data_5FBG # _entry.id 5FBG # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 5FBG WWPDB D_1000215846 # loop_ _pdbx_database_related.db_name _pdbx_database_related.details _pdbx_database_related.db_id _pdbx_database_related.content_type PDB '5FB9 contains the wild type of the same protein with unoccupied active site' 5FB9 unspecified PDB '5FBA contains the wild type of the same protein in complex with phosphate' 5FBA unspecified PDB ;5FBB contains the wild type of the same protein in complex with phosphate and adenosine 5'-monophosphate ; 5FBB unspecified PDB ;5FBC contains the wild type of the same protein in complex with 2'-deoxyadenosine-5'-thio-monophosphate (5'dAMP(S)) ; 5FBC unspecified PDB ;5FBD contains the wild type of the same protein in complex with phosphate and 2'-deoxycytidine ; 5FBD unspecified PDB ;5FBF contains the wild type of the same protein in complex with two molecules of 2'-deoxycytidine-5'-monophosphate ; 5FBF unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.entry_id 5FBG _pdbx_database_status.recvd_initial_deposition_date 2015-12-14 _pdbx_database_status.SG_entry N _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site PDBE _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? _pdbx_database_status.pdb_format_compatible Y # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Koval, T.' 1 'Oestergaard, L.H.' 2 'Dohnalek, J.' 3 # _citation.abstract ? _citation.abstract_id_CAS ? _citation.book_id_ISBN ? _citation.book_publisher ? _citation.book_publisher_city ? _citation.book_title ? _citation.coordinate_linkage ? _citation.country US _citation.database_id_Medline ? _citation.details ? _citation.id primary _citation.journal_abbrev 'PLoS ONE' _citation.journal_id_ASTM ? _citation.journal_id_CSD ? _citation.journal_id_ISSN 1932-6203 _citation.journal_full ? _citation.journal_issue ? _citation.journal_volume 11 _citation.language ? _citation.page_first e0168832 _citation.page_last e0168832 _citation.title ;Structural and Catalytic Properties of S1 Nuclease from Aspergillus oryzae Responsible for Substrate Recognition, Cleavage, Non-Specificity, and Inhibition. ; _citation.year 2016 _citation.database_id_CSD ? _citation.pdbx_database_id_DOI 10.1371/journal.pone.0168832 _citation.pdbx_database_id_PubMed 28036383 _citation.unpublished_flag ? # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Koval, T.' 1 primary 'stergaard, L.H.' 2 primary 'Lehmbeck, J.' 3 primary 'Nrgaard, A.' 4 primary 'Lipovova, P.' 5 primary 'Duskova, J.' 6 primary 'Skalova, T.' 7 primary 'Trundova, M.' 8 primary 'Kolenko, P.' 9 primary 'Fejfarova, K.' 10 primary 'Stransky, J.' 11 primary 'Svecova, L.' 12 primary 'Hasek, J.' 13 primary 'Dohnalek, J.' 14 # _cell.angle_alpha 90.00 _cell.angle_alpha_esd ? _cell.angle_beta 90.00 _cell.angle_beta_esd ? _cell.angle_gamma 120.00 _cell.angle_gamma_esd ? _cell.entry_id 5FBG _cell.details ? _cell.formula_units_Z ? _cell.length_a 106.760 _cell.length_a_esd ? _cell.length_b 106.760 _cell.length_b_esd ? _cell.length_c 127.910 _cell.length_c_esd ? _cell.volume ? _cell.volume_esd ? _cell.Z_PDB 12 _cell.reciprocal_angle_alpha ? _cell.reciprocal_angle_beta ? _cell.reciprocal_angle_gamma ? _cell.reciprocal_angle_alpha_esd ? _cell.reciprocal_angle_beta_esd ? _cell.reciprocal_angle_gamma_esd ? _cell.reciprocal_length_a ? _cell.reciprocal_length_b ? _cell.reciprocal_length_c ? _cell.reciprocal_length_a_esd ? _cell.reciprocal_length_b_esd ? _cell.reciprocal_length_c_esd ? _cell.pdbx_unique_axis ? # _symmetry.entry_id 5FBG _symmetry.cell_setting ? _symmetry.Int_Tables_number 152 _symmetry.space_group_name_Hall ? _symmetry.space_group_name_H-M 'P 31 2 1' _symmetry.pdbx_full_space_group_name_H-M ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'Nuclease S1' 29082.676 2 3.1.30.1 D65N ? 'Mature protein without signal sequence.' 2 non-polymer syn 'ZINC ION' 65.409 6 ? ? ? ? 3 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 4 ? ? ? ? 4 non-polymer syn 'PHOSPHATE ION' 94.971 2 ? ? ? ? 5 non-polymer syn "2'-DEOXYCYTIDINE" 227.217 2 ? ? ? ? 6 non-polymer syn "2'-DEOXY-GUANOSINE" 267.241 1 ? ? ? ? 7 water nat water 18.015 652 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name 'Deoxyribonuclease S1,Endonuclease S1,Single-stranded-nucleate endonuclease' # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;WGNLGHETVAYIAQSFVASSTESFCQNILGDDSTSYLANVATWANTYKYTDAGEFSKPYHFIDAQDNPPQSCGVDYDRDC GSAGCSISAIQNYTNILLESPNGSEALNALKFVVHIIGDIHQPLHDENLEAGGNGIDVTYDGETTNLHHIWDTNMPEEAA GGYSLSVAKTYADLLTERIKTGTYSSKKDSWTDGIDIKDPVSTSMIWAADANTYVCSTVLDDGLAYINSTDLSGEYYDKS QPVFEELIAKAGYRLAAWLDLIASQPS ; _entity_poly.pdbx_seq_one_letter_code_can ;WGNLGHETVAYIAQSFVASSTESFCQNILGDDSTSYLANVATWANTYKYTDAGEFSKPYHFIDAQDNPPQSCGVDYDRDC GSAGCSISAIQNYTNILLESPNGSEALNALKFVVHIIGDIHQPLHDENLEAGGNGIDVTYDGETTNLHHIWDTNMPEEAA GGYSLSVAKTYADLLTERIKTGTYSSKKDSWTDGIDIKDPVSTSMIWAADANTYVCSTVLDDGLAYINSTDLSGEYYDKS QPVFEELIAKAGYRLAAWLDLIASQPS ; _entity_poly.pdbx_strand_id A,B _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 TRP n 1 2 GLY n 1 3 ASN n 1 4 LEU n 1 5 GLY n 1 6 HIS n 1 7 GLU n 1 8 THR n 1 9 VAL n 1 10 ALA n 1 11 TYR n 1 12 ILE n 1 13 ALA n 1 14 GLN n 1 15 SER n 1 16 PHE n 1 17 VAL n 1 18 ALA n 1 19 SER n 1 20 SER n 1 21 THR n 1 22 GLU n 1 23 SER n 1 24 PHE n 1 25 CYS n 1 26 GLN n 1 27 ASN n 1 28 ILE n 1 29 LEU n 1 30 GLY n 1 31 ASP n 1 32 ASP n 1 33 SER n 1 34 THR n 1 35 SER n 1 36 TYR n 1 37 LEU n 1 38 ALA n 1 39 ASN n 1 40 VAL n 1 41 ALA n 1 42 THR n 1 43 TRP n 1 44 ALA n 1 45 ASN n 1 46 THR n 1 47 TYR n 1 48 LYS n 1 49 TYR n 1 50 THR n 1 51 ASP n 1 52 ALA n 1 53 GLY n 1 54 GLU n 1 55 PHE n 1 56 SER n 1 57 LYS n 1 58 PRO n 1 59 TYR n 1 60 HIS n 1 61 PHE n 1 62 ILE n 1 63 ASP n 1 64 ALA n 1 65 GLN n 1 66 ASP n 1 67 ASN n 1 68 PRO n 1 69 PRO n 1 70 GLN n 1 71 SER n 1 72 CYS n 1 73 GLY n 1 74 VAL n 1 75 ASP n 1 76 TYR n 1 77 ASP n 1 78 ARG n 1 79 ASP n 1 80 CYS n 1 81 GLY n 1 82 SER n 1 83 ALA n 1 84 GLY n 1 85 CYS n 1 86 SER n 1 87 ILE n 1 88 SER n 1 89 ALA n 1 90 ILE n 1 91 GLN n 1 92 ASN n 1 93 TYR n 1 94 THR n 1 95 ASN n 1 96 ILE n 1 97 LEU n 1 98 LEU n 1 99 GLU n 1 100 SER n 1 101 PRO n 1 102 ASN n 1 103 GLY n 1 104 SER n 1 105 GLU n 1 106 ALA n 1 107 LEU n 1 108 ASN n 1 109 ALA n 1 110 LEU n 1 111 LYS n 1 112 PHE n 1 113 VAL n 1 114 VAL n 1 115 HIS n 1 116 ILE n 1 117 ILE n 1 118 GLY n 1 119 ASP n 1 120 ILE n 1 121 HIS n 1 122 GLN n 1 123 PRO n 1 124 LEU n 1 125 HIS n 1 126 ASP n 1 127 GLU n 1 128 ASN n 1 129 LEU n 1 130 GLU n 1 131 ALA n 1 132 GLY n 1 133 GLY n 1 134 ASN n 1 135 GLY n 1 136 ILE n 1 137 ASP n 1 138 VAL n 1 139 THR n 1 140 TYR n 1 141 ASP n 1 142 GLY n 1 143 GLU n 1 144 THR n 1 145 THR n 1 146 ASN n 1 147 LEU n 1 148 HIS n 1 149 HIS n 1 150 ILE n 1 151 TRP n 1 152 ASP n 1 153 THR n 1 154 ASN n 1 155 MET n 1 156 PRO n 1 157 GLU n 1 158 GLU n 1 159 ALA n 1 160 ALA n 1 161 GLY n 1 162 GLY n 1 163 TYR n 1 164 SER n 1 165 LEU n 1 166 SER n 1 167 VAL n 1 168 ALA n 1 169 LYS n 1 170 THR n 1 171 TYR n 1 172 ALA n 1 173 ASP n 1 174 LEU n 1 175 LEU n 1 176 THR n 1 177 GLU n 1 178 ARG n 1 179 ILE n 1 180 LYS n 1 181 THR n 1 182 GLY n 1 183 THR n 1 184 TYR n 1 185 SER n 1 186 SER n 1 187 LYS n 1 188 LYS n 1 189 ASP n 1 190 SER n 1 191 TRP n 1 192 THR n 1 193 ASP n 1 194 GLY n 1 195 ILE n 1 196 ASP n 1 197 ILE n 1 198 LYS n 1 199 ASP n 1 200 PRO n 1 201 VAL n 1 202 SER n 1 203 THR n 1 204 SER n 1 205 MET n 1 206 ILE n 1 207 TRP n 1 208 ALA n 1 209 ALA n 1 210 ASP n 1 211 ALA n 1 212 ASN n 1 213 THR n 1 214 TYR n 1 215 VAL n 1 216 CYS n 1 217 SER n 1 218 THR n 1 219 VAL n 1 220 LEU n 1 221 ASP n 1 222 ASP n 1 223 GLY n 1 224 LEU n 1 225 ALA n 1 226 TYR n 1 227 ILE n 1 228 ASN n 1 229 SER n 1 230 THR n 1 231 ASP n 1 232 LEU n 1 233 SER n 1 234 GLY n 1 235 GLU n 1 236 TYR n 1 237 TYR n 1 238 ASP n 1 239 LYS n 1 240 SER n 1 241 GLN n 1 242 PRO n 1 243 VAL n 1 244 PHE n 1 245 GLU n 1 246 GLU n 1 247 LEU n 1 248 ILE n 1 249 ALA n 1 250 LYS n 1 251 ALA n 1 252 GLY n 1 253 TYR n 1 254 ARG n 1 255 LEU n 1 256 ALA n 1 257 ALA n 1 258 TRP n 1 259 LEU n 1 260 ASP n 1 261 LEU n 1 262 ILE n 1 263 ALA n 1 264 SER n 1 265 GLN n 1 266 PRO n 1 267 SER n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type 'Biological sequence' _entity_src_gen.pdbx_beg_seq_num 1 _entity_src_gen.pdbx_end_seq_num 267 _entity_src_gen.gene_src_common_name 'Yellow koji mold' _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene 'nucS, AO090001000075' _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Aspergillus oryzae RIB40' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 510516 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'Aspergillus oryzae' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 5062 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain ? _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type ? _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name ? _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code NUS1_ASPOR _struct_ref.pdbx_db_accession P24021 _struct_ref.pdbx_db_isoform ? _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;WGNLGHETVAYIAQSFVASSTESFCQNILGDDSTSYLANVATWADTYKYTDAGEFSKPYHFIDAQDNPPQSCGVDYDRDC GSAGCSISAIQNYTNILLESPNGSEALNALKFVVHIIGDIHQPLHDENLEAGGNGIDVTYDGETTNLHHIWDTNMPEEAA GGYSLSVAKTYADLLTERIKTGTYSSKKDSWTDGIDIKDPVSTSMIWAADANTYVCSTVLDDGLAYINSTDLSGEYYDKS QPVFEELIAKAGYRLAAWLDLIASQPS ; _struct_ref.pdbx_align_begin 21 # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 5FBG A 1 ? 267 ? P24021 21 ? 287 ? 21 287 2 1 5FBG B 1 ? 267 ? P24021 21 ? 287 ? 21 287 # loop_ _struct_ref_seq_dif.align_id _struct_ref_seq_dif.pdbx_pdb_id_code _struct_ref_seq_dif.mon_id _struct_ref_seq_dif.pdbx_pdb_strand_id _struct_ref_seq_dif.seq_num _struct_ref_seq_dif.pdbx_pdb_ins_code _struct_ref_seq_dif.pdbx_seq_db_name _struct_ref_seq_dif.pdbx_seq_db_accession_code _struct_ref_seq_dif.db_mon_id _struct_ref_seq_dif.pdbx_seq_db_seq_num _struct_ref_seq_dif.details _struct_ref_seq_dif.pdbx_auth_seq_num _struct_ref_seq_dif.pdbx_ordinal 1 5FBG ASN A 45 ? UNP P24021 ASP 65 'engineered mutation' 65 1 2 5FBG ASN B 45 ? UNP P24021 ASP 65 'engineered mutation' 65 2 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 DCZ non-polymer . "2'-DEOXYCYTIDINE" ? 'C9 H13 N3 O4' 227.217 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 GNG non-polymer n "2'-DEOXY-GUANOSINE" ? 'C10 H13 N5 O4' 267.241 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PO4 non-polymer . 'PHOSPHATE ION' ? 'O4 P -3' 94.971 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 ZN non-polymer . 'ZINC ION' ? 'Zn 2' 65.409 # _exptl.absorpt_coefficient_mu ? _exptl.absorpt_correction_T_max ? _exptl.absorpt_correction_T_min ? _exptl.absorpt_correction_type ? _exptl.absorpt_process_details ? _exptl.entry_id 5FBG _exptl.crystals_number ? _exptl.details ? _exptl.method 'X-RAY DIFFRACTION' _exptl.method_details ? # _exptl_crystal.colour ? _exptl_crystal.density_diffrn ? _exptl_crystal.density_Matthews 3.64 _exptl_crystal.density_method ? _exptl_crystal.density_percent_sol 66.2 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.id 1 _exptl_crystal.preparation ? _exptl_crystal.size_max ? _exptl_crystal.size_mid ? _exptl_crystal.size_min ? _exptl_crystal.size_rad ? _exptl_crystal.colour_lustre ? _exptl_crystal.colour_modifier ? _exptl_crystal.colour_primary ? _exptl_crystal.density_meas ? _exptl_crystal.density_meas_esd ? _exptl_crystal.density_meas_gt ? _exptl_crystal.density_meas_lt ? _exptl_crystal.density_meas_temp ? _exptl_crystal.density_meas_temp_esd ? _exptl_crystal.density_meas_temp_gt ? _exptl_crystal.density_meas_temp_lt ? _exptl_crystal.pdbx_crystal_image_url ? _exptl_crystal.pdbx_crystal_image_format ? _exptl_crystal.pdbx_mosaicity ? _exptl_crystal.pdbx_mosaicity_esd ? # _exptl_crystal_grow.apparatus ? _exptl_crystal_grow.atmosphere ? _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.details ? _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.method_ref ? _exptl_crystal_grow.pH 5.5 _exptl_crystal_grow.pressure ? _exptl_crystal_grow.pressure_esd ? _exptl_crystal_grow.seeding ? _exptl_crystal_grow.seeding_ref ? _exptl_crystal_grow.temp 291 _exptl_crystal_grow.temp_details stable _exptl_crystal_grow.temp_esd ? _exptl_crystal_grow.time ? _exptl_crystal_grow.pdbx_details '0.2 M Sodium chloride, 0.1 M BIS-TRIS pH 5.5, 25% w/v Polyethylene glycol 3,350' _exptl_crystal_grow.pdbx_pH_range ? # _diffrn.ambient_environment ? _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.ambient_temp_esd ? _diffrn.crystal_id 1 _diffrn.crystal_support ? _diffrn.crystal_treatment ? _diffrn.details ? _diffrn.id 1 _diffrn.ambient_pressure ? _diffrn.ambient_pressure_esd ? _diffrn.ambient_pressure_gt ? _diffrn.ambient_pressure_lt ? _diffrn.ambient_temp_gt ? _diffrn.ambient_temp_lt ? # _diffrn_detector.details ? _diffrn_detector.detector CCD _diffrn_detector.diffrn_id 1 _diffrn_detector.type 'MARMOSAIC 225 mm CCD' _diffrn_detector.area_resol_mean ? _diffrn_detector.dtime ? _diffrn_detector.pdbx_frames_total ? _diffrn_detector.pdbx_collection_time_total ? _diffrn_detector.pdbx_collection_date 2013-12-04 # _diffrn_radiation.collimation ? _diffrn_radiation.diffrn_id 1 _diffrn_radiation.filter_edge ? _diffrn_radiation.inhomogeneity ? _diffrn_radiation.monochromator ? _diffrn_radiation.polarisn_norm ? _diffrn_radiation.polarisn_ratio ? _diffrn_radiation.probe ? _diffrn_radiation.type ? _diffrn_radiation.xray_symbol ? _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.pdbx_wavelength_list ? _diffrn_radiation.pdbx_wavelength ? _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_analyzer ? _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.91841 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.current ? _diffrn_source.details ? _diffrn_source.diffrn_id 1 _diffrn_source.power ? _diffrn_source.size ? _diffrn_source.source SYNCHROTRON _diffrn_source.target ? _diffrn_source.type 'BESSY BEAMLINE 14.2' _diffrn_source.voltage ? _diffrn_source.take-off_angle ? _diffrn_source.pdbx_wavelength_list 0.91841 _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_synchrotron_beamline 14.2 _diffrn_source.pdbx_synchrotron_site BESSY # _reflns.B_iso_Wilson_estimate 10.4 _reflns.entry_id 5FBG _reflns.data_reduction_details ? _reflns.data_reduction_method ? _reflns.d_resolution_high 1.97 _reflns.d_resolution_low 37.47 _reflns.details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.number_all ? _reflns.number_obs 59852 _reflns.observed_criterion ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.observed_criterion_I_max ? _reflns.observed_criterion_I_min ? _reflns.observed_criterion_sigma_F ? _reflns.observed_criterion_sigma_I ? _reflns.percent_possible_obs 99.6 _reflns.R_free_details ? _reflns.Rmerge_F_all ? _reflns.Rmerge_F_obs ? _reflns.Friedel_coverage ? _reflns.number_gt ? _reflns.threshold_expression ? _reflns.pdbx_redundancy 5.8 _reflns.pdbx_Rmerge_I_obs 0.131 _reflns.pdbx_Rmerge_I_all ? _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_av_sigmaI ? _reflns.pdbx_netI_over_sigmaI 9.3 _reflns.pdbx_res_netI_over_av_sigmaI_2 ? _reflns.pdbx_res_netI_over_sigmaI_2 ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_d_res_high_opt ? _reflns.pdbx_d_res_low_opt ? _reflns.pdbx_d_res_opt_method ? _reflns.phase_calculation_details ? _reflns.pdbx_Rrim_I_all ? _reflns.pdbx_Rpim_I_all ? _reflns.pdbx_d_opt ? _reflns.pdbx_number_measured_all ? _reflns.pdbx_diffrn_id 1 _reflns.pdbx_ordinal 1 _reflns.pdbx_CC_half ? _reflns.pdbx_R_split ? # _reflns_shell.d_res_high 1.97 _reflns_shell.d_res_low 2.02 _reflns_shell.meanI_over_sigI_all ? _reflns_shell.meanI_over_sigI_obs 2.0 _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_possible ? _reflns_shell.number_unique_all ? _reflns_shell.number_unique_obs ? _reflns_shell.percent_possible_all 97.6 _reflns_shell.percent_possible_obs ? _reflns_shell.Rmerge_F_all ? _reflns_shell.Rmerge_F_obs ? _reflns_shell.Rmerge_I_all ? _reflns_shell.Rmerge_I_obs 0.645 _reflns_shell.meanI_over_sigI_gt ? _reflns_shell.meanI_over_uI_all ? _reflns_shell.meanI_over_uI_gt ? _reflns_shell.number_measured_gt ? _reflns_shell.number_unique_gt ? _reflns_shell.percent_possible_gt ? _reflns_shell.Rmerge_F_gt ? _reflns_shell.Rmerge_I_gt ? _reflns_shell.pdbx_redundancy 3.6 _reflns_shell.pdbx_Rsym_value ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_netI_over_sigmaI_all ? _reflns_shell.pdbx_netI_over_sigmaI_obs ? _reflns_shell.pdbx_Rrim_I_all ? _reflns_shell.pdbx_Rpim_I_all ? _reflns_shell.pdbx_rejects ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 _reflns_shell.pdbx_CC_half ? _reflns_shell.pdbx_R_split ? # _refine.aniso_B[1][1] 0.35 _refine.aniso_B[1][2] 0.18 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][2] 0.35 _refine.aniso_B[2][3] -0.00 _refine.aniso_B[3][3] -1.14 _refine.B_iso_max ? _refine.B_iso_mean 21.934 _refine.B_iso_min ? _refine.correlation_coeff_Fo_to_Fc 0.963 _refine.correlation_coeff_Fo_to_Fc_free ? _refine.details 'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' _refine.diff_density_max ? _refine.diff_density_max_esd ? _refine.diff_density_min ? _refine.diff_density_min_esd ? _refine.diff_density_rms ? _refine.diff_density_rms_esd ? _refine.entry_id 5FBG _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.ls_abs_structure_details ? _refine.ls_abs_structure_Flack ? _refine.ls_abs_structure_Flack_esd ? _refine.ls_abs_structure_Rogers ? _refine.ls_abs_structure_Rogers_esd ? _refine.ls_d_res_high 1.97 _refine.ls_d_res_low 37.47 _refine.ls_extinction_coef ? _refine.ls_extinction_coef_esd ? _refine.ls_extinction_expression ? _refine.ls_extinction_method ? _refine.ls_goodness_of_fit_all ? _refine.ls_goodness_of_fit_all_esd ? _refine.ls_goodness_of_fit_obs ? _refine.ls_goodness_of_fit_obs_esd ? _refine.ls_hydrogen_treatment ? _refine.ls_matrix_type ? _refine.ls_number_constraints ? _refine.ls_number_parameters ? _refine.ls_number_reflns_all ? _refine.ls_number_reflns_obs 59809 _refine.ls_number_reflns_R_free 3024 _refine.ls_number_reflns_R_work ? _refine.ls_number_restraints ? _refine.ls_percent_reflns_obs 99.63 _refine.ls_percent_reflns_R_free 5.1 _refine.ls_R_factor_all ? _refine.ls_R_factor_obs 0.15889 _refine.ls_R_factor_R_free 0.18705 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_R_factor_R_work 0.15790 _refine.ls_R_Fsqd_factor_obs ? _refine.ls_R_I_factor_obs ? _refine.ls_redundancy_reflns_all ? _refine.ls_redundancy_reflns_obs ? _refine.ls_restrained_S_all ? _refine.ls_restrained_S_obs ? _refine.ls_shift_over_esd_max ? _refine.ls_shift_over_esd_mean ? _refine.ls_structure_factor_coef ? _refine.ls_weighting_details ? _refine.ls_weighting_scheme ? _refine.ls_wR_factor_all ? _refine.ls_wR_factor_obs ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.occupancy_max ? _refine.occupancy_min ? _refine.solvent_model_details MASK _refine.solvent_model_param_bsol ? _refine.solvent_model_param_ksol ? _refine.ls_R_factor_gt ? _refine.ls_goodness_of_fit_gt ? _refine.ls_goodness_of_fit_ref ? _refine.ls_shift_over_su_max ? _refine.ls_shift_over_su_max_lt ? _refine.ls_shift_over_su_mean ? _refine.ls_shift_over_su_mean_lt ? _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F ? _refine.pdbx_ls_sigma_Fsqd ? _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_starting_model 'our previous model of S1' _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_R_Free_selection_details 'Random selection' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_overall_ESU_R 0.110 _refine.pdbx_overall_ESU_R_Free ? _refine.pdbx_solvent_vdw_probe_radii 1.20 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_real_space_R ? _refine.pdbx_density_correlation ? _refine.pdbx_pd_number_of_powder_patterns ? _refine.pdbx_pd_number_of_points ? _refine.pdbx_pd_meas_number_of_points ? _refine.pdbx_pd_proc_ls_prof_R_factor ? _refine.pdbx_pd_proc_ls_prof_wR_factor ? _refine.pdbx_pd_Marquardt_correlation_coeff ? _refine.pdbx_pd_Fsqrd_R_factor ? _refine.pdbx_pd_ls_matrix_band_width ? _refine.pdbx_overall_phase_error ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_diffrn_id 1 _refine.overall_SU_B 2.655 _refine.overall_SU_ML 0.070 _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_average_fsc_overall ? _refine.pdbx_average_fsc_work ? _refine.pdbx_average_fsc_free ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id 1 _refine_hist.pdbx_number_atoms_protein 4084 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 123 _refine_hist.number_atoms_solvent 652 _refine_hist.number_atoms_total 4859 _refine_hist.d_res_high 1.97 _refine_hist.d_res_low 37.47 # loop_ _refine_ls_restr.pdbx_refine_id _refine_ls_restr.criterion _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.number _refine_ls_restr.rejects _refine_ls_restr.type _refine_ls_restr.weight _refine_ls_restr.pdbx_restraint_function 'X-RAY DIFFRACTION' ? 0.016 0.019 4387 ? r_bond_refined_d ? ? 'X-RAY DIFFRACTION' ? 0.009 0.020 3816 ? r_bond_other_d ? ? 'X-RAY DIFFRACTION' ? 1.598 1.942 6018 ? r_angle_refined_deg ? ? 'X-RAY DIFFRACTION' ? 1.483 3.001 8850 ? r_angle_other_deg ? ? 'X-RAY DIFFRACTION' ? 5.547 5.000 550 ? r_dihedral_angle_1_deg ? ? 'X-RAY DIFFRACTION' ? 38.276 26.039 207 ? r_dihedral_angle_2_deg ? ? 'X-RAY DIFFRACTION' ? 12.465 15.000 645 ? r_dihedral_angle_3_deg ? ? 'X-RAY DIFFRACTION' ? 11.605 15.000 6 ? r_dihedral_angle_4_deg ? ? 'X-RAY DIFFRACTION' ? 0.108 0.200 673 ? r_chiral_restr ? ? 'X-RAY DIFFRACTION' ? 0.010 0.020 5215 ? r_gen_planes_refined ? ? 'X-RAY DIFFRACTION' ? 0.006 0.020 979 ? r_gen_planes_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_nbd_refined ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_nbd_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_nbtor_refined ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_nbtor_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_xyhbond_nbd_refined ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_xyhbond_nbd_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_metal_ion_refined ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_metal_ion_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_symmetry_vdw_refined ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_symmetry_vdw_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_symmetry_hbond_refined ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_symmetry_hbond_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_symmetry_metal_ion_refined ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_symmetry_metal_ion_other ? ? 'X-RAY DIFFRACTION' ? 1.587 1.971 2149 ? r_mcbond_it ? ? 'X-RAY DIFFRACTION' ? 1.580 1.969 2148 ? r_mcbond_other ? ? 'X-RAY DIFFRACTION' ? 2.261 2.947 2689 ? r_mcangle_it ? ? 'X-RAY DIFFRACTION' ? 2.261 2.950 2690 ? r_mcangle_other ? ? 'X-RAY DIFFRACTION' ? 2.356 2.272 2238 ? r_scbond_it ? ? 'X-RAY DIFFRACTION' ? 2.355 2.274 2239 ? r_scbond_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_scangle_it ? ? 'X-RAY DIFFRACTION' ? 3.656 3.324 3321 ? r_scangle_other ? ? 'X-RAY DIFFRACTION' ? 6.252 18.028 5840 ? r_long_range_B_refined ? ? 'X-RAY DIFFRACTION' ? 5.644 17.182 5522 ? r_long_range_B_other ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_rigid_bond_restr ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_sphericity_free ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? r_sphericity_bonded ? ? # loop_ _refine_ls_restr_ncs.pdbx_refine_id _refine_ls_restr_ncs.dom_id _refine_ls_restr_ncs.pdbx_ens_id _refine_ls_restr_ncs.pdbx_ordinal _refine_ls_restr_ncs.ncs_model_details _refine_ls_restr_ncs.rms_dev_position _refine_ls_restr_ncs.weight_position _refine_ls_restr_ncs.rms_dev_B_iso _refine_ls_restr_ncs.weight_B_iso _refine_ls_restr_ncs.pdbx_auth_asym_id _refine_ls_restr_ncs.pdbx_number _refine_ls_restr_ncs.pdbx_type 'X-RAY DIFFRACTION' 1 1 1 ? 0.09 0.05 ? ? A 31476 'interatomic distance' 'X-RAY DIFFRACTION' 2 1 2 ? 0.09 0.05 ? ? B 31476 'interatomic distance' # _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_ls_shell.d_res_high 1.970 _refine_ls_shell.d_res_low 2.021 _refine_ls_shell.number_reflns_all ? _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.number_reflns_R_free 200 _refine_ls_shell.number_reflns_R_work 4071 _refine_ls_shell.percent_reflns_obs 97.65 _refine_ls_shell.percent_reflns_R_free 4.7 _refine_ls_shell.R_factor_all ? _refine_ls_shell.R_factor_obs ? _refine_ls_shell.R_factor_R_free 0.263 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.R_factor_R_work 0.264 _refine_ls_shell.redundancy_reflns_all ? _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.wR_factor_all ? _refine_ls_shell.wR_factor_obs ? _refine_ls_shell.wR_factor_R_free ? _refine_ls_shell.wR_factor_R_work ? _refine_ls_shell.pdbx_total_number_of_bins_used ? _refine_ls_shell.pdbx_phase_error ? _refine_ls_shell.pdbx_fsc_work ? _refine_ls_shell.pdbx_fsc_free ? # loop_ _struct_ncs_dom.id _struct_ncs_dom.details _struct_ncs_dom.pdbx_ens_id 1 A 1 2 B 1 # loop_ _struct_ncs_dom_lim.dom_id _struct_ncs_dom_lim.beg_auth_asym_id _struct_ncs_dom_lim.beg_auth_seq_id _struct_ncs_dom_lim.end_auth_asym_id _struct_ncs_dom_lim.end_auth_seq_id _struct_ncs_dom_lim.pdbx_component_id _struct_ncs_dom_lim.pdbx_refine_code _struct_ncs_dom_lim.beg_label_asym_id _struct_ncs_dom_lim.beg_label_comp_id _struct_ncs_dom_lim.beg_label_seq_id _struct_ncs_dom_lim.beg_label_alt_id _struct_ncs_dom_lim.end_label_asym_id _struct_ncs_dom_lim.end_label_comp_id _struct_ncs_dom_lim.end_label_seq_id _struct_ncs_dom_lim.end_label_alt_id _struct_ncs_dom_lim.pdbx_ens_id _struct_ncs_dom_lim.selection_details 1 A 21 A 284 0 0 ? ? ? ? ? ? ? ? 1 ? 2 B 21 B 284 0 0 ? ? ? ? ? ? ? ? 1 ? # _struct_ncs_ens.id 1 _struct_ncs_ens.details ? # _struct.entry_id 5FBG _struct.title ;S1 nuclease from Aspergillus oryzae, mutant D65N, in complex with phosphate, 2'-deoxycytidine and 2'-deoxyguanosine. ; _struct.pdbx_descriptor 'Nuclease S1 (E.C.3.1.30.1)' _struct.pdbx_model_details ? _struct.pdbx_formula_weight ? _struct.pdbx_formula_weight_method ? _struct.pdbx_model_type_details ? _struct.pdbx_CASP_flag ? # _struct_keywords.entry_id 5FBG _struct_keywords.text 'Endonuclease, Zinc dependent, Complex, mutant, hydrolase' _struct_keywords.pdbx_keywords HYDROLASE # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 1 ? C N N 2 ? D N N 2 ? E N N 2 ? F N N 3 ? G N N 3 ? H N N 4 ? I N N 5 ? J N N 5 ? K N N 2 ? L N N 2 ? M N N 2 ? N N N 3 ? O N N 3 ? P N N 4 ? Q N N 6 ? R N N 7 ? S N N 7 ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 AA1 GLY A 2 ? VAL A 17 ? GLY A 22 VAL A 37 1 ? 16 HELX_P HELX_P2 AA2 ALA A 18 ? GLY A 30 ? ALA A 38 GLY A 50 1 ? 13 HELX_P HELX_P3 AA3 LEU A 37 ? ALA A 41 ? LEU A 57 ALA A 61 5 ? 5 HELX_P HELX_P4 AA4 THR A 42 ? TYR A 49 ? THR A 62 TYR A 69 1 ? 8 HELX_P HELX_P5 AA5 GLY A 53 ? PHE A 61 ? GLY A 73 PHE A 81 5 ? 9 HELX_P HELX_P6 AA6 ASP A 75 ? CYS A 80 ? ASP A 95 CYS A 100 1 ? 6 HELX_P HELX_P7 AA7 CYS A 85 ? SER A 100 ? CYS A 105 SER A 120 1 ? 16 HELX_P HELX_P8 AA8 GLU A 105 ? HIS A 121 ? GLU A 125 HIS A 141 1 ? 17 HELX_P HELX_P9 AA9 GLN A 122 ? GLU A 127 ? GLN A 142 GLU A 147 5 ? 6 HELX_P HELX_P10 AB1 ASN A 128 ? ASN A 134 ? ASN A 148 ASN A 154 1 ? 7 HELX_P HELX_P11 AB2 LEU A 147 ? THR A 153 ? LEU A 167 THR A 173 1 ? 7 HELX_P HELX_P12 AB3 THR A 153 ? GLY A 161 ? THR A 173 GLY A 181 1 ? 9 HELX_P HELX_P13 AB4 SER A 164 ? THR A 181 ? SER A 184 THR A 201 1 ? 18 HELX_P HELX_P14 AB5 LYS A 187 ? ASP A 193 ? LYS A 207 ASP A 213 5 ? 7 HELX_P HELX_P15 AB6 ASP A 199 ? THR A 218 ? ASP A 219 THR A 238 1 ? 20 HELX_P HELX_P16 AB7 GLY A 223 ? THR A 230 ? GLY A 243 THR A 250 1 ? 8 HELX_P HELX_P17 AB8 GLY A 234 ? SER A 264 ? GLY A 254 SER A 284 1 ? 31 HELX_P HELX_P18 AB9 GLY B 2 ? VAL B 17 ? GLY B 22 VAL B 37 1 ? 16 HELX_P HELX_P19 AC1 ALA B 18 ? GLY B 30 ? ALA B 38 GLY B 50 1 ? 13 HELX_P HELX_P20 AC2 LEU B 37 ? ALA B 41 ? LEU B 57 ALA B 61 5 ? 5 HELX_P HELX_P21 AC3 THR B 42 ? TYR B 49 ? THR B 62 TYR B 69 1 ? 8 HELX_P HELX_P22 AC4 GLY B 53 ? PHE B 61 ? GLY B 73 PHE B 81 5 ? 9 HELX_P HELX_P23 AC5 ASP B 75 ? CYS B 80 ? ASP B 95 CYS B 100 1 ? 6 HELX_P HELX_P24 AC6 CYS B 85 ? SER B 100 ? CYS B 105 SER B 120 1 ? 16 HELX_P HELX_P25 AC7 GLU B 105 ? HIS B 121 ? GLU B 125 HIS B 141 1 ? 17 HELX_P HELX_P26 AC8 GLN B 122 ? GLU B 127 ? GLN B 142 GLU B 147 5 ? 6 HELX_P HELX_P27 AC9 ASN B 128 ? GLY B 133 ? ASN B 148 GLY B 153 1 ? 6 HELX_P HELX_P28 AD1 LEU B 147 ? THR B 153 ? LEU B 167 THR B 173 1 ? 7 HELX_P HELX_P29 AD2 THR B 153 ? GLY B 161 ? THR B 173 GLY B 181 1 ? 9 HELX_P HELX_P30 AD3 SER B 164 ? THR B 181 ? SER B 184 THR B 201 1 ? 18 HELX_P HELX_P31 AD4 LYS B 187 ? ASP B 193 ? LYS B 207 ASP B 213 5 ? 7 HELX_P HELX_P32 AD5 ASP B 199 ? THR B 218 ? ASP B 219 THR B 238 1 ? 20 HELX_P HELX_P33 AD6 GLY B 223 ? THR B 230 ? GLY B 243 THR B 250 1 ? 8 HELX_P HELX_P34 AD7 GLY B 234 ? SER B 264 ? GLY B 254 SER B 284 1 ? 31 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 72 SG ? ? ? 1_555 A CYS 216 SG ? ? A CYS 92 A CYS 236 1_555 ? ? ? ? ? ? ? 2.071 ? disulf2 disulf ? ? A CYS 80 SG A ? ? 1_555 A CYS 85 SG ? ? A CYS 100 A CYS 105 1_555 ? ? ? ? ? ? ? 2.007 ? disulf3 disulf ? ? A CYS 80 SG B ? ? 1_555 A CYS 85 SG ? ? A CYS 100 A CYS 105 1_555 ? ? ? ? ? ? ? 2.686 ? disulf4 disulf ? ? B CYS 72 SG ? ? ? 1_555 B CYS 216 SG ? ? B CYS 92 B CYS 236 1_555 ? ? ? ? ? ? ? 2.037 ? disulf5 disulf ? ? B CYS 80 SG A ? ? 1_555 B CYS 85 SG ? ? B CYS 100 B CYS 105 1_555 ? ? ? ? ? ? ? 2.052 ? disulf6 disulf ? ? B CYS 80 SG B ? ? 1_555 B CYS 85 SG ? ? B CYS 100 B CYS 105 1_555 ? ? ? ? ? ? ? 2.788 ? metalc1 metalc ? ? A TRP 1 N ? ? ? 1_555 C ZN . ZN ? ? A TRP 21 A ZN 401 1_555 ? ? ? ? ? ? ? 2.147 ? metalc2 metalc ? ? A TRP 1 O ? ? ? 1_555 C ZN . ZN ? ? A TRP 21 A ZN 401 1_555 ? ? ? ? ? ? ? 2.167 ? metalc3 metalc ? ? A HIS 6 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 26 A ZN 401 1_555 ? ? ? ? ? ? ? 2.011 ? metalc4 metalc ? ? A ASN 45 OD1 ? ? ? 1_555 D ZN . ZN ? ? A ASN 65 A ZN 402 1_555 ? ? ? ? ? ? ? 2.590 ? metalc5 metalc ? ? A HIS 60 ND1 ? ? ? 1_555 D ZN . ZN ? ? A HIS 80 A ZN 402 1_555 ? ? ? ? ? ? ? 2.051 ? covale1 covale one ? A ASN 92 ND2 ? ? ? 1_555 F NAG . C1 ? ? A ASN 112 A NAG 501 1_555 ? ? ? ? ? ? ? 1.437 ? metalc6 metalc ? ? A HIS 115 NE2 ? ? ? 1_555 D ZN . ZN ? ? A HIS 135 A ZN 402 1_555 ? ? ? ? ? ? ? 2.123 ? metalc7 metalc ? ? A ASP 119 OD1 ? ? ? 1_555 C ZN . ZN ? ? A ASP 139 A ZN 401 1_555 ? ? ? ? ? ? ? 2.064 ? metalc8 metalc ? ? A ASP 119 OD2 ? ? ? 1_555 D ZN . ZN ? ? A ASP 139 A ZN 402 1_555 ? ? ? ? ? ? ? 2.140 ? metalc9 metalc ? ? A HIS 125 NE2 ? ? ? 1_555 E ZN . ZN ? ? A HIS 145 A ZN 403 1_555 ? ? ? ? ? ? ? 2.133 ? metalc10 metalc ? ? A HIS 148 NE2 ? ? ? 1_555 E ZN . ZN ? ? A HIS 168 A ZN 403 1_555 ? ? ? ? ? ? ? 2.113 ? metalc11 metalc ? ? A ASP 152 OD1 ? ? ? 1_555 E ZN . ZN ? ? A ASP 172 A ZN 403 1_555 ? ? ? ? ? ? ? 2.550 ? metalc12 metalc ? ? A ASP 152 OD2 ? ? ? 1_555 E ZN . ZN ? ? A ASP 172 A ZN 403 1_555 ? ? ? ? ? ? ? 2.063 ? covale2 covale one ? A ASN 228 ND2 ? ? ? 1_555 G NAG . C1 ? ? A ASN 248 A NAG 502 1_555 ? ? ? ? ? ? ? 1.469 ? metalc13 metalc ? ? B TRP 1 N ? ? ? 1_555 K ZN . ZN ? ? B TRP 21 B ZN 401 1_555 ? ? ? ? ? ? ? 2.134 ? metalc14 metalc ? ? B TRP 1 O ? ? ? 1_555 K ZN . ZN ? ? B TRP 21 B ZN 401 1_555 ? ? ? ? ? ? ? 2.171 ? metalc15 metalc ? ? B HIS 6 NE2 ? ? ? 1_555 K ZN . ZN ? ? B HIS 26 B ZN 401 1_555 ? ? ? ? ? ? ? 2.014 ? metalc16 metalc ? ? B HIS 60 ND1 ? ? ? 1_555 L ZN . ZN ? ? B HIS 80 B ZN 402 1_555 ? ? ? ? ? ? ? 2.093 ? covale3 covale one ? B ASN 92 ND2 ? ? ? 1_555 N NAG . C1 ? ? B ASN 112 B NAG 501 1_555 ? ? ? ? ? ? ? 1.471 ? metalc17 metalc ? ? B HIS 115 NE2 ? ? ? 1_555 L ZN . ZN ? ? B HIS 135 B ZN 402 1_555 ? ? ? ? ? ? ? 2.061 ? metalc18 metalc ? ? B ASP 119 OD1 ? ? ? 1_555 K ZN . ZN ? ? B ASP 139 B ZN 401 1_555 ? ? ? ? ? ? ? 2.045 ? metalc19 metalc ? ? B ASP 119 OD2 ? ? ? 1_555 L ZN . ZN ? ? B ASP 139 B ZN 402 1_555 ? ? ? ? ? ? ? 2.081 ? metalc20 metalc ? ? B HIS 125 NE2 ? ? ? 1_555 M ZN . ZN ? ? B HIS 145 B ZN 403 1_555 ? ? ? ? ? ? ? 2.169 ? metalc21 metalc ? ? B HIS 148 NE2 ? ? ? 1_555 M ZN . ZN ? ? B HIS 168 B ZN 403 1_555 ? ? ? ? ? ? ? 2.113 ? metalc22 metalc ? ? B ASP 152 OD1 ? ? ? 1_555 M ZN . ZN ? ? B ASP 172 B ZN 403 1_555 ? ? ? ? ? ? ? 2.657 ? metalc23 metalc ? ? B ASP 152 OD2 ? ? ? 1_555 M ZN . ZN ? ? B ASP 172 B ZN 403 1_555 ? ? ? ? ? ? ? 2.071 ? covale4 covale one ? B ASN 228 ND2 ? ? ? 1_555 O NAG . C1 ? ? B ASN 248 B NAG 502 1_555 ? ? ? ? ? ? ? 1.472 ? metalc24 metalc ? ? C ZN . ZN ? ? ? 1_555 H PO4 . O1 ? ? A ZN 401 A PO4 601 1_555 ? ? ? ? ? ? ? 1.811 ? metalc25 metalc ? ? D ZN . ZN ? ? ? 1_555 H PO4 . O1 ? ? A ZN 402 A PO4 601 1_555 ? ? ? ? ? ? ? 2.534 ? metalc26 metalc ? ? D ZN . ZN ? ? ? 1_555 H PO4 . O2 ? ? A ZN 402 A PO4 601 1_555 ? ? ? ? ? ? ? 2.091 ? metalc27 metalc ? ? E ZN . ZN ? ? ? 1_555 H PO4 . O3 ? ? A ZN 403 A PO4 601 1_555 ? ? ? ? ? ? ? 1.873 ? metalc28 metalc ? ? K ZN . ZN ? ? ? 1_555 P PO4 . O3 ? ? B ZN 401 B PO4 601 1_555 ? ? ? ? ? ? ? 1.994 ? metalc29 metalc ? ? L ZN . ZN ? ? ? 1_555 P PO4 . O1 ? ? B ZN 402 B PO4 601 1_555 ? ? ? ? ? ? ? 2.220 ? metalc30 metalc ? ? L ZN . ZN ? ? ? 1_555 P PO4 . O3 ? ? B ZN 402 B PO4 601 1_555 ? ? ? ? ? ? ? 2.084 ? metalc31 metalc ? ? M ZN . ZN ? ? ? 1_555 S HOH . O ? ? B ZN 403 B HOH 1034 1_555 ? ? ? ? ? ? ? 2.241 ? metalc32 metalc ? ? M ZN . ZN ? ? ? 1_555 P PO4 . O2 ? ? B ZN 403 B PO4 601 1_555 ? ? ? ? ? ? ? 2.037 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? metalc ? ? covale ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 PRO 68 A . ? PRO 88 A PRO 69 A ? PRO 89 A 1 1.84 2 PRO 68 B . ? PRO 88 B PRO 69 B ? PRO 89 B 1 3.16 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details AA1 ? 2 ? AA2 ? 2 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense AA1 1 2 ? anti-parallel AA2 1 2 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id AA1 1 ASP A 137 ? TYR A 140 ? ASP A 157 TYR A 160 AA1 2 GLU A 143 ? ASN A 146 ? GLU A 163 ASN A 166 AA2 1 ASP B 137 ? TYR B 140 ? ASP B 157 TYR B 160 AA2 2 GLU B 143 ? ASN B 146 ? GLU B 163 ASN B 166 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id AA1 1 2 N TYR A 140 ? N TYR A 160 O GLU A 143 ? O GLU A 163 AA2 1 2 N TYR B 140 ? N TYR B 160 O GLU B 143 ? O GLU B 163 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software A ZN 401 ? 5 'binding site for residue ZN A 401' AC2 Software A ZN 402 ? 6 'binding site for residue ZN A 402' AC3 Software A ZN 403 ? 4 'binding site for residue ZN A 403' AC4 Software A PO4 601 ? 15 'binding site for residue PO4 A 601' AC5 Software A DCZ 701 ? 13 'binding site for residue DCZ A 701' AC6 Software A DCZ 702 ? 5 'binding site for residue DCZ A 702' AC7 Software B ZN 401 ? 5 'binding site for residue ZN B 401' AC8 Software B ZN 402 ? 6 'binding site for residue ZN B 402' AC9 Software B ZN 403 ? 5 'binding site for residue ZN B 403' AD1 Software B PO4 601 ? 16 'binding site for residue PO4 B 601' AD2 Software B GNG 701 ? 14 'binding site for residue GNG B 701' AD3 Software A NAG 501 ? 9 'binding site for Mono-Saccharide NAG A 501 bound to ASN A 112' AD4 Software A NAG 502 ? 8 'binding site for Mono-Saccharide NAG A 502 bound to ASN A 248' AD5 Software B NAG 501 ? 7 'binding site for Mono-Saccharide NAG B 501 bound to ASN B 112' AD6 Software B NAG 502 ? 7 'binding site for Mono-Saccharide NAG B 502 bound to ASN B 248' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 5 TRP A 1 ? TRP A 21 . ? 1_555 ? 2 AC1 5 HIS A 6 ? HIS A 26 . ? 1_555 ? 3 AC1 5 ASP A 119 ? ASP A 139 . ? 1_555 ? 4 AC1 5 ZN D . ? ZN A 402 . ? 1_555 ? 5 AC1 5 PO4 H . ? PO4 A 601 . ? 1_555 ? 6 AC2 6 ASN A 45 ? ASN A 65 . ? 1_555 ? 7 AC2 6 HIS A 60 ? HIS A 80 . ? 1_555 ? 8 AC2 6 HIS A 115 ? HIS A 135 . ? 1_555 ? 9 AC2 6 ASP A 119 ? ASP A 139 . ? 1_555 ? 10 AC2 6 ZN C . ? ZN A 401 . ? 1_555 ? 11 AC2 6 PO4 H . ? PO4 A 601 . ? 1_555 ? 12 AC3 4 HIS A 125 ? HIS A 145 . ? 1_555 ? 13 AC3 4 HIS A 148 ? HIS A 168 . ? 1_555 ? 14 AC3 4 ASP A 152 ? ASP A 172 . ? 1_555 ? 15 AC3 4 PO4 H . ? PO4 A 601 . ? 1_555 ? 16 AC4 15 TRP A 1 ? TRP A 21 . ? 1_555 ? 17 AC4 15 HIS A 6 ? HIS A 26 . ? 1_555 ? 18 AC4 15 ASN A 45 ? ASN A 65 . ? 1_555 ? 19 AC4 15 LYS A 48 ? LYS A 68 . ? 1_555 ? 20 AC4 15 HIS A 60 ? HIS A 80 . ? 1_555 ? 21 AC4 15 HIS A 115 ? HIS A 135 . ? 1_555 ? 22 AC4 15 ASP A 119 ? ASP A 139 . ? 1_555 ? 23 AC4 15 HIS A 125 ? HIS A 145 . ? 1_555 ? 24 AC4 15 ASP A 152 ? ASP A 172 . ? 1_555 ? 25 AC4 15 ZN C . ? ZN A 401 . ? 1_555 ? 26 AC4 15 ZN D . ? ZN A 402 . ? 1_555 ? 27 AC4 15 ZN E . ? ZN A 403 . ? 1_555 ? 28 AC4 15 DCZ I . ? DCZ A 701 . ? 1_555 ? 29 AC4 15 HOH R . ? HOH A 1108 . ? 1_555 ? 30 AC4 15 HOH R . ? HOH A 1175 . ? 1_555 ? 31 AC5 13 LYS A 48 ? LYS A 68 . ? 1_555 ? 32 AC5 13 TYR A 49 ? TYR A 69 . ? 1_555 ? 33 AC5 13 PHE A 61 ? PHE A 81 . ? 1_555 ? 34 AC5 13 ASP A 63 ? ASP A 83 . ? 1_555 ? 35 AC5 13 HIS A 125 ? HIS A 145 . ? 1_555 ? 36 AC5 13 ALA A 131 ? ALA A 151 . ? 1_555 ? 37 AC5 13 ASN A 134 ? ASN A 154 . ? 1_555 ? 38 AC5 13 HIS A 148 ? HIS A 168 . ? 1_555 ? 39 AC5 13 PO4 H . ? PO4 A 601 . ? 1_555 ? 40 AC5 13 HOH R . ? HOH A 805 . ? 1_555 ? 41 AC5 13 HOH R . ? HOH A 1048 . ? 1_555 ? 42 AC5 13 HOH R . ? HOH A 1069 . ? 1_555 ? 43 AC5 13 HOH R . ? HOH A 1234 . ? 1_555 ? 44 AC6 5 GLU A 157 ? GLU A 177 . ? 1_555 ? 45 AC6 5 TYR A 163 ? TYR A 183 . ? 1_555 ? 46 AC6 5 HOH R . ? HOH A 1032 . ? 1_555 ? 47 AC6 5 LYS B 198 ? LYS B 218 . ? 1_555 ? 48 AC6 5 HOH S . ? HOH B 1118 . ? 1_555 ? 49 AC7 5 TRP B 1 ? TRP B 21 . ? 1_555 ? 50 AC7 5 HIS B 6 ? HIS B 26 . ? 1_555 ? 51 AC7 5 ASP B 119 ? ASP B 139 . ? 1_555 ? 52 AC7 5 ZN L . ? ZN B 402 . ? 1_555 ? 53 AC7 5 PO4 P . ? PO4 B 601 . ? 1_555 ? 54 AC8 6 ASN B 45 ? ASN B 65 . ? 1_555 ? 55 AC8 6 HIS B 60 ? HIS B 80 . ? 1_555 ? 56 AC8 6 HIS B 115 ? HIS B 135 . ? 1_555 ? 57 AC8 6 ASP B 119 ? ASP B 139 . ? 1_555 ? 58 AC8 6 ZN K . ? ZN B 401 . ? 1_555 ? 59 AC8 6 PO4 P . ? PO4 B 601 . ? 1_555 ? 60 AC9 5 HIS B 125 ? HIS B 145 . ? 1_555 ? 61 AC9 5 HIS B 148 ? HIS B 168 . ? 1_555 ? 62 AC9 5 ASP B 152 ? ASP B 172 . ? 1_555 ? 63 AC9 5 PO4 P . ? PO4 B 601 . ? 1_555 ? 64 AC9 5 HOH S . ? HOH B 1034 . ? 1_555 ? 65 AD1 16 HOH R . ? HOH A 1209 . ? 2_545 ? 66 AD1 16 TRP B 1 ? TRP B 21 . ? 1_555 ? 67 AD1 16 HIS B 6 ? HIS B 26 . ? 1_555 ? 68 AD1 16 ASN B 45 ? ASN B 65 . ? 1_555 ? 69 AD1 16 LYS B 48 ? LYS B 68 . ? 1_555 ? 70 AD1 16 HIS B 60 ? HIS B 80 . ? 1_555 ? 71 AD1 16 HIS B 115 ? HIS B 135 . ? 1_555 ? 72 AD1 16 ASP B 119 ? ASP B 139 . ? 1_555 ? 73 AD1 16 HIS B 125 ? HIS B 145 . ? 1_555 ? 74 AD1 16 ASP B 152 ? ASP B 172 . ? 1_555 ? 75 AD1 16 ZN K . ? ZN B 401 . ? 1_555 ? 76 AD1 16 ZN L . ? ZN B 402 . ? 1_555 ? 77 AD1 16 ZN M . ? ZN B 403 . ? 1_555 ? 78 AD1 16 HOH S . ? HOH B 1027 . ? 1_555 ? 79 AD1 16 HOH S . ? HOH B 1034 . ? 1_555 ? 80 AD1 16 HOH S . ? HOH B 1137 . ? 1_555 ? 81 AD2 14 GLY A 194 ? GLY A 214 . ? 5_544 ? 82 AD2 14 ILE A 206 ? ILE A 226 . ? 5_544 ? 83 AD2 14 PHE B 61 ? PHE B 81 . ? 1_555 ? 84 AD2 14 ASP B 63 ? ASP B 83 . ? 1_555 ? 85 AD2 14 HIS B 125 ? HIS B 145 . ? 1_555 ? 86 AD2 14 ALA B 131 ? ALA B 151 . ? 1_555 ? 87 AD2 14 GLY B 132 ? GLY B 152 . ? 1_555 ? 88 AD2 14 ASN B 134 ? ASN B 154 . ? 1_555 ? 89 AD2 14 HIS B 148 ? HIS B 168 . ? 1_555 ? 90 AD2 14 HOH S . ? HOH B 805 . ? 1_555 ? 91 AD2 14 HOH S . ? HOH B 1027 . ? 1_555 ? 92 AD2 14 HOH S . ? HOH B 1034 . ? 1_555 ? 93 AD2 14 HOH S . ? HOH B 1115 . ? 1_555 ? 94 AD2 14 HOH S . ? HOH B 1181 . ? 1_555 ? 95 AD3 9 PHE A 55 ? PHE A 75 . ? 1_555 ? 96 AD3 9 TYR A 59 ? TYR A 79 . ? 1_555 ? 97 AD3 9 ASN A 92 ? ASN A 112 . ? 1_555 ? 98 AD3 9 TYR A 93 ? TYR A 113 . ? 1_555 ? 99 AD3 9 GLU A 105 ? GLU A 125 . ? 1_555 ? 100 AD3 9 HOH R . ? HOH A 1006 . ? 1_555 ? 101 AD3 9 HOH R . ? HOH A 1040 . ? 1_555 ? 102 AD3 9 HOH R . ? HOH A 1164 . ? 1_555 ? 103 AD3 9 HOH R . ? HOH A 1179 . ? 1_555 ? 104 AD4 8 ASN A 228 ? ASN A 248 . ? 1_555 ? 105 AD4 8 HOH R . ? HOH A 1019 . ? 1_555 ? 106 AD4 8 HOH R . ? HOH A 1024 . ? 1_555 ? 107 AD4 8 HOH R . ? HOH A 1191 . ? 1_555 ? 108 AD4 8 HOH R . ? HOH A 1215 . ? 1_555 ? 109 AD4 8 GLU B 235 ? GLU B 255 . ? 4_545 ? 110 AD4 8 ASP B 238 ? ASP B 258 . ? 4_545 ? 111 AD4 8 HOH S . ? HOH B 1065 . ? 4_545 ? 112 AD5 7 PHE B 55 ? PHE B 75 . ? 1_555 ? 113 AD5 7 ASN B 92 ? ASN B 112 . ? 1_555 ? 114 AD5 7 TYR B 93 ? TYR B 113 . ? 1_555 ? 115 AD5 7 HOH S . ? HOH B 1032 . ? 1_555 ? 116 AD5 7 HOH S . ? HOH B 1070 . ? 1_555 ? 117 AD5 7 HOH S . ? HOH B 1071 . ? 1_555 ? 118 AD5 7 HOH S . ? HOH B 1217 . ? 1_555 ? 119 AD6 7 GLU B 177 ? GLU B 197 . ? 3_654 ? 120 AD6 7 LEU B 224 ? LEU B 244 . ? 1_555 ? 121 AD6 7 ALA B 225 ? ALA B 245 . ? 1_555 ? 122 AD6 7 ASN B 228 ? ASN B 248 . ? 1_555 ? 123 AD6 7 HOH S . ? HOH B 1012 . ? 1_555 ? 124 AD6 7 HOH S . ? HOH B 1093 . ? 1_555 ? 125 AD6 7 HOH S . ? HOH B 1122 . ? 1_555 ? # _atom_sites.entry_id 5FBG _atom_sites.fract_transf_matrix[1][1] 0.009367 _atom_sites.fract_transf_matrix[1][2] 0.005408 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] -0.000000 _atom_sites.fract_transf_matrix[2][2] 0.010816 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] -0.000000 _atom_sites.fract_transf_matrix[3][3] 0.007818 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C N O P S ZN # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . TRP A 1 1 ? 29.993 -55.090 -12.718 1.00 14.90 ? 21 TRP A N 1 ATOM 2 C CA . TRP A 1 1 ? 30.814 -56.233 -12.455 1.00 15.02 ? 21 TRP A CA 1 ATOM 3 C C . TRP A 1 1 ? 32.065 -55.795 -11.701 1.00 15.77 ? 21 TRP A C 1 ATOM 4 O O . TRP A 1 1 ? 32.497 -54.651 -11.814 1.00 14.34 ? 21 TRP A O 1 ATOM 5 C CB . TRP A 1 1 ? 31.233 -56.975 -13.724 1.00 15.05 ? 21 TRP A CB 1 ATOM 6 C CG . TRP A 1 1 ? 30.082 -57.318 -14.631 1.00 16.36 ? 21 TRP A CG 1 ATOM 7 C CD1 . TRP A 1 1 ? 29.741 -56.680 -15.754 1.00 15.67 ? 21 TRP A CD1 1 ATOM 8 C CD2 . TRP A 1 1 ? 29.125 -58.401 -14.461 1.00 15.74 ? 21 TRP A CD2 1 ATOM 9 N NE1 . TRP A 1 1 ? 28.667 -57.321 -16.347 1.00 16.10 ? 21 TRP A NE1 1 ATOM 10 C CE2 . TRP A 1 1 ? 28.281 -58.377 -15.565 1.00 16.57 ? 21 TRP A CE2 1 ATOM 11 C CE3 . TRP A 1 1 ? 28.938 -59.393 -13.485 1.00 16.41 ? 21 TRP A CE3 1 ATOM 12 C CZ2 . TRP A 1 1 ? 27.186 -59.281 -15.705 1.00 15.90 ? 21 TRP A CZ2 1 ATOM 13 C CZ3 . TRP A 1 1 ? 27.891 -60.304 -13.626 1.00 16.81 ? 21 TRP A CZ3 1 ATOM 14 C CH2 . TRP A 1 1 ? 27.024 -60.244 -14.726 1.00 15.21 ? 21 TRP A CH2 1 ATOM 15 N N . GLY A 1 2 ? 32.674 -56.789 -11.053 1.00 14.89 ? 22 GLY A N 1 ATOM 16 C CA . GLY A 1 2 ? 34.026 -56.660 -10.549 1.00 17.17 ? 22 GLY A CA 1 ATOM 17 C C . GLY A 1 2 ? 35.028 -56.828 -11.711 1.00 18.00 ? 22 GLY A C 1 ATOM 18 O O . GLY A 1 2 ? 34.659 -56.899 -12.888 1.00 15.70 ? 22 GLY A O 1 ATOM 19 N N . ASN A 1 3 ? 36.305 -56.859 -11.358 1.00 18.02 ? 23 ASN A N 1 ATOM 20 C CA . ASN A 1 3 ? 37.375 -56.857 -12.390 1.00 20.17 ? 23 ASN A CA 1 ATOM 21 C C . ASN A 1 3 ? 37.318 -58.062 -13.301 1.00 17.93 ? 23 ASN A C 1 ATOM 22 O O . ASN A 1 3 ? 37.433 -57.912 -14.483 1.00 18.04 ? 23 ASN A O 1 ATOM 23 C CB . ASN A 1 3 ? 38.743 -56.758 -11.725 1.00 22.65 ? 23 ASN A CB 1 ATOM 24 C CG . ASN A 1 3 ? 38.955 -55.389 -11.085 1.00 25.86 ? 23 ASN A CG 1 ATOM 25 O OD1 . ASN A 1 3 ? 38.119 -54.463 -11.190 1.00 30.09 ? 23 ASN A OD1 1 ATOM 26 N ND2 . ASN A 1 3 ? 40.061 -55.247 -10.424 1.00 31.16 ? 23 ASN A ND2 1 ATOM 27 N N . LEU A 1 4 ? 37.112 -59.237 -12.740 1.00 18.01 ? 24 LEU A N 1 ATOM 28 C CA . LEU A 1 4 ? 37.026 -60.452 -13.530 1.00 18.56 ? 24 LEU A CA 1 ATOM 29 C C . LEU A 1 4 ? 35.929 -60.344 -14.607 1.00 18.04 ? 24 LEU A C 1 ATOM 30 O O . LEU A 1 4 ? 36.174 -60.628 -15.797 1.00 16.16 ? 24 LEU A O 1 ATOM 31 C CB . LEU A 1 4 ? 36.792 -61.642 -12.618 1.00 20.73 ? 24 LEU A CB 1 ATOM 32 C CG . LEU A 1 4 ? 36.569 -63.074 -13.145 1.00 23.97 ? 24 LEU A CG 1 ATOM 33 C CD1 . LEU A 1 4 ? 35.203 -63.327 -13.743 1.00 26.02 ? 24 LEU A CD1 1 ATOM 34 C CD2 . LEU A 1 4 ? 37.697 -63.516 -14.075 1.00 23.35 ? 24 LEU A CD2 1 ATOM 35 N N . GLY A 1 5 ? 34.739 -59.910 -14.186 1.00 16.97 ? 25 GLY A N 1 ATOM 36 C CA . GLY A 1 5 ? 33.634 -59.752 -15.146 1.00 17.49 ? 25 GLY A CA 1 ATOM 37 C C . GLY A 1 5 ? 33.947 -58.786 -16.261 1.00 15.73 ? 25 GLY A C 1 ATOM 38 O O . GLY A 1 5 ? 33.739 -59.090 -17.424 1.00 16.48 ? 25 GLY A O 1 ATOM 39 N N . HIS A 1 6 ? 34.460 -57.608 -15.916 1.00 16.01 ? 26 HIS A N 1 ATOM 40 C CA . HIS A 1 6 ? 34.807 -56.615 -16.923 1.00 14.99 ? 26 HIS A CA 1 ATOM 41 C C . HIS A 1 6 ? 35.888 -57.111 -17.887 1.00 14.93 ? 26 HIS A C 1 ATOM 42 O O . HIS A 1 6 ? 35.795 -56.843 -19.075 1.00 15.74 ? 26 HIS A O 1 ATOM 43 C CB . HIS A 1 6 ? 35.240 -55.266 -16.324 1.00 16.31 ? 26 HIS A CB 1 ATOM 44 C CG . HIS A 1 6 ? 34.092 -54.505 -15.769 1.00 15.77 ? 26 HIS A CG 1 ATOM 45 N ND1 . HIS A 1 6 ? 33.188 -53.871 -16.573 1.00 16.28 ? 26 HIS A ND1 1 ATOM 46 C CD2 . HIS A 1 6 ? 33.645 -54.343 -14.488 1.00 16.75 ? 26 HIS A CD2 1 ATOM 47 C CE1 . HIS A 1 6 ? 32.211 -53.366 -15.827 1.00 15.55 ? 26 HIS A CE1 1 ATOM 48 N NE2 . HIS A 1 6 ? 32.464 -53.653 -14.568 1.00 15.61 ? 26 HIS A NE2 1 ATOM 49 N N . GLU A 1 7 ? 36.869 -57.813 -17.358 1.00 14.17 ? 27 GLU A N 1 ATOM 50 C CA . GLU A 1 7 ? 37.996 -58.292 -18.196 1.00 15.65 ? 27 GLU A CA 1 ATOM 51 C C . GLU A 1 7 ? 37.515 -59.432 -19.124 1.00 17.47 ? 27 GLU A C 1 ATOM 52 O O . GLU A 1 7 ? 37.932 -59.544 -20.286 1.00 17.22 ? 27 GLU A O 1 ATOM 53 C CB . GLU A 1 7 ? 39.127 -58.748 -17.317 1.00 15.78 ? 27 GLU A CB 1 ATOM 54 C CG . GLU A 1 7 ? 39.819 -57.581 -16.647 1.00 17.27 ? 27 GLU A CG 1 ATOM 55 C CD . GLU A 1 7 ? 40.604 -57.962 -15.387 1.00 20.07 ? 27 GLU A CD 1 ATOM 56 O OE1 . GLU A 1 7 ? 40.622 -59.158 -14.948 1.00 21.60 ? 27 GLU A OE1 1 ATOM 57 O OE2 . GLU A 1 7 ? 41.167 -57.001 -14.829 1.00 20.79 ? 27 GLU A OE2 1 ATOM 58 N N . THR A 1 8 ? 36.629 -60.266 -18.587 1.00 17.46 ? 28 THR A N 1 ATOM 59 C CA . THR A 1 8 ? 35.965 -61.286 -19.396 1.00 17.86 ? 28 THR A CA 1 ATOM 60 C C . THR A 1 8 ? 35.178 -60.686 -20.544 1.00 16.58 ? 28 THR A C 1 ATOM 61 O O . THR A 1 8 ? 35.314 -61.116 -21.681 1.00 17.47 ? 28 THR A O 1 ATOM 62 C CB . THR A 1 8 ? 35.073 -62.187 -18.509 1.00 18.34 ? 28 THR A CB 1 ATOM 63 O OG1 . THR A 1 8 ? 35.885 -62.778 -17.504 1.00 15.70 ? 28 THR A OG1 1 ATOM 64 C CG2 . THR A 1 8 ? 34.452 -63.293 -19.353 1.00 19.86 ? 28 THR A CG2 1 ATOM 65 N N . VAL A 1 9 ? 34.322 -59.694 -20.235 1.00 17.17 ? 29 VAL A N 1 ATOM 66 C CA . VAL A 1 9 ? 33.548 -59.040 -21.257 1.00 16.48 ? 29 VAL A CA 1 ATOM 67 C C . VAL A 1 9 ? 34.522 -58.535 -22.364 1.00 15.72 ? 29 VAL A C 1 ATOM 68 O O . VAL A 1 9 ? 34.275 -58.695 -23.568 1.00 15.45 ? 29 VAL A O 1 ATOM 69 C CB . VAL A 1 9 ? 32.711 -57.882 -20.669 1.00 15.75 ? 29 VAL A CB 1 ATOM 70 C CG1 . VAL A 1 9 ? 32.175 -56.952 -21.733 1.00 15.18 ? 29 VAL A CG1 1 ATOM 71 C CG2 . VAL A 1 9 ? 31.577 -58.444 -19.862 1.00 16.69 ? 29 VAL A CG2 1 ATOM 72 N N . ALA A 1 10 ? 35.584 -57.876 -21.938 1.00 14.01 ? 30 ALA A N 1 ATOM 73 C CA . ALA A 1 10 ? 36.535 -57.245 -22.874 1.00 14.47 ? 30 ALA A CA 1 ATOM 74 C C . ALA A 1 10 ? 37.264 -58.296 -23.746 1.00 15.17 ? 30 ALA A C 1 ATOM 75 O O . ALA A 1 10 ? 37.433 -58.081 -24.943 1.00 15.03 ? 30 ALA A O 1 ATOM 76 C CB . ALA A 1 10 ? 37.566 -56.404 -22.102 1.00 14.56 ? 30 ALA A CB 1 ATOM 77 N N . TYR A 1 11 ? 37.652 -59.430 -23.154 1.00 16.18 ? 31 TYR A N 1 ATOM 78 C CA . TYR A 1 11 ? 38.332 -60.480 -23.950 1.00 17.82 ? 31 TYR A CA 1 ATOM 79 C C . TYR A 1 11 ? 37.364 -61.102 -24.971 1.00 18.22 ? 31 TYR A C 1 ATOM 80 O O . TYR A 1 11 ? 37.738 -61.400 -26.101 1.00 17.60 ? 31 TYR A O 1 ATOM 81 C CB . TYR A 1 11 ? 38.907 -61.552 -23.057 1.00 19.04 ? 31 TYR A CB 1 ATOM 82 C CG . TYR A 1 11 ? 40.276 -61.258 -22.468 1.00 19.74 ? 31 TYR A CG 1 ATOM 83 C CD1 . TYR A 1 11 ? 41.375 -60.958 -23.288 1.00 20.09 ? 31 TYR A CD1 1 ATOM 84 C CD2 . TYR A 1 11 ? 40.502 -61.401 -21.091 1.00 19.44 ? 31 TYR A CD2 1 ATOM 85 C CE1 . TYR A 1 11 ? 42.640 -60.738 -22.739 1.00 20.99 ? 31 TYR A CE1 1 ATOM 86 C CE2 . TYR A 1 11 ? 41.749 -61.199 -20.545 1.00 20.28 ? 31 TYR A CE2 1 ATOM 87 C CZ . TYR A 1 11 ? 42.814 -60.864 -21.363 1.00 21.78 ? 31 TYR A CZ 1 ATOM 88 O OH . TYR A 1 11 ? 44.051 -60.675 -20.796 1.00 22.93 ? 31 TYR A OH 1 ATOM 89 N N . ILE A 1 12 ? 36.103 -61.228 -24.594 1.00 17.34 ? 32 ILE A N 1 ATOM 90 C CA . ILE A 1 12 ? 35.093 -61.712 -25.544 1.00 16.60 ? 32 ILE A CA 1 ATOM 91 C C . ILE A 1 12 ? 34.980 -60.728 -26.714 1.00 16.41 ? 32 ILE A C 1 ATOM 92 O O . ILE A 1 12 ? 35.039 -61.113 -27.889 1.00 19.09 ? 32 ILE A O 1 ATOM 93 C CB . ILE A 1 12 ? 33.715 -61.933 -24.896 1.00 16.20 ? 32 ILE A CB 1 ATOM 94 C CG1 . ILE A 1 12 ? 33.822 -63.047 -23.868 1.00 16.68 ? 32 ILE A CG1 1 ATOM 95 C CG2 . ILE A 1 12 ? 32.666 -62.329 -25.949 1.00 16.43 ? 32 ILE A CG2 1 ATOM 96 C CD1 . ILE A 1 12 ? 32.634 -63.202 -22.923 1.00 16.39 ? 32 ILE A CD1 1 ATOM 97 N N . ALA A 1 13 ? 34.852 -59.458 -26.398 1.00 16.93 ? 33 ALA A N 1 ATOM 98 C CA . ALA A 1 13 ? 34.798 -58.463 -27.456 1.00 16.13 ? 33 ALA A CA 1 ATOM 99 C C . ALA A 1 13 ? 36.012 -58.546 -28.369 1.00 17.77 ? 33 ALA A C 1 ATOM 100 O O . ALA A 1 13 ? 35.855 -58.477 -29.601 1.00 19.28 ? 33 ALA A O 1 ATOM 101 C CB . ALA A 1 13 ? 34.627 -57.065 -26.943 1.00 15.04 ? 33 ALA A CB 1 ATOM 102 N N . GLN A 1 14 ? 37.206 -58.665 -27.785 1.00 19.28 ? 34 GLN A N 1 ATOM 103 C CA . GLN A 1 14 ? 38.447 -58.794 -28.617 1.00 20.08 ? 34 GLN A CA 1 ATOM 104 C C . GLN A 1 14 ? 38.373 -59.982 -29.592 1.00 19.99 ? 34 GLN A C 1 ATOM 105 O O . GLN A 1 14 ? 38.851 -59.869 -30.709 1.00 19.60 ? 34 GLN A O 1 ATOM 106 C CB . GLN A 1 14 ? 39.711 -58.951 -27.790 1.00 20.56 ? 34 GLN A CB 1 ATOM 107 C CG . GLN A 1 14 ? 40.088 -57.753 -26.908 1.00 19.74 ? 34 GLN A CG 1 ATOM 108 C CD . GLN A 1 14 ? 41.363 -57.953 -26.078 1.00 20.18 ? 34 GLN A CD 1 ATOM 109 O OE1 . GLN A 1 14 ? 41.610 -57.206 -25.127 1.00 19.03 ? 34 GLN A OE1 1 ATOM 110 N NE2 . GLN A 1 14 ? 42.154 -58.970 -26.397 1.00 21.48 ? 34 GLN A NE2 1 ATOM 111 N N . SER A 1 15 ? 37.749 -61.083 -29.166 1.00 20.84 ? 35 SER A N 1 ATOM 112 C CA . SER A 1 15 ? 37.539 -62.234 -30.043 1.00 22.25 ? 35 SER A CA 1 ATOM 113 C C . SER A 1 15 ? 36.543 -62.031 -31.200 1.00 23.58 ? 35 SER A C 1 ATOM 114 O O . SER A 1 15 ? 36.560 -62.818 -32.126 1.00 24.69 ? 35 SER A O 1 ATOM 115 C CB . SER A 1 15 ? 37.100 -63.462 -29.287 1.00 22.78 ? 35 SER A CB 1 ATOM 116 O OG . SER A 1 15 ? 38.042 -63.864 -28.338 1.00 21.64 ? 35 SER A OG 1 ATOM 117 N N . PHE A 1 16 ? 35.703 -61.003 -31.168 1.00 20.98 ? 36 PHE A N 1 ATOM 118 C CA . PHE A 1 16 ? 34.699 -60.806 -32.209 1.00 21.27 ? 36 PHE A CA 1 ATOM 119 C C . PHE A 1 16 ? 34.874 -59.577 -33.079 1.00 21.86 ? 36 PHE A C 1 ATOM 120 O O . PHE A 1 16 ? 34.266 -59.509 -34.140 1.00 23.42 ? 36 PHE A O 1 ATOM 121 C CB . PHE A 1 16 ? 33.253 -60.825 -31.624 1.00 20.26 ? 36 PHE A CB 1 ATOM 122 C CG . PHE A 1 16 ? 32.830 -62.175 -31.199 1.00 19.01 ? 36 PHE A CG 1 ATOM 123 C CD1 . PHE A 1 16 ? 32.289 -63.081 -32.144 1.00 20.57 ? 36 PHE A CD1 1 ATOM 124 C CD2 . PHE A 1 16 ? 33.018 -62.593 -29.906 1.00 18.27 ? 36 PHE A CD2 1 ATOM 125 C CE1 . PHE A 1 16 ? 31.960 -64.378 -31.758 1.00 19.23 ? 36 PHE A CE1 1 ATOM 126 C CE2 . PHE A 1 16 ? 32.695 -63.871 -29.500 1.00 18.71 ? 36 PHE A CE2 1 ATOM 127 C CZ . PHE A 1 16 ? 32.144 -64.765 -30.429 1.00 19.80 ? 36 PHE A CZ 1 ATOM 128 N N . VAL A 1 17 ? 35.690 -58.596 -32.666 1.00 18.73 ? 37 VAL A N 1 ATOM 129 C CA . VAL A 1 17 ? 35.829 -57.382 -33.484 1.00 17.42 ? 37 VAL A CA 1 ATOM 130 C C . VAL A 1 17 ? 36.619 -57.704 -34.752 1.00 18.65 ? 37 VAL A C 1 ATOM 131 O O . VAL A 1 17 ? 37.410 -58.649 -34.759 1.00 19.77 ? 37 VAL A O 1 ATOM 132 C CB . VAL A 1 17 ? 36.542 -56.210 -32.750 1.00 17.71 ? 37 VAL A CB 1 ATOM 133 C CG1 . VAL A 1 17 ? 35.692 -55.698 -31.602 1.00 17.89 ? 37 VAL A CG1 1 ATOM 134 C CG2 . VAL A 1 17 ? 37.957 -56.596 -32.271 1.00 16.90 ? 37 VAL A CG2 1 ATOM 135 N N . ALA A 1 18 ? 36.396 -56.901 -35.781 1.00 20.13 ? 38 ALA A N 1 ATOM 136 C CA . ALA A 1 18 ? 37.175 -56.939 -37.012 1.00 21.89 ? 38 ALA A CA 1 ATOM 137 C C . ALA A 1 18 ? 38.631 -56.439 -36.760 1.00 24.93 ? 38 ALA A C 1 ATOM 138 O O . ALA A 1 18 ? 38.891 -55.680 -35.795 1.00 22.56 ? 38 ALA A O 1 ATOM 139 C CB . ALA A 1 18 ? 36.512 -56.082 -38.076 1.00 21.38 ? 38 ALA A CB 1 ATOM 140 N N . SER A 1 19 ? 39.550 -56.831 -37.649 1.00 23.36 ? 39 SER A N 1 ATOM 141 C CA . SER A 1 19 ? 40.937 -56.471 -37.480 1.00 24.15 ? 39 SER A CA 1 ATOM 142 C C . SER A 1 19 ? 41.115 -54.959 -37.531 1.00 21.18 ? 39 SER A C 1 ATOM 143 O O . SER A 1 19 ? 41.915 -54.425 -36.781 1.00 20.82 ? 39 SER A O 1 ATOM 144 C CB A SER A 1 19 ? 41.810 -57.158 -38.555 0.50 24.92 ? 39 SER A CB 1 ATOM 145 C CB B SER A 1 19 ? 41.854 -57.135 -38.540 0.50 24.42 ? 39 SER A CB 1 ATOM 146 O OG A SER A 1 19 ? 41.370 -56.802 -39.848 0.50 24.85 ? 39 SER A OG 1 ATOM 147 O OG B SER A 1 19 ? 41.612 -58.506 -38.587 0.50 23.34 ? 39 SER A OG 1 ATOM 148 N N . SER A 1 20 ? 40.355 -54.279 -38.382 1.00 19.61 ? 40 SER A N 1 ATOM 149 C CA . SER A 1 20 ? 40.475 -52.851 -38.452 1.00 21.94 ? 40 SER A CA 1 ATOM 150 C C . SER A 1 20 ? 39.936 -52.161 -37.147 1.00 22.00 ? 40 SER A C 1 ATOM 151 O O . SER A 1 20 ? 40.369 -51.052 -36.795 1.00 20.49 ? 40 SER A O 1 ATOM 152 C CB . SER A 1 20 ? 39.732 -52.292 -39.659 1.00 23.33 ? 40 SER A CB 1 ATOM 153 O OG . SER A 1 20 ? 38.402 -52.755 -39.630 1.00 27.12 ? 40 SER A OG 1 ATOM 154 N N . THR A 1 21 ? 38.951 -52.804 -36.518 1.00 20.60 ? 41 THR A N 1 ATOM 155 C CA . THR A 1 21 ? 38.370 -52.300 -35.247 1.00 21.22 ? 41 THR A CA 1 ATOM 156 C C . THR A 1 21 ? 39.439 -52.450 -34.137 1.00 19.87 ? 41 THR A C 1 ATOM 157 O O . THR A 1 21 ? 39.680 -51.534 -33.353 1.00 18.48 ? 41 THR A O 1 ATOM 158 C CB . THR A 1 21 ? 37.078 -53.063 -34.872 1.00 19.98 ? 41 THR A CB 1 ATOM 159 O OG1 . THR A 1 21 ? 36.084 -52.903 -35.911 1.00 20.87 ? 41 THR A OG1 1 ATOM 160 C CG2 . THR A 1 21 ? 36.495 -52.536 -33.523 1.00 18.70 ? 41 THR A CG2 1 ATOM 161 N N . GLU A 1 22 ? 40.103 -53.601 -34.140 1.00 20.67 ? 42 GLU A N 1 ATOM 162 C CA . GLU A 1 22 ? 41.229 -53.853 -33.248 1.00 22.50 ? 42 GLU A CA 1 ATOM 163 C C . GLU A 1 22 ? 42.285 -52.765 -33.338 1.00 22.13 ? 42 GLU A C 1 ATOM 164 O O . GLU A 1 22 ? 42.674 -52.191 -32.314 1.00 21.34 ? 42 GLU A O 1 ATOM 165 C CB . GLU A 1 22 ? 41.822 -55.227 -33.477 1.00 23.19 ? 42 GLU A CB 1 ATOM 166 C CG . GLU A 1 22 ? 43.107 -55.478 -32.731 1.00 27.15 ? 42 GLU A CG 1 ATOM 167 C CD . GLU A 1 22 ? 43.694 -56.874 -32.946 1.00 32.08 ? 42 GLU A CD 1 ATOM 168 O OE1 . GLU A 1 22 ? 43.087 -57.715 -33.600 1.00 38.45 ? 42 GLU A OE1 1 ATOM 169 O OE2 . GLU A 1 22 ? 44.762 -57.146 -32.410 1.00 40.94 ? 42 GLU A OE2 1 ATOM 170 N N . SER A 1 23 ? 42.701 -52.417 -34.548 1.00 21.84 ? 43 SER A N 1 ATOM 171 C CA . SER A 1 23 ? 43.693 -51.377 -34.730 1.00 20.91 ? 43 SER A CA 1 ATOM 172 C C . SER A 1 23 ? 43.216 -50.060 -34.307 1.00 18.70 ? 43 SER A C 1 ATOM 173 O O . SER A 1 23 ? 43.974 -49.298 -33.688 1.00 17.53 ? 43 SER A O 1 ATOM 174 C CB . SER A 1 23 ? 44.141 -51.247 -36.217 1.00 24.67 ? 43 SER A CB 1 ATOM 175 O OG . SER A 1 23 ? 44.560 -52.519 -36.623 1.00 31.53 ? 43 SER A OG 1 ATOM 176 N N . PHE A 1 24 ? 41.989 -49.745 -34.686 1.00 17.64 ? 44 PHE A N 1 ATOM 177 C CA . PHE A 1 24 ? 41.325 -48.481 -34.261 1.00 17.72 ? 44 PHE A CA 1 ATOM 178 C C . PHE A 1 24 ? 41.371 -48.286 -32.705 1.00 16.32 ? 44 PHE A C 1 ATOM 179 O O . PHE A 1 24 ? 41.782 -47.221 -32.220 1.00 15.80 ? 44 PHE A O 1 ATOM 180 C CB . PHE A 1 24 ? 39.892 -48.499 -34.759 1.00 19.63 ? 44 PHE A CB 1 ATOM 181 C CG . PHE A 1 24 ? 39.052 -47.334 -34.319 1.00 22.03 ? 44 PHE A CG 1 ATOM 182 C CD1 . PHE A 1 24 ? 39.056 -46.152 -35.051 1.00 23.83 ? 44 PHE A CD1 1 ATOM 183 C CD2 . PHE A 1 24 ? 38.188 -47.443 -33.220 1.00 22.95 ? 44 PHE A CD2 1 ATOM 184 C CE1 . PHE A 1 24 ? 38.205 -45.086 -34.715 1.00 24.72 ? 44 PHE A CE1 1 ATOM 185 C CE2 . PHE A 1 24 ? 37.364 -46.375 -32.871 1.00 25.10 ? 44 PHE A CE2 1 ATOM 186 C CZ . PHE A 1 24 ? 37.367 -45.200 -33.620 1.00 25.75 ? 44 PHE A CZ 1 ATOM 187 N N . CYS A 1 25 ? 41.021 -49.345 -31.971 1.00 15.64 ? 45 CYS A N 1 ATOM 188 C CA . CYS A 1 25 ? 41.062 -49.319 -30.496 1.00 17.15 ? 45 CYS A CA 1 ATOM 189 C C . CYS A 1 25 ? 42.512 -49.236 -29.934 1.00 18.62 ? 45 CYS A C 1 ATOM 190 O O . CYS A 1 25 ? 42.809 -48.414 -29.098 1.00 19.39 ? 45 CYS A O 1 ATOM 191 C CB . CYS A 1 25 ? 40.322 -50.523 -29.929 1.00 16.77 ? 45 CYS A CB 1 ATOM 192 S SG . CYS A 1 25 ? 38.551 -50.518 -30.321 1.00 19.90 ? 45 CYS A SG 1 ATOM 193 N N . GLN A 1 26 ? 43.404 -50.099 -30.414 1.00 20.22 ? 46 GLN A N 1 ATOM 194 C CA . GLN A 1 26 ? 44.790 -50.093 -29.970 1.00 19.89 ? 46 GLN A CA 1 ATOM 195 C C . GLN A 1 26 ? 45.423 -48.714 -30.162 1.00 20.69 ? 46 GLN A C 1 ATOM 196 O O . GLN A 1 26 ? 46.093 -48.208 -29.237 1.00 19.13 ? 46 GLN A O 1 ATOM 197 C CB . GLN A 1 26 ? 45.619 -51.171 -30.663 1.00 20.62 ? 46 GLN A CB 1 ATOM 198 C CG . GLN A 1 26 ? 45.243 -52.571 -30.221 1.00 21.72 ? 46 GLN A CG 1 ATOM 199 C CD . GLN A 1 26 ? 45.960 -53.677 -31.025 1.00 24.08 ? 46 GLN A CD 1 ATOM 200 O OE1 . GLN A 1 26 ? 46.319 -53.474 -32.180 1.00 27.60 ? 46 GLN A OE1 1 ATOM 201 N NE2 . GLN A 1 26 ? 46.067 -54.834 -30.458 1.00 23.88 ? 46 GLN A NE2 1 ATOM 202 N N . ASN A 1 27 ? 45.160 -48.070 -31.299 1.00 21.21 ? 47 ASN A N 1 ATOM 203 C CA . ASN A 1 27 ? 45.687 -46.691 -31.511 1.00 22.79 ? 47 ASN A CA 1 ATOM 204 C C . ASN A 1 27 ? 45.130 -45.710 -30.470 1.00 22.44 ? 47 ASN A C 1 ATOM 205 O O . ASN A 1 27 ? 45.880 -44.905 -29.886 1.00 20.26 ? 47 ASN A O 1 ATOM 206 C CB A ASN A 1 27 ? 45.512 -46.226 -32.976 0.50 22.83 ? 47 ASN A CB 1 ATOM 207 C CB B ASN A 1 27 ? 45.391 -46.123 -32.916 0.50 22.12 ? 47 ASN A CB 1 ATOM 208 C CG A ASN A 1 27 ? 46.194 -47.161 -33.992 0.50 24.04 ? 47 ASN A CG 1 ATOM 209 C CG B ASN A 1 27 ? 45.750 -44.600 -33.039 0.50 23.35 ? 47 ASN A CG 1 ATOM 210 O OD1 A ASN A 1 27 ? 46.961 -48.047 -33.650 0.50 24.29 ? 47 ASN A OD1 1 ATOM 211 O OD1 B ASN A 1 27 ? 44.878 -43.738 -33.284 0.50 20.61 ? 47 ASN A OD1 1 ATOM 212 N ND2 A ASN A 1 27 ? 45.866 -46.971 -35.262 0.50 26.37 ? 47 ASN A ND2 1 ATOM 213 N ND2 B ASN A 1 27 ? 47.044 -44.270 -32.856 0.50 23.09 ? 47 ASN A ND2 1 ATOM 214 N N . ILE A 1 28 ? 43.808 -45.757 -30.254 1.00 21.71 ? 48 ILE A N 1 ATOM 215 C CA . ILE A 1 28 ? 43.183 -44.798 -29.325 1.00 19.42 ? 48 ILE A CA 1 ATOM 216 C C . ILE A 1 28 ? 43.726 -45.024 -27.900 1.00 19.07 ? 48 ILE A C 1 ATOM 217 O O . ILE A 1 28 ? 43.986 -44.051 -27.187 1.00 18.88 ? 48 ILE A O 1 ATOM 218 C CB . ILE A 1 28 ? 41.645 -44.851 -29.373 1.00 20.56 ? 48 ILE A CB 1 ATOM 219 C CG1 . ILE A 1 28 ? 41.132 -44.152 -30.642 1.00 21.86 ? 48 ILE A CG1 1 ATOM 220 C CG2 . ILE A 1 28 ? 41.016 -44.200 -28.125 1.00 19.76 ? 48 ILE A CG2 1 ATOM 221 C CD1 . ILE A 1 28 ? 39.732 -44.537 -31.083 1.00 23.48 ? 48 ILE A CD1 1 ATOM 222 N N . LEU A 1 29 ? 43.878 -46.290 -27.521 1.00 18.02 ? 49 LEU A N 1 ATOM 223 C CA . LEU A 1 29 ? 44.311 -46.662 -26.176 1.00 18.44 ? 49 LEU A CA 1 ATOM 224 C C . LEU A 1 29 ? 45.793 -46.548 -25.908 1.00 18.77 ? 49 LEU A C 1 ATOM 225 O O . LEU A 1 29 ? 46.236 -46.588 -24.741 1.00 16.01 ? 49 LEU A O 1 ATOM 226 C CB . LEU A 1 29 ? 43.862 -48.093 -25.837 1.00 18.03 ? 49 LEU A CB 1 ATOM 227 C CG . LEU A 1 29 ? 42.330 -48.305 -25.818 1.00 17.48 ? 49 LEU A CG 1 ATOM 228 C CD1 . LEU A 1 29 ? 42.013 -49.772 -25.679 1.00 18.09 ? 49 LEU A CD1 1 ATOM 229 C CD2 . LEU A 1 29 ? 41.681 -47.498 -24.710 1.00 16.27 ? 49 LEU A CD2 1 ATOM 230 N N . GLY A 1 30 ? 46.572 -46.471 -26.983 1.00 19.20 ? 50 GLY A N 1 ATOM 231 C CA . GLY A 1 30 ? 48.025 -46.577 -26.884 1.00 18.75 ? 50 GLY A CA 1 ATOM 232 C C . GLY A 1 30 ? 48.448 -47.862 -26.234 1.00 19.18 ? 50 GLY A C 1 ATOM 233 O O . GLY A 1 30 ? 49.404 -47.914 -25.440 1.00 19.97 ? 50 GLY A O 1 ATOM 234 N N . ASP A 1 31 ? 47.791 -48.937 -26.607 1.00 19.87 ? 51 ASP A N 1 ATOM 235 C CA . ASP A 1 31 ? 48.090 -50.266 -26.043 1.00 20.00 ? 51 ASP A CA 1 ATOM 236 C C . ASP A 1 31 ? 47.888 -51.256 -27.169 1.00 22.20 ? 51 ASP A C 1 ATOM 237 O O . ASP A 1 31 ? 46.758 -51.467 -27.652 1.00 22.33 ? 51 ASP A O 1 ATOM 238 C CB . ASP A 1 31 ? 47.187 -50.542 -24.839 1.00 19.06 ? 51 ASP A CB 1 ATOM 239 C CG . ASP A 1 31 ? 47.412 -51.918 -24.180 1.00 18.50 ? 51 ASP A CG 1 ATOM 240 O OD1 . ASP A 1 31 ? 47.849 -52.872 -24.854 1.00 19.38 ? 51 ASP A OD1 1 ATOM 241 O OD2 . ASP A 1 31 ? 47.174 -52.074 -22.930 1.00 18.15 ? 51 ASP A OD2 1 ATOM 242 N N . ASP A 1 32 ? 48.970 -51.856 -27.644 1.00 22.70 ? 52 ASP A N 1 ATOM 243 C CA . ASP A 1 32 ? 48.800 -52.837 -28.719 1.00 25.09 ? 52 ASP A CA 1 ATOM 244 C C . ASP A 1 32 ? 49.100 -54.243 -28.261 1.00 22.90 ? 52 ASP A C 1 ATOM 245 O O . ASP A 1 32 ? 49.361 -55.136 -29.060 1.00 22.36 ? 52 ASP A O 1 ATOM 246 C CB . ASP A 1 32 ? 49.557 -52.451 -29.986 1.00 31.29 ? 52 ASP A CB 1 ATOM 247 C CG . ASP A 1 32 ? 51.009 -52.348 -29.781 1.00 34.77 ? 52 ASP A CG 1 ATOM 248 O OD1 . ASP A 1 32 ? 51.501 -52.747 -28.700 1.00 35.78 ? 52 ASP A OD1 1 ATOM 249 O OD2 . ASP A 1 32 ? 51.656 -51.794 -30.703 1.00 47.94 ? 52 ASP A OD2 1 ATOM 250 N N . SER A 1 33 ? 48.971 -54.472 -26.979 1.00 19.62 ? 53 SER A N 1 ATOM 251 C CA . SER A 1 33 ? 49.063 -55.847 -26.505 1.00 20.30 ? 53 SER A CA 1 ATOM 252 C C . SER A 1 33 ? 47.872 -56.724 -26.930 1.00 20.61 ? 53 SER A C 1 ATOM 253 O O . SER A 1 33 ? 46.848 -56.260 -27.405 1.00 22.55 ? 53 SER A O 1 ATOM 254 C CB . SER A 1 33 ? 49.200 -55.860 -24.977 1.00 21.62 ? 53 SER A CB 1 ATOM 255 O OG . SER A 1 33 ? 47.973 -55.506 -24.355 1.00 21.38 ? 53 SER A OG 1 ATOM 256 N N . THR A 1 34 ? 47.999 -57.999 -26.674 1.00 21.05 ? 54 THR A N 1 ATOM 257 C CA . THR A 1 34 ? 46.915 -58.935 -26.890 1.00 22.67 ? 54 THR A CA 1 ATOM 258 C C . THR A 1 34 ? 45.859 -58.860 -25.757 1.00 22.80 ? 54 THR A C 1 ATOM 259 O O . THR A 1 34 ? 44.926 -59.648 -25.711 1.00 22.53 ? 54 THR A O 1 ATOM 260 C CB . THR A 1 34 ? 47.465 -60.361 -26.961 1.00 23.19 ? 54 THR A CB 1 ATOM 261 O OG1 . THR A 1 34 ? 48.217 -60.604 -25.796 1.00 24.37 ? 54 THR A OG1 1 ATOM 262 C CG2 . THR A 1 34 ? 48.363 -60.539 -28.181 1.00 25.20 ? 54 THR A CG2 1 ATOM 263 N N . SER A 1 35 ? 46.022 -57.912 -24.824 1.00 23.04 ? 55 SER A N 1 ATOM 264 C CA . SER A 1 35 ? 