 7 PRO A C 1 ATOM 47 O O . PRO A 1 8 ? 19.005 139.394 0.413 1.00 227.22 ? 7 PRO A O 1 ATOM 48 C CB . PRO A 1 8 ? 16.288 141.329 1.190 1.00 227.22 ? 7 PRO A CB 1 ATOM 49 C CG . PRO A 1 8 ? 16.108 142.010 2.489 1.00 227.22 ? 7 PRO A CG 1 ATOM 50 C CD . PRO A 1 8 ? 15.873 140.905 3.483 1.00 227.22 ? 7 PRO A CD 1 ATOM 51 N N . ASN A 1 9 ? 19.173 140.950 2.038 1.00 227.22 ? 8 ASN A N 1 ATOM 52 C CA . ASN A 1 9 ? 20.612 141.144 1.868 1.00 227.22 ? 8 ASN A CA 1 ATOM 53 C C . ASN A 1 9 ? 21.414 141.210 3.176 1.00 227.22 ? 8 ASN A C 1 ATOM 54 O O . ASN A 1 9 ? 22.370 141.985 3.281 1.00 227.22 ? 8 ASN A O 1 ATOM 55 C CB . ASN A 1 9 ? 20.892 142.367 0.975 1.00 227.22 ? 8 ASN A CB 1 ATOM 56 C CG . ASN A 1 9 ? 20.264 143.651 1.505 1.00 227.22 ? 8 ASN A CG 1 ATOM 57 O OD1 . ASN A 1 9 ? 19.376 143.629 2.362 1.00 227.22 ? 8 ASN A OD1 1 ATOM 58 N ND2 . ASN A 1 9 ? 20.727 144.783 0.983 1.00 227.22 ? 8 ASN A ND2 1 ATOM 59 N N . PHE A 1 10 ? 21.031 140.381 4.154 1.00 227.22 ? 9 PHE A N 1 ATOM 60 C CA . PHE A 1 10 ? 21.708 140.332 5.468 1.00 227.22 ? 9 PHE A CA 1 ATOM 61 C C . PHE A 1 10 ? 21.563 139.014 6.237 1.00 227.22 ? 9 PHE A C 1 ATOM 62 O O . PHE A 1 10 ? 20.585 138.283 6.064 1.00 227.22 ? 9 PHE A O 1 ATOM 63 C CB . PHE A 1 10 ? 21.266 141.499 6.369 1.00 227.22 ? 9 PHE A CB 1 ATOM 64 C CG . PHE A 1 10 ? 19.777 141.630 6.516 1.00 227.22 ? 9 PHE A CG 1 ATOM 65 C CD1 . PHE A 1 10 ? 19.072 140.805 7.382 1.00 227.22 ? 9 PHE A CD1 1 ATOM 66 C CD2 . PHE A 1 10 ? 19.079 142.587 5.791 1.00 227.22 ? 9 PHE A CD2 1 ATOM 67 C CE1 . PHE A 1 10 ? 17.695 140.927 7.519 1.00 227.22 ? 9 PHE A CE1 1 ATOM 68 C CE2 . PHE A 1 10 ? 17.701 142.715 5.923 1.00 227.22 ? 9 PHE A CE2 1 ATOM 69 C CZ . PHE A 1 10 ? 17.009 141.884 6.789 1.00 227.22 ? 9 PHE A CZ 1 ATOM 70 N N . TYR A 1 11 ? 22.555 138.735 7.086 1.00 227.22 ? 10 TYR A N 1 ATOM 71 C CA . TYR A 1 11 ? 22.528 137.621 8.039 1.00 227.22 ? 10 TYR A CA 1 ATOM 72 C C . TYR A 1 11 ? 23.161 138.072 9.345 1.00 227.22 ? 10 TYR A C 1 ATOM 73 O O . TYR A 1 11 ? 24.348 138.396 9.399 1.00 227.22 ? 10 TYR A O 1 ATOM 74 C CB . TYR A 1 11 ? 23.259 136.393 7.488 1.00 227.22 ? 10 TYR A CB 1 ATOM 75 C CG . TYR A 1 11 ? 23.291 135.174 8.403 1.00 227.22 ? 10 TYR A CG 1 ATOM 76 C CD1 . TYR A 1 11 ? 24.421 134.877 9.165 1.00 227.22 ? 10 TYR A CD1 1 ATOM 77 C CD2 . TYR A 1 11 ? 22.207 134.298 8.477 1.00 227.22 ? 10 TYR A CD2 1 ATOM 78 C CE1 . TYR A 1 11 ? 24.465 133.748 9.991 1.00 227.22 ? 10 TYR A CE1 1 ATOM 79 C CE2 . TYR A 1 11 ? 22.240 133.169 9.301 1.00 227.22 ? 10 TYR A CE2 1 ATOM 80 C CZ . TYR A 1 11 ? 23.371 132.900 10.052 1.00 227.22 ? 10 TYR A CZ 1 ATOM 81 O OH . TYR A 1 11 ? 23.407 131.787 10.859 1.00 227.22 ? 10 TYR A OH 1 ATOM 82 N N . VAL A 1 12 ? 22.349 138.093 10.394 1.00 227.22 ? 11 VAL A N 1 ATOM 83 C CA . VAL A 1 12 ? 22.779 138.517 11.716 1.00 227.22 ? 11 VAL A CA 1 ATOM 84 C C . VAL A 1 12 ? 22.791 137.297 12.647 1.00 227.22 ? 11 VAL A C 1 ATOM 85 O O . VAL A 1 12 ? 21.729 136.804 13.036 1.00 227.22 ? 11 VAL A O 1 ATOM 86 C CB . VAL A 1 12 ? 21.852 139.618 12.266 1.00 227.22 ? 11 VAL A CB 1 ATOM 87 C CG1 . VAL A 1 12 ? 22.330 140.088 13.623 1.00 227.22 ? 11 VAL A CG1 1 ATOM 88 C CG2 . VAL A 1 12 ? 21.769 140.792 11.292 1.00 227.22 ? 11 VAL A CG2 1 ATOM 89 N N . PRO A 1 13 ? 23.997 136.812 13.010 1.00 227.22 ? 12 PRO A N 1 ATOM 90 C CA . PRO A 1 13 ? 24.192 135.535 13.714 1.00 227.22 ? 12 PRO A CA 1 ATOM 91 C C . PRO A 1 13 ? 23.700 135.537 15.159 1.00 227.22 ? 12 PRO A C 1 ATOM 92 O O . PRO A 1 13 ? 24.444 135.174 16.076 1.00 227.22 ? 12 PRO A O 1 ATOM 93 C CB . PRO A 1 13 ? 25.713 135.338 13.666 1.00 227.22 ? 12 PRO A CB 1 ATOM 94 C CG . PRO A 1 13 ? 26.261 136.708 13.585 1.00 227.22 ? 12 PRO A CG 1 ATOM 95 C CD . PRO A 1 13 ? 25.280 137.493 12.755 1.00 227.22 ? 12 PRO A CD 1 ATOM 96 N N . PHE A 1 14 ? 22.446 135.936 15.347 1.00 227.22 ? 13 PHE A N 1 ATOM 97 C CA . PHE A 1 14 ? 21.840 135.998 16.669 1.00 227.22 ? 13 PHE A CA 1 ATOM 98 C C . PHE A 1 14 ? 20.356 135.672 16.592 1.00 227.22 ? 13 PHE A C 1 ATOM 99 O O . PHE A 1 14 ? 19.628 136.241 15.775 1.00 227.22 ? 13 PHE A O 1 ATOM 100 C CB . PHE A 1 14 ? 22.055 137.379 17.297 1.00 227.22 ? 13 PHE A CB 1 ATOM 101 C CG . PHE A 1 14 ? 21.940 137.388 18.797 1.00 227.22 ? 13 PHE A CG 1 ATOM 102 C CD1 . PHE A 1 14 ? 22.922 136.786 19.589 1.00 227.22 ? 13 PHE A CD1 1 ATOM 103 C CD2 . PHE A 1 14 ? 20.856 138.003 19.419 1.00 227.22 ? 13 PHE A CD2 1 ATOM 104 C CE1 . PHE A 1 14 ? 22.821 136.790 20.974 1.00 227.22 ? 13 PHE A CE1 1 ATOM 105 C CE2 . PHE A 1 14 ? 20.746 138.015 20.804 1.00 227.22 ? 13 PHE A CE2 1 ATOM 106 C CZ . PHE A 1 14 ? 21.730 137.407 21.584 1.00 227.22 ? 13 PHE A CZ 1 ATOM 107 N N . SER A 1 15 ? 19.923 134.758 17.456 1.00 227.22 ? 14 SER A N 1 ATOM 108 C CA . SER A 1 15 ? 18.563 134.229 17.441 1.00 227.22 ? 14 SER A CA 1 ATOM 109 C C . SER A 1 15 ? 17.512 135.333 17.632 1.00 227.22 ? 14 SER A C 1 ATOM 110 O O . SER A 1 15 ? 17.373 135.880 18.732 1.00 227.22 ? 14 SER A O 1 ATOM 111 C CB . SER A 1 15 ? 18.432 133.152 18.525 1.00 227.22 ? 14 SER A CB 1 ATOM 112 O OG . SER A 1 15 ? 18.008 131.911 17.985 1.00 227.22 ? 14 SER A OG 1 ATOM 113 N N . ASN A 1 16 ? 16.790 135.661 16.553 1.00 227.22 ? 15 ASN A N 1 ATOM 114 C CA . ASN A 1 16 ? 15.683 136.638 16.599 1.00 227.22 ? 15 ASN A CA 1 ATOM 115 C C . ASN A 1 16 ? 14.502 136.079 17.404 1.00 227.22 ? 15 ASN A C 1 ATOM 116 O O . ASN A 1 16 ? 13.338 136.415 17.147 1.00 227.22 ? 15 ASN A O 1 ATOM 117 C CB . ASN A 1 16 ? 15.242 137.077 15.181 1.00 227.22 ? 15 ASN A CB 1 ATOM 118 C CG . ASN A 1 16 ? 14.452 138.408 15.171 1.00 227.22 ? 15 ASN A CG 1 ATOM 119 O OD1 . ASN A 1 16 ? 14.823 139.369 15.837 1.00 227.22 ? 15 ASN A OD1 1 ATOM 120 N ND2 . ASN A 1 16 ? 13.369 138.454 14.390 1.00 227.22 ? 15 ASN A ND2 1 ATOM 121 N N . LYS A 1 17 ? 14.828 135.230 18.384 1.00 227.22 ? 16 LYS A N 1 ATOM 122 C CA . LYS A 1 17 ? 13.846 134.625 19.293 1.00 227.22 ? 16 LYS A CA 1 ATOM 123 C C . LYS A 1 17 ? 13.294 135.642 20.290 1.00 227.22 ? 16 LYS A C 1 ATOM 124 O O . LYS A 1 17 ? 12.214 135.452 20.861 1.00 227.22 ? 16 LYS A O 1 ATOM 125 C CB . LYS A 1 17 ? 14.444 133.406 20.019 1.00 227.22 ? 16 LYS A CB 1 ATOM 126 C CG . LYS A 1 17 ? 15.512 133.703 21.091 1.00 227.22 ? 16 LYS A CG 1 ATOM 127 C CD . LYS A 1 17 ? 16.229 132.423 21.556 1.00 227.22 ? 16 LYS A CD 1 ATOM 128 C CE . LYS A 1 17 ? 15.269 131.387 22.158 1.00 227.22 ? 16 LYS A CE 1 ATOM 129 N NZ . LYS A 1 17 ? 15.879 130.028 22.291 1.00 227.22 ? 16 LYS A NZ 1 ATOM 130 N N . THR A 1 18 ? 14.059 136.714 20.488 1.00 227.22 ? 17 THR A N 1 ATOM 131 C CA . THR A 1 18 ? 13.655 137.852 21.310 1.00 227.22 ? 17 THR A CA 1 ATOM 132 C C . THR A 1 18 ? 13.034 138.939 20.439 1.00 227.22 ? 17 THR A C 1 ATOM 133 O O . THR A 1 18 ? 12.462 139.910 20.947 1.00 227.22 ? 17 THR A O 1 ATOM 134 C CB . THR A 1 18 ? 14.857 138.451 22.067 1.00 227.22 ? 17 THR A CB 1 ATOM 135 O OG1 . THR A 1 18 ? 15.999 138.476 21.196 1.00 227.22 ? 17 THR A OG1 1 ATOM 136 C CG2 . THR A 1 18 ? 15.171 137.637 23.339 1.00 227.22 ? 17 THR A CG2 1 ATOM 137 N N . GLY A 1 19 ? 13.157 138.771 19.126 1.00 227.22 ? 18 GLY A N 1 ATOM 138 C CA . GLY A 1 19 ? 12.601 139.718 18.174 1.00 227.22 ? 18 GLY A CA 1 ATOM 139 C C . GLY A 1 19 ? 13.291 141.057 18.270 1.00 227.22 ? 18 GLY A C 1 ATOM 140 O O . GLY A 1 19 ? 12.748 142.076 17.844 1.00 227.22 ? 18 GLY A O 1 ATOM 141 N N . VAL A 1 20 ? 14.488 141.045 18.850 1.00 227.22 ? 19 VAL A N 1 ATOM 142 C CA . VAL A 1 20 ? 15.308 142.246 18.988 1.00 227.22 ? 19 VAL A CA 1 ATOM 143 C C . VAL A 1 20 ? 16.147 142.507 17.720 1.00 227.22 ? 19 VAL A C 1 ATOM 144 O O . VAL A 1 20 ? 16.616 143.633 17.489 1.00 227.22 ? 19 VAL A O 1 ATOM 145 C CB . VAL A 1 20 ? 16.205 142.184 20.271 1.00 227.22 ? 19 VAL A CB 1 ATOM 146 C CG1 . VAL A 1 20 ? 17.342 141.165 20.124 1.00 227.22 ? 19 VAL A CG1 1 ATOM 147 C CG2 . VAL A 1 20 ? 16.752 143.568 20.631 1.00 227.22 ? 19 VAL A CG2 1 ATOM 148 N N . VAL A 1 21 ? 16.308 141.465 16.899 1.00 227.22 ? 20 VAL A N 1 ATOM 149 C CA . VAL A 1 21 ? 17.180 141.519 15.727 1.00 227.22 ? 20 VAL A CA 1 ATOM 150 C C . VAL A 1 21 ? 16.584 142.392 14.634 1.00 227.22 ? 20 VAL A C 1 ATOM 151 O O . VAL A 1 21 ? 15.425 142.212 14.235 1.00 227.22 ? 20 VAL A O 1 ATOM 152 C CB . VAL A 1 21 ? 17.520 140.107 15.177 1.00 227.22 ? 20 VAL A CB 1 ATOM 153 C CG1 . VAL A 1 21 ? 18.266 140.201 13.860 1.00 227.22 ? 20 VAL A CG1 1 ATOM 154 C CG2 . VAL A 1 21 ? 18.343 139.321 16.185 1.00 227.22 ? 20 VAL A CG2 1 ATOM 155 N N . ARG A 1 22 ? 17.402 143.341 14.181 1.00 227.22 ? 21 ARG A N 1 ATOM 156 C CA . ARG A 1 22 ? 17.083 144.224 13.063 1.00 227.22 ? 21 ARG A CA 1 ATOM 157 C C . ARG A 1 22 ? 18.075 144.011 11.914 1.00 227.22 ? 21 ARG A C 1 ATOM 158 O O . ARG A 1 22 ? 19.029 143.235 12.032 1.00 227.22 ? 21 ARG A O 1 ATOM 159 C CB . ARG A 1 22 ? 17.144 145.694 13.505 1.00 227.22 ? 21 ARG A CB 1 ATOM 160 C CG . ARG A 1 22 ? 16.390 146.058 14.782 1.00 227.22 ? 21 ARG A CG 1 ATOM 161 C CD . ARG A 1 22 ? 14.958 146.499 14.508 1.00 227.22 ? 21 ARG A CD 1 ATOM 162 N NE . ARG A 1 22 ? 13.991 145.454 14.843 1.00 227.22 ? 21 ARG A NE 1 ATOM 163 C CZ . ARG A 1 22 ? 13.455 145.273 16.052 1.00 227.22 ? 21 ARG A CZ 1 ATOM 164 N NH1 . ARG A 1 22 ? 13.781 146.067 17.070 1.00 227.22 ? 21 ARG A NH1 1 ATOM 165 N NH2 . ARG A 1 22 ? 12.585 144.287 16.248 1.00 227.22 ? 21 ARG A NH2 1 ATOM 166 N N . SER A 1 23 ? 17.839 144.709 10.807 1.00 227.22 ? 22 SER A N 1 ATOM 167 C CA . SER A 1 23 ? 18.774 144.754 9.683 1.00 227.22 ? 22 SER A CA 1 ATOM 168 C C . SER A 1 23 ? 19.909 145.770 9.939 1.00 227.22 ? 22 SER A C 1 ATOM 169 O O . SER A 1 23 ? 19.672 146.842 10.510 1.00 227.22 ? 22 SER A O 1 ATOM 170 C CB . SER A 1 23 ? 18.020 145.087 8.387 1.00 227.22 ? 22 SER A CB 1 ATOM 171 O OG . SER A 1 23 ? 18.898 145.336 7.302 1.00 227.22 ? 22 SER A OG 1 ATOM 172 N N . PRO A 1 24 ? 21.149 145.431 9.522 1.00 227.22 ? 23 PRO A N 1 ATOM 173 C CA . PRO A 1 24 ? 22.302 146.325 9.669 1.00 227.22 ? 23 PRO A CA 1 ATOM 174 C C . PRO A 1 24 ? 22.265 147.500 8.692 1.00 227.22 ? 23 PRO A C 1 ATOM 175 O O . PRO A 1 24 ? 23.208 148.290 8.630 1.00 227.22 ? 23 PRO A O 1 ATOM 176 C CB . PRO A 1 24 ? 23.483 145.414 9.352 1.00 227.22 ? 23 PRO A CB 1 ATOM 177 C CG . PRO A 1 24 ? 22.923 144.409 8.419 1.00 227.22 ? 23 PRO A CG 1 ATOM 178 C CD . PRO A 1 24 ? 21.531 144.154 8.889 1.00 227.22 ? 23 PRO A CD 1 ATOM 179 N N . PHE A 1 25 ? 21.184 147.596 7.927 1.00 227.22 ? 24 PHE A N 1 ATOM 180 C CA . PHE A 1 25 ? 20.966 148.721 7.025 1.00 227.22 ? 24 PHE A CA 1 ATOM 181 C C . PHE A 1 25 ? 19.995 149.711 7.649 1.00 227.22 ? 24 PHE A C 1 ATOM 182 O O . PHE A 1 25 ? 19.914 150.864 7.214 1.00 227.22 ? 24 PHE A O 1 ATOM 183 C CB . PHE A 1 25 ? 20.415 148.253 5.666 1.00 227.22 ? 24 PHE A CB 1 ATOM 184 C CG . PHE A 1 25 ? 21.273 147.229 4.977 1.00 227.22 ? 24 PHE A CG 1 ATOM 185 C CD1 . PHE A 1 25 ? 22.561 147.550 4.549 1.00 227.22 ? 24 PHE A CD1 1 ATOM 186 C CD2 . PHE A 1 25 ? 20.788 145.945 4.749 1.00 227.22 ? 24 PHE A CD2 1 ATOM 187 C CE1 . PHE A 1 25 ? 23.353 146.601 3.919 1.00 227.22 ? 24 PHE A CE1 1 ATOM 188 C CE2 . PHE A 1 25 ? 21.572 144.992 4.124 1.00 227.22 ? 24 PHE A CE2 1 ATOM 189 C CZ . PHE A 1 25 ? 22.854 145.317 3.701 1.00 227.22 ? 24 PHE A CZ 1 ATOM 190 N N . GLU A 1 26 ? 19.262 149.259 8.667 1.00 227.22 ? 25 GLU A N 1 ATOM 191 C CA . GLU A 1 26 ? 18.210 150.078 9.268 1.00 227.22 ? 25 GLU A CA 1 ATOM 192 C C . GLU A 1 26 ? 18.484 150.565 10.701 1.00 227.22 ? 25 GLU A C 1 ATOM 193 O O . GLU A 1 26 ? 18.224 151.728 11.018 1.00 227.22 ? 25 GLU A O 1 ATOM 194 C CB . GLU A 1 26 ? 16.826 149.403 9.143 1.00 227.22 ? 25 GLU A CB 1 ATOM 195 C CG . GLU A 1 26 ? 16.713 147.976 9.692 1.00 227.22 ? 25 GLU A CG 1 ATOM 196 C CD . GLU A 1 26 ? 15.378 147.296 9.369 1.00 227.22 ? 25 GLU A CD 1 ATOM 197 O OE1 . GLU A 1 26 ? 15.180 146.134 9.795 1.00 227.22 ? 25 GLU A OE1 1 ATOM 198 O OE2 . GLU A 1 26 ? 14.526 147.913 8.691 1.00 227.22 ? 25 GLU A OE2 1 ATOM 199 N N . ALA A 1 27 ? 19.031 149.701 11.552 1.00 227.22 ? 26 ALA A N 1 ATOM 200 C CA . ALA A 1 27 ? 19.095 150.007 12.979 1.00 227.22 ? 26 ALA A CA 1 ATOM 201 C C . ALA A 1 27 ? 20.415 149.608 13.643 1.00 227.22 ? 26 ALA A C 1 ATOM 202 O O . ALA A 1 27 ? 21.169 148.809 13.072 1.00 227.22 ? 26 ALA A O 1 ATOM 203 C CB . ALA A 1 27 ? 17.912 149.358 13.698 1.00 227.22 ? 26 ALA A CB 1 ATOM 204 N N . PRO A 1 28 ? 20.697 150.164 14.854 1.00 227.22 ? 27 PRO A N 1 ATOM 205 C CA . PRO A 1 28 ? 21.918 149.822 15.599 1.00 227.22 ? 27 PRO A CA 1 ATOM 206 C C . PRO A 1 28 ? 21.881 148.406 16.178 1.00 227.22 ? 27 PRO A C 1 ATOM 207 O O . PRO A 1 28 ? 20.964 148.048 16.933 1.00 227.22 ? 27 PRO A O 1 ATOM 208 C CB . PRO A 1 28 ? 21.968 150.874 16.725 1.00 227.22 ? 27 PRO A CB 1 ATOM 209 C CG . PRO A 1 28 ? 20.914 151.888 16.397 1.00 227.22 ? 27 PRO A CG 1 ATOM 210 C CD . PRO A 1 28 ? 19.890 151.158 15.590 1.00 227.22 ? 27 PRO A CD 1 ATOM 211 N N . GLN A 1 29 ? 22.888 147.619 15.815 1.00 227.22 ? 28 GLN A N 1 ATOM 212 C CA . GLN A 1 29 ? 22.984 146.228 16.232 1.00 227.22 ? 28 GLN A CA 1 ATOM 213 C C . GLN A 1 29 ? 23.597 146.103 17.627 1.00 227.22 ? 28 GLN A C 1 ATOM 214 O O . GLN A 1 29 ? 24.154 145.062 17.976 1.00 227.22 ? 28 GLN A O 1 ATOM 215 C CB . GLN A 1 29 ? 23.808 145.436 15.215 1.00 227.22 ? 28 GLN A CB 1 ATOM 216 C CG . GLN A 1 29 ? 23.453 145.705 13.762 1.00 227.22 ? 28 GLN A CG 1 ATOM 217 C CD . GLN A 1 29 ? 22.065 145.229 13.396 1.00 227.22 ? 28 GLN A CD 1 ATOM 218 O OE1 . GLN A 1 29 ? 21.738 144.057 13.554 1.00 227.22 ? 28 GLN A OE1 1 ATOM 219 N NE2 . GLN A 1 29 ? 21.242 146.140 12.895 1.00 227.22 ? 28 GLN A NE2 1 ATOM 220 N N . TYR A 1 30 ? 23.479 147.162 18.427 1.00 227.22 ? 29 TYR A N 1 ATOM 221 C CA . TYR A 1 30 ? 24.043 147.199 19.777 1.00 227.22 ? 29 TYR A CA 1 ATOM 222 C C . TYR A 1 30 ? 23.695 145.951 20.597 1.00 227.22 ? 29 TYR A C 1 ATOM 223 O O . TYR A 1 30 ? 24.463 145.549 21.473 1.00 227.22 ? 29 TYR A O 1 ATOM 224 C CB . TYR A 1 30 ? 23.606 148.476 20.513 1.00 227.22 ? 29 TYR A CB 1 ATOM 225 C CG . TYR A 1 30 ? 24.427 149.729 20.200 1.00 227.22 ? 29 TYR A CG 1 ATOM 226 C CD1 . TYR A 1 30 ? 25.818 149.671 20.073 1.00 227.22 ? 29 TYR A CD1 1 ATOM 227 C CD2 . TYR A 1 30 ? 23.814 150.982 20.072 1.00 227.22 ? 29 TYR A CD2 1 ATOM 228 C CE1 . TYR A 1 30 ? 26.578 150.824 19.800 1.00 227.22 ? 29 TYR A CE1 1 ATOM 229 C CE2 . TYR A 1 30 ? 24.569 152.142 19.800 1.00 227.22 ? 29 TYR A CE2 1 ATOM 230 C CZ . TYR A 1 30 ? 25.948 152.050 19.668 1.00 227.22 ? 29 TYR A CZ 1 ATOM 231 O OH . TYR A 1 30 ? 26.699 153.175 19.405 1.00 227.22 ? 29 TYR A OH 1 ATOM 232 N N . TYR A 1 31 ? 22.553 145.337 20.279 1.00 227.22 ? 30 TYR A N 1 ATOM 233 C CA . TYR A 1 31 ? 22.085 144.111 20.933 1.00 227.22 ? 30 TYR A CA 1 ATOM 234 C C . TYR A 1 31 ? 22.977 142.895 20.677 1.00 227.22 ? 30 TYR A C 1 ATOM 235 O O . TYR A 1 31 ? 22.892 141.900 21.395 1.00 227.22 ? 30 TYR A O 1 ATOM 236 C CB . TYR A 1 31 ? 20.651 143.793 20.494 1.00 227.22 ? 30 TYR A CB 1 ATOM 237 C CG . TYR A 1 31 ? 20.493 143.547 19.003 1.00 227.22 ? 30 TYR A CG 1 ATOM 238 C CD1 . TYR A 1 31 ? 20.661 142.267 18.462 1.00 227.22 ? 30 TYR A CD1 1 ATOM 239 C CD2 . TYR A 1 31 ? 20.167 144.591 18.131 1.00 227.22 ? 30 TYR A CD2 1 ATOM 240 C CE1 . TYR A 1 31 ? 20.517 142.038 17.092 1.00 227.22 ? 30 TYR A CE1 1 ATOM 241 C CE2 . TYR A 1 31 ? 20.015 144.366 16.765 1.00 227.22 ? 30 TYR A CE2 1 ATOM 242 C CZ . TYR A 1 31 ? 20.195 143.092 16.257 1.00 227.22 ? 30 TYR A CZ 1 ATOM 243 O OH . TYR A 1 31 ? 20.045 142.871 14.915 1.00 227.22 ? 30 TYR A OH 1 ATOM 244 N N . LEU A 1 32 ? 23.816 142.978 19.647 1.00 227.22 ? 31 LEU A N 1 ATOM 245 C CA . LEU A 1 32 ? 24.694 141.871 19.254 1.00 227.22 ? 31 LEU A CA 1 ATOM 246 C C . LEU A 1 32 ? 25.846 141.655 20.215 1.00 227.22 ? 31 LEU A C 1 ATOM 247 O O . LEU A 1 32 ? 26.462 140.586 20.217 1.00 227.22 ? 31 LEU A O 1 ATOM 248 C CB . LEU A 1 32 ? 25.251 142.086 17.843 1.00 227.22 ? 31 LEU A CB 1 ATOM 249 C CG . LEU A 1 32 ? 24.380 141.653 16.661 1.00 227.22 ? 31 LEU A CG 1 ATOM 250 C CD1 . LEU A 1 32 ? 24.905 142.251 15.372 1.00 227.22 ? 31 LEU A CD1 1 ATOM 251 C CD2 . LEU A 1 32 ? 24.333 140.136 16.564 1.00 227.22 ? 31 LEU A CD2 1 ATOM 252 N N . ALA A 1 33 ? 26.139 142.685 21.010 1.00 227.22 ? 32 ALA A N 1 ATOM 253 C CA . ALA A 1 33 ? 27.168 142.623 22.050 1.00 227.22 ? 32 ALA A CA 1 ATOM 254 C C . ALA A 1 33 ? 27.111 143.848 22.968 1.00 227.22 ? 32 ALA A C 1 ATOM 255 O O . ALA A 1 33 ? 26.069 144.136 23.569 1.00 227.22 ? 32 ALA A O 1 ATOM 256 C CB . ALA A 1 33 ? 28.563 142.462 21.426 1.00 227.22 ? 32 ALA A CB 1 ATOM 257 N N . GLU A 1 34 ? 28.233 144.562 23.064 1.00 227.22 ? 33 GLU A N 1 ATOM 258 C CA . GLU A 1 34 ? 28.365 145.684 23.983 1.00 227.22 ? 33 GLU A CA 1 ATOM 259 C C . GLU A 1 34 ? 28.861 146.940 23.256 1.00 227.22 ? 33 GLU A C 1 ATOM 260 O O . GLU A 1 34 ? 29.776 146.855 22.435 1.00 227.22 ? 33 GLU A O 1 ATOM 261 C CB . GLU A 1 34 ? 29.339 145.332 25.125 1.00 227.22 ? 33 GLU A CB 1 ATOM 262 C CG . GLU A 1 34 ? 29.051 144.036 25.928 1.00 227.22 ? 33 GLU A CG 1 ATOM 263 C CD . GLU A 1 34 ? 28.404 144.274 27.298 1.00 227.22 ? 33 GLU A CD 1 ATOM 264 O OE1 . GLU A 1 34 ? 28.589 145.366 27.887 1.00 227.22 ? 33 GLU A OE1 1 ATOM 265 O OE2 . GLU A 1 34 ? 27.719 143.349 27.790 1.00 227.22 ? 33 GLU A OE2 1 ATOM 266 N N . PRO A 1 35 ? 28.246 148.107 23.551 1.00 227.22 ? 34 PRO A N 1 ATOM 267 C CA . PRO A 1 35 ? 28.696 149.427 23.088 1.00 227.22 ? 34 PRO A CA 1 ATOM 268 C C . PRO A 1 35 ? 30.220 149.633 23.089 1.00 227.22 ? 34 PRO A C 1 ATOM 269 O O . PRO A 1 35 ? 30.780 150.012 22.059 1.00 227.22 ? 34 PRO A O 1 ATOM 270 C CB . PRO A 1 35 ? 28.023 150.390 24.073 1.00 227.22 ? 34 PRO A CB 1 ATOM 271 C CG . PRO A 1 35 ? 26.757 149.703 24.448 1.00 227.22 ? 34 PRO A CG 1 ATOM 272 C CD . PRO A 1 35 ? 27.003 148.209 24.344 1.00 227.22 ? 34 PRO A CD 1 ATOM 273 N N . TRP A 1 36 ? 30.877 149.376 24.223 1.00 227.22 ? 35 TRP A N 1 ATOM 274 C CA . TRP A 1 36 ? 32.331 149.568 24.356 1.00 227.22 ? 35 TRP A CA 1 ATOM 275 C C . TRP A 1 36 ? 33.121 148.759 23.327 1.00 227.22 ? 35 TRP A C 1 ATOM 276 O O . TRP A 1 36 ? 34.218 149.152 22.929 1.00 227.22 ? 35 TRP A O 1 ATOM 277 C CB . TRP A 1 36 ? 32.814 149.237 25.782 1.00 227.22 ? 35 TRP A CB 1 ATOM 278 C CG . TRP A 1 36 ? 32.809 147.764 26.124 1.00 227.22 ? 35 TRP A CG 1 ATOM 279 C CD1 . TRP A 1 36 ? 31.719 146.995 26.401 1.00 227.22 ? 35 TRP A CD1 1 ATOM 280 C CD2 . TRP A 1 36 ? 33.949 146.894 26.229 1.00 227.22 ? 35 TRP A CD2 1 ATOM 281 N NE1 . TRP A 1 36 ? 32.101 145.701 26.661 1.00 227.22 ? 35 TRP A NE1 1 ATOM 282 C CE2 . TRP A 1 36 ? 33.464 145.610 26.563 1.00 227.22 ? 35 TRP A CE2 1 ATOM 283 C CE3 . TRP A 1 36 ? 35.330 147.073 26.071 1.00 227.22 ? 35 TRP A CE3 1 ATOM 284 C CZ2 . TRP A 1 36 ? 34.311 144.509 26.745 1.00 227.22 ? 35 TRP A CZ2 1 ATOM 285 C CZ3 . TRP A 1 36 ? 36.174 145.975 26.251 1.00 227.22 ? 35 TRP A CZ3 1 ATOM 286 C CH2 . TRP A 1 36 ? 35.658 144.711 26.585 1.00 227.22 ? 35 TRP A CH2 1 ATOM 287 N N . GLN A 1 37 ? 32.551 147.632 22.908 1.00 227.22 ? 36 GLN A N 1 ATOM 288 C CA . GLN A 1 37 ? 33.161 146.787 21.895 1.00 227.22 ? 36 GLN A CA 1 ATOM 289 C C . GLN A 1 37 ? 33.058 147.433 20.515 1.00 227.22 ? 36 GLN A C 1 ATOM 290 O O . GLN A 1 37 ? 33.936 147.232 19.682 1.00 227.22 ? 36 GLN A O 1 ATOM 291 C CB . GLN A 1 37 ? 32.539 145.384 21.902 1.00 227.22 ? 36 GLN A CB 1 ATOM 292 C CG . GLN A 1 37 ? 33.022 144.490 23.054 1.00 227.22 ? 36 GLN A CG 1 ATOM 293 C CD . GLN A 1 37 ? 32.084 143.319 23.375 1.00 227.22 ? 36 GLN A CD 1 ATOM 294 O OE1 . GLN A 1 37 ? 30.903 143.330 23.027 1.00 227.22 ? 36 GLN A OE1 1 ATOM 295 N NE2 . GLN A 1 37 ? 32.617 142.310 24.060 1.00 227.22 ? 36 GLN A NE2 1 ATOM 296 N N . PHE A 1 38 ? 32.005 148.218 20.275 1.00 227.22 ? 37 PHE A N 1 ATOM 297 C CA . PHE A 1 38 ? 31.834 148.882 18.975 1.00 227.22 ? 37 PHE A CA 1 ATOM 298 C C . PHE A 1 38 ? 32.778 150.053 18.780 1.00 227.22 ? 37 PHE A C 1 ATOM 299 O O . PHE A 1 38 ? 33.569 150.058 17.837 1.00 227.22 ? 37 PHE A O 1 ATOM 300 C CB . PHE A 1 38 ? 30.380 149.285 18.718 1.00 227.22 ? 37 PHE A CB 1 ATOM 301 C CG . PHE A 1 38 ? 29.508 148.138 18.297 1.00 227.22 ? 37 PHE A CG 1 ATOM 302 C CD1 . PHE A 1 38 ? 29.945 147.231 17.336 1.00 227.22 ? 37 PHE A CD1 1 ATOM 303 C CD2 . PHE A 1 38 ? 28.251 147.960 18.860 1.00 227.22 ? 37 PHE A CD2 1 ATOM 304 C CE1 . PHE A 1 38 ? 29.143 146.167 16.948 1.00 227.22 ? 37 PHE A CE1 1 ATOM 305 C CE2 . PHE A 1 38 ? 27.436 146.898 18.477 1.00 227.22 ? 37 PHE A CE2 1 ATOM 306 C CZ . PHE A 1 38 ? 27.885 146.000 17.521 1.00 227.22 ? 37 PHE A CZ 1 ATOM 307 N N . SER A 1 39 ? 32.707 151.035 19.675 1.00 227.22 ? 38 SER A N 1 ATOM 308 C CA . SER A 1 39 ? 33.643 152.159 19.647 1.00 227.22 ? 38 SER A CA 1 ATOM 309 C C . SER A 1 39 ? 35.069 151.709 20.020 1.00 227.22 ? 38 SER A C 1 ATOM 310 O O . SER A 1 39 ? 35.976 152.532 20.193 1.00 227.22 ? 38 SER A O 1 ATOM 311 C CB . SER A 1 39 ? 33.141 153.307 20.531 1.00 227.22 ? 38 SER A CB 1 ATOM 312 O OG . SER A 1 39 ? 31.848 153.734 20.123 1.00 227.22 ? 38 SER A OG 1 ATOM 313 N N . MET A 1 40 ? 35.241 150.391 20.134 1.00 227.22 ? 39 MET A N 1 ATOM 314 C CA . MET A 1 40 ? 36.549 149.758 20.260 1.00 227.22 ? 39 MET A CA 1 ATOM 315 C C . MET A 1 40 ? 37.126 149.533 18.863 1.00 227.22 ? 39 MET A C 1 ATOM 316 O O . MET A 1 40 ? 38.322 149.733 18.632 1.00 227.22 ? 39 MET A O 1 ATOM 317 C CB . MET A 1 40 ? 36.419 148.415 20.986 1.00 227.22 ? 39 MET A CB 1 ATOM 318 C CG . MET A 1 40 ? 37.694 147.902 21.631 1.00 227.22 ? 39 MET A CG 1 ATOM 319 S SD . MET A 1 40 ? 37.759 148.205 23.409 1.00 227.22 ? 39 MET A SD 1 ATOM 320 C CE . MET A 1 40 ? 38.027 149.983 23.487 1.00 227.22 ? 39 MET A CE 1 ATOM 321 N N . LEU A 1 41 ? 36.256 149.118 17.942 1.00 227.22 ? 40 LEU A N 1 ATOM 322 C CA . LEU A 1 41 ? 36.635 148.814 16.565 1.00 227.22 ? 40 LEU A CA 1 ATOM 323 C C . LEU A 1 41 ? 36.811 150.083 15.742 1.00 227.22 ? 40 LEU A C 1 ATOM 324 O O . LEU A 1 41 ? 37.733 150.180 14.935 1.00 227.22 ? 40 LEU A O 1 ATOM 325 C CB . LEU A 1 41 ? 35.594 147.900 15.918 1.00 227.22 ? 40 LEU A CB 1 ATOM 326 C CG . LEU A 1 41 ? 35.339 146.563 16.622 1.00 227.22 ? 40 LEU A CG 1 ATOM 327 C CD1 . LEU A 1 41 ? 34.000 145.987 16.200 1.00 227.22 ? 40 LEU A CD1 1 ATOM 328 C CD2 . LEU A 1 41 ? 36.468 145.565 16.374 1.00 227.22 ? 40 LEU A CD2 1 ATOM 329 N N . ALA A 1 42 ? 35.922 151.051 15.954 1.00 227.22 ? 41 ALA A N 1 ATOM 330 C CA . ALA A 1 42 ? 36.040 152.370 15.338 1.00 227.22 ? 41 ALA A CA 1 ATOM 331 C C . ALA A 1 42 ? 37.347 153.059 15.731 1.00 227.22 ? 41 ALA A C 1 ATOM 332 O O . ALA A 1 42 ? 37.933 153.793 14.933 1.00 227.22 ? 41 ALA A O 1 ATOM 333 C CB . ALA A 1 42 ? 34.855 153.232 15.714 1.00 227.22 ? 41 ALA A CB 1 ATOM 334 N N . ALA A 1 43 ? 37.796 152.811 16.960 1.00 227.22 ? 42 ALA A N 1 ATOM 335 C CA . ALA A 1 43 ? 39.062 153.342 17.466 1.00 227.22 ? 42 ALA A CA 1 ATOM 336 C C . ALA A 1 43 ? 40.252 152.597 16.864 1.00 227.22 ? 42 ALA A C 1 ATOM 337 O O . ALA A 1 43 ? 41.381 153.097 16.872 1.00 227.22 ? 42 ALA A O 1 ATOM 338 C CB . ALA A 1 43 ? 39.093 153.263 18.982 1.00 227.22 ? 42 ALA A CB 1 ATOM 339 N N . TYR A 1 44 ? 39.978 151.402 16.344 1.00 227.22 ? 43 TYR A N 1 ATOM 340 C CA . TYR A 1 44 ? 40.970 150.573 15.671 1.00 227.22 ? 43 TYR A CA 1 ATOM 341 C C . TYR A 1 44 ? 41.003 150.870 14.178 1.00 227.22 ? 43 TYR A C 1 ATOM 342 O O . TYR A 1 44 ? 42.047 150.721 13.542 1.00 227.22 ? 43 TYR A O 1 ATOM 343 C CB . TYR A 1 44 ? 40.657 149.099 15.917 1.00 227.22 ? 43 TYR A CB 1 ATOM 344 C CG . TYR A 1 44 ? 41.480 148.109 15.123 1.00 227.22 ? 43 TYR A CG 1 ATOM 345 C CD1 . TYR A 1 44 ? 42.807 147.839 15.460 1.00 227.22 ? 43 TYR A CD1 1 ATOM 346 C CD2 . TYR A 1 44 ? 40.917 147.415 14.055 1.00 227.22 ? 43 TYR A CD2 1 ATOM 347 C CE1 . TYR A 1 44 ? 43.559 146.914 14.738 1.00 227.22 ? 43 TYR A CE1 1 ATOM 348 C CE2 . TYR A 1 44 ? 41.655 146.491 13.331 1.00 227.22 ? 43 TYR A CE2 1 ATOM 349 C CZ . TYR A 1 44 ? 42.975 146.239 13.676 1.00 227.22 ? 43 TYR A CZ 1 ATOM 350 O OH . TYR A 1 44 ? 43.710 145.318 12.955 1.00 227.22 ? 43 TYR A OH 1 ATOM 351 N N . MET A 1 45 ? 39.861 151.281 13.624 1.00 227.22 ? 44 MET A N 1 ATOM 352 C CA . MET A 1 45 ? 39.789 151.697 12.220 1.00 227.22 ? 44 MET A CA 1 ATOM 353 C C . MET A 1 45 ? 40.578 152.972 11.984 1.00 227.22 ? 44 MET A C 1 ATOM 354 O O . MET A 1 45 ? 41.312 153.083 11.001 1.00 227.22 ? 44 MET A O 1 ATOM 355 C CB . MET A 1 45 ? 38.339 151.883 11.740 1.00 227.22 ? 44 MET A CB 1 ATOM 356 C CG . MET A 1 45 ? 37.616 150.597 11.346 1.00 227.22 ? 44 MET A CG 1 ATOM 357 S SD . MET A 1 45 ? 38.715 149.246 10.861 1.00 227.22 ? 44 MET A SD 1 ATOM 358 C CE . MET A 1 45 ? 39.549 149.942 9.441 1.00 227.22 ? 44 MET A CE 1 ATOM 359 N N . PHE A 1 46 ? 40.420 153.923 12.899 1.00 227.22 ? 45 PHE A N 1 ATOM 360 C CA . PHE A 1 46 ? 41.112 155.195 12.824 1.00 227.22 ? 45 PHE A CA 1 ATOM 361 C C . PHE A 1 46 ? 42.612 154.976 12.892 1.00 227.22 ? 45 PHE A C 1 ATOM 362 O O . PHE A 1 46 ? 43.342 155.467 12.046 1.00 227.22 ? 45 PHE A O 1 ATOM 363 C CB . PHE A 1 46 ? 40.645 156.107 13.954 1.00 227.22 ? 45 PHE A CB 1 ATOM 364 C CG . PHE A 1 46 ? 40.986 157.557 13.754 1.00 227.22 ? 45 PHE A CG 1 ATOM 365 C CD1 . PHE A 1 46 ? 42.113 158.110 14.358 1.00 227.22 ? 45 PHE A CD1 1 ATOM 366 C CD2 . PHE A 1 46 ? 40.168 158.378 12.985 1.00 227.22 ? 45 PHE A CD2 1 ATOM 367 C CE1 . PHE A 1 46 ? 42.426 159.456 14.190 1.00 227.22 ? 45 PHE A CE1 1 ATOM 368 C CE2 . PHE A 1 46 ? 40.475 159.721 12.807 1.00 227.22 ? 45 PHE A CE2 1 ATOM 369 C CZ . PHE A 1 46 ? 41.605 160.261 13.410 1.00 227.22 ? 45 PHE A CZ 1 ATOM 370 N N . LEU A 1 47 ? 43.060 154.211 13.881 1.00 227.22 ? 46 LEU A N 1 ATOM 371 C CA . LEU A 1 47 ? 44.479 153.913 14.044 1.00 227.22 ? 46 LEU A CA 1 ATOM 372 C C . LEU A 1 47 ? 45.082 153.259 12.810 1.00 227.22 ? 46 LEU A C 1 ATOM 373 O O . LEU A 1 47 ? 46.216 153.566 12.438 1.00 227.22 ? 46 LEU A O 1 ATOM 374 C CB . LEU A 1 47 ? 44.708 153.035 15.274 1.00 227.22 ? 46 LEU A CB 1 ATOM 375 C CG . LEU A 1 47 ? 44.763 153.776 16.612 1.00 227.22 ? 46 LEU A CG 1 ATOM 376 C CD1 . LEU A 1 47 ? 44.537 152.822 17.765 1.00 227.22 ? 46 LEU A CD1 1 ATOM 377 C CD2 . LEU A 1 47 ? 46.084 154.524 16.783 1.00 227.22 ? 46 LEU A CD2 1 ATOM 378 N N . LEU A 1 48 ? 44.321 152.359 12.185 1.00 227.22 ? 47 LEU A N 1 ATOM 379 C CA . LEU A 1 48 ? 44.717 151.736 10.918 1.00 227.22 ? 47 LEU A CA 1 ATOM 380 C C . LEU A 1 48 ? 44.852 152.792 9.838 1.00 227.22 ? 47 LEU A C 1 ATOM 381 O O . LEU A 1 48 ? 45.934 152.982 9.283 1.00 227.22 ? 47 LEU A O 1 ATOM 382 C CB . LEU A 1 48 ? 43.711 150.668 10.476 1.00 227.22 ? 47 LEU A CB 1 ATOM 383 C CG . LEU A 1 48 ? 44.029 149.196 10.744 1.00 227.22 ? 47 LEU A CG 1 ATOM 384 C CD1 . LEU A 1 48 ? 42.844 148.340 10.324 1.00 227.22 ? 47 LEU A CD1 1 ATOM 385 C CD2 . LEU A 1 48 ? 45.307 148.746 10.034 1.00 227.22 ? 47 LEU A CD2 1 ATOM 386 N N . ILE A 1 49 ? 43.750 153.481 9.555 1.00 227.22 ? 48 ILE A N 1 ATOM 387 C CA . ILE A 1 49 ? 43.771 154.637 8.680 1.00 227.22 ? 48 ILE A CA 1 ATOM 388 C C . ILE A 1 49 ? 44.985 155.506 9.020 1.00 227.22 ? 48 ILE A C 1 ATOM 389 O O . ILE A 1 49 ? 45.628 156.047 8.127 1.00 227.22 ? 48 ILE A O 1 ATOM 390 C CB . ILE A 1 49 ? 42.455 155.437 8.798 1.00 227.22 ? 48 ILE A CB 1 ATOM 391 C CG1 . ILE A 1 49 ? 41.296 154.613 8.240 1.00 227.22 ? 48 ILE A CG1 1 ATOM 392 C CG2 . ILE A 1 49 ? 42.546 156.756 8.059 1.00 227.22 ? 48 ILE A CG2 1 ATOM 393 C CD1 . ILE A 1 49 ? 39.924 155.108 8.637 1.00 227.22 ? 48 ILE A CD1 1 ATOM 394 N N . MET A 1 50 ? 45.335 155.575 10.305 1.00 227.22 ? 49 MET A N 1 ATOM 395 C CA . MET A 1 50 ? 46.312 156.558 10.794 1.00 227.22 ? 49 MET A CA 1 ATOM 396 C C . MET A 1 50 ? 47.786 156.258 10.681 1.00 227.22 ? 49 MET A C 1 ATOM 397 O O . MET A 1 50 ? 48.606 157.174 10.623 1.00 227.22 ? 49 MET A O 1 ATOM 398 C CB . MET A 1 50 ? 45.986 157.013 12.213 1.00 227.22 ? 49 MET A CB 1 ATOM 399 C CG . MET A 1 50 ? 44.980 158.129 12.201 1.00 227.22 ? 49 MET A CG 1 ATOM 400 S SD . MET A 1 50 ? 44.595 158.680 10.513 1.00 227.22 ? 49 MET A SD 1 ATOM 401 C CE . MET A 1 50 ? 46.205 159.116 9.817 1.00 227.22 ? 49 MET A CE 1 ATOM 402 N N . LEU A 1 51 ? 48.126 154.985 10.694 1.00 227.22 ? 50 LEU A N 1 ATOM 403 C CA . LEU A 1 51 ? 49.482 154.603 10.393 1.00 227.22 ? 50 LEU A CA 1 ATOM 404 C C . LEU A 1 51 ? 49.548 154.270 8.913 1.00 227.22 ? 50 LEU A C 1 ATOM 405 O O . LEU A 1 51 ? 50.597 154.409 8.304 1.00 227.22 ? 50 LEU A O 1 ATOM 406 C CB . LEU A 1 51 ? 49.941 153.438 11.276 1.00 227.22 ? 50 LEU A CB 1 ATOM 407 C CG . LEU A 1 51 ? 50.187 153.799 12.753 1.00 227.22 ? 50 LEU A CG 1 ATOM 408 C CD1 . LEU A 1 51 ? 50.127 152.562 13.637 1.00 227.22 ? 50 LEU A CD1 1 ATOM 409 C CD2 . LEU A 1 51 ? 51.507 154.542 12.961 1.00 227.22 ? 50 LEU A CD2 1 ATOM 410 N N . GLY A 1 52 ? 48.409 153.878 8.342 1.00 227.22 ? 51 GLY A N 1 ATOM 411 C CA . GLY A 1 52 ? 48.308 153.525 6.924 1.00 227.22 ? 51 GLY A CA 1 ATOM 412 C C . GLY A 1 52 ? 48.434 154.706 5.984 1.00 227.22 ? 51 GLY A C 1 ATOM 413 O O . GLY A 1 52 ? 49.392 154.785 5.212 1.00 227.22 ? 51 GLY A O 1 ATOM 414 N N . PHE A 1 53 ? 47.471 155.624 6.053 1.00 227.22 ? 52 PHE A N 1 ATOM 415 C CA . PHE A 1 53 ? 47.500 156.838 5.236 1.00 227.22 ? 52 PHE A CA 1 ATOM 416 C C . PHE A 1 53 ? 48.915 157.423 5.095 1.00 227.22 ? 52 PHE A C 1 ATOM 417 O O . PHE A 1 53 ? 49.411 157.534 3.978 1.00 227.22 ? 52 PHE A O 1 ATOM 418 C CB . PHE A 1 53 ? 46.478 157.881 5.734 1.00 227.22 ? 52 PHE A CB 1 ATOM 419 C CG . PHE A 1 53 ? 46.869 159.314 5.456 1.00 227.22 ? 