data_1T80 # _entry.id 1T80 # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.286 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 1T80 RCSB RCSB022426 WWPDB D_1000022426 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.details _pdbx_database_related.content_type PDB 1ZAG . unspecified PDB 1t7v . unspecified PDB 1t7w . unspecified PDB 1t7x . unspecified PDB 1t7y . unspecified PDB 1t7z . unspecified # _pdbx_database_status.entry_id 1T80 _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.recvd_initial_deposition_date 2004-05-11 _pdbx_database_status.status_code REL _pdbx_database_status.status_code_sf REL _pdbx_database_status.SG_entry . _pdbx_database_status.pdb_format_compatible Y _pdbx_database_status.status_code_mr ? _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Delker, S.L.' 1 'West Jr., A.P.' 2 'McDermott, L.' 3 'Kennedy, M.W.' 4 'Bjorkman, P.J.' 5 # loop_ _citation.id _citation.title _citation.journal_abbrev _citation.journal_volume _citation.page_first _citation.page_last _citation.year _citation.journal_id_ASTM _citation.country _citation.journal_id_ISSN _citation.journal_id_CSD _citation.book_publisher _citation.pdbx_database_id_PubMed _citation.pdbx_database_id_DOI primary 'Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein.' J.Struct.Biol. 148 205 213 2004 JSBIEM US 1047-8477 0803 ? 15477100 10.1016/j.jsb.2004.04.009 1 'Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules' Science 283 1914 1919 1999 SCIEAS US 0036-8075 0038 ? ? 10.1126/science.283.5409.1914 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Delker, S.L.' 1 primary 'West Jr., A.P.' 2 primary 'McDermott, L.' 3 primary 'Kennedy, M.W.' 4 primary 'Bjorkman, P.J.' 5 1 'Sanchez, L.M.' 6 1 'Chirino, A.J.' 7 1 'Bjorkman, P.J.' 8 # _cell.entry_id 1T80 _cell.length_a 122.545 _cell.length_b 122.545 _cell.length_c 65.445 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 90.00 _cell.pdbx_unique_axis ? _cell.Z_PDB 8 # _symmetry.entry_id 1T80 _symmetry.space_group_name_H-M 'P 43 21 2' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.Int_Tables_number 96 _symmetry.cell_setting ? _symmetry.space_group_name_Hall ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man Zinc-alpha-2-glycoprotein 32185.953 1 ? 'N89K, N92T' ? ? 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 3 ? ? ? ? 3 water nat water 18.015 185 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name 'Zn-alpha-2-glycoprotein, Zn-alpha-2-GP' # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;QENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFRYNSKDRKSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMET LKDIVEYYKDSTGSHVLQGRFGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQRAKA YLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVHWTRAGEVQEPELRGDVLHNGNG TYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVPWEAS ; _entity_poly.pdbx_seq_one_letter_code_can ;QENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFRYNSKDRKSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMET LKDIVEYYKDSTGSHVLQGRFGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQRAKA YLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVHWTRAGEVQEPELRGDVLHNGNG TYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVPWEAS ; _entity_poly.pdbx_strand_id A _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 GLN n 1 2 GLU n 1 3 ASN n 1 4 GLN n 1 5 ASP n 1 6 GLY n 1 7 ARG n 1 8 TYR n 1 9 SER n 1 10 LEU n 1 11 THR n 1 12 TYR n 1 13 ILE n 1 14 TYR n 1 15 THR n 1 16 GLY n 1 17 LEU n 1 18 SER n 1 19 LYS n 1 20 HIS n 1 21 VAL n 1 22 GLU n 1 23 ASP n 1 24 VAL n 1 25 PRO n 1 26 ALA n 1 27 PHE n 1 28 GLN n 1 29 ALA n 1 30 LEU n 1 31 GLY n 1 32 SER n 1 33 LEU n 1 34 ASN n 1 35 ASP n 1 36 LEU n 1 37 GLN n 1 38 PHE n 1 39 PHE n 1 40 ARG n 1 41 TYR n 1 42 ASN n 1 43 SER n 1 44 LYS n 1 45 ASP n 1 46 ARG n 1 47 LYS n 1 48 SER n 1 49 GLN n 1 50 PRO n 1 51 MET n 1 52 GLY n 1 53 LEU n 1 54 TRP n 1 55 ARG n 1 56 GLN n 1 57 VAL n 1 58 GLU n 1 59 GLY n 1 60 MET n 1 61 GLU n 1 62 ASP n 1 63 TRP n 1 64 LYS n 1 65 GLN n 1 66 ASP n 1 67 SER n 1 68 GLN n 1 69 LEU n 1 70 GLN n 1 71 LYS n 1 72 ALA n 1 73 ARG n 1 74 GLU n 1 75 ASP n 1 76 ILE n 1 77 PHE n 1 78 MET n 1 79 GLU n 1 80 THR n 1 81 LEU n 1 82 LYS n 1 83 ASP n 1 84 ILE n 1 85 VAL n 1 86 GLU n 1 87 TYR n 1 88 TYR n 1 89 LYS n 1 90 ASP n 1 91 SER n 1 92 THR n 1 93 GLY n 1 94 SER n 1 95 HIS n 1 96 VAL n 1 97 LEU n 1 98 GLN n 1 99 GLY n 1 100 ARG n 1 101 PHE n 1 102 GLY n 1 103 CYS n 1 104 GLU n 1 105 ILE n 1 106 GLU n 1 107 ASN n 1 108 ASN n 1 109 ARG n 1 110 SER n 1 111 SER n 1 112 GLY n 1 113 ALA n 1 114 PHE n 1 115 TRP n 1 116 LYS n 1 117 TYR n 1 118 TYR n 1 119 TYR n 1 120 ASP n 1 121 GLY n 1 122 LYS n 1 123 ASP n 1 124 TYR n 1 125 ILE n 1 126 GLU n 1 127 PHE n 1 128 ASN n 1 129 LYS n 1 130 GLU n 1 131 ILE n 1 132 PRO n 1 133 ALA n 1 134 TRP n 1 135 VAL n 1 136 PRO n 1 137 PHE n 1 138 ASP n 1 139 PRO n 1 140 ALA n 1 141 ALA n 1 142 GLN n 1 143 ILE n 1 144 THR n 1 145 LYS n 1 146 GLN n 1 147 LYS n 1 148 TRP n 1 149 GLU n 1 150 ALA n 1 151 GLU n 1 152 PRO n 1 153 VAL n 1 154 TYR n 1 155 VAL n 1 156 GLN n 1 157 ARG n 1 158 ALA n 1 159 LYS n 1 160 ALA n 1 161 TYR n 1 162 LEU n 1 163 GLU n 1 164 GLU n 1 165 GLU n 1 166 CYS n 1 167 PRO n 1 168 ALA n 1 169 THR n 1 170 LEU n 1 171 ARG n 1 172 LYS n 1 173 TYR n 1 174 LEU n 1 175 LYS n 1 176 TYR n 1 177 SER n 1 178 LYS n 1 179 ASN n 1 180 ILE n 1 181 LEU n 1 182 ASP n 1 183 ARG n 1 184 GLN n 1 185 ASP n 1 186 PRO n 1 187 PRO n 1 188 SER n 1 189 VAL n 1 190 VAL n 1 191 VAL n 1 192 THR n 1 193 SER n 1 194 HIS n 1 195 GLN n 1 196 ALA n 1 197 PRO n 1 198 GLY n 1 199 GLU n 1 200 LYS n 1 201 LYS n 1 202 LYS n 1 203 LEU n 1 204 LYS n 1 205 CYS n 1 206 LEU n 1 207 ALA n 1 208 TYR n 1 209 ASP n 1 210 PHE n 1 211 TYR n 1 212 PRO n 1 213 GLY n 1 214 LYS n 1 215 ILE n 1 216 ASP n 1 217 VAL n 1 218 HIS n 1 219 TRP n 1 220 THR n 1 221 ARG n 1 222 ALA n 1 223 GLY n 1 224 GLU n 1 225 VAL n 1 226 GLN n 1 227 GLU n 1 228 PRO n 1 229 GLU n 1 230 LEU n 1 231 ARG n 1 232 GLY n 1 233 ASP n 1 234 VAL n 1 235 LEU n 1 236 HIS n 1 237 ASN n 1 238 GLY n 1 239 ASN n 1 240 GLY n 1 241 THR n 1 242 TYR n 1 243 GLN n 1 244 SER n 1 245 TRP n 1 246 VAL n 1 247 VAL n 1 248 VAL n 1 249 ALA n 1 250 VAL n 1 251 PRO n 1 252 PRO n 1 253 GLN n 1 254 ASP n 1 255 THR n 1 256 ALA n 1 257 PRO n 1 258 TYR n 1 259 SER n 1 260 CYS n 1 261 HIS n 1 262 VAL n 1 263 GLN n 1 264 HIS n 1 265 SER n 1 266 SER n 1 267 LEU n 1 268 ALA n 1 269 GLN n 1 270 PRO n 1 271 LEU n 1 272 VAL n 1 273 VAL n 1 274 PRO n 1 275 TRP n 1 276 GLU n 1 277 ALA n 1 278 SER n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name human _entity_src_gen.gene_src_genus Homo _entity_src_gen.pdbx_gene_src_gene 'AZGP1, ZAG, ZNGP1' _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Homo sapiens' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 9606 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name 'Chinese hamster' _entity_src_gen.pdbx_host_org_scientific_name 'Cricetulus griseus' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 10029 _entity_src_gen.host_org_genus Cricetulus _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain ? _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type Plasmid _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name pBJ5-GS _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code ZA2G_HUMAN _struct_ref.pdbx_db_accession P25311 _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;QENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFRYNSKDRKSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMET LKDIVEYYNDSNGSHVLQGRFGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQRAKA YLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVHWTRAGEVQEPELRGDVLHNGNG TYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVPWEAS ; _struct_ref.pdbx_align_begin 18 _struct_ref.pdbx_db_isoform ? # _struct_ref_seq.align_id 1 _struct_ref_seq.ref_id 1 _struct_ref_seq.pdbx_PDB_id_code 1T80 _struct_ref_seq.pdbx_strand_id A _struct_ref_seq.seq_align_beg 1 _struct_ref_seq.pdbx_seq_align_beg_ins_code ? _struct_ref_seq.seq_align_end 278 _struct_ref_seq.pdbx_seq_align_end_ins_code ? _struct_ref_seq.pdbx_db_accession P25311 _struct_ref_seq.db_align_beg 18 _struct_ref_seq.pdbx_db_align_beg_ins_code ? _struct_ref_seq.db_align_end 295 _struct_ref_seq.pdbx_db_align_end_ins_code ? _struct_ref_seq.pdbx_auth_seq_align_beg 1 _struct_ref_seq.pdbx_auth_seq_align_end 278 # loop_ _struct_ref_seq_dif.align_id _struct_ref_seq_dif.pdbx_pdb_id_code _struct_ref_seq_dif.mon_id _struct_ref_seq_dif.pdbx_pdb_strand_id _struct_ref_seq_dif.seq_num _struct_ref_seq_dif.pdbx_pdb_ins_code _struct_ref_seq_dif.pdbx_seq_db_name _struct_ref_seq_dif.pdbx_seq_db_accession_code _struct_ref_seq_dif.db_mon_id _struct_ref_seq_dif.pdbx_seq_db_seq_num _struct_ref_seq_dif.details _struct_ref_seq_dif.pdbx_auth_seq_num _struct_ref_seq_dif.pdbx_ordinal 1 1T80 LYS A 89 ? UNP P25311 ASN 106 ENGINEERED 89 1 1 1T80 THR A 92 ? UNP P25311 ASN 109 ENGINEERED 92 2 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 1T80 _exptl.crystals_number 1 _exptl.method 'X-RAY DIFFRACTION' # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_percent_sol 67.77 _exptl_crystal.density_Matthews 3.82 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method MICROBATCH _exptl_crystal_grow.pH 7.5 _exptl_crystal_grow.temp 298.0 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pdbx_details 'Ammonium sulfate, PEG 200, HEPES, pH 7.5, Microbatch, temperature 298.0K' _exptl_crystal_grow.pdbx_pH_range . # _diffrn.id 1 _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type 'ADSC QUANTUM 315' _diffrn_detector.pdbx_collection_date 2003-06-14 _diffrn_detector.details ? # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.monochromator 'Double crystal Si(111)' _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 1.1271 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'ALS BEAMLINE 8.2.2' _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list 1.1271 _diffrn_source.pdbx_synchrotron_site ALS _diffrn_source.pdbx_synchrotron_beamline 8.2.2 # _reflns.percent_possible_obs 99.700 _reflns.entry_id 1T80 _reflns.observed_criterion_sigma_F ? _reflns.observed_criterion_sigma_I ? _reflns.d_resolution_high 2.1 _reflns.d_resolution_low 20.0 _reflns.number_all ? _reflns.number_obs 29553 _reflns.pdbx_Rmerge_I_obs 0.069 _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI 16.5 _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy 3.7 _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # _reflns_shell.d_res_high 2.1 _reflns_shell.d_res_low 2.17 _reflns_shell.percent_possible_obs 98.400 _reflns_shell.Rmerge_I_obs 0.524 _reflns_shell.percent_possible_all 99.9 _reflns_shell.meanI_over_sigI_obs 2.7 _reflns_shell.pdbx_Rsym_value ? _reflns_shell.pdbx_redundancy ? _reflns_shell.number_unique_all ? _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_unique_obs ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 # _refine.entry_id 1T80 _refine.ls_number_reflns_all 29618 _refine.ls_number_reflns_obs 29531 _refine.ls_percent_reflns_obs 99.7 _refine.ls_d_res_high 2.10 _refine.ls_d_res_low 20.0 _refine.B_iso_min 18.23 _refine.B_iso_max 90.20 _refine.B_iso_mean 42.51 _refine.occupancy_min 1.00 _refine.occupancy_max 1.00 _refine.aniso_B[1][1] 1.61 _refine.aniso_B[2][2] 1.61 _refine.aniso_B[3][3] -3.22 _refine.aniso_B[1][2] 0.00 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_param_bsol 54.6827 _refine.solvent_model_param_ksol 0.38083 _refine.solvent_model_details 'CNS bulk solvent model used' _refine.ls_R_factor_R_work 0.236 _refine.ls_R_factor_R_free 0.265 _refine.ls_R_factor_R_free_error 0.007 _refine.ls_number_reflns_R_free 1344 _refine.ls_percent_reflns_R_free 4.6 _refine.details ? _refine.pdbx_ls_sigma_F ? _refine.pdbx_ls_sigma_I ? _refine.ls_R_factor_all ? _refine.ls_R_factor_obs ? _refine.ls_redundancy_reflns_obs ? _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.ls_R_factor_R_free_error_details ? _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_starting_model 'PDB Entry 1T7V' _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.pdbx_R_Free_selection_details Random _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_stereochemistry_target_values 'Engh & Huber' _refine.pdbx_isotropic_thermal_model ? _refine.correlation_coeff_Fo_to_Fc ? _refine.correlation_coeff_Fo_to_Fc_free ? _refine.pdbx_solvent_vdw_probe_radii ? _refine.pdbx_solvent_ion_probe_radii ? _refine.pdbx_solvent_shrinkage_radii ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.overall_SU_B ? _refine.overall_SU_ML ? _refine.pdbx_overall_ESU_R ? _refine.pdbx_overall_ESU_R_Free ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_phase_error ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_analyze.entry_id 1T80 _refine_analyze.Luzzati_d_res_low_obs 5.00 _refine_analyze.Luzzati_coordinate_error_obs 0.27 _refine_analyze.Luzzati_sigma_a_obs 0.24 _refine_analyze.Luzzati_coordinate_error_free 0.30 _refine_analyze.Luzzati_sigma_a_free 0.27 _refine_analyze.Luzzati_d_res_low_free ? _refine_analyze.number_disordered_residues ? _refine_analyze.occupancy_sum_non_hydrogen ? _refine_analyze.occupancy_sum_hydrogen ? _refine_analyze.pdbx_Luzzati_d_res_high_obs ? _refine_analyze.pdbx_refine_id 'X-RAY DIFFRACTION' # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 2232 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 42 _refine_hist.number_atoms_solvent 185 _refine_hist.number_atoms_total 2459 _refine_hist.d_res_high 2.10 _refine_hist.d_res_low 20.0 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.number _refine_ls_restr.weight _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function x_bond_d 0.006 . ? ? 'X-RAY DIFFRACTION' ? x_angle_deg 1.2 . ? ? 'X-RAY DIFFRACTION' ? x_torsion_deg 24.3 . ? ? 'X-RAY DIFFRACTION' ? x_torsion_impr_deg 0.75 . ? ? 'X-RAY DIFFRACTION' ? x_mcbond_it 1.53 1.50 ? ? 'X-RAY DIFFRACTION' ? x_mcangle_it 2.50 2.00 ? ? 'X-RAY DIFFRACTION' ? x_scbond_it 2.27 2.00 ? ? 'X-RAY DIFFRACTION' ? x_scangle_it 3.44 2.50 ? ? 'X-RAY DIFFRACTION' ? # loop_ _refine_ls_shell.d_res_high _refine_ls_shell.d_res_low _refine_ls_shell.number_reflns_all _refine_ls_shell.number_reflns_obs _refine_ls_shell.number_reflns_R_work _refine_ls_shell.percent_reflns_obs _refine_ls_shell.R_factor_R_work _refine_ls_shell.R_factor_R_free _refine_ls_shell.R_factor_R_free_error _refine_ls_shell.number_reflns_R_free _refine_ls_shell.percent_reflns_R_free _refine_ls_shell.pdbx_total_number_of_bins_used _refine_ls_shell.redundancy_reflns_obs _refine_ls_shell.pdbx_refine_id _refine_ls_shell.R_factor_all 2.10 2.17 2923 2913 2761 99.7 0.282 0.314 0.025 152 5.2 . . 'X-RAY DIFFRACTION' . 2.17 2.26 2911 2895 2766 99.4 0.28 0.296 0.026 129 4.5 . . 'X-RAY DIFFRACTION' . 2.26 2.36 2917 2913 2821 99.8 0.265 0.285 0.030 92 3.2 . . 'X-RAY DIFFRACTION' . 2.36 2.49 2920 2918 2812 99.9 0.256 0.298 0.029 106 3.6 . . 'X-RAY DIFFRACTION' . 2.49 2.64 2925 2921 2773 99.8 0.224 0.258 0.021 148 5.1 . . 'X-RAY DIFFRACTION' . 2.64 2.85 2964 2961 2806 99.9 0.256 0.287 0.023 155 5.2 . . 'X-RAY DIFFRACTION' . 2.85 3.13 2940 2937 2804 99.9 0.241 0.285 0.025 133 4.5 . . 'X-RAY DIFFRACTION' . 3.13 3.59 2969 2964 2823 99.8 0.218 0.22 0.018 141 4.8 . . 'X-RAY DIFFRACTION' . 3.59 4.51 3006 2987 2859 99.4 0.209 0.229 0.020 128 4.3 . . 'X-RAY DIFFRACTION' . 4.51 19.62 3166 3122 2962 98.6 0.242 0.289 0.023 160 5.1 . . 'X-RAY DIFFRACTION' . # _struct.entry_id 1T80 _struct.title 'Zn-alpha-2-glycoprotein; CHO-ZAG PEG 200' _struct.pdbx_descriptor Zinc-alpha-2-glycoprotein _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 1T80 _struct_keywords.pdbx_keywords 'LIPID BINDING PROTEIN' _struct_keywords.text 'MHC class I homolog, LIPID BINDING PROTEIN' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 2 ? D N N 2 ? E N N 3 ? # _struct_biol.id 1 _struct_biol.pdbx_parent_biol_id ? _struct_biol.details ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 GLY A 52 ? VAL A 57 ? GLY A 52 VAL A 57 5 ? 6 HELX_P HELX_P2 2 ASP A 62 ? TYR A 88 ? ASP A 62 TYR A 88 1 ? 27 HELX_P HELX_P3 3 ALA A 140 ? GLU A 149 ? ALA A 140 GLU A 149 1 ? 10 HELX_P HELX_P4 4 PRO A 152 ? GLU A 164 ? PRO A 152 GLU A 164 1 ? 13 HELX_P HELX_P5 5 GLU A 164 ? SER A 177 ? GLU A 164 SER A 177 1 ? 14 HELX_P HELX_P6 6 SER A 177 ? ASP A 182 ? SER A 177 ASP A 182 1 ? 6 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 205 SG ? ? ? 1_555 A CYS 260 SG ? ? A CYS 205 A CYS 260 1_555 ? ? ? ? ? ? ? 2.022 ? covale1 covale ? ? A ASN 108 ND2 ? ? ? 1_555 B NAG . C1 ? ? A ASN 108 A NAG 310 1_555 ? ? ? ? ? ? ? 1.451 ? covale2 covale ? ? A ASN 239 ND2 ? ? ? 1_555 C NAG . C1 ? ? A ASN 239 A NAG 320 1_555 ? ? ? ? ? ? ? 1.450 ? covale3 covale ? ? C NAG . O4 ? ? ? 1_555 D NAG . C1 ? ? A NAG 320 A NAG 321 1_555 ? ? ? ? ? ? ? 1.387 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 ILE 131 A . ? ILE 131 A PRO 132 A ? PRO 132 A 1 -0.64 2 TYR 211 A . ? TYR 211 A PRO 212 A ? PRO 212 A 1 -0.02 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 8 ? B ? 4 ? C ? 4 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? anti-parallel A 2 3 ? anti-parallel A 3 4 ? anti-parallel A 4 5 ? anti-parallel A 5 6 ? anti-parallel A 6 7 ? anti-parallel A 7 8 ? anti-parallel B 1 2 ? anti-parallel B 2 3 ? anti-parallel B 3 4 ? anti-parallel C 1 2 ? anti-parallel C 2 3 ? anti-parallel C 3 4 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 GLN A 49 ? PRO A 50 ? GLN A 49 PRO A 50 A 2 LEU A 36 ? ASN A 42 ? LEU A 36 ASN A 42 A 3 PHE A 27 ? LEU A 33 ? PHE A 27 LEU A 33 A 4 ARG A 7 ? LEU A 17 ? ARG A 7 LEU A 17 A 5 VAL A 96 ? GLU A 106 ? VAL A 96 GLU A 106 A 6 ARG A 109 ? TYR A 119 ? ARG A 109 TYR A 119 A 7 LYS A 122 ? ASN A 128 ? LYS A 122 ASN A 128 A 8 ALA A 133 ? PRO A 136 ? ALA A 133 PRO A 136 B 1 SER A 188 ? GLN A 195 ? SER A 188 GLN A 195 B 2 LYS A 201 ? PHE A 210 ? LYS A 201 PHE A 210 B 3 THR A 241 ? VAL A 250 ? THR A 241 VAL A 250 B 4 LEU A 230 ? HIS A 236 ? LEU A 230 HIS A 236 C 1 GLU A 224 ? VAL A 225 ? GLU A 224 VAL A 225 C 2 ASP A 216 ? ARG A 221 ? ASP A 216 ARG A 221 C 3 TYR A 258 ? GLN A 263 ? TYR A 258 GLN A 263 C 4 LEU A 271 ? PRO A 274 ? LEU A 271 PRO A 274 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 O GLN A 49 ? O GLN A 49 N ARG A 40 ? N ARG A 40 A 2 3 O TYR A 41 ? O TYR A 41 N ALA A 29 ? N ALA A 29 A 3 4 O GLN A 28 ? O GLN A 28 N THR A 15 ? N THR A 15 A 4 5 N TYR A 12 ? N TYR A 12 O PHE A 101 ? O PHE A 101 A 5 6 N GLN A 98 ? N GLN A 98 O TYR A 118 ? O TYR A 118 A 6 7 N TYR A 117 ? N TYR A 117 O ILE A 125 ? O ILE A 125 A 7 8 N ASN A 128 ? N ASN A 128 O ALA A 133 ? O ALA A 133 B 1 2 N THR A 192 ? N THR A 192 O LYS A 204 ? O LYS A 204 B 2 3 N LYS A 201 ? N LYS A 201 O VAL A 250 ? O VAL A 250 B 3 4 O THR A 241 ? O THR A 241 N HIS A 236 ? N HIS A 236 C 1 2 O GLU A 224 ? O GLU A 224 N ARG A 221 ? N ARG A 221 C 2 3 N HIS A 218 ? N HIS A 218 O HIS A 261 ? O HIS A 261 C 3 4 N VAL A 262 ? N VAL A 262 O LEU A 271 ? O LEU A 271 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE NAG A 310' AC2 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE NAG A 320' AC3 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE NAG A 321' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 4 ASN A 108 ? ASN A 108 . ? 1_555 ? 2 AC1 4 ARG A 171 ? ARG A 171 . ? 1_555 ? 3 AC1 4 HOH E . ? HOH A 414 . ? 1_555 ? 4 AC1 4 HOH E . ? HOH A 494 . ? 1_555 ? 5 AC2 4 ASP A 209 ? ASP A 209 . ? 1_555 ? 6 AC2 4 ASN A 239 ? ASN A 239 . ? 1_555 ? 7 AC2 4 NAG D . ? NAG A 321 . ? 1_555 ? 8 AC2 4 HOH E . ? HOH A 379 . ? 1_555 ? 9 AC3 4 HIS A 236 ? HIS A 236 . ? 1_555 ? 10 AC3 4 GLN A 243 ? GLN A 243 . ? 1_555 ? 11 AC3 4 NAG C . ? NAG A 320 . ? 1_555 ? 12 AC3 4 HOH E . ? HOH A 498 . ? 1_555 ? # _atom_sites.entry_id 1T80 _atom_sites.fract_transf_matrix[1][1] 0.008160 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.008160 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.015280 _atom_sites.fract_transf_vector[1] 0.000000 _atom_sites.fract_transf_vector[2] 0.000000 _atom_sites.fract_transf_vector[3] 0.000000 # loop_ _atom_type.symbol C N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . ASP A 1 5 ? 18.473 78.725 1.539 1.00 68.43 ? 5 ASP A N 1 ATOM 2 C CA . ASP A 1 5 ? 17.784 78.919 2.845 1.00 67.64 ? 5 ASP A CA 1 ATOM 3 C C . ASP A 1 5 ? 17.853 77.649 3.684 1.00 66.10 ? 5 ASP A C 1 ATOM 4 O O . ASP A 1 5 ? 17.965 76.543 3.147 1.00 67.65 ? 5 ASP A O 1 ATOM 5 C CB . ASP A 1 5 ? 16.323 79.302 2.616 1.00 69.55 ? 5 ASP A CB 1 ATOM 6 C CG . ASP A 1 5 ? 16.174 80.611 1.865 1.00 71.56 ? 5 ASP A CG 1 ATOM 7 O OD1 . ASP A 1 5 ? 16.587 81.659 2.409 1.00 71.84 ? 5 ASP A OD1 1 ATOM 8 O OD2 . ASP A 1 5 ? 15.646 80.591 0.730 1.00 71.50 ? 5 ASP A OD2 1 ATOM 9 N N . GLY A 1 6 ? 17.788 77.814 5.001 1.00 61.90 ? 6 GLY A N 1 ATOM 10 C CA . GLY A 1 6 ? 17.847 76.671 5.890 1.00 56.24 ? 6 GLY A CA 1 ATOM 11 C C . GLY A 1 6 ? 16.563 76.468 6.669 1.00 52.66 ? 6 GLY A C 1 ATOM 12 O O . GLY A 1 6 ? 15.480 76.831 6.214 1.00 51.95 ? 6 GLY A O 1 ATOM 13 N N . ARG A 1 7 ? 16.694 75.887 7.855 1.00 49.90 ? 7 ARG A N 1 ATOM 14 C CA . ARG A 1 7 ? 15.556 75.611 8.722 1.00 46.39 ? 7 ARG A CA 1 ATOM 15 C C . ARG A 1 7 ? 15.380 76.671 9.799 1.00 41.67 ? 7 ARG A C 1 ATOM 16 O O . ARG A 1 7 ? 16.320 76.984 10.523 1.00 40.15 ? 7 ARG A O 1 ATOM 17 C CB . ARG A 1 7 ? 15.746 74.257 9.399 1.00 50.41 ? 7 ARG A CB 1 ATOM 18 C CG . ARG A 1 7 ? 15.753 73.077 8.457 1.00 56.08 ? 7 ARG A CG 1 ATOM 19 C CD . ARG A 1 7 ? 14.477 72.276 8.618 1.00 62.77 ? 7 ARG A CD 1 ATOM 20 N NE . ARG A 1 7 ? 14.274 71.850 10.001 1.00 65.65 ? 7 ARG A NE 1 ATOM 21 C CZ . ARG A 1 7 ? 13.253 71.101 10.407 1.00 68.31 ? 7 ARG A CZ 1 ATOM 22 N NH1 . ARG A 1 7 ? 12.338 70.692 9.535 1.00 69.27 ? 7 ARG A NH1 1 ATOM 23 N NH2 . ARG A 1 7 ? 13.143 70.764 11.687 1.00 67.98 ? 7 ARG A NH2 1 ATOM 24 N N . TYR A 1 8 ? 14.174 77.218 9.905 1.00 36.51 ? 8 TYR A N 1 ATOM 25 C CA . TYR A 1 8 ? 13.872 78.217 10.923 1.00 34.92 ? 8 TYR A CA 1 ATOM 26 C C . TYR A 1 8 ? 12.564 77.837 11.598 1.00 33.48 ? 8 TYR A C 1 ATOM 27 O O . TYR A 1 8 ? 11.613 77.407 10.938 1.00 32.48 ? 8 TYR A O 1 ATOM 28 C CB . TYR A 1 8 ? 13.751 79.606 10.302 1.00 36.91 ? 8 TYR A CB 1 ATOM 29 C CG . TYR A 1 8 ? 15.024 80.064 9.630 1.00 39.81 ? 8 TYR A CG 1 ATOM 30 C CD1 . TYR A 1 8 ? 16.094 80.571 10.375 1.00 38.81 ? 8 TYR A CD1 1 ATOM 31 C CD2 . TYR A 1 8 ? 15.176 79.945 8.252 1.00 39.54 ? 8 TYR A CD2 1 ATOM 32 C CE1 . TYR A 1 8 ? 17.284 80.947 9.754 1.00 39.32 ? 8 TYR A CE1 1 ATOM 33 C CE2 . TYR A 1 8 ? 16.361 80.314 7.623 1.00 40.54 ? 8 TYR A CE2 1 ATOM 34 C CZ . TYR A 1 8 ? 17.406 80.811 8.372 1.00 40.35 ? 8 TYR A CZ 1 ATOM 35 O OH . TYR A 1 8 ? 18.565 81.169 7.726 1.00 39.55 ? 8 TYR A OH 1 ATOM 36 N N . SER A 1 9 ? 12.520 77.990 12.915 1.00 30.54 ? 9 SER A N 1 ATOM 37 C CA . SER A 1 9 ? 11.322 77.647 13.665 1.00 31.35 ? 9 SER A CA 1 ATOM 38 C C . SER A 1 9 ? 10.927 78.737 14.652 1.00 30.40 ? 9 SER A C 1 ATOM 39 O O . SER A 1 9 ? 11.779 79.346 15.304 1.00 31.99 ? 9 SER A O 1 ATOM 40 C CB . SER A 1 9 ? 11.542 76.339 14.416 1.00 31.91 ? 9 SER A CB 1 ATOM 41 O OG . SER A 1 9 ? 12.524 76.512 15.421 1.00 39.69 ? 9 SER A OG 1 ATOM 42 N N . LEU A 1 10 ? 9.628 78.994 14.736 1.00 27.76 ? 10 LEU A N 1 ATOM 43 C CA . LEU A 1 10 ? 9.086 79.979 15.656 1.00 25.45 ? 10 LEU A CA 1 ATOM 44 C C . LEU A 1 10 ? 8.250 79.169 16.632 1.00 27.07 ? 10 LEU A C 1 ATOM 45 O O . LEU A 1 10 ? 7.313 78.484 16.225 1.00 25.48 ? 10 LEU A O 1 ATOM 46 C CB . LEU A 1 10 ? 8.206 80.983 14.913 1.00 24.00 ? 10 LEU A CB 1 ATOM 47 C CG . LEU A 1 10 ? 7.372 81.919 15.788 1.00 24.09 ? 10 LEU A CG 1 ATOM 48 C CD1 . LEU A 1 10 ? 8.288 82.736 16.715 1.00 24.89 ? 10 LEU A CD1 1 ATOM 49 C CD2 . LEU A 1 10 ? 6.546 82.838 14.890 1.00 25.00 ? 10 LEU A CD2 1 ATOM 50 N N . THR A 1 11 ? 8.594 79.237 17.914 1.00 27.65 ? 11 THR A N 1 ATOM 51 C CA . THR A 1 11 ? 7.884 78.465 18.935 1.00 28.53 ? 11 THR A CA 1 ATOM 52 C C . THR A 1 11 ? 7.460 79.290 20.143 1.00 28.06 ? 11 THR A C 1 ATOM 53 O O . THR A 1 11 ? 8.247 80.079 20.674 1.00 29.73 ? 11 THR A O 1 ATOM 54 C CB . THR A 1 11 ? 8.768 77.306 19.449 1.00 28.92 ? 11 THR A CB 1 ATOM 55 O OG1 . THR A 1 11 ? 9.133 76.467 18.350 1.00 32.04 ? 11 THR A OG1 1 ATOM 56 C CG2 . THR A 1 11 ? 8.020 76.472 20.492 1.00 29.03 ? 11 THR A CG2 1 ATOM 57 N N . TYR A 1 12 ? 6.214 79.101 20.568 1.00 24.72 ? 12 TYR A N 1 ATOM 58 C CA . TYR A 1 12 ? 5.684 79.793 21.734 1.00 24.94 ? 12 TYR A CA 1 ATOM 59 C C . TYR A 1 12 ? 5.265 78.775 22.781 1.00 25.68 ? 12 TYR A C 1 ATOM 60 O O . TYR A 1 12 ? 4.713 77.723 22.443 1.00 22.97 ? 12 TYR A O 1 ATOM 61 C CB . TYR A 1 12 ? 4.458 80.630 21.383 1.00 23.59 ? 12 TYR A CB 1 ATOM 62 C CG . TYR A 1 12 ? 4.705 81.718 20.368 1.00 26.63 ? 12 TYR A CG 1 ATOM 63 C CD1 . TYR A 1 12 ? 4.551 81.475 19.006 1.00 27.12 ? 12 TYR A CD1 1 ATOM 64 C CD2 . TYR A 1 12 ? 5.072 83.001 20.772 1.00 26.72 ? 12 TYR A CD2 1 ATOM 65 C CE1 . TYR A 1 12 ? 4.749 82.493 18.067 1.00 29.29 ? 12 TYR A CE1 1 ATOM 66 C CE2 . TYR A 1 12 ? 5.274 84.019 19.846 1.00 26.40 ? 12 TYR A CE2 1 ATOM 67 C CZ . TYR A 1 12 ? 5.107 83.759 18.497 1.00 28.16 ? 12 TYR A CZ 1 ATOM 68 O OH . TYR A 1 12 ? 5.273 84.768 17.579 1.00 29.31 ? 12 TYR A OH 1 ATOM 69 N N . ILE A 1 13 ? 5.525 79.089 24.047 1.00 24.06 ? 13 ILE A N 1 ATOM 70 C CA . ILE A 1 13 ? 5.132 78.210 25.145 1.00 24.36 ? 13 ILE A CA 1 ATOM 71 C C . ILE A 1 13 ? 4.441 79.026 26.240 1.00 25.77 ? 13 ILE A C 1 ATOM 72 O O . ILE A 1 13 ? 5.009 79.994 26.755 1.00 24.77 ? 13 ILE A O 1 ATOM 73 C CB . ILE A 1 13 ? 6.350 77.460 25.744 1.00 25.75 ? 13 ILE A CB 1 ATOM 74 C CG1 . ILE A 1 13 ? 7.005 76.598 24.660 1.00 28.67 ? 13 ILE A CG1 1 ATOM 75 C CG2 . ILE A 1 13 ? 5.899 76.559 26.904 1.00 21.90 ? 13 ILE A CG2 1 ATOM 76 C CD1 . ILE A 1 13 ? 8.247 75.888 25.117 1.00 33.28 ? 13 ILE A CD1 1 ATOM 77 N N . TYR A 1 14 ? 3.200 78.646 26.555 1.00 25.70 ? 14 TYR A N 1 ATOM 78 C CA . TYR A 1 14 ? 2.389 79.303 27.586 1.00 25.32 ? 14 TYR A CA 1 ATOM 79 C C . TYR A 1 14 ? 2.255 78.369 28.787 1.00 24.89 ? 14 TYR A C 1 ATOM 80 O O . TYR A 1 14 ? 2.037 77.171 28.614 1.00 23.83 ? 14 TYR A O 1 ATOM 81 C CB . TYR A 1 14 ? 0.975 79.609 27.070 1.00 25.47 ? 14 TYR A CB 1 ATOM 82 C CG . TYR A 1 14 ? 0.824 80.775 26.115 1.00 26.89 ? 14 TYR A CG 1 ATOM 83 C CD1 . TYR A 1 14 ? 1.905 81.590 25.780 1.00 28.97 ? 14 TYR A CD1 1 ATOM 84 C CD2 . TYR A 1 14 ? -0.421 81.077 25.562 1.00 28.99 ? 14 TYR A CD2 1 ATOM 85 C CE1 . TYR A 1 14 ? 1.747 82.677 24.920 1.00 29.91 ? 14 TYR A CE1 1 ATOM 86 C CE2 . TYR A 1 14 ? -0.590 82.163 24.700 1.00 30.75 ? 14 TYR A CE2 1 ATOM 87 C CZ . TYR A 1 14 ? 0.499 82.958 24.387 1.00 31.01 ? 14 TYR A CZ 1 ATOM 88 O OH . TYR A 1 14 ? 0.333 84.047 23.561 1.00 33.92 ? 14 TYR A OH 1 ATOM 89 N N . THR A 1 15 ? 2.368 78.923 29.994 1.00 24.22 ? 15 THR A N 1 ATOM 90 C CA . THR A 1 15 ? 2.263 78.152 31.232 1.00 23.66 ? 15 THR A CA 1 ATOM 91 C C . THR A 1 15 ? 1.339 78.870 32.211 1.00 25.84 ? 15 THR A C 1 ATOM 92 O O . THR A 1 15 ? 1.570 80.033 32.558 1.00 24.66 ? 15 THR A O 1 ATOM 93 C CB . THR A 1 15 ? 3.627 78.008 31.919 1.00 26.60 ? 15 THR A CB 1 ATOM 94 O OG1 . THR A 1 15 ? 4.561 77.439 31.002 1.00 24.83 ? 15 THR A OG1 1 ATOM 95 C CG2 . THR A 1 15 ? 3.513 77.114 33.163 1.00 26.61 ? 15 THR A CG2 1 ATOM 96 N N . GLY A 1 16 ? 0.298 78.176 32.655 1.00 24.47 ? 16 GLY A N 1 ATOM 97 C CA . GLY A 1 16 ? -0.641 78.768 33.588 1.00 23.96 ? 16 GLY A CA 1 ATOM 98 C C . GLY A 1 16 ? -0.783 77.884 34.808 1.00 25.63 ? 16 GLY A C 1 ATOM 99 O O . GLY A 1 16 ? -0.775 76.660 34.685 1.00 24.18 ? 16 GLY A O 1 ATOM 100 N N . LEU A 1 17 ? -0.892 78.503 35.983 1.00 26.55 ? 17 LEU A N 1 ATOM 101 C CA . LEU A 1 17 ? -1.037 77.775 37.246 1.00 28.39 ? 17 LEU A CA 1 ATOM 102 C C . LEU A 1 17 ? -2.366 78.183 37.865 1.00 29.41 ? 17 LEU A C 1 ATOM 103 O O . LEU A 1 17 ? -2.657 79.373 37.950 1.00 28.25 ? 17 LEU A O 1 ATOM 104 C CB . LEU A 1 17 ? 0.120 78.133 38.184 1.00 27.75 ? 17 LEU A CB 1 ATOM 105 C CG . LEU A 1 17 ? 1.491 77.703 37.660 1.00 28.59 ? 17 LEU A CG 1 ATOM 106 C CD1 . LEU A 1 17 ? 2.607 78.385 38.432 1.00 28.70 ? 17 LEU A CD1 1 ATOM 107 C CD2 . LEU A 1 17 ? 1.603 76.189 37.753 1.00 26.49 ? 17 LEU A CD2 1 ATOM 108 N N . SER A 1 18 ? -3.177 77.211 38.283 1.00 30.96 ? 18 SER A N 1 ATOM 109 C CA . SER A 1 18 ? -4.482 77.534 38.862 1.00 32.64 ? 18 SER A CA 1 ATOM 110 C C . SER A 1 18 ? -4.369 78.146 40.253 1.00 35.24 ? 18 SER A C 1 ATOM 111 O O . SER A 1 18 ? -5.228 78.925 40.659 1.00 35.00 ? 18 SER A O 1 ATOM 112 C CB . SER A 1 18 ? -5.387 76.295 38.914 1.00 32.32 ? 18 SER A CB 1 ATOM 113 O OG . SER A 1 18 ? -4.879 75.306 39.795 1.00 33.38 ? 18 SER A OG 1 ATOM 114 N N . LYS A 1 19 ? -3.317 77.787 40.981 1.00 35.23 ? 19 LYS A N 1 ATOM 115 C CA . LYS A 1 19 ? -3.095 78.327 42.323 1.00 36.73 ? 19 LYS A CA 1 ATOM 116 C C . LYS A 1 19 ? -1.600 78.582 42.497 1.00 34.80 ? 19 LYS A C 1 ATOM 117 O O . LYS A 1 19 ? -0.879 77.770 43.066 1.00 35.14 ? 19 LYS A O 1 ATOM 118 C CB . LYS A 1 19 ? -3.600 77.344 43.390 1.00 37.50 ? 19 LYS A CB 1 ATOM 119 C CG . LYS A 1 19 ? -3.510 77.884 44.813 1.00 43.80 ? 