data_4XX4 # _entry.id 4XX4 # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.292 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 4XX4 WWPDB D_1000206450 # _pdbx_database_related.content_type unspecified _pdbx_database_related.db_id 4XX3 _pdbx_database_related.db_name PDB _pdbx_database_related.details . # _pdbx_database_status.status_code REL _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.entry_id 4XX4 _pdbx_database_status.recvd_initial_deposition_date 2015-01-29 _pdbx_database_status.SG_entry N _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? _pdbx_database_status.pdb_format_compatible Y # _audit_author.name 'Orth, P.' _audit_author.pdbx_ordinal 1 # _citation.abstract ? _citation.abstract_id_CAS ? _citation.book_id_ISBN ? _citation.book_publisher ? _citation.book_publisher_city ? _citation.book_title ? _citation.coordinate_linkage ? _citation.country UK _citation.database_id_Medline ? _citation.details ? _citation.id primary _citation.journal_abbrev 'Bioorg. Med. Chem. Lett.' _citation.journal_id_ASTM BMCLE8 _citation.journal_id_CSD 1127 _citation.journal_id_ISSN 1464-3405 _citation.journal_full ? _citation.journal_issue ? _citation.journal_volume 25 _citation.language ? _citation.page_first 1592 _citation.page_last 1596 _citation.title 'Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.' _citation.year 2015 _citation.database_id_CSD ? _citation.pdbx_database_id_DOI 10.1016/j.bmcl.2015.02.003 _citation.pdbx_database_id_PubMed 25728416 _citation.unpublished_flag ? # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'McKittrick, B.A.' 1 primary 'Caldwell, J.P.' 2 primary 'Bara, T.' 3 primary 'Boykow, G.' 4 primary 'Chintala, M.' 5 primary 'Clader, J.' 6 primary 'Czarniecki, M.' 7 primary 'Courneya, B.' 8 primary 'Duffy, R.' 9 primary 'Fleming, L.' 10 primary 'Giessert, R.' 11 primary 'Greenlee, W.J.' 12 primary 'Heap, C.' 13 primary 'Hong, L.' 14 primary 'Huang, Y.' 15 primary 'Iserloh, U.' 16 primary 'Josien, H.' 17 primary 'Khan, T.' 18 primary 'Korfmacher, W.' 19 primary 'Liang, X.' 20 primary 'Mazzola, R.' 21 primary 'Mitra, S.' 22 primary 'Moore, K.' 23 primary 'Orth, P.' 24 primary 'Rajagopalan, M.' 25 primary 'Roy, S.' 26 primary 'Sakwa, S.' 27 primary 'Strickland, C.' 28 primary 'Vaccaro, H.' 29 primary 'Voigt, J.' 30 primary 'Wang, H.' 31 primary 'Wong, J.' 32 primary 'Zhang, R.' 33 primary 'Zych, A.' 34 # _cell.angle_alpha 90.000 _cell.angle_alpha_esd ? _cell.angle_beta 90.000 _cell.angle_beta_esd ? _cell.angle_gamma 90.000 _cell.angle_gamma_esd ? _cell.entry_id 4XX4 _cell.details ? _cell.formula_units_Z ? _cell.length_a 142.410 _cell.length_a_esd ? _cell.length_b 142.410 _cell.length_b_esd ? _cell.length_c 142.410 _cell.length_c_esd ? _cell.volume ? _cell.volume_esd ? _cell.Z_PDB 24 _cell.reciprocal_angle_alpha ? _cell.reciprocal_angle_beta ? _cell.reciprocal_angle_gamma ? _cell.reciprocal_angle_alpha_esd ? _cell.reciprocal_angle_beta_esd ? _cell.reciprocal_angle_gamma_esd ? _cell.reciprocal_length_a ? _cell.reciprocal_length_b ? _cell.reciprocal_length_c ? _cell.reciprocal_length_a_esd ? _cell.reciprocal_length_b_esd ? _cell.reciprocal_length_c_esd ? _cell.pdbx_unique_axis ? # _symmetry.entry_id 4XX4 _symmetry.cell_setting ? _symmetry.Int_Tables_number 198 _symmetry.space_group_name_Hall ? _symmetry.space_group_name_H-M 'P 21 3' _symmetry.pdbx_full_space_group_name_H-M ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man Renin 37267.008 2 3.4.23.15 ? ? ;LTLG NTTSSVILTN YMDTQYYGEI GIGTPPQTFK VVFDTGSSNV WVPSSKCSRL YTACVYHKLF DASDSSSYKH NGTELTLRYS TGTVSGFLSQ DIITVGGITV TQMFGEVTEM PALPFMLAEF DGVVGMGFIE QAIGRVTPIF DNIISQGVLK EDVFSFYYNR DSENSQSLGG QIVLGGSDPQ HYEGNFHYIN LIKTGVWQIQ MKGVSVGSST LLCEDGCLAL VDTGASYISG STSSIEKLME ALGAKKRLFD YVVKCNEGPT LPDISFHLGG KEYTLTSADY VFQESYSSKK LCTLAIHAMD IPPPTGPTWA LGATFIRKFY TEFDRRNNRI GFALAR ; 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 1 ? ? ? ? 3 non-polymer syn '(2Z,6S)-2-imino-6-methyl-3-{3-[(4R)-2-oxo-4-phenylpyrrolidin-1-yl]benzyl}-6-(propan-2-yl)tetrahydropyrimidin-4(1H)-one' 418.531 2 ? ? ? ? 4 water nat water 18.015 207 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name Angiotensinogenase # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELT LRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF YYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE KLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFI RKFYTEFDRRNNRIGFALAR ; _entity_poly.pdbx_seq_one_letter_code_can ;LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELT LRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF YYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE KLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFI RKFYTEFDRRNNRIGFALAR ; _entity_poly.pdbx_strand_id A,B _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 LEU n 1 2 THR n 1 3 LEU n 1 4 GLY n 1 5 ASN n 1 6 THR n 1 7 THR n 1 8 SER n 1 9 SER n 1 10 VAL n 1 11 ILE n 1 12 LEU n 1 13 THR n 1 14 ASN n 1 15 TYR n 1 16 MET n 1 17 ASP n 1 18 THR n 1 19 GLN n 1 20 TYR n 1 21 TYR n 1 22 GLY n 1 23 GLU n 1 24 ILE n 1 25 GLY n 1 26 ILE n 1 27 GLY n 1 28 THR n 1 29 PRO n 1 30 PRO n 1 31 GLN n 1 32 THR n 1 33 PHE n 1 34 LYS n 1 35 VAL n 1 36 VAL n 1 37 PHE n 1 38 ASP n 1 39 THR n 1 40 GLY n 1 41 SER n 1 42 SER n 1 43 ASN n 1 44 VAL n 1 45 TRP n 1 46 VAL n 1 47 PRO n 1 48 SER n 1 49 SER n 1 50 LYS n 1 51 CYS n 1 52 SER n 1 53 ARG n 1 54 LEU n 1 55 TYR n 1 56 THR n 1 57 ALA n 1 58 CYS n 1 59 VAL n 1 60 TYR n 1 61 HIS n 1 62 LYS n 1 63 LEU n 1 64 PHE n 1 65 ASP n 1 66 ALA n 1 67 SER n 1 68 ASP n 1 69 SER n 1 70 SER n 1 71 SER n 1 72 TYR n 1 73 LYS n 1 74 HIS n 1 75 ASN n 1 76 GLY n 1 77 THR n 1 78 GLU n 1 79 LEU n 1 80 THR n 1 81 LEU n 1 82 ARG n 1 83 TYR n 1 84 SER n 1 85 THR n 1 86 GLY n 1 87 THR n 1 88 VAL n 1 89 SER n 1 90 GLY n 1 91 PHE n 1 92 LEU n 1 93 SER n 1 94 GLN n 1 95 ASP n 1 96 ILE n 1 97 ILE n 1 98 THR n 1 99 VAL n 1 100 GLY n 1 101 GLY n 1 102 ILE n 1 103 THR n 1 104 VAL n 1 105 THR n 1 106 GLN n 1 107 MET n 1 108 PHE n 1 109 GLY n 1 110 GLU n 1 111 VAL n 1 112 THR n 1 113 GLU n 1 114 MET n 1 115 PRO n 1 116 ALA n 1 117 LEU n 1 118 PRO n 1 119 PHE n 1 120 MET n 1 121 LEU n 1 122 ALA n 1 123 GLU n 1 124 PHE n 1 125 ASP n 1 126 GLY n 1 127 VAL n 1 128 VAL n 1 129 GLY n 1 130 MET n 1 131 GLY n 1 132 PHE n 1 133 ILE n 1 134 GLU n 1 135 GLN n 1 136 ALA n 1 137 ILE n 1 138 GLY n 1 139 ARG n 1 140 VAL n 1 141 THR n 1 142 PRO n 1 143 ILE n 1 144 PHE n 1 145 ASP n 1 146 ASN n 1 147 ILE n 1 148 ILE n 1 149 SER n 1 150 GLN n 1 151 GLY n 1 152 VAL n 1 153 LEU n 1 154 LYS n 1 155 GLU n 1 156 ASP n 1 157 VAL n 1 158 PHE n 1 159 SER n 1 160 PHE n 1 161 TYR n 1 162 TYR n 1 163 ASN n 1 164 ARG n 1 165 ASP n 1 166 SER n 1 167 GLU n 1 168 ASN n 1 169 SER n 1 170 GLN n 1 171 SER n 1 172 LEU n 1 173 GLY n 1 174 GLY n 1 175 GLN n 1 176 ILE n 1 177 VAL n 1 178 LEU n 1 179 GLY n 1 180 GLY n 1 181 SER n 1 182 ASP n 1 183 PRO n 1 184 GLN n 1 185 HIS n 1 186 TYR n 1 187 GLU n 1 188 GLY n 1 189 ASN n 1 190 PHE n 1 191 HIS n 1 192 TYR n 1 193 ILE n 1 194 ASN n 1 195 LEU n 1 196 ILE n 1 197 LYS n 1 198 THR n 1 199 GLY n 1 200 VAL n 1 201 TRP n 1 202 GLN n 1 203 ILE n 1 204 GLN n 1 205 MET n 1 206 LYS n 1 207 GLY n 1 208 VAL n 1 209 SER n 1 210 VAL n 1 211 GLY n 1 212 SER n 1 213 SER n 1 214 THR n 1 215 LEU n 1 216 LEU n 1 217 CYS n 1 218 GLU n 1 219 ASP n 1 220 GLY n 1 221 CYS n 1 222 LEU n 1 223 ALA n 1 224 LEU n 1 225 VAL n 1 226 ASP n 1 227 THR n 1 228 GLY n 1 229 ALA n 1 230 SER n 1 231 TYR n 1 232 ILE n 1 233 SER n 1 234 GLY n 1 235 SER n 1 236 THR n 1 237 SER n 1 238 SER n 1 239 ILE n 1 240 GLU n 1 241 LYS n 1 242 LEU n 1 243 MET n 1 244 GLU n 1 245 ALA n 1 246 LEU n 1 247 GLY n 1 248 ALA n 1 249 LYS n 1 250 LYS n 1 251 ARG n 1 252 LEU n 1 253 PHE n 1 254 ASP n 1 255 TYR n 1 256 VAL n 1 257 VAL n 1 258 LYS n 1 259 CYS n 1 260 ASN n 1 261 GLU n 1 262 GLY n 1 263 PRO n 1 264 THR n 1 265 LEU n 1 266 PRO n 1 267 ASP n 1 268 ILE n 1 269 SER n 1 270 PHE n 1 271 HIS n 1 272 LEU n 1 273 GLY n 1 274 GLY n 1 275 LYS n 1 276 GLU n 1 277 TYR n 1 278 THR n 1 279 LEU n 1 280 THR n 1 281 SER n 1 282 ALA n 1 283 ASP n 1 284 TYR n 1 285 VAL n 1 286 PHE n 1 287 GLN n 1 288 GLU n 1 289 SER n 1 290 TYR n 1 291 SER n 1 292 SER n 1 293 LYS n 1 294 LYS n 1 295 LEU n 1 296 CYS n 1 297 THR n 1 298 LEU n 1 299 ALA n 1 300 ILE n 1 301 HIS n 1 302 ALA n 1 303 MET n 1 304 ASP n 1 305 ILE n 1 306 PRO n 1 307 PRO n 1 308 PRO n 1 309 THR n 1 310 GLY n 1 311 PRO n 1 312 THR n 1 313 TRP n 1 314 ALA n 1 315 LEU n 1 316 GLY n 1 317 ALA n 1 318 THR n 1 319 PHE n 1 320 ILE n 1 321 ARG n 1 322 LYS n 1 323 PHE n 1 324 TYR n 1 325 THR n 1 326 GLU n 1 327 PHE n 1 328 ASP n 1 329 ARG n 1 330 ARG n 1 331 ASN n 1 332 ASN n 1 333 ARG n 1 334 ILE n 1 335 GLY n 1 336 PHE n 1 337 ALA n 1 338 LEU n 1 339 ALA n 1 340 ARG n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type 'Biological sequence' _entity_src_gen.pdbx_beg_seq_num 1 _entity_src_gen.pdbx_end_seq_num 340 _entity_src_gen.gene_src_common_name Human _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene REN _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Homo sapiens' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 9606 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'Homo sapiens' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 9606 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain ? _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line '293 HEK' _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type ? _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name ? _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code RENI_HUMAN _struct_ref.pdbx_db_accession P00797 _struct_ref.pdbx_db_isoform ? _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELT LRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF YYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE KLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFI RKFYTEFDRRNNRIGFALAR ; _struct_ref.pdbx_align_begin 67 # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 4XX4 A 1 ? 340 ? P00797 67 ? 406 ? 67 406 2 1 4XX4 B 1 ? 340 ? P00797 67 ? 406 ? 67 406 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight 70Y non-polymer . '(2Z,6S)-2-imino-6-methyl-3-{3-[(4R)-2-oxo-4-phenylpyrrolidin-1-yl]benzyl}-6-(propan-2-yl)tetrahydropyrimidin-4(1H)-one' ? 'C25 H30 N4 O2' 418.531 ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.absorpt_coefficient_mu ? _exptl.absorpt_correction_T_max ? _exptl.absorpt_correction_T_min ? _exptl.absorpt_correction_type ? _exptl.absorpt_process_details ? _exptl.entry_id 4XX4 _exptl.crystals_number 1 _exptl.details ? _exptl.method 'X-RAY DIFFRACTION' _exptl.method_details ? # _exptl_crystal.colour ? _exptl_crystal.density_diffrn ? _exptl_crystal.density_Matthews 3.25 _exptl_crystal.density_method ? _exptl_crystal.density_percent_sol 62.17 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.id 1 _exptl_crystal.preparation ? _exptl_crystal.size_max ? _exptl_crystal.size_mid ? _exptl_crystal.size_min ? _exptl_crystal.size_rad ? _exptl_crystal.colour_lustre ? _exptl_crystal.colour_modifier ? _exptl_crystal.colour_primary ? _exptl_crystal.density_meas ? _exptl_crystal.density_meas_esd ? _exptl_crystal.density_meas_gt ? _exptl_crystal.density_meas_lt ? _exptl_crystal.density_meas_temp ? _exptl_crystal.density_meas_temp_esd ? _exptl_crystal.density_meas_temp_gt ? _exptl_crystal.density_meas_temp_lt ? _exptl_crystal.pdbx_crystal_image_url ? _exptl_crystal.pdbx_crystal_image_format ? _exptl_crystal.pdbx_mosaicity ? _exptl_crystal.pdbx_mosaicity_esd ? # _exptl_crystal_grow.apparatus ? _exptl_crystal_grow.atmosphere ? _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.details ? _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.method_ref ? _exptl_crystal_grow.pH ? _exptl_crystal_grow.pressure ? _exptl_crystal_grow.pressure_esd ? _exptl_crystal_grow.seeding ? _exptl_crystal_grow.seeding_ref ? _exptl_crystal_grow.temp 295 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.temp_esd ? _exptl_crystal_grow.time ? _exptl_crystal_grow.pdbx_details '15% PEG3350, 625 mM NaCl and citrate buffer pH 4.6' _exptl_crystal_grow.pdbx_pH_range ? # _diffrn.ambient_environment ? _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.ambient_temp_esd ? _diffrn.crystal_id 1 _diffrn.crystal_support ? _diffrn.crystal_treatment ? _diffrn.details ? _diffrn.id 1 _diffrn.ambient_pressure ? _diffrn.ambient_pressure_esd ? _diffrn.ambient_pressure_gt ? _diffrn.ambient_pressure_lt ? _diffrn.ambient_temp_gt ? _diffrn.ambient_temp_lt ? # _diffrn_detector.details ? _diffrn_detector.detector 'IMAGE PLATE' _diffrn_detector.diffrn_id 1 _diffrn_detector.type 'RIGAKU RAXIS IV' _diffrn_detector.area_resol_mean ? _diffrn_detector.dtime ? _diffrn_detector.pdbx_frames_total ? _diffrn_detector.pdbx_collection_time_total ? _diffrn_detector.pdbx_collection_date 2009-05-26 # _diffrn_radiation.collimation ? _diffrn_radiation.diffrn_id 1 _diffrn_radiation.filter_edge ? _diffrn_radiation.inhomogeneity ? _diffrn_radiation.monochromator ? _diffrn_radiation.polarisn_norm ? _diffrn_radiation.polarisn_ratio ? _diffrn_radiation.probe ? _diffrn_radiation.type ? _diffrn_radiation.xray_symbol ? _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.pdbx_wavelength_list ? _diffrn_radiation.pdbx_wavelength ? _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_analyzer ? _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 1.54178 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.current ? _diffrn_source.details ? _diffrn_source.diffrn_id 1 _diffrn_source.power ? _diffrn_source.size ? _diffrn_source.source 'ROTATING ANODE' _diffrn_source.target ? _diffrn_source.type 'RIGAKU FR-E DW' _diffrn_source.voltage ? _diffrn_source.take-off_angle ? _diffrn_source.pdbx_wavelength_list 1.54178 _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_synchrotron_beamline ? _diffrn_source.pdbx_synchrotron_site ? # _reflns.B_iso_Wilson_estimate ? _reflns.entry_id 4XX4 _reflns.data_reduction_details ? _reflns.data_reduction_method ? _reflns.d_resolution_high 2.400 _reflns.d_resolution_low 20.000 _reflns.details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.number_all ? _reflns.number_obs 36079 _reflns.observed_criterion ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.observed_criterion_I_max ? _reflns.observed_criterion_I_min ? _reflns.observed_criterion_sigma_F ? _reflns.observed_criterion_sigma_I ? _reflns.percent_possible_obs 95.500 _reflns.R_free_details ? _reflns.Rmerge_F_all ? _reflns.Rmerge_F_obs ? _reflns.Friedel_coverage ? _reflns.number_gt ? _reflns.threshold_expression ? _reflns.pdbx_redundancy 3.000 _reflns.pdbx_Rmerge_I_obs 0.090 _reflns.pdbx_Rmerge_I_all ? _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_av_sigmaI 7.891 _reflns.pdbx_netI_over_sigmaI 17.900 _reflns.pdbx_res_netI_over_av_sigmaI_2 ? _reflns.pdbx_res_netI_over_sigmaI_2 ? _reflns.pdbx_chi_squared 1.065 _reflns.pdbx_scaling_rejects ? _reflns.pdbx_d_res_high_opt ? _reflns.pdbx_d_res_low_opt ? _reflns.pdbx_d_res_opt_method ? _reflns.phase_calculation_details ? _reflns.pdbx_Rrim_I_all ? _reflns.pdbx_Rpim_I_all ? _reflns.pdbx_d_opt ? _reflns.pdbx_number_measured_all 108629 _reflns.pdbx_diffrn_id 1 _reflns.pdbx_ordinal 1 _reflns.pdbx_CC_half ? _reflns.pdbx_R_split ? # loop_ _reflns_shell.d_res_high _reflns_shell.d_res_low _reflns_shell.meanI_over_sigI_all _reflns_shell.meanI_over_sigI_obs _reflns_shell.number_measured_all _reflns_shell.number_measured_obs _reflns_shell.number_possible _reflns_shell.number_unique_all _reflns_shell.number_unique_obs _reflns_shell.percent_possible_all _reflns_shell.percent_possible_obs _reflns_shell.Rmerge_F_all _reflns_shell.Rmerge_F_obs _reflns_shell.Rmerge_I_all _reflns_shell.Rmerge_I_obs _reflns_shell.meanI_over_sigI_gt _reflns_shell.meanI_over_uI_all _reflns_shell.meanI_over_uI_gt _reflns_shell.number_measured_gt _reflns_shell.number_unique_gt _reflns_shell.percent_possible_gt _reflns_shell.Rmerge_F_gt _reflns_shell.Rmerge_I_gt _reflns_shell.pdbx_redundancy _reflns_shell.pdbx_Rsym_value _reflns_shell.pdbx_chi_squared _reflns_shell.pdbx_netI_over_sigmaI_all _reflns_shell.pdbx_netI_over_sigmaI_obs _reflns_shell.pdbx_Rrim_I_all _reflns_shell.pdbx_Rpim_I_all _reflns_shell.pdbx_rejects _reflns_shell.pdbx_ordinal _reflns_shell.pdbx_diffrn_id _reflns_shell.pdbx_CC_half _reflns_shell.pdbx_R_split 2.400 2.490 ? ? ? ? ? 3485 ? 92.400 ? ? ? ? 0.428 ? ? ? ? ? ? ? ? 2.400 ? 1.127 ? ? ? ? ? 1 1 ? ? 2.490 2.580 ? ? ? ? ? 3385 ? 91.300 ? ? ? ? 0.335 ? ? ? ? ? ? ? ? 2.600 ? 1.097 ? ? ? ? ? 2 ? ? ? 2.580 2.700 ? ? ? ? ? 3430 ? 92.000 ? ? ? ? 0.254 ? ? ? ? ? ? ? ? 2.700 ? 1.066 ? ? ? ? ? 3 ? ? ? 2.700 2.840 ? ? ? ? ? 3524 ? 94.200 ? ? ? ? 0.196 ? ? ? ? ? ? ? ? 2.800 ? 1.064 ? ? ? ? ? 4 ? ? ? 2.840 3.020 ? ? ? ? ? 3641 ? 97.300 ? ? ? ? 0.153 ? ? ? ? ? ? ? ? 3.000 ? 1.098 ? ? ? ? ? 5 ? ? ? 3.020 3.250 ? ? ? ? ? 3750 ? 99.300 ? ? ? ? 0.125 ? ? ? ? ? ? ? ? 3.200 ? 1.077 ? ? ? ? ? 6 ? ? ? 3.250 3.580 ? ? ? ? ? 3743 ? 99.500 ? ? ? ? 0.102 ? ? ? ? ? ? ? ? 3.300 ? 1.044 ? ? ? ? ? 7 ? ? ? 3.580 4.090 ? ? ? ? ? 3750 ? 99.100 ? ? ? ? 0.086 ? ? ? ? ? ? ? ? 3.300 ? 1.019 ? ? ? ? ? 8 ? ? ? 4.090 5.140 ? 10.0 ? ? ? 3713 ? 97.200 ? ? ? ? 0.074 ? ? ? ? ? ? ? ? 3.300 ? 1.017 ? ? ? ? ? 9 ? ? ? 5.140 20.000 ? 10.0 ? ? ? 3658 ? 92.900 ? ? ? ? 0.059 ? ? ? ? ? ? ? ? 3.400 ? 1.079 ? ? ? ? ? 10 ? ? ? # _refine.aniso_B[1][1] 0.0000 _refine.aniso_B[1][2] 0.0000 _refine.aniso_B[1][3] 0.0000 _refine.aniso_B[2][2] 0.0000 _refine.aniso_B[2][3] 0.0000 _refine.aniso_B[3][3] 0.0000 _refine.B_iso_max 122.730 _refine.B_iso_mean 46.9442 _refine.B_iso_min 23.130 _refine.correlation_coeff_Fo_to_Fc 0.9406 _refine.correlation_coeff_Fo_to_Fc_free 0.9366 _refine.details ? _refine.diff_density_max ? _refine.diff_density_max_esd ? _refine.diff_density_min ? _refine.diff_density_min_esd ? _refine.diff_density_rms ? _refine.diff_density_rms_esd ? _refine.entry_id 4XX4 _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.ls_abs_structure_details ? _refine.ls_abs_structure_Flack ? _refine.ls_abs_structure_Flack_esd ? _refine.ls_abs_structure_Rogers ? _refine.ls_abs_structure_Rogers_esd ? _refine.ls_d_res_high 2.4000 _refine.ls_d_res_low 19.9400 _refine.ls_extinction_coef ? _refine.ls_extinction_coef_esd ? _refine.ls_extinction_expression ? _refine.ls_extinction_method ? _refine.ls_goodness_of_fit_all ? _refine.ls_goodness_of_fit_all_esd ? _refine.ls_goodness_of_fit_obs ? _refine.ls_goodness_of_fit_obs_esd ? _refine.ls_hydrogen_treatment ? _refine.ls_matrix_type ? _refine.ls_number_constraints ? _refine.ls_number_parameters ? _refine.ls_number_reflns_all ? _refine.ls_number_reflns_obs 35898 _refine.ls_number_reflns_R_free 1379 _refine.ls_number_reflns_R_work ? _refine.ls_number_restraints ? _refine.ls_percent_reflns_obs 95.1100 _refine.ls_percent_reflns_R_free 3.8400 _refine.ls_R_factor_all ? _refine.ls_R_factor_obs 0.2105 _refine.ls_R_factor_R_free 0.2293 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_R_factor_R_work 0.2098 _refine.ls_R_Fsqd_factor_obs ? _refine.ls_R_I_factor_obs ? _refine.ls_redundancy_reflns_all ? _refine.ls_redundancy_reflns_obs ? _refine.ls_restrained_S_all ? _refine.ls_restrained_S_obs ? _refine.ls_shift_over_esd_max ? _refine.ls_shift_over_esd_mean ? _refine.ls_structure_factor_coef ? _refine.ls_weighting_details ? _refine.ls_weighting_scheme ? _refine.ls_wR_factor_all ? _refine.ls_wR_factor_obs ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.occupancy_max 1.000 _refine.occupancy_min 0.500 _refine.solvent_model_details ? _refine.solvent_model_param_bsol ? _refine.solvent_model_param_ksol ? _refine.ls_R_factor_gt ? _refine.ls_goodness_of_fit_gt ? _refine.ls_goodness_of_fit_ref ? _refine.ls_shift_over_su_max ? _refine.ls_shift_over_su_max_lt ? _refine.ls_shift_over_su_mean ? _refine.ls_shift_over_su_mean_lt ? _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F 0.000 _refine.pdbx_ls_sigma_Fsqd ? _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_starting_model 'PDB entry 2I4Q' _refine.pdbx_stereochemistry_target_values ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_overall_ESU_R ? _refine.pdbx_overall_ESU_R_Free ? _refine.pdbx_solvent_vdw_probe_radii ? _refine.pdbx_solvent_ion_probe_radii ? _refine.pdbx_solvent_shrinkage_radii ? _refine.pdbx_real_space_R ? _refine.pdbx_density_correlation ? _refine.pdbx_pd_number_of_powder_patterns ? _refine.pdbx_pd_number_of_points ? _refine.pdbx_pd_meas_number_of_points ? _refine.pdbx_pd_proc_ls_prof_R_factor ? _refine.pdbx_pd_proc_ls_prof_wR_factor ? _refine.pdbx_pd_Marquardt_correlation_coeff ? _refine.pdbx_pd_Fsqrd_R_factor ? _refine.pdbx_pd_ls_matrix_band_width ? _refine.pdbx_overall_phase_error ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_diffrn_id 1 _refine.overall_SU_B ? _refine.overall_SU_ML ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_average_fsc_overall ? _refine.pdbx_average_fsc_work ? _refine.pdbx_average_fsc_free ? # _refine_analyze.entry_id 4XX4 _refine_analyze.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_analyze.Luzzati_coordinate_error_free ? _refine_analyze.Luzzati_coordinate_error_obs 0.350 _refine_analyze.Luzzati_d_res_low_free ? _refine_analyze.Luzzati_d_res_low_obs ? _refine_analyze.Luzzati_sigma_a_free ? _refine_analyze.Luzzati_sigma_a_free_details ? _refine_analyze.Luzzati_sigma_a_obs ? _refine_analyze.Luzzati_sigma_a_obs_details ? _refine_analyze.number_disordered_residues ? _refine_analyze.occupancy_sum_hydrogen ? _refine_analyze.occupancy_sum_non_hydrogen ? _refine_analyze.RG_d_res_high ? _refine_analyze.RG_d_res_low ? _refine_analyze.RG_free ? _refine_analyze.RG_work ? _refine_analyze.RG_free_work_ratio ? _refine_analyze.pdbx_Luzzati_d_res_high_obs ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 5120 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 76 _refine_hist.number_atoms_solvent 207 _refine_hist.number_atoms_total 5403 _refine_hist.d_res_high 2.4000 _refine_hist.d_res_low 19.9400 # loop_ _refine_ls_restr.pdbx_refine_id _refine_ls_restr.criterion _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.number _refine_ls_restr.rejects _refine_ls_restr.type _refine_ls_restr.weight _refine_ls_restr.pdbx_restraint_function 'X-RAY DIFFRACTION' ? ? ? 1725 ? t_dihedral_angle_d 2.000 SINUSOIDAL 'X-RAY DIFFRACTION' ? ? ? 108 ? t_trig_c_planes 2.000 HARMONIC 'X-RAY DIFFRACTION' ? ? ? 807 ? t_gen_planes 5.000 HARMONIC 'X-RAY DIFFRACTION' ? ? ? 5336 ? t_it 20.000 HARMONIC 'X-RAY DIFFRACTION' ? ? ? ? ? t_nbd ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? t_improper_torsion ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? t_pseud_angle ? ? 'X-RAY DIFFRACTION' ? ? ? 718 ? t_chiral_improper_torsion 5.000 SEMIHARMONIC 'X-RAY DIFFRACTION' ? ? ? ? ? t_sum_occupancies ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? t_utility_distance ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? t_utility_angle ? ? 'X-RAY DIFFRACTION' ? ? ? ? ? t_utility_torsion ? ? 'X-RAY DIFFRACTION' ? ? ? 5919 ? t_ideal_dist_contact 4.000 SEMIHARMONIC 'X-RAY DIFFRACTION' ? 0.010 ? 5336 ? t_bond_d 2.000 HARMONIC 'X-RAY DIFFRACTION' ? 1.200 ? 7275 ? t_angle_deg 2.000 HARMONIC 'X-RAY DIFFRACTION' ? 3.710 ? ? ? t_omega_torsion ? ? 'X-RAY DIFFRACTION' ? 17.040 ? ? ? t_other_torsion ? ? # _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_ls_shell.d_res_high 2.4000 _refine_ls_shell.d_res_low 2.4700 _refine_ls_shell.number_reflns_all 2776 _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.number_reflns_R_free 112 _refine_ls_shell.number_reflns_R_work 2664 _refine_ls_shell.percent_reflns_obs 95.1100 _refine_ls_shell.percent_reflns_R_free 4.0300 _refine_ls_shell.R_factor_all 0.2589 _refine_ls_shell.R_factor_obs ? _refine_ls_shell.R_factor_R_free 0.2583 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.R_factor_R_work 0.2589 _refine_ls_shell.redundancy_reflns_all ? _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.wR_factor_all ? _refine_ls_shell.wR_factor_obs ? _refine_ls_shell.wR_factor_R_free ? _refine_ls_shell.wR_factor_R_work ? _refine_ls_shell.pdbx_total_number_of_bins_used 18 _refine_ls_shell.pdbx_phase_error ? _refine_ls_shell.pdbx_fsc_work ? _refine_ls_shell.pdbx_fsc_free ? # _struct.entry_id 4XX4 _struct.title 'Renin in complex with (4S)-4-isopropyl-4-methyl-6-oxo-1-(3-(2-oxo-4-phenylpyrrolidin-1-yl)benzyl)tetrahydropyrimidin-2(1H)-iminium' _struct.pdbx_descriptor Renin _struct.pdbx_model_details ? _struct.pdbx_formula_weight ? _struct.pdbx_formula_weight_method ? _struct.pdbx_model_type_details ? _struct.pdbx_CASP_flag ? # _struct_keywords.entry_id 4XX4 _struct_keywords.text ;Animals, Antihypertensive Agents, Blood Pressure, Drug Design, Enzyme Inhibitors, Models, Molecular, Protein Conformation, Renin, Structure-Activity Relationship, Hydrolase-Hydrolase Inhibitor complex ; _struct_keywords.pdbx_keywords 'Hydrolase/Hydrolase Inhibitor' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 1 ? C N N 2 ? D N N 3 ? E N N 3 ? F N N 4 ? G N N 4 ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 AA1 TYR A 55 ? TYR A 60 ? TYR A 121 TYR A 126 1 ? 6 HELX_P HELX_P2 AA2 ASP A 65 ? SER A 69 ? ASP A 131 SER A 135 5 ? 5 HELX_P HELX_P3 AA3 PRO A 115 ? MET A 120 ? PRO A 181 MET A 186 1 ? 6 HELX_P HELX_P4 AA4 PHE A 132 ? VAL A 140 ? PHE A 198 VAL A 206 5 ? 9 HELX_P HELX_P5 AA5 PRO A 142 ? GLN A 150 ? PRO A 208 GLN A 216 1 ? 9 HELX_P HELX_P6 AA6 ASP A 182 ? GLN A 184 ? ASP A 248 GLN A 250 5 ? 3 HELX_P HELX_P7 AA7 SER A 235 ? GLY A 247 ? SER A 301 GLY A 313 1 ? 13 HELX_P HELX_P8 AA8 ASN A 260 ? LEU A 265 ? ASN A 326 LEU A 331 5 ? 6 HELX_P HELX_P9 AA9 THR A 280 ? VAL A 285 ? THR A 346 VAL A 351 1 ? 6 HELX_P HELX_P10 AB1 GLY A 316 ? LYS A 322 ? GLY A 382 LYS A 388 1 ? 7 HELX_P HELX_P11 AB2 TYR B 55 ? TYR B 60 ? TYR B 121 TYR B 126 1 ? 6 HELX_P HELX_P12 AB3 ASP B 65 ? SER B 69 ? ASP B 131 SER B 135 5 ? 5 HELX_P HELX_P13 AB4 PRO B 115 ? MET B 120 ? PRO B 181 MET B 186 1 ? 6 HELX_P HELX_P14 AB5 PHE B 132 ? VAL B 140 ? PHE B 198 VAL B 206 5 ? 9 HELX_P HELX_P15 AB6 PRO B 142 ? GLN B 150 ? PRO B 208 GLN B 216 1 ? 9 HELX_P HELX_P16 AB7 ASP B 182 ? GLN B 184 ? ASP B 248 GLN B 250 5 ? 3 HELX_P HELX_P17 AB8 SER B 235 ? GLY B 247 ? SER B 301 GLY B 313 1 ? 13 HELX_P HELX_P18 AB9 ASN B 260 ? LEU B 265 ? ASN B 326 LEU B 331 5 ? 6 HELX_P HELX_P19 AC1 THR B 280 ? VAL B 285 ? THR B 346 VAL B 351 1 ? 6 HELX_P HELX_P20 AC2 GLY B 316 ? LYS B 322 ? GLY B 382 LYS B 388 1 ? 7 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 51 SG ? ? ? 1_555 A CYS 58 SG ? ? A CYS 117 A CYS 124 1_555 ? ? ? ? ? ? ? 2.017 ? disulf2 disulf ? ? A CYS 217 SG ? ? ? 1_555 A CYS 221 SG ? ? A CYS 283 A CYS 287 1_555 ? ? ? ? ? ? ? 2.038 ? disulf3 disulf ? ? A CYS 259 SG ? ? ? 1_555 A CYS 296 SG ? ? A CYS 325 A CYS 362 1_555 ? ? ? ? ? ? ? 2.028 ? disulf4 disulf ? ? B CYS 51 SG ? ? ? 1_555 B CYS 58 SG ? ? B CYS 117 B CYS 124 1_555 ? ? ? ? ? ? ? 2.023 ? disulf5 disulf ? ? B CYS 217 SG ? ? ? 1_555 B CYS 221 SG ? ? B CYS 283 B CYS 287 1_555 ? ? ? ? ? ? ? 2.027 ? disulf6 disulf ? ? B CYS 259 SG ? ? ? 1_555 B CYS 296 SG ? ? B CYS 325 B CYS 362 1_555 ? ? ? ? ? ? ? 2.036 ? covale1 covale one ? A ASN 75 ND2 ? ? ? 1_555 C NAG . C1 ? ? A ASN 141 A NAG 501 1_555 ? ? ? ? ? ? ? 1.432 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 THR 28 A . ? THR 94 A PRO 29 A ? PRO 95 A 1 -3.26 2 LEU 117 A . ? LEU 183 A PRO 118 A ? PRO 184 A 1 11.68 3 PRO 307 A . ? PRO 373 A PRO 308 A ? PRO 374 A 1 3.90 4 GLY 310 A . ? GLY 376 A PRO 311 A ? PRO 377 A 1 -2.10 5 THR 28 B . ? THR 94 B PRO 29 B ? PRO 95 B 1 -3.03 6 LEU 117 B . ? LEU 183 B PRO 118 B ? PRO 184 B 1 10.74 7 PRO 307 B . ? PRO 373 B PRO 308 B ? PRO 374 B 1 3.47 8 GLY 310 B . ? GLY 376 B PRO 311 B ? PRO 377 B 1 -2.54 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details AA1 ? 9 ? AA2 ? 13 ? AA3 ? 5 ? AA4 ? 4 ? AA5 ? 3 ? AA6 ? 9 ? AA7 ? 13 ? AA8 ? 5 ? AA9 ? 4 ? AB1 ? 3 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense AA1 1 2 ? anti-parallel AA1 2 3 ? anti-parallel AA1 3 4 ? anti-parallel AA1 4 5 ? anti-parallel AA1 5 6 ? anti-parallel AA1 6 7 ? anti-parallel AA1 7 8 ? anti-parallel AA1 8 9 ? anti-parallel AA2 1 2 ? anti-parallel AA2 2 3 ? anti-parallel AA2 3 4 ? parallel AA2 4 5 ? anti-parallel AA2 5 6 ? parallel AA2 6 7 ? anti-parallel AA2 7 8 ? anti-parallel AA2 8 9 ? anti-parallel AA2 9 10 ? anti-parallel AA2 10 11 ? anti-parallel AA2 11 12 ? anti-parallel AA2 12 13 ? anti-parallel AA3 1 2 ? anti-parallel AA3 2 3 ? parallel AA3 3 4 ? anti-parallel AA3 4 5 ? parallel AA4 1 2 ? anti-parallel AA4 2 3 ? anti-parallel AA4 3 4 ? anti-parallel AA5 1 2 ? anti-parallel AA5 2 3 ? anti-parallel AA6 1 2 ? anti-parallel AA6 2 3 ? anti-parallel AA6 3 4 ? anti-parallel AA6 4 5 ? anti-parallel AA6 5 6 ? anti-parallel AA6 6 7 ? anti-parallel AA6 7 8 ? anti-parallel AA6 8 9 ? anti-parallel AA7 1 2 ? anti-parallel AA7 2 3 ? anti-parallel AA7 3 4 ? parallel AA7 4 5 ? anti-parallel AA7 5 6 ? parallel AA7 6 7 ? anti-parallel AA7 7 8 ? anti-parallel AA7 8 9 ? anti-parallel AA7 9 10 ? anti-parallel AA7 10 11 ? anti-parallel AA7 11 12 ? anti-parallel AA7 12 13 ? anti-parallel AA8 1 2 ? anti-parallel AA8 2 3 ? parallel AA8 3 4 ? anti-parallel AA8 4 5 ? parallel AA9 1 2 ? anti-parallel AA9 2 3 ? anti-parallel AA9 3 4 ? anti-parallel AB1 1 2 ? anti-parallel AB1 2 3 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id AA1 1 LYS A 73 ? ARG A 82 ? LYS A 139 ARG A 148 AA1 2 THR A 87 ? VAL A 99 ? THR A 153 VAL A 165 AA1 3 GLN A 19 ? ILE A 26 ? GLN A 85 ILE A 92 AA1 4 SER A 8 ? TYR A 15 ? SER A 74 TYR A 81 AA1 5 GLY A 174 ? LEU A 178 ? GLY A 240 LEU A 244 AA1 6 VAL A 157 ? TYR A 162 ? VAL A 223 TYR A 228 AA1 7 PHE A 323 ? ASP A 328 ? PHE A 389 ASP A 394 AA1 8 ARG A 333 ? ALA A 339 ? ARG A 399 ALA A 405 AA1 9 TYR A 186 ? ASN A 194 ? TYR A 252 ASN A 260 AA2 1 LYS A 73 ? ARG A 82 ? LYS A 139 ARG A 148 AA2 2 THR A 87 ? VAL A 99 ? THR A 153 VAL A 165 AA2 3 ILE A 102 ? GLU A 113 ? ILE A 168 GLU A 179 AA2 4 VAL A 44 ? PRO A 47 ? VAL A 110 PRO A 113 AA2 5 GLY A 126 ? GLY A 129 ? GLY A 192 GLY A 195 AA2 6 GLN A 31 ? ASP A 38 ? GLN A 97 ASP A 104 AA2 7 GLN A 19 ? ILE A 26 ? GLN A 85 ILE A 92 AA2 8 SER A 8 ? TYR A 15 ? SER A 74 TYR A 81 AA2 9 GLY A 174 ? LEU A 178 ? GLY A 240 LEU A 244 AA2 10 VAL A 157 ? TYR A 162 ? VAL A 223 TYR A 228 AA2 11 PHE A 323 ? ASP A 328 ? PHE A 389 ASP A 394 AA2 12 ARG A 333 ? ALA A 339 ? ARG A 399 ALA A 405 AA2 13 TYR A 186 ? ASN A 194 ? TYR A 252 ASN A 260 AA3 1 GLN A 202 ? MET A 205 ? GLN A 268 MET A 271 AA3 2 CYS A 221 ? VAL A 225 ? CYS A 287 VAL A 291 AA3 3 TRP A 313 ? LEU A 315 ? TRP A 379 LEU A 381 AA3 4 ILE A 232 ? GLY A 234 ? ILE A 298 GLY A 300 AA3 5 ILE A 300 ? ALA A 302 ? ILE A 366 ALA A 368 AA4 1 THR A 214 ? LEU A 216 ? THR A 280 LEU A 282 AA4 2 GLY A 207 ? VAL A 210 ? GLY A 273 VAL A 276 AA4 3 ILE A 268 ? LEU A 272 ? ILE A 334 LEU A 338 AA4 4 LYS A 275 ? LEU A 279 ? LYS A 341 LEU A 345 AA5 1 LYS A 249 ? LYS A 250 ? LYS A 315 LYS A 316 AA5 2 TYR A 255 ? LYS A 258 ? TYR A 321 LYS A 324 AA5 3 LEU A 295 ? THR A 297 ? LEU A 361 THR A 363 AA6 1 LYS B 73 ? ARG B 82 ? LYS B 139 ARG B 148 AA6 2 THR B 87 ? VAL B 99 ? THR B 153 VAL B 165 AA6 3 GLN B 19 ? ILE B 26 ? GLN B 85 ILE B 92 AA6 4 SER B 8 ? TYR B 15 ? SER B 74 TYR B 81 AA6 5 GLY B 174 ? LEU B 178 ? GLY B 240 LEU B 244 AA6 6 VAL B 157 ? TYR B 162 ? VAL B 223 TYR B 228 AA6 7 PHE B 323 ? ASP B 328 ? PHE B 389 ASP B 394 AA6 8 ARG B 333 ? ALA B 339 ? ARG B 399 ALA B 405 AA6 9 TYR B 186 ? ASN B 194 ? TYR B 252 ASN B 260 AA7 1 LYS B 73 ? ARG B 82 ? LYS B 139 ARG B 148 AA7 2 THR B 87 ? VAL B 99 ? THR B 153 VAL B 165 AA7 3 ILE B 102 ? GLU B 113 ? ILE B 168 GLU B 179 AA7 4 VAL B 44 ? PRO B 47 ? VAL B 110 PRO B 113 AA7 5 GLY B 126 ? GLY B 129 ? GLY B 192 GLY B 195 AA7 6 GLN B 31 ? ASP B 38 ? GLN B 97 ASP B 104 AA7 7 GLN B 19 ? ILE B 26 ? GLN B 85 ILE B 92 AA7 8 SER B 8 ? TYR B 15 ? SER B 74 TYR B 81 AA7 9 GLY B 174 ? LEU B 178 ? GLY B 240 LEU B 244 AA7 10 VAL B 157 ? TYR B 162 ? VAL B 223 TYR B 228 AA7 11 PHE B 323 ? ASP B 328 ? PHE B 389 ASP B 394 AA7 12 ARG B 333 ? ALA B 339 ? ARG B 399 ALA B 405 AA7 13 TYR B 186 ? ASN B 194 ? TYR B 252 ASN B 260 AA8 1 GLN B 202 ? MET B 205 ? GLN B 268 MET B 271 AA8 2 CYS B 221 ? VAL B 225 ? CYS B 287 VAL B 291 AA8 3 TRP B 313 ? LEU B 315 ? TRP B 379 LEU B 381 AA8 4 ILE B 232 ? GLY B 234 ? ILE B 298 GLY B 300 AA8 5 ILE B 300 ? ALA B 302 ? ILE B 366 ALA B 368 AA9 1 LEU B 215 ? LEU B 216 ? LEU B 281 LEU B 282 AA9 2 GLY B 207 ? VAL B 210 ? GLY B 273 VAL B 276 AA9 3 ILE B 268 ? LEU B 272 ? ILE B 334 LEU B 338 AA9 4 LYS B 275 ? LEU B 279 ? LYS B 341 LEU B 345 AB1 1 LYS B 249 ? LYS B 250 ? LYS B 315 LYS B 316 AB1 2 TYR B 255 ? LYS B 258 ? TYR B 321 LYS B 324 AB1 3 LEU B 295 ? THR B 297 ? LEU B 361 THR B 363 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id AA1 1 2 N LEU A 81 ? N LEU A 147 O VAL A 88 ? O VAL A 154 AA1 2 3 O THR A 98 ? O THR A 164 N GLY A 25 ? N GLY A 91 AA1 3 4 O GLN A 19 ? O GLN A 85 N TYR A 15 ? N TYR A 81 AA1 4 5 N SER A 8 ? N SER A 74 O LEU A 178 ? O LEU A 244 AA1 5 6 O VAL A 177 ? O VAL A 243 N SER A 159 ? N SER A 225 AA1 6 7 N PHE A 158 ? N PHE A 224 O PHE A 327 ? O PHE A 393 AA1 7 8 N GLU A 326 ? N GLU A 392 O GLY A 335 ? O GLY A 401 AA1 8 9 O ILE A 334 ? O ILE A 400 N ILE A 193 ? N ILE A 259 AA2 1 2 N LEU A 81 ? N LEU A 147 O VAL A 88 ? O VAL A 154 AA2 2 3 N PHE A 91 ? N PHE A 157 O GLU A 110 ? O GLU A 176 AA2 3 4 O GLY A 109 ? O GLY A 175 N VAL A 44 ? N VAL A 110 AA2 4 5 N TRP A 45 ? N TRP A 111 O VAL A 127 ? O VAL A 193 AA2 5 6 O VAL A 128 ? O VAL A 194 N VAL A 36 ? N VAL A 102 AA2 6 7 O VAL A 35 ? O VAL A 101 N GLY A 22 ? N GLY A 88 AA2 7 8 O GLN A 19 ? O GLN A 85 N TYR A 15 ? N TYR A 81 AA2 8 9 N SER A 8 ? N SER A 74 O LEU A 178 ? O LEU A 244 AA2 9 10 O VAL A 177 ? O VAL A 243 N SER A 159 ? N SER A 225 AA2 10 11 N PHE A 158 ? N PHE A 224 O PHE A 327 ? O PHE A 393 AA2 11 12 N GLU A 326 ? N GLU A 392 O GLY A 335 ? O GLY A 401 AA2 12 13 O ILE A 334 ? O ILE A 400 N ILE A 193 ? N ILE A 259 AA3 1 2 N MET A 205 ? N MET A 271 O CYS A 221 ? O CYS A 287 AA3 2 3 N LEU A 224 ? N LEU A 290 O LEU A 315 ? O LEU A 381 AA3 3 4 O ALA A 314 ? O ALA A 380 N SER A 233 ? N SER A 299 AA3 4 5 N ILE A 232 ? N ILE A 298 O HIS A 301 ? O HIS A 367 AA4 1 2 O LEU A 216 ? O LEU A 282 N VAL A 208 ? N VAL A 274 AA4 2 3 N GLY A 207 ? N GLY A 273 O HIS A 271 ? O HIS A 337 AA4 3 4 N ILE A 268 ? N ILE A 334 O LEU A 279 ? O LEU A 345 AA5 1 2 N LYS A 249 ? N LYS A 315 O VAL A 256 ? O VAL A 322 AA5 2 3 N VAL A 257 ? N VAL A 323 O CYS A 296 ? O CYS A 362 AA6 1 2 N LEU B 81 ? N LEU B 147 O VAL B 88 ? O VAL B 154 AA6 2 3 O THR B 98 ? O THR B 164 N GLY B 25 ? N GLY B 91 AA6 3 4 O GLN B 19 ? O GLN B 85 N TYR B 15 ? N TYR B 81 AA6 4 5 N SER B 8 ? N SER B 74 O LEU B 178 ? O LEU B 244 AA6 5 6 O VAL B 177 ? O VAL B 243 N SER B 159 ? N SER B 225 AA6 6 7 N PHE B 158 ? N PHE B 224 O PHE B 327 ? O PHE B 393 AA6 7 8 N GLU B 326 ? N GLU B 392 O GLY B 335 ? O GLY B 401 AA6 8 9 O ILE B 334 ? O ILE B 400 N ILE B 193 ? N ILE B 259 AA7 1 2 N LEU B 81 ? N LEU B 147 O VAL B 88 ? O VAL B 154 AA7 2 3 N PHE B 91 ? N PHE B 157 O GLU B 110 ? O GLU B 176 AA7 3 4 O GLY B 109 ? O GLY B 175 N VAL B 44 ? N VAL B 110 AA7 4 5 N TRP B 45 ? N TRP B 111 O VAL B 127 ? O VAL B 193 AA7 5 6 O VAL B 128 ? O VAL B 194 N VAL B 36 ? N VAL B 102 AA7 6 7 O VAL B 35 ? O VAL B 101 N GLY B 22 ? N GLY B 88 AA7 7 8 O GLN B 19 ? O GLN B 85 N TYR B 15 ? N TYR B 81 AA7 8 9 N SER B 8 ? N SER B 74 O LEU B 178 ? O LEU B 244 AA7 9 10 O VAL B 177 ? O VAL B 243 N SER B 159 ? N SER B 225 AA7 10 11 N PHE B 158 ? N PHE B 224 O PHE B 327 ? O PHE B 393 AA7 11 12 N GLU B 326 ? N GLU B 392 O GLY B 335 ? O GLY B 401 AA7 12 13 O ILE B 334 ? O ILE B 400 N ILE B 193 ? N ILE B 259 AA8 1 2 N ILE B 203 ? N ILE B 269 O ALA B 223 ? O ALA B 289 AA8 2 3 N LEU B 224 ? N LEU B 290 O LEU B 315 ? O LEU B 381 AA8 3 4 O ALA B 314 ? O ALA B 380 N SER B 233 ? N SER B 299 AA8 4 5 N ILE B 232 ? N ILE B 298 O HIS B 301 ? O HIS B 367 AA9 1 2 O LEU B 216 ? O LEU B 282 N VAL B 208 ? N VAL B 274 AA9 2 3 N GLY B 207 ? N GLY B 273 O HIS B 271 ? O HIS B 337 AA9 3 4 N ILE B 268 ? N ILE B 334 O LEU B 279 ? O LEU B 345 AB1 1 2 N LYS B 249 ? N LYS B 315 O VAL B 256 ? O VAL B 322 AB1 2 3 N VAL B 257 ? N VAL B 323 O CYS B 296 ? O CYS B 362 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software A 70Y 502 ? 10 'binding site for residue 70Y A 502' AC2 Software B 70Y 501 ? 10 'binding site for residue 70Y B 501' AC3 Software A NAG 501 ? 2 'binding site for Mono-Saccharide NAG A 501 bound to ASN A 141' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 10 GLN A 19 ? GLN A 85 . ? 1_555 ? 2 AC1 10 ASP A 38 ? ASP A 104 . ? 1_555 ? 3 AC1 10 TYR A 83 ? TYR A 149 . ? 1_555 ? 4 AC1 10 SER A 84 ? SER A 150 . ? 1_555 ? 5 AC1 10 THR A 85 ? THR A 151 . ? 1_555 ? 6 AC1 10 PRO A 118 ? PRO A 184 . ? 1_555 ? 7 AC1 10 ASP A 226 ? ASP A 292 . ? 1_555 ? 8 AC1 10 GLY A 228 ? GLY A 294 . ? 1_555 ? 9 AC1 10 ALA A 229 ? ALA A 295 . ? 1_555 ? 10 AC1 10 SER A 230 ? SER A 296 . ? 1_555 ? 11 AC2 10 ASP B 38 ? ASP B 104 . ? 1_555 ? 12 AC2 10 TYR B 83 ? TYR B 149 . ? 1_555 ? 13 AC2 10 SER B 84 ? SER B 150 . ? 1_555 ? 14 AC2 10 THR B 85 ? THR B 151 . ? 1_555 ? 15 AC2 10 PRO B 118 ? PRO B 184 . ? 1_555 ? 16 AC2 10 ASP B 226 ? ASP B 292 . ? 1_555 ? 17 AC2 10 GLY B 228 ? GLY B 294 . ? 1_555 ? 18 AC2 10 ALA B 229 ? ALA B 295 . ? 1_555 ? 19 AC2 10 SER B 230 ? SER B 296 . ? 1_555 ? 20 AC2 10 MET B 303 ? MET B 369 . ? 1_555 ? 21 AC3 2 ASN A 75 ? ASN A 141 . ? 1_555 ? 22 AC3 2 HOH F . ? HOH A 605 . ? 1_555 ? # _atom_sites.entry_id 4XX4 _atom_sites.fract_transf_matrix[1][1] 0.007022 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.007022 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.007022 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . THR A 1 2 ? 5.818 70.596 45.283 1.00 92.09 ? 68 THR A N 1 ATOM 2 C CA . THR A 1 2 ? 5.124 70.868 46.540 1.00 91.70 ? 68 THR A CA 1 ATOM 3 C C . THR A 1 2 ? 6.154 71.139 47.640 1.00 94.25 ? 68 THR A C 1 ATOM 4 O O . THR A 1 2 ? 7.162 70.431 47.734 1.00 94.68 ? 68 THR A O 1 ATOM 5 C CB . THR A 1 2 ? 4.165 69.712 46.908 1.00 102.36 ? 68 THR A CB 1 ATOM 6 O OG1 . THR A 1 2 ? 3.479 69.258 45.736 1.00 105.07 ? 68 THR A OG1 1 ATOM 7 C CG2 . THR A 1 2 ? 3.148 70.105 47.983 1.00 100.08 ? 68 THR A CG2 1 ATOM 8 N N . LEU A 1 3 ? 5.911 72.178 48.456 1.00 88.36 ? 69 LEU A N 1 ATOM 9 C CA . LEU A 1 3 ? 6.810 72.542 49.550 1.00 86.80 ? 69 LEU A CA 1 ATOM 10 C C . LEU A 1 3 ? 6.122 72.438 50.921 1.00 87.42 ? 69 LEU A C 1 ATOM 11 O O . LEU A 1 3 ? 4.955 72.827 51.071 1.00 87.55 ? 69 LEU A O 1 ATOM 12 C CB . LEU A 1 3 ? 7.456 73.938 49.334 1.00 86.65 ? 69 LEU A CB 1 ATOM 13 C CG . LEU A 1 3 ? 8.460 74.097 48.153 1.00 90.84 ? 69 LEU A CG 1 ATOM 14 C CD1 . LEU A 1 3 ? 8.830 75.548 47.943 1.00 90.92 ? 69 LEU A CD1 1 ATOM 15 C CD2 . LEU A 1 3 ? 9.739 73.278 48.359 1.00 92.06 ? 69 LEU A CD2 1 ATOM 16 N N . GLY A 1 4 ? 6.851 71.879 51.886 1.00 79.53 ? 70 GLY A N 1 ATOM 17 C CA . GLY A 1 4 ? 6.396 71.710 53.258 1.00 77.09 ? 70 GLY A CA 1 ATOM 18 C C . GLY A 1 4 ? 7.081 72.709 54.161 1.00 76.11 ? 70 GLY A C 1 ATOM 19 O O . GLY A 1 4 ? 7.318 73.851 53.752 1.00 75.21 ? 70 GLY A O 1 ATOM 20 N N . ASN A 1 5 ? 7.433 72.274 55.383 1.00 69.95 ? 71 ASN A N 1 ATOM 21 C CA . ASN A 1 5 ? 8.121 73.118 56.366 1.00 69.10 ? 71 ASN A CA 1 ATOM 22 C C . ASN A 1 5 ? 9.181 72.324 57.160 1.00 70.98 ? 71 ASN A C 1 ATOM 23 O O . ASN A 1 5 ? 9.550 72.707 58.273 1.00 71.18 ? 71 ASN A O 1 ATOM 24 C CB . ASN A 1 5 ? 7.096 73.802 57.292 1.00 72.44 ? 71 ASN A CB 1 ATOM 25 C CG . ASN A 1 5 ? 7.449 75.223 57.684 1.00 104.03 ? 71 ASN A CG 1 ATOM 26 O OD1 . ASN A 1 5 ? 7.910 75.489 58.805 1.00 100.97 ? 71 ASN A OD1 1 ATOM 27 N ND2 . ASN A 1 5 ? 7.215 76.175 56.778 1.00 95.35 ? 71 ASN A ND2 1 ATOM 28 N N . THR A 1 6 ? 9.690 71.233 56.568 1.00 65.82 ? 72 THR A N 1 ATOM 29 C CA . THR A 1 6 ? 10.691 70.358 57.181 1.00 64.52 ? 72 THR A CA 1 ATOM 30 C C . THR A 1 6 ? 12.100 70.675 56.668 1.00 65.49 ? 72 THR A C 1 ATOM 31 O O . THR A 1 6 ? 12.321 70.884 55.476 1.00 64.04 ? 72 THR A O 1 ATOM 32 C CB . THR A 1 6 ? 10.272 68.860 57.015 1.00 72.60 ? 72 THR A CB 1 ATOM 33 O OG1 . THR A 1 6 ? 9.143 68.592 57.851 1.00 74.69 ? 72 THR A OG1 1 ATOM 34 C CG2 . THR A 1 6 ? 11.384 67.857 57.338 1.00 70.77 ? 72 THR A CG2 1 ATOM 35 N N . THR A 1 7 ? 13.036 70.721 57.607 1.00 61.03 ? 73 THR A N 1 ATOM 36 C CA . THR A 1 7 ? 14.467 70.841 57.397 1.00 59.96 ? 73 THR A CA 1 ATOM 37 C C . THR A 1 7 ? 15.006 69.592 58.090 1.00 62.44 ? 73 THR A C 1 ATOM 38 O O . THR A 1 7 ? 14.581 69.300 59.217 1.00 62.56 ? 73 THR A O 1 ATOM 39 C CB . THR A 1 7 ? 14.989 72.193 57.919 1.00 65.65 ? 73 THR A CB 1 ATOM 40 O OG1 . THR A 1 7 ? 15.576 72.905 56.831 1.00 68.09 ? 73 THR A OG1 1 ATOM 41 C CG2 . THR A 1 7 ? 16.000 72.068 59.060 1.00 63.21 ? 73 THR A CG2 1 ATOM 42 N N . SER A 1 8 ? 15.851 68.807 57.403 1.00 56.36 ? 74 SER A N 1 ATOM 43 C CA . SER A 1 8 ? 16.409 67.606 58.012 1.00 54.36 ? 74 SER A CA 1 ATOM 44 C C . SER A 1 8 ? 17.931 67.672 57.943 1.00 53.21 ? 74 SER A C 1 ATOM 45 O O . SER A 1 8 ? 18.484 67.927 56.881 1.00 52.79 ? 74 SER A O 1 ATOM 46 C CB . SER A 1 8 ? 15.842 66.346 57.363 1.00 58.80 ? 74 SER A CB 1 ATOM 47 O OG . SER A 1 8 ? 16.600 65.211 57.737 1.00 71.32 ? 74 SER A OG 1 ATOM 48 N N . SER A 1 9 ? 18.601 67.492 59.083 1.00 47.21 ? 75 SER A N 1 ATOM 49 C CA . SER A 1 9 ? 20.049 67.538 59.137 1.00 45.60 ? 75 SER A CA 1 ATOM 50 C C . SER A 1 9 ? 20.675 66.137 59.345 1.00 47.49 ? 75 SER A C 1 ATOM 51 O O . SER A 1 9 ? 20.106 65.292 60.045 1.00 48.95 ? 75 SER A O 1 ATOM 52 C CB . SER A 1 9 ? 20.522 68.570 60.158 1.00 48.94 ? 75 SER A CB 1 ATOM 53 O OG . SER A 1 9 ? 20.826 68.010 61.423 1.00 64.10 ? 75 SER A OG 1 ATOM 54 N N . VAL A 1 10 ? 21.787 65.871 58.642 1.00 40.44 ? 76 VAL A N 1 ATOM 55 C CA . VAL A 1 10 ? 22.557 64.619 58.751 1.00 38.27 ? 76 VAL A CA 1 ATOM 56 C C . VAL A 1 10 ? 23.973 65.019 59.235 1.00 37.88 ? 76 VAL A C 1 ATOM 57 O O . VAL A 1 10 ? 24.623 65.841 58.591 1.00 35.74 ? 76 VAL A O 1 ATOM 58 C CB . VAL A 1 10 ? 22.616 63.787 57.427 1.00 42.07 ? 76 VAL A CB 1 ATOM 59 C CG1 . VAL A 1 10 ? 23.258 62.416 57.661 1.00 41.79 ? 76 VAL A CG1 1 ATOM 60 C CG2 . VAL A 1 10 ? 21.242 63.622 56.789 1.00 42.08 ? 76 VAL A CG2 1 ATOM 61 N N . ILE A 1 11 ? 24.412 64.479 60.380 1.00 34.46 ? 77 ILE A N 1 ATOM 62 C CA . ILE A 1 11 ? 25.738 64.726 60.959 1.00 34.94 ? 77 ILE A CA 1 ATOM 63 C C . ILE A 1 11 ? 26.760 63.875 60.181 1.00 35.20 ? 77 ILE A C 1 ATOM 64 O O . ILE A 1 11 ? 26.560 62.671 59.981 1.00 32.85 ? 77 ILE A O 1 ATOM 65 C CB . ILE A 1 11 ? 25.790 64.439 62.507 1.00 38.81 ? 77 ILE A CB 1 ATOM 66 C CG1 . ILE A 1 11 ? 24.830 65.340 63.349 1.00 40.78 ? 77 ILE A CG1 1 ATOM 67 C CG2 . ILE A 1 11 ? 27.214 64.503 63.067 1.00 38.43 ? 77 ILE A CG2 1 ATOM 68 C CD1 . ILE A 1 11 ? 24.756 66.899 62.996 1.00 58.50 ? 77 ILE A CD1 1 ATOM 69 N N . LEU A 1 12 ? 27.871 64.495 59.795 1.00 30.75 ? 78 LEU A N 1 ATOM 70 C CA . LEU A 1 12 ? 28.917 63.788 59.042 1.00 29.72 ? 78 LEU A CA 1 ATOM 71 C C . LEU A 1 12 ? 30.162 63.618 59.873 1.00 32.90 ? 78 LEU A C 1 ATOM 72 O O . LEU A 1 12 ? 30.442 64.441 60.744 1.00 33.56 ? 78 LEU A O 1 ATOM 73 C CB . LEU A 1 12 ? 29.269 64.538 57.733 1.00 28.99 ? 78 LEU A CB 1 ATOM 74 C CG . LEU A 1 12 ? 28.114 64.945 56.805 1.00 31.32 ? 78 LEU A CG 1 ATOM 75 C CD1 . LEU A 1 12 ? 28.648 65.754 55.631 1.00 32.14 ? 78 LEU A CD1 1 ATOM 76 C CD2 . LEU A 1 12 ? 27.343 63.728 56.293 1.00 28.64 ? 78 LEU A CD2 1 ATOM 77 N N . THR A 1 13 ? 30.902 62.553 59.606 1.00 29.41 ? 79 THR A N 1 ATOM 78 C CA . THR A 1 13 ? 32.181 62.225 60.235 1.00 28.47 ? 79 THR A CA 1 ATOM 79 C C . THR A 1 13 ? 33.237 62.648 59.221 1.00 32.68 ? 79 THR A C 1 ATOM 80 O O . THR A 1 13 ? 33.097 62.384 58.031 1.00 33.06 ? 79 THR A O 1 ATOM 81 C CB . THR A 1 13 ? 32.277 60.717 60.504 1.00 33.90 ? 79 THR A CB 1 ATOM 82 O OG1 . THR A 1 13 ? 31.248 60.355 61.413 1.00 34.63 ? 79 THR A OG1 1 ATOM 83 C CG2 . THR A 1 13 ? 33.673 60.272 61.052 1.00 32.64 ? 79 THR A CG2 1 ATOM 84 N N . ASN A 1 14 ? 34.259 63.313 59.693 1.00 29.66 ? 80 ASN A N 1 ATOM 85 C CA . ASN A 1 14 ? 35.382 63.721 58.896 1.00 29.95 ? 80 ASN A CA 1 ATOM 86 C C . ASN A 1 14 ? 36.527 62.714 59.100 1.00 34.75 ? 80 ASN A C 1 ATOM 87 O O . ASN A 1 14 ? 37.148 62.670 60.166 1.00 32.94 ? 80 ASN A O 1 ATOM 88 C CB . ASN A 1 14 ? 35.842 65.122 59.306 1.00 29.61 ? 80 ASN A CB 1 ATOM 89 C CG . ASN A 1 14 ? 37.097 65.584 58.614 1.00 40.21 ? 80 ASN A CG 1 ATOM 90 O OD1 . ASN A 1 14 ? 37.747 64.851 57.875 1.00 31.99 ? 80 ASN A OD1 1 ATOM 91 N ND2 . ASN A 1 14 ? 37.442 66.840 58.806 1.00 31.78 ? 80 ASN A ND2 1 ATOM 92 N N . TYR A 1 15 ? 36.826 61.947 58.052 1.00 32.10 ? 81 TYR A N 1 ATOM 93 C CA . TYR A 1 15 ? 37.945 61.033 58.042 1.00 31.69 ? 81 TYR A CA 1 ATOM 94 C C . TYR A 1 15 ? 39.145 61.682 57.324 1.00 37.50 ? 81 TYR A C 1 ATOM 95 O O . TYR A 1 15 ? 39.128 61.803 56.101 1.00 37.53 ? 81 TYR A O 1 ATOM 96 C CB . TYR A 1 15 ? 37.562 59.704 57.384 1.00 32.52 ? 81 TYR A CB 1 ATOM 97 C CG . TYR A 1 15 ? 38.730 58.745 57.284 1.00 34.59 ? 81 TYR A CG 1 ATOM 98 C CD1 . TYR A 1 15 ? 39.227 58.100 58.414 1.00 36.91 ? 81 TYR A CD1 1 ATOM 99 C CD2 . TYR A 1 15 ? 39.369 58.519 56.071 1.00 35.02 ? 81 TYR A CD2 1 ATOM 100 C CE1 . TYR A 1 15 ? 40.302 57.221 58.329 1.00 38.04 ? 81 TYR A CE1 1 ATOM 101 C CE2 . TYR A 1 15 ? 40.454 57.651 55.976 1.00 36.15 ? 81 TYR A CE2 1 ATOM 102 C CZ . TYR A 1 15 ? 40.915 57.002 57.107 1.00 45.25 ? 81 TYR A CZ 1 ATOM 103 O OH . TYR A 1 15 ? 41.988 56.153 57.011 1.00 48.66 ? 81 TYR A OH 1 ATOM 104 N N . MET A 1 16 ? 40.180 62.095 58.091 1.00 36.29 ? 82 MET A N 1 ATOM 105 C CA . MET A 1 16 ? 41.459 62.648 57.602 1.00 37.23 ? 82 MET A CA 1 ATOM 106 C C . MET A 1 16 ? 41.338 63.808 56.589 1.00 39.50 ? 82 MET A C 1 ATOM 107 O O . MET A 1 16 ? 42.222 63.942 55.750 1.00 39.44 ? 82 MET A O 1 ATOM 108 C CB . MET A 1 16 ? 42.274 61.518 56.928 1.00 40.56 ? 82 MET A CB 1 ATOM 109 C CG . MET A 1 16 ? 42.957 60.559 57.841 1.00 46.85 ? 82 MET A CG 1 ATOM 110 S SD . MET A 1 16 ? 43.661 59.143 56.900 1.00 54.20 ? 82 MET A SD 1 ATOM 111 C CE . MET A 1 16 ? 44.341 59.958 55.299 1.00 51.05 ? 82 MET A CE 1 ATOM 112 N N . ASP A 1 17 ? 40.251 64.605 56.616 1.00 35.53 ? 83 ASP A N 1 ATOM 113 C CA . ASP A 1 17 ? 40.007 65.703 55.649 1.00 34.54 ? 83 ASP A CA 1 ATOM 114 C C . ASP A 1 17 ? 39.806 65.208 54.208 1.00 34.74 ? 83 ASP A C 1 ATOM 115 O O . ASP A 1 17 ? 39.856 66.025 53.291 1.00 34.15 ? 83 ASP A O 1 ATOM 116 C CB . ASP A 1 17 ? 41.155 66.754 55.671 1.00 35.99 ? 83 ASP A CB 1 ATOM 117 C CG . ASP A 1 17 ? 41.026 67.857 56.701 1.00 41.06 ? 83 ASP A CG 1 ATOM 118 O OD1 . ASP A 1 17 ? 40.091 67.787 57.538 1.00 38.35 ? 83 ASP A OD1 1 ATOM 119 O OD2 . ASP A 1 17 ? 41.822 68.821 56.632 1.00 48.34 ? 83 ASP A OD2 1 ATOM 120 N N . THR A 1 18 ? 39.629 63.892 53.995 1.00 29.66 ? 84 THR A N 1 ATOM 121 C CA . THR A 1 18 ? 39.484 63.356 52.637 1.00 30.46 ? 84 THR A CA 1 ATOM 122 C C . THR A 1 18 ? 38.172 62.609 52.400 1.00 34.76 ? 84 THR A C 1 ATOM 123 O O . THR A 1 18 ? 37.791 62.409 51.249 1.00 34.20 ? 84 THR A O 1 ATOM 124 C CB . THR A 1 18 ? 40.704 62.466 52.230 1.00 38.77 ? 84 THR A CB 1 ATOM 125 O OG1 . THR A 1 18 ? 40.809 61.361 53.128 1.00 40.58 ? 84 THR A OG1 1 ATOM 126 C CG2 . THR A 1 18 ? 42.022 63.224 52.162 1.00 28.16 ? 84 THR A CG2 1 ATOM 127 N N . GLN A 1 19 ? 37.516 62.132 53.469 1.00 30.69 ? 85 GLN A N 1 ATOM 128 C CA . GLN A 1 19 ? 36.257 61.386 53.335 1.00 29.29 ? 85 GLN A CA 1 ATOM 129 C C . GLN A 1 19 ? 35.278 61.913 54.374 1.00 32.50 ? 85 GLN A C 1 ATOM 130 O O . GLN A 1 19 ? 35.604 61.979 55.555 1.00 31.68 ? 85 GLN A O 1 ATOM 131 C CB . GLN A 1 19 ? 36.482 59.870 53.512 1.00 30.68 ? 85 GLN A CB 1 ATOM 132 C CG . GLN A 1 19 ? 37.526 59.256 52.557 1.00 28.81 ? 85 GLN A CG 1 ATOM 133 C CD . GLN A 1 19 ? 37.823 57.808 52.836 1.00 41.71 ? 85 GLN A CD 1 ATOM 134 O OE1 . GLN A 1 19 ? 36.942 57.058 53.234 1.00 31.53 ? 85 GLN A OE1 1 ATOM 135 N NE2 . GLN A 1 19 ? 39.061 57.369 52.602 1.00 37.47 ? 85 GLN A NE2 1 ATOM 136 N N . TYR A 1 20 ? 34.109 62.372 53.911 1.00 29.32 ? 86 TYR A N 1 ATOM 137 C CA . TYR A 1 20 ? 33.043 62.900 54.759 1.00 28.56 ? 86 TYR A CA 1 ATOM 138 C C . TYR A 1 20 ? 31.822 62.029 54.522 1.00 33.46 ? 86 TYR A C 1 ATOM 139 O O . TYR A 1 20 ? 31.370 61.892 53.388 1.00 31.93 ? 86 TYR A O 1 ATOM 140 C CB . TYR A 1 20 ? 32.745 64.366 54.444 1.00 28.05 ? 86 TYR A CB 1 ATOM 141 C CG . TYR A 1 20 ? 33.867 65.322 54.796 1.00 28.65 ? 86 TYR A CG 1 ATOM 142 C CD1 . TYR A 1 20 ? 34.947 65.504 53.938 1.00 28.44 ? 86 TYR A CD1 1 ATOM 143 C CD2 . TYR A 1 20 ? 33.815 66.099 55.956 1.00 28.97 ? 86 TYR A CD2 1 ATOM 144 C CE1 . TYR A 1 20 ? 35.978 66.387 54.254 1.00 26.40 ? 86 TYR A CE1 1 ATOM 145 C CE2 . TYR A 1 20 ? 34.824 67.009 56.262 1.00 28.92 ? 86 TYR A CE2 1 ATOM 146 C CZ . TYR A 1 20 ? 35.906 67.145 55.409 1.00 30.11 ? 86 TYR A CZ 1 ATOM 147 O OH . TYR A 1 20 ? 36.908 68.028 55.711 1.00 26.05 ? 86 TYR A OH 1 ATOM 148 N N . TYR A 1 21 ? 31.348 61.376 55.584 1.00 31.17 ? 87 TYR A N 1 ATOM 149 C CA . TYR A 1 21 ? 30.250 60.428 55.478 1.00 30.58 ? 87 TYR A CA 1 ATOM 150 C C . TYR A 1 21 ? 29.296 60.532 56.637 1.00 32.65 ? 87 TYR A C 1 ATOM 151 O O . TYR A 1 21 ? 29.679 60.920 57.733 1.00 30.74 ? 87 TYR A O 1 ATOM 152 C CB . TYR A 1 21 ? 30.781 58.977 55.320 1.00 32.18 ? 87 TYR A CB 1 ATOM 153 C CG . TYR A 1 21 ? 31.785 58.562 56.363 1.00 35.53 ? 87 TYR A CG 1 ATOM 154 C CD1 . TYR A 1 21 ? 31.377 57.988 57.573 1.00 37.50 ? 87 TYR A CD1 1 ATOM 155 C CD2 . TYR A 1 21 ? 33.142 58.738 56.151 1.00 36.94 ? 87 TYR A CD2 1 ATOM 156 C CE1 . TYR A 1 21 ? 32.306 57.617 58.551 1.00 38.15 ? 87 TYR A CE1 1 ATOM 157 C CE2 . TYR A 1 21 ? 34.072 58.394 57.122 1.00 38.19 ? 87 TYR A CE2 1 ATOM 158 C CZ . TYR A 1 21 ? 33.655 57.829 58.321 1.00 48.65 ? 87 TYR A CZ 1 ATOM 159 O OH . TYR A 1 21 ? 34.594 57.475 59.269 1.00 59.27 ? 87 TYR A OH 1 ATOM 160 N N . GLY A 1 22 ? 28.063 60.154 56.380 1.00 30.85 ? 88 GLY A N 1 ATOM 161 C CA . GLY A 1 22 ? 27.005 60.110 57.376 1.00 30.65 ? 88 GLY A CA 1 ATOM 162 C C . GLY A 1 22 ? 26.313 58.762 57.272 1.00 34.45 ? 88 GLY A C 1 ATOM 163 O O . GLY A 1 22 ? 26.665 57.931 56.428 1.00 34.65 ? 88 GLY A O 1 ATOM 164 N N . GLU A 1 23 ? 25.328 58.549 58.122 1.00 31.85 ? 89 GLU A N 1 ATOM 165 C CA . GLU A 1 23 ? 24.575 57.304 58.214 1.00 31.64 ? 89 GLU A CA 1 ATOM 166 C C . GLU A 1 23 ? 23.232 57.361 57.501 1.00 34.65 ? 89 GLU A C 1 ATOM 167 O O . GLU A 1 23 ? 22.558 58.398 57.469 1.00 33.16 ? 89 GLU A O 1 ATOM 168 C CB . GLU A 1 23 ? 24.374 56.925 59.700 1.00 33.04 ? 89 GLU A CB 1 ATOM 169 C CG . GLU A 1 23 ? 24.104 55.443 59.924 1.00 46.96 ? 89 GLU A CG 1 ATOM 170 C CD . GLU A 1 23 ? 23.789 55.012 61.343 1.00 63.76 ? 89 GLU A CD 1 ATOM 171 O OE1 . GLU A 1 23 ? 24.696 54.460 62.008 1.00 62.63 ? 89 GLU A OE1 1 ATOM 172 O OE2 . GLU A 1 23 ? 22.628 55.189 61.779 1.00 53.45 ? 89 GLU A OE2 1 ATOM 173 N N . ILE A 1 24 ? 22.875 56.235 56.900 1.00 31.27 ? 90 ILE A N 1 ATOM 174 C CA . ILE A 1 24 ? 21.578 55.946 56.286 1.00 30.96 ? 90 ILE A CA 1 ATOM 175 C C . ILE A 1 24 ? 21.204 54.534 56.781 1.00 34.30 ? 90 ILE A C 1 ATOM 176 O O . ILE A 1 24 ? 22.101 53.761 57.136 1.00 33.61 ? 90 ILE A O 1 ATOM 177 C CB . ILE A 1 24 ? 21.531 56.054 54.729 1.00 33.68 ? 90 ILE A CB 1 ATOM 178 C CG1 . ILE A 1 24 ? 22.538 55.084 54.045 1.00 33.29 ? 90 ILE A CG1 1 ATOM 179 C CG2 . ILE A 1 24 ? 21.697 57.496 54.257 1.00 34.28 ? 90 ILE A CG2 1 ATOM 180 C CD1 . ILE A 1 24 ? 22.100 54.526 52.693 1.00 28.05 ? 90 ILE A CD1 1 ATOM 181 N N . GLY A 1 25 ? 19.903 54.250 56.848 1.00 29.68 ? 91 GLY A N 1 ATOM 182 C CA . GLY A 1 25 ? 19.356 52.956 57.228 1.00 28.21 ? 91 GLY A CA 1 ATOM 183 C C . GLY A 1 25 ? 18.583 52.402 56.056 1.00 31.07 ? 91 GLY A C 1 ATOM 184 O O . GLY A 1 25 ? 17.752 53.115 55.492 1.00 30.88 ? 91 GLY A O 1 ATOM 185 N N . ILE A 1 26 ? 18.875 51.150 55.645 1.00 27.55 ? 92 ILE A N 1 ATOM 186 C CA . ILE A 1 26 ? 18.179 50.482 54.529 1.00 27.31 ? 92 ILE A CA 1 ATOM 187 C C . ILE A 1 26 ? 17.471 49.207 55.022 1.00 32.04 ? 92 ILE A C 1 ATOM 188 O O . ILE A 1 26 ? 18.099 48.364 55.657 1.00 30.81 ? 92 ILE A O 1 ATOM 189 C CB . ILE A 1 26 ? 19.086 50.173 53.285 1.00 29.26 ? 92 ILE A CB 1 ATOM 190 C CG1 . ILE A 1 26 ? 20.038 51.353 52.928 1.00 28.53 ? 92 ILE A CG1 1 ATOM 191 C CG2 . ILE A 1 26 ? 18.244 49.721 52.071 1.00 27.48 ? 92 ILE A CG2 1 ATOM 192 C CD1 . ILE A 1 26 ? 20.990 51.049 51.805 1.00 31.96 ? 92 ILE A CD1 1 ATOM 193 N N . GLY A 1 27 ? 16.186 49.080 54.685 1.00 29.01 ? 93 GLY A N 1 ATOM 194 C CA . GLY A 1 27 ? 15.396 47.907 55.026 1.00 29.31 ? 93 GLY A CA 1 ATOM 195 C C . GLY A 1 27 ? 14.586 47.969 56.308 1.00 35.52 ? 93 GLY A C 1 ATOM 196 O O . GLY A 1 27 ? 14.558 49.002 56.995 1.00 34.88 ? 93 GLY A O 1 ATOM 197 N N . THR A 1 28 ? 13.870 46.850 56.584 1.00 32.38 ? 94 THR A N 1 ATOM 198 C CA . THR A 1 28 ? 13.030 46.605 57.762 1.00 31.68 ? 94 THR A CA 1 ATOM 199 C C . THR A 1 28 ? 13.429 45.242 58.368 1.00 34.23 ? 94 THR A C 1 ATOM 200 O O . THR A 1 28 ? 13.138 44.215 57.753 1.00 34.41 ? 94 THR A O 1 ATOM 201 C CB . THR A 1 28 ? 11.524 46.694 57.421 1.00 39.21 ? 94 THR A CB 1 ATOM 202 O OG1 . THR A 1 28 ? 11.267 47.911 56.693 1.00 39.25 ? 94 THR A OG1 1 ATOM 203 C CG2 . THR A 1 28 ? 10.650 46.651 58.675 1.00 32.74 ? 94 THR A CG2 1 ATOM 204 N N . PRO A 1 29 ? 14.109 45.188 59.543 1.00 29.57 ? 95 PRO A N 1 ATOM 205 C CA . PRO A 1 29 ? 14.609 46.326 60.347 1.00 30.07 ? 95 PRO A CA 1 ATOM 206 C C . PRO A 1 29 ? 15.750 47.047 59.588 1.00 36.94 ? 95 PRO A C 1 ATOM 207 O O . PRO A 1 29 ? 16.327 46.451 58.661 1.00 34.41 ? 95 PRO A O 1 ATOM 208 C CB . PRO A 1 29 ? 15.105 45.647 61.638 1.00 31.16 ? 95 PRO A CB 1 ATOM 209 C CG . PRO A 1 29 ? 15.489 44.258 61.224 1.00 34.50 ? 95 PRO A CG 1 ATOM 210 C CD . PRO A 1 29 ? 14.527 43.887 60.116 1.00 30.07 ? 95 PRO A CD 1 ATOM 211 N N . PRO A 1 30 ? 16.090 48.317 59.904 1.00 34.23 ? 96 PRO A N 1 ATOM 212 C CA . PRO A 1 30 ? 17.145 48.983 59.115 1.00 32.86 ? 96 PRO A CA 1 ATOM 213 C C . PRO A 1 30 ? 18.536 48.392 59.306 1.00 34.66 ? 96 PRO A C 1 ATOM 214 O O . PRO A 1 30 ? 18.906 47.982 60.407 1.00 33.79 ? 96 PRO A O 1 ATOM 215 C CB . PRO A 1 30 ? 17.061 50.464 59.543 1.00 34.19 ? 96 PRO A CB 1 ATOM 216 C CG . PRO A 1 30 ? 16.380 50.441 60.861 1.00 38.38 ? 96 PRO A CG 1 ATOM 217 C CD . PRO A 1 30 ? 15.488 49.231 60.903 1.00 34.30 ? 96 PRO A CD 1 ATOM 218 N N . GLN A 1 31 ? 19.283 48.284 58.189 1.00 30.26 ? 97 GLN A N 1 ATOM 219 C CA . GLN A 1 31 ? 20.680 47.875 58.152 1.00 29.42 ? 97 GLN A CA 1 ATOM 220 C C . GLN A 1 31 ? 21.386 49.203 57.875 1.00 32.00 ? 97 GLN A C 1 ATOM 221 O O . GLN A 1 31 ? 20.952 49.936 56.986 1.00 29.57 ? 97 GLN A O 1 ATOM 222 C CB . GLN A 1 31 ? 20.933 46.853 57.037 1.00 30.75 ? 97 GLN A CB 1 ATOM 223 C CG . GLN A 1 31 ? 20.165 45.553 57.212 1.00 30.85 ? 97 GLN A CG 1 ATOM 224 C CD . GLN A 1 31 ? 20.231 44.674 55.996 1.00 37.40 ? 97 GLN A CD 1 ATOM 225 O OE1 . GLN A 1 31 ? 21.297 44.458 55.407 1.00 26.29 ? 97 GLN A OE1 1 ATOM 226 N NE2 . GLN A 1 31 ? 19.095 44.133 55.602 1.00 25.47 ? 97 GLN A NE2 1 ATOM 227 N N . THR A 1 32 ? 22.391 49.573 58.698 1.00 29.60 ? 98 THR A N 1 ATOM 228 C CA . THR A 1 32 ? 23.020 50.889 58.585 1.00 28.99 ? 98 THR A CA 1 ATOM 229 C C . THR A 1 32 ? 24.282 50.881 57.750 1.00 31.34 ? 98 THR A C 1 ATOM 230 O O . THR A 1 32 ? 25.051 49.933 57.785 1.00 31.11 ? 98 THR A O 1 ATOM 231 C CB . THR A 1 32 ? 23.242 51.546 59.955 1.00 31.59 ? 98 THR A CB 1 ATOM 232 O OG1 . THR A 1 32 ? 24.201 50.790 60.693 1.00 36.66 ? 98 THR A OG1 1 ATOM 233 C CG2 . THR A 1 32 ? 21.939 51.724 60.750 1.00 23.89 ? 98 THR A CG2 1 ATOM 234 N N . PHE A 1 33 ? 24.490 51.971 57.003 1.00 28.28 ? 99 PHE A N 1 ATOM 235 C CA . PHE A 1 33 ? 25.646 52.184 56.132 1.00 26.71 ? 99 PHE A CA 1 ATOM 236 C C . PHE A 1 33 ? 26.202 53.565 56.316 1.00 30.22 ? 99 PHE A C 1 ATOM 237 O O . PHE A 1 33 ? 25.463 54.497 56.606 1.00 29.62 ? 99 PHE A O 1 ATOM 238 C CB . PHE A 1 33 ? 25.299 51.962 54.634 1.00 26.75 ? 99 PHE A CB 1 ATOM 239 C CG . PHE A 1 33 ? 24.828 50.558 54.377 1.00 25.77 ? 99 PHE A CG 1 ATOM 240 C CD1 . PHE A 1 33 ? 23.487 50.220 54.527 1.00 28.44 ? 99 PHE A CD1 1 ATOM 241 C CD2 . PHE A 1 33 ? 25.726 49.558 54.032 1.00 23.13 ? 99 PHE A CD2 1 ATOM 242 C CE1 . PHE A 1 33 ? 23.068 48.895 54.385 1.00 27.49 ? 99 PHE A CE1 1 ATOM 243 C CE2 . PHE A 1 33 ? 25.303 48.258 53.863 1.00 24.81 ? 99 PHE A CE2 1 ATOM 244 C CZ . PHE A 1 33 ? 23.986 47.925 54.066 1.00 24.42 ? 99 PHE A CZ 1 ATOM 245 N N . LYS A 1 34 ? 27.530 53.669 56.174 1.00 27.94 ? 100 LYS A N 1 ATOM 246 C CA . LYS A 1 34 ? 28.307 54.908 56.179 1.00 26.81 ? 100 LYS A CA 1 ATOM 247 C C . LYS A 1 34 ? 28.373 55.301 54.702 1.00 28.58 ? 100 LYS A C 1 ATOM 248 O O . LYS A 1 34 ? 28.868 54.540 53.875 1.00 25.76 ? 100 LYS A O 1 ATOM 249 C CB . LYS A 1 34 ? 29.729 54.648 56.735 1.00 27.61 ? 100 LYS A CB 1 ATOM 250 C CG . LYS A 1 34 ? 29.754 54.315 58.211 1.00 28.04 ? 100 LYS A CG 1 ATOM 251 C CD . LYS A 1 34 ? 31.110 53.779 58.629 1.00 30.50 ? 100 LYS A CD 1 ATOM 252 C CE . LYS A 1 34 ? 31.073 53.222 60.027 1.00 49.26 ? 100 LYS A CE 1 ATOM 253 N NZ . LYS A 1 34 ? 32.345 52.543 60.376 1.00 69.87 ? 100 LYS A NZ 1 ATOM 254 N N . VAL A 1 35 ? 27.803 56.438 54.356 1.00 29.24 ? 101 VAL A N 1 ATOM 255 C CA . VAL A 1 35 ? 27.762 56.878 52.954 1.00 28.84 ? 101 VAL A CA 1 ATOM 256 C C . VAL A 1 35 ? 28.302 58.300 52.756 1.00 31.81 ? 101 VAL A C 1 ATOM 257 O O . VAL A 1 35 ? 28.123 59.157 53.629 1.00 29.84 ? 101 VAL A O 1 ATOM 258 C CB . VAL A 1 35 ? 26.343 56.715 52.325 1.00 31.05 ? 101 VAL A CB 1 ATOM 259 C CG1 . VAL A 1 35 ? 25.951 55.240 52.209 1.00 30.28 ? 101 VAL A CG1 1 ATOM 260 C CG2 . VAL A 1 35 ? 25.289 57.507 53.114 1.00 31.04 ? 101 VAL A CG2 1 ATOM 261 N N . VAL A 1 36 ? 28.934 58.542 51.588 1.00 28.38 ? 102 VAL A N 1 ATOM 262 C CA . VAL A 1 36 ? 29.382 59.866 51.142 1.00 27.62 ? 102 VAL A CA 1 ATOM 263 C C . VAL A 1 36 ? 28.176 60.458 50.382 1.00 30.83 ? 102 VAL A C 1 ATOM 264 O O . VAL A 1 36 ? 27.575 59.765 49.545 1.00 30.88 ? 102 VAL A O 1 ATOM 265 C CB . VAL A 1 36 ? 30.625 59.777 50.211 1.00 31.04 ? 102 VAL A CB 1 ATOM 266 C CG1 . VAL A 1 36 ? 30.988 61.142 49.611 1.00 29.82 ? 102 VAL A CG1 1 ATOM 267 C CG2 . VAL A 1 36 ? 31.811 59.186 50.951 1.00 30.96 ? 102 VAL A CG2 1 ATOM 268 N N . PHE A 1 37 ? 27.802 61.704 50.697 1.00 26.41 ? 103 PHE A N 1 ATOM 269 C CA . PHE A 1 37 ? 26.714 62.401 50.009 1.00 26.43 ? 103 PHE A CA 1 ATOM 270 C C . PHE A 1 37 ? 27.434 63.189 48.917 1.00 32.57 ? 103 PHE A C 1 ATOM 271 O O . PHE A 1 37 ? 28.206 64.116 49.185 1.00 31.63 ? 103 PHE A O 1 ATOM 272 C CB . PHE A 1 37 ? 25.893 63.257 50.991 1.00 27.87 ? 103 PHE A CB 1 ATOM 273 C CG . PHE A 1 37 ? 25.186 62.418 52.038 1.00 28.83 ? 103 PHE A CG 1 ATOM 274 C CD1 . PHE A 1 37 ? 23.949 61.844 51.776 1.00 32.26 ? 103 PHE A CD1 1 ATOM 275 C CD2 . PHE A 1 37 ? 25.765 62.194 53.283 1.00 29.02 ? 103 PHE A CD2 1 ATOM 276 C CE1 . PHE A 1 37 ? 23.303 61.057 52.745 1.00 33.31 ? 103 PHE A CE1 1 ATOM 277 C CE2 . PHE A 1 37 ? 25.103 61.445 54.258 1.00 31.15 ? 103 PHE A CE2 1 ATOM 278 C CZ . PHE A 1 37 ? 23.869 60.893 53.990 1.00 30.00 ? 103 PHE A CZ 1 ATOM 279 N N . ASP A 1 38 ? 27.275 62.713 47.690 1.00 30.41 ? 104 ASP A N 1 ATOM 280 C CA . ASP A 1 38 ? 28.071 63.127 46.546 1.00 30.03 ? 104 ASP A CA 1 ATOM 281 C C . ASP A 1 38 ? 27.333 63.874 45.420 1.00 34.42 ? 104 ASP A C 1 ATOM 282 O O . ASP A 1 38 ? 26.581 63.261 44.677 1.00 35.42 ? 104 ASP A O 1 ATOM 283 C CB . ASP A 1 38 ? 28.755 61.853 46.014 1.00 29.99 ? 104 ASP A CB 1 ATOM 284 C CG . ASP A 1 38 ? 29.611 61.983 44.794 1.00 36.18 ? 104 ASP A CG 1 ATOM 285 O OD1 . ASP A 1 38 ? 30.233 63.047 44.614 1.00 39.70 ? 104 ASP A OD1 1 ATOM 286 O OD2 . ASP A 1 38 ? 29.692 61.014 44.041 1.00 33.88 ? 104 ASP A OD2 1 ATOM 287 N N . THR A 1 39 ? 27.639 65.167 45.235 1.00 31.28 ? 105 THR A N 1 ATOM 288 C CA . THR A 1 39 ? 27.037 65.982 44.154 1.00 32.17 ? 105 THR A CA 1 ATOM 289 C C . THR A 1 39 ? 27.621 65.648 42.771 1.00 38.03 ? 105 THR A C 1 ATOM 290 O O . THR A 1 39 ? 26.995 65.956 41.754 1.00 39.03 ? 105 THR A O 1 ATOM 291 C CB . THR A 1 39 ? 27.095 67.474 44.451 1.00 36.49 ? 105 THR A CB 1 ATOM 292 O OG1 . THR A 1 39 ? 28.466 67.844 44.659 1.00 35.05 ? 105 THR A OG1 1 ATOM 293 C CG2 . THR A 1 39 ? 26.213 67.871 45.655 1.00 31.79 ? 105 THR A CG2 1 ATOM 294 N N . GLY A 1 40 ? 28.770 64.980 42.745 1.00 33.27 ? 106 GLY A N 1 ATOM 295 C CA . GLY A 1 40 ? 29.397 64.558 41.496 1.00 33.46 ? 106 GLY A CA 1 ATOM 296 C C . GLY A 1 40 ? 28.923 63.230 40.923 1.00 38.04 ? 106 GLY A C 1 ATOM 297 O O . GLY A 1 40 ? 29.553 62.712 40.004 1.00 39.00 ? 106 GLY A O 1 ATOM 298 N N . SER A 1 41 ? 27.842 62.639 41.475 1.00 33.51 ? 107 SER A N 1 ATOM 299 C CA . SER A 1 41 ? 27.229 61.381 41.012 1.00 32.34 ? 107 SER A CA 1 ATOM 300 C C . SER A 1 41 ? 25.739 61.381 41.381 1.00 33.87 ? 107 SER A C 1 ATOM 301 O O . SER A 1 41 ? 25.334 62.222 42.182 1.00 32.09 ? 107 SER A O 1 ATOM 302 C CB . SER A 1 41 ? 27.974 60.148 41.536 1.00 34.84 ? 107 SER A CB 1 ATOM 303 O OG . SER A 1 41 ? 27.652 59.817 42.878 1.00 38.10 ? 107 SER A OG 1 ATOM 304 N N . SER A 1 42 ? 24.923 60.486 40.775 1.00 30.09 ? 108 SER A N 1 ATOM 305 C CA . SER A 1 42 ? 23.469 60.490 40.973 1.00 30.01 ? 108 SER A CA 1 ATOM 306 C C . SER A 1 42 ? 22.848 59.159 41.429 1.00 34.57 ? 108 SER A C 1 ATOM 307 O O . SER A 1 42 ? 21.625 59.040 41.515 1.00 35.66 ? 108 SER A O 1 ATOM 308 C CB . SER A 1 42 ? 22.785 60.949 39.683 1.00 34.49 ? 108 SER A CB 1 ATOM 309 O OG . SER A 1 42 ? 23.402 62.074 39.073 1.00 46.81 ? 108 SER A OG 1 ATOM 310 N N . ASN A 1 43 ? 23.664 58.147 41.674 1.00 29.70 ? 109 ASN A N 1 ATOM 311 C CA . ASN A 1 43 ? 23.149 56.845 42.070 1.00 27.91 ? 109 ASN A CA 1 ATOM 312 C C . ASN A 1 43 ? 23.439 56.556 43.527 1.00 31.46 ? 109 ASN A C 1 ATOM 313 O O . ASN A 1 43 ? 24.426 57.042 44.074 1.00 32.34 ? 109 ASN A O 1 ATOM 314 C CB . ASN A 1 43 ? 23.748 55.732 41.185 1.00 23.58 ? 109 ASN A CB 1 ATOM 315 C CG . ASN A 1 43 ? 23.290 55.773 39.757 1.00 37.89 ? 109 ASN A CG 1 ATOM 316 O OD1 . ASN A 1 43 ? 23.725 56.614 38.967 1.00 36.78 ? 109 ASN A OD1 1 ATOM 317 N ND2 . ASN A 1 43 ? 22.420 54.846 39.386 1.00 29.62 ? 109 ASN A ND2 1 ATOM 318 N N . VAL A 1 44 ? 22.567 55.770 44.153 1.00 27.13 ? 110 VAL A N 1 ATOM 319 C CA . VAL A 1 44 ? 22.740 55.300 45.519 1.00 26.47 ? 110 VAL A CA 1 ATOM 320 C C . VAL A 1 44 ? 23.239 53.862 45.348 1.00 31.39 ? 110 VAL A C 1 ATOM 321 O O . VAL A 1 44 ? 22.716 53.112 44.518 1.00 31.29 ? 110 VAL A O 1 ATOM 322 C CB . VAL A 1 44 ? 21.417 55.350 46.349 1.00 29.58 ? 110 VAL A CB 1 ATOM 323 C CG1 . VAL A 1 44 ? 21.594 54.717 47.736 1.00 28.22 ? 110 VAL A CG1 1 ATOM 324 C CG2 . VAL A 1 44 ? 20.870 56.775 46.456 1.00 29.03 ? 110 VAL A CG2 1 ATOM 325 N N . TRP A 1 45 ? 24.281 53.500 46.086 1.00 27.78 ? 111 TRP A N 1 ATOM 326 C CA . TRP A 1 45 ? 24.790 52.136 46.112 1.00 27.37 ? 111 TRP A CA 1 ATOM 327 C C . TRP A 1 45 ? 25.427 51.835 47.450 1.00 29.38 ? 111 TRP A C 1 ATOM 328 O O . TRP A 1 45 ? 25.993 52.733 48.084 1.00 27.54 ? 111 TRP A O 1 ATOM 329 C CB . TRP A 1 45 ? 25.749 51.816 44.929 1.00 26.26 ? 111 TRP A CB 1 ATOM 330 C CG . TRP A 1 45 ? 27.089 52.503 44.972 1.00 27.18 ? 111 TRP A CG 1 ATOM 331 C CD1 . TRP A 1 45 ? 27.452 53.625 44.291 1.00 29.95 ? 111 TRP A CD1 1 ATOM 332 C CD2 . TRP A 1 45 ? 28.273 52.053 45.664 1.00 27.37 ? 111 TRP A CD2 1 ATOM 333 N NE1 . TRP A 1 45 ? 28.784 53.912 44.521 1.00 30.05 ? 111 TRP A NE1 1 ATOM 334 C CE2 . TRP A 1 45 ? 29.305 52.974 45.372 1.00 31.31 ? 111 TRP A CE2 1 ATOM 335 C CE3 . TRP A 1 45 ? 28.559 50.962 46.511 1.00 28.37 ? 111 TRP A CE3 1 ATOM 336 C CZ2 . TRP A 1 45 ? 