data_4RYG # _entry.id 4RYG # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code RCSB RCSB087951 PDB 4RYG WWPDB D_1000087951 # _pdbx_database_related.db_name PDB _pdbx_database_related.db_id 4RYC _pdbx_database_related.details . _pdbx_database_related.content_type unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 4RYG _pdbx_database_status.recvd_initial_deposition_date 2014-12-15 _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry ? _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? _pdbx_database_status.pdb_format_compatible Y # _audit_author.name 'Ostermann, N.' _audit_author.pdbx_ordinal 1 # _citation.id primary _citation.title ;trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: Prime site exploration using an amino linker. ; _citation.journal_abbrev Bioorg.Med.Chem.Lett. _citation.journal_volume 25 _citation.page_first 1782 _citation.page_last 1786 _citation.year 2015 _citation.journal_id_ASTM BMCLE8 _citation.country UK _citation.journal_id_ISSN 0960-894X _citation.journal_id_CSD 1127 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 25782742 _citation.pdbx_database_id_DOI 10.1016/j.bmcl.2015.02.039 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Lorthiois, E.' 1 primary 'Cumin, F.' 2 primary 'Ehrhardt, C.' 3 primary 'Kosaka, T.' 4 primary 'Sellner, H.' 5 primary 'Ostermann, N.' 6 primary 'Francotte, E.' 7 primary 'Wagner, T.' 8 primary 'Maibaum, J.' 9 # _cell.entry_id 4RYG _cell.length_a 141.674 _cell.length_b 141.674 _cell.length_c 141.674 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 90.00 _cell.Z_PDB 24 _cell.pdbx_unique_axis ? _cell.length_a_esd ? _cell.length_b_esd ? _cell.length_c_esd ? _cell.angle_alpha_esd ? _cell.angle_beta_esd ? _cell.angle_gamma_esd ? # _symmetry.entry_id 4RYG _symmetry.space_group_name_H-M 'P 21 3' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 198 _symmetry.space_group_name_Hall ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man Renin 37267.008 2 3.4.23.15 ? ? ? 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 2 ? ? ? ? 3 non-polymer syn 'N-({(3S,4S)-4-[(benzylsulfonyl)amino]pyrrolidin-3-yl}methyl)-4-methoxy-3-(3-methoxypropoxy)-N-(propan-2-yl)benzamide' 533.680 2 ? ? ? ? 4 non-polymer syn 'SULFATE ION' 96.063 1 ? ? ? ? 5 non-polymer syn 'DIMETHYL SULFOXIDE' 78.133 2 ? ? ? ? 6 water nat water 18.015 149 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name Angiotensinogenase # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELT LRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF YYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE KLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFI RKFYTEFDRRNNRIGFALAR ; _entity_poly.pdbx_seq_one_letter_code_can ;LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELT LRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF YYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE KLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFI RKFYTEFDRRNNRIGFALAR ; _entity_poly.pdbx_strand_id A,B _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 LEU n 1 2 THR n 1 3 LEU n 1 4 GLY n 1 5 ASN n 1 6 THR n 1 7 THR n 1 8 SER n 1 9 SER n 1 10 VAL n 1 11 ILE n 1 12 LEU n 1 13 THR n 1 14 ASN n 1 15 TYR n 1 16 MET n 1 17 ASP n 1 18 THR n 1 19 GLN n 1 20 TYR n 1 21 TYR n 1 22 GLY n 1 23 GLU n 1 24 ILE n 1 25 GLY n 1 26 ILE n 1 27 GLY n 1 28 THR n 1 29 PRO n 1 30 PRO n 1 31 GLN n 1 32 THR n 1 33 PHE n 1 34 LYS n 1 35 VAL n 1 36 VAL n 1 37 PHE n 1 38 ASP n 1 39 THR n 1 40 GLY n 1 41 SER n 1 42 SER n 1 43 ASN n 1 44 VAL n 1 45 TRP n 1 46 VAL n 1 47 PRO n 1 48 SER n 1 49 SER n 1 50 LYS n 1 51 CYS n 1 52 SER n 1 53 ARG n 1 54 LEU n 1 55 TYR n 1 56 THR n 1 57 ALA n 1 58 CYS n 1 59 VAL n 1 60 TYR n 1 61 HIS n 1 62 LYS n 1 63 LEU n 1 64 PHE n 1 65 ASP n 1 66 ALA n 1 67 SER n 1 68 ASP n 1 69 SER n 1 70 SER n 1 71 SER n 1 72 TYR n 1 73 LYS n 1 74 HIS n 1 75 ASN n 1 76 GLY n 1 77 THR n 1 78 GLU n 1 79 LEU n 1 80 THR n 1 81 LEU n 1 82 ARG n 1 83 TYR n 1 84 SER n 1 85 THR n 1 86 GLY n 1 87 THR n 1 88 VAL n 1 89 SER n 1 90 GLY n 1 91 PHE n 1 92 LEU n 1 93 SER n 1 94 GLN n 1 95 ASP n 1 96 ILE n 1 97 ILE n 1 98 THR n 1 99 VAL n 1 100 GLY n 1 101 GLY n 1 102 ILE n 1 103 THR n 1 104 VAL n 1 105 THR n 1 106 GLN n 1 107 MET n 1 108 PHE n 1 109 GLY n 1 110 GLU n 1 111 VAL n 1 112 THR n 1 113 GLU n 1 114 MET n 1 115 PRO n 1 116 ALA n 1 117 LEU n 1 118 PRO n 1 119 PHE n 1 120 MET n 1 121 LEU n 1 122 ALA n 1 123 GLU n 1 124 PHE n 1 125 ASP n 1 126 GLY n 1 127 VAL n 1 128 VAL n 1 129 GLY n 1 130 MET n 1 131 GLY n 1 132 PHE n 1 133 ILE n 1 134 GLU n 1 135 GLN n 1 136 ALA n 1 137 ILE n 1 138 GLY n 1 139 ARG n 1 140 VAL n 1 141 THR n 1 142 PRO n 1 143 ILE n 1 144 PHE n 1 145 ASP n 1 146 ASN n 1 147 ILE n 1 148 ILE n 1 149 SER n 1 150 GLN n 1 151 GLY n 1 152 VAL n 1 153 LEU n 1 154 LYS n 1 155 GLU n 1 156 ASP n 1 157 VAL n 1 158 PHE n 1 159 SER n 1 160 PHE n 1 161 TYR n 1 162 TYR n 1 163 ASN n 1 164 ARG n 1 165 ASP n 1 166 SER n 1 167 GLU n 1 168 ASN n 1 169 SER n 1 170 GLN n 1 171 SER n 1 172 LEU n 1 173 GLY n 1 174 GLY n 1 175 GLN n 1 176 ILE n 1 177 VAL n 1 178 LEU n 1 179 GLY n 1 180 GLY n 1 181 SER n 1 182 ASP n 1 183 PRO n 1 184 GLN n 1 185 HIS n 1 186 TYR n 1 187 GLU n 1 188 GLY n 1 189 ASN n 1 190 PHE n 1 191 HIS n 1 192 TYR n 1 193 ILE n 1 194 ASN n 1 195 LEU n 1 196 ILE n 1 197 LYS n 1 198 THR n 1 199 GLY n 1 200 VAL n 1 201 TRP n 1 202 GLN n 1 203 ILE n 1 204 GLN n 1 205 MET n 1 206 LYS n 1 207 GLY n 1 208 VAL n 1 209 SER n 1 210 VAL n 1 211 GLY n 1 212 SER n 1 213 SER n 1 214 THR n 1 215 LEU n 1 216 LEU n 1 217 CYS n 1 218 GLU n 1 219 ASP n 1 220 GLY n 1 221 CYS n 1 222 LEU n 1 223 ALA n 1 224 LEU n 1 225 VAL n 1 226 ASP n 1 227 THR n 1 228 GLY n 1 229 ALA n 1 230 SER n 1 231 TYR n 1 232 ILE n 1 233 SER n 1 234 GLY n 1 235 SER n 1 236 THR n 1 237 SER n 1 238 SER n 1 239 ILE n 1 240 GLU n 1 241 LYS n 1 242 LEU n 1 243 MET n 1 244 GLU n 1 245 ALA n 1 246 LEU n 1 247 GLY n 1 248 ALA n 1 249 LYS n 1 250 LYS n 1 251 ARG n 1 252 LEU n 1 253 PHE n 1 254 ASP n 1 255 TYR n 1 256 VAL n 1 257 VAL n 1 258 LYS n 1 259 CYS n 1 260 ASN n 1 261 GLU n 1 262 GLY n 1 263 PRO n 1 264 THR n 1 265 LEU n 1 266 PRO n 1 267 ASP n 1 268 ILE n 1 269 SER n 1 270 PHE n 1 271 HIS n 1 272 LEU n 1 273 GLY n 1 274 GLY n 1 275 LYS n 1 276 GLU n 1 277 TYR n 1 278 THR n 1 279 LEU n 1 280 THR n 1 281 SER n 1 282 ALA n 1 283 ASP n 1 284 TYR n 1 285 VAL n 1 286 PHE n 1 287 GLN n 1 288 GLU n 1 289 SER n 1 290 TYR n 1 291 SER n 1 292 SER n 1 293 LYS n 1 294 LYS n 1 295 LEU n 1 296 CYS n 1 297 THR n 1 298 LEU n 1 299 ALA n 1 300 ILE n 1 301 HIS n 1 302 ALA n 1 303 MET n 1 304 ASP n 1 305 ILE n 1 306 PRO n 1 307 PRO n 1 308 PRO n 1 309 THR n 1 310 GLY n 1 311 PRO n 1 312 THR n 1 313 TRP n 1 314 ALA n 1 315 LEU n 1 316 GLY n 1 317 ALA n 1 318 THR n 1 319 PHE n 1 320 ILE n 1 321 ARG n 1 322 LYS n 1 323 PHE n 1 324 TYR n 1 325 THR n 1 326 GLU n 1 327 PHE n 1 328 ASP n 1 329 ARG n 1 330 ARG n 1 331 ASN n 1 332 ASN n 1 333 ARG n 1 334 ILE n 1 335 GLY n 1 336 PHE n 1 337 ALA n 1 338 LEU n 1 339 ALA n 1 340 ARG n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name ? _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene ? _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Homo sapiens' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 9606 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'Cricetulus griseus' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 10029 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain ? _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type ? _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name ? _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code RENI_HUMAN _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELT LRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF YYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE KLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFI RKFYTEFDRRNNRIGFALAR ; _struct_ref.pdbx_align_begin 67 _struct_ref.pdbx_db_accession P00797 _struct_ref.pdbx_db_isoform ? # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 4RYG A 1 ? 340 ? P00797 67 ? 406 ? -5 326 2 1 4RYG B 1 ? 340 ? P00797 67 ? 406 ? -5 326 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight 3ZJ non-polymer . 'N-({(3S,4S)-4-[(benzylsulfonyl)amino]pyrrolidin-3-yl}methyl)-4-methoxy-3-(3-methoxypropoxy)-N-(propan-2-yl)benzamide' ? 'C27 H39 N3 O6 S' 533.680 ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 DMS non-polymer . 'DIMETHYL SULFOXIDE' ? 'C2 H6 O S' 78.133 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 SO4 non-polymer . 'SULFATE ION' ? 