19 LYS A CG 1 ATOM 120 C CD . LYS A 1 19 ? -3.950 76.863 45.862 1.00 46.81 ? 19 LYS A CD 1 ATOM 121 C CE . LYS A 1 19 ? -5.459 76.780 45.979 1.00 48.95 ? 19 LYS A CE 1 ATOM 122 N NZ . LYS A 1 19 ? -6.107 76.337 44.718 1.00 52.40 ? 19 LYS A NZ 1 ATOM 123 N N . HIS A 1 20 ? -1.137 79.719 41.994 1.00 36.00 ? 20 HIS A N 1 ATOM 124 C CA . HIS A 1 20 ? 0.276 80.053 42.065 1.00 36.51 ? 20 HIS A CA 1 ATOM 125 C C . HIS A 1 20 ? 0.697 80.434 43.472 1.00 36.85 ? 20 HIS A C 1 ATOM 126 O O . HIS A 1 20 ? -0.073 81.020 44.228 1.00 36.36 ? 20 HIS A O 1 ATOM 127 C CB . HIS A 1 20 ? 0.599 81.195 41.096 1.00 37.10 ? 20 HIS A CB 1 ATOM 128 C CG . HIS A 1 20 ? 0.168 82.546 41.576 1.00 39.43 ? 20 HIS A CG 1 ATOM 129 N ND1 . HIS A 1 20 ? 0.898 83.280 42.487 1.00 42.73 ? 20 HIS A ND1 1 ATOM 130 C CD2 . HIS A 1 20 ? -0.919 83.296 41.274 1.00 41.11 ? 20 HIS A CD2 1 ATOM 131 C CE1 . HIS A 1 20 ? 0.281 84.424 42.723 1.00 42.46 ? 20 HIS A CE1 1 ATOM 132 N NE2 . HIS A 1 20 ? -0.824 84.459 42.000 1.00 42.34 ? 20 HIS A NE2 1 ATOM 133 N N . VAL A 1 21 ? 1.928 80.088 43.814 1.00 36.65 ? 21 VAL A N 1 ATOM 134 C CA . VAL A 1 21 ? 2.472 80.405 45.124 1.00 37.34 ? 21 VAL A CA 1 ATOM 135 C C . VAL A 1 21 ? 3.204 81.741 45.030 1.00 39.64 ? 21 VAL A C 1 ATOM 136 O O . VAL A 1 21 ? 3.421 82.263 43.933 1.00 37.21 ? 21 VAL A O 1 ATOM 137 C CB . VAL A 1 21 ? 3.447 79.313 45.591 1.00 35.18 ? 21 VAL A CB 1 ATOM 138 C CG1 . VAL A 1 21 ? 2.727 77.976 45.651 1.00 32.50 ? 21 VAL A CG1 1 ATOM 139 C CG2 . VAL A 1 21 ? 4.632 79.232 44.645 1.00 36.06 ? 21 VAL A CG2 1 ATOM 140 N N . GLU A 1 22 ? 3.581 82.285 46.183 1.00 42.07 ? 22 GLU A N 1 ATOM 141 C CA . GLU A 1 22 ? 4.275 83.568 46.260 1.00 44.63 ? 22 GLU A CA 1 ATOM 142 C C . GLU A 1 22 ? 5.475 83.686 45.320 1.00 42.45 ? 22 GLU A C 1 ATOM 143 O O . GLU A 1 22 ? 6.323 82.801 45.266 1.00 43.37 ? 22 GLU A O 1 ATOM 144 C CB . GLU A 1 22 ? 4.753 83.812 47.697 1.00 49.15 ? 22 GLU A CB 1 ATOM 145 C CG . GLU A 1 22 ? 3.697 83.575 48.777 1.00 58.06 ? 22 GLU A CG 1 ATOM 146 C CD . GLU A 1 22 ? 2.676 84.697 48.882 1.00 62.59 ? 22 GLU A CD 1 ATOM 147 O OE1 . GLU A 1 22 ? 3.080 85.849 49.155 1.00 66.73 ? 22 GLU A OE1 1 ATOM 148 O OE2 . GLU A 1 22 ? 1.468 84.427 48.703 1.00 65.60 ? 22 GLU A OE2 1 ATOM 149 N N . ASP A 1 23 ? 5.539 84.791 44.585 1.00 40.91 ? 23 ASP A N 1 ATOM 150 C CA . ASP A 1 23 ? 6.646 85.064 43.673 1.00 40.82 ? 23 ASP A CA 1 ATOM 151 C C . ASP A 1 23 ? 6.671 84.261 42.375 1.00 39.18 ? 23 ASP A C 1 ATOM 152 O O . ASP A 1 23 ? 7.634 84.335 41.612 1.00 38.99 ? 23 ASP A O 1 ATOM 153 C CB . ASP A 1 23 ? 7.982 84.907 44.407 1.00 44.71 ? 23 ASP A CB 1 ATOM 154 C CG . ASP A 1 23 ? 8.115 85.869 45.584 1.00 50.63 ? 23 ASP A CG 1 ATOM 155 O OD1 . ASP A 1 23 ? 7.901 87.088 45.384 1.00 50.56 ? 23 ASP A OD1 1 ATOM 156 O OD2 . ASP A 1 23 ? 8.432 85.408 46.705 1.00 50.93 ? 23 ASP A OD2 1 ATOM 157 N N . VAL A 1 24 ? 5.626 83.484 42.125 1.00 36.69 ? 24 VAL A N 1 ATOM 158 C CA . VAL A 1 24 ? 5.548 82.735 40.878 1.00 33.07 ? 24 VAL A CA 1 ATOM 159 C C . VAL A 1 24 ? 4.321 83.252 40.148 1.00 29.74 ? 24 VAL A C 1 ATOM 160 O O . VAL A 1 24 ? 3.208 83.146 40.643 1.00 29.71 ? 24 VAL A O 1 ATOM 161 C CB . VAL A 1 24 ? 5.400 81.219 41.107 1.00 32.37 ? 24 VAL A CB 1 ATOM 162 C CG1 . VAL A 1 24 ? 5.295 80.498 39.758 1.00 32.67 ? 24 VAL A CG1 1 ATOM 163 C CG2 . VAL A 1 24 ? 6.595 80.694 41.884 1.00 32.71 ? 24 VAL A CG2 1 ATOM 164 N N . PRO A 1 25 ? 4.514 83.851 38.969 1.00 30.85 ? 25 PRO A N 1 ATOM 165 C CA . PRO A 1 25 ? 3.378 84.375 38.207 1.00 30.88 ? 25 PRO A CA 1 ATOM 166 C C . PRO A 1 25 ? 2.424 83.272 37.776 1.00 29.71 ? 25 PRO A C 1 ATOM 167 O O . PRO A 1 25 ? 2.851 82.176 37.421 1.00 31.17 ? 25 PRO A O 1 ATOM 168 C CB . PRO A 1 25 ? 4.045 85.086 37.028 1.00 31.54 ? 25 PRO A CB 1 ATOM 169 C CG . PRO A 1 25 ? 5.337 84.361 36.873 1.00 35.98 ? 25 PRO A CG 1 ATOM 170 C CD . PRO A 1 25 ? 5.788 84.148 38.292 1.00 32.67 ? 25 PRO A CD 1 ATOM 171 N N . ALA A 1 26 ? 1.129 83.560 37.827 1.00 28.85 ? 26 ALA A N 1 ATOM 172 C CA . ALA A 1 26 ? 0.125 82.577 37.450 1.00 29.03 ? 26 ALA A CA 1 ATOM 173 C C . ALA A 1 26 ? 0.250 82.192 35.977 1.00 27.89 ? 26 ALA A C 1 ATOM 174 O O . ALA A 1 26 ? 0.008 81.046 35.606 1.00 28.85 ? 26 ALA A O 1 ATOM 175 C CB . ALA A 1 26 ? -1.266 83.122 37.726 1.00 26.30 ? 26 ALA A CB 1 ATOM 176 N N . PHE A 1 27 ? 0.641 83.151 35.146 1.00 27.04 ? 27 PHE A N 1 ATOM 177 C CA . PHE A 1 27 ? 0.768 82.909 33.713 1.00 26.73 ? 27 PHE A CA 1 ATOM 178 C C . PHE A 1 27 ? 2.094 83.415 33.179 1.00 27.20 ? 27 PHE A C 1 ATOM 179 O O . PHE A 1 27 ? 2.489 84.550 33.452 1.00 28.02 ? 27 PHE A O 1 ATOM 180 C CB . PHE A 1 27 ? -0.378 83.599 32.963 1.00 25.42 ? 27 PHE A CB 1 ATOM 181 C CG . PHE A 1 27 ? -0.282 83.488 31.467 1.00 25.91 ? 27 PHE A CG 1 ATOM 182 C CD1 . PHE A 1 27 ? -0.832 82.399 30.798 1.00 24.97 ? 27 PHE A CD1 1 ATOM 183 C CD2 . PHE A 1 27 ? 0.357 84.479 30.722 1.00 25.24 ? 27 PHE A CD2 1 ATOM 184 C CE1 . PHE A 1 27 ? -0.752 82.300 29.403 1.00 25.64 ? 27 PHE A CE1 1 ATOM 185 C CE2 . PHE A 1 27 ? 0.441 84.391 29.331 1.00 26.20 ? 27 PHE A CE2 1 ATOM 186 C CZ . PHE A 1 27 ? -0.116 83.299 28.671 1.00 24.52 ? 27 PHE A CZ 1 ATOM 187 N N . GLN A 1 28 ? 2.776 82.570 32.411 1.00 25.87 ? 28 GLN A N 1 ATOM 188 C CA . GLN A 1 28 ? 4.056 82.928 31.826 1.00 28.10 ? 28 GLN A CA 1 ATOM 189 C C . GLN A 1 28 ? 4.080 82.513 30.364 1.00 29.10 ? 28 GLN A C 1 ATOM 190 O O . GLN A 1 28 ? 3.479 81.508 29.986 1.00 28.60 ? 28 GLN A O 1 ATOM 191 C CB . GLN A 1 28 ? 5.204 82.244 32.588 1.00 32.19 ? 28 GLN A CB 1 ATOM 192 C CG . GLN A 1 28 ? 5.429 82.808 33.992 1.00 37.28 ? 28 GLN A CG 1 ATOM 193 C CD . GLN A 1 28 ? 6.474 82.043 34.796 1.00 40.84 ? 28 GLN A CD 1 ATOM 194 O OE1 . GLN A 1 28 ? 6.192 80.981 35.359 1.00 45.10 ? 28 GLN A OE1 1 ATOM 195 N NE2 . GLN A 1 28 ? 7.684 82.583 34.854 1.00 42.15 ? 28 GLN A NE2 1 ATOM 196 N N . ALA A 1 29 ? 4.781 83.291 29.546 1.00 28.19 ? 29 ALA A N 1 ATOM 197 C CA . ALA A 1 29 ? 4.888 83.015 28.123 1.00 27.92 ? 29 ALA A CA 1 ATOM 198 C C . ALA A 1 29 ? 6.287 83.311 27.631 1.00 28.29 ? 29 ALA A C 1 ATOM 199 O O . ALA A 1 29 ? 6.953 84.219 28.124 1.00 28.06 ? 29 ALA A O 1 ATOM 200 C CB . ALA A 1 29 ? 3.893 83.865 27.352 1.00 28.39 ? 29 ALA A CB 1 ATOM 201 N N . LEU A 1 30 ? 6.732 82.540 26.653 1.00 25.57 ? 30 LEU A N 1 ATOM 202 C CA . LEU A 1 30 ? 8.041 82.758 26.080 1.00 26.89 ? 30 LEU A CA 1 ATOM 203 C C . LEU A 1 30 ? 7.999 82.365 24.616 1.00 26.47 ? 30 LEU A C 1 ATOM 204 O O . LEU A 1 30 ? 7.112 81.615 24.192 1.00 25.77 ? 30 LEU A O 1 ATOM 205 C CB . LEU A 1 30 ? 9.108 81.955 26.840 1.00 30.09 ? 30 LEU A CB 1 ATOM 206 C CG . LEU A 1 30 ? 8.959 80.440 27.000 1.00 32.47 ? 30 LEU A CG 1 ATOM 207 C CD1 . LEU A 1 30 ? 9.373 79.744 25.720 1.00 35.31 ? 30 LEU A CD1 1 ATOM 208 C CD2 . LEU A 1 30 ? 9.837 79.964 28.154 1.00 33.62 ? 30 LEU A CD2 1 ATOM 209 N N . GLY A 1 31 ? 8.945 82.893 23.847 1.00 24.49 ? 31 GLY A N 1 ATOM 210 C CA . GLY A 1 31 ? 9.009 82.587 22.432 1.00 25.45 ? 31 GLY A CA 1 ATOM 211 C C . GLY A 1 31 ? 10.443 82.394 21.990 1.00 26.66 ? 31 GLY A C 1 ATOM 212 O O . GLY A 1 31 ? 11.346 83.107 22.446 1.00 27.50 ? 31 GLY A O 1 ATOM 213 N N . SER A 1 32 ? 10.653 81.434 21.098 1.00 26.01 ? 32 SER A N 1 ATOM 214 C CA . SER A 1 32 ? 11.981 81.134 20.600 1.00 28.09 ? 32 SER A CA 1 ATOM 215 C C . SER A 1 32 ? 12.053 81.088 19.088 1.00 28.53 ? 32 SER A C 1 ATOM 216 O O . SER A 1 32 ? 11.085 80.732 18.418 1.00 26.61 ? 32 SER A O 1 ATOM 217 C CB . SER A 1 32 ? 12.454 79.783 21.134 1.00 28.86 ? 32 SER A CB 1 ATOM 218 O OG . SER A 1 32 ? 12.384 79.753 22.541 1.00 37.17 ? 32 SER A OG 1 ATOM 219 N N . LEU A 1 33 ? 13.221 81.463 18.573 1.00 27.98 ? 33 LEU A N 1 ATOM 220 C CA . LEU A 1 33 ? 13.520 81.424 17.146 1.00 29.55 ? 33 LEU A CA 1 ATOM 221 C C . LEU A 1 33 ? 14.712 80.482 17.132 1.00 28.70 ? 33 LEU A C 1 ATOM 222 O O . LEU A 1 33 ? 15.779 80.806 17.662 1.00 28.91 ? 33 LEU A O 1 ATOM 223 C CB . LEU A 1 33 ? 13.896 82.818 16.627 1.00 28.02 ? 33 LEU A CB 1 ATOM 224 C CG . LEU A 1 33 ? 12.683 83.727 16.382 1.00 29.31 ? 33 LEU A CG 1 ATOM 225 C CD1 . LEU A 1 33 ? 13.117 85.170 16.177 1.00 30.49 ? 33 LEU A CD1 1 ATOM 226 C CD2 . LEU A 1 33 ? 11.922 83.220 15.160 1.00 29.74 ? 33 LEU A CD2 1 ATOM 227 N N . ASN A 1 34 ? 14.519 79.306 16.550 1.00 28.95 ? 34 ASN A N 1 ATOM 228 C CA . ASN A 1 34 ? 15.556 78.288 16.529 1.00 30.45 ? 34 ASN A CA 1 ATOM 229 C C . ASN A 1 34 ? 15.959 77.984 17.976 1.00 30.19 ? 34 ASN A C 1 ATOM 230 O O . ASN A 1 34 ? 15.100 77.720 18.812 1.00 28.35 ? 34 ASN A O 1 ATOM 231 C CB . ASN A 1 34 ? 16.760 78.747 15.692 1.00 32.15 ? 34 ASN A CB 1 ATOM 232 C CG . ASN A 1 34 ? 16.494 78.645 14.193 1.00 35.62 ? 34 ASN A CG 1 ATOM 233 O OD1 . ASN A 1 34 ? 15.380 78.326 13.773 1.00 34.74 ? 34 ASN A OD1 1 ATOM 234 N ND2 . ASN A 1 34 ? 17.513 78.915 13.383 1.00 34.60 ? 34 ASN A ND2 1 ATOM 235 N N . ASP A 1 35 ? 17.249 78.063 18.279 1.00 29.37 ? 35 ASP A N 1 ATOM 236 C CA . ASP A 1 35 ? 17.743 77.750 19.616 1.00 29.14 ? 35 ASP A CA 1 ATOM 237 C C . ASP A 1 35 ? 17.766 78.903 20.618 1.00 29.14 ? 35 ASP A C 1 ATOM 238 O O . ASP A 1 35 ? 18.203 78.722 21.756 1.00 28.99 ? 35 ASP A O 1 ATOM 239 C CB . ASP A 1 35 ? 19.147 77.156 19.493 1.00 30.31 ? 35 ASP A CB 1 ATOM 240 C CG . ASP A 1 35 ? 20.137 78.114 18.818 1.00 33.96 ? 35 ASP A CG 1 ATOM 241 O OD1 . ASP A 1 35 ? 19.710 78.937 17.974 1.00 29.92 ? 35 ASP A OD1 1 ATOM 242 O OD2 . ASP A 1 35 ? 21.345 78.029 19.124 1.00 33.01 ? 35 ASP A OD2 1 ATOM 243 N N . LEU A 1 36 ? 17.279 80.074 20.216 1.00 28.41 ? 36 LEU A N 1 ATOM 244 C CA . LEU A 1 36 ? 17.305 81.242 21.091 1.00 28.48 ? 36 LEU A CA 1 ATOM 245 C C . LEU A 1 36 ? 15.936 81.778 21.503 1.00 29.23 ? 36 LEU A C 1 ATOM 246 O O . LEU A 1 36 ? 14.985 81.746 20.723 1.00 29.58 ? 36 LEU A O 1 ATOM 247 C CB . LEU A 1 36 ? 18.096 82.373 20.413 1.00 27.17 ? 36 LEU A CB 1 ATOM 248 C CG . LEU A 1 36 ? 19.510 82.061 19.911 1.00 28.60 ? 36 LEU A CG 1 ATOM 249 C CD1 . LEU A 1 36 ? 20.048 83.246 19.112 1.00 26.54 ? 36 LEU A CD1 1 ATOM 250 C CD2 . LEU A 1 36 ? 20.428 81.737 21.087 1.00 26.15 ? 36 LEU A CD2 1 ATOM 251 N N . GLN A 1 37 ? 15.846 82.278 22.733 1.00 27.84 ? 37 GLN A N 1 ATOM 252 C CA . GLN A 1 37 ? 14.604 82.860 23.225 1.00 29.54 ? 37 GLN A CA 1 ATOM 253 C C . GLN A 1 37 ? 14.639 84.351 22.896 1.00 29.15 ? 37 GLN A C 1 ATOM 254 O O . GLN A 1 37 ? 15.604 85.043 23.219 1.00 29.77 ? 37 GLN A O 1 ATOM 255 C CB . GLN A 1 37 ? 14.460 82.653 24.737 1.00 29.94 ? 37 GLN A CB 1 ATOM 256 C CG . GLN A 1 37 ? 13.257 83.377 25.321 1.00 33.78 ? 37 GLN A CG 1 ATOM 257 C CD . GLN A 1 37 ? 12.884 82.912 26.720 1.00 36.66 ? 37 GLN A CD 1 ATOM 258 O OE1 . GLN A 1 37 ? 12.143 83.591 27.432 1.00 38.06 ? 37 GLN A OE1 1 ATOM 259 N NE2 . GLN A 1 37 ? 13.376 81.747 27.111 1.00 37.61 ? 37 GLN A NE2 1 ATOM 260 N N . PHE A 1 38 ? 13.586 84.848 22.259 1.00 29.29 ? 38 PHE A N 1 ATOM 261 C CA . PHE A 1 38 ? 13.552 86.251 21.866 1.00 29.13 ? 38 PHE A CA 1 ATOM 262 C C . PHE A 1 38 ? 12.602 87.134 22.666 1.00 28.98 ? 38 PHE A C 1 ATOM 263 O O . PHE A 1 38 ? 12.649 88.353 22.536 1.00 29.96 ? 38 PHE A O 1 ATOM 264 C CB . PHE A 1 38 ? 13.241 86.362 20.364 1.00 29.14 ? 38 PHE A CB 1 ATOM 265 C CG . PHE A 1 38 ? 11.806 86.044 20.002 1.00 28.52 ? 38 PHE A CG 1 ATOM 266 C CD1 . PHE A 1 38 ? 10.831 87.035 20.028 1.00 26.96 ? 38 PHE A CD1 1 ATOM 267 C CD2 . PHE A 1 38 ? 11.438 84.755 19.633 1.00 26.43 ? 38 PHE A CD2 1 ATOM 268 C CE1 . PHE A 1 38 ? 9.501 86.750 19.689 1.00 28.14 ? 38 PHE A CE1 1 ATOM 269 C CE2 . PHE A 1 38 ? 10.118 84.457 19.292 1.00 27.98 ? 38 PHE A CE2 1 ATOM 270 C CZ . PHE A 1 38 ? 9.143 85.461 19.321 1.00 27.64 ? 38 PHE A CZ 1 ATOM 271 N N . PHE A 1 39 ? 11.744 86.538 23.492 1.00 27.18 ? 39 PHE A N 1 ATOM 272 C CA . PHE A 1 39 ? 10.824 87.341 24.294 1.00 27.81 ? 39 PHE A CA 1 ATOM 273 C C . PHE A 1 39 ? 10.195 86.566 25.443 1.00 28.20 ? 39 PHE A C 1 ATOM 274 O O . PHE A 1 39 ? 10.246 85.337 25.494 1.00 26.60 ? 39 PHE A O 1 ATOM 275 C CB . PHE A 1 39 ? 9.712 87.942 23.411 1.00 30.03 ? 39 PHE A CB 1 ATOM 276 C CG . PHE A 1 39 ? 8.368 87.265 23.563 1.00 30.11 ? 39 PHE A CG 1 ATOM 277 C CD1 . PHE A 1 39 ? 8.136 86.009 23.011 1.00 29.07 ? 39 PHE A CD1 1 ATOM 278 C CD2 . PHE A 1 39 ? 7.349 87.872 24.296 1.00 30.33 ? 39 PHE A CD2 1 ATOM 279 C CE1 . PHE A 1 39 ? 6.905 85.357 23.188 1.00 29.45 ? 39 PHE A CE1 1 ATOM 280 C CE2 . PHE A 1 39 ? 6.109 87.228 24.480 1.00 32.43 ? 39 PHE A CE2 1 ATOM 281 C CZ . PHE A 1 39 ? 5.892 85.968 23.925 1.00 28.98 ? 39 PHE A CZ 1 ATOM 282 N N . ARG A 1 40 ? 9.598 87.301 26.371 1.00 29.41 ? 40 ARG A N 1 ATOM 283 C CA . ARG A 1 40 ? 8.938 86.691 27.509 1.00 31.36 ? 40 ARG A CA 1 ATOM 284 C C . ARG A 1 40 ? 7.849 87.637 27.982 1.00 30.03 ? 40 ARG A C 1 ATOM 285 O O . ARG A 1 40 ? 7.854 88.818 27.647 1.00 30.15 ? 40 ARG A O 1 ATOM 286 C CB . ARG A 1 40 ? 9.932 86.457 28.643 1.00 35.06 ? 40 ARG A CB 1 ATOM 287 C CG . ARG A 1 40 ? 10.403 87.744 29.290 1.00 40.73 ? 40 ARG A CG 1 ATOM 288 C CD . ARG A 1 40 ? 11.425 87.496 30.389 1.00 46.30 ? 40 ARG A CD 1 ATOM 289 N NE . ARG A 1 40 ? 11.774 88.750 31.048 1.00 52.26 ? 40 ARG A NE 1 ATOM 290 C CZ . ARG A 1 40 ? 12.692 88.867 32.000 1.00 55.96 ? 40 ARG A CZ 1 ATOM 291 N NH1 . ARG A 1 40 ? 13.365 87.800 32.415 1.00 56.98 ? 40 ARG A NH1 1 ATOM 292 N NH2 . ARG A 1 40 ? 12.939 90.055 32.535 1.00 57.18 ? 40 ARG A NH2 1 ATOM 293 N N . TYR A 1 41 ? 6.928 87.107 28.774 1.00 28.40 ? 41 TYR A N 1 ATOM 294 C CA . TYR A 1 41 ? 5.820 87.876 29.314 1.00 28.84 ? 41 TYR A CA 1 ATOM 295 C C . TYR A 1 41 ? 5.236 87.083 30.469 1.00 29.60 ? 41 TYR A C 1 ATOM 296 O O . TYR A 1 41 ? 5.169 85.857 30.410 1.00 28.96 ? 41 TYR A O 1 ATOM 297 C CB . TYR A 1 41 ? 4.741 88.089 28.233 1.00 28.73 ? 41 TYR A CB 1 ATOM 298 C CG . TYR A 1 41 ? 3.389 88.542 28.764 1.00 29.23 ? 41 TYR A CG 1 ATOM 299 C CD1 . TYR A 1 41 ? 2.501 87.631 29.343 1.00 27.61 ? 41 TYR A CD1 1 ATOM 300 C CD2 . TYR A 1 41 ? 2.999 89.883 28.695 1.00 29.65 ? 41 TYR A CD2 1 ATOM 301 C CE1 . TYR A 1 41 ? 1.267 88.036 29.836 1.00 26.44 ? 41 TYR A CE1 1 ATOM 302 C CE2 . TYR A 1 41 ? 1.760 90.298 29.185 1.00 28.13 ? 41 TYR A CE2 1 ATOM 303 C CZ . TYR A 1 41 ? 0.900 89.368 29.753 1.00 29.67 ? 41 TYR A CZ 1 ATOM 304 O OH . TYR A 1 41 ? -0.333 89.766 30.226 1.00 31.71 ? 41 TYR A OH 1 ATOM 305 N N . ASN A 1 42 ? 4.822 87.770 31.525 1.00 29.01 ? 42 ASN A N 1 ATOM 306 C CA . ASN A 1 42 ? 4.214 87.077 32.647 1.00 29.64 ? 42 ASN A CA 1 ATOM 307 C C . ASN A 1 42 ? 3.099 87.943 33.212 1.00 29.25 ? 42 ASN A C 1 ATOM 308 O O . ASN A 1 42 ? 3.052 89.142 32.957 1.00 29.43 ? 42 ASN A O 1 ATOM 309 C CB . ASN A 1 42 ? 5.267 86.727 33.710 1.00 29.48 ? 42 ASN A CB 1 ATOM 310 C CG . ASN A 1 42 ? 5.812 87.940 34.426 1.00 32.77 ? 42 ASN A CG 1 ATOM 311 O OD1 . ASN A 1 42 ? 5.090 88.629 35.148 1.00 32.46 ? 42 ASN A OD1 1 ATOM 312 N ND2 . ASN A 1 42 ? 7.095 88.206 34.235 1.00 33.80 ? 42 ASN A ND2 1 ATOM 313 N N . SER A 1 43 ? 2.190 87.330 33.959 1.00 30.30 ? 43 SER A N 1 ATOM 314 C CA . SER A 1 43 ? 1.057 88.039 34.529 1.00 31.79 ? 43 SER A CA 1 ATOM 315 C C . SER A 1 43 ? 1.385 89.027 35.648 1.00 34.79 ? 43 SER A C 1 ATOM 316 O O . SER A 1 43 ? 0.498 89.727 36.125 1.00 34.69 ? 43 SER A O 1 ATOM 317 C CB . SER A 1 43 ? 0.024 87.029 35.029 1.00 32.54 ? 43 SER A CB 1 ATOM 318 O OG . SER A 1 43 ? 0.632 86.091 35.892 1.00 34.10 ? 43 SER A OG 1 ATOM 319 N N . LYS A 1 44 ? 2.646 89.084 36.069 1.00 37.16 ? 44 LYS A N 1 ATOM 320 C CA . LYS A 1 44 ? 3.046 90.009 37.124 1.00 41.64 ? 44 LYS A CA 1 ATOM 321 C C . LYS A 1 44 ? 3.328 91.390 36.536 1.00 42.68 ? 44 LYS A C 1 ATOM 322 O O . LYS A 1 44 ? 2.677 92.372 36.891 1.00 42.25 ? 44 LYS A O 1 ATOM 323 C CB . LYS A 1 44 ? 4.300 89.503 37.842 1.00 45.01 ? 44 LYS A CB 1 ATOM 324 C CG . LYS A 1 44 ? 4.746 90.400 38.987 1.00 49.52 ? 44 LYS A CG 1 ATOM 325 C CD . LYS A 1 44 ? 6.119 90.004 39.510 1.00 52.64 ? 44 LYS A CD 1 ATOM 326 C CE . LYS A 1 44 ? 6.607 90.993 40.567 1.00 55.37 ? 44 LYS A CE 1 ATOM 327 N NZ . LYS A 1 44 ? 7.973 90.667 41.076 1.00 55.62 ? 44 LYS A NZ 1 ATOM 328 N N . ASP A 1 45 ? 4.301 91.455 35.633 1.00 43.63 ? 45 ASP A N 1 ATOM 329 C CA . ASP A 1 45 ? 4.669 92.710 34.994 1.00 44.89 ? 45 ASP A CA 1 ATOM 330 C C . ASP A 1 45 ? 3.697 93.053 33.871 1.00 44.96 ? 45 ASP A C 1 ATOM 331 O O . ASP A 1 45 ? 3.465 94.228 33.575 1.00 44.37 ? 45 ASP A O 1 ATOM 332 C CB . ASP A 1 45 ? 6.094 92.622 34.456 1.00 47.47 ? 45 ASP A CB 1 ATOM 333 C CG . ASP A 1 45 ? 7.091 92.229 35.527 1.00 50.95 ? 45 ASP A CG 1 ATOM 334 O OD1 . ASP A 1 45 ? 7.005 92.783 36.644 1.00 52.01 ? 45 ASP A OD1 1 ATOM 335 O OD2 . ASP A 1 45 ? 7.961 91.371 35.258 1.00 53.84 ? 45 ASP A OD2 1 ATOM 336 N N . ARG A 1 46 ? 3.143 92.022 33.239 1.00 43.49 ? 46 ARG A N 1 ATOM 337 C CA . ARG A 1 46 ? 2.171 92.212 32.171 1.00 43.40 ? 46 ARG A CA 1 ATOM 338 C C . ARG A 1 46 ? 2.758 92.891 30.933 1.00 42.09 ? 46 ARG A C 1 ATOM 339 O O . ARG A 1 46 ? 2.044 93.591 30.223 1.00 41.99 ? 46 ARG A O 1 ATOM 340 C CB . ARG A 1 46 ? 1.005 93.056 32.692 1.00 45.45 ? 46 ARG A CB 1 ATOM 341 C CG . ARG A 1 46 ? -0.380 92.479 32.469 1.00 51.14 ? 46 ARG A CG 1 ATOM 342 C CD . ARG A 1 46 ? -0.765 91.479 33.547 1.00 52.61 ? 46 ARG A CD 1 ATOM 343 N NE . ARG A 1 46 ? -2.160 91.068 33.416 1.00 55.16 ? 46 ARG A NE 1 ATOM 344 C CZ . ARG A 1 46 ? -2.766 90.198 34.220 1.00 57.27 ? 46 ARG A CZ 1 ATOM 345 N NH1 . ARG A 1 46 ? -2.106 89.636 35.222 1.00 55.61 ? 46 ARG A NH1 1 ATOM 346 N NH2 . ARG A 1 46 ? -4.040 89.887 34.022 1.00 60.19 ? 46 ARG A NH2 1 ATOM 347 N N . LYS A 1 47 ? 4.043 92.686 30.664 1.00 41.55 ? 47 LYS A N 1 ATOM 348 C CA . LYS A 1 47 ? 4.667 93.311 29.501 1.00 41.56 ? 47 LYS A CA 1 ATOM 349 C C . LYS A 1 47 ? 5.493 92.353 28.641 1.00 40.80 ? 47 LYS A C 1 ATOM 350 O O . LYS A 1 47 ? 6.299 91.583 29.159 1.00 39.08 ? 47 LYS A O 1 ATOM 351 C CB . LYS A 1 47 ? 5.547 94.484 29.952 1.00 43.98 ? 47 LYS A CB 1 ATOM 352 C CG . LYS A 1 47 ? 4.783 95.547 30.743 1.00 48.61 ? 47 LYS A CG 1 ATOM 353 C CD . LYS A 1 47 ? 3.546 96.007 29.972 1.00 52.21 ? 47 LYS A CD 1 ATOM 354 C CE . LYS A 1 47 ? 2.531 96.689 30.881 1.00 55.10 ? 47 LYS A CE 1 ATOM 355 N NZ . LYS A 1 47 ? 1.216 96.860 30.199 1.00 55.72 ? 47 LYS A NZ 1 ATOM 356 N N . SER A 1 48 ? 5.282 92.393 27.328 1.00 38.55 ? 48 SER A N 1 ATOM 357 C CA . SER A 1 48 ? 6.045 91.537 26.423 1.00 39.22 ? 48 SER A CA 1 ATOM 358 C C . SER A 1 48 ? 7.393 92.213 26.270 1.00 39.09 ? 48 SER A C 1 ATOM 359 O O . SER A 1 48 ? 7.465 93.371 25.866 1.00 39.90 ? 48 SER A O 1 ATOM 360 C CB . SER A 1 48 ? 5.374 91.436 25.053 1.00 38.35 ? 48 SER A CB 1 ATOM 361 O OG . SER A 1 48 ? 4.048 90.966 25.170 1.00 41.12 ? 48 SER A OG 1 ATOM 362 N N . GLN A 1 49 ? 8.461 91.495 26.581 1.00 39.21 ? 49 GLN A N 1 ATOM 363 C CA . GLN A 1 49 ? 9.784 92.082 26.496 1.00 38.47 ? 49 GLN A CA 1 ATOM 364 C C . GLN A 1 49 ? 10.739 91.276 25.647 1.00 36.20 ? 49 GLN A C 1 ATOM 365 O O . GLN A 1 49 ? 10.825 90.059 25.784 1.00 36.28 ? 49 GLN A O 1 ATOM 366 C CB . GLN A 1 49 ? 10.371 92.213 27.897 1.00 42.91 ? 49 GLN A CB 1 ATOM 367 C CG . GLN A 1 49 ? 9.417 92.804 28.911 1.00 48.33 ? 49 GLN A CG 1 ATOM 368 C CD . GLN A 1 49 ? 10.028 92.870 30.292 1.00 51.64 ? 49 GLN A CD 1 ATOM 369 O OE1 . GLN A 1 49 ? 10.470 91.857 30.835 1.00 54.67 ? 49 GLN A OE1 1 ATOM 370 N NE2 . GLN A 1 49 ? 10.056 94.064 30.870 1.00 53.42 ? 49 GLN A NE2 1 ATOM 371 N N . PRO A 1 50 ? 11.474 91.948 24.751 1.00 34.37 ? 50 PRO A N 1 ATOM 372 C CA . PRO A 1 50 ? 12.424 91.222 23.910 1.00 33.43 ? 50 PRO A CA 1 ATOM 373 C C . PRO A 1 50 ? 13.541 90.708 24.807 1.00 32.77 ? 50 PRO A C 1 ATOM 374 O O . PRO A 1 50 ? 13.735 91.213 25.912 1.00 32.63 ? 50 PRO A O 1 ATOM 375 C CB . PRO A 1 50 ? 12.900 92.287 22.923 1.00 33.83 ? 50 PRO A CB 1 ATOM 376 C CG . PRO A 1 50 ? 12.800 93.561 23.725 1.00 34.28 ? 50 PRO A CG 1 ATOM 377 C CD . PRO A 1 50 ? 11.483 93.392 24.449 1.00 34.21 ? 50 PRO A CD 1 ATOM 378 N N . MET A 1 51 ? 14.272 89.709 24.336 1.00 32.79 ? 51 MET A N 1 ATOM 379 C CA . MET A 1 51 ? 15.362 89.135 25.111 1.00 33.19 ? 51 MET A CA 1 ATOM 380 C C . MET A 1 51 ? 16.604 88.931 24.263 1.00 32.43 ? 51 MET A C 1 ATOM 381 O O . MET A 1 51 ? 16.540 88.952 23.035 1.00 29.82 ? 51 MET A O 1 ATOM 382 C CB . MET A 1 51 ? 14.935 87.791 25.705 1.00 34.03 ? 51 MET A CB 1 ATOM 383 C CG . MET A 1 51 ? 13.971 87.912 26.864 1.00 39.14 ? 51 MET A CG 1 ATOM 384 S SD . MET A 1 51 ? 13.389 86.301 27.399 1.00 48.28 ? 51 MET A SD 1 ATOM 385 C CE . MET A 1 51 ? 14.865 85.670 28.256 1.00 43.56 ? 51 MET A CE 1 ATOM 386 N N . GLY A 1 52 ? 17.735 88.736 24.935 1.00 31.97 ? 52 GLY A N 1 ATOM 387 C CA . GLY A 1 52 ? 18.985 88.513 24.238 1.00 31.56 ? 52 GLY A CA 1 ATOM 388 C C . GLY A 1 52 ? 19.322 89.582 23.224 1.00 32.20 ? 52 GLY A C 1 ATOM 389 O O . GLY A 1 52 ? 19.114 90.767 23.463 1.00 34.06 ? 52 GLY A O 1 ATOM 390 N N . LEU A 1 53 ? 19.839 89.154 22.079 1.00 33.35 ? 53 LEU A N 1 ATOM 391 C CA . LEU A 1 53 ? 20.231 90.070 21.019 1.00 35.11 ? 53 LEU A CA 1 ATOM 392 C C . LEU A 1 53 ? 19.076 90.866 20.422 1.00 36.63 ? 53 LEU A C 1 ATOM 393 O O . LEU A 1 53 ? 19.293 91.890 19.773 1.00 37.86 ? 53 LEU A O 1 ATOM 394 C CB . LEU A 1 53 ? 20.956 89.291 19.925 1.00 34.42 ? 53 LEU A CB 1 ATOM 395 C CG . LEU A 1 53 ? 22.276 88.698 20.424 1.00 36.68 ? 53 LEU A CG 1 ATOM 396 C CD1 . LEU A 1 53 ? 22.883 87.788 19.373 1.00 34.34 ? 53 LEU A CD1 1 ATOM 397 C CD2 . LEU A 1 53 ? 23.227 89.840 20.775 1.00 36.17 ? 53 LEU A CD2 1 ATOM 398 N N . TRP A 1 54 ? 17.849 90.403 20.638 1.00 36.02 ? 54 TRP A N 1 ATOM 399 C CA . TRP A 1 54 ? 16.689 91.104 20.111 1.00 35.65 ? 54 TRP A CA 1 ATOM 400 C C . TRP A 1 54 ? 16.411 92.384 20.886 1.00 36.45 ? 54 TRP A C 1 ATOM 401 O O . TRP A 1 54 ? 15.580 93.193 20.481 1.00 36.03 ? 54 TRP A O 1 ATOM 402 C CB . TRP A 1 54 ? 15.466 90.183 20.120 1.00 33.62 ? 54 TRP A CB 1 ATOM 403 C CG . TRP A 1 54 ? 15.486 89.233 18.959 1.00 32.34 ? 54 TRP A CG 1 ATOM 404 C CD1 . TRP A 1 54 ? 15.113 89.503 17.674 1.00 31.44 ? 54 TRP A CD1 1 ATOM 405 C CD2 . TRP A 1 54 ? 15.977 87.888 18.961 1.00 31.61 ? 54 TRP A CD2 1 ATOM 406 N NE1 . TRP A 1 54 ? 15.343 88.413 16.875 1.00 32.49 ? 54 TRP A NE1 1 ATOM 407 C CE2 . TRP A 1 54 ? 15.873 87.406 17.640 1.00 32.59 ? 54 TRP A CE2 1 ATOM 408 C CE3 . TRP A 1 54 ? 16.499 87.044 19.953 1.00 31.60 ? 54 TRP A CE3 1 ATOM 409 C CZ2 . TRP A 1 54 ? 16.270 86.114 17.282 1.00 32.26 ? 54 TRP A CZ2 1 ATOM 410 C CZ3 . TRP A 1 54 ? 16.896 85.761 19.596 1.00 29.94 ? 54 TRP A CZ3 1 ATOM 411 C CH2 . TRP A 1 54 ? 16.777 85.309 18.273 1.00 31.77 ? 54 TRP A CH2 1 ATOM 412 N N . ARG A 1 55 ? 17.110 92.565 22.002 1.00 38.08 ? 55 ARG A N 1 ATOM 413 C CA . ARG A 1 55 ? 16.946 93.776 22.794 1.00 41.11 ? 55 ARG A CA 1 ATOM 414 C C . ARG A 1 55 ? 17.583 94.935 22.032 1.00 42.45 ? 55 ARG A C 1 ATOM 415 O O . ARG A 1 55 ? 17.272 96.095 22.277 1.00 42.41 ? 55 ARG A O 1 ATOM 416 C CB . ARG A 1 55 ? 17.617 93.622 24.160 1.00 40.64 ? 55 ARG A CB 1 ATOM 417 C CG . ARG A 1 55 ? 16.854 92.737 25.128 1.00 42.00 ? 55 ARG A CG 1 ATOM 418 C CD . ARG A 1 55 ? 17.630 92.538 26.415 1.00 40.32 ? 55 ARG A CD 1 ATOM 419 N NE . ARG A 1 55 ? 18.882 91.823 26.178 1.00 42.66 ? 55 ARG A NE 1 ATOM 420 C CZ . ARG A 1 55 ? 19.834 91.665 27.093 1.00 44.02 ? 55 ARG A CZ 1 ATOM 421 N NH1 . ARG A 1 55 ? 19.677 92.174 28.307 1.00 45.10 ? 55 ARG A NH1 1 ATOM 422 N NH2 . ARG A 1 55 ? 20.943 91.001 26.796 1.00 44.04 ? 55 ARG A NH2 1 ATOM 423 N N . GLN A 1 56 ? 18.473 94.605 21.101 1.00 45.36 ? 56 GLN A N 1 ATOM 424 C CA . GLN A 1 56 ? 19.155 95.612 20.295 1.00 49.54 ? 56 GLN A CA 1 ATOM 425 C C . GLN A 1 56 ? 18.499 95.788 18.932 1.00 49.99 ? 56 GLN A C 1 ATOM 426 O O . GLN A 1 56 ? 18.892 96.664 18.162 1.00 51.55 ? 56 GLN A O 1 ATOM 427 C CB . GLN A 1 56 ? 20.621 95.228 20.081 1.00 52.31 ? 56 GLN A CB 1 ATOM 428 C CG . GLN A 1 56 ? 21.492 95.264 21.325 1.00 57.43 ? 56 GLN A CG 1 ATOM 429 C CD . GLN A 1 56 ? 22.920 94.825 21.033 1.00 61.33 ? 56 GLN A CD 1 ATOM 430 O OE1 . GLN A 1 56 ? 23.172 93.662 20.704 1.00 62.30 ? 56 GLN A OE1 1 ATOM 431 N NE2 . GLN A 1 56 ? 23.862 95.760 21.139 1.00 62.89 ? 56 GLN A NE2 1 ATOM 432 N N . VAL A 1 57 ? 17.507 94.958 18.630 1.00 49.21 ? 57 VAL A N 1 ATOM 433 C CA . VAL A 1 57 ? 16.825 95.035 17.343 1.00 48.56 ? 57 VAL A CA 1 ATOM 434 C C . VAL A 1 57 ? 15.665 96.020 17.376 1.00 49.82 ? 57 VAL A C 1 ATOM 435 O O . VAL A 1 57 ? 14.837 95.992 18.284 1.00 50.23 ? 57 VAL A O 1 ATOM 436 C CB . VAL A 1 57 ? 16.305 93.653 16.915 1.00 48.82 ? 57 VAL A CB 1 ATOM 437 C CG1 . VAL A 1 57 ? 15.584 93.755 15.582 1.00 46.84 ? 57 VAL A CG1 1 ATOM 438 C CG2 . VAL A 1 57 ? 17.469 92.674 16.822 1.00 47.51 ? 57 VAL A CG2 1 ATOM 439 N N . GLU A 1 58 ? 15.605 96.892 16.376 1.00 50.48 ? 58 GLU A N 1 ATOM 440 C CA . GLU A 1 58 ? 14.547 97.888 16.318 1.00 50.50 ? 58 GLU A CA 1 ATOM 441 C C . GLU A 1 58 ? 13.605 97.688 15.140 1.00 48.08 ? 58 GLU A C 1 ATOM 442 O O . GLU A 1 58 ? 14.033 97.336 14.045 1.00 47.06 ? 58 GLU A O 1 ATOM 443 C CB . GLU A 1 58 ? 15.161 99.291 16.259 1.00 54.89 ? 58 GLU A CB 1 ATOM 444 C CG . GLU A 1 58 ? 15.939 99.674 17.515 1.00 60.64 ? 58 GLU A CG 1 ATOM 445 C CD . GLU A 1 58 ? 16.555 101.062 17.433 1.00 65.06 ? 58 GLU A CD 1 ATOM 446 O OE1 . GLU A 1 58 ? 15.801 102.046 17.251 1.00 66.87 ? 58 GLU A OE1 1 ATOM 447 O OE2 . GLU A 1 58 ? 17.796 101.169 17.556 1.00 67.02 ? 58 GLU A OE2 1 ATOM 448 N N . GLY A 1 59 ? 12.316 97.899 15.380 1.00 46.97 ? 59 GLY A N 1 ATOM 449 C CA . GLY A 1 59 ? 11.332 97.768 14.320 1.00 47.60 ? 59 GLY A CA 1 ATOM 450 C C . GLY A 1 59 ? 10.844 96.378 13.955 1.00 47.28 ? 59 GLY A C 1 ATOM 451 O O . GLY A 1 59 ? 10.019 96.235 13.053 1.00 47.30 ? 59 GLY A O 1 ATOM 452 N N . MET A 1 60 ? 11.334 95.345 14.631 1.00 46.36 ? 60 MET A N 1 ATOM 453 C CA . MET A 1 60 ? 10.881 93.996 14.312 1.00 45.14 ? 60 MET A CA 1 ATOM 454 C C . MET A 1 60 ? 9.497 93.752 14.891 1.00 44.14 ? 60 MET A C 1 ATOM 455 O O . MET A 1 60 ? 8.659 93.100 14.276 1.00 44.43 ? 60 MET A O 1 ATOM 456 C CB . MET A 1 60 ? 11.842 92.950 14.867 1.00 45.84 ? 60 MET A CB 1 ATOM 457 C CG . MET A 1 60 ? 11.398 91.523 14.587 1.00 44.34 ? 60 MET A CG 1 ATOM 458 S SD . MET A 1 60 ? 12.359 90.319 15.506 1.00 42.82 ? 60 MET A SD 1 ATOM 459 C CE . MET A 1 60 ? 13.552 89.916 14.337 1.00 46.30 ? 60 MET A CE 1 ATOM 460 N N . GLU A 1 61 ? 9.258 94.287 16.079 1.00 44.76 ? 61 GLU A N 1 ATOM 461 C CA . GLU A 1 61 ? 7.974 94.105 16.732 1.00 44.87 ? 61 GLU A CA 1 ATOM 462 C C . GLU A 1 61 ? 7.665 95.288 17.628 1.00 46.30 ? 61 GLU A C 1 ATOM 463 O O . GLU A 1 61 ? 8.572 95.914 18.169 1.00 49.26 ? 61 GLU A O 1 ATOM 464 C CB . GLU A 1 61 ? 7.998 92.823 17.570 1.00 44.73 ? 61 GLU A CB 1 ATOM 465 C CG . GLU A 1 61 ? 6.653 92.444 18.152 1.00 44.57 ? 61 GLU A CG 1 ATOM 466 C CD . GLU A 1 61 ? 5.625 92.182 17.076 1.00 44.97 ? 61 GLU A CD 1 ATOM 467 O OE1 . GLU A 1 61 ? 5.790 91.206 16.318 1.00 45.89 ? 61 GLU A OE1 1 ATOM 468 O OE2 . GLU A 1 61 ? 4.656 92.960 16.980 1.00 49.28 ? 61 GLU A OE2 1 ATOM 469 N N . ASP A 1 62 ? 6.382 95.598 17.774 1.00 46.48 ? 62 ASP A N 1 ATOM 470 C CA . ASP A 1 62 ? 5.952 96.690 18.639 1.00 46.76 ? 62 ASP A CA 1 ATOM 471 C C . ASP A 1 62 ? 5.567 96.037 19.963 1.00 46.08 ? 62 ASP A C 1 ATOM 472 O O . ASP A 1 62 ? 4.419 95.629 20.161 1.00 46.01 ? 62 ASP A O 1 ATOM 473 C CB . ASP A 1 62 ? 4.737 97.396 18.042 1.00 48.35 ? 62 ASP A CB 1 ATOM 474 C CG . ASP A 1 62 ? 4.265 98.555 18.893 1.00 49.08 ? 62 ASP A CG 1 ATOM 475 O OD1 . ASP A 1 62 ? 4.260 98.425 20.135 1.00 50.25 ? 62 ASP A OD1 1 ATOM 476 O OD2 . ASP A 1 62 ? 3.885 99.594 18.318 1.00 52.48 ? 62 ASP A OD2 1 ATOM 477 N N . TRP A 1 63 ? 6.531 95.943 20.871 1.00 44.42 ? 63 TRP A N 1 ATOM 478 C CA . TRP A 1 63 ? 6.303 95.298 22.154 1.00 43.07 ? 63 TRP A CA 1 ATOM 479 C C . TRP A 1 63 ? 5.164 95.852 23.001 1.00 44.03 ? 63 TRP A C 1 ATOM 480 O O . TRP A 1 63 ? 4.537 95.107 23.757 1.00 42.67 ? 63 TRP A O 1 ATOM 481 C CB . TRP A 1 63 ? 7.611 95.275 22.945 1.00 40.59 ? 63 TRP A CB 1 ATOM 482 C CG . TRP A 1 63 ? 8.683 94.542 22.197 1.00 38.24 ? 63 TRP A CG 1 ATOM 483 C CD1 . TRP A 1 63 ? 9.837 95.065 21.695 1.00 38.23 ? 63 TRP A CD1 1 ATOM 484 C CD2 . TRP A 1 63 ? 8.663 93.163 21.801 1.00 38.02 ? 63 TRP A CD2 1 ATOM 485 N NE1 . TRP A 1 63 ? 10.536 94.102 21.005 1.00 38.68 ? 63 TRP A NE1 1 ATOM 486 C CE2 . TRP A 1 63 ? 9.838 92.925 21.055 1.00 37.57 ? 63 TRP A CE2 1 ATOM 487 C CE3 . TRP A 1 63 ? 7.765 92.106 22.001 1.00 38.05 ? 63 TRP A CE3 1 ATOM 488 C CZ2 . TRP A 1 63 ? 10.138 91.672 20.507 1.00 38.69 ? 63 TRP A CZ2 1 ATOM 489 C CZ3 . TRP A 1 63 ? 8.063 90.858 21.456 1.00 38.11 ? 63 TRP A CZ3 1 ATOM 490 C CH2 . TRP A 1 63 ? 9.241 90.653 20.718 1.00 38.40 ? 63 TRP A CH2 1 ATOM 491 N N . LYS A 1 64 ? 4.877 97.143 22.882 1.00 45.60 ? 64 LYS A N 1 ATOM 492 C CA . LYS A 1 64 ? 3.787 97.712 23.666 1.00 47.65 ? 64 LYS A CA 1 ATOM 493 C C . LYS A 1 64 ? 2.462 97.125 23.193 1.00 46.80 ? 64 LYS A C 1 ATOM 494 O O . LYS A 1 64 ? 1.565 96.851 23.993 1.00 46.16 ? 64 LYS A O 1 ATOM 495 C CB . LYS A 1 64 ? 3.761 99.239 23.538 1.00 50.73 ? 64 LYS A CB 1 ATOM 496 C CG . LYS A 1 64 ? 4.893 99.930 24.286 1.00 55.60 ? 64 LYS A CG 1 ATOM 497 C CD . LYS A 1 64 ? 4.768 101.445 24.233 1.00 58.72 ? 64 LYS A CD 1 ATOM 498 C CE . LYS A 1 64 ? 5.840 102.120 25.082 1.00 60.89 ? 64 LYS A CE 1 ATOM 499 N NZ . LYS A 1 64 ? 