data_2AEZ # _entry.id 2AEZ # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 2AEZ RCSB RCSB033814 WWPDB D_1000033814 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.details _pdbx_database_related.content_type PDB 2ADD 'Crystal structure of fructan 1-exohydrolase IIa from Cichorium intybus in complex with sucrose' unspecified PDB 2ADE 'Crystal structure of fructan 1-exohydrolase IIa from Cichorium intybus in complex with fructose' unspecified PDB 2AEY 'Crystal structure of fructan 1-exohydrolase IIa from Cichorium intybus in complex with 2,5 dideoxy-2,5-immino-D-mannitol' unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 2AEZ _pdbx_database_status.recvd_initial_deposition_date 2005-07-25 _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry ? _pdbx_database_status.status_code_cs ? _pdbx_database_status.pdb_format_compatible Y # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Verhaest, M.' 1 'Lammens, W.' 2 'Le Roy, K.' 3 'De Ranter, C.J.' 4 'Van Laere, A.' 5 'Van den Ende, W.' 6 'Rabijns, A.' 7 # _citation.id primary _citation.title ;Insights into the fine architecture of the active site of chicory fructan 1-exohydrolase: 1-kestose as substrate vs sucrose as inhibitor. ; _citation.journal_abbrev 'New Phytol' _citation.journal_volume 174 _citation.page_first 90 _citation.page_last 100 _citation.year 2007 _citation.journal_id_ASTM ? _citation.country ? _citation.journal_id_ISSN ? _citation.journal_id_CSD 0353 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 17335500 _citation.pdbx_database_id_DOI 10.1111/j.1469-8137.2007.01988.x # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Verhaest, M.' 1 primary 'Lammens, W.' 2 primary 'Le Roy, K.' 3 primary 'De Ranter, C.J.' 4 primary 'Van Laere, A.' 5 primary 'Rabijns, A.' 6 primary 'Van den Ende, W.' 7 # _cell.entry_id 2AEZ _cell.length_a 139.068 _cell.length_b 139.068 _cell.length_c 181.005 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 90.00 _cell.Z_PDB 8 _cell.pdbx_unique_axis ? _cell.length_a_esd ? _cell.length_b_esd ? _cell.length_c_esd ? _cell.angle_alpha_esd ? _cell.angle_beta_esd ? _cell.angle_gamma_esd ? # _symmetry.entry_id 2AEZ _symmetry.space_group_name_H-M 'P 41 21 2' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 92 _symmetry.space_group_name_Hall ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'fructan 1-exohydrolase IIa' 61114.980 1 3.2.1.153 E201Q ? ? 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 3 ? ? ? ? 3 non-polymer man '2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE' 221.208 1 ? ? ? ? 4 non-polymer man BETA-D-MANNOSE 180.156 2 ? ? ? ? 5 non-polymer man 'beta-D-fructofuranosyl-(2->1)-beta-D-fructofuranosyl alpha-D-glucopyranoside' 504.437 1 ? ? ? ? 6 water nat water 18.015 85 ? ? ? ? # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;QQIEQPYRTGYHFQPPSNWMNDPNGPMLYQGVYHFFYQYNPYAATFGDVIIWGHAVSYDLVNWIHLDPAIYPTQEADSKS CWSGSATILPGNIPAMLYTGSDSKSRQVQDLAWPKNLSDPFLREWVKHPKNPLITPPEGVKDDCFRDPSTAWLGPDGVWR IVVGGDRDNNGMAFLYQSTDFVNWKRYDQPLSSADATGTWQCPDFYPVPLNSTNGLDTSVYGGSVRHVMKAGFEGHDWYT IGTYSPDRENFLPQNGLSLTGSTLDLRYDYGQFYASKSFFDDAKNRRVLWAWVPETDSQADDIEKGWAGLQSFPRALWID RNGKQLIQWPVEEIEELRQNQVNLQNKNLKPGSVLEIHGIAASQADVTISFKLEGLKEAEVLDTTLVDPQALCNERGASS RGALGPFGLLAMASKDLKEQSAIFFRVFQNQLGRYSVLMCSDLSRSTVRSNIDTTSYGAFVDIDPRSEEISLRNLIDHSI IESFGAGGKTCITSRIYPKFVNNEEAHLFVFNNGTQNVKISEMSAWSMKNAKFVVDQSVKSAA ; _entity_poly.pdbx_seq_one_letter_code_can ;QQIEQPYRTGYHFQPPSNWMNDPNGPMLYQGVYHFFYQYNPYAATFGDVIIWGHAVSYDLVNWIHLDPAIYPTQEADSKS CWSGSATILPGNIPAMLYTGSDSKSRQVQDLAWPKNLSDPFLREWVKHPKNPLITPPEGVKDDCFRDPSTAWLGPDGVWR IVVGGDRDNNGMAFLYQSTDFVNWKRYDQPLSSADATGTWQCPDFYPVPLNSTNGLDTSVYGGSVRHVMKAGFEGHDWYT IGTYSPDRENFLPQNGLSLTGSTLDLRYDYGQFYASKSFFDDAKNRRVLWAWVPETDSQADDIEKGWAGLQSFPRALWID RNGKQLIQWPVEEIEELRQNQVNLQNKNLKPGSVLEIHGIAASQADVTISFKLEGLKEAEVLDTTLVDPQALCNERGASS RGALGPFGLLAMASKDLKEQSAIFFRVFQNQLGRYSVLMCSDLSRSTVRSNIDTTSYGAFVDIDPRSEEISLRNLIDHSI IESFGAGGKTCITSRIYPKFVNNEEAHLFVFNNGTQNVKISEMSAWSMKNAKFVVDQSVKSAA ; _entity_poly.pdbx_strand_id A _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 GLN n 1 2 GLN n 1 3 ILE n 1 4 GLU n 1 5 GLN n 1 6 PRO n 1 7 TYR n 1 8 ARG n 1 9 THR n 1 10 GLY n 1 11 TYR n 1 12 HIS n 1 13 PHE n 1 14 GLN n 1 15 PRO n 1 16 PRO n 1 17 SER n 1 18 ASN n 1 19 TRP n 1 20 MET n 1 21 ASN n 1 22 ASP n 1 23 PRO n 1 24 ASN n 1 25 GLY n 1 26 PRO n 1 27 MET n 1 28 LEU n 1 29 TYR n 1 30 GLN n 1 31 GLY n 1 32 VAL n 1 33 TYR n 1 34 HIS n 1 35 PHE n 1 36 PHE n 1 37 TYR n 1 38 GLN n 1 39 TYR n 1 40 ASN n 1 41 PRO n 1 42 TYR n 1 43 ALA n 1 44 ALA n 1 45 THR n 1 46 PHE n 1 47 GLY n 1 48 ASP n 1 49 VAL n 1 50 ILE n 1 51 ILE n 1 52 TRP n 1 53 GLY n 1 54 HIS n 1 55 ALA n 1 56 VAL n 1 57 SER n 1 58 TYR n 1 59 ASP n 1 60 LEU n 1 61 VAL n 1 62 ASN n 1 63 TRP n 1 64 ILE n 1 65 HIS n 1 66 LEU n 1 67 ASP n 1 68 PRO n 1 69 ALA n 1 70 ILE n 1 71 TYR n 1 72 PRO n 1 73 THR n 1 74 GLN n 1 75 GLU n 1 76 ALA n 1 77 ASP n 1 78 SER n 1 79 LYS n 1 80 SER n 1 81 CYS n 1 82 TRP n 1 83 SER n 1 84 GLY n 1 85 SER n 1 86 ALA n 1 87 THR n 1 88 ILE n 1 89 LEU n 1 90 PRO n 1 91 GLY n 1 92 ASN n 1 93 ILE n 1 94 PRO n 1 95 ALA n 1 96 MET n 1 97 LEU n 1 98 TYR n 1 99 THR n 1 100 GLY n 1 101 SER n 1 102 ASP n 1 103 SER n 1 104 LYS n 1 105 SER n 1 106 ARG n 1 107 GLN n 1 108 VAL n 1 109 GLN n 1 110 ASP n 1 111 LEU n 1 112 ALA n 1 113 TRP n 1 114 PRO n 1 115 LYS n 1 116 ASN n 1 117 LEU n 1 118 SER n 1 119 ASP n 1 120 PRO n 1 121 PHE n 1 122 LEU n 1 123 ARG n 1 124 GLU n 1 125 TRP n 1 126 VAL n 1 127 LYS n 1 128 HIS n 1 129 PRO n 1 130 LYS n 1 131 ASN n 1 132 PRO n 1 133 LEU n 1 134 ILE n 1 135 THR n 1 136 PRO n 1 137 PRO n 1 138 GLU n 1 139 GLY n 1 140 VAL n 1 141 LYS n 1 142 ASP n 1 143 ASP n 1 144 CYS n 1 145 PHE n 1 146 ARG n 1 147 ASP n 1 148 PRO n 1 149 SER n 1 150 THR n 1 151 ALA n 1 152 TRP n 1 153 LEU n 1 154 GLY n 1 155 PRO n 1 156 ASP n 1 157 GLY n 1 158 VAL n 1 159 TRP n 1 160 ARG n 1 161 ILE n 1 162 VAL n 1 163 VAL n 1 164 GLY n 1 165 GLY n 1 166 ASP n 1 167 ARG n 1 168 ASP n 1 169 ASN n 1 170 ASN n 1 171 GLY n 1 172 MET n 1 173 ALA n 1 174 PHE n 1 175 LEU n 1 176 TYR n 1 177 GLN n 1 178 SER n 1 179 THR n 1 180 ASP n 1 181 PHE n 1 182 VAL n 1 183 ASN n 1 184 TRP n 1 185 LYS n 1 186 ARG n 1 187 TYR n 1 188 ASP n 1 189 GLN n 1 190 PRO n 1 191 LEU n 1 192 SER n 1 193 SER n 1 194 ALA n 1 195 ASP n 1 196 ALA n 1 197 THR n 1 198 GLY n 1 199 THR n 1 200 TRP n 1 201 GLN n 1 202 CYS n 1 203 PRO n 1 204 ASP n 1 205 PHE n 1 206 TYR n 1 207 PRO n 1 208 VAL n 1 209 PRO n 1 210 LEU n 1 211 ASN n 1 212 SER n 1 213 THR n 1 214 ASN n 1 215 GLY n 1 216 LEU n 1 217 ASP n 1 218 THR n 1 219 SER n 1 220 VAL n 1 221 TYR n 1 222 GLY n 1 223 GLY n 1 224 SER n 1 225 VAL n 1 226 ARG n 1 227 HIS n 1 228 VAL n 1 229 MET n 1 230 LYS n 1 231 ALA n 1 232 GLY n 1 233 PHE n 1 234 GLU n 1 235 GLY n 1 236 HIS n 1 237 ASP n 1 238 TRP n 1 239 TYR n 1 240 THR n 1 241 ILE n 1 242 GLY n 1 243 THR n 1 244 TYR n 1 245 SER n 1 246 PRO n 1 247 ASP n 1 248 ARG n 1 249 GLU n 1 250 ASN n 1 251 PHE n 1 252 LEU n 1 253 PRO n 1 254 GLN n 1 255 ASN n 1 256 GLY n 1 257 LEU n 1 258 SER n 1 259 LEU n 1 260 THR n 1 261 GLY n 1 262 SER n 1 263 THR n 1 264 LEU n 1 265 ASP n 1 266 LEU n 1 267 ARG n 1 268 TYR n 1 269 ASP n 1 270 TYR n 1 271 GLY n 1 272 GLN n 1 273 PHE n 1 274 TYR n 1 275 ALA n 1 276 SER n 1 277 LYS n 1 278 SER n 1 279 PHE n 1 280 PHE n 1 281 ASP n 1 282 ASP n 1 283 ALA n 1 284 LYS n 1 285 ASN n 1 286 ARG n 1 287 ARG n 1 288 VAL n 1 289 LEU n 1 290 TRP n 1 291 ALA n 1 292 TRP n 1 293 VAL n 1 294 PRO n 1 295 GLU n 1 296 THR n 1 297 ASP n 1 298 SER n 1 299 GLN n 1 300 ALA n 1 301 ASP n 1 302 ASP n 1 303 ILE n 1 304 GLU n 1 305 LYS n 1 306 GLY n 1 307 TRP n 1 308 ALA n 1 309 GLY n 1 310 LEU n 1 311 GLN n 1 312 SER n 1 313 PHE n 1 314 PRO n 1 315 ARG n 1 316 ALA n 1 317 LEU n 1 318 TRP n 1 319 ILE n 1 320 ASP n 1 321 ARG n 1 322 ASN n 1 323 GLY n 1 324 LYS n 1 325 GLN n 1 326 LEU n 1 327 ILE n 1 328 GLN n 1 329 TRP n 1 330 PRO n 1 331 VAL n 1 332 GLU n 1 333 GLU n 1 334 ILE n 1 335 GLU n 1 336 GLU n 1 337 LEU n 1 338 ARG n 1 339 GLN n 1 340 ASN n 1 341 GLN n 1 342 VAL n 1 343 ASN n 1 344 LEU n 1 345 GLN n 1 346 ASN n 1 347 LYS n 1 348 ASN n 1 349 LEU n 1 350 LYS n 1 351 PRO n 1 352 GLY n 1 353 SER n 1 354 VAL n 1 355 LEU n 1 356 GLU n 1 357 ILE n 1 358 HIS n 1 359 GLY n 1 360 ILE n 1 361 ALA n 1 362 ALA n 1 363 SER n 1 364 GLN n 1 365 ALA n 1 366 ASP n 1 367 VAL n 1 368 THR n 1 369 ILE n 1 370 SER n 1 371 PHE n 1 372 LYS n 1 373 LEU n 1 374 GLU n 1 375 GLY n 1 376 LEU n 1 377 LYS n 1 378 GLU n 1 379 ALA n 1 380 GLU n 1 381 VAL n 1 382 LEU n 1 383 ASP n 1 384 THR n 1 385 THR n 1 386 LEU n 1 387 VAL n 1 388 ASP n 1 389 PRO n 1 390 GLN n 1 391 ALA n 1 392 LEU n 1 393 CYS n 1 394 ASN n 1 395 GLU n 1 396 ARG n 1 397 GLY n 1 398 ALA n 1 399 SER n 1 400 SER n 1 401 ARG n 1 402 GLY n 1 403 ALA n 1 404 LEU n 1 405 GLY n 1 406 PRO n 1 407 PHE n 1 408 GLY n 1 409 LEU n 1 410 LEU n 1 411 ALA n 1 412 MET n 1 413 ALA n 1 414 SER n 1 415 LYS n 1 416 ASP n 1 417 LEU n 1 418 LYS n 1 419 GLU n 1 420 GLN n 1 421 SER n 1 422 ALA n 1 423 ILE n 1 424 PHE n 1 425 PHE n 1 426 ARG n 1 427 VAL n 1 428 PHE n 1 429 GLN n 1 430 ASN n 1 431 GLN n 1 432 LEU n 1 433 GLY n 1 434 ARG n 1 435 TYR n 1 436 SER n 1 437 VAL n 1 438 LEU n 1 439 MET n 1 440 CYS n 1 441 SER n 1 442 ASP n 1 443 LEU n 1 444 SER n 1 445 ARG n 1 446 SER n 1 447 THR n 1 448 VAL n 1 449 ARG n 1 450 SER n 1 451 ASN n 1 452 ILE n 1 453 ASP n 1 454 THR n 1 455 THR n 1 456 SER n 1 457 TYR n 1 458 GLY n 1 459 ALA n 1 460 PHE n 1 461 VAL n 1 462 ASP n 1 463 ILE n 1 464 ASP n 1 465 PRO n 1 466 ARG n 1 467 SER n 1 468 GLU n 1 469 GLU n 1 470 ILE n 1 471 SER n 1 472 LEU n 1 473 ARG n 1 474 ASN n 1 475 LEU n 1 476 ILE n 1 477 ASP n 1 478 HIS n 1 479 SER n 1 480 ILE n 1 481 ILE n 1 482 GLU n 1 483 SER n 1 484 PHE n 1 485 GLY n 1 486 ALA n 1 487 GLY n 1 488 GLY n 1 489 LYS n 1 490 THR n 1 491 CYS n 1 492 ILE n 1 493 THR n 1 494 SER n 1 495 ARG n 1 496 ILE n 1 497 TYR n 1 498 PRO n 1 499 LYS n 1 500 PHE n 1 501 VAL n 1 502 ASN n 1 503 ASN n 1 504 GLU n 1 505 GLU n 1 506 ALA n 1 507 HIS n 1 508 LEU n 1 509 PHE n 1 510 VAL n 1 511 PHE n 1 512 ASN n 1 513 ASN n 1 514 GLY n 1 515 THR n 1 516 GLN n 1 517 ASN n 1 518 VAL n 1 519 LYS n 1 520 ILE n 1 521 SER n 1 522 GLU n 1 523 MET n 1 524 SER n 1 525 ALA n 1 526 TRP n 1 527 SER n 1 528 MET n 1 529 LYS n 1 530 ASN n 1 531 ALA n 1 532 LYS n 1 533 PHE n 1 534 VAL n 1 535 VAL n 1 536 ASP n 1 537 GLN n 1 538 SER n 1 539 VAL n 1 540 LYS n 1 541 SER n 1 542 ALA n 1 543 ALA n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name chicory _entity_src_gen.gene_src_genus Cichorium _entity_src_gen.pdbx_gene_src_gene '1-FEH IIa' _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Cichorium intybus' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 13427 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'Pichia pastoris' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 4922 _entity_src_gen.host_org_genus Pichia _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain ? _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type ? _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name ? _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code Q93X60_CICIN _struct_ref.pdbx_db_accession Q93X60 _struct_ref.entity_id 1 _struct_ref.pdbx_align_begin 39 _struct_ref.pdbx_seq_one_letter_code ? _struct_ref.pdbx_db_isoform ? # _struct_ref_seq.align_id 1 _struct_ref_seq.ref_id 1 _struct_ref_seq.pdbx_PDB_id_code 2AEZ _struct_ref_seq.pdbx_strand_id A _struct_ref_seq.seq_align_beg 1 _struct_ref_seq.pdbx_seq_align_beg_ins_code ? _struct_ref_seq.seq_align_end 543 _struct_ref_seq.pdbx_seq_align_end_ins_code ? _struct_ref_seq.pdbx_db_accession Q93X60 _struct_ref_seq.db_align_beg 39 _struct_ref_seq.pdbx_db_align_beg_ins_code ? _struct_ref_seq.db_align_end 581 _struct_ref_seq.pdbx_db_align_end_ins_code ? _struct_ref_seq.pdbx_auth_seq_align_beg 1 _struct_ref_seq.pdbx_auth_seq_align_end 543 # _struct_ref_seq_dif.align_id 1 _struct_ref_seq_dif.pdbx_pdb_id_code 2AEZ _struct_ref_seq_dif.mon_id GLN _struct_ref_seq_dif.pdbx_pdb_strand_id A _struct_ref_seq_dif.seq_num 201 _struct_ref_seq_dif.pdbx_pdb_ins_code ? _struct_ref_seq_dif.pdbx_seq_db_name UNP _struct_ref_seq_dif.pdbx_seq_db_accession_code Q93X60 _struct_ref_seq_dif.db_mon_id GLU _struct_ref_seq_dif.pdbx_seq_db_seq_num 239 _struct_ref_seq_dif.details ENGINEERED _struct_ref_seq_dif.pdbx_auth_seq_num 201 _struct_ref_seq_dif.pdbx_ordinal 1 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 BMA D-saccharide . BETA-D-MANNOSE ? 'C6 H12 O6' 180.156 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 DQR D-saccharide . 'beta-D-fructofuranosyl-(2->1)-beta-D-fructofuranosyl alpha-D-glucopyranoside' 1-KESTOSE 'C18 H32 O16' 504.437 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 NDG D-saccharide . '2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE' ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 2AEZ _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 7.2 _exptl_crystal.density_percent_sol 82 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.temp 277 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 7.0 _exptl_crystal_grow.pdbx_details 'sodium potassium phosphate, potassium phosphate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K' _exptl_crystal_grow.pdbx_pH_range . # _diffrn.id 1 _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type MARRESEARCH _diffrn_detector.pdbx_collection_date 2005-05-02 _diffrn_detector.details 'bent mirror' # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator 'triangular monochromator' _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.8424 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'EMBL/DESY, HAMBURG BEAMLINE BW7B' _diffrn_source.pdbx_synchrotron_site 'EMBL/DESY, Hamburg' _diffrn_source.pdbx_synchrotron_beamline BW7B _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list 0.8424 # _reflns.entry_id 2AEZ _reflns.observed_criterion_sigma_I 2.0 _reflns.observed_criterion_sigma_F 1.41 _reflns.d_resolution_low 40 _reflns.d_resolution_high 3.05 _reflns.number_obs 27790 _reflns.number_all 34494 _reflns.percent_possible_obs 80.4 _reflns.pdbx_Rmerge_I_obs 0.11 _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI ? _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy 5.6 _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # _reflns_shell.d_res_high 3.05 _reflns_shell.d_res_low 3.10 _reflns_shell.percent_possible_all 99.6 _reflns_shell.Rmerge_I_obs 0.498 _reflns_shell.pdbx_Rsym_value ? _reflns_shell.meanI_over_sigI_obs ? _reflns_shell.pdbx_redundancy ? _reflns_shell.percent_possible_obs ? _reflns_shell.number_unique_all ? _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_unique_obs ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 # _refine.entry_id 2AEZ _refine.ls_number_reflns_obs 59934 _refine.ls_number_reflns_all 59940 _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F 0.0 _refine.pdbx_data_cutoff_high_absF 174791.28 _refine.pdbx_data_cutoff_low_absF 0.000000 _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 29.44 _refine.ls_d_res_high 3.05 _refine.ls_percent_reflns_obs 92.9 _refine.ls_R_factor_obs 0.207 _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work 0.207 _refine.ls_R_factor_R_free 0.242 _refine.ls_R_factor_R_free_error 0.003 _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 9.8 _refine.ls_number_reflns_R_free 5889 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc ? _refine.correlation_coeff_Fo_to_Fc_free ? _refine.B_iso_mean 45.4 _refine.aniso_B[1][1] 10.42 _refine.aniso_B[2][2] 10.42 _refine.aniso_B[3][3] -20.84 _refine.aniso_B[1][2] 0.00 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_details 'FLAT MODEL' _refine.solvent_model_param_ksol 0.46991 _refine.solvent_model_param_bsol 58.4799 _refine.pdbx_solvent_vdw_probe_radii ? _refine.pdbx_solvent_ion_probe_radii ? _refine.pdbx_solvent_shrinkage_radii ? _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details 'FRIEDEL PAIRS WERE USED IN REFINEMENT.' _refine.pdbx_starting_model 'PDB ENTRY 1ST8' _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model RESTRAINED _refine.pdbx_stereochemistry_target_values 'Engh & Huber' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R_Free ? _refine.overall_SU_ML ? _refine.overall_SU_B ? _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_overall_phase_error ? _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_diffrn_id 1 _refine.pdbx_overall_ESU_R ? _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_analyze.entry_id 2AEZ _refine_analyze.Luzzati_coordinate_error_obs 0.33 _refine_analyze.Luzzati_sigma_a_obs 0.56 _refine_analyze.Luzzati_d_res_low_obs 5.00 _refine_analyze.Luzzati_coordinate_error_free 0.38 _refine_analyze.Luzzati_sigma_a_free 0.60 _refine_analyze.Luzzati_d_res_low_free ? _refine_analyze.number_disordered_residues ? _refine_analyze.occupancy_sum_hydrogen ? _refine_analyze.occupancy_sum_non_hydrogen ? _refine_analyze.pdbx_Luzzati_d_res_high_obs ? _refine_analyze.pdbx_refine_id 'X-RAY DIFFRACTION' # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 4265 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 112 _refine_hist.number_atoms_solvent 85 _refine_hist.number_atoms_total 4462 _refine_hist.d_res_high 3.05 _refine_hist.d_res_low 29.44 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function c_bond_d 0.007 ? ? ? 'X-RAY DIFFRACTION' ? c_bond_d_na ? ? ? ? 'X-RAY DIFFRACTION' ? c_bond_d_prot ? ? ? ? 'X-RAY DIFFRACTION' ? c_angle_d ? ? ? ? 'X-RAY DIFFRACTION' ? c_angle_d_na ? ? ? ? 'X-RAY DIFFRACTION' ? c_angle_d_prot ? ? ? ? 'X-RAY DIFFRACTION' ? c_angle_deg 1.4 ? ? ? 'X-RAY DIFFRACTION' ? c_angle_deg_na ? ? ? ? 'X-RAY DIFFRACTION' ? c_angle_deg_prot ? ? ? ? 'X-RAY DIFFRACTION' ? c_dihedral_angle_d 25.5 ? ? ? 'X-RAY DIFFRACTION' ? c_dihedral_angle_d_na ? ? ? ? 'X-RAY DIFFRACTION' ? c_dihedral_angle_d_prot ? ? ? ? 'X-RAY DIFFRACTION' ? c_improper_angle_d 0.86 ? ? ? 'X-RAY DIFFRACTION' ? c_improper_angle_d_na ? ? ? ? 'X-RAY DIFFRACTION' ? c_improper_angle_d_prot ? ? ? ? 'X-RAY DIFFRACTION' ? c_mcbond_it 1.22 1.50 ? ? 'X-RAY DIFFRACTION' ? c_mcangle_it 2.14 2.00 ? ? 'X-RAY DIFFRACTION' ? c_scbond_it 1.79 2.00 ? ? 'X-RAY DIFFRACTION' ? c_scangle_it 2.95 2.50 ? ? 'X-RAY DIFFRACTION' ? # _refine_ls_shell.pdbx_total_number_of_bins_used 6 _refine_ls_shell.d_res_high 3.05 _refine_ls_shell.d_res_low 3.24 _refine_ls_shell.number_reflns_R_work 8232 _refine_ls_shell.R_factor_R_work 0.309 _refine_ls_shell.percent_reflns_obs 84.5 _refine_ls_shell.R_factor_R_free 0.332 _refine_ls_shell.R_factor_R_free_error 0.011 _refine_ls_shell.percent_reflns_R_free 9.3 _refine_ls_shell.number_reflns_R_free 848 _refine_ls_shell.number_reflns_all ? _refine_ls_shell.R_factor_all ? _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' # loop_ _pdbx_xplor_file.serial_no _pdbx_xplor_file.param_file _pdbx_xplor_file.topol_file _pdbx_xplor_file.pdbx_refine_id 1 protein_rep.param protein.top 'X-RAY DIFFRACTION' 2 water_rep.param water.top 'X-RAY DIFFRACTION' 3 carbohydrate.param carbohydrate.top 'X-RAY DIFFRACTION' 4 1kes.par 1kes.top 'X-RAY DIFFRACTION' # _struct.entry_id 2AEZ _struct.title 'Crystal structure of fructan 1-exohydrolase IIa (E201Q) from Cichorium intybus in complex with 1-kestose' _struct.pdbx_descriptor 'fructan 1-exohydrolase IIa (E.C.3.2.1.153)' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 2AEZ _struct_keywords.pdbx_keywords HYDROLASE _struct_keywords.text 'five fold beta propeller, HYDROLASE' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 3 ? D N N 2 ? E N N 2 ? F N N 4 ? G N N 4 ? H N N 5 ? I N N 6 ? # _struct_biol.id 1 _struct_biol.details ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 GLN A 74 ? SER A 78 ? GLN A 74 SER A 78 5 ? 5 HELX_P HELX_P2 2 SER A 298 ? GLY A 306 ? SER A 298 GLY A 306 1 ? 9 HELX_P HELX_P3 3 GLU A 332 ? GLU A 336 ? GLU A 332 GLU A 336 5 ? 5 HELX_P HELX_P4 4 GLY A 375 ? ALA A 379 ? GLY A 375 ALA A 379 5 ? 5 HELX_P HELX_P5 5 ASP A 388 ? ARG A 396 ? ASP A 388 ARG A 396 1 ? 9 HELX_P HELX_P6 6 LEU A 443 ? SER A 446 ? LEU A 443 SER A 446 5 ? 4 HELX_P HELX_P7 7 GLY A 487 ? LYS A 489 ? GLY A 487 LYS A 489 5 ? 3 HELX_P HELX_P8 8 LYS A 499 ? ASN A 503 ? LYS A 499 ASN A 503 5 ? 5 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 393 SG ? ? ? 1_555 A CYS 440 SG ? ? A CYS 393 A CYS 440 1_555 ? ? ? ? ? ? ? 2.037 ? covale1 covale ? ? A ASN 116 ND2 ? ? ? 1_555 D NAG . C1 ? ? A ASN 116 A NAG 680 1_555 ? ? ? ? ? ? ? 1.460 ? covale2 covale ? ? B NAG . O4 ? ? ? 1_555 C NDG . C1 ? ? A NAG 650 A NDG 660 1_555 ? ? ? ? ? ? ? 1.389 ? covale3 covale ? ? D NAG . O4 ? ? ? 1_555 E NAG . C1 ? ? A NAG 680 A NAG 690 1_555 ? ? ? ? ? ? ? 1.400 ? covale4 covale ? ? E NAG . O4 ? ? ? 1_555 F BMA . C1 ? ? A NAG 690 A BMA 700 1_555 ? ? ? ? ? ? ? 1.393 ? covale5 covale ? ? F BMA . O3 ? ? ? 1_555 G BMA . C1 ? ? A BMA 700 A BMA 710 1_555 ? ? ? ? ? ? ? 1.407 ? covale6 covale ? ? A ASN 513 ND2 ? ? ? 1_555 B NAG . C1 ? ? A ASN 513 A NAG 650 1_555 ? ? ? ? ? ? ? 1.449 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 ASN 131 A . ? ASN 131 A PRO 132 A ? PRO 132 A 1 0.17 2 GLY 405 A . ? GLY 405 A PRO 406 A ? PRO 406 A 1 -0.25 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 6 ? B ? 4 ? C ? 4 ? D ? 4 ? E ? 4 ? F ? 4 ? G ? 3 ? H ? 4 ? I ? 6 ? J ? 5 ? K ? 6 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? parallel A 2 3 ? anti-parallel A 3 4 ? anti-parallel A 4 5 ? anti-parallel A 5 6 ? parallel B 1 2 ? anti-parallel B 2 3 ? anti-parallel B 3 4 ? anti-parallel C 1 2 ? anti-parallel C 2 3 ? anti-parallel C 3 4 ? anti-parallel D 1 2 ? anti-parallel D 2 3 ? anti-parallel D 3 4 ? anti-parallel E 1 2 ? anti-parallel E 2 3 ? anti-parallel E 3 4 ? anti-parallel F 1 2 ? anti-parallel F 2 3 ? anti-parallel F 3 4 ? anti-parallel G 1 2 ? anti-parallel G 2 3 ? anti-parallel H 1 2 ? anti-parallel H 2 3 ? anti-parallel H 3 4 ? anti-parallel I 1 2 ? anti-parallel I 2 3 ? anti-parallel I 3 4 ? anti-parallel I 4 5 ? anti-parallel I 5 6 ? anti-parallel J 1 2 ? anti-parallel J 2 3 ? anti-parallel J 3 4 ? anti-parallel J 4 5 ? parallel K 1 2 ? anti-parallel K 2 3 ? anti-parallel K 3 4 ? anti-parallel K 4 5 ? anti-parallel K 5 6 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 TRP A 307 ? ALA A 308 ? TRP A 307 ALA A 308 A 2 ASN A 18 ? TYR A 29 ? ASN A 18 TYR A 29 A 3 VAL A 32 ? ASN A 40 ? VAL A 32 ASN A 40 A 4 ILE A 51 ? SER A 57 ? ILE A 51 SER A 57 A 5 TRP A 63 ? LEU A 66 ? TRP A 63 LEU A 66 A 6 PHE A 533 ? VAL A 535 ? PHE A 533 VAL A 535 B 1 SER A 80 ? LEU A 89 ? SER A 80 LEU A 89 B 2 ILE A 93 ? SER A 101 ? ILE A 93 SER A 101 B 3 GLN A 107 ? PRO A 114 ? GLN A 107 PRO A 114 B 4 TRP A 125 ? LYS A 127 ? TRP A 125 LYS A 127 C 1 PHE A 145 ? ARG A 146 ? PHE A 145 ARG A 146 C 2 TRP A 159 ? ARG A 167 ? TRP A 159 ARG A 167 C 3 ASN A 170 ? SER A 178 ? ASN A 170 SER A 178 C 4 LYS A 185 ? ARG A 186 ? LYS A 185 ARG A 186 D 1 TRP A 152 ? LEU A 153 ? TRP A 152 LEU A 153 D 2 TRP A 159 ? ARG A 167 ? TRP A 159 ARG A 167 D 3 ASN A 170 ? SER A 178 ? ASN A 170 SER A 178 D 4 SER A 192 ? SER A 193 ? SER A 192 SER A 193 E 1 GLN A 201 ? PRO A 209 ? GLN A 201 PRO A 209 E 2 VAL A 225 ? PHE A 233 ? VAL A 225 PHE A 233 E 3 HIS A 236 ? SER A 245 ? HIS A 236 SER A 245 E 4 ASN A 250 ? PRO A 253 ? ASN A 250 PRO A 253 F 1 GLN A 201 ? PRO A 209 ? GLN A 201 PRO A 209 F 2 VAL A 225 ? PHE A 233 ? VAL A 225 PHE A 233 F 3 HIS A 236 ? SER A 245 ? HIS A 236 SER A 245 F 4 LEU A 266 ? ARG A 267 ? LEU A 266 ARG A 267 G 1 TYR A 274 ? ASP A 281 ? TYR A 274 ASP A 281 G 2 ARG A 286 ? VAL A 293 ? ARG A 286 VAL A 293 G 3 LEU A 310 ? GLN A 311 ? LEU A 310 GLN A 311 H 1 TYR A 274 ? ASP A 281 ? TYR A 274 ASP A 281 H 2 ARG A 286 ? VAL A 293 ? ARG A 286 VAL A 293 H 3 ARG A 315 ? ILE A 319 ? ARG A 315 ILE A 319 H 4 LEU A 326 ? PRO A 330 ? LEU A 326 PRO A 330 I 1 ARG A 338 ? LEU A 349 ? ARG A 338 LEU A 349 I 2 VAL A 518 ? MET A 528 ? VAL A 518 MET A 528 I 3 GLN A 364 ? LEU A 373 ? GLN A 364 LEU A 373 I 4 ILE A 470 ? ASP A 477 ? ILE A 470 ASP A 477 I 5 ILE A 480 ? GLY A 485 ? ILE A 480 GLY A 485 I 6 THR A 490 ? ARG A 495 ? THR A 490 ARG A 495 J 1 SER A 353 ? ILE A 357 ? SER A 353 ILE A 357 J 2 HIS A 507 ? ASN A 512 ? HIS A 507 ASN A 512 J 3 LEU A 404 ? ALA A 413 ? LEU A 404 ALA A 413 J 4 SER A 421 ? GLN A 429 ? SER A 421 GLN A 429 J 5 GLU A 380 ? VAL A 381 ? GLU A 380 VAL A 381 K 1 SER A 353 ? ILE A 357 ? SER A 353 ILE A 357 K 2 HIS A 507 ? ASN A 512 ? HIS A 507 ASN A 512 K 3 LEU A 404 ? ALA A 413 ? LEU A 404 ALA A 413 K 4 SER A 421 ? GLN A 429 ? SER A 421 GLN A 429 K 5 TYR A 435 ? ASP A 442 ? TYR A 435 ASP A 442 K 6 TYR A 457 ? VAL A 461 ? TYR A 457 VAL A 461 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 O ALA A 308 ? O ALA A 308 N ASN A 18 ? N ASN A 18 A 2 3 N MET A 27 ? N MET A 27 O HIS A 34 ? O HIS A 34 A 3 4 N TYR A 33 ? N TYR A 33 O SER A 57 ? O SER A 57 A 4 5 N VAL A 56 ? N VAL A 56 O ILE A 64 ? O ILE A 64 A 5 6 N HIS A 65 ? N HIS A 65 O VAL A 534 ? O VAL A 534 B 1 2 N THR A 87 ? N THR A 87 O ALA A 95 ? O ALA A 95 B 2 3 N MET A 96 ? N MET A 96 O ALA A 112 ? O ALA A 112 B 3 4 N TRP A 113 ? N TRP A 113 O VAL A 126 ? O VAL A 126 C 1 2 N ARG A 146 ? N ARG A 146 O GLY A 164 ? O GLY A 164 C 2 3 N ILE A 161 ? N ILE A 161 O TYR A 176 ? O TYR A 176 C 3 4 N GLN A 177 ? N GLN A 177 O LYS A 185 ? O LYS A 185 D 1 2 N TRP A 152 ? N TRP A 152 O ARG A 160 ? O ARG A 160 D 2 3 N ILE A 161 ? N ILE A 161 O TYR A 176 ? O TYR A 176 D 3 4 N ALA A 173 ? N ALA A 173 O SER A 192 ? O SER A 192 E 1 2 N ASP A 204 ? N ASP A 204 O LYS A 230 ? O LYS A 230 E 2 3 N HIS A 227 ? N HIS A 227 O GLY A 242 ? O GLY A 242 E 3 4 N THR A 243 ? N THR A 243 O LEU A 252 ? O LEU A 252 F 1 2 N ASP A 204 ? N ASP A 204 O LYS A 230 ? O LYS A 230 F 2 3 N HIS A 227 ? N HIS A 227 O GLY A 242 ? O GLY A 242 F 3 4 N TYR A 239 ? N TYR A 239 O LEU A 266 ? O LEU A 266 G 1 2 N ASP A 281 ? N ASP A 281 O ARG A 286 ? O ARG A 286 G 2 3 N VAL A 293 ? N VAL A 293 O LEU A 310 ? O LEU A 310 H 1 2 N ASP A 281 ? N ASP A 281 O ARG A 286 ? O ARG A 286 H 2 3 N LEU A 289 ? N LEU A 289 O ARG A 315 ? O ARG A 315 H 3 4 N TRP A 318 ? N TRP A 318 O ILE A 327 ? O ILE A 327 I 1 2 N LYS A 347 ? N LYS A 347 O ILE A 520 ? O ILE A 520 I 2 3 O LYS A 519 ? O LYS A 519 N LYS A 372 ? N LYS A 372 I 3 4 N ALA A 365 ? N ALA A 365 O ILE A 476 ? O ILE A 476 I 4 5 N ARG A 473 ? N ARG A 473 O PHE A 484 ? O PHE A 484 I 5 6 N GLY A 485 ? N GLY A 485 O THR A 490 ? O THR A 490 J 1 2 N LEU A 355 ? N LEU A 355 O VAL A 510 ? O VAL A 510 J 2 3 O PHE A 509 ? O PHE A 509 N LEU A 410 ? N LEU A 410 J 3 4 N LEU A 409 ? N LEU A 409 O ILE A 423 ? O ILE A 423 J 4 5 O GLN A 429 ? O GLN A 429 N GLU A 380 ? N GLU A 380 K 1 2 N LEU A 355 ? N LEU A 355 O VAL A 510 ? O VAL A 510 K 2 3 O PHE A 509 ? O PHE A 509 N LEU A 410 ? N LEU A 410 K 3 4 N LEU A 409 ? N LEU A 409 O ILE A 423 ? O ILE A 423 K 4 5 N PHE A 424 ? N PHE A 424 O CYS A 440 ? O CYS A 440 K 5 6 N VAL A 437 ? N VAL A 437 O VAL A 461 ? O VAL A 461 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE NAG A 650' AC2 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE NDG A 660' AC3 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE NAG A 680' AC4 Software ? ? ? ? 7 'BINDING SITE FOR RESIDUE NAG A 690' AC5 Software ? ? ? ? 7 'BINDING SITE FOR RESIDUE BMA A 700' AC6 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE BMA A 710' AC7 Software ? ? ? ? 11 'BINDING SITE FOR RESIDUE DQR A 801' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 6 ALA A 398 ? ALA A 398 . ? 1_555 ? 2 AC1 6 SER A 399 ? SER A 399 . ? 1_555 ? 3 AC1 6 GLN A 420 ? GLN A 420 . ? 1_555 ? 4 AC1 6 ARG A 445 ? ARG A 445 . ? 1_555 ? 5 AC1 6 ASN A 513 ? ASN A 513 . ? 1_555 ? 6 AC1 6 NDG C . ? NDG A 660 . ? 1_555 ? 7 AC2 3 SER A 399 ? SER A 399 . ? 1_555 ? 8 AC2 3 ARG A 445 ? ARG A 445 . ? 1_555 ? 9 AC2 3 NAG B . ? NAG A 650 . ? 1_555 ? 10 AC3 5 ASN A 116 ? ASN A 116 . ? 1_555 ? 11 AC3 5 ASP A 119 ? ASP A 119 . ? 1_555 ? 12 AC3 5 GLU A 124 ? GLU A 124 . ? 1_555 ? 13 AC3 5 GLU A 234 ? GLU A 234 . ? 4_454 ? 14 AC3 5 NAG E . ? NAG A 690 . ? 1_555 ? 15 AC4 7 GLU A 124 ? GLU A 124 . ? 1_555 ? 16 AC4 7 ASN A 169 ? ASN A 169 . ? 4_454 ? 17 AC4 7 ALA A 196 ? ALA A 196 . ? 4_454 ? 18 AC4 7 GLY A 198 ? GLY A 198 . ? 4_454 ? 19 AC4 7 GLU A 234 ? GLU A 234 . ? 4_454 ? 20 AC4 7 NAG D . ? NAG A 680 . ? 1_555 ? 21 AC4 7 BMA F . ? BMA A 700 . ? 1_555 ? 22 AC5 7 CYS A 144 ? CYS A 144 . ? 4_454 ? 23 AC5 7 ASP A 166 ? ASP A 166 . ? 4_454 ? 24 AC5 7 ASN A 169 ? ASN A 169 . ? 4_454 ? 25 AC5 7 GLY A 198 ? GLY A 198 . ? 4_454 ? 26 AC5 7 THR A 199 ? THR A 199 . ? 4_454 ? 27 AC5 7 NAG E . ? NAG A 690 . ? 1_555 ? 28 AC5 7 BMA G . ? BMA A 710 . ? 1_555 ? 29 AC6 5 ASP A 143 ? ASP A 143 . ? 4_454 ? 30 AC6 5 ARG A 146 ? ARG A 146 . ? 4_454 ? 31 AC6 5 THR A 199 ? THR A 199 . ? 4_454 ? 32 AC6 5 BMA F . ? BMA A 700 . ? 1_555 ? 33 AC6 5 DQR H . ? DQR A 801 . ? 4_454 ? 34 AC7 11 ASN A 21 ? ASN A 21 . ? 1_555 ? 35 AC7 11 ASP A 22 ? ASP A 22 . ? 1_555 ? 36 AC7 11 GLN A 38 ? GLN A 38 . ? 1_555 ? 37 AC7 11 PHE A 46 ? PHE A 46 . ? 1_555 ? 38 AC7 11 TRP A 82 ? TRP A 82 . ? 1_555 ? 39 AC7 11 SER A 83 ? SER A 83 . ? 1_555 ? 40 AC7 11 GLN A 107 ? GLN A 107 . ? 1_555 ? 41 AC7 11 ARG A 146 ? ARG A 146 . ? 1_555 ? 42 AC7 11 ASP A 147 ? ASP A 147 . ? 1_555 ? 43 AC7 11 GLN A 201 ? GLN A 201 . ? 1_555 ? 44 AC7 11 BMA G . ? BMA A 710 . ? 3_555 ? # _database_PDB_matrix.entry_id 2AEZ _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 2AEZ _atom_sites.fract_transf_matrix[1][1] 0.007191 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.007191 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.005525 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . ILE A 1 3 ? 39.684 64.466 -13.193 1.00 80.56 ? 3 ILE A N 1 ATOM 2 C CA . ILE A 1 3 ? 38.429 63.769 -12.780 1.00 79.95 ? 3 ILE A CA 1 ATOM 3 C C . ILE A 1 3 ? 37.226 64.699 -12.917 1.00 79.36 ? 3 ILE A C 1 ATOM 4 O O . ILE A 1 3 ? 36.797 65.319 -11.942 1.00 79.84 ? 3 ILE A O 1 ATOM 5 C CB . ILE A 1 3 ? 38.532 63.298 -11.321 1.00 79.92 ? 3 ILE A CB 1 ATOM 6 C CG1 . ILE A 1 3 ? 39.787 62.437 -11.154 1.00 79.94 ? 3 ILE A CG1 1 ATOM 7 C CG2 . ILE A 1 3 ? 37.275 62.530 -10.932 1.00 80.19 ? 3 ILE A CG2 1 ATOM 8 C CD1 . ILE A 1 3 ? 40.028 61.939 -9.750 1.00 79.32 ? 3 ILE A CD1 1 ATOM 9 N N . GLU A 1 4 ? 36.686 64.791 -14.129 1.00 78.15 ? 4 GLU A N 1 ATOM 10 C CA . GLU A 1 4 ? 35.541 65.659 -14.406 1.00 77.45 ? 4 GLU A CA 1 ATOM 11 C C . GLU A 1 4 ? 34.252 65.132 -13.766 1.00 75.14 ? 4 GLU A C 1 ATOM 12 O O . GLU A 1 4 ? 34.022 63.921 -13.742 1.00 75.76 ? 4 GLU A O 1 ATOM 13 C CB . GLU A 1 4 ? 35.352 65.790 -15.920 1.00 79.77 ? 4 GLU A CB 1 ATOM 14 C CG . GLU A 1 4 ? 34.169 66.650 -16.334 1.00 84.21 ? 4 GLU A CG 1 ATOM 15 C CD . GLU A 1 4 ? 33.884 66.573 -17.824 1.00 87.44 ? 4 GLU A CD 1 ATOM 16 O OE1 . GLU A 1 4 ? 33.742 65.441 -18.342 1.00 88.81 ? 4 GLU A OE1 1 ATOM 17 O OE2 . GLU A 1 4 ? 33.791 67.640 -18.476 1.00 89.39 ? 4 GLU A OE2 1 ATOM 18 N N . GLN A 1 5 ? 33.416 66.038 -13.254 1.00 70.87 ? 5 GLN A N 1 ATOM 19 C CA . GLN A 1 5 ? 32.155 65.648 -12.618 1.00 66.32 ? 5 GLN A CA 1 ATOM 20 C C . GLN A 1 5 ? 32.391 64.543 -11.595 1.00 63.08 ? 5 GLN A C 1 ATOM 21 O O . GLN A 1 5 ? 31.866 63.440 -11.735 1.00 63.34 ? 5 GLN A O 1 ATOM 22 C CB . GLN A 1 5 ? 31.169 65.151 -13.675 1.00 66.02 ? 5 GLN A CB 1 ATOM 23 C CG . GLN A 1 5 ? 30.615 66.241 -14.555 1.00 66.70 ? 5 GLN A CG 1 ATOM 24 C CD . GLN A 1 5 ? 29.622 67.126 -13.823 1.00 67.61 ? 5 GLN A CD 1 ATOM 25 O OE1 . GLN A 1 5 ? 29.884 67.590 -12.713 1.00 66.92 ? 5 GLN A OE1 1 ATOM 26 N NE2 . GLN A 1 5 ? 28.474 67.369 -14.449 1.00 69.18 ? 5 GLN A NE2 1 ATOM 27 N N . PRO A 1 6 ? 33.177 64.830 -10.546 1.00 59.53 ? 6 PRO A N 1 ATOM 28 C CA . PRO A 1 6 ? 33.491 63.855 -9.498 1.00 56.78 ? 6 PRO A CA 1 ATOM 29 C C . PRO A 1 6 ? 32.375 63.529 -8.508 1.00 54.47 ? 6 PRO A C 1 ATOM 30 O O . PRO A 1 6 ? 32.569 62.719 -7.599 1.00 53.89 ? 6 PRO A O 1 ATOM 31 C CB . PRO A 1 6 ? 34.704 64.478 -8.820 1.00 57.49 ? 6 PRO A CB 1 ATOM 32 C CG . PRO A 1 6 ? 34.393 65.933 -8.894 1.00 57.87 ? 6 PRO A CG 1 ATOM 33 C CD . PRO A 1 6 ? 33.880 66.103 -10.305 1.00 58.65 ? 6 PRO A CD 1 ATOM 34 N N . TYR A 1 7 ? 31.209 64.144 -8.680 1.00 51.48 ? 7 TYR A N 1 ATOM 35 C CA . TYR A 1 7 ? 30.102 63.880 -7.772 1.00 48.19 ? 7 TYR A CA 1 ATOM 36 C C . TYR A 1 7 ? 28.914 63.187 -8.429 1.00 47.41 ? 7 TYR A C 1 ATOM 37 O O . TYR A 1 7 ? 27.965 62.817 -7.741 1.00 46.91 ? 7 TYR A O 1 ATOM 38 C CB . TYR A 1 7 ? 29.651 65.173 -7.097 1.00 46.43 ? 7 TYR A CB 1 ATOM 39 C CG . TYR A 1 7 ? 30.740 65.812 -6.269 1.00 45.91 ? 7 TYR A CG 1 ATOM 40 C CD1 . TYR A 1 7 ? 31.203 65.213 -5.100 1.00 46.31 ? 7 TYR A CD1 1 ATOM 41 C CD2 . TYR A 1 7 ? 31.339 66.997 -6.674 1.00 46.50 ? 7 TYR A CD2 1 ATOM 42 C CE1 . TYR A 1 7 ? 32.248 65.784 -4.352 1.00 46.12 ? 7 TYR A CE1 1 ATOM 43 C CE2 . TYR A 1 7 ? 32.379 67.574 -5.940 1.00 46.09 ? 7 TYR A CE2 1 ATOM 44 C CZ . TYR A 1 7 ? 32.831 66.965 -4.784 1.00 46.04 ? 7 TYR A CZ 1 ATOM 45 O OH . TYR A 1 7 ? 33.881 67.529 -4.087 1.00 45.73 ? 7 TYR A OH 1 ATOM 46 N N . ARG A 1 8 ? 28.962 63.009 -9.749 1.00 46.24 ? 8 ARG A N 1 ATOM 47 C CA . ARG A 1 8 ? 27.882 62.322 -10.464 1.00 45.37 ? 8 ARG A CA 1 ATOM 48 C C . ARG A 1 8 ? 27.892 60.859 -10.015 1.00 44.68 ? 8 ARG A C 1 ATOM 49 O O . ARG A 1 8 ? 28.960 60.278 -9.811 1.00 45.34 ? 8 ARG A O 1 ATOM 50 C CB . ARG A 1 8 ? 28.110 62.366 -11.979 1.00 46.09 ? 8 ARG A CB 1 ATOM 51 C CG . ARG A 1 8 ? 28.178 63.750 -12.606 1.00 47.63 ? 8 ARG A CG 1 ATOM 52 C CD . ARG A 1 8 ? 26.834 64.205 -13.154 1.00 48.21 ? 8 ARG A CD 1 ATOM 53 N NE . ARG A 1 8 ? 26.245 63.235 -14.074 1.00 47.88 ? 8 ARG A NE 1 ATOM 54 C CZ . ARG A 1 8 ? 25.048 63.374 -14.640 1.00 49.25 ? 8 ARG A CZ 1 ATOM 55 N NH1 . ARG A 1 8 ? 24.304 64.448 -14.395 1.00 49.74 ? 8 ARG A NH1 1 ATOM 56 N NH2 . ARG A 1 8 ? 24.577 62.420 -15.427 1.00 50.16 ? 8 ARG A NH2 1 ATOM 57 N N . THR A 1 9 ? 26.714 60.262 -9.860 1.00 42.86 ? 9 THR A N 1 ATOM 58 C CA . THR A 1 9 ? 26.628 58.867 -9.447 1.00 40.68 ? 9 THR A CA 1 ATOM 59 C C . THR A 1 9 ? 26.871 58.006 -10.678 1.00 39.63 ? 9 THR A C 1 ATOM 60 O O . THR A 1 9 ? 26.642 58.450 -11.799 1.00 39.46 ? 9 THR A O 1 ATOM 61 C CB . THR A 1 9 ? 25.238 58.527 -8.889 1.00 41.39 ? 9 THR A CB 1 ATOM 62 O OG1 . THR A 1 9 ? 24.275 58.571 -9.949 1.00 42.87 ? 9 THR A OG1 1 ATOM 63 C CG2 . THR A 1 9 ? 24.839 59.516 -7.813 1.00 40.67 ? 9 THR A CG2 1 ATOM 64 N N . GLY A 1 10 ? 27.326 56.776 -10.463 1.00 38.64 ? 10 GLY A N 1 ATOM 65 C CA . GLY A 1 10 ? 27.600 55.877 -11.568 1.00 37.89 ? 10 GLY A CA 1 ATOM 66 C C . GLY A 1 10 ? 26.479 54.905 -11.868 1.00 38.35 ? 10 GLY A C 1 ATOM 67 O O . GLY A 1 10 ? 26.386 54.402 -12.991 1.00 39.33 ? 10 GLY A O 1 ATOM 68 N N . TYR A 1 11 ? 25.635 54.620 -10.875 1.00 38.27 ? 11 TYR A N 1 ATOM 69 C CA . TYR A 1 11 ? 24.515 53.696 -11.082 1.00 37.21 ? 11 TYR A CA 1 ATOM 70 C C . TYR A 1 11 ? 23.194 54.085 -10.404 1.00 36.73 ? 11 TYR A C 1 ATOM 71 O O . TYR A 1 11 ? 22.325 53.236 -10.190 1.00 36.28 ? 11 TYR A O 1 ATOM 72 C CB . TYR A 1 11 ? 24.915 52.276 -10.676 1.00 34.36 ? 11 TYR A CB 1 ATOM 73 C CG . TYR A 1 11 ? 25.375 52.157 -9.256 1.00 32.42 ? 11 TYR A CG 1 ATOM 74 C CD1 . TYR A 1 11 ? 24.459 52.009 -8.215 1.00 32.60 ? 11 TYR A CD1 1 ATOM 75 C CD2 . TYR A 1 11 ? 26.731 52.179 -8.947 1.00 30.85 ? 11 TYR A CD2 1 ATOM 76 C CE1 . TYR A 1 11 ? 24.885 51.879 -6.894 1.00 31.44 ? 11 TYR A CE1 1 ATOM 77 C CE2 . TYR A 1 11 ? 27.168 52.051 -7.638 1.00 30.79 ? 11 TYR A CE2 1 ATOM 78 C CZ . TYR A 1 11 ? 26.243 51.900 -6.617 1.00 30.94 ? 11 TYR A CZ 1 ATOM 79 O OH . TYR A 1 11 ? 26.678 51.750 -5.323 1.00 30.12 ? 11 TYR A OH 1 ATOM 80 N N . HIS A 1 12 ? 23.053 55.365 -10.065 1.00 36.41 ? 12 HIS A N 1 ATOM 81 C CA . HIS A 1 12 ? 21.822 55.884 -9.467 1.00 36.04 ? 12 HIS A CA 1 ATOM 82 C C . HIS A 1 12 ? 21.124 56.701 -10.552 1.00 36.44 ? 12 HIS A C 1 ATOM 83 O O . HIS A 1 12 ? 21.780 57.270 -11.424 1.00 37.00 ? 12 HIS A O 1 ATOM 84 C CB . HIS A 1 12 ? 22.117 56.806 -8.278 1.00 34.82 ? 12 HIS A CB 1 ATOM 85 C CG . HIS A 1 12 ? 22.365 56.087 -6.991 1.00 34.77 ? 12 HIS A CG 1 ATOM 86 N ND1 . HIS A 1 12 ? 23.527 55.392 -6.739 1.00 34.09 ? 12 HIS A ND1 1 ATOM 87 C CD2 . HIS A 1 12 ? 21.591 55.944 -5.887 1.00 34.26 ? 12 HIS A CD2 1 ATOM 88 C CE1 . HIS A 1 12 ? 23.458 54.849 -5.535 1.00 35.11 ? 12 HIS A CE1 1 ATOM 89 N NE2 . HIS A 1 12 ? 22.294 55.169 -4.998 1.00 34.06 ? 12 HIS A NE2 1 ATOM 90 N N . PHE A 1 13 ? 19.803 56.772 -10.514 1.00 36.38 ? 13 PHE A N 1 ATOM 91 C CA . PHE A 1 13 ? 19.118 57.551 -11.526 1.00 37.09 ? 13 PHE A CA 1 ATOM 92 C C . PHE A 1 13 ? 19.253 59.054 -11.317 1.00 38.75 ? 13 PHE A C 1 ATOM 93 O O . PHE A 1 13 ? 19.155 59.553 -10.197 1.00 40.85 ? 13 PHE A O 1 ATOM 94 C CB . PHE A 1 13 ? 17.636 57.222 -11.567 1.00 35.35 ? 13 PHE A CB 1 ATOM 95 C CG . PHE A 1 13 ? 16.918 57.925 -12.664 1.00 34.73 ? 13 PHE A CG 1 ATOM 96 C CD1 . PHE A 1 13 ? 16.898 57.389 -13.949 1.00 34.23 ? 13 PHE A CD1 1 ATOM 97 C CD2 . PHE A 1 13 ? 16.348 59.177 -12.447 1.00 34.46 ? 13 PHE A CD2 1 ATOM 98 C CE1 . PHE A 1 13 ? 16.316 58.090 -15.008 1.00 35.02 ? 13 PHE A CE1 1 ATOM 99 C CE2 . PHE A 1 13 ? 15.765 59.890 -13.498 1.00 35.17 ? 13 PHE A CE2 1 ATOM 100 C CZ . PHE A 1 13 ? 15.754 59.346 -14.783 1.00 35.07 ? 13 PHE A CZ 1 ATOM 101 N N . GLN A 1 14 ? 19.465 59.770 -12.413 1.00 40.15 ? 14 GLN A N 1 ATOM 102 C CA . GLN A 1 14 ? 19.575 61.221 -12.393 1.00 40.96 ? 14 GLN A CA 1 ATOM 103 C C . GLN A 1 14 ? 19.571 61.702 -13.836 1.00 41.15 ? 14 GLN A C 1 ATOM 104 O O . GLN A 1 14 ? 20.116 61.039 -14.720 1.00 42.04 ? 14 GLN A O 1 ATOM 105 C CB . GLN A 1 14 ? 20.851 61.676 -11.664 1.00 41.54 ? 14 GLN A CB 1 ATOM 106 C CG . GLN A 1 14 ? 22.179 61.219 -12.254 1.00 44.15 ? 14 GLN A CG 1 ATOM 107 C CD . GLN A 1 14 ? 23.369 61.802 -11.495 1.00 45.51 ? 14 GLN A CD 1 ATOM 108 O OE1 . GLN A 1 14 ? 23.555 63.018 -11.450 1.00 46.37 ? 14 GLN A OE1 1 ATOM 109 N NE2 . GLN A 1 14 ? 24.170 60.935 -10.890 1.00 45.91 ? 14 GLN A NE2 1 ATOM 110 N N . PRO A 1 15 ? 18.924 62.846 -14.102 1.00 41.24 ? 15 PRO A N 1 ATOM 111 C CA . PRO A 1 15 ? 18.877 63.371 -15.470 1.00 40.28 ? 15 PRO A CA 1 ATOM 112 C C . PRO A 1 15 ? 20.254 63.777 -15.972 1.00 39.52 ? 15 PRO A C 1 ATOM 113 O O . PRO A 1 15 ? 21.178 63.995 -15.175 1.00 39.87 ? 15 PRO A O 1 ATOM 114 C CB . PRO A 1 15 ? 17.922 64.558 -15.354 1.00 40.34 ? 15 PRO A CB 1 ATOM 115 C CG . PRO A 1 15 ? 18.161 65.037 -13.954 1.00 41.71 ? 15 PRO A CG 1 ATOM 116 C CD . PRO A 1 15 ? 18.221 63.744 -13.168 1.00 41.59 ? 15 PRO A CD 1 ATOM 117 N N . PRO A 1 16 ? 20.412 63.866 -17.304 1.00 38.31 ? 16 PRO A N 1 ATOM 118 C CA . PRO A 1 16 ? 21.681 64.249 -17.925 1.00 37.19 ? 16 PRO A CA 1 ATOM 119 C C . PRO A 1 16 ? 22.239 65.507 -17.271 1.00 37.13 ? 16 PRO A C 1 ATOM 120 O O . PRO A 1 16 ? 23.450 65.698 -17.209 1.00 36.31 ? 16 PRO A O 1 ATOM 121 C CB . PRO A 1 16 ? 21.293 64.471 -19.381 1.00 36.34 ? 16 PRO A CB 1 ATOM 122 C CG . PRO A 1 16 ? 20.214 63.456 -19.592 1.00 37.07 ? 16 PRO A CG 1 ATOM 123 C CD . PRO A 1 16 ? 19.385 63.605 -18.330 1.00 38.02 ? 16 PRO A CD 1 ATOM 124 N N . SER A 1 17 ? 21.341 66.353 -16.769 1.00 37.75 ? 17 SER A N 1 ATOM 125 C CA . SER A 1 17 ? 21.723 67.598 -16.110 1.00 37.31 ? 17 SER A CA 1 ATOM 126 C C . SER A 1 17 ? 20.514 68.290 -15.512 1.00 37.44 ? 17 SER A C 1 ATOM 127 O O . SER A 1 17 ? 19.379 67.831 -15.662 1.00 37.20 ? 17 SER A O 1 ATOM 128 C CB . SER A 1 17 ? 22.342 68.544 -17.115 1.00 38.02 ? 17 SER A CB 1 ATOM 129 O OG . SER A 1 17 ? 21.364 68.907 -18.070 1.00 41.61 ? 17 SER A OG 1 ATOM 130 N N . ASN A 1 18 ? 20.778 69.409 -14.845 1.00 38.55 ? 18 ASN A N 1 ATOM 131 C CA . ASN A 1 18 ? 19.749 70.240 -14.220 1.00 39.80 ? 18 ASN A CA 1 ATOM 132 C C . ASN A 1 18 ? 19.154 69.745 -12.915 1.00 39.49 ? 18 ASN A C 1 ATOM 133 O O . ASN A 1 18 ? 19.691 68.863 -12.256 1.00 41.42 ? 18 ASN A O 1 ATOM 134 C CB . ASN A 1 18 ? 18.618 70.524 -15.206 1.00 41.69 ? 18 ASN A CB 1 ATOM 135 C CG . ASN A 1 18 ? 19.063 71.400 -16.352 1.00 43.73 ? 18 ASN A CG 1 ATOM 136 O OD1 . ASN A 1 18 ? 19.684 72.444 -16.139 1.00 44.75 ? 18 ASN A OD1 1 ATOM 137 N ND2 . ASN A 1 18 ? 18.748 70.987 -17.576 1.00 44.86 ? 18 ASN A ND2 1 ATOM 138 N N . TRP A 1 19 ? 18.022 70.329 -12.556 1.00 38.39 ? 19 TRP A N 1 ATOM 139 C CA . TRP A 1 19 ? 17.350 70.010 -11.316 1.00 37.89 ? 19 TRP A CA 1 ATOM 140 C C . TRP A 1 19 ? 16.317 68.922 -11.416 1.00 38.64 ? 19 TRP A C 1 ATOM 141 O O . TRP A 1 19 ? 15.512 68.905 -12.344 1.00 41.07 ? 19 TRP A O 1 ATOM 142 C CB . TRP A 1 19 ? 16.694 71.276 -10.778 1.00 37.95 ? 19 TRP A CB 1 ATOM 143 C CG . TRP A 1 19 ? 15.700 71.060 -9.700 1.00 37.56 ? 19 TRP A CG 1 ATOM 144 C CD1 . TRP A 1 19 ? 14.396 70.682 -9.842 1.00 37.54 ? 19 TRP A CD1 1 ATOM 145 C CD2 . TRP A 1 19 ? 15.919 71.235 -8.303 1.00 38.31 ? 19 TRP A CD2 1 ATOM 146 N NE1 . TRP A 1 19 ? 13.785 70.618 -8.612 1.00 37.92 ? 19 TRP A NE1 1 ATOM 147 C CE2 . TRP A 1 19 ? 14.701 70.952 -7.647 1.00 38.57 ? 19 TRP A CE2 1 ATOM 148 C CE3 . TRP A 1 19 ? 17.032 71.604 -7.534 1.00 37.61 ? 19 TRP A CE3 1 ATOM 149 C CZ2 . TRP A 1 19 ? 14.561 71.029 -6.260 1.00 38.48 ? 19 TRP A CZ2 1 ATOM 150 C CZ3 . TRP A 1 19 ? 16.893 71.678 -6.156 1.00 38.09 ? 19 TRP A CZ3 1 ATOM 151 C CH2 . TRP A 1 19 ? 15.666 71.392 -5.534 1.00 38.27 ? 19 TRP A CH2 1 ATOM 152 N N . MET A 1 20 ? 16.340 68.026 -10.435 1.00 37.72 ? 20 MET A N 1 ATOM 153 C CA . MET A 1 20 ? 15.386 66.935 -10.343 1.00 36.35 ? 20 MET A CA 1 ATOM 154 C C . MET A 1 20 ? 15.027 66.749 -8.893 1.00 36.10 ? 20 MET A C 1 ATOM 155 O O . MET A 1 20 ? 15.890 66.838 -8.025 1.00 37.01 ? 20 MET A O 1 ATOM 156 C CB . MET A 1 20 ? 15.977 65.618 -10.835 1.00 35.92 ? 20 MET A CB 1 ATOM 157 C CG . MET A 1 20 ? 15.152 64.400 -10.385 1.00 35.63 ? 20 MET A CG 1 ATOM 158 S SD . MET A 1 20 ? 15.865 62.802 -10.825 1.00 34.39 ? 20 MET A SD 1 ATOM 159 C CE . MET A 1 20 ? 17.160 62.685 -9.633 1.00 34.31 ? 20 MET A CE 1 ATOM 160 N N . ASN A 1 21 ? 13.752 66.514 -8.623 1.00 35.72 ? 21 ASN A N 1 ATOM 161 C CA . ASN A 1 21 ? 13.338 66.244 -7.262 1.00 35.71 ? 21 ASN A CA 1 ATOM 162 C C . ASN A 1 21 ? 12.323 65.103 -7.216 1.00 35.38 ? 21 ASN A C 1 ATOM 163 O O . ASN A 1 21 ? 12.587 64.037 -7.764 1.00 35.72 ? 21 ASN A O 1 ATOM 164 C CB . ASN A 1 21 ? 12.852 67.523 -6.521 1.00 36.60 ? 21 ASN A CB 1 ATOM 165 C CG . ASN A 1 21 ? 11.731 68.265 -7.229 1.00 36.48 ? 21 ASN A CG 1 ATOM 166 O OD1 . ASN A 1 21 ? 11.909 68.798 -8.325 1.00 38.48 ? 21 ASN A OD1 1 ATOM 167 N ND2 . ASN A 1 21 ? 10.576 68.331 -6.582 1.00 34.13 ? 21 ASN A ND2 1 ATOM 168 N N . ASP A 1 22 ? 11.185 65.314 -6.569 1.00 35.40 ? 22 ASP A N 1 ATOM 169 C CA . ASP A 1 22 ? 10.156 64.287 -6.419 1.00 35.53 ? 22 ASP A CA 1 ATOM 170 C C . ASP A 1 22 ? 9.989 63.241 -7.519 1.00 35.84 ? 22 ASP A C 1 ATOM 171 O O . ASP A 1 22 ? 9.729 63.589 -8.670 1.00 37.80 ? 22 ASP A O 1 ATOM 172 C CB . ASP A 1 22 ? 8.811 64.960 -6.224 1.00 36.84 ? 22 ASP A CB 1 ATOM 173 C CG . ASP A 1 22 ? 8.753 65.777 -4.968 1.00 38.16 ? 22 ASP A CG 1 ATOM 174 O OD1 . ASP A 1 22 ? 9.757 66.445 -4.643 1.00 40.35 ? 22 ASP A OD1 1 ATOM 175 O OD2 . ASP A 1 22 ? 7.693 65.759 -4.317 1.00 39.78 ? 22 ASP A OD2 1 ATOM 176 N N . PRO A 1 23 ? 10.141 61.944 -7.188 1.00 34.98 ? 23 PRO A N 1 ATOM 177 C CA . PRO A 1 23 ? 9.967 60.913 -8.215 1.00 35.64 ? 23 PRO A CA 1 ATOM 178 C C . PRO A 1 23 ? 8.473 60.901 -8.522 1.00 37.20 ? 23 PRO A C 1 ATOM 179 O O . PRO A 1 23 ? 7.659 61.041 -7.609 1.00 39.14 ? 23 PRO A O 1 ATOM 180 C CB . PRO A 1 23 ? 10.417 59.645 -7.507 1.00 34.65 ? 23 PRO A CB 1 ATOM 181 C CG . PRO A 1 23 ? 10.058 59.914 -6.095 1.00 34.12 ? 23 PRO A CG 1 ATOM 182 C CD . PRO A 1 23 ? 10.552 61.329 -5.919 1.00 34.51 ? 23 PRO A CD 1 ATOM 183 N N . ASN A 1 24 ? 8.108 60.729 -9.791 1.00 37.88 ? 24 ASN A N 1 ATOM 184 C CA . ASN A 1 24 ? 6.699 60.761 -10.185 1.00 37.22 ? 24 ASN A CA 1 ATOM 185 C C . ASN A 1 24 ? 6.134 59.551 -10.917 1.00 37.57 ? 24 ASN A C 1 ATOM 186 O O . ASN A 1 24 ? 6.831 58.880 -11.671 1.00 37.76 ? 24 ASN A O 1 ATOM 187 C CB . ASN A 1 24 ? 6.449 61.999 -11.044 1.00 36.34 ? 24 ASN A CB 1 ATOM 188 C CG . ASN A 1 24 ? 6.452 63.280 -10.239 1.00 35.68 ? 24 ASN A CG 1 ATOM 189 O OD1 . ASN A 1 24 ? 6.502 64.372 -10.800 1.00 35.89 ? 24 ASN A OD1 1 ATOM 190 N ND2 . ASN A 1 24 ? 6.383 63.155 -8.918 1.00 33.38 ? 24 ASN A ND2 1 ATOM 191 N N . GLY A 1 25 ? 4.845 59.309 -10.695 1.00 38.12 ? 25 GLY A N 1 ATOM 192 C CA . GLY A 1 25 ? 4.137 58.210 -11.327 1.00 38.15 ? 25 GLY A CA 1 ATOM 193 C C . GLY A 1 25 ? 4.928 56.973 -11.700 1.00 38.87 ? 25 GLY A C 1 ATOM 194 O O . GLY A 1 25 ? 4.924 56.584 -12.862 1.00 39.41 ? 25 GLY A O 1 ATOM 195 N N . PRO A 1 26 ? 5.622 56.329 -10.749 1.00 39.43 ? 26 PRO A N 1 ATOM 196 C CA . PRO A 1 26 ? 6.387 55.129 -11.093 1.00 39.34 ? 26 PRO A CA 1 ATOM 197 C C . PRO A 1 26 ? 5.400 54.021 -11.430 1.00 40.05 ? 26 PRO A C 1 ATOM 198 O O . PRO A 1 26 ? 4.337 53.927 -10.813 1.00 40.57 ? 26 PRO A O 1 ATOM 199 C CB . PRO A 1 26 ? 7.152 54.827 -9.807 1.00 39.02 ? 26 PRO A CB 1 ATOM 200 C CG . PRO A 1 26 ? 7.233 56.161 -9.125 1.00 38.13 ? 26 PRO A CG 1 ATOM 201 C CD . PRO A 1 26 ? 5.863 56.708 -9.349 1.00 38.43 ? 26 PRO A CD 1 ATOM 202 N N . MET A 1 27 ? 5.730 53.182 -12.404 1.00 39.79 ? 27 MET A N 1 ATOM 203 C CA . MET A 1 27 ? 4.819 52.101 -12.763 1.00 39.89 ? 27 MET A CA 1 ATOM 204 C C . MET A 1 27 ? 5.466 51.107 -13.702 1.00 40.05 ? 27 MET A C 1 ATOM 205 O O . MET A 1 27 ? 6.431 51.423 -14.395 1.00 41.46 ? 27 MET A O 1 ATOM 206 C CB . MET A 1 27 ? 3.573 52.665 -13.450 1.00 39.84 ? 27 MET A CB 1 ATOM 207 C CG . MET A 1 27 ? 3.840 53.142 -14.869 1.00 39.76 ? 27 MET A CG 1 ATOM 208 S SD . MET A 1 27 ? 2.373 53.551 -15.833 1.00 38.73 ? 27 MET A SD 1 ATOM 209 C CE . MET A 1 27 ? 3.011 54.912 -16.809 1.00 38.68 ? 27 MET A CE 1 ATOM 210 N N . LEU A 1 28 ? 4.928 49.898 -13.720 1.00 39.59 ? 28 LEU A N 1 ATOM 211 C CA . LEU A 1 28 ? 5.418 48.874 -14.624 1.00 38.51 ? 28 LEU A CA 1 ATOM 212 C C . LEU A 1 28 ? 4.275 48.652 -15.595 1.00 39.23 ? 28 LEU A C 1 ATOM 213 O O . LEU A 1 28 ? 3.219 48.147 -15.201 1.00 40.13 ? 28 LEU A O 1 ATOM 214 C CB . LEU A 1 28 ? 5.701 47.567 -13.889 1.00 38.37 ? 28 LEU A CB 1 ATOM 215 C CG . LEU A 1 28 ? 5.925 46.434 -14.892 1.00 38.03 ? 28 LEU A CG 1 ATOM 216 C CD1 . LEU A 1 28 ? 7.284 46.633 -15.512 1.00 39.44 ? 28 LEU A CD1 1 ATOM 217 C CD2 . LEU A 1 28 ? 5.836 45.064 -14.245 1.00 36.30 ? 28 LEU A CD2 1 ATOM 218 N N . TYR A 1 29 ? 4.471 49.026 -16.855 1.00 39.58 ? 29 TYR A N 1 ATOM 219 C CA . TYR A 1 29 ? 3.419 48.850 -17.854 1.00 39.61 ? 29 TYR A CA 1 ATOM 220 C C . TYR A 1 29 ? 3.866 48.165 -19.135 1.00 39.92 ? 29 TYR A C 1 ATOM 221 O O . TYR A 1 29 ? 4.827 48.591 -19.778 1.00 40.01 ? 29 TYR A O 1 ATOM 222 C CB . TYR A 1 29 ? 2.807 50.193 -18.236 1.00 39.20 ? 29 TYR A CB 1 ATOM 223 C CG . TYR A 1 29 ? 1.679 50.062 -19.225 1.00 38.41 ? 29 TYR A CG 1 ATOM 224 C CD1 . TYR A 1 29 ? 0.411 49.674 -18.808 1.00 36.96 ? 29 TYR A CD1 1 ATOM 225 C CD2 . TYR A 1 29 ? 1.880 50.320 -20.581 1.00 38.32 ? 29 TYR A CD2 1 ATOM 226 C CE1 . TYR A 1 29 ? -0.637 49.549 -19.712 1.00 38.50 ? 29 TYR A CE1 1 ATOM 227 C CE2 . TYR A 1 29 ? 0.839 50.197 -21.500 1.00 38.94 ? 29 TYR A CE2 1 ATOM 228 C CZ . TYR A 1 29 ? -0.420 49.813 -21.059 1.00 38.69 ? 29 TYR A CZ 1 ATOM 229 O OH . TYR A 1 29 ? -1.464 49.710 -21.956 1.00 36.27 ? 29 TYR A OH 1 ATOM 230 N N . GLN A 1 30 ? 3.146 47.113 -19.509 1.00 40.29 ? 30 GLN A N 1 ATOM 231 C CA . GLN A 1 30 ? 3.444 46.386 -20.731 1.00 39.88 ? 30 GLN A CA 1 ATOM 232 C C . GLN A 1 30 ? 4.925 46.012 -20.822 1.00 38.36 ? 30 GLN A C 1 ATOM 233 O O . GLN A 1 30 ? 5.534 46.125 -21.888 1.00 36.67 ? 30 GLN A O 1 ATOM 234 C CB . GLN A 1 30 ? 3.049 47.244 -21.937 1.00 41.86 ? 30 GLN A CB 1 ATOM 235 C CG . GLN A 1 30 ? 2.384 46.475 -23.067 1.00 45.82 ? 30 GLN A CG 1 ATOM 236 C CD . GLN A 1 30 ? 1.194 45.674 -22.583 1.00 46.84 ? 30 GLN A CD 1 ATOM 237 O OE1 . GLN A 1 30 ? 0.370 46.182 -21.825 1.00 47.93 ? 30 GLN A OE1 1 ATOM 238 N NE2 . GLN A 1 30 ? 1.094 44.417 -23.021 1.00 47.18 ? 30 GLN A NE2 1 ATOM 239 N N . GLY A 1 31 ? 5.501 45.595 -19.695 1.00 37.08 ? 31 GLY A N 1 ATOM 240 C CA . GLY A 1 31 ? 6.898 45.188 -19.671 1.00 35.98 ? 31 GLY A CA 1 ATOM 241 C C . GLY A 1 31 ? 7.952 46.266 -19.513 1.00 35.45 ? 31 GLY A C 1 ATOM 242 O O . GLY A 1 31 ? 9.130 45.973 -19.330 1.00 35.17 ? 31 GLY A O 1 ATOM 243 N N . VAL A 1 32 ? 7.540 47.518 -19.580 1.00 35.93 ? 32 VAL A N 1 ATOM 244 C CA . VAL A 1 32 ? 8.480 48.610 -19.444 1.00 37.29 ? 32 VAL A CA 1 ATOM 245 C C . VAL A 1 32 ? 8.325 49.303 -18.087 1.00 38.43 ? 32 VAL A C 1 ATOM 246 O O . VAL A 1 32 ? 7.208 49.601 -17.659 1.00 39.81 ? 32 VAL A O 1 ATOM 247 C CB . VAL A 1 32 ? 8.265 49.629 -20.582 1.00 36.83 ? 32 VAL A CB 1 ATOM 248 C CG1 . VAL A 1 32 ? 9.131 50.863 -20.374 1.00 38.72 ? 32 VAL A CG1 1 ATOM 249 C CG2 . VAL A 1 32 ? 8.603 48.979 -21.905 1.00 37.53 ? 32 VAL A CG2 1 ATOM 250 N N . TYR A 1 33 ? 9.442 49.528 -17.399 1.00 37.88 ? 33 TYR A N 1 ATOM 251 C CA . TYR A 1 33 ? 9.419 50.226 -16.113 1.00 36.23 ? 33 TYR A CA 1 ATOM 252 C C . TYR A 1 33 ? 9.447 51.717 -16.418 1.00 36.40 ? 33 TYR A C 1 ATOM 253 O O . TYR A 1 33 ? 10.409 52.222 -16.999 1.00 37.25 ? 33 TYR A O 1 ATOM 254 C CB . TYR A 1 33 ? 10.638 49.863 -15.275 1.00 35.09 ? 33 TYR A CB 1 ATOM 255 C CG . TYR A 1 33 ? 10.531 48.524 -14.610 1.00 34.53 ? 33 TYR A CG 1 ATOM 256 C CD1 . TYR A 1 33 ? 9.647 48.327 -13.559 1.00 34.38 ? 33 TYR A CD1 1 ATOM 257 C CD2 . TYR A 1 33 ? 11.303 47.448 -15.035 1.00 33.79 ? 33 TYR A CD2 1 ATOM 258 C CE1 . TYR A 1 33 ? 9.528 47.091 -12.940 1.00 34.40 ? 33 TYR A CE1 1 ATOM 259 C CE2 . TYR A 1 33 ? 11.191 46.206 -14.425 1.00 34.58 ? 33 TYR A CE2 1 ATOM 260 C CZ . TYR A 1 33 ? 10.302 46.037 -13.375 1.00 34.33 ? 33 TYR A CZ 1 ATOM 261 O OH . TYR A 1 33 ? 10.206 44.818 -12.746 1.00 35.05 ? 33 TYR A OH 1 ATOM 262 N N . HIS A 1 34 ? 8.392 52.421 -16.037 1.00 35.38 ? 34 HIS A N 1 ATOM 263 C CA . HIS A 1 34 ? 8.317 53.844 -16.301 1.00 34.59 ? 34 HIS A CA 1 ATOM 264 C C . HIS A 1 34 ? 8.676 54.665 -15.086 1.00 35.32 ? 34 HIS A C 1 ATOM 265 O O . HIS A 1 34 ? 8.158 54.429 -13.996 1.00 37.43 ? 34 HIS A O 1 ATOM 266 C CB . HIS A 1 34 ? 6.905 54.214 -16.756 1.00 34.28 ? 34 HIS A CB 1 ATOM 267 C CG . HIS A 1 34 ? 6.600 53.802 -18.159 1.00 35.19 ? 34 HIS A CG 1 ATOM 268 N ND1 . HIS A 1 34 ? 6.983 54.550 -19.253 1.00 35.28 ? 34 HIS A ND1 1 ATOM 269 C CD2 . HIS A 1 34 ? 5.995 52.697 -18.653 1.00 35.79 ? 34 HIS A CD2 1 ATOM 270 C CE1 . HIS A 1 34 ? 6.631 53.921 -20.358 1.00 36.02 ? 34 HIS A CE1 1 ATOM 271 N NE2 . HIS A 1 34 ? 6.030 52.793 -20.023 1.00 37.02 ? 34 HIS A NE2 1 ATOM 272 N N . PHE A 1 35 ? 9.579 55.619 -15.263 1.00 35.02 ? 35 PHE A N 1 ATOM 273 C CA . PHE A 1 35 ? 9.932 56.500 -14.165 1.00 35.48 ? 35 PHE A CA 1 ATOM 274 C C . PHE A 1 35 ? 9.722 57.927 -14.633 1.00 35.71 ? 35 PHE A C 1 ATOM 275 O O . PHE A 1 35 ? 9.992 58.255 -15.790 1.00 36.89 ? 35 PHE A O 1 ATOM 276 C CB . PHE A 1 35 ? 11.384 56.339 -13.738 1.00 35.93 ? 35 PHE A CB 1 ATOM 277 C CG . PHE A 1 35 ? 11.752 57.203 -12.564 1.00 36.93 ? 35 PHE A CG 1 ATOM 278 C CD1 . PHE A 1 35 ? 11.174 56.972 -11.311 1.00 35.80 ? 35 PHE A CD1 1 ATOM 279 C CD2 . PHE A 1 35 ? 12.632 58.274 -12.716 1.00 36.44 ? 35 PHE A CD2 1 ATOM 280 C CE1 . PHE A 1 35 ? 11.463 57.794 -10.228 1.00 35.67 ? 35 PHE A CE1 1 ATOM 281 C CE2 . PHE A 1 35 ? 12.931 59.107 -11.636 1.00 36.30 ? 