'O4 S -2' 96.063 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 4RYG _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 3.18 _exptl_crystal.density_percent_sol 61.31 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.temp 293 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 4 _exptl_crystal_grow.pdbx_details ;HANGING DROP, VAPOR DIFFUSION, 1 UL PROTEIN + 1 UL RESERVOIR; PROTEIN SOLUTION: 9.4 MG/ML RENIN, 12.5 MM TRIS PH 8, 25 MM NACL; RESERVOIR SOLUTION: 18% PEG4000, 50 MM NACITRATE PH 4.0, 600 MM NACL; SOAKING: DROP PLUS 2.5 UL RESERVOIR SOLUTION PLUS 10 MM INHIBITOR 54 AND 10% DMSO FOR 20 MIN; CRYO: SOAKING SOLUTION PLUS 15% GLYCEROL, VAPOR DIFFUSION, HANGING DROP, temperature 293K ; _exptl_crystal_grow.pdbx_pH_range ? # _diffrn.id 1 _diffrn.ambient_temp 100.0 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector MAR225/CCD _diffrn_detector.type MARRESEARCH _diffrn_detector.pdbx_collection_date 2005-02-18 _diffrn_detector.details ? # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator ? _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.97865 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'SLS BEAMLINE X10SA' _diffrn_source.pdbx_synchrotron_site SLS _diffrn_source.pdbx_synchrotron_beamline X10SA _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list 0.97865 # _reflns.entry_id 4RYG _reflns.observed_criterion_sigma_I ? _reflns.observed_criterion_sigma_F 0 _reflns.d_resolution_low 42.72 _reflns.d_resolution_high 2.65 _reflns.number_obs 27515 _reflns.number_all ? _reflns.percent_possible_obs 98.8 _reflns.pdbx_Rmerge_I_obs ? _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI ? _reflns.B_iso_Wilson_estimate 71.52 _reflns.pdbx_redundancy ? _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # _refine.entry_id 4RYG _refine.ls_number_reflns_obs 27443 _refine.ls_number_reflns_all ? _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F 0.0 _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 42.72 _refine.ls_d_res_high 2.65 _refine.ls_percent_reflns_obs 98.74 _refine.ls_R_factor_obs 0.1870 _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work 0.1829 _refine.ls_R_factor_R_free 0.2225 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 10.04 _refine.ls_number_reflns_R_free 2754 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc 0.9432 _refine.correlation_coeff_Fo_to_Fc_free 0.9164 _refine.B_iso_mean 57.42 _refine.aniso_B[1][1] 0.0000 _refine.aniso_B[2][2] 0.0000 _refine.aniso_B[3][3] 0.0000 _refine.aniso_B[1][2] 0.0000 _refine.aniso_B[1][3] 0.0000 _refine.aniso_B[2][3] 0.0000 _refine.solvent_model_details ? _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii ? _refine.pdbx_solvent_ion_probe_radii ? _refine.pdbx_solvent_shrinkage_radii ? _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details ? _refine.pdbx_starting_model ? _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values ? _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R ? _refine.pdbx_overall_ESU_R_Free ? _refine.overall_SU_ML ? _refine.pdbx_overall_phase_error ? _refine.overall_SU_B ? _refine.overall_SU_R_Cruickshank_DPI 0.475 _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_diffrn_id 1 _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_analyze.entry_id 4RYG _refine_analyze.Luzzati_coordinate_error_obs 0.309 _refine_analyze.Luzzati_sigma_a_obs ? _refine_analyze.Luzzati_d_res_low_obs ? _refine_analyze.Luzzati_coordinate_error_free ? _refine_analyze.Luzzati_sigma_a_free ? _refine_analyze.Luzzati_d_res_low_free ? _refine_analyze.number_disordered_residues ? _refine_analyze.occupancy_sum_hydrogen ? _refine_analyze.occupancy_sum_non_hydrogen ? _refine_analyze.pdbx_Luzzati_d_res_high_obs ? _refine_analyze.pdbx_refine_id 'X-RAY DIFFRACTION' # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 5178 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 115 _refine_hist.number_atoms_solvent 149 _refine_hist.number_atoms_total 5442 _refine_hist.d_res_high 2.65 _refine_hist.d_res_low 42.72 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_restraint_function _refine_ls_restr.pdbx_refine_id t_bond_d 0.010 ? 2.00 5420 HARMONIC 'X-RAY DIFFRACTION' t_angle_deg 1.19 ? 2.00 7359 HARMONIC 'X-RAY DIFFRACTION' t_dihedral_angle_d ? ? 2.00 1811 SINUSOIDAL 'X-RAY DIFFRACTION' t_incorr_chiral_ct ? ? ? ? ? 'X-RAY DIFFRACTION' t_pseud_angle ? ? ? ? ? 'X-RAY DIFFRACTION' t_trig_c_planes ? ? 2.00 110 HARMONIC 'X-RAY DIFFRACTION' t_gen_planes ? ? 5.00 791 HARMONIC 'X-RAY DIFFRACTION' t_it ? ? 20.00 5420 HARMONIC 'X-RAY DIFFRACTION' t_nbd ? ? ? ? ? 'X-RAY DIFFRACTION' t_omega_torsion 3.61 ? ? ? ? 'X-RAY DIFFRACTION' t_other_torsion 18.98 ? ? ? ? 'X-RAY DIFFRACTION' t_improper_torsion ? ? ? ? ? 'X-RAY DIFFRACTION' t_chiral_improper_torsion ? ? 5.00 723 SEMIHARMONIC 'X-RAY DIFFRACTION' t_sum_occupancies ? ? ? ? ? 'X-RAY DIFFRACTION' t_utility_distance ? ? ? ? ? 'X-RAY DIFFRACTION' t_utility_angle ? ? ? ? ? 'X-RAY DIFFRACTION' t_utility_torsion ? ? ? ? ? 'X-RAY DIFFRACTION' t_ideal_dist_contact ? ? 4.00 6046 SEMIHARMONIC 'X-RAY DIFFRACTION' # _refine_ls_shell.pdbx_total_number_of_bins_used 14 _refine_ls_shell.d_res_high 2.65 _refine_ls_shell.d_res_low 2.75 _refine_ls_shell.number_reflns_R_work 2512 _refine_ls_shell.R_factor_R_work 0.2284 _refine_ls_shell.percent_reflns_obs 98.74 _refine_ls_shell.R_factor_R_free 0.2968 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.percent_reflns_R_free 10.73 _refine_ls_shell.number_reflns_R_free 302 _refine_ls_shell.number_reflns_all 2814 _refine_ls_shell.R_factor_all 0.2357 _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' # _struct.entry_id 4RYG _struct.title ;RENIN IN COMPLEXED WITH N-({(3S,4S)-4-[(benzylsulfonyl)amino]pyrrolidin-3-yl}methyl)-4-methoxy-3-(3-methoxypropoxy)-N-(propan-2-yl)benzamide INHIBITOR ; _struct.pdbx_descriptor 'Renin (E.C.3.4.23.15)' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 4RYG _struct_keywords.pdbx_keywords 'HYDROLASE/HYDROLASE INHIBITOR' _struct_keywords.text 'HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 1 ? C N N 2 ? D N N 3 ? E N N 4 ? F N N 2 ? G N N 3 ? H N N 5 ? I N N 5 ? J N N 6 ? K N N 6 ? # _struct_biol.id 1 _struct_biol.details ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 TYR A 55 B TYR A 60 ? TYR A 47 TYR A 52 1 ? 6 HELX_P HELX_P2 2 ASP A 65 ? SER A 69 ? ASP A 57 SER A 61 5 ? 5 HELX_P HELX_P3 3 PRO A 115 ? MET A 120 ? PRO A 108 MET A 113 1 ? 6 HELX_P HELX_P4 4 PHE A 132 ? VAL A 140 ? PHE A 125 VAL A 133 5 ? 9 HELX_P HELX_P5 5 PRO A 142 ? GLN A 150 ? PRO A 135 GLN A 143 1 ? 9 HELX_P HELX_P6 6 ASP A 182 ? GLN A 184 ? ASP A 171 GLN A 173 5 ? 3 HELX_P HELX_P7 7 SER A 235 ? GLY A 247 ? SER A 224 GLY A 236 1 ? 13 HELX_P HELX_P8 8 ASN A 260 ? GLY A 262 ? ASN A 250 GLY A 252 5 ? 3 HELX_P HELX_P9 9 THR A 280 ? VAL A 285 ? THR A 270 VAL A 275 1 ? 6 HELX_P HELX_P10 10 GLY A 316 ? LYS A 322 ? GLY A 302 LYS A 308 1 ? 7 HELX_P HELX_P11 11 TYR B 55 B TYR B 60 ? TYR B 47 TYR B 52 1 ? 6 HELX_P HELX_P12 12 ASP B 65 ? SER B 69 ? ASP B 57 SER B 61 5 ? 5 HELX_P HELX_P13 13 PRO B 115 ? MET B 120 ? PRO B 108 MET B 113 1 ? 6 HELX_P HELX_P14 14 PHE B 132 ? VAL B 140 ? PHE B 125 VAL B 133 5 ? 9 HELX_P HELX_P15 15 PRO B 142 ? GLN B 150 ? PRO B 135 GLN B 143 1 ? 9 HELX_P HELX_P16 16 ASP B 182 ? GLN B 184 ? ASP B 171 GLN B 173 5 ? 3 HELX_P HELX_P17 17 SER B 235 ? GLY B 247 ? SER B 224 GLY B 236 1 ? 13 HELX_P HELX_P18 18 ASN B 260 ? LEU B 265 ? ASN B 250 LEU B 255 5 ? 6 HELX_P HELX_P19 19 THR B 280 ? VAL B 285 ? THR B 270 VAL B 275 1 ? 6 HELX_P HELX_P20 20 GLY B 316 ? LYS B 322 ? GLY B 302 LYS B 308 1 ? 7 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 51 SG ? ? ? 1_555 A CYS 58 SG ? ? A CYS 45 A CYS 50 1_555 ? ? ? ? ? ? ? 2.022 ? disulf2 disulf ? ? A CYS 217 SG ? ? ? 1_555 A CYS 221 SG ? ? A CYS 206 A CYS 210 1_555 ? ? ? ? ? ? ? 2.039 ? disulf3 disulf ? ? A CYS 259 SG ? ? ? 1_555 A CYS 296 SG ? ? A CYS 249 A CYS 282 1_555 ? ? ? ? ? ? ? 2.032 ? disulf4 disulf ? ? B CYS 51 SG ? ? ? 1_555 B CYS 58 SG ? ? B CYS 45 B CYS 50 1_555 ? ? ? ? ? ? ? 2.025 ? disulf5 disulf ? ? B CYS 217 SG ? ? ? 1_555 B CYS 221 SG ? ? B CYS 206 B CYS 210 1_555 ? ? ? ? ? ? ? 2.039 ? disulf6 disulf ? ? B CYS 259 SG ? ? ? 1_555 B CYS 296 SG ? ? B CYS 249 B CYS 282 1_555 ? ? ? ? ? ? ? 2.033 ? covale1 covale ? ? B ASN 75 ND2 ? ? ? 1_555 F NAG . C1 ? ? B ASN 67 B NAG 1000 1_555 ? ? ? ? ? ? ? 1.434 ? covale2 covale ? ? A ASN 75 ND2 ? ? ? 1_555 C NAG . C1 ? ? A ASN 67 A NAG 1000 1_555 ? ? ? ? ? ? ? 1.435 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 THR 28 A . ? THR 22 A PRO 29 A ? PRO 23 A 1 -2.14 2 LEU 117 A . ? LEU 110 A PRO 118 A ? PRO 111 A 1 11.28 3 PRO 307 A . ? PRO 293 A PRO 308 A ? PRO 294 A 1 5.97 4 GLY 310 A . ? GLY 296 A PRO 311 A ? PRO 297 A 1 -3.52 5 THR 28 B . ? THR 22 B PRO 29 B ? PRO 23 B 1 -2.95 6 LEU 117 B . ? LEU 110 B PRO 118 B ? PRO 111 B 1 4.06 7 PRO 307 B . ? PRO 293 B PRO 308 B ? PRO 294 B 1 8.06 8 GLY 310 B . ? GLY 296 B PRO 311 B ? PRO 297 B 1 -4.86 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 9 ? B ? 13 ? C ? 4 ? D ? 6 ? E ? 3 ? F ? 9 ? G ? 13 ? H ? 5 ? I ? 4 ? J ? 3 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? anti-parallel A 2 3 ? anti-parallel A 3 4 ? anti-parallel A 4 5 ? anti-parallel A 5 6 ? anti-parallel A 6 7 ? anti-parallel A 7 8 ? anti-parallel A 8 9 ? anti-parallel B 1 2 ? anti-parallel B 2 3 ? anti-parallel B 3 4 ? parallel B 4 5 ? anti-parallel B 5 6 ? parallel B 6 7 ? anti-parallel B 7 8 ? anti-parallel B 8 9 ? anti-parallel B 9 10 ? anti-parallel B 10 11 ? anti-parallel B 11 12 ? anti-parallel B 12 13 ? anti-parallel C 1 2 ? anti-parallel C 2 3 ? anti-parallel C 3 4 ? anti-parallel D 1 2 ? anti-parallel D 2 3 ? anti-parallel D 3 4 ? parallel D 4 5 ? anti-parallel D 5 6 ? parallel E 1 2 ? anti-parallel E 2 3 ? anti-parallel F 1 2 ? anti-parallel F 2 3 ? anti-parallel F 3 4 ? anti-parallel F 4 5 ? anti-parallel F 5 6 ? anti-parallel F 6 7 ? anti-parallel F 7 8 ? anti-parallel F 8 9 ? anti-parallel G 1 2 ? anti-parallel G 2 3 ? anti-parallel G 3 4 ? parallel G 4 5 ? anti-parallel G 5 6 ? parallel G 6 7 ? anti-parallel G 7 8 ? anti-parallel G 8 9 ? anti-parallel G 9 10 ? anti-parallel G 10 11 ? anti-parallel G 11 12 ? anti-parallel G 12 13 ? anti-parallel H 1 2 ? anti-parallel H 2 3 ? parallel H 3 4 ? anti-parallel H 4 5 ? parallel I 1 2 ? anti-parallel I 2 3 ? anti-parallel I 3 4 ? anti-parallel J 1 2 ? anti-parallel J 2 3 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 LYS A 73 ? TYR A 83 ? LYS A 65 TYR A 75 A 2 GLY A 86 ? VAL A 99 ? GLY A 78 VAL A 91 A 3 GLN A 19 ? ILE A 26 ? GLN A 13 ILE A 20 A 4 SER A 8 ? TYR A 15 ? SER A 2 TYR A 9 A 5 GLY A 174 ? LEU A 178 ? GLY A 163 LEU A 167 A 6 VAL A 157 ? TYR A 162 ? VAL A 150 TYR A 155 A 7 PHE A 323 ? ASP A 328 ? PHE A 309 ASP A 314 A 8 ARG A 333 ? ALA A 339 ? ARG A 319 ALA A 325 A 9 TYR A 186 ? ASN A 194 ? TYR A 175 ASN A 183 B 1 LYS A 73 ? TYR A 83 ? LYS A 65 TYR A 75 B 2 GLY A 86 ? VAL A 99 ? GLY A 78 VAL A 91 B 3 ILE A 102 ? GLU A 113 ? ILE A 94 GLU A 106 B 4 VAL A 44 ? PRO A 47 ? VAL A 38 PRO A 41 B 5 GLY A 126 ? GLY A 129 ? GLY A 119 GLY A 122 B 6 GLN A 31 ? ASP A 38 ? GLN A 25 ASP A 32 B 7 GLN A 19 ? ILE A 26 ? GLN A 13 ILE A 20 B 8 SER A 8 ? TYR A 15 ? SER A 2 TYR A 9 B 9 GLY A 174 ? LEU A 178 ? GLY A 163 LEU A 167 B 10 VAL A 157 ? TYR A 162 ? VAL A 150 TYR A 155 B 11 PHE A 323 ? ASP A 328 ? PHE A 309 ASP A 314 B 12 ARG A 333 ? ALA A 339 ? ARG A 319 ALA A 325 B 13 TYR A 186 ? ASN A 194 ? TYR A 175 ASN A 183 C 1 SER A 213 ? LEU A 216 ? SER A 202 LEU A 205 C 2 GLN A 202 ? VAL A 210 ? GLN A 191 VAL A 199 C 3 ILE A 268 ? LEU A 272 ? ILE A 258 LEU A 262 C 4 LYS A 275 ? LEU A 279 ? LYS A 265 LEU A 269 D 1 SER A 213 ? LEU A 216 ? SER A 202 LEU A 205 D 2 GLN A 202 ? VAL A 210 ? GLN A 191 VAL A 199 D 3 CYS A 221 ? VAL A 225 ? CYS A 210 VAL A 214 D 4 TRP A 313 ? LEU A 315 ? TRP A 299 LEU A 301 D 5 ILE A 232 ? GLY A 234 ? ILE A 221 GLY A 223 D 6 ILE A 300 ? ALA A 302 ? ILE A 286 ALA A 288 E 1 LYS A 249 ? LYS A 250 ? LYS A 238 LYS A 239 E 2 TYR A 255 ? LYS A 258 ? TYR A 245 LYS A 248 E 3 LEU A 295 D THR A 297 ? LEU A 281 THR A 283 F 1 LYS B 73 ? ARG B 82 ? LYS B 65 ARG B 74 F 2 THR B 87 ? VAL B 99 ? THR B 79 VAL B 91 F 3 GLN B 19 ? ILE B 26 ? GLN B 13 ILE B 20 F 4 SER B 8 ? TYR B 15 ? SER B 2 TYR B 9 F 5 GLY B 174 ? LEU B 178 ? GLY B 163 LEU B 167 F 6 VAL B 157 ? TYR B 162 ? VAL B 150 TYR B 155 F 7 PHE B 323 ? ASP B 328 ? PHE B 309 ASP B 314 F 8 ARG B 333 ? ALA B 339 ? ARG B 319 ALA B 325 F 9 TYR B 186 ? ASN B 194 ? TYR B 175 ASN B 183 G 1 LYS B 73 ? ARG B 82 ? LYS B 65 ARG B 74 G 2 THR B 87 ? VAL B 99 ? THR B 79 VAL B 91 G 3 ILE B 102 ? GLU B 113 ? ILE B 94 GLU B 106 G 4 VAL B 44 ? PRO B 47 ? VAL B 38 PRO B 41 G 5 GLY B 126 ? GLY B 129 ? GLY B 119 GLY B 122 G 6 GLN B 31 ? ASP B 38 ? GLN B 25 ASP B 32 G 7 GLN B 19 ? ILE B 26 ? GLN B 13 ILE B 20 G 8 SER B 8 ? TYR B 15 ? SER B 2 TYR B 9 G 9 GLY B 174 ? LEU B 178 ? GLY B 163 LEU B 167 G 10 VAL B 157 ? TYR B 162 ? VAL B 150 TYR B 155 G 11 PHE B 323 ? ASP B 328 ? PHE B 309 ASP B 314 G 12 ARG B 333 ? ALA B 339 ? ARG B 319 ALA B 325 G 13 TYR B 186 ? ASN B 194 ? TYR B 175 ASN B 183 H 1 GLN B 202 ? MET B 205 ? GLN B 191 MET B 194 H 2 CYS B 221 ? VAL B 225 ? CYS B 210 VAL B 214 H 3 TRP B 313 ? LEU B 315 ? TRP B 299 LEU B 301 H 4 ILE B 232 ? GLY B 234 ? ILE B 221 GLY B 223 H 5 ILE B 300 ? ALA B 302 ? ILE B 286 ALA B 288 I 1 SER B 213 ? LEU B 216 ? SER B 202 LEU B 205 I 2 GLY B 207 ? VAL B 210 ? GLY B 196 VAL B 199 I 3 ILE B 268 ? LEU B 272 ? ILE B 258 LEU B 262 I 4 LYS B 275 ? LEU B 279 ? LYS B 265 LEU B 269 J 1 LYS B 249 ? LYS B 250 ? LYS B 238 LYS B 239 J 2 TYR B 255 ? LYS B 258 ? TYR B 245 LYS B 248 J 3 LEU B 295 D THR B 297 ? LEU B 281 THR B 283 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 N GLY A 76 ? N GLY A 68 O LEU A 92 ? O LEU A 84 A 2 3 O THR A 98 ? O THR A 90 N GLY A 25 ? N GLY A 19 A 3 4 O GLN A 19 ? O GLN A 13 N TYR A 15 ? N TYR A 9 A 4 5 N SER A 8 ? N SER A 2 O LEU A 178 ? O LEU A 167 A 5 6 O VAL A 177 ? O VAL A 166 N SER A 159 ? N SER A 152 A 6 7 N PHE A 158 ? N PHE A 151 O PHE A 327 ? O PHE A 313 A 7 8 N GLU A 326 ? N GLU A 312 O GLY A 335 ? O GLY A 321 A 8 9 O ILE A 334 ? O ILE A 320 N ILE A 193 ? N ILE A 182 B 1 2 N GLY A 76 ? N GLY A 68 O LEU A 92 ? O LEU A 84 B 2 3 N PHE A 91 ? N PHE A 83 O GLU A 110 ? O GLU A 103 B 3 4 O GLY A 109 ? O GLY A 102 N VAL A 44 ? N VAL A 38 B 4 5 N TRP A 45 ? N TRP A 39 O VAL A 127 ? O VAL A 120 B 5 6 O VAL A 128 ? O VAL A 121 N VAL A 36 ? N VAL A 30 B 6 7 O VAL A 35 ? O VAL A 29 N GLY A 22 ? N GLY A 16 B 7 8 O GLN A 19 ? O GLN A 13 N TYR A 15 ? N TYR A 9 B 8 9 N SER A 8 ? N SER A 2 O LEU A 178 ? O LEU A 167 B 9 10 O VAL A 177 ? O VAL A 166 N SER A 159 ? N SER A 152 B 10 11 N PHE A 158 ? N PHE A 151 O PHE A 327 ? O PHE A 313 B 11 12 N GLU A 326 ? N GLU A 312 O GLY A 335 ? O GLY A 321 B 12 13 O ILE A 334 ? O ILE A 320 N ILE A 193 ? N ILE A 182 C 1 2 O LEU A 216 ? O LEU A 205 N VAL A 208 ? N VAL A 197 C 2 3 N GLY A 207 ? N GLY A 196 O HIS A 271 ? O HIS A 261 C 3 4 N ILE A 268 ? N ILE A 258 O LEU A 279 ? O LEU A 269 D 1 2 O LEU A 216 ? O LEU A 205 N VAL A 208 ? N VAL A 197 D 2 3 N MET A 205 ? N MET A 194 O CYS A 221 ? O CYS A 210 D 3 4 N LEU A 224 ? N LEU A 213 O LEU A 315 ? O LEU A 301 D 4 5 O ALA A 314 ? O ALA A 300 N SER A 233 ? N SER A 222 D 5 6 N ILE A 232 ? N ILE A 221 O HIS A 301 ? O HIS A 287 E 1 2 N LYS A 249 ? N LYS A 238 O VAL A 256 ? O VAL A 246 E 2 3 N VAL A 257 ? N VAL A 247 O CYS A 296 ? O CYS A 282 F 1 2 N GLY B 76 ? N GLY B 68 O LEU B 92 ? O LEU B 84 F 2 3 O THR B 98 ? O THR B 90 N GLY B 25 ? N GLY B 19 F 3 4 O GLN B 19 ? O GLN B 13 N TYR B 15 ? N TYR B 9 F 4 5 N SER B 8 ? N SER B 2 O LEU B 178 ? O LEU B 167 F 5 6 O VAL B 177 ? O VAL B 166 N SER B 159 ? N SER B 152 F 6 7 N PHE B 158 ? N PHE B 151 O PHE B 327 ? O PHE B 313 F 7 8 N GLU B 326 ? N GLU B 312 O GLY B 335 ? O GLY B 321 F 8 9 O LEU B 338 ? O LEU B 324 N GLU B 187 ? N GLU B 176 G 1 2 N GLY B 76 ? N GLY B 68 O LEU B 92 ? O LEU B 84 G 2 3 N PHE B 91 ? N PHE B 83 O GLU B 110 ? O GLU B 103 G 3 4 O GLY B 109 ? O GLY B 102 N VAL B 44 ? N VAL B 38 G 4 5 N TRP B 45 ? N TRP B 39 O VAL B 127 ? O VAL B 120 G 5 6 O VAL B 128 ? O VAL B 121 N VAL B 36 ? N VAL B 30 G 6 7 O VAL B 35 ? O VAL B 29 N GLY B 22 ? N GLY B 16 G 7 8 O GLN B 19 ? O GLN B 13 N TYR B 15 ? N TYR B 9 G 8 9 N SER B 8 ? N SER B 2 O LEU B 178 ? O LEU B 167 G 9 10 O VAL B 177 ? O VAL B 166 N SER B 159 ? N SER B 152 G 10 11 N PHE B 158 ? N PHE B 151 O PHE B 327 ? O PHE B 313 G 11 12 N GLU B 326 ? N GLU B 312 O GLY B 335 ? O GLY B 321 G 12 13 O LEU B 338 ? O LEU B 324 N GLU B 187 ? N GLU B 176 H 1 2 N MET B 205 ? N MET B 194 O CYS B 221 ? O CYS B 210 H 2 3 N LEU B 224 ? N LEU B 213 O LEU B 315 ? O LEU B 301 H 3 4 O ALA B 314 ? O ALA B 300 N SER B 233 ? N SER B 222 H 4 5 N ILE B 232 ? N ILE B 221 O HIS B 301 ? O HIS B 287 I 1 2 O LEU B 216 ? O LEU B 205 N VAL B 208 ? N VAL B 197 I 2 3 N GLY B 207 ? N GLY B 196 O HIS B 271 ? O HIS B 261 I 3 4 N ILE B 268 ? N ILE B 258 O LEU B 279 ? O LEU B 269 J 1 2 N LYS B 249 ? N LYS B 238 O VAL B 256 ? O VAL B 246 J 2 3 N VAL B 257 ? N VAL B 247 O CYS B 296 ? O CYS B 282 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE NAG A 1000' AC2 Software ? ? ? ? 20 'BINDING SITE FOR RESIDUE 3ZJ A 1001' AC3 Software ? ? ? ? 9 'BINDING SITE FOR RESIDUE SO4 A 1002' AC4 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE NAG B 1000' AC5 Software ? ? ? ? 21 'BINDING SITE FOR RESIDUE 3ZJ B 1001' AC6 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE DMS B 1002' AC7 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE DMS B 1003' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 1 ASN A 75 ? ASN A 67 . ? 1_555 ? 2 AC2 20 THR A 18 ? THR A 12 . ? 1_555 ? 3 AC2 20 GLN A 19 ? GLN A 13 . ? 1_555 ? 4 AC2 20 TYR A 20 ? TYR A 14 . ? 1_555 ? 5 AC2 20 VAL A 36 ? VAL A 30 . ? 1_555 ? 6 AC2 20 ASP A 38 ? ASP A 32 . ? 1_555 ? 7 AC2 20 GLY A 40 ? GLY A 34 . ? 1_555 ? 8 AC2 20 TYR A 83 ? TYR A 75 . ? 1_555 ? 9 AC2 20 SER A 84 ? SER A 76 . ? 1_555 ? 10 AC2 20 THR A 85 ? THR A 77 . ? 1_555 ? 11 AC2 20 PRO A 118 ? PRO A 111 . ? 1_555 ? 12 AC2 20 PHE A 124 ? PHE A 117 . ? 1_555 ? 13 AC2 20 VAL A 127 ? VAL A 120 . ? 1_555 ? 14 AC2 20 LEU A 224 ? LEU A 213 . ? 1_555 ? 15 AC2 20 ASP A 226 ? ASP A 215 . ? 1_555 ? 16 AC2 20 THR A 227 ? THR A 216 . ? 1_555 ? 17 AC2 20 GLY A 228 ? GLY A 217 . ? 1_555 ? 18 AC2 20 ALA A 229 ? ALA A 218 . ? 1_555 ? 19 AC2 20 SER A 230 ? SER A 219 . ? 1_555 ? 20 AC2 20 ILE A 305 ? ILE A 291 . ? 1_555 ? 21 AC2 20 HOH J . ? HOH A 1172 . ? 1_555 ? 22 AC3 9 ASP A 17 ? ASP A 11 . ? 1_555 ? 23 AC3 9 ALA A 282 ? ALA A 272 . ? 1_555 ? 24 AC3 9 ASP A 283 ? ASP A 273 . ? 1_555 ? 25 AC3 9 TYR A 284 ? TYR A 274 . ? 1_555 ? 26 AC3 9 VAL A 285 ? VAL A 275 . ? 1_555 ? 27 AC3 9 PHE A 286 ? PHE A 276 . ? 1_555 ? 28 AC3 9 ALA A 299 ? ALA A 285 . ? 1_555 ? 29 AC3 9 ARG A 321 ? ARG A 307 . ? 1_555 ? 30 AC3 9 HOH J . ? HOH A 1123 . ? 1_555 ? 31 AC4 1 ASN B 75 ? ASN B 67 . ? 1_555 ? 32 AC5 21 THR B 18 ? THR B 12 . ? 1_555 ? 33 AC5 21 GLN B 19 ? GLN B 13 . ? 1_555 ? 34 AC5 21 TYR B 20 ? TYR B 14 . ? 1_555 ? 35 AC5 21 ASP B 38 ? ASP B 32 . ? 1_555 ? 36 AC5 21 GLY B 40 ? GLY B 34 . ? 1_555 ? 37 AC5 21 TYR B 83 ? TYR B 75 . ? 1_555 ? 38 AC5 21 SER B 84 ? SER B 76 . ? 1_555 ? 39 AC5 21 THR B 85 ? THR B 77 . ? 1_555 ? 40 AC5 21 PRO B 118 ? PRO B 111 . ? 1_555 ? 41 AC5 21 LEU B 121 ? LEU B 114 . ? 1_555 ? 42 AC5 21 PHE B 124 ? PHE B 117 . ? 1_555 ? 43 AC5 21 VAL B 127 ? VAL B 120 . ? 1_555 ? 44 AC5 21 LEU B 224 ? LEU B 213 . ? 1_555 ? 45 AC5 21 ASP B 226 ? ASP B 215 . ? 1_555 ? 46 AC5 21 THR B 227 ? THR B 216 . ? 1_555 ? 47 AC5 21 GLY B 228 ? GLY B 217 . ? 1_555 ? 48 AC5 21 ALA B 229 ? ALA B 218 . ? 1_555 ? 49 AC5 21 SER B 230 ? SER B 219 . ? 1_555 ? 50 AC5 21 THR B 309 ? THR B 295 . ? 1_555 ? 51 AC5 21 DMS H . ? DMS B 1002 . ? 1_555 ? 52 AC5 21 DMS I . ? DMS B 1003 . ? 1_555 ? 53 AC6 3 SER B 230 ? SER B 219 . ? 1_555 ? 54 AC6 3 MET B 303 ? MET B 289 . ? 1_555 ? 55 AC6 3 3ZJ G . ? 3ZJ B 1001 . ? 1_555 ? 56 AC7 4 THR B 18 ? THR B 12 . ? 1_555 ? 57 AC7 4 GLN B 19 ? GLN B 13 . ? 1_555 ? 58 AC7 4 SER B 230 ? SER B 219 . ? 1_555 ? 59 AC7 4 3ZJ G . ? 3ZJ B 1001 . ? 1_555 ? # _database_PDB_matrix.entry_id 4RYG _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 4RYG _atom_sites.fract_transf_matrix[1][1] 0.007058 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.007058 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.007058 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . THR A 1 2 ? 45.011 136.447 0.505 1.00 100.98 ? -4 THR A N 1 ATOM 2 C CA . THR A 1 2 ? 46.308 137.052 0.184 1.00 101.11 ? -4 THR A CA 1 ATOM 3 C C . THR A 1 2 ? 47.347 135.966 -0.140 1.00 105.01 ? -4 THR A C 1 ATOM 4 O O . THR A 1 2 ? 47.431 134.961 0.573 1.00 106.54 ? -4 THR A O 1 ATOM 5 C CB . THR A 1 2 ? 46.782 137.980 1.333 1.00 111.51 ? -4 THR A CB 1 ATOM 6 O OG1 . THR A 1 2 ? 