7.220 101.792 24.620 1.00 63.40 ? 64 LYS A NZ 1 ATOM 500 N N . GLN A 1 65 ? 2.341 96.922 21.889 1.00 45.92 ? 65 GLN A N 1 ATOM 501 C CA . GLN A 1 65 ? 1.113 96.360 21.355 1.00 46.09 ? 65 GLN A CA 1 ATOM 502 C C . GLN A 1 65 ? 1.092 94.852 21.586 1.00 44.19 ? 65 GLN A C 1 ATOM 503 O O . GLN A 1 65 ? 0.029 94.265 21.790 1.00 43.81 ? 65 GLN A O 1 ATOM 504 C CB . GLN A 1 65 ? 0.978 96.675 19.864 1.00 47.93 ? 65 GLN A CB 1 ATOM 505 C CG . GLN A 1 65 ? -0.443 96.537 19.336 1.00 51.48 ? 65 GLN A CG 1 ATOM 506 C CD . GLN A 1 65 ? -1.455 97.314 20.173 1.00 55.63 ? 65 GLN A CD 1 ATOM 507 O OE1 . GLN A 1 65 ? -1.162 98.410 20.669 1.00 57.28 ? 65 GLN A OE1 1 ATOM 508 N NE2 . GLN A 1 65 ? -2.657 96.757 20.322 1.00 53.70 ? 65 GLN A NE2 1 ATOM 509 N N . ASP A 1 66 ? 2.260 94.217 21.563 1.00 41.55 ? 66 ASP A N 1 ATOM 510 C CA . ASP A 1 66 ? 2.282 92.782 21.800 1.00 39.57 ? 66 ASP A CA 1 ATOM 511 C C . ASP A 1 66 ? 1.867 92.518 23.241 1.00 38.49 ? 66 ASP A C 1 ATOM 512 O O . ASP A 1 66 ? 1.270 91.479 23.542 1.00 36.52 ? 66 ASP A O 1 ATOM 513 C CB . ASP A 1 66 ? 3.661 92.187 21.549 1.00 40.13 ? 66 ASP A CB 1 ATOM 514 C CG . ASP A 1 66 ? 3.614 90.679 21.438 1.00 41.96 ? 66 ASP A CG 1 ATOM 515 O OD1 . ASP A 1 66 ? 2.977 90.185 20.482 1.00 43.03 ? 66 ASP A OD1 1 ATOM 516 O OD2 . ASP A 1 66 ? 4.188 89.988 22.305 1.00 40.64 ? 66 ASP A OD2 1 ATOM 517 N N . SER A 1 67 ? 2.172 93.464 24.127 1.00 34.86 ? 67 SER A N 1 ATOM 518 C CA . SER A 1 67 ? 1.805 93.330 25.531 1.00 34.85 ? 67 SER A CA 1 ATOM 519 C C . SER A 1 67 ? 0.294 93.209 25.638 1.00 35.07 ? 67 SER A C 1 ATOM 520 O O . SER A 1 67 ? -0.227 92.441 26.448 1.00 34.17 ? 67 SER A O 1 ATOM 521 C CB . SER A 1 67 ? 2.265 94.550 26.338 1.00 34.24 ? 67 SER A CB 1 ATOM 522 O OG . SER A 1 67 ? 3.676 94.658 26.364 1.00 34.69 ? 67 SER A OG 1 ATOM 523 N N . GLN A 1 68 ? -0.410 93.979 24.814 1.00 36.27 ? 68 GLN A N 1 ATOM 524 C CA . GLN A 1 68 ? -1.865 93.955 24.820 1.00 35.45 ? 68 GLN A CA 1 ATOM 525 C C . GLN A 1 68 ? -2.382 92.617 24.302 1.00 34.03 ? 68 GLN A C 1 ATOM 526 O O . GLN A 1 68 ? -3.349 92.073 24.825 1.00 35.13 ? 68 GLN A O 1 ATOM 527 C CB . GLN A 1 68 ? -2.415 95.110 23.972 1.00 39.25 ? 68 GLN A CB 1 ATOM 528 C CG . GLN A 1 68 ? -2.130 96.490 24.557 1.00 40.75 ? 68 GLN A CG 1 ATOM 529 C CD . GLN A 1 68 ? -2.652 96.634 25.978 1.00 42.23 ? 68 GLN A CD 1 ATOM 530 O OE1 . GLN A 1 68 ? -3.845 96.462 26.234 1.00 44.44 ? 68 GLN A OE1 1 ATOM 531 N NE2 . GLN A 1 68 ? -1.759 96.948 26.908 1.00 41.39 ? 68 GLN A NE2 1 ATOM 532 N N . LEU A 1 69 ? -1.738 92.086 23.271 1.00 33.26 ? 69 LEU A N 1 ATOM 533 C CA . LEU A 1 69 ? -2.145 90.799 22.724 1.00 34.45 ? 69 LEU A CA 1 ATOM 534 C C . LEU A 1 69 ? -1.951 89.696 23.785 1.00 34.67 ? 69 LEU A C 1 ATOM 535 O O . LEU A 1 69 ? -2.868 88.919 24.061 1.00 33.67 ? 69 LEU A O 1 ATOM 536 C CB . LEU A 1 69 ? -1.325 90.486 21.470 1.00 34.37 ? 69 LEU A CB 1 ATOM 537 C CG . LEU A 1 69 ? -1.516 89.120 20.797 1.00 36.32 ? 69 LEU A CG 1 ATOM 538 C CD1 . LEU A 1 69 ? -2.978 88.907 20.405 1.00 36.28 ? 69 LEU A CD1 1 ATOM 539 C CD2 . LEU A 1 69 ? -0.613 89.049 19.573 1.00 35.89 ? 69 LEU A CD2 1 ATOM 540 N N . GLN A 1 70 ? -0.764 89.645 24.386 1.00 34.36 ? 70 GLN A N 1 ATOM 541 C CA . GLN A 1 70 ? -0.471 88.642 25.412 1.00 34.95 ? 70 GLN A CA 1 ATOM 542 C C . GLN A 1 70 ? -1.464 88.693 26.572 1.00 34.78 ? 70 GLN A C 1 ATOM 543 O O . GLN A 1 70 ? -1.790 87.660 27.152 1.00 35.19 ? 70 GLN A O 1 ATOM 544 C CB . GLN A 1 70 ? 0.955 88.811 25.952 1.00 33.47 ? 70 GLN A CB 1 ATOM 545 C CG . GLN A 1 70 ? 2.060 88.609 24.916 1.00 34.33 ? 70 GLN A CG 1 ATOM 546 C CD . GLN A 1 70 ? 1.894 87.334 24.096 1.00 34.18 ? 70 GLN A CD 1 ATOM 547 O OE1 . GLN A 1 70 ? 1.467 86.299 24.607 1.00 32.99 ? 70 GLN A OE1 1 ATOM 548 N NE2 . GLN A 1 70 ? 2.244 87.407 22.819 1.00 34.48 ? 70 GLN A NE2 1 ATOM 549 N N . LYS A 1 71 ? -1.941 89.888 26.916 1.00 35.66 ? 71 LYS A N 1 ATOM 550 C CA . LYS A 1 71 ? -2.912 90.022 28.002 1.00 34.73 ? 71 LYS A CA 1 ATOM 551 C C . LYS A 1 71 ? -4.201 89.334 27.583 1.00 34.89 ? 71 LYS A C 1 ATOM 552 O O . LYS A 1 71 ? -4.871 88.691 28.394 1.00 36.22 ? 71 LYS A O 1 ATOM 553 C CB . LYS A 1 71 ? -3.213 91.493 28.301 1.00 37.99 ? 71 LYS A CB 1 ATOM 554 C CG . LYS A 1 71 ? -2.050 92.290 28.880 1.00 41.31 ? 71 LYS A CG 1 ATOM 555 C CD . LYS A 1 71 ? -2.456 93.739 29.147 1.00 43.82 ? 71 LYS A CD 1 ATOM 556 C CE . LYS A 1 71 ? -1.277 94.570 29.632 1.00 46.18 ? 71 LYS A CE 1 ATOM 557 N NZ . LYS A 1 71 ? -1.631 96.018 29.745 1.00 48.79 ? 71 LYS A NZ 1 ATOM 558 N N . ALA A 1 72 ? -4.552 89.485 26.309 1.00 33.36 ? 72 ALA A N 1 ATOM 559 C CA . ALA A 1 72 ? -5.757 88.869 25.776 1.00 33.51 ? 72 ALA A CA 1 ATOM 560 C C . ALA A 1 72 ? -5.543 87.356 25.732 1.00 32.46 ? 72 ALA A C 1 ATOM 561 O O . ALA A 1 72 ? -6.429 86.587 26.086 1.00 31.27 ? 72 ALA A O 1 ATOM 562 C CB . ALA A 1 72 ? -6.046 89.409 24.371 1.00 33.49 ? 72 ALA A CB 1 ATOM 563 N N . ARG A 1 73 ? -4.360 86.936 25.295 1.00 31.86 ? 73 ARG A N 1 ATOM 564 C CA . ARG A 1 73 ? -4.043 85.512 25.234 1.00 32.19 ? 73 ARG A CA 1 ATOM 565 C C . ARG A 1 73 ? -4.117 84.939 26.652 1.00 31.61 ? 73 ARG A C 1 ATOM 566 O O . ARG A 1 73 ? -4.731 83.898 26.886 1.00 31.37 ? 73 ARG A O 1 ATOM 567 C CB . ARG A 1 73 ? -2.637 85.307 24.668 1.00 32.17 ? 73 ARG A CB 1 ATOM 568 C CG . ARG A 1 73 ? -2.464 85.703 23.198 1.00 34.27 ? 73 ARG A CG 1 ATOM 569 C CD . ARG A 1 73 ? -3.114 84.696 22.272 1.00 34.79 ? 73 ARG A CD 1 ATOM 570 N NE . ARG A 1 73 ? -2.932 85.039 20.862 1.00 36.88 ? 73 ARG A NE 1 ATOM 571 C CZ . ARG A 1 73 ? -1.779 84.958 20.206 1.00 36.26 ? 73 ARG A CZ 1 ATOM 572 N NH1 . ARG A 1 73 ? -0.686 84.545 20.825 1.00 36.41 ? 73 ARG A NH1 1 ATOM 573 N NH2 . ARG A 1 73 ? -1.723 85.283 18.922 1.00 36.74 ? 73 ARG A NH2 1 ATOM 574 N N . GLU A 1 74 ? -3.491 85.641 27.593 1.00 31.27 ? 74 GLU A N 1 ATOM 575 C CA . GLU A 1 74 ? -3.473 85.237 28.989 1.00 31.38 ? 74 GLU A CA 1 ATOM 576 C C . GLU A 1 74 ? -4.882 84.988 29.515 1.00 32.20 ? 74 GLU A C 1 ATOM 577 O O . GLU A 1 74 ? -5.159 83.940 30.101 1.00 31.11 ? 74 GLU A O 1 ATOM 578 C CB . GLU A 1 74 ? -2.805 86.325 29.837 1.00 33.20 ? 74 GLU A CB 1 ATOM 579 C CG . GLU A 1 74 ? -2.740 85.996 31.326 1.00 34.74 ? 74 GLU A CG 1 ATOM 580 C CD . GLU A 1 74 ? -2.381 87.200 32.180 1.00 35.48 ? 74 GLU A CD 1 ATOM 581 O OE1 . GLU A 1 74 ? -1.479 87.967 31.785 1.00 35.37 ? 74 GLU A OE1 1 ATOM 582 O OE2 . GLU A 1 74 ? -2.993 87.371 33.252 1.00 35.27 ? 74 GLU A OE2 1 ATOM 583 N N . ASP A 1 75 ? -5.771 85.961 29.313 1.00 33.27 ? 75 ASP A N 1 ATOM 584 C CA . ASP A 1 75 ? -7.149 85.839 29.784 1.00 33.91 ? 75 ASP A CA 1 ATOM 585 C C . ASP A 1 75 ? -7.858 84.589 29.281 1.00 32.57 ? 75 ASP A C 1 ATOM 586 O O . ASP A 1 75 ? -8.527 83.903 30.047 1.00 32.59 ? 75 ASP A O 1 ATOM 587 C CB . ASP A 1 75 ? -7.971 87.074 29.397 1.00 39.41 ? 75 ASP A CB 1 ATOM 588 C CG . ASP A 1 75 ? -7.622 88.295 30.239 1.00 44.06 ? 75 ASP A CG 1 ATOM 589 O OD1 . ASP A 1 75 ? -7.341 88.123 31.446 1.00 47.49 ? 75 ASP A OD1 1 ATOM 590 O OD2 . ASP A 1 75 ? -7.644 89.423 29.704 1.00 47.14 ? 75 ASP A OD2 1 ATOM 591 N N . ILE A 1 76 ? -7.731 84.296 27.993 1.00 30.98 ? 76 ILE A N 1 ATOM 592 C CA . ILE A 1 76 ? -8.379 83.111 27.442 1.00 31.72 ? 76 ILE A CA 1 ATOM 593 C C . ILE A 1 76 ? -7.701 81.832 27.943 1.00 29.83 ? 76 ILE A C 1 ATOM 594 O O . ILE A 1 76 ? -8.367 80.856 28.275 1.00 31.79 ? 76 ILE A O 1 ATOM 595 C CB . ILE A 1 76 ? -8.356 83.139 25.903 1.00 33.61 ? 76 ILE A CB 1 ATOM 596 C CG1 . ILE A 1 76 ? -9.219 84.298 25.399 1.00 36.54 ? 76 ILE A CG1 1 ATOM 597 C CG2 . ILE A 1 76 ? -8.876 81.829 25.345 1.00 34.27 ? 76 ILE A CG2 1 ATOM 598 C CD1 . ILE A 1 76 ? -9.121 84.510 23.911 1.00 41.23 ? 76 ILE A CD1 1 ATOM 599 N N . PHE A 1 77 ? -6.377 81.847 28.006 1.00 28.88 ? 77 PHE A N 1 ATOM 600 C CA . PHE A 1 77 ? -5.625 80.682 28.473 1.00 29.38 ? 77 PHE A CA 1 ATOM 601 C C . PHE A 1 77 ? -6.028 80.300 29.899 1.00 29.22 ? 77 PHE A C 1 ATOM 602 O O . PHE A 1 77 ? -6.320 79.140 30.182 1.00 27.76 ? 77 PHE A O 1 ATOM 603 C CB . PHE A 1 77 ? -4.121 80.975 28.442 1.00 26.84 ? 77 PHE A CB 1 ATOM 604 C CG . PHE A 1 77 ? -3.258 79.756 28.632 1.00 25.03 ? 77 PHE A CG 1 ATOM 605 C CD1 . PHE A 1 77 ? -2.949 78.930 27.554 1.00 22.10 ? 77 PHE A CD1 1 ATOM 606 C CD2 . PHE A 1 77 ? -2.745 79.441 29.887 1.00 22.59 ? 77 PHE A CD2 1 ATOM 607 C CE1 . PHE A 1 77 ? -2.135 77.810 27.722 1.00 24.52 ? 77 PHE A CE1 1 ATOM 608 C CE2 . PHE A 1 77 ? -1.929 78.319 30.069 1.00 25.64 ? 77 PHE A CE2 1 ATOM 609 C CZ . PHE A 1 77 ? -1.621 77.503 28.987 1.00 22.50 ? 77 PHE A CZ 1 ATOM 610 N N . MET A 1 78 ? -6.043 81.277 30.801 1.00 29.74 ? 78 MET A N 1 ATOM 611 C CA . MET A 1 78 ? -6.389 80.991 32.194 1.00 29.30 ? 78 MET A CA 1 ATOM 612 C C . MET A 1 78 ? -7.847 80.585 32.368 1.00 29.74 ? 78 MET A C 1 ATOM 613 O O . MET A 1 78 ? -8.174 79.793 33.249 1.00 30.81 ? 78 MET A O 1 ATOM 614 C CB . MET A 1 78 ? -6.061 82.197 33.084 1.00 30.20 ? 78 MET A CB 1 ATOM 615 C CG . MET A 1 78 ? -4.586 82.598 33.064 1.00 27.53 ? 78 MET A CG 1 ATOM 616 S SD . MET A 1 78 ? -3.460 81.243 33.522 1.00 30.18 ? 78 MET A SD 1 ATOM 617 C CE . MET A 1 78 ? -3.854 81.068 35.255 1.00 28.18 ? 78 MET A CE 1 ATOM 618 N N . GLU A 1 79 ? -8.729 81.122 31.531 1.00 30.53 ? 79 GLU A N 1 ATOM 619 C CA . GLU A 1 79 ? -10.136 80.765 31.622 1.00 31.22 ? 79 GLU A CA 1 ATOM 620 C C . GLU A 1 79 ? -10.265 79.298 31.227 1.00 29.91 ? 79 GLU A C 1 ATOM 621 O O . GLU A 1 79 ? -11.068 78.560 31.790 1.00 32.13 ? 79 GLU A O 1 ATOM 622 C CB . GLU A 1 79 ? -10.978 81.624 30.678 1.00 35.51 ? 79 GLU A CB 1 ATOM 623 C CG . GLU A 1 79 ? -12.457 81.639 31.038 1.00 41.95 ? 79 GLU A CG 1 ATOM 624 C CD . GLU A 1 79 ? -13.328 82.211 29.930 1.00 45.73 ? 79 GLU A CD 1 ATOM 625 O OE1 . GLU A 1 79 ? -12.888 83.168 29.254 1.00 46.95 ? 79 GLU A OE1 1 ATOM 626 O OE2 . GLU A 1 79 ? -14.455 81.704 29.744 1.00 47.95 ? 79 GLU A OE2 1 ATOM 627 N N . THR A 1 80 ? -9.474 78.881 30.245 1.00 29.08 ? 80 THR A N 1 ATOM 628 C CA . THR A 1 80 ? -9.489 77.490 29.809 1.00 27.46 ? 80 THR A CA 1 ATOM 629 C C . THR A 1 80 ? -9.075 76.606 30.990 1.00 27.12 ? 80 THR A C 1 ATOM 630 O O . THR A 1 80 ? -9.711 75.591 31.275 1.00 27.17 ? 80 THR A O 1 ATOM 631 C CB . THR A 1 80 ? -8.513 77.279 28.648 1.00 27.95 ? 80 THR A CB 1 ATOM 632 O OG1 . THR A 1 80 ? -8.878 78.147 27.568 1.00 31.73 ? 80 THR A OG1 1 ATOM 633 C CG2 . THR A 1 80 ? -8.548 75.826 28.169 1.00 26.95 ? 80 THR A CG2 1 ATOM 634 N N . LEU A 1 81 ? -8.012 77.004 31.680 1.00 26.30 ? 81 LEU A N 1 ATOM 635 C CA . LEU A 1 81 ? -7.524 76.254 32.838 1.00 26.05 ? 81 LEU A CA 1 ATOM 636 C C . LEU A 1 81 ? -8.599 76.239 33.919 1.00 28.00 ? 81 LEU A C 1 ATOM 637 O O . LEU A 1 81 ? -8.866 75.205 34.542 1.00 26.77 ? 81 LEU A O 1 ATOM 638 C CB . LEU A 1 81 ? -6.260 76.911 33.399 1.00 23.82 ? 81 LEU A CB 1 ATOM 639 C CG . LEU A 1 81 ? -5.725 76.356 34.728 1.00 23.62 ? 81 LEU A CG 1 ATOM 640 C CD1 . LEU A 1 81 ? -5.535 74.850 34.648 1.00 18.23 ? 81 LEU A CD1 1 ATOM 641 C CD2 . LEU A 1 81 ? -4.412 77.037 35.050 1.00 24.33 ? 81 LEU A CD2 1 ATOM 642 N N . LYS A 1 82 ? -9.212 77.400 34.136 1.00 28.59 ? 82 LYS A N 1 ATOM 643 C CA . LYS A 1 82 ? -10.259 77.528 35.141 1.00 31.24 ? 82 LYS A CA 1 ATOM 644 C C . LYS A 1 82 ? -11.403 76.557 34.855 1.00 30.86 ? 82 LYS A C 1 ATOM 645 O O . LYS A 1 82 ? -11.896 75.894 35.769 1.00 30.83 ? 82 LYS A O 1 ATOM 646 C CB . LYS A 1 82 ? -10.784 78.966 35.179 1.00 34.99 ? 82 LYS A CB 1 ATOM 647 C CG . LYS A 1 82 ? -11.585 79.294 36.433 1.00 41.04 ? 82 LYS A CG 1 ATOM 648 C CD . LYS A 1 82 ? -12.248 80.665 36.352 1.00 45.96 ? 82 LYS A CD 1 ATOM 649 C CE . LYS A 1 82 ? -13.486 80.652 35.451 1.00 49.37 ? 82 LYS A CE 1 ATOM 650 N NZ . LYS A 1 82 ? -13.167 80.400 34.017 1.00 51.99 ? 82 LYS A NZ 1 ATOM 651 N N . ASP A 1 83 ? -11.814 76.458 33.589 1.00 30.09 ? 83 ASP A N 1 ATOM 652 C CA . ASP A 1 83 ? -12.896 75.546 33.213 1.00 31.23 ? 83 ASP A CA 1 ATOM 653 C C . ASP A 1 83 ? -12.529 74.079 33.440 1.00 30.57 ? 83 ASP A C 1 ATOM 654 O O . ASP A 1 83 ? -13.365 73.275 33.850 1.00 31.08 ? 83 ASP A O 1 ATOM 655 C CB . ASP A 1 83 ? -13.294 75.742 31.748 1.00 34.24 ? 83 ASP A CB 1 ATOM 656 C CG . ASP A 1 83 ? -13.907 77.104 31.485 1.00 39.87 ? 83 ASP A CG 1 ATOM 657 O OD1 . ASP A 1 83 ? -14.554 77.655 32.400 1.00 43.02 ? 83 ASP A OD1 1 ATOM 658 O OD2 . ASP A 1 83 ? -13.760 77.620 30.357 1.00 42.80 ? 83 ASP A OD2 1 ATOM 659 N N . ILE A 1 84 ? -11.280 73.721 33.165 1.00 29.27 ? 84 ILE A N 1 ATOM 660 C CA . ILE A 1 84 ? -10.851 72.345 33.372 1.00 26.77 ? 84 ILE A CA 1 ATOM 661 C C . ILE A 1 84 ? -10.937 72.020 34.860 1.00 28.37 ? 84 ILE A C 1 ATOM 662 O O . ILE A 1 84 ? -11.518 71.004 35.256 1.00 27.08 ? 84 ILE A O 1 ATOM 663 C CB . ILE A 1 84 ? -9.404 72.123 32.912 1.00 25.01 ? 84 ILE A CB 1 ATOM 664 C CG1 . ILE A 1 84 ? -9.268 72.429 31.415 1.00 24.51 ? 84 ILE A CG1 1 ATOM 665 C CG2 . ILE A 1 84 ? -8.990 70.682 33.203 1.00 25.11 ? 84 ILE A CG2 1 ATOM 666 C CD1 . ILE A 1 84 ? -7.820 72.486 30.936 1.00 22.37 ? 84 ILE A CD1 1 ATOM 667 N N . VAL A 1 85 ? -10.357 72.881 35.688 1.00 30.16 ? 85 VAL A N 1 ATOM 668 C CA . VAL A 1 85 ? -10.389 72.653 37.128 1.00 34.26 ? 85 VAL A CA 1 ATOM 669 C C . VAL A 1 85 ? -11.831 72.562 37.630 1.00 35.11 ? 85 VAL A C 1 ATOM 670 O O . VAL A 1 85 ? -12.138 71.740 38.485 1.00 36.55 ? 85 VAL A O 1 ATOM 671 C CB . VAL A 1 85 ? -9.626 73.763 37.891 1.00 34.58 ? 85 VAL A CB 1 ATOM 672 C CG1 . VAL A 1 85 ? -9.866 73.629 39.393 1.00 35.84 ? 85 VAL A CG1 1 ATOM 673 C CG2 . VAL A 1 85 ? -8.128 73.646 37.602 1.00 34.47 ? 85 VAL A CG2 1 ATOM 674 N N . GLU A 1 86 ? -12.712 73.394 37.083 1.00 37.76 ? 86 GLU A N 1 ATOM 675 C CA . GLU A 1 86 ? -14.122 73.382 37.471 1.00 39.64 ? 86 GLU A CA 1 ATOM 676 C C . GLU A 1 86 ? -14.741 72.027 37.134 1.00 39.21 ? 86 GLU A C 1 ATOM 677 O O . GLU A 1 86 ? -15.466 71.439 37.942 1.00 38.66 ? 86 GLU A O 1 ATOM 678 C CB . GLU A 1 86 ? -14.894 74.478 36.727 1.00 43.44 ? 86 GLU A CB 1 ATOM 679 C CG . GLU A 1 86 ? -15.496 75.550 37.617 1.00 51.65 ? 86 GLU A CG 1 ATOM 680 C CD . GLU A 1 86 ? -14.474 76.572 38.086 1.00 56.24 ? 86 GLU A CD 1 ATOM 681 O OE1 . GLU A 1 86 ? -13.386 76.156 38.549 1.00 59.87 ? 86 GLU A OE1 1 ATOM 682 O OE2 . GLU A 1 86 ? -14.762 77.789 37.998 1.00 56.70 ? 86 GLU A OE2 1 ATOM 683 N N . TYR A 1 87 ? -14.456 71.537 35.930 1.00 37.05 ? 87 TYR A N 1 ATOM 684 C CA . TYR A 1 87 ? -14.989 70.256 35.483 1.00 34.71 ? 87 TYR A CA 1 ATOM 685 C C . TYR A 1 87 ? -14.612 69.116 36.427 1.00 34.32 ? 87 TYR A C 1 ATOM 686 O O . TYR A 1 87 ? -15.416 68.220 36.670 1.00 34.62 ? 87 TYR A O 1 ATOM 687 C CB . TYR A 1 87 ? -14.489 69.924 34.070 1.00 32.83 ? 87 TYR A CB 1 ATOM 688 C CG . TYR A 1 87 ? -14.936 68.560 33.594 1.00 31.38 ? 87 TYR A CG 1 ATOM 689 C CD1 . TYR A 1 87 ? -16.190 68.378 33.017 1.00 32.25 ? 87 TYR A CD1 1 ATOM 690 C CD2 . TYR A 1 87 ? -14.128 67.441 33.777 1.00 28.94 ? 87 TYR A CD2 1 ATOM 691 C CE1 . TYR A 1 87 ? -16.630 67.107 32.633 1.00 32.47 ? 87 TYR A CE1 1 ATOM 692 C CE2 . TYR A 1 87 ? -14.557 66.172 33.401 1.00 31.70 ? 87 TYR A CE2 1 ATOM 693 C CZ . TYR A 1 87 ? -15.809 66.012 32.830 1.00 31.49 ? 87 TYR A CZ 1 ATOM 694 O OH . TYR A 1 87 ? -16.236 64.757 32.462 1.00 33.48 ? 87 TYR A OH 1 ATOM 695 N N . TYR A 1 88 ? -13.392 69.134 36.951 1.00 34.89 ? 88 TYR A N 1 ATOM 696 C CA . TYR A 1 88 ? -12.966 68.076 37.862 1.00 36.77 ? 88 TYR A CA 1 ATOM 697 C C . TYR A 1 88 ? -13.290 68.386 39.322 1.00 39.55 ? 88 TYR A C 1 ATOM 698 O O . TYR A 1 88 ? -12.982 67.597 40.213 1.00 38.66 ? 88 TYR A O 1 ATOM 699 C CB . TYR A 1 88 ? -11.467 67.792 37.702 1.00 34.83 ? 88 TYR A CB 1 ATOM 700 C CG . TYR A 1 88 ? -11.149 67.044 36.426 1.00 35.35 ? 88 TYR A CG 1 ATOM 701 C CD1 . TYR A 1 88 ? -10.546 67.686 35.345 1.00 32.40 ? 88 TYR A CD1 1 ATOM 702 C CD2 . TYR A 1 88 ? -11.522 65.710 36.275 1.00 34.04 ? 88 TYR A CD2 1 ATOM 703 C CE1 . TYR A 1 88 ? -10.327 67.015 34.139 1.00 35.44 ? 88 TYR A CE1 1 ATOM 704 C CE2 . TYR A 1 88 ? -11.313 65.032 35.078 1.00 35.47 ? 88 TYR A CE2 1 ATOM 705 C CZ . TYR A 1 88 ? -10.717 65.688 34.013 1.00 35.03 ? 88 TYR A CZ 1 ATOM 706 O OH . TYR A 1 88 ? -10.534 65.020 32.824 1.00 32.89 ? 88 TYR A OH 1 ATOM 707 N N . LYS A 1 89 ? -13.919 69.533 39.560 1.00 42.77 ? 89 LYS A N 1 ATOM 708 C CA . LYS A 1 89 ? -14.298 69.931 40.913 1.00 47.41 ? 89 LYS A CA 1 ATOM 709 C C . LYS A 1 89 ? -13.110 69.862 41.863 1.00 48.91 ? 89 LYS A C 1 ATOM 710 O O . LYS A 1 89 ? -13.196 69.232 42.915 1.00 50.07 ? 89 LYS A O 1 ATOM 711 C CB . LYS A 1 89 ? -15.397 69.006 41.442 1.00 48.64 ? 89 LYS A CB 1 ATOM 712 C CG . LYS A 1 89 ? -16.634 68.946 40.572 1.00 52.29 ? 89 LYS A CG 1 ATOM 713 C CD . LYS A 1 89 ? -17.595 67.880 41.069 1.00 54.97 ? 89 LYS A CD 1 ATOM 714 C CE . LYS A 1 89 ? -18.882 67.885 40.260 1.00 57.04 ? 89 LYS A CE 1 ATOM 715 N NZ . LYS A 1 89 ? -19.852 66.878 40.767 1.00 58.99 ? 89 LYS A NZ 1 ATOM 716 N N . ASP A 1 90 ? -12.006 70.505 41.503 1.00 49.81 ? 90 ASP A N 1 ATOM 717 C CA . ASP A 1 90 ? -10.835 70.462 42.362 1.00 51.04 ? 90 ASP A CA 1 ATOM 718 C C . ASP A 1 90 ? -10.049 71.769 42.412 1.00 51.11 ? 90 ASP A C 1 ATOM 719 O O . ASP A 1 90 ? -8.838 71.782 42.202 1.00 50.14 ? 90 ASP A O 1 ATOM 720 C CB . ASP A 1 90 ? -9.922 69.311 41.929 1.00 53.87 ? 90 ASP A CB 1 ATOM 721 C CG . ASP A 1 90 ? -8.746 69.121 42.862 1.00 55.70 ? 90 ASP A CG 1 ATOM 722 O OD1 . ASP A 1 90 ? -8.881 69.479 44.051 1.00 60.03 ? 90 ASP A OD1 1 ATOM 723 O OD2 . ASP A 1 90 ? -7.697 68.608 42.419 1.00 56.16 ? 90 ASP A OD2 1 ATOM 724 N N . SER A 1 91 ? -10.745 72.864 42.709 1.00 52.29 ? 91 SER A N 1 ATOM 725 C CA . SER A 1 91 ? -10.114 74.175 42.803 1.00 53.85 ? 91 SER A CA 1 ATOM 726 C C . SER A 1 91 ? -9.185 74.274 44.012 1.00 54.08 ? 91 SER A C 1 ATOM 727 O O . SER A 1 91 ? -8.307 75.132 44.053 1.00 54.85 ? 91 SER A O 1 ATOM 728 C CB . SER A 1 91 ? -11.173 75.267 42.899 1.00 54.99 ? 91 SER A CB 1 ATOM 729 O OG . SER A 1 91 ? -11.904 75.137 44.102 1.00 58.54 ? 91 SER A OG 1 ATOM 730 N N . THR A 1 92 ? -9.378 73.406 44.999 1.00 53.93 ? 92 THR A N 1 ATOM 731 C CA . THR A 1 92 ? -8.527 73.428 46.186 1.00 54.29 ? 92 THR A CA 1 ATOM 732 C C . THR A 1 92 ? -7.146 72.881 45.847 1.00 52.90 ? 92 THR A C 1 ATOM 733 O O . THR A 1 92 ? -6.184 73.080 46.595 1.00 53.31 ? 92 THR A O 1 ATOM 734 C CB . THR A 1 92 ? -9.125 72.585 47.341 1.00 55.44 ? 92 THR A CB 1 ATOM 735 O OG1 . THR A 1 92 ? -9.302 71.228 46.911 1.00 57.39 ? 92 THR A OG1 1 ATOM 736 C CG2 . THR A 1 92 ? -10.465 73.160 47.780 1.00 55.78 ? 92 THR A CG2 1 ATOM 737 N N . GLY A 1 93 ? -7.059 72.193 44.713 1.00 50.20 ? 93 GLY A N 1 ATOM 738 C CA . GLY A 1 93 ? -5.796 71.624 44.285 1.00 46.37 ? 93 GLY A CA 1 ATOM 739 C C . GLY A 1 93 ? -4.979 72.612 43.476 1.00 43.68 ? 93 GLY A C 1 ATOM 740 O O . GLY A 1 93 ? -5.452 73.686 43.124 1.00 43.21 ? 93 GLY A O 1 ATOM 741 N N . SER A 1 94 ? -3.739 72.246 43.186 1.00 42.01 ? 94 SER A N 1 ATOM 742 C CA . SER A 1 94 ? -2.850 73.102 42.412 1.00 39.57 ? 94 SER A CA 1 ATOM 743 C C . SER A 1 94 ? -2.660 72.427 41.053 1.00 36.07 ? 94 SER A C 1 ATOM 744 O O . SER A 1 94 ? -2.053 71.367 40.968 1.00 34.35 ? 94 SER A O 1 ATOM 745 C CB . SER A 1 94 ? -1.509 73.239 43.141 1.00 40.89 ? 94 SER A CB 1 ATOM 746 O OG . SER A 1 94 ? -0.666 74.187 42.510 1.00 45.44 ? 94 SER A OG 1 ATOM 747 N N . HIS A 1 95 ? -3.177 73.040 39.994 1.00 32.52 ? 95 HIS A N 1 ATOM 748 C CA . HIS A 1 95 ? -3.068 72.447 38.664 1.00 29.78 ? 95 HIS A CA 1 ATOM 749 C C . HIS A 1 95 ? -2.321 73.317 37.661 1.00 28.94 ? 95 HIS A C 1 ATOM 750 O O . HIS A 1 95 ? -2.120 74.515 37.882 1.00 27.82 ? 95 HIS A O 1 ATOM 751 C CB . HIS A 1 95 ? -4.472 72.122 38.157 1.00 28.97 ? 95 HIS A CB 1 ATOM 752 C CG . HIS A 1 95 ? -5.234 71.220 39.075 1.00 29.70 ? 95 HIS A CG 1 ATOM 753 N ND1 . HIS A 1 95 ? -5.046 69.853 39.100 1.00 30.13 ? 95 HIS A ND1 1 ATOM 754 C CD2 . HIS A 1 95 ? -6.139 71.494 40.045 1.00 27.40 ? 95 HIS A CD2 1 ATOM 755 C CE1 . HIS A 1 95 ? -5.805 69.325 40.045 1.00 30.18 ? 95 HIS A CE1 1 ATOM 756 N NE2 . HIS A 1 95 ? -6.477 70.300 40.633 1.00 29.36 ? 95 HIS A NE2 1 ATOM 757 N N . VAL A 1 96 ? -1.907 72.709 36.554 1.00 25.11 ? 96 VAL A N 1 ATOM 758 C CA . VAL A 1 96 ? -1.160 73.441 35.540 1.00 23.48 ? 96 VAL A CA 1 ATOM 759 C C . VAL A 1 96 ? -1.634 73.128 34.117 1.00 24.41 ? 96 VAL A C 1 ATOM 760 O O . VAL A 1 96 ? -2.076 72.015 33.822 1.00 25.05 ? 96 VAL A O 1 ATOM 761 C CB . VAL A 1 96 ? 0.358 73.128 35.659 1.00 23.87 ? 96 VAL A CB 1 ATOM 762 C CG1 . VAL A 1 96 ? 0.586 71.616 35.564 1.00 24.85 ? 96 VAL A CG1 1 ATOM 763 C CG2 . VAL A 1 96 ? 1.148 73.844 34.562 1.00 23.08 ? 96 VAL A CG2 1 ATOM 764 N N . LEU A 1 97 ? -1.565 74.138 33.259 1.00 23.93 ? 97 LEU A N 1 ATOM 765 C CA . LEU A 1 97 ? -1.929 74.007 31.855 1.00 22.79 ? 97 LEU A CA 1 ATOM 766 C C . LEU A 1 97 ? -0.743 74.578 31.091 1.00 23.43 ? 97 LEU A C 1 ATOM 767 O O . LEU A 1 97 ? -0.265 75.666 31.403 1.00 22.76 ? 97 LEU A O 1 ATOM 768 C CB . LEU A 1 97 ? -3.191 74.821 31.517 1.00 22.02 ? 97 LEU A CB 1 ATOM 769 C CG . LEU A 1 97 ? -3.657 74.734 30.050 1.00 22.58 ? 97 LEU A CG 1 ATOM 770 C CD1 . LEU A 1 97 ? -4.158 73.316 29.777 1.00 19.64 ? 97 LEU A CD1 1 ATOM 771 C CD2 . LEU A 1 97 ? -4.774 75.759 29.753 1.00 22.64 ? 97 LEU A CD2 1 ATOM 772 N N . GLN A 1 98 ? -0.245 73.826 30.119 1.00 22.22 ? 98 GLN A N 1 ATOM 773 C CA . GLN A 1 98 ? 0.862 74.288 29.303 1.00 21.96 ? 98 GLN A CA 1 ATOM 774 C C . GLN A 1 98 ? 0.414 74.188 27.851 1.00 23.05 ? 98 GLN A C 1 ATOM 775 O O . GLN A 1 98 ? -0.295 73.251 27.469 1.00 24.93 ? 98 GLN A O 1 ATOM 776 C CB . GLN A 1 98 ? 2.116 73.446 29.581 1.00 21.86 ? 98 GLN A CB 1 ATOM 777 C CG . GLN A 1 98 ? 2.730 73.795 30.952 1.00 23.45 ? 98 GLN A CG 1 ATOM 778 C CD . GLN A 1 98 ? 3.652 72.723 31.508 1.00 22.38 ? 98 GLN A CD 1 ATOM 779 O OE1 . GLN A 1 98 ? 4.855 72.938 31.651 1.00 27.02 ? 98 GLN A OE1 1 ATOM 780 N NE2 . GLN A 1 98 ? 3.092 71.565 31.824 1.00 20.07 ? 98 GLN A NE2 1 ATOM 781 N N . GLY A 1 99 ? 0.794 75.176 27.053 1.00 21.23 ? 99 GLY A N 1 ATOM 782 C CA . GLY A 1 99 ? 0.406 75.184 25.658 1.00 21.27 ? 99 GLY A CA 1 ATOM 783 C C . GLY A 1 99 ? 1.621 75.486 24.814 1.00 22.77 ? 99 GLY A C 1 ATOM 784 O O . GLY A 1 99 ? 2.440 76.327 25.173 1.00 21.73 ? 99 GLY A O 1 ATOM 785 N N . ARG A 1 100 ? 1.737 74.792 23.691 1.00 21.38 ? 100 ARG A N 1 ATOM 786 C CA . ARG A 1 100 ? 2.863 74.973 22.796 1.00 23.02 ? 100 ARG A CA 1 ATOM 787 C C . ARG A 1 100 ? 2.309 75.186 21.394 1.00 23.47 ? 100 ARG A C 1 ATOM 788 O O . ARG A 1 100 ? 1.424 74.452 20.958 1.00 21.43 ? 100 ARG A O 1 ATOM 789 C CB . ARG A 1 100 ? 3.731 73.712 22.847 1.00 24.60 ? 100 ARG A CB 1 ATOM 790 C CG . ARG A 1 100 ? 4.901 73.693 21.909 1.00 30.78 ? 100 ARG A CG 1 ATOM 791 C CD . ARG A 1 100 ? 5.741 72.432 22.120 1.00 32.69 ? 100 ARG A CD 1 ATOM 792 N NE . ARG A 1 100 ? 6.833 72.373 21.157 1.00 35.94 ? 100 ARG A NE 1 ATOM 793 C CZ . ARG A 1 100 ? 6.745 71.765 19.982 1.00 37.31 ? 100 ARG A CZ 1 ATOM 794 N NH1 . ARG A 1 100 ? 5.618 71.150 19.638 1.00 37.27 ? 100 ARG A NH1 1 ATOM 795 N NH2 . ARG A 1 100 ? 7.766 71.800 19.138 1.00 35.57 ? 100 ARG A NH2 1 ATOM 796 N N . PHE A 1 101 ? 2.800 76.204 20.696 1.00 25.07 ? 101 PHE A N 1 ATOM 797 C CA . PHE A 1 101 ? 2.327 76.455 19.338 1.00 24.70 ? 101 PHE A CA 1 ATOM 798 C C . PHE A 1 101 ? 3.372 77.216 18.541 1.00 25.88 ? 101 PHE A C 1 ATOM 799 O O . PHE A 1 101 ? 4.176 77.958 19.101 1.00 23.21 ? 101 PHE A O 1 ATOM 800 C CB . PHE A 1 101 ? 0.977 77.197 19.348 1.00 25.23 ? 101 PHE A CB 1 ATOM 801 C CG . PHE A 1 101 ? 1.021 78.572 19.959 1.00 26.10 ? 101 PHE A CG 1 ATOM 802 C CD1 . PHE A 1 101 ? 1.215 79.699 19.159 1.00 28.18 ? 101 PHE A CD1 1 ATOM 803 C CD2 . PHE A 1 101 ? 0.847 78.744 21.329 1.00 27.16 ? 101 PHE A CD2 1 ATOM 804 C CE1 . PHE A 1 101 ? 1.234 80.979 19.714 1.00 28.03 ? 101 PHE A CE1 1 ATOM 805 C CE2 . PHE A 1 101 ? 0.865 80.022 21.898 1.00 28.58 ? 101 PHE A CE2 1 ATOM 806 C CZ . PHE A 1 101 ? 1.058 81.143 21.088 1.00 29.39 ? 101 PHE A CZ 1 ATOM 807 N N . GLY A 1 102 ? 3.375 77.001 17.231 1.00 23.76 ? 102 GLY A N 1 ATOM 808 C CA . GLY A 1 102 ? 4.348 77.661 16.391 1.00 23.52 ? 102 GLY A CA 1 ATOM 809 C C . GLY A 1 102 ? 4.400 77.002 15.032 1.00 25.53 ? 102 GLY A C 1 ATOM 810 O O . GLY A 1 102 ? 3.524 76.206 14.683 1.00 23.13 ? 102 GLY A O 1 ATOM 811 N N . CYS A 1 103 ? 5.425 77.327 14.257 1.00 23.34 ? 103 CYS A N 1 ATOM 812 C CA . CYS A 1 103 ? 5.550 76.757 12.931 1.00 26.71 ? 103 CYS A CA 1 ATOM 813 C C . CYS A 1 103 ? 7.005 76.766 12.514 1.00 28.25 ? 103 CYS A C 1 ATOM 814 O O . CYS A 1 103 ? 7.865 77.290 13.227 1.00 26.03 ? 103 CYS A O 1 ATOM 815 C CB . CYS A 1 103 ? 4.733 77.581 11.928 1.00 28.81 ? 103 CYS A CB 1 ATOM 816 S SG . CYS A 1 103 ? 5.349 79.284 11.709 1.00 33.72 ? 103 CYS A SG 1 ATOM 817 N N . GLU A 1 104 ? 7.282 76.187 11.355 1.00 27.81 ? 104 GLU A N 1 ATOM 818 C CA . GLU A 1 104 ? 8.641 76.163 10.853 1.00 32.38 ? 104 GLU A CA 1 ATOM 819 C C . GLU A 1 104 ? 8.675 76.264 9.344 1.00 33.02 ? 104 GLU A C 1 ATOM 820 O O . GLU A 1 104 ? 7.693 75.957 8.670 1.00 31.95 ? 104 GLU A O 1 ATOM 821 C CB . GLU A 1 104 ? 9.364 74.891 11.297 1.00 36.27 ? 104 GLU A CB 1 ATOM 822 C CG . GLU A 1 104 ? 8.678 73.603 10.927 1.00 44.86 ? 104 GLU A CG 1 ATOM 823 C CD . GLU A 1 104 ? 9.515 72.385 11.287 1.00 51.35 ? 104 GLU A CD 1 ATOM 824 O OE1 . GLU A 1 104 ? 10.613 72.230 10.704 1.00 52.65 ? 104 GLU A OE1 1 ATOM 825 O OE2 . GLU A 1 104 ? 9.077 71.589 12.151 1.00 51.78 ? 104 GLU A OE2 1 ATOM 826 N N . ILE A 1 105 ? 9.807 76.727 8.825 1.00 35.22 ? 105 ILE A N 1 ATOM 827 C CA . ILE A 1 105 ? 10.000 76.834 7.388 1.00 37.49 ? 105 ILE A CA 1 ATOM 828 C C . ILE A 1 105 ? 11.352 76.215 7.072 1.00 40.04 ? 105 ILE A C 1 ATOM 829 O O . ILE A 1 105 ? 12.232 76.142 7.931 1.00 38.55 ? 105 ILE A O 1 ATOM 830 C CB . ILE A 1 105 ? 10.001 78.301 6.889 1.00 38.64 ? 105 ILE A CB 1 ATOM 831 C CG1 . ILE A 1 105 ? 11.178 79.065 7.498 1.00 40.80 ? 105 ILE A CG1 1 ATOM 832 C CG2 . ILE A 1 105 ? 8.679 78.979 7.231 1.00 37.72 ? 105 ILE A CG2 1 ATOM 833 C CD1 . ILE A 1 105 ? 11.302 80.492 6.990 1.00 44.68 ? 105 ILE A CD1 1 ATOM 834 N N . GLU A 1 106 ? 11.498 75.750 5.842 1.00 41.68 ? 106 GLU A N 1 ATOM 835 C CA . GLU A 1 106 ? 12.740 75.154 5.382 1.00 46.62 ? 106 GLU A CA 1 ATOM 836 C C . GLU A 1 106 ? 12.799 75.488 3.903 1.00 47.81 ? 106 GLU A C 1 ATOM 837 O O . GLU A 1 106 ? 11.860 75.195 3.164 1.00 47.43 ? 106 GLU A O 1 ATOM 838 C CB . GLU A 1 106 ? 12.725 73.638 5.597 1.00 49.57 ? 106 GLU A CB 1 ATOM 839 C CG . GLU A 1 106 ? 13.955 72.926 5.048 1.00 56.00 ? 106 GLU A CG 1 ATOM 840 C CD . GLU A 1 106 ? 14.116 71.514 5.592 1.00 59.28 ? 106 GLU A CD 1 ATOM 841 O OE1 . GLU A 1 106 ? 13.132 70.743 5.563 1.00 61.13 ? 106 GLU A OE1 1 ATOM 842 O OE2 . GLU A 1 106 ? 15.232 71.172 6.044 1.00 60.21 ? 106 GLU A OE2 1 ATOM 843 N N . ASN A 1 107 ? 13.885 76.128 3.481 1.00 50.33 ? 107 ASN A N 1 ATOM 844 C CA . ASN A 1 107 ? 14.038 76.519 2.084 1.00 51.76 ? 107 ASN A CA 1 ATOM 845 C C . ASN A 1 107 ? 12.917 77.484 1.706 1.00 51.81 ? 107 ASN A C 1 ATOM 846 O O . ASN A 1 107 ? 12.360 77.400 0.614 1.00 52.34 ? 107 ASN A O 1 ATOM 847 C CB . ASN A 1 107 ? 13.990 75.279 1.188 1.00 54.14 ? 107 ASN A CB 1 ATOM 848 C CG . ASN A 1 107 ? 15.142 74.325 1.452 1.00 57.59 ? 107 ASN A CG 1 ATOM 849 O OD1 . ASN A 1 107 ? 15.074 73.141 1.118 1.00 58.68 ? 107 ASN A OD1 1 ATOM 850 N ND2 . ASN A 1 107 ? 16.213 74.840 2.047 1.00 59.83 ? 107 ASN A ND2 1 ATOM 851 N N . ASN A 1 108 ? 12.586 78.391 2.623 1.00 51.97 ? 108 ASN A N 1 ATOM 852 C CA . ASN A 1 108 ? 11.530 79.380 2.407 1.00 52.99 ? 108 ASN A CA 1 ATOM 853 C C . ASN A 1 108 ? 10.144 78.731 2.262 1.00 51.89 ? 108 ASN A C 1 ATOM 854 O O . ASN A 1 108 ? 9.172 79.388 1.902 1.00 52.39 ? 108 ASN A O 1 ATOM 855 C CB . ASN A 1 108 ? 11.877 80.241 1.178 1.00 56.34 ? 108 ASN A CB 1 ATOM 856 C CG . ASN A 1 108 ? 10.747 81.175 0.760 1.00 60.84 ? 108 ASN A CG 1 ATOM 857 O OD1 . ASN A 1 108 ? 9.747 80.735 0.190 1.00 66.39 ? 108 ASN A OD1 1 ATOM 858 N ND2 . ASN A 1 108 ? 10.900 82.468 1.025 1.00 60.74 ? 108 ASN A ND2 1 ATOM 859 N N . ARG A 1 109 ? 10.047 77.445 2.577 1.00 48.89 ? 109 ARG A N 1 ATOM 860 C CA . ARG A 1 109 ? 8.770 76.738 2.472 1.00 47.66 ? 109 ARG A CA 1 ATOM 861 C C . ARG A 1 109 ? 8.240 76.268 3.833 1.00 44.04 ? 109 ARG A C 1 ATOM 862 O O . ARG A 1 109 ? 8.974 75.646 4.604 1.00 42.38 ? 109 ARG A O 1 ATOM 863 C CB . ARG A 1 109 ? 8.927 75.517 1.559 1.00 50.40 ? 109 ARG A CB 1 ATOM 864 C CG . ARG A 1 109 ? 9.301 75.836 0.123 1.00 56.77 ? 109 ARG A CG 1 ATOM 865 C CD . ARG A 1 109 ? 8.104 76.354 -0.655 1.00 61.99 ? 109 ARG A CD 1 ATOM 866 N NE . ARG A 1 109 ? 8.445 76.651 -2.043 1.00 66.69 ? 109 ARG A NE 1 ATOM 867 C CZ . ARG A 1 109 ? 7.555 76.966 -2.979 1.00 68.90 ? 109 ARG A CZ 1 ATOM 868 N NH1 . ARG A 1 109 ? 6.265 77.023 -2.675 1.00 70.72 ? 109 ARG A NH1 1 ATOM 869 N NH2 . ARG A 1 109 ? 7.953 77.223 -4.217 1.00 69.32 ? 109 ARG A NH2 1 ATOM 870 N N . SER A 1 110 ? 6.976 76.563 4.129 1.00 40.76 ? 110 SER A N 1 ATOM 871 C CA . SER A 1 110 ? 6.385 76.109 5.386 1.00 40.16 ? 110 SER A CA 1 ATOM 872 C C . SER A 1 110 ? 6.607 74.608 5.438 1.00 38.52 ? 110 SER A C 1 ATOM 873 O O . SER A 1 110 ? 6.250 73.893 4.503 1.00 39.94 ? 110 SER A O 1 ATOM 874 C CB . SER A 1 110 ? 