52 PHE A CG 1 ATOM 420 C CD1 . PHE A 1 53 ? 46.803 159.834 4.167 1.00 227.22 ? 52 PHE A CD1 1 ATOM 421 C CD2 . PHE A 1 53 ? 47.294 160.146 6.491 1.00 227.22 ? 52 PHE A CD2 1 ATOM 422 C CE1 . PHE A 1 53 ? 47.169 161.159 3.915 1.00 227.22 ? 52 PHE A CE1 1 ATOM 423 C CE2 . PHE A 1 53 ? 47.662 161.470 6.252 1.00 227.22 ? 52 PHE A CE2 1 ATOM 424 C CZ . PHE A 1 53 ? 47.596 161.979 4.965 1.00 227.22 ? 52 PHE A CZ 1 ATOM 425 N N . PRO A 1 54 ? 49.583 157.765 6.217 1.00 227.22 ? 53 PRO A N 1 ATOM 426 C CA . PRO A 1 54 ? 50.830 158.504 6.030 1.00 227.22 ? 53 PRO A CA 1 ATOM 427 C C . PRO A 1 54 ? 52.028 157.647 5.616 1.00 227.22 ? 53 PRO A C 1 ATOM 428 O O . PRO A 1 54 ? 52.958 158.177 5.017 1.00 227.22 ? 53 PRO A O 1 ATOM 429 C CB . PRO A 1 54 ? 51.062 159.159 7.395 1.00 227.22 ? 53 PRO A CB 1 ATOM 430 C CG . PRO A 1 54 ? 50.377 158.280 8.367 1.00 227.22 ? 53 PRO A CG 1 ATOM 431 C CD . PRO A 1 54 ? 49.293 157.522 7.645 1.00 227.22 ? 53 PRO A CD 1 ATOM 432 N N . ILE A 1 55 ? 52.015 156.352 5.924 1.00 227.22 ? 54 ILE A N 1 ATOM 433 C CA . ILE A 1 55 ? 53.129 155.487 5.525 1.00 227.22 ? 54 ILE A CA 1 ATOM 434 C C . ILE A 1 55 ? 52.987 154.977 4.098 1.00 227.22 ? 54 ILE A C 1 ATOM 435 O O . ILE A 1 55 ? 53.988 154.641 3.477 1.00 227.22 ? 54 ILE A O 1 ATOM 436 C CB . ILE A 1 55 ? 53.373 154.273 6.471 1.00 227.22 ? 54 ILE A CB 1 ATOM 437 C CG1 . ILE A 1 55 ? 52.170 153.317 6.458 1.00 227.22 ? 54 ILE A CG1 1 ATOM 438 C CG2 . ILE A 1 55 ? 53.780 154.737 7.883 1.00 227.22 ? 54 ILE A CG2 1 ATOM 439 C CD1 . ILE A 1 55 ? 52.523 151.878 6.723 1.00 227.22 ? 54 ILE A CD1 1 ATOM 440 N N . ASN A 1 56 ? 51.755 154.903 3.594 1.00 227.22 ? 55 ASN A N 1 ATOM 441 C CA . ASN A 1 56 ? 51.503 154.461 2.217 1.00 227.22 ? 55 ASN A CA 1 ATOM 442 C C . ASN A 1 56 ? 51.695 155.569 1.191 1.00 227.22 ? 55 ASN A C 1 ATOM 443 O O . ASN A 1 56 ? 52.324 155.359 0.156 1.00 227.22 ? 55 ASN A O 1 ATOM 444 C CB . ASN A 1 56 ? 50.107 153.864 2.083 1.00 227.22 ? 55 ASN A CB 1 ATOM 445 C CG . ASN A 1 56 ? 50.052 152.421 2.498 1.00 227.22 ? 55 ASN A CG 1 ATOM 446 O OD1 . ASN A 1 56 ? 50.756 151.580 1.951 1.00 227.22 ? 55 ASN A OD1 1 ATOM 447 N ND2 . ASN A 1 56 ? 49.201 152.120 3.464 1.00 227.22 ? 55 ASN A ND2 1 ATOM 448 N N . PHE A 1 57 ? 51.133 156.741 1.481 1.00 227.22 ? 56 PHE A N 1 ATOM 449 C CA . PHE A 1 57 ? 51.391 157.953 0.706 1.00 227.22 ? 56 PHE A CA 1 ATOM 450 C C . PHE A 1 57 ? 52.884 158.255 0.734 1.00 227.22 ? 56 PHE A C 1 ATOM 451 O O . PHE A 1 57 ? 53.477 158.515 -0.304 1.00 227.22 ? 56 PHE A O 1 ATOM 452 C CB . PHE A 1 57 ? 50.588 159.131 1.276 1.00 227.22 ? 56 PHE A CB 1 ATOM 453 C CG . PHE A 1 57 ? 50.795 160.453 0.553 1.00 227.22 ? 56 PHE A CG 1 ATOM 454 C CD1 . PHE A 1 57 ? 49.716 161.108 -0.035 1.00 227.22 ? 56 PHE A CD1 1 ATOM 455 C CD2 . PHE A 1 57 ? 52.050 161.066 0.499 1.00 227.22 ? 56 PHE A CD2 1 ATOM 456 C CE1 . PHE A 1 57 ? 49.885 162.338 -0.685 1.00 227.22 ? 56 PHE A CE1 1 ATOM 457 C CE2 . PHE A 1 57 ? 52.227 162.290 -0.150 1.00 227.22 ? 56 PHE A CE2 1 ATOM 458 C CZ . PHE A 1 57 ? 51.144 162.927 -0.739 1.00 227.22 ? 56 PHE A CZ 1 ATOM 459 N N . LEU A 1 58 ? 53.484 158.207 1.924 1.00 227.22 ? 57 LEU A N 1 ATOM 460 C CA . LEU A 1 58 ? 54.918 158.440 2.073 1.00 227.22 ? 57 LEU A CA 1 ATOM 461 C C . LEU A 1 58 ? 55.721 157.406 1.284 1.00 227.22 ? 57 LEU A C 1 ATOM 462 O O . LEU A 1 58 ? 56.765 157.736 0.720 1.00 227.22 ? 57 LEU A O 1 ATOM 463 C CB . LEU A 1 58 ? 55.327 158.461 3.550 1.00 227.22 ? 57 LEU A CB 1 ATOM 464 C CG . LEU A 1 58 ? 56.597 159.189 4.022 1.00 227.22 ? 57 LEU A CG 1 ATOM 465 C CD1 . LEU A 1 58 ? 57.826 158.294 3.939 1.00 227.22 ? 57 LEU A CD1 1 ATOM 466 C CD2 . LEU A 1 58 ? 56.841 160.501 3.294 1.00 227.22 ? 57 LEU A CD2 1 ATOM 467 N N . THR A 1 59 ? 55.227 156.166 1.231 1.00 227.22 ? 58 THR A N 1 ATOM 468 C CA . THR A 1 59 ? 55.803 155.143 0.347 1.00 227.22 ? 58 THR A CA 1 ATOM 469 C C . THR A 1 59 ? 55.796 155.675 -1.081 1.00 227.22 ? 58 THR A C 1 ATOM 470 O O . THR A 1 59 ? 56.842 155.727 -1.731 1.00 227.22 ? 58 THR A O 1 ATOM 471 C CB . THR A 1 59 ? 55.036 153.789 0.405 1.00 227.22 ? 58 THR A CB 1 ATOM 472 O OG1 . THR A 1 59 ? 55.061 153.268 1.740 1.00 227.22 ? 58 THR A OG1 1 ATOM 473 C CG2 . THR A 1 59 ? 55.660 152.762 -0.542 1.00 227.22 ? 58 THR A CG2 1 ATOM 474 N N . LEU A 1 60 ? 54.614 156.083 -1.545 1.00 227.22 ? 59 LEU A N 1 ATOM 475 C CA . LEU A 1 60 ? 54.456 156.717 -2.849 1.00 227.22 ? 59 LEU A CA 1 ATOM 476 C C . LEU A 1 60 ? 55.353 157.959 -2.974 1.00 227.22 ? 59 LEU A C 1 ATOM 477 O O . LEU A 1 60 ? 56.120 158.070 -3.930 1.00 227.22 ? 59 LEU A O 1 ATOM 478 C CB . LEU A 1 60 ? 52.981 157.059 -3.100 1.00 227.22 ? 59 LEU A CB 1 ATOM 479 C CG . LEU A 1 60 ? 52.606 157.945 -4.288 1.00 227.22 ? 59 LEU A CG 1 ATOM 480 C CD1 . LEU A 1 60 ? 52.539 157.137 -5.574 1.00 227.22 ? 59 LEU A CD1 1 ATOM 481 C CD2 . LEU A 1 60 ? 51.283 158.645 -4.031 1.00 227.22 ? 59 LEU A CD2 1 ATOM 482 N N . TYR A 1 61 ? 55.273 158.855 -1.987 1.00 227.22 ? 60 TYR A N 1 ATOM 483 C CA . TYR A 1 61 ? 56.020 160.127 -1.956 1.00 227.22 ? 60 TYR A CA 1 ATOM 484 C C . TYR A 1 61 ? 57.524 159.931 -2.098 1.00 227.22 ? 60 TYR A C 1 ATOM 485 O O . TYR A 1 61 ? 58.200 160.760 -2.699 1.00 227.22 ? 60 TYR A O 1 ATOM 486 C CB . TYR A 1 61 ? 55.704 160.892 -0.656 1.00 227.22 ? 60 TYR A CB 1 ATOM 487 C CG . TYR A 1 61 ? 56.208 162.336 -0.531 1.00 227.22 ? 60 TYR A CG 1 ATOM 488 C CD1 . TYR A 1 61 ? 57.566 162.623 -0.351 1.00 227.22 ? 60 TYR A CD1 1 ATOM 489 C CD2 . TYR A 1 61 ? 55.311 163.410 -0.522 1.00 227.22 ? 60 TYR A CD2 1 ATOM 490 C CE1 . TYR A 1 61 ? 58.021 163.945 -0.211 1.00 227.22 ? 60 TYR A CE1 1 ATOM 491 C CE2 . TYR A 1 61 ? 55.756 164.733 -0.378 1.00 227.22 ? 60 TYR A CE2 1 ATOM 492 C CZ . TYR A 1 61 ? 57.111 164.991 -0.223 1.00 227.22 ? 60 TYR A CZ 1 ATOM 493 O OH . TYR A 1 61 ? 57.558 166.289 -0.082 1.00 227.22 ? 60 TYR A OH 1 ATOM 494 N N . VAL A 1 62 ? 58.048 158.844 -1.541 1.00 227.22 ? 61 VAL A N 1 ATOM 495 C CA . VAL A 1 62 ? 59.481 158.568 -1.636 1.00 227.22 ? 61 VAL A CA 1 ATOM 496 C C . VAL A 1 62 ? 59.863 158.055 -3.031 1.00 227.22 ? 61 VAL A C 1 ATOM 497 O O . VAL A 1 62 ? 60.829 158.545 -3.634 1.00 227.22 ? 61 VAL A O 1 ATOM 498 C CB . VAL A 1 62 ? 59.966 157.612 -0.513 1.00 227.22 ? 61 VAL A CB 1 ATOM 499 C CG1 . VAL A 1 62 ? 61.377 157.090 -0.789 1.00 227.22 ? 61 VAL A CG1 1 ATOM 500 C CG2 . VAL A 1 62 ? 59.926 158.330 0.822 1.00 227.22 ? 61 VAL A CG2 1 ATOM 501 N N . THR A 1 63 ? 59.096 157.088 -3.540 1.00 227.22 ? 62 THR A N 1 ATOM 502 C CA . THR A 1 63 ? 59.342 156.510 -4.865 1.00 227.22 ? 62 THR A CA 1 ATOM 503 C C . THR A 1 63 ? 59.161 157.576 -5.933 1.00 227.22 ? 62 THR A C 1 ATOM 504 O O . THR A 1 63 ? 59.924 157.629 -6.895 1.00 227.22 ? 62 THR A O 1 ATOM 505 C CB . THR A 1 63 ? 58.410 155.321 -5.180 1.00 227.22 ? 62 THR A CB 1 ATOM 506 O OG1 . THR A 1 63 ? 58.080 154.612 -3.978 1.00 227.22 ? 62 THR A OG1 1 ATOM 507 C CG2 . THR A 1 63 ? 59.080 154.367 -6.159 1.00 227.22 ? 62 THR A CG2 1 ATOM 508 N N . VAL A 1 64 ? 58.143 158.414 -5.748 1.00 227.22 ? 63 VAL A N 1 ATOM 509 C CA . VAL A 1 64 ? 57.946 159.622 -6.544 1.00 227.22 ? 63 VAL A CA 1 ATOM 510 C C . VAL A 1 64 ? 59.272 160.388 -6.718 1.00 227.22 ? 63 VAL A C 1 ATOM 511 O O . VAL A 1 64 ? 59.854 160.386 -7.809 1.00 227.22 ? 63 VAL A O 1 ATOM 512 C CB . VAL A 1 64 ? 56.801 160.518 -5.940 1.00 227.22 ? 63 VAL A CB 1 ATOM 513 C CG1 . VAL A 1 64 ? 56.913 161.986 -6.362 1.00 227.22 ? 63 VAL A CG1 1 ATOM 514 C CG2 . VAL A 1 64 ? 55.433 159.963 -6.310 1.00 227.22 ? 63 VAL A CG2 1 ATOM 515 N N . GLN A 1 65 ? 59.763 160.997 -5.637 1.00 227.22 ? 64 GLN A N 1 ATOM 516 C CA . GLN A 1 65 ? 60.937 161.879 -5.682 1.00 227.22 ? 64 GLN A CA 1 ATOM 517 C C . GLN A 1 65 ? 62.196 161.173 -6.189 1.00 227.22 ? 64 GLN A C 1 ATOM 518 O O . GLN A 1 65 ? 63.025 161.776 -6.877 1.00 227.22 ? 64 GLN A O 1 ATOM 519 C CB . GLN A 1 65 ? 61.199 162.496 -4.297 1.00 227.22 ? 64 GLN A CB 1 ATOM 520 C CG . GLN A 1 65 ? 62.277 163.584 -4.272 1.00 227.22 ? 64 GLN A CG 1 ATOM 521 C CD . GLN A 1 65 ? 62.757 163.923 -2.866 1.00 227.22 ? 64 GLN A CD 1 ATOM 522 O OE1 . GLN A 1 65 ? 62.076 164.623 -2.117 1.00 227.22 ? 64 GLN A OE1 1 ATOM 523 N NE2 . GLN A 1 65 ? 63.948 163.447 -2.514 1.00 227.22 ? 64 GLN A NE2 1 ATOM 524 N N . HIS A 1 66 ? 62.323 159.894 -5.862 1.00 227.22 ? 65 HIS A N 1 ATOM 525 C CA . HIS A 1 66 ? 63.576 159.187 -6.079 1.00 227.22 ? 65 HIS A CA 1 ATOM 526 C C . HIS A 1 66 ? 63.644 158.404 -7.387 1.00 227.22 ? 65 HIS A C 1 ATOM 527 O O . HIS A 1 66 ? 62.980 157.377 -7.558 1.00 227.22 ? 65 HIS A O 1 ATOM 528 C CB . HIS A 1 66 ? 63.919 158.339 -4.851 1.00 227.22 ? 65 HIS A CB 1 ATOM 529 C CG . HIS A 1 66 ? 64.356 159.160 -3.678 1.00 227.22 ? 65 HIS A CG 1 ATOM 530 N ND1 . HIS A 1 66 ? 65.653 159.167 -3.212 1.00 227.22 ? 65 HIS A ND1 1 ATOM 531 C CD2 . HIS A 1 66 ? 63.676 160.042 -2.907 1.00 227.22 ? 65 HIS A CD2 1 ATOM 532 C CE1 . HIS A 1 66 ? 65.747 159.998 -2.190 1.00 227.22 ? 65 HIS A CE1 1 ATOM 533 N NE2 . HIS A 1 66 ? 64.563 160.544 -1.986 1.00 227.22 ? 65 HIS A NE2 1 ATOM 534 N N . LYS A 1 67 ? 64.469 158.912 -8.301 1.00 227.22 ? 66 LYS A N 1 ATOM 535 C CA . LYS A 1 67 ? 64.585 158.359 -9.650 1.00 227.22 ? 66 LYS A CA 1 ATOM 536 C C . LYS A 1 67 ? 65.354 157.030 -9.713 1.00 227.22 ? 66 LYS A C 1 ATOM 537 O O . LYS A 1 67 ? 65.271 156.324 -10.724 1.00 227.22 ? 66 LYS A O 1 ATOM 538 C CB . LYS A 1 67 ? 65.199 159.380 -10.636 1.00 227.22 ? 66 LYS A CB 1 ATOM 539 C CG . LYS A 1 67 ? 64.539 160.780 -10.689 1.00 227.22 ? 66 LYS A CG 1 ATOM 540 C CD . LYS A 1 67 ? 63.003 160.757 -10.790 1.00 227.22 ? 66 LYS A CD 1 ATOM 541 C CE . LYS A 1 67 ? 62.507 160.445 -12.196 1.00 227.22 ? 66 LYS A CE 1 ATOM 542 N NZ . LYS A 1 67 ? 61.013 160.535 -12.253 1.00 227.22 ? 66 LYS A NZ 1 ATOM 543 N N . LYS A 1 68 ? 66.095 156.689 -8.654 1.00 227.22 ? 67 LYS A N 1 ATOM 544 C CA . LYS A 1 68 ? 66.839 155.417 -8.619 1.00 227.22 ? 67 LYS A CA 1 ATOM 545 C C . LYS A 1 68 ? 65.947 154.238 -8.201 1.00 227.22 ? 67 LYS A C 1 ATOM 546 O O . LYS A 1 68 ? 66.335 153.067 -8.319 1.00 227.22 ? 67 LYS A O 1 ATOM 547 C CB . LYS A 1 68 ? 68.104 155.519 -7.748 1.00 227.22 ? 67 LYS A CB 1 ATOM 548 C CG . LYS A 1 68 ? 67.924 155.198 -6.263 1.00 227.22 ? 67 LYS A CG 1 ATOM 549 C CD . LYS A 1 68 ? 69.195 155.511 -5.473 1.00 227.22 ? 67 LYS A CD 1 ATOM 550 C CE . LYS A 1 68 ? 69.080 155.067 -4.017 1.00 227.22 ? 67 LYS A CE 1 ATOM 551 N NZ . LYS A 1 68 ? 70.075 155.747 -3.139 1.00 227.22 ? 67 LYS A NZ 1 ATOM 552 N N . LEU A 1 69 ? 64.751 154.562 -7.721 1.00 227.22 ? 68 LEU A N 1 ATOM 553 C CA . LEU A 1 69 ? 63.750 153.560 -7.398 1.00 227.22 ? 68 LEU A CA 1 ATOM 554 C C . LEU A 1 69 ? 62.853 153.294 -8.609 1.00 227.22 ? 68 LEU A C 1 ATOM 555 O O . LEU A 1 69 ? 61.703 153.745 -8.651 1.00 227.22 ? 68 LEU A O 1 ATOM 556 C CB . LEU A 1 69 ? 62.928 153.994 -6.174 1.00 227.22 ? 68 LEU A CB 1 ATOM 557 C CG . LEU A 1 69 ? 63.315 153.510 -4.765 1.00 227.22 ? 68 LEU A CG 1 ATOM 558 C CD1 . LEU A 1 69 ? 64.677 154.010 -4.291 1.00 227.22 ? 68 LEU A CD1 1 ATOM 559 C CD2 . LEU A 1 69 ? 62.234 153.909 -3.781 1.00 227.22 ? 68 LEU A CD2 1 ATOM 560 N N . ARG A 1 70 ? 63.396 152.577 -9.596 1.00 227.22 ? 69 ARG A N 1 ATOM 561 C CA . ARG A 1 70 ? 62.655 152.197 -10.816 1.00 227.22 ? 69 ARG A CA 1 ATOM 562 C C . ARG A 1 70 ? 62.825 150.709 -11.152 1.00 227.22 ? 69 ARG A C 1 ATOM 563 O O . ARG A 1 70 ? 62.751 150.313 -12.318 1.00 227.22 ? 69 ARG A O 1 ATOM 564 C CB . ARG A 1 70 ? 63.070 153.062 -12.024 1.00 227.22 ? 69 ARG A CB 1 ATOM 565 C CG . ARG A 1 70 ? 62.722 154.552 -11.933 1.00 227.22 ? 69 ARG A CG 1 ATOM 566 C CD . ARG A 1 70 ? 61.215 154.803 -11.904 1.00 227.22 ? 69 ARG A CD 1 ATOM 567 N NE . ARG A 1 70 ? 60.884 156.217 -11.682 1.00 227.22 ? 69 ARG A NE 1 ATOM 568 C CZ . ARG A 1 70 ? 60.406 156.727 -10.541 1.00 227.22 ? 69 ARG A CZ 1 ATOM 569 N NH1 . ARG A 1 70 ? 60.189 155.949 -9.480 1.00 227.22 ? 69 ARG A NH1 1 ATOM 570 N NH2 . ARG A 1 70 ? 60.139 158.027 -10.464 1.00 227.22 ? 69 ARG A NH2 1 ATOM 571 N N . THR A 1 71 ? 63.038 149.897 -10.119 1.00 227.22 ? 70 THR A N 1 ATOM 572 C CA . THR A 1 71 ? 63.312 148.465 -10.273 1.00 227.22 ? 70 THR A CA 1 ATOM 573 C C . THR A 1 71 ? 62.036 147.623 -10.062 1.00 227.22 ? 70 THR A C 1 ATOM 574 O O . THR A 1 71 ? 61.002 148.169 -9.670 1.00 227.22 ? 70 THR A O 1 ATOM 575 C CB . THR A 1 71 ? 64.440 148.014 -9.298 1.00 227.22 ? 70 THR A CB 1 ATOM 576 O OG1 . THR A 1 71 ? 63.918 147.900 -7.967 1.00 227.22 ? 70 THR A OG1 1 ATOM 577 C CG2 . THR A 1 71 ? 65.614 149.009 -9.311 1.00 227.22 ? 70 THR A CG2 1 ATOM 578 N N . PRO A 1 72 ? 62.101 146.295 -10.323 1.00 227.22 ? 71 PRO A N 1 ATOM 579 C CA . PRO A 1 72 ? 60.947 145.406 -10.102 1.00 227.22 ? 71 PRO A CA 1 ATOM 580 C C . PRO A 1 72 ? 60.309 145.559 -8.721 1.00 227.22 ? 71 PRO A C 1 ATOM 581 O O . PRO A 1 72 ? 59.079 145.599 -8.602 1.00 227.22 ? 71 PRO A O 1 ATOM 582 C CB . PRO A 1 72 ? 61.564 144.010 -10.211 1.00 227.22 ? 71 PRO A CB 1 ATOM 583 C CG . PRO A 1 72 ? 62.729 144.184 -11.115 1.00 227.22 ? 71 PRO A CG 1 ATOM 584 C CD . PRO A 1 72 ? 63.266 145.557 -10.856 1.00 227.22 ? 71 PRO A CD 1 ATOM 585 N N . LEU A 1 73 ? 61.169 145.663 -7.708 1.00 227.22 ? 72 LEU A N 1 ATOM 586 C CA . LEU A 1 73 ? 60.795 145.665 -6.293 1.00 227.22 ? 72 LEU A CA 1 ATOM 587 C C . LEU A 1 73 ? 60.123 146.957 -5.823 1.00 227.22 ? 72 LEU A C 1 ATOM 588 O O . LEU A 1 73 ? 59.114 146.920 -5.110 1.00 227.22 ? 72 LEU A O 1 ATOM 589 C CB . LEU A 1 73 ? 62.036 145.389 -5.445 1.00 227.22 ? 72 LEU A CB 1 ATOM 590 C CG . LEU A 1 73 ? 61.836 144.726 -4.088 1.00 227.22 ? 72 LEU A CG 1 ATOM 591 C CD1 . LEU A 1 73 ? 61.408 143.269 -4.229 1.00 227.22 ? 72 LEU A CD1 1 ATOM 592 C CD2 . LEU A 1 73 ? 63.128 144.833 -3.317 1.00 227.22 ? 72 LEU A CD2 1 ATOM 593 N N . ASN A 1 74 ? 60.697 148.091 -6.217 1.00 227.22 ? 73 ASN A N 1 ATOM 594 C CA . ASN A 1 74 ? 60.125 149.397 -5.917 1.00 227.22 ? 73 ASN A CA 1 ATOM 595 C C . ASN A 1 74 ? 58.736 149.532 -6.526 1.00 227.22 ? 73 ASN A C 1 ATOM 596 O O . ASN A 1 74 ? 57.828 150.089 -5.903 1.00 227.22 ? 73 ASN A O 1 ATOM 597 C CB . ASN A 1 74 ? 61.028 150.512 -6.448 1.00 227.22 ? 73 ASN A CB 1 ATOM 598 C CG . ASN A 1 74 ? 62.506 150.237 -6.213 1.00 227.22 ? 73 ASN A CG 1 ATOM 599 O OD1 . ASN A 1 74 ? 63.322 150.367 -7.128 1.00 227.22 ? 73 ASN A OD1 1 ATOM 600 N ND2 . ASN A 1 74 ? 62.858 149.858 -4.987 1.00 227.22 ? 73 ASN A ND2 1 ATOM 601 N N . TYR A 1 75 ? 58.590 149.004 -7.743 1.00 227.22 ? 74 TYR A N 1 ATOM 602 C CA . TYR A 1 75 ? 57.332 149.032 -8.494 1.00 227.22 ? 74 TYR A CA 1 ATOM 603 C C . TYR A 1 75 ? 56.190 148.348 -7.750 1.00 227.22 ? 74 TYR A C 1 ATOM 604 O O . TYR A 1 75 ? 55.201 148.989 -7.373 1.00 227.22 ? 74 TYR A O 1 ATOM 605 C CB . TYR A 1 75 ? 57.511 148.398 -9.888 1.00 227.22 ? 74 TYR A CB 1 ATOM 606 C CG . TYR A 1 75 ? 57.862 149.395 -10.975 1.00 227.22 ? 74 TYR A CG 1 ATOM 607 C CD1 . TYR A 1 75 ? 56.872 150.179 -11.577 1.00 227.22 ? 74 TYR A CD1 1 ATOM 608 C CD2 . TYR A 1 75 ? 59.182 149.561 -11.400 1.00 227.22 ? 74 TYR A CD2 1 ATOM 609 C CE1 . TYR A 1 75 ? 57.193 151.108 -12.576 1.00 227.22 ? 74 TYR A CE1 1 ATOM 610 C CE2 . TYR A 1 75 ? 59.516 150.483 -12.398 1.00 227.22 ? 74 TYR A CE2 1 ATOM 611 C CZ . TYR A 1 75 ? 58.519 151.253 -12.985 1.00 227.22 ? 74 TYR A CZ 1 ATOM 612 O OH . TYR A 1 75 ? 58.853 152.164 -13.969 1.00 227.22 ? 74 TYR A OH 1 ATOM 613 N N . ILE A 1 76 ? 56.346 147.048 -7.530 1.00 227.22 ? 75 ILE A N 1 ATOM 614 C CA . ILE A 1 76 ? 55.293 146.250 -6.934 1.00 227.22 ? 75 ILE A CA 1 ATOM 615 C C . ILE A 1 76 ? 54.799 146.874 -5.636 1.00 227.22 ? 75 ILE A C 1 ATOM 616 O O . ILE A 1 76 ? 53.599 146.891 -5.383 1.00 227.22 ? 75 ILE A O 1 ATOM 617 C CB . ILE A 1 76 ? 55.743 144.787 -6.719 1.00 227.22 ? 75 ILE A CB 1 ATOM 618 C CG1 . ILE A 1 76 ? 56.255 144.174 -8.037 1.00 227.22 ? 75 ILE A CG1 1 ATOM 619 C CG2 . ILE A 1 76 ? 54.617 143.947 -6.129 1.00 227.22 ? 75 ILE A CG2 1 ATOM 620 C CD1 . ILE A 1 76 ? 55.298 144.278 -9.234 1.00 227.22 ? 75 ILE A CD1 1 ATOM 621 N N . LEU A 1 77 ? 55.722 147.417 -4.843 1.00 227.22 ? 76 LEU A N 1 ATOM 622 C CA . LEU A 1 77 ? 55.385 148.011 -3.543 1.00 227.22 ? 76 LEU A CA 1 ATOM 623 C C . LEU A 1 77 ? 54.712 149.380 -3.613 1.00 227.22 ? 76 LEU A C 1 ATOM 624 O O . LEU A 1 77 ? 53.853 149.690 -2.770 1.00 227.22 ? 76 LEU A O 1 ATOM 625 C CB . LEU A 1 77 ? 56.616 148.077 -2.648 1.00 227.22 ? 76 LEU A CB 1 ATOM 626 C CG . LEU A 1 77 ? 56.907 146.748 -1.963 1.00 227.22 ? 76 LEU A CG 1 ATOM 627 C CD1 . LEU A 1 77 ? 58.400 146.539 -1.865 1.00 227.22 ? 76 LEU A CD1 1 ATOM 628 C CD2 . LEU A 1 77 ? 56.228 146.675 -0.599 1.00 227.22 ? 76 LEU A CD2 1 ATOM 629 N N . LEU A 1 78 ? 55.120 150.195 -4.593 1.00 227.22 ? 77 LEU A N 1 ATOM 630 C CA . LEU A 1 78 ? 54.469 151.477 -4.876 1.00 227.22 ? 77 LEU A CA 1 ATOM 631 C C . LEU A 1 78 ? 53.028 151.193 -5.276 1.00 227.22 ? 77 LEU A C 1 ATOM 632 O O . LEU A 1 78 ? 52.096 151.869 -4.832 1.00 227.22 ? 77 LEU A O 1 ATOM 633 C CB . LEU A 1 78 ? 55.191 152.226 -5.998 1.00 227.22 ? 77 LEU A CB 1 ATOM 634 C CG . LEU A 1 78 ? 54.519 153.510 -6.504 1.00 227.22 ? 77 LEU A CG 1 ATOM 635 C CD1 . LEU A 1 78 ? 55.083 154.729 -5.802 1.00 227.22 ? 77 LEU A CD1 1 ATOM 636 C CD2 . LEU A 1 78 ? 54.661 153.650 -8.016 1.00 227.22 ? 77 LEU A CD2 1 ATOM 637 N N . ASN A 1 79 ? 52.870 150.180 -6.121 1.00 227.22 ? 78 ASN A N 1 ATOM 638 C CA . ASN A 1 79 ? 51.576 149.602 -6.430 1.00 227.22 ? 78 ASN A CA 1 ATOM 639 C C . ASN A 1 79 ? 50.778 149.284 -5.151 1.00 227.22 ? 78 ASN A C 1 ATOM 640 O O . ASN A 1 79 ? 49.637 149.737 -5.001 1.00 227.22 ? 78 ASN A O 1 ATOM 641 C CB . ASN A 1 79 ? 51.786 148.356 -7.298 1.00 227.22 ? 78 ASN A CB 1 ATOM 642 C CG . ASN A 1 79 ? 50.599 147.425 -7.294 1.00 227.22 ? 78 ASN A CG 1 ATOM 643 O OD1 . ASN A 1 79 ? 49.475 147.826 -7.591 1.00 227.22 ? 78 ASN A OD1 1 ATOM 644 N ND2 . ASN A 1 79 ? 50.847 146.163 -6.969 1.00 227.22 ? 78 ASN A ND2 1 ATOM 645 N N . LEU A 1 80 ? 51.401 148.537 -4.232 1.00 227.22 ? 79 LEU A N 1 ATOM 646 C CA . LEU A 1 80 ? 50.776 148.099 -2.973 1.00 227.22 ? 79 LEU A CA 1 ATOM 647 C C . LEU A 1 80 ? 50.361 149.258 -2.096 1.00 227.22 ? 79 LEU A C 1 ATOM 648 O O . LEU A 1 80 ? 49.297 149.225 -1.483 1.00 227.22 ? 79 LEU A O 1 ATOM 649 C CB . LEU A 1 80 ? 51.712 147.182 -2.186 1.00 227.22 ? 79 LEU A CB 1 ATOM 650 C CG . LEU A 1 80 ? 51.835 145.731 -2.646 1.00 227.22 ? 79 LEU A CG 1 ATOM 651 C CD1 . LEU A 1 80 ? 53.017 145.068 -1.963 1.00 227.22 ? 79 LEU A CD1 1 ATOM 652 C CD2 . LEU A 1 80 ? 50.555 144.956 -2.386 1.00 227.22 ? 79 LEU A CD2 1 ATOM 653 N N . ALA A 1 81 ? 51.214 150.275 -2.036 1.00 227.22 ? 80 ALA A N 1 ATOM 654 C CA . ALA A 1 81 ? 50.904 151.494 -1.310 1.00 227.22 ? 80 ALA A CA 1 ATOM 655 C C . ALA A 1 81 ? 49.562 152.052 -1.776 1.00 227.22 ? 80 ALA A C 1 ATOM 656 O O . ALA A 1 81 ? 48.707 152.399 -0.956 1.00 227.22 ? 80 ALA A O 1 ATOM 657 C CB . ALA A 1 81 ? 52.012 152.516 -1.493 1.00 227.22 ? 80 ALA A CB 1 ATOM 658 N N . VAL A 1 82 ? 49.382 152.101 -3.096 1.00 227.22 ? 81 VAL A N 1 ATOM 659 C CA . VAL A 1 82 ? 48.141 152.566 -3.716 1.00 227.22 ? 81 VAL A CA 1 ATOM 660 C C . VAL A 1 82 ? 46.982 151.610 -3.416 1.00 227.22 ? 81 VAL A C 1 ATOM 661 O O . VAL A 1 82 ? 45.841 152.042 -3.241 1.00 227.22 ? 81 VAL A O 1 ATOM 662 C CB . VAL A 1 82 ? 48.318 152.762 -5.242 1.00 227.22 ? 81 VAL A CB 1 ATOM 663 C CG1 . VAL A 1 82 ? 47.027 153.233 -5.898 1.00 227.22 ? 81 VAL A CG1 1 ATOM 664 C CG2 . VAL A 1 82 ? 49.431 153.761 -5.513 1.00 227.22 ? 81 VAL A CG2 1 ATOM 665 N N . ALA A 1 83 ? 47.285 150.315 -3.343 1.00 227.22 ? 82 ALA A N 1 ATOM 666 C CA . ALA A 1 83 ? 46.298 149.300 -2.968 1.00 227.22 ? 82 ALA A CA 1 ATOM 667 C C . ALA A 1 83 ? 45.841 149.486 -1.526 1.00 227.22 ? 82 ALA A C 1 ATOM 668 O O . ALA A 1 83 ? 44.663 149.300 -1.208 1.00 227.22 ? 82 ALA A O 1 ATOM 669 C CB . ALA A 1 83 ? 46.878 147.912 -3.152 1.00 227.22 ? 82 ALA A CB 1 ATOM 670 N N . ASP A 1 84 ? 46.797 149.849 -0.672 1.00 227.22 ? 83 ASP A N 1 ATOM 671 C CA . ASP A 1 84 ? 46.563 150.101 0.743 1.00 227.22 ? 83 ASP A CA 1 ATOM 672 C C . ASP A 1 84 ? 45.728 151.361 0.954 1.00 227.22 ? 83 ASP A C 1 ATOM 673 O O . ASP A 1 84 ? 44.664 151.312 1.571 1.00 227.22 ? 83 ASP A O 1 ATOM 674 C CB . ASP A 1 84 ? 47.901 150.236 1.473 1.00 227.22 ? 83 ASP A CB 1 ATOM 675 C CG . ASP A 1 84 ? 48.639 148.914 1.619 1.00 227.22 ? 83 ASP A CG 1 ATOM 676 O OD1 . ASP A 1 84 ? 48.133 147.880 1.140 1.00 227.22 ? 83 ASP A OD1 1 ATOM 677 O OD2 . ASP A 1 84 ? 49.726 148.904 2.232 1.00 227.22 ? 83 ASP A OD2 1 ATOM 678 N N . LEU A 1 85 ? 46.215 152.483 0.431 1.00 227.22 ? 84 LEU A N 1 ATOM 679 C CA . LEU A 1 85 ? 45.540 153.772 0.577 1.00 227.22 ? 84 LEU A CA 1 ATOM 680 C C . LEU A 1 85 ? 44.082 153.715 0.135 1.00 227.22 ? 84 LEU A C 1 ATOM 681 O O . LEU A 1 85 ? 43.215 154.322 0.758 1.00 227.22 ? 84 LEU A O 1 ATOM 682 C CB . LEU A 1 85 ? 46.288 154.859 -0.200 1.00 227.22 ? 84 LEU A CB 1 ATOM 683 C CG . LEU A 1 85 ? 47.632 155.345 0.356 1.00 227.22 ? 84 LEU A CG 1 ATOM 684 C CD1 . LEU A 1 85 ? 48.575 155.716 -0.775 1.00 227.22 ? 84 LEU A CD1 1 ATOM 685 C CD2 . LEU A 1 85 ? 47.470 156.512 1.328 1.00 227.22 ? 84 LEU A CD2 1 ATOM 686 N N . PHE A 1 86 ? 43.820 152.976 -0.936 1.00 227.22 ? 85 PHE A N 1 ATOM 687 C CA . PHE A 1 86 ? 42.457 152.803 -1.419 1.00 227.22 ? 85 PHE A CA 1 ATOM 688 C C . PHE A 1 86 ? 41.581 152.116 -0.379 1.00 227.22 ? 85 PHE A C 1 ATOM 689 O O . PHE A 1 86 ? 40.426 152.498 -0.193 1.00 227.22 ? 85 PHE A O 1 ATOM 690 C CB . PHE A 1 86 ? 42.424 152.083 -2.776 1.00 227.22 ? 85 PHE A CB 1 ATOM 691 C CG . PHE A 1 86 ? 42.439 153.024 -3.952 1.00 227.22 ? 85 PHE A CG 1 ATOM 692 C CD1 . PHE A 1 86 ? 41.254 153.573 -4.434 1.00 227.22 ? 85 PHE A CD1 1 ATOM 693 C CD2 . PHE A 1 86 ? 43.636 153.386 -4.562 1.00 227.22 ? 85 PHE A CD2 1 ATOM 694 C CE1 . PHE A 1 86 ? 41.262 154.455 -5.511 1.00 227.22 ? 85 PHE A CE1 1 ATOM 695 C CE2 . PHE A 1 86 ? 43.652 154.267 -5.639 1.00 227.22 ? 85 PHE A CE2 1 ATOM 696 C CZ . PHE A 1 86 ? 42.463 154.801 -6.115 1.00 227.22 ? 85 PHE A CZ 1 ATOM 697 N N . MET A 1 87 ? 42.137 151.122 0.310 1.00 227.22 ? 86 MET A N 1 ATOM 698 C CA . MET A 1 87 ? 41.455 150.538 1.458 1.00 227.22 ? 86 MET A CA 1 ATOM 699 C C . MET A 1 87 ? 41.250 151.609 2.520 1.00 227.22 ? 86 MET A C 1 ATOM 700 O O . MET A 1 87 ? 40.136 151.788 3.006 1.00 227.22 ? 86 MET A O 1 ATOM 701 C CB . MET A 1 87 ? 42.238 149.365 2.040 1.00 227.22 ? 86 MET A CB 1 ATOM 702 C CG . MET A 1 87 ? 41.942 148.050 1.372 1.00 227.22 ? 86 MET A CG 1 ATOM 703 S SD . MET A 1 87 ? 42.332 146.626 2.401 1.00 227.22 ? 86 MET A SD 1 ATOM 704 C CE . MET A 1 87 ? 44.120 146.597 2.305 1.00 227.22 ? 86 MET A CE 1 ATOM 705 N N . VAL A 1 88 ? 42.326 152.332 2.843 1.00 227.22 ? 87 VAL A N 1 ATOM 706 C CA . VAL A 1 88 ? 42.316 153.382 3.870 1.00 227.22 ? 87 VAL A CA 1 ATOM 707 C C . VAL A 1 88 ? 41.216 154.435 3.655 1.00 227.22 ? 87 VAL A C 1 ATOM 708 O O . VAL A 1 88 ? 40.503 154.784 4.598 1.00 227.22 ? 87 VAL A O 1 ATOM 709 C CB . VAL A 1 88 ? 43.725 154.029 4.031 1.00 227.22 ? 87 VAL A CB 1 ATOM 710 C CG1 . VAL A 1 88 ? 43.656 155.367 4.749 1.00 227.22 ? 87 VAL A CG1 1 ATOM 711 C CG2 . VAL A 1 88 ? 44.656 153.083 4.771 1.00 227.22 ? 87 VAL A CG2 1 ATOM 712 N N . PHE A 1 89 ? 41.065 154.909 2.417 1.00 227.22 ? 88 PHE A N 1 ATOM 713 C CA . PHE A 1 89 ? 40.078 155.953 2.086 1.00 227.22 ? 88 PHE A CA 1 ATOM 714 C C . PHE A 1 89 ? 38.700 155.430 1.674 1.00 227.22 ? 88 PHE A C 1 ATOM 715 O O . PHE A 1 89 ? 37.676 156.020 2.023 1.00 227.22 ? 88 PHE A O 1 ATOM 716 C CB . PHE A 1 89 ? 40.618 156.876 0.990 1.00 227.22 ? 88 PHE A CB 1 ATOM 717 C CG . PHE A 1 89 ? 41.683 157.818 1.464 1.00 227.22 ? 88 PHE A CG 1 ATOM 718 C CD1 . PHE A 1 89 ? 41.351 159.098 1.900 1.00 227.22 ? 88 PHE A CD1 1 ATOM 719 C CD2 . PHE A 1 89 ? 43.022 157.428 1.477 1.00 227.22 ? 88 PHE A CD2 1 ATOM 720 C CE1 . PHE A 1 89 ? 42.339 159.980 2.341 1.00 227.22 ? 88 PHE A CE1 1 ATOM 721 C CE2 . PHE A 1 89 ? 44.020 158.301 1.917 1.00 227.22 ? 88 PHE A CE2 1 ATOM 722 C CZ . PHE A 1 89 ? 43.678 159.579 2.349 1.00 227.22 ? 88 PHE A CZ 1 ATOM 723 N N . GLY A 1 90 ? 38.681 154.339 0.919 1.00 227.22 ? 89 GLY A N 1 ATOM 724 C CA . GLY A 1 90 ? 37.434 153.792 0.412 1.00 227.22 ? 89 GLY A CA 1 ATOM 725 C C . GLY A 1 90 ? 36.838 152.787 1.366 1.00 227.22 ? 89 GLY A C 1 ATOM 726 O O . GLY A 1 90 ? 35.733 152.977 1.867 1.00 227.22 ? 89 GLY A O 1 ATOM 727 N N . GLY A 1 91 ? 37.585 151.718 1.613 1.00 227.22 ? 90 GLY A N 1 ATOM 728 C CA . GLY A 1 91 ? 37.117 150.619 2.443 1.00 227.22 ? 90 GLY A CA 1 ATOM 729 C C . GLY A 1 91 ? 37.068 150.926 3.928 1.00 227.22 ? 90 GLY A C 1 ATOM 730 O O . GLY A 1 91 ? 36.206 150.406 4.642 1.00 227.22 ? 90 GLY A O 1 ATOM 731 N N . PHE A 1 92 ? 37.985 151.777 4.393 1.00 227.22 ? 91 PHE A N 1 ATOM 732 C CA . PHE A 1 92 ? 38.147 152.020 5.826 1.00 227.22 ? 91 PHE A CA 1 ATOM 733 C C . PHE A 1 92 ? 37.271 153.125 6.401 1.00 227.22 ? 91 PHE A C 1 ATOM 734 O O . PHE A 1 92 ? 36.587 152.905 7.394 1.00 227.22 ? 91 PHE A O 1 ATOM 735 C CB . PHE A 1 92 ? 39.616 152.197 6.209 1.00 227.22 ? 91 PHE A CB 1 ATOM 736 C CG . PHE A 1 92 ? 40.426 150.936 6.102 1.00 227.22 ? 91 PHE A CG 1 ATOM 737 C CD1 . PHE A 1 92 ? 39.805 149.696 5.976 1.00 227.22 ? 91 PHE A CD1 1 ATOM 738 C CD2 . PHE A 1 92 ? 41.812 150.983 6.160 1.00 227.22 ? 91 PHE A CD2 1 ATOM 739 C CE1 . PHE A 1 92 ? 40.552 148.536 5.887 1.00 227.22 ? 91 PHE A CE1 1 ATOM 740 C CE2 . PHE A 1 92 ? 42.567 149.823 6.073 1.00 227.22 ? 91 PHE A CE2 1 ATOM 741 C CZ . PHE A 1 92 ? 41.936 148.598 5.938 1.00 227.22 ? 91 PHE A CZ 1 ATOM 742 N N . THR A 1 93 ? 37.271 154.303 5.782 1.00 227.22 ? 92 THR A N 1 ATOM 743 C CA . THR A 1 93 ? 36.389 155.383 6.231 1.00 227.22 ? 92 THR A CA 1 ATOM 744 C C . THR A 1 93 ? 34.920 154.962 6.196 1.00 227.22 ? 92 THR A C 1 ATOM 745 O O . THR A 1 93 ? 34.086 155.549 6.874 1.00 227.22 ? 92 THR A O 1 ATOM 746 C CB . THR A 1 93 ? 36.565 156.678 5.411 1.00 227.22 ? 92 THR A CB 1 ATOM 747 O OG1 . THR A 1 93 ? 36.334 156.411 4.021 1.00 227.22 ? 92 THR A OG1 1 ATOM 748 C CG2 . THR A 1 93 ? 37.960 157.248 5.598 1.00 227.22 ? 92 THR A CG2 1 ATOM 749 N N . THR A 1 94 ? 34.608 153.944 5.402 1.00 227.22 ? 93 THR A N 1 ATOM 750 C CA . THR A 1 94 ? 33.252 153.425 5.351 1.00 227.22 ? 93 THR A CA 1 ATOM 751 C C . THR A 1 94 ? 33.004 152.617 6.617 1.00 227.22 ? 93 THR A C 1 ATOM 752 O O . THR A 1 94 ? 31.991 152.822 7.275 1.00 227.22 ? 93 THR A O 1 ATOM 753 C CB . THR A 1 94 ? 32.959 152.578 4.066 1.00 227.22 ? 93 THR A CB 1 ATOM 754 O OG1 . THR A 1 94 ? 33.553 153.190 2.910 1.00 227.22 ? 93 THR A OG1 1 ATOM 755 C CG2 . THR A 1 94 ? 31.455 152.452 3.827 1.00 227.22 ? 93 THR A CG2 1 ATOM 756 N N . THR A 1 95 ? 33.942 151.729 6.963 1.00 227.22 ? 94 THR A N 1 ATOM 757 C CA . THR A 1 95 ? 33.815 150.859 8.155 1.00 227.22 ? 94 THR A CA 1 ATOM 758 C C . THR A 1 95 ? 33.952 151.601 9.494 1.00 227.22 ? 94 THR A C 1 ATOM 759 O O . THR A 1 95 ? 33.235 151.302 10.455 1.00 227.22 ? 94 THR A O 1 ATOM 760 C CB . THR A 1 95 ? 34.749 149.588 8.107 1.00 227.22 ? 94 THR A CB 1 ATOM 761 O OG1 . THR A 1 95 ? 34.800 148.957 9.393 1.00 227.22 ? 94 THR A OG1 1 ATOM 762 C CG2 . THR A 1 95 ? 36.157 149.929 7.688 1.00 227.22 ? 94 THR A CG2 1 ATOM 763 N N . LEU A 1 96 ? 34.871 152.563 9.539 1.00 227.22 ? 95 LEU A N 1 ATOM 764 C CA . LEU A 1 96 ? 35.023 153.477 10.664 1.00 227.22 ? 95 LEU A CA 1 ATOM 765 C C . LEU A 1 96 ? 33.672 154.053 11.089 1.00 227.22 ? 95 LEU A C 1 ATOM 766 O O . LEU A 1 96 ? 33.145 153.692 12.133 1.00 227.22 ? 95 LEU A O 1 ATOM 767 C CB . LEU A 1 96 ? 35.957 154.602 10.258 1.00 227.22 ? 95 LEU A CB 1 ATOM 768 C CG . LEU A 1 96 ? 36.225 155.648 11.319 1.00 227.22 ? 95 LEU A CG 1 ATOM 769 C CD1 . LEU A 1 96 ? 37.680 155.570 11.694 1.00 227.22 ? 95 LEU A CD1 1 ATOM 770 C CD2 . LEU A 1 96 ? 35.881 157.014 10.768 1.00 227.22 ? 95 LEU A CD2 1 ATOM 771 N N . TYR A 1 97 ? 33.122 154.940 10.260 1.00 227.22 ? 96 TYR A N 1 ATOM 772 C CA . TYR A 1 97 ? 31.772 155.493 10.422 1.00 227.22 ? 96 TYR A CA 1 ATOM 773 C C . TYR A 1 97 ? 30.771 154.427 10.851 1.00 227.22 ? 96 TYR A C 1 ATOM 774 O O . TYR A 1 97 ? 29.909 154.680 11.689 1.00 227.22 ? 96 TYR A O 1 ATOM 775 C CB . TYR A 1 97 ? 31.306 156.112 9.091 1.00 227.22 ? 96 TYR A CB 1 ATOM 776 C CG . TYR A 1 97 ? 30.035 156.954 9.140 1.00 227.22 ? 96 TYR A CG 1 ATOM 777 C CD1 . TYR A 1 97 ? 28.778 156.365 9.294 1.00 227.22 ? 96 TYR A CD1 1 ATOM 778 C CD2 . TYR A 1 97 ? 30.092 158.342 8.986 1.00 227.22 ? 96 TYR A CD2 1 ATOM 779 C CE1 . TYR A 1 97 ? 27.621 157.139 9.331 1.00 227.22 ? 96 TYR A CE1 1 ATOM 780 C CE2 . TYR A 1 97 ? 28.935 159.123 9.015 1.00 227.22 ? 96 TYR A CE2 1 ATOM 781 C CZ . TYR A 1 97 ? 27.703 158.515 9.186 1.00 227.22 ? 96 TYR A CZ 1 ATOM 782 O OH . TYR A 1 97 ? 26.554 159.279 9.216 1.00 227.22 ? 96 TYR A OH 1 ATOM 783 N N . THR A 1 98 ? 30.893 153.243 10.261 1.00 227.22 ? 97 THR A N 1 ATOM 784 C CA . THR A 1 98 ? 29.981 152.145 10.526 1.00 227.22 ? 97 THR A CA 1 ATOM 785 C C . THR A 1 98 ? 30.125 151.616 11.955 1.00 227.22 ? 97 THR A C 1 ATOM 786 O O . THR A 1 98 ? 29.131 151.248 12.581 1.00 227.22 ? 97 THR A O 1 ATOM 787 C CB . THR A 1 98 ? 30.173 151.015 9.503 1.00 227.22 ? 97 THR A CB 1 ATOM 788 O OG1 . THR A 1 98 ? 30.104 151.561 8.182 1.00 227.22 ? 97 THR A OG1 1 ATOM 789 C CG2 . THR A 1 98 ? 29.096 149.952 9.647 1.00 227.22 ? 97 THR A CG2 1 ATOM 790 N N . SER A 1 99 ? 31.348 151.592 12.479 1.00 227.22 ? 98 SER A N 1 ATOM 791 C CA . SER A 1 99 ? 