45.723 138.863 1.722 1.00 113.39 ? -4 THR A OG1 1 ATOM 7 C CG2 . THR A 1 2 ? 48.038 138.789 0.973 1.00 109.17 ? -4 THR A CG2 1 ATOM 8 N N . LEU A 1 3 ? 48.127 136.167 -1.220 1.00 98.52 ? -3 LEU A N 1 ATOM 9 C CA . LEU A 1 3 ? 49.182 135.232 -1.615 1.00 96.94 ? -3 LEU A CA 1 ATOM 10 C C . LEU A 1 3 ? 50.554 135.902 -1.487 1.00 98.42 ? -3 LEU A C 1 ATOM 11 O O . LEU A 1 3 ? 50.713 137.071 -1.864 1.00 98.72 ? -3 LEU A O 1 ATOM 12 C CB . LEU A 1 3 ? 48.965 134.671 -3.040 1.00 96.83 ? -3 LEU A CB 1 ATOM 13 C CG . LEU A 1 3 ? 47.816 133.648 -3.268 1.00 100.95 ? -3 LEU A CG 1 ATOM 14 C CD1 . LEU A 1 3 ? 47.692 133.293 -4.741 1.00 100.88 ? -3 LEU A CD1 1 ATOM 15 C CD2 . LEU A 1 3 ? 48.016 132.363 -2.476 1.00 102.38 ? -3 LEU A CD2 1 ATOM 16 N N . GLY A 1 4 ? 51.508 135.165 -0.922 1.00 91.64 ? -2 GLY A N 1 ATOM 17 C CA . GLY A 1 4 ? 52.873 135.630 -0.716 1.00 89.66 ? -2 GLY A CA 1 ATOM 18 C C . GLY A 1 4 ? 53.825 135.037 -1.727 1.00 89.58 ? -2 GLY A C 1 ATOM 19 O O . GLY A 1 4 ? 53.432 134.753 -2.867 1.00 88.16 ? -2 GLY A O 1 ATOM 20 N N . ASN A 1 5 ? 55.082 134.844 -1.310 1.00 84.53 ? -1 ASN A N 1 ATOM 21 C CA . ASN A 1 5 ? 56.136 134.276 -2.159 1.00 84.04 ? -1 ASN A CA 1 ATOM 22 C C . ASN A 1 5 ? 56.877 133.159 -1.396 1.00 84.63 ? -1 ASN A C 1 ATOM 23 O O . ASN A 1 5 ? 58.047 132.872 -1.678 1.00 84.81 ? -1 ASN A O 1 ATOM 24 C CB . ASN A 1 5 ? 57.102 135.398 -2.607 1.00 88.21 ? -1 ASN A CB 1 ATOM 25 C CG . ASN A 1 5 ? 57.868 135.097 -3.881 1.00 123.87 ? -1 ASN A CG 1 ATOM 26 O OD1 . ASN A 1 5 ? 57.295 134.993 -4.974 1.00 120.03 ? -1 ASN A OD1 1 ATOM 27 N ND2 . ASN A 1 5 ? 59.188 134.974 -3.774 1.00 117.84 ? -1 ASN A ND2 1 ATOM 28 N N . THR A 1 6 ? 56.182 132.517 -0.441 1.00 77.49 ? 0 THR A N 1 ATOM 29 C CA . THR A 1 6 ? 56.795 131.508 0.409 1.00 75.47 ? 0 THR A CA 1 ATOM 30 C C . THR A 1 6 ? 56.185 130.105 0.241 1.00 74.71 ? 0 THR A C 1 ATOM 31 O O . THR A 1 6 ? 54.985 129.939 0.017 1.00 74.38 ? 0 THR A O 1 ATOM 32 C CB . THR A 1 6 ? 56.781 132.022 1.880 1.00 81.81 ? 0 THR A CB 1 ATOM 33 O OG1 . THR A 1 6 ? 57.996 132.730 2.118 1.00 83.73 ? 0 THR A OG1 1 ATOM 34 C CG2 . THR A 1 6 ? 56.596 130.919 2.941 1.00 77.67 ? 0 THR A CG2 1 ATOM 35 N N . THR A 1 7 ? 57.067 129.106 0.338 1.00 67.18 ? 1 THR A N 1 ATOM 36 C CA . THR A 1 7 ? 56.757 127.686 0.390 1.00 65.47 ? 1 THR A CA 1 ATOM 37 C C . THR A 1 7 ? 57.529 127.155 1.572 1.00 64.23 ? 1 THR A C 1 ATOM 38 O O . THR A 1 7 ? 58.631 127.639 1.860 1.00 62.93 ? 1 THR A O 1 ATOM 39 C CB . THR A 1 7 ? 57.156 126.913 -0.882 1.00 73.42 ? 1 THR A CB 1 ATOM 40 O OG1 . THR A 1 7 ? 58.559 127.033 -1.117 1.00 77.10 ? 1 THR A OG1 1 ATOM 41 C CG2 . THR A 1 7 ? 56.366 127.327 -2.103 1.00 67.68 ? 1 THR A CG2 1 ATOM 42 N N . SER A 1 8 ? 56.952 126.228 2.289 1.00 58.41 ? 2 SER A N 1 ATOM 43 C CA . SER A 1 8 ? 57.688 125.632 3.387 1.00 57.86 ? 2 SER A CA 1 ATOM 44 C C . SER A 1 8 ? 57.535 124.139 3.323 1.00 57.42 ? 2 SER A C 1 ATOM 45 O O . SER A 1 8 ? 56.509 123.619 2.887 1.00 57.13 ? 2 SER A O 1 ATOM 46 C CB . SER A 1 8 ? 57.306 126.221 4.744 1.00 62.84 ? 2 SER A CB 1 ATOM 47 O OG . SER A 1 8 ? 56.057 125.744 5.209 1.00 79.39 ? 2 SER A OG 1 ATOM 48 N N . SER A 1 9 ? 58.564 123.448 3.701 1.00 50.79 ? 3 SER A N 1 ATOM 49 C CA . SER A 1 9 ? 58.523 122.010 3.651 1.00 49.43 ? 3 SER A CA 1 ATOM 50 C C . SER A 1 9 ? 58.705 121.357 5.024 1.00 51.10 ? 3 SER A C 1 ATOM 51 O O . SER A 1 9 ? 59.455 121.849 5.866 1.00 50.25 ? 3 SER A O 1 ATOM 52 C CB . SER A 1 9 ? 59.527 121.498 2.622 1.00 51.68 ? 3 SER A CB 1 ATOM 53 O OG . SER A 1 9 ? 60.838 121.412 3.148 1.00 59.02 ? 3 SER A OG 1 ATOM 54 N N . VAL A 1 10 ? 58.010 120.243 5.236 1.00 46.95 ? 4 VAL A N 1 ATOM 55 C CA . VAL A 1 10 ? 58.163 119.449 6.450 1.00 46.18 ? 4 VAL A CA 1 ATOM 56 C C . VAL A 1 10 ? 58.707 118.092 6.009 1.00 48.49 ? 4 VAL A C 1 ATOM 57 O O . VAL A 1 10 ? 58.079 117.430 5.182 1.00 47.97 ? 4 VAL A O 1 ATOM 58 C CB . VAL A 1 10 ? 56.863 119.303 7.299 1.00 49.63 ? 4 VAL A CB 1 ATOM 59 C CG1 . VAL A 1 10 ? 57.073 118.358 8.491 1.00 49.59 ? 4 VAL A CG1 1 ATOM 60 C CG2 . VAL A 1 10 ? 56.350 120.660 7.761 1.00 49.59 ? 4 VAL A CG2 1 ATOM 61 N N . ILE A 1 11 ? 59.884 117.707 6.533 1.00 43.19 ? 5 ILE A N 1 ATOM 62 C CA . ILE A 1 11 ? 60.481 116.416 6.257 1.00 43.03 ? 5 ILE A CA 1 ATOM 63 C C . ILE A 1 11 ? 59.715 115.376 7.109 1.00 41.89 ? 5 ILE A C 1 ATOM 64 O O . ILE A 1 11 ? 59.411 115.641 8.286 1.00 40.10 ? 5 ILE A O 1 ATOM 65 C CB . ILE A 1 11 ? 62.025 116.421 6.551 1.00 47.39 ? 5 ILE A CB 1 ATOM 66 C CG1 . ILE A 1 11 ? 62.818 117.347 5.588 1.00 48.52 ? 5 ILE A CG1 1 ATOM 67 C CG2 . ILE A 1 11 ? 62.610 115.002 6.539 1.00 48.60 ? 5 ILE A CG2 1 ATOM 68 C CD1 . ILE A 1 11 ? 62.382 117.361 4.000 1.00 62.47 ? 5 ILE A CD1 1 ATOM 69 N N . LEU A 1 12 ? 59.399 114.216 6.500 1.00 34.83 ? 6 LEU A N 1 ATOM 70 C CA . LEU A 1 12 ? 58.681 113.163 7.186 1.00 35.01 ? 6 LEU A CA 1 ATOM 71 C C . LEU A 1 12 ? 59.534 111.918 7.426 1.00 38.19 ? 6 LEU A C 1 ATOM 72 O O . LEU A 1 12 ? 60.479 111.620 6.689 1.00 37.22 ? 6 LEU A O 1 ATOM 73 C CB . LEU A 1 12 ? 57.391 112.759 6.422 1.00 35.23 ? 6 LEU A CB 1 ATOM 74 C CG . LEU A 1 12 ? 56.422 113.839 5.958 1.00 37.86 ? 6 LEU A CG 1 ATOM 75 C CD1 . LEU A 1 12 ? 55.250 113.215 5.318 1.00 37.64 ? 6 LEU A CD1 1 ATOM 76 C CD2 . LEU A 1 12 ? 55.985 114.727 7.098 1.00 37.58 ? 6 LEU A CD2 1 ATOM 77 N N . THR A 1 13 ? 59.144 111.172 8.439 1.00 34.43 ? 7 THR A N 1 ATOM 78 C CA . THR A 1 13 ? 59.762 109.921 8.806 1.00 34.74 ? 7 THR A CA 1 ATOM 79 C C . THR A 1 13 ? 58.830 108.819 8.339 1.00 39.44 ? 7 THR A C 1 ATOM 80 O O . THR A 1 13 ? 57.625 108.882 8.573 1.00 40.18 ? 7 THR A O 1 ATOM 81 C CB . THR A 1 13 ? 60.006 109.899 10.327 1.00 41.44 ? 7 THR A CB 1 ATOM 82 O OG1 . THR A 1 13 ? 60.861 110.985 10.695 1.00 38.87 ? 7 THR A OG1 1 ATOM 83 C CG2 . THR A 1 13 ? 60.575 108.588 10.811 1.00 34.49 ? 7 THR A CG2 1 ATOM 84 N N . ASN A 1 14 ? 59.385 107.840 7.645 1.00 36.05 ? 8 ASN A N 1 ATOM 85 C CA . ASN A 1 14 ? 58.635 106.684 7.192 1.00 35.74 ? 8 ASN A CA 1 ATOM 86 C C . ASN A 1 14 ? 58.882 105.551 8.186 1.00 41.47 ? 8 ASN A C 1 ATOM 87 O O . ASN A 1 14 ? 59.983 104.966 8.217 1.00 41.35 ? 8 ASN A O 1 ATOM 88 C CB . ASN A 1 14 ? 59.071 106.264 5.773 1.00 31.36 ? 8 ASN A CB 1 ATOM 89 C CG . ASN A 1 14 ? 58.438 104.989 5.251 1.00 43.77 ? 8 ASN A CG 1 ATOM 90 O OD1 . ASN A 1 14 ? 57.745 104.245 5.953 1.00 38.75 ? 8 ASN A OD1 1 ATOM 91 N ND2 . ASN A 1 14 ? 58.629 104.725 3.980 1.00 38.32 ? 8 ASN A ND2 1 ATOM 92 N N . TYR A 1 15 ? 57.854 105.220 8.971 1.00 38.70 ? 9 TYR A N 1 ATOM 93 C CA . TYR A 1 15 ? 57.927 104.079 9.874 1.00 39.50 ? 9 TYR A CA 1 ATOM 94 C C . TYR A 1 15 ? 57.234 102.855 9.240 1.00 45.90 ? 9 TYR A C 1 ATOM 95 O O . TYR A 1 15 ? 56.000 102.844 9.126 1.00 46.20 ? 9 TYR A O 1 ATOM 96 C CB . TYR A 1 15 ? 57.333 104.393 11.258 1.00 40.01 ? 9 TYR A CB 1 ATOM 97 C CG . TYR A 1 15 ? 57.258 103.174 12.158 1.00 42.91 ? 9 TYR A CG 1 ATOM 98 C CD1 . TYR A 1 15 ? 58.415 102.604 12.697 1.00 44.92 ? 9 TYR A CD1 1 ATOM 99 C CD2 . TYR A 1 15 ? 56.035 102.585 12.468 1.00 43.88 ? 9 TYR A CD2 1 ATOM 100 C CE1 . TYR A 1 15 ? 58.352 101.479 13.518 1.00 47.38 ? 9 TYR A CE1 1 ATOM 101 C CE2 . TYR A 1 15 ? 55.959 101.472 13.306 1.00 45.08 ? 9 TYR A CE2 1 ATOM 102 C CZ . TYR A 1 15 ? 57.119 100.907 13.812 1.00 55.38 ? 9 TYR A CZ 1 ATOM 103 O OH . TYR A 1 15 ? 57.029 99.792 14.623 1.00 54.56 ? 9 TYR A OH 1 ATOM 104 N N . MET A 1 16 ? 58.039 101.846 8.824 1.00 42.70 ? 10 MET A N 1 ATOM 105 C CA . MET A 1 16 ? 57.612 100.541 8.274 1.00 44.25 ? 10 MET A CA 1 ATOM 106 C C . MET A 1 16 ? 56.650 100.597 7.091 1.00 44.93 ? 10 MET A C 1 ATOM 107 O O . MET A 1 16 ? 55.900 99.651 6.908 1.00 42.68 ? 10 MET A O 1 ATOM 108 C CB . MET A 1 16 ? 56.905 99.713 9.349 1.00 48.79 ? 10 MET A CB 1 ATOM 109 C CG . MET A 1 16 ? 57.722 99.347 10.551 1.00 56.58 ? 10 MET A CG 1 ATOM 110 S SD . MET A 1 16 ? 56.957 97.902 11.392 1.00 64.08 ? 10 MET A SD 1 ATOM 111 C CE . MET A 1 16 ? 55.175 98.371 11.428 1.00 59.03 ? 10 MET A CE 1 ATOM 112 N N . ASP A 1 17 ? 56.614 101.700 6.338 1.00 42.00 ? 11 ASP A N 1 ATOM 113 C CA . ASP A 1 17 ? 55.661 101.916 5.241 1.00 41.61 ? 11 ASP A CA 1 ATOM 114 C C . ASP A 1 17 ? 54.209 102.047 5.723 1.00 42.59 ? 11 ASP A C 1 ATOM 115 O O . ASP A 1 17 ? 53.318 102.157 4.883 1.00 43.15 ? 11 ASP A O 1 ATOM 116 C CB . ASP A 1 17 ? 55.784 100.861 4.117 1.00 43.89 ? 11 ASP A CB 1 ATOM 117 C CG . ASP A 1 17 ? 56.796 101.199 3.042 1.00 50.73 ? 11 ASP A CG 1 ATOM 118 O OD1 . ASP A 1 17 ? 57.480 102.258 3.169 1.00 50.01 ? 11 ASP A OD1 1 ATOM 119 O OD2 . ASP A 1 17 ? 56.884 100.437 2.060 1.00 51.73 ? 11 ASP A OD2 1 ATOM 120 N N . THR A 1 18 ? 53.967 102.084 7.053 1.00 35.89 ? 12 THR A N 1 ATOM 121 C CA . THR A 1 18 ? 52.618 102.221 7.605 1.00 34.70 ? 12 THR A CA 1 ATOM 122 C C . THR A 1 18 ? 52.351 103.569 8.256 1.00 40.00 ? 12 THR A C 1 ATOM 123 O O . THR A 1 18 ? 51.210 104.006 8.258 1.00 41.89 ? 12 THR A O 1 ATOM 124 C CB . THR A 1 18 ? 52.283 101.111 8.585 1.00 39.46 ? 12 THR A CB 1 ATOM 125 O OG1 . THR A 1 18 ? 53.223 101.094 9.666 1.00 45.10 ? 12 THR A OG1 1 ATOM 126 C CG2 . THR A 1 18 ? 52.180 99.776 7.951 1.00 34.31 ? 12 THR A CG2 1 ATOM 127 N N . GLN A 1 19 ? 53.360 104.220 8.842 1.00 35.52 ? 13 GLN A N 1 ATOM 128 C CA . GLN A 1 19 ? 53.156 105.507 9.515 1.00 33.68 ? 13 GLN A CA 1 ATOM 129 C C . GLN A 1 19 ? 54.138 106.519 8.979 1.00 37.55 ? 13 GLN A C 1 ATOM 130 O O . GLN A 1 19 ? 55.331 106.219 8.953 1.00 36.79 ? 13 GLN A O 1 ATOM 131 C CB . GLN A 1 19 ? 53.339 105.362 11.036 1.00 34.16 ? 13 GLN A CB 1 ATOM 132 C CG . GLN A 1 19 ? 52.406 104.324 11.681 1.00 32.49 ? 13 GLN A CG 1 ATOM 133 C CD . GLN A 1 19 ? 52.633 104.129 13.147 1.00 46.25 ? 13 GLN A CD 1 ATOM 134 O OE1 . GLN A 1 19 ? 52.950 105.075 13.859 1.00 43.76 ? 13 GLN A OE1 1 ATOM 135 N NE2 . GLN A 1 19 ? 52.448 102.901 13.642 1.00 32.91 ? 