45.009 -57.673 -23.787 1.00 19.49 ? 55 SER A CA 1 ATOM 265 C C . SER A 1 35 ? 44.507 -56.250 -23.828 1.00 18.44 ? 55 SER A C 1 ATOM 266 O O . SER A 1 35 ? 43.943 -55.724 -22.846 1.00 19.85 ? 55 SER A O 1 ATOM 267 C CB . SER A 1 35 ? 45.642 -57.936 -22.451 1.00 21.25 ? 55 SER A CB 1 ATOM 268 O OG . SER A 1 35 ? 45.826 -59.307 -22.261 1.00 19.56 ? 55 SER A OG 1 ATOM 269 N N . TYR A 1 36 ? 44.658 -55.618 -24.960 1.00 16.61 ? 56 TYR A N 1 ATOM 270 C CA . TYR A 1 36 ? 44.362 -54.191 -25.066 1.00 18.52 ? 56 TYR A CA 1 ATOM 271 C C . TYR A 1 36 ? 42.986 -53.713 -24.440 1.00 17.62 ? 56 TYR A C 1 ATOM 272 O O . TYR A 1 36 ? 42.952 -52.694 -23.751 1.00 15.99 ? 56 TYR A O 1 ATOM 273 C CB . TYR A 1 36 ? 44.524 -53.719 -26.514 1.00 18.74 ? 56 TYR A CB 1 ATOM 274 C CG . TYR A 1 36 ? 43.509 -54.250 -27.520 1.00 19.97 ? 56 TYR A CG 1 ATOM 275 C CD1 . TYR A 1 36 ? 43.579 -55.550 -28.010 1.00 21.01 ? 56 TYR A CD1 1 ATOM 276 C CD2 . TYR A 1 36 ? 42.468 -53.442 -27.966 1.00 20.89 ? 56 TYR A CD2 1 ATOM 277 C CE1 . TYR A 1 36 ? 42.640 -56.034 -28.951 1.00 22.73 ? 56 TYR A CE1 1 ATOM 278 C CE2 . TYR A 1 36 ? 41.497 -53.932 -28.880 1.00 22.16 ? 56 TYR A CE2 1 ATOM 279 C CZ . TYR A 1 36 ? 41.591 -55.205 -29.376 1.00 21.40 ? 56 TYR A CZ 1 ATOM 280 O OH . TYR A 1 36 ? 40.675 -55.665 -30.289 1.00 21.26 ? 56 TYR A OH 1 ATOM 281 N N . LEU A 1 37 ? 41.874 -54.415 -24.722 1.00 15.79 ? 57 LEU A N 1 ATOM 282 C CA . LEU A 1 37 ? 40.582 -54.021 -24.129 1.00 15.99 ? 57 LEU A CA 1 ATOM 283 C C . LEU A 1 37 ? 40.512 -54.422 -22.670 1.00 15.26 ? 57 LEU A C 1 ATOM 284 O O . LEU A 1 37 ? 40.017 -53.641 -21.832 1.00 16.07 ? 57 LEU A O 1 ATOM 285 C CB . LEU A 1 37 ? 39.351 -54.548 -24.873 1.00 15.61 ? 57 LEU A CB 1 ATOM 286 C CG . LEU A 1 37 ? 39.205 -54.093 -26.309 1.00 16.67 ? 57 LEU A CG 1 ATOM 287 C CD1 . LEU A 1 37 ? 37.929 -54.731 -26.865 1.00 18.34 ? 57 LEU A CD1 1 ATOM 288 C CD2 . LEU A 1 37 ? 39.124 -52.571 -26.528 1.00 16.78 ? 57 LEU A CD2 1 ATOM 289 N N . ALA A 1 38 ? 40.979 -55.622 -22.379 1.00 14.91 ? 58 ALA A N 1 ATOM 290 C CA . ALA A 1 38 ? 40.929 -56.142 -21.018 1.00 15.41 ? 58 ALA A CA 1 ATOM 291 C C . ALA A 1 38 ? 41.769 -55.331 -20.023 1.00 15.87 ? 58 ALA A C 1 ATOM 292 O O . ALA A 1 38 ? 41.357 -55.134 -18.864 1.00 15.22 ? 58 ALA A O 1 ATOM 293 C CB . ALA A 1 38 ? 41.345 -57.594 -20.983 1.00 15.14 ? 58 ALA A CB 1 ATOM 294 N N . ASN A 1 39 ? 42.852 -54.741 -20.510 1.00 15.41 ? 59 ASN A N 1 ATOM 295 C CA . ASN A 1 39 ? 43.739 -53.905 -19.699 1.00 14.87 ? 59 ASN A CA 1 ATOM 296 C C . ASN A 1 39 ? 43.109 -52.611 -19.200 1.00 15.57 ? 59 ASN A C 1 ATOM 297 O O . ASN A 1 39 ? 43.592 -52.041 -18.239 1.00 15.21 ? 59 ASN A O 1 ATOM 298 C CB . ASN A 1 39 ? 45.011 -53.561 -20.497 1.00 15.12 ? 59 ASN A CB 1 ATOM 299 C CG . ASN A 1 39 ? 45.953 -54.757 -20.653 1.00 15.94 ? 59 ASN A CG 1 ATOM 300 O OD1 . ASN A 1 39 ? 45.842 -55.763 -19.922 1.00 14.51 ? 59 ASN A OD1 1 ATOM 301 N ND2 . ASN A 1 39 ? 46.918 -54.630 -21.578 1.00 16.13 ? 59 ASN A ND2 1 ATOM 302 N N . VAL A 1 40 ? 42.075 -52.130 -19.905 1.00 14.13 ? 60 VAL A N 1 ATOM 303 C CA . VAL A 1 40 ? 41.445 -50.845 -19.619 1.00 13.92 ? 60 VAL A CA 1 ATOM 304 C C . VAL A 1 40 ? 39.984 -51.008 -19.155 1.00 13.05 ? 60 VAL A C 1 ATOM 305 O O . VAL A 1 40 ? 39.288 -50.010 -18.916 1.00 13.43 ? 60 VAL A O 1 ATOM 306 C CB . VAL A 1 40 ? 41.472 -49.849 -20.834 1.00 14.35 ? 60 VAL A CB 1 ATOM 307 C CG1 . VAL A 1 40 ? 42.881 -49.503 -21.254 1.00 15.15 ? 60 VAL A CG1 1 ATOM 308 C CG2 . VAL A 1 40 ? 40.636 -50.336 -22.017 1.00 13.94 ? 60 VAL A CG2 1 ATOM 309 N N . ALA A 1 41 ? 39.552 -52.249 -19.012 1.00 14.31 ? 61 ALA A N 1 ATOM 310 C CA . ALA A 1 41 ? 38.129 -52.565 -18.770 1.00 16.80 ? 61 ALA A CA 1 ATOM 311 C C . ALA A 1 41 ? 37.633 -52.138 -17.368 1.00 16.39 ? 61 ALA A C 1 ATOM 312 O O . ALA A 1 41 ? 36.406 -52.090 -17.152 1.00 17.11 ? 61 ALA A O 1 ATOM 313 C CB . ALA A 1 41 ? 37.862 -54.048 -18.977 1.00 16.17 ? 61 ALA A CB 1 ATOM 314 N N . THR A 1 42 ? 38.558 -51.911 -16.436 1.00 14.97 ? 62 THR A N 1 ATOM 315 C CA . THR A 1 42 ? 38.199 -51.455 -15.117 1.00 15.86 ? 62 THR A CA 1 ATOM 316 C C . THR A 1 42 ? 38.466 -49.977 -14.901 1.00 15.75 ? 62 THR A C 1 ATOM 317 O O . THR A 1 42 ? 38.118 -49.444 -13.842 1.00 15.34 ? 62 THR A O 1 ATOM 318 C CB . THR A 1 42 ? 38.888 -52.262 -14.000 1.00 17.33 ? 62 THR A CB 1 ATOM 319 O OG1 . THR A 1 42 ? 40.289 -51.927 -13.939 1.00 18.50 ? 62 THR A OG1 1 ATOM 320 C CG2 . THR A 1 42 ? 38.736 -53.740 -14.238 1.00 18.00 ? 62 THR A CG2 1 ATOM 321 N N . TRP A 1 43 ? 39.057 -49.306 -15.901 1.00 15.00 ? 63 TRP A N 1 ATOM 322 C CA . TRP A 1 43 ? 39.470 -47.948 -15.709 1.00 13.23 ? 63 TRP A CA 1 ATOM 323 C C . TRP A 1 43 ? 38.365 -47.038 -15.172 1.00 13.03 ? 63 TRP A C 1 ATOM 324 O O . TRP A 1 43 ? 38.597 -46.186 -14.349 1.00 12.09 ? 63 TRP A O 1 ATOM 325 C CB . TRP A 1 43 ? 40.042 -47.353 -16.999 1.00 13.30 ? 63 TRP A CB 1 ATOM 326 C CG . TRP A 1 43 ? 40.335 -45.866 -16.889 1.00 11.92 ? 63 TRP A CG 1 ATOM 327 C CD1 . TRP A 1 43 ? 41.476 -45.280 -16.319 1.00 13.33 ? 63 TRP A CD1 1 ATOM 328 C CD2 . TRP A 1 43 ? 39.480 -44.791 -17.270 1.00 12.23 ? 63 TRP A CD2 1 ATOM 329 N NE1 . TRP A 1 43 ? 41.378 -43.901 -16.378 1.00 13.76 ? 63 TRP A NE1 1 ATOM 330 C CE2 . TRP A 1 43 ? 40.162 -43.571 -16.958 1.00 12.18 ? 63 TRP A CE2 1 ATOM 331 C CE3 . TRP A 1 43 ? 38.157 -44.735 -17.806 1.00 11.92 ? 63 TRP A CE3 1 ATOM 332 C CZ2 . TRP A 1 43 ? 39.588 -42.335 -17.146 1.00 13.07 ? 63 TRP A CZ2 1 ATOM 333 C CZ3 . TRP A 1 43 ? 37.568 -43.464 -18.048 1.00 12.20 ? 63 TRP A CZ3 1 ATOM 334 C CH2 . TRP A 1 43 ? 38.293 -42.262 -17.722 1.00 13.08 ? 63 TRP A CH2 1 ATOM 335 N N . ALA A 1 44 ? 37.159 -47.176 -15.701 1.00 12.66 ? 64 ALA A N 1 ATOM 336 C CA . ALA A 1 44 ? 36.090 -46.257 -15.315 1.00 11.99 ? 64 ALA A CA 1 ATOM 337 C C . ALA A 1 44 ? 35.828 -46.322 -13.823 1.00 12.60 ? 64 ALA A C 1 ATOM 338 O O . ALA A 1 44 ? 35.500 -45.284 -13.208 1.00 13.37 ? 64 ALA A O 1 ATOM 339 C CB . ALA A 1 44 ? 34.847 -46.509 -16.103 1.00 12.11 ? 64 ALA A CB 1 ATOM 340 N N . ASN A 1 45 ? 35.984 -47.527 -13.250 1.00 12.24 ? 65 ASN A N 1 ATOM 341 C CA . ASN A 1 45 ? 35.898 -47.667 -11.827 1.00 13.20 ? 65 ASN A CA 1 ATOM 342 C C . ASN A 1 45 ? 37.011 -46.923 -11.125 1.00 12.64 ? 65 ASN A C 1 ATOM 343 O O . ASN A 1 45 ? 36.757 -46.155 -10.205 1.00 12.43 ? 65 ASN A O 1 ATOM 344 C CB . ASN A 1 45 ? 35.854 -49.131 -11.367 1.00 12.91 ? 65 ASN A CB 1 ATOM 345 C CG . ASN A 1 45 ? 34.482 -49.750 -11.554 1.00 12.70 ? 65 ASN A CG 1 ATOM 346 O OD1 . ASN A 1 45 ? 33.518 -49.063 -11.834 1.00 11.89 ? 65 ASN A OD1 1 ATOM 347 N ND2 . ASN A 1 45 ? 34.421 -51.040 -11.444 1.00 12.50 ? 65 ASN A ND2 1 ATOM 348 N N . THR A 1 46 ? 38.233 -47.142 -11.568 1.00 12.58 ? 66 THR A N 1 ATOM 349 C CA . THR A 1 46 ? 39.353 -46.393 -11.020 1.00 13.15 ? 66 THR A CA 1 ATOM 350 C C . THR A 1 46 ? 39.107 -44.898 -11.034 1.00 13.78 ? 66 THR A C 1 ATOM 351 O O . THR A 1 46 ? 39.341 -44.173 -10.019 1.00 14.90 ? 66 THR A O 1 ATOM 352 C CB . THR A 1 46 ? 40.627 -46.738 -11.848 1.00 12.88 ? 66 THR A CB 1 ATOM 353 O OG1 . THR A 1 46 ? 40.730 -48.151 -11.877 1.00 13.15 ? 66 THR A OG1 1 ATOM 354 C CG2 . THR A 1 46 ? 41.869 -46.160 -11.160 1.00 12.98 ? 66 THR A CG2 1 ATOM 355 N N . TYR A 1 47 ? 38.670 -44.419 -12.182 1.00 12.86 ? 67 TYR A N 1 ATOM 356 C CA . TYR A 1 47 ? 38.509 -42.994 -12.433 1.00 13.99 ? 67 TYR A CA 1 ATOM 357 C C . TYR A 1 47 ? 37.423 -42.324 -11.547 1.00 13.62 ? 67 TYR A C 1 ATOM 358 O O . TYR A 1 47 ? 37.595 -41.177 -11.096 1.00 13.01 ? 67 TYR A O 1 ATOM 359 C CB . TYR A 1 47 ? 38.164 -42.790 -13.898 1.00 14.47 ? 67 TYR A CB 1 ATOM 360 C CG . TYR A 1 47 ? 38.050 -41.372 -14.362 1.00 15.58 ? 67 TYR A CG 1 ATOM 361 C CD1 . TYR A 1 47 ? 39.147 -40.487 -14.324 1.00 15.78 ? 67 TYR A CD1 1 ATOM 362 C CD2 . TYR A 1 47 ? 36.844 -40.898 -14.869 1.00 16.56 ? 67 TYR A CD2 1 ATOM 363 C CE1 . TYR A 1 47 ? 39.045 -39.168 -14.771 1.00 15.67 ? 67 TYR A CE1 1 ATOM 364 C CE2 . TYR A 1 47 ? 36.751 -39.611 -15.363 1.00 16.86 ? 67 TYR A CE2 1 ATOM 365 C CZ . TYR A 1 47 ? 37.842 -38.742 -15.302 1.00 18.16 ? 67 TYR A CZ 1 ATOM 366 O OH . TYR A 1 47 ? 37.657 -37.456 -15.802 1.00 17.68 ? 67 TYR A OH 1 ATOM 367 N N . LYS A 1 48 ? 36.336 -43.051 -11.329 1.00 12.40 ? 68 LYS A N 1 ATOM 368 C CA . LYS A 1 48 ? 35.213 -42.492 -10.546 1.00 14.16 ? 68 LYS A CA 1 ATOM 369 C C . LYS A 1 48 ? 35.608 -42.154 -9.067 1.00 13.72 ? 68 LYS A C 1 ATOM 370 O O . LYS A 1 48 ? 34.928 -41.326 -8.432 1.00 13.50 ? 68 LYS A O 1 ATOM 371 C CB . LYS A 1 48 ? 33.979 -43.382 -10.591 1.00 13.37 ? 68 LYS A CB 1 ATOM 372 C CG . LYS A 1 48 ? 34.058 -44.588 -9.670 1.00 13.68 ? 68 LYS A CG 1 ATOM 373 C CD . LYS A 1 48 ? 32.915 -45.538 -10.025 1.00 13.94 ? 68 LYS A CD 1 ATOM 374 C CE . LYS A 1 48 ? 32.770 -46.783 -9.177 1.00 14.09 ? 68 LYS A CE 1 ATOM 375 N NZ . LYS A 1 48 ? 31.712 -47.707 -9.743 1.00 13.21 ? 68 LYS A NZ 1 ATOM 376 N N . TYR A 1 49 ? 36.689 -42.779 -8.575 1.00 14.53 ? 69 TYR A N 1 ATOM 377 C CA . TYR A 1 49 ? 37.212 -42.528 -7.238 1.00 15.04 ? 69 TYR A CA 1 ATOM 378 C C . TYR A 1 49 ? 38.314 -41.450 -7.127 1.00 15.74 ? 69 TYR A C 1 ATOM 379 O O . TYR A 1 49 ? 38.844 -41.208 -6.036 1.00 14.67 ? 69 TYR A O 1 ATOM 380 C CB . TYR A 1 49 ? 37.659 -43.826 -6.584 1.00 15.10 ? 69 TYR A CB 1 ATOM 381 C CG . TYR A 1 49 ? 36.585 -44.913 -6.539 1.00 15.83 ? 69 TYR A CG 1 ATOM 382 C CD1 . TYR A 1 49 ? 35.408 -44.706 -5.848 1.00 15.68 ? 69 TYR A CD1 1 ATOM 383 C CD2 . TYR A 1 49 ? 36.796 -46.170 -7.129 1.00 17.56 ? 69 TYR A CD2 1 ATOM 384 C CE1 . TYR A 1 49 ? 34.441 -45.693 -5.754 1.00 16.64 ? 69 TYR A CE1 1 ATOM 385 C CE2 . TYR A 1 49 ? 35.842 -47.187 -7.002 1.00 18.51 ? 69 TYR A CE2 1 ATOM 386 C CZ . TYR A 1 49 ? 34.657 -46.920 -6.317 1.00 18.54 ? 69 TYR A CZ 1 ATOM 387 O OH . TYR A 1 49 ? 33.689 -47.897 -6.223 1.00 20.24 ? 69 TYR A OH 1 ATOM 388 N N . THR A 1 50 ? 38.596 -40.800 -8.249 1.00 15.37 ? 70 THR A N 1 ATOM 389 C CA . THR A 1 50 ? 39.546 -39.709 -8.297 1.00 14.85 ? 70 THR A CA 1 ATOM 390 C C . THR A 1 50 ? 38.805 -38.360 -8.201 1.00 16.56 ? 70 THR A C 1 ATOM 391 O O . THR A 1 50 ? 37.615 -38.243 -8.512 1.00 15.04 ? 70 THR A O 1 ATOM 392 C CB . THR A 1 50 ? 40.351 -39.736 -9.619 1.00 15.31 ? 70 THR A CB 1 ATOM 393 O OG1 . THR A 1 50 ? 39.535 -39.337 -10.722 1.00 12.72 ? 70 THR A OG1 1 ATOM 394 C CG2 . THR A 1 50 ? 40.985 -41.074 -9.896 1.00 14.95 ? 70 THR A CG2 1 ATOM 395 N N . ASP A 1 51 ? 39.561 -37.318 -7.882 1.00 16.52 ? 71 ASP A N 1 ATOM 396 C CA . ASP A 1 51 ? 39.024 -35.989 -7.884 1.00 18.93 ? 71 ASP A CA 1 ATOM 397 C C . ASP A 1 51 ? 38.348 -35.598 -9.227 1.00 16.62 ? 71 ASP A C 1 ATOM 398 O O . ASP A 1 51 ? 37.231 -35.113 -9.266 1.00 16.18 ? 71 ASP A O 1 ATOM 399 C CB . ASP A 1 51 ? 40.112 -34.983 -7.504 1.00 21.46 ? 71 ASP A CB 1 ATOM 400 C CG . ASP A 1 51 ? 39.554 -33.611 -7.345 1.00 27.20 ? 71 ASP A CG 1 ATOM 401 O OD1 . ASP A 1 51 ? 39.465 -32.895 -8.349 1.00 30.51 ? 71 ASP A OD1 1 ATOM 402 O OD2 . ASP A 1 51 ? 39.177 -33.239 -6.210 1.00 33.84 ? 71 ASP A OD2 1 ATOM 403 N N . ALA A 1 52 ? 39.063 -35.775 -10.301 1.00 14.84 ? 72 ALA A N 1 ATOM 404 C CA . ALA A 1 52 ? 38.557 -35.379 -11.619 1.00 15.30 ? 72 ALA A CA 1 ATOM 405 C C . ALA A 1 52 ? 37.355 -36.215 -12.077 1.00 16.30 ? 72 ALA A C 1 ATOM 406 O O . ALA A 1 52 ? 36.514 -35.722 -12.838 1.00 17.17 ? 72 ALA A O 1 ATOM 407 C CB . ALA A 1 52 ? 39.669 -35.493 -12.659 1.00 15.16 ? 72 ALA A CB 1 ATOM 408 N N . GLY A 1 53 ? 37.291 -37.472 -11.638 1.00 16.03 ? 73 GLY A N 1 ATOM 409 C CA . GLY A 1 53 ? 36.292 -38.399 -12.150 1.00 16.87 ? 73 GLY A CA 1 ATOM 410 C C . GLY A 1 53 ? 35.069 -38.633 -11.269 1.00 17.78 ? 73 GLY A C 1 ATOM 411 O O . GLY A 1 53 ? 34.196 -39.406 -11.668 1.00 16.90 ? 73 GLY A O 1 ATOM 412 N N . GLU A 1 54 ? 35.021 -37.989 -10.082 1.00 17.58 ? 74 GLU A N 1 ATOM 413 C CA . GLU A 1 54 ? 33.902 -38.166 -9.144 1.00 19.36 ? 74 GLU A CA 1 ATOM 414 C C . GLU A 1 54 ? 32.514 -38.001 -9.816 1.00 17.63 ? 74 GLU A C 1 ATOM 415 O O . GLU A 1 54 ? 31.603 -38.779 -9.554 1.00 17.67 ? 74 GLU A O 1 ATOM 416 C CB . GLU A 1 54 ? 34.027 -37.159 -7.978 1.00 20.78 ? 74 GLU A CB 1 ATOM 417 C CG . GLU A 1 54 ? 33.152 -37.487 -6.816 1.00 26.14 ? 74 GLU A CG 1 ATOM 418 C CD . GLU A 1 54 ? 33.287 -36.496 -5.628 1.00 31.99 ? 74 GLU A CD 1 ATOM 419 O OE1 . GLU A 1 54 ? 32.759 -36.780 -4.544 1.00 30.86 ? 74 GLU A OE1 1 ATOM 420 O OE2 . GLU A 1 54 ? 33.920 -35.430 -5.760 1.00 33.75 ? 74 GLU A OE2 1 ATOM 421 N N . PHE A 1 55 ? 32.422 -37.007 -10.699 1.00 16.56 ? 75 PHE A N 1 ATOM 422 C CA . PHE A 1 55 ? 31.215 -36.693 -11.434 1.00 17.82 ? 75 PHE A CA 1 ATOM 423 C C . PHE A 1 55 ? 30.635 -37.915 -12.237 1.00 17.12 ? 75 PHE A C 1 ATOM 424 O O . PHE A 1 55 ? 29.450 -37.919 -12.571 1.00 16.65 ? 75 PHE A O 1 ATOM 425 C CB . PHE A 1 55 ? 31.449 -35.516 -12.421 1.00 17.85 ? 75 PHE A CB 1 ATOM 426 C CG . PHE A 1 55 ? 32.156 -35.940 -13.700 1.00 18.01 ? 75 PHE A CG 1 ATOM 427 C CD1 . PHE A 1 55 ? 33.514 -36.088 -13.736 1.00 18.65 ? 75 PHE A CD1 1 ATOM 428 C CD2 . PHE A 1 55 ? 31.431 -36.182 -14.853 1.00 18.30 ? 75 PHE A CD2 1 ATOM 429 C CE1 . PHE A 1 55 ? 34.155 -36.493 -14.892 1.00 19.17 ? 75 PHE A CE1 1 ATOM 430 C CE2 . PHE A 1 55 ? 32.042 -36.612 -16.001 1.00 18.60 ? 75 PHE A CE2 1 ATOM 431 C CZ . PHE A 1 55 ? 33.404 -36.794 -16.036 1.00 20.12 ? 75 PHE A CZ 1 ATOM 432 N N . SER A 1 56 ? 31.484 -38.885 -12.574 1.00 16.21 ? 76 SER A N 1 ATOM 433 C CA . SER A 1 56 ? 31.118 -39.996 -13.430 1.00 16.46 ? 76 SER A CA 1 ATOM 434 C C . SER A 1 56 ? 30.587 -41.233 -12.713 1.00 17.64 ? 76 SER A C 1 ATOM 435 O O . SER A 1 56 ? 30.183 -42.188 -13.404 1.00 15.07 ? 76 SER A O 1 ATOM 436 C CB . SER A 1 56 ? 32.311 -40.417 -14.341 1.00 16.93 ? 76 SER A CB 1 ATOM 437 O OG . SER A 1 56 ? 33.396 -40.976 -13.629 1.00 15.43 ? 76 SER A OG 1 ATOM 438 N N . LYS A 1 57 ? 30.562 -41.207 -11.360 1.00 15.67 ? 77 LYS A N 1 ATOM 439 C CA . LYS A 1 57 ? 29.989 -42.311 -10.608 1.00 16.04 ? 77 LYS A CA 1 ATOM 440 C C . LYS A 1 57 ? 28.588 -42.798 -11.069 1.00 14.38 ? 77 LYS A C 1 ATOM 441 O O . LYS A 1 57 ? 28.353 -43.977 -11.090 1.00 15.51 ? 77 LYS A O 1 ATOM 442 C CB . LYS A 1 57 ? 29.911 -41.994 -9.094 1.00 17.28 ? 77 LYS A CB 1 ATOM 443 C CG . LYS A 1 57 ? 31.238 -42.168 -8.361 1.00 19.27 ? 77 LYS A CG 1 ATOM 444 C CD . LYS A 1 57 ? 31.157 -41.702 -6.903 1.00 19.96 ? 77 LYS A CD 1 ATOM 445 C CE . LYS A 1 57 ? 32.544 -41.858 -6.288 1.00 19.93 ? 77 LYS A CE 1 ATOM 446 N NZ . LYS A 1 57 ? 32.545 -41.522 -4.842 1.00 19.85 ? 77 LYS A NZ 1 ATOM 447 N N . PRO A 1 58 ? 27.655 -41.889 -11.306 1.00 15.58 ? 78 PRO A N 1 ATOM 448 C CA . PRO A 1 58 ? 26.299 -42.290 -11.748 1.00 16.30 ? 78 PRO A CA 1 ATOM 449 C C . PRO A 1 58 ? 26.226 -42.951 -13.142 1.00 16.48 ? 78 PRO A C 1 ATOM 450 O O . PRO A 1 58 ? 25.207 -43.549 -13.480 1.00 13.62 ? 78 PRO A O 1 ATOM 451 C CB . PRO A 1 58 ? 25.538 -40.965 -11.789 1.00 17.07 ? 78 PRO A CB 1 ATOM 452 C CG . PRO A 1 58 ? 26.377 -39.970 -11.010 1.00 18.11 ? 78 PRO A CG 1 ATOM 453 C CD . PRO A 1 58 ? 27.775 -40.421 -11.217 1.00 16.68 ? 78 PRO A CD 1 ATOM 454 N N . TYR A 1 59 ? 27.323 -42.870 -13.900 1.00 15.49 ? 79 TYR A N 1 ATOM 455 C CA . TYR A 1 59 ? 27.368 -43.377 -15.277 1.00 15.85 ? 79 TYR A CA 1 ATOM 456 C C . TYR A 1 59 ? 27.470 -44.893 -15.336 1.00 14.65 ? 79 TYR A C 1 ATOM 457 O O . TYR A 1 59 ? 27.434 -45.465 -16.388 1.00 16.07 ? 79 TYR A O 1 ATOM 458 C CB . TYR A 1 59 ? 28.534 -42.743 -16.066 1.00 15.19 ? 79 TYR A CB 1 ATOM 459 C CG . TYR A 1 59 ? 28.560 -41.231 -16.231 1.00 15.35 ? 79 TYR A CG 1 ATOM 460 C CD1 . TYR A 1 59 ? 27.501 -40.413 -15.844 1.00 17.02 ? 79 TYR A CD1 1 ATOM 461 C CD2 . TYR A 1 59 ? 29.650 -40.632 -16.843 1.00 15.38 ? 79 TYR A CD2 1 ATOM 462 C CE1 . TYR A 1 59 ? 27.530 -39.032 -16.050 1.00 17.68 ? 79 TYR A CE1 1 ATOM 463 C CE2 . TYR A 1 59 ? 29.699 -39.278 -17.072 1.00 16.66 ? 79 TYR A CE2 1 ATOM 464 C CZ . TYR A 1 59 ? 28.651 -38.466 -16.676 1.00 17.75 ? 79 TYR A CZ 1 ATOM 465 O OH . TYR A 1 59 ? 28.750 -37.117 -16.919 1.00 16.39 ? 79 TYR A OH 1 ATOM 466 N N . HIS A 1 60 ? 27.586 -45.539 -14.190 1.00 13.78 ? 80 HIS A N 1 ATOM 467 C CA . HIS A 1 60 ? 27.754 -46.977 -14.138 1.00 13.94 ? 80 HIS A CA 1 ATOM 468 C C . HIS A 1 60 ? 26.466 -47.785 -14.055 1.00 12.96 ? 80 HIS A C 1 ATOM 469 O O . HIS A 1 60 ? 26.502 -49.056 -14.130 1.00 13.81 ? 80 HIS A O 1 ATOM 470 C CB . HIS A 1 60 ? 28.661 -47.328 -12.930 1.00 13.02 ? 80 HIS A CB 1 ATOM 471 C CG . HIS A 1 60 ? 30.049 -46.827 -13.116 1.00 14.84 ? 80 HIS A CG 1 ATOM 472 N ND1 . HIS A 1 60 ? 31.129 -47.685 -13.273 1.00 14.51 ? 80 HIS A ND1 1 ATOM 473 C CD2 . HIS A 1 60 ? 30.513 -45.566 -13.347 1.00 14.28 ? 80 HIS A CD2 1 ATOM 474 C CE1 . HIS A 1 60 ? 32.211 -46.955 -13.504 1.00 15.78 ? 80 HIS A CE1 1 ATOM 475 N NE2 . HIS A 1 60 ? 31.856 -45.678 -13.597 1.00 15.12 ? 80 HIS A NE2 1 ATOM 476 N N . PHE A 1 61 ? 25.344 -47.075 -13.913 1.00 14.01 ? 81 PHE A N 1 ATOM 477 C CA . PHE A 1 61 ? 24.052 -47.755 -13.679 1.00 14.05 ? 81 PHE A CA 1 ATOM 478 C C . PHE A 1 61 ? 22.896 -46.899 -14.137 1.00 14.13 ? 81 PHE A C 1 ATOM 479 O O . PHE A 1 61 ? 23.033 -45.719 -14.513 1.00 13.99 ? 81 PHE A O 1 ATOM 480 C CB . PHE A 1 61 ? 23.929 -48.193 -12.190 1.00 13.66 ? 81 PHE A CB 1 ATOM 481 C CG . PHE A 1 61 ? 24.119 -47.053 -11.242 1.00 14.84 ? 81 PHE A CG 1 ATOM 482 C CD1 . PHE A 1 61 ? 23.059 -46.186 -10.943 1.00 14.49 ? 81 PHE A CD1 1 ATOM 483 C CD2 . PHE A 1 61 ? 25.374 -46.830 -10.649 1.00 15.15 ? 81 PHE A CD2 1 ATOM 484 C CE1 . PHE A 1 61 ? 23.242 -45.130 -10.087 1.00 16.25 ? 81 PHE A CE1 1 ATOM 485 C CE2 . PHE A 1 61 ? 25.569 -45.772 -9.785 1.00 15.85 ? 81 PHE A CE2 1 ATOM 486 C CZ . PHE A 1 61 ? 24.520 -44.911 -9.500 1.00 16.85 ? 81 PHE A CZ 1 ATOM 487 N N . ILE A 1 62 ? 21.729 -47.516 -14.188 1.00 14.89 ? 82 ILE A N 1 ATOM 488 C CA . ILE A 1 62 ? 20.467 -46.737 -14.359 1.00 15.71 ? 82 ILE A CA 1 ATOM 489 C C . ILE A 1 62 ? 19.502 -47.290 -13.301 1.00 15.52 ? 82 ILE A C 1 ATOM 490 O O . ILE A 1 62 ? 19.222 -48.475 -13.251 1.00 13.61 ? 82 ILE A O 1 ATOM 491 C CB . ILE A 1 62 ? 19.901 -46.764 -15.808 1.00 16.43 ? 82 ILE A CB 1 ATOM 492 C CG1 . ILE A 1 62 ? 18.606 -45.920 -15.879 1.00 16.35 ? 82 ILE A CG1 1 ATOM 493 C CG2 . ILE A 1 62 ? 19.716 -48.215 -16.304 1.00 16.71 ? 82 ILE A CG2 1 ATOM 494 C CD1 . ILE A 1 62 ? 18.090 -45.600 -17.272 1.00 18.02 ? 82 ILE A CD1 1 ATOM 495 N N . ASP A 1 63 ? 19.078 -46.411 -12.424 1.00 16.61 ? 83 ASP A N 1 ATOM 496 C CA . ASP A 1 63 ? 18.283 -46.823 -11.256 1.00 16.08 ? 83 ASP A CA 1 ATOM 497 C C . ASP A 1 63 ? 16.784 -46.992 -11.610 1.00 15.90 ? 83 ASP A C 1 ATOM 498 O O . ASP A 1 63 ? 15.921 -46.111 -11.307 1.00 17.52 ? 83 ASP A O 1 ATOM 499 C CB . ASP A 1 63 ? 18.464 -45.822 -10.131 1.00 15.33 ? 83 ASP A CB 1 ATOM 500 C CG . ASP A 1 63 ? 19.697 -46.096 -9.268 1.00 16.99 ? 83 ASP A CG 1 ATOM 501 O OD1 . ASP A 1 63 ? 20.179 -47.232 -9.184 1.00 17.48 ? 83 ASP A OD1 1 ATOM 502 O OD2 . ASP A 1 63 ? 20.170 -45.128 -8.618 1.00 19.25 ? 83 ASP A OD2 1 ATOM 503 N N . ALA A 1 64 ? 16.487 -48.115 -12.231 1.00 14.72 ? 84 ALA A N 1 ATOM 504 C CA . ALA A 1 64 ? 15.144 -48.379 -12.714 1.00 16.18 ? 84 ALA A CA 1 ATOM 505 C C . ALA A 1 64 ? 14.134 -48.412 -11.538 1.00 17.61 ? 84 ALA A C 1 ATOM 506 O O . ALA A 1 64 ? 14.282 -49.227 -10.605 1.00 18.03 ? 84 ALA A O 1 ATOM 507 C CB . ALA A 1 64 ? 15.080 -49.676 -13.467 1.00 16.12 ? 84 ALA A CB 1 ATOM 508 N N . GLN A 1 65 ? 13.133 -47.538 -11.614 1.00 19.87 ? 85 GLN A N 1 ATOM 509 C CA . GLN A 1 65 ? 12.097 -47.402 -10.532 1.00 21.01 ? 85 GLN A CA 1 ATOM 510 C C . GLN A 1 65 ? 10.892 -48.312 -10.806 1.00 20.01 ? 85 GLN A C 1 ATOM 511 O O . GLN A 1 65 ? 9.812 -47.849 -11.071 1.00 20.34 ? 85 GLN A O 1 ATOM 512 C CB . GLN A 1 65 ? 11.688 -45.962 -10.420 1.00 23.11 ? 85 GLN A CB 1 ATOM 513 C CG . GLN A 1 65 ? 12.858 -45.094 -9.994 1.00 26.48 ? 85 GLN A CG 1 ATOM 514 C CD . GLN A 1 65 ? 12.464 -43.645 -9.840 1.00 33.23 ? 85 GLN A CD 1 ATOM 515 O OE1 . GLN A 1 65 ? 11.544 -43.337 -9.131 1.00 38.75 ? 85 GLN A OE1 1 ATOM 516 N NE2 . GLN A 1 65 ? 13.141 -42.757 -10.516 1.00 36.64 ? 85 GLN A NE2 1 ATOM 517 N N . ASP A 1 66 ? 11.150 -49.607 -10.803 1.00 18.57 ? 86 ASP A N 1 ATOM 518 C CA . ASP A 1 66 ? 10.175 -50.598 -11.157 1.00 18.55 ? 86 ASP A CA 1 ATOM 519 C C . ASP A 1 66 ? 9.721 -51.282 -9.862 1.00 17.41 ? 86 ASP A C 1 ATOM 520 O O . ASP A 1 66 ? 9.906 -50.748 -8.807 1.00 19.71 ? 86 ASP A O 1 ATOM 521 C CB . ASP A 1 66 ? 10.706 -51.541 -12.240 1.00 18.67 ? 86 ASP A CB 1 ATOM 522 C CG . ASP A 1 66 ? 12.049 -52.220 -11.879 1.00 18.72 ? 86 ASP A CG 1 ATOM 523 O OD1 . ASP A 1 66 ? 12.594 -52.029 -10.731 1.00 17.71 ? 86 ASP A OD1 1 ATOM 524 O OD2 . ASP A 1 66 ? 12.498 -53.006 -12.756 1.00 18.88 ? 86 ASP A OD2 1 ATOM 525 N N . ASN A 1 67 ? 9.149 -52.451 -9.954 1.00 18.98 ? 87 ASN A N 1 ATOM 526 C CA . ASN A 1 67 ? 8.480 -53.089 -8.833 1.00 20.68 ? 87 ASN A CA 1 ATOM 527 C C . ASN A 1 67 ? 8.862 -54.570 -8.707 1.00 18.90 ? 87 ASN A C 1 ATOM 528 O O . ASN A 1 67 ? 7.998 -55.432 -8.741 1.00 16.43 ? 87 ASN A O 1 ATOM 529 C CB . ASN A 1 67 ? 6.954 -52.891 -9.084 1.00 20.69 ? 87 ASN A CB 1 ATOM 530 C CG . ASN A 1 67 ? 6.080 -53.457 -7.967 1.00 21.83 ? 87 ASN A CG 1 ATOM 531 O OD1 . ASN A 1 67 ? 6.451 -53.398 -6.812 1.00 21.51 ? 87 ASN A OD1 1 ATOM 532 N ND2 . ASN A 1 67 ? 4.900 -54.021 -8.325 1.00 19.82 ? 87 ASN A ND2 1 ATOM 533 N N . PRO A 1 68 ? 10.197 -54.876 -8.610 1.00 19.13 ? 88 PRO A N 1 ATOM 534 C CA . PRO A 1 68 ? 10.605 -56.286 -8.558 1.00 17.62 ? 88 PRO A CA 1 ATOM 535 C C . PRO A 1 68 ? 10.274 -56.922 -7.237 1.00 16.26 ? 88 PRO A C 1 ATOM 536 O O . PRO A 1 68 ? 10.233 -56.234 -6.228 1.00 16.58 ? 88 PRO A O 1 ATOM 537 C CB . PRO A 1 68 ? 12.132 -56.206 -8.714 1.00 19.34 ? 88 PRO A CB 1 ATOM 538 C CG . PRO A 1 68 ? 12.466 -54.930 -8.005 1.00 19.19 ? 88 PRO A CG 1 ATOM 539 C CD . PRO A 1 68 ? 11.337 -53.991 -8.303 1.00 19.49 ? 88 PRO A CD 1 ATOM 540 N N . PRO A 1 69 ? 10.122 -58.227 -7.197 1.00 16.06 ? 89 PRO A N 1 ATOM 541 C CA . PRO A 1 69 ? 10.282 -59.121 -8.312 1.00 16.85 ? 89 PRO A CA 1 ATOM 542 C C . PRO A 1 69 ? 8.983 -59.350 -9.091 1.00 17.23 ? 89 PRO A C 1 ATOM 543 O O . PRO A 1 69 ? 8.992 -60.175 -10.026 1.00 17.69 ? 89 PRO A O 1 ATOM 544 C CB . PRO A 1 69 ? 10.700 -60.425 -7.647 1.00 17.61 ? 89 PRO A CB 1 ATOM 545 C CG . PRO A 1 69 ? 10.026 -60.363 -6.287 1.00 17.61 ? 89 PRO A CG 1 ATOM 546 C CD . PRO A 1 69 ? 10.104 -58.922 -5.902 1.00 17.42 ? 89 PRO A CD 1 ATOM 547 N N . GLN A 1 70 ? 7.917 -58.623 -8.772 1.00 17.11 ? 90 GLN A N 1 ATOM 548 C CA . GLN A 1 70 ? 6.648 -58.867 -9.537 1.00 20.71 ? 90 GLN A CA 1 ATOM 549 C C . GLN A 1 70 ? 6.630 -58.245 -10.945 1.00 19.42 ? 90 GLN A C 1 ATOM 550 O O . GLN A 1 70 ? 6.089 -58.830 -11.861 1.00 17.62 ? 90 GLN A O 1 ATOM 551 C CB . GLN A 1 70 ? 5.329 -58.588 -8.784 1.00 22.66 ? 90 GLN A CB 1 ATOM 552 C CG . GLN A 1 70 ? 5.301 -57.457 -7.837 1.00 23.41 ? 90 GLN A CG 1 ATOM 553 C CD . GLN A 1 70 ? 6.052 -57.709 -6.530 1.00 21.88 ? 90 GLN A CD 1 ATOM 554 O OE1 . GLN A 1 70 ? 6.203 -58.839 -6.004 1.00 25.16 ? 90 GLN A OE1 1 ATOM 555 N NE2 . GLN A 1 70 ? 6.556 -56.635 -6.018 1.00 22.45 ? 90 GLN A NE2 1 ATOM 556 N N . SER A 1 71 ? 7.232 -57.062 -11.086 1.00 21.33 ? 91 SER A N 1 ATOM 557 C CA . SER A 1 71 ? 7.353 -56.465 -12.389 1.00 21.95 ? 91 SER A CA 1 ATOM 558 C C . SER A 1 71 ? 8.607 -55.569 -12.520 1.00 20.47 ? 91 SER A C 1 ATOM 559 O O . SER A 1 71 ? 9.017 -54.813 -11.612 1.00 21.49 ? 91 SER A O 1 ATOM 560 C CB . SER A 1 71 ? 6.010 -55.835 -12.885 1.00 24.95 ? 91 SER A CB 1 ATOM 561 O OG . SER A 1 71 ? 5.878 -54.523 -12.569 1.00 26.89 ? 91 SER A OG 1 ATOM 562 N N . CYS A 1 72 ? 9.222 -55.735 -13.683 1.00 18.39 ? 92 CYS A N 1 ATOM 563 C CA . CYS A 1 72 ? 10.458 -55.089 -14.021 1.00 20.57 ? 92 CYS A CA 1 ATOM 564 C C . CYS A 1 72 ? 10.295 -54.219 -15.290 1.00 19.56 ? 92 CYS A C 1 ATOM 565 O O . CYS A 1 72 ? 9.548 -54.521 -16.174 1.00 21.67 ? 92 CYS A O 1 ATOM 566 C CB . CYS A 1 72 ? 11.533 -56.149 -14.221 1.00 20.02 ? 92 CYS A CB 1 ATOM 567 S SG . CYS A 1 72 ? 12.175 -56.709 -12.616 1.00 25.87 ? 92 CYS A SG 1 ATOM 568 N N . GLY A 1 73 ? 11.036 -53.144 -15.329 1.00 19.20 ? 93 GLY A N 1 ATOM 569 C CA . GLY A 1 73 ? 11.046 -52.272 -16.494 1.00 18.87 ? 93 GLY A CA 1 ATOM 570 C C . GLY A 1 73 ? 11.989 -51.107 -16.272 1.00 18.68 ? 93 GLY A C 1 ATOM 571 O O . GLY A 1 73 ? 12.132 -50.609 -15.160 1.00 19.32 ? 93 GLY A O 1 ATOM 572 N N . VAL A 1 74 ? 12.562 -50.629 -17.375 1.00 18.02 ? 94 VAL A N 1 ATOM 573 C CA . VAL A 1 74 ? 13.415 -49.491 -17.374 1.00 16.77 ? 94 VAL A CA 1 ATOM 574 C C . VAL A 1 74 ? 12.805 -48.438 -18.288 1.00 16.04 ? 94 VAL A C 1 ATOM 575 O O . VAL A 1 74 ? 12.363 -48.747 -19.363 1.00 16.80 ? 94 VAL A O 1 ATOM 576 C CB . VAL A 1 74 ? 14.811 -49.861 -17.914 1.00 16.95 ? 94 VAL A CB 1 ATOM 577 C CG1 . VAL A 1 74 ? 15.757 -48.681 -17.757 1.00 18.48 ? 94 VAL A CG1 1 ATOM 578 C CG2 . VAL A 1 74 ? 15.322 -51.077 -17.223 1.00 17.51 ? 94 VAL A CG2 1 ATOM 579 N N . ASP A 1 75 ? 12.848 -47.197 -17.854 1.00 16.71 ? 95 ASP A N 1 ATOM 580 C CA A ASP A 1 75 ? 12.263 -46.077 -18.581 0.50 17.82 ? 95 ASP A CA 1 ATOM 581 C CA B ASP A 1 75 ? 12.319 -46.102 -18.621 0.50 17.43 ? 95 ASP A CA 1 ATOM 582 C C . ASP A 1 75 ? 13.275 -44.952 -18.510 1.00 18.18 ? 95 ASP A C 1 ATOM 583 O O . ASP A 1 75 ? 13.496 -44.389 -17.416 1.00 20.32 ? 95 ASP A O 1 ATOM 584 C CB A ASP A 1 75 ? 10.943 -45.729 -17.875 0.50 18.86 ? 95 ASP A CB 1 ATOM 585 C CB B ASP A 1 75 ? 10.949 -45.669 -18.140 0.50 17.89 ? 95 ASP A CB 1 ATOM 586 C CG A ASP A 1 75 ? 10.224 -44.469 -18.414 0.50 20.40 ? 95 ASP A CG 1 ATOM 587 C CG B ASP A 1 75 ? 10.363 -44.547 -19.052 0.50 18.94 ? 95 ASP A CG 1 ATOM 588 O OD1 A ASP A 1 75 ? 10.836 -43.553 -19.003 0.50 22.37 ? 95 ASP A OD1 1 ATOM 589 O OD1 B ASP A 1 75 ? 10.851 -43.382 -18.987 0.50 20.24 ? 95 ASP A OD1 1 ATOM 590 O OD2 A ASP A 1 75 ? 8.994 -44.382 -18.187 0.50 20.63 ? 95 ASP A OD2 1 ATOM 591 O OD2 B ASP A 1 75 ? 9.480 -44.830 -19.886 0.50 18.27 ? 95 ASP A OD2 1 ATOM 592 N N . TYR A 1 76 ? 13.809 -44.571 -19.663 1.00 18.52 ? 96 TYR A N 1 ATOM 593 C CA . TYR A 1 76 ? 14.969 -43.663 -19.687 1.00 18.85 ? 96 TYR A CA 1 ATOM 594 C C . TYR A 1 76 ? 14.669 -42.313 -19.052 1.00 19.78 ? 96 TYR A C 1 ATOM 595 O O . TYR A 1 76 ? 15.425 -41.860 -18.161 1.00 17.40 ? 96 TYR A O 1 ATOM 596 C CB . TYR A 1 76 ? 15.477 -43.541 -21.117 1.00 18.23 ? 96 TYR A CB 1 ATOM 597 C CG . TYR A 1 76 ? 16.637 -42.606 -21.314 1.00 19.23 ? 96 TYR A CG 1 ATOM 598 C CD1 . TYR A 1 76 ? 17.844 -42.827 -20.666 1.00 19.26 ? 96 TYR A CD1 1 ATOM 599 C CD2 . TYR A 1 76 ? 16.512 -41.465 -22.149 1.00 20.59 ? 96 TYR A CD2 1 ATOM 600 C CE1 . TYR A 1 76 ? 18.891 -41.927 -20.806 1.00 20.29 ? 96 TYR A CE1 1 ATOM 601 C CE2 . TYR A 1 76 ? 17.563 -40.573 -22.324 1.00 20.16 ? 96 TYR A CE2 1 ATOM 602 C CZ . TYR A 1 76 ? 18.756 -40.814 -21.658 1.00 21.36 ? 96 TYR A CZ 1 ATOM 603 O OH . TYR A 1 76 ? 19.813 -39.978 -21.858 1.00 20.23 ? 96 TYR A OH 1 ATOM 604 N N . ASP A 1 77 ? 13.560 -41.702 -19.444 1.00 20.77 ? 97 ASP A N 1 ATOM 605 C CA . ASP A 1 77 ? 13.202 -40.374 -18.893 1.00 23.85 ? 97 ASP A CA 1 ATOM 606 C C . ASP A 1 77 ? 12.897 -40.422 -17.423 1.00 21.70 ? 97 ASP A C 1 ATOM 607 O O . ASP A 1 77 ? 13.252 -39.496 -16.689 1.00 21.01 ? 97 ASP A O 1 ATOM 608 C CB . ASP A 1 77 ? 12.064 -39.696 -19.657 1.00 28.41 ? 97 ASP A CB 1 ATOM 609 C CG . ASP A 1 77 ? 12.473 -39.363 -21.086 1.00 34.70 ? 97 ASP A CG 1 ATOM 610 O OD1 . ASP A 1 77 ? 13.651 -39.004 -21.364 1.00 37.58 ? 97 ASP A OD1 1 ATOM 611 O OD2 . ASP A 1 77 ? 11.633 -39.552 -21.948 1.00 41.08 ? 97 ASP A OD2 1 ATOM 612 N N . ARG A 1 78 ? 12.284 -41.516 -16.985 1.00 19.87 ? 98 ARG A N 1 ATOM 613 C CA . ARG A 1 78 ? 11.930 -41.681 -15.596 1.00 20.43 ? 98 ARG A CA 1 ATOM 614 C C . ARG A 1 78 ? 13.149 -41.976 -14.719 1.00 19.46 ? 98 ARG A C 1 ATOM 615 O O . ARG A 1 78 ? 13.235 -41.493 -13.613 1.00 18.41 ? 98 ARG A O 1 ATOM 616 C CB . ARG A 1 78 ? 10.932 -42.826 -15.467 1.00 20.94 ? 98 ARG A CB 1 ATOM 617 C CG . ARG A 1 78 ? 10.396 -42.999 -14.041 1.00 20.54 ? 98 ARG A CG 1 ATOM 618 C CD . ARG A 1 78 ? 9.590 -44.266 -13.948 1.00 22.63 ? 98 ARG A CD 1 ATOM 619 N NE . ARG A 1 78 ? 10.435 -45.440 -14.130 1.00 21.86 ? 98 ARG A NE 1 ATOM 620 C CZ . ARG A 1 78 ? 10.013 -46.671 -14.384 1.00 23.35 ? 98 ARG A CZ 1 ATOM 621 N NH1 . ARG A 1 78 ? 8.732 -46.930 -14.471 1.00 23.75 ? 98 ARG A NH1 1 ATOM 622 N NH2 . ARG A 1 78 ? 10.878 -47.672 -14.574 1.00 21.83 ? 98 ARG A NH2 1 ATOM 623 N N . ASP A 1 79 ? 14.093 -42.751 -15.266 1.00 19.23 ? 99 ASP A N 1 ATOM 624 C CA . ASP A 1 79 ? 15.118 -43.406 -14.439 1.00 18.34 ? 99 ASP A CA 1 ATOM 625 C C . ASP A 1 79 ? 16.533 -42.886 -14.470 1.00 19.59 ? 99 ASP A C 1 ATOM 626 O O . ASP A 1 79 ? 17.292 -43.152 -13.541 1.00 18.47 ? 99 ASP A O 1 ATOM 627 C CB . ASP A 1 79 ? 15.147 -44.891 -14.751 1.00 17.92 ? 99 ASP A CB 1 ATOM 628 C CG . ASP A 1 79 ? 13.830 -45.589 -14.432 1.00 18.20 ? 99 ASP A CG 1 ATOM 629 O OD1 . ASP A 1 79 ? 13.157 -45.133 -13.477 1.00 19.43 ? 99 ASP A OD1 1 ATOM 630 O OD2 . ASP A 1 79 ? 13.487 -46.580 -15.098 1.00 15.04 ? 99 ASP A OD2 1 ATOM 631 N N . CYS A 1 80 ? 16.904 -42.192 -15.548 1.00 20.39 ? 100 CYS A N 1 ATOM 632 C CA A CYS A 1 80 ? 18.290 -41.784 -15.724 0.50 20.13 ? 100 CYS A CA 1 ATOM 633 C CA B CYS A 1 80 ? 18.300 -41.763 -15.733 0.50 21.29 ? 100 CYS A CA 1 ATOM 634 C C . CYS A 1 80 ? 18.701 -40.791 -14.654 1.00 20.17 ? 100 CYS A C 1 ATOM 635 O O . CYS A 1 80 ? 19.652 -41.025 -13.919 1.00 21.87 ? 100 CYS A O 1 ATOM 636 C CB A CYS A 1 80 ? 18.516 -41.214 -17.132 0.50 19.31 ? 100 CYS A CB 1 ATOM 637 C CB B CYS A 1 80 ? 18.520 -41.114 -17.126 0.50 21.78 ? 100 CYS A CB 1 ATOM 638 S SG A CYS A 1 80 ? 20.264 -41.076 -17.569 0.50 18.36 ? 100 CYS A SG 1 ATOM 639 S SG B CYS A 1 80 ? 20.177 -40.390 -17.456 0.50 23.58 ? 100 CYS A SG 1 ATOM 640 N N . GLY A 1 81 ? 17.956 -39.697 -14.567 1.00 23.47 ? 101 GLY A N 1 ATOM 641 C CA . GLY A 1 81 ? 18.144 -38.636 -13.558 1.00 22.19 ? 101 GLY A CA 1 ATOM 642 C C . GLY A 1 81 ? 19.006 -37.516 -14.107 1.00 21.95 ? 101 GLY A C 1 ATOM 643 O O . GLY A 1 81 ? 19.668 -37.655 -15.104 1.00 21.69 ? 101 GLY A O 1 ATOM 644 N N . SER A 1 82 ? 19.040 -36.404 -13.408 1.00 25.14 ? 102 SER A N 1 ATOM 645 C CA . SER A 1 82 ? 19.770 -35.226 -13.914 1.00 27.03 ? 102 SER A CA 1 ATOM 646 C C . SER A 1 82 ? 21.321 -35.359 -13.776 1.00 25.29 ? 102 SER A C 1 ATOM 647 O O . SER A 1 82 ? 22.035 -34.679 -14.453 1.00 31.26 ? 102 SER A O 1 ATOM 648 C CB . SER A 1 82 ? 19.315 -33.989 -13.168 1.00 29.51 ? 102 SER A CB 1 ATOM 649 O OG . SER A 1 82 ? 19.607 -34.201 -11.799 1.00 33.05 ? 102 SER A OG 1 ATOM 650 N N . ALA A 1 83 ? 21.813 -36.302 -12.994 1.00 23.30 ? 103 ALA A N 1 ATOM 651 C CA . ALA A 1 83 ? 23.273 -36.548 -12.925 1.00 22.71 ? 103 ALA A CA 1 ATOM 652 C C . ALA A 1 83 ? 23.825 -37.480 -14.031 1.00 20.01 ? 103 ALA A C 1 ATOM 653 O O . ALA A 1 83 ? 25.029 -37.717 -14.106 1.00 21.19 ? 103 ALA A O 1 ATOM 654 C CB . ALA A 1 83 ? 23.644 -37.087 -11.555 1.00 21.52 ? 103 ALA A CB 1 ATOM 655 N N . GLY A 1 84 ? 22.953 -37.995 -14.877 1.00 18.46 ? 104 GLY A N 1 ATOM 656 C CA . GLY A 1 84 ? 23.321 -38.948 -15.904 1.00 16.77 ? 104 GLY A CA 1 ATOM 657 C C . GLY A 1 84 ? 23.260 -40.404 -15.380 1.00 17.98 ? 104 GLY A C 1 ATOM 658 O O . GLY A 1 84 ? 23.033 -40.678 -14.191 1.00 15.21 ? 104 GLY A O 1 ATOM 659 N N . CYS A 1 85 ? 23.439 -41.316 -16.316 1.00 16.52 ? 105 CYS A N 1 ATOM 660 C CA . CYS A 1 85 ? 23.323 -42.721 -16.043 1.00 16.54 ? 105 CYS A CA 1 ATOM 661 C C . CYS A 1 85 ? 24.097 -43.498 -17.136 1.00 15.44 ? 105 CYS A C 1 ATOM 662 O O . CYS A 1 85 ? 24.653 -42.888 -18.049 1.00 14.97 ? 105 CYS A O 1 ATOM 663 C CB . CYS A 1 85 ? 21.843 -43.093 -16.009 1.00 18.48 ? 105 CYS A CB 1 ATOM 664 S SG . CYS A 1 85 ? 21.009 -42.939 -17.613 1.00 17.96 ? 105 CYS A SG 1 ATOM 665 N N . SER A 1 86 ? 24.114 -44.810 -17.022 1.00 14.71 ? 106 SER A N 1 ATOM 666 C CA . SER A 1 86 ? 24.767 -45.700 -18.001 1.00 16.56 ? 106 SER A CA 1 ATOM 667 C C . SER A 1 86 ? 24.357 -45.419 -19.452 1.00 16.86 ? 106 SER A C 1 ATOM 668 O O . SER A 1 86 ? 25.187 -45.264 -20.312 1.00 14.84 ? 106 SER A O 1 ATOM 669 C CB . SER A 1 86 ? 24.516 -47.138 -17.662 1.00 16.49 ? 106 SER A CB 1 ATOM 670 O OG . SER A 1 86 ? 23.139 -47.380 -17.494 1.00 15.25 ? 106 SER A OG 1 ATOM 671 N N . ILE A 1 87 ? 23.074 -45.146 -19.631 1.00 15.69 ? 107 ILE A N 1 ATOM 672 C CA . ILE A 1 87 ? 22.495 -44.917 -20.923 1.00 15.12 ? 107 ILE A CA 1 ATOM 673 C C . ILE A 1 87 ? 22.892 -43.551 -21.476 1.00 14.72 ? 107 ILE A C 1 ATOM 674 O O . ILE A 1 87 ? 23.294 -43.482 -22.636 1.00 14.29 ? 107 ILE A O 1 ATOM 675 C CB . ILE A 1 87 ? 20.930 -44.999 -20.905 1.00 16.40 ? 107 ILE A CB 1 ATOM 676 C CG1 . ILE A 1 87 ? 20.466 -46.344 -20.340 1.00 16.33 ? 107 ILE A CG1 1 ATOM 677 C CG2 . ILE A 1 87 ? 20.332 -44.787 -22.292 1.00 16.68 ? 107 ILE A CG2 1 ATOM 678 C CD1 . ILE A 1 87 ? 21.029 -47.618 -20.992 1.00 16.93 ? 107 ILE A CD1 1 ATOM 679 N N . SER A 1 88 ? 22.800 -42.491 -20.676 1.00 15.33 ? 108 SER A N 1 ATOM 680 C CA . SER A 1 88 ? 23.214 -41.170 -21.140 1.00 16.20 ? 108 SER A CA 1 ATOM 681 C C . SER A 1 88 ? 24.748 -41.124 -21.418 1.00 16.95 ? 108 SER A C 1 ATOM 682 O O . SER A 1 88 ? 25.201 -40.405 -22.316 1.00 17.61 ? 108 SER A O 1 ATOM 683 C CB . SER A 1 88 ? 22.804 -40.057 -20.157 1.00 17.39 ? 108 SER A CB 1 ATOM 684 O OG . SER A 1 88 ? 23.551 -40.083 -18.950 1.00 17.35 ? 108 SER A OG 1 ATOM 685 N N . ALA A 1 89 ? 25.516 -41.875 -20.642 1.00 15.32 ? 109 ALA A N 1 ATOM 686 C CA . ALA A 1 89 ? 26.963 -41.951 -20.810 1.00 16.41 ? 109 ALA A CA 1 ATOM 687 C C . ALA A 1 89 ? 27.350 -42.709 -22.086 1.00 16.29 ? 109 ALA A C 1 ATOM 688 O O . ALA A 1 89 ? 28.216 -42.277 -22.802 1.00 16.01 ? 109 ALA A O 1 ATOM 689 C CB . ALA A 1 89 ? 27.640 -42.558 -19.591 1.00 16.50 ? 109 ALA A CB 1 ATOM 690 N N . ILE A 1 90 ? 26.643 -43.788 -22.402 1.00 16.02 ? 110 ILE A N 1 ATOM 691 C CA . ILE A 1 90 ? 26.863 -44.483 -23.654 1.00 15.40 ? 110 ILE A CA 1 ATOM 692 C C . ILE A 1 90 ? 26.587 -43.510 -24.823 1.00 15.62 ? 110 ILE A C 1 ATOM 693 O O . ILE A 1 90 ? 27.336 -43.477 -25.778 1.00 16.36 ? 110 ILE A O 1 ATOM 694 C CB . ILE A 1 90 ? 26.045 -45.775 -23.781 1.00 15.16 ? 110 ILE A CB 1 ATOM 695 C CG1 . ILE A 1 90 ? 26.568 -46.835 -22.833 1.00 15.52 ? 110 ILE A CG1 1 ATOM 696 C CG2 . ILE A 1 90 ? 26.063 -46.304 -25.230 1.00 15.40 ? 110 ILE A CG2 1 ATOM 697 C CD1 . ILE A 1 90 ? 28.022 -47.257 -23.035 1.00 16.39 ? 110 ILE A CD1 1 ATOM 698 N N . GLN A 1 91 ? 25.536 -42.722 -24.729 1.00 15.62 ? 111 GLN A N 1 ATOM 699 C CA . GLN A 1 91 ? 25.270 -41.708 -25.731 1.00 16.50 ? 111 GLN A CA 1 ATOM 700 C C . GLN A 1 91 ? 26.440 -40.700 -25.909 1.00 15.74 ? 111 GLN A C 1 ATOM 701 O O . GLN A 1 91 ? 26.941 -40.493 -27.028 1.00 15.26 ? 111 GLN A O 1 ATOM 702 C CB . GLN A 1 91 ? 23.967 -40.960 -25.450 1.00 17.43 ? 111 GLN A CB 1 ATOM 703 C CG . GLN A 1 91 ? 23.683 -39.870 -26.461 1.00 18.76 ? 111 GLN A CG 1 ATOM 704 C CD . GLN A 1 91 ? 22.402 -39.093 -26.165 1.00 21.24 ? 111 GLN A CD 1 ATOM 705 O OE1 . GLN A 1 91 ? 22.082 -38.761 -25.021 1.00 22.44 ? 111 GLN A OE1 1 ATOM 706 N NE2 . GLN A 1 91 ? 21.678 -38.779 -27.216 1.00 22.35 ? 111 GLN A NE2 1 ATOM 707 N N . ASN A 1 92 ? 26.810 -40.075 -24.806 1.00 15.65 ? 112 ASN A N 1 ATOM 708 C CA . ASN A 1 92 ? 27.874 -39.059 -24.757 1.00 17.45 ? 112 ASN A CA 1 ATOM 709 C C . ASN A 1 92 ? 29.215 -39.579 -25.318 1.00 17.51 ? 112 ASN A C 1 ATOM 710 O O . ASN A 1 92 ? 29.777 -39.000 -26.241 1.00 17.07 ? 112 ASN A O 1 ATOM 711 C CB . ASN A 1 92 ? 28.076 -38.618 -23.332 1.00 20.49 ? 112 ASN A CB 1 ATOM 712 C CG . ASN A 1 92 ? 28.919 -37.358 -23.199 1.00 24.03 ? 112 ASN A CG 1 ATOM 713 O OD1 . ASN A 1 92 ? 28.999 -36.557 -24.096 1.00 25.75 ? 112 ASN A OD1 1 ATOM 714 N ND2 . ASN A 1 92 ? 29.532 -37.184 -22.021 1.00 28.03 ? 112 ASN A ND2 1 ATOM 715 N N . TYR A 1 93 ? 29.667 -40.699 -24.792 1.00 16.16 ? 113 TYR A N 1 ATOM 716 C CA . TYR A 1 93 ? 30.973 -41.241 -25.155 1.00 17.79 ? 113 TYR A CA 1 ATOM 717 C C . TYR A 1 93 ? 30.988 -41.859 -26.534 1.00 18.12 ? 113 TYR A C 1 ATOM 718 O O . TYR A 1 93 ? 32.032 -41.818 -27.219 1.00 15.48 ? 113 TYR A O 1 ATOM 719 C CB . TYR A 1 93 ? 31.530 -42.169 -24.069 1.00 16.76 ? 113 TYR A CB 1 ATOM 720 C CG . TYR A 1 93 ? 31.694 -41.344 -22.795 1.00 17.74 ? 113 TYR A CG 1 ATOM 721 C CD1 . TYR A 1 93 ? 32.537 -40.235 -22.771 1.00 18.95 ? 113 TYR A CD1 1 ATOM 722 C CD2 . TYR A 1 93 ? 30.993 -41.632 -21.620 1.00 18.73 ? 113 TYR A CD2 1 ATOM 723 C CE1 . TYR A 1 93 ? 32.682 -39.442 -21.618 1.00 18.29 ? 113 TYR A CE1 1 ATOM 724 C CE2 . TYR A 1 93 ? 31.150 -40.866 -20.467 1.00 17.41 ? 113 TYR A CE2 1 ATOM 725 C CZ . TYR A 1 93 ? 31.975 -39.763 -20.489 1.00 18.72 ? 113 TYR A CZ 1 ATOM 726 O OH . TYR A 1 93 ? 32.116 -38.967 -19.408 1.00 16.70 ? 113 TYR A OH 1 ATOM 727 N N . THR A 1 94 ? 29.859 -42.458 -26.949 1.00 15.95 ? 114 THR A N 1 ATOM 728 C CA . THR A 1 94 ? 29.788 -42.973 -28.310 1.00 15.44 ? 114 THR A CA 1 ATOM 729 C C . THR A 1 94 ? 29.909 -41.782 -29.267 1.00 15.90 ? 114 THR A C 1 ATOM 730 O O . THR A 1 94 ? 30.667 -41.860 -30.253 1.00 16.86 ? 114 THR A O 1 ATOM 731 C CB . THR A 1 94 ? 28.518 -43.781 -28.596 1.00 16.45 ? 114 THR A CB 1 ATOM 732 O OG1 . THR A 1 94 ? 28.474 -44.937 -27.763 1.00 16.00 ? 114 THR A OG1 1 ATOM 733 C CG2 . THR A 1 94 ? 28.477 -44.242 -30.032 1.00 18.29 ? 114 THR A CG2 1 ATOM 734 N N . ASN A 1 95 ? 29.154 -40.724 -29.019 1.00 15.95 ? 115 ASN A N 1 ATOM 735 C CA . ASN A 1 95 ? 29.150 -39.566 -29.885 1.00 17.46 ? 115 ASN A CA 1 ATOM 736 C C . ASN A 1 95 ? 30.505 -38.829 -29.965 1.00 19.34 ? 115 ASN A C 1 ATOM 737 O O . ASN A 1 95 ? 30.922 -38.462 -31.047 1.00 20.99 ? 115 ASN A O 1 ATOM 738 C CB . ASN A 1 95 ? 27.991 -38.631 -29.555 1.00 17.95 ? 115 ASN A CB 1 ATOM 739 C CG . ASN A 1 95 ? 26.638 -39.200 -30.064 1.00 19.50 ? 115 ASN A CG 1 ATOM 740 O OD1 . ASN A 1 95 ? 26.611 -40.160 -30.856 1.00 19.25 ? 115 ASN A OD1 1 ATOM 741 N ND2 . ASN A 1 95 ? 25.554 -38.687 -29.537 1.00 18.62 ? 115 ASN A ND2 1 ATOM 742 N N . ILE A 1 96 ? 31.219 -38.721 -28.847 1.00 18.72 ? 116 ILE A N 1 ATOM 743 C CA . ILE A 1 96 ? 32.630 -38.320 -28.861 1.00 20.25 ? 116 ILE A CA 1 ATOM 744 C C . ILE A 1 96 ? 33.478 -39.162 -29.804 1.00 19.71 ? 116 ILE A C 1 ATOM 745 O O . ILE A 1 96 ? 34.243 -38.616 -30.592 1.00 23.42 ? 116 ILE A O 1 ATOM 746 C CB . ILE A 1 96 ? 33.234 -38.293 -27.445 1.00 21.76 ? 116 ILE A CB 1 ATOM 747 C CG1 . ILE A 1 96 ? 32.671 -37.119 -26.686 1.00 22.31 ? 116 ILE A CG1 1 ATOM 748 C CG2 . ILE A 1 96 ? 34.763 -38.237 -27.493 1.00 24.59 ? 116 ILE A CG2 1 ATOM 749 C CD1 . ILE A 1 96 ? 32.791 -37.251 -25.175 1.00 23.65 ? 116 ILE A CD1 1 ATOM 750 N N . LEU A 1 97 ? 33.348 -40.474 -29.736 1.00 17.06 ? 117 LEU A N 1 ATOM 751 C CA . LEU A 1 97 ? 34.098 -41.331 -30.596 1.00 18.42 ? 117 LEU A CA 1 ATOM 752 C C . LEU A 1 97 ? 33.698 -41.225 -32.103 1.00 24.53 ? 117 LEU A C 1 ATOM 753 O O . LEU A 1 97 ? 34.515 -41.567 -33.005 1.00 24.95 ? 117 LEU A O 1 ATOM 754 C CB . LEU A 1 97 ? 34.037 -42.758 -30.133 1.00 18.84 ? 117 LEU A CB 1 ATOM 755 C CG . LEU A 1 97 ? 34.794 -43.054 -28.828 1.00 18.21 ? 117 LEU A CG 1 ATOM 756 C CD1 . LEU A 1 97 ? 34.378 -44.358 -28.193 1.00 17.77 ? 117 LEU A CD1 1 ATOM 757 C CD2 . LEU A 1 97 ? 36.293 -43.142 -29.097 1.00 19.35 ? 117 LEU A CD2 1 ATOM 758 N N . LEU A 1 98 ? 32.460 -40.776 -32.365 1.00 23.44 ? 118 LEU A N 1 ATOM 759 C CA . LEU A 1 98 ? 31.990 -40.551 -33.735 1.00 23.50 ? 118 LEU A CA 1 ATOM 760 C C . LEU A 1 98 ? 32.404 -39.165 -34.269 1.00 22.67 ? 118 LEU A C 1 ATOM 761 O O . LEU A 1 98 ? 32.673 -39.049 -35.429 1.00 22.35 ? 118 LEU A O 1 ATOM 762 C CB . LEU A 1 98 ? 30.444 -40.743 -33.812 1.00 22.14 ? 118 LEU A CB 1 ATOM 763 C CG . LEU A 1 98 ? 29.917 -42.146 -33.533 1.00 19.88 ? 118 LEU A CG 1 ATOM 764 C CD1 . LEU A 1 98 ? 28.391 -42.119 -33.458 1.00 20.35 ? 118 LEU A CD1 1 ATOM 765 C CD2 . LEU A 1 98 ? 30.366 -43.186 -34.508 1.00 22.55 ? 118 LEU A CD2 1 ATOM 766 N N . GLU A 1 99 ? 32.364 -38.144 -33.418 1.00 21.22 ? 119 GLU A N 1 ATOM 767 C CA . GLU A 1 99 ? 32.614 -36.783 -33.785 1.00 25.38 ? 119 GLU A CA 1 ATOM 768 C C . GLU A 1 99 ? 34.124 -36.453 -33.763 1.00 26.79 ? 119 GLU A C 1 ATOM 769 O O . GLU A 1 99 ? 34.567 -35.558 -34.489 1.00 24.32 ? 119 GLU A O 1 ATOM 770 C CB . GLU A 1 99 ? 31.903 -35.777 -32.848 1.00 30.05 ? 119 GLU A CB 1 ATOM 771 C CG . GLU A 1 99 ? 30.363 -35.604 -32.968 1.00 33.56 ? 119 GLU A CG 1 ATOM 772 C CD . GLU A 1 99 ? 29.928 -34.308 -33.691 0.50 33.84 ? 119 GLU A CD 1 ATOM 773 O OE1 . GLU A 1 99 ? 30.600 -33.271 -33.590 0.50 29.34 ? 119 GLU A OE1 1 ATOM 774 O OE2 . GLU A 1 99 ? 28.884 -34.338 -34.381 0.50 36.01 ? 119 GLU A OE2 1 ATOM 775 N N . SER A 1 100 ? 34.878 -37.146 -32.913 1.00 22.12 ? 120 SER A N 1 ATOM 776 C CA . SER A 1 100 ? 36.284 -36.833 -32.689 1.00 21.90 ? 120 SER A CA 1 ATOM 777 C C . SER A 1 100 ? 37.093 -38.075 -32.291 1.00 19.15 ? 120 SER A C 1 ATOM 778 O O . SER A 1 100 ? 37.719 -38.117 -31.251 1.00 19.08 ? 120 SER A O 1 ATOM 779 C CB . SER A 1 100 ? 36.392 -35.725 -31.638 1.00 24.30 ? 120 SER A CB 1 ATOM 780 O OG . SER A 1 100 ? 37.749 -35.228 -31.584 1.00 29.49 ? 120 SER A OG 1 ATOM 781 N N . PRO A 1 101 ? 37.147 -39.069 -33.169 1.00 19.86 ? 121 PRO A N 1 ATOM 782 C CA . PRO A 1 101 ? 37.877 -40.262 -32.842 1.00 20.40 ? 121 PRO A CA 1 ATOM 783 C C . PRO A 1 101 ? 39.387 -40.079 -32.692 1.00 20.96 ? 121 PRO A C 1 ATOM 784 O O . PRO A 1 101 ? 40.032 -40.953 -32.111 1.00 19.92 ? 121 PRO A O 1 ATOM 785 C CB . PRO A 1 101 ? 37.613 -41.175 -34.048 1.00 21.36 ? 121 PRO A CB 1 ATOM 786 C CG . PRO A 1 101 ? 37.319 -40.273 -35.155 1.00 20.99 ? 121 PRO A CG 1 ATOM 787 C CD . PRO A 1 101 ? 36.583 -39.138 -34.528 1.00 21.77 ? 121 PRO A CD 1 ATOM 788 N N . ASN A 1 102 ? 39.928 -38.973 -33.215 1.00 20.13 ? 122 ASN A N 1 ATOM 789 C CA . ASN A 1 102 ? 41.366 -38.712 -33.087 1.00 22.73 ? 122 ASN A CA 1 ATOM 790 C C . ASN A 1 102 ? 41.702 -37.748 -31.960 1.00 20.41 ? 122 ASN A C 1 ATOM 791 O O . ASN A 1 102 ? 42.868 -37.560 -31.680 1.00 21.41 ? 122 ASN A O 1 ATOM 792 C CB . ASN A 1 102 ? 41.944 -38.195 -34.422 1.00 26.23 ? 122 ASN A CB 1 ATOM 793 C CG . ASN A 1 102 ? 41.675 -39.140 -35.569 1.00 30.30 ? 122 ASN A CG 1 ATOM 794 O OD1 . ASN A 1 102 ? 41.044 -38.749 -36.559 1.00 35.94 ? 122 ASN A OD1 1 ATOM 795 N ND2 . ASN A 1 102 ? 42.039 -40.393 -35.409 1.00 29.62 ? 122 ASN A ND2 1 ATOM 796 N N . GLY A 1 103 ? 40.682 -37.137 -31.335 1.00 16.53 ? 123 GLY A N 1 ATOM 797 C CA . GLY A 1 103 ? 40.883 -36.064 -30.405 1.00 16.18 ? 123 GLY A CA 1 ATOM 798 C C . GLY A 1 103 ? 41.279 -36.556 -29.022 1.00 16.53 ? 123 GLY A C 1 ATOM 799 O O . GLY A 1 103 ? 41.354 -37.776 -28.754 1.00 14.93 ? 123 GLY A O 1 ATOM 800 N N . SER A 1 104 ? 41.510 -35.593 -28.154 1.00 15.07 ? 124 SER A N 1 ATOM 801 C CA . SER A 1 104 ? 42.022 -35.869 -26.813 1.00 17.10 ? 124 SER A CA 1 ATOM 802 C C . SER A 1 104 ? 41.012 -36.599 -25.896 1.00 18.52 ? 124 SER A C 1 ATOM 803 O O . SER A 1 104 ? 41.408 -37.277 -24.931 1.00 17.49 ? 124 SER A O 1 ATOM 804 C CB . SER A 1 104 ? 42.517 -34.594 -26.119 1.00 15.64 ? 124 SER A CB 1 ATOM 805 O OG . SER A 1 104 ? 41.468 -33.718 -25.797 1.00 16.63 ? 124 SER A OG 1 ATOM 806 N N . GLU A 1 105 ? 39.732 -36.497 -26.218 1.00 18.15 ? 125 GLU A N 1 ATOM 807 C CA . GLU A 1 105 ? 38.680 -37.104 -25.394 1.00 20.71 ? 125 GLU A CA 1 ATOM 808 C C . GLU A 1 105 ? 38.431 -38.595 -25.787 1.00 17.93 ? 125 GLU A C 1 ATOM 809 O O . GLU A 1 105 ? 37.794 -39.317 -25.057 1.00 15.36 ? 125 GLU A O 1 ATOM 810 C CB A GLU A 1 105 ? 37.338 -36.368 -25.432 0.50 22.90 ? 125 GLU A CB 1 ATOM 811 C CB B GLU A 1 105 ? 37.469 -36.117 -25.419 0.50 22.25 ? 125 GLU A CB 1 ATOM 812 C CG A GLU A 1 105 ? 37.240 -35.135 -24.562 0.50 25.54 ? 125 GLU A CG 1 ATOM 813 C CG B GLU A 1 105 ? 37.971 -34.650 -25.298 0.50 24.48 ? 125 GLU A CG 1 ATOM 814 C CD A GLU A 1 105 ? 35.786 -34.678 -24.496 0.50 29.62 ? 125 GLU A CD 1 ATOM 815 C CD B GLU A 1 105 ? 36.988 -33.571 -24.828 0.50 28.13 ? 125 GLU A CD 1 ATOM 816 O OE1 A GLU A 1 105 ? 35.202 -34.336 -25.557 0.50 28.92 ? 125 GLU A OE1 1 ATOM 817 O OE1 B GLU A 1 105 ? 35.768 -33.733 -25.003 0.50 31.77 ? 125 GLU A OE1 1 ATOM 818 O OE2 A GLU A 1 105 ? 35.208 -34.751 -23.384 0.50 33.53 ? 125 GLU A OE2 1 ATOM 819 O OE2 B GLU A 1 105 ? 37.467 -32.517 -24.309 0.50 29.86 ? 125 GLU A OE2 1 ATOM 820 N N . ALA A 1 106 ? 39.024 -39.081 -26.873 1.00 15.92 ? 126 ALA A N 1 ATOM 821 C CA . ALA A 1 106 ? 38.678 -40.398 -27.409 1.00 15.13 ? 126 ALA A CA 1 ATOM 822 C C . ALA A 1 106 ? 39.163 -41.523 -26.501 1.00 16.24 ? 126 ALA A C 1 ATOM 823 O O . ALA A 1 106 ? 38.446 -42.533 -26.325 1.00 13.17 ? 126 ALA A O 1 ATOM 824 C CB . ALA A 1 106 ? 39.204 -40.594 -28.827 1.00 15.71 ? 126 ALA A CB 1 ATOM 825 N N . LEU A 1 107 ? 40.364 -41.337 -25.900 1.00 14.72 ? 127 LEU A N 1 ATOM 826 C CA . LEU A 1 107 ? 40.871 -42.312 -24.973 1.00 14.88 ? 127 LEU A CA 1 ATOM 827 C C . LEU A 1 107 ? 39.872 -42.634 -23.817 1.00 14.30 ? 127 LEU A C 1 ATOM 828 O O . LEU A 1 107 ? 39.574 -43.804 -23.557 1.00 13.53 ? 127 LEU A O 1 ATOM 829 C CB . LEU A 1 107 ? 42.206 -41.848 -24.361 1.00 17.19 ? 127 LEU A CB 1 ATOM 830 C CG . LEU A 1 107 ? 42.744 -42.643 -23.162 1.00 17.08 ? 127 LEU A CG 1 ATOM 831 C CD1 . LEU A 1 107 ? 43.012 -44.075 -23.582 1.00 17.99 ? 127 LEU A CD1 1 ATOM 832 C CD2 . LEU A 1 107 ? 44.040 -42.010 -22.609 1.00 18.33 ? 127 LEU A CD2 1 ATOM 833 N N . ASN A 1 108 ? 39.453 -41.612 -23.090 1.00 14.27 ? 128 ASN A N 1 ATOM 834 C CA . ASN A 1 108 ? 38.557 -41.844 -21.977 1.00 14.80 ? 128 ASN A CA 1 ATOM 835 C C . ASN A 1 108 ? 37.183 -42.365 -22.479 1.00 14.97 ? 128 ASN A C 1 ATOM 836 O O . ASN A 1 108 ? 36.597 -43.259 -21.848 1.00 14.96 ? 128 ASN A O 1 ATOM 837 C CB . ASN A 1 108 ? 38.423 -40.623 -21.121 1.00 14.70 ? 128 ASN A CB 1 ATOM 838 C CG . ASN A 1 108 ? 39.671 -40.384 -20.252 1.00 14.34 ? 128 ASN A CG 1 ATOM 839 O OD1 . ASN A 1 108 ? 40.614 -41.178 -20.252 1.00 14.80 ? 128 ASN A OD1 1 ATOM 840 N ND2 . ASN A 1 108 ? 39.617 -39.344 -19.455 1.00 13.65 ? 128 ASN A ND2 1 ATOM 841 N N . ALA A 1 109 ? 36.720 -41.817 -23.596 1.00 13.55 ? 129 ALA A N 1 ATOM 842 C CA . ALA A 1 109 ? 35.423 -42.237 -24.183 1.00 14.54 ? 129 ALA A CA 1 ATOM 843 C C . ALA A 1 109 ? 35.403 -43.708 -24.503 1.00 15.55 ? 129 ALA A C 1 ATOM 844 O O . ALA A 1 109 ? 34.447 -44.413 -24.166 1.00 13.70 ? 129 ALA A O 1 ATOM 845 C CB . ALA A 1 109 ? 35.072 -41.395 -25.386 1.00 14.80 ? 129 ALA A CB 1 ATOM 846 N N . LEU A 1 110 ? 36.512 -44.227 -25.048 1.00 14.73 ? 130 LEU A N 1 ATOM 847 C CA . LEU A 1 110 ? 36.600 -45.617 -25.344 1.00 13.85 ? 130 LEU A CA 1 ATOM 848 C C . LEU A 1 110 ? 36.642 -46.470 -24.104 1.00 13.58 ? 130 LEU A C 1 ATOM 849 O O . LEU A 1 110 ? 35.958 -47.530 -24.019 1.00 13.98 ? 130 LEU A O 1 ATOM 850 C CB . LEU A 1 110 ? 37.790 -45.920 -26.277 1.00 13.93 ? 130 LEU A CB 1 ATOM 851 C CG . LEU A 1 110 ? 38.083 -47.354 -26.619 1.00 15.64 ? 130 LEU A CG 1 ATOM 852 C CD1 . LEU A 1 110 ? 36.850 -48.000 -27.270 1.00 16.57 ? 130 LEU A CD1 1 ATOM 853 C CD2 . LEU A 1 110 ? 39.247 -47.426 -27.612 1.00 16.37 ? 130 LEU A CD2 1 ATOM 854 N N . LYS A 1 111 ? 37.443 -46.067 -23.124 1.00 12.23 ? 131 LYS A N 1 ATOM 855 C CA . LYS A 1 111 ? 37.523 -46.814 -21.904 1.00 12.63 ? 131 LYS A CA 1 ATOM 856 C C . LYS A 1 111 ? 36.128 -46.828 -21.184 1.00 11.59 ? 131 LYS A C 1 ATOM 857 O O . LYS A 1 111 ? 35.730 -47.845 -20.639 1.00 11.92 ? 131 LYS A O 1 ATOM 858 C CB . LYS A 1 111 ? 38.600 -46.240 -20.985 1.00 12.62 ? 131 LYS A CB 1 ATOM 859 C CG . LYS A 1 111 ? 40.006 -46.429 -21.561 1.00 13.46 ? 131 LYS A CG 1 ATOM 860 C CD . LYS A 1 111 ? 41.090 -46.174 -20.540 1.00 13.54 ? 131 LYS A CD 1 ATOM 861 C CE . LYS A 1 111 ? 41.290 -44.715 -20.246 1.00 13.64 ? 131 LYS A CE 1 ATOM 862 N NZ . LYS A 1 111 ? 42.580 -44.642 -19.449 1.00 13.89 ? 131 LYS A NZ 1 ATOM 863 N N . PHE A 1 112 ? 35.437 -45.711 -21.224 1.00 11.95 ? 132 PHE A N 1 ATOM 864 C CA . PHE A 1 112 ? 34.043 -45.654 -20.694 1.00 13.34 ? 132 PHE A CA 1 ATOM 865 C C . PHE A 1 112 ? 33.085 -46.645 -21.388 1.00 13.31 ? 132 PHE A C 1 ATOM 866 O O . PHE A 1 112 ? 32.347 -47.388 -20.708 1.00 13.22 ? 132 PHE A O 1 ATOM 867 C CB . PHE A 1 112 ? 33.422 -44.261 -20.831 1.00 13.32 ? 132 PHE A CB 1 ATOM 868 C CG . PHE A 1 112 ? 33.747 -43.315 -19.723 1.00 13.55 ? 132 PHE A CG 1 ATOM 869 C CD1 . PHE A 1 112 ? 33.430 -43.626 -18.424 1.00 14.99 ? 132 PHE A CD1 1 ATOM 870 C CD2 . PHE A 1 112 ? 34.341 -42.067 -19.985 1.00 14.28 ? 132 PHE A CD2 1 ATOM 871 C CE1 . PHE A 1 112 ? 33.737 -42.760 -17.378 1.00 14.90 ? 132 PHE A CE1 1 ATOM 872 C CE2 . PHE A 1 112 ? 34.606 -41.166 -18.950 1.00 14.79 ? 132 PHE A CE2 1 ATOM 873 C CZ . PHE A 1 112 ? 34.301 -41.525 -17.639 1.00 15.25 ? 132 PHE A CZ 1 ATOM 874 N N . VAL A 1 113 ? 33.122 -46.673 -22.725 1.00 13.50 ? 133 VAL A N 1 ATOM 875 C CA . VAL A 1 113 ? 32.235 -47.585 -23.491 1.00 13.56 ? 133 VAL A CA 1 ATOM 876 C C . VAL A 1 113 ? 32.499 -49.058 -23.137 1.00 13.82 ? 133 VAL A C 1 ATOM 877 O O . VAL A 1 113 ? 31.574 -49.861 -22.917 1.00 13.43 ? 133 VAL A O 1 ATOM 878 C CB . VAL A 1 113 ? 32.376 -47.339 -25.007 1.00 14.25 ? 133 VAL A CB 1 ATOM 879 C CG1 . VAL A 1 113 ? 31.728 -48.429 -25.835 1.00 14.22 ? 133 VAL A CG1 1 ATOM 880 C CG2 . VAL A 1 113 ? 31.763 -45.978 -25.320 1.00 14.19 ? 133 VAL A CG2 1 ATOM 881 N N . VAL A 1 114 ? 33.769 -49.425 -23.088 1.00 12.58 ? 134 VAL A N 1 ATOM 882 C CA . VAL A 1 114 ? 34.160 -50.785 -22.781 1.00 13.19 ? 134 VAL A CA 1 ATOM 883 C C . VAL A 1 114 ? 33.626 -51.225 -21.395 1.00 13.56 ? 134 VAL A C 1 ATOM 884 O O . VAL A 1 114 ? 33.146 -52.358 -21.206 1.00 14.08 ? 134 VAL A O 1 ATOM 885 C CB . VAL A 1 114 ? 35.709 -50.927 -22.799 1.00 12.90 ? 134 VAL A CB 1 ATOM 886 C CG1 . VAL A 1 114 ? 36.155 -52.272 -22.194 1.00 13.62 ? 134 VAL A CG1 1 ATOM 887 C CG2 . VAL A 1 114 ? 36.268 -50.796 -24.203 1.00 14.00 ? 134 VAL A CG2 1 ATOM 888 N N . HIS A 1 115 ? 33.801 -50.352 -20.415 1.00 13.22 ? 135 HIS A N 1 ATOM 889 C CA . HIS A 1 115 ? 33.377 -50.657 -19.065 1.00 13.37 ? 135 HIS A CA 1 ATOM 890 C C . HIS A 1 115 ? 31.833 -50.669 -18.937 1.00 13.50 ? 135 HIS A C 1 ATOM 891 O O . HIS A 1 115 ? 31.264 -51.578 -18.373 1.00 12.41 ? 135 HIS A O 1 ATOM 892 C CB . HIS A 1 115 ? 33.966 -49.649 -18.067 1.00 13.84 ? 135 HIS A CB 1 ATOM 893 C CG . HIS A 1 115 ? 33.595 -49.940 -16.647 1.00 12.90 ? 135 HIS A CG 1 ATOM 894 N ND1 . HIS A 1 115 ? 34.313 -50.800 -15.872 1.00 14.12 ? 135 HIS A ND1 1 ATOM 895 C CD2 . HIS A 1 115 ? 32.569 -49.500 -15.880 1.00 13.62 ? 135 HIS A CD2 1 ATOM 896 C CE1 . HIS A 1 115 ? 33.761 -50.884 -14.672 1.00 15.24 ? 135 HIS A CE1 1 ATOM 897 N NE2 . HIS A 1 115 ? 32.709 -50.088 -14.650 1.00 14.14 ? 135 HIS A NE2 1 ATOM 898 N N . ILE A 1 116 ? 31.199 -49.644 -19.484 1.00 14.28 ? 136 ILE A N 1 ATOM 899 C CA . ILE A 1 116 ? 29.793 -49.380 -19.206 1.00 14.04 ? 136 ILE A CA 1 ATOM 900 C C . ILE A 1 116 ? 28.891 -50.381 -19.968 1.00 14.55 ? 136 ILE A C 1 ATOM 901 O O . ILE A 1 116 ? 27.939 -50.852 -19.412 1.00 12.21 ? 136 ILE A O 1 ATOM 902 C CB . ILE A 1 116 ? 29.421 -47.923 -19.467 1.00 13.92 ? 136 ILE A CB 1 ATOM 903 C CG1 . ILE A 1 116 ? 30.127 -47.030 -18.463 1.00 14.47 ? 136 ILE A CG1 1 ATOM 904 C CG2 . ILE A 1 116 ? 27.916 -47.736 -19.346 1.00 14.91 ? 136 ILE A CG2 1 ATOM 905 C CD1 . ILE A 1 116 ? 30.033 -45.553 -18.806 1.00 15.68 ? 136 ILE A CD1 1 ATOM 906 N N . ILE A 1 117 ? 29.281 -50.776 -21.186 1.00 14.43 ? 137 ILE A N 1 ATOM 907 C CA . ILE A 1 117 ? 28.529 -51.828 -21.867 1.00 15.75 ? 137 ILE A CA 1 ATOM 908 C C . ILE A 1 117 ? 28.584 -53.080 -20.982 1.00 15.36 ? 137 ILE A C 1 ATOM 909 O O . ILE A 1 117 ? 27.572 -53.762 -20.820 1.00 16.66 ? 137 ILE A O 1 ATOM 910 C CB . ILE A 1 117 ? 28.985 -52.076 -23.313 1.00 14.86 ? 137 ILE A CB 1 ATOM 911 C CG1 . ILE A 1 117 ? 28.551 -50.881 -24.136 1.00 15.75 ? 137 ILE A CG1 1 ATOM 912 C CG2 . ILE A 1 117 ? 28.372 -53.361 -23.849 1.00 16.10 ? 137 ILE A CG2 1 ATOM 913 C CD1 . ILE A 1 117 ? 28.988 -50.952 -25.584 1.00 18.52 ? 137 ILE A CD1 1 ATOM 914 N N . GLY A 1 118 ? 29.711 -53.337 -20.334 1.00 15.14 ? 138 GLY A N 1 ATOM 915 C CA . GLY A 1 118 ? 29.784 -54.450 -19.361 1.00 14.47 ? 138 GLY A CA 1 ATOM 916 C C . GLY A 1 118 ? 28.749 -54.239 -18.240 1.00 14.70 ? 138 GLY A C 1 ATOM 917 O O . GLY A 1 118 ? 27.947 -55.145 -17.925 1.00 15.29 ? 138 GLY A O 1 ATOM 918 N N . ASP A 1 119 ? 28.829 -53.091 -17.589 1.00 13.72 ? 139 ASP A N 1 ATOM 919 C CA . ASP A 1 119 ? 28.012 -52.811 -16.374 1.00 14.17 ? 139 ASP A CA 1 ATOM 920 C C . ASP A 1 119 ? 26.490 -52.877 -16.643 1.00 14.95 ? 139 ASP A C 1 ATOM 921 O O . ASP A 1 119 ? 25.750 -53.429 -15.830 1.00 15.12 ? 139 ASP A O 1 ATOM 922 C CB . ASP A 1 119 ? 28.337 -51.435 -15.807 1.00 13.55 ? 139 ASP A CB 1 ATOM 923 C CG . ASP A 1 119 ? 29.341 -51.438 -14.703 1.00 12.39 ? 139 ASP A CG 1 ATOM 924 O OD1 . ASP A 1 119 ? 29.771 -52.527 -14.207 1.00 13.49 ? 139 ASP A OD1 1 ATOM 925 O OD2 . ASP A 1 119 ? 29.729 -50.298 -14.355 1.00 11.97 ? 139 ASP A OD2 1 ATOM 926 N N . ILE A 1 120 ? 26.070 -52.399 -17.816 1.00 14.31 ? 140 ILE A N 1 ATOM 927 C CA . ILE A 1 120 ? 24.673 -52.486 -18.255 1.00 14.04 ? 140 ILE A CA 1 ATOM 928 C C . ILE A 1 120 ? 24.134 -53.901 -18.165 1.00 14.81 ? 140 ILE A C 1 ATOM 929 O O . ILE A 1 120 ? 22.930 -54.118 -17.864 1.00 15.93 ? 140 ILE A O 1 ATOM 930 C CB . ILE A 1 120 ? 24.466 -51.874 -19.659 1.00 15.28 ? 140 ILE A CB 1 ATOM 931 C CG1 . ILE A 1 120 ? 24.635 -50.345 -19.574 1.00 15.22 ? 140 ILE A CG1 1 ATOM 932 C CG2 . ILE A 1 120 ? 23.086 -52.255 -20.264 1.00 14.64 ? 140 ILE A CG2 1 ATOM 933 C CD1 . ILE A 1 120 ? 24.795 -49.677 -20.916 1.00 15.93 ? 140 ILE A CD1 1 ATOM 934 N N . HIS A 1 121 ? 24.971 -54.871 -18.459 1.00 14.83 ? 141 HIS A N 1 ATOM 935 C CA . HIS A 1 121 ? 24.576 -56.268 -18.467 1.00 14.61 ? 141 HIS A CA 1 ATOM 936 C C . HIS A 1 121 ? 24.528 -56.967 -17.096 1.00 15.15 ? 141 HIS A C 1 ATOM 937 O O . HIS A 1 121 ? 24.142 -58.133 -17.024 1.00 14.49 ? 141 HIS A O 1 ATOM 938 C CB . HIS A 1 121 ? 25.450 -57.074 -19.449 1.00 14.31 ? 141 HIS A CB 1 ATOM 939 C CG . HIS A 1 121 ? 25.113 -56.795 -20.854 1.00 14.26 ? 141 HIS A CG 1 ATOM 940 N ND1 . HIS A 1 121 ? 25.522 -55.645 -21.488 1.00 14.83 ? 141 HIS A ND1 1 ATOM 941 C CD2 . HIS A 1 121 ? 24.325 -57.458 -21.734 1.00 14.56 ? 141 HIS A CD2 1 ATOM 942 C CE1 . HIS A 1 121 ? 25.020 -55.620 -22.705 1.00 15.40 ? 141 HIS A CE1 1 ATOM 943 N NE2 . HIS A 1 121 ? 24.285 -56.712 -22.865 1.00 15.05 ? 141 HIS A NE2 1 ATOM 944 N N . GLN A 1 122 ? 24.933 -56.279 -16.040 1.00 14.96 ? 142 GLN A N 1 ATOM 945 C CA . GLN A 1 122 ? 24.829 -56.775 -14.693 1.00 14.65 ? 142 GLN A CA 1 ATOM 946 C C . GLN A 1 122 ? 23.442 -56.307 -14.203 1.00 14.72 ? 142 GLN A C 1 ATOM 947 O O . GLN A 1 122 ? 23.235 -55.109 -14.078 1.00 14.58 ? 142 GLN A O 1 ATOM 948 C CB . GLN A 1 122 ? 25.951 -56.205 -13.813 1.00 14.38 ? 142 GLN A CB 1 ATOM 949 C CG . GLN A 1 122 ? 26.344 -57.043 -12.609 1.00 15.32 ? 142 GLN A CG 1 ATOM 950 C CD . GLN A 1 122 ? 25.325 -56.974 -11.423 1.00 17.63 ? 142 GLN A CD 1 ATOM 951 O OE1 . GLN A 1 122 ? 24.158 -57.376 -11.577 1.00 18.15 ? 142 GLN A OE1 1 ATOM 952 N NE2 . GLN A 1 122 ? 25.762 -56.504 -10.290 1.00 16.35 ? 142 GLN A NE2 1 ATOM 953 N N . PRO A 1 123 ? 22.469 -57.250 -14.032 1.00 15.74 ? 143 PRO A N 1 ATOM 954 C CA . PRO A 1 123 ? 21.053 -56.864 -13.762 1.00 16.33 ? 143 PRO A CA 1 ATOM 955 C C . PRO A 1 123 ? 20.862 -55.825 -12.672 1.00 15.66 ? 143 PRO A C 1 ATOM 956 O O . PRO A 1 123 ? 20.083 -54.915 -12.864 1.00 13.07 ? 143 PRO A O 1 ATOM 957 C CB . PRO A 1 123 ? 20.395 -58.178 -13.360 1.00 15.99 ? 143 PRO A CB 1 ATOM 958 C CG . PRO A 1 123 ? 21.180 -59.212 -14.129 1.00 17.52 ? 143 PRO A CG 1 ATOM 959 C CD . PRO A 1 123 ? 22.615 -58.722 -13.989 1.00 17.06 ? 143 PRO A CD 1 ATOM 960 N N . LEU A 1 124 ? 21.634 -55.917 -11.573 1.00 15.63 ? 144 LEU A N 1 ATOM 961 C CA . LEU A 1 124 ? 21.529 -54.942 -10.470 1.00 15.73 ? 144 LEU A CA 1 ATOM 962 C C . LEU A 1 124 ? 22.059 -53.527 -10.774 1.00 15.29 ? 144 LEU A C 1 ATOM 963 O O . LEU A 1 124 ? 21.799 -52.567 -10.023 1.00 15.19 ? 144 LEU A O 1 ATOM 964 C CB . LEU A 1 124 ? 22.105 -55.493 -9.186 1.00 16.52 ? 144 LEU A CB 1 ATOM 965 C CG . LEU A 1 124 ? 21.175 -56.520 -8.491 1.00 17.07 ? 144 LEU A CG 1 ATOM 966 C CD1 . LEU A 1 124 ? 21.902 -57.232 -7.364 1.00 17.79 ? 144 LEU A CD1 1 ATOM 967 C CD2 . LEU A 1 124 ? 19.898 -55.844 -7.959 1.00 16.91 ? 144 LEU A CD2 1 ATOM 968 N N . HIS A 1 125 ? 22.748 -53.385 -11.912 1.00 15.14 ? 145 HIS A N 1 ATOM 969 C CA . HIS A 1 125 ? 23.068 -52.030 -12.472 1.00 14.25 ? 145 HIS A CA 1 ATOM 970 C C . HIS A 1 125 ? 21.927 -51.427 -13.238 1.00 14.44 ? 145 HIS A C 1 ATOM 971 O O . HIS A 1 125 ? 22.066 -50.365 -13.831 1.00 13.40 ? 145 HIS A O 1 ATOM 972 C CB . HIS A 1 125 ? 24.296 -52.175 -13.401 1.00 15.43 ? 145 HIS A CB 1 ATOM 973 C CG . HIS A 1 125 ? 25.596 -52.227 -12.653 1.00 14.82 ? 145 HIS A CG 1 ATOM 974 N ND1 . HIS A 1 125 ? 26.496 -51.193 -12.698 1.00 15.27 ? 145 HIS A ND1 1 ATOM 975 C CD2 . HIS A 1 125 ? 26.113 -53.140 -11.808 1.00 14.57 ? 145 HIS A CD2 1 ATOM 976 C CE1 . HIS A 1 125 ? 27.512 -51.463 -11.902 1.00 14.33 ? 145 HIS A CE1 1 ATOM 977 N NE2 . HIS A 1 125 ? 27.314 -52.643 -11.371 1.00 14.69 ? 145 HIS A NE2 1 ATOM 978 N N . ASP A 1 126 ? 20.791 -52.138 -13.302 1.00 14.94 ? 146 ASP A N 1 ATOM 979 C CA . ASP A 1 126 ? 19.567 -51.617 -13.961 1.00 14.96 ? 146 ASP A CA 1 ATOM 980 C C . ASP A 1 126 ? 18.360 -51.682 -12.968 1.00 16.45 ? 146 ASP A C 1 ATOM 981 O O . ASP A 1 126 ? 17.266 -52.101 -13.355 1.00 16.23 ? 146 ASP A O 1 ATOM 982 C CB . ASP A 1 126 ? 19.250 -52.460 -15.216 1.00 13.75 ? 146 ASP A CB 1 ATOM 983 C CG . ASP A 1 126 ? 20.451 -52.571 -16.199 1.00 14.66 ? 146 ASP A CG 1 ATOM 984 O OD1 . ASP A 1 126 ? 20.705 -51.570 -16.910 1.00 13.94 ? 146 ASP A OD1 1 ATOM 985 O OD2 . ASP A 1 126 ? 21.108 -53.650 -16.223 1.00 13.03 ? 146 ASP A OD2 1 ATOM 986 N N . GLU A 1 127 ? 18.593 -51.283 -11.724 1.00 16.73 ? 147 GLU A N 1 ATOM 987 C CA . GLU A 1 127 ? 17.619 -51.438 -10.654 1.00 17.97 ? 147 GLU A CA 1 ATOM 988 C C . GLU A 1 127 ? 17.857 -50.453 -9.502 1.00 17.60 ? 147 GLU A C 1 ATOM 989 O O . GLU A 1 127 ? 18.979 -50.368 -8.962 1.00 16.91 ? 147 GLU A O 1 ATOM 990 C CB . GLU A 1 127 ? 17.664 -52.861 -10.110 1.00 19.28 ? 147 GLU A CB 1 ATOM 991 C CG . GLU A 1 127 ? 16.726 -53.111 -8.924 1.00 18.24 ? 147 GLU A CG 1 ATOM 992 C CD . GLU A 1 127 ? 15.279 -52.699 -9.240 1.00 16.71 ? 147 GLU A CD 1 ATOM 993 O OE1 . GLU A 1 127 ? 14.826 -53.109 -10.314 1.00 16.20 ? 147 GLU A OE1 1 ATOM 994 O OE2 . GLU A 1 127 ? 14.661 -51.927 -8.457 1.00 17.31 ? 147 GLU A OE2 1 ATOM 995 N N . ASN A 1 128 ? 16.821 -49.694 -9.157 1.00 16.47 ? 148 ASN A N 1 ATOM 996 C CA . ASN A 1 128 ? 16.941 -48.682 -8.092 1.00 19.05 ? 148 ASN A CA 1 ATOM 997 C C . ASN A 1 128 ? 17.029 -49.261 -6.700 1.00 18.70 ? 148 ASN A C 1 ATOM 998 O O . ASN A 1 128 ? 17.791 -48.760 -5.853 1.00 20.65 ? 148 ASN A O 1 ATOM 999 C CB . ASN A 1 128 ? 15.804 -47.677 -8.158 1.00 20.95 ? 148 ASN A CB 1 ATOM 1000 C CG . ASN A 1 128 ? 16.014 -46.527 -7.221 1.00 23.03 ? 148 ASN A CG 1 ATOM 1001 O OD1 . ASN A 1 128 ? 16.997 -45.834 -7.282 1.00 20.57 ? 148 ASN A OD1 1 ATOM 1002 N ND2 . ASN A 1 128 ? 15.059 -46.329 -6.317 1.00 21.87 ? 148 ASN A ND2 1 ATOM 1003 N N . LEU A 1 129 ? 16.309 -50.352 -6.483 1.00 19.27 ? 149 LEU A N 1 ATOM 1004 C CA . LEU A 1 129 ? 16.107 -50.881 -5.113 1.00 19.96 ? 149 LEU A CA 1 ATOM 1005 C C . LEU A 1 129 ? 17.397 -50.990 -4.305 1.00 19.93 ? 149 LEU A C 1 ATOM 1006 O O . LEU A 1 129 ? 18.341 -51.683 -4.720 1.00 18.21 ? 149 LEU A O 1 ATOM 1007 C CB . LEU A 1 129 ? 15.414 -52.256 -5.144 1.00 19.99 ? 149 LEU A CB 1 ATOM 1008 C CG . LEU A 1 129 ? 15.102 -52.904 -3.779 1.00 20.75 ? 149 LEU A CG 1 ATOM 1009 C CD1 . LEU A 1 129 ? 14.077 -52.072 -2.969 1.00 20.47 ? 149 LEU A CD1 1 ATOM 1010 C CD2 . LEU A 1 129 ? 14.611 -54.338 -3.956 1.00 19.76 ? 149 LEU A CD2 1 ATOM 1011 N N . GLU A 1 130 ? 17.383 -50.326 -3.135 1.00 19.82 ? 150 GLU A N 1 ATOM 1012 C CA A GLU A 1 130 ? 18.494 -50.342 -2.183 0.50 20.21 ? 150 GLU A CA 1 ATOM 1013 C CA B GLU A 1 130 ? 18.494 -50.339 -2.180 0.50 20.50 ? 150 GLU A CA 1 ATOM 1014 C C . GLU A 1 130 ? 19.866 -50.136 -2.865 1.00 21.16 ? 150 GLU A C 1 ATOM 1015 O O . GLU A 1 130 ? 20.779 -50.938 -2.689 1.00 19.93 ? 150 GLU A O 1 ATOM 1016 C CB A GLU A 1 130 ? 18.467 -51.671 -1.410 0.50 21.41 ? 150 GLU A CB 1 ATOM 1017 C CB B GLU A 1 130 ? 18.450 -51.655 -1.381 0.50 22.28 ? 150 GLU A CB 1 ATOM 1018 C CG A GLU A 1 130 ? 17.229 -51.857 -0.563 0.50 21.85 ? 150 GLU A CG 1 ATOM 1019 C CG B GLU A 1 130 ? 17.148 -51.809 -0.594 0.50 23.03 ? 150 GLU A CG 1 ATOM 1020 C CD A GLU A 1 130 ? 17.433 -51.230 0.782 0.50 21.27 ? 150 GLU A CD 1 ATOM 1021 C CD B GLU A 1 130 ? 17.262 -52.728 0.581 0.50 23.51 ? 150 GLU A CD 1 ATOM 1022 O OE1 A GLU A 1 130 ? 16.490 -51.312 1.593 0.50 22.98 ? 150 GLU A OE1 1 ATOM 1023 O OE1 B GLU A 1 130 ? 18.308 -52.666 1.242 0.50 20.84 ? 150 GLU A OE1 1 ATOM 1024 O OE2 A GLU A 1 130 ? 18.523 -50.621 1.000 0.50 21.97 ? 150 GLU A OE2 1 ATOM 1025 O OE2 B GLU A 1 130 ? 16.288 -53.482 0.843 0.50 25.18 ? 150 GLU A OE2 1 ATOM 1026 N N . ALA A 1 131 ? 19.949 -49.078 -3.659 1.00 19.76 ? 151 ALA A N 1 ATOM 1027 C CA . ALA A 1 131 ? 21.108 -48.688 -4.440 1.00 20.44 ? 151 ALA A CA 1 ATOM 1028 C C . ALA A 1 131 ? 21.683 -49.826 -5.280 1.00 19.03 ? 151 ALA A C 1 ATOM 1029 O O . ALA A 1 131 ? 22.831 -50.220 -5.085 1.00 16.88 ? 151 ALA A O 1 ATOM 1030 C CB . ALA A 1 131 ? 22.171 -48.095 -3.500 1.00 22.10 ? 151 ALA A CB 1 ATOM 1031 N N . GLY A 1 132 ? 20.833 -50.401 -6.137 1.00 16.53 ? 152 GLY A N 1 ATOM 1032 C CA . GLY A 1 132 ? 21.209 -51.546 -6.941 1.00 17.40 ? 152 GLY A CA 1 ATOM 1033 C C . GLY A 1 132 ? 21.568 -52.801 -6.140 1.00 17.08 ? 152 GLY A C 1 ATOM 1034 O O . GLY A 1 132 ? 22.428 -53.581 -6.519 1.00 16.07 ? 152 GLY A O 1 ATOM 1035 N N . GLY A 1 133 ? 20.894 -52.973 -5.012 1.00 15.38 ? 153 GLY A N 1 ATOM 1036 C CA . GLY A 1 133 ? 21.134 -54.120 -4.153 1.00 16.10 ? 153 GLY A CA 1 ATOM 1037 C C . GLY A 1 133 ? 22.325 -53.946 -3.232 1.00 16.31 ? 