30.592 52.848 45.899 1.00 30.85 ? 111 TRP A CZ2 1 ATOM 337 C CZ3 . TRP A 1 45 ? 29.831 50.848 47.047 1.00 29.55 ? 111 TRP A CZ3 1 ATOM 338 C CH2 . TRP A 1 45 ? 30.833 51.778 46.735 1.00 30.54 ? 111 TRP A CH2 1 ATOM 339 N N . VAL A 1 46 ? 25.381 50.557 47.842 1.00 24.65 ? 112 VAL A N 1 ATOM 340 C CA . VAL A 1 46 ? 26.003 50.020 49.060 1.00 23.65 ? 112 VAL A CA 1 ATOM 341 C C . VAL A 1 46 ? 26.572 48.644 48.683 1.00 28.34 ? 112 VAL A C 1 ATOM 342 O O . VAL A 1 46 ? 26.051 48.013 47.731 1.00 27.72 ? 112 VAL A O 1 ATOM 343 C CB . VAL A 1 46 ? 25.000 49.911 50.263 1.00 26.12 ? 112 VAL A CB 1 ATOM 344 C CG1 . VAL A 1 46 ? 24.678 51.283 50.842 1.00 25.94 ? 112 VAL A CG1 1 ATOM 345 C CG2 . VAL A 1 46 ? 23.713 49.156 49.871 1.00 25.36 ? 112 VAL A CG2 1 ATOM 346 N N . PRO A 1 47 ? 27.576 48.101 49.427 1.00 24.57 ? 113 PRO A N 1 ATOM 347 C CA . PRO A 1 47 ? 28.050 46.739 49.107 1.00 23.64 ? 113 PRO A CA 1 ATOM 348 C C . PRO A 1 47 ? 26.950 45.708 49.411 1.00 26.37 ? 113 PRO A C 1 ATOM 349 O O . PRO A 1 47 ? 26.125 45.916 50.311 1.00 24.74 ? 113 PRO A O 1 ATOM 350 C CB . PRO A 1 47 ? 29.285 46.587 50.000 1.00 25.08 ? 113 PRO A CB 1 ATOM 351 C CG . PRO A 1 47 ? 29.635 47.976 50.439 1.00 28.62 ? 113 PRO A CG 1 ATOM 352 C CD . PRO A 1 47 ? 28.310 48.638 50.588 1.00 24.74 ? 113 PRO A CD 1 ATOM 353 N N . SER A 1 48 ? 26.927 44.615 48.649 1.00 24.34 ? 114 SER A N 1 ATOM 354 C CA . SER A 1 48 ? 25.901 43.586 48.733 1.00 25.39 ? 114 SER A CA 1 ATOM 355 C C . SER A 1 48 ? 26.367 42.336 49.493 1.00 31.71 ? 114 SER A C 1 ATOM 356 O O . SER A 1 48 ? 27.553 42.026 49.494 1.00 31.95 ? 114 SER A O 1 ATOM 357 C CB . SER A 1 48 ? 25.469 43.204 47.313 1.00 29.11 ? 114 SER A CB 1 ATOM 358 O OG . SER A 1 48 ? 24.485 42.187 47.270 1.00 30.05 ? 114 SER A OG 1 ATOM 359 N N . SER A 1 49 ? 25.421 41.580 50.081 1.00 28.66 ? 115 SER A N 1 ATOM 360 C CA . SER A 1 49 ? 25.756 40.298 50.731 1.00 28.23 ? 115 SER A CA 1 ATOM 361 C C . SER A 1 49 ? 26.096 39.279 49.627 1.00 32.64 ? 115 SER A C 1 ATOM 362 O O . SER A 1 49 ? 26.749 38.282 49.878 1.00 32.69 ? 115 SER A O 1 ATOM 363 C CB . SER A 1 49 ? 24.589 39.772 51.572 1.00 29.01 ? 115 SER A CB 1 ATOM 364 O OG . SER A 1 49 ? 23.399 39.647 50.808 1.00 33.78 ? 115 SER A OG 1 ATOM 365 N N . LYS A 1 50 ? 25.665 39.556 48.395 1.00 31.63 ? 116 LYS A N 1 ATOM 366 C CA . LYS A 1 50 ? 25.911 38.716 47.218 1.00 31.44 ? 116 LYS A CA 1 ATOM 367 C C . LYS A 1 50 ? 27.294 39.007 46.597 1.00 33.63 ? 116 LYS A C 1 ATOM 368 O O . LYS A 1 50 ? 27.654 38.371 45.614 1.00 32.99 ? 116 LYS A O 1 ATOM 369 C CB . LYS A 1 50 ? 24.749 38.862 46.216 1.00 33.34 ? 116 LYS A CB 1 ATOM 370 C CG . LYS A 1 50 ? 23.434 38.366 46.832 1.00 40.72 ? 116 LYS A CG 1 ATOM 371 C CD . LYS A 1 50 ? 22.195 38.709 46.047 1.00 52.35 ? 116 LYS A CD 1 ATOM 372 C CE . LYS A 1 50 ? 20.936 38.130 46.685 1.00 51.56 ? 116 LYS A CE 1 ATOM 373 N NZ . LYS A 1 50 ? 20.415 38.967 47.807 1.00 46.21 ? 116 LYS A NZ 1 ATOM 374 N N . CYS A 1 51 ? 28.083 39.917 47.213 1.00 30.49 ? 117 CYS A N 1 ATOM 375 C CA . CYS A 1 51 ? 29.444 40.235 46.772 1.00 31.16 ? 117 CYS A CA 1 ATOM 376 C C . CYS A 1 51 ? 30.383 39.092 47.143 1.00 38.86 ? 117 CYS A C 1 ATOM 377 O O . CYS A 1 51 ? 30.435 38.730 48.314 1.00 38.23 ? 117 CYS A O 1 ATOM 378 C CB . CYS A 1 51 ? 29.938 41.552 47.369 1.00 30.12 ? 117 CYS A CB 1 ATOM 379 S SG . CYS A 1 51 ? 31.640 41.979 46.882 1.00 33.15 ? 117 CYS A SG 1 ATOM 380 N N . SER A 1 52 ? 31.171 38.574 46.173 1.00 38.31 ? 118 SER A N 1 ATOM 381 C CA . SER A 1 52 ? 32.139 37.508 46.440 1.00 38.69 ? 118 SER A CA 1 ATOM 382 C C . SER A 1 52 ? 33.167 37.959 47.439 1.00 41.93 ? 118 SER A C 1 ATOM 383 O O . SER A 1 52 ? 33.745 39.040 47.285 1.00 41.00 ? 118 SER A O 1 ATOM 384 C CB . SER A 1 52 ? 32.842 37.064 45.164 1.00 43.88 ? 118 SER A CB 1 ATOM 385 O OG . SER A 1 52 ? 33.877 36.149 45.495 1.00 51.10 ? 118 SER A OG 1 ATOM 386 N N . ARG A 1 53 ? 33.398 37.121 48.469 1.00 38.93 ? 119 ARG A N 1 ATOM 387 C CA . ARG A 1 53 ? 34.362 37.376 49.552 1.00 37.88 ? 119 ARG A CA 1 ATOM 388 C C . ARG A 1 53 ? 35.808 37.312 49.052 1.00 38.22 ? 119 ARG A C 1 ATOM 389 O O . ARG A 1 53 ? 36.729 37.572 49.813 1.00 37.17 ? 119 ARG A O 1 ATOM 390 C CB . ARG A 1 53 ? 34.096 36.484 50.779 1.00 40.89 ? 119 ARG A CB 1 ATOM 391 C CG . ARG A 1 53 ? 32.636 36.503 51.302 1.00 52.55 ? 119 ARG A CG 1 ATOM 392 C CD . ARG A 1 53 ? 32.108 37.898 51.658 1.00 59.11 ? 119 ARG A CD 1 ATOM 393 N NE . ARG A 1 53 ? 30.869 37.861 52.445 1.00 66.86 ? 119 ARG A NE 1 ATOM 394 C CZ . ARG A 1 53 ? 29.640 37.745 51.936 1.00 76.35 ? 119 ARG A CZ 1 ATOM 395 N NH1 . ARG A 1 53 ? 29.464 37.612 50.627 1.00 60.10 ? 119 ARG A NH1 1 ATOM 396 N NH2 . ARG A 1 53 ? 28.583 37.739 52.735 1.00 56.59 ? 119 ARG A NH2 1 ATOM 397 N N . LEU A 1 54 ? 35.988 37.049 47.739 1.00 34.36 ? 120 LEU A N 1 ATOM 398 C CA . LEU A 1 54 ? 37.227 37.154 47.003 1.00 34.04 ? 120 LEU A CA 1 ATOM 399 C C . LEU A 1 54 ? 37.514 38.656 46.731 1.00 38.02 ? 120 LEU A C 1 ATOM 400 O O . LEU A 1 54 ? 38.673 39.003 46.480 1.00 39.02 ? 120 LEU A O 1 ATOM 401 C CB . LEU A 1 54 ? 37.168 36.350 45.708 1.00 34.84 ? 120 LEU A CB 1 ATOM 402 C CG . LEU A 1 54 ? 37.400 34.830 45.870 1.00 39.92 ? 120 LEU A CG 1 ATOM 403 C CD1 . LEU A 1 54 ? 36.997 34.094 44.608 1.00 40.02 ? 120 LEU A CD1 1 ATOM 404 C CD2 . LEU A 1 54 ? 38.839 34.511 46.286 1.00 38.82 ? 120 LEU A CD2 1 ATOM 405 N N . TYR A 1 55 ? 36.469 39.553 46.820 1.00 31.44 ? 121 TYR A N 1 ATOM 406 C CA . TYR A 1 55 ? 36.662 41.005 46.802 1.00 30.22 ? 121 TYR A CA 1 ATOM 407 C C . TYR A 1 55 ? 36.831 41.365 48.278 1.00 33.79 ? 121 TYR A C 1 ATOM 408 O O . TYR A 1 55 ? 35.841 41.393 49.021 1.00 31.94 ? 121 TYR A O 1 ATOM 409 C CB . TYR A 1 55 ? 35.476 41.793 46.228 1.00 30.37 ? 121 TYR A CB 1 ATOM 410 C CG . TYR A 1 55 ? 35.308 41.632 44.742 1.00 32.15 ? 121 TYR A CG 1 ATOM 411 C CD1 . TYR A 1 55 ? 36.066 42.389 43.846 1.00 33.43 ? 121 TYR A CD1 1 ATOM 412 C CD2 . TYR A 1 55 ? 34.365 40.751 44.222 1.00 33.14 ? 121 TYR A CD2 1 ATOM 413 C CE1 . TYR A 1 55 ? 35.895 42.257 42.470 1.00 33.29 ? 121 TYR A CE1 1 ATOM 414 C CE2 . TYR A 1 55 ? 34.221 40.576 42.847 1.00 34.43 ? 121 TYR A CE2 1 ATOM 415 C CZ . TYR A 1 55 ? 34.994 41.324 41.975 1.00 44.16 ? 121 TYR A CZ 1 ATOM 416 O OH . TYR A 1 55 ? 34.832 41.150 40.621 1.00 51.89 ? 121 TYR A OH 1 ATOM 417 N N . THR A 1 56 ? 38.087 41.626 48.703 1.00 30.77 ? 122 THR A N 1 ATOM 418 C CA . THR A 1 56 ? 38.442 41.927 50.104 1.00 29.96 ? 122 THR A CA 1 ATOM 419 C C . THR A 1 56 ? 37.782 43.202 50.629 1.00 33.70 ? 122 THR A C 1 ATOM 420 O O . THR A 1 56 ? 37.506 43.266 51.822 1.00 35.67 ? 122 THR A O 1 ATOM 421 C CB . THR A 1 56 ? 39.961 41.917 50.272 1.00 34.36 ? 122 THR A CB 1 ATOM 422 O OG1 . THR A 1 56 ? 40.432 40.752 49.594 1.00 31.99 ? 122 THR A OG1 1 ATOM 423 C CG2 . THR A 1 56 ? 40.404 41.886 51.769 1.00 28.47 ? 122 THR A CG2 1 ATOM 424 N N . ALA A 1 57 ? 37.494 44.192 49.760 1.00 29.45 ? 123 ALA A N 1 ATOM 425 C CA . ALA A 1 57 ? 36.765 45.404 50.152 1.00 27.96 ? 123 ALA A CA 1 ATOM 426 C C . ALA A 1 57 ? 35.394 45.001 50.687 1.00 31.26 ? 123 ALA A C 1 ATOM 427 O O . ALA A 1 57 ? 34.925 45.633 51.614 1.00 31.18 ? 123 ALA A O 1 ATOM 428 C CB . ALA A 1 57 ? 36.615 46.365 48.973 1.00 27.95 ? 123 ALA A CB 1 ATOM 429 N N . CYS A 1 58 ? 34.783 43.915 50.170 1.00 29.10 ? 124 CYS A N 1 ATOM 430 C CA . CYS A 1 58 ? 33.494 43.430 50.676 1.00 29.34 ? 124 CYS A CA 1 ATOM 431 C C . CYS A 1 58 ? 33.593 42.809 52.064 1.00 35.77 ? 124 CYS A C 1 ATOM 432 O O . CYS A 1 58 ? 32.716 43.055 52.886 1.00 37.85 ? 124 CYS A O 1 ATOM 433 C CB . CYS A 1 58 ? 32.807 42.505 49.680 1.00 29.21 ? 124 CYS A CB 1 ATOM 434 S SG . CYS A 1 58 ? 32.169 43.377 48.237 1.00 33.01 ? 124 CYS A SG 1 ATOM 435 N N . VAL A 1 59 ? 34.692 42.087 52.353 1.00 31.11 ? 125 VAL A N 1 ATOM 436 C CA . VAL A 1 59 ? 35.003 41.488 53.659 1.00 29.95 ? 125 VAL A CA 1 ATOM 437 C C . VAL A 1 59 ? 35.141 42.612 54.726 1.00 34.47 ? 125 VAL A C 1 ATOM 438 O O . VAL A 1 59 ? 34.739 42.414 55.868 1.00 35.96 ? 125 VAL A O 1 ATOM 439 C CB . VAL A 1 59 ? 36.319 40.645 53.552 1.00 33.22 ? 125 VAL A CB 1 ATOM 440 C CG1 . VAL A 1 59 ? 36.731 40.047 54.892 1.00 32.35 ? 125 VAL A CG1 1 ATOM 441 C CG2 . VAL A 1 59 ? 36.188 39.542 52.513 1.00 33.39 ? 125 VAL A CG2 1 ATOM 442 N N . TYR A 1 60 ? 35.671 43.796 54.333 1.00 29.84 ? 126 TYR A N 1 ATOM 443 C CA . TYR A 1 60 ? 35.963 44.930 55.232 1.00 29.29 ? 126 TYR A CA 1 ATOM 444 C C . TYR A 1 60 ? 34.909 46.026 55.249 1.00 30.79 ? 126 TYR A C 1 ATOM 445 O O . TYR A 1 60 ? 35.117 47.101 55.818 1.00 29.20 ? 126 TYR A O 1 ATOM 446 C CB . TYR A 1 60 ? 37.340 45.508 54.912 1.00 31.85 ? 126 TYR A CB 1 ATOM 447 C CG . TYR A 1 60 ? 38.462 44.640 55.437 1.00 33.89 ? 126 TYR A CG 1 ATOM 448 C CD1 . TYR A 1 60 ? 38.872 43.498 54.746 1.00 34.06 ? 126 TYR A CD1 1 ATOM 449 C CD2 . TYR A 1 60 ? 39.086 44.930 56.646 1.00 35.46 ? 126 TYR A CD2 1 ATOM 450 C CE1 . TYR A 1 60 ? 39.900 42.689 55.231 1.00 31.96 ? 126 TYR A CE1 1 ATOM 451 C CE2 . TYR A 1 60 ? 40.124 44.135 57.132 1.00 36.91 ? 126 TYR A CE2 1 ATOM 452 C CZ . TYR A 1 60 ? 40.529 43.019 56.419 1.00 40.13 ? 126 TYR A CZ 1 ATOM 453 O OH . TYR A 1 60 ? 41.540 42.242 56.922 1.00 43.61 ? 126 TYR A OH 1 ATOM 454 N N . HIS A 1 61 ? 33.743 45.713 54.703 1.00 26.90 ? 127 HIS A N 1 ATOM 455 C CA . HIS A 1 61 ? 32.648 46.658 54.688 1.00 25.88 ? 127 HIS A CA 1 ATOM 456 C C . HIS A 1 61 ? 31.309 46.014 55.078 1.00 30.39 ? 127 HIS A C 1 ATOM 457 O O . HIS A 1 61 ? 31.171 44.787 55.108 1.00 31.07 ? 127 HIS A O 1 ATOM 458 C CB . HIS A 1 61 ? 32.575 47.372 53.327 1.00 25.75 ? 127 HIS A CB 1 ATOM 459 C CG . HIS A 1 61 ? 33.622 48.424 53.157 1.00 28.02 ? 127 HIS A CG 1 ATOM 460 N ND1 . HIS A 1 61 ? 34.763 48.189 52.413 1.00 29.56 ? 127 HIS A ND1 1 ATOM 461 C CD2 . HIS A 1 61 ? 33.667 49.685 53.643 1.00 28.31 ? 127 HIS A CD2 1 ATOM 462 C CE1 . HIS A 1 61 ? 35.462 49.308 52.468 1.00 28.08 ? 127 HIS A CE1 1 ATOM 463 N NE2 . HIS A 1 61 ? 34.839 50.237 53.201 1.00 28.30 ? 127 HIS A NE2 1 ATOM 464 N N . LYS A 1 62 ? 30.362 46.857 55.456 1.00 26.90 ? 128 LYS A N 1 ATOM 465 C CA . LYS A 1 62 ? 28.998 46.470 55.792 1.00 26.96 ? 128 LYS A CA 1 ATOM 466 C C . LYS A 1 62 ? 28.305 46.062 54.473 1.00 30.69 ? 128 LYS A C 1 ATOM 467 O O . LYS A 1 62 ? 28.493 46.723 53.450 1.00 29.71 ? 128 LYS A O 1 ATOM 468 C CB . LYS A 1 62 ? 28.264 47.646 56.471 1.00 27.93 ? 128 LYS A CB 1 ATOM 469 C CG . LYS A 1 62 ? 26.893 47.284 57.051 1.00 40.38 ? 128 LYS A CG 1 ATOM 470 C CD . LYS A 1 62 ? 26.969 46.491 58.366 1.00 40.07 ? 128 LYS A CD 1 ATOM 471 C CE . LYS A 1 62 ? 25.750 46.723 59.200 1.00 42.65 ? 128 LYS A CE 1 ATOM 472 N NZ . LYS A 1 62 ? 25.767 48.077 59.858 1.00 46.65 ? 128 LYS A NZ 1 ATOM 473 N N . LEU A 1 63 ? 27.579 44.938 54.486 1.00 27.71 ? 129 LEU A N 1 ATOM 474 C CA . LEU A 1 63 ? 26.912 44.405 53.290 1.00 27.07 ? 129 LEU A CA 1 ATOM 475 C C . LEU A 1 63 ? 25.405 44.355 53.467 1.00 32.22 ? 129 LEU A C 1 ATOM 476 O O . LEU A 1 63 ? 24.917 43.939 54.519 1.00 32.63 ? 129 LEU A O 1 ATOM 477 C CB . LEU A 1 63 ? 27.444 43.000 52.960 1.00 26.39 ? 129 LEU A CB 1 ATOM 478 C CG . LEU A 1 63 ? 28.958 42.805 52.919 1.00 29.18 ? 129 LEU A CG 1 ATOM 479 C CD1 . LEU A 1 63 ? 29.308 41.321 52.721 1.00 28.91 ? 129 LEU A CD1 1 ATOM 480 C CD2 . LEU A 1 63 ? 29.598 43.624 51.797 1.00 26.81 ? 129 LEU A CD2 1 ATOM 481 N N . PHE A 1 64 ? 24.667 44.782 52.441 1.00 29.48 ? 130 PHE A N 1 ATOM 482 C CA . PHE A 1 64 ? 23.211 44.739 52.458 1.00 28.29 ? 130 PHE A CA 1 ATOM 483 C C . PHE A 1 64 ? 22.740 43.324 52.221 1.00 32.96 ? 130 PHE A C 1 ATOM 484 O O . PHE A 1 64 ? 23.123 42.704 51.223 1.00 35.52 ? 130 PHE A O 1 ATOM 485 C CB . PHE A 1 64 ? 22.593 45.701 51.419 1.00 29.29 ? 130 PHE A CB 1 ATOM 486 C CG . PHE A 1 64 ? 21.069 45.694 51.420 1.00 29.74 ? 130 PHE A CG 1 ATOM 487 C CD1 . PHE A 1 64 ? 20.353 46.246 52.478 1.00 31.00 ? 130 PHE A CD1 1 ATOM 488 C CD2 . PHE A 1 64 ? 20.354 45.085 50.388 1.00 30.50 ? 130 PHE A CD2 1 ATOM 489 C CE1 . PHE A 1 64 ? 18.950 46.223 52.487 1.00 31.40 ? 130 PHE A CE1 1 ATOM 490 C CE2 . PHE A 1 64 ? 18.952 45.055 50.406 1.00 32.52 ? 130 PHE A CE2 1 ATOM 491 C CZ . PHE A 1 64 ? 18.259 45.631 51.454 1.00 29.84 ? 130 PHE A CZ 1 ATOM 492 N N . ASP A 1 65 ? 21.897 42.819 53.121 1.00 27.90 ? 131 ASP A N 1 ATOM 493 C CA . ASP A 1 65 ? 21.329 41.479 52.980 1.00 28.23 ? 131 ASP A CA 1 ATOM 494 C C . ASP A 1 65 ? 19.829 41.633 52.817 1.00 32.10 ? 131 ASP A C 1 ATOM 495 O O . ASP A 1 65 ? 19.127 41.973 53.786 1.00 29.88 ? 131 ASP A O 1 ATOM 496 C CB . ASP A 1 65 ? 21.690 40.576 54.191 1.00 29.61 ? 131 ASP A CB 1 ATOM 497 C CG . ASP A 1 65 ? 21.588 39.081 53.924 1.00 38.90 ? 131 ASP A CG 1 ATOM 498 O OD1 . ASP A 1 65 ? 20.819 38.683 52.994 1.00 37.25 ? 131 ASP A OD1 1 ATOM 499 O OD2 . ASP A 1 65 ? 22.278 38.304 54.630 1.00 46.71 ? 131 ASP A OD2 1 ATOM 500 N N . ALA A 1 66 ? 19.351 41.459 51.565 1.00 30.65 ? 132 ALA A N 1 ATOM 501 C CA . ALA A 1 66 ? 17.931 41.609 51.193 1.00 30.90 ? 132 ALA A CA 1 ATOM 502 C C . ALA A 1 66 ? 17.039 40.571 51.914 1.00 36.13 ? 132 ALA A C 1 ATOM 503 O O . ALA A 1 66 ? 15.865 40.847 52.205 1.00 35.01 ? 132 ALA A O 1 ATOM 504 C CB . ALA A 1 66 ? 17.771 41.478 49.686 1.00 31.26 ? 132 ALA A CB 1 ATOM 505 N N . SER A 1 67 ? 17.627 39.391 52.222 1.00 33.01 ? 133 SER A N 1 ATOM 506 C CA . SER A 1 67 ? 17.007 38.241 52.917 1.00 32.95 ? 133 SER A CA 1 ATOM 507 C C . SER A 1 67 ? 16.611 38.571 54.370 1.00 36.29 ? 133 SER A C 1 ATOM 508 O O . SER A 1 67 ? 15.859 37.815 54.971 1.00 36.78 ? 133 SER A O 1 ATOM 509 C CB . SER A 1 67 ? 17.948 37.033 52.897 1.00 36.15 ? 133 SER A CB 1 ATOM 510 O OG . SER A 1 67 ? 18.047 36.437 51.614 1.00 47.84 ? 133 SER A OG 1 ATOM 511 N N . ASP A 1 68 ? 17.122 39.687 54.925 1.00 30.82 ? 134 ASP A N 1 ATOM 512 C CA . ASP A 1 68 ? 16.815 40.137 56.281 1.00 30.21 ? 134 ASP A CA 1 ATOM 513 C C . ASP A 1 68 ? 15.865 41.322 56.288 1.00 33.54 ? 134 ASP A C 1 ATOM 514 O O . ASP A 1 68 ? 15.563 41.843 57.357 1.00 35.48 ? 134 ASP A O 1 ATOM 515 C CB . ASP A 1 68 ? 18.110 40.494 57.031 1.00 32.09 ? 134 ASP A CB 1 ATOM 516 C CG . ASP A 1 68 ? 19.017 39.313 57.295 1.00 37.14 ? 134 ASP A CG 1 ATOM 517 O OD1 . ASP A 1 68 ? 18.508 38.186 57.392 1.00 37.50 ? 134 ASP A OD1 1 ATOM 518 O OD2 . ASP A 1 68 ? 20.225 39.523 57.441 1.00 47.65 ? 134 ASP A OD2 1 ATOM 519 N N . SER A 1 69 ? 15.393 41.752 55.110 1.00 28.80 ? 135 SER A N 1 ATOM 520 C CA . SER A 1 69 ? 14.497 42.899 54.957 1.00 28.59 ? 135 SER A CA 1 ATOM 521 C C . SER A 1 69 ? 13.111 42.505 54.429 1.00 35.38 ? 135 SER A C 1 ATOM 522 O O . SER A 1 69 ? 12.995 41.891 53.362 1.00 35.03 ? 135 SER A O 1 ATOM 523 C CB . SER A 1 69 ? 15.125 43.963 54.069 1.00 28.50 ? 135 SER A CB 1 ATOM 524 O OG . SER A 1 69 ? 14.251 45.068 53.959 1.00 36.22 ? 135 SER A OG 1 ATOM 525 N N . SER A 1 70 ? 12.059 42.868 55.195 1.00 33.08 ? 136 SER A N 1 ATOM 526 C CA . SER A 1 70 ? 10.670 42.567 54.854 1.00 32.73 ? 136 SER A CA 1 ATOM 527 C C . SER A 1 70 ? 10.093 43.552 53.837 1.00 37.03 ? 136 SER A C 1 ATOM 528 O O . SER A 1 70 ? 9.124 43.209 53.146 1.00 38.74 ? 136 SER A O 1 ATOM 529 C CB . SER A 1 70 ? 9.806 42.518 56.109 1.00 35.51 ? 136 SER A CB 1 ATOM 530 O OG . SER A 1 70 ? 9.637 43.788 56.708 1.00 46.90 ? 136 SER A OG 1 ATOM 531 N N . SER A 1 71 ? 10.718 44.745 53.710 1.00 30.86 ? 137 SER A N 1 ATOM 532 C CA . SER A 1 71 ? 10.274 45.829 52.816 1.00 30.38 ? 137 SER A CA 1 ATOM 533 C C . SER A 1 71 ? 10.965 45.825 51.441 1.00 36.03 ? 137 SER A C 1 ATOM 534 O O . SER A 1 71 ? 10.647 46.654 50.581 1.00 36.04 ? 137 SER A O 1 ATOM 535 C CB . SER A 1 71 ? 10.449 47.183 53.499 1.00 32.29 ? 137 SER A CB 1 ATOM 536 O OG . SER A 1 71 ? 11.711 47.249 54.148 1.00 37.35 ? 137 SER A OG 1 ATOM 537 N N . TYR A 1 72 ? 11.910 44.896 51.240 1.00 31.82 ? 138 TYR A N 1 ATOM 538 C CA . TYR A 1 72 ? 12.657 44.776 50.003 1.00 31.32 ? 138 TYR A CA 1 ATOM 539 C C . TYR A 1 72 ? 11.762 44.371 48.820 1.00 37.45 ? 138 TYR A C 1 ATOM 540 O O . TYR A 1 72 ? 10.837 43.551 48.977 1.00 37.84 ? 138 TYR A O 1 ATOM 541 C CB . TYR A 1 72 ? 13.825 43.794 50.219 1.00 31.27 ? 138 TYR A CB 1 ATOM 542 C CG . TYR A 1 72 ? 14.418 43.183 48.977 1.00 31.42 ? 138 TYR A CG 1 ATOM 543 C CD1 . TYR A 1 72 ? 15.351 43.882 48.209 1.00 33.13 ? 138 TYR A CD1 1 ATOM 544 C CD2 . TYR A 1 72 ? 14.098 41.881 48.596 1.00 31.01 ? 138 TYR A CD2 1 ATOM 545 C CE1 . TYR A 1 72 ? 15.927 43.311 47.075 1.00 31.35 ? 138 TYR A CE1 1 ATOM 546 C CE2 . TYR A 1 72 ? 14.665 41.300 47.460 1.00 31.81 ? 138 TYR A CE2 1 ATOM 547 C CZ . TYR A 1 72 ? 15.587 42.017 46.711 1.00 37.56 ? 138 TYR A CZ 1 ATOM 548 O OH . TYR A 1 72 ? 16.190 41.432 45.631 1.00 36.75 ? 138 TYR A OH 1 ATOM 549 N N . LYS A 1 73 ? 12.029 44.977 47.646 1.00 32.82 ? 139 LYS A N 1 ATOM 550 C CA . LYS A 1 73 ? 11.344 44.671 46.381 1.00 32.71 ? 139 LYS A CA 1 ATOM 551 C C . LYS A 1 73 ? 12.423 44.399 45.345 1.00 35.54 ? 139 LYS A C 1 ATOM 552 O O . LYS A 1 73 ? 13.268 45.262 45.081 1.00 36.86 ? 139 LYS A O 1 ATOM 553 C CB . LYS A 1 73 ? 10.398 45.817 45.913 1.00 34.85 ? 139 LYS A CB 1 ATOM 554 C CG . LYS A 1 73 ? 9.335 46.256 46.918 1.00 29.32 ? 139 LYS A CG 1 ATOM 555 C CD . LYS A 1 73 ? 8.146 45.314 46.979 1.00 34.76 ? 139 LYS A CD 1 ATOM 556 C CE . LYS A 1 73 ? 6.973 45.929 47.702 1.00 47.72 ? 139 LYS A CE 1 ATOM 557 N NZ . LYS A 1 73 ? 7.122 45.858 49.184 1.00 66.00 ? 139 LYS A NZ 1 ATOM 558 N N . HIS A 1 74 ? 12.421 43.200 44.799 1.00 31.25 ? 140 HIS A N 1 ATOM 559 C CA . HIS A 1 74 ? 13.394 42.739 43.816 1.00 32.90 ? 140 HIS A CA 1 ATOM 560 C C . HIS A 1 74 ? 13.350 43.501 42.483 1.00 39.71 ? 140 HIS A C 1 ATOM 561 O O . HIS A 1 74 ? 12.266 43.845 42.010 1.00 41.06 ? 140 HIS A O 1 ATOM 562 C CB . HIS A 1 74 ? 13.227 41.219 43.597 1.00 33.37 ? 140 HIS A CB 1 ATOM 563 C CG . HIS A 1 74 ? 13.813 40.698 42.321 1.00 37.59 ? 140 HIS A CG 1 ATOM 564 N ND1 . HIS A 1 74 ? 13.033 40.581 41.165 1.00 39.92 ? 140 HIS A ND1 1 ATOM 565 C CD2 . HIS A 1 74 ? 15.075 40.295 42.036 1.00 39.36 ? 140 HIS A CD2 1 ATOM 566 C CE1 . HIS A 1 74 ? 13.837 40.077 40.238 1.00 39.23 ? 140 HIS A CE1 1 ATOM 567 N NE2 . HIS A 1 74 ? 15.079 39.900 40.708 1.00 39.16 ? 140 HIS A NE2 1 ATOM 568 N N . ASN A 1 75 ? 14.523 43.725 41.869 1.00 35.17 ? 141 ASN A N 1 ATOM 569 C CA . ASN A 1 75 ? 14.613 44.287 40.532 1.00 34.47 ? 141 ASN A CA 1 ATOM 570 C C . ASN A 1 75 ? 15.585 43.457 39.691 1.00 38.05 ? 141 ASN A C 1 ATOM 571 O O . ASN A 1 75 ? 15.151 42.778 38.757 1.00 38.20 ? 141 ASN A O 1 ATOM 572 C CB . ASN A 1 75 ? 14.885 45.780 40.503 1.00 37.08 ? 141 ASN A CB 1 ATOM 573 C CG . ASN A 1 75 ? 14.754 46.324 39.100 1.00 53.32 ? 141 ASN A CG 1 ATOM 574 O OD1 . ASN A 1 75 ? 15.721 46.339 38.347 1.00 38.42 ? 141 ASN A OD1 1 ATOM 575 N ND2 . ASN A 1 75 ? 13.550 46.717 38.706 1.00 54.48 ? 141 ASN A ND2 1 ATOM 576 N N . GLY A 1 76 ? 16.860 43.465 40.062 1.00 33.32 ? 142 GLY A N 1 ATOM 577 C CA . GLY A 1 76 ? 17.878 42.644 39.419 1.00 32.86 ? 142 GLY A CA 1 ATOM 578 C C . GLY A 1 76 ? 18.568 43.165 38.174 1.00 37.16 ? 142 GLY A C 1 ATOM 579 O O . GLY A 1 76 ? 19.483 42.504 37.673 1.00 35.59 ? 142 GLY A O 1 ATOM 580 N N . THR A 1 77 ? 18.136 44.322 37.645 1.00 34.70 ? 143 THR A N 1 ATOM 581 C CA . THR A 1 77 ? 18.770 44.920 36.463 1.00 34.97 ? 143 THR A CA 1 ATOM 582 C C . THR A 1 77 ? 20.240 45.226 36.789 1.00 38.75 ? 143 THR A C 1 ATOM 583 O O . THR A 1 77 ? 20.524 45.811 37.830 1.00 35.14 ? 143 THR A O 1 ATOM 584 C CB . THR A 1 77 ? 18.035 46.217 36.057 1.00 40.38 ? 143 THR A CB 1 ATOM 585 O OG1 . THR A 1 77 ? 16.670 45.909 35.806 1.00 39.44 ? 143 THR A OG1 1 ATOM 586 C CG2 . THR A 1 77 ? 18.650 46.895 34.846 1.00 35.15 ? 143 THR A CG2 1 ATOM 587 N N . GLU A 1 78 ? 21.158 44.824 35.891 1.00 38.84 ? 144 GLU A N 1 ATOM 588 C CA . GLU A 1 78 ? 22.594 45.052 36.015 1.00 38.52 ? 144 GLU A CA 1 ATOM 589 C C . GLU A 1 78 ? 22.895 46.550 36.025 1.00 40.93 ? 144 GLU A C 1 ATOM 590 O O . GLU A 1 78 ? 22.195 47.341 35.401 1.00 40.68 ? 144 GLU A O 1 ATOM 591 C CB . GLU A 1 78 ? 23.348 44.363 34.876 1.00 40.61 ? 144 GLU A CB 1 ATOM 592 C CG . GLU A 1 78 ? 24.789 44.030 35.229 1.00 62.95 ? 144 GLU A CG 1 ATOM 593 C CD . GLU A 1 78 ? 25.865 44.590 34.312 1.00 99.35 ? 144 GLU A CD 1 ATOM 594 O OE1 . GLU A 1 78 ? 26.427 45.666 34.630 1.00 76.29 ? 144 GLU A OE1 1 ATOM 595 O OE2 . GLU A 1 78 ? 26.169 43.932 33.288 1.00 104.14 ? 144 GLU A OE2 1 ATOM 596 N N . LEU A 1 79 ? 23.932 46.932 36.768 1.00 36.96 ? 145 LEU A N 1 ATOM 597 C CA . LEU A 1 79 ? 24.355 48.306 36.931 1.00 35.55 ? 145 LEU A CA 1 ATOM 598 C C . LEU A 1 79 ? 25.870 48.351 37.029 1.00 37.91 ? 145 LEU A C 1 ATOM 599 O O . LEU A 1 79 ? 26.458 47.610 37.810 1.00 37.41 ? 145 LEU A O 1 ATOM 600 C CB . LEU A 1 79 ? 23.711 48.869 38.222 1.00 35.79 ? 145 LEU A CB 1 ATOM 601 C CG . LEU A 1 79 ? 24.105 50.280 38.652 1.00 41.04 ? 145 LEU A CG 1 ATOM 602 C CD1 . LEU A 1 79 ? 23.465 51.328 37.751 1.00 41.39 ? 145 LEU A CD1 1 ATOM 603 C CD2 . LEU A 1 79 ? 23.690 50.529 40.079 1.00 41.88 ? 145 LEU A CD2 1 ATOM 604 N N . THR A 1 80 ? 26.496 49.215 36.230 1.00 34.76 ? 146 THR A N 1 ATOM 605 C CA . THR A 1 80 ? 27.932 49.447 36.259 1.00 34.61 ? 146 THR A CA 1 ATOM 606 C C . THR A 1 80 ? 28.117 50.948 36.469 1.00 37.12 ? 146 THR A C 1 ATOM 607 O O . THR A 1 80 ? 27.509 51.732 35.746 1.00 36.06 ? 146 THR A O 1 ATOM 608 C CB . THR A 1 80 ? 28.651 48.866 35.012 1.00 41.97 ? 146 THR A CB 1 ATOM 609 O OG1 . THR A 1 80 ? 28.470 47.440 34.984 1.00 45.91 ? 146 THR A OG1 1 ATOM 610 C CG2 . THR A 1 80 ? 30.145 49.164 35.008 1.00 35.77 ? 146 THR A CG2 1 ATOM 611 N N . LEU A 1 81 ? 28.919 51.336 37.494 1.00 32.43 ? 147 LEU A N 1 ATOM 612 C CA . LEU A 1 81 ? 29.205 52.740 37.820 1.00 32.16 ? 147 LEU A CA 1 ATOM 613 C C . LEU A 1 81 ? 30.688 53.004 37.634 1.00 36.62 ? 147 LEU A C 1 ATOM 614 O O . LEU A 1 81 ? 31.512 52.567 38.447 1.00 34.18 ? 147 LEU A O 1 ATOM 615 C CB . LEU A 1 81 ? 28.746 53.117 39.254 1.00 32.00 ? 147 LEU A CB 1 ATOM 616 C CG . LEU A 1 81 ? 27.298 52.811 39.603 1.00 36.02 ? 147 LEU A CG 1 ATOM 617 C CD1 . LEU A 1 81 ? 27.032 53.055 41.034 1.00 35.93 ? 147 LEU A CD1 1 ATOM 618 C CD2 . LEU A 1 81 ? 26.357 53.670 38.783 1.00 38.80 ? 147 LEU A CD2 1 ATOM 619 N N . ARG A 1 82 ? 31.023 53.681 36.528 1.00 35.99 ? 148 ARG A N 1 ATOM 620 C CA . ARG A 1 82 ? 32.402 54.006 36.175 1.00 37.45 ? 148 ARG A CA 1 ATOM 621 C C . ARG A 1 82 ? 32.724 55.393 36.649 1.00 41.86 ? 148 ARG A C 1 ATOM 622 O O . ARG A 1 82 ? 32.221 56.366 36.095 1.00 42.07 ? 148 ARG A O 1 ATOM 623 C CB . ARG A 1 82 ? 32.662 53.872 34.656 1.00 37.81 ? 148 ARG A CB 1 ATOM 624 C CG . ARG A 1 82 ? 32.654 52.463 34.124 1.00 46.52 ? 148 ARG A CG 1 ATOM 625 C CD . ARG A 1 82 ? 32.575 52.489 32.610 1.00 57.17 ? 148 ARG A CD 1 ATOM 626 N NE . ARG A 1 82 ? 32.264 51.170 32.050 1.00 64.88 ? 148 ARG A NE 1 ATOM 627 C CZ . ARG A 1 82 ? 31.036 50.720 31.802 1.00 70.21 ? 148 ARG A CZ 1 ATOM 628 N NH1 . ARG A 1 82 ? 29.977 51.472 32.074 1.00 47.30 ? 148 ARG A NH1 1 ATOM 629 N NH2 . ARG A 1 82 ? 30.858 49.508 31.295 1.00 61.52 ? 148 ARG A NH2 1 ATOM 630 N N . TYR A 1 83 ? 33.543 55.486 37.688 1.00 38.41 ? 149 TYR A N 1 ATOM 631 C CA . TYR A 1 83 ? 33.974 56.767 38.232 1.00 37.81 ? 149 TYR A CA 1 ATOM 632 C C . TYR A 1 83 ? 35.434 57.003 37.851 1.00 43.52 ? 149 TYR A C 1 ATOM 633 O O . TYR A 1 83 ? 36.132 56.079 37.409 1.00 42.95 ? 149 TYR A O 1 ATOM 634 C CB . TYR A 1 83 ? 33.861 56.801 39.775 1.00 37.87 ? 149 TYR A CB 1 ATOM 635 C CG . TYR A 1 83 ? 32.516 56.457 40.376 1.00 39.27 ? 149 TYR A CG 1 ATOM 636 C CD1 . TYR A 1 83 ? 31.419 57.297 40.209 1.00 40.28 ? 149 TYR A CD1 1 ATOM 637 C CD2 . TYR A 1 83 ? 32.375 55.367 41.231 1.00 39.74 ? 149 TYR A CD2 1 ATOM 638 C CE1 . TYR A 1 83 ? 30.196 57.014 40.815 1.00 40.58 ? 149 TYR A CE1 1 ATOM 639 C CE2 . TYR A 1 83 ? 31.158 55.067 41.834 1.00 40.43 ? 149 TYR A CE2 1 ATOM 640 C CZ . TYR A 1 83 ? 30.073 55.901 41.639 1.00 45.94 ? 149 TYR A CZ 1 ATOM 641 O OH . TYR A 1 83 ? 28.879 55.614 42.260 1.00 41.11 ? 149 TYR A OH 1 ATOM 642 N N . SER A 1 84 ? 35.916 58.226 38.125 1.00 40.81 ? 150 SER A N 1 ATOM 643 C CA . SER A 1 84 ? 37.285 58.670 37.893 1.00 40.70 ? 150 SER A CA 1 ATOM 644 C C . SER A 1 84 ? 38.306 57.953 38.801 1.00 43.83 ? 150 SER A C 1 ATOM 645 O O . SER A 1 84 ? 39.487 57.852 38.457 1.00 43.24 ? 150 SER A O 1 ATOM 646 C CB . SER A 1 84 ? 37.365 60.176 38.117 1.00 43.93 ? 150 SER A CB 1 ATOM 647 O OG . SER A 1 84 ? 36.444 60.834 37.261 1.00 54.73 ? 150 SER A OG 1 ATOM 648 N N . THR A 1 85 ? 37.857 57.475 39.966 1.00 39.82 ? 151 THR A N 1 ATOM 649 C CA . THR A 1 85 ? 38.751 56.836 40.934 1.00 39.07 ? 151 THR A CA 1 ATOM 650 C C . THR A 1 85 ? 38.734 55.299 40.864 1.00 39.20 ? 151 THR A C 1 ATOM 651 O O . THR A 1 85 ? 39.618 54.633 41.431 1.00 40.16 ? 151 THR A O 1 ATOM 652 C CB . THR A 1 85 ? 38.454 57.353 42.355 1.00 42.35 ? 151 THR A CB 1 ATOM 653 O OG1 . THR A 1 85 ? 37.065 57.203 42.605 1.00 41.97 ? 151 THR A OG1 1 ATOM 654 C CG2 . THR A 1 85 ? 38.860 58.790 42.546 1.00 39.71 ? 151 THR A CG2 1 ATOM 655 N N . GLY A 1 86 ? 37.744 54.771 40.180 1.00 32.45 ? 152 GLY A N 1 ATOM 656 C CA . GLY A 1 86 ? 37.534 53.342 40.044 1.00 33.61 ? 152 GLY A CA 1 ATOM 657 C C . GLY A 1 86 ? 36.100 53.011 39.650 1.00 40.29 ? 152 GLY A C 1 ATOM 658 O O . GLY A 1 86 ? 35.270 53.906 39.499 1.00 39.75 ? 152 GLY A O 1 ATOM 659 N N . THR A 1 87 ? 35.804 51.720 39.465 1.00 37.21 ? 153 THR A N 1 ATOM 660 C CA . THR A 1 87 ? 34.503 51.224 39.031 1.00 35.97 ? 153 THR A CA 1 ATOM 661 C C . THR A 1 87 ? 33.903 50.264 40.067 1.00 39.51 ? 153 THR A C 1 ATOM 662 O O . THR A 1 87 ? 34.626 49.583 40.783 1.00 41.17 ? 153 THR A O 1 ATOM 663 C CB . THR A 1 87 ? 34.686 50.574 37.657 1.00 36.22 ? 153 THR A CB 1 ATOM 664 O OG1 . THR A 1 87 ? 35.313 51.524 36.809 1.00 42.66 ? 153 THR A OG1 1 ATOM 665 C CG2 . THR A 1 87 ? 33.412 50.089 37.025 1.00 27.64 ? 153 THR A CG2 1 ATOM 666 N N . VAL A 1 88 ? 32.575 50.259 40.168 1.00 33.34 ? 154 VAL A N 1 ATOM 667 C CA . VAL A 1 88 ? 31.793 49.332 40.978 1.00 31.05 ? 154 VAL A CA 1 ATOM 668 C C . VAL A 1 88 ? 30.677 48.824 40.085 1.00 33.03 ? 154 VAL A C 1 ATOM 669 O O . VAL A 1 88 ? 30.214 49.544 39.197 1.00 32.25 ? 154 VAL A O 1 ATOM 670 C CB . VAL A 1 88 ? 31.234 49.897 42.314 1.00 33.45 ? 154 VAL A CB 1 ATOM 671 C CG1 . VAL A 1 88 ? 32.345 50.167 43.316 1.00 32.77 ? 154 VAL A CG1 1 ATOM 672 C CG2 . VAL A 1 88 ? 30.330 51.125 42.109 1.00 32.50 ? 154 VAL A CG2 1 ATOM 673 N N . SER A 1 89 ? 30.257 47.587 40.294 1.00 29.61 ? 155 SER A N 1 ATOM 674 C CA . SER A 1 89 ? 29.127 47.069 39.550 1.00 30.45 ? 155 SER A CA 1 ATOM 675 C C . SER A 1 89 ? 28.331 46.085 40.395 1.00 33.71 ? 155 SER A C 1 ATOM 676 O O . SER A 1 89 ? 28.789 45.622 41.448 1.00 32.47 ? 155 SER A O 1 ATOM 677 C CB . SER A 1 89 ? 29.490 46.537 38.152 1.00 32.84 ? 155 SER A CB 1 ATOM 678 O OG . SER A 1 89 ? 30.029 45.240 38.155 1.00 47.64 ? 155 SER A OG 1 ATOM 679 N N . GLY A 1 90 ? 27.100 45.886 39.966 1.00 28.94 ? 156 GLY A N 1 ATOM 680 C CA . GLY A 1 90 ? 26.172 44.981 40.606 1.00 28.67 ? 156 GLY A CA 1 ATOM 681 C C . GLY A 1 90 ? 24.836 45.046 39.928 1.00 34.15 ? 156 GLY A C 1 ATOM 682 O O . GLY A 1 90 ? 24.767 45.092 38.701 1.00 34.45 ? 156 GLY A O 1 ATOM 683 N N . PHE A 1 91 ? 23.777 45.101 40.726 1.00 32.11 ? 157 PHE A N 1 ATOM 684 C CA . PHE A 1 91 ? 22.396 45.091 40.253 1.00 31.06 ? 157 PHE A CA 1 ATOM 685 C C . PHE A 1 91 ? 21.499 46.008 41.095 1.00 33.35 ? 157 PHE A C 1 ATOM 686 O O . PHE A 1 91 ? 21.843 46.321 42.229 1.00 32.48 ? 157 PHE A O 1 ATOM 687 C CB . PHE A 1 91 ? 21.859 43.639 40.258 1.00 32.46 ? 157 PHE A CB 1 ATOM 688 C CG . PHE A 1 91 ? 21.825 42.999 41.633 1.00 33.24 ? 157 PHE A CG 1 ATOM 689 C CD1 . PHE A 1 91 ? 20.714 43.147 42.462 1.00 33.16 ? 157 PHE A CD1 1 ATOM 690 C CD2 . PHE A 1 91 ? 22.916 42.273 42.109 1.00 33.52 ? 157 PHE A CD2 1 ATOM 691 C CE1 . PHE A 1 91 ? 20.698 42.594 43.736 1.00 32.86 ? 157 PHE A CE1 1 ATOM 692 C CE2 . PHE A 1 91 ? 22.889 41.702 43.385 1.00 34.75 ? 157 PHE A CE2 1 ATOM 693 C CZ . PHE A 1 91 ? 21.788 41.878 44.190 1.00 32.22 ? 157 PHE A CZ 1 ATOM 694 N N . LEU A 1 92 ? 20.332 46.385 40.553 1.00 30.19 ? 158 LEU A N 1 ATOM 695 C CA . LEU A 1 92 ? 19.346 47.247 41.207 1.00 29.51 ? 158 LEU A CA 1 ATOM 696 C C . LEU A 1 92 ? 18.402 46.522 42.162 1.00 32.17 ? 158 LEU A C 1 ATOM 697 O O . LEU A 1 92 ? 17.938 45.416 41.868 1.00 30.98 ? 158 LEU A O 1 ATOM 698 C CB . LEU A 1 92 ? 18.532 48.010 40.160 1.00 29.21 ? 158 LEU A CB 1 ATOM 699 C CG . LEU A 1 92 ? 19.313 49.019 39.289 1.00 32.30 ? 158 LEU A CG 1 ATOM 700 C CD1 . LEU A 1 92 ? 18.430 49.543 38.157 1.00 30.73 ? 158 LEU A CD1 1 ATOM 701 C CD2 . LEU A 1 92 ? 19.854 50.168 40.126 1.00 34.38 ? 158 LEU A CD2 1 ATOM 702 N N . SER A 1 93 ? 18.097 47.177 43.301 1.00 27.84 ? 159 SER A N 1 ATOM 703 C CA . SER A 1 93 ? 17.173 46.696 44.339 1.00 27.42 ? 159 SER A CA 1 ATOM 704 C C . SER A 1 93 ? 16.362 47.857 44.854 1.00 32.16 ? 159 SER A C 1 ATOM 705 O O . SER A 1 93 ? 16.808 48.989 44.760 1.00 32.81 ? 159 SER A O 1 ATOM 706 C CB . SER A 1 93 ? 17.926 46.046 45.506 1.00 27.49 ? 159 SER A CB 1 ATOM 707 O OG . SER A 1 93 ? 18.501 44.821 45.096 1.00 33.72 ? 159 SER A OG 1 ATOM 708 N N . GLN A 1 94 ? 15.180 47.591 45.409 1.00 29.42 ? 160 GLN A N 1 ATOM 709 C CA . GLN A 1 94 ? 14.361 48.647 46.001 1.00 29.41 ? 160 GLN A CA 1 ATOM 710 C C . GLN A 1 94 ? 14.095 48.310 47.466 1.00 32.89 ? 160 GLN A C 1 ATOM 711 O O . GLN A 1 94 ? 13.844 47.148 47.820 1.00 31.90 ? 160 GLN A O 1 ATOM 712 C CB . GLN A 1 94 ? 13.024 48.824 45.244 1.00 30.56 ? 160 GLN A CB 1 ATOM 713 C CG . GLN A 1 94 ? 12.195 49.982 45.779 1.00 33.44 ? 160 GLN A CG 1 ATOM 714 C CD . GLN A 1 94 ? 10.758 49.856 45.375 1.00 59.84 ? 160 GLN A CD 1 ATOM 715 O OE1 . GLN A 1 94 ? 10.381 50.282 44.299 1.00 49.21 ? 160 GLN A OE1 1 ATOM 716 N NE2 . GLN A 1 94 ? 9.924 49.279 46.220 1.00 61.96 ? 160 GLN A NE2 1 ATOM 717 N N . ASP A 1 95 ? 14.163 49.327 48.307 1.00 29.99 ? 161 ASP A N 1 ATOM 718 C CA . ASP A 1 95 ? 13.869 49.222 49.728 1.00 30.50 ? 161 ASP A CA 1 ATOM 719 C C . ASP A 1 95 ? 13.640 50.614 50.297 1.00 35.78 ? 161 ASP A C 1 ATOM 720 O O . ASP A 1 95 ? 13.796 51.612 49.588 1.00 33.09 ? 161 ASP A O 1 ATOM 721 C CB . ASP A 1 95 ? 14.987 48.475 50.493 1.00 31.77 ? 161 ASP A CB 1 ATOM 722 C CG . ASP A 1 95 ? 14.461 47.592 51.620 1.00 35.77 ? 161 ASP A CG 1 ATOM 723 O OD1 . ASP A 1 95 ? 13.513 48.013 52.315 1.00 33.51 ? 161 ASP A OD1 1 ATOM 724 O OD2 . ASP A 1 95 ? 15.022 46.504 51.827 1.00 36.77 ? 161 ASP A OD2 1 ATOM 725 N N . ILE A 1 96 ? 13.264 50.669 51.577 1.00 36.25 ? 162 ILE A N 1 ATOM 726 C CA . ILE A 1 96 ? 13.054 51.910 52.309 1.00 36.55 ? 162 ILE A CA 1 ATOM 727 C C . ILE A 1 96 ? 14.383 52.386 52.854 1.00 37.58 ? 162 ILE A C 1 ATOM 728 O O . ILE A 1 96 ? 15.116 51.607 53.483 1.00 37.43 ? 162 ILE A O 1 ATOM 729 C CB . ILE A 1 96 ? 11.980 51.704 53.408 1.00 40.86 ? 162 ILE A CB 1 ATOM 730 C CG1 . ILE A 1 96 ? 10.579 51.550 52.755 1.00 41.42 ? 162 ILE A CG1 1 ATOM 731 C CG2 . ILE A 1 96 ? 11.982 52.872 54.412 1.00 42.56 ? 162 ILE A CG2 1 ATOM 732 C CD1 . ILE A 1 96 ? 9.582 50.747 53.621 1.00 55.38 ? 162 ILE A CD1 1 ATOM 733 N N . ILE A 1 97 ? 14.697 53.676 52.608 1.00 32.44 ? 163 ILE A N 1 ATOM 734 C CA . ILE A 1 97 ? 15.914 54.312 53.085 1.00 30.98 ? 163 ILE A CA 1 ATOM 735 C C . ILE A 1 97 ? 15.569 55.443 54.066 1.00 36.28 ? 163 ILE A C 1 ATOM 736 O O . ILE A 1 97 ? 14.732 56.280 53.766 1.00 36.95 ? 163 ILE A O 1 ATOM 737 C CB . ILE A 1 97 ? 16.868 54.770 51.921 1.00 32.92 ? 163 ILE A CB 1 ATOM 738 C CG1 . ILE A 1 97 ? 17.255 53.562 51.014 1.00 32.20 ? 163 ILE A CG1 1 ATOM 739 C CG2 . ILE A 1 97 ? 18.129 55.493 52.488 1.00 31.22 ? 163 ILE A CG2 1 ATOM 740 C CD1 . ILE A 1 97 ? 18.289 53.840 49.872 1.00 28.15 ? 163 ILE A CD1 1 ATOM 741 N N . THR A 1 98 ? 16.195 55.453 55.238 1.00 34.35 ? 164 THR A N 1 ATOM 742 C CA . THR A 1 98 ? 16.038 56.548 56.195 1.00 34.95 ? 164 THR A CA 1 ATOM 743 C C . THR A 1 98 ? 17.317 57.377 56.170 1.00 39.72 ? 164 THR A C 1 ATOM 744 O O . THR A 1 98 ? 18.413 56.835 56.293 1.00 39.04 ? 164 THR A O 1 ATOM 745 C CB . THR A 1 98 ? 15.606 56.109 57.621 1.00 46.45 ? 164 THR A CB 1 ATOM 746 O OG1 . THR A 1 98 ? 16.657 55.406 58.287 1.00 50.31 ? 164 THR A OG1 1 ATOM 747 C CG2 . THR A 1 98 ? 14.312 55.309 57.652 1.00 43.53 ? 164 THR A CG2 1 ATOM 748 N N . VAL A 1 99 ? 17.169 58.675 55.918 1.00 37.29 ? 165 VAL A N 1 ATOM 749 C CA . VAL A 1 99 ? 18.247 59.647 55.867 1.00 36.78 ? 165 VAL A CA 1 ATOM 750 C C . VAL A 1 99 ? 17.772 60.867 56.649 1.00 42.74 ? 165 VAL A C 1 ATOM 751 O O . VAL A 1 99 ? 16.771 61.475 56.288 1.00 42.14 ? 165 VAL A O 1 ATOM 752 C CB . VAL A 1 99 ? 18.767 59.936 54.419 1.00 40.16 ? 165 VAL A CB 1 ATOM 753 C CG1 . VAL A 1 99 ? 17.650 60.248 53.442 1.00 40.12 ? 165 VAL A CG1 1 ATOM 754 C CG2 . VAL A 1 99 ? 19.817 61.040 54.398 1.00 39.87 ? 165 VAL A CG2 1 ATOM 755 N N . GLY A 1 100 ? 18.448 61.148 57.760 1.00 42.02 ? 166 GLY A N 1 ATOM 756 C CA . GLY A 1 100 ? 18.136 62.243 58.678 1.00 42.77 ? 166 GLY A CA 1 ATOM 757 C C . GLY A 1 100 ? 16.701 62.288 59.189 1.00 48.84 ? 166 GLY A C 1 ATOM 758 O O . GLY A 1 100 ? 16.131 63.360 59.365 1.00 48.73 ? 166 GLY A O 1 ATOM 759 N N . GLY A 1 101 ? 16.083 61.151 59.415 1.00 47.60 ? 167 GLY A N 1 ATOM 760 C CA . GLY A 1 101 ? 14.698 61.200 59.869 1.00 49.30 ? 167 GLY A CA 1 ATOM 761 C C . GLY A 1 101 ? 13.670 61.156 58.753 1.00 54.76 ? 167 GLY A C 1 ATOM 762 O O . GLY A 1 101 ? 12.504 60.850 59.019 1.00 56.35 ? 167 GLY A O 1 ATOM 763 N N . ILE A 1 102 ? 14.073 61.495 57.500 1.00 48.63 ? 168 ILE A N 1 ATOM 764 C CA . ILE A 1 102 ? 13.199 61.350 56.324 1.00 46.37 ? 168 ILE A CA 1 ATOM 765 C C . ILE A 1 102 ? 13.307 59.882 55.851 1.00 48.97 ? 168 ILE A C 1 ATOM 766 O O . ILE A 1 102 ? 14.407 59.331 55.799 1.00 49.58 ? 168 ILE A O 1 ATOM 767 C CB . ILE A 1 102 ? 13.577 62.335 55.207 1.00 48.44 ? 168 ILE A CB 1 ATOM 768 C CG1 . ILE A 1 102 ? 13.349 63.787 55.652 1.00 47.13 ? 168 ILE A CG1 1 ATOM 769 C CG2 . ILE A 1 102 ? 12.848 61.995 53.864 1.00 49.19 ? 168 ILE A CG2 1 ATOM 770 C CD1 . ILE A 1 102 ? 13.919 64.843 54.695 1.00 49.24 ? 168 ILE A CD1 1 ATOM 771 N N . THR A 1 103 ? 12.163 59.254 55.540 1.00 43.13 ? 169 THR A N 1 ATOM 772 C CA . THR A 1 103 ? 12.044 57.880 55.059 1.00 41.53 ? 169 THR A CA 1 ATOM 773 C C . THR A 1 103 ? 11.607 57.981 53.615 1.00 44.38 ? 169 THR A C 1 ATOM 774 O O . THR A 1 103 ? 10.649 58.689 53.317 1.00 44.32 ? 169 THR A O 1 ATOM 775 C CB . THR A 1 103 ? 11.012 57.147 55.930 1.00 49.20 ? 169 THR A CB 1 ATOM 776 O OG1 . THR A 1 103 ? 11.462 57.053 57.278 1.00 54.14 ? 169 THR A OG1 1 ATOM 777 C CG2 . THR A 1 103 ? 10.622 55.800 55.413 1.00 48.77 ? 169 THR A CG2 1 ATOM 778 N N . VAL A 1 104 ? 12.286 57.275 52.715 1.00 40.31 ? 170 VAL A N 1 ATOM 779 C CA . VAL A 1 104 ? 11.966 57.314 51.288 1.00 39.44 ? 170 VAL A CA 1 ATOM 780 C C . VAL A 1 104 ? 12.112 55.918 50.642 1.00 42.78 ? 170 VAL A C 1 ATOM 781 O O . VAL A 1 104 ? 13.059 55.198 50.944 1.00 43.44 ? 170 VAL A O 1 ATOM 782 C CB . VAL A 1 104 ? 12.801 58.438 50.569 1.00 43.65 ? 170 VAL A CB 1 ATOM 783 C CG1 . VAL A 1 104 ? 14.307 58.227 50.718 1.00 43.60 ? 170 VAL A CG1 1 ATOM 784 C CG2 . VAL A 1 104 ? 12.418 58.594 49.107 1.00 43.19 ? 170 VAL A CG2 1 ATOM 785 N N . THR A 1 105 ? 11.169 55.538 49.763 1.00 37.99 ? 171 THR A N 1 ATOM 786 C CA . THR A 1 105 ? 11.231 54.291 49.003 1.00 36.83 ? 171 THR A CA 1 ATOM 787 C C . THR A 1 105 ? 12.213 54.569 47.875 1.00 38.27 ? 171 THR A C 1 ATOM 788 O O . THR A 1 105 ? 11.959 55.444 47.054 1.00 38.34 ? 171 THR A O 1 ATOM 789 C CB . THR A 1 105 ? 9.826 53.840 48.566 1.00 42.76 ? 171 THR A CB 1 ATOM 790 O OG1 . THR A 1 105 ? 9.152 53.355 49.727 1.00 43.71 ? 171 THR A OG1 1 ATOM 791 C CG2 . THR A 1 105 ? 9.859 52.734 47.504 1.00 37.24 ? 171 THR A CG2 1 ATOM 792 N N . GLN A 1 106 ? 13.354 53.868 47.861 1.00 34.54 ? 172 GLN A N 1 ATOM 793 C CA . GLN A 1 106 ? 14.426 54.158 46.909 1.00 33.70 ? 172 GLN A CA 1 ATOM 794 C C . GLN A 1 106 ? 14.946 52.968 46.131 1.00 36.58 ? 172 GLN A C 1 ATOM 795 O O . GLN A 1 106 ? 15.100 51.884 46.695 1.00 37.19 ? 172 GLN A O 1 ATOM 796 C CB . GLN A 1 106 ? 15.586 54.838 47.692 1.00 34.65 ? 172 GLN A CB 1 ATOM 797 C CG . GLN A 1 106 ? 16.751 55.399 46.874 1.00 32.48 ? 172 GLN A CG 1 ATOM 798 C CD . GLN A 1 106 ? 16.311 56.516 45.968 1.00 43.08 ? 172 GLN A CD 1 ATOM 799 O OE1 . GLN A 1 106 ? 15.494 57.358 46.341 1.00 32.96 ? 172 GLN A OE1 1 ATOM 800 N NE2 . GLN A 1 106 ? 16.832 56.529 44.746 1.00 33.94 ? 172 GLN A NE2 1 ATOM 801 N N . MET A 1 107 ? 15.280 53.198 44.845 1.00 30.98 ? 173 MET A N 1 ATOM 802 C CA . MET A 1 107 ? 15.927 52.217 43.980 1.00 30.97 ? 173 MET A CA 1 ATOM 803 C C . MET A 1 107 ? 17.437 52.488 44.127 1.00 34.24 ? 173 MET A C 1 ATOM 804 O O . MET A 1 107 ? 17.907 53.633 44.004 1.00 31.61 ? 173 MET A O 1 ATOM 805 C CB . MET A 1 107 ? 15.453 52.326 42.518 1.00 33.40 ? 173 MET A CB 1 ATOM 806 C CG . MET A 1 107 ? 15.913 51.192 41.625 1.00 37.96 ? 173 MET A CG 1 ATOM 807 S SD . MET A 1 107 ? 15.176 49.563 41.976 1.00 44.29 ? 173 MET A SD 1 ATOM 808 C CE . MET A 1 107 ? 13.478 49.846 41.553 1.00 41.47 ? 173 MET A CE 1 ATOM 809 N N . PHE A 1 108 ? 18.182 51.436 44.460 1.00 29.07 ? 174 PHE A N 1 ATOM 810 C CA . PHE A 1 108 ? 19.608 51.570 44.727 1.00 27.82 ? 174 PHE A CA 1 ATOM 811 C C . PHE A 1 108 ? 20.363 50.394 44.157 1.00 29.76 ? 174 PHE A C 1 ATOM 812 O O . PHE A 1 108 ? 19.767 49.372 43.827 1.00 29.09 ? 174 PHE A O 1 ATOM 813 C CB . PHE A 1 108 ? 19.856 51.741 46.262 1.00 28.58 ? 174 PHE A CB 1 ATOM 814 C CG . PHE A 1 108 ? 19.512 50.533 47.105 1.00 28.41 ? 174 PHE A CG 1 ATOM 815 C CD1 . PHE A 1 108 ? 18.195 50.284 47.495 1.00 29.67 ? 174 PHE A CD1 1 ATOM 816 C CD2 . PHE A 1 108 ? 20.504 49.637 47.508 1.00 28.15 ? 174 PHE A CD2 1 ATOM 817 C CE1 . PHE A 1 108 ? 17.874 49.155 48.264 1.00 29.87 ? 174 PHE A CE1 1 ATOM 818 C CE2 . PHE A 1 108 ? 20.173 48.490 48.247 1.00 30.04 ? 174 PHE A CE2 1 ATOM 819 C CZ . PHE A 1 108 ? 18.865 48.268 48.639 1.00 27.67 ? 174 PHE A CZ 1 ATOM 820 N N . GLY A 1 109 ? 21.667 50.548 44.038 1.00 27.78 ? 175 GLY A N 1 ATOM 821 C CA . GLY A 1 109 ? 22.527 49.473 43.538 1.00 28.02 ? 175 GLY A CA 1 ATOM 822 C C . GLY A 1 109 ? 23.117 48.662 44.676 1.00 31.78 ? 175 GLY A C 1 ATOM 823 O O . GLY A 1 109 ? 23.603 49.230 45.663 1.00 30.48 ? 175 GLY A O 1 ATOM 824 N N . GLU A 1 110 ? 22.997 47.330 44.581 1.00 28.77 ? 176 GLU A N 1 ATOM 825 C CA . GLU A 1 110 ? 23.630 46.349 45.481 1.00 28.41 ? 176 GLU A CA 1 ATOM 826 C C . GLU A 1 110 ? 24.952 45.961 44.737 1.00 31.05 ? 176 GLU A C 1 ATOM 827 O O . GLU A 1 110 ? 24.902 45.325 43.679 1.00 27.53 ? 176 GLU A O 1 ATOM 828 C CB . GLU A 1 110 ? 22.727 45.107 45.650 1.00 29.25 ? 176 GLU A CB 1 ATOM 829 C CG . GLU A 1 110 ? 21.710 45.187 46.780 1.00 30.98 ? 176 GLU A CG 1 ATOM 830 C CD . GLU A 1 110 ? 21.161 43.823 47.171 1.00 45.65 ? 176 GLU A CD 1 ATOM 831 O OE1 . GLU A 1 110 ? 21.938 42.993 47.694 1.00 29.40 ? 176 GLU A OE1 1 ATOM 832 O OE2 . GLU A 1 110 ? 19.961 43.569 46.924 1.00 28.14 ? 176 GLU A OE2 1 ATOM 833 N N . VAL A 1 111 ? 26.117 46.424 45.249 1.00 28.55 ? 177 VAL A N 1 ATOM 834 C CA . VAL A 1 111 ? 27.426 46.228 44.602 1.00 27.35 ? 177 VAL A CA 1 ATOM 835 C C . VAL A 1 111 ? 28.021 44.819 44.890 1.00 32.01 ? 177 VAL A C 1 ATOM 836 O O . VAL A 1 111 ? 28.172 44.399 46.047 1.00 30.88 ? 177 VAL A O 1 ATOM 837 C CB . VAL A 1 111 ? 28.367 47.426 44.948 1.00 29.62 ? 177 VAL A CB 1 ATOM 838 C CG1 . VAL A 1 111 ? 29.850 47.082 44.793 1.00 28.86 ? 177 VAL A CG1 1 ATOM 839 C CG2 . VAL A 1 111 ? 27.996 48.634 44.083 1.00 28.22 ? 177 VAL A CG2 1 ATOM 840 N N . THR A 1 112 ? 28.272 44.063 43.805 1.00 29.23 ? 178 THR A N 1 ATOM 841 C CA . THR A 1 112 ? 28.809 42.701 43.886 1.00 29.15 ? 178 THR A CA 1 ATOM 842 C C . THR A 1 112 ? 30.256 42.651 43.412 1.00 34.55 ? 178 THR A C 1 ATOM 843 O O . THR A 1 112 ? 30.906 41.611 43.545 1.00 35.37 ? 178 THR A O 1 ATOM 844 C CB . THR A 1 112 ? 27.911 41.679 43.151 1.00 33.55 ? 178 THR A CB 1 ATOM 845 O OG1 . THR A 1 112 ? 27.696 42.122 41.816 1.00 35.23 ? 178 THR A OG1 1 ATOM 846 C CG2 . THR A 1 112 ? 26.557 41.443 43.852 1.00 26.80 ? 178 THR A CG2 1 ATOM 847 N N . GLU A 1 113 ? 30.766 43.771 42.852 1.00 29.38 ? 179 GLU A N 1 ATOM 848 C CA . GLU A 1 113 ? 32.141 43.862 42.370 1.00 28.91 ? 179 GLU A CA 1 ATOM 849 C C . GLU A 1 113 ? 32.681 45.199 42.828 1.00 32.32 ? 179 GLU A C 1 ATOM 850 O O . GLU A 1 113 ? 32.280 46.229 42.296 1.00 30.50 ? 179 GLU A O 1 ATOM 851 C CB . GLU A 1 113 ? 32.246 43.660 40.840 1.00 30.18 ? 179 GLU A CB 1 ATOM 852 C CG . GLU A 1 113 ? 31.664 42.335 40.346 1.00 35.81 ? 179 GLU A CG 1 ATOM 853 C CD . GLU A 1 113 ? 31.756 42.074 38.862 1.00 65.81 ? 179 GLU A CD 1 ATOM 854 O OE1 . GLU A 1 113 ? 31.093 42.800 38.091 1.00 65.05 ? 179 GLU A OE1 1 ATOM 855 O OE2 . GLU A 1 113 ? 32.452 41.110 38.469 1.00 76.01 ? 179 GLU A OE2 1 ATOM 856 N N . MET A 1 114 ? 33.564 45.163 43.864 1.00 29.88 ? 180 MET A N 1 ATOM 857 C CA . MET A 1 114 ? 34.138 46.315 44.572 1.00 30.94 ? 180 MET A CA 1 ATOM 858 C C . MET A 1 114 ? 35.688 46.155 44.673 1.00 33.15 ? 180 MET A C 1 ATOM 859 O O . MET A 1 114 ? 36.165 45.497 45.597 1.00 33.20 ? 180 MET A O 1 ATOM 860 C CB . MET A 1 114 ? 33.488 46.358 45.977 1.00 33.96 ? 180 MET A CB 1 ATOM 861 C CG . MET A 1 114 ? 33.632 47.664 46.706 1.00 38.00 ? 180 MET A CG 1 ATOM 862 S SD . MET A 1 114 ? 32.803 47.520 48.305 1.00 41.38 ? 180 MET A SD 1 ATOM 863 C CE . MET A 1 114 ? 32.816 49.104 48.788 1.00 38.66 ? 180 MET A CE 1 ATOM 864 N N . PRO A 1 115 ? 36.469 46.730 43.714 1.00 28.74 ? 181 PRO A N 1 ATOM 865 C CA . PRO A 1 115 ? 37.940 46.573 43.717 1.00 27.92 ? 181 PRO A CA 1 ATOM 866 C C . PRO A 1 115 ? 38.665 47.064 44.970 1.00 35.32 ? 181 PRO A C 1 ATOM 867 O O . PRO A 1 115 ? 38.365 48.148 45.482 1.00 35.90 ? 181 PRO A O 1 ATOM 868 C CB . PRO A 1 115 ? 38.377 47.381 42.487 1.00 28.91 ? 181 PRO A CB 1 ATOM 869 C CG . PRO A 1 115 ? 37.190 47.494 41.638 1.00 32.82 ? 181 PRO A CG 1 ATOM 870 C CD . PRO A 1 115 ? 36.028 47.540 42.561 1.00 28.87 ? 181 PRO A CD 1 ATOM 871 N N . ALA A 1 116 ? 39.634 46.258 45.451 1.00 32.51 ? 182 ALA A N 1 ATOM 872 C CA . ALA A 1 116 ? 40.470 46.529 46.617 1.00 32.70 ? 182 ALA A CA 1 ATOM 873 C C . ALA A 1 116 ? 41.176 47.887 46.492 1.00 36.07 ? 182 ALA A C 1 ATOM 874 O O . ALA A 1 116 ? 41.303 48.625 47.480 1.00 35.33 ? 182 ALA A O 1 ATOM 875 C CB . ALA A 1 116 ? 41.482 45.396 46.798 1.00 33.78 ? 182 ALA A CB 1 ATOM 876 N N . LEU A 1 117 ? 41.590 48.231 45.264 1.00 33.97 ? 183 LEU A N 1 ATOM 877 C CA . LEU A 1 117 ? 42.142 49.541 44.942 1.00 34.22 ? 183 LEU A CA 1 ATOM 878 C C . LEU A 1 117 ? 41.051 50.230 44.128 1.00 37.08 ? 183 LEU A C 1 ATOM 879 O O . LEU A 1 117 ? 40.682 49.702 43.079 1.00 37.46 ? 183 LEU A O 1 ATOM 880 C CB . LEU A 1 117 ? 43.494 49.452 44.197 1.00 34.85 ? 183 LEU A CB 1 ATOM 881 C CG . LEU A 1 117 ? 44.735 49.150 45.091 1.00 40.86 ? 183 LEU A CG 1 ATOM 882 C CD1 . LEU A 1 117 ? 44.704 47.742 45.621 1.00 42.08 ? 183 LEU A CD1 1 ATOM 883 C CD2 . LEU A 1 117 ? 46.033 49.311 44.317 1.00 42.46 ? 183 LEU A CD2 1 ATOM 884 N N . PRO A 1 118 ? 40.362 51.257 44.673 1.00 31.98 ? 184 PRO A N 1 ATOM 885 C CA . PRO A 1 118 ? 40.662 51.999 45.911 1.00 31.52 ? 184 PRO A CA 1 ATOM 886 C C . PRO A 1 118 ? 39.838 51.677 47.171 1.00 34.09 ? 184 PRO A C 1 ATOM 887 O O . PRO A 1 118 ? 40.167 52.201 48.231 1.00 32.34 ? 184 PRO A O 1 ATOM 888 C CB . PRO A 1 118 ? 40.346 53.441 45.488 1.00 32.69 ? 184 PRO A CB 1 ATOM 889 C CG . PRO A 1 118 ? 39.107 53.278 44.624 1.00 37.35 ? 184 PRO A CG 1 ATOM 890 C CD . PRO A 1 118 ? 39.306 51.946 43.891 1.00 33.62 ? 184 PRO A CD 1 ATOM 891 N N . PHE A 1 119 ? 38.772 50.861 47.060 1.00 29.75 ? 185 PHE A N 1 ATOM 892 C CA . PHE A 1 119 ? 37.768 50.653 48.102 1.00 28.82 ? 185 PHE A CA 1 ATOM 893 C C . PHE A 1 119 ? 38.278 50.045 49.429 1.00 33.32 ? 185 PHE A C 1 ATOM 894 O O . PHE A 1 119 ? 37.557 50.159 50.413 1.00 33.28 ? 185 PHE A O 1 ATOM 895 C CB . PHE A 1 119 ? 36.547 49.900 47.544 1.00 29.75 ? 185 PHE A CB 1 ATOM 896 C CG . PHE A 1 119 ? 35.867 50.781 46.506 1.00 29.84 ? 185 PHE A CG 1 ATOM 897 C CD1 . PHE A 1 119 ? 35.180 51.931 46.888 1.00 29.88 ? 185 PHE A CD1 1 ATOM 898 C CD2 . PHE A 1 119 ? 36.021 50.529 45.146 1.00 30.40 ? 185 PHE A CD2 1 ATOM 899 C CE1 . PHE A 1 119 ? 34.618 52.786 45.933 1.00 31.04 ? 185 PHE A CE1 1 ATOM 900 C CE2 . PHE A 1 119 ? 35.469 51.391 44.192 1.00 33.16 ? 185 PHE A CE2 1 ATOM 901 C CZ . PHE A 1 119 ? 34.763 52.514 44.590 1.00 30.63 ? 185 PHE A CZ 1 ATOM 902 N N . MET A 1 120 ? 39.522 49.517 49.500 1.00 29.17 ? 186 MET A N 1 ATOM 903 C CA . MET A 1 120 ? 40.108 49.069 50.774 1.00 26.77 ? 186 MET A CA 1 ATOM 904 C C . MET A 1 120 ? 40.576 50.322 51.584 1.00 29.52 ? 186 MET A C 1 ATOM 905 O O . MET A 1 120 ? 40.817 50.217 52.785 1.00 27.95 ? 186 MET A O 1 ATOM 906 C CB . MET A 1 120 ? 41.282 48.088 50.563 1.00 27.85 ? 186 MET A CB 1 ATOM 907 C CG . MET A 1 120 ? 40.860 46.662 50.425 1.00 30.87 ? 186 MET A CG 1 ATOM 908 S SD . MET A 1 120 ? 39.881 45.962 51.786 1.00 34.43 ? 186 MET A SD 1 ATOM 909 C CE . MET A 1 120 ? 41.218 45.623 53.022 1.00 29.94 ? 186 MET A CE 1 ATOM 910 N N . LEU A 1 121 ? 40.701 51.491 50.920 1.00 27.35 ? 187 LEU A N 1 ATOM 911 C CA . LEU A 1 121 ? 41.084 52.773 51.532 1.00 28.39 ? 187 LEU A CA 1 ATOM 912 C C . LEU A 1 121 ? 39.853 53.587 51.949 1.00 32.30 ? 187 LEU A C 1 ATOM 913 O O . LEU A 1 121 ? 39.979 54.623 52.596 1.00 32.22 ? 187 LEU A O 1 ATOM 914 C CB . LEU A 1 121 ? 41.973 53.598 50.586 1.00 29.22 ? 187 LEU A CB 1 ATOM 915 C CG . LEU A 1 121 ? 43.389 53.048 50.308 1.00 35.19 ? 187 LEU A CG 1 ATOM 916 C CD1 . LEU A 1 121 ? 44.084 53.866 49.241 1.00 35.53 ? 187 LEU A CD1 1 ATOM 917 C CD2 . LEU A 1 121 ? 44.267 53.062 51.569 1.00 38.12 ? 187 LEU A CD2 1 ATOM 918 N N . ALA A 1 122 ? 38.656 53.102 51.598 1.00 27.60 ? 188 ALA A N 1 ATOM 919 C CA . ALA A 1 122 ? 37.398 53.760 51.944 1.00 26.72 ? 188 ALA A CA 1 ATOM 920 C C . ALA A 1 122 ? 36.941 53.430 53.375 1.00 29.12 ? 188 ALA A C 1 ATOM 921 O O . ALA A 1 122 ? 36.872 52.261 53.755 1.00 28.28 ? 188 ALA A O 1 ATOM 922 C CB . ALA A 1 122 ? 36.318 53.366 50.941 1.00 27.20 ? 188 ALA A CB 1 ATOM 923 N N . GLU A 1 123 ? 36.654 54.467 54.170 1.00 26.64 ? 189 GLU A N 1 ATOM 924 C CA . GLU A 1 123 ? 36.126 54.355 55.532 1.00 27.35 ? 189 GLU A CA 1 ATOM 925 C C . GLU A 1 123 ? 34.597 54.139 55.444 1.00 31.50 ? 189 GLU A C 1 ATOM 926 O O . GLU A 1 123 ? 34.010 53.492 56.302 1.00 33.24 ? 189 GLU A O 1 ATOM 927 C CB . GLU A 1 123 ? 36.390 55.651 56.326 1.00 29.14 ? 189 GLU A CB 1 ATOM 928 C CG . GLU A 1 123 ? 37.207 55.490 57.593 1.00 42.46 ? 189 GLU A CG 1 ATOM 929 C CD . GLU A 1 123 ? 36.906 54.370 58.565 1.00 61.83 ? 189 GLU A CD 1 ATOM 930 O OE1 . GLU A 1 123 ? 35.718 54.156 58.900 1.00 59.49 ? 189 GLU A OE1 1 ATOM 931 O OE2 . GLU A 1 123 ? 37.881 53.760 59.057 1.00 63.48 ? 189 GLU A OE2 1 ATOM 932 N N . PHE A 1 124 ? 33.974 54.716 54.421 1.00 26.34 ? 190 PHE A N 1 ATOM 933 C CA . PHE A 1 124 ? 32.567 54.628 54.129 1.00 26.65 ? 190 PHE A CA 1 ATOM 934 C C . PHE A 1 124 ? 32.301 53.290 53.450 1.00 31.47 ? 190 PHE A C 1 ATOM 935 O O . PHE A 1 124 ? 33.233 52.659 52.927 1.00 30.60 ? 190 PHE A O 1 ATOM 936 C CB . PHE A 1 124 ? 32.148 55.817 53.209 1.00 28.45 ? 190 PHE A CB 1 ATOM 937 C CG . PHE A 1 124 ? 32.860 55.895 51.870 1.00 29.09 ? 190 PHE A CG 1 ATOM 938 C CD1 . PHE A 1 124 ? 32.380 55.188 50.758 1.00 29.87 ? 190 PHE A CD1 1 ATOM 939 C CD2 . PHE A 1 124 ? 34.011 56.670 51.713 1.00 30.16 ? 190 PHE A CD2 1 ATOM 940 C CE1 . PHE A 1 124 ? 33.046 55.247 49.520 1.00 30.05 ? 190 PHE A CE1 1 ATOM 941 C CE2 . PHE A 1 124 ? 34.672 56.739 50.475 1.00 31.77 ? 190 PHE A CE2 1 ATOM 942 C CZ . PHE A 1 124 ? 34.181 56.034 49.385 1.00 29.96 ? 190 PHE A CZ 1 ATOM 943 N N . ASP A 1 125 ? 31.017 52.895 53.397 1.00 27.93 ? 191 ASP A N 1 ATOM 944 C CA . ASP A 1 125 ? 30.552 51.675 52.747 1.00 26.53 ? 191 ASP A CA 1 ATOM 945 C C . ASP A 1 125 ? 30.057 51.958 51.329 1.00 30.45 ? 191 ASP A C 1 ATOM 946 O O . ASP A 1 125 ? 30.431 51.249 50.389 1.00 30.26 ? 191 ASP A O 1 ATOM 947 C CB . ASP A 1 125 ? 29.440 50.998 53.584 1.00 28.08 ? 191 ASP A CB 1 ATOM 948 C CG . ASP A 1 125 ? 29.846 50.664 55.011 1.00 31.89 ? 191 ASP A CG 1 ATOM 949 O OD1 . ASP A 1 125 ? 30.790 49.850 55.189 1.00 34.36 ? 191 ASP A OD1 1 ATOM 950 O OD2 . ASP A 1 125 ? 29.210 51.194 55.948 1.00 28.15 ? 191 ASP A OD2 1 ATOM 951 N N . GLY A 1 126 ? 29.241 52.999 51.182 1.00 26.97 ? 192 GLY A N 1 ATOM 952 C CA . GLY A 1 126 ? 28.637 53.335 49.904 1.00 26.36 ? 192 GLY A CA 1 ATOM 953 C C . GLY A 1 126 ? 28.501 54.794 49.590 1.00 29.80 ? 192 GLY A C 1 ATOM 954 O O . GLY A 1 126 ? 29.152 55.637 50.201 1.00 29.24 ? 192 GLY A O 1 ATOM 955 N N . VAL A 1 127 ? 27.679 55.090 48.576 1.00 28.25 ? 193 VAL A N 1 ATOM 956 C CA . VAL A 1 127 ? 27.525 56.455 48.058 1.00 28.12 ? 193 VAL A CA 1 ATOM 957 C C . VAL A 1 127 ? 26.051 56.813 47.872 1.00 32.13 ? 193 VAL A C 1 ATOM 958 O O . VAL A 1 127 ? 25.279 55.990 47.399 1.00 31.94 ? 193 VAL A O 1 ATOM 959 C CB . VAL A 1 127 ? 28.342 56.637 46.728 1.00 30.42 ? 193 VAL A CB 1 ATOM 960 C CG1 . VAL A 1 127 ? 28.138 58.031 46.107 1.00 29.73 ? 193 VAL A CG1 1 ATOM 961 C CG2 . VAL A 1 127 ? 29.836 56.355 46.935 1.00 29.26 ? 193 VAL A CG2 1 ATOM 962 N N . VAL A 1 128 ? 25.684 58.039 48.251 1.00 29.05 ? 194 VAL A N 1 ATOM 963 C CA . VAL A 1 128 ? 24.363 58.636 48.055 1.00 28.51 ? 194 VAL A CA 1 ATOM 964 C C . VAL A 1 128 ? 24.576 59.770 47.042 1.00 31.10 ? 194 VAL A C 1 ATOM 965 O O . VAL A 1 128 ? 25.076 60.837 47.400 1.00 29.40 ? 194 VAL A O 1 ATOM 966 C CB . VAL A 1 128 ? 23.691 59.119 49.374 1.00 32.17 ? 194 VAL A CB 1 ATOM 967 C CG1 . VAL A 1 128 ? 22.476 60.004 49.086 1.00 31.51 ? 194 VAL A CG1 1 ATOM 968 C CG2 . VAL A 1 128 ? 23.288 57.926 50.236 1.00 31.76 ? 194 VAL A CG2 1 ATOM 969 N N . GLY A 1 129 ? 24.311 59.470 45.771 1.00 27.60 ? 195 GLY A N 1 ATOM 970 C CA . GLY A 1 129 ? 24.454 60.442 44.701 1.00 28.02 ? 195 GLY A CA 1 ATOM 971 C C . GLY A 1 129 ? 23.454 61.573 44.844 1.00 30.34 ? 195 GLY A C 1 ATOM 972 O O . GLY A 1 129 ? 22.247 61.320 44.873 1.00 27.61 ? 195 GLY A O 1 ATOM 973 N N . MET A 1 130 ? 23.967 62.817 44.981 1.00 26.29 ? 196 MET A N 1 ATOM 974 C CA . MET A 1 130 ? 23.192 64.049 45.153 1.00 26.56 ? 196 MET A CA 1 ATOM 975 C C . MET A 1 130 ? 23.034 64.825 43.828 1.00 32.55 ? 196 MET A C 1 ATOM 976 O O . MET A 1 130 ? 22.448 65.908 43.818 1.00 33.31 ? 196 MET A O 1 ATOM 977 C CB . MET A 1 130 ? 23.799 64.958 46.256 1.00 28.66 ? 196 MET A CB 1 ATOM 978 C CG . MET A 1 130 ? 23.754 64.383 47.665 1.00 31.94 ? 196 MET A CG 1 ATOM 979 S SD . MET A 1 130 ? 22.131 63.929 48.278 1.00 36.96 ? 196 MET A SD 1 ATOM 980 C CE . MET A 1 130 ? 21.430 65.510 48.651 1.00 33.14 ? 196 MET A CE 1 ATOM 981 N N . GLY A 1 131 ? 23.515 64.240 42.732 1.00 29.60 ? 197 GLY A N 1 ATOM 982 C CA . GLY A 1 131 ? 23.419 64.795 41.390 1.00 29.91 ? 197 GLY A CA 1 ATOM 983 C C . GLY A 1 131 ? 22.034 64.647 40.773 1.00 36.99 ? 197 GLY A C 1 ATOM 984 O O . GLY A 1 131 ? 21.110 64.116 41.404 1.00 37.20 ? 197 GLY A O 1 ATOM 985 N N . PHE A 1 132 ? 21.881 65.120 39.523 1.00 34.36 ? 198 PHE A N 1 ATOM 986 C CA . PHE A 1 132 ? 20.604 65.098 38.799 1.00 34.70 ? 198 PHE A CA 1 ATOM 987 C C . PHE A 1 132 ? 20.324 63.786 38.067 1.00 38.42 ? 198 PHE A C 1 ATOM 988 O O . PHE A 1 132 ? 21.257 63.060 37.723 1.00 37.78 ? 198 PHE A O 1 ATOM 989 C CB . PHE A 1 132 ? 20.571 66.243 37.773 1.00 36.53 ? 198 PHE A CB 1 ATOM 990 C CG . PHE A 1 132 ? 20.670 67.661 38.289 1.00 36.63 ? 198 PHE A CG 1 ATOM 991 C CD1 . PHE A 1 132 ? 21.890 68.185 38.706 1.00 38.32 ? 198 PHE A CD1 1 ATOM 992 C CD2 . PHE A 1 132 ? 19.566 68.498 38.276 1.00 37.41 ? 198 PHE A CD2 1 ATOM 993 C CE1 . PHE A 1 132 ? 21.995 69.513 39.125 1.00 38.95 ? 198 PHE A CE1 1 ATOM 994 C CE2 . PHE A 1 132 ? 19.670 69.824 38.707 1.00 40.18 ? 198 PHE A CE2 1 ATOM 995 C CZ . PHE A 1 132 ? 20.880 70.316 39.145 1.00 38.50 ? 198 PHE A CZ 1 ATOM 996 N N . ILE A 1 133 ? 19.036 63.527 37.762 1.00 35.83 ? 199 ILE A N 1 ATOM 997 C CA . ILE A 1 133 ? 18.550 62.360 37.009 1.00 36.86 ? 199 ILE A CA 1 ATOM 998 C C . ILE A 1 133 ? 19.241 62.230 35.643 1.00 42.81 ? 199 ILE A C 1 ATOM 999 O O . ILE A 1 133 ? 19.488 61.105 35.205 1.00 43.32 ? 199 ILE A O 1 ATOM 1000 C CB . ILE A 1 133 ? 16.991 62.341 36.906 1.00 41.11 ? 199 ILE A CB 1 ATOM 1001 C CG1 . ILE A 1 133 ? 16.466 60.933 36.470 1.00 41.61 ? 199 ILE A CG1 1 ATOM 1002 C CG2 . ILE A 1 133 ? 16.435 63.491 36.025 1.00 40.65 ? 199 ILE A CG2 1 ATOM 1003 C CD1 . ILE A 1 133 ? 15.020 60.599 36.892 1.00 43.34 ? 199 ILE A CD1 1 ATOM 1004 N N . GLU A 1 134 ? 19.611 63.378 35.004 1.00 39.63 ? 200 GLU A N 1 ATOM 1005 C CA . GLU A 1 134 ? 20.299 63.417 33.708 1.00 39.78 ? 200 GLU A CA 1 ATOM 1006 C C . GLU A 1 134 ? 21.598 62.603 33.716 1.00 45.78 ? 200 GLU A C 1 ATOM 1007 O O . GLU A 1 134 ? 21.964 62.059 32.678 1.00 46.98 ? 200 GLU A O 1 ATOM 1008 C CB . GLU A 1 134 ? 20.575 64.873 33.270 1.00 41.26 ? 200 GLU A CB 1 ATOM 1009 C CG . GLU A 1 134 ? 19.344 65.685 32.861 1.00 49.47 ? 200 GLU A CG 1 ATOM 1010 C CD . GLU A 1 134 ? 18.579 66.428 33.948 1.00 65.19 ? 200 GLU A CD 1 ATOM 1011 O OE1 . GLU A 1 134 ? 18.653 66.013 35.123 1.00 55.98 ? 200 GLU A OE1 1 ATOM 1012 O OE2 . GLU A 1 134 ? 17.851 67.391 33.615 1.00 62.62 ? 200 GLU A OE2 1 ATOM 1013 N N . GLN A 1 135 ? 22.289 62.507 34.886 1.00 41.83 ? 201 GLN A N 1 ATOM 1014 C CA . GLN A 1 135 ? 23.551 61.760 35.019 1.00 40.91 ? 201 GLN A CA 1 ATOM 1015 C C . GLN A 1 135 ? 23.404 60.411 35.743 1.00 43.23 ? 201 GLN A C 1 ATOM 1016 O O . GLN A 1 135 ? 24.412 59.731 35.960 1.00 42.38 ? 201 GLN A O 1 ATOM 1017 C CB . GLN A 1 135 ? 24.630 62.613 35.698 1.00 42.59 ? 201 GLN A CB 1 ATOM 1018 C CG . GLN A 1 135 ? 24.821 63.995 35.093 1.00 56.90 ? 201 GLN A CG 1 ATOM 1019 C CD . GLN A 1 135 ? 25.750 64.014 33.919 1.00 80.06 ? 201 GLN A CD 1 ATOM 1020 O OE1 . GLN A 1 135 ? 25.440 63.524 32.829 1.00 74.91 ? 201 GLN A OE1 1 ATOM 1021 N NE2 . GLN A 1 135 ? 26.900 64.624 34.117 1.00 78.04 ? 201 GLN A NE2 1 ATOM 1022 N N . ALA A 1 136 ? 22.153 60.022 36.100 1.00 38.71 ? 202 ALA A N 1 ATOM 1023 C CA . ALA A 1 136 ? 21.844 58.762 36.767 1.00 37.50 ? 202 ALA A CA 1 ATOM 1024 C C . ALA A 1 136 ? 21.967 57.576 35.805 1.00 42.16 ? 202 ALA A C 1 ATOM 1025 O O . ALA A 1 136 ? 21.328 57.563 34.744 1.00 41.61 ? 202 ALA A O 1 ATOM 1026 C CB . ALA A 1 136 ? 20.458 58.817 37.376 1.00 37.60 ? 202 ALA A CB 1 ATOM 1027 N N . ILE A 1 137 ? 22.845 56.606 36.157 1.00 38.95 ? 203 ILE A N 1 ATOM 1028 C CA . ILE A 1 137 ? 23.076 55.385 35.372 1.00 38.35 ? 203 ILE A CA 1 ATOM 1029 C C . ILE A 1 137 ? 21.832 54.491 35.528 1.00 42.01 ? 203 ILE A C 1 ATOM 1030 O O . ILE A 1 137 ? 21.307 54.351 36.641 1.00 39.81 ? 203 ILE A O 1 ATOM 1031 C CB . ILE A 1 137 ? 24.419 54.664 35.770 1.00 40.66 ? 203 ILE A CB 1 ATOM 1032 C CG1 . ILE A 1 137 ? 25.654 55.615 35.708 1.00 39.72 ? 203 ILE A CG1 1 ATOM 1033 C CG2 . ILE A 1 137 ? 24.663 53.370 34.966 1.00 40.56 ? 203 ILE A CG2 1 ATOM 1034 C CD1 . ILE A 1 137 ? 26.016 56.249 34.292 1.00 39.05 ? 203 ILE A CD1 1 ATOM 1035 N N . GLY A 1 138 ? 21.342 53.962 34.400 1.00 39.61 ? 204 GLY A N 1 ATOM 1036 C CA . GLY A 1 138 ? 20.137 53.136 34.350 1.00 39.26 ? 204 GLY A CA 1 ATOM 1037 C C . GLY A 1 138 ? 18.869 53.954 34.501 1.00 45.92 ? 204 GLY A C 1 ATOM 1038 O O . GLY A 1 138 ? 17.785 53.391 34.699 1.00 46.43 ? 204 GLY A O 1 ATOM 1039 N N . ARG A 1 139 ? 19.004 55.308 34.397 1.00 43.94 ? 205 ARG A N 1 ATOM 1040 C CA . ARG A 1 139 ? 17.937 56.309 34.508 1.00 44.97 ? 205 ARG A CA 1 ATOM 1041 C C . ARG A 1 139 ? 17.090 56.091 35.793 1.00 49.63 ? 205 ARG A C 1 ATOM 1042 O O . ARG A 1 139 ? 15.856 56.179 35.769 1.00 50.93 ? 205 ARG A O 1 ATOM 1043 C CB . ARG A 1 139 ? 17.072 56.364 33.218 1.00 47.25 ? 205 ARG A CB 1 ATOM 1044 C CG . ARG A 1 139 ? 17.867 56.526 31.922 1.00 55.06 ? 205 ARG A CG 1 ATOM 1045 C CD . ARG A 1 139 ? 17.056 56.203 30.662 1.00 74.52 ? 205 ARG A CD 1 ATOM 1046 N NE . ARG A 1 139 ? 16.308 54.935 30.729 1.00 82.32 ? 205 ARG A NE 1 ATOM 1047 C CZ . ARG A 1 139 ? 16.828 53.725 30.521 1.00 98.23 ? 205 ARG A CZ 1 ATOM 1048 N NH1 . ARG A 1 139 ? 18.121 53.585 30.244 1.00 84.87 ? 205 ARG A NH1 1 ATOM 1049 N NH2 . ARG A 1 139 ? 16.061 52.646 30.601 1.00 86.83 ? 205 ARG A NH2 1 ATOM 1050 N N . VAL A 1 140 ? 17.781 55.784 36.913 1.00 43.33 ? 206 VAL A N 1 ATOM 1051 C CA . VAL A 1 140 ? 17.176 55.548 38.224 1.00 41.53 ? 206 VAL A CA 1 ATOM 1052 C C . VAL A 1 140 ? 16.917 56.914 38.879 1.00 43.14 ? 206 VAL A C 1 ATOM 1053 O O . VAL A 1 140 ? 17.813 57.762 38.894 1.00 42.89 ? 206 VAL A O 1 ATOM 1054 C CB . VAL A 1 140 ? 18.113 54.650 39.096 1.00 44.22 ? 206 VAL A CB 1 ATOM 1055 C CG1 . VAL A 1 140 ? 17.536 54.425 40.480 1.00 43.59 ? 206 VAL A CG1 1 ATOM 1056 C CG2 . VAL A 1 140 ? 18.399 53.322 38.416 1.00 43.64 ? 206 VAL A CG2 1 ATOM 1057 N N . THR A 1 141 ? 15.719 57.125 39.424 1.00 39.17 ? 207 THR A N 1 ATOM 1058 C CA . THR A 1 141 ? 15.401 58.392 40.089 1.00 39.34 ? 207 THR A CA 1 ATOM 1059 C C . THR A 1 141 ? 16.315 58.653 41.319 1.00 44.81 ? 207 THR A C 1 ATOM 1060 O O . THR A 1 141 ? 16.315 57.854 42.264 1.00 45.23 ? 207 THR A O 1 ATOM 1061 C CB . THR A 1 141 ? 13.917 58.475 40.461 1.00 42.76 ? 207 THR A CB 1 ATOM 1062 O OG1 . THR A 1 141 ? 13.140 58.077 39.342 1.00 42.18 ? 207 THR A OG1 1 ATOM 1063 C CG2 . THR A 1 141 ? 13.507 59.885 40.879 1.00 42.94 ? 207 THR A CG2 1 ATOM 1064 N N . PRO A 1 142 ? 17.076 59.771 41.335 1.00 41.52 ? 208 PRO A N 1 ATOM 1065 C CA . PRO A 1 142 ? 17.924 60.066 42.502 1.00 40.87 ? 208 PRO A CA 1 ATOM 1066 C C . PRO A 1 142 ? 17.108 60.295 43.769 1.00 42.30 ? 208 PRO A C 1 ATOM 1067 O O . PRO A 1 142 ? 15.951 60.723 43.685 1.00 42.20 ? 208 PRO A O 1 ATOM 1068 C CB . PRO A 1 142 ? 18.683 61.329 42.076 1.00 42.17 ? 208 PRO A CB 1 ATOM 1069 C CG . PRO A 1 142 ? 18.607 61.337 40.582 1.00 46.08 ? 208 PRO A CG 1 ATOM 1070 C CD . PRO A 1 142 ? 17.234 60.814 40.306 1.00 42.76 ? 208 PRO A CD 1 ATOM 1071 N N . ILE A 1 143 ? 17.709 59.992 44.935 1.00 35.96 ? 209 ILE A N 1 ATOM 1072 C CA . ILE A 1 143 ? 17.076 60.106 46.256 1.00 34.26 ? 209 ILE A CA 1 ATOM 1073 C C . ILE A 1 143 ? 16.494 61.505 46.541 1.00 37.71 ? 209 ILE A C 1 ATOM 1074 O O . ILE A 1 143 ? 15.441 61.567 47.178 1.00 37.71 ? 209 ILE A O 1 ATOM 1075 C CB . ILE A 1 143 ? 18.030 59.628 47.394 1.00 35.94 ? 209 ILE A CB 1 ATOM 1076 C CG1 . ILE A 1 143 ? 17.248 59.201 48.650 1.00 36.01 ? 209 ILE A CG1 1 ATOM 1077 C CG2 . ILE A 1 143 ? 19.116 60.666 47.701 1.00 35.32 ? 209 ILE A CG2 1 ATOM 1078 C CD1 . ILE A 1 143 ? 18.023 58.330 49.719 1.00 34.90 ? 209 ILE A CD1 1 ATOM 1079 N N . PHE A 1 144 ? 17.175 62.611 46.114 1.00 34.33 ? 210 PHE A N 1 ATOM 1080 C CA . PHE A 1 144 ? 16.672 63.959 46.399 1.00 34.39 ? 210 PHE A CA 1 ATOM 1081 C C . PHE A 1 144 ? 15.367 64.236 45.651 1.00 39.07 ? 210 PHE A C 1 ATOM 1082 O O . PHE A 1 144 ? 14.437 64.791 46.241 1.00 38.50 ? 210 PHE A O 1 ATOM 1083 C CB . PHE A 1 144 ? 17.723 65.072 46.203 1.00 35.84 ? 210 PHE A CB 1 ATOM 1084 C CG . PHE A 1 144 ? 17.355 66.369 46.903 1.00 36.74 ? 210 PHE A CG 1 ATOM 1085 C CD1 . PHE A 1 144 ? 17.376 66.463 48.292 1.00 38.33 ? 210 PHE A CD1 1 ATOM 1086 C CD2 . PHE A 1 144 ? 16.968 67.491 46.174 1.00 38.71 ? 210 PHE A CD2 1 ATOM 1087 C CE1 . PHE A 1 144 ? 17.018 67.661 48.937 1.00 39.22 ? 210 PHE A CE1 1 ATOM 1088 C CE2 . PHE A 1 144 ? 16.623 68.689 46.821 1.00 40.13 ? 210 PHE A CE2 1 ATOM 1089 C CZ . PHE A 1 144 ? 16.641 68.761 48.193 1.00 37.98 ? 210 PHE A CZ 1 ATOM 1090 N N . ASP A 1 145 ? 15.262 63.755 44.399 1.00 36.98 ? 211 ASP A N 1 ATOM 1091 C CA . ASP A 1 145 ? 14.038 63.863 43.593 1.00 37.36 ? 211 ASP A CA 1 ATOM 1092 C C . ASP A 1 145 ? 12.886 63.125 44.293 1.00 43.15 ? 211 ASP A C 1 ATOM 1093 O O . ASP A 1 145 ? 11.792 63.676 44.390 1.00 45.85 ? 211 ASP A O 1 ATOM 1094 C CB . ASP A 1 145 ? 14.252 63.352 42.164 1.00 39.50 ? 211 ASP A CB 1 ATOM 1095 C CG . ASP A 1 145 ? 15.301 64.110 41.364 1.00 53.25 ? 211 ASP A CG 1 ATOM 1096 O OD1 . ASP A 1 145 ? 16.470 64.146 41.795 1.00 59.02 ? 211 ASP A OD1 1 ATOM 1097 O OD2 . ASP A 1 145 ? 14.980 64.579 40.273 1.00 61.30 ? 211 ASP A OD2 1 ATOM 1098 N N . ASN A 1 146 ? 13.147 61.943 44.867 1.00 38.90 ? 212 ASN A N 1 ATOM 1099 C CA . ASN A 1 146 ? 12.108 61.195 45.585 1.00 39.03 ? 212 ASN A CA 1 ATOM 1100 C C . ASN A 1 146 ? 11.680 61.890 46.881 1.00 43.80 ? 212 ASN A C 1 ATOM 1101 O O . ASN A 1 146 ? 10.502 61.845 47.220 1.00 43.01 ? 212 ASN A O 1 ATOM 1102 C CB . ASN A 1 146 ? 12.501 59.727 45.818 1.00 37.67 ? 212 ASN A CB 1 ATOM 1103 C CG . ASN A 1 146 ? 12.602 58.877 44.572 1.00 44.06 ? 212 ASN A CG 1 ATOM 1104 O OD1 . ASN A 1 146 ? 11.894 59.064 43.600 1.00 41.18 ? 212 ASN A OD1 1 ATOM 1105 N ND2 . ASN A 1 146 ? 13.458 57.880 44.589 1.00 34.36 ? 212 ASN A ND2 1 ATOM 1106 N N . ILE A 1 147 ? 12.618 62.585 47.561 1.00 42.16 ? 213 ILE A N 1 ATOM 1107 C CA . ILE A 1 147 ? 12.338 63.347 48.787 1.00 42.87 ? 213 ILE A CA 1 ATOM 1108 C C . ILE A 1 147 ? 11.500 64.604 48.419 1.00 50.96 ? 213 ILE A C 1 ATOM 1109 O O . ILE A 1 147 ? 10.503 64.897 49.086 1.00 51.51 ? 213 ILE A O 1 ATOM 1110 C CB . ILE A 1 147 ? 13.629 63.667 49.599 1.00 45.30 ? 213 ILE A CB 1 ATOM 1111 C CG1 . ILE A 1 147 ? 14.276 62.358 50.158 1.00 45.06 ? 213 ILE A CG1 1 ATOM 1112 C CG2 . ILE A 1 147 ? 13.326 64.652 50.728 1.00 46.11 ? 213 ILE A CG2 1 ATOM 1113 C CD1 . ILE A 1 147 ? 15.723 62.506 50.755 1.00 46.04 ? 213 ILE A CD1 1 ATOM 1114 N N . ILE A 1 148 ? 11.871 65.289 47.316 1.00 48.12 ? 214 ILE A N 1 ATOM 1115 C CA . ILE A 1 148 ? 11.127 66.433 46.795 1.00 47.89 ? 214 ILE A CA 1 ATOM 1116 C C . ILE A 1 148 ? 9.656 66.028 46.514 1.00 50.43 ? 214 ILE A C 1 ATOM 1117 O O . ILE A 1 148 ? 8.746 66.737 46.942 1.00 51.06 ? 214 ILE A O 1 ATOM 1118 C CB . ILE A 1 148 ? 11.851 67.059 45.555 1.00 50.74 ? 214 ILE A CB 1 ATOM 1119 C CG1 . ILE A 1 148 ? 13.138 67.825 45.950 1.00 51.17 ? 214 ILE A CG1 1 ATOM 1120 C CG2 . ILE A 1 148 ? 10.916 67.932 44.691 1.00 50.27 ? 214 ILE A CG2 1 ATOM 1121 C CD1 . ILE A 1 148 ? 13.042 68.813 47.195 1.00 61.11 ? 214 ILE A CD1 1 ATOM 1122 N N . SER A 1 149 ? 9.438 64.858 45.883 1.00 44.65 ? 215 SER A N 1 ATOM 1123 C CA . SER A 1 149 ? 8.105 64.332 45.567 1.00 44.38 ? 215 SER A CA 1 ATOM 1124 C C . SER A 1 149 ? 7.190 64.192 46.778 1.00 48.77 ? 215 SER A C 1 ATOM 1125 O O . SER A 1 149 ? 5.975 64.230 46.617 1.00 48.59 ? 215 SER A O 1 ATOM 1126 C CB . SER A 1 149 ? 8.205 63.005 44.820 1.00 46.94 ? 215 SER A CB 1 ATOM 1127 O OG . SER A 1 149 ? 8.774 63.237 43.545 1.00 55.12 ? 215 SER A OG 1 ATOM 1128 N N . GLN A 1 150 ? 7.763 64.040 47.991 1.00 45.62 ? 216 GLN A N 1 ATOM 1129 C CA . GLN A 1 150 ? 6.983 63.925 49.231 1.00 45.17 ? 216 GLN A CA 1 ATOM 1130 C C . GLN A 1 150 ? 6.352 65.259 49.643 1.00 47.60 ? 216 GLN A C 1 ATOM 1131 O O . GLN A 1 150 ? 5.432 65.246 50.461 1.00 47.85 ? 216 GLN A O 1 ATOM 1132 C CB . GLN A 1 150 ? 7.841 63.402 50.396 1.00 46.66 ? 216 GLN A CB 1 ATOM 1133 C CG . GLN A 1 150 ? 8.513 62.056 50.138 1.00 55.50 ? 216 GLN A CG 1 ATOM 1134 C CD . GLN A 1 150 ? 9.208 61.521 51.367 1.00 62.31 ? 216 GLN A CD 1 ATOM 1135 O OE1 . GLN A 1 150 ? 9.471 62.232 52.344 1.00 60.51 ? 216 GLN A OE1 1 ATOM 1136 N NE2 . GLN A 1 150 ? 9.512 60.242 51.347 1.00 52.68 ? 216 GLN A NE2 1 ATOM 1137 N N . GLY A 1 151 ? 6.883 66.376 49.127 1.00 42.34 ? 217 GLY A N 1 ATOM 1138 C CA . GLY A 1 151 ? 6.429 67.725 49.439 1.00 42.47 ? 217 GLY A CA 1 ATOM 1139 C C . GLY A 1 151 ? 6.479 68.074 50.916 1.00 49.77 ? 217 GLY A C 1 ATOM 1140 O O . GLY A 1 151 ? 5.540 68.684 51.439 1.00 50.66 ? 217 GLY A O 1 ATOM 1141 N N . VAL A 1 152 ? 7.568 67.664 51.605 1.00 46.79 ? 218 VAL A N 1 ATOM 1142 C CA . VAL A 1 152 ? 7.765 67.904 53.038 1.00 46.42 ? 218 VAL A CA 1 ATOM 1143 C C . VAL A 1 152 ? 8.860 68.958 53.306 1.00 50.17 ? 218 VAL A C 1 ATOM 1144 O O . VAL A 1 152 ? 8.851 69.559 54.385 1.00 50.63 ? 