31.565 151.136 13.853 1.00 227.22 ? 98 SER A CA 1 ATOM 792 C C . SER A 1 99 ? 31.028 152.111 14.901 1.00 227.22 ? 98 SER A C 1 ATOM 793 O O . SER A 1 99 ? 30.538 151.694 15.949 1.00 227.22 ? 98 SER A O 1 ATOM 794 C CB . SER A 1 99 ? 33.041 150.838 14.102 1.00 227.22 ? 98 SER A CB 1 ATOM 795 O OG . SER A 1 99 ? 33.417 149.601 13.528 1.00 227.22 ? 98 SER A OG 1 ATOM 796 N N . LEU A 1 100 ? 31.099 153.405 14.599 1.00 227.22 ? 99 LEU A N 1 ATOM 797 C CA . LEU A 1 100 ? 30.682 154.446 15.536 1.00 227.22 ? 99 LEU A CA 1 ATOM 798 C C . LEU A 1 100 ? 29.177 154.702 15.610 1.00 227.22 ? 99 LEU A C 1 ATOM 799 O O . LEU A 1 100 ? 28.729 155.489 16.441 1.00 227.22 ? 99 LEU A O 1 ATOM 800 C CB . LEU A 1 100 ? 31.422 155.756 15.251 1.00 227.22 ? 99 LEU A CB 1 ATOM 801 C CG . LEU A 1 100 ? 32.816 155.904 15.872 1.00 227.22 ? 99 LEU A CG 1 ATOM 802 C CD1 . LEU A 1 100 ? 33.585 157.070 15.266 1.00 227.22 ? 99 LEU A CD1 1 ATOM 803 C CD2 . LEU A 1 100 ? 32.743 156.047 17.387 1.00 227.22 ? 99 LEU A CD2 1 ATOM 804 N N . HIS A 1 101 ? 28.399 154.053 14.750 1.00 227.22 ? 100 HIS A N 1 ATOM 805 C CA . HIS A 1 101 ? 26.942 154.151 14.822 1.00 227.22 ? 100 HIS A CA 1 ATOM 806 C C . HIS A 1 101 ? 26.317 152.777 14.992 1.00 227.22 ? 100 HIS A C 1 ATOM 807 O O . HIS A 1 101 ? 25.117 152.649 15.240 1.00 227.22 ? 100 HIS A O 1 ATOM 808 C CB . HIS A 1 101 ? 26.377 154.856 13.588 1.00 227.22 ? 100 HIS A CB 1 ATOM 809 C CG . HIS A 1 101 ? 26.572 156.341 13.597 1.00 227.22 ? 100 HIS A CG 1 ATOM 810 N ND1 . HIS A 1 101 ? 27.816 156.929 13.524 1.00 227.22 ? 100 HIS A ND1 1 ATOM 811 C CD2 . HIS A 1 101 ? 25.678 157.357 13.657 1.00 227.22 ? 100 HIS A CD2 1 ATOM 812 C CE1 . HIS A 1 101 ? 27.681 158.243 13.544 1.00 227.22 ? 100 HIS A CE1 1 ATOM 813 N NE2 . HIS A 1 101 ? 26.394 158.529 13.623 1.00 227.22 ? 100 HIS A NE2 1 ATOM 814 N N . GLY A 1 102 ? 27.150 151.752 14.866 1.00 227.22 ? 101 GLY A N 1 ATOM 815 C CA . GLY A 1 102 ? 26.721 150.377 15.058 1.00 227.22 ? 101 GLY A CA 1 ATOM 816 C C . GLY A 1 102 ? 25.856 149.828 13.940 1.00 227.22 ? 101 GLY A C 1 ATOM 817 O O . GLY A 1 102 ? 24.972 149.004 14.195 1.00 227.22 ? 101 GLY A O 1 ATOM 818 N N . TYR A 1 103 ? 26.107 150.294 12.712 1.00 227.22 ? 102 TYR A N 1 ATOM 819 C CA . TYR A 1 103 ? 25.470 149.760 11.493 1.00 227.22 ? 102 TYR A CA 1 ATOM 820 C C . TYR A 1 103 ? 25.792 150.549 10.217 1.00 227.22 ? 102 TYR A C 1 ATOM 821 O O . TYR A 1 103 ? 26.257 151.691 10.284 1.00 227.22 ? 102 TYR A O 1 ATOM 822 C CB . TYR A 1 103 ? 23.946 149.606 11.674 1.00 227.22 ? 102 TYR A CB 1 ATOM 823 C CG . TYR A 1 103 ? 23.138 150.889 11.674 1.00 227.22 ? 102 TYR A CG 1 ATOM 824 C CD1 . TYR A 1 103 ? 23.481 151.963 12.494 1.00 227.22 ? 102 TYR A CD1 1 ATOM 825 C CD2 . TYR A 1 103 ? 22.006 151.012 10.872 1.00 227.22 ? 102 TYR A CD2 1 ATOM 826 C CE1 . TYR A 1 103 ? 22.728 153.135 12.496 1.00 227.22 ? 102 TYR A CE1 1 ATOM 827 C CE2 . TYR A 1 103 ? 21.250 152.176 10.868 1.00 227.22 ? 102 TYR A CE2 1 ATOM 828 C CZ . TYR A 1 103 ? 21.612 153.232 11.680 1.00 227.22 ? 102 TYR A CZ 1 ATOM 829 O OH . TYR A 1 103 ? 20.862 154.386 11.675 1.00 227.22 ? 102 TYR A OH 1 ATOM 830 N N . PHE A 1 104 ? 25.557 149.921 9.062 1.00 227.22 ? 103 PHE A N 1 ATOM 831 C CA . PHE A 1 104 ? 25.676 150.592 7.762 1.00 227.22 ? 103 PHE A CA 1 ATOM 832 C C . PHE A 1 104 ? 24.523 151.558 7.541 1.00 227.22 ? 103 PHE A C 1 ATOM 833 O O . PHE A 1 104 ? 23.458 151.181 7.042 1.00 227.22 ? 103 PHE A O 1 ATOM 834 C CB . PHE A 1 104 ? 25.779 149.591 6.602 1.00 227.22 ? 103 PHE A CB 1 ATOM 835 C CG . PHE A 1 104 ? 27.193 149.251 6.223 1.00 227.22 ? 103 PHE A CG 1 ATOM 836 C CD1 . PHE A 1 104 ? 27.950 150.122 5.445 1.00 227.22 ? 103 PHE A CD1 1 ATOM 837 C CD2 . PHE A 1 104 ? 27.777 148.065 6.653 1.00 227.22 ? 103 PHE A CD2 1 ATOM 838 C CE1 . PHE A 1 104 ? 29.267 149.812 5.101 1.00 227.22 ? 103 PHE A CE1 1 ATOM 839 C CE2 . PHE A 1 104 ? 29.093 147.751 6.315 1.00 227.22 ? 103 PHE A CE2 1 ATOM 840 C CZ . PHE A 1 104 ? 29.835 148.622 5.533 1.00 227.22 ? 103 PHE A CZ 1 ATOM 841 N N . VAL A 1 105 ? 24.750 152.805 7.940 1.00 227.22 ? 104 VAL A N 1 ATOM 842 C CA . VAL A 1 105 ? 23.779 153.876 7.759 1.00 227.22 ? 104 VAL A CA 1 ATOM 843 C C . VAL A 1 105 ? 23.825 154.338 6.305 1.00 227.22 ? 104 VAL A C 1 ATOM 844 O O . VAL A 1 105 ? 22.827 154.821 5.763 1.00 227.22 ? 104 VAL A O 1 ATOM 845 C CB . VAL A 1 105 ? 24.027 155.072 8.739 1.00 227.22 ? 104 VAL A CB 1 ATOM 846 C CG1 . VAL A 1 105 ? 24.488 154.578 10.102 1.00 227.22 ? 104 VAL A CG1 1 ATOM 847 C CG2 . VAL A 1 105 ? 25.053 156.047 8.185 1.00 227.22 ? 104 VAL A CG2 1 ATOM 848 N N . PHE A 1 106 ? 24.998 154.167 5.690 1.00 227.22 ? 105 PHE A N 1 ATOM 849 C CA . PHE A 1 106 ? 25.229 154.503 4.289 1.00 227.22 ? 105 PHE A CA 1 ATOM 850 C C . PHE A 1 106 ? 24.582 153.486 3.349 1.00 227.22 ? 105 PHE A C 1 ATOM 851 O O . PHE A 1 106 ? 24.766 153.538 2.130 1.00 227.22 ? 105 PHE A O 1 ATOM 852 C CB . PHE A 1 106 ? 26.732 154.611 4.004 1.00 227.22 ? 105 PHE A CB 1 ATOM 853 C CG . PHE A 1 106 ? 27.329 155.961 4.328 1.00 227.22 ? 105 PHE A CG 1 ATOM 854 C CD1 . PHE A 1 106 ? 28.672 156.068 4.678 1.00 227.22 ? 105 PHE A CD1 1 ATOM 855 C CD2 . PHE A 1 106 ? 26.557 157.122 4.276 1.00 227.22 ? 105 PHE A CD2 1 ATOM 856 C CE1 . PHE A 1 106 ? 29.239 157.308 4.967 1.00 227.22 ? 105 PHE A CE1 1 ATOM 857 C CE2 . PHE A 1 106 ? 27.115 158.367 4.567 1.00 227.22 ? 105 PHE A CE2 1 ATOM 858 C CZ . PHE A 1 106 ? 28.458 158.459 4.910 1.00 227.22 ? 105 PHE A CZ 1 ATOM 859 N N . GLY A 1 107 ? 23.832 152.557 3.931 1.00 227.22 ? 106 GLY A N 1 ATOM 860 C CA . GLY A 1 107 ? 23.023 151.629 3.166 1.00 227.22 ? 106 GLY A CA 1 ATOM 861 C C . GLY A 1 107 ? 23.839 150.560 2.483 1.00 227.22 ? 106 GLY A C 1 ATOM 862 O O . GLY A 1 107 ? 25.040 150.441 2.735 1.00 227.22 ? 106 GLY A O 1 ATOM 863 N N . PRO A 1 108 ? 23.186 149.788 1.597 1.00 227.22 ? 107 PRO A N 1 ATOM 864 C CA . PRO A 1 108 ? 23.791 148.658 0.892 1.00 227.22 ? 107 PRO A CA 1 ATOM 865 C C . PRO A 1 108 ? 25.000 149.083 0.063 1.00 227.22 ? 107 PRO A C 1 ATOM 866 O O . PRO A 1 108 ? 26.023 148.387 0.060 1.00 227.22 ? 107 PRO A O 1 ATOM 867 C CB . PRO A 1 108 ? 22.659 148.156 -0.019 1.00 227.22 ? 107 PRO A CB 1 ATOM 868 C CG . PRO A 1 108 ? 21.409 148.670 0.601 1.00 227.22 ? 107 PRO A CG 1 ATOM 869 C CD . PRO A 1 108 ? 21.778 149.984 1.207 1.00 227.22 ? 107 PRO A CD 1 ATOM 870 N N . THR A 1 109 ? 24.881 150.223 -0.617 1.00 227.22 ? 108 THR A N 1 ATOM 871 C CA . THR A 1 109 ? 25.962 150.748 -1.451 1.00 227.22 ? 108 THR A CA 1 ATOM 872 C C . THR A 1 109 ? 27.221 151.067 -0.622 1.00 227.22 ? 108 THR A C 1 ATOM 873 O O . THR A 1 109 ? 28.341 151.044 -1.150 1.00 227.22 ? 108 THR A O 1 ATOM 874 C CB . THR A 1 109 ? 25.490 151.945 -2.334 1.00 227.22 ? 108 THR A CB 1 ATOM 875 O OG1 . THR A 1 109 ? 26.607 152.505 -3.037 1.00 227.22 ? 108 THR A OG1 1 ATOM 876 C CG2 . THR A 1 109 ? 24.810 153.027 -1.501 1.00 227.22 ? 108 THR A CG2 1 ATOM 877 N N . GLY A 1 110 ? 27.028 151.342 0.669 1.00 227.22 ? 109 GLY A N 1 ATOM 878 C CA . GLY A 1 110 ? 28.146 151.484 1.601 1.00 227.22 ? 109 GLY A CA 1 ATOM 879 C C . GLY A 1 110 ? 28.854 150.153 1.774 1.00 227.22 ? 109 GLY A C 1 ATOM 880 O O . GLY A 1 110 ? 30.087 150.077 1.719 1.00 227.22 ? 109 GLY A O 1 ATOM 881 N N . CYS A 1 111 ? 28.056 149.102 1.967 1.00 227.22 ? 110 CYS A N 1 ATOM 882 C CA . CYS A 1 111 ? 28.559 147.742 2.152 1.00 227.22 ? 110 CYS A CA 1 ATOM 883 C C . CYS A 1 111 ? 29.276 147.268 0.899 1.00 227.22 ? 110 CYS A C 1 ATOM 884 O O . CYS A 1 111 ? 30.094 146.353 0.954 1.00 227.22 ? 110 CYS A O 1 ATOM 885 C CB . CYS A 1 111 ? 27.425 146.780 2.541 1.00 227.22 ? 110 CYS A CB 1 ATOM 886 S SG . CYS A 1 111 ? 27.909 145.061 2.976 1.00 227.22 ? 110 CYS A SG 1 ATOM 887 N N . ASN A 1 112 ? 28.979 147.890 -0.236 1.00 227.22 ? 111 ASN A N 1 ATOM 888 C CA . ASN A 1 112 ? 29.798 147.659 -1.416 1.00 227.22 ? 111 ASN A CA 1 ATOM 889 C C . ASN A 1 112 ? 31.200 148.203 -1.154 1.00 227.22 ? 111 ASN A C 1 ATOM 890 O O . ASN A 1 112 ? 32.128 147.425 -0.905 1.00 227.22 ? 111 ASN A O 1 ATOM 891 C CB . ASN A 1 112 ? 29.177 148.259 -2.693 1.00 227.22 ? 111 ASN A CB 1 ATOM 892 C CG . ASN A 1 112 ? 28.296 147.261 -3.461 1.00 227.22 ? 111 ASN A CG 1 ATOM 893 O OD1 . ASN A 1 112 ? 28.627 146.068 -3.588 1.00 227.22 ? 111 ASN A OD1 1 ATOM 894 N ND2 . ASN A 1 112 ? 27.178 147.763 -3.995 1.00 227.22 ? 111 ASN A ND2 1 ATOM 895 N N . LEU A 1 113 ? 31.330 149.531 -1.159 1.00 227.22 ? 112 LEU A N 1 ATOM 896 C CA . LEU A 1 113 ? 32.624 150.210 -1.010 1.00 227.22 ? 112 LEU A CA 1 ATOM 897 C C . LEU A 1 113 ? 33.542 149.554 0.030 1.00 227.22 ? 112 LEU A C 1 ATOM 898 O O . LEU A 1 113 ? 34.524 148.891 -0.329 1.00 227.22 ? 112 LEU A O 1 ATOM 899 C CB . LEU A 1 113 ? 32.427 151.699 -0.687 1.00 227.22 ? 112 LEU A CB 1 ATOM 900 C CG . LEU A 1 113 ? 31.853 152.640 -1.749 1.00 227.22 ? 112 LEU A CG 1 ATOM 901 C CD1 . LEU A 1 113 ? 31.795 154.065 -1.220 1.00 227.22 ? 112 LEU A CD1 1 ATOM 902 C CD2 . LEU A 1 113 ? 32.656 152.593 -3.034 1.00 227.22 ? 112 LEU A CD2 1 ATOM 903 N N . GLU A 1 114 ? 33.209 149.744 1.307 1.00 227.22 ? 113 GLU A N 1 ATOM 904 C CA . GLU A 1 114 ? 33.913 149.118 2.425 1.00 227.22 ? 113 GLU A CA 1 ATOM 905 C C . GLU A 1 114 ? 34.483 147.751 2.035 1.00 227.22 ? 113 GLU A C 1 ATOM 906 O O . GLU A 1 114 ? 35.691 147.520 2.137 1.00 227.22 ? 113 GLU A O 1 ATOM 907 C CB . GLU A 1 114 ? 32.951 148.971 3.608 1.00 227.22 ? 113 GLU A CB 1 ATOM 908 C CG . GLU A 1 114 ? 33.605 148.706 4.947 1.00 227.22 ? 113 GLU A CG 1 ATOM 909 C CD . GLU A 1 114 ? 34.298 147.363 5.021 1.00 227.22 ? 113 GLU A CD 1 ATOM 910 O OE1 . GLU A 1 114 ? 33.658 146.331 4.711 1.00 227.22 ? 113 GLU A OE1 1 ATOM 911 O OE2 . GLU A 1 114 ? 35.490 147.347 5.389 1.00 227.22 ? 113 GLU A OE2 1 ATOM 912 N N . GLY A 1 115 ? 33.596 146.871 1.570 1.00 227.22 ? 114 GLY A N 1 ATOM 913 C CA . GLY A 1 115 ? 33.925 145.485 1.263 1.00 227.22 ? 114 GLY A CA 1 ATOM 914 C C . GLY A 1 115 ? 34.652 145.295 -0.045 1.00 227.22 ? 114 GLY A C 1 ATOM 915 O O . GLY A 1 115 ? 35.337 144.298 -0.243 1.00 227.22 ? 114 GLY A O 1 ATOM 916 N N . PHE A 1 116 ? 34.511 146.253 -0.945 1.00 227.22 ? 115 PHE A N 1 ATOM 917 C CA . PHE A 1 116 ? 35.192 146.161 -2.217 1.00 227.22 ? 115 PHE A CA 1 ATOM 918 C C . PHE A 1 116 ? 36.690 146.352 -2.036 1.00 227.22 ? 115 PHE A C 1 ATOM 919 O O . PHE A 1 116 ? 37.471 145.427 -2.258 1.00 227.22 ? 115 PHE A O 1 ATOM 920 C CB . PHE A 1 116 ? 34.631 147.181 -3.205 1.00 227.22 ? 115 PHE A CB 1 ATOM 921 C CG . PHE A 1 116 ? 35.295 147.145 -4.548 1.00 227.22 ? 115 PHE A CG 1 ATOM 922 C CD1 . PHE A 1 116 ? 35.066 146.085 -5.423 1.00 227.22 ? 115 PHE A CD1 1 ATOM 923 C CD2 . PHE A 1 116 ? 36.152 148.172 -4.939 1.00 227.22 ? 115 PHE A CD2 1 ATOM 924 C CE1 . PHE A 1 116 ? 35.680 146.047 -6.662 1.00 227.22 ? 115 PHE A CE1 1 ATOM 925 C CE2 . PHE A 1 116 ? 36.773 148.145 -6.182 1.00 227.22 ? 115 PHE A CE2 1 ATOM 926 C CZ . PHE A 1 116 ? 36.535 147.077 -7.045 1.00 227.22 ? 115 PHE A CZ 1 ATOM 927 N N . PHE A 1 117 ? 37.074 147.555 -1.620 1.00 227.22 ? 116 PHE A N 1 ATOM 928 C CA . PHE A 1 117 ? 38.478 147.927 -1.458 1.00 227.22 ? 116 PHE A CA 1 ATOM 929 C C . PHE A 1 117 ? 39.223 146.952 -0.546 1.00 227.22 ? 116 PHE A C 1 ATOM 930 O O . PHE A 1 117 ? 40.345 146.544 -0.860 1.00 227.22 ? 116 PHE A O 1 ATOM 931 C CB . PHE A 1 117 ? 38.595 149.355 -0.918 1.00 227.22 ? 116 PHE A CB 1 ATOM 932 C CG . PHE A 1 117 ? 37.964 150.400 -1.803 1.00 227.22 ? 116 PHE A CG 1 ATOM 933 C CD1 . PHE A 1 117 ? 38.756 151.319 -2.485 1.00 227.22 ? 116 PHE A CD1 1 ATOM 934 C CD2 . PHE A 1 117 ? 36.578 150.476 -1.945 1.00 227.22 ? 116 PHE A CD2 1 ATOM 935 C CE1 . PHE A 1 117 ? 38.177 152.298 -3.293 1.00 227.22 ? 116 PHE A CE1 1 ATOM 936 C CE2 . PHE A 1 117 ? 35.990 151.444 -2.754 1.00 227.22 ? 116 PHE A CE2 1 ATOM 937 C CZ . PHE A 1 117 ? 36.790 152.358 -3.428 1.00 227.22 ? 116 PHE A CZ 1 ATOM 938 N N . ALA A 1 118 ? 38.583 146.580 0.568 1.00 227.22 ? 117 ALA A N 1 ATOM 939 C CA . ALA A 1 118 ? 39.120 145.600 1.514 1.00 227.22 ? 117 ALA A CA 1 ATOM 940 C C . ALA A 1 118 ? 39.326 144.220 0.890 1.00 227.22 ? 117 ALA A C 1 ATOM 941 O O . ALA A 1 118 ? 40.203 143.481 1.336 1.00 227.22 ? 117 ALA A O 1 ATOM 942 C CB . ALA A 1 118 ? 38.241 145.504 2.742 1.00 227.22 ? 117 ALA A CB 1 ATOM 943 N N . THR A 1 119 ? 38.518 143.878 -0.124 1.00 227.22 ? 118 THR A N 1 ATOM 944 C CA . THR A 1 119 ? 38.729 142.664 -0.931 1.00 227.22 ? 118 THR A CA 1 ATOM 945 C C . THR A 1 119 ? 39.761 142.942 -1.992 1.00 227.22 ? 118 THR A C 1 ATOM 946 O O . THR A 1 119 ? 40.484 142.046 -2.417 1.00 227.22 ? 118 THR A O 1 ATOM 947 C CB . THR A 1 119 ? 37.463 142.203 -1.663 1.00 227.22 ? 118 THR A CB 1 ATOM 948 O OG1 . THR A 1 119 ? 36.357 142.193 -0.760 1.00 227.22 ? 118 THR A OG1 1 ATOM 949 C CG2 . THR A 1 119 ? 37.652 140.806 -2.240 1.00 227.22 ? 118 THR A CG2 1 ATOM 950 N N . LEU A 1 120 ? 39.812 144.190 -2.430 1.00 227.22 ? 119 LEU A N 1 ATOM 951 C CA . LEU A 1 120 ? 40.748 144.566 -3.457 1.00 227.22 ? 119 LEU A CA 1 ATOM 952 C C . LEU A 1 120 ? 42.160 144.569 -2.882 1.00 227.22 ? 119 LEU A C 1 ATOM 953 O O . LEU A 1 120 ? 42.990 143.758 -3.295 1.00 227.22 ? 119 LEU A O 1 ATOM 954 C CB . LEU A 1 120 ? 40.376 145.916 -4.076 1.00 227.22 ? 119 LEU A CB 1 ATOM 955 C CG . LEU A 1 120 ? 40.793 146.146 -5.538 1.00 227.22 ? 119 LEU A CG 1 ATOM 956 C CD1 . LEU A 1 120 ? 40.042 145.227 -6.490 1.00 227.22 ? 119 LEU A CD1 1 ATOM 957 C CD2 . LEU A 1 120 ? 40.589 147.603 -5.943 1.00 227.22 ? 119 LEU A CD2 1 ATOM 958 N N . GLY A 1 121 ? 42.415 145.446 -1.910 1.00 227.22 ? 120 GLY A N 1 ATOM 959 C CA . GLY A 1 121 ? 43.750 145.606 -1.312 1.00 227.22 ? 120 GLY A CA 1 ATOM 960 C C . GLY A 1 121 ? 44.392 144.333 -0.779 1.00 227.22 ? 120 GLY A C 1 ATOM 961 O O . GLY A 1 121 ? 45.620 144.233 -0.691 1.00 227.22 ? 120 GLY A O 1 ATOM 962 N N . GLY A 1 122 ? 43.554 143.363 -0.422 1.00 227.22 ? 121 GLY A N 1 ATOM 963 C CA . GLY A 1 122 ? 44.012 142.079 0.085 1.00 227.22 ? 121 GLY A CA 1 ATOM 964 C C . GLY A 1 122 ? 44.402 141.125 -1.020 1.00 227.22 ? 121 GLY A C 1 ATOM 965 O O . GLY A 1 122 ? 45.298 140.303 -0.827 1.00 227.22 ? 121 GLY A O 1 ATOM 966 N N . GLU A 1 123 ? 43.720 141.240 -2.168 1.00 227.22 ? 122 GLU A N 1 ATOM 967 C CA . GLU A 1 123 ? 43.954 140.397 -3.362 1.00 227.22 ? 122 GLU A CA 1 ATOM 968 C C . GLU A 1 123 ? 45.062 140.919 -4.262 1.00 227.22 ? 122 GLU A C 1 ATOM 969 O O . GLU A 1 123 ? 45.872 140.141 -4.757 1.00 227.22 ? 122 GLU A O 1 ATOM 970 C CB . GLU A 1 123 ? 42.677 140.224 -4.192 1.00 227.22 ? 122 GLU A CB 1 ATOM 971 C CG . GLU A 1 123 ? 41.708 139.170 -3.676 1.00 227.22 ? 122 GLU A CG 1 ATOM 972 C CD . GLU A 1 123 ? 42.173 137.740 -3.907 1.00 227.22 ? 122 GLU A CD 1 ATOM 973 O OE1 . GLU A 1 123 ? 43.382 137.506 -4.111 1.00 227.22 ? 122 GLU A OE1 1 ATOM 974 O OE2 . GLU A 1 123 ? 41.312 136.841 -3.870 1.00 227.22 ? 122 GLU A OE2 1 ATOM 975 N N . ILE A 1 124 ? 45.078 142.230 -4.488 1.00 227.22 ? 123 ILE A N 1 ATOM 976 C CA . ILE A 1 124 ? 46.215 142.873 -5.124 1.00 227.22 ? 123 ILE A CA 1 ATOM 977 C C . ILE A 1 124 ? 47.479 142.391 -4.415 1.00 227.22 ? 123 ILE A C 1 ATOM 978 O O . ILE A 1 124 ? 48.408 141.902 -5.059 1.00 227.22 ? 123 ILE A O 1 ATOM 979 C CB . ILE A 1 124 ? 46.120 144.414 -5.060 1.00 227.22 ? 123 ILE A CB 1 ATOM 980 C CG1 . ILE A 1 124 ? 44.875 144.906 -5.804 1.00 227.22 ? 123 ILE A CG1 1 ATOM 981 C CG2 . ILE A 1 124 ? 47.382 145.053 -5.634 1.00 227.22 ? 123 ILE A CG2 1 ATOM 982 C CD1 . ILE A 1 124 ? 44.658 146.413 -5.777 1.00 227.22 ? 123 ILE A CD1 1 ATOM 983 N N . ALA A 1 125 ? 47.473 142.500 -3.083 1.00 227.22 ? 124 ALA A N 1 ATOM 984 C CA . ALA A 1 125 ? 48.556 142.014 -2.209 1.00 227.22 ? 124 ALA A CA 1 ATOM 985 C C . ALA A 1 125 ? 48.939 140.552 -2.468 1.00 227.22 ? 124 ALA A C 1 ATOM 986 O O . ALA A 1 125 ? 50.104 140.170 -2.305 1.00 227.22 ? 124 ALA A O 1 ATOM 987 C CB . ALA A 1 125 ? 48.185 142.221 -0.728 1.00 227.22 ? 124 ALA A CB 1 ATOM 988 N N . LEU A 1 126 ? 47.953 139.748 -2.873 1.00 227.22 ? 125 LEU A N 1 ATOM 989 C CA . LEU A 1 126 ? 48.175 138.348 -3.200 1.00 227.22 ? 125 LEU A CA 1 ATOM 990 C C . LEU A 1 126 ? 48.830 138.230 -4.563 1.00 227.22 ? 125 LEU A C 1 ATOM 991 O O . LEU A 1 126 ? 49.905 137.651 -4.680 1.00 227.22 ? 125 LEU A O 1 ATOM 992 C CB . LEU A 1 126 ? 46.862 137.568 -3.211 1.00 227.22 ? 125 LEU A CB 1 ATOM 993 C CG . LEU A 1 126 ? 46.862 136.088 -2.811 1.00 227.22 ? 125 LEU A CG 1 ATOM 994 C CD1 . LEU A 1 126 ? 45.759 135.384 -3.563 1.00 227.22 ? 125 LEU A CD1 1 ATOM 995 C CD2 . LEU A 1 126 ? 48.192 135.357 -3.013 1.00 227.22 ? 125 LEU A CD2 1 ATOM 996 N N . TRP A 1 127 ? 48.184 138.775 -5.592 1.00 227.22 ? 126 TRP A N 1 ATOM 997 C CA . TRP A 1 127 ? 48.696 138.645 -6.956 1.00 227.22 ? 126 TRP A CA 1 ATOM 998 C C . TRP A 1 127 ? 50.057 139.304 -7.135 1.00 227.22 ? 126 TRP A C 1 ATOM 999 O O . TRP A 1 127 ? 50.915 138.773 -7.832 1.00 227.22 ? 126 TRP A O 1 ATOM 1000 C CB . TRP A 1 127 ? 47.690 139.154 -7.990 1.00 227.22 ? 126 TRP A CB 1 ATOM 1001 C CG . TRP A 1 127 ? 46.494 138.254 -8.155 1.00 227.22 ? 126 TRP A CG 1 ATOM 1002 C CD1 . TRP A 1 127 ? 45.193 138.563 -7.882 1.00 227.22 ? 126 TRP A CD1 1 ATOM 1003 C CD2 . TRP A 1 127 ? 46.493 136.898 -8.617 1.00 227.22 ? 126 TRP A CD2 1 ATOM 1004 N NE1 . TRP A 1 127 ? 44.379 137.487 -8.150 1.00 227.22 ? 126 TRP A NE1 1 ATOM 1005 C CE2 . TRP A 1 127 ? 45.151 136.452 -8.602 1.00 227.22 ? 126 TRP A CE2 1 ATOM 1006 C CE3 . TRP A 1 127 ? 47.493 136.018 -9.046 1.00 227.22 ? 126 TRP A CE3 1 ATOM 1007 C CZ2 . TRP A 1 127 ? 44.783 135.167 -9.001 1.00 227.22 ? 126 TRP A CZ2 1 ATOM 1008 C CZ3 . TRP A 1 127 ? 47.129 134.740 -9.443 1.00 227.22 ? 126 TRP A CZ3 1 ATOM 1009 C CH2 . TRP A 1 127 ? 45.783 134.327 -9.419 1.00 227.22 ? 126 TRP A CH2 1 ATOM 1010 N N . SER A 1 128 ? 50.257 140.450 -6.492 1.00 227.22 ? 127 SER A N 1 ATOM 1011 C CA . SER A 1 128 ? 51.564 141.100 -6.506 1.00 227.22 ? 127 SER A CA 1 ATOM 1012 C C . SER A 1 128 ? 52.653 140.169 -5.980 1.00 227.22 ? 127 SER A C 1 ATOM 1013 O O . SER A 1 128 ? 53.732 140.085 -6.566 1.00 227.22 ? 127 SER A O 1 ATOM 1014 C CB . SER A 1 128 ? 51.540 142.419 -5.736 1.00 227.22 ? 127 SER A CB 1 ATOM 1015 O OG . SER A 1 128 ? 51.366 143.512 -6.621 1.00 227.22 ? 127 SER A OG 1 ATOM 1016 N N . LEU A 1 129 ? 52.356 139.456 -4.893 1.00 227.22 ? 128 LEU A N 1 ATOM 1017 C CA . LEU A 1 129 ? 53.251 138.423 -4.372 1.00 227.22 ? 128 LEU A CA 1 ATOM 1018 C C . LEU A 1 129 ? 53.553 137.384 -5.433 1.00 227.22 ? 128 LEU A C 1 ATOM 1019 O O . LEU A 1 129 ? 54.662 136.859 -5.497 1.00 227.22 ? 128 LEU A O 1 ATOM 1020 C CB . LEU A 1 129 ? 52.636 137.723 -3.165 1.00 227.22 ? 128 LEU A CB 1 ATOM 1021 C CG . LEU A 1 129 ? 52.725 138.382 -1.805 1.00 227.22 ? 128 LEU A CG 1 ATOM 1022 C CD1 . LEU A 1 129 ? 51.859 137.591 -0.867 1.00 227.22 ? 128 LEU A CD1 1 ATOM 1023 C CD2 . LEU A 1 129 ? 54.160 138.408 -1.329 1.00 227.22 ? 128 LEU A CD2 1 ATOM 1024 N N . VAL A 1 130 ? 52.552 137.086 -6.255 1.00 227.22 ? 129 VAL A N 1 ATOM 1025 C CA . VAL A 1 130 ? 52.703 136.115 -7.317 1.00 227.22 ? 129 VAL A CA 1 ATOM 1026 C C . VAL A 1 130 ? 53.783 136.615 -8.269 1.00 227.22 ? 129 VAL A C 1 ATOM 1027 O O . VAL A 1 130 ? 54.800 135.949 -8.452 1.00 227.22 ? 129 VAL A O 1 ATOM 1028 C CB . VAL A 1 130 ? 51.367 135.855 -8.042 1.00 227.22 ? 129 VAL A CB 1 ATOM 1029 C CG1 . VAL A 1 130 ? 51.568 134.935 -9.235 1.00 227.22 ? 129 VAL A CG1 1 ATOM 1030 C CG2 . VAL A 1 130 ? 50.352 135.259 -7.079 1.00 227.22 ? 129 VAL A CG2 1 ATOM 1031 N N . VAL A 1 131 ? 53.573 137.802 -8.833 1.00 227.22 ? 130 VAL A N 1 ATOM 1032 C CA . VAL A 1 131 ? 54.564 138.459 -9.691 1.00 227.22 ? 130 VAL A CA 1 ATOM 1033 C C . VAL A 1 131 ? 55.956 138.451 -9.049 1.00 227.22 ? 130 VAL A C 1 ATOM 1034 O O . VAL A 1 131 ? 56.937 138.051 -9.682 1.00 227.22 ? 130 VAL A O 1 ATOM 1035 C CB . VAL A 1 131 ? 54.124 139.908 -10.040 1.00 227.22 ? 130 VAL A CB 1 ATOM 1036 C CG1 . VAL A 1 131 ? 55.306 140.767 -10.471 1.00 227.22 ? 130 VAL A CG1 1 ATOM 1037 C CG2 . VAL A 1 131 ? 53.051 139.895 -11.119 1.00 227.22 ? 130 VAL A CG2 1 ATOM 1038 N N . LEU A 1 132 ? 56.015 138.877 -7.786 1.00 227.22 ? 131 LEU A N 1 ATOM 1039 C CA . LEU A 1 132 ? 57.250 138.913 -6.995 1.00 227.22 ? 131 LEU A CA 1 ATOM 1040 C C . LEU A 1 132 ? 57.968 137.567 -6.943 1.00 227.22 ? 131 LEU A C 1 ATOM 1041 O O . LEU A 1 132 ? 59.187 137.494 -7.121 1.00 227.22 ? 131 LEU A O 1 ATOM 1042 C CB . LEU A 1 132 ? 56.952 139.380 -5.565 1.00 227.22 ? 131 LEU A CB 1 ATOM 1043 C CG . LEU A 1 132 ? 56.723 140.870 -5.307 1.00 227.22 ? 131 LEU A CG 1 ATOM 1044 C CD1 . LEU A 1 132 ? 55.783 141.056 -4.134 1.00 227.22 ? 131 LEU A CD1 1 ATOM 1045 C CD2 . LEU A 1 132 ? 58.036 141.610 -5.066 1.00 227.22 ? 131 LEU A CD2 1 ATOM 1046 N N . ALA A 1 133 ? 57.204 136.507 -6.695 1.00 227.22 ? 132 ALA A N 1 ATOM 1047 C CA . ALA A 1 133 ? 57.753 135.162 -6.599 1.00 227.22 ? 132 ALA A CA 1 ATOM 1048 C C . ALA A 1 133 ? 58.489 134.777 -7.877 1.00 227.22 ? 132 ALA A C 1 ATOM 1049 O O . ALA A 1 133 ? 59.584 134.218 -7.811 1.00 227.22 ? 132 ALA A O 1 ATOM 1050 C CB . ALA A 1 133 ? 56.652 134.163 -6.281 1.00 227.22 ? 132 ALA A CB 1 ATOM 1051 N N . ILE A 1 134 ? 57.896 135.111 -9.027 1.00 227.22 ? 133 ILE A N 1 ATOM 1052 C CA . ILE A 1 134 ? 58.435 134.747 -10.345 1.00 227.22 ? 133 ILE A CA 1 ATOM 1053 C C . ILE A 1 134 ? 59.609 135.625 -10.798 1.00 227.22 ? 133 ILE A C 1 ATOM 1054 O O . ILE A 1 134 ? 60.516 135.150 -11.486 1.00 227.22 ? 133 ILE A O 1 ATOM 1055 C CB . ILE A 1 134 ? 57.350 134.766 -11.451 1.00 227.22 ? 133 ILE A CB 1 ATOM 1056 C CG1 . ILE A 1 134 ? 55.959 134.527 -10.868 1.00 227.22 ? 133 ILE A CG1 1 ATOM 1057 C CG2 . ILE A 1 134 ? 57.666 133.729 -12.524 1.00 227.22 ? 133 ILE A CG2 1 ATOM 1058 C CD1 . ILE A 1 134 ? 54.852 135.201 -11.651 1.00 227.22 ? 133 ILE A CD1 1 ATOM 1059 N N . GLU A 1 135 ? 59.581 136.904 -10.429 1.00 227.22 ? 134 GLU A N 1 ATOM 1060 C CA . GLU A 1 135 ? 60.672 137.818 -10.757 1.00 227.22 ? 134 GLU A CA 1 ATOM 1061 C C . GLU A 1 135 ? 61.973 137.312 -10.147 1.00 227.22 ? 134 GLU A C 1 ATOM 1062 O O . GLU A 1 135 ? 62.979 137.190 -10.846 1.00 227.22 ? 134 GLU A O 1 ATOM 1063 C CB . GLU A 1 135 ? 60.359 139.233 -10.268 1.00 227.22 ? 134 GLU A CB 1 ATOM 1064 C CG . GLU A 1 135 ? 61.305 140.306 -10.805 1.00 227.22 ? 134 GLU A CG 1 ATOM 1065 C CD . GLU A 1 135 ? 62.424 140.680 -9.839 1.00 227.22 ? 134 GLU A CD 1 ATOM 1066 O OE1 . GLU A 1 135 ? 62.160 140.802 -8.624 1.00 227.22 ? 134 GLU A OE1 1 ATOM 1067 O OE2 . GLU A 1 135 ? 63.567 140.886 -10.301 1.00 227.22 ? 134 GLU A OE2 1 ATOM 1068 N N . ARG A 1 136 ? 61.925 137.006 -8.847 1.00 227.22 ? 135 ARG A N 1 ATOM 1069 C CA . ARG A 1 136 ? 63.053 136.426 -8.100 1.00 227.22 ? 135 ARG A CA 1 ATOM 1070 C C . ARG A 1 136 ? 63.458 135.087 -8.685 1.00 227.22 ? 135 ARG A C 1 ATOM 1071 O O . ARG A 1 136 ? 64.633 134.710 -8.669 1.00 227.22 ? 135 ARG A O 1 ATOM 1072 C CB . ARG A 1 136 ? 62.696 136.230 -6.623 1.00 227.22 ? 135 ARG A CB 1 ATOM 1073 C CG . ARG A 1 136 ? 62.308 137.492 -5.880 1.00 227.22 ? 135 ARG A CG 1 ATOM 1074 C CD . ARG A 1 136 ? 63.245 138.642 -6.177 1.00 227.22 ? 135 ARG A CD 1 ATOM 1075 N NE . ARG A 1 136 ? 64.642 138.237 -6.102 1.00 227.22 ? 135 ARG A NE 1 ATOM 1076 C CZ . ARG A 1 136 ? 65.649 138.935 -6.612 1.00 227.22 ? 135 ARG A CZ 1 ATOM 1077 N NH1 . ARG A 1 136 ? 65.422 140.080 -7.242 1.00 227.22 ? 135 ARG A NH1 1 ATOM 1078 N NH2 . ARG A 1 136 ? 66.889 138.487 -6.489 1.00 227.22 ? 135 ARG A NH2 1 ATOM 1079 N N . TYR A 1 137 ? 62.459 134.367 -9.184 1.00 227.22 ? 136 TYR A N 1 ATOM 1080 C CA . TYR A 1 137 ? 62.674 133.128 -9.885 1.00 227.22 ? 136 TYR A CA 1 ATOM 1081 C C . TYR A 1 137 ? 63.510 133.420 -11.120 1.00 227.22 ? 136 TYR A C 1 ATOM 1082 O O . TYR A 1 137 ? 64.616 132.906 -11.240 1.00 227.22 ? 136 TYR A O 1 ATOM 1083 C CB . TYR A 1 137 ? 61.329 132.492 -10.231 1.00 227.22 ? 136 TYR A CB 1 ATOM 1084 C CG . TYR A 1 137 ? 61.404 131.285 -11.121 1.00 227.22 ? 136 TYR A CG 1 ATOM 1085 C CD1 . TYR A 1 137 ? 62.146 130.165 -10.751 1.00 227.22 ? 136 TYR A CD1 1 ATOM 1086 C CD2 . TYR A 1 137 ? 60.709 131.248 -12.328 1.00 227.22 ? 136 TYR A CD2 1 ATOM 1087 C CE1 . TYR A 1 137 ? 62.218 129.045 -11.573 1.00 227.22 ? 136 TYR A CE1 1 ATOM 1088 C CE2 . TYR A 1 137 ? 60.766 130.127 -13.159 1.00 227.22 ? 136 TYR A CE2 1 ATOM 1089 C CZ . TYR A 1 137 ? 61.522 129.027 -12.773 1.00 227.22 ? 136 TYR A CZ 1 ATOM 1090 O OH . TYR A 1 137 ? 61.588 127.913 -13.587 1.00 227.22 ? 136 TYR A OH 1 ATOM 1091 N N . VAL A 1 138 ? 63.008 134.287 -12.000 1.00 227.22 ? 137 VAL A N 1 ATOM 1092 C CA . VAL A 1 138 ? 63.710 134.630 -13.253 1.00 227.22 ? 137 VAL A CA 1 ATOM 1093 C C . VAL A 1 138 ? 65.110 135.242 -13.025 1.00 227.22 ? 137 VAL A C 1 ATOM 1094 O O . VAL A 1 138 ? 66.053 134.918 -13.754 1.00 227.22 ? 137 VAL A O 1 ATOM 1095 C CB . VAL A 1 138 ? 62.831 135.521 -14.218 1.00 227.22 ? 137 VAL A CB 1 ATOM 1096 C CG1 . VAL A 1 138 ? 63.638 136.025 -15.430 1.00 227.22 ? 137 VAL A CG1 1 ATOM 1097 C CG2 . VAL A 1 138 ? 61.592 134.760 -14.691 1.00 227.22 ? 137 VAL A CG2 1 ATOM 1098 N N . VAL A 1 139 ? 65.244 136.106 -12.015 1.00 227.22 ? 138 VAL A N 1 ATOM 1099 C CA . VAL A 1 139 ? 66.506 136.831 -11.785 1.00 227.22 ? 138 VAL A CA 1 ATOM 1100 C C . VAL A 1 139 ? 67.561 135.996 -11.040 1.00 227.22 ? 138 VAL A C 1 ATOM 1101 O O . VAL A 1 139 ? 68.762 136.238 -11.188 1.00 227.22 ? 138 VAL A O 1 ATOM 1102 C CB . VAL A 1 139 ? 66.283 138.223 -11.105 1.00 227.22 ? 138 VAL A CB 1 ATOM 1103 C CG1 . VAL A 1 139 ? 67.596 138.987 -10.959 1.00 227.22 ? 138 VAL A CG1 1 ATOM 1104 C CG2 . VAL A 1 139 ? 65.318 139.059 -11.913 1.00 227.22 ? 138 VAL A CG2 1 ATOM 1105 N N . VAL A 1 140 ? 67.120 135.008 -10.260 1.00 227.22 ? 139 VAL A N 1 ATOM 1106 C CA . VAL A 1 140 ? 68.050 134.176 -9.484 1.00 227.22 ? 139 VAL A CA 1 ATOM 1107 C C . VAL A 1 140 ? 68.209 132.775 -10.070 1.00 227.22 ? 139 VAL A C 1 ATOM 1108 O O . VAL A 1 140 ? 69.325 132.254 -10.137 1.00 227.22 ? 139 VAL A O 1 ATOM 1109 C CB . VAL A 1 140 ? 67.665 134.099 -7.982 1.00 227.22 ? 139 VAL A CB 1 ATOM 1110 C CG1 . VAL A 1 140 ? 68.588 133.142 -7.228 1.00 227.22 ? 139 VAL A CG1 1 ATOM 1111 C CG2 . VAL A 1 140 ? 67.720 135.483 -7.343 1.00 227.22 ? 139 VAL A CG2 1 ATOM 1112 N N . CYS A 1 141 ? 67.099 132.164 -10.481 1.00 227.22 ? 140 CYS A N 1 ATOM 1113 C CA . CYS A 1 141 ? 67.155 130.871 -11.168 1.00 227.22 ? 140 CYS A CA 1 ATOM 1114 C C . CYS A 1 141 ? 67.497 131.078 -12.638 1.00 227.22 ? 140 CYS A C 1 ATOM 1115 O O . CYS A 1 141 ? 67.954 130.146 -13.308 1.00 227.22 ? 140 CYS A O 1 ATOM 1116 C CB . CYS A 1 141 ? 65.831 130.110 -11.055 1.00 227.22 ? 140 CYS A CB 1 ATOM 1117 S SG . CYS A 1 141 ? 64.954 130.317 -9.500 1.00 227.22 ? 140 CYS A SG 1 ATOM 1118 N N . LYS A 1 142 ? 67.267 132.304 -13.120 1.00 227.22 ? 141 LYS A N 1 ATOM 1119 C CA . LYS A 1 142 ? 67.500 132.693 -14.518 1.00 227.22 ? 141 LYS A CA 1 ATOM 1120 C C . LYS A 1 142 ? 67.359 131.518 -15.509 1.00 227.22 ? 141 LYS A C 1 ATOM 1121 O O . LYS A 1 142 ? 68.312 131.176 -16.224 1.00 227.22 ? 141 LYS A O 1 ATOM 1122 C CB . LYS A 1 142 ? 68.829 133.472 -14.666 1.00 227.22 ? 141 LYS A CB 1 ATOM 1123 C CG . LYS A 1 142 ? 69.913 133.172 -13.614 1.00 227.22 ? 141 LYS A CG 1 ATOM 1124 C CD . LYS A 1 142 ? 70.644 134.443 -13.159 1.00 227.22 ? 141 LYS A CD 1 ATOM 1125 C CE . LYS A 1 142 ? 71.911 134.745 -13.965 1.00 227.22 ? 141 LYS A CE 1 ATOM 1126 N NZ . LYS A 1 142 ? 73.068 133.871 -13.585 1.00 227.22 ? 141 LYS A NZ 1 ATOM 1127 N N . PRO A 1 143 ? 66.149 130.910 -15.560 1.00 227.22 ? 142 PRO A N 1 ATOM 1128 C CA . PRO A 1 143 ? 65.966 129.588 -16.181 1.00 227.22 ? 142 PRO A CA 1 ATOM 1129 C C . PRO A 1 143 ? 65.778 129.605 -17.709 1.00 227.22 ? 142 PRO A C 1 ATOM 1130 O O . PRO A 1 143 ? 66.257 128.692 -18.394 1.00 227.22 ? 142 PRO A O 1 ATOM 1131 C CB . PRO A 1 143 ? 64.718 129.044 -15.477 1.00 227.22 ? 142 PRO A CB 1 ATOM 1132 C CG . PRO A 1 143 ? 63.929 130.277 -15.087 1.00 227.22 ? 142 PRO A CG 1 ATOM 1133 C CD . PRO A 1 143 ? 64.872 131.461 -15.058 1.00 227.22 ? 142 PRO A CD 1 ATOM 1134 N N . MET A 1 144 ? 65.083 130.627 -18.220 1.00 227.22 ? 143 MET A N 1 ATOM 1135 C CA . MET A 1 144 ? 64.907 130.845 -19.656 1.00 227.22 ? 143 MET A CA 1 ATOM 1136 C C . MET A 1 144 ? 66.202 131.426 -20.232 1.00 227.22 ? 143 MET A C 1 ATOM 1137 O O . MET A 1 144 ? 67.133 131.762 -19.479 1.00 227.22 ? 143 MET A O 1 ATOM 1138 C CB . MET A 1 144 ? 63.725 131.797 -19.905 1.00 227.22 ? 143 MET A CB 1 ATOM 1139 C CG . MET A 1 144 ? 63.086 131.723 -21.300 1.00 227.22 ? 143 MET A CG 1 ATOM 1140 S SD . MET A 1 144 ? 61.982 130.311 -21.574 1.00 227.22 ? 143 MET A SD 1 ATOM 1141 C CE . MET A 1 144 ? 63.096 129.115 -22.324 1.00 227.22 ? 143 MET A CE 1 ATOM 1142 N N . SER A 1 145 ? 66.255 131.537 -21.562 1.00 227.22 ? 144 SER A N 1 ATOM 1143 C CA . SER A 1 145 ? 67.431 132.039 -22.287 1.00 227.22 ? 144 SER A CA 1 ATOM 1144 C C . SER A 1 145 ? 67.758 133.503 -21.943 1.00 227.22 ? 144 SER A C 1 ATOM 1145 O O . SER A 1 145 ? 67.071 134.123 -21.117 1.00 227.22 ? 144 SER A O 1 ATOM 1146 C CB . SER A 1 145 ? 67.215 131.877 -23.799 1.00 227.22 ? 144 SER A CB 1 ATOM 1147 O OG . SER A 1 145 ? 66.681 130.597 -24.111 1.00 227.22 ? 144 SER A OG 1 ATOM 1148 N N . ASN A 1 146 ? 68.809 134.040 -22.572 1.00 227.22 ? 145 ASN A N 1 ATOM 1149 C CA . ASN A 1 146 ? 69.207 135.440 -22.397 1.00 227.22 ? 145 ASN A CA 1 ATOM 1150 C C . ASN A 1 146 ? 67.995 136.395 -22.413 1.00 227.22 ? 145 ASN A C 1 ATOM 1151 O O . ASN A 1 146 ? 