4.884 76.400 5.430 1.00 38.99 ? 110 SER A CB 1 ATOM 875 O OG . SER A 1 110 ? 4.635 77.771 5.670 1.00 37.84 ? 110 SER A OG 1 ATOM 876 N N . SER A 1 111 ? 7.209 74.131 6.519 1.00 36.52 ? 111 SER A N 1 ATOM 877 C CA . SER A 1 111 ? 7.492 72.711 6.651 1.00 35.06 ? 111 SER A CA 1 ATOM 878 C C . SER A 1 111 ? 6.914 72.076 7.904 1.00 34.25 ? 111 SER A C 1 ATOM 879 O O . SER A 1 111 ? 7.147 70.899 8.158 1.00 35.81 ? 111 SER A O 1 ATOM 880 C CB . SER A 1 111 ? 9.001 72.481 6.626 1.00 33.55 ? 111 SER A CB 1 ATOM 881 O OG . SER A 1 111 ? 9.644 73.284 7.601 1.00 36.47 ? 111 SER A OG 1 ATOM 882 N N . GLY A 1 112 ? 6.173 72.847 8.691 1.00 34.82 ? 112 GLY A N 1 ATOM 883 C CA . GLY A 1 112 ? 5.591 72.296 9.900 1.00 31.25 ? 112 GLY A CA 1 ATOM 884 C C . GLY A 1 112 ? 4.848 73.312 10.744 1.00 31.36 ? 112 GLY A C 1 ATOM 885 O O . GLY A 1 112 ? 5.089 74.516 10.644 1.00 29.55 ? 112 GLY A O 1 ATOM 886 N N . ALA A 1 113 ? 3.928 72.819 11.571 1.00 27.96 ? 113 ALA A N 1 ATOM 887 C CA . ALA A 1 113 ? 3.144 73.674 12.456 1.00 26.84 ? 113 ALA A CA 1 ATOM 888 C C . ALA A 1 113 ? 2.552 72.795 13.548 1.00 25.34 ? 113 ALA A C 1 ATOM 889 O O . ALA A 1 113 ? 2.337 71.601 13.347 1.00 23.45 ? 113 ALA A O 1 ATOM 890 C CB . ALA A 1 113 ? 2.040 74.380 11.679 1.00 24.58 ? 113 ALA A CB 1 ATOM 891 N N . PHE A 1 114 ? 2.285 73.382 14.707 1.00 23.82 ? 114 PHE A N 1 ATOM 892 C CA . PHE A 1 114 ? 1.754 72.602 15.812 1.00 24.16 ? 114 PHE A CA 1 ATOM 893 C C . PHE A 1 114 ? 1.033 73.505 16.793 1.00 23.45 ? 114 PHE A C 1 ATOM 894 O O . PHE A 1 114 ? 1.292 74.704 16.860 1.00 22.75 ? 114 PHE A O 1 ATOM 895 C CB . PHE A 1 114 ? 2.908 71.866 16.499 1.00 25.96 ? 114 PHE A CB 1 ATOM 896 C CG . PHE A 1 114 ? 4.052 72.765 16.864 1.00 27.76 ? 114 PHE A CG 1 ATOM 897 C CD1 . PHE A 1 114 ? 4.016 73.516 18.028 1.00 28.40 ? 114 PHE A CD1 1 ATOM 898 C CD2 . PHE A 1 114 ? 5.127 72.922 16.001 1.00 27.77 ? 114 PHE A CD2 1 ATOM 899 C CE1 . PHE A 1 114 ? 5.031 74.414 18.329 1.00 28.39 ? 114 PHE A CE1 1 ATOM 900 C CE2 . PHE A 1 114 ? 6.150 73.819 16.292 1.00 30.34 ? 114 PHE A CE2 1 ATOM 901 C CZ . PHE A 1 114 ? 6.102 74.569 17.460 1.00 27.29 ? 114 PHE A CZ 1 ATOM 902 N N . TRP A 1 115 ? 0.125 72.916 17.558 1.00 20.49 ? 115 TRP A N 1 ATOM 903 C CA . TRP A 1 115 ? -0.659 73.665 18.523 1.00 19.40 ? 115 TRP A CA 1 ATOM 904 C C . TRP A 1 115 ? -1.228 72.586 19.430 1.00 20.55 ? 115 TRP A C 1 ATOM 905 O O . TRP A 1 115 ? -2.143 71.859 19.036 1.00 20.65 ? 115 TRP A O 1 ATOM 906 C CB . TRP A 1 115 ? -1.786 74.395 17.784 1.00 19.54 ? 115 TRP A CB 1 ATOM 907 C CG . TRP A 1 115 ? -2.433 75.523 18.530 1.00 22.02 ? 115 TRP A CG 1 ATOM 908 C CD1 . TRP A 1 115 ? -2.420 75.742 19.881 1.00 21.21 ? 115 TRP A CD1 1 ATOM 909 C CD2 . TRP A 1 115 ? -3.235 76.563 17.961 1.00 22.79 ? 115 TRP A CD2 1 ATOM 910 N NE1 . TRP A 1 115 ? -3.166 76.857 20.185 1.00 23.98 ? 115 TRP A NE1 1 ATOM 911 C CE2 . TRP A 1 115 ? -3.678 77.381 19.025 1.00 23.35 ? 115 TRP A CE2 1 ATOM 912 C CE3 . TRP A 1 115 ? -3.622 76.884 16.651 1.00 23.49 ? 115 TRP A CE3 1 ATOM 913 C CZ2 . TRP A 1 115 ? -4.492 78.506 18.821 1.00 24.05 ? 115 TRP A CZ2 1 ATOM 914 C CZ3 . TRP A 1 115 ? -4.432 78.003 16.446 1.00 23.91 ? 115 TRP A CZ3 1 ATOM 915 C CH2 . TRP A 1 115 ? -4.857 78.800 17.529 1.00 25.68 ? 115 TRP A CH2 1 ATOM 916 N N . LYS A 1 116 ? -0.683 72.471 20.636 1.00 21.47 ? 116 LYS A N 1 ATOM 917 C CA . LYS A 1 116 ? -1.127 71.436 21.563 1.00 20.16 ? 116 LYS A CA 1 ATOM 918 C C . LYS A 1 116 ? -1.075 71.913 23.011 1.00 22.10 ? 116 LYS A C 1 ATOM 919 O O . LYS A 1 116 ? -0.227 72.733 23.371 1.00 20.41 ? 116 LYS A O 1 ATOM 920 C CB . LYS A 1 116 ? -0.233 70.201 21.379 1.00 20.50 ? 116 LYS A CB 1 ATOM 921 C CG . LYS A 1 116 ? -0.578 68.993 22.251 1.00 20.31 ? 116 LYS A CG 1 ATOM 922 C CD . LYS A 1 116 ? 0.300 67.791 21.856 1.00 21.48 ? 116 LYS A CD 1 ATOM 923 C CE . LYS A 1 116 ? 0.024 66.556 22.712 1.00 22.32 ? 116 LYS A CE 1 ATOM 924 N NZ . LYS A 1 116 ? 0.883 65.384 22.320 1.00 22.18 ? 116 LYS A NZ 1 ATOM 925 N N . TYR A 1 117 ? -1.995 71.405 23.830 1.00 22.12 ? 117 TYR A N 1 ATOM 926 C CA . TYR A 1 117 ? -2.053 71.770 25.240 1.00 22.36 ? 117 TYR A CA 1 ATOM 927 C C . TYR A 1 117 ? -1.893 70.525 26.102 1.00 23.43 ? 117 TYR A C 1 ATOM 928 O O . TYR A 1 117 ? -2.278 69.413 25.693 1.00 21.42 ? 117 TYR A O 1 ATOM 929 C CB . TYR A 1 117 ? -3.385 72.447 25.578 1.00 22.87 ? 117 TYR A CB 1 ATOM 930 C CG . TYR A 1 117 ? -3.618 73.759 24.869 1.00 23.73 ? 117 TYR A CG 1 ATOM 931 C CD1 . TYR A 1 117 ? -3.995 73.792 23.532 1.00 23.58 ? 117 TYR A CD1 1 ATOM 932 C CD2 . TYR A 1 117 ? -3.441 74.972 25.534 1.00 25.13 ? 117 TYR A CD2 1 ATOM 933 C CE1 . TYR A 1 117 ? -4.196 75.000 22.868 1.00 23.13 ? 117 TYR A CE1 1 ATOM 934 C CE2 . TYR A 1 117 ? -3.630 76.191 24.876 1.00 23.23 ? 117 TYR A CE2 1 ATOM 935 C CZ . TYR A 1 117 ? -4.007 76.193 23.547 1.00 24.54 ? 117 TYR A CZ 1 ATOM 936 O OH . TYR A 1 117 ? -4.183 77.384 22.887 1.00 21.78 ? 117 TYR A OH 1 ATOM 937 N N . TYR A 1 118 ? -1.337 70.729 27.295 1.00 21.45 ? 118 TYR A N 1 ATOM 938 C CA . TYR A 1 118 ? -1.095 69.659 28.262 1.00 20.88 ? 118 TYR A CA 1 ATOM 939 C C . TYR A 1 118 ? -1.657 70.109 29.614 1.00 22.98 ? 118 TYR A C 1 ATOM 940 O O . TYR A 1 118 ? -1.390 71.232 30.055 1.00 21.85 ? 118 TYR A O 1 ATOM 941 C CB . TYR A 1 118 ? 0.414 69.402 28.419 1.00 20.91 ? 118 TYR A CB 1 ATOM 942 C CG . TYR A 1 118 ? 1.172 69.246 27.112 1.00 21.47 ? 118 TYR A CG 1 ATOM 943 C CD1 . TYR A 1 118 ? 1.497 70.358 26.335 1.00 21.69 ? 118 TYR A CD1 1 ATOM 944 C CD2 . TYR A 1 118 ? 1.543 67.982 26.646 1.00 21.12 ? 118 TYR A CD2 1 ATOM 945 C CE1 . TYR A 1 118 ? 2.179 70.223 25.120 1.00 20.93 ? 118 TYR A CE1 1 ATOM 946 C CE2 . TYR A 1 118 ? 2.222 67.831 25.433 1.00 24.13 ? 118 TYR A CE2 1 ATOM 947 C CZ . TYR A 1 118 ? 2.540 68.957 24.678 1.00 23.67 ? 118 TYR A CZ 1 ATOM 948 O OH . TYR A 1 118 ? 3.245 68.814 23.506 1.00 21.53 ? 118 TYR A OH 1 ATOM 949 N N . TYR A 1 119 ? -2.416 69.231 30.267 1.00 20.09 ? 119 TYR A N 1 ATOM 950 C CA . TYR A 1 119 ? -3.023 69.535 31.563 1.00 22.76 ? 119 TYR A CA 1 ATOM 951 C C . TYR A 1 119 ? -2.395 68.604 32.589 1.00 23.09 ? 119 TYR A C 1 ATOM 952 O O . TYR A 1 119 ? -2.465 67.385 32.451 1.00 21.42 ? 119 TYR A O 1 ATOM 953 C CB . TYR A 1 119 ? -4.540 69.315 31.510 1.00 21.81 ? 119 TYR A CB 1 ATOM 954 C CG . TYR A 1 119 ? -5.231 69.508 32.843 1.00 25.00 ? 119 TYR A CG 1 ATOM 955 C CD1 . TYR A 1 119 ? -5.242 70.752 33.470 1.00 25.08 ? 119 TYR A CD1 1 ATOM 956 C CD2 . TYR A 1 119 ? -5.861 68.438 33.484 1.00 27.15 ? 119 TYR A CD2 1 ATOM 957 C CE1 . TYR A 1 119 ? -5.865 70.930 34.705 1.00 28.64 ? 119 TYR A CE1 1 ATOM 958 C CE2 . TYR A 1 119 ? -6.485 68.604 34.719 1.00 29.95 ? 119 TYR A CE2 1 ATOM 959 C CZ . TYR A 1 119 ? -6.483 69.851 35.322 1.00 30.50 ? 119 TYR A CZ 1 ATOM 960 O OH . TYR A 1 119 ? -7.100 70.018 36.535 1.00 32.68 ? 119 TYR A OH 1 ATOM 961 N N . ASP A 1 120 ? -1.789 69.186 33.619 1.00 23.44 ? 120 ASP A N 1 ATOM 962 C CA . ASP A 1 120 ? -1.099 68.408 34.640 1.00 23.69 ? 120 ASP A CA 1 ATOM 963 C C . ASP A 1 120 ? -0.134 67.414 33.998 1.00 23.48 ? 120 ASP A C 1 ATOM 964 O O . ASP A 1 120 ? -0.004 66.277 34.439 1.00 24.30 ? 120 ASP A O 1 ATOM 965 C CB . ASP A 1 120 ? -2.097 67.689 35.553 1.00 22.99 ? 120 ASP A CB 1 ATOM 966 C CG . ASP A 1 120 ? -2.734 68.634 36.573 1.00 26.91 ? 120 ASP A CG 1 ATOM 967 O OD1 . ASP A 1 120 ? -2.261 69.787 36.686 1.00 25.97 ? 120 ASP A OD1 1 ATOM 968 O OD2 . ASP A 1 120 ? -3.694 68.232 37.264 1.00 28.39 ? 120 ASP A OD2 1 ATOM 969 N N . GLY A 1 121 ? 0.535 67.855 32.940 1.00 24.02 ? 121 GLY A N 1 ATOM 970 C CA . GLY A 1 121 ? 1.499 67.002 32.268 1.00 23.75 ? 121 GLY A CA 1 ATOM 971 C C . GLY A 1 121 ? 0.972 66.038 31.220 1.00 25.06 ? 121 GLY A C 1 ATOM 972 O O . GLY A 1 121 ? 1.762 65.483 30.468 1.00 26.39 ? 121 GLY A O 1 ATOM 973 N N . LYS A 1 122 ? -0.342 65.834 31.163 1.00 26.13 ? 122 LYS A N 1 ATOM 974 C CA . LYS A 1 122 ? -0.938 64.910 30.189 1.00 27.34 ? 122 LYS A CA 1 ATOM 975 C C . LYS A 1 122 ? -1.474 65.620 28.943 1.00 24.12 ? 122 LYS A C 1 ATOM 976 O O . LYS A 1 122 ? -1.932 66.761 29.017 1.00 22.94 ? 122 LYS A O 1 ATOM 977 C CB . LYS A 1 122 ? -2.102 64.134 30.820 1.00 28.35 ? 122 LYS A CB 1 ATOM 978 C CG . LYS A 1 122 ? -1.754 63.284 32.031 1.00 36.09 ? 122 LYS A CG 1 ATOM 979 C CD . LYS A 1 122 ? -1.558 64.146 33.270 1.00 45.27 ? 122 LYS A CD 1 ATOM 980 C CE . LYS A 1 122 ? -1.441 63.306 34.539 1.00 49.22 ? 122 LYS A CE 1 ATOM 981 N NZ . LYS A 1 122 ? -1.188 64.161 35.740 1.00 50.26 ? 122 LYS A NZ 1 ATOM 982 N N . ASP A 1 123 ? -1.440 64.937 27.804 1.00 23.60 ? 123 ASP A N 1 ATOM 983 C CA . ASP A 1 123 ? -1.959 65.527 26.570 1.00 24.06 ? 123 ASP A CA 1 ATOM 984 C C . ASP A 1 123 ? -3.411 65.944 26.837 1.00 24.09 ? 123 ASP A C 1 ATOM 985 O O . ASP A 1 123 ? -4.206 65.153 27.362 1.00 25.26 ? 123 ASP A O 1 ATOM 986 C CB . ASP A 1 123 ? -1.931 64.506 25.431 1.00 25.05 ? 123 ASP A CB 1 ATOM 987 C CG . ASP A 1 123 ? -0.524 64.165 24.975 1.00 26.72 ? 123 ASP A CG 1 ATOM 988 O OD1 . ASP A 1 123 ? 0.451 64.774 25.452 1.00 24.52 ? 123 ASP A OD1 1 ATOM 989 O OD2 . ASP A 1 123 ? -0.392 63.278 24.117 1.00 29.90 ? 123 ASP A OD2 1 ATOM 990 N N . TYR A 1 124 ? -3.763 67.171 26.475 1.00 22.07 ? 124 TYR A N 1 ATOM 991 C CA . TYR A 1 124 ? -5.120 67.657 26.702 1.00 21.18 ? 124 TYR A CA 1 ATOM 992 C C . TYR A 1 124 ? -5.936 67.823 25.410 1.00 21.24 ? 124 TYR A C 1 ATOM 993 O O . TYR A 1 124 ? -7.005 67.238 25.266 1.00 19.48 ? 124 TYR A O 1 ATOM 994 C CB . TYR A 1 124 ? -5.079 68.995 27.451 1.00 20.73 ? 124 TYR A CB 1 ATOM 995 C CG . TYR A 1 124 ? -6.457 69.504 27.823 1.00 23.82 ? 124 TYR A CG 1 ATOM 996 C CD1 . TYR A 1 124 ? -7.203 68.885 28.836 1.00 22.92 ? 124 TYR A CD1 1 ATOM 997 C CD2 . TYR A 1 124 ? -7.035 70.569 27.137 1.00 21.72 ? 124 TYR A CD2 1 ATOM 998 C CE1 . TYR A 1 124 ? -8.496 69.318 29.151 1.00 22.67 ? 124 TYR A CE1 1 ATOM 999 C CE2 . TYR A 1 124 ? -8.319 71.008 27.441 1.00 24.80 ? 124 TYR A CE2 1 ATOM 1000 C CZ . TYR A 1 124 ? -9.043 70.376 28.450 1.00 24.23 ? 124 TYR A CZ 1 ATOM 1001 O OH . TYR A 1 124 ? -10.310 70.807 28.745 1.00 25.98 ? 124 TYR A OH 1 ATOM 1002 N N . ILE A 1 125 ? -5.427 68.622 24.475 1.00 20.78 ? 125 ILE A N 1 ATOM 1003 C CA . ILE A 1 125 ? -6.127 68.875 23.212 1.00 21.18 ? 125 ILE A CA 1 ATOM 1004 C C . ILE A 1 125 ? -5.091 69.411 22.226 1.00 20.84 ? 125 ILE A C 1 ATOM 1005 O O . ILE A 1 125 ? -4.109 70.023 22.646 1.00 19.08 ? 125 ILE A O 1 ATOM 1006 C CB . ILE A 1 125 ? -7.249 69.943 23.416 1.00 21.23 ? 125 ILE A CB 1 ATOM 1007 C CG1 . ILE A 1 125 ? -8.270 69.890 22.280 1.00 19.07 ? 125 ILE A CG1 1 ATOM 1008 C CG2 . ILE A 1 125 ? -6.634 71.346 23.495 1.00 22.36 ? 125 ILE A CG2 1 ATOM 1009 C CD1 . ILE A 1 125 ? -9.479 70.796 22.525 1.00 20.31 ? 125 ILE A CD1 1 ATOM 1010 N N . GLU A 1 126 ? -5.292 69.164 20.931 1.00 18.90 ? 126 GLU A N 1 ATOM 1011 C CA . GLU A 1 126 ? -4.361 69.650 19.905 1.00 20.06 ? 126 GLU A CA 1 ATOM 1012 C C . GLU A 1 126 ? -5.137 69.956 18.624 1.00 21.80 ? 126 GLU A C 1 ATOM 1013 O O . GLU A 1 126 ? -6.191 69.370 18.363 1.00 23.47 ? 126 GLU A O 1 ATOM 1014 C CB . GLU A 1 126 ? -3.283 68.596 19.590 1.00 21.03 ? 126 GLU A CB 1 ATOM 1015 C CG . GLU A 1 126 ? -3.810 67.408 18.799 1.00 26.30 ? 126 GLU A CG 1 ATOM 1016 C CD . GLU A 1 126 ? -2.745 66.358 18.467 1.00 29.86 ? 126 GLU A CD 1 ATOM 1017 O OE1 . GLU A 1 126 ? -3.071 65.416 17.707 1.00 28.29 ? 126 GLU A OE1 1 ATOM 1018 O OE2 . GLU A 1 126 ? -1.599 66.459 18.957 1.00 25.25 ? 126 GLU A OE2 1 ATOM 1019 N N . PHE A 1 127 ? -4.613 70.861 17.811 1.00 21.18 ? 127 PHE A N 1 ATOM 1020 C CA . PHE A 1 127 ? -5.292 71.200 16.574 1.00 22.17 ? 127 PHE A CA 1 ATOM 1021 C C . PHE A 1 127 ? -4.716 70.437 15.381 1.00 22.98 ? 127 PHE A C 1 ATOM 1022 O O . PHE A 1 127 ? -3.504 70.367 15.192 1.00 20.74 ? 127 PHE A O 1 ATOM 1023 C CB . PHE A 1 127 ? -5.200 72.706 16.314 1.00 21.32 ? 127 PHE A CB 1 ATOM 1024 C CG . PHE A 1 127 ? -6.062 73.184 15.168 1.00 21.14 ? 127 PHE A CG 1 ATOM 1025 C CD1 . PHE A 1 127 ? -7.449 73.184 15.277 1.00 22.79 ? 127 PHE A CD1 1 ATOM 1026 C CD2 . PHE A 1 127 ? -5.484 73.636 13.984 1.00 20.44 ? 127 PHE A CD2 1 ATOM 1027 C CE1 . PHE A 1 127 ? -8.255 73.630 14.222 1.00 23.01 ? 127 PHE A CE1 1 ATOM 1028 C CE2 . PHE A 1 127 ? -6.282 74.087 12.918 1.00 20.07 ? 127 PHE A CE2 1 ATOM 1029 C CZ . PHE A 1 127 ? -7.664 74.085 13.037 1.00 22.41 ? 127 PHE A CZ 1 ATOM 1030 N N . ASN A 1 128 ? -5.601 69.830 14.602 1.00 23.37 ? 128 ASN A N 1 ATOM 1031 C CA . ASN A 1 128 ? -5.193 69.129 13.396 1.00 23.12 ? 128 ASN A CA 1 ATOM 1032 C C . ASN A 1 128 ? -5.752 70.012 12.275 1.00 22.70 ? 128 ASN A C 1 ATOM 1033 O O . ASN A 1 128 ? -6.951 69.993 11.987 1.00 24.66 ? 128 ASN A O 1 ATOM 1034 C CB . ASN A 1 128 ? -5.805 67.725 13.329 1.00 22.71 ? 128 ASN A CB 1 ATOM 1035 C CG . ASN A 1 128 ? -5.344 66.957 12.106 1.00 24.16 ? 128 ASN A CG 1 ATOM 1036 O OD1 . ASN A 1 128 ? -5.272 67.514 11.014 1.00 26.42 ? 128 ASN A OD1 1 ATOM 1037 N ND2 . ASN A 1 128 ? -5.037 65.681 12.279 1.00 23.94 ? 128 ASN A ND2 1 ATOM 1038 N N . LYS A 1 129 ? -4.881 70.793 11.654 1.00 23.08 ? 129 LYS A N 1 ATOM 1039 C CA . LYS A 1 129 ? -5.297 71.715 10.606 1.00 22.61 ? 129 LYS A CA 1 ATOM 1040 C C . LYS A 1 129 ? -5.771 71.081 9.303 1.00 23.76 ? 129 LYS A C 1 ATOM 1041 O O . LYS A 1 129 ? -6.371 71.761 8.471 1.00 22.40 ? 129 LYS A O 1 ATOM 1042 C CB . LYS A 1 129 ? -4.164 72.697 10.311 1.00 24.91 ? 129 LYS A CB 1 ATOM 1043 C CG . LYS A 1 129 ? -2.918 72.062 9.698 1.00 28.93 ? 129 LYS A CG 1 ATOM 1044 C CD . LYS A 1 129 ? -1.768 73.063 9.695 1.00 32.00 ? 129 LYS A CD 1 ATOM 1045 C CE . LYS A 1 129 ? -0.546 72.521 8.967 1.00 33.45 ? 129 LYS A CE 1 ATOM 1046 N NZ . LYS A 1 129 ? -0.825 72.336 7.521 1.00 37.58 ? 129 LYS A NZ 1 ATOM 1047 N N . GLU A 1 130 ? -5.505 69.792 9.119 1.00 23.12 ? 130 GLU A N 1 ATOM 1048 C CA . GLU A 1 130 ? -5.933 69.115 7.904 1.00 25.38 ? 130 GLU A CA 1 ATOM 1049 C C . GLU A 1 130 ? -7.429 68.811 7.929 1.00 27.07 ? 130 GLU A C 1 ATOM 1050 O O . GLU A 1 130 ? -8.084 68.778 6.883 1.00 25.31 ? 130 GLU A O 1 ATOM 1051 C CB . GLU A 1 130 ? -5.160 67.804 7.715 1.00 26.12 ? 130 GLU A CB 1 ATOM 1052 C CG . GLU A 1 130 ? -5.383 67.163 6.342 1.00 29.29 ? 130 GLU A CG 1 ATOM 1053 C CD . GLU A 1 130 ? -4.605 65.865 6.155 1.00 31.35 ? 130 GLU A CD 1 ATOM 1054 O OE1 . GLU A 1 130 ? -5.140 64.778 6.477 1.00 26.13 ? 130 GLU A OE1 1 ATOM 1055 O OE2 . GLU A 1 130 ? -3.450 65.938 5.690 1.00 32.47 ? 130 GLU A OE2 1 ATOM 1056 N N . ILE A 1 131 ? -7.984 68.607 9.122 1.00 26.52 ? 131 ILE A N 1 ATOM 1057 C CA . ILE A 1 131 ? -9.399 68.266 9.209 1.00 26.44 ? 131 ILE A CA 1 ATOM 1058 C C . ILE A 1 131 ? -10.373 69.355 8.723 1.00 28.50 ? 131 ILE A C 1 ATOM 1059 O O . ILE A 1 131 ? -11.204 69.088 7.859 1.00 30.03 ? 131 ILE A O 1 ATOM 1060 C CB . ILE A 1 131 ? -9.743 67.763 10.632 1.00 26.21 ? 131 ILE A CB 1 ATOM 1061 C CG1 . ILE A 1 131 ? -8.930 66.492 10.913 1.00 24.67 ? 131 ILE A CG1 1 ATOM 1062 C CG2 . ILE A 1 131 ? -11.230 67.451 10.741 1.00 26.01 ? 131 ILE A CG2 1 ATOM 1063 C CD1 . ILE A 1 131 ? -9.151 65.869 12.274 1.00 26.58 ? 131 ILE A CD1 1 ATOM 1064 N N . PRO A 1 132 ? -10.323 70.576 9.279 1.00 26.83 ? 132 PRO A N 1 ATOM 1065 C CA . PRO A 1 132 ? -9.477 71.126 10.341 1.00 26.22 ? 132 PRO A CA 1 ATOM 1066 C C . PRO A 1 132 ? -10.325 71.076 11.603 1.00 25.74 ? 132 PRO A C 1 ATOM 1067 O O . PRO A 1 132 ? -11.528 71.317 11.546 1.00 25.56 ? 132 PRO A O 1 ATOM 1068 C CB . PRO A 1 132 ? -9.236 72.552 9.882 1.00 25.97 ? 132 PRO A CB 1 ATOM 1069 C CG . PRO A 1 132 ? -10.584 72.916 9.295 1.00 27.66 ? 132 PRO A CG 1 ATOM 1070 C CD . PRO A 1 132 ? -10.962 71.664 8.510 1.00 27.42 ? 132 PRO A CD 1 ATOM 1071 N N . ALA A 1 133 ? -9.715 70.748 12.733 1.00 23.37 ? 133 ALA A N 1 ATOM 1072 C CA . ALA A 1 133 ? -10.464 70.675 13.976 1.00 21.72 ? 133 ALA A CA 1 ATOM 1073 C C . ALA A 1 133 ? -9.565 70.325 15.147 1.00 21.46 ? 133 ALA A C 1 ATOM 1074 O O . ALA A 1 133 ? -8.450 69.843 14.963 1.00 18.85 ? 133 ALA A O 1 ATOM 1075 C CB . ALA A 1 133 ? -11.567 69.622 13.854 1.00 22.69 ? 133 ALA A CB 1 ATOM 1076 N N . TRP A 1 134 ? -10.074 70.568 16.350 1.00 21.66 ? 134 TRP A N 1 ATOM 1077 C CA . TRP A 1 134 ? -9.364 70.240 17.571 1.00 20.89 ? 134 TRP A CA 1 ATOM 1078 C C . TRP A 1 134 ? -9.606 68.763 17.845 1.00 22.65 ? 134 TRP A C 1 ATOM 1079 O O . TRP A 1 134 ? -10.644 68.202 17.473 1.00 24.57 ? 134 TRP A O 1 ATOM 1080 C CB . TRP A 1 134 ? -9.873 71.095 18.747 1.00 19.55 ? 134 TRP A CB 1 ATOM 1081 C CG . TRP A 1 134 ? -9.483 72.532 18.610 1.00 18.61 ? 134 TRP A CG 1 ATOM 1082 C CD1 . TRP A 1 134 ? -10.208 73.532 18.011 1.00 18.94 ? 134 TRP A CD1 1 ATOM 1083 C CD2 . TRP A 1 134 ? -8.228 73.111 18.973 1.00 19.19 ? 134 TRP A CD2 1 ATOM 1084 N NE1 . TRP A 1 134 ? -9.476 74.688 17.972 1.00 19.76 ? 134 TRP A NE1 1 ATOM 1085 C CE2 . TRP A 1 134 ? -8.255 74.461 18.556 1.00 22.52 ? 134 TRP A CE2 1 ATOM 1086 C CE3 . TRP A 1 134 ? -7.077 72.618 19.606 1.00 21.72 ? 134 TRP A CE3 1 ATOM 1087 C CZ2 . TRP A 1 134 ? -7.169 75.333 18.752 1.00 21.11 ? 134 TRP A CZ2 1 ATOM 1088 C CZ3 . TRP A 1 134 ? -6.000 73.480 19.799 1.00 22.93 ? 134 TRP A CZ3 1 ATOM 1089 C CH2 . TRP A 1 134 ? -6.057 74.828 19.370 1.00 19.68 ? 134 TRP A CH2 1 ATOM 1090 N N . VAL A 1 135 ? -8.630 68.135 18.485 1.00 21.27 ? 135 VAL A N 1 ATOM 1091 C CA . VAL A 1 135 ? -8.684 66.724 18.811 1.00 19.61 ? 135 VAL A CA 1 ATOM 1092 C C . VAL A 1 135 ? -8.567 66.645 20.322 1.00 21.15 ? 135 VAL A C 1 ATOM 1093 O O . VAL A 1 135 ? -7.545 67.026 20.889 1.00 21.42 ? 135 VAL A O 1 ATOM 1094 C CB . VAL A 1 135 ? -7.492 65.981 18.161 1.00 21.07 ? 135 VAL A CB 1 ATOM 1095 C CG1 . VAL A 1 135 ? -7.569 64.493 18.455 1.00 19.83 ? 135 VAL A CG1 1 ATOM 1096 C CG2 . VAL A 1 135 ? -7.482 66.240 16.650 1.00 20.52 ? 135 VAL A CG2 1 ATOM 1097 N N . PRO A 1 136 ? -9.619 66.166 21.000 1.00 22.84 ? 136 PRO A N 1 ATOM 1098 C CA . PRO A 1 136 ? -9.583 66.063 22.460 1.00 23.72 ? 136 PRO A CA 1 ATOM 1099 C C . PRO A 1 136 ? -8.933 64.763 22.932 1.00 25.41 ? 136 PRO A C 1 ATOM 1100 O O . PRO A 1 136 ? -9.128 63.712 22.322 1.00 27.49 ? 136 PRO A O 1 ATOM 1101 C CB . PRO A 1 136 ? -11.055 66.127 22.828 1.00 23.77 ? 136 PRO A CB 1 ATOM 1102 C CG . PRO A 1 136 ? -11.671 65.280 21.733 1.00 24.43 ? 136 PRO A CG 1 ATOM 1103 C CD . PRO A 1 136 ? -10.932 65.738 20.474 1.00 22.75 ? 136 PRO A CD 1 ATOM 1104 N N . PHE A 1 137 ? -8.158 64.838 24.007 1.00 26.02 ? 137 PHE A N 1 ATOM 1105 C CA . PHE A 1 137 ? -7.503 63.656 24.563 1.00 29.98 ? 137 PHE A CA 1 ATOM 1106 C C . PHE A 1 137 ? -7.981 63.405 25.990 1.00 31.67 ? 137 PHE A C 1 ATOM 1107 O O . PHE A 1 137 ? -7.969 62.281 26.469 1.00 38.20 ? 137 PHE A O 1 ATOM 1108 C CB . PHE A 1 137 ? -5.987 63.832 24.560 1.00 27.67 ? 137 PHE A CB 1 ATOM 1109 C CG . PHE A 1 137 ? -5.407 64.048 23.190 1.00 28.43 ? 137 PHE A CG 1 ATOM 1110 C CD1 . PHE A 1 137 ? -5.588 63.099 22.188 1.00 27.14 ? 137 PHE A CD1 1 ATOM 1111 C CD2 . PHE A 1 137 ? -4.670 65.195 22.904 1.00 27.83 ? 137 PHE A CD2 1 ATOM 1112 C CE1 . PHE A 1 137 ? -5.042 63.288 20.914 1.00 26.49 ? 137 PHE A CE1 1 ATOM 1113 C CE2 . PHE A 1 137 ? -4.119 65.393 21.637 1.00 29.78 ? 137 PHE A CE2 1 ATOM 1114 C CZ . PHE A 1 137 ? -4.307 64.433 20.640 1.00 27.69 ? 137 PHE A CZ 1 ATOM 1115 N N . ASP A 1 138 ? -8.387 64.467 26.666 1.00 32.81 ? 138 ASP A N 1 ATOM 1116 C CA . ASP A 1 138 ? -8.875 64.378 28.036 1.00 31.45 ? 138 ASP A CA 1 ATOM 1117 C C . ASP A 1 138 ? -10.382 64.582 27.970 1.00 30.29 ? 138 ASP A C 1 ATOM 1118 O O . ASP A 1 138 ? -10.870 65.305 27.107 1.00 28.81 ? 138 ASP A O 1 ATOM 1119 C CB . ASP A 1 138 ? -8.216 65.478 28.871 1.00 30.02 ? 138 ASP A CB 1 ATOM 1120 C CG . ASP A 1 138 ? -8.623 65.441 30.328 1.00 31.42 ? 138 ASP A CG 1 ATOM 1121 O OD1 . ASP A 1 138 ? -9.705 65.966 30.676 1.00 30.15 ? 138 ASP A OD1 1 ATOM 1122 O OD2 . ASP A 1 138 ? -7.855 64.875 31.124 1.00 30.12 ? 138 ASP A OD2 1 ATOM 1123 N N . PRO A 1 139 ? -11.145 63.935 28.862 1.00 30.48 ? 139 PRO A N 1 ATOM 1124 C CA . PRO A 1 139 ? -12.593 64.145 28.788 1.00 29.94 ? 139 PRO A CA 1 ATOM 1125 C C . PRO A 1 139 ? -13.035 65.609 28.876 1.00 29.20 ? 139 PRO A C 1 ATOM 1126 O O . PRO A 1 139 ? -13.990 66.012 28.215 1.00 28.55 ? 139 PRO A O 1 ATOM 1127 C CB . PRO A 1 139 ? -13.145 63.270 29.930 1.00 31.52 ? 139 PRO A CB 1 ATOM 1128 C CG . PRO A 1 139 ? -11.950 62.940 30.778 1.00 35.06 ? 139 PRO A CG 1 ATOM 1129 C CD . PRO A 1 139 ? -10.816 62.847 29.795 1.00 32.44 ? 139 PRO A CD 1 ATOM 1130 N N . ALA A 1 140 ? -12.345 66.414 29.677 1.00 27.47 ? 140 ALA A N 1 ATOM 1131 C CA . ALA A 1 140 ? -12.715 67.818 29.793 1.00 25.83 ? 140 ALA A CA 1 ATOM 1132 C C . ALA A 1 140 ? -12.435 68.556 28.482 1.00 23.67 ? 140 ALA A C 1 ATOM 1133 O O . ALA A 1 140 ? -13.045 69.580 28.199 1.00 23.79 ? 140 ALA A O 1 ATOM 1134 C CB . ALA A 1 140 ? -11.950 68.482 30.947 1.00 25.05 ? 140 ALA A CB 1 ATOM 1135 N N . ALA A 1 141 ? -11.509 68.030 27.687 1.00 22.29 ? 141 ALA A N 1 ATOM 1136 C CA . ALA A 1 141 ? -11.159 68.649 26.415 1.00 21.66 ? 141 ALA A CA 1 ATOM 1137 C C . ALA A 1 141 ? -12.339 68.623 25.452 1.00 22.02 ? 141 ALA A C 1 ATOM 1138 O O . ALA A 1 141 ? -12.374 69.384 24.487 1.00 22.38 ? 141 ALA A O 1 ATOM 1139 C CB . ALA A 1 141 ? -9.956 67.940 25.790 1.00 19.97 ? 141 ALA A CB 1 ATOM 1140 N N . GLN A 1 142 ? -13.296 67.736 25.708 1.00 23.43 ? 142 GLN A N 1 ATOM 1141 C CA . GLN A 1 142 ? -14.480 67.638 24.867 1.00 23.83 ? 142 GLN A CA 1 ATOM 1142 C C . GLN A 1 142 ? -15.284 68.924 24.986 1.00 26.87 ? 142 GLN A C 1 ATOM 1143 O O . GLN A 1 142 ? -15.858 69.408 24.003 1.00 27.43 ? 142 GLN A O 1 ATOM 1144 C CB . GLN A 1 142 ? -15.346 66.456 25.304 1.00 24.13 ? 142 GLN A CB 1 ATOM 1145 C CG . GLN A 1 142 ? -14.761 65.100 24.980 1.00 26.77 ? 142 GLN A CG 1 ATOM 1146 C CD . GLN A 1 142 ? -15.669 63.975 25.424 1.00 26.21 ? 142 GLN A CD 1 ATOM 1147 O OE1 . GLN A 1 142 ? -16.886 64.142 25.491 1.00 27.58 ? 142 GLN A OE1 1 ATOM 1148 N NE2 . GLN A 1 142 ? -15.089 62.822 25.710 1.00 26.39 ? 142 GLN A NE2 1 ATOM 1149 N N . ILE A 1 143 ? -15.312 69.480 26.196 1.00 26.31 ? 143 ILE A N 1 ATOM 1150 C CA . ILE A 1 143 ? -16.036 70.717 26.455 1.00 26.74 ? 143 ILE A CA 1 ATOM 1151 C C . ILE A 1 143 ? -15.283 71.875 25.819 1.00 26.51 ? 143 ILE A C 1 ATOM 1152 O O . ILE A 1 143 ? -15.876 72.742 25.186 1.00 25.48 ? 143 ILE A O 1 ATOM 1153 C CB . ILE A 1 143 ? -16.165 70.991 27.970 1.00 28.87 ? 143 ILE A CB 1 ATOM 1154 C CG1 . ILE A 1 143 ? -16.893 69.830 28.652 1.00 30.91 ? 143 ILE A CG1 1 ATOM 1155 C CG2 . ILE A 1 143 ? -16.915 72.304 28.202 1.00 27.22 ? 143 ILE A CG2 1 ATOM 1156 C CD1 . ILE A 1 143 ? -18.289 69.613 28.141 1.00 37.16 ? 143 ILE A CD1 1 ATOM 1157 N N . THR A 1 144 ? -13.968 71.885 26.011 1.00 25.51 ? 144 THR A N 1 ATOM 1158 C CA . THR A 1 144 ? -13.112 72.919 25.449 1.00 25.38 ? 144 THR A CA 1 ATOM 1159 C C . THR A 1 144 ? -13.292 72.918 23.926 1.00 25.28 ? 144 THR A C 1 ATOM 1160 O O . THR A 1 144 ? -13.483 73.965 23.315 1.00 24.24 ? 144 THR A O 1 ATOM 1161 C CB . THR A 1 144 ? -11.633 72.641 25.793 1.00 25.42 ? 144 THR A CB 1 ATOM 1162 O OG1 . THR A 1 144 ? -11.486 72.550 27.216 1.00 25.59 ? 144 THR A OG1 1 ATOM 1163 C CG2 . THR A 1 144 ? -10.736 73.745 25.267 1.00 25.14 ? 144 THR A CG2 1 ATOM 1164 N N . LYS A 1 145 ? -13.231 71.736 23.323 1.00 23.74 ? 145 LYS A N 1 ATOM 1165 C CA . LYS A 1 145 ? -13.408 71.617 21.879 1.00 25.45 ? 145 LYS A CA 1 ATOM 1166 C C . LYS A 1 145 ? -14.735 72.260 21.463 1.00 26.51 ? 145 LYS A C 1 ATOM 1167 O O . LYS A 1 145 ? -14.788 73.060 20.531 1.00 25.63 ? 145 LYS A O 1 ATOM 1168 C CB . LYS A 1 145 ? -13.400 70.136 21.468 1.00 23.61 ? 145 LYS A CB 1 ATOM 1169 C CG . LYS A 1 145 ? -13.715 69.859 19.989 1.00 21.86 ? 145 LYS A CG 1 ATOM 1170 C CD . LYS A 1 145 ? -13.460 68.385 19.668 1.00 22.97 ? 145 LYS A CD 1 ATOM 1171 C CE . LYS A 1 145 ? -14.086 67.951 18.342 1.00 22.20 ? 145 LYS A CE 1 ATOM 1172 N NZ . LYS A 1 145 ? -13.579 68.740 17.172 1.00 23.08 ? 145 LYS A NZ 1 ATOM 1173 N N . GLN A 1 146 ? -15.804 71.902 22.168 1.00 28.73 ? 146 GLN A N 1 ATOM 1174 C CA . GLN A 1 146 ? -17.131 72.427 21.868 1.00 30.53 ? 146 GLN A CA 1 ATOM 1175 C C . GLN A 1 146 ? -17.120 73.954 21.857 1.00 30.31 ? 146 GLN A C 1 ATOM 1176 O O . GLN A 1 146 ? -17.678 74.576 20.953 1.00 28.98 ? 146 GLN A O 1 ATOM 1177 C CB . GLN A 1 146 ? -18.145 71.913 22.895 1.00 34.05 ? 146 GLN A CB 1 ATOM 1178 C CG . GLN A 1 146 ? -19.555 71.792 22.357 1.00 42.18 ? 146 GLN A CG 1 ATOM 1179 C CD . GLN A 1 146 ? -19.751 70.551 21.492 1.00 48.56 ? 146 GLN A CD 1 ATOM 1180 O OE1 . GLN A 1 146 ? -18.921 70.226 20.630 1.00 48.40 ? 146 GLN A OE1 1 ATOM 1181 N NE2 . GLN A 1 146 ? -20.861 69.853 21.715 1.00 50.00 ? 146 GLN A NE2 1 ATOM 1182 N N . LYS A 1 147 ? -16.474 74.561 22.852 1.00 30.17 ? 147 LYS A N 1 ATOM 1183 C CA . LYS A 1 147 ? -16.403 76.019 22.920 1.00 30.12 ? 147 LYS A CA 1 ATOM 1184 C C . LYS A 1 147 ? -15.532 76.621 21.828 1.00 29.39 ? 147 LYS A C 1 ATOM 1185 O O . LYS A 1 147 ? -15.860 77.668 21.271 1.00 28.74 ? 147 LYS A O 1 ATOM 1186 C CB . LYS A 1 147 ? -15.871 76.479 24.280 1.00 32.44 ? 147 LYS A CB 1 ATOM 1187 C CG . LYS A 1 147 ? -16.793 76.160 25.433 1.00 36.56 ? 147 LYS A CG 1 ATOM 1188 C CD . LYS A 1 147 ? -16.302 76.763 26.744 1.00 41.28 ? 147 LYS A CD 1 ATOM 1189 C CE . LYS A 1 147 ? -17.228 76.365 27.884 1.00 39.74 ? 147 LYS A CE 1 ATOM 1190 N NZ . LYS A 1 147 ? -16.771 76.929 29.176 1.00 48.06 ? 147 LYS A NZ 1 ATOM 1191 N N . TRP A 1 148 ? -14.420 75.964 21.517 1.00 28.61 ? 148 TRP A N 1 ATOM 1192 C CA . TRP A 1 148 ? -13.514 76.485 20.495 1.00 28.12 ? 148 TRP A CA 1 ATOM 1193 C C . TRP A 1 148 ? -14.006 76.282 19.063 1.00 27.14 ? 148 TRP A C 1 ATOM 1194 O O . TRP A 1 148 ? -13.364 76.741 18.116 1.00 26.20 ? 148 TRP A O 1 ATOM 1195 C CB . TRP A 1 148 ? -12.120 75.873 20.663 1.00 25.11 ? 148 TRP A CB 1 ATOM 1196 C CG . TRP A 1 148 ? -11.415 76.324 21.924 1.00 26.95 ? 148 TRP A CG 1 ATOM 1197 C CD1 . TRP A 1 148 ? -11.864 77.245 22.839 1.00 25.65 ? 148 TRP A CD1 1 ATOM 1198 C CD2 . TRP A 1 148 ? -10.135 75.885 22.396 1.00 25.53 ? 148 TRP A CD2 1 ATOM 1199 N NE1 . TRP A 1 148 ? -10.939 77.402 23.846 1.00 27.34 ? 148 TRP A NE1 1 ATOM 1200 C CE2 . TRP A 1 148 ? -9.870 76.581 23.601 1.00 26.16 ? 148 TRP A CE2 1 ATOM 1201 C CE3 . TRP A 1 148 ? -9.184 74.972 21.918 1.00 23.55 ? 148 TRP A CE3 1 ATOM 1202 C CZ2 . TRP A 1 148 ? -8.696 76.388 24.334 1.00 24.90 ? 148 TRP A CZ2 1 ATOM 1203 C CZ3 . TRP A 1 148 ? -8.016 74.783 22.647 1.00 22.32 ? 148 TRP A CZ3 1 ATOM 1204 C CH2 . TRP A 1 148 ? -7.783 75.488 23.843 1.00 22.05 ? 148 TRP A CH2 1 ATOM 1205 N N . GLU A 1 149 ? -15.140 75.603 18.910 1.00 26.98 ? 149 GLU A N 1 ATOM 1206 C CA . GLU A 1 149 ? -15.710 75.358 17.584 1.00 30.12 ? 149 GLU A CA 1 ATOM 1207 C C . GLU A 1 149 ? -17.193 75.740 17.556 1.00 30.62 ? 149 GLU A C 1 ATOM 1208 O O . GLU A 1 149 ? -17.959 75.238 16.733 1.00 31.46 ? 149 GLU A O 1 ATOM 1209 C CB . GLU A 1 149 ? -15.535 73.879 17.203 1.00 29.34 ? 149 GLU A CB 1 ATOM 1210 C CG . GLU A 1 149 ? -14.096 73.390 17.367 1.00 29.39 ? 149 GLU A CG 1 ATOM 1211 C CD . GLU A 1 149 ? -13.898 71.933 16.995 1.00 28.84 ? 149 GLU A CD 1 ATOM 1212 O OE1 . GLU A 1 149 ? -14.865 71.151 17.089 1.00 32.16 ? 149 GLU A OE1 1 ATOM 1213 O OE2 . GLU A 1 149 ? -12.762 71.564 16.631 1.00 27.16 ? 149 GLU A OE2 1 ATOM 1214 N N . ALA A 1 150 ? -17.583 76.636 18.460 1.00 30.94 ? 150 ALA A N 1 ATOM 1215 C CA . ALA A 1 150 ? -18.967 77.078 18.569 1.00 32.69 ? 150 ALA A CA 1 ATOM 1216 C C . ALA A 1 150 ? -19.474 77.761 17.305 1.00 33.57 ? 150 ALA A C 1 ATOM 1217 O O . ALA A 1 150 ? -20.660 77.688 16.992 1.00 34.76 ? 150 ALA A O 1 ATOM 1218 C CB . ALA A 1 150 ? -19.122 78.009 19.768 1.00 32.74 ? 150 ALA A CB 1 ATOM 1219 N N . GLU A 1 151 ? -18.581 78.442 16.595 1.00 34.45 ? 151 GLU A N 1 ATOM 1220 C CA . GLU A 1 151 ? -18.939 79.116 15.349 1.00 34.41 ? 151 GLU A CA 1 ATOM 1221 C C . GLU A 1 151 ? -18.001 78.576 14.267 1.00 33.31 ? 151 GLU A C 1 ATOM 1222 O O . GLU A 1 151 ? -16.824 78.332 14.527 1.00 31.57 ? 151 GLU A O 1 ATOM 1223 C CB . GLU A 1 151 ? -18.757 80.634 15.466 1.00 37.10 ? 151 GLU A CB 1 ATOM 1224 C CG . GLU A 1 151 ? -19.647 81.346 16.486 1.00 42.84 ? 151 GLU A CG 1 ATOM 1225 C CD . GLU A 1 151 ? -21.140 81.178 16.216 1.00 46.77 ? 151 GLU A CD 1 ATOM 1226 O OE1 . GLU A 1 151 ? -21.537 81.049 15.038 1.00 48.84 ? 151 GLU A OE1 1 ATOM 1227 O OE2 . GLU A 1 151 ? -21.924 81.188 17.188 1.00 49.16 ? 151 GLU A OE2 1 ATOM 1228 N N . PRO A 1 152 ? -18.511 78.390 13.040 1.00 31.76 ? 152 PRO A N 1 ATOM 1229 C CA . PRO A 1 152 ? -17.719 77.876 11.919 1.00 32.89 ? 152 PRO A CA 1 ATOM 1230 C C . PRO A 1 152 ? -16.370 78.552 11.705 1.00 31.43 ? 152 PRO A C 1 ATOM 1231 O O . PRO A 1 152 ? -15.396 77.888 11.360 1.00 32.21 ? 152 PRO A O 1 ATOM 1232 C CB . PRO A 1 152 ? -18.647 78.073 10.724 1.00 31.38 ? 152 PRO A CB 1 ATOM 1233 C CG . PRO A 1 152 ? -19.991 77.868 11.321 1.00 32.01 ? 152 PRO A CG 1 ATOM 1234 C CD . PRO A 1 152 ? -19.900 78.647 12.619 1.00 32.09 ? 152 PRO A CD 1 ATOM 1235 N N . VAL A 1 153 ? -16.305 79.865 11.905 1.00 30.23 ? 153 VAL A N 1 ATOM 1236 C CA . VAL A 1 153 ? -15.045 80.574 11.696 1.00 31.84 ? 153 VAL A CA 1 ATOM 1237 C C . VAL A 1 153 ? -13.915 80.251 12.656 1.00 30.53 ? 