218 VAL A O 1 ATOM 1145 C CB . VAL A 1 152 ? 7.988 66.600 53.871 1.00 50.37 ? 218 VAL A CB 1 ATOM 1146 C CG1 . VAL A 1 152 ? 6.820 65.634 53.715 1.00 50.56 ? 218 VAL A CG1 1 ATOM 1147 C CG2 . VAL A 1 152 ? 9.313 65.907 53.536 1.00 49.99 ? 218 VAL A CG2 1 ATOM 1148 N N . LEU A 1 153 ? 9.777 69.184 52.339 1.00 45.24 ? 219 LEU A N 1 ATOM 1149 C CA . LEU A 1 153 ? 10.895 70.130 52.488 1.00 45.29 ? 219 LEU A CA 1 ATOM 1150 C C . LEU A 1 153 ? 10.489 71.601 52.367 1.00 49.95 ? 219 LEU A C 1 ATOM 1151 O O . LEU A 1 153 ? 9.703 71.928 51.485 1.00 50.36 ? 219 LEU A O 1 ATOM 1152 C CB . LEU A 1 153 ? 12.055 69.801 51.511 1.00 45.27 ? 219 LEU A CB 1 ATOM 1153 C CG . LEU A 1 153 ? 12.772 68.417 51.684 1.00 49.43 ? 219 LEU A CG 1 ATOM 1154 C CD1 . LEU A 1 153 ? 13.860 68.256 50.686 1.00 49.51 ? 219 LEU A CD1 1 ATOM 1155 C CD2 . LEU A 1 153 ? 13.384 68.243 53.083 1.00 50.06 ? 219 LEU A CD2 1 ATOM 1156 N N . LYS A 1 154 ? 11.053 72.496 53.231 1.00 46.33 ? 220 LYS A N 1 ATOM 1157 C CA . LYS A 1 154 ? 10.778 73.938 53.193 1.00 45.90 ? 220 LYS A CA 1 ATOM 1158 C C . LYS A 1 154 ? 11.176 74.534 51.851 1.00 50.65 ? 220 LYS A C 1 ATOM 1159 O O . LYS A 1 154 ? 10.405 75.291 51.267 1.00 51.00 ? 220 LYS A O 1 ATOM 1160 C CB . LYS A 1 154 ? 11.463 74.677 54.355 1.00 48.15 ? 220 LYS A CB 1 ATOM 1161 N N . GLU A 1 155 ? 12.361 74.150 51.341 1.00 47.35 ? 221 GLU A N 1 ATOM 1162 C CA . GLU A 1 155 ? 12.903 74.599 50.055 1.00 46.29 ? 221 GLU A CA 1 ATOM 1163 C C . GLU A 1 155 ? 13.536 73.419 49.301 1.00 48.42 ? 221 GLU A C 1 ATOM 1164 O O . GLU A 1 155 ? 14.032 72.472 49.906 1.00 46.35 ? 221 GLU A O 1 ATOM 1165 C CB . GLU A 1 155 ? 13.924 75.735 50.217 1.00 47.63 ? 221 GLU A CB 1 ATOM 1166 C CG . GLU A 1 155 ? 13.398 77.009 50.849 1.00 58.88 ? 221 GLU A CG 1 ATOM 1167 C CD . GLU A 1 155 ? 14.487 77.667 51.664 1.00 90.88 ? 221 GLU A CD 1 ATOM 1168 O OE1 . GLU A 1 155 ? 15.400 78.265 51.049 1.00 85.69 ? 221 GLU A OE1 1 ATOM 1169 O OE2 . GLU A 1 155 ? 14.440 77.579 52.915 1.00 92.32 ? 221 GLU A OE2 1 ATOM 1170 N N . ASP A 1 156 ? 13.507 73.477 47.968 1.00 44.45 ? 222 ASP A N 1 ATOM 1171 C CA . ASP A 1 156 ? 14.041 72.467 47.068 1.00 43.00 ? 222 ASP A CA 1 ATOM 1172 C C . ASP A 1 156 ? 15.582 72.736 46.934 1.00 43.30 ? 222 ASP A C 1 ATOM 1173 O O . ASP A 1 156 ? 16.102 73.013 45.849 1.00 42.71 ? 222 ASP A O 1 ATOM 1174 C CB . ASP A 1 156 ? 13.229 72.564 45.747 1.00 45.61 ? 222 ASP A CB 1 ATOM 1175 C CG . ASP A 1 156 ? 13.581 71.671 44.569 1.00 68.86 ? 222 ASP A CG 1 ATOM 1176 O OD1 . ASP A 1 156 ? 14.391 70.724 44.751 1.00 71.66 ? 222 ASP A OD1 1 ATOM 1177 O OD2 . ASP A 1 156 ? 13.034 71.908 43.459 1.00 77.50 ? 222 ASP A OD2 1 ATOM 1178 N N . VAL A 1 157 ? 16.281 72.723 48.100 1.00 36.34 ? 223 VAL A N 1 ATOM 1179 C CA . VAL A 1 157 ? 17.715 72.974 48.267 1.00 34.18 ? 223 VAL A CA 1 ATOM 1180 C C . VAL A 1 157 ? 18.305 71.968 49.279 1.00 37.84 ? 223 VAL A C 1 ATOM 1181 O O . VAL A 1 157 ? 17.576 71.365 50.075 1.00 38.99 ? 223 VAL A O 1 ATOM 1182 C CB . VAL A 1 157 ? 18.060 74.472 48.683 1.00 35.88 ? 223 VAL A CB 1 ATOM 1183 C CG1 . VAL A 1 157 ? 17.322 75.508 47.857 1.00 34.20 ? 223 VAL A CG1 1 ATOM 1184 C CG2 . VAL A 1 157 ? 17.791 74.726 50.139 1.00 35.53 ? 223 VAL A CG2 1 ATOM 1185 N N . PHE A 1 158 ? 19.628 71.838 49.272 1.00 32.04 ? 224 PHE A N 1 ATOM 1186 C CA . PHE A 1 158 ? 20.402 71.077 50.249 1.00 30.66 ? 224 PHE A CA 1 ATOM 1187 C C . PHE A 1 158 ? 21.777 71.753 50.391 1.00 33.52 ? 224 PHE A C 1 ATOM 1188 O O . PHE A 1 158 ? 22.279 72.343 49.433 1.00 32.41 ? 224 PHE A O 1 ATOM 1189 C CB . PHE A 1 158 ? 20.465 69.567 49.970 1.00 31.71 ? 224 PHE A CB 1 ATOM 1190 C CG . PHE A 1 158 ? 21.110 69.208 48.658 1.00 32.45 ? 224 PHE A CG 1 ATOM 1191 C CD1 . PHE A 1 158 ? 22.485 69.028 48.566 1.00 33.70 ? 224 PHE A CD1 1 ATOM 1192 C CD2 . PHE A 1 158 ? 20.338 69.002 47.518 1.00 33.36 ? 224 PHE A CD2 1 ATOM 1193 C CE1 . PHE A 1 158 ? 23.074 68.689 47.353 1.00 33.47 ? 224 PHE A CE1 1 ATOM 1194 C CE2 . PHE A 1 158 ? 20.932 68.647 46.310 1.00 34.82 ? 224 PHE A CE2 1 ATOM 1195 C CZ . PHE A 1 158 ? 22.296 68.501 46.235 1.00 32.65 ? 224 PHE A CZ 1 ATOM 1196 N N . SER A 1 159 ? 22.357 71.692 51.587 1.00 29.86 ? 225 SER A N 1 ATOM 1197 C CA . SER A 1 159 ? 23.580 72.400 51.940 1.00 27.79 ? 225 SER A CA 1 ATOM 1198 C C . SER A 1 159 ? 24.615 71.498 52.604 1.00 31.68 ? 225 SER A C 1 ATOM 1199 O O . SER A 1 159 ? 24.259 70.586 53.352 1.00 30.22 ? 225 SER A O 1 ATOM 1200 C CB . SER A 1 159 ? 23.238 73.518 52.917 1.00 27.69 ? 225 SER A CB 1 ATOM 1201 O OG . SER A 1 159 ? 22.250 74.371 52.387 1.00 44.66 ? 225 SER A OG 1 ATOM 1202 N N . PHE A 1 160 ? 25.885 71.890 52.463 1.00 29.56 ? 226 PHE A N 1 ATOM 1203 C CA . PHE A 1 160 ? 27.041 71.188 52.984 1.00 29.49 ? 226 PHE A CA 1 ATOM 1204 C C . PHE A 1 160 ? 27.916 72.056 53.815 1.00 34.69 ? 226 PHE A C 1 ATOM 1205 O O . PHE A 1 160 ? 28.306 73.159 53.400 1.00 34.42 ? 226 PHE A O 1 ATOM 1206 C CB . PHE A 1 160 ? 27.894 70.610 51.842 1.00 30.22 ? 226 PHE A CB 1 ATOM 1207 C CG . PHE A 1 160 ? 27.386 69.285 51.330 1.00 31.40 ? 226 PHE A CG 1 ATOM 1208 C CD1 . PHE A 1 160 ? 26.279 69.223 50.488 1.00 34.13 ? 226 PHE A CD1 1 ATOM 1209 C CD2 . PHE A 1 160 ? 28.011 68.092 51.692 1.00 31.05 ? 226 PHE A CD2 1 ATOM 1210 C CE1 . PHE A 1 160 ? 25.808 67.991 50.016 1.00 34.23 ? 226 PHE A CE1 1 ATOM 1211 C CE2 . PHE A 1 160 ? 27.552 66.865 51.206 1.00 32.99 ? 226 PHE A CE2 1 ATOM 1212 C CZ . PHE A 1 160 ? 26.468 66.825 50.355 1.00 32.46 ? 226 PHE A CZ 1 ATOM 1213 N N . TYR A 1 161 ? 28.295 71.504 54.972 1.00 30.33 ? 227 TYR A N 1 ATOM 1214 C CA . TYR A 1 161 ? 29.287 72.079 55.863 1.00 29.07 ? 227 TYR A CA 1 ATOM 1215 C C . TYR A 1 161 ? 30.324 70.983 56.073 1.00 34.40 ? 227 TYR A C 1 ATOM 1216 O O . TYR A 1 161 ? 29.962 69.878 56.469 1.00 36.73 ? 227 TYR A O 1 ATOM 1217 C CB . TYR A 1 161 ? 28.671 72.538 57.200 1.00 28.36 ? 227 TYR A CB 1 ATOM 1218 C CG . TYR A 1 161 ? 29.710 72.804 58.268 1.00 27.34 ? 227 TYR A CG 1 ATOM 1219 C CD1 . TYR A 1 161 ? 30.619 73.853 58.137 1.00 28.84 ? 227 TYR A CD1 1 ATOM 1220 C CD2 . TYR A 1 161 ? 29.832 71.966 59.372 1.00 28.26 ? 227 TYR A CD2 1 ATOM 1221 C CE1 . TYR A 1 161 ? 31.624 74.065 59.078 1.00 27.82 ? 227 TYR A CE1 1 ATOM 1222 C CE2 . TYR A 1 161 ? 30.836 72.165 60.321 1.00 29.94 ? 227 TYR A CE2 1 ATOM 1223 C CZ . TYR A 1 161 ? 31.719 73.231 60.178 1.00 36.16 ? 227 TYR A CZ 1 ATOM 1224 O OH . TYR A 1 161 ? 32.708 73.468 61.094 1.00 39.45 ? 227 TYR A OH 1 ATOM 1225 N N . TYR A 1 162 ? 31.598 71.270 55.780 1.00 30.45 ? 228 TYR A N 1 ATOM 1226 C CA . TYR A 1 162 ? 32.726 70.342 55.991 1.00 29.32 ? 228 TYR A CA 1 ATOM 1227 C C . TYR A 1 162 ? 33.705 71.033 56.952 1.00 36.05 ? 228 TYR A C 1 ATOM 1228 O O . TYR A 1 162 ? 34.199 72.117 56.647 1.00 35.78 ? 228 TYR A O 1 ATOM 1229 C CB . TYR A 1 162 ? 33.448 70.025 54.658 1.00 28.35 ? 228 TYR A CB 1 ATOM 1230 C CG . TYR A 1 162 ? 32.816 68.963 53.776 1.00 28.60 ? 228 TYR A CG 1 ATOM 1231 C CD1 . TYR A 1 162 ? 31.692 68.252 54.195 1.00 29.56 ? 228 TYR A CD1 1 ATOM 1232 C CD2 . TYR A 1 162 ? 33.358 68.652 52.532 1.00 28.60 ? 228 TYR A CD2 1 ATOM 1233 C CE1 . TYR A 1 162 ? 31.111 67.278 53.385 1.00 27.68 ? 228 TYR A CE1 1 ATOM 1234 C CE2 . TYR A 1 162 ? 32.808 67.656 51.735 1.00 29.06 ? 228 TYR A CE2 1 ATOM 1235 C CZ . TYR A 1 162 ? 31.689 66.965 52.167 1.00 33.81 ? 228 TYR A CZ 1 ATOM 1236 O OH . TYR A 1 162 ? 31.153 65.976 51.371 1.00 31.72 ? 228 TYR A OH 1 ATOM 1237 N N . ASN A 1 163 ? 33.965 70.430 58.119 1.00 34.16 ? 229 ASN A N 1 ATOM 1238 C CA . ASN A 1 163 ? 34.897 70.995 59.098 1.00 33.27 ? 229 ASN A CA 1 ATOM 1239 C C . ASN A 1 163 ? 36.341 70.583 58.789 1.00 38.77 ? 229 ASN A C 1 ATOM 1240 O O . ASN A 1 163 ? 36.577 69.694 57.958 1.00 37.86 ? 229 ASN A O 1 ATOM 1241 C CB . ASN A 1 163 ? 34.498 70.507 60.502 1.00 32.93 ? 229 ASN A CB 1 ATOM 1242 C CG . ASN A 1 163 ? 35.011 71.332 61.677 1.00 48.99 ? 229 ASN A CG 1 ATOM 1243 O OD1 . ASN A 1 163 ? 35.835 72.250 61.555 1.00 35.55 ? 229 ASN A OD1 1 ATOM 1244 N ND2 . ASN A 1 163 ? 34.549 71.012 62.859 1.00 41.49 ? 229 ASN A ND2 1 ATOM 1245 N N . ARG A 1 164 ? 37.303 71.241 59.460 1.00 40.21 ? 230 ARG A N 1 ATOM 1246 C CA . ARG A 1 164 ? 38.734 70.916 59.461 1.00 43.25 ? 230 ARG A CA 1 ATOM 1247 C C . ARG A 1 164 ? 38.919 69.769 60.443 1.00 52.84 ? 230 ARG A C 1 ATOM 1248 O O . ARG A 1 164 ? 38.228 69.716 61.449 1.00 50.23 ? 230 ARG A O 1 ATOM 1249 C CB . ARG A 1 164 ? 39.578 72.129 59.889 1.00 47.15 ? 230 ARG A CB 1 ATOM 1250 C CG . ARG A 1 164 ? 39.770 73.160 58.773 1.00 60.85 ? 230 ARG A CG 1 ATOM 1251 C CD . ARG A 1 164 ? 39.011 74.453 59.024 1.00 77.86 ? 230 ARG A CD 1 ATOM 1252 N NE . ARG A 1 164 ? 39.017 75.322 57.839 1.00 90.17 ? 230 ARG A NE 1 ATOM 1253 C CZ . ARG A 1 164 ? 38.308 76.440 57.715 1.00 106.96 ? 230 ARG A CZ 1 ATOM 1254 N NH1 . ARG A 1 164 ? 37.516 76.846 58.701 1.00 103.08 ? 230 ARG A NH1 1 ATOM 1255 N NH2 . ARG A 1 164 ? 38.373 77.152 56.598 1.00 91.12 ? 230 ARG A NH2 1 ATOM 1256 N N . ASP A 1 165 ? 39.830 68.831 60.135 1.00 59.30 ? 231 ASP A N 1 ATOM 1257 C CA . ASP A 1 165 ? 40.048 67.621 60.949 1.00 62.28 ? 231 ASP A CA 1 ATOM 1258 C C . ASP A 1 165 ? 40.626 67.890 62.314 1.00 74.50 ? 231 ASP A C 1 ATOM 1259 O O . ASP A 1 165 ? 41.830 68.129 62.464 1.00 76.20 ? 231 ASP A O 1 ATOM 1260 C CB . ASP A 1 165 ? 40.884 66.556 60.215 1.00 63.54 ? 231 ASP A CB 1 ATOM 1261 C CG . ASP A 1 165 ? 40.833 65.168 60.827 1.00 70.67 ? 231 ASP A CG 1 ATOM 1262 O OD1 . ASP A 1 165 ? 39.860 64.873 61.576 1.00 73.18 ? 231 ASP A OD1 1 ATOM 1263 O OD2 . ASP A 1 165 ? 41.738 64.367 60.540 1.00 72.44 ? 231 ASP A OD2 1 ATOM 1264 N N . SER A 1 166 ? 39.761 67.778 63.318 1.00 74.88 ? 232 SER A N 1 ATOM 1265 C CA . SER A 1 166 ? 40.118 67.951 64.713 1.00 76.53 ? 232 SER A CA 1 ATOM 1266 C C . SER A 1 166 ? 40.308 66.577 65.381 1.00 85.26 ? 232 SER A C 1 ATOM 1267 O O . SER A 1 166 ? 39.667 65.597 64.986 1.00 85.67 ? 232 SER A O 1 ATOM 1268 C CB . SER A 1 166 ? 39.041 68.772 65.419 1.00 79.29 ? 232 SER A CB 1 ATOM 1269 O OG . SER A 1 166 ? 38.903 68.461 66.795 1.00 85.39 ? 232 SER A OG 1 ATOM 1270 N N . GLU A 1 167 ? 41.200 66.512 66.383 1.00 84.48 ? 233 GLU A N 1 ATOM 1271 C CA . GLU A 1 167 ? 41.421 65.295 67.173 1.00 85.27 ? 233 GLU A CA 1 ATOM 1272 C C . GLU A 1 167 ? 40.401 65.220 68.335 1.00 89.82 ? 233 GLU A C 1 ATOM 1273 O O . GLU A 1 167 ? 40.231 64.164 68.956 1.00 89.40 ? 233 GLU A O 1 ATOM 1274 C CB . GLU A 1 167 ? 42.891 65.129 67.636 1.00 86.83 ? 233 GLU A CB 1 ATOM 1275 C CG . GLU A 1 167 ? 43.635 66.393 68.047 1.00 97.47 ? 233 GLU A CG 1 ATOM 1276 C CD . GLU A 1 167 ? 45.142 66.214 68.139 1.00 116.24 ? 233 GLU A CD 1 ATOM 1277 O OE1 . GLU A 1 167 ? 45.690 66.342 69.258 1.00 102.16 ? 233 GLU A OE1 1 ATOM 1278 O OE2 . GLU A 1 167 ? 45.774 65.927 67.095 1.00 109.38 ? 233 GLU A OE2 1 ATOM 1279 N N . ASN A 1 168 ? 39.683 66.340 68.583 1.00 86.19 ? 234 ASN A N 1 ATOM 1280 C CA . ASN A 1 168 ? 38.640 66.415 69.597 1.00 85.60 ? 234 ASN A CA 1 ATOM 1281 C C . ASN A 1 168 ? 37.405 65.697 69.085 1.00 88.44 ? 234 ASN A C 1 ATOM 1282 O O . ASN A 1 168 ? 36.993 65.873 67.931 1.00 87.71 ? 234 ASN A O 1 ATOM 1283 C CB . ASN A 1 168 ? 38.323 67.867 69.985 1.00 85.51 ? 234 ASN A CB 1 ATOM 1284 C CG . ASN A 1 168 ? 39.496 68.628 70.569 1.00 112.32 ? 234 ASN A CG 1 ATOM 1285 O OD1 . ASN A 1 168 ? 40.430 68.059 71.157 1.00 104.23 ? 234 ASN A OD1 1 ATOM 1286 N ND2 . ASN A 1 168 ? 39.468 69.946 70.428 1.00 107.39 ? 234 ASN A ND2 1 ATOM 1287 N N . SER A 1 169 ? 36.858 64.839 69.938 1.00 84.21 ? 235 SER A N 1 ATOM 1288 C CA . SER A 1 169 ? 35.674 64.043 69.657 1.00 83.39 ? 235 SER A CA 1 ATOM 1289 C C . SER A 1 169 ? 34.414 64.926 69.617 1.00 84.53 ? 235 SER A C 1 ATOM 1290 O O . SER A 1 169 ? 33.482 64.624 68.861 1.00 85.31 ? 235 SER A O 1 ATOM 1291 C CB . SER A 1 169 ? 35.540 62.931 70.694 1.00 87.25 ? 235 SER A CB 1 ATOM 1292 O OG . SER A 1 169 ? 36.719 62.143 70.732 1.00 95.83 ? 235 SER A OG 1 ATOM 1293 N N . GLN A 1 170 ? 34.408 66.038 70.392 1.00 77.07 ? 236 GLN A N 1 ATOM 1294 C CA . GLN A 1 170 ? 33.296 67.006 70.465 1.00 74.77 ? 236 GLN A CA 1 ATOM 1295 C C . GLN A 1 170 ? 33.143 67.841 69.174 1.00 73.23 ? 236 GLN A C 1 ATOM 1296 O O . GLN A 1 170 ? 32.172 68.595 69.033 1.00 73.01 ? 236 GLN A O 1 ATOM 1297 C CB . GLN A 1 170 ? 33.467 67.925 71.690 1.00 75.98 ? 236 GLN A CB 1 ATOM 1298 N N . SER A 1 171 ? 34.109 67.713 68.241 1.00 64.62 ? 237 SER A N 1 ATOM 1299 C CA . SER A 1 171 ? 34.106 68.427 66.970 1.00 61.64 ? 237 SER A CA 1 ATOM 1300 C C . SER A 1 171 ? 33.238 67.719 65.939 1.00 58.86 ? 237 SER A C 1 ATOM 1301 O O . SER A 1 171 ? 33.454 66.545 65.620 1.00 58.45 ? 237 SER A O 1 ATOM 1302 C CB . SER A 1 171 ? 35.528 68.581 66.440 1.00 64.83 ? 237 SER A CB 1 ATOM 1303 O OG . SER A 1 171 ? 35.606 69.551 65.408 1.00 73.08 ? 237 SER A OG 1 ATOM 1304 N N . LEU A 1 172 ? 32.244 68.444 65.430 1.00 49.95 ? 238 LEU A N 1 ATOM 1305 C CA . LEU A 1 172 ? 31.345 67.999 64.374 1.00 46.79 ? 238 LEU A CA 1 ATOM 1306 C C . LEU A 1 172 ? 32.193 67.884 63.073 1.00 43.94 ? 238 LEU A C 1 ATOM 1307 O O . LEU A 1 172 ? 32.790 68.891 62.668 1.00 41.00 ? 238 LEU A O 1 ATOM 1308 C CB . LEU A 1 172 ? 30.250 69.091 64.214 1.00 46.49 ? 238 LEU A CB 1 ATOM 1309 C CG . LEU A 1 172 ? 29.255 68.939 63.065 1.00 50.29 ? 238 LEU A CG 1 ATOM 1310 C CD1 . LEU A 1 172 ? 28.190 67.949 63.408 1.00 50.60 ? 238 LEU A CD1 1 ATOM 1311 C CD2 . LEU A 1 172 ? 28.634 70.260 62.707 1.00 49.75 ? 238 LEU A CD2 1 ATOM 1312 N N . GLY A 1 173 ? 32.233 66.687 62.452 1.00 37.61 ? 239 GLY A N 1 ATOM 1313 C CA . GLY A 1 173 ? 32.980 66.456 61.209 1.00 36.35 ? 239 GLY A CA 1 ATOM 1314 C C . GLY A 1 173 ? 32.423 67.229 60.025 1.00 39.36 ? 239 GLY A C 1 ATOM 1315 O O . GLY A 1 173 ? 33.165 67.653 59.132 1.00 39.46 ? 239 GLY A O 1 ATOM 1316 N N . GLY A 1 174 ? 31.112 67.413 60.033 1.00 34.50 ? 240 GLY A N 1 ATOM 1317 C CA . GLY A 1 174 ? 30.388 68.119 58.994 1.00 34.07 ? 240 GLY A CA 1 ATOM 1318 C C . GLY A 1 174 ? 28.896 67.943 59.153 1.00 37.46 ? 240 GLY A C 1 ATOM 1319 O O . GLY A 1 174 ? 28.432 67.284 60.093 1.00 35.82 ? 240 GLY A O 1 ATOM 1320 N N . GLN A 1 175 ? 28.133 68.553 58.242 1.00 33.48 ? 241 GLN A N 1 ATOM 1321 C CA . GLN A 1 175 ? 26.683 68.512 58.292 1.00 33.11 ? 241 GLN A CA 1 ATOM 1322 C C . GLN A 1 175 ? 26.075 68.828 56.938 1.00 39.41 ? 241 GLN A C 1 ATOM 1323 O O . GLN A 1 175 ? 26.480 69.797 56.274 1.00 41.76 ? 241 GLN A O 1 ATOM 1324 C CB . GLN A 1 175 ? 26.184 69.528 59.347 1.00 34.41 ? 241 GLN A CB 1 ATOM 1325 C CG . GLN A 1 175 ? 24.693 69.487 59.683 1.00 39.94 ? 241 GLN A CG 1 ATOM 1326 C CD . GLN A 1 175 ? 24.212 70.840 60.183 1.00 52.31 ? 241 GLN A CD 1 ATOM 1327 O OE1 . GLN A 1 175 ? 24.445 71.896 59.576 1.00 39.49 ? 241 GLN A OE1 1 ATOM 1328 N NE2 . GLN A 1 175 ? 23.523 70.833 61.301 1.00 44.44 ? 241 GLN A NE2 1 ATOM 1329 N N . ILE A 1 176 ? 25.114 67.991 56.523 1.00 35.18 ? 242 ILE A N 1 ATOM 1330 C CA . ILE A 1 176 ? 24.301 68.212 55.335 1.00 35.40 ? 242 ILE A CA 1 ATOM 1331 C C . ILE A 1 176 ? 22.858 68.576 55.794 1.00 40.06 ? 242 ILE A C 1 ATOM 1332 O O . ILE A 1 176 ? 22.276 67.884 56.633 1.00 39.67 ? 242 ILE A O 1 ATOM 1333 C CB . ILE A 1 176 ? 24.366 67.143 54.190 1.00 38.62 ? 242 ILE A CB 1 ATOM 1334 C CG1 . ILE A 1 176 ? 23.117 67.216 53.262 1.00 38.58 ? 242 ILE A CG1 1 ATOM 1335 C CG2 . ILE A 1 176 ? 24.633 65.721 54.668 1.00 39.66 ? 242 ILE A CG2 1 ATOM 1336 C CD1 . ILE A 1 176 ? 23.167 66.344 51.962 1.00 43.67 ? 242 ILE A CD1 1 ATOM 1337 N N . VAL A 1 177 ? 22.336 69.716 55.310 1.00 36.65 ? 243 VAL A N 1 ATOM 1338 C CA . VAL A 1 177 ? 20.973 70.157 55.618 1.00 35.57 ? 243 VAL A CA 1 ATOM 1339 C C . VAL A 1 177 ? 20.138 69.938 54.354 1.00 37.70 ? 243 VAL A C 1 ATOM 1340 O O . VAL A 1 177 ? 20.499 70.449 53.293 1.00 34.00 ? 243 VAL A O 1 ATOM 1341 C CB . VAL A 1 177 ? 20.900 71.635 56.105 1.00 39.17 ? 243 VAL A CB 1 ATOM 1342 C CG1 . VAL A 1 177 ? 19.457 72.037 56.434 1.00 38.34 ? 243 VAL A CG1 1 ATOM 1343 C CG2 . VAL A 1 177 ? 21.813 71.868 57.310 1.00 38.85 ? 243 VAL A CG2 1 ATOM 1344 N N . LEU A 1 178 ? 19.066 69.127 54.454 1.00 35.22 ? 244 LEU A N 1 ATOM 1345 C CA . LEU A 1 178 ? 18.131 68.894 53.351 1.00 34.53 ? 244 LEU A CA 1 ATOM 1346 C C . LEU A 1 178 ? 16.938 69.829 53.590 1.00 39.91 ? 244 LEU A C 1 ATOM 1347 O O . LEU A 1 178 ? 16.359 69.832 54.680 1.00 39.01 ? 244 LEU A O 1 ATOM 1348 C CB . LEU A 1 178 ? 17.650 67.438 53.302 1.00 34.29 ? 244 LEU A CB 1 ATOM 1349 C CG . LEU A 1 178 ? 18.679 66.306 53.224 1.00 38.69 ? 244 LEU A CG 1 ATOM 1350 C CD1 . LEU A 1 178 ? 18.006 64.977 53.390 1.00 38.61 ? 244 LEU A CD1 1 ATOM 1351 C CD2 . LEU A 1 178 ? 19.430 66.302 51.908 1.00 40.76 ? 244 LEU A CD2 1 ATOM 1352 N N . GLY A 1 179 ? 16.619 70.651 52.604 1.00 38.32 ? 245 GLY A N 1 ATOM 1353 C CA . GLY A 1 179 ? 15.511 71.589 52.708 1.00 39.31 ? 245 GLY A CA 1 ATOM 1354 C C . GLY A 1 179 ? 15.867 73.018 53.090 1.00 45.08 ? 245 GLY A C 1 ATOM 1355 O O . GLY A 1 179 ? 14.975 73.861 53.194 1.00 45.38 ? 245 GLY A O 1 ATOM 1356 N N . GLY A 1 180 ? 17.155 73.298 53.284 1.00 42.01 ? 246 GLY A N 1 ATOM 1357 C CA . GLY A 1 180 ? 17.625 74.623 53.678 1.00 41.41 ? 246 GLY A CA 1 ATOM 1358 C C . GLY A 1 180 ? 19.115 74.691 53.935 1.00 46.03 ? 246 GLY A C 1 ATOM 1359 O O . GLY A 1 180 ? 19.867 73.860 53.433 1.00 46.59 ? 246 GLY A O 1 ATOM 1360 N N . SER A 1 181 ? 19.549 75.699 54.711 1.00 41.99 ? 247 SER A N 1 ATOM 1361 C CA . SER A 1 181 ? 20.930 75.970 55.132 1.00 39.93 ? 247 SER A CA 1 ATOM 1362 C C . SER A 1 181 ? 20.972 76.216 56.627 1.00 42.76 ? 247 SER A C 1 ATOM 1363 O O . SER A 1 181 ? 19.964 76.651 57.192 1.00 42.36 ? 247 SER A O 1 ATOM 1364 C CB . SER A 1 181 ? 21.466 77.211 54.438 1.00 41.82 ? 247 SER A CB 1 ATOM 1365 O OG . SER A 1 181 ? 22.253 76.823 53.332 1.00 53.36 ? 247 SER A OG 1 ATOM 1366 N N . ASP A 1 182 ? 22.134 75.967 57.269 1.00 38.28 ? 248 ASP A N 1 ATOM 1367 C CA . ASP A 1 182 ? 22.305 76.195 58.706 1.00 37.87 ? 248 ASP A CA 1 ATOM 1368 C C . ASP A 1 182 ? 23.126 77.484 58.959 1.00 41.47 ? 248 ASP A C 1 ATOM 1369 O O . ASP A 1 182 ? 24.355 77.473 58.792 1.00 39.19 ? 248 ASP A O 1 ATOM 1370 C CB . ASP A 1 182 ? 22.916 74.967 59.412 1.00 38.58 ? 248 ASP A CB 1 ATOM 1371 C CG . ASP A 1 182 ? 22.951 75.053 60.922 1.00 43.13 ? 248 ASP A CG 1 ATOM 1372 O OD1 . ASP A 1 182 ? 22.635 76.134 61.469 1.00 44.46 ? 248 ASP A OD1 1 ATOM 1373 O OD2 . ASP A 1 182 ? 23.317 74.053 61.558 1.00 48.30 ? 248 ASP A OD2 1 ATOM 1374 N N . PRO A 1 183 ? 22.451 78.580 59.418 1.00 39.24 ? 249 PRO A N 1 ATOM 1375 C CA . PRO A 1 183 ? 23.167 79.854 59.671 1.00 38.75 ? 249 PRO A CA 1 ATOM 1376 C C . PRO A 1 183 ? 24.265 79.797 60.741 1.00 42.21 ? 249 PRO A C 1 ATOM 1377 O O . PRO A 1 183 ? 25.122 80.678 60.774 1.00 40.54 ? 249 PRO A O 1 ATOM 1378 C CB . PRO A 1 183 ? 22.049 80.841 60.044 1.00 40.22 ? 249 PRO A CB 1 ATOM 1379 C CG . PRO A 1 183 ? 20.794 80.195 59.650 1.00 44.40 ? 249 PRO A CG 1 ATOM 1380 C CD . PRO A 1 183 ? 21.008 78.722 59.702 1.00 40.31 ? 249 PRO A CD 1 ATOM 1381 N N . GLN A 1 184 ? 24.267 78.739 61.577 1.00 39.70 ? 250 GLN A N 1 ATOM 1382 C CA . GLN A 1 184 ? 25.301 78.526 62.583 1.00 39.09 ? 250 GLN A CA 1 ATOM 1383 C C . GLN A 1 184 ? 26.616 78.079 61.934 1.00 41.33 ? 250 GLN A C 1 ATOM 1384 O O . GLN A 1 184 ? 27.642 78.106 62.618 1.00 41.50 ? 250 GLN A O 1 ATOM 1385 C CB . GLN A 1 184 ? 24.838 77.487 63.626 1.00 40.50 ? 250 GLN A CB 1 ATOM 1386 N N . HIS A 1 185 ? 26.602 77.659 60.637 1.00 36.52 ? 251 HIS A N 1 ATOM 1387 C CA . HIS A 1 185 ? 27.831 77.173 59.982 1.00 35.88 ? 251 HIS A CA 1 ATOM 1388 C C . HIS A 1 185 ? 28.322 78.033 58.787 1.00 39.95 ? 251 HIS A C 1 ATOM 1389 O O . HIS A 1 185 ? 29.241 77.619 58.079 1.00 40.93 ? 251 HIS A O 1 ATOM 1390 C CB . HIS A 1 185 ? 27.737 75.679 59.625 1.00 35.68 ? 251 HIS A CB 1 ATOM 1391 C CG . HIS A 1 185 ? 27.785 74.833 60.869 1.00 38.51 ? 251 HIS A CG 1 ATOM 1392 N ND1 . HIS A 1 185 ? 28.793 75.006 61.829 1.00 40.14 ? 251 HIS A ND1 1 ATOM 1393 C CD2 . HIS A 1 185 ? 26.909 73.914 61.326 1.00 39.75 ? 251 HIS A CD2 1 ATOM 1394 C CE1 . HIS A 1 185 ? 28.510 74.165 62.810 1.00 39.15 ? 251 HIS A CE1 1 ATOM 1395 N NE2 . HIS A 1 185 ? 27.385 73.492 62.563 1.00 39.91 ? 251 HIS A NE2 1 ATOM 1396 N N . TYR A 1 186 ? 27.806 79.266 58.651 1.00 35.69 ? 252 TYR A N 1 ATOM 1397 C CA . TYR A 1 186 ? 28.304 80.270 57.699 1.00 35.29 ? 252 TYR A CA 1 ATOM 1398 C C . TYR A 1 186 ? 28.087 81.668 58.274 1.00 40.79 ? 252 TYR A C 1 ATOM 1399 O O . TYR A 1 186 ? 27.305 81.843 59.211 1.00 40.29 ? 252 TYR A O 1 ATOM 1400 C CB . TYR A 1 186 ? 27.695 80.141 56.287 1.00 35.33 ? 252 TYR A CB 1 ATOM 1401 C CG . TYR A 1 186 ? 26.217 80.451 56.210 1.00 35.79 ? 252 TYR A CG 1 ATOM 1402 C CD1 . TYR A 1 186 ? 25.768 81.736 55.919 1.00 37.61 ? 252 TYR A CD1 1 ATOM 1403 C CD2 . TYR A 1 186 ? 25.267 79.441 56.331 1.00 36.33 ? 252 TYR A CD2 1 ATOM 1404 C CE1 . TYR A 1 186 ? 24.404 82.024 55.820 1.00 37.46 ? 252 TYR A CE1 1 ATOM 1405 C CE2 . TYR A 1 186 ? 23.900 79.719 56.258 1.00 36.78 ? 252 TYR A CE2 1 ATOM 1406 C CZ . TYR A 1 186 ? 23.473 81.017 56.020 1.00 41.96 ? 252 TYR A CZ 1 ATOM 1407 O OH . TYR A 1 186 ? 22.131 81.300 55.926 1.00 41.87 ? 252 TYR A OH 1 ATOM 1408 N N . GLU A 1 187 ? 28.753 82.658 57.689 1.00 37.08 ? 253 GLU A N 1 ATOM 1409 C CA . GLU A 1 187 ? 28.610 84.064 58.059 1.00 35.78 ? 253 GLU A CA 1 ATOM 1410 C C . GLU A 1 187 ? 28.594 84.900 56.779 1.00 41.97 ? 253 GLU A C 1 ATOM 1411 O O . GLU A 1 187 ? 28.928 84.378 55.715 1.00 41.76 ? 253 GLU A O 1 ATOM 1412 C CB . GLU A 1 187 ? 29.692 84.525 59.061 1.00 36.49 ? 253 GLU A CB 1 ATOM 1413 C CG . GLU A 1 187 ? 31.113 84.137 58.688 1.00 40.06 ? 253 GLU A CG 1 ATOM 1414 C CD . GLU A 1 187 ? 32.125 84.432 59.766 1.00 49.64 ? 253 GLU A CD 1 ATOM 1415 O OE1 . GLU A 1 187 ? 31.722 84.697 60.922 1.00 48.93 ? 253 GLU A OE1 1 ATOM 1416 O OE2 . GLU A 1 187 ? 33.333 84.371 59.453 1.00 43.12 ? 253 GLU A OE2 1 ATOM 1417 N N . GLY A 1 188 ? 28.186 86.169 56.879 1.00 40.18 ? 254 GLY A N 1 ATOM 1418 C CA . GLY A 1 188 ? 27.996 87.030 55.721 1.00 39.70 ? 254 GLY A CA 1 ATOM 1419 C C . GLY A 1 188 ? 26.784 86.534 54.952 1.00 43.01 ? 254 GLY A C 1 ATOM 1420 O O . GLY A 1 188 ? 25.924 85.839 55.509 1.00 42.17 ? 254 GLY A O 1 ATOM 1421 N N . ASN A 1 189 ? 26.729 86.836 53.663 1.00 40.74 ? 255 ASN A N 1 ATOM 1422 C CA . ASN A 1 189 ? 25.610 86.378 52.830 1.00 40.85 ? 255 ASN A CA 1 ATOM 1423 C C . ASN A 1 189 ? 26.085 85.434 51.748 1.00 40.94 ? 255 ASN A C 1 ATOM 1424 O O . ASN A 1 189 ? 27.273 85.437 51.397 1.00 37.57 ? 255 ASN A O 1 ATOM 1425 C CB . ASN A 1 189 ? 24.903 87.573 52.158 1.00 45.77 ? 255 ASN A CB 1 ATOM 1426 C CG . ASN A 1 189 ? 24.392 88.623 53.096 1.00 69.79 ? 255 ASN A CG 1 ATOM 1427 O OD1 . ASN A 1 189 ? 24.822 89.765 53.016 1.00 62.53 ? 255 ASN A OD1 1 ATOM 1428 N ND2 . ASN A 1 189 ? 23.460 88.267 53.981 1.00 62.18 ? 255 ASN A ND2 1 ATOM 1429 N N . PHE A 1 190 ? 25.139 84.674 51.178 1.00 37.99 ? 256 PHE A N 1 ATOM 1430 C CA . PHE A 1 190 ? 25.438 83.805 50.059 1.00 37.80 ? 256 PHE A CA 1 ATOM 1431 C C . PHE A 1 190 ? 25.519 84.648 48.805 1.00 44.93 ? 256 PHE A C 1 ATOM 1432 O O . PHE A 1 190 ? 24.811 85.642 48.661 1.00 45.01 ? 256 PHE A O 1 ATOM 1433 C CB . PHE A 1 190 ? 24.351 82.748 49.869 1.00 38.83 ? 256 PHE A CB 1 ATOM 1434 C CG . PHE A 1 190 ? 24.362 81.562 50.809 1.00 40.61 ? 256 PHE A CG 1 ATOM 1435 C CD1 . PHE A 1 190 ? 25.313 80.548 50.671 1.00 43.74 ? 256 PHE A CD1 1 ATOM 1436 C CD2 . PHE A 1 190 ? 23.366 81.408 51.772 1.00 42.47 ? 256 PHE A CD2 1 ATOM 1437 C CE1 . PHE A 1 190 ? 25.309 79.439 51.527 1.00 44.55 ? 256 PHE A CE1 1 ATOM 1438 C CE2 . PHE A 1 190 ? 23.349 80.291 52.616 1.00 45.02 ? 256 PHE A CE2 1 ATOM 1439 C CZ . PHE A 1 190 ? 24.320 79.314 52.488 1.00 44.01 ? 256 PHE A CZ 1 ATOM 1440 N N . HIS A 1 191 ? 26.394 84.236 47.905 1.00 44.45 ? 257 HIS A N 1 ATOM 1441 C CA . HIS A 1 191 ? 26.622 84.774 46.575 1.00 45.47 ? 257 HIS A CA 1 ATOM 1442 C C . HIS A 1 191 ? 26.378 83.557 45.692 1.00 48.14 ? 257 HIS A C 1 ATOM 1443 O O . HIS A 1 191 ? 26.996 82.502 45.942 1.00 46.28 ? 257 HIS A O 1 ATOM 1444 C CB . HIS A 1 191 ? 28.058 85.340 46.437 1.00 47.18 ? 257 HIS A CB 1 ATOM 1445 C CG . HIS A 1 191 ? 28.277 86.525 47.325 1.00 52.25 ? 257 HIS A CG 1 ATOM 1446 N ND1 . HIS A 1 191 ? 28.848 86.391 48.590 1.00 54.87 ? 257 HIS A ND1 1 ATOM 1447 C CD2 . HIS A 1 191 ? 27.863 87.808 47.171 1.00 54.92 ? 257 HIS A CD2 1 ATOM 1448 C CE1 . HIS A 1 191 ? 28.809 87.598 49.135 1.00 54.26 ? 257 HIS A CE1 1 ATOM 1449 N NE2 . HIS A 1 191 ? 28.230 88.485 48.319 1.00 54.69 ? 257 HIS A NE2 1 ATOM 1450 N N . TYR A 1 192 ? 25.416 83.672 44.727 1.00 43.00 ? 258 TYR A N 1 ATOM 1451 C CA . TYR A 1 192 ? 25.034 82.595 43.829 1.00 40.89 ? 258 TYR A CA 1 ATOM 1452 C C . TYR A 1 192 ? 25.631 82.733 42.437 1.00 47.28 ? 258 TYR A C 1 ATOM 1453 O O . TYR A 1 192 ? 25.929 83.832 41.970 1.00 47.10 ? 258 TYR A O 1 ATOM 1454 C CB . TYR A 1 192 ? 23.515 82.415 43.773 1.00 40.59 ? 258 TYR A CB 1 ATOM 1455 C CG . TYR A 1 192 ? 22.876 82.202 45.126 1.00 41.50 ? 258 TYR A CG 1 ATOM 1456 C CD1 . TYR A 1 192 ? 22.523 83.286 45.928 1.00 42.76 ? 258 TYR A CD1 1 ATOM 1457 C CD2 . TYR A 1 192 ? 22.597 80.916 45.599 1.00 41.69 ? 258 TYR A CD2 1 ATOM 1458 C CE1 . TYR A 1 192 ? 21.950 83.101 47.185 1.00 41.66 ? 258 TYR A CE1 1 ATOM 1459 C CE2 . TYR A 1 192 ? 22.020 80.718 46.856 1.00 42.03 ? 258 TYR A CE2 1 ATOM 1460 C CZ . TYR A 1 192 ? 21.692 81.818 47.643 1.00 46.76 ? 258 TYR A CZ 1 ATOM 1461 O OH . TYR A 1 192 ? 21.108 81.662 48.879 1.00 47.27 ? 258 TYR A OH 1 ATOM 1462 N N . ILE A 1 193 ? 25.883 81.579 41.819 1.00 44.49 ? 259 ILE A N 1 ATOM 1463 C CA . ILE A 1 193 ? 26.389 81.423 40.467 1.00 43.45 ? 259 ILE A CA 1 ATOM 1464 C C . ILE A 1 193 ? 25.411 80.422 39.851 1.00 48.92 ? 259 ILE A C 1 ATOM 1465 O O . ILE A 1 193 ? 25.126 79.388 40.451 1.00 49.03 ? 259 ILE A O 1 ATOM 1466 C CB . ILE A 1 193 ? 27.867 80.941 40.402 1.00 45.67 ? 259 ILE A CB 1 ATOM 1467 C CG1 . ILE A 1 193 ? 28.827 81.762 41.343 1.00 46.51 ? 259 ILE A CG1 1 ATOM 1468 C CG2 . ILE A 1 193 ? 28.383 80.936 38.951 1.00 41.21 ? 259 ILE A CG2 1 ATOM 1469 C CD1 . ILE A 1 193 ? 29.137 81.127 42.676 1.00 48.48 ? 259 ILE A CD1 1 ATOM 1470 N N . ASN A 1 194 ? 24.845 80.753 38.696 1.00 46.10 ? 260 ASN A N 1 ATOM 1471 C CA . ASN A 1 194 ? 23.893 79.865 38.035 1.00 45.29 ? 260 ASN A CA 1 ATOM 1472 C C . ASN A 1 194 ? 24.631 78.725 37.361 1.00 47.32 ? 260 ASN A C 1 ATOM 1473 O O . ASN A 1 194 ? 25.795 78.883 36.984 1.00 46.54 ? 260 ASN A O 1 ATOM 1474 C CB . ASN A 1 194 ? 23.036 80.618 37.002 1.00 44.32 ? 260 ASN A CB 1 ATOM 1475 C CG . ASN A 1 194 ? 22.278 81.780 37.566 1.00 67.64 ? 260 ASN A CG 1 ATOM 1476 O OD1 . ASN A 1 194 ? 21.122 81.675 37.993 1.00 61.03 ? 260 ASN A OD1 1 ATOM 1477 N ND2 . ASN A 1 194 ? 22.920 82.922 37.526 1.00 66.86 ? 260 ASN A ND2 1 ATOM 1478 N N . LEU A 1 195 ? 23.950 77.577 37.211 1.00 42.33 ? 261 LEU A N 1 ATOM 1479 C CA . LEU A 1 195 ? 24.527 76.422 36.532 1.00 41.60 ? 261 LEU A CA 1 ATOM 1480 C C . LEU A 1 195 ? 24.606 76.713 35.045 1.00 48.63 ? 261 LEU A C 1 ATOM 1481 O O . LEU A 1 195 ? 23.721 77.397 34.524 1.00 49.76 ? 261 LEU A O 1 ATOM 1482 C CB . LEU A 1 195 ? 23.663 75.156 36.761 1.00 40.08 ? 261 LEU A CB 1 ATOM 1483 C CG . LEU A 1 195 ? 23.443 74.676 38.218 1.00 42.28 ? 261 LEU A CG 1 ATOM 1484 C CD1 . LEU A 1 195 ? 22.680 73.374 38.260 1.00 41.83 ? 261 LEU A CD1 1 ATOM 1485 C CD2 . LEU A 1 195 ? 24.744 74.572 38.990 1.00 41.29 ? 261 LEU A CD2 1 ATOM 1486 N N . ILE A 1 196 ? 25.645 76.193 34.360 1.00 47.26 ? 262 ILE A N 1 ATOM 1487 C CA . ILE A 1 196 ? 25.798 76.282 32.903 1.00 49.47 ? 262 ILE A CA 1 ATOM 1488 C C . ILE A 1 196 ? 24.493 75.742 32.288 1.00 58.12 ? 262 ILE A C 1 ATOM 1489 O O . ILE A 1 196 ? 23.901 76.380 31.406 1.00 59.88 ? 262 ILE A O 1 ATOM 1490 C CB . ILE A 1 196 ? 27.010 75.435 32.419 1.00 53.04 ? 262 ILE A CB 1 ATOM 1491 C CG1 . ILE A 1 196 ? 28.362 75.938 32.997 1.00 53.52 ? 262 ILE A CG1 1 ATOM 1492 C CG2 . ILE A 1 196 ? 27.056 75.299 30.882 1.00 53.80 ? 262 ILE A CG2 1 ATOM 1493 C CD1 . ILE A 1 196 ? 28.795 77.272 32.584 1.00 66.75 ? 262 ILE A CD1 1 ATOM 1494 N N . LYS A 1 197 ? 24.042 74.579 32.803 1.00 54.81 ? 263 LYS A N 1 ATOM 1495 C CA . LYS A 1 197 ? 22.834 73.858 32.404 1.00 54.80 ? 263 LYS A CA 1 ATOM 1496 C C . LYS A 1 197 ? 22.388 72.940 33.528 1.00 58.55 ? 263 LYS A C 1 ATOM 1497 O O . LYS A 1 197 ? 23.227 72.421 34.268 1.00 59.56 ? 263 LYS A O 1 ATOM 1498 C CB . LYS A 1 197 ? 23.102 73.001 31.142 1.00 57.05 ? 263 LYS A CB 1 ATOM 1499 C CG . LYS A 1 197 ? 24.293 72.051 31.264 1.00 57.79 ? 263 LYS A CG 1 ATOM 1500 C CD . LYS A 1 197 ? 24.350 71.021 30.145 1.00 62.49 ? 263 LYS A CD 1 ATOM 1501 C CE . LYS A 1 197 ? 25.518 70.073 30.322 1.00 62.65 ? 263 LYS A CE 1 ATOM 1502 N NZ . LYS A 1 197 ? 26.841 70.763 30.241 1.00 65.70 ? 263 LYS A NZ 1 ATOM 1503 N N . THR A 1 198 ? 21.080 72.684 33.614 1.00 53.48 ? 264 THR A N 1 ATOM 1504 C CA . THR A 1 198 ? 20.494 71.733 34.561 1.00 52.22 ? 264 THR A CA 1 ATOM 1505 C C . THR A 1 198 ? 21.056 70.312 34.251 1.00 53.33 ? 264 THR A C 1 ATOM 1506 O O . THR A 1 198 ? 21.496 70.037 33.128 1.00 52.01 ? 264 THR A O 1 ATOM 1507 C CB . THR A 1 198 ? 18.946 71.846 34.534 1.00 60.29 ? 264 THR A CB 1 ATOM 1508 O OG1 . THR A 1 198 ? 18.389 71.187 35.675 1.00 63.82 ? 264 THR A OG1 1 ATOM 1509 C CG2 . THR A 1 198 ? 18.315 71.315 33.229 1.00 56.61 ? 264 THR A CG2 1 ATOM 1510 N N . GLY A 1 199 ? 21.104 69.458 35.260 1.00 47.98 ? 265 GLY A N 1 ATOM 1511 C CA . GLY A 1 199 ? 21.631 68.113 35.069 1.00 46.32 ? 265 GLY A CA 1 ATOM 1512 C C . GLY A 1 199 ? 23.041 67.888 35.577 1.00 45.91 ? 265 GLY A C 1 ATOM 1513 O O . GLY A 1 199 ? 23.449 66.738 35.706 1.00 43.82 ? 265 GLY A O 1 ATOM 1514 N N . VAL A 1 200 ? 23.813 68.979 35.847 1.00 41.29 ? 266 VAL A N 1 ATOM 1515 C CA . VAL A 1 200 ? 25.194 68.933 36.350 1.00 40.74 ? 266 VAL A CA 1 ATOM 1516 C C . VAL A 1 200 ? 25.419 70.074 37.348 1.00 45.78 ? 266 VAL A C 1 ATOM 1517 O O . VAL A 1 200 ? 25.105 71.220 37.024 1.00 47.30 ? 266 VAL A O 1 ATOM 1518 C CB . VAL A 1 200 ? 26.285 69.000 35.237 1.00 43.88 ? 266 VAL A CB 1 ATOM 1519 C CG1 . VAL A 1 200 ? 27.613 68.451 35.746 1.00 42.75 ? 266 VAL A CG1 1 ATOM 1520 C CG2 . VAL A 1 200 ? 25.872 68.269 33.958 1.00 43.94 ? 266 VAL A CG2 1 ATOM 1521 N N . TRP A 1 201 ? 26.030 69.782 38.531 1.00 40.48 ? 267 TRP A N 1 ATOM 1522 C CA . TRP A 1 201 ? 26.391 70.810 39.533 1.00 38.54 ? 267 TRP A CA 1 ATOM 1523 C C . TRP A 1 201 ? 27.701 71.440 39.084 1.00 42.86 ? 267 TRP A C 1 ATOM 1524 O O . TRP A 1 201 ? 28.742 71.285 39.721 1.00 42.65 ? 267 TRP A O 1 ATOM 1525 C CB . TRP A 1 201 ? 26.488 70.224 40.961 1.00 35.46 ? 267 TRP A CB 1 ATOM 1526 C CG . TRP A 1 201 ? 25.172 69.769 41.534 1.00 35.00 ? 267 TRP A CG 1 ATOM 1527 C CD1 . TRP A 1 201 ? 24.801 68.489 41.833 1.00 37.20 ? 267 TRP A CD1 1 ATOM 1528 C CD2 . TRP A 1 201 ? 24.051 70.608 41.883 1.00 34.58 ? 267 TRP A CD2 1 ATOM 1529 N NE1 . TRP A 1 201 ? 23.531 68.477 42.377 1.00 35.94 ? 267 TRP A NE1 1 ATOM 1530 C CE2 . TRP A 1 201 ? 23.041 69.762 42.399 1.00 37.69 ? 267 TRP A CE2 1 ATOM 1531 C CE3 . TRP A 1 201 ? 23.795 71.995 41.778 1.00 35.41 ? 267 TRP A CE3 1 ATOM 1532 C CZ2 . TRP A 1 201 ? 21.811 70.259 42.842 1.00 37.06 ? 267 TRP A CZ2 1 ATOM 1533 C CZ3 . TRP A 1 201 ? 22.570 72.482 42.193 1.00 36.28 ? 267 TRP A CZ3 1 ATOM 1534 C CH2 . TRP A 1 201 ? 21.602 71.623 42.742 1.00 36.90 ? 267 TRP A CH2 1 ATOM 1535 N N . GLN A 1 202 ? 27.642 72.107 37.930 1.00 40.40 ? 268 GLN A N 1 ATOM 1536 C CA . GLN A 1 202 ? 28.790 72.709 37.265 1.00 40.61 ? 268 GLN A CA 1 ATOM 1537 C C . GLN A 1 202 ? 28.480 74.138 36.891 1.00 44.11 ? 268 GLN A C 1 ATOM 1538 O O . GLN A 1 202 ? 27.401 74.435 36.368 1.00 43.86 ? 268 GLN A O 1 ATOM 1539 C CB . GLN A 1 202 ? 29.148 71.895 36.016 1.00 42.07 ? 268 GLN A CB 1 ATOM 1540 C CG . GLN A 1 202 ? 30.470 72.290 35.357 1.00 36.42 ? 268 GLN A CG 1 ATOM 1541 C CD . GLN A 1 202 ? 30.801 71.329 34.269 1.00 47.30 ? 268 GLN A CD 1 ATOM 1542 O OE1 . GLN A 1 202 ? 29.981 71.066 33.387 1.00 43.79 ? 268 GLN A OE1 1 ATOM 1543 N NE2 . GLN A 1 202 ? 31.999 70.750 34.333 1.00 40.07 ? 268 GLN A NE2 1 ATOM 1544 N N . ILE A 1 203 ? 29.432 75.025 37.184 1.00 39.25 ? 269 ILE A N 1 ATOM 1545 C CA . ILE A 1 203 ? 29.315 76.459 36.947 1.00 37.85 ? 269 ILE A CA 1 ATOM 1546 C C . ILE A 1 203 ? 30.484 76.975 36.100 1.00 42.02 ? 269 ILE A C 1 ATOM 1547 O O . ILE A 1 203 ? 31.544 76.328 36.011 1.00 39.83 ? 269 ILE A O 1 ATOM 1548 C CB . ILE A 1 203 ? 29.228 77.224 38.302 1.00 39.75 ? 269 ILE A CB 1 ATOM 1549 C CG1 . ILE A 1 203 ? 30.501 76.977 39.190 1.00 40.03 ? 269 ILE A CG1 1 ATOM 1550 C CG2 . ILE A 1 203 ? 27.916 76.925 39.036 1.00 38.50 ? 269 ILE A CG2 1 ATOM 1551 C CD1 . ILE A 1 203 ? 30.633 77.789 40.468 1.00 38.24 ? 269 ILE A CD1 1 ATOM 1552 N N . GLN A 1 204 ? 30.311 78.185 35.542 1.00 39.99 ? 270 GLN A N 1 ATOM 1553 C CA . GLN A 1 204 ? 31.353 78.863 34.792 1.00 39.77 ? 270 GLN A CA 1 ATOM 1554 C C . GLN A 1 204 ? 32.364 79.433 35.799 1.00 44.49 ? 270 GLN A C 1 ATOM 1555 O O . GLN A 1 204 ? 31.983 79.933 36.869 1.00 42.87 ? 270 GLN A O 1 ATOM 1556 C CB . GLN A 1 204 ? 30.733 79.999 33.950 1.00 41.61 ? 270 GLN A CB 1 ATOM 1557 C CG . GLN A 1 204 ? 31.680 80.668 32.932 1.00 49.78 ? 270 GLN A CG 1 ATOM 1558 C CD . GLN A 1 204 ? 32.055 79.786 31.768 1.00 64.21 ? 270 GLN A CD 1 ATOM 1559 O OE1 . GLN A 1 204 ? 31.207 79.129 31.153 1.00 65.35 ? 270 GLN A OE1 1 ATOM 1560 N NE2 . GLN A 1 204 ? 33.328 79.811 31.398 1.00 55.12 ? 270 GLN A NE2 1 ATOM 1561 N N . MET A 1 205 ? 33.652 79.312 35.463 1.00 42.05 ? 271 MET A N 1 ATOM 1562 C CA . MET A 1 205 ? 34.736 79.880 36.243 1.00 42.54 ? 271 MET A CA 1 ATOM 1563 C C . MET A 1 205 ? 35.436 80.898 35.315 1.00 49.59 ? 271 MET A C 1 ATOM 1564 O O . MET A 1 205 ? 35.800 80.562 34.180 1.00 49.02 ? 271 MET A O 1 ATOM 1565 C CB . MET A 1 205 ? 35.688 78.792 36.785 1.00 44.29 ? 271 MET A CB 1 ATOM 1566 C CG . MET A 1 205 ? 36.835 79.353 37.621 1.00 47.07 ? 271 MET A CG 1 ATOM 1567 S SD . MET A 1 205 ? 37.430 78.266 38.938 1.00 50.24 ? 271 MET A SD 1 ATOM 1568 C CE . MET A 1 205 ? 37.981 76.914 38.022 1.00 45.90 ? 271 MET A CE 1 ATOM 1569 N N . LYS A 1 206 ? 35.572 82.143 35.795 1.00 47.60 ? 272 LYS A N 1 ATOM 1570 C CA . LYS A 1 206 ? 36.132 83.257 35.034 1.00 47.94 ? 272 LYS A CA 1 ATOM 1571 C C . LYS A 1 206 ? 37.657 83.304 34.994 1.00 51.38 ? 272 LYS A C 1 ATOM 1572 O O . LYS A 1 206 ? 38.202 83.915 34.076 1.00 52.93 ? 272 LYS A O 1 ATOM 1573 C CB . LYS A 1 206 ? 35.558 84.597 35.535 1.00 50.57 ? 272 LYS A CB 1 ATOM 1574 C CG . LYS A 1 206 ? 34.068 84.799 35.230 1.00 53.28 ? 272 LYS A CG 1 ATOM 1575 C CD . LYS A 1 206 ? 33.398 85.617 36.335 1.00 61.77 ? 272 LYS A CD 1 ATOM 1576 C CE . LYS A 1 206 ? 32.532 86.746 35.825 1.00 69.78 ? 272 LYS A CE 1 ATOM 1577 N NZ . LYS A 1 206 ? 32.766 88.013 36.581 1.00 74.27 ? 272 LYS A NZ 1 ATOM 1578 N N . GLY A 1 207 ? 38.325 82.658 35.953 1.00 46.13 ? 273 GLY A N 1 ATOM 1579 C CA . GLY A 1 207 ? 39.786 82.626 36.033 1.00 44.65 ? 273 GLY A CA 1 ATOM 1580 C C . GLY A 1 207 ? 40.351 82.110 37.342 1.00 46.65 ? 273 GLY A C 1 ATOM 1581 O O . GLY A 1 207 ? 39.664 82.134 38.360 1.00 46.84 ? 273 GLY A O 1 ATOM 1582 N N . VAL A 1 208 ? 41.606 81.620 37.321 1.00 42.13 ? 274 VAL A N 1 ATOM 1583 C CA . VAL A 1 208 ? 42.324 81.093 38.490 1.00 41.17 ? 274 VAL A CA 1 ATOM 1584 C C . VAL A 1 208 ? 43.639 81.880 38.664 1.00 50.46 ? 274 VAL A C 1 ATOM 1585 O O . VAL A 1 208 ? 44.448 81.930 37.744 1.00 50.34 ? 274 VAL A O 1 ATOM 1586 C CB . VAL A 1 208 ? 42.557 79.544 38.426 1.00 41.82 ? 274 VAL A CB 1 ATOM 1587 C CG1 . VAL A 1 208 ? 43.274 79.032 39.672 1.00 40.36 ? 274 VAL A CG1 1 ATOM 1588 C CG2 . VAL A 1 208 ? 41.248 78.791 38.231 1.00 41.03 ? 274 VAL A CG2 1 ATOM 1589 N N . SER A 1 209 ? 43.844 82.478 39.848 1.00 51.37 ? 275 SER A N 1 ATOM 1590 C CA . SER A 1 209 ? 45.044 83.267 40.181 1.00 52.68 ? 275 SER A CA 1 ATOM 1591 C C . SER A 1 209 ? 45.945 82.584 41.209 1.00 57.98 ? 275 SER A C 1 ATOM 1592 O O . SER A 1 209 ? 45.460 82.095 42.223 1.00 58.07 ? 275 SER A O 1 ATOM 1593 C CB . SER A 1 209 ? 44.658 84.645 40.718 1.00 57.06 ? 275 SER A CB 1 ATOM 1594 O OG . SER A 1 209 ? 43.711 85.291 39.879 1.00 73.10 ? 275 SER A OG 1 ATOM 1595 N N . VAL A 1 210 ? 47.258 82.577 40.954 1.00 55.47 ? 276 VAL A N 1 ATOM 1596 C CA . VAL A 1 210 ? 48.270 82.025 41.858 1.00 56.12 ? 276 VAL A CA 1 ATOM 1597 C C . VAL A 1 210 ? 49.172 83.187 42.213 1.00 65.39 ? 276 VAL A C 1 ATOM 1598 O O . VAL A 1 210 ? 49.947 83.630 41.359 1.00 65.68 ? 276 VAL A O 1 ATOM 1599 C CB . VAL A 1 210 ? 49.067 80.844 41.257 1.00 59.20 ? 276 VAL A CB 1 ATOM 1600 C CG1 . VAL A 1 210 ? 49.954 80.172 42.314 1.00 58.61 ? 276 VAL A CG1 1 ATOM 1601 C CG2 . VAL A 1 210 ? 48.139 79.849 40.582 1.00 58.85 ? 276 VAL A CG2 1 ATOM 1602 N N . GLY A 1 211 ? 49.014 83.702 43.438 1.00 65.49 ? 277 GLY A N 1 ATOM 1603 C CA . GLY A 1 211 ? 49.746 84.855 43.938 1.00 67.04 ? 277 GLY A CA 1 ATOM 1604 C C . GLY A 1 211 ? 49.472 86.088 43.104 1.00 75.04 ? 277 GLY A C 1 ATOM 1605 O O . GLY A 1 211 ? 48.317 86.500 42.929 1.00 75.78 ? 277 GLY A O 1 ATOM 1606 N N . SER A 1 212 ? 50.554 86.657 42.549 1.00 73.25 ? 278 SER A N 1 ATOM 1607 C CA . SER A 1 212 ? 50.486 87.876 41.736 1.00 74.29 ? 278 SER A CA 1 ATOM 1608 C C . SER A 1 212 ? 50.760 87.637 40.255 1.00 80.47 ? 278 SER A C 1 ATOM 1609 O O . SER A 1 212 ? 49.907 87.934 39.411 1.00 80.26 ? 278 SER A O 1 ATOM 1610 C CB . SER A 1 212 ? 51.435 88.946 42.279 1.00 77.86 ? 278 SER A CB 1 ATOM 1611 O OG . SER A 1 212 ? 52.735 88.414 42.481 1.00 87.15 ? 278 SER A OG 1 ATOM 1612 N N . SER A 1 213 ? 51.982 87.143 39.939 1.00 78.04 ? 279 SER A N 1 ATOM 1613 C CA . SER A 1 213 ? 52.509 86.952 38.581 1.00 77.78 ? 279 SER A CA 1 ATOM 1614 C C . SER A 1 213 ? 52.037 85.681 37.823 1.00 80.27 ? 279 SER A C 1 ATOM 1615 O O . SER A 1 213 ? 52.399 85.548 36.649 1.00 80.78 ? 279 SER A O 1 ATOM 1616 C CB . SER A 1 213 ? 54.039 87.025 38.579 1.00 81.07 ? 279 SER A CB 1 ATOM 1617 O OG . SER A 1 213 ? 54.641 86.273 39.621 1.00 89.54 ? 279 SER A OG 1 ATOM 1618 N N . THR A 1 214 ? 51.224 84.783 38.441 1.00 74.14 ? 280 THR A N 1 ATOM 1619 C CA . THR A 1 214 ? 50.731 83.583 37.735 1.00 72.77 ? 280 THR A CA 1 ATOM 1620 C C . THR A 1 214 ? 49.200 83.663 37.474 1.00 73.92 ? 280 THR A C 1 ATOM 1621 O O . THR A 1 214 ? 48.443 84.173 38.315 1.00 73.50 ? 280 THR A O 1 ATOM 1622 C CB . THR A 1 214 ? 51.173 82.271 38.434 1.00 79.71 ? 280 THR A CB 1 ATOM 1623 O OG1 . THR A 1 214 ? 52.560 82.352 38.785 1.00 81.99 ? 280 THR A OG1 1 ATOM 1624 C CG2 . THR A 1 214 ? 50.930 81.019 37.573 1.00 74.59 ? 280 THR A CG2 1 ATOM 1625 N N . LEU A 1 215 ? 48.767 83.177 36.283 1.00 67.01 ? 281 LEU A N 1 ATOM 1626 C CA . LEU A 1 215 ? 47.366 83.154 35.858 1.00 64.86 ? 281 LEU A CA 1 ATOM 1627 C C . LEU A 1 215 ? 47.045 81.936 35.000 1.00 66.17 ? 281 LEU A C 1 ATOM 1628 O O . LEU A 1 215 ? 47.844 81.519 34.152 1.00 66.61 ? 281 LEU A O 1 ATOM 1629 C CB . LEU A 1 215 ? 46.974 84.441 35.127 1.00 64.54 ? 281 LEU A CB 1 ATOM 1630 C CG . LEU A 1 215 ? 45.864 85.238 35.778 1.00 68.99 ? 281 LEU A CG 1 ATOM 1631 C CD1 . LEU A 1 215 ? 46.242 86.692 35.881 1.00 68.88 ? 281 LEU A CD1 1 ATOM 1632 C CD2 . LEU A 1 215 ? 44.520 85.036 35.050 1.00 70.84 ? 281 LEU A CD2 1 ATOM 1633 N N . LEU A 1 216 ? 45.869 81.353 35.259 1.00 59.41 ? 282 LEU A N 1 ATOM 1634 C CA . LEU A 1 216 ? 45.306 80.176 34.592 1.00 57.29 ? 282 LEU A CA 1 ATOM 1635 C C . LEU A 1 216 ? 43.834 80.450 34.367 1.00 57.22 ? 282 LEU A C 1 ATOM 1636 O O . LEU A 1 216 ? 43.318 81.400 34.959 1.00 55.14 ? 282 LEU A O 1 ATOM 1637 C CB . LEU A 1 216 ? 45.486 78.947 35.493 1.00 57.05 ? 282 LEU A CB 1 ATOM 1638 C CG . LEU A 1 216 ? 46.919 78.466 35.647 1.00 60.91 ? 282 LEU A CG 1 ATOM 1639 C CD1 . LEU A 1 216 ? 47.305 78.370 37.086 1.00 60.76 ? 282 LEU A CD1 1 ATOM 1640 C CD2 . LEU A 1 216 ? 47.117 77.160 34.932 1.00 63.71 ? 282 LEU A CD2 1 ATOM 1641 N N . CYS A 1 217 ? 43.147 79.652 33.503 1.00 54.04 ? 283 CYS A N 1 ATOM 1642 C CA . CYS A 1 217 ? 41.712 79.839 33.187 1.00 53.74 ? 283 CYS A CA 1 ATOM 1643 C C . CYS A 1 217 ? 41.487 81.289 32.682 1.00 58.09 ? 283 CYS A C 1 ATOM 1644 O O . CYS A 1 217 ? 40.426 81.879 32.875 1.00 57.64 ? 283 CYS A O 1 ATOM 1645 C CB . CYS A 1 217 ? 40.858 79.513 34.415 1.00 53.99 ? 283 CYS A CB 1 ATOM 1646 S SG . CYS A 1 217 ? 39.065 79.505 34.127 1.00 57.46 ? 283 CYS A SG 1 ATOM 1647 N N . GLU A 1 218 ? 42.514 81.844 32.009 1.00 56.64 ? 284 GLU A N 1 ATOM 1648 C CA . GLU A 1 218 ? 42.563 83.207 31.483 1.00 57.04 ? 284 GLU A CA 1 ATOM 1649 C C . GLU A 1 218 ? 41.399 83.517 30.545 1.00 61.81 ? 284 GLU A C 1 ATOM 1650 O O . GLU A 1 218 ? 40.865 84.625 30.603 1.00 62.11 ? 284 GLU A O 1 ATOM 1651 C CB . GLU A 1 218 ? 43.923 83.481 30.821 1.00 58.83 ? 284 GLU A CB 1 ATOM 1652 C CG . GLU A 1 218 ? 45.124 83.214 31.722 1.00 72.38 ? 284 GLU A CG 1 ATOM 1653 C CD . GLU A 1 218 ? 46.466 83.160 31.015 1.00 96.45 ? 284 GLU A CD 1 ATOM 1654 O OE1 . GLU A 1 218 ? 46.958 84.231 30.590 1.00 96.54 ? 284 GLU A OE1 1 ATOM 1655 O OE2 . GLU A 1 218 ? 47.039 82.052 30.906 1.00 88.94 ? 284 GLU A OE2 1 ATOM 1656 N N . ASP A 1 219 ? 40.955 82.521 29.745 1.00 58.58 ? 285 ASP A N 1 ATOM 1657 C CA . ASP A 1 219 ? 39.832 82.684 28.814 1.00 59.13 ? 285 ASP A CA 1 ATOM 1658 C C . ASP A 1 219 ? 38.515 82.008 29.294 1.00 61.31 ? 285 ASP A C 1 ATOM 1659 O O . ASP A 1 219 ? 37.582 81.854 28.500 1.00 60.05 ? 285 ASP A O 1 ATOM 1660 C CB . ASP A 1 219 ? 40.230 82.220 27.387 1.00 62.00 ? 285 ASP A CB 1 ATOM 1661 C CG . ASP A 1 219 ? 41.359 83.016 26.749 1.00 77.41 ? 285 ASP A CG 1 ATOM 1662 O OD1 . ASP A 1 219 ? 41.306 84.276 26.794 1.00 79.29 ? 285 ASP A OD1 1 ATOM 1663 O OD2 . ASP A 1 219 ? 42.284 82.387 26.190 1.00 83.83 ? 285 ASP A OD2 1 ATOM 1664 N N . GLY A 1 220 ? 38.448 81.636 30.581 1.00 57.17 ? 286 GLY A N 1 ATOM 1665 C CA . GLY A 1 220 ? 37.270 80.994 31.159 1.00 56.31 ? 286 GLY A CA 1 ATOM 1666 C C . GLY A 1 220 ? 37.312 79.479 31.122 1.00 58.70 ? 286 GLY A C 1 ATOM 1667 O O . GLY A 1 220 ? 37.911 78.869 30.224 1.00 56.90 ? 286 GLY A O 1 ATOM 1668 N N . CYS A 1 221 ? 36.685 78.860 32.120 1.00 54.58 ? 287 CYS A N 1 ATOM 1669 C CA . CYS A 1 221 ? 36.671 77.408 32.240 1.00 53.15 ? 287 CYS A CA 1 ATOM 1670 C C . CYS A 1 221 ? 35.463 76.931 33.034 1.00 53.45 ? 287 CYS A C 1 ATOM 1671 O O . CYS A 1 221 ? 34.547 77.719 33.312 1.00 52.72 ? 287 CYS A O 1 ATOM 1672 C CB . CYS A 1 221 ? 37.991 76.895 32.818 1.00 53.50 ? 287 CYS A CB 1 ATOM 1673 S SG . CYS A 1 221 ? 38.424 77.595 34.433 1.00 57.64 ? 287 CYS A SG 1 ATOM 1674 N N . LEU A 1 222 ? 35.415 75.626 33.326 1.00 47.16 ? 288 LEU A N 1 ATOM 1675 C CA . LEU A 1 222 ? 34.306 75.052 34.076 1.00 44.94 ? 288 LEU A CA 1 ATOM 1676 C C . LEU A 1 222 ? 34.765 74.625 35.449 1.00 43.57 ? 288 LEU A C 1 ATOM 1677 O O . LEU A 1 222 ? 35.937 74.310 35.659 1.00 39.96 ? 288 LEU A O 1 ATOM 1678 C CB . LEU A 1 222 ? 33.669 73.859 33.339 1.00 44.72 ? 288 LEU A CB 1 ATOM 1679 C CG . LEU A 1 222 ? 33.259 74.048 31.875 1.00 48.06 ? 288 LEU A CG 1 ATOM 1680 C CD1 . LEU A 1 222 ? 32.639 72.787 31.344 1.00 46.82 ? 288 LEU A CD1 1 ATOM 1681 C CD2 . LEU A 1 222 ? 32.283 75.212 31.718 1.00 50.45 ? 288 LEU A CD2 1 ATOM 1682 N N . ALA A 1 223 ? 33.823 74.627 36.393 1.00 40.00 ? 289 ALA A N 1 ATOM 1683 C CA . ALA A 1 223 ? 34.085 74.185 37.749 1.00 38.80 ? 289 ALA A CA 1 ATOM 1684 C C . ALA A 1 223 ? 32.924 73.321 38.223 1.00 40.73 ? 289 ALA A C 1 ATOM 1685 O O . ALA A 1 223 ? 31.784 73.783 38.313 1.00 39.84 ? 289 ALA A O 1 ATOM 1686 C CB . ALA A 1 223 ? 34.329 75.385 38.683 1.00 38.93 ? 289 ALA A CB 1 ATOM 1687 N N . LEU A 1 224 ? 33.205 72.041 38.454 1.00 38.24 ? 290 LEU A N 1 ATOM 1688 C CA . LEU A 1 224 ? 32.227 71.107 39.009 1.00 38.95 ? 290 LEU A CA 1 ATOM 1689 C C . LEU A 1 224 ? 32.292 71.252 40.539 1.00 41.35 ? 290 LEU A C 1 ATOM 1690 O O . LEU A 1 224 ? 33.390 71.299 41.096 1.00 41.62 ? 290 LEU A O 1 ATOM 1691 C CB . LEU A 1 224 ? 32.544 69.668 38.561 1.00 40.09 ? 290 LEU A CB 1 ATOM 1692 C CG . LEU A 1 224 ? 31.629 68.551 39.103 1.00 46.76 ? 290 LEU A CG 1 ATOM 1693 C CD1 . LEU A 1 224 ? 30.247 68.587 38.459 1.00 46.41 ? 290 LEU A CD1 1 ATOM 1694 C CD2 . LEU A 1 224 ? 32.257 67.199 38.869 1.00 50.70 ? 290 LEU A CD2 1 ATOM 1695 N N . VAL A 1 225 ? 31.147 71.443 41.208 1.00 36.90 ? 291 VAL A N 1 ATOM 1696 C CA . VAL A 1 225 ? 31.142 71.580 42.668 1.00 36.12 ? 291 VAL A CA 1 ATOM 1697 C C . VAL A 1 225 ? 30.801 70.197 43.215 1.00 39.19 ? 291 VAL A C 1 ATOM 1698 O O . VAL A 1 225 ? 29.664 69.730 43.114 1.00 38.60 ? 291 VAL A O 1 ATOM 1699 C CB . VAL A 1 225 ? 30.294 72.769 43.191 1.00 39.37 ? 291 VAL A CB 1 ATOM 1700 C CG1 . VAL A 1 225 ? 30.472 72.929 44.695 1.00 38.99 ? 291 VAL A CG1 1 ATOM 1701 C CG2 . VAL A 1 225 ? 30.699 74.059 42.477 1.00 38.62 ? 291 VAL A CG2 1 ATOM 1702 N N . ASP A 1 226 ? 31.852 69.498 43.670 1.00 35.85 ? 292 ASP A N 1 ATOM 1703 C CA . ASP A 1 226 ? 31.843 68.067 43.993 1.00 34.93 ? 292 ASP A CA 1 ATOM 1704 C C . ASP A 1 226 ? 32.094 67.730 45.464 1.00 34.52 ? 292 ASP A C 1 ATOM 1705 O O . ASP A 1 226 ? 33.229 67.716 45.904 1.00 32.96 ? 292 ASP A O 1 ATOM 1706 C CB . ASP A 1 226 ? 32.873 67.367 43.071 1.00 36.84 ? 292 ASP A CB 1 ATOM 1707 C CG . ASP A 1 226 ? 32.793 65.865 42.971 1.00 48.20 ? 292 ASP A CG 1 ATOM 1708 O OD1 . ASP A 1 226 ? 31.973 65.263 43.695 1.00 51.00 ? 292 ASP A OD1 1 ATOM 1709 O OD2 . ASP A 1 226 ? 33.561 65.283 42.178 1.00 49.48 ? 292 ASP A OD2 1 ATOM 1710 N N . THR A 1 227 ? 31.029 67.358 46.183 1.00 31.39 ? 293 THR A N 1 ATOM 1711 C CA . THR A 1 227 ? 31.079 67.015 47.609 1.00 31.54 ? 293 THR A CA 1 ATOM 1712 C C . THR A 1 227 ? 31.765 65.656 47.869 1.00 34.99 ? 293 THR A C 1 ATOM 1713 O O . THR A 1 227 ? 32.251 65.427 48.976 1.00 33.70 ? 293 THR A O 1 ATOM 1714 C CB . THR A 1 227 ? 29.683 67.122 48.241 1.00 34.53 ? 293 THR A CB 1 ATOM 1715 O OG1 . THR A 1 227 ? 28.796 66.208 47.593 1.00 29.95 ? 293 THR A OG1 1 ATOM 1716 C CG2 . THR A 1 227 ? 29.115 68.542 48.148 1.00 31.43 ? 293 THR A CG2 1 ATOM 1717 N N . GLY A 1 228 ? 31.822 64.806 46.838 1.00 32.66 ? 294 GLY A N 1 ATOM 1718 C CA . GLY A 1 228 ? 32.457 63.491 46.901 1.00 32.38 ? 294 GLY A CA 1 ATOM 1719 C C . GLY A 1 228 ? 33.941 63.515 46.617 1.00 36.71 ? 294 GLY A C 1 ATOM 1720 O O . GLY A 1 228 ? 34.645 62.562 46.952 1.00 37.10 ? 294 GLY A O 1 ATOM 1721 N N . ALA A 1 229 ? 34.438 64.597 45.996 1.00 32.86 ? 295 ALA A N 1 ATOM 1722 C CA . ALA A 1 229 ? 35.862 64.730 45.702 1.00 31.29 ? 295 ALA A CA 1 ATOM 1723 C C . ALA A 1 229 ? 36.583 65.310 46.936 1.00 34.97 ? 295 ALA A C 1 ATOM 1724 O O . ALA A 1 229 ? 36.096 66.252 47.571 1.00 34.45 ? 295 ALA A O 1 ATOM 1725 C CB . ALA A 1 229 ? 36.060 65.627 44.495 1.00 31.37 ? 295 ALA A CB 1 ATOM 1726 N N . SER A 1 230 ? 37.720 64.731 47.287 1.00 31.79 ? 296 SER A N 1 ATOM 1727 C CA . SER A 1 230 ? 38.533 65.141 48.427 1.00 32.12 ? 296 SER A CA 1 ATOM 1728 C C . SER A 1 230 ? 39.240 66.455 48.193 1.00 37.00 ? 296 SER A C 1 ATOM 1729 O O . SER A 1 230 ? 39.424 67.233 49.130 1.00 37.72 ? 296 SER A O 1 ATOM 1730 C CB . SER A 1 230 ? 39.626 64.112 48.683 1.00 35.40 ? 296 SER A CB 1 ATOM 1731 O OG . SER A 1 230 ? 39.070 62.841 48.932 1.00 44.91 ? 296 SER A OG 1 ATOM 1732 N N . TYR A 1 231 ? 39.741 66.638 46.971 1.00 32.22 ? 297 TYR A N 1 ATOM 1733 C CA . TYR A 1 231 ? 40.606 67.749 46.652 1.00 32.95 ? 297 TYR A CA 1 ATOM 1734 C C . TYR A 1 231 ? 40.027 68.646 45.591 1.00 37.21 ? 297 TYR A C 1 ATOM 1735 O O . TYR A 1 231 ? 38.973 68.367 45.014 1.00 36.06 ? 297 TYR A O 1 ATOM 1736 C CB . TYR A 1 231 ? 41.984 67.188 46.168 1.00 34.88 ? 297 TYR A CB 1 ATOM 1737 C CG . TYR A 1 231 ? 42.532 66.048 47.006 1.00 37.41 ? 297 TYR A CG 1 ATOM 1738 C CD1 . TYR A 1 231 ? 43.034 66.273 48.288 1.00 37.69 ? 297 TYR A CD1 1 ATOM 1739 C CD2 . TYR A 1 231 ? 42.488 64.733 46.545 1.00 40.38 ? 297 TYR A CD2 1 ATOM 1740 C CE1 . TYR A 1 231 ? 43.519 65.223 49.073 1.00 37.36 ? 297 TYR A CE1 1 ATOM 1741 C CE2 . TYR A 1 231 ? 42.957 63.669 47.330 1.00 41.81 ? 297 TYR A CE2 1 ATOM 1742 C CZ . TYR A 1 231 ? 43.468 63.921 48.593 1.00 47.27 ? 297 TYR A CZ 1 ATOM 1743 O OH . TYR A 1 231 ? 43.904 62.870 49.359 1.00 50.84 ? 297 TYR A OH 1 ATOM 1744 N N . ILE A 1 232 ? 40.741 69.733 45.331 1.00 34.59 ? 298 ILE A N 1 ATOM 1745 C CA . ILE A 1 232 ? 40.459 70.609 44.217 1.00 35.10 ? 298 ILE A CA 1 ATOM 1746 C C . ILE A 1 232 ? 41.225 69.943 43.061 1.00 37.54 ? 298 ILE A C 1 ATOM 1747 O O . ILE A 1 232 ? 42.357 69.493 43.248 1.00 35.21 ? 298 ILE A O 1 ATOM 1748 C CB . ILE A 1 232 ? 40.929 72.076 44.490 1.00 38.00 ? 298 ILE A CB 1 ATOM 1749 C CG1 . ILE A 1 232 ? 39.894 72.801 45.397 1.00 37.33 ? 298 ILE A CG1 1 ATOM 1750 C CG2 . ILE A 1 232 ? 41.165 72.839 43.160 1.00 38.61 ? 298 ILE A CG2 1 ATOM 1751 C CD1 . ILE A 1 232 ? 40.305 74.152 45.889 1.00 42.05 ? 298 ILE A CD1 1 ATOM 1752 N N . SER A 1 233 ? 40.586 69.809 41.910 1.00 34.90 ? 299 SER A N 1 ATOM 1753 C CA . SER A 1 233 ? 41.263 69.254 40.751 1.00 35.04 ? 299 SER A CA 1 ATOM 1754 C C . SER A 1 233 ? 41.134 70.128 39.514 1.00 43.21 ? 299 SER A C 1 ATOM 1755 O O . SER A 1 233 ? 40.154 70.855 39.352 1.00 43.55 ? 299 SER A O 1 ATOM 1756 C CB . SER A 1 233 ? 40.827 67.823 40.475 1.00 35.02 ? 299 SER A CB 1 ATOM 1757 O OG . SER A 1 233 ? 39.571 67.760 39.839 1.00 38.93 ? 299 SER A OG 1 ATOM 1758 N N . GLY A 1 234 ? 42.158 70.062 38.686 1.00 42.32 ? 300 GLY A N 1 ATOM 1759 C CA . GLY A 1 234 ? 42.244 70.695 37.381 1.00 42.98 ? 300 GLY A CA 1 ATOM 1760 C C . GLY A 1 234 ? 42.819 69.688 36.410 1.00 48.79 ? 300 GLY A C 1 ATOM 1761 O O . GLY A 1 234 ? 43.238 68.597 36.820 1.00 47.98 ? 300 GLY A O 1 ATOM 1762 N N . SER A 1 235 ? 42.861 70.048 35.123 1.00 48.18 ? 301 SER A N 1 ATOM 1763 C CA . SER A 1 235 ? 43.436 69.207 34.063 1.00 48.40 ? 301 SER A CA 1 ATOM 1764 C C . SER A 1 235 ? 44.937 69.110 34.289 1.00 52.19 ? 301 SER A C 1 ATOM 1765 O O . SER A 1 235 ? 45.509 69.993 34.942 1.00 51.38 ? 301 SER A O 1 ATOM 1766 C CB . SER A 1 235 ? 43.168 69.829 32.695 1.00 51.56 ? 301 SER A CB 1 ATOM 1767 O OG . SER A 1 235 ? 43.914 71.025 32.515 1.00 56.71 ? 301 SER A OG 1 ATOM 1768 N N . THR A 1 236 ? 45.574 68.057 33.739 1.00 49.90 ? 302 THR A N 1 ATOM 1769 C CA . THR A 1 236 ? 47.019 67.820 33.867 1.00 49.96 ? 302 THR A CA 1 ATOM 1770 C C . THR A 1 236 ? 47.826 69.061 33.474 1.00 51.66 ? 302 THR A C 1 ATOM 1771 O O . THR A 1 236 ? 48.725 69.441 34.219 1.00 49.88 ? 302 THR A O 1 ATOM 1772 C CB . THR A 1 236 ? 47.439 66.542 33.115 1.00 59.38 ? 302 THR A CB 1 ATOM 1773 O OG1 . THR A 1 236 ? 46.675 65.458 33.629 1.00 62.30 ? 302 THR A OG1 1 ATOM 1774 C CG2 . THR A 1 236 ? 48.922 66.205 33.299 1.00 54.93 ? 302 THR A CG2 1 ATOM 1775 N N . SER A 1 237 ? 47.469 69.714 32.348 1.00 48.71 ? 303 SER A N 1 ATOM 1776 C CA . SER A 1 237 ? 48.161 70.918 31.875 1.00 49.05 ? 303 SER A CA 1 ATOM 1777 C C . SER A 1 237 ? 48.050 72.075 32.871 1.00 52.29 ? 303 SER A C 1 ATOM 1778 O O . SER A 1 237 ? 49.082 72.595 33.304 1.00 52.34 ? 303 SER A O 1 ATOM 1779 C CB . SER A 1 237 ? 47.691 71.316 30.477 1.00 53.23 ? 303 SER A CB 1 ATOM 1780 O OG . SER A 1 237 ? 46.278 71.294 30.351 1.00 63.96 ? 303 SER A OG 1 ATOM 1781 N N . SER A 1 238 ? 46.806 72.408 33.303 1.00 48.12 ? 304 SER A N 1 ATOM 1782 C CA . SER A 1 238 ? 46.522 73.462 34.288 1.00 46.84 ? 304 SER A CA 1 ATOM 1783 C C . SER A 1 238 ? 47.289 73.217 35.593 1.00 48.21 ? 304 SER A C 1 ATOM 1784 O O . SER A 1 238 ? 47.945 74.125 36.112 1.00 47.46 ? 304 SER A O 1 ATOM 1785 C CB . SER A 1 238 ? 45.027 73.530 34.587 1.00 51.52 ? 304 SER A CB 1 ATOM 1786 O OG . SER A 1 238 ? 44.257 73.752 33.419 1.00 64.78 ? 304 SER A OG 1 ATOM 1787 N N . ILE A 1 239 ? 47.241 71.976 36.087 1.00 44.59 ? 305 ILE A N 1 ATOM 1788 C CA . ILE A 1 239 ? 47.897 71.586 37.326 1.00 44.70 ? 305 ILE A CA 1 ATOM 1789 C C . ILE A 1 239 ? 49.420 71.599 37.165 1.00 50.70 ? 305 ILE A C 1 ATOM 1790 O O . ILE A 1 239 ? 50.097 71.981 38.116 1.00 51.48 ? 305 ILE A O 1 ATOM 1791 C CB . ILE A 1 239 ? 47.317 70.264 37.912 1.00 46.63 ? 305 ILE A CB 1 ATOM 1792 C CG1 . ILE A 1 239 ? 45.820 70.439 38.282 1.00 46.07 ? 305 ILE A CG1 1 ATOM 1793 C CG2 . ILE A 1 239 ? 48.105 69.741 39.123 1.00 46.23 ? 305 ILE A CG2 1 ATOM 1794 C CD1 . ILE A 1 239 ? 45.411 71.634 39.211 1.00 51.80 ? 305 ILE A CD1 1 ATOM 1795 N N . GLU A 1 240 ? 49.950 71.301 35.968 1.00 48.93 ? 306 GLU A N 1 ATOM 1796 C CA . GLU A 1 240 ? 51.398 71.395 35.719 1.00 49.33 ? 306 GLU A CA 1 ATOM 1797 C C . GLU A 1 240 ? 51.890 72.850 35.862 1.00 50.60 ? 306 GLU A C 1 ATOM 1798 O O . GLU A 1 240 ? 52.888 73.081 36.547 1.00 49.75 ? 306 GLU A O 1 ATOM 1799 C CB . GLU A 1 240 ? 51.786 70.795 34.357 1.00 50.99 ? 306 GLU A CB 1 ATOM 1800 C CG . GLU A 1 240 ? 52.065 69.304 34.436 1.00 65.88 ? 306 GLU A CG 1 ATOM 1801 C CD . GLU A 1 240 ? 51.988 68.510 33.139 1.00 96.92 ? 306 GLU A CD 1 ATOM 1802 O OE1 . GLU A 1 240 ? 51.718 69.107 32.069 1.00 89.52 ? 306 GLU A OE1 1 ATOM 1803 O OE2 . GLU A 1 240 ? 52.193 67.275 33.201 1.00 92.63 ? 306 GLU A OE2 1 ATOM 1804 N N . LYS A 1 241 ? 51.155 73.822 35.289 1.00 46.93 ? 307 LYS A N 1 ATOM 1805 C CA . LYS A 1 241 ? 51.519 75.246 35.396 1.00 48.29 ? 307 LYS A CA 1 ATOM 1806 C C . LYS A 1 241 ? 51.369 75.727 36.839 1.00 54.19 ? 307 LYS A C 1 ATOM 1807 O O . LYS A 1 241 ? 52.286 76.365 37.363 1.00 55.57 ? 307 LYS A O 1 ATOM 1808 C CB . LYS A 1 241 ? 50.692 76.147 34.457 1.00 50.90 ? 307 LYS A CB 1 ATOM 1809 C CG . LYS A 1 241 ? 50.602 75.668 33.021 1.00 66.18 ? 307 LYS A CG 1 ATOM 1810 C CD . LYS A 1 241 ? 49.748 76.587 32.171 1.00 79.63 ? 307 LYS A CD 1 ATOM 1811 C CE . LYS A 1 241 ? 49.709 76.096 30.735 1.00 92.62 ? 307 LYS A CE 1 ATOM 1812 N NZ . LYS A 1 241 ? 50.897 76.583 29.961 1.00 100.90 ? 307 LYS A NZ 1 ATOM 1813 N N . LEU A 1 242 ? 50.231 75.390 37.490 1.00 49.74 ? 308 LEU A N 1 ATOM 1814 C CA . LEU A 1 242 ? 49.954 75.742 38.887 1.00 48.34 ? 308 LEU A CA 1 ATOM 1815 C C . LEU A 1 242 ? 51.044 75.208 39.816 1.00 50.09 ? 308 LEU A C 1 ATOM 1816 O O . LEU A 1 242 ? 51.554 75.950 40.654 1.00 50.24 ? 308 LEU A O 1 ATOM 1817 C CB . LEU A 1 242 ? 48.547 75.256 39.315 1.00 48.38 ? 308 LEU A CB 1 ATOM 1818 C CG . LEU A 1 242 ? 48.211 75.293 40.826 1.00 53.04 ? 308 LEU A CG 1 ATOM 1819 C CD1 . LEU A 1 242 ? 47.479 76.496 41.183 1.00 53.16 ? 308 LEU A CD1 1 ATOM 1820 C CD2 . LEU A 1 242 ? 47.311 74.200 41.202 1.00 55.98 ? 308 LEU A CD2 1 ATOM 1821 N N . MET A 1 243 ? 51.433 73.944 39.642 1.00 44.59 ? 309 MET A N 1 ATOM 1822 C CA . MET A 1 243 ? 52.448 73.324 40.503 1.00 43.46 ? 309 MET A CA 1 ATOM 1823 C C . MET A 1 243 ? 53.854 73.864 40.284 1.00 50.02 ? 309 MET A C 1 ATOM 1824 O O . MET A 1 243 ? 54.621 73.951 41.240 1.00 49.69 ? 309 MET A O 1 ATOM 1825 C CB . MET A 1 243 ? 52.403 71.802 40.396 1.00 44.58 ? 309 MET A CB 1 ATOM 1826 C CG . MET A 1 243 ? 51.125 71.217 41.010 1.00 46.27 ? 309 MET A CG 1 ATOM 1827 S SD . MET A 1 243 ? 50.974 71.478 42.794 1.00 48.60 ? 309 MET A SD 1 ATOM 1828 C CE . MET A 1 243 ? 49.408 70.822 43.065 1.00 45.66 ? 309 MET A CE 1 ATOM 1829 N N . GLU A 1 244 ? 54.181 74.251 39.042 1.00 50.45 ? 310 GLU A N 1 ATOM 1830 C CA . GLU A 1 244 ? 55.458 74.868 38.689 1.00 51.84 ? 310 GLU A CA 1 ATOM 1831 C C . GLU A 1 244 ? 55.574 76.190 39.479 1.00 54.73 ? 310 GLU A C 1 ATOM 1832 O O . GLU A 1 244 ? 56.592 76.421 40.130 1.00 53.86 ? 310 GLU A O 1 ATOM 1833 C CB . GLU A 1 244 ? 55.530 75.115 37.169 1.00 53.72 ? 310 GLU A CB 1 ATOM 1834 C CG . GLU A 1 244 ? 56.886 75.613 36.687 1.00 68.65 ? 310 GLU A CG 1 ATOM 1835 C CD . GLU A 1 244 ? 56.898 76.264 35.314 1.00 100.73 ? 310 GLU A CD 1 ATOM 1836 O OE1 . GLU A 1 244 ? 55.844 76.786 34.876 1.00 90.10 ? 310 GLU A OE1 1 ATOM 1837 O OE2 . GLU A 1 244 ? 57.979 76.272 34.682 1.00 105.91 ? 310 GLU A OE2 1 ATOM 1838 N N . ALA A 1 245 ? 54.487 76.986 39.489 1.00 51.30 ? 311 ALA A N 1 ATOM 1839 C CA . ALA A 1 245 ? 54.353 78.254 40.213 1.00 51.75 ? 311 ALA A CA 1 ATOM 1840 C C . ALA A 1 245 ? 54.510 78.116 41.740 1.00 57.45 ? 311 ALA A C 1 ATOM 1841 O O . ALA A 1 245 ? 55.024 79.029 42.383 1.00 59.24 ? 311 ALA A O 1 ATOM 1842 C CB . ALA A 1 245 ? 53.017 78.899 39.875 1.00 52.62 ? 311 ALA A CB 1 ATOM 1843 N N . LEU A 1 246 ? 54.077 76.984 42.320 1.00 52.98 ? 312 LEU A N 1 ATOM 1844 C CA . LEU A 1 246 ? 54.199 76.737 43.755 1.00 52.04 ? 312 LEU A CA 1 ATOM 1845 C C . LEU A 1 246 ? 55.564 76.115 44.132 1.00 54.68 ? 312 LEU A C 1 ATOM 1846 O O . LEU A 1 246 ? 55.936 76.137 45.302 1.00 54.56 ? 312 LEU A O 1 ATOM 1847 C CB . LEU A 1 246 ? 53.035 75.851 44.271 1.00 52.27 ? 312 LEU A CB 1 ATOM 1848 C CG . LEU A 1 246 ? 51.591 76.306 43.997 1.00 57.21 ? 312 LEU A CG 1 ATOM 1849 C CD1 . LEU A 1 246 ? 50.617 75.183 44.251 1.00 56.90 ? 312 LEU A CD1 1 ATOM 1850 C CD2 . LEU A 1 246 ? 51.208 77.500 44.834 1.00 61.06 ? 312 LEU A CD2 1 ATOM 1851 N N . GLY A 1 247 ? 56.287 75.573 43.152 1.00 49.81 ? 313 GLY A N 1 ATOM 1852 C CA . GLY A 1 247 ? 57.573 74.920 43.374 1.00 48.40 ? 313 GLY A CA 1 ATOM 1853 C C . GLY A 1 247 ? 57.402 73.507 43.892 1.00 51.87 ? 313 GLY A C 1 ATOM 1854 O O . GLY A 1 247 ? 58.300 72.955 44.533 1.00 50.74 ? 313 GLY A O 1 ATOM 1855 N N . ALA A 1 248 ? 56.232 72.907 43.600 1.00 49.60 ? 314 ALA A N 1 ATOM 1856 C CA . ALA A 1 248 ? 55.851 71.558 44.024 1.00 48.33 ? 314 ALA A CA 1 ATOM 1857 C C . ALA A 1 248 ? 56.352 70.516 43.043 1.00 50.88 ? 314 ALA A C 1 ATOM 1858 O O . ALA A 1 248 ? 56.374 70.766 41.833 1.00 50.45 ? 314 ALA A O 1 ATOM 1859 C CB . ALA A 1 248 ? 54.337 71.461 44.177 1.00 48.62 ? 314 ALA A CB 1 ATOM 1860 N N . LYS A 1 249 ? 56.748 69.348 43.578 1.00 46.34 ? 315 LYS A N 1 ATOM 1861 C CA . LYS A 1 249 ? 57.260 68.208 42.831 1.00 45.65 ? 315 LYS A CA 1 ATOM 1862 C C . LYS A 1 249 ? 56.208 67.107 42.763 1.00 47.81 ? 315 LYS A C 1 ATOM 1863 O O . LYS A 1 249 ? 55.539 66.808 43.758 1.00 47.58 ? 315 LYS A O 1 ATOM 1864 C CB . LYS A 1 249 ? 58.553 67.689 43.463 1.00 46.13 ? 315 LYS A CB 1 ATOM 1865 N N . LYS A 1 250 ? 56.035 66.562 41.556 1.00 44.55 ? 316 LYS A N 1 ATOM 1866 C CA . LYS A 1 250 ? 55.065 65.531 41.206 1.00 44.39 ? 316 LYS A CA 1 ATOM 1867 C C . LYS A 1 250 ? 55.487 64.146 41.660 1.00 49.02 ? 316 LYS A C 1 ATOM 1868 O O . LYS A 1 250 ? 56.647 63.749 41.502 1.00 49.80 ? 316 LYS A O 1 ATOM 1869 C CB . LYS A 1 250 ? 54.814 65.514 39.683 1.00 46.53 ? 316 LYS A CB 1 ATOM 1870 C CG . LYS A 1 250 ? 53.540 64.766 39.267 1.00 61.68 ? 316 LYS A CG 1 ATOM 1871 C CD . LYS A 1 250 ? 53.492 64.395 37.784 1.00 68.74 ? 316 LYS A CD 1 ATOM 1872 C CE . LYS A 1 250 ? 53.936 62.963 37.508 1.00 83.98 ? 316 LYS A CE 1 ATOM 1873 N NZ . LYS A 1 250 ? 52.957 61.940 37.982 1.00 84.36 ? 316 LYS A NZ 1 ATOM 1874 N N . ARG A 1 251 ? 54.532 63.413 42.222 1.00 43.94 ? 317 ARG A N 1 ATOM 1875 C CA . ARG A 1 251 ? 54.713 62.019 42.594 1.00 43.13 ? 317 ARG A CA 1 ATOM 1876 C C . ARG A 1 251 ? 53.653 61.230 41.792 1.00 48.90 ? 317 ARG A C 1 ATOM 1877 O O . ARG A 1 251 ? 53.008 61.796 40.881 1.00 47.73 ? 317 ARG A O 1 ATOM 1878 C CB . ARG A 1 251 ? 54.587 61.805 44.100 1.00 39.78 ? 317 ARG A CB 1 ATOM 1879 C CG . ARG A 1 251 ? 55.671 62.506 44.920 1.00 46.13 ? 317 ARG A CG 1 ATOM 1880 C CD . ARG A 1 251 ? 55.749 61.988 46.351 1.00 47.62 ? 317 ARG A CD 1 ATOM 1881 N NE . ARG A 1 251 ? 54.484 62.146 47.076 1.00 52.38 ? 317 ARG A NE 1 ATOM 1882 C CZ . ARG A 1 251 ? 54.311 61.887 48.373 1.00 65.41 ? 317 ARG A CZ 1 ATOM 1883 N NH1 . ARG A 1 251 ? 55.335 61.496 49.124 1.00 48.62 ? 317 ARG A NH1 1 ATOM 1884 N NH2 . ARG A 1 251 ? 53.121 62.056 48.936 1.00 49.92 ? 317 ARG A NH2 1 ATOM 1885 N N . LEU A 1 252 ? 53.484 59.940 42.122 1.00 46.27 ? 318 LEU A N 1 ATOM 1886 C CA . LEU A 1 252 ? 52.549 59.032 41.457 1.00 45.25 ? 318 LEU A CA 1 ATOM 1887 C C . LEU A 1 252 ? 51.086 59.520 41.451 1.00 48.19 ? 318 LEU A C 1 ATOM 1888 O O . LEU A 1 252 ? 50.494 59.658 40.380 1.00 47.20 ? 318 LEU A O 1 ATOM 1889 C CB . LEU A 1 252 ? 52.670 57.628 42.081 1.00 44.72 ? 318 LEU A CB 1 ATOM 1890 C CG . LEU A 1 252 ? 52.144 56.445 41.244 1.00 48.45 ? 318 LEU A CG 1 ATOM 1891 C CD1 . LEU A 1 252 ? 52.689 56.472 39.809 1.00 47.63 ? 318 LEU A CD1 1 ATOM 1892 C CD2 . LEU A 1 252 ? 52.484 55.144 41.914 1.00 48.97 ? 318 LEU A CD2 1 ATOM 1893 N N . PHE A 1 253 ? 50.526 59.816 42.643 1.00 44.62 ? 319 PHE A N 1 ATOM 1894 C CA . PHE A 1 253 ? 49.131 60.250 42.779 1.00 42.76 ? 319 PHE A CA 1 ATOM 1895 C C . PHE A 1 253 ? 48.941 61.667 43.302 1.00 45.59 ? 319 PHE A C 1 ATOM 1896 O O . PHE A 1 253 ? 47.803 62.102 43.456 1.00 46.53 ? 319 PHE A O 1 ATOM 1897 C CB . PHE A 1 253 ? 48.370 59.251 43.671 1.00 43.57 ? 319 PHE A CB 1 ATOM 1898 C CG . PHE A 1 253 ? 48.415 57.828 43.163 1.00 44.09 ? 319 PHE A CG 1 ATOM 1899 C CD1 . PHE A 1 253 ? 47.770 57.472 41.974 1.00 44.68 ? 319 PHE A CD1 1 ATOM 1900 C CD2 . PHE A 1 253 ? 49.099 56.839 43.871 1.00 44.05 ? 319 PHE A CD2 1 ATOM 1901 C CE1 . PHE A 1 253 ? 47.811 56.156 41.506 1.00 44.49 ? 319 PHE A CE1 1 ATOM 1902 C CE2 . PHE A 1 253 ? 49.127 55.521 43.403 1.00 45.39 ? 319 PHE A CE2 1 ATOM 1903 C CZ . PHE A 1 253 ? 48.469 55.189 42.234 1.00 43.14 ? 319 PHE A CZ 1 ATOM 1904 N N . ASP A 1 254 ? 50.022 62.386 43.594 1.00 42.86 ? 320 ASP A N 1 ATOM 1905 C CA . ASP A 1 254 ? 49.912 63.728 44.195 1.00 43.35 ? 320 ASP A CA 1 ATOM 1906 C C . ASP A 1 254 ? 51.130 64.628 43.956 1.00 45.14 ? 320 ASP A C 1 ATOM 1907 O O . ASP A 1 254 ? 52.106 64.195 43.344 1.00 43.85 ? 320 ASP A O 1 ATOM 1908 C CB . ASP A 1 254 ? 49.661 63.588 45.733 1.00 44.85 ? 320 ASP A CB 1 ATOM 1909 C CG . ASP A 1 254 ? 50.826 63.067 46.554 1.00 52.51 ? 320 ASP A CG 1 ATOM 1910 O OD1 . ASP A 1 254 ? 51.874 62.735 45.963 1.00 54.97 ? 320 ASP A OD1 1 ATOM 1911 O OD2 . ASP A 1 254 ? 50.682 62.965 47.778 1.00 58.30 ? 320 ASP A OD2 1 ATOM 1912 N N . TYR A 1 255 ? 51.092 65.848 44.536 1.00 40.71 ? 321 TYR A N 1 ATOM 1913 C CA . TYR A 1 255 ? 52.187 66.811 44.520 1.00 39.92 ? 321 TYR A CA 1 ATOM 1914 C C . TYR A 1 255 ? 52.599 67.113 45.935 1.00 43.91 ? 321 TYR A C 1 ATOM 1915 O O . TYR A 1 255 ? 51.764 67.113 46.833 1.00 42.55 ? 321 TYR A O 1 ATOM 1916 C CB . TYR A 1 255 ? 51.781 68.097 43.833 1.00 40.08 ? 321 TYR A CB 1 ATOM 1917 C CG . TYR A 1 255 ? 51.713 67.955 42.341 1.00 41.12 ? 321 TYR A CG 1 ATOM 1918 C CD1 . TYR A 1 255 ? 50.552 67.516 41.717 1.00 42.32 ? 321 TYR A CD1 1 ATOM 1919 C CD2 . TYR A 1 255 ? 52.789 68.322 41.538 1.00 42.98 ? 321 TYR A CD2 1 ATOM 1920 C CE1 . TYR A 1 255 ? 50.471 67.407 40.330 1.00 44.60 ? 321 TYR A CE1 1 ATOM 1921 C CE2 . TYR A 1 255 ? 52.718 68.232 40.145 1.00 44.55 ? 321 TYR A CE2 1 ATOM 1922 C CZ . TYR A 1 255 ? 51.560 67.760 39.545 1.00 52.36 ? 321 TYR A CZ 1 ATOM 1923 O OH . TYR A 1 255 ? 51.486 67.636 38.178 1.00 54.50 ? 321 TYR A OH 1 ATOM 1924 N N . VAL A 1 256 ? 53.894 67.368 46.136 1.00 40.96 ? 322 VAL A N 1 ATOM 1925 C CA . VAL A 1 256 ? 54.419 67.669 47.469 1.00 39.39 ? 322 VAL A CA 1 ATOM 1926 C C . VAL A 1 256 ? 55.326 68.885 47.444 1.00 42.43 ? 322 VAL A C 1 ATOM 1927 O O . VAL A 1 256 ? 55.848 69.254 46.385 1.00 42.41 ? 322 VAL A O 1 ATOM 1928 C CB . VAL A 1 256 ? 55.141 66.454 48.128 1.00 42.40 ? 322 VAL A CB 1 ATOM 1929 C CG1 . VAL A 1 256 ? 54.167 65.349 48.493 1.00 41.12 ? 322 VAL A CG1 1 ATOM 1930 C CG2 . VAL A 1 256 ? 56.276 65.918 47.249 1.00 42.20 ? 322 VAL A CG2 1 ATOM 1931 N N . VAL A 1 257 ? 55.536 69.483 48.622 1.00 38.32 ? 323 VAL A N 1 ATOM 1932 C CA . VAL A 1 257 ? 56.476 70.572 48.880 1.00 37.62 ? 323 VAL A CA 1 ATOM 1933 C C . VAL A 1 257 ? 57.246 70.181 50.123 1.00 42.91 ? 323 VAL A C 1 ATOM 1934 O O . VAL A 1 257 ? 56.747 69.377 50.913 1.00 42.43 ? 323 VAL A O 1 ATOM 1935 C CB . VAL A 1 257 ? 55.848 71.995 49.024 1.00 41.39 ? 323 VAL A CB 1 ATOM 1936 C CG1 . VAL A 1 257 ? 55.273 72.490 47.714 1.00 40.56 ? 323 VAL A CG1 1 ATOM 1937 C CG2 . VAL A 1 257 ? 54.813 72.069 50.155 1.00 41.71 ? 323 VAL A CG2 1 ATOM 1938 N N . LYS A 1 258 ? 58.435 70.773 50.328 1.00 41.71 ? 