67.422 136.672 -23.475 1.00 227.22 ? 145 ASN A O 1 ATOM 1152 C CB . ASN A 1 146 ? 70.219 135.830 -23.481 1.00 227.22 ? 145 ASN A CB 1 ATOM 1153 C CG . ASN A 1 146 ? 71.484 136.440 -22.912 1.00 227.22 ? 145 ASN A CG 1 ATOM 1154 O OD1 . ASN A 1 146 ? 71.705 137.653 -23.024 1.00 227.22 ? 145 ASN A OD1 1 ATOM 1155 N ND2 . ASN A 1 146 ? 72.332 135.594 -22.309 1.00 227.22 ? 145 ASN A ND2 1 ATOM 1156 N N . PHE A 1 147 ? 67.611 136.874 -21.226 1.00 227.22 ? 146 PHE A N 1 ATOM 1157 C CA . PHE A 1 147 ? 66.397 137.685 -21.035 1.00 227.22 ? 146 PHE A CA 1 ATOM 1158 C C . PHE A 1 147 ? 66.655 138.845 -20.058 1.00 227.22 ? 146 PHE A C 1 ATOM 1159 O O . PHE A 1 147 ? 67.664 138.861 -19.343 1.00 227.22 ? 146 PHE A O 1 ATOM 1160 C CB . PHE A 1 147 ? 65.233 136.772 -20.579 1.00 227.22 ? 146 PHE A CB 1 ATOM 1161 C CG . PHE A 1 147 ? 63.875 137.451 -20.488 1.00 227.22 ? 146 PHE A CG 1 ATOM 1162 C CD1 . PHE A 1 147 ? 63.525 138.518 -21.323 1.00 227.22 ? 146 PHE A CD1 1 ATOM 1163 C CD2 . PHE A 1 147 ? 62.925 136.980 -19.584 1.00 227.22 ? 146 PHE A CD2 1 ATOM 1164 C CE1 . PHE A 1 147 ? 62.265 139.128 -21.225 1.00 227.22 ? 146 PHE A CE1 1 ATOM 1165 C CE2 . PHE A 1 147 ? 61.662 137.577 -19.486 1.00 227.22 ? 146 PHE A CE2 1 ATOM 1166 C CZ . PHE A 1 147 ? 61.335 138.649 -20.309 1.00 227.22 ? 146 PHE A CZ 1 ATOM 1167 N N . ARG A 1 148 ? 65.764 139.832 -20.073 1.00 227.22 ? 147 ARG A N 1 ATOM 1168 C CA . ARG A 1 148 ? 65.779 140.907 -19.092 1.00 227.22 ? 147 ARG A CA 1 ATOM 1169 C C . ARG A 1 148 ? 64.383 141.119 -18.480 1.00 227.22 ? 147 ARG A C 1 ATOM 1170 O O . ARG A 1 148 ? 63.408 141.391 -19.204 1.00 227.22 ? 147 ARG A O 1 ATOM 1171 C CB . ARG A 1 148 ? 66.346 142.213 -19.688 1.00 227.22 ? 147 ARG A CB 1 ATOM 1172 C CG . ARG A 1 148 ? 65.439 142.911 -20.712 1.00 227.22 ? 147 ARG A CG 1 ATOM 1173 C CD . ARG A 1 148 ? 66.142 144.050 -21.455 1.00 227.22 ? 147 ARG A CD 1 ATOM 1174 N NE . ARG A 1 148 ? 65.497 144.331 -22.743 1.00 227.22 ? 147 ARG A NE 1 ATOM 1175 C CZ . ARG A 1 148 ? 65.808 143.740 -23.901 1.00 227.22 ? 147 ARG A CZ 1 ATOM 1176 N NH1 . ARG A 1 148 ? 66.774 142.823 -23.962 1.00 227.22 ? 147 ARG A NH1 1 ATOM 1177 N NH2 . ARG A 1 148 ? 65.151 144.067 -25.012 1.00 227.22 ? 147 ARG A NH2 1 ATOM 1178 N N . PHE A 1 149 ? 64.293 140.937 -17.156 1.00 227.22 ? 148 PHE A N 1 ATOM 1179 C CA . PHE A 1 149 ? 63.173 141.464 -16.378 1.00 227.22 ? 148 PHE A CA 1 ATOM 1180 C C . PHE A 1 149 ? 63.580 142.894 -16.004 1.00 227.22 ? 148 PHE A C 1 ATOM 1181 O O . PHE A 1 149 ? 64.326 143.111 -15.036 1.00 227.22 ? 148 PHE A O 1 ATOM 1182 C CB . PHE A 1 149 ? 62.872 140.607 -15.131 1.00 227.22 ? 148 PHE A CB 1 ATOM 1183 C CG . PHE A 1 149 ? 61.424 140.689 -14.655 1.00 227.22 ? 148 PHE A CG 1 ATOM 1184 C CD1 . PHE A 1 149 ? 60.929 141.844 -14.031 1.00 227.22 ? 148 PHE A CD1 1 ATOM 1185 C CD2 . PHE A 1 149 ? 60.559 139.602 -14.822 1.00 227.22 ? 148 PHE A CD2 1 ATOM 1186 C CE1 . PHE A 1 149 ? 59.598 141.916 -13.601 1.00 227.22 ? 148 PHE A CE1 1 ATOM 1187 C CE2 . PHE A 1 149 ? 59.225 139.666 -14.388 1.00 227.22 ? 148 PHE A CE2 1 ATOM 1188 C CZ . PHE A 1 149 ? 58.747 140.824 -13.779 1.00 227.22 ? 148 PHE A CZ 1 ATOM 1189 N N . GLY A 1 150 ? 63.124 143.853 -16.815 1.00 227.22 ? 149 GLY A N 1 ATOM 1190 C CA . GLY A 1 150 ? 63.433 145.270 -16.631 1.00 227.22 ? 149 GLY A CA 1 ATOM 1191 C C . GLY A 1 150 ? 62.186 146.116 -16.447 1.00 227.22 ? 149 GLY A C 1 ATOM 1192 O O . GLY A 1 150 ? 61.148 145.616 -16.006 1.00 227.22 ? 149 GLY A O 1 ATOM 1193 N N . GLU A 1 151 ? 62.298 147.397 -16.801 1.00 227.22 ? 150 GLU A N 1 ATOM 1194 C CA . GLU A 1 151 ? 61.220 148.390 -16.643 1.00 227.22 ? 150 GLU A CA 1 ATOM 1195 C C . GLU A 1 151 ? 59.859 147.993 -17.236 1.00 227.22 ? 150 GLU A C 1 ATOM 1196 O O . GLU A 1 151 ? 58.813 148.335 -16.677 1.00 227.22 ? 150 GLU A O 1 ATOM 1197 C CB . GLU A 1 151 ? 61.633 149.736 -17.254 1.00 227.22 ? 150 GLU A CB 1 ATOM 1198 C CG . GLU A 1 151 ? 62.741 150.479 -16.527 1.00 227.22 ? 150 GLU A CG 1 ATOM 1199 C CD . GLU A 1 151 ? 62.822 151.945 -16.934 1.00 227.22 ? 150 GLU A CD 1 ATOM 1200 O OE1 . GLU A 1 151 ? 61.774 152.633 -16.920 1.00 227.22 ? 150 GLU A OE1 1 ATOM 1201 O OE2 . GLU A 1 151 ? 63.937 152.411 -17.261 1.00 227.22 ? 150 GLU A OE2 1 ATOM 1202 N N . ASN A 1 152 ? 59.889 147.284 -18.367 1.00 227.22 ? 151 ASN A N 1 ATOM 1203 C CA . ASN A 1 152 ? 58.692 146.991 -19.174 1.00 227.22 ? 151 ASN A CA 1 ATOM 1204 C C . ASN A 1 152 ? 57.745 145.976 -18.533 1.00 227.22 ? 151 ASN A C 1 ATOM 1205 O O . ASN A 1 152 ? 56.519 146.136 -18.584 1.00 227.22 ? 151 ASN A O 1 ATOM 1206 C CB . ASN A 1 152 ? 59.091 146.519 -20.584 1.00 227.22 ? 151 ASN A CB 1 ATOM 1207 C CG . ASN A 1 152 ? 60.081 147.457 -21.264 1.00 227.22 ? 151 ASN A CG 1 ATOM 1208 O OD1 . ASN A 1 152 ? 59.841 148.661 -21.386 1.00 227.22 ? 151 ASN A OD1 1 ATOM 1209 N ND2 . ASN A 1 152 ? 61.203 146.901 -21.713 1.00 227.22 ? 151 ASN A ND2 1 ATOM 1210 N N . HIS A 1 153 ? 58.326 144.934 -17.941 1.00 227.22 ? 152 HIS A N 1 ATOM 1211 C CA . HIS A 1 153 ? 57.564 143.877 -17.276 1.00 227.22 ? 152 HIS A CA 1 ATOM 1212 C C . HIS A 1 153 ? 56.994 144.344 -15.939 1.00 227.22 ? 152 HIS A C 1 ATOM 1213 O O . HIS A 1 153 ? 55.924 143.884 -15.515 1.00 227.22 ? 152 HIS A O 1 ATOM 1214 C CB . HIS A 1 153 ? 58.449 142.657 -17.043 1.00 227.22 ? 152 HIS A CB 1 ATOM 1215 C CG . HIS A 1 153 ? 59.047 142.103 -18.293 1.00 227.22 ? 152 HIS A CG 1 ATOM 1216 N ND1 . HIS A 1 153 ? 60.190 142.622 -18.865 1.00 227.22 ? 152 HIS A ND1 1 ATOM 1217 C CD2 . HIS A 1 153 ? 58.663 141.072 -19.079 1.00 227.22 ? 152 HIS A CD2 1 ATOM 1218 C CE1 . HIS A 1 153 ? 60.479 141.937 -19.957 1.00 227.22 ? 152 HIS A CE1 1 ATOM 1219 N NE2 . HIS A 1 153 ? 59.568 140.991 -20.109 1.00 227.22 ? 152 HIS A NE2 1 ATOM 1220 N N . ALA A 1 154 ? 57.726 145.246 -15.280 1.00 227.22 ? 153 ALA A N 1 ATOM 1221 C CA . ALA A 1 154 ? 57.305 145.845 -14.013 1.00 227.22 ? 153 ALA A CA 1 ATOM 1222 C C . ALA A 1 154 ? 55.988 146.630 -14.139 1.00 227.22 ? 153 ALA A C 1 ATOM 1223 O O . ALA A 1 154 ? 55.309 146.850 -13.128 1.00 227.22 ? 153 ALA A O 1 ATOM 1224 C CB . ALA A 1 154 ? 58.415 146.724 -13.438 1.00 227.22 ? 153 ALA A CB 1 ATOM 1225 N N . ILE A 1 155 ? 55.634 147.038 -15.367 1.00 227.22 ? 154 ILE A N 1 ATOM 1226 C CA . ILE A 1 155 ? 54.327 147.659 -15.652 1.00 227.22 ? 154 ILE A CA 1 ATOM 1227 C C . ILE A 1 155 ? 53.323 146.633 -16.177 1.00 227.22 ? 154 ILE A C 1 ATOM 1228 O O . ILE A 1 155 ? 52.113 146.852 -16.122 1.00 227.22 ? 154 ILE A O 1 ATOM 1229 C CB . ILE A 1 155 ? 54.402 148.839 -16.666 1.00 227.22 ? 154 ILE A CB 1 ATOM 1230 C CG1 . ILE A 1 155 ? 55.802 149.480 -16.707 1.00 227.22 ? 154 ILE A CG1 1 ATOM 1231 C CG2 . ILE A 1 155 ? 53.269 149.852 -16.398 1.00 227.22 ? 154 ILE A CG2 1 ATOM 1232 C CD1 . ILE A 1 155 ? 56.089 150.512 -15.628 1.00 227.22 ? 154 ILE A CD1 1 ATOM 1233 N N . MET A 1 156 ? 53.830 145.519 -16.697 1.00 227.22 ? 155 MET A N 1 ATOM 1234 C CA . MET A 1 156 ? 52.977 144.411 -17.113 1.00 227.22 ? 155 MET A CA 1 ATOM 1235 C C . MET A 1 156 ? 52.450 143.690 -15.878 1.00 227.22 ? 155 MET A C 1 ATOM 1236 O O . MET A 1 156 ? 51.332 143.171 -15.883 1.00 227.22 ? 155 MET A O 1 ATOM 1237 C CB . MET A 1 156 ? 53.741 143.431 -18.022 1.00 227.22 ? 155 MET A CB 1 ATOM 1238 C CG . MET A 1 156 ? 54.037 143.935 -19.458 1.00 227.22 ? 155 MET A CG 1 ATOM 1239 S SD . MET A 1 156 ? 52.650 143.906 -20.636 1.00 227.22 ? 155 MET A SD 1 ATOM 1240 C CE . MET A 1 156 ? 52.370 142.141 -20.826 1.00 227.22 ? 155 MET A CE 1 ATOM 1241 N N . GLY A 1 157 ? 53.268 143.693 -14.824 1.00 227.22 ? 156 GLY A N 1 ATOM 1242 C CA . GLY A 1 157 ? 52.991 142.999 -13.557 1.00 227.22 ? 156 GLY A CA 1 ATOM 1243 C C . GLY A 1 157 ? 52.061 143.706 -12.581 1.00 227.22 ? 156 GLY A C 1 ATOM 1244 O O . GLY A 1 157 ? 51.155 143.078 -12.024 1.00 227.22 ? 156 GLY A O 1 ATOM 1245 N N . VAL A 1 158 ? 52.299 145.001 -12.358 1.00 227.22 ? 157 VAL A N 1 ATOM 1246 C CA . VAL A 1 158 ? 51.368 145.859 -11.613 1.00 227.22 ? 157 VAL A CA 1 ATOM 1247 C C . VAL A 1 158 ? 49.983 145.816 -12.268 1.00 227.22 ? 157 VAL A C 1 ATOM 1248 O O . VAL A 1 158 ? 48.965 145.763 -11.575 1.00 227.22 ? 157 VAL A O 1 ATOM 1249 C CB . VAL A 1 158 ? 51.877 147.327 -11.530 1.00 227.22 ? 157 VAL A CB 1 ATOM 1250 C CG1 . VAL A 1 158 ? 50.830 148.246 -10.903 1.00 227.22 ? 157 VAL A CG1 1 ATOM 1251 C CG2 . VAL A 1 158 ? 53.179 147.401 -10.751 1.00 227.22 ? 157 VAL A CG2 1 ATOM 1252 N N . ALA A 1 159 ? 49.969 145.818 -13.604 1.00 227.22 ? 158 ALA A N 1 ATOM 1253 C CA . ALA A 1 159 ? 48.743 145.771 -14.418 1.00 227.22 ? 158 ALA A CA 1 ATOM 1254 C C . ALA A 1 159 ? 48.057 144.399 -14.413 1.00 227.22 ? 158 ALA A C 1 ATOM 1255 O O . ALA A 1 159 ? 46.852 144.300 -14.662 1.00 227.22 ? 158 ALA A O 1 ATOM 1256 C CB . ALA A 1 159 ? 49.039 146.207 -15.852 1.00 227.22 ? 158 ALA A CB 1 ATOM 1257 N N . PHE A 1 160 ? 48.830 143.352 -14.137 1.00 227.22 ? 159 PHE A N 1 ATOM 1258 C CA . PHE A 1 160 ? 48.299 141.998 -14.002 1.00 227.22 ? 159 PHE A CA 1 ATOM 1259 C C . PHE A 1 160 ? 47.574 141.799 -12.671 1.00 227.22 ? 159 PHE A C 1 ATOM 1260 O O . PHE A 1 160 ? 46.561 141.093 -12.609 1.00 227.22 ? 159 PHE A O 1 ATOM 1261 C CB . PHE A 1 160 ? 49.433 140.982 -14.158 1.00 227.22 ? 159 PHE A CB 1 ATOM 1262 C CG . PHE A 1 160 ? 49.136 139.630 -13.571 1.00 227.22 ? 159 PHE A CG 1 ATOM 1263 C CD1 . PHE A 1 160 ? 48.133 138.820 -14.101 1.00 227.22 ? 159 PHE A CD1 1 ATOM 1264 C CD2 . PHE A 1 160 ? 49.877 139.157 -12.497 1.00 227.22 ? 159 PHE A CD2 1 ATOM 1265 C CE1 . PHE A 1 160 ? 47.864 137.563 -13.561 1.00 227.22 ? 159 PHE A CE1 1 ATOM 1266 C CE2 . PHE A 1 160 ? 49.619 137.900 -11.952 1.00 227.22 ? 159 PHE A CE2 1 ATOM 1267 C CZ . PHE A 1 160 ? 48.607 137.102 -12.485 1.00 227.22 ? 159 PHE A CZ 1 ATOM 1268 N N . THR A 1 161 ? 48.104 142.426 -11.619 1.00 227.22 ? 160 THR A N 1 ATOM 1269 C CA . THR A 1 161 ? 47.597 142.274 -10.249 1.00 227.22 ? 160 THR A CA 1 ATOM 1270 C C . THR A 1 161 ? 46.247 142.951 -10.027 1.00 227.22 ? 160 THR A C 1 ATOM 1271 O O . THR A 1 161 ? 45.350 142.360 -9.421 1.00 227.22 ? 160 THR A O 1 ATOM 1272 C CB . THR A 1 161 ? 48.602 142.807 -9.217 1.00 227.22 ? 160 THR A CB 1 ATOM 1273 O OG1 . THR A 1 161 ? 48.837 144.199 -9.460 1.00 227.22 ? 160 THR A OG1 1 ATOM 1274 C CG2 . THR A 1 161 ? 49.909 142.053 -9.323 1.00 227.22 ? 160 THR A CG2 1 ATOM 1275 N N . TRP A 1 162 ? 46.120 144.189 -10.506 1.00 227.22 ? 161 TRP A N 1 ATOM 1276 C CA . TRP A 1 162 ? 44.841 144.901 -10.529 1.00 227.22 ? 161 TRP A CA 1 ATOM 1277 C C . TRP A 1 162 ? 43.789 144.094 -11.280 1.00 227.22 ? 161 TRP A C 1 ATOM 1278 O O . TRP A 1 162 ? 42.641 143.985 -10.839 1.00 227.22 ? 161 TRP A O 1 ATOM 1279 C CB . TRP A 1 162 ? 44.997 146.255 -11.214 1.00 227.22 ? 161 TRP A CB 1 ATOM 1280 C CG . TRP A 1 162 ? 45.555 147.314 -10.346 1.00 227.22 ? 161 TRP A CG 1 ATOM 1281 C CD1 . TRP A 1 162 ? 46.847 147.432 -9.921 1.00 227.22 ? 161 TRP A CD1 1 ATOM 1282 C CD2 . TRP A 1 162 ? 44.847 148.432 -9.801 1.00 227.22 ? 161 TRP A CD2 1 ATOM 1283 N NE1 . TRP A 1 162 ? 46.990 148.553 -9.137 1.00 227.22 ? 161 TRP A NE1 1 ATOM 1284 C CE2 . TRP A 1 162 ? 45.777 149.186 -9.046 1.00 227.22 ? 161 TRP A CE2 1 ATOM 1285 C CE3 . TRP A 1 162 ? 43.517 148.871 -9.874 1.00 227.22 ? 161 TRP A CE3 1 ATOM 1286 C CZ2 . TRP A 1 162 ? 45.419 150.359 -8.367 1.00 227.22 ? 161 TRP A CZ2 1 ATOM 1287 C CZ3 . TRP A 1 162 ? 43.159 150.040 -9.196 1.00 227.22 ? 161 TRP A CZ3 1 ATOM 1288 C CH2 . TRP A 1 162 ? 44.108 150.768 -8.452 1.00 227.22 ? 161 TRP A CH2 1 ATOM 1289 N N . VAL A 1 163 ? 44.209 143.539 -12.418 1.00 227.22 ? 162 VAL A N 1 ATOM 1290 C CA . VAL A 1 163 ? 43.383 142.717 -13.310 1.00 227.22 ? 162 VAL A CA 1 ATOM 1291 C C . VAL A 1 163 ? 42.718 141.518 -12.623 1.00 227.22 ? 162 VAL A C 1 ATOM 1292 O O . VAL A 1 163 ? 41.569 141.161 -12.919 1.00 227.22 ? 162 VAL A O 1 ATOM 1293 C CB . VAL A 1 163 ? 44.245 142.253 -14.511 1.00 227.22 ? 162 VAL A CB 1 ATOM 1294 C CG1 . VAL A 1 163 ? 43.956 140.807 -14.908 1.00 227.22 ? 162 VAL A CG1 1 ATOM 1295 C CG2 . VAL A 1 163 ? 44.073 143.214 -15.681 1.00 227.22 ? 162 VAL A CG2 1 ATOM 1296 N N . MET A 1 164 ? 43.451 140.922 -11.690 1.00 227.22 ? 163 MET A N 1 ATOM 1297 C CA . MET A 1 164 ? 43.032 139.701 -11.018 1.00 227.22 ? 163 MET A CA 1 ATOM 1298 C C . MET A 1 164 ? 42.562 139.944 -9.566 1.00 227.22 ? 163 MET A C 1 ATOM 1299 O O . MET A 1 164 ? 42.151 139.013 -8.864 1.00 227.22 ? 163 MET A O 1 ATOM 1300 C CB . MET A 1 164 ? 44.165 138.671 -11.100 1.00 227.22 ? 163 MET A CB 1 ATOM 1301 C CG . MET A 1 164 ? 44.607 138.318 -12.526 1.00 227.22 ? 163 MET A CG 1 ATOM 1302 S SD . MET A 1 164 ? 43.936 136.764 -13.142 1.00 227.22 ? 163 MET A SD 1 ATOM 1303 C CE . MET A 1 164 ? 42.206 137.171 -13.358 1.00 227.22 ? 163 MET A CE 1 ATOM 1304 N N . ALA A 1 165 ? 42.629 141.201 -9.132 1.00 227.22 ? 164 ALA A N 1 ATOM 1305 C CA . ALA A 1 165 ? 41.972 141.635 -7.903 1.00 227.22 ? 164 ALA A CA 1 ATOM 1306 C C . ALA A 1 165 ? 40.589 142.212 -8.224 1.00 227.22 ? 164 ALA A C 1 ATOM 1307 O O . ALA A 1 165 ? 39.655 142.093 -7.422 1.00 227.22 ? 164 ALA A O 1 ATOM 1308 C CB . ALA A 1 165 ? 42.821 142.649 -7.171 1.00 227.22 ? 164 ALA A CB 1 ATOM 1309 N N . LEU A 1 166 ? 40.475 142.837 -9.398 1.00 227.22 ? 165 LEU A N 1 ATOM 1310 C CA . LEU A 1 166 ? 39.194 143.299 -9.940 1.00 227.22 ? 165 LEU A CA 1 ATOM 1311 C C . LEU A 1 166 ? 38.372 142.122 -10.464 1.00 227.22 ? 165 LEU A C 1 ATOM 1312 O O . LEU A 1 166 ? 37.140 142.184 -10.539 1.00 227.22 ? 165 LEU A O 1 ATOM 1313 C CB . LEU A 1 166 ? 39.421 144.333 -11.048 1.00 227.22 ? 165 LEU A CB 1 ATOM 1314 C CG . LEU A 1 166 ? 39.432 145.811 -10.637 1.00 227.22 ? 165 LEU A CG 1 ATOM 1315 C CD1 . LEU A 1 166 ? 40.541 146.600 -11.331 1.00 227.22 ? 165 LEU A CD1 1 ATOM 1316 C CD2 . LEU A 1 166 ? 38.067 146.456 -10.881 1.00 227.22 ? 165 LEU A CD2 1 ATOM 1317 N N . ALA A 1 167 ? 39.073 141.048 -10.818 1.00 227.22 ? 166 ALA A N 1 ATOM 1318 C CA . ALA A 1 167 ? 38.439 139.795 -11.200 1.00 227.22 ? 166 ALA A CA 1 ATOM 1319 C C . ALA A 1 167 ? 37.738 139.137 -10.013 1.00 227.22 ? 166 ALA A C 1 ATOM 1320 O O . ALA A 1 167 ? 36.793 138.376 -10.202 1.00 227.22 ? 166 ALA A O 1 ATOM 1321 C CB . ALA A 1 167 ? 39.459 138.850 -11.800 1.00 227.22 ? 166 ALA A CB 1 ATOM 1322 N N . CYS A 1 168 ? 38.207 139.430 -8.800 1.00 227.22 ? 167 CYS A N 1 ATOM 1323 C CA . CYS A 1 168 ? 37.618 138.873 -7.579 1.00 227.22 ? 167 CYS A CA 1 ATOM 1324 C C . CYS A 1 168 ? 36.726 139.868 -6.823 1.00 227.22 ? 167 CYS A C 1 ATOM 1325 O O . CYS A 1 168 ? 35.589 139.545 -6.468 1.00 227.22 ? 167 CYS A O 1 ATOM 1326 C CB . CYS A 1 168 ? 38.710 138.325 -6.654 1.00 227.22 ? 167 CYS A CB 1 ATOM 1327 S SG . CYS A 1 168 ? 38.135 137.091 -5.453 1.00 227.22 ? 167 CYS A SG 1 ATOM 1328 N N . ALA A 1 169 ? 37.240 141.074 -6.591 1.00 227.22 ? 168 ALA A N 1 ATOM 1329 C CA . ALA A 1 169 ? 36.533 142.074 -5.790 1.00 227.22 ? 168 ALA A CA 1 ATOM 1330 C C . ALA A 1 169 ? 35.266 142.652 -6.439 1.00 227.22 ? 168 ALA A C 1 ATOM 1331 O O . ALA A 1 169 ? 34.362 143.117 -5.737 1.00 227.22 ? 168 ALA A O 1 ATOM 1332 C CB . ALA A 1 169 ? 37.482 143.193 -5.390 1.00 227.22 ? 168 ALA A CB 1 ATOM 1333 N N . ALA A 1 170 ? 35.199 142.613 -7.769 1.00 227.22 ? 169 ALA A N 1 ATOM 1334 C CA . ALA A 1 170 ? 34.149 143.321 -8.511 1.00 227.22 ? 169 ALA A CA 1 ATOM 1335 C C . ALA A 1 170 ? 32.922 142.494 -8.917 1.00 227.22 ? 169 ALA A C 1 ATOM 1336 O O . ALA A 1 170 ? 31.814 143.028 -8.925 1.00 227.22 ? 169 ALA A O 1 ATOM 1337 C CB . ALA A 1 170 ? 34.738 144.052 -9.722 1.00 227.22 ? 169 ALA A CB 1 ATOM 1338 N N . PRO A 1 171 ? 33.107 141.205 -9.273 1.00 227.22 ? 170 PRO A N 1 ATOM 1339 C CA . PRO A 1 171 ? 31.947 140.356 -9.590 1.00 227.22 ? 170 PRO A CA 1 ATOM 1340 C C . PRO A 1 171 ? 30.742 140.387 -8.614 1.00 227.22 ? 170 PRO A C 1 ATOM 1341 O O . PRO A 1 171 ? 29.608 140.241 -9.079 1.00 227.22 ? 170 PRO A O 1 ATOM 1342 C CB . PRO A 1 171 ? 32.556 138.958 -9.679 1.00 227.22 ? 170 PRO A CB 1 ATOM 1343 C CG . PRO A 1 171 ? 33.933 139.208 -10.139 1.00 227.22 ? 170 PRO A CG 1 ATOM 1344 C CD . PRO A 1 171 ? 34.372 140.472 -9.465 1.00 227.22 ? 170 PRO A CD 1 ATOM 1345 N N . PRO A 1 172 ? 30.970 140.553 -7.286 1.00 227.22 ? 171 PRO A N 1 ATOM 1346 C CA . PRO A 1 172 ? 29.815 140.755 -6.388 1.00 227.22 ? 171 PRO A CA 1 ATOM 1347 C C . PRO A 1 172 ? 29.038 142.064 -6.589 1.00 227.22 ? 171 PRO A C 1 ATOM 1348 O O . PRO A 1 172 ? 27.863 142.132 -6.224 1.00 227.22 ? 171 PRO A O 1 ATOM 1349 C CB . PRO A 1 172 ? 30.442 140.722 -4.991 1.00 227.22 ? 171 PRO A CB 1 ATOM 1350 C CG . PRO A 1 172 ? 31.858 141.070 -5.203 1.00 227.22 ? 171 PRO A CG 1 ATOM 1351 C CD . PRO A 1 172 ? 32.235 140.509 -6.527 1.00 227.22 ? 171 PRO A CD 1 ATOM 1352 N N . LEU A 1 173 ? 29.694 143.078 -7.159 1.00 227.22 ? 172 LEU A N 1 ATOM 1353 C CA . LEU A 1 173 ? 29.088 144.398 -7.418 1.00 227.22 ? 172 LEU A CA 1 ATOM 1354 C C . LEU A 1 173 ? 27.947 144.375 -8.435 1.00 227.22 ? 172 LEU A C 1 ATOM 1355 O O . LEU A 1 173 ? 26.965 145.113 -8.288 1.00 227.22 ? 172 LEU A O 1 ATOM 1356 C CB . LEU A 1 173 ? 30.138 145.397 -7.934 1.00 227.22 ? 172 LEU A CB 1 ATOM 1357 C CG . LEU A 1 173 ? 31.317 145.911 -7.098 1.00 227.22 ? 172 LEU A CG 1 ATOM 1358 C CD1 . LEU A 1 173 ? 32.356 146.546 -8.032 1.00 227.22 ? 172 LEU A CD1 1 ATOM 1359 C CD2 . LEU A 1 173 ? 30.877 146.897 -5.998 1.00 227.22 ? 172 LEU A CD2 1 ATOM 1360 N N . VAL A 1 174 ? 28.101 143.551 -9.474 1.00 227.22 ? 173 VAL A N 1 ATOM 1361 C CA . VAL A 1 174 ? 27.178 143.534 -10.623 1.00 227.22 ? 173 VAL A CA 1 ATOM 1362 C C . VAL A 1 174 ? 26.127 142.417 -10.594 1.00 227.22 ? 173 VAL A C 1 ATOM 1363 O O . VAL A 1 174 ? 24.936 142.681 -10.793 1.00 227.22 ? 173 VAL A O 1 ATOM 1364 C CB . VAL A 1 174 ? 27.928 143.513 -11.984 1.00 227.22 ? 173 VAL A CB 1 ATOM 1365 C CG1 . VAL A 1 174 ? 28.441 144.909 -12.331 1.00 227.22 ? 173 VAL A CG1 1 ATOM 1366 C CG2 . VAL A 1 174 ? 29.066 142.480 -11.977 1.00 227.22 ? 173 VAL A CG2 1 ATOM 1367 N N . GLY A 1 175 ? 26.562 141.180 -10.354 1.00 227.22 ? 174 GLY A N 1 ATOM 1368 C CA . GLY A 1 175 ? 25.631 140.057 -10.293 1.00 227.22 ? 174 GLY A CA 1 ATOM 1369 C C . GLY A 1 175 ? 26.186 138.688 -9.942 1.00 227.22 ? 174 GLY A C 1 ATOM 1370 O O . GLY A 1 175 ? 25.490 137.686 -10.103 1.00 227.22 ? 174 GLY A O 1 ATOM 1371 N N . TRP A 1 176 ? 27.427 138.623 -9.465 1.00 227.22 ? 175 TRP A N 1 ATOM 1372 C CA . TRP A 1 176 ? 28.003 137.338 -9.060 1.00 227.22 ? 175 TRP A CA 1 ATOM 1373 C C . TRP A 1 176 ? 28.456 137.341 -7.590 1.00 227.22 ? 175 TRP A C 1 ATOM 1374 O O . TRP A 1 176 ? 29.520 137.871 -7.249 1.00 227.22 ? 175 TRP A O 1 ATOM 1375 C CB . TRP A 1 176 ? 29.121 136.913 -10.020 1.00 227.22 ? 175 TRP A CB 1 ATOM 1376 C CG . TRP A 1 176 ? 29.329 135.422 -10.079 1.00 227.22 ? 175 TRP A CG 1 ATOM 1377 C CD1 . TRP A 1 176 ? 28.375 134.454 -9.927 1.00 227.22 ? 175 TRP A CD1 1 ATOM 1378 C CD2 . TRP A 1 176 ? 30.563 134.732 -10.328 1.00 227.22 ? 175 TRP A CD2 1 ATOM 1379 N NE1 . TRP A 1 176 ? 28.941 133.206 -10.050 1.00 227.22 ? 175 TRP A NE1 1 ATOM 1380 C CE2 . TRP A 1 176 ? 30.281 133.345 -10.298 1.00 227.22 ? 175 TRP A CE2 1 ATOM 1381 C CE3 . TRP A 1 176 ? 31.881 135.149 -10.566 1.00 227.22 ? 175 TRP A CE3 1 ATOM 1382 C CZ2 . TRP A 1 176 ? 31.266 132.372 -10.501 1.00 227.22 ? 175 TRP A CZ2 1 ATOM 1383 C CZ3 . TRP A 1 176 ? 32.861 134.179 -10.765 1.00 227.22 ? 175 TRP A CZ3 1 ATOM 1384 C CH2 . TRP A 1 176 ? 32.546 132.806 -10.729 1.00 227.22 ? 175 TRP A CH2 1 ATOM 1385 N N . SER A 1 177 ? 27.628 136.732 -6.737 1.00 227.22 ? 176 SER A N 1 ATOM 1386 C CA . SER A 1 177 ? 27.702 136.878 -5.275 1.00 227.22 ? 176 SER A CA 1 ATOM 1387 C C . SER A 1 177 ? 27.457 138.329 -4.861 1.00 227.22 ? 176 SER A C 1 ATOM 1388 O O . SER A 1 177 ? 27.188 139.184 -5.712 1.00 227.22 ? 176 SER A O 1 ATOM 1389 C CB . SER A 1 177 ? 29.024 136.344 -4.708 1.00 227.22 ? 176 SER A CB 1 ATOM 1390 O OG . SER A 1 177 ? 29.007 136.324 -3.290 1.00 227.22 ? 176 SER A OG 1 ATOM 1391 N N . ARG A 1 178 ? 27.530 138.609 -3.562 1.00 227.22 ? 177 ARG A N 1 ATOM 1392 C CA . ARG A 1 178 ? 27.329 139.974 -3.078 1.00 227.22 ? 177 ARG A CA 1 ATOM 1393 C C . ARG A 1 178 ? 28.203 140.330 -1.890 1.00 227.22 ? 177 ARG A C 1 ATOM 1394 O O . ARG A 1 178 ? 28.774 139.457 -1.236 1.00 227.22 ? 177 ARG A O 1 ATOM 1395 C CB . ARG A 1 178 ? 25.853 140.239 -2.749 1.00 227.22 ? 177 ARG A CB 1 ATOM 1396 C CG . ARG A 1 178 ? 25.294 139.408 -1.615 1.00 227.22 ? 177 ARG A CG 1 ATOM 1397 C CD . ARG A 1 178 ? 23.783 139.545 -1.530 1.00 227.22 ? 177 ARG A CD 1 ATOM 1398 N NE . ARG A 1 178 ? 23.190 138.525 -0.663 1.00 227.22 ? 177 ARG A NE 1 ATOM 1399 C CZ . ARG A 1 178 ? 21.889 138.398 -0.425 1.00 227.22 ? 177 ARG A CZ 1 ATOM 1400 N NH1 . ARG A 1 178 ? 21.021 139.227 -0.991 1.00 227.22 ? 177 ARG A NH1 1 ATOM 1401 N NH2 . ARG A 1 178 ? 21.455 137.438 0.379 1.00 227.22 ? 177 ARG A NH2 1 ATOM 1402 N N . TYR A 1 179 ? 28.300 141.630 -1.635 1.00 227.22 ? 178 TYR A N 1 ATOM 1403 C CA . TYR A 1 179 ? 28.949 142.129 -0.439 1.00 227.22 ? 178 TYR A CA 1 ATOM 1404 C C . TYR A 1 179 ? 27.942 142.286 0.680 1.00 227.22 ? 178 TYR A C 1 ATOM 1405 O O . TYR A 1 179 ? 26.964 143.032 0.564 1.00 227.22 ? 178 TYR A O 1 ATOM 1406 C CB . TYR A 1 179 ? 29.690 143.434 -0.707 1.00 227.22 ? 178 TYR A CB 1 ATOM 1407 C CG . TYR A 1 179 ? 31.013 143.215 -1.396 1.00 227.22 ? 178 TYR A CG 1 ATOM 1408 C CD1 . TYR A 1 179 ? 32.001 142.419 -0.815 1.00 227.22 ? 178 TYR A CD1 1 ATOM 1409 C CD2 . TYR A 1 179 ? 31.278 143.798 -2.631 1.00 227.22 ? 178 TYR A CD2 1 ATOM 1410 C CE1 . TYR A 1 179 ? 33.210 142.212 -1.446 1.00 227.22 ? 178 TYR A CE1 1 ATOM 1411 C CE2 . TYR A 1 179 ? 32.492 143.603 -3.267 1.00 227.22 ? 178 TYR A CE2 1 ATOM 1412 C CZ . TYR A 1 179 ? 33.448 142.808 -2.670 1.00 227.22 ? 178 TYR A CZ 1 ATOM 1413 O OH . TYR A 1 179 ? 34.644 142.612 -3.303 1.00 227.22 ? 178 TYR A OH 1 ATOM 1414 N N . ILE A 1 180 ? 28.217 141.570 1.764 1.00 227.22 ? 179 ILE A N 1 ATOM 1415 C CA . ILE A 1 180 ? 27.277 141.358 2.845 1.00 227.22 ? 179 ILE A CA 1 ATOM 1416 C C . ILE A 1 180 ? 27.993 141.570 4.196 1.00 227.22 ? 179 ILE A C 1 ATOM 1417 O O . ILE A 1 180 ? 29.165 141.206 4.325 1.00 227.22 ? 179 ILE A O 1 ATOM 1418 C CB . ILE A 1 180 ? 26.641 139.945 2.699 1.00 227.22 ? 179 ILE A CB 1 ATOM 1419 C CG1 . ILE A 1 180 ? 25.459 139.765 3.652 1.00 227.22 ? 179 ILE A CG1 1 ATOM 1420 C CG2 . ILE A 1 180 ? 27.693 138.847 2.846 1.00 227.22 ? 179 ILE A CG2 1 ATOM 1421 C CD1 . ILE A 1 180 ? 24.323 138.951 3.079 1.00 227.22 ? 179 ILE A CD1 1 ATOM 1422 N N . PRO A 1 181 ? 27.309 142.201 5.183 1.00 227.22 ? 180 PRO A N 1 ATOM 1423 C CA . PRO A 1 181 ? 27.835 142.482 6.534 1.00 227.22 ? 180 PRO A CA 1 ATOM 1424 C C . PRO A 1 181 ? 28.386 141.275 7.291 1.00 227.22 ? 180 PRO A C 1 ATOM 1425 O O . PRO A 1 181 ? 27.931 140.148 7.077 1.00 227.22 ? 180 PRO A O 1 ATOM 1426 C CB . PRO A 1 181 ? 26.620 143.045 7.263 1.00 227.22 ? 180 PRO A CB 1 ATOM 1427 C CG . PRO A 1 181 ? 25.823 143.665 6.198 1.00 227.22 ? 180 PRO A CG 1 ATOM 1428 C CD . PRO A 1 181 ? 25.948 142.745 5.032 1.00 227.22 ? 180 PRO A CD 1 ATOM 1429 N N . GLU A 1 182 ? 29.345 141.525 8.183 1.00 227.22 ? 181 GLU A N 1 ATOM 1430 C CA . GLU A 1 182 ? 30.144 140.456 8.790 1.00 227.22 ? 181 GLU A CA 1 ATOM 1431 C C . GLU A 1 182 ? 30.314 140.550 10.310 1.00 227.22 ? 181 GLU A C 1 ATOM 1432 O O . GLU A 1 182 ? 30.773 141.575 10.828 1.00 227.22 ? 181 GLU A O 1 ATOM 1433 C CB . GLU A 1 182 ? 31.532 140.402 8.141 1.00 227.22 ? 181 GLU A CB 1 ATOM 1434 C CG . GLU A 1 182 ? 31.554 139.854 6.724 1.00 227.22 ? 181 GLU A CG 1 ATOM 1435 C CD . GLU A 1 182 ? 32.832 139.098 6.411 1.00 227.22 ? 181 GLU A CD 1 ATOM 1436 O OE1 . GLU A 1 182 ? 33.914 139.541 6.850 1.00 227.22 ? 181 GLU A OE1 1 ATOM 1437 O OE2 . GLU A 1 182 ? 32.754 138.059 5.722 1.00 227.22 ? 181 GLU A OE2 1 ATOM 1438 N N . GLY A 1 183 ? 29.971 139.462 11.006 1.00 227.22 ? 182 GLY A N 1 ATOM 1439 C CA . GLY A 1 183 ? 30.190 139.337 12.449 1.00 227.22 ? 182 GLY A CA 1 ATOM 1440 C C . GLY A 1 183 ? 29.492 140.411 13.259 1.00 227.22 ? 182 GLY A C 1 ATOM 1441 O O . GLY A 1 183 ? 28.302 140.309 13.537 1.00 227.22 ? 182 GLY A O 1 ATOM 1442 N N . MET A 1 184 ? 30.224 141.453 13.632 1.00 227.22 ? 183 MET A N 1 ATOM 1443 C CA . MET A 1 184 ? 29.603 142.596 14.282 1.00 227.22 ? 183 MET A CA 1 ATOM 1444 C C . MET A 1 184 ? 28.939 143.497 13.242 1.00 227.22 ? 183 MET A C 1 ATOM 1445 O O . MET A 1 184 ? 28.565 144.635 13.532 1.00 227.22 ? 183 MET A O 1 ATOM 1446 C CB . MET A 1 184 ? 30.615 143.355 15.139 1.00 227.22 ? 183 MET A CB 1 ATOM 1447 C CG . MET A 1 184 ? 30.979 142.618 16.428 1.00 227.22 ? 183 MET A CG 1 ATOM 1448 S SD . MET A 1 184 ? 31.551 143.667 17.780 1.00 227.22 ? 183 MET A SD 1 ATOM 1449 C CE . MET A 1 184 ? 32.187 142.403 18.879 1.00 227.22 ? 183 MET A CE 1 ATOM 1450 N N . GLN A 1 185 ? 28.795 142.948 12.033 1.00 227.22 ? 184 GLN A N 1 ATOM 1451 C CA . GLN A 1 185 ? 28.144 143.581 10.867 1.00 227.22 ? 184 GLN A CA 1 ATOM 1452 C C . GLN A 1 185 ? 28.868 144.808 10.314 1.00 227.22 ? 184 GLN A C 1 ATOM 1453 O O . GLN A 1 185 ? 28.696 145.170 9.147 1.00 227.22 ? 184 GLN A O 1 ATOM 1454 C CB . GLN A 1 185 ? 26.662 143.867 11.141 1.00 227.22 ? 184 GLN A CB 1 ATOM 1455 C CG . GLN A 1 185 ? 25.894 142.661 11.673 1.00 227.22 ? 184 GLN A CG 1 ATOM 1456 C CD . GLN A 1 185 ? 26.072 141.418 10.810 1.00 227.22 ? 184 GLN A CD 1 ATOM 1457 O OE1 . GLN A 1 185 ? 25.413 141.261 9.783 1.00 227.22 ? 184 GLN A OE1 1 ATOM 1458 N NE2 . GLN A 1 185 ? 26.961 140.525 11.231 1.00 227.22 ? 184 GLN A NE2 1 ATOM 1459 N N . CYS A 1 186 ? 29.692 145.420 11.160 1.00 227.22 ? 185 CYS A N 1 ATOM 1460 C CA . CYS A 1 186 ? 30.444 146.626 10.832 1.00 227.22 ? 185 CYS A CA 1 ATOM 1461 C C . CYS A 1 186 ? 31.338 146.438 9.599 1.00 227.22 ? 185 CYS A C 1 ATOM 1462 O O . CYS A 1 186 ? 31.373 147.292 8.714 1.00 227.22 ? 185 CYS A O 1 ATOM 1463 C CB . CYS A 1 186 ? 31.253 147.076 12.058 1.00 227.22 ? 185 CYS A CB 1 ATOM 1464 S SG . CYS A 1 186 ? 30.254 147.294 13.569 1.00 227.22 ? 185 CYS A SG 1 ATOM 1465 N N . SER A 1 187 ? 32.049 145.315 9.551 1.00 227.22 ? 186 SER A N 1 ATOM 1466 C CA . SER A 1 187 ? 32.797 144.932 8.362 1.00 227.22 ? 186 SER A CA 1 ATOM 1467 C C . SER A 1 187 ? 31.854 144.220 7.391 1.00 227.22 ? 186 SER A C 1 ATOM 1468 O O . SER A 1 187 ? 30.883 143.589 7.826 1.00 227.22 ? 186 SER A O 1 ATOM 1469 C CB . SER A 1 187 ? 33.981 144.026 8.727 1.00 227.22 ? 186 SER A CB 1 ATOM 1470 O OG . SER A 1 187 ? 33.556 142.732 9.121 1.00 227.22 ? 186 SER A OG 1 ATOM 1471 N N . CYS A 1 188 ? 32.138 144.352 6.088 1.00 227.22 ? 187 CYS A N 1 ATOM 1472 C CA . CYS A 1 188 ? 31.415 143.663 5.009 1.00 227.22 ? 187 CYS A CA 1 ATOM 1473 C C . CYS A 1 188 ? 32.374 142.818 4.182 1.00 227.22 ? 187 CYS A C 1 ATOM 1474 O O . CYS A 1 188 ? 33.538 143.179 4.024 1.00 227.22 ? 187 CYS A O 1 ATOM 1475 C CB . CYS A 1 188 ? 30.716 144.669 4.095 1.00 227.22 ? 187 CYS A CB 1 ATOM 1476 S SG . CYS A 1 188 ? 29.079 145.229 4.639 1.00 227.22 ? 187 CYS A SG 1 ATOM 1477 N N . GLY A 1 189 ? 31.877 141.700 3.657 1.00 227.22 ? 188 GLY A N 1 ATOM 1478 C CA . GLY A 1 189 ? 32.676 140.775 2.841 1.00 227.22 ? 188 GLY A CA 1 ATOM 1479 C C . GLY A 1 189 ? 31.821 139.905 1.935 1.00 227.22 ? 188 GLY A C 1 ATOM 1480 O O . GLY A 1 189 ? 30.628 140.168 1.772 1.00 227.22 ? 188 GLY A O 1 ATOM 1481 N N . ILE A 1 190 ? 32.421 138.867 1.349 1.00 227.22 ? 189 ILE A N 1 ATOM 1482 C CA . ILE A 1 190 ? 31.696 137.978 0.421 1.00 227.22 ? 189 ILE A CA 1 ATOM 1483 C C . ILE A 1 190 ? 30.560 137.208 1.114 1.00 227.22 ? 189 ILE A C 1 ATOM 1484 O O . ILE A 1 190 ? 30.628 136.922 2.310 1.00 227.22 ? 189 ILE A O 1 ATOM 1485 C CB . ILE A 1 190 ? 32.669 137.059 -0.421 1.00 227.22 ? 189 ILE A CB 1 ATOM 1486 C CG1 . ILE A 1 190 ? 33.245 137.842 -1.603 1.00 227.22 ? 189 ILE A CG1 1 ATOM 1487 C CG2 . ILE A 1 190 ? 31.985 135.791 -0.961 1.00 227.22 ? 189 ILE A CG2 1 ATOM 1488 C CD1 . ILE A 1 190 ? 32.193 138.503 -2.501 1.00 227.22 ? 189 ILE A CD1 1 ATOM 1489 N N . ASP A 1 191 ? 29.503 136.924 0.354 1.00 227.22 ? 190 ASP A N 1 ATOM 1490 C CA . ASP A 1 191 ? 28.372 136.133 0.828 1.00 227.22 ? 190 ASP A CA 1 ATOM 1491 C C . ASP A 1 191 ? 28.712 134.640 0.844 1.00 227.22 ? 190 ASP A C 1 ATOM 1492 O O . ASP A 1 191 ? 28.573 133.948 -0.173 1.00 227.22 ? 190 ASP A O 1 ATOM 1493 C CB . ASP A 1 191 ? 27.143 136.412 -0.050 1.00 227.22 ? 190 ASP A CB 1 ATOM 1494 C CG . ASP A 1 191 ? 25.919 135.607 0.364 1.00 227.22 ? 190 ASP A CG 1 ATOM 1495 O OD1 . ASP A 1 191 ? 26.023 134.374 0.538 1.00 227.22 ? 190 ASP A OD1 1 ATOM 1496 O OD2 . ASP A 1 191 ? 24.833 136.212 0.490 1.00 227.22 ? 190 ASP A OD2 1 ATOM 1497 N N . TYR A 1 192 ? 29.166 134.153 1.996 1.00 227.22 ? 191 TYR A N 1 ATOM 1498 C CA . TYR A 1 192 ? 29.404 132.726 2.171 1.00 227.22 ? 191 TYR A CA 1 ATOM 1499 C C . TYR A 1 192 ? 28.237 132.079 2.913 1.00 227.22 ? 191 TYR A C 1 ATOM 1500 O O . TYR A 1 192 ? 27.962 130.893 2.729 1.00 227.22 ? 191 TYR A O 1 ATOM 1501 C CB . TYR A 1 192 ? 30.681 132.443 2.967 1.00 227.22 ? 191 TYR A CB 1 ATOM 1502 C CG . TYR A 1 192 ? 31.831 133.423 2.841 1.00 227.22 ? 191 TYR A CG 1 ATOM 1503 C CD1 . TYR A 1 192 ? 32.919 133.148 2.020 1.00 227.22 ? 191 TYR A CD1 1 ATOM 1504 C CD2 . TYR A 1 192 ? 31.865 134.591 3.600 1.00 227.22 ? 191 TYR A CD2 1 ATOM 1505 C CE1 . TYR A 1 192 ? 33.994 134.033 1.927 1.00 227.22 ? 191 TYR A CE1 1 ATOM 1506 C CE2 . TYR A 1 192 ? 32.935 135.483 3.512 1.00 227.22 ? 191 TYR A CE2 1 ATOM 1507 C CZ . TYR A 1 192 ? 