153 GLY A C 1 ATOM 1038 O O . GLY A 1 133 ? 22.636 -54.856 -2.485 1.00 19.43 ? 153 GLY A O 1 ATOM 1039 N N . ASN A 1 134 ? 22.988 -52.789 -3.246 1.00 16.42 ? 154 ASN A N 1 ATOM 1040 C CA . ASN A 1 134 ? 24.111 -52.569 -2.324 1.00 18.03 ? 154 ASN A CA 1 ATOM 1041 C C . ASN A 1 134 ? 23.678 -52.599 -0.854 1.00 19.73 ? 154 ASN A C 1 ATOM 1042 O O . ASN A 1 134 ? 24.420 -53.038 -0.013 1.00 19.65 ? 154 ASN A O 1 ATOM 1043 C CB . ASN A 1 134 ? 24.862 -51.277 -2.654 1.00 18.69 ? 154 ASN A CB 1 ATOM 1044 C CG . ASN A 1 134 ? 25.889 -51.486 -3.791 1.00 19.68 ? 154 ASN A CG 1 ATOM 1045 O OD1 . ASN A 1 134 ? 26.927 -52.135 -3.590 1.00 19.18 ? 154 ASN A OD1 1 ATOM 1046 N ND2 . ASN A 1 134 ? 25.565 -51.008 -4.988 1.00 18.46 ? 154 ASN A ND2 1 ATOM 1047 N N . GLY A 1 135 ? 22.438 -52.168 -0.608 1.00 19.92 ? 155 GLY A N 1 ATOM 1048 C CA . GLY A 1 135 ? 21.891 -52.098 0.736 1.00 21.73 ? 155 GLY A CA 1 ATOM 1049 C C . GLY A 1 135 ? 21.353 -53.418 1.243 1.00 23.06 ? 155 GLY A C 1 ATOM 1050 O O . GLY A 1 135 ? 20.923 -53.496 2.367 1.00 24.91 ? 155 GLY A O 1 ATOM 1051 N N . ILE A 1 136 ? 21.379 -54.458 0.427 1.00 23.73 ? 156 ILE A N 1 ATOM 1052 C CA . ILE A 1 136 ? 20.862 -55.753 0.832 1.00 22.87 ? 156 ILE A CA 1 ATOM 1053 C C . ILE A 1 136 ? 21.982 -56.683 1.355 1.00 24.65 ? 156 ILE A C 1 ATOM 1054 O O . ILE A 1 136 ? 22.745 -57.233 0.568 1.00 21.03 ? 156 ILE A O 1 ATOM 1055 C CB . ILE A 1 136 ? 20.114 -56.423 -0.329 1.00 22.08 ? 156 ILE A CB 1 ATOM 1056 C CG1 . ILE A 1 136 ? 19.017 -55.493 -0.851 1.00 21.52 ? 156 ILE A CG1 1 ATOM 1057 C CG2 . ILE A 1 136 ? 19.578 -57.762 0.107 1.00 23.20 ? 156 ILE A CG2 1 ATOM 1058 C CD1 . ILE A 1 136 ? 18.259 -55.999 -2.058 1.00 21.82 ? 156 ILE A CD1 1 ATOM 1059 N N . ASP A 1 137 ? 22.071 -56.851 2.679 1.00 23.11 ? 157 ASP A N 1 ATOM 1060 C CA . ASP A 1 137 ? 23.089 -57.729 3.271 1.00 27.60 ? 157 ASP A CA 1 ATOM 1061 C C . ASP A 1 137 ? 22.803 -59.172 3.044 1.00 25.12 ? 157 ASP A C 1 ATOM 1062 O O . ASP A 1 137 ? 21.665 -59.579 3.146 1.00 25.06 ? 157 ASP A O 1 ATOM 1063 C CB . ASP A 1 137 ? 23.196 -57.508 4.777 1.00 30.00 ? 157 ASP A CB 1 ATOM 1064 C CG . ASP A 1 137 ? 23.663 -56.135 5.101 1.00 33.23 ? 157 ASP A CG 1 ATOM 1065 O OD1 . ASP A 1 137 ? 24.232 -55.446 4.235 1.00 33.63 ? 157 ASP A OD1 1 ATOM 1066 O OD2 . ASP A 1 137 ? 23.455 -55.713 6.237 1.00 44.71 ? 157 ASP A OD2 1 ATOM 1067 N N . VAL A 1 138 ? 23.848 -59.926 2.716 1.00 22.96 ? 158 VAL A N 1 ATOM 1068 C CA . VAL A 1 138 ? 23.750 -61.350 2.499 1.00 24.09 ? 158 VAL A CA 1 ATOM 1069 C C . VAL A 1 138 ? 24.961 -62.094 3.084 1.00 25.01 ? 158 VAL A C 1 ATOM 1070 O O . VAL A 1 138 ? 25.986 -61.503 3.379 1.00 25.19 ? 158 VAL A O 1 ATOM 1071 C CB . VAL A 1 138 ? 23.588 -61.685 1.000 1.00 25.55 ? 158 VAL A CB 1 ATOM 1072 C CG1 . VAL A 1 138 ? 22.439 -60.879 0.372 1.00 25.18 ? 158 VAL A CG1 1 ATOM 1073 C CG2 . VAL A 1 138 ? 24.875 -61.466 0.218 1.00 24.75 ? 158 VAL A CG2 1 ATOM 1074 N N . THR A 1 139 ? 24.811 -63.394 3.222 1.00 26.19 ? 159 THR A N 1 ATOM 1075 C CA . THR A 1 139 ? 25.896 -64.280 3.531 1.00 26.13 ? 159 THR A CA 1 ATOM 1076 C C . THR A 1 139 ? 26.196 -65.090 2.327 1.00 24.58 ? 159 THR A C 1 ATOM 1077 O O . THR A 1 139 ? 25.288 -65.661 1.701 1.00 25.51 ? 159 THR A O 1 ATOM 1078 C CB . THR A 1 139 ? 25.541 -65.239 4.690 1.00 29.00 ? 159 THR A CB 1 ATOM 1079 O OG1 . THR A 1 139 ? 25.162 -64.445 5.816 1.00 26.92 ? 159 THR A OG1 1 ATOM 1080 C CG2 . THR A 1 139 ? 26.774 -66.073 5.093 1.00 29.69 ? 159 THR A CG2 1 ATOM 1081 N N . TYR A 1 140 ? 27.490 -65.138 1.983 1.00 24.97 ? 160 TYR A N 1 ATOM 1082 C CA . TYR A 1 140 ? 27.952 -65.887 0.823 1.00 25.48 ? 160 TYR A CA 1 ATOM 1083 C C . TYR A 1 140 ? 29.164 -66.741 1.233 1.00 28.29 ? 160 TYR A C 1 ATOM 1084 O O . TYR A 1 140 ? 30.217 -66.187 1.579 1.00 25.17 ? 160 TYR A O 1 ATOM 1085 C CB . TYR A 1 140 ? 28.345 -64.957 -0.355 1.00 23.45 ? 160 TYR A CB 1 ATOM 1086 C CG . TYR A 1 140 ? 28.442 -65.753 -1.639 1.00 21.32 ? 160 TYR A CG 1 ATOM 1087 C CD1 . TYR A 1 140 ? 29.630 -66.370 -2.037 1.00 22.23 ? 160 TYR A CD1 1 ATOM 1088 C CD2 . TYR A 1 140 ? 27.321 -65.958 -2.422 1.00 20.87 ? 160 TYR A CD2 1 ATOM 1089 C CE1 . TYR A 1 140 ? 29.685 -67.142 -3.209 1.00 19.81 ? 160 TYR A CE1 1 ATOM 1090 C CE2 . TYR A 1 140 ? 27.367 -66.724 -3.585 1.00 19.61 ? 160 TYR A CE2 1 ATOM 1091 C CZ . TYR A 1 140 ? 28.553 -67.296 -3.978 1.00 20.10 ? 160 TYR A CZ 1 ATOM 1092 O OH . TYR A 1 140 ? 28.584 -68.049 -5.116 1.00 19.22 ? 160 TYR A OH 1 ATOM 1093 N N . ASP A 1 141 ? 28.972 -68.059 1.215 1.00 29.98 ? 161 ASP A N 1 ATOM 1094 C CA . ASP A 1 141 ? 29.966 -69.022 1.663 1.00 34.32 ? 161 ASP A CA 1 ATOM 1095 C C . ASP A 1 141 ? 30.557 -68.619 3.024 1.00 33.67 ? 161 ASP A C 1 ATOM 1096 O O . ASP A 1 141 ? 31.767 -68.543 3.208 1.00 31.84 ? 161 ASP A O 1 ATOM 1097 C CB . ASP A 1 141 ? 31.069 -69.122 0.603 1.00 38.15 ? 161 ASP A CB 1 ATOM 1098 C CG . ASP A 1 141 ? 31.999 -70.302 0.830 1.00 44.91 ? 161 ASP A CG 1 ATOM 1099 O OD1 . ASP A 1 141 ? 31.602 -71.268 1.514 1.00 43.23 ? 161 ASP A OD1 1 ATOM 1100 O OD2 . ASP A 1 141 ? 33.143 -70.244 0.344 1.00 47.38 ? 161 ASP A OD2 1 ATOM 1101 N N . GLY A 1 142 ? 29.687 -68.272 3.944 1.00 31.20 ? 162 GLY A N 1 ATOM 1102 C CA . GLY A 1 142 ? 30.098 -67.889 5.285 1.00 33.10 ? 162 GLY A CA 1 ATOM 1103 C C . GLY A 1 142 ? 30.510 -66.441 5.466 1.00 32.67 ? 162 GLY A C 1 ATOM 1104 O O . GLY A 1 142 ? 30.654 -66.023 6.583 1.00 38.63 ? 162 GLY A O 1 ATOM 1105 N N . GLU A 1 143 ? 30.730 -65.688 4.395 1.00 34.27 ? 163 GLU A N 1 ATOM 1106 C CA A GLU A 1 143 ? 31.180 -64.273 4.448 0.50 34.98 ? 163 GLU A CA 1 ATOM 1107 C CA B GLU A 1 143 ? 31.161 -64.299 4.508 0.50 36.55 ? 163 GLU A CA 1 ATOM 1108 C C . GLU A 1 143 ? 29.982 -63.312 4.384 1.00 34.62 ? 163 GLU A C 1 ATOM 1109 O O . GLU A 1 143 ? 29.041 -63.539 3.646 1.00 34.45 ? 163 GLU A O 1 ATOM 1110 C CB A GLU A 1 143 ? 32.172 -63.940 3.281 0.50 36.83 ? 163 GLU A CB 1 ATOM 1111 C CB B GLU A 1 143 ? 32.255 -64.029 3.480 0.50 41.13 ? 163 GLU A CB 1 ATOM 1112 C CG A GLU A 1 143 ? 32.813 -62.529 3.352 0.50 38.45 ? 163 GLU A CG 1 ATOM 1113 C CG B GLU A 1 143 ? 33.536 -64.826 3.785 0.50 45.97 ? 163 GLU A CG 1 ATOM 1114 C CD A GLU A 1 143 ? 33.508 -62.024 2.079 0.50 38.98 ? 163 GLU A CD 1 ATOM 1115 C CD B GLU A 1 143 ? 34.647 -64.641 2.758 0.50 47.13 ? 163 GLU A CD 1 ATOM 1116 O OE1 A GLU A 1 143 ? 32.944 -62.126 0.967 0.50 38.13 ? 163 GLU A OE1 1 ATOM 1117 O OE1 B GLU A 1 143 ? 34.783 -63.535 2.185 0.50 47.19 ? 163 GLU A OE1 1 ATOM 1118 O OE2 A GLU A 1 143 ? 34.618 -61.458 2.205 0.50 41.39 ? 163 GLU A OE2 1 ATOM 1119 O OE2 B GLU A 1 143 ? 35.386 -65.620 2.523 0.50 50.84 ? 163 GLU A OE2 1 ATOM 1120 N N . THR A 1 144 ? 30.026 -62.245 5.155 1.00 31.48 ? 164 THR A N 1 ATOM 1121 C CA . THR A 1 144 ? 29.025 -61.225 5.075 1.00 35.51 ? 164 THR A CA 1 ATOM 1122 C C . THR A 1 144 ? 29.393 -60.280 3.972 1.00 31.40 ? 164 THR A C 1 ATOM 1123 O O . THR A 1 144 ? 30.492 -59.782 3.950 1.00 33.20 ? 164 THR A O 1 ATOM 1124 C CB . THR A 1 144 ? 28.904 -60.400 6.377 1.00 38.77 ? 164 THR A CB 1 ATOM 1125 O OG1 . THR A 1 144 ? 28.467 -61.265 7.410 1.00 41.15 ? 164 THR A OG1 1 ATOM 1126 C CG2 . THR A 1 144 ? 27.808 -59.281 6.226 1.00 43.96 ? 164 THR A CG2 1 ATOM 1127 N N . THR A 1 145 ? 28.434 -59.983 3.109 1.00 30.21 ? 165 THR A N 1 ATOM 1128 C CA . THR A 1 145 ? 28.663 -59.056 1.975 1.00 26.59 ? 165 THR A CA 1 ATOM 1129 C C . THR A 1 145 ? 27.279 -58.491 1.586 1.00 27.15 ? 165 THR A C 1 ATOM 1130 O O . THR A 1 145 ? 26.382 -58.392 2.453 1.00 24.47 ? 165 THR A O 1 ATOM 1131 C CB . THR A 1 145 ? 29.465 -59.785 0.854 1.00 26.27 ? 165 THR A CB 1 ATOM 1132 O OG1 . THR A 1 145 ? 29.676 -58.926 -0.267 1.00 24.21 ? 165 THR A OG1 1 ATOM 1133 C CG2 . THR A 1 145 ? 28.796 -61.045 0.396 1.00 26.24 ? 165 THR A CG2 1 ATOM 1134 N N . ASN A 1 146 ? 27.091 -58.098 0.327 1.00 22.49 ? 166 ASN A N 1 ATOM 1135 C CA . ASN A 1 146 ? 25.773 -57.634 -0.093 1.00 21.03 ? 166 ASN A CA 1 ATOM 1136 C C . ASN A 1 146 ? 25.422 -58.204 -1.442 1.00 21.20 ? 166 ASN A C 1 ATOM 1137 O O . ASN A 1 146 ? 26.273 -58.779 -2.146 1.00 18.01 ? 166 ASN A O 1 ATOM 1138 C CB . ASN A 1 146 ? 25.700 -56.114 -0.074 1.00 20.03 ? 166 ASN A CB 1 ATOM 1139 C CG . ASN A 1 146 ? 26.638 -55.484 -1.102 1.00 21.49 ? 166 ASN A CG 1 ATOM 1140 O OD1 . ASN A 1 146 ? 26.352 -55.514 -2.305 1.00 18.71 ? 166 ASN A OD1 1 ATOM 1141 N ND2 . ASN A 1 146 ? 27.768 -54.919 -0.634 1.00 19.37 ? 166 ASN A ND2 1 ATOM 1142 N N . LEU A 1 147 ? 24.150 -58.053 -1.802 1.00 20.08 ? 167 LEU A N 1 ATOM 1143 C CA . LEU A 1 147 ? 23.617 -58.738 -2.976 1.00 18.44 ? 167 LEU A CA 1 ATOM 1144 C C . LEU A 1 147 ? 24.268 -58.206 -4.260 1.00 16.55 ? 167 LEU A C 1 ATOM 1145 O O . LEU A 1 147 ? 24.543 -58.972 -5.166 1.00 18.13 ? 167 LEU A O 1 ATOM 1146 C CB . LEU A 1 147 ? 22.070 -58.594 -3.032 1.00 18.00 ? 167 LEU A CB 1 ATOM 1147 C CG . LEU A 1 147 ? 21.371 -59.455 -4.092 1.00 18.83 ? 167 LEU A CG 1 ATOM 1148 C CD1 . LEU A 1 147 ? 21.513 -60.949 -3.864 1.00 19.30 ? 167 LEU A CD1 1 ATOM 1149 C CD2 . LEU A 1 147 ? 19.884 -59.114 -4.145 1.00 19.87 ? 167 LEU A CD2 1 ATOM 1150 N N . HIS A 1 148 ? 24.493 -56.909 -4.324 1.00 17.21 ? 168 HIS A N 1 ATOM 1151 C CA . HIS A 1 148 ? 25.122 -56.332 -5.484 1.00 19.09 ? 168 HIS A CA 1 ATOM 1152 C C . HIS A 1 148 ? 26.533 -56.964 -5.665 1.00 21.10 ? 168 HIS A C 1 ATOM 1153 O O . HIS A 1 148 ? 26.917 -57.382 -6.768 1.00 19.36 ? 168 HIS A O 1 ATOM 1154 C CB . HIS A 1 148 ? 25.272 -54.843 -5.340 1.00 18.94 ? 168 HIS A CB 1 ATOM 1155 C CG . HIS A 1 148 ? 25.797 -54.183 -6.574 1.00 20.48 ? 168 HIS A CG 1 ATOM 1156 N ND1 . HIS A 1 148 ? 24.981 -53.513 -7.465 1.00 21.53 ? 168 HIS A ND1 1 ATOM 1157 C CD2 . HIS A 1 148 ? 27.053 -54.134 -7.104 1.00 19.51 ? 168 HIS A CD2 1 ATOM 1158 C CE1 . HIS A 1 148 ? 25.716 -53.060 -8.477 1.00 20.22 ? 168 HIS A CE1 1 ATOM 1159 N NE2 . HIS A 1 148 ? 26.972 -53.391 -8.249 1.00 19.71 ? 168 HIS A NE2 1 ATOM 1160 N N . HIS A 1 149 ? 27.254 -57.055 -4.551 1.00 20.83 ? 169 HIS A N 1 ATOM 1161 C CA . HIS A 1 149 ? 28.625 -57.569 -4.573 1.00 20.62 ? 169 HIS A CA 1 ATOM 1162 C C . HIS A 1 149 ? 28.750 -58.995 -5.033 1.00 20.27 ? 169 HIS A C 1 ATOM 1163 O O . HIS A 1 149 ? 29.696 -59.353 -5.774 1.00 19.70 ? 169 HIS A O 1 ATOM 1164 C CB . HIS A 1 149 ? 29.286 -57.398 -3.210 1.00 22.35 ? 169 HIS A CB 1 ATOM 1165 C CG . HIS A 1 149 ? 30.778 -57.577 -3.240 1.00 24.88 ? 169 HIS A CG 1 ATOM 1166 N ND1 . HIS A 1 149 ? 31.397 -58.794 -3.016 1.00 28.68 ? 169 HIS A ND1 1 ATOM 1167 C CD2 . HIS A 1 149 ? 31.776 -56.691 -3.464 1.00 25.88 ? 169 HIS A CD2 1 ATOM 1168 C CE1 . HIS A 1 149 ? 32.708 -58.643 -3.081 1.00 23.91 ? 169 HIS A CE1 1 ATOM 1169 N NE2 . HIS A 1 149 ? 32.960 -57.381 -3.363 1.00 23.55 ? 169 HIS A NE2 1 ATOM 1170 N N . ILE A 1 150 ? 27.807 -59.831 -4.632 1.00 19.74 ? 170 ILE A N 1 ATOM 1171 C CA . ILE A 1 150 ? 27.861 -61.226 -5.094 1.00 20.08 ? 170 ILE A CA 1 ATOM 1172 C C . ILE A 1 150 ? 27.596 -61.361 -6.614 1.00 19.59 ? 170 ILE A C 1 ATOM 1173 O O . ILE A 1 150 ? 28.181 -62.225 -7.284 1.00 18.80 ? 170 ILE A O 1 ATOM 1174 C CB . ILE A 1 150 ? 27.023 -62.226 -4.234 1.00 20.76 ? 170 ILE A CB 1 ATOM 1175 C CG1 . ILE A 1 150 ? 25.513 -62.127 -4.489 1.00 20.83 ? 170 ILE A CG1 1 ATOM 1176 C CG2 . ILE A 1 150 ? 27.425 -62.084 -2.769 1.00 21.18 ? 170 ILE A CG2 1 ATOM 1177 C CD1 . ILE A 1 150 ? 24.788 -63.366 -3.961 1.00 21.96 ? 170 ILE A CD1 1 ATOM 1178 N N . TRP A 1 151 ? 26.696 -60.524 -7.142 1.00 19.21 ? 171 TRP A N 1 ATOM 1179 C CA . TRP A 1 151 ? 26.489 -60.491 -8.600 1.00 18.25 ? 171 TRP A CA 1 ATOM 1180 C C . TRP A 1 151 ? 27.732 -59.945 -9.360 1.00 17.30 ? 171 TRP A C 1 ATOM 1181 O O . TRP A 1 151 ? 28.098 -60.456 -10.400 1.00 15.80 ? 171 TRP A O 1 ATOM 1182 C CB . TRP A 1 151 ? 25.189 -59.754 -8.973 1.00 18.34 ? 171 TRP A CB 1 ATOM 1183 C CG . TRP A 1 151 ? 24.011 -60.676 -8.854 1.00 18.43 ? 171 TRP A CG 1 ATOM 1184 C CD1 . TRP A 1 151 ? 23.278 -60.938 -7.718 1.00 17.54 ? 171 TRP A CD1 1 ATOM 1185 C CD2 . TRP A 1 151 ? 23.483 -61.500 -9.873 1.00 18.88 ? 171 TRP A CD2 1 ATOM 1186 N NE1 . TRP A 1 151 ? 22.365 -61.885 -7.970 1.00 18.34 ? 171 TRP A NE1 1 ATOM 1187 C CE2 . TRP A 1 151 ? 22.432 -62.248 -9.293 1.00 19.88 ? 171 TRP A CE2 1 ATOM 1188 C CE3 . TRP A 1 151 ? 23.770 -61.661 -11.234 1.00 19.63 ? 171 TRP A CE3 1 ATOM 1189 C CZ2 . TRP A 1 151 ? 21.689 -63.180 -10.016 1.00 19.30 ? 171 TRP A CZ2 1 ATOM 1190 C CZ3 . TRP A 1 151 ? 23.004 -62.579 -11.967 1.00 20.36 ? 171 TRP A CZ3 1 ATOM 1191 C CH2 . TRP A 1 151 ? 21.992 -63.331 -11.348 1.00 20.78 ? 171 TRP A CH2 1 ATOM 1192 N N . ASP A 1 152 ? 28.367 -58.929 -8.793 1.00 18.64 ? 172 ASP A N 1 ATOM 1193 C CA . ASP A 1 152 ? 29.521 -58.296 -9.427 1.00 17.83 ? 172 ASP A CA 1 ATOM 1194 C C . ASP A 1 152 ? 30.746 -59.247 -9.418 1.00 18.85 ? 172 ASP A C 1 ATOM 1195 O O . ASP A 1 152 ? 31.446 -59.369 -10.422 1.00 16.14 ? 172 ASP A O 1 ATOM 1196 C CB . ASP A 1 152 ? 29.922 -56.995 -8.715 1.00 17.47 ? 172 ASP A CB 1 ATOM 1197 C CG . ASP A 1 152 ? 29.358 -55.727 -9.345 1.00 18.23 ? 172 ASP A CG 1 ATOM 1198 O OD1 . ASP A 1 152 ? 28.540 -55.733 -10.267 1.00 19.46 ? 172 ASP A OD1 1 ATOM 1199 O OD2 . ASP A 1 152 ? 29.722 -54.655 -8.825 1.00 20.23 ? 172 ASP A OD2 1 ATOM 1200 N N . THR A 1 153 ? 30.947 -59.938 -8.299 1.00 18.33 ? 173 THR A N 1 ATOM 1201 C CA . THR A 1 153 ? 32.263 -60.472 -7.916 1.00 18.94 ? 173 THR A CA 1 ATOM 1202 C C . THR A 1 153 ? 32.239 -61.911 -7.398 1.00 19.13 ? 173 THR A C 1 ATOM 1203 O O . THR A 1 153 ? 32.798 -62.806 -8.026 1.00 17.76 ? 173 THR A O 1 ATOM 1204 C CB . THR A 1 153 ? 32.919 -59.487 -6.934 1.00 19.28 ? 173 THR A CB 1 ATOM 1205 O OG1 . THR A 1 153 ? 33.089 -58.247 -7.637 1.00 20.04 ? 173 THR A OG1 1 ATOM 1206 C CG2 . THR A 1 153 ? 34.272 -59.973 -6.399 1.00 19.32 ? 173 THR A CG2 1 ATOM 1207 N N . ASN A 1 154 ? 31.581 -62.150 -6.279 1.00 20.80 ? 174 ASN A N 1 ATOM 1208 C CA . ASN A 1 154 ? 31.657 -63.473 -5.647 1.00 21.70 ? 174 ASN A CA 1 ATOM 1209 C C . ASN A 1 154 ? 31.252 -64.570 -6.586 1.00 21.99 ? 174 ASN A C 1 ATOM 1210 O O . ASN A 1 154 ? 31.972 -65.575 -6.756 1.00 24.30 ? 174 ASN A O 1 ATOM 1211 C CB . ASN A 1 154 ? 30.843 -63.536 -4.371 1.00 22.97 ? 174 ASN A CB 1 ATOM 1212 C CG . ASN A 1 154 ? 31.220 -62.456 -3.398 1.00 25.05 ? 174 ASN A CG 1 ATOM 1213 O OD1 . ASN A 1 154 ? 30.952 -61.264 -3.621 1.00 26.28 ? 174 ASN A OD1 1 ATOM 1214 N ND2 . ASN A 1 154 ? 31.810 -62.851 -2.284 1.00 26.78 ? 174 ASN A ND2 1 ATOM 1215 N N . MET A 1 155 ? 30.123 -64.401 -7.261 1.00 21.30 ? 175 MET A N 1 ATOM 1216 C CA . MET A 1 155 ? 29.600 -65.515 -8.066 1.00 22.15 ? 175 MET A CA 1 ATOM 1217 C C . MET A 1 155 ? 30.368 -65.702 -9.360 1.00 20.88 ? 175 MET A C 1 ATOM 1218 O O . MET A 1 155 ? 30.743 -66.816 -9.681 1.00 21.05 ? 175 MET A O 1 ATOM 1219 C CB . MET A 1 155 ? 28.071 -65.423 -8.282 1.00 22.35 ? 175 MET A CB 1 ATOM 1220 C CG . MET A 1 155 ? 27.279 -65.478 -6.978 1.00 22.41 ? 175 MET A CG 1 ATOM 1221 S SD . MET A 1 155 ? 25.483 -65.776 -7.203 1.00 22.20 ? 175 MET A SD 1 ATOM 1222 C CE . MET A 1 155 ? 25.063 -64.284 -8.107 1.00 22.36 ? 175 MET A CE 1 ATOM 1223 N N . PRO A 1 156 ? 30.621 -64.609 -10.116 1.00 20.16 ? 176 PRO A N 1 ATOM 1224 C CA . PRO A 1 156 ? 31.456 -64.803 -11.293 1.00 20.51 ? 176 PRO A CA 1 ATOM 1225 C C . PRO A 1 156 ? 32.876 -65.378 -11.025 1.00 19.72 ? 176 PRO A C 1 ATOM 1226 O O . PRO A 1 156 ? 33.331 -66.175 -11.800 1.00 19.46 ? 176 PRO A O 1 ATOM 1227 C CB . PRO A 1 156 ? 31.557 -63.380 -11.885 1.00 21.79 ? 176 PRO A CB 1 ATOM 1228 C CG . PRO A 1 156 ? 30.304 -62.703 -11.395 1.00 21.32 ? 176 PRO A CG 1 ATOM 1229 C CD . PRO A 1 156 ? 30.072 -63.248 -10.045 1.00 20.36 ? 176 PRO A CD 1 ATOM 1230 N N . GLU A 1 157 ? 33.544 -64.911 -9.967 1.00 19.97 ? 177 GLU A N 1 ATOM 1231 C CA . GLU A 1 157 ? 34.844 -65.449 -9.563 1.00 20.39 ? 177 GLU A CA 1 ATOM 1232 C C . GLU A 1 157 ? 34.733 -66.960 -9.231 1.00 21.44 ? 177 GLU A C 1 ATOM 1233 O O . GLU A 1 157 ? 35.559 -67.756 -9.655 1.00 20.50 ? 177 GLU A O 1 ATOM 1234 C CB . GLU A 1 157 ? 35.431 -64.682 -8.386 1.00 20.18 ? 177 GLU A CB 1 ATOM 1235 C CG . GLU A 1 157 ? 35.933 -63.348 -8.839 1.00 20.18 ? 177 GLU A CG 1 ATOM 1236 C CD . GLU A 1 157 ? 36.668 -62.543 -7.796 1.00 22.69 ? 177 GLU A CD 1 ATOM 1237 O OE1 . GLU A 1 157 ? 37.012 -61.386 -8.107 1.00 22.10 ? 177 GLU A OE1 1 ATOM 1238 O OE2 . GLU A 1 157 ? 36.919 -63.021 -6.677 1.00 22.07 ? 177 GLU A OE2 1 ATOM 1239 N N . GLU A 1 158 ? 33.692 -67.328 -8.499 1.00 22.00 ? 178 GLU A N 1 ATOM 1240 C CA . GLU A 1 158 ? 33.470 -68.723 -8.191 1.00 25.34 ? 178 GLU A CA 1 ATOM 1241 C C . GLU A 1 158 ? 33.311 -69.516 -9.489 1.00 27.62 ? 178 GLU A C 1 ATOM 1242 O O . GLU A 1 158 ? 33.939 -70.564 -9.654 1.00 29.73 ? 178 GLU A O 1 ATOM 1243 C CB . GLU A 1 158 ? 32.262 -68.934 -7.285 1.00 28.41 ? 178 GLU A CB 1 ATOM 1244 C CG . GLU A 1 158 ? 32.048 -70.415 -6.973 1.00 28.28 ? 178 GLU A CG 1 ATOM 1245 C CD . GLU A 1 158 ? 30.997 -70.683 -5.939 1.00 29.42 ? 178 GLU A CD 1 ATOM 1246 O OE1 . GLU A 1 158 ? 30.604 -71.886 -5.898 1.00 29.51 ? 178 GLU A OE1 1 ATOM 1247 O OE2 . GLU A 1 158 ? 30.606 -69.768 -5.149 1.00 27.22 ? 178 GLU A OE2 1 ATOM 1248 N N . ALA A 1 159 ? 32.513 -68.998 -10.421 1.00 23.70 ? 179 ALA A N 1 ATOM 1249 C CA . ALA A 1 159 ? 32.250 -69.707 -11.665 1.00 23.70 ? 179 ALA A CA 1 ATOM 1250 C C . ALA A 1 159 ? 33.509 -69.806 -12.517 1.00 24.35 ? 179 ALA A C 1 ATOM 1251 O O . ALA A 1 159 ? 33.751 -70.825 -13.150 1.00 22.26 ? 179 ALA A O 1 ATOM 1252 C CB . ALA A 1 159 ? 31.156 -69.025 -12.449 1.00 24.37 ? 179 ALA A CB 1 ATOM 1253 N N . ALA A 1 160 ? 34.262 -68.721 -12.578 1.00 23.87 ? 180 ALA A N 1 ATOM 1254 C CA . ALA A 1 160 ? 35.488 -68.687 -13.391 1.00 26.09 ? 180 ALA A CA 1 ATOM 1255 C C . ALA A 1 160 ? 36.661 -69.479 -12.755 1.00 26.28 ? 180 ALA A C 1 ATOM 1256 O O . ALA A 1 160 ? 37.610 -69.841 -13.440 1.00 26.05 ? 180 ALA A O 1 ATOM 1257 C CB . ALA A 1 160 ? 35.911 -67.259 -13.670 1.00 24.98 ? 180 ALA A CB 1 ATOM 1258 N N . GLY A 1 161 ? 36.580 -69.706 -11.455 1.00 29.39 ? 181 GLY A N 1 ATOM 1259 C CA . GLY A 1 161 ? 37.656 -70.338 -10.685 1.00 31.10 ? 181 GLY A CA 1 ATOM 1260 C C . GLY A 1 161 ? 38.845 -69.416 -10.387 1.00 32.25 ? 181 GLY A C 1 ATOM 1261 O O . GLY A 1 161 ? 39.968 -69.861 -10.313 1.00 32.96 ? 181 GLY A O 1 ATOM 1262 N N . GLY A 1 162 ? 38.589 -68.136 -10.199 1.00 29.72 ? 182 GLY A N 1 ATOM 1263 C CA . GLY A 1 162 ? 39.629 -67.182 -9.882 1.00 29.25 ? 182 GLY A CA 1 ATOM 1264 C C . GLY A 1 162 ? 39.229 -65.783 -10.293 1.00 30.93 ? 182 GLY A C 1 ATOM 1265 O O . GLY A 1 162 ? 38.048 -65.491 -10.549 1.00 28.02 ? 182 GLY A O 1 ATOM 1266 N N . TYR A 1 163 ? 40.220 -64.910 -10.282 1.00 29.48 ? 183 TYR A N 1 ATOM 1267 C CA . TYR A 1 163 ? 39.998 -63.467 -10.480 1.00 32.45 ? 183 TYR A CA 1 ATOM 1268 C C . TYR A 1 163 ? 41.035 -62.743 -11.309 1.00 28.24 ? 183 TYR A C 1 ATOM 1269 O O . TYR A 1 163 ? 40.843 -61.592 -11.618 1.00 31.14 ? 183 TYR A O 1 ATOM 1270 C CB . TYR A 1 163 ? 39.800 -62.732 -9.137 1.00 35.74 ? 183 TYR A CB 1 ATOM 1271 C CG . TYR A 1 163 ? 40.947 -62.700 -8.212 1.00 41.16 ? 183 TYR A CG 1 ATOM 1272 C CD1 . TYR A 1 163 ? 41.143 -63.743 -7.305 1.00 45.27 ? 183 TYR A CD1 1 ATOM 1273 C CD2 . TYR A 1 163 ? 41.813 -61.604 -8.177 1.00 45.57 ? 183 TYR A CD2 1 ATOM 1274 C CE1 . TYR A 1 163 ? 42.184 -63.728 -6.401 1.00 53.34 ? 183 TYR A CE1 1 ATOM 1275 C CE2 . TYR A 1 163 ? 42.863 -61.574 -7.266 1.00 56.15 ? 183 TYR A CE2 1 ATOM 1276 C CZ . TYR A 1 163 ? 43.041 -62.636 -6.377 1.00 61.08 ? 183 TYR A CZ 1 ATOM 1277 O OH . TYR A 1 163 ? 44.088 -62.633 -5.461 1.00 79.67 ? 183 TYR A OH 1 ATOM 1278 N N . SER A 1 164 ? 42.104 -63.425 -11.678 1.00 28.06 ? 184 SER A N 1 ATOM 1279 C CA . SER A 1 164 ? 43.229 -62.809 -12.344 1.00 27.65 ? 184 SER A CA 1 ATOM 1280 C C . SER A 1 164 ? 42.862 -62.597 -13.789 1.00 28.31 ? 184 SER A C 1 ATOM 1281 O O . SER A 1 164 ? 41.886 -63.160 -14.312 1.00 27.16 ? 184 SER A O 1 ATOM 1282 C CB . SER A 1 164 ? 44.461 -63.739 -12.302 1.00 28.96 ? 184 SER A CB 1 ATOM 1283 O OG . SER A 1 164 ? 44.243 -64.924 -13.055 1.00 27.27 ? 184 SER A OG 1 ATOM 1284 N N . LEU A 1 165 ? 43.676 -61.805 -14.445 1.00 25.98 ? 185 LEU A N 1 ATOM 1285 C CA . LEU A 1 165 ? 43.497 -61.541 -15.831 1.00 28.50 ? 185 LEU A CA 1 ATOM 1286 C C . LEU A 1 165 ? 43.571 -62.819 -16.701 1.00 29.42 ? 185 LEU A C 1 ATOM 1287 O O . LEU A 1 165 ? 42.781 -62.981 -17.665 1.00 26.90 ? 185 LEU A O 1 ATOM 1288 C CB . LEU A 1 165 ? 44.539 -60.539 -16.240 1.00 31.57 ? 185 LEU A CB 1 ATOM 1289 C CG . LEU A 1 165 ? 44.394 -59.961 -17.624 1.00 34.41 ? 185 LEU A CG 1 ATOM 1290 C CD1 . LEU A 1 165 ? 43.172 -59.031 -17.761 1.00 32.37 ? 185 LEU A CD1 1 ATOM 1291 C CD2 . LEU A 1 165 ? 45.702 -59.252 -17.969 1.00 36.17 ? 185 LEU A CD2 1 ATOM 1292 N N . SER A 1 166 ? 44.445 -63.751 -16.325 1.00 26.21 ? 186 SER A N 1 ATOM 1293 C CA . SER A 1 166 ? 44.592 -64.972 -17.103 1.00 29.15 ? 186 SER A CA 1 ATOM 1294 C C . SER A 1 166 ? 43.377 -65.923 -16.896 1.00 25.58 ? 186 SER A C 1 ATOM 1295 O O . SER A 1 166 ? 42.950 -66.595 -17.807 1.00 22.27 ? 186 SER A O 1 ATOM 1296 C CB . SER A 1 166 ? 45.933 -65.682 -16.822 1.00 29.50 ? 186 SER A CB 1 ATOM 1297 O OG . SER A 1 166 ? 45.940 -66.163 -15.498 1.00 36.74 ? 186 SER A OG 1 ATOM 1298 N N . VAL A 1 167 ? 42.833 -65.938 -15.698 1.00 24.55 ? 187 VAL A N 1 ATOM 1299 C CA . VAL A 1 167 ? 41.555 -66.628 -15.457 1.00 26.77 ? 187 VAL A CA 1 ATOM 1300 C C . VAL A 1 167 ? 40.414 -66.013 -16.310 1.00 23.40 ? 187 VAL A C 1 ATOM 1301 O O . VAL A 1 167 ? 39.598 -66.749 -16.857 1.00 23.89 ? 187 VAL A O 1 ATOM 1302 C CB . VAL A 1 167 ? 41.198 -66.650 -13.946 1.00 28.41 ? 187 VAL A CB 1 ATOM 1303 C CG1 . VAL A 1 167 ? 39.743 -67.139 -13.694 1.00 30.07 ? 187 VAL A CG1 1 ATOM 1304 C CG2 . VAL A 1 167 ? 42.189 -67.561 -13.230 1.00 28.19 ? 187 VAL A CG2 1 ATOM 1305 N N . ALA A 1 168 ? 40.389 -64.681 -16.393 1.00 21.80 ? 188 ALA A N 1 ATOM 1306 C CA . ALA A 1 168 ? 39.409 -63.941 -17.184 1.00 20.94 ? 188 ALA A CA 1 ATOM 1307 C C . ALA A 1 168 ? 39.500 -64.353 -18.649 1.00 22.51 ? 188 ALA A C 1 ATOM 1308 O O . ALA A 1 168 ? 38.474 -64.566 -19.318 1.00 20.35 ? 188 ALA A O 1 ATOM 1309 C CB . ALA A 1 168 ? 39.583 -62.446 -17.048 1.00 19.63 ? 188 ALA A CB 1 ATOM 1310 N N . LYS A 1 169 ? 40.726 -64.515 -19.118 1.00 21.58 ? 189 LYS A N 1 ATOM 1311 C CA . LYS A 1 169 ? 40.942 -64.878 -20.515 1.00 24.02 ? 189 LYS A CA 1 ATOM 1312 C C . LYS A 1 169 ? 40.433 -66.283 -20.775 1.00 21.33 ? 189 LYS A C 1 ATOM 1313 O O . LYS A 1 169 ? 39.745 -66.525 -21.780 1.00 21.07 ? 189 LYS A O 1 ATOM 1314 C CB . LYS A 1 169 ? 42.431 -64.748 -20.899 1.00 26.17 ? 189 LYS A CB 1 ATOM 1315 C CG . LYS A 1 169 ? 42.760 -65.308 -22.272 1.00 29.44 ? 189 LYS A CG 1 ATOM 1316 C CD . LYS A 1 169 ? 41.942 -64.689 -23.397 1.00 33.70 ? 189 LYS A CD 1 ATOM 1317 C CE . LYS A 1 169 ? 42.500 -65.157 -24.738 1.00 36.17 ? 189 LYS A CE 1 ATOM 1318 N NZ . LYS A 1 169 ? 41.609 -64.931 -25.908 1.00 37.20 ? 189 LYS A NZ 1 ATOM 1319 N N . THR A 1 170 ? 40.686 -67.195 -19.846 1.00 22.64 ? 190 THR A N 1 ATOM 1320 C CA . THR A 1 170 ? 40.178 -68.574 -19.993 1.00 24.85 ? 190 THR A CA 1 ATOM 1321 C C . THR A 1 170 ? 38.612 -68.626 -19.932 1.00 25.30 ? 190 THR A C 1 ATOM 1322 O O . THR A 1 170 ? 37.981 -69.393 -20.637 1.00 24.36 ? 190 THR A O 1 ATOM 1323 C CB . THR A 1 170 ? 40.747 -69.488 -18.898 1.00 27.89 ? 190 THR A CB 1 ATOM 1324 O OG1 . THR A 1 170 ? 42.169 -69.563 -19.034 1.00 29.45 ? 190 THR A OG1 1 ATOM 1325 C CG2 . THR A 1 170 ? 40.148 -70.908 -18.957 1.00 29.62 ? 190 THR A CG2 1 ATOM 1326 N N . TYR A 1 171 ? 38.025 -67.823 -19.053 1.00 21.83 ? 191 TYR A N 1 ATOM 1327 C CA . TYR A 1 171 ? 36.558 -67.748 -18.935 1.00 22.85 ? 191 TYR A CA 1 ATOM 1328 C C . TYR A 1 171 ? 35.965 -67.160 -20.204 1.00 21.08 ? 191 TYR A C 1 ATOM 1329 O O . TYR A 1 171 ? 34.993 -67.684 -20.733 1.00 19.98 ? 191 TYR A O 1 ATOM 1330 C CB . TYR A 1 171 ? 36.181 -66.901 -17.719 1.00 21.85 ? 191 TYR A CB 1 ATOM 1331 C CG . TYR A 1 171 ? 34.805 -67.024 -17.138 1.00 23.70 ? 191 TYR A CG 1 ATOM 1332 C CD1 . TYR A 1 171 ? 34.170 -68.265 -16.992 1.00 24.53 ? 191 TYR A CD1 1 ATOM 1333 C CD2 . TYR A 1 171 ? 34.160 -65.897 -16.600 1.00 21.56 ? 191 TYR A CD2 1 ATOM 1334 C CE1 . TYR A 1 171 ? 32.935 -68.365 -16.362 1.00 22.56 ? 191 TYR A CE1 1 ATOM 1335 C CE2 . TYR A 1 171 ? 32.936 -66.010 -15.938 1.00 23.00 ? 191 TYR A CE2 1 ATOM 1336 C CZ . TYR A 1 171 ? 32.314 -67.235 -15.856 1.00 21.86 ? 191 TYR A CZ 1 ATOM 1337 O OH . TYR A 1 171 ? 31.102 -67.354 -15.221 1.00 24.41 ? 191 TYR A OH 1 ATOM 1338 N N . ALA A 1 172 ? 36.577 -66.093 -20.702 1.00 20.35 ? 192 ALA A N 1 ATOM 1339 C CA . ALA A 1 172 ? 36.186 -65.487 -21.958 1.00 21.23 ? 192 ALA A CA 1 ATOM 1340 C C . ALA A 1 172 ? 36.179 -66.507 -23.111 1.00 24.79 ? 192 ALA A C 1 ATOM 1341 O O . ALA A 1 172 ? 35.232 -66.553 -23.891 1.00 21.56 ? 192 ALA A O 1 ATOM 1342 C CB . ALA A 1 172 ? 37.077 -64.330 -22.308 1.00 20.94 ? 192 ALA A CB 1 ATOM 1343 N N . ASP A 1 173 ? 37.240 -67.302 -23.204 1.00 25.22 ? 193 ASP A N 1 ATOM 1344 C CA . ASP A 1 173 ? 37.359 -68.270 -24.287 1.00 25.05 ? 193 ASP A CA 1 ATOM 1345 C C . ASP A 1 173 ? 36.295 -69.381 -24.162 1.00 24.11 ? 193 ASP A C 1 ATOM 1346 O O . ASP A 1 173 ? 35.730 -69.794 -25.157 1.00 23.38 ? 193 ASP A O 1 ATOM 1347 C CB . ASP A 1 173 ? 38.769 -68.875 -24.320 1.00 26.50 ? 193 ASP A CB 1 ATOM 1348 C CG . ASP A 1 173 ? 39.803 -67.911 -24.859 1.00 28.99 ? 193 ASP A CG 1 ATOM 1349 O OD1 . ASP A 1 173 ? 39.463 -66.894 -25.527 1.00 31.43 ? 193 ASP A OD1 1 ATOM 1350 O OD2 . ASP A 1 173 ? 40.986 -68.163 -24.625 1.00 33.79 ? 193 ASP A OD2 1 ATOM 1351 N N . LEU A 1 174 ? 36.001 -69.812 -22.944 1.00 24.07 ? 194 LEU A N 1 ATOM 1352 C CA . LEU A 1 174 ? 34.880 -70.711 -22.718 1.00 27.65 ? 194 LEU A CA 1 ATOM 1353 C C . LEU A 1 174 ? 33.549 -70.144 -23.279 1.00 29.38 ? 194 LEU A C 1 ATOM 1354 O O . LEU A 1 174 ? 32.826 -70.807 -24.068 1.00 28.91 ? 194 LEU A O 1 ATOM 1355 C CB . LEU A 1 174 ? 34.731 -70.991 -21.235 1.00 28.93 ? 194 LEU A CB 1 ATOM 1356 C CG . LEU A 1 174 ? 33.561 -71.897 -20.842 1.00 32.46 ? 194 LEU A CG 1 ATOM 1357 C CD1 . LEU A 1 174 ? 33.884 -73.334 -21.182 1.00 36.67 ? 194 LEU A CD1 1 ATOM 1358 C CD2 . LEU A 1 174 ? 33.226 -71.779 -19.377 1.00 33.82 ? 194 LEU A CD2 1 ATOM 1359 N N . LEU A 1 175 ? 33.232 -68.909 -22.886 1.00 27.14 ? 195 LEU A N 1 ATOM 1360 C CA . LEU A 1 175 ? 31.975 -68.261 -23.278 1.00 25.64 ? 195 LEU A CA 1 ATOM 1361 C C . LEU A 1 175 ? 31.967 -67.961 -24.762 1.00 25.05 ? 195 LEU A C 1 ATOM 1362 O O . LEU A 1 175 ? 30.933 -68.055 -25.436 1.00 24.37 ? 195 LEU A O 1 ATOM 1363 C CB . LEU A 1 175 ? 31.719 -66.983 -22.441 1.00 24.94 ? 195 LEU A CB 1 ATOM 1364 C CG . LEU A 1 175 ? 31.616 -67.282 -20.936 1.00 25.62 ? 195 LEU A CG 1 ATOM 1365 C CD1 . LEU A 1 175 ? 31.382 -65.994 -20.153 1.00 26.54 ? 195 LEU A CD1 1 ATOM 1366 C CD2 . LEU A 1 175 ? 30.506 -68.304 -20.602 1.00 25.90 ? 195 LEU A CD2 1 ATOM 1367 N N . THR A 1 176 ? 33.135 -67.613 -25.289 1.00 25.62 ? 196 THR A N 1 ATOM 1368 C CA . THR A 1 176 ? 33.261 -67.324 -26.733 1.00 26.49 ? 196 THR A CA 1 ATOM 1369 C C . THR A 1 176 ? 32.913 -68.560 -27.595 1.00 28.08 ? 196 THR A C 1 ATOM 1370 O O . THR A 1 176 ? 32.257 -68.450 -28.649 1.00 25.92 ? 196 THR A O 1 ATOM 1371 C CB . THR A 1 176 ? 34.658 -66.771 -27.048 1.00 26.14 ? 196 THR A CB 1 ATOM 1372 O OG1 . THR A 1 176 ? 34.720 -65.407 -26.591 1.00 25.20 ? 196 THR A OG1 1 ATOM 1373 C CG2 . THR A 1 176 ? 34.972 -66.810 -28.559 1.00 26.09 ? 196 THR A CG2 1 ATOM 1374 N N . GLU A 1 177 ? 33.375 -69.718 -27.145 1.00 31.95 ? 197 GLU A N 1 ATOM 1375 C CA . GLU A 1 177 ? 33.088 -70.974 -27.820 1.00 35.12 ? 197 GLU A CA 1 ATOM 1376 C C . GLU A 1 177 ? 31.580 -71.311 -27.731 1.00 30.85 ? 197 GLU A C 1 ATOM 1377 O O . GLU A 1 177 ? 30.996 -71.807 -28.687 1.00 31.06 ? 197 GLU A O 1 ATOM 1378 C CB . GLU A 1 177 ? 33.945 -72.120 -27.236 1.00 41.16 ? 197 GLU A CB 1 ATOM 1379 C CG . GLU A 1 177 ? 34.013 -73.344 -28.159 1.00 50.05 ? 197 GLU A CG 1 ATOM 1380 C CD . GLU A 1 177 ? 34.729 -73.018 -29.497 1.00 58.59 ? 197 GLU A CD 1 ATOM 1381 O OE1 . GLU A 1 177 ? 35.960 -72.786 -29.476 1.00 63.41 ? 197 GLU A OE1 1 ATOM 1382 O OE2 . GLU A 1 177 ? 34.051 -72.934 -30.563 1.00 56.12 ? 197 GLU A OE2 1 ATOM 1383 N N . ARG A 1 178 ? 30.969 -71.015 -26.600 1.00 25.57 ? 198 ARG A N 1 ATOM 1384 C CA . ARG A 1 178 ? 29.532 -71.144 -26.483 1.00 27.48 ? 198 ARG A CA 1 ATOM 1385 C C . ARG A 1 178 ? 28.774 -70.327 -27.530 1.00 28.95 ? 198 ARG A C 1 ATOM 1386 O O . ARG A 1 178 ? 27.785 -70.810 -28.096 1.00 28.82 ? 198 ARG A O 1 ATOM 1387 C CB . ARG A 1 178 ? 29.049 -70.776 -25.109 1.00 27.56 ? 198 ARG A CB 1 ATOM 1388 C CG . ARG A 1 178 ? 29.432 -71.791 -24.056 1.00 28.36 ? 198 ARG A CG 1 ATOM 1389 C CD . ARG A 1 178 ? 28.773 -71.404 -22.780 1.00 27.72 ? 198 ARG A CD 1 ATOM 1390 N NE . ARG A 1 178 ? 29.252 -72.180 -21.673 1.00 27.98 ? 198 ARG A NE 1 ATOM 1391 C CZ . ARG A 1 178 ? 29.048 -71.885 -20.400 1.00 28.59 ? 198 ARG A CZ 1 ATOM 1392 N NH1 . ARG A 1 178 ? 28.358 -70.814 -20.034 1.00 28.29 ? 198 ARG A NH1 1 ATOM 1393 N NH2 . ARG A 1 178 ? 29.537 -72.697 -19.475 1.00 32.56 ? 198 ARG A NH2 1 ATOM 1394 N N . ILE A 1 179 ? 29.265 -69.123 -27.815 1.00 26.42 ? 199 ILE A N 1 ATOM 1395 C CA . ILE A 1 179 ? 28.694 -68.285 -28.854 1.00 26.61 ? 199 ILE A CA 1 ATOM 1396 C C . ILE A 1 179 ? 28.934 -68.844 -30.280 1.00 30.22 ? 199 ILE A C 1 ATOM 1397 O O . ILE A 1 179 ? 28.025 -68.882 -31.115 1.00 28.34 ? 199 ILE A O 1 ATOM 1398 C CB . ILE A 1 179 ? 29.251 -66.843 -28.782 1.00 25.95 ? 199 ILE A CB 1 ATOM 1399 C CG1 . ILE A 1 179 ? 28.865 -66.146 -27.485 1.00 25.01 ? 199 ILE A CG1 1 ATOM 1400 C CG2 . ILE A 1 179 ? 28.780 -66.002 -29.967 1.00 26.06 ? 199 ILE A CG2 1 ATOM 1401 C CD1 . ILE A 1 179 ? 29.663 -64.870 -27.252 1.00 25.60 ? 199 ILE A CD1 1 ATOM 1402 N N . LYS A 1 180 ? 30.158 -69.217 -30.575 1.00 30.11 ? 200 LYS A N 1 ATOM 1403 C CA . LYS A 1 180 ? 30.498 -69.642 -31.953 1.00 34.25 ? 200 LYS A CA 1 ATOM 1404 C C . LYS A 1 180 ? 29.888 -70.988 -32.338 1.00 34.48 ? 200 LYS A C 1 ATOM 1405 O O . LYS A 1 180 ? 29.279 -71.096 -33.372 1.00 35.60 ? 200 LYS A O 1 ATOM 1406 C CB . LYS A 1 180 ? 32.008 -69.711 -32.127 1.00 35.92 ? 200 LYS A CB 1 ATOM 1407 C CG . LYS A 1 180 ? 32.639 -68.343 -32.004 1.00 39.29 ? 200 LYS A CG 1 ATOM 1408 C CD . LYS A 1 180 ? 34.156 -68.404 -32.071 1.00 44.01 ? 200 LYS A CD 1 ATOM 1409 C CE . LYS A 1 180 ? 34.745 -67.082 -32.555 1.00 48.93 ? 200 LYS A CE 1 ATOM 1410 N NZ . LYS A 1 180 ? 36.217 -67.060 -32.410 1.00 51.65 ? 200 LYS A NZ 1 ATOM 1411 N N . THR A 1 181 ? 29.999 -71.983 -31.462 1.00 34.89 ? 201 THR A N 1 ATOM 1412 C CA . THR A 1 181 ? 29.556 -73.350 -31.787 1.00 36.01 ? 201 THR A CA 1 ATOM 1413 C C . THR A 1 181 ? 28.733 -74.062 -30.727 1.00 38.20 ? 201 THR A C 1 ATOM 1414 O O . THR A 1 181 ? 28.212 -75.129 -31.006 1.00 43.96 ? 201 THR A O 1 ATOM 1415 C CB . THR A 1 181 ? 30.783 -74.250 -32.050 1.00 36.84 ? 201 THR A CB 1 ATOM 1416 O OG1 . THR A 1 181 ? 31.583 -74.328 -30.861 1.00 36.15 ? 201 THR A OG1 1 ATOM 1417 C CG2 . THR A 1 181 ? 31.635 -73.703 -33.170 1.00 36.91 ? 201 THR A CG2 1 ATOM 1418 N N . GLY A 1 182 ? 28.584 -73.501 -29.530 1.00 35.18 ? 202 GLY A N 1 ATOM 1419 C CA . GLY A 1 182 ? 27.949 -74.210 -28.406 1.00 33.97 ? 202 GLY A CA 1 ATOM 1420 C C . GLY A 1 182 ? 26.544 -73.732 -28.081 1.00 31.33 ? 202 GLY A C 1 ATOM 1421 O O . GLY A 1 182 ? 25.811 -73.321 -28.951 1.00 30.70 ? 202 GLY A O 1 ATOM 1422 N N . THR A 1 183 ? 26.214 -73.726 -26.808 1.00 31.85 ? 203 THR A N 1 ATOM 1423 C CA . THR A 1 183 ? 24.857 -73.424 -26.348 1.00 36.43 ? 203 THR A CA 1 ATOM 1424 C C . THR A 1 183 ? 24.273 -72.034 -26.639 1.00 33.83 ? 203 THR A C 1 ATOM 1425 O O . THR A 1 183 ? 23.056 -71.880 -26.574 1.00 32.49 ? 203 THR A O 1 ATOM 1426 C CB . THR A 1 183 ? 24.726 -73.696 -24.829 1.00 41.48 ? 203 THR A CB 1 ATOM 1427 O OG1 . THR A 1 183 ? 25.815 -73.070 -24.133 1.00 39.99 ? 203 THR A OG1 1 ATOM 1428 C CG2 . THR A 1 183 ? 24.768 -75.221 -24.572 1.00 43.94 ? 203 THR A CG2 1 ATOM 1429 N N . TYR A 1 184 ? 25.106 -71.046 -26.964 1.00 31.30 ? 204 TYR A N 1 ATOM 1430 C CA . TYR A 1 184 ? 24.609 -69.725 -27.349 1.00 30.41 ? 204 TYR A CA 1 ATOM 1431 C C . TYR A 1 184 ? 24.538 -69.519 -28.856 1.00 30.80 ? 204 TYR A C 1 ATOM 1432 O O . TYR A 1 184 ? 24.040 -68.475 -29.276 1.00 30.72 ? 204 TYR A O 1 ATOM 1433 C CB . TYR A 1 184 ? 25.444 -68.558 -26.721 1.00 26.78 ? 204 TYR A CB 1 ATOM 1434 C CG . TYR A 1 184 ? 25.693 -68.666 -25.264 1.00 24.09 ? 204 TYR A CG 1 ATOM 1435 C CD1 . TYR A 1 184 ? 24.732 -69.231 -24.395 1.00 25.45 ? 204 TYR A CD1 1 ATOM 1436 C CD2 . TYR A 1 184 ? 26.849 -68.124 -24.695 1.00 22.10 ? 204 TYR A CD2 1 ATOM 1437 C CE1 . TYR A 1 184 ? 24.963 -69.329 -23.022 1.00 24.70 ? 204 TYR A CE1 1 ATOM 1438 C CE2 . TYR A 1 184 ? 27.074 -68.207 -23.320 1.00 23.34 ? 204 TYR A CE2 1 ATOM 1439 C CZ . TYR A 1 184 ? 26.143 -68.795 -22.487 1.00 23.11 ? 204 TYR A CZ 1 ATOM 1440 O OH . TYR A 1 184 ? 26.368 -68.918 -21.130 1.00 23.45 ? 204 TYR A OH 1 ATOM 1441 N N . SER A 1 185 ? 25.016 -70.473 -29.666 1.00 31.52 ? 205 SER A N 1 ATOM 1442 C CA . SER A 1 185 ? 25.128 -70.214 -31.129 1.00 36.35 ? 205 SER A CA 1 ATOM 1443 C C . SER A 1 185 ? 23.798 -69.962 -31.840 1.00 37.07 ? 205 SER A C 1 ATOM 1444 O O . SER A 1 185 ? 23.749 -69.171 -32.751 1.00 39.73 ? 205 SER A O 1 ATOM 1445 C CB . SER A 1 185 ? 25.936 -71.245 -31.891 1.00 37.82 ? 205 SER A CB 1 ATOM 1446 O OG . SER A 1 185 ? 25.591 -72.542 -31.494 1.00 44.42 ? 205 SER A OG 1 ATOM 1447 N N A SER A 1 186 ? 22.726 -70.608 -31.392 0.50 36.92 ? 206 SER A N 1 ATOM 1448 N N B SER A 1 186 ? 22.741 -70.624 -31.389 0.50 36.82 ? 206 SER A N 1 ATOM 1449 C CA A SER A 1 186 ? 21.371 -70.354 -31.929 0.50 39.56 ? 206 SER A CA 1 ATOM 1450 C CA B SER A 1 186 ? 21.421 -70.308 -31.891 0.50 39.24 ? 206 SER A CA 1 ATOM 1451 C C A SER A 1 186 ? 20.649 -69.122 -31.327 0.50 37.50 ? 206 SER A C 1 ATOM 1452 C C B SER A 1 186 ? 21.224 -68.843 -31.555 0.50 35.60 ? 206 SER A C 1 ATOM 1453 O O A SER A 1 186 ? 19.538 -68.769 -31.784 0.50 40.49 ? 206 SER A O 1 ATOM 1454 O O B SER A 1 186 ? 21.301 -68.001 -32.462 0.50 32.70 ? 206 SER A O 1 ATOM 1455 C CB A SER A 1 186 ? 20.456 -71.586 -31.742 0.50 40.43 ? 206 SER A CB 1 ATOM 1456 C CB B SER A 1 186 ? 20.296 -71.200 -31.307 0.50 42.19 ? 206 SER A CB 1 ATOM 1457 O OG A SER A 1 186 ? 19.904 -71.650 -30.413 0.50 40.01 ? 206 SER A OG 1 ATOM 1458 O OG B SER A 1 186 ? 20.232 -71.212 -29.880 0.50 43.16 ? 206 SER A OG 1 ATOM 1459 N N . LYS A 1 187 ? 21.192 -68.564 -30.250 1.00 31.31 ? 207 LYS A N 1 ATOM 1460 C CA . LYS A 1 187 ? 20.714 -67.285 -29.697 1.00 30.73 ? 207 LYS A CA 1 ATOM 1461 C C . LYS A 1 187 ? 21.398 -66.013 -30.177 1.00 28.74 ? 207 LYS A C 1 ATOM 1462 O O . LYS A 1 187 ? 20.753 -64.943 -30.280 1.00 23.01 ? 207 LYS A O 1 ATOM 1463 C CB . LYS A 1 187 ? 20.821 -67.286 -28.188 1.00 31.95 ? 207 LYS A CB 1 ATOM 1464 C CG . LYS A 1 187 ? 20.160 -68.469 -27.564 1.00 30.98 ? 207 LYS A CG 1 ATOM 1465 C CD . LYS A 1 187 ? 20.612 -68.648 -26.141 1.00 31.45 ? 207 LYS A CD 1 ATOM 1466 C CE . LYS A 1 187 ? 19.557 -69.412 -25.389 1.00 31.35 ? 207 LYS A CE 1 ATOM 1467 N NZ . LYS A 1 187 ? 19.937 -69.522 -23.976 1.00 34.52 ? 207 LYS A NZ 1 ATOM 1468 N N . LYS A 1 188 ? 22.691 -66.129 -30.495 1.00 29.04 ? 208 LYS A N 1 ATOM 1469 C CA . LYS A 1 188 ? 23.504 -64.924 -30.813 1.00 28.20 ? 208 LYS A CA 1 ATOM 1470 C C . LYS A 1 188 ? 23.000 -64.056 -31.967 1.00 29.57 ? 208 LYS A C 1 ATOM 1471 O O . LYS A 1 188 ? 23.220 -62.846 -31.962 1.00 30.88 ? 208 LYS A O 1 ATOM 1472 C CB . LYS A 1 188 ? 24.978 -65.283 -31.038 1.00 34.81 ? 208 LYS A CB 1 ATOM 1473 C CG . LYS A 1 188 ? 25.235 -66.306 -32.145 1.00 36.74 ? 208 LYS A CG 1 ATOM 1474 C CD . LYS A 1 188 ? 26.299 -65.862 -33.128 1.00 40.44 ? 208 LYS A CD 1 ATOM 1475 C CE . LYS A 1 188 ? 26.390 -66.866 -34.283 1.00 40.07 ? 208 LYS A CE 1 ATOM 1476 N NZ . LYS A 1 188 ? 27.047 -68.120 -33.859 1.00 41.71 ? 208 LYS A NZ 1 ATOM 1477 N N . ASP A 1 189 ? 22.263 -64.616 -32.938 1.00 30.77 ? 209 ASP A N 1 ATOM 1478 C CA . ASP A 1 189 ? 21.707 -63.768 -34.041 1.00 33.02 ? 209 ASP A CA 1 ATOM 1479 C C . ASP A 1 189 ? 20.687 -62.721 -33.540 1.00 34.43 ? 209 ASP A C 1 ATOM 1480 O O . ASP A 1 189 ? 20.621 -61.549 -34.008 1.00 38.64 ? 209 ASP A O 1 ATOM 1481 C CB . ASP A 1 189 ? 21.123 -64.637 -35.146 1.00 41.39 ? 209 ASP A CB 1 ATOM 1482 C CG . ASP A 1 189 ? 22.128 -65.725 -35.640 1.00 50.42 ? 209 ASP A CG 1 ATOM 1483 O OD1 . ASP A 1 189 ? 23.346 -65.440 -35.706 1.00 54.34 ? 209 ASP A OD1 1 ATOM 1484 O OD2 . ASP A 1 189 ? 21.737 -66.882 -35.899 1.00 57.82 ? 209 ASP A OD2 1 ATOM 1485 N N . SER A 1 190 ? 19.995 -63.093 -32.473 1.00 29.15 ? 210 SER A N 1 ATOM 1486 C CA . SER A 1 190 ? 19.084 -62.155 -31.852 1.00 29.67 ? 210 SER A CA 1 ATOM 1487 C C . SER A 1 190 ? 19.801 -61.096 -30.984 1.00 24.13 ? 210 SER A C 1 ATOM 1488 O O . SER A 1 190 ? 19.175 -60.109 -30.597 1.00 22.50 ? 210 SER A O 1 ATOM 1489 C CB . SER A 1 190 ? 18.014 -62.895 -31.025 1.00 29.57 ? 210 SER A CB 1 ATOM 1490 O OG . SER A 1 190 ? 18.535 -63.419 -29.803 1.00 29.09 ? 210 SER A OG 1 ATOM 1491 N N . TRP A 1 191 ? 21.084 -61.311 -30.688 1.00 23.28 ? 211 TRP A N 1 ATOM 1492 C CA . TRP A 1 191 ? 21.807 -60.456 -29.688 1.00 22.14 ? 211 TRP A CA 1 ATOM 1493 C C . TRP A 1 191 ? 22.105 -59.041 -30.159 1.00 20.84 ? 211 TRP A C 1 ATOM 1494 O O . TRP A 1 191 ? 22.301 -58.134 -29.336 1.00 18.88 ? 211 TRP A O 1 ATOM 1495 C CB . TRP A 1 191 ? 23.081 -61.146 -29.188 1.00 22.74 ? 211 TRP A CB 1 ATOM 1496 C CG . TRP A 1 191 ? 22.801 -62.283 -28.322 1.00 23.29 ? 211 TRP A CG 1 ATOM 1497 C CD1 . TRP A 1 191 ? 21.534 -62.790 -27.969 1.00 25.16 ? 211 TRP A CD1 1 ATOM 1498 C CD2 . TRP A 1 191 ? 23.738 -63.094 -27.656 1.00 23.61 ? 211 TRP A CD2 1 ATOM 1499 N NE1 . TRP A 1 191 ? 21.665 -63.849 -27.150 1.00 25.20 ? 211 TRP A NE1 1 ATOM 1500 C CE2 . TRP A 1 191 ? 22.995 -64.058 -26.910 1.00 24.52 ? 211 TRP A CE2 1 ATOM 1501 C CE3 . TRP A 1 191 ? 25.144 -63.095 -27.569 1.00 22.20 ? 211 TRP A CE3 1 ATOM 1502 C CZ2 . TRP A 1 191 ? 23.610 -65.028 -26.107 1.00 23.96 ? 211 TRP A CZ2 1 ATOM 1503 C CZ3 . TRP A 1 191 ? 25.749 -64.058 -26.774 1.00 21.76 ? 211 TRP A CZ3 1 ATOM 1504 C CH2 . TRP A 1 191 ? 24.989 -65.021 -26.063 1.00 22.83 ? 211 TRP A CH2 1 ATOM 1505 N N . THR A 1 192 ? 22.089 -58.828 -31.461 1.00 19.84 ? 212 THR A N 1 ATOM 1506 C CA . THR A 1 192 ? 22.287 -57.499 -32.018 1.00 22.33 ? 212 THR A CA 1 ATOM 1507 C C . THR A 1 192 ? 21.029 -56.969 -32.659 1.00 23.38 ? 212 THR A C 1 ATOM 1508 O O . THR A 1 192 ? 21.064 -55.942 -33.293 1.00 21.05 ? 212 THR A O 1 ATOM 1509 C CB . THR A 1 192 ? 23.483 -57.450 -33.011 1.00 25.67 ? 212 THR A CB 1 ATOM 1510 O OG1 . THR A 1 192 ? 23.322 -58.468 -33.990 1.00 31.96 ? 212 THR A OG1 1 ATOM 1511 C CG2 . THR A 1 192 ? 24.781 -57.805 -32.264 1.00 26.02 ? 212 THR A CG2 1 ATOM 1512 N N . ASP A 1 193 ? 19.879 -57.595 -32.398 1.00 24.09 ? 213 ASP A N 1 ATOM 1513 C CA . ASP A 1 193 ? 18.604 -56.995 -32.847 1.00 25.32 ? 213 ASP A CA 1 ATOM 1514 C C . ASP A 1 193 ? 18.385 -55.548 -32.363 1.00 22.96 ? 213 ASP A C 1 ATOM 1515 O O . ASP A 1 193 ? 18.460 -55.241 -31.168 1.00 24.65 ? 213 ASP A O 1 ATOM 1516 C CB . ASP A 1 193 ? 17.397 -57.806 -32.362 1.00 27.12 ? 213 ASP A CB 1 ATOM 1517 C CG . ASP A 1 193 ? 17.205 -59.124 -33.074 1.00 29.33 ? 213 ASP A CG 1 ATOM 1518 O OD1 . ASP A 1 193 ? 17.875 -59.435 -34.078 1.00 29.80 ? 213 ASP A OD1 1 ATOM 1519 O OD2 . ASP A 1 193 ? 16.345 -59.880 -32.570 1.00 32.08 ? 213 ASP A OD2 1 ATOM 1520 N N . GLY A 1 194 ? 18.033 -54.686 -33.302 1.00 21.06 ? 214 GLY A N 1 ATOM 1521 C CA . GLY A 1 194 ? 17.806 -53.282 -33.014 1.00 21.21 ? 214 GLY A CA 1 ATOM 1522 C C . GLY A 1 194 ? 19.018 -52.377 -32.832 1.00 21.87 ? 214 GLY A C 1 ATOM 1523 O O . GLY A 1 194 ? 18.836 -51.218 -32.560 1.00 23.05 ? 214 GLY A O 1 ATOM 1524 N N . ILE A 1 195 ? 20.242 -52.897 -32.989 1.00 21.24 ? 215 ILE A N 1 ATOM 1525 C CA . ILE A 1 195 ? 21.415 -52.106 -32.791 1.00 21.94 ? 215 ILE A CA 1 ATOM 1526 C C . ILE A 1 195 ? 21.456 -50.971 -33.839 1.00 21.01 ? 215 ILE A C 1 ATOM 1527 O O . ILE A 1 195 ? 21.223 -51.206 -35.014 1.00 20.98 ? 215 ILE A O 1 ATOM 1528 C CB . ILE A 1 195 ? 22.655 -53.001 -32.853 1.00 25.03 ? 215 ILE A CB 1 ATOM 1529 C CG1 . ILE A 1 195 ? 23.893 -52.284 -32.400 1.00 25.66 ? 215 ILE A CG1 1 ATOM 1530 C CG2 . ILE A 1 195 ? 22.922 -53.568 -34.277 1.00 29.76 ? 215 ILE A CG2 1 ATOM 1531 C CD1 . ILE A 1 195 ? 24.999 -53.284 -32.087 1.00 31.26 ? 215 ILE A CD1 1 ATOM 1532 N N . ASP A 1 196 ? 21.692 -49.751 -33.391 1.00 17.87 ? 216 ASP A N 1 ATOM 1533 C CA . ASP A 1 196 ? 21.670 -48.597 -34.246 1.00 17.43 ? 216 ASP A CA 1 ATOM 1534 C C . ASP A 1 196 ? 22.715 -47.577 -33.697 1.00 18.04 ? 216 ASP A C 1 ATOM 1535 O O . ASP A 1 196 ? 22.469 -46.916 -32.710 1.00 16.30 ? 216 ASP A O 1 ATOM 1536 C CB . ASP A 1 196 ? 20.277 -47.970 -34.256 1.00 17.17 ? 216 ASP A CB 1 ATOM 1537 C CG . ASP A 1 196 ? 20.153 -46.757 -35.146 1.00 17.21 ? 216 ASP A CG 1 ATOM 1538 O OD1 . ASP A 1 196 ? 21.130 -46.357 -35.773 1.00 18.62 ? 216 ASP A OD1 1 ATOM 1539 O OD2 . ASP A 1 196 ? 19.042 -46.172 -35.241 1.00 17.84 ? 216 ASP A OD2 1 ATOM 1540 N N . ILE A 1 197 ? 23.807 -47.411 -34.465 1.00 17.07 ? 217 ILE A N 1 ATOM 1541 C CA . ILE A 1 197 ? 24.893 -46.491 -34.135 1.00 18.11 ? 217 ILE A CA 1 ATOM 1542 C C . ILE A 1 197 ? 24.403 -45.056 -34.041 1.00 17.72 ? 217 ILE A C 1 ATOM 1543 O O . ILE A 1 197 ? 24.998 -44.211 -33.309 1.00 15.68 ? 217 ILE A O 1 ATOM 1544 C CB . ILE A 1 197 ? 26.120 -46.650 -35.108 1.00 19.76 ? 217 ILE A CB 1 ATOM 1545 C CG1 . ILE A 1 197 ? 27.365 -45.972 -34.570 1.00 20.76 ? 217 ILE A CG1 1 ATOM 1546 C CG2 . ILE A 1 197 ? 25.813 -46.091 -36.517 1.00 19.33 ? 217 ILE A CG2 1 ATOM 1547 C CD1 . ILE A 1 197 ? 27.767 -46.359 -33.143 1.00 21.05 ? 217 ILE A CD1 1 ATOM 1548 N N . LYS A 1 198 ? 23.317 -44.751 -34.758 1.00 17.47 ? 218 LYS A N 1 ATOM 1549 C CA . LYS A 1 198 ? 22.786 -43.375 -34.734 1.00 17.66 ? 218 LYS A CA 1 ATOM 1550 C C . LYS A 1 198 ? 21.814 -43.152 -33.603 1.00 16.67 ? 218 LYS A C 1 ATOM 1551 O O . LYS A 1 198 ? 21.329 -42.074 -33.450 1.00 18.72 ? 218 LYS A O 1 ATOM 1552 C CB . LYS A 1 198 ? 22.124 -43.017 -36.061 1.00 20.13 ? 218 LYS A CB 1 ATOM 1553 C CG . LYS A 1 198 ? 23.078 -43.079 -37.236 1.00 20.35 ? 218 LYS A CG 1 ATOM 1554 C CD . LYS A 1 198 ? 22.242 -42.759 -38.472 1.00 22.64 ? 218 LYS A CD 1 ATOM 1555 C CE . LYS A 1 198 ? 22.943 -43.173 -39.752 1.00 23.93 ? 218 LYS A CE 1 ATOM 1556 N NZ . LYS A 1 198 ? 24.159 -42.358 -39.947 1.00 22.94 ? 218 LYS A NZ 1 ATOM 1557 N N . ASP A 1 199 ? 21.576 -44.157 -32.768 1.00 17.18 ? 219 ASP A N 1 ATOM 1558 C CA . ASP A 1 199 ? 20.639 -44.009 -31.680 1.00 17.32 ? 219 ASP A CA 1 ATOM 1559 C C . ASP A 1 199 ? 21.172 -44.802 -30.447 1.00 18.13 ? 219 ASP A C 1 ATOM 1560 O O . ASP A 1 199 ? 20.692 -45.888 -30.107 1.00 17.67 ? 219 ASP A O 1 ATOM 1561 C CB . ASP A 1 199 ? 19.235 -44.486 -32.139 1.00 16.74 ? 219 ASP A CB 1 ATOM 1562 C CG . ASP A 1 199 ? 18.120 -44.082 -31.158 1.00 16.91 ? 219 ASP A CG 1 ATOM 1563 O OD1 . ASP A 1 199 ? 18.431 -43.610 -30.015 1.00 16.81 ? 219 ASP A OD1 1 ATOM 1564 O OD2 . ASP A 1 199 ? 16.939 -44.325 -31.523 1.00 17.43 ? 219 ASP A OD2 1 ATOM 1565 N N . PRO A 1 200 ? 22.254 -44.284 -29.849 1.00 17.32 ? 220 PRO A N 1 ATOM 1566 C CA . PRO A 1 200 ? 22.846 -44.943 -28.680 1.00 17.67 ? 220 PRO A CA 1 ATOM 1567 C C . PRO A 1 200 ? 21.883 -45.114 -27.496 1.00 15.19 ? 220 PRO A C 1 ATOM 1568 O O . PRO A 1 200 ? 21.960 -46.118 -26.836 1.00 15.77 ? 220 PRO A O 1 ATOM 1569 C CB . PRO A 1 200 ? 24.007 -44.005 -28.276 1.00 17.77 ? 220 PRO A CB 1 ATOM 1570 C CG . PRO A 1 200 ? 24.256 -43.166 -29.480 1.00 19.41 ? 220 PRO A CG 1 ATOM 1571 C CD . PRO A 1 200 ? 22.966 -43.050 -30.230 1.00 18.31 ? 220 PRO A CD 1 ATOM 1572 N N . VAL A 1 201 ? 20.981 -44.172 -27.288 1.00 14.74 ? 221 VAL A N 1 ATOM 1573 C CA . VAL A 1 201 ? 19.985 -44.298 -26.221 1.00 15.90 ? 221 VAL A CA 1 ATOM 1574 C C . VAL A 1 201 ? 19.093 -45.515 -26.420 1.00 15.89 ? 221 VAL A C 1 ATOM 1575 O O . VAL A 1 201 ? 19.056 -46.398 -25.585 1.00 15.65 ? 221 VAL A O 1 ATOM 1576 C CB . VAL A 1 201 ? 19.162 -43.004 -26.067 1.00 16.87 ? 221 VAL A CB 1 ATOM 1577 C CG1 . VAL A 1 201 ? 18.015 -43.207 -25.083 1.00 18.68 ? 221 VAL A CG1 1 ATOM 1578 C CG2 . VAL A 1 201 ? 20.079 -41.918 -25.544 1.00 18.00 ? 221 VAL A CG2 1 ATOM 1579 N N . SER A 1 202 ? 18.451 -45.597 -27.595 1.00 16.93 ? 222 SER A N 1 ATOM 1580 C CA . SER A 1 202 ? 17.624 -46.772 -27.905 1.00 16.25 ? 222 SER A CA 1 ATOM 1581 C C . SER A 1 202 ? 18.426 -48.020 -27.832 1.00 16.14 ? 222 SER A C 1 ATOM 1582 O O . SER A 1 202 ? 17.942 -49.022 -27.283 1.00 19.08 ? 222 SER A O 1 ATOM 1583 C CB A SER A 1 202 ? 17.007 -46.682 -29.282 0.50 17.18 ? 222 SER A CB 1 ATOM 1584 C CB B SER A 1 202 ? 16.904 -46.647 -29.274 0.50 15.89 ? 222 SER A CB 1 ATOM 1585 O OG A SER A 1 202 ? 16.423 -47.915 -29.579 0.50 18.91 ? 222 SER A OG 1 ATOM 1586 O OG B SER A 1 202 ? 16.110 -45.465 -29.327 0.50 15.18 ? 222 SER A OG 1 ATOM 1587 N N . THR A 1 203 ? 19.628 -48.014 -28.419 1.00 15.59 ? 223 THR A N 1 ATOM 1588 C CA . THR A 1 203 ? 20.396 -49.234 -28.477 1.00 14.68 ? 223 THR A CA 1 ATOM 1589 C C . THR A 1 203 ? 20.748 -49.751 -27.056 1.00 14.92 ? 223 THR A C 1 ATOM 1590 O O . THR A 1 203 ? 20.553 -50.933 -26.735 1.00 14.11 ? 223 THR A O 1 ATOM 1591 C CB . THR A 1 203 ? 21.660 -49.086 -29.319 1.00 15.76 ? 223 THR A CB 1 ATOM 1592 O OG1 . THR A 1 203 ? 21.324 -48.742 -30.680 1.00 15.71 ? 223 THR A OG1 1 ATOM 1593 C CG2 . THR A 1 203 ? 22.456 -50.383 -29.254 1.00 15.24 ? 223 THR A CG2 1 ATOM 1594 N N . SER A 1 204 ? 21.296 -48.879 -26.229 1.00 14.48 ? 224 SER A N 1 ATOM 1595 C CA . SER A 1 204 ? 21.731 -49.301 -24.901 1.00 14.71 ? 224 SER A CA 1 ATOM 1596 C C . SER A 1 204 ? 20.522 -49.630 -23.999 1.00 14.83 ? 224 SER A C 1 ATOM 1597 O O . SER A 1 204 ? 20.635 -50.473 -23.100 1.00 14.67 ? 224 SER A O 1 ATOM 1598 C CB . SER A 1 204 ? 22.707 -48.275 -24.264 1.00 13.69 ? 224 SER A CB 1 ATOM 1599 O OG . SER A 1 204 ? 22.184 -46.990 -24.178 1.00 13.00 ? 224 SER A OG 1 ATOM 1600 N N . MET A 1 205 ? 19.396 -48.974 -24.264 1.00 15.47 ? 225 MET A N 1 ATOM 1601 C CA . MET A 1 205 ? 18.131 -49.296 -23.564 1.00 15.97 ? 225 MET A CA 1 ATOM 1602 C C . MET A 1 205 ? 17.649 -50.719 -23.831 1.00 16.05 ? 225 MET A C 1 ATOM 1603 O O . MET A 1 205 ? 17.153 -51.353 -22.922 1.00 13.92 ? 225 MET A O 1 ATOM 1604 C CB . MET A 1 205 ? 17.023 -48.280 -23.853 1.00 16.33 ? 225 MET A CB 1 ATOM 1605 C CG . MET A 1 205 ? 17.136 -46.979 -23.072 1.00 16.59 ? 225 MET A CG 1 ATOM 1606 S SD . MET A 1 205 ? 16.906 -47.214 -21.262 1.00 18.00 ? 225 MET A SD 1 ATOM 1607 C CE . MET A 1 205 ? 15.196 -47.783 -21.247 1.00 20.65 ? 225 MET A CE 1 ATOM 1608 N N . ILE A 1 206 ? 17.883 -51.248 -25.031 1.00 16.73 ? 226 ILE A N 1 ATOM 1609 C CA . ILE A 1 206 ? 17.573 -52.658 -25.303 1.00 17.75 ? 226 ILE A CA 1 ATOM 1610 C C . ILE A 1 206 ? 18.324 -53.545 -24.325 1.00 16.77 ? 226 ILE A C 1 ATOM 1611 O O . ILE A 1 206 ? 17.760 -54.500 -23.709 1.00 15.70 ? 226 ILE A O 1 ATOM 1612 C CB . ILE A 1 206 ? 17.972 -53.109 -26.741 1.00 19.25 ? 226 ILE A CB 1 ATOM 1613 C CG1 . ILE A 1 206 ? 17.183 -52.331 -27.796 1.00 21.42 ? 226 ILE A CG1 1 ATOM 1614 C CG2 . ILE A 1 206 ? 17.718 -54.601 -26.958 1.00 18.78 ? 226 ILE A CG2 1 ATOM 1615 C CD1 . ILE A 1 206 ? 17.749 -52.483 -29.224 1.00 21.45 ? 226 ILE A CD1 1 ATOM 1616 N N . TRP A 1 207 ? 19.629 -53.231 -24.174 1.00 16.57 ? 227 TRP A N 1 ATOM 1617 C CA . TRP A 1 207 ? 20.505 -54.048 -23.354 1.00 15.87 ? 227 TRP A CA 1 ATOM 1618 C C . TRP A 1 207 ? 20.149 -53.931 -21.889 1.00 14.06 ? 227 TRP A C 1 ATOM 1619 O O . TRP A 1 207 ? 20.148 -54.932 -21.160 1.00 15.85 ? 227 TRP A O 1 ATOM 1620 C CB . TRP A 1 207 ? 21.984 -53.714 -23.624 1.00 17.62 ? 227 TRP A CB 1 ATOM 1621 C CG . TRP A 1 207 ? 22.325 -53.805 -25.104 1.00 18.43 ? 227 TRP A CG 1 ATOM 1622 C CD1 . TRP A 1 207 ? 21.706 -54.572 -26.069 1.00 20.70 ? 227 TRP A CD1 1 ATOM 1623 C CD2 . TRP A 1 207 ? 23.356 -53.097 -25.766 1.00 19.44 ? 227 TRP A CD2 1 ATOM 1624 N NE1 . TRP A 1 207 ? 22.313 -54.375 -27.301 1.00 20.56 ? 227 TRP A NE1 1 ATOM 1625 C CE2 . TRP A 1 207 ? 23.346 -53.490 -27.125 1.00 21.06 ? 227 TRP A CE2 1 ATOM 1626 C CE3 . TRP A 1 207 ? 24.364 -52.212 -25.319 1.00 22.06 ? 227 TRP A CE3 1 ATOM 1627 C CZ2 . TRP A 1 207 ? 24.298 -52.981 -28.063 1.00 20.99 ? 227 TRP A CZ2 1 ATOM 1628 C CZ3 . TRP A 1 207 ? 25.279 -51.708 -26.243 1.00 20.66 ? 227 TRP A CZ3 1 ATOM 1629 C CH2 . TRP A 1 207 ? 25.249 -52.101 -27.578 1.00 19.29 ? 227 TRP A CH2 1 ATOM 1630 N N . ALA A 1 208 ? 19.909 -52.729 -21.440 1.00 13.66 ? 228 ALA A N 1 ATOM 1631 C CA . ALA A 1 208 ? 19.522 -52.471 -20.052 1.00 15.26 ? 228 ALA A CA 1 ATOM 1632 C C . ALA A 1 208 ? 18.198 -53.199 -19.714 1.00 15.84 ? 228 ALA A C 1 ATOM 1633 O O . ALA A 1 208 ? 18.084 -53.843 -18.653 1.00 14.78 ? 228 ALA A O 1 ATOM 1634 C CB . ALA A 1 208 ? 19.376 -50.968 -19.766 1.00 15.26 ? 228 ALA A CB 1 ATOM 1635 N N . ALA A 1 209 ? 17.209 -53.057 -20.601 1.00 17.16 ? 229 ALA A N 1 ATOM 1636 C CA . ALA A 1 209 ? 15.896 -53.748 -20.412 1.00 18.00 ? 229 ALA A CA 1 ATOM 1637 C C . ALA A 1 209 ? 16.083 -55.258 -20.296 1.00 18.17 ? 229 ALA A C 1 ATOM 1638 O O . ALA A 1 209 ? 15.494 -55.906 -19.437 1.00 16.25 ? 229 ALA A O 1 ATOM 1639 C CB . ALA A 1 209 ? 14.901 -53.411 -21.531 1.00 18.31 ? 229 ALA A CB 1 ATOM 1640 N N . ASP A 1 210 ? 16.947 -55.795 -21.164 1.00 17.58 ? 230 ASP A N 1 ATOM 1641 C CA . ASP A 1 210 ? 17.212 -57.205 -21.180 1.00 19.05 ? 230 ASP A CA 1 ATOM 1642 C C . ASP A 1 210 ? 17.789 -57.688 -19.851 1.00 19.06 ? 230 ASP A C 1 ATOM 1643 O O . ASP A 1 210 ? 17.251 -58.615 -19.221 1.00 16.30 ? 230 ASP A O 1 ATOM 1644 C CB . ASP A 1 210 ? 18.182 -57.476 -22.342 1.00 22.38 ? 230 ASP A CB 1 ATOM 1645 C CG . ASP A 1 210 ? 18.575 -58.910 -22.490 1.00 22.74 ? 230 ASP A CG 1 ATOM 1646 O OD1 . ASP A 1 210 ? 17.851 -59.820 -22.098 1.00 25.71 ? 230 ASP A OD1 1 ATOM 1647 O OD2 . ASP A 1 210 ? 19.580 -59.120 -23.202 1.00 25.13 ? 230 ASP A OD2 1 ATOM 1648 N N . ALA A 1 211 ? 18.878 -57.031 -19.389 1.00 16.83 ? 231 ALA A N 1 ATOM 1649 C CA . ALA A 1 211 ? 19.455 -57.385 -18.092 1.00 16.89 ? 231 ALA A CA 1 ATOM 1650 C C . ALA A 1 211 ? 18.431 -57.203 -16.952 1.00 15.69 ? 231 ALA A C 1 ATOM 1651 O O . ALA A 1 211 ? 18.345 -57.991 -15.997 1.00 15.10 ? 231 ALA A O 1 ATOM 1652 C CB . ALA A 1 211 ? 20.732 -56.534 -17.815 1.00 16.76 ? 231 ALA A CB 1 ATOM 1653 N N . ASN A 1 212 ? 17.698 -56.106 -17.025 1.00 15.53 ? 232 ASN A N 1 ATOM 1654 C CA . ASN A 1 212 ? 16.671 -55.813 -16.000 1.00 16.95 ? 232 ASN A CA 1 ATOM 1655 C C . ASN A 1 212 ? 15.618 -56.922 -15.816 1.00 16.20 ? 232 ASN A C 1 ATOM 1656 O O . ASN A 1 212 ? 15.141 -57.108 -14.704 1.00 18.26 ? 232 ASN A O 1 ATOM 1657 C CB . ASN A 1 212 ? 16.011 -54.455 -16.297 1.00 16.89 ? 232 ASN A CB 1 ATOM 1658 C CG . ASN A 1 212 ? 14.792 -54.174 -15.412 1.00 16.29 ? 232 ASN A CG 1 ATOM 1659 O OD1 . ASN A 1 212 ? 13.690 -54.402 -15.856 1.00 16.25 ? 232 ASN A OD1 1 ATOM 1660 N ND2 . ASN A 1 212 ? 14.999 -53.619 -14.244 1.00 16.40 ? 232 ASN A ND2 1 ATOM 1661 N N . THR A 1 213 ? 15.251 -57.630 -16.868 1.00 15.89 ? 233 THR A N 1 ATOM 1662 C CA . THR A 1 213 ? 14.246 -58.663 -16.705 1.00 17.24 ? 233 THR A CA 1 ATOM 1663 C C . THR A 1 213 ? 14.698 -59.709 -15.696 1.00 18.79 ? 233 THR A C 1 ATOM 1664 O O . THR A 1 213 ? 13.871 -60.294 -14.993 1.00 17.35 ? 233 THR A O 1 ATOM 1665 C CB . THR A 1 213 ? 13.879 -59.400 -17.996 1.00 18.90 ? 233 THR A CB 1 ATOM 1666 O OG1 . THR A 1 213 ? 14.999 -60.179 -18.475 1.00 19.04 ? 233 THR A OG1 1 ATOM 1667 C CG2 . THR A 1 213 ? 13.373 -58.431 -19.087 1.00 20.01 ? 233 THR A CG2 1 ATOM 1668 N N . TYR A 1 214 ? 16.027 -59.931 -15.634 1.00 17.16 ? 234 TYR A N 1 ATOM 1669 C CA . TYR A 1 214 ? 16.588 -60.892 -14.709 1.00 17.40 ? 234 TYR A CA 1 ATOM 1670 C C . TYR A 1 214 ? 16.524 -60.484 -13.237 1.00 17.89 ? 234 TYR A C 1 ATOM 1671 O O . TYR A 1 214 ? 16.623 -61.327 -12.342 1.00 16.53 ? 234 TYR A O 1 ATOM 1672 C CB . TYR A 1 214 ? 18.013 -61.308 -15.134 1.00 17.65 ? 234 TYR A CB 1 ATOM 1673 C CG . TYR A 1 214 ? 18.002 -62.055 -16.436 1.00 18.19 ? 234 TYR A CG 1 ATOM 1674 C CD1 . TYR A 1 214 ? 17.710 -63.400 -16.466 1.00 18.47 ? 234 TYR A CD1 1 ATOM 1675 C CD2 . TYR A 1 214 ? 18.191 -61.390 -17.664 1.00 17.86 ? 234 TYR A CD2 1 ATOM 1676 C CE1 . TYR A 1 214 ? 17.661 -64.091 -17.669 1.00 18.24 ? 234 TYR A CE1 1 ATOM 1677 C CE2 . TYR A 1 214 ? 18.130 -62.077 -18.863 1.00 18.35 ? 234 TYR A CE2 1 ATOM 1678 C CZ . TYR A 1 214 ? 17.853 -63.420 -18.844 1.00 18.65 ? 234 TYR A CZ 1 ATOM 1679 O OH . TYR A 1 214 ? 17.827 -64.066 -20.031 1.00 20.19 ? 234 TYR A OH 1 ATOM 1680 N N . VAL A 1 215 ? 16.394 -59.192 -12.973 1.00 19.17 ? 235 VAL A N 1 ATOM 1681 C CA . VAL A 1 215 ? 16.140 -58.744 -11.610 1.00 18.48 ? 235 VAL A CA 1 ATOM 1682 C C . VAL A 1 215 ? 14.869 -59.452 -11.048 1.00 23.23 ? 235 VAL A C 1 ATOM 1683 O O . VAL A 1 215 ? 14.863 -59.954 -9.867 1.00 21.15 ? 235 VAL A O 1 ATOM 1684 C CB . VAL A 1 215 ? 15.955 -57.251 -11.524 1.00 18.94 ? 235 VAL A CB 1 ATOM 1685 C CG1 . VAL A 1 215 ? 15.631 -56.839 -10.088 1.00 18.81 ? 235 VAL A CG1 1 ATOM 1686 C CG2 . VAL A 1 215 ? 17.203 -56.496 -12.006 1.00 19.43 ? 235 VAL A CG2 1 ATOM 1687 N N . CYS A 1 216 ? 13.821 -59.509 -11.885 1.00 21.07 ? 236 CYS A N 1 ATOM 1688 C CA . CYS A 1 216 ? 12.569 -60.212 -11.508 1.00 22.68 ? 236 CYS A CA 1 ATOM 1689 C C . CYS A 1 216 ? 12.670 -61.718 -11.578 1.00 20.96 ? 236 CYS A C 1 ATOM 1690 O O . CYS A 1 216 ? 12.192 -62.412 -10.696 1.00 22.29 ? 236 CYS A O 1 ATOM 1691 C CB . CYS A 1 216 ? 11.383 -59.732 -12.355 1.00 21.53 ? 236 CYS A CB 1 ATOM 1692 S SG . CYS A 1 216 ? 10.818 -58.097 -11.893 1.00 22.13 ? 236 CYS A SG 1 ATOM 1693 N N . SER A 1 217 ? 13.253 -62.228 -12.654 1.00 20.92 ? 237 SER A N 1 ATOM 1694 C CA . SER A 1 217 ? 13.230 -63.648 -12.881 1.00 20.41 ? 237 SER A CA 1 ATOM 1695 C C . SER A 1 217 ? 14.193 -64.423 -11.969 1.00 21.86 ? 237 SER A C 1 ATOM 1696 O O . SER A 1 217 ? 13.986 -65.598 -11.712 1.00 21.98 ? 237 SER A O 1 ATOM 1697 C CB . SER A 1 217 ? 13.496 -63.978 -14.354 1.00 20.53 ? 237 SER A CB 1 ATOM 1698 O OG . SER A 1 217 ? 14.852 -63.804 -14.717 1.00 19.59 ? 237 SER A OG 1 ATOM 1699 N N . THR A 1 218 ? 15.275 -63.775 -11.553 1.00 21.23 ? 238 THR A N 1 ATOM 1700 C CA . THR A 1 218 ? 16.452 -64.480 -11.033 1.00 21.04 ? 238 THR A CA 1 ATOM 1701 C C . THR A 1 218 ? 17.041 -63.860 -9.779 1.00 19.35 ? 238 THR A C 1 ATOM 1702 O O . THR A 1 218 ? 17.243 -64.561 -8.803 1.00 19.53 ? 238 THR A O 1 ATOM 1703 C CB . THR A 1 218 ? 17.541 -64.634 -12.133 1.00 20.40 ? 238 THR A CB 1 ATOM 1704 O OG1 . THR A 1 218 ? 16.943 -65.181 -13.318 1.00 18.34 ? 238 THR A OG1 1 ATOM 1705 C CG2 . THR A 1 218 ? 18.674 -65.543 -11.678 1.00 22.31 ? 238 THR A CG2 1 ATOM 1706 N N . VAL A 1 219 ? 17.287 -62.567 -9.794 1.00 16.91 ? 239 VAL A N 1 ATOM 1707 C CA . VAL A 1 219 ? 17.954 -61.918 -8.717 1.00 17.64 ? 239 VAL A CA 1 ATOM 1708 C C . VAL A 1 219 ? 17.099 -61.930 -7.448 1.00 19.38 ? 239 VAL A C 1 ATOM 1709 O O . VAL A 1 219 ? 17.588 -62.244 -6.360 1.00 17.40 ? 239 VAL A O 1 ATOM 1710 C CB . VAL A 1 219 ? 18.376 -60.466 -9.064 1.00 19.91 ? 239 VAL A CB 1 ATOM 1711 C CG1 . VAL A 1 219 ? 19.095 -59.798 -7.899 1.00 20.63 ? 239 VAL A CG1 1 ATOM 1712 C CG2 . VAL A 1 219 ? 19.315 -60.433 -10.278 1.00 20.52 ? 239 VAL A CG2 1 ATOM 1713 N N . LEU A 1 220 ? 15.846 -61.515 -7.600 1.00 20.12 ? 240 LEU A N 1 ATOM 1714 C CA . LEU A 1 220 ? 14.971 -61.222 -6.461 1.00 19.03 ? 240 LEU A CA 1 ATOM 1715 C C . LEU A 1 220 ? 13.738 -62.115 -6.358 1.00 17.51 ? 240 LEU A C 1 ATOM 1716 O O . LEU A 1 220 ? 12.980 -61.927 -5.427 1.00 17.95 ? 240 LEU A O 1 ATOM 1717 C CB . LEU A 1 220 ? 14.533 -59.738 -6.500 1.00 19.08 ? 240 LEU A CB 1 ATOM 1718 C CG . LEU A 1 220 ? 15.632 -58.704 -6.226 1.00 18.78 ? 240 LEU A CG 1 ATOM 1719 C CD1 . LEU A 1 220 ? 15.086 -57.301 -6.321 1.00 19.12 ? 240 LEU A CD1 1 ATOM 1720 C CD2 . LEU A 1 220 ? 16.282 -58.828 -4.863 1.00 18.92 ? 240 LEU A CD2 1 ATOM 1721 N N . ASP A 1 221 ? 13.555 -63.072 -7.249 1.00 16.63 ? 241 ASP A N 1 ATOM 1722 C CA . ASP A 1 221 ? 12.304 -63.844 -7.254 1.00 18.58 ? 241 ASP A CA 1 ATOM 1723 C C . ASP A 1 221 ? 12.058 -64.683 -5.972 1.00 19.33 ? 241 ASP A C 1 ATOM 1724 O O . ASP A 1 221 ? 10.931 -64.934 -5.642 1.00 17.39 ? 241 ASP A O 1 ATOM 1725 C CB . ASP A 1 221 ? 12.125 -64.720 -8.491 1.00 18.70 ? 241 ASP A CB 1 ATOM 1726 C CG . ASP A 1 221 ? 13.168 -65.779 -8.608 1.00 21.78 ? 241 ASP A CG 1 ATOM 1727 O OD1 . ASP A 1 221 ? 14.339 -65.454 -8.352 1.00 22.31 ? 241 ASP A OD1 1 ATOM 1728 O OD2 . ASP A 1 221 ? 12.815 -66.904 -8.980 1.00 27.40 ? 241 ASP A OD2 1 ATOM 1729 N N . ASP A 1 222 ? 13.114 -65.053 -5.269 1.00 18.93 ? 242 ASP A N 1 ATOM 1730 C CA . ASP A 1 222 ? 12.978 -65.813 -3.991 1.00 21.24 ? 242 ASP A CA 1 ATOM 1731 C C . ASP A 1 222 ? 12.428 -64.981 -2.881 1.00 18.76 ? 242 ASP A C 1 ATOM 1732 O O . ASP A 1 222 ? 11.888 -65.519 -1.883 1.00 19.91 ? 242 ASP A O 1 ATOM 1733 C CB . ASP A 1 222 ? 14.304 -66.426 -3.571 1.00 20.45 ? 242 ASP A CB 1 ATOM 1734 C CG . ASP A 1 222 ? 14.869 -67.331 -4.649 1.00 22.67 ? 242 ASP A CG 1 ATOM 1735 O OD1 . ASP A 1 222 ? 14.140 -68.227 -5.143 1.00 21.94 ? 242 ASP A OD1 1 ATOM 1736 O OD2 . ASP A 1 222 ? 16.054 -67.113 -4.995 1.00 24.34 ? 242 ASP A OD2 1 ATOM 1737 N N . GLY A 1 223 ? 12.581 -63.674 -3.027 1.00 16.63 ? 243 GLY A N 1 ATOM 1738 C CA . GLY A 1 223 ? 12.084 -62.709 -2.072 1.00 17.35 ? 243 GLY A CA 1 ATOM 1739 C C . GLY A 1 223 ? 13.170 -62.299 -1.059 1.00 17.90 ? 243 GLY A C 1 ATOM 1740 O O . GLY A 1 223 ? 14.123 -63.052 -0.775 1.00 18.13 ? 243 GLY A O 1 ATOM 1741 N N . LEU A 1 224 ? 13.000 -61.127 -0.494 1.00 18.36 ? 244 LEU A N 1 ATOM 1742 C CA . LEU A 1 224 ? 13.969 -60.601 0.441 1.00 21.21 ? 244 LEU A CA 1 ATOM 1743 C C . LEU A 1 224 ? 14.156 -61.389 1.763 1.00 22.92 ? 244 LEU A C 1 ATOM 1744 O O . LEU A 1 224 ? 15.284 -61.386 2.302 1.00 21.85 ? 244 LEU A O 1 ATOM 1745 C CB . LEU A 1 224 ? 13.668 -59.191 0.770 1.00 20.83 ? 244 LEU A CB 1 ATOM 1746 C CG . LEU A 1 224 ? 13.772 -58.230 -0.421 1.00 23.22 ? 244 LEU A CG 1 ATOM 1747 C CD1 . LEU A 1 224 ? 13.445 -56.827 0.083 1.00 23.11 ? 244 LEU A CD1 1 ATOM 1748 C CD2 . LEU A 1 224 ? 15.175 -58.237 -1.036 1.00 24.09 ? 244 LEU A CD2 1 ATOM 1749 N N . ALA A 1 225 ? 13.130 -62.097 2.232 1.00 20.94 ? 245 ALA A N 1 ATOM 1750 C CA . ALA A 1 225 ? 13.269 -62.870 3.467 1.00 19.73 ? 245 ALA A CA 1 ATOM 1751 C C . ALA A 1 225 ? 14.220 -64.049 3.215 1.00 20.48 ? 245 ALA A C 1 ATOM 1752 O O . ALA A 1 225 ? 15.122 -64.282 4.004 1.00 23.37 ? 245 ALA A O 1 ATOM 1753 C CB . ALA A 1 225 ? 11.934 -63.361 4.009 1.00 19.42 ? 245 ALA A CB 1 ATOM 1754 N N . TYR A 1 226 ? 14.021 -64.775 2.116 1.00 21.77 ? 246 TYR A N 1 ATOM 1755 C CA . TYR A 1 226 ? 14.927 -65.853 1.702 1.00 23.13 ? 246 TYR A CA 1 ATOM 1756 C C . TYR A 1 226 ? 16.389 -65.338 1.578 1.00 26.06 ? 246 TYR A C 1 ATOM 1757 O O . TYR A 1 226 ? 17.339 -65.909 2.093 1.00 24.53 ? 246 TYR A O 1 ATOM 1758 C CB . TYR A 1 226 ? 14.463 -66.448 0.383 1.00 23.24 ? 246 TYR A CB 1 ATOM 1759 C CG . TYR A 1 226 ? 15.412 -67.486 -0.200 1.00 24.33 ? 246 TYR A CG 1 ATOM 1760 C CD1 . TYR A 1 226 ? 16.491 -67.096 -0.999 1.00 24.45 ? 246 TYR A CD1 1 ATOM 1761 C CD2 . TYR A 1 226 ? 15.257 -68.854 0.049 1.00 22.72 ? 246 TYR A CD2 1 ATOM 1762 C CE1 . TYR A 1 226 ? 17.372 -68.009 -1.539 1.00 25.57 ? 246 TYR A CE1 1 ATOM 1763 C CE2 . TYR A 1 226 ? 16.158 -69.783 -0.484 1.00 23.35 ? 246 TYR A CE2 1 ATOM 1764 C CZ . TYR A 1 226 ? 17.219 -69.359 -1.290 1.00 25.12 ? 246 TYR A CZ 1 ATOM 1765 O OH . TYR A 1 226 ? 18.168 -70.239 -1.863 1.00 24.43 ? 246 TYR A OH 1 ATOM 1766 N N . ILE A 1 227 ? 16.531 -64.223 0.882 1.00 25.58 ? 247 ILE A N 1 ATOM 1767 C CA . ILE A 1 227 ? 17.820 -63.649 0.593 1.00 24.36 ? 247 ILE A CA 1 ATOM 1768 C C . ILE A 1 227 ? 18.570 -63.195 1.887 1.00 25.29 ? 247 ILE A C 1 ATOM 1769 O O . ILE A 1 227 ? 19.771 -63.252 1.907 1.00 25.54 ? 247 ILE A O 1 ATOM 1770 C CB . ILE A 1 227 ? 17.638 -62.514 -0.460 1.00 23.33 ? 247 ILE A CB 1 ATOM 1771 C CG1 . ILE A 1 227 ? 17.432 -63.131 -1.870 1.00 24.44 ? 247 ILE A CG1 1 ATOM 1772 C CG2 . ILE A 1 227 ? 18.816 -61.609 -0.512 1.00 24.85 ? 247 ILE A CG2 1 ATOM 1773 C CD1 . ILE A 1 227 ? 16.865 -62.153 -2.889 1.00 25.60 ? 247 ILE A CD1 1 ATOM 1774 N N . ASN A 1 228 ? 17.837 -62.711 2.888 1.00 25.79 ? 248 ASN A N 1 ATOM 1775 C CA . ASN A 1 228 ? 18.339 -62.321 4.208 1.00 26.78 ? 248 ASN A CA 1 ATOM 1776 C C . ASN A 1 228 ? 18.827 -63.486 5.053 1.00 28.29 ? 248 ASN A C 1 ATOM 1777 O O . ASN A 1 228 ? 19.551 -63.304 5.994 1.00 28.07 ? 248 ASN A O 1 ATOM 1778 C CB . ASN A 1 228 ? 17.193 -61.763 5.039 1.00 28.56 ? 248 ASN A CB 1 ATOM 1779 C CG . ASN A 1 228 ? 17.606 -60.755 6.114 1.00 32.58 ? 248 ASN A CG 1 ATOM 1780 O OD1 . ASN A 1 228 ? 18.627 -60.089 6.036 1.00 28.85 ? 248 ASN A OD1 1 ATOM 1781 N ND2 . ASN A 1 228 ? 16.753 -60.623 7.138 1.00 38.71 ? 248 ASN A ND2 1 ATOM 1782 N N . SER A 1 229 ? 18.326 -64.658 4.773 1.00 27.76 ? 249 SER A N 1 ATOM 1783 C CA . SER A 1 229 ? 18.399 -65.732 5.754 1.00 31.82 ? 249 SER A CA 1 ATOM 1784 C C . SER A 1 229 ? 18.993 -67.016 5.213 1.00 32.98 ? 249 SER A C 1 ATOM 1785 O O . SER A 1 229 ? 18.997 -68.015 5.919 1.00 32.53 ? 249 SER A O 1 ATOM 1786 C CB . SER A 1 229 ? 16.978 -65.987 6.284 1.00 31.99 ? 249 SER A CB 1 ATOM 1787 O OG . SER A 1 229 ? 16.218 -66.630 5.274 1.00 32.30 ? 249 SER A OG 1 ATOM 1788 N N . THR A 1 230 ? 19.521 -66.992 3.997 1.00 28.79 ? 250 THR A N 1 ATOM 1789 C CA . THR A 1 230 ? 20.068 -68.174 3.389 1.00 29.45 ? 250 THR A CA 1 ATOM 1790 C C . THR A 1 230 ? 21.453 -67.866 2.841 1.00 32.19 ? 250 THR A C 1 ATOM 1791 O O . THR A 1 230 ? 21.711 -66.768 2.274 1.00 30.56 ? 250 THR A O 1 ATOM 1792 C CB . THR A 1 230 ? 19.179 -68.626 2.205 1.00 32.64 ? 250 THR A CB 1 ATOM 1793 O OG1 . THR A 1 230 ? 17.798 -68.589 2.590 1.00 33.61 ? 250 THR A OG1 1 ATOM 1794 C CG2 . THR A 1 230 ? 19.530 -70.005 1.709 1.00 31.82 ? 