153 VAL A C 1 ATOM 1238 O O . VAL A 1 153 ? -12.755 80.434 12.305 1.00 31.13 ? 153 VAL A O 1 ATOM 1239 C CB . VAL A 1 153 ? -15.212 82.101 11.737 1.00 33.11 ? 153 VAL A CB 1 ATOM 1240 C CG1 . VAL A 1 153 ? -16.043 82.540 10.580 1.00 40.43 ? 153 VAL A CG1 1 ATOM 1241 C CG2 . VAL A 1 153 ? -15.837 82.535 13.050 1.00 31.64 ? 153 VAL A CG2 1 ATOM 1242 N N . TYR A 1 154 ? -14.236 79.784 13.858 1.00 28.46 ? 154 TYR A N 1 ATOM 1243 C CA . TYR A 1 154 ? -13.182 79.494 14.819 1.00 28.79 ? 154 TYR A CA 1 ATOM 1244 C C . TYR A 1 154 ? -12.123 78.543 14.272 1.00 27.56 ? 154 TYR A C 1 ATOM 1245 O O . TYR A 1 154 ? -10.934 78.833 14.374 1.00 28.75 ? 154 TYR A O 1 ATOM 1246 C CB . TYR A 1 154 ? -13.767 78.949 16.125 1.00 28.97 ? 154 TYR A CB 1 ATOM 1247 C CG . TYR A 1 154 ? -14.669 79.924 16.862 1.00 30.56 ? 154 TYR A CG 1 ATOM 1248 C CD1 . TYR A 1 154 ? -14.724 81.278 16.505 1.00 32.98 ? 154 TYR A CD1 1 ATOM 1249 C CD2 . TYR A 1 154 ? -15.459 79.495 17.924 1.00 29.50 ? 154 TYR A CD2 1 ATOM 1250 C CE1 . TYR A 1 154 ? -15.553 82.177 17.194 1.00 33.03 ? 154 TYR A CE1 1 ATOM 1251 C CE2 . TYR A 1 154 ? -16.283 80.380 18.619 1.00 31.60 ? 154 TYR A CE2 1 ATOM 1252 C CZ . TYR A 1 154 ? -16.326 81.715 18.247 1.00 34.62 ? 154 TYR A CZ 1 ATOM 1253 O OH . TYR A 1 154 ? -17.157 82.577 18.928 1.00 37.75 ? 154 TYR A OH 1 ATOM 1254 N N . VAL A 1 155 ? -12.532 77.418 13.686 1.00 27.21 ? 155 VAL A N 1 ATOM 1255 C CA . VAL A 1 155 ? -11.536 76.493 13.152 1.00 27.04 ? 155 VAL A CA 1 ATOM 1256 C C . VAL A 1 155 ? -10.841 77.081 11.937 1.00 26.78 ? 155 VAL A C 1 ATOM 1257 O O . VAL A 1 155 ? -9.686 76.755 11.662 1.00 24.81 ? 155 VAL A O 1 ATOM 1258 C CB . VAL A 1 155 ? -12.139 75.112 12.792 1.00 29.22 ? 155 VAL A CB 1 ATOM 1259 C CG1 . VAL A 1 155 ? -12.628 74.420 14.077 1.00 30.73 ? 155 VAL A CG1 1 ATOM 1260 C CG2 . VAL A 1 155 ? -13.286 75.265 11.788 1.00 32.90 ? 155 VAL A CG2 1 ATOM 1261 N N . GLN A 1 156 ? -11.536 77.958 11.214 1.00 27.52 ? 156 GLN A N 1 ATOM 1262 C CA . GLN A 1 156 ? -10.945 78.596 10.040 1.00 26.40 ? 156 GLN A CA 1 ATOM 1263 C C . GLN A 1 156 ? -9.825 79.525 10.511 1.00 26.05 ? 156 GLN A C 1 ATOM 1264 O O . GLN A 1 156 ? -8.764 79.589 9.895 1.00 28.07 ? 156 GLN A O 1 ATOM 1265 C CB . GLN A 1 156 ? -12.008 79.386 9.256 1.00 28.03 ? 156 GLN A CB 1 ATOM 1266 C CG . GLN A 1 156 ? -13.128 78.518 8.657 1.00 31.19 ? 156 GLN A CG 1 ATOM 1267 C CD . GLN A 1 156 ? -14.225 79.340 7.958 1.00 35.60 ? 156 GLN A CD 1 ATOM 1268 O OE1 . GLN A 1 156 ? -14.544 80.456 8.375 1.00 36.83 ? 156 GLN A OE1 1 ATOM 1269 N NE2 . GLN A 1 156 ? -14.818 78.772 6.911 1.00 34.12 ? 156 GLN A NE2 1 ATOM 1270 N N . ARG A 1 157 ? -10.072 80.247 11.602 1.00 25.44 ? 157 ARG A N 1 ATOM 1271 C CA . ARG A 1 157 ? -9.072 81.152 12.171 1.00 27.58 ? 157 ARG A CA 1 ATOM 1272 C C . ARG A 1 157 ? -7.851 80.372 12.672 1.00 26.54 ? 157 ARG A C 1 ATOM 1273 O O . ARG A 1 157 ? -6.707 80.785 12.470 1.00 27.64 ? 157 ARG A O 1 ATOM 1274 C CB . ARG A 1 157 ? -9.664 81.930 13.347 1.00 29.17 ? 157 ARG A CB 1 ATOM 1275 C CG . ARG A 1 157 ? -10.602 83.059 12.972 1.00 30.12 ? 157 ARG A CG 1 ATOM 1276 C CD . ARG A 1 157 ? -11.274 83.607 14.229 1.00 33.29 ? 157 ARG A CD 1 ATOM 1277 N NE . ARG A 1 157 ? -12.082 84.793 13.965 1.00 33.17 ? 157 ARG A NE 1 ATOM 1278 C CZ . ARG A 1 157 ? -12.893 85.354 14.857 1.00 35.91 ? 157 ARG A CZ 1 ATOM 1279 N NH1 . ARG A 1 157 ? -13.008 84.830 16.071 1.00 35.70 ? 157 ARG A NH1 1 ATOM 1280 N NH2 . ARG A 1 157 ? -13.585 86.442 14.539 1.00 36.17 ? 157 ARG A NH2 1 ATOM 1281 N N . ALA A 1 158 ? -8.106 79.250 13.340 1.00 24.54 ? 158 ALA A N 1 ATOM 1282 C CA . ALA A 1 158 ? -7.032 78.416 13.874 1.00 24.19 ? 158 ALA A CA 1 ATOM 1283 C C . ALA A 1 158 ? -6.165 77.893 12.735 1.00 25.10 ? 158 ALA A C 1 ATOM 1284 O O . ALA A 1 158 ? -4.932 77.907 12.814 1.00 24.08 ? 158 ALA A O 1 ATOM 1285 C CB . ALA A 1 158 ? -7.620 77.249 14.669 1.00 21.80 ? 158 ALA A CB 1 ATOM 1286 N N . LYS A 1 159 ? -6.808 77.428 11.669 1.00 22.99 ? 159 LYS A N 1 ATOM 1287 C CA . LYS A 1 159 ? -6.061 76.925 10.533 1.00 27.12 ? 159 LYS A CA 1 ATOM 1288 C C . LYS A 1 159 ? -5.251 78.067 9.907 1.00 27.52 ? 159 LYS A C 1 ATOM 1289 O O . LYS A 1 159 ? -4.093 77.879 9.545 1.00 27.68 ? 159 LYS A O 1 ATOM 1290 C CB . LYS A 1 159 ? -7.016 76.324 9.494 1.00 28.03 ? 159 LYS A CB 1 ATOM 1291 C CG . LYS A 1 159 ? -6.345 75.810 8.219 1.00 26.17 ? 159 LYS A CG 1 ATOM 1292 C CD . LYS A 1 159 ? -7.410 75.310 7.242 1.00 28.90 ? 159 LYS A CD 1 ATOM 1293 C CE . LYS A 1 159 ? -6.832 74.901 5.896 1.00 29.85 ? 159 LYS A CE 1 ATOM 1294 N NZ . LYS A 1 159 ? -6.020 73.647 5.988 1.00 35.95 ? 159 LYS A NZ 1 ATOM 1295 N N . ALA A 1 160 ? -5.865 79.243 9.788 1.00 27.91 ? 160 ALA A N 1 ATOM 1296 C CA . ALA A 1 160 ? -5.197 80.408 9.201 1.00 28.55 ? 160 ALA A CA 1 ATOM 1297 C C . ALA A 1 160 ? -4.005 80.875 10.046 1.00 26.07 ? 160 ALA A C 1 ATOM 1298 O O . ALA A 1 160 ? -3.002 81.346 9.513 1.00 24.69 ? 160 ALA A O 1 ATOM 1299 C CB . ALA A 1 160 ? -6.204 81.564 9.024 1.00 28.48 ? 160 ALA A CB 1 ATOM 1300 N N . TYR A 1 161 ? -4.117 80.758 11.363 1.00 26.53 ? 161 TYR A N 1 ATOM 1301 C CA . TYR A 1 161 ? -3.007 81.163 12.219 1.00 26.49 ? 161 TYR A CA 1 ATOM 1302 C C . TYR A 1 161 ? -1.784 80.292 11.935 1.00 25.92 ? 161 TYR A C 1 ATOM 1303 O O . TYR A 1 161 ? -0.682 80.800 11.736 1.00 25.46 ? 161 TYR A O 1 ATOM 1304 C CB . TYR A 1 161 ? -3.360 81.038 13.700 1.00 27.55 ? 161 TYR A CB 1 ATOM 1305 C CG . TYR A 1 161 ? -2.158 81.295 14.582 1.00 30.97 ? 161 TYR A CG 1 ATOM 1306 C CD1 . TYR A 1 161 ? -1.654 82.587 14.747 1.00 32.88 ? 161 TYR A CD1 1 ATOM 1307 C CD2 . TYR A 1 161 ? -1.466 80.237 15.174 1.00 31.27 ? 161 TYR A CD2 1 ATOM 1308 C CE1 . TYR A 1 161 ? -0.485 82.817 15.476 1.00 33.95 ? 161 TYR A CE1 1 ATOM 1309 C CE2 . TYR A 1 161 ? -0.295 80.455 15.902 1.00 31.07 ? 161 TYR A CE2 1 ATOM 1310 C CZ . TYR A 1 161 ? 0.188 81.745 16.047 1.00 34.29 ? 161 TYR A CZ 1 ATOM 1311 O OH . TYR A 1 161 ? 1.350 81.960 16.753 1.00 35.77 ? 161 TYR A OH 1 ATOM 1312 N N . LEU A 1 162 ? -1.981 78.978 11.916 1.00 25.62 ? 162 LEU A N 1 ATOM 1313 C CA . LEU A 1 162 ? -0.878 78.050 11.669 1.00 25.71 ? 162 LEU A CA 1 ATOM 1314 C C . LEU A 1 162 ? -0.332 78.057 10.243 1.00 27.90 ? 162 LEU A C 1 ATOM 1315 O O . LEU A 1 162 ? 0.865 77.843 10.031 1.00 24.82 ? 162 LEU A O 1 ATOM 1316 C CB . LEU A 1 162 ? -1.299 76.614 12.006 1.00 24.38 ? 162 LEU A CB 1 ATOM 1317 C CG . LEU A 1 162 ? -1.535 76.230 13.470 1.00 24.44 ? 162 LEU A CG 1 ATOM 1318 C CD1 . LEU A 1 162 ? -1.668 74.715 13.568 1.00 25.17 ? 162 LEU A CD1 1 ATOM 1319 C CD2 . LEU A 1 162 ? -0.367 76.693 14.325 1.00 20.93 ? 162 LEU A CD2 1 ATOM 1320 N N . GLU A 1 163 ? -1.212 78.285 9.270 1.00 27.39 ? 163 GLU A N 1 ATOM 1321 C CA . GLU A 1 163 ? -0.818 78.266 7.864 1.00 29.48 ? 163 GLU A CA 1 ATOM 1322 C C . GLU A 1 163 ? -0.479 79.610 7.234 1.00 30.67 ? 163 GLU A C 1 ATOM 1323 O O . GLU A 1 163 ? 0.287 79.670 6.268 1.00 29.71 ? 163 GLU A O 1 ATOM 1324 C CB . GLU A 1 163 ? -1.917 77.592 7.033 1.00 28.52 ? 163 GLU A CB 1 ATOM 1325 C CG . GLU A 1 163 ? -1.940 76.074 7.150 1.00 30.01 ? 163 GLU A CG 1 ATOM 1326 C CD . GLU A 1 163 ? -3.144 75.450 6.463 1.00 30.72 ? 163 GLU A CD 1 ATOM 1327 O OE1 . GLU A 1 163 ? -3.717 76.088 5.558 1.00 34.61 ? 163 GLU A OE1 1 ATOM 1328 O OE2 . GLU A 1 163 ? -3.515 74.317 6.818 1.00 34.99 ? 163 GLU A OE2 1 ATOM 1329 N N . GLU A 1 164 ? -1.042 80.687 7.765 1.00 31.51 ? 164 GLU A N 1 ATOM 1330 C CA . GLU A 1 164 ? -0.783 81.992 7.184 1.00 34.66 ? 164 GLU A CA 1 ATOM 1331 C C . GLU A 1 164 ? -0.084 82.974 8.116 1.00 33.30 ? 164 GLU A C 1 ATOM 1332 O O . GLU A 1 164 ? 1.010 83.451 7.818 1.00 32.04 ? 164 GLU A O 1 ATOM 1333 C CB . GLU A 1 164 ? -2.100 82.605 6.687 1.00 36.34 ? 164 GLU A CB 1 ATOM 1334 C CG . GLU A 1 164 ? -2.928 81.658 5.821 1.00 44.06 ? 164 GLU A CG 1 ATOM 1335 C CD . GLU A 1 164 ? -4.155 82.320 5.217 1.00 48.45 ? 164 GLU A CD 1 ATOM 1336 O OE1 . GLU A 1 164 ? -4.909 82.987 5.957 1.00 52.25 ? 164 GLU A OE1 1 ATOM 1337 O OE2 . GLU A 1 164 ? -4.372 82.166 3.997 1.00 53.34 ? 164 GLU A OE2 1 ATOM 1338 N N . GLU A 1 165 ? -0.722 83.265 9.243 1.00 32.64 ? 165 GLU A N 1 ATOM 1339 C CA . GLU A 1 165 ? -0.198 84.230 10.200 1.00 34.27 ? 165 GLU A CA 1 ATOM 1340 C C . GLU A 1 165 ? 1.137 83.883 10.842 1.00 33.64 ? 165 GLU A C 1 ATOM 1341 O O . GLU A 1 165 ? 2.076 84.675 10.776 1.00 34.13 ? 165 GLU A O 1 ATOM 1342 C CB . GLU A 1 165 ? -1.237 84.480 11.289 1.00 37.52 ? 165 GLU A CB 1 ATOM 1343 C CG . GLU A 1 165 ? -2.495 85.158 10.771 1.00 44.24 ? 165 GLU A CG 1 ATOM 1344 C CD . GLU A 1 165 ? -3.632 85.130 11.770 1.00 47.10 ? 165 GLU A CD 1 ATOM 1345 O OE1 . GLU A 1 165 ? -3.385 85.395 12.966 1.00 50.68 ? 165 GLU A OE1 1 ATOM 1346 O OE2 . GLU A 1 165 ? -4.778 84.853 11.357 1.00 47.77 ? 165 GLU A OE2 1 ATOM 1347 N N . CYS A 1 166 ? 1.226 82.712 11.463 1.00 31.89 ? 166 CYS A N 1 ATOM 1348 C CA . CYS A 1 166 ? 2.463 82.323 12.124 1.00 31.63 ? 166 CYS A CA 1 ATOM 1349 C C . CYS A 1 166 ? 3.649 82.354 11.149 1.00 30.96 ? 166 CYS A C 1 ATOM 1350 O O . CYS A 1 166 ? 4.651 83.010 11.421 1.00 31.31 ? 166 CYS A O 1 ATOM 1351 C CB . CYS A 1 166 ? 2.315 80.946 12.773 1.00 29.79 ? 166 CYS A CB 1 ATOM 1352 S SG . CYS A 1 166 ? 3.608 80.583 14.001 1.00 34.12 ? 166 CYS A SG 1 ATOM 1353 N N . PRO A 1 167 ? 3.555 81.655 10.004 1.00 31.89 ? 167 PRO A N 1 ATOM 1354 C CA . PRO A 1 167 ? 4.697 81.706 9.082 1.00 32.73 ? 167 PRO A CA 1 ATOM 1355 C C . PRO A 1 167 ? 5.030 83.118 8.572 1.00 33.52 ? 167 PRO A C 1 ATOM 1356 O O . PRO A 1 167 ? 6.186 83.409 8.270 1.00 32.34 ? 167 PRO A O 1 ATOM 1357 C CB . PRO A 1 167 ? 4.294 80.742 7.958 1.00 33.64 ? 167 PRO A CB 1 ATOM 1358 C CG . PRO A 1 167 ? 2.811 80.638 8.077 1.00 34.72 ? 167 PRO A CG 1 ATOM 1359 C CD . PRO A 1 167 ? 2.562 80.667 9.550 1.00 31.19 ? 167 PRO A CD 1 ATOM 1360 N N . ALA A 1 168 ? 4.031 83.996 8.491 1.00 32.91 ? 168 ALA A N 1 ATOM 1361 C CA . ALA A 1 168 ? 4.276 85.365 8.039 1.00 33.50 ? 168 ALA A CA 1 ATOM 1362 C C . ALA A 1 168 ? 5.049 86.104 9.131 1.00 34.24 ? 168 ALA A C 1 ATOM 1363 O O . ALA A 1 168 ? 5.918 86.935 8.852 1.00 33.40 ? 168 ALA A O 1 ATOM 1364 C CB . ALA A 1 168 ? 2.954 86.079 7.754 1.00 33.80 ? 168 ALA A CB 1 ATOM 1365 N N . THR A 1 169 ? 4.723 85.803 10.383 1.00 32.71 ? 169 THR A N 1 ATOM 1366 C CA . THR A 1 169 ? 5.408 86.432 11.496 1.00 31.71 ? 169 THR A CA 1 ATOM 1367 C C . THR A 1 169 ? 6.849 85.934 11.516 1.00 31.15 ? 169 THR A C 1 ATOM 1368 O O . THR A 1 169 ? 7.775 86.707 11.760 1.00 33.07 ? 169 THR A O 1 ATOM 1369 C CB . THR A 1 169 ? 4.713 86.108 12.833 1.00 31.76 ? 169 THR A CB 1 ATOM 1370 O OG1 . THR A 1 169 ? 3.398 86.678 12.828 1.00 28.91 ? 169 THR A OG1 1 ATOM 1371 C CG2 . THR A 1 169 ? 5.503 86.685 14.008 1.00 30.65 ? 169 THR A CG2 1 ATOM 1372 N N . LEU A 1 170 ? 7.042 84.648 11.243 1.00 30.66 ? 170 LEU A N 1 ATOM 1373 C CA . LEU A 1 170 ? 8.387 84.084 11.221 1.00 32.03 ? 170 LEU A CA 1 ATOM 1374 C C . LEU A 1 170 ? 9.227 84.714 10.107 1.00 34.23 ? 170 LEU A C 1 ATOM 1375 O O . LEU A 1 170 ? 10.378 85.090 10.333 1.00 34.52 ? 170 LEU A O 1 ATOM 1376 C CB . LEU A 1 170 ? 8.331 82.566 11.028 1.00 29.19 ? 170 LEU A CB 1 ATOM 1377 C CG . LEU A 1 170 ? 9.652 81.834 10.737 1.00 30.57 ? 170 LEU A CG 1 ATOM 1378 C CD1 . LEU A 1 170 ? 10.695 82.130 11.809 1.00 28.17 ? 170 LEU A CD1 1 ATOM 1379 C CD2 . LEU A 1 170 ? 9.379 80.342 10.658 1.00 29.16 ? 170 LEU A CD2 1 ATOM 1380 N N . ARG A 1 171 ? 8.658 84.820 8.907 1.00 35.37 ? 171 ARG A N 1 ATOM 1381 C CA . ARG A 1 171 ? 9.381 85.416 7.786 1.00 36.49 ? 171 ARG A CA 1 ATOM 1382 C C . ARG A 1 171 ? 9.754 86.854 8.118 1.00 36.65 ? 171 ARG A C 1 ATOM 1383 O O . ARG A 1 171 ? 10.859 87.301 7.824 1.00 39.18 ? 171 ARG A O 1 ATOM 1384 C CB . ARG A 1 171 ? 8.539 85.379 6.507 1.00 36.68 ? 171 ARG A CB 1 ATOM 1385 C CG . ARG A 1 171 ? 8.443 84.008 5.856 1.00 37.77 ? 171 ARG A CG 1 ATOM 1386 C CD . ARG A 1 171 ? 7.688 84.087 4.539 1.00 39.85 ? 171 ARG A CD 1 ATOM 1387 N NE . ARG A 1 171 ? 7.222 82.777 4.084 1.00 43.62 ? 171 ARG A NE 1 ATOM 1388 C CZ . ARG A 1 171 ? 7.983 81.876 3.473 1.00 43.88 ? 171 ARG A CZ 1 ATOM 1389 N NH1 . ARG A 1 171 ? 9.266 82.131 3.232 1.00 46.81 ? 171 ARG A NH1 1 ATOM 1390 N NH2 . ARG A 1 171 ? 7.458 80.720 3.096 1.00 41.23 ? 171 ARG A NH2 1 ATOM 1391 N N . LYS A 1 172 ? 8.833 87.575 8.743 1.00 35.51 ? 172 LYS A N 1 ATOM 1392 C CA . LYS A 1 172 ? 9.098 88.954 9.119 1.00 36.66 ? 172 LYS A CA 1 ATOM 1393 C C . LYS A 1 172 ? 10.263 89.014 10.114 1.00 39.34 ? 172 LYS A C 1 ATOM 1394 O O . LYS A 1 172 ? 11.236 89.747 9.905 1.00 39.93 ? 172 LYS A O 1 ATOM 1395 C CB . LYS A 1 172 ? 7.848 89.576 9.737 1.00 36.62 ? 172 LYS A CB 1 ATOM 1396 C CG . LYS A 1 172 ? 8.026 91.013 10.160 1.00 40.30 ? 172 LYS A CG 1 ATOM 1397 C CD . LYS A 1 172 ? 6.785 91.522 10.863 1.00 45.41 ? 172 LYS A CD 1 ATOM 1398 C CE . LYS A 1 172 ? 7.004 92.914 11.426 1.00 48.58 ? 172 LYS A CE 1 ATOM 1399 N NZ . LYS A 1 172 ? 5.833 93.365 12.223 1.00 49.86 ? 172 LYS A NZ 1 ATOM 1400 N N . TYR A 1 173 ? 10.165 88.244 11.195 1.00 37.52 ? 173 TYR A N 1 ATOM 1401 C CA . TYR A 1 173 ? 11.222 88.215 12.198 1.00 36.99 ? 173 TYR A CA 1 ATOM 1402 C C . TYR A 1 173 ? 12.553 87.832 11.565 1.00 38.17 ? 173 TYR A C 1 ATOM 1403 O O . TYR A 1 173 ? 13.606 88.316 11.979 1.00 38.17 ? 173 TYR A O 1 ATOM 1404 C CB . TYR A 1 173 ? 10.890 87.218 13.316 1.00 34.07 ? 173 TYR A CB 1 ATOM 1405 C CG . TYR A 1 173 ? 9.782 87.657 14.252 1.00 33.52 ? 173 TYR A CG 1 ATOM 1406 C CD1 . TYR A 1 173 ? 9.186 88.911 14.127 1.00 30.87 ? 173 TYR A CD1 1 ATOM 1407 C CD2 . TYR A 1 173 ? 9.348 86.824 15.286 1.00 32.35 ? 173 TYR A CD2 1 ATOM 1408 C CE1 . TYR A 1 173 ? 8.193 89.328 15.008 1.00 31.43 ? 173 TYR A CE1 1 ATOM 1409 C CE2 . TYR A 1 173 ? 8.352 87.232 16.173 1.00 31.18 ? 173 TYR A CE2 1 ATOM 1410 C CZ . TYR A 1 173 ? 7.782 88.484 16.030 1.00 31.36 ? 173 TYR A CZ 1 ATOM 1411 O OH . TYR A 1 173 ? 6.807 88.897 16.911 1.00 30.21 ? 173 TYR A OH 1 ATOM 1412 N N . LEU A 1 174 ? 12.512 86.960 10.565 1.00 39.92 ? 174 LEU A N 1 ATOM 1413 C CA . LEU A 1 174 ? 13.742 86.541 9.901 1.00 43.77 ? 174 LEU A CA 1 ATOM 1414 C C . LEU A 1 174 ? 14.420 87.693 9.165 1.00 45.27 ? 174 LEU A C 1 ATOM 1415 O O . LEU A 1 174 ? 15.639 87.697 9.002 1.00 46.18 ? 174 LEU A O 1 ATOM 1416 C CB . LEU A 1 174 ? 13.469 85.400 8.919 1.00 44.03 ? 174 LEU A CB 1 ATOM 1417 C CG . LEU A 1 174 ? 13.201 84.021 9.531 1.00 47.13 ? 174 LEU A CG 1 ATOM 1418 C CD1 . LEU A 1 174 ? 13.054 82.994 8.421 1.00 47.19 ? 174 LEU A CD1 1 ATOM 1419 C CD2 . LEU A 1 174 ? 14.345 83.628 10.458 1.00 46.92 ? 174 LEU A CD2 1 ATOM 1420 N N . LYS A 1 175 ? 13.633 88.669 8.724 1.00 46.04 ? 175 LYS A N 1 ATOM 1421 C CA . LYS A 1 175 ? 14.189 89.813 8.008 1.00 48.74 ? 175 LYS A CA 1 ATOM 1422 C C . LYS A 1 175 ? 14.997 90.718 8.930 1.00 48.53 ? 175 LYS A C 1 ATOM 1423 O O . LYS A 1 175 ? 15.895 91.433 8.480 1.00 49.05 ? 175 LYS A O 1 ATOM 1424 C CB . LYS A 1 175 ? 13.074 90.627 7.348 1.00 49.34 ? 175 LYS A CB 1 ATOM 1425 C CG . LYS A 1 175 ? 12.522 90.011 6.080 1.00 52.51 ? 175 LYS A CG 1 ATOM 1426 C CD . LYS A 1 175 ? 11.518 90.944 5.419 1.00 55.37 ? 175 LYS A CD 1 ATOM 1427 C CE . LYS A 1 175 ? 11.010 90.374 4.103 1.00 57.63 ? 175 LYS A CE 1 ATOM 1428 N NZ . LYS A 1 175 ? 10.016 91.280 3.452 1.00 58.99 ? 175 LYS A NZ 1 ATOM 1429 N N . TYR A 1 176 ? 14.672 90.685 10.217 1.00 47.90 ? 176 TYR A N 1 ATOM 1430 C CA . TYR A 1 176 ? 15.363 91.506 11.208 1.00 47.57 ? 176 TYR A CA 1 ATOM 1431 C C . TYR A 1 176 ? 16.315 90.680 12.062 1.00 46.30 ? 176 TYR A C 1 ATOM 1432 O O . TYR A 1 176 ? 17.013 91.230 12.910 1.00 46.93 ? 176 TYR A O 1 ATOM 1433 C CB . TYR A 1 176 ? 14.360 92.175 12.151 1.00 49.00 ? 176 TYR A CB 1 ATOM 1434 C CG . TYR A 1 176 ? 13.411 93.161 11.511 1.00 52.19 ? 176 TYR A CG 1 ATOM 1435 C CD1 . TYR A 1 176 ? 12.456 92.746 10.581 1.00 53.06 ? 176 TYR A CD1 1 ATOM 1436 C CD2 . TYR A 1 176 ? 13.449 94.513 11.857 1.00 52.41 ? 176 TYR A CD2 1 ATOM 1437 C CE1 . TYR A 1 176 ? 11.560 93.656 10.015 1.00 52.28 ? 176 TYR A CE1 1 ATOM 1438 C CE2 . TYR A 1 176 ? 12.561 95.427 11.297 1.00 52.70 ? 176 TYR A CE2 1 ATOM 1439 C CZ . TYR A 1 176 ? 11.621 94.993 10.379 1.00 52.57 ? 176 TYR A CZ 1 ATOM 1440 O OH . TYR A 1 176 ? 10.744 95.898 9.830 1.00 52.20 ? 176 TYR A OH 1 ATOM 1441 N N . SER A 1 177 ? 16.346 89.370 11.840 1.00 44.60 ? 177 SER A N 1 ATOM 1442 C CA . SER A 1 177 ? 17.182 88.486 12.641 1.00 44.45 ? 177 SER A CA 1 ATOM 1443 C C . SER A 1 177 ? 18.353 87.850 11.908 1.00 46.48 ? 177 SER A C 1 ATOM 1444 O O . SER A 1 177 ? 19.012 86.957 12.449 1.00 46.48 ? 177 SER A O 1 ATOM 1445 C CB . SER A 1 177 ? 16.318 87.381 13.258 1.00 44.06 ? 177 SER A CB 1 ATOM 1446 O OG . SER A 1 177 ? 15.285 87.927 14.062 1.00 38.36 ? 177 SER A OG 1 ATOM 1447 N N . LYS A 1 178 ? 18.613 88.306 10.686 1.00 46.76 ? 178 LYS A N 1 ATOM 1448 C CA . LYS A 1 178 ? 19.715 87.776 9.891 1.00 48.16 ? 178 LYS A CA 1 ATOM 1449 C C . LYS A 1 178 ? 21.047 87.800 10.637 1.00 47.36 ? 178 LYS A C 1 ATOM 1450 O O . LYS A 1 178 ? 21.759 86.801 10.665 1.00 48.26 ? 178 LYS A O 1 ATOM 1451 C CB . LYS A 1 178 ? 19.859 88.562 8.584 1.00 49.89 ? 178 LYS A CB 1 ATOM 1452 C CG . LYS A 1 178 ? 18.848 88.206 7.495 1.00 52.50 ? 178 LYS A CG 1 ATOM 1453 C CD . LYS A 1 178 ? 19.068 89.082 6.260 1.00 55.08 ? 178 LYS A CD 1 ATOM 1454 C CE . LYS A 1 178 ? 18.160 88.696 5.095 1.00 56.82 ? 178 LYS A CE 1 ATOM 1455 N NZ . LYS A 1 178 ? 18.553 87.405 4.458 1.00 58.68 ? 178 LYS A NZ 1 ATOM 1456 N N . ASN A 1 179 ? 21.386 88.939 11.232 1.00 46.80 ? 179 ASN A N 1 ATOM 1457 C CA . ASN A 1 179 ? 22.647 89.062 11.962 1.00 47.89 ? 179 ASN A CA 1 ATOM 1458 C C . ASN A 1 179 ? 22.624 88.322 13.293 1.00 47.09 ? 179 ASN A C 1 ATOM 1459 O O . ASN A 1 179 ? 23.552 88.449 14.098 1.00 46.82 ? 179 ASN A O 1 ATOM 1460 C CB . ASN A 1 179 ? 22.981 90.534 12.225 1.00 50.46 ? 179 ASN A CB 1 ATOM 1461 C CG . ASN A 1 179 ? 23.184 91.324 10.948 1.00 54.67 ? 179 ASN A CG 1 ATOM 1462 O OD1 . ASN A 1 179 ? 24.021 90.977 10.114 1.00 56.24 ? 179 ASN A OD1 1 ATOM 1463 N ND2 . ASN A 1 179 ? 22.418 92.398 10.789 1.00 56.46 ? 179 ASN A ND2 1 ATOM 1464 N N . ILE A 1 180 ? 21.559 87.563 13.532 1.00 43.89 ? 180 ILE A N 1 ATOM 1465 C CA . ILE A 1 180 ? 21.441 86.816 14.775 1.00 39.35 ? 180 ILE A CA 1 ATOM 1466 C C . ILE A 1 180 ? 21.392 85.314 14.539 1.00 37.86 ? 180 ILE A C 1 ATOM 1467 O O . ILE A 1 180 ? 22.214 84.570 15.064 1.00 37.61 ? 180 ILE A O 1 ATOM 1468 C CB . ILE A 1 180 ? 20.186 87.239 15.560 1.00 37.97 ? 180 ILE A CB 1 ATOM 1469 C CG1 . ILE A 1 180 ? 20.305 88.713 15.965 1.00 35.61 ? 180 ILE A CG1 1 ATOM 1470 C CG2 . ILE A 1 180 ? 20.019 86.358 16.792 1.00 38.37 ? 180 ILE A CG2 1 ATOM 1471 C CD1 . ILE A 1 180 ? 19.130 89.235 16.767 1.00 32.89 ? 180 ILE A CD1 1 ATOM 1472 N N . LEU A 1 181 ? 20.445 84.873 13.722 1.00 36.66 ? 181 LEU A N 1 ATOM 1473 C CA . LEU A 1 181 ? 20.281 83.452 13.453 1.00 35.30 ? 181 LEU A CA 1 ATOM 1474 C C . LEU A 1 181 ? 21.239 82.879 12.420 1.00 36.70 ? 181 LEU A C 1 ATOM 1475 O O . LEU A 1 181 ? 21.555 81.692 12.465 1.00 34.03 ? 181 LEU A O 1 ATOM 1476 C CB . LEU A 1 181 ? 18.841 83.181 13.022 1.00 35.31 ? 181 LEU A CB 1 ATOM 1477 C CG . LEU A 1 181 ? 17.788 83.661 14.024 1.00 35.08 ? 181 LEU A CG 1 ATOM 1478 C CD1 . LEU A 1 181 ? 16.404 83.559 13.408 1.00 34.91 ? 181 LEU A CD1 1 ATOM 1479 C CD2 . LEU A 1 181 ? 17.888 82.832 15.301 1.00 34.85 ? 181 LEU A CD2 1 ATOM 1480 N N . ASP A 1 182 ? 21.710 83.713 11.497 1.00 38.59 ? 182 ASP A N 1 ATOM 1481 C CA . ASP A 1 182 ? 22.612 83.233 10.458 1.00 41.06 ? 182 ASP A CA 1 ATOM 1482 C C . ASP A 1 182 ? 24.089 83.471 10.738 1.00 41.03 ? 182 ASP A C 1 ATOM 1483 O O . ASP A 1 182 ? 24.935 83.178 9.898 1.00 42.21 ? 182 ASP A O 1 ATOM 1484 C CB . ASP A 1 182 ? 22.241 83.850 9.108 1.00 43.60 ? 182 ASP A CB 1 ATOM 1485 C CG . ASP A 1 182 ? 20.813 83.551 8.709 1.00 47.56 ? 182 ASP A CG 1 ATOM 1486 O OD1 . ASP A 1 182 ? 20.312 82.461 9.074 1.00 48.32 ? 182 ASP A OD1 1 ATOM 1487 O OD2 . ASP A 1 182 ? 20.196 84.398 8.022 1.00 49.45 ? 182 ASP A OD2 1 ATOM 1488 N N . ARG A 1 183 ? 24.400 83.994 11.916 1.00 41.22 ? 183 ARG A N 1 ATOM 1489 C CA . ARG A 1 183 ? 25.786 84.248 12.281 1.00 40.32 ? 183 ARG A CA 1 ATOM 1490 C C . ARG A 1 183 ? 26.630 82.992 12.228 1.00 40.60 ? 183 ARG A C 1 ATOM 1491 O O . ARG A 1 183 ? 26.138 81.879 12.418 1.00 40.96 ? 183 ARG A O 1 ATOM 1492 C CB . ARG A 1 183 ? 25.888 84.785 13.708 1.00 38.89 ? 183 ARG A CB 1 ATOM 1493 C CG . ARG A 1 183 ? 25.262 86.120 13.941 1.00 39.92 ? 183 ARG A CG 1 ATOM 1494 C CD . ARG A 1 183 ? 24.582 86.114 15.294 1.00 42.09 ? 183 ARG A CD 1 ATOM 1495 N NE . ARG A 1 183 ? 25.501 85.821 16.381 1.00 43.47 ? 183 ARG A NE 1 ATOM 1496 C CZ . ARG A 1 183 ? 25.159 85.177 17.493 1.00 40.96 ? 183 ARG A CZ 1 ATOM 1497 N NH1 . ARG A 1 183 ? 23.914 84.742 17.668 1.00 37.88 ? 183 ARG A NH1 1 ATOM 1498 N NH2 . ARG A 1 183 ? 26.064 84.983 18.437 1.00 36.83 ? 183 ARG A NH2 1 ATOM 1499 N N . GLN A 1 184 ? 27.916 83.204 11.982 1.00 40.86 ? 184 GLN A N 1 ATOM 1500 C CA . GLN A 1 184 ? 28.926 82.157 11.965 1.00 40.12 ? 184 GLN A CA 1 ATOM 1501 C C . GLN A 1 184 ? 30.067 82.779 12.762 1.00 40.25 ? 184 GLN A C 1 ATOM 1502 O O . GLN A 1 184 ? 31.093 83.157 12.204 1.00 41.41 ? 184 GLN A O 1 ATOM 1503 C CB . GLN A 1 184 ? 29.375 81.838 10.538 1.00 40.37 ? 184 GLN A CB 1 ATOM 1504 C CG . GLN A 1 184 ? 28.424 80.918 9.790 1.00 40.32 ? 184 GLN A CG 1 ATOM 1505 C CD . GLN A 1 184 ? 28.306 79.546 10.436 1.00 41.12 ? 184 GLN A CD 1 ATOM 1506 O OE1 . GLN A 1 184 ? 27.330 78.826 10.219 1.00 42.47 ? 184 GLN A OE1 1 ATOM 1507 N NE2 . GLN A 1 184 ? 29.305 79.174 11.224 1.00 39.76 ? 184 GLN A NE2 1 ATOM 1508 N N . ASP A 1 185 ? 29.854 82.914 14.069 1.00 38.53 ? 185 ASP A N 1 ATOM 1509 C CA . ASP A 1 185 ? 30.836 83.506 14.969 1.00 37.84 ? 185 ASP A CA 1 ATOM 1510 C C . ASP A 1 185 ? 31.916 82.512 15.369 1.00 39.02 ? 185 ASP A C 1 ATOM 1511 O O . ASP A 1 185 ? 31.651 81.540 16.082 1.00 38.86 ? 185 ASP A O 1 ATOM 1512 C CB . ASP A 1 185 ? 30.160 84.038 16.238 1.00 36.72 ? 185 ASP A CB 1 ATOM 1513 C CG . ASP A 1 185 ? 29.272 85.243 15.975 1.00 39.38 ? 185 ASP A CG 1 ATOM 1514 O OD1 . ASP A 1 185 ? 29.392 85.856 14.896 1.00 39.73 ? 185 ASP A OD1 1 ATOM 1515 O OD2 . ASP A 1 185 ? 28.458 85.588 16.858 1.00 42.25 ? 185 ASP A OD2 1 ATOM 1516 N N . PRO A 1 186 ? 33.159 82.752 14.928 1.00 38.33 ? 186 PRO A N 1 ATOM 1517 C CA . PRO A 1 186 ? 34.263 81.853 15.260 1.00 38.22 ? 186 PRO A CA 1 ATOM 1518 C C . PRO A 1 186 ? 34.556 81.837 16.759 1.00 38.01 ? 186 PRO A C 1 ATOM 1519 O O . PRO A 1 186 ? 34.408 82.842 17.454 1.00 38.78 ? 186 PRO A O 1 ATOM 1520 C CB . PRO A 1 186 ? 35.417 82.406 14.426 1.00 39.10 ? 186 PRO A CB 1 ATOM 1521 C CG . PRO A 1 186 ? 35.110 83.875 14.371 1.00 39.29 ? 186 PRO A CG 1 ATOM 1522 C CD . PRO A 1 186 ? 33.627 83.880 14.102 1.00 38.39 ? 186 PRO A CD 1 ATOM 1523 N N . PRO A 1 187 ? 34.970 80.682 17.280 1.00 36.83 ? 187 PRO A N 1 ATOM 1524 C CA . PRO A 1 187 ? 35.263 80.590 18.708 1.00 36.86 ? 187 PRO A CA 1 ATOM 1525 C C . PRO A 1 187 ? 36.639 81.093 19.112 1.00 36.65 ? 187 PRO A C 1 ATOM 1526 O O . PRO A 1 187 ? 37.605 80.976 18.357 1.00 36.00 ? 187 PRO A O 1 ATOM 1527 C CB . PRO A 1 187 ? 35.125 79.102 18.979 1.00 36.26 ? 187 PRO A CB 1 ATOM 1528 C CG . PRO A 1 187 ? 35.698 78.515 17.719 1.00 36.68 ? 187 PRO A CG 1 ATOM 1529 C CD . PRO A 1 187 ? 35.042 79.356 16.642 1.00 34.85 ? 187 PRO A CD 1 ATOM 1530 N N . SER A 1 188 ? 36.703 81.670 20.305 1.00 36.61 ? 188 SER A N 1 ATOM 1531 C CA . SER A 1 188 ? 37.956 82.117 20.875 1.00 38.34 ? 188 SER A CA 1 ATOM 1532 C C . SER A 1 188 ? 38.294 80.924 21.754 1.00 40.92 ? 188 SER A C 1 ATOM 1533 O O . SER A 1 188 ? 37.393 80.279 22.295 1.00 38.65 ? 188 SER A O 1 ATOM 1534 C CB . SER A 1 188 ? 37.761 83.356 21.748 1.00 38.52 ? 188 SER A CB 1 ATOM 1535 O OG . SER A 1 188 ? 37.438 84.487 20.967 1.00 40.56 ? 188 SER A OG 1 ATOM 1536 N N . VAL A 1 189 ? 39.576 80.617 21.891 1.00 42.62 ? 189 VAL A N 1 ATOM 1537 C CA . VAL A 1 189 ? 39.980 79.486 22.705 1.00 46.16 ? 189 VAL A CA 1 ATOM 1538 C C . VAL A 1 189 ? 40.992 79.902 23.764 1.00 48.43 ? 189 VAL A C 1 ATOM 1539 O O . VAL A 1 189 ? 41.792 80.812 23.551 1.00 48.32 ? 189 VAL A O 1 ATOM 1540 C CB . VAL A 1 189 ? 40.616 78.387 21.838 1.00 47.80 ? 189 VAL A CB 1 ATOM 1541 C CG1 . VAL A 1 189 ? 39.717 78.066 20.660 1.00 47.28 ? 189 VAL A CG1 1 ATOM 1542 C CG2 . VAL A 1 189 ? 41.972 78.843 21.353 1.00 51.03 ? 189 VAL A CG2 1 ATOM 1543 N N . VAL A 1 190 ? 40.950 79.230 24.908 1.00 49.78 ? 190 VAL A N 1 ATOM 1544 C CA . VAL A 1 190 ? 41.879 79.506 25.992 1.00 51.08 ? 190 VAL A CA 1 ATOM 1545 C C . VAL A 1 190 ? 42.187 78.204 26.717 1.00 52.65 ? 190 VAL A C 1 ATOM 1546 O O . VAL A 1 190 ? 41.291 77.549 27.250 1.00 52.31 ? 190 VAL A O 1 ATOM 1547 C CB . VAL A 1 190 ? 41.296 80.513 27.005 1.00 52.39 ? 190 VAL A CB 1 ATOM 1548 C CG1 . VAL A 1 190 ? 42.323 80.811 28.092 1.00 51.13 ? 190 VAL A CG1 1 ATOM 1549 C CG2 . VAL A 1 190 ? 40.900 81.797 26.295 1.00 54.63 ? 190 VAL A CG2 1 ATOM 1550 N N . VAL A 1 191 ? 43.456 77.818 26.708 1.00 53.72 ? 191 VAL A N 1 ATOM 1551 C CA . VAL A 1 191 ? 43.888 76.604 27.380 1.00 54.50 ? 191 VAL A CA 1 ATOM 1552 C C . VAL A 1 191 ? 44.420 76.999 28.745 1.00 55.80 ? 191 VAL A C 1 ATOM 1553 O O . VAL A 1 191 ? 45.148 77.981 28.877 1.00 55.36 ? 191 VAL A O 1 ATOM 1554 C CB . VAL A 1 191 ? 44.996 75.885 26.593 1.00 54.24 ? 191 VAL A CB 1 ATOM 1555 C CG1 . VAL A 1 191 ? 45.586 74.768 27.434 1.00 54.94 ? 191 VAL A CG1 1 ATOM 1556 C CG2 . VAL A 1 191 ? 44.428 75.319 25.307 1.00 53.60 ? 191 VAL A CG2 1 ATOM 1557 N N . THR A 1 192 ? 44.046 76.238 29.763 1.00 57.72 ? 192 THR A N 1 ATOM 1558 C CA . THR A 1 192 ? 44.487 76.534 31.112 1.00 59.52 ? 192 THR A CA 1 ATOM 1559 C C . THR A 1 192 ? 44.711 75.242 31.886 1.00 60.67 ? 192 THR A C 1 ATOM 1560 O O . THR A 1 192 ? 44.143 74.203 31.555 1.00 60.26 ? 192 THR A O 1 ATOM 1561 C CB . THR A 1 192 ? 43.448 77.403 31.845 1.00 59.54 ? 192 THR A CB 1 ATOM 1562 O OG1 . THR A 1 192 ? 43.996 77.857 33.087 1.00 64.15 ? 192 THR A OG1 1 ATOM 1563 C CG2 . THR A 1 192 ? 42.183 76.606 32.123 1.00 59.35 ? 192 THR A CG2 1 ATOM 1564 N N . SER A 1 193 ? 45.554 75.306 32.909 1.00 62.95 ? 193 SER A N 1 ATOM 1565 C CA . SER A 1 193 ? 45.840 74.130 33.716 1.00 65.45 ? 193 SER A CA 1 ATOM 1566 C C . SER A 1 193 ? 45.662 74.464 35.183 1.00 66.96 ? 193 SER A C 1 ATOM 1567 O O . SER A 1 193 ? 45.769 75.624 35.587 1.00 66.11 ? 193 SER A O 1 ATOM 1568 C CB . SER A 1 193 ? 47.272 73.646 33.478 1.00 64.41 ? 193 SER A CB 1 ATOM 1569 O OG . SER A 1 193 ? 48.210 74.565 34.005 1.00 64.00 ? 193 SER A OG 1 ATOM 1570 N N . HIS A 1 194 ? 45.383 73.440 35.978 1.00 69.85 ? 194 HIS A N 1 ATOM 1571 C CA . HIS A 1 194 ? 45.200 73.626 37.406 1.00 73.31 ? 194 HIS A CA 1 ATOM 1572 C C . HIS A 1 194 ? 45.693 72.396 38.148 1.00 74.74 ? 194 HIS A C 1 ATOM 1573 O O . HIS A 1 194 ? 45.472 71.264 37.713 1.00 73.40 ? 194 HIS A O 1 ATOM 1574 C CB . HIS A 1 194 ? 43.729 73.874 37.729 1.00 75.18 ? 194 HIS A CB 1 ATOM 1575 C CG . HIS A 1 194 ? 43.489 74.285 39.146 1.00 77.34 ? 194 HIS A CG 1 ATOM 1576 N ND1 . HIS A 1 194 ? 43.792 73.473 40.217 1.00 78.23 ? 194 HIS A ND1 1 ATOM 1577 C CD2 . HIS A 1 194 ? 42.997 75.432 39.671 1.00 78.37 ? 194 HIS A CD2 1 ATOM 1578 C CE1 . HIS A 1 194 ? 43.497 74.102 41.341 1.00 79.21 ? 194 HIS A CE1 1 ATOM 1579 N NE2 . HIS A 1 194 ? 43.014 75.293 41.037 1.00 79.43 ? 194 HIS A NE2 1 ATOM 1580 N N . GLN A 1 195 ? 46.369 72.629 39.266 1.00 77.68 ? 195 GLN A N 1 ATOM 1581 C CA . GLN A 1 195 ? 46.909 71.543 40.072 1.00 80.82 ? 195 GLN A CA 1 ATOM 1582 C C . GLN A 1 195 ? 46.216 71.485 41.424 1.00 82.12 ? 195 GLN A C 1 ATOM 1583 O O . GLN A 1 195 ? 46.259 72.443 42.197 1.00 82.12 ? 195 GLN A O 1 ATOM 1584 C CB . GLN A 1 195 ? 48.414 71.737 40.277 1.00 82.07 ? 195 GLN A CB 1 ATOM 1585 C CG . GLN A 1 195 ? 49.096 70.604 41.027 1.00 83.43 ? 195 GLN A CG 1 ATOM 1586 C CD . GLN A 1 195 ? 49.086 69.304 40.248 1.00 84.64 ? 195 GLN A CD 1 ATOM 1587 O OE1 . GLN A 1 195 ? 48.027 68.794 39.882 1.00 85.88 ? 195 GLN A OE1 1 ATOM 1588 N NE2 . GLN A 1 195 ? 50.270 68.760 39.988 1.00 84.22 ? 195 GLN A NE2 1 ATOM 1589 N N . ALA A 1 196 ? 45.568 70.359 41.702 1.00 83.86 ? 196 ALA A N 1 ATOM 1590 C CA . ALA A 1 196 ? 44.878 70.175 42.970 1.00 85.53 ? 196 ALA A CA 1 ATOM 1591 C C . ALA A 1 196 ? 45.865 69.588 43.976 1.00 86.50 ? 196 ALA A C 1 ATOM 1592 O O . ALA A 1 196 ? 46.595 68.646 43.663 1.00 86.58 ? 196 ALA A O 1 ATOM 1593 C CB . ALA A 1 196 ? 43.689 69.241 42.789 1.00 85.44 ? 196 ALA A CB 1 ATOM 1594 N N . PRO A 1 197 ? 45.905 70.143 45.197 1.00 87.34 ? 197 PRO A N 1 ATOM 1595 C CA . PRO A 1 197 ? 46.825 69.638 46.220 1.00 87.81 ? 197 PRO A CA 1 ATOM 1596 C C . PRO A 1 197 ? 46.641 68.143 46.465 1.00 87.95 ? 197 PRO A C 1 ATOM 1597 O O . PRO A 1 197 ? 45.713 67.725 47.157 1.00 88.37 ? 197 PRO A O 1 ATOM 1598 C CB . PRO A 1 197 ? 46.479 70.486 47.443 1.00 88.01 ? 197 PRO A CB 1 ATOM 1599 C CG . PRO A 1 197 ? 45.024 70.797 47.237 1.00 87.97 ? 197 PRO A CG 1 ATOM 1600 C CD . PRO A 1 197 ? 44.985 71.141 45.770 1.00 87.64 ? 197 PRO A CD 1 ATOM 1601 N N . GLY A 1 198 ? 47.529 67.342 45.885 1.00 87.75 ? 198 GLY A N 1 ATOM 1602 C CA . GLY A 1 198 ? 