33.994 135.199 2.675 1.00 227.22 ? 191 TYR A CZ 1 ATOM 1508 O OH . TYR A 1 192 ? 35.049 136.079 2.584 1.00 227.22 ? 191 TYR A OH 1 ATOM 1509 N N . TYR A 1 193 ? 27.562 132.880 3.745 1.00 227.22 ? 192 TYR A N 1 ATOM 1510 C CA . TYR A 1 193 ? 26.610 132.418 4.785 1.00 227.22 ? 192 TYR A CA 1 ATOM 1511 C C . TYR A 1 193 ? 25.295 131.853 4.273 1.00 227.22 ? 192 TYR A C 1 ATOM 1512 O O . TYR A 1 193 ? 24.577 131.155 5.006 1.00 227.22 ? 192 TYR A O 1 ATOM 1513 C CB . TYR A 1 193 ? 26.286 133.565 5.745 1.00 227.22 ? 192 TYR A CB 1 ATOM 1514 C CG . TYR A 1 193 ? 27.480 134.417 6.081 1.00 227.22 ? 192 TYR A CG 1 ATOM 1515 C CD1 . TYR A 1 193 ? 28.438 133.974 6.987 1.00 227.22 ? 192 TYR A CD1 1 ATOM 1516 C CD2 . TYR A 1 193 ? 27.659 135.662 5.485 1.00 227.22 ? 192 TYR A CD2 1 ATOM 1517 C CE1 . TYR A 1 193 ? 29.536 134.745 7.296 1.00 227.22 ? 192 TYR A CE1 1 ATOM 1518 C CE2 . TYR A 1 193 ? 28.760 136.448 5.789 1.00 227.22 ? 192 TYR A CE2 1 ATOM 1519 C CZ . TYR A 1 193 ? 29.694 135.981 6.696 1.00 227.22 ? 192 TYR A CZ 1 ATOM 1520 O OH . TYR A 1 193 ? 30.791 136.749 7.001 1.00 227.22 ? 192 TYR A OH 1 ATOM 1521 N N . THR A 1 194 ? 24.982 132.190 3.023 1.00 227.22 ? 193 THR A N 1 ATOM 1522 C CA . THR A 1 194 ? 23.738 131.791 2.373 1.00 227.22 ? 193 THR A CA 1 ATOM 1523 C C . THR A 1 194 ? 23.998 131.269 0.960 1.00 227.22 ? 193 THR A C 1 ATOM 1524 O O . THR A 1 194 ? 25.035 131.583 0.356 1.00 227.22 ? 193 THR A O 1 ATOM 1525 C CB . THR A 1 194 ? 22.711 132.968 2.286 1.00 227.22 ? 193 THR A CB 1 ATOM 1526 O OG1 . THR A 1 194 ? 23.066 133.862 1.218 1.00 227.22 ? 193 THR A OG1 1 ATOM 1527 C CG2 . THR A 1 194 ? 22.619 133.735 3.613 1.00 227.22 ? 193 THR A CG2 1 ATOM 1528 N N . PRO A 1 195 ? 23.068 130.448 0.439 1.00 227.22 ? 194 PRO A N 1 ATOM 1529 C CA . PRO A 1 195 ? 23.082 130.149 -0.991 1.00 227.22 ? 194 PRO A CA 1 ATOM 1530 C C . PRO A 1 195 ? 22.757 131.366 -1.893 1.00 227.22 ? 194 PRO A C 1 ATOM 1531 O O . PRO A 1 195 ? 23.562 131.695 -2.771 1.00 227.22 ? 194 PRO A O 1 ATOM 1532 C CB . PRO A 1 195 ? 22.029 129.038 -1.131 1.00 227.22 ? 194 PRO A CB 1 ATOM 1533 C CG . PRO A 1 195 ? 21.149 129.171 0.065 1.00 227.22 ? 194 PRO A CG 1 ATOM 1534 C CD . PRO A 1 195 ? 22.007 129.712 1.157 1.00 227.22 ? 194 PRO A CD 1 ATOM 1535 N N . HIS A 1 196 ? 21.620 132.031 -1.646 1.00 227.22 ? 195 HIS A N 1 ATOM 1536 C CA . HIS A 1 196 ? 21.039 133.041 -2.559 1.00 227.22 ? 195 HIS A CA 1 ATOM 1537 C C . HIS A 1 196 ? 21.344 132.750 -4.022 1.00 227.22 ? 195 HIS A C 1 ATOM 1538 O O . HIS A 1 196 ? 22.369 133.186 -4.557 1.00 227.22 ? 195 HIS A O 1 ATOM 1539 C CB . HIS A 1 196 ? 21.451 134.469 -2.195 1.00 227.22 ? 195 HIS A CB 1 ATOM 1540 C CG . HIS A 1 196 ? 20.699 135.523 -2.951 1.00 227.22 ? 195 HIS A CG 1 ATOM 1541 N ND1 . HIS A 1 196 ? 21.312 136.406 -3.814 1.00 227.22 ? 195 HIS A ND1 1 ATOM 1542 C CD2 . HIS A 1 196 ? 19.381 135.834 -2.972 1.00 227.22 ? 195 HIS A CD2 1 ATOM 1543 C CE1 . HIS A 1 196 ? 20.405 137.219 -4.326 1.00 227.22 ? 195 HIS A CE1 1 ATOM 1544 N NE2 . HIS A 1 196 ? 19.225 136.891 -3.834 1.00 227.22 ? 195 HIS A NE2 1 ATOM 1545 N N . GLU A 1 197 ? 20.426 132.023 -4.652 1.00 227.22 ? 196 GLU A N 1 ATOM 1546 C CA . GLU A 1 197 ? 20.624 131.426 -5.979 1.00 227.22 ? 196 GLU A CA 1 ATOM 1547 C C . GLU A 1 197 ? 20.601 132.428 -7.137 1.00 227.22 ? 196 GLU A C 1 ATOM 1548 O O . GLU A 1 197 ? 21.238 132.212 -8.170 1.00 227.22 ? 196 GLU A O 1 ATOM 1549 C CB . GLU A 1 197 ? 19.570 130.338 -6.210 1.00 227.22 ? 196 GLU A CB 1 ATOM 1550 C CG . GLU A 1 197 ? 19.278 129.471 -4.977 1.00 227.22 ? 196 GLU A CG 1 ATOM 1551 C CD . GLU A 1 197 ? 20.358 128.436 -4.685 1.00 227.22 ? 196 GLU A CD 1 ATOM 1552 O OE1 . GLU A 1 197 ? 21.541 128.650 -5.042 1.00 227.22 ? 196 GLU A OE1 1 ATOM 1553 O OE2 . GLU A 1 197 ? 20.010 127.397 -4.087 1.00 227.22 ? 196 GLU A OE2 1 ATOM 1554 N N . GLU A 1 198 ? 19.873 133.524 -6.943 1.00 227.22 ? 197 GLU A N 1 ATOM 1555 C CA . GLU A 1 198 ? 19.713 134.576 -7.948 1.00 227.22 ? 197 GLU A CA 1 ATOM 1556 C C . GLU A 1 198 ? 21.001 135.381 -8.206 1.00 227.22 ? 197 GLU A C 1 ATOM 1557 O O . GLU A 1 198 ? 20.991 136.319 -9.006 1.00 227.22 ? 197 GLU A O 1 ATOM 1558 C CB . GLU A 1 198 ? 18.561 135.518 -7.546 1.00 227.22 ? 197 GLU A CB 1 ATOM 1559 C CG . GLU A 1 198 ? 17.195 134.831 -7.277 1.00 227.22 ? 197 GLU A CG 1 ATOM 1560 C CD . GLU A 1 198 ? 16.999 134.354 -5.828 1.00 227.22 ? 197 GLU A CD 1 ATOM 1561 O OE1 . GLU A 1 198 ? 16.760 133.139 -5.631 1.00 227.22 ? 197 GLU A OE1 1 ATOM 1562 O OE2 . GLU A 1 198 ? 17.068 135.190 -4.896 1.00 227.22 ? 197 GLU A OE2 1 ATOM 1563 N N . THR A 1 199 ? 22.092 135.015 -7.522 1.00 227.22 ? 198 THR A N 1 ATOM 1564 C CA . THR A 1 199 ? 23.416 135.657 -7.685 1.00 227.22 ? 198 THR A CA 1 ATOM 1565 C C . THR A 1 199 ? 24.562 134.656 -7.912 1.00 227.22 ? 198 THR A C 1 ATOM 1566 O O . THR A 1 199 ? 25.672 135.053 -8.294 1.00 227.22 ? 198 THR A O 1 ATOM 1567 C CB . THR A 1 199 ? 23.797 136.609 -6.489 1.00 227.22 ? 198 THR A CB 1 ATOM 1568 O OG1 . THR A 1 199 ? 23.572 135.956 -5.231 1.00 227.22 ? 198 THR A OG1 1 ATOM 1569 C CG2 . THR A 1 199 ? 23.006 137.918 -6.540 1.00 227.22 ? 198 THR A CG2 1 ATOM 1570 N N . ASN A 1 200 ? 24.281 133.369 -7.681 1.00 227.22 ? 199 ASN A N 1 ATOM 1571 C CA . ASN A 1 200 ? 25.269 132.285 -7.812 1.00 227.22 ? 199 ASN A CA 1 ATOM 1572 C C . ASN A 1 200 ? 26.400 132.373 -6.766 1.00 227.22 ? 199 ASN A C 1 ATOM 1573 O O . ASN A 1 200 ? 27.585 132.452 -7.123 1.00 227.22 ? 199 ASN A O 1 ATOM 1574 C CB . ASN A 1 200 ? 25.865 132.245 -9.236 1.00 227.22 ? 199 ASN A CB 1 ATOM 1575 C CG . ASN A 1 200 ? 24.916 131.653 -10.276 1.00 227.22 ? 199 ASN A CG 1 ATOM 1576 O OD1 . ASN A 1 200 ? 24.830 130.431 -10.428 1.00 227.22 ? 199 ASN A OD1 1 ATOM 1577 N ND2 . ASN A 1 200 ? 24.242 132.522 -11.034 1.00 227.22 ? 199 ASN A ND2 1 ATOM 1578 N N . ASN A 1 201 ? 26.036 132.355 -5.482 1.00 227.22 ? 200 ASN A N 1 ATOM 1579 C CA . ASN A 1 201 ? 27.022 132.496 -4.392 1.00 227.22 ? 200 ASN A CA 1 ATOM 1580 C C . ASN A 1 201 ? 27.795 131.217 -4.088 1.00 227.22 ? 200 ASN A C 1 ATOM 1581 O O . ASN A 1 201 ? 28.696 131.211 -3.241 1.00 227.22 ? 200 ASN A O 1 ATOM 1582 C CB . ASN A 1 201 ? 26.364 133.010 -3.110 1.00 227.22 ? 200 ASN A CB 1 ATOM 1583 C CG . ASN A 1 201 ? 25.550 134.262 -3.337 1.00 227.22 ? 200 ASN A CG 1 ATOM 1584 O OD1 . ASN A 1 201 ? 25.859 135.073 -4.210 1.00 227.22 ? 200 ASN A OD1 1 ATOM 1585 N ND2 . ASN A 1 201 ? 24.497 134.425 -2.552 1.00 227.22 ? 200 ASN A ND2 1 ATOM 1586 N N . GLU A 1 202 ? 27.428 130.140 -4.779 1.00 227.22 ? 201 GLU A N 1 ATOM 1587 C CA . GLU A 1 202 ? 28.092 128.858 -4.620 1.00 227.22 ? 201 GLU A CA 1 ATOM 1588 C C . GLU A 1 202 ? 29.270 128.770 -5.574 1.00 227.22 ? 201 GLU A C 1 ATOM 1589 O O . GLU A 1 202 ? 30.393 128.450 -5.168 1.00 227.22 ? 201 GLU A O 1 ATOM 1590 C CB . GLU A 1 202 ? 27.111 127.714 -4.882 1.00 227.22 ? 201 GLU A CB 1 ATOM 1591 C CG . GLU A 1 202 ? 27.415 126.441 -4.086 1.00 227.22 ? 201 GLU A CG 1 ATOM 1592 C CD . GLU A 1 202 ? 27.179 126.595 -2.584 1.00 227.22 ? 201 GLU A CD 1 ATOM 1593 O OE1 . GLU A 1 202 ? 26.264 127.352 -2.184 1.00 227.22 ? 201 GLU A OE1 1 ATOM 1594 O OE2 . GLU A 1 202 ? 27.908 125.946 -1.804 1.00 227.22 ? 201 GLU A OE2 1 ATOM 1595 N N . SER A 1 203 ? 28.999 129.067 -6.842 1.00 227.22 ? 202 SER A N 1 ATOM 1596 C CA . SER A 1 203 ? 30.016 129.060 -7.886 1.00 227.22 ? 202 SER A CA 1 ATOM 1597 C C . SER A 1 203 ? 31.064 130.143 -7.659 1.00 227.22 ? 202 SER A C 1 ATOM 1598 O O . SER A 1 203 ? 32.254 129.915 -7.885 1.00 227.22 ? 202 SER A O 1 ATOM 1599 C CB . SER A 1 203 ? 29.368 129.244 -9.260 1.00 227.22 ? 202 SER A CB 1 ATOM 1600 O OG . SER A 1 203 ? 28.734 130.509 -9.362 1.00 227.22 ? 202 SER A OG 1 ATOM 1601 N N . PHE A 1 204 ? 30.615 131.315 -7.214 1.00 227.22 ? 203 PHE A N 1 ATOM 1602 C CA . PHE A 1 204 ? 31.518 132.422 -6.955 1.00 227.22 ? 203 PHE A CA 1 ATOM 1603 C C . PHE A 1 204 ? 32.544 132.061 -5.893 1.00 227.22 ? 203 PHE A C 1 ATOM 1604 O O . PHE A 1 204 ? 33.743 132.228 -6.101 1.00 227.22 ? 203 PHE A O 1 ATOM 1605 C CB . PHE A 1 204 ? 30.756 133.669 -6.523 1.00 227.22 ? 203 PHE A CB 1 ATOM 1606 C CG . PHE A 1 204 ? 31.646 134.841 -6.259 1.00 227.22 ? 203 PHE A CG 1 ATOM 1607 C CD1 . PHE A 1 204 ? 32.368 134.931 -5.077 1.00 227.22 ? 203 PHE A CD1 1 ATOM 1608 C CD2 . PHE A 1 204 ? 31.780 135.844 -7.197 1.00 227.22 ? 203 PHE A CD2 1 ATOM 1609 C CE1 . PHE A 1 204 ? 33.204 136.000 -4.839 1.00 227.22 ? 203 PHE A CE1 1 ATOM 1610 C CE2 . PHE A 1 204 ? 32.608 136.921 -6.964 1.00 227.22 ? 203 PHE A CE2 1 ATOM 1611 C CZ . PHE A 1 204 ? 33.322 137.002 -5.784 1.00 227.22 ? 203 PHE A CZ 1 ATOM 1612 N N . VAL A 1 205 ? 32.059 131.570 -4.755 1.00 227.22 ? 204 VAL A N 1 ATOM 1613 C CA . VAL A 1 205 ? 32.915 131.277 -3.608 1.00 227.22 ? 204 VAL A CA 1 ATOM 1614 C C . VAL A 1 205 ? 33.986 130.251 -3.967 1.00 227.22 ? 204 VAL A C 1 ATOM 1615 O O . VAL A 1 205 ? 35.180 130.530 -3.823 1.00 227.22 ? 204 VAL A O 1 ATOM 1616 C CB . VAL A 1 205 ? 32.092 130.861 -2.363 1.00 227.22 ? 204 VAL A CB 1 ATOM 1617 C CG1 . VAL A 1 205 ? 32.989 130.265 -1.286 1.00 227.22 ? 204 VAL A CG1 1 ATOM 1618 C CG2 . VAL A 1 205 ? 31.345 132.068 -1.811 1.00 227.22 ? 204 VAL A CG2 1 ATOM 1619 N N . ILE A 1 206 ? 33.559 129.084 -4.452 1.00 227.22 ? 205 ILE A N 1 ATOM 1620 C CA . ILE A 1 206 ? 34.490 128.053 -4.913 1.00 227.22 ? 205 ILE A CA 1 ATOM 1621 C C . ILE A 1 206 ? 35.579 128.706 -5.763 1.00 227.22 ? 205 ILE A C 1 ATOM 1622 O O . ILE A 1 206 ? 36.759 128.657 -5.411 1.00 227.22 ? 205 ILE A O 1 ATOM 1623 C CB . ILE A 1 206 ? 33.773 126.926 -5.713 1.00 227.22 ? 205 ILE A CB 1 ATOM 1624 C CG1 . ILE A 1 206 ? 32.853 126.095 -4.801 1.00 227.22 ? 205 ILE A CG1 1 ATOM 1625 C CG2 . ILE A 1 206 ? 34.790 126.032 -6.442 1.00 227.22 ? 205 ILE A CG2 1 ATOM 1626 C CD1 . ILE A 1 206 ? 33.528 124.916 -4.087 1.00 227.22 ? 205 ILE A CD1 1 ATOM 1627 N N . TYR A 1 207 ? 35.166 129.342 -6.858 1.00 227.22 ? 206 TYR A N 1 ATOM 1628 C CA . TYR A 1 207 ? 36.077 130.083 -7.722 1.00 227.22 ? 206 TYR A CA 1 ATOM 1629 C C . TYR A 1 207 ? 36.967 131.029 -6.906 1.00 227.22 ? 206 TYR A C 1 ATOM 1630 O O . TYR A 1 207 ? 38.187 131.042 -7.083 1.00 227.22 ? 206 TYR A O 1 ATOM 1631 C CB . TYR A 1 207 ? 35.294 130.835 -8.819 1.00 227.22 ? 206 TYR A CB 1 ATOM 1632 C CG . TYR A 1 207 ? 35.754 132.258 -9.033 1.00 227.22 ? 206 TYR A CG 1 ATOM 1633 C CD1 . TYR A 1 207 ? 36.840 132.541 -9.849 1.00 227.22 ? 206 TYR A CD1 1 ATOM 1634 C CD2 . TYR A 1 207 ? 35.112 133.322 -8.396 1.00 227.22 ? 206 TYR A CD2 1 ATOM 1635 C CE1 . TYR A 1 207 ? 37.278 133.840 -10.028 1.00 227.22 ? 206 TYR A CE1 1 ATOM 1636 C CE2 . TYR A 1 207 ? 35.542 134.627 -8.567 1.00 227.22 ? 206 TYR A CE2 1 ATOM 1637 C CZ . TYR A 1 207 ? 36.622 134.879 -9.387 1.00 227.22 ? 206 TYR A CZ 1 ATOM 1638 O OH . TYR A 1 207 ? 37.050 136.169 -9.561 1.00 227.22 ? 206 TYR A OH 1 ATOM 1639 N N . MET A 1 208 ? 36.346 131.788 -5.999 1.00 227.22 ? 207 MET A N 1 ATOM 1640 C CA . MET A 1 208 ? 37.024 132.852 -5.262 1.00 227.22 ? 207 MET A CA 1 ATOM 1641 C C . MET A 1 208 ? 38.164 132.301 -4.429 1.00 227.22 ? 207 MET A C 1 ATOM 1642 O O . MET A 1 208 ? 39.227 132.911 -4.332 1.00 227.22 ? 207 MET A O 1 ATOM 1643 C CB . MET A 1 208 ? 36.037 133.608 -4.378 1.00 227.22 ? 207 MET A CB 1 ATOM 1644 C CG . MET A 1 208 ? 36.641 134.802 -3.663 1.00 227.22 ? 207 MET A CG 1 ATOM 1645 S SD . MET A 1 208 ? 35.648 135.383 -2.276 1.00 227.22 ? 207 MET A SD 1 ATOM 1646 C CE . MET A 1 208 ? 35.773 133.974 -1.168 1.00 227.22 ? 207 MET A CE 1 ATOM 1647 N N . PHE A 1 209 ? 37.931 131.140 -3.830 1.00 227.22 ? 208 PHE A N 1 ATOM 1648 C CA . PHE A 1 209 ? 38.985 130.419 -3.141 1.00 227.22 ? 208 PHE A CA 1 ATOM 1649 C C . PHE A 1 209 ? 39.972 129.850 -4.144 1.00 227.22 ? 208 PHE A C 1 ATOM 1650 O O . PHE A 1 209 ? 41.173 130.100 -4.054 1.00 227.22 ? 208 PHE A O 1 ATOM 1651 C CB . PHE A 1 209 ? 38.400 129.297 -2.280 1.00 227.22 ? 208 PHE A CB 1 ATOM 1652 C CG . PHE A 1 209 ? 38.127 129.706 -0.865 1.00 227.22 ? 208 PHE A CG 1 ATOM 1653 C CD1 . PHE A 1 209 ? 39.005 129.345 0.153 1.00 227.22 ? 208 PHE A CD1 1 ATOM 1654 C CD2 . PHE A 1 209 ? 37.001 130.465 -0.549 1.00 227.22 ? 208 PHE A CD2 1 ATOM 1655 C CE1 . PHE A 1 209 ? 38.762 129.723 1.473 1.00 227.22 ? 208 PHE A CE1 1 ATOM 1656 C CE2 . PHE A 1 209 ? 36.750 130.850 0.763 1.00 227.22 ? 208 PHE A CE2 1 ATOM 1657 C CZ . PHE A 1 209 ? 37.632 130.476 1.780 1.00 227.22 ? 208 PHE A CZ 1 ATOM 1658 N N . VAL A 1 210 ? 39.447 129.103 -5.111 1.00 227.22 ? 209 VAL A N 1 ATOM 1659 C CA . VAL A 1 210 ? 40.279 128.394 -6.073 1.00 227.22 ? 209 VAL A CA 1 ATOM 1660 C C . VAL A 1 210 ? 41.189 129.365 -6.816 1.00 227.22 ? 209 VAL A C 1 ATOM 1661 O O . VAL A 1 210 ? 42.410 129.341 -6.646 1.00 227.22 ? 209 VAL A O 1 ATOM 1662 C CB . VAL A 1 210 ? 39.429 127.552 -7.058 1.00 227.22 ? 209 VAL A CB 1 ATOM 1663 C CG1 . VAL A 1 210 ? 40.305 126.927 -8.135 1.00 227.22 ? 209 VAL A CG1 1 ATOM 1664 C CG2 . VAL A 1 210 ? 38.678 126.460 -6.309 1.00 227.22 ? 209 VAL A CG2 1 ATOM 1665 N N . VAL A 1 211 ? 40.584 130.237 -7.609 1.00 227.22 ? 210 VAL A N 1 ATOM 1666 C CA . VAL A 1 211 ? 41.335 131.141 -8.459 1.00 227.22 ? 210 VAL A CA 1 ATOM 1667 C C . VAL A 1 211 ? 42.171 132.109 -7.636 1.00 227.22 ? 210 VAL A C 1 ATOM 1668 O O . VAL A 1 211 ? 43.336 132.354 -7.945 1.00 227.22 ? 210 VAL A O 1 ATOM 1669 C CB . VAL A 1 211 ? 40.397 131.904 -9.414 1.00 227.22 ? 210 VAL A CB 1 ATOM 1670 C CG1 . VAL A 1 211 ? 41.185 132.851 -10.309 1.00 227.22 ? 210 VAL A CG1 1 ATOM 1671 C CG2 . VAL A 1 211 ? 39.608 130.915 -10.256 1.00 227.22 ? 210 VAL A CG2 1 ATOM 1672 N N . HIS A 1 212 ? 41.581 132.626 -6.567 1.00 227.22 ? 211 HIS A N 1 ATOM 1673 C CA . HIS A 1 212 ? 42.158 133.768 -5.885 1.00 227.22 ? 211 HIS A CA 1 ATOM 1674 C C . HIS A 1 212 ? 42.660 133.477 -4.482 1.00 227.22 ? 211 HIS A C 1 ATOM 1675 O O . HIS A 1 212 ? 42.821 134.388 -3.673 1.00 227.22 ? 211 HIS A O 1 ATOM 1676 C CB . HIS A 1 212 ? 41.160 134.921 -5.886 1.00 227.22 ? 211 HIS A CB 1 ATOM 1677 C CG . HIS A 1 212 ? 40.759 135.367 -7.257 1.00 227.22 ? 211 HIS A CG 1 ATOM 1678 N ND1 . HIS A 1 212 ? 41.606 136.065 -8.090 1.00 227.22 ? 211 HIS A ND1 1 ATOM 1679 C CD2 . HIS A 1 212 ? 39.601 135.210 -7.940 1.00 227.22 ? 211 HIS A CD2 1 ATOM 1680 C CE1 . HIS A 1 212 ? 40.983 136.325 -9.225 1.00 227.22 ? 211 HIS A CE1 1 ATOM 1681 N NE2 . HIS A 1 212 ? 39.764 135.821 -9.158 1.00 227.22 ? 211 HIS A NE2 1 ATOM 1682 N N . PHE A 1 213 ? 42.907 132.201 -4.206 1.00 227.22 ? 212 PHE A N 1 ATOM 1683 C CA . PHE A 1 213 ? 43.606 131.804 -2.993 1.00 227.22 ? 212 PHE A CA 1 ATOM 1684 C C . PHE A 1 213 ? 44.508 130.617 -3.267 1.00 227.22 ? 212 PHE A C 1 ATOM 1685 O O . PHE A 1 213 ? 45.729 130.735 -3.187 1.00 227.22 ? 212 PHE A O 1 ATOM 1686 C CB . PHE A 1 213 ? 42.636 131.490 -1.844 1.00 227.22 ? 212 PHE A CB 1 ATOM 1687 C CG . PHE A 1 213 ? 43.297 130.845 -0.649 1.00 227.22 ? 212 PHE A CG 1 ATOM 1688 C CD1 . PHE A 1 213 ? 44.100 131.590 0.210 1.00 227.22 ? 212 PHE A CD1 1 ATOM 1689 C CD2 . PHE A 1 213 ? 43.123 129.489 -0.390 1.00 227.22 ? 212 PHE A CD2 1 ATOM 1690 C CE1 . PHE A 1 213 ? 44.717 130.994 1.309 1.00 227.22 ? 212 PHE A CE1 1 ATOM 1691 C CE2 . PHE A 1 213 ? 43.739 128.882 0.706 1.00 227.22 ? 212 PHE A CE2 1 ATOM 1692 C CZ . PHE A 1 213 ? 44.536 129.637 1.556 1.00 227.22 ? 212 PHE A CZ 1 ATOM 1693 N N . ILE A 1 214 ? 43.901 129.479 -3.593 1.00 227.22 ? 213 ILE A N 1 ATOM 1694 C CA . ILE A 1 214 ? 44.642 128.233 -3.775 1.00 227.22 ? 213 ILE A CA 1 ATOM 1695 C C . ILE A 1 214 ? 45.738 128.406 -4.827 1.00 227.22 ? 213 ILE A C 1 ATOM 1696 O O . ILE A 1 214 ? 46.927 128.295 -4.516 1.00 227.22 ? 213 ILE A O 1 ATOM 1697 C CB . ILE A 1 214 ? 43.715 127.052 -4.179 1.00 227.22 ? 213 ILE A CB 1 ATOM 1698 C CG1 . ILE A 1 214 ? 42.390 127.074 -3.397 1.00 227.22 ? 213 ILE A CG1 1 ATOM 1699 C CG2 . ILE A 1 214 ? 44.451 125.720 -4.040 1.00 227.22 ? 213 ILE A CG2 1 ATOM 1700 C CD1 . ILE A 1 214 ? 42.439 126.480 -1.996 1.00 227.22 ? 213 ILE A CD1 1 ATOM 1701 N N . ILE A 1 215 ? 45.320 128.709 -6.056 1.00 227.22 ? 214 ILE A N 1 ATOM 1702 C CA . ILE A 1 215 ? 46.217 128.827 -7.211 1.00 227.22 ? 214 ILE A CA 1 ATOM 1703 C C . ILE A 1 215 ? 47.412 129.756 -6.970 1.00 227.22 ? 214 ILE A C 1 ATOM 1704 O O . ILE A 1 215 ? 48.556 129.312 -7.085 1.00 227.22 ? 214 ILE A O 1 ATOM 1705 C CB . ILE A 1 215 ? 45.445 129.215 -8.501 1.00 227.22 ? 214 ILE A CB 1 ATOM 1706 C CG1 . ILE A 1 215 ? 44.487 128.088 -8.891 1.00 227.22 ? 214 ILE A CG1 1 ATOM 1707 C CG2 . ILE A 1 215 ? 46.412 129.519 -9.647 1.00 227.22 ? 214 ILE A CG2 1 ATOM 1708 C CD1 . ILE A 1 215 ? 43.356 128.521 -9.798 1.00 227.22 ? 214 ILE A CD1 1 ATOM 1709 N N . PRO A 1 216 ? 47.155 131.030 -6.609 1.00 227.22 ? 215 PRO A N 1 ATOM 1710 C CA . PRO A 1 216 ? 48.268 131.956 -6.424 1.00 227.22 ? 215 PRO A CA 1 ATOM 1711 C C . PRO A 1 216 ? 49.296 131.433 -5.426 1.00 227.22 ? 215 PRO A C 1 ATOM 1712 O O . PRO A 1 216 ? 50.483 131.737 -5.556 1.00 227.22 ? 215 PRO A O 1 ATOM 1713 C CB . PRO A 1 216 ? 47.593 133.210 -5.874 1.00 227.22 ? 215 PRO A CB 1 ATOM 1714 C CG . PRO A 1 216 ? 46.199 133.115 -6.322 1.00 227.22 ? 215 PRO A CG 1 ATOM 1715 C CD . PRO A 1 216 ? 45.860 131.678 -6.340 1.00 227.22 ? 215 PRO A CD 1 ATOM 1716 N N . LEU A 1 217 ? 48.837 130.644 -4.453 1.00 227.22 ? 216 LEU A N 1 ATOM 1717 C CA . LEU A 1 217 ? 49.720 130.053 -3.453 1.00 227.22 ? 216 LEU A CA 1 ATOM 1718 C C . LEU A 1 217 ? 50.585 128.945 -4.020 1.00 227.22 ? 216 LEU A C 1 ATOM 1719 O O . LEU A 1 217 ? 51.757 128.841 -3.667 1.00 227.22 ? 216 LEU A O 1 ATOM 1720 C CB . LEU A 1 217 ? 48.935 129.523 -2.256 1.00 227.22 ? 216 LEU A CB 1 ATOM 1721 C CG . LEU A 1 217 ? 48.354 130.541 -1.281 1.00 227.22 ? 216 LEU A CG 1 ATOM 1722 C CD1 . LEU A 1 217 ? 48.082 129.843 0.042 1.00 227.22 ? 216 LEU A CD1 1 ATOM 1723 C CD2 . LEU A 1 217 ? 49.278 131.742 -1.086 1.00 227.22 ? 216 LEU A CD2 1 ATOM 1724 N N . ILE A 1 218 ? 50.007 128.119 -4.890 1.00 227.22 ? 217 ILE A N 1 ATOM 1725 C CA . ILE A 1 218 ? 50.751 127.032 -5.531 1.00 227.22 ? 217 ILE A CA 1 ATOM 1726 C C . ILE A 1 218 ? 51.840 127.587 -6.451 1.00 227.22 ? 217 ILE A C 1 ATOM 1727 O O . ILE A 1 218 ? 52.909 126.993 -6.578 1.00 227.22 ? 217 ILE A O 1 ATOM 1728 C CB . ILE A 1 218 ? 49.838 126.093 -6.344 1.00 227.22 ? 217 ILE A CB 1 ATOM 1729 C CG1 . ILE A 1 218 ? 48.499 125.887 -5.635 1.00 227.22 ? 217 ILE A CG1 1 ATOM 1730 C CG2 . ILE A 1 218 ? 50.531 124.751 -6.579 1.00 227.22 ? 217 ILE A CG2 1 ATOM 1731 C CD1 . ILE A 1 218 ? 47.366 125.473 -6.563 1.00 227.22 ? 217 ILE A CD1 1 ATOM 1732 N N . VAL A 1 219 ? 51.552 128.722 -7.085 1.00 227.22 ? 218 VAL A N 1 ATOM 1733 C CA . VAL A 1 219 ? 52.520 129.431 -7.920 1.00 227.22 ? 218 VAL A CA 1 ATOM 1734 C C . VAL A 1 219 ? 53.644 130.010 -7.061 1.00 227.22 ? 218 VAL A C 1 ATOM 1735 O O . VAL A 1 219 ? 54.820 129.870 -7.396 1.00 227.22 ? 218 VAL A O 1 ATOM 1736 C CB . VAL A 1 219 ? 51.834 130.552 -8.733 1.00 227.22 ? 218 VAL A CB 1 ATOM 1737 C CG1 . VAL A 1 219 ? 52.859 131.418 -9.450 1.00 227.22 ? 218 VAL A CG1 1 ATOM 1738 C CG2 . VAL A 1 219 ? 50.853 129.954 -9.729 1.00 227.22 ? 218 VAL A CG2 1 ATOM 1739 N N . ILE A 1 220 ? 53.268 130.650 -5.953 1.00 227.22 ? 219 ILE A N 1 ATOM 1740 C CA . ILE A 1 220 ? 54.223 131.230 -5.001 1.00 227.22 ? 219 ILE A CA 1 ATOM 1741 C C . ILE A 1 220 ? 55.006 130.157 -4.238 1.00 227.22 ? 219 ILE A C 1 ATOM 1742 O O . ILE A 1 220 ? 56.171 130.359 -3.880 1.00 227.22 ? 219 ILE A O 1 ATOM 1743 C CB . ILE A 1 220 ? 53.521 132.196 -4.022 1.00 227.22 ? 219 ILE A CB 1 ATOM 1744 C CG1 . ILE A 1 220 ? 53.158 133.498 -4.739 1.00 227.22 ? 219 ILE A CG1 1 ATOM 1745 C CG2 . ILE A 1 220 ? 54.394 132.488 -2.803 1.00 227.22 ? 219 ILE A CG2 1 ATOM 1746 C CD1 . ILE A 1 220 ? 52.237 134.393 -3.943 1.00 227.22 ? 219 ILE A CD1 1 ATOM 1747 N N . PHE A 1 221 ? 54.358 129.023 -3.993 1.00 227.22 ? 220 PHE A N 1 ATOM 1748 C CA . PHE A 1 221 ? 55.035 127.844 -3.469 1.00 227.22 ? 220 PHE A CA 1 ATOM 1749 C C . PHE A 1 221 ? 55.945 127.230 -4.541 1.00 227.22 ? 220 PHE A C 1 ATOM 1750 O O . PHE A 1 221 ? 57.019 126.707 -4.228 1.00 227.22 ? 220 PHE A O 1 ATOM 1751 C CB . PHE A 1 221 ? 54.008 126.821 -2.964 1.00 227.22 ? 220 PHE A CB 1 ATOM 1752 C CG . PHE A 1 221 ? 54.599 125.485 -2.598 1.00 227.22 ? 220 PHE A CG 1 ATOM 1753 C CD1 . PHE A 1 221 ? 55.336 125.329 -1.425 1.00 227.22 ? 220 PHE A CD1 1 ATOM 1754 C CD2 . PHE A 1 221 ? 54.409 124.376 -3.426 1.00 227.22 ? 220 PHE A CD2 1 ATOM 1755 C CE1 . PHE A 1 221 ? 55.884 124.086 -1.086 1.00 227.22 ? 220 PHE A CE1 1 ATOM 1756 C CE2 . PHE A 1 221 ? 54.953 123.128 -3.096 1.00 227.22 ? 220 PHE A CE2 1 ATOM 1757 C CZ . PHE A 1 221 ? 55.691 122.983 -1.924 1.00 227.22 ? 220 PHE A CZ 1 ATOM 1758 N N . PHE A 1 222 ? 55.503 127.305 -5.799 1.00 227.22 ? 221 PHE A N 1 ATOM 1759 C CA . PHE A 1 222 ? 56.269 126.805 -6.946 1.00 227.22 ? 221 PHE A CA 1 ATOM 1760 C C . PHE A 1 222 ? 57.586 127.567 -7.106 1.00 227.22 ? 221 PHE A C 1 ATOM 1761 O O . PHE A 1 222 ? 58.665 126.967 -7.067 1.00 227.22 ? 221 PHE A O 1 ATOM 1762 C CB . PHE A 1 222 ? 55.434 126.889 -8.234 1.00 227.22 ? 221 PHE A CB 1 ATOM 1763 C CG . PHE A 1 222 ? 56.107 126.292 -9.439 1.00 227.22 ? 221 PHE A CG 1 ATOM 1764 C CD1 . PHE A 1 222 ? 55.846 124.977 -9.815 1.00 227.22 ? 221 PHE A CD1 1 ATOM 1765 C CD2 . PHE A 1 222 ? 56.999 127.047 -10.201 1.00 227.22 ? 221 PHE A CD2 1 ATOM 1766 C CE1 . PHE A 1 222 ? 56.467 124.416 -10.931 1.00 227.22 ? 221 PHE A CE1 1 ATOM 1767 C CE2 . PHE A 1 222 ? 57.628 126.498 -11.316 1.00 227.22 ? 221 PHE A CE2 1 ATOM 1768 C CZ . PHE A 1 222 ? 57.359 125.178 -11.683 1.00 227.22 ? 221 PHE A CZ 1 ATOM 1769 N N . CYS A 1 223 ? 57.486 128.885 -7.282 1.00 227.22 ? 222 CYS A N 1 ATOM 1770 C CA . CYS A 1 223 ? 58.652 129.766 -7.380 1.00 227.22 ? 222 CYS A CA 1 ATOM 1771 C C . CYS A 1 223 ? 59.592 129.605 -6.183 1.00 227.22 ? 222 CYS A C 1 ATOM 1772 O O . CYS A 1 223 ? 60.804 129.808 -6.298 1.00 227.22 ? 222 CYS A O 1 ATOM 1773 C CB . CYS A 1 223 ? 58.208 131.224 -7.494 1.00 227.22 ? 222 CYS A CB 1 ATOM 1774 S SG . CYS A 1 223 ? 57.114 131.590 -8.889 1.00 227.22 ? 222 CYS A SG 1 ATOM 1775 N N . TYR A 1 224 ? 59.015 129.246 -5.039 1.00 227.22 ? 223 TYR A N 1 ATOM 1776 C CA . TYR A 1 224 ? 59.773 128.913 -3.842 1.00 227.22 ? 223 TYR A CA 1 ATOM 1777 C C . TYR A 1 224 ? 60.585 127.639 -4.075 1.00 227.22 ? 223 TYR A C 1 ATOM 1778 O O . TYR A 1 224 ? 61.784 127.609 -3.799 1.00 227.22 ? 223 TYR A O 1 ATOM 1779 C CB . TYR A 1 224 ? 58.822 128.749 -2.652 1.00 227.22 ? 223 TYR A CB 1 ATOM 1780 C CG . TYR A 1 224 ? 59.483 128.500 -1.310 1.00 227.22 ? 223 TYR A CG 1 ATOM 1781 C CD1 . TYR A 1 224 ? 59.563 127.211 -0.778 1.00 227.22 ? 223 TYR A CD1 1 ATOM 1782 C CD2 . TYR A 1 224 ? 60.004 129.555 -0.561 1.00 227.22 ? 223 TYR A CD2 1 ATOM 1783 C CE1 . TYR A 1 224 ? 60.157 126.978 0.460 1.00 227.22 ? 223 TYR A CE1 1 ATOM 1784 C CE2 . TYR A 1 224 ? 60.601 129.335 0.675 1.00 227.22 ? 223 TYR A CE2 1 ATOM 1785 C CZ . TYR A 1 224 ? 60.674 128.044 1.180 1.00 227.22 ? 223 TYR A CZ 1 ATOM 1786 O OH . TYR A 1 224 ? 61.261 127.820 2.406 1.00 227.22 ? 223 TYR A OH 1 ATOM 1787 N N . GLY A 1 225 ? 59.930 126.609 -4.613 1.00 227.22 ? 224 GLY A N 1 ATOM 1788 C CA . GLY A 1 225 ? 60.545 125.291 -4.827 1.00 227.22 ? 224 GLY A CA 1 ATOM 1789 C C . GLY A 1 225 ? 61.777 125.279 -5.714 1.00 227.22 ? 224 GLY A C 1 ATOM 1790 O O . GLY A 1 225 ? 62.631 124.398 -5.595 1.00 227.22 ? 224 GLY A O 1 ATOM 1791 N N . GLN A 1 226 ? 61.863 126.260 -6.605 1.00 227.22 ? 225 GLN A N 1 ATOM 1792 C CA . GLN A 1 226 ? 63.002 126.396 -7.508 1.00 227.22 ? 225 GLN A CA 1 ATOM 1793 C C . GLN A 1 226 ? 64.128 127.187 -6.860 1.00 227.22 ? 225 GLN A C 1 ATOM 1794 O O . GLN A 1 226 ? 65.300 126.935 -7.133 1.00 227.22 ? 225 GLN A O 1 ATOM 1795 C CB . GLN A 1 226 ? 62.577 127.069 -8.817 1.00 227.22 ? 225 GLN A CB 1 ATOM 1796 C CG . GLN A 1 226 ? 61.671 126.214 -9.711 1.00 227.22 ? 225 GLN A CG 1 ATOM 1797 C CD . GLN A 1 226 ? 62.391 125.026 -10.325 1.00 227.22 ? 225 GLN A CD 1 ATOM 1798 O OE1 . GLN A 1 226 ? 61.957 123.883 -10.175 1.00 227.22 ? 225 GLN A OE1 1 ATOM 1799 N NE2 . GLN A 1 226 ? 63.502 125.288 -11.011 1.00 227.22 ? 225 GLN A NE2 1 ATOM 1800 N N . LEU A 1 227 ? 63.757 128.146 -6.012 1.00 227.22 ? 226 LEU A N 1 ATOM 1801 C CA . LEU A 1 227 ? 64.720 128.980 -5.289 1.00 227.22 ? 226 LEU A CA 1 ATOM 1802 C C . LEU A 1 227 ? 65.459 128.219 -4.192 1.00 227.22 ? 226 LEU A C 1 ATOM 1803 O O . LEU A 1 227 ? 66.629 128.500 -3.917 1.00 227.22 ? 226 LEU A O 1 ATOM 1804 C CB . LEU A 1 227 ? 64.036 130.217 -4.704 1.00 227.22 ? 226 LEU A CB 1 ATOM 1805 C CG . LEU A 1 227 ? 64.278 131.530 -5.445 1.00 227.22 ? 226 LEU A CG 1 ATOM 1806 C CD1 . LEU A 1 227 ? 63.145 132.518 -5.196 1.00 227.22 ? 226 LEU A CD1 1 ATOM 1807 C CD2 . LEU A 1 227 ? 65.634 132.124 -5.064 1.00 227.22 ? 226 LEU A CD2 1 ATOM 1808 N N . VAL A 1 228 ? 64.765 127.267 -3.566 1.00 227.22 ? 227 VAL A N 1 ATOM 1809 C CA . VAL A 1 228 ? 65.382 126.318 -2.638 1.00 227.22 ? 227 VAL A CA 1 ATOM 1810 C C . VAL A 1 228 ? 66.387 125.466 -3.422 1.00 227.22 ? 227 VAL A C 1 ATOM 1811 O O . VAL A 1 228 ? 67.502 125.197 -2.959 1.00 227.22 ? 227 VAL A O 1 ATOM 1812 C CB . VAL A 1 228 ? 64.317 125.396 -1.975 1.00 227.22 ? 227 VAL A CB 1 ATOM 1813 C CG1 . VAL A 1 228 ? 64.942 124.531 -0.877 1.00 227.22 ? 227 VAL A CG1 1 ATOM 1814 C CG2 . VAL A 1 228 ? 63.160 126.211 -1.409 1.00 227.22 ? 227 VAL A CG2 1 ATOM 1815 N N . PHE A 1 229 ? 65.973 125.067 -4.624 1.00 227.22 ? 228 PHE A N 1 ATOM 1816 C CA . PHE A 1 229 ? 66.799 124.283 -5.539 1.00 227.22 ? 228 PHE A CA 1 ATOM 1817 C C . PHE A 1 229 ? 68.005 125.077 -6.058 1.00 227.22 ? 228 PHE A C 1 ATOM 1818 O O . PHE A 1 229 ? 69.131 124.574 -6.055 1.00 227.22 ? 228 PHE A O 1 ATOM 1819 C CB . PHE A 1 229 ? 65.950 123.783 -6.717 1.00 227.22 ? 228 PHE A CB 1 ATOM 1820 C CG . PHE A 1 229 ? 66.432 122.484 -7.306 1.00 227.22 ? 228 PHE A CG 1 ATOM 1821 C CD1 . PHE A 1 229 ? 65.786 121.285 -6.999 1.00 227.22 ? 228 PHE A CD1 1 ATOM 1822 C CD2 . PHE A 1 229 ? 67.532 122.456 -8.164 1.00 227.22 ? 228 PHE A CD2 1 ATOM 1823 C CE1 . PHE A 1 229 ? 66.225 120.076 -7.538 1.00 227.22 ? 228 PHE A CE1 1 ATOM 1824 C CE2 . PHE A 1 229 ? 67.980 121.253 -8.708 1.00 227.22 ? 228 PHE A CE2 1 ATOM 1825 C CZ . PHE A 1 229 ? 67.324 120.060 -8.394 1.00 227.22 ? 228 PHE A CZ 1 ATOM 1826 N N . THR A 1 230 ? 67.758 126.311 -6.497 1.00 227.22 ? 229 THR A N 1 ATOM 1827 C CA . THR A 1 230 ? 68.806 127.169 -7.045 1.00 227.22 ? 229 THR A CA 1 ATOM 1828 C C . THR A 1 230 ? 69.924 127.439 -6.028 1.00 227.22 ? 229 THR A C 1 ATOM 1829 O O . THR A 1 230 ? 71.037 126.952 -6.202 1.00 227.22 ? 229 THR A O 1 ATOM 1830 C CB . THR A 1 230 ? 68.226 128.481 -7.637 1.00 227.22 ? 229 THR A CB 1 ATOM 1831 O OG1 . THR A 1 230 ? 67.107 128.169 -8.478 1.00 227.22 ? 229 THR A OG1 1 ATOM 1832 C CG2 . THR A 1 230 ? 69.274 129.226 -8.464 1.00 227.22 ? 229 THR A CG2 1 ATOM 1833 N N . VAL A 1 231 ? 69.615 128.170 -4.957 1.00 227.22 ? 230 VAL A N 1 ATOM 1834 C CA . VAL A 1 231 ? 70.614 128.599 -3.947 1.00 227.22 ? 230 VAL A CA 1 ATOM 1835 C C . VAL A 1 231 ? 71.483 127.471 -3.344 1.00 227.22 ? 230 VAL A C 1 ATOM 1836 O O . VAL A 1 231 ? 72.627 127.706 -2.926 1.00 227.22 ? 230 VAL A O 1 ATOM 1837 C CB . VAL A 1 231 ? 69.957 129.490 -2.836 1.00 227.22 ? 230 VAL A CB 1 ATOM 1838 C CG1 . VAL A 1 231 ? 70.894 129.721 -1.644 1.00 227.22 ? 230 VAL A CG1 1 ATOM 1839 C CG2 . VAL A 1 231 ? 69.512 130.828 -3.429 1.00 227.22 ? 230 VAL A CG2 1 ATOM 1840 N N . LYS A 1 232 ? 70.947 126.252 -3.319 1.00 227.22 ? 231 LYS A N 1 ATOM 1841 C CA . LYS A 1 232 ? 71.711 125.090 -2.877 1.00 227.22 ? 231 LYS A CA 1 ATOM 1842 C C . LYS A 1 232 ? 72.829 124.732 -3.875 1.00 227.22 ? 231 LYS A C 1 ATOM 1843 O O . LYS A 1 232 ? 74.016 124.936 -3.578 1.00 227.22 ? 231 LYS A O 1 ATOM 1844 C CB . LYS A 1 232 ? 70.767 123.903 -2.597 1.00 227.22 ? 231 LYS A CB 1 ATOM 1845 C CG . LYS A 1 232 ? 71.431 122.534 -2.366 1.00 227.22 ? 231 LYS A CG 1 ATOM 1846 C CD . LYS A 1 232 ? 72.562 122.557 -1.334 1.00 227.22 ? 231 LYS A CD 1 ATOM 1847 C CE . LYS A 1 232 ? 73.362 121.256 -1.381 1.00 227.22 ? 231 LYS A CE 1 ATOM 1848 N NZ . LYS A 1 232 ? 74.771 121.431 -0.926 1.00 227.22 ? 231 LYS A NZ 1 ATOM 1849 N N . GLU A 1 233 ? 72.436 124.242 -5.055 1.00 227.22 ? 232 GLU A N 1 ATOM 1850 C CA . GLU A 1 233 ? 73.356 123.620 -6.021 1.00 227.22 ? 232 GLU A CA 1 ATOM 1851 C C . GLU A 1 233 ? 73.132 124.071 -7.483 1.00 227.22 ? 232 GLU A C 1 ATOM 1852 O O . GLU A 1 233 ? 73.978 123.820 -8.354 1.00 227.22 ? 232 GLU A O 1 ATOM 1853 C CB . GLU A 1 233 ? 73.237 122.097 -5.914 1.00 227.22 ? 232 GLU A CB 1 ATOM 1854 C CG . GLU A 1 233 ? 74.484 121.318 -6.292 1.00 227.22 ? 232 GLU A CG 1 ATOM 1855 C CD . GLU A 1 233 ? 74.221 119.818 -6.379 1.00 227.22 ? 232 GLU A CD 1 ATOM 1856 O OE1 . GLU A 1 233 ? 73.020 119.421 -6.216 1.00 227.22 ? 232 GLU A OE1 1 ATOM 1857 O OE2 . GLU A 1 233 ? 75.219 119.032 -6.610 1.00 227.22 ? 232 GLU A OE2 1 ATOM 1858 N N . ALA A 1 234 ? 71.997 124.726 -7.743 1.00 227.22 ? 233 ALA A N 1 ATOM 1859 C CA . ALA A 1 234 ? 71.694 125.288 -9.067 1.00 227.22 ? 233 ALA A CA 1 ATOM 1860 C C . ALA A 1 234 ? 72.041 126.790 -9.161 1.00 227.22 ? 233 ALA A C 1 ATOM 1861 O O . ALA A 1 234 ? 71.757 127.450 -10.174 1.00 227.22 ? 233 ALA A O 1 ATOM 1862 C CB . ALA A 1 234 ? 70.229 125.023 -9.446 1.00 227.22 ? 233 ALA A CB 1 ATOM 1863 N N . ALA A 1 235 ? 72.648 127.313 -8.091 1.00 227.22 ? 