250 THR A CG2 1 ATOM 1795 N N . ASP A 1 231 ? 22.351 -68.835 2.978 1.00 29.13 ? 251 ASP A N 1 ATOM 1796 C CA . ASP A 1 231 ? 23.666 -68.693 2.362 1.00 30.26 ? 251 ASP A CA 1 ATOM 1797 C C . ASP A 1 231 ? 23.480 -68.838 0.844 1.00 26.69 ? 251 ASP A C 1 ATOM 1798 O O . ASP A 1 231 ? 23.055 -69.877 0.349 1.00 27.34 ? 251 ASP A O 1 ATOM 1799 C CB . ASP A 1 231 ? 24.653 -69.716 2.900 1.00 31.87 ? 251 ASP A CB 1 ATOM 1800 C CG . ASP A 1 231 ? 26.082 -69.418 2.458 1.00 31.68 ? 251 ASP A CG 1 ATOM 1801 O OD1 . ASP A 1 231 ? 26.333 -69.371 1.232 1.00 28.09 ? 251 ASP A OD1 1 ATOM 1802 O OD2 . ASP A 1 231 ? 26.943 -69.219 3.348 1.00 32.25 ? 251 ASP A OD2 1 ATOM 1803 N N . LEU A 1 232 ? 23.836 -67.788 0.118 1.00 24.36 ? 252 LEU A N 1 ATOM 1804 C CA . LEU A 1 232 ? 23.565 -67.720 -1.326 1.00 24.08 ? 252 LEU A CA 1 ATOM 1805 C C . LEU A 1 232 ? 24.567 -68.452 -2.239 1.00 26.11 ? 252 LEU A C 1 ATOM 1806 O O . LEU A 1 232 ? 24.384 -68.467 -3.471 1.00 25.09 ? 252 LEU A O 1 ATOM 1807 C CB . LEU A 1 232 ? 23.361 -66.273 -1.717 1.00 23.61 ? 252 LEU A CB 1 ATOM 1808 C CG . LEU A 1 232 ? 22.239 -65.566 -0.908 1.00 24.20 ? 252 LEU A CG 1 ATOM 1809 C CD1 . LEU A 1 232 ? 22.035 -64.120 -1.379 1.00 24.28 ? 252 LEU A CD1 1 ATOM 1810 C CD2 . LEU A 1 232 ? 20.894 -66.330 -0.988 1.00 23.13 ? 252 LEU A CD2 1 ATOM 1811 N N . SER A 1 233 ? 25.599 -69.092 -1.652 1.00 25.04 ? 253 SER A N 1 ATOM 1812 C CA . SER A 1 233 ? 26.515 -69.953 -2.451 1.00 25.72 ? 253 SER A CA 1 ATOM 1813 C C . SER A 1 233 ? 25.959 -71.322 -2.786 1.00 27.64 ? 253 SER A C 1 ATOM 1814 O O . SER A 1 233 ? 26.621 -72.094 -3.482 1.00 26.84 ? 253 SER A O 1 ATOM 1815 C CB . SER A 1 233 ? 27.877 -70.102 -1.776 1.00 27.74 ? 253 SER A CB 1 ATOM 1816 O OG . SER A 1 233 ? 27.756 -70.770 -0.533 1.00 27.48 ? 253 SER A OG 1 ATOM 1817 N N . GLY A 1 234 ? 24.756 -71.620 -2.303 1.00 27.46 ? 254 GLY A N 1 ATOM 1818 C CA . GLY A 1 234 ? 24.078 -72.875 -2.623 1.00 29.33 ? 254 GLY A CA 1 ATOM 1819 C C . GLY A 1 234 ? 23.212 -72.779 -3.862 1.00 31.38 ? 254 GLY A C 1 ATOM 1820 O O . GLY A 1 234 ? 23.686 -72.463 -4.960 1.00 30.93 ? 254 GLY A O 1 ATOM 1821 N N . GLU A 1 235 ? 21.923 -73.050 -3.691 1.00 30.26 ? 255 GLU A N 1 ATOM 1822 C CA . GLU A 1 235 ? 21.003 -73.062 -4.826 1.00 30.65 ? 255 GLU A CA 1 ATOM 1823 C C . GLU A 1 235 ? 20.909 -71.719 -5.567 1.00 25.63 ? 255 GLU A C 1 ATOM 1824 O O . GLU A 1 235 ? 20.623 -71.683 -6.752 1.00 30.24 ? 255 GLU A O 1 ATOM 1825 C CB . GLU A 1 235 ? 19.605 -73.423 -4.339 1.00 37.13 ? 255 GLU A CB 1 ATOM 1826 C CG . GLU A 1 235 ? 19.508 -74.854 -3.867 1.00 45.51 ? 255 GLU A CG 1 ATOM 1827 C CD . GLU A 1 235 ? 18.052 -75.282 -3.662 1.00 56.23 ? 255 GLU A CD 1 ATOM 1828 O OE1 . GLU A 1 235 ? 17.317 -74.631 -2.865 1.00 49.99 ? 255 GLU A OE1 1 ATOM 1829 O OE2 . GLU A 1 235 ? 17.642 -76.261 -4.324 1.00 60.92 ? 255 GLU A OE2 1 ATOM 1830 N N . TYR A 1 236 ? 21.077 -70.639 -4.840 1.00 24.03 ? 256 TYR A N 1 ATOM 1831 C CA . TYR A 1 236 ? 20.968 -69.304 -5.419 1.00 24.53 ? 256 TYR A CA 1 ATOM 1832 C C . TYR A 1 236 ? 22.077 -69.127 -6.493 1.00 24.67 ? 256 TYR A C 1 ATOM 1833 O O . TYR A 1 236 ? 21.829 -68.704 -7.623 1.00 24.09 ? 256 TYR A O 1 ATOM 1834 C CB . TYR A 1 236 ? 21.056 -68.257 -4.315 1.00 24.32 ? 256 TYR A CB 1 ATOM 1835 C CG . TYR A 1 236 ? 20.832 -66.849 -4.837 1.00 25.58 ? 256 TYR A CG 1 ATOM 1836 C CD1 . TYR A 1 236 ? 21.894 -66.096 -5.345 1.00 25.09 ? 256 TYR A CD1 1 ATOM 1837 C CD2 . TYR A 1 236 ? 19.531 -66.265 -4.824 1.00 24.93 ? 256 TYR A CD2 1 ATOM 1838 C CE1 . TYR A 1 236 ? 21.684 -64.807 -5.835 1.00 24.04 ? 256 TYR A CE1 1 ATOM 1839 C CE2 . TYR A 1 236 ? 19.306 -64.998 -5.322 1.00 24.18 ? 256 TYR A CE2 1 ATOM 1840 C CZ . TYR A 1 236 ? 20.380 -64.259 -5.838 1.00 23.45 ? 256 TYR A CZ 1 ATOM 1841 O OH . TYR A 1 236 ? 20.146 -62.988 -6.311 1.00 20.18 ? 256 TYR A OH 1 ATOM 1842 N N . TYR A 1 237 ? 23.302 -69.472 -6.106 1.00 24.42 ? 257 TYR A N 1 ATOM 1843 C CA . TYR A 1 237 ? 24.410 -69.541 -7.053 1.00 24.12 ? 257 TYR A CA 1 ATOM 1844 C C . TYR A 1 237 ? 24.105 -70.431 -8.246 1.00 24.35 ? 257 TYR A C 1 ATOM 1845 O O . TYR A 1 237 ? 24.361 -70.061 -9.402 1.00 22.99 ? 257 TYR A O 1 ATOM 1846 C CB . TYR A 1 237 ? 25.710 -69.973 -6.361 1.00 24.21 ? 257 TYR A CB 1 ATOM 1847 C CG . TYR A 1 237 ? 26.832 -70.272 -7.335 1.00 25.58 ? 257 TYR A CG 1 ATOM 1848 C CD1 . TYR A 1 237 ? 27.533 -69.243 -7.966 1.00 24.31 ? 257 TYR A CD1 1 ATOM 1849 C CD2 . TYR A 1 237 ? 27.184 -71.584 -7.636 1.00 27.19 ? 257 TYR A CD2 1 ATOM 1850 C CE1 . TYR A 1 237 ? 28.578 -69.505 -8.843 1.00 24.79 ? 257 TYR A CE1 1 ATOM 1851 C CE2 . TYR A 1 237 ? 28.215 -71.861 -8.529 1.00 29.66 ? 257 TYR A CE2 1 ATOM 1852 C CZ . TYR A 1 237 ? 28.917 -70.805 -9.137 1.00 28.95 ? 257 TYR A CZ 1 ATOM 1853 O OH . TYR A 1 237 ? 29.964 -71.076 -10.000 1.00 27.19 ? 257 TYR A OH 1 ATOM 1854 N N . ASP A 1 238 ? 23.586 -71.619 -7.977 1.00 24.87 ? 258 ASP A N 1 ATOM 1855 C CA . ASP A 1 238 ? 23.363 -72.605 -9.046 1.00 25.91 ? 258 ASP A CA 1 ATOM 1856 C C . ASP A 1 238 ? 22.417 -72.092 -10.126 1.00 24.68 ? 258 ASP A C 1 ATOM 1857 O O . ASP A 1 238 ? 22.634 -72.306 -11.298 1.00 23.20 ? 258 ASP A O 1 ATOM 1858 C CB . ASP A 1 238 ? 22.781 -73.909 -8.506 1.00 28.47 ? 258 ASP A CB 1 ATOM 1859 C CG . ASP A 1 238 ? 23.716 -74.645 -7.535 1.00 34.15 ? 258 ASP A CG 1 ATOM 1860 O OD1 . ASP A 1 238 ? 24.971 -74.500 -7.585 1.00 34.28 ? 258 ASP A OD1 1 ATOM 1861 O OD2 . ASP A 1 238 ? 23.149 -75.416 -6.721 1.00 37.89 ? 258 ASP A OD2 1 ATOM 1862 N N . LYS A 1 239 ? 21.363 -71.412 -9.710 1.00 23.88 ? 259 LYS A N 1 ATOM 1863 C CA . LYS A 1 239 ? 20.435 -70.842 -10.695 1.00 24.34 ? 259 LYS A CA 1 ATOM 1864 C C . LYS A 1 239 ? 20.936 -69.469 -11.240 1.00 25.26 ? 259 LYS A C 1 ATOM 1865 O O . LYS A 1 239 ? 20.569 -69.089 -12.343 1.00 26.35 ? 259 LYS A O 1 ATOM 1866 C CB . LYS A 1 239 ? 19.036 -70.736 -10.133 1.00 24.71 ? 259 LYS A CB 1 ATOM 1867 C CG . LYS A 1 239 ? 18.901 -69.900 -8.884 1.00 30.38 ? 259 LYS A CG 1 ATOM 1868 C CD . LYS A 1 239 ? 18.106 -68.645 -9.139 1.00 31.80 ? 259 LYS A CD 1 ATOM 1869 C CE . LYS A 1 239 ? 18.108 -67.685 -7.974 1.00 32.42 ? 259 LYS A CE 1 ATOM 1870 N NZ . LYS A 1 239 ? 16.688 -67.264 -7.697 1.00 30.41 ? 259 LYS A NZ 1 ATOM 1871 N N . SER A 1 240 ? 21.801 -68.775 -10.508 1.00 21.94 ? 260 SER A N 1 ATOM 1872 C CA . SER A 1 240 ? 22.386 -67.508 -11.001 1.00 21.88 ? 260 SER A CA 1 ATOM 1873 C C . SER A 1 240 ? 23.426 -67.691 -12.123 1.00 22.75 ? 260 SER A C 1 ATOM 1874 O O . SER A 1 240 ? 23.482 -66.903 -13.079 1.00 21.00 ? 260 SER A O 1 ATOM 1875 C CB . SER A 1 240 ? 23.013 -66.724 -9.862 1.00 21.64 ? 260 SER A CB 1 ATOM 1876 O OG . SER A 1 240 ? 22.029 -66.274 -8.912 1.00 23.38 ? 260 SER A OG 1 ATOM 1877 N N . GLN A 1 241 ? 24.249 -68.731 -12.002 1.00 23.16 ? 261 GLN A N 1 ATOM 1878 C CA . GLN A 1 241 ? 25.359 -68.934 -12.926 1.00 24.09 ? 261 GLN A CA 1 ATOM 1879 C C . GLN A 1 241 ? 25.017 -68.880 -14.420 1.00 25.09 ? 261 GLN A C 1 ATOM 1880 O O . GLN A 1 241 ? 25.648 -68.122 -15.185 1.00 23.90 ? 261 GLN A O 1 ATOM 1881 C CB . GLN A 1 241 ? 26.123 -70.201 -12.574 1.00 25.43 ? 261 GLN A CB 1 ATOM 1882 C CG . GLN A 1 241 ? 27.295 -70.490 -13.511 1.00 26.28 ? 261 GLN A CG 1 ATOM 1883 C CD . GLN A 1 241 ? 28.114 -71.691 -13.085 1.00 30.53 ? 261 GLN A CD 1 ATOM 1884 O OE1 . GLN A 1 241 ? 27.727 -72.444 -12.176 1.00 31.19 ? 261 GLN A OE1 1 ATOM 1885 N NE2 . GLN A 1 241 ? 29.271 -71.861 -13.725 1.00 28.40 ? 261 GLN A NE2 1 ATOM 1886 N N . PRO A 1 242 ? 24.046 -69.708 -14.870 1.00 25.13 ? 262 PRO A N 1 ATOM 1887 C CA . PRO A 1 242 ? 23.701 -69.628 -16.284 1.00 24.41 ? 262 PRO A CA 1 ATOM 1888 C C . PRO A 1 242 ? 23.222 -68.245 -16.735 1.00 22.69 ? 262 PRO A C 1 ATOM 1889 O O . PRO A 1 242 ? 23.441 -67.885 -17.871 1.00 19.64 ? 262 PRO A O 1 ATOM 1890 C CB . PRO A 1 242 ? 22.605 -70.679 -16.444 1.00 25.15 ? 262 PRO A CB 1 ATOM 1891 C CG . PRO A 1 242 ? 22.090 -70.864 -15.065 1.00 27.02 ? 262 PRO A CG 1 ATOM 1892 C CD . PRO A 1 242 ? 23.246 -70.705 -14.158 1.00 26.27 ? 262 PRO A CD 1 ATOM 1893 N N . VAL A 1 243 ? 22.583 -67.495 -15.845 1.00 21.20 ? 263 VAL A N 1 ATOM 1894 C CA . VAL A 1 243 ? 22.131 -66.161 -16.186 1.00 19.99 ? 263 VAL A CA 1 ATOM 1895 C C . VAL A 1 243 ? 23.296 -65.170 -16.325 1.00 18.66 ? 263 VAL A C 1 ATOM 1896 O O . VAL A 1 243 ? 23.428 -64.527 -17.371 1.00 18.70 ? 263 VAL A O 1 ATOM 1897 C CB . VAL A 1 243 ? 21.053 -65.669 -15.175 1.00 20.47 ? 263 VAL A CB 1 ATOM 1898 C CG1 . VAL A 1 243 ? 20.718 -64.220 -15.379 1.00 19.15 ? 263 VAL A CG1 1 ATOM 1899 C CG2 . VAL A 1 243 ? 19.808 -66.511 -15.310 1.00 20.27 ? 263 VAL A CG2 1 ATOM 1900 N N . PHE A 1 244 ? 24.162 -65.063 -15.312 1.00 19.31 ? 264 PHE A N 1 ATOM 1901 C CA . PHE A 1 244 ? 25.334 -64.159 -15.490 1.00 20.08 ? 264 PHE A CA 1 ATOM 1902 C C . PHE A 1 244 ? 26.296 -64.586 -16.608 1.00 19.14 ? 264 PHE A C 1 ATOM 1903 O O . PHE A 1 244 ? 26.850 -63.719 -17.295 1.00 17.52 ? 264 PHE A O 1 ATOM 1904 C CB . PHE A 1 244 ? 26.052 -63.722 -14.207 1.00 20.19 ? 264 PHE A CB 1 ATOM 1905 C CG . PHE A 1 244 ? 26.697 -64.822 -13.407 1.00 21.44 ? 264 PHE A CG 1 ATOM 1906 C CD1 . PHE A 1 244 ? 27.911 -65.405 -13.800 1.00 22.02 ? 264 PHE A CD1 1 ATOM 1907 C CD2 . PHE A 1 244 ? 26.150 -65.204 -12.179 1.00 21.79 ? 264 PHE A CD2 1 ATOM 1908 C CE1 . PHE A 1 244 ? 28.508 -66.370 -13.024 1.00 22.04 ? 264 PHE A CE1 1 ATOM 1909 C CE2 . PHE A 1 244 ? 26.753 -66.184 -11.397 1.00 21.13 ? 264 PHE A CE2 1 ATOM 1910 C CZ . PHE A 1 244 ? 27.938 -66.755 -11.823 1.00 21.19 ? 264 PHE A CZ 1 ATOM 1911 N N . GLU A 1 245 ? 26.404 -65.877 -16.858 1.00 18.62 ? 265 GLU A N 1 ATOM 1912 C CA . GLU A 1 245 ? 27.266 -66.321 -17.947 1.00 19.99 ? 265 GLU A CA 1 ATOM 1913 C C . GLU A 1 245 ? 26.758 -65.872 -19.287 1.00 21.16 ? 265 GLU A C 1 ATOM 1914 O O . GLU A 1 245 ? 27.541 -65.402 -20.147 1.00 18.77 ? 265 GLU A O 1 ATOM 1915 C CB . GLU A 1 245 ? 27.557 -67.835 -17.900 1.00 21.31 ? 265 GLU A CB 1 ATOM 1916 C CG . GLU A 1 245 ? 28.529 -68.116 -16.774 1.00 21.26 ? 265 GLU A CG 1 ATOM 1917 C CD . GLU A 1 245 ? 28.928 -69.569 -16.557 1.00 24.27 ? 265 GLU A CD 1 ATOM 1918 O OE1 . GLU A 1 245 ? 29.820 -69.748 -15.707 1.00 21.81 ? 265 GLU A OE1 1 ATOM 1919 O OE2 . GLU A 1 245 ? 28.329 -70.499 -17.135 1.00 22.58 ? 265 GLU A OE2 1 ATOM 1920 N N . GLU A 1 246 ? 25.447 -66.033 -19.498 1.00 20.41 ? 266 GLU A N 1 ATOM 1921 C CA . GLU A 1 246 ? 24.875 -65.601 -20.748 1.00 20.65 ? 266 GLU A CA 1 ATOM 1922 C C . GLU A 1 246 ? 24.954 -64.084 -20.895 1.00 17.57 ? 266 GLU A C 1 ATOM 1923 O O . GLU A 1 246 ? 25.163 -63.591 -22.009 1.00 16.03 ? 266 GLU A O 1 ATOM 1924 C CB . GLU A 1 246 ? 23.418 -66.080 -20.916 1.00 23.55 ? 266 GLU A CB 1 ATOM 1925 C CG . GLU A 1 246 ? 22.942 -65.927 -22.334 1.00 26.51 ? 266 GLU A CG 1 ATOM 1926 C CD . GLU A 1 246 ? 21.591 -66.611 -22.596 1.00 31.08 ? 266 GLU A CD 1 ATOM 1927 O OE1 . GLU A 1 246 ? 20.652 -65.904 -22.975 1.00 31.34 ? 266 GLU A OE1 1 ATOM 1928 O OE2 . GLU A 1 246 ? 21.483 -67.833 -22.413 1.00 30.51 ? 266 GLU A OE2 1 ATOM 1929 N N . LEU A 1 247 ? 24.717 -63.364 -19.806 1.00 16.48 ? 267 LEU A N 1 ATOM 1930 C CA . LEU A 1 247 ? 24.741 -61.909 -19.862 1.00 16.91 ? 267 LEU A CA 1 ATOM 1931 C C . LEU A 1 247 ? 26.174 -61.337 -20.118 1.00 17.74 ? 267 LEU A C 1 ATOM 1932 O O . LEU A 1 247 ? 26.321 -60.330 -20.835 1.00 16.51 ? 267 LEU A O 1 ATOM 1933 C CB . LEU A 1 247 ? 24.183 -61.290 -18.594 1.00 16.99 ? 267 LEU A CB 1 ATOM 1934 C CG . LEU A 1 247 ? 22.655 -61.395 -18.499 1.00 17.26 ? 267 LEU A CG 1 ATOM 1935 C CD1 . LEU A 1 247 ? 22.197 -61.069 -17.104 1.00 20.18 ? 267 LEU A CD1 1 ATOM 1936 C CD2 . LEU A 1 247 ? 21.988 -60.468 -19.467 1.00 16.95 ? 267 LEU A CD2 1 ATOM 1937 N N . ILE A 1 248 ? 27.187 -62.006 -19.559 1.00 16.71 ? 268 ILE A N 1 ATOM 1938 C CA . ILE A 1 248 ? 28.600 -61.654 -19.844 1.00 16.79 ? 268 ILE A CA 1 ATOM 1939 C C . ILE A 1 248 ? 28.923 -61.896 -21.292 1.00 17.34 ? 268 ILE A C 1 ATOM 1940 O O . ILE A 1 248 ? 29.528 -61.063 -21.945 1.00 16.64 ? 268 ILE A O 1 ATOM 1941 C CB . ILE A 1 248 ? 29.568 -62.367 -18.883 1.00 16.38 ? 268 ILE A CB 1 ATOM 1942 C CG1 . ILE A 1 248 ? 29.407 -61.723 -17.506 1.00 15.64 ? 268 ILE A CG1 1 ATOM 1943 C CG2 . ILE A 1 248 ? 31.009 -62.305 -19.364 1.00 15.91 ? 268 ILE A CG2 1 ATOM 1944 C CD1 . ILE A 1 248 ? 30.007 -62.582 -16.382 1.00 17.18 ? 268 ILE A CD1 1 ATOM 1945 N N . ALA A 1 249 ? 28.452 -63.023 -21.814 1.00 18.00 ? 269 ALA A N 1 ATOM 1946 C CA . ALA A 1 249 ? 28.634 -63.353 -23.222 1.00 17.56 ? 269 ALA A CA 1 ATOM 1947 C C . ALA A 1 249 ? 28.003 -62.326 -24.135 1.00 17.94 ? 269 ALA A C 1 ATOM 1948 O O . ALA A 1 249 ? 28.629 -61.872 -25.089 1.00 19.39 ? 269 ALA A O 1 ATOM 1949 C CB . ALA A 1 249 ? 28.082 -64.737 -23.523 1.00 18.51 ? 269 ALA A CB 1 ATOM 1950 N N . LYS A 1 250 ? 26.761 -61.969 -23.826 1.00 17.09 ? 270 LYS A N 1 ATOM 1951 C CA . LYS A 1 250 ? 26.053 -60.922 -24.572 1.00 17.06 ? 270 LYS A CA 1 ATOM 1952 C C . LYS A 1 250 ? 26.782 -59.598 -24.528 1.00 14.87 ? 270 LYS A C 1 ATOM 1953 O O . LYS A 1 250 ? 26.876 -58.905 -25.515 1.00 14.76 ? 270 LYS A O 1 ATOM 1954 C CB . LYS A 1 250 ? 24.633 -60.675 -23.968 1.00 18.76 ? 270 LYS A CB 1 ATOM 1955 C CG . LYS A 1 250 ? 23.623 -61.719 -24.340 1.00 20.53 ? 270 LYS A CG 1 ATOM 1956 C CD . LYS A 1 250 ? 22.332 -61.507 -23.556 1.00 20.95 ? 270 LYS A CD 1 ATOM 1957 C CE . LYS A 1 250 ? 21.162 -61.971 -24.415 1.00 23.22 ? 270 LYS A CE 1 ATOM 1958 N NZ . LYS A 1 250 ? 19.904 -61.870 -23.608 1.00 23.08 ? 270 LYS A NZ 1 ATOM 1959 N N . ALA A 1 251 ? 27.217 -59.224 -23.332 1.00 14.78 ? 271 ALA A N 1 ATOM 1960 C CA . ALA A 1 251 ? 27.931 -57.971 -23.176 1.00 14.55 ? 271 ALA A CA 1 ATOM 1961 C C . ALA A 1 251 ? 29.169 -57.895 -24.087 1.00 14.08 ? 271 ALA A C 1 ATOM 1962 O O . ALA A 1 251 ? 29.364 -56.908 -24.799 1.00 13.98 ? 271 ALA A O 1 ATOM 1963 C CB . ALA A 1 251 ? 28.319 -57.783 -21.725 1.00 14.60 ? 271 ALA A CB 1 ATOM 1964 N N . GLY A 1 252 ? 29.976 -58.939 -24.061 1.00 14.75 ? 272 GLY A N 1 ATOM 1965 C CA . GLY A 1 252 ? 31.126 -59.032 -24.976 1.00 17.44 ? 272 GLY A CA 1 ATOM 1966 C C . GLY A 1 252 ? 30.797 -58.937 -26.458 1.00 17.56 ? 272 GLY A C 1 ATOM 1967 O O . GLY A 1 252 ? 31.441 -58.210 -27.240 1.00 14.96 ? 272 GLY A O 1 ATOM 1968 N N . TYR A 1 253 ? 29.744 -59.667 -26.849 1.00 19.05 ? 273 TYR A N 1 ATOM 1969 C CA . TYR A 1 253 ? 29.354 -59.748 -28.265 1.00 17.98 ? 273 TYR A CA 1 ATOM 1970 C C . TYR A 1 253 ? 28.801 -58.421 -28.735 1.00 17.99 ? 273 TYR A C 1 ATOM 1971 O O . TYR A 1 253 ? 29.139 -57.927 -29.828 1.00 17.10 ? 273 TYR A O 1 ATOM 1972 C CB . TYR A 1 253 ? 28.318 -60.861 -28.424 1.00 19.44 ? 273 TYR A CB 1 ATOM 1973 C CG . TYR A 1 253 ? 28.010 -61.280 -29.813 1.00 21.29 ? 273 TYR A CG 1 ATOM 1974 C CD1 . TYR A 1 253 ? 28.895 -62.118 -30.521 1.00 24.13 ? 273 TYR A CD1 1 ATOM 1975 C CD2 . TYR A 1 253 ? 26.821 -60.887 -30.430 1.00 23.13 ? 273 TYR A CD2 1 ATOM 1976 C CE1 . TYR A 1 253 ? 28.572 -62.537 -31.815 1.00 26.11 ? 273 TYR A CE1 1 ATOM 1977 C CE2 . TYR A 1 253 ? 26.487 -61.296 -31.723 1.00 23.91 ? 273 TYR A CE2 1 ATOM 1978 C CZ . TYR A 1 253 ? 27.372 -62.128 -32.396 1.00 26.87 ? 273 TYR A CZ 1 ATOM 1979 O OH . TYR A 1 253 ? 27.053 -62.562 -33.640 1.00 31.10 ? 273 TYR A OH 1 ATOM 1980 N N . ARG A 1 254 ? 27.972 -57.808 -27.874 1.00 15.89 ? 274 ARG A N 1 ATOM 1981 C CA . ARG A 1 254 ? 27.416 -56.498 -28.166 1.00 16.36 ? 274 ARG A CA 1 ATOM 1982 C C . ARG A 1 254 ? 28.453 -55.364 -28.158 1.00 14.39 ? 274 ARG A C 1 ATOM 1983 O O . ARG A 1 254 ? 28.421 -54.481 -29.010 1.00 14.07 ? 274 ARG A O 1 ATOM 1984 C CB . ARG A 1 254 ? 26.264 -56.154 -27.180 1.00 16.32 ? 274 ARG A CB 1 ATOM 1985 C CG . ARG A 1 254 ? 24.984 -56.951 -27.491 1.00 16.73 ? 274 ARG A CG 1 ATOM 1986 C CD . ARG A 1 254 ? 24.095 -57.109 -26.266 1.00 16.64 ? 274 ARG A CD 1 ATOM 1987 N NE . ARG A 1 254 ? 22.807 -57.697 -26.621 1.00 18.37 ? 274 ARG A NE 1 ATOM 1988 C CZ . ARG A 1 254 ? 21.795 -57.996 -25.782 1.00 18.69 ? 274 ARG A CZ 1 ATOM 1989 N NH1 . ARG A 1 254 ? 21.893 -57.780 -24.478 1.00 18.47 ? 274 ARG A NH1 1 ATOM 1990 N NH2 . ARG A 1 254 ? 20.659 -58.539 -26.259 1.00 18.04 ? 274 ARG A NH2 1 ATOM 1991 N N . LEU A 1 255 ? 29.358 -55.422 -27.178 1.00 14.52 ? 275 LEU A N 1 ATOM 1992 C CA . LEU A 1 255 ? 30.506 -54.497 -27.156 1.00 14.46 ? 275 LEU A CA 1 ATOM 1993 C C . LEU A 1 255 ? 31.297 -54.574 -28.502 1.00 14.43 ? 275 LEU A C 1 ATOM 1994 O O . LEU A 1 255 ? 31.528 -53.539 -29.131 1.00 13.00 ? 275 LEU A O 1 ATOM 1995 C CB . LEU A 1 255 ? 31.409 -54.773 -25.949 1.00 14.57 ? 275 LEU A CB 1 ATOM 1996 C CG . LEU A 1 255 ? 32.741 -53.966 -25.939 1.00 15.04 ? 275 LEU A CG 1 ATOM 1997 C CD1 . LEU A 1 255 ? 32.490 -52.464 -25.978 1.00 15.38 ? 275 LEU A CD1 1 ATOM 1998 C CD2 . LEU A 1 255 ? 33.493 -54.360 -24.691 1.00 16.20 ? 275 LEU A CD2 1 ATOM 1999 N N . ALA A 1 256 ? 31.602 -55.792 -28.938 1.00 15.43 ? 276 ALA A N 1 ATOM 2000 C CA . ALA A 1 256 ? 32.305 -55.966 -30.269 1.00 17.63 ? 276 ALA A CA 1 ATOM 2001 C C . ALA A 1 256 ? 31.508 -55.345 -31.414 1.00 17.72 ? 276 ALA A C 1 ATOM 2002 O O . ALA A 1 256 ? 32.056 -54.610 -32.245 1.00 18.28 ? 276 ALA A O 1 ATOM 2003 C CB . ALA A 1 256 ? 32.600 -57.429 -30.546 1.00 17.01 ? 276 ALA A CB 1 ATOM 2004 N N . ALA A 1 257 ? 30.184 -55.589 -31.443 1.00 19.26 ? 277 ALA A N 1 ATOM 2005 C CA . ALA A 1 257 ? 29.349 -55.048 -32.528 1.00 18.36 ? 277 ALA A CA 1 ATOM 2006 C C . ALA A 1 257 ? 29.363 -53.531 -32.520 1.00 17.52 ? 277 ALA A C 1 ATOM 2007 O O . ALA A 1 257 ? 29.468 -52.884 -33.571 1.00 17.14 ? 277 ALA A O 1 ATOM 2008 C CB . ALA A 1 257 ? 27.894 -55.578 -32.446 1.00 19.98 ? 277 ALA A CB 1 ATOM 2009 N N . TRP A 1 258 ? 29.286 -52.962 -31.310 1.00 15.73 ? 278 TRP A N 1 ATOM 2010 C CA . TRP A 1 258 ? 29.261 -51.506 -31.153 1.00 15.34 ? 278 TRP A CA 1 ATOM 2011 C C . TRP A 1 258 ? 30.604 -50.880 -31.546 1.00 14.94 ? 278 TRP A C 1 ATOM 2012 O O . TRP A 1 258 ? 30.617 -49.887 -32.232 1.00 14.83 ? 278 TRP A O 1 ATOM 2013 C CB . TRP A 1 258 ? 28.917 -51.126 -29.710 1.00 15.00 ? 278 TRP A CB 1 ATOM 2014 C CG . TRP A 1 258 ? 28.406 -49.766 -29.463 1.00 15.75 ? 278 TRP A CG 1 ATOM 2015 C CD1 . TRP A 1 258 ? 28.973 -48.846 -28.687 1.00 16.10 ? 278 TRP A CD1 1 ATOM 2016 C CD2 . TRP A 1 258 ? 27.172 -49.166 -29.959 1.00 16.33 ? 278 TRP A CD2 1 ATOM 2017 N NE1 . TRP A 1 258 ? 28.202 -47.706 -28.633 1.00 17.54 ? 278 TRP A NE1 1 ATOM 2018 C CE2 . TRP A 1 258 ? 27.087 -47.883 -29.410 1.00 17.26 ? 278 TRP A CE2 1 ATOM 2019 C CE3 . TRP A 1 258 ? 26.155 -49.589 -30.841 1.00 15.39 ? 278 TRP A CE3 1 ATOM 2020 C CZ2 . TRP A 1 258 ? 26.012 -47.010 -29.680 1.00 17.00 ? 278 TRP A CZ2 1 ATOM 2021 C CZ3 . TRP A 1 258 ? 25.118 -48.717 -31.123 1.00 15.08 ? 278 TRP A CZ3 1 ATOM 2022 C CH2 . TRP A 1 258 ? 25.039 -47.458 -30.540 1.00 15.50 ? 278 TRP A CH2 1 ATOM 2023 N N . LEU A 1 259 ? 31.699 -51.502 -31.111 1.00 15.81 ? 279 LEU A N 1 ATOM 2024 C CA . LEU A 1 259 ? 33.036 -51.066 -31.496 1.00 16.64 ? 279 LEU A CA 1 ATOM 2025 C C . LEU A 1 259 ? 33.251 -51.121 -33.027 1.00 17.26 ? 279 LEU A C 1 ATOM 2026 O O . LEU A 1 259 ? 33.745 -50.148 -33.611 1.00 17.18 ? 279 LEU A O 1 ATOM 2027 C CB . LEU A 1 259 ? 34.132 -51.846 -30.772 1.00 15.83 ? 279 LEU A CB 1 ATOM 2028 C CG . LEU A 1 259 ? 34.207 -51.623 -29.252 1.00 15.58 ? 279 LEU A CG 1 ATOM 2029 C CD1 . LEU A 1 259 ? 35.295 -52.501 -28.645 1.00 15.76 ? 279 LEU A CD1 1 ATOM 2030 C CD2 . LEU A 1 259 ? 34.372 -50.167 -28.903 1.00 15.72 ? 279 LEU A CD2 1 ATOM 2031 N N . ASP A 1 260 ? 32.820 -52.198 -33.654 1.00 18.06 ? 280 ASP A N 1 ATOM 2032 C CA . ASP A 1 260 ? 32.858 -52.286 -35.146 1.00 18.52 ? 280 ASP A CA 1 ATOM 2033 C C . ASP A 1 260 ? 32.152 -51.130 -35.777 1.00 21.18 ? 280 ASP A C 1 ATOM 2034 O O . ASP A 1 260 ? 32.705 -50.484 -36.708 1.00 20.13 ? 280 ASP A O 1 ATOM 2035 C CB . ASP A 1 260 ? 32.260 -53.583 -35.660 1.00 19.93 ? 280 ASP A CB 1 ATOM 2036 C CG . ASP A 1 260 ? 33.165 -54.777 -35.466 1.00 20.85 ? 280 ASP A CG 1 ATOM 2037 O OD1 . ASP A 1 260 ? 34.411 -54.640 -35.294 1.00 22.85 ? 280 ASP A OD1 1 ATOM 2038 O OD2 . ASP A 1 260 ? 32.630 -55.901 -35.498 1.00 24.21 ? 280 ASP A OD2 1 ATOM 2039 N N . LEU A 1 261 ? 30.959 -50.787 -35.257 1.00 18.66 ? 281 LEU A N 1 ATOM 2040 C CA . LEU A 1 261 ? 30.231 -49.660 -35.818 1.00 19.01 ? 281 LEU A CA 1 ATOM 2041 C C . LEU A 1 261 ? 30.955 -48.346 -35.642 1.00 20.37 ? 281 LEU A C 1 ATOM 2042 O O . LEU A 1 261 ? 30.983 -47.501 -36.543 1.00 19.53 ? 281 LEU A O 1 ATOM 2043 C CB . LEU A 1 261 ? 28.796 -49.520 -35.199 1.00 19.44 ? 281 LEU A CB 1 ATOM 2044 C CG . LEU A 1 261 ? 27.848 -50.625 -35.685 1.00 20.56 ? 281 LEU A CG 1 ATOM 2045 C CD1 . LEU A 1 261 ? 26.648 -50.817 -34.761 1.00 21.07 ? 281 LEU A CD1 1 ATOM 2046 C CD2 . LEU A 1 261 ? 27.398 -50.352 -37.131 1.00 20.19 ? 281 LEU A CD2 1 ATOM 2047 N N . ILE A 1 262 ? 31.462 -48.127 -34.435 1.00 19.70 ? 282 ILE A N 1 ATOM 2048 C CA . ILE A 1 262 ? 32.147 -46.862 -34.151 1.00 18.32 ? 282 ILE A CA 1 ATOM 2049 C C . ILE A 1 262 ? 33.388 -46.732 -35.058 1.00 19.11 ? 282 ILE A C 1 ATOM 2050 O O . ILE A 1 262 ? 33.689 -45.658 -35.583 1.00 18.46 ? 282 ILE A O 1 ATOM 2051 C CB . ILE A 1 262 ? 32.597 -46.791 -32.681 1.00 18.22 ? 282 ILE A CB 1 ATOM 2052 C CG1 . ILE A 1 262 ? 31.359 -46.635 -31.768 1.00 18.52 ? 282 ILE A CG1 1 ATOM 2053 C CG2 . ILE A 1 262 ? 33.577 -45.633 -32.459 1.00 17.11 ? 282 ILE A CG2 1 ATOM 2054 C CD1 . ILE A 1 262 ? 31.677 -46.885 -30.297 1.00 21.47 ? 282 ILE A CD1 1 ATOM 2055 N N . ALA A 1 263 ? 34.108 -47.820 -35.172 1.00 19.57 ? 283 ALA A N 1 ATOM 2056 C CA . ALA A 1 263 ? 35.403 -47.833 -35.928 1.00 23.39 ? 283 ALA A CA 1 ATOM 2057 C C . ALA A 1 263 ? 35.197 -47.693 -37.442 1.00 25.45 ? 283 ALA A C 1 ATOM 2058 O O . ALA A 1 263 ? 36.064 -47.301 -38.144 1.00 29.78 ? 283 ALA A O 1 ATOM 2059 C CB . ALA A 1 263 ? 36.134 -49.129 -35.651 1.00 22.12 ? 283 ALA A CB 1 ATOM 2060 N N . SER A 1 264 ? 34.024 -48.007 -37.934 1.00 29.09 ? 284 SER A N 1 ATOM 2061 C CA . SER A 1 264 ? 33.819 -48.020 -39.347 1.00 30.81 ? 284 SER A CA 1 ATOM 2062 C C . SER A 1 264 ? 33.211 -46.730 -39.877 1.00 32.47 ? 284 SER A C 1 ATOM 2063 O O . SER A 1 264 ? 32.863 -46.675 -41.043 1.00 34.62 ? 284 SER A O 1 ATOM 2064 C CB . SER A 1 264 ? 32.978 -49.254 -39.725 1.00 29.88 ? 284 SER A CB 1 ATOM 2065 O OG . SER A 1 264 ? 31.658 -49.048 -39.314 1.00 32.16 ? 284 SER A OG 1 ATOM 2066 N N . GLN A 1 265 ? 33.089 -45.669 -39.085 1.00 35.54 ? 285 GLN A N 1 ATOM 2067 C CA . GLN A 1 265 ? 32.536 -44.444 -39.659 1.00 36.55 ? 285 GLN A CA 1 ATOM 2068 C C . GLN A 1 265 ? 33.493 -43.795 -40.645 1.00 41.63 ? 285 GLN A C 1 ATOM 2069 O O . GLN A 1 265 ? 34.699 -43.662 -40.345 1.00 39.95 ? 285 GLN A O 1 ATOM 2070 C CB . GLN A 1 265 ? 32.175 -43.475 -38.583 1.00 38.87 ? 285 GLN A CB 1 ATOM 2071 C CG . GLN A 1 265 ? 30.996 -43.967 -37.757 1.00 45.39 ? 285 GLN A CG 1 ATOM 2072 C CD . GLN A 1 265 ? 29.815 -44.502 -38.586 1.00 46.53 ? 285 GLN A CD 1 ATOM 2073 O OE1 . GLN A 1 265 ? 29.336 -43.796 -39.485 1.00 54.83 ? 285 GLN A OE1 1 ATOM 2074 N NE2 . GLN A 1 265 ? 29.372 -45.748 -38.315 1.00 37.53 ? 285 GLN A NE2 1 ATOM 2075 N N . PRO A 1 266 ? 32.979 -43.392 -41.833 1.00 41.35 ? 286 PRO A N 1 ATOM 2076 C CA . PRO A 1 266 ? 33.928 -42.815 -42.795 1.00 40.44 ? 286 PRO A CA 1 ATOM 2077 C C . PRO A 1 266 ? 34.436 -41.407 -42.375 1.00 41.65 ? 286 PRO A C 1 ATOM 2078 O O . PRO A 1 266 ? 33.739 -40.663 -41.677 1.00 37.41 ? 286 PRO A O 1 ATOM 2079 C CB . PRO A 1 266 ? 33.126 -42.764 -44.112 1.00 40.83 ? 286 PRO A CB 1 ATOM 2080 C CG . PRO A 1 266 ? 31.681 -42.792 -43.724 1.00 40.82 ? 286 PRO A CG 1 ATOM 2081 C CD . PRO A 1 266 ? 31.574 -43.337 -42.316 1.00 41.24 ? 286 PRO A CD 1 ATOM 2082 N N . SER A 1 267 ? 35.647 -41.071 -42.808 1.00 40.98 ? 287 SER A N 1 ATOM 2083 C CA . SER A 1 267 ? 36.268 -39.722 -42.612 1.00 44.79 ? 287 SER A CA 1 ATOM 2084 C C . SER A 1 267 ? 37.448 -39.491 -43.598 1.00 45.99 ? 287 SER A C 1 ATOM 2085 O O . SER A 1 267 ? 37.789 -40.371 -44.418 1.00 43.20 ? 287 SER A O 1 ATOM 2086 C CB . SER A 1 267 ? 36.781 -39.556 -41.186 1.00 41.78 ? 287 SER A CB 1 ATOM 2087 O OG . SER A 1 267 ? 37.585 -40.674 -40.860 1.00 44.43 ? 287 SER A OG 1 ATOM 2088 O OXT . SER A 1 267 ? 38.096 -38.435 -43.611 1.00 48.35 ? 287 SER A OXT 1 ATOM 2089 N N . TRP B 1 1 ? 58.515 -37.853 -3.619 1.00 14.23 ? 21 TRP B N 1 ATOM 2090 C CA . TRP B 1 1 ? 58.808 -36.682 -2.813 1.00 12.96 ? 21 TRP B CA 1 ATOM 2091 C C . TRP B 1 1 ? 60.197 -36.812 -2.224 1.00 13.65 ? 21 TRP B C 1 ATOM 2092 O O . TRP B 1 1 ? 60.726 -37.905 -2.051 1.00 12.89 ? 21 TRP B O 1 ATOM 2093 C CB . TRP B 1 1 ? 57.808 -36.482 -1.628 1.00 12.73 ? 21 TRP B CB 1 ATOM 2094 C CG . TRP B 1 1 ? 56.350 -36.520 -1.984 1.00 13.50 ? 21 TRP B CG 1 ATOM 2095 C CD1 . TRP B 1 1 ? 55.506 -37.579 -1.844 1.00 14.34 ? 21 TRP B CD1 1 ATOM 2096 C CD2 . TRP B 1 1 ? 55.599 -35.503 -2.661 1.00 13.01 ? 21 TRP B CD2 1 ATOM 2097 N NE1 . TRP B 1 1 ? 54.228 -37.253 -2.326 1.00 12.88 ? 21 TRP B NE1 1 ATOM 2098 C CE2 . TRP B 1 1 ? 54.296 -36.003 -2.871 1.00 13.27 ? 21 TRP B CE2 1 ATOM 2099 C CE3 . TRP B 1 1 ? 55.923 -34.222 -3.148 1.00 14.30 ? 21 TRP B CE3 1 ATOM 2100 C CZ2 . TRP B 1 1 ? 53.274 -35.231 -3.448 1.00 13.74 ? 21 TRP B CZ2 1 ATOM 2101 C CZ3 . TRP B 1 1 ? 54.935 -33.468 -3.747 1.00 13.94 ? 21 TRP B CZ3 1 ATOM 2102 C CH2 . TRP B 1 1 ? 53.607 -34.001 -3.916 1.00 14.07 ? 21 TRP B CH2 1 ATOM 2103 N N . GLY B 1 2 ? 60.732 -35.657 -1.840 1.00 15.19 ? 22 GLY B N 1 ATOM 2104 C CA . GLY B 1 2 ? 61.928 -35.572 -0.987 1.00 15.00 ? 22 GLY B CA 1 ATOM 2105 C C . GLY B 1 2 ? 61.553 -35.881 0.447 1.00 15.32 ? 22 GLY B C 1 ATOM 2106 O O . GLY B 1 2 ? 60.397 -36.260 0.754 1.00 14.94 ? 22 GLY B O 1 ATOM 2107 N N . ASN B 1 3 ? 62.505 -35.674 1.335 1.00 14.45 ? 23 ASN B N 1 ATOM 2108 C CA . ASN B 1 3 ? 62.296 -36.032 2.752 1.00 17.11 ? 23 ASN B CA 1 ATOM 2109 C C . ASN B 1 3 ? 61.106 -35.331 3.415 1.00 15.04 ? 23 ASN B C 1 ATOM 2110 O O . ASN B 1 3 ? 60.316 -35.948 4.113 1.00 16.02 ? 23 ASN B O 1 ATOM 2111 C CB . ASN B 1 3 ? 63.576 -35.718 3.572 1.00 18.25 ? 23 ASN B CB 1 ATOM 2112 C CG . ASN B 1 3 ? 64.758 -36.568 3.122 1.00 21.28 ? 23 ASN B CG 1 ATOM 2113 O OD1 . ASN B 1 3 ? 64.565 -37.653 2.653 1.00 21.33 ? 23 ASN B OD1 1 ATOM 2114 N ND2 . ASN B 1 3 ? 65.977 -36.051 3.246 1.00 24.29 ? 23 ASN B ND2 1 ATOM 2115 N N . LEU B 1 4 ? 61.029 -34.044 3.220 1.00 14.77 ? 24 LEU B N 1 ATOM 2116 C CA . LEU B 1 4 ? 59.948 -33.241 3.811 1.00 15.37 ? 24 LEU B CA 1 ATOM 2117 C C . LEU B 1 4 ? 58.569 -33.804 3.422 1.00 15.21 ? 24 LEU B C 1 ATOM 2118 O O . LEU B 1 4 ? 57.702 -34.002 4.282 1.00 13.17 ? 24 LEU B O 1 ATOM 2119 C CB . LEU B 1 4 ? 60.129 -31.794 3.379 1.00 17.27 ? 24 LEU B CB 1 ATOM 2120 C CG . LEU B 1 4 ? 59.116 -30.675 3.749 1.00 18.96 ? 24 LEU B CG 1 ATOM 2121 C CD1 . LEU B 1 4 ? 57.830 -30.700 2.989 1.00 19.11 ? 24 LEU B CD1 1 ATOM 2122 C CD2 . LEU B 1 4 ? 58.901 -30.617 5.234 1.00 20.27 ? 24 LEU B CD2 1 ATOM 2123 N N . GLY B 1 5 ? 58.368 -34.043 2.121 1.00 14.37 ? 25 GLY B N 1 ATOM 2124 C CA . GLY B 1 5 ? 57.067 -34.585 1.648 1.00 13.92 ? 25 GLY B CA 1 ATOM 2125 C C . GLY B 1 5 ? 56.709 -35.900 2.283 1.00 12.80 ? 25 GLY B C 1 ATOM 2126 O O . GLY B 1 5 ? 55.615 -36.056 2.805 1.00 14.04 ? 25 GLY B O 1 ATOM 2127 N N . HIS B 1 6 ? 57.664 -36.832 2.313 1.00 11.89 ? 26 HIS B N 1 ATOM 2128 C CA . HIS B 1 6 ? 57.410 -38.109 2.918 1.00 11.51 ? 26 HIS B CA 1 ATOM 2129 C C . HIS B 1 6 ? 57.098 -38.037 4.406 1.00 12.01 ? 26 HIS B C 1 ATOM 2130 O O . HIS B 1 6 ? 56.218 -38.771 4.897 1.00 11.84 ? 26 HIS B O 1 ATOM 2131 C CB . HIS B 1 6 ? 58.555 -39.094 2.691 1.00 12.62 ? 26 HIS B CB 1 ATOM 2132 C CG . HIS B 1 6 ? 58.615 -39.582 1.304 1.00 13.34 ? 26 HIS B CG 1 ATOM 2133 N ND1 . HIS B 1 6 ? 57.655 -40.430 0.814 1.00 13.14 ? 26 HIS B ND1 1 ATOM 2134 C CD2 . HIS B 1 6 ? 59.407 -39.239 0.252 1.00 14.45 ? 26 HIS B CD2 1 ATOM 2135 C CE1 . HIS B 1 6 ? 57.891 -40.641 -0.471 1.00 13.91 ? 26 HIS B CE1 1 ATOM 2136 N NE2 . HIS B 1 6 ? 58.917 -39.906 -0.847 1.00 13.70 ? 26 HIS B NE2 1 ATOM 2137 N N . GLU B 1 7 ? 57.846 -37.200 5.116 1.00 11.49 ? 27 GLU B N 1 ATOM 2138 C CA . GLU B 1 7 ? 57.657 -37.081 6.569 1.00 13.31 ? 27 GLU B CA 1 ATOM 2139 C C . GLU B 1 7 ? 56.297 -36.409 6.876 1.00 12.35 ? 27 GLU B C 1 ATOM 2140 O O . GLU B 1 7 ? 55.610 -36.778 7.832 1.00 11.28 ? 27 GLU B O 1 ATOM 2141 C CB . GLU B 1 7 ? 58.805 -36.302 7.180 1.00 13.80 ? 27 GLU B CB 1 ATOM 2142 C CG . GLU B 1 7 ? 60.101 -37.089 7.168 1.00 15.34 ? 27 GLU B CG 1 ATOM 2143 C CD . GLU B 1 7 ? 61.342 -36.228 7.240 1.00 18.04 ? 27 GLU B CD 1 ATOM 2144 O OE1 . GLU B 1 7 ? 61.279 -34.962 7.246 1.00 16.78 ? 27 GLU B OE1 1 ATOM 2145 O OE2 . GLU B 1 7 ? 62.425 -36.846 7.238 1.00 20.64 ? 27 GLU B OE2 1 ATOM 2146 N N . THR B 1 8 ? 55.944 -35.429 6.042 1.00 12.12 ? 28 THR B N 1 ATOM 2147 C CA . THR B 1 8 ? 54.633 -34.800 6.109 1.00 13.62 ? 28 THR B CA 1 ATOM 2148 C C . THR B 1 8 ? 53.472 -35.802 5.906 1.00 12.97 ? 28 THR B C 1 ATOM 2149 O O . THR B 1 8 ? 52.558 -35.874 6.719 1.00 13.83 ? 28 THR B O 1 ATOM 2150 C CB . THR B 1 8 ? 54.486 -33.662 5.114 1.00 12.63 ? 28 THR B CB 1 ATOM 2151 O OG1 . THR B 1 8 ? 55.513 -32.701 5.334 1.00 12.06 ? 28 THR B OG1 1 ATOM 2152 C CG2 . THR B 1 8 ? 53.125 -32.989 5.274 1.00 13.67 ? 28 THR B CG2 1 ATOM 2153 N N . VAL B 1 9 ? 53.580 -36.620 4.866 1.00 13.01 ? 29 VAL B N 1 ATOM 2154 C CA . VAL B 1 9 ? 52.587 -37.674 4.611 1.00 13.03 ? 29 VAL B CA 1 ATOM 2155 C C . VAL B 1 9 ? 52.462 -38.603 5.853 1.00 13.22 ? 29 VAL B C 1 ATOM 2156 O O . VAL B 1 9 ? 51.354 -38.900 6.323 1.00 12.99 ? 29 VAL B O 1 ATOM 2157 C CB . VAL B 1 9 ? 52.948 -38.486 3.361 1.00 13.52 ? 29 VAL B CB 1 ATOM 2158 C CG1 . VAL B 1 9 ? 52.153 -39.772 3.233 1.00 13.01 ? 29 VAL B CG1 1 ATOM 2159 C CG2 . VAL B 1 9 ? 52.747 -37.644 2.132 1.00 14.54 ? 29 VAL B CG2 1 ATOM 2160 N N . ALA B 1 10 ? 53.599 -39.027 6.372 1.00 13.32 ? 30 ALA B N 1 ATOM 2161 C CA . ALA B 1 10 ? 53.610 -39.947 7.493 1.00 13.70 ? 30 ALA B CA 1 ATOM 2162 C C . ALA B 1 10 ? 52.954 -39.293 8.756 1.00 14.80 ? 30 ALA B C 1 ATOM 2163 O O . ALA B 1 10 ? 52.228 -39.989 9.508 1.00 16.51 ? 30 ALA B O 1 ATOM 2164 C CB . ALA B 1 10 ? 55.031 -40.405 7.809 1.00 13.62 ? 30 ALA B CB 1 ATOM 2165 N N . TYR B 1 11 ? 53.286 -38.036 9.031 1.00 14.39 ? 31 TYR B N 1 ATOM 2166 C CA . TYR B 1 11 ? 52.731 -37.377 10.245 1.00 15.53 ? 31 TYR B CA 1 ATOM 2167 C C . TYR B 1 11 ? 51.193 -37.197 10.108 1.00 16.21 ? 31 TYR B C 1 ATOM 2168 O O . TYR B 1 11 ? 50.442 -37.377 11.058 1.00 16.36 ? 31 TYR B O 1 ATOM 2169 C CB . TYR B 1 11 ? 53.384 -36.046 10.492 1.00 15.23 ? 31 TYR B CB 1 ATOM 2170 C CG . TYR B 1 11 ? 54.685 -36.098 11.279 1.00 14.65 ? 31 TYR B CG 1 ATOM 2171 C CD1 . TYR B 1 11 ? 54.759 -36.722 12.536 1.00 15.15 ? 31 TYR B CD1 1 ATOM 2172 C CD2 . TYR B 1 11 ? 55.809 -35.407 10.817 1.00 14.60 ? 31 TYR B CD2 1 ATOM 2173 C CE1 . TYR B 1 11 ? 55.976 -36.747 13.257 1.00 14.91 ? 31 TYR B CE1 1 ATOM 2174 C CE2 . TYR B 1 11 ? 56.999 -35.373 11.553 1.00 14.98 ? 31 TYR B CE2 1 ATOM 2175 C CZ . TYR B 1 11 ? 57.070 -36.041 12.783 1.00 15.87 ? 31 TYR B CZ 1 ATOM 2176 O OH . TYR B 1 11 ? 58.232 -35.959 13.502 1.00 17.26 ? 31 TYR B OH 1 ATOM 2177 N N . ILE B 1 12 ? 50.737 -36.913 8.903 1.00 15.47 ? 32 ILE B N 1 ATOM 2178 C CA . ILE B 1 12 ? 49.287 -36.886 8.663 1.00 16.34 ? 32 ILE B CA 1 ATOM 2179 C C . ILE B 1 12 ? 48.667 -38.245 8.991 1.00 15.18 ? 32 ILE B C 1 ATOM 2180 O O . ILE B 1 12 ? 47.657 -38.341 9.695 1.00 16.52 ? 32 ILE B O 1 ATOM 2181 C CB . ILE B 1 12 ? 48.930 -36.422 7.212 1.00 15.29 ? 32 ILE B CB 1 ATOM 2182 C CG1 . ILE B 1 12 ? 49.428 -34.994 7.000 1.00 15.46 ? 32 ILE B CG1 1 ATOM 2183 C CG2 . ILE B 1 12 ? 47.424 -36.505 6.976 1.00 14.61 ? 32 ILE B CG2 1 ATOM 2184 C CD1 . ILE B 1 12 ? 49.443 -34.499 5.565 1.00 16.50 ? 32 ILE B CD1 1 ATOM 2185 N N . ALA B 1 13 ? 49.230 -39.297 8.442 1.00 15.48 ? 33 ALA B N 1 ATOM 2186 C CA . ALA B 1 13 ? 48.714 -40.619 8.679 1.00 14.88 ? 33 ALA B CA 1 ATOM 2187 C C . ALA B 1 13 ? 48.654 -40.906 10.175 1.00 15.56 ? 33 ALA B C 1 ATOM 2188 O O . ALA B 1 13 ? 47.652 -41.447 10.653 1.00 14.38 ? 33 ALA B O 1 ATOM 2189 C CB . ALA B 1 13 ? 49.502 -41.704 7.961 1.00 14.91 ? 33 ALA B CB 1 ATOM 2190 N N . GLN B 1 14 ? 49.715 -40.548 10.905 1.00 16.23 ? 34 GLN B N 1 ATOM 2191 C CA . GLN B 1 14 ? 49.719 -40.778 12.360 1.00 18.00 ? 34 GLN B CA 1 ATOM 2192 C C . GLN B 1 14 ? 48.546 -40.069 13.039 1.00 18.61 ? 34 GLN B C 1 ATOM 2193 O O . GLN B 1 14 ? 48.008 -40.594 14.022 1.00 21.11 ? 34 GLN B O 1 ATOM 2194 C CB . GLN B 1 14 ? 51.010 -40.319 13.033 1.00 19.45 ? 34 GLN B CB 1 ATOM 2195 C CG . GLN B 1 14 ? 52.282 -41.077 12.638 1.00 18.89 ? 34 GLN B CG 1 ATOM 2196 C CD . GLN B 1 14 ? 53.560 -40.501 13.262 1.00 20.38 ? 34 GLN B CD 1 ATOM 2197 O OE1 . GLN B 1 14 ? 54.664 -40.859 12.851 1.00 18.65 ? 34 GLN B OE1 1 ATOM 2198 N NE2 . GLN B 1 14 ? 53.421 -39.676 14.303 1.00 19.34 ? 34 GLN B NE2 1 ATOM 2199 N N . SER B 1 15 ? 48.151 -38.910 12.527 1.00 16.91 ? 35 SER B N 1 ATOM 2200 C CA . SER B 1 15 ? 47.004 -38.188 13.075 1.00 19.18 ? 35 SER B CA 1 ATOM 2201 C C . SER B 1 15 ? 45.639 -38.851 12.823 1.00 20.36 ? 35 SER B C 1 ATOM 2202 O O . SER B 1 15 ? 44.681 -38.469 13.468 1.00 20.24 ? 35 SER B O 1 ATOM 2203 C CB . SER B 1 15 ? 46.938 -36.729 12.608 1.00 17.98 ? 35 SER B CB 1 ATOM 2204 O OG . SER B 1 15 ? 48.070 -35.997 12.995 1.00 18.27 ? 35 SER B OG 1 ATOM 2205 N N . PHE B 1 16 ? 45.539 -39.803 11.883 1.00 17.95 ? 36 PHE B N 1 ATOM 2206 C CA . PHE B 1 16 ? 44.243 -40.376 11.532 1.00 18.29 ? 36 PHE B CA 1 ATOM 2207 C C . PHE B 1 16 ? 44.072 -41.825 11.841 1.00 19.13 ? 36 PHE B C 1 ATOM 2208 O O . PHE B 1 16 ? 42.940 -42.300 11.830 1.00 22.93 ? 36 PHE B O 1 ATOM 2209 C CB . PHE B 1 16 ? 43.888 -40.119 10.035 1.00 17.82 ? 36 PHE B CB 1 ATOM 2210 C CG . PHE B 1 16 ? 43.557 -38.714 9.754 1.00 16.76 ? 36 PHE B CG 1 ATOM 2211 C CD1 . PHE B 1 16 ? 42.282 -38.233 10.037 1.00 17.88 ? 36 PHE B CD1 1 ATOM 2212 C CD2 . PHE B 1 16 ? 44.534 -37.812 9.344 1.00 17.04 ? 36 PHE B CD2 1 ATOM 2213 C CE1 . PHE B 1 16 ? 41.986 -36.893 9.853 1.00 17.07 ? 36 PHE B CE1 1 ATOM 2214 C CE2 . PHE B 1 16 ? 44.243 -36.474 9.129 1.00 17.17 ? 36 PHE B CE2 1 ATOM 2215 C CZ . PHE B 1 16 ? 42.940 -36.012 9.377 1.00 19.26 ? 36 PHE B CZ 1 ATOM 2216 N N . VAL B 1 17 ? 45.156 -42.554 12.079 1.00 18.30 ? 37 VAL B N 1 ATOM 2217 C CA . VAL B 1 17 ? 45.006 -43.975 12.319 1.00 19.48 ? 37 VAL B CA 1 ATOM 2218 C C . VAL B 1 17 ? 44.321 -44.176 13.708 1.00 21.46 ? 37 VAL B C 1 ATOM 2219 O O . VAL B 1 17 ? 44.424 -43.302 14.586 1.00 19.88 ? 37 VAL B O 1 ATOM 2220 C CB . VAL B 1 17 ? 46.350 -44.760 12.328 1.00 19.82 ? 37 VAL B CB 1 ATOM 2221 C CG1 . VAL B 1 17 ? 46.966 -44.788 10.944 1.00 19.49 ? 37 VAL B CG1 1 ATOM 2222 C CG2 . VAL B 1 17 ? 47.349 -44.249 13.384 1.00 19.74 ? 37 VAL B CG2 1 ATOM 2223 N N . ALA B 1 18 ? 43.684 -45.317 13.865 1.00 22.64 ? 38 ALA B N 1 ATOM 2224 C CA . ALA B 1 18 ? 43.134 -45.752 15.163 1.00 26.33 ? 38 ALA B CA 1 ATOM 2225 C C . ALA B 1 18 ? 44.260 -46.121 16.130 1.00 26.33 ? 38 ALA B C 1 ATOM 2226 O O . ALA B 1 18 ? 45.404 -46.446 15.706 1.00 25.69 ? 38 ALA B O 1 ATOM 2227 C CB . ALA B 1 18 ? 42.218 -46.964 14.955 1.00 26.20 ? 38 ALA B CB 1 ATOM 2228 N N . SER B 1 19 ? 43.940 -46.120 17.426 1.00 26.40 ? 39 SER B N 1 ATOM 2229 C CA . SER B 1 19 ? 44.953 -46.423 18.459 1.00 27.50 ? 39 SER B CA 1 ATOM 2230 C C . SER B 1 19 ? 45.489 -47.805 18.301 1.00 25.14 ? 39 SER B C 1 ATOM 2231 O O . SER B 1 19 ? 46.694 -48.024 18.470 1.00 25.26 ? 39 SER B O 1 ATOM 2232 C CB A SER B 1 19 ? 44.394 -46.218 19.880 0.50 30.19 ? 39 SER B CB 1 ATOM 2233 C CB B SER B 1 19 ? 44.398 -46.268 19.910 0.50 28.02 ? 39 SER B CB 1 ATOM 2234 O OG A SER B 1 19 ? 43.272 -47.037 20.078 0.50 31.57 ? 39 SER B OG 1 ATOM 2235 O OG B SER B 1 19 ? 43.767 -45.014 20.122 0.50 25.54 ? 39 SER B OG 1 ATOM 2236 N N . SER B 1 20 ? 44.628 -48.757 17.941 1.00 25.32 ? 40 SER B N 1 ATOM 2237 C CA . SER B 1 20 ? 45.101 -50.125 17.758 1.00 25.59 ? 40 SER B CA 1 ATOM 2238 C C . SER B 1 20 ? 46.019 -50.279 16.530 1.00 24.04 ? 40 SER B C 1 ATOM 2239 O O . SER B 1 20 ? 46.921 -51.138 16.507 1.00 26.73 ? 40 SER B O 1 ATOM 2240 C CB . SER B 1 20 ? 43.926 -51.091 17.630 1.00 31.25 ? 40 SER B CB 1 ATOM 2241 O OG . SER B 1 20 ? 43.066 -50.641 16.614 1.00 33.17 ? 40 SER B OG 1 ATOM 2242 N N . THR B 1 21 ? 45.784 -49.447 15.510 1.00 21.88 ? 41 THR B N 1 ATOM 2243 C CA . THR B 1 21 ? 46.668 -49.391 14.321 1.00 21.99 ? 41 THR B CA 1 ATOM 2244 C C . THR B 1 21 ? 48.062 -48.836 14.715 1.00 20.30 ? 41 THR B C 1 ATOM 2245 O O . THR B 1 21 ? 49.089 -49.368 14.331 1.00 20.47 ? 41 THR B O 1 ATOM 2246 C CB . THR B 1 21 ? 46.034 -48.516 13.208 1.00 20.88 ? 41 THR B CB 1 ATOM 2247 O OG1 . THR B 1 21 ? 44.750 -49.076 12.853 1.00 21.75 ? 41 THR B OG1 1 ATOM 2248 C CG2 . THR B 1 21 ? 46.941 -48.471 11.926 1.00 19.40 ? 41 THR B CG2 1 ATOM 2249 N N . GLU B 1 22 ? 48.034 -47.763 15.479 1.00 22.16 ? 42 GLU B N 1 ATOM 2250 C CA . GLU B 1 22 ? 49.240 -47.160 16.007 1.00 24.74 ? 42 GLU B CA 1 ATOM 2251 C C . GLU B 1 22 ? 50.090 -48.217 16.715 1.00 26.18 ? 42 GLU B C 1 ATOM 2252 O O . GLU B 1 22 ? 51.261 -48.335 16.415 1.00 23.42 ? 42 GLU B O 1 ATOM 2253 C CB . GLU B 1 22 ? 48.902 -45.994 16.910 1.00 26.43 ? 42 GLU B CB 1 ATOM 2254 C CG . GLU B 1 22 ? 50.107 -45.448 17.671 1.00 30.57 ? 42 GLU B CG 1 ATOM 2255 C CD . GLU B 1 22 ? 49.780 -44.226 18.536 1.00 35.94 ? 42 GLU B CD 1 ATOM 2256 O OE1 . GLU B 1 22 ? 48.656 -43.761 18.581 1.00 39.30 ? 42 GLU B OE1 1 ATOM 2257 O OE2 . GLU B 1 22 ? 50.666 -43.693 19.192 1.00 43.42 ? 42 GLU B OE2 1 ATOM 2258 N N . SER B 1 23 ? 49.485 -48.994 17.627 1.00 26.45 ? 43 SER B N 1 ATOM 2259 C CA . SER B 1 23 ? 50.237 -50.016 18.368 1.00 27.01 ? 43 SER B CA 1 ATOM 2260 C C . SER B 1 23 ? 50.771 -51.053 17.457 1.00 25.37 ? 43 SER B C 1 ATOM 2261 O O . SER B 1 23 ? 51.890 -51.475 17.623 1.00 28.81 ? 43 SER B O 1 ATOM 2262 C CB . SER B 1 23 ? 49.383 -50.733 19.447 1.00 29.46 ? 43 SER B CB 1 ATOM 2263 O OG . SER B 1 23 ? 48.820 -49.757 20.289 1.00 32.06 ? 43 SER B OG 1 ATOM 2264 N N . PHE B 1 24 ? 49.921 -51.539 16.560 1.00 25.05 ? 44 PHE B N 1 ATOM 2265 C CA . PHE B 1 24 ? 50.317 -52.511 15.552 1.00 25.18 ? 44 PHE B CA 1 ATOM 2266 C C . PHE B 1 24 ? 51.621 -52.082 14.771 1.00 26.25 ? 44 PHE B C 1 ATOM 2267 O O . PHE B 1 24 ? 52.579 -52.873 14.610 1.00 24.41 ? 44 PHE B O 1 ATOM 2268 C CB . PHE B 1 24 ? 49.124 -52.722 14.593 1.00 26.67 ? 44 PHE B CB 1 ATOM 2269 C CG . PHE B 1 24 ? 49.411 -53.623 13.416 1.00 27.59 ? 44 PHE B CG 1 ATOM 2270 C CD1 . PHE B 1 24 ? 49.270 -54.991 13.522 1.00 25.59 ? 44 PHE B CD1 1 ATOM 2271 C CD2 . PHE B 1 24 ? 49.788 -53.080 12.169 1.00 26.57 ? 44 PHE B CD2 1 ATOM 2272 C CE1 . PHE B 1 24 ? 49.498 -55.814 12.439 1.00 26.45 ? 44 PHE B CE1 1 ATOM 2273 C CE2 . PHE B 1 24 ? 50.054 -53.902 11.090 1.00 27.26 ? 44 PHE B CE2 1 ATOM 2274 C CZ . PHE B 1 24 ? 49.905 -55.272 11.211 1.00 27.86 ? 44 PHE B CZ 1 ATOM 2275 N N . CYS B 1 25 ? 51.635 -50.828 14.286 1.00 24.13 ? 45 CYS B N 1 ATOM 2276 C CA . CYS B 1 25 ? 52.807 -50.262 13.590 1.00 23.33 ? 45 CYS B CA 1 ATOM 2277 C C . CYS B 1 25 ? 54.017 -50.074 14.503 1.00 21.50 ? 45 CYS B C 1 ATOM 2278 O O . CYS B 1 25 ? 55.109 -50.473 14.172 1.00 19.59 ? 45 CYS B O 1 ATOM 2279 C CB . CYS B 1 25 ? 52.423 -48.916 12.929 1.00 22.16 ? 45 CYS B CB 1 ATOM 2280 S SG . CYS B 1 25 ? 51.178 -49.099 11.612 1.00 21.74 ? 45 CYS B SG 1 ATOM 2281 N N . GLN B 1 26 ? 53.793 -49.467 15.666 1.00 24.46 ? 46 GLN B N 1 ATOM 2282 C CA . GLN B 1 26 ? 54.887 -49.272 16.658 1.00 27.84 ? 46 GLN B CA 1 ATOM 2283 C C . GLN B 1 26 ? 55.571 -50.608 16.996 1.00 27.56 ? 46 GLN B C 1 ATOM 2284 O O . GLN B 1 26 ? 56.795 -50.672 17.009 1.00 27.66 ? 46 GLN B O 1 ATOM 2285 C CB . GLN B 1 26 ? 54.416 -48.556 17.913 1.00 26.38 ? 46 GLN B CB 1 ATOM 2286 C CG . GLN B 1 26 ? 54.093 -47.093 17.644 1.00 29.17 ? 46 GLN B CG 1 ATOM 2287 C CD . GLN B 1 26 ? 53.473 -46.359 18.838 1.00 30.36 ? 46 GLN B CD 1 ATOM 2288 O OE1 . GLN B 1 26 ? 52.863 -46.969 19.695 1.00 29.14 ? 46 GLN B OE1 1 ATOM 2289 N NE2 . GLN B 1 26 ? 53.586 -45.038 18.853 1.00 32.41 ? 46 GLN B NE2 1 ATOM 2290 N N . ASN B 1 27 ? 54.779 -51.671 17.172 1.00 28.70 ? 47 ASN B N 1 ATOM 2291 C CA . ASN B 1 27 ? 55.329 -53.007 17.455 1.00 30.67 ? 47 ASN B CA 1 ATOM 2292 C C . ASN B 1 27 ? 56.165 -53.537 16.307 1.00 30.38 ? 47 ASN B C 1 ATOM 2293 O O . ASN B 1 27 ? 57.296 -54.005 16.516 1.00 30.19 ? 47 ASN B O 1 ATOM 2294 C CB A ASN B 1 27 ? 54.239 -54.056 17.781 0.50 31.18 ? 47 ASN B CB 1 ATOM 2295 C CB B ASN B 1 27 ? 54.209 -53.973 17.881 0.50 31.48 ? 47 ASN B CB 1 ATOM 2296 C CG A ASN B 1 27 ? 54.786 -55.494 17.843 0.50 31.85 ? 47 ASN B CG 1 ATOM 2297 C CG B ASN B 1 27 ? 53.644 -53.655 19.270 0.50 32.14 ? 47 ASN B CG 1 ATOM 2298 O OD1 A ASN B 1 27 ? 54.442 -56.351 17.030 0.50 29.97 ? 47 ASN B OD1 1 ATOM 2299 O OD1 B ASN B 1 27 ? 54.077 -52.724 19.962 0.50 32.89 ? 47 ASN B OD1 1 ATOM 2300 N ND2 A ASN B 1 27 ? 55.672 -55.740 18.790 0.50 32.98 ? 47 ASN B ND2 1 ATOM 2301 N ND2 B ASN B 1 27 ? 52.645 -54.422 19.671 0.50 34.22 ? 47 ASN B ND2 1 ATOM 2302 N N . ILE B 1 28 ? 55.651 -53.429 15.082 1.00 28.54 ? 48 ILE B N 1 ATOM 2303 C CA . ILE B 1 28 ? 56.431 -53.890 13.906 1.00 28.01 ? 48 ILE B CA 1 ATOM 2304 C C . ILE B 1 28 ? 57.758 -53.123 13.717 1.00 28.47 ? 48 ILE B C 1 ATOM 2305 O O . ILE B 1 28 ? 58.784 -53.700 13.321 1.00 30.06 ? 48 ILE B O 1 ATOM 2306 C CB . ILE B 1 28 ? 55.585 -53.848 12.606 1.00 29.45 ? 48 ILE B CB 1 ATOM 2307 C CG1 . ILE B 1 28 ? 54.587 -55.010 12.637 1.00 29.16 ? 48 ILE B CG1 1 ATOM 2308 C CG2 . ILE B 1 28 ? 56.453 -53.958 11.327 1.00 28.91 ? 48 ILE B CG2 1 ATOM 2309 C CD1 . ILE B 1 28 ? 53.373 -54.842 11.755 1.00 28.67 ? 48 ILE B CD1 1 ATOM 2310 N N . LEU B 1 29 ? 57.684 -51.807 13.920 1.00 28.15 ? 49 LEU B N 1 ATOM 2311 C CA . LEU B 1 29 ? 58.812 -50.905 13.695 1.00 28.27 ? 49 LEU B CA 1 ATOM 2312 C C . LEU B 1 29 ? 59.781 -50.836 14.864 1.00 31.05 ? 49 LEU B C 1 ATOM 2313 O O . LEU B 1 29 ? 60.887 -50.350 14.692 1.00 29.54 ? 49 LEU B O 1 ATOM 2314 C CB . LEU B 1 29 ? 58.319 -49.470 13.416 1.00 28.80 ? 49 LEU B CB 1 ATOM 2315 C CG . LEU B 1 29 ? 57.467 -49.288 12.136 1.00 26.93 ? 49 LEU B CG 1 ATOM 2316 C CD1 . LEU B 1 29 ? 56.892 -47.898 12.106 1.00 26.54 ? 49 LEU B CD1 1 ATOM 2317 C CD2 . LEU B 1 29 ? 58.273 -49.585 10.875 1.00 28.02 ? 49 LEU B CD2 1 ATOM 2318 N N . GLY B 1 30 ? 59.362 -51.314 16.044 1.00 32.75 ? 50 GLY B N 1 ATOM 2319 C CA . GLY B 1 30 ? 60.160 -51.189 17.282 1.00 32.40 ? 50 GLY B CA 1 ATOM 2320 C C . GLY B 1 30 ? 60.408 -49.750 17.686 1.00 33.72 ? 50 GLY B C 1 ATOM 2321 O O . GLY B 1 30 ? 61.500 -49.389 18.094 1.00 36.11 ? 50 GLY B O 1 ATOM 2322 N N . ASP B 1 31 ? 59.406 -48.910 17.512 1.00 30.89 ? 51 ASP B N 1 ATOM 2323 C CA . ASP B 1 31 ? 59.573 -47.485 17.698 1.00 32.81 ? 51 ASP B CA 1 ATOM 2324 C C . ASP B 1 31 ? 58.254 -47.014 18.234 1.00 36.24 ? 51 ASP B C 1 ATOM 2325 O O . ASP B 1 31 ? 57.256 -47.014 17.511 1.00 31.52 ? 51 ASP B O 1 ATOM 2326 C CB . ASP B 1 31 ? 59.918 -46.802 16.335 1.00 31.86 ? 51 ASP B CB 1 ATOM 2327 C CG . ASP B 1 31 ? 60.039 -45.227 16.402 1.00 32.31 ? 51 ASP B CG 1 ATOM 2328 O OD1 . ASP B 1 31 ? 59.566 -44.567 17.351 1.00 32.53 ? 51 ASP B OD1 1 ATOM 2329 O OD2 . ASP B 1 31 ? 60.623 -44.628 15.445 1.00 32.20 ? 51 ASP B OD2 1 ATOM 2330 N N . ASP B 1 32 ? 58.231 -46.589 19.477 1.00 36.15 ? 52 ASP B N 1 ATOM 2331 C CA A ASP B 1 32 ? 56.981 -46.094 20.028 0.50 36.84 ? 52 ASP B CA 1 ATOM 2332 C CA B ASP B 1 32 ? 56.990 -46.111 20.061 0.50 38.42 ? 52 ASP B CA 1 ATOM 2333 C C . ASP B 1 32 ? 57.011 -44.586 20.283 1.00 36.87 ? 52 ASP B C 1 ATOM 2334 O O . ASP B 1 32 ? 56.243 -44.066 21.048 1.00 34.86 ? 52 ASP B O 1 ATOM 2335 C CB A ASP B 1 32 ? 56.536 -46.903 21.237 0.50 40.27 ? 52 ASP B CB 1 ATOM 2336 C CB B ASP B 1 32 ? 56.647 -46.927 21.311 0.50 44.05 ? 52 ASP B CB 1 ATOM 2337 C CG A ASP B 1 32 ? 57.376 -46.639 22.459 0.50 42.67 ? 52 ASP B CG 1 ATOM 2338 C CG B ASP B 1 32 ? 57.817 -47.044 22.268 0.50 49.84 ? 52 ASP B CG 1 ATOM 2339 O OD1 A ASP B 1 32 ? 58.468 -46.044 22.305 0.50 46.66 ? 52 ASP B OD1 1 ATOM 2340 O OD1 B ASP B 1 32 ? 58.037 -46.062 23.014 0.50 53.44 ? 52 ASP B OD1 1 ATOM 2341 O OD2 A ASP B 1 32 ? 56.927 -47.005 23.570 0.50 42.80 ? 52 ASP B OD2 1 ATOM 2342 O OD2 B ASP B 1 32 ? 58.529 -48.089 22.241 0.50 51.47 ? 52 ASP B OD2 1 ATOM 2343 N N . SER B 1 33 ? 57.874 -43.865 19.572 1.00 32.63 ? 53 SER B N 1 ATOM 2344 C CA . SER B 1 33 ? 57.835 -42.387 19.652 1.00 28.94 ? 53 SER B CA 1 ATOM 2345 C C . SER B 1 33 ? 56.606 -41.808 18.971 1.00 26.18 ? 53 SER B C 1 ATOM 2346 O O . SER B 1 33 ? 55.886 -42.502 18.268 1.00 29.35 ? 53 SER B O 1 ATOM 2347 C CB . SER B 1 33 ? 59.091 -41.760 19.022 1.00 31.32 ? 53 SER B CB 1 ATOM 2348 O OG . SER B 1 33 ? 59.112 -41.932 17.610 1.00 29.55 ? 53 SER B OG 1 ATOM 2349 N N . THR B 1 34 ? 56.408 -40.525 19.167 1.00 25.18 ? 54 THR B N 1 ATOM 2350 C CA . THR B 1 34 ? 55.411 -39.810 18.489 1.00 29.54 ? 54 THR B CA 1 ATOM 2351 C C . THR B 1 34 ? 55.837 -39.520 17.000 1.00 27.29 ? 54 THR B C 1 ATOM 2352 O O . THR B 1 34 ? 55.224 -38.686 16.371 1.00 24.72 ? 54 THR B O 1 ATOM 2353 C CB . THR B 1 34 ? 55.071 -38.501 19.246 1.00 35.02 ? 54 THR B CB 1 ATOM 2354 O OG1 . THR B 1 34 ? 56.256 -37.732 19.445 1.00 37.22 ? 54 THR B OG1 1 ATOM 2355 C CG2 . THR B 1 34 ? 54.470 -38.811 20.620 1.00 37.62 ? 54 THR B CG2 1 ATOM 2356 N N . SER B 1 35 ? 56.932 -40.125 16.501 1.00 23.08 ? 55 SER B N 1 ATOM 2357 C CA . SER B 1 35 ? 57.362 -39.957 15.114 1.00 21.22 ? 55 SER B CA 1 ATOM 2358 C C . SER B 1 35 ? 57.500 -41.280 14.410 1.00 19.91 ? 55 SER B C 1 ATOM 2359 O O . SER B 1 35 ? 58.165 -41.377 13.370 1.00 19.07 ? 55 SER B O 1 ATOM 2360 C CB . SER B 1 35 ? 58.690 -39.185 15.029 1.00 22.22 ? 55 SER B CB 1 ATOM 2361 O OG . SER B 1 35 ? 58.535 -37.845 15.385 1.00 21.69 ? 55 SER B OG 1 ATOM 2362 N N . TYR B 1 36 ? 56.885 -42.300 14.971 1.00 17.93 ? 56 TYR B N 1 ATOM 2363 C CA . TYR B 1 36 ? 57.121 -43.676 14.522 1.00 18.35 ? 56 TYR B CA 1 ATOM 2364 C C . TYR B 1 36 ? 57.010 -43.903 12.972 1.00 19.41 ? 56 TYR B C 1 ATOM 2365 O O . TYR B 1 36 ? 57.887 -44.480 12.365 1.00 17.78 ? 56 TYR B O 1 ATOM 2366 C CB . TYR B 1 36 ? 56.252 -44.637 15.323 1.00 19.44 ? 56 TYR B CB 1 ATOM 2367 C CG . TYR B 1 36 ? 54.742 -44.548 15.088 1.00 18.63 ? 56 TYR B CG 1 ATOM 2368 C CD1 . TYR B 1 36 ? 53.965 -43.557 15.683 1.00 19.00 ? 56 TYR B CD1 1 ATOM 2369 C CD2 . TYR B 1 36 ? 54.098 -45.479 14.284 1.00 19.34 ? 56 TYR B CD2 1 ATOM 2370 C CE1 . TYR B 1 36 ? 52.581 -43.476 15.466 1.00 19.08 ? 56 TYR B CE1 1 ATOM 2371 C CE2 . TYR B 1 36 ? 52.727 -45.404 14.065 1.00 19.24 ? 56 TYR B CE2 1 ATOM 2372 C CZ . TYR B 1 36 ? 51.986 -44.399 14.650 1.00 18.61 ? 56 TYR B CZ 1 ATOM 2373 O OH . TYR B 1 36 ? 50.629 -44.319 14.428 1.00 20.20 ? 56 TYR B OH 1 ATOM 2374 N N . LEU B 1 37 ? 55.981 -43.369 12.319 1.00 18.20 ? 57 LEU B N 1 ATOM 2375 C CA . LEU B 1 37 ? 55.922 -43.440 10.851 1.00 15.84 ? 57 LEU B CA 1 ATOM 2376 C C . LEU B 1 37 ? 56.879 -42.486 10.153 1.00 15.46 ? 57 LEU B C 1 ATOM 2377 O O . LEU B 1 37 ? 57.502 -42.840 9.114 1.00 16.15 ? 57 LEU B O 1 ATOM 2378 C CB . LEU B 1 37 ? 54.510 -43.219 10.328 1.00 16.99 ? 57 LEU B CB 1 ATOM 2379 C CG . LEU B 1 37 ? 53.452 -44.194 10.845 1.00 18.26 ? 57 LEU B CG 1 ATOM 2380 C CD1 . LEU B 1 37 ? 52.110 -43.817 10.195 1.00 19.08 ? 57 LEU B CD1 1 ATOM 2381 C CD2 . LEU B 1 37 ? 53.746 -45.673 10.600 1.00 17.95 ? 57 LEU B CD2 1 ATOM 2382 N N . ALA B 1 38 ? 56.967 -41.268 10.655 1.00 14.57 ? 58 ALA B N 1 ATOM 2383 C CA . ALA B 1 38 ? 57.797 -40.251 10.025 1.00 16.13 ? 58 ALA B CA 1 ATOM 2384 C C . ALA B 1 38 ? 59.289 -40.662 10.006 1.00 15.82 ? 58 ALA B C 1 ATOM 2385 O O . ALA B 1 38 ? 60.018 -40.321 9.068 1.00 15.13 ? 58 ALA B O 1 ATOM 2386 C CB . ALA B 1 38 ? 57.599 -38.888 10.667 1.00 15.37 ? 58 ALA B CB 1 ATOM 2387 N N . ASN B 1 39 ? 59.678 -41.403 11.031 1.00 16.14 ? 59 ASN B N 1 ATOM 2388 C CA . ASN B 1 39 ? 61.059 -41.851 11.207 1.00 16.04 ? 59 ASN B CA 1 ATOM 2389 C C . ASN B 1 39 ? 61.508 -42.832 10.168 1.00 15.71 ? 59 ASN B C 1 ATOM 2390 O O . ASN B 1 39 ? 62.717 -42.937 9.938 1.00 15.09 ? 59 ASN B O 1 ATOM 2391 C CB . ASN B 1 39 ? 61.272 -42.450 12.596 1.00 15.73 ? 59 ASN B CB 1 ATOM 2392 C CG . ASN B 1 39 ? 61.326 -41.378 13.690 1.00 15.67 ? 59 ASN B CG 1 ATOM 2393 O OD1 . ASN B 1 39 ? 61.439 -40.161 13.408 1.00 14.60 ? 59 ASN B OD1 1 ATOM 2394 N ND2 . ASN B 1 39 ? 61.205 -41.823 14.941 1.00 16.95 ? 59 ASN B ND2 1 ATOM 2395 N N . VAL B 1 40 ? 60.556 -43.526 9.553 1.00 15.13 ? 60 VAL B N 1 ATOM 2396 C CA . VAL B 1 40 ? 60.869 -44.522 8.572 1.00 15.53 ? 60 VAL B CA 1 ATOM 2397 C C . VAL B 1 40 ? 60.435 -44.133 7.153 1.00 15.66 ? 60 VAL B C 1 ATOM 2398 O O . VAL B 1 40 ? 60.582 -44.927 6.245 1.00 15.12 ? 60 VAL B O 1 ATOM 2399 C CB . VAL B 1 40 ? 60.329 -45.909 8.973 1.00 17.78 ? 60 VAL B CB 1 ATOM 2400 C CG1 . VAL B 1 40 ? 60.908 -46.355 10.324 1.00 18.20 ? 60 VAL B CG1 1 ATOM 2401 C CG2 . VAL B 1 40 ? 58.793 -45.965 8.987 1.00 19.14 ? 60 VAL B CG2 1 ATOM 2402 N N . ALA B 1 41 ? 59.889 -42.920 6.980 1.00 15.97 ? 61 ALA B N 1 ATOM 2403 C CA . ALA B 1 41 ? 59.210 -42.514 5.742 1.00 16.57 ? 61 ALA B CA 1 ATOM 2404 C C . ALA B 1 41 ? 60.148 -42.319 4.556 1.00 15.75 ? 61 ALA B C 1 ATOM 2405 O O . ALA B 1 41 ? 59.677 -42.308 3.416 1.00 14.79 ? 61 ALA B O 1 ATOM 2406 C CB . ALA B 1 41 ? 58.394 -41.246 5.951 1.00 18.14 ? 61 ALA B CB 1 ATOM 2407 N N . THR B 1 42 ? 61.418 -42.113 4.831 1.00 15.34 ? 62 THR B N 1 ATOM 2408 C CA . THR B 1 42 ? 62.438 -41.943 3.790 1.00 17.34 ? 62 THR B CA 1 ATOM 2409 C C . THR B 1 42 ? 63.344 -43.153 3.626 1.00 17.42 ? 62 THR B C 1 ATOM 2410 O O . THR B 1 42 ? 64.138 -43.191 2.667 1.00 16.94 ? 62 THR B O 1 ATOM 2411 C CB . THR B 1 42 ? 63.356 -40.745 4.033 1.00 18.30 ? 62 THR B CB 1 ATOM 2412 O OG1 . THR B 1 42 ? 64.093 -40.892 5.229 1.00 18.47 ? 62 THR B OG1 1 ATOM 2413 C CG2 . THR B 1 42 ? 62.537 -39.546 4.241 1.00 21.70 ? 62 THR B CG2 1 ATOM 2414 N N . TRP B 1 43 ? 63.156 -44.148 4.479 1.00 14.85 ? 63 TRP B N 1 ATOM 2415 C CA . TRP B 1 43 ? 63.982 -45.321 4.460 1.00 16.69 ? 63 TRP B CA 1 ATOM 2416 C C . TRP B 1 43 ? 64.148 -45.926 3.054 1.00 16.29 ? 63 TRP B C 1 ATOM 2417 O O . TRP B 1 43 ? 65.248 -46.332 2.662 1.00 16.33 ? 63 TRP B O 1 ATOM 2418 C CB . TRP B 1 43 ? 63.494 -46.373 5.451 1.00 15.20 ? 63 TRP B CB 1 ATOM 2419 C CG . TRP B 1 43 ? 64.304 -47.659 5.323 1.00 17.42 ? 63 TRP B CG 1 ATOM 2420 C CD1 . TRP B 1 43 ? 65.490 -47.945 5.899 1.00 17.70 ? 63 TRP B CD1 1 ATOM 2421 C CD2 . TRP B 1 43 ? 63.918 -48.810 4.562 1.00 18.06 ? 63 TRP B CD2 1 ATOM 2422 N NE1 . TRP B 1 43 ? 65.880 -49.229 5.539 1.00 20.06 ? 63 TRP B NE1 1 ATOM 2423 C CE2 . TRP B 1 43 ? 64.934 -49.766 4.703 1.00 19.12 ? 63 TRP B CE2 1 ATOM 2424 C CE3 . TRP B 1 43 ? 62.809 -49.105 3.732 1.00 20.04 ? 63 TRP B CE3 1 ATOM 2425 C CZ2 . TRP B 1 43 ? 64.871 -51.002 4.102 1.00 19.86 ? 63 TRP B CZ2 1 ATOM 2426 C CZ3 . TRP B 1 43 ? 62.741 -50.346 3.125 1.00 20.95 ? 63 TRP B CZ3 1 ATOM 2427 C CH2 . TRP B 1 43 ? 63.773 -51.293 3.329 1.00 19.78 ? 63 TRP B CH2 1 ATOM 2428 N N . ALA B 1 44 ? 63.058 -46.055 2.332 1.00 17.60 ? 64 ALA B N 1 ATOM 2429 C CA . ALA B 1 44 ? 63.105 -46.724 1.047 1.00 16.39 ? 64 ALA B CA 1 ATOM 2430 C C . ALA B 1 44 ? 64.116 -46.060 0.104 1.00 16.16 ? 64 ALA B C 1 ATOM 2431 O O . ALA B 1 44 ? 64.699 -46.726 -0.743 1.00 16.39 ? 64 ALA B O 1 ATOM 2432 C CB . ALA B 1 44 ? 61.696 -46.871 0.421 1.00 16.19 ? 64 ALA B CB 1 ATOM 2433 N N . ASN B 1 45 ? 64.248 -44.761 0.200 1.00 15.90 ? 65 ASN B N 1 ATOM 2434 C CA . ASN B 1 45 ? 65.175 -44.019 -0.576 1.00 18.03 ? 65 ASN B CA 1 ATOM 2435 C C . ASN B 1 45 ? 66.651 -44.335 -0.200 1.00 20.76 ? 65 ASN B C 1 ATOM 2436 O O . ASN B 1 45 ? 67.448 -44.598 -1.080 1.00 21.74 ? 65 ASN B O 1 ATOM 2437 C CB . ASN B 1 45 ? 64.916 -42.508 -0.546 1.00 16.85 ? 65 ASN B CB 1 ATOM 2438 C CG . ASN B 1 45 ? 63.787 -42.067 -1.479 1.00 17.21 ? 65 ASN B CG 1 ATOM 2439 O OD1 . ASN B 1 45 ? 63.288 -42.828 -2.311 1.00 16.55 ? 65 ASN B OD1 1 ATOM 2440 N ND2 . ASN B 1 45 ? 63.302 -40.877 -1.247 1.00 17.06 ? 65 ASN B ND2 1 ATOM 2441 N N . THR B 1 46 ? 66.945 -44.422 1.095 1.00 20.80 ? 66 THR B N 1 ATOM 2442 C CA . THR B 1 46 ? 68.261 -44.936 1.549 1.00 19.75 ? 66 THR B CA 1 ATOM 2443 C C . THR B 1 46 ? 68.543 -46.324 1.047 1.00 18.08 ? 66 THR B C 1 ATOM 2444 O O . THR B 1 46 ? 69.642 -46.575 0.480 1.00 19.50 ? 66 THR B O 1 ATOM 2445 C CB . THR B 1 46 ? 68.349 -44.948 3.086 1.00 21.24 ? 66 THR B CB 1 ATOM 2446 O OG1 . THR B 1 46 ? 68.090 -43.629 3.518 1.00 20.84 ? 66 THR B OG1 1 ATOM 2447 C CG2 . THR B 1 46 ? 69.727 -45.341 3.590 1.00 21.47 ? 66 THR B CG2 1 ATOM 2448 N N . TYR B 1 47 ? 67.540 -47.179 1.158 1.00 17.38 ? 67 TYR B N 1 ATOM 2449 C CA . TYR B 1 47 ? 67.660 -48.561 0.804 1.00 17.31 ? 67 TYR B CA 1 ATOM 2450 C C . TYR B 1 47 ? 67.953 -48.797 -0.681 1.00 18.53 ? 67 TYR B C 1 ATOM 2451 O O . TYR B 1 47 ? 68.791 -49.674 -1.025 1.00 15.53 ? 67 TYR B O 1 ATOM 2452 C CB . TYR B 1 47 ? 66.451 -49.311 1.243 1.00 17.66 ? 67 TYR B CB 1 ATOM 2453 C CG . TYR B 1 47 ? 66.503 -50.804 1.047 1.00 18.52 ? 67 TYR B CG 1 ATOM 2454 C CD1 . TYR B 1 47 ? 67.401 -51.596 1.744 1.00 20.42 ? 67 TYR B CD1 1 ATOM 2455 C CD2 . TYR B 1 47 ? 65.579 -51.432 0.212 1.00 19.95 ? 67 TYR B CD2 1 ATOM 2456 C CE1 . TYR B 1 47 ? 67.394 -52.995 1.618 1.00 19.32 ? 67 TYR B CE1 1 ATOM 2457 C CE2 . TYR B 1 47 ? 65.539 -52.806 0.089 1.00 21.67 ? 67 TYR B CE2 1 ATOM 2458 C CZ . TYR B 1 47 ? 66.459 -53.580 0.782 1.00 21.46 ? 67 TYR B CZ 1 ATOM 2459 O OH . TYR B 1 47 ? 66.365 -54.917 0.604 1.00 23.04 ? 67 TYR B OH 1 ATOM 2460 N N . LYS B 1 48 ? 67.308 -47.996 -1.553 1.00 15.85 ? 68 LYS B N 1 ATOM 2461 C CA . LYS B 1 48 ? 67.465 -48.205 -2.997 1.00 16.56 ? 68 LYS B CA 1 ATOM 2462 C C . LYS B 1 48 ? 68.913 -47.951 -3.554 1.00 16.70 ? 68 LYS B C 1 ATOM 2463 O O . LYS B 1 48 ? 69.221 -48.362 -4.679 1.00 15.84 ? 68 LYS B O 1 ATOM 2464 C CB . LYS B 1 48 ? 66.425 -47.411 -3.790 1.00 16.55 ? 68 LYS B CB 1 ATOM 2465 C CG . LYS B 1 48 ? 66.705 -45.929 -3.895 1.00 16.04 ? 68 LYS B CG 1 ATOM 2466 C CD . LYS B 1 48 ? 65.483 -45.253 -4.480 1.00 17.12 ? 68 LYS B CD 1 ATOM 2467 C CE . LYS B 1 48 ? 65.605 -43.769 -4.768 1.00 16.27 ? 68 LYS B CE 1 ATOM 2468 N NZ . LYS B 1 48 ? 64.291 -43.188 -5.203 1.00 16.51 ? 68 LYS B NZ 1 ATOM 2469 N N . TYR B 1 49 ? 69.711 -47.190 -2.778 1.00 17.63 ? 69 TYR B N 1 ATOM 2470 C CA . TYR B 1 49 ? 71.109 -46.899 -3.094 1.00 19.86 ? 69 TYR B CA 1 ATOM 2471 C C . TYR B 1 49 ? 72.147 -47.887 -2.486 1.00 18.76 ? 69 TYR B C 1 ATOM 2472 O O . TYR B 1 49 ? 73.325 -47.644 -2.581 1.00 19.70 ? 69 TYR B O 1 ATOM 2473 C CB . TYR B 1 49 ? 71.478 -45.460 -2.757 1.00 20.91 ? 69 TYR B CB 1 ATOM 2474 C CG . TYR B 1 49 ? 70.714 -44.470 -3.583 1.00 23.26 ? 69 TYR B CG 1 ATOM 2475 C CD1 . TYR B 1 49 ? 70.848 -44.453 -4.975 1.00 25.66 ? 69 TYR B CD1 1 ATOM 2476 C CD2 . TYR B 1 49 ? 69.798 -43.602 -3.001 1.00 24.52 ? 69 TYR B CD2 1 ATOM 2477 C CE1 . TYR B 1 49 ? 70.127 -43.582 -5.751 1.00 26.89 ? 69 TYR B CE1 1 ATOM 2478 C CE2 . TYR B 1 49 ? 69.077 -42.695 -3.776 1.00 25.44 ? 69 TYR B CE2 1 ATOM 2479 C CZ . TYR B 1 49 ? 69.229 -42.711 -5.140 1.00 28.22 ? 69 TYR B CZ 1 ATOM 2480 O OH . TYR B 1 49 ? 68.523 -41.873 -5.921 1.00 32.18 ? 69 TYR B OH 1 ATOM 2481 N N . THR B 1 50 ? 71.664 -48.939 -1.865 1.00 18.47 ? 70 THR B N 1 ATOM 2482 C CA . THR B 1 50 ? 72.475 -49.984 -1.235 1.00 20.22 ? 70 THR B CA 1 ATOM 2483 C C . THR B 1 50 ? 72.448 -51.170 -2.168 1.00 20.21 ? 70 THR B C 1 ATOM 2484 O O . THR B 1 50 ? 71.518 -51.325 -2.962 1.00 20.63 ? 70 THR B O 1 ATOM 2485 C CB . THR B 1 50 ? 71.951 -50.464 0.163 1.00 17.55 ? 70 THR B CB 1 ATOM 2486 O OG1 . THR B 1 50 ? 70.757 -51.244 0.023 1.00 18.57 ? 70 THR B OG1 1 ATOM 2487 C CG2 . THR B 1 50 ? 71.707 -49.339 1.090 1.00 18.01 ? 70 THR B CG2 1 ATOM 2488 N N . ASP B 1 51 ? 73.474 -51.998 -2.093 1.00 24.86 ? 71 ASP B N 1 ATOM 2489 C CA . ASP B 1 51 ? 73.552 -53.187 -2.954 1.00 25.70 ? 71 ASP B CA 1 ATOM 2490 C C . ASP B 1 51 ? 72.299 -54.049 -2.828 1.00 24.39 ? 71 ASP B C 1 ATOM 2491 O O . ASP B 1 51 ? 71.745 -54.473 -3.812 1.00 23.82 ? 71 ASP B O 1 ATOM 2492 C CB . ASP B 1 51 ? 74.719 -54.097 -2.577 1.00 27.72 ? 71 ASP B CB 1 ATOM 2493 C CG . ASP B 1 51 ? 76.092 -53.451 -2.747 1.00 30.62 ? 71 ASP B CG 1 ATOM 2494 O OD1 . ASP B 1 51 ? 76.286 -52.574 -3.570 1.00 29.88 ? 71 ASP B OD1 1 ATOM 2495 O OD2 . ASP B 1 51 ? 77.017 -53.839 -1.984 1.00 35.50 ? 71 ASP B OD2 1 ATOM 2496 N N . ALA B 1 52 ? 71.886 -54.347 -1.606 1.00 23.93 ? 72 ALA B N 1 ATOM 2497 C CA . ALA B 1 52 ? 70.727 -55.228 -1.371 1.00 24.89 ? 72 ALA B CA 1 ATOM 2498 C C . ALA B 1 52 ? 69.400 -54.602 -1.872 1.00 24.60 ? 72 ALA B C 1 ATOM 2499 O O . ALA B 1 52 ? 68.506 -55.316 -2.249 1.00 26.93 ? 72 ALA B O 1 ATOM 2500 C CB . ALA B 1 52 ? 70.589 -55.577 0.113 1.00 26.48 ? 72 ALA B CB 1 ATOM 2501 N N . GLY B 1 53 ? 69.302 -53.290 -1.843 1.00 23.19 ? 73 GLY B N 1 ATOM 2502 C CA . GLY B 1 53 ? 68.072 -52.601 -2.190 1.00 22.30 ? 73 GLY B CA 1 ATOM 2503 C C . GLY B 1 53 ? 67.988 -51.968 -3.574 1.00 20.87 ? 73 GLY B C 1 ATOM 2504 O O . GLY B 1 53 ? 66.923 -51.444 -3.934 1.00 18.30 ? 73 GLY B O 1 ATOM 2505 N N . GLU B 1 54 ? 69.054 -52.072 -4.392 1.00 20.21 ? 74 GLU B N 1 ATOM 2506 C CA . GLU B 1 54 ? 69.019 -51.499 -5.768 1.00 20.25 ? 74 GLU B CA 1 ATOM 2507 C C . GLU B 1 54 ? 67.835 -51.984 -6.599 1.00 19.27 ? 74 GLU B C 1 ATOM 2508 O O . GLU B 1 54 ? 67.262 -51.198 -7.345 1.00 18.11 ? 74 GLU B O 1 ATOM 2509 C CB . GLU B 1 54 ? 70.327 -51.690 -6.577 1.00 20.11 ? 74 GLU B CB 1 ATOM 2510 C CG . GLU B 1 54 ? 71.457 -50.749 -6.115 1.00 19.41 ? 74 GLU B CG 1 ATOM 2511 C CD . GLU B 1 54 ? 71.506 -49.388 -6.748 1.00 17.92 ? 74 GLU B CD 1 ATOM 2512 O OE1 . GLU B 1 54 ? 70.853 -49.136 -7.790 1.00 16.57 ? 74 GLU B OE1 1 ATOM 2513 O OE2 . GLU B 1 54 ? 72.236 -48.538 -6.188 1.00 16.71 ? 74 GLU B OE2 1 ATOM 2514 N N . PHE B 1 55 ? 67.458 -53.255 -6.417 1.00 18.20 ? 75 PHE B N 1 ATOM 2515 C CA . PHE B 1 55 ? 66.341 -53.854 -7.128 1.00 20.25 ? 75 PHE B CA 1 ATOM 2516 C C . PHE B 1 55 ? 65.009 -53.094 -6.902 1.00 17.88 ? 75 PHE B C 1 ATOM 2517 O O . PHE B 1 55 ? 64.060 -53.270 -7.671 1.00 18.39 ? 75 PHE B O 1 ATOM 2518 C CB . PHE B 1 55 ? 66.129 -55.356 -6.704 1.00 21.25 ? 75 PHE B CB 1 ATOM 2519 C CG . PHE B 1 55 ? 65.403 -55.516 -5.392 1.00 21.18 ? 75 PHE B CG 1 ATOM 2520 C CD1 . PHE B 1 55 ? 66.076 -55.353 -4.201 1.00 21.00 ? 75 PHE B CD1 1 ATOM 2521 C CD2 . PHE B 1 55 ? 64.047 -55.762 -5.351 1.00 21.24 ? 75 PHE B CD2 1 ATOM 2522 C CE1 . PHE B 1 55 ? 65.432 -55.458 -2.974 1.00 21.81 ? 75 PHE B CE1 1 ATOM 2523 C CE2 . PHE B 1 55 ? 63.399 -55.885 -4.134 1.00 23.19 ? 75 PHE B CE2 1 ATOM 2524 C CZ . PHE B 1 55 ? 64.074 -55.718 -2.933 1.00 20.98 ? 75 PHE B CZ 1 ATOM 2525 N N . SER B 1 56 ? 64.909 -52.387 -5.791 1.00 16.98 ? 76 SER B N 1 ATOM 2526 C CA . SER B 1 56 ? 63.661 -51.738 -5.386 1.00 16.86 ? 76 SER B CA 1 ATOM 2527 C C . SER B 1 56 ? 63.480 -50.335 -5.951 1.00 17.02 ? 76 SER B C 1 ATOM 2528 O O . SER B 1 56 ? 62.415 -49.759 -5.719 1.00 14.52 ? 76 SER B O 1 ATOM 2529 C CB . SER B 1 56 ? 63.499 -51.693 -3.847 1.00 15.22 ? 76 SER B CB 1 ATOM 2530 O OG . SER B 1 56 ? 64.467 -50.860 -3.218 1.00 14.41 ? 76 SER B OG 1 ATOM 2531 N N . LYS B 1 57 ? 64.463 -49.806 -6.707 1.00 16.31 ? 77 LYS B N 1 ATOM 2532 C CA . LYS B 1 57 ? 64.339 -48.482 -7.335 1.00 17.08 ? 77 LYS B CA 1 ATOM 2533 C C . LYS B 1 57 ? 63.063 -48.256 -8.163 1.00 16.21 ? 77 LYS B C 1 ATOM 2534 O O . LYS B 1 57 ? 62.493 -47.206 -8.067 1.00 17.59 ? 77 LYS B O 1 ATOM 2535 C CB . LYS B 1 57 ? 65.515 -48.128 -8.249 1.00 16.57 ? 77 LYS B CB 1 ATOM 2536 C CG . LYS B 1 57 ? 66.703 -47.566 -7.536 1.00 17.36 ? 77 LYS B CG 1 ATOM 2537 C CD . LYS B 1 57 ? 67.784 -47.207 -8.549 1.00 18.13 ? 77 LYS B CD 1 ATOM 2538 C CE . LYS B 1 57 ? 68.971 -46.639 -7.794 1.00 18.46 ? 77 LYS B CE 1 ATOM 2539 N NZ . LYS B 1 57 ? 70.038 -46.172 -8.709 1.00 20.93 ? 77 LYS B NZ 1 ATOM 2540 N N . PRO B 1 58 ? 62.684 -49.214 -9.004 1.00 17.83 ? 78 PRO B N 1 ATOM 2541 C CA . PRO B 1 58 ? 61.441 -49.098 -9.798 1.00 17.84 ? 78 PRO B CA 1 ATOM 2542 C C . PRO B 1 58 ? 60.138 -49.111 -8.980 1.00 16.14 ? 78 PRO B C 1 ATOM 2543 O O . PRO B 1 58 ? 59.105 -48.751 -9.509 1.00 16.61 ? 78 PRO B O 1 ATOM 2544 C CB . PRO B 1 58 ? 61.458 -50.374 -10.693 1.00 18.47 ? 78 PRO B CB 1 ATOM 2545 C CG . PRO B 1 58 ? 62.855 -50.909 -10.593 1.00 19.31 ? 78 PRO B CG 1 ATOM 2546 C CD . PRO B 1 58 ? 63.334 -50.526 -9.238 1.00 19.07 ? 78 PRO B CD 1 ATOM 2547 N N . TYR B 1 59 ? 60.211 -49.520 -7.713 1.00 15.42 ? 79 TYR B N 1 ATOM 2548 C CA . TYR B 1 59 ? 59.043 -49.581 -6.838 1.00 15.98 ? 79 TYR B CA 1 ATOM 2549 C C . TYR B 1 59 ? 58.544 -48.203 -6.404 1.00 14.97 ? 79 TYR B C 1 ATOM 2550 O O . TYR B 1 59 ? 57.501 -48.123 -5.791 1.00 15.20 ? 79 TYR B O 1 ATOM 2551 C CB . TYR B 1 59 ? 59.287 -50.421 -5.607 1.00 16.08 ? 79 TYR B CB 1 ATOM 2552 C CG . TYR B 1 59 ? 59.680 -51.892 -5.824 1.00 18.31 ? 79 TYR B CG 1 ATOM 2553 C CD1 . TYR B 1 59 ? 59.661 -52.517 -7.087 1.00 20.06 ? 79 TYR B CD1 1 ATOM 2554 C CD2 . TYR B 1 59 ? 60.053 -52.671 -4.729 1.00 18.35 ? 79 TYR B CD2 1 ATOM 2555 C CE1 . TYR B 1 59 ? 60.013 -53.869 -7.246 1.00 20.54 ? 79 TYR B CE1 1 ATOM 2556 C CE2 . TYR B 1 59 ? 60.386 -54.003 -4.875 1.00 18.07 ? 79 TYR B CE2 1 ATOM 2557 C CZ . TYR B 1 59 ? 60.369 -54.597 -6.123 1.00 18.63 ? 79 TYR B CZ 1 ATOM 2558 O OH . TYR B 1 59 ? 60.690 -55.916 -6.232 1.00 19.49 ? 79 TYR B OH 1 ATOM 2559 N N . HIS B 1 60 ? 59.238 -47.144 -6.786 1.00 15.06 ? 80 HIS B N 1 ATOM 2560 C CA . HIS B 1 60 ? 58.879 -45.781 -6.375 1.00 15.36 ? 80 HIS B CA 1 ATOM 2561 C C . HIS B 1 60 ? 57.891 -45.063 -7.317 1.00 15.68 ? 80 HIS B C 1 ATOM 2562 O O . HIS B 1 60 ? 57.389 -43.961 -6.971 1.00 12.44 ? 80 HIS B O 1 ATOM 2563 C CB . HIS B 1 60 ? 60.159 -44.974 -6.136 1.00 15.04 ? 80 HIS B CB 1 ATOM 2564 C CG . HIS B 1 60 ? 60.958 -45.479 -4.983 1.00 16.35 ? 80 HIS B CG 1 ATOM 2565 N ND1 . HIS B 1 60 ? 61.282 -44.702 -3.887 1.00 16.97 ? 80 HIS B ND1 1 ATOM 2566 C CD2 . HIS B 1 60 ? 61.526 -46.696 -4.754 1.00 17.78 ? 80 HIS B CD2 1 ATOM 2567 C CE1 . HIS B 1 60 ? 