324 LYS A N 1 ATOM 1939 C CA . LYS A 1 258 ? 59.202 70.563 51.555 1.00 42.18 ? 324 LYS A CA 1 ATOM 1940 C C . LYS A 1 258 ? 58.324 71.192 52.643 1.00 45.54 ? 324 LYS A C 1 ATOM 1941 O O . LYS A 1 258 ? 57.828 72.302 52.427 1.00 45.38 ? 324 LYS A O 1 ATOM 1942 C CB . LYS A 1 258 ? 60.552 71.293 51.459 1.00 45.75 ? 324 LYS A CB 1 ATOM 1943 C CG . LYS A 1 258 ? 61.564 70.618 50.540 1.00 71.71 ? 324 LYS A CG 1 ATOM 1944 C CD . LYS A 1 258 ? 62.973 70.684 51.103 1.00 91.03 ? 324 LYS A CD 1 ATOM 1945 C CE . LYS A 1 258 ? 63.884 69.743 50.358 1.00 110.57 ? 324 LYS A CE 1 ATOM 1946 N NZ . LYS A 1 258 ? 63.802 68.359 50.903 1.00 122.73 ? 324 LYS A NZ 1 ATOM 1947 N N . CYS A 1 259 ? 58.049 70.472 53.748 1.00 42.54 ? 325 CYS A N 1 ATOM 1948 C CA . CYS A 1 259 ? 57.133 70.943 54.800 1.00 43.79 ? 325 CYS A CA 1 ATOM 1949 C C . CYS A 1 259 ? 57.410 72.373 55.288 1.00 52.61 ? 325 CYS A C 1 ATOM 1950 O O . CYS A 1 259 ? 56.450 73.124 55.480 1.00 53.42 ? 325 CYS A O 1 ATOM 1951 C CB . CYS A 1 259 ? 57.057 69.966 55.964 1.00 43.71 ? 325 CYS A CB 1 ATOM 1952 S SG . CYS A 1 259 ? 56.174 68.423 55.582 1.00 47.39 ? 325 CYS A SG 1 ATOM 1953 N N . ASN A 1 260 ? 58.696 72.761 55.438 1.00 50.17 ? 326 ASN A N 1 ATOM 1954 C CA . ASN A 1 260 ? 59.097 74.098 55.890 1.00 49.69 ? 326 ASN A CA 1 ATOM 1955 C C . ASN A 1 260 ? 58.702 75.173 54.880 1.00 53.02 ? 326 ASN A C 1 ATOM 1956 O O . ASN A 1 260 ? 58.446 76.308 55.272 1.00 54.20 ? 326 ASN A O 1 ATOM 1957 C CB . ASN A 1 260 ? 60.601 74.138 56.173 1.00 51.65 ? 326 ASN A CB 1 ATOM 1958 C CG . ASN A 1 260 ? 61.463 73.914 54.959 1.00 72.89 ? 326 ASN A CG 1 ATOM 1959 O OD1 . ASN A 1 260 ? 61.309 72.946 54.221 1.00 67.88 ? 326 ASN A OD1 1 ATOM 1960 N ND2 . ASN A 1 260 ? 62.369 74.822 54.706 1.00 61.96 ? 326 ASN A ND2 1 ATOM 1961 N N . GLU A 1 261 ? 58.624 74.811 53.593 1.00 47.84 ? 327 GLU A N 1 ATOM 1962 C CA . GLU A 1 261 ? 58.246 75.740 52.534 1.00 47.48 ? 327 GLU A CA 1 ATOM 1963 C C . GLU A 1 261 ? 56.735 76.002 52.484 1.00 51.23 ? 327 GLU A C 1 ATOM 1964 O O . GLU A 1 261 ? 56.307 77.014 51.931 1.00 50.88 ? 327 GLU A O 1 ATOM 1965 C CB . GLU A 1 261 ? 58.785 75.261 51.178 1.00 48.90 ? 327 GLU A CB 1 ATOM 1966 C CG . GLU A 1 261 ? 60.257 75.589 50.990 1.00 63.32 ? 327 GLU A CG 1 ATOM 1967 C CD . GLU A 1 261 ? 60.973 74.891 49.850 1.00 98.59 ? 327 GLU A CD 1 ATOM 1968 O OE1 . GLU A 1 261 ? 62.219 74.792 49.916 1.00 106.33 ? 327 GLU A OE1 1 ATOM 1969 O OE2 . GLU A 1 261 ? 60.299 74.431 48.900 1.00 97.94 ? 327 GLU A OE2 1 ATOM 1970 N N . GLY A 1 262 ? 55.958 75.062 53.037 1.00 47.90 ? 328 GLY A N 1 ATOM 1971 C CA . GLY A 1 262 ? 54.498 75.086 53.123 1.00 47.53 ? 328 GLY A CA 1 ATOM 1972 C C . GLY A 1 262 ? 53.863 76.422 53.486 1.00 50.47 ? 328 GLY A C 1 ATOM 1973 O O . GLY A 1 262 ? 53.072 76.946 52.696 1.00 48.54 ? 328 GLY A O 1 ATOM 1974 N N . PRO A 1 263 ? 54.215 77.053 54.636 1.00 48.00 ? 329 PRO A N 1 ATOM 1975 C CA . PRO A 1 263 ? 53.585 78.345 54.982 1.00 48.50 ? 329 PRO A CA 1 ATOM 1976 C C . PRO A 1 263 ? 53.984 79.557 54.128 1.00 54.38 ? 329 PRO A C 1 ATOM 1977 O O . PRO A 1 263 ? 53.340 80.603 54.232 1.00 55.24 ? 329 PRO A O 1 ATOM 1978 C CB . PRO A 1 263 ? 53.972 78.548 56.445 1.00 49.92 ? 329 PRO A CB 1 ATOM 1979 C CG . PRO A 1 263 ? 54.484 77.208 56.926 1.00 53.73 ? 329 PRO A CG 1 ATOM 1980 C CD . PRO A 1 263 ? 55.102 76.596 55.725 1.00 48.90 ? 329 PRO A CD 1 ATOM 1981 N N . THR A 1 264 ? 54.975 79.407 53.249 1.00 50.69 ? 330 THR A N 1 ATOM 1982 C CA . THR A 1 264 ? 55.465 80.479 52.374 1.00 50.02 ? 330 THR A CA 1 ATOM 1983 C C . THR A 1 264 ? 54.712 80.546 51.032 1.00 51.74 ? 330 THR A C 1 ATOM 1984 O O . THR A 1 264 ? 54.833 81.548 50.325 1.00 52.33 ? 330 THR A O 1 ATOM 1985 C CB . THR A 1 264 ? 57.005 80.349 52.160 1.00 59.77 ? 330 THR A CB 1 ATOM 1986 O OG1 . THR A 1 264 ? 57.287 79.470 51.051 1.00 61.26 ? 330 THR A OG1 1 ATOM 1987 C CG2 . THR A 1 264 ? 57.764 79.905 53.437 1.00 54.52 ? 330 THR A CG2 1 ATOM 1988 N N . LEU A 1 265 ? 53.981 79.470 50.673 1.00 46.03 ? 331 LEU A N 1 ATOM 1989 C CA . LEU A 1 265 ? 53.248 79.299 49.414 1.00 45.26 ? 331 LEU A CA 1 ATOM 1990 C C . LEU A 1 265 ? 52.197 80.389 49.157 1.00 49.82 ? 331 LEU A C 1 ATOM 1991 O O . LEU A 1 265 ? 51.555 80.829 50.113 1.00 48.53 ? 331 LEU A O 1 ATOM 1992 C CB . LEU A 1 265 ? 52.627 77.883 49.328 1.00 45.05 ? 331 LEU A CB 1 ATOM 1993 C CG . LEU A 1 265 ? 53.587 76.665 49.369 1.00 48.74 ? 331 LEU A CG 1 ATOM 1994 C CD1 . LEU A 1 265 ? 52.833 75.377 49.060 1.00 47.88 ? 331 LEU A CD1 1 ATOM 1995 C CD2 . LEU A 1 265 ? 54.760 76.822 48.390 1.00 49.56 ? 331 LEU A CD2 1 ATOM 1996 N N . PRO A 1 266 ? 52.012 80.857 47.891 1.00 48.25 ? 332 PRO A N 1 ATOM 1997 C CA . PRO A 1 266 ? 51.045 81.950 47.647 1.00 47.76 ? 332 PRO A CA 1 ATOM 1998 C C . PRO A 1 266 ? 49.591 81.539 47.787 1.00 50.41 ? 332 PRO A C 1 ATOM 1999 O O . PRO A 1 266 ? 49.287 80.358 47.899 1.00 49.45 ? 332 PRO A O 1 ATOM 2000 C CB . PRO A 1 266 ? 51.359 82.390 46.206 1.00 49.53 ? 332 PRO A CB 1 ATOM 2001 C CG . PRO A 1 266 ? 51.864 81.148 45.543 1.00 54.44 ? 332 PRO A CG 1 ATOM 2002 C CD . PRO A 1 266 ? 52.684 80.447 46.632 1.00 50.19 ? 332 PRO A CD 1 ATOM 2003 N N . ASP A 1 267 ? 48.692 82.528 47.762 1.00 46.69 ? 333 ASP A N 1 ATOM 2004 C CA . ASP A 1 267 ? 47.245 82.324 47.807 1.00 44.88 ? 333 ASP A CA 1 ATOM 2005 C C . ASP A 1 267 ? 46.810 81.857 46.438 1.00 46.95 ? 333 ASP A C 1 ATOM 2006 O O . ASP A 1 267 ? 47.453 82.200 45.446 1.00 46.75 ? 333 ASP A O 1 ATOM 2007 C CB . ASP A 1 267 ? 46.515 83.652 48.107 1.00 45.31 ? 333 ASP A CB 1 ATOM 2008 C CG . ASP A 1 267 ? 46.720 84.236 49.487 1.00 45.27 ? 333 ASP A CG 1 ATOM 2009 O OD1 . ASP A 1 267 ? 47.349 83.566 50.331 1.00 45.09 ? 333 ASP A OD1 1 ATOM 2010 O OD2 . ASP A 1 267 ? 46.215 85.345 49.737 1.00 51.44 ? 333 ASP A OD2 1 ATOM 2011 N N . ILE A 1 268 ? 45.736 81.066 46.384 1.00 41.94 ? 334 ILE A N 1 ATOM 2012 C CA . ILE A 1 268 ? 45.124 80.622 45.139 1.00 40.39 ? 334 ILE A CA 1 ATOM 2013 C C . ILE A 1 268 ? 43.688 81.139 45.203 1.00 42.88 ? 334 ILE A C 1 ATOM 2014 O O . ILE A 1 268 ? 43.007 80.918 46.203 1.00 42.40 ? 334 ILE A O 1 ATOM 2015 C CB . ILE A 1 268 ? 45.227 79.087 44.871 1.00 43.24 ? 334 ILE A CB 1 ATOM 2016 C CG1 . ILE A 1 268 ? 46.712 78.601 44.951 1.00 43.70 ? 334 ILE A CG1 1 ATOM 2017 C CG2 . ILE A 1 268 ? 44.584 78.735 43.507 1.00 43.37 ? 334 ILE A CG2 1 ATOM 2018 C CD1 . ILE A 1 268 ? 46.950 77.116 44.939 1.00 46.78 ? 334 ILE A CD1 1 ATOM 2019 N N . SER A 1 269 ? 43.252 81.853 44.153 1.00 38.85 ? 335 SER A N 1 ATOM 2020 C CA . SER A 1 269 ? 41.927 82.457 44.038 1.00 38.73 ? 335 SER A CA 1 ATOM 2021 C C . SER A 1 269 ? 41.187 81.919 42.835 1.00 44.30 ? 335 SER A C 1 ATOM 2022 O O . SER A 1 269 ? 41.771 81.797 41.762 1.00 45.26 ? 335 SER A O 1 ATOM 2023 C CB . SER A 1 269 ? 42.036 83.980 43.930 1.00 42.71 ? 335 SER A CB 1 ATOM 2024 O OG . SER A 1 269 ? 42.732 84.538 45.033 1.00 54.89 ? 335 SER A OG 1 ATOM 2025 N N . PHE A 1 270 ? 39.896 81.615 43.016 1.00 40.76 ? 336 PHE A N 1 ATOM 2026 C CA . PHE A 1 270 ? 39.007 81.102 41.978 1.00 40.70 ? 336 PHE A CA 1 ATOM 2027 C C . PHE A 1 270 ? 37.920 82.141 41.758 1.00 46.97 ? 336 PHE A C 1 ATOM 2028 O O . PHE A 1 270 ? 37.186 82.475 42.688 1.00 46.44 ? 336 PHE A O 1 ATOM 2029 C CB . PHE A 1 270 ? 38.408 79.718 42.381 1.00 41.66 ? 336 PHE A CB 1 ATOM 2030 C CG . PHE A 1 270 ? 39.431 78.682 42.801 1.00 41.75 ? 336 PHE A CG 1 ATOM 2031 C CD1 . PHE A 1 270 ? 40.063 77.880 41.853 1.00 43.60 ? 336 PHE A CD1 1 ATOM 2032 C CD2 . PHE A 1 270 ? 39.801 78.547 44.134 1.00 42.91 ? 336 PHE A CD2 1 ATOM 2033 C CE1 . PHE A 1 270 ? 41.060 76.973 42.228 1.00 44.26 ? 336 PHE A CE1 1 ATOM 2034 C CE2 . PHE A 1 270 ? 40.780 77.622 44.513 1.00 45.81 ? 336 PHE A CE2 1 ATOM 2035 C CZ . PHE A 1 270 ? 41.391 76.825 43.555 1.00 43.71 ? 336 PHE A CZ 1 ATOM 2036 N N . HIS A 1 271 ? 37.859 82.698 40.551 1.00 47.43 ? 337 HIS A N 1 ATOM 2037 C CA . HIS A 1 271 ? 36.883 83.722 40.188 1.00 49.54 ? 337 HIS A CA 1 ATOM 2038 C C . HIS A 1 271 ? 35.576 83.050 39.753 1.00 50.67 ? 337 HIS A C 1 ATOM 2039 O O . HIS A 1 271 ? 35.514 82.412 38.699 1.00 49.39 ? 337 HIS A O 1 ATOM 2040 C CB . HIS A 1 271 ? 37.447 84.674 39.102 1.00 52.34 ? 337 HIS A CB 1 ATOM 2041 C CG . HIS A 1 271 ? 36.710 85.981 38.978 1.00 57.72 ? 337 HIS A CG 1 ATOM 2042 N ND1 . HIS A 1 271 ? 37.320 87.098 38.430 1.00 60.49 ? 337 HIS A ND1 1 ATOM 2043 C CD2 . HIS A 1 271 ? 35.437 86.310 39.327 1.00 60.34 ? 337 HIS A CD2 1 ATOM 2044 C CE1 . HIS A 1 271 ? 36.405 88.059 38.455 1.00 60.31 ? 337 HIS A CE1 1 ATOM 2045 N NE2 . HIS A 1 271 ? 35.258 87.633 38.993 1.00 60.55 ? 337 HIS A NE2 1 ATOM 2046 N N . LEU A 1 272 ? 34.549 83.166 40.603 1.00 46.51 ? 338 LEU A N 1 ATOM 2047 C CA . LEU A 1 272 ? 33.229 82.561 40.404 1.00 46.25 ? 338 LEU A CA 1 ATOM 2048 C C . LEU A 1 272 ? 32.146 83.618 40.604 1.00 50.80 ? 338 LEU A C 1 ATOM 2049 O O . LEU A 1 272 ? 32.062 84.226 41.683 1.00 49.76 ? 338 LEU A O 1 ATOM 2050 C CB . LEU A 1 272 ? 33.006 81.383 41.407 1.00 46.19 ? 338 LEU A CB 1 ATOM 2051 C CG . LEU A 1 272 ? 34.088 80.297 41.490 1.00 50.12 ? 338 LEU A CG 1 ATOM 2052 C CD1 . LEU A 1 272 ? 33.891 79.427 42.729 1.00 50.01 ? 338 LEU A CD1 1 ATOM 2053 C CD2 . LEU A 1 272 ? 34.137 79.462 40.216 1.00 50.78 ? 338 LEU A CD2 1 ATOM 2054 N N . GLY A 1 273 ? 31.313 83.799 39.578 1.00 48.95 ? 339 GLY A N 1 ATOM 2055 C CA . GLY A 1 273 ? 30.259 84.808 39.557 1.00 49.53 ? 339 GLY A CA 1 ATOM 2056 C C . GLY A 1 273 ? 30.910 86.169 39.705 1.00 55.32 ? 339 GLY A C 1 ATOM 2057 O O . GLY A 1 273 ? 31.956 86.431 39.099 1.00 54.78 ? 339 GLY A O 1 ATOM 2058 N N . GLY A 1 274 ? 30.392 86.985 40.595 1.00 53.62 ? 340 GLY A N 1 ATOM 2059 C CA . GLY A 1 274 ? 31.012 88.280 40.830 1.00 54.46 ? 340 GLY A CA 1 ATOM 2060 C C . GLY A 1 274 ? 32.240 88.253 41.724 1.00 59.26 ? 340 GLY A C 1 ATOM 2061 O O . GLY A 1 274 ? 33.115 89.111 41.567 1.00 61.26 ? 340 GLY A O 1 ATOM 2062 N N . LYS A 1 275 ? 32.336 87.255 42.652 1.00 52.40 ? 341 LYS A N 1 ATOM 2063 C CA . LYS A 1 275 ? 33.367 87.178 43.698 1.00 50.39 ? 341 LYS A CA 1 ATOM 2064 C C . LYS A 1 275 ? 34.625 86.343 43.409 1.00 51.86 ? 341 LYS A C 1 ATOM 2065 O O . LYS A 1 275 ? 34.643 85.475 42.542 1.00 52.29 ? 341 LYS A O 1 ATOM 2066 C CB . LYS A 1 275 ? 32.730 86.678 45.018 1.00 51.68 ? 341 LYS A CB 1 ATOM 2067 N N . GLU A 1 276 ? 35.683 86.639 44.169 1.00 46.72 ? 342 GLU A N 1 ATOM 2068 C CA . GLU A 1 276 ? 36.953 85.922 44.196 1.00 46.14 ? 342 GLU A CA 1 ATOM 2069 C C . GLU A 1 276 ? 36.965 85.042 45.459 1.00 45.49 ? 342 GLU A C 1 ATOM 2070 O O . GLU A 1 276 ? 36.715 85.536 46.560 1.00 43.83 ? 342 GLU A O 1 ATOM 2071 C CB . GLU A 1 276 ? 38.152 86.901 44.170 1.00 47.94 ? 342 GLU A CB 1 ATOM 2072 C CG . GLU A 1 276 ? 38.483 87.445 42.781 1.00 59.34 ? 342 GLU A CG 1 ATOM 2073 C CD . GLU A 1 276 ? 39.234 86.520 41.833 1.00 83.10 ? 342 GLU A CD 1 ATOM 2074 O OE1 . GLU A 1 276 ? 39.326 86.843 40.626 1.00 74.49 ? 342 GLU A OE1 1 ATOM 2075 O OE2 . GLU A 1 276 ? 39.728 85.470 42.299 1.00 77.33 ? 342 GLU A OE2 1 ATOM 2076 N N . TYR A 1 277 ? 37.190 83.735 45.276 1.00 40.37 ? 343 TYR A N 1 ATOM 2077 C CA . TYR A 1 277 ? 37.219 82.718 46.336 1.00 38.69 ? 343 TYR A CA 1 ATOM 2078 C C . TYR A 1 277 ? 38.670 82.296 46.581 1.00 44.20 ? 343 TYR A C 1 ATOM 2079 O O . TYR A 1 277 ? 39.257 81.559 45.791 1.00 45.29 ? 343 TYR A O 1 ATOM 2080 C CB . TYR A 1 277 ? 36.266 81.558 45.993 1.00 38.16 ? 343 TYR A CB 1 ATOM 2081 C CG . TYR A 1 277 ? 34.808 81.989 45.991 1.00 38.74 ? 343 TYR A CG 1 ATOM 2082 C CD1 . TYR A 1 277 ? 34.060 81.997 47.166 1.00 39.26 ? 343 TYR A CD1 1 ATOM 2083 C CD2 . TYR A 1 277 ? 34.217 82.522 44.842 1.00 39.76 ? 343 TYR A CD2 1 ATOM 2084 C CE1 . TYR A 1 277 ? 32.750 82.474 47.189 1.00 37.65 ? 343 TYR A CE1 1 ATOM 2085 C CE2 . TYR A 1 277 ? 32.904 82.991 44.852 1.00 40.18 ? 343 TYR A CE2 1 ATOM 2086 C CZ . TYR A 1 277 ? 32.174 82.963 46.029 1.00 43.16 ? 343 TYR A CZ 1 ATOM 2087 O OH . TYR A 1 277 ? 30.880 83.426 46.056 1.00 45.03 ? 343 TYR A OH 1 ATOM 2088 N N . THR A 1 278 ? 39.264 82.842 47.645 1.00 40.04 ? 344 THR A N 1 ATOM 2089 C CA . THR A 1 278 ? 40.674 82.692 47.968 1.00 39.29 ? 344 THR A CA 1 ATOM 2090 C C . THR A 1 278 ? 40.953 81.707 49.082 1.00 44.27 ? 344 THR A C 1 ATOM 2091 O O . THR A 1 278 ? 40.350 81.750 50.153 1.00 45.06 ? 344 THR A O 1 ATOM 2092 C CB . THR A 1 278 ? 41.289 84.097 48.254 1.00 42.77 ? 344 THR A CB 1 ATOM 2093 O OG1 . THR A 1 278 ? 41.067 84.902 47.104 1.00 38.36 ? 344 THR A OG1 1 ATOM 2094 C CG2 . THR A 1 278 ? 42.803 84.069 48.553 1.00 38.59 ? 344 THR A CG2 1 ATOM 2095 N N . LEU A 1 279 ? 41.937 80.856 48.817 1.00 41.96 ? 345 LEU A N 1 ATOM 2096 C CA . LEU A 1 279 ? 42.496 79.866 49.717 1.00 42.51 ? 345 LEU A CA 1 ATOM 2097 C C . LEU A 1 279 ? 43.960 80.247 49.954 1.00 47.06 ? 345 LEU A C 1 ATOM 2098 O O . LEU A 1 279 ? 44.688 80.525 49.005 1.00 47.88 ? 345 LEU A O 1 ATOM 2099 C CB . LEU A 1 279 ? 42.476 78.462 49.064 1.00 42.40 ? 345 LEU A CB 1 ATOM 2100 C CG . LEU A 1 279 ? 41.186 77.673 48.906 1.00 46.36 ? 345 LEU A CG 1 ATOM 2101 C CD1 . LEU A 1 279 ? 41.516 76.303 48.478 1.00 45.53 ? 345 LEU A CD1 1 ATOM 2102 C CD2 . LEU A 1 279 ? 40.313 77.663 50.100 1.00 49.78 ? 345 LEU A CD2 1 ATOM 2103 N N . THR A 1 280 ? 44.382 80.261 51.213 1.00 43.53 ? 346 THR A N 1 ATOM 2104 C CA . THR A 1 280 ? 45.778 80.513 51.590 1.00 42.54 ? 346 THR A CA 1 ATOM 2105 C C . THR A 1 280 ? 46.456 79.141 51.653 1.00 44.11 ? 346 THR A C 1 ATOM 2106 O O . THR A 1 280 ? 45.765 78.124 51.526 1.00 41.72 ? 346 THR A O 1 ATOM 2107 C CB . THR A 1 280 ? 45.859 81.259 52.942 1.00 46.09 ? 346 THR A CB 1 ATOM 2108 O OG1 . THR A 1 280 ? 45.382 80.410 53.983 1.00 43.22 ? 346 THR A OG1 1 ATOM 2109 C CG2 . THR A 1 280 ? 45.089 82.567 52.931 1.00 45.73 ? 346 THR A CG2 1 ATOM 2110 N N . SER A 1 281 ? 47.788 79.108 51.866 1.00 41.19 ? 347 SER A N 1 ATOM 2111 C CA . SER A 1 281 ? 48.544 77.856 51.975 1.00 40.83 ? 347 SER A CA 1 ATOM 2112 C C . SER A 1 281 ? 48.017 76.936 53.095 1.00 44.22 ? 347 SER A C 1 ATOM 2113 O O . SER A 1 281 ? 47.981 75.715 52.927 1.00 42.79 ? 347 SER A O 1 ATOM 2114 C CB . SER A 1 281 ? 50.035 78.119 52.136 1.00 43.55 ? 347 SER A CB 1 ATOM 2115 O OG . SER A 1 281 ? 50.306 78.955 53.249 1.00 56.93 ? 347 SER A OG 1 ATOM 2116 N N . ALA A 1 282 ? 47.535 77.520 54.195 1.00 40.58 ? 348 ALA A N 1 ATOM 2117 C CA . ALA A 1 282 ? 46.972 76.756 55.310 1.00 39.84 ? 348 ALA A CA 1 ATOM 2118 C C . ALA A 1 282 ? 45.708 75.976 54.881 1.00 42.57 ? 348 ALA A C 1 ATOM 2119 O O . ALA A 1 282 ? 45.442 74.901 55.426 1.00 44.23 ? 348 ALA A O 1 ATOM 2120 C CB . ALA A 1 282 ? 46.658 77.680 56.470 1.00 40.43 ? 348 ALA A CB 1 ATOM 2121 N N . ASP A 1 283 ? 44.989 76.478 53.861 1.00 35.98 ? 349 ASP A N 1 ATOM 2122 C CA . ASP A 1 283 ? 43.780 75.868 53.305 1.00 35.32 ? 349 ASP A CA 1 ATOM 2123 C C . ASP A 1 283 ? 44.035 74.745 52.311 1.00 40.64 ? 349 ASP A C 1 ATOM 2124 O O . ASP A 1 283 ? 43.117 73.960 52.082 1.00 40.92 ? 349 ASP A O 1 ATOM 2125 C CB . ASP A 1 283 ? 42.877 76.926 52.647 1.00 36.02 ? 349 ASP A CB 1 ATOM 2126 C CG . ASP A 1 283 ? 42.375 77.989 53.577 1.00 40.04 ? 349 ASP A CG 1 ATOM 2127 O OD1 . ASP A 1 283 ? 41.908 77.634 54.690 1.00 42.83 ? 349 ASP A OD1 1 ATOM 2128 O OD2 . ASP A 1 283 ? 42.404 79.167 53.187 1.00 42.56 ? 349 ASP A OD2 1 ATOM 2129 N N . TYR A 1 284 ? 45.229 74.687 51.673 1.00 37.78 ? 350 TYR A N 1 ATOM 2130 C CA . TYR A 1 284 ? 45.489 73.643 50.676 1.00 38.00 ? 350 TYR A CA 1 ATOM 2131 C C . TYR A 1 284 ? 46.746 72.799 50.971 1.00 42.82 ? 350 TYR A C 1 ATOM 2132 O O . TYR A 1 284 ? 46.999 71.859 50.239 1.00 42.71 ? 350 TYR A O 1 ATOM 2133 C CB . TYR A 1 284 ? 45.491 74.210 49.240 1.00 39.79 ? 350 TYR A CB 1 ATOM 2134 C CG . TYR A 1 284 ? 46.624 75.159 48.910 1.00 42.55 ? 350 TYR A CG 1 ATOM 2135 C CD1 . TYR A 1 284 ? 47.854 74.680 48.473 1.00 44.93 ? 350 TYR A CD1 1 ATOM 2136 C CD2 . TYR A 1 284 ? 46.435 76.538 48.933 1.00 43.53 ? 350 TYR A CD2 1 ATOM 2137 C CE1 . TYR A 1 284 ? 48.895 75.544 48.144 1.00 46.72 ? 350 TYR A CE1 1 ATOM 2138 C CE2 . TYR A 1 284 ? 47.469 77.415 48.604 1.00 44.74 ? 350 TYR A CE2 1 ATOM 2139 C CZ . TYR A 1 284 ? 48.695 76.911 48.199 1.00 53.15 ? 350 TYR A CZ 1 ATOM 2140 O OH . TYR A 1 284 ? 49.736 77.741 47.877 1.00 51.22 ? 350 TYR A OH 1 ATOM 2141 N N . VAL A 1 285 ? 47.507 73.101 52.035 1.00 40.25 ? 351 VAL A N 1 ATOM 2142 C CA . VAL A 1 285 ? 48.698 72.314 52.388 1.00 39.07 ? 351 VAL A CA 1 ATOM 2143 C C . VAL A 1 285 ? 48.357 71.446 53.576 1.00 42.85 ? 351 VAL A C 1 ATOM 2144 O O . VAL A 1 285 ? 47.882 71.956 54.593 1.00 39.89 ? 351 VAL A O 1 ATOM 2145 C CB . VAL A 1 285 ? 50.004 73.137 52.680 1.00 41.28 ? 351 VAL A CB 1 ATOM 2146 C CG1 . VAL A 1 285 ? 51.181 72.212 53.034 1.00 40.80 ? 351 VAL A CG1 1 ATOM 2147 C CG2 . VAL A 1 285 ? 50.379 74.031 51.511 1.00 40.91 ? 351 VAL A CG2 1 ATOM 2148 N N . PHE A 1 286 ? 48.648 70.137 53.473 1.00 41.31 ? 352 PHE A N 1 ATOM 2149 C CA . PHE A 1 286 ? 48.463 69.233 54.606 1.00 41.90 ? 352 PHE A CA 1 ATOM 2150 C C . PHE A 1 286 ? 49.743 69.367 55.413 1.00 45.25 ? 352 PHE A C 1 ATOM 2151 O O . PHE A 1 286 ? 50.735 68.671 55.183 1.00 43.55 ? 352 PHE A O 1 ATOM 2152 C CB . PHE A 1 286 ? 48.177 67.790 54.148 1.00 44.76 ? 352 PHE A CB 1 ATOM 2153 C CG . PHE A 1 286 ? 46.797 67.573 53.546 1.00 48.02 ? 352 PHE A CG 1 ATOM 2154 C CD1 . PHE A 1 286 ? 45.649 67.761 54.307 1.00 53.01 ? 352 PHE A CD1 1 ATOM 2155 C CD2 . PHE A 1 286 ? 46.651 67.116 52.241 1.00 51.63 ? 352 PHE A CD2 1 ATOM 2156 C CE1 . PHE A 1 286 ? 44.379 67.538 53.760 1.00 54.74 ? 352 PHE A CE1 1 ATOM 2157 C CE2 . PHE A 1 286 ? 45.382 66.873 51.703 1.00 55.84 ? 352 PHE A CE2 1 ATOM 2158 C CZ . PHE A 1 286 ? 44.256 67.082 52.469 1.00 54.04 ? 352 PHE A CZ 1 ATOM 2159 N N . GLN A 1 287 ? 49.735 70.377 56.285 1.00 44.08 ? 353 GLN A N 1 ATOM 2160 C CA . GLN A 1 287 ? 50.837 70.782 57.143 1.00 46.01 ? 353 GLN A CA 1 ATOM 2161 C C . GLN A 1 287 ? 51.053 69.780 58.303 1.00 57.61 ? 353 GLN A C 1 ATOM 2162 O O . GLN A 1 287 ? 50.807 70.113 59.465 1.00 59.10 ? 353 GLN A O 1 ATOM 2163 C CB . GLN A 1 287 ? 50.578 72.223 57.635 1.00 46.46 ? 353 GLN A CB 1 ATOM 2164 C CG . GLN A 1 287 ? 51.824 73.015 58.023 1.00 44.74 ? 353 GLN A CG 1 ATOM 2165 C CD . GLN A 1 287 ? 52.800 73.224 56.885 1.00 51.20 ? 353 GLN A CD 1 ATOM 2166 O OE1 . GLN A 1 287 ? 52.484 73.819 55.856 1.00 40.15 ? 353 GLN A OE1 1 ATOM 2167 N NE2 . GLN A 1 287 ? 54.027 72.776 57.073 1.00 37.59 ? 353 GLN A NE2 1 ATOM 2168 N N . GLU A 1 288 ? 51.513 68.550 57.982 1.00 57.78 ? 354 GLU A N 1 ATOM 2169 C CA . GLU A 1 288 ? 51.696 67.494 58.988 1.00 59.33 ? 354 GLU A CA 1 ATOM 2170 C C . GLU A 1 288 ? 52.910 67.738 59.909 1.00 65.55 ? 354 GLU A C 1 ATOM 2171 O O . GLU A 1 288 ? 52.972 67.155 61.001 1.00 67.42 ? 354 GLU A O 1 ATOM 2172 C CB . GLU A 1 288 ? 51.711 66.082 58.361 1.00 60.96 ? 354 GLU A CB 1 ATOM 2173 C CG . GLU A 1 288 ? 52.885 65.781 57.438 1.00 75.51 ? 354 GLU A CG 1 ATOM 2174 C CD . GLU A 1 288 ? 52.743 64.558 56.549 1.00 98.32 ? 354 GLU A CD 1 ATOM 2175 O OE1 . GLU A 1 288 ? 52.072 63.581 56.956 1.00 98.46 ? 354 GLU A OE1 1 ATOM 2176 O OE2 . GLU A 1 288 ? 53.324 64.575 55.441 1.00 89.55 ? 354 GLU A OE2 1 ATOM 2177 N N . SER A 1 289 ? 53.831 68.630 59.485 1.00 59.91 ? 355 SER A N 1 ATOM 2178 C CA . SER A 1 289 ? 55.052 69.081 60.186 1.00 58.63 ? 355 SER A CA 1 ATOM 2179 C C . SER A 1 289 ? 55.582 70.336 59.477 1.00 61.87 ? 355 SER A C 1 ATOM 2180 O O . SER A 1 289 ? 55.019 70.719 58.459 1.00 61.73 ? 355 SER A O 1 ATOM 2181 C CB . SER A 1 289 ? 56.120 67.982 60.201 1.00 62.09 ? 355 SER A CB 1 ATOM 2182 O OG . SER A 1 289 ? 57.128 68.103 59.204 1.00 67.89 ? 355 SER A OG 1 ATOM 2183 N N . TYR A 1 290 ? 56.641 70.980 60.002 1.00 58.76 ? 356 TYR A N 1 ATOM 2184 C CA . TYR A 1 290 ? 57.273 72.152 59.366 1.00 59.02 ? 356 TYR A CA 1 ATOM 2185 C C . TYR A 1 290 ? 58.737 71.835 59.074 1.00 63.07 ? 356 TYR A C 1 ATOM 2186 O O . TYR A 1 290 ? 59.528 72.732 58.791 1.00 62.02 ? 356 TYR A O 1 ATOM 2187 C CB . TYR A 1 290 ? 57.229 73.408 60.258 1.00 60.13 ? 356 TYR A CB 1 ATOM 2188 C CG . TYR A 1 290 ? 55.869 73.888 60.701 1.00 62.08 ? 356 TYR A CG 1 ATOM 2189 C CD1 . TYR A 1 290 ? 55.078 74.668 59.864 1.00 64.03 ? 356 TYR A CD1 1 ATOM 2190 C CD2 . TYR A 1 290 ? 55.430 73.679 62.005 1.00 63.63 ? 356 TYR A CD2 1 ATOM 2191 C CE1 . TYR A 1 290 ? 53.840 75.150 60.283 1.00 65.01 ? 356 TYR A CE1 1 ATOM 2192 C CE2 . TYR A 1 290 ? 54.207 74.178 62.446 1.00 64.96 ? 356 TYR A CE2 1 ATOM 2193 C CZ . TYR A 1 290 ? 53.411 74.905 61.578 1.00 74.55 ? 356 TYR A CZ 1 ATOM 2194 O OH . TYR A 1 290 ? 52.202 75.376 62.023 1.00 80.52 ? 356 TYR A OH 1 ATOM 2195 N N . SER A 1 291 ? 59.101 70.565 59.171 1.00 61.38 ? 357 SER A N 1 ATOM 2196 C CA . SER A 1 291 ? 60.467 70.118 58.981 1.00 62.08 ? 357 SER A CA 1 ATOM 2197 C C . SER A 1 291 ? 60.961 70.220 57.550 1.00 66.05 ? 357 SER A C 1 ATOM 2198 O O . SER A 1 291 ? 60.279 69.778 56.634 1.00 65.25 ? 357 SER A O 1 ATOM 2199 C CB . SER A 1 291 ? 60.630 68.693 59.497 1.00 66.85 ? 357 SER A CB 1 ATOM 2200 O OG . SER A 1 291 ? 61.923 68.197 59.189 1.00 76.84 ? 357 SER A OG 1 ATOM 2201 N N . SER A 1 292 ? 62.192 70.743 57.380 1.00 63.60 ? 358 SER A N 1 ATOM 2202 C CA . SER A 1 292 ? 62.918 70.837 56.111 1.00 63.43 ? 358 SER A CA 1 ATOM 2203 C C . SER A 1 292 ? 63.337 69.421 55.625 1.00 66.93 ? 358 SER A C 1 ATOM 2204 O O . SER A 1 292 ? 63.782 69.257 54.496 1.00 65.33 ? 358 SER A O 1 ATOM 2205 C CB . SER A 1 292 ? 64.145 71.736 56.274 1.00 67.76 ? 358 SER A CB 1 ATOM 2206 O OG . SER A 1 292 ? 64.966 71.328 57.356 1.00 78.48 ? 358 SER A OG 1 ATOM 2207 N N . LYS A 1 293 ? 63.185 68.403 56.511 1.00 64.64 ? 359 LYS A N 1 ATOM 2208 C CA . LYS A 1 293 ? 63.520 66.986 56.307 1.00 64.26 ? 359 LYS A CA 1 ATOM 2209 C C . LYS A 1 293 ? 62.289 66.101 55.950 1.00 66.39 ? 359 LYS A C 1 ATOM 2210 O O . LYS A 1 293 ? 62.440 64.883 55.789 1.00 66.37 ? 359 LYS A O 1 ATOM 2211 C CB . LYS A 1 293 ? 64.244 66.438 57.551 1.00 66.89 ? 359 LYS A CB 1 ATOM 2212 N N . LYS A 1 294 ? 61.079 66.700 55.835 1.00 59.30 ? 360 LYS A N 1 ATOM 2213 C CA . LYS A 1 294 ? 59.871 65.952 55.469 1.00 56.94 ? 360 LYS A CA 1 ATOM 2214 C C . LYS A 1 294 ? 59.132 66.614 54.302 1.00 56.51 ? 360 LYS A C 1 ATOM 2215 O O . LYS A 1 294 ? 59.344 67.797 54.026 1.00 57.09 ? 360 LYS A O 1 ATOM 2216 C CB . LYS A 1 294 ? 58.961 65.718 56.687 1.00 59.04 ? 360 LYS A CB 1 ATOM 2217 N N . LEU A 1 295 ? 58.312 65.833 53.578 1.00 48.62 ? 361 LEU A N 1 ATOM 2218 C CA . LEU A 1 295 ? 57.518 66.316 52.441 1.00 45.61 ? 361 LEU A CA 1 ATOM 2219 C C . LEU A 1 295 ? 56.059 66.431 52.870 1.00 47.14 ? 361 LEU A C 1 ATOM 2220 O O . LEU A 1 295 ? 55.558 65.583 53.618 1.00 45.73 ? 361 LEU A O 1 ATOM 2221 C CB . LEU A 1 295 ? 57.638 65.386 51.219 1.00 44.40 ? 361 LEU A CB 1 ATOM 2222 C CG . LEU A 1 295 ? 59.045 65.102 50.673 1.00 46.41 ? 361 LEU A CG 1 ATOM 2223 C CD1 . LEU A 1 295 ? 59.029 63.877 49.797 1.00 45.65 ? 361 LEU A CD1 1 ATOM 2224 C CD2 . LEU A 1 295 ? 59.596 66.285 49.900 1.00 45.16 ? 361 LEU A CD2 1 ATOM 2225 N N . CYS A 1 296 ? 55.399 67.514 52.452 1.00 42.23 ? 362 CYS A N 1 ATOM 2226 C CA . CYS A 1 296 ? 54.008 67.760 52.805 1.00 41.67 ? 362 CYS A CA 1 ATOM 2227 C C . CYS A 1 296 ? 53.145 67.745 51.558 1.00 43.43 ? 362 CYS A C 1 ATOM 2228 O O . CYS A 1 296 ? 53.490 68.399 50.576 1.00 42.62 ? 362 CYS A O 1 ATOM 2229 C CB . CYS A 1 296 ? 53.867 69.070 53.586 1.00 42.37 ? 362 CYS A CB 1 ATOM 2230 S SG . CYS A 1 296 ? 54.223 68.932 55.362 1.00 46.76 ? 362 CYS A SG 1 ATOM 2231 N N . THR A 1 297 ? 52.036 66.981 51.580 1.00 39.16 ? 363 THR A N 1 ATOM 2232 C CA . THR A 1 297 ? 51.112 66.869 50.435 1.00 38.91 ? 363 THR A CA 1 ATOM 2233 C C . THR A 1 297 ? 50.210 68.109 50.312 1.00 40.87 ? 363 THR A C 1 ATOM 2234 O O . THR A 1 297 ? 49.954 68.792 51.295 1.00 39.23 ? 363 THR A O 1 ATOM 2235 C CB . THR A 1 297 ? 50.267 65.563 50.519 1.00 49.70 ? 363 THR A CB 1 ATOM 2236 O OG1 . THR A 1 297 ? 51.109 64.429 50.749 1.00 59.07 ? 363 THR A OG1 1 ATOM 2237 C CG2 . THR A 1 297 ? 49.449 65.311 49.263 1.00 43.51 ? 363 THR A CG2 1 ATOM 2238 N N . LEU A 1 298 ? 49.715 68.357 49.103 1.00 37.79 ? 364 LEU A N 1 ATOM 2239 C CA . LEU A 1 298 ? 48.803 69.425 48.778 1.00 38.31 ? 364 LEU A CA 1 ATOM 2240 C C . LEU A 1 298 ? 47.424 68.848 48.455 1.00 43.70 ? 364 LEU A C 1 ATOM 2241 O O . LEU A 1 298 ? 47.305 67.777 47.846 1.00 43.97 ? 364 LEU A O 1 ATOM 2242 C CB . LEU A 1 298 ? 49.324 70.288 47.605 1.00 38.52 ? 364 LEU A CB 1 ATOM 2243 C CG . LEU A 1 298 ? 50.784 70.758 47.632 1.00 43.99 ? 364 LEU A CG 1 ATOM 2244 C CD1 . LEU A 1 298 ? 51.086 71.658 46.448 1.00 44.11 ? 364 LEU A CD1 1 ATOM 2245 C CD2 . LEU A 1 298 ? 51.148 71.494 48.949 1.00 44.64 ? 364 LEU A CD2 1 ATOM 2246 N N . ALA A 1 299 ? 46.383 69.588 48.837 1.00 40.13 ? 365 ALA A N 1 ATOM 2247 C CA . ALA A 1 299 ? 45.002 69.179 48.620 1.00 40.19 ? 365 ALA A CA 1 ATOM 2248 C C . ALA A 1 299 ? 44.465 69.654 47.249 1.00 43.18 ? 365 ALA A C 1 ATOM 2249 O O . ALA A 1 299 ? 43.305 70.028 47.109 1.00 40.77 ? 365 ALA A O 1 ATOM 2250 C CB . ALA A 1 299 ? 44.136 69.659 49.770 1.00 40.98 ? 365 ALA A CB 1 ATOM 2251 N N . ILE A 1 300 ? 45.359 69.642 46.249 1.00 41.95 ? 366 ILE A N 1 ATOM 2252 C CA . ILE A 1 300 ? 45.131 69.981 44.838 1.00 41.93 ? 366 ILE A CA 1 ATOM 2253 C C . ILE A 1 300 ? 45.813 68.885 44.002 1.00 46.81 ? 366 ILE A C 1 ATOM 2254 O O . ILE A 1 300 ? 46.984 68.593 44.222 1.00 46.28 ? 366 ILE A O 1 ATOM 2255 C CB . ILE A 1 300 ? 45.607 71.399 44.449 1.00 44.62 ? 366 ILE A CB 1 ATOM 2256 C CG1 . ILE A 1 300 ? 45.006 72.474 45.378 1.00 45.37 ? 366 ILE A CG1 1 ATOM 2257 C CG2 . ILE A 1 300 ? 45.279 71.688 42.980 1.00 44.49 ? 366 ILE A CG2 1 ATOM 2258 C CD1 . ILE A 1 300 ? 45.802 73.705 45.474 1.00 50.74 ? 366 ILE A CD1 1 ATOM 2259 N N . HIS A 1 301 ? 45.060 68.242 43.100 1.00 44.62 ? 367 HIS A N 1 ATOM 2260 C CA . HIS A 1 301 ? 45.536 67.142 42.261 1.00 45.46 ? 367 HIS A CA 1 ATOM 2261 C C . HIS A 1 301 ? 45.152 67.366 40.799 1.00 48.52 ? 367 HIS A C 1 ATOM 2262 O O . HIS A 1 301 ? 44.258 68.165 40.493 1.00 46.20 ? 367 HIS A O 1 ATOM 2263 C CB . HIS A 1 301 ? 44.913 65.803 42.739 1.00 47.35 ? 367 HIS A CB 1 ATOM 2264 C CG . HIS A 1 301 ? 45.381 65.316 44.078 1.00 52.44 ? 367 HIS A CG 1 ATOM 2265 N ND1 . HIS A 1 301 ? 45.937 64.051 44.224 1.00 54.94 ? 367 HIS A ND1 1 ATOM 2266 C CD2 . HIS A 1 301 ? 45.351 65.928 45.296 1.00 55.31 ? 367 HIS A CD2 1 ATOM 2267 C CE1 . HIS A 1 301 ? 46.229 63.938 45.516 1.00 55.14 ? 367 HIS A CE1 1 ATOM 2268 N NE2 . HIS A 1 301 ? 45.886 65.042 46.203 1.00 55.43 ? 367 HIS A NE2 1 ATOM 2269 N N . ALA A 1 302 ? 45.801 66.624 39.896 1.00 46.74 ? 368 ALA A N 1 ATOM 2270 C CA . ALA A 1 302 ? 45.476 66.645 38.463 1.00 46.79 ? 368 ALA A CA 1 ATOM 2271 C C . ALA A 1 302 ? 44.427 65.573 38.251 1.00 49.23 ? 368 ALA A C 1 ATOM 2272 O O . ALA A 1 302 ? 44.549 64.492 38.826 1.00 46.08 ? 368 ALA A O 1 ATOM 2273 C CB . ALA A 1 302 ? 46.708 66.323 37.628 1.00 47.50 ? 368 ALA A CB 1 ATOM 2274 N N . MET A 1 303 ? 43.398 65.867 37.445 1.00 47.37 ? 369 MET A N 1 ATOM 2275 C CA . MET A 1 303 ? 42.327 64.921 37.147 1.00 48.21 ? 369 MET A CA 1 ATOM 2276 C C . MET A 1 303 ? 41.714 65.314 35.824 1.00 51.90 ? 369 MET A C 1 ATOM 2277 O O . MET A 1 303 ? 41.118 66.388 35.705 1.00 50.54 ? 369 MET A O 1 ATOM 2278 C CB . MET A 1 303 ? 41.280 64.894 38.281 1.00 51.94 ? 369 MET A CB 1 ATOM 2279 C CG . MET A 1 303 ? 40.095 64.017 38.037 1.00 58.33 ? 369 MET A CG 1 ATOM 2280 S SD . MET A 1 303 ? 40.463 62.298 38.375 1.00 66.57 ? 369 MET A SD 1 ATOM 2281 C CE . MET A 1 303 ? 40.461 62.298 40.228 1.00 63.24 ? 369 MET A CE 1 ATOM 2282 N N . ASP A 1 304 ? 41.890 64.455 34.811 1.00 49.93 ? 370 ASP A N 1 ATOM 2283 C CA . ASP A 1 304 ? 41.327 64.712 33.492 1.00 50.09 ? 370 ASP A CA 1 ATOM 2284 C C . ASP A 1 304 ? 39.956 64.083 33.410 1.00 55.06 ? 370 ASP A C 1 ATOM 2285 O O . ASP A 1 304 ? 39.831 62.860 33.329 1.00 55.10 ? 370 ASP A O 1 ATOM 2286 C CB . ASP A 1 304 ? 42.265 64.254 32.358 1.00 51.30 ? 370 ASP A CB 1 ATOM 2287 C CG . ASP A 1 304 ? 43.590 64.986 32.356 1.00 58.75 ? 370 ASP A CG 1 ATOM 2288 O OD1 . ASP A 1 304 ? 43.580 66.243 32.332 1.00 58.22 ? 370 ASP A OD1 1 ATOM 2289 O OD2 . ASP A 1 304 ? 44.633 64.311 32.398 1.00 63.87 ? 370 ASP A OD2 1 ATOM 2290 N N . ILE A 1 305 ? 38.923 64.925 33.520 1.00 52.27 ? 371 ILE A N 1 ATOM 2291 C CA . ILE A 1 305 ? 37.538 64.475 33.469 1.00 51.81 ? 371 ILE A CA 1 ATOM 2292 C C . ILE A 1 305 ? 37.103 64.421 32.007 1.00 58.97 ? 371 ILE A C 1 ATOM 2293 O O . ILE A 1 305 ? 37.312 65.400 31.287 1.00 57.91 ? 371 ILE A O 1 ATOM 2294 C CB . ILE A 1 305 ? 36.608 65.282 34.424 1.00 53.49 ? 371 ILE A CB 1 ATOM 2295 C CG1 . ILE A 1 305 ? 36.992 65.007 35.897 1.00 52.56 ? 371 ILE A CG1 1 ATOM 2296 C CG2 . ILE A 1 305 ? 35.125 64.959 34.180 1.00 52.56 ? 371 ILE A CG2 1 ATOM 2297 C CD1 . ILE A 1 305 ? 36.991 66.181 36.818 1.00 53.89 ? 371 ILE A CD1 1 ATOM 2298 N N . PRO A 1 306 ? 36.604 63.256 31.519 1.00 58.94 ? 372 PRO A N 1 ATOM 2299 C CA . PRO A 1 306 ? 36.258 63.159 30.089 1.00 59.39 ? 372 PRO A CA 1 ATOM 2300 C C . PRO A 1 306 ? 34.955 63.866 29.703 1.00 63.40 ? 372 PRO A C 1 ATOM 2301 O O . PRO A 1 306 ? 34.107 64.068 30.573 1.00 62.71 ? 372 PRO A O 1 ATOM 2302 C CB . PRO A 1 306 ? 36.207 61.646 29.840 1.00 60.96 ? 372 PRO A CB 1 ATOM 2303 C CG . PRO A 1 306 ? 35.829 61.066 31.150 1.00 65.22 ? 372 PRO A CG 1 ATOM 2304 C CD . PRO A 1 306 ? 36.346 61.982 32.227 1.00 60.74 ? 372 PRO A CD 1 ATOM 2305 N N . PRO A 1 307 ? 34.751 64.212 28.406 1.00 60.86 ? 373 PRO A N 1 ATOM 2306 C CA . PRO A 1 307 ? 33.486 64.853 28.006 1.00 60.94 ? 373 PRO A CA 1 ATOM 2307 C C . PRO A 1 307 ? 32.260 63.948 28.215 1.00 65.97 ? 373 PRO A C 1 ATOM 2308 O O . PRO A 1 307 ? 32.431 62.740 28.394 1.00 65.85 ? 373 PRO A O 1 ATOM 2309 C CB . PRO A 1 307 ? 33.712 65.219 26.528 1.00 62.33 ? 373 PRO A CB 1 ATOM 2310 C CG . PRO A 1 307 ? 35.188 65.172 26.330 1.00 66.93 ? 373 PRO A CG 1 ATOM 2311 C CD . PRO A 1 307 ? 35.655 64.076 27.245 1.00 62.76 ? 373 PRO A CD 1 ATOM 2312 N N . PRO A 1 308 ? 31.018 64.494 28.280 1.00 62.45 ? 374 PRO A N 1 ATOM 2313 C CA . PRO A 1 308 ? 30.629 65.908 28.096 1.00 61.71 ? 374 PRO A CA 1 ATOM 2314 C C . PRO A 1 308 ? 30.904 66.828 29.300 1.00 64.16 ? 374 PRO A C 1 ATOM 2315 O O . PRO A 1 308 ? 31.015 68.043 29.109 1.00 64.04 ? 374 PRO A O 1 ATOM 2316 C CB . PRO A 1 308 ? 29.144 65.807 27.736 1.00 63.07 ? 374 PRO A CB 1 ATOM 2317 C CG . PRO A 1 308 ? 28.668 64.597 28.478 1.00 67.51 ? 374 PRO A CG 1 ATOM 2318 C CD . PRO A 1 308 ? 29.836 63.636 28.497 1.00 63.44 ? 374 PRO A CD 1 ATOM 2319 N N . THR A 1 309 ? 31.043 66.258 30.518 1.00 59.22 ? 375 THR A N 1 ATOM 2320 C CA . THR A 1 309 ? 31.289 67.017 31.758 1.00 57.93 ? 375 THR A CA 1 ATOM 2321 C C . THR A 1 309 ? 32.621 67.777 31.723 1.00 58.58 ? 375 THR A C 1 ATOM 2322 O O . THR A 1 309 ? 32.652 68.973 32.026 1.00 58.13 ? 375 THR A O 1 ATOM 2323 C CB . THR A 1 309 ? 31.168 66.113 32.990 1.00 67.85 ? 375 THR A CB 1 ATOM 2324 O OG1 . THR A 1 309 ? 29.972 65.346 32.896 1.00 66.50 ? 375 THR A OG1 1 ATOM 2325 C CG2 . THR A 1 309 ? 31.161 66.896 34.293 1.00 67.56 ? 375 THR A CG2 1 ATOM 2326 N N . GLY A 1 310 ? 33.687 67.078 31.343 1.00 52.41 ? 376 GLY A N 1 ATOM 2327 C CA . GLY A 1 310 ? 35.024 67.641 31.253 1.00 51.32 ? 376 GLY A CA 1 ATOM 2328 C C . GLY A 1 310 ? 35.438 68.015 29.844 1.00 55.26 ? 376 GLY A C 1 ATOM 2329 O O . GLY A 1 310 ? 34.681 67.772 28.901 1.00 55.51 ? 376 GLY A O 1 ATOM 2330 N N . PRO A 1 311 ? 36.636 68.605 29.634 1.00 51.45 ? 377 PRO A N 1 ATOM 2331 C CA . PRO A 1 311 ? 37.654 69.004 30.629 1.00 51.39 ? 377 PRO A CA 1 ATOM 2332 C C . PRO A 1 311 ? 37.089 70.053 31.594 1.00 53.91 ? 377 PRO A C 1 ATOM 2333 O O . PRO A 1 311 ? 36.393 70.983 31.164 1.00 53.92 ? 377 PRO A O 1 ATOM 2334 C CB . PRO A 1 311 ? 38.809 69.544 29.763 1.00 52.95 ? 377 PRO A CB 1 ATOM 2335 C CG . PRO A 1 311 ? 38.555 69.008 28.389 1.00 57.40 ? 377 PRO A CG 1 ATOM 2336 C CD . PRO A 1 311 ? 37.062 68.975 28.275 1.00 52.71 ? 377 PRO A CD 1 ATOM 2337 N N . THR A 1 312 ? 37.319 69.850 32.908 1.00 47.22 ? 378 THR A N 1 ATOM 2338 C CA . THR A 1 312 ? 36.788 70.726 33.952 1.00 45.03 ? 378 THR A CA 1 ATOM 2339 C C . THR A 1 312 ? 37.611 70.734 35.212 1.00 46.19 ? 378 THR A C 1 ATOM 2340 O O . THR A 1 312 ? 38.351 69.770 35.495 1.00 45.47 ? 378 THR A O 1 ATOM 2341 C CB . THR A 1 312 ? 35.332 70.318 34.293 1.00 49.95 ? 378 THR A CB 1 ATOM 2342 O OG1 . THR A 1 312 ? 34.769 71.253 35.216 1.00 48.98 ? 378 THR A OG1 1 ATOM 2343 C CG2 . THR A 1 312 ? 35.206 68.896 34.853 1.00 45.19 ? 378 THR A CG2 1 ATOM 2344 N N . TRP A 1 313 ? 37.449 71.803 36.005 1.00 39.56 ? 379 TRP A N 1 ATOM 2345 C CA . TRP A 1 313 ? 38.018 71.812 37.343 1.00 38.17 ? 379 TRP A CA 1 ATOM 2346 C C . TRP A 1 313 ? 36.961 71.171 38.239 1.00 37.53 ? 379 TRP A C 1 ATOM 2347 O O . TRP A 1 313 ? 35.786 71.090 37.871 1.00 36.08 ? 379 TRP A O 1 ATOM 2348 C CB . TRP A 1 313 ? 38.302 73.220 37.848 1.00 36.88 ? 379 TRP A CB 1 ATOM 2349 C CG . TRP A 1 313 ? 39.445 73.891 37.153 1.00 38.25 ? 379 TRP A CG 1 ATOM 2350 C CD1 . TRP A 1 313 ? 39.436 74.436 35.900 1.00 41.07 ? 379 TRP A CD1 1 ATOM 2351 C CD2 . TRP A 1 313 ? 40.715 74.224 37.728 1.00 38.23 ? 379 TRP A CD2 1 ATOM 2352 N NE1 . TRP A 1 313 ? 40.628 75.073 35.655 1.00 40.56 ? 379 TRP A NE1 1 ATOM 2353 C CE2 . TRP A 1 313 ? 41.434 74.956 36.758 1.00 42.53 ? 379 TRP A CE2 1 ATOM 2354 C CE3 . TRP A 1 313 ? 41.320 73.967 38.972 1.00 39.52 ? 379 TRP A CE3 1 ATOM 2355 C CZ2 . TRP A 1 313 ? 42.748 75.399 36.977 1.00 42.62 ? 379 TRP A CZ2 1 ATOM 2356 C CZ3 . TRP A 1 313 ? 42.614 74.415 39.197 1.00 41.40 ? 379 TRP A CZ3 1 ATOM 2357 C CH2 . TRP A 1 313 ? 43.314 75.127 38.213 1.00 42.50 ? 379 TRP A CH2 1 ATOM 2358 N N . ALA A 1 314 ? 37.378 70.682 39.391 1.00 32.43 ? 380 ALA A N 1 ATOM 2359 C CA . ALA A 1 314 ? 36.433 70.154 40.376 1.00 30.94 ? 380 ALA A CA 1 ATOM 2360 C C . ALA A 1 314 ? 36.802 70.767 41.721 1.00 33.83 ? 380 ALA A C 1 ATOM 2361 O O . ALA A 1 314 ? 37.970 70.746 42.112 1.00 31.91 ? 380 ALA A O 1 ATOM 2362 C CB . ALA A 1 314 ? 36.485 68.638 40.435 1.00 30.71 ? 380 ALA A CB 1 ATOM 2363 N N . LEU A 1 315 ? 35.811 71.379 42.386 1.00 30.82 ? 381 LEU A N 1 ATOM 2364 C CA . LEU A 1 315 ? 35.984 71.998 43.695 1.00 30.32 ? 381 LEU A CA 1 ATOM 2365 C C . LEU A 1 315 ? 35.428 71.042 44.734 1.00 35.39 ? 381 LEU A C 1 ATOM 2366 O O . LEU A 1 315 ? 34.210 70.944 44.914 1.00 35.21 ? 381 LEU A O 1 ATOM 2367 C CB . LEU A 1 315 ? 35.320 73.393 43.748 1.00 30.27 ? 381 LEU A CB 1 ATOM 2368 C CG . LEU A 1 315 ? 35.780 74.394 42.654 1.00 34.09 ? 381 LEU A CG 1 ATOM 2369 C CD1 . LEU A 1 315 ? 34.870 75.633 42.622 1.00 34.11 ? 381 LEU A CD1 1 ATOM 2370 C CD2 . LEU A 1 315 ? 37.260 74.759 42.795 1.00 30.93 ? 381 LEU A CD2 1 ATOM 2371 N N . GLY A 1 316 ? 36.338 70.262 45.317 1.00 31.60 ? 382 GLY A N 1 ATOM 2372 C CA . GLY A 1 316 ? 36.027 69.262 46.325 1.00 31.17 ? 382 GLY A CA 1 ATOM 2373 C C . GLY A 1 316 ? 36.098 69.763 47.754 1.00 36.04 ? 382 GLY A C 1 ATOM 2374 O O . GLY A 1 316 ? 36.021 70.970 48.004 1.00 35.12 ? 382 GLY A O 1 ATOM 2375 N N . ALA A 1 317 ? 36.275 68.823 48.713 1.00 34.58 ? 383 ALA A N 1 ATOM 2376 C CA . ALA A 1 317 ? 36.335 69.122 50.158 1.00 33.61 ? 383 ALA A CA 1 ATOM 2377 C C . ALA A 1 317 ? 37.309 70.261 50.516 1.00 36.77 ? 383 ALA A C 1 ATOM 2378 O O . ALA A 1 317 ? 37.005 71.035 51.424 1.00 36.62 ? 383 ALA A O 1 ATOM 2379 C CB . ALA A 1 317 ? 36.643 67.867 50.953 1.00 33.62 ? 383 ALA A CB 1 ATOM 2380 N N . THR A 1 318 ? 38.424 70.430 49.741 1.00 33.47 ? 384 THR A N 1 ATOM 2381 C CA . THR A 1 318 ? 39.411 71.504 49.977 1.00 32.60 ? 384 THR A CA 1 ATOM 2382 C C . THR A 1 318 ? 38.751 72.879 49.936 1.00 36.34 ? 384 THR A C 1 ATOM 2383 O O . THR A 1 318 ? 39.070 73.745 50.756 1.00 35.16 ? 384 THR A O 1 ATOM 2384 C CB . THR A 1 318 ? 40.600 71.407 49.005 1.00 36.35 ? 384 THR A CB 1 ATOM 2385 O OG1 . THR A 1 318 ? 41.168 70.105 49.100 1.00 35.50 ? 384 THR A OG1 1 ATOM 2386 C CG2 . THR A 1 318 ? 41.687 72.464 49.288 1.00 30.73 ? 384 THR A CG2 1 ATOM 2387 N N . PHE A 1 319 ? 37.824 73.051 48.975 1.00 33.18 ? 385 PHE A N 1 ATOM 2388 C CA . PHE A 1 319 ? 37.073 74.270 48.737 1.00 32.37 ? 385 PHE A CA 1 ATOM 2389 C C . PHE A 1 319 ? 35.898 74.446 49.707 1.00 36.02 ? 385 PHE A C 1 ATOM 2390 O O . PHE A 1 319 ? 35.738 75.521 50.274 1.00 34.33 ? 385 PHE A O 1 ATOM 2391 C CB . PHE A 1 319 ? 36.608 74.316 47.271 1.00 33.52 ? 385 PHE A CB 1 ATOM 2392 C CG . PHE A 1 319 ? 36.140 75.678 46.844 1.00 33.88 ? 385 PHE A CG 1 ATOM 2393 C CD1 . PHE A 1 319 ? 37.046 76.625 46.384 1.00 34.98 ? 385 PHE A CD1 1 ATOM 2394 C CD2 . PHE A 1 319 ? 34.783 76.022 46.905 1.00 34.17 ? 385 PHE A CD2 1 ATOM 2395 C CE1 . PHE A 1 319 ? 36.608 77.884 45.974 1.00 34.71 ? 385 PHE A CE1 1 ATOM 2396 C CE2 . PHE A 1 319 ? 34.353 77.290 46.531 1.00 35.62 ? 385 PHE A CE2 1 ATOM 2397 C CZ . PHE A 1 319 ? 35.266 78.204 46.054 1.00 33.60 ? 385 PHE A CZ 1 ATOM 2398 N N . ILE A 1 320 ? 35.089 73.394 49.885 1.00 34.31 ? 386 ILE A N 1 ATOM 2399 C CA . ILE A 1 320 ? 33.903 73.386 50.739 1.00 33.25 ? 386 ILE A CA 1 ATOM 2400 C C . ILE A 1 320 ? 34.250 73.644 52.219 1.00 37.90 ? 386 ILE A C 1 ATOM 2401 O O . ILE A 1 320 ? 33.461 74.316 52.903 1.00 38.98 ? 386 ILE A O 1 ATOM 2402 C CB . ILE A 1 320 ? 33.074 72.102 50.499 1.00 35.58 ? 386 ILE A CB 1 ATOM 2403 C CG1 . ILE A 1 320 ? 32.596 72.057 49.009 1.00 35.93 ? 386 ILE A CG1 1 ATOM 2404 C CG2 . ILE A 1 320 ? 31.883 71.986 51.475 1.00 32.77 ? 386 ILE A CG2 1 ATOM 2405 C CD1 . ILE A 1 320 ? 32.282 70.671 48.445 1.00 41.50 ? 386 ILE A CD1 1 ATOM 2406 N N . ARG A 1 321 ? 35.436 73.197 52.702 1.00 31.79 ? 387 ARG A N 1 ATOM 2407 C CA . ARG A 1 321 ? 35.865 73.472 54.085 1.00 29.91 ? 387 ARG A CA 1 ATOM 2408 C C . ARG A 1 321 ? 35.870 74.975 54.348 1.00 33.24 ? 387 ARG A C 1 ATOM 2409 O O . ARG A 1 321 ? 35.377 75.412 55.389 1.00 34.34 ? 387 ARG A O 1 ATOM 2410 C CB . ARG A 1 321 ? 37.267 72.893 54.382 1.00 27.42 ? 387 ARG A CB 1 ATOM 2411 C CG . ARG A 1 321 ? 37.247 71.468 54.859 1.00 29.83 ? 387 ARG A CG 1 ATOM 2412 C CD . ARG A 1 321 ? 38.589 70.995 55.426 1.00 34.97 ? 387 ARG A CD 1 ATOM 2413 N NE . ARG A 1 321 ? 39.646 70.821 54.419 1.00 34.09 ? 387 ARG A NE 1 ATOM 2414 C CZ . ARG A 1 321 ? 39.788 69.747 53.642 1.00 47.58 ? 387 ARG A CZ 1 ATOM 2415 N NH1 . ARG A 1 321 ? 38.918 68.745 53.712 1.00 34.56 ? 387 ARG A NH1 1 ATOM 2416 N NH2 . ARG A 1 321 ? 40.791 69.675 52.777 1.00 29.43 ? 387 ARG A NH2 1 ATOM 2417 N N . LYS A 1 322 ? 36.407 75.753 53.392 1.00 29.40 ? 388 LYS A N 1 ATOM 2418 C CA . LYS A 1 322 ? 36.520 77.205 53.450 1.00 30.39 ? 388 LYS A CA 1 ATOM 2419 C C . LYS A 1 322 ? 35.162 77.887 53.182 1.00 35.09 ? 388 LYS A C 1 ATOM 2420 O O . LYS A 1 322 ? 34.811 78.850 53.867 1.00 34.83 ? 388 LYS A O 1 ATOM 2421 C CB . LYS A 1 322 ? 37.611 77.659 52.452 1.00 35.40 ? 388 LYS A CB 1 ATOM 2422 C CG . LYS A 1 322 ? 37.931 79.149 52.419 1.00 52.11 ? 388 LYS A CG 1 ATOM 2423 C CD . LYS A 1 322 ? 38.939 79.526 53.421 1.00 60.17 ? 388 LYS A CD 1 ATOM 2424 C CE . LYS A 1 322 ? 39.284 80.984 53.315 1.00 62.73 ? 388 LYS A CE 1 ATOM 2425 N NZ . LYS A 1 322 ? 40.313 81.347 54.328 1.00 84.53 ? 388 LYS A NZ 1 ATOM 2426 N N . PHE A 1 323 ? 34.386 77.363 52.215 1.00 31.47 ? 389 PHE A N 1 ATOM 2427 C CA . PHE A 1 323 ? 33.104 77.943 51.812 1.00 29.96 ? 389 PHE A CA 1 ATOM 2428 C C . PHE A 1 323 ? 31.907 77.011 51.940 1.00 33.03 ? 389 PHE A C 1 ATOM 2429 O O . PHE A 1 323 ? 31.761 76.070 51.153 1.00 32.37 ? 389 PHE A O 1 ATOM 2430 C CB . PHE A 1 323 ? 33.185 78.515 50.374 1.00 31.42 ? 389 PHE A CB 1 ATOM 2431 C CG . PHE A 1 323 ? 34.311 79.524 50.195 1.00 32.67 ? 389 PHE A CG 1 ATOM 2432 C CD1 . PHE A 1 323 ? 34.218 80.798 50.741 1.00 32.83 ? 389 PHE A CD1 1 ATOM 2433 C CD2 . PHE A 1 323 ? 35.495 79.168 49.539 1.00 34.54 ? 389 PHE A CD2 1 ATOM 2434 C CE1 . PHE A 1 323 ? 35.287 81.703 50.627 1.00 33.35 ? 389 PHE A CE1 1 ATOM 2435 C CE2 . PHE A 1 323 ? 36.550 80.082 49.390 1.00 36.40 ? 389 PHE A CE2 1 ATOM 2436 C CZ . PHE A 1 323 ? 36.448 81.336 49.950 1.00 34.43 ? 389 PHE A CZ 1 ATOM 2437 N N . TYR A 1 324 ? 31.012 77.323 52.910 1.00 29.88 ? 390 TYR A N 1 ATOM 2438 C CA . TYR A 1 324 ? 29.723 76.650 53.126 1.00 29.34 ? 390 TYR A CA 1 ATOM 2439 C C . TYR A 1 324 ? 28.989 76.716 51.756 1.00 36.37 ? 390 TYR A C 1 ATOM 2440 O O . TYR A 1 324 ? 28.968 77.779 51.130 1.00 37.09 ? 390 TYR A O 1 ATOM 2441 C CB . TYR A 1 324 ? 28.919 77.404 54.214 1.00 29.07 ? 390 TYR A CB 1 ATOM 2442 C CG . TYR A 1 324 ? 27.659 76.679 54.639 1.00 28.90 ? 390 TYR A CG 1 ATOM 2443 C CD1 . TYR A 1 324 ? 26.460 76.838 53.934 1.00 30.53 ? 390 TYR A CD1 1 ATOM 2444 C CD2 . TYR A 1 324 ? 27.667 75.803 55.717 1.00 28.79 ? 390 TYR A CD2 1 ATOM 2445 C CE1 . TYR A 1 324 ? 25.308 76.134 54.295 1.00 29.20 ? 390 TYR A CE1 1 ATOM 2446 C CE2 . TYR A 1 324 ? 26.510 75.134 56.115 1.00 29.15 ? 390 TYR A CE2 1 ATOM 2447 C CZ . TYR A 1 324 ? 25.343 75.283 55.387 1.00 33.12 ? 390 TYR A CZ 1 ATOM 2448 O OH . TYR A 1 324 ? 24.236 74.583 55.769 1.00 33.96 ? 390 TYR A OH 1 ATOM 2449 N N . THR A 1 325 ? 28.488 75.570 51.257 1.00 33.69 ? 391 THR A N 1 ATOM 2450 C CA . THR A 1 325 ? 27.876 75.460 49.927 1.00 34.15 ? 391 THR A CA 1 ATOM 2451 C C . THR A 1 325 ? 26.392 75.069 49.966 1.00 38.92 ? 391 THR A C 1 ATOM 2452 O O . THR A 1 325 ? 26.021 74.106 50.631 1.00 38.66 ? 391 THR A O 1 ATOM 2453 C CB . THR A 1 325 ? 28.708 74.494 49.051 1.00 38.34 ? 391 THR A CB 1 ATOM 2454 O OG1 . THR A 1 325 ? 30.085 74.868 49.130 1.00 36.83 ? 391 THR A OG1 1 ATOM 2455 C CG2 . THR A 1 325 ? 28.254 74.465 47.593 1.00 33.57 ? 391 THR A CG2 1 ATOM 2456 N N . GLU A 1 326 ? 25.563 75.808 49.216 1.00 35.17 ? 392 GLU A N 1 ATOM 2457 C CA . GLU A 1 326 ? 24.130 75.553 49.087 1.00 34.97 ? 392 GLU A CA 1 ATOM 2458 C C . GLU A 1 326 ? 23.830 75.183 47.626 1.00 40.54 ? 392 GLU A C 1 ATOM 2459 O O . GLU A 1 326 ? 24.147 75.948 46.709 1.00 40.91 ? 392 GLU A O 1 ATOM 2460 C CB . GLU A 1 326 ? 23.304 76.776 49.551 1.00 35.77 ? 392 GLU A CB 1 ATOM 2461 C CG . GLU A 1 326 ? 21.806 76.563 49.428 1.00 40.81 ? 392 GLU A CG 1 ATOM 2462 C CD . GLU A 1 326 ? 21.002 77.785 49.796 1.00 60.35 ? 392 GLU A CD 1 ATOM 2463 O OE1 . GLU A 1 326 ? 20.879 78.714 48.966 1.00 59.42 ? 392 GLU A OE1 1 ATOM 2464 O OE2 . GLU A 1 326 ? 20.466 77.791 50.924 1.00 60.66 ? 392 GLU A OE2 1 ATOM 2465 N N . PHE A 1 327 ? 23.249 73.996 47.423 1.00 36.80 ? 393 PHE A N 1 ATOM 2466 C CA . PHE A 1 327 ? 22.892 73.457 46.115 1.00 35.42 ? 393 PHE A CA 1 ATOM 2467 C C . PHE A 1 327 ? 21.413 73.676 45.957 1.00 42.67 ? 393 PHE A C 1 ATOM 2468 O O . PHE A 1 327 ? 20.607 73.075 46.681 1.00 41.62 ? 393 PHE A O 1 ATOM 2469 C CB . PHE A 1 327 ? 23.247 71.966 46.036 1.00 35.53 ? 393 PHE A CB 1 ATOM 2470 C CG . PHE A 1 327 ? 24.728 71.716 46.109 1.00 34.17 ? 393 PHE A CG 1 ATOM 2471 C CD1 . PHE A 1 327 ? 25.512 71.737 44.956 1.00 35.01 ? 393 PHE A CD1 1 ATOM 2472 C CD2 . PHE A 1 327 ? 25.344 71.465 47.325 1.00 34.11 ? 393 PHE A CD2 1 ATOM 2473 C CE1 . PHE A 1 327 ? 26.888 71.508 45.021 1.00 35.47 ? 393 PHE A CE1 1 ATOM 2474 C CE2 . PHE A 1 327 ? 26.725 71.231 47.390 1.00 36.62 ? 393 PHE A CE2 1 ATOM 2475 C CZ . PHE A 1 327 ? 27.490 71.250 46.236 1.00 33.96 ? 393 PHE A CZ 1 ATOM 2476 N N . ASP A 1 328 ? 21.062 74.621 45.069 1.00 41.06 ? 394 ASP A N 1 ATOM 2477 C CA . ASP A 1 328 ? 19.698 75.079 44.861 1.00 40.82 ? 394 ASP A CA 1 ATOM 2478 C C . ASP A 1 328 ? 19.081 74.486 43.586 1.00 46.21 ? 394 ASP A C 1 ATOM 2479 O O . ASP A 1 328 ? 19.415 74.901 42.478 1.00 45.88 ? 394 ASP A O 1 ATOM 2480 C CB . ASP A 1 328 ? 19.711 76.616 44.864 1.00 41.64 ? 394 ASP A CB 1 ATOM 2481 C CG . ASP A 1 328 ? 18.391 77.354 44.785 1.00 46.33 ? 394 ASP A CG 1 ATOM 2482 O OD1 . ASP A 1 328 ? 17.336 76.689 44.596 1.00 46.35 ? 394 ASP A OD1 1 ATOM 2483 O OD2 . ASP A 1 328 ? 18.411 78.593 44.879 1.00 53.59 ? 394 ASP A OD2 1 ATOM 2484 N N . ARG A 1 329 ? 18.178 73.515 43.760 1.00 42.92 ? 395 ARG A N 1 ATOM 2485 C CA . ARG A 1 329 ? 17.504 72.831 42.657 1.00 43.30 ? 395 ARG A CA 1 ATOM 2486 C C . ARG A 1 329 ? 16.422 73.687 42.007 1.00 49.01 ? 395 ARG A C 1 ATOM 2487 O O . ARG A 1 329 ? 16.321 73.694 40.774 1.00 48.64 ? 395 ARG A O 1 ATOM 2488 C CB . ARG A 1 329 ? 16.914 71.479 43.106 1.00 43.31 ? 395 ARG A CB 1 ATOM 2489 C CG . ARG A 1 329 ? 17.916 70.345 43.315 1.00 50.82 ? 395 ARG A CG 1 ATOM 2490 C CD . ARG A 1 329 ? 18.443 69.806 42.003 1.00 64.46 ? 395 ARG A CD 1 ATOM 2491 N NE . ARG A 1 329 ? 17.379 69.392 41.080 1.00 73.22 ? 395 ARG A NE 1 ATOM 2492 C CZ . ARG A 1 329 ? 16.862 68.165 41.017 1.00 81.20 ? 395 ARG A CZ 1 ATOM 2493 N NH1 . ARG A 1 329 ? 17.296 67.208 41.830 1.00 50.81 ? 395 ARG A NH1 1 ATOM 2494 N NH2 . ARG A 1 329 ? 15.912 67.885 40.136 1.00 73.17 ? 395 ARG A NH2 1 ATOM 2495 N N . ARG A 1 330 ? 15.626 74.410 42.829 1.00 46.83 ? 396 ARG A N 1 ATOM 2496 C CA . ARG A 1 330 ? 14.532 75.280 42.386 1.00 46.82 ? 396 ARG A CA 1 ATOM 2497 C C . ARG A 1 330 ? 14.990 76.306 41.335 1.00 51.98 ? 396 ARG A C 1 ATOM 2498 O O . ARG A 1 330 ? 14.337 76.447 40.299 1.00 52.58 ? 396 ARG A O 1 ATOM 2499 C CB . ARG A 1 330 ? 13.860 75.958 43.598 1.00 47.33 ? 396 ARG A CB 1 ATOM 2500 C CG . ARG A 1 330 ? 12.659 76.859 43.268 1.00 54.43 ? 396 ARG A CG 1 ATOM 2501 N N . ASN A 1 331 ? 16.164 76.931 41.562 1.00 47.94 ? 397 ASN A N 1 ATOM 2502 C CA . ASN A 1 331 ? 16.737 77.984 40.732 1.00 46.36 ? 397 ASN A CA 1 ATOM 2503 C C . ASN A 1 331 ? 17.953 77.611 39.885 1.00 50.23 ? 397 ASN A C 1 ATOM 2504 O O . ASN A 1 331 ? 18.488 78.499 39.207 1.00 51.40 ? 397 ASN A O 1 ATOM 2505 C CB . ASN A 1 331 ? 17.085 79.160 41.629 1.00 43.47 ? 397 ASN A CB 1 ATOM 2506 C CG . ASN A 1 331 ? 15.889 79.741 42.345 1.00 53.06 ? 397 ASN A CG 1 ATOM 2507 O OD1 . ASN A 1 331 ? 14.843 80.012 41.747 1.00 55.16 ? 397 ASN A OD1 1 ATOM 2508 N ND2 . ASN A 1 331 ? 16.000 79.925 43.640 1.00 38.06 ? 397 ASN A ND2 1 ATOM 2509 N N . ASN A 1 332 ? 18.392 76.330 39.910 1.00 44.12 ? 398 ASN A N 1 ATOM 2510 C CA . ASN A 1 332 ? 19.580 75.823 39.201 1.00 43.20 ? 398 ASN A CA 1 ATOM 2511 C C . ASN A 1 332 ? 20.789 76.733 39.385 1.00 45.64 ? 398 ASN A C 1 ATOM 2512 O O . ASN A 1 332 ? 21.391 77.229 38.423 1.00 44.37 ? 398 ASN A O 1 ATOM 2513 C CB . ASN A 1 332 ? 19.309 75.496 37.735 1.00 44.07 ? 398 ASN A CB 1 ATOM 2514 C CG . ASN A 1 332 ? 18.300 74.388 37.587 1.00 67.89 ? 398 ASN A CG 1 ATOM 2515 O OD1 . ASN A 1 332 ? 17.104 74.635 37.662 1.00 70.51 ? 398 ASN A OD1 1 ATOM 2516 N ND2 . ASN A 1 332 ? 18.731 73.133 37.597 1.00 55.43 ? 398 ASN A ND2 1 ATOM 2517 N N . ARG A 1 333 ? 21.151 76.918 40.659 1.00 41.64 ? 399 ARG A N 1 ATOM 2518 C CA . ARG A 1 333 ? 22.292 77.734 41.071 1.00 40.77 ? 399 ARG A CA 1 ATOM 2519 C C . ARG A 1 333 ? 22.981 77.128 42.294 1.00 43.54 ? 399 ARG A C 1 ATOM 2520 O O . ARG A 1 333 ? 22.413 76.264 42.965 1.00 42.58 ? 399 ARG A O 1 ATOM 2521 C CB . ARG A 1 333 ? 21.858 79.197 41.335 1.00 38.89 ? 399 ARG A CB 1 ATOM 2522 C CG . ARG A 1 333 ? 20.793 79.326 42.419 1.00 40.76 ? 399 ARG A CG 1 ATOM 2523 C CD . ARG A 1 333 ? 20.413 80.757 42.634 1.00 46.19 ? 399 ARG A CD 1 ATOM 2524 N NE . ARG A 1 333 ? 19.647 80.908 43.873 1.00 45.54 ? 399 ARG A NE 1 ATOM 2525 C CZ . ARG A 1 333 ? 19.303 82.076 44.398 1.00 58.13 ? 399 ARG A CZ 1 ATOM 2526 N NH1 . ARG A 1 333 ? 19.644 83.213 43.792 1.00 41.99 ? 399 ARG A NH1 1 ATOM 2527 N NH2 . ARG A 1 333 ? 18.622 82.121 45.533 1.00 47.28 ? 399 ARG A NH2 1 ATOM 2528 N N . ILE A 1 334 ? 24.200 77.607 42.580 1.00 40.54 ? 400 ILE A N 1 ATOM 2529 C CA . ILE A 1 334 ? 25.024 77.210 43.719 1.00 39.32 ? 400 ILE A CA 1 ATOM 2530 C C . ILE A 1 334 ? 25.379 78.467 44.487 1.00 42.26 ? 400 ILE A C 1 ATOM 2531 O O . ILE A 1 334 ? 25.834 79.443 43.899 1.00 40.25 ? 400 ILE A O 1 ATOM 2532 C CB . ILE A 1 334 ? 26.290 76.382 43.294 1.00 41.08 ? 400 ILE A CB 1 ATOM 2533 C CG1 . ILE A 1 334 ? 25.863 75.037 42.636 1.00 40.70 ? 400 ILE A CG1 1 ATOM 2534 C CG2 . ILE A 1 334 ? 27.239 76.141 44.497 1.00 40.96 ? 400 ILE A CG2 1 ATOM 2535 C CD1 . ILE A 1 334 ? 26.965 74.250 41.907 1.00 34.98 ? 400 ILE A CD1 1 ATOM 2536 N N . GLY A 1 335 ? 25.161 78.432 45.791 1.00 40.37 ? 401 GLY A N 1 ATOM 2537 C CA . GLY A 1 335 ? 25.504 79.547 46.670 1.00 39.07 ? 401 GLY A CA 1 ATOM 2538 C C . GLY A 1 335 ? 26.672 79.206 47.561 1.00 39.95 ? 401 GLY A C 1 ATOM 2539 O O . GLY A 1 335 ? 26.744 78.088 48.068 1.00 38.72 ? 401 GLY A O 1 ATOM 2540 N N . PHE A 1 336 ? 27.600 80.164 47.729 1.00 36.37 ? 402 PHE A N 1 ATOM 2541 C CA . PHE A 1 336 ? 28.767 80.070 48.604 1.00 35.70 ? 402 PHE A CA 1 ATOM 2542 C C . PHE A 1 336 ? 28.754 81.179 49.663 1.00 40.09 ? 402 PHE A C 1 ATOM 2543 O O . PHE A 1 336 ? 28.433 82.330 49.370 1.00 38.89 ? 402 PHE A O 1 ATOM 2544 C CB . PHE A 1 336 ? 30.097 80.145 47.816 1.00 36.93 ? 402 PHE A CB 1 ATOM 2545 C CG . PHE A 1 336 ? 30.368 79.038 46.830 1.00 38.02 ? 402 PHE A CG 1 ATOM 2546 C CD1 . PHE A 1 336 ? 30.538 77.727 47.262 1.00 40.52 ? 402 PHE A CD1 1 ATOM 2547 C CD2 . PHE A 1 336 ? 30.543 79.316 45.473 1.00 39.51 ? 402 PHE A CD2 1 ATOM 2548 C CE1 . PHE A 1 336 ? 30.803 76.702 46.344 1.00 40.44 ? 402 PHE A CE1 1 ATOM 2549 C CE2 . PHE A 1 336 ? 30.831 78.296 44.567 1.00 40.85 ? 402 PHE A CE2 1 ATOM 2550 C CZ . PHE A 1 336 ? 30.956 76.993 45.008 1.00 37.86 ? 402 PHE A CZ 1 ATOM 2551 N N . ALA A 1 337 ? 29.115 80.824 50.886 1.00 37.39 ? 403 ALA A N 1 ATOM 2552 C CA . ALA A 1 337 ? 29.253 81.739 52.012 1.00 37.26 ? 403 ALA A CA 1 ATOM 2553 C C . ALA A 1 337 ? 30.460 81.264 52.808 1.00 38.98 ? 403 ALA A C 1 ATOM 2554 O O . ALA A 1 337 ? 30.797 80.091 52.728 1.00 38.49 ? 403 ALA A O 1 ATOM 2555 C CB . ALA A 1 337 ? 27.997 81.732 52.877 1.00 38.11 ? 403 ALA A CB 1 ATOM 2556 N N . LEU A 1 338 ? 31.124 82.172 53.535 1.00 34.51 ? 404 LEU A N 1 ATOM 2557 C CA . LEU A 1 338 ? 32.296 81.848 54.342 1.00 33.30 ? 404 LEU A CA 1 ATOM 2558 C C . LEU A 1 338 ? 31.883 80.957 55.521 1.00 34.92 ? 404 LEU A C 1 ATOM 2559 O O . LEU A 1 338 ? 31.046 81.358 56.328 1.00 34.38 ? 404 LEU A O 1 ATOM 2560 C CB . LEU A 1 338 ? 32.982 83.146 54.817 1.00 32.69 ? 404 LEU A CB 1 ATOM 2561 C CG . LEU A 1 338 ? 34.312 83.012 55.557 1.00 36.28 ? 404 LEU A CG 1 ATOM 2562 C CD1 . LEU A 1 338 ? 35.412 82.342 54.659 1.00 34.96 ? 404 LEU A CD1 1 ATOM 2563 C CD2 . LEU A 1 338 ? 34.737 84.382 56.146 1.00 36.06 ? 404 LEU A CD2 1 ATOM 2564 N N . ALA A 1 339 ? 32.420 79.737 55.578 1.00 31.77 ? 405 ALA A N 1 ATOM 2565 C CA . ALA A 1 339 ? 32.118 78.788 56.655 1.00 32.07 ? 405 ALA A CA 1 ATOM 2566 C C . ALA A 1 339 ? 32.624 79.264 58.016 1.00 36.52 ? 405 ALA A C 1 ATOM 2567 O O . ALA A 1 339 ? 33.615 80.013 58.105 1.00 34.70 ? 405 ALA A O 1 ATOM 2568 C CB . ALA A 1 339 ? 32.721 77.423 56.346 1.00 32.49 ? 405 ALA A CB 1 ATOM 2569 N N . ARG A 1 340 ? 31.937 78.797 59.074 1.00 34.60 ? 406 ARG A N 1 ATOM 2570 C CA . ARG A 1 340 ? 32.319 79.030 60.465 1.00 40.43 ? 406 ARG A CA 1 ATOM 2571 C C . ARG A 1 340 ? 31.972 77.828 61.396 1.00 54.38 ? 406 ARG A C 1 ATOM 2572 O O . ARG A 1 340 ? 32.680 77.665 62.413 1.00 64.45 ? 406 ARG A O 1 ATOM 2573 C CB . ARG A 1 340 ? 31.764 80.356 60.996 1.00 40.86 ? 406 ARG A CB 1 ATOM 2574 C CG . ARG A 1 340 ? 30.292 80.341 61.341 1.00 41.48 ? 406 ARG A CG 1 ATOM 2575 C CD . ARG A 1 340 ? 29.856 81.685 61.831 1.00 41.77 ? 406 ARG A CD 1 ATOM 2576 N NE . ARG A 1 340 ? 28.470 81.638 62.265 1.00 48.73 ? 406 ARG A NE 1 ATOM 2577 C CZ . ARG A 1 340 ? 27.791 82.681 62.733 1.00 74.74 ? 406 ARG A CZ 1 ATOM 2578 N NH1 . ARG A 1 340 ? 28.381 83.870 62.853 1.00 56.17 ? 406 ARG A NH1 1 ATOM 2579 N NH2 . ARG A 1 340 ? 26.518 82.545 63.091 1.00 68.49 ? 406 ARG A NH2 1 ATOM 2580 O OXT . ARG A 1 340 ? 31.035 77.039 61.093 1.00 54.06 ? 406 ARG A OXT 1 ATOM 2581 N N . LEU B 1 1 ? 26.400 103.571 72.627 1.00 74.05 ? 67 LEU B N 1 ATOM 2582 C CA . LEU B 1 1 ? 26.546 102.262 71.984 1.00 73.32 ? 67 LEU B CA 1 ATOM 2583 C C . LEU B 1 1 ? 25.199 101.678 71.533 1.00 76.82 ? 67 LEU B C 1 ATOM 2584 O O . LEU B 1 1 ? 24.222 101.674 72.296 1.00 76.86 ? 67 LEU B O 1 ATOM 2585 C CB . LEU B 1 1 ? 27.317 101.259 72.900 1.00 73.08 ? 67 LEU B CB 1 ATOM 2586 C CG . LEU B 1 1 ? 27.178 99.732 72.630 1.00 77.57 ? 67 LEU B CG 1 ATOM 2587 C CD1 . LEU B 1 1 ? 28.078 99.273 71.522 1.00 77.37 ? 67 LEU B CD1 1 ATOM 2588 C CD2 . LEU B 1 1 ? 27.490 98.912 73.873 1.00 81.18 ? 67 LEU B CD2 1 ATOM 2589 N N . THR B 1 2 ? 25.172 101.168 70.289 1.00 71.90 ? 68 THR B N 1 ATOM 2590 C CA . THR B 1 2 ? 24.035 100.460 69.702 1.00 70.92 ? 68 THR B CA 1 ATOM 2591 C C . THR B 1 2 ? 24.438 98.978 69.587 1.00 72.87 ? 68 THR B C 1 ATOM 2592 O O . THR B 1 2 ? 25.576 98.672 69.204 1.00 73.21 ? 68 THR B O 1 ATOM 2593 C CB . THR B 1 2 ? 23.632 101.061 68.339 1.00 81.13 ? 68 THR B CB 1 ATOM 2594 O OG1 . THR B 1 2 ? 23.631 102.489 68.421 1.00 85.34 ? 68 THR B OG1 1 ATOM 2595 C CG2 . THR B 1 2 ? 22.265 100.564 67.857 1.00 77.78 ? 68 THR B CG2 1 ATOM 2596 N N . LEU B 1 3 ? 23.515 98.066 69.939 1.00 66.73 ? 69 LEU B N 1 ATOM 2597 C CA . LEU B 1 3 ? 23.768 96.629 69.862 1.00 65.18 ? 69 LEU B CA 1 ATOM 2598 C C . LEU B 1 3 ? 22.809 95.925 68.885 1.00 67.43 ? 69 LEU B C 1 ATOM 2599 O O . LEU B 1 3 ? 21.615 96.234 68.837 1.00 68.19 ? 69 LEU B O 1 ATOM 2600 C CB . LEU B 1 3 ? 23.768 95.954 71.262 1.00 64.68 ? 69 LEU B CB 1 ATOM 2601 C CG . LEU B 1 3 ? 24.906 96.331 72.248 1.00 68.64 ? 69 LEU B CG 1 ATOM 2602 C CD1 . LEU B 1 3 ? 24.642 95.756 73.624 1.00 68.45 ? 69 LEU B CD1 1 ATOM 2603 C CD2 . LEU B 1 3 ? 26.286 95.867 71.753 1.00 69.69 ? 69 LEU B CD2 1 ATOM 2604 N N . GLY B 1 4 ? 23.365 95.016 68.094 1.00 60.79 ? 70 GLY B N 1 ATOM 2605 C CA . GLY B 1 4 ? 22.625 94.220 67.128 1.00 59.49 ? 70 GLY B CA 1 ATOM 2606 C C . GLY B 1 4 ? 22.452 92.803 67.624 1.00 60.38 ? 70 GLY B C 1 ATOM 2607 O O . GLY B 1 4 ? 22.311 92.574 68.831 1.00 57.66 ? 70 GLY B O 1 ATOM 2608 N N . ASN B 1 5 ? 22.437 91.851 66.689 1.00 57.11 ? 71 ASN B N 1 ATOM 2609 C CA . ASN B 1 5 ? 22.252 90.435 66.994 1.00 57.05 ? 71 ASN B CA 1 ATOM 2610 C C . ASN B 1 5 ? 23.251 89.550 66.213 1.00 57.42 ? 71 ASN B C 1 ATOM 2611 O O . ASN B 1 5 ? 23.012 88.349 66.021 1.00 56.99 ? 71 ASN B O 1 ATOM 2612 C CB . ASN B 1 5 ? 20.774 90.015 66.767 1.00 60.38 ? 71 ASN B CB 1 ATOM 2613 C CG . ASN B 1 5 ? 20.319 89.960 65.321 1.00 89.58 ? 71 ASN B CG 1 ATOM 2614 O OD1 . ASN B 1 5 ? 20.724 90.770 64.475 1.00 84.93 ? 71 ASN B OD1 1 ATOM 2615 N ND2 . ASN B 1 5 ? 19.443 89.004 65.015 1.00 83.14 ? 71 ASN B ND2 1 ATOM 2616 N N . THR B 1 6 ? 24.382 90.140 65.787 1.00 50.06 ? 72 THR B N 1 ATOM 2617 C CA . THR B 1 6 ? 25.379 89.356 65.075 1.00 48.41 ? 72 THR B CA 1 ATOM 2618 C C . THR B 1 6 ? 26.712 89.228 65.822 1.00 48.17 ? 72 THR B C 1 ATOM 2619 O O . THR B 1 6 ? 27.078 90.017 66.715 1.00 44.32 ? 72 THR B O 1 ATOM 2620 C CB . THR B 1 6 ? 25.609 89.839 63.626 1.00 56.78 ? 72 THR B CB 1 ATOM 2621 O OG1 . THR B 1 6 ? 26.357 91.049 63.621 1.00 51.42 ? 72 THR B OG1 1 ATOM 2622 C CG2 . THR B 1 6 ? 24.321 89.959 62.805 1.00 56.95 ? 72 THR B CG2 1 ATOM 2623 N N . THR B 1 7 ? 27.406 88.162 65.440 1.00 44.10 ? 73 THR B N 1 ATOM 2624 C CA . THR B 1 7 ? 28.755 87.815 65.830 1.00 43.15 ? 73 THR B CA 1 ATOM 2625 C C . THR B 1 7 ? 29.446 87.462 64.530 1.00 46.08 ? 73 THR B C 1 ATOM 2626 O O . THR B 1 7 ? 28.788 87.096 63.544 1.00 46.84 ? 73 THR B O 1 ATOM 2627 C CB . THR B 1 7 ? 28.819 86.634 66.813 1.00 45.30 ? 73 THR B CB 1 ATOM 2628 O OG1 . THR B 1 7 ? 28.314 85.461 66.186 1.00 47.45 ? 73 THR B OG1 1 ATOM 2629 C CG2 . THR B 1 7 ? 28.122 86.907 68.132 1.00 41.72 ? 73 THR B CG2 1 ATOM 2630 N N . SER B 1 8 ? 30.766 87.517 64.537 1.00 40.95 ? 74 SER B N 1 ATOM 2631 C CA . SER B 1 8 ? 31.573 87.192 63.375 1.00 40.35 ? 74 SER B CA 1 ATOM 2632 C C . SER B 1 8 ? 32.838 86.504 63.820 1.00 44.99 ? 74 SER B C 1 ATOM 2633 O O . SER B 1 8 ? 33.515 86.984 64.731 1.00 45.34 ? 74 SER B O 1 ATOM 2634 C CB . SER B 1 8 ? 31.878 88.457 62.583 1.00 41.30 ? 74 SER B CB 1 ATOM 2635 O OG . SER B 1 8 ? 32.883 88.243 61.609 1.00 47.64 ? 74 SER B OG 1 ATOM 2636 N N . SER B 1 9 ? 33.141 85.353 63.204 1.00 41.67 ? 75 SER B N 1 ATOM 2637 C CA . SER B 1 9 ? 34.314 84.570 63.571 1.00 40.71 ? 75 SER B CA 1 ATOM 2638 C C . SER B 1 9 ? 35.431 84.605 62.495 1.00 42.27 ? 75 SER B C 1 ATOM 2639 O O . SER B 1 9 ? 35.160 84.741 61.301 1.00 39.41 ? 75 SER B O 1 ATOM 2640 C CB . SER B 1 9 ? 33.914 83.147 63.959 1.00 42.53 ? 75 SER B CB 1 ATOM 2641 O OG . SER B 1 9 ? 33.990 82.208 62.900 1.00 56.13 ? 75 SER B OG 1 ATOM 2642 N N . VAL B 1 10 ? 36.696 84.523 62.940 1.00 37.51 ? 76 VAL B N 1 ATOM 2643 C CA . VAL B 1 10 ? 37.853 84.469 62.038 1.00 35.81 ? 76 VAL B CA 1 ATOM 2644 C C . VAL B 1 10 ? 38.693 83.285 62.477 1.00 37.88 ? 76 VAL B C 1 ATOM 2645 O O . VAL B 1 10 ? 39.165 83.265 63.629 1.00 35.68 ? 76 VAL B O 1 ATOM 2646 C CB . VAL B 1 10 ? 38.686 85.785 61.935 1.00 38.32 ? 76 VAL B CB 1 ATOM 2647 C CG1 . VAL B 1 10 ? 39.836 85.633 60.939 1.00 37.90 ? 76 VAL B CG1 1 ATOM 2648 C CG2 . VAL B 1 10 ? 37.810 86.968 61.552 1.00 37.55 ? 76 VAL B CG2 1 ATOM 2649 N N . ILE B 1 11 ? 38.853 82.291 61.561 1.00 33.14 ? 77 ILE B N 1 ATOM 2650 C CA . ILE B 1 11 ? 39.662 81.095 61.794 1.00 33.20 ? 77 ILE B CA 1 ATOM 2651 C C . ILE B 1 11 ? 41.146 81.507 61.770 1.00 36.48 ? 77 ILE B C 1 ATOM 2652 O O . ILE B 1 11 ? 41.584 82.214 60.862 1.00 35.96 ? 77 ILE B O 1 ATOM 2653 C CB . ILE B 1 11 ? 39.350 79.958 60.769 1.00 36.94 ? 77 ILE B CB 1 ATOM 2654 C CG1 . ILE B 1 11 ? 37.853 79.455 60.825 1.00 38.56 ? 77 ILE B CG1 1 ATOM 2655 C CG2 . ILE B 1 11 ? 40.332 78.798 60.866 1.00 36.12 ? 77 ILE B CG2 1 ATOM 2656 C CD1 . ILE B 1 11 ? 37.194 79.210 62.224 1.00 50.27 ? 77 ILE B CD1 1 ATOM 2657 N N . LEU B 1 12 ? 41.914 81.052 62.757 1.00 32.17 ? 78 LEU B N 1 ATOM 2658 C CA . LEU B 1 12 ? 43.336 81.395 62.836 1.00 31.83 ? 78 LEU B CA 1 ATOM 2659 C C . LEU B 1 12 ? 44.198 80.198 62.553 1.00 37.45 ? 78 LEU B C 1 ATOM 2660 O O . LEU B 1 12 ? 43.801 79.078 62.850 1.00 38.56 ? 78 LEU B O 1 ATOM 2661 C CB . LEU B 1 12 ? 43.716 82.009 64.217 1.00 30.68 ? 78 LEU B CB 1 ATOM 2662 C CG . LEU B 1 12 ? 42.843 83.162 64.765 1.00 33.24 ? 78 LEU B CG 1 ATOM 2663 C CD1 . LEU B 1 12 ? 43.283 83.554 66.166 1.00 32.66 ? 78 LEU B CD1 1 ATOM 2664 C CD2 . LEU B 1 12 ? 42.901 84.377 63.866 1.00 32.84 ? 78 LEU B CD2 1 ATOM 2665 N N . THR B 1 13 ? 45.397 80.443 62.009 1.00 34.40 ? 79 THR B N 1 ATOM 2666 C CA . THR B 1 13 ? 46.429 79.444 61.740 1.00 33.68 ? 79 THR B CA 1 ATOM 2667 C C . THR B 1 13 ? 47.403 79.566 62.882 1.00 37.23 ? 79 THR B C 1 ATOM 2668 O O . THR B 1 13 ? 47.779 80.666 63.264 1.00 37.50 ? 79 THR B O 1 ATOM 2669 C CB . THR B 1 13 ? 47.140 79.740 60.383 1.00 37.25 ? 79 THR B CB 1 ATOM 2670 O OG1 . THR B 1 13 ? 46.180 79.672 59.334 1.00 38.41 ? 79 THR B OG1 1 ATOM 2671 C CG2 . THR B 1 13 ? 48.335 78.796 60.091 1.00 27.09 ? 79 THR B CG2 1 ATOM 2672 N N . ASN B 1 14 ? 47.790 78.438 63.430 1.00 35.31 ? 80 ASN B N 1 ATOM 2673 C CA . ASN B 1 14 ? 48.777 78.361 64.480 1.00 35.42 ? 80 ASN B CA 1 ATOM 2674 C C . ASN B 1 14 ? 50.111 77.966 63.840 1.00 43.26 ? 80 ASN B C 1 ATOM 2675 O O . ASN B 1 14 ? 50.293 76.824 63.407 1.00 42.73 ? 80 ASN B O 1 ATOM 2676 C CB . ASN B 1 14 ? 48.372 77.321 65.531 1.00 29.31 ? 80 ASN B CB 1 ATOM 2677 C CG . ASN B 1 14 ? 49.410 77.069 66.574 1.00 33.47 ? 80 ASN B CG 1 ATOM 2678 O OD1 . ASN B 1 14 ? 50.510 77.599 66.523 1.00 29.51 ? 80 ASN B OD1 1 ATOM 2679 N ND2 . ASN B 1 14 ? 49.074 76.291 67.575 1.00 36.06 ? 80 ASN B ND2 1 ATOM 2680 N N . TYR B 1 15 ? 51.058 78.906 63.838 1.00 40.88 ? 81 TYR B N 1 ATOM 2681 C CA . TYR B 1 15 ? 52.399 78.648 63.381 1.00 39.45 ? 81 TYR B CA 1 ATOM 2682 C C . TYR B 1 15 ? 53.316 78.374 64.594 1.00 42.71 ? 81 TYR B C 1 ATOM 2683 O O . TYR B 1 15 ? 53.663 79.310 65.318 1.00 42.20 ? 81 TYR B O 1 ATOM 2684 C CB . TYR B 1 15 ? 52.923 79.821 62.542 1.00 39.93 ? 81 TYR B CB 1 ATOM 2685 C CG . TYR B 1 15 ? 54.361 79.617 62.114 1.00 40.59 ? 81 TYR B CG 1 ATOM 2686 C CD1 . TYR B 1 15 ? 54.688 78.703 61.117 1.00 42.73 ? 81 TYR B CD1 1 ATOM 2687 C CD2 . TYR B 1 15 ? 55.399 80.307 62.735 1.00 40.94 ? 81 TYR B CD2 1 ATOM 2688 C CE1 . TYR B 1 15 ? 56.016 78.491 60.738 1.00 45.80 ? 81 TYR B CE1 1 ATOM 2689 C CE2 . TYR B 1 15 ? 56.728 80.107 62.365 1.00 41.36 ? 81 TYR B CE2 1 ATOM 2690 C CZ . TYR B 1 15 ? 57.032 79.203 61.359 1.00 50.68 ? 81 TYR B CZ 1 ATOM 2691 O OH . TYR B 1 15 ? 58.335 79.006 60.971 1.00 55.11 ? 81 TYR B OH 1 ATOM 2692 N N . MET B 1 16 ? 53.704 77.095 64.802 1.00 39.82 ? 82 MET B N 1 ATOM 2693 C CA . MET B 1 16 ? 54.646 76.632 65.842 1.00 40.87 ? 82 MET B CA 1 ATOM 2694 C C . MET B 1 16 ? 54.365 77.105 67.292 1.00 42.08 ? 82 MET B C 1 ATOM 2695 O O . MET B 1 16 ? 55.317 77.271 68.069 1.00 39.79 ? 82 MET B O 1 ATOM 2696 C CB . MET B 1 16 ? 56.064 77.075 65.449 1.00 44.49 ? 82 MET B CB 1 ATOM 2697 C CG . MET B 1 16 ? 56.647 76.279 64.319 1.00 50.14 ? 82 MET B CG 1 ATOM 2698 S SD . MET B 1 16 ? 58.234 76.930 63.793 1.00 56.52 ? 82 MET B SD 1 ATOM 2699 C CE . MET B 1 16 ? 58.484 75.910 62.451 1.00 53.12 ? 82 MET B CE 1 ATOM 2700 N N . ASP B 1 17 ? 53.077 77.355 67.654 1.00 37.07 ? 83 ASP B N 1 ATOM 2701 C CA . ASP B 1 17 ? 52.682 77.884 68.976 1.00 34.73 ? 83 ASP B CA 1 ATOM 2702 C C . ASP B 1 17 ? 53.263 79.300 69.261 1.00 37.09 ? 83 ASP B C 1 ATOM 2703 O O . ASP B 1 17 ? 53.236 79.730 70.406 1.00 35.95 ? 83 ASP B O 1 ATOM 2704 C CB . ASP B 1 17 ? 53.044 76.912 70.126 1.00 34.82 ? 83 ASP B CB 1 ATOM 2705 C CG . ASP B 1 17 ? 52.307 75.593 70.166 1.00 42.09 ? 83 ASP B CG 1 ATOM 2706 O OD1 . ASP B 1 17 ? 51.175 75.532 69.678 1.00 40.88 ? 83 ASP B OD1 1 ATOM 2707 O OD2 . ASP B 1 17 ? 52.822 74.653 70.783 1.00 56.70 ? 83 ASP B OD2 1 ATOM 2708 N N . THR B 1 18 ? 53.794 80.017 68.240 1.00 32.99 ? 84 THR B N 1 ATOM 2709 C CA . THR B 1 18 ? 54.379 81.348 68.457 1.00 32.52 ? 84 THR B CA 1 ATOM 2710 C C . THR B 1 18 ? 53.732 82.453 67.624 1.00 35.78 ? 84 THR B C 1 ATOM 2711 O O . THR B 1 18 ? 53.903 83.635 67.948 1.00 35.95 ? 84 THR B O 1 ATOM 2712 C CB . THR B 1 18 ? 55.908 81.335 68.271 1.00 41.66 ? 84 THR B CB 1 ATOM 2713 O OG1 . THR B 1 18 ? 56.239 80.924 66.932 1.00 44.73 ? 84 THR B OG1 1 ATOM 2714 C CG2 . THR B 1 18 ? 56.627 80.453 69.331 1.00 34.18 ? 84 THR B CG2 1 ATOM 2715 N N . GLN B 1 19 ? 53.029 82.096 66.545 1.00 30.96 ? 85 GLN B N 1 ATOM 2716 C CA . GLN B 1 19 ? 52.373 83.089 65.693 1.00 31.38 ? 85 GLN B CA 1 ATOM 2717 C C . GLN B 1 19 ? 50.975 82.603 65.351 1.00 36.00 ? 85 GLN B C 1 ATOM 2718 O O . GLN B 1 19 ? 50.824 81.474 64.867 1.00 34.69 ? 85 GLN B O 1 ATOM 2719 C CB . GLN B 1 19 ? 53.181 83.368 64.409 1.00 32.31 ? 85 GLN B CB 1 ATOM 2720 C CG . GLN B 1 19 ? 54.634 83.805 64.631 1.00 44.70 ? 85 GLN B CG 1 ATOM 2721 C CD . GLN B 1 19 ? 55.386 83.976 63.328 1.00 49.59 ? 85 GLN B CD 1 ATOM 2722 O OE1 . GLN B 1 19 ? 54.845 84.424 62.302 1.00 41.11 ? 85 GLN B OE1 1 ATOM 2723 N NE2 . GLN B 1 19 ? 56.670 83.662 63.360 1.00 29.92 ? 85 GLN B NE2 1 ATOM 2724 N N . TYR B 1 20 ? 49.951 83.430 65.665 1.00 32.02 ? 86 TYR B N 1 ATOM 2725 C CA . TYR B 1 20 ? 48.552 83.111 65.380 1.00 31.30 ? 86 TYR B CA 1 ATOM 2726 C C . TYR B 1 20 ? 48.014 84.213 64.497 1.00 35.43 ? 86 TYR B C 1 ATOM 2727 O O . TYR B 1 20 ? 48.069 85.386 64.861 1.00 35.30 ? 86 TYR B O 1 ATOM 2728 C CB . TYR B 1 20 ? 47.717 82.975 66.673 1.00 30.85 ? 86 TYR B CB 1 ATOM 2729 C CG . TYR B 1 20 ? 48.099 81.803 67.548 1.00 27.76 ? 86 TYR B CG 1 ATOM 2730 C CD1 . TYR B 1 20 ? 49.196 81.872 68.401 1.00 26.83 ? 86 TYR B CD1 1 ATOM 2731 C CD2 . TYR B 1 20 ? 47.333 80.634 67.558 1.00 27.61 ? 86 TYR B CD2 1 ATOM 2732 C CE1 . TYR B 1 20 ? 49.545 80.792 69.215 1.00 26.96 ? 86 TYR B CE1 1 ATOM 2733 C CE2 . TYR B 1 20 ? 47.659 79.560 68.387 1.00 26.75 ? 86 TYR B CE2 1 ATOM 2734 C CZ . TYR B 1 20 ? 48.763 79.645 69.218 1.00 29.21 ? 86 TYR B CZ 1 ATOM 2735 O OH . TYR B 1 20 ? 49.099 78.590 70.038 1.00 29.12 ? 86 TYR B OH 1 ATOM 2736 N N . TYR B 1 21 ? 47.554 83.843 63.307 1.00 33.02 ? 87 TYR B N 1 ATOM 2737 C CA . TYR B 1 21 ? 