35 PHE A CE2 1 ATOM 282 C CZ . PHE A 1 35 ? 12.344 58.864 -10.391 1.00 36.75 ? 35 PHE A CZ 1 ATOM 283 N N . PHE A 1 36 ? 9.240 58.773 -13.735 1.00 34.62 ? 36 PHE A N 1 ATOM 284 C CA . PHE A 1 36 ? 9.006 60.173 -14.055 1.00 34.89 ? 36 PHE A CA 1 ATOM 285 C C . PHE A 1 36 ? 9.575 60.957 -12.891 1.00 34.74 ? 36 PHE A C 1 ATOM 286 O O . PHE A 1 36 ? 9.802 60.379 -11.840 1.00 35.22 ? 36 PHE A O 1 ATOM 287 C CB . PHE A 1 36 ? 7.512 60.440 -14.174 1.00 35.73 ? 36 PHE A CB 1 ATOM 288 C CG . PHE A 1 36 ? 6.847 59.709 -15.303 1.00 34.87 ? 36 PHE A CG 1 ATOM 289 C CD1 . PHE A 1 36 ? 6.858 60.235 -16.590 1.00 35.84 ? 36 PHE A CD1 1 ATOM 290 C CD2 . PHE A 1 36 ? 6.161 58.523 -15.073 1.00 34.19 ? 36 PHE A CD2 1 ATOM 291 C CE1 . PHE A 1 36 ? 6.182 59.596 -17.630 1.00 34.45 ? 36 PHE A CE1 1 ATOM 292 C CE2 . PHE A 1 36 ? 5.485 57.875 -16.107 1.00 33.34 ? 36 PHE A CE2 1 ATOM 293 C CZ . PHE A 1 36 ? 5.496 58.416 -17.383 1.00 33.34 ? 36 PHE A CZ 1 ATOM 294 N N . TYR A 1 37 ? 9.806 62.257 -13.062 1.00 34.71 ? 37 TYR A N 1 ATOM 295 C CA . TYR A 1 37 ? 10.359 63.068 -11.976 1.00 34.55 ? 37 TYR A CA 1 ATOM 296 C C . TYR A 1 37 ? 10.184 64.569 -12.132 1.00 35.38 ? 37 TYR A C 1 ATOM 297 O O . TYR A 1 37 ? 10.239 65.100 -13.239 1.00 35.49 ? 37 TYR A O 1 ATOM 298 C CB . TYR A 1 37 ? 11.856 62.799 -11.817 1.00 34.83 ? 37 TYR A CB 1 ATOM 299 C CG . TYR A 1 37 ? 12.642 62.911 -13.105 1.00 35.83 ? 37 TYR A CG 1 ATOM 300 C CD1 . TYR A 1 37 ? 12.625 61.878 -14.034 1.00 36.78 ? 37 TYR A CD1 1 ATOM 301 C CD2 . TYR A 1 37 ? 13.404 64.044 -13.401 1.00 35.62 ? 37 TYR A CD2 1 ATOM 302 C CE1 . TYR A 1 37 ? 13.348 61.959 -15.226 1.00 36.92 ? 37 TYR A CE1 1 ATOM 303 C CE2 . TYR A 1 37 ? 14.136 64.134 -14.602 1.00 34.28 ? 37 TYR A CE2 1 ATOM 304 C CZ . TYR A 1 37 ? 14.095 63.078 -15.501 1.00 35.95 ? 37 TYR A CZ 1 ATOM 305 O OH . TYR A 1 37 ? 14.803 63.096 -16.676 1.00 37.45 ? 37 TYR A OH 1 ATOM 306 N N . GLN A 1 38 ? 9.981 65.251 -11.010 1.00 36.01 ? 38 GLN A N 1 ATOM 307 C CA . GLN A 1 38 ? 9.860 66.700 -11.018 1.00 37.17 ? 38 GLN A CA 1 ATOM 308 C C . GLN A 1 38 ? 11.158 67.231 -11.637 1.00 38.90 ? 38 GLN A C 1 ATOM 309 O O . GLN A 1 38 ? 12.256 66.936 -11.156 1.00 37.92 ? 38 GLN A O 1 ATOM 310 C CB . GLN A 1 38 ? 9.687 67.196 -9.588 1.00 37.12 ? 38 GLN A CB 1 ATOM 311 C CG . GLN A 1 38 ? 8.329 66.863 -9.030 1.00 37.11 ? 38 GLN A CG 1 ATOM 312 C CD . GLN A 1 38 ? 7.246 67.591 -9.781 1.00 38.58 ? 38 GLN A CD 1 ATOM 313 O OE1 . GLN A 1 38 ? 6.994 68.770 -9.536 1.00 38.99 ? 38 GLN A OE1 1 ATOM 314 N NE2 . GLN A 1 38 ? 6.618 66.904 -10.729 1.00 40.09 ? 38 GLN A NE2 1 ATOM 315 N N . TYR A 1 39 ? 11.036 68.014 -12.706 1.00 40.87 ? 39 TYR A N 1 ATOM 316 C CA . TYR A 1 39 ? 12.216 68.514 -13.410 1.00 41.86 ? 39 TYR A CA 1 ATOM 317 C C . TYR A 1 39 ? 12.143 69.979 -13.866 1.00 43.03 ? 39 TYR A C 1 ATOM 318 O O . TYR A 1 39 ? 11.079 70.475 -14.237 1.00 43.19 ? 39 TYR A O 1 ATOM 319 C CB . TYR A 1 39 ? 12.467 67.574 -14.597 1.00 40.24 ? 39 TYR A CB 1 ATOM 320 C CG . TYR A 1 39 ? 13.577 67.954 -15.532 1.00 40.22 ? 39 TYR A CG 1 ATOM 321 C CD1 . TYR A 1 39 ? 13.294 68.404 -16.814 1.00 40.31 ? 39 TYR A CD1 1 ATOM 322 C CD2 . TYR A 1 39 ? 14.912 67.807 -15.162 1.00 40.45 ? 39 TYR A CD2 1 ATOM 323 C CE1 . TYR A 1 39 ? 14.311 68.698 -17.718 1.00 42.76 ? 39 TYR A CE1 1 ATOM 324 C CE2 . TYR A 1 39 ? 15.948 68.097 -16.057 1.00 41.83 ? 39 TYR A CE2 1 ATOM 325 C CZ . TYR A 1 39 ? 15.638 68.542 -17.338 1.00 43.62 ? 39 TYR A CZ 1 ATOM 326 O OH . TYR A 1 39 ? 16.645 68.823 -18.242 1.00 44.69 ? 39 TYR A OH 1 ATOM 327 N N . ASN A 1 40 ? 13.281 70.671 -13.793 1.00 44.19 ? 40 ASN A N 1 ATOM 328 C CA . ASN A 1 40 ? 13.392 72.064 -14.230 1.00 46.07 ? 40 ASN A CA 1 ATOM 329 C C . ASN A 1 40 ? 14.376 72.047 -15.394 1.00 47.03 ? 40 ASN A C 1 ATOM 330 O O . ASN A 1 40 ? 15.592 71.963 -15.205 1.00 46.38 ? 40 ASN A O 1 ATOM 331 C CB . ASN A 1 40 ? 13.926 72.964 -13.113 1.00 47.52 ? 40 ASN A CB 1 ATOM 332 C CG . ASN A 1 40 ? 14.098 74.411 -13.562 1.00 48.75 ? 40 ASN A CG 1 ATOM 333 O OD1 . ASN A 1 40 ? 13.153 75.042 -14.041 1.00 50.06 ? 40 ASN A OD1 1 ATOM 334 N ND2 . ASN A 1 40 ? 15.304 74.941 -13.407 1.00 49.22 ? 40 ASN A ND2 1 ATOM 335 N N . PRO A 1 41 ? 13.854 72.134 -16.622 1.00 48.15 ? 41 PRO A N 1 ATOM 336 C CA . PRO A 1 41 ? 14.642 72.118 -17.856 1.00 48.73 ? 41 PRO A CA 1 ATOM 337 C C . PRO A 1 41 ? 15.583 73.293 -18.047 1.00 49.51 ? 41 PRO A C 1 ATOM 338 O O . PRO A 1 41 ? 16.334 73.336 -19.022 1.00 49.05 ? 41 PRO A O 1 ATOM 339 C CB . PRO A 1 41 ? 13.569 72.091 -18.929 1.00 48.25 ? 41 PRO A CB 1 ATOM 340 C CG . PRO A 1 41 ? 12.526 72.998 -18.327 1.00 47.01 ? 41 PRO A CG 1 ATOM 341 C CD . PRO A 1 41 ? 12.450 72.495 -16.907 1.00 47.38 ? 41 PRO A CD 1 ATOM 342 N N . TYR A 1 42 ? 15.566 74.238 -17.118 1.00 50.22 ? 42 TYR A N 1 ATOM 343 C CA . TYR A 1 42 ? 16.398 75.412 -17.289 1.00 51.05 ? 42 TYR A CA 1 ATOM 344 C C . TYR A 1 42 ? 17.508 75.685 -16.285 1.00 51.76 ? 42 TYR A C 1 ATOM 345 O O . TYR A 1 42 ? 18.315 76.582 -16.519 1.00 53.25 ? 42 TYR A O 1 ATOM 346 C CB . TYR A 1 42 ? 15.501 76.632 -17.377 1.00 50.94 ? 42 TYR A CB 1 ATOM 347 C CG . TYR A 1 42 ? 14.306 76.436 -18.273 1.00 52.12 ? 42 TYR A CG 1 ATOM 348 C CD1 . TYR A 1 42 ? 13.021 76.675 -17.799 1.00 52.28 ? 42 TYR A CD1 1 ATOM 349 C CD2 . TYR A 1 42 ? 14.458 76.072 -19.608 1.00 53.01 ? 42 TYR A CD2 1 ATOM 350 C CE1 . TYR A 1 42 ? 11.914 76.571 -18.627 1.00 52.49 ? 42 TYR A CE1 1 ATOM 351 C CE2 . TYR A 1 42 ? 13.353 75.962 -20.453 1.00 53.60 ? 42 TYR A CE2 1 ATOM 352 C CZ . TYR A 1 42 ? 12.082 76.220 -19.953 1.00 53.62 ? 42 TYR A CZ 1 ATOM 353 O OH . TYR A 1 42 ? 10.981 76.166 -20.785 1.00 54.40 ? 42 TYR A OH 1 ATOM 354 N N . ALA A 1 43 ? 17.568 74.940 -15.183 1.00 51.09 ? 43 ALA A N 1 ATOM 355 C CA . ALA A 1 43 ? 18.621 75.173 -14.194 1.00 49.93 ? 43 ALA A CA 1 ATOM 356 C C . ALA A 1 43 ? 18.892 74.007 -13.254 1.00 50.35 ? 43 ALA A C 1 ATOM 357 O O . ALA A 1 43 ? 18.293 72.942 -13.375 1.00 50.95 ? 43 ALA A O 1 ATOM 358 C CB . ALA A 1 43 ? 18.290 76.402 -13.377 1.00 49.39 ? 43 ALA A CB 1 ATOM 359 N N . ALA A 1 44 ? 19.825 74.221 -12.329 1.00 50.50 ? 44 ALA A N 1 ATOM 360 C CA . ALA A 1 44 ? 20.175 73.223 -11.322 1.00 49.88 ? 44 ALA A CA 1 ATOM 361 C C . ALA A 1 44 ? 19.570 73.799 -10.052 1.00 49.84 ? 44 ALA A C 1 ATOM 362 O O . ALA A 1 44 ? 20.156 73.749 -8.967 1.00 50.13 ? 44 ALA A O 1 ATOM 363 C CB . ALA A 1 44 ? 21.692 73.090 -11.188 1.00 48.97 ? 44 ALA A CB 1 ATOM 364 N N . THR A 1 45 ? 18.381 74.364 -10.224 1.00 49.90 ? 45 THR A N 1 ATOM 365 C CA . THR A 1 45 ? 17.644 74.984 -9.141 1.00 51.66 ? 45 THR A CA 1 ATOM 366 C C . THR A 1 45 ? 16.163 74.890 -9.440 1.00 51.43 ? 45 THR A C 1 ATOM 367 O O . THR A 1 45 ? 15.754 74.933 -10.598 1.00 51.94 ? 45 THR A O 1 ATOM 368 C CB . THR A 1 45 ? 17.993 76.471 -9.026 1.00 52.45 ? 45 THR A CB 1 ATOM 369 O OG1 . THR A 1 45 ? 19.409 76.631 -9.137 1.00 54.25 ? 45 THR A OG1 1 ATOM 370 C CG2 . THR A 1 45 ? 17.533 77.026 -7.680 1.00 55.43 ? 45 THR A CG2 1 ATOM 371 N N . PHE A 1 46 ? 15.352 74.767 -8.400 1.00 51.23 ? 46 PHE A N 1 ATOM 372 C CA . PHE A 1 46 ? 13.918 74.702 -8.610 1.00 51.70 ? 46 PHE A CA 1 ATOM 373 C C . PHE A 1 46 ? 13.541 75.916 -9.466 1.00 53.08 ? 46 PHE A C 1 ATOM 374 O O . PHE A 1 46 ? 14.216 76.941 -9.415 1.00 53.11 ? 46 PHE A O 1 ATOM 375 C CB . PHE A 1 46 ? 13.201 74.768 -7.274 1.00 49.88 ? 46 PHE A CB 1 ATOM 376 C CG . PHE A 1 46 ? 11.798 74.275 -7.326 1.00 49.01 ? 46 PHE A CG 1 ATOM 377 C CD1 . PHE A 1 46 ? 11.532 72.918 -7.457 1.00 50.62 ? 46 PHE A CD1 1 ATOM 378 C CD2 . PHE A 1 46 ? 10.739 75.159 -7.237 1.00 48.80 ? 46 PHE A CD2 1 ATOM 379 C CE1 . PHE A 1 46 ? 10.220 72.446 -7.502 1.00 51.91 ? 46 PHE A CE1 1 ATOM 380 C CE2 . PHE A 1 46 ? 9.423 74.703 -7.281 1.00 50.75 ? 46 PHE A CE2 1 ATOM 381 C CZ . PHE A 1 46 ? 9.163 73.341 -7.410 1.00 51.04 ? 46 PHE A CZ 1 ATOM 382 N N . GLY A 1 47 ? 12.478 75.801 -10.254 1.00 54.77 ? 47 GLY A N 1 ATOM 383 C CA . GLY A 1 47 ? 12.065 76.912 -11.095 1.00 55.91 ? 47 GLY A CA 1 ATOM 384 C C . GLY A 1 47 ? 10.574 77.188 -11.021 1.00 56.99 ? 47 GLY A C 1 ATOM 385 O O . GLY A 1 47 ? 9.849 76.538 -10.263 1.00 56.53 ? 47 GLY A O 1 ATOM 386 N N . ASP A 1 48 ? 10.114 78.162 -11.802 1.00 57.80 ? 48 ASP A N 1 ATOM 387 C CA . ASP A 1 48 ? 8.697 78.511 -11.832 1.00 58.10 ? 48 ASP A CA 1 ATOM 388 C C . ASP A 1 48 ? 7.995 77.532 -12.745 1.00 56.74 ? 48 ASP A C 1 ATOM 389 O O . ASP A 1 48 ? 6.777 77.349 -12.666 1.00 56.82 ? 48 ASP A O 1 ATOM 390 C CB . ASP A 1 48 ? 8.497 79.918 -12.387 1.00 60.84 ? 48 ASP A CB 1 ATOM 391 C CG . ASP A 1 48 ? 8.800 80.996 -11.374 1.00 64.46 ? 48 ASP A CG 1 ATOM 392 O OD1 . ASP A 1 48 ? 8.816 82.185 -11.773 1.00 66.64 ? 48 ASP A OD1 1 ATOM 393 O OD2 . ASP A 1 48 ? 9.014 80.664 -10.182 1.00 65.88 ? 48 ASP A OD2 1 ATOM 394 N N . VAL A 1 49 ? 8.788 76.917 -13.617 1.00 54.51 ? 49 VAL A N 1 ATOM 395 C CA . VAL A 1 49 ? 8.290 75.956 -14.582 1.00 51.74 ? 49 VAL A CA 1 ATOM 396 C C . VAL A 1 49 ? 8.875 74.586 -14.312 1.00 50.88 ? 49 VAL A C 1 ATOM 397 O O . VAL A 1 49 ? 10.016 74.298 -14.685 1.00 51.23 ? 49 VAL A O 1 ATOM 398 C CB . VAL A 1 49 ? 8.662 76.365 -16.010 1.00 50.39 ? 49 VAL A CB 1 ATOM 399 C CG1 . VAL A 1 49 ? 8.006 75.436 -17.004 1.00 48.92 ? 49 VAL A CG1 1 ATOM 400 C CG2 . VAL A 1 49 ? 8.246 77.793 -16.254 1.00 49.83 ? 49 VAL A CG2 1 ATOM 401 N N . ILE A 1 50 ? 8.085 73.748 -13.652 1.00 49.47 ? 50 ILE A N 1 ATOM 402 C CA . ILE A 1 50 ? 8.493 72.388 -13.335 1.00 47.56 ? 50 ILE A CA 1 ATOM 403 C C . ILE A 1 50 ? 7.660 71.427 -14.184 1.00 45.61 ? 50 ILE A C 1 ATOM 404 O O . ILE A 1 50 ? 6.423 71.478 -14.179 1.00 45.20 ? 50 ILE A O 1 ATOM 405 C CB . ILE A 1 50 ? 8.279 72.070 -11.827 1.00 47.94 ? 50 ILE A CB 1 ATOM 406 C CG1 . ILE A 1 50 ? 9.157 72.989 -10.967 1.00 47.55 ? 50 ILE A CG1 1 ATOM 407 C CG2 . ILE A 1 50 ? 8.620 70.608 -11.539 1.00 47.81 ? 50 ILE A CG2 1 ATOM 408 C CD1 . ILE A 1 50 ? 10.660 72.781 -11.157 1.00 46.28 ? 50 ILE A CD1 1 ATOM 409 N N . ILE A 1 51 ? 8.347 70.564 -14.924 1.00 42.27 ? 51 ILE A N 1 ATOM 410 C CA . ILE A 1 51 ? 7.690 69.589 -15.774 1.00 39.93 ? 51 ILE A CA 1 ATOM 411 C C . ILE A 1 51 ? 8.045 68.176 -15.312 1.00 40.01 ? 51 ILE A C 1 ATOM 412 O O . ILE A 1 51 ? 8.877 67.997 -14.424 1.00 41.34 ? 51 ILE A O 1 ATOM 413 C CB . ILE A 1 51 ? 8.118 69.769 -17.239 1.00 38.75 ? 51 ILE A CB 1 ATOM 414 C CG1 . ILE A 1 51 ? 9.641 69.701 -17.350 1.00 38.10 ? 51 ILE A CG1 1 ATOM 415 C CG2 . ILE A 1 51 ? 7.628 71.104 -17.755 1.00 39.39 ? 51 ILE A CG2 1 ATOM 416 C CD1 . ILE A 1 51 ? 10.166 69.747 -18.770 1.00 34.38 ? 51 ILE A CD1 1 ATOM 417 N N . TRP A 1 52 ? 7.404 67.178 -15.913 1.00 38.75 ? 52 TRP A N 1 ATOM 418 C CA . TRP A 1 52 ? 7.642 65.776 -15.581 1.00 35.68 ? 52 TRP A CA 1 ATOM 419 C C . TRP A 1 52 ? 8.692 65.159 -16.476 1.00 36.13 ? 52 TRP A C 1 ATOM 420 O O . TRP A 1 52 ? 8.468 65.004 -17.672 1.00 36.16 ? 52 TRP A O 1 ATOM 421 C CB . TRP A 1 52 ? 6.362 64.968 -15.742 1.00 31.72 ? 52 TRP A CB 1 ATOM 422 C CG . TRP A 1 52 ? 5.499 64.987 -14.554 1.00 29.72 ? 52 TRP A CG 1 ATOM 423 C CD1 . TRP A 1 52 ? 5.227 66.053 -13.761 1.00 30.01 ? 52 TRP A CD1 1 ATOM 424 C CD2 . TRP A 1 52 ? 4.752 63.888 -14.027 1.00 29.61 ? 52 TRP A CD2 1 ATOM 425 N NE1 . TRP A 1 52 ? 4.350 65.694 -12.763 1.00 30.53 ? 52 TRP A NE1 1 ATOM 426 C CE2 . TRP A 1 52 ? 4.039 64.367 -12.904 1.00 30.40 ? 52 TRP A CE2 1 ATOM 427 C CE3 . TRP A 1 52 ? 4.612 62.542 -14.395 1.00 28.15 ? 52 TRP A CE3 1 ATOM 428 C CZ2 . TRP A 1 52 ? 3.194 63.548 -12.139 1.00 30.08 ? 52 TRP A CZ2 1 ATOM 429 C CZ3 . TRP A 1 52 ? 3.773 61.723 -13.637 1.00 28.44 ? 52 TRP A CZ3 1 ATOM 430 C CH2 . TRP A 1 52 ? 3.072 62.234 -12.519 1.00 29.60 ? 52 TRP A CH2 1 ATOM 431 N N . GLY A 1 53 ? 9.836 64.808 -15.900 1.00 37.46 ? 53 GLY A N 1 ATOM 432 C CA . GLY A 1 53 ? 10.883 64.172 -16.679 1.00 38.52 ? 53 GLY A CA 1 ATOM 433 C C . GLY A 1 53 ? 10.424 62.756 -16.962 1.00 39.07 ? 53 GLY A C 1 ATOM 434 O O . GLY A 1 53 ? 9.576 62.227 -16.243 1.00 38.97 ? 53 GLY A O 1 ATOM 435 N N . HIS A 1 54 ? 10.971 62.130 -17.995 1.00 39.25 ? 54 HIS A N 1 ATOM 436 C CA . HIS A 1 54 ? 10.546 60.780 -18.334 1.00 40.00 ? 54 HIS A CA 1 ATOM 437 C C . HIS A 1 54 ? 11.746 59.898 -18.656 1.00 40.62 ? 54 HIS A C 1 ATOM 438 O O . HIS A 1 54 ? 12.755 60.370 -19.185 1.00 42.72 ? 54 HIS A O 1 ATOM 439 C CB . HIS A 1 54 ? 9.581 60.843 -19.524 1.00 40.48 ? 54 HIS A CB 1 ATOM 440 C CG . HIS A 1 54 ? 8.829 59.573 -19.777 1.00 41.48 ? 54 HIS A CG 1 ATOM 441 N ND1 . HIS A 1 54 ? 8.776 58.539 -18.867 1.00 41.61 ? 54 HIS A ND1 1 ATOM 442 C CD2 . HIS A 1 54 ? 8.075 59.182 -20.834 1.00 41.75 ? 54 HIS A CD2 1 ATOM 443 C CE1 . HIS A 1 54 ? 8.025 57.566 -19.352 1.00 40.60 ? 54 HIS A CE1 1 ATOM 444 N NE2 . HIS A 1 54 ? 7.587 57.931 -20.543 1.00 40.53 ? 54 HIS A NE2 1 ATOM 445 N N . ALA A 1 55 ? 11.637 58.620 -18.305 1.00 39.17 ? 55 ALA A N 1 ATOM 446 C CA . ALA A 1 55 ? 12.692 57.650 -18.556 1.00 37.09 ? 55 ALA A CA 1 ATOM 447 C C . ALA A 1 55 ? 12.059 56.272 -18.512 1.00 35.88 ? 55 ALA A C 1 ATOM 448 O O . ALA A 1 55 ? 11.058 56.074 -17.823 1.00 35.22 ? 55 ALA A O 1 ATOM 449 C CB . ALA A 1 55 ? 13.781 57.764 -17.494 1.00 37.00 ? 55 ALA A CB 1 ATOM 450 N N . VAL A 1 56 ? 12.629 55.333 -19.263 1.00 34.83 ? 56 VAL A N 1 ATOM 451 C CA . VAL A 1 56 ? 12.124 53.963 -19.288 1.00 34.09 ? 56 VAL A CA 1 ATOM 452 C C . VAL A 1 56 ? 13.246 52.965 -19.048 1.00 33.50 ? 56 VAL A C 1 ATOM 453 O O . VAL A 1 56 ? 14.418 53.246 -19.304 1.00 33.07 ? 56 VAL A O 1 ATOM 454 C CB . VAL A 1 56 ? 11.441 53.626 -20.630 1.00 33.39 ? 56 VAL A CB 1 ATOM 455 C CG1 . VAL A 1 56 ? 10.106 54.325 -20.723 1.00 33.24 ? 56 VAL A CG1 1 ATOM 456 C CG2 . VAL A 1 56 ? 12.325 54.048 -21.779 1.00 33.59 ? 56 VAL A CG2 1 ATOM 457 N N . SER A 1 57 ? 12.880 51.795 -18.548 1.00 33.19 ? 57 SER A N 1 ATOM 458 C CA . SER A 1 57 ? 13.856 50.760 -18.266 1.00 34.07 ? 57 SER A CA 1 ATOM 459 C C . SER A 1 57 ? 13.236 49.378 -18.285 1.00 34.99 ? 57 SER A C 1 ATOM 460 O O . SER A 1 57 ? 12.028 49.216 -18.082 1.00 34.39 ? 57 SER A O 1 ATOM 461 C CB . SER A 1 57 ? 14.486 50.986 -16.898 1.00 33.46 ? 57 SER A CB 1 ATOM 462 O OG . SER A 1 57 ? 15.350 49.912 -16.566 1.00 33.70 ? 57 SER A OG 1 ATOM 463 N N . TYR A 1 58 ? 14.073 48.378 -18.531 1.00 35.04 ? 58 TYR A N 1 ATOM 464 C CA . TYR A 1 58 ? 13.599 47.009 -18.540 1.00 34.57 ? 58 TYR A CA 1 ATOM 465 C C . TYR A 1 58 ? 14.099 46.285 -17.300 1.00 34.28 ? 58 TYR A C 1 ATOM 466 O O . TYR A 1 58 ? 13.743 45.135 -17.079 1.00 35.38 ? 58 TYR A O 1 ATOM 467 C CB . TYR A 1 58 ? 14.096 46.284 -19.778 1.00 33.79 ? 58 TYR A CB 1 ATOM 468 C CG . TYR A 1 58 ? 13.483 46.770 -21.067 1.00 36.00 ? 58 TYR A CG 1 ATOM 469 C CD1 . TYR A 1 58 ? 12.144 46.526 -21.370 1.00 36.73 ? 58 TYR A CD1 1 ATOM 470 C CD2 . TYR A 1 58 ? 14.249 47.461 -21.995 1.00 36.73 ? 58 TYR A CD2 1 ATOM 471 C CE1 . TYR A 1 58 ? 11.590 46.962 -22.579 1.00 38.63 ? 58 TYR A CE1 1 ATOM 472 C CE2 . TYR A 1 58 ? 13.714 47.899 -23.197 1.00 37.24 ? 58 TYR A CE2 1 ATOM 473 C CZ . TYR A 1 58 ? 12.390 47.649 -23.488 1.00 39.57 ? 58 TYR A CZ 1 ATOM 474 O OH . TYR A 1 58 ? 11.885 48.090 -24.697 1.00 42.15 ? 58 TYR A OH 1 ATOM 475 N N . ASP A 1 59 ? 14.898 46.966 -16.480 1.00 33.47 ? 59 ASP A N 1 ATOM 476 C CA . ASP A 1 59 ? 15.471 46.350 -15.284 1.00 32.77 ? 59 ASP A CA 1 ATOM 477 C C . ASP A 1 59 ? 15.675 47.262 -14.076 1.00 33.08 ? 59 ASP A C 1 ATOM 478 O O . ASP A 1 59 ? 16.313 46.861 -13.106 1.00 33.94 ? 59 ASP A O 1 ATOM 479 C CB . ASP A 1 59 ? 16.820 45.739 -15.638 1.00 33.18 ? 59 ASP A CB 1 ATOM 480 C CG . ASP A 1 59 ? 17.741 46.736 -16.323 1.00 35.13 ? 59 ASP A CG 1 ATOM 481 O OD1 . ASP A 1 59 ? 17.907 47.861 -15.803 1.00 35.97 ? 59 ASP A OD1 1 ATOM 482 O OD2 . ASP A 1 59 ? 18.302 46.398 -17.383 1.00 37.67 ? 59 ASP A OD2 1 ATOM 483 N N . LEU A 1 60 ? 15.161 48.485 -14.135 1.00 33.21 ? 60 LEU A N 1 ATOM 484 C CA . LEU A 1 60 ? 15.301 49.440 -13.028 1.00 32.13 ? 60 LEU A CA 1 ATOM 485 C C . LEU A 1 60 ? 16.750 49.853 -12.740 1.00 32.31 ? 60 LEU A C 1 ATOM 486 O O . LEU A 1 60 ? 17.033 50.489 -11.724 1.00 32.77 ? 60 LEU A O 1 ATOM 487 C CB . LEU A 1 60 ? 14.652 48.872 -11.756 1.00 28.66 ? 60 LEU A CB 1 ATOM 488 C CG . LEU A 1 60 ? 13.120 48.875 -11.733 1.00 26.71 ? 60 LEU A CG 1 ATOM 489 C CD1 . LEU A 1 60 ? 12.593 47.959 -10.660 1.00 25.36 ? 60 LEU A CD1 1 ATOM 490 C CD2 . LEU A 1 60 ? 12.642 50.291 -11.504 1.00 26.32 ? 60 LEU A CD2 1 ATOM 491 N N . VAL A 1 61 ? 17.666 49.504 -13.636 1.00 31.99 ? 61 VAL A N 1 ATOM 492 C CA . VAL A 1 61 ? 19.063 49.865 -13.441 1.00 32.25 ? 61 VAL A CA 1 ATOM 493 C C . VAL A 1 61 ? 19.609 50.660 -14.614 1.00 32.99 ? 61 VAL A C 1 ATOM 494 O O . VAL A 1 61 ? 20.307 51.653 -14.429 1.00 33.82 ? 61 VAL A O 1 ATOM 495 C CB . VAL A 1 61 ? 19.930 48.622 -13.235 1.00 30.84 ? 61 VAL A CB 1 ATOM 496 C CG1 . VAL A 1 61 ? 21.394 49.016 -13.154 1.00 28.42 ? 61 VAL A CG1 1 ATOM 497 C CG2 . VAL A 1 61 ? 19.492 47.914 -11.976 1.00 29.06 ? 61 VAL A CG2 1 ATOM 498 N N . ASN A 1 62 ? 19.296 50.212 -15.822 1.00 32.94 ? 62 ASN A N 1 ATOM 499 C CA . ASN A 1 62 ? 19.748 50.901 -17.020 1.00 33.12 ? 62 ASN A CA 1 ATOM 500 C C . ASN A 1 62 ? 18.564 51.625 -17.619 1.00 34.06 ? 62 ASN A C 1 ATOM 501 O O . ASN A 1 62 ? 17.544 51.004 -17.930 1.00 36.11 ? 62 ASN A O 1 ATOM 502 C CB . ASN A 1 62 ? 20.294 49.897 -18.005 1.00 32.19 ? 62 ASN A CB 1 ATOM 503 C CG . ASN A 1 62 ? 21.367 49.054 -17.402 1.00 32.95 ? 62 ASN A CG 1 ATOM 504 O OD1 . ASN A 1 62 ? 22.467 49.535 -17.108 1.00 33.46 ? 62 ASN A OD1 1 ATOM 505 N ND2 . ASN A 1 62 ? 21.059 47.786 -17.191 1.00 33.11 ? 62 ASN A ND2 1 ATOM 506 N N . TRP A 1 63 ? 18.706 52.934 -17.804 1.00 32.78 ? 63 TRP A N 1 ATOM 507 C CA . TRP A 1 63 ? 17.610 53.736 -18.324 1.00 31.50 ? 63 TRP A CA 1 ATOM 508 C C . TRP A 1 63 ? 17.789 54.443 -19.661 1.00 31.77 ? 63 TRP A C 1 ATOM 509 O O . TRP A 1 63 ? 18.905 54.756 -20.076 1.00 31.75 ? 63 TRP A O 1 ATOM 510 C CB . TRP A 1 63 ? 17.232 54.776 -17.278 1.00 30.29 ? 63 TRP A CB 1 ATOM 511 C CG . TRP A 1 63 ? 16.909 54.177 -15.950 1.00 31.08 ? 63 TRP A CG 1 ATOM 512 C CD1 . TRP A 1 63 ? 17.793 53.750 -14.993 1.00 30.69 ? 63 TRP A CD1 1 ATOM 513 C CD2 . TRP A 1 63 ? 15.604 53.901 -15.443 1.00 30.95 ? 63 TRP A CD2 1 ATOM 514 N NE1 . TRP A 1 63 ? 17.114 53.224 -13.919 1.00 29.11 ? 63 TRP A NE1 1 ATOM 515 C CE2 . TRP A 1 63 ? 15.767 53.304 -14.168 1.00 30.92 ? 63 TRP A CE2 1 ATOM 516 C CE3 . TRP A 1 63 ? 14.306 54.101 -15.942 1.00 29.21 ? 63 TRP A CE3 1 ATOM 517 C CZ2 . TRP A 1 63 ? 14.675 52.904 -13.383 1.00 30.74 ? 63 TRP A CZ2 1 ATOM 518 C CZ3 . TRP A 1 63 ? 13.221 53.706 -15.166 1.00 29.12 ? 63 TRP A CZ3 1 ATOM 519 C CH2 . TRP A 1 63 ? 13.413 53.114 -13.898 1.00 31.26 ? 63 TRP A CH2 1 ATOM 520 N N . ILE A 1 64 ? 16.666 54.681 -20.333 1.00 31.37 ? 64 ILE A N 1 ATOM 521 C CA . ILE A 1 64 ? 16.672 55.416 -21.589 1.00 30.67 ? 64 ILE A CA 1 ATOM 522 C C . ILE A 1 64 ? 15.945 56.715 -21.284 1.00 32.49 ? 64 ILE A C 1 ATOM 523 O O . ILE A 1 64 ? 14.781 56.689 -20.873 1.00 31.48 ? 64 ILE A O 1 ATOM 524 C CB . ILE A 1 64 ? 15.883 54.728 -22.703 1.00 28.37 ? 64 ILE A CB 1 ATOM 525 C CG1 . ILE A 1 64 ? 16.404 53.318 -22.955 1.00 26.48 ? 64 ILE A CG1 1 ATOM 526 C CG2 . ILE A 1 64 ? 16.008 55.539 -23.969 1.00 25.36 ? 64 ILE A CG2 1 ATOM 527 C CD1 . ILE A 1 64 ? 15.576 52.572 -23.972 1.00 24.46 ? 64 ILE A CD1 1 ATOM 528 N N . HIS A 1 65 ? 16.633 57.843 -21.463 1.00 34.84 ? 65 HIS A N 1 ATOM 529 C CA . HIS A 1 65 ? 16.041 59.157 -21.216 1.00 36.53 ? 65 HIS A CA 1 ATOM 530 C C . HIS A 1 65 ? 15.137 59.568 -22.369 1.00 37.48 ? 65 HIS A C 1 ATOM 531 O O . HIS A 1 65 ? 15.520 59.467 -23.534 1.00 38.88 ? 65 HIS A O 1 ATOM 532 C CB . HIS A 1 65 ? 17.132 60.204 -21.038 1.00 37.46 ? 65 HIS A CB 1 ATOM 533 C CG . HIS A 1 65 ? 17.881 60.079 -19.752 1.00 39.89 ? 65 HIS A CG 1 ATOM 534 N ND1 . HIS A 1 65 ? 17.259 60.122 -18.523 1.00 40.92 ? 65 HIS A ND1 1 ATOM 535 C CD2 . HIS A 1 65 ? 19.203 59.931 -19.501 1.00 41.28 ? 65 HIS A CD2 1 ATOM 536 C CE1 . HIS A 1 65 ? 18.168 60.009 -17.570 1.00 41.84 ? 65 HIS A CE1 1 ATOM 537 N NE2 . HIS A 1 65 ? 19.355 59.892 -18.137 1.00 41.27 ? 65 HIS A NE2 1 ATOM 538 N N . LEU A 1 66 ? 13.938 60.029 -22.038 1.00 37.44 ? 66 LEU A N 1 ATOM 539 C CA . LEU A 1 66 ? 12.974 60.452 -23.042 1.00 37.91 ? 66 LEU A CA 1 ATOM 540 C C . LEU A 1 66 ? 12.656 61.928 -22.837 1.00 39.85 ? 66 LEU A C 1 ATOM 541 O O . LEU A 1 66 ? 13.150 62.552 -21.895 1.00 41.03 ? 66 LEU A O 1 ATOM 542 C CB . LEU A 1 66 ? 11.693 59.625 -22.901 1.00 36.52 ? 66 LEU A CB 1 ATOM 543 C CG . LEU A 1 66 ? 11.811 58.104 -23.029 1.00 35.79 ? 66 LEU A CG 1 ATOM 544 C CD1 . LEU A 1 66 ? 10.493 57.431 -22.678 1.00 34.83 ? 66 LEU A CD1 1 ATOM 545 C CD2 . LEU A 1 66 ? 12.216 57.753 -24.447 1.00 36.59 ? 66 LEU A CD2 1 ATOM 546 N N . ASP A 1 67 ? 11.839 62.493 -23.719 1.00 41.40 ? 67 ASP A N 1 ATOM 547 C CA . ASP A 1 67 ? 11.448 63.890 -23.568 1.00 42.78 ? 67 ASP A CA 1 ATOM 548 C C . ASP A 1 67 ? 10.386 63.926 -22.479 1.00 42.68 ? 67 ASP A C 1 ATOM 549 O O . ASP A 1 67 ? 9.783 62.902 -22.153 1.00 43.13 ? 67 ASP A O 1 ATOM 550 C CB . ASP A 1 67 ? 10.847 64.439 -24.863 1.00 45.90 ? 67 ASP A CB 1 ATOM 551 C CG . ASP A 1 67 ? 11.819 64.400 -26.024 1.00 49.95 ? 67 ASP A CG 1 ATOM 552 O OD1 . ASP A 1 67 ? 12.944 64.927 -25.878 1.00 52.89 ? 67 ASP A OD1 1 ATOM 553 O OD2 . ASP A 1 67 ? 11.454 63.852 -27.087 1.00 50.84 ? 67 ASP A OD2 1 ATOM 554 N N . PRO A 1 68 ? 10.132 65.103 -21.904 1.00 42.50 ? 68 PRO A N 1 ATOM 555 C CA . PRO A 1 68 ? 9.116 65.187 -20.852 1.00 43.07 ? 68 PRO A CA 1 ATOM 556 C C . PRO A 1 68 ? 7.776 64.606 -21.295 1.00 43.70 ? 68 PRO A C 1 ATOM 557 O O . PRO A 1 68 ? 7.476 64.543 -22.486 1.00 44.98 ? 68 PRO A O 1 ATOM 558 C CB . PRO A 1 68 ? 9.047 66.679 -20.566 1.00 43.22 ? 68 PRO A CB 1 ATOM 559 C CG . PRO A 1 68 ? 10.471 67.110 -20.791 1.00 42.99 ? 68 PRO A CG 1 ATOM 560 C CD . PRO A 1 68 ? 10.813 66.393 -22.084 1.00 42.75 ? 68 PRO A CD 1 ATOM 561 N N . ALA A 1 69 ? 6.976 64.175 -20.330 1.00 44.24 ? 69 ALA A N 1 ATOM 562 C CA . ALA A 1 69 ? 5.686 63.583 -20.641 1.00 45.42 ? 69 ALA A CA 1 ATOM 563 C C . ALA A 1 69 ? 4.556 64.535 -20.294 1.00 45.63 ? 69 ALA A C 1 ATOM 564 O O . ALA A 1 69 ? 3.636 64.758 -21.087 1.00 46.37 ? 69 ALA A O 1 ATOM 565 C CB . ALA A 1 69 ? 5.517 62.274 -19.881 1.00 45.57 ? 69 ALA A CB 1 ATOM 566 N N . ILE A 1 70 ? 4.630 65.095 -19.098 1.00 45.06 ? 70 ILE A N 1 ATOM 567 C CA . ILE A 1 70 ? 3.610 66.008 -18.636 1.00 44.69 ? 70 ILE A CA 1 ATOM 568 C C . ILE A 1 70 ? 4.233 67.367 -18.404 1.00 45.98 ? 70 ILE A C 1 ATOM 569 O O . ILE A 1 70 ? 5.171 67.510 -17.622 1.00 47.19 ? 70 ILE A O 1 ATOM 570 C CB . ILE A 1 70 ? 2.969 65.460 -17.352 1.00 43.82 ? 70 ILE A CB 1 ATOM 571 C CG1 . ILE A 1 70 ? 2.360 64.092 -17.674 1.00 42.20 ? 70 ILE A CG1 1 ATOM 572 C CG2 . ILE A 1 70 ? 1.928 66.436 -16.804 1.00 42.32 ? 70 ILE A CG2 1 ATOM 573 C CD1 . ILE A 1 70 ? 1.788 63.367 -16.509 1.00 42.52 ? 70 ILE A CD1 1 ATOM 574 N N . TYR A 1 71 ? 3.724 68.360 -19.121 1.00 46.32 ? 71 TYR A N 1 ATOM 575 C CA . TYR A 1 71 ? 4.212 69.728 -19.018 1.00 45.69 ? 71 TYR A CA 1 ATOM 576 C C . TYR A 1 71 ? 3.017 70.612 -19.273 1.00 44.65 ? 71 TYR A C 1 ATOM 577 O O . TYR A 1 71 ? 2.084 70.195 -19.948 1.00 45.91 ? 71 TYR A O 1 ATOM 578 C CB . TYR A 1 71 ? 5.295 69.968 -20.063 1.00 45.93 ? 71 TYR A CB 1 ATOM 579 C CG . TYR A 1 71 ? 4.980 69.358 -21.402 1.00 46.79 ? 71 TYR A CG 1 ATOM 580 C CD1 . TYR A 1 71 ? 4.008 69.907 -22.230 1.00 45.76 ? 71 TYR A CD1 1 ATOM 581 C CD2 . TYR A 1 71 ? 5.657 68.223 -21.841 1.00 48.04 ? 71 TYR A CD2 1 ATOM 582 C CE1 . TYR A 1 71 ? 3.718 69.344 -23.465 1.00 47.25 ? 71 TYR A CE1 1 ATOM 583 C CE2 . TYR A 1 71 ? 5.377 67.651 -23.074 1.00 49.35 ? 71 TYR A CE2 1 ATOM 584 C CZ . TYR A 1 71 ? 4.405 68.216 -23.882 1.00 49.42 ? 71 TYR A CZ 1 ATOM 585 O OH . TYR A 1 71 ? 4.126 67.641 -25.107 1.00 51.49 ? 71 TYR A OH 1 ATOM 586 N N . PRO A 1 72 ? 3.022 71.842 -18.743 1.00 43.71 ? 72 PRO A N 1 ATOM 587 C CA . PRO A 1 72 ? 1.877 72.733 -18.958 1.00 43.17 ? 72 PRO A CA 1 ATOM 588 C C . PRO A 1 72 ? 1.342 72.821 -20.399 1.00 43.27 ? 72 PRO A C 1 ATOM 589 O O . PRO A 1 72 ? 2.078 73.159 -21.335 1.00 42.82 ? 72 PRO A O 1 ATOM 590 C CB . PRO A 1 72 ? 2.376 74.075 -18.405 1.00 42.21 ? 72 PRO A CB 1 ATOM 591 C CG . PRO A 1 72 ? 3.868 73.969 -18.499 1.00 42.35 ? 72 PRO A CG 1 ATOM 592 C CD . PRO A 1 72 ? 4.119 72.556 -18.070 1.00 42.88 ? 72 PRO A CD 1 ATOM 593 N N . THR A 1 73 ? 0.059 72.485 -20.563 1.00 42.51 ? 73 THR A N 1 ATOM 594 C CA . THR A 1 73 ? -0.612 72.526 -21.866 1.00 42.00 ? 73 THR A CA 1 ATOM 595 C C . THR A 1 73 ? -2.081 72.855 -21.655 1.00 42.79 ? 73 THR A C 1 ATOM 596 O O . THR A 1 73 ? -2.887 72.737 -22.571 1.00 44.09 ? 73 THR A O 1 ATOM 597 C CB . THR A 1 73 ? -0.586 71.169 -22.619 1.00 40.63 ? 73 THR A CB 1 ATOM 598 O OG1 . THR A 1 73 ? -1.431 70.234 -21.940 1.00 40.05 ? 73 THR A OG1 1 ATOM 599 C CG2 . THR A 1 73 ? 0.816 70.615 -22.709 1.00 39.07 ? 73 THR A CG2 1 ATOM 600 N N . GLN A 1 74 ? -2.431 73.240 -20.440 1.00 43.50 ? 74 GLN A N 1 ATOM 601 C CA . GLN A 1 74 ? -3.809 73.580 -20.112 1.00 45.46 ? 74 GLN A CA 1 ATOM 602 C C . GLN A 1 74 ? -3.792 74.745 -19.154 1.00 46.87 ? 74 GLN A C 1 ATOM 603 O O . GLN A 1 74 ? -2.737 75.166 -18.692 1.00 48.97 ? 74 GLN A O 1 ATOM 604 C CB . GLN A 1 74 ? -4.511 72.424 -19.401 1.00 45.98 ? 74 GLN A CB 1 ATOM 605 C CG . GLN A 1 74 ? -4.905 71.236 -20.242 1.00 46.84 ? 74 GLN A CG 1 ATOM 606 C CD . GLN A 1 74 ? -5.546 70.154 -19.388 1.00 49.46 ? 74 GLN A CD 1 ATOM 607 O OE1 . GLN A 1 74 ? -6.450 69.449 -19.830 1.00 50.62 ? 74 GLN A OE1 1 ATOM 608 N NE2 . GLN A 1 74 ? -5.069 70.015 -18.152 1.00 51.37 ? 74 GLN A NE2 1 ATOM 609 N N . GLU A 1 75 ? -4.964 75.265 -18.841 1.00 47.59 ? 75 GLU A N 1 ATOM 610 C CA . GLU A 1 75 ? -5.026 76.348 -17.893 1.00 48.85 ? 75 GLU A CA 1 ATOM 611 C C . GLU A 1 75 ? -4.961 75.647 -16.552 1.00 48.96 ? 75 GLU A C 1 ATOM 612 O O . GLU A 1 75 ? -4.481 76.209 -15.572 1.00 49.55 ? 75 GLU A O 1 ATOM 613 C CB . GLU A 1 75 ? -6.335 77.110 -18.049 1.00 50.75 ? 75 GLU A CB 1 ATOM 614 C CG . GLU A 1 75 ? -6.655 78.078 -16.927 1.00 54.34 ? 75 GLU A CG 1 ATOM 615 C CD . GLU A 1 75 ? -7.232 77.383 -15.710 1.00 56.60 ? 75 GLU A CD 1 ATOM 616 O OE1 . GLU A 1 75 ? -7.999 76.407 -15.895 1.00 57.48 ? 75 GLU A OE1 1 ATOM 617 O OE2 . GLU A 1 75 ? -6.932 77.823 -14.575 1.00 57.25 ? 75 GLU A OE2 1 ATOM 618 N N . ALA A 1 76 ? -5.425 74.398 -16.536 1.00 48.79 ? 76 ALA A N 1 ATOM 619 C CA . ALA A 1 76 ? -5.442 73.583 -15.326 1.00 48.55 ? 76 ALA A CA 1 ATOM 620 C C . ALA A 1 76 ? -4.038 73.260 -14.818 1.00 48.77 ? 76 ALA A C 1 ATOM 621 O O . ALA A 1 76 ? -3.879 72.720 -13.723 1.00 48.42 ? 76 ALA A O 1 ATOM 622 C CB . ALA A 1 76 ? -6.214 72.301 -15.574 1.00 48.17 ? 76 ALA A CB 1 ATOM 623 N N . ASP A 1 77 ? -3.022 73.577 -15.614 1.00 48.48 ? 77 ASP A N 1 ATOM 624 C CA . ASP A 1 77 ? -1.645 73.337 -15.208 1.00 48.06 ? 77 ASP A CA 1 ATOM 625 C C . ASP A 1 77 ? -0.718 74.299 -15.938 1.00 47.93 ? 77 ASP A C 1 ATOM 626 O O . ASP A 1 77 ? 0.471 74.031 -16.105 1.00 48.79 ? 77 ASP A O 1 ATOM 627 C CB . ASP A 1 77 ? -1.242 71.881 -15.491 1.00 49.30 ? 77 ASP A CB 1 ATOM 628 C CG . ASP A 1 77 ? -1.117 71.571 -16.978 1.00 50.31 ? 77 ASP A CG 1 ATOM 629 O OD1 . ASP A 1 77 ? -0.970 70.379 -17.320 1.00 50.14 ? 77 ASP A OD1 1 ATOM 630 O OD2 . ASP A 1 77 ? -1.153 72.504 -17.806 1.00 50.67 ? 77 ASP A OD2 1 ATOM 631 N N . SER A 1 78 ? -1.279 75.431 -16.351 1.00 47.40 ? 78 SER A N 1 ATOM 632 C CA . SER A 1 78 ? -0.550 76.458 -17.089 1.00 47.29 ? 78 SER A CA 1 ATOM 633 C C . SER A 1 78 ? 0.770 76.919 -16.470 1.00 47.67 ? 78 SER A C 1 ATOM 634 O O . SER A 1 78 ? 1.714 77.243 -17.194 1.00 46.31 ? 78 SER A O 1 ATOM 635 C CB . SER A 1 78 ? -1.451 77.678 -17.294 1.00 46.41 ? 78 SER A CB 1 ATOM 636 O OG . SER A 1 78 ? -1.808 78.262 -16.053 1.00 44.46 ? 78 SER A OG 1 ATOM 637 N N . LYS A 1 79 ? 0.829 76.940 -15.138 1.00 48.43 ? 79 LYS A N 1 ATOM 638 C CA . LYS A 1 79 ? 2.013 77.398 -14.413 1.00 48.95 ? 79 LYS A CA 1 ATOM 639 C C . LYS A 1 79 ? 3.067 76.362 -14.014 1.00 48.66 ? 79 LYS A C 1 ATOM 640 O O . LYS A 1 79 ? 4.225 76.718 -13.784 1.00 48.20 ? 79 LYS A O 1 ATOM 641 C CB . LYS A 1 79 ? 1.574 78.184 -13.178 1.00 49.65 ? 79 LYS A CB 1 ATOM 642 C CG . LYS A 1 79 ? 1.008 79.546 -13.530 1.00 50.98 ? 79 LYS A CG 1 ATOM 643 C CD . LYS A 1 79 ? 0.465 80.280 -12.324 1.00 53.28 ? 79 LYS A CD 1 ATOM 644 C CE . LYS A 1 79 ? 0.316 81.758 -12.639 1.00 55.24 ? 79 LYS A CE 1 ATOM 645 N NZ . LYS A 1 79 ? -0.422 81.959 -13.917 1.00 57.24 ? 79 LYS A NZ 1 ATOM 646 N N . SER A 1 80 ? 2.675 75.094 -13.928 1.00 48.40 ? 80 SER A N 1 ATOM 647 C CA . SER A 1 80 ? 3.604 74.019 -13.575 1.00 47.26 ? 80 SER A CA 1 ATOM 648 C C . SER A 1 80 ? 2.907 72.687 -13.356 1.00 46.35 ? 80 SER A C 1 ATOM 649 O O . SER A 1 80 ? 1.717 72.635 -13.042 1.00 46.19 ? 80 SER A O 1 ATOM 650 C CB . SER A 1 80 ? 4.399 74.368 -12.316 1.00 47.20 ? 80 SER A CB 1 ATOM 651 O OG . SER A 1 80 ? 5.674 74.873 -12.656 1.00 47.32 ? 80 SER A OG 1 ATOM 652 N N . CYS A 1 81 ? 3.661 71.607 -13.527 1.00 44.47 ? 81 CYS A N 1 ATOM 653 C CA . CYS A 1 81 ? 3.124 70.269 -13.328 1.00 42.41 ? 81 CYS A CA 1 ATOM 654 C C . CYS A 1 81 ? 3.901 69.625 -12.196 1.00 40.89 ? 81 CYS A C 1 ATOM 655 O O . CYS A 1 81 ? 5.048 69.230 -12.365 1.00 40.09 ? 81 CYS A O 1 ATOM 656 C CB . CYS A 1 81 ? 3.265 69.444 -14.605 1.00 42.34 ? 81 CYS A CB 1 ATOM 657 S SG . CYS A 1 81 ? 2.272 70.053 -15.974 1.00 40.33 ? 81 CYS A SG 1 ATOM 658 N N . TRP A 1 82 ? 3.274 69.530 -11.032 1.00 40.06 ? 82 TRP A N 1 ATOM 659 C CA . TRP A 1 82 ? 3.937 68.957 -9.880 1.00 39.88 ? 82 TRP A CA 1 ATOM 660 C C . TRP A 1 82 ? 3.635 67.481 -9.659 1.00 39.87 ? 82 TRP A C 1 ATOM 661 O O . TRP A 1 82 ? 2.896 66.865 -10.419 1.00 40.07 ? 82 TRP A O 1 ATOM 662 C CB . TRP A 1 82 ? 3.634 69.804 -8.641 1.00 39.94 ? 82 TRP A CB 1 ATOM 663 C CG . TRP A 1 82 ? 4.144 71.239 -8.809 1.00 42.10 ? 82 TRP A CG 1 ATOM 664 C CD1 . TRP A 1 82 ? 5.315 71.636 -9.412 1.00 42.77 ? 82 TRP A CD1 1 ATOM 665 C CD2 . TRP A 1 82 ? 3.492 72.444 -8.384 1.00 43.02 ? 82 TRP A CD2 1 ATOM 666 N NE1 . TRP A 1 82 ? 5.422 73.011 -9.390 1.00 41.04 ? 82 TRP A NE1 1 ATOM 667 C CE2 . TRP A 1 82 ? 4.317 73.530 -8.768 1.00 41.55 ? 82 TRP A CE2 1 ATOM 668 C CE3 . TRP A 1 82 ? 2.285 72.715 -7.721 1.00 44.39 ? 82 TRP A CE3 1 ATOM 669 C CZ2 . TRP A 1 82 ? 3.976 74.857 -8.505 1.00 41.50 ? 82 TRP A CZ2 1 ATOM 670 C CZ3 . TRP A 1 82 ? 1.946 74.044 -7.459 1.00 44.21 ? 82 TRP A CZ3 1 ATOM 671 C CH2 . TRP A 1 82 ? 2.790 75.094 -7.855 1.00 43.61 ? 82 TRP A CH2 1 ATOM 672 N N . SER A 1 83 ? 4.230 66.917 -8.619 1.00 40.20 ? 83 SER A N 1 ATOM 673 C CA . SER A 1 83 ? 4.106 65.496 -8.315 1.00 39.56 ? 83 SER A CA 1 ATOM 674 C C . SER A 1 83 ? 2.730 64.854 -8.406 1.00 38.88 ? 83 SER A C 1 ATOM 675 O O . SER A 1 83 ? 1.706 65.505 -8.217 1.00 38.65 ? 83 SER A O 1 ATOM 676 C CB . SER A 1 83 ? 4.733 65.225 -6.951 1.00 39.70 ? 83 SER A CB 1 ATOM 677 O OG . SER A 1 83 ? 6.112 65.567 -6.987 1.00 39.95 ? 83 SER A OG 1 ATOM 678 N N . GLY A 1 84 ? 2.734 63.559 -8.715 1.00 38.39 ? 84 GLY A N 1 ATOM 679 C CA . GLY A 1 84 ? 1.505 62.800 -8.846 1.00 38.55 ? 84 GLY A CA 1 ATOM 680 C C . GLY A 1 84 ? 1.780 61.308 -8.875 1.00 38.28 ? 84 GLY A C 1 ATOM 681 O O . GLY A 1 84 ? 2.902 60.874 -8.636 1.00 37.54 ? 84 GLY A O 1 ATOM 682 N N . SER A 1 85 ? 0.763 60.515 -9.188 1.00 39.08 ? 85 SER A N 1 ATOM 683 C CA . SER A 1 85 ? 0.920 59.067 -9.212 1.00 38.86 ? 85 SER A CA 1 ATOM 684 C C . SER A 1 85 ? 0.209 58.367 -10.375 1.00 38.11 ? 85 SER A C 1 ATOM 685 O O . SER A 1 85 ? -0.838 58.816 -10.856 1.00 37.35 ? 85 SER A O 1 ATOM 686 C CB . SER A 1 85 ? 0.426 58.490 -7.884 1.00 40.41 ? 85 SER A CB 1 ATOM 687 O OG . SER A 1 85 ? 0.929 59.249 -6.797 1.00 40.28 ? 85 SER A OG 1 ATOM 688 N N . ALA A 1 86 ? 0.788 57.249 -10.807 1.00 36.84 ? 86 ALA A N 1 ATOM 689 C CA . ALA A 1 86 ? 0.244 56.464 -11.906 1.00 35.23 ? 86 ALA A CA 1 ATOM 690 C C . ALA A 1 86 ? -0.586 55.273 -11.413 1.00 35.12 ? 86 ALA A C 1 ATOM 691 O O . ALA A 1 86 ? -0.126 54.476 -10.592 1.00 34.78 ? 86 ALA A O 1 ATOM 692 C CB . ALA A 1 86 ? 1.378 55.978 -12.785 1.00 33.91 ? 86 ALA A CB 1 ATOM 693 N N . THR A 1 87 ? -1.811 55.167 -11.922 1.00 34.70 ? 87 THR A N 1 ATOM 694 C CA . THR A 1 87 ? -2.713 54.078 -11.577 1.00 35.15 ? 87 THR A CA 1 ATOM 695 C C . THR A 1 87 ? -3.115 53.414 -12.881 1.00 36.56 ? 87 THR A C 1 ATOM 696 O O . THR A 1 87 ? -3.510 54.097 -13.827 1.00 37.63 ? 87 THR A O 1 ATOM 697 C CB . THR A 1 87 ? -3.996 54.581 -10.919 1.00 35.95 ? 87 THR A CB 1 ATOM 698 O OG1 . THR A 1 87 ? -3.665 55.401 -9.794 1.00 39.20 ? 87 THR A OG1 1 ATOM 699 C CG2 . THR A 1 87 ? -4.854 53.403 -10.465 1.00 35.32 ? 87 THR A CG2 1 ATOM 700 N N . ILE A 1 88 ? -3.014 52.088 -12.941 1.00 36.85 ? 88 ILE A N 1 ATOM 701 C CA . ILE A 1 88 ? -3.384 51.361 -14.150 1.00 35.32 ? 88 ILE A CA 1 ATOM 702 C C . ILE A 1 88 ? -4.777 50.780 -13.965 1.00 36.82 ? 88 ILE A C 1 ATOM 703 O O . ILE A 1 88 ? -4.958 49.786 -13.257 1.00 36.88 ? 88 ILE A O 1 ATOM 704 C CB . ILE A 1 88 ? -2.377 50.249 -14.438 1.00 32.22 ? 88 ILE A CB 1 ATOM 705 C CG1 . ILE A 1 88 ? -0.981 50.862 -14.562 1.00 31.23 ? 88 ILE A CG1 1 ATOM 706 C CG2 . ILE A 1 88 ? -2.744 49.540 -15.721 1.00 33.05 ? 88 ILE A CG2 1 ATOM 707 C CD1 . ILE A 1 88 ? 0.105 49.891 -14.911 1.00 29.72 ? 88 ILE A CD1 1 ATOM 708 N N . LEU A 1 89 ? -5.757 51.419 -14.604 1.00 37.37 ? 89 LEU A N 1 ATOM 709 C CA . LEU A 1 89 ? -7.159 51.019 -14.502 1.00 37.64 ? 89 LEU A CA 1 ATOM 710 C C . LEU A 1 89 ? -7.464 49.762 -15.271 1.00 37.89 ? 89 LEU A C 1 ATOM 711 O O . LEU A 1 89 ? -6.710 49.375 -16.152 1.00 37.15 ? 89 LEU A O 1 ATOM 712 C CB . LEU A 1 89 ? -8.067 52.112 -15.055 1.00 38.01 ? 89 LEU A CB 1 ATOM 713 C CG . LEU A 1 89 ? -7.689 53.553 -14.749 1.00 39.40 ? 89 LEU A CG 1 ATOM 714 C CD1 . LEU A 1 89 ? -8.686 54.484 -15.408 1.00 39.41 ? 89 LEU A CD1 1 ATOM 715 C CD2 . LEU A 1 89 ? -7.659 53.761 -13.243 1.00 42.23 ? 89 LEU A CD2 1 ATOM 716 N N . PRO A 1 90 ? -8.587 49.103 -14.942 1.00 39.40 ? 90 PRO A N 1 ATOM 717 C CA . PRO A 1 90 ? -9.000 47.877 -15.630 1.00 39.59 ? 90 PRO A CA 1 ATOM 718 C C . PRO A 1 90 ? -9.161 48.230 -17.107 1.00 40.16 ? 90 PRO A C 1 ATOM 719 O O . PRO A 1 90 ? -9.713 49.283 -17.443 1.00 40.41 ? 90 PRO A O 1 ATOM 720 C CB . PRO A 1 90 ? -10.330 47.546 -14.964 1.00 39.36 ? 90 PRO A CB 1 ATOM 721 C CG . PRO A 1 90 ? -10.122 48.033 -13.570 1.00 39.08 ? 90 PRO A CG 1 ATOM 722 C CD . PRO A 1 90 ? -9.463 49.375 -13.789 1.00 39.28 ? 90 PRO A CD 1 ATOM 723 N N . GLY A 1 91 ? -8.685 47.357 -17.984 1.00 40.29 ? 91 GLY A N 1 ATOM 724 C CA . GLY A 1 91 ? -8.754 47.655 -19.399 1.00 42.69 ? 91 GLY A CA 1 ATOM 725 C C . GLY A 1 91 ? -7.330 47.987 -19.793 1.00 43.94 ? 91 GLY A C 1 ATOM 726 O O . GLY A 1 91 ? -7.018 48.304 -20.945 1.00 45.66 ? 91 GLY A O 1 ATOM 727 N N . ASN A 1 92 ? -6.470 47.930 -18.783 1.00 44.17 ? 92 ASN A N 1 ATOM 728 C CA . ASN A 1 92 ? -5.044 48.161 -18.920 1.00 42.72 ? 92 ASN A CA 1 ATOM 729 C C . ASN A 1 92 ? -4.626 49.508 -19.503 1.00 41.36 ? 92 ASN A C 1 ATOM 730 O O . ASN A 1 92 ? -3.839 49.579 -20.446 1.00 39.38 ? 92 ASN A O 1 ATOM 731 C CB . ASN A 1 92 ? -4.448 47.019 -19.732 1.00 43.80 ? 92 ASN A CB 1 ATOM 732 C CG . ASN A 1 92 ? -2.963 46.963 -19.617 1.00 46.12 ? 92 ASN A CG 1 ATOM 733 O OD1 . ASN A 1 92 ? -2.412 47.039 -18.516 1.00 46.15 ? 92 ASN A OD1 1 ATOM 734 N ND2 . ASN A 1 92 ? -2.289 46.828 -20.751 1.00 48.99 ? 92 ASN A ND2 1 ATOM 735 N N . ILE A 1 93 ? -5.146 50.579 -18.918 1.00 41.68 ? 93 ILE A N 1 ATOM 736 C CA . ILE A 1 93 ? -4.831 51.933 -19.360 1.00 42.53 ? 93 ILE A CA 1 ATOM 737 C C . ILE A 1 93 ? -4.276 52.776 -18.198 1.00 41.97 ? 93 ILE A C 1 ATOM 738 O O . ILE A 1 93 ? -4.988 53.085 -17.238 1.00 42.17 ? 93 ILE A O 1 ATOM 739 C CB . ILE A 1 93 ? -6.084 52.612 -19.934 1.00 43.73 ? 93 ILE A CB 1 ATOM 740 C CG1 . ILE A 1 93 ? -5.847 54.116 -20.074 1.00 45.62 ? 93 ILE A CG1 1 ATOM 741 C CG2 . ILE A 1 93 ? -7.274 52.313 -19.057 1.00 44.82 ? 93 ILE A CG2 1 ATOM 742 C CD1 . ILE A 1 93 ? -4.765 54.471 -21.072 1.00 48.73 ? 93 ILE A CD1 1 ATOM 743 N N . PRO A 1 94 ? -2.992 53.162 -18.279 1.00 40.68 ? 94 PRO A N 1 ATOM 744 C CA . PRO A 1 94 ? -2.366 53.960 -17.225 1.00 39.30 ? 94 PRO A CA 1 ATOM 745 C C . PRO A 1 94 ? -3.002 55.330 -17.122 1.00 39.55 ? 94 PRO A C 1 ATOM 746 O O . PRO A 1 94 ? -3.082 56.052 -18.114 1.00 40.89 ? 94 PRO A O 1 ATOM 747 C CB . PRO A 1 94 ? -0.912 54.061 -17.678 1.00 38.21 ? 94 PRO A CB 1 ATOM 748 C CG . PRO A 1 94 ? -0.738 52.897 -18.589 1.00 38.97 ? 94 PRO A CG 1 ATOM 749 C CD . PRO A 1 94 ? -2.024 52.877 -19.348 1.00 39.79 ? 94 PRO A CD 1 ATOM 750 N N . ALA A 1 95 ? -3.459 55.684 -15.926 1.00 39.16 ? 95 ALA A N 1 ATOM 751 C CA . ALA A 1 95 ? -4.066 56.992 -15.694 1.00 39.01 ? 95 ALA A CA 1 ATOM 752 C C . ALA A 1 95 ? -3.141 57.752 -14.747 1.00 38.69 ? 95 ALA A C 1 ATOM 753 O O . ALA A 1 95 ? -2.764 57.241 -13.692 1.00 39.12 ? 95 ALA A O 1 ATOM 754 C CB . ALA A 1 95 ? -5.456 56.833 -15.073 1.00 38.01 ? 95 ALA A CB 1 ATOM 755 N N . MET A 1 96 ? -2.770 58.968 -15.119 1.00 37.68 ? 96 MET A N 1 ATOM 756 C CA . MET A 1 96 ? -1.865 59.747 -14.289 1.00 37.53 ? 96 MET A CA 1 ATOM 757 C C . MET A 1 96 ? -2.563 60.916 -13.594 1.00 37.96 ? 96 MET A C 1 ATOM 758 O O . MET A 1 96 ? -3.090 61.811 -14.245 1.00 39.82 ? 96 MET A O 1 ATOM 759 C CB . MET A 1 96 ? -0.717 60.275 -15.150 1.00 37.22 ? 96 MET A CB 1 ATOM 760 C CG . MET A 1 96 ? 0.564 60.550 -14.393 1.00 38.03 ? 96 MET A CG 1 ATOM 761 S SD . MET A 1 96 ? 1.479 59.047 -13.955 1.00 40.07 ? 96 MET A SD 1 ATOM 762 C CE . MET A 1 96 ? 2.445 58.780 -15.438 1.00 37.18 ? 96 MET A CE 1 ATOM 763 N N . LEU A 1 97 ? -2.572 60.897 -12.267 1.00 37.77 ? 97 LEU A N 1 ATOM 764 C CA . LEU A 1 97 ? -3.181 61.969 -11.485 1.00 36.74 ? 97 LEU A CA 1 ATOM 765 C C . LEU A 1 97 ? -2.033 62.813 -10.925 1.00 38.69 ? 97 LEU A C 1 ATOM 766 O O . LEU A 1 97 ? -1.105 62.278 -10.324 1.00 39.49 ? 97 LEU A O 1 ATOM 767 C CB . LEU A 1 97 ? -4.012 61.374 -10.346 1.00 34.24 ? 97 LEU A CB 1 ATOM 768 C CG . LEU A 1 97 ? -5.537 61.532 -10.386 1.00 32.89 ? 97 LEU A CG 1 ATOM 769 C CD1 . LEU A 1 97 ? -6.042 61.251 -11.770 1.00 33.69 ? 97 LEU A CD1 1 ATOM 770 C CD2 . LEU A 1 97 ? -6.194 60.593 -9.382 1.00 31.74 ? 97 LEU A CD2 1 ATOM 771 N N . TYR A 1 98 ? -2.075 64.126 -11.129 1.00 39.78 ? 98 TYR A N 1 ATOM 772 C CA . TYR A 1 98 ? -1.001 64.984 -10.636 1.00 40.15 ? 98 TYR A CA 1 ATOM 773 C C . TYR A 1 98 ? -1.500 66.365 -10.245 1.00 40.12 ? 98 TYR A C 1 ATOM 774 O O . TYR A 1 98 ? -2.598 66.766 -10.613 1.00 40.29 ? 98 TYR A O 1 ATOM 775 C CB . TYR A 1 98 ? 0.076 65.117 -11.709 1.00 41.62 ? 98 TYR A CB 1 ATOM 776 C CG . TYR A 1 98 ? -0.379 65.895 -12.911 1.00 43.86 ? 98 TYR A CG 1 ATOM 777 C CD1 . TYR A 1 98 ? -0.058 67.242 -13.055 1.00 45.20 ? 98 TYR A CD1 1 ATOM 778 C CD2 . TYR A 1 98 ? -1.160 65.294 -13.892 1.00 45.32 ? 98 TYR A CD2 1 ATOM 779 C CE1 . TYR A 1 98 ? -0.505 67.976 -14.153 1.00 47.79 ? 98 TYR A CE1 1 ATOM 780 C CE2 . TYR A 1 98 ? -1.616 66.012 -14.993 1.00 47.37 ? 98 TYR A CE2 1 ATOM 781 C CZ . TYR A 1 98 ? -1.288 67.352 -15.120 1.00 48.79 ? 98 TYR A CZ 1 ATOM 782 O OH . TYR A 1 98 ? -1.753 68.066 -16.209 1.00 49.74 ? 98 TYR A OH 1 ATOM 783 N N . THR A 1 99 ? -0.685 67.096 -9.496 1.00 40.93 ? 99 THR A N 1 ATOM 784 C CA . THR A 1 99 ? -1.053 68.439 -9.062 1.00 41.02 ? 99 THR A CA 1 ATOM 785 C C . THR A 1 99 ? -0.527 69.471 -10.035 1.00 42.54 ? 99 THR A C 1 ATOM 786 O O . THR A 1 99 ? 0.665 69.502 -10.333 1.00 43.97 ? 99 THR A O 1 ATOM 787 C CB . THR A 1 99 ? -0.472 68.783 -7.682 1.00 39.55 ? 99 THR A CB 1 ATOM 788 O OG1 . THR A 1 99 ? -1.108 67.981 -6.681 1.00 38.49 ? 99 THR A OG1 1 ATOM 789 C CG2 . THR A 1 99 ? -0.666 70.270 -7.377 1.00 36.66 ? 99 THR A CG2 1 ATOM 790 N N . GLY A 1 100 ? -1.418 70.325 -10.519 1.00 43.32 ? 100 GLY A N 1 ATOM 791 C CA . GLY A 1 100 ? -1.003 71.359 -11.441 1.00 44.06 ? 100 GLY A CA 1 ATOM 792 C C . GLY A 1 100 ? -1.127 72.715 -10.781 1.00 45.21 ? 100 GLY A C 1 ATOM 793 O O . GLY A 1 100 ? -1.817 72.859 -9.769 1.00 45.27 ? 100 GLY A O 1 ATOM 794 N N . SER A 1 101 ? -0.435 73.702 -11.339 1.00 45.89 ? 101 SER A N 1 ATOM 795 C CA . SER A 1 101 ? -0.494 75.065 -10.836 1.00 46.79 ? 101 SER A CA 1 ATOM 796 C C . SER A 1 101 ? -1.234 75.800 -11.951 1.00 48.08 ? 101 SER A C 1 ATOM 797 O O . SER A 1 101 ? -0.658 76.065 -13.005 1.00 47.24 ? 101 SER A O 1 ATOM 798 C CB . SER A 1 101 ? 0.924 75.623 -10.657 1.00 46.29 ? 101 SER A CB 1 ATOM 799 O OG . SER A 1 101 ? 0.912 76.880 -9.999 1.00 46.34 ? 101 SER A OG 1 ATOM 800 N N . ASP A 1 102 ? -2.511 76.104 -11.738 1.00 50.03 ? 102 ASP A N 1 ATOM 801 C CA . ASP A 1 102 ? -3.276 76.776 -12.778 1.00 53.60 ? 102 ASP A CA 1 ATOM 802 C C . ASP A 1 102 ? -3.062 78.284 -12.855 1.00 56.24 ? 102 ASP A C 1 ATOM 803 O O . ASP A 1 102 ? -2.392 78.880 -12.009 1.00 57.31 ? 102 ASP A O 1 ATOM 804 C CB . ASP A 1 102 ? -4.771 76.491 -12.634 1.00 53.63 ? 102 ASP A CB 1 ATOM 805 C CG . ASP A 1 102 ? -5.389 77.184 -11.442 1.00 54.52 ? 102 ASP A CG 1 ATOM 806 O OD1 . ASP A 1 102 ? -4.867 78.240 -11.023 1.00 53.04 ? 102 ASP A OD1 1 ATOM 807 O OD2 . ASP A 1 102 ? -6.415 76.675 -10.935 1.00 54.93 ? 102 ASP A OD2 1 ATOM 808 N N . SER A 1 103 ? -3.652 78.880 -13.889 1.00 58.24 ? 103 SER A N 1 ATOM 809 C CA . SER A 1 103 ? -3.569 80.310 -14.160 1.00 60.09 ? 103 SER A CA 1 ATOM 810 C C . SER A 1 103 ? -3.582 81.187 -12.909 1.00 62.09 ? 103 SER A C 1 ATOM 811 O O . SER A 1 103 ? -2.747 82.086 -12.761 1.00 62.07 ? 103 SER A O 1 ATOM 812 C CB . SER A 1 103 ? -4.724 80.704 -15.067 1.00 59.57 ? 103 SER A CB 1 ATOM 813 O OG . SER A 1 103 ? -5.941 80.215 -14.529 1.00 59.51 ? 103 SER A OG 1 ATOM 814 N N . LYS A 1 104 ? -4.537 80.934 -12.018 1.00 63.76 ? 104 LYS A N 1 ATOM 815 C CA . LYS A 1 104 ? -4.650 81.705 -10.783 1.00 65.19 ? 104 LYS A CA 1 ATOM 816 C C . LYS A 1 104 ? -3.845 81.072 -9.645 1.00 64.91 ? 104 LYS A C 1 ATOM 817 O O . LYS A 1 104 ? -4.224 81.129 -8.470 1.00 64.98 ? 104 LYS A O 1 ATOM 818 C CB . LYS A 1 104 ? -6.127 81.859 -10.401 1.00 66.50 ? 104 LYS A CB 1 ATOM 819 C CG . LYS A 1 104 ? -6.953 80.628 -10.670 1.00 69.50 ? 104 LYS A CG 1 ATOM 820 C CD . LYS A 1 104 ? -8.398 80.985 -10.956 1.00 71.91 ? 104 LYS A CD 1 ATOM 821 C CE . LYS A 1 104 ? -9.153 79.786 -11.539 1.00 74.30 ? 104 LYS A CE 1 ATOM 822 N NZ . LYS A 1 104 ? -8.587 79.294 -12.841 1.00 73.97 ? 104 LYS A NZ 1 ATOM 823 N N . SER A 1 105 ? -2.721 80.475 -10.024 1.00 63.91 ? 105 SER A N 1 ATOM 824 C CA . SER A 1 105 ? -1.804 79.837 -9.097 1.00 63.18 ? 105 SER A CA 1 ATOM 825 C C . SER A 1 105 ? -2.405 79.015 -7.969 1.00 63.06 ? 105 SER A C 1 ATOM 826 O O . SER A 1 105 ? -1.958 79.108 -6.829 1.00 64.55 ? 105 SER A O 1 ATOM 827 C CB . SER A 1 105 ? -0.875 80.886 -8.508 1.00 62.50 ? 105 SER A CB 1 ATOM 828 O OG . SER A 1 105 ? -0.009 81.371 -9.510 1.00 63.97 ? 105 SER A OG 1 ATOM 829 N N . ARG A 1 106 ? -3.418 78.216 -8.274 1.00 61.77 ? 106 ARG A N 1 ATOM 830 C CA . ARG A 1 106 ? -4.010 77.358 -7.261 1.00 60.09 ? 106 ARG A CA 1 ATOM 831 C C . ARG A 1 106 ? -3.374 75.998 -7.483 1.00 59.30 ? 106 ARG A C 1 ATOM 832 O O . ARG A 1 106 ? -2.770 75.751 -8.529 1.00 59.33 ? 106 ARG A O 1 ATOM 833 C CB . ARG A 1 106 ? -5.510 77.205 -7.464 1.00 60.71 ? 106 ARG A CB 1 ATOM 834 C CG . ARG A 1 106 ? -6.328 78.450 -7.341 1.00 63.13 ? 106 ARG A CG 1 ATOM 835 C CD . ARG A 1 106 ? -7.786 78.074 -7.527 1.00 65.71 ? 106 ARG A CD 1 ATOM 836 N NE . ARG A 1 106 ? -8.022 77.522 -8.861 1.00 67.82 ? 106 ARG A NE 1 ATOM 837 C CZ . ARG A 1 106 ? -9.102 76.825 -9.210 1.00 69.14 ? 106 ARG A CZ 1 ATOM 838 N NH1 . ARG A 1 106 ? -10.058 76.583 -8.317 1.00 68.17 ? 106 ARG A NH1 1 ATOM 839 N NH2 . ARG A 1 106 ? -9.227 76.374 -10.457 1.00 69.83 ? 106 ARG A NH2 1 ATOM 840 N N . GLN A 1 107 ? -3.501 75.116 -6.501 1.00 57.42 ? 107 GLN A N 1 ATOM 841 C CA . GLN A 1 107 ? -2.970 73.778 -6.651 1.00 55.45 ? 107 GLN A CA 1 ATOM 842 C C . GLN A 1 107 ? -4.187 72.901 -6.925 1.00 54.00 ? 107 GLN A C 1 ATOM 843 O O . GLN A 1 107 ? -5.064 72.754 -6.073 1.00 53.74 ? 107 GLN A O 1 ATOM 844 C CB . GLN A 1 107 ? -2.244 73.328 -5.378 1.00 56.22 ? 107 GLN A CB 1 ATOM 845 C CG . GLN A 1 107 ? -1.031 74.178 -5.015 1.00 57.73 ? 107 GLN A CG 1 ATOM 846 C CD . GLN A 1 107 ? -0.138 73.520 -3.971 1.00 59.21 ? 107 GLN A CD 1 ATOM 847 O OE1 . GLN A 1 107 ? -0.619 72.961 -2.984 1.00 59.92 ? 107 GLN A OE1 1 ATOM 848 N NE2 . GLN A 1 107 ? 1.171 73.595 -4.181 1.00 59.94 ? 107 GLN A NE2 1 ATOM 849 N N . VAL A 1 108 ? -4.252 72.340 -8.126 1.00 52.36 ? 108 VAL A N 1 ATOM 850 C CA . VAL A 1 108 ? -5.380 71.498 -8.501 1.00 51.13 ? 108 VAL A CA 1 ATOM 851 C C . VAL A 1 108 ? -4.976 70.109 -8.998 1.00 50.20 ? 108 VAL A C 1 ATOM 852 O O . VAL A 1 108 ? -3.852 69.898 -9.453 1.00 50.57 ? 108 VAL A O 1 ATOM 853 C CB . VAL A 1 108 ? -6.239 72.193 -9.582 1.00 50.88 ? 108 VAL A CB 1 ATOM 854 C CG1 . VAL A 1 108 ? -6.869 73.442 -9.011 1.00 49.80 ? 108 VAL A CG1 1 ATOM 855 C CG2 . VAL A 1 108 ? -5.384 72.549 -10.784 1.00 49.73 ? 108 VAL A CG2 1 ATOM 856 N N . GLN A 1 109 ? -5.906 69.165 -8.905 1.00 47.88 ? 109 GLN A N 1 ATOM 857 C CA . GLN A 1 109 ? -5.666 67.797 -9.335 1.00 46.61 ? 109 GLN A CA 1 ATOM 858 C C . GLN A 1 109 ? -6.118 67.572 -10.768 1.00 46.23 ? 109 GLN A C 1 ATOM 859 O O . GLN A 1 109 ? -7.292 67.746 -11.083 1.00 48.11 ? 109 GLN A O 1 ATOM 860 C CB . GLN A 1 109 ? -6.399 66.841 -8.402 1.00 46.84 ? 109 GLN A CB 1 ATOM 861 C CG . GLN A 1 109 ? -5.593 66.462 -7.176 1.00 49.51 ? 109 GLN A CG 1 ATOM 862 C CD . GLN A 1 109 ? -4.712 67.594 -6.680 1.00 50.49 ? 109 GLN A CD 1 ATOM 863 O OE1 . GLN A 1 109 ? -5.195 68.595 -6.151 1.00 51.58 ? 109 GLN A OE1 1 ATOM 864 N NE2 . GLN A 1 109 ? -3.407 67.439 -6.859 1.00 50.06 ? 109 GLN A NE2 1 ATOM 865 N N . ASP A 1 110 ? -5.181 67.167 -11.625 1.00 44.33 ? 110 ASP A N 1 ATOM 866 C CA . ASP A 1 110 ? -5.448 66.920 -13.045 1.00 41.78 ? 110 ASP A CA 1 ATOM 867 C C . ASP A 1 110 ? -5.300 65.451 -13.459 1.00 40.81 ? 110 ASP A C 1 ATOM 868 O O . ASP A 1 110 ? -4.680 64.650 -12.763 1.00 41.01 ? 110 ASP A O 1 ATOM 869 C CB . ASP A 1 110 ? -4.503 67.768 -13.896 1.00 41.42 ? 110 ASP A CB 1 ATOM 870 C CG . ASP A 1 110 ? -4.703 69.259 -13.686 1.00 41.43 ? 110 ASP A CG 1 ATOM 871 O OD1 . ASP A 1 110 ? -3.724 70.016 -13.851 1.00 41.37 ? 110 ASP A OD1 1 ATOM 872 O OD2 . ASP A 1 110 ? -5.836 69.675 -13.372 1.00 40.65 ? 110 ASP A OD2 1 ATOM 873 N N . LEU A 1 111 ? -5.869 65.116 -14.611 1.00 40.14 ? 111 LEU A N 1 ATOM 874 C CA . LEU A 1 111 ? -5.815 63.761 -15.152 1.00 38.88 ? 111 LEU A CA 1 ATOM 875 C C . LEU A 1 111 ? -5.041 63.791 -16.477 1.00 39.51 ? 111 LEU A C 1 ATOM 876 O O . LEU A 1 111 ? -5.001 64.814 -17.157 1.00 40.46 ? 111 LEU A O 1 ATOM 877 C CB . LEU A 1 111 ? -7.232 63.248 -15.410 1.00 36.86 ? 111 LEU A CB 1 ATOM 878 C CG . LEU A 1 111 ? -7.531 61.756 -15.280 1.00 35.81 ? 111 LEU A CG 1 ATOM 879 C CD1 . LEU A 1 111 ? -8.667 61.421 -16.230 1.00 34.17 ? 111 LEU A CD1 1 ATOM 880 C CD2 . LEU A 1 111 ? -6.303 60.909 -15.597 1.00 34.50 ? 111 LEU A CD2 1 ATOM 881 N N . ALA A 1 112 ? -4.427 62.671 -16.838 1.00 39.49 ? 112 ALA A N 1 ATOM 882 C CA . ALA A 1 112 ? -3.669 62.567 -18.080 1.00 39.06 ? 112 ALA A CA 1 ATOM 883 C C . ALA A 1 112 ? -3.407 61.083 -18.320 1.00 40.49 ? 112 ALA A C 1 ATOM 884 O O . ALA A 1 112 ? -3.246 60.316 -17.371 1.00 41.63 ? 112 ALA A O 1 ATOM 885 C CB . ALA A 1 112 ? -2.356 63.324 -17.954 1.00 35.73 ? 112 ALA A CB 1 ATOM 886 N N . TRP A 1 113 ? -3.400 60.657 -19.574 1.00 40.85 ? 113 TRP A N 1 ATOM 887 C CA . TRP A 1 113 ? -3.123 59.255 -19.856 1.00 42.57 ? 113 TRP A CA 1 ATOM 888 C C . TRP A 1 113 ? -2.409 59.166 -21.196 1.00 43.68 ? 113 TRP A C 1 ATOM 889 O O . TRP A 1 113 ? -2.456 60.105 -21.991 1.00 44.45 ? 113 TRP A O 1 ATOM 890 C CB . TRP A 1 113 ? -4.416 58.429 -19.830 1.00 42.84 ? 113 TRP A CB 1 ATOM 891 C CG . TRP A 1 113 ? -5.386 58.744 -20.899 1.00 44.81 ? 113 TRP A CG 1 ATOM 892 C CD1 . TRP A 1 113 ? -5.478 58.147 -22.114 1.00 45.16 ? 113 TRP A CD1 1 ATOM 893 C CD2 . TRP A 1 113 ? -6.385 59.769 -20.877 1.00 46.37 ? 113 TRP A CD2 1 ATOM 894 N NE1 . TRP A 1 113 ? -6.473 58.734 -22.858 1.00 45.82 ? 113 TRP A NE1 1 ATOM 895 C CE2 . TRP A 1 113 ? -7.049 59.735 -22.120 1.00 45.89 ? 113 TRP A CE2 1 ATOM 896 C CE3 . TRP A 1 113 ? -6.791 60.714 -19.922 1.00 47.83 ? 113 TRP A CE3 1 ATOM 897 C CZ2 . TRP A 1 113 ? -8.088 60.615 -22.445 1.00 45.87 ? 113 TRP A CZ2 1 ATOM 898 C CZ3 . TRP A 1 113 ? -7.832 61.595 -20.245 1.00 48.15 ? 113 TRP A CZ3 1 ATOM 899 C CH2 . TRP A 1 113 ? -8.467 61.532 -21.496 1.00 46.93 ? 113 TRP A CH2 1 ATOM 900 N N . PRO A 1 114 ? -1.708 58.053 -21.456 1.00 43.84 ? 114 PRO A N 1 ATOM 901 C CA . PRO A 1 114 ? -1.003 57.945 -22.736 1.00 45.29 ? 114 PRO A CA 1 ATOM 902 C C . PRO A 1 114 ? -1.888 58.108 -23.970 1.00 47.27 ? 114 PRO A C 1 ATOM 903 O O . PRO A 1 114 ? -2.959 57.507 -24.073 1.00 47.50 ? 114 PRO A O 1 ATOM 904 C CB . PRO A 1 114 ? -0.329 56.577 -22.646 1.00 43.53 ? 114 PRO A CB 1 ATOM 905 C CG . PRO A 1 114 ? -1.220 55.820 -21.740 1.00 43.57 ? 114 PRO A CG 1 ATOM 906 C CD . PRO A 1 114 ? -1.580 56.814 -20.677 1.00 42.37 ? 114 PRO A CD 1 ATOM 907 N N . LYS A 1 115 ? -1.421 58.946 -24.893 1.00 49.02 ? 115 LYS A N 1 ATOM 908 C CA . LYS A 1 115 ? -2.115 59.247 -26.143 1.00 50.13 ? 115 LYS A CA 1 ATOM 909 C C . LYS A 1 115 ? -1.927 58.119 -27.165 1.00 51.20 ? 115 LYS A C 1 ATOM 910 O O . LYS A 1 115 ? -2.829 57.816 -27.947 1.00 50.40 ? 115 LYS A O 1 ATOM 911 C CB . LYS A 1 115 ? -1.567 60.565 -26.709 1.00 49.94 ? 115 LYS A CB 1 ATOM 912 C CG . LYS A 1 115 ? -2.212 61.029 -27.988 1.00 50.39 ? 115 LYS A CG 1 ATOM 913 C CD . LYS A 1 115 ? -1.619 62.345 -28.436 1.00 51.32 ? 115 LYS A CD 1 ATOM 914 C CE . LYS A 1 115 ? -2.345 62.890 -29.656 1.00 52.22 ? 115 LYS A CE 1 ATOM 915 N NZ . LYS A 1 115 ? -1.771 64.187 -30.126 1.00 52.48 ? 115 LYS A NZ 1 ATOM 916 N N . ASN A 1 116 ? -0.747 57.500 -27.131 1.00 53.04 ? 116 ASN A N 1 ATOM 917 C CA . ASN A 1 116 ? -0.375 56.412 -28.040 1.00 53.62 ? 116 ASN A CA 1 ATOM 918 C C . ASN A 1 116 ? -0.099 55.169 -27.196 1.00 51.54 ? 116 ASN A C 1 ATOM 919 O O . ASN A 1 116 ? 1.051 54.856 -26.892 1.00 52.38 ? 116 ASN A O 1 ATOM 920 C CB . ASN A 1 116 ? 0.894 56.806 -28.797 1.00 57.98 ? 116 ASN A CB 1 ATOM 921 C CG . ASN A 1 116 ? 1.061 56.062 -30.106 1.00 61.56 ? 116 ASN A CG 1 ATOM 922 O OD1 . ASN A 1 116 ? 0.940 54.835 -30.148 1.00 59.37 ? 116 ASN A OD1 1 ATOM 923 N ND2 . ASN A 1 116 ? 1.368 56.812 -31.171 1.00 66.88 ? 116 ASN A ND2 1 ATOM 924 N N . LEU A 1 117 ? -1.158 54.462 -26.827 1.00 48.29 ? 117 LEU A N 1 ATOM 925 C CA . LEU A 1 117 ? -1.035 53.282 -25.983 1.00 45.19 ? 117 LEU A CA 1 ATOM 926 C C . LEU A 1 117 ? -0.307 52.109 -26.640 1.00 43.96 ? 117 LEU A C 1 ATOM 927 O O . LEU A 1 117 ? -0.146 51.062 -26.027 1.00 43.26 ? 117 LEU A O 1 ATOM 928 C CB . LEU A 1 117 ? -2.429 52.850 -25.529 1.00 43.67 ? 117 LEU A CB 1 ATOM 929 C CG . LEU A 1 117 ? -2.568 52.089 -24.216 1.00 41.55 ? 117 LEU A CG 1 ATOM 930 C CD1 . LEU A 1 117 ? -1.889 52.834 -23.090 1.00 40.22 ? 117 LEU A CD1 1 ATOM 931 C CD2 . LEU A 1 117 ? -4.041 51.924 -23.921 1.00 42.22 ? 117 LEU A CD2 1 ATOM 932 N N . SER A 1 118 ? 0.136 52.285 -27.880 1.00 43.86 ? 118 SER A N 1 ATOM 933 C CA . SER A 1 118 ? 0.844 51.223 -28.593 1.00 43.90 ? 118 SER A CA 1 ATOM 934 C C . SER A 1 118 ? 2.331 51.554 -28.695 1.00 44.11 ? 118 SER A C 1 ATOM 935 O O . SER A 1 118 ? 3.087 50.900 -29.417 1.00 44.92 ? 118 SER A O 1 ATOM 936 C CB . SER A 1 118 ? 0.265 51.031 -29.996 1.00 44.09 ? 