61.962 -45.424 -3.016 1.00 17.13 ? 80 HIS B CE1 1 ATOM 2568 N NE2 . HIS B 1 60 ? 62.148 -46.629 -3.531 1.00 17.68 ? 80 HIS B NE2 1 ATOM 2569 N N . PHE B 1 61 ? 57.631 -45.661 -8.496 1.00 13.74 ? 81 PHE B N 1 ATOM 2570 C CA . PHE B 1 61 ? 56.895 -44.977 -9.550 1.00 13.20 ? 81 PHE B CA 1 ATOM 2571 C C . PHE B 1 61 ? 56.188 -45.975 -10.484 1.00 13.36 ? 81 PHE B C 1 ATOM 2572 O O . PHE B 1 61 ? 56.386 -47.205 -10.394 1.00 13.98 ? 81 PHE B O 1 ATOM 2573 C CB . PHE B 1 61 ? 57.791 -43.964 -10.313 1.00 13.96 ? 81 PHE B CB 1 ATOM 2574 C CG . PHE B 1 61 ? 59.034 -44.587 -10.928 1.00 14.04 ? 81 PHE B CG 1 ATOM 2575 C CD1 . PHE B 1 61 ? 58.969 -45.302 -12.132 1.00 13.97 ? 81 PHE B CD1 1 ATOM 2576 C CD2 . PHE B 1 61 ? 60.236 -44.553 -10.228 1.00 15.01 ? 81 PHE B CD2 1 ATOM 2577 C CE1 . PHE B 1 61 ? 60.109 -45.905 -12.655 1.00 14.59 ? 81 PHE B CE1 1 ATOM 2578 C CE2 . PHE B 1 61 ? 61.377 -45.168 -10.740 1.00 15.26 ? 81 PHE B CE2 1 ATOM 2579 C CZ . PHE B 1 61 ? 61.317 -45.850 -11.955 1.00 14.52 ? 81 PHE B CZ 1 ATOM 2580 N N . ILE B 1 62 ? 55.277 -45.465 -11.271 1.00 12.90 ? 82 ILE B N 1 ATOM 2581 C CA . ILE B 1 62 ? 54.745 -46.228 -12.396 1.00 13.50 ? 82 ILE B CA 1 ATOM 2582 C C . ILE B 1 62 ? 54.857 -45.311 -13.613 1.00 13.79 ? 82 ILE B C 1 ATOM 2583 O O . ILE B 1 62 ? 54.296 -44.228 -13.654 1.00 13.53 ? 82 ILE B O 1 ATOM 2584 C CB . ILE B 1 62 ? 53.327 -46.821 -12.142 1.00 13.31 ? 82 ILE B CB 1 ATOM 2585 C CG1 . ILE B 1 62 ? 52.860 -47.624 -13.352 1.00 13.69 ? 82 ILE B CG1 1 ATOM 2586 C CG2 . ILE B 1 62 ? 52.352 -45.716 -11.762 1.00 14.38 ? 82 ILE B CG2 1 ATOM 2587 C CD1 . ILE B 1 62 ? 51.634 -48.504 -13.138 1.00 14.14 ? 82 ILE B CD1 1 ATOM 2588 N N . ASP B 1 63 ? 55.596 -45.762 -14.617 1.00 15.36 ? 83 ASP B N 1 ATOM 2589 C CA . ASP B 1 63 ? 55.856 -44.951 -15.806 1.00 16.12 ? 83 ASP B CA 1 ATOM 2590 C C . ASP B 1 63 ? 54.673 -44.989 -16.839 1.00 16.39 ? 83 ASP B C 1 ATOM 2591 O O . ASP B 1 63 ? 54.768 -45.615 -17.916 1.00 16.45 ? 83 ASP B O 1 ATOM 2592 C CB . ASP B 1 63 ? 57.151 -45.389 -16.487 1.00 16.83 ? 83 ASP B CB 1 ATOM 2593 C CG . ASP B 1 63 ? 58.419 -44.753 -15.839 1.00 19.00 ? 83 ASP B CG 1 ATOM 2594 O OD1 . ASP B 1 63 ? 58.332 -43.680 -15.199 1.00 16.50 ? 83 ASP B OD1 1 ATOM 2595 O OD2 . ASP B 1 63 ? 59.506 -45.379 -15.992 1.00 20.69 ? 83 ASP B OD2 1 ATOM 2596 N N . ALA B 1 64 ? 53.652 -44.212 -16.539 1.00 15.66 ? 84 ALA B N 1 ATOM 2597 C CA . ALA B 1 64 ? 52.476 -44.152 -17.380 1.00 16.33 ? 84 ALA B CA 1 ATOM 2598 C C . ALA B 1 64 ? 52.802 -43.603 -18.802 1.00 17.30 ? 84 ALA B C 1 ATOM 2599 O O . ALA B 1 64 ? 53.297 -42.472 -18.955 1.00 14.96 ? 84 ALA B O 1 ATOM 2600 C CB . ALA B 1 64 ? 51.436 -43.276 -16.760 1.00 14.76 ? 84 ALA B CB 1 ATOM 2601 N N . GLN B 1 65 ? 52.521 -44.422 -19.813 1.00 18.96 ? 85 GLN B N 1 ATOM 2602 C CA . GLN B 1 65 ? 52.840 -44.083 -21.212 1.00 20.82 ? 85 GLN B CA 1 ATOM 2603 C C . GLN B 1 65 ? 51.711 -43.350 -21.899 1.00 19.82 ? 85 GLN B C 1 ATOM 2604 O O . GLN B 1 65 ? 51.152 -43.844 -22.855 1.00 20.60 ? 85 GLN B O 1 ATOM 2605 C CB . GLN B 1 65 ? 53.260 -45.355 -21.971 1.00 21.23 ? 85 GLN B CB 1 ATOM 2606 C CG . GLN B 1 65 ? 54.505 -45.990 -21.382 1.00 22.68 ? 85 GLN B CG 1 ATOM 2607 C CD . GLN B 1 65 ? 54.903 -47.265 -22.117 1.00 25.98 ? 85 GLN B CD 1 ATOM 2608 O OE1 . GLN B 1 65 ? 55.114 -47.240 -23.294 1.00 35.87 ? 85 GLN B OE1 1 ATOM 2609 N NE2 . GLN B 1 65 ? 54.974 -48.351 -21.435 1.00 24.96 ? 85 GLN B NE2 1 ATOM 2610 N N . ASP B 1 66 ? 51.424 -42.161 -21.404 1.00 16.74 ? 86 ASP B N 1 ATOM 2611 C CA . ASP B 1 66 ? 50.312 -41.347 -21.852 1.00 16.67 ? 86 ASP B CA 1 ATOM 2612 C C . ASP B 1 66 ? 50.881 -40.122 -22.658 1.00 15.79 ? 86 ASP B C 1 ATOM 2613 O O . ASP B 1 66 ? 52.012 -40.208 -23.098 1.00 16.37 ? 86 ASP B O 1 ATOM 2614 C CB . ASP B 1 66 ? 49.389 -40.991 -20.676 1.00 15.75 ? 86 ASP B CB 1 ATOM 2615 C CG . ASP B 1 66 ? 50.101 -40.207 -19.559 1.00 17.22 ? 86 ASP B CG 1 ATOM 2616 O OD1 . ASP B 1 66 ? 51.347 -39.939 -19.655 1.00 15.94 ? 86 ASP B OD1 1 ATOM 2617 O OD2 . ASP B 1 66 ? 49.387 -39.916 -18.551 1.00 15.89 ? 86 ASP B OD2 1 ATOM 2618 N N . ASN B 1 67 ? 50.116 -39.070 -22.860 1.00 14.23 ? 87 ASN B N 1 ATOM 2619 C CA . ASN B 1 67 ? 50.502 -37.953 -23.729 1.00 16.76 ? 87 ASN B CA 1 ATOM 2620 C C . ASN B 1 67 ? 50.172 -36.583 -23.157 1.00 16.45 ? 87 ASN B C 1 ATOM 2621 O O . ASN B 1 67 ? 49.357 -35.855 -23.694 1.00 16.25 ? 87 ASN B O 1 ATOM 2622 C CB . ASN B 1 67 ? 49.867 -38.126 -25.154 1.00 18.77 ? 87 ASN B CB 1 ATOM 2623 C CG . ASN B 1 67 ? 50.349 -39.384 -25.817 1.00 20.42 ? 87 ASN B CG 1 ATOM 2624 O OD1 . ASN B 1 67 ? 51.519 -39.472 -26.231 1.00 24.40 ? 87 ASN B OD1 1 ATOM 2625 N ND2 . ASN B 1 67 ? 49.539 -40.408 -25.785 1.00 24.01 ? 87 ASN B ND2 1 ATOM 2626 N N . PRO B 1 68 ? 50.786 -36.249 -22.017 1.00 15.52 ? 88 PRO B N 1 ATOM 2627 C CA . PRO B 1 68 ? 50.425 -35.052 -21.288 1.00 16.25 ? 88 PRO B CA 1 ATOM 2628 C C . PRO B 1 68 ? 51.049 -33.836 -21.970 1.00 16.06 ? 88 PRO B C 1 ATOM 2629 O O . PRO B 1 68 ? 52.061 -33.953 -22.639 1.00 15.98 ? 88 PRO B O 1 ATOM 2630 C CB . PRO B 1 68 ? 51.082 -35.268 -19.922 1.00 16.06 ? 88 PRO B CB 1 ATOM 2631 C CG . PRO B 1 68 ? 52.290 -36.100 -20.279 1.00 16.25 ? 88 PRO B CG 1 ATOM 2632 C CD . PRO B 1 68 ? 51.853 -37.010 -21.368 1.00 15.74 ? 88 PRO B CD 1 ATOM 2633 N N . PRO B 1 69 ? 50.438 -32.692 -21.825 1.00 17.75 ? 89 PRO B N 1 ATOM 2634 C CA . PRO B 1 69 ? 49.240 -32.454 -21.012 1.00 19.00 ? 89 PRO B CA 1 ATOM 2635 C C . PRO B 1 69 ? 47.902 -32.677 -21.706 1.00 20.86 ? 89 PRO B C 1 ATOM 2636 O O . PRO B 1 69 ? 46.866 -32.426 -21.082 1.00 18.34 ? 89 PRO B O 1 ATOM 2637 C CB . PRO B 1 69 ? 49.377 -30.966 -20.691 1.00 21.03 ? 89 PRO B CB 1 ATOM 2638 C CG . PRO B 1 69 ? 50.024 -30.384 -21.931 1.00 19.35 ? 89 PRO B CG 1 ATOM 2639 C CD . PRO B 1 69 ? 51.030 -31.446 -22.342 1.00 19.61 ? 89 PRO B CD 1 ATOM 2640 N N . GLN B 1 70 ? 47.931 -33.123 -22.973 1.00 19.98 ? 90 GLN B N 1 ATOM 2641 C CA . GLN B 1 70 ? 46.711 -33.263 -23.770 1.00 22.16 ? 90 GLN B CA 1 ATOM 2642 C C . GLN B 1 70 ? 45.868 -34.425 -23.308 1.00 21.66 ? 90 GLN B C 1 ATOM 2643 O O . GLN B 1 70 ? 44.652 -34.343 -23.296 1.00 22.14 ? 90 GLN B O 1 ATOM 2644 C CB . GLN B 1 70 ? 47.048 -33.418 -25.290 1.00 22.07 ? 90 GLN B CB 1 ATOM 2645 C CG . GLN B 1 70 ? 47.567 -32.124 -25.940 1.00 22.40 ? 90 GLN B CG 1 ATOM 2646 C CD . GLN B 1 70 ? 48.970 -31.602 -25.443 1.00 25.52 ? 90 GLN B CD 1 ATOM 2647 O OE1 . GLN B 1 70 ? 49.937 -32.372 -25.234 1.00 24.18 ? 90 GLN B OE1 1 ATOM 2648 N NE2 . GLN B 1 70 ? 49.069 -30.302 -25.274 1.00 23.90 ? 90 GLN B NE2 1 ATOM 2649 N N . SER B 1 71 ? 46.529 -35.520 -22.945 1.00 21.90 ? 91 SER B N 1 ATOM 2650 C CA . SER B 1 71 ? 45.849 -36.690 -22.504 1.00 21.25 ? 91 SER B CA 1 ATOM 2651 C C . SER B 1 71 ? 46.652 -37.499 -21.453 1.00 21.91 ? 91 SER B C 1 ATOM 2652 O O . SER B 1 71 ? 47.850 -37.756 -21.641 1.00 19.82 ? 91 SER B O 1 ATOM 2653 C CB . SER B 1 71 ? 45.581 -37.513 -23.739 1.00 24.54 ? 91 SER B CB 1 ATOM 2654 O OG . SER B 1 71 ? 45.212 -38.802 -23.392 1.00 27.43 ? 91 SER B OG 1 ATOM 2655 N N . CYS B 1 72 ? 45.992 -37.861 -20.340 1.00 18.81 ? 92 CYS B N 1 ATOM 2656 C CA . CYS B 1 72 ? 46.598 -38.653 -19.268 1.00 17.14 ? 92 CYS B CA 1 ATOM 2657 C C . CYS B 1 72 ? 45.909 -39.984 -19.086 1.00 17.26 ? 92 CYS B C 1 ATOM 2658 O O . CYS B 1 72 ? 44.723 -40.106 -19.338 1.00 18.21 ? 92 CYS B O 1 ATOM 2659 C CB . CYS B 1 72 ? 46.559 -37.823 -17.994 1.00 19.79 ? 92 CYS B CB 1 ATOM 2660 S SG . CYS B 1 72 ? 47.886 -36.561 -17.947 1.00 19.16 ? 92 CYS B SG 1 ATOM 2661 N N . GLY B 1 73 ? 46.637 -40.975 -18.611 1.00 16.10 ? 93 GLY B N 1 ATOM 2662 C CA . GLY B 1 73 ? 46.100 -42.222 -18.211 1.00 16.06 ? 93 GLY B CA 1 ATOM 2663 C C . GLY B 1 73 ? 47.141 -43.197 -17.771 1.00 15.27 ? 93 GLY B C 1 ATOM 2664 O O . GLY B 1 73 ? 48.253 -43.168 -18.267 1.00 18.99 ? 93 GLY B O 1 ATOM 2665 N N . VAL B 1 74 ? 46.749 -44.104 -16.883 1.00 14.89 ? 94 VAL B N 1 ATOM 2666 C CA . VAL B 1 74 ? 47.611 -45.131 -16.379 1.00 15.63 ? 94 VAL B CA 1 ATOM 2667 C C . VAL B 1 74 ? 46.947 -46.473 -16.712 1.00 15.15 ? 94 VAL B C 1 ATOM 2668 O O . VAL B 1 74 ? 45.847 -46.732 -16.291 1.00 14.47 ? 94 VAL B O 1 ATOM 2669 C CB . VAL B 1 74 ? 47.812 -45.015 -14.848 1.00 16.61 ? 94 VAL B CB 1 ATOM 2670 C CG1 . VAL B 1 74 ? 48.882 -45.998 -14.334 1.00 16.00 ? 94 VAL B CG1 1 ATOM 2671 C CG2 . VAL B 1 74 ? 48.195 -43.575 -14.449 1.00 16.49 ? 94 VAL B CG2 1 ATOM 2672 N N . ASP B 1 75 ? 47.731 -47.366 -17.305 1.00 15.67 ? 95 ASP B N 1 ATOM 2673 C CA . ASP B 1 75 ? 47.302 -48.714 -17.730 1.00 16.63 ? 95 ASP B CA 1 ATOM 2674 C C . ASP B 1 75 ? 48.291 -49.649 -17.081 1.00 15.84 ? 95 ASP B C 1 ATOM 2675 O O . ASP B 1 75 ? 49.455 -49.743 -17.537 1.00 14.78 ? 95 ASP B O 1 ATOM 2676 C CB . ASP B 1 75 ? 47.323 -48.719 -19.291 1.00 16.77 ? 95 ASP B CB 1 ATOM 2677 C CG . ASP B 1 75 ? 47.079 -50.089 -19.981 1.00 17.67 ? 95 ASP B CG 1 ATOM 2678 O OD1 . ASP B 1 75 ? 47.187 -51.166 -19.351 1.00 17.75 ? 95 ASP B OD1 1 ATOM 2679 O OD2 . ASP B 1 75 ? 46.841 -49.963 -21.236 1.00 19.81 ? 95 ASP B OD2 1 ATOM 2680 N N . TYR B 1 76 ? 47.870 -50.311 -15.988 1.00 16.45 ? 96 TYR B N 1 ATOM 2681 C CA . TYR B 1 76 ? 48.783 -51.124 -15.145 1.00 18.34 ? 96 TYR B CA 1 ATOM 2682 C C . TYR B 1 76 ? 49.598 -52.139 -15.972 1.00 18.62 ? 96 TYR B C 1 ATOM 2683 O O . TYR B 1 76 ? 50.810 -52.222 -15.821 1.00 16.80 ? 96 TYR B O 1 ATOM 2684 C CB . TYR B 1 76 ? 48.009 -51.806 -13.985 1.00 18.51 ? 96 TYR B CB 1 ATOM 2685 C CG . TYR B 1 76 ? 48.807 -52.723 -13.100 1.00 19.86 ? 96 TYR B CG 1 ATOM 2686 C CD1 . TYR B 1 76 ? 49.909 -52.251 -12.329 1.00 18.33 ? 96 TYR B CD1 1 ATOM 2687 C CD2 . TYR B 1 76 ? 48.470 -54.076 -12.981 1.00 18.62 ? 96 TYR B CD2 1 ATOM 2688 C CE1 . TYR B 1 76 ? 50.620 -53.116 -11.508 1.00 19.16 ? 96 TYR B CE1 1 ATOM 2689 C CE2 . TYR B 1 76 ? 49.179 -54.916 -12.143 1.00 20.59 ? 96 TYR B CE2 1 ATOM 2690 C CZ . TYR B 1 76 ? 50.257 -54.416 -11.405 1.00 19.68 ? 96 TYR B CZ 1 ATOM 2691 O OH . TYR B 1 76 ? 50.954 -55.250 -10.576 1.00 20.39 ? 96 TYR B OH 1 ATOM 2692 N N . ASP B 1 77 ? 48.934 -52.928 -16.805 1.00 19.50 ? 97 ASP B N 1 ATOM 2693 C CA A ASP B 1 77 ? 49.609 -53.967 -17.608 0.50 20.79 ? 97 ASP B CA 1 ATOM 2694 C CA B ASP B 1 77 ? 49.624 -53.985 -17.525 0.50 20.97 ? 97 ASP B CA 1 ATOM 2695 C C . ASP B 1 77 ? 50.616 -53.387 -18.573 1.00 19.97 ? 97 ASP B C 1 ATOM 2696 O O . ASP B 1 77 ? 51.684 -53.939 -18.777 1.00 19.32 ? 97 ASP B O 1 ATOM 2697 C CB A ASP B 1 77 ? 48.599 -54.783 -18.440 0.50 23.30 ? 97 ASP B CB 1 ATOM 2698 C CB B ASP B 1 77 ? 48.604 -54.988 -18.120 0.50 24.24 ? 97 ASP B CB 1 ATOM 2699 C CG A ASP B 1 77 ? 49.268 -55.929 -19.252 0.50 25.21 ? 97 ASP B CG 1 ATOM 2700 C CG B ASP B 1 77 ? 47.818 -55.783 -17.032 0.50 26.53 ? 97 ASP B CG 1 ATOM 2701 O OD1 A ASP B 1 77 ? 49.528 -56.991 -18.638 0.50 27.71 ? 97 ASP B OD1 1 ATOM 2702 O OD1 B ASP B 1 77 ? 48.405 -56.208 -16.014 0.50 26.88 ? 97 ASP B OD1 1 ATOM 2703 O OD2 A ASP B 1 77 ? 49.503 -55.773 -20.491 0.50 26.34 ? 97 ASP B OD2 1 ATOM 2704 O OD2 B ASP B 1 77 ? 46.593 -56.007 -17.207 0.50 32.27 ? 97 ASP B OD2 1 ATOM 2705 N N . ARG B 1 78 ? 50.263 -52.271 -19.206 1.00 17.63 ? 98 ARG B N 1 ATOM 2706 C CA . ARG B 1 78 ? 51.164 -51.609 -20.122 1.00 16.74 ? 98 ARG B CA 1 ATOM 2707 C C . ARG B 1 78 ? 52.330 -50.939 -19.390 1.00 17.36 ? 98 ARG B C 1 ATOM 2708 O O . ARG B 1 78 ? 53.444 -50.906 -19.902 1.00 16.00 ? 98 ARG B O 1 ATOM 2709 C CB . ARG B 1 78 ? 50.415 -50.535 -20.871 1.00 17.61 ? 98 ARG B CB 1 ATOM 2710 C CG . ARG B 1 78 ? 51.202 -49.822 -21.940 1.00 18.42 ? 98 ARG B CG 1 ATOM 2711 C CD . ARG B 1 78 ? 50.428 -48.655 -22.505 1.00 18.28 ? 98 ARG B CD 1 ATOM 2712 N NE . ARG B 1 78 ? 50.201 -47.643 -21.506 1.00 18.31 ? 98 ARG B NE 1 ATOM 2713 C CZ . ARG B 1 78 ? 49.354 -46.610 -21.606 1.00 17.85 ? 98 ARG B CZ 1 ATOM 2714 N NH1 . ARG B 1 78 ? 48.649 -46.426 -22.683 1.00 18.15 ? 98 ARG B NH1 1 ATOM 2715 N NH2 . ARG B 1 78 ? 49.227 -45.737 -20.593 1.00 17.69 ? 98 ARG B NH2 1 ATOM 2716 N N . ASP B 1 79 ? 52.058 -50.373 -18.210 1.00 15.62 ? 99 ASP B N 1 ATOM 2717 C CA . ASP B 1 79 ? 52.959 -49.373 -17.613 1.00 14.69 ? 99 ASP B CA 1 ATOM 2718 C C . ASP B 1 79 ? 53.848 -49.819 -16.473 1.00 15.61 ? 99 ASP B C 1 ATOM 2719 O O . ASP B 1 79 ? 54.895 -49.189 -16.226 1.00 15.01 ? 99 ASP B O 1 ATOM 2720 C CB . ASP B 1 79 ? 52.159 -48.168 -17.159 1.00 14.28 ? 99 ASP B CB 1 ATOM 2721 C CG . ASP B 1 79 ? 51.520 -47.433 -18.314 1.00 14.73 ? 99 ASP B CG 1 ATOM 2722 O OD1 . ASP B 1 79 ? 52.089 -47.469 -19.428 1.00 14.83 ? 99 ASP B OD1 1 ATOM 2723 O OD2 . ASP B 1 79 ? 50.442 -46.777 -18.122 1.00 13.84 ? 99 ASP B OD2 1 ATOM 2724 N N . CYS B 1 80 ? 53.464 -50.885 -15.768 1.00 17.07 ? 100 CYS B N 1 ATOM 2725 C CA A CYS B 1 80 ? 54.219 -51.339 -14.585 0.50 16.96 ? 100 CYS B CA 1 ATOM 2726 C CA B CYS B 1 80 ? 54.207 -51.352 -14.603 0.50 18.04 ? 100 CYS B CA 1 ATOM 2727 C C . CYS B 1 80 ? 55.628 -51.808 -14.984 1.00 18.02 ? 100 CYS B C 1 ATOM 2728 O O . CYS B 1 80 ? 56.626 -51.267 -14.496 1.00 16.69 ? 100 CYS B O 1 ATOM 2729 C CB A CYS B 1 80 ? 53.483 -52.434 -13.815 0.50 16.55 ? 100 CYS B CB 1 ATOM 2730 C CB B CYS B 1 80 ? 53.479 -52.504 -13.930 0.50 18.77 ? 100 CYS B CB 1 ATOM 2731 S SG A CYS B 1 80 ? 54.158 -52.746 -12.153 0.50 15.37 ? 100 CYS B SG 1 ATOM 2732 S SG B CYS B 1 80 ? 54.504 -53.241 -12.649 0.50 20.55 ? 100 CYS B SG 1 ATOM 2733 N N . GLY B 1 81 ? 55.680 -52.781 -15.885 1.00 18.43 ? 101 GLY B N 1 ATOM 2734 C CA . GLY B 1 81 ? 56.931 -53.294 -16.454 1.00 19.07 ? 101 GLY B CA 1 ATOM 2735 C C . GLY B 1 81 ? 57.416 -54.507 -15.710 1.00 20.24 ? 101 GLY B C 1 ATOM 2736 O O . GLY B 1 81 ? 56.965 -54.814 -14.611 1.00 21.77 ? 101 GLY B O 1 ATOM 2737 N N . SER B 1 82 ? 58.375 -55.205 -16.284 1.00 23.03 ? 102 SER B N 1 ATOM 2738 C CA . SER B 1 82 ? 58.812 -56.492 -15.684 1.00 24.43 ? 102 SER B CA 1 ATOM 2739 C C . SER B 1 82 ? 59.679 -56.332 -14.416 1.00 23.25 ? 102 SER B C 1 ATOM 2740 O O . SER B 1 82 ? 59.783 -57.248 -13.630 1.00 24.79 ? 102 SER B O 1 ATOM 2741 C CB . SER B 1 82 ? 59.580 -57.309 -16.724 1.00 27.02 ? 102 SER B CB 1 ATOM 2742 O OG . SER B 1 82 ? 60.687 -56.528 -17.086 1.00 27.97 ? 102 SER B OG 1 ATOM 2743 N N . ALA B 1 83 ? 60.260 -55.166 -14.183 1.00 21.33 ? 103 ALA B N 1 ATOM 2744 C CA . ALA B 1 83 ? 61.012 -54.920 -12.923 1.00 20.82 ? 103 ALA B CA 1 ATOM 2745 C C . ALA B 1 83 ? 60.119 -54.497 -11.712 1.00 19.87 ? 103 ALA B C 1 ATOM 2746 O O . ALA B 1 83 ? 60.616 -54.284 -10.620 1.00 19.87 ? 103 ALA B O 1 ATOM 2747 C CB . ALA B 1 83 ? 62.068 -53.840 -13.169 1.00 22.86 ? 103 ALA B CB 1 ATOM 2748 N N . GLY B 1 84 ? 58.810 -54.415 -11.919 1.00 19.80 ? 104 GLY B N 1 ATOM 2749 C CA . GLY B 1 84 ? 57.876 -53.955 -10.895 1.00 18.56 ? 104 GLY B CA 1 ATOM 2750 C C . GLY B 1 84 ? 57.740 -52.434 -10.888 1.00 16.18 ? 104 GLY B C 1 ATOM 2751 O O . GLY B 1 84 ? 58.386 -51.692 -11.611 1.00 14.63 ? 104 GLY B O 1 ATOM 2752 N N . CYS B 1 85 ? 56.806 -51.987 -10.064 1.00 16.37 ? 105 CYS B N 1 ATOM 2753 C CA . CYS B 1 85 ? 56.453 -50.570 -9.988 1.00 14.59 ? 105 CYS B CA 1 ATOM 2754 C C . CYS B 1 85 ? 55.801 -50.286 -8.637 1.00 13.48 ? 105 CYS B C 1 ATOM 2755 O O . CYS B 1 85 ? 55.584 -51.206 -7.828 1.00 12.72 ? 105 CYS B O 1 ATOM 2756 C CB . CYS B 1 85 ? 55.528 -50.229 -11.182 1.00 15.16 ? 105 CYS B CB 1 ATOM 2757 S SG . CYS B 1 85 ? 53.907 -51.009 -11.089 1.00 17.27 ? 105 CYS B SG 1 ATOM 2758 N N . SER B 1 86 ? 55.457 -49.014 -8.401 1.00 14.46 ? 106 SER B N 1 ATOM 2759 C CA . SER B 1 86 ? 54.784 -48.618 -7.149 1.00 15.24 ? 106 SER B CA 1 ATOM 2760 C C . SER B 1 86 ? 53.562 -49.520 -6.835 1.00 15.87 ? 106 SER B C 1 ATOM 2761 O O . SER B 1 86 ? 53.362 -49.951 -5.708 1.00 15.77 ? 106 SER B O 1 ATOM 2762 C CB . SER B 1 86 ? 54.369 -47.179 -7.230 1.00 15.35 ? 106 SER B CB 1 ATOM 2763 O OG . SER B 1 86 ? 53.638 -46.905 -8.423 1.00 13.72 ? 106 SER B OG 1 ATOM 2764 N N . ILE B 1 87 ? 52.779 -49.809 -7.873 1.00 16.52 ? 107 ILE B N 1 ATOM 2765 C CA . ILE B 1 87 ? 51.528 -50.530 -7.704 1.00 15.22 ? 107 ILE B CA 1 ATOM 2766 C C . ILE B 1 87 ? 51.819 -52.008 -7.331 1.00 16.06 ? 107 ILE B C 1 ATOM 2767 O O . ILE B 1 87 ? 51.173 -52.530 -6.454 1.00 15.64 ? 107 ILE B O 1 ATOM 2768 C CB . ILE B 1 87 ? 50.666 -50.456 -8.997 1.00 15.67 ? 107 ILE B CB 1 ATOM 2769 C CG1 . ILE B 1 87 ? 50.383 -49.019 -9.392 1.00 16.18 ? 107 ILE B CG1 1 ATOM 2770 C CG2 . ILE B 1 87 ? 49.359 -51.234 -8.857 1.00 15.52 ? 107 ILE B CG2 1 ATOM 2771 C CD1 . ILE B 1 87 ? 49.738 -48.133 -8.323 1.00 17.06 ? 107 ILE B CD1 1 ATOM 2772 N N . SER B 1 88 ? 52.739 -52.658 -8.051 1.00 15.16 ? 108 SER B N 1 ATOM 2773 C CA . SER B 1 88 ? 53.051 -54.048 -7.781 1.00 16.74 ? 108 SER B CA 1 ATOM 2774 C C . SER B 1 88 ? 53.707 -54.211 -6.406 1.00 16.81 ? 108 SER B C 1 ATOM 2775 O O . SER B 1 88 ? 53.532 -55.199 -5.727 1.00 18.63 ? 108 SER B O 1 ATOM 2776 C CB . SER B 1 88 ? 53.923 -54.645 -8.923 1.00 17.56 ? 108 SER B CB 1 ATOM 2777 O OG . SER B 1 88 ? 55.260 -54.146 -8.907 1.00 17.47 ? 108 SER B OG 1 ATOM 2778 N N . ALA B 1 89 ? 54.432 -53.191 -5.979 1.00 17.58 ? 109 ALA B N 1 ATOM 2779 C CA . ALA B 1 89 ? 55.105 -53.181 -4.675 1.00 17.52 ? 109 ALA B CA 1 ATOM 2780 C C . ALA B 1 89 ? 54.087 -52.989 -3.559 1.00 17.53 ? 109 ALA B C 1 ATOM 2781 O O . ALA B 1 89 ? 54.191 -53.640 -2.538 1.00 18.18 ? 109 ALA B O 1 ATOM 2782 C CB . ALA B 1 89 ? 56.198 -52.102 -4.612 1.00 17.01 ? 109 ALA B CB 1 ATOM 2783 N N . ILE B 1 90 ? 53.107 -52.121 -3.755 1.00 16.88 ? 110 ILE B N 1 ATOM 2784 C CA . ILE B 1 90 ? 52.036 -51.983 -2.776 1.00 17.56 ? 110 ILE B CA 1 ATOM 2785 C C . ILE B 1 90 ? 51.324 -53.341 -2.593 1.00 18.46 ? 110 ILE B C 1 ATOM 2786 O O . ILE B 1 90 ? 51.029 -53.731 -1.477 1.00 18.72 ? 110 ILE B O 1 ATOM 2787 C CB . ILE B 1 90 ? 51.030 -50.849 -3.124 1.00 18.57 ? 110 ILE B CB 1 ATOM 2788 C CG1 . ILE B 1 90 ? 51.664 -49.472 -2.949 1.00 18.51 ? 110 ILE B CG1 1 ATOM 2789 C CG2 . ILE B 1 90 ? 49.763 -50.970 -2.258 1.00 20.37 ? 110 ILE B CG2 1 ATOM 2790 C CD1 . ILE B 1 90 ? 52.192 -49.180 -1.540 1.00 18.70 ? 110 ILE B CD1 1 ATOM 2791 N N . GLN B 1 91 ? 51.075 -54.044 -3.675 1.00 18.44 ? 111 GLN B N 1 ATOM 2792 C CA . GLN B 1 91 ? 50.500 -55.389 -3.573 1.00 20.91 ? 111 GLN B CA 1 ATOM 2793 C C . GLN B 1 91 ? 51.340 -56.367 -2.731 1.00 18.94 ? 111 GLN B C 1 ATOM 2794 O O . GLN B 1 91 ? 50.847 -56.960 -1.765 1.00 18.30 ? 111 GLN B O 1 ATOM 2795 C CB . GLN B 1 91 ? 50.260 -55.983 -4.958 1.00 22.67 ? 111 GLN B CB 1 ATOM 2796 C CG . GLN B 1 91 ? 49.721 -57.407 -4.915 1.00 23.96 ? 111 GLN B CG 1 ATOM 2797 C CD . GLN B 1 91 ? 49.550 -58.028 -6.279 1.00 26.04 ? 111 GLN B CD 1 ATOM 2798 O OE1 . GLN B 1 91 ? 50.339 -57.826 -7.187 1.00 28.92 ? 111 GLN B OE1 1 ATOM 2799 N NE2 . GLN B 1 91 ? 48.457 -58.762 -6.440 1.00 28.30 ? 111 GLN B NE2 1 ATOM 2800 N N . ASN B 1 92 ? 52.608 -56.468 -3.101 1.00 19.62 ? 112 ASN B N 1 ATOM 2801 C CA . ASN B 1 92 ? 53.551 -57.345 -2.455 1.00 20.84 ? 112 ASN B CA 1 ATOM 2802 C C . ASN B 1 92 ? 53.678 -57.074 -0.967 1.00 21.35 ? 112 ASN B C 1 ATOM 2803 O O . ASN B 1 92 ? 53.497 -57.968 -0.139 1.00 19.45 ? 112 ASN B O 1 ATOM 2804 C CB . ASN B 1 92 ? 54.924 -57.215 -3.122 1.00 23.87 ? 112 ASN B CB 1 ATOM 2805 C CG . ASN B 1 92 ? 55.902 -58.317 -2.703 1.00 27.96 ? 112 ASN B CG 1 ATOM 2806 O OD1 . ASN B 1 92 ? 55.502 -59.413 -2.386 1.00 32.07 ? 112 ASN B OD1 1 ATOM 2807 N ND2 . ASN B 1 92 ? 57.185 -58.016 -2.729 1.00 34.70 ? 112 ASN B ND2 1 ATOM 2808 N N . TYR B 1 93 ? 53.966 -55.819 -0.632 1.00 20.81 ? 113 TYR B N 1 ATOM 2809 C CA . TYR B 1 93 ? 54.235 -55.436 0.762 1.00 20.54 ? 113 TYR B CA 1 ATOM 2810 C C . TYR B 1 93 ? 52.972 -55.402 1.627 1.00 21.69 ? 113 TYR B C 1 ATOM 2811 O O . TYR B 1 93 ? 53.044 -55.736 2.811 1.00 22.18 ? 113 TYR B O 1 ATOM 2812 C CB . TYR B 1 93 ? 55.092 -54.154 0.870 1.00 19.04 ? 113 TYR B CB 1 ATOM 2813 C CG . TYR B 1 93 ? 56.453 -54.368 0.203 1.00 18.27 ? 113 TYR B CG 1 ATOM 2814 C CD1 . TYR B 1 93 ? 57.323 -55.352 0.670 1.00 19.81 ? 113 TYR B CD1 1 ATOM 2815 C CD2 . TYR B 1 93 ? 56.838 -53.648 -0.928 1.00 17.35 ? 113 TYR B CD2 1 ATOM 2816 C CE1 . TYR B 1 93 ? 58.528 -55.622 0.038 1.00 19.38 ? 113 TYR B CE1 1 ATOM 2817 C CE2 . TYR B 1 93 ? 58.065 -53.849 -1.542 1.00 17.41 ? 113 TYR B CE2 1 ATOM 2818 C CZ . TYR B 1 93 ? 58.897 -54.848 -1.080 1.00 19.04 ? 113 TYR B CZ 1 ATOM 2819 O OH . TYR B 1 93 ? 60.080 -55.109 -1.714 1.00 19.08 ? 113 TYR B OH 1 ATOM 2820 N N . THR B 1 94 ? 51.832 -55.077 1.033 1.00 20.50 ? 114 THR B N 1 ATOM 2821 C CA . THR B 1 94 ? 50.561 -55.152 1.764 1.00 19.96 ? 114 THR B CA 1 ATOM 2822 C C . THR B 1 94 ? 50.277 -56.611 2.115 1.00 19.47 ? 114 THR B C 1 ATOM 2823 O O . THR B 1 94 ? 49.935 -56.913 3.243 1.00 19.84 ? 114 THR B O 1 ATOM 2824 C CB . THR B 1 94 ? 49.363 -54.552 0.992 1.00 20.18 ? 114 THR B CB 1 ATOM 2825 O OG1 . THR B 1 94 ? 49.600 -53.163 0.759 1.00 19.80 ? 114 THR B OG1 1 ATOM 2826 C CG2 . THR B 1 94 ? 48.067 -54.700 1.790 1.00 21.56 ? 114 THR B CG2 1 ATOM 2827 N N . ASN B 1 95 ? 50.430 -57.496 1.148 1.00 20.17 ? 115 ASN B N 1 ATOM 2828 C CA . ASN B 1 95 ? 50.167 -58.905 1.371 1.00 20.94 ? 115 ASN B CA 1 ATOM 2829 C C . ASN B 1 95 ? 51.086 -59.554 2.400 1.00 23.16 ? 115 ASN B C 1 ATOM 2830 O O . ASN B 1 95 ? 50.619 -60.333 3.212 1.00 24.13 ? 115 ASN B O 1 ATOM 2831 C CB . ASN B 1 95 ? 50.099 -59.653 0.044 1.00 22.99 ? 115 ASN B CB 1 ATOM 2832 C CG . ASN B 1 95 ? 48.806 -59.347 -0.708 1.00 23.46 ? 115 ASN B CG 1 ATOM 2833 O OD1 . ASN B 1 95 ? 47.862 -58.805 -0.143 1.00 23.80 ? 115 ASN B OD1 1 ATOM 2834 N ND2 . ASN B 1 95 ? 48.785 -59.621 -1.981 1.00 24.71 ? 115 ASN B ND2 1 ATOM 2835 N N . ILE B 1 96 ? 52.372 -59.192 2.389 1.00 23.06 ? 116 ILE B N 1 ATOM 2836 C CA . ILE B 1 96 ? 53.286 -59.600 3.421 1.00 23.35 ? 116 ILE B CA 1 ATOM 2837 C C . ILE B 1 96 ? 52.749 -59.208 4.785 1.00 25.24 ? 116 ILE B C 1 ATOM 2838 O O . ILE B 1 96 ? 52.800 -60.016 5.726 1.00 26.47 ? 116 ILE B O 1 ATOM 2839 C CB . ILE B 1 96 ? 54.697 -59.046 3.190 1.00 24.18 ? 116 ILE B CB 1 ATOM 2840 C CG1 . ILE B 1 96 ? 55.380 -59.816 2.050 1.00 23.10 ? 116 ILE B CG1 1 ATOM 2841 C CG2 . ILE B 1 96 ? 55.546 -59.122 4.460 1.00 26.87 ? 116 ILE B CG2 1 ATOM 2842 C CD1 . ILE B 1 96 ? 56.569 -59.100 1.424 1.00 24.40 ? 116 ILE B CD1 1 ATOM 2843 N N . LEU B 1 97 ? 52.284 -57.978 4.914 1.00 21.04 ? 117 LEU B N 1 ATOM 2844 C CA . LEU B 1 97 ? 51.790 -57.517 6.188 1.00 21.44 ? 117 LEU B CA 1 ATOM 2845 C C . LEU B 1 97 ? 50.461 -58.170 6.618 1.00 24.06 ? 117 LEU B C 1 ATOM 2846 O O . LEU B 1 97 ? 50.163 -58.240 7.832 1.00 26.59 ? 117 LEU B O 1 ATOM 2847 C CB . LEU B 1 97 ? 51.649 -56.018 6.191 1.00 21.01 ? 117 LEU B CB 1 ATOM 2848 C CG . LEU B 1 97 ? 52.966 -55.233 6.220 1.00 21.29 ? 117 LEU B CG 1 ATOM 2849 C CD1 . LEU B 1 97 ? 52.747 -53.779 5.789 1.00 22.25 ? 117 LEU B CD1 1 ATOM 2850 C CD2 . LEU B 1 97 ? 53.581 -55.263 7.598 1.00 22.91 ? 117 LEU B CD2 1 ATOM 2851 N N . LEU B 1 98 ? 49.670 -58.600 5.632 1.00 23.37 ? 118 LEU B N 1 ATOM 2852 C CA . LEU B 1 98 ? 48.420 -59.301 5.894 1.00 26.62 ? 118 LEU B CA 1 ATOM 2853 C C . LEU B 1 98 ? 48.672 -60.738 6.305 1.00 28.52 ? 118 LEU B C 1 ATOM 2854 O O . LEU B 1 98 ? 48.011 -61.232 7.187 1.00 31.60 ? 118 LEU B O 1 ATOM 2855 C CB . LEU B 1 98 ? 47.470 -59.321 4.653 1.00 24.74 ? 118 LEU B CB 1 ATOM 2856 C CG . LEU B 1 98 ? 46.883 -57.940 4.343 1.00 23.04 ? 118 LEU B CG 1 ATOM 2857 C CD1 . LEU B 1 98 ? 46.134 -57.984 3.019 1.00 23.60 ? 118 LEU B CD1 1 ATOM 2858 C CD2 . LEU B 1 98 ? 46.005 -57.413 5.455 1.00 20.40 ? 118 LEU B CD2 1 ATOM 2859 N N . GLU B 1 99 ? 49.609 -61.392 5.635 1.00 31.42 ? 119 GLU B N 1 ATOM 2860 C CA . GLU B 1 99 ? 49.829 -62.830 5.812 1.00 32.19 ? 119 GLU B CA 1 ATOM 2861 C C . GLU B 1 99 ? 50.810 -63.139 6.947 1.00 34.75 ? 119 GLU B C 1 ATOM 2862 O O . GLU B 1 99 ? 50.734 -64.212 7.535 1.00 34.86 ? 119 GLU B O 1 ATOM 2863 C CB . GLU B 1 99 ? 50.316 -63.421 4.504 1.00 33.80 ? 119 GLU B CB 1 ATOM 2864 C CG . GLU B 1 99 ? 49.310 -63.178 3.349 1.00 35.04 ? 119 GLU B CG 1 ATOM 2865 C CD . GLU B 1 99 ? 49.696 -63.754 1.996 0.50 35.72 ? 119 GLU B CD 1 ATOM 2866 O OE1 . GLU B 1 99 ? 48.890 -63.656 1.044 0.50 37.33 ? 119 GLU B OE1 1 ATOM 2867 O OE2 . GLU B 1 99 ? 50.792 -64.305 1.878 0.50 36.55 ? 119 GLU B OE2 1 ATOM 2868 N N . SER B 1 100 ? 51.739 -62.216 7.218 1.00 31.82 ? 120 SER B N 1 ATOM 2869 C CA . SER B 1 100 ? 52.894 -62.451 8.102 1.00 30.13 ? 120 SER B CA 1 ATOM 2870 C C . SER B 1 100 ? 53.349 -61.213 8.828 1.00 27.64 ? 120 SER B C 1 ATOM 2871 O O . SER B 1 100 ? 54.506 -60.821 8.756 1.00 28.95 ? 120 SER B O 1 ATOM 2872 C CB . SER B 1 100 ? 54.101 -62.989 7.335 1.00 30.92 ? 120 SER B CB 1 ATOM 2873 O OG . SER B 1 100 ? 53.690 -63.951 6.386 1.00 37.00 ? 120 SER B OG 1 ATOM 2874 N N . PRO B 1 101 ? 52.450 -60.591 9.576 1.00 28.88 ? 121 PRO B N 1 ATOM 2875 C CA . PRO B 1 101 ? 52.857 -59.381 10.260 1.00 29.98 ? 121 PRO B CA 1 ATOM 2876 C C . PRO B 1 101 ? 53.966 -59.580 11.307 1.00 33.10 ? 121 PRO B C 1 ATOM 2877 O O . PRO B 1 101 ? 54.506 -58.593 11.780 1.00 31.17 ? 121 PRO B O 1 ATOM 2878 C CB . PRO B 1 101 ? 51.561 -58.918 10.940 1.00 28.27 ? 121 PRO B CB 1 ATOM 2879 C CG . PRO B 1 101 ? 50.751 -60.153 11.097 1.00 29.63 ? 121 PRO B CG 1 ATOM 2880 C CD . PRO B 1 101 ? 51.059 -60.964 9.886 1.00 28.69 ? 121 PRO B CD 1 ATOM 2881 N N . ASN B 1 102 ? 54.200 -60.823 11.743 1.00 36.43 ? 122 ASN B N 1 ATOM 2882 C CA . ASN B 1 102 ? 55.207 -61.117 12.778 1.00 39.18 ? 122 ASN B CA 1 ATOM 2883 C C . ASN B 1 102 ? 56.478 -61.693 12.211 1.00 37.09 ? 122 ASN B C 1 ATOM 2884 O O . ASN B 1 102 ? 57.430 -61.884 12.939 1.00 40.12 ? 122 ASN B O 1 ATOM 2885 C CB . ASN B 1 102 ? 54.633 -62.041 13.869 1.00 39.07 ? 122 ASN B CB 1 ATOM 2886 C CG . ASN B 1 102 ? 53.442 -61.424 14.567 1.00 42.51 ? 122 ASN B CG 1 ATOM 2887 O OD1 . ASN B 1 102 ? 53.496 -60.284 15.071 1.00 47.06 ? 122 ASN B OD1 1 ATOM 2888 N ND2 . ASN B 1 102 ? 52.337 -62.134 14.556 1.00 43.37 ? 122 ASN B ND2 1 ATOM 2889 N N . GLY B 1 103 ? 56.493 -61.937 10.915 1.00 32.85 ? 123 GLY B N 1 ATOM 2890 C CA . GLY B 1 103 ? 57.666 -62.491 10.252 1.00 33.45 ? 123 GLY B CA 1 ATOM 2891 C C . GLY B 1 103 ? 58.751 -61.433 10.036 1.00 33.95 ? 123 GLY B C 1 ATOM 2892 O O . GLY B 1 103 ? 58.566 -60.227 10.296 1.00 33.68 ? 123 GLY B O 1 ATOM 2893 N N . SER B 1 104 ? 59.852 -61.903 9.475 1.00 33.74 ? 124 SER B N 1 ATOM 2894 C CA . SER B 1 104 ? 61.048 -61.082 9.309 1.00 36.21 ? 124 SER B CA 1 ATOM 2895 C C . SER B 1 104 ? 60.927 -60.022 8.175 1.00 34.32 ? 124 SER B C 1 ATOM 2896 O O . SER B 1 104 ? 61.604 -59.007 8.218 1.00 36.98 ? 124 SER B O 1 ATOM 2897 C CB . SER B 1 104 ? 62.277 -61.950 9.076 1.00 33.92 ? 124 SER B CB 1 ATOM 2898 O OG . SER B 1 104 ? 62.236 -62.575 7.805 1.00 34.64 ? 124 SER B OG 1 ATOM 2899 N N . GLU B 1 105 ? 59.991 -60.234 7.263 1.00 31.57 ? 125 GLU B N 1 ATOM 2900 C CA . GLU B 1 105 ? 59.770 -59.299 6.164 1.00 29.82 ? 125 GLU B CA 1 ATOM 2901 C C . GLU B 1 105 ? 58.840 -58.131 6.558 1.00 28.80 ? 125 GLU B C 1 ATOM 2902 O O . GLU B 1 105 ? 58.781 -57.154 5.830 1.00 27.81 ? 125 GLU B O 1 ATOM 2903 C CB . GLU B 1 105 ? 59.221 -60.002 4.911 1.00 30.54 ? 125 GLU B CB 1 ATOM 2904 C CG . GLU B 1 105 ? 60.265 -60.764 4.077 1.00 33.66 ? 125 GLU B CG 1 ATOM 2905 C CD . GLU B 1 105 ? 59.706 -61.436 2.819 0.50 33.10 ? 125 GLU B CD 1 ATOM 2906 O OE1 . GLU B 1 105 ? 58.571 -61.936 2.843 0.50 31.02 ? 125 GLU B OE1 1 ATOM 2907 O OE2 . GLU B 1 105 ? 60.433 -61.504 1.812 0.50 34.19 ? 125 GLU B OE2 1 ATOM 2908 N N . ALA B 1 106 ? 58.167 -58.174 7.710 1.00 26.42 ? 126 ALA B N 1 ATOM 2909 C CA . ALA B 1 106 ? 57.151 -57.148 8.024 1.00 25.77 ? 126 ALA B CA 1 ATOM 2910 C C . ALA B 1 106 ? 57.706 -55.735 8.191 1.00 24.53 ? 126 ALA B C 1 ATOM 2911 O O . ALA B 1 106 ? 57.073 -54.737 7.802 1.00 23.14 ? 126 ALA B O 1 ATOM 2912 C CB . ALA B 1 106 ? 56.320 -57.528 9.256 1.00 25.94 ? 126 ALA B CB 1 ATOM 2913 N N . LEU B 1 107 ? 58.857 -55.654 8.855 1.00 23.21 ? 127 LEU B N 1 ATOM 2914 C CA . LEU B 1 107 ? 59.465 -54.382 9.124 1.00 23.35 ? 127 LEU B CA 1 ATOM 2915 C C . LEU B 1 107 ? 59.694 -53.614 7.794 1.00 21.51 ? 127 LEU B C 1 ATOM 2916 O O . LEU B 1 107 ? 59.314 -52.454 7.676 1.00 20.62 ? 127 LEU B O 1 ATOM 2917 C CB . LEU B 1 107 ? 60.800 -54.588 9.835 1.00 24.69 ? 127 LEU B CB 1 ATOM 2918 C CG . LEU B 1 107 ? 61.711 -53.357 9.898 1.00 27.19 ? 127 LEU B CG 1 ATOM 2919 C CD1 . LEU B 1 107 ? 61.039 -52.232 10.663 1.00 26.13 ? 127 LEU B CD1 1 ATOM 2920 C CD2 . LEU B 1 107 ? 63.066 -53.703 10.552 1.00 29.29 ? 127 LEU B CD2 1 ATOM 2921 N N . ASN B 1 108 ? 60.386 -54.240 6.841 1.00 20.10 ? 128 ASN B N 1 ATOM 2922 C CA . ASN B 1 108 ? 60.685 -53.547 5.570 1.00 20.29 ? 128 ASN B CA 1 ATOM 2923 C C . ASN B 1 108 ? 59.402 -53.301 4.758 1.00 18.92 ? 128 ASN B C 1 ATOM 2924 O O . ASN B 1 108 ? 59.221 -52.230 4.160 1.00 17.48 ? 128 ASN B O 1 ATOM 2925 C CB . ASN B 1 108 ? 61.734 -54.275 4.755 1.00 19.18 ? 128 ASN B CB 1 ATOM 2926 C CG . ASN B 1 108 ? 63.133 -54.075 5.306 1.00 20.94 ? 128 ASN B CG 1 ATOM 2927 O OD1 . ASN B 1 108 ? 63.355 -53.386 6.307 1.00 21.28 ? 128 ASN B OD1 1 ATOM 2928 N ND2 . ASN B 1 108 ? 64.086 -54.670 4.639 1.00 20.85 ? 128 ASN B ND2 1 ATOM 2929 N N . ALA B 1 109 ? 58.504 -54.268 4.791 1.00 18.50 ? 129 ALA B N 1 ATOM 2930 C CA . ALA B 1 109 ? 57.178 -54.118 4.134 1.00 18.27 ? 129 ALA B CA 1 ATOM 2931 C C . ALA B 1 109 ? 56.411 -52.878 4.626 1.00 19.09 ? 129 ALA B C 1 ATOM 2932 O O . ALA B 1 109 ? 55.866 -52.109 3.802 1.00 19.11 ? 129 ALA B O 1 ATOM 2933 C CB . ALA B 1 109 ? 56.334 -55.351 4.262 1.00 18.23 ? 129 ALA B CB 1 ATOM 2934 N N . LEU B 1 110 ? 56.413 -52.640 5.940 1.00 18.10 ? 130 LEU B N 1 ATOM 2935 C CA . LEU B 1 110 ? 55.730 -51.475 6.487 1.00 18.19 ? 130 LEU B CA 1 ATOM 2936 C C . LEU B 1 110 ? 56.430 -50.180 6.099 1.00 18.15 ? 130 LEU B C 1 ATOM 2937 O O . LEU B 1 110 ? 55.760 -49.208 5.678 1.00 16.68 ? 130 LEU B O 1 ATOM 2938 C CB . LEU B 1 110 ? 55.548 -51.588 7.990 1.00 19.85 ? 130 LEU B CB 1 ATOM 2939 C CG . LEU B 1 110 ? 54.921 -50.403 8.718 1.00 20.57 ? 130 LEU B CG 1 ATOM 2940 C CD1 . LEU B 1 110 ? 53.560 -50.082 8.134 1.00 21.55 ? 130 LEU B CD1 1 ATOM 2941 C CD2 . LEU B 1 110 ? 54.766 -50.781 10.201 1.00 23.02 ? 130 LEU B CD2 1 ATOM 2942 N N . LYS B 1 111 ? 57.769 -50.186 6.128 1.00 17.01 ? 131 LYS B N 1 ATOM 2943 C CA . LYS B 1 111 ? 58.501 -49.013 5.694 1.00 17.45 ? 131 LYS B CA 1 ATOM 2944 C C . LYS B 1 111 ? 58.253 -48.690 4.183 1.00 16.32 ? 131 LYS B C 1 ATOM 2945 O O . LYS B 1 111 ? 58.123 -47.542 3.792 1.00 14.48 ? 131 LYS B O 1 ATOM 2946 C CB . LYS B 1 111 ? 59.985 -49.167 6.002 1.00 20.19 ? 131 LYS B CB 1 ATOM 2947 C CG . LYS B 1 111 ? 60.250 -49.291 7.482 1.00 21.87 ? 131 LYS B CG 1 ATOM 2948 C CD . LYS B 1 111 ? 61.699 -49.048 7.835 1.00 25.06 ? 131 LYS B CD 1 ATOM 2949 C CE . LYS B 1 111 ? 62.562 -50.215 7.618 1.00 30.57 ? 131 LYS B CE 1 ATOM 2950 N NZ . LYS B 1 111 ? 63.830 -49.913 8.380 1.00 35.31 ? 131 LYS B NZ 1 ATOM 2951 N N . PHE B 1 112 ? 58.192 -49.717 3.377 1.00 15.57 ? 132 PHE B N 1 ATOM 2952 C CA . PHE B 1 112 ? 57.857 -49.549 1.963 1.00 17.00 ? 132 PHE B CA 1 ATOM 2953 C C . PHE B 1 112 ? 56.471 -48.934 1.729 1.00 16.47 ? 132 PHE B C 1 ATOM 2954 O O . PHE B 1 112 ? 56.326 -48.039 0.914 1.00 15.30 ? 132 PHE B O 1 ATOM 2955 C CB . PHE B 1 112 ? 57.926 -50.890 1.229 1.00 17.65 ? 132 PHE B CB 1 ATOM 2956 C CG . PHE B 1 112 ? 59.307 -51.239 0.728 1.00 17.32 ? 132 PHE B CG 1 ATOM 2957 C CD1 . PHE B 1 112 ? 60.003 -50.386 -0.142 1.00 18.31 ? 132 PHE B CD1 1 ATOM 2958 C CD2 . PHE B 1 112 ? 59.858 -52.458 1.039 1.00 18.58 ? 132 PHE B CD2 1 ATOM 2959 C CE1 . PHE B 1 112 ? 61.265 -50.720 -0.625 1.00 18.76 ? 132 PHE B CE1 1 ATOM 2960 C CE2 . PHE B 1 112 ? 61.105 -52.813 0.563 1.00 19.13 ? 132 PHE B CE2 1 ATOM 2961 C CZ . PHE B 1 112 ? 61.798 -51.961 -0.301 1.00 20.02 ? 132 PHE B CZ 1 ATOM 2962 N N . VAL B 1 113 ? 55.475 -49.459 2.430 1.00 16.98 ? 133 VAL B N 1 ATOM 2963 C CA . VAL B 1 113 ? 54.065 -48.979 2.289 1.00 17.97 ? 133 VAL B CA 1 ATOM 2964 C C . VAL B 1 113 ? 53.968 -47.495 2.670 1.00 17.26 ? 133 VAL B C 1 ATOM 2965 O O . VAL B 1 113 ? 53.370 -46.696 1.934 1.00 16.20 ? 133 VAL B O 1 ATOM 2966 C CB . VAL B 1 113 ? 53.072 -49.830 3.107 1.00 17.86 ? 133 VAL B CB 1 ATOM 2967 C CG1 . VAL B 1 113 ? 51.683 -49.174 3.227 1.00 18.15 ? 133 VAL B CG1 1 ATOM 2968 C CG2 . VAL B 1 113 ? 52.967 -51.194 2.476 1.00 17.91 ? 133 VAL B CG2 1 ATOM 2969 N N . VAL B 1 114 ? 54.618 -47.128 3.783 1.00 16.12 ? 134 VAL B N 1 ATOM 2970 C CA . VAL B 1 114 ? 54.601 -45.761 4.218 1.00 14.59 ? 134 VAL B CA 1 ATOM 2971 C C . VAL B 1 114 ? 55.198 -44.863 3.125 1.00 15.13 ? 134 VAL B C 1 ATOM 2972 O O . VAL B 1 114 ? 54.690 -43.743 2.851 1.00 14.61 ? 134 VAL B O 1 ATOM 2973 C CB . VAL B 1 114 ? 55.373 -45.604 5.535 1.00 16.30 ? 134 VAL B CB 1 ATOM 2974 C CG1 . VAL B 1 114 ? 55.631 -44.126 5.849 1.00 15.02 ? 134 VAL B CG1 1 ATOM 2975 C CG2 . VAL B 1 114 ? 54.664 -46.287 6.695 1.00 16.21 ? 134 VAL B CG2 1 ATOM 2976 N N . HIS B 1 115 ? 56.356 -45.261 2.590 1.00 13.98 ? 135 HIS B N 1 ATOM 2977 C CA . HIS B 1 115 ? 57.044 -44.439 1.575 1.00 13.21 ? 135 HIS B CA 1 ATOM 2978 C C . HIS B 1 115 ? 56.278 -44.371 0.271 1.00 12.75 ? 135 HIS B C 1 ATOM 2979 O O . HIS B 1 115 ? 56.065 -43.298 -0.302 1.00 11.07 ? 135 HIS B O 1 ATOM 2980 C CB . HIS B 1 115 ? 58.499 -44.948 1.328 1.00 13.77 ? 135 HIS B CB 1 ATOM 2981 C CG . HIS B 1 115 ? 59.266 -44.127 0.357 1.00 14.06 ? 135 HIS B CG 1 ATOM 2982 N ND1 . HIS B 1 115 ? 59.967 -43.002 0.739 1.00 14.35 ? 135 HIS B ND1 1 ATOM 2983 C CD2 . HIS B 1 115 ? 59.405 -44.225 -0.988 1.00 14.79 ? 135 HIS B CD2 1 ATOM 2984 C CE1 . HIS B 1 115 ? 60.543 -42.457 -0.316 1.00 16.25 ? 135 HIS B CE1 1 ATOM 2985 N NE2 . HIS B 1 115 ? 60.220 -43.180 -1.386 1.00 15.95 ? 135 HIS B NE2 1 ATOM 2986 N N . ILE B 1 116 ? 55.877 -45.537 -0.191 1.00 12.21 ? 136 ILE B N 1 ATOM 2987 C CA . ILE B 1 116 ? 55.351 -45.665 -1.533 1.00 13.41 ? 136 ILE B CA 1 ATOM 2988 C C . ILE B 1 116 ? 53.933 -45.065 -1.685 1.00 14.19 ? 136 ILE B C 1 ATOM 2989 O O . ILE B 1 116 ? 53.659 -44.423 -2.684 1.00 13.21 ? 136 ILE B O 1 ATOM 2990 C CB . ILE B 1 116 ? 55.420 -47.108 -2.032 1.00 14.00 ? 136 ILE B CB 1 ATOM 2991 C CG1 . ILE B 1 116 ? 56.873 -47.513 -2.185 1.00 13.73 ? 136 ILE B CG1 1 ATOM 2992 C CG2 . ILE B 1 116 ? 54.747 -47.267 -3.401 1.00 14.63 ? 136 ILE B CG2 1 ATOM 2993 C CD1 . ILE B 1 116 ? 57.069 -48.996 -2.369 1.00 13.75 ? 136 ILE B CD1 1 ATOM 2994 N N . ILE B 1 117 ? 53.072 -45.194 -0.666 1.00 13.79 ? 137 ILE B N 1 ATOM 2995 C CA . ILE B 1 117 ? 51.824 -44.485 -0.720 1.00 14.18 ? 137 ILE B CA 1 ATOM 2996 C C . ILE B 1 117 ? 52.081 -42.987 -0.895 1.00 14.01 ? 137 ILE B C 1 ATOM 2997 O O . ILE B 1 117 ? 51.407 -42.341 -1.689 1.00 14.46 ? 137 ILE B O 1 ATOM 2998 C CB . ILE B 1 117 ? 50.850 -44.851 0.440 1.00 15.59 ? 137 ILE B CB 1 ATOM 2999 C CG1 . ILE B 1 117 ? 50.377 -46.295 0.233 1.00 17.24 ? 137 ILE B CG1 1 ATOM 3000 C CG2 . ILE B 1 117 ? 49.658 -43.913 0.463 1.00 15.35 ? 137 ILE B CG2 1 ATOM 3001 C CD1 . ILE B 1 117 ? 49.461 -46.811 1.338 1.00 17.32 ? 137 ILE B CD1 1 ATOM 3002 N N . GLY B 1 118 ? 53.111 -42.439 -0.210 1.00 13.40 ? 138 GLY B N 1 ATOM 3003 C CA . GLY B 1 118 ? 53.487 -41.056 -0.434 1.00 12.95 ? 138 GLY B CA 1 ATOM 3004 C C . GLY B 1 118 ? 53.883 -40.792 -1.891 1.00 12.91 ? 138 GLY B C 1 ATOM 3005 O O . GLY B 1 118 ? 53.341 -39.889 -2.570 1.00 13.68 ? 138 GLY B O 1 ATOM 3006 N N . ASP B 1 119 ? 54.785 -41.608 -2.401 1.00 12.37 ? 139 ASP B N 1 ATOM 3007 C CA . ASP B 1 119 ? 55.319 -41.398 -3.768 1.00 12.53 ? 139 ASP B CA 1 ATOM 3008 C C . ASP B 1 119 ? 54.253 -41.466 -4.855 1.00 12.22 ? 139 ASP B C 1 ATOM 3009 O O . ASP B 1 119 ? 54.284 -40.677 -5.820 1.00 12.32 ? 139 ASP B O 1 ATOM 3010 C CB . ASP B 1 119 ? 56.387 -42.447 -4.069 1.00 11.88 ? 139 ASP B CB 1 ATOM 3011 C CG . ASP B 1 119 ? 57.802 -41.991 -3.789 1.00 12.29 ? 139 ASP B CG 1 ATOM 3012 O OD1 . ASP B 1 119 ? 58.063 -40.799 -3.515 1.00 10.51 ? 139 ASP B OD1 1 ATOM 3013 O OD2 . ASP B 1 119 ? 58.680 -42.917 -3.932 1.00 12.43 ? 139 ASP B OD2 1 ATOM 3014 N N . ILE B 1 120 ? 53.316 -42.394 -4.711 1.00 12.37 ? 140 ILE B N 1 ATOM 3015 C CA . ILE B 1 120 ? 52.194 -42.510 -5.684 1.00 12.64 ? 140 ILE B CA 1 ATOM 3016 C C . ILE B 1 120 ? 51.465 -41.174 -5.888 1.00 12.72 ? 140 ILE B C 1 ATOM 3017 O O . ILE B 1 120 ? 50.943 -40.878 -6.986 1.00 12.45 ? 140 ILE B O 1 ATOM 3018 C CB . ILE B 1 120 ? 51.226 -43.652 -5.283 1.00 13.91 ? 140 ILE B CB 1 ATOM 3019 C CG1 . ILE B 1 120 ? 51.904 -44.985 -5.495 1.00 14.74 ? 140 ILE B CG1 1 ATOM 3020 C CG2 . ILE B 1 120 ? 49.882 -43.579 -6.036 1.00 13.44 ? 140 ILE B CG2 1 ATOM 3021 C CD1 . ILE B 1 120 ? 51.194 -46.157 -4.787 1.00 17.10 ? 140 ILE B CD1 1 ATOM 3022 N N . HIS B 1 121 ? 51.336 -40.411 -4.814 1.00 12.44 ? 141 HIS B N 1 ATOM 3023 C CA . HIS B 1 121 ? 50.652 -39.132 -4.832 1.00 12.27 ? 141 HIS B CA 1 ATOM 3024 C C . HIS B 1 121 ? 51.442 -37.983 -5.424 1.00 12.23 ? 141 HIS B C 1 ATOM 3025 O O . HIS B 1 121 ? 50.890 -36.889 -5.552 1.00 12.44 ? 141 HIS B O 1 ATOM 3026 C CB . HIS B 1 121 ? 50.117 -38.792 -3.460 1.00 12.76 ? 141 HIS B CB 1 ATOM 3027 C CG . HIS B 1 121 ? 48.951 -39.633 -3.074 1.00 13.47 ? 141 HIS B CG 1 ATOM 3028 N ND1 . HIS B 1 121 ? 49.093 -40.926 -2.609 1.00 13.98 ? 141 HIS B ND1 1 ATOM 3029 C CD2 . HIS B 1 121 ? 47.622 -39.421 -3.210 1.00 13.66 ? 141 HIS B CD2 1 ATOM 3030 C CE1 . HIS B 1 121 ? 47.895 -41.447 -2.410 1.00 14.48 ? 141 HIS B CE1 1 ATOM 3031 N NE2 . HIS B 1 121 ? 46.990 -40.536 -2.742 1.00 14.77 ? 141 HIS B NE2 1 ATOM 3032 N N . GLN B 1 122 ? 52.715 -38.206 -5.760 1.00 11.72 ? 142 GLN B N 1 ATOM 3033 C CA . GLN B 1 122 ? 53.512 -37.212 -6.433 1.00 12.58 ? 142 GLN B CA 1 ATOM 3034 C C . GLN B 1 122 ? 53.225 -37.472 -7.944 1.00 12.35 ? 142 GLN B C 1 ATOM 3035 O O . GLN B 1 122 ? 53.640 -38.506 -8.453 1.00 10.94 ? 142 GLN B O 1 ATOM 3036 C CB . GLN B 1 122 ? 55.018 -37.334 -6.085 1.00 12.47 ? 142 GLN B CB 1 ATOM 3037 C CG . GLN B 1 122 ? 55.861 -36.077 -6.217 1.00 11.64 ? 142 GLN B CG 1 ATOM 3038 C CD . GLN B 1 122 ? 56.191 -35.674 -7.676 1.00 12.78 ? 142 GLN B CD 1 ATOM 3039 O OE1 . GLN B 1 122 ? 55.298 -35.390 -8.490 1.00 13.32 ? 142 GLN B OE1 1 ATOM 3040 N NE2 . GLN B 1 122 ? 57.480 -35.636 -8.006 1.00 13.42 ? 142 GLN B NE2 1 ATOM 3041 N N . PRO B 1 123 ? 52.553 -36.511 -8.645 1.00 11.64 ? 143 PRO B N 1 ATOM 3042 C CA . PRO B 1 123 ? 52.061 -36.804 -10.001 1.00 11.80 ? 143 PRO B CA 1 ATOM 3043 C C . PRO B 1 123 ? 53.150 -37.315 -10.976 1.00 11.38 ? 143 PRO B C 1 ATOM 3044 O O . PRO B 1 123 ? 52.851 -38.202 -11.737 1.00 11.37 ? 143 PRO B O 1 ATOM 3045 C CB . PRO B 1 123 ? 51.531 -35.441 -10.482 1.00 12.29 ? 143 PRO B CB 1 ATOM 3046 C CG . PRO B 1 123 ? 51.044 -34.782 -9.203 1.00 12.68 ? 143 PRO B CG 1 ATOM 3047 C CD . PRO B 1 123 ? 52.162 -35.134 -8.229 1.00 12.73 ? 143 PRO B CD 1 ATOM 3048 N N . LEU B 1 124 ? 54.373 -36.776 -10.896 1.00 11.17 ? 144 LEU B N 1 ATOM 3049 C CA . LEU B 1 124 ? 55.462 -37.202 -11.776 1.00 11.46 ? 144 LEU B CA 1 ATOM 3050 C C . LEU B 1 124 ? 56.026 -38.564 -11.468 1.00 11.37 ? 144 LEU B C 1 ATOM 3051 O O . LEU B 1 124 ? 56.774 -39.132 -12.284 1.00 13.75 ? 144 LEU B O 1 ATOM 3052 C CB . LEU B 1 124 ? 56.547 -36.138 -11.871 1.00 12.21 ? 144 LEU B CB 1 ATOM 3053 C CG . LEU B 1 124 ? 56.172 -34.931 -12.764 1.00 11.74 ? 144 LEU B CG 1 ATOM 3054 C CD1 . LEU B 1 124 ? 57.158 -33.795 -12.609 1.00 12.03 ? 144 LEU B CD1 1 ATOM 3055 C CD2 . LEU B 1 124 ? 56.061 -35.347 -14.232 1.00 11.92 ? 144 LEU B CD2 1 ATOM 3056 N N . HIS B 1 125 ? 55.552 -39.169 -10.362 1.00 11.42 ? 145 HIS B N 1 ATOM 3057 C CA . HIS B 1 125 ? 55.783 -40.584 -10.070 1.00 11.19 ? 145 HIS B CA 1 ATOM 3058 C C . HIS B 1 125 ? 54.744 -41.485 -10.758 1.00 12.10 ? 145 HIS B C 1 ATOM 3059 O O . HIS B 1 125 ? 54.793 -42.706 -10.579 1.00 10.88 ? 145 HIS B O 1 ATOM 3060 C CB . HIS B 1 125 ? 55.763 -40.861 -8.590 1.00 11.63 ? 145 HIS B CB 1 ATOM 3061 C CG . HIS B 1 125 ? 57.030 -40.505 -7.903 1.00 12.13 ? 145 HIS B CG 1 ATOM 3062 N ND1 . HIS B 1 125 ? 57.842 -41.452 -7.336 1.00 11.36 ? 145 HIS B ND1 1 ATOM 3063 C CD2 . HIS B 1 125 ? 57.657 -39.312 -7.734 1.00 12.12 ? 145 HIS B CD2 1 ATOM 3064 C CE1 . HIS B 1 125 ? 58.918 -40.865 -6.840 1.00 11.89 ? 145 HIS B CE1 1 ATOM 3065 N NE2 . HIS B 1 125 ? 58.842 -39.571 -7.100 1.00 11.39 ? 145 HIS B NE2 1 ATOM 3066 N N . ASP B 1 126 ? 53.857 -40.894 -11.563 1.00 11.27 ? 146 ASP B N 1 ATOM 3067 C CA . ASP B 1 126 ? 52.874 -41.666 -12.334 1.00 12.59 ? 146 ASP B CA 1 ATOM 3068 C C . ASP B 1 126 ? 52.904 -41.211 -13.809 1.00 13.88 ? 146 ASP B C 1 ATOM 3069 O O . ASP B 1 126 ? 51.856 -41.023 -14.437 1.00 13.96 ? 146 ASP B O 1 ATOM 3070 C CB . ASP B 1 126 ? 51.449 -41.440 -11.764 1.00 12.80 ? 146 ASP B CB 1 ATOM 3071 C CG . ASP B 1 126 ? 51.365 -41.691 -10.279 1.00 13.37 ? 146 ASP B CG 1 ATOM 3072 O OD1 . ASP B 1 126 ? 51.317 -42.887 -9.876 1.00 13.70 ? 146 ASP B OD1 1 ATOM 3073 O OD2 . ASP B 1 126 ? 51.324 -40.694 -9.482 1.00 14.13 ? 146 ASP B OD2 1 ATOM 3074 N N . GLU B 1 127 ? 54.120 -41.079 -14.365 1.00 13.48 ? 147 GLU B N 1 ATOM 3075 C CA . GLU B 1 127 ? 54.322 -40.488 -15.664 1.00 13.34 ? 147 GLU B CA 1 ATOM 3076 C C . GLU B 1 127 ? 55.676 -40.916 -16.265 1.00 14.59 ? 147 GLU B C 1 ATOM 3077 O O . GLU B 1 127 ? 56.731 -40.746 -15.648 1.00 14.58 ? 147 GLU B O 1 ATOM 3078 C CB . GLU B 1 127 ? 54.247 -38.976 -15.589 1.00 13.77 ? 147 GLU B CB 1 ATOM 3079 C CG . GLU B 1 127 ? 54.538 -38.220 -16.935 1.00 15.11 ? 147 GLU B CG 1 ATOM 3080 C CD . GLU B 1 127 ? 53.675 -38.759 -18.029 1.00 15.25 ? 147 GLU B CD 1 ATOM 3081 O OE1 . GLU B 1 127 ? 52.461 -38.822 -17.767 1.00 13.86 ? 147 GLU B OE1 1 ATOM 3082 O OE2 . GLU B 1 127 ? 54.221 -39.132 -19.128 1.00 15.35 ? 147 GLU B OE2 1 ATOM 3083 N N . ASN B 1 128 ? 55.625 -41.455 -17.482 1.00 14.86 ? 148 ASN B N 1 ATOM 3084 C CA . ASN B 1 128 ? 56.841 -41.930 -18.171 1.00 14.20 ? 148 ASN B CA 1 ATOM 3085 C C . ASN B 1 128 ? 57.721 -40.799 -18.750 1.00 15.25 ? 148 ASN B C 1 ATOM 3086 O O . ASN B 1 128 ? 58.956 -40.880 -18.628 1.00 15.30 ? 148 ASN B O 1 ATOM 3087 C CB . ASN B 1 128 ? 56.504 -42.892 -19.259 1.00 14.02 ? 148 ASN B CB 1 ATOM 3088 C CG . ASN B 1 128 ? 57.752 -43.561 -19.846 1.00 14.79 ? 148 ASN B CG 1 ATOM 3089 O OD1 . ASN B 1 128 ? 58.500 -44.194 -19.149 1.00 13.45 ? 148 ASN B OD1 1 ATOM 3090 N ND2 . ASN B 1 128 ? 57.980 -43.350 -21.127 1.00 14.41 ? 148 ASN B ND2 1 ATOM 3091 N N . LEU B 1 129 ? 57.087 -39.730 -19.256 1.00 14.53 ? 149 LEU B N 1 ATOM 3092 C CA . LEU B 1 129 ? 57.756 -38.668 -20.047 1.00 15.27 ? 149 LEU B CA 1 ATOM 3093 C C . LEU B 1 129 ? 59.078 -38.175 -19.389 1.00 15.35 ? 149 LEU B C 1 ATOM 3094 O O . LEU B 1 129 ? 59.085 -37.757 -18.215 1.00 12.94 ? 149 LEU B O 1 ATOM 3095 C CB . LEU B 1 129 ? 56.852 -37.451 -20.268 1.00 15.47 ? 149 LEU B CB 1 ATOM 3096 C CG . LEU B 1 129 ? 57.460 -36.291 -21.082 1.00 16.98 ? 149 LEU B CG 1 ATOM 3097 C CD1 . LEU B 1 129 ? 57.738 -36.671 -22.535 1.00 16.40 ? 149 LEU B CD1 1 ATOM 3098 C CD2 . LEU B 1 129 ? 56.562 -35.080 -21.032 1.00 17.26 ? 149 LEU B CD2 1 ATOM 3099 N N . GLU B 1 130 ? 60.176 -38.331 -20.152 1.00 15.25 ? 150 GLU B N 1 ATOM 3100 C CA . GLU B 1 130 ? 61.526 -37.927 -19.731 1.00 16.81 ? 150 GLU B CA 1 ATOM 3101 C C . GLU B 1 130 ? 61.853 -38.361 -18.307 1.00 15.99 ? 150 GLU B C 1 ATOM 3102 O O . GLU B 1 130 ? 62.215 -37.560 -17.445 1.00 16.35 ? 150 GLU B O 1 ATOM 3103 C CB . GLU B 1 130 ? 61.675 -36.406 -19.910 1.00 20.35 ? 150 GLU B CB 1 ATOM 3104 C CG . GLU B 1 130 ? 61.687 -36.037 -21.399 1.00 23.69 ? 150 GLU B CG 1 ATOM 3105 C CD . GLU B 1 130 ? 62.072 -34.591 -21.730 1.00 32.14 ? 150 GLU B CD 1 ATOM 3106 O OE1 . GLU B 1 130 ? 61.244 -33.884 -22.397 1.00 32.45 ? 150 GLU B OE1 1 ATOM 3107 O OE2 . GLU B 1 130 ? 63.176 -34.135 -21.338 1.00 32.91 ? 150 GLU B OE2 1 ATOM 3108 N N . ALA B 1 131 ? 61.703 -39.657 -18.084 1.00 15.06 ? 151 ALA B N 1 ATOM 3109 C CA . ALA B 1 131 ? 61.932 -40.309 -16.799 1.00 15.94 ? 151 ALA B CA 1 ATOM 3110 C C . ALA B 1 131 ? 61.190 -39.605 -15.640 1.00 14.25 ? 151 ALA B C 1 ATOM 3111 O O . ALA B 1 131 ? 61.814 -39.191 -14.684 1.00 14.06 ? 151 ALA B O 1 ATOM 3112 C CB . ALA B 1 131 ? 63.435 -40.406 -16.513 1.00 16.39 ? 151 ALA B CB 1 ATOM 3113 N N . GLY B 1 132 ? 59.868 -39.489 -15.750 1.00 12.46 ? 152 GLY B N 1 ATOM 3114 C CA . GLY B 1 132 ? 59.072 -38.796 -14.741 1.00 13.09 ? 152 GLY B CA 1 ATOM 3115 C C . GLY B 1 132 ? 59.437 -37.327 -14.557 1.00 12.75 ? 152 GLY B C 1 ATOM 3116 O O . GLY B 1 132 ? 59.359 -36.773 -13.463 1.00 13.06 ? 152 GLY B O 1 ATOM 3117 N N . GLY B 1 133 ? 59.805 -36.694 -15.674 1.00 12.72 ? 153 GLY B N 1 ATOM 3118 C CA . GLY B 1 133 ? 60.197 -35.308 -15.658 1.00 13.27 ? 153 GLY B CA 1 ATOM 3119 C C . GLY B 1 133 ? 61.631 -35.067 -15.157 1.00 12.65 ? 153 GLY B C 1 ATOM 3120 O O . GLY B 1 133 ? 62.047 -33.957 -15.126 1.00 12.99 ? 153 GLY B O 1 ATOM 3121 N N . ASN B 1 134 ? 62.358 -36.100 -14.782 1.00 13.39 ? 154 ASN B N 1 ATOM 3122 C CA . ASN B 1 134 ? 63.751 -35.935 -14.353 1.00 14.62 ? 154 ASN B CA 1 ATOM 3123 C C . ASN B 1 134 ? 64.625 -35.364 -15.472 1.00 15.78 ? 154 ASN B C 1 ATOM 3124 O O . ASN B 1 134 ? 65.559 -34.663 -15.207 1.00 15.86 ? 154 ASN B O 1 ATOM 3125 C CB . ASN B 1 134 ? 64.338 -37.245 -13.812 1.00 15.23 ? 154 ASN B CB 1 ATOM 3126 C CG . ASN B 1 134 ? 63.881 -37.518 -12.364 1.00 16.08 ? 154 ASN B CG 1 ATOM 3127 O OD1 . ASN B 1 134 ? 64.382 -36.900 -11.437 1.00 17.17 ? 154 ASN B OD1 1 ATOM 3128 N ND2 . ASN B 1 134 ? 62.962 -38.453 -12.180 1.00 14.92 ? 154 ASN B ND2 1 ATOM 3129 N N . GLY B 1 135 ? 64.281 -35.637 -16.726 1.00 16.69 ? 155 GLY B N 1 ATOM 3130 C CA . GLY B 1 135 ? 65.022 -35.145 -17.896 1.00 18.23 ? 155 GLY B CA 1 ATOM 3131 C C . GLY B 1 135 ? 64.608 -33.781 -18.406 1.00 19.38 ? 155 GLY B C 1 ATOM 3132 O O . GLY B 1 135 ? 65.192 -33.268 -19.345 1.00 20.59 ? 155 GLY B O 1 ATOM 3133 N N . ILE B 1 136 ? 63.620 -33.163 -17.764 1.00 18.34 ? 156 ILE B N 1 ATOM 3134 C CA . ILE B 1 136 ? 63.172 -31.800 -18.150 1.00 18.48 ? 156 ILE B CA 1 ATOM 3135 C C . ILE B 1 136 ? 63.882 -30.752 -17.305 1.00 18.02 ? 156 ILE B C 1 ATOM 3136 O O . ILE B 1 136 ? 63.511 -30.515 -16.159 1.00 17.01 ? 156 ILE B O 1 ATOM 3137 C CB . ILE B 1 136 ? 61.633 -31.644 -18.003 1.00 18.99 ? 156 ILE B CB 1 ATOM 3138 C CG1 . ILE B 1 136 ? 60.930 -32.711 -18.823 1.00 20.43 ? 156 ILE B CG1 1 ATOM 3139 C CG2 . ILE B 1 136 ? 61.175 -30.263 -18.405 1.00 20.52 ? 156 ILE B CG2 1 ATOM 3140 C CD1 . ILE B 1 136 ? 59.417 -32.771 -18.676 1.00 19.74 ? 156 ILE B CD1 1 ATOM 3141 N N . ASP B 1 137 ? 64.842 -30.069 -17.899 1.00 18.66 ? 157 ASP B N 1 ATOM 3142 C CA . ASP B 1 137 ? 65.545 -28.979 -17.233 1.00 20.89 ? 157 ASP B CA 1 ATOM 3143 C C . ASP B 1 137 ? 64.682 -27.773 -17.024 1.00 20.51 ? 157 ASP B C 1 ATOM 3144 O O . ASP B 1 137 ? 63.967 -27.355 -17.927 1.00 20.13 ? 157 ASP B O 1 ATOM 3145 C CB . ASP B 1 137 ? 66.731 -28.489 -18.037 1.00 25.44 ? 157 ASP B CB 1 ATOM 3146 C CG . ASP B 1 137 ? 67.878 -29.466 -18.061 1.00 31.68 ? 157 ASP B CG 1 ATOM 3147 O OD1 . ASP B 1 137 ? 67.806 -30.526 -17.391 1.00 42.52 ? 157 ASP B OD1 1 ATOM 3148 O OD2 . ASP B 1 137 ? 68.872 -29.114 -18.713 1.00 32.22 ? 157 ASP B OD2 1 ATOM 3149 N N . VAL B 1 138 ? 64.772 -27.201 -15.832 1.00 19.24 ? 158 VAL B N 1 ATOM 3150 C CA . VAL B 1 138 ? 64.060 -25.986 -15.506 1.00 18.31 ? 158 VAL B CA 1 ATOM 3151 C C . VAL B 1 138 ? 64.961 -25.036 -14.687 1.00 18.16 ? 158 VAL B C 1 ATOM 3152 O O . VAL B 1 138 ? 65.972 -25.448 -14.136 1.00 19.20 ? 158 VAL B O 1 ATOM 3153 C CB . VAL B 1 138 ? 62.766 -26.301 -14.727 1.00 18.26 ? 158 VAL B CB 1 ATOM 3154 C CG1 . VAL B 1 138 ? 61.888 -27.293 -15.507 1.00 19.03 ? 158 VAL B CG1 1 ATOM 3155 C CG2 . VAL B 1 138 ? 63.029 -26.817 -13.318 1.00 17.91 ? 158 VAL B CG2 1 ATOM 3156 N N . THR B 1 139 ? 64.535 -23.801 -14.572 1.00 18.09 ? 159 THR B N 1 ATOM 3157 C CA . THR B 1 139 ? 65.123 -22.863 -13.660 1.00 19.84 ? 159 THR B CA 1 ATOM 3158 C C . THR B 1 139 ? 64.161 -22.645 -12.524 1.00 19.66 ? 159 THR B C 1 ATOM 3159 O O . THR B 1 139 ? 62.995 -22.402 -12.766 1.00 18.51 ? 159 THR B O 1 ATOM 3160 C CB . THR B 1 139 ? 65.393 -21.505 -14.350 1.00 23.41 ? 159 THR B CB 1 ATOM 3161 O OG1 . THR B 1 139 ? 66.169 -21.741 -15.517 1.00 22.94 ? 159 THR B OG1 1 ATOM 3162 C CG2 . THR B 1 139 ? 66.181 -20.576 -13.428 1.00 26.06 ? 159 THR B CG2 1 ATOM 3163 N N . TYR B 1 140 ? 64.670 -22.737 -11.303 1.00 17.86 ? 160 TYR B N 1 ATOM 3164 C CA . TYR B 1 140 ? 63.903 -22.512 -10.133 1.00 18.96 ? 160 TYR B CA 1 ATOM 3165 C C . TYR B 1 140 ? 64.674 -21.542 -9.238 1.00 22.91 ? 160 TYR B C 1 ATOM 3166 O O . TYR B 1 140 ? 65.765 -21.877 -8.718 1.00 22.85 ? 160 TYR B O 1 ATOM 3167 C CB . TYR B 1 140 ? 63.599 -23.815 -9.347 1.00 17.55 ? 160 TYR B CB 1 ATOM 3168 C CG . TYR B 1 140 ? 62.439 -23.606 -8.399 1.00 17.29 ? 160 TYR B CG 1 ATOM 3169 C CD1 . TYR B 1 140 ? 61.136 -23.765 -8.863 1.00 16.91 ? 160 TYR B CD1 1 ATOM 3170 C CD2 . TYR B 1 140 ? 62.623 -23.214 -7.048 1.00 17.10 ? 160 TYR B CD2 1 ATOM 3171 C CE1 . TYR B 1 140 ? 60.031 -23.573 -8.032 1.00 16.64 ? 160 TYR B CE1 1 ATOM 3172 C CE2 . TYR B 1 140 ? 61.523 -23.007 -6.210 1.00 17.93 ? 160 TYR B CE2 1 ATOM 3173 C CZ . TYR B 1 140 ? 60.230 -23.182 -6.723 1.00 17.36 ? 160 TYR B CZ 1 ATOM 3174 O OH . TYR B 1 140 ? 59.148 -22.978 -5.944 1.00 17.52 ? 160 TYR B OH 1 ATOM 3175 N N . ASP B 1 141 ? 64.101 -20.349 -9.048 1.00 24.78 ? 161 ASP B N 1 ATOM 3176 C CA . ASP B 1 141 ? 64.734 -19.280 -8.279 1.00 26.56 ? 161 ASP B CA 1 ATOM 3177 C C . ASP B 1 141 ? 66.207 -19.057 -8.673 1.00 25.12 ? 161 ASP B C 1 ATOM 3178 O O . ASP B 1 141 ? 67.112 -19.045 -7.849 1.00 27.82 ? 161 ASP B O 1 ATOM 3179 C CB . ASP B 1 141 ? 64.612 -19.613 -6.790 1.00 29.14 ? 161 ASP B CB 1 ATOM 3180 C CG . ASP B 1 141 ? 65.010 -18.436 -5.902 1.00 35.19 ? 161 ASP B CG 1 ATOM 3181 O OD1 . ASP B 1 141 ? 64.948 -17.280 -6.358 1.00 40.53 ? 161 ASP B OD1 1 ATOM 3182 O OD2 . ASP B 1 141 ? 65.393 -18.675 -4.748 1.00 39.39 ? 161 ASP B OD2 1 ATOM 3183 N N . GLY B 1 142 ? 66.449 -18.961 -9.951 1.00 26.28 ? 162 GLY B N 1 ATOM 3184 C CA . GLY B 1 142 ? 67.805 -18.743 -10.472 1.00 26.97 ? 162 GLY B CA 1 ATOM 3185 C C . GLY B 1 142 ? 68.685 -19.981 -10.616 1.00 28.33 ? 162 GLY B C 1 ATOM 3186 O O . GLY B 1 142 ? 69.677 -19.917 -11.275 1.00 30.04 ? 162 GLY B O 1 ATOM 3187 N N . GLU B 1 143 ? 68.325 -21.108 -10.019 1.00 29.12 ? 163 GLU B N 1 ATOM 3188 C CA . GLU B 1 143 ? 69.131 -22.341 -10.129 1.00 29.81 ? 163 GLU B CA 1 ATOM 3189 C C . GLU B 1 143 ? 68.611 -23.277 -11.258 1.00 27.75 ? 163 GLU B C 1 ATOM 3190 O O . GLU B 1 143 ? 67.401 -23.419 -11.433 1.00 23.48 ? 163 GLU B O 1 ATOM 3191 C CB . GLU B 1 143 ? 69.138 -23.082 -8.783 1.00 33.28 ? 163 GLU B CB 1 ATOM 3192 C CG . GLU B 1 143 ? 70.065 -22.423 -7.746 1.00 39.57 ? 163 GLU B CG 1 ATOM 3193 C CD . GLU B 1 143 ? 71.549 -22.526 -8.133 0.50 39.69 ? 163 GLU B CD 1 ATOM 3194 O OE1 . GLU B 1 143 ? 72.107 -23.667 -8.174 0.50 38.71 ? 163 GLU B OE1 1 ATOM 3195 O OE2 . GLU B 1 143 ? 72.144 -21.456 -8.403 0.50 39.09 ? 163 GLU B OE2 1 ATOM 3196 N N . THR B 1 144 ? 69.520 -23.933 -11.968 1.00 23.23 ? 164 THR B N 1 ATOM 3197 C CA . THR B 1 144 ? 69.160 -24.992 -12.882 1.00 23.05 ? 164 THR B CA 1 ATOM 3198 C C . THR B 1 144 ? 68.933 -26.304 -12.155 1.00 21.50 ? 164 THR B C 1 ATOM 3199 O O . THR B 1 144 ? 69.736 -26.713 -11.370 1.00 21.60 ? 164 THR B O 1 ATOM 3200 C CB . THR B 1 144 ? 70.216 -25.207 -13.940 1.00 25.50 ? 164 THR B CB 1 ATOM 3201 O OG1 . THR B 1 144 ? 70.341 -23.998 -14.685 1.00 27.93 ? 164 THR B OG1 1 ATOM 3202 C CG2 . THR B 1 144 ? 69.800 -26.321 -14.911 1.00 25.19 ? 164 THR B CG2 1 ATOM 3203 N N . THR B 1 145 ? 67.772 -26.934 -12.409 1.00 18.90 ? 165 THR B N 1 ATOM 3204 C CA . THR B 1 145 ? 67.392 -28.212 -11.775 1.00 16.60 ? 165 THR B CA 1 ATOM 3205 C C . THR B 1 145 ? 66.502 -28.933 -12.770 1.00 15.43 ? 165 THR B C 1 ATOM 3206 O O . THR B 1 145 ? 66.591 -28.671 -13.986 1.00 15.89 ? 165 THR B O 1 ATOM 3207 C CB . THR B 1 145 ? 66.790 -28.001 -10.343 1.00 17.46 ? 165 THR B CB 1 ATOM 3208 O OG1 . THR B 1 145 ? 66.396 -29.249 -9.744 1.00 18.35 ? 165 THR B OG1 1 ATOM 3209 C CG2 . THR B 1 145 ? 65.627 -27.063 -10.328 1.00 18.79 ? 165 THR B CG2 1 ATOM 3210 N N . ASN B 1 146 ? 65.615 -29.795 -12.312 1.00 15.08 ? 166 ASN B N 1 ATOM 3211 C CA . ASN B 1 146 ? 64.641 -30.417 -13.259 1.00 15.08 ? 166 ASN B CA 1 ATOM 3212 C C . ASN B 1 146 ? 63.230 -30.406 -12.689 1.00 14.52 ? 166 ASN B C 1 ATOM 3213 O O . ASN B 1 146 ? 63.038 -30.190 -11.498 1.00 13.82 ? 166 ASN B O 1 ATOM 3214 C CB . ASN B 1 146 ? 65.117 -31.817 -13.670 1.00 15.25 ? 166 ASN B CB 1 ATOM 3215 C CG . ASN B 1 146 ? 65.103 -32.800 -12.497 1.00 15.66 ? 166 ASN B CG 1 ATOM 3216 O OD1 . ASN B 1 146 ? 64.058 -33.256 -12.068 1.00 15.14 ? 166 ASN B OD1 1 ATOM 3217 N ND2 . ASN B 1 146 ? 66.283 -33.127 -11.970 1.00 15.87 ? 166 ASN B ND2 1 ATOM 3218 N N . LEU B 1 147 ? 62.259 -30.696 -13.568 1.00 14.05 ? 167 LEU B N 1 ATOM 3219 C CA . LEU B 1 147 ? 60.866 -30.585 -13.234 1.00 13.01 ? 167 LEU B CA 1 ATOM 3220 C C . LEU B 1 147 ? 60.498 -31.579 -12.140 1.00 12.87 ? 167 LEU B C 1 ATOM 3221 O O . LEU B 1 147 ? 59.741 -31.248 -11.223 1.00 15.08 ? 167 LEU B O 1 ATOM 3222 C CB . LEU B 1 147 ? 59.973 -30.773 -14.479 1.00 13.63 ? 167 LEU B CB 1 ATOM 3223 C CG . LEU B 1 147 ? 58.490 -30.434 -14.260 1.00 13.87 ? 167 LEU B CG 1 ATOM 3224 C CD1 . LEU B 1 147 ? 58.260 -28.983 -13.905 1.00 14.21 ? 167 LEU B CD1 1 ATOM 3225 C CD2 . LEU B 1 147 ? 57.731 -30.767 -15.514 1.00 14.15 ? 167 LEU B CD2 1 ATOM 3226 N N . HIS B 1 148 ? 61.032 -32.787 -12.182 1.00 12.00 ? 168 HIS B N 1 ATOM 3227 C CA . HIS B 1 148 ? 60.703 -33.760 -11.171 1.00 11.97 ? 168 HIS B CA 1 ATOM 3228 C C . HIS B 1 148 ? 61.185 -33.273 -9.777 1.00 13.40 ? 168 HIS B C 1 ATOM 3229 O O . HIS B 1 148 ? 60.488 -33.364 -8.776 1.00 13.95 ? 168 HIS B O 1 ATOM 3230 C CB . HIS B 1 148 ? 61.344 -35.106 -11.473 1.00 12.01 ? 168 HIS B CB 1 ATOM 3231 C CG . HIS B 1 148 ? 60.942 -36.185 -10.514 1.00 11.59 ? 168 HIS B CG 1 ATOM 3232 N ND1 . HIS B 1 148 ? 60.099 -37.208 -10.873 1.00 11.74 ? 168 HIS B ND1 1 ATOM 3233 C CD2 . HIS B 1 148 ? 61.268 -36.400 -9.207 1.00 11.26 ? 168 HIS B CD2 1 ATOM 3234 C CE1 . HIS B 1 148 ? 59.920 -38.011 -9.828 1.00 11.04 ? 168 HIS B CE1 1 ATOM 3235 N NE2 . HIS B 1 148 ? 60.610 -37.527 -8.811 1.00 11.07 ? 168 HIS B NE2 1 ATOM 3236 N N . HIS B 1 149 ? 62.411 -32.781 -9.786 1.00 14.64 ? 169 HIS B N 1 ATOM 3237 C CA . HIS B 1 149 ? 63.058 -32.294 -8.560 1.00 16.61 ? 169 HIS B CA 1 ATOM 3238 C C . HIS B 1 149 ? 62.278 -31.186 -7.857 1.00 14.27 ? 169 HIS B C 1 ATOM 3239 O O . HIS B 1 149 ? 62.172 -31.171 -6.631 1.00 14.60 ? 169 HIS B O 1 ATOM 3240 C CB . HIS B 1 149 ? 64.497 -31.858 -8.859 1.00 17.08 ? 169 HIS B CB 1 ATOM 3241 C CG . HIS B 1 149 ? 65.326 -31.696 -7.626 1.00 22.66 ? 169 HIS B CG 1 ATOM 3242 N ND1 . HIS B 1 149 ? 65.415 -30.499 -6.937 1.00 24.49 ? 169 HIS B ND1 1 ATOM 3243 C CD2 . HIS B 1 149 ? 66.088 -32.569 -6.945 1.00 25.85 ? 169 HIS B CD2 1 ATOM 3244 C CE1 . HIS B 1 149 ? 66.198 -30.648 -5.890 1.00 25.13 ? 169 HIS B CE1 1 ATOM 3245 N NE2 . HIS B 1 149 ? 66.612 -31.896 -5.864 1.00 28.52 ? 169 HIS B NE2 1 ATOM 3246 N N . ILE B 1 150 ? 61.744 -30.242 -8.639 1.00 14.78 ? 170 ILE B N 1 ATOM 3247 C CA . ILE B 1 150 ? 60.943 -29.178 -8.043 1.00 14.20 ? 170 ILE B CA 1 ATOM 3248 C C . ILE B 1 150 ? 59.617 -29.655 -7.444 1.00 14.08 ? 170 ILE B C 1 ATOM 3249 O O . ILE B 1 150 ? 59.192 -29.138 -6.404 1.00 14.18 ? 170 ILE B O 1 ATOM 3250 C CB . ILE B 1 150 ? 60.762 -27.893 -8.938 1.00 14.45 ? 170 ILE B CB 1 ATOM 3251 C CG1 . ILE B 1 150 ? 59.722 -28.103 -10.051 1.00 15.04 ? 170 ILE B CG1 1 ATOM 3252 C CG2 . ILE B 1 150 ? 62.135 -27.420 -9.427 1.00 14.49 ? 170 ILE B CG2 1 ATOM 3253 C CD1 . ILE B 1 150 ? 59.296 -26.752 -10.656 1.00 15.88 ? 170 ILE B CD1 1 ATOM 3254 N N . TRP B 1 151 ? 58.982 -30.660 -8.058 1.00 13.36 ? 171 TRP B N 1 ATOM 3255 C CA . TRP B 1 151 ? 57.826 -31.312 -7.461 1.00 13.69 ? 171 TRP B CA 1 ATOM 3256 C C . TRP B 1 151 ? 58.178 -32.100 -6.173 1.00 14.90 ? 171 TRP B C 1 ATOM 3257 O O . TRP B 1 151 ? 57.435 -32.070 -5.208 1.00 14.82 ? 171 TRP B O 1 ATOM 3258 C CB . TRP B 1 151 ? 57.053 -32.151 -8.473 1.00 12.56 ? 171 TRP B CB 1 ATOM 3259 C CG . TRP B 1 151 ? 56.169 -31.270 -9.263 1.00 12.85 ? 171 TRP B CG 1 ATOM 3260 C CD1 . TRP B 1 151 ? 56.502 -30.545 -10.375 1.00 12.39 ? 171 TRP B CD1 1 ATOM 3261 C CD2 . TRP B 1 151 ? 54.798 -30.968 -8.996 1.00 13.28 ? 171 TRP B CD2 1 ATOM 3262 N NE1 . TRP B 1 151 ? 55.437 -29.820 -10.796 1.00 13.37 ? 171 TRP B NE1 1 ATOM 3263 C CE2 . TRP B 1 151 ? 54.381 -30.041 -9.962 1.00 12.66 ? 171 TRP B CE2 1 ATOM 3264 C CE3 . TRP B 1 151 ? 53.886 -31.366 -8.013 1.00 13.15 ? 171 TRP B CE3 1 ATOM 3265 C CZ2 . TRP B 1 151 ? 53.072 -29.519 -10.003 1.00 14.21 ? 171 TRP B CZ2 1 ATOM 3266 C CZ3 . TRP B 1 151 ? 52.564 -30.862 -8.081 1.00 13.64 ? 171 TRP B CZ3 1 ATOM 3267 C CH2 . TRP B 1 151 ? 52.189 -29.948 -9.061 1.00 13.38 ? 171 TRP B CH2 1 ATOM 3268 N N . ASP B 1 152 ? 59.317 -32.771 -6.167 1.00 14.28 ? 172 ASP B N 1 ATOM 3269 C CA . ASP B 1 152 ? 59.673 -33.608 -5.017 1.00 15.02 ? 172 ASP B CA 1 ATOM 3270 C C . ASP B 1 152 ? 60.083 -32.740 -3.823 1.00 14.96 ? 172 ASP B C 1 ATOM 3271 O O . ASP B 1 152 ? 59.720 -33.029 -2.704 1.00 16.24 ? 172 ASP B O 1 ATOM 3272 C CB . ASP B 1 152 ? 60.883 -34.542 -5.346 1.00 14.49 ? 172 ASP B CB 1 ATOM 3273 C CG . ASP B 1 152 ? 60.508 -35.924 -5.767 1.00 15.85 ? 172 ASP B CG 1 ATOM 3274 O OD1 . ASP B 1 152 ? 59.321 -36.319 -5.917 1.00 14.85 ? 172 ASP B OD1 1 ATOM 3275 O OD2 . ASP B 1 152 ? 61.464 -36.696 -6.033 1.00 16.13 ? 172 ASP B OD2 1 ATOM 3276 N N . THR B 1 153 ? 60.798 -31.673 -4.122 1.00 15.38 ? 173 THR B N 1 ATOM 3277 C CA . THR B 1 153 ? 61.655 -30.992 -3.163 1.00 15.62 ? 173 THR B CA 1 ATOM 3278 C C . THR B 1 153 ? 61.527 -29.465 -3.144 1.00 16.38 ? 173 THR B C 1 ATOM 3279 O O . THR B 1 153 ? 61.107 -28.888 -2.142 1.00 15.62 ? 173 THR B O 1 ATOM 3280 C CB . THR B 1 153 ? 63.104 -31.498 -3.357 1.00 15.86 ? 173 THR B CB 1 ATOM 3281 O OG1 . THR B 1 153 ? 63.087 -32.919 -3.109 1.00 17.25 ? 173 THR B OG1 1 ATOM 3282 C CG2 . THR B 1 153 ? 64.099 -30.810 -2.414 1.00 16.73 ? 173 THR B CG2 1 ATOM 3283 N N . ASN B 1 154 ? 61.915 -28.805 -4.222 1.00 17.49 ? 174 ASN B N 1 ATOM 3284 C CA . ASN B 1 154 ? 62.015 -27.338 -4.187 1.00 18.59 ? 174 ASN B CA 1 ATOM 3285 C C . ASN B 1 154 ? 60.689 -26.680 -3.761 1.00 17.70 ? 174 ASN B C 1 ATOM 3286 O O . ASN B 1 154 ? 60.664 -25.847 -2.868 1.00 15.77 ? 174 ASN B O 1 ATOM 3287 C CB . ASN B 1 154 ? 62.454 -26.755 -5.502 1.00 18.24 ? 174 ASN B CB 1 ATOM 3288 C CG . ASN B 1 154 ? 63.766 -27.350 -5.980 1.00 20.92 ? 174 ASN B CG 1 ATOM 3289 O OD1 . ASN B 1 154 ? 63.822 -28.525 -6.339 1.00 22.52 ? 174 ASN B OD1 1 ATOM 3290 N ND2 . ASN B 1 154 ? 64.813 -26.557 -5.992 1.00 19.54 ? 174 ASN B ND2 1 ATOM 3291 N N . MET B 1 155 ? 59.594 -27.113 -4.394 1.00 16.37 ? 175 MET B N 1 ATOM 3292 C CA . MET B 1 155 ? 58.311 -26.458 -4.143 1.00 15.42 ? 175 MET B CA 1 ATOM 3293 C C . MET B 1 155 ? 57.762 -26.804 -2.794 1.00 14.03 ? 175 MET B C 1 ATOM 3294 O O . MET B 1 155 ? 57.363 -25.893 -2.057 1.00 14.28 ? 175 MET B O 1 ATOM 3295 C CB . MET B 1 155 ? 57.300 -26.638 -5.274 1.00 14.49 ? 175 MET B CB 1 ATOM 3296 C CG . MET B 1 155 ? 57.789 -26.041 -6.583 1.00 15.16 ? 175 MET B CG 1 ATOM 3297 S SD . MET B 1 155 ? 56.495 -25.887 -7.859 1.00 15.33 ? 175 MET B SD 1 ATOM 3298 C CE . MET B 1 155 ? 56.085 -27.644 -8.025 1.00 13.86 ? 175 MET B CE 1 ATOM 3299 N N . PRO B 1 156 ? 57.689 -28.108 -2.430 1.00 15.25 ? 176 PRO B N 1 ATOM 3300 C CA . PRO B 1 156 ? 57.185 -28.398 -1.091 1.00 15.13 ? 176 PRO B CA 1 ATOM 3301 C C . PRO B 1 156 ? 57.995 -27.756 0.044 1.00 15.89 ? 176 PRO B C 1 ATOM 3302 O O . PRO B 1 156 ? 57.391 -27.306 1.003 1.00 15.16 ? 176 PRO B O 1 ATOM 3303 C CB . PRO B 1 156 ? 57.244 -29.939 -1.005 1.00 16.38 ? 176 PRO B CB 1 ATOM 3304 C CG . PRO B 1 156 ? 57.142 -30.379 -2.443 1.00 16.38 ? 176 PRO B CG 1 ATOM 3305 C CD . PRO B 1 156 ? 57.866 -29.338 -3.209 1.00 16.18 ? 176 PRO B CD 1 ATOM 3306 N N . GLU B 1 157 ? 59.326 -27.725 -0.080 1.00 15.73 ? 177 GLU B N 1 ATOM 3307 C CA . GLU B 1 157 ? 60.182 -27.080 0.926 1.00 17.57 ? 177 GLU B CA 1 ATOM 3308 C C . GLU B 1 157 ? 59.907 -25.552 1.008 1.00 18.74 ? 177 GLU B C 1 ATOM 3309 O O . GLU B 1 157 ? 59.790 -24.981 2.092 1.00 18.29 ? 177 GLU B O 1 ATOM 3310 C CB . GLU B 1 157 ? 61.660 -27.337 0.659 1.00 16.89 ? 177 GLU B CB 1 ATOM 3311 C CG . GLU B 1 157 ? 62.051 -28.749 0.998 1.00 18.21 ? 177 GLU B CG 1 ATOM 3312 C CD . GLU B 1 157 ? 63.538 -29.049 0.845 1.00 18.31 ? 177 GLU B CD 1 ATOM 3313 O OE1 . GLU B 1 157 ? 63.891 -30.214 1.053 1.00 20.00 ? 177 GLU B OE1 1 ATOM 3314 O OE2 . GLU B 1 157 ? 64.351 -28.166 0.550 1.00 18.42 ? 177 GLU B OE2 1 ATOM 3315 N N . GLU B 1 158 ? 59.757 -24.926 -0.150 1.00 19.31 ? 178 GLU B N 1 ATOM 3316 C CA . GLU B 1 158 ? 59.401 -23.501 -0.195 1.00 19.49 ? 178 GLU B CA 1 ATOM 3317 C C . GLU B 1 158 ? 58.069 -23.273 0.507 1.00 19.39 ? 178 GLU B C 1 ATOM 3318 O O . GLU B 1 158 ? 57.962 -22.401 1.360 1.00 18.46 ? 178 GLU B O 1 ATOM 3319 C CB . GLU B 1 158 ? 59.371 -22.956 -1.613 1.00 21.54 ? 178 GLU B CB 1 ATOM 3320 C CG . GLU B 1 158 ? 59.010 -21.459 -1.616 1.00 23.40 ? 178 GLU B CG 1 ATOM 3321 C CD . GLU B 1 158 ? 59.103 -20.775 -2.953 1.00 24.58 ? 178 GLU B CD 1 ATOM 3322 O OE1 . GLU B 1 158 ? 58.615 -19.633 -3.015 1.00 21.73 ? 178 GLU B OE1 1 ATOM 3323 O OE2 . GLU B 1 158 ? 59.640 -21.331 -3.923 1.00 24.29 ? 178 GLU B OE2 1 ATOM 3324 N N . ALA B 1 159 ? 57.080 -24.099 0.199 1.00 18.29 ? 179 ALA B N 1 ATOM 3325 C CA . ALA B 1 159 ? 55.760 -23.991 0.798 1.00 18.11 ? 179 ALA B CA 1 ATOM 3326 C C . ALA B 1 159 ? 55.756 -24.230 2.316 1.00 18.75 ? 179 ALA B C 1 ATOM 3327 O O . ALA B 1 159 ? 55.075 -23.544 3.058 1.00 18.75 ? 179 ALA B O 1 ATOM 3328 C CB . ALA B 1 159 ? 54.790 -24.954 0.160 1.00 16.88 ? 179 ALA B CB 1 ATOM 3329 N N . ALA B 1 160 ? 56.478 -25.257 2.743 1.00 17.42 ? 180 ALA B N 1 ATOM 3330 C CA . ALA B 1 160 ? 56.546 -25.594 4.172 1.00 17.07 ? 180 ALA B CA 1 ATOM 3331 C C . ALA B 1 160 ? 