234 ALA A N 1 ATOM 1864 C CA . ALA A 1 235 ? 73.248 128.654 -8.077 1.00 227.22 ? 234 ALA A CA 1 ATOM 1865 C C . ALA A 1 235 ? 74.751 128.568 -7.767 1.00 227.22 ? 234 ALA A C 1 ATOM 1866 O O . ALA A 1 235 ? 75.382 129.561 -7.367 1.00 227.22 ? 234 ALA A O 1 ATOM 1867 C CB . ALA A 1 235 ? 72.530 129.575 -7.087 1.00 227.22 ? 234 ALA A CB 1 ATOM 1868 N N . ALA A 1 236 ? 75.307 127.370 -7.962 1.00 227.22 ? 235 ALA A N 1 ATOM 1869 C CA . ALA A 1 236 ? 76.748 127.127 -7.865 1.00 227.22 ? 235 ALA A CA 1 ATOM 1870 C C . ALA A 1 236 ? 77.453 127.343 -9.219 1.00 227.22 ? 235 ALA A C 1 ATOM 1871 O O . ALA A 1 236 ? 78.415 128.123 -9.311 1.00 227.22 ? 235 ALA A O 1 ATOM 1872 C CB . ALA A 1 236 ? 77.015 125.717 -7.325 1.00 227.22 ? 235 ALA A CB 1 ATOM 1873 N N . GLN A 1 237 ? 76.959 126.657 -10.258 1.00 227.22 ? 236 GLN A N 1 ATOM 1874 C CA . GLN A 1 237 ? 77.489 126.760 -11.633 1.00 227.22 ? 236 GLN A CA 1 ATOM 1875 C C . GLN A 1 237 ? 77.081 128.071 -12.324 1.00 227.22 ? 236 GLN A C 1 ATOM 1876 O O . GLN A 1 237 ? 77.764 128.527 -13.247 1.00 227.22 ? 236 GLN A O 1 ATOM 1877 C CB . GLN A 1 237 ? 77.051 125.553 -12.483 1.00 227.22 ? 236 GLN A CB 1 ATOM 1878 C CG . GLN A 1 237 ? 77.732 124.226 -12.126 1.00 227.22 ? 236 GLN A CG 1 ATOM 1879 C CD . GLN A 1 237 ? 76.892 123.000 -12.488 1.00 227.22 ? 236 GLN A CD 1 ATOM 1880 O OE1 . GLN A 1 237 ? 75.799 123.114 -13.052 1.00 227.22 ? 236 GLN A OE1 1 ATOM 1881 N NE2 . GLN A 1 237 ? 77.405 121.817 -12.154 1.00 227.22 ? 236 GLN A NE2 1 ATOM 1882 N N . GLN A 1 238 ? 75.973 128.659 -11.868 1.00 227.22 ? 237 GLN A N 1 ATOM 1883 C CA . GLN A 1 238 ? 75.484 129.955 -12.354 1.00 227.22 ? 237 GLN A CA 1 ATOM 1884 C C . GLN A 1 238 ? 76.453 131.117 -12.102 1.00 227.22 ? 237 GLN A C 1 ATOM 1885 O O . GLN A 1 238 ? 76.302 132.197 -12.692 1.00 227.22 ? 237 GLN A O 1 ATOM 1886 C CB . GLN A 1 238 ? 74.116 130.265 -11.746 1.00 227.22 ? 237 GLN A CB 1 ATOM 1887 C CG . GLN A 1 238 ? 72.970 129.582 -12.463 1.00 227.22 ? 237 GLN A CG 1 ATOM 1888 C CD . GLN A 1 238 ? 72.793 130.091 -13.884 1.00 227.22 ? 237 GLN A CD 1 ATOM 1889 O OE1 . GLN A 1 238 ? 72.689 131.304 -14.116 1.00 227.22 ? 237 GLN A OE1 1 ATOM 1890 N NE2 . GLN A 1 238 ? 72.757 129.166 -14.846 1.00 227.22 ? 237 GLN A NE2 1 ATOM 1891 N N . GLN A 1 239 ? 77.420 130.884 -11.210 1.00 227.22 ? 238 GLN A N 1 ATOM 1892 C CA . GLN A 1 239 ? 78.596 131.754 -10.994 1.00 227.22 ? 238 GLN A CA 1 ATOM 1893 C C . GLN A 1 239 ? 78.354 133.132 -10.353 1.00 227.22 ? 238 GLN A C 1 ATOM 1894 O O . GLN A 1 239 ? 79.323 133.837 -10.033 1.00 227.22 ? 238 GLN A O 1 ATOM 1895 C CB . GLN A 1 239 ? 79.423 131.900 -12.285 1.00 227.22 ? 238 GLN A CB 1 ATOM 1896 C CG . GLN A 1 239 ? 80.247 130.670 -12.635 1.00 227.22 ? 238 GLN A CG 1 ATOM 1897 C CD . GLN A 1 239 ? 81.197 130.913 -13.787 1.00 227.22 ? 238 GLN A CD 1 ATOM 1898 O OE1 . GLN A 1 239 ? 82.098 131.755 -13.707 1.00 227.22 ? 238 GLN A OE1 1 ATOM 1899 N NE2 . GLN A 1 239 ? 81.008 130.164 -14.868 1.00 227.22 ? 238 GLN A NE2 1 ATOM 1900 N N . GLU A 1 240 ? 77.083 133.503 -10.163 1.00 227.22 ? 239 GLU A N 1 ATOM 1901 C CA . GLU A 1 240 ? 76.709 134.786 -9.556 1.00 227.22 ? 239 GLU A CA 1 ATOM 1902 C C . GLU A 1 240 ? 77.742 135.217 -8.511 1.00 227.22 ? 239 GLU A C 1 ATOM 1903 O O . GLU A 1 240 ? 78.039 134.459 -7.578 1.00 227.22 ? 239 GLU A O 1 ATOM 1904 C CB . GLU A 1 240 ? 75.325 134.687 -8.905 1.00 227.22 ? 239 GLU A CB 1 ATOM 1905 C CG . GLU A 1 240 ? 74.182 134.388 -9.857 1.00 227.22 ? 239 GLU A CG 1 ATOM 1906 C CD . GLU A 1 240 ? 73.068 133.602 -9.193 1.00 227.22 ? 239 GLU A CD 1 ATOM 1907 O OE1 . GLU A 1 240 ? 73.308 132.398 -8.876 1.00 227.22 ? 239 GLU A OE1 1 ATOM 1908 O OE2 . GLU A 1 240 ? 71.952 134.184 -8.994 1.00 227.22 ? 239 GLU A OE2 1 ATOM 1909 N N . SER A 1 241 ? 78.311 136.411 -8.682 1.00 227.22 ? 240 SER A N 1 ATOM 1910 C CA . SER A 1 241 ? 79.268 136.945 -7.704 1.00 227.22 ? 240 SER A CA 1 ATOM 1911 C C . SER A 1 241 ? 78.569 137.184 -6.351 1.00 227.22 ? 240 SER A C 1 ATOM 1912 O O . SER A 1 241 ? 77.404 137.607 -6.318 1.00 227.22 ? 240 SER A O 1 ATOM 1913 C CB . SER A 1 241 ? 79.966 138.214 -8.227 1.00 227.22 ? 240 SER A CB 1 ATOM 1914 O OG . SER A 1 241 ? 79.047 139.259 -8.498 1.00 227.22 ? 240 SER A OG 1 ATOM 1915 N N . ALA A 1 242 ? 79.275 136.883 -5.255 1.00 227.22 ? 241 ALA A N 1 ATOM 1916 C CA . ALA A 1 242 ? 78.726 136.967 -3.889 1.00 227.22 ? 241 ALA A CA 1 ATOM 1917 C C . ALA A 1 242 ? 78.185 138.356 -3.505 1.00 227.22 ? 241 ALA A C 1 ATOM 1918 O O . ALA A 1 242 ? 77.177 138.463 -2.795 1.00 227.22 ? 241 ALA A O 1 ATOM 1919 C CB . ALA A 1 242 ? 79.762 136.486 -2.872 1.00 227.22 ? 241 ALA A CB 1 ATOM 1920 N N . THR A 1 243 ? 78.868 139.403 -3.976 1.00 227.22 ? 242 THR A N 1 ATOM 1921 C CA . THR A 1 243 ? 78.404 140.791 -3.854 1.00 227.22 ? 242 THR A CA 1 ATOM 1922 C C . THR A 1 243 ? 76.959 140.918 -4.367 1.00 227.22 ? 242 THR A C 1 ATOM 1923 O O . THR A 1 243 ? 76.080 141.438 -3.660 1.00 227.22 ? 242 THR A O 1 ATOM 1924 C CB . THR A 1 243 ? 79.337 141.771 -4.636 1.00 227.22 ? 242 THR A CB 1 ATOM 1925 O OG1 . THR A 1 243 ? 80.709 141.396 -4.456 1.00 227.22 ? 242 THR A OG1 1 ATOM 1926 C CG2 . THR A 1 243 ? 79.142 143.215 -4.177 1.00 227.22 ? 242 THR A CG2 1 ATOM 1927 N N . THR A 1 244 ? 76.739 140.425 -5.594 1.00 227.22 ? 243 THR A N 1 ATOM 1928 C CA . THR A 1 244 ? 75.425 140.386 -6.260 1.00 227.22 ? 243 THR A CA 1 ATOM 1929 C C . THR A 1 244 ? 74.402 139.632 -5.410 1.00 227.22 ? 243 THR A C 1 ATOM 1930 O O . THR A 1 244 ? 73.299 140.132 -5.178 1.00 227.22 ? 243 THR A O 1 ATOM 1931 C CB . THR A 1 244 ? 75.521 139.727 -7.677 1.00 227.22 ? 243 THR A CB 1 ATOM 1932 O OG1 . THR A 1 244 ? 76.594 140.320 -8.421 1.00 227.22 ? 243 THR A OG1 1 ATOM 1933 C CG2 . THR A 1 244 ? 74.211 139.875 -8.458 1.00 227.22 ? 243 THR A CG2 1 ATOM 1934 N N . GLN A 1 245 ? 74.791 138.442 -4.947 1.00 227.22 ? 244 GLN A N 1 ATOM 1935 C CA . GLN A 1 245 ? 73.963 137.612 -4.072 1.00 227.22 ? 244 GLN A CA 1 ATOM 1936 C C . GLN A 1 245 ? 73.551 138.348 -2.790 1.00 227.22 ? 244 GLN A C 1 ATOM 1937 O O . GLN A 1 245 ? 72.363 138.396 -2.464 1.00 227.22 ? 244 GLN A O 1 ATOM 1938 C CB . GLN A 1 245 ? 74.687 136.309 -3.707 1.00 227.22 ? 244 GLN A CB 1 ATOM 1939 C CG . GLN A 1 245 ? 74.867 135.327 -4.845 1.00 227.22 ? 244 GLN A CG 1 ATOM 1940 C CD . GLN A 1 245 ? 75.263 133.942 -4.363 1.00 227.22 ? 244 GLN A CD 1 ATOM 1941 O OE1 . GLN A 1 245 ? 74.417 133.158 -3.929 1.00 227.22 ? 244 GLN A OE1 1 ATOM 1942 N NE2 . GLN A 1 245 ? 76.555 133.629 -4.452 1.00 227.22 ? 244 GLN A NE2 1 ATOM 1943 N N . LYS A 1 246 ? 74.531 138.923 -2.084 1.00 227.22 ? 245 LYS A N 1 ATOM 1944 C CA . LYS A 1 246 ? 74.309 139.581 -0.789 1.00 227.22 ? 245 LYS A CA 1 ATOM 1945 C C . LYS A 1 246 ? 73.088 140.492 -0.817 1.00 227.22 ? 245 LYS A C 1 ATOM 1946 O O . LYS A 1 246 ? 72.129 140.280 -0.069 1.00 227.22 ? 245 LYS A O 1 ATOM 1947 C CB . LYS A 1 246 ? 75.549 140.377 -0.367 1.00 227.22 ? 245 LYS A CB 1 ATOM 1948 C CG . LYS A 1 246 ? 75.569 140.796 1.109 1.00 227.22 ? 245 LYS A CG 1 ATOM 1949 C CD . LYS A 1 246 ? 76.553 141.954 1.375 1.00 227.22 ? 245 LYS A CD 1 ATOM 1950 C CE . LYS A 1 246 ? 78.023 141.614 0.997 1.00 227.22 ? 245 LYS A CE 1 ATOM 1951 N NZ . LYS A 1 246 ? 78.603 140.432 1.749 1.00 227.22 ? 245 LYS A NZ 1 ATOM 1952 N N . ALA A 1 247 ? 73.127 141.491 -1.696 1.00 227.22 ? 246 ALA A N 1 ATOM 1953 C CA . ALA A 1 247 ? 72.029 142.445 -1.831 1.00 227.22 ? 246 ALA A CA 1 ATOM 1954 C C . ALA A 1 247 ? 70.774 141.822 -2.458 1.00 227.22 ? 246 ALA A C 1 ATOM 1955 O O . ALA A 1 247 ? 69.650 142.178 -2.079 1.00 227.22 ? 246 ALA A O 1 ATOM 1956 C CB . ALA A 1 247 ? 72.481 143.674 -2.613 1.00 227.22 ? 246 ALA A CB 1 ATOM 1957 N N . GLU A 1 248 ? 70.972 140.898 -3.405 1.00 227.22 ? 247 GLU A N 1 ATOM 1958 C CA . GLU A 1 248 ? 69.862 140.193 -4.068 1.00 227.22 ? 247 GLU A CA 1 ATOM 1959 C C . GLU A 1 248 ? 69.170 139.202 -3.140 1.00 227.22 ? 247 GLU A C 1 ATOM 1960 O O . GLU A 1 248 ? 67.989 138.898 -3.320 1.00 227.22 ? 247 GLU A O 1 ATOM 1961 C CB . GLU A 1 248 ? 70.317 139.490 -5.355 1.00 227.22 ? 247 GLU A CB 1 ATOM 1962 C CG . GLU A 1 248 ? 70.572 140.429 -6.537 1.00 227.22 ? 247 GLU A CG 1 ATOM 1963 C CD . GLU A 1 248 ? 69.295 141.015 -7.134 1.00 227.22 ? 247 GLU A CD 1 ATOM 1964 O OE1 . GLU A 1 248 ? 68.612 141.814 -6.455 1.00 227.22 ? 247 GLU A OE1 1 ATOM 1965 O OE2 . GLU A 1 248 ? 68.984 140.689 -8.301 1.00 227.22 ? 247 GLU A OE2 1 ATOM 1966 N N . LYS A 1 249 ? 69.910 138.700 -2.154 1.00 227.22 ? 248 LYS A N 1 ATOM 1967 C CA . LYS A 1 249 ? 69.331 137.838 -1.138 1.00 227.22 ? 248 LYS A CA 1 ATOM 1968 C C . LYS A 1 249 ? 68.419 138.692 -0.257 1.00 227.22 ? 248 LYS A C 1 ATOM 1969 O O . LYS A 1 249 ? 67.274 138.310 0.005 1.00 227.22 ? 248 LYS A O 1 ATOM 1970 C CB . LYS A 1 249 ? 70.417 137.128 -0.321 1.00 227.22 ? 248 LYS A CB 1 ATOM 1971 C CG . LYS A 1 249 ? 70.156 135.629 -0.104 1.00 227.22 ? 248 LYS A CG 1 ATOM 1972 C CD . LYS A 1 249 ? 71.121 134.991 0.905 1.00 227.22 ? 248 LYS A CD 1 ATOM 1973 C CE . LYS A 1 249 ? 72.520 134.740 0.330 1.00 227.22 ? 248 LYS A CE 1 ATOM 1974 N NZ . LYS A 1 249 ? 73.460 135.886 0.523 1.00 227.22 ? 248 LYS A NZ 1 ATOM 1975 N N . GLU A 1 250 ? 68.912 139.864 0.155 1.00 227.22 ? 249 GLU A N 1 ATOM 1976 C CA . GLU A 1 250 ? 68.125 140.820 0.946 1.00 227.22 ? 249 GLU A CA 1 ATOM 1977 C C . GLU A 1 250 ? 66.851 141.243 0.188 1.00 227.22 ? 249 GLU A C 1 ATOM 1978 O O . GLU A 1 250 ? 65.969 141.918 0.741 1.00 227.22 ? 249 GLU A O 1 ATOM 1979 C CB . GLU A 1 250 ? 68.979 142.043 1.309 1.00 227.22 ? 249 GLU A CB 1 ATOM 1980 C CG . GLU A 1 250 ? 68.571 142.761 2.599 1.00 227.22 ? 249 GLU A CG 1 ATOM 1981 C CD . GLU A 1 250 ? 68.680 144.281 2.485 1.00 227.22 ? 249 GLU A CD 1 ATOM 1982 O OE1 . GLU A 1 250 ? 67.792 144.901 1.852 1.00 227.22 ? 249 GLU A OE1 1 ATOM 1983 O OE2 . GLU A 1 250 ? 69.646 144.859 3.034 1.00 227.22 ? 249 GLU A OE2 1 ATOM 1984 N N . VAL A 1 251 ? 66.768 140.824 -1.077 1.00 227.22 ? 250 VAL A N 1 ATOM 1985 C CA . VAL A 1 251 ? 65.613 141.074 -1.945 1.00 227.22 ? 250 VAL A CA 1 ATOM 1986 C C . VAL A 1 251 ? 64.779 139.794 -2.150 1.00 227.22 ? 250 VAL A C 1 ATOM 1987 O O . VAL A 1 251 ? 63.586 139.857 -2.459 1.00 227.22 ? 250 VAL A O 1 ATOM 1988 C CB . VAL A 1 251 ? 66.059 141.699 -3.302 1.00 227.22 ? 250 VAL A CB 1 ATOM 1989 C CG1 . VAL A 1 251 ? 64.887 141.838 -4.266 1.00 227.22 ? 250 VAL A CG1 1 ATOM 1990 C CG2 . VAL A 1 251 ? 66.727 143.059 -3.077 1.00 227.22 ? 250 VAL A CG2 1 ATOM 1991 N N . THR A 1 252 ? 65.414 138.638 -1.972 1.00 227.22 ? 251 THR A N 1 ATOM 1992 C CA . THR A 1 252 ? 64.707 137.364 -1.986 1.00 227.22 ? 251 THR A CA 1 ATOM 1993 C C . THR A 1 252 ? 63.886 137.257 -0.719 1.00 227.22 ? 251 THR A C 1 ATOM 1994 O O . THR A 1 252 ? 62.684 136.979 -0.768 1.00 227.22 ? 251 THR A O 1 ATOM 1995 C CB . THR A 1 252 ? 65.673 136.169 -1.981 1.00 227.22 ? 251 THR A CB 1 ATOM 1996 O OG1 . THR A 1 252 ? 66.836 136.474 -2.756 1.00 227.22 ? 251 THR A OG1 1 ATOM 1997 C CG2 . THR A 1 252 ? 64.987 134.922 -2.527 1.00 227.22 ? 251 THR A CG2 1 ATOM 1998 N N . ARG A 1 253 ? 64.567 137.474 0.410 1.00 227.22 ? 252 ARG A N 1 ATOM 1999 C CA . ARG A 1 253 ? 64.000 137.338 1.753 1.00 227.22 ? 252 ARG A CA 1 ATOM 2000 C C . ARG A 1 253 ? 62.748 138.195 1.877 1.00 227.22 ? 252 ARG A C 1 ATOM 2001 O O . ARG A 1 253 ? 61.672 137.710 2.259 1.00 227.22 ? 252 ARG A O 1 ATOM 2002 C CB . ARG A 1 253 ? 65.038 137.741 2.815 1.00 227.22 ? 252 ARG A CB 1 ATOM 2003 C CG . ARG A 1 253 ? 66.292 136.856 2.863 1.00 227.22 ? 252 ARG A CG 1 ATOM 2004 C CD . ARG A 1 253 ? 67.117 137.079 4.143 1.00 227.22 ? 252 ARG A CD 1 ATOM 2005 N NE . ARG A 1 253 ? 68.094 138.175 4.048 1.00 227.22 ? 252 ARG A NE 1 ATOM 2006 C CZ . ARG A 1 253 ? 69.423 138.006 4.010 1.00 227.22 ? 252 ARG A CZ 1 ATOM 2007 N NH1 . ARG A 1 253 ? 69.977 136.774 4.051 1.00 227.22 ? 252 ARG A NH1 1 ATOM 2008 N NH2 . ARG A 1 253 ? 70.207 139.080 3.927 1.00 227.22 ? 252 ARG A NH2 1 ATOM 2009 N N . MET A 1 254 ? 62.908 139.465 1.513 1.00 227.22 ? 253 MET A N 1 ATOM 2010 C CA . MET A 1 254 ? 61.836 140.442 1.538 1.00 227.22 ? 253 MET A CA 1 ATOM 2011 C C . MET A 1 254 ? 60.543 139.929 0.896 1.00 227.22 ? 253 MET A C 1 ATOM 2012 O O . MET A 1 254 ? 59.457 140.138 1.430 1.00 227.22 ? 253 MET A O 1 ATOM 2013 C CB . MET A 1 254 ? 62.306 141.739 0.883 1.00 227.22 ? 253 MET A CB 1 ATOM 2014 C CG . MET A 1 254 ? 61.183 142.673 0.566 1.00 227.22 ? 253 MET A CG 1 ATOM 2015 S SD . MET A 1 254 ? 61.688 144.447 0.563 1.00 227.22 ? 253 MET A SD 1 ATOM 2016 C CE . MET A 1 254 ? 59.893 144.992 0.802 1.00 227.22 ? 253 MET A CE 1 ATOM 2017 N N . VAL A 1 255 ? 60.666 139.249 -0.239 1.00 227.22 ? 254 VAL A N 1 ATOM 2018 C CA . VAL A 1 255 ? 59.510 138.669 -0.915 1.00 227.22 ? 254 VAL A CA 1 ATOM 2019 C C . VAL A 1 255 ? 58.764 137.730 0.013 1.00 227.22 ? 254 VAL A C 1 ATOM 2020 O O . VAL A 1 255 ? 57.559 137.876 0.211 1.00 227.22 ? 254 VAL A O 1 ATOM 2021 C CB . VAL A 1 255 ? 59.915 137.920 -2.210 1.00 227.22 ? 254 VAL A CB 1 ATOM 2022 C CG1 . VAL A 1 255 ? 58.912 136.810 -2.560 1.00 227.22 ? 254 VAL A CG1 1 ATOM 2023 C CG2 . VAL A 1 255 ? 60.071 138.906 -3.365 1.00 227.22 ? 254 VAL A CG2 1 ATOM 2024 N N . ILE A 1 256 ? 59.495 136.790 0.599 1.00 227.22 ? 255 ILE A N 1 ATOM 2025 C CA . ILE A 1 256 ? 58.870 135.708 1.345 1.00 227.22 ? 255 ILE A CA 1 ATOM 2026 C C . ILE A 1 256 ? 58.403 136.101 2.757 1.00 227.22 ? 255 ILE A C 1 ATOM 2027 O O . ILE A 1 256 ? 57.394 135.586 3.251 1.00 227.22 ? 255 ILE A O 1 ATOM 2028 C CB . ILE A 1 256 ? 59.707 134.397 1.250 1.00 227.22 ? 255 ILE A CB 1 ATOM 2029 C CG1 . ILE A 1 256 ? 59.200 133.569 0.058 1.00 227.22 ? 255 ILE A CG1 1 ATOM 2030 C CG2 . ILE A 1 256 ? 59.655 133.580 2.551 1.00 227.22 ? 255 ILE A CG2 1 ATOM 2031 C CD1 . ILE A 1 256 ? 60.279 132.859 -0.720 1.00 227.22 ? 255 ILE A CD1 1 ATOM 2032 N N . ILE A 1 257 ? 59.107 137.045 3.376 1.00 227.22 ? 256 ILE A N 1 ATOM 2033 C CA . ILE A 1 257 ? 58.594 137.708 4.569 1.00 227.22 ? 256 ILE A CA 1 ATOM 2034 C C . ILE A 1 257 ? 57.140 138.118 4.318 1.00 227.22 ? 256 ILE A C 1 ATOM 2035 O O . ILE A 1 257 ? 56.244 137.750 5.079 1.00 227.22 ? 256 ILE A O 1 ATOM 2036 C CB . ILE A 1 257 ? 59.463 138.937 4.940 1.00 227.22 ? 256 ILE A CB 1 ATOM 2037 C CG1 . ILE A 1 257 ? 60.829 138.491 5.480 1.00 227.22 ? 256 ILE A CG1 1 ATOM 2038 C CG2 . ILE A 1 257 ? 58.739 139.861 5.922 1.00 227.22 ? 256 ILE A CG2 1 ATOM 2039 C CD1 . ILE A 1 257 ? 60.788 137.686 6.772 1.00 227.22 ? 256 ILE A CD1 1 ATOM 2040 N N . MET A 1 258 ? 56.927 138.846 3.221 1.00 227.22 ? 257 MET A N 1 ATOM 2041 C CA . MET A 1 258 ? 55.605 139.294 2.786 1.00 227.22 ? 257 MET A CA 1 ATOM 2042 C C . MET A 1 258 ? 54.681 138.126 2.485 1.00 227.22 ? 257 MET A C 1 ATOM 2043 O O . MET A 1 258 ? 53.486 138.192 2.768 1.00 227.22 ? 257 MET A O 1 ATOM 2044 C CB . MET A 1 258 ? 55.718 140.153 1.526 1.00 227.22 ? 257 MET A CB 1 ATOM 2045 C CG . MET A 1 258 ? 56.680 141.316 1.617 1.00 227.22 ? 257 MET A CG 1 ATOM 2046 S SD . MET A 1 258 ? 57.184 141.903 -0.009 1.00 227.22 ? 257 MET A SD 1 ATOM 2047 C CE . MET A 1 258 ? 55.653 142.635 -0.593 1.00 227.22 ? 257 MET A CE 1 ATOM 2048 N N . VAL A 1 259 ? 55.238 137.074 1.889 1.00 227.22 ? 258 VAL A N 1 ATOM 2049 C CA . VAL A 1 259 ? 54.491 135.856 1.615 1.00 227.22 ? 258 VAL A CA 1 ATOM 2050 C C . VAL A 1 259 ? 53.893 135.364 2.923 1.00 227.22 ? 258 VAL A C 1 ATOM 2051 O O . VAL A 1 259 ? 52.687 135.113 2.999 1.00 227.22 ? 258 VAL A O 1 ATOM 2052 C CB . VAL A 1 259 ? 55.381 134.762 0.969 1.00 227.22 ? 258 VAL A CB 1 ATOM 2053 C CG1 . VAL A 1 259 ? 54.720 133.391 1.031 1.00 227.22 ? 258 VAL A CG1 1 ATOM 2054 C CG2 . VAL A 1 259 ? 55.707 135.124 -0.467 1.00 227.22 ? 258 VAL A CG2 1 ATOM 2055 N N . ILE A 1 260 ? 54.740 135.277 3.952 1.00 227.22 ? 259 ILE A N 1 ATOM 2056 C CA . ILE A 1 260 ? 54.360 134.782 5.282 1.00 227.22 ? 259 ILE A CA 1 ATOM 2057 C C . ILE A 1 260 ? 53.439 135.747 6.011 1.00 227.22 ? 259 ILE A C 1 ATOM 2058 O O . ILE A 1 260 ? 52.330 135.380 6.392 1.00 227.22 ? 259 ILE A O 1 ATOM 2059 C CB . ILE A 1 260 ? 55.597 134.511 6.162 1.00 227.22 ? 259 ILE A CB 1 ATOM 2060 C CG1 . ILE A 1 260 ? 56.486 133.448 5.511 1.00 227.22 ? 259 ILE A CG1 1 ATOM 2061 C CG2 . ILE A 1 260 ? 55.174 134.047 7.550 1.00 227.22 ? 259 ILE A CG2 1 ATOM 2062 C CD1 . ILE A 1 260 ? 57.947 133.511 5.934 1.00 227.22 ? 259 ILE A CD1 1 ATOM 2063 N N . ALA A 1 261 ? 53.913 136.973 6.205 1.00 227.22 ? 260 ALA A N 1 ATOM 2064 C CA . ALA A 1 261 ? 53.117 138.018 6.826 1.00 227.22 ? 260 ALA A CA 1 ATOM 2065 C C . ALA A 1 261 ? 51.711 138.070 6.227 1.00 227.22 ? 260 ALA A C 1 ATOM 2066 O O . ALA A 1 261 ? 50.726 138.062 6.965 1.00 227.22 ? 260 ALA A O 1 ATOM 2067 C CB . ALA A 1 261 ? 53.814 139.362 6.708 1.00 227.22 ? 260 ALA A CB 1 ATOM 2068 N N . PHE A 1 262 ? 51.620 138.099 4.896 1.00 227.22 ? 261 PHE A N 1 ATOM 2069 C CA . PHE A 1 262 ? 50.328 138.030 4.215 1.00 227.22 ? 261 PHE A CA 1 ATOM 2070 C C . PHE A 1 262 ? 49.493 136.898 4.796 1.00 227.22 ? 261 PHE A C 1 ATOM 2071 O O . PHE A 1 262 ? 48.363 137.114 5.237 1.00 227.22 ? 261 PHE A O 1 ATOM 2072 C CB . PHE A 1 262 ? 50.502 137.828 2.708 1.00 227.22 ? 261 PHE A CB 1 ATOM 2073 C CG . PHE A 1 262 ? 49.224 137.490 1.990 1.00 227.22 ? 261 PHE A CG 1 ATOM 2074 C CD1 . PHE A 1 262 ? 48.774 136.174 1.921 1.00 227.22 ? 261 PHE A CD1 1 ATOM 2075 C CD2 . PHE A 1 262 ? 48.471 138.487 1.379 1.00 227.22 ? 261 PHE A CD2 1 ATOM 2076 C CE1 . PHE A 1 262 ? 47.597 135.858 1.268 1.00 227.22 ? 261 PHE A CE1 1 ATOM 2077 C CE2 . PHE A 1 262 ? 47.290 138.180 0.715 1.00 227.22 ? 261 PHE A CE2 1 ATOM 2078 C CZ . PHE A 1 262 ? 46.852 136.863 0.663 1.00 227.22 ? 261 PHE A CZ 1 ATOM 2079 N N . LEU A 1 263 ? 50.072 135.698 4.802 1.00 227.22 ? 262 LEU A N 1 ATOM 2080 C CA . LEU A 1 263 ? 49.380 134.501 5.266 1.00 227.22 ? 262 LEU A CA 1 ATOM 2081 C C . LEU A 1 263 ? 49.046 134.567 6.756 1.00 227.22 ? 262 LEU A C 1 ATOM 2082 O O . LEU A 1 263 ? 48.002 134.067 7.171 1.00 227.22 ? 262 LEU A O 1 ATOM 2083 C CB . LEU A 1 263 ? 50.177 133.229 4.923 1.00 227.22 ? 262 LEU A CB 1 ATOM 2084 C CG . LEU A 1 263 ? 50.430 132.885 3.442 1.00 227.22 ? 262 LEU A CG 1 ATOM 2085 C CD1 . LEU A 1 263 ? 51.196 131.583 3.319 1.00 227.22 ? 262 LEU A CD1 1 ATOM 2086 C CD2 . LEU A 1 263 ? 49.148 132.811 2.626 1.00 227.22 ? 262 LEU A CD2 1 ATOM 2087 N N . ILE A 1 264 ? 49.919 135.206 7.540 1.00 227.22 ? 263 ILE A N 1 ATOM 2088 C CA . ILE A 1 264 ? 49.710 135.374 8.997 1.00 227.22 ? 263 ILE A CA 1 ATOM 2089 C C . ILE A 1 264 ? 48.492 136.229 9.332 1.00 227.22 ? 263 ILE A C 1 ATOM 2090 O O . ILE A 1 264 ? 47.788 135.960 10.308 1.00 227.22 ? 263 ILE A O 1 ATOM 2091 C CB . ILE A 1 264 ? 50.986 135.908 9.743 1.00 227.22 ? 263 ILE A CB 1 ATOM 2092 C CG1 . ILE A 1 264 ? 51.612 134.794 10.590 1.00 227.22 ? 263 ILE A CG1 1 ATOM 2093 C CG2 . ILE A 1 264 ? 50.670 137.099 10.653 1.00 227.22 ? 263 ILE A CG2 1 ATOM 2094 C CD1 . ILE A 1 264 ? 53.017 135.103 11.105 1.00 227.22 ? 263 ILE A CD1 1 ATOM 2095 N N . CYS A 1 265 ? 48.249 137.253 8.525 1.00 227.22 ? 264 CYS A N 1 ATOM 2096 C CA . CYS A 1 265 ? 47.137 138.141 8.779 1.00 227.22 ? 264 CYS A CA 1 ATOM 2097 C C . CYS A 1 265 ? 45.894 137.681 8.034 1.00 227.22 ? 264 CYS A C 1 ATOM 2098 O O . CYS A 1 265 ? 44.784 138.111 8.358 1.00 227.22 ? 264 CYS A O 1 ATOM 2099 C CB . CYS A 1 265 ? 47.504 139.568 8.389 1.00 227.22 ? 264 CYS A CB 1 ATOM 2100 S SG . CYS A 1 265 ? 46.340 140.804 8.976 1.00 227.22 ? 264 CYS A SG 1 ATOM 2101 N N . TRP A 1 266 ? 46.083 136.781 7.063 1.00 227.22 ? 265 TRP A N 1 ATOM 2102 C CA . TRP A 1 266 ? 45.019 136.422 6.112 1.00 227.22 ? 265 TRP A CA 1 ATOM 2103 C C . TRP A 1 266 ? 44.520 134.967 6.119 1.00 227.22 ? 265 TRP A C 1 ATOM 2104 O O . TRP A 1 266 ? 43.411 134.687 5.652 1.00 227.22 ? 265 TRP A O 1 ATOM 2105 C CB . TRP A 1 266 ? 45.393 136.887 4.701 1.00 227.22 ? 265 TRP A CB 1 ATOM 2106 C CG . TRP A 1 266 ? 45.277 138.369 4.566 1.00 227.22 ? 265 TRP A CG 1 ATOM 2107 C CD1 . TRP A 1 266 ? 46.292 139.278 4.571 1.00 227.22 ? 265 TRP A CD1 1 ATOM 2108 C CD2 . TRP A 1 266 ? 44.066 139.118 4.444 1.00 227.22 ? 265 TRP A CD2 1 ATOM 2109 N NE1 . TRP A 1 266 ? 45.788 140.548 4.446 1.00 227.22 ? 265 TRP A NE1 1 ATOM 2110 C CE2 . TRP A 1 266 ? 44.422 140.478 4.367 1.00 227.22 ? 265 TRP A CE2 1 ATOM 2111 C CE3 . TRP A 1 266 ? 42.712 138.770 4.386 1.00 227.22 ? 265 TRP A CE3 1 ATOM 2112 C CZ2 . TRP A 1 266 ? 43.476 141.491 4.229 1.00 227.22 ? 265 TRP A CZ2 1 ATOM 2113 C CZ3 . TRP A 1 266 ? 41.776 139.775 4.250 1.00 227.22 ? 265 TRP A CZ3 1 ATOM 2114 C CH2 . TRP A 1 266 ? 42.162 141.121 4.174 1.00 227.22 ? 265 TRP A CH2 1 ATOM 2115 N N . LEU A 1 267 ? 45.329 134.056 6.653 1.00 227.22 ? 266 LEU A N 1 ATOM 2116 C CA . LEU A 1 267 ? 44.874 132.687 6.906 1.00 227.22 ? 266 LEU A CA 1 ATOM 2117 C C . LEU A 1 267 ? 43.781 132.585 7.977 1.00 227.22 ? 266 LEU A C 1 ATOM 2118 O O . LEU A 1 267 ? 42.845 131.798 7.815 1.00 227.22 ? 266 LEU A O 1 ATOM 2119 C CB . LEU A 1 267 ? 46.043 131.766 7.268 1.00 227.22 ? 266 LEU A CB 1 ATOM 2120 C CG . LEU A 1 267 ? 46.355 130.587 6.348 1.00 227.22 ? 266 LEU A CG 1 ATOM 2121 C CD1 . LEU A 1 267 ? 46.733 131.047 4.948 1.00 227.22 ? 266 LEU A CD1 1 ATOM 2122 C CD2 . LEU A 1 267 ? 47.464 129.751 6.960 1.00 227.22 ? 266 LEU A CD2 1 ATOM 2123 N N . PRO A 1 268 ? 43.899 133.360 9.080 1.00 227.22 ? 267 PRO A N 1 ATOM 2124 C CA . PRO A 1 268 ? 42.832 133.318 10.067 1.00 227.22 ? 267 PRO A CA 1 ATOM 2125 C C . PRO A 1 268 ? 41.510 133.584 9.385 1.00 227.22 ? 267 PRO A C 1 ATOM 2126 O O . PRO A 1 268 ? 40.573 132.796 9.528 1.00 227.22 ? 267 PRO A O 1 ATOM 2127 C CB . PRO A 1 268 ? 43.182 134.473 11.005 1.00 227.22 ? 267 PRO A CB 1 ATOM 2128 C CG . PRO A 1 268 ? 44.637 134.576 10.921 1.00 227.22 ? 267 PRO A CG 1 ATOM 2129 C CD . PRO A 1 268 ? 44.968 134.288 9.493 1.00 227.22 ? 267 PRO A CD 1 ATOM 2130 N N . TYR A 1 269 ? 41.461 134.673 8.620 1.00 227.22 ? 268 TYR A N 1 ATOM 2131 C CA . TYR A 1 269 ? 40.281 135.018 7.848 1.00 227.22 ? 268 TYR A CA 1 ATOM 2132 C C . TYR A 1 269 ? 39.882 133.873 6.906 1.00 227.22 ? 268 TYR A C 1 ATOM 2133 O O . TYR A 1 269 ? 38.864 133.213 7.137 1.00 227.22 ? 268 TYR A O 1 ATOM 2134 C CB . TYR A 1 269 ? 40.481 136.331 7.079 1.00 227.22 ? 268 TYR A CB 1 ATOM 2135 C CG . TYR A 1 269 ? 39.205 136.826 6.446 1.00 227.22 ? 268 TYR A CG 1 ATOM 2136 C CD1 . TYR A 1 269 ? 38.243 137.491 7.206 1.00 227.22 ? 268 TYR A CD1 1 ATOM 2137 C CD2 . TYR A 1 269 ? 38.943 136.603 5.097 1.00 227.22 ? 268 TYR A CD2 1 ATOM 2138 C CE1 . TYR A 1 269 ? 37.063 137.931 6.637 1.00 227.22 ? 268 TYR A CE1 1 ATOM 2139 C CE2 . TYR A 1 269 ? 37.763 137.038 4.518 1.00 227.22 ? 268 TYR A CE2 1 ATOM 2140 C CZ . TYR A 1 269 ? 36.827 137.700 5.294 1.00 227.22 ? 268 TYR A CZ 1 ATOM 2141 O OH . TYR A 1 269 ? 35.655 138.134 4.723 1.00 227.22 ? 268 TYR A OH 1 ATOM 2142 N N . ALA A 1 270 ? 40.695 133.628 5.876 1.00 227.22 ? 269 ALA A N 1 ATOM 2143 C CA . ALA A 1 270 ? 40.453 132.553 4.904 1.00 227.22 ? 269 ALA A CA 1 ATOM 2144 C C . ALA A 1 270 ? 39.821 131.290 5.509 1.00 227.22 ? 269 ALA A C 1 ATOM 2145 O O . ALA A 1 270 ? 38.805 130.791 5.009 1.00 227.22 ? 269 ALA A O 1 ATOM 2146 C CB . ALA A 1 270 ? 41.747 132.203 4.188 1.00 227.22 ? 269 ALA A CB 1 ATOM 2147 N N . GLY A 1 271 ? 40.431 130.796 6.587 1.00 227.22 ? 270 GLY A N 1 ATOM 2148 C CA . GLY A 1 271 ? 39.979 129.596 7.287 1.00 227.22 ? 270 GLY A CA 1 ATOM 2149 C C . GLY A 1 271 ? 38.621 129.747 7.943 1.00 227.22 ? 270 GLY A C 1 ATOM 2150 O O . GLY A 1 271 ? 37.788 128.842 7.866 1.00 227.22 ? 270 GLY A O 1 ATOM 2151 N N . VAL A 1 272 ? 38.398 130.890 8.588 1.00 227.22 ? 271 VAL A N 1 ATOM 2152 C CA . VAL A 1 272 ? 37.121 131.171 9.243 1.00 227.22 ? 271 VAL A CA 1 ATOM 2153 C C . VAL A 1 272 ? 35.985 131.259 8.226 1.00 227.22 ? 271 VAL A C 1 ATOM 2154 O O . VAL A 1 272 ? 34.911 130.700 8.447 1.00 227.22 ? 271 VAL A O 1 ATOM 2155 C CB . VAL A 1 272 ? 37.192 132.446 10.113 1.00 227.22 ? 271 VAL A CB 1 ATOM 2156 C CG1 . VAL A 1 272 ? 35.802 132.926 10.491 1.00 227.22 ? 271 VAL A CG1 1 ATOM 2157 C CG2 . VAL A 1 272 ? 38.013 132.178 11.374 1.00 227.22 ? 271 VAL A CG2 1 ATOM 2158 N N . ALA A 1 273 ? 36.244 131.941 7.111 1.00 227.22 ? 272 ALA A N 1 ATOM 2159 C CA . ALA A 1 273 ? 35.297 132.042 5.992 1.00 227.22 ? 272 ALA A CA 1 ATOM 2160 C C . ALA A 1 273 ? 34.917 130.664 5.458 1.00 227.22 ? 272 ALA A C 1 ATOM 2161 O O . ALA A 1 273 ? 33.733 130.310 5.393 1.00 227.22 ? 272 ALA A O 1 ATOM 2162 C CB . ALA A 1 273 ? 35.876 132.908 4.872 1.00 227.22 ? 272 ALA A CB 1 ATOM 2163 N N . PHE A 1 274 ? 35.941 129.897 5.092 1.00 227.22 ? 273 PHE A N 1 ATOM 2164 C CA . PHE A 1 274 ? 35.802 128.522 4.625 1.00 227.22 ? 273 PHE A CA 1 ATOM 2165 C C . PHE A 1 274 ? 34.907 127.668 5.548 1.00 227.22 ? 273 PHE A C 1 ATOM 2166 O O . PHE A 1 274 ? 34.057 126.901 5.078 1.00 227.22 ? 273 PHE A O 1 ATOM 2167 C CB . PHE A 1 274 ? 37.204 127.924 4.510 1.00 227.22 ? 273 PHE A CB 1 ATOM 2168 C CG . PHE A 1 274 ? 37.237 126.544 3.947 1.00 227.22 ? 273 PHE A CG 1 ATOM 2169 C CD1 . PHE A 1 274 ? 37.465 126.343 2.597 1.00 227.22 ? 273 PHE A CD1 1 ATOM 2170 C CD2 . PHE A 1 274 ? 37.063 125.439 4.772 1.00 227.22 ? 273 PHE A CD2 1 ATOM 2171 C CE1 . PHE A 1 274 ? 37.505 125.057 2.075 1.00 227.22 ? 273 PHE A CE1 1 ATOM 2172 C CE2 . PHE A 1 274 ? 37.099 124.152 4.259 1.00 227.22 ? 273 PHE A CE2 1 ATOM 2173 C CZ . PHE A 1 274 ? 37.322 123.958 2.914 1.00 227.22 ? 273 PHE A CZ 1 ATOM 2174 N N . TYR A 1 275 ? 35.112 127.831 6.857 1.00 227.22 ? 274 TYR A N 1 ATOM 2175 C CA . TYR A 1 275 ? 34.389 127.114 7.915 1.00 227.22 ? 274 TYR A CA 1 ATOM 2176 C C . TYR A 1 275 ? 32.884 127.407 7.934 1.00 227.22 ? 274 TYR A C 1 ATOM 2177 O O . TYR A 1 275 ? 32.084 126.522 8.256 1.00 227.22 ? 274 TYR A O 1 ATOM 2178 C CB . TYR A 1 275 ? 35.019 127.462 9.271 1.00 227.22 ? 274 TYR A CB 1 ATOM 2179 C CG . TYR A 1 275 ? 34.408 126.792 10.490 1.00 227.22 ? 274 TYR A CG 1 ATOM 2180 C CD1 . TYR A 1 275 ? 34.885 125.564 10.951 1.00 227.22 ? 274 TYR A CD1 1 ATOM 2181 C CD2 . TYR A 1 275 ? 33.380 127.405 11.211 1.00 227.22 ? 274 TYR A CD2 1 ATOM 2182 C CE1 . TYR A 1 275 ? 34.336 124.950 12.093 1.00 227.22 ? 274 TYR A CE1 1 ATOM 2183 C CE2 . TYR A 1 275 ? 32.825 126.802 12.351 1.00 227.22 ? 274 TYR A CE2 1 ATOM 2184 C CZ . TYR A 1 275 ? 33.305 125.575 12.785 1.00 227.22 ? 274 TYR A CZ 1 ATOM 2185 O OH . TYR A 1 275 ? 32.759 124.981 13.903 1.00 227.22 ? 274 TYR A OH 1 ATOM 2186 N N . ILE A 1 276 ? 32.512 128.649 7.614 1.00 227.22 ? 275 ILE A N 1 ATOM 2187 C CA . ILE A 1 276 ? 31.105 129.037 7.519 1.00 227.22 ? 275 ILE A CA 1 ATOM 2188 C C . ILE A 1 276 ? 30.505 128.364 6.312 1.00 227.22 ? 275 ILE A C 1 ATOM 2189 O O . ILE A 1 276 ? 29.411 127.806 6.380 1.00 227.22 ? 275 ILE A O 1 ATOM 2190 C CB . ILE A 1 276 ? 30.919 130.545 7.291 1.00 227.22 ? 275 ILE A CB 1 ATOM 2191 C CG1 . ILE A 1 276 ? 31.728 131.349 8.298 1.00 227.22 ? 275 ILE A CG1 1 ATOM 2192 C CG2 . ILE A 1 276 ? 29.440 130.915 7.359 1.00 227.22 ? 275 ILE A CG2 1 ATOM 2193 C CD1 . ILE A 1 276 ? 32.234 132.662 7.747 1.00 227.22 ? 275 ILE A CD1 1 ATOM 2194 N N . PHE A 1 277 ? 31.244 128.431 5.208 1.00 227.22 ? 276 PHE A N 1 ATOM 2195 C CA . PHE A 1 277 ? 30.768 127.999 3.903 1.00 227.22 ? 276 PHE A CA 1 ATOM 2196 C C . PHE A 1 277 ? 30.303 126.539 3.902 1.00 227.22 ? 276 PHE A C 1 ATOM 2197 O O . PHE A 1 277 ? 29.330 126.192 3.224 1.00 227.22 ? 276 PHE A O 1 ATOM 2198 C CB . PHE A 1 277 ? 31.853 128.263 2.852 1.00 227.22 ? 276 PHE A CB 1 ATOM 2199 C CG . PHE A 1 277 ? 31.511 127.767 1.479 1.00 227.22 ? 276 PHE A CG 1 ATOM 2200 C CD1 . PHE A 1 277 ? 30.526 128.391 0.721 1.00 227.22 ? 276 PHE A CD1 1 ATOM 2201 C CD2 . PHE A 1 277 ? 32.185 126.678 0.938 1.00 227.22 ? 276 PHE A CD2 1 ATOM 2202 C CE1 . PHE A 1 277 ? 30.210 127.929 -0.556 1.00 227.22 ? 276 PHE A CE1 1 ATOM 2203 C CE2 . PHE A 1 277 ? 31.877 126.209 -0.330 1.00 227.22 ? 276 PHE A CE2 1 ATOM 2204 C CZ . PHE A 1 277 ? 30.888 126.837 -1.082 1.00 227.22 ? 276 PHE A CZ 1 ATOM 2205 N N . THR A 1 278 ? 30.986 125.701 4.680 1.00 227.22 ? 277 THR A N 1 ATOM 2206 C CA . THR A 1 278 ? 30.625 124.290 4.809 1.00 227.22 ? 277 THR A CA 1 ATOM 2207 C C . THR A 1 278 ? 29.403 124.111 5.708 1.00 227.22 ? 277 THR A C 1 ATOM 2208 O O . THR A 1 278 ? 28.540 123.267 5.441 1.00 227.22 ? 277 THR A O 1 ATOM 2209 C CB . THR A 1 278 ? 31.785 123.472 5.397 1.00 227.22 ? 277 THR A CB 1 ATOM 2210 O OG1 . THR A 1 278 ? 33.031 124.037 4.973 1.00 227.22 ? 277 THR A OG1 1 ATOM 2211 C CG2 . THR A 1 278 ? 31.696 122.009 4.962 1.00 227.22 ? 277 THR A CG2 1 ATOM 2212 N N . HIS A 1 279 ? 29.349 124.913 6.772 1.00 227.22 ? 278 HIS A N 1 ATOM 2213 C CA . HIS A 1 279 ? 28.321 124.812 7.816 1.00 227.22 ? 278 HIS A CA 1 ATOM 2214 C C . HIS A 1 279 ? 27.293 125.941 7.668 1.00 227.22 ? 278 HIS A C 1 ATOM 2215 O O . HIS A 1 279 ? 27.044 126.698 8.613 1.00 227.22 ? 278 HIS A O 1 ATOM 2216 C CB . HIS A 1 279 ? 28.974 124.855 9.213 1.00 227.22 ? 278 HIS A CB 1 ATOM 2217 C CG . HIS A 1 279 ? 30.197 123.997 9.344 1.00 227.22 ? 278 HIS A CG 1 ATOM 2218 N ND1 . HIS A 1 279 ? 31.476 124.497 9.225 1.00 227.22 ? 278 HIS A ND1 1 ATOM 2219 C CD2 . HIS A 1 279 ? 30.335 122.670 9.578 1.00 227.22 ? 278 HIS A CD2 1 ATOM 2220 C CE1 . HIS A 1 279 ? 32.349 123.517 9.378 1.00 227.22 ? 278 HIS A CE1 1 ATOM 2221 N NE2 . HIS A 1 279 ? 31.683 122.397 9.594 1.00 227.22 ? 278 HIS A NE2 1 ATOM 2222 N N . GLN A 1 280 ? 26.698 126.036 6.477 1.00 227.22 ? 279 GLN A N 1 ATOM 2223 C CA . GLN A 1 280 ? 