118 SER A CB 1 ATOM 937 O OG . SER A 1 118 ? 0.533 52.164 -30.803 1.00 48.07 ? 118 SER A OG 1 ATOM 938 N N . ASP A 1 119 ? 2.736 52.598 -27.987 1.00 42.87 ? 119 ASP A N 1 ATOM 939 C CA . ASP A 1 119 ? 4.128 52.991 -27.953 1.00 40.25 ? 119 ASP A CA 1 ATOM 940 C C . ASP A 1 119 ? 4.655 52.374 -26.665 1.00 39.51 ? 119 ASP A C 1 ATOM 941 O O . ASP A 1 119 ? 4.243 52.758 -25.570 1.00 40.83 ? 119 ASP A O 1 ATOM 942 C CB . ASP A 1 119 ? 4.241 54.506 -27.907 1.00 39.96 ? 119 ASP A CB 1 ATOM 943 C CG . ASP A 1 119 ? 5.626 54.965 -27.539 1.00 41.19 ? 119 ASP A CG 1 ATOM 944 O OD1 . ASP A 1 119 ? 6.578 54.165 -27.693 1.00 40.54 ? 119 ASP A OD1 1 ATOM 945 O OD2 . ASP A 1 119 ? 5.756 56.127 -27.107 1.00 42.94 ? 119 ASP A OD2 1 ATOM 946 N N . PRO A 1 120 ? 5.564 51.399 -26.777 1.00 37.34 ? 120 PRO A N 1 ATOM 947 C CA . PRO A 1 120 ? 6.133 50.727 -25.604 1.00 36.19 ? 120 PRO A CA 1 ATOM 948 C C . PRO A 1 120 ? 6.650 51.699 -24.556 1.00 36.26 ? 120 PRO A C 1 ATOM 949 O O . PRO A 1 120 ? 6.627 51.417 -23.354 1.00 36.35 ? 120 PRO A O 1 ATOM 950 C CB . PRO A 1 120 ? 7.256 49.886 -26.195 1.00 34.02 ? 120 PRO A CB 1 ATOM 951 C CG . PRO A 1 120 ? 6.795 49.642 -27.592 1.00 35.55 ? 120 PRO A CG 1 ATOM 952 C CD . PRO A 1 120 ? 6.240 50.969 -28.007 1.00 35.41 ? 120 PRO A CD 1 ATOM 953 N N . PHE A 1 121 ? 7.108 52.855 -25.015 1.00 35.88 ? 121 PHE A N 1 ATOM 954 C CA . PHE A 1 121 ? 7.650 53.845 -24.110 1.00 35.30 ? 121 PHE A CA 1 ATOM 955 C C . PHE A 1 121 ? 6.678 54.926 -23.697 1.00 35.06 ? 121 PHE A C 1 ATOM 956 O O . PHE A 1 121 ? 7.081 55.898 -23.074 1.00 37.10 ? 121 PHE A O 1 ATOM 957 C CB . PHE A 1 121 ? 8.903 54.477 -24.719 1.00 35.27 ? 121 PHE A CB 1 ATOM 958 C CG . PHE A 1 121 ? 10.028 53.498 -24.937 1.00 34.56 ? 121 PHE A CG 1 ATOM 959 C CD1 . PHE A 1 121 ? 10.007 52.240 -24.324 1.00 33.07 ? 121 PHE A CD1 1 ATOM 960 C CD2 . PHE A 1 121 ? 11.132 53.846 -25.715 1.00 33.55 ? 121 PHE A CD2 1 ATOM 961 C CE1 . PHE A 1 121 ? 11.068 51.345 -24.479 1.00 32.30 ? 121 PHE A CE1 1 ATOM 962 C CE2 . PHE A 1 121 ? 12.201 52.960 -25.876 1.00 32.56 ? 121 PHE A CE2 1 ATOM 963 C CZ . PHE A 1 121 ? 12.168 51.705 -25.254 1.00 32.44 ? 121 PHE A CZ 1 ATOM 964 N N . LEU A 1 122 ? 5.407 54.771 -24.036 1.00 33.91 ? 122 LEU A N 1 ATOM 965 C CA . LEU A 1 122 ? 4.408 55.761 -23.647 1.00 35.60 ? 122 LEU A CA 1 ATOM 966 C C . LEU A 1 122 ? 4.962 57.184 -23.591 1.00 36.45 ? 122 LEU A C 1 ATOM 967 O O . LEU A 1 122 ? 4.933 57.825 -22.536 1.00 36.02 ? 122 LEU A O 1 ATOM 968 C CB . LEU A 1 122 ? 3.831 55.404 -22.275 1.00 35.30 ? 122 LEU A CB 1 ATOM 969 C CG . LEU A 1 122 ? 3.089 54.075 -22.116 1.00 35.39 ? 122 LEU A CG 1 ATOM 970 C CD1 . LEU A 1 122 ? 2.646 53.922 -20.672 1.00 35.10 ? 122 LEU A CD1 1 ATOM 971 C CD2 . LEU A 1 122 ? 1.888 54.031 -23.054 1.00 34.64 ? 122 LEU A CD2 1 ATOM 972 N N . ARG A 1 123 ? 5.450 57.672 -24.729 1.00 37.58 ? 123 ARG A N 1 ATOM 973 C CA . ARG A 1 123 ? 6.026 59.005 -24.828 1.00 38.83 ? 123 ARG A CA 1 ATOM 974 C C . ARG A 1 123 ? 5.041 60.173 -24.804 1.00 40.13 ? 123 ARG A C 1 ATOM 975 O O . ARG A 1 123 ? 5.154 61.055 -23.956 1.00 41.60 ? 123 ARG A O 1 ATOM 976 C CB . ARG A 1 123 ? 6.901 59.075 -26.074 1.00 38.39 ? 123 ARG A CB 1 ATOM 977 C CG . ARG A 1 123 ? 8.237 58.412 -25.872 1.00 41.11 ? 123 ARG A CG 1 ATOM 978 C CD . ARG A 1 123 ? 9.019 58.318 -27.156 1.00 44.50 ? 123 ARG A CD 1 ATOM 979 N NE . ARG A 1 123 ? 8.659 57.116 -27.895 1.00 47.41 ? 123 ARG A NE 1 ATOM 980 C CZ . ARG A 1 123 ? 9.544 56.227 -28.332 1.00 48.53 ? 123 ARG A CZ 1 ATOM 981 N NH1 . ARG A 1 123 ? 10.839 56.425 -28.096 1.00 48.68 ? 123 ARG A NH1 1 ATOM 982 N NH2 . ARG A 1 123 ? 9.138 55.142 -28.991 1.00 46.20 ? 123 ARG A NH2 1 ATOM 983 N N . GLU A 1 124 ? 4.078 60.191 -25.719 1.00 41.75 ? 124 GLU A N 1 ATOM 984 C CA . GLU A 1 124 ? 3.100 61.280 -25.759 1.00 43.08 ? 124 GLU A CA 1 ATOM 985 C C . GLU A 1 124 ? 1.947 61.067 -24.783 1.00 41.82 ? 124 GLU A C 1 ATOM 986 O O . GLU A 1 124 ? 1.347 59.992 -24.741 1.00 42.35 ? 124 GLU A O 1 ATOM 987 C CB . GLU A 1 124 ? 2.533 61.445 -27.175 1.00 46.57 ? 124 GLU A CB 1 ATOM 988 C CG . GLU A 1 124 ? 3.505 62.018 -28.206 1.00 51.84 ? 124 GLU A CG 1 ATOM 989 C CD . GLU A 1 124 ? 4.596 61.035 -28.629 1.00 56.44 ? 124 GLU A CD 1 ATOM 990 O OE1 . GLU A 1 124 ? 4.264 59.863 -28.929 1.00 59.47 ? 124 GLU A OE1 1 ATOM 991 O OE2 . GLU A 1 124 ? 5.783 61.436 -28.681 1.00 58.44 ? 124 GLU A OE2 1 ATOM 992 N N . TRP A 1 125 ? 1.631 62.099 -24.011 1.00 40.34 ? 125 TRP A N 1 ATOM 993 C CA . TRP A 1 125 ? 0.550 62.012 -23.036 1.00 39.45 ? 125 TRP A CA 1 ATOM 994 C C . TRP A 1 125 ? -0.533 63.047 -23.269 1.00 40.23 ? 125 TRP A C 1 ATOM 995 O O . TRP A 1 125 ? -0.232 64.214 -23.525 1.00 40.94 ? 125 TRP A O 1 ATOM 996 C CB . TRP A 1 125 ? 1.107 62.186 -21.628 1.00 36.95 ? 125 TRP A CB 1 ATOM 997 C CG . TRP A 1 125 ? 1.815 60.990 -21.158 1.00 33.84 ? 125 TRP A CG 1 ATOM 998 C CD1 . TRP A 1 125 ? 2.984 60.490 -21.637 1.00 32.65 ? 125 TRP A CD1 1 ATOM 999 C CD2 . TRP A 1 125 ? 1.361 60.083 -20.162 1.00 32.66 ? 125 TRP A CD2 1 ATOM 1000 N NE1 . TRP A 1 125 ? 3.287 59.314 -21.005 1.00 32.49 ? 125 TRP A NE1 1 ATOM 1001 C CE2 . TRP A 1 125 ? 2.301 59.038 -20.091 1.00 32.84 ? 125 TRP A CE2 1 ATOM 1002 C CE3 . TRP A 1 125 ? 0.241 60.046 -19.320 1.00 32.39 ? 125 TRP A CE3 1 ATOM 1003 C CZ2 . TRP A 1 125 ? 2.161 57.964 -19.208 1.00 32.96 ? 125 TRP A CZ2 1 ATOM 1004 C CZ3 . TRP A 1 125 ? 0.100 58.981 -18.442 1.00 31.50 ? 125 TRP A CZ3 1 ATOM 1005 C CH2 . TRP A 1 125 ? 1.055 57.954 -18.396 1.00 32.80 ? 125 TRP A CH2 1 ATOM 1006 N N . VAL A 1 126 ? -1.788 62.620 -23.159 1.00 39.55 ? 126 VAL A N 1 ATOM 1007 C CA . VAL A 1 126 ? -2.920 63.515 -23.352 1.00 39.73 ? 126 VAL A CA 1 ATOM 1008 C C . VAL A 1 126 ? -3.667 63.802 -22.033 1.00 40.08 ? 126 VAL A C 1 ATOM 1009 O O . VAL A 1 126 ? -3.738 62.948 -21.139 1.00 39.35 ? 126 VAL A O 1 ATOM 1010 C CB . VAL A 1 126 ? -3.900 62.934 -24.385 1.00 38.97 ? 126 VAL A CB 1 ATOM 1011 C CG1 . VAL A 1 126 ? -4.448 61.619 -23.888 1.00 39.98 ? 126 VAL A CG1 1 ATOM 1012 C CG2 . VAL A 1 126 ? -5.028 63.910 -24.637 1.00 40.63 ? 126 VAL A CG2 1 ATOM 1013 N N . LYS A 1 127 ? -4.222 65.009 -21.924 1.00 40.36 ? 127 LYS A N 1 ATOM 1014 C CA . LYS A 1 127 ? -4.929 65.434 -20.721 1.00 40.36 ? 127 LYS A CA 1 ATOM 1015 C C . LYS A 1 127 ? -6.432 65.484 -20.870 1.00 41.48 ? 127 LYS A C 1 ATOM 1016 O O . LYS A 1 127 ? -6.949 65.711 -21.954 1.00 42.36 ? 127 LYS A O 1 ATOM 1017 C CB . LYS A 1 127 ? -4.407 66.797 -20.279 1.00 38.50 ? 127 LYS A CB 1 ATOM 1018 C CG . LYS A 1 127 ? -2.920 66.755 -20.012 1.00 38.31 ? 127 LYS A CG 1 ATOM 1019 C CD . LYS A 1 127 ? -2.333 68.099 -19.704 1.00 38.31 ? 127 LYS A CD 1 ATOM 1020 C CE . LYS A 1 127 ? -0.820 67.982 -19.612 1.00 38.68 ? 127 LYS A CE 1 ATOM 1021 N NZ . LYS A 1 127 ? -0.154 69.311 -19.534 1.00 38.82 ? 127 LYS A NZ 1 ATOM 1022 N N . HIS A 1 128 ? -7.135 65.268 -19.767 1.00 43.79 ? 128 HIS A N 1 ATOM 1023 C CA . HIS A 1 128 ? -8.584 65.282 -19.798 1.00 45.91 ? 128 HIS A CA 1 ATOM 1024 C C . HIS A 1 128 ? -9.082 66.700 -19.974 1.00 48.30 ? 128 HIS A C 1 ATOM 1025 O O . HIS A 1 128 ? -8.484 67.645 -19.461 1.00 49.24 ? 128 HIS A O 1 ATOM 1026 C CB . HIS A 1 128 ? -9.158 64.722 -18.512 1.00 44.83 ? 128 HIS A CB 1 ATOM 1027 C CG . HIS A 1 128 ? -10.578 64.277 -18.642 1.00 45.46 ? 128 HIS A CG 1 ATOM 1028 N ND1 . HIS A 1 128 ? -10.924 62.990 -19.003 1.00 45.92 ? 128 HIS A ND1 1 ATOM 1029 C CD2 . HIS A 1 128 ? -11.743 64.944 -18.472 1.00 43.89 ? 128 HIS A CD2 1 ATOM 1030 C CE1 . HIS A 1 128 ? -12.238 62.883 -19.043 1.00 44.69 ? 128 HIS A CE1 1 ATOM 1031 N NE2 . HIS A 1 128 ? -12.759 64.055 -18.724 1.00 45.70 ? 128 HIS A NE2 1 ATOM 1032 N N . PRO A 1 129 ? -10.187 66.873 -20.711 1.00 49.71 ? 129 PRO A N 1 ATOM 1033 C CA . PRO A 1 129 ? -10.726 68.215 -20.923 1.00 50.20 ? 129 PRO A CA 1 ATOM 1034 C C . PRO A 1 129 ? -11.313 68.813 -19.650 1.00 51.98 ? 129 PRO A C 1 ATOM 1035 O O . PRO A 1 129 ? -11.253 70.024 -19.454 1.00 53.29 ? 129 PRO A O 1 ATOM 1036 C CB . PRO A 1 129 ? -11.781 67.993 -21.997 1.00 49.25 ? 129 PRO A CB 1 ATOM 1037 C CG . PRO A 1 129 ? -11.238 66.824 -22.760 1.00 49.60 ? 129 PRO A CG 1 ATOM 1038 C CD . PRO A 1 129 ? -10.805 65.917 -21.642 1.00 49.54 ? 129 PRO A CD 1 ATOM 1039 N N . LYS A 1 130 ? -11.859 67.966 -18.777 1.00 52.49 ? 130 LYS A N 1 ATOM 1040 C CA . LYS A 1 130 ? -12.465 68.443 -17.532 1.00 52.72 ? 130 LYS A CA 1 ATOM 1041 C C . LYS A 1 130 ? -11.503 68.906 -16.426 1.00 51.93 ? 130 LYS A C 1 ATOM 1042 O O . LYS A 1 130 ? -11.954 69.298 -15.346 1.00 51.63 ? 130 LYS A O 1 ATOM 1043 C CB . LYS A 1 130 ? -13.412 67.379 -16.967 1.00 53.95 ? 130 LYS A CB 1 ATOM 1044 C CG . LYS A 1 130 ? -14.557 67.026 -17.905 1.00 58.08 ? 130 LYS A CG 1 ATOM 1045 C CD . LYS A 1 130 ? -15.662 66.252 -17.194 1.00 61.59 ? 130 LYS A CD 1 ATOM 1046 C CE . LYS A 1 130 ? -16.396 67.140 -16.190 1.00 65.22 ? 130 LYS A CE 1 ATOM 1047 N NZ . LYS A 1 130 ? -17.469 66.422 -15.438 1.00 66.73 ? 130 LYS A NZ 1 ATOM 1048 N N . ASN A 1 131 ? -10.195 68.873 -16.685 1.00 50.17 ? 131 ASN A N 1 ATOM 1049 C CA . ASN A 1 131 ? -9.216 69.305 -15.684 1.00 48.21 ? 131 ASN A CA 1 ATOM 1050 C C . ASN A 1 131 ? -9.437 70.756 -15.298 1.00 46.65 ? 131 ASN A C 1 ATOM 1051 O O . ASN A 1 131 ? -9.745 71.587 -16.147 1.00 47.18 ? 131 ASN A O 1 ATOM 1052 C CB . ASN A 1 131 ? -7.785 69.170 -16.207 1.00 49.20 ? 131 ASN A CB 1 ATOM 1053 C CG . ASN A 1 131 ? -7.296 67.743 -16.212 1.00 50.33 ? 131 ASN A CG 1 ATOM 1054 O OD1 . ASN A 1 131 ? -7.710 66.928 -15.388 1.00 51.06 ? 131 ASN A OD1 1 ATOM 1055 N ND2 . ASN A 1 131 ? -6.386 67.435 -17.133 1.00 50.86 ? 131 ASN A ND2 1 ATOM 1056 N N . PRO A 1 132 ? -9.285 71.082 -14.006 1.00 45.07 ? 132 PRO A N 1 ATOM 1057 C CA . PRO A 1 132 ? -8.921 70.198 -12.892 1.00 44.46 ? 132 PRO A CA 1 ATOM 1058 C C . PRO A 1 132 ? -10.085 69.365 -12.357 1.00 43.22 ? 132 PRO A C 1 ATOM 1059 O O . PRO A 1 132 ? -11.177 69.886 -12.151 1.00 43.16 ? 132 PRO A O 1 ATOM 1060 C CB . PRO A 1 132 ? -8.388 71.173 -11.846 1.00 44.98 ? 132 PRO A CB 1 ATOM 1061 C CG . PRO A 1 132 ? -9.199 72.396 -12.089 1.00 44.50 ? 132 PRO A CG 1 ATOM 1062 C CD . PRO A 1 132 ? -9.186 72.492 -13.596 1.00 45.11 ? 132 PRO A CD 1 ATOM 1063 N N . LEU A 1 133 ? -9.837 68.076 -12.125 1.00 42.30 ? 133 LEU A N 1 ATOM 1064 C CA . LEU A 1 133 ? -10.861 67.167 -11.615 1.00 42.06 ? 133 LEU A CA 1 ATOM 1065 C C . LEU A 1 133 ? -11.159 67.393 -10.146 1.00 43.59 ? 133 LEU A C 1 ATOM 1066 O O . LEU A 1 133 ? -12.194 66.955 -9.649 1.00 45.05 ? 133 LEU A O 1 ATOM 1067 C CB . LEU A 1 133 ? -10.446 65.709 -11.803 1.00 39.21 ? 133 LEU A CB 1 ATOM 1068 C CG . LEU A 1 133 ? -10.829 65.026 -13.112 1.00 37.68 ? 133 LEU A CG 1 ATOM 1069 C CD1 . LEU A 1 133 ? -10.346 65.848 -14.282 1.00 38.01 ? 133 LEU A CD1 1 ATOM 1070 C CD2 . LEU A 1 133 ? -10.217 63.638 -13.146 1.00 38.76 ? 133 LEU A CD2 1 ATOM 1071 N N . ILE A 1 134 ? -10.252 68.064 -9.448 1.00 44.51 ? 134 ILE A N 1 ATOM 1072 C CA . ILE A 1 134 ? -10.447 68.341 -8.031 1.00 44.80 ? 134 ILE A CA 1 ATOM 1073 C C . ILE A 1 134 ? -9.768 69.658 -7.671 1.00 46.67 ? 134 ILE A C 1 ATOM 1074 O O . ILE A 1 134 ? -8.683 69.967 -8.166 1.00 47.02 ? 134 ILE A O 1 ATOM 1075 C CB . ILE A 1 134 ? -9.849 67.217 -7.153 1.00 42.89 ? 134 ILE A CB 1 ATOM 1076 C CG1 . ILE A 1 134 ? -10.369 65.856 -7.606 1.00 40.40 ? 134 ILE A CG1 1 ATOM 1077 C CG2 . ILE A 1 134 ? -10.241 67.425 -5.709 1.00 42.16 ? 134 ILE A CG2 1 ATOM 1078 C CD1 . ILE A 1 134 ? -9.701 64.698 -6.916 1.00 40.14 ? 134 ILE A CD1 1 ATOM 1079 N N . THR A 1 135 ? -10.416 70.440 -6.818 1.00 48.89 ? 135 THR A N 1 ATOM 1080 C CA . THR A 1 135 ? -9.855 71.713 -6.379 1.00 51.80 ? 135 THR A CA 1 ATOM 1081 C C . THR A 1 135 ? -9.926 71.787 -4.863 1.00 53.50 ? 135 THR A C 1 ATOM 1082 O O . THR A 1 135 ? -10.769 71.140 -4.244 1.00 53.99 ? 135 THR A O 1 ATOM 1083 C CB . THR A 1 135 ? -10.621 72.883 -6.961 1.00 52.27 ? 135 THR A CB 1 ATOM 1084 O OG1 . THR A 1 135 ? -12.023 72.674 -6.752 1.00 55.46 ? 135 THR A OG1 1 ATOM 1085 C CG2 . THR A 1 135 ? -10.327 73.024 -8.444 1.00 51.64 ? 135 THR A CG2 1 ATOM 1086 N N . PRO A 1 136 ? -9.051 72.594 -4.246 1.00 55.54 ? 136 PRO A N 1 ATOM 1087 C CA . PRO A 1 136 ? -9.002 72.751 -2.787 1.00 57.21 ? 136 PRO A CA 1 ATOM 1088 C C . PRO A 1 136 ? -10.367 72.791 -2.107 1.00 59.13 ? 136 PRO A C 1 ATOM 1089 O O . PRO A 1 136 ? -11.180 73.671 -2.387 1.00 59.30 ? 136 PRO A O 1 ATOM 1090 C CB . PRO A 1 136 ? -8.229 74.053 -2.613 1.00 57.27 ? 136 PRO A CB 1 ATOM 1091 C CG . PRO A 1 136 ? -7.279 74.027 -3.776 1.00 56.97 ? 136 PRO A CG 1 ATOM 1092 C CD . PRO A 1 136 ? -8.178 73.583 -4.908 1.00 55.96 ? 136 PRO A CD 1 ATOM 1093 N N . PRO A 1 137 ? -10.635 71.832 -1.203 1.00 61.28 ? 137 PRO A N 1 ATOM 1094 C CA . PRO A 1 137 ? -11.921 71.789 -0.498 1.00 63.34 ? 137 PRO A CA 1 ATOM 1095 C C . PRO A 1 137 ? -12.212 73.010 0.379 1.00 65.58 ? 137 PRO A C 1 ATOM 1096 O O . PRO A 1 137 ? -11.387 73.923 0.486 1.00 65.64 ? 137 PRO A O 1 ATOM 1097 C CB . PRO A 1 137 ? -11.846 70.479 0.297 1.00 62.58 ? 137 PRO A CB 1 ATOM 1098 C CG . PRO A 1 137 ? -10.385 70.261 0.481 1.00 62.01 ? 137 PRO A CG 1 ATOM 1099 C CD . PRO A 1 137 ? -9.806 70.667 -0.851 1.00 61.70 ? 137 PRO A CD 1 ATOM 1100 N N . GLU A 1 138 ? -13.395 73.013 0.991 1.00 67.75 ? 138 GLU A N 1 ATOM 1101 C CA . GLU A 1 138 ? -13.858 74.111 1.840 1.00 69.34 ? 138 GLU A CA 1 ATOM 1102 C C . GLU A 1 138 ? -12.825 74.941 2.586 1.00 68.50 ? 138 GLU A C 1 ATOM 1103 O O . GLU A 1 138 ? -12.563 76.084 2.211 1.00 69.38 ? 138 GLU A O 1 ATOM 1104 C CB . GLU A 1 138 ? -14.892 73.596 2.839 1.00 72.98 ? 138 GLU A CB 1 ATOM 1105 C CG . GLU A 1 138 ? -16.326 73.658 2.326 1.00 78.49 ? 138 GLU A CG 1 ATOM 1106 C CD . GLU A 1 138 ? -16.850 75.088 2.213 1.00 81.20 ? 138 GLU A CD 1 ATOM 1107 O OE1 . GLU A 1 138 ? -18.022 75.264 1.802 1.00 82.70 ? 138 GLU A OE1 1 ATOM 1108 O OE2 . GLU A 1 138 ? -16.091 76.032 2.536 1.00 81.38 ? 138 GLU A OE2 1 ATOM 1109 N N . GLY A 1 139 ? -12.244 74.378 3.640 1.00 66.61 ? 139 GLY A N 1 ATOM 1110 C CA . GLY A 1 139 ? -11.282 75.137 4.418 1.00 65.43 ? 139 GLY A CA 1 ATOM 1111 C C . GLY A 1 139 ? -9.810 74.917 4.131 1.00 65.11 ? 139 GLY A C 1 ATOM 1112 O O . GLY A 1 139 ? -8.994 74.914 5.060 1.00 65.78 ? 139 GLY A O 1 ATOM 1113 N N . VAL A 1 140 ? -9.453 74.755 2.860 1.00 63.17 ? 140 VAL A N 1 ATOM 1114 C CA . VAL A 1 140 ? -8.061 74.526 2.501 1.00 60.68 ? 140 VAL A CA 1 ATOM 1115 C C . VAL A 1 140 ? -7.489 75.631 1.627 1.00 60.67 ? 140 VAL A C 1 ATOM 1116 O O . VAL A 1 140 ? -8.129 76.073 0.677 1.00 61.12 ? 140 VAL A O 1 ATOM 1117 C CB . VAL A 1 140 ? -7.906 73.196 1.768 1.00 59.02 ? 140 VAL A CB 1 ATOM 1118 C CG1 . VAL A 1 140 ? -6.450 72.937 1.488 1.00 58.61 ? 140 VAL A CG1 1 ATOM 1119 C CG2 . VAL A 1 140 ? -8.496 72.076 2.603 1.00 58.62 ? 140 VAL A CG2 1 ATOM 1120 N N . LYS A 1 141 ? -6.278 76.072 1.948 1.00 60.76 ? 141 LYS A N 1 ATOM 1121 C CA . LYS A 1 141 ? -5.625 77.130 1.187 1.00 61.09 ? 141 LYS A CA 1 ATOM 1122 C C . LYS A 1 141 ? -5.292 76.606 -0.205 1.00 60.74 ? 141 LYS A C 1 ATOM 1123 O O . LYS A 1 141 ? -5.194 75.404 -0.401 1.00 60.88 ? 141 LYS A O 1 ATOM 1124 C CB . LYS A 1 141 ? -4.330 77.563 1.878 1.00 63.24 ? 141 LYS A CB 1 ATOM 1125 C CG . LYS A 1 141 ? -4.315 77.419 3.398 1.00 66.12 ? 141 LYS A CG 1 ATOM 1126 C CD . LYS A 1 141 ? -5.338 78.305 4.099 1.00 68.03 ? 141 LYS A CD 1 ATOM 1127 C CE . LYS A 1 141 ? -5.114 79.786 3.817 1.00 68.59 ? 141 LYS A CE 1 ATOM 1128 N NZ . LYS A 1 141 ? -5.575 80.178 2.453 1.00 70.19 ? 141 LYS A NZ 1 ATOM 1129 N N . ASP A 1 142 ? -5.104 77.504 -1.166 1.00 61.21 ? 142 ASP A N 1 ATOM 1130 C CA . ASP A 1 142 ? -4.775 77.099 -2.530 1.00 61.61 ? 142 ASP A CA 1 ATOM 1131 C C . ASP A 1 142 ? -3.334 76.653 -2.688 1.00 60.23 ? 142 ASP A C 1 ATOM 1132 O O . ASP A 1 142 ? -2.927 76.238 -3.767 1.00 59.78 ? 142 ASP A O 1 ATOM 1133 C CB . ASP A 1 142 ? -5.055 78.237 -3.510 1.00 65.00 ? 142 ASP A CB 1 ATOM 1134 C CG . ASP A 1 142 ? -6.538 78.423 -3.778 1.00 68.40 ? 142 ASP A CG 1 ATOM 1135 O OD1 . ASP A 1 142 ? -6.891 79.342 -4.553 1.00 70.00 ? 142 ASP A OD1 1 ATOM 1136 O OD2 . ASP A 1 142 ? -7.350 77.648 -3.215 1.00 69.19 ? 142 ASP A OD2 1 ATOM 1137 N N . ASP A 1 143 ? -2.563 76.748 -1.614 1.00 59.55 ? 143 ASP A N 1 ATOM 1138 C CA . ASP A 1 143 ? -1.169 76.336 -1.646 1.00 59.58 ? 143 ASP A CA 1 ATOM 1139 C C . ASP A 1 143 ? -0.935 75.280 -0.590 1.00 57.90 ? 143 ASP A C 1 ATOM 1140 O O . ASP A 1 143 ? 0.154 75.181 -0.022 1.00 59.32 ? 143 ASP A O 1 ATOM 1141 C CB . ASP A 1 143 ? -0.254 77.531 -1.396 1.00 63.55 ? 143 ASP A CB 1 ATOM 1142 C CG . ASP A 1 143 ? -0.079 78.390 -2.630 1.00 68.56 ? 143 ASP A CG 1 ATOM 1143 O OD1 . ASP A 1 143 ? 0.416 77.861 -3.654 1.00 71.38 ? 143 ASP A OD1 1 ATOM 1144 O OD2 . ASP A 1 143 ? -0.433 79.590 -2.583 1.00 71.31 ? 143 ASP A OD2 1 ATOM 1145 N N . CYS A 1 144 ? -1.967 74.485 -0.335 1.00 54.90 ? 144 CYS A N 1 ATOM 1146 C CA . CYS A 1 144 ? -1.898 73.434 0.667 1.00 52.28 ? 144 CYS A CA 1 ATOM 1147 C C . CYS A 1 144 ? -2.772 72.252 0.258 1.00 49.52 ? 144 CYS A C 1 ATOM 1148 O O . CYS A 1 144 ? -3.484 71.691 1.086 1.00 49.97 ? 144 CYS A O 1 ATOM 1149 C CB . CYS A 1 144 ? -2.382 73.981 2.020 1.00 53.62 ? 144 CYS A CB 1 ATOM 1150 S SG . CYS A 1 144 ? -1.453 75.401 2.709 1.00 56.19 ? 144 CYS A SG 1 ATOM 1151 N N . PHE A 1 145 ? -2.706 71.861 -1.010 1.00 46.13 ? 145 PHE A N 1 ATOM 1152 C CA . PHE A 1 145 ? -3.535 70.768 -1.511 1.00 44.04 ? 145 PHE A CA 1 ATOM 1153 C C . PHE A 1 145 ? -2.837 70.134 -2.709 1.00 43.71 ? 145 PHE A C 1 ATOM 1154 O O . PHE A 1 145 ? -3.005 70.596 -3.832 1.00 44.97 ? 145 PHE A O 1 ATOM 1155 C CB . PHE A 1 145 ? -4.883 71.356 -1.929 1.00 42.66 ? 145 PHE A CB 1 ATOM 1156 C CG . PHE A 1 145 ? -5.881 70.348 -2.394 1.00 41.85 ? 145 PHE A CG 1 ATOM 1157 C CD1 . PHE A 1 145 ? -6.272 69.295 -1.570 1.00 42.66 ? 145 PHE A CD1 1 ATOM 1158 C CD2 . PHE A 1 145 ? -6.471 70.475 -3.645 1.00 40.50 ? 145 PHE A CD2 1 ATOM 1159 C CE1 . PHE A 1 145 ? -7.253 68.384 -1.984 1.00 41.61 ? 145 PHE A CE1 1 ATOM 1160 C CE2 . PHE A 1 145 ? -7.447 69.577 -4.069 1.00 41.04 ? 145 PHE A CE2 1 ATOM 1161 C CZ . PHE A 1 145 ? -7.839 68.525 -3.237 1.00 41.29 ? 145 PHE A CZ 1 ATOM 1162 N N . ARG A 1 146 ? -2.070 69.072 -2.492 1.00 42.26 ? 146 ARG A N 1 ATOM 1163 C CA . ARG A 1 146 ? -1.349 68.482 -3.612 1.00 41.22 ? 146 ARG A CA 1 ATOM 1164 C C . ARG A 1 146 ? -0.875 67.032 -3.481 1.00 41.13 ? 146 ARG A C 1 ATOM 1165 O O . ARG A 1 146 ? -1.093 66.370 -2.464 1.00 41.36 ? 146 ARG A O 1 ATOM 1166 C CB . ARG A 1 146 ? -0.141 69.360 -3.922 1.00 40.68 ? 146 ARG A CB 1 ATOM 1167 C CG . ARG A 1 146 ? 0.754 69.563 -2.720 1.00 40.93 ? 146 ARG A CG 1 ATOM 1168 C CD . ARG A 1 146 ? 1.936 70.460 -3.031 1.00 43.95 ? 146 ARG A CD 1 ATOM 1169 N NE . ARG A 1 146 ? 2.798 70.656 -1.863 1.00 47.09 ? 146 ARG A NE 1 ATOM 1170 C CZ . ARG A 1 146 ? 2.504 71.428 -0.818 1.00 47.38 ? 146 ARG A CZ 1 ATOM 1171 N NH1 . ARG A 1 146 ? 1.358 72.096 -0.784 1.00 48.93 ? 146 ARG A NH1 1 ATOM 1172 N NH2 . ARG A 1 146 ? 3.357 71.532 0.194 1.00 46.13 ? 146 ARG A NH2 1 ATOM 1173 N N . ASP A 1 147 ? -0.230 66.560 -4.549 1.00 40.13 ? 147 ASP A N 1 ATOM 1174 C CA . ASP A 1 147 ? 0.336 65.219 -4.641 1.00 39.16 ? 147 ASP A CA 1 ATOM 1175 C C . ASP A 1 147 ? -0.644 64.052 -4.551 1.00 39.19 ? 147 ASP A C 1 ATOM 1176 O O . ASP A 1 147 ? -0.569 63.236 -3.626 1.00 41.17 ? 147 ASP A O 1 ATOM 1177 C CB . ASP A 1 147 ? 1.420 65.051 -3.579 1.00 38.25 ? 147 ASP A CB 1 ATOM 1178 C CG . ASP A 1 147 ? 2.336 66.242 -3.505 1.00 38.95 ? 147 ASP A CG 1 ATOM 1179 O OD1 . ASP A 1 147 ? 2.300 67.074 -4.432 1.00 40.89 ? 147 ASP A OD1 1 ATOM 1180 O OD2 . ASP A 1 147 ? 3.098 66.354 -2.526 1.00 40.50 ? 147 ASP A OD2 1 ATOM 1181 N N . PRO A 1 148 ? -1.560 63.935 -5.522 1.00 37.76 ? 148 PRO A N 1 ATOM 1182 C CA . PRO A 1 148 ? -2.525 62.829 -5.488 1.00 36.09 ? 148 PRO A CA 1 ATOM 1183 C C . PRO A 1 148 ? -1.813 61.470 -5.545 1.00 34.59 ? 148 PRO A C 1 ATOM 1184 O O . PRO A 1 148 ? -0.882 61.278 -6.328 1.00 32.97 ? 148 PRO A O 1 ATOM 1185 C CB . PRO A 1 148 ? -3.392 63.099 -6.714 1.00 36.01 ? 148 PRO A CB 1 ATOM 1186 C CG . PRO A 1 148 ? -2.422 63.746 -7.668 1.00 37.09 ? 148 PRO A CG 1 ATOM 1187 C CD . PRO A 1 148 ? -1.680 64.708 -6.771 1.00 37.40 ? 148 PRO A CD 1 ATOM 1188 N N . SER A 1 149 ? -2.256 60.532 -4.714 1.00 33.82 ? 149 SER A N 1 ATOM 1189 C CA . SER A 1 149 ? -1.642 59.208 -4.654 1.00 33.99 ? 149 SER A CA 1 ATOM 1190 C C . SER A 1 149 ? -2.130 58.271 -5.733 1.00 33.99 ? 149 SER A C 1 ATOM 1191 O O . SER A 1 149 ? -2.946 58.632 -6.568 1.00 35.53 ? 149 SER A O 1 ATOM 1192 C CB . SER A 1 149 ? -1.941 58.543 -3.313 1.00 34.18 ? 149 SER A CB 1 ATOM 1193 O OG . SER A 1 149 ? -3.215 57.919 -3.348 1.00 33.50 ? 149 SER A OG 1 ATOM 1194 N N . THR A 1 150 ? -1.612 57.052 -5.709 1.00 33.96 ? 150 THR A N 1 ATOM 1195 C CA . THR A 1 150 ? -2.042 56.033 -6.650 1.00 33.90 ? 150 THR A CA 1 ATOM 1196 C C . THR A 1 150 ? -3.394 55.611 -6.101 1.00 34.72 ? 150 THR A C 1 ATOM 1197 O O . THR A 1 150 ? -3.583 55.581 -4.882 1.00 35.20 ? 150 THR A O 1 ATOM 1198 C CB . THR A 1 150 ? -1.100 54.832 -6.623 1.00 33.10 ? 150 THR A CB 1 ATOM 1199 O OG1 . THR A 1 150 ? 0.149 55.200 -7.217 1.00 33.16 ? 150 THR A OG1 1 ATOM 1200 C CG2 . THR A 1 150 ? -1.705 53.661 -7.361 1.00 31.56 ? 150 THR A CG2 1 ATOM 1201 N N . ALA A 1 151 ? -4.334 55.289 -6.978 1.00 34.91 ? 151 ALA A N 1 ATOM 1202 C CA . ALA A 1 151 ? -5.657 54.892 -6.520 1.00 35.66 ? 151 ALA A CA 1 ATOM 1203 C C . ALA A 1 151 ? -5.790 53.401 -6.245 1.00 36.72 ? 151 ALA A C 1 ATOM 1204 O O . ALA A 1 151 ? -5.021 52.574 -6.768 1.00 36.72 ? 151 ALA A O 1 ATOM 1205 C CB . ALA A 1 151 ? -6.701 55.313 -7.531 1.00 35.08 ? 151 ALA A CB 1 ATOM 1206 N N . TRP A 1 152 ? -6.764 53.072 -5.400 1.00 37.19 ? 152 TRP A N 1 ATOM 1207 C CA . TRP A 1 152 ? -7.060 51.689 -5.059 1.00 39.02 ? 152 TRP A CA 1 ATOM 1208 C C . TRP A 1 152 ? -8.559 51.481 -5.212 1.00 40.72 ? 152 TRP A C 1 ATOM 1209 O O . TRP A 1 152 ? -9.367 52.332 -4.833 1.00 41.27 ? 152 TRP A O 1 ATOM 1210 C CB . TRP A 1 152 ? -6.576 51.342 -3.642 1.00 39.31 ? 152 TRP A CB 1 ATOM 1211 C CG . TRP A 1 152 ? -7.129 52.165 -2.508 1.00 39.98 ? 152 TRP A CG 1 ATOM 1212 C CD1 . TRP A 1 152 ? -8.175 51.845 -1.698 1.00 39.72 ? 152 TRP A CD1 1 ATOM 1213 C CD2 . TRP A 1 152 ? -6.619 53.414 -2.030 1.00 40.18 ? 152 TRP A CD2 1 ATOM 1214 N NE1 . TRP A 1 152 ? -8.347 52.812 -0.738 1.00 39.50 ? 152 TRP A NE1 1 ATOM 1215 C CE2 . TRP A 1 152 ? -7.403 53.791 -0.921 1.00 40.30 ? 152 TRP A CE2 1 ATOM 1216 C CE3 . TRP A 1 152 ? -5.568 54.256 -2.432 1.00 41.05 ? 152 TRP A CE3 1 ATOM 1217 C CZ2 . TRP A 1 152 ? -7.176 54.974 -0.207 1.00 41.20 ? 152 TRP A CZ2 1 ATOM 1218 C CZ3 . TRP A 1 152 ? -5.340 55.437 -1.721 1.00 40.84 ? 152 TRP A CZ3 1 ATOM 1219 C CH2 . TRP A 1 152 ? -6.142 55.781 -0.623 1.00 41.63 ? 152 TRP A CH2 1 ATOM 1220 N N . LEU A 1 153 ? -8.921 50.347 -5.795 1.00 41.79 ? 153 LEU A N 1 ATOM 1221 C CA . LEU A 1 153 ? -10.315 50.032 -6.058 1.00 43.22 ? 153 LEU A CA 1 ATOM 1222 C C . LEU A 1 153 ? -10.949 49.245 -4.915 1.00 45.32 ? 153 LEU A C 1 ATOM 1223 O O . LEU A 1 153 ? -10.580 48.092 -4.667 1.00 46.73 ? 153 LEU A O 1 ATOM 1224 C CB . LEU A 1 153 ? -10.392 49.256 -7.374 1.00 41.74 ? 153 LEU A CB 1 ATOM 1225 C CG . LEU A 1 153 ? -11.720 49.097 -8.100 1.00 40.54 ? 153 LEU A CG 1 ATOM 1226 C CD1 . LEU A 1 153 ? -12.397 50.434 -8.255 1.00 40.77 ? 153 LEU A CD1 1 ATOM 1227 C CD2 . LEU A 1 153 ? -11.455 48.488 -9.457 1.00 39.07 ? 153 LEU A CD2 1 ATOM 1228 N N . GLY A 1 154 ? -11.895 49.879 -4.219 1.00 46.06 ? 154 GLY A N 1 ATOM 1229 C CA . GLY A 1 154 ? -12.567 49.237 -3.098 1.00 46.12 ? 154 GLY A CA 1 ATOM 1230 C C . GLY A 1 154 ? -13.309 47.987 -3.517 1.00 46.80 ? 154 GLY A C 1 ATOM 1231 O O . GLY A 1 154 ? -13.656 47.853 -4.684 1.00 46.82 ? 154 GLY A O 1 ATOM 1232 N N . PRO A 1 155 ? -13.574 47.050 -2.595 1.00 47.84 ? 155 PRO A N 1 ATOM 1233 C CA . PRO A 1 155 ? -14.291 45.833 -2.986 1.00 47.74 ? 155 PRO A CA 1 ATOM 1234 C C . PRO A 1 155 ? -15.659 46.185 -3.534 1.00 46.80 ? 155 PRO A C 1 ATOM 1235 O O . PRO A 1 155 ? -16.317 45.372 -4.165 1.00 47.62 ? 155 PRO A O 1 ATOM 1236 C CB . PRO A 1 155 ? -14.365 45.040 -1.684 1.00 47.42 ? 155 PRO A CB 1 ATOM 1237 C CG . PRO A 1 155 ? -14.477 46.115 -0.665 1.00 49.15 ? 155 PRO A CG 1 ATOM 1238 C CD . PRO A 1 155 ? -13.442 47.127 -1.131 1.00 49.02 ? 155 PRO A CD 1 ATOM 1239 N N . ASP A 1 156 ? -16.083 47.412 -3.291 1.00 46.66 ? 156 ASP A N 1 ATOM 1240 C CA . ASP A 1 156 ? -17.368 47.856 -3.787 1.00 47.46 ? 156 ASP A CA 1 ATOM 1241 C C . ASP A 1 156 ? -17.156 48.450 -5.166 1.00 47.13 ? 156 ASP A C 1 ATOM 1242 O O . ASP A 1 156 ? -17.999 49.173 -5.679 1.00 48.02 ? 156 ASP A O 1 ATOM 1243 C CB . ASP A 1 156 ? -17.964 48.897 -2.841 1.00 50.04 ? 156 ASP A CB 1 ATOM 1244 C CG . ASP A 1 156 ? -17.055 50.088 -2.636 1.00 52.62 ? 156 ASP A CG 1 ATOM 1245 O OD1 . ASP A 1 156 ? -15.824 49.889 -2.529 1.00 55.38 ? 156 ASP A OD1 1 ATOM 1246 O OD2 . ASP A 1 156 ? -17.575 51.223 -2.566 1.00 53.65 ? 156 ASP A OD2 1 ATOM 1247 N N . GLY A 1 157 ? -16.013 48.143 -5.762 1.00 46.69 ? 157 GLY A N 1 ATOM 1248 C CA . GLY A 1 157 ? -15.717 48.655 -7.084 1.00 45.49 ? 157 GLY A CA 1 ATOM 1249 C C . GLY A 1 157 ? -15.677 50.166 -7.189 1.00 44.81 ? 157 GLY A C 1 ATOM 1250 O O . GLY A 1 157 ? -16.070 50.728 -8.203 1.00 45.52 ? 157 GLY A O 1 ATOM 1251 N N . VAL A 1 158 ? -15.211 50.840 -6.149 1.00 45.09 ? 158 VAL A N 1 ATOM 1252 C CA . VAL A 1 158 ? -15.123 52.289 -6.205 1.00 45.52 ? 158 VAL A CA 1 ATOM 1253 C C . VAL A 1 158 ? -13.683 52.728 -5.948 1.00 47.89 ? 158 VAL A C 1 ATOM 1254 O O . VAL A 1 158 ? -13.052 52.290 -4.979 1.00 48.23 ? 158 VAL A O 1 ATOM 1255 C CB . VAL A 1 158 ? -16.045 52.933 -5.176 1.00 43.58 ? 158 VAL A CB 1 ATOM 1256 C CG1 . VAL A 1 158 ? -16.068 54.432 -5.362 1.00 42.10 ? 158 VAL A CG1 1 ATOM 1257 C CG2 . VAL A 1 158 ? -17.419 52.375 -5.330 1.00 42.92 ? 158 VAL A CG2 1 ATOM 1258 N N . TRP A 1 159 ? -13.161 53.578 -6.831 1.00 48.77 ? 159 TRP A N 1 ATOM 1259 C CA . TRP A 1 159 ? -11.795 54.077 -6.708 1.00 49.73 ? 159 TRP A CA 1 ATOM 1260 C C . TRP A 1 159 ? -11.648 54.996 -5.508 1.00 50.50 ? 159 TRP A C 1 ATOM 1261 O O . TRP A 1 159 ? -12.618 55.615 -5.060 1.00 50.94 ? 159 TRP A O 1 ATOM 1262 C CB . TRP A 1 159 ? -11.385 54.842 -7.968 1.00 50.67 ? 159 TRP A CB 1 ATOM 1263 C CG . TRP A 1 159 ? -11.184 53.976 -9.163 1.00 52.72 ? 159 TRP A CG 1 ATOM 1264 C CD1 . TRP A 1 159 ? -11.993 53.882 -10.259 1.00 52.75 ? 159 TRP A CD1 1 ATOM 1265 C CD2 . TRP A 1 159 ? -10.112 53.054 -9.375 1.00 53.43 ? 159 TRP A CD2 1 ATOM 1266 N NE1 . TRP A 1 159 ? -11.488 52.955 -11.140 1.00 53.69 ? 159 TRP A NE1 1 ATOM 1267 C CE2 . TRP A 1 159 ? -10.331 52.430 -10.617 1.00 53.50 ? 159 TRP A CE2 1 ATOM 1268 C CE3 . TRP A 1 159 ? -8.982 52.691 -8.631 1.00 53.83 ? 159 TRP A CE3 1 ATOM 1269 C CZ2 . TRP A 1 159 ? -9.464 51.464 -11.135 1.00 53.71 ? 159 TRP A CZ2 1 ATOM 1270 C CZ3 . TRP A 1 159 ? -8.118 51.729 -9.147 1.00 53.40 ? 159 TRP A CZ3 1 ATOM 1271 C CH2 . TRP A 1 159 ? -8.365 51.129 -10.383 1.00 53.30 ? 159 TRP A CH2 1 ATOM 1272 N N . ARG A 1 160 ? -10.422 55.092 -5.001 1.00 50.72 ? 160 ARG A N 1 ATOM 1273 C CA . ARG A 1 160 ? -10.120 55.943 -3.854 1.00 48.80 ? 160 ARG A CA 1 ATOM 1274 C C . ARG A 1 160 ? -8.699 56.483 -3.966 1.00 47.46 ? 160 ARG A C 1 ATOM 1275 O O . ARG A 1 160 ? -7.794 55.774 -4.415 1.00 47.43 ? 160 ARG A O 1 ATOM 1276 C CB . ARG A 1 160 ? -10.269 55.139 -2.563 1.00 47.97 ? 160 ARG A CB 1 ATOM 1277 C CG . ARG A 1 160 ? -11.677 54.621 -2.323 1.00 48.67 ? 160 ARG A CG 1 ATOM 1278 C CD . ARG A 1 160 ? -11.706 53.745 -1.101 1.00 50.69 ? 160 ARG A CD 1 ATOM 1279 N NE . ARG A 1 160 ? -13.055 53.437 -0.626 1.00 51.46 ? 160 ARG A NE 1 ATOM 1280 C CZ . ARG A 1 160 ? -13.907 52.624 -1.238 1.00 51.99 ? 160 ARG A CZ 1 ATOM 1281 N NH1 . ARG A 1 160 ? -13.568 52.024 -2.372 1.00 52.05 ? 160 ARG A NH1 1 ATOM 1282 N NH2 . ARG A 1 160 ? -15.091 52.386 -0.693 1.00 52.37 ? 160 ARG A NH2 1 ATOM 1283 N N . ILE A 1 161 ? -8.508 57.744 -3.592 1.00 45.79 ? 161 ILE A N 1 ATOM 1284 C CA . ILE A 1 161 ? -7.173 58.342 -3.619 1.00 45.78 ? 161 ILE A CA 1 ATOM 1285 C C . ILE A 1 161 ? -7.017 59.320 -2.463 1.00 46.58 ? 161 ILE A C 1 ATOM 1286 O O . ILE A 1 161 ? -8.004 59.849 -1.956 1.00 48.70 ? 161 ILE A O 1 ATOM 1287 C CB . ILE A 1 161 ? -6.886 59.131 -4.925 1.00 43.09 ? 161 ILE A CB 1 ATOM 1288 C CG1 . ILE A 1 161 ? -7.859 60.297 -5.059 1.00 41.53 ? 161 ILE A CG1 1 ATOM 1289 C CG2 . ILE A 1 161 ? -6.964 58.221 -6.118 1.00 41.42 ? 161 ILE A CG2 1 ATOM 1290 C CD1 . ILE A 1 161 ? -7.501 61.250 -6.170 1.00 41.84 ? 161 ILE A CD1 1 ATOM 1291 N N . VAL A 1 162 ? -5.783 59.543 -2.029 1.00 45.42 ? 162 VAL A N 1 ATOM 1292 C CA . VAL A 1 162 ? -5.540 60.511 -0.971 1.00 44.64 ? 162 VAL A CA 1 ATOM 1293 C C . VAL A 1 162 ? -4.718 61.645 -1.580 1.00 44.72 ? 162 VAL A C 1 ATOM 1294 O O . VAL A 1 162 ? -3.887 61.424 -2.464 1.00 44.61 ? 162 VAL A O 1 ATOM 1295 C CB . VAL A 1 162 ? -4.776 59.905 0.230 1.00 43.60 ? 162 VAL A CB 1 ATOM 1296 C CG1 . VAL A 1 162 ? -5.699 59.039 1.054 1.00 42.65 ? 162 VAL A CG1 1 ATOM 1297 C CG2 . VAL A 1 162 ? -3.597 59.097 -0.260 1.00 44.70 ? 162 VAL A CG2 1 ATOM 1298 N N . VAL A 1 163 ? -4.974 62.864 -1.123 1.00 44.58 ? 163 VAL A N 1 ATOM 1299 C CA . VAL A 1 163 ? -4.262 64.034 -1.614 1.00 43.75 ? 163 VAL A CA 1 ATOM 1300 C C . VAL A 1 163 ? -3.691 64.761 -0.403 1.00 43.94 ? 163 VAL A C 1 ATOM 1301 O O . VAL A 1 163 ? -4.393 64.978 0.589 1.00 42.92 ? 163 VAL A O 1 ATOM 1302 C CB . VAL A 1 163 ? -5.218 64.984 -2.392 1.00 42.82 ? 163 VAL A CB 1 ATOM 1303 C CG1 . VAL A 1 163 ? -4.455 66.164 -2.958 1.00 41.72 ? 163 VAL A CG1 1 ATOM 1304 C CG2 . VAL A 1 163 ? -5.901 64.227 -3.509 1.00 41.89 ? 163 VAL A CG2 1 ATOM 1305 N N . GLY A 1 164 ? -2.413 65.115 -0.472 1.00 44.26 ? 164 GLY A N 1 ATOM 1306 C CA . GLY A 1 164 ? -1.800 65.819 0.637 1.00 46.41 ? 164 GLY A CA 1 ATOM 1307 C C . GLY A 1 164 ? -2.469 67.160 0.881 1.00 48.19 ? 164 GLY A C 1 ATOM 1308 O O . GLY A 1 164 ? -3.205 67.667 0.037 1.00 48.26 ? 164 GLY A O 1 ATOM 1309 N N . GLY A 1 165 ? -2.213 67.743 2.043 1.00 50.67 ? 165 GLY A N 1 ATOM 1310 C CA . GLY A 1 165 ? -2.799 69.030 2.359 1.00 53.57 ? 165 GLY A CA 1 ATOM 1311 C C . GLY A 1 165 ? -2.759 69.299 3.844 1.00 56.10 ? 165 GLY A C 1 ATOM 1312 O O . GLY A 1 165 ? -1.891 68.792 4.549 1.00 56.07 ? 165 GLY A O 1 ATOM 1313 N N . ASP A 1 166 ? -3.704 70.107 4.313 1.00 58.98 ? 166 ASP A N 1 ATOM 1314 C CA . ASP A 1 166 ? -3.810 70.451 5.723 1.00 61.36 ? 166 ASP A CA 1 ATOM 1315 C C . ASP A 1 166 ? -4.947 71.433 5.935 1.00 62.47 ? 166 ASP A C 1 ATOM 1316 O O . ASP A 1 166 ? -5.395 72.104 5.006 1.00 62.29 ? 166 ASP A O 1 ATOM 1317 C CB . ASP A 1 166 ? -2.526 71.104 6.236 1.00 62.65 ? 166 ASP A CB 1 ATOM 1318 C CG . ASP A 1 166 ? -2.397 72.548 5.795 1.00 63.76 ? 166 ASP A CG 1 ATOM 1319 O OD1 . ASP A 1 166 ? -1.851 73.362 6.568 1.00 64.16 ? 166 ASP A OD1 1 ATOM 1320 O OD2 . ASP A 1 166 ? -2.843 72.866 4.673 1.00 65.81 ? 166 ASP A OD2 1 ATOM 1321 N N . ARG A 1 167 ? -5.395 71.521 7.176 1.00 64.33 ? 167 ARG A N 1 ATOM 1322 C CA . ARG A 1 167 ? -6.458 72.432 7.541 1.00 66.20 ? 167 ARG A CA 1 ATOM 1323 C C . ARG A 1 167 ? -5.974 73.044 8.849 1.00 67.11 ? 167 ARG A C 1 ATOM 1324 O O . ARG A 1 167 ? -5.795 72.334 9.837 1.00 67.69 ? 167 ARG A O 1 ATOM 1325 C CB . ARG A 1 167 ? -7.764 71.659 7.748 1.00 66.64 ? 167 ARG A CB 1 ATOM 1326 C CG . ARG A 1 167 ? -9.004 72.450 7.371 1.00 68.62 ? 167 ARG A CG 1 ATOM 1327 C CD . ARG A 1 167 ? -10.262 71.793 7.896 1.00 69.87 ? 167 ARG A CD 1 ATOM 1328 N NE . ARG A 1 167 ? -10.507 70.493 7.285 1.00 70.67 ? 167 ARG A NE 1 ATOM 1329 C CZ . ARG A 1 167 ? -10.952 70.317 6.046 1.00 71.62 ? 167 ARG A CZ 1 ATOM 1330 N NH1 . ARG A 1 167 ? -11.208 71.364 5.266 1.00 70.82 ? 167 ARG A NH1 1 ATOM 1331 N NH2 . ARG A 1 167 ? -11.146 69.085 5.588 1.00 72.73 ? 167 ARG A NH2 1 ATOM 1332 N N . ASP A 1 168 ? -5.737 74.352 8.853 1.00 68.46 ? 168 ASP A N 1 ATOM 1333 C CA . ASP A 1 168 ? -5.249 75.026 10.053 1.00 70.56 ? 168 ASP A CA 1 ATOM 1334 C C . ASP A 1 168 ? -3.894 74.460 10.445 1.00 70.52 ? 168 ASP A C 1 ATOM 1335 O O . ASP A 1 168 ? -3.631 74.176 11.619 1.00 69.93 ? 168 ASP A O 1 ATOM 1336 C CB . ASP A 1 168 ? -6.226 74.848 11.212 1.00 73.37 ? 168 ASP A CB 1 ATOM 1337 C CG . ASP A 1 168 ? -7.506 75.609 11.002 1.00 75.68 ? 168 ASP A CG 1 ATOM 1338 O OD1 . ASP A 1 168 ? -7.421 76.846 10.818 1.00 76.95 ? 168 ASP A OD1 1 ATOM 1339 O OD2 . ASP A 1 168 ? -8.586 74.975 11.022 1.00 76.40 ? 168 ASP A OD2 1 ATOM 1340 N N . ASN A 1 169 ? -3.045 74.293 9.439 1.00 70.13 ? 169 ASN A N 1 ATOM 1341 C CA . ASN A 1 169 ? -1.704 73.768 9.629 1.00 69.45 ? 169 ASN A CA 1 ATOM 1342 C C . ASN A 1 169 ? -1.688 72.329 10.136 1.00 69.23 ? 169 ASN A C 1 ATOM 1343 O O . ASN A 1 169 ? -0.622 71.765 10.383 1.00 70.01 ? 169 ASN A O 1 ATOM 1344 C CB . ASN A 1 169 ? -0.921 74.650 10.589 1.00 68.97 ? 169 ASN A CB 1 ATOM 1345 C CG . ASN A 1 169 ? 0.547 74.328 10.583 1.00 69.38 ? 169 ASN A CG 1 ATOM 1346 O OD1 . ASN A 1 169 ? 1.207 74.448 9.551 1.00 67.37 ? 169 ASN A OD1 1 ATOM 1347 N ND2 . ASN A 1 169 ? 1.072 73.904 11.733 1.00 70.81 ? 169 ASN A ND2 1 ATOM 1348 N N . ASN A 1 170 ? -2.863 71.737 10.307 1.00 68.12 ? 170 ASN A N 1 ATOM 1349 C CA . ASN A 1 170 ? -2.941 70.354 10.750 1.00 66.90 ? 170 ASN A CA 1 ATOM 1350 C C . ASN A 1 170 ? -2.928 69.504 9.491 1.00 65.28 ? 170 ASN A C 1 ATOM 1351 O O . ASN A 1 170 ? -3.935 69.387 8.801 1.00 65.68 ? 170 ASN A O 1 ATOM 1352 C CB . ASN A 1 170 ? -4.220 70.123 11.552 1.00 68.16 ? 170 ASN A CB 1 ATOM 1353 C CG . ASN A 1 170 ? -4.020 70.368 13.035 1.00 70.28 ? 170 ASN A CG 1 ATOM 1354 O OD1 . ASN A 1 170 ? -3.301 71.286 13.435 1.00 72.41 ? 170 ASN A OD1 1 ATOM 1355 N ND2 . ASN A 1 170 ? -4.660 69.550 13.861 1.00 71.37 ? 170 ASN A ND2 1 ATOM 1356 N N . GLY A 1 171 ? -1.767 68.930 9.193 1.00 63.19 ? 171 GLY A N 1 ATOM 1357 C CA . GLY A 1 171 ? -1.617 68.116 8.001 1.00 60.29 ? 171 GLY A CA 1 ATOM 1358 C C . GLY A 1 171 ? -2.554 66.931 7.899 1.00 58.57 ? 171 GLY A C 1 ATOM 1359 O O . GLY A 1 171 ? -2.981 66.370 8.913 1.00 58.03 ? 171 GLY A O 1 ATOM 1360 N N . MET A 1 172 ? -2.877 66.546 6.667 1.00 56.67 ? 172 MET A N 1 ATOM 1361 C CA . MET A 1 172 ? -3.754 65.410 6.459 1.00 54.50 ? 172 MET A CA 1 ATOM 1362 C C . MET A 1 172 ? -3.833 64.882 5.039 1.00 53.20 ? 172 MET A C 1 ATOM 1363 O O . MET A 1 172 ? -3.451 65.549 4.076 1.00 52.04 ? 172 MET A O 1 ATOM 1364 C CB . MET A 1 172 ? -5.156 65.733 6.956 1.00 53.56 ? 172 MET A CB 1 ATOM 1365 C CG . MET A 1 172 ? -5.720 67.013 6.420 1.00 52.70 ? 172 MET A CG 1 ATOM 1366 S SD . MET A 1 172 ? -7.250 67.310 7.276 1.00 55.05 ? 172 MET A SD 1 ATOM 1367 C CE . MET A 1 172 ? -6.618 67.709 8.927 1.00 53.79 ? 172 MET A CE 1 ATOM 1368 N N . ALA A 1 173 ? -4.334 63.655 4.946 1.00 52.38 ? 173 ALA A N 1 ATOM 1369 C CA . ALA A 1 173 ? -4.512 62.947 3.692 1.00 51.33 ? 173 ALA A CA 1 ATOM 1370 C C . ALA A 1 173 ? -5.995 62.977 3.333 1.00 50.78 ? 173 ALA A C 1 ATOM 1371 O O . ALA A 1 173 ? -6.781 62.170 3.840 1.00 50.21 ? 173 ALA A O 1 ATOM 1372 C CB . ALA A 1 173 ? -4.043 61.504 3.846 1.00 50.66 ? 173 ALA A CB 1 ATOM 1373 N N . PHE A 1 174 ? -6.375 63.920 2.476 1.00 49.53 ? 174 PHE A N 1 ATOM 1374 C CA . PHE A 1 174 ? -7.761 64.051 2.048 1.00 48.21 ? 174 PHE A CA 1 ATOM 1375 C C . PHE A 1 174 ? -8.124 62.862 1.177 1.00 48.16 ? 174 PHE A C 1 ATOM 1376 O O . PHE A 1 174 ? -7.401 62.531 0.242 1.00 48.19 ? 174 PHE A O 1 ATOM 1377 C CB . PHE A 1 174 ? -7.942 65.345 1.264 1.00 47.28 ? 174 PHE A CB 1 ATOM 1378 C CG . PHE A 1 174 ? -7.748 66.581 2.088 1.00 47.38 ? 174 PHE A CG 1 ATOM 1379 C CD1 . PHE A 1 174 ? -8.611 66.869 3.143 1.00 47.24 ? 174 PHE A CD1 1 ATOM 1380 C CD2 . PHE A 1 174 ? -6.702 67.463 1.812 1.00 47.68 ? 174 PHE A CD2 1 ATOM 1381 C CE1 . PHE A 1 174 ? -8.440 68.028 3.916 1.00 47.65 ? 174 PHE A CE1 1 ATOM 1382 C CE2 . PHE A 1 174 ? -6.518 68.626 2.577 1.00 47.03 ? 174 PHE A CE2 1 ATOM 1383 C CZ . PHE A 1 174 ? -7.391 68.907 3.632 1.00 46.99 ? 174 PHE A CZ 1 ATOM 1384 N N . LEU A 1 175 ? -9.250 62.225 1.480 1.00 48.11 ? 175 LEU A N 1 ATOM 1385 C CA . LEU A 1 175 ? -9.691 61.051 0.733 1.00 47.71 ? 175 LEU A CA 1 ATOM 1386 C C . LEU A 1 175 ? -10.770 61.384 -0.290 1.00 48.77 ? 175 LEU A C 1 ATOM 1387 O O . LEU A 1 175 ? -11.727 62.085 0.030 1.00 51.00 ? 175 LEU A O 1 ATOM 1388 C CB . LEU A 1 175 ? -10.224 60.003 1.713 1.00 45.95 ? 175 LEU A CB 1 ATOM 1389 C CG . LEU A 1 175 ? -10.602 58.634 1.154 1.00 45.43 ? 175 LEU A CG 1 ATOM 1390 C CD1 . LEU A 1 175 ? -9.379 57.985 0.539 1.00 46.30 ? 175 LEU A CD1 1 ATOM 1391 C CD2 . LEU A 1 175 ? -11.147 57.758 2.258 1.00 45.69 ? 175 LEU A CD2 1 ATOM 1392 N N . TYR A 1 176 ? -10.614 60.887 -1.517 1.00 48.28 ? 176 TYR A N 1 ATOM 1393 C CA . TYR A 1 176 ? -11.603 61.114 -2.570 1.00 47.12 ? 176 TYR A CA 1 ATOM 1394 C C . TYR A 1 176 ? -12.068 59.800 -3.173 1.00 47.51 ? 176 TYR A C 1 ATOM 1395 O O . TYR A 1 176 ? -11.351 58.797 -3.123 1.00 47.35 ? 176 TYR A O 1 ATOM 1396 C CB . TYR A 1 176 ? -11.040 61.995 -3.676 1.00 46.13 ? 176 TYR A CB 1 ATOM 1397 C CG . TYR A 1 176 ? -10.875 63.428 -3.259 1.00 47.67 ? 176 TYR A CG 1 ATOM 1398 C CD1 . TYR A 1 176 ? -9.836 63.820 -2.419 1.00 47.24 ? 176 TYR A CD1 1 ATOM 1399 C CD2 . TYR A 1 176 ? -11.764 64.399 -3.700 1.00 48.12 ? 176 TYR A CD2 1 ATOM 1400 C CE1 . TYR A 1 176 ? -9.683 65.152 -2.033 1.00 47.50 ? 176 TYR A CE1 1 ATOM 1401 C CE2 . TYR A 1 176 ? -11.624 65.734 -3.318 1.00 48.45 ? 176 TYR A CE2 1 ATOM 1402 C CZ . TYR A 1 176 ? -10.579 66.106 -2.485 1.00 47.98 ? 176 TYR A CZ 1 ATOM 1403 O OH . TYR A 1 176 ? -10.423 67.430 -2.125 1.00 47.22 ? 176 TYR A OH 1 ATOM 1404 N N . GLN A 1 177 ? -13.269 59.806 -3.743 1.00 47.88 ? 177 GLN A N 1 ATOM 1405 C CA . GLN A 1 177 ? -13.826 58.605 -4.356 1.00 48.68 ? 177 GLN A CA 1 ATOM 1406 C C . GLN A 1 177 ? -14.410 58.859 -5.737 1.00 48.42 ? 177 GLN A C 1 ATOM 1407 O O . GLN A 1 177 ? -14.872 59.959 -6.043 1.00 48.36 ? 177 GLN A O 1 ATOM 1408 C CB . GLN A 1 177 ? -14.904 58.016 -3.457 1.00 48.77 ? 177 GLN A CB 1 ATOM 1409 C CG . GLN A 1 177 ? -14.373 57.518 -2.146 1.00 52.08 ? 177 GLN A CG 1 ATOM 1410 C CD . GLN A 1 177 ? -15.472 57.147 -1.183 1.00 53.83 ? 177 GLN A CD 1 ATOM 1411 O OE1 . GLN A 1 177 ? -16.293 57.985 -0.812 1.00 53.90 ? 177 GLN A OE1 1 ATOM 1412 N NE2 . GLN A 1 177 ? -15.496 55.882 -0.770 1.00 55.23 ? 177 GLN A NE2 1 ATOM 1413 N N . SER A 1 178 ? -14.391 57.828 -6.571 1.00 47.68 ? 178 SER A N 1 ATOM 1414 C CA . SER A 1 178 ? -14.935 57.943 -7.914 1.00 47.79 ? 178 SER A CA 1 ATOM 1415 C C . SER A 1 178 ? -15.234 56.555 -8.465 1.00 48.13 ? 178 SER A C 1 ATOM 1416 O O . SER A 1 178 ? -14.746 55.555 -7.934 1.00 48.52 ? 178 SER A O 1 ATOM 1417 C CB . SER A 1 178 ? -13.938 58.664 -8.814 1.00 47.21 ? 178 SER A CB 1 ATOM 1418 O OG . SER A 1 178 ? -14.454 58.788 -10.122 1.00 49.90 ? 178 SER A OG 1 ATOM 1419 N N . THR A 1 179 ? -16.058 56.486 -9.508 1.00 47.68 ? 179 THR A N 1 ATOM 1420 C CA . THR A 1 179 ? -16.386 55.200 -10.120 1.00 47.64 ? 179 THR A CA 1 ATOM 1421 C C . THR A 1 179 ? -15.871 55.162 -11.549 1.00 47.31 ? 179 THR A C 1 ATOM 1422 O O . THR A 1 179 ? -15.705 54.088 -12.122 1.00 48.24 ? 179 THR A O 1 ATOM 1423 C CB . THR A 1 179 ? -17.909 54.934 -10.151 1.00 47.55 ? 179 THR A CB 1 ATOM 1424 O OG1 . THR A 1 179 ? -18.605 56.178 -10.256 1.00 48.83 ? 179 THR A OG1 1 ATOM 1425 C CG2 . THR A 1 179 ? -18.361 54.195 -8.908 1.00 46.80 ? 179 THR A CG2 1 ATOM 1426 N N . ASP A 1 180 ? -15.605 56.343 -12.102 1.00 46.55 ? 180 ASP A N 1 ATOM 1427 C CA . ASP A 1 180 ? -15.130 56.493 -13.473 1.00 46.31 ? 180 ASP A CA 1 ATOM 1428 C C . ASP A 1 180 ? -13.731 57.098 -13.557 1.00 45.69 ? 180 ASP A C 1 ATOM 1429 O O . ASP A 1 180 ? -13.190 57.281 -14.646 1.00 45.38 ? 180 ASP A O 1 ATOM 1430 C CB . ASP A 1 180 ? -16.101 57.382 -14.245 1.00 48.32 ? 180 ASP A CB 1 ATOM 1431 C CG . ASP A 1 180 ? -16.093 58.818 -13.747 1.00 49.45 ? 180 ASP A CG 1 ATOM 1432 O OD1 . ASP A 1 180 ? -16.088 59.023 -12.516 1.00 50.85 ? 180 ASP A OD1 1 ATOM 1433 O OD2 . ASP A 1 180 ? -16.098 59.743 -14.586 1.00 50.54 ? 180 ASP A OD2 1 ATOM 1434 N N . PHE A 1 181 ? -13.154 57.419 -12.406 1.00 45.13 ? 181 PHE A N 1 ATOM 1435 C CA . PHE A 1 181 ? -11.813 58.002 -12.336 1.00 44.96 ? 181 PHE A CA 1 ATOM 1436 C C . PHE A 1 181 ? -11.753 59.440 -12.853 1.00 44.93 ? 181 PHE A C 1 ATOM 1437 O O . PHE A 1 181 ? -10.666 60.014 -12.984 1.00 44.23 ? 181 PHE A O 1 ATOM 1438 C CB . PHE A 1 181 ? -10.803 57.146 -13.116 1.00 43.58 ? 181 PHE A CB 1 ATOM 1439 C CG . PHE A 1 181 ? -9.465 57.045 -12.447 1.00 42.01 ? 181 PHE A CG 1 ATOM 1440 C CD1 . PHE A 1 181 ? -9.301 56.247 -11.317 1.00 42.11 ? 181 PHE A CD1 1 ATOM 1441 C CD2 . PHE A 1 181 ? -8.381 57.781 -12.908 1.00 42.62 ? 181 PHE A CD2 1 ATOM 1442 C CE1 . PHE A 1 181 ? -8.072 56.191 -10.644 1.00 42.16 ? 181 PHE A CE1 1 ATOM 1443 C CE2 . PHE A 1 181 ? -7.146 57.735 -12.242 1.00 42.97 ? 181 PHE A CE2 1 ATOM 1444 C CZ . PHE A 1 181 ? -6.994 56.937 -11.111 1.00 41.79 ? 181 PHE A CZ 1 ATOM 1445 N N . VAL A 1 182 ? -12.914 60.022 -13.144 1.00 44.48 ? 182 VAL A N 1 ATOM 1446 C CA . VAL A 1 182 ? -12.954 61.393 -13.638 1.00 44.46 ? 182 VAL A CA 1 ATOM 1447 C C . VAL A 1 182 ? -13.738 62.277 -12.678 1.00 45.77 ? 182 VAL A C 1 ATOM 1448 O O . VAL A 1 182 ? -13.360 63.420 -12.423 1.00 46.31 ? 182 VAL A O 1 ATOM 1449 C CB . VAL A 1 182 ? -13.592 61.477 -15.049 1.00 42.31 ? 182 VAL A CB 1 ATOM 1450 C CG1 . VAL A 1 182 ? -13.455 62.882 -15.598 1.00 40.61 ? 182 VAL A CG1 1 ATOM 1451 C CG2 . VAL A 1 182 ? -12.917 60.498 -15.988 1.00 41.85 ? 182 VAL A CG2 1 ATOM 1452 N N . ASN A 1 183 ? -14.831 61.749 -12.142 1.00 47.37 ? 183 ASN A N 1 ATOM 1453 C CA . ASN A 1 183 ? -15.642 62.514 -11.206 1.00 49.66 ? 183 ASN A CA 1 ATOM 1454 C C . ASN A 1 183 ? -15.323 62.065 -9.800 1.00 50.56 ? 183 ASN A C 1 ATOM 1455 O O . ASN A 1 183 ? -15.757 60.999 -9.360 1.00 51.86 ? 183 ASN A O 1 ATOM 1456 C CB . ASN A 1 183 ? -17.126 62.314 -11.495 1.00 50.53 ? 183 ASN A CB 1 ATOM 1457 C CG . ASN A 1 183 ? -17.462 62.587 -12.940 1.00 52.94 ? 183 ASN A CG 1 ATOM 1458 O OD1 . ASN A 1 183 ? -17.154 63.660 -13.465 1.00 53.20 ? 183 ASN A OD1 1 ATOM 1459 N ND2 . ASN A 1 183 ? -18.088 61.615 -13.599 1.00 54.14 ? 183 ASN A ND2 1 ATOM 1460 N N . TRP A 1 184 ? -14.559 62.890 -9.097 1.00 50.43 ? 184 TRP A N 1 ATOM 1461 C CA . TRP A 1 184 ? -14.152 62.589 -7.735 1.00 49.92 ? 184 TRP A CA 1 ATOM 1462 C C . TRP A 1 184 ? -14.976 63.296 -6.665 1.00 50.58 ? 184 TRP A C 1 ATOM 1463 O O . TRP A 1 184 ? -15.195 64.502 -6.734 1.00 50.54 ? 184 TRP A O 1 ATOM 1464 C CB . TRP A 1 184 ? -12.680 62.954 -7.558 1.00 48.83 ? 184 TRP A CB 1 ATOM 1465 C CG . TRP A 1 184 ? -11.787 62.208 -8.475 1.00 45.40 ? 184 TRP A CG 1 ATOM 1466 C CD1 . TRP A 1 184 ? -11.374 62.589 -9.715 1.00 43.92 ? 184 TRP A CD1 1 ATOM 1467 C CD2 . TRP A 1 184 ? -11.242 60.912 -8.246 1.00 44.45 ? 184 TRP A CD2 1 ATOM 1468 N NE1 . TRP A 1 184 ? -10.603 61.603 -10.279 1.00 43.89 ? 184 TRP A NE1 1 ATOM 1469 C CE2 . TRP A 1 184 ? -10.507 60.557 -9.393 1.00 44.53 ? 184 TRP A CE2 1 ATOM 1470 C CE3 . TRP A 1 184 ? -11.309 60.005 -7.176 1.00 42.74 ? 184 TRP A CE3 1 ATOM 1471 C CZ2 . TRP A 1 184 ? -9.837 59.334 -9.506 1.00 43.78 ? 184 TRP A CZ2 1 ATOM 1472 C CZ3 . TRP A 1 184 ? -10.649 58.792 -7.284 1.00 41.57 ? 184 TRP A CZ3 1 ATOM 1473 C CH2 . TRP A 1 184 ? -9.921 58.467 -8.442 1.00 43.08 ? 184 TRP A CH2 1 ATOM 1474 N N . LYS A 1 185 ? -15.425 62.534 -5.673 1.00 51.86 ? 185 LYS A N 1 ATOM 1475 C CA . LYS A 1 185 ? -16.197 63.088 -4.567 1.00 54.29 ? 185 LYS A CA 1 ATOM 1476 C C . LYS A 1 185 ? -15.309 63.035 -3.325 1.00 54.94 ? 185 LYS A C 1 ATOM 1477 O O . LYS A 1 185 ? -14.741 61.989 -3.008 1.00 55.49 ? 185 LYS A O 1 ATOM 1478 C CB . LYS A 1 185 ? -17.458 62.254 -4.312 1.00 55.88 ? 185 LYS A CB 1 ATOM 1479 C CG . LYS A 1 185 ? -18.348 62.027 -5.523 1.00 59.17 ? 185 LYS A CG 1 ATOM 1480 C CD . LYS A 1 185 ? -19.094 63.289 -5.941 1.00 62.39 ? 185 LYS A CD 1 ATOM 1481 C CE . LYS A 1 185 ? -20.077 63.000 -7.082 1.00 64.17 ? 185 LYS A CE 1 ATOM 1482 N NZ . LYS A 1 185 ? -19.395 62.497 -8.317 1.00 64.94 ? 185 LYS A NZ 1 ATOM 1483 N N . ARG A 1 186 ? -15.178 64.159 -2.631 1.00 55.78 ? 186 ARG A N 1 ATOM 1484 C CA . ARG A 1 186 ? -14.368 64.203 -1.422 1.00 56.42 ? 186 ARG A CA 1 ATOM 1485 C C . ARG A 1 186 ? -15.109 63.518 -0.274 1.00 56.11 ? 186 ARG A C 1 ATOM 1486 O O . ARG A 1 186 ? -16.313 63.695 -0.111 1.00 55.57 ? 186 ARG A O 1 ATOM 1487 C CB . ARG A 1 186 ? -14.060 65.650 -1.049 1.00 57.68 ? 186 ARG A CB 1 ATOM 1488 C CG . ARG A 1 186 ? -13.339 65.790 0.266 1.00 60.91 ? 186 ARG A CG 1 ATOM 1489 C CD . ARG A 1 186 ? -13.159 67.245 0.673 1.00 64.73 ? 186 ARG A CD 1 ATOM 1490 N NE . ARG A 1 186 ? -12.681 67.337 2.048 1.00 69.47 ? 186 ARG A NE 1 ATOM 1491 C CZ . ARG A 1 186 ? -13.419 67.051 3.120 1.00 71.42 ? 186 ARG A CZ 1 ATOM 1492 N NH1 . ARG A 1 186 ? -14.682 66.667 2.972 1.00 71.05 ? 186 ARG A NH1 1 ATOM 1493 N NH2 . ARG A 1 186 ? -12.886 67.116 4.341 1.00 71.65 ? 186 ARG A NH2 1 ATOM 1494 N N . TYR A 1 187 ? -14.390 62.724 0.512 1.00 56.93 ? 187 TYR A N 1 ATOM 1495 C CA . TYR A 1 187 ? -14.988 62.022 1.645 1.00 57.69 ? 187 TYR A CA 1 ATOM 1496 C C . TYR A 1 187 ? -14.860 62.941 2.849 1.00 59.18 ? 187 TYR A C 1 ATOM 1497 O O . TYR A 1 187 ? -13.787 63.479 3.107 1.00 59.75 ? 187 TYR A O 1 ATOM 1498 C CB . TYR A 1 187 ? -14.242 60.714 1.897 1.00 56.25 ? 187 TYR A CB 1 ATOM 1499 C CG . TYR A 1 187 ? -14.832 59.850 2.982 1.00 55.11 ? 187 TYR A CG 1 ATOM 1500 C CD1 . TYR A 1 187 ? -15.719 58.819 2.683 1.00 54.07 ? 187 TYR A CD1 1 ATOM 1501 C CD2 . TYR A 1 187 ? -14.469 60.035 4.309 1.00 55.68 ? 187 TYR A CD2 1 ATOM 1502 C CE1 . TYR A 1 187 ? -16.221 57.985 3.687 1.00 53.68 ? 187 TYR A CE1 1 ATOM 1503 C CE2 . TYR A 1 187 ? -14.963 59.214 5.318 1.00 55.36 ? 187 TYR A CE2 1 ATOM 1504 C CZ . TYR A 1 187 ? -15.835 58.192 5.006 1.00 54.49 ? 187 TYR A CZ 1 ATOM 1505 O OH . TYR A 1 187 ? -16.294 57.388 6.030 1.00 53.45 ? 187 TYR A OH 1 ATOM 1506 N N . ASP A 1 188 ? -15.957 63.111 3.578 1.00 61.55 ? 188 ASP A N 1 ATOM 1507 C CA . ASP A 1 188 ? -16.017 63.991 4.746 1.00 64.22 ? 188 ASP A CA 1 ATOM 1508 C C . ASP A 1 188 ? -14.783 64.067 5.652 1.00 62.69 ? 188 ASP A C 1 ATOM 1509 O O . ASP A 1 188 ? -14.348 65.170 6.005 1.00 62.76 ? 188 ASP A O 1 ATOM 1510 C CB . ASP A 1 188 ? -17.236 63.637 5.592 1.00 69.85 ? 188 ASP A CB 1 ATOM 1511 C CG . ASP A 1 188 ? -17.269 62.172 5.968 1.00 75.98 ? 188 ASP A CG 1 ATOM 1512 O OD1 . ASP A 1 188 ? -17.433 61.330 5.050 1.00 78.53 ? 188 ASP A OD1 1 ATOM 1513 O OD2 . ASP A 1 188 ? -17.120 61.864 7.177 1.00 78.96 ? 188 ASP A OD2 1 ATOM 1514 N N . GLN A 1 189 ? -14.229 62.921 6.050 1.00 59.71 ? 189 GLN A N 1 ATOM 1515 C CA . GLN A 1 189 ? -13.047 62.937 6.911 1.00 57.84 ? 189 GLN A CA 1 ATOM 1516 C C . GLN A 1 189 ? -11.807 62.489 6.155 1.00 54.59 ? 189 GLN A C 1 ATOM 1517 O O . GLN A 1 189 ? -11.911 61.830 5.128 1.00 54.99 ? 189 GLN A O 1 ATOM 1518 C CB . GLN A 1 189 ? -13.252 62.046 8.135 1.00 59.88 ? 189 GLN A CB 1 ATOM 1519 C CG . GLN A 1 189 ? -13.285 60.568 7.838 1.00 65.73 ? 189 GLN A CG 1 ATOM 1520 C CD . GLN A 1 189 ? -13.495 59.727 9.093 1.00 69.37 ? 189 GLN A CD 1 ATOM 1521 O OE1 . GLN A 1 189 ? -13.614 58.497 9.022 1.00 71.08 ? 189 GLN A OE1 1 ATOM 1522 N NE2 . GLN A 1 189 ? -13.541 60.390 10.250 1.00 69.88 ? 189 GLN A NE2 1 ATOM 1523 N N . PRO A 1 190 ? -10.613 62.863 6.642 1.00 51.64 ? 190 PRO A N 1 ATOM 1524 C CA . PRO A 1 190 ? -9.383 62.464 5.963 1.00 49.98 ? 190 PRO A CA 1 ATOM 1525 C C . PRO A 1 190 ? -9.082 61.027 6.327 1.00 48.72 ? 190 PRO A C 1 ATOM 1526 O O . PRO A 1 190 ? -9.644 60.507 7.287 1.00 48.10 ? 190 PRO A O 1 ATOM 1527 C CB . PRO A 1 190 ? -8.356 63.435 6.527 1.00 48.74 ? 190 PRO A CB 1 ATOM 1528 C CG . PRO A 1 190 ? -8.805 63.579 7.915 1.00 48.07 ? 190 PRO A CG 1 ATOM 1529 C CD . PRO A 1 190 ? -10.304 63.726 7.792 1.00 49.78 ? 190 PRO A CD 1 ATOM 1530 N N . LEU A 1 191 ? -8.211 60.384 5.560 1.00 47.84 ? 191 LEU A N 1 ATOM 1531 C CA . LEU A 1 191 ? -7.865 59.002 5.838 1.00 47.75 ? 191 LEU A CA 1 ATOM 1532 C C . LEU A 1 191 ? -6.957 58.979 7.063 1.00 49.68 ? 191 LEU A C 1 ATOM 1533 O O . LEU A 1 191 ? -6.900 57.987 7.792 1.00 51.04 ? 191 LEU A O 1 ATOM 1534 C CB . LEU A 1 191 ? -7.155 58.371 4.637 1.00 44.49 ? 191 LEU A CB 1 ATOM 1535 C CG . LEU A 1 191 ? -6.969 56.852 4.684 1.00 41.89 ? 191 LEU A CG 1 ATOM 1536 C CD1 . LEU A 1 191 ? -8.313 56.168 4.643 1.00 38.53 ? 191 LEU A CD1 1 ATOM 1537 C CD2 . LEU A 1 191 ? -6.115 56.405 3.510 1.00 41.60 ? 191 LEU A CD2 1 ATOM 1538 N N . SER A 1 192 ? -6.256 60.084 7.296 1.00 50.99 ? 192 SER A N 1 ATOM 1539 C CA . SER A 1 192 ? -5.360 60.170 8.440 1.00 51.58 ? 192 SER A CA 1 ATOM 1540 C C . SER A 1 192 ? -4.905 61.608 8.682 1.00 52.64 ? 192 SER A C 1 ATOM 1541 O O . SER A 1 192 ? -4.782 62.387 7.736 1.00 51.83 ? 192 SER A O 1 ATOM 1542 C CB . SER A 1 192 ? -4.153 59.266 8.215 1.00 50.64 ? 192 SER A CB 1 ATOM 1543 O OG . SER A 1 192 ? -3.445 59.091 9.422 1.00 51.76 ? 192 SER A OG 1 ATOM 1544 N N . SER A 1 193 ? -4.658 61.950 9.948 1.00 54.72 ? 193 SER A N 1 ATOM 1545 C CA . SER A 1 193 ? -4.234 63.299 10.329 1.00 56.05 ? 193 SER A CA 1 ATOM 1546 C C . SER A 1 193 ? -3.104 63.369 11.339 1.00 56.50 ? 193 SER A C 1 ATOM 1547 O O . SER A 1 193 ? -2.638 62.350 11.840 1.00 57.81 ? 193 SER A O 1 ATOM 1548 C CB . SER A 1 193 ? -5.411 64.080 10.897 1.00 56.35 ? 193 SER A CB 1 ATOM 1549 O OG . SER A 1 193 ? -6.250 64.536 9.857 1.00 59.79 ? 193 SER A OG 1 ATOM 1550 N N . ALA A 1 194 ? -2.686 64.598 11.632 1.00 56.47 ? 194 ALA A N 1 ATOM 1551 C CA . ALA A 1 194 ? -1.619 64.884 12.589 1.00 56.92 ? 194 ALA A CA 1 ATOM 1552 C C . ALA A 1 194 ? -1.660 66.377 12.895 1.00 57.53 ? 194 ALA A C 1 ATOM 1553 O O . ALA A 1 194 ? -1.735 67.202 11.985 1.00 57.33 ? 194 ALA A O 1 ATOM 1554 C CB . ALA A 1 194 ? -0.261 64.503 12.005 1.00 55.73 ? 194 ALA A CB 1 ATOM 1555 N N . ASP A 1 195 ? -1.606 66.729 14.173 1.00 58.47 ? 195 ASP A N 1 ATOM 1556 C CA . ASP A 1 195 ? -1.662 68.134 14.566 1.00 59.65 ? 195 ASP A CA 1 ATOM 1557 C C . ASP A 1 195 ? -0.399 68.945 14.287 1.00 58.35 ? 195 ASP A C 1 ATOM 1558 O O . ASP A 1 195 ? 0.716 68.461 14.461 1.00 57.62 ? 195 ASP A O 1 ATOM 1559 C CB . ASP A 1 195 ? -2.015 68.247 16.051 1.00 63.68 ? 195 ASP A CB 1 ATOM 1560 C CG . ASP A 1 195 ? -3.454 67.859 16.341 1.00 67.11 ? 195 ASP A CG 1 ATOM 1561 O OD1 . ASP A 1 195 ? -3.871 67.940 17.519 1.00 69.54 ? 195 ASP A OD1 1 ATOM 1562 O OD2 . ASP A 1 195 ? -4.170 67.474 15.392 1.00 69.90 ? 195 ASP A OD2 1 ATOM 1563 N N . ALA A 1 196 ? -0.599 70.188 13.858 1.00 57.72 ? 196 ALA A N 1 ATOM 1564 C CA . ALA A 1 196 ? 0.483 71.128 13.550 1.00 58.15 ? 196 ALA A CA 1 ATOM 1565 C C . ALA A 1 196 ? 1.738 70.529 12.934 1.00 57.89 ? 196 ALA A C 1 ATOM 1566 O O . ALA A 1 196 ? 2.833 70.704 13.467 1.00 58.73 ? 196 ALA A O 1 ATOM 1567 C CB . ALA A 1 196 ? 0.864 71.909 14.802 1.00 58.20 ? 196 ALA A CB 1 ATOM 1568 N N . THR A 1 197 ? 1.587 69.839 11.810 1.00 56.78 ? 197 THR A N 1 ATOM 1569 C CA . THR A 1 197 ? 2.732 69.240 11.139 1.00 55.37 ? 197 THR A CA 1 ATOM 1570 C C . THR A 1 197 ? 2.973 70.000 9.853 1.00 54.32 ? 197 THR A C 1 ATOM 1571 O O . THR A 1 197 ? 4.009 69.846 9.207 1.00 55.10 ? 197 THR A O 1 ATOM 1572 C CB . THR A 1 197 ? 2.472 67.774 10.775 1.00 55.56 ? 197 THR A CB 1 ATOM 1573 O OG1 . THR A 1 197 ? 1.366 67.704 9.866 1.00 55.38 ? 197 THR A OG1 1 ATOM 1574 C CG2 . THR A 1 197 ? 