57.450 -24.642 4.973 1.00 17.61 ? 180 ALA B C 1 ATOM 3332 O O . ALA B 1 160 ? 57.320 -24.544 6.184 1.00 18.57 ? 180 ALA B O 1 ATOM 3333 C CB . ALA B 1 160 ? 57.019 -27.032 4.359 1.00 16.53 ? 180 ALA B CB 1 ATOM 3334 N N . GLY B 1 161 ? 58.336 -23.943 4.279 1.00 19.17 ? 181 GLY B N 1 ATOM 3335 C CA . GLY B 1 161 ? 59.309 -23.029 4.902 1.00 21.65 ? 181 GLY B CA 1 ATOM 3336 C C . GLY B 1 161 ? 60.507 -23.730 5.513 1.00 22.42 ? 181 GLY B C 1 ATOM 3337 O O . GLY B 1 161 ? 61.046 -23.287 6.487 1.00 22.84 ? 181 GLY B O 1 ATOM 3338 N N . GLY B 1 162 ? 60.936 -24.832 4.919 1.00 22.16 ? 182 GLY B N 1 ATOM 3339 C CA . GLY B 1 162 ? 62.062 -25.586 5.413 1.00 21.39 ? 182 GLY B CA 1 ATOM 3340 C C . GLY B 1 162 ? 62.043 -27.034 4.933 1.00 22.01 ? 182 GLY B C 1 ATOM 3341 O O . GLY B 1 162 ? 61.213 -27.421 4.080 1.00 18.37 ? 182 GLY B O 1 ATOM 3342 N N . TYR B 1 163 ? 62.883 -27.837 5.560 1.00 20.42 ? 183 TYR B N 1 ATOM 3343 C CA . TYR B 1 163 ? 63.094 -29.223 5.140 1.00 24.32 ? 183 TYR B CA 1 ATOM 3344 C C . TYR B 1 163 ? 63.235 -30.239 6.252 1.00 21.48 ? 183 TYR B C 1 ATOM 3345 O O . TYR B 1 163 ? 63.251 -31.410 5.986 1.00 21.84 ? 183 TYR B O 1 ATOM 3346 C CB . TYR B 1 163 ? 64.313 -29.309 4.175 1.00 27.96 ? 183 TYR B CB 1 ATOM 3347 C CG . TYR B 1 163 ? 65.595 -28.885 4.828 1.00 33.85 ? 183 TYR B CG 1 ATOM 3348 C CD1 . TYR B 1 163 ? 65.976 -27.565 4.809 1.00 41.05 ? 183 TYR B CD1 1 ATOM 3349 C CD2 . TYR B 1 163 ? 66.389 -29.797 5.516 1.00 42.21 ? 183 TYR B CD2 1 ATOM 3350 C CE1 . TYR B 1 163 ? 67.114 -27.138 5.459 1.00 49.22 ? 183 TYR B CE1 1 ATOM 3351 C CE2 . TYR B 1 163 ? 67.546 -29.396 6.179 1.00 48.99 ? 183 TYR B CE2 1 ATOM 3352 C CZ . TYR B 1 163 ? 67.899 -28.057 6.152 1.00 53.28 ? 183 TYR B CZ 1 ATOM 3353 O OH . TYR B 1 163 ? 69.029 -27.611 6.808 1.00 65.29 ? 183 TYR B OH 1 ATOM 3354 N N . SER B 1 164 ? 63.289 -29.798 7.494 1.00 21.72 ? 184 SER B N 1 ATOM 3355 C CA . SER B 1 164 ? 63.589 -30.683 8.623 1.00 22.07 ? 184 SER B CA 1 ATOM 3356 C C . SER B 1 164 ? 62.360 -31.506 8.998 1.00 20.88 ? 184 SER B C 1 ATOM 3357 O O . SER B 1 164 ? 61.242 -31.178 8.620 1.00 19.84 ? 184 SER B O 1 ATOM 3358 C CB . SER B 1 164 ? 64.016 -29.819 9.852 1.00 21.57 ? 184 SER B CB 1 ATOM 3359 O OG . SER B 1 164 ? 62.913 -29.018 10.309 1.00 22.61 ? 184 SER B OG 1 ATOM 3360 N N . LEU B 1 165 ? 62.562 -32.456 9.888 1.00 19.48 ? 185 LEU B N 1 ATOM 3361 C CA . LEU B 1 165 ? 61.477 -33.226 10.443 1.00 20.10 ? 185 LEU B CA 1 ATOM 3362 C C . LEU B 1 165 ? 60.427 -32.340 11.185 1.00 19.56 ? 185 LEU B C 1 ATOM 3363 O O . LEU B 1 165 ? 59.202 -32.582 11.121 1.00 17.10 ? 185 LEU B O 1 ATOM 3364 C CB . LEU B 1 165 ? 62.046 -34.309 11.393 1.00 19.07 ? 185 LEU B CB 1 ATOM 3365 C CG . LEU B 1 165 ? 61.067 -35.307 11.953 1.00 19.33 ? 185 LEU B CG 1 ATOM 3366 C CD1 . LEU B 1 165 ? 60.552 -36.243 10.830 1.00 20.97 ? 185 LEU B CD1 1 ATOM 3367 C CD2 . LEU B 1 165 ? 61.700 -36.082 13.107 1.00 20.00 ? 185 LEU B CD2 1 ATOM 3368 N N . SER B 1 166 ? 60.918 -31.352 11.913 1.00 18.63 ? 186 SER B N 1 ATOM 3369 C CA . SER B 1 166 ? 60.022 -30.532 12.727 1.00 20.01 ? 186 SER B CA 1 ATOM 3370 C C . SER B 1 166 ? 59.183 -29.574 11.830 1.00 19.11 ? 186 SER B C 1 ATOM 3371 O O . SER B 1 166 ? 58.027 -29.323 12.126 1.00 19.54 ? 186 SER B O 1 ATOM 3372 C CB . SER B 1 166 ? 60.795 -29.795 13.848 1.00 19.55 ? 186 SER B CB 1 ATOM 3373 O OG . SER B 1 166 ? 61.685 -28.895 13.275 1.00 23.00 ? 186 SER B OG 1 ATOM 3374 N N . VAL B 1 167 ? 59.778 -29.064 10.764 1.00 18.13 ? 187 VAL B N 1 ATOM 3375 C CA . VAL B 1 167 ? 59.034 -28.309 9.755 1.00 19.03 ? 187 VAL B CA 1 ATOM 3376 C C . VAL B 1 167 ? 57.958 -29.219 9.111 1.00 18.45 ? 187 VAL B C 1 ATOM 3377 O O . VAL B 1 167 ? 56.808 -28.798 8.939 1.00 17.44 ? 187 VAL B O 1 ATOM 3378 C CB . VAL B 1 167 ? 59.964 -27.684 8.705 1.00 19.22 ? 187 VAL B CB 1 ATOM 3379 C CG1 . VAL B 1 167 ? 59.174 -27.136 7.506 1.00 18.84 ? 187 VAL B CG1 1 ATOM 3380 C CG2 . VAL B 1 167 ? 60.794 -26.570 9.370 1.00 19.53 ? 187 VAL B CG2 1 ATOM 3381 N N . ALA B 1 168 ? 58.330 -30.464 8.824 1.00 16.61 ? 188 ALA B N 1 ATOM 3382 C CA . ALA B 1 168 ? 57.352 -31.472 8.302 1.00 16.29 ? 188 ALA B CA 1 ATOM 3383 C C . ALA B 1 168 ? 56.162 -31.663 9.240 1.00 16.20 ? 188 ALA B C 1 ATOM 3384 O O . ALA B 1 168 ? 55.007 -31.770 8.798 1.00 14.97 ? 188 ALA B O 1 ATOM 3385 C CB . ALA B 1 168 ? 58.020 -32.817 8.060 1.00 16.68 ? 188 ALA B CB 1 ATOM 3386 N N . LYS B 1 169 ? 56.440 -31.743 10.538 1.00 14.90 ? 189 LYS B N 1 ATOM 3387 C CA . LYS B 1 169 ? 55.399 -31.945 11.472 1.00 15.77 ? 189 LYS B CA 1 ATOM 3388 C C . LYS B 1 169 ? 54.440 -30.727 11.445 1.00 14.50 ? 189 LYS B C 1 ATOM 3389 O O . LYS B 1 169 ? 53.201 -30.901 11.523 1.00 13.75 ? 189 LYS B O 1 ATOM 3390 C CB . LYS B 1 169 ? 55.962 -32.194 12.902 1.00 18.87 ? 189 LYS B CB 1 ATOM 3391 C CG . LYS B 1 169 ? 54.894 -32.202 14.004 1.00 20.25 ? 189 LYS B CG 1 ATOM 3392 C CD . LYS B 1 169 ? 53.788 -33.220 13.768 1.00 22.66 ? 189 LYS B CD 1 ATOM 3393 C CE . LYS B 1 169 ? 52.914 -33.301 15.017 1.00 26.01 ? 189 LYS B CE 1 ATOM 3394 N NZ . LYS B 1 169 ? 51.597 -33.965 14.857 1.00 30.80 ? 189 LYS B NZ 1 ATOM 3395 N N . THR B 1 170 ? 54.997 -29.531 11.406 1.00 14.59 ? 190 THR B N 1 ATOM 3396 C CA . THR B 1 170 ? 54.099 -28.332 11.368 1.00 17.10 ? 190 THR B CA 1 ATOM 3397 C C . THR B 1 170 ? 53.253 -28.272 10.051 1.00 16.38 ? 190 THR B C 1 ATOM 3398 O O . THR B 1 170 ? 52.110 -27.834 10.035 1.00 15.11 ? 190 THR B O 1 ATOM 3399 C CB . THR B 1 170 ? 54.830 -26.992 11.525 1.00 16.35 ? 190 THR B CB 1 ATOM 3400 O OG1 . THR B 1 170 ? 55.705 -26.754 10.411 1.00 16.32 ? 190 THR B OG1 1 ATOM 3401 C CG2 . THR B 1 170 ? 55.575 -26.941 12.847 1.00 18.13 ? 190 THR B CG2 1 ATOM 3402 N N . TYR B 1 171 ? 53.876 -28.672 8.957 1.00 15.35 ? 191 TYR B N 1 ATOM 3403 C CA . TYR B 1 171 ? 53.184 -28.724 7.672 1.00 15.96 ? 191 TYR B CA 1 ATOM 3404 C C . TYR B 1 171 ? 52.079 -29.776 7.721 1.00 14.68 ? 191 TYR B C 1 ATOM 3405 O O . TYR B 1 171 ? 50.963 -29.533 7.279 1.00 16.83 ? 191 TYR B O 1 ATOM 3406 C CB . TYR B 1 171 ? 54.179 -29.021 6.583 1.00 16.06 ? 191 TYR B CB 1 ATOM 3407 C CG . TYR B 1 171 ? 53.805 -28.678 5.158 1.00 17.21 ? 191 TYR B CG 1 ATOM 3408 C CD1 . TYR B 1 171 ? 53.207 -27.473 4.839 1.00 18.19 ? 191 TYR B CD1 1 ATOM 3409 C CD2 . TYR B 1 171 ? 54.256 -29.473 4.102 1.00 16.84 ? 191 TYR B CD2 1 ATOM 3410 C CE1 . TYR B 1 171 ? 52.952 -27.130 3.521 1.00 18.22 ? 191 TYR B CE1 1 ATOM 3411 C CE2 . TYR B 1 171 ? 53.998 -29.143 2.782 1.00 16.68 ? 191 TYR B CE2 1 ATOM 3412 C CZ . TYR B 1 171 ? 53.363 -27.963 2.497 1.00 17.05 ? 191 TYR B CZ 1 ATOM 3413 O OH . TYR B 1 171 ? 53.138 -27.556 1.209 1.00 17.17 ? 191 TYR B OH 1 ATOM 3414 N N . ALA B 1 172 ? 52.385 -30.913 8.310 1.00 14.58 ? 192 ALA B N 1 ATOM 3415 C CA . ALA B 1 172 ? 51.408 -31.963 8.476 1.00 14.80 ? 192 ALA B CA 1 ATOM 3416 C C . ALA B 1 172 ? 50.181 -31.459 9.255 1.00 16.66 ? 192 ALA B C 1 ATOM 3417 O O . ALA B 1 172 ? 49.046 -31.748 8.908 1.00 17.29 ? 192 ALA B O 1 ATOM 3418 C CB . ALA B 1 172 ? 52.011 -33.142 9.155 1.00 14.00 ? 192 ALA B CB 1 ATOM 3419 N N . ASP B 1 173 ? 50.444 -30.758 10.351 1.00 17.55 ? 193 ASP B N 1 ATOM 3420 C CA . ASP B 1 173 ? 49.357 -30.289 11.212 1.00 17.48 ? 193 ASP B CA 1 ATOM 3421 C C . ASP B 1 173 ? 48.462 -29.279 10.499 1.00 16.87 ? 193 ASP B C 1 ATOM 3422 O O . ASP B 1 173 ? 47.250 -29.286 10.698 1.00 17.36 ? 193 ASP B O 1 ATOM 3423 C CB . ASP B 1 173 ? 49.939 -29.710 12.509 1.00 17.92 ? 193 ASP B CB 1 ATOM 3424 C CG . ASP B 1 173 ? 50.420 -30.795 13.448 1.00 20.02 ? 193 ASP B CG 1 ATOM 3425 O OD1 . ASP B 1 173 ? 50.032 -31.986 13.327 1.00 20.02 ? 193 ASP B OD1 1 ATOM 3426 O OD2 . ASP B 1 173 ? 51.187 -30.474 14.353 1.00 21.91 ? 193 ASP B OD2 1 ATOM 3427 N N . LEU B 1 174 ? 49.057 -28.414 9.687 1.00 16.30 ? 194 LEU B N 1 ATOM 3428 C CA . LEU B 1 174 ? 48.289 -27.518 8.853 1.00 16.82 ? 194 LEU B CA 1 ATOM 3429 C C . LEU B 1 174 ? 47.312 -28.290 7.969 1.00 17.77 ? 194 LEU B C 1 ATOM 3430 O O . LEU B 1 174 ? 46.108 -28.027 7.938 1.00 16.25 ? 194 LEU B O 1 ATOM 3431 C CB . LEU B 1 174 ? 49.232 -26.732 7.984 1.00 17.36 ? 194 LEU B CB 1 ATOM 3432 C CG . LEU B 1 174 ? 48.571 -25.782 6.987 1.00 19.15 ? 194 LEU B CG 1 ATOM 3433 C CD1 . LEU B 1 174 ? 48.006 -24.576 7.735 1.00 20.88 ? 194 LEU B CD1 1 ATOM 3434 C CD2 . LEU B 1 174 ? 49.544 -25.317 5.927 1.00 19.41 ? 194 LEU B CD2 1 ATOM 3435 N N . LEU B 1 175 ? 47.853 -29.277 7.266 1.00 18.06 ? 195 LEU B N 1 ATOM 3436 C CA . LEU B 1 175 ? 47.067 -30.075 6.294 1.00 17.22 ? 195 LEU B CA 1 ATOM 3437 C C . LEU B 1 175 ? 46.039 -30.920 6.979 1.00 17.45 ? 195 LEU B C 1 ATOM 3438 O O . LEU B 1 175 ? 44.930 -31.083 6.478 1.00 18.16 ? 195 LEU B O 1 ATOM 3439 C CB . LEU B 1 175 ? 47.996 -30.875 5.372 1.00 16.29 ? 195 LEU B CB 1 ATOM 3440 C CG . LEU B 1 175 ? 48.967 -29.989 4.558 1.00 16.69 ? 195 LEU B CG 1 ATOM 3441 C CD1 . LEU B 1 175 ? 49.917 -30.848 3.683 1.00 17.18 ? 195 LEU B CD1 1 ATOM 3442 C CD2 . LEU B 1 175 ? 48.287 -28.924 3.693 1.00 16.38 ? 195 LEU B CD2 1 ATOM 3443 N N . THR B 1 176 ? 46.393 -31.441 8.141 1.00 17.37 ? 196 THR B N 1 ATOM 3444 C CA . THR B 1 176 ? 45.494 -32.264 8.926 1.00 16.61 ? 196 THR B CA 1 ATOM 3445 C C . THR B 1 176 ? 44.236 -31.463 9.413 1.00 17.98 ? 196 THR B C 1 ATOM 3446 O O . THR B 1 176 ? 43.123 -31.960 9.350 1.00 17.14 ? 196 THR B O 1 ATOM 3447 C CB . THR B 1 176 ? 46.240 -32.845 10.113 1.00 17.19 ? 196 THR B CB 1 ATOM 3448 O OG1 . THR B 1 176 ? 47.080 -33.903 9.651 1.00 17.60 ? 196 THR B OG1 1 ATOM 3449 C CG2 . THR B 1 176 ? 45.280 -33.419 11.173 1.00 17.62 ? 196 THR B CG2 1 ATOM 3450 N N . GLU B 1 177 ? 44.439 -30.206 9.798 1.00 18.98 ? 197 GLU B N 1 ATOM 3451 C CA . GLU B 1 177 ? 43.348 -29.315 10.136 1.00 20.94 ? 197 GLU B CA 1 ATOM 3452 C C . GLU B 1 177 ? 42.463 -29.018 8.898 1.00 19.36 ? 197 GLU B C 1 ATOM 3453 O O . GLU B 1 177 ? 41.238 -28.885 9.002 1.00 21.20 ? 197 GLU B O 1 ATOM 3454 C CB . GLU B 1 177 ? 43.880 -28.021 10.766 1.00 23.70 ? 197 GLU B CB 1 ATOM 3455 C CG . GLU B 1 177 ? 42.800 -27.215 11.495 1.00 27.61 ? 197 GLU B CG 1 ATOM 3456 C CD . GLU B 1 177 ? 42.263 -28.007 12.707 1.00 32.29 ? 197 GLU B CD 1 ATOM 3457 O OE1 . GLU B 1 177 ? 43.000 -28.201 13.703 1.00 39.75 ? 197 GLU B OE1 1 ATOM 3458 O OE2 . GLU B 1 177 ? 41.131 -28.472 12.669 1.00 34.16 ? 197 GLU B OE2 1 ATOM 3459 N N . ARG B 1 178 ? 43.069 -28.867 7.747 1.00 18.34 ? 198 ARG B N 1 ATOM 3460 C CA . ARG B 1 178 ? 42.294 -28.658 6.498 1.00 18.63 ? 198 ARG B CA 1 ATOM 3461 C C . ARG B 1 178 ? 41.367 -29.829 6.243 1.00 17.66 ? 198 ARG B C 1 ATOM 3462 O O . ARG B 1 178 ? 40.235 -29.609 5.828 1.00 20.05 ? 198 ARG B O 1 ATOM 3463 C CB . ARG B 1 178 ? 43.190 -28.414 5.311 1.00 19.43 ? 198 ARG B CB 1 ATOM 3464 C CG . ARG B 1 178 ? 43.857 -27.074 5.332 1.00 19.34 ? 198 ARG B CG 1 ATOM 3465 C CD . ARG B 1 178 ? 44.641 -26.889 4.071 1.00 19.80 ? 198 ARG B CD 1 ATOM 3466 N NE . ARG B 1 178 ? 45.400 -25.644 4.072 1.00 19.63 ? 198 ARG B NE 1 ATOM 3467 C CZ . ARG B 1 178 ? 46.371 -25.349 3.224 1.00 21.17 ? 198 ARG B CZ 1 ATOM 3468 N NH1 . ARG B 1 178 ? 46.762 -26.219 2.288 1.00 21.16 ? 198 ARG B NH1 1 ATOM 3469 N NH2 . ARG B 1 178 ? 46.987 -24.175 3.330 1.00 23.96 ? 198 ARG B NH2 1 ATOM 3470 N N . ILE B 1 179 ? 41.820 -31.038 6.573 1.00 15.50 ? 199 ILE B N 1 ATOM 3471 C CA . ILE B 1 179 ? 41.003 -32.220 6.439 1.00 15.38 ? 199 ILE B CA 1 ATOM 3472 C C . ILE B 1 179 ? 39.871 -32.229 7.491 1.00 19.59 ? 199 ILE B C 1 ATOM 3473 O O . ILE B 1 179 ? 38.723 -32.545 7.181 1.00 19.08 ? 199 ILE B O 1 ATOM 3474 C CB . ILE B 1 179 ? 41.841 -33.493 6.566 1.00 14.52 ? 199 ILE B CB 1 ATOM 3475 C CG1 . ILE B 1 179 ? 42.836 -33.634 5.414 1.00 15.63 ? 199 ILE B CG1 1 ATOM 3476 C CG2 . ILE B 1 179 ? 40.986 -34.737 6.627 1.00 15.35 ? 199 ILE B CG2 1 ATOM 3477 C CD1 . ILE B 1 179 ? 43.893 -34.703 5.711 1.00 14.73 ? 199 ILE B CD1 1 ATOM 3478 N N . LYS B 1 180 ? 40.218 -31.993 8.753 1.00 20.02 ? 200 LYS B N 1 ATOM 3479 C CA . LYS B 1 180 ? 39.212 -32.121 9.809 1.00 25.09 ? 200 LYS B CA 1 ATOM 3480 C C . LYS B 1 180 ? 38.117 -31.026 9.738 1.00 24.78 ? 200 LYS B C 1 ATOM 3481 O O . LYS B 1 180 ? 36.955 -31.336 9.831 1.00 23.82 ? 200 LYS B O 1 ATOM 3482 C CB . LYS B 1 180 ? 39.868 -32.129 11.186 1.00 27.24 ? 200 LYS B CB 1 ATOM 3483 C CG . LYS B 1 180 ? 40.722 -33.379 11.329 1.00 29.73 ? 200 LYS B CG 1 ATOM 3484 C CD . LYS B 1 180 ? 41.180 -33.675 12.741 1.00 35.14 ? 200 LYS B CD 1 ATOM 3485 C CE . LYS B 1 180 ? 42.174 -32.649 13.156 1.00 41.57 ? 200 LYS B CE 1 ATOM 3486 N NZ . LYS B 1 180 ? 42.555 -32.790 14.601 1.00 46.50 ? 200 LYS B NZ 1 ATOM 3487 N N . THR B 1 181 ? 38.500 -29.781 9.514 1.00 23.53 ? 201 THR B N 1 ATOM 3488 C CA . THR B 1 181 ? 37.539 -28.659 9.613 1.00 24.97 ? 201 THR B CA 1 ATOM 3489 C C . THR B 1 181 ? 37.644 -27.617 8.536 1.00 26.32 ? 201 THR B C 1 ATOM 3490 O O . THR B 1 181 ? 36.782 -26.740 8.470 1.00 25.94 ? 201 THR B O 1 ATOM 3491 C CB . THR B 1 181 ? 37.748 -27.873 10.972 1.00 24.66 ? 201 THR B CB 1 ATOM 3492 O OG1 . THR B 1 181 ? 39.069 -27.298 11.026 1.00 24.97 ? 201 THR B OG1 1 ATOM 3493 C CG2 . THR B 1 181 ? 37.579 -28.760 12.152 1.00 24.93 ? 201 THR B CG2 1 ATOM 3494 N N . GLY B 1 182 ? 38.692 -27.665 7.715 1.00 21.39 ? 202 GLY B N 1 ATOM 3495 C CA . GLY B 1 182 ? 38.948 -26.589 6.779 1.00 21.11 ? 202 GLY B CA 1 ATOM 3496 C C . GLY B 1 182 ? 38.588 -26.936 5.339 1.00 21.28 ? 202 GLY B C 1 ATOM 3497 O O . GLY B 1 182 ? 37.655 -27.672 5.080 1.00 19.53 ? 202 GLY B O 1 ATOM 3498 N N . THR B 1 183 ? 39.377 -26.434 4.415 1.00 21.46 ? 203 THR B N 1 ATOM 3499 C CA . THR B 1 183 ? 39.065 -26.545 2.987 1.00 23.55 ? 203 THR B CA 1 ATOM 3500 C C . THR B 1 183 ? 38.973 -27.957 2.381 1.00 23.09 ? 203 THR B C 1 ATOM 3501 O O . THR B 1 183 ? 38.377 -28.098 1.325 1.00 26.54 ? 203 THR B O 1 ATOM 3502 C CB . THR B 1 183 ? 40.042 -25.694 2.147 1.00 26.67 ? 203 THR B CB 1 ATOM 3503 O OG1 . THR B 1 183 ? 41.411 -25.975 2.547 1.00 27.75 ? 203 THR B OG1 1 ATOM 3504 C CG2 . THR B 1 183 ? 39.737 -24.195 2.384 1.00 26.19 ? 203 THR B CG2 1 ATOM 3505 N N . TYR B 1 184 ? 39.521 -28.975 3.026 1.00 18.51 ? 204 TYR B N 1 ATOM 3506 C CA . TYR B 1 184 ? 39.364 -30.349 2.544 1.00 18.44 ? 204 TYR B CA 1 ATOM 3507 C C . TYR B 1 184 ? 38.261 -31.131 3.203 1.00 19.21 ? 204 TYR B C 1 ATOM 3508 O O . TYR B 1 184 ? 38.022 -32.282 2.809 1.00 18.13 ? 204 TYR B O 1 ATOM 3509 C CB . TYR B 1 184 ? 40.712 -31.179 2.666 1.00 17.02 ? 204 TYR B CB 1 ATOM 3510 C CG . TYR B 1 184 ? 41.952 -30.469 2.132 1.00 15.88 ? 204 TYR B CG 1 ATOM 3511 C CD1 . TYR B 1 184 ? 41.888 -29.600 1.040 1.00 16.13 ? 204 TYR B CD1 1 ATOM 3512 C CD2 . TYR B 1 184 ? 43.197 -30.638 2.755 1.00 15.17 ? 204 TYR B CD2 1 ATOM 3513 C CE1 . TYR B 1 184 ? 43.024 -28.915 0.608 1.00 16.26 ? 204 TYR B CE1 1 ATOM 3514 C CE2 . TYR B 1 184 ? 44.332 -30.026 2.279 1.00 15.15 ? 204 TYR B CE2 1 ATOM 3515 C CZ . TYR B 1 184 ? 44.272 -29.154 1.209 1.00 15.81 ? 204 TYR B CZ 1 ATOM 3516 O OH . TYR B 1 184 ? 45.421 -28.483 0.768 1.00 15.38 ? 204 TYR B OH 1 ATOM 3517 N N . SER B 1 185 ? 37.588 -30.563 4.218 1.00 21.13 ? 205 SER B N 1 ATOM 3518 C CA . SER B 1 185 ? 36.671 -31.388 5.031 1.00 23.89 ? 205 SER B CA 1 ATOM 3519 C C . SER B 1 185 ? 35.469 -31.927 4.264 1.00 24.18 ? 205 SER B C 1 ATOM 3520 O O . SER B 1 185 ? 35.041 -33.024 4.545 1.00 24.21 ? 205 SER B O 1 ATOM 3521 C CB . SER B 1 185 ? 36.183 -30.704 6.319 1.00 26.94 ? 205 SER B CB 1 ATOM 3522 O OG . SER B 1 185 ? 35.835 -29.352 6.043 1.00 29.72 ? 205 SER B OG 1 ATOM 3523 N N . SER B 1 186 ? 34.961 -31.192 3.294 1.00 25.45 ? 206 SER B N 1 ATOM 3524 C CA . SER B 1 186 ? 33.862 -31.765 2.475 1.00 30.10 ? 206 SER B CA 1 ATOM 3525 C C . SER B 1 186 ? 34.387 -32.789 1.425 1.00 29.44 ? 206 SER B C 1 ATOM 3526 O O . SER B 1 186 ? 33.691 -33.694 1.034 1.00 31.50 ? 206 SER B O 1 ATOM 3527 C CB . SER B 1 186 ? 33.022 -30.668 1.833 1.00 28.59 ? 206 SER B CB 1 ATOM 3528 O OG . SER B 1 186 ? 33.776 -30.048 0.821 1.00 33.77 ? 206 SER B OG 1 ATOM 3529 N N . LYS B 1 187 ? 35.628 -32.666 1.000 1.00 30.57 ? 207 LYS B N 1 ATOM 3530 C CA . LYS B 1 187 ? 36.182 -33.651 0.019 1.00 31.77 ? 207 LYS B CA 1 ATOM 3531 C C . LYS B 1 187 ? 36.580 -34.993 0.629 1.00 30.55 ? 207 LYS B C 1 ATOM 3532 O O . LYS B 1 187 ? 36.561 -36.023 -0.067 1.00 25.83 ? 207 LYS B O 1 ATOM 3533 C CB . LYS B 1 187 ? 37.376 -33.058 -0.696 1.00 35.11 ? 207 LYS B CB 1 ATOM 3534 C CG . LYS B 1 187 ? 37.068 -31.730 -1.353 1.00 40.94 ? 207 LYS B CG 1 ATOM 3535 C CD . LYS B 1 187 ? 38.348 -30.953 -1.616 1.00 47.17 ? 207 LYS B CD 1 ATOM 3536 C CE . LYS B 1 187 ? 38.096 -29.934 -2.707 1.00 50.97 ? 207 LYS B CE 1 ATOM 3537 N NZ . LYS B 1 187 ? 39.372 -29.271 -3.076 1.00 53.68 ? 207 LYS B NZ 1 ATOM 3538 N N . LYS B 1 188 ? 37.003 -34.981 1.900 1.00 26.70 ? 208 LYS B N 1 ATOM 3539 C CA . LYS B 1 188 ? 37.692 -36.150 2.473 1.00 26.59 ? 208 LYS B CA 1 ATOM 3540 C C . LYS B 1 188 ? 36.901 -37.430 2.533 1.00 24.44 ? 208 LYS B C 1 ATOM 3541 O O . LYS B 1 188 ? 37.479 -38.516 2.433 1.00 23.27 ? 208 LYS B O 1 ATOM 3542 C CB . LYS B 1 188 ? 38.267 -35.854 3.886 1.00 30.77 ? 208 LYS B CB 1 ATOM 3543 C CG . LYS B 1 188 ? 37.251 -35.375 4.883 1.00 31.05 ? 208 LYS B CG 1 ATOM 3544 C CD . LYS B 1 188 ? 37.248 -36.134 6.177 1.00 32.12 ? 208 LYS B CD 1 ATOM 3545 C CE . LYS B 1 188 ? 36.099 -35.648 7.059 1.00 33.90 ? 208 LYS B CE 1 ATOM 3546 N NZ . LYS B 1 188 ? 36.352 -34.306 7.642 1.00 38.61 ? 208 LYS B NZ 1 ATOM 3547 N N . ASP B 1 189 ? 35.589 -37.357 2.607 1.00 27.82 ? 209 ASP B N 1 ATOM 3548 C CA A ASP B 1 189 ? 34.817 -38.616 2.629 0.50 30.49 ? 209 ASP B CA 1 ATOM 3549 C CA B ASP B 1 189 ? 34.717 -38.578 2.576 0.50 32.04 ? 209 ASP B CA 1 ATOM 3550 C C . ASP B 1 189 ? 34.906 -39.359 1.271 1.00 29.42 ? 209 ASP B C 1 ATOM 3551 O O . ASP B 1 189 ? 34.906 -40.605 1.226 1.00 35.48 ? 209 ASP B O 1 ATOM 3552 C CB A ASP B 1 189 ? 33.431 -38.412 3.249 0.50 33.67 ? 209 ASP B CB 1 ATOM 3553 C CB B ASP B 1 189 ? 33.218 -38.241 2.703 0.50 37.33 ? 209 ASP B CB 1 ATOM 3554 C CG A ASP B 1 189 ? 33.538 -38.235 4.776 0.50 34.62 ? 209 ASP B CG 1 ATOM 3555 C CG B ASP B 1 189 ? 32.945 -36.965 3.506 0.50 41.06 ? 209 ASP B CG 1 ATOM 3556 O OD1 A ASP B 1 189 ? 33.672 -39.255 5.485 0.50 36.01 ? 209 ASP B OD1 1 ATOM 3557 O OD1 B ASP B 1 189 ? 33.441 -35.887 3.091 0.50 42.14 ? 209 ASP B OD1 1 ATOM 3558 O OD2 A ASP B 1 189 ? 33.594 -37.075 5.259 0.50 33.07 ? 209 ASP B OD2 1 ATOM 3559 O OD2 B ASP B 1 189 ? 32.221 -37.049 4.525 0.50 45.51 ? 209 ASP B OD2 1 ATOM 3560 N N . SER B 1 190 ? 35.124 -38.621 0.188 1.00 22.81 ? 210 SER B N 1 ATOM 3561 C CA . SER B 1 190 ? 35.345 -39.268 -1.100 1.00 22.02 ? 210 SER B CA 1 ATOM 3562 C C . SER B 1 190 ? 36.786 -39.858 -1.257 1.00 21.17 ? 210 SER B C 1 ATOM 3563 O O . SER B 1 190 ? 37.016 -40.674 -2.150 1.00 18.84 ? 210 SER B O 1 ATOM 3564 C CB . SER B 1 190 ? 35.043 -38.316 -2.247 1.00 19.71 ? 210 SER B CB 1 ATOM 3565 O OG . SER B 1 190 ? 36.087 -37.334 -2.392 1.00 21.78 ? 210 SER B OG 1 ATOM 3566 N N . TRP B 1 191 ? 37.714 -39.493 -0.345 1.00 17.75 ? 211 TRP B N 1 ATOM 3567 C CA . TRP B 1 191 ? 39.135 -39.877 -0.464 1.00 16.76 ? 211 TRP B CA 1 ATOM 3568 C C . TRP B 1 191 ? 39.429 -41.342 -0.201 1.00 15.43 ? 211 TRP B C 1 ATOM 3569 O O . TRP B 1 191 ? 40.438 -41.857 -0.664 1.00 15.29 ? 211 TRP B O 1 ATOM 3570 C CB . TRP B 1 191 ? 40.019 -38.975 0.434 1.00 16.63 ? 211 TRP B CB 1 ATOM 3571 C CG . TRP B 1 191 ? 40.105 -37.590 -0.031 1.00 14.84 ? 211 TRP B CG 1 ATOM 3572 C CD1 . TRP B 1 191 ? 39.523 -37.058 -1.159 1.00 15.52 ? 211 TRP B CD1 1 ATOM 3573 C CD2 . TRP B 1 191 ? 40.858 -36.535 0.571 1.00 14.64 ? 211 TRP B CD2 1 ATOM 3574 N NE1 . TRP B 1 191 ? 39.845 -35.732 -1.256 1.00 15.25 ? 211 TRP B NE1 1 ATOM 3575 C CE2 . TRP B 1 191 ? 40.650 -35.376 -0.206 1.00 14.50 ? 211 TRP B CE2 1 ATOM 3576 C CE3 . TRP B 1 191 ? 41.718 -36.467 1.693 1.00 14.08 ? 211 TRP B CE3 1 ATOM 3577 C CZ2 . TRP B 1 191 ? 41.305 -34.140 0.072 1.00 15.08 ? 211 TRP B CZ2 1 ATOM 3578 C CZ3 . TRP B 1 191 ? 42.331 -35.260 2.003 1.00 14.79 ? 211 TRP B CZ3 1 ATOM 3579 C CH2 . TRP B 1 191 ? 42.122 -34.100 1.196 1.00 15.87 ? 211 TRP B CH2 1 ATOM 3580 N N . THR B 1 192 ? 38.536 -42.025 0.493 1.00 15.55 ? 212 THR B N 1 ATOM 3581 C CA . THR B 1 192 ? 38.674 -43.435 0.747 1.00 16.98 ? 212 THR B CA 1 ATOM 3582 C C . THR B 1 192 ? 37.637 -44.304 0.046 1.00 17.48 ? 212 THR B C 1 ATOM 3583 O O . THR B 1 192 ? 37.627 -45.529 0.235 1.00 19.66 ? 212 THR B O 1 ATOM 3584 C CB . THR B 1 192 ? 38.643 -43.768 2.264 1.00 19.40 ? 212 THR B CB 1 ATOM 3585 O OG1 . THR B 1 192 ? 37.472 -43.239 2.840 1.00 20.83 ? 212 THR B OG1 1 ATOM 3586 C CG2 . THR B 1 192 ? 39.796 -43.118 2.940 1.00 20.50 ? 212 THR B CG2 1 ATOM 3587 N N . ASP B 1 193 ? 36.826 -43.718 -0.817 1.00 17.66 ? 213 ASP B N 1 ATOM 3588 C CA . ASP B 1 193 ? 35.887 -44.514 -1.611 1.00 18.16 ? 213 ASP B CA 1 ATOM 3589 C C . ASP B 1 193 ? 36.672 -45.407 -2.552 1.00 19.60 ? 213 ASP B C 1 ATOM 3590 O O . ASP B 1 193 ? 37.676 -44.976 -3.126 1.00 18.37 ? 213 ASP B O 1 ATOM 3591 C CB . ASP B 1 193 ? 34.980 -43.626 -2.459 1.00 19.65 ? 213 ASP B CB 1 ATOM 3592 C CG . ASP B 1 193 ? 33.970 -42.890 -1.629 1.00 21.59 ? 213 ASP B CG 1 ATOM 3593 O OD1 . ASP B 1 193 ? 33.785 -43.275 -0.454 1.00 25.85 ? 213 ASP B OD1 1 ATOM 3594 O OD2 . ASP B 1 193 ? 33.377 -41.931 -2.115 1.00 22.21 ? 213 ASP B OD2 1 ATOM 3595 N N . GLY B 1 194 ? 36.230 -46.655 -2.663 1.00 19.19 ? 214 GLY B N 1 ATOM 3596 C CA . GLY B 1 194 ? 36.894 -47.651 -3.496 1.00 21.09 ? 214 GLY B CA 1 ATOM 3597 C C . GLY B 1 194 ? 38.012 -48.442 -2.858 1.00 21.62 ? 214 GLY B C 1 ATOM 3598 O O . GLY B 1 194 ? 38.505 -49.382 -3.457 1.00 20.16 ? 214 GLY B O 1 ATOM 3599 N N . ILE B 1 195 ? 38.438 -48.074 -1.651 1.00 20.65 ? 215 ILE B N 1 ATOM 3600 C CA . ILE B 1 195 ? 39.521 -48.777 -1.020 1.00 22.11 ? 215 ILE B CA 1 ATOM 3601 C C . ILE B 1 195 ? 39.094 -50.209 -0.720 1.00 21.25 ? 215 ILE B C 1 ATOM 3602 O O . ILE B 1 195 ? 38.006 -50.466 -0.209 1.00 21.59 ? 215 ILE B O 1 ATOM 3603 C CB . ILE B 1 195 ? 40.013 -48.044 0.247 1.00 25.19 ? 215 ILE B CB 1 ATOM 3604 C CG1 . ILE B 1 195 ? 40.702 -46.760 -0.176 1.00 30.34 ? 215 ILE B CG1 1 ATOM 3605 C CG2 . ILE B 1 195 ? 40.990 -48.921 0.983 1.00 25.82 ? 215 ILE B CG2 1 ATOM 3606 C CD1 . ILE B 1 195 ? 41.141 -45.880 0.973 1.00 33.94 ? 215 ILE B CD1 1 ATOM 3607 N N . ASP B 1 196 ? 39.948 -51.141 -1.047 1.00 20.13 ? 216 ASP B N 1 ATOM 3608 C CA . ASP B 1 196 ? 39.652 -52.546 -0.861 1.00 21.10 ? 216 ASP B CA 1 ATOM 3609 C C . ASP B 1 196 ? 40.923 -53.280 -0.483 1.00 19.76 ? 216 ASP B C 1 ATOM 3610 O O . ASP B 1 196 ? 41.788 -53.497 -1.313 1.00 17.67 ? 216 ASP B O 1 ATOM 3611 C CB . ASP B 1 196 ? 39.055 -53.086 -2.164 1.00 24.47 ? 216 ASP B CB 1 ATOM 3612 C CG . ASP B 1 196 ? 38.654 -54.563 -2.075 1.00 24.47 ? 216 ASP B CG 1 ATOM 3613 O OD1 . ASP B 1 196 ? 38.848 -55.185 -1.025 1.00 24.55 ? 216 ASP B OD1 1 ATOM 3614 O OD2 . ASP B 1 196 ? 38.252 -55.099 -3.121 1.00 26.93 ? 216 ASP B OD2 1 ATOM 3615 N N . ILE B 1 197 ? 40.994 -53.695 0.797 1.00 22.62 ? 217 ILE B N 1 ATOM 3616 C CA . ILE B 1 197 ? 42.161 -54.416 1.362 1.00 21.19 ? 217 ILE B CA 1 ATOM 3617 C C . ILE B 1 197 ? 42.433 -55.744 0.648 1.00 22.03 ? 217 ILE B C 1 ATOM 3618 O O . ILE B 1 197 ? 43.594 -56.181 0.569 1.00 21.93 ? 217 ILE B O 1 ATOM 3619 C CB . ILE B 1 197 ? 42.033 -54.609 2.884 1.00 24.02 ? 217 ILE B CB 1 ATOM 3620 C CG1 . ILE B 1 197 ? 43.374 -54.986 3.526 1.00 24.92 ? 217 ILE B CG1 1 ATOM 3621 C CG2 . ILE B 1 197 ? 40.977 -55.669 3.239 1.00 25.80 ? 217 ILE B CG2 1 ATOM 3622 C CD1 . ILE B 1 197 ? 44.562 -54.065 3.219 1.00 24.73 ? 217 ILE B CD1 1 ATOM 3623 N N . LYS B 1 198 ? 41.390 -56.324 0.023 1.00 21.96 ? 218 LYS B N 1 ATOM 3624 C CA A LYS B 1 198 ? 41.577 -57.570 -0.728 0.50 23.58 ? 218 LYS B CA 1 ATOM 3625 C CA B LYS B 1 198 ? 41.537 -57.577 -0.740 0.50 23.46 ? 218 LYS B CA 1 ATOM 3626 C C . LYS B 1 198 ? 42.064 -57.343 -2.161 1.00 22.82 ? 218 LYS B C 1 ATOM 3627 O O . LYS B 1 198 ? 42.330 -58.279 -2.880 1.00 19.84 ? 218 LYS B O 1 ATOM 3628 C CB A LYS B 1 198 ? 40.289 -58.400 -0.723 0.50 26.07 ? 218 LYS B CB 1 ATOM 3629 C CB B LYS B 1 198 ? 40.192 -58.317 -0.868 0.50 25.95 ? 218 LYS B CB 1 ATOM 3630 C CG A LYS B 1 198 ? 39.860 -58.862 0.679 0.50 28.90 ? 218 LYS B CG 1 ATOM 3631 C CG B LYS B 1 198 ? 39.502 -58.753 0.414 0.50 28.69 ? 218 LYS B CG 1 ATOM 3632 C CD A LYS B 1 198 ? 40.863 -59.815 1.342 0.50 31.20 ? 218 LYS B CD 1 ATOM 3633 C CD B LYS B 1 198 ? 38.244 -59.548 0.067 0.50 30.67 ? 218 LYS B CD 1 ATOM 3634 C CE A LYS B 1 198 ? 40.276 -60.555 2.544 0.50 34.64 ? 218 LYS B CE 1 ATOM 3635 C CE B LYS B 1 198 ? 37.546 -60.074 1.308 0.50 34.34 ? 218 LYS B CE 1 ATOM 3636 N NZ A LYS B 1 198 ? 39.968 -59.603 3.654 0.50 35.94 ? 218 LYS B NZ 1 ATOM 3637 N NZ B LYS B 1 198 ? 38.536 -60.545 2.312 0.50 37.03 ? 218 LYS B NZ 1 ATOM 3638 N N . ASP B 1 199 ? 42.199 -56.087 -2.572 1.00 21.50 ? 219 ASP B N 1 ATOM 3639 C CA . ASP B 1 199 ? 42.632 -55.771 -3.928 1.00 21.08 ? 219 ASP B CA 1 ATOM 3640 C C . ASP B 1 199 ? 43.584 -54.536 -3.932 1.00 20.39 ? 219 ASP B C 1 ATOM 3641 O O . ASP B 1 199 ? 43.201 -53.429 -4.306 1.00 18.62 ? 219 ASP B O 1 ATOM 3642 C CB . ASP B 1 199 ? 41.404 -55.566 -4.835 1.00 21.88 ? 219 ASP B CB 1 ATOM 3643 C CG . ASP B 1 199 ? 41.784 -55.598 -6.329 1.00 23.39 ? 219 ASP B CG 1 ATOM 3644 O OD1 . ASP B 1 199 ? 42.988 -55.586 -6.668 1.00 22.72 ? 219 ASP B OD1 1 ATOM 3645 O OD2 . ASP B 1 199 ? 40.897 -55.610 -7.170 1.00 26.54 ? 219 ASP B OD2 1 ATOM 3646 N N . PRO B 1 200 ? 44.834 -54.755 -3.487 1.00 20.01 ? 220 PRO B N 1 ATOM 3647 C CA . PRO B 1 200 ? 45.792 -53.683 -3.440 1.00 19.49 ? 220 PRO B CA 1 ATOM 3648 C C . PRO B 1 200 ? 46.109 -53.063 -4.794 1.00 17.41 ? 220 PRO B C 1 ATOM 3649 O O . PRO B 1 200 ? 46.300 -51.874 -4.870 1.00 15.26 ? 220 PRO B O 1 ATOM 3650 C CB . PRO B 1 200 ? 47.055 -54.337 -2.835 1.00 20.60 ? 220 PRO B CB 1 ATOM 3651 C CG . PRO B 1 200 ? 46.561 -55.577 -2.161 1.00 22.12 ? 220 PRO B CG 1 ATOM 3652 C CD . PRO B 1 200 ? 45.353 -56.016 -2.903 1.00 20.98 ? 220 PRO B CD 1 ATOM 3653 N N . VAL B 1 201 ? 46.108 -53.862 -5.851 1.00 17.19 ? 221 VAL B N 1 ATOM 3654 C CA . VAL B 1 201 ? 46.311 -53.323 -7.178 1.00 16.54 ? 221 VAL B CA 1 ATOM 3655 C C . VAL B 1 201 ? 45.256 -52.306 -7.524 1.00 17.58 ? 221 VAL B C 1 ATOM 3656 O O . VAL B 1 201 ? 45.577 -51.146 -7.879 1.00 15.96 ? 221 VAL B O 1 ATOM 3657 C CB . VAL B 1 201 ? 46.466 -54.440 -8.226 1.00 17.76 ? 221 VAL B CB 1 ATOM 3658 C CG1 . VAL B 1 201 ? 46.539 -53.873 -9.655 1.00 18.68 ? 221 VAL B CG1 1 ATOM 3659 C CG2 . VAL B 1 201 ? 47.771 -55.203 -7.952 1.00 17.54 ? 221 VAL B CG2 1 ATOM 3660 N N . SER B 1 202 ? 43.977 -52.741 -7.502 1.00 17.77 ? 222 SER B N 1 ATOM 3661 C CA . SER B 1 202 ? 42.865 -51.827 -7.832 1.00 16.94 ? 222 SER B CA 1 ATOM 3662 C C . SER B 1 202 ? 42.870 -50.594 -6.945 1.00 15.56 ? 222 SER B C 1 ATOM 3663 O O . SER B 1 202 ? 42.693 -49.473 -7.430 1.00 13.64 ? 222 SER B O 1 ATOM 3664 C CB . SER B 1 202 ? 41.494 -52.523 -7.787 1.00 17.81 ? 222 SER B CB 1 ATOM 3665 O OG . SER B 1 202 ? 41.483 -53.620 -8.697 1.00 19.03 ? 222 SER B OG 1 ATOM 3666 N N . THR B 1 203 ? 43.138 -50.802 -5.650 1.00 15.52 ? 223 THR B N 1 ATOM 3667 C CA . THR B 1 203 ? 43.122 -49.714 -4.728 1.00 15.17 ? 223 THR B CA 1 ATOM 3668 C C . THR B 1 203 ? 44.226 -48.695 -5.020 1.00 14.93 ? 223 THR B C 1 ATOM 3669 O O . THR B 1 203 ? 43.963 -47.511 -5.119 1.00 15.91 ? 223 THR B O 1 ATOM 3670 C CB . THR B 1 203 ? 43.238 -50.182 -3.275 1.00 16.39 ? 223 THR B CB 1 ATOM 3671 O OG1 . THR B 1 203 ? 42.116 -51.016 -2.935 1.00 16.46 ? 223 THR B OG1 1 ATOM 3672 C CG2 . THR B 1 203 ? 43.310 -48.975 -2.356 1.00 17.11 ? 223 THR B CG2 1 ATOM 3673 N N . SER B 1 204 ? 45.464 -49.146 -5.165 1.00 14.70 ? 224 SER B N 1 ATOM 3674 C CA . SER B 1 204 ? 46.550 -48.210 -5.379 1.00 15.39 ? 224 SER B CA 1 ATOM 3675 C C . SER B 1 204 ? 46.465 -47.542 -6.770 1.00 15.24 ? 224 SER B C 1 ATOM 3676 O O . SER B 1 204 ? 46.936 -46.394 -6.960 1.00 14.00 ? 224 SER B O 1 ATOM 3677 C CB . SER B 1 204 ? 47.922 -48.858 -5.089 1.00 15.03 ? 224 SER B CB 1 ATOM 3678 O OG . SER B 1 204 ? 48.182 -49.994 -5.861 1.00 14.49 ? 224 SER B OG 1 ATOM 3679 N N . MET B 1 205 ? 45.856 -48.263 -7.731 1.00 14.97 ? 225 MET B N 1 ATOM 3680 C CA . MET B 1 205 ? 45.611 -47.713 -9.044 1.00 14.56 ? 225 MET B CA 1 ATOM 3681 C C . MET B 1 205 ? 44.709 -46.506 -8.975 1.00 14.05 ? 225 MET B C 1 ATOM 3682 O O . MET B 1 205 ? 44.889 -45.586 -9.770 1.00 12.99 ? 225 MET B O 1 ATOM 3683 C CB . MET B 1 205 ? 45.097 -48.764 -10.038 1.00 15.24 ? 225 MET B CB 1 ATOM 3684 C CG . MET B 1 205 ? 46.205 -49.636 -10.655 1.00 15.80 ? 225 MET B CG 1 ATOM 3685 S SD . MET B 1 205 ? 47.366 -48.724 -11.680 1.00 18.06 ? 225 MET B SD 1 ATOM 3686 C CE . MET B 1 205 ? 46.289 -48.179 -13.026 1.00 18.77 ? 225 MET B CE 1 ATOM 3687 N N . ILE B 1 206 ? 43.732 -46.476 -8.047 1.00 13.01 ? 226 ILE B N 1 ATOM 3688 C CA . ILE B 1 206 ? 42.915 -45.260 -7.897 1.00 12.40 ? 226 ILE B CA 1 ATOM 3689 C C . ILE B 1 206 ? 43.830 -44.063 -7.617 1.00 12.96 ? 226 ILE B C 1 ATOM 3690 O O . ILE B 1 206 ? 43.661 -42.969 -8.171 1.00 12.41 ? 226 ILE B O 1 ATOM 3691 C CB . ILE B 1 206 ? 41.895 -45.376 -6.722 1.00 13.08 ? 226 ILE B CB 1 ATOM 3692 C CG1 . ILE B 1 206 ? 40.886 -46.515 -6.981 1.00 14.17 ? 226 ILE B CG1 1 ATOM 3693 C CG2 . ILE B 1 206 ? 41.124 -44.090 -6.513 1.00 12.37 ? 226 ILE B CG2 1 ATOM 3694 C CD1 . ILE B 1 206 ? 40.034 -46.889 -5.774 1.00 13.81 ? 226 ILE B CD1 1 ATOM 3695 N N . TRP B 1 207 ? 44.727 -44.276 -6.666 1.00 13.65 ? 227 TRP B N 1 ATOM 3696 C CA . TRP B 1 207 ? 45.570 -43.202 -6.164 1.00 14.06 ? 227 TRP B CA 1 ATOM 3697 C C . TRP B 1 207 ? 46.567 -42.741 -7.259 1.00 13.40 ? 227 TRP B C 1 ATOM 3698 O O . TRP B 1 207 ? 46.702 -41.544 -7.482 1.00 13.67 ? 227 TRP B O 1 ATOM 3699 C CB . TRP B 1 207 ? 46.291 -43.638 -4.870 1.00 14.33 ? 227 TRP B CB 1 ATOM 3700 C CG . TRP B 1 207 ? 45.390 -44.153 -3.844 1.00 15.78 ? 227 TRP B CG 1 ATOM 3701 C CD1 . TRP B 1 207 ? 44.044 -43.874 -3.699 1.00 17.02 ? 227 TRP B CD1 1 ATOM 3702 C CD2 . TRP B 1 207 ? 45.713 -45.053 -2.794 1.00 16.30 ? 227 TRP B CD2 1 ATOM 3703 N NE1 . TRP B 1 207 ? 43.548 -44.548 -2.621 1.00 17.29 ? 227 TRP B NE1 1 ATOM 3704 C CE2 . TRP B 1 207 ? 44.551 -45.244 -2.033 1.00 16.15 ? 227 TRP B CE2 1 ATOM 3705 C CE3 . TRP B 1 207 ? 46.870 -45.716 -2.427 1.00 17.14 ? 227 TRP B CE3 1 ATOM 3706 C CZ2 . TRP B 1 207 ? 44.509 -46.045 -0.930 1.00 17.92 ? 227 TRP B CZ2 1 ATOM 3707 C CZ3 . TRP B 1 207 ? 46.830 -46.539 -1.304 1.00 18.35 ? 227 TRP B CZ3 1 ATOM 3708 C CH2 . TRP B 1 207 ? 45.657 -46.685 -0.572 1.00 17.39 ? 227 TRP B CH2 1 ATOM 3709 N N . ALA B 1 208 ? 47.152 -43.687 -7.968 1.00 13.08 ? 228 ALA B N 1 ATOM 3710 C CA . ALA B 1 208 ? 48.006 -43.381 -9.125 1.00 14.16 ? 228 ALA B CA 1 ATOM 3711 C C . ALA B 1 208 ? 47.269 -42.613 -10.233 1.00 13.85 ? 228 ALA B C 1 ATOM 3712 O O . ALA B 1 208 ? 47.748 -41.609 -10.728 1.00 13.14 ? 228 ALA B O 1 ATOM 3713 C CB . ALA B 1 208 ? 48.633 -44.646 -9.698 1.00 13.61 ? 228 ALA B CB 1 ATOM 3714 N N . ALA B 1 209 ? 46.062 -43.085 -10.578 1.00 14.40 ? 229 ALA B N 1 ATOM 3715 C CA . ALA B 1 209 ? 45.253 -42.422 -11.583 1.00 13.91 ? 229 ALA B CA 1 ATOM 3716 C C . ALA B 1 209 ? 44.920 -41.009 -11.180 1.00 13.31 ? 229 ALA B C 1 ATOM 3717 O O . ALA B 1 209 ? 44.960 -40.095 -12.000 1.00 12.00 ? 229 ALA B O 1 ATOM 3718 C CB . ALA B 1 209 ? 43.962 -43.221 -11.878 1.00 14.55 ? 229 ALA B CB 1 ATOM 3719 N N . ASP B 1 210 ? 44.589 -40.834 -9.892 1.00 12.75 ? 230 ASP B N 1 ATOM 3720 C CA . ASP B 1 210 ? 44.189 -39.554 -9.328 1.00 13.68 ? 230 ASP B CA 1 ATOM 3721 C C . ASP B 1 210 ? 45.367 -38.566 -9.463 1.00 13.79 ? 230 ASP B C 1 ATOM 3722 O O . ASP B 1 210 ? 45.210 -37.505 -10.093 1.00 12.74 ? 230 ASP B O 1 ATOM 3723 C CB . ASP B 1 210 ? 43.802 -39.773 -7.871 1.00 14.48 ? 230 ASP B CB 1 ATOM 3724 C CG . ASP B 1 210 ? 43.098 -38.592 -7.196 1.00 15.20 ? 230 ASP B CG 1 ATOM 3725 O OD1 . ASP B 1 210 ? 42.549 -37.660 -7.773 1.00 16.33 ? 230 ASP B OD1 1 ATOM 3726 O OD2 . ASP B 1 210 ? 43.134 -38.644 -5.956 1.00 17.58 ? 230 ASP B OD2 1 ATOM 3727 N N . ALA B 1 211 ? 46.542 -38.960 -8.953 1.00 13.86 ? 231 ALA B N 1 ATOM 3728 C CA . ALA B 1 211 ? 47.756 -38.083 -9.077 1.00 14.38 ? 231 ALA B CA 1 ATOM 3729 C C . ALA B 1 211 ? 48.125 -37.858 -10.576 1.00 13.04 ? 231 ALA B C 1 ATOM 3730 O O . ALA B 1 211 ? 48.454 -36.763 -10.952 1.00 11.43 ? 231 ALA B O 1 ATOM 3731 C CB . ALA B 1 211 ? 48.954 -38.700 -8.340 1.00 14.05 ? 231 ALA B CB 1 ATOM 3732 N N . ASN B 1 212 ? 47.971 -38.909 -11.399 1.00 12.00 ? 232 ASN B N 1 ATOM 3733 C CA . ASN B 1 212 ? 48.252 -38.800 -12.855 1.00 12.74 ? 232 ASN B CA 1 ATOM 3734 C C . ASN B 1 212 ? 47.426 -37.757 -13.568 1.00 13.47 ? 232 ASN B C 1 ATOM 3735 O O . ASN B 1 212 ? 47.921 -37.055 -14.438 1.00 13.71 ? 232 ASN B O 1 ATOM 3736 C CB . ASN B 1 212 ? 48.116 -40.179 -13.526 1.00 14.05 ? 232 ASN B CB 1 ATOM 3737 C CG . ASN B 1 212 ? 48.201 -40.122 -15.039 1.00 14.48 ? 232 ASN B CG 1 ATOM 3738 O OD1 . ASN B 1 212 ? 47.177 -40.039 -15.703 1.00 14.01 ? 232 ASN B OD1 1 ATOM 3739 N ND2 . ASN B 1 212 ? 49.420 -40.108 -15.587 1.00 14.36 ? 232 ASN B ND2 1 ATOM 3740 N N . THR B 1 213 ? 46.159 -37.576 -13.184 1.00 13.14 ? 233 THR B N 1 ATOM 3741 C CA . THR B 1 213 ? 45.382 -36.541 -13.847 1.00 13.80 ? 233 THR B CA 1 ATOM 3742 C C . THR B 1 213 ? 46.016 -35.138 -13.681 1.00 13.35 ? 233 THR B C 1 ATOM 3743 O O . THR B 1 213 ? 45.834 -34.269 -14.556 1.00 12.46 ? 233 THR B O 1 ATOM 3744 C CB . THR B 1 213 ? 43.901 -36.434 -13.351 1.00 14.09 ? 233 THR B CB 1 ATOM 3745 O OG1 . THR B 1 213 ? 43.879 -35.986 -11.981 1.00 14.67 ? 233 THR B OG1 1 ATOM 3746 C CG2 . THR B 1 213 ? 43.160 -37.774 -13.514 1.00 14.41 ? 233 THR B CG2 1 ATOM 3747 N N . TYR B 1 214 ? 46.700 -34.914 -12.557 1.00 12.54 ? 234 TYR B N 1 ATOM 3748 C CA . TYR B 1 214 ? 47.345 -33.637 -12.299 1.00 13.84 ? 234 TYR B CA 1 ATOM 3749 C C . TYR B 1 214 ? 48.598 -33.392 -13.140 1.00 13.29 ? 234 TYR B C 1 ATOM 3750 O O . TYR B 1 214 ? 49.021 -32.257 -13.291 1.00 13.81 ? 234 TYR B O 1 ATOM 3751 C CB . TYR B 1 214 ? 47.661 -33.444 -10.787 1.00 13.78 ? 234 TYR B CB 1 ATOM 3752 C CG . TYR B 1 214 ? 46.400 -33.284 -9.992 1.00 13.32 ? 234 TYR B CG 1 ATOM 3753 C CD1 . TYR B 1 214 ? 45.817 -32.035 -9.831 1.00 13.52 ? 234 TYR B CD1 1 ATOM 3754 C CD2 . TYR B 1 214 ? 45.804 -34.378 -9.371 1.00 13.92 ? 234 TYR B CD2 1 ATOM 3755 C CE1 . TYR B 1 214 ? 44.640 -31.878 -9.095 1.00 14.52 ? 234 TYR B CE1 1 ATOM 3756 C CE2 . TYR B 1 214 ? 44.654 -34.243 -8.624 1.00 13.24 ? 234 TYR B CE2 1 ATOM 3757 C CZ . TYR B 1 214 ? 44.064 -32.999 -8.499 1.00 14.49 ? 234 TYR B CZ 1 ATOM 3758 O OH . TYR B 1 214 ? 42.903 -32.834 -7.795 1.00 15.21 ? 234 TYR B OH 1 ATOM 3759 N N . VAL B 1 215 ? 49.179 -34.456 -13.689 1.00 13.40 ? 235 VAL B N 1 ATOM 3760 C CA . VAL B 1 215 ? 50.204 -34.251 -14.736 1.00 13.68 ? 235 VAL B CA 1 ATOM 3761 C C . VAL B 1 215 ? 49.662 -33.381 -15.868 1.00 14.95 ? 235 VAL B C 1 ATOM 3762 O O . VAL B 1 215 ? 50.340 -32.425 -16.320 1.00 14.49 ? 235 VAL B O 1 ATOM 3763 C CB . VAL B 1 215 ? 50.724 -35.575 -15.275 1.00 13.48 ? 235 VAL B CB 1 ATOM 3764 C CG1 . VAL B 1 215 ? 51.754 -35.334 -16.356 1.00 13.88 ? 235 VAL B CG1 1 ATOM 3765 C CG2 . VAL B 1 215 ? 51.328 -36.456 -14.154 1.00 12.64 ? 235 VAL B CG2 1 ATOM 3766 N N . CYS B 1 216 ? 48.442 -33.716 -16.332 1.00 14.28 ? 236 CYS B N 1 ATOM 3767 C CA . CYS B 1 216 ? 47.759 -32.933 -17.354 1.00 14.56 ? 236 CYS B CA 1 ATOM 3768 C C . CYS B 1 216 ? 47.172 -31.622 -16.856 1.00 15.14 ? 236 CYS B C 1 ATOM 3769 O O . CYS B 1 216 ? 47.316 -30.600 -17.522 1.00 16.11 ? 236 CYS B O 1 ATOM 3770 C CB . CYS B 1 216 ? 46.654 -33.745 -18.049 1.00 15.74 ? 236 CYS B CB 1 ATOM 3771 S SG . CYS B 1 216 ? 47.315 -35.011 -19.139 1.00 16.88 ? 236 CYS B SG 1 ATOM 3772 N N . SER B 1 217 ? 46.535 -31.600 -15.689 1.00 14.34 ? 237 SER B N 1 ATOM 3773 C CA . SER B 1 217 ? 45.843 -30.387 -15.264 1.00 15.25 ? 237 SER B CA 1 ATOM 3774 C C . SER B 1 217 ? 46.792 -29.309 -14.675 1.00 16.44 ? 237 SER B C 1 ATOM 3775 O O . SER B 1 217 ? 46.465 -28.133 -14.710 1.00 15.00 ? 237 SER B O 1 ATOM 3776 C CB . SER B 1 217 ? 44.778 -30.709 -14.224 1.00 16.35 ? 237 SER B CB 1 ATOM 3777 O OG . SER B 1 217 ? 45.339 -31.024 -12.935 1.00 16.18 ? 237 SER B OG 1 ATOM 3778 N N . THR B 1 218 ? 47.958 -29.725 -14.151 1.00 14.38 ? 238 THR B N 1 ATOM 3779 C CA . THR B 1 218 ? 48.787 -28.848 -13.381 1.00 14.32 ? 238 THR B CA 1 ATOM 3780 C C . THR B 1 218 ? 50.288 -28.870 -13.709 1.00 13.95 ? 238 THR B C 1 ATOM 3781 O O . THR B 1 218 ? 50.895 -27.819 -13.882 1.00 14.91 ? 238 THR B O 1 ATOM 3782 C CB . THR B 1 218 ? 48.571 -29.133 -11.874 1.00 14.73 ? 238 THR B CB 1 ATOM 3783 O OG1 . THR B 1 218 ? 47.162 -29.159 -11.610 1.00 14.93 ? 238 THR B OG1 1 ATOM 3784 C CG2 . THR B 1 218 ? 49.236 -28.052 -11.047 1.00 14.66 ? 238 THR B CG2 1 ATOM 3785 N N . VAL B 1 219 ? 50.871 -30.064 -13.749 1.00 13.65 ? 239 VAL B N 1 ATOM 3786 C CA . VAL B 1 219 ? 52.315 -30.203 -13.914 1.00 13.41 ? 239 VAL B CA 1 ATOM 3787 C C . VAL B 1 219 ? 52.773 -29.685 -15.275 1.00 13.79 ? 239 VAL B C 1 ATOM 3788 O O . VAL B 1 219 ? 53.704 -28.882 -15.383 1.00 13.33 ? 239 VAL B O 1 ATOM 3789 C CB . VAL B 1 219 ? 52.773 -31.636 -13.766 1.00 13.85 ? 239 VAL B CB 1 ATOM 3790 C CG1 . VAL B 1 219 ? 54.272 -31.741 -13.967 1.00 15.27 ? 239 VAL B CG1 1 ATOM 3791 C CG2 . VAL B 1 219 ? 52.426 -32.168 -12.376 1.00 14.31 ? 239 VAL B CG2 1 ATOM 3792 N N . LEU B 1 220 ? 52.072 -30.134 -16.307 1.00 14.89 ? 240 LEU B N 1 ATOM 3793 C CA . LEU B 1 220 ? 52.464 -29.860 -17.685 1.00 16.24 ? 240 LEU B CA 1 ATOM 3794 C C . LEU B 1 220 ? 51.507 -28.950 -18.468 1.00 17.72 ? 240 LEU B C 1 ATOM 3795 O O . LEU B 1 220 ? 51.786 -28.681 -19.637 1.00 18.40 ? 240 LEU B O 1 ATOM 3796 C CB . LEU B 1 220 ? 52.739 -31.187 -18.428 1.00 15.87 ? 240 LEU B CB 1 ATOM 3797 C CG . LEU B 1 220 ? 53.961 -31.968 -17.974 1.00 16.58 ? 240 LEU B CG 1 ATOM 3798 C CD1 . LEU B 1 220 ? 54.104 -33.313 -18.664 1.00 17.88 ? 240 LEU B CD1 1 ATOM 3799 C CD2 . LEU B 1 220 ? 55.247 -31.248 -18.130 1.00 17.72 ? 240 LEU B CD2 1 ATOM 3800 N N . ASP B 1 221 ? 50.415 -28.451 -17.874 1.00 19.30 ? 241 ASP B N 1 ATOM 3801 C CA . ASP B 1 221 ? 49.400 -27.757 -18.705 1.00 24.37 ? 241 ASP B CA 1 ATOM 3802 C C . ASP B 1 221 ? 49.847 -26.416 -19.345 1.00 23.98 ? 241 ASP B C 1 ATOM 3803 O O . ASP B 1 221 ? 49.314 -26.042 -20.382 1.00 24.48 ? 241 ASP B O 1 ATOM 3804 C CB . ASP B 1 221 ? 48.046 -27.560 -18.003 1.00 26.80 ? 241 ASP B CB 1 ATOM 3805 C CG . ASP B 1 221 ? 48.145 -26.658 -16.890 1.00 30.80 ? 241 ASP B CG 1 ATOM 3806 O OD1 . ASP B 1 221 ? 49.149 -26.849 -16.150 1.00 30.54 ? 241 ASP B OD1 1 ATOM 3807 O OD2 . ASP B 1 221 ? 47.268 -25.748 -16.773 1.00 33.12 ? 241 ASP B OD2 1 ATOM 3808 N N . ASP B 1 222 ? 50.825 -25.737 -18.765 1.00 22.72 ? 242 ASP B N 1 ATOM 3809 C CA . ASP B 1 222 ? 51.433 -24.543 -19.381 1.00 23.87 ? 242 ASP B CA 1 ATOM 3810 C C . ASP B 1 222 ? 52.174 -24.838 -20.696 1.00 23.66 ? 242 ASP B C 1 ATOM 3811 O O . ASP B 1 222 ? 52.411 -23.915 -21.520 1.00 22.21 ? 242 ASP B O 1 ATOM 3812 C CB . ASP B 1 222 ? 52.424 -23.841 -18.437 1.00 26.95 ? 242 ASP B CB 1 ATOM 3813 C CG . ASP B 1 222 ? 51.771 -23.313 -17.181 1.00 31.54 ? 242 ASP B CG 1 ATOM 3814 O OD1 . ASP B 1 222 ? 50.732 -22.627 -17.234 1.00 39.71 ? 242 ASP B OD1 1 ATOM 3815 O OD2 . ASP B 1 222 ? 52.237 -23.641 -16.124 1.00 33.00 ? 242 ASP B OD2 1 ATOM 3816 N N . GLY B 1 223 ? 52.588 -26.099 -20.860 1.00 22.72 ? 243 GLY B N 1 ATOM 3817 C CA . GLY B 1 223 ? 53.327 -26.541 -22.021 1.00 20.47 ? 243 GLY B CA 1 ATOM 3818 C C . GLY B 1 223 ? 54.827 -26.440 -21.805 1.00 20.06 ? 243 GLY B C 1 ATOM 3819 O O . GLY B 1 223 ? 55.345 -25.620 -21.019 1.00 18.58 ? 243 GLY B O 1 ATOM 3820 N N . LEU B 1 224 ? 55.535 -27.277 -22.525 1.00 21.38 ? 244 LEU B N 1 ATOM 3821 C CA . LEU B 1 224 ? 56.993 -27.340 -22.384 1.00 23.34 ? 244 LEU B CA 1 ATOM 3822 C C . LEU B 1 224 ? 57.742 -26.055 -22.752 1.00 24.37 ? 244 LEU B C 1 ATOM 3823 O O . LEU B 1 224 ? 58.800 -25.819 -22.184 1.00 23.33 ? 244 LEU B O 1 ATOM 3824 C CB . LEU B 1 224 ? 57.558 -28.526 -23.141 1.00 23.68 ? 244 LEU B CB 1 ATOM 3825 C CG . LEU B 1 224 ? 57.163 -29.933 -22.614 1.00 25.37 ? 244 LEU B CG 1 ATOM 3826 C CD1 . LEU B 1 224 ? 57.759 -30.996 -23.521 1.00 27.20 ? 244 LEU B CD1 1 ATOM 3827 C CD2 . LEU B 1 224 ? 57.631 -30.178 -21.199 1.00 27.79 ? 244 LEU B CD2 1 ATOM 3828 N N . ALA B 1 225 ? 57.224 -25.244 -23.689 1.00 22.64 ? 245 ALA B N 1 ATOM 3829 C CA . ALA B 1 225 ? 57.923 -24.009 -24.044 1.00 22.90 ? 245 ALA B CA 1 ATOM 3830 C C . ALA B 1 225 ? 57.952 -23.030 -22.888 1.00 20.73 ? 245 ALA B C 1 ATOM 3831 O O . ALA B 1 225 ? 59.009 -22.481 -22.555 1.00 21.51 ? 245 ALA B O 1 ATOM 3832 C CB . ALA B 1 225 ? 57.350 -23.353 -25.298 1.00 24.21 ? 245 ALA B CB 1 ATOM 3833 N N . TYR B 1 226 ? 56.810 -22.849 -22.226 1.00 18.79 ? 246 TYR B N 1 ATOM 3834 C CA . TYR B 1 226 ? 56.775 -22.074 -20.993 1.00 18.58 ? 246 TYR B CA 1 ATOM 3835 C C . TYR B 1 226 ? 57.685 -22.673 -19.887 1.00 19.16 ? 246 TYR B C 1 ATOM 3836 O O . TYR B 1 226 ? 58.499 -21.982 -19.272 1.00 20.15 ? 246 TYR B O 1 ATOM 3837 C CB . TYR B 1 226 ? 55.346 -22.008 -20.489 1.00 20.81 ? 246 TYR B CB 1 ATOM 3838 C CG . TYR B 1 226 ? 55.218 -21.295 -19.154 1.00 21.76 ? 246 TYR B CG 1 ATOM 3839 C CD1 . TYR B 1 226 ? 55.333 -21.996 -17.971 1.00 20.05 ? 246 TYR B CD1 1 ATOM 3840 C CD2 . TYR B 1 226 ? 54.946 -19.899 -19.095 1.00 22.78 ? 246 TYR B CD2 1 ATOM 3841 C CE1 . TYR B 1 226 ? 55.246 -21.344 -16.762 1.00 19.50 ? 246 TYR B CE1 1 ATOM 3842 C CE2 . TYR B 1 226 ? 54.846 -19.230 -17.889 1.00 21.87 ? 246 TYR B CE2 1 ATOM 3843 C CZ . TYR B 1 226 ? 54.994 -19.974 -16.708 1.00 22.67 ? 246 TYR B CZ 1 ATOM 3844 O OH . TYR B 1 226 ? 54.839 -19.392 -15.482 1.00 21.73 ? 246 TYR B OH 1 ATOM 3845 N N . ILE B 1 227 ? 57.528 -23.968 -19.652 1.00 19.64 ? 247 ILE B N 1 ATOM 3846 C CA . ILE B 1 227 ? 58.244 -24.673 -18.590 1.00 20.83 ? 247 ILE B CA 1 ATOM 3847 C C . ILE B 1 227 ? 59.749 -24.653 -18.730 1.00 22.54 ? 247 ILE B C 1 ATOM 3848 O O . ILE B 1 227 ? 60.486 -24.520 -17.738 1.00 22.17 ? 247 ILE B O 1 ATOM 3849 C CB . ILE B 1 227 ? 57.750 -26.117 -18.491 1.00 22.56 ? 247 ILE B CB 1 ATOM 3850 C CG1 . ILE B 1 227 ? 56.414 -26.097 -17.762 1.00 26.34 ? 247 ILE B CG1 1 ATOM 3851 C CG2 . ILE B 1 227 ? 58.746 -27.014 -17.740 1.00 24.40 ? 247 ILE B CG2 1 ATOM 3852 C CD1 . ILE B 1 227 ? 55.671 -27.403 -17.906 1.00 28.90 ? 247 ILE B CD1 1 ATOM 3853 N N . ASN B 1 228 ? 60.244 -24.742 -19.971 1.00 21.77 ? 248 ASN B N 1 ATOM 3854 C CA . ASN B 1 228 ? 61.661 -24.792 -20.134 1.00 21.94 ? 248 ASN B CA 1 ATOM 3855 C C . ASN B 1 228 ? 62.264 -23.393 -20.246 1.00 23.75 ? 248 ASN B C 1 ATOM 3856 O O . ASN B 1 228 ? 63.454 -23.269 -20.291 1.00 23.19 ? 248 ASN B O 1 ATOM 3857 C CB . ASN B 1 228 ? 62.095 -25.778 -21.227 1.00 25.48 ? 248 ASN B CB 1 ATOM 3858 C CG . ASN B 1 228 ? 61.729 -25.342 -22.621 1.00 25.79 ? 248 ASN B CG 1 ATOM 3859 O OD1 . ASN B 1 228 ? 61.552 -24.153 -22.894 1.00 26.74 ? 248 ASN B OD1 1 ATOM 3860 N ND2 . ASN B 1 228 ? 61.600 -26.313 -23.526 1.00 30.13 ? 248 ASN B ND2 1 ATOM 3861 N N . SER B 1 229 ? 61.469 -22.333 -20.235 1.00 23.70 ? 249 SER B N 1 ATOM 3862 C CA . SER B 1 229 ? 62.015 -20.991 -20.455 1.00 23.79 ? 249 SER B CA 1 ATOM 3863 C C . SER B 1 229 ? 61.641 -19.972 -19.384 1.00 24.21 ? 249 SER B C 1 ATOM 3864 O O . SER B 1 229 ? 61.980 -18.805 -19.515 1.00 24.90 ? 249 SER B O 1 ATOM 3865 C CB . SER B 1 229 ? 61.542 -20.504 -21.808 1.00 24.48 ? 249 SER B CB 1 ATOM 3866 O OG . SER B 1 229 ? 60.155 -20.198 -21.726 1.00 25.16 ? 249 SER B OG 1 ATOM 3867 N N . THR B 1 230 ? 60.972 -20.390 -18.316 1.00 20.90 ? 250 THR B N 1 ATOM 3868 C CA . THR B 1 230 ? 60.477 -19.460 -17.299 1.00 20.22 ? 250 THR B CA 1 ATOM 3869 C C . THR B 1 230 ? 60.941 -19.941 -15.957 1.00 21.44 ? 250 THR B C 1 ATOM 3870 O O . THR B 1 230 ? 60.977 -21.156 -15.684 1.00 22.11 ? 250 THR B O 1 ATOM 3871 C CB . THR B 1 230 ? 58.942 -19.440 -17.299 1.00 21.44 ? 250 THR B CB 1 ATOM 3872 O OG1 . THR B 1 230 ? 58.467 -19.286 -18.634 1.00 23.18 ? 250 THR B OG1 1 ATOM 3873 C CG2 . THR B 1 230 ? 58.376 -18.346 -16.452 1.00 23.09 ? 250 THR B CG2 1 ATOM 3874 N N . ASP B 1 231 ? 61.321 -19.012 -15.111 1.00 21.80 ? 251 ASP B N 1 ATOM 3875 C CA . ASP B 1 231 ? 61.594 -19.342 -13.716 1.00 23.27 ? 251 ASP B CA 1 ATOM 3876 C C . ASP B 1 231 ? 60.285 -19.814 -13.025 1.00 21.09 ? 251 ASP B C 1 ATOM 3877 O O . ASP B 1 231 ? 59.331 -19.067 -12.889 1.00 21.67 ? 251 ASP B O 1 ATOM 3878 C CB . ASP B 1 231 ? 62.207 -18.167 -12.974 1.00 22.86 ? 251 ASP B CB 1 ATOM 3879 C CG . ASP B 1 231 ? 62.804 -18.591 -11.681 1.00 24.25 ? 251 ASP B CG 1 ATOM 3880 O OD1 . ASP B 1 231 ? 62.098 -19.191 -10.842 1.00 21.50 ? 251 ASP B OD1 1 ATOM 3881 O OD2 . ASP B 1 231 ? 64.023 -18.387 -11.506 1.00 28.91 ? 251 ASP B OD2 1 ATOM 3882 N N . LEU B 1 232 ? 60.289 -21.057 -12.565 1.00 18.82 ? 252 LEU B N 1 ATOM 3883 C CA . LEU B 1 232 ? 59.093 -21.699 -12.064 1.00 17.89 ? 252 LEU B CA 1 ATOM 3884 C C . LEU B 1 232 ? 58.811 -21.435 -10.591 1.00 17.33 ? 252 LEU B C 1 ATOM 3885 O O . LEU B 1 232 ? 57.786 -21.939 -10.074 1.00 16.59 ? 252 LEU B O 1 ATOM 3886 C CB . LEU B 1 232 ? 59.169 -23.211 -12.353 1.00 17.16 ? 252 LEU B CB 1 ATOM 3887 C CG . LEU B 1 232 ? 59.332 -23.543 -13.857 1.00 16.54 ? 252 LEU B CG 1 ATOM 3888 C CD1 . LEU B 1 232 ? 59.331 -25.052 -14.109 1.00 16.52 ? 252 LEU B CD1 1 ATOM 3889 C CD2 . LEU B 1 232 ? 58.232 -22.872 -14.730 1.00 16.86 ? 252 LEU B CD2 1 ATOM 3890 N N . SER B 1 233 ? 59.658 -20.629 -9.920 1.00 17.33 ? 253 SER B N 1 ATOM 3891 C CA . SER B 1 233 ? 59.332 -20.171 -8.554 1.00 17.64 ? 253 SER B CA 1 ATOM 3892 C C . SER B 1 233 ? 58.281 -19.058 -8.518 1.00 17.79 ? 253 SER B C 1 ATOM 3893 O O . SER B 1 233 ? 57.908 -18.630 -7.438 1.00 17.82 ? 253 SER B O 1 ATOM 3894 C CB . SER B 1 233 ? 60.560 -19.726 -7.793 1.00 18.66 ? 253 SER B CB 1 ATOM 3895 O OG . SER B 1 233 ? 61.185 -18.600 -8.419 1.00 18.63 ? 253 SER B OG 1 ATOM 3896 N N . GLY B 1 234 ? 57.812 -18.595 -9.675 1.00 18.56 ? 254 GLY B N 1 ATOM 3897 C CA . GLY B 1 234 ? 56.774 -17.536 -9.755 1.00 20.04 ? 254 GLY B CA 1 ATOM 3898 C C . GLY B 1 234 ? 55.357 -18.098 -9.811 1.00 19.76 ? 254 GLY B C 1 ATOM 3899 O O . GLY B 1 234 ? 54.940 -18.858 -8.962 1.00 20.35 ? 254 GLY B O 1 ATOM 3900 N N . GLU B 1 235 ? 54.664 -17.811 -10.897 1.00 21.24 ? 255 GLU B N 1 ATOM 3901 C CA . GLU B 1 235 ? 53.291 -18.280 -11.082 1.00 22.48 ? 255 GLU B CA 1 ATOM 3902 C C . GLU B 1 235 ? 53.116 -19.804 -11.086 1.00 18.80 ? 255 GLU B C 1 ATOM 3903 O O . GLU B 1 235 ? 52.075 -20.314 -10.703 1.00 17.25 ? 255 GLU B O 1 ATOM 3904 C CB . GLU B 1 235 ? 52.759 -17.755 -12.395 1.00 27.47 ? 255 GLU B CB 1 ATOM 3905 C CG . GLU B 1 235 ? 52.572 -16.249 -12.407 1.00 33.50 ? 255 GLU B CG 1 ATOM 3906 C CD . GLU B 1 235 ? 51.731 -15.798 -13.630 1.00 38.07 ? 255 GLU B CD 1 ATOM 3907 O OE1 . GLU B 1 235 ? 52.111 -16.077 -14.787 1.00 35.00 ? 255 GLU B OE1 1 ATOM 3908 O OE2 . GLU B 1 235 ? 50.651 -15.227 -13.410 1.00 42.62 ? 255 GLU B OE2 1 ATOM 3909 N N . TYR B 1 236 ? 54.119 -20.512 -11.568 1.00 17.12 ? 256 TYR B N 1 ATOM 3910 C CA . TYR B 1 236 ? 54.036 -21.955 -11.663 1.00 16.59 ? 256 TYR B CA 1 ATOM 3911 C C . TYR B 1 236 ? 53.978 -22.583 -10.240 1.00 15.67 ? 256 TYR B C 1 ATOM 3912 O O . TYR B 1 236 ? 53.116 -23.425 -9.948 1.00 14.93 ? 256 TYR B O 1 ATOM 3913 C CB . TYR B 1 236 ? 55.240 -22.489 -12.423 1.00 16.26 ? 256 TYR B CB 1 ATOM 3914 C CG . TYR B 1 236 ? 55.175 -23.990 -12.621 1.00 15.18 ? 256 TYR B CG 1 ATOM 3915 C CD1 . TYR B 1 236 ? 55.706 -24.868 -11.669 1.00 15.49 ? 256 TYR B CD1 1 ATOM 3916 C CD2 . TYR B 1 236 ? 54.569 -24.533 -13.772 1.00 16.16 ? 256 TYR B CD2 1 ATOM 3917 C CE1 . TYR B 1 236 ? 55.639 -26.261 -11.843 1.00 15.98 ? 256 TYR B CE1 1 ATOM 3918 C CE2 . TYR B 1 236 ? 54.511 -25.890 -13.971 1.00 16.81 ? 256 TYR B CE2 1 ATOM 3919 C CZ . TYR B 1 236 ? 55.045 -26.772 -13.003 1.00 16.35 ? 256 TYR B CZ 1 ATOM 3920 O OH . TYR B 1 236 ? 54.970 -28.151 -13.211 1.00 15.56 ? 256 TYR B OH 1 ATOM 3921 N N . TYR B 1 237 ? 54.862 -22.094 -9.366 1.00 15.17 ? 257 TYR B N 1 ATOM 3922 C CA . TYR B 1 237 ? 54.819 -22.434 -7.960 1.00 15.08 ? 257 TYR B CA 1 ATOM 3923 C C . TYR B 1 237 ? 53.476 -22.063 -7.339 1.00 16.09 ? 257 TYR B C 1 ATOM 3924 O O . TYR B 1 237 ? 52.857 -22.869 -6.634 1.00 15.08 ? 257 TYR B O 1 ATOM 3925 C CB . TYR B 1 237 ? 55.951 -21.739 -7.188 1.00 17.30 ? 257 TYR B CB 1 ATOM 3926 C CG . TYR B 1 237 ? 55.814 -21.822 -5.694 1.00 18.21 ? 257 TYR B CG 1 ATOM 3927 C CD1 . TYR B 1 237 ? 56.046 -23.009 -5.022 1.00 19.84 ? 257 TYR B CD1 1 ATOM 3928 C CD2 . TYR B 1 237 ? 55.408 -20.702 -4.931 1.00 20.44 ? 257 TYR B CD2 1 ATOM 3929 C CE1 . TYR B 1 237 ? 55.877 -23.095 -3.644 1.00 18.51 ? 257 TYR B CE1 1 ATOM 3930 C CE2 . TYR B 1 237 ? 55.251 -20.768 -3.557 1.00 19.85 ? 257 TYR B CE2 1 ATOM 3931 C CZ . TYR B 1 237 ? 55.504 -21.962 -2.913 1.00 20.44 ? 257 TYR B CZ 1 ATOM 3932 O OH . TYR B 1 237 ? 55.349 -22.056 -1.556 1.00 18.10 ? 257 TYR B OH 1 ATOM 3933 N N . ASP B 1 238 ? 52.992 -20.861 -7.622 1.00 17.16 ? 258 ASP B N 1 ATOM 3934 C CA . ASP B 1 238 ? 51.735 -20.407 -6.993 1.00 17.84 ? 258 ASP B CA 1 ATOM 3935 C C . ASP B 1 238 ? 50.582 -21.339 -7.304 1.00 17.03 ? 258 ASP B C 1 ATOM 3936 O O . ASP B 1 238 ? 49.732 -21.580 -6.485 1.00 17.40 ? 258 ASP B O 1 ATOM 3937 C CB . ASP B 1 238 ? 51.335 -18.981 -7.480 1.00 20.99 ? 258 ASP B CB 1 ATOM 3938 C CG . ASP B 1 238 ? 52.314 -17.889 -7.048 1.00 21.34 ? 258 ASP B CG 1 ATOM 3939 O OD1 . ASP B 1 238 ? 53.088 -18.047 -6.069 1.00 21.32 ? 258 ASP B OD1 1 ATOM 3940 O OD2 . ASP B 1 238 ? 52.328 -16.882 -7.778 1.00 27.06 ? 258 ASP B OD2 1 ATOM 3941 N N . LYS B 1 239 ? 50.465 -21.761 -8.552 1.00 17.35 ? 259 LYS B N 1 ATOM 3942 C CA . LYS B 1 239 ? 49.355 -22.637 -8.904 1.00 19.03 ? 259 LYS B CA 1 ATOM 3943 C C . LYS B 1 239 ? 49.633 -24.107 -8.527 1.00 17.46 ? 259 LYS B C 1 ATOM 3944 O O . LYS B 1 239 ? 48.689 -24.925 -8.416 1.00 16.02 ? 259 LYS B O 1 ATOM 3945 C CB . LYS B 1 239 ? 48.965 -22.497 -10.387 1.00 23.32 ? 259 LYS B CB 1 ATOM 3946 C CG . LYS B 1 239 ? 50.044 -22.832 -11.339 1.00 29.30 ? 259 LYS B CG 1 ATOM 3947 C CD . LYS B 1 239 ? 49.763 -24.130 -12.058 1.00 33.07 ? 259 LYS B CD 1 ATOM 3948 C CE . LYS B 1 239 ? 50.968 -24.566 -12.910 1.00 34.88 ? 259 LYS B CE 1 ATOM 3949 N NZ . LYS B 1 239 ? 50.488 -24.879 -14.277 1.00 36.14 ? 259 LYS B NZ 1 ATOM 3950 N N . SER B 1 240 ? 50.908 -24.461 -8.387 1.00 15.04 ? 260 SER B N 1 ATOM 3951 C CA . SER B 1 240 ? 51.286 -25.852 -8.020 1.00 15.68 ? 260 SER B CA 1 ATOM 3952 C C . SER B 1 240 ? 50.969 -26.148 -6.560 1.00 16.36 ? 260 SER B C 1 ATOM 3953 O O . SER B 1 240 ? 50.551 -27.248 -6.202 1.00 15.23 ? 260 SER B O 1 ATOM 3954 C CB . SER B 1 240 ? 52.774 -26.144 -8.284 1.00 15.60 ? 260 SER B CB 1 ATOM 3955 O OG . SER B 1 240 ? 53.050 -26.194 -9.676 1.00 16.34 ? 260 SER B OG 1 ATOM 3956 N N . GLN B 1 241 ? 51.243 -25.164 -5.709 1.00 17.24 ? 261 GLN B N 1 ATOM 3957 C CA . GLN B 1 241 ? 51.101 -25.346 -4.248 1.00 16.93 ? 261 GLN B CA 1 ATOM 3958 C C . GLN B 1 241 ? 49.771 -25.937 -3.736 1.00 15.68 ? 261 GLN B C 1 ATOM 3959 O O . GLN B 1 241 ? 49.787 -26.931 -3.035 1.00 15.22 ? 261 GLN B O 1 ATOM 3960 C CB . GLN B 1 241 ? 51.432 -24.027 -3.538 1.00 17.44 ? 261 GLN B CB 1 ATOM 3961 C CG . GLN B 1 241 ? 51.314 -24.084 -2.027 1.00 17.68 ? 261 GLN B CG 1 ATOM 3962 C CD . GLN B 1 241 ? 51.792 -22.840 -1.335 1.00 17.00 ? 261 GLN B CD 1 ATOM 3963 O OE1 . GLN B 1 241 ? 52.070 -21.811 -1.972 1.00 19.01 ? 261 GLN B OE1 1 ATOM 3964 N NE2 . GLN B 1 241 ? 51.863 -22.911 -0.013 1.00 16.53 ? 261 GLN B NE2 1 ATOM 3965 N N . PRO B 1 242 ? 48.621 -25.372 -4.118 1.00 16.62 ? 262 PRO B N 1 ATOM 3966 C CA . PRO B 1 242 ? 47.368 -26.007 -3.694 1.00 16.12 ? 262 PRO B CA 1 ATOM 3967 C C . PRO B 1 242 ? 47.197 -27.446 -4.171 1.00 15.66 ? 262 PRO B C 1 ATOM 3968 O O . PRO B 1 242 ? 46.584 -28.235 -3.486 1.00 15.48 ? 262 PRO B O 1 ATOM 3969 C CB . PRO B 1 242 ? 46.278 -25.104 -4.288 1.00 17.16 ? 262 PRO B CB 1 ATOM 3970 C CG . PRO B 1 242 ? 46.961 -24.394 -5.401 1.00 16.95 ? 262 PRO B CG 1 ATOM 3971 C CD . PRO B 1 242 ? 48.372 -24.162 -4.928 1.00 16.80 ? 262 PRO B CD 1 ATOM 3972 N N . VAL B 1 243 ? 47.768 -27.798 -5.318 1.00 15.30 ? 263 VAL B N 1 ATOM 3973 C CA . VAL B 1 243 ? 47.687 -29.173 -5.794 1.00 15.22 ? 263 VAL B CA 1 ATOM 3974 C C . VAL B 1 243 ? 48.552 -30.121 -4.982 1.00 14.57 ? 263 VAL B C 1 ATOM 3975 O O . VAL B 1 243 ? 48.067 -31.166 -4.531 1.00 13.15 ? 263 VAL B O 1 ATOM 3976 C CB . VAL B 1 243 ? 47.968 -29.231 -7.318 1.00 16.76 ? 263 VAL B CB 1 ATOM 3977 C CG1 . VAL B 1 243 ? 48.146 -30.660 -7.811 1.00 17.25 ? 263 VAL B CG1 1 ATOM 3978 C CG2 . VAL B 1 243 ? 46.818 -28.542 -8.053 1.00 17.68 ? 263 VAL B CG2 1 ATOM 3979 N N . PHE B 1 244 ? 49.849 -29.812 -4.840 1.00 14.11 ? 264 PHE B N 1 ATOM 3980 C CA . PHE B 1 244 ? 50.672 -30.724 -4.032 1.00 14.14 ? 264 PHE B CA 1 ATOM 3981 C C . PHE B 1 244 ? 50.229 -30.762 -2.584 1.00 13.67 ? 264 PHE B C 1 ATOM 3982 O O . PHE B 1 244 ? 50.330 -31.811 -1.949 1.00 12.56 ? 264 PHE B O 1 ATOM 3983 C CB . PHE B 1 244 ? 52.194 -30.583 -4.202 1.00 14.31 ? 264 PHE B CB 1 ATOM 3984 C CG . PHE B 1 244 ? 52.792 -29.226 -3.859 1.00 14.08 ? 264 PHE B CG 1 ATOM 3985 C CD1 . PHE B 1 244 ? 53.018 -28.852 -2.538 1.00 14.51 ? 264 PHE B CD1 1 ATOM 3986 C CD2 . PHE B 1 244 ? 53.301 -28.416 -4.864 1.00 14.87 ? 264 PHE B CD2 1 ATOM 3987 C CE1 . PHE B 1 244 ? 53.651 -27.668 -2.246 1.00 14.51 ? 264 PHE B CE1 1 ATOM 3988 C CE2 . PHE B 1 244 ? 53.959 -27.217 -4.587 1.00 15.24 ? 264 PHE B CE2 1 ATOM 3989 C CZ . PHE B 1 244 ? 54.130 -26.839 -3.258 1.00 15.00 ? 264 PHE B CZ 1 ATOM 3990 N N . GLU B 1 245 ? 49.667 -29.659 -2.084 1.00 13.52 ? 265 GLU B N 1 ATOM 3991 C CA . GLU B 1 245 ? 49.164 -29.650 -0.681 1.00 14.57 ? 265 GLU B CA 1 ATOM 3992 C C . GLU B 1 245 ? 47.986 -30.594 -0.512 1.00 14.26 ? 265 GLU B C 1 ATOM 3993 O O . GLU B 1 245 ? 47.957 -31.388 0.424 1.00 11.93 ? 265 GLU B O 1 ATOM 3994 C CB . GLU B 1 245 ? 48.884 -28.236 -0.137 1.00 14.26 ? 265 GLU B CB 1 ATOM 3995 C CG . GLU B 1 245 ? 50.215 -27.510 0.137 1.00 15.28 ? 265 GLU B CG 1 ATOM 3996 C CD . GLU B 1 245 ? 50.159 -26.079 0.600 1.00 16.16 ? 265 GLU B CD 1 ATOM 3997 O OE1 . GLU B 1 245 ? 51.254 -25.592 0.937 1.00 16.89 ? 265 GLU B OE1 1 ATOM 3998 O OE2 . GLU B 1 245 ? 49.070 -25.439 0.659 1.00 18.93 ? 265 GLU B OE2 1 ATOM 3999 N N . GLU B 1 246 ? 47.045 -30.551 -1.460 1.00 14.70 ? 266 GLU B N 1 ATOM 4000 C CA . GLU B 1 246 ? 45.934 -31.492 -1.401 1.00 15.91 ? 266 GLU B CA 1 ATOM 4001 C C . GLU B 1 246 ? 46.363 -32.932 -1.607 1.00 14.00 ? 266 GLU B C 1 ATOM 4002 O O . GLU B 1 246 ? 45.833 -33.840 -0.973 1.00 12.76 ? 266 GLU B O 1 ATOM 4003 C CB . GLU B 1 246 ? 44.844 -31.135 -2.413 1.00 18.30 ? 266 GLU B CB 1 ATOM 4004 C CG . GLU B 1 246 ? 43.558 -31.872 -2.123 1.00 20.18 ? 266 GLU B CG 1 ATOM 4005 C CD . GLU B 1 246 ? 42.363 -31.398 -2.977 1.00 26.18 ? 266 GLU B CD 1 ATOM 4006 O OE1 . GLU B 1 246 ? 41.780 -32.232 -3.665 1.00 25.83 ? 266 GLU B OE1 1 ATOM 4007 O OE2 . GLU B 1 246 ? 42.013 -30.181 -2.948 1.00 33.07 ? 266 GLU B OE2 1 ATOM 4008 N N . LEU B 1 247 ? 47.300 -33.157 -2.532 1.00 13.01 ? 267 LEU B N 1 ATOM 4009 C CA . LEU B 1 247 ? 47.798 -34.541 -2.760 1.00 13.58 ? 267 LEU B CA 1 ATOM 4010 C C . LEU B 1 247 ? 48.545 -35.142 -1.555 1.00 12.73 ? 267 LEU B C 1 ATOM 4011 O O . LEU B 1 247 ? 48.423 -36.346 -1.295 1.00 11.81 ? 267 LEU B O 1 ATOM 4012 C CB . LEU B 1 247 ? 48.672 -34.594 -4.018 1.00 14.05 ? 267 LEU B CB 1 ATOM 4013 C CG . LEU B 1 247 ? 47.831 -34.456 -5.281 1.00 14.64 ? 267 LEU B CG 1 ATOM 4014 C CD1 . LEU B 1 247 ? 48.756 -34.220 -6.472 1.00 16.23 ? 267 LEU B CD1 1 ATOM 4015 C CD2 . LEU B 1 247 ? 47.008 -35.697 -5.537 1.00 15.84 ? 267 LEU B CD2 1 ATOM 4016 N N . ILE B 1 248 ? 49.349 -34.306 -0.861 1.00 12.90 ? 268 ILE B N 1 ATOM 4017 C CA . ILE B 1 248 ? 50.052 -34.753 0.321 1.00 13.18 ? 268 ILE B CA 1 ATOM 4018 C C . ILE B 1 248 ? 49.013 -35.083 1.400 1.00 13.80 ? 268 ILE B C 1 ATOM 4019 O O . ILE B 1 248 ? 49.129 -36.081 2.067 1.00 14.08 ? 268 ILE B O 1 ATOM 4020 C CB . ILE B 1 248 ? 51.106 -33.708 0.778 1.00 14.22 ? 268 ILE B CB 1 ATOM 4021 C CG1 . ILE B 1 248 ? 52.289 -33.715 -0.203 1.00 15.89 ? 268 ILE B CG1 1 ATOM 4022 C CG2 . ILE B 1 248 ? 51.579 -33.952 2.200 1.00 12.69 ? 268 ILE B CG2 1 ATOM 4023 C CD1 . ILE B 1 248 ? 53.169 -32.492 -0.083 1.00 16.62 ? 268 ILE B CD1 1 ATOM 4024 N N . ALA B 1 249 ? 47.983 -34.237 1.510 1.00 14.30 ? 269 ALA B N 1 ATOM 4025 C CA . ALA B 1 249 ? 46.925 -34.485 2.477 1.00 13.72 ? 269 ALA B CA 1 ATOM 4026 C C . ALA B 1 249 ? 46.223 -35.796 2.211 1.00 14.61 ? 269 ALA B C 1 ATOM 4027 O O . ALA B 1 249 ? 45.985 -36.595 3.133 1.00 13.31 ? 269 ALA B O 1 ATOM 4028 C CB . ALA B 1 249 ? 45.928 -33.336 2.462 1.00 13.81 ? 269 ALA B CB 1 ATOM 4029 N N . LYS B 1 250 ? 45.845 -36.006 0.943 1.00 14.77 ? 270 LYS B N 1 ATOM 4030 C CA . LYS B 1 250 ? 45.226 -37.273 0.523 1.00 15.69 ? 270 LYS B CA 1 ATOM 4031 C C . LYS B 1 250 ? 46.101 -38.454 0.815 1.00 13.70 ? 270 LYS B C 1 ATOM 4032 O O . LYS B 1 250 ? 45.628 -39.507 1.221 1.00 13.79 ? 270 LYS B O 1 ATOM 4033 C CB . LYS B 1 250 ? 44.997 -37.310 -1.028 1.00 18.16 ? 270 LYS B CB 1 ATOM 4034 C CG . LYS B 1 250 ? 43.807 -36.545 -1.436 1.00 22.04 ? 270 LYS B CG 1 ATOM 4035 C CD . LYS B 1 250 ? 43.734 -36.533 -2.962 1.00 23.12 ? 270 LYS B CD 1 ATOM 4036 C CE . LYS B 1 250 ? 42.250 -36.576 -3.331 1.00 23.71 ? 270 LYS B CE 1 ATOM 4037 N NZ . LYS B 1 250 ? 42.078 -36.378 -4.766 1.00 26.11 ? 270 LYS B NZ 1 ATOM 4038 N N . ALA B 1 251 ? 47.375 -38.317 0.475 1.00 13.26 ? 271 ALA B N 1 ATOM 4039 C CA . ALA B 1 251 ? 48.289 -39.411 0.684 1.00 14.01 ? 271 ALA B CA 1 ATOM 4040 C C . ALA B 1 251 ? 48.287 -39.851 2.177 1.00 14.74 ? 271 ALA B C 1 ATOM 4041 O O . ALA B 1 251 ? 48.251 -41.037 2.482 1.00 15.01 ? 271 ALA B O 1 ATOM 4042 C CB . ALA B 1 251 ? 49.696 -39.038 0.230 1.00 12.98 ? 271 ALA B CB 1 ATOM 4043 N N . GLY B 1 252 ? 48.416 -38.876 3.056 1.00 14.24 ? 272 GLY B N 1 ATOM 4044 C CA . GLY B 1 252 ? 48.392 -39.160 4.520 1.00 15.59 ? 272 GLY B CA 1 ATOM 4045 C C . GLY B 1 252 ? 47.108 -39.819 5.003 1.00 15.36 ? 272 GLY B C 1 ATOM 4046 O O . GLY B 1 252 ? 47.123 -40.803 5.726 1.00 14.99 ? 272 GLY B O 1 ATOM 4047 N N . TYR B 1 253 ? 45.989 -39.294 4.495 1.00 16.20 ? 273 TYR B N 1 ATOM 4048 C CA . TYR B 1 253 ? 44.660 -39.794 4.880 1.00 16.55 ? 273 TYR B CA 1 ATOM 4049 C C . TYR B 1 253 ? 44.447 -41.207 4.356 1.00 16.20 ? 273 TYR B C 1 ATOM 4050 O O . TYR B 1 253 ? 43.981 -42.088 5.089 1.00 16.27 ? 273 TYR B O 1 ATOM 4051 C CB . TYR B 1 253 ? 43.598 -38.832 4.353 1.00 17.27 ? 273 TYR B CB 1 ATOM 4052 C CG . TYR B 1 253 ? 42.217 -38.983 4.914 1.00 16.92 ? 273 TYR B CG 1 ATOM 4053 C CD1 . TYR B 1 253 ? 41.903 -38.495 6.198 1.00 18.62 ? 273 TYR B CD1 1 ATOM 4054 C CD2 . TYR B 1 253 ? 41.216 -39.553 4.150 1.00 17.48 ? 273 TYR B CD2 1 ATOM 4055 C CE1 . TYR B 1 253 ? 40.623 -38.620 6.707 1.00 19.01 ? 273 TYR B CE1 1 ATOM 4056 C CE2 . TYR B 1 253 ? 39.932 -39.688 4.641 1.00 18.45 ? 273 TYR B CE2 1 ATOM 4057 C CZ . TYR B 1 253 ? 39.646 -39.220 5.924 1.00 21.02 ? 273 TYR B CZ 1 ATOM 4058 O OH . TYR B 1 253 ? 38.390 -39.333 6.422 1.00 20.96 ? 273 TYR B OH 1 ATOM 4059 N N . ARG B 1 254 ? 44.876 -41.438 3.112 1.00 15.04 ? 274 ARG B N 1 ATOM 4060 C CA . ARG B 1 254 ? 44.783 -42.769 2.534 1.00 15.68 ? 274 ARG B CA 1 ATOM 4061 C C . ARG B 1 254 ? 45.714 -43.788 3.163 1.00 15.59 ? 274 ARG B C 1 ATOM 4062 O O . ARG B 1 254 ? 45.341 -44.961 3.359 1.00 15.57 ? 274 ARG B O 1 ATOM 4063 C CB . ARG B 1 254 ? 44.992 -42.729 1.006 1.00 14.33 ? 274 ARG B CB 1 ATOM 4064 C CG . ARG B 1 254 ? 43.770 -42.194 0.274 1.00 14.62 ? 274 ARG B CG 1 ATOM 4065 C CD . ARG B 1 254 ? 44.137 -41.562 -1.089 1.00 14.38 ? 274 ARG B CD 1 ATOM 4066 N NE . ARG B 1 254 ? 42.957 -41.277 -1.867 1.00 14.67 ? 274 ARG B NE 1 ATOM 4067 C CZ . ARG B 1 254 ? 42.926 -40.657 -3.061 1.00 15.03 ? 274 ARG B CZ 1 ATOM 4068 N NH1 . ARG B 1 254 ? 44.047 -40.328 -3.717 1.00 14.23 ? 274 ARG B NH1 1 ATOM 4069 N NH2 . ARG B 1 254 ? 41.764 -40.442 -3.645 1.00 14.94 ? 274 ARG B NH2 1 ATOM 4070 N N . LEU B 1 255 ? 46.954 -43.353 3.413 1.00 15.30 ? 275 LEU B N 1 ATOM 4071 C CA . LEU B 1 255 ? 47.898 -44.176 4.126 1.00 15.08 ? 275 LEU B CA 1 ATOM 4072 C C . LEU B 1 255 ? 47.273 -44.643 5.497 1.00 15.16 ? 275 LEU B C 1 ATOM 4073 O O . LEU B 1 255 ? 47.298 -45.841 5.818 1.00 14.66 ? 275 LEU B O 1 ATOM 4074 C CB . LEU B 1 255 ? 49.233 -43.459 4.318 1.00 14.77 ? 275 LEU B CB 1 ATOM 4075 C CG . LEU B 1 255 ? 50.256 -44.140 5.246 1.00 15.10 ? 275 LEU B CG 1 ATOM 4076 C CD1 . LEU B 1 255 ? 50.630 -45.530 4.765 1.00 15.74 ? 275 LEU B CD1 1 ATOM 4077 C CD2 . LEU B 1 255 ? 51.519 -43.264 5.333 1.00 15.10 ? 275 LEU B CD2 1 ATOM 4078 N N . ALA B 1 256 ? 46.697 -43.705 6.231 1.00 14.20 ? 276 ALA B N 1 ATOM 4079 C CA . ALA B 1 256 ? 46.051 -44.047 7.550 1.00 15.33 ? 276 ALA B CA 1 ATOM 4080 C C . ALA B 1 256 ? 44.913 -45.088 7.340 1.00 16.76 ? 276 ALA B C 1 ATOM 4081 O O . ALA B 1 256 ? 44.830 -46.092 8.047 1.00 16.37 ? 276 ALA B O 1 ATOM 4082 C CB . ALA B 1 256 ? 45.505 -42.822 8.211 1.00 14.06 ? 276 ALA B CB 1 ATOM 4083 N N . ALA B 1 257 ? 44.111 -44.895 6.291 1.00 16.14 ? 277 ALA B N 1 ATOM 4084 C CA . ALA B 1 257 ? 43.012 -45.850 6.051 1.00 15.52 ? 277 ALA B CA 1 ATOM 4085 C C . ALA B 1 257 ? 43.539 -47.207 5.730 1.00 15.87 ? 277 ALA B C 1 ATOM 4086 O O . ALA B 1 257 ? 43.005 -48.253 6.194 1.00 17.73 ? 277 ALA B O 1 ATOM 4087 C CB . ALA B 1 257 ? 42.111 -45.321 4.945 1.00 17.27 ? 277 ALA B CB 1 ATOM 4088 N N . TRP B 1 258 ? 44.599 -47.242 4.915 1.00 15.11 ? 278 TRP B N 1 ATOM 4089 C CA . TRP B 1 258 ? 45.178 -48.500 4.511 1.00 14.15 ? 278 TRP B CA 1 ATOM 4090 C C . TRP B 1 258 ? 45.812 -49.237 5.675 1.00 15.48 ? 278 TRP B C 1 ATOM 4091 O O . TRP B 1 258 ? 45.656 -50.450 5.801 1.00 14.88 ? 278 TRP B O 1 ATOM 4092 C CB . TRP B 1 258 ? 46.187 -48.277 3.406 1.00 14.38 ? 278 TRP B CB 1 ATOM 4093 C CG . TRP B 1 258 ? 46.574 -49.468 2.572 1.00 15.40 ? 