47.072 84.803 62.330 1.00 32.86 ? 87 TYR B CA 1 ATOM 2738 C C . TYR B 1 21 ? 45.873 84.300 61.557 1.00 38.46 ? 87 TYR B C 1 ATOM 2739 O O . TYR B 1 21 ? 45.705 83.098 61.379 1.00 39.78 ? 87 TYR B O 1 ATOM 2740 C CB . TYR B 1 21 ? 48.205 85.204 61.352 1.00 34.59 ? 87 TYR B CB 1 ATOM 2741 C CG . TYR B 1 21 ? 48.939 84.035 60.724 1.00 36.15 ? 87 TYR B CG 1 ATOM 2742 C CD1 . TYR B 1 21 ? 48.506 83.477 59.528 1.00 37.28 ? 87 TYR B CD1 1 ATOM 2743 C CD2 . TYR B 1 21 ? 50.072 83.484 61.334 1.00 37.31 ? 87 TYR B CD2 1 ATOM 2744 C CE1 . TYR B 1 21 ? 49.183 82.399 58.954 1.00 38.45 ? 87 TYR B CE1 1 ATOM 2745 C CE2 . TYR B 1 21 ? 50.734 82.386 60.783 1.00 38.20 ? 87 TYR B CE2 1 ATOM 2746 C CZ . TYR B 1 21 ? 50.295 81.860 59.592 1.00 45.75 ? 87 TYR B CZ 1 ATOM 2747 O OH . TYR B 1 21 ? 51.009 80.815 59.082 1.00 49.22 ? 87 TYR B OH 1 ATOM 2748 N N . GLY B 1 22 ? 45.066 85.234 61.082 1.00 32.90 ? 88 GLY B N 1 ATOM 2749 C CA . GLY B 1 22 ? 43.882 84.949 60.299 1.00 32.80 ? 88 GLY B CA 1 ATOM 2750 C C . GLY B 1 22 ? 43.843 85.877 59.129 1.00 40.14 ? 88 GLY B C 1 ATOM 2751 O O . GLY B 1 22 ? 44.765 86.670 58.961 1.00 41.42 ? 88 GLY B O 1 ATOM 2752 N N . GLU B 1 23 ? 42.764 85.839 58.358 1.00 37.17 ? 89 GLU B N 1 ATOM 2753 C CA . GLU B 1 23 ? 42.648 86.648 57.156 1.00 36.84 ? 89 GLU B CA 1 ATOM 2754 C C . GLU B 1 23 ? 41.757 87.861 57.264 1.00 39.99 ? 89 GLU B C 1 ATOM 2755 O O . GLU B 1 23 ? 40.691 87.813 57.895 1.00 38.89 ? 89 GLU B O 1 ATOM 2756 C CB . GLU B 1 23 ? 42.170 85.782 55.945 1.00 38.31 ? 89 GLU B CB 1 ATOM 2757 C CG . GLU B 1 23 ? 42.880 84.446 55.738 1.00 55.69 ? 89 GLU B CG 1 ATOM 2758 C CD . GLU B 1 23 ? 44.395 84.442 55.866 1.00 85.86 ? 89 GLU B CD 1 ATOM 2759 O OE1 . GLU B 1 23 ? 45.052 85.154 55.070 1.00 94.42 ? 89 GLU B OE1 1 ATOM 2760 O OE2 . GLU B 1 23 ? 44.925 83.719 56.744 1.00 72.95 ? 89 GLU B OE2 1 ATOM 2761 N N . ILE B 1 24 ? 42.155 88.923 56.544 1.00 36.29 ? 90 ILE B N 1 ATOM 2762 C CA . ILE B 1 24 ? 41.362 90.137 56.314 1.00 36.75 ? 90 ILE B CA 1 ATOM 2763 C C . ILE B 1 24 ? 41.457 90.458 54.824 1.00 43.88 ? 90 ILE B C 1 ATOM 2764 O O . ILE B 1 24 ? 42.478 90.174 54.193 1.00 43.54 ? 90 ILE B O 1 ATOM 2765 C CB . ILE B 1 24 ? 41.677 91.375 57.217 1.00 38.65 ? 90 ILE B CB 1 ATOM 2766 C CG1 . ILE B 1 24 ? 43.115 91.936 56.958 1.00 37.92 ? 90 ILE B CG1 1 ATOM 2767 C CG2 . ILE B 1 24 ? 41.413 91.050 58.711 1.00 39.08 ? 90 ILE B CG2 1 ATOM 2768 C CD1 . ILE B 1 24 ? 43.397 93.380 57.431 1.00 33.39 ? 90 ILE B CD1 1 ATOM 2769 N N . GLY B 1 25 ? 40.392 91.011 54.274 1.00 41.76 ? 91 GLY B N 1 ATOM 2770 C CA . GLY B 1 25 ? 40.382 91.438 52.883 1.00 42.09 ? 91 GLY B CA 1 ATOM 2771 C C . GLY B 1 25 ? 40.347 92.952 52.824 1.00 46.13 ? 91 GLY B C 1 ATOM 2772 O O . GLY B 1 25 ? 39.533 93.563 53.520 1.00 44.53 ? 91 GLY B O 1 ATOM 2773 N N . ILE B 1 26 ? 41.255 93.571 52.041 1.00 44.76 ? 92 ILE B N 1 ATOM 2774 C CA . ILE B 1 26 ? 41.324 95.038 51.886 1.00 45.99 ? 92 ILE B CA 1 ATOM 2775 C C . ILE B 1 26 ? 41.092 95.438 50.426 1.00 53.33 ? 92 ILE B C 1 ATOM 2776 O O . ILE B 1 26 ? 41.748 94.896 49.533 1.00 53.20 ? 92 ILE B O 1 ATOM 2777 C CB . ILE B 1 26 ? 42.637 95.682 52.455 1.00 48.60 ? 92 ILE B CB 1 ATOM 2778 C CG1 . ILE B 1 26 ? 43.046 95.084 53.836 1.00 48.81 ? 92 ILE B CG1 1 ATOM 2779 C CG2 . ILE B 1 26 ? 42.521 97.232 52.504 1.00 47.23 ? 92 ILE B CG2 1 ATOM 2780 C CD1 . ILE B 1 26 ? 44.347 95.602 54.369 1.00 49.36 ? 92 ILE B CD1 1 ATOM 2781 N N . GLY B 1 27 ? 40.186 96.392 50.210 1.00 51.92 ? 93 GLY B N 1 ATOM 2782 C CA . GLY B 1 27 ? 39.875 96.919 48.887 1.00 53.13 ? 93 GLY B CA 1 ATOM 2783 C C . GLY B 1 27 ? 38.716 96.297 48.131 1.00 59.24 ? 93 GLY B C 1 ATOM 2784 O O . GLY B 1 27 ? 38.035 95.405 48.643 1.00 59.79 ? 93 GLY B O 1 ATOM 2785 N N . THR B 1 28 ? 38.466 96.825 46.908 1.00 55.87 ? 94 THR B N 1 ATOM 2786 C CA . THR B 1 28 ? 37.450 96.392 45.938 1.00 55.37 ? 94 THR B CA 1 ATOM 2787 C C . THR B 1 28 ? 38.138 96.167 44.570 1.00 60.25 ? 94 THR B C 1 ATOM 2788 O O . THR B 1 28 ? 38.519 97.150 43.929 1.00 61.23 ? 94 THR B O 1 ATOM 2789 C CB . THR B 1 28 ? 36.283 97.385 45.850 1.00 59.16 ? 94 THR B CB 1 ATOM 2790 O OG1 . THR B 1 28 ? 35.807 97.677 47.156 1.00 59.25 ? 94 THR B OG1 1 ATOM 2791 C CG2 . THR B 1 28 ? 35.129 96.855 45.011 1.00 54.89 ? 94 THR B CG2 1 ATOM 2792 N N . PRO B 1 29 ? 38.326 94.906 44.105 1.00 56.66 ? 95 PRO B N 1 ATOM 2793 C CA . PRO B 1 29 ? 38.000 93.633 44.785 1.00 56.75 ? 95 PRO B CA 1 ATOM 2794 C C . PRO B 1 29 ? 38.930 93.418 45.999 1.00 61.87 ? 95 PRO B C 1 ATOM 2795 O O . PRO B 1 29 ? 39.993 94.058 46.059 1.00 62.47 ? 95 PRO B O 1 ATOM 2796 C CB . PRO B 1 29 ? 38.196 92.585 43.678 1.00 58.04 ? 95 PRO B CB 1 ATOM 2797 C CG . PRO B 1 29 ? 39.258 93.171 42.793 1.00 62.32 ? 95 PRO B CG 1 ATOM 2798 C CD . PRO B 1 29 ? 39.031 94.673 42.827 1.00 58.21 ? 95 PRO B CD 1 ATOM 2799 N N . PRO B 1 30 ? 38.570 92.582 47.003 1.00 58.06 ? 96 PRO B N 1 ATOM 2800 C CA . PRO B 1 30 ? 39.470 92.435 48.160 1.00 56.90 ? 96 PRO B CA 1 ATOM 2801 C C . PRO B 1 30 ? 40.820 91.777 47.859 1.00 57.35 ? 96 PRO B C 1 ATOM 2802 O O . PRO B 1 30 ? 40.892 90.855 47.058 1.00 57.82 ? 96 PRO B O 1 ATOM 2803 C CB . PRO B 1 30 ? 38.640 91.631 49.174 1.00 58.76 ? 96 PRO B CB 1 ATOM 2804 C CG . PRO B 1 30 ? 37.607 90.947 48.385 1.00 63.57 ? 96 PRO B CG 1 ATOM 2805 C CD . PRO B 1 30 ? 37.340 91.772 47.162 1.00 59.61 ? 96 PRO B CD 1 ATOM 2806 N N . GLN B 1 31 ? 41.891 92.317 48.469 1.00 50.66 ? 97 GLN B N 1 ATOM 2807 C CA . GLN B 1 31 ? 43.260 91.781 48.445 1.00 48.89 ? 97 GLN B CA 1 ATOM 2808 C C . GLN B 1 31 ? 43.398 91.183 49.850 1.00 51.35 ? 97 GLN B C 1 ATOM 2809 O O . GLN B 1 31 ? 43.055 91.858 50.820 1.00 51.65 ? 97 GLN B O 1 ATOM 2810 C CB . GLN B 1 31 ? 44.295 92.889 48.221 1.00 49.24 ? 97 GLN B CB 1 ATOM 2811 C CG . GLN B 1 31 ? 44.153 93.579 46.881 1.00 58.12 ? 97 GLN B CG 1 ATOM 2812 C CD . GLN B 1 31 ? 45.004 94.816 46.773 1.00 54.56 ? 97 GLN B CD 1 ATOM 2813 O OE1 . GLN B 1 31 ? 46.196 94.821 47.113 1.00 44.18 ? 97 GLN B OE1 1 ATOM 2814 N NE2 . GLN B 1 31 ? 44.392 95.896 46.296 1.00 38.68 ? 97 GLN B NE2 1 ATOM 2815 N N . THR B 1 32 ? 43.799 89.910 49.965 1.00 46.60 ? 98 THR B N 1 ATOM 2816 C CA . THR B 1 32 ? 43.829 89.231 51.264 1.00 45.38 ? 98 THR B CA 1 ATOM 2817 C C . THR B 1 32 ? 45.187 89.240 51.943 1.00 47.76 ? 98 THR B C 1 ATOM 2818 O O . THR B 1 32 ? 46.225 89.111 51.287 1.00 47.63 ? 98 THR B O 1 ATOM 2819 C CB . THR B 1 32 ? 43.270 87.804 51.166 1.00 55.00 ? 98 THR B CB 1 ATOM 2820 O OG1 . THR B 1 32 ? 44.131 87.011 50.348 1.00 62.51 ? 98 THR B OG1 1 ATOM 2821 C CG2 . THR B 1 32 ? 41.822 87.766 50.643 1.00 45.81 ? 98 THR B CG2 1 ATOM 2822 N N . PHE B 1 33 ? 45.167 89.400 53.281 1.00 43.41 ? 99 PHE B N 1 ATOM 2823 C CA . PHE B 1 33 ? 46.379 89.415 54.115 1.00 42.81 ? 99 PHE B CA 1 ATOM 2824 C C . PHE B 1 33 ? 46.234 88.495 55.291 1.00 43.79 ? 99 PHE B C 1 ATOM 2825 O O . PHE B 1 33 ? 45.123 88.290 55.769 1.00 41.94 ? 99 PHE B O 1 ATOM 2826 C CB . PHE B 1 33 ? 46.680 90.847 54.606 1.00 44.63 ? 99 PHE B CB 1 ATOM 2827 C CG . PHE B 1 33 ? 46.966 91.771 53.458 1.00 46.31 ? 99 PHE B CG 1 ATOM 2828 C CD1 . PHE B 1 33 ? 48.221 91.793 52.859 1.00 48.22 ? 99 PHE B CD1 1 ATOM 2829 C CD2 . PHE B 1 33 ? 45.962 92.557 52.917 1.00 49.40 ? 99 PHE B CD2 1 ATOM 2830 C CE1 . PHE B 1 33 ? 48.467 92.599 51.752 1.00 49.32 ? 99 PHE B CE1 1 ATOM 2831 C CE2 . PHE B 1 33 ? 46.209 93.359 51.800 1.00 52.04 ? 99 PHE B CE2 1 ATOM 2832 C CZ . PHE B 1 33 ? 47.459 93.370 51.230 1.00 49.24 ? 99 PHE B CZ 1 ATOM 2833 N N . LYS B 1 34 ? 47.364 87.942 55.746 1.00 39.61 ? 100 LYS B N 1 ATOM 2834 C CA . LYS B 1 34 ? 47.511 87.134 56.958 1.00 38.04 ? 100 LYS B CA 1 ATOM 2835 C C . LYS B 1 34 ? 47.856 88.153 58.055 1.00 41.71 ? 100 LYS B C 1 ATOM 2836 O O . LYS B 1 34 ? 48.865 88.849 57.960 1.00 40.08 ? 100 LYS B O 1 ATOM 2837 C CB . LYS B 1 34 ? 48.644 86.107 56.803 1.00 39.16 ? 100 LYS B CB 1 ATOM 2838 C CG . LYS B 1 34 ? 48.323 85.010 55.788 1.00 40.06 ? 100 LYS B CG 1 ATOM 2839 C CD . LYS B 1 34 ? 49.553 84.209 55.427 1.00 52.22 ? 100 LYS B CD 1 ATOM 2840 C CE . LYS B 1 34 ? 49.280 83.351 54.217 1.00 66.16 ? 100 LYS B CE 1 ATOM 2841 N NZ . LYS B 1 34 ? 50.496 82.624 53.776 1.00 81.93 ? 100 LYS B NZ 1 ATOM 2842 N N . VAL B 1 35 ? 46.983 88.311 59.045 1.00 38.58 ? 101 VAL B N 1 ATOM 2843 C CA . VAL B 1 35 ? 47.206 89.300 60.111 1.00 38.05 ? 101 VAL B CA 1 ATOM 2844 C C . VAL B 1 35 ? 47.125 88.689 61.522 1.00 40.66 ? 101 VAL B C 1 ATOM 2845 O O . VAL B 1 35 ? 46.355 87.756 61.743 1.00 40.10 ? 101 VAL B O 1 ATOM 2846 C CB . VAL B 1 35 ? 46.276 90.543 59.968 1.00 41.39 ? 101 VAL B CB 1 ATOM 2847 C CG1 . VAL B 1 35 ? 46.608 91.341 58.708 1.00 40.61 ? 101 VAL B CG1 1 ATOM 2848 C CG2 . VAL B 1 35 ? 44.796 90.141 59.985 1.00 41.33 ? 101 VAL B CG2 1 ATOM 2849 N N . VAL B 1 36 ? 47.917 89.230 62.462 1.00 36.26 ? 102 VAL B N 1 ATOM 2850 C CA . VAL B 1 36 ? 47.857 88.887 63.883 1.00 36.06 ? 102 VAL B CA 1 ATOM 2851 C C . VAL B 1 36 ? 46.821 89.870 64.474 1.00 37.66 ? 102 VAL B C 1 ATOM 2852 O O . VAL B 1 36 ? 46.883 91.079 64.194 1.00 35.72 ? 102 VAL B O 1 ATOM 2853 C CB . VAL B 1 36 ? 49.237 89.060 64.588 1.00 40.27 ? 102 VAL B CB 1 ATOM 2854 C CG1 . VAL B 1 36 ? 49.131 88.857 66.107 1.00 39.50 ? 102 VAL B CG1 1 ATOM 2855 C CG2 . VAL B 1 36 ? 50.281 88.123 63.999 1.00 39.91 ? 102 VAL B CG2 1 ATOM 2856 N N . PHE B 1 37 ? 45.849 89.349 65.242 1.00 33.37 ? 103 PHE B N 1 ATOM 2857 C CA . PHE B 1 37 ? 44.847 90.187 65.917 1.00 31.59 ? 103 PHE B CA 1 ATOM 2858 C C . PHE B 1 37 ? 45.465 90.417 67.296 1.00 36.16 ? 103 PHE B C 1 ATOM 2859 O O . PHE B 1 37 ? 45.621 89.490 68.095 1.00 34.61 ? 103 PHE B O 1 ATOM 2860 C CB . PHE B 1 37 ? 43.474 89.513 65.925 1.00 32.08 ? 103 PHE B CB 1 ATOM 2861 C CG . PHE B 1 37 ? 42.909 89.310 64.536 1.00 33.16 ? 103 PHE B CG 1 ATOM 2862 C CD1 . PHE B 1 37 ? 43.211 88.164 63.804 1.00 35.24 ? 103 PHE B CD1 1 ATOM 2863 C CD2 . PHE B 1 37 ? 42.058 90.254 63.965 1.00 35.00 ? 103 PHE B CD2 1 ATOM 2864 C CE1 . PHE B 1 37 ? 42.690 87.971 62.516 1.00 36.45 ? 103 PHE B CE1 1 ATOM 2865 C CE2 . PHE B 1 37 ? 41.510 90.048 62.682 1.00 37.90 ? 103 PHE B CE2 1 ATOM 2866 C CZ . PHE B 1 37 ? 41.847 88.914 61.961 1.00 36.10 ? 103 PHE B CZ 1 ATOM 2867 N N . ASP B 1 38 ? 45.953 91.637 67.496 1.00 34.63 ? 104 ASP B N 1 ATOM 2868 C CA . ASP B 1 38 ? 46.803 91.994 68.623 1.00 35.33 ? 104 ASP B CA 1 ATOM 2869 C C . ASP B 1 38 ? 46.214 92.983 69.650 1.00 40.72 ? 104 ASP B C 1 ATOM 2870 O O . ASP B 1 38 ? 46.081 94.161 69.349 1.00 42.34 ? 104 ASP B O 1 ATOM 2871 C CB . ASP B 1 38 ? 48.109 92.531 68.013 1.00 36.58 ? 104 ASP B CB 1 ATOM 2872 C CG . ASP B 1 38 ? 49.160 93.020 68.965 1.00 49.17 ? 104 ASP B CG 1 ATOM 2873 O OD1 . ASP B 1 38 ? 49.262 92.465 70.085 1.00 51.46 ? 104 ASP B OD1 1 ATOM 2874 O OD2 . ASP B 1 38 ? 49.910 93.918 68.584 1.00 55.55 ? 104 ASP B OD2 1 ATOM 2875 N N . THR B 1 39 ? 45.955 92.517 70.888 1.00 36.65 ? 105 THR B N 1 ATOM 2876 C CA . THR B 1 39 ? 45.442 93.378 71.968 1.00 36.35 ? 105 THR B CA 1 ATOM 2877 C C . THR B 1 39 ? 46.528 94.305 72.544 1.00 41.46 ? 105 THR B C 1 ATOM 2878 O O . THR B 1 39 ? 46.194 95.307 73.178 1.00 40.68 ? 105 THR B O 1 ATOM 2879 C CB . THR B 1 39 ? 44.733 92.577 73.057 1.00 37.57 ? 105 THR B CB 1 ATOM 2880 O OG1 . THR B 1 39 ? 45.651 91.611 73.579 1.00 34.99 ? 105 THR B OG1 1 ATOM 2881 C CG2 . THR B 1 39 ? 43.430 91.928 72.558 1.00 35.19 ? 105 THR B CG2 1 ATOM 2882 N N . GLY B 1 40 ? 47.800 93.985 72.280 1.00 38.72 ? 106 GLY B N 1 ATOM 2883 C CA . GLY B 1 40 ? 48.931 94.794 72.717 1.00 38.77 ? 106 GLY B CA 1 ATOM 2884 C C . GLY B 1 40 ? 49.296 95.963 71.808 1.00 42.54 ? 106 GLY B C 1 ATOM 2885 O O . GLY B 1 40 ? 50.341 96.564 72.012 1.00 43.08 ? 106 GLY B O 1 ATOM 2886 N N . SER B 1 41 ? 48.465 96.287 70.788 1.00 38.97 ? 107 SER B N 1 ATOM 2887 C CA . SER B 1 41 ? 48.642 97.412 69.836 1.00 38.61 ? 107 SER B CA 1 ATOM 2888 C C . SER B 1 41 ? 47.276 97.849 69.303 1.00 42.46 ? 107 SER B C 1 ATOM 2889 O O . SER B 1 41 ? 46.315 97.118 69.494 1.00 40.93 ? 107 SER B O 1 ATOM 2890 C CB . SER B 1 41 ? 49.635 97.078 68.718 1.00 41.41 ? 107 SER B CB 1 ATOM 2891 O OG . SER B 1 41 ? 49.071 96.286 67.685 1.00 51.67 ? 107 SER B OG 1 ATOM 2892 N N . SER B 1 42 ? 47.173 99.044 68.675 1.00 40.88 ? 108 SER B N 1 ATOM 2893 C CA . SER B 1 42 ? 45.887 99.610 68.246 1.00 40.59 ? 108 SER B CA 1 ATOM 2894 C C . SER B 1 42 ? 45.803 100.042 66.782 1.00 45.06 ? 108 SER B C 1 ATOM 2895 O O . SER B 1 42 ? 44.785 100.625 66.369 1.00 45.41 ? 108 SER B O 1 ATOM 2896 C CB . SER B 1 42 ? 45.529 100.798 69.137 1.00 45.03 ? 108 SER B CB 1 ATOM 2897 O OG . SER B 1 42 ? 45.781 100.574 70.515 1.00 52.14 ? 108 SER B OG 1 ATOM 2898 N N . ASN B 1 43 ? 46.858 99.784 65.996 1.00 40.89 ? 109 ASN B N 1 ATOM 2899 C CA . ASN B 1 43 ? 46.851 100.193 64.594 1.00 40.50 ? 109 ASN B CA 1 ATOM 2900 C C . ASN B 1 43 ? 46.731 99.016 63.669 1.00 43.57 ? 109 ASN B C 1 ATOM 2901 O O . ASN B 1 43 ? 47.166 97.919 64.009 1.00 42.59 ? 109 ASN B O 1 ATOM 2902 C CB . ASN B 1 43 ? 48.104 101.012 64.238 1.00 42.68 ? 109 ASN B CB 1 ATOM 2903 C CG . ASN B 1 43 ? 48.181 102.358 64.910 1.00 58.90 ? 109 ASN B CG 1 ATOM 2904 O OD1 . ASN B 1 43 ? 48.464 102.465 66.103 1.00 55.43 ? 109 ASN B OD1 1 ATOM 2905 N ND2 . ASN B 1 43 ? 47.984 103.411 64.146 1.00 50.50 ? 109 ASN B ND2 1 ATOM 2906 N N . VAL B 1 44 ? 46.114 99.245 62.498 1.00 39.72 ? 110 VAL B N 1 ATOM 2907 C CA . VAL B 1 44 ? 45.996 98.252 61.442 1.00 38.83 ? 110 VAL B CA 1 ATOM 2908 C C . VAL B 1 44 ? 47.092 98.633 60.439 1.00 46.05 ? 110 VAL B C 1 ATOM 2909 O O . VAL B 1 44 ? 47.257 99.815 60.125 1.00 47.03 ? 110 VAL B O 1 ATOM 2910 C CB . VAL B 1 44 ? 44.590 98.243 60.778 1.00 39.79 ? 110 VAL B CB 1 ATOM 2911 C CG1 . VAL B 1 44 ? 44.544 97.283 59.588 1.00 38.72 ? 110 VAL B CG1 1 ATOM 2912 C CG2 . VAL B 1 44 ? 43.492 97.905 61.786 1.00 38.85 ? 110 VAL B CG2 1 ATOM 2913 N N . TRP B 1 45 ? 47.869 97.652 59.982 1.00 42.65 ? 111 TRP B N 1 ATOM 2914 C CA . TRP B 1 45 ? 48.892 97.864 58.971 1.00 41.92 ? 111 TRP B CA 1 ATOM 2915 C C . TRP B 1 45 ? 49.132 96.601 58.183 1.00 48.37 ? 111 TRP B C 1 ATOM 2916 O O . TRP B 1 45 ? 49.028 95.503 58.729 1.00 48.24 ? 111 TRP B O 1 ATOM 2917 C CB . TRP B 1 45 ? 50.212 98.458 59.536 1.00 39.91 ? 111 TRP B CB 1 ATOM 2918 C CG . TRP B 1 45 ? 51.045 97.545 60.384 1.00 40.90 ? 111 TRP B CG 1 ATOM 2919 C CD1 . TRP B 1 45 ? 51.098 97.518 61.748 1.00 43.92 ? 111 TRP B CD1 1 ATOM 2920 C CD2 . TRP B 1 45 ? 52.013 96.582 59.926 1.00 40.72 ? 111 TRP B CD2 1 ATOM 2921 N NE1 . TRP B 1 45 ? 52.030 96.591 62.172 1.00 43.00 ? 111 TRP B NE1 1 ATOM 2922 C CE2 . TRP B 1 45 ? 52.590 95.989 61.075 1.00 44.16 ? 111 TRP B CE2 1 ATOM 2923 C CE3 . TRP B 1 45 ? 52.433 96.145 58.653 1.00 41.83 ? 111 TRP B CE3 1 ATOM 2924 C CZ2 . TRP B 1 45 ? 53.565 94.993 60.991 1.00 43.40 ? 111 TRP B CZ2 1 ATOM 2925 C CZ3 . TRP B 1 45 ? 53.394 95.155 58.570 1.00 43.17 ? 111 TRP B CZ3 1 ATOM 2926 C CH2 . TRP B 1 45 ? 53.952 94.591 59.729 1.00 43.96 ? 111 TRP B CH2 1 ATOM 2927 N N . VAL B 1 46 ? 49.492 96.761 56.905 1.00 46.46 ? 112 VAL B N 1 ATOM 2928 C CA . VAL B 1 46 ? 49.864 95.692 55.979 1.00 46.36 ? 112 VAL B CA 1 ATOM 2929 C C . VAL B 1 46 ? 51.070 96.199 55.146 1.00 51.63 ? 112 VAL B C 1 ATOM 2930 O O . VAL B 1 46 ? 51.219 97.424 55.005 1.00 50.13 ? 112 VAL B O 1 ATOM 2931 C CB . VAL B 1 46 ? 48.690 95.255 55.060 1.00 49.65 ? 112 VAL B CB 1 ATOM 2932 C CG1 . VAL B 1 46 ? 47.651 94.427 55.816 1.00 48.93 ? 112 VAL B CG1 1 ATOM 2933 C CG2 . VAL B 1 46 ? 48.049 96.443 54.350 1.00 49.46 ? 112 VAL B CG2 1 ATOM 2934 N N . PRO B 1 47 ? 51.920 95.313 54.553 1.00 49.22 ? 113 PRO B N 1 ATOM 2935 C CA . PRO B 1 47 ? 53.001 95.814 53.697 1.00 49.16 ? 113 PRO B CA 1 ATOM 2936 C C . PRO B 1 47 ? 52.411 96.466 52.435 1.00 54.83 ? 113 PRO B C 1 ATOM 2937 O O . PRO B 1 47 ? 51.345 96.053 51.959 1.00 53.58 ? 113 PRO B O 1 ATOM 2938 C CB . PRO B 1 47 ? 53.821 94.547 53.392 1.00 50.62 ? 113 PRO B CB 1 ATOM 2939 C CG . PRO B 1 47 ? 53.387 93.533 54.404 1.00 54.48 ? 113 PRO B CG 1 ATOM 2940 C CD . PRO B 1 47 ? 51.934 93.837 54.581 1.00 50.54 ? 113 PRO B CD 1 ATOM 2941 N N . SER B 1 48 ? 53.040 97.564 51.961 1.00 53.30 ? 114 SER B N 1 ATOM 2942 C CA . SER B 1 48 ? 52.566 98.314 50.787 1.00 53.60 ? 114 SER B CA 1 ATOM 2943 C C . SER B 1 48 ? 53.302 97.899 49.518 1.00 56.99 ? 114 SER B C 1 ATOM 2944 O O . SER B 1 48 ? 54.421 97.400 49.612 1.00 56.52 ? 114 SER B O 1 ATOM 2945 C CB . SER B 1 48 ? 52.743 99.812 51.019 1.00 57.57 ? 114 SER B CB 1 ATOM 2946 O OG . SER B 1 48 ? 52.376 100.587 49.892 1.00 63.65 ? 114 SER B OG 1 ATOM 2947 N N . SER B 1 49 ? 52.677 98.116 48.331 1.00 53.95 ? 115 SER B N 1 ATOM 2948 C CA . SER B 1 49 ? 53.287 97.864 47.009 1.00 53.23 ? 115 SER B CA 1 ATOM 2949 C C . SER B 1 49 ? 54.404 98.897 46.784 1.00 59.13 ? 115 SER B C 1 ATOM 2950 O O . SER B 1 49 ? 55.307 98.678 45.981 1.00 59.71 ? 115 SER B O 1 ATOM 2951 C CB . SER B 1 49 ? 52.247 97.951 45.890 1.00 53.26 ? 115 SER B CB 1 ATOM 2952 O OG . SER B 1 49 ? 51.545 99.185 45.889 1.00 51.29 ? 115 SER B OG 1 ATOM 2953 N N . LYS B 1 50 ? 54.347 100.000 47.531 1.00 56.72 ? 116 LYS B N 1 ATOM 2954 C CA . LYS B 1 50 ? 55.318 101.087 47.495 1.00 57.34 ? 116 LYS B CA 1 ATOM 2955 C C . LYS B 1 50 ? 56.546 100.787 48.386 1.00 66.15 ? 116 LYS B C 1 ATOM 2956 O O . LYS B 1 50 ? 57.432 101.635 48.509 1.00 66.38 ? 116 LYS B O 1 ATOM 2957 C CB . LYS B 1 50 ? 54.636 102.425 47.825 1.00 57.95 ? 116 LYS B CB 1 ATOM 2958 C CG . LYS B 1 50 ? 53.570 102.769 46.788 1.00 67.90 ? 116 LYS B CG 1 ATOM 2959 C CD . LYS B 1 50 ? 52.630 103.891 47.207 1.00 82.43 ? 116 LYS B CD 1 ATOM 2960 C CE . LYS B 1 50 ? 51.538 104.149 46.183 1.00 101.81 ? 116 LYS B CE 1 ATOM 2961 N NZ . LYS B 1 50 ? 52.042 104.816 44.944 1.00 114.86 ? 116 LYS B NZ 1 ATOM 2962 N N . CYS B 1 51 ? 56.621 99.566 48.964 1.00 65.93 ? 117 CYS B N 1 ATOM 2963 C CA . CYS B 1 51 ? 57.756 99.146 49.778 1.00 67.77 ? 117 CYS B CA 1 ATOM 2964 C C . CYS B 1 51 ? 58.924 98.786 48.873 1.00 75.10 ? 117 CYS B C 1 ATOM 2965 O O . CYS B 1 51 ? 58.753 97.968 47.960 1.00 75.33 ? 117 CYS B O 1 ATOM 2966 C CB . CYS B 1 51 ? 57.398 97.985 50.700 1.00 68.66 ? 117 CYS B CB 1 ATOM 2967 S SG . CYS B 1 51 ? 58.800 97.354 51.668 1.00 73.21 ? 117 CYS B SG 1 ATOM 2968 N N . SER B 1 52 ? 60.125 99.358 49.156 1.00 73.07 ? 118 SER B N 1 ATOM 2969 C CA . SER B 1 52 ? 61.336 99.068 48.382 1.00 73.63 ? 118 SER B CA 1 ATOM 2970 C C . SER B 1 52 ? 61.678 97.588 48.445 1.00 78.69 ? 118 SER B C 1 ATOM 2971 O O . SER B 1 52 ? 61.723 97.015 49.535 1.00 78.63 ? 118 SER B O 1 ATOM 2972 C CB . SER B 1 52 ? 62.522 99.879 48.886 1.00 77.31 ? 118 SER B CB 1 ATOM 2973 O OG . SER B 1 52 ? 63.683 99.461 48.186 1.00 85.00 ? 118 SER B OG 1 ATOM 2974 N N . ARG B 1 53 ? 61.940 96.981 47.273 1.00 74.84 ? 119 ARG B N 1 ATOM 2975 C CA . ARG B 1 53 ? 62.299 95.566 47.144 1.00 74.03 ? 119 ARG B CA 1 ATOM 2976 C C . ARG B 1 53 ? 63.693 95.269 47.726 1.00 77.73 ? 119 ARG B C 1 ATOM 2977 O O . ARG B 1 53 ? 64.096 94.098 47.768 1.00 77.11 ? 119 ARG B O 1 ATOM 2978 C CB . ARG B 1 53 ? 62.172 95.092 45.685 1.00 73.11 ? 119 ARG B CB 1 ATOM 2979 N N . LEU B 1 54 ? 64.411 96.335 48.201 1.00 74.12 ? 120 LEU B N 1 ATOM 2980 C CA . LEU B 1 54 ? 65.722 96.248 48.859 1.00 74.12 ? 120 LEU B CA 1 ATOM 2981 C C . LEU B 1 54 ? 65.562 95.486 50.179 1.00 77.29 ? 120 LEU B C 1 ATOM 2982 O O . LEU B 1 54 ? 66.458 94.732 50.572 1.00 76.74 ? 120 LEU B O 1 ATOM 2983 C CB . LEU B 1 54 ? 66.407 97.642 49.033 1.00 74.35 ? 120 LEU B CB 1 ATOM 2984 C CG . LEU B 1 54 ? 66.063 98.557 50.240 1.00 79.67 ? 120 LEU B CG 1 ATOM 2985 C CD1 . LEU B 1 54 ? 66.936 98.233 51.459 1.00 80.08 ? 120 LEU B CD1 1 ATOM 2986 C CD2 . LEU B 1 54 ? 66.300 100.029 49.896 1.00 83.04 ? 120 LEU B CD2 1 ATOM 2987 N N . TYR B 1 55 ? 64.396 95.686 50.845 1.00 73.33 ? 121 TYR B N 1 ATOM 2988 C CA . TYR B 1 55 ? 63.989 94.987 52.057 1.00 72.90 ? 121 TYR B CA 1 ATOM 2989 C C . TYR B 1 55 ? 63.513 93.611 51.580 1.00 75.66 ? 121 TYR B C 1 ATOM 2990 O O . TYR B 1 55 ? 62.513 93.523 50.853 1.00 74.12 ? 121 TYR B O 1 ATOM 2991 C CB . TYR B 1 55 ? 62.814 95.707 52.752 1.00 74.07 ? 121 TYR B CB 1 ATOM 2992 C CG . TYR B 1 55 ? 63.075 97.128 53.197 1.00 76.22 ? 121 TYR B CG 1 ATOM 2993 C CD1 . TYR B 1 55 ? 63.768 97.394 54.375 1.00 77.99 ? 121 TYR B CD1 1 ATOM 2994 C CD2 . TYR B 1 55 ? 62.528 98.206 52.506 1.00 77.21 ? 121 TYR B CD2 1 ATOM 2995 C CE1 . TYR B 1 55 ? 63.964 98.703 54.821 1.00 78.60 ? 121 TYR B CE1 1 ATOM 2996 C CE2 . TYR B 1 55 ? 62.721 99.517 52.939 1.00 78.18 ? 121 TYR B CE2 1 ATOM 2997 C CZ . TYR B 1 55 ? 63.433 99.763 54.102 1.00 85.55 ? 121 TYR B CZ 1 ATOM 2998 O OH . TYR B 1 55 ? 63.609 101.058 54.536 1.00 86.76 ? 121 TYR B OH 1 ATOM 2999 N N . THR B 1 56 ? 64.253 92.548 51.952 1.00 72.93 ? 122 THR B N 1 ATOM 3000 C CA . THR B 1 56 ? 63.933 91.158 51.589 1.00 73.18 ? 122 THR B CA 1 ATOM 3001 C C . THR B 1 56 ? 62.557 90.724 52.148 1.00 77.86 ? 122 THR B C 1 ATOM 3002 O O . THR B 1 56 ? 61.892 89.876 51.539 1.00 77.52 ? 122 THR B O 1 ATOM 3003 C CB . THR B 1 56 ? 65.077 90.202 51.972 1.00 79.47 ? 122 THR B CB 1 ATOM 3004 O OG1 . THR B 1 56 ? 65.538 90.508 53.287 1.00 77.27 ? 122 THR B OG1 1 ATOM 3005 C CG2 . THR B 1 56 ? 66.244 90.272 50.999 1.00 79.43 ? 122 THR B CG2 1 ATOM 3006 N N . ALA B 1 57 ? 62.122 91.356 53.274 1.00 74.08 ? 123 ALA B N 1 ATOM 3007 C CA . ALA B 1 57 ? 60.840 91.122 53.936 1.00 73.79 ? 123 ALA B CA 1 ATOM 3008 C C . ALA B 1 57 ? 59.643 91.425 53.023 1.00 78.11 ? 123 ALA B C 1 ATOM 3009 O O . ALA B 1 57 ? 58.709 90.626 52.988 1.00 78.97 ? 123 ALA B O 1 ATOM 3010 C CB . ALA B 1 57 ? 60.751 91.932 55.222 1.00 74.51 ? 123 ALA B CB 1 ATOM 3011 N N . CYS B 1 58 ? 59.678 92.546 52.262 1.00 72.95 ? 124 CYS B N 1 ATOM 3012 C CA . CYS B 1 58 ? 58.588 92.934 51.362 1.00 71.65 ? 124 CYS B CA 1 ATOM 3013 C C . CYS B 1 58 ? 58.454 92.019 50.150 1.00 77.41 ? 124 CYS B C 1 ATOM 3014 O O . CYS B 1 58 ? 57.330 91.740 49.724 1.00 78.33 ? 124 CYS B O 1 ATOM 3015 C CB . CYS B 1 58 ? 58.699 94.397 50.971 1.00 70.56 ? 124 CYS B CB 1 ATOM 3016 S SG . CYS B 1 58 ? 58.221 95.523 52.304 1.00 73.64 ? 124 CYS B SG 1 ATOM 3017 N N . VAL B 1 59 ? 59.579 91.475 49.669 1.00 74.31 ? 125 VAL B N 1 ATOM 3018 C CA . VAL B 1 59 ? 59.645 90.494 48.570 1.00 74.14 ? 125 VAL B CA 1 ATOM 3019 C C . VAL B 1 59 ? 58.942 89.171 49.009 1.00 76.81 ? 125 VAL B C 1 ATOM 3020 O O . VAL B 1 59 ? 58.252 88.544 48.205 1.00 75.83 ? 125 VAL B O 1 ATOM 3021 C CB . VAL B 1 59 ? 61.126 90.262 48.148 1.00 77.79 ? 125 VAL B CB 1 ATOM 3022 C CG1 . VAL B 1 59 ? 61.257 89.160 47.096 1.00 77.55 ? 125 VAL B CG1 1 ATOM 3023 C CG2 . VAL B 1 59 ? 61.774 91.560 47.662 1.00 77.49 ? 125 VAL B CG2 1 ATOM 3024 N N . TYR B 1 60 ? 59.129 88.769 50.285 1.00 73.15 ? 126 TYR B N 1 ATOM 3025 C CA . TYR B 1 60 ? 58.562 87.553 50.885 1.00 72.38 ? 126 TYR B CA 1 ATOM 3026 C C . TYR B 1 60 ? 57.140 87.707 51.479 1.00 73.94 ? 126 TYR B C 1 ATOM 3027 O O . TYR B 1 60 ? 56.646 86.752 52.071 1.00 74.66 ? 126 TYR B O 1 ATOM 3028 C CB . TYR B 1 60 ? 59.515 86.996 51.939 1.00 73.06 ? 126 TYR B CB 1 ATOM 3029 N N . HIS B 1 61 ? 56.474 88.865 51.307 1.00 67.37 ? 127 HIS B N 1 ATOM 3030 C CA . HIS B 1 61 ? 55.138 89.098 51.845 1.00 66.18 ? 127 HIS B CA 1 ATOM 3031 C C . HIS B 1 61 ? 54.157 89.659 50.806 1.00 67.05 ? 127 HIS B C 1 ATOM 3032 O O . HIS B 1 61 ? 54.560 90.133 49.740 1.00 65.63 ? 127 HIS B O 1 ATOM 3033 C CB . HIS B 1 61 ? 55.210 89.996 53.105 1.00 67.24 ? 127 HIS B CB 1 ATOM 3034 C CG . HIS B 1 61 ? 55.701 89.274 54.322 1.00 70.69 ? 127 HIS B CG 1 ATOM 3035 N ND1 . HIS B 1 61 ? 57.018 89.363 54.743 1.00 72.50 ? 127 HIS B ND1 1 ATOM 3036 C CD2 . HIS B 1 61 ? 55.039 88.434 55.145 1.00 72.46 ? 127 HIS B CD2 1 ATOM 3037 C CE1 . HIS B 1 61 ? 57.110 88.588 55.812 1.00 72.03 ? 127 HIS B CE1 1 ATOM 3038 N NE2 . HIS B 1 61 ? 55.938 88.022 56.102 1.00 72.33 ? 127 HIS B NE2 1 ATOM 3039 N N . LYS B 1 62 ? 52.863 89.540 51.109 1.00 62.20 ? 128 LYS B N 1 ATOM 3040 C CA . LYS B 1 62 ? 51.780 90.068 50.293 1.00 60.50 ? 128 LYS B CA 1 ATOM 3041 C C . LYS B 1 62 ? 51.814 91.603 50.460 1.00 60.32 ? 128 LYS B C 1 ATOM 3042 O O . LYS B 1 62 ? 52.018 92.098 51.567 1.00 59.87 ? 128 LYS B O 1 ATOM 3043 C CB . LYS B 1 62 ? 50.429 89.469 50.756 1.00 62.18 ? 128 LYS B CB 1 ATOM 3044 C CG . LYS B 1 62 ? 49.230 89.793 49.866 1.00 63.21 ? 128 LYS B CG 1 ATOM 3045 C CD . LYS B 1 62 ? 49.164 88.931 48.642 1.00 68.56 ? 128 LYS B CD 1 ATOM 3046 C CE . LYS B 1 62 ? 47.750 88.873 48.116 1.00 85.43 ? 128 LYS B CE 1 ATOM 3047 N NZ . LYS B 1 62 ? 46.929 87.896 48.866 1.00 102.83 ? 128 LYS B NZ 1 ATOM 3048 N N . LEU B 1 63 ? 51.665 92.338 49.356 1.00 54.32 ? 129 LEU B N 1 ATOM 3049 C CA . LEU B 1 63 ? 51.699 93.802 49.378 1.00 53.08 ? 129 LEU B CA 1 ATOM 3050 C C . LEU B 1 63 ? 50.390 94.410 48.908 1.00 54.00 ? 129 LEU B C 1 ATOM 3051 O O . LEU B 1 63 ? 49.814 93.944 47.926 1.00 53.82 ? 129 LEU B O 1 ATOM 3052 C CB . LEU B 1 63 ? 52.876 94.340 48.529 1.00 53.06 ? 129 LEU B CB 1 ATOM 3053 C CG . LEU B 1 63 ? 54.253 93.692 48.719 1.00 57.17 ? 129 LEU B CG 1 ATOM 3054 C CD1 . LEU B 1 63 ? 55.232 94.164 47.658 1.00 56.98 ? 129 LEU B CD1 1 ATOM 3055 C CD2 . LEU B 1 63 ? 54.805 93.960 50.089 1.00 59.23 ? 129 LEU B CD2 1 ATOM 3056 N N . PHE B 1 64 ? 49.909 95.437 49.618 1.00 49.12 ? 130 PHE B N 1 ATOM 3057 C CA . PHE B 1 64 ? 48.686 96.141 49.248 1.00 48.59 ? 130 PHE B CA 1 ATOM 3058 C C . PHE B 1 64 ? 48.980 97.067 48.079 1.00 56.15 ? 130 PHE B C 1 ATOM 3059 O O . PHE B 1 64 ? 49.888 97.909 48.153 1.00 55.03 ? 130 PHE B O 1 ATOM 3060 C CB . PHE B 1 64 ? 48.111 96.960 50.427 1.00 49.57 ? 130 PHE B CB 1 ATOM 3061 C CG . PHE B 1 64 ? 46.836 97.713 50.093 1.00 50.10 ? 130 PHE B CG 1 ATOM 3062 C CD1 . PHE B 1 64 ? 45.639 97.031 49.870 1.00 53.09 ? 130 PHE B CD1 1 ATOM 3063 C CD2 . PHE B 1 64 ? 46.839 99.096 49.965 1.00 50.07 ? 130 PHE B CD2 1 ATOM 3064 C CE1 . PHE B 1 64 ? 44.465 97.730 49.535 1.00 53.18 ? 130 PHE B CE1 1 ATOM 3065 C CE2 . PHE B 1 64 ? 45.668 99.790 49.638 1.00 52.16 ? 130 PHE B CE2 1 ATOM 3066 C CZ . PHE B 1 64 ? 44.490 99.104 49.423 1.00 50.42 ? 130 PHE B CZ 1 ATOM 3067 N N . ASP B 1 65 ? 48.185 96.934 47.015 1.00 54.67 ? 131 ASP B N 1 ATOM 3068 C CA . ASP B 1 65 ? 48.304 97.788 45.842 1.00 53.99 ? 131 ASP B CA 1 ATOM 3069 C C . ASP B 1 65 ? 47.029 98.595 45.729 1.00 58.10 ? 131 ASP B C 1 ATOM 3070 O O . ASP B 1 65 ? 45.980 98.054 45.365 1.00 57.88 ? 131 ASP B O 1 ATOM 3071 C CB . ASP B 1 65 ? 48.579 96.960 44.570 1.00 55.70 ? 131 ASP B CB 1 ATOM 3072 C CG . ASP B 1 65 ? 49.218 97.728 43.424 1.00 60.18 ? 131 ASP B CG 1 ATOM 3073 O OD1 . ASP B 1 65 ? 49.040 98.960 43.361 1.00 60.58 ? 131 ASP B OD1 1 ATOM 3074 O OD2 . ASP B 1 65 ? 49.888 97.092 42.590 1.00 64.26 ? 131 ASP B OD2 1 ATOM 3075 N N . ALA B 1 66 ? 47.111 99.883 46.109 1.00 56.21 ? 132 ALA B N 1 ATOM 3076 C CA . ALA B 1 66 ? 45.996 100.830 46.091 1.00 56.98 ? 132 ALA B CA 1 ATOM 3077 C C . ALA B 1 66 ? 45.438 101.054 44.671 1.00 64.07 ? 132 ALA B C 1 ATOM 3078 O O . ALA B 1 66 ? 44.237 101.305 44.511 1.00 64.02 ? 132 ALA B O 1 ATOM 3079 C CB . ALA B 1 66 ? 46.438 102.146 46.709 1.00 57.60 ? 132 ALA B CB 1 ATOM 3080 N N . SER B 1 67 ? 46.316 100.925 43.650 1.00 62.64 ? 133 SER B N 1 ATOM 3081 C CA . SER B 1 67 ? 46.020 101.080 42.221 1.00 63.04 ? 133 SER B CA 1 ATOM 3082 C C . SER B 1 67 ? 45.052 100.001 41.685 1.00 68.60 ? 133 SER B C 1 ATOM 3083 O O . SER B 1 67 ? 44.516 100.151 40.583 1.00 68.83 ? 133 SER B O 1 ATOM 3084 C CB . SER B 1 67 ? 47.314 101.088 41.413 1.00 65.87 ? 133 SER B CB 1 ATOM 3085 O OG . SER B 1 67 ? 47.768 99.775 41.148 1.00 75.80 ? 133 SER B OG 1 ATOM 3086 N N . ASP B 1 68 ? 44.845 98.914 42.459 1.00 64.88 ? 134 ASP B N 1 ATOM 3087 C CA . ASP B 1 68 ? 43.938 97.826 42.108 1.00 64.12 ? 134 ASP B CA 1 ATOM 3088 C C . ASP B 1 68 ? 42.621 97.891 42.890 1.00 65.28 ? 134 ASP B C 1 ATOM 3089 O O . ASP B 1 68 ? 41.774 97.014 42.727 1.00 65.65 ? 134 ASP B O 1 ATOM 3090 C CB . ASP B 1 68 ? 44.627 96.472 42.311 1.00 66.47 ? 134 ASP B CB 1 ATOM 3091 C CG . ASP B 1 68 ? 45.794 96.224 41.387 1.00 78.90 ? 134 ASP B CG 1 ATOM 3092 O OD1 . ASP B 1 68 ? 45.799 96.791 40.272 1.00 82.40 ? 134 ASP B OD1 1 ATOM 3093 O OD2 . ASP B 1 68 ? 46.684 95.435 41.760 1.00 81.60 ? 134 ASP B OD2 1 ATOM 3094 N N . SER B 1 69 ? 42.439 98.942 43.711 1.00 59.28 ? 135 SER B N 1 ATOM 3095 C CA . SER B 1 69 ? 41.250 99.123 44.536 1.00 58.14 ? 135 SER B CA 1 ATOM 3096 C C . SER B 1 69 ? 40.442 100.370 44.161 1.00 60.91 ? 135 SER B C 1 ATOM 3097 O O . SER B 1 69 ? 40.976 101.482 44.168 1.00 59.74 ? 135 SER B O 1 ATOM 3098 C CB . SER B 1 69 ? 41.635 99.147 46.013 1.00 60.65 ? 135 SER B CB 1 ATOM 3099 O OG . SER B 1 69 ? 40.473 99.311 46.806 1.00 63.45 ? 135 SER B OG 1 ATOM 3100 N N . SER B 1 70 ? 39.146 100.174 43.856 1.00 57.83 ? 136 SER B N 1 ATOM 3101 C CA . SER B 1 70 ? 38.224 101.249 43.476 1.00 57.75 ? 136 SER B CA 1 ATOM 3102 C C . SER B 1 70 ? 37.671 102.018 44.684 1.00 62.59 ? 136 SER B C 1 ATOM 3103 O O . SER B 1 70 ? 37.193 103.152 44.535 1.00 63.18 ? 136 SER B O 1 ATOM 3104 C CB . SER B 1 70 ? 37.085 100.702 42.622 1.00 61.42 ? 136 SER B CB 1 ATOM 3105 O OG . SER B 1 70 ? 36.179 99.900 43.364 1.00 72.12 ? 136 SER B OG 1 ATOM 3106 N N . SER B 1 71 ? 37.745 101.405 45.879 1.00 58.23 ? 137 SER B N 1 ATOM 3107 C CA . SER B 1 71 ? 37.237 101.970 47.135 1.00 57.50 ? 137 SER B CA 1 ATOM 3108 C C . SER B 1 71 ? 38.299 102.709 47.961 1.00 60.15 ? 137 SER B C 1 ATOM 3109 O O . SER B 1 71 ? 37.979 103.287 49.004 1.00 58.63 ? 137 SER B O 1 ATOM 3110 C CB . SER B 1 71 ? 36.572 100.878 47.966 1.00 61.14 ? 137 SER B CB 1 ATOM 3111 O OG . SER B 1 71 ? 37.361 99.699 47.972 1.00 69.86 ? 137 SER B OG 1 ATOM 3112 N N . TYR B 1 72 ? 39.551 102.695 47.492 1.00 58.20 ? 138 TYR B N 1 ATOM 3113 C CA . TYR B 1 72 ? 40.670 103.357 48.156 1.00 59.18 ? 138 TYR B CA 1 ATOM 3114 C C . TYR B 1 72 ? 40.515 104.884 48.190 1.00 63.72 ? 138 TYR B C 1 ATOM 3115 O O . TYR B 1 72 ? 40.053 105.483 47.213 1.00 63.35 ? 138 TYR B O 1 ATOM 3116 C CB . TYR B 1 72 ? 41.991 102.922 47.497 1.00 60.97 ? 138 TYR B CB 1 ATOM 3117 C CG . TYR B 1 72 ? 43.187 103.818 47.753 1.00 64.71 ? 138 TYR B CG 1 ATOM 3118 C CD1 . TYR B 1 72 ? 43.916 103.726 48.939 1.00 66.69 ? 138 TYR B CD1 1 ATOM 3119 C CD2 . TYR B 1 72 ? 43.632 104.717 46.783 1.00 66.02 ? 138 TYR B CD2 1 ATOM 3120 C CE1 . TYR B 1 72 ? 45.034 104.527 49.167 1.00 67.53 ? 138 TYR B CE1 1 ATOM 3121 C CE2 . TYR B 1 72 ? 44.754 105.518 46.998 1.00 66.77 ? 138 TYR B CE2 1 ATOM 3122 C CZ . TYR B 1 72 ? 45.456 105.414 48.189 1.00 75.23 ? 138 TYR B CZ 1 ATOM 3123 O OH . TYR B 1 72 ? 46.576 106.184 48.400 1.00 77.26 ? 138 TYR B OH 1 ATOM 3124 N N . LYS B 1 73 ? 40.875 105.496 49.335 1.00 60.83 ? 139 LYS B N 1 ATOM 3125 C CA . LYS B 1 73 ? 40.870 106.952 49.551 1.00 60.49 ? 139 LYS B CA 1 ATOM 3126 C C . LYS B 1 73 ? 42.237 107.321 50.096 1.00 64.31 ? 139 LYS B C 1 ATOM 3127 O O . LYS B 1 73 ? 42.649 106.813 51.142 1.00 63.59 ? 139 LYS B O 1 ATOM 3128 C CB . LYS B 1 73 ? 39.738 107.420 50.500 1.00 62.84 ? 139 LYS B CB 1 ATOM 3129 N N . HIS B 1 74 ? 42.963 108.164 49.353 1.00 61.28 ? 140 HIS B N 1 ATOM 3130 C CA . HIS B 1 74 ? 44.311 108.606 49.700 1.00 60.41 ? 140 HIS B CA 1 ATOM 3131 C C . HIS B 1 74 ? 44.365 109.447 50.985 1.00 62.37 ? 140 HIS B C 1 ATOM 3132 O O . HIS B 1 74 ? 43.459 110.244 51.247 1.00 61.04 ? 140 HIS B O 1 ATOM 3133 C CB . HIS B 1 74 ? 44.919 109.395 48.510 1.00 61.15 ? 140 HIS B CB 1 ATOM 3134 C CG . HIS B 1 74 ? 46.198 110.110 48.836 1.00 64.37 ? 140 HIS B CG 1 ATOM 3135 N ND1 . HIS B 1 74 ? 47.402 109.429 48.867 1.00 66.20 ? 140 HIS B ND1 1 ATOM 3136 C CD2 . HIS B 1 74 ? 46.428 111.408 49.142 1.00 66.00 ? 140 HIS B CD2 1 ATOM 3137 C CE1 . HIS B 1 74 ? 48.318 110.316 49.222 1.00 65.51 ? 140 HIS B CE1 1 ATOM 3138 N NE2 . HIS B 1 74 ? 47.786 111.518 49.404 1.00 65.81 ? 140 HIS B NE2 1 ATOM 3139 N N . ASN B 1 75 ? 45.442 109.282 51.766 1.00 59.08 ? 141 ASN B N 1 ATOM 3140 C CA . ASN B 1 75 ? 45.703 110.115 52.935 1.00 59.23 ? 141 ASN B CA 1 ATOM 3141 C C . ASN B 1 75 ? 47.159 110.579 52.918 1.00 64.19 ? 141 ASN B C 1 ATOM 3142 O O . ASN B 1 75 ? 47.402 111.769 52.761 1.00 65.54 ? 141 ASN B O 1 ATOM 3143 C CB . ASN B 1 75 ? 45.262 109.497 54.260 1.00 58.91 ? 141 ASN B CB 1 ATOM 3144 C CG . ASN B 1 75 ? 45.378 110.482 55.395 1.00 80.02 ? 141 ASN B CG 1 ATOM 3145 O OD1 . ASN B 1 75 ? 46.429 110.609 56.019 1.00 76.41 ? 141 ASN B OD1 1 ATOM 3146 N ND2 . ASN B 1 75 ? 44.333 111.265 55.631 1.00 71.38 ? 141 ASN B ND2 1 ATOM 3147 N N . GLY B 1 76 ? 48.099 109.649 53.025 1.00 60.16 ? 142 GLY B N 1 ATOM 3148 C CA . GLY B 1 76 ? 49.525 109.934 52.924 1.00 59.56 ? 142 GLY B CA 1 ATOM 3149 C C . GLY B 1 76 ? 50.276 110.401 54.153 1.00 62.30 ? 142 GLY B C 1 ATOM 3150 O O . GLY B 1 76 ? 51.498 110.577 54.074 1.00 60.68 ? 142 GLY B O 1 ATOM 3151 N N . THR B 1 77 ? 49.573 110.618 55.295 1.00 58.92 ? 143 THR B N 1 ATOM 3152 C CA . THR B 1 77 ? 50.227 111.028 56.549 1.00 58.42 ? 143 THR B CA 1 ATOM 3153 C C . THR B 1 77 ? 51.232 109.950 56.965 1.00 63.57 ? 143 THR B C 1 ATOM 3154 O O . THR B 1 77 ? 50.882 108.772 56.970 1.00 63.42 ? 143 THR B O 1 ATOM 3155 C CB . THR B 1 77 ? 49.197 111.260 57.649 1.00 59.42 ? 143 THR B CB 1 ATOM 3156 O OG1 . THR B 1 77 ? 48.269 112.242 57.211 1.00 60.14 ? 143 THR B OG1 1 ATOM 3157 C CG2 . THR B 1 77 ? 49.826 111.707 58.950 1.00 56.79 ? 143 THR B CG2 1 ATOM 3158 N N . GLU B 1 78 ? 52.475 110.355 57.289 1.00 60.39 ? 144 GLU B N 1 ATOM 3159 C CA . GLU B 1 78 ? 53.541 109.454 57.725 1.00 60.30 ? 144 GLU B CA 1 ATOM 3160 C C . GLU B 1 78 ? 53.153 108.784 59.042 1.00 64.54 ? 144 GLU B C 1 ATOM 3161 O O . GLU B 1 78 ? 52.459 109.381 59.865 1.00 63.50 ? 144 GLU B O 1 ATOM 3162 C CB . GLU B 1 78 ? 54.872 110.204 57.873 1.00 61.53 ? 144 GLU B CB 1 ATOM 3163 N N . LEU B 1 79 ? 53.585 107.536 59.219 1.00 61.97 ? 145 LEU B N 1 ATOM 3164 C CA . LEU B 1 79 ? 53.278 106.726 60.381 1.00 62.18 ? 145 LEU B CA 1 ATOM 3165 C C . LEU B 1 79 ? 54.484 105.875 60.728 1.00 67.39 ? 145 LEU B C 1 ATOM 3166 O O . LEU B 1 79 ? 55.045 105.215 59.851 1.00 67.50 ? 145 LEU B O 1 ATOM 3167 C CB . LEU B 1 79 ? 52.062 105.829 60.042 1.00 62.28 ? 145 LEU B CB 1 ATOM 3168 C CG . LEU B 1 79 ? 51.617 104.814 61.093 1.00 67.43 ? 145 LEU B CG 1 ATOM 3169 C CD1 . LEU B 1 79 ? 50.916 105.489 62.268 1.00 67.41 ? 145 LEU B CD1 1 ATOM 3170 C CD2 . LEU B 1 79 ? 50.705 103.770 60.480 1.00 70.84 ? 145 LEU B CD2 1 ATOM 3171 N N . THR B 1 80 ? 54.892 105.899 62.002 1.00 64.29 ? 146 THR B N 1 ATOM 3172 C CA . THR B 1 80 ? 55.975 105.060 62.505 1.00 64.57 ? 146 THR B CA 1 ATOM 3173 C C . THR B 1 80 ? 55.415 104.259 63.677 1.00 69.91 ? 146 THR B C 1 ATOM 3174 O O . THR B 1 80 ? 54.782 104.834 64.566 1.00 68.88 ? 146 THR B O 1 ATOM 3175 C CB . THR B 1 80 ? 57.247 105.881 62.849 1.00 71.77 ? 146 THR B CB 1 ATOM 3176 O OG1 . THR B 1 80 ? 57.699 106.578 61.678 1.00 73.30 ? 146 THR B OG1 1 ATOM 3177 C CG2 . THR B 1 80 ? 58.391 105.005 63.391 1.00 66.60 ? 146 THR B CG2 1 ATOM 3178 N N . LEU B 1 81 ? 55.614 102.938 63.652 1.00 67.84 ? 147 LEU B N 1 ATOM 3179 C CA . LEU B 1 81 ? 55.166 102.029 64.702 1.00 67.96 ? 147 LEU B CA 1 ATOM 3180 C C . LEU B 1 81 ? 56.384 101.358 65.345 1.00 73.26 ? 147 LEU B C 1 ATOM 3181 O O . LEU B 1 81 ? 57.048 100.530 64.720 1.00 71.86 ? 147 LEU B O 1 ATOM 3182 C CB . LEU B 1 81 ? 54.132 101.012 64.168 1.00 67.82 ? 147 LEU B CB 1 ATOM 3183 C CG . LEU B 1 81 ? 52.822 101.625 63.656 1.00 72.54 ? 147 LEU B CG 1 ATOM 3184 C CD1 . LEU B 1 81 ? 52.279 100.856 62.479 1.00 72.70 ? 147 LEU B CD1 1 ATOM 3185 C CD2 . LEU B 1 81 ? 51.795 101.743 64.759 1.00 75.08 ? 147 LEU B CD2 1 ATOM 3186 N N . ARG B 1 82 ? 56.719 101.798 66.574 1.00 72.20 ? 148 ARG B N 1 ATOM 3187 C CA . ARG B 1 82 ? 57.845 101.286 67.349 1.00 72.50 ? 148 ARG B CA 1 ATOM 3188 C C . ARG B 1 82 ? 57.345 100.251 68.342 1.00 76.96 ? 148 ARG B C 1 ATOM 3189 O O . ARG B 1 82 ? 56.651 100.594 69.303 1.00 78.05 ? 148 ARG B O 1 ATOM 3190 C CB . ARG B 1 82 ? 58.572 102.429 68.076 1.00 73.19 ? 148 ARG B CB 1 ATOM 3191 N N . TYR B 1 83 ? 57.651 98.981 68.079 1.00 72.22 ? 149 TYR B N 1 ATOM 3192 C CA . TYR B 1 83 ? 57.248 97.888 68.956 1.00 71.80 ? 149 TYR B CA 1 ATOM 3193 C C . TYR B 1 83 ? 58.465 97.367 69.717 1.00 77.64 ? 149 TYR B C 1 ATOM 3194 O O . TYR B 1 83 ? 59.604 97.697 69.368 1.00 76.06 ? 149 TYR B O 1 ATOM 3195 C CB . TYR B 1 83 ? 56.640 96.723 68.143 1.00 71.56 ? 149 TYR B CB 1 ATOM 3196 C CG . TYR B 1 83 ? 55.465 97.051 67.241 1.00 70.69 ? 149 TYR B CG 1 ATOM 3197 C CD1 . TYR B 1 83 ? 54.229 97.415 67.777 1.00 72.08 ? 149 TYR B CD1 1 ATOM 3198 C CD2 . TYR B 1 83 ? 55.546 96.863 65.863 1.00 70.41 ? 149 TYR B CD2 1 ATOM 3199 C CE1 . TYR B 1 83 ? 53.124 97.655 66.960 1.00 72.07 ? 149 TYR B CE1 1 ATOM 3200 C CE2 . TYR B 1 83 ? 54.444 97.094 65.035 1.00 70.93 ? 149 TYR B CE2 1 ATOM 3201 C CZ . TYR B 1 83 ? 53.234 97.487 65.589 1.00 77.18 ? 149 TYR B CZ 1 ATOM 3202 O OH . TYR B 1 83 ? 52.139 97.707 64.782 1.00 75.48 ? 149 TYR B OH 1 ATOM 3203 N N . SER B 1 84 ? 58.212 96.484 70.706 1.00 76.98 ? 150 SER B N 1 ATOM 3204 C CA . SER B 1 84 ? 59.212 95.811 71.541 1.00 77.90 ? 150 SER B CA 1 ATOM 3205 C C . SER B 1 84 ? 60.081 94.841 70.734 1.00 82.43 ? 150 SER B C 1 ATOM 3206 O O . SER B 1 84 ? 61.214 94.566 71.135 1.00 82.76 ? 150 SER B O 1 ATOM 3207 C CB . SER B 1 84 ? 58.532 95.045 72.678 1.00 82.75 ? 150 SER B CB 1 ATOM 3208 O OG . SER B 1 84 ? 57.784 95.897 73.531 1.00 94.36 ? 150 SER B OG 1 ATOM 3209 N N . THR B 1 85 ? 59.556 94.311 69.618 1.00 78.15 ? 151 THR B N 1 ATOM 3210 C CA . THR B 1 85 ? 60.277 93.326 68.809 1.00 77.86 ? 151 THR B CA 1 ATOM 3211 C C . THR B 1 85 ? 60.988 93.930 67.592 1.00 80.67 ? 151 THR B C 1 ATOM 3212 O O . THR B 1 85 ? 61.889 93.302 67.030 1.00 80.58 ? 151 THR B O 1 ATOM 3213 C CB . THR B 1 85 ? 59.340 92.178 68.419 1.00 85.51 ? 151 THR B CB 1 ATOM 3214 O OG1 . THR B 1 85 ? 58.173 92.728 67.805 1.00 84.21 ? 151 THR B OG1 1 ATOM 3215 C CG2 . THR B 1 85 ? 58.955 91.304 69.622 1.00 83.38 ? 151 THR B CG2 1 ATOM 3216 N N . GLY B 1 86 ? 60.587 95.139 67.220 1.00 75.34 ? 152 GLY B N 1 ATOM 3217 C CA . GLY B 1 86 ? 61.114 95.850 66.063 1.00 74.24 ? 152 GLY B CA 1 ATOM 3218 C C . GLY B 1 86 ? 60.251 97.023 65.665 1.00 75.95 ? 152 GLY B C 1 ATOM 3219 O O . GLY B 1 86 ? 59.199 97.249 66.266 1.00 76.71 ? 152 GLY B O 1 ATOM 3220 N N . THR B 1 87 ? 60.701 97.785 64.651 1.00 69.54 ? 153 THR B N 1 ATOM 3221 C CA . THR B 1 87 ? 60.027 98.994 64.160 1.00 67.47 ? 153 THR B CA 1 ATOM 3222 C C . THR B 1 87 ? 59.603 98.867 62.706 1.00 66.45 ? 153 THR B C 1 ATOM 3223 O O . THR B 1 87 ? 60.250 98.195 61.904 1.00 65.65 ? 153 THR B O 1 ATOM 3224 C CB . THR B 1 87 ? 60.902 100.227 64.429 1.00 74.39 ? 153 THR B CB 1 ATOM 3225 O OG1 . THR B 1 87 ? 61.224 100.230 65.817 1.00 77.39 ? 153 THR B OG1 1 ATOM 3226 C CG2 . THR B 1 87 ? 60.228 101.555 64.040 1.00 70.31 ? 153 THR B CG2 1 ATOM 3227 N N . VAL B 1 88 ? 58.511 99.539 62.386 1.00 59.88 ? 154 VAL B N 1 ATOM 3228 C CA . VAL B 1 88 ? 57.896 99.561 61.075 1.00 58.31 ? 154 VAL B CA 1 ATOM 3229 C C . VAL B 1 88 ? 57.452 101.013 60.797 1.00 58.57 ? 154 VAL B C 1 ATOM 3230 O O . VAL B 1 88 ? 57.180 101.765 61.733 1.00 57.38 ? 154 VAL B O 1 ATOM 3231 C CB . VAL B 1 88 ? 56.765 98.480 61.067 1.00 61.89 ? 154 VAL B CB 1 ATOM 3232 C CG1 . VAL B 1 88 ? 55.366 99.069 60.987 1.00 61.49 ? 154 VAL B CG1 1 ATOM 3233 C CG2 . VAL B 1 88 ? 57.002 97.424 59.993 1.00 61.69 ? 154 VAL B CG2 1 ATOM 3234 N N . SER B 1 89 ? 57.471 101.431 59.530 1.00 53.85 ? 155 SER B N 1 ATOM 3235 C CA . SER B 1 89 ? 57.063 102.792 59.141 1.00 52.47 ? 155 SER B CA 1 ATOM 3236 C C . SER B 1 89 ? 56.528 102.849 57.726 1.00 52.82 ? 155 SER B C 1 ATOM 3237 O O . SER B 1 89 ? 56.869 102.011 56.878 1.00 52.71 ? 155 SER B O 1 ATOM 3238 C CB . SER B 1 89 ? 58.184 103.813 59.358 1.00 55.98 ? 155 SER B CB 1 ATOM 3239 O OG . SER B 1 89 ? 59.311 103.575 58.532 1.00 62.82 ? 155 SER B OG 1 ATOM 3240 N N . GLY B 1 90 ? 55.665 103.818 57.495 1.00 47.26 ? 156 GLY B N 1 ATOM 3241 C CA . GLY B 1 90 ? 55.031 104.031 56.205 1.00 46.57 ? 156 GLY B CA 1 ATOM 3242 C C . GLY B 1 90 ? 54.110 105.215 56.267 1.00 51.12 ? 156 GLY B C 1 ATOM 3243 O O . GLY B 1 90 ? 54.429 106.212 56.917 1.00 51.58 ? 156 GLY B O 1 ATOM 3244 N N . PHE B 1 91 ? 52.947 105.090 55.632 1.00 48.25 ? 157 PHE B N 1 ATOM 3245 C CA . PHE B 1 91 ? 51.955 106.167 55.558 1.00 47.66 ? 157 PHE B CA 1 ATOM 3246 C C . PHE B 1 91 ? 50.515 105.628 55.690 1.00 53.05 ? 157 PHE B C 1 ATOM 3247 O O . PHE B 1 91 ? 50.279 104.453 55.457 1.00 52.69 ? 157 PHE B O 1 ATOM 3248 C CB . PHE B 1 91 ? 52.142 106.946 54.227 1.00 47.99 ? 157 PHE B CB 1 ATOM 3249 C CG . PHE B 1 91 ? 51.931 106.099 52.990 1.00 47.47 ? 157 PHE B CG 1 ATOM 3250 C CD1 . PHE B 1 91 ? 52.952 105.288 52.496 1.00 48.93 ? 157 PHE B CD1 1 ATOM 3251 C CD2 . PHE B 1 91 ? 50.712 106.104 52.324 1.00 47.95 ? 157 PHE B CD2 1 ATOM 3252 C CE1 . PHE B 1 91 ? 52.748 104.474 51.379 1.00 49.02 ? 157 PHE B CE1 1 ATOM 3253 C CE2 . PHE B 1 91 ? 50.506 105.285 51.202 1.00 50.47 ? 157 PHE B CE2 1 ATOM 3254 C CZ . PHE B 1 91 ? 51.532 104.483 50.729 1.00 47.97 ? 157 PHE B CZ 1 ATOM 3255 N N . LEU B 1 92 ? 49.567 106.519 55.976 1.00 51.73 ? 158 LEU B N 1 ATOM 3256 C CA . LEU B 1 92 ? 48.138 106.279 56.168 1.00 52.86 ? 158 LEU B CA 1 ATOM 3257 C C . LEU B 1 92 ? 47.320 106.201 54.873 1.00 58.74 ? 158 LEU B C 1 ATOM 3258 O O . LEU B 1 92 ? 47.459 107.064 54.006 1.00 59.63 ? 158 LEU B O 1 ATOM 3259 C CB . LEU B 1 92 ? 47.594 107.428 57.034 1.00 53.23 ? 158 LEU B CB 1 ATOM 3260 C CG . LEU B 1 92 ? 47.010 107.103 58.413 1.00 58.22 ? 158 LEU B CG 1 ATOM 3261 C CD1 . LEU B 1 92 ? 47.916 106.160 59.224 1.00 58.29 ? 158 LEU B CD1 1 ATOM 3262 C CD2 . LEU B 1 92 ? 46.724 108.386 59.178 1.00 58.92 ? 158 LEU B CD2 1 ATOM 3263 N N . SER B 1 93 ? 46.428 105.188 54.774 1.00 54.49 ? 159 SER B N 1 ATOM 3264 C CA . SER B 1 93 ? 45.516 104.979 53.645 1.00 53.12 ? 159 SER B CA 1 ATOM 3265 C C . SER B 1 93 ? 44.147 104.574 54.166 1.00 57.05 ? 159 SER B C 1 ATOM 3266 O O . SER B 1 93 ? 44.045 104.035 55.270 1.00 57.65 ? 159 SER B O 1 ATOM 3267 C CB . SER B 1 93 ? 46.045 103.895 52.714 1.00 54.69 ? 159 SER B CB 1 ATOM 3268 O OG . SER B 1 93 ? 47.198 104.347 52.025 1.00 60.59 ? 159 SER B OG 1 ATOM 3269 N N . GLN B 1 94 ? 43.097 104.820 53.385 1.00 51.84 ? 160 GLN B N 1 ATOM 3270 C CA . GLN B 1 94 ? 41.750 104.408 53.766 1.00 51.18 ? 160 GLN B CA 1 ATOM 3271 C C . GLN B 1 94 ? 41.186 103.485 52.703 1.00 55.03 ? 160 GLN B C 1 ATOM 3272 O O . GLN B 1 94 ? 41.363 103.729 51.509 1.00 55.40 ? 160 GLN B O 1 ATOM 3273 C CB . GLN B 1 94 ? 40.807 105.608 53.984 1.00 52.15 ? 160 GLN B CB 1 ATOM 3274 C CG . GLN B 1 94 ? 39.433 105.208 54.500 1.00 58.81 ? 160 GLN B CG 1 ATOM 3275 C CD . GLN B 1 94 ? 38.398 106.239 54.191 1.00 72.28 ? 160 GLN B CD 1 ATOM 3276 O OE1 . GLN B 1 94 ? 37.835 106.287 53.090 1.00 73.11 ? 160 GLN B OE1 1 ATOM 3277 N NE2 . GLN B 1 94 ? 38.074 107.046 55.171 1.00 60.28 ? 160 GLN B NE2 1 ATOM 3278 N N . ASP B 1 95 ? 40.520 102.416 53.144 1.00 50.76 ? 161 ASP B N 1 ATOM 3279 C CA . ASP B 1 95 ? 39.846 101.456 52.284 1.00 50.32 ? 161 ASP B CA 1 ATOM 3280 C C . ASP B 1 95 ? 38.860 100.632 53.103 1.00 55.21 ? 161 ASP B C 1 ATOM 3281 O O . ASP B 1 95 ? 38.788 100.782 54.324 1.00 54.40 ? 161 ASP B O 1 ATOM 3282 C CB . ASP B 1 95 ? 40.845 100.551 51.535 1.00 51.26 ? 161 ASP B CB 1 ATOM 3283 C CG . ASP B 1 95 ? 40.411 100.214 50.120 1.00 54.17 ? 161 ASP B CG 1 ATOM 3284 O OD1 . ASP B 1 95 ? 39.202 99.995 49.903 1.00 52.08 ? 161 ASP B OD1 1 ATOM 3285 O OD2 . ASP B 1 95 ? 41.282 100.134 49.238 1.00 64.33 ? 161 ASP B OD2 1 ATOM 3286 N N . ILE B 1 96 ? 38.089 99.783 52.419 1.00 52.28 ? 162 ILE B N 1 ATOM 3287 C CA . ILE B 1 96 ? 37.131 98.881 53.025 1.00 52.51 ? 162 ILE B CA 1 ATOM 3288 C C . ILE B 1 96 ? 37.867 97.602 53.448 1.00 54.57 ? 162 ILE B C 1 ATOM 3289 O O . ILE B 1 96 ? 38.603 97.002 52.652 1.00 53.73 ? 162 ILE B O 1 ATOM 3290 C CB . ILE B 1 96 ? 35.943 98.619 52.064 1.00 56.36 ? 162 ILE B CB 1 ATOM 3291 C CG1 . ILE B 1 96 ? 35.045 99.861 51.971 1.00 57.12 ? 162 ILE B CG1 1 ATOM 3292 C CG2 . ILE B 1 96 ? 35.121 97.407 52.495 1.00 59.20 ? 162 ILE B CG2 1 ATOM 3293 C CD1 . ILE B 1 96 ? 34.255 99.985 50.665 1.00 71.56 ? 162 ILE B CD1 1 ATOM 3294 N N . ILE B 1 97 ? 37.674 97.205 54.717 1.00 48.92 ? 163 ILE B N 1 ATOM 3295 C CA . ILE B 1 97 ? 38.249 95.987 55.279 1.00 47.40 ? 163 ILE B CA 1 ATOM 3296 C C . ILE B 1 97 ? 37.133 94.986 55.623 1.00 51.79 ? 163 ILE B C 1 ATOM 3297 O O . ILE B 1 97 ? 36.137 95.354 56.262 1.00 51.65 ? 163 ILE B O 1 ATOM 3298 C CB . ILE B 1 97 ? 39.221 96.271 56.457 1.00 49.42 ? 163 ILE B CB 1 ATOM 3299 C CG1 . ILE B 1 97 ? 40.380 97.226 56.001 1.00 48.90 ? 163 ILE B CG1 1 ATOM 3300 C CG2 . ILE B 1 97 ? 39.764 94.941 57.065 1.00 49.12 ? 163 ILE B CG2 1 ATOM 3301 C CD1 . ILE B 1 97 ? 41.488 97.541 57.029 1.00 47.04 ? 163 ILE B CD1 1 ATOM 3302 N N . THR B 1 98 ? 37.289 93.738 55.178 1.00 47.62 ? 164 THR B N 1 ATOM 3303 C CA . THR B 1 98 ? 36.324 92.685 55.478 1.00 47.50 ? 164 THR B CA 1 ATOM 3304 C C . THR B 1 98 ? 36.972 91.749 56.506 1.00 48.39 ? 164 THR B C 1 ATOM 3305 O O . THR B 1 98 ? 38.086 91.282 56.272 1.00 47.70 ? 164 THR B O 1 ATOM 3306 C CB . THR B 1 98 ? 35.717 92.023 54.192 1.00 61.04 ? 164 THR B CB 1 ATOM 3307 O OG1 . THR B 1 98 ? 34.977 90.854 54.548 1.00 69.40 ? 164 THR B OG1 1 ATOM 3308 C CG2 . THR B 1 98 ? 36.752 91.664 53.141 1.00 58.02 ? 164 THR B CG2 1 ATOM 3309 N N . VAL B 1 99 ? 36.322 91.581 57.681 1.00 43.88 ? 165 VAL B N 1 ATOM 3310 C CA . VAL B 1 99 ? 36.756 90.721 58.806 1.00 43.83 ? 165 VAL B CA 1 ATOM 3311 C C . VAL B 1 99 ? 35.590 89.744 59.073 1.00 47.41 ? 165 VAL B C 1 ATOM 3312 O O . VAL B 1 99 ? 34.550 90.170 59.588 1.00 48.01 ? 165 VAL B O 1 ATOM 3313 C CB . VAL B 1 99 ? 37.109 91.522 60.107 1.00 47.42 ? 165 VAL B CB 1 ATOM 3314 C CG1 . VAL B 1 99 ? 37.780 90.624 61.143 1.00 47.09 ? 165 VAL B CG1 1 ATOM 3315 C CG2 . VAL B 1 99 ? 37.985 92.726 59.820 1.00 47.45 ? 165 VAL B CG2 1 ATOM 3316 N N . GLY B 1 100 ? 35.758 88.471 58.714 1.00 43.22 ? 166 GLY B N 1 ATOM 3317 C CA . GLY B 1 100 ? 34.701 87.476 58.868 1.00 43.75 ? 166 GLY B CA 1 ATOM 3318 C C . GLY B 1 100 ? 33.529 87.826 57.972 1.00 52.12 ? 166 GLY B C 1 ATOM 3319 O O . GLY B 1 100 ? 33.673 87.821 56.747 1.00 54.18 ? 166 GLY B O 1 ATOM 3320 N N . GLY B 1 101 ? 32.404 88.215 58.564 1.00 49.36 ? 167 GLY B N 1 ATOM 3321 C CA . GLY B 1 101 ? 31.233 88.616 57.780 1.00 50.22 ? 167 GLY B CA 1 ATOM 3322 C C . GLY B 1 101 ? 30.877 90.100 57.808 1.00 55.27 ? 167 GLY B C 1 ATOM 3323 O O . GLY B 1 101 ? 29.780 90.475 57.381 1.00 55.31 ? 167 GLY B O 1 ATOM 3324 N N . ILE B 1 102 ? 31.817 90.954 58.282 1.00 51.33 ? 168 ILE B N 1 ATOM 3325 C CA . ILE B 1 102 ? 31.670 92.391 58.511 1.00 50.84 ? 168 ILE B CA 1 ATOM 3326 C C . ILE B 1 102 ? 32.567 93.186 57.567 1.00 55.02 ? 168 ILE B C 1 ATOM 3327 O O . ILE B 1 102 ? 33.737 92.846 57.403 1.00 54.41 ? 168 ILE B O 1 ATOM 3328 C CB . ILE B 1 102 ? 32.034 92.704 60.013 1.00 53.84 ? 168 ILE B CB 1 ATOM 3329 C CG1 . ILE B 1 102 ? 31.112 91.944 60.986 1.00 54.10 ? 168 ILE B CG1 1 ATOM 3330 C CG2 . ILE B 1 102 ? 32.056 94.215 60.316 1.00 53.64 ? 168 ILE B CG2 1 ATOM 3331 C CD1 . ILE B 1 102 ? 31.525 92.014 62.439 1.00 61.92 ? 168 ILE B CD1 1 ATOM 3332 N N . THR B 1 103 ? 32.028 94.261 56.984 1.00 52.27 ? 169 THR B N 1 ATOM 3333 C CA . THR B 1 103 ? 32.768 95.192 56.134 1.00 51.66 ? 169 THR B CA 1 ATOM 3334 C C . THR B 1 103 ? 32.829 96.511 56.884 1.00 54.84 ? 169 THR B C 1 ATOM 3335 O O . THR B 1 103 ? 31.804 96.983 57.368 1.00 55.04 ? 169 THR B O 1 ATOM 3336 C CB . THR B 1 103 ? 32.136 95.347 54.738 1.00 61.35 ? 169 THR B CB 1 ATOM 3337 O OG1 . THR B 1 103 ? 30.787 95.788 54.851 1.00 71.42 ? 169 THR B OG1 1 ATOM 3338 C CG2 . THR B 1 103 ? 32.270 94.094 53.892 1.00 54.99 ? 169 THR B CG2 1 ATOM 3339 N N . VAL B 1 104 ? 34.023 97.093 57.008 1.00 50.71 ? 170 VAL B N 1 ATOM 3340 C CA . VAL B 1 104 ? 34.210 98.361 57.711 1.00 49.83 ? 170 VAL B CA 1 ATOM 3341 C C . VAL B 1 104 ? 35.167 99.293 56.952 1.00 52.72 ? 170 VAL B C 1 ATOM 3342 O O . VAL B 1 104 ? 36.181 98.825 56.429 1.00 52.37 ? 170 VAL B O 1 ATOM 3343 C CB . VAL B 1 104 ? 34.631 98.118 59.188 1.00 53.09 ? 170 VAL B CB 1 ATOM 3344 C CG1 . VAL B 1 104 ? 35.923 97.312 59.290 1.00 53.01 ? 170 VAL B CG1 1 ATOM 3345 C CG2 . VAL B 1 104 ? 34.726 99.417 59.987 1.00 52.49 ? 170 VAL B CG2 1 ATOM 3346 N N . THR B 1 105 ? 34.827 100.601 56.871 1.00 48.13 ? 171 THR B N 1 ATOM 3347 C CA . THR B 1 105 ? 35.680 101.610 56.242 1.00 47.28 ? 171 THR B CA 1 ATOM 3348 C C . THR B 1 105 ? 36.753 101.913 57.279 1.00 49.79 ? 171 THR B C 1 ATOM 3349 O O . THR B 1 105 ? 36.431 102.386 58.372 1.00 49.55 ? 171 THR B O 1 ATOM 3350 C CB . THR B 1 105 ? 34.849 102.818 55.769 1.00 54.09 ? 171 THR B CB 1 ATOM 3351 O OG1 . THR B 1 105 ? 34.096 102.405 54.629 1.00 56.34 ? 171 THR B OG1 1 ATOM 3352 C CG2 . THR B 1 105 ? 35.720 104.023 55.398 1.00 50.23 ? 171 THR B CG2 1 ATOM 3353 N N . GLN B 1 106 ? 38.012 101.590 56.960 1.00 45.81 ? 172 GLN B N 1 ATOM 3354 C CA . GLN B 1 106 ? 39.093 101.715 57.922 1.00 46.39 ? 172 GLN B CA 1 ATOM 3355 C C . GLN B 1 106 ? 40.310 102.496 57.441 1.00 50.03 ? 172 GLN B C 1 ATOM 3356 O O . GLN B 1 106 ? 40.730 102.343 56.300 1.00 49.73 ? 172 GLN B O 1 ATOM 3357 C CB . GLN B 1 106 ? 39.511 100.278 58.353 1.00 48.13 ? 172 GLN B CB 1 ATOM 3358 C CG . GLN B 1 106 ? 40.514 100.157 59.506 1.00 47.94 ? 172 GLN B CG 1 ATOM 3359 C CD . GLN B 1 106 ? 39.949 100.701 60.788 1.00 56.48 ? 172 GLN B CD 1 ATOM 3360 O OE1 . GLN B 1 106 ? 38.770 100.523 61.101 1.00 57.76 ? 172 GLN B OE1 1 ATOM 3361 N NE2 . GLN B 1 106 ? 40.773 101.396 61.544 1.00 43.24 ? 172 GLN B NE2 1 ATOM 3362 N N . MET B 1 107 ? 40.911 103.277 58.355 1.00 47.43 ? 173 MET B N 1 ATOM 3363 C CA . MET B 1 107 ? 42.172 103.978 58.131 1.00 47.71 ? 173 MET B CA 1 ATOM 3364 C C . MET B 1 107 ? 43.265 103.014 58.636 1.00 49.55 ? 173 MET B C 1 ATOM 3365 O O . MET B 1 107 ? 43.202 102.494 59.764 1.00 48.27 ? 173 MET B O 1 ATOM 3366 C CB . MET B 1 107 ? 42.209 105.337 58.857 1.00 50.73 ? 173 MET B CB 1 ATOM 3367 C CG . MET B 1 107 ? 43.402 106.216 58.474 1.00 56.21 ? 173 MET B CG 1 ATOM 3368 S SD . MET B 1 107 ? 43.409 106.843 56.750 1.00 63.01 ? 173 MET B SD 1 ATOM 3369 C CE . MET B 1 107 ? 41.959 107.951 56.791 1.00 59.64 ? 173 MET B CE 1 ATOM 3370 N N . PHE B 1 108 ? 44.223 102.722 57.766 1.00 45.07 ? 174 PHE B N 1 ATOM 3371 C CA . PHE B 1 108 ? 45.273 101.765 58.076 1.00 44.30 ? 174 PHE B CA 1 ATOM 3372 C C . PHE B 1 108 ? 46.615 102.265 57.557 1.00 50.38 ? 174 PHE B C 1 ATOM 3373 O O . PHE B 1 108 ? 46.662 103.183 56.736 1.00 50.05 ? 174 PHE B O 1 ATOM 3374 C CB . PHE B 1 108 ? 44.906 100.372 57.481 1.00 45.03 ? 174 PHE B CB 1 ATOM 3375 C CG . PHE B 1 108 ? 44.862 100.290 55.968 1.00 44.76 ? 174 PHE B CG 1 ATOM 3376 C CD1 . PHE B 1 108 ? 43.747 100.719 55.266 1.00 46.47 ? 174 PHE B CD1 1 ATOM 3377 C CD2 . PHE B 1 108 ? 45.942 99.786 55.250 1.00 45.61 ? 174 PHE B CD2 1 ATOM 3378 C CE1 . PHE B 1 108 ? 43.718 100.657 53.869 1.00 46.94 ? 174 PHE B CE1 1 ATOM 3379 C CE2 . PHE B 1 108 ? 45.912 99.733 53.854 1.00 47.83 ? 174 PHE B CE2 1 ATOM 3380 C CZ . PHE B 1 108 ? 44.797 100.157 53.175 1.00 45.22 ? 174 PHE B CZ 1 ATOM 3381 N N . GLY B 1 109 ? 47.683 101.642 58.025 1.00 47.12 ? 175 GLY B N 1 ATOM 3382 C CA . GLY B 1 109 ? 49.024 101.975 57.592 1.00 47.10 ? 175 GLY B CA 1 ATOM 3383 C C . GLY B 1 109 ? 49.496 101.076 56.477 1.00 52.40 ? 175 GLY B C 1 ATOM 3384 O O . GLY B 1 109 ? 49.328 99.853 56.523 1.00 50.40 ? 175 GLY B O 1 ATOM 3385 N N . GLU B 1 110 ? 50.056 101.711 55.450 1.00 51.35 ? 176 GLU B N 1 ATOM 3386 C CA . GLU B 1 110 ? 50.698 101.093 54.301 1.00 51.17 ? 176 GLU B CA 1 ATOM 3387 C C . GLU B 1 110 ? 52.177 101.215 54.649 1.00 56.33 ? 176 GLU B C 1 ATOM 3388 O O . GLU B 1 110 ? 52.686 102.329 54.788 1.00 56.44 ? 176 GLU B O 1 ATOM 3389 C CB . GLU B 1 110 ? 50.339 101.838 53.005 1.00 51.90 ? 176 GLU B CB 1 ATOM 3390 C CG . GLU B 1 110 ? 49.332 101.074 52.177 1.00 53.59 ? 176 GLU B CG 1 ATOM 3391 C CD . GLU B 1 110 ? 49.105 101.584 50.771 1.00 56.04 ? 176 GLU B CD 1 ATOM 3392 O OE1 . GLU B 1 110 ? 48.200 102.425 50.579 1.00 40.64 ? 176 GLU B OE1 1 ATOM 3393 O OE2 . GLU B 1 110 ? 49.753 101.054 49.843 1.00 46.88 ? 176 GLU B OE2 1 ATOM 3394 N N . VAL B 1 111 ? 52.820 100.072 54.905 1.00 52.88 ? 177 VAL B N 1 ATOM 3395 C CA . VAL B 1 111 ? 54.192 99.988 55.380 1.00 52.95 ? 177 VAL B CA 1 ATOM 3396 C C . VAL B 1 111 ? 55.194 99.878 54.225 1.00 59.94 ? 177 VAL B C 1 ATOM 3397 O O . VAL B 1 111 ? 55.042 99.035 53.336 1.00 59.10 ? 177 VAL B O 1 ATOM 3398 C CB . VAL B 1 111 ? 54.298 98.846 56.428 1.00 55.93 ? 177 VAL B CB 1 ATOM 3399 C CG1 . VAL B 1 111 ? 55.745 98.462 56.724 1.00 55.24 ? 177 VAL B CG1 1 ATOM 3400 C CG2 . VAL B 1 111 ? 53.566 99.234 57.712 1.00 55.57 ? 177 VAL B CG2 1 ATOM 3401 N N . THR B 1 112 ? 56.226 100.748 54.258 1.00 59.37 ? 178 THR B N 1 ATOM 3402 C CA . THR B 1 112 ? 57.286 100.828 53.233 1.00 59.83 ? 178 THR B CA 1 ATOM 3403 C C . THR B 1 112 ? 58.682 100.443 53.779 1.00 64.00 ? 178 THR B C 1 ATOM 3404 O O . THR B 1 112 ? 59.572 100.129 52.985 1.00 63.33 ? 178 THR B O 1 ATOM 3405 C CB . THR B 1 112 ? 57.277 102.205 52.551 1.00 66.54 ? 178 THR B CB 1 ATOM 3406 O OG1 . THR B 1 112 ? 57.361 103.221 53.558 1.00 67.64 ? 178 THR B OG1 1 ATOM 3407 C CG2 . THR B 1 112 ? 56.028 102.423 51.671 1.00 63.00 ? 178 THR B CG2 1 ATOM 3408 N N . GLU B 1 113 ? 58.866 100.471 55.119 1.00 60.68 ? 179 GLU B N 1 ATOM 3409 C CA . GLU B 1 113 ? 60.115 100.098 55.790 1.00 60.70 ? 179 GLU B CA 1 ATOM 3410 C C . GLU B 1 113 ? 59.853 98.878 56.685 1.00 65.43 ? 179 GLU B C 1 ATOM 3411 O O . GLU B 1 113 ? 59.130 98.964 57.686 1.00 63.57 ? 179 GLU B O 1 ATOM 3412 C CB . GLU B 1 113 ? 60.721 101.283 56.567 1.00 61.91 ? 179 GLU B CB 1 ATOM 3413 N N . MET B 1 114 ? 60.417 97.727 56.278 1.00 64.24 ? 180 MET B N 1 ATOM 3414 C CA . MET B 1 114 ? 60.228 96.442 56.943 1.00 64.55 ? 180 MET B CA 1 ATOM 3415 C C . MET B 1 114 ? 61.557 95.702 57.230 1.00 66.42 ? 180 MET B C 1 ATOM 3416 O O . MET B 1 114 ? 62.053 94.962 56.365 1.00 66.04 ? 180 MET B O 1 ATOM 3417 C CB . MET B 1 114 ? 59.273 95.578 56.105 1.00 67.44 ? 180 MET B CB 1 ATOM 3418 C CG . MET B 1 114 ? 58.437 94.662 56.931 1.00 72.03 ? 180 MET B CG 1 ATOM 3419 S SD . MET B 1 114 ? 57.005 94.072 56.012 1.00 77.14 ? 180 MET B SD 1 ATOM 3420 C CE . MET B 1 114 ? 56.242 93.072 57.256 1.00 73.94 ? 180 MET B CE 1 ATOM 3421 N N . PRO B 1 115 ? 62.134 95.862 58.450 1.00 60.60 ? 181 PRO B N 1 ATOM 3422 C CA . PRO B 1 115 ? 63.405 95.179 58.754 1.00 59.51 ? 181 PRO B CA 1 ATOM 3423 C C . PRO B 1 115 ? 63.354 93.650 58.703 1.00 61.17 ? 181 PRO B C 1 ATOM 3424 O O . PRO B 1 115 ? 62.414 93.047 59.222 1.00 61.26 ? 181 PRO B O 1 ATOM 3425 C CB . PRO B 1 115 ? 63.741 95.662 60.167 1.00 61.54 ? 181 PRO B CB 1 ATOM 3426 C CG . PRO B 1 115 ? 62.973 96.891 60.353 1.00 66.67 ? 181 PRO B CG 1 ATOM 3427 C CD . PRO B 1 115 ? 61.708 96.717 59.575 1.00 62.33 ? 181 PRO B CD 1 ATOM 3428 N N . ALA B 1 116 ? 64.387 93.030 58.091 1.00 55.36 ? 182 ALA B N 1 ATOM 3429 C CA . ALA B 1 116 ? 64.540 91.577 57.956 1.00 54.74 ? 182 ALA B CA 1 ATOM 3430 C C . ALA B 1 116 ? 64.462 90.888 59.328 1.00 57.74 ? 182 ALA B C 1 ATOM 3431 O O . ALA B 1 116 ? 63.873 89.817 59.447 1.00 56.20 ? 182 ALA B O 1 ATOM 3432 C CB . ALA B 1 116 ? 65.847 91.234 57.256 1.00 55.19 ? 182 ALA B CB 1 ATOM 3433 N N . LEU B 1 117 ? 65.031 91.526 60.363 1.00 53.83 ? 183 LEU B N 1 ATOM 3434 C CA . LEU B 1 117 ? 64.914 91.065 61.739 1.00 52.87 ? 183 LEU B CA 1 ATOM 3435 C C . LEU B 1 117 ? 63.930 92.067 62.377 1.00 58.77 ? 183 LEU B C 1 ATOM 3436 O O . LEU B 1 117 ? 64.228 93.263 62.406 1.00 57.44 ? 183 LEU B O 1 ATOM 3437 C CB . LEU B 1 117 ? 66.276 91.029 62.474 1.00 51.65 ? 183 LEU B CB 1 ATOM 3438 C CG . LEU B 1 117 ? 66.222 90.701 63.990 1.00 54.38 ? 183 LEU B CG 1 ATOM 3439 C CD1 . LEU B 1 117 ? 65.832 89.224 64.260 1.00 53.50 ? 183 LEU B CD1 1 ATOM 3440 C CD2 . LEU B 1 117 ? 67.529 91.066 64.681 1.00 53.93 ? 183 LEU B CD2 1 ATOM 3441 N N . PRO B 1 118 ? 62.685 91.651 62.703 1.00 57.55 ? 184 PRO B N 1 ATOM 3442 C CA . PRO B 1 118 ? 62.156 90.273 62.735 1.00 57.61 ? 184 PRO B CA 1 ATOM 3443 C C . PRO B 1 118 ? 61.155 89.873 61.630 1.00 61.41 ? 184 PRO B C 1 ATOM 3444 O O . PRO B 1 118 ? 60.638 88.755 61.667 1.00 61.83 ? 184 PRO B O 1 ATOM 3445 C CB . PRO B 1 118 ? 61.420 90.274 64.082 1.00 59.58 ? 184 PRO B CB 1 ATOM 3446 C CG . PRO B 1 118 ? 60.804 91.695 64.145 1.00 63.52 ? 184 PRO B CG 1 ATOM 3447 C CD . PRO B 1 118 ? 61.718 92.592 63.315 1.00 59.34 ? 184 PRO B CD 1 ATOM 3448 N N . PHE B 1 119 ? 60.856 90.761 60.671 1.00 56.69 ? 185 PHE B N 1 ATOM 3449 C CA . PHE B 1 119 ? 59.810 90.509 59.686 1.00 56.23 ? 185 PHE B CA 1 ATOM 3450 C C . PHE B 1 119 ? 60.104 89.391 58.657 1.00 58.68 ? 185 PHE B C 1 ATOM 3451 O O . PHE B 1 119 ? 59.158 88.921 58.034 1.00 58.89 ? 185 PHE B O 1 ATOM 3452 C CB . PHE B 1 119 ? 59.361 91.805 59.036 1.00 58.80 ? 185 PHE B CB 1 ATOM 3453 C CG . PHE B 1 119 ? 58.726 92.671 60.115 1.00 61.90 ? 185 PHE B CG 1 ATOM 3454 C CD1 . PHE B 1 119 ? 57.505 92.306 60.701 1.00 65.54 ? 185 PHE B CD1 1 ATOM 3455 C CD2 . PHE B 1 119 ? 59.411 93.763 60.647 1.00 65.53 ? 185 PHE B CD2 1 ATOM 3456 C CE1 . PHE B 1 119 ? 56.963 93.052 61.759 1.00 67.26 ? 185 PHE B CE1 1 ATOM 3457 C CE2 . PHE B 1 119 ? 58.868 94.513 61.703 1.00 69.06 ? 185 PHE B CE2 1 ATOM 3458 C CZ . PHE B 1 119 ? 57.644 94.159 62.246 1.00 67.39 ? 185 PHE B CZ 1 ATOM 3459 N N . MET B 1 120 ? 61.336 88.866 58.580 1.00 53.58 ? 186 MET B N 1 ATOM 3460 C CA . MET B 1 120 ? 61.624 87.686 57.762 1.00 52.97 ? 186 MET B CA 1 ATOM 3461 C C . MET B 1 120 ? 61.234 86.422 58.548 1.00 56.89 ? 186 MET B C 1 ATOM 3462 O O . MET B 1 120 ? 61.157 85.351 57.958 1.00 56.31 ? 186 MET B O 1 ATOM 3463 C CB . MET B 1 120 ? 63.105 87.609 57.338 1.00 55.19 ? 186 MET B CB 1 ATOM 3464 C CG . MET B 1 120 ? 63.429 88.427 56.101 1.00 58.47 ? 186 MET B CG 1 ATOM 3465 S SD . MET B 1 120 ? 62.479 87.940 54.622 1.00 62.21 ? 186 MET B SD 1 ATOM 3466 C CE . MET B 1 120 ? 63.384 86.447 54.109 1.00 59.21 ? 186 MET B CE 1 ATOM 3467 N N . LEU B 1 121 ? 60.991 86.555 59.873 1.00 54.33 ? 187 LEU B N 1 ATOM 3468 C CA . LEU B 1 121 ? 60.562 85.474 60.784 1.00 54.21 ? 187 LEU B CA 1 ATOM 3469 C C . LEU B 1 121 ? 59.050 85.345 60.776 1.00 53.35 ? 187 LEU B C 1 ATOM 3470 O O . LEU B 1 121 ? 58.520 84.285 61.156 1.00 54.71 ? 187 LEU B O 1 ATOM 3471 C CB . LEU B 1 121 ? 60.954 85.778 62.246 1.00 55.06 ? 187 LEU B CB 1 ATOM 3472 C CG . LEU B 1 121 ? 62.403 85.926 62.589 1.00 60.06 ? 187 LEU B CG 1 ATOM 3473 C CD1 . LEU B 1 121 ? 62.582 86.652 63.907 1.00 60.67 ? 187 LEU B CD1 1 ATOM 3474 C CD2 . LEU B 1 121 ? 62.982 84.633 62.741 1.00 62.80 ? 187 LEU B CD2 1 ATOM 3475 N N . ALA B 1 122 ? 58.381 86.467 60.464 1.00 45.20 ? 188 ALA B N 1 ATOM 3476 C CA . ALA B 1 122 ? 56.947 86.644 60.419 1.00 43.74 ? 188 ALA B CA 1 ATOM 3477 C C . ALA B 1 122 ? 56.299 85.892 59.254 1.00 46.90 ? 188 ALA B C 1 ATOM 3478 O O . ALA B 1 122 ? 56.629 86.140 58.092 1.00 46.80 ? 188 ALA B O 1 ATOM 3479 C CB . ALA B 1 122 ? 56.620 88.125 60.352 1.00 44.03 ? 188 ALA B CB 1 ATOM 3480 N N . GLU B 1 123 ? 55.368 84.969 59.580 1.00 41.34 ? 189 GLU B N 1 ATOM 3481 C CA . GLU B 1 123 ? 54.596 84.177 58.613 1.00 39.91 ? 189 GLU B CA 1 ATOM 3482 C C . GLU B 1 123 ? 53.307 84.905 58.249 1.00 42.19 ? 189 GLU B C 1 ATOM 3483 O O . GLU B 1 123 ? 52.602 84.537 57.314 1.00 43.15 ? 189 GLU B O 1 ATOM 3484 C CB . GLU B 1 123 ? 54.315 82.777 59.155 1.00 41.07 ? 189 GLU B CB 1 ATOM 3485 C CG . GLU B 1 123 ? 55.554 82.090 59.718 1.00 49.67 ? 189 GLU B CG 1 ATOM 3486 C CD . GLU B 1 123 ? 56.672 81.677 58.773 1.00 65.95 ? 189 GLU B CD 1 ATOM 3487 O OE1 . GLU B 1 123 ? 56.371 81.232 57.640 1.00 48.31 ? 189 GLU B OE1 1 ATOM 3488 O OE2 . GLU B 1 123 ? 57.852 81.744 59.194 1.00 58.64 ? 189 GLU B OE2 1 ATOM 3489 N N . PHE B 1 124 ? 53.010 85.948 58.996 1.00 37.88 ? 190 PHE B N 1 ATOM 3490 C CA . PHE B 1 124 ? 51.885 86.842 58.761 1.00 36.99 ? 190 PHE B CA 1 ATOM 3491 C C . PHE B 1 124 ? 52.426 88.002 57.935 1.00 39.99 ? 190 PHE B C 1 ATOM 3492 O O . PHE B 1 124 ? 53.637 88.214 57.895 1.00 38.23 ? 190 PHE B O 1 ATOM 3493 C CB . PHE B 1 124 ? 51.306 87.348 60.113 1.00 38.44 ? 190 PHE B CB 1 ATOM 3494 C CG . PHE B 1 124 ? 52.298 88.004 61.051 1.00 40.01 ? 190 PHE B CG 1 ATOM 3495 C CD1 . PHE B 1 124 ? 53.033 87.242 61.952 1.00 41.99 ? 190 PHE B CD1 1 ATOM 3496 C CD2 . PHE B 1 124 ? 52.473 89.384 61.052 1.00 42.63 ? 190 PHE B CD2 1 ATOM 3497 C CE1 . PHE B 1 124 ? 53.928 87.850 62.835 1.00 43.95 ? 190 PHE B CE1 1 ATOM 3498 C CE2 . PHE B 1 124 ? 53.382 89.992 61.922 1.00 45.78 ? 190 PHE B CE2 1 ATOM 3499 C CZ . PHE B 1 124 ? 54.105 89.226 62.807 1.00 44.05 ? 190 PHE B CZ 1 ATOM 3500 N N . ASP B 1 125 ? 51.526 88.784 57.334 1.00 39.29 ? 191 ASP B N 1 ATOM 3501 C CA . ASP B 1 125 ? 51.844 89.971 56.534 1.00 39.51 ? 191 ASP B CA 1 ATOM 3502 C C . ASP B 1 125 ? 51.749 91.239 57.366 1.00 44.19 ? 191 ASP B C 1 ATOM 3503 O O . ASP B 1 125 ? 52.663 92.053 57.342 1.00 44.97 ? 191 ASP B O 1 ATOM 3504 C CB . ASP B 1 125 ? 50.929 90.065 55.287 1.00 41.10 ? 191 ASP B CB 1 ATOM 3505 C CG . ASP B 1 125 ? 50.960 88.841 54.379 1.00 47.34 ? 191 ASP B CG 1 ATOM 3506 O OD1 . ASP B 1 125 ? 52.058 88.513 53.850 1.00 47.00 ? 191 ASP B OD1 1 ATOM 3507 O OD2 . ASP B 1 125 ? 49.885 88.222 54.180 1.00 51.26 ? 191 ASP B OD2 1 ATOM 3508 N N . GLY B 1 126 ? 50.672 91.380 58.127 1.00 41.36 ? 192 GLY B N 1 ATOM 3509 C CA . GLY B 1 126 ? 50.426 92.573 58.926 1.00 40.08 ? 192 GLY B CA 1 ATOM 3510 C C . GLY B 1 126 ? 49.786 92.365 60.277 1.00 42.04 ? 192 GLY B C 1 ATOM 3511 O O . GLY B 1 126 ? 49.788 91.261 60.824 1.00 41.83 ? 192 GLY B O 1 ATOM 3512 N N . VAL B 1 127 ? 49.289 93.459 60.854 1.00 36.99 ? 193 VAL B N 1 ATOM 3513 C CA . VAL B 1 127 ? 48.738 93.474 62.202 1.00 36.63 ? 193 VAL B CA 1 ATOM 3514 C C . VAL B 1 127 ? 47.388 94.207 62.252 1.00 41.93 ? 193 VAL B C 1 ATOM 3515 O O . VAL B 1 127 ? 47.229 95.249 61.629 1.00 43.59 ? 193 VAL B O 1 ATOM 3516 C CB . VAL B 1 127 ? 49.776 94.072 63.225 1.00 38.86 ? 193 VAL B CB 1 ATOM 3517 C CG1 . VAL B 1 127 ? 49.212 94.152 64.650 1.00 38.66 ? 193 VAL B CG1 1 ATOM 3518 C CG2 . VAL B 1 127 ? 51.081 93.286 63.226 1.00 37.85 ? 193 VAL B CG2 1 ATOM 3519 N N . VAL B 1 128 ? 46.431 93.644 62.999 1.00 37.13 ? 194 VAL B N 1 ATOM 3520 C CA . VAL B 1 128 ? 45.123 94.239 63.284 1.00 36.92 ? 194 VAL B CA 1 ATOM 3521 C C . VAL B 1 128 ? 45.144 94.534 64.792 1.00 39.91 ? 194 VAL B C 1 ATOM 3522 O O . VAL B 1 128 ? 44.995 93.626 65.610 1.00 39.82 ? 194 VAL B O 1 ATOM 3523 C CB . VAL B 1 128 ? 43.922 93.353 62.849 1.00 41.30 ? 194 VAL B CB 1 ATOM 3524 C CG1 . VAL B 1 128 ? 42.608 93.868 63.440 1.00 40.96 ? 194 VAL B CG1 1 ATOM 3525 C CG2 . VAL B 1 128 ? 43.821 93.296 61.325 1.00 41.86 ? 194 VAL B CG2 1 ATOM 3526 N N . GLY B 1 129 ? 45.445 95.777 65.138 1.00 36.68 ? 195 GLY B N 1 ATOM 3527 C CA . GLY B 1 129 ? 45.507 96.213 66.524 1.00 36.46 ? 195 GLY B CA 1 ATOM 3528 C C . GLY B 1 129 ? 44.127 96.188 67.161 1.00 39.60 ? 195 GLY B C 1 ATOM 3529 O O . GLY B 1 129 ? 43.195 96.849 66.674 1.00 38.52 ? 195 GLY B O 1 ATOM 3530 N N . MET B 1 130 ? 43.983 95.376 68.235 1.00 34.75 ? 196 MET B N 1 ATOM 3531 C CA . MET B 1 130 ? 42.745 95.179 68.984 1.00 33.71 ? 196 MET B CA 1 ATOM 3532 C C . MET B 1 130 ? 42.704 96.030 70.275 1.00 39.04 ? 196 MET B C 1 ATOM 3533 O O . MET B 1 130 ? 41.744 95.948 71.042 1.00 40.29 ? 196 MET B O 1 ATOM 3534 C CB . MET B 1 130 ? 42.506 93.683 69.291 1.00 35.32 ? 196 MET B CB 1 ATOM 3535 C CG . MET B 1 130 ? 42.260 92.795 68.066 1.00 38.53 ? 196 MET B CG 1 ATOM 3536 S SD . MET B 1 130 ? 40.898 93.297 66.986 1.00 43.73 ? 196 MET B SD 1 ATOM 3537 C CE . MET B 1 130 ? 