13 GLN A NE2 1 ATOM 136 N N . TYR A 1 20 ? 53.648 107.720 8.547 1.00 33.37 ? 14 TYR A N 1 ATOM 137 C CA . TYR A 1 20 ? 54.472 108.835 8.044 1.00 31.71 ? 14 TYR A CA 1 ATOM 138 C C . TYR A 1 20 ? 54.204 110.032 8.905 1.00 40.65 ? 14 TYR A C 1 ATOM 139 O O . TYR A 1 20 ? 53.050 110.466 9.053 1.00 42.96 ? 14 TYR A O 1 ATOM 140 C CB . TYR A 1 20 ? 54.136 109.158 6.589 1.00 31.78 ? 14 TYR A CB 1 ATOM 141 C CG . TYR A 1 20 ? 54.548 108.080 5.618 1.00 30.63 ? 14 TYR A CG 1 ATOM 142 C CD1 . TYR A 1 20 ? 53.785 106.926 5.466 1.00 30.40 ? 14 TYR A CD1 1 ATOM 143 C CD2 . TYR A 1 20 ? 55.704 108.210 4.851 1.00 32.20 ? 14 TYR A CD2 1 ATOM 144 C CE1 . TYR A 1 20 ? 54.157 105.926 4.580 1.00 29.14 ? 14 TYR A CE1 1 ATOM 145 C CE2 . TYR A 1 20 ? 56.086 107.215 3.952 1.00 33.78 ? 14 TYR A CE2 1 ATOM 146 C CZ . TYR A 1 20 ? 55.302 106.076 3.818 1.00 38.87 ? 14 TYR A CZ 1 ATOM 147 O OH . TYR A 1 20 ? 55.641 105.110 2.918 1.00 40.04 ? 14 TYR A OH 1 ATOM 148 N N . TYR A 1 21 ? 55.249 110.513 9.556 1.00 38.78 ? 15 TYR A N 1 ATOM 149 C CA . TYR A 1 21 ? 55.084 111.625 10.482 1.00 38.77 ? 15 TYR A CA 1 ATOM 150 C C . TYR A 1 21 ? 56.199 112.675 10.414 1.00 43.72 ? 15 TYR A C 1 ATOM 151 O O . TYR A 1 21 ? 57.348 112.361 10.097 1.00 42.94 ? 15 TYR A O 1 ATOM 152 C CB . TYR A 1 21 ? 54.901 111.088 11.923 1.00 39.28 ? 15 TYR A CB 1 ATOM 153 C CG . TYR A 1 21 ? 55.989 110.152 12.384 1.00 38.55 ? 15 TYR A CG 1 ATOM 154 C CD1 . TYR A 1 21 ? 57.117 110.632 13.043 1.00 39.89 ? 15 TYR A CD1 1 ATOM 155 C CD2 . TYR A 1 21 ? 55.875 108.778 12.203 1.00 39.00 ? 15 TYR A CD2 1 ATOM 156 C CE1 . TYR A 1 21 ? 58.128 109.766 13.475 1.00 39.67 ? 15 TYR A CE1 1 ATOM 157 C CE2 . TYR A 1 21 ? 56.893 107.907 12.599 1.00 40.03 ? 15 TYR A CE2 1 ATOM 158 C CZ . TYR A 1 21 ? 58.007 108.403 13.258 1.00 52.02 ? 15 TYR A CZ 1 ATOM 159 O OH . TYR A 1 21 ? 59.014 107.544 13.649 1.00 62.65 ? 15 TYR A OH 1 ATOM 160 N N . GLY A 1 22 ? 55.829 113.918 10.712 1.00 39.20 ? 16 GLY A N 1 ATOM 161 C CA . GLY A 1 22 ? 56.762 115.033 10.787 1.00 37.45 ? 16 GLY A CA 1 ATOM 162 C C . GLY A 1 22 ? 56.781 115.628 12.194 1.00 41.33 ? 16 GLY A C 1 ATOM 163 O O . GLY A 1 22 ? 56.099 115.158 13.120 1.00 38.75 ? 16 GLY A O 1 ATOM 164 N N . GLU A 1 23 ? 57.489 116.738 12.335 1.00 40.11 ? 17 GLU A N 1 ATOM 165 C CA . GLU A 1 23 ? 57.632 117.410 13.607 1.00 40.30 ? 17 GLU A CA 1 ATOM 166 C C . GLU A 1 23 ? 57.061 118.783 13.607 1.00 44.88 ? 17 GLU A C 1 ATOM 167 O O . GLU A 1 23 ? 57.187 119.538 12.628 1.00 45.04 ? 17 GLU A O 1 ATOM 168 C CB . GLU A 1 23 ? 59.105 117.473 14.024 1.00 42.20 ? 17 GLU A CB 1 ATOM 169 C CG . GLU A 1 23 ? 59.315 117.117 15.486 1.00 56.87 ? 17 GLU A CG 1 ATOM 170 C CD . GLU A 1 23 ? 60.399 116.094 15.738 1.00 86.73 ? 17 GLU A CD 1 ATOM 171 O OE1 . GLU A 1 23 ? 60.256 114.939 15.273 1.00 71.75 ? 17 GLU A OE1 1 ATOM 172 O OE2 . GLU A 1 23 ? 61.386 116.447 16.423 1.00 96.79 ? 17 GLU A OE2 1 ATOM 173 N N . ILE A 1 24 ? 56.425 119.116 14.744 1.00 40.68 ? 18 ILE A N 1 ATOM 174 C CA . ILE A 1 24 ? 55.853 120.444 15.023 1.00 37.85 ? 18 ILE A CA 1 ATOM 175 C C . ILE A 1 24 ? 56.279 120.850 16.444 1.00 40.92 ? 18 ILE A C 1 ATOM 176 O O . ILE A 1 24 ? 56.600 119.988 17.278 1.00 39.58 ? 18 ILE A O 1 ATOM 177 C CB . ILE A 1 24 ? 54.307 120.532 14.822 1.00 39.34 ? 18 ILE A CB 1 ATOM 178 C CG1 . ILE A 1 24 ? 53.536 119.647 15.828 1.00 39.40 ? 18 ILE A CG1 1 ATOM 179 C CG2 . ILE A 1 24 ? 53.904 120.248 13.372 1.00 37.93 ? 18 ILE A CG2 1 ATOM 180 C CD1 . ILE A 1 24 ? 52.088 120.062 16.136 1.00 46.11 ? 18 ILE A CD1 1 ATOM 181 N N . GLY A 1 25 ? 56.287 122.153 16.693 1.00 37.44 ? 19 GLY A N 1 ATOM 182 C CA . GLY A 1 25 ? 56.603 122.728 17.995 1.00 36.96 ? 19 GLY A CA 1 ATOM 183 C C . GLY A 1 25 ? 55.395 123.448 18.545 1.00 43.51 ? 19 GLY A C 1 ATOM 184 O O . GLY A 1 25 ? 54.703 124.135 17.797 1.00 45.33 ? 19 GLY A O 1 ATOM 185 N N . ILE A 1 26 ? 55.084 123.253 19.833 1.00 38.94 ? 20 ILE A N 1 ATOM 186 C CA . ILE A 1 26 ? 53.925 123.893 20.460 1.00 38.62 ? 20 ILE A CA 1 ATOM 187 C C . ILE A 1 26 ? 54.371 124.619 21.722 1.00 44.12 ? 20 ILE A C 1 ATOM 188 O O . ILE A 1 26 ? 54.975 124.010 22.610 1.00 43.68 ? 20 ILE A O 1 ATOM 189 C CB . ILE A 1 26 ? 52.708 122.926 20.738 1.00 40.97 ? 20 ILE A CB 1 ATOM 190 C CG1 . ILE A 1 26 ? 52.359 122.045 19.503 1.00 40.69 ? 20 ILE A CG1 1 ATOM 191 C CG2 . ILE A 1 26 ? 51.471 123.725 21.198 1.00 40.81 ? 20 ILE A CG2 1 ATOM 192 C CD1 . ILE A 1 26 ? 51.331 120.957 19.747 1.00 39.15 ? 20 ILE A CD1 1 ATOM 193 N N . GLY A 1 27 ? 54.061 125.911 21.780 1.00 41.58 ? 21 GLY A N 1 ATOM 194 C CA . GLY A 1 27 ? 54.363 126.762 22.924 1.00 41.08 ? 21 GLY A CA 1 ATOM 195 C C . GLY A 1 27 ? 55.671 127.515 22.891 1.00 45.11 ? 21 GLY A C 1 ATOM 196 O O . GLY A 1 27 ? 56.416 127.442 21.908 1.00 44.06 ? 21 GLY A O 1 ATOM 197 N N . THR A 1 28 ? 55.932 128.270 23.981 1.00 43.02 ? 22 THR A N 1 ATOM 198 C CA . THR A 1 28 ? 57.150 129.058 24.202 1.00 43.16 ? 22 THR A CA 1 ATOM 199 C C . THR A 1 28 ? 57.744 128.670 25.557 1.00 46.88 ? 22 THR A C 1 ATOM 200 O O . THR A 1 28 ? 57.134 128.991 26.587 1.00 49.11 ? 22 THR A O 1 ATOM 201 C CB . THR A 1 28 ? 56.889 130.556 24.074 1.00 45.17 ? 22 THR A CB 1 ATOM 202 O OG1 . THR A 1 28 ? 56.256 130.795 22.821 1.00 45.83 ? 22 THR A OG1 1 ATOM 203 C CG2 . THR A 1 28 ? 58.169 131.367 24.157 1.00 35.84 ? 22 THR A CG2 1 ATOM 204 N N . PRO A 1 29 ? 58.901 127.966 25.599 1.00 39.49 ? 23 PRO A N 1 ATOM 205 C CA . PRO A 1 29 ? 59.700 127.452 24.460 1.00 38.06 ? 23 PRO A CA 1 ATOM 206 C C . PRO A 1 29 ? 58.971 126.301 23.749 1.00 40.22 ? 23 PRO A C 1 ATOM 207 O O . PRO A 1 29 ? 58.078 125.705 24.357 1.00 37.25 ? 23 PRO A O 1 ATOM 208 C CB . PRO A 1 29 ? 61.002 126.985 25.136 1.00 39.02 ? 23 PRO A CB 1 ATOM 209 C CG . PRO A 1 29 ? 60.575 126.576 26.518 1.00 43.29 ? 23 PRO A CG 1 ATOM 210 C CD . PRO A 1 29 ? 59.482 127.553 26.897 1.00 39.18 ? 23 PRO A CD 1 ATOM 211 N N . PRO A 1 30 ? 59.291 125.983 22.468 1.00 37.69 ? 24 PRO A N 1 ATOM 212 C CA . PRO A 1 30 ? 58.565 124.903 21.789 1.00 36.83 ? 24 PRO A CA 1 ATOM 213 C C . PRO A 1 30 ? 58.774 123.521 22.408 1.00 42.51 ? 24 PRO A C 1 ATOM 214 O O . PRO A 1 30 ? 59.895 123.126 22.795 1.00 41.82 ? 24 PRO A O 1 ATOM 215 C CB . PRO A 1 30 ? 59.102 124.963 20.348 1.00 37.88 ? 24 PRO A CB 1 ATOM 216 C CG . PRO A 1 30 ? 59.764 126.293 20.235 1.00 41.95 ? 24 PRO A CG 1 ATOM 217 C CD . PRO A 1 30 ? 60.311 126.563 21.569 1.00 37.59 ? 24 PRO A CD 1 ATOM 218 N N . GLN A 1 31 ? 57.651 122.799 22.532 1.00 39.43 ? 25 GLN A N 1 ATOM 219 C CA . GLN A 1 31 ? 57.580 121.406 22.970 1.00 38.04 ? 25 GLN A CA 1 ATOM 220 C C . GLN A 1 31 ? 57.354 120.689 21.647 1.00 41.57 ? 25 GLN A C 1 ATOM 221 O O . GLN A 1 31 ? 56.496 121.107 20.883 1.00 42.38 ? 25 GLN A O 1 ATOM 222 C CB . GLN A 1 31 ? 56.417 121.192 23.956 1.00 38.82 ? 25 GLN A CB 1 ATOM 223 C CG . GLN A 1 31 ? 56.602 121.947 25.285 1.00 25.48 ? 25 GLN A CG 1 ATOM 224 C CD . GLN A 1 31 ? 55.397 121.915 26.194 1.00 44.49 ? 25 GLN A CD 1 ATOM 225 O OE1 . GLN A 1 31 ? 54.851 120.859 26.512 1.00 37.38 ? 25 GLN A OE1 1 ATOM 226 N NE2 . GLN A 1 31 ? 54.994 123.071 26.697 1.00 39.22 ? 25 GLN A NE2 1 ATOM 227 N N . THR A 1 32 ? 58.206 119.721 21.304 1.00 37.53 ? 26 THR A N 1 ATOM 228 C CA . THR A 1 32 ? 58.128 119.052 20.006 1.00 36.63 ? 26 THR A CA 1 ATOM 229 C C . THR A 1 32 ? 57.329 117.771 20.051 1.00 40.34 ? 26 THR A C 1 ATOM 230 O O . THR A 1 32 ? 57.440 116.974 20.982 1.00 41.05 ? 26 THR A O 1 ATOM 231 C CB . THR A 1 32 ? 59.517 118.849 19.398 1.00 39.50 ? 26 THR A CB 1 ATOM 232 O OG1 . THR A 1 32 ? 60.284 118.070 20.308 1.00 45.06 ? 26 THR A OG1 1 ATOM 233 C CG2 . THR A 1 32 ? 60.228 120.164 19.102 1.00 30.93 ? 26 THR A CG2 1 ATOM 234 N N . PHE A 1 33 ? 56.527 117.564 19.007 1.00 35.24 ? 27 PHE A N 1 ATOM 235 C CA . PHE A 1 33 ? 55.676 116.385 18.859 1.00 32.56 ? 27 PHE A CA 1 ATOM 236 C C . PHE A 1 33 ? 55.843 115.849 17.468 1.00 33.14 ? 27 PHE A C 1 ATOM 237 O O . PHE A 1 33 ? 56.036 116.632 16.538 1.00 31.03 ? 27 PHE A O 1 ATOM 238 C CB . PHE A 1 33 ? 54.179 116.761 19.104 1.00 33.59 ? 27 PHE A CB 1 ATOM 239 C CG . PHE A 1 33 ? 53.929 117.288 20.496 1.00 33.00 ? 27 PHE A CG 1 ATOM 240 C CD1 . PHE A 1 33 ? 53.659 116.421 21.546 1.00 34.60 ? 27 PHE A CD1 1 ATOM 241 C CD2 . PHE A 1 33 ? 54.053 118.643 20.778 1.00 34.34 ? 27 PHE A CD2 1 ATOM 242 C CE1 . PHE A 1 33 ? 53.507 116.900 22.851 1.00 34.68 ? 27 PHE A CE1 1 ATOM 243 C CE2 . PHE A 1 33 ? 53.922 119.118 22.094 1.00 36.25 ? 27 PHE A CE2 1 ATOM 244 C CZ . PHE A 1 33 ? 53.641 118.241 23.115 1.00 32.98 ? 27 PHE A CZ 1 ATOM 245 N N . LYS A 1 34 ? 55.785 114.513 17.335 1.00 30.61 ? 28 LYS A N 1 ATOM 246 C CA . LYS A 1 34 ? 55.773 113.774 16.077 1.00 30.74 ? 28 LYS A CA 1 ATOM 247 C C . LYS A 1 34 ? 54.275 113.687 15.724 1.00 35.34 ? 28 LYS A C 1 ATOM 248 O O . LYS A 1 34 ? 53.468 113.213 16.538 1.00 34.46 ? 28 LYS A O 1 ATOM 249 C CB . LYS A 1 34 ? 56.361 112.360 16.247 1.00 33.10 ? 28 LYS A CB 1 ATOM 250 C CG . LYS A 1 34 ? 57.801 112.299 16.716 1.00 33.61 ? 28 LYS A CG 1 ATOM 251 C CD . LYS A 1 34 ? 58.232 110.844 16.922 1.00 35.61 ? 28 LYS A CD 1 ATOM 252 C CE . LYS A 1 34 ? 59.208 110.575 18.025 1.00 51.70 ? 28 LYS A CE 1 ATOM 253 N NZ . LYS A 1 34 ? 58.493 110.072 19.244 1.00 67.27 ? 28 LYS A NZ 1 ATOM 254 N N . VAL A 1 35 ? 53.891 114.248 14.573 1.00 34.20 ? 29 VAL A N 1 ATOM 255 C CA . VAL A 1 35 ? 52.466 114.304 14.169 1.00 34.78 ? 29 VAL A CA 1 ATOM 256 C C . VAL A 1 35 ? 52.224 113.717 12.761 1.00 40.89 ? 29 VAL A C 1 ATOM 257 O O . VAL A 1 35 ? 53.113 113.757 11.882 1.00 39.68 ? 29 VAL A O 1 ATOM 258 C CB . VAL A 1 35 ? 51.838 115.743 14.305 1.00 37.23 ? 29 VAL A CB 1 ATOM 259 C CG1 . VAL A 1 35 ? 51.844 116.226 15.761 1.00 37.26 ? 29 VAL A CG1 1 ATOM 260 C CG2 . VAL A 1 35 ? 52.523 116.767 13.400 1.00 36.07 ? 29 VAL A CG2 1 ATOM 261 N N . VAL A 1 36 ? 