47.443 65.904 46.049 1.00 87.31 ? 198 GLY A CA 1 ATOM 1603 C C . GLY A 1 198 ? 46.921 65.209 44.807 1.00 87.06 ? 198 GLY A C 1 ATOM 1604 O O . GLY A 1 198 ? 47.100 64.002 44.643 1.00 87.23 ? 198 GLY A O 1 ATOM 1605 N N . GLU A 1 199 ? 46.274 65.970 43.928 1.00 86.73 ? 199 GLU A N 1 ATOM 1606 C CA . GLU A 1 199 ? 45.724 65.417 42.694 1.00 85.79 ? 199 GLU A CA 1 ATOM 1607 C C . GLU A 1 199 ? 46.591 65.771 41.489 1.00 84.64 ? 199 GLU A C 1 ATOM 1608 O O . GLU A 1 199 ? 47.421 66.678 41.553 1.00 84.34 ? 199 GLU A O 1 ATOM 1609 C CB . GLU A 1 199 ? 44.303 65.938 42.471 1.00 86.65 ? 199 GLU A CB 1 ATOM 1610 C CG . GLU A 1 199 ? 43.339 65.617 43.600 1.00 87.63 ? 199 GLU A CG 1 ATOM 1611 C CD . GLU A 1 199 ? 41.952 66.180 43.357 1.00 88.40 ? 199 GLU A CD 1 ATOM 1612 O OE1 . GLU A 1 199 ? 41.318 65.791 42.353 1.00 89.02 ? 199 GLU A OE1 1 ATOM 1613 O OE2 . GLU A 1 199 ? 41.497 67.014 44.169 1.00 88.24 ? 199 GLU A OE2 1 ATOM 1614 N N . LYS A 1 200 ? 46.387 65.049 40.390 1.00 82.98 ? 200 LYS A N 1 ATOM 1615 C CA . LYS A 1 200 ? 47.143 65.277 39.163 1.00 81.19 ? 200 LYS A CA 1 ATOM 1616 C C . LYS A 1 200 ? 46.833 66.647 38.571 1.00 80.05 ? 200 LYS A C 1 ATOM 1617 O O . LYS A 1 200 ? 45.890 67.319 38.991 1.00 80.41 ? 200 LYS A O 1 ATOM 1618 C CB . LYS A 1 200 ? 46.801 64.209 38.122 1.00 81.22 ? 200 LYS A CB 1 ATOM 1619 C CG . LYS A 1 200 ? 47.020 62.784 38.580 1.00 80.93 ? 200 LYS A CG 1 ATOM 1620 C CD . LYS A 1 200 ? 46.727 61.807 37.455 1.00 80.88 ? 200 LYS A CD 1 ATOM 1621 C CE . LYS A 1 200 ? 46.929 60.371 37.909 1.00 82.23 ? 200 LYS A CE 1 ATOM 1622 N NZ . LYS A 1 200 ? 48.317 60.124 38.400 1.00 81.66 ? 200 LYS A NZ 1 ATOM 1623 N N . LYS A 1 201 ? 47.635 67.056 37.593 1.00 78.44 ? 201 LYS A N 1 ATOM 1624 C CA . LYS A 1 201 ? 47.431 68.337 36.927 1.00 76.06 ? 201 LYS A CA 1 ATOM 1625 C C . LYS A 1 201 ? 46.334 68.145 35.886 1.00 74.03 ? 201 LYS A C 1 ATOM 1626 O O . LYS A 1 201 ? 46.272 67.109 35.220 1.00 73.56 ? 201 LYS A O 1 ATOM 1627 C CB . LYS A 1 201 ? 48.716 68.798 36.235 1.00 76.91 ? 201 LYS A CB 1 ATOM 1628 C CG . LYS A 1 201 ? 48.584 70.137 35.522 1.00 77.06 ? 201 LYS A CG 1 ATOM 1629 C CD . LYS A 1 201 ? 49.805 70.450 34.672 1.00 77.14 ? 201 LYS A CD 1 ATOM 1630 C CE . LYS A 1 201 ? 51.062 70.579 35.512 1.00 77.56 ? 201 LYS A CE 1 ATOM 1631 N NZ . LYS A 1 201 ? 52.247 70.879 34.663 1.00 78.23 ? 201 LYS A NZ 1 ATOM 1632 N N . LYS A 1 202 ? 45.470 69.142 35.742 1.00 71.24 ? 202 LYS A N 1 ATOM 1633 C CA . LYS A 1 202 ? 44.381 69.047 34.782 1.00 68.85 ? 202 LYS A CA 1 ATOM 1634 C C . LYS A 1 202 ? 44.421 70.170 33.752 1.00 66.41 ? 202 LYS A C 1 ATOM 1635 O O . LYS A 1 202 ? 44.529 71.349 34.098 1.00 65.26 ? 202 LYS A O 1 ATOM 1636 C CB . LYS A 1 202 ? 43.049 69.042 35.531 1.00 69.63 ? 202 LYS A CB 1 ATOM 1637 C CG . LYS A 1 202 ? 42.947 67.891 36.521 1.00 70.59 ? 202 LYS A CG 1 ATOM 1638 C CD . LYS A 1 202 ? 41.759 68.031 37.451 1.00 72.54 ? 202 LYS A CD 1 ATOM 1639 C CE . LYS A 1 202 ? 41.701 66.866 38.432 1.00 72.68 ? 202 LYS A CE 1 ATOM 1640 N NZ . LYS A 1 202 ? 40.605 67.032 39.425 1.00 72.64 ? 202 LYS A NZ 1 ATOM 1641 N N . LEU A 1 203 ? 44.344 69.785 32.482 1.00 63.72 ? 203 LEU A N 1 ATOM 1642 C CA . LEU A 1 203 ? 44.374 70.737 31.381 1.00 61.48 ? 203 LEU A CA 1 ATOM 1643 C C . LEU A 1 203 ? 42.964 70.984 30.866 1.00 59.71 ? 203 LEU A C 1 ATOM 1644 O O . LEU A 1 203 ? 42.273 70.055 30.450 1.00 59.16 ? 203 LEU A O 1 ATOM 1645 C CB . LEU A 1 203 ? 45.251 70.205 30.245 1.00 61.02 ? 203 LEU A CB 1 ATOM 1646 C CG . LEU A 1 203 ? 46.678 69.791 30.621 1.00 61.45 ? 203 LEU A CG 1 ATOM 1647 C CD1 . LEU A 1 203 ? 47.430 69.389 29.362 1.00 61.47 ? 203 LEU A CD1 1 ATOM 1648 C CD2 . LEU A 1 203 ? 47.389 70.937 31.330 1.00 60.59 ? 203 LEU A CD2 1 ATOM 1649 N N . LYS A 1 204 ? 42.553 72.246 30.886 1.00 57.60 ? 204 LYS A N 1 ATOM 1650 C CA . LYS A 1 204 ? 41.223 72.636 30.437 1.00 55.17 ? 204 LYS A CA 1 ATOM 1651 C C . LYS A 1 204 ? 41.250 73.490 29.177 1.00 54.08 ? 204 LYS A C 1 ATOM 1652 O O . LYS A 1 204 ? 41.909 74.532 29.132 1.00 53.30 ? 204 LYS A O 1 ATOM 1653 C CB . LYS A 1 204 ? 40.519 73.407 31.552 1.00 55.58 ? 204 LYS A CB 1 ATOM 1654 C CG . LYS A 1 204 ? 39.202 74.054 31.161 1.00 55.43 ? 204 LYS A CG 1 ATOM 1655 C CD . LYS A 1 204 ? 38.677 74.877 32.327 1.00 56.82 ? 204 LYS A CD 1 ATOM 1656 C CE . LYS A 1 204 ? 37.398 75.610 31.979 1.00 59.42 ? 204 LYS A CE 1 ATOM 1657 N NZ . LYS A 1 204 ? 36.963 76.479 33.111 1.00 60.14 ? 204 LYS A NZ 1 ATOM 1658 N N . CYS A 1 205 ? 40.530 73.039 28.157 1.00 52.00 ? 205 CYS A N 1 ATOM 1659 C CA . CYS A 1 205 ? 40.434 73.771 26.906 1.00 49.86 ? 205 CYS A CA 1 ATOM 1660 C C . CYS A 1 205 ? 39.039 74.355 26.778 1.00 48.18 ? 205 CYS A C 1 ATOM 1661 O O . CYS A 1 205 ? 38.050 73.618 26.739 1.00 47.92 ? 205 CYS A O 1 ATOM 1662 C CB . CYS A 1 205 ? 40.674 72.867 25.714 1.00 49.34 ? 205 CYS A CB 1 ATOM 1663 S SG . CYS A 1 205 ? 40.599 73.838 24.183 1.00 55.09 ? 205 CYS A SG 1 ATOM 1664 N N . LEU A 1 206 ? 38.965 75.676 26.690 1.00 45.90 ? 206 LEU A N 1 ATOM 1665 C CA . LEU A 1 206 ? 37.688 76.363 26.586 1.00 43.18 ? 206 LEU A CA 1 ATOM 1666 C C . LEU A 1 206 ? 37.490 77.128 25.282 1.00 43.18 ? 206 LEU A C 1 ATOM 1667 O O . LEU A 1 206 ? 38.307 77.976 24.921 1.00 43.30 ? 206 LEU A O 1 ATOM 1668 C CB . LEU A 1 206 ? 37.532 77.340 27.751 1.00 41.70 ? 206 LEU A CB 1 ATOM 1669 C CG . LEU A 1 206 ? 36.245 78.168 27.723 1.00 43.26 ? 206 LEU A CG 1 ATOM 1670 C CD1 . LEU A 1 206 ? 35.056 77.247 27.966 1.00 42.97 ? 206 LEU A CD1 1 ATOM 1671 C CD2 . LEU A 1 206 ? 36.294 79.260 28.776 1.00 42.17 ? 206 LEU A CD2 1 ATOM 1672 N N . ALA A 1 207 ? 36.401 76.822 24.583 1.00 41.43 ? 207 ALA A N 1 ATOM 1673 C CA . ALA A 1 207 ? 36.047 77.518 23.347 1.00 39.20 ? 207 ALA A CA 1 ATOM 1674 C C . ALA A 1 207 ? 34.825 78.349 23.723 1.00 39.33 ? 207 ALA A C 1 ATOM 1675 O O . ALA A 1 207 ? 33.863 77.809 24.266 1.00 39.07 ? 207 ALA A O 1 ATOM 1676 C CB . ALA A 1 207 ? 35.692 76.522 22.257 1.00 39.24 ? 207 ALA A CB 1 ATOM 1677 N N . TYR A 1 208 ? 34.863 79.652 23.457 1.00 37.35 ? 208 TYR A N 1 ATOM 1678 C CA . TYR A 1 208 ? 33.747 80.528 23.799 1.00 36.23 ? 208 TYR A CA 1 ATOM 1679 C C . TYR A 1 208 ? 33.417 81.561 22.729 1.00 35.59 ? 208 TYR A C 1 ATOM 1680 O O . TYR A 1 208 ? 34.151 81.724 21.756 1.00 36.16 ? 208 TYR A O 1 ATOM 1681 C CB . TYR A 1 208 ? 34.020 81.253 25.120 1.00 37.77 ? 208 TYR A CB 1 ATOM 1682 C CG . TYR A 1 208 ? 35.280 82.096 25.126 1.00 40.27 ? 208 TYR A CG 1 ATOM 1683 C CD1 . TYR A 1 208 ? 36.542 81.500 25.111 1.00 41.32 ? 208 TYR A CD1 1 ATOM 1684 C CD2 . TYR A 1 208 ? 35.209 83.491 25.138 1.00 42.00 ? 208 TYR A CD2 1 ATOM 1685 C CE1 . TYR A 1 208 ? 37.706 82.272 25.109 1.00 43.24 ? 208 TYR A CE1 1 ATOM 1686 C CE2 . TYR A 1 208 ? 36.369 84.276 25.135 1.00 42.33 ? 208 TYR A CE2 1 ATOM 1687 C CZ . TYR A 1 208 ? 37.612 83.655 25.121 1.00 44.13 ? 208 TYR A CZ 1 ATOM 1688 O OH . TYR A 1 208 ? 38.763 84.412 25.114 1.00 48.03 ? 208 TYR A OH 1 ATOM 1689 N N . ASP A 1 209 ? 32.296 82.248 22.928 1.00 35.96 ? 209 ASP A N 1 ATOM 1690 C CA . ASP A 1 209 ? 31.813 83.285 22.020 1.00 36.82 ? 209 ASP A CA 1 ATOM 1691 C C . ASP A 1 209 ? 31.499 82.785 20.612 1.00 37.56 ? 209 ASP A C 1 ATOM 1692 O O . ASP A 1 209 ? 31.589 83.548 19.650 1.00 38.38 ? 209 ASP A O 1 ATOM 1693 C CB . ASP A 1 209 ? 32.826 84.436 21.924 1.00 37.48 ? 209 ASP A CB 1 ATOM 1694 C CG . ASP A 1 209 ? 32.893 85.277 23.193 1.00 38.69 ? 209 ASP A CG 1 ATOM 1695 O OD1 . ASP A 1 209 ? 31.975 85.194 24.040 1.00 39.97 ? 209 ASP A OD1 1 ATOM 1696 O OD2 . ASP A 1 209 ? 33.862 86.046 23.334 1.00 40.45 ? 209 ASP A OD2 1 ATOM 1697 N N . PHE A 1 210 ? 31.118 81.519 20.478 1.00 35.46 ? 210 PHE A N 1 ATOM 1698 C CA . PHE A 1 210 ? 30.816 81.000 19.152 1.00 34.16 ? 210 PHE A CA 1 ATOM 1699 C C . PHE A 1 210 ? 29.337 80.713 18.893 1.00 34.54 ? 210 PHE A C 1 ATOM 1700 O O . PHE A 1 210 ? 28.527 80.612 19.822 1.00 33.43 ? 210 PHE A O 1 ATOM 1701 C CB . PHE A 1 210 ? 31.662 79.751 18.874 1.00 34.97 ? 210 PHE A CB 1 ATOM 1702 C CG . PHE A 1 210 ? 31.353 78.580 19.773 1.00 36.26 ? 210 PHE A CG 1 ATOM 1703 C CD1 . PHE A 1 210 ? 30.374 77.653 19.421 1.00 33.48 ? 210 PHE A CD1 1 ATOM 1704 C CD2 . PHE A 1 210 ? 32.067 78.385 20.954 1.00 36.31 ? 210 PHE A CD2 1 ATOM 1705 C CE1 . PHE A 1 210 ? 30.113 76.546 20.228 1.00 34.15 ? 210 PHE A CE1 1 ATOM 1706 C CE2 . PHE A 1 210 ? 31.812 77.274 21.775 1.00 36.21 ? 210 PHE A CE2 1 ATOM 1707 C CZ . PHE A 1 210 ? 30.835 76.356 21.407 1.00 32.28 ? 210 PHE A CZ 1 ATOM 1708 N N . TYR A 1 211 ? 28.997 80.609 17.612 1.00 34.09 ? 211 TYR A N 1 ATOM 1709 C CA . TYR A 1 211 ? 27.634 80.333 17.172 1.00 33.28 ? 211 TYR A CA 1 ATOM 1710 C C . TYR A 1 211 ? 27.714 79.935 15.707 1.00 34.39 ? 211 TYR A C 1 ATOM 1711 O O . TYR A 1 211 ? 28.463 80.551 14.946 1.00 35.11 ? 211 TYR A O 1 ATOM 1712 C CB . TYR A 1 211 ? 26.757 81.582 17.306 1.00 31.95 ? 211 TYR A CB 1 ATOM 1713 C CG . TYR A 1 211 ? 25.285 81.306 17.086 1.00 32.48 ? 211 TYR A CG 1 ATOM 1714 C CD1 . TYR A 1 211 ? 24.483 80.828 18.126 1.00 32.51 ? 211 TYR A CD1 1 ATOM 1715 C CD2 . TYR A 1 211 ? 24.700 81.482 15.829 1.00 30.77 ? 211 TYR A CD2 1 ATOM 1716 C CE1 . TYR A 1 211 ? 23.133 80.530 17.919 1.00 31.46 ? 211 TYR A CE1 1 ATOM 1717 C CE2 . TYR A 1 211 ? 23.355 81.186 15.610 1.00 32.42 ? 211 TYR A CE2 1 ATOM 1718 C CZ . TYR A 1 211 ? 22.578 80.709 16.664 1.00 32.90 ? 211 TYR A CZ 1 ATOM 1719 O OH . TYR A 1 211 ? 21.253 80.404 16.455 1.00 30.34 ? 211 TYR A OH 1 ATOM 1720 N N . PRO A 1 212 ? 26.949 78.905 15.283 1.00 34.56 ? 212 PRO A N 1 ATOM 1721 C CA . PRO A 1 212 ? 26.004 78.060 16.037 1.00 33.99 ? 212 PRO A CA 1 ATOM 1722 C C . PRO A 1 212 ? 26.678 77.194 17.103 1.00 33.48 ? 212 PRO A C 1 ATOM 1723 O O . PRO A 1 212 ? 27.901 77.198 17.228 1.00 32.48 ? 212 PRO A O 1 ATOM 1724 C CB . PRO A 1 212 ? 25.350 77.206 14.949 1.00 35.04 ? 212 PRO A CB 1 ATOM 1725 C CG . PRO A 1 212 ? 25.480 78.055 13.709 1.00 37.76 ? 212 PRO A CG 1 ATOM 1726 C CD . PRO A 1 212 ? 26.880 78.595 13.844 1.00 33.02 ? 212 PRO A CD 1 ATOM 1727 N N . GLY A 1 213 ? 25.868 76.435 17.844 1.00 32.97 ? 213 GLY A N 1 ATOM 1728 C CA . GLY A 1 213 ? 26.369 75.594 18.919 1.00 33.05 ? 213 GLY A CA 1 ATOM 1729 C C . GLY A 1 213 ? 27.165 74.354 18.555 1.00 35.85 ? 213 GLY A C 1 ATOM 1730 O O . GLY A 1 213 ? 28.037 73.937 19.311 1.00 37.04 ? 213 GLY A O 1 ATOM 1731 N N . LYS A 1 214 ? 26.862 73.748 17.415 1.00 36.97 ? 214 LYS A N 1 ATOM 1732 C CA . LYS A 1 214 ? 27.576 72.557 16.971 1.00 39.30 ? 214 LYS A CA 1 ATOM 1733 C C . LYS A 1 214 ? 29.084 72.840 16.969 1.00 40.90 ? 214 LYS A C 1 ATOM 1734 O O . LYS A 1 214 ? 29.536 73.808 16.357 1.00 38.80 ? 214 LYS A O 1 ATOM 1735 C CB . LYS A 1 214 ? 27.104 72.195 15.562 1.00 41.57 ? 214 LYS A CB 1 ATOM 1736 C CG . LYS A 1 214 ? 27.845 71.052 14.901 1.00 47.09 ? 214 LYS A CG 1 ATOM 1737 C CD . LYS A 1 214 ? 27.494 69.716 15.528 1.00 50.45 ? 214 LYS A CD 1 ATOM 1738 C CE . LYS A 1 214 ? 28.057 68.571 14.697 1.00 52.82 ? 214 LYS A CE 1 ATOM 1739 N NZ . LYS A 1 214 ? 27.552 68.625 13.297 1.00 54.31 ? 214 LYS A NZ 1 ATOM 1740 N N . ILE A 1 215 ? 29.863 72.001 17.648 1.00 41.74 ? 215 ILE A N 1 ATOM 1741 C CA . ILE A 1 215 ? 31.311 72.207 17.697 1.00 42.38 ? 215 ILE A CA 1 ATOM 1742 C C . ILE A 1 215 ? 32.074 70.955 18.131 1.00 44.57 ? 215 ILE A C 1 ATOM 1743 O O . ILE A 1 215 ? 31.550 70.121 18.876 1.00 42.81 ? 215 ILE A O 1 ATOM 1744 C CB . ILE A 1 215 ? 31.667 73.365 18.667 1.00 42.22 ? 215 ILE A CB 1 ATOM 1745 C CG1 . ILE A 1 215 ? 33.128 73.781 18.484 1.00 41.54 ? 215 ILE A CG1 1 ATOM 1746 C CG2 . ILE A 1 215 ? 31.427 72.933 20.112 1.00 40.21 ? 215 ILE A CG2 1 ATOM 1747 C CD1 . ILE A 1 215 ? 33.511 75.035 19.265 1.00 38.82 ? 215 ILE A CD1 1 ATOM 1748 N N . ASP A 1 216 ? 33.313 70.837 17.658 1.00 44.84 ? 216 ASP A N 1 ATOM 1749 C CA . ASP A 1 216 ? 34.177 69.706 17.990 1.00 44.76 ? 216 ASP A CA 1 ATOM 1750 C C . ASP A 1 216 ? 35.381 70.216 18.779 1.00 45.72 ? 216 ASP A C 1 ATOM 1751 O O . ASP A 1 216 ? 36.251 70.893 18.233 1.00 45.21 ? 216 ASP A O 1 ATOM 1752 C CB . ASP A 1 216 ? 34.661 69.021 16.711 1.00 47.53 ? 216 ASP A CB 1 ATOM 1753 C CG . ASP A 1 216 ? 35.431 67.735 16.985 1.00 51.24 ? 216 ASP A CG 1 ATOM 1754 O OD1 . ASP A 1 216 ? 36.269 67.716 17.913 1.00 51.27 ? 216 ASP A OD1 1 ATOM 1755 O OD2 . ASP A 1 216 ? 35.207 66.740 16.259 1.00 53.64 ? 216 ASP A OD2 1 ATOM 1756 N N . VAL A 1 217 ? 35.423 69.889 20.065 1.00 46.28 ? 217 VAL A N 1 ATOM 1757 C CA . VAL A 1 217 ? 36.514 70.310 20.936 1.00 47.82 ? 217 VAL A CA 1 ATOM 1758 C C . VAL A 1 217 ? 37.177 69.090 21.574 1.00 50.15 ? 217 VAL A C 1 ATOM 1759 O O . VAL A 1 217 ? 36.524 68.343 22.302 1.00 49.68 ? 217 VAL A O 1 ATOM 1760 C CB . VAL A 1 217 ? 35.994 71.214 22.076 1.00 47.71 ? 217 VAL A CB 1 ATOM 1761 C CG1 . VAL A 1 217 ? 37.160 71.736 22.898 1.00 47.82 ? 217 VAL A CG1 1 ATOM 1762 C CG2 . VAL A 1 217 ? 35.168 72.357 21.506 1.00 47.03 ? 217 VAL A CG2 1 ATOM 1763 N N . HIS A 1 218 ? 38.465 68.881 21.312 1.00 51.61 ? 218 HIS A N 1 ATOM 1764 C CA . HIS A 1 218 ? 39.154 67.740 21.912 1.00 53.51 ? 218 HIS A CA 1 ATOM 1765 C C . HIS A 1 218 ? 40.650 67.929 22.128 1.00 54.79 ? 218 HIS A C 1 ATOM 1766 O O . HIS A 1 218 ? 41.311 68.678 21.409 1.00 55.32 ? 218 HIS A O 1 ATOM 1767 C CB . HIS A 1 218 ? 38.928 66.468 21.086 1.00 53.73 ? 218 HIS A CB 1 ATOM 1768 C CG . HIS A 1 218 ? 39.539 66.507 19.720 1.00 55.71 ? 218 HIS A CG 1 ATOM 1769 N ND1 . HIS A 1 218 ? 38.951 67.160 18.659 1.00 56.62 ? 218 HIS A ND1 1 ATOM 1770 C CD2 . HIS A 1 218 ? 40.681 65.962 19.239 1.00 56.15 ? 218 HIS A CD2 1 ATOM 1771 C CE1 . HIS A 1 218 ? 39.702 67.013 17.582 1.00 55.63 ? 218 HIS A CE1 1 ATOM 1772 N NE2 . HIS A 1 218 ? 40.758 66.289 17.907 1.00 56.67 ? 218 HIS A NE2 1 ATOM 1773 N N . TRP A 1 219 ? 41.170 67.240 23.138 1.00 56.58 ? 219 TRP A N 1 ATOM 1774 C CA . TRP A 1 219 ? 42.587 67.290 23.469 1.00 57.86 ? 219 TRP A CA 1 ATOM 1775 C C . TRP A 1 219 ? 43.334 66.185 22.740 1.00 59.79 ? 219 TRP A C 1 ATOM 1776 O O . TRP A 1 219 ? 42.735 65.212 22.279 1.00 59.94 ? 219 TRP A O 1 ATOM 1777 C CB . TRP A 1 219 ? 42.810 67.090 24.969 1.00 55.72 ? 219 TRP A CB 1 ATOM 1778 C CG . TRP A 1 219 ? 42.685 68.316 25.802 1.00 53.80 ? 219 TRP A CG 1 ATOM 1779 C CD1 . TRP A 1 219 ? 41.646 68.651 26.619 1.00 52.50 ? 219 TRP A CD1 1 ATOM 1780 C CD2 . TRP A 1 219 ? 43.661 69.350 25.948 1.00 52.94 ? 219 TRP A CD2 1 ATOM 1781 N NE1 . TRP A 1 219 ? 41.917 69.828 27.271 1.00 52.05 ? 219 TRP A NE1 1 ATOM 1782 C CE2 . TRP A 1 219 ? 43.148 70.281 26.877 1.00 52.39 ? 219 TRP A CE2 1 ATOM 1783 C CE3 . TRP A 1 219 ? 44.923 69.582 25.385 1.00 52.46 ? 219 TRP A CE3 1 ATOM 1784 C CZ2 . TRP A 1 219 ? 43.854 71.427 27.260 1.00 52.35 ? 219 TRP A CZ2 1 ATOM 1785 C CZ3 . TRP A 1 219 ? 45.626 70.723 25.766 1.00 52.29 ? 219 TRP A CZ3 1 ATOM 1786 C CH2 . TRP A 1 219 ? 45.087 71.630 26.695 1.00 50.82 ? 219 TRP A CH2 1 ATOM 1787 N N . THR A 1 220 ? 44.648 66.351 22.645 1.00 62.21 ? 220 THR A N 1 ATOM 1788 C CA . THR A 1 220 ? 45.516 65.368 22.017 1.00 64.41 ? 220 THR A CA 1 ATOM 1789 C C . THR A 1 220 ? 46.770 65.265 22.866 1.00 65.58 ? 220 THR A C 1 ATOM 1790 O O . THR A 1 220 ? 47.196 66.239 23.487 1.00 65.70 ? 220 THR A O 1 ATOM 1791 C CB . THR A 1 220 ? 45.925 65.768 20.587 1.00 64.89 ? 220 THR A CB 1 ATOM 1792 O OG1 . THR A 1 220 ? 46.466 67.094 20.594 1.00 65.64 ? 220 THR A OG1 1 ATOM 1793 C CG2 . THR A 1 220 ? 44.730 65.694 19.651 1.00 65.83 ? 220 THR A CG2 1 ATOM 1794 N N . ARG A 1 221 ? 47.343 64.070 22.901 1.00 67.71 ? 221 ARG A N 1 ATOM 1795 C CA . ARG A 1 221 ? 48.552 63.814 23.666 1.00 69.57 ? 221 ARG A CA 1 ATOM 1796 C C . ARG A 1 221 ? 49.492 63.104 22.711 1.00 70.00 ? 221 ARG A C 1 ATOM 1797 O O . ARG A 1 221 ? 49.320 61.920 22.428 1.00 71.02 ? 221 ARG A O 1 ATOM 1798 C CB . ARG A 1 221 ? 48.223 62.929 24.868 1.00 71.18 ? 221 ARG A CB 1 ATOM 1799 C CG . ARG A 1 221 ? 49.341 62.773 25.880 1.00 73.38 ? 221 ARG A CG 1 ATOM 1800 C CD . ARG A 1 221 ? 50.109 61.485 25.667 1.00 74.98 ? 221 ARG A CD 1 ATOM 1801 N NE . ARG A 1 221 ? 51.090 61.269 26.725 1.00 76.15 ? 221 ARG A NE 1 ATOM 1802 C CZ . ARG A 1 221 ? 51.896 60.215 26.788 1.00 76.61 ? 221 ARG A CZ 1 ATOM 1803 N NH1 . ARG A 1 221 ? 51.834 59.278 25.852 1.00 76.99 ? 221 ARG A NH1 1 ATOM 1804 N NH2 . ARG A 1 221 ? 52.766 60.101 27.782 1.00 77.42 ? 221 ARG A NH2 1 ATOM 1805 N N . ALA A 1 222 ? 50.471 63.843 22.198 1.00 70.88 ? 222 ALA A N 1 ATOM 1806 C CA . ALA A 1 222 ? 51.430 63.300 21.245 1.00 71.12 ? 222 ALA A CA 1 ATOM 1807 C C . ALA A 1 222 ? 50.701 62.967 19.947 1.00 71.50 ? 222 ALA A C 1 ATOM 1808 O O . ALA A 1 222 ? 50.943 61.928 19.332 1.00 71.12 ? 222 ALA A O 1 ATOM 1809 C CB . ALA A 1 222 ? 52.100 62.052 21.814 1.00 71.41 ? 222 ALA A CB 1 ATOM 1810 N N . GLY A 1 223 ? 49.798 63.857 19.543 1.00 71.93 ? 223 GLY A N 1 ATOM 1811 C CA . GLY A 1 223 ? 49.043 63.651 18.320 1.00 72.59 ? 223 GLY A CA 1 ATOM 1812 C C . GLY A 1 223 ? 47.954 62.607 18.465 1.00 73.54 ? 223 GLY A C 1 ATOM 1813 O O . GLY A 1 223 ? 47.280 62.262 17.493 1.00 73.36 ? 223 GLY A O 1 ATOM 1814 N N . GLU A 1 224 ? 47.780 62.104 19.683 1.00 73.98 ? 224 GLU A N 1 ATOM 1815 C CA . GLU A 1 224 ? 46.768 61.092 19.957 1.00 74.55 ? 224 GLU A CA 1 ATOM 1816 C C . GLU A 1 224 ? 45.576 61.695 20.689 1.00 74.11 ? 224 GLU A C 1 ATOM 1817 O O . GLU A 1 224 ? 45.720 62.228 21.790 1.00 73.77 ? 224 GLU A O 1 ATOM 1818 C CB . GLU A 1 224 ? 47.367 59.967 20.809 1.00 76.08 ? 224 GLU A CB 1 ATOM 1819 C CG . GLU A 1 224 ? 48.503 59.209 20.142 1.00 77.45 ? 224 GLU A CG 1 ATOM 1820 C CD . GLU A 1 224 ? 48.065 58.502 18.875 1.00 77.91 ? 224 GLU A CD 1 ATOM 1821 O OE1 . GLU A 1 224 ? 47.151 57.653 18.954 1.00 78.70 ? 224 GLU A OE1 1 ATOM 1822 O OE2 . GLU A 1 224 ? 48.633 58.793 17.801 1.00 78.10 ? 224 GLU A OE2 1 ATOM 1823 N N . VAL A 1 225 ? 44.400 61.613 20.075 1.00 73.20 ? 225 VAL A N 1 ATOM 1824 C CA . VAL A 1 225 ? 43.191 62.144 20.693 1.00 72.73 ? 225 VAL A CA 1 ATOM 1825 C C . VAL A 1 225 ? 43.001 61.479 22.050 1.00 72.07 ? 225 VAL A C 1 ATOM 1826 O O . VAL A 1 225 ? 43.088 60.258 22.171 1.00 71.95 ? 225 VAL A O 1 ATOM 1827 C CB . VAL A 1 225 ? 41.948 61.876 19.820 1.00 73.08 ? 225 VAL A CB 1 ATOM 1828 C CG1 . VAL A 1 225 ? 41.851 60.397 19.493 1.00 74.10 ? 225 VAL A CG1 1 ATOM 1829 C CG2 . VAL A 1 225 ? 40.697 62.343 20.545 1.00 73.18 ? 225 VAL A CG2 1 ATOM 1830 N N . GLN A 1 226 ? 42.746 62.288 23.070 1.00 71.37 ? 226 GLN A N 1 ATOM 1831 C CA . GLN A 1 226 ? 42.560 61.772 24.418 1.00 70.57 ? 226 GLN A CA 1 ATOM 1832 C C . GLN A 1 226 ? 41.096 61.697 24.825 1.00 70.37 ? 226 GLN A C 1 ATOM 1833 O O . GLN A 1 226 ? 40.227 62.307 24.202 1.00 70.04 ? 226 GLN A O 1 ATOM 1834 C CB . GLN A 1 226 ? 43.321 62.644 25.418 1.00 70.99 ? 226 GLN A CB 1 ATOM 1835 C CG . GLN A 1 226 ? 44.814 62.707 25.155 1.00 72.21 ? 226 GLN A CG 1 ATOM 1836 C CD . GLN A 1 226 ? 45.485 61.355 25.295 1.00 71.67 ? 226 GLN A CD 1 ATOM 1837 O OE1 . GLN A 1 226 ? 45.665 60.853 26.403 1.00 72.11 ? 226 GLN A OE1 1 ATOM 1838 N NE2 . GLN A 1 226 ? 45.849 60.755 24.168 1.00 71.69 ? 226 GLN A NE2 1 ATOM 1839 N N . GLU A 1 227 ? 40.837 60.932 25.879 1.00 70.06 ? 227 GLU A N 1 ATOM 1840 C CA . GLU A 1 227 ? 39.493 60.768 26.412 1.00 68.52 ? 227 GLU A CA 1 ATOM 1841 C C . GLU A 1 227 ? 39.342 61.803 27.515 1.00 66.01 ? 227 GLU A C 1 ATOM 1842 O O . GLU A 1 227 ? 40.089 61.791 28.492 1.00 65.49 ? 227 GLU A O 1 ATOM 1843 C CB . GLU A 1 227 ? 39.328 59.360 26.988 1.00 71.61 ? 227 GLU A CB 1 ATOM 1844 C CG . GLU A 1 227 ? 37.991 59.097 27.669 1.00 74.98 ? 227 GLU A CG 1 ATOM 1845 C CD . GLU A 1 227 ? 36.810 59.267 26.732 1.00 76.86 ? 227 GLU A CD 1 ATOM 1846 O OE1 . GLU A 1 227 ? 36.812 58.640 25.651 1.00 77.67 ? 227 GLU A OE1 1 ATOM 1847 O OE2 . GLU A 1 227 ? 35.878 60.023 27.082 1.00 78.01 ? 227 GLU A OE2 1 ATOM 1848 N N . PRO A 1 228 ? 38.383 62.728 27.365 1.00 64.11 ? 228 PRO A N 1 ATOM 1849 C CA . PRO A 1 228 ? 38.179 63.760 28.385 1.00 63.26 ? 228 PRO A CA 1 ATOM 1850 C C . PRO A 1 228 ? 37.728 63.222 29.742 1.00 62.65 ? 228 PRO A C 1 ATOM 1851 O O . PRO A 1 228 ? 36.956 62.269 29.821 1.00 62.12 ? 228 PRO A O 1 ATOM 1852 C CB . PRO A 1 228 ? 37.142 64.679 27.740 1.00 62.34 ? 228 PRO A CB 1 ATOM 1853 C CG . PRO A 1 228 ? 36.368 63.756 26.863 1.00 62.99 ? 228 PRO A CG 1 ATOM 1854 C CD . PRO A 1 228 ? 37.449 62.908 26.241 1.00 63.08 ? 228 PRO A CD 1 ATOM 1855 N N . GLU A 1 229 ? 38.235 63.841 30.803 1.00 62.11 ? 229 GLU A N 1 ATOM 1856 C CA . GLU A 1 229 ? 37.894 63.465 32.167 1.00 61.93 ? 229 GLU A CA 1 ATOM 1857 C C . GLU A 1 229 ? 36.622 64.197 32.582 1.00 62.77 ? 229 GLU A C 1 ATOM 1858 O O . GLU A 1 229 ? 35.863 63.725 33.430 1.00 63.25 ? 229 GLU A O 1 ATOM 1859 C CB . GLU A 1 229 ? 39.041 63.833 33.113 1.00 61.46 ? 229 GLU A CB 1 ATOM 1860 C CG . GLU A 1 229 ? 38.679 63.785 34.590 1.00 62.37 ? 229 GLU A CG 1 ATOM 1861 C CD . GLU A 1 229 ? 39.887 63.920 35.498 1.00 62.95 ? 229 GLU A CD 1 ATOM 1862 O OE1 . GLU A 1 229 ? 40.719 62.986 35.521 1.00 62.83 ? 229 GLU A OE1 1 ATOM 1863 O OE2 . GLU A 1 229 ? 40.008 64.957 36.188 1.00 63.34 ? 229 GLU A OE2 1 ATOM 1864 N N . LEU A 1 230 ? 36.399 65.357 31.974 1.00 61.99 ? 230 LEU A N 1 ATOM 1865 C CA . LEU A 1 230 ? 35.225 66.171 32.258 1.00 61.74 ? 230 LEU A CA 1 ATOM 1866 C C . LEU A 1 230 ? 34.900 66.989 31.015 1.00 61.54 ? 230 LEU A C 1 ATOM 1867 O O . LEU A 1 230 ? 35.796 67.511 30.350 1.00 62.51 ? 230 LEU A O 1 ATOM 1868 C CB . LEU A 1 230 ? 35.498 67.103 33.440 1.00 61.61 ? 230 LEU A CB 1 ATOM 1869 C CG . LEU A 1 230 ? 34.309 67.929 33.934 1.00 61.97 ? 230 LEU A CG 1 ATOM 1870 C CD1 . LEU A 1 230 ? 33.220 66.997 34.444 1.00 62.85 ? 230 LEU A CD1 1 ATOM 1871 C CD2 . LEU A 1 230 ? 34.760 68.871 35.038 1.00 61.34 ? 230 LEU A CD2 1 ATOM 1872 N N . ARG A 1 231 ? 33.617 67.095 30.697 1.00 59.67 ? 231 ARG A N 1 ATOM 1873 C CA . ARG A 1 231 ? 33.192 67.836 29.520 1.00 57.31 ? 231 ARG A CA 1 ATOM 1874 C C . ARG A 1 231 ? 31.922 68.621 29.815 1.00 54.88 ? 231 ARG A C 1 ATOM 1875 O O . ARG A 1 231 ? 31.170 68.279 30.730 1.00 54.88 ? 231 ARG A O 1 ATOM 1876 C CB . ARG A 1 231 ? 32.948 66.863 28.366 1.00 59.01 ? 231 ARG A CB 1 ATOM 1877 C CG . ARG A 1 231 ? 32.487 67.516 27.082 1.00 63.39 ? 231 ARG A CG 1 ATOM 1878 C CD . ARG A 1 231 ? 32.175 66.472 26.029 1.00 66.73 ? 231 ARG A CD 1 ATOM 1879 N NE . ARG A 1 231 ? 33.357 65.699 25.661 1.00 70.43 ? 231 ARG A NE 1 ATOM 1880 C CZ . ARG A 1 231 ? 33.340 64.664 24.829 1.00 71.91 ? 231 ARG A CZ 1 ATOM 1881 N NH1 . ARG A 1 231 ? 32.197 64.276 24.278 1.00 72.60 ? 231 ARG A NH1 1 ATOM 1882 N NH2 . ARG A 1 231 ? 34.464 64.019 24.546 1.00 73.15 ? 231 ARG A NH2 1 ATOM 1883 N N . GLY A 1 232 ? 31.686 69.676 29.044 1.00 50.74 ? 232 GLY A N 1 ATOM 1884 C CA . GLY A 1 232 ? 30.494 70.474 29.250 1.00 46.48 ? 232 GLY A CA 1 ATOM 1885 C C . GLY A 1 232 ? 30.357 71.610 28.259 1.00 45.29 ? 232 GLY A C 1 ATOM 1886 O O . GLY A 1 232 ? 31.276 71.894 27.492 1.00 44.42 ? 232 GLY A O 1 ATOM 1887 N N . ASP A 1 233 ? 29.195 72.252 28.264 1.00 42.46 ? 233 ASP A N 1 ATOM 1888 C CA . ASP A 1 233 ? 28.942 73.380 27.381 1.00 38.77 ? 233 ASP A CA 1 ATOM 1889 C C . ASP A 1 233 ? 27.749 74.168 27.887 1.00 37.57 ? 233 ASP A C 1 ATOM 1890 O O . ASP A 1 233 ? 27.075 73.756 28.833 1.00 38.16 ? 233 ASP A O 1 ATOM 1891 C CB . ASP A 1 233 ? 28.716 72.918 25.934 1.00 39.03 ? 233 ASP A CB 1 ATOM 1892 C CG . ASP A 1 233 ? 27.602 71.905 25.801 1.00 39.04 ? 233 ASP A CG 1 ATOM 1893 O OD1 . ASP A 1 233 ? 26.503 72.151 26.334 1.00 40.83 ? 233 ASP A OD1 1 ATOM 1894 O OD2 . ASP A 1 233 ? 27.822 70.867 25.146 1.00 39.89 ? 233 ASP A OD2 1 ATOM 1895 N N . VAL A 1 234 ? 27.491 75.308 27.262 1.00 34.24 ? 234 VAL A N 1 ATOM 1896 C CA . VAL A 1 234 ? 26.397 76.160 27.684 1.00 31.36 ? 234 VAL A CA 1 ATOM 1897 C C . VAL A 1 234 ? 26.057 77.157 26.585 1.00 32.31 ? 234 VAL A C 1 ATOM 1898 O O . VAL A 1 234 ? 26.842 77.369 25.655 1.00 33.08 ? 234 VAL A O 1 ATOM 1899 C CB . VAL A 1 234 ? 26.788 76.939 28.975 1.00 31.27 ? 234 VAL A CB 1 ATOM 1900 C CG1 . VAL A 1 234 ? 27.974 77.872 28.693 1.00 31.43 ? 234 VAL A CG1 1 ATOM 1901 C CG2 . VAL A 1 234 ? 25.605 77.733 29.499 1.00 31.33 ? 234 VAL A CG2 1 ATOM 1902 N N . LEU A 1 235 ? 24.867 77.738 26.688 1.00 31.59 ? 235 LEU A N 1 ATOM 1903 C CA . LEU A 1 235 ? 24.412 78.756 25.756 1.00 30.83 ? 235 LEU A CA 1 ATOM 1904 C C . LEU A 1 235 ? 24.005 79.938 26.607 1.00 30.62 ? 235 LEU A C 1 ATOM 1905 O O . LEU A 1 235 ? 23.216 79.790 27.539 1.00 31.28 ? 235 LEU A O 1 ATOM 1906 C CB . LEU A 1 235 ? 23.196 78.292 24.950 1.00 29.33 ? 235 LEU A CB 1 ATOM 1907 C CG . LEU A 1 235 ? 22.337 79.465 24.449 1.00 29.59 ? 235 LEU A CG 1 ATOM 1908 C CD1 . LEU A 1 235 ? 23.088 80.207 23.341 1.00 28.06 ? 235 LEU A CD1 1 ATOM 1909 C CD2 . LEU A 1 235 ? 20.994 78.958 23.941 1.00 30.18 ? 235 LEU A CD2 1 ATOM 1910 N N . HIS A 1 236 ? 24.569 81.100 26.307 1.00 30.40 ? 236 HIS A N 1 ATOM 1911 C CA . HIS A 1 236 ? 24.231 82.316 27.023 1.00 29.75 ? 236 HIS A CA 1 ATOM 1912 C C . HIS A 1 236 ? 23.256 83.029 26.106 1.00 30.77 ? 236 HIS A C 1 ATOM 1913 O O . HIS A 1 236 ? 23.637 83.516 25.042 1.00 28.91 ? 236 HIS A O 1 ATOM 1914 C CB . HIS A 1 236 ? 25.484 83.156 27.251 1.00 32.24 ? 236 HIS A CB 1 ATOM 1915 C CG . HIS A 1 236 ? 26.480 82.502 28.155 1.00 34.59 ? 236 HIS A CG 1 ATOM 1916 N ND1 . HIS A 1 236 ? 26.215 82.238 29.481 1.00 34.99 ? 236 HIS A ND1 1 ATOM 1917 C CD2 . HIS A 1 236 ? 27.733 82.045 27.922 1.00 34.76 ? 236 HIS A CD2 1 ATOM 1918 C CE1 . HIS A 1 236 ? 27.263 81.646 30.026 1.00 36.66 ? 236 HIS A CE1 1 ATOM 1919 N NE2 . HIS A 1 236 ? 28.197 81.517 29.102 1.00 36.18 ? 236 HIS A NE2 1 ATOM 1920 N N . ASN A 1 237 ? 21.994 83.078 26.513 1.00 30.39 ? 237 ASN A N 1 ATOM 1921 C CA . ASN A 1 237 ? 20.967 83.695 25.688 1.00 32.11 ? 237 ASN A CA 1 ATOM 1922 C C . ASN A 1 237 ? 21.079 85.209 25.563 1.00 31.77 ? 237 ASN A C 1 ATOM 1923 O O . ASN A 1 237 ? 20.723 85.774 24.529 1.00 32.58 ? 237 ASN A O 1 ATOM 1924 C CB . ASN A 1 237 ? 19.575 83.346 26.223 1.00 29.92 ? 237 ASN A CB 1 ATOM 1925 C CG . ASN A 1 237 ? 18.489 83.595 25.197 1.00 30.96 ? 237 ASN A CG 1 ATOM 1926 O OD1 . ASN A 1 237 ? 18.328 82.819 24.249 1.00 30.90 ? 237 ASN A OD1 1 ATOM 1927 N ND2 . ASN A 1 237 ? 17.749 84.686 25.365 1.00 29.75 ? 237 ASN A ND2 1 ATOM 1928 N N . GLY A 1 238 ? 21.548 85.869 26.616 1.00 31.60 ? 238 GLY A N 1 ATOM 1929 C CA . GLY A 1 238 ? 21.661 87.315 26.567 1.00 32.20 ? 238 GLY A CA 1 ATOM 1930 C C . GLY A 1 238 ? 22.531 87.740 25.401 1.00 33.01 ? 238 GLY A C 1 ATOM 1931 O O . GLY A 1 238 ? 22.254 88.725 24.724 1.00 33.53 ? 238 GLY A O 1 ATOM 1932 N N . ASN A 1 239 ? 23.556 86.930 25.166 1.00 33.59 ? 239 ASN A N 1 ATOM 1933 C CA . ASN A 1 239 ? 24.583 87.106 24.141 1.00 36.53 ? 239 ASN A CA 1 ATOM 1934 C C . ASN A 1 239 ? 24.344 86.340 22.840 1.00 34.66 ? 239 ASN A C 1 ATOM 1935 O O . ASN A 1 239 ? 24.834 86.727 21.774 1.00 34.84 ? 239 ASN A O 1 ATOM 1936 C CB . ASN A 1 239 ? 25.910 86.597 24.708 1.00 41.10 ? 239 ASN A CB 1 ATOM 1937 C CG . ASN A 1 239 ? 26.990 87.616 24.650 1.00 46.58 ? 239 ASN A CG 1 ATOM 1938 O OD1 . ASN A 1 239 ? 27.255 88.185 23.591 1.00 54.80 ? 239 ASN A OD1 1 ATOM 1939 N ND2 . ASN A 1 239 ? 27.627 87.861 25.789 1.00 47.64 ? 239 ASN A ND2 1 ATOM 1940 N N . GLY A 1 240 ? 23.647 85.217 22.939 1.00 31.98 ? 240 GLY A N 1 ATOM 1941 C CA . GLY A 1 240 ? 23.425 84.401 21.764 1.00 29.68 ? 240 GLY A CA 1 ATOM 1942 C C . GLY A 1 240 ? 24.711 83.671 21.419 1.00 29.90 ? 240 GLY A C 1 ATOM 1943 O O . GLY A 1 240 ? 24.965 83.372 20.257 1.00 30.17 ? 240 GLY A O 1 ATOM 1944 N N . THR A 1 241 ? 25.532 83.377 22.426 1.00 28.35 ? 241 THR A N 1 ATOM 1945 C CA . THR A 1 241 ? 26.789 82.678 22.186 1.00 28.91 ? 241 THR A CA 1 ATOM 1946 C C . THR A 1 241 ? 26.936 81.424 23.035 1.00 30.14 ? 241 THR A C 1 ATOM 1947 O O . THR A 1 241 ? 26.353 81.312 24.114 1.00 28.91 ? 241 THR A O 1 ATOM 1948 C CB . THR A 1 241 ? 28.018 83.577 22.479 1.00 30.43 ? 241 THR A CB 1 ATOM 1949 O OG1 . THR A 1 241 ? 28.061 83.883 23.880 1.00 31.26 ? 241 THR A OG1 1 ATOM 1950 C CG2 . THR A 1 241 ? 27.945 84.882 21.668 1.00 29.79 ? 241 THR A CG2 1 ATOM 1951 N N . TYR A 1 242 ? 27.731 80.487 22.534 1.00 30.64 ? 242 TYR A N 1 ATOM 1952 C CA . TYR A 1 242 ? 27.990 79.241 23.234 1.00 32.12 ? 242 TYR A CA 1 ATOM 1953 C C . TYR A 1 242 ? 29.405 79.214 23.789 1.00 34.59 ? 242 TYR A C 1 ATOM 1954 O O . TYR A 1 242 ? 30.250 80.049 23.450 1.00 33.15 ? 242 TYR A O 1 ATOM 1955 C CB . TYR A 1 242 ? 27.828 78.042 22.297 1.00 30.65 ? 242 TYR A CB 1 ATOM 1956 C CG . TYR A 1 242 ? 26.397 77.687 21.940 1.00 33.58 ? 242 TYR A CG 1 ATOM 1957 C CD1 . TYR A 1 242 ? 25.703 78.386 20.951 1.00 31.91 ? 242 TYR A CD1 1 ATOM 1958 C CD2 . TYR A 1 242 ? 25.741 76.637 22.590 1.00 32.12 ? 242 TYR A CD2 1 ATOM 1959 C CE1 . TYR A 1 242 ? 24.386 78.045 20.616 1.00 31.81 ? 242 TYR A CE1 1 ATOM 1960 C CE2 . TYR A 1 242 ? 24.434 76.287 22.266 1.00 31.93 ? 242 TYR A CE2 1 ATOM 1961 C CZ . TYR A 1 242 ? 23.761 76.992 21.281 1.00 33.31 ? 242 TYR A CZ 1 ATOM 1962 O OH . TYR A 1 242 ? 22.467 76.645 20.964 1.00 31.03 ? 242 TYR A OH 1 ATOM 1963 N N . GLN A 1 243 ? 29.641 78.237 24.655 1.00 34.95 ? 243 GLN A N 1 ATOM 1964 C CA . GLN A 1 243 ? 30.937 77.997 25.265 1.00 35.14 ? 