2.163 66.957 12.021 1.00 56.22 ? 197 THR A CG2 1 ATOM 1575 N N . GLY A 1 198 ? 2.005 70.830 9.488 1.00 52.93 ? 198 GLY A N 1 ATOM 1576 C CA . GLY A 1 198 ? 2.122 71.590 8.262 1.00 51.81 ? 198 GLY A CA 1 ATOM 1577 C C . GLY A 1 198 ? 1.584 70.724 7.147 1.00 51.02 ? 198 GLY A C 1 ATOM 1578 O O . GLY A 1 198 ? 1.124 69.608 7.405 1.00 50.75 ? 198 GLY A O 1 ATOM 1579 N N . THR A 1 199 ? 1.650 71.215 5.914 1.00 50.40 ? 199 THR A N 1 ATOM 1580 C CA . THR A 1 199 ? 1.134 70.460 4.776 1.00 48.81 ? 199 THR A CA 1 ATOM 1581 C C . THR A 1 199 ? 1.745 69.060 4.657 1.00 47.84 ? 199 THR A C 1 ATOM 1582 O O . THR A 1 199 ? 2.951 68.878 4.846 1.00 47.65 ? 199 THR A O 1 ATOM 1583 C CB . THR A 1 199 ? 1.381 71.202 3.447 1.00 48.62 ? 199 THR A CB 1 ATOM 1584 O OG1 . THR A 1 199 ? 0.912 72.552 3.544 1.00 48.41 ? 199 THR A OG1 1 ATOM 1585 C CG2 . THR A 1 199 ? 0.640 70.511 2.327 1.00 47.99 ? 199 THR A CG2 1 ATOM 1586 N N . TRP A 1 200 ? 0.892 68.080 4.361 1.00 45.91 ? 200 TRP A N 1 ATOM 1587 C CA . TRP A 1 200 ? 1.300 66.688 4.169 1.00 43.24 ? 200 TRP A CA 1 ATOM 1588 C C . TRP A 1 200 ? 1.637 66.533 2.697 1.00 42.93 ? 200 TRP A C 1 ATOM 1589 O O . TRP A 1 200 ? 0.837 66.876 1.835 1.00 42.16 ? 200 TRP A O 1 ATOM 1590 C CB . TRP A 1 200 ? 0.157 65.741 4.518 1.00 41.74 ? 200 TRP A CB 1 ATOM 1591 C CG . TRP A 1 200 ? 0.242 65.178 5.886 1.00 41.63 ? 200 TRP A CG 1 ATOM 1592 C CD1 . TRP A 1 200 ? 0.837 65.750 6.972 1.00 41.58 ? 200 TRP A CD1 1 ATOM 1593 C CD2 . TRP A 1 200 ? -0.329 63.944 6.341 1.00 40.75 ? 200 TRP A CD2 1 ATOM 1594 N NE1 . TRP A 1 200 ? 0.670 64.949 8.080 1.00 41.43 ? 200 TRP A NE1 1 ATOM 1595 C CE2 . TRP A 1 200 ? -0.046 63.835 7.721 1.00 40.67 ? 200 TRP A CE2 1 ATOM 1596 C CE3 . TRP A 1 200 ? -1.062 62.923 5.718 1.00 38.82 ? 200 TRP A CE3 1 ATOM 1597 C CZ2 . TRP A 1 200 ? -0.462 62.743 8.490 1.00 39.45 ? 200 TRP A CZ2 1 ATOM 1598 C CZ3 . TRP A 1 200 ? -1.477 61.834 6.485 1.00 39.30 ? 200 TRP A CZ3 1 ATOM 1599 C CH2 . TRP A 1 200 ? -1.176 61.758 7.857 1.00 38.91 ? 200 TRP A CH2 1 ATOM 1600 N N . GLN A 1 201 ? 2.809 65.991 2.403 1.00 42.99 ? 201 GLN A N 1 ATOM 1601 C CA . GLN A 1 201 ? 3.223 65.847 1.020 1.00 42.58 ? 201 GLN A CA 1 ATOM 1602 C C . GLN A 1 201 ? 3.462 64.423 0.528 1.00 42.61 ? 201 GLN A C 1 ATOM 1603 O O . GLN A 1 201 ? 3.921 63.564 1.278 1.00 43.63 ? 201 GLN A O 1 ATOM 1604 C CB . GLN A 1 201 ? 4.480 66.671 0.811 1.00 41.56 ? 201 GLN A CB 1 ATOM 1605 C CG . GLN A 1 201 ? 4.281 68.119 1.129 1.00 42.59 ? 201 GLN A CG 1 ATOM 1606 C CD . GLN A 1 201 ? 5.571 68.878 1.068 1.00 44.25 ? 201 GLN A CD 1 ATOM 1607 O OE1 . GLN A 1 201 ? 5.587 70.107 1.000 1.00 46.33 ? 201 GLN A OE1 1 ATOM 1608 N NE2 . GLN A 1 201 ? 6.676 68.149 1.094 1.00 45.79 ? 201 GLN A NE2 1 ATOM 1609 N N . CYS A 1 202 ? 3.146 64.189 -0.743 1.00 42.03 ? 202 CYS A N 1 ATOM 1610 C CA . CYS A 1 202 ? 3.349 62.893 -1.376 1.00 41.86 ? 202 CYS A CA 1 ATOM 1611 C C . CYS A 1 202 ? 2.786 61.717 -0.588 1.00 42.10 ? 202 CYS A C 1 ATOM 1612 O O . CYS A 1 202 ? 3.443 60.677 -0.448 1.00 43.03 ? 202 CYS A O 1 ATOM 1613 C CB . CYS A 1 202 ? 4.843 62.673 -1.609 1.00 41.66 ? 202 CYS A CB 1 ATOM 1614 S SG . CYS A 1 202 ? 5.594 63.892 -2.701 1.00 40.72 ? 202 CYS A SG 1 ATOM 1615 N N . PRO A 1 203 ? 1.555 61.849 -0.076 1.00 40.59 ? 203 PRO A N 1 ATOM 1616 C CA . PRO A 1 203 ? 0.998 60.729 0.687 1.00 38.87 ? 203 PRO A CA 1 ATOM 1617 C C . PRO A 1 203 ? 0.965 59.468 -0.155 1.00 37.96 ? 203 PRO A C 1 ATOM 1618 O O . PRO A 1 203 ? 0.720 59.533 -1.356 1.00 39.74 ? 203 PRO A O 1 ATOM 1619 C CB . PRO A 1 203 ? -0.393 61.219 1.042 1.00 37.91 ? 203 PRO A CB 1 ATOM 1620 C CG . PRO A 1 203 ? -0.749 62.057 -0.159 1.00 39.56 ? 203 PRO A CG 1 ATOM 1621 C CD . PRO A 1 203 ? 0.517 62.847 -0.387 1.00 39.33 ? 203 PRO A CD 1 ATOM 1622 N N . ASP A 1 204 ? 1.228 58.330 0.474 1.00 36.06 ? 204 ASP A N 1 ATOM 1623 C CA . ASP A 1 204 ? 1.214 57.040 -0.207 1.00 35.57 ? 204 ASP A CA 1 ATOM 1624 C C . ASP A 1 204 ? 0.423 56.086 0.693 1.00 36.05 ? 204 ASP A C 1 ATOM 1625 O O . ASP A 1 204 ? 0.629 56.054 1.902 1.00 37.29 ? 204 ASP A O 1 ATOM 1626 C CB . ASP A 1 204 ? 2.647 56.532 -0.391 1.00 35.75 ? 204 ASP A CB 1 ATOM 1627 C CG . ASP A 1 204 ? 2.752 55.403 -1.409 1.00 35.21 ? 204 ASP A CG 1 ATOM 1628 O OD1 . ASP A 1 204 ? 1.695 54.857 -1.796 1.00 35.99 ? 204 ASP A OD1 1 ATOM 1629 O OD2 . ASP A 1 204 ? 3.890 55.061 -1.813 1.00 31.93 ? 204 ASP A OD2 1 ATOM 1630 N N . PHE A 1 205 ? -0.489 55.318 0.113 1.00 36.46 ? 205 PHE A N 1 ATOM 1631 C CA . PHE A 1 205 ? -1.297 54.383 0.891 1.00 36.12 ? 205 PHE A CA 1 ATOM 1632 C C . PHE A 1 205 ? -1.342 53.075 0.122 1.00 35.70 ? 205 PHE A C 1 ATOM 1633 O O . PHE A 1 205 ? -1.836 53.032 -1.001 1.00 36.57 ? 205 PHE A O 1 ATOM 1634 C CB . PHE A 1 205 ? -2.711 54.932 1.068 1.00 37.42 ? 205 PHE A CB 1 ATOM 1635 C CG . PHE A 1 205 ? -3.520 54.189 2.077 1.00 39.56 ? 205 PHE A CG 1 ATOM 1636 C CD1 . PHE A 1 205 ? -3.223 54.290 3.436 1.00 41.52 ? 205 PHE A CD1 1 ATOM 1637 C CD2 . PHE A 1 205 ? -4.558 53.356 1.675 1.00 40.44 ? 205 PHE A CD2 1 ATOM 1638 C CE1 . PHE A 1 205 ? -3.953 53.564 4.389 1.00 42.38 ? 205 PHE A CE1 1 ATOM 1639 C CE2 . PHE A 1 205 ? -5.296 52.625 2.614 1.00 42.11 ? 205 PHE A CE2 1 ATOM 1640 C CZ . PHE A 1 205 ? -4.990 52.728 3.974 1.00 42.09 ? 205 PHE A CZ 1 ATOM 1641 N N . TYR A 1 206 ? -0.836 52.005 0.722 1.00 34.53 ? 206 TYR A N 1 ATOM 1642 C CA . TYR A 1 206 ? -0.797 50.717 0.037 1.00 33.38 ? 206 TYR A CA 1 ATOM 1643 C C . TYR A 1 206 ? -0.808 49.546 1.008 1.00 33.50 ? 206 TYR A C 1 ATOM 1644 O O . TYR A 1 206 ? -0.536 49.717 2.197 1.00 34.28 ? 206 TYR A O 1 ATOM 1645 C CB . TYR A 1 206 ? 0.467 50.656 -0.807 1.00 33.48 ? 206 TYR A CB 1 ATOM 1646 C CG . TYR A 1 206 ? 1.739 50.900 -0.020 1.00 33.54 ? 206 TYR A CG 1 ATOM 1647 C CD1 . TYR A 1 206 ? 2.400 49.856 0.622 1.00 33.17 ? 206 TYR A CD1 1 ATOM 1648 C CD2 . TYR A 1 206 ? 2.292 52.179 0.066 1.00 33.36 ? 206 TYR A CD2 1 ATOM 1649 C CE1 . TYR A 1 206 ? 3.589 50.080 1.326 1.00 33.23 ? 206 TYR A CE1 1 ATOM 1650 C CE2 . TYR A 1 206 ? 3.474 52.412 0.765 1.00 32.80 ? 206 TYR A CE2 1 ATOM 1651 C CZ . TYR A 1 206 ? 4.119 51.360 1.386 1.00 33.34 ? 206 TYR A CZ 1 ATOM 1652 O OH . TYR A 1 206 ? 5.310 51.593 2.033 1.00 33.26 ? 206 TYR A OH 1 ATOM 1653 N N . PRO A 1 207 ? -1.129 48.339 0.516 1.00 32.70 ? 207 PRO A N 1 ATOM 1654 C CA . PRO A 1 207 ? -1.164 47.145 1.365 1.00 32.32 ? 207 PRO A CA 1 ATOM 1655 C C . PRO A 1 207 ? 0.142 46.345 1.327 1.00 33.25 ? 207 PRO A C 1 ATOM 1656 O O . PRO A 1 207 ? 0.925 46.445 0.378 1.00 34.30 ? 207 PRO A O 1 ATOM 1657 C CB . PRO A 1 207 ? -2.325 46.358 0.777 1.00 31.44 ? 207 PRO A CB 1 ATOM 1658 C CG . PRO A 1 207 ? -2.155 46.598 -0.665 1.00 30.59 ? 207 PRO A CG 1 ATOM 1659 C CD . PRO A 1 207 ? -1.872 48.095 -0.733 1.00 31.60 ? 207 PRO A CD 1 ATOM 1660 N N . VAL A 1 208 ? 0.377 45.553 2.366 1.00 33.70 ? 208 VAL A N 1 ATOM 1661 C CA . VAL A 1 208 ? 1.572 44.720 2.444 1.00 33.88 ? 208 VAL A CA 1 ATOM 1662 C C . VAL A 1 208 ? 1.173 43.352 2.996 1.00 36.11 ? 208 VAL A C 1 ATOM 1663 O O . VAL A 1 208 ? 0.525 43.256 4.041 1.00 36.64 ? 208 VAL A O 1 ATOM 1664 C CB . VAL A 1 208 ? 2.655 45.348 3.365 1.00 31.81 ? 208 VAL A CB 1 ATOM 1665 C CG1 . VAL A 1 208 ? 3.120 46.666 2.796 1.00 29.80 ? 208 VAL A CG1 1 ATOM 1666 C CG2 . VAL A 1 208 ? 2.109 45.543 4.763 1.00 30.39 ? 208 VAL A CG2 1 ATOM 1667 N N . PRO A 1 209 ? 1.549 42.273 2.297 1.00 37.18 ? 209 PRO A N 1 ATOM 1668 C CA . PRO A 1 209 ? 1.213 40.923 2.742 1.00 38.92 ? 209 PRO A CA 1 ATOM 1669 C C . PRO A 1 209 ? 1.933 40.540 4.025 1.00 40.56 ? 209 PRO A C 1 ATOM 1670 O O . PRO A 1 209 ? 3.151 40.696 4.123 1.00 41.54 ? 209 PRO A O 1 ATOM 1671 C CB . PRO A 1 209 ? 1.675 40.071 1.577 1.00 38.13 ? 209 PRO A CB 1 ATOM 1672 C CG . PRO A 1 209 ? 2.917 40.767 1.181 1.00 36.97 ? 209 PRO A CG 1 ATOM 1673 C CD . PRO A 1 209 ? 2.449 42.206 1.136 1.00 37.01 ? 209 PRO A CD 1 ATOM 1674 N N . LEU A 1 210 ? 1.181 40.042 5.003 1.00 42.37 ? 210 LEU A N 1 ATOM 1675 C CA . LEU A 1 210 ? 1.771 39.617 6.266 1.00 43.74 ? 210 LEU A CA 1 ATOM 1676 C C . LEU A 1 210 ? 2.493 38.308 6.026 1.00 46.32 ? 210 LEU A C 1 ATOM 1677 O O . LEU A 1 210 ? 2.085 37.510 5.178 1.00 45.89 ? 210 LEU A O 1 ATOM 1678 C CB . LEU A 1 210 ? 0.699 39.415 7.341 1.00 41.53 ? 210 LEU A CB 1 ATOM 1679 C CG . LEU A 1 210 ? 0.078 40.670 7.960 1.00 40.63 ? 210 LEU A CG 1 ATOM 1680 C CD1 . LEU A 1 210 ? -0.945 40.292 9.011 1.00 39.54 ? 210 LEU A CD1 1 ATOM 1681 C CD2 . LEU A 1 210 ? 1.174 41.504 8.580 1.00 41.06 ? 210 LEU A CD2 1 ATOM 1682 N N . ASN A 1 211 ? 3.564 38.098 6.784 1.00 50.25 ? 211 ASN A N 1 ATOM 1683 C CA . ASN A 1 211 ? 4.386 36.896 6.682 1.00 52.91 ? 211 ASN A CA 1 ATOM 1684 C C . ASN A 1 211 ? 4.737 36.632 5.219 1.00 52.14 ? 211 ASN A C 1 ATOM 1685 O O . ASN A 1 211 ? 4.541 35.530 4.707 1.00 51.79 ? 211 ASN A O 1 ATOM 1686 C CB . ASN A 1 211 ? 3.653 35.688 7.297 1.00 55.79 ? 211 ASN A CB 1 ATOM 1687 C CG . ASN A 1 211 ? 4.557 34.463 7.452 1.00 59.86 ? 211 ASN A CG 1 ATOM 1688 O OD1 . ASN A 1 211 ? 5.652 34.544 8.028 1.00 61.96 ? 211 ASN A OD1 1 ATOM 1689 N ND2 . ASN A 1 211 ? 4.097 33.320 6.944 1.00 60.77 ? 211 ASN A ND2 1 ATOM 1690 N N . SER A 1 212 ? 5.246 37.664 4.551 1.00 51.83 ? 212 SER A N 1 ATOM 1691 C CA . SER A 1 212 ? 5.648 37.563 3.151 1.00 52.15 ? 212 SER A CA 1 ATOM 1692 C C . SER A 1 212 ? 6.571 38.701 2.759 1.00 52.60 ? 212 SER A C 1 ATOM 1693 O O . SER A 1 212 ? 6.464 39.812 3.282 1.00 54.50 ? 212 SER A O 1 ATOM 1694 C CB . SER A 1 212 ? 4.441 37.590 2.220 1.00 50.99 ? 212 SER A CB 1 ATOM 1695 O OG . SER A 1 212 ? 4.889 37.548 0.875 1.00 49.44 ? 212 SER A OG 1 ATOM 1696 N N . THR A 1 213 ? 7.469 38.429 1.821 1.00 51.54 ? 213 THR A N 1 ATOM 1697 C CA . THR A 1 213 ? 8.396 39.454 1.372 1.00 50.46 ? 213 THR A CA 1 ATOM 1698 C C . THR A 1 213 ? 8.041 39.914 -0.028 1.00 49.75 ? 213 THR A C 1 ATOM 1699 O O . THR A 1 213 ? 8.879 40.472 -0.733 1.00 50.41 ? 213 THR A O 1 ATOM 1700 C CB . THR A 1 213 ? 9.836 38.939 1.366 1.00 49.71 ? 213 THR A CB 1 ATOM 1701 O OG1 . THR A 1 213 ? 9.973 37.902 0.385 1.00 49.53 ? 213 THR A OG1 1 ATOM 1702 C CG2 . THR A 1 213 ? 10.190 38.395 2.726 1.00 48.66 ? 213 THR A CG2 1 ATOM 1703 N N . ASN A 1 214 ? 6.802 39.670 -0.436 1.00 48.68 ? 214 ASN A N 1 ATOM 1704 C CA . ASN A 1 214 ? 6.372 40.083 -1.761 1.00 49.22 ? 214 ASN A CA 1 ATOM 1705 C C . ASN A 1 214 ? 5.506 41.317 -1.670 1.00 48.43 ? 214 ASN A C 1 ATOM 1706 O O . ASN A 1 214 ? 5.119 41.732 -0.583 1.00 48.74 ? 214 ASN A O 1 ATOM 1707 C CB . ASN A 1 214 ? 5.592 38.970 -2.460 1.00 50.57 ? 214 ASN A CB 1 ATOM 1708 C CG . ASN A 1 214 ? 6.425 37.734 -2.685 1.00 52.49 ? 214 ASN A CG 1 ATOM 1709 O OD1 . ASN A 1 214 ? 7.579 37.814 -3.115 1.00 53.43 ? 214 ASN A OD1 1 ATOM 1710 N ND2 . ASN A 1 214 ? 5.846 36.575 -2.401 1.00 54.31 ? 214 ASN A ND2 1 ATOM 1711 N N . GLY A 1 215 ? 5.208 41.908 -2.819 1.00 47.51 ? 215 GLY A N 1 ATOM 1712 C CA . GLY A 1 215 ? 4.381 43.093 -2.829 1.00 46.76 ? 215 GLY A CA 1 ATOM 1713 C C . GLY A 1 215 ? 2.952 42.722 -3.148 1.00 46.64 ? 215 GLY A C 1 ATOM 1714 O O . GLY A 1 215 ? 2.660 41.572 -3.466 1.00 46.57 ? 215 GLY A O 1 ATOM 1715 N N . LEU A 1 216 ? 2.059 43.697 -3.047 1.00 46.57 ? 216 LEU A N 1 ATOM 1716 C CA . LEU A 1 216 ? 0.650 43.490 -3.346 1.00 45.94 ? 216 LEU A CA 1 ATOM 1717 C C . LEU A 1 216 ? 0.171 44.668 -4.172 1.00 46.74 ? 216 LEU A C 1 ATOM 1718 O O . LEU A 1 216 ? 0.646 45.788 -3.997 1.00 46.76 ? 216 LEU A O 1 ATOM 1719 C CB . LEU A 1 216 ? -0.192 43.427 -2.063 1.00 43.57 ? 216 LEU A CB 1 ATOM 1720 C CG . LEU A 1 216 ? -0.116 42.228 -1.122 1.00 41.25 ? 216 LEU A CG 1 ATOM 1721 C CD1 . LEU A 1 216 ? -1.059 42.441 0.047 1.00 40.34 ? 216 LEU A CD1 1 ATOM 1722 C CD2 . LEU A 1 216 ? -0.488 40.980 -1.869 1.00 39.30 ? 216 LEU A CD2 1 ATOM 1723 N N . ASP A 1 217 ? -0.760 44.421 -5.082 1.00 48.13 ? 217 ASP A N 1 ATOM 1724 C CA . ASP A 1 217 ? -1.302 45.512 -5.866 1.00 48.94 ? 217 ASP A CA 1 ATOM 1725 C C . ASP A 1 217 ? -2.026 46.408 -4.848 1.00 48.45 ? 217 ASP A C 1 ATOM 1726 O O . ASP A 1 217 ? -2.509 45.924 -3.820 1.00 47.19 ? 217 ASP A O 1 ATOM 1727 C CB . ASP A 1 217 ? -2.290 44.983 -6.899 1.00 51.85 ? 217 ASP A CB 1 ATOM 1728 C CG . ASP A 1 217 ? -2.891 46.087 -7.735 1.00 56.27 ? 217 ASP A CG 1 ATOM 1729 O OD1 . ASP A 1 217 ? -2.161 46.647 -8.585 1.00 59.99 ? 217 ASP A OD1 1 ATOM 1730 O OD2 . ASP A 1 217 ? -4.087 46.408 -7.533 1.00 58.02 ? 217 ASP A OD2 1 ATOM 1731 N N . THR A 1 218 ? -2.102 47.704 -5.133 1.00 47.20 ? 218 THR A N 1 ATOM 1732 C CA . THR A 1 218 ? -2.744 48.658 -4.237 1.00 45.81 ? 218 THR A CA 1 ATOM 1733 C C . THR A 1 218 ? -4.146 48.266 -3.777 1.00 46.41 ? 218 THR A C 1 ATOM 1734 O O . THR A 1 218 ? -4.583 48.657 -2.687 1.00 47.74 ? 218 THR A O 1 ATOM 1735 C CB . THR A 1 218 ? -2.861 50.030 -4.899 1.00 44.68 ? 218 THR A CB 1 ATOM 1736 O OG1 . THR A 1 218 ? -1.683 50.289 -5.664 1.00 45.41 ? 218 THR A OG1 1 ATOM 1737 C CG2 . THR A 1 218 ? -3.018 51.113 -3.845 1.00 43.22 ? 218 THR A CG2 1 ATOM 1738 N N . SER A 1 219 ? -4.850 47.491 -4.593 1.00 45.63 ? 219 SER A N 1 ATOM 1739 C CA . SER A 1 219 ? -6.214 47.118 -4.257 1.00 45.20 ? 219 SER A CA 1 ATOM 1740 C C . SER A 1 219 ? -6.434 45.781 -3.562 1.00 46.01 ? 219 SER A C 1 ATOM 1741 O O . SER A 1 219 ? -7.363 45.052 -3.894 1.00 47.10 ? 219 SER A O 1 ATOM 1742 C CB . SER A 1 219 ? -7.078 47.189 -5.513 1.00 43.15 ? 219 SER A CB 1 ATOM 1743 O OG . SER A 1 219 ? -7.097 48.505 -6.026 1.00 40.40 ? 219 SER A OG 1 ATOM 1744 N N . VAL A 1 220 ? -5.604 45.456 -2.583 1.00 46.47 ? 220 VAL A N 1 ATOM 1745 C CA . VAL A 1 220 ? -5.783 44.200 -1.867 1.00 46.78 ? 220 VAL A CA 1 ATOM 1746 C C . VAL A 1 220 ? -6.212 44.493 -0.442 1.00 49.17 ? 220 VAL A C 1 ATOM 1747 O O . VAL A 1 220 ? -5.671 45.394 0.199 1.00 50.12 ? 220 VAL A O 1 ATOM 1748 C CB . VAL A 1 220 ? -4.493 43.391 -1.833 1.00 44.94 ? 220 VAL A CB 1 ATOM 1749 C CG1 . VAL A 1 220 ? -4.712 42.112 -1.066 1.00 42.95 ? 220 VAL A CG1 1 ATOM 1750 C CG2 . VAL A 1 220 ? -4.036 43.112 -3.239 1.00 43.22 ? 220 VAL A CG2 1 ATOM 1751 N N . TYR A 1 221 ? -7.194 43.744 0.046 1.00 51.21 ? 221 TYR A N 1 ATOM 1752 C CA . TYR A 1 221 ? -7.689 43.924 1.404 1.00 53.40 ? 221 TYR A CA 1 ATOM 1753 C C . TYR A 1 221 ? -7.767 42.552 2.028 1.00 54.87 ? 221 TYR A C 1 ATOM 1754 O O . TYR A 1 221 ? -7.983 41.567 1.327 1.00 56.65 ? 221 TYR A O 1 ATOM 1755 C CB . TYR A 1 221 ? -9.075 44.568 1.395 1.00 53.38 ? 221 TYR A CB 1 ATOM 1756 C CG . TYR A 1 221 ? -9.177 45.703 0.416 1.00 55.08 ? 221 TYR A CG 1 ATOM 1757 C CD1 . TYR A 1 221 ? -9.568 45.472 -0.899 1.00 55.86 ? 221 TYR A CD1 1 ATOM 1758 C CD2 . TYR A 1 221 ? -8.792 46.992 0.772 1.00 56.01 ? 221 TYR A CD2 1 ATOM 1759 C CE1 . TYR A 1 221 ? -9.567 46.489 -1.840 1.00 57.16 ? 221 TYR A CE1 1 ATOM 1760 C CE2 . TYR A 1 221 ? -8.782 48.023 -0.162 1.00 57.45 ? 221 TYR A CE2 1 ATOM 1761 C CZ . TYR A 1 221 ? -9.169 47.759 -1.468 1.00 58.54 ? 221 TYR A CZ 1 ATOM 1762 O OH . TYR A 1 221 ? -9.127 48.752 -2.420 1.00 60.35 ? 221 TYR A OH 1 ATOM 1763 N N . GLY A 1 222 ? -7.583 42.474 3.338 1.00 56.04 ? 222 GLY A N 1 ATOM 1764 C CA . GLY A 1 222 ? -7.640 41.177 3.982 1.00 57.27 ? 222 GLY A CA 1 ATOM 1765 C C . GLY A 1 222 ? -7.123 41.171 5.399 1.00 58.40 ? 222 GLY A C 1 ATOM 1766 O O . GLY A 1 222 ? -6.758 42.213 5.953 1.00 59.54 ? 222 GLY A O 1 ATOM 1767 N N . GLY A 1 223 ? -7.097 39.986 5.992 1.00 58.03 ? 223 GLY A N 1 ATOM 1768 C CA . GLY A 1 223 ? -6.620 39.868 7.355 1.00 58.40 ? 223 GLY A CA 1 ATOM 1769 C C . GLY A 1 223 ? -5.136 39.594 7.346 1.00 58.29 ? 223 GLY A C 1 ATOM 1770 O O . GLY A 1 223 ? -4.437 39.844 8.334 1.00 58.85 ? 223 GLY A O 1 ATOM 1771 N N . SER A 1 224 ? -4.662 39.075 6.218 1.00 56.99 ? 224 SER A N 1 ATOM 1772 C CA . SER A 1 224 ? -3.254 38.754 6.044 1.00 56.41 ? 224 SER A CA 1 ATOM 1773 C C . SER A 1 224 ? -2.598 39.947 5.383 1.00 54.79 ? 224 SER A C 1 ATOM 1774 O O . SER A 1 224 ? -1.522 39.843 4.793 1.00 54.24 ? 224 SER A O 1 ATOM 1775 C CB . SER A 1 224 ? -3.116 37.535 5.150 1.00 57.50 ? 224 SER A CB 1 ATOM 1776 O OG . SER A 1 224 ? -3.828 37.756 3.949 1.00 60.80 ? 224 SER A OG 1 ATOM 1777 N N . VAL A 1 225 ? -3.277 41.081 5.487 1.00 53.24 ? 225 VAL A N 1 ATOM 1778 C CA . VAL A 1 225 ? -2.810 42.321 4.904 1.00 51.54 ? 225 VAL A CA 1 ATOM 1779 C C . VAL A 1 225 ? -2.901 43.467 5.892 1.00 50.48 ? 225 VAL A C 1 ATOM 1780 O O . VAL A 1 225 ? -3.855 43.573 6.664 1.00 51.53 ? 225 VAL A O 1 ATOM 1781 C CB . VAL A 1 225 ? -3.654 42.703 3.685 1.00 51.32 ? 225 VAL A CB 1 ATOM 1782 C CG1 . VAL A 1 225 ? -3.038 43.883 2.985 1.00 51.74 ? 225 VAL A CG1 1 ATOM 1783 C CG2 . VAL A 1 225 ? -3.770 41.531 2.752 1.00 53.14 ? 225 VAL A CG2 1 ATOM 1784 N N . ARG A 1 226 ? -1.894 44.323 5.855 1.00 48.68 ? 226 ARG A N 1 ATOM 1785 C CA . ARG A 1 226 ? -1.845 45.501 6.700 1.00 47.23 ? 226 ARG A CA 1 ATOM 1786 C C . ARG A 1 226 ? -1.665 46.673 5.747 1.00 46.62 ? 226 ARG A C 1 ATOM 1787 O O . ARG A 1 226 ? -1.173 46.491 4.631 1.00 47.26 ? 226 ARG A O 1 ATOM 1788 C CB . ARG A 1 226 ? -0.667 45.410 7.670 1.00 46.89 ? 226 ARG A CB 1 ATOM 1789 C CG . ARG A 1 226 ? -0.940 44.519 8.860 1.00 47.80 ? 226 ARG A CG 1 ATOM 1790 C CD . ARG A 1 226 ? -2.085 45.096 9.683 1.00 50.35 ? 226 ARG A CD 1 ATOM 1791 N NE . ARG A 1 226 ? -2.525 44.214 10.760 1.00 52.18 ? 226 ARG A NE 1 ATOM 1792 C CZ . ARG A 1 226 ? -3.029 42.996 10.572 1.00 54.60 ? 226 ARG A CZ 1 ATOM 1793 N NH1 . ARG A 1 226 ? -3.158 42.503 9.345 1.00 54.86 ? 226 ARG A NH1 1 ATOM 1794 N NH2 . ARG A 1 226 ? -3.412 42.268 11.612 1.00 56.30 ? 226 ARG A NH2 1 ATOM 1795 N N . HIS A 1 227 ? -2.081 47.867 6.147 1.00 44.86 ? 227 HIS A N 1 ATOM 1796 C CA . HIS A 1 227 ? -1.907 49.010 5.262 1.00 43.99 ? 227 HIS A CA 1 ATOM 1797 C C . HIS A 1 227 ? -0.894 50.010 5.780 1.00 42.22 ? 227 HIS A C 1 ATOM 1798 O O . HIS A 1 227 ? -0.731 50.175 6.988 1.00 42.94 ? 227 HIS A O 1 ATOM 1799 C CB . HIS A 1 227 ? -3.241 49.710 4.995 1.00 45.67 ? 227 HIS A CB 1 ATOM 1800 C CG . HIS A 1 227 ? -4.027 49.092 3.882 1.00 47.76 ? 227 HIS A CG 1 ATOM 1801 N ND1 . HIS A 1 227 ? -4.665 47.877 4.010 1.00 48.25 ? 227 HIS A ND1 1 ATOM 1802 C CD2 . HIS A 1 227 ? -4.224 49.489 2.602 1.00 48.24 ? 227 HIS A CD2 1 ATOM 1803 C CE1 . HIS A 1 227 ? -5.218 47.551 2.855 1.00 49.46 ? 227 HIS A CE1 1 ATOM 1804 N NE2 . HIS A 1 227 ? -4.964 48.512 1.983 1.00 49.24 ? 227 HIS A NE2 1 ATOM 1805 N N . VAL A 1 228 ? -0.210 50.672 4.855 1.00 39.53 ? 228 VAL A N 1 ATOM 1806 C CA . VAL A 1 228 ? 0.789 51.655 5.222 1.00 37.29 ? 228 VAL A CA 1 ATOM 1807 C C . VAL A 1 228 ? 0.374 53.055 4.803 1.00 38.39 ? 228 VAL A C 1 ATOM 1808 O O . VAL A 1 228 ? 0.150 53.322 3.623 1.00 39.71 ? 228 VAL A O 1 ATOM 1809 C CB . VAL A 1 228 ? 2.134 51.342 4.568 1.00 34.69 ? 228 VAL A CB 1 ATOM 1810 C CG1 . VAL A 1 228 ? 3.153 52.380 4.974 1.00 32.87 ? 228 VAL A CG1 1 ATOM 1811 C CG2 . VAL A 1 228 ? 2.591 49.956 4.966 1.00 33.99 ? 228 VAL A CG2 1 ATOM 1812 N N . MET A 1 229 ? 0.260 53.948 5.778 1.00 38.67 ? 229 MET A N 1 ATOM 1813 C CA . MET A 1 229 ? -0.099 55.336 5.513 1.00 38.38 ? 229 MET A CA 1 ATOM 1814 C C . MET A 1 229 ? 1.196 56.139 5.595 1.00 37.51 ? 229 MET A C 1 ATOM 1815 O O . MET A 1 229 ? 1.686 56.423 6.688 1.00 38.22 ? 229 MET A O 1 ATOM 1816 C CB . MET A 1 229 ? -1.089 55.830 6.570 1.00 40.27 ? 229 MET A CB 1 ATOM 1817 C CG . MET A 1 229 ? -1.453 57.307 6.473 1.00 42.78 ? 229 MET A CG 1 ATOM 1818 S SD . MET A 1 229 ? -2.451 57.732 5.030 1.00 47.08 ? 229 MET A SD 1 ATOM 1819 C CE . MET A 1 229 ? -1.162 58.251 3.896 1.00 46.27 ? 229 MET A CE 1 ATOM 1820 N N . LYS A 1 230 ? 1.762 56.481 4.443 1.00 35.25 ? 230 LYS A N 1 ATOM 1821 C CA . LYS A 1 230 ? 3.004 57.239 4.413 1.00 34.64 ? 230 LYS A CA 1 ATOM 1822 C C . LYS A 1 230 ? 2.732 58.674 4.032 1.00 35.20 ? 230 LYS A C 1 ATOM 1823 O O . LYS A 1 230 ? 1.863 58.951 3.220 1.00 37.61 ? 230 LYS A O 1 ATOM 1824 C CB . LYS A 1 230 ? 3.989 56.622 3.417 1.00 33.36 ? 230 LYS A CB 1 ATOM 1825 C CG . LYS A 1 230 ? 5.281 57.408 3.232 1.00 32.45 ? 230 LYS A CG 1 ATOM 1826 C CD . LYS A 1 230 ? 5.145 58.467 2.158 1.00 32.66 ? 230 LYS A CD 1 ATOM 1827 C CE . LYS A 1 230 ? 6.425 59.274 2.008 1.00 33.60 ? 230 LYS A CE 1 ATOM 1828 N NZ . LYS A 1 230 ? 6.368 60.288 0.897 1.00 34.22 ? 230 LYS A NZ 1 ATOM 1829 N N . ALA A 1 231 ? 3.480 59.594 4.616 1.00 35.23 ? 231 ALA A N 1 ATOM 1830 C CA . ALA A 1 231 ? 3.295 60.997 4.310 1.00 35.61 ? 231 ALA A CA 1 ATOM 1831 C C . ALA A 1 231 ? 4.579 61.735 4.618 1.00 37.39 ? 231 ALA A C 1 ATOM 1832 O O . ALA A 1 231 ? 5.345 61.349 5.510 1.00 37.85 ? 231 ALA A O 1 ATOM 1833 C CB . ALA A 1 231 ? 2.153 61.565 5.130 1.00 33.83 ? 231 ALA A CB 1 ATOM 1834 N N . GLY A 1 232 ? 4.823 62.800 3.873 1.00 37.89 ? 232 GLY A N 1 ATOM 1835 C CA . GLY A 1 232 ? 6.021 63.568 4.115 1.00 39.41 ? 232 GLY A CA 1 ATOM 1836 C C . GLY A 1 232 ? 5.666 64.885 4.757 1.00 39.63 ? 232 GLY A C 1 ATOM 1837 O O . GLY A 1 232 ? 4.838 65.616 4.232 1.00 40.68 ? 232 GLY A O 1 ATOM 1838 N N . PHE A 1 233 ? 6.267 65.179 5.903 1.00 40.64 ? 233 PHE A N 1 ATOM 1839 C CA . PHE A 1 233 ? 6.021 66.445 6.581 1.00 41.73 ? 233 PHE A CA 1 ATOM 1840 C C . PHE A 1 233 ? 7.142 66.775 7.547 1.00 42.51 ? 233 PHE A C 1 ATOM 1841 O O . PHE A 1 233 ? 7.775 65.887 8.110 1.00 43.09 ? 233 PHE A O 1 ATOM 1842 C CB . PHE A 1 233 ? 4.658 66.447 7.295 1.00 41.09 ? 233 PHE A CB 1 ATOM 1843 C CG . PHE A 1 233 ? 4.469 65.335 8.292 1.00 39.95 ? 233 PHE A CG 1 ATOM 1844 C CD1 . PHE A 1 233 ? 5.025 65.418 9.561 1.00 37.63 ? 233 PHE A CD1 1 ATOM 1845 C CD2 . PHE A 1 233 ? 3.706 64.211 7.964 1.00 40.42 ? 233 PHE A CD2 1 ATOM 1846 C CE1 . PHE A 1 233 ? 4.820 64.402 10.495 1.00 38.82 ? 233 PHE A CE1 1 ATOM 1847 C CE2 . PHE A 1 233 ? 3.493 63.185 8.893 1.00 39.50 ? 233 PHE A CE2 1 ATOM 1848 C CZ . PHE A 1 233 ? 4.053 63.282 10.157 1.00 38.46 ? 233 PHE A CZ 1 ATOM 1849 N N . GLU A 1 234 ? 7.385 68.065 7.721 1.00 43.76 ? 234 GLU A N 1 ATOM 1850 C CA . GLU A 1 234 ? 8.445 68.546 8.595 1.00 44.37 ? 234 GLU A CA 1 ATOM 1851 C C . GLU A 1 234 ? 9.808 68.047 8.115 1.00 42.96 ? 234 GLU A C 1 ATOM 1852 O O . GLU A 1 234 ? 10.711 67.789 8.916 1.00 42.67 ? 234 GLU A O 1 ATOM 1853 C CB . GLU A 1 234 ? 8.182 68.135 10.052 1.00 45.78 ? 234 GLU A CB 1 ATOM 1854 C CG . GLU A 1 234 ? 6.876 68.712 10.614 1.00 49.43 ? 234 GLU A CG 1 ATOM 1855 C CD . GLU A 1 234 ? 6.690 68.471 12.106 1.00 51.55 ? 234 GLU A CD 1 ATOM 1856 O OE1 . GLU A 1 234 ? 7.031 67.365 12.588 1.00 54.28 ? 234 GLU A OE1 1 ATOM 1857 O OE2 . GLU A 1 234 ? 6.187 69.382 12.801 1.00 51.41 ? 234 GLU A OE2 1 ATOM 1858 N N . GLY A 1 235 ? 9.938 67.902 6.798 1.00 40.80 ? 235 GLY A N 1 ATOM 1859 C CA . GLY A 1 235 ? 11.199 67.486 6.213 1.00 41.46 ? 235 GLY A CA 1 ATOM 1860 C C . GLY A 1 235 ? 11.527 66.008 6.080 1.00 42.31 ? 235 GLY A C 1 ATOM 1861 O O . GLY A 1 235 ? 12.608 65.652 5.606 1.00 42.92 ? 235 GLY A O 1 ATOM 1862 N N . HIS A 1 236 ? 10.629 65.126 6.485 1.00 41.87 ? 236 HIS A N 1 ATOM 1863 C CA . HIS A 1 236 ? 10.948 63.720 6.360 1.00 42.14 ? 236 HIS A CA 1 ATOM 1864 C C . HIS A 1 236 ? 9.767 62.927 5.880 1.00 41.75 ? 236 HIS A C 1 ATOM 1865 O O . HIS A 1 236 ? 8.653 63.443 5.799 1.00 41.93 ? 236 HIS A O 1 ATOM 1866 C CB . HIS A 1 236 ? 11.420 63.161 7.699 1.00 44.00 ? 236 HIS A CB 1 ATOM 1867 C CG . HIS A 1 236 ? 12.630 63.849 8.245 1.00 46.06 ? 236 HIS A CG 1 ATOM 1868 N ND1 . HIS A 1 236 ? 12.586 64.658 9.360 1.00 47.58 ? 236 HIS A ND1 1 ATOM 1869 C CD2 . HIS A 1 236 ? 13.917 63.857 7.824 1.00 46.44 ? 236 HIS A CD2 1 ATOM 1870 C CE1 . HIS A 1 236 ? 13.794 65.132 9.605 1.00 48.02 ? 236 HIS A CE1 1 ATOM 1871 N NE2 . HIS A 1 236 ? 14.620 64.661 8.687 1.00 48.18 ? 236 HIS A NE2 1 ATOM 1872 N N . ASP A 1 237 ? 10.020 61.671 5.539 1.00 40.03 ? 237 ASP A N 1 ATOM 1873 C CA . ASP A 1 237 ? 8.948 60.803 5.112 1.00 39.47 ? 237 ASP A CA 1 ATOM 1874 C C . ASP A 1 237 ? 8.640 59.839 6.255 1.00 39.60 ? 237 ASP A C 1 ATOM 1875 O O . ASP A 1 237 ? 9.457 58.982 6.604 1.00 39.36 ? 237 ASP A O 1 ATOM 1876 C CB . ASP A 1 237 ? 9.337 60.052 3.842 1.00 39.67 ? 237 ASP A CB 1 ATOM 1877 C CG . ASP A 1 237 ? 9.363 60.955 2.619 1.00 41.55 ? 237 ASP A CG 1 ATOM 1878 O OD1 . ASP A 1 237 ? 8.690 62.011 2.620 1.00 41.88 ? 237 ASP A OD1 1 ATOM 1879 O OD2 . ASP A 1 237 ? 10.045 60.600 1.641 1.00 42.74 ? 237 ASP A OD2 1 ATOM 1880 N N . TRP A 1 238 ? 7.458 60.003 6.845 1.00 38.89 ? 238 TRP A N 1 ATOM 1881 C CA . TRP A 1 238 ? 7.024 59.169 7.959 1.00 38.48 ? 238 TRP A CA 1 ATOM 1882 C C . TRP A 1 238 ? 6.012 58.146 7.489 1.00 38.37 ? 238 TRP A C 1 ATOM 1883 O O . TRP A 1 238 ? 5.414 58.317 6.429 1.00 38.74 ? 238 TRP A O 1 ATOM 1884 C CB . TRP A 1 238 ? 6.371 60.041 9.032 1.00 39.47 ? 238 TRP A CB 1 ATOM 1885 C CG . TRP A 1 238 ? 7.171 61.253 9.382 1.00 40.09 ? 238 TRP A CG 1 ATOM 1886 C CD1 . TRP A 1 238 ? 7.138 62.464 8.762 1.00 39.46 ? 238 TRP A CD1 1 ATOM 1887 C CD2 . TRP A 1 238 ? 8.181 61.342 10.392 1.00 40.25 ? 238 TRP A CD2 1 ATOM 1888 N NE1 . TRP A 1 238 ? 8.068 63.307 9.323 1.00 40.40 ? 238 TRP A NE1 1 ATOM 1889 C CE2 . TRP A 1 238 ? 8.723 62.642 10.328 1.00 39.70 ? 238 TRP A CE2 1 ATOM 1890 C CE3 . TRP A 1 238 ? 8.684 60.445 11.348 1.00 40.24 ? 238 TRP A CE3 1 ATOM 1891 C CZ2 . TRP A 1 238 ? 9.743 63.071 11.175 1.00 39.73 ? 238 TRP A CZ2 1 ATOM 1892 C CZ3 . TRP A 1 238 ? 9.697 60.868 12.192 1.00 41.66 ? 238 TRP A CZ3 1 ATOM 1893 C CH2 . TRP A 1 238 ? 10.216 62.173 12.099 1.00 41.77 ? 238 TRP A CH2 1 ATOM 1894 N N . TYR A 1 239 ? 5.817 57.083 8.266 1.00 37.87 ? 239 TYR A N 1 ATOM 1895 C CA . TYR A 1 239 ? 4.817 56.083 7.906 1.00 38.37 ? 239 TYR A CA 1 ATOM 1896 C C . TYR A 1 239 ? 4.307 55.342 9.132 1.00 39.65 ? 239 TYR A C 1 ATOM 1897 O O . TYR A 1 239 ? 4.920 55.383 10.197 1.00 39.53 ? 239 TYR A O 1 ATOM 1898 C CB . TYR A 1 239 ? 5.365 55.096 6.865 1.00 36.54 ? 239 TYR A CB 1 ATOM 1899 C CG . TYR A 1 239 ? 6.239 53.989 7.399 1.00 35.95 ? 239 TYR A CG 1 ATOM 1900 C CD1 . TYR A 1 239 ? 5.685 52.883 8.037 1.00 35.62 ? 239 TYR A CD1 1 ATOM 1901 C CD2 . TYR A 1 239 ? 7.622 54.029 7.239 1.00 35.90 ? 239 TYR A CD2 1 ATOM 1902 C CE1 . TYR A 1 239 ? 6.488 51.845 8.500 1.00 35.62 ? 239 TYR A CE1 1 ATOM 1903 C CE2 . TYR A 1 239 ? 8.432 52.999 7.698 1.00 34.87 ? 239 TYR A CE2 1 ATOM 1904 C CZ . TYR A 1 239 ? 7.858 51.914 8.324 1.00 35.57 ? 239 TYR A CZ 1 ATOM 1905 O OH . TYR A 1 239 ? 8.658 50.896 8.769 1.00 36.27 ? 239 TYR A OH 1 ATOM 1906 N N . THR A 1 240 ? 3.168 54.677 8.976 1.00 41.37 ? 240 THR A N 1 ATOM 1907 C CA . THR A 1 240 ? 2.562 53.919 10.064 1.00 41.26 ? 240 THR A CA 1 ATOM 1908 C C . THR A 1 240 ? 1.741 52.753 9.520 1.00 41.78 ? 240 THR A C 1 ATOM 1909 O O . THR A 1 240 ? 0.854 52.936 8.683 1.00 42.07 ? 240 THR A O 1 ATOM 1910 C CB . THR A 1 240 ? 1.648 54.814 10.915 1.00 41.04 ? 240 THR A CB 1 ATOM 1911 O OG1 . THR A 1 240 ? 0.834 53.996 11.767 1.00 41.15 ? 240 THR A OG1 1 ATOM 1912 C CG2 . THR A 1 240 ? 0.767 55.672 10.016 1.00 40.03 ? 240 THR A CG2 1 ATOM 1913 N N . ILE A 1 241 ? 2.051 51.554 9.998 1.00 41.42 ? 241 ILE A N 1 ATOM 1914 C CA . ILE A 1 241 ? 1.354 50.340 9.587 1.00 40.34 ? 241 ILE A CA 1 ATOM 1915 C C . ILE A 1 241 ? 0.042 50.193 10.363 1.00 41.20 ? 241 ILE A C 1 ATOM 1916 O O . ILE A 1 241 ? 0.024 50.305 11.590 1.00 42.40 ? 241 ILE A O 1 ATOM 1917 C CB . ILE A 1 241 ? 2.222 49.121 9.872 1.00 38.38 ? 241 ILE A CB 1 ATOM 1918 C CG1 . ILE A 1 241 ? 3.565 49.272 9.161 1.00 37.08 ? 241 ILE A CG1 1 ATOM 1919 C CG2 . ILE A 1 241 ? 1.490 47.866 9.466 1.00 38.76 ? 241 ILE A CG2 1 ATOM 1920 C CD1 . ILE A 1 241 ? 4.574 48.201 9.538 1.00 37.62 ? 241 ILE A CD1 1 ATOM 1921 N N . GLY A 1 242 ? -1.051 49.934 9.658 1.00 41.23 ? 242 GLY A N 1 ATOM 1922 C CA . GLY A 1 242 ? -2.320 49.794 10.342 1.00 42.07 ? 242 GLY A CA 1 ATOM 1923 C C . GLY A 1 242 ? -3.327 48.956 9.586 1.00 43.33 ? 242 GLY A C 1 ATOM 1924 O O . GLY A 1 242 ? -2.992 48.284 8.612 1.00 43.86 ? 242 GLY A O 1 ATOM 1925 N N . THR A 1 243 ? -4.573 49.006 10.038 1.00 44.53 ? 243 THR A N 1 ATOM 1926 C CA . THR A 1 243 ? -5.652 48.249 9.422 1.00 44.92 ? 243 THR A CA 1 ATOM 1927 C C . THR A 1 243 ? -6.603 49.170 8.682 1.00 45.83 ? 243 THR A C 1 ATOM 1928 O O . THR A 1 243 ? -7.037 50.188 9.227 1.00 45.71 ? 243 THR A O 1 ATOM 1929 C CB . THR A 1 243 ? -6.432 47.481 10.482 1.00 44.85 ? 243 THR A CB 1 ATOM 1930 O OG1 . THR A 1 243 ? -5.614 46.418 10.986 1.00 44.89 ? 243 THR A OG1 1 ATOM 1931 C CG2 . THR A 1 243 ? -7.707 46.918 9.899 1.00 45.54 ? 243 THR A CG2 1 ATOM 1932 N N . TYR A 1 244 ? -6.931 48.795 7.446 1.00 46.61 ? 244 TYR A N 1 ATOM 1933 C CA . TYR A 1 244 ? -7.822 49.584 6.602 1.00 47.41 ? 244 TYR A CA 1 ATOM 1934 C C . TYR A 1 244 ? -9.125 48.879 6.265 1.00 48.24 ? 244 TYR A C 1 ATOM 1935 O O . TYR A 1 244 ? -9.123 47.733 5.839 1.00 48.28 ? 244 TYR A O 1 ATOM 1936 C CB . TYR A 1 244 ? -7.110 49.954 5.297 1.00 46.75 ? 244 TYR A CB 1 ATOM 1937 C CG . TYR A 1 244 ? -7.984 50.661 4.287 1.00 45.07 ? 244 TYR A CG 1 ATOM 1938 C CD1 . TYR A 1 244 ? -8.653 51.836 4.618 1.00 44.61 ? 244 TYR A CD1 1 ATOM 1939 C CD2 . TYR A 1 244 ? -8.121 50.166 2.991 1.00 43.90 ? 244 TYR A CD2 1 ATOM 1940 C CE1 . TYR A 1 244 ? -9.436 52.504 3.684 1.00 44.39 ? 244 TYR A CE1 1 ATOM 1941 C CE2 . TYR A 1 244 ? -8.899 50.825 2.046 1.00 44.07 ? 244 TYR A CE2 1 ATOM 1942 C CZ . TYR A 1 244 ? -9.554 51.992 2.399 1.00 44.72 ? 244 TYR A CZ 1 ATOM 1943 O OH . TYR A 1 244 ? -10.336 52.651 1.479 1.00 43.87 ? 244 TYR A OH 1 ATOM 1944 N N . SER A 1 245 ? -10.231 49.587 6.458 1.00 50.52 ? 245 SER A N 1 ATOM 1945 C CA . SER A 1 245 ? -11.562 49.077 6.156 1.00 52.84 ? 245 SER A CA 1 ATOM 1946 C C . SER A 1 245 ? -12.136 49.980 5.072 1.00 54.07 ? 245 SER A C 1 ATOM 1947 O O . SER A 1 245 ? -12.624 51.073 5.366 1.00 54.61 ? 245 SER A O 1 ATOM 1948 C CB . SER A 1 245 ? -12.455 49.150 7.394 1.00 53.34 ? 245 SER A CB 1 ATOM 1949 O OG . SER A 1 245 ? -13.812 48.955 7.040 1.00 53.77 ? 245 SER A OG 1 ATOM 1950 N N . PRO A 1 246 ? -12.084 49.542 3.805 1.00 54.55 ? 246 PRO A N 1 ATOM 1951 C CA . PRO A 1 246 ? -12.615 50.370 2.721 1.00 56.03 ? 246 PRO A CA 1 ATOM 1952 C C . PRO A 1 246 ? -14.090 50.728 2.897 1.00 57.76 ? 246 PRO A C 1 ATOM 1953 O O . PRO A 1 246 ? -14.519 51.831 2.546 1.00 57.15 ? 246 PRO A O 1 ATOM 1954 C CB . PRO A 1 246 ? -12.337 49.522 1.478 1.00 55.02 ? 246 PRO A CB 1 ATOM 1955 C CG . PRO A 1 246 ? -12.383 48.131 1.998 1.00 54.20 ? 246 PRO A CG 1 ATOM 1956 C CD . PRO A 1 246 ? -11.643 48.234 3.298 1.00 54.34 ? 246 PRO A CD 1 ATOM 1957 N N . ASP A 1 247 ? -14.852 49.792 3.458 1.00 60.31 ? 247 ASP A N 1 ATOM 1958 C CA . ASP A 1 247 ? -16.282 49.970 3.704 1.00 62.35 ? 247 ASP A CA 1 ATOM 1959 C C . ASP A 1 247 ? -16.536 51.048 4.755 1.00 62.18 ? 247 ASP A C 1 ATOM 1960 O O . ASP A 1 247 ? -17.099 52.096 4.448 1.00 61.58 ? 247 ASP A O 1 ATOM 1961 C CB . ASP A 1 247 ? -16.897 48.640 4.146 1.00 65.96 ? 247 ASP A CB 1 ATOM 1962 C CG . ASP A 1 247 ? -15.857 47.675 4.715 1.00 71.29 ? 247 ASP A CG 1 ATOM 1963 O OD1 . ASP A 1 247 ? -15.040 47.132 3.930 1.00 72.90 ? 247 ASP A OD1 1 ATOM 1964 O OD2 . ASP A 1 247 ? -15.847 47.461 5.951 1.00 74.02 ? 247 ASP A OD2 1 ATOM 1965 N N . ARG A 1 248 ? -16.124 50.790 5.995 1.00 62.85 ? 248 ARG A N 1 ATOM 1966 C CA . ARG A 1 248 ? -16.298 51.762 7.075 1.00 62.88 ? 248 ARG A CA 1 ATOM 1967 C C . ARG A 1 248 ? -15.472 52.995 6.731 1.00 61.45 ? 248 ARG A C 1 ATOM 1968 O O . ARG A 1 248 ? -15.705 54.086 7.249 1.00 61.05 ? 248 ARG A O 1 ATOM 1969 C CB . ARG A 1 248 ? -15.836 51.166 8.414 1.00 65.21 ? 248 ARG A CB 1 ATOM 1970 C CG . ARG A 1 248 ? -16.776 50.102 8.981 1.00 69.57 ? 248 ARG A CG 1 ATOM 1971 C CD . ARG A 1 248 ? -16.022 48.928 9.612 1.00 75.03 ? 248 ARG A CD 1 ATOM 1972 N NE . ARG A 1 248 ? -15.805 49.050 11.057 1.00 80.56 ? 248 ARG A NE 1 ATOM 1973 C CZ . ARG A 1 248 ? -14.619 49.250 11.640 1.00 83.69 ? 248 ARG A CZ 1 ATOM 1974 N NH1 . ARG A 1 248 ? -13.512 49.363 10.910 1.00 84.18 ? 248 ARG A NH1 1 ATOM 1975 N NH2 . ARG A 1 248 ? -14.535 49.312 12.965 1.00 84.71 ? 248 ARG A NH2 1 ATOM 1976 N N . GLU A 1 249 ? -14.510 52.800 5.836 1.00 60.67 ? 249 GLU A N 1 ATOM 1977 C CA . GLU A 1 249 ? -13.617 53.857 5.372 1.00 59.24 ? 249 GLU A CA 1 ATOM 1978 C C . GLU A 1 249 ? -12.827 54.526 6.490 1.00 58.17 ? 249 GLU A C 1 ATOM 1979 O O . GLU A 1 249 ? -12.910 55.739 6.688 1.00 57.64 ? 249 GLU A O 1 ATOM 1980 C CB . GLU A 1 249 ? -14.398 54.923 4.597 1.00 59.30 ? 249 GLU A CB 1 ATOM 1981 C CG . GLU A 1 249 ? -13.528 55.796 3.704 1.00 58.17 ? 249 GLU A CG 1 ATOM 1982 C CD . GLU A 1 249 ? -12.905 55.014 2.558 1.00 58.56 ? 249 GLU A CD 1 ATOM 1983 O OE1 . GLU A 1 249 ? -12.172 54.038 2.827 1.00 57.73 ? 249 GLU A OE1 1 ATOM 1984 O OE2 . GLU A 1 249 ? -13.152 55.373 1.387 1.00 58.23 ? 249 GLU A OE2 1 ATOM 1985 N N . ASN A 1 250 ? -12.075 53.727 7.236 1.00 56.90 ? 250 ASN A N 1 ATOM 1986 C CA . ASN A 1 250 ? -11.244 54.268 8.297 1.00 56.11 ? 250 ASN A CA 1 ATOM 1987 C C . ASN A 1 250 ? -9.973 53.444 8.410 1.00 53.52 ? 250 ASN A C 1 ATOM 1988 O O . ASN A 1 250 ? -9.972 52.237 8.173 1.00 52.43 ? 250 ASN A O 1 ATOM 1989 C CB . ASN A 1 250 ? -11.997 54.329 9.640 1.00 59.06 ? 250 ASN A CB 1 ATOM 1990 C CG . ASN A 1 250 ? -12.672 53.021 10.006 1.00 62.08 ? 250 ASN A CG 1 ATOM 1991 O OD1 . ASN A 1 250 ? -12.013 52.013 10.284 1.00 65.33 ? 250 ASN A OD1 1 ATOM 1992 N ND2 . ASN A 1 250 ? -14.000 53.032 10.014 1.00 62.87 ? 250 ASN A ND2 1 ATOM 1993 N N . PHE A 1 251 ? -8.885 54.128 8.736 1.00 50.78 ? 251 PHE A N 1 ATOM 1994 C CA . PHE A 1 251 ? -7.581 53.511 8.877 1.00 47.89 ? 251 PHE A CA 1 ATOM 1995 C C . PHE A 1 251 ? -7.181 53.592 10.344 1.00 47.91 ? 251 PHE A C 1 ATOM 1996 O O . PHE A 1 251 ? -7.131 54.684 10.910 1.00 47.40 ? 251 PHE A O 1 ATOM 1997 C CB . PHE A 1 251 ? -6.574 54.269 8.012 1.00 45.38 ? 251 PHE A CB 1 ATOM 1998 C CG . PHE A 1 251 ? -5.153 53.880 8.256 1.00 42.44 ? 251 PHE A CG 1 ATOM 1999 C CD1 . PHE A 1 251 ? -4.715 52.591 7.972 1.00 40.81 ? 251 PHE A CD1 1 ATOM 2000 C CD2 . PHE A 1 251 ? -4.248 54.801 8.775 1.00 40.94 ? 251 PHE A CD2 1 ATOM 2001 C CE1 . PHE A 1 251 ? -3.390 52.216 8.204 1.00 39.83 ? 251 PHE A CE1 1 ATOM 2002 C CE2 . PHE A 1 251 ? -2.918 54.437 9.012 1.00 40.71 ? 251 PHE A CE2 1 ATOM 2003 C CZ . PHE A 1 251 ? -2.489 53.139 8.723 1.00 39.94 ? 251 PHE A CZ 1 ATOM 2004 N N . LEU A 1 252 ? -6.902 52.439 10.954 1.00 47.80 ? 252 LEU A N 1 ATOM 2005 C CA . LEU A 1 252 ? -6.510 52.385 12.361 1.00 47.67 ? 252 LEU A CA 1 ATOM 2006 C C . LEU A 1 252 ? -5.054 51.979 12.520 1.00 47.53 ? 252 LEU A C 1 ATOM 2007 O O . LEU A 1 252 ? -4.715 50.805 12.366 1.00 47.01 ? 252 LEU A O 1 ATOM 2008 C CB . LEU A 1 252 ? -7.365 51.377 13.137 1.00 48.14 ? 252 LEU A CB 1 ATOM 2009 C CG . LEU A 1 252 ? -8.885 51.481 13.080 1.00 48.97 ? 252 LEU A CG 1 ATOM 2010 C CD1 . LEU A 1 252 ? -9.274 52.941 13.183 1.00 49.08 ? 252 LEU A CD1 1 ATOM 2011 C CD2 . LEU A 1 252 ? -9.420 50.874 11.777 1.00 51.01 ? 252 LEU A CD2 1 ATOM 2012 N N . PRO A 1 253 ? -4.170 52.942 12.833 1.00 47.65 ? 253 PRO A N 1 ATOM 2013 C CA . PRO A 1 253 ? -2.760 52.584 12.999 1.00 49.16 ? 253 PRO A CA 1 ATOM 2014 C C . PRO A 1 253 ? -2.559 51.508 14.063 1.00 50.70 ? 253 PRO A C 1 ATOM 2015 O O . PRO A 1 253 ? -3.216 51.509 15.102 1.00 48.72 ? 253 PRO A O 1 ATOM 2016 C CB . PRO A 1 253 ? -2.096 53.921 13.341 1.00 47.48 ? 253 PRO A CB 1 ATOM 2017 C CG . PRO A 1 253 ? -3.218 54.764 13.843 1.00 46.80 ? 253 PRO A CG 1 ATOM 2018 C CD . PRO A 1 253 ? -4.362 54.393 12.966 1.00 46.05 ? 253 PRO A CD 1 ATOM 2019 N N . GLN A 1 254 ? -1.656 50.576 13.784 1.00 53.78 ? 254 GLN A N 1 ATOM 2020 C CA . GLN A 1 254 ? -1.396 49.488 14.709 1.00 55.99 ? 254 GLN A CA 1 ATOM 2021 C C . GLN A 1 254 ? -0.993 50.002 16.080 1.00 56.16 ? 254 GLN A C 1 ATOM 2022 O O . GLN A 1 254 ? -1.610 49.642 17.078 1.00 57.03 ? 254 GLN A O 1 ATOM 2023 C CB . GLN A 1 254 ? -0.310 48.565 14.155 1.00 57.58 ? 254 GLN A CB 1 ATOM 2024 C CG . GLN A 1 254 ? -0.764 47.121 14.051 1.00 61.50 ? 254 GLN A CG 1 ATOM 2025 C CD . GLN A 1 254 ? 0.247 46.234 13.355 1.00 64.37 ? 254 GLN A CD 1 ATOM 2026 O OE1 . GLN A 1 254 ? -0.022 45.061 13.081 1.00 66.11 ? 254 GLN A OE1 1 ATOM 2027 N NE2 . GLN A 1 254 ? 1.421 46.788 13.064 1.00 65.79 ? 254 GLN A NE2 1 ATOM 2028 N N . ASN A 1 255 ? 0.032 50.849 16.128 1.00 55.57 ? 255 ASN A N 1 ATOM 2029 C CA . ASN A 1 255 ? 0.522 51.405 17.391 1.00 53.15 ? 255 ASN A CA 1 ATOM 2030 C C . ASN A 1 255 ? -0.532 52.235 18.098 1.00 51.19 ? 255 ASN A C 1 ATOM 2031 O O . ASN A 1 255 ? -0.286 52.766 19.169 1.00 51.44 ? 255 ASN A O 1 ATOM 2032 C CB . ASN A 1 255 ? 1.744 52.275 17.133 1.00 54.55 ? 255 ASN A CB 1 ATOM 2033 C CG . ASN A 1 255 ? 1.475 53.340 16.093 1.00 57.98 ? 255 ASN A CG 1 ATOM 2034 O OD1 . ASN A 1 255 ? 1.019 53.037 14.982 1.00 60.91 ? 255 ASN A OD1 1 ATOM 2035 N ND2 . ASN A 1 255 ? 1.752 54.593 16.438 1.00 58.08 ? 255 ASN A ND2 1 ATOM 2036 N N . GLY A 1 256 ? -1.704 52.355 17.491 1.00 50.16 ? 256 GLY A N 1 ATOM 2037 C CA . GLY A 1 256 ? -2.766 53.132 18.099 1.00 48.21 ? 256 GLY A CA 1 ATOM 2038 C C . GLY A 1 256 ? -2.374 54.579 18.301 1.00 47.26 ? 256 GLY A C 1 ATOM 2039 O O . GLY A 1 256 ? -2.911 55.241 19.177 1.00 48.05 ? 256 GLY A O 1 ATOM 2040 N N . LEU A 1 257 ? -1.441 55.077 17.497 1.00 46.45 ? 257 LEU A N 1 ATOM 2041 C CA . LEU A 1 257 ? -1.001 56.458 17.632 1.00 47.10 ? 257 LEU A CA 1 ATOM 2042 C C . LEU A 1 257 ? -1.051 57.200 16.310 1.00 48.31 ? 257 LEU A C 1 ATOM 2043 O O . LEU A 1 257 ? -0.624 56.674 15.278 1.00 49.06 ? 257 LEU A O 1 ATOM 2044 C CB . LEU A 1 257 ? 0.439 56.519 18.140 1.00 47.19 ? 257 LEU A CB 1 ATOM 2045 C CG . LEU A 1 257 ? 0.908 55.603 19.269 1.00 46.91 ? 257 LEU A CG 1 ATOM 2046 C CD1 . LEU A 1 257 ? 2.385 55.873 19.498 1.00 46.28 ? 257 LEU A CD1 1 ATOM 2047 C CD2 . LEU A 1 257 ? 0.100 55.839 20.545 1.00 46.30 ? 257 LEU A CD2 1 ATOM 2048 N N . SER A 1 258 ? -1.554 58.429 16.348 1.00 48.91 ? 258 SER A N 1 ATOM 2049 C CA . SER A 1 258 ? -1.630 59.260 15.153 1.00 50.71 ? 258 SER A CA 1 ATOM 2050 C C . SER A 1 258 ? -0.194 59.742 14.898 1.00 50.43 ? 258 SER A C 1 ATOM 2051 O O . SER A 1 258 ? 0.569 59.922 15.852 1.00 50.37 ? 258 SER A O 1 ATOM 2052 C CB . SER A 1 258 ? -2.569 60.450 15.414 1.00 53.24 ? 258 SER A CB 1 ATOM 2053 O OG . SER A 1 258 ? -2.926 61.131 14.217 1.00 56.78 ? 258 SER A OG 1 ATOM 2054 N N . LEU A 1 259 ? 0.184 59.931 13.630 1.00 49.35 ? 259 LEU A N 1 ATOM 2055 C CA . LEU A 1 259 ? 1.542 60.382 13.304 1.00 47.59 ? 259 LEU A CA 1 ATOM 2056 C C . LEU A 1 259 ? 1.900 61.697 13.995 1.00 46.68 ? 259 LEU A C 1 ATOM 2057 O O . LEU A 1 259 ? 1.048 62.565 14.214 1.00 46.49 ? 259 LEU A O 1 ATOM 2058 C CB . LEU A 1 259 ? 1.731 60.515 11.786 1.00 47.03 ? 259 LEU A CB 1 ATOM 2059 C CG . LEU A 1 259 ? 2.043 59.221 11.013 1.00 46.20 ? 259 LEU A CG 1 ATOM 2060 C CD1 . LEU A 1 259 ? 2.082 59.511 9.526 1.00 44.61 ? 259 LEU A CD1 1 ATOM 2061 C CD2 . LEU A 1 259 ? 3.370 58.645 11.472 1.00 44.47 ? 259 LEU A CD2 1 ATOM 2062 N N . THR A 1 260 ? 3.176 61.840 14.329 1.00 44.64 ? 260 THR A N 1 ATOM 2063 C CA . THR A 1 260 ? 3.648 63.018 15.034 1.00 42.91 ? 260 THR A CA 1 ATOM 2064 C C . THR A 1 260 ? 4.839 63.675 14.371 1.00 42.40 ? 260 THR A C 1 ATOM 2065 O O . THR A 1 260 ? 4.900 64.897 14.246 1.00 42.44 ? 260 THR A O 1 ATOM 2066 C CB . THR A 1 260 ? 4.103 62.653 16.446 1.00 42.13 ? 260 THR A CB 1 ATOM 2067 O OG1 . THR A 1 260 ? 3.408 61.485 16.884 1.00 41.74 ? 260 THR A OG1 1 ATOM 2068 C CG2 . THR A 1 260 ? 3.828 63.783 17.397 1.00 42.55 ? 260 THR A CG2 1 ATOM 2069 N N . GLY A 1 261 ? 5.792 62.853 13.960 1.00 41.29 ? 261 GLY A N 1 ATOM 2070 C CA . GLY A 1 261 ? 6.999 63.381 13.374 1.00 42.06 ? 261 GLY A CA 1 ATOM 2071 C C . GLY A 1 261 ? 7.977 63.482 14.530 1.00 42.66 ? 261 GLY A C 1 ATOM 2072 O O . GLY A 1 261 ? 8.979 64.194 14.453 1.00 43.25 ? 261 GLY A O 1 ATOM 2073 N N . SER A 1 262 ? 7.644 62.777 15.613 1.00 42.53 ? 262 SER A N 1 ATOM 2074 C CA . SER A 1 262 ? 8.453 62.717 16.828 1.00 43.05 ? 262 SER A CA 1 ATOM 2075 C C . SER A 1 262 ? 9.300 61.451 16.732 1.00 45.21 ? 262 SER A C 1 ATOM 2076 O O . SER A 1 262 ? 9.103 60.645 15.816 1.00 45.96 ? 262 SER A O 1 ATOM 2077 C CB . SER A 1 262 ? 7.557 62.641 18.072 1.00 40.96 ? 262 SER A CB 1 ATOM 2078 O OG . SER A 1 262 ? 6.820 61.427 18.125 1.00 37.79 ? 262 SER A OG 1 ATOM 2079 N N . THR A 1 263 ? 10.232 61.269 17.668 1.00 45.96 ? 263 THR A N 1 ATOM 2080 C CA . THR A 1 263 ? 11.101 60.091 17.654 1.00 44.57 ? 263 THR A CA 1 ATOM 2081 C C . THR A 1 263 ? 10.304 58.813 17.907 1.00 43.85 ? 263 THR A C 1 ATOM 2082 O O . THR A 1 263 ? 10.871 57.733 18.016 1.00 42.68 ? 263 THR A O 1 ATOM 2083 C CB . THR A 1 263 ? 12.220 60.205 18.713 1.00 44.83 ? 263 THR A CB 1 ATOM 2084 O OG1 . THR A 1 263 ? 11.649 60.120 20.024 1.00 46.54 ? 263 THR A OG1 1 ATOM 2085 C CG2 . THR A 1 263 ? 12.955 61.531 18.574 1.00 42.94 ? 263 THR A CG2 1 ATOM 2086 N N . LEU A 1 264 ? 8.986 58.944 18.003 1.00 44.10 ? 264 LEU A N 1 ATOM 2087 C CA . LEU A 1 264 ? 8.127 57.791 18.236 1.00 45.37 ? 264 LEU A CA 1 ATOM 2088 C C . LEU A 1 264 ? 7.684 57.151 16.930 1.00 45.87 ? 264 LEU A C 1 ATOM 2089 O O . LEU A 1 264 ? 7.354 55.965 16.896 1.00 47.15 ? 264 LEU A O 1 ATOM 2090 C CB . LEU A 1 264 ? 6.886 58.209 19.023 1.00 46.06 ? 264 LEU A CB 1 ATOM 2091 C CG . LEU A 1 264 ? 6.859 57.979 20.532 1.00 46.36 ? 264 LEU A CG 1 ATOM 2092 C CD1 . LEU A 1 264 ? 8.257 58.163 21.109 1.00 46.51 ? 264 LEU A CD1 1 ATOM 2093 C CD2 . LEU A 1 264 ? 5.848 58.943 21.157 1.00 46.93 ? 264 LEU A CD2 1 ATOM 2094 N N . ASP A 1 265 ? 7.678 57.936 15.856 1.00 45.81 ? 265 ASP A N 1 ATOM 2095 C CA . ASP A 1 265 ? 7.243 57.437 14.554 1.00 45.02 ? 265 ASP A CA 1 ATOM 2096 C C . ASP A 1 265 ? 8.341 56.824 13.699 1.00 42.86 ? 265 ASP A C 1 ATOM 2097 O O . ASP A 1 265 ? 9.526 57.096 13.894 1.00 43.90 ? 265 ASP A O 1 ATOM 2098 C CB . ASP A 1 265 ? 6.551 58.558 13.784 1.00 46.24 ? 265 ASP A CB 1 ATOM 2099 C CG . ASP A 1 265 ? 5.367 59.131 14.543 1.00 48.65 ? 265 ASP A CG 1 ATOM 2100 O OD1 . ASP A 1 265 ? 4.469 58.354 14.933 1.00 49.53 ? 265 ASP A OD1 1 ATOM 2101 O OD2 . ASP A 1 265 ? 5.336 60.359 14.753 1.00 50.82 ? 265 ASP A OD2 1 ATOM 2102 N N . LEU A 1 266 ? 7.931 55.987 12.752 1.00 39.65 ? 266 LEU A N 1 ATOM 2103 C CA . LEU A 1 266 ? 8.867 55.322 11.855 1.00 37.17 ? 266 LEU A CA 1 ATOM 2104 C C . LEU A 1 266 ? 9.129 56.096 10.559 1.00 36.07 ? 266 LEU A C 1 ATOM 2105 O O . LEU A 1 266 ? 8.311 56.900 10.110 1.00 34.88 ? 266 LEU A O 1 ATOM 2106 C CB . LEU A 1 266 ? 8.348 53.919 11.512 1.00 36.22 ? 266 LEU A CB 1 ATOM 2107 C CG . LEU A 1 266 ? 8.478 52.783 12.529 1.00 34.12 ? 266 LEU A CG 1 ATOM 2108 C CD1 . LEU A 1 266 ? 7.656 51.592 12.083 1.00 32.00 ? 266 LEU A CD1 1 ATOM 2109 C CD2 . LEU A 1 266 ? 9.939 52.382 12.669 1.00 33.79 ? 266 LEU A CD2 1 ATOM 2110 N N . ARG A 1 267 ? 10.286 55.841 9.962 1.00 35.11 ? 267 ARG A N 1 ATOM 2111 C CA . ARG A 1 267 ? 10.659 56.475 8.704 1.00 34.54 ? 267 ARG A CA 1 ATOM 2112 C C . ARG A 1 267 ? 11.180 55.408 7.751 1.00 34.27 ? 267 ARG A C 1 ATOM 2113 O O . ARG A 1 267 ? 11.629 54.350 8.191 1.00 34.08 ? 267 ARG A O 1 ATOM 2114 C CB . ARG A 1 267 ? 11.782 57.473 8.901 1.00 32.77 ? 267 ARG A CB 1 ATOM 2115 C CG . ARG A 1 267 ? 11.492 58.659 9.750 1.00 30.26 ? 267 ARG A CG 1 ATOM 2116 C CD . ARG A 1 267 ? 12.654 59.579 9.535 1.00 30.37 ? 267 ARG A CD 1 ATOM 2117 N NE . ARG A 1 267 ? 12.749 60.646 10.507 1.00 31.78 ? 267 ARG A NE 1 ATOM 2118 C CZ . ARG A 1 267 ? 13.765 61.494 10.540 1.00 32.26 ? 267 ARG A CZ 1 ATOM 2119 N NH1 . ARG A 1 267 ? 14.745 61.374 9.649 1.00 30.39 ? 267 ARG A NH1 1 ATOM 2120 N NH2 . ARG A 1 267 ? 13.804 62.450 11.459 1.00 32.93 ? 267 ARG A NH2 1 ATOM 2121 N N . TYR A 1 268 ? 11.128 55.666 6.452 1.00 33.15 ? 268 TYR A N 1 ATOM 2122 C CA . TYR A 1 268 ? 11.675 54.685 5.545 1.00 34.01 ? 268 TYR A CA 1 ATOM 2123 C C . TYR A 1 268 ? 13.185 54.761 5.778 1.00 35.94 ? 268 TYR A C 1 ATOM 2124 O O . TYR A 1 268 ? 13.822 53.788 6.184 1.00 37.41 ? 268 TYR A O 1 ATOM 2125 C CB . TYR A 1 268 ? 11.386 55.042 4.093 1.00 32.78 ? 268 TYR A CB 1 ATOM 2126 C CG . TYR A 1 268 ? 9.996 54.755 3.598 1.00 32.80 ? 268 TYR A CG 1 ATOM 2127 C CD1 . TYR A 1 268 ? 9.475 53.463 3.613 1.00 33.19 ? 268 TYR A CD1 1 ATOM 2128 C CD2 . TYR A 1 268 ? 9.234 55.763 3.018 1.00 33.09 ? 268 TYR A CD2 1 ATOM 2129 C CE1 . TYR A 1 268 ? 8.227 53.181 3.049 1.00 32.71 ? 268 TYR A CE1 1 ATOM 2130 C CE2 . TYR A 1 268 ? 7.992 55.499 2.453 1.00 31.90 ? 268 TYR A CE2 1 ATOM 2131 C CZ . TYR A 1 268 ? 7.495 54.206 2.468 1.00 32.49 ? 268 TYR A CZ 1 ATOM 2132 O OH . TYR A 1 268 ? 6.283 53.930 1.879 1.00 31.84 ? 268 TYR A OH 1 ATOM 2133 N N . ASP A 1 269 ? 13.742 55.944 5.536 1.00 37.17 ? 269 ASP A N 1 ATOM 2134 C CA . ASP A 1 269 ? 15.173 56.205 5.672 1.00 37.67 ? 269 ASP A CA 1 ATOM 2135 C C . ASP A 1 269 ? 15.336 57.290 6.737 1.00 37.28 ? 269 ASP A C 1 ATOM 2136 O O . ASP A 1 269 ? 14.398 58.042 6.992 1.00 37.69 ? 269 ASP A O 1 ATOM 2137 C CB . ASP A 1 269 ? 15.711 56.710 4.326 1.00 39.80 ? 269 ASP A CB 1 ATOM 2138 C CG . ASP A 1 269 ? 17.224 56.599 4.200 1.00 42.94 ? 269 ASP A CG 1 ATOM 2139 O OD1 . ASP A 1 269 ? 17.695 55.653 3.534 1.00 44.45 ? 269 ASP A OD1 1 ATOM 2140 O OD2 . ASP A 1 269 ? 17.947 57.458 4.754 1.00 45.53 ? 269 ASP A OD2 1 ATOM 2141 N N . TYR A 1 270 ? 16.517 57.385 7.345 1.00 36.76 ? 270 TYR A N 1 ATOM 2142 C CA . TYR A 1 270 ? 16.765 58.390 8.379 1.00 36.40 ? 270 TYR A CA 1 ATOM 2143 C C . TYR A 1 270 ? 17.796 59.443 7.989 1.00 37.16 ? 270 TYR A C 1 ATOM 2144 O O . TYR A 1 270 ? 18.307 60.163 8.846 1.00 39.40 ? 270 TYR A O 1 ATOM 2145 C CB . TYR A 1 270 ? 17.186 57.709 9.686 1.00 34.77 ? 270 TYR A CB 1 ATOM 2146 C CG . TYR A 1 270 ? 16.050 56.943 10.319 1.00 33.87 ? 270 TYR A CG 1 ATOM 2147 C CD1 . TYR A 1 270 ? 15.016 57.612 10.972 1.00 31.52 ? 270 TYR A CD1 1 ATOM 2148 C CD2 . TYR A 1 270 ? 15.945 55.559 10.167 1.00 33.82 ? 270 TYR A CD2 1 ATOM 2149 C CE1 . TYR A 1 270 ? 13.895 56.924 11.452 1.00 32.46 ? 270 TYR A CE1 1 ATOM 2150 C CE2 . TYR A 1 270 ? 14.824 54.858 10.640 1.00 34.09 ? 270 TYR A CE2 1 ATOM 2151 C CZ . TYR A 1 270 ? 13.800 55.547 11.279 1.00 33.56 ? 270 TYR A CZ 1 ATOM 2152 O OH . TYR A 1 270 ? 12.674 54.863 11.708 1.00 32.08 ? 270 TYR A OH 1 ATOM 2153 N N . GLY A 1 271 ? 18.103 59.536 6.700 1.00 36.47 ? 271 GLY A N 1 ATOM 2154 C CA . GLY A 1 271 ? 19.064 60.521 6.240 1.00 36.05 ? 271 GLY A CA 1 ATOM 2155 C C . GLY A 1 271 ? 18.399 61.354 5.167 1.00 36.28 ? 271 GLY A C 1 ATOM 2156 O O . GLY A 1 271 ? 17.239 61.734 5.320 1.00 36.92 ? 271 GLY A O 1 ATOM 2157 N N . GLN A 1 272 ? 19.121 61.646 4.089 1.00 35.50 ? 272 GLN A N 1 ATOM 2158 C CA . GLN A 1 272 ? 18.564 62.418 2.984 1.00 35.14 ? 272 GLN A CA 1 ATOM 2159 C C . GLN A 1 272 ? 17.618 61.524 2.204 1.00 34.72 ? 272 GLN A C 1 ATOM 2160 O O . GLN A 1 272 ? 18.044 60.705 1.401 1.00 36.59 ? 272 GLN A O 1 ATOM 2161 C CB . GLN A 1 272 ? 19.677 62.904 2.065 1.00 36.48 ? 272 GLN A CB 1 ATOM 2162 C CG . GLN A 1 272 ? 20.478 64.035 2.652 1.00 39.47 ? 272 GLN A CG 1 ATOM 2163 C CD . GLN A 1 272 ? 19.592 65.196 3.020 1.00 41.35 ? 272 GLN A CD 1 ATOM 2164 O OE1 . GLN A 1 272 ? 18.846 65.712 2.182 1.00 43.54 ? 272 GLN A OE1 1 ATOM 2165 N NE2 . GLN A 1 272 ? 19.656 65.613 4.279 1.00 41.54 ? 272 GLN A NE2 1 ATOM 2166 N N . PHE A 1 273 ? 16.327 61.690 2.422 1.00 33.18 ? 273 PHE A N 1 ATOM 2167 C CA . PHE A 1 273 ? 15.370 60.838 1.748 1.00 33.01 ? 273 PHE A CA 1 ATOM 2168 C C . PHE A 1 273 ? 14.037 61.558 1.757 1.00 34.25 ? 273 PHE A C 1 ATOM 2169 O O . PHE A 1 273 ? 13.431 61.705 2.819 1.00 34.73 ? 273 PHE A O 1 ATOM 2170 C CB . PHE A 1 273 ? 15.271 59.537 2.536 1.00 32.36 ? 273 PHE A CB 1 ATOM 2171 C CG . PHE A 1 273 ? 14.740 58.377 1.757 1.00 32.23 ? 273 PHE A CG 1 ATOM 2172 C CD1 . PHE A 1 273 ? 15.577 57.637 0.928 1.00 32.10 ? 273 PHE A CD1 1 ATOM 2173 C CD2 . PHE A 1 273 ? 13.417 57.973 1.917 1.00 31.76 ? 273 PHE A CD2 1 ATOM 2174 C CE1 . PHE A 1 273 ? 15.103 56.508 0.266 1.00 32.78 ? 273 PHE A CE1 1 ATOM 2175 C CE2 . PHE A 1 273 ? 12.926 56.847 1.263 1.00 31.83 ? 273 PHE A CE2 1 ATOM 2176 C CZ . PHE A 1 273 ? 13.771 56.108 0.442 1.00 33.44 ? 273 PHE A CZ 1 ATOM 2177 N N . TYR A 1 274 ? 13.579 62.018 0.594 1.00 35.92 ? 274 TYR A N 1 ATOM 2178 C CA . TYR A 1 274 ? 12.300 62.720 0.535 1.00 38.16 ? 274 TYR A CA 1 ATOM 2179 C C . TYR A 1 274 ? 11.399 62.406 -0.665 1.00 38.31 ? 274 TYR A C 1 ATOM 2180 O O . TYR A 1 274 ? 11.845 61.864 -1.685 1.00 37.38 ? 274 TYR A O 1 ATOM 2181 C CB . TYR A 1 274 ? 12.514 64.237 0.610 1.00 41.47 ? 274 TYR A CB 1 ATOM 2182 C CG . TYR A 1 274 ? 11.357 64.922 1.298 1.00 47.00 ? 274 TYR A CG 1 ATOM 2183 C CD1 . TYR A 1 274 ? 11.004 64.569 2.598 1.00 49.83 ? 274 TYR A CD1 1 ATOM 2184 C CD2 . TYR A 1 274 ? 10.586 65.881 0.646 1.00 49.08 ? 274 TYR A CD2 1 ATOM 2185 C CE1 . TYR A 1 274 ? 9.917 65.144 3.235 1.00 52.36 ? 274 TYR A CE1 1 ATOM 2186 C CE2 . TYR A 1 274 ? 9.488 66.469 1.276 1.00 51.50 ? 274 TYR A CE2 1 ATOM 2187 C CZ . TYR A 1 274 ? 9.161 66.091 2.573 1.00 53.40 ? 274 TYR A CZ 1 ATOM 2188 O OH . TYR A 1 274 ? 8.081 66.655 3.222 1.00 57.31 ? 274 TYR A OH 1 ATOM 2189 N N . ALA A 1 275 ? 10.121 62.747 -0.516 1.00 37.60 ? 275 ALA A N 1 ATOM 2190 C CA . ALA A 1 275 ? 9.129 62.542 -1.556 1.00 37.45 ? 275 ALA A CA 1 ATOM 2191 C C . ALA A 1 275 ? 9.063 61.097 -2.046 1.00 37.87 ? 275 ALA A C 1 ATOM 2192 O O . ALA A 1 275 ? 8.743 60.843 -3.207 1.00 40.07 ? 275 ALA A O 1 ATOM 2193 C CB . ALA A 1 275 ? 9.418 63.474 -2.722 1.00 36.27 ? 275 ALA A CB 1 ATOM 2194 N N . SER A 1 276 ? 9.349 60.148 -1.165 1.00 37.06 ? 276 SER A N 1 ATOM 2195 C CA . SER A 1 276 ? 9.315 58.740 -1.540 1.00 35.55 ? 276 SER A CA 1 ATOM 2196 C C . SER A 1 276 ? 7.937 58.300 -2.027 1.00 36.01 ? 276 SER A C 1 ATOM 2197 O O . SER A 1 276 ? 6.901 58.702 -1.475 1.00 36.52 ? 276 SER A O 1 ATOM 2198 C CB . SER A 1 276 ? 9.731 57.871 -0.354 1.00 35.37 ? 276 SER A CB 1 ATOM 2199 O OG . SER A 1 276 ? 8.891 58.101 0.761 1.00 33.17 ? 276 SER A OG 1 ATOM 2200 N N . LYS A 1 277 ? 7.946 57.470 -3.069 1.00 35.32 ? 277 LYS A N 1 ATOM 2201 C CA . LYS A 1 277 ? 6.731 56.923 -3.675 1.00 33.58 ? 277 LYS A CA 1 ATOM 2202 C C . LYS A 1 277 ? 6.975 55.490 -4.157 1.00 32.73 ? 277 LYS A C 1 ATOM 2203 O O . LYS A 1 277 ? 7.980 55.216 -4.813 1.00 32.82 ? 277 LYS A O 1 ATOM 2204 C CB . LYS A 1 277 ? 6.298 57.789 -4.851 1.00 31.35 ? 277 LYS A CB 1 ATOM 2205 C CG . LYS A 1 277 ? 5.008 57.328 -5.477 1.00 30.59 ? 277 LYS A CG 1 ATOM 2206 C CD . LYS A 1 277 ? 4.497 58.341 -6.485 1.00 31.03 ? 277 LYS A CD 1 ATOM 2207 C CE . LYS A 1 277 ? 4.054 59.632 -5.830 1.00 28.67 ? 277 LYS A CE 1 ATOM 2208 N NZ . LYS A 1 277 ? 2.904 59.399 -4.908 1.00 30.59 ? 277 LYS A NZ 1 ATOM 2209 N N . SER A 1 278 ? 6.066 54.576 -3.827 1.00 31.49 ? 278 SER A N 1 ATOM 2210 C CA . SER A 1 278 ? 6.208 53.181 -4.241 1.00 30.99 ? 278 SER A CA 1 ATOM 2211 C C . SER A 1 278 ? 5.236 52.867 -5.369 1.00 32.45 ? 278 SER A C 1 ATOM 2212 O O . SER A 1 278 ? 4.420 53.708 -5.754 1.00 33.42 ? 278 SER A O 1 ATOM 2213 C CB . SER A 1 278 ? 5.920 52.242 -3.066 1.00 29.90 ? 278 SER A CB 1 ATOM 2214 O OG . SER A 1 278 ? 4.596 52.410 -2.584 1.00 25.55 ? 278 SER A OG 1 ATOM 2215 N N . PHE A 1 279 ? 5.347 51.655 -5.900 1.00 32.06 ? 279 PHE A N 1 ATOM 2216 C CA . PHE A 1 279 ? 4.470 51.181 -6.958 1.00 32.47 ? 279 PHE A CA 1 ATOM 2217 C C . PHE A 1 279 ? 4.615 49.669 -6.955 1.00 34.54 ? 279 PHE A C 1 ATOM 2218 O O . PHE A 1 279 ? 5.600 49.141 -6.444 1.00 36.35 ? 279 PHE A O 1 ATOM 2219 C CB . PHE A 1 279 ? 4.876 51.775 -8.305 1.00 30.59 ? 279 PHE A CB 1 ATOM 2220 C CG . PHE A 1 279 ? 6.069 51.134 -8.909 1.00 31.48 ? 279 PHE A CG 1 ATOM 2221 C CD1 . PHE A 1 279 ? 