278 TRP B CG 1 ATOM 4094 C CD1 . TRP B 1 258 ? 47.831 -49.986 2.448 1.00 15.39 ? 278 TRP B CD1 1 ATOM 4095 C CD2 . TRP B 1 258 ? 45.737 -50.229 1.673 1.00 15.47 ? 278 TRP B CD2 1 ATOM 4096 N NE1 . TRP B 1 258 ? 47.828 -51.019 1.541 1.00 15.93 ? 278 TRP B NE1 1 ATOM 4097 C CE2 . TRP B 1 258 ? 46.555 -51.187 1.059 1.00 15.54 ? 278 TRP B CE2 1 ATOM 4098 C CE3 . TRP B 1 258 ? 44.356 -50.228 1.385 1.00 16.22 ? 278 TRP B CE3 1 ATOM 4099 C CZ2 . TRP B 1 258 ? 46.053 -52.119 0.137 1.00 17.08 ? 278 TRP B CZ2 1 ATOM 4100 C CZ3 . TRP B 1 258 ? 43.853 -51.156 0.488 1.00 15.62 ? 278 TRP B CZ3 1 ATOM 4101 C CH2 . TRP B 1 258 ? 44.689 -52.080 -0.145 1.00 16.10 ? 278 TRP B CH2 1 ATOM 4102 N N . LEU B 1 259 ? 46.559 -48.501 6.500 1.00 17.49 ? 279 LEU B N 1 ATOM 4103 C CA . LEU B 1 259 ? 47.143 -49.054 7.713 1.00 17.59 ? 279 LEU B CA 1 ATOM 4104 C C . LEU B 1 259 ? 46.046 -49.597 8.669 1.00 18.55 ? 279 LEU B C 1 ATOM 4105 O O . LEU B 1 259 ? 46.197 -50.698 9.183 1.00 18.19 ? 279 LEU B O 1 ATOM 4106 C CB . LEU B 1 259 ? 48.020 -48.047 8.433 1.00 16.97 ? 279 LEU B CB 1 ATOM 4107 C CG . LEU B 1 259 ? 49.321 -47.654 7.678 1.00 18.97 ? 279 LEU B CG 1 ATOM 4108 C CD1 . LEU B 1 259 ? 50.093 -46.564 8.450 1.00 18.72 ? 279 LEU B CD1 1 ATOM 4109 C CD2 . LEU B 1 259 ? 50.201 -48.835 7.357 1.00 17.80 ? 279 LEU B CD2 1 ATOM 4110 N N . ASP B 1 260 ? 44.964 -48.851 8.855 1.00 18.94 ? 280 ASP B N 1 ATOM 4111 C CA . ASP B 1 260 ? 43.815 -49.366 9.652 1.00 20.99 ? 280 ASP B CA 1 ATOM 4112 C C . ASP B 1 260 ? 43.301 -50.696 9.141 1.00 20.50 ? 280 ASP B C 1 ATOM 4113 O O . ASP B 1 260 ? 43.157 -51.674 9.912 1.00 20.68 ? 280 ASP B O 1 ATOM 4114 C CB . ASP B 1 260 ? 42.642 -48.385 9.696 1.00 21.20 ? 280 ASP B CB 1 ATOM 4115 C CG . ASP B 1 260 ? 42.869 -47.218 10.626 1.00 21.95 ? 280 ASP B CG 1 ATOM 4116 O OD1 . ASP B 1 260 ? 43.745 -47.266 11.531 1.00 22.38 ? 280 ASP B OD1 1 ATOM 4117 O OD2 . ASP B 1 260 ? 42.184 -46.196 10.403 1.00 21.04 ? 280 ASP B OD2 1 ATOM 4118 N N . LEU B 1 261 ? 43.178 -50.803 7.826 1.00 20.18 ? 281 LEU B N 1 ATOM 4119 C CA . LEU B 1 261 ? 42.778 -52.101 7.237 1.00 20.75 ? 281 LEU B CA 1 ATOM 4120 C C . LEU B 1 261 ? 43.776 -53.204 7.457 1.00 21.74 ? 281 LEU B C 1 ATOM 4121 O O . LEU B 1 261 ? 43.389 -54.348 7.765 1.00 22.19 ? 281 LEU B O 1 ATOM 4122 C CB . LEU B 1 261 ? 42.478 -52.003 5.732 1.00 19.27 ? 281 LEU B CB 1 ATOM 4123 C CG . LEU B 1 261 ? 41.206 -51.204 5.443 1.00 21.67 ? 281 LEU B CG 1 ATOM 4124 C CD1 . LEU B 1 261 ? 41.170 -50.648 4.003 1.00 20.89 ? 281 LEU B CD1 1 ATOM 4125 C CD2 . LEU B 1 261 ? 39.952 -52.032 5.745 1.00 22.35 ? 281 LEU B CD2 1 ATOM 4126 N N . ILE B 1 262 ? 45.066 -52.896 7.281 1.00 21.88 ? 282 ILE B N 1 ATOM 4127 C CA . ILE B 1 262 ? 46.112 -53.921 7.443 1.00 21.28 ? 282 ILE B CA 1 ATOM 4128 C C . ILE B 1 262 ? 46.130 -54.417 8.899 1.00 24.14 ? 282 ILE B C 1 ATOM 4129 O O . ILE B 1 262 ? 46.222 -55.605 9.182 1.00 23.70 ? 282 ILE B O 1 ATOM 4130 C CB . ILE B 1 262 ? 47.501 -53.401 7.067 1.00 22.02 ? 282 ILE B CB 1 ATOM 4131 C CG1 . ILE B 1 262 ? 47.566 -53.174 5.548 1.00 22.66 ? 282 ILE B CG1 1 ATOM 4132 C CG2 . ILE B 1 262 ? 48.606 -54.360 7.527 1.00 21.58 ? 282 ILE B CG2 1 ATOM 4133 C CD1 . ILE B 1 262 ? 48.782 -52.377 5.114 1.00 21.48 ? 282 ILE B CD1 1 ATOM 4134 N N . ALA B 1 263 ? 46.043 -53.470 9.796 1.00 24.07 ? 283 ALA B N 1 ATOM 4135 C CA . ALA B 1 263 ? 46.142 -53.761 11.219 1.00 28.27 ? 283 ALA B CA 1 ATOM 4136 C C . ALA B 1 263 ? 44.908 -54.542 11.749 1.00 31.18 ? 283 ALA B C 1 ATOM 4137 O O . ALA B 1 263 ? 44.979 -55.167 12.786 1.00 31.66 ? 283 ALA B O 1 ATOM 4138 C CB . ALA B 1 263 ? 46.292 -52.457 11.991 1.00 26.16 ? 283 ALA B CB 1 ATOM 4139 N N . SER B 1 264 ? 43.789 -54.499 11.050 1.00 33.43 ? 284 SER B N 1 ATOM 4140 C CA . SER B 1 264 ? 42.587 -55.090 11.583 1.00 42.00 ? 284 SER B CA 1 ATOM 4141 C C . SER B 1 264 ? 42.234 -56.493 11.063 1.00 47.23 ? 284 SER B C 1 ATOM 4142 O O . SER B 1 264 ? 41.175 -56.969 11.377 1.00 57.34 ? 284 SER B O 1 ATOM 4143 C CB . SER B 1 264 ? 41.437 -54.100 11.380 1.00 43.06 ? 284 SER B CB 1 ATOM 4144 O OG . SER B 1 264 ? 41.081 -54.100 10.027 1.00 44.59 ? 284 SER B OG 1 ATOM 4145 N N . GLN B 1 265 ? 43.110 -57.178 10.328 1.00 58.91 ? 285 GLN B N 1 ATOM 4146 C CA . GLN B 1 265 ? 42.732 -58.468 9.690 1.00 68.69 ? 285 GLN B CA 1 ATOM 4147 C C . GLN B 1 265 ? 42.763 -59.610 10.671 1.00 66.22 ? 285 GLN B C 1 ATOM 4148 O O . GLN B 1 265 ? 43.813 -59.814 11.257 1.00 72.82 ? 285 GLN B O 1 ATOM 4149 C CB . GLN B 1 265 ? 43.669 -58.805 8.510 1.00 73.52 ? 285 GLN B CB 1 ATOM 4150 C CG . GLN B 1 265 ? 42.927 -59.395 7.310 1.00 75.81 ? 285 GLN B CG 1 ATOM 4151 C CD . GLN B 1 265 ? 41.849 -58.464 6.732 1.00 75.64 ? 285 GLN B CD 1 ATOM 4152 O OE1 . GLN B 1 265 ? 40.916 -58.931 6.072 1.00 81.37 ? 285 GLN B OE1 1 ATOM 4153 N NE2 . GLN B 1 265 ? 41.964 -57.153 6.976 1.00 68.32 ? 285 GLN B NE2 1 HETATM 4154 ZN ZN . ZN C 2 . ? 31.230 -53.359 -13.007 1.00 15.50 2 401 ZN A ZN 1 HETATM 4155 ZN ZN . ZN D 2 . ? 31.339 -49.715 -13.072 1.00 14.39 2 402 ZN A ZN 1 HETATM 4156 ZN ZN . ZN E 2 . ? 28.498 -53.246 -9.703 1.00 18.49 2 403 ZN A ZN 1 HETATM 4157 C C1 . NAG F 3 . ? 30.345 -36.059 -21.648 1.00 36.23 ? 501 NAG A C1 1 HETATM 4158 C C2 . NAG F 3 . ? 29.646 -35.432 -20.446 1.00 39.58 ? 501 NAG A C2 1 HETATM 4159 C C3 . NAG F 3 . ? 30.449 -34.239 -19.924 1.00 40.60 ? 501 NAG A C3 1 HETATM 4160 C C4 . NAG F 3 . ? 31.883 -34.671 -19.713 1.00 39.06 ? 501 NAG A C4 1 HETATM 4161 C C5 . NAG F 3 . ? 32.504 -35.345 -20.954 1.00 36.98 ? 501 NAG A C5 1 HETATM 4162 C C6 . NAG F 3 . ? 33.935 -35.897 -20.672 1.00 34.04 ? 501 NAG A C6 1 HETATM 4163 C C7 . NAG F 3 . ? 27.174 -35.594 -20.605 1.00 44.77 ? 501 NAG A C7 1 HETATM 4164 C C8 . NAG F 3 . ? 25.924 -34.886 -21.125 1.00 42.59 ? 501 NAG A C8 1 HETATM 4165 N N2 . NAG F 3 . ? 28.326 -34.948 -20.850 1.00 42.28 ? 501 NAG A N2 1 HETATM 4166 O O3 . NAG F 3 . ? 29.908 -33.723 -18.679 1.00 39.67 ? 501 NAG A O3 1 HETATM 4167 O O4 . NAG F 3 . ? 32.606 -33.497 -19.389 1.00 42.24 ? 501 NAG A O4 1 HETATM 4168 O O5 . NAG F 3 . ? 31.682 -36.430 -21.370 1.00 33.89 ? 501 NAG A O5 1 HETATM 4169 O O6 . NAG F 3 . ? 33.960 -36.854 -19.602 1.00 25.98 ? 501 NAG A O6 1 HETATM 4170 O O7 . NAG F 3 . ? 27.155 -36.672 -20.011 1.00 38.14 ? 501 NAG A O7 1 HETATM 4171 C C1 . NAG G 3 . ? 16.890 -59.659 8.238 1.00 43.70 ? 502 NAG A C1 1 HETATM 4172 C C2 . NAG G 3 . ? 15.508 -58.921 8.261 1.00 42.76 ? 502 NAG A C2 1 HETATM 4173 C C3 . NAG G 3 . ? 15.438 -57.762 9.283 1.00 48.83 ? 502 NAG A C3 1 HETATM 4174 C C4 . NAG G 3 . ? 16.046 -58.184 10.644 1.00 51.01 ? 502 NAG A C4 1 HETATM 4175 C C5 . NAG G 3 . ? 17.349 -59.014 10.491 1.00 51.08 ? 502 NAG A C5 1 HETATM 4176 C C6 . NAG G 3 . ? 17.848 -59.492 11.852 1.00 50.33 ? 502 NAG A C6 1 HETATM 4177 C C7 . NAG G 3 . ? 14.242 -59.109 6.145 1.00 37.06 ? 502 NAG A C7 1 HETATM 4178 C C8 . NAG G 3 . ? 13.798 -58.537 4.808 1.00 37.14 ? 502 NAG A C8 1 HETATM 4179 N N2 . NAG G 3 . ? 15.061 -58.401 6.962 1.00 38.02 ? 502 NAG A N2 1 HETATM 4180 O O3 . NAG G 3 . ? 14.108 -57.200 9.468 1.00 38.94 ? 502 NAG A O3 1 HETATM 4181 O O4 . NAG G 3 . ? 16.352 -56.936 11.310 1.00 47.62 ? 502 NAG A O4 1 HETATM 4182 O O5 . NAG G 3 . ? 17.195 -60.130 9.563 1.00 49.67 ? 502 NAG A O5 1 HETATM 4183 O O6 . NAG G 3 . ? 17.422 -60.840 12.041 1.00 56.19 ? 502 NAG A O6 1 HETATM 4184 O O7 . NAG G 3 . ? 13.862 -60.228 6.473 1.00 33.96 ? 502 NAG A O7 1 HETATM 4185 P P . PO4 H 4 . ? 31.002 -51.283 -10.719 1.00 17.07 ? 601 PO4 A P 1 HETATM 4186 O O1 . PO4 H 4 . ? 31.608 -51.958 -11.924 1.00 19.20 ? 601 PO4 A O1 1 HETATM 4187 O O2 . PO4 H 4 . ? 30.483 -49.912 -11.174 1.00 15.71 ? 601 PO4 A O2 1 HETATM 4188 O O3 . PO4 H 4 . ? 29.919 -52.087 -10.083 1.00 26.94 ? 601 PO4 A O3 1 HETATM 4189 O O4 . PO4 H 4 . ? 31.925 -50.943 -9.571 1.00 18.10 ? 601 PO4 A O4 1 HETATM 4190 N N1 . DCZ I 5 . ? 25.920 -49.247 -7.968 1.00 23.21 ? 701 DCZ A N1 1 HETATM 4191 C C2 . DCZ I 5 . ? 24.796 -49.543 -8.755 1.00 19.88 ? 701 DCZ A C2 1 HETATM 4192 N N3 . DCZ I 5 . ? 23.617 -48.882 -8.508 1.00 16.91 ? 701 DCZ A N3 1 HETATM 4193 C C4 . DCZ I 5 . ? 23.564 -47.941 -7.562 1.00 20.29 ? 701 DCZ A C4 1 HETATM 4194 C C5 . DCZ I 5 . ? 24.703 -47.629 -6.731 1.00 19.38 ? 701 DCZ A C5 1 HETATM 4195 C C6 . DCZ I 5 . ? 25.838 -48.311 -6.952 1.00 20.53 ? 701 DCZ A C6 1 HETATM 4196 O O2 . DCZ I 5 . ? 24.929 -50.325 -9.696 1.00 20.00 ? 701 DCZ A O2 1 HETATM 4197 N N4 . DCZ I 5 . ? 22.429 -47.285 -7.405 1.00 19.92 ? 701 DCZ A N4 1 HETATM 4198 C "C1'" . DCZ I 5 . ? 27.212 -49.886 -8.297 1.00 26.47 ? 701 DCZ A "C1'" 1 HETATM 4199 C "C2'" . DCZ I 5 . ? 28.352 -48.907 -8.596 1.00 27.43 ? 701 DCZ A "C2'" 1 HETATM 4200 C "C3'" . DCZ I 5 . ? 29.195 -48.917 -7.314 1.00 29.60 ? 701 DCZ A "C3'" 1 HETATM 4201 C "C4'" . DCZ I 5 . ? 28.958 -50.333 -6.804 1.00 30.99 ? 701 DCZ A "C4'" 1 HETATM 4202 O "O4'" . DCZ I 5 . ? 27.602 -50.648 -7.177 1.00 27.37 ? 701 DCZ A "O4'" 1 HETATM 4203 O "O3'" . DCZ I 5 . ? 30.623 -48.802 -7.454 1.00 23.30 ? 701 DCZ A "O3'" 1 HETATM 4204 C "C5'" . DCZ I 5 . ? 29.137 -50.544 -5.305 1.00 32.21 ? 701 DCZ A "C5'" 1 HETATM 4205 O "O5'" . DCZ I 5 . ? 29.199 -51.958 -5.075 1.00 29.55 ? 701 DCZ A "O5'" 1 HETATM 4206 N N1 . DCZ J 5 . ? 40.249 -62.102 -3.396 1.00 69.20 ? 702 DCZ A N1 1 HETATM 4207 C C2 . DCZ J 5 . ? 39.261 -62.608 -4.255 1.00 62.30 ? 702 DCZ A C2 1 HETATM 4208 N N3 . DCZ J 5 . ? 38.780 -61.795 -5.245 1.00 50.20 ? 702 DCZ A N3 1 HETATM 4209 C C4 . DCZ J 5 . ? 39.285 -60.564 -5.440 1.00 49.73 ? 702 DCZ A C4 1 HETATM 4210 C C5 . DCZ J 5 . ? 40.316 -60.048 -4.605 1.00 51.62 ? 702 DCZ A C5 1 HETATM 4211 C C6 . DCZ J 5 . ? 40.765 -60.837 -3.608 1.00 62.82 ? 702 DCZ A C6 1 HETATM 4212 O O2 . DCZ J 5 . ? 38.932 -63.796 -4.158 1.00 54.34 ? 702 DCZ A O2 1 HETATM 4213 N N4 . DCZ J 5 . ? 38.834 -59.850 -6.480 1.00 41.84 ? 702 DCZ A N4 1 HETATM 4214 C "C1'" . DCZ J 5 . ? 40.671 -62.955 -2.237 1.00 79.21 ? 702 DCZ A "C1'" 1 HETATM 4215 C "C2'" . DCZ J 5 . ? 41.732 -63.995 -2.576 1.00 84.11 ? 702 DCZ A "C2'" 1 HETATM 4216 C "C3'" . DCZ J 5 . ? 43.033 -63.264 -2.262 1.00 87.60 ? 702 DCZ A "C3'" 1 HETATM 4217 C "C4'" . DCZ J 5 . ? 42.645 -62.392 -1.065 1.00 86.06 ? 702 DCZ A "C4'" 1 HETATM 4218 O "O4'" . DCZ J 5 . ? 41.230 -62.110 -1.227 1.00 86.67 ? 702 DCZ A "O4'" 1 HETATM 4219 O "O3'" . DCZ J 5 . ? 44.065 -64.188 -1.912 1.00 81.92 ? 702 DCZ A "O3'" 1 HETATM 4220 C "C5'" . DCZ J 5 . ? 43.432 -61.093 -0.940 1.00 79.66 ? 702 DCZ A "C5'" 1 HETATM 4221 O "O5'" . DCZ J 5 . ? 43.632 -60.693 0.417 1.00 76.25 ? 702 DCZ A "O5'" 1 HETATM 4222 ZN ZN . ZN K 2 . ? 59.482 -39.543 -2.746 1.00 13.77 2 401 ZN B ZN 1 HETATM 4223 ZN ZN . ZN L 2 . ? 60.674 -42.771 -3.354 1.00 14.68 2 402 ZN B ZN 1 HETATM 4224 ZN ZN . ZN M 2 . ? 60.656 -38.401 -6.888 1.00 15.11 2 403 ZN B ZN 1 HETATM 4225 C C1 . NAG N 3 . ? 58.275 -58.943 -2.386 1.00 47.77 ? 501 NAG B C1 1 HETATM 4226 C C2 . NAG N 3 . ? 59.019 -59.014 -3.739 1.00 53.65 ? 501 NAG B C2 1 HETATM 4227 C C3 . NAG N 3 . ? 60.396 -59.667 -3.595 1.00 54.66 ? 501 NAG B C3 1 HETATM 4228 C C4 . NAG N 3 . ? 61.203 -58.971 -2.506 1.00 52.18 ? 501 NAG B C4 1 HETATM 4229 C C5 . NAG N 3 . ? 60.432 -58.996 -1.165 1.00 49.78 ? 501 NAG B C5 1 HETATM 4230 C C6 . NAG N 3 . ? 61.162 -58.237 -0.041 1.00 42.46 ? 501 NAG B C6 1 HETATM 4231 C C7 . NAG N 3 . ? 57.617 -59.210 -5.789 1.00 57.82 ? 501 NAG B C7 1 HETATM 4232 C C8 . NAG N 3 . ? 56.913 -60.204 -6.665 1.00 57.60 ? 501 NAG B C8 1 HETATM 4233 N N2 . NAG N 3 . ? 58.245 -59.766 -4.736 1.00 56.71 ? 501 NAG B N2 1 HETATM 4234 O O3 . NAG N 3 . ? 61.111 -59.547 -4.832 1.00 56.28 ? 501 NAG B O3 1 HETATM 4235 O O4 . NAG N 3 . ? 62.489 -59.598 -2.398 1.00 51.95 ? 501 NAG B O4 1 HETATM 4236 O O5 . NAG N 3 . ? 59.120 -58.437 -1.335 1.00 46.46 ? 501 NAG B O5 1 HETATM 4237 O O6 . NAG N 3 . ? 61.671 -56.965 -0.512 1.00 31.79 ? 501 NAG B O6 1 HETATM 4238 O O7 . NAG N 3 . ? 57.594 -58.006 -6.048 1.00 51.12 ? 501 NAG B O7 1 HETATM 4239 C C1 . NAG O 3 . ? 61.267 -26.017 -24.929 1.00 32.75 ? 502 NAG B C1 1 HETATM 4240 C C2 . NAG O 3 . ? 62.455 -26.463 -25.803 1.00 34.96 ? 502 NAG B C2 1 HETATM 4241 C C3 . NAG O 3 . ? 62.260 -26.240 -27.312 1.00 39.20 ? 502 NAG B C3 1 HETATM 4242 C C4 . NAG O 3 . ? 60.921 -26.814 -27.732 1.00 39.20 ? 502 NAG B C4 1 HETATM 4243 C C5 . NAG O 3 . ? 59.788 -26.374 -26.760 1.00 36.68 ? 502 NAG B C5 1 HETATM 4244 C C6 . NAG O 3 . ? 58.505 -27.107 -27.146 1.00 34.83 ? 502 NAG B C6 1 HETATM 4245 C C7 . NAG O 3 . ? 64.759 -26.233 -25.002 1.00 39.77 ? 502 NAG B C7 1 HETATM 4246 C C8 . NAG O 3 . ? 65.841 -25.228 -24.717 1.00 43.61 ? 502 NAG B C8 1 HETATM 4247 N N2 . NAG O 3 . ? 63.630 -25.711 -25.472 1.00 37.36 ? 502 NAG B N2 1 HETATM 4248 O O3 . NAG O 3 . ? 63.321 -26.853 -28.086 1.00 38.02 ? 502 NAG B O3 1 HETATM 4249 O O4 . NAG O 3 . ? 60.702 -26.441 -29.101 1.00 42.60 ? 502 NAG B O4 1 HETATM 4250 O O5 . NAG O 3 . ? 60.094 -26.681 -25.374 1.00 30.62 ? 502 NAG B O5 1 HETATM 4251 O O6 . NAG O 3 . ? 58.584 -28.456 -26.653 1.00 33.46 ? 502 NAG B O6 1 HETATM 4252 O O7 . NAG O 3 . ? 64.906 -27.416 -24.772 1.00 43.36 ? 502 NAG B O7 1 HETATM 4253 P P . PO4 P 4 . ? 61.718 -40.499 -4.452 1.00 15.76 ? 601 PO4 B P 1 HETATM 4254 O O1 . PO4 P 4 . ? 61.641 -41.850 -5.127 1.00 14.09 ? 601 PO4 B O1 1 HETATM 4255 O O2 . PO4 P 4 . ? 61.041 -39.344 -5.124 1.00 13.54 ? 601 PO4 B O2 1 HETATM 4256 O O3 . PO4 P 4 . ? 61.032 -40.728 -3.156 1.00 14.21 ? 601 PO4 B O3 1 HETATM 4257 O O4 . PO4 P 4 . ? 63.208 -40.082 -4.311 1.00 15.36 ? 601 PO4 B O4 1 HETATM 4258 O "O5'" . GNG Q 6 . ? 66.911 -39.551 -9.897 1.00 71.16 ? 701 GNG B "O5'" 1 HETATM 4259 C "C5'" . GNG Q 6 . ? 67.894 -39.949 -10.858 1.00 63.38 ? 701 GNG B "C5'" 1 HETATM 4260 C "C4'" . GNG Q 6 . ? 67.358 -40.876 -11.932 1.00 65.53 ? 701 GNG B "C4'" 1 HETATM 4261 O "O4'" . GNG Q 6 . ? 66.511 -41.872 -11.307 1.00 67.31 ? 701 GNG B "O4'" 1 HETATM 4262 C "C1'" . GNG Q 6 . ? 65.367 -42.126 -12.126 1.00 58.49 ? 701 GNG B "C1'" 1 HETATM 4263 N N9 . GNG Q 6 . ? 64.095 -41.701 -11.363 1.00 46.04 ? 701 GNG B N9 1 HETATM 4264 C C8 . GNG Q 6 . ? 63.940 -41.116 -10.113 1.00 41.84 ? 701 GNG B C8 1 HETATM 4265 N N7 . GNG Q 6 . ? 62.652 -40.913 -9.794 1.00 31.98 ? 701 GNG B N7 1 HETATM 4266 C C5 . GNG Q 6 . ? 61.941 -41.393 -10.892 1.00 30.74 ? 701 GNG B C5 1 HETATM 4267 C C4 . GNG Q 6 . ? 62.825 -41.885 -11.855 1.00 31.77 ? 701 GNG B C4 1 HETATM 4268 N N3 . GNG Q 6 . ? 62.419 -42.395 -13.065 1.00 26.71 ? 701 GNG B N3 1 HETATM 4269 C C2 . GNG Q 6 . ? 61.076 -42.379 -13.335 1.00 24.42 ? 701 GNG B C2 1 HETATM 4270 N N1 . GNG Q 6 . ? 60.164 -41.912 -12.496 1.00 22.40 ? 701 GNG B N1 1 HETATM 4271 C C6 . GNG Q 6 . ? 60.510 -41.420 -11.241 1.00 27.22 ? 701 GNG B C6 1 HETATM 4272 O O6 . GNG Q 6 . ? 59.642 -41.079 -10.428 1.00 30.03 ? 701 GNG B O6 1 HETATM 4273 N N2 . GNG Q 6 . ? 60.718 -42.809 -14.512 1.00 23.58 ? 701 GNG B N2 1 HETATM 4274 C "C2'" . GNG Q 6 . ? 65.627 -41.408 -13.451 1.00 61.74 ? 701 GNG B "C2'" 1 HETATM 4275 C "C3'" . GNG Q 6 . ? 66.490 -40.229 -13.020 1.00 63.22 ? 701 GNG B "C3'" 1 HETATM 4276 O "O3'" . GNG Q 6 . ? 67.184 -39.639 -14.134 1.00 62.10 ? 701 GNG B "O3'" 1 HETATM 4277 O O . HOH R 7 . ? 18.870 -69.257 -31.193 0.50 14.37 ? 1001 HOH A O 1 HETATM 4278 O O . HOH R 7 . ? 21.345 -67.321 -33.384 0.50 17.85 ? 1002 HOH A O 1 HETATM 4279 O O . HOH R 7 . ? 32.992 -61.010 -0.301 0.50 24.98 ? 1003 HOH A O 1 HETATM 4280 O O . HOH R 7 . ? 17.690 -72.571 -1.505 1.00 48.02 ? 1004 HOH A O 1 HETATM 4281 O O . HOH R 7 . ? 41.624 -59.451 -12.740 1.00 29.77 ? 1005 HOH A O 1 HETATM 4282 O O . HOH R 7 . ? 28.393 -38.791 -19.970 1.00 29.39 ? 1006 HOH A O 1 HETATM 4283 O O . HOH R 7 . ? 22.520 -71.919 -29.234 1.00 49.48 ? 1007 HOH A O 1 HETATM 4284 O O . HOH R 7 . ? 35.861 -34.556 -7.046 1.00 29.69 ? 1008 HOH A O 1 HETATM 4285 O O . HOH R 7 . ? 22.049 -64.417 3.033 1.00 28.24 ? 1009 HOH A O 1 HETATM 4286 O O . HOH R 7 . ? 32.567 -40.935 -37.064 1.00 40.92 ? 1010 HOH A O 1 HETATM 4287 O O . HOH R 7 . ? 23.866 -60.925 -33.863 1.00 43.07 ? 1011 HOH A O 1 HETATM 4288 O O . HOH R 7 . ? 29.318 -72.629 -3.856 1.00 30.39 ? 1012 HOH A O 1 HETATM 4289 O O . HOH R 7 . ? 18.049 -49.067 -31.177 1.00 34.39 ? 1013 HOH A O 1 HETATM 4290 O O . HOH R 7 . ? 31.320 -75.454 -28.582 1.00 44.02 ? 1014 HOH A O 1 HETATM 4291 O O . HOH R 7 . ? 28.168 -32.975 -36.431 1.00 35.93 ? 1015 HOH A O 1 HETATM 4292 O O . HOH R 7 . ? 17.038 -62.524 -21.930 1.00 24.27 ? 1016 HOH A O 1 HETATM 4293 O O . HOH R 7 . ? 14.930 -68.251 -9.562 1.00 42.47 ? 1017 HOH A O 1 HETATM 4294 O O . HOH R 7 . ? 5.252 -61.273 -11.860 1.00 20.00 ? 1018 HOH A O 1 HETATM 4295 O O . HOH R 7 . ? 16.125 -56.164 6.222 1.00 47.96 ? 1019 HOH A O 1 HETATM 4296 O O . HOH R 7 . ? 42.660 -41.750 -18.776 1.00 11.84 ? 1020 HOH A O 1 HETATM 4297 O O . HOH R 7 . ? 35.740 -71.718 -8.199 1.00 35.37 ? 1021 HOH A O 1 HETATM 4298 O O . HOH R 7 . ? 26.796 -70.044 5.803 1.00 43.60 ? 1022 HOH A O 1 HETATM 4299 O O . HOH R 7 . ? 48.562 -49.128 -31.910 1.00 40.71 ? 1023 HOH A O 1 HETATM 4300 O O . HOH R 7 . ? 12.058 -62.042 6.943 1.00 55.97 ? 1024 HOH A O 1 HETATM 4301 O O . HOH R 7 . ? 36.281 -59.574 -9.828 1.00 19.59 ? 1025 HOH A O 1 HETATM 4302 O O . HOH R 7 . ? 41.486 -51.765 -16.248 1.00 15.07 ? 1026 HOH A O 1 HETATM 4303 O O . HOH R 7 . ? 31.380 -38.966 -4.208 1.00 31.70 ? 1027 HOH A O 1 HETATM 4304 O O . HOH R 7 . ? 40.776 -33.829 -23.279 1.00 34.84 ? 1028 HOH A O 1 HETATM 4305 O O . HOH R 7 . ? 15.277 -62.019 -33.642 1.00 25.90 ? 1029 HOH A O 1 HETATM 4306 O O . HOH R 7 . ? 33.451 -58.110 -36.652 1.00 38.90 ? 1030 HOH A O 1 HETATM 4307 O O . HOH R 7 . ? 19.765 -38.187 -23.924 1.00 20.00 ? 1031 HOH A O 1 HETATM 4308 O O . HOH R 7 . ? 39.706 -57.917 -8.037 1.00 38.26 ? 1032 HOH A O 1 HETATM 4309 O O . HOH R 7 . ? 36.751 -33.463 -14.168 1.00 28.92 ? 1033 HOH A O 1 HETATM 4310 O O . HOH R 7 . ? 30.804 -73.564 -10.186 1.00 37.82 ? 1034 HOH A O 1 HETATM 4311 O O . HOH R 7 . ? 27.020 -36.599 -12.792 1.00 20.00 ? 1035 HOH A O 1 HETATM 4312 O O . HOH R 7 . ? 14.537 -62.995 -17.207 1.00 30.32 ? 1036 HOH A O 1 HETATM 4313 O O . HOH R 7 . ? 39.922 -30.904 -5.234 1.00 38.13 ? 1037 HOH A O 1 HETATM 4314 O O . HOH R 7 . ? 31.232 -39.830 -41.610 1.00 21.62 ? 1038 HOH A O 1 HETATM 4315 O O . HOH R 7 . ? 19.213 -58.820 3.779 1.00 21.62 ? 1039 HOH A O 1 HETATM 4316 O O . HOH R 7 . ? 24.972 -37.817 -19.054 1.00 39.03 ? 1040 HOH A O 1 HETATM 4317 O O . HOH R 7 . ? 21.721 -69.823 -20.678 1.00 41.92 ? 1041 HOH A O 1 HETATM 4318 O O . HOH R 7 . ? 13.133 -54.842 -18.412 1.00 18.84 ? 1042 HOH A O 1 HETATM 4319 O O . HOH R 7 . ? 31.767 -57.378 0.258 1.00 36.02 ? 1043 HOH A O 1 HETATM 4320 O O . HOH R 7 . ? 7.478 -54.975 -17.773 0.50 22.45 ? 1044 HOH A O 1 HETATM 4321 O O . HOH R 7 . ? 29.337 -46.021 -9.705 1.00 15.69 ? 1045 HOH A O 1 HETATM 4322 O O . HOH R 7 . ? 39.449 -35.322 -4.580 0.50 22.44 ? 1046 HOH A O 1 HETATM 4323 O O . HOH R 7 . ? 26.187 -74.107 -5.249 1.00 38.03 ? 1047 HOH A O 1 HETATM 4324 O O . HOH R 7 . ? 31.428 -47.313 -4.939 1.00 33.27 ? 1048 HOH A O 1 HETATM 4325 O O . HOH R 7 . ? 20.202 -41.896 -28.996 1.00 16.79 ? 1049 HOH A O 1 HETATM 4326 O O . HOH R 7 . ? 45.959 -66.783 -12.206 1.00 43.85 ? 1050 HOH A O 1 HETATM 4327 O O . HOH R 7 . ? 30.088 -56.386 -36.150 1.00 30.11 ? 1051 HOH A O 1 HETATM 4328 O O . HOH R 7 . ? 18.596 -69.832 -13.980 1.00 32.57 ? 1052 HOH A O 1 HETATM 4329 O O . HOH R 7 . ? 33.623 -43.582 -14.177 1.00 12.62 ? 1053 HOH A O 1 HETATM 4330 O O . HOH R 7 . ? 24.227 -69.693 -19.728 1.00 26.71 ? 1054 HOH A O 1 HETATM 4331 O O . HOH R 7 . ? 32.653 -73.473 -24.197 1.00 27.99 ? 1055 HOH A O 1 HETATM 4332 O O . HOH R 7 . ? 37.084 -48.638 -18.262 1.00 9.66 ? 1056 HOH A O 1 HETATM 4333 O O . HOH R 7 . ? 14.663 -61.924 -20.481 1.00 35.88 ? 1057 HOH A O 1 HETATM 4334 O O . HOH R 7 . ? 40.863 -49.567 -9.605 1.00 16.70 ? 1058 HOH A O 1 HETATM 4335 O O . HOH R 7 . ? 29.235 -38.145 -8.462 1.00 27.46 ? 1059 HOH A O 1 HETATM 4336 O O . HOH R 7 . ? 15.808 -38.721 -16.415 1.00 26.65 ? 1060 HOH A O 1 HETATM 4337 O O . HOH R 7 . ? 26.353 -35.918 -16.703 1.00 39.99 ? 1061 HOH A O 1 HETATM 4338 O O . HOH R 7 . ? 33.854 -66.382 -5.013 1.00 25.86 ? 1062 HOH A O 1 HETATM 4339 O O . HOH R 7 . ? 41.066 -58.204 -31.085 1.00 20.87 ? 1063 HOH A O 1 HETATM 4340 O O . HOH R 7 . ? 39.215 -41.863 -3.454 1.00 19.13 ? 1064 HOH A O 1 HETATM 4341 O O . HOH R 7 . ? 12.468 -50.568 -7.677 1.00 23.41 ? 1065 HOH A O 1 HETATM 4342 O O . HOH R 7 . ? 18.157 -54.477 3.236 1.00 42.20 ? 1066 HOH A O 1 HETATM 4343 O O . HOH R 7 . ? 26.251 -72.192 -16.809 1.00 33.27 ? 1067 HOH A O 1 HETATM 4344 O O . HOH R 7 . ? 30.872 -74.291 -22.134 1.00 35.09 ? 1068 HOH A O 1 HETATM 4345 O O . HOH R 7 . ? 22.194 -45.057 -5.895 1.00 38.53 ? 1069 HOH A O 1 HETATM 4346 O O . HOH R 7 . ? 22.897 -49.873 -16.478 1.00 10.80 ? 1070 HOH A O 1 HETATM 4347 O O . HOH R 7 . ? 15.415 -55.658 -24.397 1.00 17.61 ? 1071 HOH A O 1 HETATM 4348 O O . HOH R 7 . ? 40.228 -62.415 -26.394 1.00 26.47 ? 1072 HOH A O 1 HETATM 4349 O O . HOH R 7 . ? 24.014 -38.032 -23.269 1.00 24.50 ? 1073 HOH A O 1 HETATM 4350 O O . HOH R 7 . ? 43.223 -70.012 -16.576 1.00 34.31 ? 1074 HOH A O 1 HETATM 4351 O O . HOH R 7 . ? 15.603 -59.865 -29.959 1.00 17.80 ? 1075 HOH A O 1 HETATM 4352 O O . HOH R 7 . ? 8.834 -62.444 -11.510 1.00 31.96 ? 1076 HOH A O 1 HETATM 4353 O O . HOH R 7 . ? 42.129 -54.664 -16.303 1.00 18.48 ? 1077 HOH A O 1 HETATM 4354 O O . HOH R 7 . ? 42.701 -65.601 -28.304 1.00 49.10 ? 1078 HOH A O 1 HETATM 4355 O O . HOH R 7 . ? 48.419 -59.503 -23.054 1.00 47.70 ? 1079 HOH A O 1 HETATM 4356 O O . HOH R 7 . ? 45.277 -68.800 -15.552 1.00 39.80 ? 1080 HOH A O 1 HETATM 4357 O O . HOH R 7 . ? 32.953 -33.476 -24.290 1.00 41.86 ? 1081 HOH A O 1 HETATM 4358 O O . HOH R 7 . ? 44.802 -67.559 -19.553 1.00 32.48 ? 1082 HOH A O 1 HETATM 4359 O O . HOH R 7 . ? 39.037 -55.653 -40.654 1.00 28.49 ? 1083 HOH A O 1 HETATM 4360 O O . HOH R 7 . ? 9.380 -53.719 -5.627 1.00 34.09 ? 1084 HOH A O 1 HETATM 4361 O O . HOH R 7 . ? 35.998 -51.366 -38.157 1.00 38.59 ? 1085 HOH A O 1 HETATM 4362 O O . HOH R 7 . ? 15.753 -64.392 -5.394 1.00 24.58 ? 1086 HOH A O 1 HETATM 4363 O O . HOH R 7 . ? 18.340 -67.242 -22.442 1.00 37.10 ? 1087 HOH A O 1 HETATM 4364 O O . HOH R 7 . ? 38.163 -65.156 -32.321 1.00 39.59 ? 1088 HOH A O 1 HETATM 4365 O O . HOH R 7 . ? 45.380 -47.507 -22.319 1.00 14.30 ? 1089 HOH A O 1 HETATM 4366 O O . HOH R 7 . ? 16.285 -70.845 2.876 1.00 37.10 ? 1090 HOH A O 1 HETATM 4367 O O . HOH R 7 . ? 19.319 -58.109 -28.740 1.00 24.53 ? 1091 HOH A O 1 HETATM 4368 O O . HOH R 7 . ? 18.276 -55.333 -35.947 1.00 51.11 ? 1092 HOH A O 1 HETATM 4369 O O . HOH R 7 . ? 24.876 -73.610 -12.165 1.00 35.57 ? 1093 HOH A O 1 HETATM 4370 O O . HOH R 7 . ? 33.531 -54.401 -19.427 1.00 14.16 ? 1094 HOH A O 1 HETATM 4371 O O . HOH R 7 . ? 19.529 -42.545 -9.258 1.00 32.14 ? 1095 HOH A O 1 HETATM 4372 O O . HOH R 7 . ? 37.428 -64.835 -25.853 1.00 25.96 ? 1096 HOH A O 1 HETATM 4373 O O . HOH R 7 . ? 25.054 -53.308 2.637 1.00 33.79 ? 1097 HOH A O 1 HETATM 4374 O O . HOH R 7 . ? 38.713 -60.617 -33.363 1.00 39.66 ? 1098 HOH A O 1 HETATM 4375 O O . HOH R 7 . ? 31.324 -57.671 -33.859 1.00 43.24 ? 1099 HOH A O 1 HETATM 4376 O O . HOH R 7 . ? 28.531 -54.164 -35.811 1.00 20.77 ? 1100 HOH A O 1 HETATM 4377 O O . HOH R 7 . ? 25.075 -41.503 -32.693 1.00 18.93 ? 1101 HOH A O 1 HETATM 4378 O O . HOH R 7 . ? 22.619 -42.823 -12.527 1.00 12.66 ? 1102 HOH A O 1 HETATM 4379 O O . HOH R 7 . ? 14.847 -69.951 -7.168 0.50 21.42 ? 1103 HOH A O 1 HETATM 4380 O O . HOH R 7 . ? 40.759 -38.967 -22.858 1.00 12.28 ? 1104 HOH A O 1 HETATM 4381 O O . HOH R 7 . ? 37.248 -69.863 -27.453 1.00 44.10 ? 1105 HOH A O 1 HETATM 4382 O O . HOH R 7 . ? 11.355 -60.895 -15.936 1.00 44.39 ? 1106 HOH A O 1 HETATM 4383 O O . HOH R 7 . ? 16.451 -67.893 -13.189 1.00 37.18 ? 1107 HOH A O 1 HETATM 4384 O O . HOH R 7 . ? 34.055 -49.776 -8.261 1.00 35.68 ? 1108 HOH A O 1 HETATM 4385 O O . HOH R 7 . ? 40.963 -42.700 -34.343 0.50 16.06 ? 1109 HOH A O 1 HETATM 4386 O O . HOH R 7 . ? 40.150 -36.375 -16.285 1.00 25.10 ? 1110 HOH A O 1 HETATM 4387 O O . HOH R 7 . ? 34.545 -43.027 -35.498 1.00 24.26 ? 1111 HOH A O 1 HETATM 4388 O O . HOH R 7 . ? 38.576 -71.752 -21.961 1.00 34.96 ? 1112 HOH A O 1 HETATM 4389 O O . HOH R 7 . ? 25.943 -73.244 -21.369 1.00 36.47 ? 1113 HOH A O 1 HETATM 4390 O O . HOH R 7 . ? 11.450 -64.730 0.739 1.00 19.64 ? 1114 HOH A O 1 HETATM 4391 O O . HOH R 7 . ? 31.292 -71.938 -16.564 1.00 35.54 ? 1115 HOH A O 1 HETATM 4392 O O . HOH R 7 . ? 15.203 -40.226 -12.114 1.00 39.79 ? 1116 HOH A O 1 HETATM 4393 O O . HOH R 7 . ? 16.003 -43.348 -11.016 1.00 27.07 ? 1117 HOH A O 1 HETATM 4394 O O . HOH R 7 . ? 20.634 -55.616 -29.476 1.00 23.28 ? 1118 HOH A O 1 HETATM 4395 O O . HOH R 7 . ? 45.008 -45.519 -20.493 1.00 17.67 ? 1119 HOH A O 1 HETATM 4396 O O . HOH R 7 . ? 29.131 -63.928 -34.895 1.00 34.51 ? 1120 HOH A O 1 HETATM 4397 O O . HOH R 7 . ? 20.557 -48.898 0.189 0.50 18.17 ? 1121 HOH A O 1 HETATM 4398 O O . HOH R 7 . ? 34.005 -59.998 -11.330 1.00 15.02 ? 1122 HOH A O 1 HETATM 4399 O O . HOH R 7 . ? 17.199 -36.305 -11.316 1.00 47.52 ? 1123 HOH A O 1 HETATM 4400 O O . HOH R 7 . ? 22.589 -72.580 0.856 1.00 39.26 ? 1124 HOH A O 1 HETATM 4401 O O . HOH R 7 . ? 42.387 -39.739 -27.059 1.00 19.12 ? 1125 HOH A O 1 HETATM 4402 O O . HOH R 7 . ? 21.479 -49.788 -10.075 1.00 17.62 ? 805 HOH A O 1 HETATM 4403 O O . HOH R 7 . ? 47.815 -51.496 -33.475 1.00 42.95 ? 1127 HOH A O 1 HETATM 4404 O O . HOH R 7 . ? 20.602 -76.402 -7.328 1.00 54.57 ? 1128 HOH A O 1 HETATM 4405 O O . HOH R 7 . ? 34.623 -71.708 -15.661 1.00 35.89 ? 1129 HOH A O 1 HETATM 4406 O O . HOH R 7 . ? 41.377 -51.637 -11.374 1.00 34.27 ? 1130 HOH A O 1 HETATM 4407 O O . HOH R 7 . ? 51.241 -45.813 -25.188 1.00 32.85 ? 1131 HOH A O 1 HETATM 4408 O O . HOH R 7 . ? 41.518 -49.094 -38.439 1.00 35.00 ? 1132 HOH A O 1 HETATM 4409 O O . HOH R 7 . ? 39.664 -65.594 -29.838 1.00 43.46 ? 1133 HOH A O 1 HETATM 4410 O O . HOH R 7 . ? 29.687 -34.120 -25.307 1.00 55.24 ? 1134 HOH A O 1 HETATM 4411 O O . HOH R 7 . ? 8.765 -41.554 -18.555 1.00 47.26 ? 1135 HOH A O 1 HETATM 4412 O O . HOH R 7 . ? 17.923 -62.837 -25.349 0.50 13.07 ? 1136 HOH A O 1 HETATM 4413 O O . HOH R 7 . ? 7.329 -52.137 -12.873 1.00 27.74 ? 1137 HOH A O 1 HETATM 4414 O O . HOH R 7 . ? 8.673 -42.969 -21.834 0.50 29.56 ? 1138 HOH A O 1 HETATM 4415 O O . HOH R 7 . ? 22.349 -64.518 5.853 1.00 46.07 ? 1139 HOH A O 1 HETATM 4416 O O . HOH R 7 . ? 21.327 -39.385 -12.356 1.00 23.35 ? 1140 HOH A O 1 HETATM 4417 O O . HOH R 7 . ? 11.408 -68.885 -5.411 1.00 23.20 ? 1141 HOH A O 1 HETATM 4418 O O . HOH R 7 . ? 16.282 -42.427 -28.618 1.00 33.03 ? 1142 HOH A O 1 HETATM 4419 O O . HOH R 7 . ? 35.008 -56.457 -6.593 1.00 25.91 ? 1143 HOH A O 1 HETATM 4420 O O . HOH R 7 . ? 15.387 -48.524 -2.269 1.00 25.20 ? 1144 HOH A O 1 HETATM 4421 O O . HOH R 7 . ? 21.247 -70.432 -1.753 1.00 34.56 ? 1145 HOH A O 1 HETATM 4422 O O . HOH R 7 . ? 11.545 -47.887 -21.931 0.50 19.51 ? 1146 HOH A O 1 HETATM 4423 O O . HOH R 7 . ? 11.420 -66.781 -11.861 1.00 26.79 ? 1147 HOH A O 1 HETATM 4424 O O . HOH R 7 . ? 38.506 -69.354 -16.081 1.00 27.40 ? 1148 HOH A O 1 HETATM 4425 O O . HOH R 7 . ? 46.767 -55.119 -34.442 1.00 44.95 ? 1149 HOH A O 1 HETATM 4426 O O . HOH R 7 . ? 38.249 -36.018 -28.586 1.00 23.23 ? 1150 HOH A O 1 HETATM 4427 O O . HOH R 7 . ? 44.328 -41.407 -28.162 1.00 45.60 ? 1151 HOH A O 1 HETATM 4428 O O . HOH R 7 . ? 40.291 -42.441 -36.311 0.50 20.93 ? 1152 HOH A O 1 HETATM 4429 O O . HOH R 7 . ? 12.685 -45.331 -22.166 1.00 19.33 ? 1153 HOH A O 1 HETATM 4430 O O . HOH R 7 . ? 19.976 -43.719 -12.663 1.00 15.26 ? 1154 HOH A O 1 HETATM 4431 O O . HOH R 7 . ? 34.995 -62.954 -4.578 1.00 40.86 ? 1155 HOH A O 1 HETATM 4432 O O . HOH R 7 . ? 20.515 -63.534 -21.378 1.00 35.28 ? 1156 HOH A O 1 HETATM 4433 O O . HOH R 7 . ? 42.372 -44.980 -33.877 1.00 26.27 ? 1157 HOH A O 1 HETATM 4434 O O . HOH R 7 . ? 33.038 -34.978 -2.354 1.00 43.19 ? 1158 HOH A O 1 HETATM 4435 O O . HOH R 7 . ? 23.947 -49.127 -36.737 1.00 23.95 ? 1159 HOH A O 1 HETATM 4436 O O . HOH R 7 . ? 36.686 -57.259 -8.561 1.00 17.97 ? 1160 HOH A O 1 HETATM 4437 O O . HOH R 7 . ? 10.451 -59.914 -0.918 1.00 19.26 ? 1161 HOH A O 1 HETATM 4438 O O . HOH R 7 . ? 17.843 -62.317 -27.260 0.50 14.87 ? 1162 HOH A O 1 HETATM 4439 O O . HOH R 7 . ? 19.093 -52.485 -36.426 1.00 36.51 ? 1163 HOH A O 1 HETATM 4440 O O . HOH R 7 . ? 36.654 -37.652 -19.068 1.00 25.70 ? 1164 HOH A O 1 HETATM 4441 O O . HOH R 7 . ? 8.056 -45.586 -10.990 1.00 47.41 ? 1165 HOH A O 1 HETATM 4442 O O . HOH R 7 . ? 34.471 -47.063 -43.387 1.00 55.60 ? 1166 HOH A O 1 HETATM 4443 O O . HOH R 7 . ? 10.476 -61.141 1.708 1.00 19.62 ? 1167 HOH A O 1 HETATM 4444 O O . HOH R 7 . ? 29.307 -50.395 -40.262 1.00 50.12 ? 1168 HOH A O 1 HETATM 4445 O O . HOH R 7 . ? 15.124 -49.299 -26.810 1.00 26.97 ? 1169 HOH A O 1 HETATM 4446 O O . HOH R 7 . ? 21.783 -71.347 4.247 1.00 34.53 ? 1170 HOH A O 1 HETATM 4447 O O . HOH R 7 . ? 19.918 -56.054 4.404 1.00 29.58 ? 1171 HOH A O 1 HETATM 4448 O O . HOH R 7 . ? 18.940 -45.974 -5.172 1.00 34.13 ? 1172 HOH A O 1 HETATM 4449 O O . HOH R 7 . ? 7.384 -59.295 -3.425 1.00 18.47 ? 1173 HOH A O 1 HETATM 4450 O O . HOH R 7 . ? 37.202 -51.877 -10.329 1.00 34.49 ? 1174 HOH A O 1 HETATM 4451 O O . HOH R 7 . ? 32.232 -53.461 -8.077 1.00 36.08 ? 1175 HOH A O 1 HETATM 4452 O O . HOH R 7 . ? 16.891 -58.998 2.263 1.00 28.75 ? 1176 HOH A O 1 HETATM 4453 O O . HOH R 7 . ? 27.981 -47.709 -39.899 1.00 35.38 ? 1177 HOH A O 1 HETATM 4454 O O . HOH R 7 . ? 17.653 -69.494 -4.596 1.00 34.87 ? 1178 HOH A O 1 HETATM 4455 O O . HOH R 7 . ? 28.261 -32.725 -22.679 1.00 54.60 ? 1179 HOH A O 1 HETATM 4456 O O . HOH R 7 . ? 40.796 -59.152 -34.612 1.00 40.02 ? 1180 HOH A O 1 HETATM 4457 O O . HOH R 7 . ? 12.381 -52.340 -19.694 1.00 20.48 ? 1181 HOH A O 1 HETATM 4458 O O . HOH R 7 . ? 32.542 -61.990 6.562 1.00 43.73 ? 1182 HOH A O 1 HETATM 4459 O O . HOH R 7 . ? 41.037 -32.627 -10.771 1.00 25.80 ? 1183 HOH A O 1 HETATM 4460 O O . HOH R 7 . ? 31.499 -44.101 -4.003 1.00 26.76 ? 1184 HOH A O 1 HETATM 4461 O O . HOH R 7 . ? 14.616 -44.330 -27.106 1.00 51.24 ? 1185 HOH A O 1 HETATM 4462 O O . HOH R 7 . ? 6.317 -45.529 -13.626 1.00 41.14 ? 1186 HOH A O 1 HETATM 4463 O O . HOH R 7 . ? 47.881 -57.148 -30.571 1.00 41.43 ? 1187 HOH A O 1 HETATM 4464 O O . HOH R 7 . ? 19.375 -65.002 -25.749 1.00 33.92 ? 1188 HOH A O 1 HETATM 4465 O O . HOH R 7 . ? 29.616 -59.134 -32.453 1.00 28.10 ? 1189 HOH A O 1 HETATM 4466 O O . HOH R 7 . ? 29.964 -36.468 -36.081 1.00 47.54 ? 1190 HOH A O 1 HETATM 4467 O O . HOH R 7 . ? 19.669 -61.684 9.288 1.00 53.20 ? 1191 HOH A O 1 HETATM 4468 O O . HOH R 7 . ? 45.987 -53.060 -16.874 1.00 23.52 ? 1192 HOH A O 1 HETATM 4469 O O . HOH R 7 . ? 25.075 -43.249 -42.595 0.50 23.18 ? 1193 HOH A O 1 HETATM 4470 O O . HOH R 7 . ? 14.589 -38.504 -24.109 1.00 43.40 ? 1194 HOH A O 1 HETATM 4471 O O . HOH R 7 . ? 42.737 -48.600 -13.985 1.00 16.04 ? 1195 HOH A O 1 HETATM 4472 O O . HOH R 7 . ? 12.931 -48.366 -6.276 1.00 37.18 ? 1196 HOH A O 1 HETATM 4473 O O . HOH R 7 . ? 22.365 -39.354 -30.023 1.00 27.72 ? 1197 HOH A O 1 HETATM 4474 O O . HOH R 7 . ? 44.161 -43.452 -15.515 1.00 11.92 ? 1198 HOH A O 1 HETATM 4475 O O . HOH R 7 . ? 28.737 -36.319 -27.024 1.00 37.65 ? 1199 HOH A O 1 HETATM 4476 O O . HOH R 7 . ? 42.949 -65.911 -9.765 1.00 24.92 ? 1200 HOH A O 1 HETATM 4477 O O . HOH R 7 . ? 46.001 -60.584 -13.092 1.00 41.11 ? 1201 HOH A O 1 HETATM 4478 O O . HOH R 7 . ? 21.110 -55.903 -36.247 1.00 47.20 ? 1202 HOH A O 1 HETATM 4479 O O . HOH R 7 . ? 11.911 -42.532 -21.753 1.00 26.67 ? 1203 HOH A O 1 HETATM 4480 O O . HOH R 7 . ? 46.343 -43.095 -25.677 0.50 19.61 ? 1204 HOH A O 1 HETATM 4481 O O . HOH R 7 . ? 25.754 -36.673 -27.372 1.00 27.68 ? 1205 HOH A O 1 HETATM 4482 O O . HOH R 7 . ? 43.389 -45.576 -36.101 1.00 35.24 ? 1206 HOH A O 1 HETATM 4483 O O . HOH R 7 . ? 39.006 -36.396 -34.355 1.00 23.05 ? 1207 HOH A O 1 HETATM 4484 O O . HOH R 7 . ? 18.294 -73.368 -7.491 1.00 45.52 ? 1208 HOH A O 1 HETATM 4485 O O . HOH R 7 . ? 38.640 -36.973 -46.137 1.00 20.63 ? 1209 HOH A O 1 HETATM 4486 O O . HOH R 7 . ? 36.083 -38.204 -22.900 1.00 29.85 ? 1210 HOH A O 1 HETATM 4487 O O . HOH R 7 . ? 11.131 -39.946 -12.198 1.00 47.81 ? 1211 HOH A O 1 HETATM 4488 O O . HOH R 7 . ? 8.357 -57.957 -15.458 1.00 24.64 ? 1212 HOH A O 1 HETATM 4489 O O . HOH R 7 . ? 35.869 -39.319 -6.354 1.00 30.19 ? 1213 HOH A O 1 HETATM 4490 O O . HOH R 7 . ? 44.668 -55.462 -36.168 1.00 39.28 ? 1214 HOH A O 1 HETATM 4491 O O . HOH R 7 . ? 14.779 -62.909 7.425 1.00 44.65 ? 1215 HOH A O 1 HETATM 4492 O O . HOH R 7 . ? 28.046 -54.779 2.347 1.00 40.36 ? 1216 HOH A O 1 HETATM 4493 O O . HOH R 7 . ? 50.880 -58.597 -26.103 1.00 28.14 ? 1217 HOH A O 1 HETATM 4494 O O . HOH R 7 . ? 19.926 -78.119 -4.894 1.00 63.75 ? 1218 HOH A O 1 HETATM 4495 O O . HOH R 7 . ? 32.182 -73.352 -12.759 1.00 43.10 ? 1219 HOH A O 1 HETATM 4496 O O . HOH R 7 . ? 41.570 -38.269 -17.440 1.00 15.36 ? 1220 HOH A O 1 HETATM 4497 O O . HOH R 7 . ? 35.099 -64.062 -34.447 1.00 50.16 ? 1221 HOH A O 1 HETATM 4498 O O . HOH R 7 . ? 36.559 -54.390 -41.367 1.00 40.53 ? 1222 HOH A O 1 HETATM 4499 O O . HOH R 7 . ? 9.501 -49.467 -18.711 1.00 42.77 ? 1223 HOH A O 1 HETATM 4500 O O . HOH R 7 . ? 38.575 -58.646 -39.867 1.00 34.06 ? 1224 HOH A O 1 HETATM 4501 O O . HOH R 7 . ? 31.361 -75.115 -19.567 1.00 44.96 ? 1225 HOH A O 1 HETATM 4502 O O . HOH R 7 . ? 39.243 -38.587 -4.562 1.00 20.86 ? 1226 HOH A O 1 HETATM 4503 O O . HOH R 7 . ? 29.837 -53.904 -2.616 1.00 43.17 ? 1227 HOH A O 1 HETATM 4504 O O . HOH R 7 . ? 47.098 -63.386 -14.883 1.00 28.99 ? 1228 HOH A O 1 HETATM 4505 O O . HOH R 7 . ? 20.858 -73.618 -0.898 1.00 34.65 ? 1229 HOH A O 1 HETATM 4506 O O . HOH R 7 . ? 34.425 -34.718 -10.612 1.00 21.65 ? 1230 HOH A O 1 HETATM 4507 O O . HOH R 7 . ? 20.000 -58.433 -36.036 1.00 50.78 ? 1231 HOH A O 1 HETATM 4508 O O . HOH R 7 . ? 15.000 -44.027 -4.300 1.00 47.96 ? 1232 HOH A O 1 HETATM 4509 O O . HOH R 7 . ? 28.436 -75.089 -25.203 1.00 39.34 ? 1233 HOH A O 1 HETATM 4510 O O . HOH R 7 . ? 30.579 -54.615 -5.723 1.00 36.52 ? 1234 HOH A O 1 HETATM 4511 O O . HOH R 7 . ? 14.854 -59.580 -22.696 1.00 30.53 ? 1235 HOH A O 1 HETATM 4512 O O . HOH R 7 . ? 28.881 -51.241 -1.394 1.00 50.76 ? 1236 HOH A O 1 HETATM 4513 O O . HOH R 7 . ? 41.490 -57.960 -10.221 1.00 35.10 ? 1237 HOH A O 1 HETATM 4514 O O . HOH R 7 . ? 36.387 -33.698 -28.321 1.00 42.89 ? 1238 HOH A O 1 HETATM 4515 O O . HOH R 7 . ? 51.323 -51.301 -25.731 1.00 36.13 ? 1239 HOH A O 1 HETATM 4516 O O . HOH R 7 . ? 26.469 -40.972 -41.448 1.00 38.92 ? 1240 HOH A O 1 HETATM 4517 O O . HOH R 7 . ? 10.451 -68.633 -8.013 1.00 24.00 ? 1241 HOH A O 1 HETATM 4518 O O . HOH R 7 . ? 41.215 -71.547 -12.577 1.00 46.96 ? 1242 HOH A O 1 HETATM 4519 O O . HOH R 7 . ? 34.297 -32.573 -33.747 1.00 25.10 ? 1243 HOH A O 1 HETATM 4520 O O . HOH R 7 . ? 13.117 -41.181 -24.112 1.00 56.06 ? 1244 HOH A O 1 HETATM 4521 O O . HOH R 7 . ? 27.256 -56.416 4.669 1.00 47.80 ? 1245 HOH A O 1 HETATM 4522 O O . HOH R 7 . ? 17.984 -60.101 -25.979 1.00 40.53 ? 1246 HOH A O 1 HETATM 4523 O O . HOH R 7 . ? 21.033 -59.517 7.957 1.00 56.03 ? 1247 HOH A O 1 HETATM 4524 O O . HOH R 7 . ? 9.181 -48.015 -7.441 1.00 46.96 ? 1248 HOH A O 1 HETATM 4525 O O . HOH R 7 . ? 10.718 -56.023 -18.686 1.00 29.02 ? 1249 HOH A O 1 HETATM 4526 O O . HOH R 7 . ? 49.170 -47.838 -29.879 1.00 47.76 ? 1250 HOH A O 1 HETATM 4527 O O . HOH R 7 . ? 17.856 -46.790 -3.010 1.00 37.63 ? 1251 HOH A O 1 HETATM 4528 O O . HOH R 7 . ? 32.659 -33.023 -16.241 1.00 42.40 ? 1252 HOH A O 1 HETATM 4529 O O . HOH R 7 . ? 38.380 -65.853 -6.569 1.00 45.50 ? 1253 HOH A O 1 HETATM 4530 O O . HOH R 7 . ? 36.200 -43.190 -37.565 1.00 40.19 ? 1254 HOH A O 1 HETATM 4531 O O . HOH R 7 . ? 30.954 -74.213 -26.395 1.00 38.50 ? 1255 HOH A O 1 HETATM 4532 O O . HOH R 7 . ? 45.824 -63.134 -19.724 1.00 42.69 ? 1256 HOH A O 1 HETATM 4533 O O . HOH R 7 . ? 35.052 -33.914 -17.343 1.00 57.72 ? 1257 HOH A O 1 HETATM 4534 O O . HOH R 7 . ? 42.828 -49.465 -16.462 1.00 24.96 ? 1258 HOH A O 1 HETATM 4535 O O . HOH R 7 . ? 29.831 -66.497 -34.168 1.00 38.98 ? 1259 HOH A O 1 HETATM 4536 O O . HOH R 7 . ? 48.182 -65.207 -13.367 1.00 50.39 ? 1260 HOH A O 1 HETATM 4537 O O . HOH R 7 . ? 8.618 -50.039 -15.367 1.00 40.45 ? 1261 HOH A O 1 HETATM 4538 O O . HOH R 7 . ? 43.598 -48.249 -37.201 1.00 45.55 ? 1262 HOH A O 1 HETATM 4539 O O . HOH R 7 . ? 16.395 -56.316 2.434 1.00 35.07 ? 1263 HOH A O 1 HETATM 4540 O O . HOH R 7 . ? 26.551 -42.520 -37.691 1.00 30.98 ? 1264 HOH A O 1 HETATM 4541 O O . HOH R 7 . ? 8.628 -42.695 -10.612 1.00 53.14 ? 1265 HOH A O 1 HETATM 4542 O O . HOH R 7 . ? 33.181 -65.893 -2.302 1.00 37.28 ? 1266 HOH A O 1 HETATM 4543 O O . HOH R 7 . ? 22.146 -61.208 6.082 1.00 51.81 ? 1267 HOH A O 1 HETATM 4544 O O . HOH R 7 . ? 14.174 -51.219 -24.466 1.00 30.42 ? 1268 HOH A O 1 HETATM 4545 O O . HOH R 7 . ? 19.936 -37.124 -18.430 1.00 42.89 ? 1269 HOH A O 1 HETATM 4546 O O . HOH R 7 . ? 30.299 -40.625 -38.758 1.00 46.38 ? 1270 HOH A O 1 HETATM 4547 O O . HOH R 7 . ? 41.923 -61.580 -28.594 1.00 28.82 ? 1271 HOH A O 1 HETATM 4548 O O . HOH R 7 . ? 20.131 -68.286 -18.768 1.00 48.51 ? 1272 HOH A O 1 HETATM 4549 O O . HOH R 7 . ? 47.551 -43.408 -24.162 0.50 21.18 ? 1273 HOH A O 1 HETATM 4550 O O . HOH R 7 . ? 42.439 -40.537 -16.296 1.00 15.07 ? 1274 HOH A O 1 HETATM 4551 O O . HOH R 7 . ? 27.846 -43.558 -42.678 1.00 41.90 ? 1275 HOH A O 1 HETATM 4552 O O . HOH R 7 . ? 22.740 -48.725 0.135 0.50 27.01 ? 1276 HOH A O 1 HETATM 4553 O O . HOH R 7 . ? 25.517 -36.339 -24.683 1.00 28.34 ? 1277 HOH A O 1 HETATM 4554 O O . HOH R 7 . ? 3.866 -51.848 -10.925 1.00 44.76 ? 1278 HOH A O 1 HETATM 4555 O O . HOH R 7 . ? 43.312 -53.619 -40.220 0.50 26.46 ? 1279 HOH A O 1 HETATM 4556 O O . HOH R 7 . ? 37.391 -72.882 -24.075 1.00 42.71 ? 1280 HOH A O 1 HETATM 4557 O O . HOH R 7 . ? 43.031 -59.709 -29.770 1.00 41.44 ? 1281 HOH A O 1 HETATM 4558 O O . HOH R 7 . ? 11.222 -55.764 -2.834 1.00 34.35 ? 1282 HOH A O 1 HETATM 4559 O O . HOH R 7 . ? 6.890 -50.178 -5.319 1.00 55.70 ? 1283 HOH A O 1 HETATM 4560 O O . HOH R 7 . ? 21.632 -53.676 -37.570 1.00 53.80 ? 1284 HOH A O 1 HETATM 4561 O O . HOH R 7 . ? 27.446 -37.375 -33.081 1.00 54.53 ? 1285 HOH A O 1 HETATM 4562 O O . HOH R 7 . ? 26.479 -42.176 -7.893 1.00 30.10 ? 1286 HOH A O 1 HETATM 4563 O O . HOH R 7 . ? 19.724 -46.724 -0.903 1.00 46.61 ? 1287 HOH A O 1 HETATM 4564 O O . HOH R 7 . ? 21.183 -49.013 -38.280 1.00 35.08 ? 1288 HOH A O 1 HETATM 4565 O O . HOH R 7 . ? 8.105 -60.256 -14.583 1.00 41.79 ? 1289 HOH A O 1 HETATM 4566 O O . HOH R 7 . ? 24.093 -52.051 -37.162 1.00 44.60 ? 1290 HOH A O 1 HETATM 4567 O O . HOH R 7 . ? 10.957 -66.839 2.467 1.00 41.34 ? 1291 HOH A O 1 HETATM 4568 O O . HOH R 7 . ? 22.755 -67.327 6.353 1.00 49.29 ? 1292 HOH A O 1 HETATM 4569 O O . HOH R 7 . ? 30.579 -45.182 -6.566 1.00 28.55 ? 1293 HOH A O 1 HETATM 4570 O O . HOH R 7 . ? 39.270 -36.366 -21.988 1.00 42.80 ? 1294 HOH A O 1 HETATM 4571 O O . HOH R 7 . ? 27.666 -77.187 -26.800 1.00 44.95 ? 1295 HOH A O 1 HETATM 4572 O O . HOH R 7 . ? 43.876 -51.298 -12.941 1.00 36.41 ? 1296 HOH A O 1 HETATM 4573 O O . HOH R 7 . ? 24.908 -71.949 -18.956 1.00 36.53 ? 1297 HOH A O 1 HETATM 4574 O O . HOH R 7 . ? 38.496 -72.136 -26.278 1.00 49.35 ? 1298 HOH A O 1 HETATM 4575 O O . HOH R 7 . ? 30.068 -52.708 -38.419 1.00 43.90 ? 1299 HOH A O 1 HETATM 4576 O O . HOH R 7 . ? 18.229 -40.179 -28.064 1.00 47.56 ? 1300 HOH A O 1 HETATM 4577 O O . HOH R 7 . ? 16.235 -71.401 -5.615 1.00 37.57 ? 1301 HOH A O 1 HETATM 4578 O O . HOH R 7 . ? 36.561 -70.865 -17.237 1.00 29.95 ? 1302 HOH A O 1 HETATM 4579 O O . HOH R 7 . ? 27.152 -36.363 -9.870 1.00 45.36 ? 1303 HOH A O 1 HETATM 4580 O O . HOH R 7 . ? 40.973 -70.719 -15.152 1.00 40.04 ? 1304 HOH A O 1 HETATM 4581 O O . HOH R 7 . ? 35.150 -60.959 -2.965 1.00 42.15 ? 1305 HOH A O 1 HETATM 4582 O O . HOH R 7 . ? 51.725 -58.228 -28.827 1.00 59.64 ? 1306 HOH A O 1 HETATM 4583 O O . HOH R 7 . ? 11.209 -51.703 -5.253 1.00 40.69 ? 1307 HOH A O 1 HETATM 4584 O O . HOH R 7 . ? 10.472 -58.183 -17.195 1.00 34.53 ? 1308 HOH A O 1 HETATM 4585 O O . HOH R 7 . ? 33.661 -34.843 -29.645 1.00 41.28 ? 1309 HOH A O 1 HETATM 4586 O O . HOH R 7 . ? 32.029 -54.654 -0.652 1.00 46.64 ? 1310 HOH A O 1 HETATM 4587 O O . HOH R 7 . ? 17.039 -37.951 -19.588 1.00 42.02 ? 1311 HOH A O 1 HETATM 4588 O O . HOH R 7 . ? 51.769 -52.879 -23.923 1.00 40.59 ? 1312 HOH A O 1 HETATM 4589 O O . HOH R 7 . ? 28.234 -74.859 -16.225 1.00 54.98 ? 1313 HOH A O 1 HETATM 4590 O O . HOH R 7 . ? 12.893 -48.400 -3.574 1.00 36.50 ? 1314 HOH A O 1 HETATM 4591 O O . HOH R 7 . ? 38.398 -49.719 -8.395 1.00 27.00 ? 1315 HOH A O 1 HETATM 4592 O O . HOH R 7 . ? 28.044 -44.908 -7.101 1.00 27.37 ? 1316 HOH A O 1 HETATM 4593 O O . HOH R 7 . ? 16.543 -57.687 -28.475 1.00 28.62 ? 1317 HOH A O 1 HETATM 4594 O O . HOH R 7 . ? 17.804 -38.705 -25.780 1.00 41.58 ? 1318 HOH A O 1 HETATM 4595 O O . HOH R 7 . ? 30.109 -73.999 -1.615 1.00 55.35 ? 1319 HOH A O 1 HETATM 4596 O O . HOH R 7 . ? 25.571 -40.633 -35.328 1.00 39.04 ? 1320 HOH A O 1 HETATM 4597 O O . HOH R 7 . ? 14.240 -46.641 -25.814 0.50 21.85 ? 1321 HOH A O 1 HETATM 4598 O O . HOH R 7 . ? 14.169 -67.978 -15.108 1.00 45.35 ? 1322 HOH A O 1 HETATM 4599 O O . HOH R 7 . ? 52.782 -55.482 -25.544 1.00 45.43 ? 1323 HOH A O 1 HETATM 4600 O O . HOH R 7 . ? 2.760 -54.979 -15.397 1.00 49.91 ? 1324 HOH A O 1 HETATM 4601 O O . HOH R 7 . ? 35.138 -74.386 -24.414 1.00 40.48 ? 1325 HOH A O 1 HETATM 4602 O O . HOH R 7 . ? 28.386 -58.621 -34.655 1.00 42.99 ? 1326 HOH A O 1 HETATM 4603 O O . HOH R 7 . ? 11.784 -66.170 5.923 1.00 44.84 ? 1327 HOH A O 1 HETATM 4604 O O . HOH R 7 . ? 22.087 -41.553 -10.079 1.00 23.47 ? 1328 HOH A O 1 HETATM 4605 O O . HOH R 7 . ? 8.812 -44.500 -24.192 1.00 52.31 ? 1329 HOH A O 1 HETATM 4606 O O . HOH R 7 . ? 23.854 -46.701 -39.527 1.00 40.22 ? 1330 HOH A O 1 HETATM 4607 O O . HOH R 7 . ? 22.739 -36.282 -21.367 1.00 38.99 ? 1331 HOH A O 1 HETATM 4608 O O . HOH R 7 . ? 18.862 -69.777 -16.808 1.00 50.21 ? 1332 HOH A O 1 HETATM 4609 O O . HOH R 7 . ? 9.216 -38.792 -14.674 1.00 50.51 ? 1333 HOH A O 1 HETATM 4610 O O . HOH R 7 . ? 14.473 -37.128 -12.862 1.00 52.99 ? 1334 HOH A O 1 HETATM 4611 O O . HOH R 7 . ? 25.904 -54.551 -35.953 1.00 38.64 ? 1335 HOH A O 1 HETATM 4612 O O . HOH R 7 . ? 37.798 -73.339 -18.234 1.00 38.44 ? 1336 HOH A O 1 HETATM 4613 O O . HOH R 7 . ? 4.536 -56.994 -16.255 1.00 50.38 ? 1337 HOH A O 1 HETATM 4614 O O . HOH R 7 . ? 10.007 -52.975 -2.903 1.00 51.39 ? 1338 HOH A O 1 HETATM 4615 O O . HOH R 7 . ? 23.788 -41.459 -8.164 1.00 34.48 ? 1339 HOH A O 1 HETATM 4616 O O . HOH R 7 . ? 14.293 -45.158 -24.606 0.50 18.13 ? 1340 HOH A O 1 HETATM 4617 O O . HOH R 7 . ? 29.178 -56.928 -38.991 1.00 49.51 ? 1341 HOH A O 1 HETATM 4618 O O . HOH S 7 . ? 33.403 -35.291 3.650 0.50 36.45 ? 1001 HOH B O 1 HETATM 4619 O O . HOH S 7 . ? 49.602 -56.312 -21.629 0.50 20.74 ? 1002 HOH B O 1 HETATM 4620 O O . HOH S 7 . ? 59.314 -50.142 21.388 0.50 25.27 ? 1003 HOH B O 1 HETATM 4621 O O . HOH S 7 . ? 39.863 -29.573 14.404 1.00 39.62 ? 1004 HOH B O 1 HETATM 4622 O O . HOH S 7 . ? 52.058 -26.058 -16.186 1.00 39.20 ? 1005 HOH B O 1 HETATM 4623 O O . HOH S 7 . ? 36.180 -29.616 1.183 0.50 21.74 ? 1006 HOH B O 1 HETATM 4624 O O . HOH S 7 . ? 43.291 -25.027 1.254 1.00 29.26 ? 1007 HOH B O 1 HETATM 4625 O O . HOH S 7 . ? 67.034 -39.917 -5.648 1.00 35.73 ? 1008 HOH B O 1 HETATM 4626 O O . HOH S 7 . ? 76.758 -56.043 -0.870 1.00 30.98 ? 1009 HOH B O 1 HETATM 4627 O O . HOH S 7 . ? 63.601 -31.741 -21.894 1.00 40.13 ? 1010 HOH B O 1 HETATM 4628 O O . HOH S 7 . ? 50.174 -57.537 -9.945 1.00 22.68 ? 1011 HOH B O 1 HETATM 4629 O O . HOH S 7 . ? 63.613 -29.325 -28.333 1.00 45.68 ? 1012 HOH B O 1 HETATM 4630 O O . HOH S 7 . ? 45.278 -27.108 -1.319 1.00 21.58 ? 1013 HOH B O 1 HETATM 4631 O O . HOH S 7 . ? 59.978 -45.931 13.402 1.00 27.57 ? 1014 HOH B O 1 HETATM 4632 O O . HOH S 7 . ? 78.051 -52.767 0.035 1.00 19.14 ? 1015 HOH B O 1 HETATM 4633 O O . HOH S 7 . ? 49.439 -42.442 15.594 1.00 21.25 ? 1016 HOH B O 1 HETATM 4634 O O . HOH S 7 . ? 51.131 -20.619 -18.692 1.00 41.62 ? 1017 HOH B O 1 HETATM 4635 O O . HOH S 7 . ? 39.991 -25.311 9.761 1.00 27.44 ? 1018 HOH B O 1 HETATM 4636 O O . HOH S 7 . ? 62.375 -23.049 -16.613 1.00 16.07 ? 1019 HOH B O 1 HETATM 4637 O O . HOH S 7 . ? 31.712 -40.639 -0.710 1.00 39.12 ? 1020 HOH B O 1 HETATM 4638 O O . HOH S 7 . ? 50.137 -34.493 -26.604 1.00 29.42 ? 1021 HOH B O 1 HETATM 4639 O O . HOH S 7 . ? 46.859 -57.330 -14.349 0.50 28.25 ? 1022 HOH B O 1 HETATM 4640 O O . HOH S 7 . ? 64.796 -38.944 0.477 1.00 39.06 ? 1023 HOH B O 1 HETATM 4641 O O . HOH S 7 . ? 62.581 -32.396 1.002 1.00 14.76 ? 1024 HOH B O 1 HETATM 4642 O O . HOH S 7 . ? 58.989 -18.144 -5.049 1.00 22.77 ? 1025 HOH B O 1 HETATM 4643 O O . HOH S 7 . ? 67.352 -32.854 -16.413 1.00 33.17 ? 1026 HOH B O 1 HETATM 4644 O O . HOH S 7 . ? 62.071 -42.424 -7.801 1.00 24.75 ? 1027 HOH B O 1 HETATM 4645 O O . HOH S 7 . ? 63.601 -33.895 6.915 1.00 18.28 ? 1028 HOH B O 1 HETATM 4646 O O . HOH S 7 . ? 40.829 -44.909 12.188 1.00 45.84 ? 1029 HOH B O 1 HETATM 4647 O O . HOH S 7 . ? 66.547 -41.575 3.198 1.00 45.11 ? 1030 HOH B O 1 HETATM 4648 O O . HOH S 7 . ? 46.263 -25.014 -9.321 1.00 19.00 ? 1031 HOH B O 1 HETATM 4649 O O . HOH S 7 . ? 56.775 -55.903 -7.746 1.00 36.48 ? 1032 HOH B O 1 HETATM 4650 O O . HOH S 7 . ? 43.870 -30.690 13.823 1.00 36.37 ? 1033 HOH B O 1 HETATM 4651 O O . HOH S 7 . ? 62.482 -39.450 -7.655 1.00 18.30 ? 1034 HOH B O 1 HETATM 4652 O O . HOH S 7 . ? 42.183 -30.427 -7.112 1.00 38.71 ? 1035 HOH B O 1 HETATM 4653 O O . HOH S 7 . ? 42.783 -33.915 -5.392 1.00 29.91 ? 1036 HOH B O 1 HETATM 4654 O O . HOH S 7 . ? 35.027 -43.165 1.914 1.00 47.41 ? 1037 HOH B O 1 HETATM 4655 O O . HOH S 7 . ? 70.992 -21.704 -13.609 1.00 47.92 ? 1038 HOH B O 1 HETATM 4656 O O . HOH S 7 . ? 68.182 -57.912 -2.167 1.00 44.44 ? 1039 HOH B O 1 HETATM 4657 O O . HOH S 7 . ? 48.900 -23.021 -15.218 1.00 48.90 ? 1040 HOH B O 1 HETATM 4658 O O . HOH S 7 . ? 63.080 -54.693 -9.647 1.00 21.73 ? 1041 HOH B O 1 HETATM 4659 O O . HOH S 7 . ? 57.256 -17.131 -19.536 1.00 33.92 ? 1042 HOH B O 1 HETATM 4660 O O . HOH S 7 . ? 65.313 -52.057 7.466 1.00 27.02 ? 1043 HOH B O 1 HETATM 4661 O O . HOH S 7 . ? 59.677 -47.918 -16.689 1.00 35.73 ? 1044 HOH B O 1 HETATM 4662 O O . HOH S 7 . ? 41.771 -48.248 18.274 1.00 35.74 ? 1045 HOH B O 1 HETATM 4663 O O . HOH S 7 . ? 54.187 -40.213 -21.597 1.00 17.71 ? 1046 HOH B O 1 HETATM 4664 O O . HOH S 7 . ? 69.277 -26.567 -19.294 1.00 28.43 ? 1047 HOH B O 1 HETATM 4665 O O . HOH S 7 . ? 37.083 -36.945 -4.811 1.00 28.46 ? 1048 HOH B O 1 HETATM 4666 O O . HOH S 7 . ? 56.129 -47.774 -18.632 1.00 30.94 ? 1049 HOH B O 1 HETATM 4667 O O . HOH S 7 . ? 53.616 -35.706 -23.885 1.00 21.89 ? 1050 HOH B O 1 HETATM 4668 O O . HOH S 7 . ? 46.165 -26.696 -11.588 1.00 22.86 ? 1051 HOH B O 1 HETATM 4669 O O . HOH S 7 . ? 70.646 -52.376 2.435 1.00 33.07 ? 1052 HOH B O 1 HETATM 4670 O O . HOH S 7 . ? 59.880 -20.715 2.134 1.00 30.68 ? 1053 HOH B O 1 HETATM 4671 O O . HOH S 7 . ? 54.171 -23.472 -23.481 1.00 20.35 ? 1054 HOH B O 1 HETATM 4672 O O . HOH S 7 . ? 74.727 -46.039 -4.193 1.00 16.23 ? 1055 HOH B O 1 HETATM 4673 O O . HOH S 7 . ? 63.436 -48.640 -2.134 1.00 13.01 ? 1056 HOH B O 1 HETATM 4674 O O . HOH S 7 . ? 49.138 -34.027 11.367 1.00 23.56 ? 1057 HOH B O 1 HETATM 4675 O O . HOH S 7 . ? 43.097 -51.158 13.222 1.00 45.42 ? 1058 HOH B O 1 HETATM 4676 O O . HOH S 7 . ? 41.867 -36.499 -10.100 1.00 11.09 ? 1059 HOH B O 1 HETATM 4677 O O . HOH S 7 . ? 46.177 -30.101 13.026 1.00 24.50 ? 1060 HOH B O 1 HETATM 4678 O O . HOH S 7 . ? 64.016 -26.904 11.555 1.00 38.37 ? 1061 HOH B O 1 HETATM 4679 O O . HOH S 7 . ? 62.063 -56.579 7.145 1.00 23.90 ? 1062 HOH B O 1 HETATM 4680 O O . HOH S 7 . ? 63.537 -44.806 -7.401 1.00 16.98 ? 1063 HOH B O 1 HETATM 4681 O O . HOH S 7 . ? 58.702 -16.441 -12.962 1.00 26.71 ? 1064 HOH B O 1 HETATM 4682 O O . HOH S 7 . ? 49.732 -18.980 -10.874 1.00 34.37 ? 1065 HOH B O 1 HETATM 4683 O O . HOH S 7 . ? 33.452 -36.180 0.003 1.00 33.56 ? 1066 HOH B O 1 HETATM 4684 O O . HOH S 7 . ? 52.300 -55.433 15.429 1.00 33.67 ? 1067 HOH B O 1 HETATM 4685 O O . HOH S 7 . ? 40.183 -46.136 8.587 1.00 31.17 ? 1068 HOH B O 1 HETATM 4686 O O . HOH S 7 . ? 49.366 -23.247 2.217 1.00 14.98 ? 1069 HOH B O 1 HETATM 4687 O O . HOH S 7 . ? 57.649 -55.695 -4.639 1.00 32.70 ? 1070 HOH B O 1 HETATM 4688 O O . HOH S 7 . ? 63.633 -55.986 1.076 1.00 30.51 ? 1071 HOH B O 1 HETATM 4689 O O . HOH S 7 . ? 44.830 -40.890 -14.654 1.00 13.30 ? 1072 HOH B O 1 HETATM 4690 O O . HOH S 7 . ? 45.669 -29.538 -19.391 1.00 32.99 ? 1073 HOH B O 1 HETATM 4691 O O . HOH S 7 . ? 57.346 -41.668 -13.048 1.00 15.17 ? 805 HOH B O 1 HETATM 4692 O O . HOH S 7 . ? 54.716 -16.682 -15.363 1.00 30.07 ? 1075 HOH B O 1 HETATM 4693 O O . HOH S 7 . ? 46.266 -50.347 21.005 1.00 45.65 ? 1076 HOH B O 1 HETATM 4694 O O . HOH S 7 . ? 50.352 -30.689 16.930 1.00 34.99 ? 1077 HOH B O 1 HETATM 4695 O O . HOH S 7 . ? 50.086 -20.722 -3.931 1.00 22.68 ? 1078 HOH B O 1 HETATM 4696 O O . HOH S 7 . ? 64.500 -21.748 -17.663 1.00 25.57 ? 1079 HOH B O 1 HETATM 4697 O O . HOH S 7 . ? 65.598 -16.828 -13.081 1.00 40.19 ? 1080 HOH B O 1 HETATM 4698 O O . HOH S 7 . ? 43.700 -34.217 -16.243 1.00 28.88 ? 1081 HOH B O 1 HETATM 4699 O O . HOH S 7 . ? 40.350 -47.953 6.714 1.00 21.36 ? 1082 HOH B O 1 HETATM 4700 O O . HOH S 7 . ? 62.939 -24.502 -2.203 1.00 22.50 ? 1083 HOH B O 1 HETATM 4701 O O . HOH S 7 . ? 59.208 -52.091 -14.206 1.00 20.71 ? 1084 HOH B O 1 HETATM 4702 O O . HOH S 7 . ? 63.681 -28.377 -20.443 1.00 28.98 ? 1085 HOH B O 1 HETATM 4703 O O . HOH S 7 . ? 44.095 -45.960 -14.342 1.00 14.25 ? 1086 HOH B O 1 HETATM 4704 O O . HOH S 7 . ? 60.492 -45.957 3.715 1.00 11.45 ? 1087 HOH B O 1 HETATM 4705 O O . HOH S 7 . ? 53.426 -19.674 -0.939 0.50 9.03 ? 1088 HOH B O 1 HETATM 4706 O O . HOH S 7 . ? 55.134 -19.596 -0.383 0.50 19.38 ? 1089 HOH B O 1 HETATM 4707 O O . HOH S 7 . ? 53.429 -44.183 -8.586 1.00 12.34 ? 1090 HOH B O 1 HETATM 4708 O O . HOH S 7 . ? 64.863 -41.054 -6.815 1.00 22.05 ? 1091 HOH B O 1 HETATM 4709 O O . HOH S 7 . ? 53.508 -54.444 -16.800 1.00 25.82 ? 1092 HOH B O 1 HETATM 4710 O O . HOH S 7 . ? 60.510 -30.228 -25.848 1.00 37.53 ? 1093 HOH B O 1 HETATM 4711 O O . HOH S 7 . ? 64.754 -27.209 -1.984 1.00 30.85 ? 1094 HOH B O 1 HETATM 4712 O O . HOH S 7 . ? 64.415 -37.680 -8.812 1.00 21.89 ? 1095 HOH B O 1 HETATM 4713 O O . HOH S 7 . ? 50.205 -34.398 17.178 1.00 44.36 ? 1096 HOH B O 1 HETATM 4714 O O . HOH S 7 . ? 49.698 -26.921 -22.950 1.00 36.55 ? 1097 HOH B O 1 HETATM 4715 O O . HOH S 7 . ? 57.391 -29.402 14.793 1.00 19.18 ? 1098 HOH B O 1 HETATM 4716 O O . HOH S 7 . ? 72.081 -26.474 -9.967 1.00 34.23 ? 1099 HOH B O 1 HETATM 4717 O O . HOH S 7 . ? 49.456 -43.593 -24.997 0.50 24.30 ? 1100 HOH B O 1 HETATM 4718 O O . HOH S 7 . ? 65.862 -30.908 -20.574 1.00 24.47 ? 1101 HOH B O 1 HETATM 4719 O O . HOH S 7 . ? 47.333 -40.524 -23.114 1.00 23.69 ? 1102 HOH B O 1 HETATM 4720 O O . HOH S 7 . ? 53.064 -57.682 -6.806 1.00 22.78 ? 1103 HOH B O 1 HETATM 4721 O O . HOH S 7 . ? 55.617 -41.158 2.730 1.00 14.38 ? 1104 HOH B O 1 HETATM 4722 O O . HOH S 7 . ? 51.061 -36.510 13.595 1.00 23.56 ? 1105 HOH B O 1 HETATM 4723 O O . HOH S 7 . ? 57.931 -38.492 21.493 1.00 37.42 ? 1106 HOH B O 1 HETATM 4724 O O . HOH S 7 . ? 51.446 -21.344 -21.274 1.00 39.47 ? 1107 HOH B O 1 HETATM 4725 O O . HOH S 7 . ? 74.500 -46.899 -0.197 1.00 34.39 ? 1108 HOH B O 1 HETATM 4726 O O . HOH S 7 . ? 47.119 -53.454 18.001 1.00 38.09 ? 1109 HOH B O 1 HETATM 4727 O O . HOH S 7 . ? 52.680 -62.373 1.267 1.00 53.91 ? 1110 HOH B O 1 HETATM 4728 O O . HOH S 7 . ? 66.437 -30.949 1.861 0.50 12.09 ? 1111 HOH B O 1 HETATM 4729 O O . HOH S 7 . ? 69.536 -55.145 -5.344 1.00 24.65 ? 1112 HOH B O 1 HETATM 4730 O O . HOH S 7 . ? 44.646 -39.332 -26.053 1.00 48.62 ? 1113 HOH B O 1 HETATM 4731 O O . HOH S 7 . ? 61.520 -26.130 13.128 1.00 33.97 ? 1114 HOH B O 1 HETATM 4732 O O . HOH S 7 . ? 64.233 -44.130 -14.254 1.00 39.38 ? 1115 HOH B O 1 HETATM 4733 O O . HOH S 7 . ? 60.046 -57.883 10.517 1.00 30.95 ? 1116 HOH B O 1 HETATM 4734 O O . HOH S 7 . ? 57.547 -24.688 10.711 1.00 25.01 ? 1117 HOH B O 1 HETATM 4735 O O . HOH S 7 . ? 45.078 -58.363 -0.328 1.00 28.74 ? 1118 HOH B O 1 HETATM 4736 O O . HOH S 7 . ? 63.198 -42.676 7.176 1.00 17.50 ? 1119 HOH B O 1 HETATM 4737 O O . HOH S 7 . ? 52.593 -31.613 -25.617 1.00 32.70 ? 1120 HOH B O 1 HETATM 4738 O O . HOH S 7 . ? 55.739 -17.217 -6.323 1.00 24.01 ? 1121 HOH B O 1 HETATM 4739 O O . HOH S 7 . ? 60.007 -28.744 -30.516 1.00 29.76 ? 1122 HOH B O 1 HETATM 4740 O O . HOH S 7 . ? 47.793 -57.893 9.479 1.00 25.95 ? 1123 HOH B O 1 HETATM 4741 O O . HOH S 7 . ? 35.466 -41.008 -4.448 1.00 23.03 ? 1124 HOH B O 1 HETATM 4742 O O . HOH S 7 . ? 43.379 -33.241 -12.128 1.00 19.72 ? 1125 HOH B O 1 HETATM 4743 O O . HOH S 7 . ? 60.099 -32.752 0.053 1.00 11.99 ? 1126 HOH B O 1 HETATM 4744 O O . HOH S 7 . ? 43.902 -59.231 -4.989 1.00 38.24 ? 1127 HOH B O 1 HETATM 4745 O O . HOH S 7 . ? 62.622 -39.469 8.500 1.00 25.20 ? 1128 HOH B O 1 HETATM 4746 O O . HOH S 7 . ? 58.597 -48.985 -12.292 1.00 12.41 ? 1129 HOH B O 1 HETATM 4747 O O . HOH S 7 . ? 45.501 -40.937 15.630 1.00 53.33 ? 1130 HOH B O 1 HETATM 4748 O O . HOH S 7 . ? 64.095 -49.485 11.135 1.00 51.84 ? 1131 HOH B O 1 HETATM 4749 O O . HOH S 7 . ? 43.820 -31.973 -24.541 1.00 23.08 ? 1132 HOH B O 1 HETATM 4750 O O . HOH S 7 . ? 54.128 -63.353 3.682 1.00 48.44 ? 1133 HOH B O 1 HETATM 4751 O O . HOH S 7 . ? 56.812 -57.868 13.204 1.00 41.67 ? 1134 HOH B O 1 HETATM 4752 O O . HOH S 7 . ? 56.548 -19.361 -13.112 1.00 20.75 ? 1135 HOH B O 1 HETATM 4753 O O . HOH S 7 . ? 54.301 -51.651 -22.479 1.00 32.57 ? 1136 HOH B O 1 HETATM 4754 O O . HOH S 7 . ? 63.564 -37.289 -4.228 1.00 28.72 ? 1137 HOH B O 1 HETATM 4755 O O . HOH S 7 . ? 38.773 -50.682 -5.942 1.00 35.18 ? 1138 HOH B O 1 HETATM 4756 O O . HOH S 7 . ? 61.840 -29.051 -22.891 1.00 39.69 ? 1139 HOH B O 1 HETATM 4757 O O . HOH S 7 . ? 47.450 -32.118 14.471 1.00 24.73 ? 1140 HOH B O 1 HETATM 4758 O O . HOH S 7 . ? 56.915 -48.292 -14.461 1.00 16.38 ? 1141 HOH B O 1 HETATM 4759 O O . HOH S 7 . ? 57.030 -62.738 5.081 1.00 49.89 ? 1142 HOH B O 1 HETATM 4760 O O . HOH S 7 . ? 53.444 -21.291 2.517 1.00 43.87 ? 1143 HOH B O 1 HETATM 4761 O O . HOH S 7 . ? 45.478 -56.804 -6.080 1.00 24.35 ? 1144 HOH B O 1 HETATM 4762 O O . HOH S 7 . ? 40.384 -44.345 -2.569 1.00 19.92 ? 1145 HOH B O 1 HETATM 4763 O O . HOH S 7 . ? 51.132 -28.592 -24.317 1.00 24.40 ? 1146 HOH B O 1 HETATM 4764 O O . HOH S 7 . ? 43.464 -56.320 -9.378 0.50 16.06 ? 1147 HOH B O 1 HETATM 4765 O O . HOH S 7 . ? 43.671 -46.995 -18.113 1.00 20.24 ? 1148 HOH B O 1 HETATM 4766 O O . HOH S 7 . ? 44.728 -25.595 8.491 1.00 22.56 ? 1149 HOH B O 1 HETATM 4767 O O . HOH S 7 . ? 64.335 -26.633 7.703 1.00 21.91 ? 1150 HOH B O 1 HETATM 4768 O O . HOH S 7 . ? 68.124 -56.076 2.534 1.00 45.08 ? 1151 HOH B O 1 HETATM 4769 O O . HOH S 7 . ? 65.325 -25.206 -19.236 1.00 39.59 ? 1152 HOH B O 1 HETATM 4770 O O . HOH S 7 . ? 44.028 -27.132 -15.830 1.00 31.71 ? 1153 HOH B O 1 HETATM 4771 O O . HOH S 7 . ? 67.469 -27.273 -6.794 1.00 41.18 ? 1154 HOH B O 1 HETATM 4772 O O . HOH S 7 . ? 47.514 -23.821 -1.127 1.00 18.05 ? 1155 HOH B O 1 HETATM 4773 O O . HOH S 7 . ? 61.127 -43.047 -19.031 1.00 28.60 ? 1156 HOH B O 1 HETATM 4774 O O . HOH S 7 . ? 52.691 -28.024 14.374 1.00 34.57 ? 1157 HOH B O 1 HETATM 4775 O O . HOH S 7 . ? 67.031 -28.995 1.179 0.50 19.45 ? 1158 HOH B O 1 HETATM 4776 O O . HOH S 7 . ? 60.344 -39.637 -22.708 1.00 28.14 ? 1159 HOH B O 1 HETATM 4777 O O . HOH S 7 . ? 65.103 -36.273 -21.223 1.00 25.25 ? 1160 HOH B O 1 HETATM 4778 O O . HOH S 7 . ? 35.083 -25.604 6.437 1.00 35.87 ? 1161 HOH B O 1 HETATM 4779 O O . HOH S 7 . ? 57.043 -61.100 7.413 1.00 29.27 ? 1162 HOH B O 1 HETATM 4780 O O . HOH S 7 . ? 35.491 -28.399 2.805 0.50 22.45 ? 1163 HOH B O 1 HETATM 4781 O O . HOH S 7 . ? 38.090 -38.383 9.130 1.00 30.51 ? 1164 HOH B O 1 HETATM 4782 O O . HOH S 7 . ? 54.350 -32.197 -22.778 1.00 29.15 ? 1165 HOH B O 1 HETATM 4783 O O . HOH S 7 . ? 38.609 -53.104 2.328 1.00 22.96 ? 1166 HOH B O 1 HETATM 4784 O O . HOH S 7 . ? 45.045 -50.706 -15.487 1.00 21.14 ? 1167 HOH B O 1 HETATM 4785 O O . HOH S 7 . ? 67.046 -51.390 -10.231 1.00 47.92 ? 1168 HOH B O 1 HETATM 4786 O O . HOH S 7 . ? 53.147 -63.472 11.206 1.00 34.72 ? 1169 HOH B O 1 HETATM 4787 O O . HOH S 7 . ? 41.836 -42.107 7.042 1.00 28.46 ? 1170 HOH B O 1 HETATM 4788 O O . HOH S 7 . ? 59.296 -54.128 -18.818 1.00 36.34 ? 1171 HOH B O 1 HETATM 4789 O O . HOH S 7 . ? 61.420 -16.205 -15.854 1.00 28.16 ? 1172 HOH B O 1 HETATM 4790 O O . HOH S 7 . ? 56.069 -41.676 -22.547 1.00 27.52 ? 1173 HOH B O 1 HETATM 4791 O O . HOH S 7 . ? 39.256 -33.757 -3.329 0.50 21.51 ? 1174 HOH B O 1 HETATM 4792 O O . HOH S 7 . ? 69.344 -43.662 -10.038 1.00 41.69 ? 1175 HOH B O 1 HETATM 4793 O O . HOH S 7 . ? 54.926 -25.780 -25.420 1.00 23.54 ? 1176 HOH B O 1 HETATM 4794 O O . HOH S 7 . ? 53.853 -29.385 -23.665 1.00 27.21 ? 1177 HOH B O 1 HETATM 4795 O O . HOH S 7 . ? 61.842 -48.456 12.673 1.00 28.75 ? 1178 HOH B O 1 HETATM 4796 O O . HOH S 7 . ? 53.171 -55.157 -20.987 1.00 51.07 ? 1179 HOH B O 1 HETATM 4797 O O . HOH S 7 . ? 36.516 -40.799 4.708 1.00 50.79 ? 1180 HOH B O 1 HETATM 4798 O O . HOH S 7 . ? 62.624 -44.114 -16.319 1.00 45.78 ? 1181 HOH B O 1 HETATM 4799 O O . HOH S 7 . ? 64.843 -34.553 -4.797 1.00 44.16 ? 1182 HOH B O 1 HETATM 4800 O O . HOH S 7 . ? 73.042 -55.033 -6.391 1.00 43.73 ? 1183 HOH B O 1 HETATM 4801 O O . HOH S 7 . ? 49.980 -53.645 -22.474 1.00 32.99 ? 1184 HOH B O 1 HETATM 4802 O O . HOH S 7 . ? 67.272 -36.459 -11.037 1.00 46.25 ? 1185 HOH B O 1 HETATM 4803 O O . HOH S 7 . ? 62.066 -19.756 -4.511 1.00 43.70 ? 1186 HOH B O 1 HETATM 4804 O O . HOH S 7 . ? 66.073 -42.973 5.909 1.00 33.22 ? 1187 HOH B O 1 HETATM 4805 O O . HOH S 7 . ? 53.392 -61.010 -1.074 1.00 44.60 ? 1188 HOH B O 1 HETATM 4806 O O . HOH S 7 . ? 57.561 -49.633 -17.420 1.00 36.39 ? 1189 HOH B O 1 HETATM 4807 O O . HOH S 7 . ? 46.621 -59.509 -4.241 1.00 21.32 ? 1190 HOH B O 1 HETATM 4808 O O . HOH S 7 . ? 33.651 -47.442 -1.440 1.00 43.86 ? 1191 HOH B O 1 HETATM 4809 O O . HOH S 7 . ? 52.387 -41.355 18.557 1.00 38.70 ? 1192 HOH B O 1 HETATM 4810 O O . HOH S 7 . ? 59.107 -56.593 12.720 1.00 39.72 ? 1193 HOH B O 1 HETATM 4811 O O . HOH S 7 . ? 58.866 -53.911 19.039 1.00 49.80 ? 1194 HOH B O 1 HETATM 4812 O O . HOH S 7 . ? 33.633 -41.910 4.135 1.00 52.55 ? 1195 HOH B O 1 HETATM 4813 O O . HOH S 7 . ? 65.696 -35.117 -9.444 1.00 47.12 ? 1196 HOH B O 1 HETATM 4814 O O . HOH S 7 . ? 43.610 -36.360 -19.363 1.00 39.14 ? 1197 HOH B O 1 HETATM 4815 O O . HOH S 7 . ? 66.871 -23.215 -6.289 1.00 52.47 ? 1198 HOH B O 1 HETATM 4816 O O . HOH S 7 . ? 47.404 -25.134 -13.854 1.00 33.64 ? 1199 HOH B O 1 HETATM 4817 O O . HOH S 7 . ? 56.316 -51.366 -19.223 1.00 34.66 ? 1200 HOH B O 1 HETATM 4818 O O . HOH S 7 . ? 65.266 -33.632 10.370 1.00 35.94 ? 1201 HOH B O 1 HETATM 4819 O O . HOH S 7 . ? 38.513 -53.465 -5.611 1.00 30.36 ? 1202 HOH B O 1 HETATM 4820 O O . HOH S 7 . ? 53.131 -36.957 -26.083 1.00 35.18 ? 1203 HOH B O 1 HETATM 4821 O O . HOH S 7 . ? 59.715 -57.067 -8.825 1.00 42.17 ? 1204 HOH B O 1 HETATM 4822 O O . HOH S 7 . ? 68.989 -30.437 -14.628 1.00 36.08 ? 1205 HOH B O 1 HETATM 4823 O O . HOH S 7 . ? 64.783 -34.089 0.171 1.00 22.02 ? 1206 HOH B O 1 HETATM 4824 O O . HOH S 7 . ? 63.746 -31.086 13.084 1.00 26.12 ? 1207 HOH B O 1 HETATM 4825 O O . HOH S 7 . ? 41.135 -45.208 18.073 1.00 45.09 ? 1208 HOH B O 1 HETATM 4826 O O . HOH S 7 . ? 56.127 -16.127 -12.942 1.00 24.33 ? 1209 HOH B O 1 HETATM 4827 O O . HOH S 7 . ? 59.713 -33.507 14.486 1.00 22.47 ? 1210 HOH B O 1 HETATM 4828 O O . HOH S 7 . ? 59.619 -64.906 9.064 1.00 50.75 ? 1211 HOH B O 1 HETATM 4829 O O . HOH S 7 . ? 49.549 -42.257 21.637 1.00 45.40 ? 1212 HOH B O 1 HETATM 4830 O O . HOH S 7 . ? 51.347 -60.514 -3.385 1.00 36.16 ? 1213 HOH B O 1 HETATM 4831 O O . HOH S 7 . ? 79.683 -53.450 -3.437 1.00 40.05 ? 1214 HOH B O 1 HETATM 4832 O O . HOH S 7 . ? 62.652 -23.935 2.388 1.00 41.36 ? 1215 HOH B O 1 HETATM 4833 O O . HOH S 7 . ? 51.629 -57.998 14.242 1.00 44.73 ? 1216 HOH B O 1 HETATM 4834 O O . HOH S 7 . ? 65.384 -59.023 -1.521 1.00 56.54 ? 1217 HOH B O 1 HETATM 4835 O O . HOH S 7 . ? 53.409 -42.547 20.662 1.00 47.49 ? 1218 HOH B O 1 HETATM 4836 O O . HOH S 7 . ? 42.876 -38.604 -21.309 1.00 24.10 ? 1219 HOH B O 1 HETATM 4837 O O . HOH S 7 . ? 61.653 -41.425 -20.626 1.00 34.02 ? 1220 HOH B O 1 HETATM 4838 O O . HOH S 7 . ? 64.651 -23.929 -4.330 1.00 27.10 ? 1221 HOH B O 1 HETATM 4839 O O . HOH S 7 . ? 30.840 -34.180 2.201 1.00 51.35 ? 1222 HOH B O 1 HETATM 4840 O O . HOH S 7 . ? 52.354 -21.070 -14.360 1.00 28.61 ? 1223 HOH B O 1 HETATM 4841 O O . HOH S 7 . ? 51.102 -38.134 15.749 0.50 9.55 ? 1224 HOH B O 1 HETATM 4842 O O . HOH S 7 . ? 67.177 -54.425 5.258 1.00 38.52 ? 1225 HOH B O 1 HETATM 4843 O O . HOH S 7 . ? 60.702 -22.076 -25.197 1.00 39.65 ? 1226 HOH B O 1 HETATM 4844 O O . HOH S 7 . ? 53.442 -42.248 -25.062 0.50 17.59 ? 1227 HOH B O 1 HETATM 4845 O O . HOH S 7 . ? 67.945 -32.285 -3.002 1.00 51.71 ? 1228 HOH B O 1 HETATM 4846 O O . HOH S 7 . ? 47.141 -43.565 -21.727 1.00 15.28 ? 1229 HOH B O 1 HETATM 4847 O O . HOH S 7 . ? 63.325 -57.298 -15.411 1.00 48.67 ? 1230 HOH B O 1 HETATM 4848 O O . HOH S 7 . ? 62.651 -27.224 -31.558 1.00 25.58 ? 1231 HOH B O 1 HETATM 4849 O O . HOH S 7 . ? 66.124 -32.825 3.000 0.50 25.29 ? 1232 HOH B O 1 HETATM 4850 O O . HOH S 7 . ? 58.437 -47.320 -19.997 1.00 49.07 ? 1233 HOH B O 1 HETATM 4851 O O . HOH S 7 . ? 68.564 -36.872 -13.071 1.00 44.84 ? 1234 HOH B O 1 HETATM 4852 O O . HOH S 7 . ? 65.918 -21.114 -20.159 1.00 52.16 ? 1235 HOH B O 1 HETATM 4853 O O . HOH S 7 . ? 55.096 -56.720 -12.702 1.00 36.30 ? 1236 HOH B O 1 HETATM 4854 O O . HOH S 7 . ? 