243 GLN A CA 1 ATOM 1965 C C . GLN A 1 243 ? 30.954 76.492 25.434 1.00 37.67 ? 243 GLN A C 1 ATOM 1966 O O . GLN A 1 243 ? 29.931 75.895 25.773 1.00 39.05 ? 243 GLN A O 1 ATOM 1967 C CB . GLN A 1 243 ? 31.059 78.692 26.621 1.00 33.35 ? 243 GLN A CB 1 ATOM 1968 C CG . GLN A 1 243 ? 31.115 80.197 26.533 1.00 33.96 ? 243 GLN A CG 1 ATOM 1969 C CD . GLN A 1 243 ? 31.695 80.836 27.780 1.00 35.02 ? 243 GLN A CD 1 ATOM 1970 O OE1 . GLN A 1 243 ? 32.523 80.241 28.465 1.00 36.83 ? 243 GLN A OE1 1 ATOM 1971 N NE2 . GLN A 1 243 ? 31.285 82.061 28.063 1.00 35.30 ? 243 GLN A NE2 1 ATOM 1972 N N . SER A 1 244 ? 32.099 75.878 25.171 1.00 38.06 ? 244 SER A N 1 ATOM 1973 C CA . SER A 1 244 ? 32.231 74.433 25.272 1.00 40.35 ? 244 SER A CA 1 ATOM 1974 C C . SER A 1 244 ? 33.631 74.124 25.781 1.00 43.52 ? 244 SER A C 1 ATOM 1975 O O . SER A 1 244 ? 34.619 74.651 25.257 1.00 43.97 ? 244 SER A O 1 ATOM 1976 C CB . SER A 1 244 ? 32.006 73.806 23.893 1.00 40.32 ? 244 SER A CB 1 ATOM 1977 O OG . SER A 1 244 ? 32.037 72.392 23.942 1.00 41.55 ? 244 SER A OG 1 ATOM 1978 N N . TRP A 1 245 ? 33.720 73.281 26.807 1.00 44.36 ? 245 TRP A N 1 ATOM 1979 C CA . TRP A 1 245 ? 35.015 72.935 27.384 1.00 44.90 ? 245 TRP A CA 1 ATOM 1980 C C . TRP A 1 245 ? 35.255 71.441 27.538 1.00 46.85 ? 245 TRP A C 1 ATOM 1981 O O . TRP A 1 245 ? 34.319 70.641 27.609 1.00 45.11 ? 245 TRP A O 1 ATOM 1982 C CB . TRP A 1 245 ? 35.182 73.629 28.738 1.00 45.54 ? 245 TRP A CB 1 ATOM 1983 C CG . TRP A 1 245 ? 34.120 73.280 29.730 1.00 49.21 ? 245 TRP A CG 1 ATOM 1984 C CD1 . TRP A 1 245 ? 34.148 72.261 30.642 1.00 50.75 ? 245 TRP A CD1 1 ATOM 1985 C CD2 . TRP A 1 245 ? 32.856 73.929 29.894 1.00 50.36 ? 245 TRP A CD2 1 ATOM 1986 N NE1 . TRP A 1 245 ? 32.978 72.239 31.363 1.00 50.83 ? 245 TRP A NE1 1 ATOM 1987 C CE2 . TRP A 1 245 ? 32.167 73.252 30.924 1.00 51.01 ? 245 TRP A CE2 1 ATOM 1988 C CE3 . TRP A 1 245 ? 32.235 75.019 29.269 1.00 51.61 ? 245 TRP A CE3 1 ATOM 1989 C CZ2 . TRP A 1 245 ? 30.886 73.629 31.345 1.00 51.52 ? 245 TRP A CZ2 1 ATOM 1990 C CZ3 . TRP A 1 245 ? 30.959 75.394 29.689 1.00 51.93 ? 245 TRP A CZ3 1 ATOM 1991 C CH2 . TRP A 1 245 ? 30.301 74.699 30.718 1.00 51.71 ? 245 TRP A CH2 1 ATOM 1992 N N . VAL A 1 246 ? 36.532 71.079 27.576 1.00 48.06 ? 246 VAL A N 1 ATOM 1993 C CA . VAL A 1 246 ? 36.961 69.697 27.728 1.00 49.56 ? 246 VAL A CA 1 ATOM 1994 C C . VAL A 1 246 ? 38.151 69.698 28.681 1.00 51.48 ? 246 VAL A C 1 ATOM 1995 O O . VAL A 1 246 ? 39.026 70.564 28.591 1.00 51.90 ? 246 VAL A O 1 ATOM 1996 C CB . VAL A 1 246 ? 37.389 69.094 26.375 1.00 49.17 ? 246 VAL A CB 1 ATOM 1997 C CG1 . VAL A 1 246 ? 38.003 67.729 26.588 1.00 51.62 ? 246 VAL A CG1 1 ATOM 1998 C CG2 . VAL A 1 246 ? 36.186 68.979 25.453 1.00 49.04 ? 246 VAL A CG2 1 ATOM 1999 N N . VAL A 1 247 ? 38.180 68.740 29.600 1.00 51.96 ? 247 VAL A N 1 ATOM 2000 C CA . VAL A 1 247 ? 39.267 68.661 30.566 1.00 53.80 ? 247 VAL A CA 1 ATOM 2001 C C . VAL A 1 247 ? 39.926 67.291 30.588 1.00 55.20 ? 247 VAL A C 1 ATOM 2002 O O . VAL A 1 247 ? 39.258 66.267 30.443 1.00 55.63 ? 247 VAL A O 1 ATOM 2003 C CB . VAL A 1 247 ? 38.772 68.976 31.991 1.00 54.15 ? 247 VAL A CB 1 ATOM 2004 C CG1 . VAL A 1 247 ? 39.917 68.843 32.983 1.00 53.86 ? 247 VAL A CG1 1 ATOM 2005 C CG2 . VAL A 1 247 ? 38.189 70.376 32.041 1.00 53.58 ? 247 VAL A CG2 1 ATOM 2006 N N . VAL A 1 248 ? 41.244 67.283 30.758 1.00 56.17 ? 248 VAL A N 1 ATOM 2007 C CA . VAL A 1 248 ? 42.005 66.042 30.829 1.00 57.41 ? 248 VAL A CA 1 ATOM 2008 C C . VAL A 1 248 ? 43.007 66.116 31.969 1.00 58.74 ? 248 VAL A C 1 ATOM 2009 O O . VAL A 1 248 ? 43.517 67.189 32.297 1.00 57.52 ? 248 VAL A O 1 ATOM 2010 C CB . VAL A 1 248 ? 42.783 65.752 29.525 1.00 56.67 ? 248 VAL A CB 1 ATOM 2011 C CG1 . VAL A 1 248 ? 41.820 65.359 28.421 1.00 55.52 ? 248 VAL A CG1 1 ATOM 2012 C CG2 . VAL A 1 248 ? 43.607 66.970 29.127 1.00 56.99 ? 248 VAL A CG2 1 ATOM 2013 N N . ALA A 1 249 ? 43.268 64.967 32.582 1.00 61.31 ? 249 ALA A N 1 ATOM 2014 C CA . ALA A 1 249 ? 44.221 64.881 33.678 1.00 63.23 ? 249 ALA A CA 1 ATOM 2015 C C . ALA A 1 249 ? 45.527 64.360 33.092 1.00 63.93 ? 249 ALA A C 1 ATOM 2016 O O . ALA A 1 249 ? 45.521 63.469 32.241 1.00 63.41 ? 249 ALA A O 1 ATOM 2017 C CB . ALA A 1 249 ? 43.702 63.932 34.752 1.00 62.92 ? 249 ALA A CB 1 ATOM 2018 N N . VAL A 1 250 ? 46.646 64.919 33.539 1.00 65.58 ? 250 VAL A N 1 ATOM 2019 C CA . VAL A 1 250 ? 47.943 64.495 33.030 1.00 68.49 ? 250 VAL A CA 1 ATOM 2020 C C . VAL A 1 250 ? 48.835 63.888 34.111 1.00 70.17 ? 250 VAL A C 1 ATOM 2021 O O . VAL A 1 250 ? 49.030 64.476 35.178 1.00 69.66 ? 250 VAL A O 1 ATOM 2022 C CB . VAL A 1 250 ? 48.691 65.678 32.367 1.00 68.81 ? 250 VAL A CB 1 ATOM 2023 C CG1 . VAL A 1 250 ? 48.945 66.777 33.388 1.00 68.18 ? 250 VAL A CG1 1 ATOM 2024 C CG2 . VAL A 1 250 ? 49.998 65.191 31.758 1.00 68.89 ? 250 VAL A CG2 1 ATOM 2025 N N . PRO A 1 251 ? 49.379 62.688 33.848 1.00 72.21 ? 251 PRO A N 1 ATOM 2026 C CA . PRO A 1 251 ? 50.258 62.000 34.798 1.00 74.35 ? 251 PRO A CA 1 ATOM 2027 C C . PRO A 1 251 ? 51.355 62.947 35.286 1.00 76.88 ? 251 PRO A C 1 ATOM 2028 O O . PRO A 1 251 ? 51.961 63.670 34.491 1.00 77.02 ? 251 PRO A O 1 ATOM 2029 C CB . PRO A 1 251 ? 50.811 60.846 33.972 1.00 73.97 ? 251 PRO A CB 1 ATOM 2030 C CG . PRO A 1 251 ? 49.654 60.505 33.081 1.00 73.37 ? 251 PRO A CG 1 ATOM 2031 C CD . PRO A 1 251 ? 49.169 61.870 32.639 1.00 72.66 ? 251 PRO A CD 1 ATOM 2032 N N . PRO A 1 252 ? 51.630 62.950 36.600 1.00 79.21 ? 252 PRO A N 1 ATOM 2033 C CA . PRO A 1 252 ? 52.658 63.821 37.181 1.00 80.56 ? 252 PRO A CA 1 ATOM 2034 C C . PRO A 1 252 ? 54.054 63.669 36.580 1.00 81.61 ? 252 PRO A C 1 ATOM 2035 O O . PRO A 1 252 ? 54.930 64.499 36.823 1.00 81.87 ? 252 PRO A O 1 ATOM 2036 C CB . PRO A 1 252 ? 52.618 63.457 38.664 1.00 80.49 ? 252 PRO A CB 1 ATOM 2037 C CG . PRO A 1 252 ? 52.218 62.012 38.640 1.00 80.60 ? 252 PRO A CG 1 ATOM 2038 C CD . PRO A 1 252 ? 51.114 62.007 37.609 1.00 79.82 ? 252 PRO A CD 1 ATOM 2039 N N . GLN A 1 253 ? 54.260 62.619 35.791 1.00 82.79 ? 253 GLN A N 1 ATOM 2040 C CA . GLN A 1 253 ? 55.562 62.389 35.176 1.00 84.27 ? 253 GLN A CA 1 ATOM 2041 C C . GLN A 1 253 ? 55.495 62.472 33.654 1.00 84.17 ? 253 GLN A C 1 ATOM 2042 O O . GLN A 1 253 ? 56.500 62.275 32.971 1.00 84.15 ? 253 GLN A O 1 ATOM 2043 C CB . GLN A 1 253 ? 56.106 61.019 35.592 1.00 85.79 ? 253 GLN A CB 1 ATOM 2044 C CG . GLN A 1 253 ? 57.581 60.811 35.273 1.00 87.40 ? 253 GLN A CG 1 ATOM 2045 C CD . GLN A 1 253 ? 58.051 59.398 35.566 1.00 88.76 ? 253 GLN A CD 1 ATOM 2046 O OE1 . GLN A 1 253 ? 57.854 58.882 36.667 1.00 90.20 ? 253 GLN A OE1 1 ATOM 2047 N NE2 . GLN A 1 253 ? 58.681 58.766 34.581 1.00 88.67 ? 253 GLN A NE2 1 ATOM 2048 N N . ASP A 1 254 ? 54.312 62.767 33.125 1.00 84.22 ? 254 ASP A N 1 ATOM 2049 C CA . ASP A 1 254 ? 54.135 62.867 31.680 1.00 83.94 ? 254 ASP A CA 1 ATOM 2050 C C . ASP A 1 254 ? 54.783 64.140 31.143 1.00 83.24 ? 254 ASP A C 1 ATOM 2051 O O . ASP A 1 254 ? 54.642 65.215 31.728 1.00 82.78 ? 254 ASP A O 1 ATOM 2052 C CB . ASP A 1 254 ? 52.646 62.855 31.324 1.00 84.33 ? 254 ASP A CB 1 ATOM 2053 C CG . ASP A 1 254 ? 52.404 62.694 29.835 1.00 84.93 ? 254 ASP A CG 1 ATOM 2054 O OD1 . ASP A 1 254 ? 52.914 63.523 29.053 1.00 85.80 ? 254 ASP A OD1 1 ATOM 2055 O OD2 . ASP A 1 254 ? 51.703 61.739 29.445 1.00 85.47 ? 254 ASP A OD2 1 ATOM 2056 N N . THR A 1 255 ? 55.492 64.008 30.026 1.00 82.39 ? 255 THR A N 1 ATOM 2057 C CA . THR A 1 255 ? 56.171 65.139 29.403 1.00 81.52 ? 255 THR A CA 1 ATOM 2058 C C . THR A 1 255 ? 55.644 65.371 27.992 1.00 80.32 ? 255 THR A C 1 ATOM 2059 O O . THR A 1 255 ? 55.924 66.400 27.378 1.00 80.31 ? 255 THR A O 1 ATOM 2060 C CB . THR A 1 255 ? 57.696 64.898 29.319 1.00 81.90 ? 255 THR A CB 1 ATOM 2061 O OG1 . THR A 1 255 ? 58.199 64.536 30.611 1.00 82.01 ? 255 THR A OG1 1 ATOM 2062 C CG2 . THR A 1 255 ? 58.409 66.159 28.846 1.00 82.44 ? 255 THR A CG2 1 ATOM 2063 N N . ALA A 1 256 ? 54.880 64.408 27.485 1.00 79.22 ? 256 ALA A N 1 ATOM 2064 C CA . ALA A 1 256 ? 54.309 64.494 26.144 1.00 78.04 ? 256 ALA A CA 1 ATOM 2065 C C . ALA A 1 256 ? 53.666 65.856 25.874 1.00 76.96 ? 256 ALA A C 1 ATOM 2066 O O . ALA A 1 256 ? 53.275 66.569 26.800 1.00 76.28 ? 256 ALA A O 1 ATOM 2067 C CB . ALA A 1 256 ? 53.284 63.386 25.945 1.00 78.01 ? 256 ALA A CB 1 ATOM 2068 N N . PRO A 1 257 ? 53.554 66.234 24.590 1.00 75.95 ? 257 PRO A N 1 ATOM 2069 C CA . PRO A 1 257 ? 52.959 67.514 24.194 1.00 74.77 ? 257 PRO A CA 1 ATOM 2070 C C . PRO A 1 257 ? 51.433 67.483 24.140 1.00 73.59 ? 257 PRO A C 1 ATOM 2071 O O . PRO A 1 257 ? 50.842 66.625 23.480 1.00 73.18 ? 257 PRO A O 1 ATOM 2072 C CB . PRO A 1 257 ? 53.576 67.758 22.824 1.00 74.14 ? 257 PRO A CB 1 ATOM 2073 C CG . PRO A 1 257 ? 53.618 66.372 22.256 1.00 74.77 ? 257 PRO A CG 1 ATOM 2074 C CD . PRO A 1 257 ? 54.137 65.546 23.421 1.00 75.20 ? 257 PRO A CD 1 ATOM 2075 N N . TYR A 1 258 ? 50.800 68.424 24.835 1.00 72.65 ? 258 TYR A N 1 ATOM 2076 C CA . TYR A 1 258 ? 49.344 68.513 24.849 1.00 71.35 ? 258 TYR A CA 1 ATOM 2077 C C . TYR A 1 258 ? 48.861 69.718 24.055 1.00 69.54 ? 258 TYR A C 1 ATOM 2078 O O . TYR A 1 258 ? 49.349 70.834 24.240 1.00 69.13 ? 258 TYR A O 1 ATOM 2079 C CB . TYR A 1 258 ? 48.820 68.607 26.283 1.00 72.56 ? 258 TYR A CB 1 ATOM 2080 C CG . TYR A 1 258 ? 48.866 67.301 27.043 1.00 74.31 ? 258 TYR A CG 1 ATOM 2081 C CD1 . TYR A 1 258 ? 50.068 66.796 27.537 1.00 74.27 ? 258 TYR A CD1 1 ATOM 2082 C CD2 . TYR A 1 258 ? 47.704 66.561 27.257 1.00 74.72 ? 258 TYR A CD2 1 ATOM 2083 C CE1 . TYR A 1 258 ? 50.111 65.584 28.227 1.00 74.62 ? 258 TYR A CE1 1 ATOM 2084 C CE2 . TYR A 1 258 ? 47.736 65.351 27.943 1.00 75.26 ? 258 TYR A CE2 1 ATOM 2085 C CZ . TYR A 1 258 ? 48.940 64.869 28.424 1.00 75.15 ? 258 TYR A CZ 1 ATOM 2086 O OH . TYR A 1 258 ? 48.968 63.668 29.095 1.00 75.35 ? 258 TYR A OH 1 ATOM 2087 N N . SER A 1 259 ? 47.896 69.486 23.174 1.00 67.71 ? 259 SER A N 1 ATOM 2088 C CA . SER A 1 259 ? 47.344 70.551 22.349 1.00 65.94 ? 259 SER A CA 1 ATOM 2089 C C . SER A 1 259 ? 45.835 70.410 22.175 1.00 63.69 ? 259 SER A C 1 ATOM 2090 O O . SER A 1 259 ? 45.322 69.307 21.980 1.00 62.16 ? 259 SER A O 1 ATOM 2091 C CB . SER A 1 259 ? 48.015 70.545 20.976 1.00 66.22 ? 259 SER A CB 1 ATOM 2092 O OG . SER A 1 259 ? 49.417 70.690 21.105 1.00 69.74 ? 259 SER A OG 1 ATOM 2093 N N . CYS A 1 260 ? 45.127 71.533 22.246 1.00 61.36 ? 260 CYS A N 1 ATOM 2094 C CA . CYS A 1 260 ? 43.682 71.517 22.072 1.00 58.44 ? 260 CYS A CA 1 ATOM 2095 C C . CYS A 1 260 ? 43.324 71.656 20.605 1.00 55.81 ? 260 CYS A C 1 ATOM 2096 O O . CYS A 1 260 ? 43.994 72.368 19.856 1.00 56.59 ? 260 CYS A O 1 ATOM 2097 C CB . CYS A 1 260 ? 43.017 72.657 22.832 1.00 58.13 ? 260 CYS A CB 1 ATOM 2098 S SG . CYS A 1 260 ? 41.201 72.515 22.778 1.00 59.53 ? 260 CYS A SG 1 ATOM 2099 N N . HIS A 1 261 ? 42.254 70.985 20.200 1.00 52.99 ? 261 HIS A N 1 ATOM 2100 C CA . HIS A 1 261 ? 41.803 71.039 18.821 1.00 50.25 ? 261 HIS A CA 1 ATOM 2101 C C . HIS A 1 261 ? 40.354 71.498 18.751 1.00 49.00 ? 261 HIS A C 1 ATOM 2102 O O . HIS A 1 261 ? 39.482 70.957 19.437 1.00 47.27 ? 261 HIS A O 1 ATOM 2103 C CB . HIS A 1 261 ? 41.968 69.668 18.172 1.00 51.54 ? 261 HIS A CB 1 ATOM 2104 C CG . HIS A 1 261 ? 43.393 69.225 18.076 1.00 53.68 ? 261 HIS A CG 1 ATOM 2105 N ND1 . HIS A 1 261 ? 44.073 69.154 16.879 1.00 55.23 ? 261 HIS A ND1 1 ATOM 2106 C CD2 . HIS A 1 261 ? 44.283 68.878 19.036 1.00 54.35 ? 261 HIS A CD2 1 ATOM 2107 C CE1 . HIS A 1 261 ? 45.321 68.784 17.105 1.00 55.21 ? 261 HIS A CE1 1 ATOM 2108 N NE2 . HIS A 1 261 ? 45.475 68.610 18.406 1.00 55.20 ? 261 HIS A NE2 1 ATOM 2109 N N . VAL A 1 262 ? 40.107 72.509 17.924 1.00 45.28 ? 262 VAL A N 1 ATOM 2110 C CA . VAL A 1 262 ? 38.768 73.052 17.770 1.00 41.36 ? 262 VAL A CA 1 ATOM 2111 C C . VAL A 1 262 ? 38.365 73.145 16.312 1.00 42.04 ? 262 VAL A C 1 ATOM 2112 O O . VAL A 1 262 ? 39.046 73.785 15.507 1.00 42.62 ? 262 VAL A O 1 ATOM 2113 C CB . VAL A 1 262 ? 38.657 74.468 18.385 1.00 39.67 ? 262 VAL A CB 1 ATOM 2114 C CG1 . VAL A 1 262 ? 37.249 75.006 18.191 1.00 38.28 ? 262 VAL A CG1 1 ATOM 2115 C CG2 . VAL A 1 262 ? 39.009 74.432 19.860 1.00 37.72 ? 262 VAL A CG2 1 ATOM 2116 N N . GLN A 1 263 ? 37.262 72.492 15.972 1.00 40.99 ? 263 GLN A N 1 ATOM 2117 C CA . GLN A 1 263 ? 36.740 72.538 14.617 1.00 41.70 ? 263 GLN A CA 1 ATOM 2118 C C . GLN A 1 263 ? 35.337 73.103 14.731 1.00 41.14 ? 263 GLN A C 1 ATOM 2119 O O . GLN A 1 263 ? 34.573 72.722 15.626 1.00 40.75 ? 263 GLN A O 1 ATOM 2120 C CB . GLN A 1 263 ? 36.698 71.144 13.987 1.00 45.04 ? 263 GLN A CB 1 ATOM 2121 C CG . GLN A 1 263 ? 36.078 71.124 12.597 1.00 49.76 ? 263 GLN A CG 1 ATOM 2122 C CD . GLN A 1 263 ? 36.811 72.021 11.606 1.00 55.23 ? 263 GLN A CD 1 ATOM 2123 O OE1 . GLN A 1 263 ? 36.973 73.224 11.832 1.00 55.61 ? 263 GLN A OE1 1 ATOM 2124 N NE2 . GLN A 1 263 ? 37.252 71.435 10.493 1.00 56.96 ? 263 GLN A NE2 1 ATOM 2125 N N . HIS A 1 264 ? 35.002 74.020 13.835 1.00 40.15 ? 264 HIS A N 1 ATOM 2126 C CA . HIS A 1 264 ? 33.693 74.650 13.858 1.00 39.32 ? 264 HIS A CA 1 ATOM 2127 C C . HIS A 1 264 ? 33.284 75.058 12.453 1.00 40.61 ? 264 HIS A C 1 ATOM 2128 O O . HIS A 1 264 ? 34.129 75.311 11.596 1.00 42.03 ? 264 HIS A O 1 ATOM 2129 C CB . HIS A 1 264 ? 33.741 75.869 14.781 1.00 35.97 ? 264 HIS A CB 1 ATOM 2130 C CG . HIS A 1 264 ? 32.411 76.514 15.013 1.00 35.91 ? 264 HIS A CG 1 ATOM 2131 N ND1 . HIS A 1 264 ? 32.043 77.699 14.413 1.00 33.79 ? 264 HIS A ND1 1 ATOM 2132 C CD2 . HIS A 1 264 ? 31.371 76.151 15.801 1.00 33.96 ? 264 HIS A CD2 1 ATOM 2133 C CE1 . HIS A 1 264 ? 30.835 78.039 14.823 1.00 36.29 ? 264 HIS A CE1 1 ATOM 2134 N NE2 . HIS A 1 264 ? 30.404 77.115 15.666 1.00 32.94 ? 264 HIS A NE2 1 ATOM 2135 N N . SER A 1 265 ? 31.980 75.121 12.223 1.00 41.33 ? 265 SER A N 1 ATOM 2136 C CA . SER A 1 265 ? 31.442 75.485 10.921 1.00 42.29 ? 265 SER A CA 1 ATOM 2137 C C . SER A 1 265 ? 31.919 76.847 10.415 1.00 42.96 ? 265 SER A C 1 ATOM 2138 O O . SER A 1 265 ? 31.950 77.087 9.209 1.00 44.40 ? 265 SER A O 1 ATOM 2139 C CB . SER A 1 265 ? 29.916 75.472 10.983 1.00 41.68 ? 265 SER A CB 1 ATOM 2140 O OG . SER A 1 265 ? 29.456 76.321 12.023 1.00 43.32 ? 265 SER A OG 1 ATOM 2141 N N . SER A 1 266 ? 32.291 77.737 11.332 1.00 43.25 ? 266 SER A N 1 ATOM 2142 C CA . SER A 1 266 ? 32.742 79.077 10.960 1.00 42.36 ? 266 SER A CA 1 ATOM 2143 C C . SER A 1 266 ? 34.226 79.153 10.618 1.00 44.01 ? 266 SER A C 1 ATOM 2144 O O . SER A 1 266 ? 34.699 80.192 10.158 1.00 45.50 ? 266 SER A O 1 ATOM 2145 C CB . SER A 1 266 ? 32.478 80.054 12.099 1.00 40.23 ? 266 SER A CB 1 ATOM 2146 O OG . SER A 1 266 ? 33.384 79.811 13.164 1.00 35.84 ? 266 SER A OG 1 ATOM 2147 N N . LEU A 1 267 ? 34.955 78.067 10.856 1.00 43.90 ? 267 LEU A N 1 ATOM 2148 C CA . LEU A 1 267 ? 36.390 78.030 10.602 1.00 44.20 ? 267 LEU A CA 1 ATOM 2149 C C . LEU A 1 267 ? 36.753 77.422 9.256 1.00 46.20 ? 267 LEU A C 1 ATOM 2150 O O . LEU A 1 267 ? 36.234 76.373 8.882 1.00 45.78 ? 267 LEU A O 1 ATOM 2151 C CB . LEU A 1 267 ? 37.088 77.239 11.708 1.00 43.02 ? 267 LEU A CB 1 ATOM 2152 C CG . LEU A 1 267 ? 36.849 77.709 13.144 1.00 43.48 ? 267 LEU A CG 1 ATOM 2153 C CD1 . LEU A 1 267 ? 37.486 76.721 14.106 1.00 41.21 ? 267 LEU A CD1 1 ATOM 2154 C CD2 . LEU A 1 267 ? 37.419 79.116 13.344 1.00 42.03 ? 267 LEU A CD2 1 ATOM 2155 N N . ALA A 1 268 ? 37.655 78.081 8.535 1.00 47.49 ? 268 ALA A N 1 ATOM 2156 C CA . ALA A 1 268 ? 38.097 77.589 7.234 1.00 49.58 ? 268 ALA A CA 1 ATOM 2157 C C . ALA A 1 268 ? 38.750 76.227 7.437 1.00 49.26 ? 268 ALA A C 1 ATOM 2158 O O . ALA A 1 268 ? 38.628 75.337 6.603 1.00 49.54 ? 268 ALA A O 1 ATOM 2159 C CB . ALA A 1 268 ? 39.091 78.564 6.612 1.00 50.70 ? 268 ALA A CB 1 ATOM 2160 N N . GLN A 1 269 ? 39.456 76.087 8.553 1.00 49.52 ? 269 GLN A N 1 ATOM 2161 C CA . GLN A 1 269 ? 40.117 74.840 8.910 1.00 49.76 ? 269 GLN A CA 1 ATOM 2162 C C . GLN A 1 269 ? 40.216 74.808 10.426 1.00 49.09 ? 269 GLN A C 1 ATOM 2163 O O . GLN A 1 269 ? 40.105 75.840 11.080 1.00 48.10 ? 269 GLN A O 1 ATOM 2164 C CB . GLN A 1 269 ? 41.520 74.757 8.298 1.00 52.71 ? 269 GLN A CB 1 ATOM 2165 C CG . GLN A 1 269 ? 41.855 75.868 7.324 1.00 57.85 ? 269 GLN A CG 1 ATOM 2166 C CD . GLN A 1 269 ? 42.379 77.101 8.019 1.00 58.74 ? 269 GLN A CD 1 ATOM 2167 O OE1 . GLN A 1 269 ? 41.720 77.674 8.887 1.00 59.96 ? 269 GLN A OE1 1 ATOM 2168 N NE2 . GLN A 1 269 ? 43.580 77.515 7.643 1.00 60.64 ? 269 GLN A NE2 1 ATOM 2169 N N . PRO A 1 270 ? 40.427 73.620 11.006 1.00 49.08 ? 270 PRO A N 1 ATOM 2170 C CA . PRO A 1 270 ? 40.532 73.510 12.463 1.00 49.61 ? 270 PRO A CA 1 ATOM 2171 C C . PRO A 1 270 ? 41.677 74.307 13.075 1.00 49.70 ? 270 PRO A C 1 ATOM 2172 O O . PRO A 1 270 ? 42.673 74.602 12.414 1.00 50.40 ? 270 PRO A O 1 ATOM 2173 C CB . PRO A 1 270 ? 40.680 72.004 12.686 1.00 48.99 ? 270 PRO A CB 1 ATOM 2174 C CG . PRO A 1 270 ? 41.335 71.533 11.425 1.00 48.87 ? 270 PRO A CG 1 ATOM 2175 C CD . PRO A 1 270 ? 40.591 72.304 10.367 1.00 49.77 ? 270 PRO A CD 1 ATOM 2176 N N . LEU A 1 271 ? 41.511 74.662 14.345 1.00 49.05 ? 271 LEU A N 1 ATOM 2177 C CA . LEU A 1 271 ? 42.515 75.409 15.088 1.00 48.33 ? 271 LEU A CA 1 ATOM 2178 C C . LEU A 1 271 ? 43.179 74.484 16.095 1.00 48.35 ? 271 LEU A C 1 ATOM 2179 O O . LEU A 1 271 ? 42.563 73.538 16.588 1.00 48.18 ? 271 LEU A O 1 ATOM 2180 C CB . LEU A 1 271 ? 41.874 76.577 15.840 1.00 48.41 ? 271 LEU A CB 1 ATOM 2181 C CG . LEU A 1 271 ? 41.492 77.847 15.078 1.00 50.52 ? 271 LEU A CG 1 ATOM 2182 C CD1 . LEU A 1 271 ? 40.647 77.507 13.870 1.00 53.39 ? 271 LEU A CD1 1 ATOM 2183 C CD2 . LEU A 1 271 ? 40.739 78.777 16.012 1.00 51.32 ? 271 LEU A CD2 1 ATOM 2184 N N . VAL A 1 272 ? 44.440 74.759 16.397 1.00 47.53 ? 272 VAL A N 1 ATOM 2185 C CA . VAL A 1 272 ? 45.178 73.969 17.363 1.00 47.59 ? 272 VAL A CA 1 ATOM 2186 C C . VAL A 1 272 ? 45.792 74.935 18.363 1.00 49.11 ? 272 VAL A C 1 ATOM 2187 O O . VAL A 1 272 ? 46.295 75.995 17.989 1.00 49.14 ? 272 VAL A O 1 ATOM 2188 C CB . VAL A 1 272 ? 46.303 73.151 16.693 1.00 47.34 ? 272 VAL A CB 1 ATOM 2189 C CG1 . VAL A 1 272 ? 47.052 72.352 17.748 1.00 46.91 ? 272 VAL A CG1 1 ATOM 2190 C CG2 . VAL A 1 272 ? 45.723 72.223 15.633 1.00 44.98 ? 272 VAL A CG2 1 ATOM 2191 N N . VAL A 1 273 ? 45.735 74.574 19.637 1.00 50.62 ? 273 VAL A N 1 ATOM 2192 C CA . VAL A 1 273 ? 46.288 75.417 20.684 1.00 54.01 ? 273 VAL A CA 1 ATOM 2193 C C . VAL A 1 273 ? 47.072 74.577 21.675 1.00 57.09 ? 273 VAL A C 1 ATOM 2194 O O . VAL A 1 273 ? 46.517 74.078 22.653 1.00 58.16 ? 273 VAL A O 1 ATOM 2195 C CB . VAL A 1 273 ? 45.179 76.167 21.440 1.00 53.79 ? 273 VAL A CB 1 ATOM 2196 C CG1 . VAL A 1 273 ? 45.781 76.998 22.561 1.00 54.10 ? 273 VAL A CG1 1 ATOM 2197 C CG2 . VAL A 1 273 ? 44.412 77.049 20.476 1.00 53.71 ? 273 VAL A CG2 1 ATOM 2198 N N . PRO A 1 274 ? 48.381 74.406 21.432 1.00 59.86 ? 274 PRO A N 1 ATOM 2199 C CA . PRO A 1 274 ? 49.207 73.610 22.341 1.00 61.79 ? 274 PRO A CA 1 ATOM 2200 C C . PRO A 1 274 ? 49.306 74.262 23.714 1.00 63.85 ? 274 PRO A C 1 ATOM 2201 O O . PRO A 1 274 ? 49.125 75.472 23.850 1.00 63.54 ? 274 PRO A O 1 ATOM 2202 C CB . PRO A 1 274 ? 50.553 73.561 21.623 1.00 61.75 ? 274 PRO A CB 1 ATOM 2203 C CG . PRO A 1 274 ? 50.600 74.881 20.928 1.00 60.41 ? 274 PRO A CG 1 ATOM 2204 C CD . PRO A 1 274 ? 49.203 74.990 20.356 1.00 59.95 ? 274 PRO A CD 1 ATOM 2205 N N . TRP A 1 275 ? 49.579 73.450 24.729 1.00 66.60 ? 275 TRP A N 1 ATOM 2206 C CA . TRP A 1 275 ? 49.719 73.957 26.084 1.00 69.95 ? 275 TRP A CA 1 ATOM 2207 C C . TRP A 1 275 ? 51.202 74.012 26.433 1.00 72.56 ? 275 TRP A C 1 ATOM 2208 O O . TRP A 1 275 ? 51.912 73.011 26.319 1.00 71.88 ? 275 TRP A O 1 ATOM 2209 C CB . TRP A 1 275 ? 48.988 73.053 27.077 1.00 69.97 ? 275 TRP A CB 1 ATOM 2210 C CG . TRP A 1 275 ? 49.182 73.485 28.494 1.00 69.71 ? 275 TRP A CG 1 ATOM 2211 C CD1 . TRP A 1 275 ? 48.752 74.651 29.064 1.00 69.94 ? 275 TRP A CD1 1 ATOM 2212 C CD2 . TRP A 1 275 ? 49.906 72.784 29.509 1.00 69.45 ? 275 TRP A CD2 1 ATOM 2213 N NE1 . TRP A 1 275 ? 49.169 74.720 30.373 1.00 70.35 ? 275 TRP A NE1 1 ATOM 2214 C CE2 . TRP A 1 275 ? 49.880 73.587 30.671 1.00 69.73 ? 275 TRP A CE2 1 ATOM 2215 C CE3 . TRP A 1 275 ? 50.576 71.555 29.549 1.00 69.70 ? 275 TRP A CE3 1 ATOM 2216 C CZ2 . TRP A 1 275 ? 50.500 73.201 31.863 1.00 70.30 ? 275 TRP A CZ2 1 ATOM 2217 C CZ3 . TRP A 1 275 ? 51.194 71.170 30.736 1.00 71.01 ? 275 TRP A CZ3 1 ATOM 2218 C CH2 . TRP A 1 275 ? 51.151 71.993 31.877 1.00 71.08 ? 275 TRP A CH2 1 ATOM 2219 N N . GLU A 1 276 ? 51.664 75.185 26.854 1.00 75.72 ? 276 GLU A N 1 ATOM 2220 C CA . GLU A 1 276 ? 53.065 75.370 27.209 1.00 79.78 ? 276 GLU A CA 1 ATOM 2221 C C . GLU A 1 276 ? 53.276 75.332 28.716 1.00 81.30 ? 276 GLU A C 1 ATOM 2222 O O . GLU A 1 276 ? 53.028 76.316 29.414 1.00 81.79 ? 276 GLU A O 1 ATOM 2223 C CB . GLU A 1 276 ? 53.579 76.699 26.653 1.00 81.43 ? 276 GLU A CB 1 ATOM 2224 C CG . GLU A 1 276 ? 53.411 76.840 25.150 1.00 84.10 ? 276 GLU A CG 1 ATOM 2225 C CD . GLU A 1 276 ? 53.985 75.661 24.390 1.00 85.55 ? 276 GLU A CD 1 ATOM 2226 O OE1 . GLU A 1 276 ? 55.192 75.378 24.550 1.00 87.14 ? 276 GLU A OE1 1 ATOM 2227 O OE2 . GLU A 1 276 ? 53.230 75.017 23.632 1.00 86.48 ? 276 GLU A OE2 1 ATOM 2228 N N . ALA A 1 277 ? 53.738 74.187 29.210 1.00 82.71 ? 277 ALA A N 1 ATOM 2229 C CA . ALA A 1 277 ? 53.991 74.013 30.634 1.00 83.94 ? 277 ALA A CA 1 ATOM 2230 C C . ALA A 1 277 ? 55.080 74.977 31.101 1.00 84.77 ? 277 ALA A C 1 ATOM 2231 O O . ALA A 1 277 ? 55.599 75.735 30.253 1.00 85.28 ? 277 ALA A O 1 ATOM 2232 C CB . ALA A 1 277 ? 54.408 72.573 30.913 1.00 83.93 ? 277 ALA A CB 1 HETATM 2233 C C1 . NAG B 2 . ? 10.633 83.438 -0.020 1.00 81.38 ? 310 NAG A C1 1 HETATM 2234 C C2 . NAG B 2 . ? 9.626 84.494 0.455 1.00 81.37 ? 310 NAG A C2 1 HETATM 2235 C C3 . NAG B 2 . ? 9.389 85.533 -0.654 1.00 81.42 ? 310 NAG A C3 1 HETATM 2236 C C4 . NAG B 2 . ? 10.717 86.097 -1.167 1.00 81.82 ? 310 NAG A C4 1 HETATM 2237 C C5 . NAG B 2 . ? 11.645 84.944 -1.570 1.00 81.76 ? 310 NAG A C5 1 HETATM 2238 C C6 . NAG B 2 . ? 13.017 85.403 -2.023 1.00 82.25 ? 310 NAG A C6 1 HETATM 2239 C C7 . NAG B 2 . ? 7.405 83.721 -0.091 1.00 82.32 ? 310 NAG A C7 1 HETATM 2240 C C8 . NAG B 2 . ? 7.323 82.401 -0.842 1.00 81.90 ? 310 NAG A C8 1 HETATM 2241 N N2 . NAG B 2 . ? 8.373 83.855 0.812 1.00 81.27 ? 310 NAG A N2 1 HETATM 2242 O O3 . NAG B 2 . ? 8.578 86.591 -0.162 1.00 80.66 ? 310 NAG A O3 1 HETATM 2243 O O4 . NAG B 2 . ? 10.474 86.935 -2.288 1.00 82.36 ? 310 NAG A O4 1 HETATM 2244 O O5 . NAG B 2 . ? 11.848 84.064 -0.448 1.00 82.15 ? 310 NAG A O5 1 HETATM 2245 O O6 . NAG B 2 . ? 13.975 84.362 -1.879 1.00 81.12 ? 310 NAG A O6 1 HETATM 2246 O O7 . NAG B 2 . ? 6.597 84.615 -0.336 1.00 82.93 ? 310 NAG A O7 1 HETATM 2247 C C1 . NAG C 2 . ? 28.467 86.856 26.412 1.00 40.28 ? 320 NAG A C1 1 HETATM 2248 C C2 . NAG C 2 . ? 29.897 87.424 26.492 1.00 42.65 ? 320 NAG A C2 1 HETATM 2249 C C3 . NAG C 2 . ? 30.809 86.609 27.416 1.00 44.66 ? 320 NAG A C3 1 HETATM 2250 C C4 . NAG C 2 . ? 30.124 86.393 28.761 1.00 45.44 ? 320 NAG A C4 1 HETATM 2251 C C5 . NAG C 2 . ? 28.782 85.710 28.523 1.00 43.89 ? 320 NAG A C5 1 HETATM 2252 C C6 . NAG C 2 . ? 28.039 85.463 29.824 1.00 42.92 ? 320 NAG A C6 1 HETATM 2253 C C7 . NAG C 2 . ? 30.294 88.536 24.393 1.00 40.81 ? 320 NAG A C7 1 HETATM 2254 C C8 . NAG C 2 . ? 30.792 88.444 22.961 1.00 40.29 ? 320 NAG A C8 1 HETATM 2255 N N2 . NAG C 2 . ? 30.476 87.467 25.163 1.00 40.89 ? 320 NAG A N2 1 HETATM 2256 O O3 . NAG C 2 . ? 32.028 87.309 27.613 1.00 43.37 ? 320 NAG A O3 1 HETATM 2257 O O4 . NAG C 2 . ? 30.951 85.583 29.617 1.00 52.12 ? 320 NAG A O4 1 HETATM 2258 O O5 . NAG C 2 . ? 27.941 86.563 27.720 1.00 41.63 ? 320 NAG A O5 1 HETATM 2259 O O6 . NAG C 2 . ? 27.794 86.683 30.515 1.00 41.53 ? 320 NAG A O6 1 HETATM 2260 O O7 . NAG C 2 . ? 29.752 89.571 24.793 1.00 40.96 ? 320 NAG A O7 1 HETATM 2261 C C1 . NAG D 2 . ? 31.441 86.205 30.756 1.00 56.22 ? 321 NAG A C1 1 HETATM 2262 C C2 . NAG D 2 . ? 31.948 85.142 31.742 1.00 58.97 ? 321 NAG A C2 1 HETATM 2263 C C3 . NAG D 2 . ? 32.695 85.787 32.922 1.00 60.67 ? 321 NAG A C3 1 HETATM 2264 C C4 . NAG D 2 . ? 33.748 86.783 32.424 1.00 61.94 ? 321 NAG A C4 1 HETATM 2265 C C5 . NAG D 2 . ? 33.097 87.781 31.467 1.00 62.19 ? 321 NAG A C5 1 HETATM 2266 C C6 . NAG D 2 . ? 34.086 88.781 30.896 1.00 62.86 ? 321 NAG A C6 1 HETATM 2267 C C7 . NAG D 2 . ? 30.899 83.047 32.302 1.00 60.33 ? 321 NAG A C7 1 HETATM 2268 C C8 . NAG D 2 . ? 31.045 82.420 33.679 1.00 61.95 ? 321 NAG A C8 1 HETATM 2269 N N2 . NAG D 2 . ? 30.824 84.372 32.240 1.00 58.36 ? 321 NAG A N2 1 HETATM 2270 O O3 . NAG D 2 . ? 33.331 84.776 33.692 1.00 60.18 ? 321 NAG A O3 1 HETATM 2271 O O4 . NAG D 2 . ? 34.316 87.476 33.528 1.00 64.39 ? 321 NAG A O4 1 HETATM 2272 O O5 . NAG D 2 . ? 32.509 87.074 30.354 1.00 60.17 ? 321 NAG A O5 1 HETATM 2273 O O6 . NAG D 2 . ? 34.780 88.238 29.781 1.00 63.39 ? 321 NAG A O6 1 HETATM 2274 O O7 . NAG D 2 . ? 30.862 82.329 31.303 1.00 61.38 ? 321 NAG A O7 1 HETATM 2275 O O . HOH E 3 . ? 0.589 70.454 32.009 1.00 19.99 ? 322 HOH A O 1 HETATM 2276 O O . HOH E 3 . ? 6.303 75.425 31.122 1.00 23.57 ? 323 HOH A O 1 HETATM 2277 O O . HOH E 3 . ? -0.988 70.432 16.353 1.00 24.13 ? 324 HOH A O 1 HETATM 2278 O O . HOH E 3 . ? 5.968 79.206 29.240 1.00 24.30 ? 325 HOH A O 1 HETATM 2279 O O . HOH E 3 . ? -10.721 77.090 17.005 1.00 28.00 ? 326 HOH A O 1 HETATM 2280 O O . HOH E 3 . ? -1.260 75.661 40.483 1.00 29.70 ? 327 HOH A O 1 HETATM 2281 O O . HOH E 3 . ? 0.080 64.694 19.701 1.00 32.90 ? 328 HOH A O 1 HETATM 2282 O O . HOH E 3 . ? 6.155 90.679 31.534 1.00 31.49 ? 329 HOH A O 1 HETATM 2283 O O . HOH E 3 . ? -15.184 76.242 14.287 1.00 33.73 ? 330 HOH A O 1 HETATM 2284 O O . HOH E 3 . ? -7.221 64.843 33.651 1.00 33.28 ? 331 HOH A O 1 HETATM 2285 O O . HOH E 3 . ? -16.452 68.189 21.560 1.00 33.33 ? 332 HOH A O 1 HETATM 2286 O O . HOH E 3 . ? 17.906 88.935 27.773 1.00 34.35 ? 333 HOH A O 1 HETATM 2287 O O . HOH E 3 . ? 14.792 78.938 23.694 1.00 34.22 ? 334 HOH A O 1 HETATM 2288 O O . HOH E 3 . ? 11.956 77.811 17.982 1.00 29.85 ? 335 HOH A O 1 HETATM 2289 O O . HOH E 3 . ? 23.023 76.731 17.475 1.00 32.97 ? 336 HOH A O 1 HETATM 2290 O O . HOH E 3 . ? 3.044 80.342 35.253 1.00 28.99 ? 337 HOH A O 1 HETATM 2291 O O . HOH E 3 . ? -2.435 71.171 12.902 1.00 32.12 ? 338 HOH A O 1 HETATM 2292 O O . HOH E 3 . ? 0.166 86.289 38.658 1.00 32.92 ? 339 HOH A O 1 HETATM 2293 O O . HOH E 3 . ? 22.980 85.169 28.958 1.00 35.15 ? 340 HOH A O 1 HETATM 2294 O O . HOH E 3 . ? -17.613 79.384 22.538 1.00 40.28 ? 341 HOH A O 1 HETATM 2295 O O . HOH E 3 . ? 28.175 73.940 22.101 1.00 43.00 ? 342 HOH A O 1 HETATM 2296 O O . HOH E 3 . ? -0.426 62.212 27.758 1.00 33.07 ? 343 HOH A O 1 HETATM 2297 O O . HOH E 3 . ? 5.793 87.146 18.561 1.00 37.35 ? 344 HOH A O 1 HETATM 2298 O O . HOH E 3 . ? 18.297 86.000 27.667 1.00 40.12 ? 345 HOH A O 1 HETATM 2299 O O . HOH E 3 . ? -11.648 82.518 17.440 1.00 35.82 ? 346 HOH A O 1 HETATM 2300 O O . HOH E 3 . ? 29.744 71.383 22.804 1.00 44.56 ? 347 HOH A O 1 HETATM 2301 O O . HOH E 3 . ? 20.135 79.512 13.957 1.00 33.04 ? 348 HOH A O 1 HETATM 2302 O O . HOH E 3 . ? -13.121 71.931 30.096 1.00 32.37 ? 349 HOH A O 1 HETATM 2303 O O . HOH E 3 . ? 5.808 88.354 6.564 1.00 42.41 ? 350 HOH A O 1 HETATM 2304 O O . HOH E 3 . ? 4.365 65.220 31.486 1.00 32.94 ? 351 HOH A O 1 HETATM 2305 O O . HOH E 3 . ? -5.985 62.861 30.685 1.00 50.27 ? 352 HOH A O 1 HETATM 2306 O O . HOH E 3 . ? 28.228 75.110 14.180 1.00 43.88 ? 353 HOH A O 1 HETATM 2307 O O . HOH E 3 . ? 2.571 76.437 8.697 1.00 35.85 ? 354 HOH A O 1 HETATM 2308 O O . HOH E 3 . ? 5.598 88.095 21.360 1.00 39.95 ? 355 HOH A O 1 HETATM 2309 O O . HOH E 3 . ? 21.087 82.475 29.208 1.00 35.25 ? 356 HOH A O 1 HETATM 2310 O O . HOH E 3 . ? 29.977 69.160 25.736 1.00 52.95 ? 357 HOH A O 1 HETATM 2311 O O . HOH E 3 . ? -11.349 78.472 26.654 1.00 40.64 ? 358 HOH A O 1 HETATM 2312 O O . HOH E 3 . ? -4.967 65.937 37.148 1.00 38.01 ? 359 HOH A O 1 HETATM 2313 O O . HOH E 3 . ? 9.287 73.536 21.746 1.00 53.76 ? 360 HOH A O 1 HETATM 2314 O O . HOH E 3 . ? 2.662 84.264 16.460 1.00 47.20 ? 361 HOH A O 1 HETATM 2315 O O . HOH E 3 . ? 0.596 62.222 36.703 1.00 51.42 ? 362 HOH A O 1 HETATM 2316 O O . HOH E 3 . ? 23.913 80.248 11.831 1.00 35.00 ? 363 HOH A O 1 HETATM 2317 O O . HOH E 3 . ? 4.642 84.260 4.834 1.00 41.06 ? 364 HOH A O 1 HETATM 2318 O O . HOH E 3 . ? 0.061 68.159 17.943 1.00 37.77 ? 365 HOH A O 1 HETATM 2319 O O . HOH E 3 . ? -5.541 85.617 19.953 1.00 50.08 ? 366 HOH A O 1 HETATM 2320 O O . HOH E 3 . ? -4.438 62.571 28.127 1.00 38.75 ? 367 HOH A O 1 HETATM 2321 O O . HOH E 3 . ? -0.495 76.072 45.006 1.00 46.71 ? 368 HOH A O 1 HETATM 2322 O O . HOH E 3 . ? -3.236 81.154 40.091 1.00 39.76 ? 369 HOH A O 1 HETATM 2323 O O . HOH E 3 . ? 32.840 70.304 25.620 1.00 47.82 ? 370 HOH A O 1 HETATM 2324 O O . HOH E 3 . ? 1.804 73.382 41.600 1.00 35.36 ? 371 HOH A O 1 HETATM 2325 O O . HOH E 3 . ? 1.708 83.557 5.225 1.00 44.28 ? 372 HOH A O 1 HETATM 2326 O O . HOH E 3 . ? -6.451 83.412 12.637 1.00 36.53 ? 373 HOH A O 1 HETATM 2327 O O . HOH E 3 . ? -10.590 61.582 23.150 1.00 44.43 ? 374 HOH A O 1 HETATM 2328 O O . HOH E 3 . ? 2.490 64.605 27.090 1.00 39.33 ? 