39.497 92.814 67.945 1.00 40.88 ? 196 MET B CE 1 ATOM 3538 N N . GLY B 1 131 ? 43.716 96.861 70.470 1.00 35.48 ? 197 GLY B N 1 ATOM 3539 C CA . GLY B 1 131 ? 43.837 97.772 71.598 1.00 35.49 ? 197 GLY B CA 1 ATOM 3540 C C . GLY B 1 131 ? 42.940 98.990 71.480 1.00 40.63 ? 197 GLY B C 1 ATOM 3541 O O . GLY B 1 131 ? 42.174 99.130 70.517 1.00 38.90 ? 197 GLY B O 1 ATOM 3542 N N . PHE B 1 132 ? 43.034 99.887 72.474 1.00 39.43 ? 198 PHE B N 1 ATOM 3543 C CA . PHE B 1 132 ? 42.218 101.104 72.557 1.00 39.69 ? 198 PHE B CA 1 ATOM 3544 C C . PHE B 1 132 ? 42.811 102.288 71.780 1.00 48.64 ? 198 PHE B C 1 ATOM 3545 O O . PHE B 1 132 ? 44.025 102.346 71.562 1.00 47.43 ? 198 PHE B O 1 ATOM 3546 C CB . PHE B 1 132 ? 42.051 101.517 74.014 1.00 40.68 ? 198 PHE B CB 1 ATOM 3547 C CG . PHE B 1 132 ? 41.344 100.559 74.938 1.00 42.32 ? 198 PHE B CG 1 ATOM 3548 C CD1 . PHE B 1 132 ? 41.998 99.439 75.440 1.00 44.91 ? 198 PHE B CD1 1 ATOM 3549 C CD2 . PHE B 1 132 ? 40.064 100.833 75.398 1.00 45.55 ? 198 PHE B CD2 1 ATOM 3550 C CE1 . PHE B 1 132 ? 41.362 98.586 76.337 1.00 46.29 ? 198 PHE B CE1 1 ATOM 3551 C CE2 . PHE B 1 132 ? 39.426 99.971 76.291 1.00 48.42 ? 198 PHE B CE2 1 ATOM 3552 C CZ . PHE B 1 132 ? 40.072 98.846 76.737 1.00 45.96 ? 198 PHE B CZ 1 ATOM 3553 N N . ILE B 1 133 ? 41.944 103.273 71.436 1.00 48.97 ? 199 ILE B N 1 ATOM 3554 C CA . ILE B 1 133 ? 42.299 104.522 70.748 1.00 49.78 ? 199 ILE B CA 1 ATOM 3555 C C . ILE B 1 133 ? 43.405 105.297 71.501 1.00 54.18 ? 199 ILE B C 1 ATOM 3556 O O . ILE B 1 133 ? 44.245 105.903 70.850 1.00 53.81 ? 199 ILE B O 1 ATOM 3557 C CB . ILE B 1 133 ? 41.037 105.379 70.445 1.00 53.28 ? 199 ILE B CB 1 ATOM 3558 C CG1 . ILE B 1 133 ? 41.341 106.475 69.389 1.00 53.55 ? 199 ILE B CG1 1 ATOM 3559 C CG2 . ILE B 1 133 ? 40.386 105.949 71.729 1.00 54.41 ? 199 ILE B CG2 1 ATOM 3560 C CD1 . ILE B 1 133 ? 40.116 107.004 68.592 1.00 53.41 ? 199 ILE B CD1 1 ATOM 3561 N N . GLU B 1 134 ? 43.444 105.205 72.854 1.00 50.64 ? 200 GLU B N 1 ATOM 3562 C CA . GLU B 1 134 ? 44.447 105.847 73.705 1.00 49.93 ? 200 GLU B CA 1 ATOM 3563 C C . GLU B 1 134 ? 45.881 105.463 73.317 1.00 55.50 ? 200 GLU B C 1 ATOM 3564 O O . GLU B 1 134 ? 46.787 106.279 73.494 1.00 56.43 ? 200 GLU B O 1 ATOM 3565 C CB . GLU B 1 134 ? 44.198 105.536 75.202 1.00 51.08 ? 200 GLU B CB 1 ATOM 3566 C CG . GLU B 1 134 ? 42.966 106.199 75.822 1.00 55.89 ? 200 GLU B CG 1 ATOM 3567 C CD . GLU B 1 134 ? 41.632 105.482 75.706 1.00 68.40 ? 200 GLU B CD 1 ATOM 3568 O OE1 . GLU B 1 134 ? 41.454 104.660 74.777 1.00 49.13 ? 200 GLU B OE1 1 ATOM 3569 O OE2 . GLU B 1 134 ? 40.738 105.786 76.527 1.00 68.62 ? 200 GLU B OE2 1 ATOM 3570 N N . GLN B 1 135 ? 46.093 104.241 72.786 1.00 52.08 ? 201 GLN B N 1 ATOM 3571 C CA . GLN B 1 135 ? 47.427 103.756 72.377 1.00 51.71 ? 201 GLN B CA 1 ATOM 3572 C C . GLN B 1 135 ? 47.642 103.763 70.849 1.00 53.46 ? 201 GLN B C 1 ATOM 3573 O O . GLN B 1 135 ? 48.699 103.334 70.384 1.00 52.60 ? 201 GLN B O 1 ATOM 3574 C CB . GLN B 1 135 ? 47.730 102.362 72.972 1.00 53.36 ? 201 GLN B CB 1 ATOM 3575 C CG . GLN B 1 135 ? 47.500 102.233 74.480 1.00 72.15 ? 201 GLN B CG 1 ATOM 3576 C CD . GLN B 1 135 ? 48.678 102.664 75.312 1.00 94.45 ? 201 GLN B CD 1 ATOM 3577 O OE1 . GLN B 1 135 ? 49.002 103.847 75.393 1.00 88.60 ? 201 GLN B OE1 1 ATOM 3578 N NE2 . GLN B 1 135 ? 49.311 101.716 76.008 1.00 92.91 ? 201 GLN B NE2 1 ATOM 3579 N N . ALA B 1 136 ? 46.647 104.258 70.078 1.00 50.26 ? 202 ALA B N 1 ATOM 3580 C CA . ALA B 1 136 ? 46.702 104.342 68.617 1.00 50.55 ? 202 ALA B CA 1 ATOM 3581 C C . ALA B 1 136 ? 47.627 105.463 68.156 1.00 58.70 ? 202 ALA B C 1 ATOM 3582 O O . ALA B 1 136 ? 47.431 106.617 68.549 1.00 59.77 ? 202 ALA B O 1 ATOM 3583 C CB . ALA B 1 136 ? 45.304 104.532 68.043 1.00 50.89 ? 202 ALA B CB 1 ATOM 3584 N N . ILE B 1 137 ? 48.670 105.113 67.365 1.00 56.84 ? 203 ILE B N 1 ATOM 3585 C CA . ILE B 1 137 ? 49.647 106.062 66.795 1.00 56.68 ? 203 ILE B CA 1 ATOM 3586 C C . ILE B 1 137 ? 48.934 106.878 65.702 1.00 62.23 ? 203 ILE B C 1 ATOM 3587 O O . ILE B 1 137 ? 48.192 106.314 64.892 1.00 61.97 ? 203 ILE B O 1 ATOM 3588 C CB . ILE B 1 137 ? 50.948 105.352 66.295 1.00 59.44 ? 203 ILE B CB 1 ATOM 3589 C CG1 . ILE B 1 137 ? 51.601 104.457 67.391 1.00 59.79 ? 203 ILE B CG1 1 ATOM 3590 C CG2 . ILE B 1 137 ? 51.974 106.328 65.690 1.00 59.84 ? 203 ILE B CG2 1 ATOM 3591 C CD1 . ILE B 1 137 ? 52.092 105.148 68.735 1.00 63.75 ? 203 ILE B CD1 1 ATOM 3592 N N . GLY B 1 138 ? 49.113 108.199 65.747 1.00 60.01 ? 204 GLY B N 1 ATOM 3593 C CA . GLY B 1 138 ? 48.469 109.142 64.835 1.00 59.55 ? 204 GLY B CA 1 ATOM 3594 C C . GLY B 1 138 ? 47.005 109.363 65.171 1.00 63.24 ? 204 GLY B C 1 ATOM 3595 O O . GLY B 1 138 ? 46.265 109.944 64.369 1.00 62.65 ? 204 GLY B O 1 ATOM 3596 N N . ARG B 1 139 ? 46.580 108.888 66.372 1.00 59.76 ? 205 ARG B N 1 ATOM 3597 C CA . ARG B 1 139 ? 45.213 108.953 66.909 1.00 59.37 ? 205 ARG B CA 1 ATOM 3598 C C . ARG B 1 139 ? 44.169 108.440 65.889 1.00 62.87 ? 205 ARG B C 1 ATOM 3599 O O . ARG B 1 139 ? 43.099 109.039 65.719 1.00 63.80 ? 205 ARG B O 1 ATOM 3600 C CB . ARG B 1 139 ? 44.886 110.361 67.456 1.00 59.93 ? 205 ARG B CB 1 ATOM 3601 N N . VAL B 1 140 ? 44.510 107.326 65.198 1.00 57.06 ? 206 VAL B N 1 ATOM 3602 C CA . VAL B 1 140 ? 43.669 106.677 64.191 1.00 55.30 ? 206 VAL B CA 1 ATOM 3603 C C . VAL B 1 140 ? 42.646 105.790 64.922 1.00 57.95 ? 206 VAL B C 1 ATOM 3604 O O . VAL B 1 140 ? 43.032 105.020 65.805 1.00 57.44 ? 206 VAL B O 1 ATOM 3605 C CB . VAL B 1 140 ? 44.532 105.873 63.186 1.00 58.60 ? 206 VAL B CB 1 ATOM 3606 C CG1 . VAL B 1 140 ? 43.671 105.177 62.145 1.00 57.56 ? 206 VAL B CG1 1 ATOM 3607 C CG2 . VAL B 1 140 ? 45.570 106.764 62.503 1.00 58.89 ? 206 VAL B CG2 1 ATOM 3608 N N . THR B 1 141 ? 41.354 105.900 64.568 1.00 52.95 ? 207 THR B N 1 ATOM 3609 C CA . THR B 1 141 ? 40.316 105.087 65.196 1.00 51.94 ? 207 THR B CA 1 ATOM 3610 C C . THR B 1 141 ? 40.555 103.576 64.965 1.00 55.05 ? 207 THR B C 1 ATOM 3611 O O . THR B 1 141 ? 40.581 103.135 63.804 1.00 54.96 ? 207 THR B O 1 ATOM 3612 C CB . THR B 1 141 ? 38.918 105.509 64.744 1.00 55.63 ? 207 THR B CB 1 ATOM 3613 O OG1 . THR B 1 141 ? 38.808 106.921 64.817 1.00 55.46 ? 207 THR B OG1 1 ATOM 3614 C CG2 . THR B 1 141 ? 37.823 104.886 65.598 1.00 55.93 ? 207 THR B CG2 1 ATOM 3615 N N . PRO B 1 142 ? 40.710 102.771 66.055 1.00 49.28 ? 208 PRO B N 1 ATOM 3616 C CA . PRO B 1 142 ? 40.898 101.323 65.882 1.00 47.78 ? 208 PRO B CA 1 ATOM 3617 C C . PRO B 1 142 ? 39.686 100.656 65.226 1.00 49.11 ? 208 PRO B C 1 ATOM 3618 O O . PRO B 1 142 ? 38.551 101.146 65.352 1.00 49.38 ? 208 PRO B O 1 ATOM 3619 C CB . PRO B 1 142 ? 41.127 100.828 67.313 1.00 49.62 ? 208 PRO B CB 1 ATOM 3620 C CG . PRO B 1 142 ? 41.561 102.027 68.078 1.00 54.20 ? 208 PRO B CG 1 ATOM 3621 C CD . PRO B 1 142 ? 40.728 103.123 67.487 1.00 50.34 ? 208 PRO B CD 1 ATOM 3622 N N . ILE B 1 143 ? 39.938 99.558 64.493 1.00 41.95 ? 209 ILE B N 1 ATOM 3623 C CA . ILE B 1 143 ? 38.926 98.798 63.756 1.00 40.48 ? 209 ILE B CA 1 ATOM 3624 C C . ILE B 1 143 ? 37.726 98.354 64.625 1.00 46.16 ? 209 ILE B C 1 ATOM 3625 O O . ILE B 1 143 ? 36.607 98.348 64.108 1.00 47.56 ? 209 ILE B O 1 ATOM 3626 C CB . ILE B 1 143 ? 39.564 97.600 62.991 1.00 42.41 ? 209 ILE B CB 1 ATOM 3627 C CG1 . ILE B 1 143 ? 38.660 97.146 61.816 1.00 42.13 ? 209 ILE B CG1 1 ATOM 3628 C CG2 . ILE B 1 143 ? 39.959 96.434 63.935 1.00 42.49 ? 209 ILE B CG2 1 ATOM 3629 C CD1 . ILE B 1 143 ? 39.338 96.227 60.745 1.00 41.69 ? 209 ILE B CD1 1 ATOM 3630 N N . PHE B 1 144 ? 37.953 97.951 65.902 1.00 40.73 ? 210 PHE B N 1 ATOM 3631 C CA . PHE B 1 144 ? 36.859 97.496 66.760 1.00 39.82 ? 210 PHE B CA 1 ATOM 3632 C C . PHE B 1 144 ? 35.888 98.635 67.082 1.00 44.12 ? 210 PHE B C 1 ATOM 3633 O O . PHE B 1 144 ? 34.676 98.429 67.026 1.00 43.66 ? 210 PHE B O 1 ATOM 3634 C CB . PHE B 1 144 ? 37.343 96.747 68.032 1.00 40.20 ? 210 PHE B CB 1 ATOM 3635 C CG . PHE B 1 144 ? 36.240 95.901 68.641 1.00 39.72 ? 210 PHE B CG 1 ATOM 3636 C CD1 . PHE B 1 144 ? 35.769 94.764 67.987 1.00 40.19 ? 210 PHE B CD1 1 ATOM 3637 C CD2 . PHE B 1 144 ? 35.663 96.252 69.859 1.00 39.98 ? 210 PHE B CD2 1 ATOM 3638 C CE1 . PHE B 1 144 ? 34.737 93.999 68.534 1.00 40.46 ? 210 PHE B CE1 1 ATOM 3639 C CE2 . PHE B 1 144 ? 34.639 95.473 70.419 1.00 41.36 ? 210 PHE B CE2 1 ATOM 3640 C CZ . PHE B 1 144 ? 34.180 94.354 69.751 1.00 38.88 ? 210 PHE B CZ 1 ATOM 3641 N N . ASP B 1 145 ? 36.419 99.848 67.329 1.00 41.97 ? 211 ASP B N 1 ATOM 3642 C CA . ASP B 1 145 ? 35.609 101.047 67.568 1.00 42.47 ? 211 ASP B CA 1 ATOM 3643 C C . ASP B 1 145 ? 34.721 101.336 66.334 1.00 47.59 ? 211 ASP B C 1 ATOM 3644 O O . ASP B 1 145 ? 33.528 101.589 66.491 1.00 48.56 ? 211 ASP B O 1 ATOM 3645 C CB . ASP B 1 145 ? 36.493 102.249 67.929 1.00 44.03 ? 211 ASP B CB 1 ATOM 3646 C CG . ASP B 1 145 ? 37.313 102.090 69.208 1.00 54.59 ? 211 ASP B CG 1 ATOM 3647 O OD1 . ASP B 1 145 ? 38.131 101.160 69.277 1.00 55.54 ? 211 ASP B OD1 1 ATOM 3648 O OD2 . ASP B 1 145 ? 37.211 102.958 70.088 1.00 63.67 ? 211 ASP B OD2 1 ATOM 3649 N N . ASN B 1 146 ? 35.271 101.198 65.119 1.00 43.67 ? 212 ASN B N 1 ATOM 3650 C CA . ASN B 1 146 ? 34.491 101.417 63.898 1.00 43.75 ? 212 ASN B CA 1 ATOM 3651 C C . ASN B 1 146 ? 33.405 100.354 63.699 1.00 49.30 ? 212 ASN B C 1 ATOM 3652 O O . ASN B 1 146 ? 32.317 100.687 63.220 1.00 48.99 ? 212 ASN B O 1 ATOM 3653 C CB . ASN B 1 146 ? 35.395 101.565 62.658 1.00 43.22 ? 212 ASN B CB 1 ATOM 3654 C CG . ASN B 1 146 ? 36.268 102.802 62.635 1.00 52.56 ? 212 ASN B CG 1 ATOM 3655 O OD1 . ASN B 1 146 ? 35.919 103.853 63.158 1.00 49.45 ? 212 ASN B OD1 1 ATOM 3656 N ND2 . ASN B 1 146 ? 37.417 102.727 61.985 1.00 43.23 ? 212 ASN B ND2 1 ATOM 3657 N N . ILE B 1 147 ? 33.678 99.088 64.113 1.00 47.64 ? 213 ILE B N 1 ATOM 3658 C CA . ILE B 1 147 ? 32.715 97.975 64.033 1.00 47.15 ? 213 ILE B CA 1 ATOM 3659 C C . ILE B 1 147 ? 31.590 98.209 65.057 1.00 49.86 ? 213 ILE B C 1 ATOM 3660 O O . ILE B 1 147 ? 30.410 98.050 64.723 1.00 48.64 ? 213 ILE B O 1 ATOM 3661 C CB . ILE B 1 147 ? 33.400 96.584 64.149 1.00 49.98 ? 213 ILE B CB 1 ATOM 3662 C CG1 . ILE B 1 147 ? 34.309 96.318 62.918 1.00 49.80 ? 213 ILE B CG1 1 ATOM 3663 C CG2 . ILE B 1 147 ? 32.355 95.464 64.281 1.00 50.16 ? 213 ILE B CG2 1 ATOM 3664 C CD1 . ILE B 1 147 ? 35.278 95.070 63.028 1.00 50.32 ? 213 ILE B CD1 1 ATOM 3665 N N . ILE B 1 148 ? 31.959 98.650 66.276 1.00 47.09 ? 214 ILE B N 1 ATOM 3666 C CA . ILE B 1 148 ? 31.001 98.996 67.330 1.00 47.30 ? 214 ILE B CA 1 ATOM 3667 C C . ILE B 1 148 ? 30.022 100.072 66.823 1.00 51.93 ? 214 ILE B C 1 ATOM 3668 O O . ILE B 1 148 ? 28.806 99.903 66.971 1.00 52.71 ? 214 ILE B O 1 ATOM 3669 C CB . ILE B 1 148 ? 31.728 99.376 68.655 1.00 50.33 ? 214 ILE B CB 1 ATOM 3670 C CG1 . ILE B 1 148 ? 32.342 98.137 69.356 1.00 50.55 ? 214 ILE B CG1 1 ATOM 3671 C CG2 . ILE B 1 148 ? 30.845 100.176 69.616 1.00 50.90 ? 214 ILE B CG2 1 ATOM 3672 C CD1 . ILE B 1 148 ? 31.438 96.817 69.454 1.00 59.19 ? 214 ILE B CD1 1 ATOM 3673 N N . SER B 1 149 ? 30.547 101.117 66.144 1.00 48.11 ? 215 SER B N 1 ATOM 3674 C CA . SER B 1 149 ? 29.752 102.214 65.578 1.00 47.54 ? 215 SER B CA 1 ATOM 3675 C C . SER B 1 149 ? 28.649 101.759 64.635 1.00 51.19 ? 215 SER B C 1 ATOM 3676 O O . SER B 1 149 ? 27.631 102.448 64.543 1.00 52.90 ? 215 SER B O 1 ATOM 3677 C CB . SER B 1 149 ? 30.646 103.249 64.906 1.00 50.78 ? 215 SER B CB 1 ATOM 3678 O OG . SER B 1 149 ? 31.449 103.887 65.884 1.00 59.89 ? 215 SER B OG 1 ATOM 3679 N N . GLN B 1 150 ? 28.811 100.582 63.987 1.00 45.51 ? 216 GLN B N 1 ATOM 3680 C CA . GLN B 1 150 ? 27.807 100.021 63.077 1.00 44.70 ? 216 GLN B CA 1 ATOM 3681 C C . GLN B 1 150 ? 26.577 99.502 63.807 1.00 50.30 ? 216 GLN B C 1 ATOM 3682 O O . GLN B 1 150 ? 25.531 99.329 63.170 1.00 52.06 ? 216 GLN B O 1 ATOM 3683 C CB . GLN B 1 150 ? 28.379 98.886 62.214 1.00 45.73 ? 216 GLN B CB 1 ATOM 3684 C CG . GLN B 1 150 ? 29.613 99.258 61.402 1.00 62.29 ? 216 GLN B CG 1 ATOM 3685 C CD . GLN B 1 150 ? 30.036 98.152 60.473 1.00 64.89 ? 216 GLN B CD 1 ATOM 3686 O OE1 . GLN B 1 150 ? 29.636 97.003 60.603 1.00 59.02 ? 216 GLN B OE1 1 ATOM 3687 N NE2 . GLN B 1 150 ? 30.853 98.481 59.503 1.00 50.24 ? 216 GLN B NE2 1 ATOM 3688 N N . GLY B 1 151 ? 26.716 99.211 65.103 1.00 45.98 ? 217 GLY B N 1 ATOM 3689 C CA . GLY B 1 151 ? 25.639 98.682 65.936 1.00 46.15 ? 217 GLY B CA 1 ATOM 3690 C C . GLY B 1 151 ? 25.041 97.378 65.435 1.00 51.61 ? 217 GLY B C 1 ATOM 3691 O O . GLY B 1 151 ? 23.814 97.210 65.436 1.00 51.50 ? 217 GLY B O 1 ATOM 3692 N N . VAL B 1 152 ? 25.907 96.456 64.977 1.00 48.87 ? 218 VAL B N 1 ATOM 3693 C CA . VAL B 1 152 ? 25.498 95.144 64.447 1.00 48.12 ? 218 VAL B CA 1 ATOM 3694 C C . VAL B 1 152 ? 25.858 93.969 65.388 1.00 49.39 ? 218 VAL B C 1 ATOM 3695 O O . VAL B 1 152 ? 25.238 92.910 65.288 1.00 49.57 ? 218 VAL B O 1 ATOM 3696 C CB . VAL B 1 152 ? 26.002 94.883 62.992 1.00 51.19 ? 218 VAL B CB 1 ATOM 3697 C CG1 . VAL B 1 152 ? 25.481 95.951 62.026 1.00 50.64 ? 218 VAL B CG1 1 ATOM 3698 C CG2 . VAL B 1 152 ? 27.529 94.748 62.919 1.00 50.16 ? 218 VAL B CG2 1 ATOM 3699 N N . LEU B 1 153 ? 26.852 94.153 66.282 1.00 44.43 ? 219 LEU B N 1 ATOM 3700 C CA . LEU B 1 153 ? 27.337 93.110 67.203 1.00 42.96 ? 219 LEU B CA 1 ATOM 3701 C C . LEU B 1 153 ? 26.434 92.930 68.414 1.00 44.44 ? 219 LEU B C 1 ATOM 3702 O O . LEU B 1 153 ? 25.977 93.918 68.999 1.00 43.38 ? 219 LEU B O 1 ATOM 3703 C CB . LEU B 1 153 ? 28.792 93.369 67.662 1.00 42.62 ? 219 LEU B CB 1 ATOM 3704 C CG . LEU B 1 153 ? 29.914 93.420 66.607 1.00 46.58 ? 219 LEU B CG 1 ATOM 3705 C CD1 . LEU B 1 153 ? 31.226 93.727 67.268 1.00 46.71 ? 219 LEU B CD1 1 ATOM 3706 C CD2 . LEU B 1 153 ? 30.039 92.101 65.832 1.00 48.21 ? 219 LEU B CD2 1 ATOM 3707 N N . LYS B 1 154 ? 26.210 91.665 68.810 1.00 40.76 ? 220 LYS B N 1 ATOM 3708 C CA . LYS B 1 154 ? 25.366 91.299 69.949 1.00 40.21 ? 220 LYS B CA 1 ATOM 3709 C C . LYS B 1 154 ? 25.875 91.944 71.227 1.00 43.63 ? 220 LYS B C 1 ATOM 3710 O O . LYS B 1 154 ? 25.079 92.504 71.981 1.00 43.32 ? 220 LYS B O 1 ATOM 3711 C CB . LYS B 1 154 ? 25.242 89.778 70.098 1.00 42.34 ? 220 LYS B CB 1 ATOM 3712 N N . GLU B 1 155 ? 27.207 91.905 71.449 1.00 39.04 ? 221 GLU B N 1 ATOM 3713 C CA . GLU B 1 155 ? 27.861 92.494 72.620 1.00 37.23 ? 221 GLU B CA 1 ATOM 3714 C C . GLU B 1 155 ? 29.132 93.241 72.228 1.00 39.84 ? 221 GLU B C 1 ATOM 3715 O O . GLU B 1 155 ? 29.791 92.919 71.235 1.00 39.08 ? 221 GLU B O 1 ATOM 3716 C CB . GLU B 1 155 ? 28.168 91.425 73.696 1.00 38.25 ? 221 GLU B CB 1 ATOM 3717 C CG . GLU B 1 155 ? 26.968 90.679 74.290 1.00 46.31 ? 221 GLU B CG 1 ATOM 3718 C CD . GLU B 1 155 ? 25.851 91.429 75.024 1.00 66.97 ? 221 GLU B CD 1 ATOM 3719 O OE1 . GLU B 1 155 ? 26.091 92.549 75.532 1.00 51.70 ? 221 GLU B OE1 1 ATOM 3720 O OE2 . GLU B 1 155 ? 24.713 90.903 75.051 1.00 59.50 ? 221 GLU B OE2 1 ATOM 3721 N N . ASP B 1 156 ? 29.499 94.200 73.067 1.00 36.46 ? 222 ASP B N 1 ATOM 3722 C CA . ASP B 1 156 ? 30.670 95.057 72.906 1.00 36.24 ? 222 ASP B CA 1 ATOM 3723 C C . ASP B 1 156 ? 31.914 94.309 73.441 1.00 36.19 ? 222 ASP B C 1 ATOM 3724 O O . ASP B 1 156 ? 32.642 94.782 74.317 1.00 34.82 ? 222 ASP B O 1 ATOM 3725 C CB . ASP B 1 156 ? 30.374 96.378 73.648 1.00 39.28 ? 222 ASP B CB 1 ATOM 3726 C CG . ASP B 1 156 ? 31.311 97.541 73.409 1.00 59.64 ? 222 ASP B CG 1 ATOM 3727 O OD1 . ASP B 1 156 ? 32.290 97.372 72.642 1.00 61.52 ? 222 ASP B OD1 1 ATOM 3728 O OD2 . ASP B 1 156 ? 31.107 98.610 74.047 1.00 69.14 ? 222 ASP B OD2 1 ATOM 3729 N N . VAL B 1 157 ? 32.129 93.107 72.911 1.00 31.15 ? 223 VAL B N 1 ATOM 3730 C CA . VAL B 1 157 ? 33.202 92.211 73.336 1.00 30.28 ? 223 VAL B CA 1 ATOM 3731 C C . VAL B 1 157 ? 33.818 91.475 72.117 1.00 34.63 ? 223 VAL B C 1 ATOM 3732 O O . VAL B 1 157 ? 33.229 91.448 71.027 1.00 33.61 ? 223 VAL B O 1 ATOM 3733 C CB . VAL B 1 157 ? 32.693 91.176 74.406 1.00 33.58 ? 223 VAL B CB 1 ATOM 3734 C CG1 . VAL B 1 157 ? 31.875 91.832 75.540 1.00 32.82 ? 223 VAL B CG1 1 ATOM 3735 C CG2 . VAL B 1 157 ? 31.899 90.044 73.761 1.00 33.40 ? 223 VAL B CG2 1 ATOM 3736 N N . PHE B 1 158 ? 34.988 90.866 72.327 1.00 30.19 ? 224 PHE B N 1 ATOM 3737 C CA . PHE B 1 158 ? 35.656 90.009 71.363 1.00 30.75 ? 224 PHE B CA 1 ATOM 3738 C C . PHE B 1 158 ? 36.459 88.983 72.130 1.00 36.95 ? 224 PHE B C 1 ATOM 3739 O O . PHE B 1 158 ? 36.947 89.281 73.230 1.00 36.38 ? 224 PHE B O 1 ATOM 3740 C CB . PHE B 1 158 ? 36.483 90.768 70.293 1.00 31.64 ? 224 PHE B CB 1 ATOM 3741 C CG . PHE B 1 158 ? 37.598 91.615 70.851 1.00 31.44 ? 224 PHE B CG 1 ATOM 3742 C CD1 . PHE B 1 158 ? 38.857 91.069 71.084 1.00 31.59 ? 224 PHE B CD1 1 ATOM 3743 C CD2 . PHE B 1 158 ? 37.399 92.969 71.119 1.00 31.30 ? 224 PHE B CD2 1 ATOM 3744 C CE1 . PHE B 1 158 ? 39.892 91.858 71.586 1.00 32.30 ? 224 PHE B CE1 1 ATOM 3745 C CE2 . PHE B 1 158 ? 38.444 93.758 71.617 1.00 33.28 ? 224 PHE B CE2 1 ATOM 3746 C CZ . PHE B 1 158 ? 39.682 93.195 71.849 1.00 30.64 ? 224 PHE B CZ 1 ATOM 3747 N N . SER B 1 159 ? 36.530 87.754 71.584 1.00 34.64 ? 225 SER B N 1 ATOM 3748 C CA . SER B 1 159 ? 37.146 86.588 72.238 1.00 33.91 ? 225 SER B CA 1 ATOM 3749 C C . SER B 1 159 ? 38.186 85.872 71.418 1.00 35.99 ? 225 SER B C 1 ATOM 3750 O O . SER B 1 159 ? 38.090 85.837 70.194 1.00 34.27 ? 225 SER B O 1 ATOM 3751 C CB . SER B 1 159 ? 36.071 85.590 72.644 1.00 35.21 ? 225 SER B CB 1 ATOM 3752 O OG . SER B 1 159 ? 35.135 86.210 73.505 1.00 47.72 ? 225 SER B OG 1 ATOM 3753 N N . PHE B 1 160 ? 39.153 85.251 72.122 1.00 32.86 ? 226 PHE B N 1 ATOM 3754 C CA . PHE B 1 160 ? 40.275 84.518 71.550 1.00 32.53 ? 226 PHE B CA 1 ATOM 3755 C C . PHE B 1 160 ? 40.353 83.115 72.040 1.00 35.36 ? 226 PHE B C 1 ATOM 3756 O O . PHE B 1 160 ? 40.296 82.862 73.249 1.00 35.00 ? 226 PHE B O 1 ATOM 3757 C CB . PHE B 1 160 ? 41.610 85.201 71.908 1.00 34.23 ? 226 PHE B CB 1 ATOM 3758 C CG . PHE B 1 160 ? 41.965 86.342 71.005 1.00 35.68 ? 226 PHE B CG 1 ATOM 3759 C CD1 . PHE B 1 160 ? 41.318 87.572 71.122 1.00 37.63 ? 226 PHE B CD1 1 ATOM 3760 C CD2 . PHE B 1 160 ? 42.918 86.183 70.008 1.00 36.10 ? 226 PHE B CD2 1 ATOM 3761 C CE1 . PHE B 1 160 ? 41.625 88.618 70.257 1.00 38.19 ? 226 PHE B CE1 1 ATOM 3762 C CE2 . PHE B 1 160 ? 43.231 87.233 69.154 1.00 37.88 ? 226 PHE B CE2 1 ATOM 3763 C CZ . PHE B 1 160 ? 42.606 88.450 69.304 1.00 36.24 ? 226 PHE B CZ 1 ATOM 3764 N N . TYR B 1 161 ? 40.562 82.213 71.094 1.00 31.68 ? 227 TYR B N 1 ATOM 3765 C CA . TYR B 1 161 ? 40.845 80.808 71.324 1.00 31.76 ? 227 TYR B CA 1 ATOM 3766 C C . TYR B 1 161 ? 42.144 80.518 70.580 1.00 34.52 ? 227 TYR B C 1 ATOM 3767 O O . TYR B 1 161 ? 42.220 80.792 69.387 1.00 33.55 ? 227 TYR B O 1 ATOM 3768 C CB . TYR B 1 161 ? 39.690 79.892 70.835 1.00 32.66 ? 227 TYR B CB 1 ATOM 3769 C CG . TYR B 1 161 ? 40.102 78.433 70.752 1.00 34.47 ? 227 TYR B CG 1 ATOM 3770 C CD1 . TYR B 1 161 ? 40.439 77.714 71.899 1.00 36.01 ? 227 TYR B CD1 1 ATOM 3771 C CD2 . TYR B 1 161 ? 40.238 77.798 69.520 1.00 34.78 ? 227 TYR B CD2 1 ATOM 3772 C CE1 . TYR B 1 161 ? 40.882 76.397 71.820 1.00 35.09 ? 227 TYR B CE1 1 ATOM 3773 C CE2 . TYR B 1 161 ? 40.666 76.480 69.432 1.00 35.34 ? 227 TYR B CE2 1 ATOM 3774 C CZ . TYR B 1 161 ? 40.974 75.780 70.585 1.00 41.82 ? 227 TYR B CZ 1 ATOM 3775 O OH . TYR B 1 161 ? 41.397 74.484 70.480 1.00 43.62 ? 227 TYR B OH 1 ATOM 3776 N N . TYR B 1 162 ? 43.161 80.012 71.282 1.00 32.43 ? 228 TYR B N 1 ATOM 3777 C CA . TYR B 1 162 ? 44.464 79.618 70.705 1.00 32.09 ? 228 TYR B CA 1 ATOM 3778 C C . TYR B 1 162 ? 44.654 78.132 71.018 1.00 38.34 ? 228 TYR B C 1 ATOM 3779 O O . TYR B 1 162 ? 44.641 77.736 72.192 1.00 37.91 ? 228 TYR B O 1 ATOM 3780 C CB . TYR B 1 162 ? 45.634 80.431 71.334 1.00 32.09 ? 228 TYR B CB 1 ATOM 3781 C CG . TYR B 1 162 ? 45.873 81.825 70.778 1.00 32.36 ? 228 TYR B CG 1 ATOM 3782 C CD1 . TYR B 1 162 ? 45.128 82.312 69.704 1.00 33.37 ? 228 TYR B CD1 1 ATOM 3783 C CD2 . TYR B 1 162 ? 46.861 82.649 71.311 1.00 31.94 ? 228 TYR B CD2 1 ATOM 3784 C CE1 . TYR B 1 162 ? 45.348 83.589 69.192 1.00 32.27 ? 228 TYR B CE1 1 ATOM 3785 C CE2 . TYR B 1 162 ? 47.120 83.910 70.776 1.00 31.75 ? 228 TYR B CE2 1 ATOM 3786 C CZ . TYR B 1 162 ? 46.363 84.375 69.714 1.00 36.37 ? 228 TYR B CZ 1 ATOM 3787 O OH . TYR B 1 162 ? 46.598 85.631 69.204 1.00 32.39 ? 228 TYR B OH 1 ATOM 3788 N N . ASN B 1 163 ? 44.796 77.304 69.978 1.00 36.65 ? 229 ASN B N 1 ATOM 3789 C CA . ASN B 1 163 ? 44.987 75.865 70.141 1.00 37.07 ? 229 ASN B CA 1 ATOM 3790 C C . ASN B 1 163 ? 46.468 75.531 70.333 1.00 43.74 ? 229 ASN B C 1 ATOM 3791 O O . ASN B 1 163 ? 47.324 76.383 70.113 1.00 42.34 ? 229 ASN B O 1 ATOM 3792 C CB . ASN B 1 163 ? 44.430 75.129 68.910 1.00 38.42 ? 229 ASN B CB 1 ATOM 3793 C CG . ASN B 1 163 ? 44.111 73.647 69.095 1.00 46.24 ? 229 ASN B CG 1 ATOM 3794 O OD1 . ASN B 1 163 ? 44.395 73.031 70.117 1.00 37.36 ? 229 ASN B OD1 1 ATOM 3795 N ND2 . ASN B 1 163 ? 43.492 73.039 68.108 1.00 35.02 ? 229 ASN B ND2 1 ATOM 3796 N N . ARG B 1 164 ? 46.759 74.290 70.762 1.00 44.23 ? 230 ARG B N 1 ATOM 3797 C CA . ARG B 1 164 ? 48.095 73.704 70.885 1.00 45.73 ? 230 ARG B CA 1 ATOM 3798 C C . ARG B 1 164 ? 48.428 73.197 69.458 1.00 53.05 ? 230 ARG B C 1 ATOM 3799 O O . ARG B 1 164 ? 47.536 72.684 68.782 1.00 52.18 ? 230 ARG B O 1 ATOM 3800 C CB . ARG B 1 164 ? 48.079 72.516 71.881 1.00 46.27 ? 230 ARG B CB 1 ATOM 3801 C CG . ARG B 1 164 ? 48.051 72.918 73.358 1.00 57.61 ? 230 ARG B CG 1 ATOM 3802 C CD . ARG B 1 164 ? 46.718 72.638 74.040 1.00 64.41 ? 230 ARG B CD 1 ATOM 3803 N NE . ARG B 1 164 ? 46.636 73.267 75.361 1.00 70.37 ? 230 ARG B NE 1 ATOM 3804 C CZ . ARG B 1 164 ? 45.537 73.329 76.116 1.00 84.48 ? 230 ARG B CZ 1 ATOM 3805 N NH1 . ARG B 1 164 ? 44.397 72.795 75.692 1.00 79.33 ? 230 ARG B NH1 1 ATOM 3806 N NH2 . ARG B 1 164 ? 45.571 73.928 77.297 1.00 61.68 ? 230 ARG B NH2 1 ATOM 3807 N N . ASP B 1 165 ? 49.659 73.384 68.966 1.00 52.62 ? 231 ASP B N 1 ATOM 3808 C CA . ASP B 1 165 ? 50.023 72.928 67.617 1.00 53.32 ? 231 ASP B CA 1 ATOM 3809 C C . ASP B 1 165 ? 50.153 71.410 67.592 1.00 59.82 ? 231 ASP B C 1 ATOM 3810 O O . ASP B 1 165 ? 50.705 70.823 68.539 1.00 58.85 ? 231 ASP B O 1 ATOM 3811 C CB . ASP B 1 165 ? 51.333 73.585 67.145 1.00 55.37 ? 231 ASP B CB 1 ATOM 3812 C CG . ASP B 1 165 ? 51.790 73.260 65.732 1.00 65.49 ? 231 ASP B CG 1 ATOM 3813 O OD1 . ASP B 1 165 ? 50.931 73.217 64.818 1.00 64.19 ? 231 ASP B OD1 1 ATOM 3814 O OD2 . ASP B 1 165 ? 53.016 73.129 65.526 1.00 75.74 ? 231 ASP B OD2 1 ATOM 3815 N N . SER B 1 166 ? 49.620 70.787 66.506 1.00 57.74 ? 232 SER B N 1 ATOM 3816 C CA . SER B 1 166 ? 49.637 69.337 66.248 1.00 98.90 ? 232 SER B CA 1 ATOM 3817 C C . SER B 1 166 ? 49.514 69.038 64.750 1.00 116.83 ? 232 SER B C 1 ATOM 3818 O O . SER B 1 166 ? 50.433 69.314 63.981 1.00 72.12 ? 232 SER B O 1 ATOM 3819 C CB . SER B 1 166 ? 48.515 68.635 67.007 1.00 102.69 ? 232 SER B CB 1 ATOM 3820 O OG . SER B 1 166 ? 48.879 68.397 68.357 1.00 111.77 ? 232 SER B OG 1 ATOM 3821 N N . SER B 1 169 ? 48.087 66.269 62.728 1.00 77.76 ? 235 SER B N 1 ATOM 3822 C CA . SER B 1 169 ? 46.671 66.558 62.503 1.00 77.23 ? 235 SER B CA 1 ATOM 3823 C C . SER B 1 169 ? 46.431 67.933 61.839 1.00 79.18 ? 235 SER B C 1 ATOM 3824 O O . SER B 1 169 ? 47.280 68.833 61.941 1.00 78.82 ? 235 SER B O 1 ATOM 3825 C CB . SER B 1 169 ? 45.883 66.432 63.806 1.00 81.61 ? 235 SER B CB 1 ATOM 3826 O OG . SER B 1 169 ? 44.481 66.557 63.612 1.00 90.99 ? 235 SER B OG 1 ATOM 3827 N N . GLN B 1 170 ? 45.263 68.073 61.149 1.00 74.14 ? 236 GLN B N 1 ATOM 3828 C CA . GLN B 1 170 ? 44.810 69.277 60.420 1.00 72.76 ? 236 GLN B CA 1 ATOM 3829 C C . GLN B 1 170 ? 43.851 70.147 61.251 1.00 71.36 ? 236 GLN B C 1 ATOM 3830 O O . GLN B 1 170 ? 42.975 70.842 60.702 1.00 70.18 ? 236 GLN B O 1 ATOM 3831 C CB . GLN B 1 170 ? 44.174 68.884 59.075 1.00 74.52 ? 236 GLN B CB 1 ATOM 3832 C CG . GLN B 1 170 ? 44.813 69.551 57.857 1.00 92.65 ? 236 GLN B CG 1 ATOM 3833 C CD . GLN B 1 170 ? 46.304 69.342 57.767 1.00 110.57 ? 236 GLN B CD 1 ATOM 3834 O OE1 . GLN B 1 170 ? 47.074 70.305 57.750 1.00 105.98 ? 236 GLN B OE1 1 ATOM 3835 N NE2 . GLN B 1 170 ? 46.748 68.086 57.744 1.00 102.56 ? 236 GLN B NE2 1 ATOM 3836 N N . SER B 1 171 ? 44.058 70.114 62.590 1.00 63.57 ? 237 SER B N 1 ATOM 3837 C CA . SER B 1 171 ? 43.296 70.847 63.597 1.00 60.83 ? 237 SER B CA 1 ATOM 3838 C C . SER B 1 171 ? 43.271 72.364 63.374 1.00 58.06 ? 237 SER B C 1 ATOM 3839 O O . SER B 1 171 ? 44.159 72.942 62.734 1.00 57.19 ? 237 SER B O 1 ATOM 3840 C CB . SER B 1 171 ? 43.800 70.517 65.002 1.00 63.65 ? 237 SER B CB 1 ATOM 3841 O OG . SER B 1 171 ? 45.160 70.885 65.174 1.00 72.04 ? 237 SER B OG 1 ATOM 3842 N N . LEU B 1 172 ? 42.209 72.984 63.888 1.00 49.17 ? 238 LEU B N 1 ATOM 3843 C CA . LEU B 1 172 ? 41.968 74.413 63.892 1.00 46.51 ? 238 LEU B CA 1 ATOM 3844 C C . LEU B 1 172 ? 43.090 75.064 64.743 1.00 45.64 ? 238 LEU B C 1 ATOM 3845 O O . LEU B 1 172 ? 43.415 74.581 65.828 1.00 45.31 ? 238 LEU B O 1 ATOM 3846 C CB . LEU B 1 172 ? 40.568 74.605 64.514 1.00 46.73 ? 238 LEU B CB 1 ATOM 3847 C CG . LEU B 1 172 ? 40.135 75.960 65.023 1.00 51.42 ? 238 LEU B CG 1 ATOM 3848 C CD1 . LEU B 1 172 ? 39.632 76.804 63.907 1.00 51.79 ? 238 LEU B CD1 1 ATOM 3849 C CD2 . LEU B 1 172 ? 39.045 75.796 66.040 1.00 52.89 ? 238 LEU B CD2 1 ATOM 3850 N N . GLY B 1 173 ? 43.732 76.079 64.197 1.00 38.32 ? 239 GLY B N 1 ATOM 3851 C CA . GLY B 1 173 ? 44.824 76.759 64.881 1.00 36.64 ? 239 GLY B CA 1 ATOM 3852 C C . GLY B 1 173 ? 44.363 77.690 65.990 1.00 38.40 ? 239 GLY B C 1 ATOM 3853 O O . GLY B 1 173 ? 45.062 77.895 66.984 1.00 38.35 ? 239 GLY B O 1 ATOM 3854 N N . GLY B 1 174 ? 43.184 78.255 65.805 1.00 32.17 ? 240 GLY B N 1 ATOM 3855 C CA . GLY B 1 174 ? 42.584 79.183 66.744 1.00 30.68 ? 240 GLY B CA 1 ATOM 3856 C C . GLY B 1 174 ? 41.369 79.854 66.145 1.00 33.40 ? 240 GLY B C 1 ATOM 3857 O O . GLY B 1 174 ? 40.995 79.576 65.004 1.00 31.15 ? 240 GLY B O 1 ATOM 3858 N N . GLN B 1 175 ? 40.742 80.739 66.925 1.00 30.44 ? 241 GLN B N 1 ATOM 3859 C CA . GLN B 1 175 ? 39.541 81.438 66.504 1.00 29.45 ? 241 GLN B CA 1 ATOM 3860 C C . GLN B 1 175 ? 39.317 82.705 67.325 1.00 35.76 ? 241 GLN B C 1 ATOM 3861 O O . GLN B 1 175 ? 39.439 82.698 68.549 1.00 35.37 ? 241 GLN B O 1 ATOM 3862 C CB . GLN B 1 175 ? 38.331 80.498 66.632 1.00 30.06 ? 241 GLN B CB 1 ATOM 3863 C CG . GLN B 1 175 ? 37.018 81.032 66.024 1.00 34.52 ? 241 GLN B CG 1 ATOM 3864 C CD . GLN B 1 175 ? 35.824 80.428 66.719 1.00 49.78 ? 241 GLN B CD 1 ATOM 3865 O OE1 . GLN B 1 175 ? 35.746 80.375 67.957 1.00 42.79 ? 241 GLN B OE1 1 ATOM 3866 N NE2 . GLN B 1 175 ? 34.882 79.932 65.943 1.00 41.17 ? 241 GLN B NE2 1 ATOM 3867 N N . ILE B 1 176 ? 38.960 83.781 66.636 1.00 34.74 ? 242 ILE B N 1 ATOM 3868 C CA . ILE B 1 176 ? 38.575 85.051 67.226 1.00 35.20 ? 242 ILE B CA 1 ATOM 3869 C C . ILE B 1 176 ? 37.093 85.239 66.931 1.00 39.06 ? 242 ILE B C 1 ATOM 3870 O O . ILE B 1 176 ? 36.632 84.970 65.815 1.00 39.59 ? 242 ILE B O 1 ATOM 3871 C CB . ILE B 1 176 ? 39.463 86.285 66.859 1.00 39.21 ? 242 ILE B CB 1 ATOM 3872 C CG1 . ILE B 1 176 ? 38.838 87.621 67.364 1.00 39.29 ? 242 ILE B CG1 1 ATOM 3873 C CG2 . ILE B 1 176 ? 39.801 86.354 65.375 1.00 42.68 ? 242 ILE B CG2 1 ATOM 3874 C CD1 . ILE B 1 176 ? 39.657 88.917 67.149 1.00 41.65 ? 242 ILE B CD1 1 ATOM 3875 N N . VAL B 1 177 ? 36.332 85.592 67.966 1.00 33.36 ? 243 VAL B N 1 ATOM 3876 C CA . VAL B 1 177 ? 34.904 85.875 67.828 1.00 31.25 ? 243 VAL B CA 1 ATOM 3877 C C . VAL B 1 177 ? 34.697 87.372 68.137 1.00 35.40 ? 243 VAL B C 1 ATOM 3878 O O . VAL B 1 177 ? 35.070 87.826 69.208 1.00 34.46 ? 243 VAL B O 1 ATOM 3879 C CB . VAL B 1 177 ? 34.004 84.965 68.726 1.00 32.31 ? 243 VAL B CB 1 ATOM 3880 C CG1 . VAL B 1 177 ? 32.526 85.286 68.515 1.00 31.45 ? 243 VAL B CG1 1 ATOM 3881 C CG2 . VAL B 1 177 ? 34.267 83.490 68.469 1.00 31.17 ? 243 VAL B CG2 1 ATOM 3882 N N . LEU B 1 178 ? 34.149 88.129 67.185 1.00 34.21 ? 244 LEU B N 1 ATOM 3883 C CA . LEU B 1 178 ? 33.802 89.535 67.377 1.00 35.50 ? 244 LEU B CA 1 ATOM 3884 C C . LEU B 1 178 ? 32.302 89.588 67.717 1.00 37.23 ? 244 LEU B C 1 ATOM 3885 O O . LEU B 1 178 ? 31.490 89.018 66.990 1.00 35.92 ? 244 LEU B O 1 ATOM 3886 C CB . LEU B 1 178 ? 34.068 90.373 66.106 1.00 36.45 ? 244 LEU B CB 1 ATOM 3887 C CG . LEU B 1 178 ? 35.465 90.352 65.481 1.00 41.25 ? 244 LEU B CG 1 ATOM 3888 C CD1 . LEU B 1 178 ? 35.433 91.077 64.146 1.00 42.18 ? 244 LEU B CD1 1 ATOM 3889 C CD2 . LEU B 1 178 ? 36.491 90.994 66.379 1.00 41.42 ? 244 LEU B CD2 1 ATOM 3890 N N . GLY B 1 179 ? 31.964 90.215 68.838 1.00 33.47 ? 245 GLY B N 1 ATOM 3891 C CA . GLY B 1 179 ? 30.578 90.347 69.292 1.00 33.48 ? 245 GLY B CA 1 ATOM 3892 C C . GLY B 1 179 ? 30.128 89.327 70.321 1.00 36.95 ? 245 GLY B C 1 ATOM 3893 O O . GLY B 1 179 ? 28.976 89.360 70.743 1.00 36.07 ? 245 GLY B O 1 ATOM 3894 N N . GLY B 1 180 ? 31.024 88.433 70.735 1.00 34.21 ? 246 GLY B N 1 ATOM 3895 C CA . GLY B 1 180 ? 30.694 87.393 71.708 1.00 33.97 ? 246 GLY B CA 1 ATOM 3896 C C . GLY B 1 180 ? 31.808 86.403 71.955 1.00 36.58 ? 246 GLY B C 1 ATOM 3897 O O . GLY B 1 180 ? 32.980 86.716 71.737 1.00 35.77 ? 246 GLY B O 1 ATOM 3898 N N . SER B 1 181 ? 31.430 85.194 72.391 1.00 33.38 ? 247 SER B N 1 ATOM 3899 C CA . SER B 1 181 ? 32.329 84.081 72.712 1.00 32.72 ? 247 SER B CA 1 ATOM 3900 C C . SER B 1 181 ? 31.793 82.787 72.118 1.00 36.75 ? 247 SER B C 1 ATOM 3901 O O . SER B 1 181 ? 30.595 82.679 71.889 1.00 36.06 ? 247 SER B O 1 ATOM 3902 C CB . SER B 1 181 ? 32.485 83.944 74.220 1.00 34.59 ? 247 SER B CB 1 ATOM 3903 O OG . SER B 1 181 ? 31.355 83.310 74.801 1.00 50.20 ? 247 SER B OG 1 ATOM 3904 N N . ASP B 1 182 ? 32.673 81.805 71.868 1.00 34.46 ? 248 ASP B N 1 ATOM 3905 C CA . ASP B 1 182 ? 32.277 80.504 71.321 1.00 34.54 ? 248 ASP B CA 1 ATOM 3906 C C . ASP B 1 182 ? 32.323 79.432 72.415 1.00 39.00 ? 248 ASP B C 1 ATOM 3907 O O . ASP B 1 182 ? 33.419 78.972 72.757 1.00 37.82 ? 248 ASP B O 1 ATOM 3908 C CB . ASP B 1 182 ? 33.133 80.103 70.106 1.00 36.11 ? 248 ASP B CB 1 ATOM 3909 C CG . ASP B 1 182 ? 32.652 78.843 69.387 1.00 42.18 ? 248 ASP B CG 1 ATOM 3910 O OD1 . ASP B 1 182 ? 31.741 78.163 69.910 1.00 42.19 ? 248 ASP B OD1 1 ATOM 3911 O OD2 . ASP B 1 182 ? 33.182 78.543 68.304 1.00 47.53 ? 248 ASP B OD2 1 ATOM 3912 N N . PRO B 1 183 ? 31.142 78.985 72.926 1.00 36.38 ? 249 PRO B N 1 ATOM 3913 C CA . PRO B 1 183 ? 31.133 77.983 74.023 1.00 36.21 ? 249 PRO B CA 1 ATOM 3914 C C . PRO B 1 183 ? 31.755 76.629 73.676 1.00 38.52 ? 249 PRO B C 1 ATOM 3915 O O . PRO B 1 183 ? 32.070 75.891 74.583 1.00 38.03 ? 249 PRO B O 1 ATOM 3916 C CB . PRO B 1 183 ? 29.645 77.872 74.422 1.00 38.12 ? 249 PRO B CB 1 ATOM 3917 C CG . PRO B 1 183 ? 28.950 78.981 73.727 1.00 41.99 ? 249 PRO B CG 1 ATOM 3918 C CD . PRO B 1 183 ? 29.772 79.392 72.554 1.00 37.13 ? 249 PRO B CD 1 ATOM 3919 N N . GLN B 1 184 ? 32.003 76.334 72.382 1.00 36.09 ? 250 GLN B N 1 ATOM 3920 C CA . GLN B 1 184 ? 32.655 75.093 71.932 1.00 35.79 ? 250 GLN B CA 1 ATOM 3921 C C . GLN B 1 184 ? 34.122 75.027 72.370 1.00 39.01 ? 250 GLN B C 1 ATOM 3922 O O . GLN B 1 184 ? 34.683 73.926 72.499 1.00 35.95 ? 250 GLN B O 1 ATOM 3923 C CB . GLN B 1 184 ? 32.606 74.988 70.398 1.00 37.07 ? 250 GLN B CB 1 ATOM 3924 C CG . GLN B 1 184 ? 31.215 74.703 69.811 1.00 65.04 ? 250 GLN B CG 1 ATOM 3925 C CD . GLN B 1 184 ? 30.523 73.507 70.434 1.00 99.06 ? 250 GLN B CD 1 ATOM 3926 O OE1 . GLN B 1 184 ? 29.614 73.648 71.273 1.00 98.53 ? 250 GLN B OE1 1 ATOM 3927 N NE2 . GLN B 1 184 ? 30.951 72.305 70.055 1.00 92.93 ? 250 GLN B NE2 1 ATOM 3928 N N . HIS B 1 185 ? 34.754 76.218 72.571 1.00 36.13 ? 251 HIS B N 1 ATOM 3929 C CA . HIS B 1 185 ? 36.182 76.294 72.878 1.00 35.96 ? 251 HIS B CA 1 ATOM 3930 C C . HIS B 1 185 ? 36.507 76.609 74.339 1.00 36.88 ? 251 HIS B C 1 ATOM 3931 O O . HIS B 1 185 ? 37.671 76.721 74.694 1.00 35.68 ? 251 HIS B O 1 ATOM 3932 C CB . HIS B 1 185 ? 36.865 77.252 71.901 1.00 36.49 ? 251 HIS B CB 1 ATOM 3933 C CG . HIS B 1 185 ? 36.765 76.726 70.503 1.00 39.40 ? 251 HIS B CG 1 ATOM 3934 N ND1 . HIS B 1 185 ? 37.262 75.470 70.170 1.00 41.27 ? 251 HIS B ND1 1 ATOM 3935 C CD2 . HIS B 1 185 ? 36.148 77.251 69.424 1.00 41.03 ? 251 HIS B CD2 1 ATOM 3936 C CE1 . HIS B 1 185 ? 36.965 75.290 68.897 1.00 40.58 ? 251 HIS B CE1 1 ATOM 3937 N NE2 . HIS B 1 185 ? 36.288 76.326 68.404 1.00 41.22 ? 251 HIS B NE2 1 ATOM 3938 N N . TYR B 1 186 ? 35.496 76.626 75.190 1.00 33.05 ? 252 TYR B N 1 ATOM 3939 C CA . TYR B 1 186 ? 35.698 76.802 76.613 1.00 33.69 ? 252 TYR B CA 1 ATOM 3940 C C . TYR B 1 186 ? 34.715 75.972 77.446 1.00 41.19 ? 252 TYR B C 1 ATOM 3941 O O . TYR B 1 186 ? 33.694 75.451 76.960 1.00 40.24 ? 252 TYR B O 1 ATOM 3942 C CB . TYR B 1 186 ? 35.711 78.291 77.035 1.00 33.57 ? 252 TYR B CB 1 ATOM 3943 C CG . TYR B 1 186 ? 34.383 79.007 76.966 1.00 33.42 ? 252 TYR B CG 1 ATOM 3944 C CD1 . TYR B 1 186 ? 33.510 79.013 78.056 1.00 35.91 ? 252 TYR B CD1 1 ATOM 3945 C CD2 . TYR B 1 186 ? 34.034 79.760 75.850 1.00 33.24 ? 252 TYR B CD2 1 ATOM 3946 C CE1 . TYR B 1 186 ? 32.299 79.716 78.015 1.00 35.50 ? 252 TYR B CE1 1 ATOM 3947 C CE2 . TYR B 1 186 ? 32.849 80.499 75.814 1.00 33.35 ? 252 TYR B CE2 1 ATOM 3948 C CZ . TYR B 1 186 ? 31.968 80.445 76.883 1.00 39.27 ? 252 TYR B CZ 1 ATOM 3949 O OH . TYR B 1 186 ? 30.787 81.145 76.812 1.00 42.07 ? 252 TYR B OH 1 ATOM 3950 N N . GLU B 1 187 ? 35.025 75.857 78.710 1.00 40.09 ? 253 GLU B N 1 ATOM 3951 C CA . GLU B 1 187 ? 34.123 75.166 79.602 1.00 41.72 ? 253 GLU B CA 1 ATOM 3952 C C . GLU B 1 187 ? 33.979 75.915 80.903 1.00 44.16 ? 253 GLU B C 1 ATOM 3953 O O . GLU B 1 187 ? 34.837 76.725 81.291 1.00 42.54 ? 253 GLU B O 1 ATOM 3954 C CB . GLU B 1 187 ? 34.482 73.686 79.785 1.00 44.10 ? 253 GLU B CB 1 ATOM 3955 C CG . GLU B 1 187 ? 35.931 73.406 80.098 1.00 55.68 ? 253 GLU B CG 1 ATOM 3956 C CD . GLU B 1 187 ? 36.299 71.936 80.038 1.00 84.47 ? 253 GLU B CD 1 ATOM 3957 O OE1 . GLU B 1 187 ? 35.491 71.125 79.527 1.00 93.15 ? 253 GLU B OE1 1 ATOM 3958 O OE2 . GLU B 1 187 ? 37.419 71.598 80.481 1.00 76.38 ? 253 GLU B OE2 1 ATOM 3959 N N . GLY B 1 188 ? 32.841 75.680 81.530 1.00 40.40 ? 254 GLY B N 1 ATOM 3960 C CA . GLY B 1 188 ? 32.497 76.342 82.773 1.00 39.75 ? 254 GLY B CA 1 ATOM 3961 C C . GLY B 1 188 ? 32.074 77.748 82.461 1.00 43.01 ? 254 GLY B C 1 ATOM 3962 O O . GLY B 1 188 ? 31.626 78.027 81.339 1.00 43.93 ? 254 GLY B O 1 ATOM 3963 N N . ASN B 1 189 ? 32.251 78.643 83.427 1.00 38.50 ? 255 ASN B N 1 ATOM 3964 C CA . ASN B 1 189 ? 31.889 80.049 83.259 1.00 37.81 ? 255 ASN B CA 1 ATOM 3965 C C . ASN B 1 189 ? 33.092 80.946 83.340 1.00 38.61 ? 255 ASN B C 1 ATOM 3966 O O . ASN B 1 189 ? 34.117 80.580 83.899 1.00 38.97 ? 255 ASN B O 1 ATOM 3967 C CB . ASN B 1 189 ? 30.836 80.512 84.304 1.00 36.14 ? 255 ASN B CB 1 ATOM 3968 C CG . ASN B 1 189 ? 29.589 79.682 84.337 1.00 44.50 ? 255 ASN B CG 1 ATOM 3969 O OD1 . ASN B 1 189 ? 29.303 78.995 85.317 1.00 46.13 ? 255 ASN B OD1 1 ATOM 3970 N ND2 . ASN B 1 189 ? 28.827 79.710 83.268 1.00 37.96 ? 255 ASN B ND2 1 ATOM 3971 N N . PHE B 1 190 ? 32.933 82.156 82.826 1.00 33.22 ? 256 PHE B N 1 ATOM 3972 C CA . PHE B 1 190 ? 33.973 83.159 82.871 1.00 31.88 ? 256 PHE B CA 1 ATOM 3973 C C . PHE B 1 190 ? 33.997 83.805 84.226 1.00 33.18 ? 256 PHE B C 1 ATOM 3974 O O . PHE B 1 190 ? 32.956 83.954 84.876 1.00 31.80 ? 256 PHE B O 1 ATOM 3975 C CB . PHE B 1 190 ? 33.675 84.283 81.835 1.00 33.44 ? 256 PHE B CB 1 ATOM 3976 C CG . PHE B 1 190 ? 33.936 83.960 80.386 1.00 34.01 ? 256 PHE B CG 1 ATOM 3977 C CD1 . PHE B 1 190 ? 35.237 83.881 79.899 1.00 36.64 ? 256 PHE B CD1 1 ATOM 3978 C CD2 . PHE B 1 190 ? 32.883 83.816 79.489 1.00 34.37 ? 256 PHE B CD2 1 ATOM 3979 C CE1 . PHE B 1 190 ? 35.479 83.585 78.553 1.00 36.64 ? 256 PHE B CE1 1 ATOM 3980 C CE2 . PHE B 1 190 ? 33.123 83.504 78.148 1.00 36.58 ? 256 PHE B CE2 1 ATOM 3981 C CZ . PHE B 1 190 ? 34.421 83.394 77.689 1.00 35.34 ? 256 PHE B CZ 1 ATOM 3982 N N . HIS B 1 191 ? 35.197 84.186 84.635 1.00 29.92 ? 257 HIS B N 1 ATOM 3983 C CA A HIS B 1 191 ? 35.474 85.002 85.832 0.50 28.68 ? 257 HIS B CA 1 ATOM 3984 C CA B HIS B 1 191 ? 35.423 84.999 85.811 0.50 29.60 ? 257 HIS B CA 1 ATOM 3985 C C . HIS B 1 191 ? 36.258 86.184 85.289 1.00 33.68 ? 257 HIS B C 1 ATOM 3986 O O . HIS B 1 191 ? 37.194 86.001 84.485 1.00 33.55 ? 257 HIS B O 1 ATOM 3987 C CB A HIS B 1 191 ? 36.264 84.292 86.949 0.50 27.80 ? 257 HIS B CB 1 ATOM 3988 C CB B HIS B 1 191 ? 36.008 84.204 86.989 0.50 29.63 ? 257 HIS B CB 1 ATOM 3989 C CG A HIS B 1 191 ? 36.649 85.212 88.081 0.50 29.92 ? 257 HIS B CG 1 ATOM 3990 C CG B HIS B 1 191 ? 35.152 83.026 87.378 0.50 32.63 ? 257 HIS B CG 1 ATOM 3991 N ND1 A HIS B 1 191 ? 35.745 85.549 89.084 0.50 30.90 ? 257 HIS B ND1 1 ATOM 3992 N ND1 B HIS B 1 191 ? 33.850 83.192 87.838 0.50 33.96 ? 257 HIS B ND1 1 ATOM 3993 C CD2 A HIS B 1 191 ? 37.821 85.853 88.322 0.50 30.33 ? 257 HIS B CD2 1 ATOM 3994 C CD2 B HIS B 1 191 ? 35.428 81.697 87.331 0.50 33.75 ? 257 HIS B CD2 1 ATOM 3995 C CE1 A HIS B 1 191 ? 36.392 86.380 89.888 0.50 29.25 ? 257 HIS B CE1 1 ATOM 3996 C CE1 B HIS B 1 191 ? 33.385 81.972 88.052 0.50 32.97 ? 257 HIS B CE1 1 ATOM 3997 N NE2 A HIS B 1 191 ? 37.639 86.601 89.469 0.50 29.36 ? 257 HIS B NE2 1 ATOM 3998 N NE2 B HIS B 1 191 ? 34.298 81.040 87.769 0.50 33.17 ? 257 HIS B NE2 1 ATOM 3999 N N . TYR B 1 192 ? 35.809 87.393 85.631 1.00 28.95 ? 258 TYR B N 1 ATOM 4000 C CA . TYR B 1 192 ? 36.369 88.633 85.147 1.00 27.55 ? 258 TYR B CA 1 ATOM 4001 C C . TYR B 1 192 ? 37.247 89.364 86.140 1.00 34.99 ? 258 TYR B C 1 ATOM 4002 O O . TYR B 1 192 ? 37.090 89.234 87.355 1.00 35.78 ? 258 TYR B O 1 ATOM 4003 C CB . TYR B 1 192 ? 35.236 89.539 84.651 1.00 27.66 ? 258 TYR B CB 1 ATOM 4004 C CG . TYR B 1 192 ? 34.333 88.907 83.602 1.00 26.39 ? 258 TYR B CG 1 ATOM 4005 C CD1 . TYR B 1 192 ? 33.270 88.084 83.965 1.00 25.94 ? 258 TYR B CD1 1 ATOM 4006 C CD2 . TYR B 1 192 ? 34.533 89.149 82.250 1.00 27.23 ? 258 TYR B CD2 1 ATOM 4007 C CE1 . TYR B 1 192 ? 32.450 87.490 83.000 1.00 26.77 ? 258 TYR B CE1 1 ATOM 4008 C CE2 . TYR B 1 192 ? 33.723 88.555 81.278 1.00 27.72 ? 258 TYR B CE2 1 ATOM 4009 C CZ . TYR B 1 192 ? 32.684 87.730 81.658 1.00 32.77 ? 258 TYR B CZ 1 ATOM 4010 O OH . TYR B 1 192 ? 31.888 87.167 80.699 1.00 35.51 ? 258 TYR B OH 1 ATOM 4011 N N . ILE B 1 193 ? 38.194 90.131 85.595 1.00 32.45 ? 259 ILE B N 1 ATOM 4012 C CA . ILE B 1 193 ? 39.136 90.997 86.299 1.00 32.43 ? 259 ILE B CA 1 ATOM 4013 C C . ILE B 1 193 ? 39.008 92.345 85.594 1.00 37.69 ? 259 ILE B C 1 ATOM 4014 O O . ILE B 1 193 ? 39.056 92.394 84.365 1.00 37.15 ? 259 ILE B O 1 ATOM 4015 C CB . ILE B 1 193 ? 40.600 90.453 86.285 1.00 34.43 ? 259 ILE B CB 1 ATOM 4016 C CG1 . ILE B 1 193 ? 40.665 88.988 86.745 1.00 34.66 ? 259 ILE B CG1 1 ATOM 4017 C CG2 . ILE B 1 193 ? 41.526 91.315 87.139 1.00 34.31 ? 259 ILE B CG2 1 ATOM 4018 C CD1 . ILE B 1 193 ? 40.735 87.989 85.645 1.00 34.10 ? 259 ILE B CD1 1 ATOM 4019 N N . ASN B 1 194 ? 38.765 93.412 86.351 1.00 34.99 ? 260 ASN B N 1 ATOM 4020 C CA . ASN B 1 194 ? 38.614 94.735 85.763 1.00 35.41 ? 260 ASN B CA 1 ATOM 4021 C C . ASN B 1 194 ? 39.963 95.300 85.378 1.00 39.49 ? 260 ASN B C 1 ATOM 4022 O O . ASN B 1 194 ? 40.974 94.942 85.988 1.00 38.44 ? 260 ASN B O 1 ATOM 4023 C CB . ASN B 1 194 ? 37.882 95.678 86.729 1.00 36.23 ? 260 ASN B CB 1 ATOM 4024 C CG . ASN B 1 194 ? 36.516 95.194 87.177 1.00 49.34 ? 260 ASN B CG 1 ATOM 4025 O OD1 . ASN B 1 194 ? 36.145 95.386 88.321 1.00 54.98 ? 260 ASN B OD1 1 ATOM 4026 N ND2 . ASN B 1 194 ? 35.709 94.563 86.302 1.00 31.01 ? 260 ASN B ND2 1 ATOM 4027 N N . LEU B 1 195 ? 39.979 96.187 84.369 1.00 37.15 ? 261 LEU B N 1 ATOM 4028 C CA . LEU B 1 195 ? 41.204 96.857 83.930 1.00 37.08 ? 261 LEU B CA 1 ATOM 4029 C C . LEU B 1 195 ? 41.605 97.874 84.972 1.00 42.95 ? 261 LEU B C 1 ATOM 4030 O O . LEU B 1 195 ? 40.723 98.476 85.587 1.00 42.55 ? 261 LEU B O 1 ATOM 4031 C CB . LEU B 1 195 ? 41.005 97.579 82.564 1.00 36.01 ? 261 LEU B CB 1 ATOM 4032 C CG . LEU B 1 195 ? 40.567 96.718 81.356 1.00 38.18 ? 261 LEU B CG 1 ATOM 4033 C CD1 . LEU B 1 195 ? 40.512 97.553 80.093 1.00 37.38 ? 261 LEU B CD1 1 ATOM 4034 C CD2 . LEU B 1 195 ? 41.428 95.481 81.181 1.00 33.46 ? 261 LEU B CD2 1 ATOM 4035 N N . ILE B 1 196 ? 42.920 98.096 85.146 1.00 42.08 ? 262 ILE B N 1 ATOM 4036 C CA . ILE B 1 196 ? 43.461 99.132 86.036 1.00 43.74 ? 262 ILE B CA 1 ATOM 4037 C C . ILE B 1 196 ? 42.816 100.471 85.604 1.00 49.74 ? 262 ILE B C 1 ATOM 4038 O O . ILE B 1 196 ? 42.317 101.228 86.432 1.00 51.58 ? 262 ILE B O 1 ATOM 4039 C CB . ILE B 1 196 ? 45.017 99.227 85.898 1.00 47.79 ? 262 ILE B CB 1 ATOM 4040 C CG1 . ILE B 1 196 ? 45.738 97.912 86.304 1.00 47.71 ? 262 ILE B CG1 1 ATOM 4041 C CG2 . ILE B 1 196 ? 45.589 100.473 86.655 1.00 49.32 ? 262 ILE B CG2 1 ATOM 4042 C CD1 . ILE B 1 196 ? 45.617 97.544 87.700 1.00 57.47 ? 262 ILE B CD1 1 ATOM 4043 N N . LYS B 1 197 ? 42.815 100.721 84.287 1.00 46.08 ? 263 LYS B N 1 ATOM 4044 C CA . LYS B 1 197 ? 42.294 101.909 83.619 1.00 45.21 ? 263 LYS B CA 1 ATOM 4045 C C . LYS B 1 197 ? 42.012 101.577 82.163 1.00 49.77 ? 263 LYS B C 1 ATOM 4046 O O . LYS B 1 197 ? 42.718 100.754 81.554 1.00 49.54 ? 263 LYS B O 1 ATOM 4047 C CB . LYS B 1 197 ? 43.323 103.070 83.672 1.00 46.14 ? 263 LYS B CB 1 ATOM 4048 C CG . LYS B 1 197 ? 44.709 102.712 83.125 1.00 56.46 ? 263 LYS B CG 1 ATOM 4049 C CD . LYS B 1 197 ? 45.606 103.921 82.899 1.00 61.50 ? 263 LYS B CD 1 ATOM 4050 C CE . LYS B 1 197 ? 46.939 103.528 82.300 1.00 68.35 ? 263 LYS B CE 1 ATOM 4051 N NZ . LYS B 1 197 ? 47.755 102.701 83.233 1.00 72.88 ? 263 LYS B NZ 1 ATOM 4052 N N . THR B 1 198 ? 41.020 102.276 81.590 1.00 45.07 ? 264 THR B N 1 ATOM 4053 C CA . THR B 1 198 ? 40.662 102.168 80.181 1.00 44.24 ? 264 THR B CA 1 ATOM 4054 C C . THR B 1 198 ? 41.878 102.613 79.316 1.00 45.62 ? 264 THR B C 1 ATOM 4055 O O . THR B 1 198 ? 42.743 103.375 79.786 1.00 43.42 ? 264 THR B O 1 ATOM 4056 C CB . THR B 1 198 ? 39.346 102.927 79.921 1.00 50.84 ? 264 THR B CB 1 ATOM 4057 O OG1 . THR B 1 198 ? 38.795 102.536 78.664 1.00 53.09 ? 264 THR B OG1 1 ATOM 4058 C CG2 . THR B 1 198 ? 39.492 104.452 80.015 1.00 46.55 ? 264 THR B CG2 1 ATOM 4059 N N . GLY B 1 199 ? 41.958 102.091 78.099 1.00 40.77 ? 265 GLY B N 1 ATOM 4060 C CA . GLY B 1 199 ? 43.045 102.443 77.198 1.00 40.59 ? 265 GLY B CA 1 ATOM 4061 C C . GLY B 1 199 ? 44.149 101.420 77.072 1.00 45.15 ? 265 GLY B C 1 ATOM 4062 O O . GLY B 1 199 ? 44.946 101.512 76.139 1.00 44.80 ? 265 GLY B O 1 ATOM 4063 N N . VAL B 1 200 ? 44.228 100.454 78.020 1.00 42.41 ? 266 VAL B N 1 ATOM 4064 C CA . VAL B 1 200 ? 45.240 99.376 78.053 1.00 41.57 ? 266 VAL B CA 1 ATOM 4065 C C . VAL B 1 200 ? 44.570 98.071 78.526 1.00 43.66 ? 266 VAL B C 1 ATOM 4066 O O . VAL B 1 200 ? 43.913 98.082 79.566 1.00 43.55 ? 266 VAL B O 1 ATOM 4067 C CB . VAL B 1 200 ? 46.482 99.686 78.961 1.00 45.83 ? 266 VAL B CB 1 ATOM 4068 C CG1 . VAL B 1 200 ? 47.672 98.816 78.583 1.00 45.04 ? 266 VAL B CG1 1 ATOM 4069 C CG2 . VAL B 1 200 ? 46.889 101.154 78.927 1.00 46.50 ? 266 VAL B CG2 1 ATOM 4070 N N . TRP B 1 201 ? 44.788 96.937 77.804 1.00 37.71 ? 267 TRP B N 1 ATOM 4071 C CA . TRP B 1 201 ? 44.290 95.610 78.206 1.00 35.35 ? 267 TRP B CA 1 ATOM 4072 C C . TRP B 1 201 ? 45.269 95.076 79.273 1.00 38.57 ? 267 TRP B C 1 ATOM 4073 O O . TRP B 1 201 ? 46.011 94.119 79.048 1.00 36.31 ? 267 TRP B O 1 ATOM 4074 C CB . TRP B 1 201 ? 44.156 94.644 77.003 1.00 32.47 ? 267 TRP B CB 1 ATOM 4075 C CG . TRP B 1 201 ? 43.075 95.004 76.030 1.00 31.97 ? 267 TRP B CG 1 ATOM 4076 C CD1 . TRP B 1 201 ? 43.238 95.409 74.741 1.00 34.64 ? 267 TRP B CD1 1 ATOM 4077 C CD2 . TRP B 1 201 ? 41.661 94.987 76.270 1.00 31.78 ? 267 TRP B CD2 1 ATOM 4078 N NE1 . TRP B 1 201 ? 42.007 95.621 74.149 1.00 34.26 ? 267 TRP B NE1 1 ATOM 4079 C CE2 . TRP B 1 201 ? 41.024 95.395 75.073 1.00 35.04 ? 267 TRP B CE2 1 ATOM 4080 C CE3 . TRP B 1 201 ? 40.860 94.697 77.398 1.00 32.73 ? 267 TRP B CE3 1 ATOM 4081 C CZ2 . TRP B 1 201 ? 39.632 95.482 74.954 1.00 33.35 ? 267 TRP B CZ2 1 ATOM 4082 C CZ3 . TRP B 1 201 ? 39.478 94.808 77.281 1.00 33.27 ? 267 TRP B CZ3 1 ATOM 4083 C CH2 . TRP B 1 201 ? 38.879 95.179 76.069 1.00 33.78 ? 267 TRP B CH2 1 ATOM 4084 N N . GLN B 1 202 ? 45.299 95.774 80.422 1.00 36.36 ? 268 GLN B N 1 ATOM 4085 C CA . GLN B 1 202 ? 46.203 95.504 81.537 1.00 35.39 ? 268 GLN B CA 1 ATOM 4086 C C . GLN B 1 202 ? 45.415 95.428 82.816 1.00 38.18 ? 268 GLN B C 1 ATOM 4087 O O . GLN B 1 202 ? 44.558 96.277 83.075 1.00 39.28 ? 268 GLN B O 1 ATOM 4088 C CB . GLN B 1 202 ? 47.279 96.604 81.613 1.00 35.78 ? 268 GLN B CB 1 ATOM 4089 C CG . GLN B 1 202 ? 48.419 96.288 82.583 1.00 40.16 ? 268 GLN B CG 1 ATOM 4090 C CD . GLN B 1 202 ? 49.507 97.312 82.499 1.00 46.59 ? 268 GLN B CD 1 ATOM 4091 O OE1 . GLN B 1 202 ? 49.257 98.520 82.550 1.00 43.05 ? 268 GLN B OE1 1 ATOM 4092 N NE2 . GLN B 1 202 ? 50.735 96.856 82.360 1.00 38.40 ? 268 GLN B NE2 1 ATOM 4093 N N . ILE B 1 203 ? 45.705 94.407 83.614 1.00 33.60 ? 269 ILE B N 1 ATOM 4094 C CA . ILE B 1 203 ? 45.018 94.135 84.877 1.00 33.49 ? 269 ILE B CA 1 ATOM 4095 C C . ILE B 1 203 ? 46.005 94.032 86.035 1.00 40.56 ? 269 ILE B C 1 ATOM 4096 O O . ILE B 1 203 ? 47.207 93.813 85.824 1.00 39.44 ? 269 ILE B O 1 ATOM 4097 C CB . ILE B 1 203 ? 44.160 92.820 84.765 1.00 35.40 ? 269 ILE B CB 1 ATOM 4098 C CG1 . ILE B 1 203 ? 45.049 91.575 84.411 1.00 33.18 ? 269 ILE B CG1 1 ATOM 4099 C CG2 . ILE B 1 203 ? 42.960 92.999 83.795 1.00 34.77 ? 269 ILE B CG2 1 ATOM 4100 C CD1 . ILE B 1 203 ? 44.324 90.220 84.438 1.00 33.27 ? 269 ILE B CD1 1 ATOM 4101 N N . GLN B 1 204 ? 45.470 94.123 87.272 1.00 38.37 ? 270 GLN B N 1 ATOM 4102 C CA . GLN B 1 204 ? 46.263 93.954 88.482 1.00 37.56 ? 270 GLN B CA 1 ATOM 4103 C C . GLN B 1 204 ? 46.481 92.462 88.683 1.00 38.56 ? 270 GLN B C 1 ATOM 4104 O O . GLN B 1 204 ? 45.574 91.658 88.448 1.00 37.06 ? 270 GLN B O 1 ATOM 4105 C CB . GLN B 1 204 ? 45.525 94.563 89.700 1.00 39.39 ? 270 GLN B CB 1 ATOM 4106 C CG . GLN B 1 204 ? 46.347 94.657 90.999 1.00 49.59 ? 270 GLN B CG 1 ATOM 4107 C CD . GLN B 1 204 ? 47.468 95.679 90.951 1.00 67.80 ? 270 GLN B CD 1 ATOM 4108 O OE1 . GLN B 1 204 ? 47.305 96.826 90.505 1.00 64.04 ? 270 GLN B OE1 1 ATOM 4109 N NE2 . GLN B 1 204 ? 48.631 95.293 91.446 1.00 55.46 ? 270 GLN B NE2 1 ATOM 4110 N N . MET B 1 205 ? 47.694 92.094 89.084 1.00 36.28 ? 271 MET B N 1 ATOM 4111 C CA . MET B 1 205 ? 48.051 90.717 89.417 1.00 36.58 ? 271 MET B CA 1 ATOM 4112 C C . MET B 1 205 ? 48.451 90.729 90.902 1.00 44.64 ? 271 MET B C 1 ATOM 4113 O O . MET B 1 205 ? 49.293 91.531 91.308 1.00 43.26 ? 271 MET B O 1 ATOM 4114 C CB . MET B 1 205 ? 49.174 90.186 88.511 1.00 37.83 ? 271 MET B CB 1 ATOM 4115 C CG . MET B 1 205 ? 49.536 88.724 88.796 1.00 39.88 ? 271 MET B CG 1 ATOM 4116 S SD . MET B 1 205 ? 50.102 87.757 87.352 1.00 42.44 ? 271 MET B SD 1 ATOM 4117 C CE . MET B 1 205 ? 51.505 88.688 86.853 1.00 38.48 ? 271 MET B CE 1 ATOM 4118 N N . LYS B 1 206 ? 47.815 89.871 91.703 1.00 45.23 ? 272 LYS B N 1 ATOM 4119 C CA . LYS B 1 206 ? 48.017 89.787 93.155 1.00 46.71 ? 272 LYS B CA 1 ATOM 4120 C C . LYS B 1 206 ? 49.249 88.996 93.591 1.00 51.43 ? 272 LYS B C 1 ATOM 4121 O O . LYS B 1 206 ? 49.717 89.218 94.694 1.00 53.92 ? 272 LYS B O 1 ATOM 4122 C CB . LYS B 1 206 ? 46.751 89.240 93.848 1.00 50.47 ? 272 LYS B CB 1 ATOM 4123 N N . GLY B 1 207 ? 49.765 88.115 92.740 1.00 46.92 ? 273 GLY B N 1 ATOM 4124 C CA . GLY B 1 207 ? 50.942 87.297 93.020 1.00 45.85 ? 273 GLY B CA 1 ATOM 4125 C C . GLY B 1 207 ? 51.189 86.170 92.033 1.00 48.44 ? 273 GLY B C 1 ATOM 4126 O O . GLY B 1 207 ? 50.260 85.717 91.362 1.00 47.13 ? 273 GLY B O 1 ATOM 4127 N N . VAL B 1 208 ? 52.459 85.694 91.952 1.00 44.71 ? 274 VAL B N 1 ATOM 4128 C CA . VAL B 1 208 ? 52.883 84.588 91.074 1.00 43.36 ? 274 VAL B CA 1 ATOM 4129 C C . VAL B 1 208 ? 53.509 83.487 91.942 1.00 47.91 ? 274 VAL B C 1 ATOM 4130 O O . VAL B 1 208 ? 54.508 83.741 92.628 1.00 47.84 ? 274 VAL B O 1 ATOM 4131 C CB . VAL B 1 208 ? 53.825 85.032 89.914 1.00 46.23 ? 274 VAL B CB 1 ATOM 4132 C CG1 . VAL B 1 208 ? 54.194 83.840 89.026 1.00 46.15 ? 274 VAL B CG1 1 ATOM 4133 C CG2 . VAL B 1 208 ? 53.194 86.141 89.074 1.00 45.47 ? 274 VAL B CG2 1 ATOM 4134 N N . SER B 1 209 ? 52.912 82.279 91.921 1.00 44.93 ? 275 SER B N 1 ATOM 4135 C CA . SER B 1 209 ? 53.342 81.121 92.710 1.00 45.83 ? 275 SER B CA 1 ATOM 4136 C C . SER B 1 209 ? 54.026 80.049 91.860 1.00 53.07 ? 275 SER B C 1 ATOM 4137 O O . SER B 1 209 ? 53.531 79.689 90.792 1.00 51.20 ? 275 SER B O 1 ATOM 4138 C CB . SER B 1 209 ? 52.155 80.492 93.437 1.00 48.20 ? 275 SER B CB 1 ATOM 4139 O OG . SER B 1 209 ? 51.460 81.449 94.208 1.00 57.97 ? 275 SER B OG 1 ATOM 4140 N N . VAL B 1 210 ? 55.144 79.525 92.364 1.00 54.09 ? 276 VAL B N 1 ATOM 4141 C CA . VAL B 1 210 ? 55.904 78.442 91.743 1.00 56.27 ? 276 VAL B CA 1 ATOM 4142 C C . VAL B 1 210 ? 55.842 77.278 92.753 1.00 65.38 ? 276 VAL B C 1 ATOM 4143 O O . VAL B 1 210 ? 56.396 77.355 93.849 1.00 65.49 ? 276 VAL B O 1 ATOM 4144 C CB . VAL B 1 210 ? 57.346 78.861 91.346 1.00 59.71 ? 276 VAL B CB 1 ATOM 4145 C CG1 . VAL B 1 210 ? 57.995 77.801 90.480 1.00 59.63 ? 276 VAL B CG1 1 ATOM 4146 C CG2 . VAL B 1 210 ? 57.359 80.188 90.594 1.00 59.39 ? 276 VAL B CG2 1 ATOM 4147 N N . GLY B 1 211 ? 55.080 76.259 92.412 1.00 65.69 ? 277 GLY B N 1 ATOM 4148 C CA . GLY B 1 211 ? 54.859 75.133 93.310 1.00 68.02 ? 277 GLY B CA 1 ATOM 4149 C C . GLY B 1 211 ? 53.814 75.510 94.339 1.00 77.35 ? 277 GLY B C 1 ATOM 4150 O O . GLY B 1 211 ? 52.704 75.887 93.955 1.00 76.93 ? 277 GLY B O 1 ATOM 4151 N N . SER B 1 212 ? 54.172 75.521 95.634 1.00 77.75 ? 278 SER B N 1 ATOM 4152 C CA . SER B 1 212 ? 53.239 75.920 96.701 1.00 78.93 ? 278 SER B CA 1 ATOM 4153 C C . SER B 1 212 ? 53.508 77.362 97.203 1.00 84.43 ? 278 SER B C 1 ATOM 4154 O O . SER B 1 212 ? 52.576 78.167 97.292 1.00 83.20 ? 278 SER B O 1 ATOM 4155 C CB . SER B 1 212 ? 53.254 74.905 97.840 1.00 82.60 ? 278 SER B CB 1 ATOM 4156 O OG . SER B 1 212 ? 54.581 74.581 98.223 1.00 91.24 ? 278 SER B OG 1 ATOM 4157 N N . SER B 1 213 ? 54.795 77.691 97.436 1.00 82.09 ? 279 SER B N 1 ATOM 4158 C CA . SER B 1 213 ? 55.268 79.013 97.846 1.00 81.74 ? 279 SER B CA 1 ATOM 4159 C C . SER B 1 213 ? 55.001 80.051 96.730 1.00 84.27 ? 279 SER B C 1 ATOM 4160 O O . SER B 1 213 ? 55.109 79.703 95.549 1.00 84.44 ? 279 SER B O 1 ATOM 4161 C CB . SER B 1 213 ? 56.766 78.956 98.152 1.00 85.52 ? 279 SER B CB 1 ATOM 4162 O OG . SER B 1 213 ? 57.535 78.447 97.070 1.00 92.71 ? 279 SER B OG 1 ATOM 4163 N N . THR B 1 214 ? 54.645 81.313 97.103 1.00 78.04 ? 280 THR B N 1 ATOM 4164 C CA . THR B 1 214 ? 54.428 82.398 96.140 1.00 76.03 ? 280 THR B CA 1 ATOM 4165 C C . THR B 1 214 ? 55.810 82.809 95.608 1.00 76.94 ? 280 THR B C 1 ATOM 4166 O O . THR B 1 214 ? 56.229 82.314 94.558 1.00 77.29 ? 280 THR B O 1 ATOM 4167 C CB . THR B 1 214 ? 53.530 83.519 96.726 1.00 79.99 ? 280 THR B CB 1 ATOM 4168 O OG1 . THR B 1 214 ? 52.242 82.966 97.025 1.00 78.45 ? 280 THR B OG1 1 ATOM 4169 C CG2 . THR B 1 214 ? 53.351 84.711 95.771 1.00 75.45 ? 280 THR B CG2 1 ATOM 4170 N N . LEU B 1 215 ? 56.542 83.634 96.374 1.00 70.20 ? 281 LEU B N 1 ATOM 4171 C CA . LEU B 1 215 ? 57.900 84.123 96.083 1.00 68.38 ? 281 LEU B CA 1 ATOM 4172 C C . LEU B 1 215 ? 57.956 85.251 95.064 1.00 65.44 ? 281 LEU B C 1 ATOM 4173 O O . LEU B 1 215 ? 58.871 86.070 95.160 1.00 65.18 ? 281 LEU B O 1 ATOM 4174 C CB . LEU B 1 215 ? 58.887 83.001 95.687 1.00 68.90 ? 281 LEU B CB 1 ATOM 4175 N N . LEU B 1 216 ? 57.020 85.313 94.097 1.00 57.22 ? 282 LEU B N 1 ATOM 4176 C CA . LEU B 1 216 ? 57.050 86.393 93.108 1.00 55.45 ? 282 LEU B CA 1 ATOM 4177 C C . LEU B 1 216 ? 55.802 87.208 93.138 1.00 57.98 ? 282 LEU B C 1 ATOM 4178 O O . LEU B 1 216 ? 54.730 86.666 93.404 1.00 57.19 ? 282 LEU B O 1 ATOM 4179 C CB . LEU B 1 216 ? 57.277 85.866 91.682 1.00 55.51 ? 282 LEU B CB 1 ATOM 4180 C CG . LEU B 1 216 ? 58.560 85.091 91.416 1.00 60.53 ? 282 LEU B CG 1 ATOM 4181 C CD1 . LEU B 1 216 ? 58.447 84.327 90.130 1.00 61.18 ? 282 LEU B CD1 1 ATOM 4182 C CD2 . LEU B 1 216 ? 59.761 86.016 91.366 1.00 63.38 ? 282 LEU B CD2 1 ATOM 4183 N N . CYS B 1 217 ? 55.922 88.516 92.823 1.00 55.46 ? 283 CYS B N 1 ATOM 4184 C CA . CYS B 1 217 ? 54.793 89.443 92.755 1.00 56.09 ? 283 CYS B CA 1 ATOM 4185 C C . CYS B 1 217 ? 54.086 89.494 94.138 1.00 60.64 ? 283 CYS B C 1 ATOM 4186 O O . CYS B 1 217 ? 52.879 89.707 94.228 1.00 59.68 ? 283 CYS B O 1 ATOM 4187 C CB . CYS B 1 217 ? 53.843 89.010 91.632 1.00 56.71 ? 283 CYS B CB 1 ATOM 4188 S SG . CYS B 1 217 ? 52.521 90.184 91.259 1.00 60.65 ? 283 CYS B SG 1 ATOM 4189 N N . GLU B 1 218 ? 54.874 89.309 95.214 1.00 59.41 ? 284 GLU B N 1 ATOM 4190 C CA . GLU B 1 218 ? 54.431 89.284 96.612 1.00 59.72 ? 284 GLU B CA 1 ATOM 4191 C C . GLU B 1 218 ? 53.640 90.532 97.019 1.00 62.84 ? 284 GLU B C 1 ATOM 4192 O O . GLU B 1 218 ? 52.648 90.403 97.733 1.00 61.19 ? 284 GLU B O 1 ATOM 4193 C CB . GLU B 1 218 ? 55.618 89.032 97.548 1.00 61.20 ? 284 GLU B CB 1 ATOM 4194 N N . ASP B 1 219 ? 54.023 91.720 96.500 1.00 60.29 ? 285 ASP B N 1 ATOM 4195 C CA . ASP B 1 219 ? 53.319 92.974 96.797 1.00 60.42 ? 285 ASP B CA 1 ATOM 4196 C C . ASP B 1 219 ? 52.444 93.496 95.626 1.00 64.13 ? 285 ASP B C 1 ATOM 4197 O O . ASP B 1 219 ? 52.001 94.653 95.653 1.00 63.43 ? 285 ASP B O 1 ATOM 4198 C CB . ASP B 1 219 ? 54.309 94.053 97.290 1.00 62.82 ? 285 ASP B CB 1 ATOM 4199 C CG . ASP B 1 219 ? 55.014 93.721 98.607 1.00 77.71 ? 285 ASP B CG 1 ATOM 4200 O OD1 . ASP B 1 219 ? 54.322 93.296 99.570 1.00 79.39 ? 285 ASP B OD1 1 ATOM 4201 O OD2 . ASP B 1 219 ? 56.248 93.908 98.683 1.00 83.82 ? 285 ASP B OD2 1 ATOM 4202 N N . GLY B 1 220 ? 52.176 92.636 94.640 1.00 59.55 ? 286 GLY B N 1 ATOM 4203 C CA . GLY B 1 220 ? 51.345 92.994 93.495 1.00 58.55 ? 286 GLY B CA 1 ATOM 4204 C C . GLY B 1 220 ? 52.104 93.466 92.268 1.00 59.85 ? 286 GLY B C 1 ATOM 4205 O O . GLY B 1 220 ? 53.162 94.092 92.393 1.00 58.24 ? 286 GLY B O 1 ATOM 4206 N N . CYS B 1 221 ? 51.545 93.130 91.061 1.00 55.65 ? 287 CYS B N 1 ATOM 4207 C CA . CYS B 1 221 ? 52.012 93.403 89.674 1.00 54.64 ? 287 CYS B CA 1 ATOM 4208 C C . CYS B 1 221 ? 50.967 94.032 88.845 1.00 51.99 ? 287 CYS B C 1 ATOM 4209 O O . CYS B 1 221 ? 49.785 94.029 89.160 1.00 51.62 ? 287 CYS B O 1 ATOM 4210 C CB . CYS B 1 221 ? 52.399 92.122 88.945 1.00 56.02 ? 287 CYS B CB 1 ATOM 4211 S SG . CYS B 1 221 ? 53.571 91.093 89.782 1.00 60.81 ? 287 CYS B SG 1 ATOM 4212 N N . LEU B 1 222 ? 51.406 94.198 87.613 1.00 44.18 ? 288 LEU B N 1 ATOM 4213 C CA . LEU B 1 222 ? 50.673 94.611 86.460 1.00 42.76 ? 288 LEU B CA 1 ATOM 4214 C C . LEU B 1 222 ? 50.825 93.426 85.512 1.00 46.54 ? 288 LEU B C 1 ATOM 4215 O O . LEU B 1 222 ? 51.903 92.808 85.456 1.00 45.27 ? 288 LEU B O 1 ATOM 4216 C CB . LEU B 1 222 ? 51.317 95.866 85.873 1.00 42.46 ? 288 LEU B CB 1 ATOM 4217 C CG . LEU B 1 222 ? 51.482 97.069 86.829 1.00 46.77 ? 288 LEU B CG 1 ATOM 4218 C CD1 . LEU B 1 222 ? 52.182 98.237 86.111 1.00 46.72 ? 288 LEU B CD1 1 ATOM 4219 C CD2 . LEU B 1 222 ? 50.130 97.533 87.385 1.00 47.94 ? 288 LEU B CD2 1 ATOM 4220 N N . ALA B 1 223 ? 49.711 93.050 84.853 1.00 42.56 ? 289 ALA B N 1 ATOM 4221 C CA . ALA B 1 223 ? 49.635 91.965 83.875 1.00 41.45 ? 289 ALA B CA 1 ATOM 4222 C C . ALA B 1 223 ? 48.880 92.422 82.609 1.00 44.72 ? 289 ALA B C 1 ATOM 4223 O O . ALA B 1 223 ? 47.672 92.675 82.638 1.00 42.93 ? 289 ALA B O 1 ATOM 4224 C CB . ALA B 1 223 ? 48.993 90.719 84.478 1.00 41.58 ? 289 ALA B CB 1 ATOM 4225 N N . LEU B 1 224 ? 49.638 92.546 81.502 1.00 41.12 ? 290 LEU B N 1 ATOM 4226 C CA . LEU B 1 224 ? 49.189 92.921 80.158 1.00 39.97 ? 290 LEU B CA 1 ATOM 4227 C C . LEU B 1 224 ? 48.635 91.655 79.465 1.00 39.53 ? 290 LEU B C 1 ATOM 4228 O O . LEU B 1 224 ? 49.363 90.674 79.365 1.00 38.69 ? 290 LEU B O 1 ATOM 4229 C CB . LEU B 1 224 ? 50.453 93.392 79.435 1.00 40.41 ? 290 LEU B CB 1 ATOM 4230 C CG . LEU B 1 224 ? 50.389 94.436 78.352 1.00 47.18 ? 290 LEU B CG 1 ATOM 4231 C CD1 . LEU B 1 224 ? 49.604 95.670 78.793 1.00 47.60 ? 290 LEU B CD1 1 ATOM 4232 C CD2 . LEU B 1 224 ? 51.813 94.848 77.951 1.00 49.75 ? 290 LEU B CD2 1 ATOM 4233 N N . VAL B 1 225 ? 47.369 91.654 79.011 1.00 32.78 ? 291 VAL B N 1 ATOM 4234 C CA . VAL B 1 225 ? 46.815 90.477 78.325 1.00 32.17 ? 291 VAL B CA 1 ATOM 4235 C C . VAL B 1 225 ? 46.989 90.724 76.816 1.00 36.37 ? 291 VAL B C 1 ATOM 4236 O O . VAL B 1 225 ? 46.297 91.539 76.214 1.00 35.98 ? 291 VAL B O 1 ATOM 4237 C CB . VAL B 1 225 ? 45.404 90.047 78.801 1.00 34.69 ? 291 VAL B CB 1 ATOM 4238 C CG1 . VAL B 1 225 ? 44.996 88.720 78.173 1.00 34.05 ? 291 VAL B CG1 1 ATOM 4239 C CG2 . VAL B 1 225 ? 45.363 89.933 80.327 1.00 34.28 ? 291 VAL B CG2 1 ATOM 4240 N N . ASP B 1 226 ? 48.027 90.090 76.258 1.00 33.03 ? 292 ASP B N 1 ATOM 4241 C CA . ASP B 1 226 ? 48.558 90.350 74.927 1.00 31.81 ? 292 ASP B CA 1 ATOM 4242 C C . ASP B 1 226 ? 48.448 89.191 73.947 1.00 35.21 ? 292 ASP B C 1 ATOM 4243 O O . ASP B 1 226 ? 49.253 88.270 73.986 1.00 35.15 ? 292 ASP B O 1 ATOM 4244 C CB . ASP B 1 226 ? 50.029 90.807 75.092 1.00 32.24 ? 292 ASP B CB 1 ATOM 4245 C CG . ASP B 1 226 ? 50.676 91.475 73.891 1.00 39.90 ? 292 ASP B CG 1 ATOM 4246 O OD1 . ASP B 1 226 ? 50.035 91.526 72.806 1.00 40.38 ? 292 ASP B OD1 1 ATOM 4247 O OD2 . ASP B 1 226 ? 51.825 91.936 74.028 1.00 43.42 ? 292 ASP B OD2 1 ATOM 4248 N N . THR B 1 227 ? 47.498 89.293 73.006 1.00 32.35 ? 293 THR B N 1 ATOM 4249 C CA . THR B 1 227 ? 47.239 88.272 71.989 1.00 32.48 ? 293 THR B CA 1 ATOM 4250 C C . THR B 1 227 ? 48.334 88.212 70.903 1.00 39.22 ? 293 THR B C 1 ATOM 4251 O O . THR B 1 227 ? 48.495 87.170 70.255 1.00 39.69 ? 293 THR B O 1 ATOM 4252 C CB . THR B 1 227 ? 45.825 88.429 71.409 1.00 36.42 ? 293 THR B CB 1 ATOM 4253 O OG1 . THR B 1 227 ? 45.699 89.705 70.791 1.00 32.01 ? 293 THR B OG1 1 ATOM 4254 C CG2 . THR B 1 227 ? 44.743 88.285 72.477 1.00 32.96 ? 293 THR B CG2 1 ATOM 4255 N N . GLY B 1 228 ? 49.091 89.302 70.755 1.00 36.67 ? 294 GLY B N 1 ATOM 4256 C CA . GLY B 1 228 ? 50.200 89.403 69.811 1.00 36.44 ? 294 GLY B CA 1 ATOM 4257 C C . GLY B 1 228 ? 51.503 88.836 70.344 1.00 40.70 ? 294 GLY B C 1 ATOM 4258 O O . GLY B 1 228 ? 52.368 88.464 69.558 1.00 41.12 ? 294 GLY B O 1 ATOM 4259 N N . ALA B 1 229 ? 51.646 88.727 71.682 1.00 35.69 ? 295 ALA B N 1 ATOM 4260 C CA . ALA B 1 229 ? 52.856 88.180 72.292 1.00 34.49 ? 295 ALA B CA 1 ATOM 4261 C C . ALA B 1 229 ? 52.806 86.647 72.302 1.00 39.29 ? 295 ALA B C 1 ATOM 4262 O O . ALA B 1 229 ? 51.772 86.056 72.622 1.00 40.49 ? 295 ALA B O 1 ATOM 4263 C CB . ALA B 1 229 ? 53.008 88.716 73.707 1.00 34.74 ? 295 ALA B CB 1 ATOM 4264 N N . SER B 1 230 ? 53.926 86.009 71.958 1.00 35.31 ? 296 SER B N 1 ATOM 4265 C CA . SER B 1 230 ? 54.059 84.550 71.884 1.00 33.60 ? 296 SER B CA 1 ATOM 4266 C C . SER B 1 230 ? 54.069 83.895 73.242 1.00 37.48 ? 296 SER B C 1 ATOM 4267 O O . SER B 1 230 ? 53.564 82.785 73.383 1.00 36.81 ? 296 SER B O 1 ATOM 4268 C CB . SER B 1 230 ? 55.362 84.182 71.183 1.00 34.47 ? 296 SER B CB 1 ATOM 4269 O OG . SER B 1 230 ? 55.420 84.698 69.869 1.00 42.15 ? 296 SER B OG 1 ATOM 4270 N N . TYR B 1 231 ? 54.670 84.552 74.239 1.00 34.86 ? 297 TYR B N 1 ATOM 4271 C CA . TYR B 1 231 ? 54.904 83.945 75.540 1.00 34.72 ? 297 TYR B CA 1 ATOM 4272 C C . TYR B 1 231 ? 54.314 84.653 76.751 1.00 39.37 ? 297 TYR B C 1 ATOM 4273 O O . TYR B 1 231 ? 53.701 85.716 76.656 1.00 36.71 ? 297 TYR B O 1 ATOM 4274 C CB . TYR B 1 231 ? 56.443 83.829 75.762 1.00 35.61 ? 297 TYR B CB 1 ATOM 4275 C CG . TYR B 1 231 ? 57.243 83.402 74.546 1.00 37.12 ? 297 TYR B CG 1 ATOM 4276 C CD1 . TYR B 1 231 ? 57.232 82.079 74.106 1.00 39.80 ? 297 TYR B CD1 1 ATOM 4277 C CD2 . TYR B 1 231 ? 58.001 84.324 73.828 1.00 37.00 ? 297 TYR B CD2 1 ATOM 4278 C CE1 . TYR B 1 231 ? 57.950 81.687 72.975 1.00 41.33 ? 297 TYR B CE1 1 ATOM 4279 C CE2 . TYR B 1 231 ? 58.746 83.939 72.717 1.00 37.42 ? 297 TYR B CE2 1 ATOM 4280 C CZ . TYR B 1 231 ? 58.711 82.622 72.285 1.00 45.24 ? 297 TYR B CZ 1 ATOM 4281 O OH . TYR B 1 231 ? 59.442 82.253 71.177 1.00 45.71 ? 297 TYR B OH 1 ATOM 4282 N N . ILE B 1 232 ? 54.545 84.036 77.921 1.00 38.32 ? 298 ILE B N 1 ATOM 4283 C CA . ILE B 1 232 ? 54.279 84.672 79.188 1.00 38.48 ? 298 ILE B CA 1 ATOM 4284 C C . ILE B 1 232 ? 55.614 85.371 79.461 1.00 43.65 ? 298 ILE B C 1 ATOM 4285 O O . ILE B 1 232 ? 56.666 84.719 79.485 1.00 43.37 ? 298 ILE B O 1 ATOM 4286 C CB . ILE B 1 232 ? 53.880 83.709 80.334 1.00 40.36 ? 298 ILE B CB 1 ATOM 4287 C CG1 . ILE B 1 232 ? 52.422 83.250 80.169 1.00 38.75 ? 298 ILE B CG1 1 ATOM 4288 C CG2 . ILE B 1 232 ? 54.109 84.396 81.713 1.00 39.99 ? 298 ILE B CG2 1 ATOM 4289 C CD1 . ILE B 1 232 ? 52.093 82.024 80.909 1.00 39.11 ? 298 ILE B CD1 1 ATOM 4290 N N . SER B 1 233 ? 55.577 86.692 79.606 1.00 40.18 ? 299 SER B N 1 ATOM 4291 C CA . SER B 1 233 ? 56.783 87.411 79.911 1.00 39.98 ? 299 SER B CA 1 ATOM 4292 C C . SER B 1 233 ? 56.706 88.144 81.248 1.00 46.06 ? 299 SER B C 1 ATOM 4293 O O . SER B 1 233 ? 55.633 88.543 81.705 1.00 45.33 ? 299 SER B O 1 ATOM 4294 C CB . SER B 1 233 ? 57.178 88.338 78.765 1.00 41.91 ? 299 SER B CB 1 ATOM 4295 O OG . SER B 1 233 ? 56.408 89.526 78.749 1.00 47.54 ? 299 SER B OG 1 ATOM 4296 N N . GLY B 1 234 ? 57.864 88.264 81.868 1.00 43.64 ? 300 GLY B N 1 ATOM 4297 C CA . GLY B 1 234 ? 58.096 89.013 83.087 1.00 43.33 ? 300 GLY B CA 1 ATOM 4298 C C . GLY B 1 234 ? 59.377 89.797 82.888 1.00 49.27 ? 300 GLY B C 1 ATOM 4299 O O . GLY B 1 234 ? 60.074 89.614 81.880 1.00 50.06 ? 300 GLY B O 1 ATOM 4300 N N . SER B 1 235 ? 59.714 90.658 83.851 1.00 45.93 ? 301 SER B N 1 ATOM 4301 C CA . SER B 1 235 ? 60.950 91.450 83.842 1.00 45.15 ? 301 SER B CA 1 ATOM 4302 C C . SER B 1 235 ? 62.135 90.496 84.000 1.00 51.26 ? 301 SER B C 1 ATOM 4303 O O . SER B 1 235 ? 61.956 89.390 84.518 1.00 50.19 ? 301 SER B O 1 ATOM 4304 C CB . SER B 1 235 ? 60.941 92.464 84.983 1.00 44.56 ? 301 SER B CB 1 ATOM 4305 O OG . SER B 1 235 ? 61.070 91.813 86.236 1.00 45.31 ? 301 SER B OG 1 ATOM 4306 N N . THR B 1 236 ? 63.344 90.923 83.563 1.00 50.11 ? 302 THR B N 1 ATOM 4307 C CA . THR B 1 236 ? 64.570 90.120 83.649 1.00 49.54 ? 302 THR B CA 1 ATOM 4308 C C . THR B 1 236 ? 64.786 89.579 85.071 1.00 53.31 ? 302 THR B C 1 ATOM 4309 O O . THR B 1 236 ? 65.061 88.387 85.222 1.00 53.45 ? 302 THR B O 1 ATOM 4310 C CB . THR B 1 236 ? 65.764 90.905 83.092 1.00 57.34 ? 302 THR B CB 1 ATOM 4311 O OG1 . THR B 1 236 ? 65.455 91.284 81.753 1.00 57.95 ? 302 THR B OG1 1 ATOM 4312 C CG2 . THR B 1 236 ? 67.070 90.095 83.101 1.00 55.20 ? 302 THR B CG2 1 ATOM 4313 N N . SER B 1 237 ? 64.608 90.436 86.101 1.00 49.01 ? 303 SER B N 1 ATOM 4314 C CA . SER B 1 237 ? 64.772 90.047 87.501 1.00 48.57 ? 303 SER B CA 1 ATOM 4315 C C . SER B 1 237 ? 63.767 88.976 87.910 1.00 52.21 ? 303 SER B C 1 ATOM 4316 O O . SER B 1 237 ? 64.188 87.921 88.392 1.00 52.92 ? 303 SER B O 1 ATOM 4317 C CB . SER B 1 237 ? 64.729 91.257 88.433 1.00 53.15 ? 303 SER B CB 1 ATOM 4318 O OG . SER B 1 237 ? 63.663 92.139 88.124 1.00 68.57 ? 303 SER B OG 1 ATOM 4319 N N . SER B 1 238 ? 62.455 89.205 87.649 1.00 47.03 ? 304 SER B N 1 ATOM 4320 C CA . SER B 1 238 ? 61.374 88.253 87.950 1.00 45.98 ? 304 SER B CA 1 ATOM 4321 C C . SER B 1 238 ? 61.629 86.895 87.285 1.00 48.25 ? 304 SER B C 1 ATOM 4322 O O . SER B 1 238 ? 61.530 85.855 87.940 1.00 47.41 ? 304 SER B O 1 ATOM 4323 C CB . SER B 1 238 ? 60.024 88.800 87.493 1.00 47.71 ? 304 SER B CB 1 ATOM 4324 O OG . SER B 1 238 ? 59.723 90.047 88.095 1.00 52.12 ? 304 SER B OG 1 ATOM 4325 N N . ILE B 1 239 ? 62.006 86.918 85.998 1.00 44.05 ? 305 ILE B N 1 ATOM 4326 C CA . ILE B 1 239 ? 62.269 85.712 85.218 1.00 43.72 ? 305 ILE B CA 1 ATOM 4327 C C . ILE B 1 239 ? 63.542 85.015 85.717 1.00 48.87 ? 305 ILE B C 1 ATOM 4328 O O . ILE B 1 239 ? 63.561 83.787 85.744 1.00 49.37 ? 305 ILE B O 1 ATOM 4329 C CB . ILE B 1 239 ? 62.219 86.000 83.686 1.00 46.45 ? 