25.853 127.173 6.087 1.00 227.22 ? 279 GLN A CA 1 ATOM 2224 C C . GLN A 1 280 ? 24.661 127.412 7.010 1.00 227.22 ? 279 GLN A C 1 ATOM 2225 O O . GLN A 1 280 ? 23.624 126.758 6.879 1.00 227.22 ? 279 GLN A O 1 ATOM 2226 C CB . GLN A 1 280 ? 25.359 127.014 4.642 1.00 227.22 ? 279 GLN A CB 1 ATOM 2227 C CG . GLN A 1 280 ? 26.380 127.369 3.564 1.00 227.22 ? 279 GLN A CG 1 ATOM 2228 C CD . GLN A 1 280 ? 25.764 128.136 2.404 1.00 227.22 ? 279 GLN A CD 1 ATOM 2229 O OE1 . GLN A 1 280 ? 24.601 127.930 2.044 1.00 227.22 ? 279 GLN A OE1 1 ATOM 2230 N NE2 . GLN A 1 280 ? 26.545 129.034 1.815 1.00 227.22 ? 279 GLN A NE2 1 ATOM 2231 N N . GLY A 1 281 ? 24.828 128.358 7.934 1.00 227.22 ? 280 GLY A N 1 ATOM 2232 C CA . GLY A 1 281 ? 23.779 128.747 8.888 1.00 227.22 ? 280 GLY A CA 1 ATOM 2233 C C . GLY A 1 281 ? 23.827 128.088 10.261 1.00 227.22 ? 280 GLY A C 1 ATOM 2234 O O . GLY A 1 281 ? 22.783 127.880 10.888 1.00 227.22 ? 280 GLY A O 1 ATOM 2235 N N . SER A 1 282 ? 25.034 127.771 10.730 1.00 227.22 ? 281 SER A N 1 ATOM 2236 C CA . SER A 1 282 ? 25.224 127.052 11.991 1.00 227.22 ? 281 SER A CA 1 ATOM 2237 C C . SER A 1 282 ? 25.226 127.957 13.237 1.00 227.22 ? 281 SER A C 1 ATOM 2238 O O . SER A 1 282 ? 24.980 129.163 13.139 1.00 227.22 ? 281 SER A O 1 ATOM 2239 C CB . SER A 1 282 ? 26.500 126.209 11.919 1.00 227.22 ? 281 SER A CB 1 ATOM 2240 O OG . SER A 1 282 ? 27.550 126.931 11.301 1.00 227.22 ? 281 SER A OG 1 ATOM 2241 N N . ASP A 1 283 ? 25.483 127.358 14.403 1.00 227.22 ? 282 ASP A N 1 ATOM 2242 C CA . ASP A 1 283 ? 25.570 128.084 15.676 1.00 227.22 ? 282 ASP A CA 1 ATOM 2243 C C . ASP A 1 283 ? 26.976 128.666 15.862 1.00 227.22 ? 282 ASP A C 1 ATOM 2244 O O . ASP A 1 283 ? 27.959 127.925 15.982 1.00 227.22 ? 282 ASP A O 1 ATOM 2245 C CB . ASP A 1 283 ? 25.203 127.161 16.857 1.00 227.22 ? 282 ASP A CB 1 ATOM 2246 C CG . ASP A 1 283 ? 24.967 127.923 18.173 1.00 227.22 ? 282 ASP A CG 1 ATOM 2247 O OD1 . ASP A 1 283 ? 25.898 127.978 19.012 1.00 227.22 ? 282 ASP A OD1 1 ATOM 2248 O OD2 . ASP A 1 283 ? 23.850 128.455 18.375 1.00 227.22 ? 282 ASP A OD2 1 ATOM 2249 N N . PHE A 1 284 ? 27.053 129.996 15.859 1.00 227.22 ? 283 PHE A N 1 ATOM 2250 C CA . PHE A 1 284 ? 28.286 130.747 16.127 1.00 227.22 ? 283 PHE A CA 1 ATOM 2251 C C . PHE A 1 284 ? 27.927 132.195 16.456 1.00 227.22 ? 283 PHE A C 1 ATOM 2252 O O . PHE A 1 284 ? 26.780 132.609 16.273 1.00 227.22 ? 283 PHE A O 1 ATOM 2253 C CB . PHE A 1 284 ? 29.290 130.660 14.956 1.00 227.22 ? 283 PHE A CB 1 ATOM 2254 C CG . PHE A 1 284 ? 28.717 131.050 13.604 1.00 227.22 ? 283 PHE A CG 1 ATOM 2255 C CD1 . PHE A 1 284 ? 28.871 132.346 13.112 1.00 227.22 ? 283 PHE A CD1 1 ATOM 2256 C CD2 . PHE A 1 284 ? 28.047 130.112 12.815 1.00 227.22 ? 283 PHE A CD2 1 ATOM 2257 C CE1 . PHE A 1 284 ? 28.351 132.708 11.871 1.00 227.22 ? 283 PHE A CE1 1 ATOM 2258 C CE2 . PHE A 1 284 ? 27.520 130.465 11.573 1.00 227.22 ? 283 PHE A CE2 1 ATOM 2259 C CZ . PHE A 1 284 ? 27.674 131.766 11.101 1.00 227.22 ? 283 PHE A CZ 1 ATOM 2260 N N . GLY A 1 285 ? 28.899 132.961 16.943 1.00 227.22 ? 284 GLY A N 1 ATOM 2261 C CA . GLY A 1 285 ? 28.628 134.321 17.411 1.00 227.22 ? 284 GLY A CA 1 ATOM 2262 C C . GLY A 1 285 ? 29.328 135.431 16.648 1.00 227.22 ? 284 GLY A C 1 ATOM 2263 O O . GLY A 1 285 ? 30.390 135.213 16.082 1.00 227.22 ? 284 GLY A O 1 ATOM 2264 N N . PRO A 1 286 ? 28.747 136.644 16.660 1.00 227.22 ? 285 PRO A N 1 ATOM 2265 C CA . PRO A 1 286 ? 29.272 137.822 15.962 1.00 227.22 ? 285 PRO A CA 1 ATOM 2266 C C . PRO A 1 286 ? 30.769 138.024 16.158 1.00 227.22 ? 285 PRO A C 1 ATOM 2267 O O . PRO A 1 286 ? 31.424 138.633 15.317 1.00 227.22 ? 285 PRO A O 1 ATOM 2268 C CB . PRO A 1 286 ? 28.513 138.990 16.616 1.00 227.22 ? 285 PRO A CB 1 ATOM 2269 C CG . PRO A 1 286 ? 27.739 138.394 17.771 1.00 227.22 ? 285 PRO A CG 1 ATOM 2270 C CD . PRO A 1 286 ? 27.514 136.970 17.393 1.00 227.22 ? 285 PRO A CD 1 ATOM 2271 N N . ILE A 1 287 ? 31.289 137.510 17.266 1.00 227.22 ? 286 ILE A N 1 ATOM 2272 C CA . ILE A 1 287 ? 32.695 137.660 17.639 1.00 227.22 ? 286 ILE A CA 1 ATOM 2273 C C . ILE A 1 287 ? 33.594 136.788 16.739 1.00 227.22 ? 286 ILE A C 1 ATOM 2274 O O . ILE A 1 287 ? 34.785 137.061 16.571 1.00 227.22 ? 286 ILE A O 1 ATOM 2275 C CB . ILE A 1 287 ? 32.914 137.322 19.159 1.00 227.22 ? 286 ILE A CB 1 ATOM 2276 C CG1 . ILE A 1 287 ? 31.619 137.525 19.971 1.00 227.22 ? 286 ILE A CG1 1 ATOM 2277 C CG2 . ILE A 1 287 ? 34.045 138.170 19.741 1.00 227.22 ? 286 ILE A CG2 1 ATOM 2278 C CD1 . ILE A 1 287 ? 31.360 136.463 21.040 1.00 227.22 ? 286 ILE A CD1 1 ATOM 2279 N N . PHE A 1 288 ? 32.986 135.763 16.145 1.00 227.22 ? 287 PHE A N 1 ATOM 2280 C CA . PHE A 1 288 ? 33.661 134.738 15.336 1.00 227.22 ? 287 PHE A CA 1 ATOM 2281 C C . PHE A 1 288 ? 34.432 135.284 14.124 1.00 227.22 ? 287 PHE A C 1 ATOM 2282 O O . PHE A 1 288 ? 35.626 135.013 13.975 1.00 227.22 ? 287 PHE A O 1 ATOM 2283 C CB . PHE A 1 288 ? 32.610 133.681 14.924 1.00 227.22 ? 287 PHE A CB 1 ATOM 2284 C CG . PHE A 1 288 ? 33.120 132.563 14.030 1.00 227.22 ? 287 PHE A CG 1 ATOM 2285 C CD1 . PHE A 1 288 ? 34.361 131.961 14.247 1.00 227.22 ? 287 PHE A CD1 1 ATOM 2286 C CD2 . PHE A 1 288 ? 32.306 132.069 13.005 1.00 227.22 ? 287 PHE A CD2 1 ATOM 2287 C CE1 . PHE A 1 288 ? 34.795 130.923 13.428 1.00 227.22 ? 287 PHE A CE1 1 ATOM 2288 C CE2 . PHE A 1 288 ? 32.727 131.030 12.189 1.00 227.22 ? 287 PHE A CE2 1 ATOM 2289 C CZ . PHE A 1 288 ? 33.974 130.456 12.399 1.00 227.22 ? 287 PHE A CZ 1 ATOM 2290 N N . MET A 1 289 ? 33.749 136.047 13.273 1.00 227.22 ? 288 MET A N 1 ATOM 2291 C CA . MET A 1 289 ? 34.333 136.545 12.027 1.00 227.22 ? 288 MET A CA 1 ATOM 2292 C C . MET A 1 289 ? 34.972 137.911 12.231 1.00 227.22 ? 288 MET A C 1 ATOM 2293 O O . MET A 1 289 ? 35.975 138.236 11.593 1.00 227.22 ? 288 MET A O 1 ATOM 2294 C CB . MET A 1 289 ? 33.263 136.613 10.930 1.00 227.22 ? 288 MET A CB 1 ATOM 2295 C CG . MET A 1 289 ? 33.785 136.855 9.506 1.00 227.22 ? 288 MET A CG 1 ATOM 2296 S SD . MET A 1 289 ? 34.725 135.491 8.783 1.00 227.22 ? 288 MET A SD 1 ATOM 2297 C CE . MET A 1 289 ? 34.354 135.709 7.051 1.00 227.22 ? 288 MET A CE 1 ATOM 2298 N N . THR A 1 290 ? 34.386 138.691 13.135 1.00 227.22 ? 289 THR A N 1 ATOM 2299 C CA . THR A 1 290 ? 34.796 140.071 13.391 1.00 227.22 ? 289 THR A CA 1 ATOM 2300 C C . THR A 1 290 ? 36.281 140.198 13.752 1.00 227.22 ? 289 THR A C 1 ATOM 2301 O O . THR A 1 290 ? 36.937 141.163 13.352 1.00 227.22 ? 289 THR A O 1 ATOM 2302 C CB . THR A 1 290 ? 33.900 140.729 14.482 1.00 227.22 ? 289 THR A CB 1 ATOM 2303 O OG1 . THR A 1 290 ? 32.532 140.701 14.061 1.00 227.22 ? 289 THR A OG1 1 ATOM 2304 C CG2 . THR A 1 290 ? 34.295 142.176 14.730 1.00 227.22 ? 289 THR A CG2 1 ATOM 2305 N N . ILE A 1 291 ? 36.808 139.222 14.488 1.00 227.22 ? 290 ILE A N 1 ATOM 2306 C CA . ILE A 1 291 ? 38.215 139.251 14.898 1.00 227.22 ? 290 ILE A CA 1 ATOM 2307 C C . ILE A 1 291 ? 39.187 139.074 13.716 1.00 227.22 ? 290 ILE A C 1 ATOM 2308 O O . ILE A 1 291 ? 39.994 139.970 13.459 1.00 227.22 ? 290 ILE A O 1 ATOM 2309 C CB . ILE A 1 291 ? 38.517 138.240 16.042 1.00 227.22 ? 290 ILE A CB 1 ATOM 2310 C CG1 . ILE A 1 291 ? 37.607 138.489 17.256 1.00 227.22 ? 290 ILE A CG1 1 ATOM 2311 C CG2 . ILE A 1 291 ? 40.003 138.258 16.419 1.00 227.22 ? 290 ILE A CG2 1 ATOM 2312 C CD1 . ILE A 1 291 ? 37.725 139.876 17.893 1.00 227.22 ? 290 ILE A CD1 1 ATOM 2313 N N . PRO A 1 292 ? 39.112 137.933 12.991 1.00 227.22 ? 291 PRO A N 1 ATOM 2314 C CA . PRO A 1 292 ? 39.982 137.732 11.824 1.00 227.22 ? 291 PRO A CA 1 ATOM 2315 C C . PRO A 1 292 ? 39.678 138.702 10.691 1.00 227.22 ? 291 PRO A C 1 ATOM 2316 O O . PRO A 1 292 ? 40.448 138.797 9.736 1.00 227.22 ? 291 PRO A O 1 ATOM 2317 C CB . PRO A 1 292 ? 39.658 136.299 11.385 1.00 227.22 ? 291 PRO A CB 1 ATOM 2318 C CG . PRO A 1 292 ? 39.035 135.660 12.584 1.00 227.22 ? 291 PRO A CG 1 ATOM 2319 C CD . PRO A 1 292 ? 38.250 136.759 13.210 1.00 227.22 ? 291 PRO A CD 1 ATOM 2320 N N . ALA A 1 293 ? 38.556 139.403 10.805 1.00 227.22 ? 292 ALA A N 1 ATOM 2321 C CA . ALA A 1 293 ? 38.228 140.484 9.894 1.00 227.22 ? 292 ALA A CA 1 ATOM 2322 C C . ALA A 1 293 ? 39.098 141.712 10.175 1.00 227.22 ? 292 ALA A C 1 ATOM 2323 O O . ALA A 1 293 ? 40.080 141.948 9.466 1.00 227.22 ? 292 ALA A O 1 ATOM 2324 C CB . ALA A 1 293 ? 36.745 140.835 9.984 1.00 227.22 ? 292 ALA A CB 1 ATOM 2325 N N . PHE A 1 294 ? 38.744 142.469 11.218 1.00 227.22 ? 293 PHE A N 1 ATOM 2326 C CA . PHE A 1 294 ? 39.395 143.747 11.547 1.00 227.22 ? 293 PHE A CA 1 ATOM 2327 C C . PHE A 1 294 ? 40.902 143.639 11.713 1.00 227.22 ? 293 PHE A C 1 ATOM 2328 O O . PHE A 1 294 ? 41.635 144.552 11.342 1.00 227.22 ? 293 PHE A O 1 ATOM 2329 C CB . PHE A 1 294 ? 38.782 144.358 12.803 1.00 227.22 ? 293 PHE A CB 1 ATOM 2330 C CG . PHE A 1 294 ? 37.464 145.033 12.570 1.00 227.22 ? 293 PHE A CG 1 ATOM 2331 C CD1 . PHE A 1 294 ? 36.272 144.379 12.859 1.00 227.22 ? 293 PHE A CD1 1 ATOM 2332 C CD2 . PHE A 1 294 ? 37.412 146.330 12.073 1.00 227.22 ? 293 PHE A CD2 1 ATOM 2333 C CE1 . PHE A 1 294 ? 35.042 145.007 12.654 1.00 227.22 ? 293 PHE A CE1 1 ATOM 2334 C CE2 . PHE A 1 294 ? 36.190 146.967 11.863 1.00 227.22 ? 293 PHE A CE2 1 ATOM 2335 C CZ . PHE A 1 294 ? 35.003 146.304 12.156 1.00 227.22 ? 293 PHE A CZ 1 ATOM 2336 N N . PHE A 1 295 ? 41.350 142.525 12.280 1.00 227.22 ? 294 PHE A N 1 ATOM 2337 C CA . PHE A 1 295 ? 42.764 142.193 12.338 1.00 227.22 ? 294 PHE A CA 1 ATOM 2338 C C . PHE A 1 295 ? 43.353 142.138 10.924 1.00 227.22 ? 294 PHE A C 1 ATOM 2339 O O . PHE A 1 295 ? 44.305 142.860 10.618 1.00 227.22 ? 294 PHE A O 1 ATOM 2340 C CB . PHE A 1 295 ? 42.945 140.863 13.078 1.00 227.22 ? 294 PHE A CB 1 ATOM 2341 C CG . PHE A 1 295 ? 44.357 140.351 13.104 1.00 227.22 ? 294 PHE A CG 1 ATOM 2342 C CD1 . PHE A 1 295 ? 45.390 141.132 13.613 1.00 227.22 ? 294 PHE A CD1 1 ATOM 2343 C CD2 . PHE A 1 295 ? 44.647 139.067 12.650 1.00 227.22 ? 294 PHE A CD2 1 ATOM 2344 C CE1 . PHE A 1 295 ? 46.696 140.648 13.645 1.00 227.22 ? 294 PHE A CE1 1 ATOM 2345 C CE2 . PHE A 1 295 ? 45.947 138.572 12.679 1.00 227.22 ? 294 PHE A CE2 1 ATOM 2346 C CZ . PHE A 1 295 ? 46.974 139.363 13.178 1.00 227.22 ? 294 PHE A CZ 1 ATOM 2347 N N . ALA A 1 296 ? 42.756 141.316 10.061 1.00 227.22 ? 295 ALA A N 1 ATOM 2348 C CA . ALA A 1 296 ? 43.240 141.121 8.696 1.00 227.22 ? 295 ALA A CA 1 ATOM 2349 C C . ALA A 1 296 ? 43.450 142.421 7.918 1.00 227.22 ? 295 ALA A C 1 ATOM 2350 O O . ALA A 1 296 ? 44.280 142.480 7.016 1.00 227.22 ? 295 ALA A O 1 ATOM 2351 C CB . ALA A 1 296 ? 42.318 140.200 7.943 1.00 227.22 ? 295 ALA A CB 1 ATOM 2352 N N . LYS A 1 297 ? 42.716 143.466 8.280 1.00 227.22 ? 296 LYS A N 1 ATOM 2353 C CA . LYS A 1 297 ? 42.795 144.739 7.564 1.00 227.22 ? 296 LYS A CA 1 ATOM 2354 C C . LYS A 1 297 ? 44.070 145.542 7.859 1.00 227.22 ? 296 LYS A C 1 ATOM 2355 O O . LYS A 1 297 ? 44.153 146.722 7.508 1.00 227.22 ? 296 LYS A O 1 ATOM 2356 C CB . LYS A 1 297 ? 41.550 145.592 7.828 1.00 227.22 ? 296 LYS A CB 1 ATOM 2357 C CG . LYS A 1 297 ? 40.230 144.997 7.344 1.00 227.22 ? 296 LYS A CG 1 ATOM 2358 C CD . LYS A 1 297 ? 39.103 145.976 7.652 1.00 227.22 ? 296 LYS A CD 1 ATOM 2359 C CE . LYS A 1 297 ? 37.811 145.279 8.052 1.00 227.22 ? 296 LYS A CE 1 ATOM 2360 N NZ . LYS A 1 297 ? 36.763 145.387 7.007 1.00 227.22 ? 296 LYS A NZ 1 ATOM 2361 N N . THR A 1 298 ? 45.060 144.910 8.488 1.00 227.22 ? 297 THR A N 1 ATOM 2362 C CA . THR A 1 298 ? 46.384 145.525 8.637 1.00 227.22 ? 297 THR A CA 1 ATOM 2363 C C . THR A 1 298 ? 47.160 145.443 7.324 1.00 227.22 ? 297 THR A C 1 ATOM 2364 O O . THR A 1 298 ? 48.246 146.021 7.191 1.00 227.22 ? 297 THR A O 1 ATOM 2365 C CB . THR A 1 298 ? 47.213 144.856 9.734 1.00 227.22 ? 297 THR A CB 1 ATOM 2366 O OG1 . THR A 1 298 ? 47.354 143.463 9.440 1.00 227.22 ? 297 THR A OG1 1 ATOM 2367 C CG2 . THR A 1 298 ? 46.553 145.042 11.091 1.00 227.22 ? 297 THR A CG2 1 ATOM 2368 N N . SER A 1 299 ? 46.575 144.719 6.365 1.00 227.22 ? 298 SER A N 1 ATOM 2369 C CA . SER A 1 299 ? 47.115 144.520 5.016 1.00 227.22 ? 298 SER A CA 1 ATOM 2370 C C . SER A 1 299 ? 47.314 145.820 4.255 1.00 227.22 ? 298 SER A C 1 ATOM 2371 O O . SER A 1 299 ? 48.063 145.869 3.273 1.00 227.22 ? 298 SER A O 1 ATOM 2372 C CB . SER A 1 299 ? 46.204 143.596 4.223 1.00 227.22 ? 298 SER A CB 1 ATOM 2373 O OG . SER A 1 299 ? 44.860 144.016 4.333 1.00 227.22 ? 298 SER A OG 1 ATOM 2374 N N . ALA A 1 300 ? 46.636 146.865 4.720 1.00 227.22 ? 299 ALA A N 1 ATOM 2375 C CA . ALA A 1 300 ? 46.810 148.213 4.200 1.00 227.22 ? 299 ALA A CA 1 ATOM 2376 C C . ALA A 1 300 ? 47.977 148.951 4.863 1.00 227.22 ? 299 ALA A C 1 ATOM 2377 O O . ALA A 1 300 ? 48.216 150.123 4.578 1.00 227.22 ? 299 ALA A O 1 ATOM 2378 C CB . ALA A 1 300 ? 45.521 149.006 4.354 1.00 227.22 ? 299 ALA A CB 1 ATOM 2379 N N . VAL A 1 301 ? 48.710 148.269 5.737 1.00 227.22 ? 300 VAL A N 1 ATOM 2380 C CA . VAL A 1 301 ? 49.761 148.930 6.491 1.00 227.22 ? 300 VAL A CA 1 ATOM 2381 C C . VAL A 1 301 ? 51.057 148.134 6.545 1.00 227.22 ? 300 VAL A C 1 ATOM 2382 O O . VAL A 1 301 ? 52.116 148.672 6.243 1.00 227.22 ? 300 VAL A O 1 ATOM 2383 C CB . VAL A 1 301 ? 49.288 149.267 7.915 1.00 227.22 ? 300 VAL A CB 1 ATOM 2384 C CG1 . VAL A 1 301 ? 50.414 149.874 8.744 1.00 227.22 ? 300 VAL A CG1 1 ATOM 2385 C CG2 . VAL A 1 301 ? 48.107 150.213 7.867 1.00 227.22 ? 300 VAL A CG2 1 ATOM 2386 N N . TYR A 1 302 ? 50.973 146.860 6.914 1.00 227.22 ? 301 TYR A N 1 ATOM 2387 C CA . TYR A 1 302 ? 52.174 146.062 7.181 1.00 227.22 ? 301 TYR A CA 1 ATOM 2388 C C . TYR A 1 302 ? 53.158 145.967 6.012 1.00 227.22 ? 301 TYR A C 1 ATOM 2389 O O . TYR A 1 302 ? 54.362 145.882 6.239 1.00 227.22 ? 301 TYR A O 1 ATOM 2390 C CB . TYR A 1 302 ? 51.808 144.661 7.688 1.00 227.22 ? 301 TYR A CB 1 ATOM 2391 C CG . TYR A 1 302 ? 51.376 143.696 6.613 1.00 227.22 ? 301 TYR A CG 1 ATOM 2392 C CD1 . TYR A 1 302 ? 52.286 142.819 6.028 1.00 227.22 ? 301 TYR A CD1 1 ATOM 2393 C CD2 . TYR A 1 302 ? 50.059 143.659 6.180 1.00 227.22 ? 301 TYR A CD2 1 ATOM 2394 C CE1 . TYR A 1 302 ? 51.889 141.930 5.031 1.00 227.22 ? 301 TYR A CE1 1 ATOM 2395 C CE2 . TYR A 1 302 ? 49.650 142.775 5.186 1.00 227.22 ? 301 TYR A CE2 1 ATOM 2396 C CZ . TYR A 1 302 ? 50.565 141.915 4.617 1.00 227.22 ? 301 TYR A CZ 1 ATOM 2397 O OH . TYR A 1 302 ? 50.146 141.045 3.637 1.00 227.22 ? 301 TYR A OH 1 ATOM 2398 N N . ASN A 1 303 ? 52.637 145.985 4.779 1.00 227.22 ? 302 ASN A N 1 ATOM 2399 C CA . ASN A 1 303 ? 53.431 145.825 3.543 1.00 227.22 ? 302 ASN A CA 1 ATOM 2400 C C . ASN A 1 303 ? 54.539 146.858 3.348 1.00 227.22 ? 302 ASN A C 1 ATOM 2401 O O . ASN A 1 303 ? 55.711 146.492 3.233 1.00 227.22 ? 302 ASN A O 1 ATOM 2402 C CB . ASN A 1 303 ? 52.518 145.798 2.321 1.00 227.22 ? 302 ASN A CB 1 ATOM 2403 C CG . ASN A 1 303 ? 51.684 144.558 2.262 1.00 227.22 ? 302 ASN A CG 1 ATOM 2404 O OD1 . ASN A 1 303 ? 52.211 143.448 2.252 1.00 227.22 ? 302 ASN A OD1 1 ATOM 2405 N ND2 . ASN A 1 303 ? 50.368 144.731 2.225 1.00 227.22 ? 302 ASN A ND2 1 ATOM 2406 N N . PRO A 1 304 ? 54.171 148.148 3.276 1.00 227.22 ? 303 PRO A N 1 ATOM 2407 C CA . PRO A 1 304 ? 55.159 149.211 3.425 1.00 227.22 ? 303 PRO A CA 1 ATOM 2408 C C . PRO A 1 304 ? 56.125 149.002 4.600 1.00 227.22 ? 303 PRO A C 1 ATOM 2409 O O . PRO A 1 304 ? 57.326 149.163 4.417 1.00 227.22 ? 303 PRO A O 1 ATOM 2410 C CB . PRO A 1 304 ? 54.294 150.445 3.660 1.00 227.22 ? 303 PRO A CB 1 ATOM 2411 C CG . PRO A 1 304 ? 53.063 150.161 2.892 1.00 227.22 ? 303 PRO A CG 1 ATOM 2412 C CD . PRO A 1 304 ? 52.829 148.690 2.988 1.00 227.22 ? 303 PRO A CD 1 ATOM 2413 N N . VAL A 1 305 ? 55.608 148.631 5.775 1.00 227.22 ? 304 VAL A N 1 ATOM 2414 C CA . VAL A 1 305 ? 56.424 148.468 6.999 1.00 227.22 ? 304 VAL A CA 1 ATOM 2415 C C . VAL A 1 305 ? 57.551 147.436 6.860 1.00 227.22 ? 304 VAL A C 1 ATOM 2416 O O . VAL A 1 305 ? 58.644 147.627 7.410 1.00 227.22 ? 304 VAL A O 1 ATOM 2417 C CB . VAL A 1 305 ? 55.561 148.113 8.234 1.00 227.22 ? 304 VAL A CB 1 ATOM 2418 C CG1 . VAL A 1 305 ? 56.328 148.394 9.524 1.00 227.22 ? 304 VAL A CG1 1 ATOM 2419 C CG2 . VAL A 1 305 ? 54.275 148.902 8.225 1.00 227.22 ? 304 VAL A CG2 1 ATOM 2420 N N . ILE A 1 306 ? 57.271 146.348 6.138 1.00 227.22 ? 305 ILE A N 1 ATOM 2421 C CA . ILE A 1 306 ? 58.297 145.376 5.745 1.00 227.22 ? 305 ILE A CA 1 ATOM 2422 C C . ILE A 1 306 ? 59.316 146.070 4.844 1.00 227.22 ? 305 ILE A C 1 ATOM 2423 O O . ILE A 1 306 ? 60.527 145.957 5.052 1.00 227.22 ? 305 ILE A O 1 ATOM 2424 C CB . ILE A 1 306 ? 57.710 144.163 4.974 1.00 227.22 ? 305 ILE A CB 1 ATOM 2425 C CG1 . ILE A 1 306 ? 56.642 143.447 5.796 1.00 227.22 ? 305 ILE A CG1 1 ATOM 2426 C CG2 . ILE A 1 306 ? 58.808 143.176 4.620 1.00 227.22 ? 305 ILE A CG2 1 ATOM 2427 C CD1 . ILE A 1 306 ? 55.865 142.407 5.010 1.00 227.22 ? 305 ILE A CD1 1 ATOM 2428 N N . TYR A 1 307 ? 58.809 146.797 3.853 1.00 227.22 ? 306 TYR A N 1 ATOM 2429 C CA . TYR A 1 307 ? 59.641 147.507 2.890 1.00 227.22 ? 306 TYR A CA 1 ATOM 2430 C C . TYR A 1 307 ? 60.516 148.573 3.544 1.00 227.22 ? 306 TYR A C 1 ATOM 2431 O O . TYR A 1 307 ? 61.640 148.824 3.100 1.00 227.22 ? 306 TYR A O 1 ATOM 2432 C CB . TYR A 1 307 ? 58.744 148.116 1.814 1.00 227.22 ? 306 TYR A CB 1 ATOM 2433 C CG . TYR A 1 307 ? 59.467 148.741 0.640 1.00 227.22 ? 306 TYR A CG 1 ATOM 2434 C CD1 . TYR A 1 307 ? 60.736 148.301 0.247 1.00 227.22 ? 306 TYR A CD1 1 ATOM 2435 C CD2 . TYR A 1 307 ? 58.861 149.751 -0.105 1.00 227.22 ? 306 TYR A CD2 1 ATOM 2436 C CE1 . TYR A 1 307 ? 61.387 148.870 -0.836 1.00 227.22 ? 306 TYR A CE1 1 ATOM 2437 C CE2 . TYR A 1 307 ? 59.504 150.327 -1.188 1.00 227.22 ? 306 TYR A CE2 1 ATOM 2438 C CZ . TYR A 1 307 ? 60.765 149.883 -1.549 1.00 227.22 ? 306 TYR A CZ 1 ATOM 2439 O OH . TYR A 1 307 ? 61.405 150.456 -2.623 1.00 227.22 ? 306 TYR A OH 1 ATOM 2440 N N . ILE A 1 308 ? 59.980 149.189 4.596 1.00 227.22 ? 307 ILE A N 1 ATOM 2441 C CA . ILE A 1 308 ? 60.695 150.164 5.417 1.00 227.22 ? 307 ILE A CA 1 ATOM 2442 C C . ILE A 1 308 ? 61.796 149.474 6.216 1.00 227.22 ? 307 ILE A C 1 ATOM 2443 O O . ILE A 1 308 ? 62.947 149.917 6.211 1.00 227.22 ? 307 ILE A O 1 ATOM 2444 C CB . ILE A 1 308 ? 59.734 150.902 6.383 1.00 227.22 ? 307 ILE A CB 1 ATOM 2445 C CG1 . ILE A 1 308 ? 58.780 151.807 5.598 1.00 227.22 ? 307 ILE A CG1 1 ATOM 2446 C CG2 . ILE A 1 308 ? 60.511 151.726 7.410 1.00 227.22 ? 307 ILE A CG2 1 ATOM 2447 C CD1 . ILE A 1 308 ? 57.423 152.030 6.272 1.00 227.22 ? 307 ILE A CD1 1 ATOM 2448 N N . MET A 1 309 ? 61.437 148.393 6.900 1.00 227.22 ? 308 MET A N 1 ATOM 2449 C CA . MET A 1 309 ? 62.403 147.648 7.692 1.00 227.22 ? 308 MET A CA 1 ATOM 2450 C C . MET A 1 309 ? 63.495 146.999 6.832 1.00 227.22 ? 308 MET A C 1 ATOM 2451 O O . MET A 1 309 ? 64.684 147.297 6.992 1.00 227.22 ? 308 MET A O 1 ATOM 2452 C CB . MET A 1 309 ? 61.698 146.597 8.566 1.00 227.22 ? 308 MET A CB 1 ATOM 2453 C CG . MET A 1 309 ? 61.447 147.020 10.018 1.00 227.22 ? 308 MET A CG 1 ATOM 2454 S SD . MET A 1 309 ? 62.943 147.233 11.027 1.00 227.22 ? 308 MET A SD 1 ATOM 2455 C CE . MET A 1 309 ? 63.711 145.607 10.926 1.00 227.22 ? 308 MET A CE 1 ATOM 2456 N N . MET A 1 310 ? 63.080 146.152 5.894 1.00 227.22 ? 309 MET A N 1 ATOM 2457 C CA . MET A 1 310 ? 63.990 145.188 5.278 1.00 227.22 ? 309 MET A CA 1 ATOM 2458 C C . MET A 1 310 ? 64.896 145.679 4.141 1.00 227.22 ? 309 MET A C 1 ATOM 2459 O O . MET A 1 310 ? 65.949 145.079 3.909 1.00 227.22 ? 309 MET A O 1 ATOM 2460 C CB . MET A 1 310 ? 63.227 143.939 4.839 1.00 227.22 ? 309 MET A CB 1 ATOM 2461 C CG . MET A 1 310 ? 62.743 143.092 5.988 1.00 227.22 ? 309 MET A CG 1 ATOM 2462 S SD . MET A 1 310 ? 62.485 141.382 5.511 1.00 227.22 ? 309 MET A SD 1 ATOM 2463 C CE . MET A 1 310 ? 64.180 140.818 5.309 1.00 227.22 ? 309 MET A CE 1 ATOM 2464 N N . ASN A 1 311 ? 64.507 146.741 3.432 1.00 227.22 ? 310 ASN A N 1 ATOM 2465 C CA . ASN A 1 311 ? 65.309 147.207 2.289 1.00 227.22 ? 310 ASN A CA 1 ATOM 2466 C C . ASN A 1 311 ? 66.153 148.449 2.567 1.00 227.22 ? 310 ASN A C 1 ATOM 2467 O O . ASN A 1 311 ? 65.621 149.549 2.723 1.00 227.22 ? 310 ASN A O 1 ATOM 2468 C CB . ASN A 1 311 ? 64.442 147.402 1.042 1.00 227.22 ? 310 ASN A CB 1 ATOM 2469 C CG . ASN A 1 311 ? 65.239 147.266 -0.240 1.00 227.22 ? 310 ASN A CG 1 ATOM 2470 O OD1 . ASN A 1 311 ? 65.831 148.232 -0.734 1.00 227.22 ? 310 ASN A OD1 1 ATOM 2471 N ND2 . ASN A 1 311 ? 65.262 146.053 -0.785 1.00 227.22 ? 310 ASN A ND2 1 ATOM 2472 N N . LYS A 1 312 ? 67.471 148.260 2.606 1.00 227.22 ? 311 LYS A N 1 ATOM 2473 C CA . LYS A 1 312 ? 68.410 149.323 2.979 1.00 227.22 ? 311 LYS A CA 1 ATOM 2474 C C . LYS A 1 312 ? 68.316 150.563 2.074 1.00 227.22 ? 311 LYS A C 1 ATOM 2475 O O . LYS A 1 312 ? 68.346 151.699 2.558 1.00 227.22 ? 311 LYS A O 1 ATOM 2476 C CB . LYS A 1 312 ? 69.853 148.787 3.018 1.00 227.22 ? 311 LYS A CB 1 ATOM 2477 C CG . LYS A 1 312 ? 70.808 149.616 3.888 1.00 227.22 ? 311 LYS A CG 1 ATOM 2478 C CD . LYS A 1 312 ? 72.271 149.218 3.697 1.00 227.22 ? 311 LYS A CD 1 ATOM 2479 C CE . LYS A 1 312 ? 73.170 149.829 4.774 1.00 227.22 ? 311 LYS A CE 1 ATOM 2480 N NZ . LYS A 1 312 ? 73.080 151.318 4.863 1.00 227.22 ? 311 LYS A NZ 1 ATOM 2481 N N . GLN A 1 313 ? 68.199 150.331 0.769 1.00 227.22 ? 312 GLN A N 1 ATOM 2482 C CA . GLN A 1 313 ? 68.145 151.399 -0.233 1.00 227.22 ? 312 GLN A CA 1 ATOM 2483 C C . GLN A 1 313 ? 66.983 152.370 0.024 1.00 227.22 ? 312 GLN A C 1 ATOM 2484 O O . GLN A 1 313 ? 67.195 153.570 0.222 1.00 227.22 ? 312 GLN A O 1 ATOM 2485 C CB . GLN A 1 313 ? 68.058 150.772 -1.633 1.00 227.22 ? 312 GLN A CB 1 ATOM 2486 C CG . GLN A 1 313 ? 67.729 151.724 -2.781 1.00 227.22 ? 312 GLN A CG 1 ATOM 2487 C CD . GLN A 1 313 ? 67.246 150.979 -4.011 1.00 227.22 ? 312 GLN A CD 1 ATOM 2488 O OE1 . GLN A 1 313 ? 68.033 150.343 -4.718 1.00 227.22 ? 312 GLN A OE1 1 ATOM 2489 N NE2 . GLN A 1 313 ? 65.943 151.045 -4.267 1.00 227.22 ? 312 GLN A NE2 1 ATOM 2490 N N . PHE A 1 314 ? 65.767 151.825 0.025 1.00 227.22 ? 313 PHE A N 1 ATOM 2491 C CA . PHE A 1 314 ? 64.539 152.563 0.313 1.00 227.22 ? 313 PHE A CA 1 ATOM 2492 C C . PHE A 1 314 ? 64.688 153.306 1.628 1.00 227.22 ? 313 PHE A C 1 ATOM 2493 O O . PHE A 1 314 ? 64.353 154.490 1.719 1.00 227.22 ? 313 PHE A O 1 ATOM 2494 C CB . PHE A 1 314 ? 63.362 151.576 0.379 1.00 227.22 ? 313 PHE A CB 1 ATOM 2495 C CG . PHE A 1 314 ? 62.007 152.223 0.526 1.00 227.22 ? 313 PHE A CG 1 ATOM 2496 C CD1 . PHE A 1 314 ? 61.528 153.113 -0.435 1.00 227.22 ? 313 PHE A CD1 1 ATOM 2497 C CD2 . PHE A 1 314 ? 61.193 151.903 1.605 1.00 227.22 ? 313 PHE A CD2 1 ATOM 2498 C CE1 . PHE A 1 314 ? 60.268 153.699 -0.311 1.00 227.22 ? 313 PHE A CE1 1 ATOM 2499 C CE2 . PHE A 1 314 ? 59.933 152.484 1.741 1.00 227.22 ? 313 PHE A CE2 1 ATOM 2500 C CZ . PHE A 1 314 ? 59.469 153.384 0.776 1.00 227.22 ? 313 PHE A CZ 1 ATOM 2501 N N . ARG A 1 315 ? 65.221 152.592 2.626 1.00 227.22 ? 314 ARG A N 1 ATOM 2502 C CA . ARG A 1 315 ? 65.467 153.104 3.983 1.00 227.22 ? 314 ARG A CA 1 ATOM 2503 C C . ARG A 1 315 ? 66.381 154.330 3.981 1.00 227.22 ? 314 ARG A C 1 ATOM 2504 O O . ARG A 1 315 ? 66.260 155.198 4.857 1.00 227.22 ? 314 ARG A O 1 ATOM 2505 C CB . ARG A 1 315 ? 66.050 151.995 4.879 1.00 227.22 ? 314 ARG A CB 1 ATOM 2506 C CG . ARG A 1 315 ? 66.404 152.419 6.299 1.00 227.22 ? 314 ARG A CG 1 ATOM 2507 C CD . ARG A 1 315 ? 66.457 151.230 7.253 1.00 227.22 ? 314 ARG A CD 1 ATOM 2508 N NE . ARG A 1 315 ? 67.809 150.711 7.486 1.00 227.22 ? 314 ARG A NE 1 ATOM 2509 C CZ . ARG A 1 315 ? 68.140 149.420 7.486 1.00 227.22 ? 314 ARG A CZ 1 ATOM 2510 N NH1 . ARG A 1 315 ? 67.223 148.483 7.265 1.00 227.22 ? 314 ARG A NH1 1 ATOM 2511 N NH2 . ARG A 1 315 ? 69.397 149.060 7.718 1.00 227.22 ? 314 ARG A NH2 1 ATOM 2512 N N . ASN A 1 316 ? 67.287 154.386 2.999 1.00 227.22 ? 315 ASN A N 1 ATOM 2513 C CA . ASN A 1 316 ? 68.191 155.529 2.826 1.00 227.22 ? 315 ASN A CA 1 ATOM 2514 C C . ASN A 1 316 ? 67.666 156.574 1.838 1.00 227.22 ? 315 ASN A C 1 ATOM 2515 O O . ASN A 1 316 ? 68.119 157.719 1.848 1.00 227.22 ? 315 ASN A O 1 ATOM 2516 C CB . ASN A 1 316 ? 69.615 155.068 2.473 1.00 227.22 ? 315 ASN A CB 1 ATOM 2517 C CG . ASN A 1 316 ? 70.444 154.713 3.711 1.00 227.22 ? 315 ASN A CG 1 ATOM 2518 O OD1 . ASN A 1 316 ? 70.708 153.539 3.981 1.00 227.22 ? 315 ASN A OD1 1 ATOM 2519 N ND2 . ASN A 1 316 ? 70.848 155.729 4.470 1.00 227.22 ? 315 ASN A ND2 1 ATOM 2520 N N . CYS A 1 317 ? 66.711 156.180 0.998 1.00 227.22 ? 316 CYS A N 1 ATOM 2521 C CA . CYS A 1 317 ? 66.012 157.131 0.135 1.00 227.22 ? 316 CYS A CA 1 ATOM 2522 C C . CYS A 1 317 ? 65.024 157.930 0.981 1.00 227.22 ? 316 CYS A C 1 ATOM 2523 O O . CYS A 1 317 ? 65.114 159.157 1.058 1.00 227.22 ? 316 CYS A O 1 ATOM 2524 C CB . CYS A 1 317 ? 65.309 156.426 -1.045 1.00 227.22 ? 316 CYS A CB 1 ATOM 2525 S SG . CYS A 1 317 ? 66.203 156.447 -2.661 1.00 227.22 ? 316 CYS A SG 1 ATOM 2526 N N . MET A 1 318 ? 64.107 157.212 1.630 1.00 227.22 ? 317 MET A N 1 ATOM 2527 C CA . MET A 1 318 ? 63.075 157.798 2.493 1.00 227.22 ? 317 MET A CA 1 ATOM 2528 C C . MET A 1 318 ? 63.633 158.792 3.510 1.00 227.22 ? 317 MET A C 1 ATOM 2529 O O . MET A 1 318 ? 63.221 159.958 3.533 1.00 227.22 ? 317 MET A O 1 ATOM 2530 C CB . MET A 1 318 ? 62.297 156.688 3.207 1.00 227.22 ? 317 MET A CB 1 ATOM 2531 C CG . MET A 1 318 ? 61.315 157.165 4.269 1.00 227.22 ? 317 MET A CG 1 ATOM 2532 S SD . MET A 1 318 ? 60.457 155.781 5.041 1.00 227.22 ? 317 MET A SD 1 ATOM 2533 C CE . MET A 1 318 ? 61.837 154.738 5.537 1.00 227.22 ? 317 MET A CE 1 ATOM 2534 N N . VAL A 1 319 ? 64.559 158.315 4.344 1.00 227.22 ? 318 VAL A N 1 ATOM 2535 C CA . VAL A 1 319 ? 65.289 159.163 5.285 1.00 227.22 ? 318 VAL A CA 1 ATOM 2536 C C . VAL A 1 319 ? 65.704 160.472 4.601 1.00 227.22 ? 318 VAL A C 1 ATOM 2537 O O . VAL A 1 319 ? 65.468 161.555 5.151 1.00 227.22 ? 318 VAL A O 1 ATOM 2538 C CB . VAL A 1 319 ? 66.528 158.422 5.877 1.00 227.22 ? 318 VAL A CB 1 ATOM 2539 C CG1 . VAL A 1 319 ? 67.481 159.388 6.570 1.00 227.22 ? 318 VAL A CG1 1 ATOM 2540 C CG2 . VAL A 1 319 ? 66.082 157.341 6.838 1.00 227.22 ? 318 VAL A CG2 1 ATOM 2541 N N . THR A 1 320 ? 66.266 160.355 3.389 1.00 227.22 ? 319 THR A N 1 ATOM 2542 C CA . THR A 1 320 ? 66.865 161.482 2.660 1.00 227.22 ? 319 THR A CA 1 ATOM 2543 C C . THR A 1 320 ? 65.816 162.463 2.155 1.00 227.22 ? 319 THR A C 1 ATOM 2544 O O . THR A 1 320 ? 66.096 163.653 1.986 1.00 227.22 ? 319 THR A O 1 ATOM 2545 C CB . THR A 1 320 ? 67.714 161.008 1.475 1.00 227.22 ? 319 THR A CB 1 ATOM 2546 O OG1 . THR A 1 320 ? 67.647 159.584 1.364 1.00 227.22 ? 319 THR A OG1 1 ATOM 2547 C CG2 . THR A 1 320 ? 69.155 161.443 1.640 1.00 227.22 ? 319 THR A CG2 1 ATOM 2548 N N . THR A 1 321 ? 64.611 161.956 1.917 1.00 227.22 ? 320 THR A N 1 ATOM 2549 C CA . THR A 1 321 ? 63.479 162.805 1.589 1.00 227.22 ? 320 THR A CA 1 ATOM 2550 C C . THR A 1 321 ? 63.101 163.639 2.811 1.00 227.22 ? 320 THR A C 1 ATOM 2551 O O . THR A 1 321 ? 62.683 164.791 2.668 1.00 227.22 ? 320 THR A O 1 ATOM 2552 C CB . THR A 1 321 ? 62.254 161.975 1.149 1.00 227.22 ? 320 THR A CB 1 ATOM 2553 O OG1 . THR A 1 321 ? 62.679 160.860 0.357 1.00 227.22 ? 320 THR A OG1 1 ATOM 2554 C CG2 . THR A 1 321 ? 61.291 162.825 0.342 1.00 227.22 ? 320 THR A CG2 1 ATOM 2555 N N . LEU A 1 322 ? 63.291 163.054 4.001 1.00 227.22 ? 321 LEU A N 1 ATOM 2556 C CA . LEU A 1 322 ? 62.750 163.571 5.278 1.00 227.22 ? 321 LEU A CA 1 ATOM 2557 C C . LEU A 1 322 ? 63.596 164.587 6.055 1.00 227.22 ? 321 LEU A C 1 ATOM 2558 O O . LEU A 1 322 ? 63.053 165.426 6.781 1.00 227.22 ? 321 LEU A O 1 ATOM 2559 C CB . LEU A 1 322 ? 62.372 162.409 6.196 1.00 227.22 ? 321 LEU A CB 1 ATOM 2560 C CG . LEU A 1 322 ? 61.221 161.532 5.698 1.00 227.22 ? 321 LEU A CG 1 ATOM 2561 C CD1 . LEU A 1 322 ? 60.850 160.510 6.767 1.00 227.22 ? 321 LEU A CD1 1 ATOM 2562 C CD2 . LEU A 1 322 ? 59.996 162.363 5.279 1.00 227.22 ? 321 LEU A CD2 1 ATOM 2563 N N . CYS A 1 323 ? 64.916 164.501 5.932 1.00 227.22 ? 322 CYS A N 1 ATOM 2564 C CA . CYS A 1 323 ? 65.776 165.596 6.371 1.00 227.22 ? 322 CYS A CA 1 ATOM 2565 C C . CYS A 1 323 ? 65.743 166.707 5.314 1.00 227.22 ? 322 CYS A C 1 ATOM 2566 O O . CYS A 1 323 ? 65.851 167.889 5.660 1.00 227.22 ? 322 CYS A O 1 ATOM 2567 C CB . CYS A 1 323 ? 67.224 165.135 6.563 1.00 227.22 ? 322 CYS A CB 1 ATOM 2568 S SG . CYS A 1 323 ? 67.458 163.363 6.784 1.00 227.22 ? 322 CYS A SG 1 ATOM 2569 N N . CYS A 1 324 ? 65.553 166.298 4.045 1.00 227.22 ? 323 CYS A N 1 ATOM 2570 C CA . CYS A 1 324 ? 65.772 167.094 2.806 1.00 227.22 ? 323 CYS A CA 1 ATOM 2571 C C . CYS A 1 324 ? 67.255 167.267 2.470 1.00 227.22 ? 323 CYS A C 1 ATOM 2572 O O . CYS A 1 324 ? 67.803 168.377 2.552 1.00 227.22 ? 323 CYS A O 1 ATOM 2573 C CB . CYS A 1 324 ? 65.027 168.436 2.792 1.00 227.22 ? 323 CYS A CB 1 ATOM 2574 S SG . CYS A 1 324 ? 63.451 168.368 1.939 1.00 227.22 ? 323 CYS A SG 1 ATOM 2575 N N . GLY A 1 325 ? 67.896 166.159 2.098 1.00 227.22 ? 324 GLY A N 1 ATOM 2576 C CA . GLY A 1 325 ? 69.287 166.182 1.655 1.00 227.22 ? 324 GLY A CA 1 ATOM 2577 C C . GLY A 1 325 ? 70.178 165.102 2.239 1.00 227.22 ? 324 GLY A C 1 ATOM 2578 O O . GLY A 1 325 ? 70.399 164.064 1.609 1.00 227.22 ? 324 GLY A O 1 ATOM 2579 N N . LYS A 1 326 ? 70.680 165.352 3.451 1.00 227.22 ? 325 LYS A N 1 ATOM 2580 C CA . LYS A 1 326 ? 71.744 164.537 4.074 1.00 227.22 ? 325 LYS A CA 1 ATOM 2581 C C . LYS A 1 326 ? 71.257 163.660 5.249 1.00 227.22 ? 325 LYS A C 1 ATOM 2582 O O . LYS A 1 326 ? 70.488 164.121 6.109 1.00 227.22 ? 325 LYS A O 1 ATOM 2583 C CB . LYS A 1 326 ? 