5.925 50.079 -9.803 1.00 32.79 ? 279 PHE A CD1 1 ATOM 2222 C CD2 . PHE A 1 279 ? 7.346 51.579 -8.589 1.00 31.83 ? 279 PHE A CD2 1 ATOM 2223 C CE1 . PHE A 1 279 ? 7.046 49.473 -10.381 1.00 33.60 ? 279 PHE A CE1 1 ATOM 2224 C CE2 . PHE A 1 279 ? 8.475 50.985 -9.156 1.00 32.28 ? 279 PHE A CE2 1 ATOM 2225 C CZ . PHE A 1 279 ? 8.324 49.930 -10.054 1.00 32.93 ? 279 PHE A CZ 1 ATOM 2226 N N . PHE A 1 280 ? 3.632 48.973 -7.506 1.00 35.76 ? 280 PHE A N 1 ATOM 2227 C CA . PHE A 1 280 ? 3.660 47.519 -7.533 1.00 36.72 ? 280 PHE A CA 1 ATOM 2228 C C . PHE A 1 280 ? 4.296 46.983 -8.808 1.00 37.64 ? 280 PHE A C 1 ATOM 2229 O O . PHE A 1 280 ? 3.990 47.440 -9.904 1.00 39.40 ? 280 PHE A O 1 ATOM 2230 C CB . PHE A 1 280 ? 2.233 46.994 -7.401 1.00 38.02 ? 280 PHE A CB 1 ATOM 2231 C CG . PHE A 1 280 ? 2.117 45.506 -7.481 1.00 39.47 ? 280 PHE A CG 1 ATOM 2232 C CD1 . PHE A 1 280 ? 2.871 44.688 -6.645 1.00 40.19 ? 280 PHE A CD1 1 ATOM 2233 C CD2 . PHE A 1 280 ? 1.219 44.917 -8.369 1.00 39.41 ? 280 PHE A CD2 1 ATOM 2234 C CE1 . PHE A 1 280 ? 2.731 43.299 -6.687 1.00 41.15 ? 280 PHE A CE1 1 ATOM 2235 C CE2 . PHE A 1 280 ? 1.069 43.533 -8.419 1.00 40.01 ? 280 PHE A CE2 1 ATOM 2236 C CZ . PHE A 1 280 ? 1.828 42.721 -7.576 1.00 40.60 ? 280 PHE A CZ 1 ATOM 2237 N N . ASP A 1 281 ? 5.189 46.016 -8.659 1.00 38.63 ? 281 ASP A N 1 ATOM 2238 C CA . ASP A 1 281 ? 5.855 45.392 -9.799 1.00 39.86 ? 281 ASP A CA 1 ATOM 2239 C C . ASP A 1 281 ? 5.252 43.993 -9.933 1.00 41.42 ? 281 ASP A C 1 ATOM 2240 O O . ASP A 1 281 ? 5.766 43.028 -9.368 1.00 42.37 ? 281 ASP A O 1 ATOM 2241 C CB . ASP A 1 281 ? 7.364 45.313 -9.535 1.00 38.08 ? 281 ASP A CB 1 ATOM 2242 C CG . ASP A 1 281 ? 8.117 44.553 -10.612 1.00 36.57 ? 281 ASP A CG 1 ATOM 2243 O OD1 . ASP A 1 281 ? 7.483 44.080 -11.574 1.00 35.84 ? 281 ASP A OD1 1 ATOM 2244 O OD2 . ASP A 1 281 ? 9.353 44.426 -10.492 1.00 35.83 ? 281 ASP A OD2 1 ATOM 2245 N N . ASP A 1 282 ? 4.152 43.891 -10.669 1.00 42.58 ? 282 ASP A N 1 ATOM 2246 C CA . ASP A 1 282 ? 3.474 42.611 -10.833 1.00 44.80 ? 282 ASP A CA 1 ATOM 2247 C C . ASP A 1 282 ? 4.321 41.613 -11.592 1.00 44.12 ? 282 ASP A C 1 ATOM 2248 O O . ASP A 1 282 ? 4.057 40.411 -11.550 1.00 46.34 ? 282 ASP A O 1 ATOM 2249 C CB . ASP A 1 282 ? 2.160 42.797 -11.576 1.00 47.67 ? 282 ASP A CB 1 ATOM 2250 C CG . ASP A 1 282 ? 2.370 43.186 -13.018 1.00 52.97 ? 282 ASP A CG 1 ATOM 2251 O OD1 . ASP A 1 282 ? 2.878 44.307 -13.271 1.00 56.40 ? 282 ASP A OD1 1 ATOM 2252 O OD2 . ASP A 1 282 ? 2.035 42.364 -13.899 1.00 55.53 ? 282 ASP A OD2 1 ATOM 2253 N N . ALA A 1 283 ? 5.337 42.100 -12.291 1.00 42.21 ? 283 ALA A N 1 ATOM 2254 C CA . ALA A 1 283 ? 6.190 41.208 -13.059 1.00 40.25 ? 283 ALA A CA 1 ATOM 2255 C C . ALA A 1 283 ? 7.083 40.397 -12.148 1.00 39.84 ? 283 ALA A C 1 ATOM 2256 O O . ALA A 1 283 ? 7.556 39.338 -12.530 1.00 40.65 ? 283 ALA A O 1 ATOM 2257 C CB . ALA A 1 283 ? 7.028 41.997 -14.028 1.00 41.37 ? 283 ALA A CB 1 ATOM 2258 N N . LYS A 1 284 ? 7.322 40.903 -10.945 1.00 39.36 ? 284 LYS A N 1 ATOM 2259 C CA . LYS A 1 284 ? 8.157 40.207 -9.985 1.00 38.01 ? 284 LYS A CA 1 ATOM 2260 C C . LYS A 1 284 ? 7.474 40.160 -8.628 1.00 39.27 ? 284 LYS A C 1 ATOM 2261 O O . LYS A 1 284 ? 8.093 39.808 -7.629 1.00 39.44 ? 284 LYS A O 1 ATOM 2262 C CB . LYS A 1 284 ? 9.514 40.900 -9.864 1.00 35.52 ? 284 LYS A CB 1 ATOM 2263 C CG . LYS A 1 284 ? 10.440 40.659 -11.039 1.00 33.98 ? 284 LYS A CG 1 ATOM 2264 C CD . LYS A 1 284 ? 11.894 40.875 -10.632 1.00 36.94 ? 284 LYS A CD 1 ATOM 2265 C CE . LYS A 1 284 ? 12.869 40.502 -11.759 1.00 39.43 ? 284 LYS A CE 1 ATOM 2266 N NZ . LYS A 1 284 ? 14.321 40.673 -11.403 1.00 38.87 ? 284 LYS A NZ 1 ATOM 2267 N N . ASN A 1 285 ? 6.192 40.514 -8.603 1.00 41.28 ? 285 ASN A N 1 ATOM 2268 C CA . ASN A 1 285 ? 5.402 40.525 -7.372 1.00 42.57 ? 285 ASN A CA 1 ATOM 2269 C C . ASN A 1 285 ? 6.173 41.115 -6.211 1.00 41.45 ? 285 ASN A C 1 ATOM 2270 O O . ASN A 1 285 ? 6.540 40.409 -5.270 1.00 40.75 ? 285 ASN A O 1 ATOM 2271 C CB . ASN A 1 285 ? 4.954 39.113 -7.028 1.00 45.82 ? 285 ASN A CB 1 ATOM 2272 C CG . ASN A 1 285 ? 4.082 38.529 -8.097 1.00 51.46 ? 285 ASN A CG 1 ATOM 2273 O OD1 . ASN A 1 285 ? 3.013 39.069 -8.398 1.00 54.55 ? 285 ASN A OD1 1 ATOM 2274 N ND2 . ASN A 1 285 ? 4.534 37.430 -8.703 1.00 55.07 ? 285 ASN A ND2 1 ATOM 2275 N N . ARG A 1 286 ? 6.415 42.417 -6.293 1.00 39.69 ? 286 ARG A N 1 ATOM 2276 C CA . ARG A 1 286 ? 7.148 43.131 -5.259 1.00 38.59 ? 286 ARG A CA 1 ATOM 2277 C C . ARG A 1 286 ? 6.739 44.586 -5.326 1.00 38.30 ? 286 ARG A C 1 ATOM 2278 O O . ARG A 1 286 ? 6.191 45.033 -6.337 1.00 39.01 ? 286 ARG A O 1 ATOM 2279 C CB . ARG A 1 286 ? 8.653 43.036 -5.512 1.00 34.60 ? 286 ARG A CB 1 ATOM 2280 C CG . ARG A 1 286 ? 9.052 43.680 -6.808 1.00 30.58 ? 286 ARG A CG 1 ATOM 2281 C CD . ARG A 1 286 ? 10.537 43.616 -7.048 1.00 31.72 ? 286 ARG A CD 1 ATOM 2282 N NE . ARG A 1 286 ? 10.858 44.013 -8.418 1.00 33.33 ? 286 ARG A NE 1 ATOM 2283 C CZ . ARG A 1 286 ? 12.070 43.941 -8.958 1.00 33.03 ? 286 ARG A CZ 1 ATOM 2284 N NH1 . ARG A 1 286 ? 13.087 43.485 -8.237 1.00 35.71 ? 286 ARG A NH1 1 ATOM 2285 N NH2 . ARG A 1 286 ? 12.259 44.317 -10.216 1.00 31.74 ? 286 ARG A NH2 1 ATOM 2286 N N . ARG A 1 287 ? 6.991 45.320 -4.249 1.00 36.80 ? 287 ARG A N 1 ATOM 2287 C CA . ARG A 1 287 ? 6.687 46.741 -4.239 1.00 35.13 ? 287 ARG A CA 1 ATOM 2288 C C . ARG A 1 287 ? 8.029 47.457 -4.271 1.00 34.99 ? 287 ARG A C 1 ATOM 2289 O O . ARG A 1 287 ? 8.921 47.157 -3.473 1.00 35.71 ? 287 ARG A O 1 ATOM 2290 C CB . ARG A 1 287 ? 5.909 47.123 -2.985 1.00 32.84 ? 287 ARG A CB 1 ATOM 2291 C CG . ARG A 1 287 ? 5.653 48.607 -2.847 1.00 29.68 ? 287 ARG A CG 1 ATOM 2292 C CD . ARG A 1 287 ? 4.506 48.820 -1.899 1.00 28.51 ? 287 ARG A CD 1 ATOM 2293 N NE . ARG A 1 287 ? 3.253 48.343 -2.467 1.00 27.35 ? 287 ARG A NE 1 ATOM 2294 C CZ . ARG A 1 287 ? 2.478 49.077 -3.261 1.00 28.67 ? 287 ARG A CZ 1 ATOM 2295 N NH1 . ARG A 1 287 ? 2.831 50.321 -3.566 1.00 28.76 ? 287 ARG A NH1 1 ATOM 2296 N NH2 . ARG A 1 287 ? 1.356 48.568 -3.762 1.00 26.78 ? 287 ARG A NH2 1 ATOM 2297 N N . VAL A 1 288 ? 8.185 48.380 -5.211 1.00 33.66 ? 288 VAL A N 1 ATOM 2298 C CA . VAL A 1 288 ? 9.430 49.115 -5.326 1.00 33.48 ? 288 VAL A CA 1 ATOM 2299 C C . VAL A 1 288 ? 9.262 50.547 -4.825 1.00 33.99 ? 288 VAL A C 1 ATOM 2300 O O . VAL A 1 288 ? 8.282 51.225 -5.140 1.00 33.55 ? 288 VAL A O 1 ATOM 2301 C CB . VAL A 1 288 ? 9.931 49.106 -6.779 1.00 32.57 ? 288 VAL A CB 1 ATOM 2302 C CG1 . VAL A 1 288 ? 11.156 50.007 -6.919 1.00 32.00 ? 288 VAL A CG1 1 ATOM 2303 C CG2 . VAL A 1 288 ? 10.278 47.678 -7.183 1.00 30.54 ? 288 VAL A CG2 1 ATOM 2304 N N . LEU A 1 289 ? 10.227 50.994 -4.030 1.00 33.66 ? 289 LEU A N 1 ATOM 2305 C CA . LEU A 1 289 ? 10.184 52.332 -3.464 1.00 33.32 ? 289 LEU A CA 1 ATOM 2306 C C . LEU A 1 289 ? 11.217 53.245 -4.108 1.00 33.93 ? 289 LEU A C 1 ATOM 2307 O O . LEU A 1 289 ? 12.397 52.898 -4.185 1.00 35.28 ? 289 LEU A O 1 ATOM 2308 C CB . LEU A 1 289 ? 10.435 52.263 -1.957 1.00 31.80 ? 289 LEU A CB 1 ATOM 2309 C CG . LEU A 1 289 ? 10.407 53.580 -1.189 1.00 30.72 ? 289 LEU A CG 1 ATOM 2310 C CD1 . LEU A 1 289 ? 9.020 54.177 -1.294 1.00 30.26 ? 289 LEU A CD1 1 ATOM 2311 C CD2 . LEU A 1 289 ? 10.777 53.359 0.270 1.00 31.07 ? 289 LEU A CD2 1 ATOM 2312 N N . TRP A 1 290 ? 10.761 54.405 -4.579 1.00 32.85 ? 290 TRP A N 1 ATOM 2313 C CA . TRP A 1 290 ? 11.621 55.413 -5.201 1.00 31.32 ? 290 TRP A CA 1 ATOM 2314 C C . TRP A 1 290 ? 11.678 56.602 -4.253 1.00 31.65 ? 290 TRP A C 1 ATOM 2315 O O . TRP A 1 290 ? 10.680 56.913 -3.610 1.00 31.95 ? 290 TRP A O 1 ATOM 2316 C CB . TRP A 1 290 ? 11.010 55.900 -6.505 1.00 30.46 ? 290 TRP A CB 1 ATOM 2317 C CG . TRP A 1 290 ? 11.317 55.088 -7.713 1.00 31.29 ? 290 TRP A CG 1 ATOM 2318 C CD1 . TRP A 1 290 ? 10.452 54.298 -8.403 1.00 30.44 ? 290 TRP A CD1 1 ATOM 2319 C CD2 . TRP A 1 290 ? 12.536 55.101 -8.462 1.00 32.14 ? 290 TRP A CD2 1 ATOM 2320 N NE1 . TRP A 1 290 ? 11.047 53.832 -9.546 1.00 31.41 ? 290 TRP A NE1 1 ATOM 2321 C CE2 . TRP A 1 290 ? 12.331 54.312 -9.608 1.00 31.47 ? 290 TRP A CE2 1 ATOM 2322 C CE3 . TRP A 1 290 ? 13.786 55.716 -8.280 1.00 33.07 ? 290 TRP A CE3 1 ATOM 2323 C CZ2 . TRP A 1 290 ? 13.329 54.115 -10.575 1.00 31.21 ? 290 TRP A CZ2 1 ATOM 2324 C CZ3 . TRP A 1 290 ? 14.781 55.520 -9.246 1.00 32.74 ? 290 TRP A CZ3 1 ATOM 2325 C CH2 . TRP A 1 290 ? 14.541 54.728 -10.375 1.00 31.29 ? 290 TRP A CH2 1 ATOM 2326 N N . ALA A 1 291 ? 12.821 57.275 -4.158 1.00 32.21 ? 291 ALA A N 1 ATOM 2327 C CA . ALA A 1 291 ? 12.911 58.449 -3.281 1.00 33.57 ? 291 ALA A CA 1 ATOM 2328 C C . ALA A 1 291 ? 13.914 59.499 -3.744 1.00 33.59 ? 291 ALA A C 1 ATOM 2329 O O . ALA A 1 291 ? 15.000 59.174 -4.232 1.00 34.76 ? 291 ALA A O 1 ATOM 2330 C CB . ALA A 1 291 ? 13.243 58.029 -1.873 1.00 33.57 ? 291 ALA A CB 1 ATOM 2331 N N . TRP A 1 292 ? 13.547 60.764 -3.590 1.00 31.53 ? 292 TRP A N 1 ATOM 2332 C CA . TRP A 1 292 ? 14.429 61.838 -3.990 1.00 30.71 ? 292 TRP A CA 1 ATOM 2333 C C . TRP A 1 292 ? 15.474 62.043 -2.914 1.00 30.56 ? 292 TRP A C 1 ATOM 2334 O O . TRP A 1 292 ? 15.142 62.072 -1.734 1.00 31.07 ? 292 TRP A O 1 ATOM 2335 C CB . TRP A 1 292 ? 13.629 63.124 -4.176 1.00 30.79 ? 292 TRP A CB 1 ATOM 2336 C CG . TRP A 1 292 ? 14.477 64.346 -4.359 1.00 31.04 ? 292 TRP A CG 1 ATOM 2337 C CD1 . TRP A 1 292 ? 15.611 64.453 -5.106 1.00 31.52 ? 292 TRP A CD1 1 ATOM 2338 C CD2 . TRP A 1 292 ? 14.223 65.648 -3.824 1.00 30.44 ? 292 TRP A CD2 1 ATOM 2339 N NE1 . TRP A 1 292 ? 16.081 65.746 -5.074 1.00 32.36 ? 292 TRP A NE1 1 ATOM 2340 C CE2 . TRP A 1 292 ? 15.246 66.502 -4.292 1.00 30.73 ? 292 TRP A CE2 1 ATOM 2341 C CE3 . TRP A 1 292 ? 13.227 66.178 -2.993 1.00 29.64 ? 292 TRP A CE3 1 ATOM 2342 C CZ2 . TRP A 1 292 ? 15.305 67.855 -3.964 1.00 29.95 ? 292 TRP A CZ2 1 ATOM 2343 C CZ3 . TRP A 1 292 ? 13.286 67.526 -2.664 1.00 31.28 ? 292 TRP A CZ3 1 ATOM 2344 C CH2 . TRP A 1 292 ? 14.321 68.349 -3.150 1.00 30.21 ? 292 TRP A CH2 1 ATOM 2345 N N . VAL A 1 293 ? 16.735 62.165 -3.316 1.00 29.76 ? 293 VAL A N 1 ATOM 2346 C CA . VAL A 1 293 ? 17.814 62.408 -2.363 1.00 30.04 ? 293 VAL A CA 1 ATOM 2347 C C . VAL A 1 293 ? 18.381 63.769 -2.748 1.00 30.45 ? 293 VAL A C 1 ATOM 2348 O O . VAL A 1 293 ? 19.185 63.878 -3.671 1.00 30.67 ? 293 VAL A O 1 ATOM 2349 C CB . VAL A 1 293 ? 18.929 61.338 -2.452 1.00 29.41 ? 293 VAL A CB 1 ATOM 2350 C CG1 . VAL A 1 293 ? 19.963 61.584 -1.365 1.00 28.34 ? 293 VAL A CG1 1 ATOM 2351 C CG2 . VAL A 1 293 ? 18.333 59.952 -2.308 1.00 27.59 ? 293 VAL A CG2 1 ATOM 2352 N N . PRO A 1 294 ? 17.956 64.830 -2.045 1.00 30.60 ? 294 PRO A N 1 ATOM 2353 C CA . PRO A 1 294 ? 18.397 66.203 -2.302 1.00 31.10 ? 294 PRO A CA 1 ATOM 2354 C C . PRO A 1 294 ? 19.896 66.413 -2.170 1.00 32.83 ? 294 PRO A C 1 ATOM 2355 O O . PRO A 1 294 ? 20.569 65.638 -1.498 1.00 34.45 ? 294 PRO A O 1 ATOM 2356 C CB . PRO A 1 294 ? 17.616 67.006 -1.269 1.00 29.10 ? 294 PRO A CB 1 ATOM 2357 C CG . PRO A 1 294 ? 16.404 66.162 -1.017 1.00 28.31 ? 294 PRO A CG 1 ATOM 2358 C CD . PRO A 1 294 ? 17.002 64.802 -0.926 1.00 29.21 ? 294 PRO A CD 1 ATOM 2359 N N . GLU A 1 295 ? 20.421 67.451 -2.819 1.00 33.72 ? 295 GLU A N 1 ATOM 2360 C CA . GLU A 1 295 ? 21.847 67.760 -2.724 1.00 35.37 ? 295 GLU A CA 1 ATOM 2361 C C . GLU A 1 295 ? 22.081 68.323 -1.327 1.00 37.17 ? 295 GLU A C 1 ATOM 2362 O O . GLU A 1 295 ? 21.151 68.851 -0.723 1.00 38.54 ? 295 GLU A O 1 ATOM 2363 C CB . GLU A 1 295 ? 22.227 68.824 -3.742 1.00 34.89 ? 295 GLU A CB 1 ATOM 2364 C CG . GLU A 1 295 ? 22.027 68.402 -5.159 1.00 37.92 ? 295 GLU A CG 1 ATOM 2365 C CD . GLU A 1 295 ? 22.978 67.302 -5.552 1.00 41.02 ? 295 GLU A CD 1 ATOM 2366 O OE1 . GLU A 1 295 ? 24.203 67.553 -5.586 1.00 41.80 ? 295 GLU A OE1 1 ATOM 2367 O OE2 . GLU A 1 295 ? 22.502 66.180 -5.820 1.00 43.63 ? 295 GLU A OE2 1 ATOM 2368 N N . THR A 1 296 ? 23.293 68.201 -0.791 1.00 38.12 ? 296 THR A N 1 ATOM 2369 C CA . THR A 1 296 ? 23.550 68.771 0.525 1.00 39.42 ? 296 THR A CA 1 ATOM 2370 C C . THR A 1 296 ? 24.650 69.809 0.446 1.00 40.47 ? 296 THR A C 1 ATOM 2371 O O . THR A 1 296 ? 25.132 70.286 1.469 1.00 41.05 ? 296 THR A O 1 ATOM 2372 C CB . THR A 1 296 ? 23.911 67.709 1.603 1.00 40.04 ? 296 THR A CB 1 ATOM 2373 O OG1 . THR A 1 296 ? 24.972 66.866 1.137 1.00 42.12 ? 296 THR A OG1 1 ATOM 2374 C CG2 . THR A 1 296 ? 22.687 66.876 1.953 1.00 39.32 ? 296 THR A CG2 1 ATOM 2375 N N . ASP A 1 297 ? 25.051 70.162 -0.770 1.00 41.62 ? 297 ASP A N 1 ATOM 2376 C CA . ASP A 1 297 ? 26.067 71.191 -0.932 1.00 43.30 ? 297 ASP A CA 1 ATOM 2377 C C . ASP A 1 297 ? 25.355 72.540 -1.159 1.00 44.60 ? 297 ASP A C 1 ATOM 2378 O O . ASP A 1 297 ? 24.141 72.639 -0.959 1.00 44.48 ? 297 ASP A O 1 ATOM 2379 C CB . ASP A 1 297 ? 27.027 70.838 -2.080 1.00 42.32 ? 297 ASP A CB 1 ATOM 2380 C CG . ASP A 1 297 ? 26.337 70.726 -3.424 1.00 43.08 ? 297 ASP A CG 1 ATOM 2381 O OD1 . ASP A 1 297 ? 25.087 70.811 -3.477 1.00 42.03 ? 297 ASP A OD1 1 ATOM 2382 O OD2 . ASP A 1 297 ? 27.061 70.549 -4.434 1.00 41.42 ? 297 ASP A OD2 1 ATOM 2383 N N . SER A 1 298 ? 26.089 73.576 -1.554 1.00 45.34 ? 298 SER A N 1 ATOM 2384 C CA . SER A 1 298 ? 25.475 74.889 -1.752 1.00 45.91 ? 298 SER A CA 1 ATOM 2385 C C . SER A 1 298 ? 24.775 75.001 -3.099 1.00 45.80 ? 298 SER A C 1 ATOM 2386 O O . SER A 1 298 ? 25.075 74.244 -4.021 1.00 45.44 ? 298 SER A O 1 ATOM 2387 C CB . SER A 1 298 ? 26.529 75.984 -1.662 1.00 46.34 ? 298 SER A CB 1 ATOM 2388 O OG . SER A 1 298 ? 27.216 76.088 -2.895 1.00 47.09 ? 298 SER A OG 1 ATOM 2389 N N . GLN A 1 299 ? 23.852 75.955 -3.217 1.00 45.23 ? 299 GLN A N 1 ATOM 2390 C CA . GLN A 1 299 ? 23.143 76.142 -4.476 1.00 44.80 ? 299 GLN A CA 1 ATOM 2391 C C . GLN A 1 299 ? 24.110 76.628 -5.535 1.00 44.13 ? 299 GLN A C 1 ATOM 2392 O O . GLN A 1 299 ? 23.947 76.348 -6.723 1.00 43.35 ? 299 GLN A O 1 ATOM 2393 C CB . GLN A 1 299 ? 22.026 77.165 -4.343 1.00 45.28 ? 299 GLN A CB 1 ATOM 2394 C CG . GLN A 1 299 ? 21.267 77.333 -5.648 1.00 47.34 ? 299 GLN A CG 1 ATOM 2395 C CD . GLN A 1 299 ? 20.343 78.518 -5.638 1.00 47.77 ? 299 GLN A CD 1 ATOM 2396 O OE1 . GLN A 1 299 ? 19.493 78.643 -4.763 1.00 49.01 ? 299 GLN A OE1 1 ATOM 2397 N NE2 . GLN A 1 299 ? 20.503 79.399 -6.616 1.00 47.93 ? 299 GLN A NE2 1 ATOM 2398 N N . ALA A 1 300 ? 25.107 77.382 -5.087 1.00 44.27 ? 300 ALA A N 1 ATOM 2399 C CA . ALA A 1 300 ? 26.128 77.908 -5.973 1.00 43.76 ? 300 ALA A CA 1 ATOM 2400 C C . ALA A 1 300 ? 26.818 76.698 -6.570 1.00 44.01 ? 300 ALA A C 1 ATOM 2401 O O . ALA A 1 300 ? 27.107 76.650 -7.765 1.00 44.02 ? 300 ALA A O 1 ATOM 2402 C CB . ALA A 1 300 ? 27.110 78.732 -5.185 1.00 43.32 ? 300 ALA A CB 1 ATOM 2403 N N . ASP A 1 301 ? 27.068 75.714 -5.714 1.00 44.20 ? 301 ASP A N 1 ATOM 2404 C CA . ASP A 1 301 ? 27.706 74.476 -6.125 1.00 44.16 ? 301 ASP A CA 1 ATOM 2405 C C . ASP A 1 301 ? 26.877 73.791 -7.202 1.00 43.64 ? 301 ASP A C 1 ATOM 2406 O O . ASP A 1 301 ? 27.409 73.357 -8.215 1.00 42.10 ? 301 ASP A O 1 ATOM 2407 C CB . ASP A 1 301 ? 27.859 73.552 -4.917 1.00 46.12 ? 301 ASP A CB 1 ATOM 2408 C CG . ASP A 1 301 ? 28.986 73.980 -3.993 1.00 48.36 ? 301 ASP A CG 1 ATOM 2409 O OD1 . ASP A 1 301 ? 28.930 73.663 -2.779 1.00 47.47 ? 301 ASP A OD1 1 ATOM 2410 O OD2 . ASP A 1 301 ? 29.936 74.625 -4.489 1.00 49.98 ? 301 ASP A OD2 1 ATOM 2411 N N . ASP A 1 302 ? 25.569 73.705 -6.976 1.00 44.61 ? 302 ASP A N 1 ATOM 2412 C CA . ASP A 1 302 ? 24.663 73.071 -7.927 1.00 45.80 ? 302 ASP A CA 1 ATOM 2413 C C . ASP A 1 302 ? 24.768 73.716 -9.302 1.00 46.01 ? 302 ASP A C 1 ATOM 2414 O O . ASP A 1 302 ? 24.954 73.036 -10.314 1.00 44.77 ? 302 ASP A O 1 ATOM 2415 C CB . ASP A 1 302 ? 23.224 73.174 -7.425 1.00 47.14 ? 302 ASP A CB 1 ATOM 2416 C CG . ASP A 1 302 ? 22.997 72.400 -6.143 1.00 48.88 ? 302 ASP A CG 1 ATOM 2417 O OD1 . ASP A 1 302 ? 21.900 72.544 -5.558 1.00 50.60 ? 302 ASP A OD1 1 ATOM 2418 O OD2 . ASP A 1 302 ? 23.903 71.647 -5.721 1.00 48.09 ? 302 ASP A OD2 1 ATOM 2419 N N . ILE A 1 303 ? 24.639 75.035 -9.331 1.00 46.96 ? 303 ILE A N 1 ATOM 2420 C CA . ILE A 1 303 ? 24.731 75.783 -10.577 1.00 48.30 ? 303 ILE A CA 1 ATOM 2421 C C . ILE A 1 303 ? 26.068 75.473 -11.218 1.00 48.77 ? 303 ILE A C 1 ATOM 2422 O O . ILE A 1 303 ? 26.162 75.231 -12.419 1.00 48.60 ? 303 ILE A O 1 ATOM 2423 C CB . ILE A 1 303 ? 24.692 77.289 -10.324 1.00 48.80 ? 303 ILE A CB 1 ATOM 2424 C CG1 . ILE A 1 303 ? 23.473 77.648 -9.469 1.00 48.77 ? 303 ILE A CG1 1 ATOM 2425 C CG2 . ILE A 1 303 ? 24.687 78.017 -11.647 1.00 47.86 ? 303 ILE A CG2 1 ATOM 2426 C CD1 . ILE A 1 303 ? 22.149 77.385 -10.148 1.00 50.89 ? 303 ILE A CD1 1 ATOM 2427 N N . GLU A 1 304 ? 27.103 75.492 -10.388 1.00 49.58 ? 304 GLU A N 1 ATOM 2428 C CA . GLU A 1 304 ? 28.453 75.222 -10.834 1.00 50.68 ? 304 GLU A CA 1 ATOM 2429 C C . GLU A 1 304 ? 28.582 73.886 -11.563 1.00 49.92 ? 304 GLU A C 1 ATOM 2430 O O . GLU A 1 304 ? 28.905 73.863 -12.753 1.00 49.76 ? 304 GLU A O 1 ATOM 2431 C CB . GLU A 1 304 ? 29.403 75.259 -9.640 1.00 54.62 ? 304 GLU A CB 1 ATOM 2432 C CG . GLU A 1 304 ? 30.839 74.993 -10.021 1.00 61.64 ? 304 GLU A CG 1 ATOM 2433 C CD . GLU A 1 304 ? 31.365 75.998 -11.030 1.00 65.81 ? 304 GLU A CD 1 ATOM 2434 O OE1 . GLU A 1 304 ? 32.337 75.670 -11.750 1.00 68.78 ? 304 GLU A OE1 1 ATOM 2435 O OE2 . GLU A 1 304 ? 30.813 77.120 -11.093 1.00 68.06 ? 304 GLU A OE2 1 ATOM 2436 N N . LYS A 1 305 ? 28.324 72.781 -10.858 1.00 48.93 ? 305 LYS A N 1 ATOM 2437 C CA . LYS A 1 305 ? 28.432 71.452 -11.459 1.00 47.41 ? 305 LYS A CA 1 ATOM 2438 C C . LYS A 1 305 ? 27.353 71.195 -12.505 1.00 47.44 ? 305 LYS A C 1 ATOM 2439 O O . LYS A 1 305 ? 27.431 70.234 -13.276 1.00 46.89 ? 305 LYS A O 1 ATOM 2440 C CB . LYS A 1 305 ? 28.423 70.351 -10.382 1.00 46.04 ? 305 LYS A CB 1 ATOM 2441 C CG . LYS A 1 305 ? 27.144 70.180 -9.571 1.00 44.42 ? 305 LYS A CG 1 ATOM 2442 C CD . LYS A 1 305 ? 27.334 69.018 -8.585 1.00 42.65 ? 305 LYS A CD 1 ATOM 2443 C CE . LYS A 1 305 ? 26.061 68.643 -7.823 1.00 41.45 ? 305 LYS A CE 1 ATOM 2444 N NZ . LYS A 1 305 ? 25.681 69.622 -6.766 1.00 40.37 ? 305 LYS A NZ 1 ATOM 2445 N N . GLY A 1 306 ? 26.343 72.059 -12.522 1.00 47.06 ? 306 GLY A N 1 ATOM 2446 C CA . GLY A 1 306 ? 25.291 71.948 -13.515 1.00 47.36 ? 306 GLY A CA 1 ATOM 2447 C C . GLY A 1 306 ? 24.111 71.031 -13.273 1.00 47.48 ? 306 GLY A C 1 ATOM 2448 O O . GLY A 1 306 ? 23.304 70.827 -14.184 1.00 48.71 ? 306 GLY A O 1 ATOM 2449 N N . TRP A 1 307 ? 23.995 70.475 -12.073 1.00 46.85 ? 307 TRP A N 1 ATOM 2450 C CA . TRP A 1 307 ? 22.879 69.588 -11.766 1.00 45.06 ? 307 TRP A CA 1 ATOM 2451 C C . TRP A 1 307 ? 22.615 69.505 -10.269 1.00 45.07 ? 307 TRP A C 1 ATOM 2452 O O . TRP A 1 307 ? 23.459 69.880 -9.449 1.00 45.93 ? 307 TRP A O 1 ATOM 2453 C CB . TRP A 1 307 ? 23.134 68.173 -12.312 1.00 43.33 ? 307 TRP A CB 1 ATOM 2454 C CG . TRP A 1 307 ? 24.375 67.531 -11.772 1.00 41.13 ? 307 TRP A CG 1 ATOM 2455 C CD1 . TRP A 1 307 ? 25.647 67.736 -12.199 1.00 40.87 ? 307 TRP A CD1 1 ATOM 2456 C CD2 . TRP A 1 307 ? 24.463 66.635 -10.660 1.00 41.46 ? 307 TRP A CD2 1 ATOM 2457 N NE1 . TRP A 1 307 ? 26.530 67.025 -11.426 1.00 41.13 ? 307 TRP A NE1 1 ATOM 2458 C CE2 . TRP A 1 307 ? 25.827 66.335 -10.472 1.00 41.67 ? 307 TRP A CE2 1 ATOM 2459 C CE3 . TRP A 1 307 ? 23.519 66.050 -9.804 1.00 41.38 ? 307 TRP A CE3 1 ATOM 2460 C CZ2 . TRP A 1 307 ? 26.277 65.486 -9.455 1.00 41.61 ? 307 TRP A CZ2 1 ATOM 2461 C CZ3 . TRP A 1 307 ? 23.964 65.203 -8.792 1.00 41.58 ? 307 TRP A CZ3 1 ATOM 2462 C CH2 . TRP A 1 307 ? 25.331 64.928 -8.630 1.00 42.43 ? 307 TRP A CH2 1 ATOM 2463 N N . ALA A 1 308 ? 21.434 69.009 -9.920 1.00 43.71 ? 308 ALA A N 1 ATOM 2464 C CA . ALA A 1 308 ? 21.052 68.862 -8.526 1.00 42.44 ? 308 ALA A CA 1 ATOM 2465 C C . ALA A 1 308 ? 19.957 67.811 -8.409 1.00 41.05 ? 308 ALA A C 1 ATOM 2466 O O . ALA A 1 308 ? 19.045 67.748 -9.237 1.00 41.39 ? 308 ALA A O 1 ATOM 2467 C CB . ALA A 1 308 ? 20.572 70.198 -7.976 1.00 42.21 ? 308 ALA A CB 1 ATOM 2468 N N . GLY A 1 309 ? 20.068 66.977 -7.383 1.00 38.92 ? 309 GLY A N 1 ATOM 2469 C CA . GLY A 1 309 ? 19.084 65.941 -7.164 1.00 36.23 ? 309 GLY A CA 1 ATOM 2470 C C . GLY A 1 309 ? 19.489 64.577 -7.684 1.00 34.76 ? 309 GLY A C 1 ATOM 2471 O O . GLY A 1 309 ? 20.074 64.448 -8.761 1.00 34.84 ? 309 GLY A O 1 ATOM 2472 N N . LEU A 1 310 ? 19.169 63.557 -6.896 1.00 33.26 ? 310 LEU A N 1 ATOM 2473 C CA . LEU A 1 310 ? 19.448 62.170 -7.234 1.00 31.92 ? 310 LEU A CA 1 ATOM 2474 C C . LEU A 1 310 ? 18.253 61.342 -6.787 1.00 31.88 ? 310 LEU A C 1 ATOM 2475 O O . LEU A 1 310 ? 17.396 61.826 -6.045 1.00 31.98 ? 310 LEU A O 1 ATOM 2476 C CB . LEU A 1 310 ? 20.684 61.669 -6.495 1.00 30.57 ? 310 LEU A CB 1 ATOM 2477 C CG . LEU A 1 310 ? 22.062 62.235 -6.827 1.00 31.40 ? 310 LEU A CG 1 ATOM 2478 C CD1 . LEU A 1 310 ? 23.076 61.540 -5.928 1.00 30.67 ? 310 LEU A CD1 1 ATOM 2479 C CD2 . LEU A 1 310 ? 22.410 62.014 -8.299 1.00 30.46 ? 310 LEU A CD2 1 ATOM 2480 N N . GLN A 1 311 ? 18.190 60.100 -7.248 1.00 31.41 ? 311 GLN A N 1 ATOM 2481 C CA . GLN A 1 311 ? 17.117 59.195 -6.851 1.00 32.12 ? 311 GLN A CA 1 ATOM 2482 C C . GLN A 1 311 ? 17.782 58.027 -6.128 1.00 32.39 ? 311 GLN A C 1 ATOM 2483 O O . GLN A 1 311 ? 18.755 57.466 -6.625 1.00 32.40 ? 311 GLN A O 1 ATOM 2484 C CB . GLN A 1 311 ? 16.359 58.656 -8.072 1.00 32.40 ? 311 GLN A CB 1 ATOM 2485 C CG . GLN A 1 311 ? 15.499 59.660 -8.814 1.00 33.82 ? 311 GLN A CG 1 ATOM 2486 C CD . GLN A 1 311 ? 14.346 60.155 -7.979 1.00 33.87 ? 311 GLN A CD 1 ATOM 2487 O OE1 . GLN A 1 311 ? 13.647 59.369 -7.350 1.00 33.33 ? 311 GLN A OE1 1 ATOM 2488 N NE2 . GLN A 1 311 ? 14.131 61.464 -7.976 1.00 34.71 ? 311 GLN A NE2 1 ATOM 2489 N N . SER A 1 312 ? 17.282 57.676 -4.950 1.00 32.42 ? 312 SER A N 1 ATOM 2490 C CA . SER A 1 312 ? 17.829 56.549 -4.205 1.00 33.23 ? 312 SER A CA 1 ATOM 2491 C C . SER A 1 312 ? 17.686 55.335 -5.114 1.00 35.45 ? 312 SER A C 1 ATOM 2492 O O . SER A 1 312 ? 16.764 55.282 -5.925 1.00 36.84 ? 312 SER A O 1 ATOM 2493 C CB . SER A 1 312 ? 17.005 56.321 -2.948 1.00 32.48 ? 312 SER A CB 1 ATOM 2494 O OG . SER A 1 312 ? 15.636 56.163 -3.291 1.00 30.27 ? 312 SER A OG 1 ATOM 2495 N N . PHE A 1 313 ? 18.576 54.357 -5.005 1.00 36.27 ? 313 PHE A N 1 ATOM 2496 C CA . PHE A 1 313 ? 18.429 53.187 -5.857 1.00 36.83 ? 313 PHE A CA 1 ATOM 2497 C C . PHE A 1 313 ? 17.107 52.498 -5.509 1.00 37.19 ? 313 PHE A C 1 ATOM 2498 O O . PHE A 1 313 ? 16.794 52.297 -4.333 1.00 37.98 ? 313 PHE A O 1 ATOM 2499 C CB . PHE A 1 313 ? 19.578 52.214 -5.644 1.00 38.24 ? 313 PHE A CB 1 ATOM 2500 C CG . PHE A 1 313 ? 19.684 51.184 -6.722 1.00 39.94 ? 313 PHE A CG 1 ATOM 2501 C CD1 . PHE A 1 313 ? 20.209 51.517 -7.969 1.00 39.92 ? 313 PHE A CD1 1 ATOM 2502 C CD2 . PHE A 1 313 ? 19.207 49.894 -6.516 1.00 40.18 ? 313 PHE A CD2 1 ATOM 2503 C CE1 . PHE A 1 313 ? 20.257 50.578 -8.995 1.00 40.53 ? 313 PHE A CE1 1 ATOM 2504 C CE2 . PHE A 1 313 ? 19.251 48.945 -7.536 1.00 39.95 ? 313 PHE A CE2 1 ATOM 2505 C CZ . PHE A 1 313 ? 19.775 49.288 -8.778 1.00 40.51 ? 313 PHE A CZ 1 ATOM 2506 N N . PRO A 1 314 ? 16.318 52.118 -6.525 1.00 36.30 ? 314 PRO A N 1 ATOM 2507 C CA . PRO A 1 314 ? 15.033 51.459 -6.286 1.00 36.93 ? 314 PRO A CA 1 ATOM 2508 C C . PRO A 1 314 ? 15.152 50.332 -5.281 1.00 38.07 ? 314 PRO A C 1 ATOM 2509 O O . PRO A 1 314 ? 16.009 49.459 -5.438 1.00 40.16 ? 314 PRO A O 1 ATOM 2510 C CB . PRO A 1 314 ? 14.654 50.932 -7.665 1.00 35.43 ? 314 PRO A CB 1 ATOM 2511 C CG . PRO A 1 314 ? 15.269 51.910 -8.571 1.00 36.26 ? 314 PRO A CG 1 ATOM 2512 C CD . PRO A 1 314 ? 16.631 52.123 -7.959 1.00 36.07 ? 314 PRO A CD 1 ATOM 2513 N N . ARG A 1 315 ? 14.318 50.342 -4.243 1.00 37.71 ? 315 ARG A N 1 ATOM 2514 C CA . ARG A 1 315 ? 14.371 49.250 -3.275 1.00 36.76 ? 315 ARG A CA 1 ATOM 2515 C C . ARG A 1 315 ? 13.058 48.514 -3.030 1.00 35.30 ? 315 ARG A C 1 ATOM 2516 O O . ARG A 1 315 ? 11.974 49.106 -3.040 1.00 33.91 ? 315 ARG A O 1 ATOM 2517 C CB . ARG A 1 315 ? 14.995 49.706 -1.935 1.00 36.31 ? 315 ARG A CB 1 ATOM 2518 C CG . ARG A 1 315 ? 14.750 51.134 -1.484 1.00 35.83 ? 315 ARG A CG 1 ATOM 2519 C CD . ARG A 1 315 ? 16.028 51.682 -0.822 1.00 35.16 ? 315 ARG A CD 1 ATOM 2520 N NE . ARG A 1 315 ? 15.756 52.631 0.258 1.00 36.10 ? 315 ARG A NE 1 ATOM 2521 C CZ . ARG A 1 315 ? 16.677 53.377 0.867 1.00 35.81 ? 315 ARG A CZ 1 ATOM 2522 N NH1 . ARG A 1 315 ? 17.955 53.309 0.512 1.00 33.28 ? 315 ARG A NH1 1 ATOM 2523 N NH2 . ARG A 1 315 ? 16.319 54.182 1.852 1.00 36.54 ? 315 ARG A NH2 1 ATOM 2524 N N . ALA A 1 316 ? 13.186 47.200 -2.851 1.00 33.81 ? 316 ALA A N 1 ATOM 2525 C CA . ALA A 1 316 ? 12.065 46.316 -2.575 1.00 31.53 ? 316 ALA A CA 1 ATOM 2526 C C . ALA A 1 316 ? 11.589 46.630 -1.165 1.00 31.99 ? 316 ALA A C 1 ATOM 2527 O O . ALA A 1 316 ? 12.379 47.007 -0.296 1.00 30.61 ? 316 ALA A O 1 ATOM 2528 C CB . ALA A 1 316 ? 12.506 44.879 -2.669 1.00 29.90 ? 316 ALA A CB 1 ATOM 2529 N N . LEU A 1 317 ? 10.300 46.436 -0.939 1.00 32.64 ? 317 LEU A N 1 ATOM 2530 C CA . LEU A 1 317 ? 9.693 46.766 0.330 1.00 33.44 ? 317 LEU A CA 1 ATOM 2531 C C . LEU A 1 317 ? 8.737 45.690 0.838 1.00 35.20 ? 317 LEU A C 1 ATOM 2532 O O . LEU A 1 317 ? 7.980 45.115 0.062 1.00 37.67 ? 317 LEU A O 1 ATOM 2533 C CB . LEU A 1 317 ? 8.954 48.082 0.127 1.00 32.26 ? 317 LEU A CB 1 ATOM 2534 C CG . LEU A 1 317 ? 8.071 48.668 1.206 1.00 33.99 ? 317 LEU A CG 1 ATOM 2535 C CD1 . LEU A 1 317 ? 8.907 48.919 2.444 1.00 36.95 ? 317 LEU A CD1 1 ATOM 2536 C CD2 . LEU A 1 317 ? 7.465 49.955 0.687 1.00 34.93 ? 317 LEU A CD2 1 ATOM 2537 N N . TRP A 1 318 ? 8.779 45.413 2.136 1.00 35.65 ? 318 TRP A N 1 ATOM 2538 C CA . TRP A 1 318 ? 7.889 44.427 2.734 1.00 38.07 ? 318 TRP A CA 1 ATOM 2539 C C . TRP A 1 318 ? 7.869 44.586 4.253 1.00 40.81 ? 318 TRP A C 1 ATOM 2540 O O . TRP A 1 318 ? 8.767 45.191 4.835 1.00 40.57 ? 318 TRP A O 1 ATOM 2541 C CB . TRP A 1 318 ? 8.295 42.999 2.326 1.00 37.90 ? 318 TRP A CB 1 ATOM 2542 C CG . TRP A 1 318 ? 9.622 42.541 2.842 1.00 39.19 ? 318 TRP A CG 1 ATOM 2543 C CD1 . TRP A 1 318 ? 9.878 41.975 4.055 1.00 39.10 ? 318 TRP A CD1 1 ATOM 2544 C CD2 . TRP A 1 318 ? 10.883 42.639 2.172 1.00 39.26 ? 318 TRP A CD2 1 ATOM 2545 N NE1 . TRP A 1 318 ? 11.221 41.715 4.183 1.00 38.58 ? 318 TRP A NE1 1 ATOM 2546 C CE2 . TRP A 1 318 ? 11.861 42.115 3.039 1.00 38.91 ? 318 TRP A CE2 1 ATOM 2547 C CE3 . TRP A 1 318 ? 11.282 43.124 0.921 1.00 40.19 ? 318 TRP A CE3 1 ATOM 2548 C CZ2 . TRP A 1 318 ? 13.214 42.061 2.698 1.00 39.65 ? 318 TRP A CZ2 1 ATOM 2549 C CZ3 . TRP A 1 318 ? 12.635 43.071 0.578 1.00 41.18 ? 318 TRP A CZ3 1 ATOM 2550 C CH2 . TRP A 1 318 ? 13.581 42.544 1.465 1.00 40.81 ? 318 TRP A CH2 1 ATOM 2551 N N . ILE A 1 319 ? 6.830 44.057 4.892 1.00 44.03 ? 319 ILE A N 1 ATOM 2552 C CA . ILE A 1 319 ? 6.686 44.164 6.341 1.00 45.98 ? 319 ILE A CA 1 ATOM 2553 C C . ILE A 1 319 ? 7.611 43.170 7.040 1.00 48.02 ? 319 ILE A C 1 ATOM 2554 O O . ILE A 1 319 ? 7.848 42.076 6.536 1.00 48.11 ? 319 ILE A O 1 ATOM 2555 C CB . ILE A 1 319 ? 5.215 43.907 6.755 1.00 44.76 ? 319 ILE A CB 1 ATOM 2556 C CG1 . ILE A 1 319 ? 5.004 44.252 8.223 1.00 43.72 ? 319 ILE A CG1 1 ATOM 2557 C CG2 . ILE A 1 319 ? 4.854 42.456 6.519 1.00 44.70 ? 319 ILE A CG2 1 ATOM 2558 C CD1 . ILE A 1 319 ? 3.556 44.279 8.611 1.00 43.45 ? 319 ILE A CD1 1 ATOM 2559 N N . ASP A 1 320 ? 8.141 43.556 8.196 1.00 50.73 ? 320 ASP A N 1 ATOM 2560 C CA . ASP A 1 320 ? 9.039 42.681 8.935 1.00 54.66 ? 320 ASP A CA 1 ATOM 2561 C C . ASP A 1 320 ? 8.275 41.465 9.418 1.00 56.57 ? 320 ASP A C 1 ATOM 2562 O O . ASP A 1 320 ? 7.058 41.513 9.534 1.00 56.89 ? 320 ASP A O 1 ATOM 2563 C CB . ASP A 1 320 ? 9.641 43.420 10.125 1.00 57.13 ? 320 ASP A CB 1 ATOM 2564 C CG . ASP A 1 320 ? 10.795 42.661 10.751 1.00 60.45 ? 320 ASP A CG 1 ATOM 2565 O OD1 . ASP A 1 320 ? 11.487 41.927 10.008 1.00 62.16 ? 320 ASP A OD1 1 ATOM 2566 O OD2 . ASP A 1 320 ? 11.023 42.802 11.971 1.00 61.77 ? 320 ASP A OD2 1 ATOM 2567 N N . ARG A 1 321 ? 8.977 40.375 9.700 1.00 59.31 ? 321 ARG A N 1 ATOM 2568 C CA . ARG A 1 321 ? 8.297 39.169 10.152 1.00 63.05 ? 321 ARG A CA 1 ATOM 2569 C C . ARG A 1 321 ? 7.418 39.416 11.377 1.00 62.30 ? 321 ARG A C 1 ATOM 2570 O O . ARG A 1 321 ? 6.426 38.710 11.579 1.00 62.79 ? 321 ARG A O 1 ATOM 2571 C CB . ARG A 1 321 ? 9.297 38.037 10.450 1.00 67.54 ? 321 ARG A CB 1 ATOM 2572 C CG . ARG A 1 321 ? 10.265 38.296 11.608 1.00 75.78 ? 321 ARG A CG 1 ATOM 2573 C CD . ARG A 1 321 ? 11.491 39.122 11.177 1.00 82.04 ? 321 ARG A CD 1 ATOM 2574 N NE . ARG A 1 321 ? 12.428 39.382 12.279 1.00 85.78 ? 321 ARG A NE 1 ATOM 2575 C CZ . ARG A 1 321 ? 13.637 39.925 12.128 1.00 86.96 ? 321 ARG A CZ 1 ATOM 2576 N NH1 . ARG A 1 321 ? 14.067 40.270 10.918 1.00 87.33 ? 321 ARG A NH1 1 ATOM 2577 N NH2 . ARG A 1 321 ? 14.421 40.119 13.184 1.00 87.02 ? 321 ARG A NH2 1 ATOM 2578 N N . ASN A 1 322 ? 7.765 40.419 12.182 1.00 60.95 ? 322 ASN A N 1 ATOM 2579 C CA . ASN A 1 322 ? 6.988 40.723 13.381 1.00 59.64 ? 322 ASN A CA 1 ATOM 2580 C C . ASN A 1 322 ? 5.885 41.744 13.143 1.00 57.06 ? 322 ASN A C 1 ATOM 2581 O O . ASN A 1 322 ? 5.169 42.109 14.066 1.00 57.05 ? 322 ASN A O 1 ATOM 2582 C CB . ASN A 1 322 ? 7.898 41.222 14.498 1.00 63.01 ? 322 ASN A CB 1 ATOM 2583 C CG . ASN A 1 322 ? 8.580 42.522 14.152 1.00 66.99 ? 322 ASN A CG 1 ATOM 2584 O OD1 . ASN A 1 322 ? 7.940 43.479 13.703 1.00 66.93 ? 322 ASN A OD1 1 ATOM 2585 N ND2 . ASN A 1 322 ? 9.894 42.571 14.366 1.00 70.79 ? 322 ASN A ND2 1 ATOM 2586 N N . GLY A 1 323 ? 5.772 42.216 11.907 1.00 55.69 ? 323 GLY A N 1 ATOM 2587 C CA . GLY A 1 323 ? 4.733 43.171 11.543 1.00 52.93 ? 323 GLY A CA 1 ATOM 2588 C C . GLY A 1 323 ? 4.697 44.529 12.225 1.00 50.88 ? 323 GLY A C 1 ATOM 2589 O O . GLY A 1 323 ? 3.672 45.216 12.176 1.00 49.28 ? 323 GLY A O 1 ATOM 2590 N N . LYS A 1 324 ? 5.807 44.932 12.836 1.00 49.09 ? 324 LYS A N 1 ATOM 2591 C CA . LYS A 1 324 ? 5.859 46.208 13.533 1.00 47.06 ? 324 LYS A CA 1 ATOM 2592 C C . LYS A 1 324 ? 6.516 47.302 12.704 1.00 44.76 ? 324 LYS A C 1 ATOM 2593 O O . LYS A 1 324 ? 6.253 48.484 12.910 1.00 43.57 ? 324 LYS A O 1 ATOM 2594 C CB . LYS A 1 324 ? 6.572 46.021 14.873 1.00 49.72 ? 324 LYS A CB 1 ATOM 2595 C CG . LYS A 1 324 ? 5.756 45.169 15.858 1.00 52.36 ? 324 LYS A CG 1 ATOM 2596 C CD . LYS A 1 324 ? 6.630 44.269 16.733 1.00 55.15 ? 324 LYS A CD 1 ATOM 2597 C CE . LYS A 1 324 ? 7.465 45.064 17.729 1.00 56.65 ? 324 LYS A CE 1 ATOM 2598 N NZ . LYS A 1 324 ? 8.308 44.170 18.574 1.00 57.02 ? 324 LYS A NZ 1 ATOM 2599 N N . GLN A 1 325 ? 7.365 46.903 11.763 1.00 42.94 ? 325 GLN A N 1 ATOM 2600 C CA . GLN A 1 325 ? 8.032 47.853 10.879 1.00 41.59 ? 325 GLN A CA 1 ATOM 2601 C C . GLN A 1 325 ? 8.227 47.280 9.471 1.00 40.47 ? 325 GLN A C 1 ATOM 2602 O O . GLN A 1 325 ? 8.033 46.086 9.237 1.00 41.03 ? 325 GLN A O 1 ATOM 2603 C CB . GLN A 1 325 ? 9.393 48.278 11.443 1.00 41.96 ? 325 GLN A CB 1 ATOM 2604 C CG . GLN A 1 325 ? 10.415 47.160 11.568 1.00 43.78 ? 325 GLN A CG 1 ATOM 2605 C CD . GLN A 1 325 ? 11.843 47.676 11.610 1.00 45.20 ? 325 GLN A CD 1 ATOM 2606 O OE1 . GLN A 1 325 ? 12.323 48.258 10.643 1.00 45.14 ? 325 GLN A OE1 1 ATOM 2607 N NE2 . GLN A 1 325 ? 12.528 47.462 12.731 1.00 46.66 ? 325 GLN A NE2 1 ATOM 2608 N N . LEU A 1 326 ? 8.618 48.147 8.540 1.00 38.16 ? 326 LEU A N 1 ATOM 2609 C CA . LEU A 1 326 ? 8.854 47.779 7.144 1.00 34.63 ? 326 LEU A CA 1 ATOM 2610 C C . LEU A 1 326 ? 10.340 47.492 6.881 1.00 35.25 ? 326 LEU A C 1 ATOM 2611 O O . LEU A 1 326 ? 11.215 48.048 7.548 1.00 35.61 ? 326 LEU A O 1 ATOM 2612 C CB . LEU A 1 326 ? 8.389 48.923 6.244 1.00 30.65 ? 326 LEU A CB 1 ATOM 2613 C CG . LEU A 1 326 ? 7.037 48.852 5.531 1.00 29.22 ? 326 LEU A CG 1 ATOM 2614 C CD1 . LEU A 1 326 ? 6.023 48.050 6.314 1.00 29.12 ? 326 LEU A CD1 1 ATOM 2615 C CD2 . LEU A 1 326 ? 6.557 50.264 5.299 1.00 26.11 ? 326 LEU A CD2 1 ATOM 2616 N N . ILE A 1 327 ? 10.624 46.624 5.910 1.00 34.54 ? 327 ILE A N 1 ATOM 2617 C CA . ILE A 1 327 ? 12.006 46.282 5.543 1.00 32.29 ? 327 ILE A CA 1 ATOM 2618 C C . ILE A 1 327 ? 12.253 46.676 4.087 1.00 33.56 ? 327 ILE A C 1 ATOM 2619 O O . ILE A 1 327 ? 11.396 46.448 3.232 1.00 35.73 ? 327 ILE A O 1 ATOM 2620 C CB . ILE A 1 327 ? 12.268 44.770 5.647 1.00 29.30 ? 327 ILE A CB 1 ATOM 2621 C CG1 . ILE A 1 327 ? 11.901 44.264 7.035 1.00 26.81 ? 327 ILE A CG1 1 ATOM 2622 C CG2 . ILE A 1 327 ? 13.730 44.480 5.385 1.00 29.35 ? 327 ILE A CG2 1 ATOM 2623 C CD1 . ILE A 1 327 ? 12.731 44.864 8.125 1.00 25.78 ? 327 ILE A CD1 1 ATOM 2624 N N . GLN A 1 328 ? 13.408 47.267 3.794 1.00 32.76 ? 328 GLN A N 1 ATOM 2625 C CA . GLN A 1 328 ? 13.722 47.649 2.418 1.00 32.17 ? 328 GLN A CA 1 ATOM 2626 C C . GLN A 1 328 ? 15.064 47.059 2.024 1.00 33.23 ? 328 GLN A C 1 ATOM 2627 O O . GLN A 1 328 ? 15.952 46.898 2.865 1.00 33.65 ? 328 GLN A O 1 ATOM 2628 C CB . GLN A 1 328 ? 13.806 49.158 2.272 1.00 31.90 ? 328 GLN A CB 1 ATOM 2629 C CG . GLN A 1 328 ? 12.634 49.917 2.792 1.00 30.30 ? 328 GLN A CG 1 ATOM 2630 C CD . GLN A 1 328 ? 13.004 51.354 3.060 1.00 31.77 ? 328 GLN A CD 1 ATOM 2631 O OE1 . GLN A 1 328 ? 12.750 51.868 4.141 1.00 35.04 ? 328 GLN A OE1 1 ATOM 2632 N NE2 . GLN A 1 328 ? 13.617 52.009 2.081 1.00 29.28 ? 328 GLN A NE2 1 ATOM 2633 N N . TRP A 1 329 ? 15.221 46.766 0.738 1.00 33.61 ? 329 TRP A N 1 ATOM 2634 C CA . TRP A 1 329 ? 16.461 46.179 0.236 1.00 33.68 ? 329 TRP A CA 1 ATOM 2635 C C . TRP A 1 329 ? 16.606 46.559 -1.241 1.00 33.02 ? 329 TRP A C 1 ATOM 2636 O O . TRP A 1 329 ? 15.630 46.564 -1.985 1.00 33.00 ? 329 TRP A O 1 ATOM 2637 C CB . TRP A 1 329 ? 16.398 44.650 0.417 1.00 34.03 ? 329 TRP A CB 1 ATOM 2638 C CG . TRP A 1 329 ? 17.736 43.952 0.421 1.00 34.63 ? 329 TRP A CG 1 ATOM 2639 C CD1 . TRP A 1 329 ? 18.201 43.084 -0.513 1.00 34.39 ? 329 TRP A CD1 1 ATOM 2640 C CD2 . TRP A 1 329 ? 18.781 44.082 1.400 1.00 36.51 ? 329 TRP A CD2 1 ATOM 2641 N NE1 . TRP A 1 329 ? 19.468 42.661 -0.188 1.00 34.04 ? 329 TRP A NE1 1 ATOM 2642 C CE2 . TRP A 1 329 ? 19.850 43.260 0.982 1.00 34.89 ? 329 TRP A CE2 1 ATOM 2643 C CE3 . TRP A 1 329 ? 18.920 44.820 2.588 1.00 36.84 ? 329 TRP A CE3 1 ATOM 2644 C CZ2 . TRP A 1 329 ? 21.041 43.149 1.707 1.00 33.19 ? 329 TRP A CZ2 1 ATOM 2645 C CZ3 . TRP A 1 329 ? 20.113 44.707 3.312 1.00 35.46 ? 329 TRP A CZ3 1 ATOM 2646 C CH2 . TRP A 1 329 ? 21.153 43.878 2.863 1.00 33.81 ? 329 TRP A CH2 1 ATOM 2647 N N . PRO A 1 330 ? 17.823 46.905 -1.685 1.00 32.98 ? 330 PRO A N 1 ATOM 2648 C CA . PRO A 1 330 ? 17.957 47.270 -3.099 1.00 33.23 ? 330 PRO A CA 1 ATOM 2649 C C . PRO A 1 330 ? 17.424 46.160 -4.005 1.00 33.87 ? 330 PRO A C 1 ATOM 2650 O O . PRO A 1 330 ? 17.692 44.987 -3.751 1.00 35.10 ? 330 PRO A O 1 ATOM 2651 C CB . PRO A 1 330 ? 19.465 47.476 -3.256 1.00 32.96 ? 330 PRO A CB 1 ATOM 2652 C CG . PRO A 1 330 ? 19.891 47.954 -1.895 1.00 32.26 ? 330 PRO A CG 1 ATOM 2653 C CD . PRO A 1 330 ? 19.113 47.030 -0.981 1.00 33.13 ? 330 PRO A CD 1 ATOM 2654 N N . VAL A 1 331 ? 16.667 46.512 -5.045 1.00 33.40 ? 331 VAL A N 1 ATOM 2655 C CA . VAL A 1 331 ? 16.149 45.491 -5.960 1.00 33.64 ? 331 VAL A CA 1 ATOM 2656 C C . VAL A 1 331 ? 17.303 44.610 -6.459 1.00 34.07 ? 331 VAL A C 1 ATOM 2657 O O . VAL A 1 331 ? 18.407 45.096 -6.707 1.00 32.88 ? 331 VAL A O 1 ATOM 2658 C CB . VAL A 1 331 ? 15.398 46.125 -7.155 1.00 32.06 ? 331 VAL A CB 1 ATOM 2659 C CG1 . VAL A 1 331 ? 14.192 46.876 -6.644 1.00 32.49 ? 331 VAL A CG1 1 ATOM 2660 C CG2 . VAL A 1 331 ? 16.297 47.062 -7.915 1.00 32.02 ? 331 VAL A CG2 1 ATOM 2661 N N . GLU A 1 332 ? 17.045 43.313 -6.593 1.00 35.60 ? 332 GLU A N 1 ATOM 2662 C CA . GLU A 1 332 ? 18.078 42.363 -7.007 1.00 37.64 ? 332 GLU A CA 1 ATOM 2663 C C . GLU A 1 332 ? 18.834 42.698 -8.286 1.00 37.38 ? 332 GLU A C 1 ATOM 2664 O O . GLU A 1 332 ? 20.016 42.359 -8.417 1.00 37.42 ? 332 GLU A O 1 ATOM 2665 C CB . GLU A 1 332 ? 17.479 40.961 -7.132 1.00 40.93 ? 332 GLU A CB 1 ATOM 2666 C CG . GLU A 1 332 ? 16.363 40.847 -8.156 1.00 48.26 ? 332 GLU A CG 1 ATOM 2667 C CD . GLU A 1 332 ? 15.660 39.495 -8.112 1.00 52.75 ? 332 GLU A CD 1 ATOM 2668 O OE1 . GLU A 1 332 ? 14.699 39.292 -8.892 1.00 55.20 ? 332 GLU A OE1 1 ATOM 2669 O OE2 . GLU A 1 332 ? 16.068 38.637 -7.295 1.00 54.99 ? 332 GLU A OE2 1 ATOM 2670 N N . GLU A 1 333 ? 18.167 43.358 -9.228 1.00 36.12 ? 333 GLU A N 1 ATOM 2671 C CA . GLU A 1 333 ? 18.814 43.690 -10.486 1.00 34.31 ? 333 GLU A CA 1 ATOM 2672 C C . GLU A 1 333 ? 20.142 44.389 -10.306 1.00 35.85 ? 333 GLU A C 1 ATOM 2673 O O . GLU A 1 333 ? 21.002 44.304 -11.180 1.00 37.60 ? 333 GLU A O 1 ATOM 2674 C CB . GLU A 1 333 ? 17.910 44.552 -11.358 1.00 31.42 ? 333 GLU A CB 1 ATOM 2675 C CG . GLU A 1 333 ? 16.832 43.768 -12.051 1.00 32.32 ? 333 GLU A CG 1 ATOM 2676 C CD . GLU A 1 333 ? 15.547 43.662 -11.243 1.00 34.23 ? 333 GLU A CD 1 ATOM 2677 O OE1 . GLU A 1 333 ? 15.590 43.777 -9.993 1.00 31.31 ? 333 GLU A OE1 1 ATOM 2678 O OE2 . GLU A 1 333 ? 14.486 43.449 -11.877 1.00 35.26 ? 333 GLU A OE2 1 ATOM 2679 N N . ILE A 1 334 ? 20.320 45.068 -9.176 1.00 36.41 ? 334 ILE A N 1 ATOM 2680 C CA . ILE A 1 334 ? 21.557 45.794 -8.920 1.00 37.41 ? 334 ILE A CA 1 ATOM 2681 C C . ILE A 1 334 ? 22.768 44.872 -8.942 1.00 39.10 ? 334 ILE A C 1 ATOM 2682 O O . ILE A 1 334 ? 23.867 45.269 -9.340 1.00 38.85 ? 334 ILE A O 1 ATOM 2683 C CB . ILE A 1 334 ? 21.509 46.531 -7.561 1.00 36.83 ? 334 ILE A CB 1 ATOM 2684 C CG1 . ILE A 1 334 ? 22.740 47.434 -7.424 1.00 37.78 ? 334 ILE A CG1 1 ATOM 2685 C CG2 . ILE A 1 334 ? 21.453 45.525 -6.424 1.00 36.14 ? 334 ILE A CG2 1 ATOM 2686 C CD1 . ILE A 1 334 ? 22.600 48.574 -6.417 1.00 37.36 ? 334 ILE A CD1 1 ATOM 2687 N N . GLU A 1 335 ? 22.558 43.631 -8.530 1.00 40.94 ? 335 GLU A N 1 ATOM 2688 C CA . GLU A 1 335 ? 23.633 42.664 -8.495 1.00 42.66 ? 335 GLU A CA 1 ATOM 2689 C C . GLU A 1 335 ? 24.260 42.438 -9.859 1.00 43.09 ? 335 GLU A C 1 ATOM 2690 O O . GLU A 1 335 ? 25.404 42.005 -9.957 1.00 43.67 ? 335 GLU A O 1 ATOM 2691 C CB . GLU A 1 335 ? 23.103 41.374 -7.887 1.00 44.18 ? 335 GLU A CB 1 ATOM 2692 C CG . GLU A 1 335 ? 22.821 41.562 -6.402 1.00 49.80 ? 335 GLU A CG 1 ATOM 2693 C CD . GLU A 1 335 ? 21.967 40.475 -5.794 1.00 53.44 ? 335 GLU A CD 1 ATOM 2694 O OE1 . GLU A 1 335 ? 22.239 39.285 -6.080 1.00 55.66 ? 335 GLU A OE1 1 ATOM 2695 O OE2 . GLU A 1 335 ? 21.034 40.812 -5.017 1.00 54.29 ? 335 GLU A OE2 1 ATOM 2696 N N . GLU A 1 336 ? 23.523 42.759 -10.914 1.00 44.34 ? 336 GLU A N 1 ATOM 2697 C CA . GLU A 1 336 ? 24.039 42.591 -12.265 1.00 45.72 ? 336 GLU A CA 1 ATOM 2698 C C . GLU A 1 336 ? 25.230 43.505 -12.519 1.00 43.82 ? 336 GLU A C 1 ATOM 2699 O O . GLU A 1 336 ? 26.047 43.239 -13.404 1.00 45.09 ? 336 GLU A O 1 ATOM 2700 C CB . GLU A 1 336 ? 22.946 42.879 -13.304 1.00 50.64 ? 336 GLU A CB 1 ATOM 2701 C CG . GLU A 1 336 ? 21.801 41.878 -13.281 1.00 58.49 ? 336 GLU A CG 1 ATOM 2702 C CD . GLU A 1 336 ? 22.293 40.427 -13.293 1.00 63.64 ? 336 GLU A CD 1 ATOM 2703 O OE1 . GLU A 1 336 ? 22.893 39.996 -14.308 1.00 67.09 ? 336 GLU A OE1 1 ATOM 2704 O OE2 . GLU A 1 336 ? 22.084 39.716 -12.280 1.00 65.33 ? 336 GLU A OE2 1 ATOM 2705 N N . LEU A 1 337 ? 25.331 44.576 -11.739 1.00 39.62 ? 337 LEU A N 1 ATOM 2706 C CA . LEU A 1 337 ? 26.415 45.533 -11.902 1.00 36.92 ? 337 LEU A CA 1 ATOM 2707 C C . LEU A 1 337 ? 27.682 45.116 -11.175 1.00 36.89 ? 337 LEU A C 1 ATOM 2708 O O . LEU A 1 337 ? 28.722 45.752 -11.332 1.00 37.28 ? 337 LEU A O 1 ATOM 2709 C CB . LEU A 1 337 ? 25.996 46.906 -11.381 1.00 34.49 ? 337 LEU A CB 1 ATOM 2710 C CG . LEU A 1 337 ? 24.797 47.642 -11.967 1.00 31.23 ? 337 LEU A CG 1 ATOM 2711 C CD1 . LEU A 1 337 ? 24.567 48.883 -11.125 1.00 29.47 ? 337 LEU A CD1 1 ATOM 2712 C CD2 . LEU A 1 337 ? 25.037 48.006 -13.421 1.00 28.32 ? 337 LEU A CD2 1 ATOM 2713 N N . ARG A 1 338 ? 27.595 44.065 -10.369 1.00 36.69 ? 338 ARG A N 1 ATOM 2714 C CA . ARG A 1 338 ? 28.754 43.605 -9.617 1.00 36.84 ? 338 ARG A CA 1 ATOM 2715 C C . ARG A 1 338 ? 29.833 43.037 -10.518 1.00 38.25 ? 338 ARG A C 1 ATOM 2716 O O . ARG A 1 338 ? 29.540 42.285 -11.441 1.00 39.33 ? 338 ARG A O 1 ATOM 2717 C CB . ARG A 1 338 ? 28.332 42.559 -8.598 1.00 34.80 ? 338 ARG A CB 1 ATOM 2718 C CG . ARG A 1 338 ? 27.594 43.144 -7.420 1.00 34.96 ? 338 ARG A CG 1 ATOM 2719 C CD . ARG A 1 338 ? 27.032 42.057 -6.545 1.00 34.76 ? 338 ARG A CD 1 ATOM 2720 N NE . ARG A 1 338 ? 26.390 42.593 -5.351 1.00 35.80 ? 338 ARG A NE 1 ATOM 2721 C CZ . ARG A 1 338 ? 25.713 41.846 -4.488 1.00 36.05 ? 338 ARG A CZ 1 ATOM 2722 N NH1 . ARG A 1 338 ? 25.599 40.547 -4.707 1.00 37.37 ? 338 ARG A NH1 1 ATOM 2723 N NH2 . ARG A 1 338 ? 25.162 42.387 -3.410 1.00 35.73 ? 338 ARG A NH2 1 ATOM 2724 N N . GLN A 1 339 ? 31.081 43.408 -10.243 1.00 39.68 ? 339 GLN A N 1 ATOM 2725 C CA . GLN A 1 339 ? 32.216 42.940 -11.023 1.00 41.13 ? 339 GLN A CA 1 ATOM 2726 C C . GLN A 1 339 ? 33.041 41.969 -10.189 1.00 41.66 ? 339 GLN A C 1 ATOM 2727 O O . GLN A 1 339 ? 32.586 40.867 -9.876 1.00 41.02 ? 339 GLN A O 1 ATOM 2728 C CB . GLN A 1 339 ? 33.077 44.122 -11.459 1.00 43.56 ? 339 GLN A CB 1 ATOM 2729 C CG . GLN A 1 339 ? 32.292 45.197 -12.186 1.00 50.28 ? 339 GLN A CG 1 ATOM 2730 C CD . GLN A 1 339 ? 31.608 44.672 -13.445 1.00 55.47 ? 339 GLN A CD 1 ATOM 2731 O OE1 . GLN A 1 339 ? 32.205 44.639 -14.526 1.00 59.00 ? 339 GLN A OE1 1 ATOM 2732 N NE2 . GLN A 1 339 ? 30.352 44.250 -13.307 1.00 57.41 ? 339 GLN A NE2 1 ATOM 2733 N N . ASN A 1 340 ? 34.253 42.365 -9.823 1.00 42.80 ? 340 ASN A N 1 ATOM 2734 C CA . ASN A 1 340 ? 35.092 41.491 -9.017 1.00 43.88 ? 340 ASN A CA 1 ATOM 2735 C C . ASN A 1 340 ? 34.720 41.673 -7.554 1.00 45.54 ? 340 ASN A C 1 ATOM 2736 O O . ASN A 1 340 ? 34.125 42.685 -7.170 1.00 45.90 ? 340 ASN A O 1 ATOM 2737 C CB . ASN A 1 340 ? 36.566 41.824 -9.211 1.00 42.89 ? 340 ASN A CB 1 ATOM 2738 C CG . ASN A 1 340 ? 36.966 43.092 -8.507 1.00 42.04 ? 340 ASN A CG 1 ATOM 2739 O OD1 . ASN A 1 340 ? 36.448 44.169 -8.805 1.00 40.48 ? 340 ASN A OD1 1 ATOM 2740 N ND2 . ASN A 1 340 ? 37.888 42.972 -7.553 1.00 41.92 ? 340 ASN A ND2 1 ATOM 2741 N N . GLN A 1 341 ? 35.082 40.695 -6.734 1.00 46.55 ? 341 GLN A N 1 ATOM 2742 C CA . GLN A 1 341 ? 34.761 40.745 -5.321 1.00 45.85 ? 341 GLN A CA 1 ATOM 2743 C C . GLN A 1 341 ? 35.991 40.594 -4.445 1.00 45.53 ? 341 GLN A C 1 ATOM 2744 O O . GLN A 1 341 ? 36.957 39.930 -4.817 1.00 46.81 ? 341 GLN A O 1 ATOM 2745 C CB . GLN A 1 341 ? 33.782 39.627 -4.989 1.00 46.72 ? 341 GLN A CB 1 ATOM 2746 C CG . GLN A 1 341 ? 33.222 39.705 -3.588 1.00 53.01 ? 341 GLN A CG 1 ATOM 2747 C CD . GLN A 1 341 ? 32.731 38.358 -3.085 1.00 56.28 ? 341 GLN A CD 1 ATOM 2748 O OE1 . GLN A 1 341 ? 31.962 37.669 -3.763 1.00 57.14 ? 341 GLN A OE1 1 ATOM 2749 N NE2 . GLN A 1 341 ? 33.174 37.976 -1.884 1.00 56.93 ? 341 GLN A NE2 1 ATOM 2750 N N . VAL A 1 342 ? 35.954 41.243 -3.287 1.00 45.03 ? 342 VAL A N 1 ATOM 2751 C CA . VAL A 1 342 ? 37.020 41.141 -2.301 1.00 44.07 ? 342 VAL A CA 1 ATOM 2752 C C . VAL A 1 342 ? 36.273 40.608 -1.088 1.00 44.55 ? 342 VAL A C 1 ATOM 2753 O O . VAL A 1 342 ? 35.173 41.061 -0.782 1.00 43.71 ? 342 VAL A O 1 ATOM 2754 C CB . VAL A 1 342 ? 37.642 42.491 -1.970 1.00 43.01 ? 342 VAL A CB 1 ATOM 2755 C CG1 . VAL A 1 342 ? 38.645 42.330 -0.854 1.00 41.54 ? 342 VAL A CG1 1 ATOM 2756 C CG2 . VAL A 1 342 ? 38.326 43.040 -3.188 1.00 43.62 ? 342 VAL A CG2 1 ATOM 2757 N N . ASN A 1 343 ? 36.856 39.640 -0.400 1.00 45.66 ? 343 ASN A N 1 ATOM 2758 C CA . ASN A 1 343 ? 36.165 39.042 0.718 1.00 45.84 ? 343 ASN A CA 1 ATOM 2759 C C . ASN A 1 343 ? 37.032 38.890 1.950 1.00 45.27 ? 343 ASN A C 1 ATOM 2760 O O . ASN A 1 343 ? 38.219 38.602 1.852 1.00 45.82 ? 343 ASN A O 1 ATOM 2761 C CB . ASN A 1 343 ? 35.652 37.679 0.286 1.00 49.28 ? 343 ASN A CB 1 ATOM 2762 C CG . ASN A 1 343 ? 34.414 37.285 1.012 1.00 53.49 ? 343 ASN A CG 1 ATOM 2763 O OD1 . ASN A 1 343 ? 33.371 37.920 0.858 1.00 56.25 ? 343 ASN A OD1 1 ATOM 2764 N ND2 . ASN A 1 343 ? 34.509 36.235 1.821 1.00 57.29 ? 343 ASN A ND2 1 ATOM 2765 N N . LEU A 1 344 ? 36.430 39.097 3.113 1.00 44.65 ? 344 LEU A N 1 ATOM 2766 C CA . LEU A 1 344 ? 37.134 38.959 4.384 1.00 43.36 ? 344 LEU A CA 1 ATOM 2767 C C . LEU A 1 344 ? 36.331 38.027 5.256 1.00 43.20 ? 344 LEU A C 1 ATOM 2768 O O . LEU A 1 344 ? 35.101 38.082 5.270 1.00 44.18 ? 344 LEU A O 1 ATOM 2769 C CB . LEU A 1 344 ? 37.258 40.301 5.101 1.00 41.98 ? 344 LEU A CB 1 ATOM 2770 C CG . LEU A 1 344 ? 38.199 41.319 4.474 1.00 41.80 ? 344 LEU A CG 1 ATOM 2771 C CD1 . LEU A 1 344 ? 38.225 42.580 5.318 1.00 41.96 ? 344 LEU A CD1 1 ATOM 2772 C CD2 . LEU A 1 344 ? 39.586 40.711 4.370 1.00 43.20 ? 344 LEU A CD2 1 ATOM 2773 N N . GLN A 1 345 ? 37.014 37.166 5.990 1.00 42.39 ? 345 GLN A N 1 ATOM 2774 C CA . GLN A 1 345 ? 36.302 36.260 6.860 1.00 42.87 ? 345 GLN A CA 1 ATOM 2775 C C . GLN A 1 345 ? 37.042 35.953 8.137 1.00 43.60 ? 345 GLN A C 1 ATOM 2776 O O . GLN A 1 345 ? 38.249 35.738 8.131 1.00 44.24 ? 345 GLN A O 1 ATOM 2777 C CB . GLN A 1 345 ? 35.981 34.978 6.115 1.00 43.06 ? 345 GLN A CB 1 ATOM 2778 C CG . GLN A 1 345 ? 34.640 35.046 5.449 1.00 44.36 ? 345 GLN A CG 1 ATOM 2779 C CD . GLN A 1 345 ? 34.290 33.771 4.754 1.00 45.12 ? 345 GLN A CD 1 ATOM 2780 O OE1 . GLN A 1 345 ? 34.784 33.494 3.661 1.00 46.06 ? 345 GLN A OE1 1 ATOM 2781 N NE2 . GLN A 1 345 ? 33.439 32.970 5.385 1.00 45.05 ? 345 GLN A NE2 1 ATOM 2782 N N . ASN A 1 346 ? 36.313 35.954 9.245 1.00 44.41 ? 346 ASN A N 1 ATOM 2783 C CA . ASN A 1 346 ? 36.922 35.654 10.527 1.00 45.87 ? 346 ASN A CA 1 ATOM 2784 C C . ASN A 1 346 ? 38.149 36.542 10.791 1.00 46.38 ? 346 ASN A C 1 ATOM 2785 O O . ASN A 1 346 ? 39.206 36.056 11.196 1.00 46.00 ? 346 ASN A O 1 ATOM 2786 C CB . ASN A 1 346 ? 37.320 34.184 10.537 1.00 47.01 ? 346 ASN A CB 1 ATOM 2787 C CG . ASN A 1 346 ? 37.699 33.702 11.896 1.00 49.90 ? 346 ASN A CG 1 ATOM 2788 O OD1 . ASN A 1 346 ? 36.933 33.848 12.852 1.00 53.26 ? 346 ASN A OD1 1 ATOM 2789 N ND2 . ASN A 1 346 ? 38.882 33.115 12.004 1.00 51.19 ? 346 ASN A ND2 1 ATOM 2790 N N . LYS A 1 347 ? 38.000 37.844 10.550 1.00 47.37 ? 347 LYS A N 1 ATOM 2791 C CA . LYS A 1 347 ? 39.078 38.808 10.764 1.00 48.24 ? 347 LYS A CA 1 ATOM 2792 C C . LYS A 1 347 ? 38.708 39.626 11.990 1.00 49.37 ? 347 LYS A C 1 ATOM 2793 O O . LYS A 1 347 ? 37.612 40.188 12.058 1.00 49.64 ? 347 LYS A O 1 ATOM 2794 C CB . LYS A 1 347 ? 39.228 39.740 9.555 1.00 47.39 ? 347 LYS A CB 1 ATOM 2795 C CG . LYS A 1 347 ? 40.638 40.299 9.362 1.00 47.37 ? 347 LYS A CG 1 ATOM 2796 C CD . LYS A 1 347 ? 41.108 41.089 10.572 1.00 46.75 ? 347 LYS A CD 1 ATOM 2797 C CE . LYS A 1 347 ? 42.620 41.295 10.572 1.00 46.02 ? 347 LYS A CE 1 ATOM 2798 N NZ . LYS A 1 347 ? 43.086 42.008 9.359 1.00 46.90 ? 347 LYS A NZ 1 ATOM 2799 N N . ASN A 1 348 ? 39.623 39.698 12.951 1.00 49.37 ? 348 ASN A N 1 ATOM 2800 C CA . ASN A 1 348 ? 39.360 40.425 14.177 1.00 49.82 ? 348 ASN A CA 1 ATOM 2801 C C . ASN A 1 348 ? 39.854 41.865 14.115 1.00 49.21 ? 348 ASN A C 1 ATOM 2802 O O . ASN A 1 348 ? 40.995 42.117 13.747 1.00 50.07 ? 348 ASN A O 1 ATOM 2803 C CB . ASN A 1 348 ? 40.014 39.686 15.346 1.00 52.30 ? 348 ASN A CB 1 ATOM 2804 C CG . ASN A 1 348 ? 39.479 40.134 16.696 1.00 56.68 ? 348 ASN A CG 1 ATOM 2805 O OD1 . ASN A 1 348 ? 39.786 41.231 17.177 1.00 56.83 ? 348 ASN A OD1 1 ATOM 2806 N ND2 . ASN A 1 348 ? 38.659 39.283 17.313 1.00 58.54 ? 348 ASN A ND2 1 ATOM 2807 N N . LEU A 1 349 ? 38.979 42.810 14.455 1.00 48.43 ? 349 LEU A N 1 ATOM 2808 C CA . LEU A 1 349 ? 39.334 44.228 14.473 1.00 47.86 ? 349 LEU A CA 1 ATOM 2809 C C . LEU A 1 349 ? 39.646 44.574 15.921 1.00 48.73 ? 349 LEU A C 1 ATOM 2810 O O . LEU A 1 349 ? 38.736 44.696 16.745 1.00 49.02 ? 349 LEU A O 1 ATOM 2811 C CB . LEU A 1 349 ? 38.164 45.094 14.007 1.00 46.34 ? 349 LEU A CB 1 ATOM 2812 C CG . LEU A 1 349 ? 37.750 45.101 12.542 1.00 45.09 ? 349 LEU A CG 1 ATOM 2813 C CD1 . LEU A 1 349 ? 36.442 45.848 12.389 1.00 44.63 ? 349 LEU A CD1 1 ATOM 2814 C CD2 . LEU A 1 349 ? 38.832 45.754 11.719 1.00 45.66 ? 349 LEU A CD2 1 ATOM 2815 N N . LYS A 1 350 ? 40.927 44.716 16.242 1.00 48.98 ? 350 LYS A N 1 ATOM 2816 C CA . LYS A 1 350 ? 41.297 45.038 17.609 1.00 49.00 ? 350 LYS A CA 1 ATOM 2817 C C . LYS A 1 350 ? 40.948 46.490 17.869 1.00 46.43 ? 350 LYS A C 1 ATOM 2818 O O . LYS A 1 350 ? 40.792 47.269 16.936 1.00 46.13 ? 350 LYS A O 1 ATOM 2819 C CB . LYS A 1 350 ? 42.787 44.773 17.840 1.00 52.55 ? 350 LYS A CB 1 ATOM 2820 C CG . LYS A 1 350 ? 43.709 45.417 16.828 1.00 58.56 ? 350 LYS A CG 1 ATOM 2821 C CD . LYS A 1 350 ? 45.162 45.034 17.091 1.00 62.23 ? 350 LYS A CD 1 ATOM 2822 C CE . LYS A 1 350 ? 46.119 45.899 16.281 1.00 64.17 ? 350 LYS A CE 1 ATOM 2823 N NZ . LYS A 1 350 ? 46.005 47.341 16.675 1.00 65.26 ? 350 LYS A NZ 1 ATOM 2824 N N . PRO A 1 351 ? 40.802 46.875 19.140 1.00 44.90 ? 351 PRO A N 1 ATOM 2825 C CA . PRO A 1 351 ? 40.459 48.269 19.427 1.00 44.59 ? 351 PRO A CA 1 ATOM 2826 C C . PRO A 1 351 ? 41.359 49.271 18.723 1.00 44.48 ? 351 PRO A C 1 ATOM 2827 O O . PRO A 1 351 ? 42.533 49.003 18.485 1.00 45.29 ? 351 PRO A O 1 ATOM 2828 C CB . PRO A 1 351 ? 40.560 48.337 20.942 1.00 43.91 ? 351 PRO A CB 1 ATOM 2829 C CG . PRO A 1 351 ? 40.089 46.964 21.345 1.00 43.79 ? 351 PRO A CG 1 ATOM 2830 C CD . PRO A 1 351 ? 40.844 46.077 20.376 1.00 43.58 ? 351 PRO A CD 1 ATOM 2831 N N . GLY A 1 352 ? 40.786 50.417 18.376 1.00 44.33 ? 352 GLY A N 1 ATOM 2832 C CA . GLY A 1 352 ? 41.532 51.456 17.690 1.00 44.23 ? 352 GLY A CA 1 ATOM 2833 C C . GLY A 1 352 ? 42.014 51.114 16.285 1.00 44.69 ? 352 GLY A C 1 ATOM 2834 O O . GLY A 1 352 ? 42.853 51.831 15.748 1.00 45.79 ? 352 GLY A O 1 ATOM 2835 N N . SER A 1 353 ? 41.491 50.053 15.674 1.00 44.02 ? 353 SER A N 1 ATOM 2836 C CA . SER A 1 353 ? 41.932 49.658 14.333 1.00 43.46 ? 353 SER A CA 1 ATOM 2837 C C . SER A 1 353 ? 41.289 50.375 13.156 1.00 42.45 ? 353 SER A C 1 ATOM 2838 O O . SER A 1 353 ? 40.281 51.071 13.298 1.00 43.29 ? 353 SER A O 1 ATOM 2839 C CB . SER A 1 353 ? 41.722 48.161 14.122 1.00 45.69 ? 353 SER A CB 1 ATOM 2840 O OG . SER A 1 353 ? 42.499 47.396 15.021 1.00 50.95 ? 353 SER A OG 1 ATOM 2841 N N . VAL A 1 354 ? 41.903 50.173 11.991 1.00 40.66 ? 354 VAL A N 1 ATOM 2842 C CA . VAL A 1 354 ? 41.465 50.714 10.699 1.00 38.68 ? 354 VAL A CA 1 ATOM 2843 C C . VAL A 1 354 ? 42.096 49.790 9.665 1.00 38.29 ? 354 VAL A C 1 ATOM 2844 O O . VAL A 1 354 ? 43.304 49.819 9.466 1.00 39.64 ? 354 VAL A O 1 ATOM 2845 C CB . VAL A 1 354 ? 41.981 52.154 10.438 1.00 36.41 ? 354 VAL A CB 1 ATOM 2846 C CG1 . VAL A 1 354 ? 41.699 52.550 8.999 1.00 35.31 ? 354 VAL A CG1 1 ATOM 2847 C CG2 . VAL A 1 354 ? 41.304 53.134 11.363 1.00 35.08 ? 354 VAL A CG2 1 ATOM 2848 N N . LEU A 1 355 ? 41.277 48.968 9.022 1.00 37.60 ? 355 LEU A N 1 ATOM 2849 C CA . LEU A 1 355 ? 41.739 48.006 8.023 1.00 37.70 ? 355 LEU A CA 1 ATOM 2850 C C . LEU A 1 355 ? 41.296 48.427 6.614 1.00 39.17 ? 355 LEU A C 1 ATOM 2851 O O . LEU A 1 355 ? 40.115 48.699 6.394 1.00 40.93 ? 355 LEU A O 1 ATOM 2852 C CB . LEU A 1 355 ? 41.153 46.644 8.373 1.00 35.98 ? 355 LEU A CB 1 ATOM 2853 C CG . LEU A 1 355 ? 41.322 45.482 7.411 1.00 34.99 ? 355 LEU A CG 1 ATOM 2854 C CD1 . LEU A 1 355 ? 42.693 44.924 7.577 1.00 34.73 ? 355 LEU A CD1 1 ATOM 2855 C CD2 . LEU A 1 355 ? 40.289 44.410 7.715 1.00 35.29 ? 355 LEU A CD2 1 ATOM 2856 N N . GLU A 1 356 ? 42.218 48.468 5.655 1.00 39.47 ? 356 GLU A N 1 ATOM 2857 C CA . GLU A 1 356 ? 41.843 48.894 4.306 1.00 40.75 ? 356 GLU A CA 1 ATOM 2858 C C . GLU A 1 356 ? 41.414 47.804 3.343 1.00 40.90 ? 356 GLU A C 1 ATOM 2859 O O . GLU A 1 356 ? 42.120 46.819 3.149 1.00 43.10 ? 356 GLU A O 1 ATOM 2860 C CB . GLU A 1 356 ? 42.967 49.685 3.626 1.00 40.94 ? 356 GLU A CB 1 ATOM 2861 C CG . GLU A 1 356 ? 42.498 50.304 2.304 1.00 44.16 ? 