375 HOH A O 1 HETATM 2329 O O . HOH E 3 . ? -7.615 67.831 37.707 1.00 49.56 ? 376 HOH A O 1 HETATM 2330 O O . HOH E 3 . ? -1.747 63.983 5.195 1.00 46.63 ? 377 HOH A O 1 HETATM 2331 O O . HOH E 3 . ? -19.774 73.638 19.396 1.00 51.07 ? 378 HOH A O 1 HETATM 2332 O O . HOH E 3 . ? 25.224 86.803 27.717 1.00 36.99 ? 379 HOH A O 1 HETATM 2333 O O . HOH E 3 . ? 12.208 86.402 5.552 1.00 45.41 ? 380 HOH A O 1 HETATM 2334 O O . HOH E 3 . ? 29.805 87.057 19.285 1.00 55.14 ? 381 HOH A O 1 HETATM 2335 O O . HOH E 3 . ? 34.622 74.617 34.393 1.00 59.35 ? 382 HOH A O 1 HETATM 2336 O O . HOH E 3 . ? -18.700 81.630 20.862 1.00 52.94 ? 383 HOH A O 1 HETATM 2337 O O . HOH E 3 . ? 30.315 83.360 25.368 1.00 39.32 ? 384 HOH A O 1 HETATM 2338 O O . HOH E 3 . ? -19.166 64.550 32.501 1.00 52.24 ? 385 HOH A O 1 HETATM 2339 O O . HOH E 3 . ? 26.932 88.225 20.583 1.00 44.55 ? 386 HOH A O 1 HETATM 2340 O O . HOH E 3 . ? -15.449 72.670 31.669 1.00 48.07 ? 387 HOH A O 1 HETATM 2341 O O . HOH E 3 . ? 12.044 95.537 17.414 1.00 50.24 ? 388 HOH A O 1 HETATM 2342 O O . HOH E 3 . ? -15.010 62.598 33.207 1.00 52.35 ? 389 HOH A O 1 HETATM 2343 O O . HOH E 3 . ? 4.840 78.000 1.547 1.00 48.68 ? 390 HOH A O 1 HETATM 2344 O O . HOH E 3 . ? -14.189 71.320 11.508 1.00 43.19 ? 391 HOH A O 1 HETATM 2345 O O . HOH E 3 . ? -1.168 86.318 13.937 1.00 43.33 ? 392 HOH A O 1 HETATM 2346 O O . HOH E 3 . ? 40.457 77.207 29.712 1.00 48.13 ? 393 HOH A O 1 HETATM 2347 O O . HOH E 3 . ? 2.340 80.698 4.058 1.00 47.78 ? 394 HOH A O 1 HETATM 2348 O O . HOH E 3 . ? -8.363 79.161 7.185 1.00 31.90 ? 395 HOH A O 1 HETATM 2349 O O . HOH E 3 . ? 12.991 93.628 19.651 1.00 52.13 ? 396 HOH A O 1 HETATM 2350 O O . HOH E 3 . ? 0.946 98.037 26.319 1.00 64.62 ? 397 HOH A O 1 HETATM 2351 O O . HOH E 3 . ? 5.422 77.431 8.456 1.00 42.55 ? 398 HOH A O 1 HETATM 2352 O O . HOH E 3 . ? -12.928 76.428 28.215 1.00 45.92 ? 399 HOH A O 1 HETATM 2353 O O . HOH E 3 . ? -4.318 65.378 33.570 1.00 47.06 ? 400 HOH A O 1 HETATM 2354 O O . HOH E 3 . ? -7.350 69.501 4.242 1.00 44.10 ? 401 HOH A O 1 HETATM 2355 O O . HOH E 3 . ? 30.411 73.055 13.536 1.00 45.01 ? 402 HOH A O 1 HETATM 2356 O O . HOH E 3 . ? 9.913 73.869 18.613 1.00 49.36 ? 403 HOH A O 1 HETATM 2357 O O . HOH E 3 . ? 27.114 71.123 30.498 1.00 48.23 ? 404 HOH A O 1 HETATM 2358 O O . HOH E 3 . ? 2.887 87.857 19.111 1.00 41.15 ? 405 HOH A O 1 HETATM 2359 O O . HOH E 3 . ? -3.062 69.386 43.441 1.00 53.81 ? 406 HOH A O 1 HETATM 2360 O O . HOH E 3 . ? 13.721 93.705 27.312 1.00 56.66 ? 407 HOH A O 1 HETATM 2361 O O . HOH E 3 . ? -9.158 84.660 32.465 1.00 39.53 ? 408 HOH A O 1 HETATM 2362 O O . HOH E 3 . ? 1.749 91.775 18.324 1.00 49.38 ? 409 HOH A O 1 HETATM 2363 O O . HOH E 3 . ? -7.675 83.156 5.751 1.00 59.31 ? 410 HOH A O 1 HETATM 2364 O O . HOH E 3 . ? -4.761 89.684 31.297 1.00 60.31 ? 411 HOH A O 1 HETATM 2365 O O . HOH E 3 . ? -6.919 75.345 41.611 1.00 42.46 ? 412 HOH A O 1 HETATM 2366 O O . HOH E 3 . ? -5.603 93.286 25.670 1.00 49.72 ? 413 HOH A O 1 HETATM 2367 O O . HOH E 3 . ? 4.089 84.633 -0.095 1.00 59.39 ? 414 HOH A O 1 HETATM 2368 O O . HOH E 3 . ? -2.275 69.913 7.318 1.00 66.02 ? 415 HOH A O 1 HETATM 2369 O O . HOH E 3 . ? 41.307 82.532 20.486 1.00 43.50 ? 416 HOH A O 1 HETATM 2370 O O . HOH E 3 . ? 24.537 73.939 15.275 1.00 59.77 ? 417 HOH A O 1 HETATM 2371 O O . HOH E 3 . ? 28.557 69.955 19.390 1.00 41.78 ? 418 HOH A O 1 HETATM 2372 O O . HOH E 3 . ? 38.798 80.640 9.363 1.00 60.38 ? 419 HOH A O 1 HETATM 2373 O O . HOH E 3 . ? 1.605 85.200 13.820 1.00 51.00 ? 420 HOH A O 1 HETATM 2374 O O . HOH E 3 . ? 26.995 90.399 26.676 1.00 46.84 ? 421 HOH A O 1 HETATM 2375 O O . HOH E 3 . ? 36.334 84.621 18.725 1.00 42.84 ? 422 HOH A O 1 HETATM 2376 O O . HOH E 3 . ? 24.140 83.259 30.786 1.00 50.14 ? 423 HOH A O 1 HETATM 2377 O O . HOH E 3 . ? 20.831 79.657 9.771 1.00 48.78 ? 424 HOH A O 1 HETATM 2378 O O . HOH E 3 . ? -2.242 94.063 20.223 1.00 66.55 ? 425 HOH A O 1 HETATM 2379 O O . HOH E 3 . ? 28.400 86.138 11.065 1.00 54.44 ? 426 HOH A O 1 HETATM 2380 O O . HOH E 3 . ? 3.482 70.313 21.150 1.00 53.72 ? 427 HOH A O 1 HETATM 2381 O O . HOH E 3 . ? 39.575 65.643 24.719 1.00 50.51 ? 428 HOH A O 1 HETATM 2382 O O . HOH E 3 . ? -9.245 89.956 27.524 1.00 55.00 ? 429 HOH A O 1 HETATM 2383 O O . HOH E 3 . ? -3.436 86.483 17.138 1.00 49.50 ? 430 HOH A O 1 HETATM 2384 O O . HOH E 3 . ? 51.972 71.029 22.913 1.00 63.85 ? 431 HOH A O 1 HETATM 2385 O O . HOH E 3 . ? 8.818 90.537 32.980 1.00 51.50 ? 432 HOH A O 1 HETATM 2386 O O . HOH E 3 . ? 18.746 77.283 -0.774 1.00 63.55 ? 433 HOH A O 1 HETATM 2387 O O . HOH E 3 . ? -8.087 66.324 40.329 1.00 49.42 ? 434 HOH A O 1 HETATM 2388 O O . HOH E 3 . ? -21.655 80.983 19.729 1.00 54.26 ? 435 HOH A O 1 HETATM 2389 O O . HOH E 3 . ? 14.975 76.902 21.393 1.00 40.17 ? 436 HOH A O 1 HETATM 2390 O O . HOH E 3 . ? -17.204 70.681 18.326 1.00 39.79 ? 437 HOH A O 1 HETATM 2391 O O . HOH E 3 . ? 2.047 85.251 20.665 1.00 50.53 ? 438 HOH A O 1 HETATM 2392 O O . HOH E 3 . ? -14.588 88.512 16.577 1.00 52.06 ? 439 HOH A O 1 HETATM 2393 O O . HOH E 3 . ? -2.816 81.605 44.330 1.00 43.18 ? 440 HOH A O 1 HETATM 2394 O O . HOH E 3 . ? 1.425 61.258 24.898 1.00 52.65 ? 441 HOH A O 1 HETATM 2395 O O . HOH E 3 . ? -23.335 78.425 14.197 1.00 52.10 ? 442 HOH A O 1 HETATM 2396 O O . HOH E 3 . ? 38.344 87.252 24.760 1.00 52.92 ? 443 HOH A O 1 HETATM 2397 O O . HOH E 3 . ? 5.251 78.385 35.604 1.00 35.93 ? 444 HOH A O 1 HETATM 2398 O O . HOH E 3 . ? 24.451 73.371 27.672 1.00 58.80 ? 445 HOH A O 1 HETATM 2399 O O . HOH E 3 . ? 32.942 85.203 17.659 1.00 47.63 ? 446 HOH A O 1 HETATM 2400 O O . HOH E 3 . ? 21.304 74.889 23.139 1.00 44.40 ? 447 HOH A O 1 HETATM 2401 O O . HOH E 3 . ? 0.517 81.934 48.437 1.00 68.09 ? 448 HOH A O 1 HETATM 2402 O O . HOH E 3 . ? -17.031 75.244 31.297 1.00 65.53 ? 449 HOH A O 1 HETATM 2403 O O . HOH E 3 . ? -18.769 73.651 25.777 1.00 57.84 ? 450 HOH A O 1 HETATM 2404 O O . HOH E 3 . ? 32.144 84.509 9.697 1.00 66.54 ? 451 HOH A O 1 HETATM 2405 O O . HOH E 3 . ? 42.163 62.729 31.194 1.00 52.86 ? 452 HOH A O 1 HETATM 2406 O O . HOH E 3 . ? -9.719 62.156 33.209 1.00 50.75 ? 453 HOH A O 1 HETATM 2407 O O . HOH E 3 . ? 36.142 86.640 22.152 1.00 52.40 ? 454 HOH A O 1 HETATM 2408 O O . HOH E 3 . ? 6.599 68.755 9.951 1.00 47.06 ? 455 HOH A O 1 HETATM 2409 O O . HOH E 3 . ? 0.515 86.115 17.903 1.00 68.89 ? 456 HOH A O 1 HETATM 2410 O O . HOH E 3 . ? -15.750 69.393 13.137 1.00 33.57 ? 457 HOH A O 1 HETATM 2411 O O . HOH E 3 . ? 38.375 84.175 16.365 0.50 57.27 ? 458 HOH A O 1 HETATM 2412 O O . HOH E 3 . ? 13.466 74.633 24.357 1.00 48.32 ? 459 HOH A O 1 HETATM 2413 O O . HOH E 3 . ? 8.200 83.686 30.432 1.00 28.58 ? 460 HOH A O 1 HETATM 2414 O O . HOH E 3 . ? 23.523 73.639 24.837 1.00 59.63 ? 461 HOH A O 1 HETATM 2415 O O . HOH E 3 . ? 2.987 68.443 18.733 1.00 57.62 ? 462 HOH A O 1 HETATM 2416 O O . HOH E 3 . ? -16.107 73.726 13.080 1.00 35.16 ? 463 HOH A O 1 HETATM 2417 O O . HOH E 3 . ? -18.633 81.712 11.572 1.00 31.96 ? 464 HOH A O 1 HETATM 2418 O O . HOH E 3 . ? 0.286 68.917 14.222 1.00 47.67 ? 465 HOH A O 1 HETATM 2419 O O . HOH E 3 . ? 25.286 72.580 22.483 1.00 53.55 ? 466 HOH A O 1 HETATM 2420 O O . HOH E 3 . ? 14.692 76.874 25.933 1.00 43.21 ? 467 HOH A O 1 HETATM 2421 O O . HOH E 3 . ? -11.241 74.264 29.327 1.00 51.46 ? 468 HOH A O 1 HETATM 2422 O O . HOH E 3 . ? 21.391 71.328 25.379 1.00 39.17 ? 469 HOH A O 1 HETATM 2423 O O . HOH E 3 . ? 1.468 63.824 33.745 1.00 35.90 ? 470 HOH A O 1 HETATM 2424 O O . HOH E 3 . ? 23.047 80.390 30.826 1.00 42.80 ? 471 HOH A O 1 HETATM 2425 O O . HOH E 3 . ? -4.827 92.702 21.397 1.00 53.21 ? 472 HOH A O 1 HETATM 2426 O O . HOH E 3 . ? 11.168 83.109 30.145 1.00 43.93 ? 473 HOH A O 1 HETATM 2427 O O . HOH E 3 . ? -15.365 72.576 9.063 1.00 59.36 ? 474 HOH A O 1 HETATM 2428 O O . HOH E 3 . ? 2.709 73.605 7.616 1.00 57.99 ? 475 HOH A O 1 HETATM 2429 O O . HOH E 3 . ? 23.387 69.241 26.426 1.00 51.58 ? 476 HOH A O 1 HETATM 2430 O O . HOH E 3 . ? 5.861 63.279 29.832 1.00 45.78 ? 477 HOH A O 1 HETATM 2431 O O . HOH E 3 . ? -7.989 64.863 36.553 1.00 47.79 ? 478 HOH A O 1 HETATM 2432 O O . HOH E 3 . ? 20.615 86.503 30.430 1.00 63.93 ? 479 HOH A O 1 HETATM 2433 O O . HOH E 3 . ? 34.789 87.238 19.445 1.00 61.62 ? 480 HOH A O 1 HETATM 2434 O O . HOH E 3 . ? -8.343 71.685 6.085 1.00 60.16 ? 481 HOH A O 1 HETATM 2435 O O . HOH E 3 . ? 10.080 78.409 23.057 1.00 53.90 ? 482 HOH A O 1 HETATM 2436 O O . HOH E 3 . ? -20.210 77.900 23.726 1.00 55.27 ? 483 HOH A O 1 HETATM 2437 O O . HOH E 3 . ? 0.361 63.419 39.659 1.00 50.21 ? 484 HOH A O 1 HETATM 2438 O O . HOH E 3 . ? 14.117 79.146 4.911 1.00 59.84 ? 485 HOH A O 1 HETATM 2439 O O . HOH E 3 . ? 0.314 70.804 11.739 1.00 49.03 ? 486 HOH A O 1 HETATM 2440 O O . HOH E 3 . ? 9.406 73.178 15.235 1.00 52.83 ? 487 HOH A O 1 HETATM 2441 O O . HOH E 3 . ? -9.168 87.433 25.683 1.00 59.51 ? 488 HOH A O 1 HETATM 2442 O O . HOH E 3 . ? 39.158 79.595 31.194 1.00 55.57 ? 489 HOH A O 1 HETATM 2443 O O . HOH E 3 . ? -10.390 82.856 34.609 1.00 63.71 ? 490 HOH A O 1 HETATM 2444 O O . HOH E 3 . ? 11.973 83.454 4.814 1.00 60.62 ? 491 HOH A O 1 HETATM 2445 O O . HOH E 3 . ? 36.621 82.140 11.103 1.00 60.70 ? 492 HOH A O 1 HETATM 2446 O O . HOH E 3 . ? 17.584 94.263 11.955 1.00 60.49 ? 493 HOH A O 1 HETATM 2447 O O . HOH E 3 . ? 7.658 88.078 -2.227 1.00 67.92 ? 494 HOH A O 1 HETATM 2448 O O . HOH E 3 . ? 18.314 73.457 3.932 1.00 67.28 ? 495 HOH A O 1 HETATM 2449 O O . HOH E 3 . ? 4.503 69.503 12.384 1.00 56.90 ? 496 HOH A O 1 HETATM 2450 O O . HOH E 3 . ? -12.469 80.795 20.032 1.00 66.87 ? 497 HOH A O 1 HETATM 2451 O O . HOH E 3 . ? 33.817 81.905 30.525 1.00 66.92 ? 498 HOH A O 1 HETATM 2452 O O . HOH E 3 . ? 28.180 67.341 17.615 1.00 62.10 ? 499 HOH A O 1 HETATM 2453 O O . HOH E 3 . ? 6.063 69.528 17.145 1.00 81.11 ? 500 HOH A O 1 HETATM 2454 O O . HOH E 3 . ? 33.499 67.982 23.377 1.00 73.65 ? 501 HOH A O 1 HETATM 2455 O O . HOH E 3 . ? 40.356 82.099 17.465 1.00 63.64 ? 502 HOH A O 1 HETATM 2456 O O . HOH E 3 . ? 11.477 75.810 22.258 1.00 53.33 ? 503 HOH A O 1 HETATM 2457 O O . HOH E 3 . ? 8.595 98.661 21.104 1.00 44.64 ? 504 HOH A O 1 HETATM 2458 O O . HOH E 3 . ? 24.070 89.905 27.924 1.00 50.32 ? 505 HOH A O 1 HETATM 2459 O O . HOH E 3 . ? -10.726 73.842 5.322 1.00 62.60 ? 506 HOH A O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 GLN 1 1 ? ? ? A . n A 1 2 GLU 2 2 ? ? ? A . n A 1 3 ASN 3 3 ? ? ? A . n A 1 4 GLN 4 4 ? ? ? A . n A 1 5 ASP 5 5 5 ASP ASP A . n A 1 6 GLY 6 6 6 GLY GLY A . n A 1 7 ARG 7 7 7 ARG ARG A . n A 1 8 TYR 8 8 8 TYR TYR A . n A 1 9 SER 9 9 9 SER SER A . n A 1 10 LEU 10 10 10 LEU LEU A . n A 1 11 THR 11 11 11 THR THR A . n A 1 12 TYR 12 12 12 TYR TYR A . n A 1 13 ILE 13 13 13 ILE ILE A . n A 1 14 TYR 14 14 14 TYR TYR A . n A 1 15 THR 15 15 15 THR THR A . n A 1 16 GLY 16 16 16 GLY GLY A . n A 1 17 LEU 17 17 17 LEU LEU A . n A 1 18 SER 18 18 18 SER SER A . n A 1 19 LYS 19 19 19 LYS LYS A . n A 1 20 HIS 20 20 20 HIS HIS A . n A 1 21 VAL 21 21 21 VAL VAL A . n A 1 22 GLU 22 22 22 GLU GLU A . n A 1 23 ASP 23 23 23 ASP ASP A . n A 1 24 VAL 24 24 24 VAL VAL A . n A 1 25 PRO 25 25 25 PRO PRO A . n A 1 26 ALA 26 26 26 ALA ALA A . n A 1 27 PHE 27 27 27 PHE PHE A . n A 1 28 GLN 28 28 28 GLN GLN A . n A 1 29 ALA 29 29 29 ALA ALA A . n A 1 30 LEU 30 30 30 LEU LEU A . n A 1 31 GLY 31 31 31 GLY GLY A . n A 1 32 SER 32 32 32 SER SER A . n A 1 33 LEU 33 33 33 LEU LEU A . n A 1 34 ASN 34 34 34 ASN ASN A . n A 1 35 ASP 35 35 35 ASP ASP A . n A 1 36 LEU 36 36 36 LEU LEU A . n A 1 37 GLN 37 37 37 GLN GLN A . n A 1 38 PHE 38 38 38 PHE PHE A . n A 1 39 PHE 39 39 39 PHE PHE A . n A 1 40 ARG 40 40 40 ARG ARG A . n A 1 41 TYR 41 41 41 TYR TYR A . n A 1 42 ASN 42 42 42 ASN ASN A . n A 1 43 SER 43 43 43 SER SER A . n A 1 44 LYS 44 44 44 LYS LYS A . n A 1 45 ASP 45 45 45 ASP ASP A . n A 1 46 ARG 46 46 46 ARG ARG A . n A 1 47 LYS 47 47 47 LYS LYS A . n A 1 48 SER 48 48 48 SER SER A . n A 1 49 GLN 49 49 49 GLN GLN A . n A 1 50 PRO 50 50 50 PRO PRO A . n A 1 51 MET 51 51 51 MET MET A . n A 1 52 GLY 52 52 52 GLY GLY A . n A 1 53 LEU 53 53 53 LEU LEU A . n A 1 54 TRP 54 54 54 TRP TRP A . n A 1 55 ARG 55 55 55 ARG ARG A . n A 1 56 GLN 56 56 56 GLN GLN A . n A 1 57 VAL 57 57 57 VAL VAL A . n A 1 58 GLU 58 58 58 GLU GLU A . n A 1 59 GLY 59 59 59 GLY GLY A . n A 1 60 MET 60 60 60 MET MET A . n A 1 61 GLU 61 61 61 GLU GLU A . n A 1 62 ASP 62 62 62 ASP ASP A . n A 1 63 TRP 63 63 63 TRP TRP A . n A 1 64 LYS 64 64 64 LYS LYS A . n A 1 65 GLN 65 65 65 GLN GLN A . n A 1 66 ASP 66 66 66 ASP ASP A . n A 1 67 SER 67 67 67 SER SER A . n A 1 68 GLN 68 68 68 GLN GLN A . n A 1 69 LEU 69 69 69 LEU LEU A . n A 1 70 GLN 70 70 70 GLN GLN A . n A 1 71 LYS 71 71 71 LYS LYS A . n A 1 72 ALA 72 72 72 ALA ALA A . n A 1 73 ARG 73 73 73 ARG ARG A . n A 1 74 GLU 74 74 74 GLU GLU A . n A 1 75 ASP 75 75 75 ASP ASP A . n A 1 76 ILE 76 76 76 ILE ILE A . n A 1 77 PHE 77 77 77 PHE PHE A . n A 1 78 MET 78 78 78 MET MET A . n A 1 79 GLU 79 79 79 GLU GLU A . n A 1 80 THR 80 80 80 THR THR A . n A 1 81 LEU 81 81 81 LEU LEU A . n A 1 82 LYS 82 82 82 LYS LYS A . n A 1 83 ASP 83 83 83 ASP ASP A . n A 1 84 ILE 84 84 84 ILE ILE A . n A 1 85 VAL 85 85 85 VAL VAL A . n A 1 86 GLU 86 86 86 GLU GLU A . n A 1 87 TYR 87 87 87 TYR TYR A . n A 1 88 TYR 88 88 88 TYR TYR A . n A 1 89 LYS 89 89 89 LYS LYS A . n A 1 90 ASP 90 90 90 ASP ASP A . n A 1 91 SER 91 91 91 SER SER A . n A 1 92 THR 92 92 92 THR THR A . n A 1 93 GLY 93 93 93 GLY GLY A . n A 1 94 SER 94 94 94 SER SER A . n A 1 95 HIS 95 95 95 HIS HIS A . n A 1 96 VAL 96 96 96 VAL VAL A . n A 1 97 LEU 97 97 97 LEU LEU A . n A 1 98 GLN 98 98 98 GLN GLN A . n A 1 99 GLY 99 99 99 GLY GLY A . n A 1 100 ARG 100 100 100 ARG ARG A . n A 1 101 PHE 101 101 101 PHE PHE A . n A 1 102 GLY 102 102 102 GLY GLY A . n A 1 103 CYS 103 103 103 CYS CYS A . n A 1 104 GLU 104 104 104 GLU GLU A . n A 1 105 ILE 105 105 105 ILE ILE A . n A 1 106 GLU 106 106 106 GLU GLU A . n A 1 107 ASN 107 107 107 ASN ASN A . n A 1 108 ASN 108 108 108 ASN ASN A . n A 1 109 ARG 109 109 109 ARG ARG A . n A 1 110 SER 110 110 110 SER SER A . n A 1 111 SER 111 111 111 SER SER A . n A 1 112 GLY 112 112 112 GLY GLY A . n A 1 113 ALA 113 113 113 ALA ALA A . n A 1 114 PHE 114 114 114 PHE PHE A . n A 1 115 TRP 115 115 115 TRP TRP A . n A 1 116 LYS 116 116 116 LYS LYS A . n A 1 117 TYR 117 117 117 TYR TYR A . n A 1 118 TYR 118 118 118 TYR TYR A . n A 1 119 TYR 119 119 119 TYR TYR A . n A 1 120 ASP 120 120 120 ASP ASP A . n A 1 121 GLY 121 121 121 GLY GLY A . n A 1 122 LYS 122 122 122 LYS LYS A . n A 1 123 ASP 123 123 123 ASP ASP A . n A 1 124 TYR 124 124 124 TYR TYR A . n A 1 125 ILE 125 125 125 ILE ILE A . n A 1 126 GLU 126 126 126 GLU GLU A . n A 1 127 PHE 127 127 127 PHE PHE A . n A 1 128 ASN 128 128 128 ASN ASN A . n A 1 129 LYS 129 129 129 LYS LYS A . n A 1 130 GLU 130 130 130 GLU GLU A . n A 1 131 ILE 131 131 131 ILE ILE A . n A 1 132 PRO 132 132 132 PRO PRO A . n A 1 133 ALA 133 133 133 ALA ALA A . n A 1 134 TRP 134 134 134 TRP TRP A . n A 1 135 VAL 135 135 135 VAL VAL A . n A 1 136 PRO 136 136 136 PRO PRO A . n A 1 137 PHE 137 137 137 PHE PHE A . n A 1 138 ASP 138 138 138 ASP ASP A . n A 1 139 PRO 139 139 139 PRO PRO A . n A 1 140 ALA 140 140 140 ALA ALA A . n A 1 141 ALA 141 141 141 ALA ALA A . n A 1 142 GLN 142 142 142 GLN GLN A . n A 1 143 ILE 143 143 143 ILE ILE A . n A 1 144 THR 144 144 144 THR THR A . n A 1 145 LYS 145 145 145 LYS LYS A . n A 1 146 GLN 146 146 146 GLN GLN A . n A 1 147 LYS 147 147 147 LYS LYS A . n A 1 148 TRP 148 148 148 TRP TRP A . n A 1 149 GLU 149 149 149 GLU GLU A . n A 1 150 ALA 150 150 150 ALA ALA A . n A 1 151 GLU 151 151 151 GLU GLU A . n A 1 152 PRO 152 152 152 PRO PRO A . n A 1 153 VAL 153 153 153 VAL VAL A . n A 1 154 TYR 154 154 154 TYR TYR A . n A 1 155 VAL 155 155 155 VAL VAL A . n A 1 156 GLN 156 156 156 GLN GLN A . n A 1 157 ARG 157 157 157 ARG ARG A . n A 1 158 ALA 158 158 158 ALA ALA A . n A 1 159 LYS 159 159 159 LYS LYS A . n A 1 160 ALA 160 160 160 ALA ALA A . n A 1 161 TYR 161 161 161 TYR TYR A . n A 1 162 LEU 162 162 162 LEU LEU A . n A 1 163 GLU 163 163 163 GLU GLU A . n A 1 164 GLU 164 164 164 GLU GLU A . n A 1 165 GLU 165 165 165 GLU GLU A . n A 1 166 CYS 166 166 166 CYS CYS A . n A 1 167 PRO 167 167 167 PRO PRO A . n A 1 168 ALA 168 168 168 ALA ALA A . n A 1 169 THR 169 169 169 THR THR A . n A 1 170 LEU 170 170 170 LEU LEU A . n A 1 171 ARG 171 171 171 ARG ARG A . n A 1 172 LYS 172 172 172 LYS LYS A . n A 1 173 TYR 173 173 173 TYR TYR A . n A 1 174 LEU 174 174 174 LEU LEU A . n A 1 175 LYS 175 175 175 LYS LYS A . n A 1 176 TYR 176 176 176 TYR TYR A . n A 1 177 SER 177 177 177 SER SER A . n A 1 178 LYS 178 178 178 LYS LYS A . n A 1 179 ASN 179 179 179 ASN ASN A . n A 1 180 ILE 180 180 180 ILE ILE A . n A 1 181 LEU 181 181 181 LEU LEU A . n A 1 182 ASP 182 182 182 ASP ASP A . n A 1 183 ARG 183 183 183 ARG ARG A . n A 1 184 GLN 184 184 184 GLN GLN A . n A 1 185 ASP 185 185 185 ASP ASP A . n A 1 186 PRO 186 186 186 PRO PRO A . n A 1 187 PRO 187 187 187 PRO PRO A . n A 1 188 SER 188 188 188 SER SER A . n A 1 189 VAL 189 189 189 VAL VAL A . n A 1 190 VAL 190 190 190 VAL VAL A . n A 1 191 VAL 191 191 191 VAL VAL A . n A 1 192 THR 192 192 192 THR THR A . n A 1 193 SER 193 193 193 SER SER A . n A 1 194 HIS 194 194 194 HIS HIS A . n A 1 195 GLN 195 195 195 GLN GLN A . n A 1 196 ALA 196 196 196 ALA ALA A . n A 1 197 PRO 197 197 197 PRO PRO A . n A 1 198 GLY 198 198 198 GLY GLY A . n A 1 199 GLU 199 199 199 GLU GLU A . n A 1 200 LYS 200 200 200 LYS LYS A . n A 1 201 LYS 201 201 201 LYS LYS A . n A 1 202 LYS 202 202 202 LYS LYS A . n A 1 203 LEU 203 203 203 LEU LEU A . n A 1 204 LYS 204 204 204 LYS LYS A . n A 1 205 CYS 205 205 205 CYS CYS A . n A 1 206 LEU 206 206 206 LEU LEU A . n A 1 207 ALA 207 207 207 ALA ALA A . n A 1 208 TYR 208 208 208 TYR TYR A . n A 1 209 ASP 209 209 209 ASP ASP A . n A 1 210 PHE 210 210 210 PHE PHE A . n A 1 211 TYR 211 211 211 TYR TYR A . n A 1 212 PRO 212 212 212 PRO PRO A . n A 1 213 GLY 213 213 213 GLY GLY A . n A 1 214 LYS 214 214 214 LYS LYS A . n A 1 215 ILE 215 215 215 ILE ILE A . n A 1 216 ASP 216 216 216 ASP ASP A . n A 1 217 VAL 217 217 217 VAL VAL A . n A 1 218 HIS 218 218 218 HIS HIS A . n A 1 219 TRP 219 219 219 TRP TRP A . n A 1 220 THR 220 220 220 THR THR A . n A 1 221 ARG 221 221 221 ARG ARG A . n A 1 222 ALA 222 222 222 ALA ALA A . n A 1 223 GLY 223 223 223 GLY GLY A . n A 1 224 GLU 224 224 224 GLU GLU A . n A 1 225 VAL 225 225 225 VAL VAL A . n A 1 226 GLN 226 226 226 GLN GLN A . n A 1 227 GLU 227 227 227 GLU GLU A . n A 1 228 PRO 228 228 228 PRO PRO A . n A 1 229 GLU 229 229 229 GLU GLU A . n A 1 230 LEU 230 230 230 LEU LEU A . n A 1 231 ARG 231 231 231 ARG ARG A . n A 1 232 GLY 232 232 232 GLY GLY A . n A 1 233 ASP 233 233 233 ASP ASP A . n A 1 234 VAL 234 234 234 VAL VAL A . n A 1 235 LEU 235 235 235 LEU LEU A . n A 1 236 HIS 236 236 236 HIS HIS A . n A 1 237 ASN 237 237 237 ASN ASN A . n A 1 238 GLY 238 238 238 GLY GLY A . n A 1 239 ASN 239 239 239 ASN ASN A . n A 1 240 GLY 240 240 240 GLY GLY A . n A 1 241 THR 241 241 241 THR THR A . n A 1 242 TYR 242 242 242 TYR TYR A . n A 1 243 GLN 243 243 243 GLN GLN A . n A 1 244 SER 244 244 244 SER SER A . n A 1 245 TRP 245 245 245 TRP TRP A . n A 1 246 VAL 246 246 246 VAL VAL A . n A 1 247 VAL 247 247 247 VAL VAL A . n A 1 248 VAL 248 248 248 VAL VAL A . n A 1 249 ALA 249 249 249 ALA ALA A . n A 1 250 VAL 250 250 250 VAL VAL A . n A 1 251 PRO 251 251 251 PRO PRO A . n A 1 252 PRO 252 252 252 PRO PRO A . n A 1 253 GLN 253 253 253 GLN GLN A . n A 1 254 ASP 254 254 254 ASP ASP A . n A 1 255 THR 255 255 255 THR THR A . n A 1 256 ALA 256 256 256 ALA ALA A . n A 1 257 PRO 257 257 257 PRO PRO A . n A 1 258 TYR 258 258 258 TYR TYR A . n A 1 259 SER 259 259 259 SER SER A . n A 1 260 CYS 260 260 260 CYS CYS A . n A 1 261 HIS 261 261 261 HIS HIS A . n A 1 262 VAL 262 262 262 VAL VAL A . n A 1 263 GLN 263 263 263 GLN GLN A . n A 1 264 HIS 264 264 264 HIS HIS A . n A 1 265 SER 265 265 265 SER SER A . n A 1 266 SER 266 266 266 SER SER A . n A 1 267 LEU 267 267 267 LEU LEU A . n A 1 268 ALA 268 268 268 ALA ALA A . n A 1 269 GLN 269 269 269 GLN GLN A . n A 1 270 PRO 270 270 270 PRO PRO A . n A 1 271 LEU 271 271 271 LEU LEU A . n A 1 272 VAL 272 272 272 VAL VAL A . n A 1 273 VAL 273 273 273 VAL VAL A . n A 1 274 PRO 274 274 274 PRO PRO A . n A 1 275 TRP 275 275 275 TRP TRP A . n A 1 276 GLU 276 276 276 GLU GLU A . n A 1 277 ALA 277 277 277 ALA ALA A . n A 1 278 SER 278 278 ? ? ? A . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code B 2 NAG 1 310 310 NAG NAG A . C 2 NAG 1 320 320 NAG NAG A . D 2 NAG 2 321 321 NAG NAG A . E 3 HOH 1 322 1 HOH TIP A . E 3 HOH 2 323 2 HOH TIP A . E 3 HOH 3 324 3 HOH TIP A . E 3 HOH 4 325 4 HOH TIP A . E 3 HOH 5 326 5 HOH TIP A . E 3 HOH 6 327 6 HOH TIP A . E 3 HOH 7 328 7 HOH TIP A . E 3 HOH 8 329 8 HOH TIP A . E 3 HOH 9 330 9 HOH TIP A . E 3 HOH 10 331 10 HOH TIP A . E 3 HOH 11 332 11 HOH TIP A . E 3 HOH 12 333 12 HOH TIP A . E 3 HOH 13 334 13 HOH TIP A . E 3 HOH 14 335 14 HOH TIP A . E 3 HOH 15 336 15 HOH TIP A . E 3 HOH 16 337 16 HOH TIP A . E 3 HOH 17 338 17 HOH TIP A . E 3 HOH 18 339 18 HOH TIP A . E 3 HOH 19 340 19 HOH TIP A . E 3 HOH 20 341 20 HOH TIP A . E 3 HOH 21 342 21 HOH TIP A . E 3 HOH 22 343 22 HOH TIP A . E 3 HOH 23 344 23 HOH TIP A . E 3 HOH 24 345 24 HOH TIP A . E 3 HOH 25 346 25 HOH TIP A . E 3 HOH 26 347 26 HOH TIP A . E 3 HOH 27 348 27 HOH TIP A . E 3 HOH 28 349 28 HOH TIP A . E 3 HOH 29 350 29 HOH TIP A . E 3 HOH 30 351 30 HOH TIP A . E 3 HOH 31 352 31 HOH TIP A . E 3 HOH 32 353 32 HOH TIP A . E 3 HOH 33 354 33 HOH TIP A . E 3 HOH 34 355 34 HOH TIP A . E 3 HOH 35 356 35 HOH TIP A . E 3 HOH 36 357 36 HOH TIP A . E 3 HOH 37 358 37 HOH TIP A . E 3 HOH 38 359 38 HOH TIP A . E 3 HOH 39 360 39 HOH TIP A . E 3 HOH 40 361 40 HOH TIP A . E 3 HOH 41 362 41 HOH TIP A . E 3 HOH 42 363 42 HOH TIP A . E 3 HOH 43 364 43 HOH TIP A . E 3 HOH 44 365 44 HOH TIP A . E 3 HOH 45 366 45 HOH TIP A . E 3 HOH 46 367 46 HOH TIP A . E 3 HOH 47 368 47 HOH TIP A . E 3 HOH 48 369 48 HOH TIP A . E 3 HOH 49 370 49 HOH TIP A . E 3 HOH 50 371 50 HOH TIP A . E 3 HOH 51 372 51 HOH TIP A . E 3 HOH 52 373 52 HOH TIP A . E 3 HOH 53 374 53 HOH TIP A . E 3 HOH 54 375 54 HOH TIP A . E 3 HOH 55 376 55 HOH TIP A . E 3 HOH 56 377 56 HOH TIP A . E 3 HOH 57 378 57 HOH TIP A . E 3 HOH 58 379 58 HOH TIP A . E 3 HOH 59 380 59 HOH TIP A . E 3 HOH 60 381 60 HOH TIP A . E 3 HOH 61 382 61 HOH TIP A . E 3 HOH 62 383 62 HOH TIP A . E 3 HOH 63 384 63 HOH TIP A . E 3 HOH 64 385 64 HOH TIP A . E 3 HOH 65 386 65 HOH TIP A . E 3 HOH 66 387 66 HOH TIP A . E 3 HOH 67 388 67 HOH TIP A . E 3 HOH 68 389 68 HOH TIP A . E 3 HOH 69 390 69 HOH TIP A . E 3 HOH 70 391 70 HOH TIP A . E 3 HOH 71 392 71 HOH TIP A . E 3 HOH 72 393 72 HOH TIP A . E 3 HOH 73 394 73 HOH TIP A . E 3 HOH 74 395 74 HOH TIP A . E 3 HOH 75 396 75 HOH TIP A . E 3 HOH 76 397 76 HOH TIP A . E 3 HOH 77 398 77 HOH TIP A . E 3 HOH 78 399 78 HOH TIP A . E 3 HOH 79 400 79 HOH TIP A . E 3 HOH 80 401 80 HOH TIP A . E 3 HOH 81 402 81 HOH TIP A . E 3 HOH 82 403 82 HOH TIP A . E 3 HOH 83 404 83 HOH TIP A . E 3 HOH 84 405 84 HOH TIP A . E 3 HOH 85 406 85 HOH TIP A . E 3 HOH 86 407 86 HOH TIP A . E 3 HOH 87 408 87 HOH TIP A . E 3 HOH 88 409 88 HOH TIP A . E 3 HOH 89 410 89 HOH TIP A . E 3 HOH 90 411 90 HOH TIP A . E 3 HOH 91 412 91 HOH TIP A . E 3 HOH 92 413 92 HOH TIP A . E 3 HOH 93 414 93 HOH TIP A . E 3 HOH 94 415 94 HOH TIP A . E 3 HOH 95 416 95 HOH TIP A . E 3 HOH 96 417 96 HOH TIP A . E 3 HOH 97 418 97 HOH TIP A . E 3 HOH 98 419 98 HOH TIP A . E 3 HOH 99 420 99 HOH TIP A . E 3 HOH 100 421 100 HOH TIP A . E 3 HOH 101 422 101 HOH TIP A . E 3 HOH 102 423 102 HOH TIP A . E 3 HOH 103 424 103 HOH TIP A . E 3 HOH 104 425 104 HOH TIP A . E 3 HOH 105 426 105 HOH TIP A . E 3 HOH 106 427 106 HOH TIP A . E 3 HOH 107 428 107 HOH TIP A . E 3 HOH 108 429 108 HOH TIP A . E 3 HOH 109 430 109 HOH TIP A . E 3 HOH 110 431 110 HOH TIP A . E 3 HOH 111 432 111 HOH TIP A . E 3 HOH 112 433 112 HOH TIP A . E 3 HOH 113 434 113 HOH TIP A . E 3 HOH 114 435 114 HOH TIP A . E 3 HOH 115 436 115 HOH TIP A . E 3 HOH 116 437 116 HOH TIP A . E 3 HOH 117 438 117 HOH TIP A . E 3 HOH 118 439 118 HOH TIP A . E 3 HOH 119 440 119 HOH TIP A . E 3 HOH 120 441 120 HOH TIP A . E 3 HOH 121 442 121 HOH TIP A . E 3 HOH 122 443 122 HOH TIP A . E 3 HOH 123 444 123 HOH TIP A . E 3 HOH 124 445 124 HOH TIP A . E 3 HOH 125 446 125 HOH TIP A . E 3 HOH 126 447 126 HOH TIP A . E 3 HOH 127 448 127 HOH TIP A . E 3 HOH 128 449 128 HOH TIP A . E 3 HOH 129 450 129 HOH TIP A . E 3 HOH 130 451 130 HOH TIP A . E 3 HOH 131 452 131 HOH TIP A . E 3 HOH 132 453 132 HOH TIP A . E 3 HOH 133 454 133 HOH TIP A . E 3 HOH 134 455 134 HOH TIP A . E 3 HOH 135 456 135 HOH TIP A . E 3 HOH 136 457 136 HOH TIP A . E 3 HOH 137 458 137 HOH TIP A . E 3 HOH 138 459 138 HOH TIP A . E 3 HOH 139 460 139 HOH TIP A . E 3 HOH 140 461 140 HOH TIP A . E 3 HOH 141 462 141 HOH TIP A . E 3 HOH 142 463 142 HOH TIP A . E 3 HOH 143 464 143 HOH TIP A . E 3 HOH 144 465 144 HOH TIP A . E 3 HOH 145 466 145 HOH TIP A . E 3 HOH 146 467 146 HOH TIP A . E 3 HOH 147 468 147 HOH TIP A . E 3 HOH 148 469 148 HOH TIP A . E 3 HOH 149 470 149 HOH TIP A . E 3 HOH 150 471 150 HOH TIP A . E 3 HOH 151 472 151 HOH TIP A . E 3 HOH 152 473 152 HOH TIP A . E 3 HOH 153 474 153 HOH TIP A . E 3 HOH 154 475 154 HOH TIP A . E 3 HOH 155 476 155 HOH TIP A . E 3 HOH 156 477 156 HOH TIP A . E 3 HOH 157 478 157 HOH TIP A . E 3 HOH 158 479 158 HOH TIP A . E 3 HOH 159 480 159 HOH TIP A . E 3 HOH 160 481 160 HOH TIP A . E 3 HOH 161 482 161 HOH TIP A . E 3 HOH 162 483 162 HOH TIP A . E 3 HOH 163 484 163 HOH TIP A . E 3 HOH 164 485 164 HOH TIP A . E 3 HOH 165 486 165 HOH TIP A . E 3 HOH 166 487 166 HOH TIP A . E 3 HOH 167 488 167 HOH TIP A . E 3 HOH 168 489 168 HOH TIP A . E 3 HOH 169 490 169 HOH TIP A . E 3 HOH 170 491 170 HOH TIP A . E 3 HOH 171 492 171 HOH TIP A . E 3 HOH 172 493 172 HOH TIP A . E 3 HOH 173 494 173 HOH TIP A . E 3 HOH 174 495 174 HOH TIP A . E 3 HOH 175 496 175 HOH TIP A . E 3 HOH 176 497 176 HOH TIP A . E 3 HOH 177 498 177 HOH TIP A . E 3 HOH 178 499 178 HOH TIP A . E 3 HOH 179 500 179 HOH TIP A . E 3 HOH 180 501 180 HOH TIP A . E 3 HOH 181 502 181 HOH TIP A . E 3 HOH 182 503 182 HOH TIP A . E 3 HOH 183 504 183 HOH TIP A . E 3 HOH 184 505 184 HOH TIP A . E 3 HOH 185 506 185 HOH TIP A . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 108 A ASN 108 ? ASN 'GLYCOSYLATION SITE' 2 A ASN 239 A ASN 239 ? ASN 'GLYCOSYLATION SITE' # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_defined_assembly _pdbx_struct_assembly.method_details ? _pdbx_struct_assembly.oligomeric_details monomeric _pdbx_struct_assembly.oligomeric_count 1 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # _pdbx_struct_special_symmetry.id 1 _pdbx_struct_special_symmetry.PDB_model_num 1 _pdbx_struct_special_symmetry.auth_asym_id A _pdbx_struct_special_symmetry.auth_comp_id HOH _pdbx_struct_special_symmetry.auth_seq_id 458 _pdbx_struct_special_symmetry.PDB_ins_code ? _pdbx_struct_special_symmetry.label_asym_id E _pdbx_struct_special_symmetry.label_comp_id HOH _pdbx_struct_special_symmetry.label_seq_id . # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2004-12-21 2 'Structure model' 1 1 2008-04-30 3 'Structure model' 1 2 2011-07-13 4 'Structure model' 1 3 2017-10-11 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Version format compliance' 2 3 'Structure model' 'Non-polymer description' 3 3 'Structure model' 'Version format compliance' 4 4 'Structure model' 'Refinement description' # _pdbx_audit_revision_category.ordinal 1 _pdbx_audit_revision_category.revision_ordinal 4 _pdbx_audit_revision_category.data_content_type 'Structure model' _pdbx_audit_revision_category.category software # loop_ _refine_B_iso.class _refine_B_iso.treatment _refine_B_iso.pdbx_refine_id _refine_B_iso.details polymer isotropic 'X-RAY DIFFRACTION' ? water isotropic 'X-RAY DIFFRACTION' ? # _phasing.method MR # loop_ _software.name _software.version _software.date _software.type _software.contact_author _software.contact_author_email _software.classification _software.location _software.language _software.citation_id _software.pdbx_ordinal CNS 1.1 1998 package 'Axel T. Brunger' axel.brunger@yale.edu refinement http://cns.csb.yale.edu/v1.1/ Fortran_77 ? 1 DENZO . ? package 'Zbyszek Otwinowski' zbyszek@mix.swmed.edu 'data reduction' http://www.lnls.br/infra/linhasluz/denzo-hkl.htm ? ? 2 SCALEPACK . ? package 'Zbyszek Otwinowski' zbyszek@mix.swmed.edu 'data scaling' http://www.lnls.br/infra/linhasluz/denzo-hkl.htm ? ? 3 AMoRE . ? ? ? ? phasing ? ? ? 4 # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 ASN A 34 ? ? 57.01 -126.74 2 1 ASP A 90 ? ? -142.85 52.78 3 1 TRP A 115 ? ? -163.58 105.54 4 1 PRO A 197 ? ? -55.28 100.94 5 1 ALA A 256 ? ? -46.68 156.33 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A GLN 1 ? A GLN 1 2 1 Y 1 A GLU 2 ? A GLU 2 3 1 Y 1 A ASN 3 ? A ASN 3 4 1 Y 1 A GLN 4 ? A GLN 4 5 1 Y 1 A SER 278 ? A SER 278 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 water HOH #