51.001 113.208 12.559 1.00 37.69 ? 30 VAL A N 1 ATOM 262 C CA . VAL A 1 36 ? 50.546 112.718 11.272 1.00 37.39 ? 30 VAL A CA 1 ATOM 263 C C . VAL A 1 36 ? 49.802 113.900 10.610 1.00 38.82 ? 30 VAL A C 1 ATOM 264 O O . VAL A 1 36 ? 48.949 114.540 11.252 1.00 35.76 ? 30 VAL A O 1 ATOM 265 C CB . VAL A 1 36 ? 49.637 111.477 11.441 1.00 42.31 ? 30 VAL A CB 1 ATOM 266 C CG1 . VAL A 1 36 ? 48.844 111.198 10.166 1.00 42.75 ? 30 VAL A CG1 1 ATOM 267 C CG2 . VAL A 1 36 ? 50.460 110.257 11.835 1.00 42.10 ? 30 VAL A CG2 1 ATOM 268 N N . PHE A 1 37 ? 50.163 114.219 9.345 1.00 35.60 ? 31 PHE A N 1 ATOM 269 C CA . PHE A 1 37 ? 49.482 115.275 8.586 1.00 33.81 ? 31 PHE A CA 1 ATOM 270 C C . PHE A 1 37 ? 48.421 114.541 7.815 1.00 38.70 ? 31 PHE A C 1 ATOM 271 O O . PHE A 1 37 ? 48.734 113.776 6.901 1.00 40.13 ? 31 PHE A O 1 ATOM 272 C CB . PHE A 1 37 ? 50.462 116.052 7.707 1.00 33.94 ? 31 PHE A CB 1 ATOM 273 C CG . PHE A 1 37 ? 51.498 116.772 8.529 1.00 33.85 ? 31 PHE A CG 1 ATOM 274 C CD1 . PHE A 1 37 ? 51.254 118.048 9.019 1.00 35.76 ? 31 PHE A CD1 1 ATOM 275 C CD2 . PHE A 1 37 ? 52.708 116.152 8.862 1.00 33.74 ? 31 PHE A CD2 1 ATOM 276 C CE1 . PHE A 1 37 ? 52.207 118.698 9.835 1.00 36.15 ? 31 PHE A CE1 1 ATOM 277 C CE2 . PHE A 1 37 ? 53.673 116.823 9.635 1.00 35.41 ? 31 PHE A CE2 1 ATOM 278 C CZ . PHE A 1 37 ? 53.421 118.097 10.102 1.00 32.89 ? 31 PHE A CZ 1 ATOM 279 N N . ASP A 1 38 ? 47.184 114.638 8.311 1.00 35.73 ? 32 ASP A N 1 ATOM 280 C CA . ASP A 1 38 ? 46.019 113.840 7.895 1.00 36.65 ? 32 ASP A CA 1 ATOM 281 C C . ASP A 1 38 ? 44.943 114.623 7.137 1.00 40.09 ? 32 ASP A C 1 ATOM 282 O O . ASP A 1 38 ? 44.277 115.452 7.735 1.00 40.18 ? 32 ASP A O 1 ATOM 283 C CB . ASP A 1 38 ? 45.431 113.145 9.147 1.00 38.76 ? 32 ASP A CB 1 ATOM 284 C CG . ASP A 1 38 ? 44.162 112.365 8.939 1.00 49.81 ? 32 ASP A CG 1 ATOM 285 O OD1 . ASP A 1 38 ? 43.902 111.958 7.792 1.00 50.72 ? 32 ASP A OD1 1 ATOM 286 O OD2 . ASP A 1 38 ? 43.446 112.122 9.938 1.00 53.41 ? 32 ASP A OD2 1 ATOM 287 N N . THR A 1 39 ? 44.763 114.327 5.839 1.00 36.13 ? 33 THR A N 1 ATOM 288 C CA . THR A 1 39 ? 43.767 114.989 4.980 1.00 36.48 ? 33 THR A CA 1 ATOM 289 C C . THR A 1 39 ? 42.335 114.452 5.220 1.00 41.66 ? 33 THR A C 1 ATOM 290 O O . THR A 1 39 ? 41.363 115.053 4.769 1.00 42.26 ? 33 THR A O 1 ATOM 291 C CB . THR A 1 39 ? 44.161 114.956 3.496 1.00 39.02 ? 33 THR A CB 1 ATOM 292 O OG1 . THR A 1 39 ? 44.406 113.596 3.092 1.00 38.65 ? 33 THR A OG1 1 ATOM 293 C CG2 . THR A 1 39 ? 45.347 115.851 3.198 1.00 37.07 ? 33 THR A CG2 1 ATOM 294 N N . GLY A 1 40 ? 42.237 113.351 5.946 1.00 38.51 ? 34 GLY A N 1 ATOM 295 C CA . GLY A 1 40 ? 40.982 112.728 6.319 1.00 38.94 ? 34 GLY A CA 1 ATOM 296 C C . GLY A 1 40 ? 40.355 113.326 7.564 1.00 44.57 ? 34 GLY A C 1 ATOM 297 O O . GLY A 1 40 ? 39.266 112.900 7.936 1.00 45.61 ? 34 GLY A O 1 ATOM 298 N N . SER A 1 41 ? 41.022 114.305 8.224 1.00 39.96 ? 35 SER A N 1 ATOM 299 C CA . SER A 1 41 ? 40.528 114.956 9.453 1.00 39.81 ? 35 SER A CA 1 ATOM 300 C C . SER A 1 41 ? 40.946 116.444 9.507 1.00 45.13 ? 35 SER A C 1 ATOM 301 O O . SER A 1 41 ? 41.830 116.847 8.759 1.00 45.72 ? 35 SER A O 1 ATOM 302 C CB . SER A 1 41 ? 40.940 114.180 10.705 1.00 40.60 ? 35 SER A CB 1 ATOM 303 O OG . SER A 1 41 ? 42.327 114.304 10.985 1.00 45.81 ? 35 SER A OG 1 ATOM 304 N N . SER A 1 42 ? 40.293 117.260 10.342 1.00 40.94 ? 36 SER A N 1 ATOM 305 C CA . SER A 1 42 ? 40.541 118.704 10.341 1.00 41.93 ? 36 SER A CA 1 ATOM 306 C C . SER A 1 42 ? 40.966 119.308 11.674 1.00 45.51 ? 36 SER A C 1 ATOM 307 O O . SER A 1 42 ? 41.066 120.537 11.785 1.00 44.55 ? 36 SER A O 1 ATOM 308 C CB . SER A 1 42 ? 39.306 119.431 9.819 1.00 48.91 ? 36 SER A CB 1 ATOM 309 O OG . SER A 1 42 ? 38.819 118.828 8.627 1.00 63.64 ? 36 SER A OG 1 ATOM 310 N N . ASN A 1 43 ? 41.233 118.444 12.678 1.00 41.09 ? 37 ASN A N 1 ATOM 311 C CA . ASN A 1 43 ? 41.629 118.876 14.009 1.00 39.87 ? 37 ASN A CA 1 ATOM 312 C C . ASN A 1 43 ? 43.107 118.652 14.257 1.00 43.13 ? 37 ASN A C 1 ATOM 313 O O . ASN A 1 43 ? 43.712 117.738 13.694 1.00 43.78 ? 37 ASN A O 1 ATOM 314 C CB . ASN A 1 43 ? 40.813 118.137 15.072 1.00 37.54 ? 37 ASN A CB 1 ATOM 315 C CG . ASN A 1 43 ? 39.342 118.463 15.033 1.00 56.47 ? 37 ASN A CG 1 ATOM 316 O OD1 . ASN A 1 43 ? 38.565 117.812 14.326 1.00 52.93 ? 37 ASN A OD1 1 ATOM 317 N ND2 . ASN A 1 43 ? 38.921 119.451 15.810 1.00 38.66 ? 37 ASN A ND2 1 ATOM 318 N N . VAL A 1 44 ? 43.688 119.497 15.104 1.00 38.20 ? 38 VAL A N 1 ATOM 319 C CA . VAL A 1 44 ? 45.050 119.359 15.587 1.00 36.73 ? 38 VAL A CA 1 ATOM 320 C C . VAL A 1 44 ? 44.891 118.861 17.016 1.00 40.52 ? 38 VAL A C 1 ATOM 321 O O . VAL A 1 44 ? 44.079 119.395 17.778 1.00 40.34 ? 38 VAL A O 1 ATOM 322 C CB . VAL A 1 44 ? 45.881 120.670 15.533 1.00 39.39 ? 38 VAL A CB 1 ATOM 323 C CG1 . VAL A 1 44 ? 47.288 120.453 16.118 1.00 39.60 ? 38 VAL A CG1 1 ATOM 324 C CG2 . VAL A 1 44 ? 45.972 121.220 14.114 1.00 38.44 ? 38 VAL A CG2 1 ATOM 325 N N . TRP A 1 45 ? 45.619 117.813 17.369 1.00 37.21 ? 39 TRP A N 1 ATOM 326 C CA . TRP A 1 45 ? 45.616 117.300 18.739 1.00 35.79 ? 39 TRP A CA 1 ATOM 327 C C . TRP A 1 45 ? 46.932 116.633 19.079 1.00 39.56 ? 39 TRP A C 1 ATOM 328 O O . TRP A 1 45 ? 47.549 116.006 18.214 1.00 38.46 ? 39 TRP A O 1 ATOM 329 C CB . TRP A 1 45 ? 44.420 116.378 19.006 1.00 34.03 ? 39 TRP A CB 1 ATOM 330 C CG . TRP A 1 45 ? 44.477 115.016 18.367 1.00 34.51 ? 39 TRP A CG 1 ATOM 331 C CD1 . TRP A 1 45 ? 43.781 114.597 17.274 1.00 37.20 ? 39 TRP A CD1 1 ATOM 332 C CD2 . TRP A 1 45 ? 45.161 113.857 18.878 1.00 34.04 ? 39 TRP A CD2 1 ATOM 333 N NE1 . TRP A 1 45 ? 44.007 113.259 17.058 1.00 36.48 ? 39 TRP A NE1 1 ATOM 334 C CE2 . TRP A 1 45 ? 44.871 112.787 18.012 1.00 36.94 ? 39 TRP A CE2 1 ATOM 335 C CE3 . TRP A 1 45 ? 45.994 113.623 19.988 1.00 35.00 ? 39 TRP A CE3 1 ATOM 336 C CZ2 . TRP A 1 45 ? 45.408 111.516 18.195 1.00 35.89 ? 39 TRP A CZ2 1 ATOM 337 C CZ3 . TRP A 1 45 ? 46.523 112.363 20.171 1.00 36.39 ? 39 TRP A CZ3 1 ATOM 338 C CH2 . TRP A 1 45 ? 46.225 111.323 19.286 1.00 36.95 ? 39 TRP A CH2 1 ATOM 339 N N . VAL A 1 46 ? 47.346 116.736 20.346 1.00 37.47 ? 40 VAL A N 1 ATOM 340 C CA . VAL A 1 46 ? 48.562 116.086 20.886 1.00 36.20 ? 40 VAL A CA 1 ATOM 341 C C . VAL A 1 46 ? 48.232 115.475 22.256 1.00 37.03 ? 40 VAL A C 1 ATOM 342 O O . VAL A 1 46 ? 47.297 115.944 22.901 1.00 34.92 ? 40 VAL A O 1 ATOM 343 C CB . VAL A 1 46 ? 49.801 117.051 20.952 1.00 38.74 ? 40 VAL A CB 1 ATOM 344 C CG1 . VAL A 1 46 ? 50.316 117.398 19.556 1.00 37.16 ? 40 VAL A CG1 1 ATOM 345 C CG2 . VAL A 1 46 ? 49.512 118.318 21.775 1.00 38.22 ? 40 VAL A CG2 1 ATOM 346 N N . PRO A 1 47 ? 48.961 114.468 22.773 1.00 36.58 ? 41 PRO A N 1 ATOM 347 C CA . PRO A 1 47 ? 48.633 113.989 24.140 1.00 36.78 ? 41 PRO A CA 1 ATOM 348 C C . PRO A 1 47 ? 48.929 115.082 25.186 1.00 42.45 ? 41 PRO A C 1 ATOM 349 O O . PRO A 1 47 ? 49.838 115.900 24.988 1.00 42.70 ? 41 PRO A O 1 ATOM 350 C CB . PRO A 1 47 ? 49.500 112.727 24.315 1.00 37.34 ? 41 PRO A CB 1 ATOM 351 C CG . PRO A 1 47 ? 50.080 112.417 22.943 1.00 41.22 ? 41 PRO A CG 1 ATOM 352 C CD . PRO A 1 47 ? 50.106 113.723 22.200 1.00 37.61 ? 41 PRO A CD 1 ATOM 353 N N . SER A 1 48 ? 48.104 115.155 26.243 1.00 39.13 ? 42 SER A N 1 ATOM 354 C CA . SER A 1 48 ? 48.223 116.170 27.298 1.00 38.80 ? 42 SER A CA 1 ATOM 355 C C . SER A 1 48 ? 48.947 115.680 28.525 1.00 44.63 ? 42 SER A C 1 ATOM 356 O O . SER A 1 48 ? 48.949 114.482 28.819 1.00 44.02 ? 42 SER A O 1 ATOM 357 C CB . SER A 1 48 ? 46.843 116.689 27.706 1.00 40.48 ? 42 SER A CB 1 ATOM 358 O OG . SER A 1 48 ? 46.901 117.743 28.654 1.00 43.98 ? 42 SER A OG 1 ATOM 359 N N . SER A 1 49 ? 49.533 116.631 29.279 1.00 43.37 ? 43 SER A N 1 ATOM 360 C CA . SER A 1 49 ? 50.191 116.354 30.563 1.00 42.97 ? 43 SER A CA 1 ATOM 361 C C . SER A 1 49 ? 49.102 115.958 31.559 1.00 47.32 ? 43 SER A C 1 ATOM 362 O O . SER A 1 49 ? 49.362 115.216 32.496 1.00 47.01 ? 43 SER A O 1 ATOM 363 C CB . SER A 1 49 ? 50.923 117.589 31.072 1.00 43.22 ? 43 SER A CB 1 ATOM 364 O OG . SER A 1 49 ? 50.060 118.713 31.077 1.00 50.19 ? 43 SER A OG 1 ATOM 365 N N . LYS A 1 50 ? 47.875 116.434 31.321 1.00 44.11 ? 44 LYS A N 1 ATOM 366 C CA . LYS A 1 50 ? 46.707 116.154 32.142 1.00 44.19 ? 44 LYS A CA 1 ATOM 367 C C . LYS A 1 50 ? 46.109 114.779 31.847 1.00 51.25 ? 44 LYS A C 1 ATOM 368 O O . LYS A 1 50 ? 45.022 114.477 32.337 1.00 51.58 ? 44 LYS A O 1 ATOM 369 C CB . LYS A 1 50 ? 45.675 117.294 32.005 1.00 45.46 ? 44 LYS A CB 1 ATOM 370 C CG . LYS A 1 50 ? 46.185 118.582 32.628 1.00 42.30 ? 44 LYS A CG 1 ATOM 371 C CD . LYS A 1 50 ? 45.550 119.826 32.049 1.00 58.23 ? 44 LYS A CD 1 ATOM 372 C CE . LYS A 1 50 ? 46.178 121.098 32.599 1.00 69.23 ? 44 LYS A CE 1 ATOM 373 N NZ . LYS A 1 50 ? 47.503 121.398 31.973 1.00 70.68 ? 44 LYS A NZ 1 ATOM 374 N N . CYS A 1 51 ? 46.813 113.928 31.069 1.00 50.02 ? 45 CYS A N 1 ATOM 375 C CA . CYS A 1 51 ? 46.375 112.564 30.745 1.00 50.08 ? 45 CYS A CA 1 ATOM 376 C C . CYS A 1 51 ? 46.871 111.603 31.825 1.00 55.94 ? 45 CYS A C 1 ATOM 377 O O . CYS A 1 51 ? 48.070 111.524 32.093 1.00 55.00 ? 45 CYS A O 1 ATOM 378 C CB . CYS A 1 51 ? 46.841 112.132 29.356 1.00 50.20 ? 45 CYS A CB 1 ATOM 379 S SG . CYS A 1 51 ? 46.482 110.399 28.961 1.00 54.07 ? 45 CYS A SG 1 ATOM 380 N N . SER A 1 52 ? 45.931 110.876 32.433 1.00 54.77 ? 46 SER A N 1 ATOM 381 C CA . SER A 1 52 ? 46.146 109.904 33.492 1.00 55.69 ? 46 SER A CA 1 ATOM 382 C C . SER A 1 52 ? 47.163 108.852 33.056 1.00 61.77 ? 46 SER A C 1 ATOM 383 O O . SER A 1 52 ? 46.973 108.225 32.012 1.00 61.52 ? 46 SER A O 1 ATOM 384 C CB . SER A 1 52 ? 44.815 109.251 33.864 1.00 60.97 ? 46 SER A CB 1 ATOM 385 O OG . SER A 1 52 ? 44.970 108.167 34.768 1.00 74.32 ? 46 SER A OG 1 ATOM 386 N N . ARG A 1 53 ? 48.232 108.648 33.864 1.00 59.38 ? 47 ARG A N 1 ATOM 387 C CA . ARG A 1 53 ? 49.291 107.666 33.596 1.00 59.86 ? 