305 ILE B CB 1 ATOM 4330 C CG1 . ILE B 1 239 ? 60.798 86.474 83.252 1.00 46.06 ? 305 ILE B CG1 1 ATOM 4331 C CG2 . ILE B 1 239 ? 62.706 84.808 82.835 1.00 47.20 ? 305 ILE B CG2 1 ATOM 4332 C CD1 . ILE B 1 239 ? 59.573 85.585 83.664 1.00 43.61 ? 305 ILE B CD1 1 ATOM 4333 N N . GLU B 1 240 ? 64.543 85.770 86.215 1.00 46.75 ? 306 GLU B N 1 ATOM 4334 C CA . GLU B 1 240 ? 65.744 85.164 86.803 1.00 47.18 ? 306 GLU B CA 1 ATOM 4335 C C . GLU B 1 240 ? 65.401 84.343 88.064 1.00 50.28 ? 306 GLU B C 1 ATOM 4336 O O . GLU B 1 240 ? 65.841 83.195 88.172 1.00 49.22 ? 306 GLU B O 1 ATOM 4337 C CB . GLU B 1 240 ? 66.837 86.207 87.075 1.00 48.85 ? 306 GLU B CB 1 ATOM 4338 C CG . GLU B 1 240 ? 67.715 86.456 85.856 1.00 60.66 ? 306 GLU B CG 1 ATOM 4339 C CD . GLU B 1 240 ? 68.505 87.753 85.810 1.00 84.81 ? 306 GLU B CD 1 ATOM 4340 O OE1 . GLU B 1 240 ? 68.417 88.555 86.770 1.00 76.08 ? 306 GLU B OE1 1 ATOM 4341 O OE2 . GLU B 1 240 ? 69.216 87.966 84.800 1.00 78.81 ? 306 GLU B OE2 1 ATOM 4342 N N . LYS B 1 241 ? 64.555 84.896 88.970 1.00 47.99 ? 307 LYS B N 1 ATOM 4343 C CA . LYS B 1 241 ? 64.126 84.193 90.188 1.00 48.21 ? 307 LYS B CA 1 ATOM 4344 C C . LYS B 1 241 ? 63.260 83.003 89.825 1.00 53.15 ? 307 LYS B C 1 ATOM 4345 O O . LYS B 1 241 ? 63.496 81.920 90.352 1.00 54.69 ? 307 LYS B O 1 ATOM 4346 C CB . LYS B 1 241 ? 63.365 85.101 91.163 1.00 51.96 ? 307 LYS B CB 1 ATOM 4347 C CG . LYS B 1 241 ? 64.021 86.442 91.476 1.00 68.38 ? 307 LYS B CG 1 ATOM 4348 C CD . LYS B 1 241 ? 63.131 87.207 92.461 1.00 78.18 ? 307 LYS B CD 1 ATOM 4349 C CE . LYS B 1 241 ? 63.497 88.651 92.680 1.00 80.88 ? 307 LYS B CE 1 ATOM 4350 N NZ . LYS B 1 241 ? 62.902 89.527 91.622 1.00 81.33 ? 307 LYS B NZ 1 ATOM 4351 N N . LEU B 1 242 ? 62.275 83.188 88.910 1.00 48.93 ? 308 LEU B N 1 ATOM 4352 C CA . LEU B 1 242 ? 61.384 82.117 88.444 1.00 48.25 ? 308 LEU B CA 1 ATOM 4353 C C . LEU B 1 242 ? 62.185 80.956 87.848 1.00 47.67 ? 308 LEU B C 1 ATOM 4354 O O . LEU B 1 242 ? 61.928 79.805 88.194 1.00 47.49 ? 308 LEU B O 1 ATOM 4355 C CB . LEU B 1 242 ? 60.346 82.655 87.432 1.00 48.80 ? 308 LEU B CB 1 ATOM 4356 C CG . LEU B 1 242 ? 59.506 81.634 86.654 1.00 54.39 ? 308 LEU B CG 1 ATOM 4357 C CD1 . LEU B 1 242 ? 58.224 81.311 87.376 1.00 55.77 ? 308 LEU B CD1 1 ATOM 4358 C CD2 . LEU B 1 242 ? 59.184 82.155 85.293 1.00 57.24 ? 308 LEU B CD2 1 ATOM 4359 N N . MET B 1 243 ? 63.164 81.256 86.993 1.00 42.12 ? 309 MET B N 1 ATOM 4360 C CA . MET B 1 243 ? 63.969 80.212 86.351 1.00 41.77 ? 309 MET B CA 1 ATOM 4361 C C . MET B 1 243 ? 64.902 79.473 87.314 1.00 49.71 ? 309 MET B C 1 ATOM 4362 O O . MET B 1 243 ? 65.109 78.267 87.155 1.00 49.60 ? 309 MET B O 1 ATOM 4363 C CB . MET B 1 243 ? 64.725 80.772 85.142 1.00 43.07 ? 309 MET B CB 1 ATOM 4364 C CG . MET B 1 243 ? 63.802 81.172 83.998 1.00 45.13 ? 309 MET B CG 1 ATOM 4365 S SD . MET B 1 243 ? 62.905 79.790 83.293 1.00 47.65 ? 309 MET B SD 1 ATOM 4366 C CE . MET B 1 243 ? 61.880 80.682 82.119 1.00 44.47 ? 309 MET B CE 1 ATOM 4367 N N . GLU B 1 244 ? 65.431 80.185 88.328 1.00 48.96 ? 310 GLU B N 1 ATOM 4368 C CA . GLU B 1 244 ? 66.267 79.604 89.375 1.00 49.42 ? 310 GLU B CA 1 ATOM 4369 C C . GLU B 1 244 ? 65.434 78.535 90.115 1.00 51.42 ? 310 GLU B C 1 ATOM 4370 O O . GLU B 1 244 ? 65.904 77.411 90.294 1.00 51.90 ? 310 GLU B O 1 ATOM 4371 C CB . GLU B 1 244 ? 66.755 80.704 90.331 1.00 51.36 ? 310 GLU B CB 1 ATOM 4372 C CG . GLU B 1 244 ? 67.766 80.224 91.365 1.00 68.66 ? 310 GLU B CG 1 ATOM 4373 C CD . GLU B 1 244 ? 67.957 81.124 92.575 1.00 107.25 ? 310 GLU B CD 1 ATOM 4374 O OE1 . GLU B 1 244 ? 67.027 81.895 92.910 1.00 105.58 ? 310 GLU B OE1 1 ATOM 4375 O OE2 . GLU B 1 244 ? 69.027 81.022 93.219 1.00 109.64 ? 310 GLU B OE2 1 ATOM 4376 N N . ALA B 1 245 ? 64.176 78.874 90.456 1.00 45.96 ? 311 ALA B N 1 ATOM 4377 C CA . ALA B 1 245 ? 63.197 78.010 91.120 1.00 45.26 ? 311 ALA B CA 1 ATOM 4378 C C . ALA B 1 245 ? 62.838 76.745 90.314 1.00 50.20 ? 311 ALA B C 1 ATOM 4379 O O . ALA B 1 245 ? 62.571 75.688 90.904 1.00 49.92 ? 311 ALA B O 1 ATOM 4380 C CB . ALA B 1 245 ? 61.943 78.804 91.434 1.00 45.71 ? 311 ALA B CB 1 ATOM 4381 N N . LEU B 1 246 ? 62.826 76.845 88.970 1.00 47.37 ? 312 LEU B N 1 ATOM 4382 C CA . LEU B 1 246 ? 62.528 75.700 88.092 1.00 46.10 ? 312 LEU B CA 1 ATOM 4383 C C . LEU B 1 246 ? 63.777 74.840 87.803 1.00 51.94 ? 312 LEU B C 1 ATOM 4384 O O . LEU B 1 246 ? 63.645 73.698 87.359 1.00 51.99 ? 312 LEU B O 1 ATOM 4385 C CB . LEU B 1 246 ? 61.878 76.157 86.767 1.00 45.09 ? 312 LEU B CB 1 ATOM 4386 C CG . LEU B 1 246 ? 60.610 77.001 86.868 1.00 47.78 ? 312 LEU B CG 1 ATOM 4387 C CD1 . LEU B 1 246 ? 60.309 77.691 85.521 1.00 47.08 ? 312 LEU B CD1 1 ATOM 4388 C CD2 . LEU B 1 246 ? 59.425 76.158 87.330 1.00 47.79 ? 312 LEU B CD2 1 ATOM 4389 N N . GLY B 1 247 ? 64.969 75.389 88.063 1.00 48.86 ? 313 GLY B N 1 ATOM 4390 C CA . GLY B 1 247 ? 66.225 74.702 87.792 1.00 48.66 ? 313 GLY B CA 1 ATOM 4391 C C . GLY B 1 247 ? 66.579 74.769 86.318 1.00 53.72 ? 313 GLY B C 1 ATOM 4392 O O . GLY B 1 247 ? 67.308 73.913 85.814 1.00 54.13 ? 313 GLY B O 1 ATOM 4393 N N . ALA B 1 248 ? 66.058 75.801 85.621 1.00 50.64 ? 314 ALA B N 1 ATOM 4394 C CA . ALA B 1 248 ? 66.307 76.069 84.208 1.00 50.55 ? 314 ALA B CA 1 ATOM 4395 C C . ALA B 1 248 ? 67.589 76.879 84.050 1.00 56.73 ? 314 ALA B C 1 ATOM 4396 O O . ALA B 1 248 ? 67.881 77.759 84.863 1.00 57.58 ? 314 ALA B O 1 ATOM 4397 C CB . ALA B 1 248 ? 65.135 76.813 83.583 1.00 50.70 ? 314 ALA B CB 1 ATOM 4398 N N . LYS B 1 249 ? 68.356 76.571 83.004 1.00 52.57 ? 315 LYS B N 1 ATOM 4399 C CA . LYS B 1 249 ? 69.618 77.235 82.723 1.00 51.98 ? 315 LYS B CA 1 ATOM 4400 C C . LYS B 1 249 ? 69.508 78.086 81.472 1.00 55.41 ? 315 LYS B C 1 ATOM 4401 O O . LYS B 1 249 ? 68.832 77.688 80.527 1.00 53.98 ? 315 LYS B O 1 ATOM 4402 C CB . LYS B 1 249 ? 70.722 76.172 82.539 1.00 54.31 ? 315 LYS B CB 1 ATOM 4403 N N . LYS B 1 250 ? 70.204 79.227 81.430 1.00 52.99 ? 316 LYS B N 1 ATOM 4404 C CA . LYS B 1 250 ? 70.255 80.022 80.210 1.00 53.60 ? 316 LYS B CA 1 ATOM 4405 C C . LYS B 1 250 ? 71.308 79.352 79.309 1.00 61.39 ? 316 LYS B C 1 ATOM 4406 O O . LYS B 1 250 ? 72.462 79.206 79.724 1.00 62.48 ? 316 LYS B O 1 ATOM 4407 C CB . LYS B 1 250 ? 70.644 81.477 80.489 1.00 55.07 ? 316 LYS B CB 1 ATOM 4408 C CG . LYS B 1 250 ? 70.392 82.388 79.297 1.00 63.77 ? 316 LYS B CG 1 ATOM 4409 C CD . LYS B 1 250 ? 69.303 83.395 79.590 1.00 72.01 ? 316 LYS B CD 1 ATOM 4410 C CE . LYS B 1 250 ? 69.069 84.328 78.428 1.00 85.67 ? 316 LYS B CE 1 ATOM 4411 N NZ . LYS B 1 250 ? 68.135 85.435 78.785 1.00 96.65 ? 316 LYS B NZ 1 ATOM 4412 N N . ARG B 1 251 ? 70.890 78.893 78.112 1.00 59.14 ? 317 ARG B N 1 ATOM 4413 C CA . ARG B 1 251 ? 71.726 78.249 77.091 1.00 59.26 ? 317 ARG B CA 1 ATOM 4414 C C . ARG B 1 251 ? 72.659 79.363 76.550 1.00 64.57 ? 317 ARG B C 1 ATOM 4415 O O . ARG B 1 251 ? 73.664 79.729 77.192 1.00 64.01 ? 317 ARG B O 1 ATOM 4416 C CB . ARG B 1 251 ? 70.805 77.701 75.970 1.00 57.13 ? 317 ARG B CB 1 ATOM 4417 C CG . ARG B 1 251 ? 71.191 76.375 75.298 1.00 56.15 ? 317 ARG B CG 1 ATOM 4418 C CD . ARG B 1 251 ? 70.347 76.213 74.033 1.00 53.79 ? 317 ARG B CD 1 ATOM 4419 N NE . ARG B 1 251 ? 69.856 74.853 73.791 1.00 57.72 ? 317 ARG B NE 1 ATOM 4420 C CZ . ARG B 1 251 ? 68.740 74.556 73.123 1.00 74.23 ? 317 ARG B CZ 1 ATOM 4421 N NH1 . ARG B 1 251 ? 67.973 75.520 72.628 1.00 58.21 ? 317 ARG B NH1 1 ATOM 4422 N NH2 . ARG B 1 251 ? 68.377 73.292 72.956 1.00 71.86 ? 317 ARG B NH2 1 ATOM 4423 N N . LEU B 1 252 ? 72.273 79.938 75.411 1.00 61.40 ? 318 LEU B N 1 ATOM 4424 C CA . LEU B 1 252 ? 72.975 81.036 74.775 1.00 61.19 ? 318 LEU B CA 1 ATOM 4425 C C . LEU B 1 252 ? 71.965 82.153 74.615 1.00 64.14 ? 318 LEU B C 1 ATOM 4426 O O . LEU B 1 252 ? 72.191 83.267 75.088 1.00 64.68 ? 318 LEU B O 1 ATOM 4427 C CB . LEU B 1 252 ? 73.566 80.604 73.415 1.00 61.48 ? 318 LEU B CB 1 ATOM 4428 C CG . LEU B 1 252 ? 74.745 79.608 73.479 1.00 66.38 ? 318 LEU B CG 1 ATOM 4429 C CD1 . LEU B 1 252 ? 74.836 78.801 72.220 1.00 67.12 ? 318 LEU B CD1 1 ATOM 4430 C CD2 . LEU B 1 252 ? 76.065 80.308 73.736 1.00 67.32 ? 318 LEU B CD2 1 ATOM 4431 N N . PHE B 1 253 ? 70.809 81.824 74.037 1.00 59.41 ? 319 PHE B N 1 ATOM 4432 C CA . PHE B 1 253 ? 69.726 82.770 73.801 1.00 57.81 ? 319 PHE B CA 1 ATOM 4433 C C . PHE B 1 253 ? 68.583 82.575 74.796 1.00 61.00 ? 319 PHE B C 1 ATOM 4434 O O . PHE B 1 253 ? 68.027 83.576 75.267 1.00 62.00 ? 319 PHE B O 1 ATOM 4435 C CB . PHE B 1 253 ? 69.216 82.660 72.340 1.00 58.60 ? 319 PHE B CB 1 ATOM 4436 C CG . PHE B 1 253 ? 70.294 82.716 71.270 1.00 58.91 ? 319 PHE B CG 1 ATOM 4437 C CD1 . PHE B 1 253 ? 70.937 81.556 70.843 1.00 60.69 ? 319 PHE B CD1 1 ATOM 4438 C CD2 . PHE B 1 253 ? 70.669 83.927 70.697 1.00 59.84 ? 319 PHE B CD2 1 ATOM 4439 C CE1 . PHE B 1 253 ? 71.940 81.606 69.864 1.00 61.11 ? 319 PHE B CE1 1 ATOM 4440 C CE2 . PHE B 1 253 ? 71.684 83.978 69.727 1.00 62.65 ? 319 PHE B CE2 1 ATOM 4441 C CZ . PHE B 1 253 ? 72.309 82.818 69.313 1.00 60.56 ? 319 PHE B CZ 1 ATOM 4442 N N . ASP B 1 254 ? 68.243 81.299 75.136 1.00 54.32 ? 320 ASP B N 1 ATOM 4443 C CA . ASP B 1 254 ? 67.077 80.996 75.978 1.00 52.91 ? 320 ASP B CA 1 ATOM 4444 C C . ASP B 1 254 ? 67.304 80.137 77.224 1.00 52.70 ? 320 ASP B C 1 ATOM 4445 O O . ASP B 1 254 ? 68.367 79.545 77.381 1.00 52.54 ? 320 ASP B O 1 ATOM 4446 C CB . ASP B 1 254 ? 66.003 80.310 75.115 1.00 54.92 ? 320 ASP B CB 1 ATOM 4447 C CG . ASP B 1 254 ? 65.542 81.124 73.929 1.00 70.23 ? 320 ASP B CG 1 ATOM 4448 O OD1 . ASP B 1 254 ? 65.133 82.289 74.131 1.00 72.86 ? 320 ASP B OD1 1 ATOM 4449 O OD2 . ASP B 1 254 ? 65.613 80.607 72.795 1.00 75.82 ? 320 ASP B OD2 1 ATOM 4450 N N . TYR B 1 255 ? 66.262 80.040 78.081 1.00 45.22 ? 321 TYR B N 1 ATOM 4451 C CA . TYR B 1 255 ? 66.234 79.187 79.256 1.00 43.96 ? 321 TYR B CA 1 ATOM 4452 C C . TYR B 1 255 ? 65.726 77.813 78.813 1.00 49.37 ? 321 TYR B C 1 ATOM 4453 O O . TYR B 1 255 ? 64.746 77.715 78.060 1.00 51.34 ? 321 TYR B O 1 ATOM 4454 C CB . TYR B 1 255 ? 65.336 79.751 80.372 1.00 43.92 ? 321 TYR B CB 1 ATOM 4455 C CG . TYR B 1 255 ? 65.874 80.973 81.088 1.00 44.94 ? 321 TYR B CG 1 ATOM 4456 C CD1 . TYR B 1 255 ? 66.803 80.853 82.122 1.00 46.31 ? 321 TYR B CD1 1 ATOM 4457 C CD2 . TYR B 1 255 ? 65.414 82.247 80.770 1.00 45.95 ? 321 TYR B CD2 1 ATOM 4458 C CE1 . TYR B 1 255 ? 67.263 81.976 82.816 1.00 45.97 ? 321 TYR B CE1 1 ATOM 4459 C CE2 . TYR B 1 255 ? 65.869 83.374 81.452 1.00 46.86 ? 321 TYR B CE2 1 ATOM 4460 C CZ . TYR B 1 255 ? 66.783 83.234 82.484 1.00 54.69 ? 321 TYR B CZ 1 ATOM 4461 O OH . TYR B 1 255 ? 67.230 84.368 83.128 1.00 57.85 ? 321 TYR B OH 1 ATOM 4462 N N . VAL B 1 256 ? 66.413 76.754 79.254 1.00 44.38 ? 322 VAL B N 1 ATOM 4463 C CA . VAL B 1 256 ? 66.121 75.352 78.928 1.00 43.90 ? 322 VAL B CA 1 ATOM 4464 C C . VAL B 1 256 ? 66.191 74.454 80.168 1.00 45.23 ? 322 VAL B C 1 ATOM 4465 O O . VAL B 1 256 ? 66.799 74.827 81.178 1.00 43.49 ? 322 VAL B O 1 ATOM 4466 C CB . VAL B 1 256 ? 67.073 74.804 77.808 1.00 47.42 ? 322 VAL B CB 1 ATOM 4467 C CG1 . VAL B 1 256 ? 66.781 75.453 76.457 1.00 47.32 ? 322 VAL B CG1 1 ATOM 4468 C CG2 . VAL B 1 256 ? 68.552 74.951 78.195 1.00 47.05 ? 322 VAL B CG2 1 ATOM 4469 N N . VAL B 1 257 ? 65.594 73.253 80.050 1.00 40.67 ? 323 VAL B N 1 ATOM 4470 C CA . VAL B 1 257 ? 65.656 72.164 81.033 1.00 40.57 ? 323 VAL B CA 1 ATOM 4471 C C . VAL B 1 257 ? 65.950 70.891 80.236 1.00 44.41 ? 323 VAL B C 1 ATOM 4472 O O . VAL B 1 257 ? 65.659 70.865 79.038 1.00 44.05 ? 323 VAL B O 1 ATOM 4473 C CB . VAL B 1 257 ? 64.379 71.988 81.921 1.00 44.62 ? 323 VAL B CB 1 ATOM 4474 C CG1 . VAL B 1 257 ? 64.167 73.173 82.864 1.00 44.45 ? 323 VAL B CG1 1 ATOM 4475 C CG2 . VAL B 1 257 ? 63.134 71.725 81.081 1.00 44.67 ? 323 VAL B CG2 1 ATOM 4476 N N . LYS B 1 258 ? 66.476 69.830 80.884 1.00 41.05 ? 324 LYS B N 1 ATOM 4477 C CA . LYS B 1 258 ? 66.659 68.528 80.224 1.00 41.61 ? 324 LYS B CA 1 ATOM 4478 C C . LYS B 1 258 ? 65.240 68.067 79.911 1.00 46.59 ? 324 LYS B C 1 ATOM 4479 O O . LYS B 1 258 ? 64.380 68.178 80.785 1.00 46.55 ? 324 LYS B O 1 ATOM 4480 C CB . LYS B 1 258 ? 67.350 67.507 81.147 1.00 44.17 ? 324 LYS B CB 1 ATOM 4481 C CG . LYS B 1 258 ? 68.841 67.750 81.365 1.00 54.11 ? 324 LYS B CG 1 ATOM 4482 C CD . LYS B 1 258 ? 69.609 66.415 81.410 1.00 69.55 ? 324 LYS B CD 1 ATOM 4483 C CE . LYS B 1 258 ? 69.659 65.709 82.753 1.00 75.06 ? 324 LYS B CE 1 ATOM 4484 N NZ . LYS B 1 258 ? 69.910 64.246 82.622 1.00 80.66 ? 324 LYS B NZ 1 ATOM 4485 N N . CYS B 1 259 ? 64.969 67.629 78.659 1.00 43.44 ? 325 CYS B N 1 ATOM 4486 C CA . CYS B 1 259 ? 63.611 67.271 78.209 1.00 43.21 ? 325 CYS B CA 1 ATOM 4487 C C . CYS B 1 259 ? 62.862 66.301 79.137 1.00 45.85 ? 325 CYS B C 1 ATOM 4488 O O . CYS B 1 259 ? 61.656 66.498 79.385 1.00 44.29 ? 325 CYS B O 1 ATOM 4489 C CB . CYS B 1 259 ? 63.617 66.777 76.770 1.00 43.94 ? 325 CYS B CB 1 ATOM 4490 S SG . CYS B 1 259 ? 63.995 68.077 75.566 1.00 48.32 ? 325 CYS B SG 1 ATOM 4491 N N . ASN B 1 260 ? 63.583 65.294 79.690 1.00 40.89 ? 326 ASN B N 1 ATOM 4492 C CA . ASN B 1 260 ? 62.991 64.306 80.595 1.00 40.04 ? 326 ASN B CA 1 ATOM 4493 C C . ASN B 1 260 ? 62.572 64.934 81.906 1.00 42.80 ? 326 ASN B C 1 ATOM 4494 O O . ASN B 1 260 ? 61.667 64.419 82.539 1.00 42.52 ? 326 ASN B O 1 ATOM 4495 C CB . ASN B 1 260 ? 63.959 63.151 80.858 1.00 40.99 ? 326 ASN B CB 1 ATOM 4496 C CG . ASN B 1 260 ? 65.228 63.562 81.577 1.00 51.63 ? 326 ASN B CG 1 ATOM 4497 O OD1 . ASN B 1 260 ? 65.939 64.495 81.178 1.00 39.12 ? 326 ASN B OD1 1 ATOM 4498 N ND2 . ASN B 1 260 ? 65.532 62.872 82.657 1.00 42.39 ? 326 ASN B ND2 1 ATOM 4499 N N . GLU B 1 261 ? 63.240 66.015 82.327 1.00 38.81 ? 327 GLU B N 1 ATOM 4500 C CA . GLU B 1 261 ? 62.927 66.715 83.566 1.00 39.21 ? 327 GLU B CA 1 ATOM 4501 C C . GLU B 1 261 ? 61.676 67.583 83.471 1.00 45.47 ? 327 GLU B C 1 ATOM 4502 O O . GLU B 1 261 ? 61.093 67.889 84.507 1.00 45.80 ? 327 GLU B O 1 ATOM 4503 C CB . GLU B 1 261 ? 64.134 67.517 84.060 1.00 40.60 ? 327 GLU B CB 1 ATOM 4504 C CG . GLU B 1 261 ? 65.153 66.645 84.786 1.00 49.66 ? 327 GLU B CG 1 ATOM 4505 C CD . GLU B 1 261 ? 66.514 67.265 85.033 1.00 75.16 ? 327 GLU B CD 1 ATOM 4506 O OE1 . GLU B 1 261 ? 67.470 66.485 85.223 1.00 77.94 ? 327 GLU B OE1 1 ATOM 4507 O OE2 . GLU B 1 261 ? 66.637 68.513 85.018 1.00 83.24 ? 327 GLU B OE2 1 ATOM 4508 N N . GLY B 1 262 ? 61.242 67.924 82.255 1.00 42.53 ? 328 GLY B N 1 ATOM 4509 C CA . GLY B 1 262 ? 60.041 68.722 82.018 1.00 42.30 ? 328 GLY B CA 1 ATOM 4510 C C . GLY B 1 262 ? 58.831 68.315 82.846 1.00 46.62 ? 328 GLY B C 1 ATOM 4511 O O . GLY B 1 262 ? 58.391 69.117 83.677 1.00 45.73 ? 328 GLY B O 1 ATOM 4512 N N . PRO B 1 263 ? 58.340 67.045 82.734 1.00 43.36 ? 329 PRO B N 1 ATOM 4513 C CA . PRO B 1 263 ? 57.158 66.621 83.533 1.00 43.29 ? 329 PRO B CA 1 ATOM 4514 C C . PRO B 1 263 ? 57.320 66.637 85.064 1.00 48.19 ? 329 PRO B C 1 ATOM 4515 O O . PRO B 1 263 ? 56.357 66.377 85.779 1.00 47.96 ? 329 PRO B O 1 ATOM 4516 C CB . PRO B 1 263 ? 56.854 65.199 83.001 1.00 44.69 ? 329 PRO B CB 1 ATOM 4517 C CG . PRO B 1 263 ? 57.538 65.149 81.649 1.00 48.51 ? 329 PRO B CG 1 ATOM 4518 C CD . PRO B 1 263 ? 58.774 65.969 81.813 1.00 44.11 ? 329 PRO B CD 1 ATOM 4519 N N . THR B 1 264 ? 58.530 66.941 85.566 1.00 45.87 ? 330 THR B N 1 ATOM 4520 C CA . THR B 1 264 ? 58.828 67.028 87.008 1.00 45.42 ? 330 THR B CA 1 ATOM 4521 C C . THR B 1 264 ? 58.803 68.475 87.509 1.00 46.91 ? 330 THR B C 1 ATOM 4522 O O . THR B 1 264 ? 58.969 68.699 88.708 1.00 47.10 ? 330 THR B O 1 ATOM 4523 C CB . THR B 1 264 ? 60.201 66.379 87.359 1.00 52.63 ? 330 THR B CB 1 ATOM 4524 O OG1 . THR B 1 264 ? 61.275 67.262 87.035 1.00 48.28 ? 330 THR B OG1 1 ATOM 4525 C CG2 . THR B 1 264 ? 60.408 65.046 86.704 1.00 53.99 ? 330 THR B CG2 1 ATOM 4526 N N . LEU B 1 265 ? 58.686 69.457 86.598 1.00 41.54 ? 331 LEU B N 1 ATOM 4527 C CA . LEU B 1 265 ? 58.679 70.872 86.973 1.00 40.03 ? 331 LEU B CA 1 ATOM 4528 C C . LEU B 1 265 ? 57.374 71.254 87.666 1.00 43.37 ? 331 LEU B C 1 ATOM 4529 O O . LEU B 1 265 ? 56.326 70.670 87.363 1.00 42.11 ? 331 LEU B O 1 ATOM 4530 C CB . LEU B 1 265 ? 58.965 71.787 85.785 1.00 39.66 ? 331 LEU B CB 1 ATOM 4531 C CG . LEU B 1 265 ? 60.317 71.656 85.108 1.00 44.14 ? 331 LEU B CG 1 ATOM 4532 C CD1 . LEU B 1 265 ? 60.614 72.897 84.298 1.00 44.36 ? 331 LEU B CD1 1 ATOM 4533 C CD2 . LEU B 1 265 ? 61.437 71.423 86.107 1.00 45.44 ? 331 LEU B CD2 1 ATOM 4534 N N . PRO B 1 266 ? 57.409 72.193 88.641 1.00 40.77 ? 332 PRO B N 1 ATOM 4535 C CA . PRO B 1 266 ? 56.164 72.520 89.363 1.00 40.75 ? 332 PRO B CA 1 ATOM 4536 C C . PRO B 1 266 ? 55.166 73.323 88.539 1.00 45.94 ? 332 PRO B C 1 ATOM 4537 O O . PRO B 1 266 ? 55.489 73.815 87.453 1.00 45.54 ? 332 PRO B O 1 ATOM 4538 C CB . PRO B 1 266 ? 56.660 73.322 90.576 1.00 41.88 ? 332 PRO B CB 1 ATOM 4539 C CG . PRO B 1 266 ? 57.929 73.983 90.084 1.00 46.06 ? 332 PRO B CG 1 ATOM 4540 C CD . PRO B 1 266 ? 58.561 72.967 89.167 1.00 41.77 ? 332 PRO B CD 1 ATOM 4541 N N . ASP B 1 267 ? 53.950 73.474 89.088 1.00 42.58 ? 333 ASP B N 1 ATOM 4542 C CA . ASP B 1 267 ? 52.890 74.282 88.505 1.00 40.98 ? 333 ASP B CA 1 ATOM 4543 C C . ASP B 1 267 ? 53.237 75.735 88.754 1.00 42.94 ? 333 ASP B C 1 ATOM 4544 O O . ASP B 1 267 ? 53.892 76.048 89.750 1.00 43.68 ? 333 ASP B O 1 ATOM 4545 C CB . ASP B 1 267 ? 51.551 73.990 89.202 1.00 42.37 ? 333 ASP B CB 1 ATOM 4546 C CG . ASP B 1 267 ? 50.939 72.624 88.962 1.00 48.23 ? 333 ASP B CG 1 ATOM 4547 O OD1 . ASP B 1 267 ? 51.512 71.843 88.160 1.00 49.65 ? 333 ASP B OD1 1 ATOM 4548 O OD2 . ASP B 1 267 ? 49.857 72.350 89.539 1.00 46.71 ? 333 ASP B OD2 1 ATOM 4549 N N . ILE B 1 268 ? 52.824 76.619 87.839 1.00 37.20 ? 334 ILE B N 1 ATOM 4550 C CA . ILE B 1 268 ? 52.982 78.058 87.977 1.00 36.46 ? 334 ILE B CA 1 ATOM 4551 C C . ILE B 1 268 ? 51.558 78.608 87.987 1.00 40.64 ? 334 ILE B C 1 ATOM 4552 O O . ILE B 1 268 ? 50.765 78.273 87.104 1.00 39.67 ? 334 ILE B O 1 ATOM 4553 C CB . ILE B 1 268 ? 53.910 78.734 86.923 1.00 38.93 ? 334 ILE B CB 1 ATOM 4554 C CG1 . ILE B 1 268 ? 55.296 78.061 86.902 1.00 38.63 ? 334 ILE B CG1 1 ATOM 4555 C CG2 . ILE B 1 268 ? 54.042 80.250 87.188 1.00 39.72 ? 334 ILE B CG2 1 ATOM 4556 C CD1 . ILE B 1 268 ? 56.215 78.470 85.756 1.00 34.63 ? 334 ILE B CD1 1 ATOM 4557 N N . SER B 1 269 ? 51.235 79.404 89.020 1.00 37.35 ? 335 SER B N 1 ATOM 4558 C CA . SER B 1 269 ? 49.924 79.996 89.238 1.00 36.98 ? 335 SER B CA 1 ATOM 4559 C C . SER B 1 269 ? 50.009 81.512 89.240 1.00 38.95 ? 335 SER B C 1 ATOM 4560 O O . SER B 1 269 ? 50.906 82.081 89.858 1.00 39.01 ? 335 SER B O 1 ATOM 4561 C CB . SER B 1 269 ? 49.331 79.503 90.560 1.00 39.83 ? 335 SER B CB 1 ATOM 4562 O OG . SER B 1 269 ? 49.209 78.092 90.597 1.00 51.02 ? 335 SER B OG 1 ATOM 4563 N N . PHE B 1 270 ? 49.080 82.152 88.545 1.00 34.07 ? 336 PHE B N 1 ATOM 4564 C CA . PHE B 1 270 ? 48.974 83.601 88.451 1.00 35.15 ? 336 PHE B CA 1 ATOM 4565 C C . PHE B 1 270 ? 47.660 83.995 89.147 1.00 41.80 ? 336 PHE B C 1 ATOM 4566 O O . PHE B 1 270 ? 46.581 83.546 88.737 1.00 40.42 ? 336 PHE B O 1 ATOM 4567 C CB . PHE B 1 270 ? 49.011 84.084 86.972 1.00 36.30 ? 336 PHE B CB 1 ATOM 4568 C CG . PHE B 1 270 ? 50.186 83.564 86.172 1.00 37.42 ? 336 PHE B CG 1 ATOM 4569 C CD1 . PHE B 1 270 ? 50.111 82.341 85.513 1.00 40.27 ? 336 PHE B CD1 1 ATOM 4570 C CD2 . PHE B 1 270 ? 51.373 84.290 86.086 1.00 39.02 ? 336 PHE B CD2 1 ATOM 4571 C CE1 . PHE B 1 270 ? 51.203 81.848 84.796 1.00 41.20 ? 336 PHE B CE1 1 ATOM 4572 C CE2 . PHE B 1 270 ? 52.473 83.788 85.380 1.00 41.25 ? 336 PHE B CE2 1 ATOM 4573 C CZ . PHE B 1 270 ? 52.379 82.574 84.735 1.00 39.79 ? 336 PHE B CZ 1 ATOM 4574 N N . HIS B 1 271 ? 47.768 84.778 90.229 1.00 41.51 ? 337 HIS B N 1 ATOM 4575 C CA . HIS B 1 271 ? 46.619 85.223 91.012 1.00 42.98 ? 337 HIS B CA 1 ATOM 4576 C C . HIS B 1 271 ? 46.030 86.476 90.370 1.00 41.71 ? 337 HIS B C 1 ATOM 4577 O O . HIS B 1 271 ? 46.646 87.542 90.369 1.00 41.19 ? 337 HIS B O 1 ATOM 4578 C CB . HIS B 1 271 ? 47.007 85.454 92.481 1.00 46.30 ? 337 HIS B CB 1 ATOM 4579 C CG . HIS B 1 271 ? 45.836 85.488 93.437 1.00 52.22 ? 337 HIS B CG 1 ATOM 4580 N ND1 . HIS B 1 271 ? 46.000 85.191 94.782 1.00 55.46 ? 337 HIS B ND1 1 ATOM 4581 C CD2 . HIS B 1 271 ? 44.528 85.778 93.219 1.00 55.24 ? 337 HIS B CD2 1 ATOM 4582 C CE1 . HIS B 1 271 ? 44.795 85.303 95.329 1.00 55.20 ? 337 HIS B CE1 1 ATOM 4583 N NE2 . HIS B 1 271 ? 43.883 85.655 94.430 1.00 55.36 ? 337 HIS B NE2 1 ATOM 4584 N N . LEU B 1 272 ? 44.839 86.323 89.808 1.00 35.92 ? 338 LEU B N 1 ATOM 4585 C CA . LEU B 1 272 ? 44.125 87.367 89.093 1.00 35.62 ? 338 LEU B CA 1 ATOM 4586 C C . LEU B 1 272 ? 42.669 87.401 89.562 1.00 39.61 ? 338 LEU B C 1 ATOM 4587 O O . LEU B 1 272 ? 41.974 86.385 89.497 1.00 37.02 ? 338 LEU B O 1 ATOM 4588 C CB . LEU B 1 272 ? 44.212 87.133 87.557 1.00 35.13 ? 338 LEU B CB 1 ATOM 4589 C CG . LEU B 1 272 ? 45.630 86.902 86.937 1.00 38.20 ? 338 LEU B CG 1 ATOM 4590 C CD1 . LEU B 1 272 ? 45.540 86.240 85.561 1.00 37.31 ? 338 LEU B CD1 1 ATOM 4591 C CD2 . LEU B 1 272 ? 46.408 88.196 86.827 1.00 38.87 ? 338 LEU B CD2 1 ATOM 4592 N N . GLY B 1 273 ? 42.248 88.565 90.069 1.00 37.31 ? 339 GLY B N 1 ATOM 4593 C CA . GLY B 1 273 ? 40.910 88.777 90.608 1.00 37.18 ? 339 GLY B CA 1 ATOM 4594 C C . GLY B 1 273 ? 40.473 87.777 91.668 1.00 41.92 ? 339 GLY B C 1 ATOM 4595 O O . GLY B 1 273 ? 39.352 87.262 91.599 1.00 40.93 ? 339 GLY B O 1 ATOM 4596 N N . GLY B 1 274 ? 41.343 87.471 92.625 1.00 41.67 ? 340 GLY B N 1 ATOM 4597 C CA . GLY B 1 274 ? 40.993 86.544 93.704 1.00 43.55 ? 340 GLY B CA 1 ATOM 4598 C C . GLY B 1 274 ? 41.010 85.060 93.361 1.00 52.95 ? 340 GLY B C 1 ATOM 4599 O O . GLY B 1 274 ? 40.962 84.224 94.275 1.00 54.62 ? 340 GLY B O 1 ATOM 4600 N N . LYS B 1 275 ? 41.067 84.722 92.034 1.00 49.76 ? 341 LYS B N 1 ATOM 4601 C CA . LYS B 1 275 ? 41.141 83.370 91.468 1.00 47.65 ? 341 LYS B CA 1 ATOM 4602 C C . LYS B 1 275 ? 42.586 83.051 91.072 1.00 49.48 ? 341 LYS B C 1 ATOM 4603 O O . LYS B 1 275 ? 43.396 83.952 90.843 1.00 49.39 ? 341 LYS B O 1 ATOM 4604 C CB . LYS B 1 275 ? 40.195 83.220 90.275 1.00 49.35 ? 341 LYS B CB 1 ATOM 4605 N N . GLU B 1 276 ? 42.915 81.766 91.019 1.00 44.75 ? 342 GLU B N 1 ATOM 4606 C CA . GLU B 1 276 ? 44.256 81.301 90.693 1.00 43.05 ? 342 GLU B CA 1 ATOM 4607 C C . GLU B 1 276 ? 44.243 80.627 89.328 1.00 43.58 ? 342 GLU B C 1 ATOM 4608 O O . GLU B 1 276 ? 43.430 79.739 89.089 1.00 43.54 ? 342 GLU B O 1 ATOM 4609 C CB . GLU B 1 276 ? 44.777 80.361 91.801 1.00 44.47 ? 342 GLU B CB 1 ATOM 4610 C CG . GLU B 1 276 ? 45.263 81.083 93.063 1.00 57.34 ? 342 GLU B CG 1 ATOM 4611 C CD . GLU B 1 276 ? 46.630 81.754 93.016 1.00 80.96 ? 342 GLU B CD 1 ATOM 4612 O OE1 . GLU B 1 276 ? 47.404 81.481 92.073 1.00 78.38 ? 342 GLU B OE1 1 ATOM 4613 O OE2 . GLU B 1 276 ? 46.948 82.524 93.951 1.00 74.51 ? 342 GLU B OE2 1 ATOM 4614 N N . TYR B 1 277 ? 45.109 81.100 88.411 1.00 37.87 ? 343 TYR B N 1 ATOM 4615 C CA . TYR B 1 277 ? 45.260 80.610 87.033 1.00 35.76 ? 343 TYR B CA 1 ATOM 4616 C C . TYR B 1 277 ? 46.537 79.801 86.931 1.00 38.52 ? 343 TYR B C 1 ATOM 4617 O O . TYR B 1 277 ? 47.633 80.355 86.882 1.00 37.99 ? 343 TYR B O 1 ATOM 4618 C CB . TYR B 1 277 ? 45.177 81.785 86.024 1.00 36.07 ? 343 TYR B CB 1 ATOM 4619 C CG . TYR B 1 277 ? 43.785 82.373 85.994 1.00 35.20 ? 343 TYR B CG 1 ATOM 4620 C CD1 . TYR B 1 277 ? 42.794 81.817 85.187 1.00 36.25 ? 343 TYR B CD1 1 ATOM 4621 C CD2 . TYR B 1 277 ? 43.408 83.376 86.893 1.00 34.28 ? 343 TYR B CD2 1 ATOM 4622 C CE1 . TYR B 1 277 ? 41.479 82.265 85.246 1.00 34.48 ? 343 TYR B CE1 1 ATOM 4623 C CE2 . TYR B 1 277 ? 42.097 83.842 86.948 1.00 33.23 ? 343 TYR B CE2 1 ATOM 4624 C CZ . TYR B 1 277 ? 41.135 83.272 86.133 1.00 41.23 ? 343 TYR B CZ 1 ATOM 4625 O OH . TYR B 1 277 ? 39.841 83.707 86.190 1.00 42.89 ? 343 TYR B OH 1 ATOM 4626 N N . THR B 1 278 ? 46.379 78.471 86.952 1.00 35.70 ? 344 THR B N 1 ATOM 4627 C CA . THR B 1 278 ? 47.465 77.512 87.013 1.00 35.96 ? 344 THR B CA 1 ATOM 4628 C C . THR B 1 278 ? 47.791 76.829 85.680 1.00 39.99 ? 344 THR B C 1 ATOM 4629 O O . THR B 1 278 ? 46.920 76.280 84.996 1.00 39.16 ? 344 THR B O 1 ATOM 4630 C CB . THR B 1 278 ? 47.158 76.497 88.130 1.00 39.41 ? 344 THR B CB 1 ATOM 4631 O OG1 . THR B 1 278 ? 47.008 77.225 89.350 1.00 41.11 ? 344 THR B OG1 1 ATOM 4632 C CG2 . THR B 1 278 ? 48.250 75.481 88.323 1.00 33.95 ? 344 THR B CG2 1 ATOM 4633 N N . LEU B 1 279 ? 49.094 76.824 85.373 1.00 35.74 ? 345 LEU B N 1 ATOM 4634 C CA . LEU B 1 279 ? 49.707 76.169 84.229 1.00 35.38 ? 345 LEU B CA 1 ATOM 4635 C C . LEU B 1 279 ? 50.610 75.080 84.790 1.00 39.77 ? 345 LEU B C 1 ATOM 4636 O O . LEU B 1 279 ? 51.383 75.347 85.713 1.00 39.42 ? 345 LEU B O 1 ATOM 4637 C CB . LEU B 1 279 ? 50.571 77.183 83.441 1.00 35.47 ? 345 LEU B CB 1 ATOM 4638 C CG . LEU B 1 279 ? 49.854 78.113 82.442 1.00 39.29 ? 345 LEU B CG 1 ATOM 4639 C CD1 . LEU B 1 279 ? 49.086 79.272 83.072 1.00 39.40 ? 345 LEU B CD1 1 ATOM 4640 C CD2 . LEU B 1 279 ? 50.773 78.530 81.369 1.00 40.39 ? 345 LEU B CD2 1 ATOM 4641 N N . THR B 1 280 ? 50.515 73.860 84.245 1.00 36.09 ? 346 THR B N 1 ATOM 4642 C CA . THR B 1 280 ? 51.375 72.744 84.616 1.00 35.80 ? 346 THR B CA 1 ATOM 4643 C C . THR B 1 280 ? 52.585 72.815 83.679 1.00 43.17 ? 346 THR B C 1 ATOM 4644 O O . THR B 1 280 ? 52.582 73.623 82.741 1.00 43.33 ? 346 THR B O 1 ATOM 4645 C CB . THR B 1 280 ? 50.634 71.404 84.515 1.00 40.35 ? 346 THR B CB 1 ATOM 4646 O OG1 . THR B 1 280 ? 50.361 71.112 83.153 1.00 39.53 ? 346 THR B OG1 1 ATOM 4647 C CG2 . THR B 1 280 ? 49.340 71.367 85.335 1.00 35.30 ? 346 THR B CG2 1 ATOM 4648 N N . SER B 1 281 ? 53.615 71.966 83.909 1.00 40.94 ? 347 SER B N 1 ATOM 4649 C CA . SER B 1 281 ? 54.819 71.918 83.064 1.00 39.34 ? 347 SER B CA 1 ATOM 4650 C C . SER B 1 281 ? 54.487 71.623 81.594 1.00 40.92 ? 347 SER B C 1 ATOM 4651 O O . SER B 1 281 ? 55.104 72.193 80.698 1.00 41.80 ? 347 SER B O 1 ATOM 4652 C CB . SER B 1 281 ? 55.828 70.922 83.617 1.00 42.11 ? 347 SER B CB 1 ATOM 4653 O OG . SER B 1 281 ? 55.238 69.653 83.847 1.00 50.04 ? 347 SER B OG 1 ATOM 4654 N N . ALA B 1 282 ? 53.467 70.802 81.348 1.00 36.11 ? 348 ALA B N 1 ATOM 4655 C CA . ALA B 1 282 ? 53.023 70.466 79.995 1.00 35.83 ? 348 ALA B CA 1 ATOM 4656 C C . ALA B 1 282 ? 52.524 71.734 79.233 1.00 41.60 ? 348 ALA B C 1 ATOM 4657 O O . ALA B 1 282 ? 52.659 71.805 78.021 1.00 43.20 ? 348 ALA B O 1 ATOM 4658 C CB . ALA B 1 282 ? 51.928 69.408 80.069 1.00 35.67 ? 348 ALA B CB 1 ATOM 4659 N N . ASP B 1 283 ? 52.026 72.746 79.967 1.00 37.09 ? 349 ASP B N 1 ATOM 4660 C CA . ASP B 1 283 ? 51.525 74.012 79.422 1.00 36.02 ? 349 ASP B CA 1 ATOM 4661 C C . ASP B 1 283 ? 52.602 75.049 79.139 1.00 38.26 ? 349 ASP B C 1 ATOM 4662 O O . ASP B 1 283 ? 52.323 75.989 78.393 1.00 37.69 ? 349 ASP B O 1 ATOM 4663 C CB . ASP B 1 283 ? 50.500 74.642 80.382 1.00 37.45 ? 349 ASP B CB 1 ATOM 4664 C CG . ASP B 1 283 ? 49.266 73.803 80.623 1.00 41.21 ? 349 ASP B CG 1 ATOM 4665 O OD1 . ASP B 1 283 ? 48.711 73.261 79.640 1.00 39.02 ? 349 ASP B OD1 1 ATOM 4666 O OD2 . ASP B 1 283 ? 48.833 73.711 81.787 1.00 47.33 ? 349 ASP B OD2 1 ATOM 4667 N N . TYR B 1 284 ? 53.795 74.947 79.773 1.00 34.41 ? 350 TYR B N 1 ATOM 4668 C CA . TYR B 1 284 ? 54.835 75.955 79.540 1.00 34.07 ? 350 TYR B CA 1 ATOM 4669 C C . TYR B 1 284 ? 56.181 75.363 79.047 1.00 38.61 ? 350 TYR B C 1 ATOM 4670 O O . TYR B 1 284 ? 57.092 76.125 78.732 1.00 38.74 ? 350 TYR B O 1 ATOM 4671 C CB . TYR B 1 284 ? 55.022 76.890 80.757 1.00 33.80 ? 350 TYR B CB 1 ATOM 4672 C CG . TYR B 1 284 ? 55.585 76.238 82.004 1.00 35.49 ? 350 TYR B CG 1 ATOM 4673 C CD1 . TYR B 1 284 ? 56.963 76.087 82.178 1.00 37.18 ? 350 TYR B CD1 1 ATOM 4674 C CD2 . TYR B 1 284 ? 54.751 75.842 83.043 1.00 35.68 ? 350 TYR B CD2 1 ATOM 4675 C CE1 . TYR B 1 284 ? 57.488 75.489 83.326 1.00 36.87 ? 350 TYR B CE1 1 ATOM 4676 C CE2 . TYR B 1 284 ? 55.264 75.254 84.201 1.00 36.79 ? 350 TYR B CE2 1 ATOM 4677 C CZ . TYR B 1 284 ? 56.635 75.081 84.342 1.00 42.96 ? 350 TYR B CZ 1 ATOM 4678 O OH . TYR B 1 284 ? 57.151 74.507 85.489 1.00 36.34 ? 350 TYR B OH 1 ATOM 4679 N N . VAL B 1 285 ? 56.296 74.029 78.940 1.00 35.07 ? 351 VAL B N 1 ATOM 4680 C CA . VAL B 1 285 ? 57.513 73.406 78.410 1.00 35.20 ? 351 VAL B CA 1 ATOM 4681 C C . VAL B 1 285 ? 57.258 72.981 76.968 1.00 39.44 ? 351 VAL B C 1 ATOM 4682 O O . VAL B 1 285 ? 56.279 72.277 76.700 1.00 38.93 ? 351 VAL B O 1 ATOM 4683 C CB . VAL B 1 285 ? 58.052 72.207 79.255 1.00 38.83 ? 351 VAL B CB 1 ATOM 4684 C CG1 . VAL B 1 285 ? 59.308 71.617 78.617 1.00 38.41 ? 351 VAL B CG1 1 ATOM 4685 C CG2 . VAL B 1 285 ? 58.326 72.604 80.710 1.00 38.03 ? 351 VAL B CG2 1 ATOM 4686 N N . PHE B 1 286 ? 58.148 73.384 76.043 1.00 36.99 ? 352 PHE B N 1 ATOM 4687 C CA . PHE B 1 286 ? 58.029 72.944 74.660 1.00 36.64 ? 352 PHE B CA 1 ATOM 4688 C C . PHE B 1 286 ? 58.707 71.591 74.620 1.00 41.57 ? 352 PHE B C 1 ATOM 4689 O O . PHE B 1 286 ? 59.925 71.492 74.444 1.00 40.47 ? 352 PHE B O 1 ATOM 4690 C CB . PHE B 1 286 ? 58.686 73.933 73.688 1.00 37.97 ? 352 PHE B CB 1 ATOM 4691 C CG . PHE B 1 286 ? 57.943 75.223 73.459 1.00 39.01 ? 352 PHE B CG 1 ATOM 4692 C CD1 . PHE B 1 286 ? 56.659 75.221 72.926 1.00 41.75 ? 352 PHE B CD1 1 ATOM 4693 C CD2 . PHE B 1 286 ? 58.565 76.442 73.670 1.00 40.00 ? 352 PHE B CD2 1 ATOM 4694 C CE1 . PHE B 1 286 ? 55.995 76.419 72.648 1.00 41.96 ? 352 PHE B CE1 1 ATOM 4695 C CE2 . PHE B 1 286 ? 57.902 77.635 73.399 1.00 41.99 ? 352 PHE B CE2 1 ATOM 4696 C CZ . PHE B 1 286 ? 56.615 77.617 72.889 1.00 40.10 ? 352 PHE B CZ 1 ATOM 4697 N N . GLN B 1 287 ? 57.918 70.546 74.857 1.00 39.01 ? 353 GLN B N 1 ATOM 4698 C CA . GLN B 1 287 ? 58.403 69.174 74.914 1.00 38.24 ? 353 GLN B CA 1 ATOM 4699 C C . GLN B 1 287 ? 58.648 68.603 73.522 1.00 44.59 ? 353 GLN B C 1 ATOM 4700 O O . GLN B 1 287 ? 57.970 67.656 73.114 1.00 44.13 ? 353 GLN B O 1 ATOM 4701 C CB . GLN B 1 287 ? 57.427 68.303 75.721 1.00 38.52 ? 353 GLN B CB 1 ATOM 4702 C CG . GLN B 1 287 ? 57.322 68.676 77.210 1.00 38.74 ? 353 GLN B CG 1 ATOM 4703 C CD . GLN B 1 287 ? 58.457 68.213 78.127 1.00 50.75 ? 353 GLN B CD 1 ATOM 4704 O OE1 . GLN B 1 287 ? 58.400 68.393 79.344 1.00 50.05 ? 353 GLN B OE1 1 ATOM 4705 N NE2 . GLN B 1 287 ? 59.522 67.635 77.594 1.00 36.75 ? 353 GLN B NE2 1 ATOM 4706 N N . GLU B 1 288 ? 59.642 69.168 72.793 1.00 43.85 ? 354 GLU B N 1 ATOM 4707 C CA . GLU B 1 288 ? 60.040 68.707 71.455 1.00 44.98 ? 354 GLU B CA 1 ATOM 4708 C C . GLU B 1 288 ? 60.462 67.231 71.468 1.00 50.89 ? 354 GLU B C 1 ATOM 4709 O O . GLU B 1 288 ? 60.495 66.610 70.407 1.00 51.65 ? 354 GLU B O 1 ATOM 4710 C CB . GLU B 1 288 ? 61.133 69.616 70.853 1.00 46.62 ? 354 GLU B CB 1 ATOM 4711 N N . SER B 1 289 ? 60.721 66.666 72.695 1.00 48.32 ? 355 SER B N 1 ATOM 4712 C CA . SER B 1 289 ? 61.080 65.285 73.030 1.00 48.56 ? 355 SER B CA 1 ATOM 4713 C C . SER B 1 289 ? 60.989 65.117 74.557 1.00 54.87 ? 355 SER B C 1 ATOM 4714 O O . SER B 1 289 ? 60.749 66.095 75.263 1.00 55.43 ? 355 SER B O 1 ATOM 4715 C CB . SER B 1 289 ? 62.485 64.950 72.510 1.00 51.12 ? 355 SER B CB 1 ATOM 4716 O OG . SER B 1 289 ? 63.503 65.037 73.493 1.00 61.00 ? 355 SER B OG 1 ATOM 4717 N N . TYR B 1 290 ? 61.183 63.900 75.068 1.00 52.38 ? 356 TYR B N 1 ATOM 4718 C CA . TYR B 1 290 ? 61.197 63.641 76.520 1.00 52.44 ? 356 TYR B CA 1 ATOM 4719 C C . TYR B 1 290 ? 62.504 62.905 76.893 1.00 53.86 ? 356 TYR B C 1 ATOM 4720 O O . TYR B 1 290 ? 62.614 62.273 77.950 1.00 52.25 ? 356 TYR B O 1 ATOM 4721 C CB . TYR B 1 290 ? 59.926 62.896 76.970 1.00 54.29 ? 356 TYR B CB 1 ATOM 4722 C CG . TYR B 1 290 ? 58.665 63.730 76.831 1.00 58.26 ? 356 TYR B CG 1 ATOM 4723 C CD1 . TYR B 1 290 ? 58.005 63.836 75.607 1.00 60.47 ? 356 TYR B CD1 1 ATOM 4724 C CD2 . TYR B 1 290 ? 58.108 64.383 77.933 1.00 59.09 ? 356 TYR B CD2 1 ATOM 4725 C CE1 . TYR B 1 290 ? 56.856 64.614 75.469 1.00 62.33 ? 356 TYR B CE1 1 ATOM 4726 C CE2 . TYR B 1 290 ? 56.934 65.132 77.815 1.00 59.78 ? 356 TYR B CE2 1 ATOM 4727 C CZ . TYR B 1 290 ? 56.305 65.236 76.581 1.00 69.84 ? 356 TYR B CZ 1 ATOM 4728 O OH . TYR B 1 290 ? 55.160 65.993 76.432 1.00 70.63 ? 356 TYR B OH 1 ATOM 4729 N N . SER B 1 291 ? 63.502 63.029 75.999 1.00 49.98 ? 357 SER B N 1 ATOM 4730 C CA . SER B 1 291 ? 64.825 62.421 76.115 1.00 49.38 ? 357 SER B CA 1 ATOM 4731 C C . SER B 1 291 ? 65.731 63.106 77.132 1.00 50.14 ? 357 SER B C 1 ATOM 4732 O O . SER B 1 291 ? 65.880 64.335 77.125 1.00 47.57 ? 357 SER B O 1 ATOM 4733 C CB . SER B 1 291 ? 65.517 62.380 74.754 1.00 52.41 ? 357 SER B CB 1 ATOM 4734 O OG . SER B 1 291 ? 66.865 61.970 74.886 1.00 61.23 ? 357 SER B OG 1 ATOM 4735 N N . SER B 1 292 ? 66.395 62.266 77.952 1.00 46.16 ? 358 SER B N 1 ATOM 4736 C CA . SER B 1 292 ? 67.414 62.636 78.940 1.00 46.06 ? 358 SER B CA 1 ATOM 4737 C C . SER B 1 292 ? 68.715 63.105 78.248 1.00 48.55 ? 358 SER B C 1 ATOM 4738 O O . SER B 1 292 ? 69.606 63.645 78.918 1.00 48.01 ? 358 SER B O 1 ATOM 4739 C CB . SER B 1 292 ? 67.717 61.450 79.860 1.00 49.60 ? 358 SER B CB 1 ATOM 4740 O OG . SER B 1 292 ? 68.057 60.279 79.129 1.00 55.97 ? 358 SER B OG 1 ATOM 4741 N N . LYS B 1 293 ? 68.777 62.946 76.914 1.00 45.10 ? 359 LYS B N 1 ATOM 4742 C CA . LYS B 1 293 ? 69.895 63.299 76.032 1.00 44.96 ? 359 LYS B CA 1 ATOM 4743 C C . LYS B 1 293 ? 69.681 64.636 75.302 1.00 48.56 ? 359 LYS B C 1 ATOM 4744 O O . LYS B 1 293 ? 70.569 65.083 74.581 1.00 48.22 ? 359 LYS B O 1 ATOM 4745 C CB . LYS B 1 293 ? 70.157 62.126 75.034 1.00 47.11 ? 359 LYS B CB 1 ATOM 4746 C CG . LYS B 1 293 ? 70.243 60.749 75.733 1.00 37.18 ? 359 LYS B CG 1 ATOM 4747 C CD . LYS B 1 293 ? 69.663 59.600 74.928 1.00 51.72 ? 359 LYS B CD 1 ATOM 4748 C CE . LYS B 1 293 ? 69.659 58.268 75.676 1.00 56.05 ? 359 LYS B CE 1 ATOM 4749 N NZ . LYS B 1 293 ? 68.699 58.255 76.811 1.00 58.60 ? 359 LYS B NZ 1 ATOM 4750 N N . LYS B 1 294 ? 68.537 65.299 75.549 1.00 47.25 ? 360 LYS B N 1 ATOM 4751 C CA . LYS B 1 294 ? 68.151 66.573 74.925 1.00 47.16 ? 360 LYS B CA 1 ATOM 4752 C C . LYS B 1 294 ? 67.683 67.659 75.897 1.00 49.02 ? 360 LYS B C 1 ATOM 4753 O O . LYS B 1 294 ? 67.216 67.338 76.989 1.00 48.31 ? 360 LYS B O 1 ATOM 4754 C CB . LYS B 1 294 ? 67.077 66.321 73.854 1.00 49.89 ? 360 LYS B CB 1 ATOM 4755 C CG . LYS B 1 294 ? 67.688 66.125 72.480 1.00 62.27 ? 360 LYS B CG 1 ATOM 4756 C CD . LYS B 1 294 ? 67.210 64.852 71.836 1.00 72.33 ? 360 LYS B CD 1 ATOM 4757 C CE . LYS B 1 294 ? 67.917 64.589 70.528 1.00 83.96 ? 360 LYS B CE 1 ATOM 4758 N NZ . LYS B 1 294 ? 67.346 65.392 69.413 1.00 97.48 ? 360 LYS B NZ 1 ATOM 4759 N N . LEU B 1 295 ? 67.793 68.945 75.471 1.00 45.36 ? 361 LEU B N 1 ATOM 4760 C CA . LEU B 1 295 ? 67.362 70.157 76.197 1.00 45.03 ? 361 LEU B CA 1 ATOM 4761 C C . LEU B 1 295 ? 66.133 70.778 75.531 1.00 49.38 ? 361 LEU B C 1 ATOM 4762 O O . LEU B 1 295 ? 66.133 70.969 74.311 1.00 49.81 ? 361 LEU B O 1 ATOM 4763 C CB . LEU B 1 295 ? 68.475 71.207 76.270 1.00 44.77 ? 361 LEU B CB 1 ATOM 4764 C CG . LEU B 1 295 ? 69.824 70.778 76.824 1.00 48.16 ? 361 LEU B CG 1 ATOM 4765 C CD1 . LEU B 1 295 ? 70.821 71.923 76.735 1.00 47.88 ? 361 LEU B CD1 1 ATOM 4766 C CD2 . LEU B 1 295 ? 69.699 70.288 78.231 1.00 48.70 ? 361 LEU B CD2 1 ATOM 4767 N N . CYS B 1 296 ? 65.094 71.100 76.345 1.00 44.91 ? 362 CYS B N 1 ATOM 4768 C CA . CYS B 1 296 ? 63.783 71.618 75.953 1.00 43.97 ? 362 CYS B CA 1 ATOM 4769 C C . CYS B 1 296 ? 63.588 73.061 76.398 1.00 48.53 ? 362 CYS B C 1 ATOM 4770 O O . CYS B 1 296 ? 63.863 73.382 77.556 1.00 48.66 ? 362 CYS B O 1 ATOM 4771 C CB . CYS B 1 296 ? 62.685 70.716 76.504 1.00 44.11 ? 362 CYS B CB 1 ATOM 4772 S SG . CYS B 1 296 ? 62.337 69.256 75.489 1.00 48.40 ? 362 CYS B SG 1 ATOM 4773 N N . THR B 1 297 ? 63.111 73.930 75.482 1.00 44.60 ? 363 THR B N 1 ATOM 4774 C CA . THR B 1 297 ? 62.862 75.348 75.745 1.00 44.24 ? 363 THR B CA 1 ATOM 4775 C C . THR B 1 297 ? 61.556 75.564 76.515 1.00 46.60 ? 363 THR B C 1 ATOM 4776 O O . THR B 1 297 ? 60.648 74.730 76.480 1.00 44.64 ? 363 THR B O 1 ATOM 4777 C CB . THR B 1 297 ? 62.845 76.155 74.436 1.00 51.22 ? 363 THR B CB 1 ATOM 4778 O OG1 . THR B 1 297 ? 61.975 75.505 73.514 1.00 55.55 ? 363 THR B OG1 1 ATOM 4779 C CG2 . THR B 1 297 ? 64.224 76.310 73.829 1.00 45.67 ? 363 THR B CG2 1 ATOM 4780 N N . LEU B 1 298 ? 61.470 76.694 77.214 1.00 45.26 ? 364 LEU B N 1 ATOM 4781 C CA . LEU B 1 298 ? 60.277 77.062 77.987 1.00 45.16 ? 364 LEU B CA 1 ATOM 4782 C C . LEU B 1 298 ? 59.575 78.217 77.291 1.00 49.35 ? 364 LEU B C 1 ATOM 4783 O O . LEU B 1 298 ? 60.231 79.083 76.710 1.00 50.48 ? 364 LEU B O 1 ATOM 4784 C CB . LEU B 1 298 ? 60.623 77.400 79.451 1.00 45.37 ? 364 LEU B CB 1 ATOM 4785 C CG . LEU B 1 298 ? 61.593 76.403 80.205 1.00 51.38 ? 364 LEU B CG 1 ATOM 4786 C CD1 . LEU B 1 298 ? 61.749 76.791 81.648 1.00 52.64 ? 364 LEU B CD1 1 ATOM 4787 C CD2 . LEU B 1 298 ? 61.065 74.994 80.221 1.00 54.24 ? 364 LEU B CD2 1 ATOM 4788 N N . ALA B 1 299 ? 58.238 78.196 77.288 1.00 43.48 ? 365 ALA B N 1 ATOM 4789 C CA . ALA B 1 299 ? 57.355 79.186 76.684 1.00 41.36 ? 365 ALA B CA 1 ATOM 4790 C C . ALA B 1 299 ? 57.130 80.408 77.593 1.00 44.41 ? 365 ALA B C 1 ATOM 4791 O O . ALA B 1 299 ? 56.062 81.041 77.546 1.00 44.24 ? 365 ALA B O 1 ATOM 4792 C CB . ALA B 1 299 ? 56.034 78.527 76.336 1.00 41.92 ? 365 ALA B CB 1 ATOM 4793 N N . ILE B 1 300 ? 58.146 80.730 78.417 1.00 40.80 ? 366 ILE B N 1 ATOM 4794 C CA . ILE B 1 300 ? 58.221 81.876 79.326 1.00 41.90 ? 366 ILE B CA 1 ATOM 4795 C C . ILE B 1 300 ? 59.558 82.552 79.055 1.00 46.01 ? 366 ILE B C 1 ATOM 4796 O O . ILE B 1 300 ? 60.588 81.877 79.067 1.00 46.83 ? 366 ILE B O 1 ATOM 4797 C CB . ILE B 1 300 ? 58.052 81.489 80.835 1.00 45.45 ? 366 ILE B CB 1 ATOM 4798 C CG1 . ILE B 1 300 ? 56.728 80.738 81.100 1.00 45.70 ? 366 ILE B CG1 1 ATOM 4799 C CG2 . ILE B 1 300 ? 58.167 82.727 81.746 1.00 45.37 ? 366 ILE B CG2 1 ATOM 4800 C CD1 . ILE B 1 300 ? 56.754 79.853 82.353 1.00 52.13 ? 366 ILE B CD1 1 ATOM 4801 N N . HIS B 1 301 ? 59.537 83.860 78.764 1.00 43.36 ? 367 HIS B N 1 ATOM 4802 C CA . HIS B 1 301 ? 60.718 84.654 78.446 1.00 45.11 ? 367 HIS B CA 1 ATOM 4803 C C . HIS B 1 301 ? 60.788 85.948 79.251 1.00 53.87 ? 367 HIS B C 1 ATOM 4804 O O . HIS B 1 301 ? 59.786 86.395 79.806 1.00 55.16 ? 367 HIS B O 1 ATOM 4805 C CB . HIS B 1 301 ? 60.747 84.987 76.940 1.00 46.41 ? 367 HIS B CB 1 ATOM 4806 C CG . HIS B 1 301 ? 61.075 83.812 76.054 1.00 50.32 ? 367 HIS B CG 1 ATOM 4807 N ND1 . HIS B 1 301 ? 62.165 83.834 75.183 1.00 52.60 ? 367 HIS B ND1 1 ATOM 4808 C CD2 . HIS B 1 301 ? 60.435 82.628 75.912 1.00 52.12 ? 367 HIS B CD2 1 ATOM 4809 C CE1 . HIS B 1 301 ? 62.152 82.665 74.560 1.00 51.71 ? 367 HIS B CE1 1 ATOM 4810 N NE2 . HIS B 1 301 ? 61.138 81.899 74.974 1.00 51.94 ? 367 HIS B NE2 1 ATOM 4811 N N . ALA B 1 302 ? 61.983 86.554 79.302 1.00 51.93 ? 368 ALA B N 1 ATOM 4812 C CA . ALA B 1 302 ? 62.198 87.836 79.944 1.00 51.86 ? 368 ALA B CA 1 ATOM 4813 C C . ALA B 1 302 ? 61.900 88.927 78.907 1.00 56.22 ? 368 ALA B C 1 ATOM 4814 O O . ALA B 1 302 ? 62.250 88.780 77.733 1.00 55.85 ? 368 ALA B O 1 ATOM 4815 C CB . ALA B 1 302 ? 63.635 87.940 80.405 1.00 52.51 ? 368 ALA B CB 1 ATOM 4816 N N . MET B 1 303 ? 61.216 89.990 79.328 1.00 54.02 ? 369 MET B N 1 ATOM 4817 C CA . MET B 1 303 ? 60.884 91.127 78.472 1.00 54.98 ? 369 MET B CA 1 ATOM 4818 C C . MET B 1 303 ? 60.687 92.349 79.353 1.00 56.49 ? 369 MET B C 1 ATOM 4819 O O . MET B 1 303 ? 59.758 92.387 80.152 1.00 56.18 ? 369 MET B O 1 ATOM 4820 C CB . MET B 1 303 ? 59.643 90.835 77.602 1.00 58.56 ? 369 MET B CB 1 ATOM 4821 C CG . MET B 1 303 ? 59.224 91.993 76.691 1.00 64.77 ? 369 MET B CG 1 ATOM 4822 S SD . MET B 1 303 ? 60.291 92.291 75.237 1.00 71.78 ? 369 MET B SD 1 ATOM 4823 C CE . MET B 1 303 ? 59.648 91.084 74.139 1.00 68.81 ? 369 MET B CE 1 ATOM 4824 N N . ASP B 1 304 ? 61.580 93.328 79.234 1.00 51.45 ? 370 ASP B N 1 ATOM 4825 C CA . ASP B 1 304 ? 61.486 94.557 80.013 1.00 51.46 ? 370 ASP B CA 1 ATOM 4826 C C . ASP B 1 304 ? 60.682 95.580 79.231 1.00 56.15 ? 370 ASP B C 1 ATOM 4827 O O . ASP B 1 304 ? 61.171 96.132 78.244 1.00 54.97 ? 370 ASP B O 1 ATOM 4828 C CB . ASP B 1 304 ? 62.885 95.077 80.413 1.00 52.86 ? 370 ASP B CB 1 ATOM 4829 C CG . ASP B 1 304 ? 63.642 94.107 81.304 1.00 58.29 ? 370 ASP B CG 1 ATOM 4830 O OD1 . ASP B 1 304 ? 63.085 93.705 82.357 1.00 58.62 ? 370 ASP B OD1 1 ATOM 4831 O OD2 . ASP B 1 304 ? 64.775 93.726 80.937 1.00 59.57 ? 370 ASP B OD2 1 ATOM 4832 N N . ILE B 1 305 ? 59.411 95.752 79.612 1.00 54.36 ? 371 ILE B N 1 ATOM 4833 C CA . ILE B 1 305 ? 58.520 96.683 78.932 1.00 55.26 ? 371 ILE B CA 1 ATOM 4834 C C . ILE B 1 305 ? 58.706 98.068 79.556 1.00 63.23 ? 371 ILE B C 1 ATOM 4835 O O . ILE B 1 305 ? 58.671 98.185 80.780 1.00 63.36 ? 371 ILE B O 1 ATOM 4836 C CB . ILE B 1 305 ? 57.049 96.163 78.853 1.00 57.99 ? 371 ILE B CB 1 ATOM 4837 C CG1 . ILE B 1 305 ? 56.978 94.928 77.914 1.00 57.75 ? 371 ILE B CG1 1 ATOM 4838 C CG2 . ILE B 1 305 ? 56.059 97.265 78.372 1.00 57.99 ? 371 ILE B CG2 1 ATOM 4839 C CD1 . ILE B 1 305 ? 56.111 93.829 78.401 1.00 62.57 ? 371 ILE B CD1 1 ATOM 4840 N N . PRO B 1 306 ? 59.008 99.106 78.739 1.00 62.62 ? 372 PRO B N 1 ATOM 4841 C CA . PRO B 1 306 ? 59.257 100.433 79.314 1.00 63.49 ? 372 PRO B CA 1 ATOM 4842 C C . PRO B 1 306 ? 57.995 101.177 79.776 1.00 69.47 ? 372 PRO B C 1 ATOM 4843 O O . PRO B 1 306 ? 56.901 100.877 79.281 1.00 69.54 ? 372 PRO B O 1 ATOM 4844 C CB . PRO B 1 306 ? 59.993 101.170 78.183 1.00 65.01 ? 372 PRO B CB 1 ATOM 4845 C CG . PRO B 1 306 ? 59.511 100.548 76.946 1.00 69.06 ? 372 PRO B CG 1 ATOM 4846 C CD . PRO B 1 306 ? 59.149 99.122 77.265 1.00 64.62 ? 372 PRO B CD 1 ATOM 4847 N N . PRO B 1 307 ? 58.123 102.182 80.686 1.00 66.41 ? 373 PRO B N 1 ATOM 4848 C CA . PRO B 1 307 ? 56.935 102.943 81.108 1.00 65.89 ? 373 PRO B CA 1 ATOM 4849 C C . PRO B 1 307 ? 56.283 103.731 79.954 1.00 68.54 ? 373 PRO B C 1 ATOM 4850 O O . PRO B 1 307 ? 56.914 103.900 78.905 1.00 67.23 ? 373 PRO B O 1 ATOM 4851 C CB . PRO B 1 307 ? 57.468 103.853 82.233 1.00 67.84 ? 373 PRO B CB 1 ATOM 4852 C CG . PRO B 1 307 ? 58.772 103.253 82.648 1.00 72.51 ? 373 PRO B CG 1 ATOM 4853 C CD . PRO B 1 307 ? 59.332 102.669 81.384 1.00 68.05 ? 373 PRO B CD 1 ATOM 4854 N N . PRO B 1 308 ? 55.001 104.159 80.074 1.00 64.75 ? 374 PRO B N 1 ATOM 4855 C CA . PRO B 1 308 ? 54.100 104.033 81.243 1.00 64.10 ? 374 PRO B CA 1 ATOM 4856 C C . PRO B 1 308 ? 53.469 102.643 81.432 1.00 66.72 ? 374 PRO B C 1 ATOM 4857 O O . PRO B 1 308 ? 53.045 102.328 82.549 1.00 66.54 ? 374 PRO B O 1 ATOM 4858 C CB . PRO B 1 308 ? 53.067 105.139 80.998 1.00 65.81 ? 374 PRO B CB 1 ATOM 4859 C CG . PRO B 1 308 ? 52.975 105.228 79.496 1.00 70.17 ? 374 PRO B CG 1 ATOM 4860 C CD . PRO B 1 308 ? 54.357 104.897 78.967 1.00 65.64 ? 374 PRO B CD 1 ATOM 4861 N N . THR B 1 309 ? 53.419 101.812 80.362 1.00 61.79 ? 375 THR B N 1 ATOM 4862 C CA . THR B 1 309 ? 52.816 100.469 80.395 1.00 60.87 ? 375 THR B CA 1 ATOM 4863 C C . THR B 1 309 ? 53.563 99.524 81.354 1.00 61.86 ? 375 THR B C 1 ATOM 4864 O O . THR B 1 309 ? 52.930 98.866 82.186 1.00 59.22 ? 375 THR B O 1 ATOM 4865 C CB . THR B 1 309 ? 52.664 99.896 78.975 1.00 68.70 ? 375 THR B CB 1 ATOM 4866 O OG1 . THR B 1 309 ? 52.068 100.880 78.114 1.00 69.59 ? 375 THR B OG1 1 ATOM 4867 C CG2 . THR B 1 309 ? 51.817 98.639 78.957 1.00 68.10 ? 375 THR B CG2 1 ATOM 4868 N N . GLY B 1 310 ? 54.889 99.489 81.227 1.00 58.62 ? 376 GLY B N 1 ATOM 4869 C CA . GLY B 1 310 ? 55.757 98.668 82.063 1.00 57.94 ? 376 GLY B CA 1 ATOM 4870 C C . GLY B 1 310 ? 56.411 99.421 83.216 1.00 60.22 ? 376 GLY B C 1 ATOM 4871 O O . GLY B 1 310 ? 56.244 100.640 83.330 1.00 59.70 ? 376 GLY B O 1 ATOM 4872 N N . PRO B 1 311 ? 57.191 98.748 84.098 1.00 55.13 ? 377 PRO B N 1 ATOM 4873 C CA . PRO B 1 311 ? 57.487 97.300 84.148 1.00 53.39 ? 377 PRO B CA 1 ATOM 4874 C C . PRO B 1 311 ? 56.209 96.501 84.369 1.00 54.58 ? 377 PRO B C 1 ATOM 4875 O O . PRO B 1 311 ? 55.367 96.886 85.192 1.00 55.37 ? 377 PRO B O 1 ATOM 4876 C CB . PRO B 1 311 ? 58.466 97.176 85.328 1.00 55.32 ? 377 PRO B CB 1 ATOM 4877 C CG . PRO B 1 311 ? 59.002 98.572 85.545 1.00 60.61 ? 377 PRO B CG 1 ATOM 4878 C CD . PRO B 1 311 ? 57.846 99.460 85.209 1.00 56.46 ? 377 PRO B CD 1 ATOM 4879 N N . THR B 1 312 ? 56.028 95.427 83.575 1.00 46.99 ? 378 THR B N 1 ATOM 4880 C CA . THR B 1 312 ? 54.827 94.593 83.612 1.00 43.70 ? 378 THR B CA 1 ATOM 4881 C C . THR B 1 312 ? 55.085 93.172 83.149 1.00 45.90 ? 378 THR B C 1 ATOM 4882 O O . THR B 1 312 ? 56.027 92.897 82.380 1.00 43.99 ? 378 THR B O 1 ATOM 4883 C CB . THR B 1 312 ? 53.704 95.241 82.741 1.00 39.10 ? 378 THR B CB 1 ATOM 4884 O OG1 . THR B 1 312 ? 52.512 94.496 82.876 1.00 33.85 ? 378 THR B OG1 1 ATOM 4885 C CG2 . THR B 1 312 ? 54.064 95.357 81.252 1.00 34.14 ? 378 THR B CG2 1 ATOM 4886 N N . TRP B 1 313 ? 54.198 92.263 83.583 1.00 40.34 ? 379 TRP B N 1 ATOM 4887 C CA . TRP B 1 313 ? 54.190 90.929 83.026 1.00 38.05 ? 379 TRP B CA 1 ATOM 4888 C C . TRP B 1 313 ? 53.305 91.029 81.776 1.00 40.65 ? 379 TRP B C 1 ATOM 4889 O O . TRP B 1 313 ? 52.488 91.954 81.648 1.00 39.13 ? 379 TRP B O 1 ATOM 4890 C CB . TRP B 1 313 ? 53.571 89.918 83.981 1.00 35.81 ? 379 TRP B CB 1 ATOM 4891 C CG . TRP B 1 313 ? 54.415 89.610 85.172 1.00 36.23 ? 379 TRP B CG 1 ATOM 4892 C CD1 . TRP B 1 313 ? 54.594 90.398 86.277 1.00 38.97 ? 379 TRP B CD1 1 ATOM 4893 C CD2 . TRP B 1 313 ? 55.086 88.374 85.446 1.00 35.41 ? 379 TRP B CD2 1 ATOM 4894 N NE1 . TRP B 1 313 ? 55.351 89.738 87.210 1.00 37.61 ? 379 TRP B NE1 1 ATOM 4895 C CE2 . TRP B 1 313 ? 55.675 88.493 86.724 1.00 38.70 ? 379 TRP B CE2 1 ATOM 4896 C CE3 . TRP B 1 313 ? 55.257 87.173 84.727 1.00 36.27 ? 379 TRP B CE3 1 ATOM 4897 C CZ2 . TRP B 1 313 ? 56.439 87.466 87.295 1.00 37.88 ? 379 TRP B CZ2 1 ATOM 4898 C CZ3 . TRP B 1 313 ? 56.016 86.157 85.295 1.00 37.41 ? 379 TRP B CZ3 1 ATOM 4899 C CH2 . TRP B 1 313 ? 56.593 86.306 86.563 1.00 38.04 ? 379 TRP B CH2 1 ATOM 4900 N N . ALA B 1 314 ? 53.467 90.097 80.860 1.00 37.90 ? 380 ALA B N 1 ATOM 4901 C CA . ALA B 1 314 ? 52.598 90.025 79.684 1.00 37.47 ? 380 ALA B CA 1 ATOM 4902 C C . ALA B 1 314 ? 52.144 88.588 79.567 1.00 40.28 ? 380 ALA B C 1 ATOM 4903 O O . ALA B 1 314 ? 52.962 87.669 79.654 1.00 39.95 ? 380 ALA B O 1 ATOM 4904 C CB . ALA B 1 314 ? 53.323 90.479 78.425 1.00 37.83 ? 380 ALA B CB 1 ATOM 4905 N N . LEU B 1 315 ? 50.837 88.386 79.470 1.00 36.26 ? 381 LEU B N 1 ATOM 4906 C CA . LEU B 1 315 ? 50.248 87.060 79.338 1.00 35.14 ? 381 LEU B CA 1 ATOM 4907 C C . LEU B 1 315 ? 49.898 86.882 77.863 1.00 36.78 ? 381 LEU B C 1 ATOM 4908 O O . LEU B 1 315 ? 48.891 87.400 77.389 1.00 34.67 ? 381 LEU B O 1 ATOM 4909 C CB . LEU B 1 315 ? 49.042 86.877 80.296 1.00 34.83 ? 381 LEU B CB 1 ATOM 4910 C CG . LEU B 1 315 ? 49.313 87.159 81.796 1.00 38.36 ? 381 LEU B CG 1 ATOM 4911 C CD1 . LEU B 1 315 ? 48.020 87.212 82.599 1.00 37.26 ? 381 LEU B CD1 1 ATOM 4912 C CD2 . LEU B 1 315 ? 50.301 86.134 82.405 1.00 39.78 ? 381 LEU B CD2 1 ATOM 4913 N N . GLY B 1 316 ? 50.819 86.242 77.141 1.00 34.39 ? 382 GLY B N 1 ATOM 4914 C CA . GLY B 1 316 ? 50.720 85.984 75.708 1.00 34.28 ? 382 GLY B CA 1 ATOM 4915 C C . GLY B 1 316 ? 50.103 84.642 75.391 1.00 39.76 ? 382 GLY B C 1 ATOM 4916 O O . GLY B 1 316 ? 49.400 84.057 76.227 1.00 40.68 ? 382 GLY B O 1 ATOM 4917 N N . ALA B 1 317 ? 50.398 84.121 74.187 1.00 36.24 ? 383 ALA B N 1 ATOM 4918 C CA . ALA B 1 317 ? 49.856 82.854 73.693 1.00 36.07 ? 383 ALA B CA 1 ATOM 4919 C C . ALA B 1 317 ? 50.001 81.675 74.670 1.00 38.35 ? 383 ALA B C 1 ATOM 4920 O O . ALA B 1 317 ? 49.084 80.865 74.741 1.00 37.93 ? 383 ALA B O 1 ATOM 4921 C CB . ALA B 1 317 ? 50.440 82.519 72.330 1.00 36.88 ? 383 ALA B CB 1 ATOM 4922 N N . THR B 1 318 ? 51.088 81.610 75.468 1.00 34.58 ? 384 THR B N 1 ATOM 4923 C CA . THR B 1 318 ? 51.265 80.539 76.470 1.00 34.02 ? 384 THR B CA 1 ATOM 4924 C C . THR B 1 318 ? 50.066 80.490 77.437 1.00 37.94 ? 384 THR B C 1 ATOM 4925 O O . THR B 1 318 ? 49.545 79.408 77.725 1.00 37.87 ? 384 THR B O 1 ATOM 4926 C CB . THR B 1 318 ? 52.583 80.714 77.230 1.00 39.63 ? 384 THR B CB 1 ATOM 4927 O OG1 . THR B 1 318 ? 53.640 80.923 76.294 1.00 42.20 ? 384 THR B OG1 1 ATOM 4928 C CG2 . THR B 1 318 ? 52.905 79.530 78.157 1.00 33.78 ? 384 THR B CG2 1 ATOM 4929 N N . PHE B 1 319 ? 49.626 81.673 77.906 1.00 33.97 ? 385 PHE B N 1 ATOM 4930 C CA . PHE B 1 319 ? 48.505 81.807 78.834 1.00 32.76 ? 385 PHE B CA 1 ATOM 4931 C C . PHE B 1 319 ? 47.153 81.567 78.175 1.00 34.10 ? 385 PHE B C 1 ATOM 4932 O O . PHE B 1 319 ? 46.339 80.824 78.716 1.00 34.25 ? 385 PHE B O 1 ATOM 4933 C CB . PHE B 1 319 ? 48.540 83.184 79.526 1.00 33.72 ? 385 PHE B CB 1 ATOM 4934 C CG . PHE B 1 319 ? 47.641 83.261 80.745 1.00 34.56 ? 385 PHE B CG 1 ATOM 4935 C CD1 . PHE B 1 319 ? 48.081 82.811 81.990 1.00 36.16 ? 385 PHE B CD1 1 ATOM 4936 C CD2 . PHE B 1 319 ? 46.351 83.768 80.647 1.00 35.57 ? 385 PHE B CD2 1 ATOM 4937 C CE1 . PHE B 1 319 ? 47.252 82.896 83.117 1.00 36.69 ? 385 PHE B CE1 1 ATOM 4938 C CE2 . PHE B 1 319 ? 45.518 83.827 81.772 1.00 37.77 ? 385 PHE B CE2 1 ATOM 4939 C CZ . PHE B 1 319 ? 45.980 83.409 82.999 1.00 36.25 ? 385 PHE B CZ 1 ATOM 4940 N N . ILE B 1 320 ? 46.925 82.190 77.006 1.00 29.25 ? 386 ILE B N 1 ATOM 4941 C CA . ILE B 1 320 ? 45.678 82.113 76.241 1.00 28.57 ? 386 ILE B CA 1 ATOM 4942 C C . ILE B 1 320 ? 45.375 80.675 75.775 1.00 33.14 ? 386 ILE B C 1 ATOM 4943 O O . ILE B 1 320 ? 44.199 80.291 75.771 1.00 31.98 ? 386 ILE B O 1 ATOM 4944 C CB . ILE B 1 320 ? 45.662 83.166 75.110 1.00 30.82 ? 386 ILE B CB 1 ATOM 4945 C CG1 . ILE B 1 320 ? 45.746 84.586 75.728 1.00 30.62 ? 386 ILE B CG1 1 ATOM 4946 C CG2 . ILE B 1 320 ? 44.417 83.015 74.205 1.00 31.04 ? 386 ILE B CG2 1 ATOM 4947 C CD1 . ILE B 1 320 ? 46.313 85.681 74.807 1.00 44.68 ? 386 ILE B CD1 1 ATOM 4948 N N . ARG B 1 321 ? 46.412 79.863 75.460 1.00 31.09 ? 387 ARG B N 1 ATOM 4949 C CA . ARG B 1 321 ? 46.203 78.460 75.074 1.00 31.62 ? 387 ARG B CA 1 ATOM 4950 C C . ARG B 1 321 ? 45.419 77.716 76.167 1.00 36.74 ? 387 ARG B C 1 ATOM 4951 O O . ARG B 1 321 ? 44.454 77.003 75.868 1.00 36.78 ? 387 ARG B O 1 ATOM 4952 C CB . ARG B 1 321 ? 47.535 77.727 74.804 1.00 30.41 ? 387 ARG B CB 1 ATOM 4953 C CG . ARG B 1 321 ? 48.022 77.870 73.375 1.00 31.78 ? 387 ARG B CG 1 ATOM 4954 C CD . ARG B 1 321 ? 49.163 76.903 73.030 1.00 26.90 ? 387 ARG B CD 1 ATOM 4955 N NE . ARG B 1 321 ? 50.440 77.226 73.675 1.00 25.57 ? 387 ARG B NE 1 ATOM 4956 C CZ . ARG B 1 321 ? 51.302 78.136 73.248 1.00 36.22 ? 387 ARG B CZ 1 ATOM 4957 N NH1 . ARG B 1 321 ? 51.028 78.868 72.173 1.00 34.39 ? 387 ARG B NH1 1 ATOM 4958 N NH2 . ARG B 1 321 ? 52.437 78.335 73.900 1.00 25.75 ? 387 ARG B NH2 1 ATOM 4959 N N . LYS B 1 322 ? 45.816 77.934 77.433 1.00 33.15 ? 388 LYS B N 1 ATOM 4960 C CA . LYS B 1 322 ? 45.190 77.338 78.610 1.00 32.28 ? 388 LYS B CA 1 ATOM 4961 C C . LYS B 1 322 ? 43.838 78.000 78.952 1.00 34.49 ? 388 LYS B C 1 ATOM 4962 O O . LYS B 1 322 ? 42.883 77.301 79.283 1.00 35.45 ? 388 LYS B O 1 ATOM 4963 C CB . LYS B 1 322 ? 46.172 77.417 79.798 1.00 33.12 ? 388 LYS B CB 1 ATOM 4964 C CG . LYS B 1 322 ? 45.674 76.740 81.074 1.00 35.09 ? 388 LYS B CG 1 ATOM 4965 C CD . LYS B 1 322 ? 45.867 75.251 81.081 1.00 41.03 ? 388 LYS B CD 1 ATOM 4966 C CE . LYS B 1 322 ? 45.469 74.632 82.378 1.00 38.57 ? 388 LYS B CE 1 ATOM 4967 N NZ . LYS B 1 322 ? 45.723 73.190 82.300 1.00 45.74 ? 388 LYS B NZ 1 ATOM 4968 N N . PHE B 1 323 ? 43.754 79.329 78.841 1.00 29.78 ? 389 PHE B N 1 ATOM 4969 C CA . PHE B 1 323 ? 42.539 80.055 79.179 1.00 29.09 ? 389 PHE B CA 1 ATOM 4970 C C . PHE B 1 323 ? 41.941 80.873 78.032 1.00 33.67 ? 389 PHE B C 1 ATOM 4971 O O . PHE B 1 323 ? 42.508 81.901 77.623 1.00 32.18 ? 389 PHE B O 1 ATOM 4972 C CB . PHE B 1 323 ? 42.776 80.955 80.419 1.00 30.07 ? 389 PHE B CB 1 ATOM 4973 C CG . PHE B 1 323 ? 43.263 80.188 81.618 1.00 31.34 ? 389 PHE B CG 1 ATOM 4974 C CD1 . PHE B 1 323 ? 42.395 79.367 82.340 1.00 32.19 ? 389 PHE B CD1 1 ATOM 4975 C CD2 . PHE B 1 323 ? 44.597 80.242 82.000 1.00 32.11 ? 389 PHE B CD2 1 ATOM 4976 C CE1 . PHE B 1 323 ? 42.848 78.621 83.413 1.00 32.47 ? 389 PHE B CE1 1 ATOM 4977 C CE2 . PHE B 1 323 ? 45.043 79.509 83.090 1.00 33.82 ? 389 PHE B CE2 1 ATOM 4978 C CZ . PHE B 1 323 ? 44.166 78.684 83.774 1.00 31.77 ? 389 PHE B CZ 1 ATOM 4979 N N . TYR B 1 324 ? 40.755 80.439 77.563 1.00 29.97 ? 390 TYR B N 1 ATOM 4980 C CA . TYR B 1 324 ? 39.939 81.139 76.584 1.00 29.74 ? 390 TYR B CA 1 ATOM 4981 C C . TYR B 1 324 ? 39.720 82.553 77.181 1.00 33.47 ? 390 TYR B C 1 ATOM 4982 O O . TYR B 1 324 ? 39.399 82.674 78.367 1.00 30.82 ? 390 TYR B O 1 ATOM 4983 C CB . TYR B 1 324 ? 38.589 80.404 76.413 1.00 30.39 ? 390 TYR B CB 1 ATOM 4984 C CG . TYR B 1 324 ? 37.753 80.949 75.276 1.00 31.18 ? 390 TYR B CG 1 ATOM 4985 C CD1 . TYR B 1 324 ? 36.899 82.036 75.467 1.00 33.15 ? 390 TYR B CD1 1 ATOM 4986 C CD2 . TYR B 1 324 ? 37.825 80.389 74.004 1.00 30.71 ? 390 TYR B CD2 1 ATOM 4987 C CE1 . TYR B 1 324 ? 36.143 82.553 74.415 1.00 33.05 ? 390 TYR B CE1 1 ATOM 4988 C CE2 . TYR B 1 324 ? 37.047 80.870 72.958 1.00 30.57 ? 390 TYR B CE2 1 ATOM 4989 C CZ . TYR B 1 324 ? 36.234 81.970 73.155 1.00 33.86 ? 390 TYR B CZ 1 ATOM 4990 O OH . TYR B 1 324 ? 35.529 82.444 72.072 1.00 28.07 ? 390 TYR B OH 1 ATOM 4991 N N . THR B 1 325 ? 39.997 83.604 76.390 1.00 31.65 ? 391 THR B N 1 ATOM 4992 C CA . THR B 1 325 ? 39.967 85.002 76.845 1.00 30.44 ? 391 THR B CA 1 ATOM 4993 C C . THR B 1 325 ? 38.916 85.843 76.137 1.00 33.84 ? 391 THR B C 1 ATOM 4994 O O . THR B 1 325 ? 38.834 85.847 74.910 1.00 32.40 ? 391 THR B O 1 ATOM 4995 C CB . THR B 1 325 ? 41.390 85.621 76.720 1.00 33.18 ? 391 THR B CB 1 ATOM 4996 O OG1 . THR B 1 325 ? 42.331 84.756 77.328 1.00 32.24 ? 391 THR B OG1 1 ATOM 4997 C CG2 . THR B 1 325 ? 41.509 86.991 77.336 1.00 28.74 ? 391 THR B CG2 1 ATOM 4998 N N . GLU B 1 326 ? 38.135 86.575 76.928 1.00 32.27 ? 392 GLU B N 1 ATOM 4999 C CA . GLU B 1 326 ? 37.117 87.496 76.447 1.00 32.28 ? 392 GLU B CA 1 ATOM 5000 C C . GLU B 1 326 ? 37.508 88.926 76.864 1.00 35.16 ? 392 GLU B C 1 ATOM 5001 O O . GLU B 1 326 ? 37.704 89.216 78.047 1.00 34.39 ? 392 GLU B O 1 ATOM 5002 C CB . GLU B 1 326 ? 35.719 87.094 76.950 1.00 33.82 ? 392 GLU B CB 1 ATOM 5003 C CG . GLU B 1 326 ? 34.617 88.032 76.512 1.00 40.89 ? 392 GLU B CG 1 ATOM 5004 C CD . GLU B 1 326 ? 33.268 87.743 77.128 1.00 44.53 ? 392 GLU B CD 1 ATOM 5005 O OE1 . GLU B 1 326 ? 32.571 86.810 76.672 1.00 53.94 ? 392 GLU B OE1 1 ATOM 5006 O OE2 . GLU B 1 326 ? 32.919 88.441 78.103 1.00 39.17 ? 392 GLU B OE2 1 ATOM 5007 N N . PHE B 1 327 ? 37.652 89.803 75.870 1.00 32.23 ? 393 PHE B N 1 ATOM 5008 C CA . PHE B 1 327 ? 38.005 91.215 76.052 1.00 30.54 ? 393 PHE B CA 1 ATOM 5009 C C . PHE B 1 327 ? 36.725 91.999 75.975 1.00 35.24 ? 393 PHE B C 1 ATOM 5010 O O . PHE B 1 327 ? 36.079 92.029 74.931 1.00 34.15 ? 393 PHE B O 1 ATOM 5011 C CB . PHE B 1 327 ? 39.000 91.646 74.983 1.00 30.34 ? 393 PHE B CB 1 ATOM 5012 C CG . PHE B 1 327 ? 40.319 90.926 75.099 1.00 29.23 ? 393 PHE B CG 1 ATOM 5013 C CD1 . PHE B 1 327 ? 41.338 91.435 75.903 1.00 29.35 ? 393 PHE B CD1 1 ATOM 5014 C CD2 . PHE B 1 327 ? 40.554 89.752 74.391 1.00 29.81 ? 393 PHE B CD2 1 ATOM 5015 C CE1 . PHE B 1 327 ? 42.565 90.769 76.016 1.00 29.33 ? 393 PHE B CE1 1 ATOM 5016 C CE2 . PHE B 1 327 ? 41.791 89.092 74.488 1.00 32.37 ? 393 PHE B CE2 1 ATOM 5017 C CZ . PHE B 1 327 ? 42.789 89.608 75.301 1.00 29.72 ? 393 PHE B CZ 1 ATOM 5018 N N . ASP B 1 328 ? 36.298 92.533 77.128 1.00 34.93 ? 394 ASP B N 1 ATOM 5019 C CA . ASP B 1 328 ? 35.012 93.221 77.295 1.00 34.46 ? 394 ASP B CA 1 ATOM 5020 C C . ASP B 1 328 ? 35.192 94.730 77.332 1.00 37.87 ? 394 ASP B C 1 ATOM 5021 O O . ASP B 1 328 ? 35.649 95.290 78.334 1.00 38.93 ? 394 ASP B O 1 ATOM 5022 C CB . ASP B 1 328 ? 34.326 92.668 78.561 1.00 35.21 ? 394 ASP B CB 1 ATOM 5023 C CG . ASP B 1 328 ? 32.933 93.156 78.915 1.00 38.61 ? 394 ASP B CG 1 ATOM 5024 O OD1 . ASP B 1 328 ? 32.431 94.068 78.236 1.00 39.07 ? 394 ASP B OD1 1 ATOM 5025 O OD2 . ASP B 1 328 ? 32.363 92.647 79.904 1.00 35.67 ? 394 ASP B OD2 1 ATOM 5026 N N . ARG B 1 329 ? 34.829 95.391 76.233 1.00 34.38 ? 395 ARG B N 1 ATOM 5027 C CA . ARG B 1 329 ? 34.947 96.850 76.112 1.00 34.81 ? 395 ARG B CA 1 ATOM 5028 C C . ARG B 1 329 ? 33.881 97.609 76.907 1.00 37.85 ? 395 ARG B C 1 ATOM 5029 O O . ARG B 1 329 ? 34.191 98.625 77.522 1.00 39.49 ? 395 ARG B O 1 ATOM 5030 C CB . ARG B 1 329 ? 34.914 97.275 74.635 1.00 35.49 ? 395 ARG B CB 1 ATOM 5031 C CG . ARG B 1 329 ? 36.213 97.030 73.857 1.00 38.49 ? 395 ARG B CG 1 ATOM 5032 C CD . ARG B 1 329 ? 37.329 97.990 74.239 1.00 43.96 ? 395 ARG B CD 1 ATOM 5033 N NE . ARG B 1 329 ? 36.929 99.395 74.167 1.00 62.35 ? 395 ARG B NE 1 ATOM 5034 C CZ . ARG B 1 329 ? 37.041 100.146 73.079 1.00 75.69 ? 395 ARG B CZ 1 ATOM 5035 N NH1 . ARG B 1 329 ? 37.537 99.632 71.955 1.00 51.40 ? 395 ARG B NH1 1 ATOM 5036 N NH2 . ARG B 1 329 ? 36.657 101.418 73.103 1.00 62.41 ? 395 ARG B NH2 1 ATOM 5037 N N . ARG B 1 330 ? 32.641 97.115 76.896 1.00 33.29 ? 396 ARG B N 1 ATOM 5038 C CA . ARG B 1 330 ? 31.500 97.725 77.595 1.00 34.10 ? 396 ARG B CA 1 ATOM 5039 C C . ARG B 1 330 ? 31.780 97.976 79.084 1.00 37.98 ? 396 ARG B C 1 ATOM 5040 O O . ARG B 1 330 ? 31.517 99.082 79.582 1.00 37.87 ? 396 ARG B O 1 ATOM 5041 C CB . ARG B 1 330 ? 30.213 96.876 77.378 1.00 33.67 ? 396 ARG B CB 1 ATOM 5042 C CG . ARG B 1 330 ? 28.918 97.334 78.090 1.00 41.09 ? 396 ARG B CG 1 ATOM 5043 C CD . ARG B 1 330 ? 28.468 98.780 77.862 1.00 40.65 ? 396 ARG B CD 1 ATOM 5044 N NE . ARG B 1 330 ? 27.382 99.137 78.788 1.00 34.15 ? 396 ARG B NE 1 ATOM 5045 C CZ . ARG B 1 330 ? 27.569 99.656 79.998 1.00 38.34 ? 396 ARG B CZ 1 ATOM 5046 N NH1 . ARG B 1 330 ? 28.796 99.904 80.441 1.00 30.89 ? 396 ARG B NH1 1 ATOM 5047 N NH2 . ARG B 1 330 ? 26.535 99.943 80.766 1.00 30.04 ? 396 ARG B NH2 1 ATOM 5048 N N . ASN B 1 331 ? 32.407 96.977 79.747 1.00 32.94 ? 397 ASN B N 1 ATOM 5049 C CA . ASN B 1 331 ? 32.700 96.972 81.165 1.00 31.95 ? 397 ASN B CA 1 ATOM 5050 C C . ASN B 1 331 ? 34.171 97.155 81.562 1.00 37.89 ? 397 ASN B C 1 ATOM 5051 O O . ASN B 1 331 ? 34.472 97.121 82.755 1.00 38.33 ? 397 ASN B O 1 ATOM 5052 C CB . ASN B 1 331 ? 32.159 95.678 81.768 1.00 30.19 ? 397 ASN B CB 1 ATOM 5053 C CG . ASN B 1 331 ? 30.680 95.540 81.648 1.00 41.18 ? 397 ASN B CG 1 ATOM 5054 O OD1 . ASN B 1 331 ? 29.931 96.463 81.956 1.00 41.36 ? 397 ASN B OD1 1 ATOM 5055 N ND2 . ASN B 1 331 ? 30.230 94.396 81.172 1.00 30.82 ? 397 ASN B ND2 1 ATOM 5056 N N . ASN B 1 332 ? 35.082 97.347 80.595 1.00 35.58 ? 398 ASN B N 1 ATOM 5057 C CA . ASN B 1 332 ? 36.529 97.495 80.825 1.00 35.21 ? 398 ASN B CA 1 ATOM 5058 C C . ASN B 1 332 ? 37.068 96.408 81.739 1.00 38.63 ? 398 ASN B C 1 ATOM 5059 O O . ASN B 1 332 ? 37.670 96.673 82.787 1.00 38.71 ? 398 ASN B O 1 ATOM 5060 C CB . ASN B 1 332 ? 36.918 98.899 81.292 1.00 37.10 ? 398 ASN B CB 1 ATOM 5061 C CG . ASN B 1 332 ? 36.639 99.947 80.260 1.00 55.75 ? 398 ASN B CG 1 ATOM 5062 O OD1 . ASN B 1 332 ? 37.418 100.180 79.328 1.00 51.38 ? 398 ASN B OD1 1 ATOM 5063 N ND2 . ASN B 1 332 ? 35.577 100.678 80.499 1.00 45.52 ? 398 ASN B ND2 1 ATOM 5064 N N . ARG B 1 333 ? 36.840 95.157 81.319 1.00 33.54 ? 399 ARG B N 1 ATOM 5065 C CA . ARG B 1 333 ? 37.269 93.967 82.042 1.00 31.90 ? 399 ARG B CA 1 ATOM 5066 C C . ARG B 1 333 ? 37.690 92.871 81.069 1.00 34.67 ? 399 ARG B C 1 ATOM 5067 O O . ARG B 1 333 ? 37.367 92.937 79.888 1.00 33.19 ? 399 ARG B O 1 ATOM 5068 C CB . ARG B 1 333 ? 36.156 93.461 83.003 1.00 27.69 ? 399 ARG B CB 1 ATOM 5069 C CG . ARG B 1 333 ? 34.854 93.109 82.308 1.00 28.74 ? 399 ARG B CG 1 ATOM 5070 C CD . ARG B 1 333 ? 33.831 92.634 83.299 1.00 33.29 ? 399 ARG B CD 1 ATOM 5071 N NE . ARG B 1 333 ? 32.694 92.017 82.633 1.00 32.14 ? 399 ARG B NE 1 ATOM 5072 C CZ . ARG B 1 333 ? 31.734 91.356 83.264 1.00 38.07 ? 399 ARG B CZ 1 ATOM 5073 N NH1 . ARG B 1 333 ? 31.766 91.226 84.581 1.00 29.76 ? 399 ARG B NH1 1 ATOM 5074 N NH2 . ARG B 1 333 ? 30.722 90.836 82.585 1.00 23.69 ? 399 ARG B NH2 1 ATOM 5075 N N . ILE B 1 334 ? 38.387 91.849 81.590 1.00 31.27 ? 400 ILE B N 1 ATOM 5076 C CA . ILE B 1 334 ? 38.856 90.686 80.846 1.00 29.86 ? 400 ILE B CA 1 ATOM 5077 C C . ILE B 1 334 ? 38.314 89.439 81.541 1.00 34.89 ? 400 ILE B C 1 ATOM 5078 O O . ILE B 1 334 ? 38.429 89.308 82.750 1.00 34.35 ? 400 ILE B O 1 ATOM 5079 C CB . ILE B 1 334 ? 40.407 90.670 80.707 1.00 31.89 ? 400 ILE B CB 1 ATOM 5080 C CG1 . ILE B 1 334 ? 40.908 91.895 79.885 1.00 31.55 ? 400 ILE B CG1 1 ATOM 5081 C CG2 . ILE B 1 334 ? 40.890 89.334 80.085 1.00 31.51 ? 400 ILE B CG2 1 ATOM 5082 C CD1 . ILE B 1 334 ? 42.422 92.205 79.908 1.00 26.86 ? 400 ILE B CD1 1 ATOM 5083 N N . GLY B 1 335 ? 37.730 88.543 80.770 1.00 32.37 ? 401 GLY B N 1 ATOM 5084 C CA . GLY B 1 335 ? 37.225 87.288 81.285 1.00 32.87 ? 401 GLY B CA 1 ATOM 5085 C C . GLY B 1 335 ? 38.077 86.105 80.872 1.00 38.53 ? 401 GLY B C 1 ATOM 5086 O O . GLY B 1 335 ? 38.572 86.032 79.742 1.00 38.10 ? 401 GLY B O 1 ATOM 5087 N N . PHE B 1 336 ? 38.227 85.166 81.782 1.00 34.81 ? 402 PHE B N 1 ATOM 5088 C CA . PHE B 1 336 ? 38.950 83.936 81.525 1.00 34.33 ? 402 PHE B CA 1 ATOM 5089 C C . PHE B 1 336 ? 38.078 82.714 81.859 1.00 37.99 ? 402 PHE B C 1 ATOM 5090 O O . PHE B 1 336 ? 37.341 82.695 82.853 1.00 38.81 ? 402 PHE B O 1 ATOM 5091 C CB . PHE B 1 336 ? 40.253 83.888 82.333 1.00 34.91 ? 402 PHE B CB 1 ATOM 5092 C CG . PHE B 1 336 ? 41.304 84.922 82.012 1.00 35.55 ? 402 PHE B CG 1 ATOM 5093 C CD1 . PHE B 1 336 ? 41.902 84.972 80.753 1.00 36.71 ? 402 PHE B CD1 1 ATOM 5094 C CD2 . PHE B 1 336 ? 41.767 85.794 82.995 1.00 37.28 ? 402 PHE B CD2 1 ATOM 5095 C CE1 . PHE B 1 336 ? 42.904 85.921 80.470 1.00 37.29 ? 402 PHE B CE1 1 ATOM 5096 C CE2 . PHE B 1 336 ? 42.787 86.723 82.721 1.00 38.71 ? 402 PHE B CE2 1 ATOM 5097 C CZ . PHE B 1 336 ? 43.336 86.790 81.457 1.00 36.33 ? 402 PHE B CZ 1 ATOM 5098 N N . ALA B 1 337 ? 38.169 81.702 81.010 1.00 33.46 ? 403 ALA B N 1 ATOM 5099 C CA . ALA B 1 337 ? 37.481 80.419 81.164 1.00 32.67 ? 403 ALA B CA 1 ATOM 5100 C C . ALA B 1 337 ? 38.460 79.374 80.657 1.00 38.73 ? 403 ALA B C 1 ATOM 5101 O O . ALA B 1 337 ? 39.321 79.695 79.836 1.00 38.43 ? 403 ALA B O 1 ATOM 5102 C CB . ALA B 1 337 ? 36.193 80.378 80.364 1.00 32.22 ? 403 ALA B CB 1 ATOM 5103 N N . LEU B 1 338 ? 38.377 78.146 81.187 1.00 35.37 ? 404 LEU B N 1 ATOM 5104 C CA . LEU B 1 338 ? 39.269 77.059 80.802 1.00 35.12 ? 404 LEU B CA 1 ATOM 5105 C C . LEU B 1 338 ? 39.017 76.641 79.342 1.00 38.45 ? 404 LEU B C 1 ATOM 5106 O O . LEU B 1 338 ? 37.897 76.277 78.985 1.00 36.58 ? 404 LEU B O 1 ATOM 5107 C CB . LEU B 1 338 ? 39.131 75.869 81.777 1.00 35.20 ? 404 LEU B CB 1 ATOM 5108 C CG . LEU B 1 338 ? 40.086 74.686 81.545 1.00 40.50 ? 404 LEU B CG 1 ATOM 5109 C CD1 . LEU B 1 338 ? 41.496 75.086 81.829 1.00 39.91 ? 404 LEU B CD1 1 ATOM 5110 C CD2 . LEU B 1 338 ? 39.700 73.471 82.406 1.00 43.56 ? 404 LEU B CD2 1 ATOM 5111 N N . ALA B 1 339 ? 40.079 76.734 78.504 1.00 36.50 ? 405 ALA B N 1 ATOM 5112 C CA . ALA B 1 339 ? 40.029 76.403 77.077 1.00 36.41 ? 405 ALA B CA 1 ATOM 5113 C C . ALA B 1 339 ? 39.854 74.905 76.805 1.00 40.15 ? 405 ALA B C 1 ATOM 5114 O O . ALA B 1 339 ? 40.386 74.068 77.546 1.00 39.56 ? 405 ALA B O 1 ATOM 5115 C CB . ALA B 1 339 ? 41.276 76.909 76.390 1.00 36.86 ? 405 ALA B CB 1 ATOM 5116 N N . ARG B 1 340 ? 39.096 74.565 75.754 1.00 35.92 ? 406 ARG B N 1 ATOM 5117 C CA . ARG B 1 340 ? 38.900 73.163 75.354 1.00 35.78 ? 406 ARG B CA 1 ATOM 5118 C C . ARG B 1 340 ? 38.922 72.993 73.824 1.00 48.77 ? 406 ARG B C 1 ATOM 5119 O O . ARG B 1 340 ? 39.359 71.909 73.392 1.00 61.00 ? 406 ARG B O 1 ATOM 5120 C CB . ARG B 1 340 ? 37.652 72.524 76.008 1.00 32.57 ? 406 ARG B CB 1 ATOM 5121 C CG . ARG B 1 340 ? 36.341 72.988 75.411 1.00 38.27 ? 406 ARG B CG 1 ATOM 5122 C CD . ARG B 1 340 ? 35.182 72.352 76.108 1.00 46.27 ? 406 ARG B CD 1 ATOM 5123 N NE . ARG B 1 340 ? 