356 GLU A CG 1 ATOM 2862 C CD . GLU A 1 356 ? 43.552 51.121 1.573 1.00 46.31 ? 356 GLU A CD 1 ATOM 2863 O OE1 . GLU A 1 356 ? 44.415 51.735 2.243 1.00 46.97 ? 356 GLU A OE1 1 ATOM 2864 O OE2 . GLU A 1 356 ? 43.497 51.167 0.318 1.00 46.05 ? 356 GLU A OE2 1 ATOM 2865 N N . ILE A 1 357 ? 40.255 47.994 2.726 1.00 40.25 ? 357 ILE A N 1 ATOM 2866 C CA . ILE A 1 357 ? 39.769 47.038 1.746 1.00 40.08 ? 357 ILE A CA 1 ATOM 2867 C C . ILE A 1 357 ? 40.488 47.379 0.442 1.00 41.16 ? 357 ILE A C 1 ATOM 2868 O O . ILE A 1 357 ? 40.386 48.506 -0.056 1.00 42.39 ? 357 ILE A O 1 ATOM 2869 C CB . ILE A 1 357 ? 38.253 47.170 1.544 1.00 38.43 ? 357 ILE A CB 1 ATOM 2870 C CG1 . ILE A 1 357 ? 37.548 46.942 2.872 1.00 37.32 ? 357 ILE A CG1 1 ATOM 2871 C CG2 . ILE A 1 357 ? 37.763 46.148 0.535 1.00 38.04 ? 357 ILE A CG2 1 ATOM 2872 C CD1 . ILE A 1 357 ? 37.921 45.637 3.514 1.00 37.35 ? 357 ILE A CD1 1 ATOM 2873 N N . HIS A 1 358 ? 41.224 46.416 -0.102 1.00 39.79 ? 358 HIS A N 1 ATOM 2874 C CA . HIS A 1 358 ? 41.961 46.643 -1.335 1.00 38.22 ? 358 HIS A CA 1 ATOM 2875 C C . HIS A 1 358 ? 41.316 46.071 -2.590 1.00 38.23 ? 358 HIS A C 1 ATOM 2876 O O . HIS A 1 358 ? 40.540 45.122 -2.538 1.00 38.59 ? 358 HIS A O 1 ATOM 2877 C CB . HIS A 1 358 ? 43.364 46.065 -1.202 1.00 37.58 ? 358 HIS A CB 1 ATOM 2878 C CG . HIS A 1 358 ? 44.246 46.836 -0.277 1.00 37.45 ? 358 HIS A CG 1 ATOM 2879 N ND1 . HIS A 1 358 ? 44.868 48.007 -0.648 1.00 38.15 ? 358 HIS A ND1 1 ATOM 2880 C CD2 . HIS A 1 358 ? 44.589 46.618 1.013 1.00 38.01 ? 358 HIS A CD2 1 ATOM 2881 C CE1 . HIS A 1 358 ? 45.557 48.480 0.375 1.00 37.45 ? 358 HIS A CE1 1 ATOM 2882 N NE2 . HIS A 1 358 ? 45.403 47.656 1.395 1.00 38.23 ? 358 HIS A NE2 1 ATOM 2883 N N . GLY A 1 359 ? 41.651 46.667 -3.725 1.00 38.21 ? 359 GLY A N 1 ATOM 2884 C CA . GLY A 1 359 ? 41.144 46.180 -4.992 1.00 39.18 ? 359 GLY A CA 1 ATOM 2885 C C . GLY A 1 359 ? 39.672 46.359 -5.264 1.00 39.51 ? 359 GLY A C 1 ATOM 2886 O O . GLY A 1 359 ? 39.041 45.498 -5.877 1.00 40.64 ? 359 GLY A O 1 ATOM 2887 N N . ILE A 1 360 ? 39.121 47.480 -4.823 1.00 39.60 ? 360 ILE A N 1 ATOM 2888 C CA . ILE A 1 360 ? 37.712 47.767 -5.044 1.00 38.55 ? 360 ILE A CA 1 ATOM 2889 C C . ILE A 1 360 ? 37.568 49.184 -5.598 1.00 37.98 ? 360 ILE A C 1 ATOM 2890 O O . ILE A 1 360 ? 38.413 50.047 -5.341 1.00 39.28 ? 360 ILE A O 1 ATOM 2891 C CB . ILE A 1 360 ? 36.920 47.635 -3.714 1.00 38.04 ? 360 ILE A CB 1 ATOM 2892 C CG1 . ILE A 1 360 ? 36.759 46.157 -3.351 1.00 37.72 ? 360 ILE A CG1 1 ATOM 2893 C CG2 . ILE A 1 360 ? 35.567 48.314 -3.822 1.00 38.27 ? 360 ILE A CG2 1 ATOM 2894 C CD1 . ILE A 1 360 ? 36.023 45.342 -4.388 1.00 37.19 ? 360 ILE A CD1 1 ATOM 2895 N N . ALA A 1 361 ? 36.523 49.413 -6.384 1.00 36.28 ? 361 ALA A N 1 ATOM 2896 C CA . ALA A 1 361 ? 36.264 50.744 -6.916 1.00 36.29 ? 361 ALA A CA 1 ATOM 2897 C C . ALA A 1 361 ? 35.628 51.475 -5.738 1.00 36.77 ? 361 ALA A C 1 ATOM 2898 O O . ALA A 1 361 ? 34.430 51.724 -5.722 1.00 38.63 ? 361 ALA A O 1 ATOM 2899 C CB . ALA A 1 361 ? 35.286 50.664 -8.073 1.00 36.16 ? 361 ALA A CB 1 ATOM 2900 N N . ALA A 1 362 ? 36.447 51.794 -4.747 1.00 35.76 ? 362 ALA A N 1 ATOM 2901 C CA . ALA A 1 362 ? 36.015 52.450 -3.520 1.00 35.28 ? 362 ALA A CA 1 ATOM 2902 C C . ALA A 1 362 ? 34.963 53.545 -3.615 1.00 35.67 ? 362 ALA A C 1 ATOM 2903 O O . ALA A 1 362 ? 34.280 53.832 -2.628 1.00 35.76 ? 362 ALA A O 1 ATOM 2904 C CB . ALA A 1 362 ? 37.228 52.993 -2.790 1.00 36.33 ? 362 ALA A CB 1 ATOM 2905 N N . SER A 1 363 ? 34.828 54.170 -4.776 1.00 34.90 ? 363 SER A N 1 ATOM 2906 C CA . SER A 1 363 ? 33.852 55.242 -4.915 1.00 36.50 ? 363 SER A CA 1 ATOM 2907 C C . SER A 1 363 ? 32.566 54.772 -5.571 1.00 36.55 ? 363 SER A C 1 ATOM 2908 O O . SER A 1 363 ? 31.576 55.497 -5.639 1.00 38.09 ? 363 SER A O 1 ATOM 2909 C CB . SER A 1 363 ? 34.465 56.370 -5.721 1.00 37.54 ? 363 SER A CB 1 ATOM 2910 O OG . SER A 1 363 ? 35.276 55.820 -6.734 1.00 41.96 ? 363 SER A OG 1 ATOM 2911 N N . GLN A 1 364 ? 32.588 53.543 -6.054 1.00 35.84 ? 364 GLN A N 1 ATOM 2912 C CA . GLN A 1 364 ? 31.431 52.964 -6.703 1.00 33.62 ? 364 GLN A CA 1 ATOM 2913 C C . GLN A 1 364 ? 31.481 51.483 -6.362 1.00 33.53 ? 364 GLN A C 1 ATOM 2914 O O . GLN A 1 364 ? 32.012 50.676 -7.131 1.00 31.98 ? 364 GLN A O 1 ATOM 2915 C CB . GLN A 1 364 ? 31.538 53.187 -8.207 1.00 32.33 ? 364 GLN A CB 1 ATOM 2916 C CG . GLN A 1 364 ? 30.258 53.007 -8.954 1.00 32.10 ? 364 GLN A CG 1 ATOM 2917 C CD . GLN A 1 364 ? 30.376 53.483 -10.381 1.00 32.06 ? 364 GLN A CD 1 ATOM 2918 O OE1 . GLN A 1 364 ? 30.802 54.613 -10.636 1.00 30.37 ? 364 GLN A OE1 1 ATOM 2919 N NE2 . GLN A 1 364 ? 29.993 52.628 -11.324 1.00 30.96 ? 364 GLN A NE2 1 ATOM 2920 N N . ALA A 1 365 ? 30.954 51.137 -5.188 1.00 32.85 ? 365 ALA A N 1 ATOM 2921 C CA . ALA A 1 365 ? 30.958 49.754 -4.742 1.00 32.81 ? 365 ALA A CA 1 ATOM 2922 C C . ALA A 1 365 ? 29.729 49.354 -3.932 1.00 33.78 ? 365 ALA A C 1 ATOM 2923 O O . ALA A 1 365 ? 28.908 50.192 -3.555 1.00 34.33 ? 365 ALA A O 1 ATOM 2924 C CB . ALA A 1 365 ? 32.213 49.483 -3.940 1.00 31.85 ? 365 ALA A CB 1 ATOM 2925 N N . ASP A 1 366 ? 29.622 48.052 -3.681 1.00 34.68 ? 366 ASP A N 1 ATOM 2926 C CA . ASP A 1 366 ? 28.529 47.459 -2.921 1.00 34.77 ? 366 ASP A CA 1 ATOM 2927 C C . ASP A 1 366 ? 29.220 46.644 -1.819 1.00 35.88 ? 366 ASP A C 1 ATOM 2928 O O . ASP A 1 366 ? 29.825 45.610 -2.095 1.00 36.54 ? 366 ASP A O 1 ATOM 2929 C CB . ASP A 1 366 ? 27.708 46.568 -3.858 1.00 34.60 ? 366 ASP A CB 1 ATOM 2930 C CG . ASP A 1 366 ? 26.521 45.928 -3.179 1.00 36.56 ? 366 ASP A CG 1 ATOM 2931 O OD1 . ASP A 1 366 ? 26.113 46.394 -2.097 1.00 38.03 ? 366 ASP A OD1 1 ATOM 2932 O OD2 . ASP A 1 366 ? 25.979 44.953 -3.742 1.00 38.56 ? 366 ASP A OD2 1 ATOM 2933 N N . VAL A 1 367 ? 29.142 47.120 -0.576 1.00 36.19 ? 367 VAL A N 1 ATOM 2934 C CA . VAL A 1 367 ? 29.812 46.457 0.545 1.00 36.71 ? 367 VAL A CA 1 ATOM 2935 C C . VAL A 1 367 ? 28.895 45.868 1.621 1.00 37.23 ? 367 VAL A C 1 ATOM 2936 O O . VAL A 1 367 ? 27.987 46.542 2.105 1.00 38.01 ? 367 VAL A O 1 ATOM 2937 C CB . VAL A 1 367 ? 30.783 47.448 1.243 1.00 36.31 ? 367 VAL A CB 1 ATOM 2938 C CG1 . VAL A 1 367 ? 31.589 46.729 2.300 1.00 37.20 ? 367 VAL A CG1 1 ATOM 2939 C CG2 . VAL A 1 367 ? 31.707 48.092 0.218 1.00 36.00 ? 367 VAL A CG2 1 ATOM 2940 N N . THR A 1 368 ? 29.135 44.612 1.996 1.00 37.53 ? 368 THR A N 1 ATOM 2941 C CA . THR A 1 368 ? 28.341 43.961 3.046 1.00 38.35 ? 368 THR A CA 1 ATOM 2942 C C . THR A 1 368 ? 29.290 43.453 4.098 1.00 39.16 ? 368 THR A C 1 ATOM 2943 O O . THR A 1 368 ? 30.263 42.773 3.777 1.00 42.11 ? 368 THR A O 1 ATOM 2944 C CB . THR A 1 368 ? 27.582 42.722 2.571 1.00 37.11 ? 368 THR A CB 1 ATOM 2945 O OG1 . THR A 1 368 ? 27.232 42.870 1.196 1.00 41.59 ? 368 THR A OG1 1 ATOM 2946 C CG2 . THR A 1 368 ? 26.310 42.544 3.393 1.00 36.94 ? 368 THR A CG2 1 ATOM 2947 N N . ILE A 1 369 ? 29.003 43.765 5.354 1.00 38.41 ? 369 ILE A N 1 ATOM 2948 C CA . ILE A 1 369 ? 29.848 43.324 6.446 1.00 37.07 ? 369 ILE A CA 1 ATOM 2949 C C . ILE A 1 369 ? 28.968 42.844 7.588 1.00 37.25 ? 369 ILE A C 1 ATOM 2950 O O . ILE A 1 369 ? 27.843 43.310 7.761 1.00 36.22 ? 369 ILE A O 1 ATOM 2951 C CB . ILE A 1 369 ? 30.777 44.467 6.917 1.00 35.89 ? 369 ILE A CB 1 ATOM 2952 C CG1 . ILE A 1 369 ? 31.832 43.926 7.878 1.00 35.37 ? 369 ILE A CG1 1 ATOM 2953 C CG2 . ILE A 1 369 ? 29.966 45.560 7.579 1.00 36.12 ? 369 ILE A CG2 1 ATOM 2954 C CD1 . ILE A 1 369 ? 33.015 44.849 8.049 1.00 34.08 ? 369 ILE A CD1 1 ATOM 2955 N N . SER A 1 370 ? 29.477 41.890 8.353 1.00 38.32 ? 370 SER A N 1 ATOM 2956 C CA . SER A 1 370 ? 28.723 41.343 9.464 1.00 39.57 ? 370 SER A CA 1 ATOM 2957 C C . SER A 1 370 ? 29.659 41.148 10.654 1.00 40.76 ? 370 SER A C 1 ATOM 2958 O O . SER A 1 370 ? 30.627 40.385 10.581 1.00 41.14 ? 370 SER A O 1 ATOM 2959 C CB . SER A 1 370 ? 28.095 40.015 9.044 1.00 38.60 ? 370 SER A CB 1 ATOM 2960 O OG . SER A 1 370 ? 27.078 39.618 9.945 1.00 39.81 ? 370 SER A OG 1 ATOM 2961 N N . PHE A 1 371 ? 29.368 41.837 11.752 1.00 41.67 ? 371 PHE A N 1 ATOM 2962 C CA . PHE A 1 371 ? 30.204 41.760 12.943 1.00 43.13 ? 371 PHE A CA 1 ATOM 2963 C C . PHE A 1 371 ? 29.753 40.758 13.999 1.00 44.46 ? 371 PHE A C 1 ATOM 2964 O O . PHE A 1 371 ? 28.558 40.551 14.214 1.00 44.50 ? 371 PHE A O 1 ATOM 2965 C CB . PHE A 1 371 ? 30.288 43.139 13.589 1.00 42.95 ? 371 PHE A CB 1 ATOM 2966 C CG . PHE A 1 371 ? 30.854 44.185 12.694 1.00 43.50 ? 371 PHE A CG 1 ATOM 2967 C CD1 . PHE A 1 371 ? 32.234 44.348 12.579 1.00 43.51 ? 371 PHE A CD1 1 ATOM 2968 C CD2 . PHE A 1 371 ? 30.009 45.000 11.939 1.00 44.48 ? 371 PHE A CD2 1 ATOM 2969 C CE1 . PHE A 1 371 ? 32.770 45.311 11.712 1.00 44.66 ? 371 PHE A CE1 1 ATOM 2970 C CE2 . PHE A 1 371 ? 30.530 45.968 11.067 1.00 45.22 ? 371 PHE A CE2 1 ATOM 2971 C CZ . PHE A 1 371 ? 31.913 46.125 10.955 1.00 44.61 ? 371 PHE A CZ 1 ATOM 2972 N N . LYS A 1 372 ? 30.737 40.151 14.657 1.00 46.33 ? 372 LYS A N 1 ATOM 2973 C CA . LYS A 1 372 ? 30.515 39.195 15.738 1.00 48.03 ? 372 LYS A CA 1 ATOM 2974 C C . LYS A 1 372 ? 31.040 39.946 16.978 1.00 49.11 ? 372 LYS A C 1 ATOM 2975 O O . LYS A 1 372 ? 32.241 40.191 17.085 1.00 49.09 ? 372 LYS A O 1 ATOM 2976 C CB . LYS A 1 372 ? 31.332 37.916 15.482 1.00 47.87 ? 372 LYS A CB 1 ATOM 2977 C CG . LYS A 1 372 ? 30.625 36.608 15.850 1.00 49.16 ? 372 LYS A CG 1 ATOM 2978 C CD . LYS A 1 372 ? 31.515 35.380 15.612 1.00 52.04 ? 372 LYS A CD 1 ATOM 2979 C CE . LYS A 1 372 ? 31.846 35.167 14.126 1.00 55.16 ? 372 LYS A CE 1 ATOM 2980 N NZ . LYS A 1 372 ? 32.873 34.093 13.867 1.00 55.08 ? 372 LYS A NZ 1 ATOM 2981 N N . LEU A 1 373 ? 30.149 40.328 17.896 1.00 50.69 ? 373 LEU A N 1 ATOM 2982 C CA . LEU A 1 373 ? 30.540 41.090 19.092 1.00 52.54 ? 373 LEU A CA 1 ATOM 2983 C C . LEU A 1 373 ? 31.207 40.318 20.217 1.00 55.61 ? 373 LEU A C 1 ATOM 2984 O O . LEU A 1 373 ? 30.849 39.177 20.498 1.00 56.11 ? 373 LEU A O 1 ATOM 2985 C CB . LEU A 1 373 ? 29.331 41.805 19.672 1.00 49.66 ? 373 LEU A CB 1 ATOM 2986 C CG . LEU A 1 373 ? 28.723 42.796 18.707 1.00 48.54 ? 373 LEU A CG 1 ATOM 2987 C CD1 . LEU A 1 373 ? 27.509 43.438 19.341 1.00 48.51 ? 373 LEU A CD1 1 ATOM 2988 C CD2 . LEU A 1 373 ? 29.769 43.826 18.332 1.00 47.87 ? 373 LEU A CD2 1 ATOM 2989 N N . GLU A 1 374 ? 32.161 40.965 20.881 1.00 58.78 ? 374 GLU A N 1 ATOM 2990 C CA . GLU A 1 374 ? 32.879 40.339 21.988 1.00 61.30 ? 374 GLU A CA 1 ATOM 2991 C C . GLU A 1 374 ? 32.691 41.129 23.282 1.00 61.09 ? 374 GLU A C 1 ATOM 2992 O O . GLU A 1 374 ? 33.007 42.322 23.351 1.00 61.49 ? 374 GLU A O 1 ATOM 2993 C CB . GLU A 1 374 ? 34.379 40.246 21.672 1.00 64.05 ? 374 GLU A CB 1 ATOM 2994 C CG . GLU A 1 374 ? 35.202 39.528 22.743 1.00 68.73 ? 374 GLU A CG 1 ATOM 2995 C CD . GLU A 1 374 ? 36.586 40.138 22.948 1.00 72.09 ? 374 GLU A CD 1 ATOM 2996 O OE1 . GLU A 1 374 ? 36.669 41.288 23.446 1.00 73.49 ? 374 GLU A OE1 1 ATOM 2997 O OE2 . GLU A 1 374 ? 37.589 39.468 22.610 1.00 73.16 ? 374 GLU A OE2 1 ATOM 2998 N N . GLY A 1 375 ? 32.165 40.463 24.302 1.00 59.73 ? 375 GLY A N 1 ATOM 2999 C CA . GLY A 1 375 ? 31.976 41.119 25.581 1.00 58.18 ? 375 GLY A CA 1 ATOM 3000 C C . GLY A 1 375 ? 30.850 42.127 25.683 1.00 56.51 ? 375 GLY A C 1 ATOM 3001 O O . GLY A 1 375 ? 31.080 43.289 26.037 1.00 54.99 ? 375 GLY A O 1 ATOM 3002 N N . LEU A 1 376 ? 29.633 41.683 25.378 1.00 55.01 ? 376 LEU A N 1 ATOM 3003 C CA . LEU A 1 376 ? 28.464 42.547 25.464 1.00 54.45 ? 376 LEU A CA 1 ATOM 3004 C C . LEU A 1 376 ? 28.331 43.091 26.879 1.00 54.68 ? 376 LEU A C 1 ATOM 3005 O O . LEU A 1 376 ? 27.820 44.185 27.088 1.00 54.93 ? 376 LEU A O 1 ATOM 3006 C CB . LEU A 1 376 ? 27.199 41.774 25.113 1.00 52.94 ? 376 LEU A CB 1 ATOM 3007 C CG . LEU A 1 376 ? 26.951 41.457 23.646 1.00 51.52 ? 376 LEU A CG 1 ATOM 3008 C CD1 . LEU A 1 376 ? 25.654 40.664 23.498 1.00 51.72 ? 376 LEU A CD1 1 ATOM 3009 C CD2 . LEU A 1 376 ? 26.869 42.756 22.878 1.00 51.62 ? 376 LEU A CD2 1 ATOM 3010 N N . LYS A 1 377 ? 28.783 42.304 27.848 1.00 55.64 ? 377 LYS A N 1 ATOM 3011 C CA . LYS A 1 377 ? 28.734 42.684 29.253 1.00 56.09 ? 377 LYS A CA 1 ATOM 3012 C C . LYS A 1 377 ? 29.247 44.113 29.440 1.00 55.25 ? 377 LYS A C 1 ATOM 3013 O O . LYS A 1 377 ? 28.638 44.921 30.139 1.00 54.14 ? 377 LYS A O 1 ATOM 3014 C CB . LYS A 1 377 ? 29.592 41.708 30.073 1.00 58.82 ? 377 LYS A CB 1 ATOM 3015 C CG . LYS A 1 377 ? 29.991 42.198 31.472 1.00 63.46 ? 377 LYS A CG 1 ATOM 3016 C CD . LYS A 1 377 ? 31.160 41.377 32.052 1.00 65.43 ? 377 LYS A CD 1 ATOM 3017 C CE . LYS A 1 377 ? 31.625 41.896 33.422 1.00 66.15 ? 377 LYS A CE 1 ATOM 3018 N NZ . LYS A 1 377 ? 30.598 41.741 34.504 1.00 66.89 ? 377 LYS A NZ 1 ATOM 3019 N N . GLU A 1 378 ? 30.364 44.419 28.793 1.00 54.10 ? 378 GLU A N 1 ATOM 3020 C CA . GLU A 1 378 ? 30.975 45.730 28.908 1.00 53.56 ? 378 GLU A CA 1 ATOM 3021 C C . GLU A 1 378 ? 30.234 46.861 28.209 1.00 51.57 ? 378 GLU A C 1 ATOM 3022 O O . GLU A 1 378 ? 30.678 48.006 28.230 1.00 51.75 ? 378 GLU A O 1 ATOM 3023 C CB . GLU A 1 378 ? 32.414 45.655 28.401 1.00 56.51 ? 378 GLU A CB 1 ATOM 3024 C CG . GLU A 1 378 ? 33.433 45.316 29.487 1.00 61.58 ? 378 GLU A CG 1 ATOM 3025 C CD . GLU A 1 378 ? 33.027 44.116 30.337 1.00 65.12 ? 378 GLU A CD 1 ATOM 3026 O OE1 . GLU A 1 378 ? 32.871 43.008 29.776 1.00 67.15 ? 378 GLU A OE1 1 ATOM 3027 O OE2 . GLU A 1 378 ? 32.866 44.282 31.571 1.00 66.77 ? 378 GLU A OE2 1 ATOM 3028 N N . ALA A 1 379 ? 29.097 46.555 27.603 1.00 49.10 ? 379 ALA A N 1 ATOM 3029 C CA . ALA A 1 379 ? 28.345 47.583 26.904 1.00 47.21 ? 379 ALA A CA 1 ATOM 3030 C C . ALA A 1 379 ? 28.079 48.776 27.810 1.00 46.17 ? 379 ALA A C 1 ATOM 3031 O O . ALA A 1 379 ? 27.714 48.605 28.969 1.00 46.27 ? 379 ALA A O 1 ATOM 3032 C CB . ALA A 1 379 ? 27.037 47.014 26.400 1.00 46.41 ? 379 ALA A CB 1 ATOM 3033 N N . GLU A 1 380 ? 28.279 49.981 27.280 1.00 45.38 ? 380 GLU A N 1 ATOM 3034 C CA . GLU A 1 380 ? 28.033 51.204 28.037 1.00 44.36 ? 380 GLU A CA 1 ATOM 3035 C C . GLU A 1 380 ? 26.590 51.181 28.489 1.00 44.20 ? 380 GLU A C 1 ATOM 3036 O O . GLU A 1 380 ? 25.721 50.673 27.778 1.00 45.75 ? 380 GLU A O 1 ATOM 3037 C CB . GLU A 1 380 ? 28.260 52.433 27.164 1.00 44.12 ? 380 GLU A CB 1 ATOM 3038 C CG . GLU A 1 380 ? 29.711 52.712 26.879 1.00 47.18 ? 380 GLU A CG 1 ATOM 3039 C CD . GLU A 1 380 ? 29.944 53.176 25.465 1.00 49.75 ? 380 GLU A CD 1 ATOM 3040 O OE1 . GLU A 1 380 ? 29.720 52.369 24.534 1.00 53.44 ? 380 GLU A OE1 1 ATOM 3041 O OE2 . GLU A 1 380 ? 30.353 54.342 25.281 1.00 49.34 ? 380 GLU A OE2 1 ATOM 3042 N N . VAL A 1 381 ? 26.322 51.728 29.667 1.00 42.68 ? 381 VAL A N 1 ATOM 3043 C CA . VAL A 1 381 ? 24.958 51.736 30.172 1.00 40.36 ? 381 VAL A CA 1 ATOM 3044 C C . VAL A 1 381 ? 24.239 53.001 29.767 1.00 40.43 ? 381 VAL A C 1 ATOM 3045 O O . VAL A 1 381 ? 24.633 54.096 30.153 1.00 41.19 ? 381 VAL A O 1 ATOM 3046 C CB . VAL A 1 381 ? 24.930 51.638 31.689 1.00 37.51 ? 381 VAL A CB 1 ATOM 3047 C CG1 . VAL A 1 381 ? 23.524 51.316 32.158 1.00 34.88 ? 381 VAL A CG1 1 ATOM 3048 C CG2 . VAL A 1 381 ? 25.910 50.588 32.136 1.00 38.01 ? 381 VAL A CG2 1 ATOM 3049 N N . LEU A 1 382 ? 23.188 52.847 28.976 1.00 39.49 ? 382 LEU A N 1 ATOM 3050 C CA . LEU A 1 382 ? 22.406 53.986 28.533 1.00 39.45 ? 382 LEU A CA 1 ATOM 3051 C C . LEU A 1 382 ? 21.017 53.531 28.153 1.00 41.09 ? 382 LEU A C 1 ATOM 3052 O O . LEU A 1 382 ? 20.862 52.697 27.261 1.00 42.51 ? 382 LEU A O 1 ATOM 3053 C CB . LEU A 1 382 ? 23.050 54.660 27.321 1.00 36.16 ? 382 LEU A CB 1 ATOM 3054 C CG . LEU A 1 382 ? 22.092 55.637 26.631 1.00 34.19 ? 382 LEU A CG 1 ATOM 3055 C CD1 . LEU A 1 382 ? 21.762 56.768 27.579 1.00 32.44 ? 382 LEU A CD1 1 ATOM 3056 C CD2 . LEU A 1 382 ? 22.702 56.166 25.356 1.00 33.70 ? 382 LEU A CD2 1 ATOM 3057 N N . ASP A 1 383 ? 20.007 54.063 28.834 1.00 42.22 ? 383 ASP A N 1 ATOM 3058 C CA . ASP A 1 383 ? 18.632 53.710 28.513 1.00 42.81 ? 383 ASP A CA 1 ATOM 3059 C C . ASP A 1 383 ? 18.266 54.622 27.352 1.00 43.48 ? 383 ASP A C 1 ATOM 3060 O O . ASP A 1 383 ? 18.288 55.848 27.485 1.00 44.36 ? 383 ASP A O 1 ATOM 3061 C CB . ASP A 1 383 ? 17.722 53.970 29.702 1.00 44.00 ? 383 ASP A CB 1 ATOM 3062 C CG . ASP A 1 383 ? 16.299 53.548 29.440 1.00 46.96 ? 383 ASP A CG 1 ATOM 3063 O OD1 . ASP A 1 383 ? 15.595 54.252 28.689 1.00 46.75 ? 383 ASP A OD1 1 ATOM 3064 O OD2 . ASP A 1 383 ? 15.888 52.500 29.980 1.00 50.31 ? 383 ASP A OD2 1 ATOM 3065 N N . THR A 1 384 ? 17.945 54.026 26.209 1.00 43.17 ? 384 THR A N 1 ATOM 3066 C CA . THR A 1 384 ? 17.629 54.803 25.017 1.00 42.69 ? 384 THR A CA 1 ATOM 3067 C C . THR A 1 384 ? 16.141 55.028 24.768 1.00 42.85 ? 384 THR A C 1 ATOM 3068 O O . THR A 1 384 ? 15.730 55.348 23.655 1.00 43.44 ? 384 THR A O 1 ATOM 3069 C CB . THR A 1 384 ? 18.274 54.148 23.771 1.00 42.70 ? 384 THR A CB 1 ATOM 3070 O OG1 . THR A 1 384 ? 17.835 52.790 23.645 1.00 41.57 ? 384 THR A OG1 1 ATOM 3071 C CG2 . THR A 1 384 ? 19.788 54.162 23.898 1.00 42.91 ? 384 THR A CG2 1 ATOM 3072 N N . THR A 1 385 ? 15.337 54.885 25.815 1.00 42.97 ? 385 THR A N 1 ATOM 3073 C CA . THR A 1 385 ? 13.892 55.051 25.709 1.00 43.03 ? 385 THR A CA 1 ATOM 3074 C C . THR A 1 385 ? 13.425 56.348 25.030 1.00 42.01 ? 385 THR A C 1 ATOM 3075 O O . THR A 1 385 ? 12.587 56.306 24.131 1.00 41.66 ? 385 THR A O 1 ATOM 3076 C CB . THR A 1 385 ? 13.239 54.934 27.104 1.00 44.09 ? 385 THR A CB 1 ATOM 3077 O OG1 . THR A 1 385 ? 11.815 54.940 26.967 1.00 45.30 ? 385 THR A OG1 1 ATOM 3078 C CG2 . THR A 1 385 ? 13.666 56.101 28.002 1.00 46.18 ? 385 THR A CG2 1 ATOM 3079 N N . LEU A 1 386 ? 13.961 57.491 25.452 1.00 41.53 ? 386 LEU A N 1 ATOM 3080 C CA . LEU A 1 386 ? 13.572 58.773 24.872 1.00 41.19 ? 386 LEU A CA 1 ATOM 3081 C C . LEU A 1 386 ? 14.695 59.468 24.115 1.00 41.79 ? 386 LEU A C 1 ATOM 3082 O O . LEU A 1 386 ? 14.553 60.625 23.722 1.00 42.26 ? 386 LEU A O 1 ATOM 3083 C CB . LEU A 1 386 ? 13.063 59.717 25.961 1.00 40.68 ? 386 LEU A CB 1 ATOM 3084 C CG . LEU A 1 386 ? 11.770 59.334 26.674 1.00 39.84 ? 386 LEU A CG 1 ATOM 3085 C CD1 . LEU A 1 386 ? 11.516 60.313 27.797 1.00 40.19 ? 386 LEU A CD1 1 ATOM 3086 C CD2 . LEU A 1 386 ? 10.621 59.349 25.688 1.00 40.17 ? 386 LEU A CD2 1 ATOM 3087 N N . VAL A 1 387 ? 15.804 58.771 23.903 1.00 42.02 ? 387 VAL A N 1 ATOM 3088 C CA . VAL A 1 387 ? 16.944 59.352 23.198 1.00 42.84 ? 387 VAL A CA 1 ATOM 3089 C C . VAL A 1 387 ? 16.719 59.546 21.690 1.00 43.41 ? 387 VAL A C 1 ATOM 3090 O O . VAL A 1 387 ? 16.068 58.726 21.046 1.00 44.32 ? 387 VAL A O 1 ATOM 3091 C CB . VAL A 1 387 ? 18.197 58.477 23.407 1.00 42.36 ? 387 VAL A CB 1 ATOM 3092 C CG1 . VAL A 1 387 ? 19.388 59.068 22.659 1.00 42.72 ? 387 VAL A CG1 1 ATOM 3093 C CG2 . VAL A 1 387 ? 18.495 58.357 24.894 1.00 41.80 ? 387 VAL A CG2 1 ATOM 3094 N N . ASP A 1 388 ? 17.244 60.641 21.137 1.00 42.99 ? 388 ASP A N 1 ATOM 3095 C CA . ASP A 1 388 ? 17.130 60.911 19.704 1.00 42.06 ? 388 ASP A CA 1 ATOM 3096 C C . ASP A 1 388 ? 18.425 60.464 19.040 1.00 41.31 ? 388 ASP A C 1 ATOM 3097 O O . ASP A 1 388 ? 19.457 61.122 19.174 1.00 41.41 ? 388 ASP A O 1 ATOM 3098 C CB . ASP A 1 388 ? 16.909 62.398 19.435 1.00 43.48 ? 388 ASP A CB 1 ATOM 3099 C CG . ASP A 1 388 ? 17.200 62.774 17.986 1.00 46.12 ? 388 ASP A CG 1 ATOM 3100 O OD1 . ASP A 1 388 ? 17.003 61.917 17.094 1.00 46.01 ? 388 ASP A OD1 1 ATOM 3101 O OD2 . ASP A 1 388 ? 17.617 63.926 17.736 1.00 47.61 ? 388 ASP A OD2 1 ATOM 3102 N N . PRO A 1 389 ? 18.385 59.349 18.295 1.00 40.27 ? 389 PRO A N 1 ATOM 3103 C CA . PRO A 1 389 ? 19.584 58.841 17.633 1.00 40.06 ? 389 PRO A CA 1 ATOM 3104 C C . PRO A 1 389 ? 20.362 59.823 16.775 1.00 40.34 ? 389 PRO A C 1 ATOM 3105 O O . PRO A 1 389 ? 21.592 59.768 16.734 1.00 40.90 ? 389 PRO A O 1 ATOM 3106 C CB . PRO A 1 389 ? 19.064 57.636 16.853 1.00 38.27 ? 389 PRO A CB 1 ATOM 3107 C CG . PRO A 1 389 ? 17.678 58.005 16.557 1.00 38.59 ? 389 PRO A CG 1 ATOM 3108 C CD . PRO A 1 389 ? 17.205 58.589 17.861 1.00 38.86 ? 389 PRO A CD 1 ATOM 3109 N N . GLN A 1 390 ? 19.675 60.727 16.094 1.00 40.75 ? 390 GLN A N 1 ATOM 3110 C CA . GLN A 1 390 ? 20.409 61.676 15.273 1.00 42.48 ? 390 GLN A CA 1 ATOM 3111 C C . GLN A 1 390 ? 21.208 62.587 16.173 1.00 42.28 ? 390 GLN A C 1 ATOM 3112 O O . GLN A 1 390 ? 22.350 62.932 15.870 1.00 42.97 ? 390 GLN A O 1 ATOM 3113 C CB . GLN A 1 390 ? 19.474 62.510 14.403 1.00 44.40 ? 390 GLN A CB 1 ATOM 3114 C CG . GLN A 1 390 ? 20.202 63.615 13.661 1.00 45.63 ? 390 GLN A CG 1 ATOM 3115 C CD . GLN A 1 390 ? 19.336 64.285 12.626 1.00 49.24 ? 390 GLN A CD 1 ATOM 3116 O OE1 . GLN A 1 390 ? 18.133 64.471 12.831 1.00 51.71 ? 390 GLN A OE1 1 ATOM 3117 N NE2 . GLN A 1 390 ? 19.941 64.669 11.505 1.00 51.43 ? 390 GLN A NE2 1 ATOM 3118 N N . ALA A 1 391 ? 20.608 62.974 17.290 1.00 41.72 ? 391 ALA A N 1 ATOM 3119 C CA . ALA A 1 391 ? 21.290 63.841 18.235 1.00 40.93 ? 391 ALA A CA 1 ATOM 3120 C C . ALA A 1 391 ? 22.526 63.107 18.729 1.00 41.46 ? 391 ALA A C 1 ATOM 3121 O O . ALA A 1 391 ? 23.640 63.636 18.687 1.00 41.90 ? 391 ALA A O 1 ATOM 3122 C CB . ALA A 1 391 ? 20.371 64.158 19.395 1.00 39.08 ? 391 ALA A CB 1 ATOM 3123 N N . LEU A 1 392 ? 22.318 61.870 19.169 1.00 40.60 ? 392 LEU A N 1 ATOM 3124 C CA . LEU A 1 392 ? 23.398 61.056 19.686 1.00 40.83 ? 392 LEU A CA 1 ATOM 3125 C C . LEU A 1 392 ? 24.540 60.855 18.687 1.00 42.92 ? 392 LEU A C 1 ATOM 3126 O O . LEU A 1 392 ? 25.697 60.995 19.062 1.00 43.87 ? 392 LEU A O 1 ATOM 3127 C CB . LEU A 1 392 ? 22.845 59.713 20.154 1.00 39.75 ? 392 LEU A CB 1 ATOM 3128 C CG . LEU A 1 392 ? 23.747 58.888 21.068 1.00 38.69 ? 392 LEU A CG 1 ATOM 3129 C CD1 . LEU A 1 392 ? 24.252 59.759 22.202 1.00 39.43 ? 392 LEU A CD1 1 ATOM 3130 C CD2 . LEU A 1 392 ? 22.985 57.686 21.605 1.00 37.34 ? 392 LEU A CD2 1 ATOM 3131 N N . CYS A 1 393 ? 24.233 60.536 17.427 1.00 44.40 ? 393 CYS A N 1 ATOM 3132 C CA . CYS A 1 393 ? 25.289 60.335 16.424 1.00 46.89 ? 393 CYS A CA 1 ATOM 3133 C C . CYS A 1 393 ? 26.055 61.610 16.161 1.00 46.65 ? 393 CYS A C 1 ATOM 3134 O O . CYS A 1 393 ? 27.219 61.577 15.749 1.00 47.75 ? 393 CYS A O 1 ATOM 3135 C CB . CYS A 1 393 ? 24.732 59.864 15.080 1.00 49.83 ? 393 CYS A CB 1 ATOM 3136 S SG . CYS A 1 393 ? 24.098 58.160 15.032 1.00 60.80 ? 393 CYS A SG 1 ATOM 3137 N N . ASN A 1 394 ? 25.387 62.737 16.366 1.00 45.44 ? 394 ASN A N 1 ATOM 3138 C CA . ASN A 1 394 ? 26.018 64.021 16.151 1.00 43.57 ? 394 ASN A CA 1 ATOM 3139 C C . ASN A 1 394 ? 26.882 64.381 17.342 1.00 44.24 ? 394 ASN A C 1 ATOM 3140 O O . ASN A 1 394 ? 27.906 65.048 17.192 1.00 44.42 ? 394 ASN A O 1 ATOM 3141 C CB . ASN A 1 394 ? 24.958 65.077 15.907 1.00 42.17 ? 394 ASN A CB 1 ATOM 3142 C CG . ASN A 1 394 ? 24.603 65.198 14.448 1.00 42.32 ? 394 ASN A CG 1 ATOM 3143 O OD1 . ASN A 1 394 ? 25.420 65.633 13.640 1.00 43.13 ? 394 ASN A OD1 1 ATOM 3144 N ND2 . ASN A 1 394 ? 23.387 64.806 14.095 1.00 43.98 ? 394 ASN A ND2 1 ATOM 3145 N N . GLU A 1 395 ? 26.471 63.928 18.522 1.00 44.28 ? 395 GLU A N 1 ATOM 3146 C CA . GLU A 1 395 ? 27.224 64.185 19.741 1.00 45.80 ? 395 GLU A CA 1 ATOM 3147 C C . GLU A 1 395 ? 28.462 63.300 19.706 1.00 44.90 ? 395 GLU A C 1 ATOM 3148 O O . GLU A 1 395 ? 29.586 63.776 19.826 1.00 45.14 ? 395 GLU A O 1 ATOM 3149 C CB . GLU A 1 395 ? 26.374 63.837 20.963 1.00 49.37 ? 395 GLU A CB 1 ATOM 3150 C CG . GLU A 1 395 ? 27.023 64.101 22.319 1.00 54.85 ? 395 GLU A CG 1 ATOM 3151 C CD . GLU A 1 395 ? 26.236 63.458 23.467 1.00 60.67 ? 395 GLU A CD 1 ATOM 3152 O OE1 . GLU A 1 395 ? 26.604 63.652 24.650 1.00 62.56 ? 395 GLU A OE1 1 ATOM 3153 O OE2 . GLU A 1 395 ? 25.244 62.747 23.182 1.00 64.24 ? 395 GLU A OE2 1 ATOM 3154 N N . ARG A 1 396 ? 28.239 62.005 19.517 1.00 44.84 ? 396 ARG A N 1 ATOM 3155 C CA . ARG A 1 396 ? 29.314 61.024 19.475 1.00 44.39 ? 396 ARG A CA 1 ATOM 3156 C C . ARG A 1 396 ? 29.610 60.556 18.062 1.00 44.89 ? 396 ARG A C 1 ATOM 3157 O O . ARG A 1 396 ? 28.911 59.695 17.521 1.00 44.74 ? 396 ARG A O 1 ATOM 3158 C CB . ARG A 1 396 ? 28.943 59.813 20.322 1.00 44.21 ? 396 ARG A CB 1 ATOM 3159 C CG . ARG A 1 396 ? 28.487 60.172 21.711 1.00 44.79 ? 396 ARG A CG 1 ATOM 3160 C CD . ARG A 1 396 ? 29.416 59.578 22.721 1.00 46.15 ? 396 ARG A CD 1 ATOM 3161 N NE . ARG A 1 396 ? 28.843 58.413 23.379 1.00 48.42 ? 396 ARG A NE 1 ATOM 3162 C CZ . ARG A 1 396 ? 29.541 57.326 23.691 1.00 49.84 ? 396 ARG A CZ 1 ATOM 3163 N NH1 . ARG A 1 396 ? 30.835 57.264 23.391 1.00 48.60 ? 396 ARG A NH1 1 ATOM 3164 N NH2 . ARG A 1 396 ? 28.952 56.313 24.321 1.00 50.22 ? 396 ARG A NH2 1 ATOM 3165 N N . GLY A 1 397 ? 30.655 61.123 17.473 1.00 45.43 ? 397 GLY A N 1 ATOM 3166 C CA . GLY A 1 397 ? 31.037 60.746 16.128 1.00 45.82 ? 397 GLY A CA 1 ATOM 3167 C C . GLY A 1 397 ? 31.954 59.539 16.149 1.00 46.22 ? 397 GLY A C 1 ATOM 3168 O O . GLY A 1 397 ? 32.066 58.849 17.170 1.00 45.13 ? 397 GLY A O 1 ATOM 3169 N N . ALA A 1 398 ? 32.619 59.283 15.029 1.00 46.32 ? 398 ALA A N 1 ATOM 3170 C CA . ALA A 1 398 ? 33.516 58.139 14.941 1.00 46.04 ? 398 ALA A CA 1 ATOM 3171 C C . ALA A 1 398 ? 34.689 58.277 15.892 1.00 45.77 ? 398 ALA A C 1 ATOM 3172 O O . ALA A 1 398 ? 35.281 57.275 16.292 1.00 46.03 ? 398 ALA A O 1 ATOM 3173 C CB . ALA A 1 398 ? 34.020 57.977 13.524 1.00 46.18 ? 398 ALA A CB 1 ATOM 3174 N N . SER A 1 399 ? 35.016 59.518 16.254 1.00 45.17 ? 399 SER A N 1 ATOM 3175 C CA . SER A 1 399 ? 36.135 59.781 17.157 1.00 44.19 ? 399 SER A CA 1 ATOM 3176 C C . SER A 1 399 ? 35.783 59.585 18.636 1.00 43.67 ? 399 SER A C 1 ATOM 3177 O O . SER A 1 399 ? 36.661 59.614 19.502 1.00 44.20 ? 399 SER A O 1 ATOM 3178 C CB . SER A 1 399 ? 36.664 61.198 16.943 1.00 42.89 ? 399 SER A CB 1 ATOM 3179 O OG . SER A 1 399 ? 35.752 62.155 17.442 1.00 45.01 ? 399 SER A OG 1 ATOM 3180 N N . SER A 1 400 ? 34.502 59.388 18.926 1.00 42.81 ? 400 SER A N 1 ATOM 3181 C CA . SER A 1 400 ? 34.065 59.172 20.299 1.00 42.37 ? 400 SER A CA 1 ATOM 3182 C C . SER A 1 400 ? 34.169 57.681 20.614 1.00 43.08 ? 400 SER A C 1 ATOM 3183 O O . SER A 1 400 ? 33.235 56.914 20.355 1.00 44.76 ? 400 SER A O 1 ATOM 3184 C CB . SER A 1 400 ? 32.620 59.649 20.471 1.00 41.93 ? 400 SER A CB 1 ATOM 3185 O OG . SER A 1 400 ? 32.135 59.385 21.780 1.00 40.65 ? 400 SER A OG 1 ATOM 3186 N N . ARG A 1 401 ? 35.304 57.265 21.168 1.00 41.95 ? 401 ARG A N 1 ATOM 3187 C CA . ARG A 1 401 ? 35.498 55.856 21.488 1.00 42.24 ? 401 ARG A CA 1 ATOM 3188 C C . ARG A 1 401 ? 34.526 55.399 22.571 1.00 42.74 ? 401 ARG A C 1 ATOM 3189 O O . ARG A 1 401 ? 34.164 56.173 23.452 1.00 44.77 ? 401 ARG A O 1 ATOM 3190 C CB . ARG A 1 401 ? 36.944 55.624 21.921 1.00 41.57 ? 401 ARG A CB 1 ATOM 3191 C CG . ARG A 1 401 ? 37.947 56.186 20.924 1.00 42.79 ? 401 ARG A CG 1 ATOM 3192 C CD . ARG A 1 401 ? 39.351 55.712 21.209 1.00 43.70 ? 401 ARG A CD 1 ATOM 3193 N NE . ARG A 1 401 ? 39.430 54.258 21.200 1.00 47.18 ? 401 ARG A NE 1 ATOM 3194 C CZ . ARG A 1 401 ? 40.551 53.578 21.404 1.00 49.02 ? 401 ARG A CZ 1 ATOM 3195 N NH1 . ARG A 1 401 ? 41.680 54.236 21.631 1.00 50.10 ? 401 ARG A NH1 1 ATOM 3196 N NH2 . ARG A 1 401 ? 40.547 52.247 21.382 1.00 48.94 ? 401 ARG A NH2 1 ATOM 3197 N N . GLY A 1 402 ? 34.086 54.147 22.491 1.00 42.59 ? 402 GLY A N 1 ATOM 3198 C CA . GLY A 1 402 ? 33.159 53.621 23.479 1.00 41.90 ? 402 GLY A CA 1 ATOM 3199 C C . GLY A 1 402 ? 33.489 52.183 23.827 1.00 42.25 ? 402 GLY A C 1 ATOM 3200 O O . GLY A 1 402 ? 34.545 51.683 23.453 1.00 42.67 ? 402 GLY A O 1 ATOM 3201 N N . ALA A 1 403 ? 32.603 51.514 24.555 1.00 42.73 ? 403 ALA A N 1 ATOM 3202 C CA . ALA A 1 403 ? 32.831 50.118 24.920 1.00 43.63 ? 403 ALA A CA 1 ATOM 3203 C C . ALA A 1 403 ? 32.733 49.307 23.631 1.00 44.59 ? 403 ALA A C 1 ATOM 3204 O O . ALA A 1 403 ? 33.743 48.878 23.070 1.00 43.61 ? 403 ALA A O 1 ATOM 3205 C CB . ALA A 1 403 ? 31.772 49.663 25.909 1.00 44.47 ? 403 ALA A CB 1 ATOM 3206 N N . LEU A 1 404 ? 31.498 49.104 23.179 1.00 45.57 ? 404 LEU A N 1 ATOM 3207 C CA . LEU A 1 404 ? 31.215 48.395 21.940 1.00 45.25 ? 404 LEU A CA 1 ATOM 3208 C C . LEU A 1 404 ? 30.819 49.492 20.957 1.00 45.45 ? 404 LEU A C 1 ATOM 3209 O O . LEU A 1 404 ? 29.705 50.023 21.010 1.00 44.63 ? 404 LEU A O 1 ATOM 3210 C CB . LEU A 1 404 ? 30.051 47.422 22.128 1.00 46.04 ? 404 LEU A CB 1 ATOM 3211 C CG . LEU A 1 404 ? 30.234 46.267 23.115 1.00 46.75 ? 404 LEU A CG 1 ATOM 3212 C CD1 . LEU A 1 404 ? 28.905 45.554 23.319 1.00 47.20 ? 404 LEU A CD1 1 ATOM 3213 C CD2 . LEU A 1 404 ? 31.279 45.298 22.587 1.00 48.34 ? 404 LEU A CD2 1 ATOM 3214 N N . GLY A 1 405 ? 31.751 49.851 20.081 1.00 46.15 ? 405 GLY A N 1 ATOM 3215 C CA . GLY A 1 405 ? 31.485 50.892 19.105 1.00 46.41 ? 405 GLY A CA 1 ATOM 3216 C C . GLY A 1 405 ? 32.288 52.141 19.403 1.00 46.28 ? 405 GLY A C 1 ATOM 3217 O O . GLY A 1 405 ? 32.671 52.364 20.548 1.00 47.39 ? 405 GLY A O 1 ATOM 3218 N N . PRO A 1 406 ? 32.522 53.006 18.406 1.00 45.66 ? 406 PRO A N 1 ATOM 3219 C CA . PRO A 1 406 ? 32.072 52.859 17.020 1.00 44.32 ? 406 PRO A CA 1 ATOM 3220 C C . PRO A 1 406 ? 32.850 51.856 16.179 1.00 43.01 ? 406 PRO A C 1 ATOM 3221 O O . PRO A 1 406 ? 34.074 51.911 16.109 1.00 43.58 ? 406 PRO A O 1 ATOM 3222 C CB . PRO A 1 406 ? 32.217 54.275 16.477 1.00 44.32 ? 406 PRO A CB 1 ATOM 3223 C CG . PRO A 1 406 ? 33.478 54.729 17.144 1.00 44.93 ? 406 PRO A CG 1 ATOM 3224 C CD . PRO A 1 406 ? 33.244 54.280 18.581 1.00 46.18 ? 406 PRO A CD 1 ATOM 3225 N N . PHE A 1 407 ? 32.132 50.934 15.548 1.00 41.20 ? 407 PHE A N 1 ATOM 3226 C CA . PHE A 1 407 ? 32.756 49.966 14.659 1.00 39.64 ? 407 PHE A CA 1 ATOM 3227 C C . PHE A 1 407 ? 31.902 49.904 13.398 1.00 40.25 ? 407 PHE A C 1 ATOM 3228 O O . PHE A 1 407 ? 30.673 49.766 13.465 1.00 41.78 ? 407 PHE A O 1 ATOM 3229 C CB . PHE A 1 407 ? 32.872 48.585 15.316 1.00 36.91 ? 407 PHE A CB 1 ATOM 3230 C CG . PHE A 1 407 ? 31.564 47.968 15.691 1.00 34.74 ? 407 PHE A CG 1 ATOM 3231 C CD1 . PHE A 1 407 ? 30.803 47.283 14.753 1.00 34.10 ? 407 PHE A CD1 1 ATOM 3232 C CD2 . PHE A 1 407 ? 31.091 48.069 16.993 1.00 33.97 ? 407 PHE A CD2 1 ATOM 3233 C CE1 . PHE A 1 407 ? 29.592 46.695 15.114 1.00 34.94 ? 407 PHE A CE1 1 ATOM 3234 C CE2 . PHE A 1 407 ? 29.887 47.488 17.365 1.00 32.91 ? 407 PHE A CE2 1 ATOM 3235 C CZ . PHE A 1 407 ? 29.132 46.803 16.426 1.00 34.19 ? 407 PHE A CZ 1 ATOM 3236 N N . GLY A 1 408 ? 32.554 50.047 12.251 1.00 39.09 ? 408 GLY A N 1 ATOM 3237 C CA . GLY A 1 408 ? 31.834 50.014 10.997 1.00 38.61 ? 408 GLY A CA 1 ATOM 3238 C C . GLY A 1 408 ? 32.719 50.244 9.790 1.00 38.78 ? 408 GLY A C 1 ATOM 3239 O O . GLY A 1 408 ? 33.785 49.645 9.657 1.00 39.94 ? 408 GLY A O 1 ATOM 3240 N N . LEU A 1 409 ? 32.274 51.127 8.906 1.00 38.24 ? 409 LEU A N 1 ATOM 3241 C CA . LEU A 1 409 ? 33.007 51.429 7.686 1.00 36.65 ? 409 LEU A CA 1 ATOM 3242 C C . LEU A 1 409 ? 33.407 52.886 7.547 1.00 37.08 ? 409 LEU A C 1 ATOM 3243 O O . LEU A 1 409 ? 32.852 53.777 8.196 1.00 36.65 ? 409 LEU A O 1 ATOM 3244 C CB . LEU A 1 409 ? 32.159 51.061 6.473 1.00 34.83 ? 409 LEU A CB 1 ATOM 3245 C CG . LEU A 1 409 ? 32.655 49.915 5.617 1.00 34.93 ? 409 LEU A CG 1 ATOM 3246 C CD1 . LEU A 1 409 ? 32.794 48.675 6.472 1.00 35.75 ? 409 LEU A CD1 1 ATOM 3247 C CD2 . LEU A 1 409 ? 31.681 49.677 4.474 1.00 35.70 ? 409 LEU A CD2 1 ATOM 3248 N N . LEU A 1 410 ? 34.383 53.110 6.679 1.00 36.62 ? 410 LEU A N 1 ATOM 3249 C CA . LEU A 1 410 ? 34.852 54.445 6.364 1.00 36.59 ? 410 LEU A CA 1 ATOM 3250 C C . LEU A 1 410 ? 34.752 54.481 4.851 1.00 37.55 ? 410 LEU A C 1 ATOM 3251 O O . LEU A 1 410 ? 35.638 53.973 4.163 1.00 39.24 ? 410 LEU A O 1 ATOM 3252 C CB . LEU A 1 410 ? 36.307 54.636 6.785 1.00 35.03 ? 410 LEU A CB 1 ATOM 3253 C CG . LEU A 1 410 ? 36.612 54.551 8.279 1.00 34.32 ? 410 LEU A CG 1 ATOM 3254 C CD1 . LEU A 1 410 ? 38.069 54.907 8.497 1.00 34.48 ? 410 LEU A CD1 1 ATOM 3255 C CD2 . LEU A 1 410 ? 35.711 55.493 9.051 1.00 32.13 ? 410 LEU A CD2 1 ATOM 3256 N N . ALA A 1 411 ? 33.662 55.044 4.336 1.00 37.11 ? 411 ALA A N 1 ATOM 3257 C CA . ALA A 1 411 ? 33.442 55.126 2.898 1.00 36.89 ? 411 ALA A CA 1 ATOM 3258 C C . ALA A 1 411 ? 33.926 56.470 2.361 1.00 37.67 ? 411 ALA A C 1 ATOM 3259 O O . ALA A 1 411 ? 34.101 57.416 3.125 1.00 37.11 ? 411 ALA A O 1 ATOM 3260 C CB . ALA A 1 411 ? 31.964 54.936 2.596 1.00 36.31 ? 411 ALA A CB 1 ATOM 3261 N N . MET A 1 412 ? 34.146 56.549 1.049 1.00 39.22 ? 412 MET A N 1 ATOM 3262 C CA . MET A 1 412 ? 34.610 57.784 0.417 1.00 40.60 ? 412 MET A CA 1 ATOM 3263 C C . MET A 1 412 ? 35.652 58.470 1.297 1.00 43.09 ? 412 MET A C 1 ATOM 3264 O O . MET A 1 412 ? 35.505 59.648 1.631 1.00 44.07 ? 412 MET A O 1 ATOM 3265 C CB . MET A 1 412 ? 33.433 58.740 0.185 1.00 38.47 ? 412 MET A CB 1 ATOM 3266 C CG . MET A 1 412 ? 32.395 58.265 -0.817 1.00 36.38 ? 412 MET A CG 1 ATOM 3267 S SD . MET A 1 412 ? 33.084 57.832 -2.450 1.00 34.73 ? 412 MET A SD 1 ATOM 3268 C CE . MET A 1 412 ? 34.062 59.278 -2.860 1.00 35.05 ? 412 MET A CE 1 ATOM 3269 N N . ALA A 1 413 ? 36.702 57.736 1.665 1.00 45.18 ? 413 ALA A N 1 ATOM 3270 C CA . ALA A 1 413 ? 37.751 58.275 2.529 1.00 47.48 ? 413 ALA A CA 1 ATOM 3271 C C . ALA A 1 413 ? 39.066 58.551 1.818 1.00 49.17 ? 413 ALA A C 1 ATOM 3272 O O . ALA A 1 413 ? 39.388 57.907 0.820 1.00 49.38 ? 413 ALA A O 1 ATOM 3273 C CB . ALA A 1 413 ? 37.992 57.326 3.697 1.00 47.13 ? 413 ALA A CB 1 ATOM 3274 N N . SER A 1 414 ? 39.819 59.514 2.352 1.00 51.22 ? 414 SER A N 1 ATOM 3275 C CA . SER A 1 414 ? 41.124 59.900 1.814 1.00 53.21 ? 414 SER A CA 1 ATOM 3276 C C . SER A 1 414 ? 42.116 58.803 2.135 1.00 54.36 ? 414 SER A C 1 ATOM 3277 O O . SER A 1 414 ? 41.927 58.048 3.083 1.00 55.15 ? 414 SER A O 1 ATOM 3278 C CB . SER A 1 414 ? 41.638 61.181 2.476 1.00 52.84 ? 414 SER A CB 1 ATOM 3279 O OG . SER A 1 414 ? 40.704 62.236 2.400 1.00 56.24 ? 414 SER A OG 1 ATOM 3280 N N . LYS A 1 415 ? 43.186 58.725 1.361 1.00 55.67 ? 415 LYS A N 1 ATOM 3281 C CA . LYS A 1 415 ? 44.202 57.725 1.623 1.00 57.06 ? 415 LYS A CA 1 ATOM 3282 C C . LYS A 1 415 ? 44.719 57.951 3.047 1.00 56.41 ? 415 LYS A C 1 ATOM 3283 O O . LYS A 1 415 ? 45.080 57.009 3.743 1.00 57.05 ? 415 LYS A O 1 ATOM 3284 C CB . LYS A 1 415 ? 45.339 57.879 0.613 1.00 60.35 ? 415 LYS A CB 1 ATOM 3285 C CG . LYS A 1 415 ? 46.431 56.818 0.686 1.00 65.01 ? 415 LYS A CG 1 ATOM 3286 C CD . LYS A 1 415 ? 47.413 56.972 -0.489 1.00 68.87 ? 415 LYS A CD 1 ATOM 3287 C CE . LYS A 1 415 ? 48.514 55.903 -0.490 1.00 70.58 ? 415 LYS A CE 1 ATOM 3288 N NZ . LYS A 1 415 ? 49.459 56.012 0.669 1.00 71.36 ? 415 LYS A NZ 1 ATOM 3289 N N . ASP A 1 416 ? 44.716 59.209 3.479 1.00 55.84 ? 416 ASP A N 1 ATOM 3290 C CA . ASP A 1 416 ? 45.202 59.602 4.803 1.00 54.84 ? 416 ASP A CA 1 ATOM 3291 C C . ASP A 1 416 ? 44.087 59.867 5.812 1.00 53.65 ? 416 ASP A C 1 ATOM 3292 O O . ASP A 1 416 ? 44.333 60.410 6.890 1.00 52.25 ? 416 ASP A O 1 ATOM 3293 C CB . ASP A 1 416 ? 46.048 60.865 4.674 1.00 57.34 ? 416 ASP A CB 1 ATOM 3294 C CG . ASP A 1 416 ? 45.248 62.052 4.143 1.00 60.51 ? 416 ASP A CG 1 ATOM 3295 O OD1 . ASP A 1 416 ? 44.629 61.930 3.065 1.00 62.59 ? 416 ASP A OD1 1 ATOM 3296 O OD2 . ASP A 1 416 ? 45.240 63.112 4.804 1.00 62.45 ? 416 ASP A OD2 1 ATOM 3297 N N . LEU A 1 417 ? 42.866 59.486 5.452 1.00 52.63 ? 417 LEU A N 1 ATOM 3298 C CA . LEU A 1 417 ? 41.695 59.688 6.302 1.00 51.37 ? 417 LEU A CA 1 ATOM 3299 C C . LEU A 1 417 ? 41.435 61.138 6.738 1.00 52.03 ? 417 LEU A C 1 ATOM 3300 O O . LEU A 1 417 ? 40.824 61.383 7.784 1.00 51.34 ? 417 LEU A O 1 ATOM 3301 C CB . LEU A 1 417 ? 41.760 58.780 7.530 1.00 47.98 ? 417 LEU A CB 1 ATOM 3302 C CG . LEU A 1 417 ? 41.080 57.429 7.318 1.00 46.03 ? 417 LEU A CG 1 ATOM 3303 C CD1 . LEU A 1 417 ? 41.902 56.584 6.395 1.00 45.86 ? 417 LEU A CD1 1 ATOM 3304 C CD2 . LEU A 1 417 ? 40.916 56.733 8.635 1.00 46.31 ? 417 LEU A CD2 1 ATOM 3305 N N . LYS A 1 418 ? 41.888 62.097 5.932 1.00 52.64 ? 418 LYS A N 1 ATOM 3306 C CA . LYS A 1 418 ? 41.659 63.506 6.240 1.00 52.85 ? 418 LYS A CA 1 ATOM 3307 C C . LYS A 1 418 ? 40.146 63.684 6.146 1.00 51.11 ? 418 LYS A C 1 ATOM 3308 O O . LYS A 1 418 ? 39.521 64.323 6.998 1.00 51.38 ? 418 LYS A O 1 ATOM 3309 C CB . LYS A 1 418 ? 42.365 64.395 5.210 1.00 56.51 ? 418 LYS A CB 1 ATOM 3310 C CG . LYS A 1 418 ? 42.305 65.903 5.484 1.00 60.71 ? 418 LYS A CG 1 ATOM 3311 C CD . LYS A 1 418 ? 42.881 66.716 4.296 1.00 66.04 ? 418 LYS A CD 1 ATOM 3312 C CE . LYS A 1 418 ? 42.079 66.486 2.984 1.00 69.15 ? 418 LYS A CE 1 ATOM 3313 N NZ . LYS A 1 418 ? 42.530 67.303 1.800 1.00 68.48 ? 418 LYS A NZ 1 ATOM 3314 N N . GLU A 1 419 ? 39.575 63.087 5.100 1.00 48.26 ? 419 GLU A N 1 ATOM 3315 C CA . GLU A 1 419 ? 38.140 63.114 4.832 1.00 45.07 ? 419 GLU A CA 1 ATOM 3316 C C . GLU A 1 419 ? 37.624 61.672 4.843 1.00 43.93 ? 419 GLU A C 1 ATOM 3317 O O . GLU A 1 419 ? 38.217 60.779 4.233 1.00 42.59 ? 419 GLU A O 1 ATOM 3318 C CB . GLU A 1 419 ? 37.875 63.755 3.472 1.00 43.90 ? 419 GLU A CB 1 ATOM 3319 C CG . GLU A 1 419 ? 38.285 65.205 3.390 1.00 45.19 ? 419 GLU A CG 1 ATOM 3320 C CD . GLU A 1 419 ? 38.156 65.763 1.990 1.00 47.23 ? 419 GLU A CD 1 ATOM 3321 O OE1 . GLU A 1 419 ? 38.942 65.353 1.104 1.00 47.71 ? 419 GLU A OE1 1 ATOM 3322 O OE2 . GLU A 1 419 ? 37.261 66.610 1.773 1.00 48.25 ? 419 GLU A OE2 1 ATOM 3323 N N . GLN A 1 420 ? 36.514 61.453 5.538 1.00 42.93 ? 420 GLN A N 1 ATOM 3324 C CA . GLN A 1 420 ? 35.937 60.120 5.659 1.00 41.30 ? 420 GLN A CA 1 ATOM 3325 C C . GLN A 1 420 ? 34.475 60.169 6.081 1.00 40.44 ? 420 GLN A C 1 ATOM 3326 O O . GLN A 1 420 ? 34.053 61.074 6.801 1.00 41.70 ? 420 GLN A O 1 ATOM 3327 C CB . GLN A 1 420 ? 36.712 59.318 6.712 1.00 40.27 ? 420 GLN A CB 1 ATOM 3328 C CG . GLN A 1 420 ? 36.882 60.092 8.018 1.00 40.19 ? 420 GLN A CG 1 ATOM 3329 C CD . GLN A 1 420 ? 37.338 59.244 9.191 1.00 41.24 ? 420 GLN A CD 1 ATOM 3330 O OE1 . GLN A 1 420 ? 36.551 58.506 9.776 1.00 41.76 ? 420 GLN A OE1 1 ATOM 3331 N NE2 . GLN A 1 420 ? 38.614 59.355 9.546 1.00 42.09 ? 420 GLN A NE2 1 ATOM 3332 N N . SER A 1 421 ? 33.707 59.186 5.635 1.00 38.69 ? 421 SER A N 1 ATOM 3333 C CA . SER A 1 421 ? 32.308 59.090 6.014 1.00 37.68 ? 421 SER A CA 1 ATOM 3334 C C . SER A 1 421 ? 32.194 57.775 6.765 1.00 36.60 ? 421 SER A C 1 ATOM 3335 O O . SER A 1 421 ? 32.356 56.701 6.192 1.00 37.12 ? 421 SER A O 1 ATOM 3336 C CB . SER A 1 421 ? 31.411 59.107 4.781 1.00 37.63 ? 421 SER A CB 1 ATOM 3337 O OG . SER A 1 421 ? 31.515 60.362 4.128 1.00 39.79 ? 421 SER A OG 1 ATOM 3338 N N . ALA A 1 422 ? 31.939 57.869 8.062 1.00 35.01 ? 422 ALA A N 1 ATOM 3339 C CA . ALA A 1 422 ? 31.855 56.688 8.892 1.00 33.72 ? 422 ALA A CA 1 ATOM 3340 C C . ALA A 1 422 ? 30.448 56.199 9.127 1.00 33.73 ? 422 ALA A C 1 ATOM 3341 O O . ALA A 1 422 ? 29.612 56.919 9.671 1.00 33.48 ? 422 ALA A O 1 ATOM 3342 C CB . ALA A 1 422 ? 32.527 56.954 10.221 1.00 32.96 ? 422 ALA A CB 1 ATOM 3343 N N . ILE A 1 423 ? 30.191 54.969 8.695 1.00 33.27 ? 423 ILE A N 1 ATOM 3344 C CA . ILE A 1 423 ? 28.893 54.344 8.908 1.00 32.67 ? 423 ILE A CA 1 ATOM 3345 C C . ILE A 1 423 ? 29.176 53.282 9.971 1.00 33.11 ? 423 ILE A C 1 ATOM 3346 O O . ILE A 1 423 ? 29.853 52.286 9.703 1.00 32.83 ? 423 ILE A O 1 ATOM 3347 C CB . ILE A 1 423 ? 28.334 53.704 7.608 1.00 30.08 ? 423 ILE A CB 1 ATOM 3348 C CG1 . ILE A 1 423 ? 27.857 54.800 6.662 1.00 29.43 ? 423 ILE A CG1 1 ATOM 3349 C CG2 . ILE A 1 423 ? 27.147 52.802 7.923 1.00 28.81 ? 423 ILE A CG2 1 ATOM 3350 C CD1 . ILE A 1 423 ? 28.939 55.702 6.182 1.00 31.37 ? 423 ILE A CD1 1 ATOM 3351 N N . PHE A 1 424 ? 28.676 53.501 11.183 1.00 32.81 ? 424 PHE A N 1 ATOM 3352 C CA . PHE A 1 424 ? 28.951 52.561 12.254 1.00 32.79 ? 424 PHE A CA 1 ATOM 3353 C C . PHE A 1 424 ? 27.820 52.254 13.232 1.00 33.88 ? 424 PHE A C 1 ATOM 3354 O O . PHE A 1 424 ? 26.716 52.811 13.158 1.00 32.71 ? 424 PHE A O 1 ATOM 3355 C CB . PHE A 1 424 ? 30.144 53.069 13.043 1.00 32.53 ? 424 PHE A CB 1 ATOM 3356 C CG . PHE A 1 424 ? 29.909 54.398 13.697 1.00 31.66 ? 424 PHE A CG 1 ATOM 3357 C CD1 . PHE A 1 424 ? 29.171 54.491 14.874 1.00 30.06 ? 424 PHE A CD1 1 ATOM 3358 C CD2 . PHE A 1 424 ? 30.435 55.559 13.141 1.00 32.99 ? 424 PHE A CD2 1 ATOM 3359 C CE1 . PHE A 1 424 ? 28.964 55.718 15.491 1.00 30.35 ? 424 PHE A CE1 1 ATOM 3360 C CE2 . PHE A 1 424 ? 30.234 56.799 13.751 1.00 32.98 ? 424 PHE A CE2 1 ATOM 3361 C CZ . PHE A 1 424 ? 29.497 56.875 14.929 1.00 32.02 ? 424 PHE A CZ 1 ATOM 3362 N N . PHE A 1 425 ? 28.136 51.359 14.165 1.00 34.61 ? 425 PHE A N 1 ATOM 3363 C CA . PHE A 1 425 ? 27.208 50.929 15.199 1.00 35.03 ? 425 PHE A CA 1 ATOM 3364 C C . PHE A 1 425 ? 27.776 51.176 16.595 1.00 35.57 ? 425 PHE A C 1 ATOM 3365 O O . PHE A 1 425 ? 28.979 51.372 16.768 1.00 35.35 ? 425 PHE A O 1 ATOM 3366 C CB . PHE A 1 425 ? 26.928 49.439 15.059 1.00 34.33 ? 425 PHE A CB 1 ATOM 3367 C CG . PHE A 1 425 ? 26.263 49.064 13.782 1.00 32.72 ? 425 PHE A CG 1 ATOM 3368 C CD1 . PHE A 1 425 ? 24.915 49.342 13.584 1.00 32.13 ? 425 PHE A CD1 1 ATOM 3369 C CD2 . PHE A 1 425 ? 26.977 48.404 12.783 1.00 32.03 ? 425 PHE A CD2 1 ATOM 3370 C CE1 . PHE A 1 425 ? 24.279 48.969 12.404 1.00 32.63 ? 425 PHE A CE1 1 ATOM 3371 C CE2 . PHE A 1 425 ? 26.359 48.024 11.598 1.00 31.89 ? 425 PHE A CE2 1 ATOM 3372 C CZ . PHE A 1 425 ? 25.004 48.304 11.407 1.00 32.74 ? 425 PHE A CZ 1 ATOM 3373 N N . ARG A 1 426 ? 26.883 51.154 17.580 1.00 35.61 ? 426 ARG A N 1 ATOM 3374 C CA . ARG A 1 426 ? 27.216 51.336 18.990 1.00 35.78 ? 426 ARG A CA 1 ATOM 3375 C C . ARG A 1 426 ? 26.258 50.409 19.715 1.00 35.94 ? 426 ARG A C 1 ATOM 3376 O O . ARG A 1 426 ? 25.121 50.238 19.280 1.00 36.72 ? 426 ARG A O 1 ATOM 3377 C CB . ARG A 1 426 ? 26.949 52.778 19.432 1.00 36.26 ? 426 ARG A CB 1 ATOM 3378 C CG . ARG A 1 426 ? 28.082 53.747 19.174 1.00 37.67 ? 426 ARG A CG 1 ATOM 3379 C CD . ARG A 1 426 ? 28.653 54.271 20.492 1.00 39.61 ? 426 ARG A CD 1 ATOM 3380 N NE . ARG A 1 426 ? 29.795 55.159 20.279 1.00 39.00 ? 426 ARG A NE 1 ATOM 3381 C CZ . ARG A 1 426 ? 29.741 56.269 19.555 1.00 38.51 ? 426 ARG A CZ 1 ATOM 3382 N NH1 . ARG A 1 426 ? 28.597 56.633 18.976 1.00 37.72 ? 426 ARG A NH1 1 ATOM 3383 N NH2 . ARG A 1 426 ? 30.833 57.002 19.396 1.00 37.41 ? 426 ARG A NH2 1 ATOM 3384 N N . VAL A 1 427 ? 26.698 49.793 20.801 1.00 35.65 ? 427 VAL A N 1 ATOM 3385 C CA . VAL A 1 427 ? 25.799 48.914 21.533 1.00 36.39 ? 427 VAL A CA 1 ATOM 3386 C C . VAL A 1 427 ? 25.729 49.375 22.976 1.00 38.04 ? 427 VAL A C 1 ATOM 3387 O O . VAL A 1 427 ? 26.759 49.553 23.632 1.00 39.37 ? 427 VAL A O 1 ATOM 3388 C CB . VAL A 1 427 ? 26.264 47.441 21.484 1.00 35.88 ? 427 VAL A CB 1 ATOM 3389 C CG1 . VAL A 1 427 ? 25.320 46.569 22.288 1.00 34.29 ? 427 VAL A CG1 1 ATOM 3390 C CG2 . VAL A 1 427 ? 26.304 46.958 20.045 1.00 36.55 ? 427 VAL A CG2 1 ATOM 3391 N N . PHE A 1 428 ? 24.513 49.587 23.463 1.00 38.26 ? 428 PHE A N 1 ATOM 3392 C CA . PHE A 1 428 ? 24.319 50.032 24.833 1.00 39.05 ? 428 PHE A CA 1 ATOM 3393 C C . PHE A 1 428 ? 23.485 49.024 25.600 1.00 41.27 ? 428 PHE A C 1 ATOM 3394 O O . PHE A 1 428 ? 23.085 47.992 25.063 1.00 41.79 ? 428 PHE A O 1 ATOM 3395 C CB . PHE A 1 428 ? 23.578 51.357 24.848 1.00 37.12 ? 428 PHE A CB 1 ATOM 3396 C CG . PHE A 1 428 ? 24.254 52.432 24.085 1.00 37.04 ? 428 PHE A CG 1 ATOM 3397 C CD1 . PHE A 1 428 ? 25.405 53.034 24.582 1.00 38.13 ? 428 PHE A CD1 1 ATOM 3398 C CD2 . PHE A 1 428 ? 23.720 52.881 22.881 1.00 37.99 ? 428 PHE A CD2 1 ATOM 3399 C CE1 . PHE A 1 428 ? 26.025 54.080 23.885 1.00 38.56 ? 428 PHE A CE1 1 ATOM 3400 C CE2 . PHE A 1 428 ? 24.327 53.924 22.173 1.00 38.77 ? 428 PHE A CE2 1 ATOM 3401 C CZ . PHE A 1 428 ? 25.479 54.527 22.681 1.00 39.08 ? 428 PHE A CZ 1 ATOM 3402 N N . GLN A 1 429 ? 23.227 49.338 26.865 1.00 43.38 ? 429 GLN A N 1 ATOM 3403 C CA . GLN A 1 429 ? 22.392 48.507 27.721 1.00 45.05 ? 429 GLN A CA 1 ATOM 3404 C C . GLN A 1 429 ? 21.831 49.385 28.826 1.00 46.01 ? 429 GLN A C 1 ATOM 3405 O O . GLN A 1 429 ? 22.516 50.286 29.318 1.00 44.49 ? 429 GLN A O 1 ATOM 3406 C CB . GLN A 1 429 ? 23.187 47.350 28.326 1.00 45.16 ? 429 GLN A CB 1 ATOM 3407 C CG . GLN A 1 429 ? 24.403 47.763 29.124 1.00 45.66 ? 429 GLN A CG 1 ATOM 3408 C CD . GLN A 1 429 ? 24.958 46.619 29.951 1.00 45.93 ? 429 GLN A CD 1 ATOM 3409 O OE1 . GLN A 1 429 ? 26.125 46.632 30.334 1.00 46.60 ? 429 GLN A OE1 1 ATOM 3410 N NE2 . GLN A 1 429 ? 24.118 45.627 30.238 1.00 45.30 ? 429 GLN A NE2 1 ATOM 3411 N N . ASN A 1 430 ? 20.580 49.137 29.199 1.00 47.56 ? 430 ASN A N 1 ATOM 3412 C CA . ASN A 1 430 ? 19.950 49.918 30.251 1.00 49.94 ? 430 ASN A CA 1 ATOM 3413 C C . ASN A 1 430 ? 20.242 49.285 31.604 1.00 52.30 ? 430 ASN A C 1 ATOM 3414 O O . ASN A 1 430 ? 20.910 48.253 31.690 1.00 51.87 ? 430 ASN A O 1 ATOM 3415 C CB . ASN A 1 430 ? 18.435 50.013 30.033 1.00 48.78 ? 430 ASN A CB 1 ATOM 3416 C CG . ASN A 1 430 ? 17.771 48.656 29.951 1.00 48.81 ? 430 ASN A CG 1 ATOM 3417 O OD1 . ASN A 1 430 ? 18.349 47.649 30.349 1.00 49.43 ? 430 ASN A OD1 1 ATOM 3418 N ND2 . ASN A 1 430 ? 16.544 48.624 29.444 1.00 47.86 ? 430 ASN A ND2 1 ATOM 3419 N N . GLN A 1 431 ? 19.738 49.910 32.660 1.00 55.20 ? 431 GLN A N 1 ATOM 3420 C CA . GLN A 1 431 ? 19.953 49.411 34.005 1.00 57.79 ? 431 GLN A CA 1 ATOM 3421 C C . GLN A 1 431 ? 19.299 48.056 34.229 1.00 57.83 ? 431 GLN A C 1 ATOM 3422 O O . GLN A 1 431 ? 19.411 47.477 35.305 1.00 60.00 ? 431 GLN A O 1 ATOM 3423 C CB . GLN A 1 431 ? 19.438 50.432 35.017 1.00 59.71 ? 431 GLN A CB 1 ATOM 3424 C CG . GLN A 1 431 ? 20.237 51.728 35.002 1.00 64.62 ? 431 GLN A CG 1 ATOM 3425 C CD . GLN A 1 431 ? 21.685 51.539 35.472 1.00 67.82 ? 431 GLN A CD 1 ATOM 3426 O OE1 . GLN A 1 431 ? 22.493 52.477 35.427 1.00 69.33 ? 431 GLN A OE1 1 ATOM 3427 N NE2 . GLN A 1 431 ? 22.012 50.329 35.935 1.00 67.16 ? 431 GLN A NE2 1 ATOM 3428 N N . LEU A 1 432 ? 18.624 47.547 33.206 1.00 56.68 ? 432 LEU A N 1 ATOM 3429 C CA . LEU A 1 432 ? 17.960 46.254 33.302 1.00 55.96 ? 432 LEU A CA 1 ATOM 3430 C C . LEU A 1 432 ? 18.633 45.212 32.423 1.00 57.26 ? 432 LEU A C 1 ATOM 3431 O O . LEU A 1 432 ? 18.077 44.143 32.190 1.00 57.59 ? 432 LEU A O 1 ATOM 3432 C CB . LEU A 1 432 ? 16.492 46.389 32.910 1.00 54.41 ? 432 LEU A CB 1 ATOM 3433 C CG . LEU A 1 432 ? 15.494 46.675 34.030 1.00 53.60 ? 432 LEU A CG 1 ATOM 3434 C CD1 . LEU A 1 432 ? 15.968 47.830 34.893 1.00 54.57 ? 432 LEU A CD1 1 ATOM 3435 C CD2 . LEU A 1 432 ? 14.139 46.974 33.413 1.00 53.41 ? 432 LEU A CD2 1 ATOM 3436 N N . GLY A 1 433 ? 19.823 45.531 31.923 1.00 58.13 ? 433 GLY A N 1 ATOM 3437 C CA . GLY A 1 433 ? 20.549 44.589 31.089 1.00 59.49 ? 433 GLY A CA 1 ATOM 3438 C C . GLY A 1 433 ? 20.046 44.370 29.669 1.00 60.95 ? 433 GLY A C 1 ATOM 3439 O O . GLY A 1 433 ? 20.520 43.463 28.977 1.00 61.71 ? 433 GLY A O 1 ATOM 3440 N N . ARG A 1 434 ? 19.085 45.175 29.227 1.00 61.47 ? 434 ARG A N 1 ATOM 3441 C CA . ARG A 1 434 ? 18.566 45.046 27.872 1.00 61.75 ? 434 ARG A CA 1 ATOM 3442 C C . ARG A 1 434 ? 19.417 45.858 26.900 1.00 59.56 ? 434 ARG A C 1 ATOM 3443 O O . ARG A 1 434 ? 19.781 47.003 27.174 1.00 59.55 ? 434 ARG A O 1 ATOM 3444 C CB . ARG A 1 434 ? 17.109 45.486 27.828 1.00 65.89 ? 434 ARG A CB 1 ATOM 3445 C CG . ARG A 1 434 ? 16.177 44.389 28.287 1.00 73.21 ? 434 ARG A CG 1 ATOM 3446 C CD . ARG A 1 434 ? 16.181 43.255 27.271 1.00 79.91 ? 434 ARG A CD 1 ATOM 3447 N NE . ARG A 1 434 ? 15.723 41.987 27.837 1.00 85.86 ? 434 ARG A NE 1 ATOM 3448 C CZ . ARG A 1 434 ? 15.523 40.882 27.122 1.00 88.69 ? 434 ARG A CZ 1 ATOM 3449 N NH1 . ARG A 1 434 ? 15.736 40.899 25.808 1.00 90.40 ? 434 ARG A NH1 1 ATOM 3450 N NH2 . ARG A 1 434 ? 15.123 39.761 27.717 1.00 88.85 ? 434 ARG A NH2 1 ATOM 3451 N N . TYR A 1 435 ? 19.730 45.251 25.761 1.00 56.41 ? 435 TYR A N 1 ATOM 3452 C CA . TYR A 1 435 ? 20.580 45.876 24.758 1.00 52.58 ? 435 TYR A CA 1 ATOM 3453 C C . TYR A 1 435 ? 19.883 46.669 23.664 1.00 50.19 ? 435 TYR A C 1 ATOM 3454 O O . TYR A 1 435 ? 18.804 46.302 23.199 1.00 50.11 ? 435 TYR A O 1 ATOM 3455 C CB . TYR A 1 435 ? 21.447 44.803 24.104 1.00 52.80 ? 435 TYR A CB 1 ATOM 3456 C CG . TYR A 1 435 ? 22.339 44.091 25.078 1.00 54.22 ? 435 TYR A CG 1 ATOM 3457 C CD1 . TYR A 1 435 ? 23.410 44.754 25.674 1.00 54.83 ? 435 TYR A CD1 1 ATOM 3458 C CD2 . TYR A 1 435 ? 22.095 42.767 25.438 1.00 54.35 ? 435 TYR A CD2 1 ATOM 3459 C CE1 . TYR A 1 435 ? 24.219 44.122 26.607 1.00 56.02 ? 435 TYR A CE1 1 ATOM 3460 C CE2 . TYR A 1 435 ? 22.898 42.120 26.377 1.00 56.22 ? 435 TYR A CE2 1 ATOM 3461 C CZ . TYR A 1 435 ? 23.960 42.809 26.958 1.00 57.14 ? 435 TYR A CZ 1 ATOM 3462 O OH . TYR A 1 435 ? 24.758 42.199 27.902 1.00 58.62 ? 435 TYR A OH 1 ATOM 3463 N N . SER A 1 436 ? 20.524 47.761 23.260 1.00 47.06 ? 436 SER A N 1 ATOM 3464 C CA . SER A 1 436 ? 20.033 48.608 22.182 1.00 44.95 ? 436 SER A CA 1 ATOM 3465 C C . SER A 1 436 ? 21.198 48.817 21.216 1.00 43.75 ? 436 SER A C 1 ATOM 3466 O O . SER A 1 436 ? 22.349 48.941 21.645 1.00 44.58 ? 436 SER A O 1 ATOM 3467 C CB . SER A 1 436 ? 19.522 49.955 22.717 1.00 44.37 ? 436 SER A CB 1 ATOM 3468 O OG . SER A 1 436 ? 20.221 50.371 23.876 1.00 47.01 ? 436 SER A OG 1 ATOM 3469 N N . VAL A 1 437 ? 20.905 48.823 19.917 1.00 41.15 ? 437 VAL A N 1 ATOM 3470 C CA . VAL A 1 437 ? 21.936 49.012 18.896 1.00 37.13 ? 437 VAL A CA 1 ATOM 3471 C C . VAL A 1 437 ? 21.696 50.311 18.151 1.00 36.09 ? 437 VAL A C 1 ATOM 3472 O O . VAL A 1 437 ? 20.600 50.543 17.661 1.00 37.59 ? 437 VAL A O 1 ATOM 3473 C CB . VAL A 1 437 ? 21.922 47.862 17.881 1.00 35.91 ? 437 VAL A CB 1 ATOM 3474 C CG1 . VAL A 1 437 ? 22.932 48.116 16.790 1.00 34.05 ? 437 VAL A CG1 1 ATOM 3475 C CG2 . VAL A 1 437 ? 22.220 46.552 18.586 1.00 36.22 ? 437 VAL A CG2 1 ATOM 3476 N N . LEU A 1 438 ? 22.710 51.165 18.077 1.00 35.09 ? 438 LEU A N 1 ATOM 3477 C CA . LEU A 1 438 ? 22.575 52.435 17.370 1.00 36.00 ? 438 LEU A CA 1 ATOM 3478 C C . LEU A 1 438 ? 23.355 52.395 16.062 1.00 37.06 ? 438 LEU A C 1 ATOM 3479 O O . LEU A 1 438 ? 24.456 51.847 16.003 1.00 37.11 ? 438 LEU A O 1 ATOM 3480 C CB . LEU A 1 438 ? 23.097 53.594 18.220 1.00 36.15 ? 438 LEU A CB 1 ATOM 3481 C CG . LEU A 1 438 ? 23.140 54.963 17.522 1.00 36.87 ? 438 LEU A CG 1 ATOM 3482 C CD1 . LEU A 1 438 ? 21.735 55.489 17.335 1.00 37.08 ? 438 LEU A CD1 1 ATOM 3483 C CD2 . LEU A 1 438 ? 23.948 55.943 18.343 1.00 36.65 ? 438 LEU A CD2 1 ATOM 3484 N N . MET A 1 439 ? 22.779 52.971 15.013 1.00 37.60 ? 439 MET A N 1 ATOM 3485 C CA . MET A 1 439 ? 23.437 53.010 13.712 1.00 38.78 ? 439 MET A CA 1 ATOM 3486 C C . MET A 1 439 ? 23.725 54.467 13.363 1.00 39.93 ? 439 MET A C 1 ATOM 3487 O O . MET A 1 439 ? 22.860 55.325 13.520 1.00 39.37 ? 439 MET A O 1 ATOM 3488 C CB . MET A 1 439 ? 22.540 52.388 12.641 1.00 37.18 ? 439 MET A CB 1 ATOM 3489 C CG . MET A 1 439 ? 23.228 52.201 11.306 1.00 35.52 ? 439 MET A CG 1 ATOM 3490 S SD . MET A 1 439 ? 22.128 51.518 10.058 1.00 35.53 ? 439 MET A SD 1 ATOM 3491 C CE . MET A 1 439 ? 22.562 52.472 8.649 1.00 35.75 ? 439 MET A CE 1 ATOM 3492 N N . CYS A 1 440 ? 24.935 54.748 12.890 1.00 41.82 ? 440 CYS A N 1 ATOM 3493 C CA . CYS A 1 440 ? 25.296 56.116 12.546 1.00 44.27 ? 440 CYS A CA 1 ATOM 3494 C C . CYS A 1 440 ? 25.894 56.338 11.176 1.00 44.23 ? 440 CYS A C 1 ATOM 3495 O O . CYS A 1 440 ? 26.443 55.439 10.554 1.00 45.45 ? 440 CYS A O 1 ATOM 3496 C CB . CYS A 1 440 ? 26.305 56.681 13.540 1.00 47.00 ? 440 CYS A CB 1 ATOM 3497 S SG . CYS A 1 440 ? 25.722 56.948 15.235 1.00 55.13 ? 440 CYS A SG 1 ATOM 3498 N N . SER A 1 441 ? 25.786 57.580 10.731 1.00 43.81 ? 441 SER A N 1 ATOM 3499 C CA . SER A 1 441 ? 26.372 58.030 9.487 1.00 43.96 ? 441 SER A CA 1 ATOM 3500 C C . SER A 1 441 ? 27.022 59.341 9.889 1.00 44.50 ? 441 SER A C 1 ATOM 3501 O O . SER A 1 441 ? 26.376 60.387 9.897 1.00 44.65 ? 441 SER A O 1 ATOM 3502 C CB . SER A 1 441 ? 25.309 58.250 8.424 1.00 43.97 ? 441 SER A CB 1 ATOM 3503 O OG . SER A 1 441 ? 24.902 57.003 7.891 1.00 46.94 ? 