47 ARG A CA 1 ATOM 388 C C . ARG A 1 53 ? 48.810 106.208 33.640 1.00 63.44 ? 47 ARG A C 1 ATOM 389 O O . ARG A 1 53 ? 49.608 105.284 33.441 1.00 63.03 ? 47 ARG A O 1 ATOM 390 C CB . ARG A 1 53 ? 50.501 107.880 34.518 1.00 64.40 ? 47 ARG A CB 1 ATOM 391 C CG . ARG A 1 53 ? 51.246 109.216 34.347 1.00 74.05 ? 47 ARG A CG 1 ATOM 392 C CD . ARG A 1 53 ? 51.499 109.641 32.898 1.00 67.76 ? 47 ARG A CD 1 ATOM 393 N NE . ARG A 1 53 ? 51.072 111.027 32.712 1.00 67.42 ? 47 ARG A NE 1 ATOM 394 C CZ . ARG A 1 53 ? 51.840 112.094 32.922 1.00 74.26 ? 47 ARG A CZ 1 ATOM 395 N NH1 . ARG A 1 53 ? 53.112 111.950 33.284 1.00 67.28 ? 47 ARG A NH1 1 ATOM 396 N NH2 . ARG A 1 53 ? 51.352 113.304 32.756 1.00 56.41 ? 47 ARG A NH2 1 ATOM 397 N N . LEU A 1 54 A 47.484 106.015 33.860 1.00 59.69 ? 47 LEU A N 1 ATOM 398 C CA . LEU A 1 54 A 46.786 104.733 33.824 1.00 57.81 ? 47 LEU A CA 1 ATOM 399 C C . LEU A 1 54 A 46.549 104.347 32.356 1.00 60.74 ? 47 LEU A C 1 ATOM 400 O O . LEU A 1 54 A 46.479 103.148 32.075 1.00 61.18 ? 47 LEU A O 1 ATOM 401 C CB . LEU A 1 54 A 45.491 104.790 34.628 1.00 57.64 ? 47 LEU A CB 1 ATOM 402 C CG . LEU A 1 54 A 45.649 104.684 36.157 1.00 61.14 ? 47 LEU A CG 1 ATOM 403 C CD1 . LEU A 1 54 A 44.509 105.346 36.844 1.00 60.92 ? 47 LEU A CD1 1 ATOM 404 C CD2 . LEU A 1 54 A 45.787 103.238 36.629 1.00 61.15 ? 47 LEU A CD2 1 ATOM 405 N N . TYR A 1 55 B 46.498 105.365 31.412 1.00 55.11 ? 47 TYR A N 1 ATOM 406 C CA . TYR A 1 55 B 46.499 105.184 29.948 1.00 53.73 ? 47 TYR A CA 1 ATOM 407 C C . TYR A 1 55 B 47.973 104.957 29.609 1.00 56.04 ? 47 TYR A C 1 ATOM 408 O O . TYR A 1 55 B 48.783 105.899 29.719 1.00 55.29 ? 47 TYR A O 1 ATOM 409 C CB . TYR A 1 55 B 46.023 106.430 29.180 1.00 54.28 ? 47 TYR A CB 1 ATOM 410 C CG . TYR A 1 55 B 44.542 106.661 29.276 1.00 55.37 ? 47 TYR A CG 1 ATOM 411 C CD1 . TYR A 1 55 B 43.653 105.917 28.513 1.00 57.94 ? 47 TYR A CD1 1 ATOM 412 C CD2 . TYR A 1 55 B 44.019 107.598 30.165 1.00 55.74 ? 47 TYR A CD2 1 ATOM 413 C CE1 . TYR A 1 55 B 42.269 106.086 28.641 1.00 59.47 ? 47 TYR A CE1 1 ATOM 414 C CE2 . TYR A 1 55 B 42.641 107.774 30.306 1.00 56.65 ? 47 TYR A CE2 1 ATOM 415 C CZ . TYR A 1 55 B 41.768 107.020 29.536 1.00 64.57 ? 47 TYR A CZ 1 ATOM 416 O OH . TYR A 1 55 B 40.410 107.191 29.661 1.00 66.04 ? 47 TYR A OH 1 ATOM 417 N N . THR A 1 56 ? 48.335 103.703 29.244 1.00 50.84 ? 48 THR A N 1 ATOM 418 C CA . THR A 1 56 ? 49.729 103.354 28.940 1.00 50.03 ? 48 THR A CA 1 ATOM 419 C C . THR A 1 56 ? 50.257 104.151 27.735 1.00 52.65 ? 48 THR A C 1 ATOM 420 O O . THR A 1 56 ? 51.441 104.477 27.725 1.00 53.54 ? 48 THR A O 1 ATOM 421 C CB . THR A 1 56 ? 49.910 101.834 28.821 1.00 54.78 ? 48 THR A CB 1 ATOM 422 O OG1 . THR A 1 56 ? 49.213 101.194 29.904 1.00 50.45 ? 48 THR A OG1 1 ATOM 423 C CG2 . THR A 1 56 ? 51.392 101.413 28.796 1.00 47.50 ? 48 THR A CG2 1 ATOM 424 N N . ALA A 1 57 ? 49.362 104.534 26.782 1.00 47.33 ? 49 ALA A N 1 ATOM 425 C CA . ALA A 1 57 ? 49.663 105.326 25.587 1.00 46.19 ? 49 ALA A CA 1 ATOM 426 C C . ALA A 1 57 ? 50.298 106.647 25.978 1.00 51.03 ? 49 ALA A C 1 ATOM 427 O O . ALA A 1 57 ? 51.280 107.064 25.366 1.00 50.09 ? 49 ALA A O 1 ATOM 428 C CB . ALA A 1 57 ? 48.387 105.580 24.801 1.00 46.61 ? 49 ALA A CB 1 ATOM 429 N N . CYS A 1 58 ? 49.759 107.284 27.031 1.00 48.95 ? 50 CYS A N 1 ATOM 430 C CA . CYS A 1 58 ? 50.256 108.547 27.541 1.00 49.01 ? 50 CYS A CA 1 ATOM 431 C C . CYS A 1 58 ? 51.622 108.432 28.212 1.00 52.06 ? 50 CYS A C 1 ATOM 432 O O . CYS A 1 58 ? 52.408 109.384 28.187 1.00 51.64 ? 50 CYS A O 1 ATOM 433 C CB . CYS A 1 58 ? 49.220 109.200 28.442 1.00 49.70 ? 50 CYS A CB 1 ATOM 434 S SG . CYS A 1 58 ? 47.793 109.832 27.530 1.00 54.01 ? 50 CYS A SG 1 ATOM 435 N N . VAL A 1 59 ? 51.938 107.259 28.747 1.00 46.71 ? 51 VAL A N 1 ATOM 436 C CA . VAL A 1 59 ? 53.247 107.008 29.361 1.00 45.43 ? 51 VAL A CA 1 ATOM 437 C C . VAL A 1 59 ? 54.291 106.866 28.245 1.00 49.94 ? 51 VAL A C 1 ATOM 438 O O . VAL A 1 59 ? 55.467 107.167 28.462 1.00 51.07 ? 51 VAL A O 1 ATOM 439 C CB . VAL A 1 59 ? 53.214 105.731 30.268 1.00 48.43 ? 51 VAL A CB 1 ATOM 440 C CG1 . VAL A 1 59 ? 54.514 105.569 31.035 1.00 47.70 ? 51 VAL A CG1 1 ATOM 441 C CG2 . VAL A 1 59 ? 52.022 105.743 31.229 1.00 47.76 ? 51 VAL A CG2 1 ATOM 442 N N . TYR A 1 60 ? 53.861 106.416 27.051 1.00 45.54 ? 52 TYR A N 1 ATOM 443 C CA . TYR A 1 60 ? 54.760 106.173 25.920 1.00 44.85 ? 52 TYR A CA 1 ATOM 444 C C . TYR A 1 60 ? 54.826 107.290 24.850 1.00 44.07 ? 52 TYR A C 1 ATOM 445 O O . TYR A 1 60 ? 55.576 107.143 23.889 1.00 44.88 ? 52 TYR A O 1 ATOM 446 C CB . TYR A 1 60 ? 54.419 104.816 25.289 1.00 46.73 ? 52 TYR A CB 1 ATOM 447 C CG . TYR A 1 60 ? 54.977 103.683 26.119 1.00 49.86 ? 52 TYR A CG 1 ATOM 448 C CD1 . TYR A 1 60 ? 56.282 103.250 25.944 1.00 52.18 ? 52 TYR A CD1 1 ATOM 449 C CD2 . TYR A 1 60 ? 54.221 103.092 27.134 1.00 50.79 ? 52 TYR A CD2 1 ATOM 450 C CE1 . TYR A 1 60 ? 56.819 102.242 26.735 1.00 55.48 ? 52 TYR A CE1 1 ATOM 451 C CE2 . TYR A 1 60 ? 54.757 102.097 27.946 1.00 51.53 ? 52 TYR A CE2 1 ATOM 452 C CZ . TYR A 1 60 ? 56.058 101.673 27.737 1.00 64.70 ? 52 TYR A CZ 1 ATOM 453 O OH . TYR A 1 60 ? 56.626 100.667 28.476 1.00 75.25 ? 52 TYR A OH 1 ATOM 454 N N . HIS A 1 61 ? 54.115 108.403 25.031 1.00 37.72 ? 53 HIS A N 1 ATOM 455 C CA . HIS A 1 61 ? 54.157 109.518 24.073 1.00 37.83 ? 53 HIS A CA 1 ATOM 456 C C . HIS A 1 61 ? 54.519 110.837 24.739 1.00 43.57 ? 53 HIS A C 1 ATOM 457 O O . HIS A 1 61 ? 54.432 110.953 25.968 1.00 45.15 ? 53 HIS A O 1 ATOM 458 C CB . HIS A 1 61 ? 52.845 109.654 23.286 1.00 38.01 ? 53 HIS A CB 1 ATOM 459 C CG . HIS A 1 61 ? 52.645 108.533 22.324 1.00 40.95 ? 53 HIS A CG 1 ATOM 460 N ND1 . HIS A 1 61 ? 51.899 107.415 22.664 1.00 41.68 ? 53 HIS A ND1 1 ATOM 461 C CD2 . HIS A 1 61 ? 53.137 108.368 21.072 1.00 41.21 ? 53 HIS A CD2 1 ATOM 462 C CE1 . HIS A 1 61 ? 51.950 106.628 21.606 1.00 39.91 ? 53 HIS A CE1 1 ATOM 463 N NE2 . HIS A 1 61 ? 52.651 107.176 20.614 1.00 40.20 ? 53 HIS A NE2 1 ATOM 464 N N . LYS A 1 62 ? 54.961 111.816 23.930 1.00 38.55 ? 54 LYS A N 1 ATOM 465 C CA . LYS A 1 62 ? 55.294 113.157 24.407 1.00 38.13 ? 54 LYS A CA 1 ATOM 466 C C . LYS A 1 62 ? 53.985 113.854 24.789 1.00 42.79 ? 54 LYS A C 1 ATOM 467 O O . LYS A 1 62 ? 52.996 113.763 24.053 1.00 40.49 ? 54 LYS A O 1 ATOM 468 C CB . LYS A 1 62 ? 56.041 113.961 23.340 1.00 39.53 ? 54 LYS A CB 1 ATOM 469 C CG . LYS A 1 62 ? 56.727 115.201 23.906 1.00 60.61 ? 54 LYS A CG 1 ATOM 470 C CD . LYS A 1 62 ? 58.235 115.099 23.663 1.00 72.61 ? 54 LYS A CD 1 ATOM 471 C CE . LYS A 1 62 ? 59.011 116.277 24.161 1.00 72.68 ? 54 LYS A CE 1 ATOM 472 N NZ . LYS A 1 62 ? 58.665 117.517 23.429 1.00 80.76 ? 54 LYS A NZ 1 ATOM 473 N N . LEU A 1 63 ? 53.972 114.516 25.968 1.00 39.57 ? 55 LEU A N 1 ATOM 474 C CA . LEU A 1 63 ? 52.768 115.194 26.445 1.00 37.65 ? 55 LEU A CA 1 ATOM 475 C C . LEU A 1 63 ? 52.938 116.679 26.517 1.00 42.62 ? 55 LEU A C 1 ATOM 476 O O . LEU A 1 63 ? 53.991 117.159 26.938 1.00 44.72 ? 55 LEU A O 1 ATOM 477 C CB . LEU A 1 63 ? 52.342 114.647 27.797 1.00 36.68 ? 55 LEU A CB 1 ATOM 478 C CG . LEU A 1 63 ? 52.444 113.145 27.973 1.00 40.14 ? 55 LEU A CG 1 ATOM 479 C CD1 . LEU A 1 63 ? 52.229 112.772 29.414 1.00 41.56 ? 55 LEU A CD1 1 ATOM 480 C CD2 . LEU A 1 63 ? 51.444 112.411 27.118 1.00 37.98 ? 55 LEU A CD2 1 ATOM 481 N N . PHE A 1 64 ? 51.919 117.421 26.090 1.00 37.85 ? 56 PHE A N 1 ATOM 482 C CA . PHE A 1 64 ? 51.937 118.873 26.168 1.00 36.54 ? 56 PHE A CA 1 ATOM 483 C C . PHE A 1 64 ? 51.613 119.320 27.571 1.00 41.65 ? 56 PHE A C 1 ATOM 484 O O . PHE A 1 64 ? 50.568 118.959 28.133 1.00 40.07 ? 56 PHE A O 1 ATOM 485 C CB . PHE A 1 64 ? 50.975 119.507 25.164 1.00 37.38 ? 56 PHE A CB 1 ATOM 486 C CG . PHE A 1 64 ? 50.956 121.018 25.221 1.00 37.84 ? 56 PHE A CG 1 ATOM 487 C CD1 . PHE A 1 64 ? 52.014 121.764 24.715 1.00 40.56 ? 56 PHE A CD1 1 ATOM 488 C CD2 . PHE A 1 64 ? 49.884 121.695 25.786 1.00 39.87 ? 56 PHE A CD2 1 ATOM 489 C CE1 . PHE A 1 64 ? 52.005 123.163 24.777 1.00 40.62 ? 56 PHE A CE1 1 ATOM 490 C CE2 . PHE A 1 64 ? 49.873 123.094 25.843 1.00 42.43 ? 56 PHE A CE2 1 ATOM 491 C CZ . PHE A 1 64 ? 50.933 123.818 25.328 1.00 39.46 ? 56 PHE A CZ 1 ATOM 492 N N . ASP A 1 65 ? 52.517 120.133 28.125 1.00 40.35 ? 57 ASP A N 1 ATOM 493 C CA . ASP A 1 65 ? 52.380 120.735 29.440 1.00 40.49 ? 57 ASP A CA 1 ATOM 494 C C . ASP A 1 65 ? 52.268 122.251 29.249 1.00 44.26 ? 57 ASP A C 1 ATOM 495 O O . ASP A 1 65 ? 53.250 122.909 28.898 1.00 43.75 ? 57 ASP A O 1 ATOM 496 C CB . ASP A 1 65 ? 53.559 120.322 30.355 1.00 42.36 ? 57 ASP A CB 1 ATOM 497 C CG . ASP A 1 65 ? 53.310 120.517 31.847 1.00 53.77 ? 57 ASP A CG 1 ATOM 498 O OD1 . ASP A 1 65 ? 52.436 121.345 32.205 1.00 57.74 ? 57 ASP A OD1 1 ATOM 499 O OD2 . ASP A 1 65 ? 53.997 119.854 32.655 1.00 53.29 ? 57 ASP A OD2 1 ATOM 500 N N . ALA A 1 66 ? 51.044 122.781 29.415 1.00 41.40 ? 58 ALA A N 1 ATOM 501 C CA . ALA A 1 66 ? 50.690 124.196 29.275 1.00 40.87 ? 58 ALA A CA 1 ATOM 502 C C . ALA A 1 66 ? 51.368 125.086 30.332 1.00 47.85 ? 58 ALA A C 1 ATOM 503 O O . ALA A 1 66 ? 51.603 126.262 30.072 1.00 50.76 ? 58 ALA A O 1 ATOM 504 C CB . ALA A 1 66 ? 49.179 124.359 29.339 1.00 40.91 ? 58 ALA A CB 1 ATOM 505 N N . SER A 1 67 ? 51.681 124.523 31.514 1.00 44.29 ? 59 SER A N 1 ATOM 506 C CA . SER A 1 67 ? 52.378 125.179 32.635 1.00 43.49 ? 59 SER A CA 1 ATOM 507 C C . SER A 1 67 ? 53.832 125.571 32.245 1.00 45.24 ? 59 SER A C 1 ATOM 508 O O . SER A 1 67 ? 54.459 126.359 32.952 1.00 45.12 ? 59 SER A O 1 ATOM 509 C CB . SER A 1 67 ? 52.441 124.238 33.837 1.00 46.05 ? 59 SER A CB 1 ATOM 510 O OG . SER A 1 67 ? 51.167 123.993 34.408 1.00 64.02 ? 59 SER A OG 1 ATOM 511 N N . ASP A 1 68 ? 54.365 124.995 31.147 1.00 38.15 ? 60 ASP A N 1 ATOM 512 C CA . ASP A 1 68 ? 55.709 125.293 30.673 1.00 37.62 ? 60 ASP A CA 1 ATOM 513 C C . ASP A 1 68 ? 55.699 126.248 29.521 1.00 42.19 ? 