47.074 -59.326 11.253 1.00 38.83 ? 1237 HOH B O 1 HETATM 4855 O O . HOH S 7 . ? 67.504 -35.442 -20.248 1.00 18.81 ? 1238 HOH B O 1 HETATM 4856 O O . HOH S 7 . ? 50.601 -55.711 17.416 1.00 47.68 ? 1239 HOH B O 1 HETATM 4857 O O . HOH S 7 . ? 42.310 -40.817 15.139 1.00 49.12 ? 1240 HOH B O 1 HETATM 4858 O O . HOH S 7 . ? 51.118 -39.929 16.692 0.50 20.18 ? 1241 HOH B O 1 HETATM 4859 O O . HOH S 7 . ? 35.727 -51.128 -4.021 1.00 52.51 ? 1242 HOH B O 1 HETATM 4860 O O . HOH S 7 . ? 64.170 -35.221 -7.340 1.00 22.94 ? 1243 HOH B O 1 HETATM 4861 O O . HOH S 7 . ? 37.428 -50.389 3.089 1.00 50.62 ? 1244 HOH B O 1 HETATM 4862 O O . HOH S 7 . ? 65.307 -44.279 -9.293 1.00 30.21 ? 1245 HOH B O 1 HETATM 4863 O O . HOH S 7 . ? 64.882 -38.208 -19.400 1.00 23.47 ? 1246 HOH B O 1 HETATM 4864 O O . HOH S 7 . ? 53.420 -59.743 -5.031 1.00 39.21 ? 1247 HOH B O 1 HETATM 4865 O O . HOH S 7 . ? 51.801 -19.830 1.502 1.00 26.44 ? 1248 HOH B O 1 HETATM 4866 O O . HOH S 7 . ? 38.230 -36.000 9.994 1.00 25.67 ? 1249 HOH B O 1 HETATM 4867 O O . HOH S 7 . ? 43.740 -31.846 -17.710 1.00 28.88 ? 1250 HOH B O 1 HETATM 4868 O O . HOH S 7 . ? 63.434 -32.036 -24.350 1.00 44.88 ? 1251 HOH B O 1 HETATM 4869 O O . HOH S 7 . ? 66.779 -38.628 -17.445 1.00 31.48 ? 1252 HOH B O 1 HETATM 4870 O O . HOH S 7 . ? 55.022 -14.866 -8.701 1.00 42.81 ? 1253 HOH B O 1 HETATM 4871 O O . HOH S 7 . ? 65.235 -59.262 -4.569 1.00 48.49 ? 1254 HOH B O 1 HETATM 4872 O O . HOH S 7 . ? 55.498 -57.016 -17.192 1.00 48.66 ? 1255 HOH B O 1 HETATM 4873 O O . HOH S 7 . ? 54.082 -41.710 -27.222 0.50 28.42 ? 1256 HOH B O 1 HETATM 4874 O O . HOH S 7 . ? 44.399 -27.064 -18.417 1.00 45.22 ? 1257 HOH B O 1 HETATM 4875 O O . HOH S 7 . ? 69.246 -49.414 4.379 1.00 36.06 ? 1258 HOH B O 1 HETATM 4876 O O . HOH S 7 . ? 56.239 -17.046 -3.632 1.00 36.04 ? 1259 HOH B O 1 HETATM 4877 O O . HOH S 7 . ? 60.317 -35.706 -25.320 0.50 25.35 ? 1260 HOH B O 1 HETATM 4878 O O . HOH S 7 . ? 56.385 -19.388 -23.055 1.00 40.08 ? 1261 HOH B O 1 HETATM 4879 O O . HOH S 7 . ? 43.754 -28.348 -10.841 1.00 47.12 ? 1262 HOH B O 1 HETATM 4880 O O . HOH S 7 . ? 68.680 -57.838 -4.796 1.00 49.10 ? 1263 HOH B O 1 HETATM 4881 O O . HOH S 7 . ? 51.746 -56.073 -14.672 1.00 45.17 ? 1264 HOH B O 1 HETATM 4882 O O . HOH S 7 . ? 54.492 -20.919 -24.207 1.00 37.03 ? 1265 HOH B O 1 HETATM 4883 O O . HOH S 7 . ? 64.746 -48.049 -11.740 1.00 37.43 ? 1266 HOH B O 1 HETATM 4884 O O . HOH S 7 . ? 64.605 -56.132 8.343 1.00 45.10 ? 1267 HOH B O 1 HETATM 4885 O O . HOH S 7 . ? 43.820 -28.330 -5.958 1.00 53.68 ? 1268 HOH B O 1 HETATM 4886 O O . HOH S 7 . ? 54.826 -58.349 -8.496 1.00 50.00 ? 1269 HOH B O 1 HETATM 4887 O O . HOH S 7 . ? 64.434 -40.466 -20.542 1.00 31.24 ? 1270 HOH B O 1 HETATM 4888 O O . HOH S 7 . ? 66.813 -28.549 -3.492 1.00 38.38 ? 1271 HOH B O 1 HETATM 4889 O O . HOH S 7 . ? 45.305 -24.716 -19.859 1.00 47.43 ? 1272 HOH B O 1 HETATM 4890 O O . HOH S 7 . ? 31.377 -38.183 -0.396 1.00 42.04 ? 1273 HOH B O 1 HETATM 4891 O O . HOH S 7 . ? 64.965 -37.480 -1.838 1.00 50.44 ? 1274 HOH B O 1 HETATM 4892 O O . HOH S 7 . ? 58.890 -25.611 12.642 1.00 41.47 ? 1275 HOH B O 1 HETATM 4893 O O . HOH S 7 . ? 53.799 -17.471 -2.316 1.00 45.13 ? 1276 HOH B O 1 HETATM 4894 O O . HOH S 7 . ? 65.111 -45.511 -11.648 1.00 42.36 ? 1277 HOH B O 1 HETATM 4895 O O . HOH S 7 . ? 65.508 -53.641 -11.317 1.00 42.35 ? 1278 HOH B O 1 HETATM 4896 O O . HOH S 7 . ? 38.267 -23.108 8.950 0.50 20.41 ? 1279 HOH B O 1 HETATM 4897 O O . HOH S 7 . ? 62.998 -22.656 -0.289 1.00 35.50 ? 1280 HOH B O 1 HETATM 4898 O O . HOH S 7 . ? 64.454 -46.060 11.643 1.00 39.92 ? 1281 HOH B O 1 HETATM 4899 O O . HOH S 7 . ? 45.616 -58.065 -9.148 1.00 44.27 ? 1282 HOH B O 1 HETATM 4900 O O . HOH S 7 . ? 54.890 -43.169 -24.082 0.50 21.30 ? 1283 HOH B O 1 HETATM 4901 O O . HOH S 7 . ? 67.506 -24.752 -17.790 1.00 46.08 ? 1284 HOH B O 1 HETATM 4902 O O . HOH S 7 . ? 39.296 -49.923 8.517 1.00 41.00 ? 1285 HOH B O 1 HETATM 4903 O O . HOH S 7 . ? 50.092 -19.941 -14.210 1.00 49.83 ? 1286 HOH B O 1 HETATM 4904 O O . HOH S 7 . ? 64.371 -58.952 -7.201 1.00 55.25 ? 1287 HOH B O 1 HETATM 4905 O O . HOH S 7 . ? 55.655 -34.051 -24.559 1.00 28.25 ? 1288 HOH B O 1 HETATM 4906 O O . HOH S 7 . ? 62.359 -33.078 15.318 1.00 35.90 ? 1289 HOH B O 1 HETATM 4907 O O . HOH S 7 . ? 56.711 -14.733 -6.910 1.00 50.85 ? 1290 HOH B O 1 HETATM 4908 O O . HOH S 7 . ? 69.345 -34.525 -16.844 1.00 32.59 ? 1291 HOH B O 1 HETATM 4909 O O . HOH S 7 . ? 59.008 -14.778 -8.555 1.00 58.59 ? 1292 HOH B O 1 HETATM 4910 O O . HOH S 7 . ? 40.601 -49.976 12.771 1.00 54.01 ? 1293 HOH B O 1 HETATM 4911 O O . HOH S 7 . ? 41.667 -33.746 -14.818 1.00 46.76 ? 1294 HOH B O 1 HETATM 4912 O O . HOH S 7 . ? 60.597 -49.267 -14.247 1.00 26.56 ? 1295 HOH B O 1 HETATM 4913 O O . HOH S 7 . ? 60.034 -15.203 -10.826 1.00 53.30 ? 1296 HOH B O 1 HETATM 4914 O O . HOH S 7 . ? 58.252 -40.461 -24.218 1.00 36.40 ? 1297 HOH B O 1 HETATM 4915 O O . HOH S 7 . ? 39.541 -43.424 7.155 1.00 34.90 ? 1298 HOH B O 1 HETATM 4916 O O . HOH S 7 . ? 44.318 -53.740 -14.316 1.00 53.04 ? 1299 HOH B O 1 HETATM 4917 O O . HOH S 7 . ? 54.914 -28.882 15.964 1.00 29.79 ? 1300 HOH B O 1 HETATM 4918 O O . HOH S 7 . ? 63.523 -14.769 -13.964 1.00 53.02 ? 1301 HOH B O 1 HETATM 4919 O O . HOH S 7 . ? 45.291 -53.066 20.226 1.00 52.35 ? 1302 HOH B O 1 HETATM 4920 O O . HOH S 7 . ? 36.154 -22.785 10.667 0.50 27.18 ? 1303 HOH B O 1 HETATM 4921 O O . HOH S 7 . ? 59.046 -15.029 -15.491 1.00 50.39 ? 1304 HOH B O 1 HETATM 4922 O O . HOH S 7 . ? 44.225 -25.816 -7.547 1.00 35.71 ? 1305 HOH B O 1 HETATM 4923 O O . HOH S 7 . ? 38.697 -47.735 4.511 1.00 47.31 ? 1306 HOH B O 1 HETATM 4924 O O . HOH S 7 . ? 55.923 -15.275 -17.639 1.00 49.67 ? 1307 HOH B O 1 HETATM 4925 O O . HOH S 7 . ? 48.896 -58.685 14.451 1.00 47.69 ? 1308 HOH B O 1 HETATM 4926 O O . HOH S 7 . ? 68.770 -30.293 2.269 1.00 45.11 ? 1309 HOH B O 1 HETATM 4927 O O . HOH S 7 . ? 63.337 -48.833 -14.010 0.50 21.34 ? 1310 HOH B O 1 HETATM 4928 O O . HOH S 7 . ? 37.882 -54.710 4.792 1.00 50.96 ? 1311 HOH B O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 TRP 1 21 21 TRP TRP A . n A 1 2 GLY 2 22 22 GLY GLY A . n A 1 3 ASN 3 23 23 ASN ASN A . n A 1 4 LEU 4 24 24 LEU LEU A . n A 1 5 GLY 5 25 25 GLY GLY A . n A 1 6 HIS 6 26 26 HIS HIS A . n A 1 7 GLU 7 27 27 GLU GLU A . n A 1 8 THR 8 28 28 THR THR A . n A 1 9 VAL 9 29 29 VAL VAL A . n A 1 10 ALA 10 30 30 ALA ALA A . n A 1 11 TYR 11 31 31 TYR TYR A . n A 1 12 ILE 12 32 32 ILE ILE A . n A 1 13 ALA 13 33 33 ALA ALA A . n A 1 14 GLN 14 34 34 GLN GLN A . n A 1 15 SER 15 35 35 SER SER A . n A 1 16 PHE 16 36 36 PHE PHE A . n A 1 17 VAL 17 37 37 VAL VAL A . n A 1 18 ALA 18 38 38 ALA ALA A . n A 1 19 SER 19 39 39 SER SER A . n A 1 20 SER 20 40 40 SER SER A . n A 1 21 THR 21 41 41 THR THR A . n A 1 22 GLU 22 42 42 GLU GLU A . n A 1 23 SER 23 43 43 SER SER A . n A 1 24 PHE 24 44 44 PHE PHE A . n A 1 25 CYS 25 45 45 CYS CYS A . n A 1 26 GLN 26 46 46 GLN GLN A . n A 1 27 ASN 27 47 47 ASN ASN A . n A 1 28 ILE 28 48 48 ILE ILE A . n A 1 29 LEU 29 49 49 LEU LEU A . n A 1 30 GLY 30 50 50 GLY GLY A . n A 1 31 ASP 31 51 51 ASP ASP A . n A 1 32 ASP 32 52 52 ASP ASP A . n A 1 33 SER 33 53 53 SER SER A . n A 1 34 THR 34 54 54 THR THR A . n A 1 35 SER 35 55 55 SER SER A . n A 1 36 TYR 36 56 56 TYR TYR A . n A 1 37 LEU 37 57 57 LEU LEU A . n A 1 38 ALA 38 58 58 ALA ALA A . n A 1 39 ASN 39 59 59 ASN ASN A . n A 1 40 VAL 40 60 60 VAL VAL A . n A 1 41 ALA 41 61 61 ALA ALA A . n A 1 42 THR 42 62 62 THR THR A . n A 1 43 TRP 43 63 63 TRP TRP A . n A 1 44 ALA 44 64 64 ALA ALA A . n A 1 45 ASN 45 65 65 ASN ASN A . n A 1 46 THR 46 66 66 THR THR A . n A 1 47 TYR 47 67 67 TYR TYR A . n A 1 48 LYS 48 68 68 LYS LYS A . n A 1 49 TYR 49 69 69 TYR TYR A . n A 1 50 THR 50 70 70 THR THR A . n A 1 51 ASP 51 71 71 ASP ASP A . n A 1 52 ALA 52 72 72 ALA ALA A . n A 1 53 GLY 53 73 73 GLY GLY A . n A 1 54 GLU 54 74 74 GLU GLU A . n A 1 55 PHE 55 75 75 PHE PHE A . n A 1 56 SER 56 76 76 SER SER A . n A 1 57 LYS 57 77 77 LYS LYS A . n A 1 58 PRO 58 78 78 PRO PRO A . n A 1 59 TYR 59 79 79 TYR TYR A . n A 1 60 HIS 60 80 80 HIS HIS A . n A 1 61 PHE 61 81 81 PHE PHE A . n A 1 62 ILE 62 82 82 ILE ILE A . n A 1 63 ASP 63 83 83 ASP ASP A . n A 1 64 ALA 64 84 84 ALA ALA A . n A 1 65 GLN 65 85 85 GLN GLN A . n A 1 66 ASP 66 86 86 ASP ASP A . n A 1 67 ASN 67 87 87 ASN ASN A . n A 1 68 PRO 68 88 88 PRO PRO A . n A 1 69 PRO 69 89 89 PRO PRO A . n A 1 70 GLN 70 90 90 GLN GLN A . n A 1 71 SER 71 91 91 SER SER A . n A 1 72 CYS 72 92 92 CYS CYS A . n A 1 73 GLY 73 93 93 GLY GLY A . n A 1 74 VAL 74 94 94 VAL VAL A . n A 1 75 ASP 75 95 95 ASP ASP A . n A 1 76 TYR 76 96 96 TYR TYR A . n A 1 77 ASP 77 97 97 ASP ASP A . n A 1 78 ARG 78 98 98 ARG ARG A . n A 1 79 ASP 79 99 99 ASP ASP A . n A 1 80 CYS 80 100 100 CYS CYS A . n A 1 81 GLY 81 101 101 GLY GLY A . n A 1 82 SER 82 102 102 SER SER A . n A 1 83 ALA 83 103 103 ALA ALA A . n A 1 84 GLY 84 104 104 GLY GLY A . n A 1 85 CYS 85 105 105 CYS CYS A . n A 1 86 SER 86 106 106 SER SER A . n A 1 87 ILE 87 107 107 ILE ILE A . n A 1 88 SER 88 108 108 SER SER A . n A 1 89 ALA 89 109 109 ALA ALA A . n A 1 90 ILE 90 110 110 ILE ILE A . n A 1 91 GLN 91 111 111 GLN GLN A . n A 1 92 ASN 92 112 112 ASN ASN A . n A 1 93 TYR 93 113 113 TYR TYR A . n A 1 94 THR 94 114 114 THR THR A . n A 1 95 ASN 95 115 115 ASN ASN A . n A 1 96 ILE 96 116 116 ILE ILE A . n A 1 97 LEU 97 117 117 LEU LEU A . n A 1 98 LEU 98 118 118 LEU LEU A . n A 1 99 GLU 99 119 119 GLU GLU A . n A 1 100 SER 100 120 120 SER SER A . n A 1 101 PRO 101 121 121 PRO PRO A . n A 1 102 ASN 102 122 122 ASN ASN A . n A 1 103 GLY 103 123 123 GLY GLY A . n A 1 104 SER 104 124 124 SER SER A . n A 1 105 GLU 105 125 125 GLU GLU A . n A 1 106 ALA 106 126 126 ALA ALA A . n A 1 107 LEU 107 127 127 LEU LEU A . n A 1 108 ASN 108 128 128 ASN ASN A . n A 1 109 ALA 109 129 129 ALA ALA A . n A 1 110 LEU 110 130 130 LEU LEU A . n A 1 111 LYS 111 131 131 LYS LYS A . n A 1 112 PHE 112 132 132 PHE PHE A . n A 1 113 VAL 113 133 133 VAL VAL A . n A 1 114 VAL 114 134 134 VAL VAL A . n A 1 115 HIS 115 135 135 HIS HIS A . n A 1 116 ILE 116 136 136 ILE ILE A . n A 1 117 ILE 117 137 137 ILE ILE A . n A 1 118 GLY 118 138 138 GLY GLY A . n A 1 119 ASP 119 139 139 ASP ASP A . n A 1 120 ILE 120 140 140 ILE ILE A . n A 1 121 HIS 121 141 141 HIS HIS A . n A 1 122 GLN 122 142 142 GLN GLN A . n A 1 123 PRO 123 143 143 PRO PRO A . n A 1 124 LEU 124 144 144 LEU LEU A . n A 1 125 HIS 125 145 145 HIS HIS A . n A 1 126 ASP 126 146 146 ASP ASP A . n A 1 127 GLU 127 147 147 GLU GLU A . n A 1 128 ASN 128 148 148 ASN ASN A . n A 1 129 LEU 129 149 149 LEU LEU A . n A 1 130 GLU 130 150 150 GLU GLU A . n A 1 131 ALA 131 151 151 ALA ALA A . n A 1 132 GLY 132 152 152 GLY GLY A . n A 1 133 GLY 133 153 153 GLY GLY A . n A 1 134 ASN 134 154 154 ASN ASN A . n A 1 135 GLY 135 155 155 GLY GLY A . n A 1 136 ILE 136 156 156 ILE ILE A . n A 1 137 ASP 137 157 157 ASP ASP A . n A 1 138 VAL 138 158 158 VAL VAL A . n A 1 139 THR 139 159 159 THR THR A . n A 1 140 TYR 140 160 160 TYR TYR A . n A 1 141 ASP 141 161 161 ASP ASP A . n A 1 142 GLY 142 162 162 GLY GLY A . n A 1 143 GLU 143 163 163 GLU GLU A . n A 1 144 THR 144 164 164 THR THR A . n A 1 145 THR 145 165 165 THR THR A . n A 1 146 ASN 146 166 166 ASN ASN A . n A 1 147 LEU 147 167 167 LEU LEU A . n A 1 148 HIS 148 168 168 HIS HIS A . n A 1 149 HIS 149 169 169 HIS HIS A . n A 1 150 ILE 150 170 170 ILE ILE A . n A 1 151 TRP 151 171 171 TRP TRP A . n A 1 152 ASP 152 172 172 ASP ASP A . n A 1 153 THR 153 173 173 THR THR A . n A 1 154 ASN 154 174 174 ASN ASN A . n A 1 155 MET 155 175 175 MET MET A . n A 1 156 PRO 156 176 176 PRO PRO A . n A 1 157 GLU 157 177 177 GLU GLU A . n A 1 158 GLU 158 178 178 GLU GLU A . n A 1 159 ALA 159 179 179 ALA ALA A . n A 1 160 ALA 160 180 180 ALA ALA A . n A 1 161 GLY 161 181 181 GLY GLY A . n A 1 162 GLY 162 182 182 GLY GLY A . n A 1 163 TYR 163 183 183 TYR TYR A . n A 1 164 SER 164 184 184 SER SER A . n A 1 165 LEU 165 185 185 LEU LEU A . n A 1 166 SER 166 186 186 SER SER A . n A 1 167 VAL 167 187 187 VAL VAL A . n A 1 168 ALA 168 188 188 ALA ALA A . n A 1 169 LYS 169 189 189 LYS LYS A . n A 1 170 THR 170 190 190 THR THR A . n A 1 171 TYR 171 191 191 TYR TYR A . n A 1 172 ALA 172 192 192 ALA ALA A . n A 1 173 ASP 173 193 193 ASP ASP A . n A 1 174 LEU 174 194 194 LEU LEU A . n A 1 175 LEU 175 195 195 LEU LEU A . n A 1 176 THR 176 196 196 THR THR A . n A 1 177 GLU 177 197 197 GLU GLU A . n A 1 178 ARG 178 198 198 ARG ARG A . n A 1 179 ILE 179 199 199 ILE ILE A . n A 1 180 LYS 180 200 200 LYS LYS A . n A 1 181 THR 181 201 201 THR THR A . n A 1 182 GLY 182 202 202 GLY GLY A . n A 1 183 THR 183 203 203 THR THR A . n A 1 184 TYR 184 204 204 TYR TYR A . n A 1 185 SER 185 205 205 SER SER A . n A 1 186 SER 186 206 206 SER SER A . n A 1 187 LYS 187 207 207 LYS LYS A . n A 1 188 LYS 188 208 208 LYS LYS A . n A 1 189 ASP 189 209 209 ASP ASP A . n A 1 190 SER 190 210 210 SER SER A . n A 1 191 TRP 191 211 211 TRP TRP A . n A 1 192 THR 192 212 212 THR THR A . n A 1 193 ASP 193 213 213 ASP ASP A . n A 1 194 GLY 194 214 214 GLY GLY A . n A 1 195 ILE 195 215 215 ILE ILE A . n A 1 196 ASP 196 216 216 ASP ASP A . n A 1 197 ILE 197 217 217 ILE ILE A . n A 1 198 LYS 198 218 218 LYS LYS A . n A 1 199 ASP 199 219 219 ASP ASP A . n A 1 200 PRO 200 220 220 PRO PRO A . n A 1 201 VAL 201 221 221 VAL VAL A . n A 1 202 SER 202 222 222 SER SER A . n A 1 203 THR 203 223 223 THR THR A . n A 1 204 SER 204 224 224 SER SER A . n A 1 205 MET 205 225 225 MET MET A . n A 1 206 ILE 206 226 226 ILE ILE A . n A 1 207 TRP 207 227 227 TRP TRP A . n A 1 208 ALA 208 228 228 ALA ALA A . n A 1 209 ALA 209 229 229 ALA ALA A . n A 1 210 ASP 210 230 230 ASP ASP A . n A 1 211 ALA 211 231 231 ALA ALA A . n A 1 212 ASN 212 232 232 ASN ASN A . n A 1 213 THR 213 233 233 THR THR A . n A 1 214 TYR 214 234 234 TYR TYR A . n A 1 215 VAL 215 235 235 VAL VAL A . n A 1 216 CYS 216 236 236 CYS CYS A . n A 1 217 SER 217 237 237 SER SER A . n A 1 218 THR 218 238 238 THR THR A . n A 1 219 VAL 219 239 239 VAL VAL A . n A 1 220 LEU 220 240 240 LEU LEU A . n A 1 221 ASP 221 241 241 ASP ASP A . n A 1 222 ASP 222 242 242 ASP ASP A . n A 1 223 GLY 223 243 243 GLY GLY A . n A 1 224 LEU 224 244 244 LEU LEU A . n A 1 225 ALA 225 245 245 ALA ALA A . n A 1 226 TYR 226 246 246 TYR TYR A . n A 1 227 ILE 227 247 247 ILE ILE A . n A 1 228 ASN 228 248 248 ASN ASN A . n A 1 229 SER 229 249 249 SER SER A . n A 1 230 THR 230 250 250 THR THR A . n A 1 231 ASP 231 251 251 ASP ASP A . n A 1 232 LEU 232 252 252 LEU LEU A . n A 1 233 SER 233 253 253 SER SER A . n A 1 234 GLY 234 254 254 GLY GLY A . n A 1 235 GLU 235 255 255 GLU GLU A . n A 1 236 TYR 236 256 256 TYR TYR A . n A 1 237 TYR 237 257 257 TYR TYR A . n A 1 238 ASP 238 258 258 ASP ASP A . n A 1 239 LYS 239 259 259 LYS LYS A . n A 1 240 SER 240 260 260 SER SER A . n A 1 241 GLN 241 261 261 GLN GLN A . n A 1 242 PRO 242 262 262 PRO PRO A . n A 1 243 VAL 243 263 263 VAL VAL A . n A 1 244 PHE 244 264 264 PHE PHE A . n A 1 245 GLU 245 265 265 GLU GLU A . n A 1 246 GLU 246 266 266 GLU GLU A . n A 1 247 LEU 247 267 267 LEU LEU A . n A 1 248 ILE 248 268 268 ILE ILE A . n A 1 249 ALA 249 269 269 ALA ALA A . n A 1 250 LYS 250 270 270 LYS LYS A . n A 1 251 ALA 251 271 271 ALA ALA A . n A 1 252 GLY 252 272 272 GLY GLY A . n A 1 253 TYR 253 273 273 TYR TYR A . n A 1 254 ARG 254 274 274 ARG ARG A . n A 1 255 LEU 255 275 275 LEU LEU A . n A 1 256 ALA 256 276 276 ALA ALA A . n A 1 257 ALA 257 277 277 ALA ALA A . n A 1 258 TRP 258 278 278 TRP TRP A . n A 1 259 LEU 259 279 279 LEU LEU A . n A 1 260 ASP 260 280 280 ASP ASP A . n A 1 261 LEU 261 281 281 LEU LEU A . n A 1 262 ILE 262 282 282 ILE ILE A . n A 1 263 ALA 263 283 283 ALA ALA A . n A 1 264 SER 264 284 284 SER SER A . n A 1 265 GLN 265 285 285 GLN GLN A . n A 1 266 PRO 266 286 286 PRO PRO A . n A 1 267 SER 267 287 287 SER SER A . n B 1 1 TRP 1 21 21 TRP TRP B . n B 1 2 GLY 2 22 22 GLY GLY B . n B 1 3 ASN 3 23 23 ASN ASN B . n B 1 4 LEU 4 24 24 LEU LEU B . n B 1 5 GLY 5 25 25 GLY GLY B . n B 1 6 HIS 6 26 26 HIS HIS B . n B 1 7 GLU 7 27 27 GLU GLU B . n B 1 8 THR 8 28 28 THR THR B . n B 1 9 VAL 9 29 29 VAL VAL B . n B 1 10 ALA 10 30 30 ALA ALA B . n B 1 11 TYR 11 31 31 TYR TYR B . n B 1 12 ILE 12 32 32 ILE ILE B . n B 1 13 ALA 13 33 33 ALA ALA B . n B 1 14 GLN 14 34 34 GLN GLN B . n B 1 15 SER 15 35 35 SER SER B . n B 1 16 PHE 16 36 36 PHE PHE B . n B 1 17 VAL 17 37 37 VAL VAL B . n B 1 18 ALA 18 38 38 ALA ALA B . n B 1 19 SER 19 39 39 SER SER B . n B 1 20 SER 20 40 40 SER SER B . n B 1 21 THR 21 41 41 THR THR B . n B 1 22 GLU 22 42 42 GLU GLU B . n B 1 23 SER 23 43 43 SER SER B . n B 1 24 PHE 24 44 44 PHE PHE B . n B 1 25 CYS 25 45 45 CYS CYS B . n B 1 26 GLN 26 46 46 GLN GLN B . n B 1 27 ASN 27 47 47 ASN ASN B . n B 1 28 ILE 28 48 48 ILE ILE B . n B 1 29 LEU 29 49 49 LEU LEU B . n B 1 30 GLY 30 50 50 GLY GLY B . n B 1 31 ASP 31 51 51 ASP ASP B . n B 1 32 ASP 32 52 52 ASP ASP B . n B 1 33 SER 33 53 53 SER SER B . n B 1 34 THR 34 54 54 THR THR B . n B 1 35 SER 35 55 55 SER SER B . n B 1 36 TYR 36 56 56 TYR TYR B . n B 1 37 LEU 37 57 57 LEU LEU B . n B 1 38 ALA 38 58 58 ALA ALA B . n B 1 39 ASN 39 59 59 ASN ASN B . n B 1 40 VAL 40 60 60 VAL VAL B . n B 1 41 ALA 41 61 61 ALA ALA B . n B 1 42 THR 42 62 62 THR THR B . n B 1 43 TRP 43 63 63 TRP TRP B . n B 1 44 ALA 44 64 64 ALA ALA B . n B 1 45 ASN 45 65 65 ASN ASN B . n B 1 46 THR 46 66 66 THR THR B . n B 1 47 TYR 47 67 67 TYR TYR B . n B 1 48 LYS 48 68 68 LYS LYS B . n B 1 49 TYR 49 69 69 TYR TYR B . n B 1 50 THR 50 70 70 THR THR B . n B 1 51 ASP 51 71 71 ASP ASP B . n B 1 52 ALA 52 72 72 ALA ALA B . n B 1 53 GLY 53 73 73 GLY GLY B . n B 1 54 GLU 54 74 74 GLU GLU B . n B 1 55 PHE 55 75 75 PHE PHE B . n B 1 56 SER 56 76 76 SER SER B . n B 1 57 LYS 57 77 77 LYS LYS B . n B 1 58 PRO 58 78 78 PRO PRO B . n B 1 59 TYR 59 79 79 TYR TYR B . n B 1 60 HIS 60 80 80 HIS HIS B . n B 1 61 PHE 61 81 81 PHE PHE B . n B 1 62 ILE 62 82 82 ILE ILE B . n B 1 63 ASP 63 83 83 ASP ASP B . n B 1 64 ALA 64 84 84 ALA ALA B . n B 1 65 GLN 65 85 85 GLN GLN B . n B 1 66 ASP 66 86 86 ASP ASP B . n B 1 67 ASN 67 87 87 ASN ASN B . n B 1 68 PRO 68 88 88 PRO PRO B . n B 1 69 PRO 69 89 89 PRO PRO B . n B 1 70 GLN 70 90 90 GLN GLN B . n B 1 71 SER 71 91 91 SER SER B . n B 1 72 CYS 72 92 92 CYS CYS B . n B 1 73 GLY 73 93 93 GLY GLY B . n B 1 74 VAL 74 94 94 VAL VAL B . n B 1 75 ASP 75 95 95 ASP ASP B . n B 1 76 TYR 76 96 96 TYR TYR B . n B 1 77 ASP 77 97 97 ASP ASP B . n B 1 78 ARG 78 98 98 ARG ARG B . n B 1 79 ASP 79 99 99 ASP ASP B . n B 1 80 CYS 80 100 100 CYS CYS B . n B 1 81 GLY 81 101 101 GLY GLY B . n B 1 82 SER 82 102 102 SER SER B . n B 1 83 ALA 83 103 103 ALA ALA B . n B 1 84 GLY 84 104 104 GLY GLY B . n B 1 85 CYS 85 105 105 CYS CYS B . n B 1 86 SER 86 106 106 SER SER B . n B 1 87 ILE 87 107 107 ILE ILE B . n B 1 88 SER 88 108 108 SER SER B . n B 1 89 ALA 89 109 109 ALA ALA B . n B 1 90 ILE 90 110 110 ILE ILE B . n B 1 91 GLN 91 111 111 GLN GLN B . n B 1 92 ASN 92 112 112 ASN ASN B . n B 1 93 TYR 93 113 113 TYR TYR B . n B 1 94 THR 94 114 114 THR THR B . n B 1 95 ASN 95 115 115 ASN ASN B . n B 1 96 ILE 96 116 116 ILE ILE B . n B 1 97 LEU 97 117 117 LEU LEU B . n B 1 98 LEU 98 118 118 LEU LEU B . n B 1 99 GLU 99 119 119 GLU GLU B . n B 1 100 SER 100 120 120 SER SER B . n B 1 101 PRO 101 121 121 PRO PRO B . n B 1 102 ASN 102 122 122 ASN ASN B . n B 1 103 GLY 103 123 123 GLY GLY B . n B 1 104 SER 104 124 124 SER SER B . n B 1 105 GLU 105 125 125 GLU GLU B . n B 1 106 ALA 106 126 126 ALA ALA B . n B 1 107 LEU 107 127 127 LEU LEU B . n B 1 108 ASN 108 128 128 ASN ASN B . n B 1 109 ALA 109 129 129 ALA ALA B . n B 1 110 LEU 110 130 130 LEU LEU B . n B 1 111 LYS 111 131 131 LYS LYS B . n B 1 112 PHE 112 132 132 PHE PHE B . n B 1 113 VAL 113 133 133 VAL VAL B . n B 1 114 VAL 114 134 134 VAL VAL B . n B 1 115 HIS 115 135 135 HIS HIS B . n B 1 116 ILE 116 136 136 ILE ILE B . n B 1 117 ILE 117 137 137 ILE ILE B . n B 1 118 GLY 118 138 138 GLY GLY B . n B 1 119 ASP 119 139 139 ASP ASP B . n B 1 120 ILE 120 140 140 ILE ILE B . n B 1 121 HIS 121 141 141 HIS HIS B . n B 1 122 GLN 122 142 142 GLN GLN B . n B 1 123 PRO 123 143 143 PRO PRO B . n B 1 124 LEU 124 144 144 LEU LEU B . n B 1 125 HIS 125 145 145 HIS HIS B . n B 1 126 ASP 126 146 146 ASP ASP B . n B 1 127 GLU 127 147 147 GLU GLU B . n B 1 128 ASN 128 148 148 ASN ASN B . n B 1 129 LEU 129 149 149 LEU LEU B . n B 1 130 GLU 130 150 150 GLU GLU B . n B 1 131 ALA 131 151 151 ALA ALA B . n B 1 132 GLY 132 152 152 GLY GLY B . n B 1 133 GLY 133 153 153 GLY GLY B . n B 1 134 ASN 134 154 154 ASN ASN B . n B 1 135 GLY 135 155 155 GLY GLY B . n B 1 136 ILE 136 156 156 ILE ILE B . n B 1 137 ASP 137 157 157 ASP ASP B . n B 1 138 VAL 138 158 158 VAL VAL B . n B 1 139 THR 139 159 159 THR THR B . n B 1 140 TYR 140 160 160 TYR TYR B . n B 1 141 ASP 141 161 161 ASP ASP B . n B 1 142 GLY 142 162 162 GLY GLY B . n B 1 143 GLU 143 163 163 GLU GLU B . n B 1 144 THR 144 164 164 THR THR B . n B 1 145 THR 145 165 165 THR THR B . n B 1 146 ASN 146 166 166 ASN ASN B . n B 1 147 LEU 147 167 167 LEU LEU B . n B 1 148 HIS 148 168 168 HIS HIS B . n B 1 149 HIS 149 169 169 HIS HIS B . n B 1 150 ILE 150 170 170 ILE ILE B . n B 1 151 TRP 151 171 171 TRP TRP B . n B 1 152 ASP 152 172 172 ASP ASP B . n B 1 153 THR 153 173 173 THR THR B . n B 1 154 ASN 154 174 174 ASN ASN B . n B 1 155 MET 155 175 175 MET MET B . n B 1 156 PRO 156 176 176 PRO PRO B . n B 1 157 GLU 157 177 177 GLU GLU B . n B 1 158 GLU 158 178 178 GLU GLU B . n B 1 159 ALA 159 179 179 ALA ALA B . n B 1 160 ALA 160 180 180 ALA ALA B . n B 1 161 GLY 161 181 181 GLY GLY B . n B 1 162 GLY 162 182 182 GLY GLY B . n B 1 163 TYR 163 183 183 TYR TYR B . n B 1 164 SER 164 184 184 SER SER B . n B 1 165 LEU 165 185 185 LEU LEU B . n B 1 166 SER 166 186 186 SER SER B . n B 1 167 VAL 167 187 187 VAL VAL B . n B 1 168 ALA 168 188 188 ALA ALA B . n B 1 169 LYS 169 189 189 LYS LYS B . n B 1 170 THR 170 190 190 THR THR B . n B 1 171 TYR 171 191 191 TYR TYR B . n B 1 172 ALA 172 192 192 ALA ALA B . n B 1 173 ASP 173 193 193 ASP ASP B . n B 1 174 LEU 174 194 194 LEU LEU B . n B 1 175 LEU 175 195 195 LEU LEU B . n B 1 176 THR 176 196 196 THR THR B . n B 1 177 GLU 177 197 197 GLU GLU B . n B 1 178 ARG 178 198 198 ARG ARG B . n B 1 179 ILE 179 199 199 ILE ILE B . n B 1 180 LYS 180 200 200 LYS LYS B . n B 1 181 THR 181 201 201 THR THR B . n B 1 182 GLY 182 202 202 GLY GLY B . n B 1 183 THR 183 203 203 THR THR B . n B 1 184 TYR 184 204 204 TYR TYR B . n B 1 185 SER 185 205 205 SER SER B . n B 1 186 SER 186 206 206 SER SER B . n B 1 187 LYS 187 207 207 LYS LYS B . n B 1 188 LYS 188 208 208 LYS LYS B . n B 1 189 ASP 189 209 209 ASP ASP B . n B 1 190 SER 190 210 210 SER SER B . n B 1 191 TRP 191 211 211 TRP TRP B . n B 1 192 THR 192 212 212 THR THR B . n B 1 193 ASP 193 213 213 ASP ASP B . n B 1 194 GLY 194 214 214 GLY GLY B . n B 1 195 ILE 195 215 215 ILE ILE B . n B 1 196 ASP 196 216 216 ASP ASP B . n B 1 197 ILE 197 217 217 ILE ILE B . n B 1 198 LYS 198 218 218 LYS LYS B . n B 1 199 ASP 199 219 219 ASP ASP B . n B 1 200 PRO 200 220 220 PRO PRO B . n B 1 201 VAL 201 221 221 VAL VAL B . n B 1 202 SER 202 222 222 SER SER B . n B 1 203 THR 203 223 223 THR THR B . n B 1 204 SER 204 224 224 SER SER B . n B 1 205 MET 205 225 225 MET MET B . n B 1 206 ILE 206 226 226 ILE ILE B . n B 1 207 TRP 207 227 227 TRP TRP B . n B 1 208 ALA 208 228 228 ALA ALA B . n B 1 209 ALA 209 229 229 ALA ALA B . n B 1 210 ASP 210 230 230 ASP ASP B . n B 1 211 ALA 211 231 231 ALA ALA B . n B 1 212 ASN 212 232 232 ASN ASN B . n B 1 213 THR 213 233 233 THR THR B . n B 1 214 TYR 214 234 234 TYR TYR B . n B 1 215 VAL 215 235 235 VAL VAL B . n B 1 216 CYS 216 236 236 CYS CYS B . n B 1 217 SER 217 237 237 SER SER B . n B 1 218 THR 218 238 238 THR THR B . n B 1 219 VAL 219 239 239 VAL VAL B . n B 1 220 LEU 220 240 240 LEU LEU B . n B 1 221 ASP 221 241 241 ASP ASP B . n B 1 222 ASP 222 242 242 ASP ASP B . n B 1 223 GLY 223 243 243 GLY GLY B . n B 1 224 LEU 224 244 244 LEU LEU B . n B 1 225 ALA 225 245 245 ALA ALA B . n B 1 226 TYR 226 246 246 TYR TYR B . n B 1 227 ILE 227 247 247 ILE ILE B . n B 1 228 ASN 228 248 248 ASN ASN B . n B 1 229 SER 229 249 249 SER SER B . n B 1 230 THR 230 250 250 THR THR B . n B 1 231 ASP 231 251 251 ASP ASP B . n B 1 232 LEU 232 252 252 LEU LEU B . n B 1 233 SER 233 253 253 SER SER B . n B 1 234 GLY 234 254 254 GLY GLY B . n B 1 235 GLU 235 255 255 GLU GLU B . n B 1 236 TYR 236 256 256 TYR TYR B . n B 1 237 TYR 237 257 257 TYR TYR B . n B 1 238 ASP 238 258 258 ASP ASP B . n B 1 239 LYS 239 259 259 LYS LYS B . n B 1 240 SER 240 260 260 SER SER B . n B 1 241 GLN 241 261 261 GLN GLN B . n B 1 242 PRO 242 262 262 PRO PRO B . n B 1 243 VAL 243 263 263 VAL VAL B . n B 1 244 PHE 244 264 264 PHE PHE B . n B 1 245 GLU 245 265 265 GLU GLU B . n B 1 246 GLU 246 266 266 GLU GLU B . n B 1 247 LEU 247 267 267 LEU LEU B . n B 1 248 ILE 248 268 268 ILE ILE B . n B 1 249 ALA 249 269 269 ALA ALA B . n B 1 250 LYS 250 270 270 LYS LYS B . n B 1 251 ALA 251 271 271 ALA ALA B . n B 1 252 GLY 252 272 272 GLY GLY B . n B 1 253 TYR 253 273 273 TYR TYR B . n B 1 254 ARG 254 274 274 ARG ARG B . n B 1 255 LEU 255 275 275 LEU LEU B . n B 1 256 ALA 256 276 276 ALA ALA B . n B 1 257 ALA 257 277 277 ALA ALA B . n B 1 258 TRP 258 278 278 TRP TRP B . n B 1 259 LEU 259 279 279 LEU LEU B . n B 1 260 ASP 260 280 280 ASP ASP B . n B 1 261 LEU 261 281 281 LEU LEU B . n B 1 262 ILE 262 282 282 ILE ILE B . n B 1 263 ALA 263 283 283 ALA ALA B . n B 1 264 SER 264 284 284 SER SER B . n B 1 265 GLN 265 285 285 GLN GLN B . n B 1 266 PRO 266 286 ? ? ? B . n B 1 267 SER 267 287 ? ? ? B . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code C 2 ZN 1 401 401 ZN ZN A . D 2 ZN 1 402 402 ZN ZN A . E 2 ZN 1 403 403 ZN ZN A . F 3 NAG 1 501 501 NAG NAG A . G 3 NAG 1 502 502 NAG NAG A . H 4 PO4 1 601 601 PO4 PO4 A . I 5 DCZ 1 701 701 DCZ DCZ A . J 5 DCZ 1 702 702 DCZ DCZ A . K 2 ZN 1 401 401 ZN ZN B . L 2 ZN 1 402 402 ZN ZN B . M 2 ZN 1 403 403 ZN ZN B . N 3 NAG 1 501 501 NAG NAG B . O 3 NAG 1 502 502 NAG NAG B . P 4 PO4 1 601 601 PO4 PO4 B . Q 6 GNG 1 701 701 GNG GNG B . R 7 HOH 1 1001 1440 HOH HOH A . R 7 HOH 2 1002 1439 HOH HOH A . R 7 HOH 3 1003 1201 HOH HOH A . R 7 HOH 4 1004 1054 HOH HOH A . R 7 HOH 5 1005 1038 HOH HOH A . R 7 HOH 6 1006 1383 HOH HOH A . R 7 HOH 7 1007 1444 HOH HOH A . R 7 HOH 8 1008 961 HOH HOH A . R 7 HOH 9 1009 922 HOH HOH A . R 7 HOH 10 1010 1362 HOH HOH A . R 7 HOH 11 1011 1044 HOH HOH A . R 7 HOH 12 1012 1130 HOH HOH A . R 7 HOH 13 1013 1355 HOH HOH A . R 7 HOH 14 1014 1232 HOH HOH A . R 7 HOH 15 1015 1378 HOH HOH A . R 7 HOH 16 1016 1086 HOH HOH A . R 7 HOH 17 1017 1112 HOH HOH A . R 7 HOH 18 1018 865 HOH HOH A . R 7 HOH 19 1019 1078 HOH HOH A . R 7 HOH 20 1020 831 HOH HOH A . R 7 HOH 21 1021 1115 HOH HOH A . R 7 HOH 22 1022 1123 HOH HOH A . R 7 HOH 23 1023 857 HOH HOH A . R 7 HOH 24 1024 1164 HOH HOH A . R 7 HOH 25 1025 1301 HOH HOH A . R 7 HOH 26 1026 1280 HOH HOH A . R 7 HOH 27 1027 1045 HOH HOH A . R 7 HOH 28 1028 1142 HOH HOH A . R 7 HOH 29 1029 936 HOH HOH A . R 7 HOH 30 1030 1347 HOH HOH A . R 7 HOH 31 1031 892 HOH HOH A . R 7 HOH 32 1032 1145 HOH HOH A . R 7 HOH 33 1033 939 HOH HOH A . R 7 HOH 34 1034 956 HOH HOH A . R 7 HOH 35 1035 900 HOH HOH A . R 7 HOH 36 1036 960 HOH HOH A . R 7 HOH 37 1037 969 HOH HOH A . R 7 HOH 38 1038 940 HOH HOH A . R 7 HOH 39 1039 873 HOH HOH A . R 7 HOH 40 1040 1127 HOH HOH A . R 7 HOH 41 1041 1118 HOH HOH A . R 7 HOH 42 1042 858 HOH HOH A . R 7 HOH 43 1043 972 HOH HOH A . R 7 HOH 44 1044 1390 HOH HOH A . R 7 HOH 45 1045 816 HOH HOH A . R 7 HOH 46 1046 1004 HOH HOH A . R 7 HOH 47 1047 1171 HOH HOH A . R 7 HOH 48 1048 1417 HOH HOH A . R 7 HOH 49 1049 838 HOH HOH A . R 7 HOH 50 1050 1235 HOH HOH A . R 7 HOH 51 1051 1036 HOH HOH A . R 7 HOH 52 1052 1030 HOH HOH A . R 7 HOH 53 1053 878 HOH HOH A . R 7 HOH 54 1054 1327 HOH HOH A . R 7 HOH 55 1055 947 HOH HOH A . R 7 HOH 56 1056 852 HOH HOH A . R 7 HOH 57 1057 1168 HOH HOH A . R 7 HOH 58 1058 850 HOH HOH A . R 7 HOH 59 1059 964 HOH HOH A . R 7 HOH 60 1060 942 HOH HOH A . R 7 HOH 61 1061 979 HOH HOH A . R 7 HOH 62 1062 925 HOH HOH A . R 7 HOH 63 1063 854 HOH HOH A . R 7 HOH 64 1064 810 HOH HOH A . R 7 HOH 65 1065 1297 HOH HOH A . R 7 HOH 66 1066 1346 HOH HOH A . R 7 HOH 67 1067 1328 HOH HOH A . R 7 HOH 68 1068 1124 HOH HOH A . R 7 HOH 69 1069 1136 HOH HOH A . R 7 HOH 70 1070 820 HOH HOH A . R 7 HOH 71 1071 827 HOH HOH A . R 7 HOH 72 1072 957 HOH HOH A . R 7 HOH 73 1073 973 HOH HOH A . R 7 HOH 74 1074 1226 HOH HOH A . R 7 HOH 75 1075 902 HOH HOH A . R 7 HOH 76 1076 1452 HOH HOH A . R 7 HOH 77 1077 889 HOH HOH A . R 7 HOH 78 1078 1083 HOH HOH A . R 7 HOH 79 1079 1059 HOH HOH A . R 7 HOH 80 1080 1208 HOH HOH A . R 7 HOH 81 1081 1000 HOH HOH A . R 7 HOH 82 1082 1061 HOH HOH A . R 7 HOH 83 1083 1090 HOH HOH A . R 7 HOH 84 1084 1076 HOH HOH A . R 7 HOH 85 1085 1011 HOH HOH A . R 7 HOH 86 1086 1042 HOH HOH A . R 7 HOH 87 1087 1096 HOH HOH A . R 7 HOH 88 1088 1152 HOH HOH A . R 7 HOH 89 1089 818 HOH HOH A . R 7 HOH 90 1090 983 HOH HOH A . R 7 HOH 91 1091 958 HOH HOH A . R 7 HOH 92 1092 1204 HOH HOH A . R 7 HOH 93 1093 948 HOH HOH A . R 7 HOH 94 1094 929 HOH HOH A . R 7 HOH 95 1095 917 HOH HOH A . R 7 HOH 96 1096 1021 HOH HOH A . R 7 HOH 97 1097 1069 HOH HOH A . R 7 HOH 98 1098 848 HOH HOH A . R 7 HOH 99 1099 1250 HOH HOH A . R 7 HOH 100 1100 863 HOH HOH A . R 7 HOH 101 1101 901 HOH HOH A . R 7 HOH 102 1102 849 HOH HOH A . R 7 HOH 103 1103 1160 HOH HOH A . R 7 HOH 104 1104 844 HOH HOH A . R 7 HOH 105 1105 1234 HOH HOH A . R 7 HOH 106 1106 1084 HOH HOH A . R 7 HOH 107 1107 1103 HOH HOH A . R 7 HOH 108 1108 1169 HOH HOH A . R 7 HOH 109 1109 1351 HOH HOH A . R 7 HOH 110 1110 879 HOH HOH A . R 7 HOH 111 1111 888 HOH HOH A . R 7 HOH 112 1112 1149 HOH HOH A . R 7 HOH 113 1113 1217 HOH HOH A . R 7 HOH 114 1114 905 HOH HOH A . R 7 HOH 115 1115 1087 HOH HOH A . R 7 HOH 116 1116 1213 HOH HOH A . R 7 HOH 117 1117 856 HOH HOH A . R 7 HOH 118 1118 988 HOH HOH A . R 7 HOH 119 1119 822 HOH HOH A . R 7 HOH 120 1120 1040 HOH HOH A . R 7 HOH 121 1121 1352 HOH HOH A . R 7 HOH 122 1122 875 HOH HOH A . R 7 HOH 123 1123 1252 HOH HOH A . R 7 HOH 124 1124 1095 HOH HOH A . R 7 HOH 125 1125 896 HOH HOH A . R 7 HOH 126 805 805 HOH HOH A . R 7 HOH 127 1127 1167 HOH HOH A . R 7 HOH 128 1128 1409 HOH HOH A . R 7 HOH 129 1129 1179 HOH HOH A . R 7 HOH 130 1130 1432 HOH HOH A . R 7 HOH 131 1131 966 HOH HOH A . R 7 HOH 132 1132 1077 HOH HOH A . R 7 HOH 133 1133 1071 HOH HOH A . R 7 HOH 134 1134 1192 HOH HOH A . R 7 HOH 135 1135 1024 HOH HOH A . R 7 HOH 136 1136 1408 HOH HOH A . R 7 HOH 137 1137 817 HOH HOH A . R 7 HOH 138 1138 1395 HOH HOH A . R 7 HOH 139 1139 986 HOH HOH A . R 7 HOH 140 1140 915 HOH HOH A . R 7 HOH 141 1141 1314 HOH HOH A . R 7 HOH 142 1142 1014 HOH HOH A . R 7 HOH 143 1143 1302 HOH HOH A . R 7 HOH 144 1144 907 HOH HOH A . R 7 HOH 145 1145 963 HOH HOH A . R 7 HOH 146 1146 1203 HOH HOH A . R 7 HOH 147 1147 1008 HOH HOH A . R 7 HOH 148 1148 1023 HOH HOH A . R 7 HOH 149 1149 1182 HOH HOH A . R 7 HOH 150 1150 890 HOH HOH A . R 7 HOH 151 1151 1153 HOH HOH A . R 7 HOH 152 1152 1191 HOH HOH A . R 7 HOH 153 1153 910 HOH HOH A . R 7 HOH 154 1154 821 HOH HOH A . R 7 HOH 155 1155 1117 HOH HOH A . R 7 HOH 156 1156 1017 HOH HOH A . R 7 HOH 157 1157 837 HOH HOH A . R 7 HOH 158 1158 1091 HOH HOH A . R 7 HOH 159 1159 835 HOH HOH A . R 7 HOH 160 1160 808 HOH HOH A . R 7 HOH 161 1161 867 HOH HOH A . R 7 HOH 162 1162 1407 HOH HOH A . R 7 HOH 163 1163 1426 HOH HOH A . R 7 HOH 164 1164 840 HOH HOH A . R 7 HOH 165 1165 928 HOH HOH A . R 7 HOH 166 1166 1421 HOH HOH A . R 7 HOH 167 1167 1312 HOH HOH A . R 7 HOH 168 1168 1361 HOH HOH A . R 7 HOH 169 1169 926 HOH HOH A . R 7 HOH 170 1170 974 HOH HOH A . R 7 HOH 171 1171 908 HOH HOH A . R 7 HOH 172 1172 1062 HOH HOH A . R 7 HOH 173 1173 1288 HOH HOH A . R 7 HOH 174 1174 932 HOH HOH A . R 7 HOH 175 1175 1329 HOH HOH A . R 7 HOH 176 1176 1345 HOH HOH A . R 7 HOH 177 1177 1228 HOH HOH A . R 7 HOH 178 1178 1356 HOH HOH A . R 7 HOH 179 1179 1365 HOH HOH A . R 7 HOH 180 1180 1305 HOH HOH A . R 7 HOH 181 1181 916 HOH HOH A . R 7 HOH 182 1182 1037 HOH HOH A . R 7 HOH 183 1183 1031 HOH HOH A . R 7 HOH 184 1184 872 HOH HOH A . R 7 HOH 185 1185 1100 HOH HOH A . R 7 HOH 186 1186 1132 HOH HOH A . R 7 HOH 187 1187 1098 HOH HOH A . R 7 HOH 188 1188 1067 HOH HOH A . R 7 HOH 189 1189 1366 HOH HOH A . R 7 HOH 190 1190 1379 HOH HOH A . R 7 HOH 191 1191 1224 HOH HOH A . R 7 HOH 192 1192 911 HOH HOH A . R 7 HOH 193 1193 1056 HOH HOH A . R 7 HOH 194 1194 998 HOH HOH A . R 7 HOH 195 1195 1283 HOH HOH A . R 7 HOH 196 1196 1298 HOH HOH A . R 7 HOH 197 1197 1012 HOH HOH A . R 7 HOH 198 1198 1285 HOH HOH A . R 7 HOH 199 1199 1029 HOH HOH A . R 7 HOH 200 1200 869 HOH HOH A . R 7 HOH 201 1201 1081 HOH HOH A . R 7 HOH 202 1202 1242 HOH HOH A . R 7 HOH 203 1203 860 HOH HOH A . R 7 HOH 204 1204 1380 HOH HOH A . R 7 HOH 205 1205 946 HOH HOH A . R 7 HOH 206 1206 1022 HOH HOH A . R 7 HOH 207 1207 930 HOH HOH A . R 7 HOH 208 1208 1107 HOH HOH A . R 7 HOH 209 1209 1082 HOH HOH A . R 7 HOH 210 1210 1072 HOH HOH A . R 7 HOH 211 1211 1162 HOH HOH A . R 7 HOH 212 1212 1388 HOH HOH A . R 7 HOH 213 1213 1016 HOH HOH A . R 7 HOH 214 1214 995 HOH HOH A . R 7 HOH 215 1215 1138 HOH HOH A . R 7 HOH 216 1216 1015 HOH HOH A . R 7 HOH 217 1217 997 HOH HOH A . R 7 HOH 218 1218 1410 HOH HOH A . R 7 HOH 219 1219 1357 HOH HOH A . R 7 HOH 220 1220 1287 HOH HOH A . R 7 HOH 221 1221 1354 HOH HOH A . R 7 HOH 222 1222 1039 HOH HOH A . R 7 HOH 223 1223 1384 HOH HOH A . R 7 HOH 224 1224 1009 HOH HOH A . R 7 HOH 225 1225 1229 HOH HOH A . R 7 HOH 226 1226 834 HOH HOH A . R 7 HOH 227 1227 1156 HOH HOH A . R 7 HOH 228 1228 1034 HOH HOH A . R 7 HOH 229 1229 971 HOH HOH A . R 7 HOH 230 1230 938 HOH HOH A . R 7 HOH 231 1231 1187 HOH HOH A . R 7 HOH 232 1232 1070 HOH HOH A . R 7 HOH 233 1233 1065 HOH HOH A . R 7 HOH 234 1234 809 HOH HOH A . R 7 HOH 235 1235 1290 HOH HOH A . R 7 HOH 236 1236 1238 HOH HOH A . R 7 HOH 237 1237 1058 HOH HOH A . R 7 HOH 238 1238 1363 HOH HOH A . R 7 HOH 239 1239 1180 HOH HOH A . R 7 HOH 240 1240 1333 HOH HOH A . R 7 HOH 241 1241 814 HOH HOH A . R 7 HOH 242 1242 1101 HOH HOH A . R 7 HOH 243 1243 833 HOH HOH A . R 7 HOH 244 1244 1396 HOH HOH A . R 7 HOH 245 1245 1140 HOH HOH A . R 7 HOH 246 1246 1406 HOH HOH A . R 7 HOH 247 1247 1185 HOH HOH A . R 7 HOH 248 1248 1364 HOH HOH A . R 7 HOH 249 1249 1300 HOH HOH A . R 7 HOH 250 1250 1382 HOH HOH A . R 7 HOH 251 1251 1225 HOH HOH A . R 7 HOH 252 1252 1441 HOH HOH A . R 7 HOH 253 1253 1245 HOH HOH A . R 7 HOH 254 1254 1218 HOH HOH A . R 7 HOH 255 1255 1035 HOH HOH A . R 7 HOH 256 1256 1060 HOH HOH A . R 7 HOH 257 1257 1401 HOH HOH A . R 7 HOH 258 1258 1281 HOH HOH A . R 7 HOH 259 1259 1148 HOH HOH A . R 7 HOH 260 1260 1309 HOH HOH A . R 7 HOH 261 1261 981 HOH HOH A . R 7 HOH 262 1262 1243 HOH HOH A . R 7 HOH 263 1263 1256 HOH HOH A . R 7 HOH 264 1264 1147 HOH HOH A . R 7 HOH 265 1265 1134 HOH HOH A . R 7 HOH 266 1266 1064 HOH HOH A . R 7 HOH 267 1267 1093 HOH HOH A . R 7 HOH 268 1268 976 HOH HOH A . R 7 HOH 269 1269 1442 HOH HOH A . R 7 HOH 270 1270 1350 HOH HOH A . R 7 HOH 271 1271 862 HOH HOH A . R 7 HOH 272 1272 1270 HOH HOH A . R 7 HOH 273 1273 1198 HOH HOH A . R 7 HOH 274 1274 807 HOH HOH A . R 7 HOH 275 1275 1007 HOH HOH A . R 7 HOH 276 1276 1353 HOH HOH A . R 7 HOH 277 1277 895 HOH HOH A . R 7 HOH 278 1278 1342 HOH HOH A . R 7 HOH 279 1279 1308 HOH HOH A . R 7 HOH 280 1280 1275 HOH HOH A . R 7 HOH 281 1281 1304 HOH HOH A . R 7 HOH 282 1282 1392 HOH HOH A . R 7 HOH 283 1283 866 HOH HOH A . R 7 HOH 284 1284 1420 HOH HOH A . R 7 HOH 285 1285 1170 HOH HOH A . R 7 HOH 286 1286 1263 HOH HOH A . R 7 HOH 287 1287 1278 HOH HOH A . R 7 HOH 288 1288 1183 HOH HOH A . R 7 HOH 289 1289 1370 HOH HOH A . R 7 HOH 290 1290 1359 HOH HOH A . R 7 HOH 291 1291 1215 HOH HOH A . R 7 HOH 292 1292 1231 HOH HOH A . R 7 HOH 293 1293 1416 HOH HOH A . R 7 HOH 294 1294 1158 HOH HOH A . R 7 HOH 295 1295 1268 HOH HOH A . R 7 HOH 296 1296 1431 HOH HOH A . R 7 HOH 297 1297 1254 HOH HOH A . R 7 HOH 298 1298 1394 HOH HOH A . R 7 HOH 299 1299 1047 HOH HOH A . R 7 HOH 300 1300 1400 HOH HOH A . R 7 HOH 301 1301 1255 HOH HOH A . R 7 HOH 302 1302 1063 HOH HOH A . R 7 HOH 303 1303 1099 HOH HOH A . R 7 HOH 304 1304 1257 HOH HOH A . R 7 HOH 305 1305 977 HOH HOH A . R 7 HOH 306 1306 1249 HOH HOH A . R 7 HOH 307 1307 1193 HOH HOH A . R 7 HOH 308 1308 1369 HOH HOH A . R 7 HOH 309 1309 1266 HOH HOH A . R 7 HOH 310 1310 1216 HOH HOH A . R 7 HOH 311 1311 1443 HOH HOH A . R 7 HOH 312 1312 1172 HOH HOH A . R 7 HOH 313 1313 1437 HOH HOH A . R 7 HOH 314 1314 1299 HOH HOH A . R 7 HOH 315 1315 970 HOH HOH A . R 7 HOH 316 1316 1415 HOH HOH A . R 7 HOH 317 1317 1151 HOH HOH A . R 7 HOH 318 1318 951 HOH HOH A . R 7 HOH 319 1319 1267 HOH HOH A . R 7 HOH 320 1320 975 HOH HOH A . R 7 HOH 321 1321 1403 HOH HOH A . R 7 HOH 322 1322 1175 HOH HOH A . R 7 HOH 323 1323 1053 HOH HOH A . R 7 HOH 324 1324 1385 HOH HOH A . R 7 HOH 325 1325 1144 HOH HOH A . R 7 HOH 326 1326 1367 HOH HOH A . R 7 HOH 327 1327 1397 HOH HOH A . R 7 HOH 328 1328 1055 HOH HOH A . R 7 HOH 329 1329 1340 HOH HOH A . R 7 HOH 330 1330 1414 HOH HOH A . R 7 HOH 331 1331 1221 HOH HOH A . R 7 HOH 332 1332 1247 HOH HOH A . R 7 HOH 333 1333 1211 HOH HOH A . R 7 HOH 334 1334 1277 HOH HOH A . R 7 HOH 335 1335 937 HOH HOH A . R 7 HOH 336 1336 1125 HOH HOH A . R 7 HOH 337 1337 1341 HOH HOH A . R 7 HOH 338 1338 1135 HOH HOH A . R 7 HOH 339 1339 1177 HOH HOH A . R 7 HOH 340 1340 921 HOH HOH A . R 7 HOH 341 1341 1246 HOH HOH A . S 7 HOH 1 1001 1438 HOH HOH B . S 7 HOH 2 1002 1338 HOH HOH B . S 7 HOH 3 1003 1423 HOH HOH B . S 7 HOH 4 1004 1141 HOH HOH B . S 7 HOH 5 1005 1447 HOH HOH B . S 7 HOH 6 1006 1239 HOH HOH B . S 7 HOH 7 1007 1089 HOH HOH B . S 7 HOH 8 1008 1194 HOH HOH B . S 7 HOH 9 1009 935 HOH HOH B . S 7 HOH 10 1010 824 HOH HOH B . S 7 HOH 11 1011 967 HOH HOH B . S 7 HOH 12 1012 1068 HOH HOH B . S 7 HOH 13 1013 909 HOH HOH B . S 7 HOH 14 1014 1137 HOH HOH B . S 7 HOH 15 1015 876 HOH HOH B . S 7 HOH 16 1016 894 HOH HOH B . S 7 HOH 17 1017 1079 HOH HOH B . S 7 HOH 18 1018 1075 HOH HOH B . S 7 HOH 19 1019 855 HOH HOH B . S 7 HOH 20 1020 1317 HOH HOH B . S 7 HOH 21 1021 851 HOH HOH B . S 7 HOH 22 1022 1429 HOH HOH B . S 7 HOH 23 1023 1163 HOH HOH B . S 7 HOH 24 1024 846 HOH HOH B . S 7 HOH 25 1025 993 HOH HOH B . S 7 HOH 26 1026 1003 HOH HOH B . S 7 HOH 27 1027 1322 HOH HOH B . S 7 HOH 28 1028 887 HOH HOH B . S 7 HOH 29 1029 1411 HOH HOH B . S 7 HOH 30 1030 1200 HOH HOH B . S 7 HOH 31 1031 839 HOH HOH B . S 7 HOH 32 1032 1109 HOH HOH B . S 7 HOH 33 1033 1315 HOH HOH B . S 7 HOH 34 1034 803 HOH HOH B . S 7 HOH 35 1035 1264 HOH HOH B . S 7 HOH 36 1036 985 HOH HOH B . S 7 HOH 37 1037 1121 HOH HOH B . S 7 HOH 38 1038 1202 HOH HOH B . S 7 HOH 39 1039 1375 HOH HOH B . S 7 HOH 40 1040 1105 HOH HOH B . S 7 HOH 41 1041 885 HOH HOH B . S 7 HOH 42 1042 953 HOH HOH B . S 7 HOH 43 1043 978 HOH HOH B . S 7 HOH 44 1044 1113 HOH HOH B . S 7 HOH 45 1045 1119 HOH HOH B . S 7 HOH 46 1046 836 HOH HOH B . S 7 HOH 47 1047 1173 HOH HOH B . S 7 HOH 48 1048 984 HOH HOH B . S 7 HOH 49 1049 1048 HOH HOH B . S 7 HOH 50 1050 913 HOH HOH B . S 7 HOH 51 1051 934 HOH HOH B . S 7 HOH 52 1052 1108 HOH HOH B . S 7 HOH 53 1053 903 HOH HOH B . S 7 HOH 54 1054 968 HOH HOH B . S 7 HOH 55 1055 1318 HOH HOH B . S 7 HOH 56 1056 891 HOH HOH B . S 7 HOH 57 1057 1020 HOH HOH B . S 7 HOH 58 1058 1126 HOH HOH B . S 7 HOH 59 1059 829 HOH HOH B . S 7 HOH 60 1060 931 HOH HOH B . S 7 HOH 61 1061 1052 HOH HOH B . S 7 HOH 62 1062 883 HOH HOH B . S 7 HOH 63 1063 1323 HOH HOH B . S 7 HOH 64 1064 1295 HOH HOH B . S 7 HOH 65 1065 1050 HOH HOH B . S 7 HOH 66 1066 880 HOH HOH B . S 7 HOH 67 1067 1195 HOH HOH B . S 7 HOH 68 1068 819 HOH HOH B . S 7 HOH 69 1069 1289 HOH HOH B . S 7 HOH 70 1070 1335 HOH HOH B . S 7 HOH 71 1071 882 HOH HOH B . S 7 HOH 72 1072 1286 HOH HOH B . S 7 HOH 73 1073 1196 HOH HOH B . S 7 HOH 74 805 805 HOH HOH B . S 7 HOH 75 1075 1102 HOH HOH B . S 7 HOH 76 1076 1085 HOH HOH B . S 7 HOH 77 1077 1320 HOH HOH B . S 7 HOH 78 1078 1311 HOH HOH B . S 7 HOH 79 1079 899 HOH HOH B . S 7 HOH 80 1080 1133 HOH HOH B . S 7 HOH 81 1081 1005 HOH HOH B . S 7 HOH 82 1082 859 HOH HOH B . S 7 HOH 83 1083 904 HOH HOH B . S 7 HOH 84 1084 919 HOH HOH B . S 7 HOH 85 1085 1032 HOH HOH B . S 7 HOH 86 1086 1284 HOH HOH B . S 7 HOH 87 1087 843 HOH HOH B . S 7 HOH 88 1088 861 HOH HOH B . S 7 HOH 89 1089 1223 HOH HOH B . S 7 HOH 90 1090 870 HOH HOH B . S 7 HOH 91 1091 987 HOH HOH B . S 7 HOH 92 1092 949 HOH HOH B . S 7 HOH 93 1093 991 HOH HOH B . S 7 HOH 94 1094 1026 HOH HOH B . S 7 HOH 95 1095 1321 HOH HOH B . S 7 HOH 96 1096 1097 HOH HOH B . S 7 HOH 97 1097 1337 HOH HOH B . S 7 HOH 98 1098 992 HOH HOH B . S 7 HOH 99 1099 1230 HOH HOH B . S 7 HOH 100 1100 1244 HOH HOH B . S 7 HOH 101 1101 871 HOH HOH B . S 7 HOH 102 1102 884 HOH HOH B . S 7 HOH 103 1103 982 HOH HOH B . S 7 HOH 104 1104 830 HOH HOH B . S 7 HOH 105 1105 990 HOH HOH B . S 7 HOH 106 1106 1094 HOH HOH B . S 7 HOH 107 1107 1253 HOH HOH B . S 7 HOH 108 1108 1233 HOH HOH B . S 7 HOH 109 1109 1205 HOH HOH B . S 7 HOH 110 1110 1418 HOH HOH B . S 7 HOH 111 1111 1434 HOH HOH B . S 7 HOH 112 1112 965 HOH HOH B . S 7 HOH 113 1113 1181 HOH HOH B . S 7 HOH 114 1114 950 HOH HOH B . S 7 HOH 115 1115 1110 HOH HOH B . S 7 HOH 116 1116 864 HOH HOH B . S 7 HOH 117 1117 955 HOH HOH B . S 7 HOH 118 1118 1001 HOH HOH B . S 7 HOH 119 1119 842 HOH HOH B . S 7 HOH 120 1120 1154 HOH HOH B . S 7 HOH 121 1121 847 HOH HOH B . S 7 HOH 122 1122 1454 HOH HOH B . S 7 HOH 123 1123 1332 HOH HOH B . S 7 HOH 124 1124 924 HOH HOH B . S 7 HOH 125 1125 868 HOH HOH B . S 7 HOH 126 1126 813 HOH HOH B . S 7 HOH 127 1127 1339 HOH HOH B . S 7 HOH 128 1128 945 HOH HOH B . S 7 HOH 129 1129 1306 HOH HOH B . S 7 HOH 130 1130 1111 HOH HOH B . S 7 HOH 131 1131 1210 HOH HOH B . S 7 HOH 132 1132 980 HOH HOH B . S 7 HOH 133 1133 1051 HOH HOH B . S 7 HOH 134 1134 1088 HOH HOH B . S 7 HOH 135 1135 825 HOH HOH B . S 7 HOH 136 1136 1131 HOH HOH B . S 7 HOH 137 1137 832 HOH HOH B . S 7 HOH 138 1138 823 HOH HOH B . S 7 HOH 139 1139 1319 HOH HOH B . S 7 HOH 140 1140 853 HOH HOH B . S 7 HOH 141 1141 806 HOH HOH B . S 7 HOH 142 1142 1381 HOH HOH B . S 7 HOH 143 1143 1393 HOH HOH B . S 7 HOH 144 1144 841 HOH HOH B . S 7 HOH 145 1145 1310 HOH HOH B . S 7 HOH 146 1146 1336 HOH HOH B . S 7 HOH 147 1147 1348 HOH HOH B . S 7 HOH 148 1148 1282 HOH HOH B . S 7 HOH 149 1149 912 HOH HOH B . S 7 HOH 150 1150 893 HOH HOH B . S 7 HOH 151 1151 1186 HOH HOH B . S 7 HOH 152 1152 989 HOH HOH B . S 7 HOH 153 1153 881 HOH HOH B . S 7 HOH 154 1154 898 HOH HOH B . S 7 HOH 155 1155 1313 HOH HOH B . S 7 HOH 156 1156 1324 HOH HOH B . S 7 HOH 157 1157 994 HOH HOH B . S 7 HOH 158 1158 1433 HOH HOH B . S 7 HOH 159 1159 927 HOH HOH B . S 7 HOH 160 1160 1292 HOH HOH B . S 7 HOH 161 1161 1316 HOH HOH B . S 7 HOH 162 1162 918 HOH HOH B . S 7 HOH 163 1163 1209 HOH HOH B . S 7 HOH 164 1164 1106 HOH HOH B . S 7 HOH 165 1165 1041 HOH HOH B . S 7 HOH 166 1166 954 HOH HOH B . S 7 HOH 167 1167 923 HOH HOH B . S 7 HOH 168 1168 1334 HOH HOH B . S 7 HOH 169 1169 886 HOH HOH B . S 7 HOH 170 1170 1006 HOH HOH B . S 7 HOH 171 1171 1155 HOH HOH B . S 7 HOH 172 1172 999 HOH HOH B . S 7 HOH 173 1173 1448 HOH HOH B . S 7 HOH 174 1174 1349 HOH HOH B . S 7 HOH 175 1175 1358 HOH HOH B . S 7 HOH 176 1176 944 HOH HOH B . S 7 HOH 177 1177 815 HOH HOH B . S 7 HOH 178 1178 943 HOH HOH B . S 7 HOH 179 1179 1412 HOH HOH B . S 7 HOH 180 1180 1343 HOH HOH B . S 7 HOH 181 1181 1073 HOH HOH B . S 7 HOH 182 1182 1227 HOH HOH B . S 7 HOH 183 1183 1376 HOH HOH B . S 7 HOH 184 1184 1018 HOH HOH B . S 7 HOH 185 1185 1092 HOH HOH B . S 7 HOH 186 1186 1197 HOH HOH B . S 7 HOH 187 1187 952 HOH HOH B . S 7 HOH 188 1188 1331 HOH HOH B . S 7 HOH 189 1189 1122 HOH HOH B . S 7 HOH 190 1190 812 HOH HOH B . S 7 HOH 191 1191 828 HOH HOH B . S 7 HOH 192 1192 1214 HOH HOH B . S 7 HOH 193 1193 1157 HOH HOH B . S 7 HOH 194 1194 1188 HOH HOH B . S 7 HOH 195 1195 1419 HOH HOH B . S 7 HOH 196 1196 1360 HOH HOH B . S 7 HOH 197 1197 959 HOH HOH B . S 7 HOH 198 1198 1146 HOH HOH B . S 7 HOH 199 1199 1028 HOH HOH B . S 7 HOH 200 1200 1199 HOH HOH B . S 7 HOH 201 1201 1261 HOH HOH B . S 7 HOH 202 1202 1303 HOH HOH B . S 7 HOH 203 1203 933 HOH HOH B . S 7 HOH 204 1204 877 HOH HOH B . S 7 HOH 205 1205 1405 HOH HOH B . S 7 HOH 206 1206 845 HOH HOH B . S 7 HOH 207 1207 1116 HOH HOH B . S 7 HOH 208 1208 1166 HOH HOH B . S 7 HOH 209 1209 1296 HOH HOH B . S 7 HOH 210 1210 962 HOH HOH B . S 7 HOH 211 1211 1240 HOH HOH B . S 7 HOH 212 1212 1372 HOH HOH B . S 7 HOH 213 1213 874 HOH HOH B . S 7 HOH 214 1214 1066 HOH HOH B . S 7 HOH 215 1215 1019 HOH HOH B . S 7 HOH 216 1216 1276 HOH HOH B . S 7 HOH 217 1217 1402 HOH HOH B . S 7 HOH 218 1218 1159 HOH HOH B . S 7 HOH 219 1219 996 HOH HOH B . S 7 HOH 220 1220 897 HOH HOH B . S 7 HOH 221 1221 1143 HOH HOH B . S 7 HOH 222 1222 1114 HOH HOH B . S 7 HOH 223 1223 811 HOH HOH B . S 7 HOH 224 1224 826 HOH HOH B . S 7 HOH 225 1225 1057 HOH HOH B . S 7 HOH 226 1226 1178 HOH HOH B . S 7 HOH 227 1227 1449 HOH HOH B . S 7 HOH 228 1228 1206 HOH HOH B . S 7 HOH 229 1229 1422 HOH HOH B . S 7 HOH 230 1230 1207 HOH HOH B . S 7 HOH 231 1231 1453 HOH HOH B . S 7 HOH 232 1232 1436 HOH HOH B . S 7 HOH 233 1233 1010 HOH HOH B . S 7 HOH 234 1234 1326 HOH HOH B . S 7 HOH 235 1235 1236 HOH HOH B . S 7 HOH 236 1236 1427 HOH HOH B . S 7 HOH 237 1237 1445 HOH HOH B . S 7 HOH 238 1238 1291 HOH HOH B . S 7 HOH 239 1239 1374 HOH HOH B . S 7 HOH 240 1240 1190 HOH HOH B . S 7 HOH 241 1241 1330 HOH HOH B . S 7 HOH 242 1242 1274 HOH HOH B . S 7 HOH 243 1243 1307 HOH HOH B . S 7 HOH 244 1244 1189 HOH HOH B . S 7 HOH 245 1245 1272 HOH HOH B . S 7 HOH 246 1246 1293 HOH HOH B . S 7 HOH 247 1247 1025 HOH HOH B . S 7 HOH 248 1248 1391 HOH HOH B . S 7 HOH 249 1249 1260 HOH HOH B . S 7 HOH 250 1250 906 HOH HOH B . S 7 HOH 251 1251 1120 HOH HOH B . S 7 HOH 252 1252 1294 HOH HOH B . S 7 HOH 253 1253 1013 HOH HOH B . S 7 HOH 254 1254 1424 HOH HOH B . S 7 HOH 255 1255 1219 HOH HOH B . S 7 HOH 256 1256 1450 HOH HOH B . S 7 HOH 257 1257 1271 HOH HOH B . S 7 HOH 258 1258 1262 HOH HOH B . S 7 HOH 259 1259 1174 HOH HOH B . S 7 HOH 260 1260 1389 HOH HOH B . S 7 HOH 261 1261 1259 HOH HOH B . S 7 HOH 262 1262 1139 HOH HOH B . S 7 HOH 263 1263 1404 HOH HOH B . S 7 HOH 264 1264 1428 HOH HOH B . S 7 HOH 265 1265 1176 HOH HOH B . S 7 HOH 266 1266 1258 HOH HOH B . S 7 HOH 267 1267 1165 HOH HOH B . S 7 HOH 268 1268 1251 HOH HOH B . S 7 HOH 269 1269 1425 HOH HOH B . S 7 HOH 270 1270 1128 HOH HOH B . S 7 HOH 271 1271 1265 HOH HOH B . S 7 HOH 272 1272 1373 HOH HOH B . S 7 HOH 273 1273 920 HOH HOH B . S 7 HOH 274 1274 1344 HOH HOH B . S 7 HOH 275 1275 1237 HOH HOH B . S 7 HOH 276 1276 1212 HOH HOH B . S 7 HOH 277 1277 1325 HOH HOH B . S 7 HOH 278 1278 914 HOH HOH B . S 7 HOH 279 1279 1371 HOH HOH B . S 7 HOH 280 1280 1046 HOH HOH B . S 7 HOH 281 1281 1387 HOH HOH B . S 7 HOH 282 1282 1129 HOH HOH B . S 7 HOH 283 1283 1451 HOH HOH B . S 7 HOH 284 1284 1377 HOH HOH B . S 7 HOH 285 1285 1049 HOH HOH B . S 7 HOH 286 1286 1399 HOH HOH B . S 7 HOH 287 1287 1446 HOH HOH B . S 7 HOH 288 1288 1104 HOH HOH B . S 7 HOH 289 1289 1273 HOH HOH B . S 7 HOH 290 1290 1184 HOH HOH B . S 7 HOH 291 1291 1027 HOH HOH B . S 7 HOH 292 1292 1222 HOH HOH B . S 7 HOH 293 1293 1241 HOH HOH B . S 7 HOH 294 1294 1398 HOH HOH B . S 7 HOH 295 1295 941 HOH HOH B . S 7 HOH 296 1296 1161 HOH HOH B . S 7 HOH 297 1297 1080 HOH HOH B . S 7 HOH 298 1298 1269 HOH HOH B . S 7 HOH 299 1299 1430 HOH HOH B . S 7 HOH 300 1300 1043 HOH HOH B . S 7 HOH 301 1301 1368 HOH HOH B . S 7 HOH 302 1302 1248 HOH HOH B . S 7 HOH 303 1303 1386 HOH HOH B . S 7 HOH 304 1304 1033 HOH HOH B . S 7 HOH 305 1305 1002 HOH HOH B . S 7 HOH 306 1306 1150 HOH HOH B . S 7 HOH 307 1307 1220 HOH HOH B . S 7 HOH 308 1308 1279 HOH HOH B . S 7 HOH 309 1309 1435 HOH HOH B . S 7 HOH 310 1310 1074 HOH HOH B . S 7 HOH 311 1311 1413 HOH HOH B . # loop_ _pdbx_struct_assembly.id _pdbx_struct_assembly.details _pdbx_struct_assembly.method_details _pdbx_struct_assembly.oligomeric_details _pdbx_struct_assembly.oligomeric_count 1 author_defined_assembly ? monomeric 1 2 author_defined_assembly ? monomeric 1 # loop_ _pdbx_struct_assembly_gen.assembly_id _pdbx_struct_assembly_gen.oper_expression _pdbx_struct_assembly_gen.asym_id_list 1 1 A,C,D,E,F,G,H,I,J,R 2 1 B,K,L,M,N,O,P,Q,S # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # _pdbx_struct_special_symmetry.id 1 _pdbx_struct_special_symmetry.PDB_model_num 1 _pdbx_struct_special_symmetry.auth_asym_id A _pdbx_struct_special_symmetry.auth_comp_id HOH _pdbx_struct_special_symmetry.auth_seq_id 1193 _pdbx_struct_special_symmetry.PDB_ins_code ? _pdbx_struct_special_symmetry.label_asym_id R _pdbx_struct_special_symmetry.label_comp_id HOH _pdbx_struct_special_symmetry.label_seq_id . # loop_ _pdbx_struct_conn_angle.id _pdbx_struct_conn_angle.ptnr1_label_atom_id _pdbx_struct_conn_angle.ptnr1_label_alt_id _pdbx_struct_conn_angle.ptnr1_label_asym_id _pdbx_struct_conn_angle.ptnr1_label_comp_id _pdbx_struct_conn_angle.ptnr1_label_seq_id _pdbx_struct_conn_angle.ptnr1_auth_atom_id _pdbx_struct_conn_angle.ptnr1_auth_asym_id _pdbx_struct_conn_angle.ptnr1_auth_comp_id _pdbx_struct_conn_angle.ptnr1_auth_seq_id _pdbx_struct_conn_angle.ptnr1_PDB_ins_code _pdbx_struct_conn_angle.ptnr1_symmetry _pdbx_struct_conn_angle.ptnr2_label_atom_id _pdbx_struct_conn_angle.ptnr2_label_alt_id _pdbx_struct_conn_angle.ptnr2_label_asym_id _pdbx_struct_conn_angle.ptnr2_label_comp_id _pdbx_struct_conn_angle.ptnr2_label_seq_id _pdbx_struct_conn_angle.ptnr2_auth_atom_id _pdbx_struct_conn_angle.ptnr2_auth_asym_id _pdbx_struct_conn_angle.ptnr2_auth_comp_id _pdbx_struct_conn_angle.ptnr2_auth_seq_id _pdbx_struct_conn_angle.ptnr2_PDB_ins_code _pdbx_struct_conn_angle.ptnr2_symmetry _pdbx_struct_conn_angle.ptnr3_label_atom_id _pdbx_struct_conn_angle.ptnr3_label_alt_id _pdbx_struct_conn_angle.ptnr3_label_asym_id _pdbx_struct_conn_angle.ptnr3_label_comp_id _pdbx_struct_conn_angle.ptnr3_label_seq_id _pdbx_struct_conn_angle.ptnr3_auth_atom_id _pdbx_struct_conn_angle.ptnr3_auth_asym_id _pdbx_struct_conn_angle.ptnr3_auth_comp_id _pdbx_struct_conn_angle.ptnr3_auth_seq_id _pdbx_struct_conn_angle.ptnr3_PDB_ins_code _pdbx_struct_conn_angle.ptnr3_symmetry _pdbx_struct_conn_angle.value _pdbx_struct_conn_angle.value_esd 1 N ? A TRP 1 ? A TRP 21 ? 1_555 ZN ? C ZN . ? A ZN 401 ? 1_555 O ? A TRP 1 ? A TRP 21 ? 1_555 77.4 ? 2 N ? A TRP 1 ? A TRP 21 ? 1_555 ZN ? C ZN . ? A ZN 401 ? 1_555 NE2 ? A HIS 6 ? A HIS 26 ? 1_555 109.9 ? 3 O ? A TRP 1 ? A TRP 21 ? 1_555 ZN ? C ZN . ? A ZN 401 ? 1_555 NE2 ? A HIS 6 ? A HIS 26 ? 1_555 88.9 ? 4 N ? A TRP 1 ? A TRP 21 ? 1_555 ZN ? C ZN . ? A ZN 401 ? 1_555 OD1 ? A ASP 119 ? A ASP 139 ? 1_555 89.8 ? 5 O ? A TRP 1 ? A TRP 21 ? 1_555 ZN ? C ZN . ? A ZN 401 ? 1_555 OD1 ? A ASP 119 ? A ASP 139 ? 1_555 166.8 ? 6 NE2 ? A HIS 6 ? A HIS 26 ? 1_555 ZN ? C ZN . ? A ZN 401 ? 1_555 OD1 ? A ASP 119 ? A ASP 139 ? 1_555 92.4 ? 7 N ? A TRP 1 ? A TRP 21 ? 1_555 ZN ? C ZN . ? A ZN 401 ? 1_555 O1 ? H PO4 . ? A PO4 601 ? 1_555 131.6 ? 8 O ? A TRP 1 ? A TRP 21 ? 1_555 ZN ? C ZN . ? A ZN 401 ? 1_555 O1 ? H PO4 . ? A PO4 601 ? 1_555 90.6 ? 9 NE2 ? A HIS 6 ? A HIS 26 ? 1_555 ZN ? C ZN . ? A ZN 401 ? 1_555 O1 ? H PO4 . ? A PO4 601 ? 1_555 116.7 ? 10 OD1 ? A ASP 119 ? A ASP 139 ? 1_555 ZN ? C ZN . ? A ZN 401 ? 1_555 O1 ? H PO4 . ? A PO4 601 ? 1_555 100.6 ? 11 OD1 ? A ASN 45 ? A ASN 65 ? 1_555 ZN ? D ZN . ? A ZN 402 ? 1_555 ND1 ? A HIS 60 ? A HIS 80 ? 1_555 83.3 ? 12 OD1 ? A ASN 45 ? A ASN 65 ? 1_555 ZN ? D ZN . ? A ZN 402 ? 1_555 NE2 ? A HIS 115 ? A HIS 135 ? 1_555 81.8 ? 13 ND1 ? A HIS 60 ? A HIS 80 ? 1_555 ZN ? D ZN . ? A ZN 402 ? 1_555 NE2 ? A HIS 115 ? A HIS 135 ? 1_555 99.6 ? 14 OD1 ? A ASN 45 ? A ASN 65 ? 1_555 ZN ? D ZN . ? A ZN 402 ? 1_555 OD2 ? A ASP 119 ? A ASP 139 ? 1_555 171.3 ? 15 ND1 ? A HIS 60 ? A HIS 80 ? 1_555 ZN ? D ZN . ? A ZN 402 ? 1_555 OD2 ? A ASP 119 ? A ASP 139 ? 1_555 97.7 ? 16 NE2 ? A HIS 115 ? A HIS 135 ? 1_555 ZN ? D ZN . ? A ZN 402 ? 1_555 OD2 ? A ASP 119 ? A ASP 139 ? 1_555 89.5 ? 17 OD1 ? A ASN 45 ? A ASN 65 ? 1_555 ZN ? D ZN . ? A ZN 402 ? 1_555 O1 ? H PO4 . ? A PO4 601 ? 1_555 85.2 ? 18 ND1 ? A HIS 60 ? A HIS 80 ? 1_555 ZN ? D ZN . ? A ZN 402 ? 1_555 O1 ? H PO4 . ? A PO4 601 ? 1_555 158.7 ? 19 NE2 ? A HIS 115 ? A HIS 135 ? 1_555 ZN ? D ZN . ? A ZN 402 ? 1_555 O1 ? H PO4 . ? A PO4 601 ? 1_555 96.5 ? 20 OD2 ? A ASP 119 ? A ASP 139 ? 1_555 ZN ? D ZN . ? A ZN 402 ? 1_555 O1 ? H PO4 . ? A PO4 601 ? 1_555 96.3 ? 21 OD1 ? A ASN 45 ? A ASN 65 ? 1_555 ZN ? D ZN . ? A ZN 402 ? 1_555 O2 ? H PO4 . ? A PO4 601 ? 1_555 86.2 ? 22 ND1 ? A HIS 60 ? A HIS 80 ? 1_555 ZN ? D ZN . ? A ZN 402 ? 1_555 O2 ? H PO4 . ? A PO4 601 ? 1_555 98.1 ? 23 NE2 ? A HIS 115 ? A HIS 135 ? 1_555 ZN ? D ZN . ? A ZN 402 ? 1_555 O2 ? H PO4 . ? A PO4 601 ? 1_555 157.3 ? 24 OD2 ? A ASP 119 ? A ASP 139 ? 1_555 ZN ? D ZN . ? A ZN 402 ? 1_555 O2 ? H PO4 . ? A PO4 601 ? 1_555 102.2 ? 25 O1 ? H PO4 . ? A PO4 601 ? 1_555 ZN ? D ZN . ? A ZN 402 ? 1_555 O2 ? H PO4 . ? A PO4 601 ? 1_555 63.2 ? 26 NE2 ? A HIS 125 ? A HIS 145 ? 1_555 ZN ? E ZN . ? A ZN 403 ? 1_555 NE2 ? A HIS 148 ? A HIS 168 ? 1_555 99.0 ? 27 NE2 ? A HIS 125 ? A HIS 145 ? 1_555 ZN ? E ZN . ? A ZN 403 ? 1_555 OD1 ? A ASP 152 ? A ASP 172 ? 1_555 96.4 ? 28 NE2 ? A HIS 148 ? A HIS 168 ? 1_555 ZN ? E ZN . ? A ZN 403 ? 1_555 OD1 ? A ASP 152 ? A ASP 172 ? 1_555 95.6 ? 29 NE2 ? A HIS 125 ? A HIS 145 ? 1_555 ZN ? E ZN . ? A ZN 403 ? 1_555 OD2 ? A ASP 152 ? A ASP 172 ? 1_555 148.8 ? 30 NE2 ? A HIS 148 ? A HIS 168 ? 1_555 ZN ? E ZN . ? A ZN 403 ? 1_555 OD2 ? A ASP 152 ? A ASP 172 ? 1_555 95.1 ? 31 OD1 ? A ASP 152 ? A ASP 172 ? 1_555 ZN ? E ZN . ? A ZN 403 ? 1_555 OD2 ? A ASP 152 ? A ASP 172 ? 1_555 54.4 ? 32 NE2 ? A HIS 125 ? A HIS 145 ? 1_555 ZN ? E ZN . ? A ZN 403 ? 1_555 O3 ? H PO4 . ? A PO4 601 ? 1_555 95.0 ? 33 NE2 ? A HIS 148 ? A HIS 168 ? 1_555 ZN ? E ZN . ? A ZN 403 ? 1_555 O3 ? H PO4 . ? A PO4 601 ? 1_555 136.9 ? 34 OD1 ? A ASP 152 ? A ASP 172 ? 1_555 ZN ? E ZN . ? A ZN 403 ? 1_555 O3 ? H PO4 . ? A PO4 601 ? 1_555 123.1 ? 35 OD2 ? A ASP 152 ? A ASP 172 ? 1_555 ZN ? E ZN . ? A ZN 403 ? 1_555 O3 ? H PO4 . ? A PO4 601 ? 1_555 93.4 ? 36 N ? B TRP 1 ? B TRP 21 ? 1_555 ZN ? K ZN . ? B ZN 401 ? 1_555 O ? B TRP 1 ? B TRP 21 ? 1_555 78.1 ? 37 N ? B TRP 1 ? B TRP 21 ? 1_555 ZN ? K ZN . ? B ZN 401 ? 1_555 NE2 ? B HIS 6 ? B HIS 26 ? 1_555 113.7 ? 38 O ? B TRP 1 ? B TRP 21 ? 1_555 ZN ? K ZN . ? B ZN 401 ? 1_555 NE2 ? B HIS 6 ? B HIS 26 ? 1_555 89.7 ? 39 N ? B TRP 1 ? B TRP 21 ? 1_555 ZN ? K ZN . ? B ZN 401 ? 1_555 OD1 ? B ASP 119 ? B ASP 139 ? 1_555 91.0 ? 40 O ? B TRP 1 ? B TRP 21 ? 1_555 ZN ? K ZN . ? B ZN 401 ? 1_555 OD1 ? B ASP 119 ? B ASP 139 ? 1_555 168.9 ? 41 NE2 ? B HIS 6 ? B HIS 26 ? 1_555 ZN ? K ZN . ? B ZN 401 ? 1_555 OD1 ? B ASP 119 ? B ASP 139 ? 1_555 92.8 ? 42 N ? B TRP 1 ? B TRP 21 ? 1_555 ZN ? K ZN . ? B ZN 401 ? 1_555 O3 ? P PO4 . ? B PO4 601 ? 1_555 137.6 ? 43 O ? B TRP 1 ? B TRP 21 ? 1_555 ZN ? K ZN . ? B ZN 401 ? 1_555 O3 ? P PO4 . ? B PO4 601 ? 1_555 93.9 ? 44 NE2 ? B HIS 6 ? B HIS 26 ? 1_555 ZN ? K ZN . ? B ZN 401 ? 1_555 O3 ? P PO4 . ? B PO4 601 ? 1_555 107.7 ? 45 OD1 ? B ASP 119 ? B ASP 139 ? 1_555 ZN ? K ZN . ? B ZN 401 ? 1_555 O3 ? P PO4 . ? B PO4 601 ? 1_555 95.6 ? 46 ND1 ? B HIS 60 ? B HIS 80 ? 1_555 ZN ? L ZN . ? B ZN 402 ? 1_555 NE2 ? B HIS 115 ? B HIS 135 ? 1_555 97.1 ? 47 ND1 ? B HIS 60 ? B HIS 80 ? 1_555 ZN ? L ZN . ? B ZN 402 ? 1_555 OD2 ? B ASP 119 ? B ASP 139 ? 1_555 98.2 ? 48 NE2 ? B HIS 115 ? B HIS 135 ? 1_555 ZN ? L ZN . ? B ZN 402 ? 1_555 OD2 ? B ASP 119 ? B ASP 139 ? 1_555 92.3 ? 49 ND1 ? B HIS 60 ? B HIS 80 ? 1_555 ZN ? L ZN . ? B ZN 402 ? 1_555 O1 ? P PO4 . ? B PO4 601 ? 1_555 93.0 ? 50 NE2 ? B HIS 115 ? B HIS 135 ? 1_555 ZN ? L ZN . ? B ZN 402 ? 1_555 O1 ? P PO4 . ? B PO4 601 ? 1_555 160.3 ? 51 OD2 ? B ASP 119 ? B ASP 139 ? 1_555 ZN ? L ZN . ? B ZN 402 ? 1_555 O1 ? P PO4 . ? B PO4 601 ? 1_555 103.0 ? 52 ND1 ? B HIS 60 ? B HIS 80 ? 1_555 ZN ? L ZN . ? B ZN 402 ? 1_555 O3 ? P PO4 . ? B PO4 601 ? 1_555 151.5 ? 53 NE2 ? B HIS 115 ? B HIS 135 ? 1_555 ZN ? L ZN . ? B ZN 402 ? 1_555 O3 ? P PO4 . ? B PO4 601 ? 1_555 98.1 ? 54 OD2 ? B ASP 119 ? B ASP 139 ? 1_555 ZN ? L ZN . ? B ZN 402 ? 1_555 O3 ? P PO4 . ? B PO4 601 ? 1_555 105.1 ? 55 O1 ? P PO4 . ? B PO4 601 ? 1_555 ZN ? L ZN . ? B ZN 402 ? 1_555 O3 ? P PO4 . ? B PO4 601 ? 1_555 66.1 ? 56 NE2 ? B HIS 125 ? B HIS 145 ? 1_555 ZN ? M ZN . ? B ZN 403 ? 1_555 NE2 ? B HIS 148 ? B HIS 168 ? 1_555 96.7 ? 57 NE2 ? B HIS 125 ? B HIS 145 ? 1_555 ZN ? M ZN . ? B ZN 403 ? 1_555 OD1 ? B ASP 152 ? B ASP 172 ? 1_555 92.2 ? 58 NE2 ? B HIS 148 ? B HIS 168 ? 1_555 ZN ? M ZN . ? B ZN 403 ? 1_555 OD1 ? B ASP 152 ? B ASP 172 ? 1_555 89.9 ? 59 NE2 ? B HIS 125 ? B HIS 145 ? 1_555 ZN ? M ZN . ? B ZN 403 ? 1_555 OD2 ? B ASP 152 ? B ASP 172 ? 1_555 144.2 ? 60 NE2 ? B HIS 148 ? B HIS 168 ? 1_555 ZN ? M ZN . ? B ZN 403 ? 1_555 OD2 ? B ASP 152 ? B ASP 172 ? 1_555 92.5 ? 61 OD1 ? B ASP 152 ? B ASP 172 ? 1_555 ZN ? M ZN . ? B ZN 403 ? 1_555 OD2 ? B ASP 152 ? B ASP 172 ? 1_555 53.1 ? 62 NE2 ? B HIS 125 ? B HIS 145 ? 1_555 ZN ? M ZN . ? B ZN 403 ? 1_555 O ? S HOH . ? B HOH 1034 ? 1_555 113.3 ? 63 NE2 ? B HIS 148 ? B HIS 168 ? 1_555 ZN ? M ZN . ? B ZN 403 ? 1_555 O ? S HOH . ? B HOH 1034 ? 1_555 84.3 ? 64 OD1 ? B ASP 152 ? B ASP 172 ? 1_555 ZN ? M ZN . ? B ZN 403 ? 1_555 O ? S HOH . ? B HOH 1034 ? 1_555 154.3 ? 65 OD2 ? B ASP 152 ? B ASP 172 ? 1_555 ZN ? M ZN . ? B ZN 403 ? 1_555 O ? S HOH . ? B HOH 1034 ? 1_555 102.0 ? 66 NE2 ? B HIS 125 ? B HIS 145 ? 1_555 ZN ? M ZN . ? B ZN 403 ? 1_555 O2 ? P PO4 . ? B PO4 601 ? 1_555 89.6 ? 67 NE2 ? B HIS 148 ? B HIS 168 ? 1_555 ZN ? M ZN . ? B ZN 403 ? 1_555 O2 ? P PO4 . ? B PO4 601 ? 1_555 169.7 ? 68 OD1 ? B ASP 152 ? B ASP 172 ? 1_555 ZN ? M ZN . ? B ZN 403 ? 1_555 O2 ? P PO4 . ? B PO4 601 ? 1_555 98.1 ? 69 OD2 ? B ASP 152 ? B ASP 172 ? 1_555 ZN ? M ZN . ? B ZN 403 ? 1_555 O2 ? P PO4 . ? B PO4 601 ? 1_555 87.1 ? 70 O ? S HOH . ? B HOH 1034 ? 1_555 ZN ? M ZN . ? B ZN 403 ? 1_555 O2 ? P PO4 . ? B PO4 601 ? 1_555 85.7 ? # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2016-12-28 2 'Structure model' 1 1 2017-01-11 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # _pdbx_audit_revision_group.ordinal 1 _pdbx_audit_revision_group.revision_ordinal 2 _pdbx_audit_revision_group.data_content_type 'Structure model' _pdbx_audit_revision_group.group 'Database references' # loop_ _software.citation_id _software.classification _software.compiler_name _software.compiler_version _software.contact_author _software.contact_author_email _software.date _software.description _software.dependencies _software.hardware _software.language _software.location _software.mods _software.name _software.os _software.os_version _software.type _software.version _software.pdbx_ordinal ? refinement ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0131 1 ? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? iMOSFLM ? ? ? . 2 ? 'data scaling' ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? . 3 ? phasing ? ? ? ? ? ? ? ? ? ? ? MOLREP ? ? ? . 4 ? 'model building' ? ? ? ? ? ? ? ? ? ? ? Coot ? ? ? . 5 # loop_ _pdbx_validate_rmsd_angle.id _pdbx_validate_rmsd_angle.PDB_model_num _pdbx_validate_rmsd_angle.auth_atom_id_1 _pdbx_validate_rmsd_angle.auth_asym_id_1 _pdbx_validate_rmsd_angle.auth_comp_id_1 _pdbx_validate_rmsd_angle.auth_seq_id_1 _pdbx_validate_rmsd_angle.PDB_ins_code_1 _pdbx_validate_rmsd_angle.label_alt_id_1 _pdbx_validate_rmsd_angle.auth_atom_id_2 _pdbx_validate_rmsd_angle.auth_asym_id_2 _pdbx_validate_rmsd_angle.auth_comp_id_2 _pdbx_validate_rmsd_angle.auth_seq_id_2 _pdbx_validate_rmsd_angle.PDB_ins_code_2 _pdbx_validate_rmsd_angle.label_alt_id_2 _pdbx_validate_rmsd_angle.auth_atom_id_3 _pdbx_validate_rmsd_angle.auth_asym_id_3 _pdbx_validate_rmsd_angle.auth_comp_id_3 _pdbx_validate_rmsd_angle.auth_seq_id_3 _pdbx_validate_rmsd_angle.PDB_ins_code_3 _pdbx_validate_rmsd_angle.label_alt_id_3 _pdbx_validate_rmsd_angle.angle_value _pdbx_validate_rmsd_angle.angle_target_value _pdbx_validate_rmsd_angle.angle_deviation _pdbx_validate_rmsd_angle.angle_standard_deviation _pdbx_validate_rmsd_angle.linker_flag 1 1 CB B ASP 95 ? ? CG B ASP 95 ? ? OD2 B ASP 95 ? ? 112.14 118.30 -6.16 0.90 N 2 1 CB B ASP 172 ? ? CG B ASP 172 ? ? OD1 B ASP 172 ? ? 124.09 118.30 5.79 0.90 N 3 1 CB B ASP 230 ? ? CG B ASP 230 ? ? OD1 B ASP 230 ? ? 125.77 118.30 7.47 0.90 N # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 ASP A 86 ? ? -105.80 -160.38 2 1 SER A 120 ? ? -150.97 61.49 3 1 THR A 165 ? ? -156.26 -152.80 4 1 THR A 173 ? ? -135.57 -64.00 5 1 TYR A 183 ? ? -141.19 -6.08 6 1 THR A 238 ? ? -136.12 -50.40 7 1 ASP B 86 ? ? -108.79 -162.13 8 1 SER B 120 ? ? -149.15 56.89 9 1 THR B 165 ? ? -150.46 -153.38 10 1 THR B 173 ? ? -133.91 -65.90 11 1 TYR B 183 ? ? -140.06 -6.43 12 1 THR B 238 ? ? -134.65 -50.48 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 B PRO 286 ? B PRO 266 2 1 Y 1 B SER 287 ? B SER 267 # loop_ _pdbx_audit_support.funding_organization _pdbx_audit_support.country _pdbx_audit_support.grant_number _pdbx_audit_support.ordinal 'Ministry of Education, Youth and Sports of the Czech Republic' 'Czech Republic' LG14009 1 ;BIOCEV: Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University from the European Regional Development Fund ; 'Czech Republic' CZ.1.05/1.1.00/02.0109 2 'European Community' ? 283570/8787 3 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 'ZINC ION' ZN 3 N-ACETYL-D-GLUCOSAMINE NAG 4 'PHOSPHATE ION' PO4 5 "2'-DEOXYCYTIDINE" DCZ 6 "2'-DEOXY-GUANOSINE" GNG 7 water HOH #