441 SER A OG 1 ATOM 3504 N N . ASP A 1 442 ? 28.299 59.255 10.258 1.00 44.67 ? 442 ASP A N 1 ATOM 3505 C CA . ASP A 1 442 ? 29.077 60.404 10.707 1.00 45.15 ? 442 ASP A CA 1 ATOM 3506 C C . ASP A 1 442 ? 29.666 61.209 9.550 1.00 45.29 ? 442 ASP A C 1 ATOM 3507 O O . ASP A 1 442 ? 30.848 61.085 9.210 1.00 46.61 ? 442 ASP A O 1 ATOM 3508 C CB . ASP A 1 442 ? 30.186 59.928 11.654 1.00 46.94 ? 442 ASP A CB 1 ATOM 3509 C CG . ASP A 1 442 ? 30.934 61.074 12.297 1.00 48.98 ? 442 ASP A CG 1 ATOM 3510 O OD1 . ASP A 1 442 ? 30.259 62.045 12.716 1.00 49.60 ? 442 ASP A OD1 1 ATOM 3511 O OD2 . ASP A 1 442 ? 32.185 60.999 12.392 1.00 49.31 ? 442 ASP A OD2 1 ATOM 3512 N N . LEU A 1 443 ? 28.828 62.049 8.957 1.00 44.26 ? 443 LEU A N 1 ATOM 3513 C CA . LEU A 1 443 ? 29.229 62.879 7.832 1.00 43.38 ? 443 LEU A CA 1 ATOM 3514 C C . LEU A 1 443 ? 29.981 64.130 8.274 1.00 43.82 ? 443 LEU A C 1 ATOM 3515 O O . LEU A 1 443 ? 30.281 64.999 7.457 1.00 42.59 ? 443 LEU A O 1 ATOM 3516 C CB . LEU A 1 443 ? 27.987 63.270 7.031 1.00 40.79 ? 443 LEU A CB 1 ATOM 3517 C CG . LEU A 1 443 ? 27.380 62.228 6.080 1.00 39.61 ? 443 LEU A CG 1 ATOM 3518 C CD1 . LEU A 1 443 ? 27.575 60.832 6.614 1.00 38.10 ? 443 LEU A CD1 1 ATOM 3519 C CD2 . LEU A 1 443 ? 25.902 62.536 5.884 1.00 38.45 ? 443 LEU A CD2 1 ATOM 3520 N N . SER A 1 444 ? 30.289 64.203 9.567 1.00 44.88 ? 444 SER A N 1 ATOM 3521 C CA . SER A 1 444 ? 30.991 65.342 10.158 1.00 44.97 ? 444 SER A CA 1 ATOM 3522 C C . SER A 1 444 ? 32.353 65.609 9.534 1.00 45.62 ? 444 SER A C 1 ATOM 3523 O O . SER A 1 444 ? 32.726 66.757 9.303 1.00 46.35 ? 444 SER A O 1 ATOM 3524 C CB . SER A 1 444 ? 31.196 65.111 11.649 1.00 45.04 ? 444 SER A CB 1 ATOM 3525 O OG . SER A 1 444 ? 32.251 64.189 11.867 1.00 44.29 ? 444 SER A OG 1 ATOM 3526 N N . ARG A 1 445 ? 33.100 64.542 9.281 1.00 45.77 ? 445 ARG A N 1 ATOM 3527 C CA . ARG A 1 445 ? 34.426 64.669 8.702 1.00 46.04 ? 445 ARG A CA 1 ATOM 3528 C C . ARG A 1 445 ? 34.415 64.234 7.237 1.00 46.45 ? 445 ARG A C 1 ATOM 3529 O O . ARG A 1 445 ? 35.466 64.071 6.608 1.00 45.38 ? 445 ARG A O 1 ATOM 3530 C CB . ARG A 1 445 ? 35.402 63.803 9.491 1.00 47.37 ? 445 ARG A CB 1 ATOM 3531 C CG . ARG A 1 445 ? 36.595 64.538 10.054 1.00 50.20 ? 445 ARG A CG 1 ATOM 3532 C CD . ARG A 1 445 ? 37.558 63.559 10.700 1.00 53.32 ? 445 ARG A CD 1 ATOM 3533 N NE . ARG A 1 445 ? 36.935 62.872 11.827 1.00 57.47 ? 445 ARG A NE 1 ATOM 3534 C CZ . ARG A 1 445 ? 37.388 61.740 12.360 1.00 59.98 ? 445 ARG A CZ 1 ATOM 3535 N NH1 . ARG A 1 445 ? 38.480 61.158 11.865 1.00 60.27 ? 445 ARG A NH1 1 ATOM 3536 N NH2 . ARG A 1 445 ? 36.742 61.184 13.384 1.00 60.19 ? 445 ARG A NH2 1 ATOM 3537 N N . SER A 1 446 ? 33.214 64.055 6.699 1.00 46.34 ? 446 SER A N 1 ATOM 3538 C CA . SER A 1 446 ? 33.042 63.619 5.319 1.00 45.61 ? 446 SER A CA 1 ATOM 3539 C C . SER A 1 446 ? 33.767 64.490 4.296 1.00 45.48 ? 446 SER A C 1 ATOM 3540 O O . SER A 1 446 ? 34.250 63.976 3.288 1.00 46.43 ? 446 SER A O 1 ATOM 3541 C CB . SER A 1 446 ? 31.552 63.555 4.972 1.00 45.19 ? 446 SER A CB 1 ATOM 3542 O OG . SER A 1 446 ? 30.994 64.848 4.829 1.00 43.77 ? 446 SER A OG 1 ATOM 3543 N N . THR A 1 447 ? 33.840 65.798 4.547 1.00 45.40 ? 447 THR A N 1 ATOM 3544 C CA . THR A 1 447 ? 34.498 66.728 3.625 1.00 44.93 ? 447 THR A CA 1 ATOM 3545 C C . THR A 1 447 ? 35.149 67.911 4.325 1.00 44.38 ? 447 THR A C 1 ATOM 3546 O O . THR A 1 447 ? 34.692 68.349 5.379 1.00 43.75 ? 447 THR A O 1 ATOM 3547 C CB . THR A 1 447 ? 33.504 67.306 2.585 1.00 45.18 ? 447 THR A CB 1 ATOM 3548 O OG1 . THR A 1 447 ? 34.193 68.217 1.717 1.00 43.79 ? 447 THR A OG1 1 ATOM 3549 C CG2 . THR A 1 447 ? 32.362 68.046 3.286 1.00 43.49 ? 447 THR A CG2 1 ATOM 3550 N N . VAL A 1 448 ? 36.218 68.428 3.729 1.00 44.74 ? 448 VAL A N 1 ATOM 3551 C CA . VAL A 1 448 ? 36.914 69.576 4.291 1.00 44.37 ? 448 VAL A CA 1 ATOM 3552 C C . VAL A 1 448 ? 36.415 70.843 3.602 1.00 46.34 ? 448 VAL A C 1 ATOM 3553 O O . VAL A 1 448 ? 36.728 71.952 4.020 1.00 47.46 ? 448 VAL A O 1 ATOM 3554 C CB . VAL A 1 448 ? 38.434 69.450 4.112 1.00 40.96 ? 448 VAL A CB 1 ATOM 3555 C CG1 . VAL A 1 448 ? 38.934 68.221 4.848 1.00 38.58 ? 448 VAL A CG1 1 ATOM 3556 C CG2 . VAL A 1 448 ? 38.777 69.362 2.645 1.00 40.35 ? 448 VAL A CG2 1 ATOM 3557 N N . ARG A 1 449 ? 35.627 70.671 2.547 1.00 48.05 ? 449 ARG A N 1 ATOM 3558 C CA . ARG A 1 449 ? 35.076 71.809 1.831 1.00 50.41 ? 449 ARG A CA 1 ATOM 3559 C C . ARG A 1 449 ? 34.122 72.595 2.733 1.00 52.83 ? 449 ARG A C 1 ATOM 3560 O O . ARG A 1 449 ? 33.560 72.055 3.689 1.00 52.96 ? 449 ARG A O 1 ATOM 3561 C CB . ARG A 1 449 ? 34.324 71.342 0.585 1.00 50.22 ? 449 ARG A CB 1 ATOM 3562 C CG . ARG A 1 449 ? 35.199 70.865 -0.558 1.00 49.91 ? 449 ARG A CG 1 ATOM 3563 C CD . ARG A 1 449 ? 34.336 70.422 -1.723 1.00 48.59 ? 449 ARG A CD 1 ATOM 3564 N NE . ARG A 1 449 ? 33.339 71.431 -2.061 1.00 48.75 ? 449 ARG A NE 1 ATOM 3565 C CZ . ARG A 1 449 ? 32.304 71.213 -2.867 1.00 50.07 ? 449 ARG A CZ 1 ATOM 3566 N NH1 . ARG A 1 449 ? 32.134 70.019 -3.417 1.00 49.97 ? 449 ARG A NH1 1 ATOM 3567 N NH2 . ARG A 1 449 ? 31.435 72.185 -3.118 1.00 50.85 ? 449 ARG A NH2 1 ATOM 3568 N N . SER A 1 450 ? 33.927 73.870 2.418 1.00 55.70 ? 450 SER A N 1 ATOM 3569 C CA . SER A 1 450 ? 33.042 74.713 3.211 1.00 58.10 ? 450 SER A CA 1 ATOM 3570 C C . SER A 1 450 ? 31.674 74.873 2.570 1.00 58.25 ? 450 SER A C 1 ATOM 3571 O O . SER A 1 450 ? 31.504 74.668 1.364 1.00 58.38 ? 450 SER A O 1 ATOM 3572 C CB . SER A 1 450 ? 33.665 76.091 3.389 1.00 60.13 ? 450 SER A CB 1 ATOM 3573 O OG . SER A 1 450 ? 35.016 75.975 3.784 1.00 65.28 ? 450 SER A OG 1 ATOM 3574 N N . ASN A 1 451 ? 30.697 75.253 3.383 1.00 58.07 ? 451 ASN A N 1 ATOM 3575 C CA . ASN A 1 451 ? 29.347 75.463 2.882 1.00 58.64 ? 451 ASN A CA 1 ATOM 3576 C C . ASN A 1 451 ? 28.724 74.173 2.382 1.00 57.11 ? 451 ASN A C 1 ATOM 3577 O O . ASN A 1 451 ? 27.953 74.175 1.420 1.00 58.38 ? 451 ASN A O 1 ATOM 3578 C CB . ASN A 1 451 ? 29.361 76.499 1.759 1.00 61.22 ? 451 ASN A CB 1 ATOM 3579 C CG . ASN A 1 451 ? 29.822 77.861 2.235 1.00 64.58 ? 451 ASN A CG 1 ATOM 3580 O OD1 . ASN A 1 451 ? 30.064 78.761 1.431 1.00 66.92 ? 451 ASN A OD1 1 ATOM 3581 N ND2 . ASN A 1 451 ? 29.943 78.022 3.553 1.00 66.46 ? 451 ASN A ND2 1 ATOM 3582 N N . ILE A 1 452 ? 29.076 73.072 3.036 1.00 54.10 ? 452 ILE A N 1 ATOM 3583 C CA . ILE A 1 452 ? 28.535 71.761 2.696 1.00 49.54 ? 452 ILE A CA 1 ATOM 3584 C C . ILE A 1 452 ? 27.838 71.240 3.947 1.00 47.16 ? 452 ILE A C 1 ATOM 3585 O O . ILE A 1 452 ? 28.416 71.232 5.032 1.00 46.88 ? 452 ILE A O 1 ATOM 3586 C CB . ILE A 1 452 ? 29.648 70.776 2.290 1.00 48.89 ? 452 ILE A CB 1 ATOM 3587 C CG1 . ILE A 1 452 ? 30.494 71.375 1.167 1.00 48.18 ? 452 ILE A CG1 1 ATOM 3588 C CG2 . ILE A 1 452 ? 29.038 69.477 1.813 1.00 48.85 ? 452 ILE A CG2 1 ATOM 3589 C CD1 . ILE A 1 452 ? 29.712 71.698 -0.089 1.00 47.48 ? 452 ILE A CD1 1 ATOM 3590 N N . ASP A 1 453 ? 26.587 70.829 3.809 1.00 45.06 ? 453 ASP A N 1 ATOM 3591 C CA . ASP A 1 453 ? 25.859 70.324 4.955 1.00 42.59 ? 453 ASP A CA 1 ATOM 3592 C C . ASP A 1 453 ? 26.451 68.985 5.376 1.00 42.15 ? 453 ASP A C 1 ATOM 3593 O O . ASP A 1 453 ? 26.300 67.976 4.671 1.00 43.48 ? 453 ASP A O 1 ATOM 3594 C CB . ASP A 1 453 ? 24.388 70.147 4.614 1.00 42.40 ? 453 ASP A CB 1 ATOM 3595 C CG . ASP A 1 453 ? 23.557 69.860 5.833 1.00 45.40 ? 453 ASP A CG 1 ATOM 3596 O OD1 . ASP A 1 453 ? 24.147 69.463 6.858 1.00 47.57 ? 453 ASP A OD1 1 ATOM 3597 O OD2 . ASP A 1 453 ? 22.320 70.020 5.777 1.00 48.27 ? 453 ASP A OD2 1 ATOM 3598 N N . THR A 1 454 ? 27.129 68.972 6.521 1.00 39.24 ? 454 THR A N 1 ATOM 3599 C CA . THR A 1 454 ? 27.743 67.748 7.017 1.00 36.74 ? 454 THR A CA 1 ATOM 3600 C C . THR A 1 454 ? 27.052 67.180 8.258 1.00 36.56 ? 454 THR A C 1 ATOM 3601 O O . THR A 1 454 ? 27.695 66.588 9.132 1.00 37.33 ? 454 THR A O 1 ATOM 3602 C CB . THR A 1 454 ? 29.243 67.973 7.311 1.00 35.43 ? 454 THR A CB 1 ATOM 3603 O OG1 . THR A 1 454 ? 29.422 69.242 7.948 1.00 35.01 ? 454 THR A OG1 1 ATOM 3604 C CG2 . THR A 1 454 ? 30.042 67.954 6.025 1.00 34.38 ? 454 THR A CG2 1 ATOM 3605 N N . THR A 1 455 ? 25.737 67.347 8.334 1.00 35.27 ? 455 THR A N 1 ATOM 3606 C CA . THR A 1 455 ? 24.999 66.827 9.473 1.00 35.67 ? 455 THR A CA 1 ATOM 3607 C C . THR A 1 455 ? 25.069 65.312 9.447 1.00 35.86 ? 455 THR A C 1 ATOM 3608 O O . THR A 1 455 ? 24.991 64.703 8.379 1.00 36.58 ? 455 THR A O 1 ATOM 3609 C CB . THR A 1 455 ? 23.524 67.229 9.423 1.00 35.54 ? 455 THR A CB 1 ATOM 3610 O OG1 . THR A 1 455 ? 23.429 68.646 9.272 1.00 36.04 ? 455 THR A OG1 1 ATOM 3611 C CG2 . THR A 1 455 ? 22.817 66.820 10.709 1.00 34.90 ? 455 THR A CG2 1 ATOM 3612 N N . SER A 1 456 ? 25.229 64.704 10.614 1.00 35.64 ? 456 SER A N 1 ATOM 3613 C CA . SER A 1 456 ? 25.273 63.256 10.684 1.00 36.37 ? 456 SER A CA 1 ATOM 3614 C C . SER A 1 456 ? 23.856 62.754 10.959 1.00 36.79 ? 456 SER A C 1 ATOM 3615 O O . SER A 1 456 ? 23.034 63.472 11.538 1.00 36.69 ? 456 SER A O 1 ATOM 3616 C CB . SER A 1 456 ? 26.237 62.802 11.785 1.00 36.37 ? 456 SER A CB 1 ATOM 3617 O OG . SER A 1 456 ? 27.563 63.242 11.516 1.00 36.07 ? 456 SER A OG 1 ATOM 3618 N N . TYR A 1 457 ? 23.569 61.531 10.517 1.00 36.92 ? 457 TYR A N 1 ATOM 3619 C CA . TYR A 1 457 ? 22.252 60.923 10.707 1.00 36.69 ? 457 TYR A CA 1 ATOM 3620 C C . TYR A 1 457 ? 22.374 59.666 11.572 1.00 37.18 ? 457 TYR A C 1 ATOM 3621 O O . TYR A 1 457 ? 23.418 59.005 11.573 1.00 38.84 ? 457 TYR A O 1 ATOM 3622 C CB . TYR A 1 457 ? 21.647 60.570 9.347 1.00 35.66 ? 457 TYR A CB 1 ATOM 3623 C CG . TYR A 1 457 ? 21.634 61.737 8.401 1.00 34.83 ? 457 TYR A CG 1 ATOM 3624 C CD1 . TYR A 1 457 ? 20.803 62.821 8.627 1.00 34.31 ? 457 TYR A CD1 1 ATOM 3625 C CD2 . TYR A 1 457 ? 22.520 61.800 7.331 1.00 36.01 ? 457 TYR A CD2 1 ATOM 3626 C CE1 . TYR A 1 457 ? 20.860 63.956 7.818 1.00 36.10 ? 457 TYR A CE1 1 ATOM 3627 C CE2 . TYR A 1 457 ? 22.587 62.930 6.510 1.00 37.17 ? 457 TYR A CE2 1 ATOM 3628 C CZ . TYR A 1 457 ? 21.757 64.010 6.764 1.00 37.01 ? 457 TYR A CZ 1 ATOM 3629 O OH . TYR A 1 457 ? 21.853 65.162 6.005 1.00 37.00 ? 457 TYR A OH 1 ATOM 3630 N N . GLY A 1 458 ? 21.315 59.337 12.309 1.00 36.07 ? 458 GLY A N 1 ATOM 3631 C CA . GLY A 1 458 ? 21.364 58.159 13.157 1.00 34.78 ? 458 GLY A CA 1 ATOM 3632 C C . GLY A 1 458 ? 20.027 57.506 13.441 1.00 34.78 ? 458 GLY A C 1 ATOM 3633 O O . GLY A 1 458 ? 18.978 58.137 13.332 1.00 35.60 ? 458 GLY A O 1 ATOM 3634 N N . ALA A 1 459 ? 20.063 56.233 13.815 1.00 34.19 ? 459 ALA A N 1 ATOM 3635 C CA . ALA A 1 459 ? 18.841 55.503 14.117 1.00 34.99 ? 459 ALA A CA 1 ATOM 3636 C C . ALA A 1 459 ? 19.139 54.216 14.873 1.00 36.09 ? 459 ALA A C 1 ATOM 3637 O O . ALA A 1 459 ? 20.178 53.587 14.661 1.00 36.95 ? 459 ALA A O 1 ATOM 3638 C CB . ALA A 1 459 ? 18.103 55.189 12.833 1.00 34.52 ? 459 ALA A CB 1 ATOM 3639 N N . PHE A 1 460 ? 18.243 53.822 15.771 1.00 36.56 ? 460 PHE A N 1 ATOM 3640 C CA . PHE A 1 460 ? 18.466 52.586 16.507 1.00 37.00 ? 460 PHE A CA 1 ATOM 3641 C C . PHE A 1 460 ? 18.042 51.446 15.603 1.00 37.64 ? 460 PHE A C 1 ATOM 3642 O O . PHE A 1 460 ? 17.145 51.613 14.782 1.00 39.19 ? 460 PHE A O 1 ATOM 3643 C CB . PHE A 1 460 ? 17.675 52.580 17.812 1.00 35.30 ? 460 PHE A CB 1 ATOM 3644 C CG . PHE A 1 460 ? 18.217 53.528 18.843 1.00 36.51 ? 460 PHE A CG 1 ATOM 3645 C CD1 . PHE A 1 460 ? 17.574 54.729 19.113 1.00 36.30 ? 460 PHE A CD1 1 ATOM 3646 C CD2 . PHE A 1 460 ? 19.408 53.240 19.515 1.00 38.05 ? 460 PHE A CD2 1 ATOM 3647 C CE1 . PHE A 1 460 ? 18.104 55.637 20.046 1.00 36.41 ? 460 PHE A CE1 1 ATOM 3648 C CE2 . PHE A 1 460 ? 19.947 54.140 20.451 1.00 37.47 ? 460 PHE A CE2 1 ATOM 3649 C CZ . PHE A 1 460 ? 19.292 55.341 20.711 1.00 36.38 ? 460 PHE A CZ 1 ATOM 3650 N N . VAL A 1 461 ? 18.715 50.307 15.732 1.00 38.03 ? 461 VAL A N 1 ATOM 3651 C CA . VAL A 1 461 ? 18.421 49.135 14.916 1.00 37.59 ? 461 VAL A CA 1 ATOM 3652 C C . VAL A 1 461 ? 17.791 48.086 15.798 1.00 38.44 ? 461 VAL A C 1 ATOM 3653 O O . VAL A 1 461 ? 18.369 47.692 16.803 1.00 40.72 ? 461 VAL A O 1 ATOM 3654 C CB . VAL A 1 461 ? 19.691 48.540 14.303 1.00 36.84 ? 461 VAL A CB 1 ATOM 3655 C CG1 . VAL A 1 461 ? 19.321 47.432 13.343 1.00 35.53 ? 461 VAL A CG1 1 ATOM 3656 C CG2 . VAL A 1 461 ? 20.494 49.634 13.602 1.00 37.00 ? 461 VAL A CG2 1 ATOM 3657 N N . ASP A 1 462 ? 16.612 47.625 15.412 1.00 39.36 ? 462 ASP A N 1 ATOM 3658 C CA . ASP A 1 462 ? 15.883 46.647 16.192 1.00 40.88 ? 462 ASP A CA 1 ATOM 3659 C C . ASP A 1 462 ? 16.316 45.192 16.049 1.00 41.02 ? 462 ASP A C 1 ATOM 3660 O O . ASP A 1 462 ? 15.672 44.406 15.361 1.00 40.52 ? 462 ASP A O 1 ATOM 3661 C CB . ASP A 1 462 ? 14.396 46.771 15.887 1.00 45.72 ? 462 ASP A CB 1 ATOM 3662 C CG . ASP A 1 462 ? 13.579 45.709 16.581 1.00 51.64 ? 462 ASP A CG 1 ATOM 3663 O OD1 . ASP A 1 462 ? 13.730 45.574 17.820 1.00 53.82 ? 462 ASP A OD1 1 ATOM 3664 O OD2 . ASP A 1 462 ? 12.790 45.015 15.892 1.00 55.42 ? 462 ASP A OD2 1 ATOM 3665 N N . ILE A 1 463 ? 17.411 44.843 16.717 1.00 42.18 ? 463 ILE A N 1 ATOM 3666 C CA . ILE A 1 463 ? 17.942 43.482 16.714 1.00 42.76 ? 463 ILE A CA 1 ATOM 3667 C C . ILE A 1 463 ? 18.618 43.199 18.042 1.00 43.38 ? 463 ILE A C 1 ATOM 3668 O O . ILE A 1 463 ? 19.154 44.108 18.680 1.00 42.99 ? 463 ILE A O 1 ATOM 3669 C CB . ILE A 1 463 ? 18.999 43.258 15.618 1.00 42.98 ? 463 ILE A CB 1 ATOM 3670 C CG1 . ILE A 1 463 ? 20.137 44.268 15.769 1.00 42.77 ? 463 ILE A CG1 1 ATOM 3671 C CG2 . ILE A 1 463 ? 18.350 43.331 14.257 1.00 44.62 ? 463 ILE A CG2 1 ATOM 3672 C CD1 . ILE A 1 463 ? 21.368 43.909 14.963 1.00 44.03 ? 463 ILE A CD1 1 ATOM 3673 N N . ASP A 1 464 ? 18.594 41.934 18.453 1.00 44.92 ? 464 ASP A N 1 ATOM 3674 C CA . ASP A 1 464 ? 19.217 41.528 19.707 1.00 45.79 ? 464 ASP A CA 1 ATOM 3675 C C . ASP A 1 464 ? 20.661 41.145 19.456 1.00 45.55 ? 464 ASP A C 1 ATOM 3676 O O . ASP A 1 464 ? 20.938 40.020 19.049 1.00 45.69 ? 464 ASP A O 1 ATOM 3677 C CB . ASP A 1 464 ? 18.491 40.336 20.306 1.00 48.04 ? 464 ASP A CB 1 ATOM 3678 C CG . ASP A 1 464 ? 19.172 39.822 21.550 1.00 52.03 ? 464 ASP A CG 1 ATOM 3679 O OD1 . ASP A 1 464 ? 19.623 40.660 22.357 1.00 55.02 ? 464 ASP A OD1 1 ATOM 3680 O OD2 . ASP A 1 464 ? 19.255 38.588 21.729 1.00 55.61 ? 464 ASP A OD2 1 ATOM 3681 N N . PRO A 1 465 ? 21.604 42.067 19.721 1.00 45.26 ? 465 PRO A N 1 ATOM 3682 C CA . PRO A 1 465 ? 23.024 41.788 19.500 1.00 46.11 ? 465 PRO A CA 1 ATOM 3683 C C . PRO A 1 465 ? 23.477 40.587 20.299 1.00 47.77 ? 465 PRO A C 1 ATOM 3684 O O . PRO A 1 465 ? 24.581 40.096 20.123 1.00 49.58 ? 465 PRO A O 1 ATOM 3685 C CB . PRO A 1 465 ? 23.697 43.070 19.958 1.00 44.43 ? 465 PRO A CB 1 ATOM 3686 C CG . PRO A 1 465 ? 22.833 43.479 21.091 1.00 43.98 ? 465 PRO A CG 1 ATOM 3687 C CD . PRO A 1 465 ? 21.443 43.283 20.536 1.00 43.69 ? 465 PRO A CD 1 ATOM 3688 N N . ARG A 1 466 ? 22.600 40.111 21.167 1.00 48.89 ? 466 ARG A N 1 ATOM 3689 C CA . ARG A 1 466 ? 22.883 38.973 22.018 1.00 50.26 ? 466 ARG A CA 1 ATOM 3690 C C . ARG A 1 466 ? 22.522 37.647 21.328 1.00 49.78 ? 466 ARG A C 1 ATOM 3691 O O . ARG A 1 466 ? 22.488 36.597 21.964 1.00 51.95 ? 466 ARG A O 1 ATOM 3692 C CB . ARG A 1 466 ? 22.093 39.147 23.316 1.00 53.20 ? 466 ARG A CB 1 ATOM 3693 C CG . ARG A 1 466 ? 22.422 38.210 24.453 1.00 57.97 ? 466 ARG A CG 1 ATOM 3694 C CD . ARG A 1 466 ? 21.518 38.556 25.626 1.00 63.35 ? 466 ARG A CD 1 ATOM 3695 N NE . ARG A 1 466 ? 20.114 38.585 25.209 1.00 67.27 ? 466 ARG A NE 1 ATOM 3696 C CZ . ARG A 1 466 ? 19.243 39.535 25.544 1.00 69.94 ? 466 ARG A CZ 1 ATOM 3697 N NH1 . ARG A 1 466 ? 19.618 40.559 26.310 1.00 71.15 ? 466 ARG A NH1 1 ATOM 3698 N NH2 . ARG A 1 466 ? 17.993 39.465 25.102 1.00 69.65 ? 466 ARG A NH2 1 ATOM 3699 N N . SER A 1 467 ? 22.246 37.683 20.031 1.00 47.86 ? 467 SER A N 1 ATOM 3700 C CA . SER A 1 467 ? 21.914 36.454 19.320 1.00 46.54 ? 467 SER A CA 1 ATOM 3701 C C . SER A 1 467 ? 21.821 36.676 17.815 1.00 47.88 ? 467 SER A C 1 ATOM 3702 O O . SER A 1 467 ? 21.289 35.841 17.087 1.00 48.61 ? 467 SER A O 1 ATOM 3703 C CB . SER A 1 467 ? 20.600 35.882 19.834 1.00 44.01 ? 467 SER A CB 1 ATOM 3704 O OG . SER A 1 467 ? 19.527 36.713 19.453 1.00 44.88 ? 467 SER A OG 1 ATOM 3705 N N . GLU A 1 468 ? 22.344 37.810 17.361 1.00 49.07 ? 468 GLU A N 1 ATOM 3706 C CA . GLU A 1 468 ? 22.362 38.178 15.948 1.00 49.72 ? 468 GLU A CA 1 ATOM 3707 C C . GLU A 1 468 ? 23.626 38.978 15.695 1.00 48.71 ? 468 GLU A C 1 ATOM 3708 O O . GLU A 1 468 ? 24.027 39.784 16.537 1.00 49.39 ? 468 GLU A O 1 ATOM 3709 C CB . GLU A 1 468 ? 21.167 39.060 15.595 1.00 52.26 ? 468 GLU A CB 1 ATOM 3710 C CG . GLU A 1 468 ? 19.906 38.327 15.214 1.00 57.62 ? 468 GLU A CG 1 ATOM 3711 C CD . GLU A 1 468 ? 18.743 39.280 14.998 1.00 62.19 ? 468 GLU A CD 1 ATOM 3712 O OE1 . GLU A 1 468 ? 18.246 39.854 16.001 1.00 64.86 ? 468 GLU A OE1 1 ATOM 3713 O OE2 . GLU A 1 468 ? 18.331 39.465 13.827 1.00 63.50 ? 468 GLU A OE2 1 ATOM 3714 N N . GLU A 1 469 ? 24.268 38.748 14.557 1.00 46.31 ? 469 GLU A N 1 ATOM 3715 C CA . GLU A 1 469 ? 25.455 39.514 14.235 1.00 45.60 ? 469 GLU A CA 1 ATOM 3716 C C . GLU A 1 469 ? 24.949 40.818 13.650 1.00 45.52 ? 469 GLU A C 1 ATOM 3717 O O . GLU A 1 469 ? 24.007 40.830 12.860 1.00 47.56 ? 469 GLU A O 1 ATOM 3718 C CB . GLU A 1 469 ? 26.309 38.795 13.206 1.00 46.67 ? 469 GLU A CB 1 ATOM 3719 C CG . GLU A 1 469 ? 27.176 37.714 13.777 1.00 52.31 ? 469 GLU A CG 1 ATOM 3720 C CD . GLU A 1 469 ? 28.073 37.080 12.727 1.00 57.36 ? 469 GLU A CD 1 ATOM 3721 O OE1 . GLU A 1 469 ? 28.941 36.258 13.099 1.00 60.82 ? 469 GLU A OE1 1 ATOM 3722 O OE2 . GLU A 1 469 ? 27.914 37.399 11.527 1.00 58.72 ? 469 GLU A OE2 1 ATOM 3723 N N . ILE A 1 470 ? 25.544 41.930 14.045 1.00 43.88 ? 470 ILE A N 1 ATOM 3724 C CA . ILE A 1 470 ? 25.097 43.194 13.504 1.00 41.57 ? 470 ILE A CA 1 ATOM 3725 C C . ILE A 1 470 ? 25.646 43.236 12.093 1.00 40.44 ? 470 ILE A C 1 ATOM 3726 O O . ILE A 1 470 ? 26.853 43.125 11.898 1.00 40.66 ? 470 ILE A O 1 ATOM 3727 C CB . ILE A 1 470 ? 25.656 44.354 14.317 1.00 41.82 ? 470 ILE A CB 1 ATOM 3728 C CG1 . ILE A 1 470 ? 25.214 44.205 15.766 1.00 42.25 ? 470 ILE A CG1 1 ATOM 3729 C CG2 . ILE A 1 470 ? 25.157 45.666 13.765 1.00 40.89 ? 470 ILE A CG2 1 ATOM 3730 C CD1 . ILE A 1 470 ? 25.846 45.210 16.678 1.00 46.36 ? 470 ILE A CD1 1 ATOM 3731 N N . SER A 1 471 ? 24.770 43.366 11.108 1.00 38.85 ? 471 SER A N 1 ATOM 3732 C CA . SER A 1 471 ? 25.216 43.414 9.720 1.00 38.77 ? 471 SER A CA 1 ATOM 3733 C C . SER A 1 471 ? 24.934 44.774 9.088 1.00 37.77 ? 471 SER A C 1 ATOM 3734 O O . SER A 1 471 ? 24.030 45.495 9.511 1.00 36.58 ? 471 SER A O 1 ATOM 3735 C CB . SER A 1 471 ? 24.514 42.331 8.931 1.00 38.98 ? 471 SER A CB 1 ATOM 3736 O OG . SER A 1 471 ? 23.131 42.427 9.195 1.00 43.56 ? 471 SER A OG 1 ATOM 3737 N N . LEU A 1 472 ? 25.702 45.112 8.058 1.00 37.22 ? 472 LEU A N 1 ATOM 3738 C CA . LEU A 1 472 ? 25.552 46.395 7.378 1.00 36.79 ? 472 LEU A CA 1 ATOM 3739 C C . LEU A 1 472 ? 25.876 46.282 5.892 1.00 37.66 ? 472 LEU A C 1 ATOM 3740 O O . LEU A 1 472 ? 26.829 45.604 5.515 1.00 39.67 ? 472 LEU A O 1 ATOM 3741 C CB . LEU A 1 472 ? 26.496 47.408 8.015 1.00 34.49 ? 472 LEU A CB 1 ATOM 3742 C CG . LEU A 1 472 ? 26.617 48.764 7.345 1.00 32.94 ? 472 LEU A CG 1 ATOM 3743 C CD1 . LEU A 1 472 ? 25.362 49.550 7.634 1.00 34.31 ? 472 LEU A CD1 1 ATOM 3744 C CD2 . LEU A 1 472 ? 27.833 49.489 7.871 1.00 31.88 ? 472 LEU A CD2 1 ATOM 3745 N N . ARG A 1 473 ? 25.079 46.939 5.052 1.00 37.06 ? 473 ARG A N 1 ATOM 3746 C CA . ARG A 1 473 ? 25.316 46.929 3.611 1.00 35.21 ? 473 ARG A CA 1 ATOM 3747 C C . ARG A 1 473 ? 25.322 48.357 3.081 1.00 35.44 ? 473 ARG A C 1 ATOM 3748 O O . ARG A 1 473 ? 24.416 49.144 3.362 1.00 35.43 ? 473 ARG A O 1 ATOM 3749 C CB . ARG A 1 473 ? 24.252 46.130 2.870 1.00 32.76 ? 473 ARG A CB 1 ATOM 3750 C CG . ARG A 1 473 ? 24.576 46.007 1.401 1.00 31.28 ? 473 ARG A CG 1 ATOM 3751 C CD . ARG A 1 473 ? 23.427 45.428 0.621 1.00 30.74 ? 473 ARG A CD 1 ATOM 3752 N NE . ARG A 1 473 ? 23.706 45.445 -0.809 1.00 30.09 ? 473 ARG A NE 1 ATOM 3753 C CZ . ARG A 1 473 ? 22.811 45.137 -1.737 1.00 31.24 ? 473 ARG A CZ 1 ATOM 3754 N NH1 . ARG A 1 473 ? 21.584 44.786 -1.373 1.00 31.85 ? 473 ARG A NH1 1 ATOM 3755 N NH2 . ARG A 1 473 ? 23.134 45.189 -3.023 1.00 31.01 ? 473 ARG A NH2 1 ATOM 3756 N N . ASN A 1 474 ? 26.344 48.687 2.305 1.00 35.38 ? 474 ASN A N 1 ATOM 3757 C CA . ASN A 1 474 ? 26.477 50.027 1.762 1.00 35.48 ? 474 ASN A CA 1 ATOM 3758 C C . ASN A 1 474 ? 26.607 50.079 0.262 1.00 36.07 ? 474 ASN A C 1 ATOM 3759 O O . ASN A 1 474 ? 27.438 49.379 -0.323 1.00 37.16 ? 474 ASN A O 1 ATOM 3760 C CB . ASN A 1 474 ? 27.708 50.712 2.345 1.00 36.03 ? 474 ASN A CB 1 ATOM 3761 C CG . ASN A 1 474 ? 27.549 51.047 3.791 1.00 39.40 ? 474 ASN A CG 1 ATOM 3762 O OD1 . ASN A 1 474 ? 26.971 52.077 4.137 1.00 41.50 ? 474 ASN A OD1 1 ATOM 3763 N ND2 . ASN A 1 474 ? 28.049 50.172 4.660 1.00 42.35 ? 474 ASN A ND2 1 ATOM 3764 N N . LEU A 1 475 ? 25.781 50.917 -0.354 1.00 35.13 ? 475 LEU A N 1 ATOM 3765 C CA . LEU A 1 475 ? 25.845 51.143 -1.787 1.00 33.82 ? 475 LEU A CA 1 ATOM 3766 C C . LEU A 1 475 ? 26.609 52.465 -1.855 1.00 34.80 ? 475 LEU A C 1 ATOM 3767 O O . LEU A 1 475 ? 26.067 53.516 -1.496 1.00 36.46 ? 475 LEU A O 1 ATOM 3768 C CB . LEU A 1 475 ? 24.446 51.327 -2.373 1.00 32.04 ? 475 LEU A CB 1 ATOM 3769 C CG . LEU A 1 475 ? 23.510 50.124 -2.320 1.00 32.15 ? 475 LEU A CG 1 ATOM 3770 C CD1 . LEU A 1 475 ? 22.215 50.457 -3.034 1.00 33.01 ? 475 LEU A CD1 1 ATOM 3771 C CD2 . LEU A 1 475 ? 24.166 48.938 -2.981 1.00 33.06 ? 475 LEU A CD2 1 ATOM 3772 N N . ILE A 1 476 ? 27.872 52.410 -2.264 1.00 33.20 ? 476 ILE A N 1 ATOM 3773 C CA . ILE A 1 476 ? 28.691 53.611 -2.366 1.00 32.89 ? 476 ILE A CA 1 ATOM 3774 C C . ILE A 1 476 ? 28.745 54.048 -3.818 1.00 33.87 ? 476 ILE A C 1 ATOM 3775 O O . ILE A 1 476 ? 29.188 53.291 -4.684 1.00 34.54 ? 476 ILE A O 1 ATOM 3776 C CB . ILE A 1 476 ? 30.123 53.357 -1.893 1.00 32.97 ? 476 ILE A CB 1 ATOM 3777 C CG1 . ILE A 1 476 ? 30.111 52.843 -0.454 1.00 33.13 ? 476 ILE A CG1 1 ATOM 3778 C CG2 . ILE A 1 476 ? 30.931 54.642 -1.991 1.00 32.61 ? 476 ILE A CG2 1 ATOM 3779 C CD1 . ILE A 1 476 ? 31.480 52.430 0.060 1.00 33.04 ? 476 ILE A CD1 1 ATOM 3780 N N . ASP A 1 477 ? 28.306 55.276 -4.079 1.00 33.99 ? 477 ASP A N 1 ATOM 3781 C CA . ASP A 1 477 ? 28.282 55.805 -5.433 1.00 33.40 ? 477 ASP A CA 1 ATOM 3782 C C . ASP A 1 477 ? 28.632 57.295 -5.475 1.00 33.65 ? 477 ASP A C 1 ATOM 3783 O O . ASP A 1 477 ? 27.768 58.150 -5.624 1.00 32.89 ? 477 ASP A O 1 ATOM 3784 C CB . ASP A 1 477 ? 26.896 55.561 -6.037 1.00 33.14 ? 477 ASP A CB 1 ATOM 3785 C CG . ASP A 1 477 ? 26.902 55.602 -7.546 1.00 33.58 ? 477 ASP A CG 1 ATOM 3786 O OD1 . ASP A 1 477 ? 25.828 55.393 -8.156 1.00 32.15 ? 477 ASP A OD1 1 ATOM 3787 O OD2 . ASP A 1 477 ? 27.982 55.842 -8.122 1.00 35.22 ? 477 ASP A OD2 1 ATOM 3788 N N . HIS A 1 478 ? 29.914 57.593 -5.323 1.00 35.29 ? 478 HIS A N 1 ATOM 3789 C CA . HIS A 1 478 ? 30.416 58.962 -5.364 1.00 38.05 ? 478 HIS A CA 1 ATOM 3790 C C . HIS A 1 478 ? 29.832 59.972 -4.377 1.00 39.34 ? 478 HIS A C 1 ATOM 3791 O O . HIS A 1 478 ? 30.364 60.132 -3.279 1.00 41.41 ? 478 HIS A O 1 ATOM 3792 C CB . HIS A 1 478 ? 30.307 59.495 -6.788 1.00 39.27 ? 478 HIS A CB 1 ATOM 3793 C CG . HIS A 1 478 ? 31.095 58.696 -7.775 1.00 42.15 ? 478 HIS A CG 1 ATOM 3794 N ND1 . HIS A 1 478 ? 30.694 57.451 -8.215 1.00 42.92 ? 478 HIS A ND1 1 ATOM 3795 C CD2 . HIS A 1 478 ? 32.296 58.930 -8.355 1.00 42.36 ? 478 HIS A CD2 1 ATOM 3796 C CE1 . HIS A 1 478 ? 31.613 56.953 -9.020 1.00 42.39 ? 478 HIS A CE1 1 ATOM 3797 N NE2 . HIS A 1 478 ? 32.596 57.831 -9.121 1.00 43.71 ? 478 HIS A NE2 1 ATOM 3798 N N . SER A 1 479 ? 28.762 60.672 -4.742 1.00 38.79 ? 479 SER A N 1 ATOM 3799 C CA . SER A 1 479 ? 28.223 61.656 -3.811 1.00 37.73 ? 479 SER A CA 1 ATOM 3800 C C . SER A 1 479 ? 27.062 61.146 -2.985 1.00 37.47 ? 479 SER A C 1 ATOM 3801 O O . SER A 1 479 ? 26.402 61.933 -2.309 1.00 39.40 ? 479 SER A O 1 ATOM 3802 C CB . SER A 1 479 ? 27.807 62.944 -4.534 1.00 38.31 ? 479 SER A CB 1 ATOM 3803 O OG . SER A 1 479 ? 26.566 62.805 -5.204 1.00 39.02 ? 479 SER A OG 1 ATOM 3804 N N . ILE A 1 480 ? 26.801 59.844 -3.038 1.00 35.72 ? 480 ILE A N 1 ATOM 3805 C CA . ILE A 1 480 ? 25.721 59.275 -2.239 1.00 35.17 ? 480 ILE A CA 1 ATOM 3806 C C . ILE A 1 480 ? 26.124 57.923 -1.694 1.00 35.00 ? 480 ILE A C 1 ATOM 3807 O O . ILE A 1 480 ? 26.793 57.152 -2.374 1.00 35.72 ? 480 ILE A O 1 ATOM 3808 C CB . ILE A 1 480 ? 24.391 59.098 -3.046 1.00 34.48 ? 480 ILE A CB 1 ATOM 3809 C CG1 . ILE A 1 480 ? 23.323 58.462 -2.148 1.00 33.95 ? 480 ILE A CG1 1 ATOM 3810 C CG2 . ILE A 1 480 ? 24.606 58.201 -4.241 1.00 32.71 ? 480 ILE A CG2 1 ATOM 3811 C CD1 . ILE A 1 480 ? 21.946 58.370 -2.776 1.00 31.53 ? 480 ILE A CD1 1 ATOM 3812 N N . ILE A 1 481 ? 25.735 57.654 -0.456 1.00 34.73 ? 481 ILE A N 1 ATOM 3813 C CA . ILE A 1 481 ? 26.013 56.375 0.182 1.00 36.25 ? 481 ILE A CA 1 ATOM 3814 C C . ILE A 1 481 ? 24.706 55.954 0.822 1.00 37.28 ? 481 ILE A C 1 ATOM 3815 O O . ILE A 1 481 ? 24.114 56.725 1.577 1.00 37.94 ? 481 ILE A O 1 ATOM 3816 C CB . ILE A 1 481 ? 27.045 56.483 1.321 1.00 36.24 ? 481 ILE A CB 1 ATOM 3817 C CG1 . ILE A 1 481 ? 28.373 57.022 0.799 1.00 36.29 ? 481 ILE A CG1 1 ATOM 3818 C CG2 . ILE A 1 481 ? 27.248 55.118 1.958 1.00 35.04 ? 481 ILE A CG2 1 ATOM 3819 C CD1 . ILE A 1 481 ? 29.407 57.206 1.889 1.00 35.70 ? 481 ILE A CD1 1 ATOM 3820 N N . GLU A 1 482 ? 24.240 54.750 0.519 1.00 37.83 ? 482 GLU A N 1 ATOM 3821 C CA . GLU A 1 482 ? 23.002 54.278 1.124 1.00 38.44 ? 482 GLU A CA 1 ATOM 3822 C C . GLU A 1 482 ? 23.341 53.137 2.069 1.00 38.31 ? 482 GLU A C 1 ATOM 3823 O O . GLU A 1 482 ? 23.838 52.098 1.643 1.00 39.03 ? 482 GLU A O 1 ATOM 3824 C CB . GLU A 1 482 ? 22.028 53.816 0.049 1.00 38.83 ? 482 GLU A CB 1 ATOM 3825 C CG . GLU A 1 482 ? 21.657 54.911 -0.918 1.00 40.78 ? 482 GLU A CG 1 ATOM 3826 C CD . GLU A 1 482 ? 20.511 54.509 -1.808 1.00 43.05 ? 482 GLU A CD 1 ATOM 3827 O OE1 . GLU A 1 482 ? 19.439 54.205 -1.246 1.00 44.69 ? 482 GLU A OE1 1 ATOM 3828 O OE2 . GLU A 1 482 ? 20.679 54.492 -3.051 1.00 42.29 ? 482 GLU A OE2 1 ATOM 3829 N N . SER A 1 483 ? 23.085 53.347 3.357 1.00 37.09 ? 483 SER A N 1 ATOM 3830 C CA . SER A 1 483 ? 23.390 52.351 4.365 1.00 34.77 ? 483 SER A CA 1 ATOM 3831 C C . SER A 1 483 ? 22.175 51.569 4.825 1.00 34.91 ? 483 SER A C 1 ATOM 3832 O O . SER A 1 483 ? 21.162 52.144 5.246 1.00 33.18 ? 483 SER A O 1 ATOM 3833 C CB . SER A 1 483 ? 24.052 53.021 5.563 1.00 33.67 ? 483 SER A CB 1 ATOM 3834 O OG . SER A 1 483 ? 25.213 53.714 5.151 1.00 33.19 ? 483 SER A OG 1 ATOM 3835 N N . PHE A 1 484 ? 22.296 50.248 4.736 1.00 34.06 ? 484 PHE A N 1 ATOM 3836 C CA . PHE A 1 484 ? 21.243 49.333 5.146 1.00 34.05 ? 484 PHE A CA 1 ATOM 3837 C C . PHE A 1 484 ? 21.718 48.511 6.339 1.00 35.21 ? 484 PHE A C 1 ATOM 3838 O O . PHE A 1 484 ? 22.470 47.541 6.183 1.00 35.71 ? 484 PHE A O 1 ATOM 3839 C CB . PHE A 1 484 ? 20.883 48.393 3.998 1.00 31.65 ? 484 PHE A CB 1 ATOM 3840 C CG . PHE A 1 484 ? 20.281 49.084 2.819 1.00 28.53 ? 484 PHE A CG 1 ATOM 3841 C CD1 . PHE A 1 484 ? 18.906 49.265 2.730 1.00 28.40 ? 484 PHE A CD1 1 ATOM 3842 C CD2 . PHE A 1 484 ? 21.086 49.547 1.786 1.00 27.33 ? 484 PHE A CD2 1 ATOM 3843 C CE1 . PHE A 1 484 ? 18.334 49.903 1.620 1.00 28.54 ? 484 PHE A CE1 1 ATOM 3844 C CE2 . PHE A 1 484 ? 20.532 50.186 0.671 1.00 27.21 ? 484 PHE A CE2 1 ATOM 3845 C CZ . PHE A 1 484 ? 19.151 50.362 0.586 1.00 28.17 ? 484 PHE A CZ 1 ATOM 3846 N N . GLY A 1 485 ? 21.281 48.908 7.531 1.00 35.46 ? 485 GLY A N 1 ATOM 3847 C CA . GLY A 1 485 ? 21.658 48.185 8.730 1.00 34.23 ? 485 GLY A CA 1 ATOM 3848 C C . GLY A 1 485 ? 20.721 47.014 8.981 1.00 33.52 ? 485 GLY A C 1 ATOM 3849 O O . GLY A 1 485 ? 19.509 47.124 8.777 1.00 32.93 ? 485 GLY A O 1 ATOM 3850 N N . ALA A 1 486 ? 21.290 45.889 9.408 1.00 32.13 ? 486 ALA A N 1 ATOM 3851 C CA . ALA A 1 486 ? 20.531 44.679 9.715 1.00 31.87 ? 486 ALA A CA 1 ATOM 3852 C C . ALA A 1 486 ? 19.525 44.267 8.649 1.00 33.59 ? 486 ALA A C 1 ATOM 3853 O O . ALA A 1 486 ? 18.327 44.193 8.918 1.00 35.26 ? 486 ALA A O 1 ATOM 3854 C CB . ALA A 1 486 ? 19.818 44.835 11.048 1.00 28.88 ? 486 ALA A CB 1 ATOM 3855 N N . GLY A 1 487 ? 20.011 44.011 7.438 1.00 34.23 ? 487 GLY A N 1 ATOM 3856 C CA . GLY A 1 487 ? 19.143 43.564 6.359 1.00 33.65 ? 487 GLY A CA 1 ATOM 3857 C C . GLY A 1 487 ? 18.015 44.438 5.843 1.00 33.74 ? 487 GLY A C 1 ATOM 3858 O O . GLY A 1 487 ? 17.230 43.984 5.012 1.00 33.72 ? 487 GLY A O 1 ATOM 3859 N N . GLY A 1 488 ? 17.915 45.675 6.312 1.00 33.89 ? 488 GLY A N 1 ATOM 3860 C CA . GLY A 1 488 ? 16.858 46.534 5.819 1.00 35.02 ? 488 GLY A CA 1 ATOM 3861 C C . GLY A 1 488 ? 15.951 47.066 6.904 1.00 36.71 ? 488 GLY A C 1 ATOM 3862 O O . GLY A 1 488 ? 14.933 47.707 6.608 1.00 37.30 ? 488 GLY A O 1 ATOM 3863 N N . LYS A 1 489 ? 16.307 46.800 8.158 1.00 36.59 ? 489 LYS A N 1 ATOM 3864 C CA . LYS A 1 489 ? 15.511 47.279 9.275 1.00 36.66 ? 489 LYS A CA 1 ATOM 3865 C C . LYS A 1 489 ? 15.797 48.749 9.558 1.00 37.51 ? 489 LYS A C 1 ATOM 3866 O O . LYS A 1 489 ? 14.948 49.463 10.087 1.00 39.20 ? 489 LYS A O 1 ATOM 3867 C CB . LYS A 1 489 ? 15.801 46.473 10.529 1.00 36.63 ? 489 LYS A CB 1 ATOM 3868 C CG . LYS A 1 489 ? 15.338 45.059 10.482 1.00 38.49 ? 489 LYS A CG 1 ATOM 3869 C CD . LYS A 1 489 ? 15.322 44.508 11.884 1.00 42.12 ? 489 LYS A CD 1 ATOM 3870 C CE . LYS A 1 489 ? 14.574 43.202 11.943 1.00 44.63 ? 489 LYS A CE 1 ATOM 3871 N NZ . LYS A 1 489 ? 14.236 42.814 13.338 1.00 48.01 ? 489 LYS A NZ 1 ATOM 3872 N N . THR A 1 490 ? 17.001 49.196 9.216 1.00 36.71 ? 490 THR A N 1 ATOM 3873 C CA . THR A 1 490 ? 17.380 50.582 9.435 1.00 36.30 ? 490 THR A CA 1 ATOM 3874 C C . THR A 1 490 ? 18.181 51.084 8.234 1.00 37.08 ? 490 THR A C 1 ATOM 3875 O O . THR A 1 490 ? 19.279 50.595 7.953 1.00 36.89 ? 490 THR A O 1 ATOM 3876 C CB . THR A 1 490 ? 18.203 50.727 10.746 1.00 35.40 ? 490 THR A CB 1 ATOM 3877 O OG1 . THR A 1 490 ? 17.424 50.237 11.844 1.00 34.77 ? 490 THR A OG1 1 ATOM 3878 C CG2 . THR A 1 490 ? 18.561 52.192 11.016 1.00 34.31 ? 490 THR A CG2 1 ATOM 3879 N N . CYS A 1 491 ? 17.614 52.054 7.519 1.00 36.72 ? 491 CYS A N 1 ATOM 3880 C CA . CYS A 1 491 ? 18.256 52.624 6.338 1.00 35.80 ? 491 CYS A CA 1 ATOM 3881 C C . CYS A 1 491 ? 18.655 54.089 6.527 1.00 35.55 ? 491 CYS A C 1 ATOM 3882 O O . CYS A 1 491 ? 17.907 54.876 7.105 1.00 35.28 ? 491 CYS A O 1 ATOM 3883 C CB . CYS A 1 491 ? 17.309 52.517 5.146 1.00 35.95 ? 491 CYS A CB 1 ATOM 3884 S SG . CYS A 1 491 ? 16.695 50.847 4.834 1.00 37.06 ? 491 CYS A SG 1 ATOM 3885 N N . ILE A 1 492 ? 19.834 54.452 6.030 1.00 34.81 ? 492 ILE A N 1 ATOM 3886 C CA . ILE A 1 492 ? 20.315 55.832 6.131 1.00 33.49 ? 492 ILE A CA 1 ATOM 3887 C C . ILE A 1 492 ? 21.024 56.243 4.846 1.00 32.94 ? 492 ILE A C 1 ATOM 3888 O O . ILE A 1 492 ? 22.071 55.688 4.502 1.00 31.99 ? 492 ILE A O 1 ATOM 3889 C CB . ILE A 1 492 ? 21.310 56.016 7.291 1.00 32.48 ? 492 ILE A CB 1 ATOM 3890 C CG1 . ILE A 1 492 ? 20.653 55.631 8.616 1.00 31.23 ? 492 ILE A CG1 1 ATOM 3891 C CG2 . ILE A 1 492 ? 21.773 57.454 7.333 1.00 30.29 ? 492 ILE A CG2 1 ATOM 3892 C CD1 . ILE A 1 492 ? 21.609 55.634 9.781 1.00 31.08 ? 492 ILE A CD1 1 ATOM 3893 N N . THR A 1 493 ? 20.445 57.215 4.149 1.00 32.09 ? 493 THR A N 1 ATOM 3894 C CA . THR A 1 493 ? 21.016 57.717 2.910 1.00 31.72 ? 493 THR A CA 1 ATOM 3895 C C . THR A 1 493 ? 21.821 58.984 3.195 1.00 31.91 ? 493 THR A C 1 ATOM 3896 O O . THR A 1 493 ? 21.352 59.893 3.877 1.00 31.27 ? 493 THR A O 1 ATOM 3897 C CB . THR A 1 493 ? 19.923 58.035 1.881 1.00 30.81 ? 493 THR A CB 1 ATOM 3898 O OG1 . THR A 1 493 ? 19.129 56.862 1.648 1.00 30.64 ? 493 THR A OG1 1 ATOM 3899 C CG2 . THR A 1 493 ? 20.557 58.495 0.564 1.00 30.86 ? 493 THR A CG2 1 ATOM 3900 N N . SER A 1 494 ? 23.039 59.036 2.672 1.00 31.88 ? 494 SER A N 1 ATOM 3901 C CA . SER A 1 494 ? 23.896 60.180 2.899 1.00 32.35 ? 494 SER A CA 1 ATOM 3902 C C . SER A 1 494 ? 24.453 60.794 1.629 1.00 34.19 ? 494 SER A C 1 ATOM 3903 O O . SER A 1 494 ? 24.774 60.089 0.671 1.00 35.45 ? 494 SER A O 1 ATOM 3904 C CB . SER A 1 494 ? 25.059 59.766 3.785 1.00 30.59 ? 494 SER A CB 1 ATOM 3905 O OG . SER A 1 494 ? 24.583 59.067 4.915 1.00 32.66 ? 494 SER A OG 1 ATOM 3906 N N . ARG A 1 495 ? 24.557 62.118 1.624 1.00 34.84 ? 495 ARG A N 1 ATOM 3907 C CA . ARG A 1 495 ? 25.143 62.823 0.496 1.00 36.14 ? 495 ARG A CA 1 ATOM 3908 C C . ARG A 1 495 ? 26.449 63.410 1.018 1.00 37.84 ? 495 ARG A C 1 ATOM 3909 O O . ARG A 1 495 ? 26.451 64.168 1.995 1.00 38.29 ? 495 ARG A O 1 ATOM 3910 C CB . ARG A 1 495 ? 24.227 63.938 -0.005 1.00 34.48 ? 495 ARG A CB 1 ATOM 3911 C CG . ARG A 1 495 ? 22.947 63.453 -0.644 1.00 33.69 ? 495 ARG A CG 1 ATOM 3912 C CD . ARG A 1 495 ? 23.220 62.436 -1.750 1.00 33.17 ? 495 ARG A CD 1 ATOM 3913 N NE . ARG A 1 495 ? 24.001 62.987 -2.853 1.00 32.03 ? 495 ARG A NE 1 ATOM 3914 C CZ . ARG A 1 495 ? 23.565 63.925 -3.690 1.00 31.97 ? 495 ARG A CZ 1 ATOM 3915 N NH1 . ARG A 1 495 ? 22.342 64.423 -3.552 1.00 30.53 ? 495 ARG A NH1 1 ATOM 3916 N NH2 . ARG A 1 495 ? 24.355 64.365 -4.664 1.00 29.82 ? 495 ARG A NH2 1 ATOM 3917 N N . ILE A 1 496 ? 27.556 63.030 0.384 1.00 38.78 ? 496 ILE A N 1 ATOM 3918 C CA . ILE A 1 496 ? 28.871 63.513 0.786 1.00 39.86 ? 496 ILE A CA 1 ATOM 3919 C C . ILE A 1 496 ? 29.641 64.084 -0.404 1.00 40.77 ? 496 ILE A C 1 ATOM 3920 O O . ILE A 1 496 ? 29.591 63.545 -1.515 1.00 41.47 ? 496 ILE A O 1 ATOM 3921 C CB . ILE A 1 496 ? 29.711 62.393 1.465 1.00 38.79 ? 496 ILE A CB 1 ATOM 3922 C CG1 . ILE A 1 496 ? 30.123 61.320 0.449 1.00 37.57 ? 496 ILE A CG1 1 ATOM 3923 C CG2 . ILE A 1 496 ? 28.916 61.793 2.618 1.00 37.98 ? 496 ILE A CG2 1 ATOM 3924 C CD1 . ILE A 1 496 ? 29.006 60.431 -0.021 1.00 36.92 ? 496 ILE A CD1 1 ATOM 3925 N N . TYR A 1 497 ? 30.351 65.179 -0.160 1.00 41.02 ? 497 TYR A N 1 ATOM 3926 C CA . TYR A 1 497 ? 31.115 65.847 -1.199 1.00 41.76 ? 497 TYR A CA 1 ATOM 3927 C C . TYR A 1 497 ? 32.559 66.046 -0.754 1.00 43.20 ? 497 TYR A C 1 ATOM 3928 O O . TYR A 1 497 ? 33.015 67.174 -0.569 1.00 43.84 ? 497 TYR A O 1 ATOM 3929 C CB . TYR A 1 497 ? 30.481 67.205 -1.488 1.00 41.77 ? 497 TYR A CB 1 ATOM 3930 C CG . TYR A 1 497 ? 29.022 67.142 -1.891 1.00 41.61 ? 497 TYR A CG 1 ATOM 3931 C CD1 . TYR A 1 497 ? 28.655 67.072 -3.234 1.00 41.24 ? 497 TYR A CD1 1 ATOM 3932 C CD2 . TYR A 1 497 ? 28.006 67.182 -0.931 1.00 40.75 ? 497 TYR A CD2 1 ATOM 3933 C CE1 . TYR A 1 497 ? 27.312 67.049 -3.614 1.00 41.01 ? 497 TYR A CE1 1 ATOM 3934 C CE2 . TYR A 1 497 ? 26.659 67.161 -1.300 1.00 39.94 ? 497 TYR A CE2 1 ATOM 3935 C CZ . TYR A 1 497 ? 26.322 67.098 -2.642 1.00 41.32 ? 497 TYR A CZ 1 ATOM 3936 O OH . TYR A 1 497 ? 24.999 67.103 -3.022 1.00 41.30 ? 497 TYR A OH 1 ATOM 3937 N N . PRO A 1 498 ? 33.305 64.951 -0.569 1.00 44.13 ? 498 PRO A N 1 ATOM 3938 C CA . PRO A 1 498 ? 34.692 65.137 -0.142 1.00 44.46 ? 498 PRO A CA 1 ATOM 3939 C C . PRO A 1 498 ? 35.453 65.929 -1.196 1.00 45.77 ? 498 PRO A C 1 ATOM 3940 O O . PRO A 1 498 ? 35.047 65.976 -2.358 1.00 45.73 ? 498 PRO A O 1 ATOM 3941 C CB . PRO A 1 498 ? 35.195 63.706 0.008 1.00 44.63 ? 498 PRO A CB 1 ATOM 3942 C CG . PRO A 1 498 ? 34.427 62.976 -1.052 1.00 44.34 ? 498 PRO A CG 1 ATOM 3943 C CD . PRO A 1 498 ? 33.033 63.542 -0.899 1.00 44.22 ? 498 PRO A CD 1 ATOM 3944 N N . LYS A 1 499 ? 36.554 66.552 -0.797 1.00 47.28 ? 499 LYS A N 1 ATOM 3945 C CA . LYS A 1 499 ? 37.323 67.343 -1.740 1.00 48.79 ? 499 LYS A CA 1 ATOM 3946 C C . LYS A 1 499 ? 38.294 66.520 -2.573 1.00 49.50 ? 499 LYS A C 1 ATOM 3947 O O . LYS A 1 499 ? 38.436 66.749 -3.771 1.00 50.24 ? 499 LYS A O 1 ATOM 3948 C CB . LYS A 1 499 ? 38.104 68.443 -1.016 1.00 48.67 ? 499 LYS A CB 1 ATOM 3949 C CG . LYS A 1 499 ? 38.583 69.534 -1.965 1.00 50.52 ? 499 LYS A CG 1 ATOM 3950 C CD . LYS A 1 499 ? 39.564 70.498 -1.322 1.00 53.44 ? 499 LYS A CD 1 ATOM 3951 C CE . LYS A 1 499 ? 40.929 69.850 -1.099 1.00 56.80 ? 499 LYS A CE 1 ATOM 3952 N NZ . LYS A 1 499 ? 41.952 70.812 -0.568 1.00 58.71 ? 499 LYS A NZ 1 ATOM 3953 N N . PHE A 1 500 ? 38.952 65.553 -1.949 1.00 50.22 ? 500 PHE A N 1 ATOM 3954 C CA . PHE A 1 500 ? 39.946 64.745 -2.645 1.00 51.33 ? 500 PHE A CA 1 ATOM 3955 C C . PHE A 1 500 ? 39.496 64.121 -3.958 1.00 51.99 ? 500 PHE A C 1 ATOM 3956 O O . PHE A 1 500 ? 40.303 63.923 -4.861 1.00 52.38 ? 500 PHE A O 1 ATOM 3957 C CB . PHE A 1 500 ? 40.476 63.658 -1.709 1.00 51.78 ? 500 PHE A CB 1 ATOM 3958 C CG . PHE A 1 500 ? 39.532 62.518 -1.499 1.00 51.47 ? 500 PHE A CG 1 ATOM 3959 C CD1 . PHE A 1 500 ? 39.454 61.481 -2.431 1.00 51.56 ? 500 PHE A CD1 1 ATOM 3960 C CD2 . PHE A 1 500 ? 38.729 62.469 -0.365 1.00 51.70 ? 500 PHE A CD2 1 ATOM 3961 C CE1 . PHE A 1 500 ? 38.586 60.407 -2.238 1.00 52.34 ? 500 PHE A CE1 1 ATOM 3962 C CE2 . PHE A 1 500 ? 37.856 61.400 -0.156 1.00 53.21 ? 500 PHE A CE2 1 ATOM 3963 C CZ . PHE A 1 500 ? 37.787 60.364 -1.097 1.00 53.75 ? 500 PHE A CZ 1 ATOM 3964 N N . VAL A 1 501 ? 38.214 63.805 -4.066 1.00 53.26 ? 501 VAL A N 1 ATOM 3965 C CA . VAL A 1 501 ? 37.699 63.195 -5.282 1.00 54.25 ? 501 VAL A CA 1 ATOM 3966 C C . VAL A 1 501 ? 38.113 63.936 -6.554 1.00 55.84 ? 501 VAL A C 1 ATOM 3967 O O . VAL A 1 501 ? 38.162 63.353 -7.634 1.00 55.95 ? 501 VAL A O 1 ATOM 3968 C CB . VAL A 1 501 ? 36.175 63.106 -5.226 1.00 52.96 ? 501 VAL A CB 1 ATOM 3969 C CG1 . VAL A 1 501 ? 35.769 62.179 -4.107 1.00 52.51 ? 501 VAL A CG1 1 ATOM 3970 C CG2 . VAL A 1 501 ? 35.585 64.484 -5.008 1.00 52.71 ? 501 VAL A CG2 1 ATOM 3971 N N . ASN A 1 502 ? 38.423 65.219 -6.421 1.00 58.15 ? 502 ASN A N 1 ATOM 3972 C CA . ASN A 1 502 ? 38.821 66.024 -7.567 1.00 60.55 ? 502 ASN A CA 1 ATOM 3973 C C . ASN A 1 502 ? 40.195 65.680 -8.134 1.00 62.35 ? 502 ASN A C 1 ATOM 3974 O O . ASN A 1 502 ? 40.538 66.126 -9.230 1.00 64.15 ? 502 ASN A O 1 ATOM 3975 C CB . ASN A 1 502 ? 38.775 67.510 -7.203 1.00 60.61 ? 502 ASN A CB 1 ATOM 3976 C CG . ASN A 1 502 ? 37.362 68.059 -7.186 1.00 62.33 ? 502 ASN A CG 1 ATOM 3977 O OD1 . ASN A 1 502 ? 36.682 68.078 -8.216 1.00 63.75 ? 502 ASN A OD1 1 ATOM 3978 N ND2 . ASN A 1 502 ? 36.909 68.509 -6.016 1.00 62.51 ? 502 ASN A ND2 1 ATOM 3979 N N . ASN A 1 503 ? 40.983 64.890 -7.407 1.00 63.12 ? 503 ASN A N 1 ATOM 3980 C CA . ASN A 1 503 ? 42.314 64.528 -7.894 1.00 63.71 ? 503 ASN A CA 1 ATOM 3981 C C . ASN A 1 503 ? 42.700 63.095 -7.580 1.00 63.53 ? 503 ASN A C 1 ATOM 3982 O O . ASN A 1 503 ? 42.877 62.288 -8.491 1.00 65.48 ? 503 ASN A O 1 ATOM 3983 C CB . ASN A 1 503 ? 43.354 65.472 -7.314 1.00 64.26 ? 503 ASN A CB 1 ATOM 3984 C CG . ASN A 1 503 ? 42.726 66.662 -6.647 1.00 66.76 ? 503 ASN A CG 1 ATOM 3985 O OD1 . ASN A 1 503 ? 42.296 66.579 -5.495 1.00 67.73 ? 503 ASN A OD1 1 ATOM 3986 N ND2 . ASN A 1 503 ? 42.639 67.777 -7.374 1.00 67.53 ? 503 ASN A ND2 1 ATOM 3987 N N . GLU A 1 504 ? 42.834 62.776 -6.300 1.00 61.89 ? 504 GLU A N 1 ATOM 3988 C CA . GLU A 1 504 ? 43.200 61.424 -5.912 1.00 60.57 ? 504 GLU A CA 1 ATOM 3989 C C . GLU A 1 504 ? 41.974 60.510 -5.878 1.00 58.41 ? 504 GLU A C 1 ATOM 3990 O O . GLU A 1 504 ? 40.848 60.980 -5.999 1.00 56.92 ? 504 GLU A O 1 ATOM 3991 C CB . GLU A 1 504 ? 43.898 61.455 -4.553 1.00 63.08 ? 504 GLU A CB 1 ATOM 3992 C CG . GLU A 1 504 ? 43.078 62.057 -3.430 1.00 67.47 ? 504 GLU A CG 1 ATOM 3993 C CD . GLU A 1 504 ? 43.860 62.154 -2.125 1.00 70.74 ? 504 GLU A CD 1 ATOM 3994 O OE1 . GLU A 1 504 ? 44.764 63.015 -2.043 1.00 71.43 ? 504 GLU A OE1 1 ATOM 3995 O OE2 . GLU A 1 504 ? 43.577 61.364 -1.188 1.00 72.56 ? 504 GLU A OE2 1 ATOM 3996 N N . GLU A 1 505 ? 42.198 59.205 -5.733 1.00 57.67 ? 505 GLU A N 1 ATOM 3997 C CA . GLU A 1 505 ? 41.102 58.239 -5.684 1.00 57.40 ? 505 GLU A CA 1 ATOM 3998 C C . GLU A 1 505 ? 40.597 58.007 -4.271 1.00 55.51 ? 505 GLU A C 1 ATOM 3999 O O . GLU A 1 505 ? 41.251 58.373 -3.295 1.00 56.07 ? 505 GLU A O 1 ATOM 4000 C CB . GLU A 1 505 ? 41.524 56.900 -6.285 1.00 60.64 ? 505 GLU A CB 1 ATOM 4001 C CG . GLU A 1 505 ? 41.730 56.945 -7.788 1.00 67.24 ? 505 GLU A CG 1 ATOM 4002 C CD . GLU A 1 505 ? 41.901 55.563 -8.402 1.00 70.91 ? 505 GLU A CD 1 ATOM 4003 O OE1 . GLU A 1 505 ? 42.832 54.839 -7.975 1.00 72.44 ? 505 GLU A OE1 1 ATOM 4004 O OE2 . GLU A 1 505 ? 41.104 55.213 -9.308 1.00 72.74 ? 505 GLU A OE2 1 ATOM 4005 N N . ALA A 1 506 ? 39.428 57.388 -4.164 1.00 53.06 ? 506 ALA A N 1 ATOM 4006 C CA . ALA A 1 506 ? 38.830 57.127 -2.865 1.00 50.33 ? 506 ALA A CA 1 ATOM 4007 C C . ALA A 1 506 ? 39.274 55.788 -2.301 1.00 48.49 ? 506 ALA A C 1 ATOM 4008 O O . ALA A 1 506 ? 39.810 54.947 -3.018 1.00 47.02 ? 506 ALA A O 1 ATOM 4009 C CB . ALA A 1 506 ? 37.311 57.180 -2.974 1.00 50.63 ? 506 ALA A CB 1 ATOM 4010 N N . HIS A 1 507 ? 39.056 55.607 -1.005 1.00 47.53 ? 507 HIS A N 1 ATOM 4011 C CA . HIS A 1 507 ? 39.433 54.379 -0.330 1.00 47.25 ? 507 HIS A CA 1 ATOM 4012 C C . HIS A 1 507 ? 38.277 53.822 0.488 1.00 46.12 ? 507 HIS A C 1 ATOM 4013 O O . HIS A 1 507 ? 37.266 54.491 0.702 1.00 46.09 ? 507 HIS A O 1 ATOM 4014 C CB . HIS A 1 507 ? 40.644 54.622 0.574 1.00 49.33 ? 507 HIS A CB 1 ATOM 4015 C CG . HIS A 1 507 ? 41.916 54.890 -0.172 1.00 51.37 ? 507 HIS A CG 1 ATOM 4016 N ND1 . HIS A 1 507 ? 42.108 56.022 -0.932 1.00 52.66 ? 507 HIS A ND1 1 ATOM 4017 C CD2 . HIS A 1 507 ? 43.053 54.163 -0.286 1.00 52.10 ? 507 HIS A CD2 1 ATOM 4018 C CE1 . HIS A 1 507 ? 43.308 55.983 -1.484 1.00 52.22 ? 507 HIS A CE1 1 ATOM 4019 N NE2 . HIS A 1 507 ? 43.902 54.865 -1.108 1.00 52.22 ? 507 HIS A NE2 1 ATOM 4020 N N . LEU A 1 508 ? 38.440 52.584 0.936 1.00 43.99 ? 508 LEU A N 1 ATOM 4021 C CA . LEU A 1 508 ? 37.423 51.910 1.719 1.00 42.26 ? 508 LEU A CA 1 ATOM 4022 C C . LEU A 1 508 ? 38.079 51.283 2.947 1.00 42.31 ? 508 LEU A C 1 ATOM 4023 O O . LEU A 1 508 ? 39.044 50.530 2.828 1.00 43.49 ? 508 LEU A O 1 ATOM 4024 C CB . LEU A 1 508 ? 36.763 50.834 0.859 1.00 40.27 ? 508 LEU A CB 1 ATOM 4025 C CG . LEU A 1 508 ? 35.751 49.895 1.508 1.00 38.84 ? 508 LEU A CG 1 ATOM 4026 C CD1 . LEU A 1 508 ? 34.617 50.696 2.134 1.00 36.81 ? 508 LEU A CD1 1 ATOM 4027 C CD2 . LEU A 1 508 ? 35.233 48.933 0.450 1.00 38.15 ? 508 LEU A CD2 1 ATOM 4028 N N . PHE A 1 509 ? 37.558 51.591 4.127 1.00 40.90 ? 509 PHE A N 1 ATOM 4029 C CA . PHE A 1 509 ? 38.118 51.044 5.350 1.00 39.28 ? 509 PHE A CA 1 ATOM 4030 C C . PHE A 1 509 ? 37.068 50.452 6.274 1.00 39.77 ? 509 PHE A C 1 ATOM 4031 O O . PHE A 1 509 ? 35.911 50.883 6.292 1.00 40.20 ? 509 PHE A O 1 ATOM 4032 C CB . PHE A 1 509 ? 38.836 52.133 6.131 1.00 38.82 ? 509 PHE A CB 1 ATOM 4033 C CG . PHE A 1 509 ? 40.012 52.726 5.424 1.00 38.32 ? 509 PHE A CG 1 ATOM 4034 C CD1 . PHE A 1 509 ? 41.254 52.114 5.483 1.00 36.49 ? 509 PHE A CD1 1 ATOM 4035 C CD2 . PHE A 1 509 ? 39.893 53.943 4.754 1.00 38.08 ? 509 PHE A CD2 1 ATOM 4036 C CE1 . PHE A 1 509 ? 42.367 52.705 4.887 1.00 35.76 ? 509 PHE A CE1 1 ATOM 4037 C CE2 . PHE A 1 509 ? 40.995 54.546 4.152 1.00 35.49 ? 509 PHE A CE2 1 ATOM 4038 C CZ . PHE A 1 509 ? 42.237 53.928 4.223 1.00 34.94 ? 509 PHE A CZ 1 ATOM 4039 N N . VAL A 1 510 ? 37.490 49.455 7.042 1.00 39.37 ? 510 VAL A N 1 ATOM 4040 C CA . VAL A 1 510 ? 36.647 48.830 8.051 1.00 38.55 ? 510 VAL A CA 1 ATOM 4041 C C . VAL A 1 510 ? 37.371 49.292 9.311 1.00 38.64 ? 510 VAL A C 1 ATOM 4042 O O . VAL A 1 510 ? 38.595 49.390 9.310 1.00 38.70 ? 510 VAL A O 1 ATOM 4043 C CB . VAL A 1 510 ? 36.690 47.306 7.970 1.00 37.53 ? 510 VAL A CB 1 ATOM 4044 C CG1 . VAL A 1 510 ? 35.805 46.720 9.042 1.00 36.96 ? 510 VAL A CG1 1 ATOM 4045 C CG2 . VAL A 1 510 ? 36.241 46.848 6.603 1.00 36.60 ? 510 VAL A CG2 1 ATOM 4046 N N . PHE A 1 511 ? 36.654 49.594 10.382 1.00 38.55 ? 511 PHE A N 1 ATOM 4047 C CA . PHE A 1 511 ? 37.358 50.068 11.562 1.00 39.13 ? 511 PHE A CA 1 ATOM 4048 C C . PHE A 1 511 ? 36.639 49.778 12.861 1.00 40.05 ? 511 PHE A C 1 ATOM 4049 O O . PHE A 1 511 ? 35.445 49.487 12.878 1.00 40.01 ? 511 PHE A O 1 ATOM 4050 C CB . PHE A 1 511 ? 37.589 51.573 11.447 1.00 38.43 ? 511 PHE A CB 1 ATOM 4051 C CG . PHE A 1 511 ? 36.374 52.388 11.762 1.00 38.52 ? 511 PHE A CG 1 ATOM 4052 C CD1 . PHE A 1 511 ? 36.240 53.003 13.004 1.00 38.20 ? 511 PHE A CD1 1 ATOM 4053 C CD2 . PHE A 1 511 ? 35.335 52.499 10.840 1.00 39.03 ? 511 PHE A CD2 1 ATOM 4054 C CE1 . PHE A 1 511 ? 35.082 53.718 13.330 1.00 38.43 ? 511 PHE A CE1 1 ATOM 4055 C CE2 . PHE A 1 511 ? 34.171 53.212 11.154 1.00 39.23 ? 511 PHE A CE2 1 ATOM 4056 C CZ . PHE A 1 511 ? 34.045 53.822 12.401 1.00 38.49 ? 511 PHE A CZ 1 ATOM 4057 N N . ASN A 1 512 ? 37.387 49.870 13.953 1.00 41.84 ? 512 ASN A N 1 ATOM 4058 C CA . ASN A 1 512 ? 36.850 49.647 15.285 1.00 43.38 ? 512 ASN A CA 1 ATOM 4059 C C . ASN A 1 512 ? 37.526 50.655 16.187 1.00 44.90 ? 512 ASN A C 1 ATOM 4060 O O . ASN A 1 512 ? 38.717 50.536 16.447 1.00 45.31 ? 512 ASN A O 1 ATOM 4061 C CB . ASN A 1 512 ? 37.185 48.247 15.775 1.00 42.82 ? 512 ASN A CB 1 ATOM 4062 C CG . ASN A 1 512 ? 36.737 48.016 17.194 1.00 43.77 ? 512 ASN A CG 1 ATOM 4063 O OD1 . ASN A 1 512 ? 37.114 47.029 17.825 1.00 45.55 ? 512 ASN A OD1 1 ATOM 4064 N ND2 . ASN A 1 512 ? 35.918 48.926 17.708 1.00 45.27 ? 512 ASN A ND2 1 ATOM 4065 N N . ASN A 1 513 ? 36.782 51.654 16.653 1.00 47.26 ? 513 ASN A N 1 ATOM 4066 C CA . ASN A 1 513 ? 37.363 52.667 17.529 1.00 48.86 ? 513 ASN A CA 1 ATOM 4067 C C . ASN A 1 513 ? 36.812 52.521 18.936 1.00 49.10 ? 513 ASN A C 1 ATOM 4068 O O . ASN A 1 513 ? 36.844 53.458 19.727 1.00 49.05 ? 513 ASN A O 1 ATOM 4069 C CB . ASN A 1 513 ? 37.085 54.079 17.001 1.00 49.94 ? 513 ASN A CB 1 ATOM 4070 C CG . ASN A 1 513 ? 38.333 54.956 16.999 1.00 51.70 ? 513 ASN A CG 1 ATOM 4071 O OD1 . ASN A 1 513 ? 39.401 54.537 17.449 1.00 51.85 ? 513 ASN A OD1 1 ATOM 4072 N ND2 . ASN A 1 513 ? 38.197 56.175 16.484 1.00 52.32 ? 513 ASN A ND2 1 ATOM 4073 N N . GLY A 1 514 ? 36.293 51.337 19.237 1.00 50.05 ? 514 GLY A N 1 ATOM 4074 C CA . GLY A 1 514 ? 35.773 51.086 20.563 1.00 51.50 ? 514 GLY A CA 1 ATOM 4075 C C . GLY A 1 514 ? 36.927 50.634 21.439 1.00 52.45 ? 514 GLY A C 1 ATOM 4076 O O . GLY A 1 514 ? 38.091 50.777 21.068 1.00 51.88 ? 514 GLY A O 1 ATOM 4077 N N . THR A 1 515 ? 36.607 50.091 22.605 1.00 53.80 ? 515 THR A N 1 ATOM 4078 C CA . THR A 1 515 ? 37.627 49.605 23.521 1.00 54.62 ? 515 THR A CA 1 ATOM 4079 C C . THR A 1 515 ? 37.510 48.093 23.571 1.00 55.44 ? 515 THR A C 1 ATOM 4080 O O . THR A 1 515 ? 38.325 47.408 24.180 1.00 55.58 ? 515 THR A O 1 ATOM 4081 C CB . THR A 1 515 ? 37.427 50.175 24.928 1.00 54.00 ? 515 THR A CB 1 ATOM 4082 O OG1 . THR A 1 515 ? 36.134 49.797 25.421 1.00 54.92 ? 515 THR A OG1 1 ATOM 4083 C CG2 . THR A 1 515 ? 37.537 51.685 24.893 1.00 53.20 ? 515 THR A CG2 1 ATOM 4084 N N . GLN A 1 516 ? 36.478 47.582 22.916 1.00 56.74 ? 516 GLN A N 1 ATOM 4085 C CA . GLN A 1 516 ? 36.239 46.154 22.861 1.00 58.47 ? 516 GLN A CA 1 ATOM 4086 C C . GLN A 1 516 ? 36.606 45.638 21.483 1.00 59.08 ? 516 GLN A C 1 ATOM 4087 O O . GLN A 1 516 ? 36.757 46.411 20.537 1.00 59.94 ? 516 GLN A O 1 ATOM 4088 C CB . GLN A 1 516 ? 34.766 45.862 23.123 1.00 59.63 ? 516 GLN A CB 1 ATOM 4089 C CG . GLN A 1 516 ? 34.343 46.127 24.537 1.00 61.68 ? 516 GLN A CG 1 ATOM 4090 C CD . GLN A 1 516 ? 35.013 45.184 25.498 1.00 62.19 ? 516 GLN A CD 1 ATOM 4091 O OE1 . GLN A 1 516 ? 34.814 43.967 25.431 1.00 63.31 ? 516 GLN A OE1 1 ATOM 4092 N NE2 . GLN A 1 516 ? 35.821 45.733 26.395 1.00 61.12 ? 516 GLN A NE2 1 ATOM 4093 N N . ASN A 1 517 ? 36.750 44.326 21.372 1.00 59.01 ? 517 ASN A N 1 ATOM 4094 C CA . ASN A 1 517 ? 37.069 43.722 20.093 1.00 58.00 ? 517 ASN A CA 1 ATOM 4095 C C . ASN A 1 517 ? 35.795 43.390 19.357 1.00 56.03 ? 517 ASN A C 1 ATOM 4096 O O . ASN A 1 517 ? 34.754 43.124 19.965 1.00 55.40 ? 517 ASN A O 1 ATOM 4097 C CB . ASN A 1 517 ? 37.859 42.432 20.287 1.00 60.62 ? 517 ASN A CB 1 ATOM 4098 C CG . ASN A 1 517 ? 39.332 42.672 20.376 1.00 63.65 ? 517 ASN A CG 1 ATOM 4099 O OD1 . ASN A 1 517 ? 39.986 42.944 19.367 1.00 65.26 ? 517 ASN A OD1 1 ATOM 4100 N ND2 . ASN A 1 517 ? 39.876 42.589 21.590 1.00 65.23 ? 517 ASN A ND2 1 ATOM 4101 N N . VAL A 1 518 ? 35.886 43.423 18.038 1.00 53.48 ? 518 VAL A N 1 ATOM 4102 C CA . VAL A 1 518 ? 34.772 43.067 17.184 1.00 51.33 ? 518 VAL A CA 1 ATOM 4103 C C . VAL A 1 518 ? 35.399 42.191 16.119 1.00 49.19 ? 518 VAL A C 1 ATOM 4104 O O . VAL A 1 518 ? 36.478 42.498 15.616 1.00 48.11 ? 518 VAL A O 1 ATOM 4105 C CB . VAL A 1 518 ? 34.116 44.296 16.519 1.00 51.76 ? 518 VAL A CB 1 ATOM 4106 C CG1 . VAL A 1 518 ? 33.301 45.066 17.540 1.00 52.39 ? 518 VAL A CG1 1 ATOM 4107 C CG2 . VAL A 1 518 ? 35.181 45.186 15.907 1.00 52.62 ? 518 VAL A CG2 1 ATOM 4108 N N . LYS A 1 519 ? 34.756 41.078 15.809 1.00 47.15 ? 519 LYS A N 1 ATOM 4109 C CA . LYS A 1 519 ? 35.289 40.207 14.791 1.00 46.55 ? 519 LYS A CA 1 ATOM 4110 C C . LYS A 1 519 ? 34.408 40.309 13.566 1.00 45.79 ? 519 LYS A C 1 ATOM 4111 O O . LYS A 1 519 ? 33.181 40.288 13.663 1.00 46.17 ? 519 LYS A O 1 ATOM 4112 C CB . LYS A 1 519 ? 35.334 38.754 15.264 1.00 47.70 ? 519 LYS A CB 1 ATOM 4113 C CG . LYS A 1 519 ? 35.983 37.826 14.243 1.00 50.19 ? 519 LYS A CG 1 ATOM 4114 C CD . LYS A 1 519 ? 35.647 36.368 14.485 1.00 52.68 ? 519 LYS A CD 1 ATOM 4115 C CE . LYS A 1 519 ? 36.398 35.802 15.674 1.00 54.50 ? 519 LYS A CE 1 ATOM 4116 N NZ . LYS A 1 519 ? 35.933 34.417 15.981 1.00 56.08 ? 519 LYS A NZ 1 ATOM 4117 N N . ILE A 1 520 ? 35.043 40.456 12.412 1.00 43.86 ? 520 ILE A N 1 ATOM 4118 C CA . ILE A 1 520 ? 34.319 40.527 11.162 1.00 41.61 ? 520 ILE A CA 1 ATOM 4119 C C . ILE A 1 520 ? 34.088 39.072 10.827 1.00 40.87 ? 520 ILE A C 1 ATOM 4120 O O . ILE A 1 520 ? 35.015 38.389 10.413 1.00 40.49 ? 520 ILE A O 1 ATOM 4121 C CB . ILE A 1 520 ? 35.179 41.151 10.062 1.00 41.37 ? 520 ILE A CB 1 ATOM 4122 C CG1 . ILE A 1 520 ? 35.451 42.620 10.383 1.00 41.04 ? 520 ILE A CG1 1 ATOM 4123 C CG2 . ILE A 1 520 ? 34.483 41.016 8.730 1.00 41.78 ? 520 ILE A CG2 1 ATOM 4124 C CD1 . ILE A 1 520 ? 36.348 43.303 9.378 1.00 41.25 ? 520 ILE A CD1 1 ATOM 4125 N N . SER A 1 521 ? 32.874 38.577 11.030 1.00 40.86 ? 521 SER A N 1 ATOM 4126 C CA . SER A 1 521 ? 32.625 37.179 10.720 1.00 42.35 ? 521 SER A CA 1 ATOM 4127 C C . SER A 1 521 ? 32.813 37.045 9.223 1.00 43.97 ? 521 SER A C 1 ATOM 4128 O O . SER A 1 521 ? 33.420 36.088 8.743 1.00 44.88 ? 521 SER A O 1 ATOM 4129 C CB . SER A 1 521 ? 31.211 36.755 11.125 1.00 40.83 ? 521 SER A CB 1 ATOM 4130 O OG . SER A 1 521 ? 30.237 37.287 10.252 1.00 40.99 ? 521 SER A OG 1 ATOM 4131 N N . GLU A 1 522 ? 32.315 38.034 8.490 1.00 45.61 ? 522 GLU A N 1 ATOM 4132 C CA . GLU A 1 522 ? 32.439 38.040 7.044 1.00 47.05 ? 522 GLU A CA 1 ATOM 4133 C C . GLU A 1 522 ? 32.072 39.373 6.427 1.00 46.43 ? 522 GLU A C 1 ATOM 4134 O O . GLU A 1 522 ? 31.150 40.048 6.874 1.00 46.20 ? 522 GLU A O 1 ATOM 4135 C CB . GLU A 1 522 ? 31.567 36.958 6.432 1.00 49.59 ? 522 GLU A CB 1 ATOM 4136 C CG . GLU A 1 522 ? 31.505 37.043 4.931 1.00 55.36 ? 522 GLU A CG 1 ATOM 4137 C CD . GLU A 1 522 ? 30.952 35.787 4.319 1.00 59.76 ? 522 GLU A CD 1 ATOM 4138 O OE1 . GLU A 1 522 ? 30.034 35.186 4.936 1.00 62.09 ? 522 GLU A OE1 1 ATOM 4139 O OE2 . GLU A 1 522 ? 31.430 35.411 3.222 1.00 60.35 ? 522 GLU A OE2 1 ATOM 4140 N N . MET A 1 523 ? 32.807 39.739 5.389 1.00 46.36 ? 523 MET A N 1 ATOM 4141 C CA . MET A 1 523 ? 32.562 40.978 4.680 1.00 47.17 ? 523 MET A CA 1 ATOM 4142 C C . MET A 1 523 ? 32.827 40.749 3.200 1.00 47.56 ? 523 MET A C 1 ATOM 4143 O O . MET A 1 523 ? 33.816 40.110 2.842 1.00 49.28 ? 523 MET A O 1 ATOM 4144 C CB . MET A 1 523 ? 33.485 42.077 5.196 1.00 48.03 ? 523 MET A CB 1 ATOM 4145 C CG . MET A 1 523 ? 33.288 43.413 4.503 1.00 50.14 ? 