72.914 165.429 4.544 1.00 227.22 ? 325 LYS A CB 1 ATOM 2584 C CG . LYS A 1 326 ? 73.083 166.778 3.816 1.00 227.22 ? 325 LYS A CG 1 ATOM 2585 C CD . LYS A 1 326 ? 72.136 167.857 4.367 1.00 227.22 ? 325 LYS A CD 1 ATOM 2586 C CE . LYS A 1 326 ? 72.381 169.218 3.730 1.00 227.22 ? 325 LYS A CE 1 ATOM 2587 N NZ . LYS A 1 326 ? 71.289 170.184 4.054 1.00 227.22 ? 325 LYS A NZ 1 ATOM 2588 N N . ASN A 1 327 ? 71.724 162.408 5.282 1.00 227.22 ? 326 ASN A N 1 ATOM 2589 C CA . ASN A 1 327 ? 71.356 161.450 6.338 1.00 227.22 ? 326 ASN A CA 1 ATOM 2590 C C . ASN A 1 327 ? 72.413 161.292 7.442 1.00 227.22 ? 326 ASN A C 1 ATOM 2591 O O . ASN A 1 327 ? 72.365 161.983 8.476 1.00 227.22 ? 326 ASN A O 1 ATOM 2592 C CB . ASN A 1 327 ? 70.976 160.073 5.745 1.00 227.22 ? 326 ASN A CB 1 ATOM 2593 C CG . ASN A 1 327 ? 72.153 159.353 5.044 1.00 227.22 ? 326 ASN A CG 1 ATOM 2594 O OD1 . ASN A 1 327 ? 73.337 159.598 5.330 1.00 227.22 ? 326 ASN A OD1 1 ATOM 2595 N ND2 . ASN A 1 327 ? 71.809 158.440 4.134 1.00 227.22 ? 326 ASN A ND2 1 ATOM 2596 N N . ASP A 1 331 ? 68.906 159.869 -1.524 1.00 227.22 ? 330 ASP A N 1 ATOM 2597 C CA . ASP A 1 331 ? 68.766 160.558 -2.796 1.00 227.22 ? 330 ASP A CA 1 ATOM 2598 C C . ASP A 1 331 ? 68.463 159.551 -3.895 1.00 227.22 ? 330 ASP A C 1 ATOM 2599 O O . ASP A 1 331 ? 68.546 158.334 -3.685 1.00 227.22 ? 330 ASP A O 1 ATOM 2600 C CB . ASP A 1 331 ? 70.034 161.360 -3.128 1.00 227.22 ? 330 ASP A CB 1 ATOM 2601 N N . ASP A 1 332 ? 68.064 160.088 -5.048 1.00 227.22 ? 331 ASP A N 1 ATOM 2602 C CA . ASP A 1 332 ? 67.901 159.352 -6.303 1.00 227.22 ? 331 ASP A CA 1 ATOM 2603 C C . ASP A 1 332 ? 67.568 160.349 -7.412 1.00 227.22 ? 331 ASP A C 1 ATOM 2604 O O . ASP A 1 332 ? 68.390 160.592 -8.297 1.00 227.22 ? 331 ASP A O 1 ATOM 2605 C CB . ASP A 1 332 ? 66.820 158.283 -6.188 1.00 227.22 ? 331 ASP A CB 1 ATOM 2606 N N . GLU A 1 333 ? 66.381 160.949 -7.339 1.00 227.22 ? 332 GLU A N 1 HETATM 2607 C C1 . NAG B 2 . ? 12.757 139.768 14.367 1.00 227.22 ? 1335 NAG A C1 1 HETATM 2608 C C2 . NAG B 2 . ? 12.614 140.389 12.975 1.00 227.22 ? 1335 NAG A C2 1 HETATM 2609 C C3 . NAG B 2 . ? 11.864 141.726 13.009 1.00 227.22 ? 1335 NAG A C3 1 HETATM 2610 C C4 . NAG B 2 . ? 10.540 141.642 13.775 1.00 227.22 ? 1335 NAG A C4 1 HETATM 2611 C C5 . NAG B 2 . ? 10.918 141.073 15.152 1.00 227.22 ? 1335 NAG A C5 1 HETATM 2612 C C6 . NAG B 2 . ? 9.765 141.069 16.163 1.00 227.22 ? 1335 NAG A C6 1 HETATM 2613 C C7 . NAG B 2 . ? 14.137 140.360 11.068 1.00 227.22 ? 1335 NAG A C7 1 HETATM 2614 C C8 . NAG B 2 . ? 14.669 141.534 10.300 1.00 227.22 ? 1335 NAG A C8 1 HETATM 2615 N N2 . NAG B 2 . ? 13.924 140.554 12.370 1.00 227.22 ? 1335 NAG A N2 1 HETATM 2616 O O3 . NAG B 2 . ? 11.647 142.165 11.692 1.00 227.22 ? 1335 NAG A O3 1 HETATM 2617 O O4 . NAG B 2 . ? 9.938 142.933 13.863 1.00 227.22 ? 1335 NAG A O4 1 HETATM 2618 O O5 . NAG B 2 . ? 11.487 139.774 15.000 1.00 227.22 ? 1335 NAG A O5 1 HETATM 2619 O O6 . NAG B 2 . ? 9.556 139.777 16.689 1.00 227.22 ? 1335 NAG A O6 1 HETATM 2620 O O7 . NAG B 2 . ? 13.922 139.290 10.499 1.00 227.22 ? 1335 NAG A O7 1 HETATM 2621 C C1 . NAG C 2 . ? 8.531 142.976 13.496 1.00 227.22 ? 1336 NAG A C1 1 HETATM 2622 C C2 . NAG C 2 . ? 7.741 144.008 14.332 1.00 227.22 ? 1336 NAG A C2 1 HETATM 2623 C C3 . NAG C 2 . ? 6.286 144.177 13.840 1.00 227.22 ? 1336 NAG A C3 1 HETATM 2624 C C4 . NAG C 2 . ? 6.147 144.300 12.312 1.00 227.22 ? 1336 NAG A C4 1 HETATM 2625 C C5 . NAG C 2 . ? 7.013 143.207 11.645 1.00 227.22 ? 1336 NAG A C5 1 HETATM 2626 C C6 . NAG C 2 . ? 7.010 143.225 10.106 1.00 227.22 ? 1336 NAG A C6 1 HETATM 2627 C C7 . NAG C 2 . ? 8.223 144.403 16.744 1.00 227.22 ? 1336 NAG A C7 1 HETATM 2628 C C8 . NAG C 2 . ? 7.376 145.519 17.294 1.00 227.22 ? 1336 NAG A C8 1 HETATM 2629 N N2 . NAG C 2 . ? 7.713 143.657 15.752 1.00 227.22 ? 1336 NAG A N2 1 HETATM 2630 O O3 . NAG C 2 . ? 5.663 145.281 14.475 1.00 227.22 ? 1336 NAG A O3 1 HETATM 2631 O O4 . NAG C 2 . ? 4.771 144.168 11.942 1.00 227.22 ? 1336 NAG A O4 1 HETATM 2632 O O5 . NAG C 2 . ? 8.357 143.260 12.119 1.00 227.22 ? 1336 NAG A O5 1 HETATM 2633 O O6 . NAG C 2 . ? 7.444 144.460 9.567 1.00 227.22 ? 1336 NAG A O6 1 HETATM 2634 O O7 . NAG C 2 . ? 9.335 144.198 17.231 1.00 227.22 ? 1336 NAG A O7 1 HETATM 2635 C C1 . BMA D 3 . ? 4.135 145.349 11.363 1.00 227.22 ? 1337 BMA A C1 1 HETATM 2636 C C2 . BMA D 3 . ? 4.000 145.185 9.834 1.00 227.22 ? 1337 BMA A C2 1 HETATM 2637 C C3 . BMA D 3 . ? 3.094 146.266 9.237 1.00 227.22 ? 1337 BMA A C3 1 HETATM 2638 C C4 . BMA D 3 . ? 1.714 146.134 9.869 1.00 227.22 ? 1337 BMA A C4 1 HETATM 2639 C C5 . BMA D 3 . ? 1.834 146.424 11.376 1.00 227.22 ? 1337 BMA A C5 1 HETATM 2640 C C6 . BMA D 3 . ? 0.512 146.141 12.100 1.00 227.22 ? 1337 BMA A C6 1 HETATM 2641 O O2 . BMA D 3 . ? 3.499 143.874 9.503 1.00 227.22 ? 1337 BMA A O2 1 HETATM 2642 O O3 . BMA D 3 . ? 3.000 146.179 7.804 1.00 227.22 ? 1337 BMA A O3 1 HETATM 2643 O O4 . BMA D 3 . ? 0.788 147.000 9.190 1.00 227.22 ? 1337 BMA A O4 1 HETATM 2644 O O5 . BMA D 3 . ? 2.881 145.658 12.027 1.00 227.22 ? 1337 BMA A O5 1 HETATM 2645 O O6 . BMA D 3 . ? -0.226 147.362 12.307 1.00 227.22 ? 1337 BMA A O6 1 HETATM 2646 C C1 . NAG E 2 . ? 21.820 125.469 14.738 1.00 227.22 ? 1338 NAG A C1 1 HETATM 2647 C C2 . NAG E 2 . ? 21.985 124.493 13.564 1.00 227.22 ? 1338 NAG A C2 1 HETATM 2648 C C3 . NAG E 2 . ? 22.300 123.032 13.949 1.00 227.22 ? 1338 NAG A C3 1 HETATM 2649 C C4 . NAG E 2 . ? 22.414 122.688 15.451 1.00 227.22 ? 1338 NAG A C4 1 HETATM 2650 C C5 . NAG E 2 . ? 22.450 123.910 16.398 1.00 227.22 ? 1338 NAG A C5 1 HETATM 2651 C C6 . NAG E 2 . ? 23.458 123.744 17.539 1.00 227.22 ? 1338 NAG A C6 1 HETATM 2652 C C7 . NAG E 2 . ? 19.653 123.959 12.916 1.00 227.22 ? 1338 NAG A C7 1 HETATM 2653 C C8 . NAG E 2 . ? 19.331 122.713 12.135 1.00 227.22 ? 1338 NAG A C8 1 HETATM 2654 N N2 . NAG E 2 . ? 20.826 124.553 12.677 1.00 227.22 ? 1338 NAG A N2 1 HETATM 2655 O O3 . NAG E 2 . ? 23.465 122.604 13.268 1.00 227.22 ? 1338 NAG A O3 1 HETATM 2656 O O4 . NAG E 2 . ? 21.327 121.840 15.813 1.00 227.22 ? 1338 NAG A O4 1 HETATM 2657 O O5 . NAG E 2 . ? 22.763 125.119 15.726 1.00 227.22 ? 1338 NAG A O5 1 HETATM 2658 O O6 . NAG E 2 . ? 23.056 124.501 18.664 1.00 227.22 ? 1338 NAG A O6 1 HETATM 2659 O O7 . NAG E 2 . ? 18.848 124.394 13.734 1.00 227.22 ? 1338 NAG A O7 1 HETATM 2660 C C1 . NAG F 2 . ? 21.674 120.430 15.856 1.00 227.22 ? 1339 NAG A C1 1 HETATM 2661 C C2 . NAG F 2 . ? 21.553 119.829 17.270 1.00 227.22 ? 1339 NAG A C2 1 HETATM 2662 C C3 . NAG F 2 . ? 21.959 118.334 17.284 1.00 227.22 ? 1339 NAG A C3 1 HETATM 2663 C C4 . NAG F 2 . ? 21.564 117.526 16.032 1.00 227.22 ? 1339 NAG A C4 1 HETATM 2664 C C5 . NAG F 2 . ? 21.348 118.342 14.738 1.00 227.22 ? 1339 NAG A C5 1 HETATM 2665 C C6 . NAG F 2 . ? 20.387 117.632 13.773 1.00 227.22 ? 1339 NAG A C6 1 HETATM 2666 C C7 . NAG F 2 . ? 21.747 121.271 19.319 1.00 227.22 ? 1339 NAG A C7 1 HETATM 2667 C C8 . NAG F 2 . ? 22.694 121.607 20.440 1.00 227.22 ? 1339 NAG A C8 1 HETATM 2668 N N2 . NAG F 2 . ? 22.293 120.616 18.268 1.00 227.22 ? 1339 NAG A N2 1 HETATM 2669 O O3 . NAG F 2 . ? 21.403 117.669 18.408 1.00 227.22 ? 1339 NAG A O3 1 HETATM 2670 O O4 . NAG F 2 . ? 22.560 116.541 15.812 1.00 227.22 ? 1339 NAG A O4 1 HETATM 2671 O O5 . NAG F 2 . ? 20.856 119.654 14.994 1.00 227.22 ? 1339 NAG A O5 1 HETATM 2672 O O6 . NAG F 2 . ? 20.916 117.559 12.460 1.00 227.22 ? 1339 NAG A O6 1 HETATM 2673 O O7 . NAG F 2 . ? 20.555 121.611 19.417 1.00 227.22 ? 1339 NAG A O7 1 HETATM 2674 C C1 . RET G 4 . ? 40.533 135.391 -0.163 1.00 227.22 ? 1332 RET A C1 1 HETATM 2675 C C2 . RET G 4 . ? 41.458 134.258 0.307 1.00 227.22 ? 1332 RET A C2 1 HETATM 2676 C C3 . RET G 4 . ? 42.803 134.750 0.852 1.00 227.22 ? 1332 RET A C3 1 HETATM 2677 C C4 . RET G 4 . ? 43.263 136.095 0.293 1.00 227.22 ? 1332 RET A C4 1 HETATM 2678 C C5 . RET G 4 . ? 42.192 137.156 0.403 1.00 227.22 ? 1332 RET A C5 1 HETATM 2679 C C6 . RET G 4 . ? 40.900 136.834 0.209 1.00 227.22 ? 1332 RET A C6 1 HETATM 2680 C C7 . RET G 4 . ? 39.846 137.881 0.281 1.00 227.22 ? 1332 RET A C7 1 HETATM 2681 C C8 . RET G 4 . ? 39.117 138.100 1.372 1.00 227.22 ? 1332 RET A C8 1 HETATM 2682 C C9 . RET G 4 . ? 38.074 139.140 1.392 1.00 227.22 ? 1332 RET A C9 1 HETATM 2683 C C10 . RET G 4 . ? 38.383 140.358 1.878 1.00 227.22 ? 1332 RET A C10 1 HETATM 2684 C C11 . RET G 4 . ? 37.436 141.473 1.963 1.00 227.22 ? 1332 RET A C11 1 HETATM 2685 C C12 . RET G 4 . ? 37.105 142.116 3.091 1.00 227.22 ? 1332 RET A C12 1 HETATM 2686 C C13 . RET G 4 . ? 37.600 141.832 4.463 1.00 227.22 ? 1332 RET A C13 1 HETATM 2687 C C14 . RET G 4 . ? 37.267 142.669 5.459 1.00 227.22 ? 1332 RET A C14 1 HETATM 2688 C C15 . RET G 4 . ? 37.728 142.423 6.823 1.00 227.22 ? 1332 RET A C15 1 HETATM 2689 C C16 . RET G 4 . ? 39.128 135.160 -0.729 1.00 227.22 ? 1332 RET A C16 1 HETATM 2690 C C17 . RET G 4 . ? 39.824 135.148 1.168 1.00 227.22 ? 1332 RET A C17 1 HETATM 2691 C C18 . RET G 4 . ? 42.623 138.556 0.743 1.00 227.22 ? 1332 RET A C18 1 HETATM 2692 C C19 . RET G 4 . ? 36.701 138.792 0.884 1.00 227.22 ? 1332 RET A C19 1 HETATM 2693 C C20 . RET G 4 . ? 38.452 140.636 4.787 1.00 227.22 ? 1332 RET A C20 1 HETATM 2694 C C1 . PLM H 5 . ? 65.782 165.093 11.022 1.00 227.22 ? 1333 PLM A C1 1 HETATM 2695 O O1 . PLM H 5 . ? 66.665 165.776 11.587 1.00 227.22 ? 1333 PLM A O1 1 HETATM 2696 C C2 . PLM H 5 . ? 64.615 164.536 11.801 1.00 227.22 ? 1333 PLM A C2 1 HETATM 2697 C C3 . PLM H 5 . ? 63.312 165.208 11.369 1.00 227.22 ? 1333 PLM A C3 1 HETATM 2698 C C4 . PLM H 5 . ? 62.303 164.158 10.884 1.00 227.22 ? 1333 PLM A C4 1 HETATM 2699 C C5 . PLM H 5 . ? 60.843 164.612 11.081 1.00 227.22 ? 1333 PLM A C5 1 HETATM 2700 C C6 . PLM H 5 . ? 59.876 163.561 10.533 1.00 227.22 ? 1333 PLM A C6 1 HETATM 2701 C C7 . PLM H 5 . ? 58.542 164.160 10.079 1.00 227.22 ? 1333 PLM A C7 1 HETATM 2702 C C8 . PLM H 5 . ? 57.763 163.178 9.201 1.00 227.22 ? 1333 PLM A C8 1 HETATM 2703 C C9 . PLM H 5 . ? 56.245 163.289 9.376 1.00 227.22 ? 1333 PLM A C9 1 HETATM 2704 C CA . PLM H 5 . ? 55.446 162.336 8.480 1.00 227.22 ? 1333 PLM A CA 1 HETATM 2705 C CB . PLM H 5 . ? 55.595 160.852 8.827 1.00 227.22 ? 1333 PLM A CB 1 HETATM 2706 C CC . PLM H 5 . ? 54.269 160.109 8.679 1.00 227.22 ? 1333 PLM A CC 1 HETATM 2707 C CD . PLM H 5 . ? 54.447 158.597 8.550 1.00 227.22 ? 1333 PLM A CD 1 HETATM 2708 C CE . PLM H 5 . ? 54.337 157.893 9.901 1.00 227.22 ? 1333 PLM A CE 1 HETATM 2709 C CF . PLM H 5 . ? 52.949 157.328 10.201 1.00 227.22 ? 1333 PLM A CF 1 HETATM 2710 C CG . PLM H 5 . ? 52.397 157.830 11.536 1.00 227.22 ? 1333 PLM A CG 1 HETATM 2711 C C1 . PLM I 5 . ? 62.986 170.080 6.864 1.00 227.22 ? 1334 PLM A C1 1 HETATM 2712 O O1 . PLM I 5 . ? 64.261 170.006 6.944 1.00 227.22 ? 1334 PLM A O1 1 HETATM 2713 C C2 . PLM I 5 . ? 62.164 168.813 6.952 1.00 227.22 ? 1334 PLM A C2 1 HETATM 2714 C C3 . PLM I 5 . ? 61.909 168.261 5.549 1.00 227.22 ? 1334 PLM A C3 1 HETATM 2715 C C4 . PLM I 5 . ? 60.434 167.939 5.302 1.00 227.22 ? 1334 PLM A C4 1 HETATM 2716 C C5 . PLM I 5 . ? 60.187 166.431 5.225 1.00 227.22 ? 1334 PLM A C5 1 HETATM 2717 C C6 . PLM I 5 . ? 59.013 166.092 4.310 1.00 227.22 ? 1334 PLM A C6 1 HETATM 2718 C C7 . PLM I 5 . ? 57.783 165.642 5.091 1.00 227.22 ? 1334 PLM A C7 1 HETATM 2719 C C8 . PLM I 5 . ? 56.518 166.301 4.548 1.00 227.22 ? 1334 PLM A C8 1 HETATM 2720 C C9 . PLM I 5 . ? 55.262 165.692 5.167 1.00 227.22 ? 1334 PLM A C9 1 HETATM 2721 C CA . PLM I 5 . ? 54.668 164.580 4.307 1.00 227.22 ? 1334 PLM A CA 1 HETATM 2722 C CB . PLM I 5 . ? 54.813 163.222 4.985 1.00 227.22 ? 1334 PLM A CB 1 HETATM 2723 C CC . PLM I 5 . ? 53.927 162.164 4.330 1.00 227.22 ? 1334 PLM A CC 1 HETATM 2724 C CD . PLM I 5 . ? 52.802 161.705 5.254 1.00 227.22 ? 1334 PLM A CD 1 HETATM 2725 C CE . PLM I 5 . ? 51.424 161.990 4.655 1.00 227.22 ? 1334 PLM A CE 1 HETATM 2726 C CF . PLM I 5 . ? 50.792 163.249 5.245 1.00 227.22 ? 1334 PLM A CF 1 HETATM 2727 C CG . PLM I 5 . ? 50.908 164.449 4.309 1.00 227.22 ? 1334 PLM A CG 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 ACE 1 0 0 ACE ACE A . n A 1 2 MET 2 1 1 MET MET A . n A 1 3 ASN 3 2 2 ASN ASN A . n A 1 4 GLY 4 3 3 GLY GLY A . n A 1 5 THR 5 4 4 THR THR A . n A 1 6 GLU 6 5 5 GLU GLU A . n A 1 7 GLY 7 6 6 GLY GLY A . n A 1 8 PRO 8 7 7 PRO PRO A . n A 1 9 ASN 9 8 8 ASN ASN A . n A 1 10 PHE 10 9 9 PHE PHE A . n A 1 11 TYR 11 10 10 TYR TYR A . n A 1 12 VAL 12 11 11 VAL VAL A . n A 1 13 PRO 13 12 12 PRO PRO A . n A 1 14 PHE 14 13 13 PHE PHE A . n A 1 15 SER 15 14 14 SER SER A . n A 1 16 ASN 16 15 15 ASN ASN A . n A 1 17 LYS 17 16 16 LYS LYS A . n A 1 18 THR 18 17 17 THR THR A . n A 1 19 GLY 19 18 18 GLY GLY A . n A 1 20 VAL 20 19 19 VAL VAL A . n A 1 21 VAL 21 20 20 VAL VAL A . n A 1 22 ARG 22 21 21 ARG ARG A . n A 1 23 SER 23 22 22 SER SER A . n A 1 24 PRO 24 23 23 PRO PRO A . n A 1 25 PHE 25 24 24 PHE PHE A . n A 1 26 GLU 26 25 25 GLU GLU A . n A 1 27 ALA 27 26 26 ALA ALA A . n A 1 28 PRO 28 27 27 PRO PRO A . n A 1 29 GLN 29 28 28 GLN GLN A . n A 1 30 TYR 30 29 29 TYR TYR A . n A 1 31 TYR 31 30 30 TYR TYR A . n A 1 32 LEU 32 31 31 LEU LEU A . n A 1 33 ALA 33 32 32 ALA ALA A . n A 1 34 GLU 34 33 33 GLU GLU A . n A 1 35 PRO 35 34 34 PRO PRO A . n A 1 36 TRP 36 35 35 TRP TRP A . n A 1 37 GLN 37 36 36 GLN GLN A . n A 1 38 PHE 38 37 37 PHE PHE A . n A 1 39 SER 39 38 38 SER SER A . n A 1 40 MET 40 39 39 MET MET A . n A 1 41 LEU 41 40 40 LEU LEU A . n A 1 42 ALA 42 41 41 ALA ALA A . n A 1 43 ALA 43 42 42 ALA ALA A . n A 1 44 TYR 44 43 43 TYR TYR A . n A 1 45 MET 45 44 44 MET MET A . n A 1 46 PHE 46 45 45 PHE PHE A . n A 1 47 LEU 47 46 46 LEU LEU A . n A 1 48 LEU 48 47 47 LEU LEU A . n A 1 49 ILE 49 48 48 ILE ILE A . n A 1 50 MET 50 49 49 MET MET A . n A 1 51 LEU 51 50 50 LEU LEU A . n A 1 52 GLY 52 51 51 GLY GLY A . n A 1 53 PHE 53 52 52 PHE PHE A . n A 1 54 PRO 54 53 53 PRO PRO A . n A 1 55 ILE 55 54 54 ILE ILE A . n A 1 56 ASN 56 55 55 ASN ASN A . n A 1 57 PHE 57 56 56 PHE PHE A . n A 1 58 LEU 58 57 57 LEU LEU A . n A 1 59 THR 59 58 58 THR THR A . n A 1 60 LEU 60 59 59 LEU LEU A . n A 1 61 TYR 61 60 60 TYR TYR A . n A 1 62 VAL 62 61 61 VAL VAL A . n A 1 63 THR 63 62 62 THR THR A . n A 1 64 VAL 64 63 63 VAL VAL A . n A 1 65 GLN 65 64 64 GLN GLN A . n A 1 66 HIS 66 65 65 HIS HIS A . n A 1 67 LYS 67 66 66 LYS LYS A . n A 1 68 LYS 68 67 67 LYS LYS A . n A 1 69 LEU 69 68 68 LEU LEU A . n A 1 70 ARG 70 69 69 ARG ARG A . n A 1 71 THR 71 70 70 THR THR A . n A 1 72 PRO 72 71 71 PRO PRO A . n A 1 73 LEU 73 72 72 LEU LEU A . n A 1 74 ASN 74 73 73 ASN ASN A . n A 1 75 TYR 75 74 74 TYR TYR A . n A 1 76 ILE 76 75 75 ILE ILE A . n A 1 77 LEU 77 76 76 LEU LEU A . n A 1 78 LEU 78 77 77 LEU LEU A . n A 1 79 ASN 79 78 78 ASN ASN A . n A 1 80 LEU 80 79 79 LEU LEU A . n A 1 81 ALA 81 80 80 ALA ALA A . n A 1 82 VAL 82 81 81 VAL VAL A . n A 1 83 ALA 83 82 82 ALA ALA A . n A 1 84 ASP 84 83 83 ASP ASP A . n A 1 85 LEU 85 84 84 LEU LEU A . n A 1 86 PHE 86 85 85 PHE PHE A . n A 1 87 MET 87 86 86 MET MET A . n A 1 88 VAL 88 87 87 VAL VAL A . n A 1 89 PHE 89 88 88 PHE PHE A . n A 1 90 GLY 90 89 89 GLY GLY A . n A 1 91 GLY 91 90 90 GLY GLY A . n A 1 92 PHE 92 91 91 PHE PHE A . n A 1 93 THR 93 92 92 THR THR A . n A 1 94 THR 94 93 93 THR THR A . n A 1 95 THR 95 94 94 THR THR A . n A 1 96 LEU 96 95 95 LEU LEU A . n A 1 97 TYR 97 96 96 TYR TYR A . n A 1 98 THR 98 97 97 THR THR A . n A 1 99 SER 99 98 98 SER SER A . n A 1 100 LEU 100 99 99 LEU LEU A . n A 1 101 HIS 101 100 100 HIS HIS A . n A 1 102 GLY 102 101 101 GLY GLY A . n A 1 103 TYR 103 102 102 TYR TYR A . n A 1 104 PHE 104 103 103 PHE PHE A . n A 1 105 VAL 105 104 104 VAL VAL A . n A 1 106 PHE 106 105 105 PHE PHE A . n A 1 107 GLY 107 106 106 GLY GLY A . n A 1 108 PRO 108 107 107 PRO PRO A . n A 1 109 THR 109 108 108 THR THR A . n A 1 110 GLY 110 109 109 GLY GLY A . n A 1 111 CYS 111 110 110 CYS CYS A . n A 1 112 ASN 112 111 111 ASN ASN A . n A 1 113 LEU 113 112 112 LEU LEU A . n A 1 114 GLU 114 113 113 GLU GLU A . n A 1 115 GLY 115 114 114 GLY GLY A . n A 1 116 PHE 116 115 115 PHE PHE A . n A 1 117 PHE 117 116 116 PHE PHE A . n A 1 118 ALA 118 117 117 ALA ALA A . n A 1 119 THR 119 118 118 THR THR A . n A 1 120 LEU 120 119 119 LEU LEU A . n A 1 121 GLY 121 120 120 GLY GLY A . n A 1 122 GLY 122 121 121 GLY GLY A . n A 1 123 GLU 123 122 122 GLU GLU A . n A 1 124 ILE 124 123 123 ILE ILE A . n A 1 125 ALA 125 124 124 ALA ALA A . n A 1 126 LEU 126 125 125 LEU LEU A . n A 1 127 TRP 127 126 126 TRP TRP A . n A 1 128 SER 128 127 127 SER SER A . n A 1 129 LEU 129 128 128 LEU LEU A . n A 1 130 VAL 130 129 129 VAL VAL A . n A 1 131 VAL 131 130 130 VAL VAL A . n A 1 132 LEU 132 131 131 LEU LEU A . n A 1 133 ALA 133 132 132 ALA ALA A . n A 1 134 ILE 134 133 133 ILE ILE A . n A 1 135 GLU 135 134 134 GLU GLU A . n A 1 136 ARG 136 135 135 ARG ARG A . n A 1 137 TYR 137 136 136 TYR TYR A . n A 1 138 VAL 138 137 137 VAL VAL A . n A 1 139 VAL 139 138 138 VAL VAL A . n A 1 140 VAL 140 139 139 VAL VAL A . n A 1 141 CYS 141 140 140 CYS CYS A . n A 1 142 LYS 142 141 141 LYS LYS A . n A 1 143 PRO 143 142 142 PRO PRO A . n A 1 144 MET 144 143 143 MET MET A . n A 1 145 SER 145 144 144 SER SER A . n A 1 146 ASN 146 145 145 ASN ASN A . n A 1 147 PHE 147 146 146 PHE PHE A . n A 1 148 ARG 148 147 147 ARG ARG A . n A 1 149 PHE 149 148 148 PHE PHE A . n A 1 150 GLY 150 149 149 GLY GLY A . n A 1 151 GLU 151 150 150 GLU GLU A . n A 1 152 ASN 152 151 151 ASN ASN A . n A 1 153 HIS 153 152 152 HIS HIS A . n A 1 154 ALA 154 153 153 ALA ALA A . n A 1 155 ILE 155 154 154 ILE ILE A . n A 1 156 MET 156 155 155 MET MET A . n A 1 157 GLY 157 156 156 GLY GLY A . n A 1 158 VAL 158 157 157 VAL VAL A . n A 1 159 ALA 159 158 158 ALA ALA A . n A 1 160 PHE 160 159 159 PHE PHE A . n A 1 161 THR 161 160 160 THR THR A . n A 1 162 TRP 162 161 161 TRP TRP A . n A 1 163 VAL 163 162 162 VAL VAL A . n A 1 164 MET 164 163 163 MET MET A . n A 1 165 ALA 165 164 164 ALA ALA A . n A 1 166 LEU 166 165 165 LEU LEU A . n A 1 167 ALA 167 166 166 ALA ALA A . n A 1 168 CYS 168 167 167 CYS CYS A . n A 1 169 ALA 169 168 168 ALA ALA A . n A 1 170 ALA 170 169 169 ALA ALA A . n A 1 171 PRO 171 170 170 PRO PRO A . n A 1 172 PRO 172 171 171 PRO PRO A . n A 1 173 LEU 173 172 172 LEU LEU A . n A 1 174 VAL 174 173 173 VAL VAL A . n A 1 175 GLY 175 174 174 GLY GLY A . n A 1 176 TRP 176 175 175 TRP TRP A . n A 1 177 SER 177 176 176 SER SER A . n A 1 178 ARG 178 177 177 ARG ARG A . n A 1 179 TYR 179 178 178 TYR TYR A . n A 1 180 ILE 180 179 179 ILE ILE A . n A 1 181 PRO 181 180 180 PRO PRO A . n A 1 182 GLU 182 181 181 GLU GLU A . n A 1 183 GLY 183 182 182 GLY GLY A . n A 1 184 MET 184 183 183 MET MET A . n A 1 185 GLN 185 184 184 GLN GLN A . n A 1 186 CYS 186 185 185 CYS CYS A . n A 1 187 SER 187 186 186 SER SER A . n A 1 188 CYS 188 187 187 CYS CYS A . n A 1 189 GLY 189 188 188 GLY GLY A . n A 1 190 ILE 190 189 189 ILE ILE A . n A 1 191 ASP 191 190 190 ASP ASP A . n A 1 192 TYR 192 191 191 TYR TYR A . n A 1 193 TYR 193 192 192 TYR TYR A . n A 1 194 THR 194 193 193 THR THR A . n A 1 195 PRO 195 194 194 PRO PRO A . n A 1 196 HIS 196 195 195 HIS HIS A . n A 1 197 GLU 197 196 196 GLU GLU A . n A 1 198 GLU 198 197 197 GLU GLU A . n A 1 199 THR 199 198 198 THR THR A . n A 1 200 ASN 200 199 199 ASN ASN A . n A 1 201 ASN 201 200 200 ASN ASN A . n A 1 202 GLU 202 201 201 GLU GLU A . n A 1 203 SER 203 202 202 SER SER A . n A 1 204 PHE 204 203 203 PHE PHE A . n A 1 205 VAL 205 204 204 VAL VAL A . n A 1 206 ILE 206 205 205 ILE ILE A . n A 1 207 TYR 207 206 206 TYR TYR A . n A 1 208 MET 208 207 207 MET MET A . n A 1 209 PHE 209 208 208 PHE PHE A . n A 1 210 VAL 210 209 209 VAL VAL A . n A 1 211 VAL 211 210 210 VAL VAL A . n A 1 212 HIS 212 211 211 HIS HIS A . n A 1 213 PHE 213 212 212 PHE PHE A . n A 1 214 ILE 214 213 213 ILE ILE A . n A 1 215 ILE 215 214 214 ILE ILE A . n A 1 216 PRO 216 215 215 PRO PRO A . n A 1 217 LEU 217 216 216 LEU LEU A . n A 1 218 ILE 218 217 217 ILE ILE A . n A 1 219 VAL 219 218 218 VAL VAL A . n A 1 220 ILE 220 219 219 ILE ILE A . n A 1 221 PHE 221 220 220 PHE PHE A . n A 1 222 PHE 222 221 221 PHE PHE A . n A 1 223 CYS 223 222 222 CYS CYS A . n A 1 224 TYR 224 223 223 TYR TYR A . n A 1 225 GLY 225 224 224 GLY GLY A . n A 1 226 GLN 226 225 225 GLN GLN A . n A 1 227 LEU 227 226 226 LEU LEU A . n A 1 228 VAL 228 227 227 VAL VAL A . n A 1 229 PHE 229 228 228 PHE PHE A . n A 1 230 THR 230 229 229 THR THR A . n A 1 231 VAL 231 230 230 VAL VAL A . n A 1 232 LYS 232 231 231 LYS LYS A . n A 1 233 GLU 233 232 232 GLU GLU A . n A 1 234 ALA 234 233 233 ALA ALA A . n A 1 235 ALA 235 234 234 ALA ALA A . n A 1 236 ALA 236 235 235 ALA ALA A . n A 1 237 GLN 237 236 236 GLN GLN A . n A 1 238 GLN 238 237 237 GLN GLN A . n A 1 239 GLN 239 238 238 GLN GLN A . n A 1 240 GLU 240 239 239 GLU GLU A . n A 1 241 SER 241 240 240 SER SER A . n A 1 242 ALA 242 241 241 ALA ALA A . n A 1 243 THR 243 242 242 THR THR A . n A 1 244 THR 244 243 243 THR THR A . n A 1 245 GLN 245 244 244 GLN GLN A . n A 1 246 LYS 246 245 245 LYS LYS A . n A 1 247 ALA 247 246 246 ALA ALA A . n A 1 248 GLU 248 247 247 GLU GLU A . n A 1 249 LYS 249 248 248 LYS LYS A . n A 1 250 GLU 250 249 249 GLU GLU A . n A 1 251 VAL 251 250 250 VAL VAL A . n A 1 252 THR 252 251 251 THR THR A . n A 1 253 ARG 253 252 252 ARG ARG A . n A 1 254 MET 254 253 253 MET MET A . n A 1 255 VAL 255 254 254 VAL VAL A . n A 1 256 ILE 256 255 255 ILE ILE A . n A 1 257 ILE 257 256 256 ILE ILE A . n A 1 258 MET 258 257 257 MET MET A . n A 1 259 VAL 259 258 258 VAL VAL A . n A 1 260 ILE 260 259 259 ILE ILE A . n A 1 261 ALA 261 260 260 ALA ALA A . n A 1 262 PHE 262 261 261 PHE PHE A . n A 1 263 LEU 263 262 262 LEU LEU A . n A 1 264 ILE 264 263 263 ILE ILE A . n A 1 265 CYS 265 264 264 CYS CYS A . n A 1 266 TRP 266 265 265 TRP TRP A . n A 1 267 LEU 267 266 266 LEU LEU A . n A 1 268 PRO 268 267 267 PRO PRO A . n A 1 269 TYR 269 268 268 TYR TYR A . n A 1 270 ALA 270 269 269 ALA ALA A . n A 1 271 GLY 271 270 270 GLY GLY A . n A 1 272 VAL 272 271 271 VAL VAL A . n A 1 273 ALA 273 272 272 ALA ALA A . n A 1 274 PHE 274 273 273 PHE PHE A . n A 1 275 TYR 275 274 274 TYR TYR A . n A 1 276 ILE 276 275 275 ILE ILE A . n A 1 277 PHE 277 276 276 PHE PHE A . n A 1 278 THR 278 277 277 THR THR A . n A 1 279 HIS 279 278 278 HIS HIS A . n A 1 280 GLN 280 279 279 GLN GLN A . n A 1 281 GLY 281 280 280 GLY GLY A . n A 1 282 SER 282 281 281 SER SER A . n A 1 283 ASP 283 282 282 ASP ASP A . n A 1 284 PHE 284 283 283 PHE PHE A . n A 1 285 GLY 285 284 284 GLY GLY A . n A 1 286 PRO 286 285 285 PRO PRO A . n A 1 287 ILE 287 286 286 ILE ILE A . n A 1 288 PHE 288 287 287 PHE PHE A . n A 1 289 MET 289 288 288 MET MET A . n A 1 290 THR 290 289 289 THR THR A . n A 1 291 ILE 291 290 290 ILE ILE A . n A 1 292 PRO 292 291 291 PRO PRO A . n A 1 293 ALA 293 292 292 ALA ALA A . n A 1 294 PHE 294 293 293 PHE PHE A . n A 1 295 PHE 295 294 294 PHE PHE A . n A 1 296 ALA 296 295 295 ALA ALA A . n A 1 297 LYS 297 296 296 LYS LYS A . n A 1 298 THR 298 297 297 THR THR A . n A 1 299 SER 299 298 298 SER SER A . n A 1 300 ALA 300 299 299 ALA ALA A . n A 1 301 VAL 301 300 300 VAL VAL A . n A 1 302 TYR 302 301 301 TYR TYR A . n A 1 303 ASN 303 302 302 ASN ASN A . n A 1 304 PRO 304 303 303 PRO PRO A . n A 1 305 VAL 305 304 304 VAL VAL A . n A 1 306 ILE 306 305 305 ILE ILE A . n A 1 307 TYR 307 306 306 TYR TYR A . n A 1 308 ILE 308 307 307 ILE ILE A . n A 1 309 MET 309 308 308 MET MET A . n A 1 310 MET 310 309 309 MET MET A . n A 1 311 ASN 311 310 310 ASN ASN A . n A 1 312 LYS 312 311 311 LYS LYS A . n A 1 313 GLN 313 312 312 GLN GLN A . n A 1 314 PHE 314 313 313 PHE PHE A . n A 1 315 ARG 315 314 314 ARG ARG A . n A 1 316 ASN 316 315 315 ASN ASN A . n A 1 317 CYS 317 316 316 CYS CYS A . n A 1 318 MET 318 317 317 MET MET A . n A 1 319 VAL 319 318 318 VAL VAL A . n A 1 320 THR 320 319 319 THR THR A . n A 1 321 THR 321 320 320 THR THR A . n A 1 322 LEU 322 321 321 LEU LEU A . n A 1 323 CYS 323 322 322 CYS CYS A . n A 1 324 CYS 324 323 323 CYS CYS A . n A 1 325 GLY 325 324 324 GLY GLY A . n A 1 326 LYS 326 325 325 LYS LYS A . n A 1 327 ASN 327 326 326 ASN ASN A . n A 1 328 PRO 328 327 ? ? ? A . n A 1 329 LEU 329 328 ? ? ? A . n A 1 330 GLY 330 329 ? ? ? A . n A 1 331 ASP 331 330 330 ASP ASP A . n A 1 332 ASP 332 331 331 ASP ASP A . n A 1 333 GLU 333 332 332 GLU GLU A . n A 1 334 ALA 334 333 ? ? ? A . n A 1 335 SER 335 334 ? ? ? A . n A 1 336 THR 336 335 ? ? ? A . n A 1 337 THR 337 336 ? ? ? A . n A 1 338 VAL 338 337 ? ? ? A . n A 1 339 SER 339 338 ? ? ? A . n A 1 340 LYS 340 339 ? ? ? A . n A 1 341 THR 341 340 ? ? ? A . n A 1 342 GLU 342 341 ? ? ? A . n A 1 343 THR 343 342 ? ? ? A . n A 1 344 SER 344 343 ? ? ? A . n A 1 345 GLN 345 344 ? ? ? A . n A 1 346 VAL 346 345 ? ? ? A . n A 1 347 ALA 347 346 ? ? ? A . n A 1 348 PRO 348 347 ? ? ? A . n A 1 349 ALA 349 348 ? ? ? A . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code B 2 NAG 1 1335 1335 NAG NAG A . C 2 NAG 2 1336 1336 NAG NAG A . D 3 BMA 3 1337 1337 BMA BMA A . E 2 NAG 1 1338 1338 NAG NAG A . F 2 NAG 2 1339 1339 NAG NAG A . G 4 RET 1 1332 1332 RET RET A . H 5 PLM 1 1333 1333 PLM PLM A . I 5 PLM 1 1334 1334 PLM PLM A . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 3 A ASN 2 ? ASN 'GLYCOSYLATION SITE' 2 A ASN 16 A ASN 15 ? ASN 'GLYCOSYLATION SITE' # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_defined_assembly _pdbx_struct_assembly.method_details ? _pdbx_struct_assembly.oligomeric_details monomeric _pdbx_struct_assembly.oligomeric_count 1 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G,H,I # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2006-10-17 2 'Structure model' 1 1 2008-05-01 3 'Structure model' 1 2 2011-07-13 4 'Structure model' 1 3 2017-10-18 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Version format compliance' 2 3 'Structure model' 'Non-polymer description' 3 3 'Structure model' 'Version format compliance' 4 4 'Structure model' 'Refinement description' # _pdbx_audit_revision_category.ordinal 1 _pdbx_audit_revision_category.revision_ordinal 4 _pdbx_audit_revision_category.data_content_type 'Structure model' _pdbx_audit_revision_category.category software # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal REFMAC refinement 5.2.0005 ? 1 HKL-2000 'data reduction' . ? 2 HKL-2000 'data scaling' . ? 3 MOLREP phasing . ? 4 # _pdbx_validate_close_contact.id 1 _pdbx_validate_close_contact.PDB_model_num 1 _pdbx_validate_close_contact.auth_atom_id_1 O _pdbx_validate_close_contact.auth_asym_id_1 A _pdbx_validate_close_contact.auth_comp_id_1 ASN _pdbx_validate_close_contact.auth_seq_id_1 315 _pdbx_validate_close_contact.PDB_ins_code_1 ? _pdbx_validate_close_contact.label_alt_id_1 ? _pdbx_validate_close_contact.auth_atom_id_2 OG1 _pdbx_validate_close_contact.auth_asym_id_2 A _pdbx_validate_close_contact.auth_comp_id_2 THR _pdbx_validate_close_contact.auth_seq_id_2 319 _pdbx_validate_close_contact.PDB_ins_code_2 ? _pdbx_validate_close_contact.label_alt_id_2 ? _pdbx_validate_close_contact.dist 1.98 # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 PRO A 12 ? ? -69.69 52.68 2 1 SER A 14 ? ? -59.39 107.88 3 1 ASN A 15 ? ? -68.58 30.25 4 1 ALA A 32 ? ? -169.52 -123.30 5 1 SER A 38 ? ? -68.56 7.99 6 1 VAL A 63 ? ? -44.62 -70.74 7 1 LEU A 95 ? ? -47.50 -71.58 8 1 TYR A 102 ? ? 173.60 162.30 9 1 ASN A 111 ? ? -65.36 -73.39 10 1 LEU A 112 ? ? -40.24 -73.68 11 1 LYS A 141 ? ? 28.31 60.79 12 1 SER A 144 ? ? -63.21 -179.38 13 1 ASN A 145 ? ? -43.27 104.27 14 1 SER A 176 ? ? 62.44 -178.31 15 1 GLN A 184 ? ? 65.93 -21.74 16 1 HIS A 195 ? ? 31.15 91.95 17 1 GLU A 197 ? ? -69.18 1.40 18 1 PHE A 212 ? ? -143.59 -65.80 19 1 GLN A 238 ? ? 69.43 -6.74 20 1 GLU A 239 ? ? -32.77 123.48 21 1 GLU A 249 ? ? -58.78 -8.11 22 1 HIS A 278 ? ? -104.78 55.26 23 1 GLN A 279 ? ? -57.94 98.10 24 1 ALA A 292 ? ? -73.24 -78.54 25 1 VAL A 300 ? ? -135.09 -50.50 26 1 CYS A 323 ? ? 74.59 68.22 27 1 ASP A 331 ? ? -174.37 -68.03 # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 Y 1 A ASP 330 ? CG ? A ASP 331 CG 2 1 Y 1 A ASP 330 ? OD1 ? A ASP 331 OD1 3 1 Y 1 A ASP 330 ? OD2 ? A ASP 331 OD2 4 1 Y 1 A ASP 331 ? CG ? A ASP 332 CG 5 1 Y 1 A ASP 331 ? OD1 ? A ASP 332 OD1 6 1 Y 1 A ASP 331 ? OD2 ? A ASP 332 OD2 7 1 Y 1 A GLU 332 ? CA ? A GLU 333 CA 8 1 Y 1 A GLU 332 ? C ? A GLU 333 C 9 1 Y 1 A GLU 332 ? O ? A GLU 333 O 10 1 Y 1 A GLU 332 ? CB ? A GLU 333 CB 11 1 Y 1 A GLU 332 ? CG ? A GLU 333 CG 12 1 Y 1 A GLU 332 ? CD ? A GLU 333 CD 13 1 Y 1 A GLU 332 ? OE1 ? A GLU 333 OE1 14 1 Y 1 A GLU 332 ? OE2 ? A GLU 333 OE2 15 1 N 1 A RET 1332 ? O1 ? G RET 1 O1 16 1 N 1 A PLM 1333 ? O2 ? H PLM 1 O2 17 1 N 1 A PLM 1334 ? O2 ? I PLM 1 O2 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A PRO 327 ? A PRO 328 2 1 Y 1 A LEU 328 ? A LEU 329 3 1 Y 1 A GLY 329 ? A GLY 330 4 1 Y 1 A ALA 333 ? A ALA 334 5 1 Y 1 A SER 334 ? A SER 335 6 1 Y 1 A THR 335 ? A THR 336 7 1 Y 1 A THR 336 ? A THR 337 8 1 Y 1 A VAL 337 ? A VAL 338 9 1 Y 1 A SER 338 ? A SER 339 10 1 Y 1 A LYS 339 ? A LYS 340 11 1 Y 1 A THR 340 ? A THR 341 12 1 Y 1 A GLU 341 ? A GLU 342 13 1 Y 1 A THR 342 ? A THR 343 14 1 Y 1 A SER 343 ? A SER 344 15 1 Y 1 A GLN 344 ? A GLN 345 16 1 Y 1 A VAL 345 ? A VAL 346 17 1 Y 1 A ALA 346 ? A ALA 347 18 1 Y 1 A PRO 347 ? A PRO 348 19 1 Y 1 A ALA 348 ? A ALA 349 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 BETA-D-MANNOSE BMA 4 RETINAL RET 5 'PALMITIC ACID' PLM #