33.943 72.700 75.430 1.00 57.71 ? 406 ARG B NE 1 ATOM 5124 C CZ . ARG B 1 340 ? 32.743 72.291 75.801 1.00 81.80 ? 406 ARG B CZ 1 ATOM 5125 N NH1 . ARG B 1 340 ? 32.599 71.514 76.871 1.00 80.52 ? 406 ARG B NH1 1 ATOM 5126 N NH2 . ARG B 1 340 ? 31.672 72.658 75.110 1.00 70.00 ? 406 ARG B NH2 1 ATOM 5127 O OXT . ARG B 1 340 ? 38.555 73.936 73.068 1.00 56.77 ? 406 ARG B OXT 1 HETATM 5128 C C1 . NAG C 2 . ? 13.292 47.240 37.398 1.00 55.83 ? 501 NAG A C1 1 HETATM 5129 C C2 . NAG C 2 . ? 12.244 46.394 36.669 1.00 55.84 ? 501 NAG A C2 1 HETATM 5130 C C3 . NAG C 2 . ? 11.895 47.106 35.361 1.00 63.71 ? 501 NAG A C3 1 HETATM 5131 C C4 . NAG C 2 . ? 11.393 48.521 35.647 1.00 68.67 ? 501 NAG A C4 1 HETATM 5132 C C5 . NAG C 2 . ? 12.458 49.317 36.402 1.00 67.28 ? 501 NAG A C5 1 HETATM 5133 C C6 . NAG C 2 . ? 11.981 50.679 36.858 1.00 70.02 ? 501 NAG A C6 1 HETATM 5134 C C7 . NAG C 2 . ? 12.198 43.960 37.121 1.00 47.01 ? 501 NAG A C7 1 HETATM 5135 C C8 . NAG C 2 . ? 12.631 42.615 36.626 1.00 43.05 ? 501 NAG A C8 1 HETATM 5136 N N2 . NAG C 2 . ? 12.650 45.020 36.415 1.00 49.19 ? 501 NAG A N2 1 HETATM 5137 O O3 . NAG C 2 . ? 10.904 46.368 34.652 1.00 65.07 ? 501 NAG A O3 1 HETATM 5138 O O4 . NAG C 2 . ? 11.067 49.186 34.430 1.00 74.05 ? 501 NAG A O4 1 HETATM 5139 O O5 . NAG C 2 . ? 12.866 48.603 37.586 1.00 61.12 ? 501 NAG A O5 1 HETATM 5140 O O6 . NAG C 2 . ? 11.607 51.505 35.761 1.00 72.83 ? 501 NAG A O6 1 HETATM 5141 O O7 . NAG C 2 . ? 11.476 44.084 38.111 1.00 49.83 ? 501 NAG A O7 1 HETATM 5142 C C25 . 70Y D 3 . ? 37.334 57.010 46.951 1.00 41.59 ? 502 70Y A C25 1 HETATM 5143 C C26 . 70Y D 3 . ? 37.506 55.645 46.847 1.00 37.47 ? 502 70Y A C26 1 HETATM 5144 C C27 . 70Y D 3 . ? 38.197 54.975 47.832 1.00 37.12 ? 502 70Y A C27 1 HETATM 5145 C C28 . 70Y D 3 . ? 38.727 55.668 48.898 1.00 38.88 ? 502 70Y A C28 1 HETATM 5146 C C31 . 70Y D 3 . ? 34.049 57.461 45.439 1.00 50.77 ? 502 70Y A C31 1 HETATM 5147 C C29 . 70Y D 3 . ? 38.537 57.031 48.999 1.00 41.17 ? 502 70Y A C29 1 HETATM 5148 C C24 . 70Y D 3 . ? 37.833 57.725 48.030 1.00 44.96 ? 502 70Y A C24 1 HETATM 5149 C C23 . 70Y D 3 . ? 36.993 59.919 46.992 1.00 53.61 ? 502 70Y A C23 1 HETATM 5150 C C22 . 70Y D 3 . ? 37.634 59.218 48.183 1.00 51.77 ? 502 70Y A C22 1 HETATM 5151 C C20 . 70Y D 3 . ? 39.302 60.373 46.961 1.00 59.67 ? 502 70Y A C20 1 HETATM 5152 C C4 . 70Y D 3 . ? 34.625 59.897 42.215 1.00 59.30 ? 502 70Y A C4 1 HETATM 5153 C C2 . 70Y D 3 . ? 32.847 59.258 43.980 1.00 53.24 ? 502 70Y A C2 1 HETATM 5154 C C3 . 70Y D 3 . ? 33.626 58.888 42.728 1.00 57.10 ? 502 70Y A C3 1 HETATM 5155 C C11 . 70Y D 3 . ? 31.541 58.504 43.870 1.00 52.76 ? 502 70Y A C11 1 HETATM 5156 C C17 . 70Y D 3 . ? 38.899 62.850 43.552 1.00 64.44 ? 502 70Y A C17 1 HETATM 5157 C C16 . 70Y D 3 . ? 38.987 62.119 44.714 1.00 60.89 ? 502 70Y A C16 1 HETATM 5158 C C15 . 70Y D 3 . ? 37.925 61.344 45.144 1.00 58.13 ? 502 70Y A C15 1 HETATM 5159 C C14 . 70Y D 3 . ? 36.746 61.346 44.406 1.00 58.37 ? 502 70Y A C14 1 HETATM 5160 C C12 . 70Y D 3 . ? 32.986 59.386 46.572 1.00 43.45 ? 502 70Y A C12 1 HETATM 5161 N N1 . 70Y D 3 . ? 32.498 60.668 43.914 1.00 56.69 ? 502 70Y A N1 1 HETATM 5162 N N5 . 70Y D 3 . ? 34.391 61.204 42.604 1.00 59.28 ? 502 70Y A N5 1 HETATM 5163 C C6 . 70Y D 3 . ? 33.141 61.569 43.089 1.00 58.26 ? 502 70Y A C6 1 HETATM 5164 N N7 . 70Y D 3 . ? 32.619 62.698 42.740 1.00 57.54 ? 502 70Y A N7 1 HETATM 5165 O O8 . 70Y D 3 . ? 35.552 59.531 41.505 1.00 60.79 ? 502 70Y A O8 1 HETATM 5166 C C9 . 70Y D 3 . ? 35.417 62.196 42.383 1.00 58.68 ? 502 70Y A C9 1 HETATM 5167 C C10 . 70Y D 3 . ? 33.623 58.922 45.276 1.00 49.77 ? 502 70Y A C10 1 HETATM 5168 C C13 . 70Y D 3 . ? 36.639 62.096 43.242 1.00 59.90 ? 502 70Y A C13 1 HETATM 5169 C C18 . 70Y D 3 . ? 37.728 62.828 42.819 1.00 63.30 ? 502 70Y A C18 1 HETATM 5170 N N19 . 70Y D 3 . ? 38.081 60.613 46.351 1.00 56.40 ? 502 70Y A N19 1 HETATM 5171 C C21 . 70Y D 3 . ? 38.992 59.860 48.327 1.00 57.12 ? 502 70Y A C21 1 HETATM 5172 O O30 . 70Y D 3 . ? 40.451 60.477 46.532 1.00 62.31 ? 502 70Y A O30 1 HETATM 5173 C C25 . 70Y E 3 . ? 57.255 89.154 66.296 1.00 73.81 ? 501 70Y B C25 1 HETATM 5174 C C26 . 70Y E 3 . ? 57.787 89.729 65.163 1.00 72.91 ? 501 70Y B C26 1 HETATM 5175 C C27 . 70Y E 3 . ? 57.957 88.965 64.026 1.00 71.68 ? 501 70Y B C27 1 HETATM 5176 C C28 . 70Y E 3 . ? 57.606 87.633 64.023 1.00 70.00 ? 501 70Y B C28 1 HETATM 5177 C C31 . 70Y E 3 . ? 54.688 91.676 66.274 1.00 63.67 ? 501 70Y B C31 1 HETATM 5178 C C29 . 70Y E 3 . ? 57.062 87.070 65.154 1.00 70.68 ? 501 70Y B C29 1 HETATM 5179 C C24 . 70Y E 3 . ? 56.871 87.822 66.298 1.00 75.43 ? 501 70Y B C24 1 HETATM 5180 C C23 . 70Y E 3 . ? 55.604 88.088 68.497 1.00 83.00 ? 501 70Y B C23 1 HETATM 5181 C C22 . 70Y E 3 . ? 56.285 87.145 67.513 1.00 81.62 ? 501 70Y B C22 1 HETATM 5182 C C20 . 70Y E 3 . ? 57.716 87.456 69.378 1.00 85.84 ? 501 70Y B C20 1 HETATM 5183 C C4 . 70Y E 3 . ? 55.117 93.270 69.890 1.00 77.81 ? 501 70Y B C4 1 HETATM 5184 C C2 . 70Y E 3 . ? 53.345 92.992 68.045 1.00 70.46 ? 501 70Y B C2 1 HETATM 5185 C C3 . 70Y E 3 . ? 54.587 93.720 68.553 1.00 74.48 ? 501 70Y B C3 1 HETATM 5186 C C11 . 70Y E 3 . ? 52.672 93.970 67.095 1.00 68.98 ? 501 70Y B C11 1 HETATM 5187 C C17 . 70Y E 3 . ? 56.711 89.203 73.097 1.00 87.91 ? 501 70Y B C17 1 HETATM 5188 C C16 . 70Y E 3 . ? 56.884 88.487 71.933 1.00 86.41 ? 501 70Y B C16 1 HETATM 5189 C C15 . 70Y E 3 . ? 56.344 88.954 70.748 1.00 86.44 ? 501 70Y B C15 1 HETATM 5190 C C14 . 70Y E 3 . ? 55.613 90.135 70.747 1.00 86.62 ? 501 70Y B C14 1 HETATM 5191 C C12 . 70Y E 3 . ? 52.423 90.905 66.849 1.00 57.97 ? 501 70Y B C12 1 HETATM 5192 N N1 . 70Y E 3 . ? 52.430 92.771 69.161 1.00 73.22 ? 501 70Y B N1 1 HETATM 5193 N N5 . 70Y E 3 . ? 54.179 92.702 70.750 1.00 79.01 ? 501 70Y B N5 1 HETATM 5194 C C6 . 70Y E 3 . ? 52.820 92.814 70.478 1.00 74.34 ? 501 70Y B C6 1 HETATM 5195 N N7 . 70Y E 3 . ? 51.971 92.983 71.433 1.00 71.55 ? 501 70Y B N7 1 HETATM 5196 O O8 . 70Y E 3 . ? 56.306 93.419 70.147 1.00 77.87 ? 501 70Y B O8 1 HETATM 5197 C C9 . 70Y E 3 . ? 54.641 92.138 72.009 1.00 81.40 ? 501 70Y B C9 1 HETATM 5198 C C10 . 70Y E 3 . ? 53.644 91.636 67.375 1.00 63.73 ? 501 70Y B C10 1 HETATM 5199 C C13 . 70Y E 3 . ? 55.431 90.865 71.916 1.00 85.34 ? 501 70Y B C13 1 HETATM 5200 C C18 . 70Y E 3 . ? 55.999 90.388 73.081 1.00 87.79 ? 501 70Y B C18 1 HETATM 5201 N N19 . 70Y E 3 . ? 56.571 88.209 69.565 1.00 85.63 ? 501 70Y B N19 1 HETATM 5202 C C21 . 70Y E 3 . ? 57.435 86.498 68.267 1.00 84.12 ? 501 70Y B C21 1 HETATM 5203 O O30 . 70Y E 3 . ? 58.796 87.523 69.958 1.00 86.22 ? 501 70Y B O30 1 HETATM 5204 O O . HOH F 4 . ? 35.985 53.945 35.881 1.00 36.45 ? 601 HOH A O 1 HETATM 5205 O O . HOH F 4 . ? 15.928 38.787 45.318 1.00 44.38 ? 602 HOH A O 1 HETATM 5206 O O . HOH F 4 . ? 38.565 49.896 54.213 1.00 33.66 ? 603 HOH A O 1 HETATM 5207 O O . HOH F 4 . ? 39.264 38.371 50.358 1.00 27.72 ? 604 HOH A O 1 HETATM 5208 O O . HOH F 4 . ? 10.951 41.880 39.908 1.00 41.58 ? 605 HOH A O 1 HETATM 5209 O O . HOH F 4 . ? 8.455 43.139 50.466 1.00 36.50 ? 606 HOH A O 1 HETATM 5210 O O . HOH F 4 . ? 33.850 33.565 46.560 1.00 54.04 ? 607 HOH A O 1 HETATM 5211 O O . HOH F 4 . ? 40.460 61.304 60.772 1.00 37.50 ? 608 HOH A O 1 HETATM 5212 O O . HOH F 4 . ? 20.904 37.098 50.626 1.00 58.44 ? 609 HOH A O 1 HETATM 5213 O O . HOH F 4 . ? 36.985 49.246 56.307 1.00 34.79 ? 610 HOH A O 1 HETATM 5214 O O . HOH F 4 . ? 34.045 48.970 32.649 1.00 38.91 ? 611 HOH A O 1 HETATM 5215 O O . HOH F 4 . ? 11.411 46.498 40.732 1.00 46.58 ? 612 HOH A O 1 HETATM 5216 O O . HOH F 4 . ? 40.001 41.701 46.049 1.00 35.63 ? 613 HOH A O 1 HETATM 5217 O O . HOH F 4 . ? 42.068 46.147 42.721 1.00 42.37 ? 614 HOH A O 1 HETATM 5218 O O . HOH F 4 . ? 32.658 41.993 35.267 1.00 56.51 ? 615 HOH A O 1 HETATM 5219 O O . HOH F 4 . ? 33.618 37.197 54.656 1.00 43.70 ? 616 HOH A O 1 HETATM 5220 O O . HOH F 4 . ? 37.184 38.157 42.318 1.00 47.78 ? 617 HOH A O 1 HETATM 5221 O O . HOH F 4 . ? 43.972 43.976 43.976 0.33 46.41 ? 618 HOH A O 1 HETATM 5222 O O . HOH F 4 . ? 33.601 51.511 50.243 1.00 35.22 ? 619 HOH A O 1 HETATM 5223 O O . HOH F 4 . ? 39.837 43.270 43.814 1.00 31.74 ? 620 HOH A O 1 HETATM 5224 O O . HOH F 4 . ? 31.574 42.106 55.376 1.00 39.74 ? 621 HOH A O 1 HETATM 5225 O O . HOH F 4 . ? 49.898 85.504 47.798 1.00 33.34 ? 622 HOH A O 1 HETATM 5226 O O . HOH F 4 . ? 34.474 63.826 62.734 1.00 30.01 ? 623 HOH A O 1 HETATM 5227 O O . HOH F 4 . ? 37.770 84.635 49.616 1.00 48.81 ? 624 HOH A O 1 HETATM 5228 O O . HOH F 4 . ? 51.472 66.241 54.182 1.00 38.71 ? 625 HOH A O 1 HETATM 5229 O O . HOH F 4 . ? 27.093 54.454 60.595 1.00 54.66 ? 626 HOH A O 1 HETATM 5230 O O . HOH F 4 . ? 13.318 54.680 40.083 1.00 47.85 ? 627 HOH A O 1 HETATM 5231 O O . HOH F 4 . ? 16.943 44.314 57.410 1.00 34.40 ? 628 HOH A O 1 HETATM 5232 O O . HOH F 4 . ? 16.928 42.893 43.378 1.00 29.67 ? 629 HOH A O 1 HETATM 5233 O O . HOH F 4 . ? 31.942 74.104 55.111 1.00 30.19 ? 630 HOH A O 1 HETATM 5234 O O . HOH F 4 . ? 21.336 41.137 49.484 1.00 32.94 ? 631 HOH A O 1 HETATM 5235 O O . HOH F 4 . ? 26.602 57.380 42.631 1.00 36.28 ? 632 HOH A O 1 HETATM 5236 O O . HOH F 4 . ? 37.858 44.022 46.981 1.00 35.79 ? 633 HOH A O 1 HETATM 5237 O O . HOH F 4 . ? 19.119 41.067 46.461 1.00 28.88 ? 634 HOH A O 1 HETATM 5238 O O . HOH F 4 . ? 19.843 66.926 43.209 1.00 37.30 ? 635 HOH A O 1 HETATM 5239 O O . HOH F 4 . ? 41.205 67.340 51.321 1.00 38.69 ? 636 HOH A O 1 HETATM 5240 O O . HOH F 4 . ? 41.173 59.091 51.211 1.00 31.13 ? 637 HOH A O 1 HETATM 5241 O O . HOH F 4 . ? 29.381 63.426 52.414 1.00 31.68 ? 638 HOH A O 1 HETATM 5242 O O . HOH F 4 . ? 25.055 72.276 56.912 1.00 29.38 ? 639 HOH A O 1 HETATM 5243 O O . HOH F 4 . ? 30.737 38.892 43.425 1.00 36.70 ? 640 HOH A O 1 HETATM 5244 O O . HOH F 4 . ? 27.879 42.978 56.886 1.00 33.69 ? 641 HOH A O 1 HETATM 5245 O O . HOH F 4 . ? 19.961 55.124 42.879 1.00 28.22 ? 642 HOH A O 1 HETATM 5246 O O . HOH F 4 . ? 20.670 59.314 44.218 1.00 37.37 ? 643 HOH A O 1 HETATM 5247 O O . HOH F 4 . ? 23.617 44.617 56.758 1.00 38.06 ? 644 HOH A O 1 HETATM 5248 O O . HOH F 4 . ? 19.624 57.267 41.050 1.00 37.01 ? 645 HOH A O 1 HETATM 5249 O O . HOH F 4 . ? 19.854 62.912 44.898 1.00 32.90 ? 646 HOH A O 1 HETATM 5250 O O . HOH F 4 . ? 39.720 68.227 37.214 1.00 37.64 ? 647 HOH A O 1 HETATM 5251 O O . HOH F 4 . ? 21.522 53.288 41.680 1.00 36.44 ? 648 HOH A O 1 HETATM 5252 O O . HOH F 4 . ? 25.812 83.539 37.288 1.00 43.19 ? 649 HOH A O 1 HETATM 5253 O O . HOH F 4 . ? 35.777 79.374 56.368 1.00 40.87 ? 650 HOH A O 1 HETATM 5254 O O . HOH F 4 . ? 18.854 57.302 59.235 1.00 50.50 ? 651 HOH A O 1 HETATM 5255 O O . HOH F 4 . ? 8.646 57.681 49.522 1.00 36.65 ? 652 HOH A O 1 HETATM 5256 O O . HOH F 4 . ? 48.557 66.735 45.379 1.00 37.29 ? 653 HOH A O 1 HETATM 5257 O O . HOH F 4 . ? 19.285 45.391 60.894 1.00 33.51 ? 654 HOH A O 1 HETATM 5258 O O . HOH F 4 . ? 33.913 62.935 51.087 1.00 44.11 ? 655 HOH A O 1 HETATM 5259 O O . HOH F 4 . ? 39.387 67.814 33.301 1.00 34.38 ? 656 HOH A O 1 HETATM 5260 O O . HOH F 4 . ? 37.690 73.610 32.036 1.00 45.89 ? 657 HOH A O 1 HETATM 5261 O O . HOH F 4 . ? 20.436 59.400 58.700 1.00 34.54 ? 658 HOH A O 1 HETATM 5262 O O . HOH F 4 . ? 24.886 60.434 60.157 1.00 39.04 ? 659 HOH A O 1 HETATM 5263 O O . HOH F 4 . ? 28.273 57.244 60.303 1.00 39.68 ? 660 HOH A O 1 HETATM 5264 O O . HOH F 4 . ? 38.198 80.901 57.020 1.00 42.67 ? 661 HOH A O 1 HETATM 5265 O O . HOH F 4 . ? 34.896 81.804 59.679 1.00 48.19 ? 662 HOH A O 1 HETATM 5266 O O . HOH F 4 . ? 25.788 58.748 38.729 1.00 38.43 ? 663 HOH A O 1 HETATM 5267 O O . HOH F 4 . ? 29.617 84.969 53.182 1.00 41.33 ? 664 HOH A O 1 HETATM 5268 O O . HOH F 4 . ? 14.277 55.503 42.695 1.00 39.66 ? 665 HOH A O 1 HETATM 5269 O O . HOH F 4 . ? 29.735 70.796 30.616 1.00 45.64 ? 666 HOH A O 1 HETATM 5270 O O . HOH F 4 . ? 15.258 51.701 56.899 1.00 37.67 ? 667 HOH A O 1 HETATM 5271 O O . HOH F 4 . ? 40.568 73.634 53.106 1.00 31.36 ? 668 HOH A O 1 HETATM 5272 O O . HOH F 4 . ? 24.628 65.861 38.111 1.00 35.76 ? 669 HOH A O 1 HETATM 5273 O O . HOH F 4 . ? 51.041 76.602 59.971 1.00 52.29 ? 670 HOH A O 1 HETATM 5274 O O . HOH F 4 . ? 41.209 67.272 31.207 1.00 43.96 ? 671 HOH A O 1 HETATM 5275 O O . HOH F 4 . ? 22.561 62.914 61.908 1.00 47.22 ? 672 HOH A O 1 HETATM 5276 O O . HOH F 4 . ? 26.752 51.838 59.895 1.00 32.24 ? 673 HOH A O 1 HETATM 5277 O O . HOH F 4 . ? 26.835 66.954 39.233 1.00 29.38 ? 674 HOH A O 1 HETATM 5278 O O . HOH F 4 . ? 25.205 50.073 33.588 1.00 40.51 ? 675 HOH A O 1 HETATM 5279 O O . HOH F 4 . ? 28.729 50.642 58.584 1.00 44.45 ? 676 HOH A O 1 HETATM 5280 O O . HOH F 4 . ? 17.454 65.396 39.062 1.00 47.50 ? 677 HOH A O 1 HETATM 5281 O O . HOH F 4 . ? 19.880 43.412 33.379 1.00 45.92 ? 678 HOH A O 1 HETATM 5282 O O . HOH F 4 . ? 32.397 49.627 57.296 1.00 32.76 ? 679 HOH A O 1 HETATM 5283 O O . HOH F 4 . ? 18.698 43.306 59.305 1.00 39.46 ? 680 HOH A O 1 HETATM 5284 O O . HOH F 4 . ? 43.853 65.689 59.037 1.00 50.32 ? 681 HOH A O 1 HETATM 5285 O O . HOH F 4 . ? 10.927 65.260 42.164 1.00 44.52 ? 682 HOH A O 1 HETATM 5286 O O . HOH F 4 . ? 22.905 47.466 60.778 1.00 35.68 ? 683 HOH A O 1 HETATM 5287 O O . HOH F 4 . ? 21.075 41.968 58.155 1.00 41.12 ? 684 HOH A O 1 HETATM 5288 O O . HOH F 4 . ? 9.897 67.621 49.858 1.00 43.84 ? 685 HOH A O 1 HETATM 5289 O O . HOH F 4 . ? 35.765 89.799 45.017 1.00 52.56 ? 686 HOH A O 1 HETATM 5290 O O . HOH F 4 . ? 28.200 82.619 35.453 1.00 44.14 ? 687 HOH A O 1 HETATM 5291 O O . HOH F 4 . ? 24.800 86.646 44.490 1.00 37.78 ? 688 HOH A O 1 HETATM 5292 O O . HOH F 4 . ? 20.053 55.400 60.650 1.00 41.57 ? 689 HOH A O 1 HETATM 5293 O O . HOH F 4 . ? 40.186 75.441 55.085 1.00 33.16 ? 690 HOH A O 1 HETATM 5294 O O . HOH F 4 . ? 19.817 79.181 36.471 1.00 52.27 ? 691 HOH A O 1 HETATM 5295 O O . HOH F 4 . ? 22.542 48.520 63.305 1.00 59.45 ? 692 HOH A O 1 HETATM 5296 O O . HOH F 4 . ? 36.480 63.190 66.231 1.00 57.94 ? 693 HOH A O 1 HETATM 5297 O O . HOH F 4 . ? 12.627 75.930 46.910 1.00 38.15 ? 694 HOH A O 1 HETATM 5298 O O . HOH F 4 . ? 43.484 62.116 35.337 1.00 50.69 ? 695 HOH A O 1 HETATM 5299 O O . HOH F 4 . ? 26.968 43.292 37.274 1.00 52.22 ? 696 HOH A O 1 HETATM 5300 O O . HOH F 4 . ? 13.672 70.118 41.220 1.00 53.40 ? 697 HOH A O 1 HETATM 5301 O O . HOH F 4 . ? 14.397 83.241 44.221 1.00 69.29 ? 698 HOH A O 1 HETATM 5302 O O . HOH F 4 . ? 18.171 40.544 42.300 1.00 42.25 ? 699 HOH A O 1 HETATM 5303 O O . HOH F 4 . ? 36.641 67.657 62.225 1.00 45.24 ? 700 HOH A O 1 HETATM 5304 O O . HOH F 4 . ? 34.834 50.961 57.120 1.00 34.08 ? 701 HOH A O 1 HETATM 5305 O O . HOH F 4 . ? 16.973 58.726 60.493 1.00 48.46 ? 702 HOH A O 1 HETATM 5306 O O . HOH F 4 . ? 42.258 76.003 33.088 1.00 53.27 ? 703 HOH A O 1 HETATM 5307 O O . HOH F 4 . ? 51.727 59.851 45.518 1.00 42.71 ? 704 HOH A O 1 HETATM 5308 O O . HOH F 4 . ? 42.866 57.384 52.494 1.00 58.07 ? 705 HOH A O 1 HETATM 5309 O O . HOH F 4 . ? 30.101 59.874 38.327 1.00 49.57 ? 706 HOH A O 1 HETATM 5310 O O . HOH F 4 . ? 28.260 88.630 43.655 1.00 59.37 ? 707 HOH A O 1 HETATM 5311 O O . HOH F 4 . ? 49.212 81.562 51.340 1.00 38.28 ? 708 HOH A O 1 HETATM 5312 O O . HOH F 4 . ? 30.393 84.148 49.163 1.00 51.39 ? 709 HOH A O 1 HETATM 5313 O O . HOH F 4 . ? 48.206 80.489 55.296 1.00 51.99 ? 710 HOH A O 1 HETATM 5314 O O . HOH F 4 . ? 28.606 60.512 61.516 1.00 59.98 ? 711 HOH A O 1 HETATM 5315 O O . HOH F 4 . ? 27.828 79.707 35.434 1.00 48.55 ? 712 HOH A O 1 HETATM 5316 O O . HOH F 4 . ? 30.063 84.503 43.556 1.00 46.85 ? 713 HOH A O 1 HETATM 5317 O O . HOH F 4 . ? 22.265 85.122 52.560 1.00 49.00 ? 714 HOH A O 1 HETATM 5318 O O . HOH F 4 . ? 18.836 81.248 39.371 1.00 47.33 ? 715 HOH A O 1 HETATM 5319 O O . HOH F 4 . ? 35.185 63.131 38.629 1.00 43.83 ? 716 HOH A O 1 HETATM 5320 O O . HOH F 4 . ? 28.811 57.365 37.071 1.00 54.36 ? 717 HOH A O 1 HETATM 5321 O O . HOH F 4 . ? 22.623 54.693 32.018 1.00 45.77 ? 718 HOH A O 1 HETATM 5322 O O . HOH F 4 . ? 22.319 58.605 32.256 1.00 60.63 ? 719 HOH A O 1 HETATM 5323 O O . HOH F 4 . ? 50.641 75.810 55.846 1.00 46.91 ? 720 HOH A O 1 HETATM 5324 O O . HOH G 4 . ? 31.104 90.296 79.684 1.00 35.63 ? 601 HOH B O 1 HETATM 5325 O O . HOH G 4 . ? 33.646 95.843 84.958 1.00 31.41 ? 602 HOH B O 1 HETATM 5326 O O . HOH G 4 . ? 38.119 90.341 89.586 1.00 39.25 ? 603 HOH B O 1 HETATM 5327 O O . HOH G 4 . ? 30.398 84.268 84.086 1.00 28.25 ? 604 HOH B O 1 HETATM 5328 O O . HOH G 4 . ? 61.970 72.783 73.243 1.00 41.87 ? 605 HOH B O 1 HETATM 5329 O O . HOH G 4 . ? 57.980 82.752 65.921 1.00 40.06 ? 606 HOH B O 1 HETATM 5330 O O . HOH G 4 . ? 28.187 94.283 75.767 1.00 39.88 ? 607 HOH B O 1 HETATM 5331 O O . HOH G 4 . ? 33.570 94.547 88.744 1.00 36.14 ? 608 HOH B O 1 HETATM 5332 O O . HOH G 4 . ? 24.104 99.529 79.430 1.00 56.31 ? 609 HOH B O 1 HETATM 5333 O O . HOH G 4 . ? 33.530 92.797 86.562 1.00 30.01 ? 610 HOH B O 1 HETATM 5334 O O . HOH G 4 . ? 29.696 93.323 77.792 1.00 36.25 ? 611 HOH B O 1 HETATM 5335 O O . HOH G 4 . ? 25.204 98.266 76.936 1.00 44.46 ? 612 HOH B O 1 HETATM 5336 O O . HOH G 4 . ? 38.633 92.957 89.310 1.00 29.78 ? 613 HOH B O 1 HETATM 5337 O O . HOH G 4 . ? 30.265 82.344 81.300 1.00 57.46 ? 614 HOH B O 1 HETATM 5338 O O . HOH G 4 . ? 34.111 100.518 83.217 1.00 59.42 ? 615 HOH B O 1 HETATM 5339 O O . HOH G 4 . ? 69.401 69.402 72.765 1.00 46.11 ? 616 HOH B O 1 HETATM 5340 O O . HOH G 4 . ? 63.371 60.490 72.303 1.00 40.90 ? 617 HOH B O 1 HETATM 5341 O O . HOH G 4 . ? 54.250 80.102 72.760 1.00 32.44 ? 618 HOH B O 1 HETATM 5342 O O . HOH G 4 . ? 53.318 76.307 75.836 1.00 35.94 ? 619 HOH B O 1 HETATM 5343 O O . HOH G 4 . ? 64.551 85.135 78.369 1.00 31.84 ? 620 HOH B O 1 HETATM 5344 O O . HOH G 4 . ? 31.806 101.310 58.227 1.00 43.01 ? 621 HOH B O 1 HETATM 5345 O O . HOH G 4 . ? 41.198 80.053 92.916 1.00 44.60 ? 622 HOH B O 1 HETATM 5346 O O . HOH G 4 . ? 53.670 73.775 75.226 1.00 45.91 ? 623 HOH B O 1 HETATM 5347 O O . HOH G 4 . ? 33.184 77.703 86.062 1.00 45.69 ? 624 HOH B O 1 HETATM 5348 O O . HOH G 4 . ? 46.895 75.744 62.247 1.00 34.07 ? 625 HOH B O 1 HETATM 5349 O O . HOH G 4 . ? 42.498 79.247 73.981 1.00 30.57 ? 626 HOH B O 1 HETATM 5350 O O . HOH G 4 . ? 36.879 82.048 69.767 1.00 29.12 ? 627 HOH B O 1 HETATM 5351 O O . HOH G 4 . ? 69.164 79.075 73.141 1.00 35.54 ? 628 HOH B O 1 HETATM 5352 O O . HOH G 4 . ? 42.724 94.735 88.055 1.00 40.33 ? 629 HOH B O 1 HETATM 5353 O O . HOH G 4 . ? 57.428 91.195 80.687 1.00 33.98 ? 630 HOH B O 1 HETATM 5354 O O . HOH G 4 . ? 46.032 86.571 66.300 1.00 41.99 ? 631 HOH B O 1 HETATM 5355 O O . HOH G 4 . ? 53.477 70.791 86.645 1.00 41.74 ? 632 HOH B O 1 HETATM 5356 O O . HOH G 4 . ? 36.654 77.426 83.267 1.00 41.13 ? 633 HOH B O 1 HETATM 5357 O O . HOH G 4 . ? 40.963 83.691 58.383 1.00 37.14 ? 634 HOH B O 1 HETATM 5358 O O . HOH G 4 . ? 37.401 82.648 58.969 1.00 34.95 ? 635 HOH B O 1 HETATM 5359 O O . HOH G 4 . ? 44.532 98.949 82.478 1.00 35.72 ? 636 HOH B O 1 HETATM 5360 O O . HOH G 4 . ? 45.469 99.567 74.229 1.00 39.58 ? 637 HOH B O 1 HETATM 5361 O O . HOH G 4 . ? 43.554 90.960 90.282 1.00 34.89 ? 638 HOH B O 1 HETATM 5362 O O . HOH G 4 . ? 25.557 86.154 63.431 1.00 49.71 ? 639 HOH B O 1 HETATM 5363 O O . HOH G 4 . ? 38.060 87.397 57.222 1.00 36.16 ? 640 HOH B O 1 HETATM 5364 O O . HOH G 4 . ? 43.619 77.358 87.462 1.00 41.12 ? 641 HOH B O 1 HETATM 5365 O O . HOH G 4 . ? 55.615 87.572 75.521 1.00 57.24 ? 642 HOH B O 1 HETATM 5366 O O . HOH G 4 . ? 44.559 101.745 62.127 1.00 43.47 ? 643 HOH B O 1 HETATM 5367 O O . HOH G 4 . ? 38.371 84.726 57.591 1.00 38.53 ? 644 HOH B O 1 HETATM 5368 O O . HOH G 4 . ? 49.887 100.837 47.184 1.00 43.08 ? 645 HOH B O 1 HETATM 5369 O O . HOH G 4 . ? 41.572 93.228 90.002 1.00 43.32 ? 646 HOH B O 1 HETATM 5370 O O . HOH G 4 . ? 27.298 87.499 71.781 1.00 42.09 ? 647 HOH B O 1 HETATM 5371 O O . HOH G 4 . ? 53.307 71.697 91.388 1.00 46.56 ? 648 HOH B O 1 HETATM 5372 O O . HOH G 4 . ? 28.758 74.561 75.810 1.00 50.26 ? 649 HOH B O 1 HETATM 5373 O O . HOH G 4 . ? 43.021 98.987 64.858 1.00 36.22 ? 650 HOH B O 1 HETATM 5374 O O . HOH G 4 . ? 37.946 81.457 85.186 1.00 43.14 ? 651 HOH B O 1 HETATM 5375 O O . HOH G 4 . ? 29.092 88.034 60.439 1.00 41.73 ? 652 HOH B O 1 HETATM 5376 O O . HOH G 4 . ? 43.887 72.391 80.008 1.00 45.81 ? 653 HOH B O 1 HETATM 5377 O O . HOH G 4 . ? 51.243 76.730 91.815 1.00 51.51 ? 654 HOH B O 1 HETATM 5378 O O . HOH G 4 . ? 42.641 97.480 89.441 1.00 48.75 ? 655 HOH B O 1 HETATM 5379 O O . HOH G 4 . ? 68.044 82.114 86.756 1.00 41.99 ? 656 HOH B O 1 HETATM 5380 O O . HOH G 4 . ? 44.269 102.718 64.659 1.00 43.27 ? 657 HOH B O 1 HETATM 5381 O O . HOH G 4 . ? 52.772 67.462 77.299 1.00 62.17 ? 658 HOH B O 1 HETATM 5382 O O . HOH G 4 . ? 48.856 86.462 52.334 1.00 49.62 ? 659 HOH B O 1 HETATM 5383 O O . HOH G 4 . ? 37.460 103.597 76.390 1.00 49.21 ? 660 HOH B O 1 HETATM 5384 O O . HOH G 4 . ? 27.795 97.250 68.560 1.00 51.63 ? 661 HOH B O 1 HETATM 5385 O O . HOH G 4 . ? 54.700 70.429 74.565 1.00 53.70 ? 662 HOH B O 1 HETATM 5386 O O . HOH G 4 . ? 31.319 73.521 80.512 1.00 42.17 ? 663 HOH B O 1 HETATM 5387 O O . HOH G 4 . ? 48.925 73.801 91.722 1.00 52.26 ? 664 HOH B O 1 HETATM 5388 O O . HOH G 4 . ? 52.945 68.363 85.079 1.00 53.51 ? 665 HOH B O 1 HETATM 5389 O O . HOH G 4 . ? 50.245 79.778 56.873 1.00 43.82 ? 666 HOH B O 1 HETATM 5390 O O . HOH G 4 . ? 62.859 80.486 77.532 1.00 46.86 ? 667 HOH B O 1 HETATM 5391 O O . HOH G 4 . ? 49.551 83.160 93.401 1.00 52.24 ? 668 HOH B O 1 HETATM 5392 O O . HOH G 4 . ? 46.604 97.136 75.385 1.00 34.32 ? 669 HOH B O 1 HETATM 5393 O O . HOH G 4 . ? 36.138 79.432 84.988 1.00 53.32 ? 670 HOH B O 1 HETATM 5394 O O . HOH G 4 . ? 49.359 97.971 65.584 1.00 38.11 ? 671 HOH B O 1 HETATM 5395 O O . HOH G 4 . ? 50.797 85.772 67.545 1.00 41.50 ? 672 HOH B O 1 HETATM 5396 O O . HOH G 4 . ? 46.965 100.044 83.111 1.00 39.19 ? 673 HOH B O 1 HETATM 5397 O O . HOH G 4 . ? 36.046 100.517 76.865 1.00 46.58 ? 674 HOH B O 1 HETATM 5398 O O . HOH G 4 . ? 46.509 81.530 57.117 1.00 42.62 ? 675 HOH B O 1 HETATM 5399 O O . HOH G 4 . ? 40.470 97.566 67.226 1.00 47.29 ? 676 HOH B O 1 HETATM 5400 O O . HOH G 4 . ? 46.584 74.281 66.461 1.00 48.19 ? 677 HOH B O 1 HETATM 5401 O O . HOH G 4 . ? 39.628 104.464 60.969 1.00 44.46 ? 678 HOH B O 1 HETATM 5402 O O . HOH G 4 . ? 47.324 106.840 50.944 1.00 51.96 ? 679 HOH B O 1 HETATM 5403 O O . HOH G 4 . ? 44.235 87.993 47.202 1.00 49.47 ? 680 HOH B O 1 HETATM 5404 O O . HOH G 4 . ? 42.439 73.335 73.008 1.00 43.64 ? 681 HOH B O 1 HETATM 5405 O O . HOH G 4 . ? 39.582 98.932 69.549 1.00 43.60 ? 682 HOH B O 1 HETATM 5406 O O . HOH G 4 . ? 39.281 97.020 71.571 1.00 40.50 ? 683 HOH B O 1 HETATM 5407 O O . HOH G 4 . ? 39.327 102.667 71.855 1.00 51.53 ? 684 HOH B O 1 HETATM 5408 O O . HOH G 4 . ? 42.148 95.097 44.800 1.00 56.17 ? 685 HOH B O 1 HETATM 5409 O O . HOH G 4 . ? 38.110 99.831 85.042 1.00 52.47 ? 686 HOH B O 1 HETATM 5410 O O . HOH G 4 . ? 49.473 100.958 68.061 1.00 47.96 ? 687 HOH B O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 LEU 1 67 ? ? ? A . n A 1 2 THR 2 68 68 THR THR A . n A 1 3 LEU 3 69 69 LEU LEU A . n A 1 4 GLY 4 70 70 GLY GLY A . n A 1 5 ASN 5 71 71 ASN ASN A . n A 1 6 THR 6 72 72 THR THR A . n A 1 7 THR 7 73 73 THR THR A . n A 1 8 SER 8 74 74 SER SER A . n A 1 9 SER 9 75 75 SER SER A . n A 1 10 VAL 10 76 76 VAL VAL A . n A 1 11 ILE 11 77 77 ILE ILE A . n A 1 12 LEU 12 78 78 LEU LEU A . n A 1 13 THR 13 79 79 THR THR A . n A 1 14 ASN 14 80 80 ASN ASN A . n A 1 15 TYR 15 81 81 TYR TYR A . n A 1 16 MET 16 82 82 MET MET A . n A 1 17 ASP 17 83 83 ASP ASP A . n A 1 18 THR 18 84 84 THR THR A . n A 1 19 GLN 19 85 85 GLN GLN A . n A 1 20 TYR 20 86 86 TYR TYR A . n A 1 21 TYR 21 87 87 TYR TYR A . n A 1 22 GLY 22 88 88 GLY GLY A . n A 1 23 GLU 23 89 89 GLU GLU A . n A 1 24 ILE 24 90 90 ILE ILE A . n A 1 25 GLY 25 91 91 GLY GLY A . n A 1 26 ILE 26 92 92 ILE ILE A . n A 1 27 GLY 27 93 93 GLY GLY A . n A 1 28 THR 28 94 94 THR THR A . n A 1 29 PRO 29 95 95 PRO PRO A . n A 1 30 PRO 30 96 96 PRO PRO A . n A 1 31 GLN 31 97 97 GLN GLN A . n A 1 32 THR 32 98 98 THR THR A . n A 1 33 PHE 33 99 99 PHE PHE A . n A 1 34 LYS 34 100 100 LYS LYS A . n A 1 35 VAL 35 101 101 VAL VAL A . n A 1 36 VAL 36 102 102 VAL VAL A . n A 1 37 PHE 37 103 103 PHE PHE A . n A 1 38 ASP 38 104 104 ASP ASP A . n A 1 39 THR 39 105 105 THR THR A . n A 1 40 GLY 40 106 106 GLY GLY A . n A 1 41 SER 41 107 107 SER SER A . n A 1 42 SER 42 108 108 SER SER A . n A 1 43 ASN 43 109 109 ASN ASN A . n A 1 44 VAL 44 110 110 VAL VAL A . n A 1 45 TRP 45 111 111 TRP TRP A . n A 1 46 VAL 46 112 112 VAL VAL A . n A 1 47 PRO 47 113 113 PRO PRO A . n A 1 48 SER 48 114 114 SER SER A . n A 1 49 SER 49 115 115 SER SER A . n A 1 50 LYS 50 116 116 LYS LYS A . n A 1 51 CYS 51 117 117 CYS CYS A . n A 1 52 SER 52 118 118 SER SER A . n A 1 53 ARG 53 119 119 ARG ARG A . n A 1 54 LEU 54 120 120 LEU LEU A . n A 1 55 TYR 55 121 121 TYR TYR A . n A 1 56 THR 56 122 122 THR THR A . n A 1 57 ALA 57 123 123 ALA ALA A . n A 1 58 CYS 58 124 124 CYS CYS A . n A 1 59 VAL 59 125 125 VAL VAL A . n A 1 60 TYR 60 126 126 TYR TYR A . n A 1 61 HIS 61 127 127 HIS HIS A . n A 1 62 LYS 62 128 128 LYS LYS A . n A 1 63 LEU 63 129 129 LEU LEU A . n A 1 64 PHE 64 130 130 PHE PHE A . n A 1 65 ASP 65 131 131 ASP ASP A . n A 1 66 ALA 66 132 132 ALA ALA A . n A 1 67 SER 67 133 133 SER SER A . n A 1 68 ASP 68 134 134 ASP ASP A . n A 1 69 SER 69 135 135 SER SER A . n A 1 70 SER 70 136 136 SER SER A . n A 1 71 SER 71 137 137 SER SER A . n A 1 72 TYR 72 138 138 TYR TYR A . n A 1 73 LYS 73 139 139 LYS LYS A . n A 1 74 HIS 74 140 140 HIS HIS A . n A 1 75 ASN 75 141 141 ASN ASN A . n A 1 76 GLY 76 142 142 GLY GLY A . n A 1 77 THR 77 143 143 THR THR A . n A 1 78 GLU 78 144 144 GLU GLU A . n A 1 79 LEU 79 145 145 LEU LEU A . n A 1 80 THR 80 146 146 THR THR A . n A 1 81 LEU 81 147 147 LEU LEU A . n A 1 82 ARG 82 148 148 ARG ARG A . n A 1 83 TYR 83 149 149 TYR TYR A . n A 1 84 SER 84 150 150 SER SER A . n A 1 85 THR 85 151 151 THR THR A . n A 1 86 GLY 86 152 152 GLY GLY A . n A 1 87 THR 87 153 153 THR THR A . n A 1 88 VAL 88 154 154 VAL VAL A . n A 1 89 SER 89 155 155 SER SER A . n A 1 90 GLY 90 156 156 GLY GLY A . n A 1 91 PHE 91 157 157 PHE PHE A . n A 1 92 LEU 92 158 158 LEU LEU A . n A 1 93 SER 93 159 159 SER SER A . n A 1 94 GLN 94 160 160 GLN GLN A . n A 1 95 ASP 95 161 161 ASP ASP A . n A 1 96 ILE 96 162 162 ILE ILE A . n A 1 97 ILE 97 163 163 ILE ILE A . n A 1 98 THR 98 164 164 THR THR A . n A 1 99 VAL 99 165 165 VAL VAL A . n A 1 100 GLY 100 166 166 GLY GLY A . n A 1 101 GLY 101 167 167 GLY GLY A . n A 1 102 ILE 102 168 168 ILE ILE A . n A 1 103 THR 103 169 169 THR THR A . n A 1 104 VAL 104 170 170 VAL VAL A . n A 1 105 THR 105 171 171 THR THR A . n A 1 106 GLN 106 172 172 GLN GLN A . n A 1 107 MET 107 173 173 MET MET A . n A 1 108 PHE 108 174 174 PHE PHE A . n A 1 109 GLY 109 175 175 GLY GLY A . n A 1 110 GLU 110 176 176 GLU GLU A . n A 1 111 VAL 111 177 177 VAL VAL A . n A 1 112 THR 112 178 178 THR THR A . n A 1 113 GLU 113 179 179 GLU GLU A . n A 1 114 MET 114 180 180 MET MET A . n A 1 115 PRO 115 181 181 PRO PRO A . n A 1 116 ALA 116 182 182 ALA ALA A . n A 1 117 LEU 117 183 183 LEU LEU A . n A 1 118 PRO 118 184 184 PRO PRO A . n A 1 119 PHE 119 185 185 PHE PHE A . n A 1 120 MET 120 186 186 MET MET A . n A 1 121 LEU 121 187 187 LEU LEU A . n A 1 122 ALA 122 188 188 ALA ALA A . n A 1 123 GLU 123 189 189 GLU GLU A . n A 1 124 PHE 124 190 190 PHE PHE A . n A 1 125 ASP 125 191 191 ASP ASP A . n A 1 126 GLY 126 192 192 GLY GLY A . n A 1 127 VAL 127 193 193 VAL VAL A . n A 1 128 VAL 128 194 194 VAL VAL A . n A 1 129 GLY 129 195 195 GLY GLY A . n A 1 130 MET 130 196 196 MET MET A . n A 1 131 GLY 131 197 197 GLY GLY A . n A 1 132 PHE 132 198 198 PHE PHE A . n A 1 133 ILE 133 199 199 ILE ILE A . n A 1 134 GLU 134 200 200 GLU GLU A . n A 1 135 GLN 135 201 201 GLN GLN A . n A 1 136 ALA 136 202 202 ALA ALA A . n A 1 137 ILE 137 203 203 ILE ILE A . n A 1 138 GLY 138 204 204 GLY GLY A . n A 1 139 ARG 139 205 205 ARG ARG A . n A 1 140 VAL 140 206 206 VAL VAL A . n A 1 141 THR 141 207 207 THR THR A . n A 1 142 PRO 142 208 208 PRO PRO A . n A 1 143 ILE 143 209 209 ILE ILE A . n A 1 144 PHE 144 210 210 PHE PHE A . n A 1 145 ASP 145 211 211 ASP ASP A . n A 1 146 ASN 146 212 212 ASN ASN A . n A 1 147 ILE 147 213 213 ILE ILE A . n A 1 148 ILE 148 214 214 ILE ILE A . n A 1 149 SER 149 215 215 SER SER A . n A 1 150 GLN 150 216 216 GLN GLN A . n A 1 151 GLY 151 217 217 GLY GLY A . n A 1 152 VAL 152 218 218 VAL VAL A . n A 1 153 LEU 153 219 219 LEU LEU A . n A 1 154 LYS 154 220 220 LYS LYS A . n A 1 155 GLU 155 221 221 GLU GLU A . n A 1 156 ASP 156 222 222 ASP ASP A . n A 1 157 VAL 157 223 223 VAL VAL A . n A 1 158 PHE 158 224 224 PHE PHE A . n A 1 159 SER 159 225 225 SER SER A . n A 1 160 PHE 160 226 226 PHE PHE A . n A 1 161 TYR 161 227 227 TYR TYR A . n A 1 162 TYR 162 228 228 TYR TYR A . n A 1 163 ASN 163 229 229 ASN ASN A . n A 1 164 ARG 164 230 230 ARG ARG A . n A 1 165 ASP 165 231 231 ASP ASP A . n A 1 166 SER 166 232 232 SER SER A . n A 1 167 GLU 167 233 233 GLU GLU A . n A 1 168 ASN 168 234 234 ASN ASN A . n A 1 169 SER 169 235 235 SER SER A . n A 1 170 GLN 170 236 236 GLN GLN A . n A 1 171 SER 171 237 237 SER SER A . n A 1 172 LEU 172 238 238 LEU LEU A . n A 1 173 GLY 173 239 239 GLY GLY A . n A 1 174 GLY 174 240 240 GLY GLY A . n A 1 175 GLN 175 241 241 GLN GLN A . n A 1 176 ILE 176 242 242 ILE ILE A . n A 1 177 VAL 177 243 243 VAL VAL A . n A 1 178 LEU 178 244 244 LEU LEU A . n A 1 179 GLY 179 245 245 GLY GLY A . n A 1 180 GLY 180 246 246 GLY GLY A . n A 1 181 SER 181 247 247 SER SER A . n A 1 182 ASP 182 248 248 ASP ASP A . n A 1 183 PRO 183 249 249 PRO PRO A . n A 1 184 GLN 184 250 250 GLN GLN A . n A 1 185 HIS 185 251 251 HIS HIS A . n A 1 186 TYR 186 252 252 TYR TYR A . n A 1 187 GLU 187 253 253 GLU GLU A . n A 1 188 GLY 188 254 254 GLY GLY A . n A 1 189 ASN 189 255 255 ASN ASN A . n A 1 190 PHE 190 256 256 PHE PHE A . n A 1 191 HIS 191 257 257 HIS HIS A . n A 1 192 TYR 192 258 258 TYR TYR A . n A 1 193 ILE 193 259 259 ILE ILE A . n A 1 194 ASN 194 260 260 ASN ASN A . n A 1 195 LEU 195 261 261 LEU LEU A . n A 1 196 ILE 196 262 262 ILE ILE A . n A 1 197 LYS 197 263 263 LYS LYS A . n A 1 198 THR 198 264 264 THR THR A . n A 1 199 GLY 199 265 265 GLY GLY A . n A 1 200 VAL 200 266 266 VAL VAL A . n A 1 201 TRP 201 267 267 TRP TRP A . n A 1 202 GLN 202 268 268 GLN GLN A . n A 1 203 ILE 203 269 269 ILE ILE A . n A 1 204 GLN 204 270 270 GLN GLN A . n A 1 205 MET 205 271 271 MET MET A . n A 1 206 LYS 206 272 272 LYS LYS A . n A 1 207 GLY 207 273 273 GLY GLY A . n A 1 208 VAL 208 274 274 VAL VAL A . n A 1 209 SER 209 275 275 SER SER A . n A 1 210 VAL 210 276 276 VAL VAL A . n A 1 211 GLY 211 277 277 GLY GLY A . n A 1 212 SER 212 278 278 SER SER A . n A 1 213 SER 213 279 279 SER SER A . n A 1 214 THR 214 280 280 THR THR A . n A 1 215 LEU 215 281 281 LEU LEU A . n A 1 216 LEU 216 282 282 LEU LEU A . n A 1 217 CYS 217 283 283 CYS CYS A . n A 1 218 GLU 218 284 284 GLU GLU A . n A 1 219 ASP 219 285 285 ASP ASP A . n A 1 220 GLY 220 286 286 GLY GLY A . n A 1 221 CYS 221 287 287 CYS CYS A . n A 1 222 LEU 222 288 288 LEU LEU A . n A 1 223 ALA 223 289 289 ALA ALA A . n A 1 224 LEU 224 290 290 LEU LEU A . n A 1 225 VAL 225 291 291 VAL VAL A . n A 1 226 ASP 226 292 292 ASP ASP A . n A 1 227 THR 227 293 293 THR THR A . n A 1 228 GLY 228 294 294 GLY GLY A . n A 1 229 ALA 229 295 295 ALA ALA A . n A 1 230 SER 230 296 296 SER SER A . n A 1 231 TYR 231 297 297 TYR TYR A . n A 1 232 ILE 232 298 298 ILE ILE A . n A 1 233 SER 233 299 299 SER SER A . n A 1 234 GLY 234 300 300 GLY GLY A . n A 1 235 SER 235 301 301 SER SER A . n A 1 236 THR 236 302 302 THR THR A . n A 1 237 SER 237 303 303 SER SER A . n A 1 238 SER 238 304 304 SER SER A . n A 1 239 ILE 239 305 305 ILE ILE A . n A 1 240 GLU 240 306 306 GLU GLU A . n A 1 241 LYS 241 307 307 LYS LYS A . n A 1 242 LEU 242 308 308 LEU LEU A . n A 1 243 MET 243 309 309 MET MET A . n A 1 244 GLU 244 310 310 GLU GLU A . n A 1 245 ALA 245 311 311 ALA ALA A . n A 1 246 LEU 246 312 312 LEU LEU A . n A 1 247 GLY 247 313 313 GLY GLY A . n A 1 248 ALA 248 314 314 ALA ALA A . n A 1 249 LYS 249 315 315 LYS ALA A . n A 1 250 LYS 250 316 316 LYS LYS A . n A 1 251 ARG 251 317 317 ARG ARG A . n A 1 252 LEU 252 318 318 LEU LEU A . n A 1 253 PHE 253 319 319 PHE PHE A . n A 1 254 ASP 254 320 320 ASP ASP A . n A 1 255 TYR 255 321 321 TYR TYR A . n A 1 256 VAL 256 322 322 VAL VAL A . n A 1 257 VAL 257 323 323 VAL VAL A . n A 1 258 LYS 258 324 324 LYS LYS A . n A 1 259 CYS 259 325 325 CYS CYS A . n A 1 260 ASN 260 326 326 ASN ASN A . n A 1 261 GLU 261 327 327 GLU GLU A . n A 1 262 GLY 262 328 328 GLY GLY A . n A 1 263 PRO 263 329 329 PRO PRO A . n A 1 264 THR 264 330 330 THR THR A . n A 1 265 LEU 265 331 331 LEU LEU A . n A 1 266 PRO 266 332 332 PRO PRO A . n A 1 267 ASP 267 333 333 ASP ASP A . n A 1 268 ILE 268 334 334 ILE ILE A . n A 1 269 SER 269 335 335 SER SER A . n A 1 270 PHE 270 336 336 PHE PHE A . n A 1 271 HIS 271 337 337 HIS HIS A . n A 1 272 LEU 272 338 338 LEU LEU A . n A 1 273 GLY 273 339 339 GLY GLY A . n A 1 274 GLY 274 340 340 GLY GLY A . n A 1 275 LYS 275 341 341 LYS LYS A . n A 1 276 GLU 276 342 342 GLU GLU A . n A 1 277 TYR 277 343 343 TYR TYR A . n A 1 278 THR 278 344 344 THR THR A . n A 1 279 LEU 279 345 345 LEU LEU A . n A 1 280 THR 280 346 346 THR THR A . n A 1 281 SER 281 347 347 SER SER A . n A 1 282 ALA 282 348 348 ALA ALA A . n A 1 283 ASP 283 349 349 ASP ASP A . n A 1 284 TYR 284 350 350 TYR TYR A . n A 1 285 VAL 285 351 351 VAL VAL A . n A 1 286 PHE 286 352 352 PHE PHE A . n A 1 287 GLN 287 353 353 GLN GLN A . n A 1 288 GLU 288 354 354 GLU GLU A . n A 1 289 SER 289 355 355 SER SER A . n A 1 290 TYR 290 356 356 TYR TYR A . n A 1 291 SER 291 357 357 SER SER A . n A 1 292 SER 292 358 358 SER SER A . n A 1 293 LYS 293 359 359 LYS LYS A . n A 1 294 LYS 294 360 360 LYS LYS A . n A 1 295 LEU 295 361 361 LEU LEU A . n A 1 296 CYS 296 362 362 CYS CYS A . n A 1 297 THR 297 363 363 THR THR A . n A 1 298 LEU 298 364 364 LEU LEU A . n A 1 299 ALA 299 365 365 ALA ALA A . n A 1 300 ILE 300 366 366 ILE ILE A . n A 1 301 HIS 301 367 367 HIS HIS A . n A 1 302 ALA 302 368 368 ALA ALA A . n A 1 303 MET 303 369 369 MET MET A . n A 1 304 ASP 304 370 370 ASP ASP A . n A 1 305 ILE 305 371 371 ILE ILE A . n A 1 306 PRO 306 372 372 PRO PRO A . n A 1 307 PRO 307 373 373 PRO PRO A . n A 1 308 PRO 308 374 374 PRO PRO A . n A 1 309 THR 309 375 375 THR THR A . n A 1 310 GLY 310 376 376 GLY GLY A . n A 1 311 PRO 311 377 377 PRO PRO A . n A 1 312 THR 312 378 378 THR THR A . n A 1 313 TRP 313 379 379 TRP TRP A . n A 1 314 ALA 314 380 380 ALA ALA A . n A 1 315 LEU 315 381 381 LEU LEU A . n A 1 316 GLY 316 382 382 GLY GLY A . n A 1 317 ALA 317 383 383 ALA ALA A . n A 1 318 THR 318 384 384 THR THR A . n A 1 319 PHE 319 385 385 PHE PHE A . n A 1 320 ILE 320 386 386 ILE ILE A . n A 1 321 ARG 321 387 387 ARG ARG A . n A 1 322 LYS 322 388 388 LYS LYS A . n A 1 323 PHE 323 389 389 PHE PHE A . n A 1 324 TYR 324 390 390 TYR TYR A . n A 1 325 THR 325 391 391 THR THR A . n A 1 326 GLU 326 392 392 GLU GLU A . n A 1 327 PHE 327 393 393 PHE PHE A . n A 1 328 ASP 328 394 394 ASP ASP A . n A 1 329 ARG 329 395 395 ARG ARG A . n A 1 330 ARG 330 396 396 ARG ARG A . n A 1 331 ASN 331 397 397 ASN ASN A . n A 1 332 ASN 332 398 398 ASN ASN A . n A 1 333 ARG 333 399 399 ARG ARG A . n A 1 334 ILE 334 400 400 ILE ILE A . n A 1 335 GLY 335 401 401 GLY GLY A . n A 1 336 PHE 336 402 402 PHE PHE A . n A 1 337 ALA 337 403 403 ALA ALA A . n A 1 338 LEU 338 404 404 LEU LEU A . n A 1 339 ALA 339 405 405 ALA ALA A . n A 1 340 ARG 340 406 406 ARG ARG A . n B 1 1 LEU 1 67 67 LEU LEU B . n B 1 2 THR 2 68 68 THR THR B . n B 1 3 LEU 3 69 69 LEU LEU B . n B 1 4 GLY 4 70 70 GLY GLY B . n B 1 5 ASN 5 71 71 ASN ASN B . n B 1 6 THR 6 72 72 THR THR B . n B 1 7 THR 7 73 73 THR THR B . n B 1 8 SER 8 74 74 SER SER B . n B 1 9 SER 9 75 75 SER SER B . n B 1 10 VAL 10 76 76 VAL VAL B . n B 1 11 ILE 11 77 77 ILE ILE B . n B 1 12 LEU 12 78 78 LEU LEU B . n B 1 13 THR 13 79 79 THR THR B . n B 1 14 ASN 14 80 80 ASN ASN B . n B 1 15 TYR 15 81 81 TYR TYR B . n B 1 16 MET 16 82 82 MET MET B . n B 1 17 ASP 17 83 83 ASP ASP B . n B 1 18 THR 18 84 84 THR THR B . n B 1 19 GLN 19 85 85 GLN GLN B . n B 1 20 TYR 20 86 86 TYR TYR B . n B 1 21 TYR 21 87 87 TYR TYR B . n B 1 22 GLY 22 88 88 GLY GLY B . n B 1 23 GLU 23 89 89 GLU GLU B . n B 1 24 ILE 24 90 90 ILE ILE B . n B 1 25 GLY 25 91 91 GLY GLY B . n B 1 26 ILE 26 92 92 ILE ILE B . n B 1 27 GLY 27 93 93 GLY GLY B . n B 1 28 THR 28 94 94 THR THR B . n B 1 29 PRO 29 95 95 PRO PRO B . n B 1 30 PRO 30 96 96 PRO PRO B . n B 1 31 GLN 31 97 97 GLN GLN B . n B 1 32 THR 32 98 98 THR THR B . n B 1 33 PHE 33 99 99 PHE PHE B . n B 1 34 LYS 34 100 100 LYS LYS B . n B 1 35 VAL 35 101 101 VAL VAL B . n B 1 36 VAL 36 102 102 VAL VAL B . n B 1 37 PHE 37 103 103 PHE PHE B . n B 1 38 ASP 38 104 104 ASP ASP B . n B 1 39 THR 39 105 105 THR THR B . n B 1 40 GLY 40 106 106 GLY GLY B . n B 1 41 SER 41 107 107 SER SER B . n B 1 42 SER 42 108 108 SER SER B . n B 1 43 ASN 43 109 109 ASN ASN B . n B 1 44 VAL 44 110 110 VAL VAL B . n B 1 45 TRP 45 111 111 TRP TRP B . n B 1 46 VAL 46 112 112 VAL VAL B . n B 1 47 PRO 47 113 113 PRO PRO B . n B 1 48 SER 48 114 114 SER SER B . n B 1 49 SER 49 115 115 SER SER B . n B 1 50 LYS 50 116 116 LYS LYS B . n B 1 51 CYS 51 117 117 CYS CYS B . n B 1 52 SER 52 118 118 SER SER B . n B 1 53 ARG 53 119 119 ARG ARG B . n B 1 54 LEU 54 120 120 LEU LEU B . n B 1 55 TYR 55 121 121 TYR TYR B . n B 1 56 THR 56 122 122 THR THR B . n B 1 57 ALA 57 123 123 ALA ALA B . n B 1 58 CYS 58 124 124 CYS CYS B . n B 1 59 VAL 59 125 125 VAL VAL B . n B 1 60 TYR 60 126 126 TYR ALA B . n B 1 61 HIS 61 127 127 HIS HIS B . n B 1 62 LYS 62 128 128 LYS LYS B . n B 1 63 LEU 63 129 129 LEU LEU B . n B 1 64 PHE 64 130 130 PHE PHE B . n B 1 65 ASP 65 131 131 ASP ASP B . n B 1 66 ALA 66 132 132 ALA ALA B . n B 1 67 SER 67 133 133 SER SER B . n B 1 68 ASP 68 134 134 ASP ASP B . n B 1 69 SER 69 135 135 SER SER B . n B 1 70 SER 70 136 136 SER SER B . n B 1 71 SER 71 137 137 SER SER B . n B 1 72 TYR 72 138 138 TYR TYR B . n B 1 73 LYS 73 139 139 LYS LYS B . n B 1 74 HIS 74 140 140 HIS HIS B . n B 1 75 ASN 75 141 141 ASN ASN B . n B 1 76 GLY 76 142 142 GLY GLY B . n B 1 77 THR 77 143 143 THR THR B . n B 1 78 GLU 78 144 144 GLU GLU B . n B 1 79 LEU 79 145 145 LEU LEU B . n B 1 80 THR 80 146 146 THR THR B . n B 1 81 LEU 81 147 147 LEU LEU B . n B 1 82 ARG 82 148 148 ARG ARG B . n B 1 83 TYR 83 149 149 TYR TYR B . n B 1 84 SER 84 150 150 SER SER B . n B 1 85 THR 85 151 151 THR THR B . n B 1 86 GLY 86 152 152 GLY GLY B . n B 1 87 THR 87 153 153 THR THR B . n B 1 88 VAL 88 154 154 VAL VAL B . n B 1 89 SER 89 155 155 SER SER B . n B 1 90 GLY 90 156 156 GLY GLY B . n B 1 91 PHE 91 157 157 PHE PHE B . n B 1 92 LEU 92 158 158 LEU LEU B . n B 1 93 SER 93 159 159 SER SER B . n B 1 94 GLN 94 160 160 GLN GLN B . n B 1 95 ASP 95 161 161 ASP ASP B . n B 1 96 ILE 96 162 162 ILE ILE B . n B 1 97 ILE 97 163 163 ILE ILE B . n B 1 98 THR 98 164 164 THR THR B . n B 1 99 VAL 99 165 165 VAL VAL B . n B 1 100 GLY 100 166 166 GLY GLY B . n B 1 101 GLY 101 167 167 GLY GLY B . n B 1 102 ILE 102 168 168 ILE ILE B . n B 1 103 THR 103 169 169 THR THR B . n B 1 104 VAL 104 170 170 VAL VAL B . n B 1 105 THR 105 171 171 THR THR B . n B 1 106 GLN 106 172 172 GLN GLN B . n B 1 107 MET 107 173 173 MET MET B . n B 1 108 PHE 108 174 174 PHE PHE B . n B 1 109 GLY 109 175 175 GLY GLY B . n B 1 110 GLU 110 176 176 GLU GLU B . n B 1 111 VAL 111 177 177 VAL VAL B . n B 1 112 THR 112 178 178 THR THR B . n B 1 113 GLU 113 179 179 GLU GLU B . n B 1 114 MET 114 180 180 MET MET B . n B 1 115 PRO 115 181 181 PRO PRO B . n B 1 116 ALA 116 182 182 ALA ALA B . n B 1 117 LEU 117 183 183 LEU LEU B . n B 1 118 PRO 118 184 184 PRO PRO B . n B 1 119 PHE 119 185 185 PHE PHE B . n B 1 120 MET 120 186 186 MET MET B . n B 1 121 LEU 121 187 187 LEU LEU B . n B 1 122 ALA 122 188 188 ALA ALA B . n B 1 123 GLU 123 189 189 GLU GLU B . n B 1 124 PHE 124 190 190 PHE PHE B . n B 1 125 ASP 125 191 191 ASP ASP B . n B 1 126 GLY 126 192 192 GLY GLY B . n B 1 127 VAL 127 193 193 VAL VAL B . n B 1 128 VAL 128 194 194 VAL VAL B . n B 1 129 GLY 129 195 195 GLY GLY B . n B 1 130 MET 130 196 196 MET MET B . n B 1 131 GLY 131 197 197 GLY GLY B . n B 1 132 PHE 132 198 198 PHE PHE B . n B 1 133 ILE 133 199 199 ILE ILE B . n B 1 134 GLU 134 200 200 GLU GLU B . n B 1 135 GLN 135 201 201 GLN GLN B . n B 1 136 ALA 136 202 202 ALA ALA B . n B 1 137 ILE 137 203 203 ILE ILE B . n B 1 138 GLY 138 204 204 GLY GLY B . n B 1 139 ARG 139 205 205 ARG ARG B . n B 1 140 VAL 140 206 206 VAL VAL B . n B 1 141 THR 141 207 207 THR THR B . n B 1 142 PRO 142 208 208 PRO PRO B . n B 1 143 ILE 143 209 209 ILE ILE B . n B 1 144 PHE 144 210 210 PHE PHE B . n B 1 145 ASP 145 211 211 ASP ASP B . n B 1 146 ASN 146 212 212 ASN ASN B . n B 1 147 ILE 147 213 213 ILE ILE B . n B 1 148 ILE 148 214 214 ILE ILE B . n B 1 149 SER 149 215 215 SER SER B . n B 1 150 GLN 150 216 216 GLN GLN B . n B 1 151 GLY 151 217 217 GLY GLY B . n B 1 152 VAL 152 218 218 VAL VAL B . n B 1 153 LEU 153 219 219 LEU LEU B . n B 1 154 LYS 154 220 220 LYS LYS B . n B 1 155 GLU 155 221 221 GLU GLU B . n B 1 156 ASP 156 222 222 ASP ASP B . n B 1 157 VAL 157 223 223 VAL VAL B . n B 1 158 PHE 158 224 224 PHE PHE B . n B 1 159 SER 159 225 225 SER SER B . n B 1 160 PHE 160 226 226 PHE PHE B . n B 1 161 TYR 161 227 227 TYR TYR B . n B 1 162 TYR 162 228 228 TYR TYR B . n B 1 163 ASN 163 229 229 ASN ASN B . n B 1 164 ARG 164 230 230 ARG ARG B . n B 1 165 ASP 165 231 231 ASP ASP B . n B 1 166 SER 166 232 232 SER SER B . n B 1 167 GLU 167 233 ? ? ? B . n B 1 168 ASN 168 234 ? ? ? B . n B 1 169 SER 169 235 235 SER SER B . n B 1 170 GLN 170 236 236 GLN GLN B . n B 1 171 SER 171 237 237 SER SER B . n B 1 172 LEU 172 238 238 LEU LEU B . n B 1 173 GLY 173 239 239 GLY GLY B . n B 1 174 GLY 174 240 240 GLY GLY B . n B 1 175 GLN 175 241 241 GLN GLN B . n B 1 176 ILE 176 242 242 ILE ILE B . n B 1 177 VAL 177 243 243 VAL VAL B . n B 1 178 LEU 178 244 244 LEU LEU B . n B 1 179 GLY 179 245 245 GLY GLY B . n B 1 180 GLY 180 246 246 GLY GLY B . n B 1 181 SER 181 247 247 SER SER B . n B 1 182 ASP 182 248 248 ASP ASP B . n B 1 183 PRO 183 249 249 PRO PRO B . n B 1 184 GLN 184 250 250 GLN GLN B . n B 1 185 HIS 185 251 251 HIS HIS B . n B 1 186 TYR 186 252 252 TYR TYR B . n B 1 187 GLU 187 253 253 GLU GLU B . n B 1 188 GLY 188 254 254 GLY GLY B . n B 1 189 ASN 189 255 255 ASN ASN B . n B 1 190 PHE 190 256 256 PHE PHE B . n B 1 191 HIS 191 257 257 HIS HIS B . n B 1 192 TYR 192 258 258 TYR TYR B . n B 1 193 ILE 193 259 259 ILE ILE B . n B 1 194 ASN 194 260 260 ASN ASN B . n B 1 195 LEU 195 261 261 LEU LEU B . n B 1 196 ILE 196 262 262 ILE ILE B . n B 1 197 LYS 197 263 263 LYS LYS B . n B 1 198 THR 198 264 264 THR THR B . n B 1 199 GLY 199 265 265 GLY GLY B . n B 1 200 VAL 200 266 266 VAL VAL B . n B 1 201 TRP 201 267 267 TRP TRP B . n B 1 202 GLN 202 268 268 GLN GLN B . n B 1 203 ILE 203 269 269 ILE ILE B . n B 1 204 GLN 204 270 270 GLN GLN B . n B 1 205 MET 205 271 271 MET MET B . n B 1 206 LYS 206 272 272 LYS LYS B . n B 1 207 GLY 207 273 273 GLY GLY B . n B 1 208 VAL 208 274 274 VAL VAL B . n B 1 209 SER 209 275 275 SER SER B . n B 1 210 VAL 210 276 276 VAL VAL B . n B 1 211 GLY 211 277 277 GLY GLY B . n B 1 212 SER 212 278 278 SER SER B . n B 1 213 SER 213 279 279 SER SER B . n B 1 214 THR 214 280 280 THR THR B . n B 1 215 LEU 215 281 281 LEU LEU B . n B 1 216 LEU 216 282 282 LEU LEU B . n B 1 217 CYS 217 283 283 CYS CYS B . n B 1 218 GLU 218 284 284 GLU GLU B . n B 1 219 ASP 219 285 285 ASP ASP B . n B 1 220 GLY 220 286 286 GLY GLY B . n B 1 221 CYS 221 287 287 CYS CYS B . n B 1 222 LEU 222 288 288 LEU LEU B . n B 1 223 ALA 223 289 289 ALA ALA B . n B 1 224 LEU 224 290 290 LEU LEU B . n B 1 225 VAL 225 291 291 VAL VAL B . n B 1 226 ASP 226 292 292 ASP ASP B . n B 1 227 THR 227 293 293 THR THR B . n B 1 228 GLY 228 294 294 GLY GLY B . n B 1 229 ALA 229 295 295 ALA ALA B . n B 1 230 SER 230 296 296 SER SER B . n B 1 231 TYR 231 297 297 TYR TYR B . n B 1 232 ILE 232 298 298 ILE ILE B . n B 1 233 SER 233 299 299 SER SER B . n B 1 234 GLY 234 300 300 GLY GLY B . n B 1 235 SER 235 301 301 SER SER B . n B 1 236 THR 236 302 302 THR THR B . n B 1 237 SER 237 303 303 SER SER B . n B 1 238 SER 238 304 304 SER SER B . n B 1 239 ILE 239 305 305 ILE ILE B . n B 1 240 GLU 240 306 306 GLU GLU B . n B 1 241 LYS 241 307 307 LYS LYS B . n B 1 242 LEU 242 308 308 LEU LEU B . n B 1 243 MET 243 309 309 MET MET B . n B 1 244 GLU 244 310 310 GLU GLU B . n B 1 245 ALA 245 311 311 ALA ALA B . n B 1 246 LEU 246 312 312 LEU LEU B . n B 1 247 GLY 247 313 313 GLY GLY B . n B 1 248 ALA 248 314 314 ALA ALA B . n B 1 249 LYS 249 315 315 LYS LYS B . n B 1 250 LYS 250 316 316 LYS LYS B . n B 1 251 ARG 251 317 317 ARG ARG B . n B 1 252 LEU 252 318 318 LEU LEU B . n B 1 253 PHE 253 319 319 PHE PHE B . n B 1 254 ASP 254 320 320 ASP ASP B . n B 1 255 TYR 255 321 321 TYR TYR B . n B 1 256 VAL 256 322 322 VAL VAL B . n B 1 257 VAL 257 323 323 VAL VAL B . n B 1 258 LYS 258 324 324 LYS LYS B . n B 1 259 CYS 259 325 325 CYS CYS B . n B 1 260 ASN 260 326 326 ASN ASN B . n B 1 261 GLU 261 327 327 GLU GLU B . n B 1 262 GLY 262 328 328 GLY GLY B . n B 1 263 PRO 263 329 329 PRO PRO B . n B 1 264 THR 264 330 330 THR THR B . n B 1 265 LEU 265 331 331 LEU LEU B . n B 1 266 PRO 266 332 332 PRO PRO B . n B 1 267 ASP 267 333 333 ASP ASP B . n B 1 268 ILE 268 334 334 ILE ILE B . n B 1 269 SER 269 335 335 SER SER B . n B 1 270 PHE 270 336 336 PHE PHE B . n B 1 271 HIS 271 337 337 HIS HIS B . n B 1 272 LEU 272 338 338 LEU LEU B . n B 1 273 GLY 273 339 339 GLY GLY B . n B 1 274 GLY 274 340 340 GLY GLY B . n B 1 275 LYS 275 341 341 LYS LYS B . n B 1 276 GLU 276 342 342 GLU GLU B . n B 1 277 TYR 277 343 343 TYR TYR B . n B 1 278 THR 278 344 344 THR THR B . n B 1 279 LEU 279 345 345 LEU LEU B . n B 1 280 THR 280 346 346 THR THR B . n B 1 281 SER 281 347 347 SER SER B . n B 1 282 ALA 282 348 348 ALA ALA B . n B 1 283 ASP 283 349 349 ASP ASP B . n B 1 284 TYR 284 350 350 TYR TYR B . n B 1 285 VAL 285 351 351 VAL VAL B . n B 1 286 PHE 286 352 352 PHE PHE B . n B 1 287 GLN 287 353 353 GLN GLN B . n B 1 288 GLU 288 354 354 GLU GLU B . n B 1 289 SER 289 355 355 SER SER B . n B 1 290 TYR 290 356 356 TYR TYR B . n B 1 291 SER 291 357 357 SER SER B . n B 1 292 SER 292 358 358 SER SER B . n B 1 293 LYS 293 359 359 LYS LYS B . n B 1 294 LYS 294 360 360 LYS LYS B . n B 1 295 LEU 295 361 361 LEU LEU B . n B 1 296 CYS 296 362 362 CYS CYS B . n B 1 297 THR 297 363 363 THR THR B . n B 1 298 LEU 298 364 364 LEU LEU B . n B 1 299 ALA 299 365 365 ALA ALA B . n B 1 300 ILE 300 366 366 ILE ILE B . n B 1 301 HIS 301 367 367 HIS HIS B . n B 1 302 ALA 302 368 368 ALA ALA B . n B 1 303 MET 303 369 369 MET MET B . n B 1 304 ASP 304 370 370 ASP ASP B . n B 1 305 ILE 305 371 371 ILE ILE B . n B 1 306 PRO 306 372 372 PRO PRO B . n B 1 307 PRO 307 373 373 PRO PRO B . n B 1 308 PRO 308 374 374 PRO PRO B . n B 1 309 THR 309 375 375 THR THR B . n B 1 310 GLY 310 376 376 GLY GLY B . n B 1 311 PRO 311 377 377 PRO PRO B . n B 1 312 THR 312 378 378 THR THR B . n B 1 313 TRP 313 379 379 TRP TRP B . n B 1 314 ALA 314 380 380 ALA ALA B . n B 1 315 LEU 315 381 381 LEU LEU B . n B 1 316 GLY 316 382 382 GLY GLY B . n B 1 317 ALA 317 383 383 ALA ALA B . n B 1 318 THR 318 384 384 THR THR B . n B 1 319 PHE 319 385 385 PHE PHE B . n B 1 320 ILE 320 386 386 ILE ILE B . n B 1 321 ARG 321 387 387 ARG ARG B . n B 1 322 LYS 322 388 388 LYS LYS B . n B 1 323 PHE 323 389 389 PHE PHE B . n B 1 324 TYR 324 390 390 TYR TYR B . n B 1 325 THR 325 391 391 THR THR B . n B 1 326 GLU 326 392 392 GLU GLU B . n B 1 327 PHE 327 393 393 PHE PHE B . n B 1 328 ASP 328 394 394 ASP ASP B . n B 1 329 ARG 329 395 395 ARG ARG B . n B 1 330 ARG 330 396 396 ARG ARG B . n B 1 331 ASN 331 397 397 ASN ASN B . n B 1 332 ASN 332 398 398 ASN ASN B . n B 1 333 ARG 333 399 399 ARG ARG B . n B 1 334 ILE 334 400 400 ILE ILE B . n B 1 335 GLY 335 401 401 GLY GLY B . n B 1 336 PHE 336 402 402 PHE PHE B . n B 1 337 ALA 337 403 403 ALA ALA B . n B 1 338 LEU 338 404 404 LEU LEU B . n B 1 339 ALA 339 405 405 ALA ALA B . n B 1 340 ARG 340 406 406 ARG ARG B . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code C 2 NAG 1 501 447 NAG NAG A . D 3 70Y 1 502 1 70Y 708 A . E 3 70Y 1 501 2 70Y 708 B . F 4 HOH 1 601 7 HOH HOH A . F 4 HOH 2 602 68 HOH HOH A . F 4 HOH 3 603 209 HOH HOH A . F 4 HOH 4 604 41 HOH HOH A . F 4 HOH 5 605 134 HOH HOH A . F 4 HOH 6 606 173 HOH HOH A . F 4 HOH 7 607 207 HOH HOH A . F 4 HOH 8 608 78 HOH HOH A . F 4 HOH 9 609 219 HOH HOH A . F 4 HOH 10 610 303 HOH HOH A . F 4 HOH 11 611 17 HOH HOH A . F 4 HOH 12 612 163 HOH HOH A . F 4 HOH 13 613 273 HOH HOH A . F 4 HOH 14 614 220 HOH HOH A . F 4 HOH 15 615 265 HOH HOH A . F 4 HOH 16 616 175 HOH HOH A . F 4 HOH 17 617 12 HOH HOH A . F 4 HOH 18 618 193 HOH HOH A . F 4 HOH 19 619 2 HOH HOH A . F 4 HOH 20 620 3 HOH HOH A . F 4 HOH 21 621 4 HOH HOH A . F 4 HOH 22 622 6 HOH HOH A . F 4 HOH 23 623 10 HOH HOH A . F 4 HOH 24 624 13 HOH HOH A . F 4 HOH 25 625 19 HOH HOH A . F 4 HOH 26 626 21 HOH HOH A . F 4 HOH 27 627 28 HOH HOH A . F 4 HOH 28 628 33 HOH HOH A . F 4 HOH 29 629 34 HOH HOH A . F 4 HOH 30 630 35 HOH HOH A . F 4 HOH 31 631 36 HOH HOH A . F 4 HOH 32 632 37 HOH HOH A . F 4 HOH 33 633 40 HOH HOH A . F 4 HOH 34 634 42 HOH HOH A . F 4 HOH 35 635 43 HOH HOH A . F 4 HOH 36 636 47 HOH HOH A . F 4 HOH 37 637 49 HOH HOH A . F 4 HOH 38 638 50 HOH HOH A . F 4 HOH 39 639 51 HOH HOH A . F 4 HOH 40 640 52 HOH HOH A . F 4 HOH 41 641 53 HOH HOH A . F 4 HOH 42 642 56 HOH HOH A . F 4 HOH 43 643 57 HOH HOH A . F 4 HOH 44 644 64 HOH HOH A . F 4 HOH 45 645 65 HOH HOH A . F 4 HOH 46 646 66 HOH HOH A . F 4 HOH 47 647 69 HOH HOH A . F 4 HOH 48 648 70 HOH HOH A . F 4 HOH 49 649 72 HOH HOH A . F 4 HOH 50 650 75 HOH HOH A . F 4 HOH 51 651 79 HOH HOH A . F 4 HOH 52 652 80 HOH HOH A . F 4 HOH 53 653 83 HOH HOH A . F 4 HOH 54 654 84 HOH HOH A . F 4 HOH 55 655 87 HOH HOH A . F 4 HOH 56 656 88 HOH HOH A . F 4 HOH 57 657 89 HOH HOH A . F 4 HOH 58 658 90 HOH HOH A . F 4 HOH 59 659 94 HOH HOH A . F 4 HOH 60 660 95 HOH HOH A . F 4 HOH 61 661 99 HOH HOH A . F 4 HOH 62 662 101 HOH HOH A . F 4 HOH 63 663 102 HOH HOH A . F 4 HOH 64 664 105 HOH HOH A . F 4 HOH 65 665 106 HOH HOH A . F 4 HOH 66 666 108 HOH HOH A . F 4 HOH 67 667 109 HOH HOH A . F 4 HOH 68 668 112 HOH HOH A . F 4 HOH 69 669 115 HOH HOH A . F 4 HOH 70 670 117 HOH HOH A . F 4 HOH 71 671 118 HOH HOH A . F 4 HOH 72 672 122 HOH HOH A . F 4 HOH 73 673 124 HOH HOH A . F 4 HOH 74 674 126 HOH HOH A . F 4 HOH 75 675 128 HOH HOH A . F 4 HOH 76 676 135 HOH HOH A . F 4 HOH 77 677 136 HOH HOH A . F 4 HOH 78 678 137 HOH HOH A . F 4 HOH 79 679 138 HOH HOH A . F 4 HOH 80 680 156 HOH HOH A . F 4 HOH 81 681 159 HOH HOH A . F 4 HOH 82 682 166 HOH HOH A . F 4 HOH 83 683 172 HOH HOH A . F 4 HOH 84 684 174 HOH HOH A . F 4 HOH 85 685 179 HOH HOH A . F 4 HOH 86 686 184 HOH HOH A . F 4 HOH 87 687 186 HOH HOH A . F 4 HOH 88 688 192 HOH HOH A . F 4 HOH 89 689 194 HOH HOH A . F 4 HOH 90 690 195 HOH HOH A . F 4 HOH 91 691 196 HOH HOH A . F 4 HOH 92 692 200 HOH HOH A . F 4 HOH 93 693 201 HOH HOH A . F 4 HOH 94 694 205 HOH HOH A . F 4 HOH 95 695 214 HOH HOH A . F 4 HOH 96 696 218 HOH HOH A . F 4 HOH 97 697 225 HOH HOH A . F 4 HOH 98 698 231 HOH HOH A . F 4 HOH 99 699 236 HOH HOH A . F 4 HOH 100 700 238 HOH HOH A . F 4 HOH 101 701 241 HOH HOH A . F 4 HOH 102 702 244 HOH HOH A . F 4 HOH 103 703 248 HOH HOH A . F 4 HOH 104 704 252 HOH HOH A . F 4 HOH 105 705 264 HOH HOH A . F 4 HOH 106 706 268 HOH HOH A . F 4 HOH 107 707 278 HOH HOH A . F 4 HOH 108 708 295 HOH HOH A . F 4 HOH 109 709 298 HOH HOH A . F 4 HOH 110 710 312 HOH HOH A . F 4 HOH 111 711 314 HOH HOH A . F 4 HOH 112 712 315 HOH HOH A . F 4 HOH 113 713 316 HOH HOH A . F 4 HOH 114 714 317 HOH HOH A . F 4 HOH 115 715 318 HOH HOH A . F 4 HOH 116 716 320 HOH HOH A . F 4 HOH 117 717 321 HOH HOH A . F 4 HOH 118 718 322 HOH HOH A . F 4 HOH 119 719 323 HOH HOH A . F 4 HOH 120 720 331 HOH HOH A . G 4 HOH 1 601 91 HOH HOH B . G 4 HOH 2 602 54 HOH HOH B . G 4 HOH 3 603 20 HOH HOH B . G 4 HOH 4 604 86 HOH HOH B . G 4 HOH 5 605 324 HOH HOH B . G 4 HOH 6 606 123 HOH HOH B . G 4 HOH 7 607 114 HOH HOH B . G 4 HOH 8 608 279 HOH HOH B . G 4 HOH 9 609 240 HOH HOH B . G 4 HOH 10 610 55 HOH HOH B . G 4 HOH 11 611 116 HOH HOH B . G 4 HOH 12 612 206 HOH HOH B . G 4 HOH 13 613 18 HOH HOH B . G 4 HOH 14 614 96 HOH HOH B . G 4 HOH 15 615 292 HOH HOH B . G 4 HOH 16 616 307 HOH HOH B . G 4 HOH 17 617 197 HOH HOH B . G 4 HOH 18 618 5 HOH HOH B . G 4 HOH 19 619 9 HOH HOH B . G 4 HOH 20 620 11 HOH HOH B . G 4 HOH 21 621 23 HOH HOH B . G 4 HOH 22 622 24 HOH HOH B . G 4 HOH 23 623 25 HOH HOH B . G 4 HOH 24 624 27 HOH HOH B . G 4 HOH 25 625 38 HOH HOH B . G 4 HOH 26 626 39 HOH HOH B . G 4 HOH 27 627 45 HOH HOH B . G 4 HOH 28 628 46 HOH HOH B . G 4 HOH 29 629 48 HOH HOH B . G 4 HOH 30 630 60 HOH HOH B . G 4 HOH 31 631 61 HOH HOH B . G 4 HOH 32 632 62 HOH HOH B . G 4 HOH 33 633 63 HOH HOH B . G 4 HOH 34 634 82 HOH HOH B . G 4 HOH 35 635 92 HOH HOH B . G 4 HOH 36 636 97 HOH HOH B . G 4 HOH 37 637 98 HOH HOH B . G 4 HOH 38 638 103 HOH HOH B . G 4 HOH 39 639 104 HOH HOH B . G 4 HOH 40 640 110 HOH HOH B . G 4 HOH 41 641 129 HOH HOH B . G 4 HOH 42 642 130 HOH HOH B . G 4 HOH 43 643 145 HOH HOH B . G 4 HOH 44 644 150 HOH HOH B . G 4 HOH 45 645 152 HOH HOH B . G 4 HOH 46 646 158 HOH HOH B . G 4 HOH 47 647 161 HOH HOH B . G 4 HOH 48 648 164 HOH HOH B . G 4 HOH 49 649 165 HOH HOH B . G 4 HOH 50 650 176 HOH HOH B . G 4 HOH 51 651 178 HOH HOH B . G 4 HOH 52 652 180 HOH HOH B . G 4 HOH 53 653 181 HOH HOH B . G 4 HOH 54 654 182 HOH HOH B . G 4 HOH 55 655 190 HOH HOH B . G 4 HOH 56 656 198 HOH HOH B . G 4 HOH 57 657 199 HOH HOH B . G 4 HOH 58 658 202 HOH HOH B . G 4 HOH 59 659 208 HOH HOH B . G 4 HOH 60 660 217 HOH HOH B . G 4 HOH 61 661 224 HOH HOH B . G 4 HOH 62 662 227 HOH HOH B . G 4 HOH 63 663 230 HOH HOH B . G 4 HOH 64 664 233 HOH HOH B . G 4 HOH 65 665 234 HOH HOH B . G 4 HOH 66 666 280 HOH HOH B . G 4 HOH 67 667 281 HOH HOH B . G 4 HOH 68 668 296 HOH HOH B . G 4 HOH 69 669 297 HOH HOH B . G 4 HOH 70 670 299 HOH HOH B . G 4 HOH 71 671 300 HOH HOH B . G 4 HOH 72 672 302 HOH HOH B . G 4 HOH 73 673 304 HOH HOH B . G 4 HOH 74 674 305 HOH HOH B . G 4 HOH 75 675 308 HOH HOH B . G 4 HOH 76 676 309 HOH HOH B . G 4 HOH 77 677 310 HOH HOH B . G 4 HOH 78 678 311 HOH HOH B . G 4 HOH 79 679 313 HOH HOH B . G 4 HOH 80 680 319 HOH HOH B . G 4 HOH 81 681 325 HOH HOH B . G 4 HOH 82 682 326 HOH HOH B . G 4 HOH 83 683 327 HOH HOH B . G 4 HOH 84 684 328 HOH HOH B . G 4 HOH 85 685 329 HOH HOH B . G 4 HOH 86 686 330 HOH HOH B . G 4 HOH 87 687 332 HOH HOH B . # loop_ _pdbx_struct_assembly.id _pdbx_struct_assembly.details _pdbx_struct_assembly.method_details _pdbx_struct_assembly.oligomeric_details _pdbx_struct_assembly.oligomeric_count 1 author_defined_assembly ? monomeric 1 2 author_defined_assembly ? monomeric 1 3 software_defined_assembly PISA hexameric 6 4 software_defined_assembly PISA trimeric 3 5 software_defined_assembly PISA trimeric 3 # loop_ _pdbx_struct_assembly_gen.assembly_id _pdbx_struct_assembly_gen.oper_expression _pdbx_struct_assembly_gen.asym_id_list 1 1 A,C,D,F 2 1 B,E,G 3 1,2,3 A,B,C,D,E,F,G 4 1,2,3 A,C,D,F 5 1,2,3 B,E,G # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 3 'ABSA (A^2)' 14110 ? 3 MORE -57 ? 3 'SSA (A^2)' 73070 ? 4 'ABSA (A^2)' 3990 ? 4 MORE -19 ? 4 'SSA (A^2)' 40690 ? 5 'ABSA (A^2)' 3950 ? 5 MORE -31 ? 5 'SSA (A^2)' 38550 ? # loop_ _pdbx_struct_oper_list.id _pdbx_struct_oper_list.type _pdbx_struct_oper_list.name _pdbx_struct_oper_list.symmetry_operation _pdbx_struct_oper_list.matrix[1][1] _pdbx_struct_oper_list.matrix[1][2] _pdbx_struct_oper_list.matrix[1][3] _pdbx_struct_oper_list.vector[1] _pdbx_struct_oper_list.matrix[2][1] _pdbx_struct_oper_list.matrix[2][2] _pdbx_struct_oper_list.matrix[2][3] _pdbx_struct_oper_list.vector[2] _pdbx_struct_oper_list.matrix[3][1] _pdbx_struct_oper_list.matrix[3][2] _pdbx_struct_oper_list.matrix[3][3] _pdbx_struct_oper_list.vector[3] 1 'identity operation' 1_555 x,y,z 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 2 'crystal symmetry operation' 5_555 z,x,y 0.0000000000 0.0000000000 1.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 3 'crystal symmetry operation' 9_555 y,z,x 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 # _pdbx_struct_special_symmetry.id 1 _pdbx_struct_special_symmetry.PDB_model_num 1 _pdbx_struct_special_symmetry.auth_asym_id A _pdbx_struct_special_symmetry.auth_comp_id HOH _pdbx_struct_special_symmetry.auth_seq_id 618 _pdbx_struct_special_symmetry.PDB_ins_code ? _pdbx_struct_special_symmetry.label_asym_id F _pdbx_struct_special_symmetry.label_comp_id HOH _pdbx_struct_special_symmetry.label_seq_id . # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2015-02-18 2 'Structure model' 1 1 2016-03-16 3 'Structure model' 1 2 2017-11-22 4 'Structure model' 1 3 2018-04-18 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Data collection' 2 3 'Structure model' 'Derived calculations' 3 3 'Structure model' 'Refinement description' 4 4 'Structure model' 'Data collection' 5 4 'Structure model' 'Database references' # loop_ _pdbx_audit_revision_category.ordinal _pdbx_audit_revision_category.revision_ordinal _pdbx_audit_revision_category.data_content_type _pdbx_audit_revision_category.category 1 3 'Structure model' pdbx_struct_oper_list 2 3 'Structure model' software 3 4 'Structure model' citation 4 4 'Structure model' citation_author # loop_ _pdbx_audit_revision_item.ordinal _pdbx_audit_revision_item.revision_ordinal _pdbx_audit_revision_item.data_content_type _pdbx_audit_revision_item.item 1 3 'Structure model' '_pdbx_struct_oper_list.symmetry_operation' 2 4 'Structure model' '_citation.journal_abbrev' 3 4 'Structure model' '_citation.journal_volume' 4 4 'Structure model' '_citation.page_first' 5 4 'Structure model' '_citation.page_last' 6 4 'Structure model' '_citation.pdbx_database_id_PubMed' 7 4 'Structure model' '_citation.title' # loop_ _software.citation_id _software.classification _software.compiler_name _software.compiler_version _software.contact_author _software.contact_author_email _software.date _software.description _software.dependencies _software.hardware _software.language _software.location _software.mods _software.name _software.os _software.os_version _software.type _software.version _software.pdbx_ordinal ? refinement ? ? ? ? ? ? ? ? ? ? ? BUSTER-TNT ? ? ? 'BUSTER 2.11.4' 1 ? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? DENZO ? ? ? . 2 ? 'data scaling' ? ? ? ? ? ? ? ? ? ? ? SCALEPACK ? ? ? . 3 ? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? 3.10 4 ? phasing ? ? ? ? ? ? ? ? ? ? ? AMoRE ? ? ? . 5 ? refinement ? ? ? ? ? ? ? ? ? ? ? BUSTER ? ? ? 2.11.4 6 # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 ASN A 71 ? ? -141.78 24.66 2 1 ARG A 119 ? ? -69.18 0.36 3 1 ASN A 141 ? ? -132.40 -65.58 4 1 SER A 278 ? ? -109.95 -61.34 5 1 ARG A 317 ? ? -120.32 -169.97 6 1 ALA A 365 ? ? -88.85 36.02 7 1 ASN B 141 ? ? -132.99 -64.24 8 1 GLN B 236 ? ? -96.92 30.86 9 1 THR B 280 ? ? -72.54 -80.93 10 1 LEU B 281 ? ? 78.06 -30.34 11 1 ARG B 317 ? ? -68.83 -98.15 12 1 LEU B 318 ? ? -123.94 -51.06 13 1 ALA B 365 ? ? -82.57 30.20 # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 Y 1 A LYS 220 ? CG ? A LYS 154 CG 2 1 Y 1 A LYS 220 ? CD ? A LYS 154 CD 3 1 Y 1 A LYS 220 ? CE ? A LYS 154 CE 4 1 Y 1 A LYS 220 ? NZ ? A LYS 154 NZ 5 1 Y 1 A GLN 236 ? CG ? A GLN 170 CG 6 1 Y 1 A GLN 236 ? CD ? A GLN 170 CD 7 1 Y 1 A GLN 236 ? OE1 ? A GLN 170 OE1 8 1 Y 1 A GLN 236 ? NE2 ? A GLN 170 NE2 9 1 Y 1 A GLN 250 ? CG ? A GLN 184 CG 10 1 Y 1 A GLN 250 ? CD ? A GLN 184 CD 11 1 Y 1 A GLN 250 ? OE1 ? A GLN 184 OE1 12 1 Y 1 A GLN 250 ? NE2 ? A GLN 184 NE2 13 1 Y 1 A LYS 315 ? CG ? A LYS 249 CG 14 1 Y 1 A LYS 315 ? CD ? A LYS 249 CD 15 1 Y 1 A LYS 315 ? CE ? A LYS 249 CE 16 1 Y 1 A LYS 315 ? NZ ? A LYS 249 NZ 17 1 Y 1 A LYS 341 ? CG ? A LYS 275 CG 18 1 Y 1 A LYS 341 ? CD ? A LYS 275 CD 19 1 Y 1 A LYS 341 ? CE ? A LYS 275 CE 20 1 Y 1 A LYS 341 ? NZ ? A LYS 275 NZ 21 1 Y 1 A LYS 359 ? CG ? A LYS 293 CG 22 1 Y 1 A LYS 359 ? CD ? A LYS 293 CD 23 1 Y 1 A LYS 359 ? CE ? A LYS 293 CE 24 1 Y 1 A LYS 359 ? NZ ? A LYS 293 NZ 25 1 Y 1 A LYS 360 ? CG ? A LYS 294 CG 26 1 Y 1 A LYS 360 ? CD ? A LYS 294 CD 27 1 Y 1 A LYS 360 ? CE ? A LYS 294 CE 28 1 Y 1 A LYS 360 ? NZ ? A LYS 294 NZ 29 1 Y 1 A ARG 396 ? CD ? A ARG 330 CD 30 1 Y 1 A ARG 396 ? NE ? A ARG 330 NE 31 1 Y 1 A ARG 396 ? CZ ? A ARG 330 CZ 32 1 Y 1 A ARG 396 ? NH1 ? A ARG 330 NH1 33 1 Y 1 A ARG 396 ? NH2 ? A ARG 330 NH2 34 1 Y 1 B ARG 119 ? CG ? B ARG 53 CG 35 1 Y 1 B ARG 119 ? CD ? B ARG 53 CD 36 1 Y 1 B ARG 119 ? NE ? B ARG 53 NE 37 1 Y 1 B ARG 119 ? CZ ? B ARG 53 CZ 38 1 Y 1 B ARG 119 ? NH1 ? B ARG 53 NH1 39 1 Y 1 B ARG 119 ? NH2 ? B ARG 53 NH2 40 1 Y 1 B TYR 126 ? CG ? B TYR 60 CG 41 1 Y 1 B TYR 126 ? CD1 ? B TYR 60 CD1 42 1 Y 1 B TYR 126 ? CD2 ? B TYR 60 CD2 43 1 Y 1 B TYR 126 ? CE1 ? B TYR 60 CE1 44 1 Y 1 B TYR 126 ? CE2 ? B TYR 60 CE2 45 1 Y 1 B TYR 126 ? CZ ? B TYR 60 CZ 46 1 Y 1 B TYR 126 ? OH ? B TYR 60 OH 47 1 Y 1 B LYS 139 ? CG ? B LYS 73 CG 48 1 Y 1 B LYS 139 ? CD ? B LYS 73 CD 49 1 Y 1 B LYS 139 ? CE ? B LYS 73 CE 50 1 Y 1 B LYS 139 ? NZ ? B LYS 73 NZ 51 1 Y 1 B GLU 144 ? CG ? B GLU 78 CG 52 1 Y 1 B GLU 144 ? CD ? B GLU 78 CD 53 1 Y 1 B GLU 144 ? OE1 ? B GLU 78 OE1 54 1 Y 1 B GLU 144 ? OE2 ? B GLU 78 OE2 55 1 Y 1 B ARG 148 ? CG ? B ARG 82 CG 56 1 Y 1 B ARG 148 ? CD ? B ARG 82 CD 57 1 Y 1 B ARG 148 ? NE ? B ARG 82 NE 58 1 Y 1 B ARG 148 ? CZ ? B ARG 82 CZ 59 1 Y 1 B ARG 148 ? NH1 ? B ARG 82 NH1 60 1 Y 1 B ARG 148 ? NH2 ? B ARG 82 NH2 61 1 Y 1 B GLU 179 ? CG ? B GLU 113 CG 62 1 Y 1 B GLU 179 ? CD ? B GLU 113 CD 63 1 Y 1 B GLU 179 ? OE1 ? B GLU 113 OE1 64 1 Y 1 B GLU 179 ? OE2 ? B GLU 113 OE2 65 1 Y 1 B ARG 205 ? CG ? B ARG 139 CG 66 1 Y 1 B ARG 205 ? CD ? B ARG 139 CD 67 1 Y 1 B ARG 205 ? NE ? B ARG 139 NE 68 1 Y 1 B ARG 205 ? CZ ? B ARG 139 CZ 69 1 Y 1 B ARG 205 ? NH1 ? B ARG 139 NH1 70 1 Y 1 B ARG 205 ? NH2 ? B ARG 139 NH2 71 1 Y 1 B LYS 220 ? CG ? B LYS 154 CG 72 1 Y 1 B LYS 220 ? CD ? B LYS 154 CD 73 1 Y 1 B LYS 220 ? CE ? B LYS 154 CE 74 1 Y 1 B LYS 220 ? NZ ? B LYS 154 NZ 75 1 Y 1 B LYS 272 ? CG ? B LYS 206 CG 76 1 Y 1 B LYS 272 ? CD ? B LYS 206 CD 77 1 Y 1 B LYS 272 ? CE ? B LYS 206 CE 78 1 Y 1 B LYS 272 ? NZ ? B LYS 206 NZ 79 1 Y 1 B LEU 281 ? CG ? B LEU 215 CG 80 1 Y 1 B LEU 281 ? CD1 ? B LEU 215 CD1 81 1 Y 1 B LEU 281 ? CD2 ? B LEU 215 CD2 82 1 Y 1 B GLU 284 ? CG ? B GLU 218 CG 83 1 Y 1 B GLU 284 ? CD ? B GLU 218 CD 84 1 Y 1 B GLU 284 ? OE1 ? B GLU 218 OE1 85 1 Y 1 B GLU 284 ? OE2 ? B GLU 218 OE2 86 1 Y 1 B LYS 315 ? CG ? B LYS 249 CG 87 1 Y 1 B LYS 315 ? CD ? B LYS 249 CD 88 1 Y 1 B LYS 315 ? CE ? B LYS 249 CE 89 1 Y 1 B LYS 315 ? NZ ? B LYS 249 NZ 90 1 Y 1 B LYS 341 ? CG ? B LYS 275 CG 91 1 Y 1 B LYS 341 ? CD ? B LYS 275 CD 92 1 Y 1 B LYS 341 ? CE ? B LYS 275 CE 93 1 Y 1 B LYS 341 ? NZ ? B LYS 275 NZ 94 1 Y 1 B GLU 354 ? CG ? B GLU 288 CG 95 1 Y 1 B GLU 354 ? CD ? B GLU 288 CD 96 1 Y 1 B GLU 354 ? OE1 ? B GLU 288 OE1 97 1 Y 1 B GLU 354 ? OE2 ? B GLU 288 OE2 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A LEU 67 ? A LEU 1 2 1 Y 1 B GLU 233 ? B GLU 167 3 1 Y 1 B ASN 234 ? B ASN 168 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 '(2Z,6S)-2-imino-6-methyl-3-{3-[(4R)-2-oxo-4-phenylpyrrolidin-1-yl]benzyl}-6-(propan-2-yl)tetrahydropyrimidin-4(1H)-one' 70Y 4 water HOH #