523 MET A CG 1 ATOM 4146 S SD . MET A 1 523 ? 34.781 43.981 3.685 1.00 53.94 ? 523 MET A SD 1 ATOM 4147 C CE . MET A 1 523 ? 34.525 43.356 2.032 1.00 52.46 ? 523 MET A CE 1 ATOM 4148 N N . SER A 1 524 ? 31.944 41.251 2.339 1.00 46.29 ? 524 SER A N 1 ATOM 4149 C CA . SER A 1 524 ? 32.132 41.098 0.902 1.00 45.26 ? 524 SER A CA 1 ATOM 4150 C C . SER A 1 524 ? 31.884 42.412 0.181 1.00 44.22 ? 524 SER A C 1 ATOM 4151 O O . SER A 1 524 ? 30.873 43.075 0.397 1.00 43.73 ? 524 SER A O 1 ATOM 4152 C CB . SER A 1 524 ? 31.213 40.009 0.350 1.00 44.29 ? 524 SER A CB 1 ATOM 4153 O OG . SER A 1 524 ? 29.875 40.255 0.724 1.00 47.11 ? 524 SER A OG 1 ATOM 4154 N N . ALA A 1 525 ? 32.830 42.780 -0.673 1.00 44.23 ? 525 ALA A N 1 ATOM 4155 C CA . ALA A 1 525 ? 32.753 44.013 -1.444 1.00 44.22 ? 525 ALA A CA 1 ATOM 4156 C C . ALA A 1 525 ? 32.884 43.732 -2.940 1.00 44.40 ? 525 ALA A C 1 ATOM 4157 O O . ALA A 1 525 ? 33.680 42.889 -3.359 1.00 45.85 ? 525 ALA A O 1 ATOM 4158 C CB . ALA A 1 525 ? 33.855 44.969 -1.001 1.00 42.30 ? 525 ALA A CB 1 ATOM 4159 N N . TRP A 1 526 ? 32.092 44.434 -3.742 1.00 43.00 ? 526 TRP A N 1 ATOM 4160 C CA . TRP A 1 526 ? 32.151 44.279 -5.188 1.00 41.88 ? 526 TRP A CA 1 ATOM 4161 C C . TRP A 1 526 ? 32.316 45.655 -5.807 1.00 41.56 ? 526 TRP A C 1 ATOM 4162 O O . TRP A 1 526 ? 31.784 46.641 -5.296 1.00 41.15 ? 526 TRP A O 1 ATOM 4163 C CB . TRP A 1 526 ? 30.860 43.679 -5.737 1.00 41.20 ? 526 TRP A CB 1 ATOM 4164 C CG . TRP A 1 526 ? 30.551 42.302 -5.298 1.00 39.44 ? 526 TRP A CG 1 ATOM 4165 C CD1 . TRP A 1 526 ? 30.860 41.144 -5.942 1.00 38.70 ? 526 TRP A CD1 1 ATOM 4166 C CD2 . TRP A 1 526 ? 29.785 41.938 -4.158 1.00 39.10 ? 526 TRP A CD2 1 ATOM 4167 N NE1 . TRP A 1 526 ? 30.320 40.075 -5.277 1.00 37.13 ? 526 TRP A NE1 1 ATOM 4168 C CE2 . TRP A 1 526 ? 29.652 40.538 -4.174 1.00 38.38 ? 526 TRP A CE2 1 ATOM 4169 C CE3 . TRP A 1 526 ? 29.189 42.664 -3.119 1.00 40.96 ? 526 TRP A CE3 1 ATOM 4170 C CZ2 . TRP A 1 526 ? 28.946 39.846 -3.193 1.00 40.34 ? 526 TRP A CZ2 1 ATOM 4171 C CZ3 . TRP A 1 526 ? 28.484 41.978 -2.138 1.00 41.06 ? 526 TRP A CZ3 1 ATOM 4172 C CH2 . TRP A 1 526 ? 28.368 40.582 -2.184 1.00 41.51 ? 526 TRP A CH2 1 ATOM 4173 N N . SER A 1 527 ? 33.061 45.727 -6.901 1.00 41.03 ? 527 SER A N 1 ATOM 4174 C CA . SER A 1 527 ? 33.223 46.994 -7.586 1.00 40.86 ? 527 SER A CA 1 ATOM 4175 C C . SER A 1 527 ? 32.015 47.037 -8.510 1.00 40.98 ? 527 SER A C 1 ATOM 4176 O O . SER A 1 527 ? 31.768 46.092 -9.254 1.00 41.00 ? 527 SER A O 1 ATOM 4177 C CB . SER A 1 527 ? 34.528 47.020 -8.383 1.00 40.23 ? 527 SER A CB 1 ATOM 4178 O OG . SER A 1 527 ? 35.648 46.997 -7.512 1.00 39.28 ? 527 SER A OG 1 ATOM 4179 N N . MET A 1 528 ? 31.247 48.116 -8.441 1.00 41.74 ? 528 MET A N 1 ATOM 4180 C CA . MET A 1 528 ? 30.049 48.247 -9.264 1.00 42.99 ? 528 MET A CA 1 ATOM 4181 C C . MET A 1 528 ? 30.297 48.931 -10.603 1.00 43.71 ? 528 MET A C 1 ATOM 4182 O O . MET A 1 528 ? 30.833 50.043 -10.644 1.00 43.38 ? 528 MET A O 1 ATOM 4183 C CB . MET A 1 528 ? 28.984 49.032 -8.502 1.00 42.75 ? 528 MET A CB 1 ATOM 4184 C CG . MET A 1 528 ? 28.578 48.398 -7.204 1.00 41.85 ? 528 MET A CG 1 ATOM 4185 S SD . MET A 1 528 ? 27.845 46.811 -7.506 1.00 42.50 ? 528 MET A SD 1 ATOM 4186 C CE . MET A 1 528 ? 26.139 47.285 -7.742 1.00 43.34 ? 528 MET A CE 1 ATOM 4187 N N . LYS A 1 529 ? 29.898 48.277 -11.693 1.00 43.81 ? 529 LYS A N 1 ATOM 4188 C CA . LYS A 1 529 ? 30.072 48.866 -13.016 1.00 45.12 ? 529 LYS A CA 1 ATOM 4189 C C . LYS A 1 529 ? 28.966 49.881 -13.255 1.00 45.72 ? 529 LYS A C 1 ATOM 4190 O O . LYS A 1 529 ? 27.920 49.812 -12.616 1.00 47.88 ? 529 LYS A O 1 ATOM 4191 C CB . LYS A 1 529 ? 30.049 47.796 -14.109 1.00 45.32 ? 529 LYS A CB 1 ATOM 4192 C CG . LYS A 1 529 ? 28.801 46.961 -14.171 1.00 47.63 ? 529 LYS A CG 1 ATOM 4193 C CD . LYS A 1 529 ? 28.731 46.234 -15.502 1.00 51.89 ? 529 LYS A CD 1 ATOM 4194 C CE . LYS A 1 529 ? 28.555 47.235 -16.645 1.00 57.28 ? 529 LYS A CE 1 ATOM 4195 N NZ . LYS A 1 529 ? 28.358 46.599 -17.991 1.00 61.51 ? 529 LYS A NZ 1 ATOM 4196 N N . ASN A 1 530 ? 29.196 50.822 -14.167 1.00 45.51 ? 530 ASN A N 1 ATOM 4197 C CA . ASN A 1 530 ? 28.208 51.856 -14.454 1.00 44.86 ? 530 ASN A CA 1 ATOM 4198 C C . ASN A 1 530 ? 26.893 51.365 -15.018 1.00 45.76 ? 530 ASN A C 1 ATOM 4199 O O . ASN A 1 530 ? 26.823 50.324 -15.682 1.00 46.83 ? 530 ASN A O 1 ATOM 4200 C CB . ASN A 1 530 ? 28.771 52.885 -15.425 1.00 42.66 ? 530 ASN A CB 1 ATOM 4201 C CG . ASN A 1 530 ? 29.789 53.767 -14.790 1.00 41.88 ? 530 ASN A CG 1 ATOM 4202 O OD1 . ASN A 1 530 ? 30.003 54.892 -15.217 1.00 43.47 ? 530 ASN A OD1 1 ATOM 4203 N ND2 . ASN A 1 530 ? 30.438 53.262 -13.759 1.00 43.29 ? 530 ASN A ND2 1 ATOM 4204 N N . ALA A 1 531 ? 25.847 52.134 -14.744 1.00 45.54 ? 531 ALA A N 1 ATOM 4205 C CA . ALA A 1 531 ? 24.526 51.830 -15.261 1.00 46.60 ? 531 ALA A CA 1 ATOM 4206 C C . ALA A 1 531 ? 24.513 52.460 -16.655 1.00 47.25 ? 531 ALA A C 1 ATOM 4207 O O . ALA A 1 531 ? 25.307 53.365 -16.929 1.00 47.40 ? 531 ALA A O 1 ATOM 4208 C CB . ALA A 1 531 ? 23.465 52.466 -14.378 1.00 46.24 ? 531 ALA A CB 1 ATOM 4209 N N . LYS A 1 532 ? 23.652 51.977 -17.546 1.00 47.71 ? 532 LYS A N 1 ATOM 4210 C CA . LYS A 1 532 ? 23.583 52.551 -18.889 1.00 47.83 ? 532 LYS A CA 1 ATOM 4211 C C . LYS A 1 532 ? 22.427 53.531 -18.988 1.00 46.54 ? 532 LYS A C 1 ATOM 4212 O O . LYS A 1 532 ? 21.286 53.203 -18.667 1.00 46.34 ? 532 LYS A O 1 ATOM 4213 C CB . LYS A 1 532 ? 23.445 51.453 -19.954 1.00 49.32 ? 532 LYS A CB 1 ATOM 4214 C CG . LYS A 1 532 ? 24.744 50.706 -20.210 1.00 54.11 ? 532 LYS A CG 1 ATOM 4215 C CD . LYS A 1 532 ? 24.549 49.435 -21.043 1.00 59.43 ? 532 LYS A CD 1 ATOM 4216 C CE . LYS A 1 532 ? 25.826 48.565 -21.035 1.00 61.45 ? 532 LYS A CE 1 ATOM 4217 N NZ . LYS A 1 532 ? 25.672 47.255 -21.747 1.00 61.81 ? 532 LYS A NZ 1 ATOM 4218 N N . PHE A 1 533 ? 22.741 54.746 -19.415 1.00 45.61 ? 533 PHE A N 1 ATOM 4219 C CA . PHE A 1 533 ? 21.744 55.793 -19.573 1.00 45.47 ? 533 PHE A CA 1 ATOM 4220 C C . PHE A 1 533 ? 21.812 56.336 -20.990 1.00 46.96 ? 533 PHE A C 1 ATOM 4221 O O . PHE A 1 533 ? 22.580 57.254 -21.260 1.00 47.50 ? 533 PHE A O 1 ATOM 4222 C CB . PHE A 1 533 ? 22.006 56.939 -18.594 1.00 41.18 ? 533 PHE A CB 1 ATOM 4223 C CG . PHE A 1 533 ? 21.825 56.563 -17.161 1.00 39.15 ? 533 PHE A CG 1 ATOM 4224 C CD1 . PHE A 1 533 ? 20.559 56.572 -16.582 1.00 39.13 ? 533 PHE A CD1 1 ATOM 4225 C CD2 . PHE A 1 533 ? 22.917 56.196 -16.383 1.00 38.12 ? 533 PHE A CD2 1 ATOM 4226 C CE1 . PHE A 1 533 ? 20.379 56.210 -15.247 1.00 38.08 ? 533 PHE A CE1 1 ATOM 4227 C CE2 . PHE A 1 533 ? 22.754 55.830 -15.043 1.00 36.99 ? 533 PHE A CE2 1 ATOM 4228 C CZ . PHE A 1 533 ? 21.484 55.842 -14.477 1.00 37.82 ? 533 PHE A CZ 1 ATOM 4229 N N . VAL A 1 534 ? 21.028 55.772 -21.901 1.00 48.32 ? 534 VAL A N 1 ATOM 4230 C CA . VAL A 1 534 ? 21.029 56.272 -23.267 1.00 50.46 ? 534 VAL A CA 1 ATOM 4231 C C . VAL A 1 534 ? 20.027 57.421 -23.354 1.00 53.16 ? 534 VAL A C 1 ATOM 4232 O O . VAL A 1 534 ? 18.953 57.362 -22.755 1.00 54.25 ? 534 VAL A O 1 ATOM 4233 C CB . VAL A 1 534 ? 20.627 55.184 -24.266 1.00 48.80 ? 534 VAL A CB 1 ATOM 4234 C CG1 . VAL A 1 534 ? 21.616 54.046 -24.211 1.00 48.67 ? 534 VAL A CG1 1 ATOM 4235 C CG2 . VAL A 1 534 ? 19.241 54.690 -23.955 1.00 48.60 ? 534 VAL A CG2 1 ATOM 4236 N N . VAL A 1 535 ? 20.377 58.470 -24.089 1.00 55.04 ? 535 VAL A N 1 ATOM 4237 C CA . VAL A 1 535 ? 19.481 59.606 -24.220 1.00 57.25 ? 535 VAL A CA 1 ATOM 4238 C C . VAL A 1 535 ? 18.782 59.638 -25.567 1.00 60.68 ? 535 VAL A C 1 ATOM 4239 O O . VAL A 1 535 ? 19.417 59.762 -26.613 1.00 61.74 ? 535 VAL A O 1 ATOM 4240 C CB . VAL A 1 535 ? 20.229 60.927 -24.022 1.00 55.24 ? 535 VAL A CB 1 ATOM 4241 C CG1 . VAL A 1 535 ? 19.285 62.096 -24.242 1.00 53.68 ? 535 VAL A CG1 1 ATOM 4242 C CG2 . VAL A 1 535 ? 20.811 60.972 -22.629 1.00 54.27 ? 535 VAL A CG2 1 ATOM 4243 N N . ASP A 1 536 ? 17.462 59.522 -25.528 1.00 63.76 ? 536 ASP A N 1 ATOM 4244 C CA . ASP A 1 536 ? 16.644 59.548 -26.727 1.00 68.04 ? 536 ASP A CA 1 ATOM 4245 C C . ASP A 1 536 ? 15.687 60.726 -26.560 1.00 71.58 ? 536 ASP A C 1 ATOM 4246 O O . ASP A 1 536 ? 14.567 60.553 -26.085 1.00 73.92 ? 536 ASP A O 1 ATOM 4247 C CB . ASP A 1 536 ? 15.857 58.244 -26.832 1.00 67.88 ? 536 ASP A CB 1 ATOM 4248 C CG . ASP A 1 536 ? 14.950 58.205 -28.043 1.00 69.76 ? 536 ASP A CG 1 ATOM 4249 O OD1 . ASP A 1 536 ? 14.065 57.321 -28.082 1.00 70.35 ? 536 ASP A OD1 1 ATOM 4250 O OD2 . ASP A 1 536 ? 15.123 59.049 -28.956 1.00 70.40 ? 536 ASP A OD2 1 ATOM 4251 N N . GLN A 1 537 ? 16.118 61.924 -26.948 1.00 74.10 ? 537 GLN A N 1 ATOM 4252 C CA . GLN A 1 537 ? 15.268 63.097 -26.781 1.00 76.11 ? 537 GLN A CA 1 ATOM 4253 C C . GLN A 1 537 ? 15.059 63.987 -28.005 1.00 78.05 ? 537 GLN A C 1 ATOM 4254 O O . GLN A 1 537 ? 14.324 63.621 -28.928 1.00 78.62 ? 537 GLN A O 1 ATOM 4255 C CB . GLN A 1 537 ? 15.796 63.935 -25.618 1.00 75.81 ? 537 GLN A CB 1 ATOM 4256 C CG . GLN A 1 537 ? 15.585 63.281 -24.266 1.00 76.69 ? 537 GLN A CG 1 ATOM 4257 C CD . GLN A 1 537 ? 16.383 63.942 -23.162 1.00 77.70 ? 537 GLN A CD 1 ATOM 4258 O OE1 . GLN A 1 537 ? 16.126 63.719 -21.979 1.00 77.62 ? 537 GLN A OE1 1 ATOM 4259 N NE2 . GLN A 1 537 ? 17.368 64.751 -23.543 1.00 78.35 ? 537 GLN A NE2 1 ATOM 4260 N N . SER A 1 538 ? 15.699 65.158 -27.996 1.00 79.69 ? 538 SER A N 1 ATOM 4261 C CA . SER A 1 538 ? 15.587 66.146 -29.074 1.00 80.47 ? 538 SER A CA 1 ATOM 4262 C C . SER A 1 538 ? 14.270 66.908 -28.950 1.00 80.26 ? 538 SER A C 1 ATOM 4263 O O . SER A 1 538 ? 14.325 68.122 -28.662 1.00 80.38 ? 538 SER A O 1 ATOM 4264 C CB . SER A 1 538 ? 15.668 65.476 -30.455 1.00 81.60 ? 538 SER A CB 1 ATOM 4265 O OG . SER A 1 538 ? 16.977 65.001 -30.732 1.00 82.89 ? 538 SER A OG 1 HETATM 4266 C C1 . NAG B 2 . ? 39.259 57.152 16.620 1.00 53.55 ? 650 NAG A C1 1 HETATM 4267 C C2 . NAG B 2 . ? 39.249 58.091 15.419 1.00 55.49 ? 650 NAG A C2 1 HETATM 4268 C C3 . NAG B 2 . ? 40.374 59.119 15.565 1.00 56.63 ? 650 NAG A C3 1 HETATM 4269 C C4 . NAG B 2 . ? 40.189 59.875 16.880 1.00 58.24 ? 650 NAG A C4 1 HETATM 4270 C C5 . NAG B 2 . ? 40.139 58.872 18.037 1.00 56.73 ? 650 NAG A C5 1 HETATM 4271 C C6 . NAG B 2 . ? 39.867 59.525 19.383 1.00 57.36 ? 650 NAG A C6 1 HETATM 4272 C C7 . NAG B 2 . ? 38.761 57.716 13.100 1.00 59.55 ? 650 NAG A C7 1 HETATM 4273 C C8 . NAG B 2 . ? 39.587 58.418 12.032 1.00 59.72 ? 650 NAG A C8 1 HETATM 4274 N N2 . NAG B 2 . ? 39.400 57.328 14.198 1.00 57.76 ? 650 NAG A N2 1 HETATM 4275 O O3 . NAG B 2 . ? 40.373 60.023 14.464 1.00 54.36 ? 650 NAG A O3 1 HETATM 4276 O O4 . NAG B 2 . ? 41.273 60.811 17.082 1.00 63.03 ? 650 NAG A O4 1 HETATM 4277 O O5 . NAG B 2 . ? 39.093 57.902 17.824 1.00 54.97 ? 650 NAG A O5 1 HETATM 4278 O O6 . NAG B 2 . ? 39.651 60.923 19.251 1.00 59.29 ? 650 NAG A O6 1 HETATM 4279 O O7 . NAG B 2 . ? 37.554 57.544 12.938 1.00 59.66 ? 650 NAG A O7 1 HETATM 4280 C C1 . NDG C 3 . ? 41.234 61.982 16.336 1.00 68.16 ? 660 NDG A C1 1 HETATM 4281 C C2 . NDG C 3 . ? 42.626 62.560 16.182 1.00 69.23 ? 660 NDG A C2 1 HETATM 4282 C C3 . NDG C 3 . ? 42.498 63.697 15.161 1.00 71.77 ? 660 NDG A C3 1 HETATM 4283 C C4 . NDG C 3 . ? 41.505 64.771 15.671 1.00 72.24 ? 660 NDG A C4 1 HETATM 4284 C C5 . NDG C 3 . ? 40.180 64.148 16.185 1.00 72.87 ? 660 NDG A C5 1 HETATM 4285 C C6 . NDG C 3 . ? 39.238 63.767 15.057 1.00 74.16 ? 660 NDG A C6 1 HETATM 4286 C C7 . NDG C 3 . ? 43.131 62.318 18.550 1.00 63.90 ? 660 NDG A C7 1 HETATM 4287 C C8 . NDG C 3 . ? 42.181 62.647 19.693 1.00 62.81 ? 660 NDG A C8 1 HETATM 4288 O O . NDG C 3 . ? 40.410 62.955 16.999 1.00 71.35 ? 660 NDG A O 1 HETATM 4289 O O3 . NDG C 3 . ? 42.039 63.172 13.916 1.00 70.79 ? 660 NDG A O3 1 HETATM 4290 O O4 . NDG C 3 . ? 42.097 65.559 16.696 1.00 72.14 ? 660 NDG A O4 1 HETATM 4291 O O6 . NDG C 3 . ? 37.885 63.936 15.453 1.00 77.02 ? 660 NDG A O6 1 HETATM 4292 O O7 . NDG C 3 . ? 43.900 61.367 18.653 1.00 61.42 ? 660 NDG A O7 1 HETATM 4293 N N2 . NDG C 3 . ? 43.083 63.087 17.463 1.00 66.32 ? 660 NDG A N2 1 HETATM 4294 C C1 . NAG D 2 . ? 2.533 57.691 -31.127 1.00 71.75 ? 680 NAG A C1 1 HETATM 4295 C C2 . NAG D 2 . ? 3.344 57.665 -32.431 1.00 73.27 ? 680 NAG A C2 1 HETATM 4296 C C3 . NAG D 2 . ? 3.968 59.043 -32.685 1.00 74.29 ? 680 NAG A C3 1 HETATM 4297 C C4 . NAG D 2 . ? 2.883 60.112 -32.843 1.00 75.39 ? 680 NAG A C4 1 HETATM 4298 C C5 . NAG D 2 . ? 1.785 59.935 -31.776 1.00 74.55 ? 680 NAG A C5 1 HETATM 4299 C C6 . NAG D 2 . ? 0.457 59.423 -32.295 1.00 75.20 ? 680 NAG A C6 1 HETATM 4300 C C7 . NAG D 2 . ? 4.118 55.376 -32.227 1.00 72.63 ? 680 NAG A C7 1 HETATM 4301 C C8 . NAG D 2 . ? 3.504 54.680 -33.438 1.00 71.27 ? 680 NAG A C8 1 HETATM 4302 N N2 . NAG D 2 . ? 4.403 56.674 -32.327 1.00 73.18 ? 680 NAG A N2 1 HETATM 4303 O O3 . NAG D 2 . ? 4.771 59.000 -33.858 1.00 75.59 ? 680 NAG A O3 1 HETATM 4304 O O4 . NAG D 2 . ? 3.481 61.435 -32.736 1.00 77.25 ? 680 NAG A O4 1 HETATM 4305 O O5 . NAG D 2 . ? 2.207 59.041 -30.709 1.00 74.16 ? 680 NAG A O5 1 HETATM 4306 O O6 . NAG D 2 . ? -0.571 59.639 -31.335 1.00 76.12 ? 680 NAG A O6 1 HETATM 4307 O O7 . NAG D 2 . ? 4.350 54.730 -31.213 1.00 72.99 ? 680 NAG A O7 1 HETATM 4308 C C1 . NAG E 2 . ? 3.482 62.252 -33.873 1.00 78.33 ? 690 NAG A C1 1 HETATM 4309 C C2 . NAG E 2 . ? 3.800 63.710 -33.505 1.00 77.99 ? 690 NAG A C2 1 HETATM 4310 C C3 . NAG E 2 . ? 3.834 64.558 -34.778 1.00 79.01 ? 690 NAG A C3 1 HETATM 4311 C C4 . NAG E 2 . ? 4.870 63.998 -35.757 1.00 80.70 ? 690 NAG A C4 1 HETATM 4312 C C5 . NAG E 2 . ? 4.508 62.529 -36.029 1.00 80.01 ? 690 NAG A C5 1 HETATM 4313 C C6 . NAG E 2 . ? 5.506 61.842 -36.927 1.00 80.54 ? 690 NAG A C6 1 HETATM 4314 C C7 . NAG E 2 . ? 2.970 64.068 -31.276 1.00 76.20 ? 690 NAG A C7 1 HETATM 4315 C C8 . NAG E 2 . ? 3.922 65.007 -30.551 1.00 75.86 ? 690 NAG A C8 1 HETATM 4316 N N2 . NAG E 2 . ? 2.817 64.243 -32.584 1.00 76.81 ? 690 NAG A N2 1 HETATM 4317 O O3 . NAG E 2 . ? 4.128 65.911 -34.457 1.00 78.36 ? 690 NAG A O3 1 HETATM 4318 O O4 . NAG E 2 . ? 4.845 64.758 -36.997 1.00 83.79 ? 690 NAG A O4 1 HETATM 4319 O O5 . NAG E 2 . ? 4.468 61.767 -34.795 1.00 78.75 ? 690 NAG A O5 1 HETATM 4320 O O6 . NAG E 2 . ? 6.686 61.536 -36.203 1.00 81.63 ? 690 NAG A O6 1 HETATM 4321 O O7 . NAG E 2 . ? 2.379 63.193 -30.654 1.00 75.95 ? 690 NAG A O7 1 HETATM 4322 C C1 . BMA F 4 . ? 5.761 65.793 -37.173 1.00 87.23 ? 700 BMA A C1 1 HETATM 4323 C C2 . BMA F 4 . ? 7.096 65.241 -37.714 1.00 89.06 ? 700 BMA A C2 1 HETATM 4324 C C3 . BMA F 4 . ? 7.545 65.963 -39.006 1.00 91.37 ? 700 BMA A C3 1 HETATM 4325 C C4 . BMA F 4 . ? 7.442 67.480 -38.836 1.00 92.54 ? 700 BMA A C4 1 HETATM 4326 C C5 . BMA F 4 . ? 6.050 67.889 -38.294 1.00 91.79 ? 700 BMA A C5 1 HETATM 4327 C C6 . BMA F 4 . ? 5.329 68.843 -39.236 1.00 90.75 ? 700 BMA A C6 1 HETATM 4328 O O2 . BMA F 4 . ? 6.984 63.847 -37.963 1.00 90.07 ? 700 BMA A O2 1 HETATM 4329 O O3 . BMA F 4 . ? 6.758 65.548 -40.152 1.00 91.34 ? 700 BMA A O3 1 HETATM 4330 O O4 . BMA F 4 . ? 8.464 67.939 -37.954 1.00 93.64 ? 700 BMA A O4 1 HETATM 4331 O O5 . BMA F 4 . ? 5.199 66.729 -38.106 1.00 89.17 ? 700 BMA A O5 1 HETATM 4332 O O6 . BMA F 4 . ? 6.196 69.889 -39.673 1.00 88.33 ? 700 BMA A O6 1 HETATM 4333 C C1 . BMA G 4 . ? 7.370 65.823 -41.389 1.00 91.05 ? 710 BMA A C1 1 HETATM 4334 C C2 . BMA G 4 . ? 7.574 64.539 -42.196 1.00 90.72 ? 710 BMA A C2 1 HETATM 4335 C C3 . BMA G 4 . ? 7.944 64.885 -43.627 1.00 91.19 ? 710 BMA A C3 1 HETATM 4336 C C4 . BMA G 4 . ? 6.760 65.608 -44.296 1.00 92.13 ? 710 BMA A C4 1 HETATM 4337 C C5 . BMA G 4 . ? 6.010 66.585 -43.351 1.00 91.14 ? 710 BMA A C5 1 HETATM 4338 C C6 . BMA G 4 . ? 4.577 66.206 -42.977 1.00 90.05 ? 710 BMA A C6 1 HETATM 4339 O O2 . BMA G 4 . ? 6.390 63.749 -42.166 1.00 89.83 ? 710 BMA A O2 1 HETATM 4340 O O3 . BMA G 4 . ? 8.266 63.688 -44.335 1.00 89.93 ? 710 BMA A O3 1 HETATM 4341 O O4 . BMA G 4 . ? 7.213 66.325 -45.444 1.00 92.31 ? 710 BMA A O4 1 HETATM 4342 O O5 . BMA G 4 . ? 6.751 66.902 -42.130 1.00 91.65 ? 710 BMA A O5 1 HETATM 4343 O O6 . BMA G 4 . ? 4.516 65.338 -41.853 1.00 89.03 ? 710 BMA A O6 1 HETATM 4344 C C1 . DQR H 5 . ? 9.070 73.606 -3.559 1.00 76.30 ? 801 DQR A C1 1 HETATM 4345 C C10 . DQR H 5 . ? 6.583 71.719 -3.682 1.00 66.18 ? 801 DQR A C10 1 HETATM 4346 C C11 . DQR H 5 . ? 8.033 68.646 -2.100 1.00 53.90 ? 801 DQR A C11 1 HETATM 4347 C C2 . DQR H 5 . ? 10.373 73.038 -2.969 1.00 78.23 ? 801 DQR A C2 1 HETATM 4348 C C20 . DQR H 5 . ? 6.692 73.122 -3.081 1.00 69.50 ? 801 DQR A C20 1 HETATM 4349 C C21 . DQR H 5 . ? 7.138 69.281 -3.154 1.00 54.37 ? 801 DQR A C21 1 HETATM 4350 C C3 . DQR H 5 . ? 10.990 73.992 -1.953 1.00 80.51 ? 801 DQR A C3 1 HETATM 4351 C C30 . DQR H 5 . ? 5.715 73.182 -1.913 1.00 70.18 ? 801 DQR A C30 1 HETATM 4352 C C31 . DQR H 5 . ? 5.784 68.528 -3.356 1.00 51.90 ? 801 DQR A C31 1 HETATM 4353 C C4 . DQR H 5 . ? 11.218 75.366 -2.581 1.00 79.70 ? 801 DQR A C4 1 HETATM 4354 C C40 . DQR H 5 . ? 4.864 74.397 -2.243 1.00 72.07 ? 801 DQR A C40 1 HETATM 4355 C C41 . DQR H 5 . ? 5.441 68.795 -4.799 1.00 50.80 ? 801 DQR A C41 1 HETATM 4356 C C5 . DQR H 5 . ? 9.853 75.908 -3.058 1.00 78.37 ? 801 DQR A C5 1 HETATM 4357 C C50 . DQR H 5 . ? 5.008 74.593 -3.768 1.00 73.35 ? 801 DQR A C50 1 HETATM 4358 C C51 . DQR H 5 . ? 6.816 68.866 -5.500 1.00 51.26 ? 801 DQR A C51 1 HETATM 4359 C C6 . DQR H 5 . ? 9.961 77.269 -3.709 1.00 77.50 ? 801 DQR A C6 1 HETATM 4360 C C60 . DQR H 5 . ? 5.042 76.035 -4.199 1.00 76.12 ? 801 DQR A C60 1 HETATM 4361 C C61 . DQR H 5 . ? 6.908 69.927 -6.586 1.00 49.77 ? 801 DQR A C61 1 HETATM 4362 O O1 . DQR H 5 . ? 8.002 73.510 -2.616 1.00 71.85 ? 801 DQR A O1 1 HETATM 4363 O O10 . DQR H 5 . ? 6.952 70.679 -2.721 1.00 59.81 ? 801 DQR A O10 1 HETATM 4364 O O11 . DQR H 5 . ? 8.304 67.279 -2.361 1.00 53.33 ? 801 DQR A O11 1 HETATM 4365 O O2 . DQR H 5 . ? 10.137 71.729 -2.461 1.00 79.74 ? 801 DQR A O2 1 HETATM 4366 O O20 . DQR H 5 . ? 6.245 73.956 -4.128 1.00 70.64 ? 801 DQR A O20 1 HETATM 4367 O O21 . DQR H 5 . ? 7.778 69.168 -4.429 1.00 52.91 ? 801 DQR A O21 1 HETATM 4368 O O3 . DQR H 5 . ? 12.209 73.391 -1.489 1.00 82.93 ? 801 DQR A O3 1 HETATM 4369 O O30 . DQR H 5 . ? 6.382 73.364 -0.664 1.00 69.50 ? 801 DQR A O30 1 HETATM 4370 O O31 . DQR H 5 . ? 4.731 68.972 -2.516 1.00 50.15 ? 801 DQR A O31 1 HETATM 4371 O O4 . DQR H 5 . ? 11.806 76.263 -1.630 1.00 81.25 ? 801 DQR A O4 1 HETATM 4372 O O40 . DQR H 5 . ? 3.513 74.211 -1.818 1.00 72.57 ? 801 DQR A O40 1 HETATM 4373 O O41 . DQR H 5 . ? 4.563 67.804 -5.316 1.00 51.21 ? 801 DQR A O41 1 HETATM 4374 O O5 . DQR H 5 . ? 9.278 74.957 -4.043 1.00 77.40 ? 801 DQR A O5 1 HETATM 4375 O O60 . DQR H 5 . ? 5.191 76.071 -5.616 1.00 78.62 ? 801 DQR A O60 1 HETATM 4376 O O61 . DQR H 5 . ? 8.211 69.923 -7.159 1.00 47.20 ? 801 DQR A O61 1 HETATM 4377 O O6 . DQR H 5 . ? 8.371 77.719 -4.152 1.00 76.48 ? 801 DQR A O6 1 HETATM 4378 O O . HOH I 6 . ? 6.325 55.748 -0.086 1.00 17.99 ? 1001 HOH A O 1 HETATM 4379 O O . HOH I 6 . ? 36.113 75.577 0.602 1.00 17.09 ? 1002 HOH A O 1 HETATM 4380 O O . HOH I 6 . ? 25.545 61.785 26.652 1.00 7.71 ? 1003 HOH A O 1 HETATM 4381 O O . HOH I 6 . ? 14.717 60.819 6.681 1.00 30.34 ? 1004 HOH A O 1 HETATM 4382 O O . HOH I 6 . ? -5.737 46.500 6.471 1.00 23.77 ? 1005 HOH A O 1 HETATM 4383 O O . HOH I 6 . ? 29.956 66.765 -10.189 1.00 26.36 ? 1006 HOH A O 1 HETATM 4384 O O . HOH I 6 . ? 35.815 71.816 -9.939 1.00 37.55 ? 1007 HOH A O 1 HETATM 4385 O O . HOH I 6 . ? 17.524 40.923 3.522 1.00 23.82 ? 1008 HOH A O 1 HETATM 4386 O O . HOH I 6 . ? 21.004 40.184 -1.510 1.00 37.71 ? 1009 HOH A O 1 HETATM 4387 O O . HOH I 6 . ? 34.190 62.799 14.429 1.00 16.63 ? 1010 HOH A O 1 HETATM 4388 O O . HOH I 6 . ? 3.864 35.868 10.355 1.00 32.84 ? 1011 HOH A O 1 HETATM 4389 O O . HOH I 6 . ? -1.069 54.416 -3.077 1.00 29.68 ? 1012 HOH A O 1 HETATM 4390 O O . HOH I 6 . ? 8.983 39.004 -5.005 1.00 23.47 ? 1013 HOH A O 1 HETATM 4391 O O . HOH I 6 . ? -7.625 57.246 10.289 1.00 32.81 ? 1014 HOH A O 1 HETATM 4392 O O . HOH I 6 . ? 14.596 70.138 2.103 1.00 34.45 ? 1015 HOH A O 1 HETATM 4393 O O . HOH I 6 . ? 31.613 55.545 -12.813 1.00 27.59 ? 1016 HOH A O 1 HETATM 4394 O O . HOH I 6 . ? 14.789 53.657 -3.398 1.00 36.50 ? 1017 HOH A O 1 HETATM 4395 O O . HOH I 6 . ? -10.465 76.250 -0.693 1.00 34.40 ? 1018 HOH A O 1 HETATM 4396 O O . HOH I 6 . ? -4.727 57.351 11.515 1.00 33.48 ? 1019 HOH A O 1 HETATM 4397 O O . HOH I 6 . ? 26.719 58.615 25.395 1.00 26.02 ? 1020 HOH A O 1 HETATM 4398 O O . HOH I 6 . ? 8.584 34.978 1.046 1.00 29.91 ? 1021 HOH A O 1 HETATM 4399 O O . HOH I 6 . ? 2.759 48.838 14.195 1.00 34.46 ? 1022 HOH A O 1 HETATM 4400 O O . HOH I 6 . ? -6.930 55.813 -23.979 1.00 38.69 ? 1023 HOH A O 1 HETATM 4401 O O . HOH I 6 . ? 28.365 52.500 31.347 1.00 39.65 ? 1024 HOH A O 1 HETATM 4402 O O . HOH I 6 . ? -12.920 71.220 -13.527 1.00 31.07 ? 1025 HOH A O 1 HETATM 4403 O O . HOH I 6 . ? 16.033 57.971 27.850 1.00 52.75 ? 1026 HOH A O 1 HETATM 4404 O O . HOH I 6 . ? 30.212 72.061 7.518 1.00 37.29 ? 1027 HOH A O 1 HETATM 4405 O O . HOH I 6 . ? 44.603 60.788 13.565 1.00 54.64 ? 1028 HOH A O 1 HETATM 4406 O O . HOH I 6 . ? -4.785 49.131 -8.178 1.00 39.39 ? 1029 HOH A O 1 HETATM 4407 O O . HOH I 6 . ? 7.799 36.696 6.486 1.00 35.15 ? 1030 HOH A O 1 HETATM 4408 O O . HOH I 6 . ? 47.155 55.209 -3.218 1.00 47.44 ? 1031 HOH A O 1 HETATM 4409 O O . HOH I 6 . ? -14.628 56.316 8.741 1.00 36.90 ? 1032 HOH A O 1 HETATM 4410 O O . HOH I 6 . ? -6.241 47.692 -11.240 1.00 39.64 ? 1033 HOH A O 1 HETATM 4411 O O . HOH I 6 . ? 11.152 44.180 -17.736 1.00 43.93 ? 1034 HOH A O 1 HETATM 4412 O O . HOH I 6 . ? -12.812 53.624 -14.151 1.00 37.09 ? 1035 HOH A O 1 HETATM 4413 O O . HOH I 6 . ? 0.927 46.047 -17.784 1.00 44.66 ? 1036 HOH A O 1 HETATM 4414 O O . HOH I 6 . ? -12.557 75.861 -9.683 1.00 43.15 ? 1037 HOH A O 1 HETATM 4415 O O . HOH I 6 . ? 26.637 56.086 -15.734 1.00 22.99 ? 1038 HOH A O 1 HETATM 4416 O O . HOH I 6 . ? -2.674 50.672 -9.938 1.00 51.66 ? 1039 HOH A O 1 HETATM 4417 O O . HOH I 6 . ? 17.842 53.202 -10.912 1.00 12.65 ? 1040 HOH A O 1 HETATM 4418 O O . HOH I 6 . ? 35.595 74.494 -2.055 1.00 20.41 ? 1041 HOH A O 1 HETATM 4419 O O . HOH I 6 . ? 23.653 45.639 -19.888 1.00 34.91 ? 1042 HOH A O 1 HETATM 4420 O O . HOH I 6 . ? 20.156 52.855 -12.128 1.00 34.40 ? 1043 HOH A O 1 HETATM 4421 O O . HOH I 6 . ? 3.084 44.370 -17.026 1.00 34.24 ? 1044 HOH A O 1 HETATM 4422 O O . HOH I 6 . ? 3.539 37.822 12.071 1.00 50.26 ? 1045 HOH A O 1 HETATM 4423 O O . HOH I 6 . ? 37.653 64.964 18.675 1.00 40.17 ? 1046 HOH A O 1 HETATM 4424 O O . HOH I 6 . ? 5.035 50.599 -21.288 1.00 29.94 ? 1047 HOH A O 1 HETATM 4425 O O . HOH I 6 . ? 4.213 64.206 -23.896 1.00 44.60 ? 1048 HOH A O 1 HETATM 4426 O O . HOH I 6 . ? 36.849 72.620 -4.492 1.00 42.07 ? 1049 HOH A O 1 HETATM 4427 O O . HOH I 6 . ? 11.135 37.832 -2.424 1.00 39.83 ? 1050 HOH A O 1 HETATM 4428 O O . HOH I 6 . ? 7.664 45.998 20.954 1.00 57.40 ? 1051 HOH A O 1 HETATM 4429 O O . HOH I 6 . ? -5.634 61.932 17.759 1.00 24.00 ? 1052 HOH A O 1 HETATM 4430 O O . HOH I 6 . ? -4.387 80.876 -4.735 1.00 46.26 ? 1053 HOH A O 1 HETATM 4431 O O . HOH I 6 . ? 31.869 74.935 -1.180 1.00 38.39 ? 1054 HOH A O 1 HETATM 4432 O O . HOH I 6 . ? 43.659 51.728 22.204 1.00 40.00 ? 1055 HOH A O 1 HETATM 4433 O O . HOH I 6 . ? 31.930 73.511 -6.854 1.00 33.00 ? 1056 HOH A O 1 HETATM 4434 O O . HOH I 6 . ? 9.283 46.274 23.670 1.00 45.45 ? 1057 HOH A O 1 HETATM 4435 O O . HOH I 6 . ? 21.701 34.063 13.535 1.00 40.57 ? 1058 HOH A O 1 HETATM 4436 O O . HOH I 6 . ? 13.412 39.618 -1.308 1.00 20.97 ? 1059 HOH A O 1 HETATM 4437 O O . HOH I 6 . ? 24.438 57.738 -13.112 1.00 39.35 ? 1060 HOH A O 1 HETATM 4438 O O . HOH I 6 . ? 24.899 56.319 4.873 1.00 29.97 ? 1061 HOH A O 1 HETATM 4439 O O . HOH I 6 . ? 17.189 66.710 10.726 1.00 25.52 ? 1062 HOH A O 1 HETATM 4440 O O . HOH I 6 . ? 18.504 51.855 -2.289 1.00 31.87 ? 1063 HOH A O 1 HETATM 4441 O O . HOH I 6 . ? 24.053 64.103 3.379 1.00 35.77 ? 1064 HOH A O 1 HETATM 4442 O O . HOH I 6 . ? 18.189 55.111 -8.653 1.00 23.56 ? 1065 HOH A O 1 HETATM 4443 O O . HOH I 6 . ? -7.030 44.809 -10.509 1.00 23.80 ? 1066 HOH A O 1 HETATM 4444 O O . HOH I 6 . ? 22.630 69.302 14.604 1.00 45.34 ? 1067 HOH A O 1 HETATM 4445 O O . HOH I 6 . ? 33.367 33.133 16.908 1.00 40.79 ? 1068 HOH A O 1 HETATM 4446 O O . HOH I 6 . ? 34.514 72.283 -7.202 1.00 31.17 ? 1069 HOH A O 1 HETATM 4447 O O . HOH I 6 . ? 31.236 75.725 6.403 1.00 36.78 ? 1070 HOH A O 1 HETATM 4448 O O . HOH I 6 . ? 13.319 52.046 11.147 1.00 31.93 ? 1071 HOH A O 1 HETATM 4449 O O . HOH I 6 . ? 21.689 47.231 -21.249 1.00 56.57 ? 1072 HOH A O 1 HETATM 4450 O O . HOH I 6 . ? 37.482 42.345 -13.302 1.00 40.58 ? 1073 HOH A O 1 HETATM 4451 O O . HOH I 6 . ? 43.087 44.162 2.969 1.00 30.21 ? 1074 HOH A O 1 HETATM 4452 O O . HOH I 6 . ? 26.392 37.750 0.334 1.00 46.64 ? 1075 HOH A O 1 HETATM 4453 O O . HOH I 6 . ? 20.529 43.812 -3.666 1.00 32.69 ? 1076 HOH A O 1 HETATM 4454 O O . HOH I 6 . ? 11.177 51.731 9.025 1.00 29.65 ? 1077 HOH A O 1 HETATM 4455 O O . HOH I 6 . ? 19.074 66.951 -18.330 1.00 35.24 ? 1078 HOH A O 1 HETATM 4456 O O . HOH I 6 . ? 23.317 77.057 -0.392 1.00 43.91 ? 1079 HOH A O 1 HETATM 4457 O O . HOH I 6 . ? 27.522 40.670 -12.711 1.00 47.13 ? 1080 HOH A O 1 HETATM 4458 O O . HOH I 6 . ? 43.987 64.293 1.265 1.00 41.84 ? 1081 HOH A O 1 HETATM 4459 O O . HOH I 6 . ? 1.764 67.341 -21.596 1.00 35.98 ? 1082 HOH A O 1 HETATM 4460 O O . HOH I 6 . ? 24.406 65.994 5.750 1.00 23.06 ? 1083 HOH A O 1 HETATM 4461 O O . HOH I 6 . ? 11.928 58.691 5.506 1.00 31.67 ? 1084 HOH A O 1 HETATM 4462 O O . HOH I 6 . ? 7.200 75.012 -9.991 1.00 39.95 ? 1085 HOH A O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 GLN 1 1 ? ? ? A . n A 1 2 GLN 2 2 ? ? ? A . n A 1 3 ILE 3 3 3 ILE ILE A . n A 1 4 GLU 4 4 4 GLU GLU A . n A 1 5 GLN 5 5 5 GLN GLN A . n A 1 6 PRO 6 6 6 PRO PRO A . n A 1 7 TYR 7 7 7 TYR TYR A . n A 1 8 ARG 8 8 8 ARG ARG A . n A 1 9 THR 9 9 9 THR THR A . n A 1 10 GLY 10 10 10 GLY GLY A . n A 1 11 TYR 11 11 11 TYR TYR A . n A 1 12 HIS 12 12 12 HIS HIS A . n A 1 13 PHE 13 13 13 PHE PHE A . n A 1 14 GLN 14 14 14 GLN GLN A . n A 1 15 PRO 15 15 15 PRO PRO A . n A 1 16 PRO 16 16 16 PRO PRO A . n A 1 17 SER 17 17 17 SER SER A . n A 1 18 ASN 18 18 18 ASN ASN A . n A 1 19 TRP 19 19 19 TRP TRP A . n A 1 20 MET 20 20 20 MET MET A . n A 1 21 ASN 21 21 21 ASN ASN A . n A 1 22 ASP 22 22 22 ASP ASP A . n A 1 23 PRO 23 23 23 PRO PRO A . n A 1 24 ASN 24 24 24 ASN ASN A . n A 1 25 GLY 25 25 25 GLY GLY A . n A 1 26 PRO 26 26 26 PRO PRO A . n A 1 27 MET 27 27 27 MET MET A . n A 1 28 LEU 28 28 28 LEU LEU A . n A 1 29 TYR 29 29 29 TYR TYR A . n A 1 30 GLN 30 30 30 GLN GLN A . n A 1 31 GLY 31 31 31 GLY GLY A . n A 1 32 VAL 32 32 32 VAL VAL A . n A 1 33 TYR 33 33 33 TYR TYR A . n A 1 34 HIS 34 34 34 HIS HIS A . n A 1 35 PHE 35 35 35 PHE PHE A . n A 1 36 PHE 36 36 36 PHE PHE A . n A 1 37 TYR 37 37 37 TYR TYR A . n A 1 38 GLN 38 38 38 GLN GLN A . n A 1 39 TYR 39 39 39 TYR TYR A . n A 1 40 ASN 40 40 40 ASN ASN A . n A 1 41 PRO 41 41 41 PRO PRO A . n A 1 42 TYR 42 42 42 TYR TYR A . n A 1 43 ALA 43 43 43 ALA ALA A . n A 1 44 ALA 44 44 44 ALA ALA A . n A 1 45 THR 45 45 45 THR THR A . n A 1 46 PHE 46 46 46 PHE PHE A . n A 1 47 GLY 47 47 47 GLY GLY A . n A 1 48 ASP 48 48 48 ASP ASP A . n A 1 49 VAL 49 49 49 VAL VAL A . n A 1 50 ILE 50 50 50 ILE ILE A . n A 1 51 ILE 51 51 51 ILE ILE A . n A 1 52 TRP 52 52 52 TRP TRP A . n A 1 53 GLY 53 53 53 GLY GLY A . n A 1 54 HIS 54 54 54 HIS HIS A . n A 1 55 ALA 55 55 55 ALA ALA A . n A 1 56 VAL 56 56 56 VAL VAL A . n A 1 57 SER 57 57 57 SER SER A . n A 1 58 TYR 58 58 58 TYR TYR A . n A 1 59 ASP 59 59 59 ASP ASP A . n A 1 60 LEU 60 60 60 LEU LEU A . n A 1 61 VAL 61 61 61 VAL VAL A . n A 1 62 ASN 62 62 62 ASN ASN A . n A 1 63 TRP 63 63 63 TRP TRP A . n A 1 64 ILE 64 64 64 ILE ILE A . n A 1 65 HIS 65 65 65 HIS HIS A . n A 1 66 LEU 66 66 66 LEU LEU A . n A 1 67 ASP 67 67 67 ASP ASP A . n A 1 68 PRO 68 68 68 PRO PRO A . n A 1 69 ALA 69 69 69 ALA ALA A . n A 1 70 ILE 70 70 70 ILE ILE A . n A 1 71 TYR 71 71 71 TYR TYR A . n A 1 72 PRO 72 72 72 PRO PRO A . n A 1 73 THR 73 73 73 THR THR A . n A 1 74 GLN 74 74 74 GLN GLN A . n A 1 75 GLU 75 75 75 GLU GLU A . n A 1 76 ALA 76 76 76 ALA ALA A . n A 1 77 ASP 77 77 77 ASP ASP A . n A 1 78 SER 78 78 78 SER SER A . n A 1 79 LYS 79 79 79 LYS LYS A . n A 1 80 SER 80 80 80 SER SER A . n A 1 81 CYS 81 81 81 CYS CYS A . n A 1 82 TRP 82 82 82 TRP TRP A . n A 1 83 SER 83 83 83 SER SER A . n A 1 84 GLY 84 84 84 GLY GLY A . n A 1 85 SER 85 85 85 SER SER A . n A 1 86 ALA 86 86 86 ALA ALA A . n A 1 87 THR 87 87 87 THR THR A . n A 1 88 ILE 88 88 88 ILE ILE A . n A 1 89 LEU 89 89 89 LEU LEU A . n A 1 90 PRO 90 90 90 PRO PRO A . n A 1 91 GLY 91 91 91 GLY GLY A . n A 1 92 ASN 92 92 92 ASN ASN A . n A 1 93 ILE 93 93 93 ILE ILE A . n A 1 94 PRO 94 94 94 PRO PRO A . n A 1 95 ALA 95 95 95 ALA ALA A . n A 1 96 MET 96 96 96 MET MET A . n A 1 97 LEU 97 97 97 LEU LEU A . n A 1 98 TYR 98 98 98 TYR TYR A . n A 1 99 THR 99 99 99 THR THR A . n A 1 100 GLY 100 100 100 GLY GLY A . n A 1 101 SER 101 101 101 SER SER A . n A 1 102 ASP 102 102 102 ASP ASP A . n A 1 103 SER 103 103 103 SER SER A . n A 1 104 LYS 104 104 104 LYS LYS A . n A 1 105 SER 105 105 105 SER SER A . n A 1 106 ARG 106 106 106 ARG ARG A . n A 1 107 GLN 107 107 107 GLN GLN A . n A 1 108 VAL 108 108 108 VAL VAL A . n A 1 109 GLN 109 109 109 GLN GLN A . n A 1 110 ASP 110 110 110 ASP ASP A . n A 1 111 LEU 111 111 111 LEU LEU A . n A 1 112 ALA 112 112 112 ALA ALA A . n A 1 113 TRP 113 113 113 TRP TRP A . n A 1 114 PRO 114 114 114 PRO PRO A . n A 1 115 LYS 115 115 115 LYS LYS A . n A 1 116 ASN 116 116 116 ASN ASN A . n A 1 117 LEU 117 117 117 LEU LEU A . n A 1 118 SER 118 118 118 SER SER A . n A 1 119 ASP 119 119 119 ASP ASP A . n A 1 120 PRO 120 120 120 PRO PRO A . n A 1 121 PHE 121 121 121 PHE PHE A . n A 1 122 LEU 122 122 122 LEU LEU A . n A 1 123 ARG 123 123 123 ARG ARG A . n A 1 124 GLU 124 124 124 GLU GLU A . n A 1 125 TRP 125 125 125 TRP TRP A . n A 1 126 VAL 126 126 126 VAL VAL A . n A 1 127 LYS 127 127 127 LYS LYS A . n A 1 128 HIS 128 128 128 HIS HIS A . n A 1 129 PRO 129 129 129 PRO PRO A . n A 1 130 LYS 130 130 130 LYS LYS A . n A 1 131 ASN 131 131 131 ASN ASN A . n A 1 132 PRO 132 132 132 PRO PRO A . n A 1 133 LEU 133 133 133 LEU LEU A . n A 1 134 ILE 134 134 134 ILE ILE A . n A 1 135 THR 135 135 135 THR THR A . n A 1 136 PRO 136 136 136 PRO PRO A . n A 1 137 PRO 137 137 137 PRO PRO A . n A 1 138 GLU 138 138 138 GLU GLU A . n A 1 139 GLY 139 139 139 GLY GLY A . n A 1 140 VAL 140 140 140 VAL VAL A . n A 1 141 LYS 141 141 141 LYS LYS A . n A 1 142 ASP 142 142 142 ASP ASP A . n A 1 143 ASP 143 143 143 ASP ASP A . n A 1 144 CYS 144 144 144 CYS CYS A . n A 1 145 PHE 145 145 145 PHE PHE A . n A 1 146 ARG 146 146 146 ARG ARG A . n A 1 147 ASP 147 147 147 ASP ASP A . n A 1 148 PRO 148 148 148 PRO PRO A . n A 1 149 SER 149 149 149 SER SER A . n A 1 150 THR 150 150 150 THR THR A . n A 1 151 ALA 151 151 151 ALA ALA A . n A 1 152 TRP 152 152 152 TRP TRP A . n A 1 153 LEU 153 153 153 LEU LEU A . n A 1 154 GLY 154 154 154 GLY GLY A . n A 1 155 PRO 155 155 155 PRO PRO A . n A 1 156 ASP 156 156 156 ASP ASP A . n A 1 157 GLY 157 157 157 GLY GLY A . n A 1 158 VAL 158 158 158 VAL VAL A . n A 1 159 TRP 159 159 159 TRP TRP A . n A 1 160 ARG 160 160 160 ARG ARG A . n A 1 161 ILE 161 161 161 ILE ILE A . n A 1 162 VAL 162 162 162 VAL VAL A . n A 1 163 VAL 163 163 163 VAL VAL A . n A 1 164 GLY 164 164 164 GLY GLY A . n A 1 165 GLY 165 165 165 GLY GLY A . n A 1 166 ASP 166 166 166 ASP ASP A . n A 1 167 ARG 167 167 167 ARG ARG A . n A 1 168 ASP 168 168 168 ASP ASP A . n A 1 169 ASN 169 169 169 ASN ASN A . n A 1 170 ASN 170 170 170 ASN ASN A . n A 1 171 GLY 171 171 171 GLY GLY A . n A 1 172 MET 172 172 172 MET MET A . n A 1 173 ALA 173 173 173 ALA ALA A . n A 1 174 PHE 174 174 174 PHE PHE A . n A 1 175 LEU 175 175 175 LEU LEU A . n A 1 176 TYR 176 176 176 TYR TYR A . n A 1 177 GLN 177 177 177 GLN GLN A . n A 1 178 SER 178 178 178 SER SER A . n A 1 179 THR 179 179 179 THR THR A . n A 1 180 ASP 180 180 180 ASP ASP A . n A 1 181 PHE 181 181 181 PHE PHE A . n A 1 182 VAL 182 182 182 VAL VAL A . n A 1 183 ASN 183 183 183 ASN ASN A . n A 1 184 TRP 184 184 184 TRP TRP A . n A 1 185 LYS 185 185 185 LYS LYS A . n A 1 186 ARG 186 186 186 ARG ARG A . n A 1 187 TYR 187 187 187 TYR TYR A . n A 1 188 ASP 188 188 188 ASP ASP A . n A 1 189 GLN 189 189 189 GLN GLN A . n A 1 190 PRO 190 190 190 PRO PRO A . n A 1 191 LEU 191 191 191 LEU LEU A . n A 1 192 SER 192 192 192 SER SER A . n A 1 193 SER 193 193 193 SER SER A . n A 1 194 ALA 194 194 194 ALA ALA A . n A 1 195 ASP 195 195 195 ASP ASP A . n A 1 196 ALA 196 196 196 ALA ALA A . n A 1 197 THR 197 197 197 THR THR A . n A 1 198 GLY 198 198 198 GLY GLY A . n A 1 199 THR 199 199 199 THR THR A . n A 1 200 TRP 200 200 200 TRP TRP A . n A 1 201 GLN 201 201 201 GLN GLN A . n A 1 202 CYS 202 202 202 CYS CYS A . n A 1 203 PRO 203 203 203 PRO PRO A . n A 1 204 ASP 204 204 204 ASP ASP A . n A 1 205 PHE 205 205 205 PHE PHE A . n A 1 206 TYR 206 206 206 TYR TYR A . n A 1 207 PRO 207 207 207 PRO PRO A . n A 1 208 VAL 208 208 208 VAL VAL A . n A 1 209 PRO 209 209 209 PRO PRO A . n A 1 210 LEU 210 210 210 LEU LEU A . n A 1 211 ASN 211 211 211 ASN ASN A . n A 1 212 SER 212 212 212 SER SER A . n A 1 213 THR 213 213 213 THR THR A . n A 1 214 ASN 214 214 214 ASN ASN A . n A 1 215 GLY 215 215 215 GLY GLY A . n A 1 216 LEU 216 216 216 LEU LEU A . n A 1 217 ASP 217 217 217 ASP ASP A . n A 1 218 THR 218 218 218 THR THR A . n A 1 219 SER 219 219 219 SER SER A . n A 1 220 VAL 220 220 220 VAL VAL A . n A 1 221 TYR 221 221 221 TYR TYR A . n A 1 222 GLY 222 222 222 GLY GLY A . n A 1 223 GLY 223 223 223 GLY GLY A . n A 1 224 SER 224 224 224 SER SER A . n A 1 225 VAL 225 225 225 VAL VAL A . n A 1 226 ARG 226 226 226 ARG ARG A . n A 1 227 HIS 227 227 227 HIS HIS A . n A 1 228 VAL 228 228 228 VAL VAL A . n A 1 229 MET 229 229 229 MET MET A . n A 1 230 LYS 230 230 230 LYS LYS A . n A 1 231 ALA 231 231 231 ALA ALA A . n A 1 232 GLY 232 232 232 GLY GLY A . n A 1 233 PHE 233 233 233 PHE PHE A . n A 1 234 GLU 234 234 234 GLU GLU A . n A 1 235 GLY 235 235 235 GLY GLY A . n A 1 236 HIS 236 236 236 HIS HIS A . n A 1 237 ASP 237 237 237 ASP ASP A . n A 1 238 TRP 238 238 238 TRP TRP A . n A 1 239 TYR 239 239 239 TYR TYR A . n A 1 240 THR 240 240 240 THR THR A . n A 1 241 ILE 241 241 241 ILE ILE A . n A 1 242 GLY 242 242 242 GLY GLY A . n A 1 243 THR 243 243 243 THR THR A . n A 1 244 TYR 244 244 244 TYR TYR A . n A 1 245 SER 245 245 245 SER SER A . n A 1 246 PRO 246 246 246 PRO PRO A . n A 1 247 ASP 247 247 247 ASP ASP A . n A 1 248 ARG 248 248 248 ARG ARG A . n A 1 249 GLU 249 249 249 GLU GLU A . n A 1 250 ASN 250 250 250 ASN ASN A . n A 1 251 PHE 251 251 251 PHE PHE A . n A 1 252 LEU 252 252 252 LEU LEU A . n A 1 253 PRO 253 253 253 PRO PRO A . n A 1 254 GLN 254 254 254 GLN GLN A . n A 1 255 ASN 255 255 255 ASN ASN A . n A 1 256 GLY 256 256 256 GLY GLY A . n A 1 257 LEU 257 257 257 LEU LEU A . n A 1 258 SER 258 258 258 SER SER A . n A 1 259 LEU 259 259 259 LEU LEU A . n A 1 260 THR 260 260 260 THR THR A . n A 1 261 GLY 261 261 261 GLY GLY A . n A 1 262 SER 262 262 262 SER SER A . n A 1 263 THR 263 263 263 THR THR A . n A 1 264 LEU 264 264 264 LEU LEU A . n A 1 265 ASP 265 265 265 ASP ASP A . n A 1 266 LEU 266 266 266 LEU LEU A . n A 1 267 ARG 267 267 267 ARG ARG A . n A 1 268 TYR 268 268 268 TYR TYR A . n A 1 269 ASP 269 269 269 ASP ASP A . n A 1 270 TYR 270 270 270 TYR TYR A . n A 1 271 GLY 271 271 271 GLY GLY A . n A 1 272 GLN 272 272 272 GLN GLN A . n A 1 273 PHE 273 273 273 PHE PHE A . n A 1 274 TYR 274 274 274 TYR TYR A . n A 1 275 ALA 275 275 275 ALA ALA A . n A 1 276 SER 276 276 276 SER SER A . n A 1 277 LYS 277 277 277 LYS LYS A . n A 1 278 SER 278 278 278 SER SER A . n A 1 279 PHE 279 279 279 PHE PHE A . n A 1 280 PHE 280 280 280 PHE PHE A . n A 1 281 ASP 281 281 281 ASP ASP A . n A 1 282 ASP 282 282 282 ASP ASP A . n A 1 283 ALA 283 283 283 ALA ALA A . n A 1 284 LYS 284 284 284 LYS LYS A . n A 1 285 ASN 285 285 285 ASN ASN A . n A 1 286 ARG 286 286 286 ARG ARG A . n A 1 287 ARG 287 287 287 ARG ARG A . n A 1 288 VAL 288 288 288 VAL VAL A . n A 1 289 LEU 289 289 289 LEU LEU A . n A 1 290 TRP 290 290 290 TRP TRP A . n A 1 291 ALA 291 291 291 ALA ALA A . n A 1 292 TRP 292 292 292 TRP TRP A . n A 1 293 VAL 293 293 293 VAL VAL A . n A 1 294 PRO 294 294 294 PRO PRO A . n A 1 295 GLU 295 295 295 GLU GLU A . n A 1 296 THR 296 296 296 THR THR A . n A 1 297 ASP 297 297 297 ASP ASP A . n A 1 298 SER 298 298 298 SER SER A . n A 1 299 GLN 299 299 299 GLN GLN A . n A 1 300 ALA 300 300 300 ALA ALA A . n A 1 301 ASP 301 301 301 ASP ASP A . n A 1 302 ASP 302 302 302 ASP ASP A . n A 1 303 ILE 303 303 303 ILE ILE A . n A 1 304 GLU 304 304 304 GLU GLU A . n A 1 305 LYS 305 305 305 LYS LYS A . n A 1 306 GLY 306 306 306 GLY GLY A . n A 1 307 TRP 307 307 307 TRP TRP A . n A 1 308 ALA 308 308 308 ALA ALA A . n A 1 309 GLY 309 309 309 GLY GLY A . n A 1 310 LEU 310 310 310 LEU LEU A . n A 1 311 GLN 311 311 311 GLN GLN A . n A 1 312 SER 312 312 312 SER SER A . n A 1 313 PHE 313 313 313 PHE PHE A . n A 1 314 PRO 314 314 314 PRO PRO A . n A 1 315 ARG 315 315 315 ARG ARG A . n A 1 316 ALA 316 316 316 ALA ALA A . n A 1 317 LEU 317 317 317 LEU LEU A . n A 1 318 TRP 318 318 318 TRP TRP A . n A 1 319 ILE 319 319 319 ILE ILE A . n A 1 320 ASP 320 320 320 ASP ASP A . n A 1 321 ARG 321 321 321 ARG ARG A . n A 1 322 ASN 322 322 322 ASN ASN A . n A 1 323 GLY 323 323 323 GLY GLY A . n A 1 324 LYS 324 324 324 LYS LYS A . n A 1 325 GLN 325 325 325 GLN GLN A . n A 1 326 LEU 326 326 326 LEU LEU A . n A 1 327 ILE 327 327 327 ILE ILE A . n A 1 328 GLN 328 328 328 GLN GLN A . n A 1 329 TRP 329 329 329 TRP TRP A . n A 1 330 PRO 330 330 330 PRO PRO A . n A 1 331 VAL 331 331 331 VAL VAL A . n A 1 332 GLU 332 332 332 GLU GLU A . n A 1 333 GLU 333 333 333 GLU GLU A . n A 1 334 ILE 334 334 334 ILE ILE A . n A 1 335 GLU 335 335 335 GLU GLU A . n A 1 336 GLU 336 336 336 GLU GLU A . n A 1 337 LEU 337 337 337 LEU LEU A . n A 1 338 ARG 338 338 338 ARG ARG A . n A 1 339 GLN 339 339 339 GLN GLN A . n A 1 340 ASN 340 340 340 ASN ASN A . n A 1 341 GLN 341 341 341 GLN GLN A . n A 1 342 VAL 342 342 342 VAL VAL A . n A 1 343 ASN 343 343 343 ASN ASN A . n A 1 344 LEU 344 344 344 LEU LEU A . n A 1 345 GLN 345 345 345 GLN GLN A . n A 1 346 ASN 346 346 346 ASN ASN A . n A 1 347 LYS 347 347 347 LYS LYS A . n A 1 348 ASN 348 348 348 ASN ASN A . n A 1 349 LEU 349 349 349 LEU LEU A . n A 1 350 LYS 350 350 350 LYS LYS A . n A 1 351 PRO 351 351 351 PRO PRO A . n A 1 352 GLY 352 352 352 GLY GLY A . n A 1 353 SER 353 353 353 SER SER A . n A 1 354 VAL 354 354 354 VAL VAL A . n A 1 355 LEU 355 355 355 LEU LEU A . n A 1 356 GLU 356 356 356 GLU GLU A . n A 1 357 ILE 357 357 357 ILE ILE A . n A 1 358 HIS 358 358 358 HIS HIS A . n A 1 359 GLY 359 359 359 GLY GLY A . n A 1 360 ILE 360 360 360 ILE ILE A . n A 1 361 ALA 361 361 361 ALA ALA A . n A 1 362 ALA 362 362 362 ALA ALA A . n A 1 363 SER 363 363 363 SER SER A . n A 1 364 GLN 364 364 364 GLN GLN A . n A 1 365 ALA 365 365 365 ALA ALA A . n A 1 366 ASP 366 366 366 ASP ASP A . n A 1 367 VAL 367 367 367 VAL VAL A . n A 1 368 THR 368 368 368 THR THR A . n A 1 369 ILE 369 369 369 ILE ILE A . n A 1 370 SER 370 370 370 SER SER A . n A 1 371 PHE 371 371 371 PHE PHE A . n A 1 372 LYS 372 372 372 LYS LYS A . n A 1 373 LEU 373 373 373 LEU LEU A . n A 1 374 GLU 374 374 374 GLU GLU A . n A 1 375 GLY 375 375 375 GLY GLY A . n A 1 376 LEU 376 376 376 LEU LEU A . n A 1 377 LYS 377 377 377 LYS LYS A . n A 1 378 GLU 378 378 378 GLU GLU A . n A 1 379 ALA 379 379 379 ALA ALA A . n A 1 380 GLU 380 380 380 GLU GLU A . n A 1 381 VAL 381 381 381 VAL VAL A . n A 1 382 LEU 382 382 382 LEU LEU A . n A 1 383 ASP 383 383 383 ASP ASP A . n A 1 384 THR 384 384 384 THR THR A . n A 1 385 THR 385 385 385 THR THR A . n A 1 386 LEU 386 386 386 LEU LEU A . n A 1 387 VAL 387 387 387 VAL VAL A . n A 1 388 ASP 388 388 388 ASP ASP A . n A 1 389 PRO 389 389 389 PRO PRO A . n A 1 390 GLN 390 390 390 GLN GLN A . n A 1 391 ALA 391 391 391 ALA ALA A . n A 1 392 LEU 392 392 392 LEU LEU A . n A 1 393 CYS 393 393 393 CYS CYS A . n A 1 394 ASN 394 394 394 ASN ASN A . n A 1 395 GLU 395 395 395 GLU GLU A . n A 1 396 ARG 396 396 396 ARG ARG A . n A 1 397 GLY 397 397 397 GLY GLY A . n A 1 398 ALA 398 398 398 ALA ALA A . n A 1 399 SER 399 399 399 SER SER A . n A 1 400 SER 400 400 400 SER SER A . n A 1 401 ARG 401 401 401 ARG ARG A . n A 1 402 GLY 402 402 402 GLY GLY A . n A 1 403 ALA 403 403 403 ALA ALA A . n A 1 404 LEU 404 404 404 LEU LEU A . n A 1 405 GLY 405 405 405 GLY GLY A . n A 1 406 PRO 406 406 406 PRO PRO A . n A 1 407 PHE 407 407 407 PHE PHE A . n A 1 408 GLY 408 408 408 GLY GLY A . n A 1 409 LEU 409 409 409 LEU LEU A . n A 1 410 LEU 410 410 410 LEU LEU A . n A 1 411 ALA 411 411 411 ALA ALA A . n A 1 412 MET 412 412 412 MET MET A . n A 1 413 ALA 413 413 413 ALA ALA A . n A 1 414 SER 414 414 414 SER SER A . n A 1 415 LYS 415 415 415 LYS LYS A . n A 1 416 ASP 416 416 416 ASP ASP A . n A 1 417 LEU 417 417 417 LEU LEU A . n A 1 418 LYS 418 418 418 LYS LYS A . n A 1 419 GLU 419 419 419 GLU GLU A . n A 1 420 GLN 420 420 420 GLN GLN A . n A 1 421 SER 421 421 421 SER SER A . n A 1 422 ALA 422 422 422 ALA ALA A . n A 1 423 ILE 423 423 423 ILE ILE A . n A 1 424 PHE 424 424 424 PHE PHE A . n A 1 425 PHE 425 425 425 PHE PHE A . n A 1 426 ARG 426 426 426 ARG ARG A . n A 1 427 VAL 427 427 427 VAL VAL A . n A 1 428 PHE 428 428 428 PHE PHE A . n A 1 429 GLN 429 429 429 GLN GLN A . n A 1 430 ASN 430 430 430 ASN ASN A . n A 1 431 GLN 431 431 431 GLN GLN A . n A 1 432 LEU 432 432 432 LEU LEU A . n A 1 433 GLY 433 433 433 GLY GLY A . n A 1 434 ARG 434 434 434 ARG ARG A . n A 1 435 TYR 435 435 435 TYR TYR A . n A 1 436 SER 436 436 436 SER SER A . n A 1 437 VAL 437 437 437 VAL VAL A . n A 1 438 LEU 438 438 438 LEU LEU A . n A 1 439 MET 439 439 439 MET MET A . n A 1 440 CYS 440 440 440 CYS CYS A . n A 1 441 SER 441 441 441 SER SER A . n A 1 442 ASP 442 442 442 ASP ASP A . n A 1 443 LEU 443 443 443 LEU LEU A . n A 1 444 SER 444 444 444 SER SER A . n A 1 445 ARG 445 445 445 ARG ARG A . n A 1 446 SER 446 446 446 SER SER A . n A 1 447 THR 447 447 447 THR THR A . n A 1 448 VAL 448 448 448 VAL VAL A . n A 1 449 ARG 449 449 449 ARG ARG A . n A 1 450 SER 450 450 450 SER SER A . n A 1 451 ASN 451 451 451 ASN ASN A . n A 1 452 ILE 452 452 452 ILE ILE A . n A 1 453 ASP 453 453 453 ASP ASP A . n A 1 454 THR 454 454 454 THR THR A . n A 1 455 THR 455 455 455 THR THR A . n A 1 456 SER 456 456 456 SER SER A . n A 1 457 TYR 457 457 457 TYR TYR A . n A 1 458 GLY 458 458 458 GLY GLY A . n A 1 459 ALA 459 459 459 ALA ALA A . n A 1 460 PHE 460 460 460 PHE PHE A . n A 1 461 VAL 461 461 461 VAL VAL A . n A 1 462 ASP 462 462 462 ASP ASP A . n A 1 463 ILE 463 463 463 ILE ILE A . n A 1 464 ASP 464 464 464 ASP ASP A . n A 1 465 PRO 465 465 465 PRO PRO A . n A 1 466 ARG 466 466 466 ARG ARG A . n A 1 467 SER 467 467 467 SER SER A . n A 1 468 GLU 468 468 468 GLU GLU A . n A 1 469 GLU 469 469 469 GLU GLU A . n A 1 470 ILE 470 470 470 ILE ILE A . n A 1 471 SER 471 471 471 SER SER A . n A 1 472 LEU 472 472 472 LEU LEU A . n A 1 473 ARG 473 473 473 ARG ARG A . n A 1 474 ASN 474 474 474 ASN ASN A . n A 1 475 LEU 475 475 475 LEU LEU A . n A 1 476 ILE 476 476 476 ILE ILE A . n A 1 477 ASP 477 477 477 ASP ASP A . n A 1 478 HIS 478 478 478 HIS HIS A . n A 1 479 SER 479 479 479 SER SER A . n A 1 480 ILE 480 480 480 ILE ILE A . n A 1 481 ILE 481 481 481 ILE ILE A . n A 1 482 GLU 482 482 482 GLU GLU A . n A 1 483 SER 483 483 483 SER SER A . n A 1 484 PHE 484 484 484 PHE PHE A . n A 1 485 GLY 485 485 485 GLY GLY A . n A 1 486 ALA 486 486 486 ALA ALA A . n A 1 487 GLY 487 487 487 GLY GLY A . n A 1 488 GLY 488 488 488 GLY GLY A . n A 1 489 LYS 489 489 489 LYS LYS A . n A 1 490 THR 490 490 490 THR THR A . n A 1 491 CYS 491 491 491 CYS CYS A . n A 1 492 ILE 492 492 492 ILE ILE A . n A 1 493 THR 493 493 493 THR THR A . n A 1 494 SER 494 494 494 SER SER A . n A 1 495 ARG 495 495 495 ARG ARG A . n A 1 496 ILE 496 496 496 ILE ILE A . n A 1 497 TYR 497 497 497 TYR TYR A . n A 1 498 PRO 498 498 498 PRO PRO A . n A 1 499 LYS 499 499 499 LYS LYS A . n A 1 500 PHE 500 500 500 PHE PHE A . n A 1 501 VAL 501 501 501 VAL VAL A . n A 1 502 ASN 502 502 502 ASN ASN A . n A 1 503 ASN 503 503 503 ASN ASN A . n A 1 504 GLU 504 504 504 GLU GLU A . n A 1 505 GLU 505 505 505 GLU GLU A . n A 1 506 ALA 506 506 506 ALA ALA A . n A 1 507 HIS 507 507 507 HIS HIS A . n A 1 508 LEU 508 508 508 LEU LEU A . n A 1 509 PHE 509 509 509 PHE PHE A . n A 1 510 VAL 510 510 510 VAL VAL A . n A 1 511 PHE 511 511 511 PHE PHE A . n A 1 512 ASN 512 512 512 ASN ASN A . n A 1 513 ASN 513 513 513 ASN ASN A . n A 1 514 GLY 514 514 514 GLY GLY A . n A 1 515 THR 515 515 515 THR THR A . n A 1 516 GLN 516 516 516 GLN GLN A . n A 1 517 ASN 517 517 517 ASN ASN A . n A 1 518 VAL 518 518 518 VAL VAL A . n A 1 519 LYS 519 519 519 LYS LYS A . n A 1 520 ILE 520 520 520 ILE ILE A . n A 1 521 SER 521 521 521 SER SER A . n A 1 522 GLU 522 522 522 GLU GLU A . n A 1 523 MET 523 523 523 MET MET A . n A 1 524 SER 524 524 524 SER SER A . n A 1 525 ALA 525 525 525 ALA ALA A . n A 1 526 TRP 526 526 526 TRP TRP A . n A 1 527 SER 527 527 527 SER SER A . n A 1 528 MET 528 528 528 MET MET A . n A 1 529 LYS 529 529 529 LYS LYS A . n A 1 530 ASN 530 530 530 ASN ASN A . n A 1 531 ALA 531 531 531 ALA ALA A . n A 1 532 LYS 532 532 532 LYS LYS A . n A 1 533 PHE 533 533 533 PHE PHE A . n A 1 534 VAL 534 534 534 VAL VAL A . n A 1 535 VAL 535 535 535 VAL VAL A . n A 1 536 ASP 536 536 536 ASP ASP A . n A 1 537 GLN 537 537 537 GLN GLN A . n A 1 538 SER 538 538 538 SER SER A . n A 1 539 VAL 539 539 ? ? ? A . n A 1 540 LYS 540 540 ? ? ? A . n A 1 541 SER 541 541 ? ? ? A . n A 1 542 ALA 542 542 ? ? ? A . n A 1 543 ALA 543 543 ? ? ? A . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code B 2 NAG 1 650 650 NAG NAG A . C 3 NDG 2 660 660 NDG NAG A . D 2 NAG 1 680 680 NAG NAG A . E 2 NAG 2 690 690 NAG NAG A . F 4 BMA 3 700 700 BMA MAN A . G 4 BMA 4 710 710 BMA MAN A . H 5 DQR 1 801 801 DQR DQR A . I 6 HOH 1 1001 1001 HOH HOH A . I 6 HOH 2 1002 1002 HOH HOH A . I 6 HOH 3 1003 1003 HOH HOH A . I 6 HOH 4 1004 1004 HOH HOH A . I 6 HOH 5 1005 1005 HOH HOH A . I 6 HOH 6 1006 1006 HOH HOH A . I 6 HOH 7 1007 1007 HOH HOH A . I 6 HOH 8 1008 1008 HOH HOH A . I 6 HOH 9 1009 1009 HOH HOH A . I 6 HOH 10 1010 1010 HOH HOH A . I 6 HOH 11 1011 1011 HOH HOH A . I 6 HOH 12 1012 1012 HOH HOH A . I 6 HOH 13 1013 1013 HOH HOH A . I 6 HOH 14 1014 1014 HOH HOH A . I 6 HOH 15 1015 1015 HOH HOH A . I 6 HOH 16 1016 1016 HOH HOH A . I 6 HOH 17 1017 1017 HOH HOH A . I 6 HOH 18 1018 1018 HOH HOH A . I 6 HOH 19 1019 1019 HOH HOH A . I 6 HOH 20 1020 1020 HOH HOH A . I 6 HOH 21 1021 1021 HOH HOH A . I 6 HOH 22 1022 1022 HOH HOH A . I 6 HOH 23 1023 1023 HOH HOH A . I 6 HOH 24 1024 1024 HOH HOH A . I 6 HOH 25 1025 1025 HOH HOH A . I 6 HOH 26 1026 1026 HOH HOH A . I 6 HOH 27 1027 1027 HOH HOH A . I 6 HOH 28 1028 1028 HOH HOH A . I 6 HOH 29 1029 1029 HOH HOH A . I 6 HOH 30 1030 1030 HOH HOH A . I 6 HOH 31 1031 1031 HOH HOH A . I 6 HOH 32 1032 1032 HOH HOH A . I 6 HOH 33 1033 1033 HOH HOH A . I 6 HOH 34 1034 1034 HOH HOH A . I 6 HOH 35 1035 1035 HOH HOH A . I 6 HOH 36 1036 1036 HOH HOH A . I 6 HOH 37 1037 1037 HOH HOH A . I 6 HOH 38 1038 1038 HOH HOH A . I 6 HOH 39 1039 1039 HOH HOH A . I 6 HOH 40 1040 1040 HOH HOH A . I 6 HOH 41 1041 1041 HOH HOH A . I 6 HOH 42 1042 1042 HOH HOH A . I 6 HOH 43 1043 1043 HOH HOH A . I 6 HOH 44 1044 1044 HOH HOH A . I 6 HOH 45 1045 1045 HOH HOH A . I 6 HOH 46 1046 1046 HOH HOH A . I 6 HOH 47 1047 1047 HOH HOH A . I 6 HOH 48 1048 1048 HOH HOH A . I 6 HOH 49 1049 1049 HOH HOH A . I 6 HOH 50 1050 1050 HOH HOH A . I 6 HOH 51 1051 1051 HOH HOH A . I 6 HOH 52 1052 1052 HOH HOH A . I 6 HOH 53 1053 1053 HOH HOH A . I 6 HOH 54 1054 1054 HOH HOH A . I 6 HOH 55 1055 1055 HOH HOH A . I 6 HOH 56 1056 1056 HOH HOH A . I 6 HOH 57 1057 1057 HOH HOH A . I 6 HOH 58 1058 1058 HOH HOH A . I 6 HOH 59 1059 1059 HOH HOH A . I 6 HOH 60 1060 1060 HOH HOH A . I 6 HOH 61 1061 1061 HOH HOH A . I 6 HOH 62 1062 1062 HOH HOH A . I 6 HOH 63 1063 1063 HOH HOH A . I 6 HOH 64 1064 1064 HOH HOH A . I 6 HOH 65 1065 1065 HOH HOH A . I 6 HOH 66 1066 1066 HOH HOH A . I 6 HOH 67 1067 1067 HOH HOH A . I 6 HOH 68 1068 1068 HOH HOH A . I 6 HOH 69 1069 1069 HOH HOH A . I 6 HOH 70 1070 1070 HOH HOH A . I 6 HOH 71 1071 1071 HOH HOH A . I 6 HOH 72 1072 1072 HOH HOH A . I 6 HOH 73 1073 1073 HOH HOH A . I 6 HOH 74 1074 1074 HOH HOH A . I 6 HOH 75 1075 1075 HOH HOH A . I 6 HOH 76 1076 1076 HOH HOH A . I 6 HOH 77 1077 1077 HOH HOH A . I 6 HOH 78 1078 1078 HOH HOH A . I 6 HOH 79 1079 1079 HOH HOH A . I 6 HOH 80 1080 1080 HOH HOH A . I 6 HOH 81 1081 1081 HOH HOH A . I 6 HOH 82 1082 1082 HOH HOH A . I 6 HOH 83 1083 1083 HOH HOH A . I 6 HOH 84 1084 1084 HOH HOH A . I 6 HOH 85 1085 1085 HOH HOH A . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 116 A ASN 116 ? ASN 'GLYCOSYLATION SITE' 2 A ASN 513 A ASN 513 ? ASN 'GLYCOSYLATION SITE' # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_defined_assembly _pdbx_struct_assembly.method_details ? _pdbx_struct_assembly.oligomeric_details monomeric _pdbx_struct_assembly.oligomeric_count 1 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G,H,I # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2006-08-29 2 'Structure model' 1 1 2008-04-30 3 'Structure model' 1 2 2011-07-13 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Version format compliance' 2 3 'Structure model' 'Non-polymer description' 3 3 'Structure model' 'Version format compliance' # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal CNS refinement 1.1 ? 1 DENZO 'data reduction' . ? 2 SCALEPACK 'data scaling' . ? 3 CNS phasing . ? 4 # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 TYR A 11 ? ? -140.45 20.30 2 1 GLN A 14 ? ? -170.31 142.60 3 1 ASN A 18 ? ? 76.40 -164.03 4 1 ASN A 21 ? ? -137.84 -127.91 5 1 ASP A 22 ? ? -31.08 120.73 6 1 THR A 73 ? ? -148.84 10.24 7 1 ASP A 77 ? ? -154.74 24.70 8 1 SER A 80 ? ? 172.38 155.89 9 1 SER A 83 ? ? -44.18 151.14 10 1 LYS A 104 ? ? -90.45 34.06 11 1 LEU A 117 ? ? -66.56 0.43 12 1 LEU A 122 ? ? 32.60 60.61 13 1 PRO A 136 ? ? -39.50 119.20 14 1 GLU A 138 ? ? -29.22 -74.10 15 1 CYS A 144 ? ? -147.85 43.92 16 1 ASP A 147 ? ? 62.49 63.95 17 1 ASP A 166 ? ? 177.61 161.05 18 1 ALA A 196 ? ? 35.52 56.64 19 1 SER A 219 ? ? -95.48 43.38 20 1 THR A 263 ? ? -66.20 4.46 21 1 GLN A 339 ? ? -109.45 -112.17 22 1 ALA A 362 ? ? -39.35 -23.02 23 1 ALA A 403 ? ? -68.58 -76.20 24 1 MET A 412 ? ? 39.90 54.20 25 1 PRO A 465 ? ? -58.30 -8.29 26 1 SER A 467 ? ? -172.09 15.14 27 1 HIS A 478 ? ? 57.24 -89.99 28 1 ASN A 503 ? ? -141.92 -64.73 29 1 GLN A 537 ? ? -129.02 -106.44 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A GLN 1 ? A GLN 1 2 1 Y 1 A GLN 2 ? A GLN 2 3 1 Y 1 A VAL 539 ? A VAL 539 4 1 Y 1 A LYS 540 ? A LYS 540 5 1 Y 1 A SER 541 ? A SER 541 6 1 Y 1 A ALA 542 ? A ALA 542 7 1 Y 1 A ALA 543 ? A ALA 543 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 '2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE' NDG 4 BETA-D-MANNOSE BMA 5 'beta-D-fructofuranosyl-(2->1)-beta-D-fructofuranosyl alpha-D-glucopyranoside' DQR 6 water HOH #