60 ASP A C 1 ATOM 514 O O . ASP A 1 68 ? 56.762 126.653 29.046 1.00 41.22 ? 60 ASP A O 1 ATOM 515 C CB . ASP A 1 68 ? 56.480 124.006 30.342 1.00 38.81 ? 60 ASP A CB 1 ATOM 516 C CG . ASP A 1 68 ? 56.746 123.155 31.574 1.00 44.38 ? 60 ASP A CG 1 ATOM 517 O OD1 . ASP A 1 68 ? 56.981 123.743 32.672 1.00 47.91 ? 60 ASP A OD1 1 ATOM 518 O OD2 . ASP A 1 68 ? 56.705 121.913 31.453 1.00 44.01 ? 60 ASP A OD2 1 ATOM 519 N N . SER A 1 69 ? 54.493 126.653 29.074 1.00 40.06 ? 61 SER A N 1 ATOM 520 C CA . SER A 1 69 ? 54.391 127.561 27.935 1.00 39.02 ? 61 SER A CA 1 ATOM 521 C C . SER A 1 69 ? 53.898 128.942 28.341 1.00 43.73 ? 61 SER A C 1 ATOM 522 O O . SER A 1 69 ? 52.864 129.079 29.000 1.00 41.82 ? 61 SER A O 1 ATOM 523 C CB . SER A 1 69 ? 53.563 126.948 26.822 1.00 37.77 ? 61 SER A CB 1 ATOM 524 O OG . SER A 1 69 ? 53.385 127.908 25.801 1.00 47.51 ? 61 SER A OG 1 ATOM 525 N N . SER A 1 70 ? 54.667 129.965 27.951 1.00 42.96 ? 62 SER A N 1 ATOM 526 C CA . SER A 1 70 ? 54.350 131.366 28.262 1.00 42.84 ? 62 SER A CA 1 ATOM 527 C C . SER A 1 70 ? 53.375 131.971 27.240 1.00 46.61 ? 62 SER A C 1 ATOM 528 O O . SER A 1 70 ? 52.876 133.074 27.471 1.00 47.00 ? 62 SER A O 1 ATOM 529 C CB . SER A 1 70 ? 55.623 132.202 28.345 1.00 43.33 ? 62 SER A CB 1 ATOM 530 O OG . SER A 1 70 ? 56.260 132.243 27.080 1.00 51.66 ? 62 SER A OG 1 ATOM 531 N N . SER A 1 71 ? 53.113 131.247 26.116 1.00 40.98 ? 63 SER A N 1 ATOM 532 C CA . SER A 1 71 ? 52.225 131.701 25.041 1.00 39.66 ? 63 SER A CA 1 ATOM 533 C C . SER A 1 71 ? 50.850 130.987 25.055 1.00 43.94 ? 63 SER A C 1 ATOM 534 O O . SER A 1 71 ? 49.967 131.286 24.240 1.00 42.47 ? 63 SER A O 1 ATOM 535 C CB . SER A 1 71 ? 52.915 131.598 23.684 1.00 39.80 ? 63 SER A CB 1 ATOM 536 O OG . SER A 1 71 ? 53.626 130.383 23.521 1.00 42.04 ? 63 SER A OG 1 ATOM 537 N N . TYR A 1 72 ? 50.662 130.098 26.035 1.00 40.83 ? 64 TYR A N 1 ATOM 538 C CA . TYR A 1 72 ? 49.445 129.328 26.175 1.00 41.13 ? 64 TYR A CA 1 ATOM 539 C C . TYR A 1 72 ? 48.269 130.190 26.548 1.00 44.83 ? 64 TYR A C 1 ATOM 540 O O . TYR A 1 72 ? 48.392 131.062 27.406 1.00 46.34 ? 64 TYR A O 1 ATOM 541 C CB . TYR A 1 72 ? 49.656 128.175 27.180 1.00 42.23 ? 64 TYR A CB 1 ATOM 542 C CG . TYR A 1 72 ? 48.388 127.582 27.754 1.00 43.82 ? 64 TYR A CG 1 ATOM 543 C CD1 . TYR A 1 72 ? 47.623 126.671 27.022 1.00 45.39 ? 64 TYR A CD1 1 ATOM 544 C CD2 . TYR A 1 72 ? 47.976 127.893 29.045 1.00 44.42 ? 64 TYR A CD2 1 ATOM 545 C CE1 . TYR A 1 72 ? 46.475 126.091 27.566 1.00 45.73 ? 64 TYR A CE1 1 ATOM 546 C CE2 . TYR A 1 72 ? 46.816 127.345 29.587 1.00 45.33 ? 64 TYR A CE2 1 ATOM 547 C CZ . TYR A 1 72 ? 46.080 126.426 28.854 1.00 53.07 ? 64 TYR A CZ 1 ATOM 548 O OH . TYR A 1 72 ? 44.970 125.857 29.431 1.00 49.64 ? 64 TYR A OH 1 ATOM 549 N N . LYS A 1 73 ? 47.131 129.947 25.897 1.00 38.79 ? 65 LYS A N 1 ATOM 550 C CA . LYS A 1 73 ? 45.866 130.611 26.214 1.00 38.41 ? 65 LYS A CA 1 ATOM 551 C C . LYS A 1 73 ? 44.845 129.526 26.471 1.00 41.97 ? 65 LYS A C 1 ATOM 552 O O . LYS A 1 73 ? 44.631 128.659 25.620 1.00 43.85 ? 65 LYS A O 1 ATOM 553 C CB . LYS A 1 73 ? 45.357 131.584 25.115 1.00 39.08 ? 65 LYS A CB 1 ATOM 554 C CG . LYS A 1 73 ? 46.263 132.725 24.698 1.00 50.49 ? 65 LYS A CG 1 ATOM 555 C CD . LYS A 1 73 ? 46.548 133.897 25.669 1.00 60.53 ? 65 LYS A CD 1 ATOM 556 C CE . LYS A 1 73 ? 46.614 135.228 24.960 1.00 69.02 ? 65 LYS A CE 1 ATOM 557 N NZ . LYS A 1 73 ? 47.318 135.205 23.643 1.00 69.52 ? 65 LYS A NZ 1 ATOM 558 N N . HIS A 1 74 ? 44.228 129.577 27.637 1.00 36.33 ? 66 HIS A N 1 ATOM 559 C CA . HIS A 1 74 ? 43.216 128.642 28.097 1.00 37.37 ? 66 HIS A CA 1 ATOM 560 C C . HIS A 1 74 ? 41.934 128.664 27.250 1.00 43.78 ? 66 HIS A C 1 ATOM 561 O O . HIS A 1 74 ? 41.572 129.695 26.692 1.00 44.48 ? 66 HIS A O 1 ATOM 562 C CB . HIS A 1 74 ? 42.925 128.928 29.585 1.00 38.21 ? 66 HIS A CB 1 ATOM 563 C CG . HIS A 1 74 ? 41.716 128.249 30.139 1.00 42.05 ? 66 HIS A CG 1 ATOM 564 N ND1 . HIS A 1 74 ? 40.482 128.913 30.198 1.00 43.44 ? 66 HIS A ND1 1 ATOM 565 C CD2 . HIS A 1 74 ? 41.554 126.983 30.603 1.00 43.82 ? 66 HIS A CD2 1 ATOM 566 C CE1 . HIS A 1 74 ? 39.628 128.036 30.707 1.00 42.62 ? 66 HIS A CE1 1 ATOM 567 N NE2 . HIS A 1 74 ? 40.216 126.858 30.956 1.00 43.19 ? 66 HIS A NE2 1 ATOM 568 N N . ASN A 1 75 ? 41.265 127.516 27.153 1.00 40.43 ? 67 ASN A N 1 ATOM 569 C CA . ASN A 1 75 ? 39.957 127.407 26.532 1.00 41.34 ? 67 ASN A CA 1 ATOM 570 C C . ASN A 1 75 ? 39.164 126.412 27.340 1.00 45.82 ? 67 ASN A C 1 ATOM 571 O O . ASN A 1 75 ? 38.272 126.815 28.062 1.00 47.13 ? 67 ASN A O 1 ATOM 572 C CB . ASN A 1 75 ? 39.981 127.111 25.010 1.00 46.70 ? 67 ASN A CB 1 ATOM 573 C CG . ASN A 1 75 ? 38.594 127.212 24.447 1.00 77.54 ? 67 ASN A CG 1 ATOM 574 O OD1 . ASN A 1 75 ? 37.827 126.251 24.526 1.00 67.84 ? 67 ASN A OD1 1 ATOM 575 N ND2 . ASN A 1 75 ? 38.243 128.408 23.943 1.00 82.92 ? 67 ASN A ND2 1 ATOM 576 N N . GLY A 1 76 ? 39.537 125.143 27.281 1.00 41.95 ? 68 GLY A N 1 ATOM 577 C CA . GLY A 1 76 ? 38.915 124.116 28.092 1.00 42.22 ? 68 GLY A CA 1 ATOM 578 C C . GLY A 1 76 ? 37.645 123.478 27.590 1.00 49.23 ? 68 GLY A C 1 ATOM 579 O O . GLY A 1 76 ? 37.156 122.545 28.239 1.00 48.50 ? 68 GLY A O 1 ATOM 580 N N . THR A 1 77 ? 37.093 123.950 26.445 1.00 49.13 ? 69 THR A N 1 ATOM 581 C CA . THR A 1 77 ? 35.895 123.325 25.856 1.00 49.65 ? 69 THR A CA 1 ATOM 582 C C . THR A 1 77 ? 36.219 121.847 25.603 1.00 55.69 ? 69 THR A C 1 ATOM 583 O O . THR A 1 77 ? 37.288 121.546 25.051 1.00 54.57 ? 69 THR A O 1 ATOM 584 C CB . THR A 1 77 ? 35.500 124.004 24.532 1.00 57.00 ? 69 THR A CB 1 ATOM 585 O OG1 . THR A 1 77 ? 35.192 125.381 24.739 1.00 59.75 ? 69 THR A OG1 1 ATOM 586 C CG2 . THR A 1 77 ? 34.327 123.328 23.864 1.00 56.04 ? 69 THR A CG2 1 ATOM 587 N N . GLU A 1 78 ? 35.315 120.934 26.027 1.00 53.89 ? 70 GLU A N 1 ATOM 588 C CA . GLU A 1 78 ? 35.492 119.489 25.812 1.00 54.19 ? 70 GLU A CA 1 ATOM 589 C C . GLU A 1 78 ? 35.531 119.181 24.305 1.00 57.39 ? 70 GLU A C 1 ATOM 590 O O . GLU A 1 78 ? 34.966 119.919 23.494 1.00 57.83 ? 70 GLU A O 1 ATOM 591 C CB . GLU A 1 78 ? 34.398 118.697 26.526 1.00 56.17 ? 70 GLU A CB 1 ATOM 592 C CG . GLU A 1 78 ? 34.755 117.252 26.825 1.00 77.20 ? 70 GLU A CG 1 ATOM 593 C CD . GLU A 1 78 ? 33.687 116.486 27.589 1.00 116.38 ? 70 GLU A CD 1 ATOM 594 O OE1 . GLU A 1 78 ? 32.618 116.198 26.999 1.00 118.61 ? 70 GLU A OE1 1 ATOM 595 O OE2 . GLU A 1 78 ? 33.919 116.177 28.782 1.00 110.01 ? 70 GLU A OE2 1 ATOM 596 N N . LEU A 1 79 ? 36.260 118.137 23.933 1.00 53.44 ? 71 LEU A N 1 ATOM 597 C CA . LEU A 1 79 ? 36.465 117.717 22.553 1.00 52.49 ? 71 LEU A CA 1 ATOM 598 C C . LEU A 1 79 ? 36.554 116.188 22.510 1.00 53.39 ? 71 LEU A C 1 ATOM 599 O O . LEU A 1 79 ? 37.269 115.583 23.316 1.00 51.62 ? 71 LEU A O 1 ATOM 600 C CB . LEU A 1 79 ? 37.789 118.343 22.049 1.00 53.00 ? 71 LEU A CB 1 ATOM 601 C CG . LEU A 1 79 ? 38.149 118.152 20.584 1.00 59.15 ? 71 LEU A CG 1 ATOM 602 C CD1 . LEU A 1 79 ? 37.712 119.340 19.760 1.00 59.78 ? 71 LEU A CD1 1 ATOM 603 C CD2 . LEU A 1 79 ? 39.641 117.947 20.407 1.00 60.99 ? 71 LEU A CD2 1 ATOM 604 N N . THR A 1 80 ? 35.801 115.572 21.589 1.00 49.56 ? 72 THR A N 1 ATOM 605 C CA . THR A 1 80 ? 35.814 114.122 21.353 1.00 49.08 ? 72 THR A CA 1 ATOM 606 C C . THR A 1 80 ? 35.978 113.888 19.854 1.00 53.66 ? 72 THR A C 1 ATOM 607 O O . THR A 1 80 ? 35.154 114.350 19.044 1.00 54.60 ? 72 THR A O 1 ATOM 608 C CB . THR A 1 80 ? 34.604 113.369 21.986 1.00 54.50 ? 72 THR A CB 1 ATOM 609 O OG1 . THR A 1 80 ? 34.552 113.623 23.401 1.00 58.60 ? 72 THR A OG1 1 ATOM 610 C CG2 . THR A 1 80 ? 34.681 111.853 21.758 1.00 46.07 ? 72 THR A CG2 1 ATOM 611 N N . LEU A 1 81 ? 37.072 113.207 19.492 1.00 48.27 ? 73 LEU A N 1 ATOM 612 C CA . LEU A 1 81 ? 37.379 112.891 18.113 1.00 47.20 ? 73 LEU A CA 1 ATOM 613 C C . LEU A 1 81 ? 37.249 111.390 17.963 1.00 53.38 ? 73 LEU A C 1 ATOM 614 O O . LEU A 1 81 ? 38.051 110.630 18.528 1.00 50.33 ? 73 LEU A O 1 ATOM 615 C CB . LEU A 1 81 ? 38.772 113.402 17.717 1.00 46.64 ? 73 LEU A CB 1 ATOM 616 C CG . LEU A 1 81 ? 39.100 114.821 18.113 1.00 50.21 ? 73 LEU A CG 1 ATOM 617 C CD1 . LEU A 1 81 ? 40.586 115.038 18.110 1.00 51.15 ? 73 LEU A CD1 1 ATOM 618 C CD2 . LEU A 1 81 ? 38.402 115.818 17.215 1.00 49.54 ? 73 LEU A CD2 1 ATOM 619 N N . ARG A 1 82 ? 36.131 110.972 17.304 1.00 55.09 ? 74 ARG A N 1 ATOM 620 C CA . ARG A 1 82 ? 35.777 109.563 17.049 1.00 55.85 ? 74 ARG A CA 1 ATOM 621 C C . ARG A 1 82 ? 36.283 109.087 15.700 1.00 60.64 ? 74 ARG A C 1 ATOM 622 O O . ARG A 1 82 ? 35.588 109.159 14.683 1.00 61.55 ? 74 ARG A O 1 ATOM 623 C CB . ARG A 1 82 ? 34.270 109.297 17.175 1.00 54.40 ? 74 ARG A CB 1 ATOM 624 C CG . ARG A 1 82 ? 33.786 109.001 18.577 1.00 62.56 ? 74 ARG A CG 1 ATOM 625 C CD . ARG A 1 82 ? 32.278 109.183 18.688 1.00 61.57 ? 74 ARG A CD 1 ATOM 626 N NE . ARG A 1 82 ? 31.862 109.581 20.034 1.00 64.50 ? 74 ARG A NE 1 ATOM 627 C CZ . ARG A 1 82 ? 31.488 110.811 20.378 1.00 71.46 ? 74 ARG A CZ 1 ATOM 628 N NH1 . ARG A 1 82 ? 31.464 111.785 19.474 1.00 54.76 ? 74 ARG A NH1 1 ATOM 629 N NH2 . ARG A 1 82 ? 31.124 111.075 21.626 1.00 55.65 ? 74 ARG A NH2 1 ATOM 630 N N . TYR A 1 83 ? 37.514 108.636 15.686 1.00 56.67 ? 75 TYR A N 1 ATOM 631 C CA . TYR A 1 83 ? 38.045 108.043 14.494 1.00 57.26 ? 75 TYR A CA 1 ATOM 632 C C . TYR A 1 83 ? 37.517 106.603 14.560 1.00 65.37 ? 75 TYR A C 1 ATOM 633 O O . TYR A 1 83 ? 37.288 106.042 15.651 1.00 66.60 ? 75 TYR A O 1 ATOM 634 C CB . TYR A 1 83 ? 39.582 108.085 14.464 1.00 57.90 ? 75 TYR A CB 1 ATOM 635 C CG . TYR A 1 83 ? 40.195 109.465 14.624 1.00 59.01 ? 75 TYR A CG 1 ATOM 636 C CD1 . TYR A 1 83 ? 40.177 110.384 13.577 1.00 61.05 ? 75 TYR A CD1 1 ATOM 637 C CD2 . TYR A 1 83 ? 40.882 109.816 15.784 1.00 58.85 ? 75 TYR A CD2 1 ATOM 638 C CE1 . TYR A 1 83 ? 40.793 111.627 13.695 1.00 61.44 ? 75 TYR A CE1 1 ATOM 639 C CE2 . TYR A 1 83 ? 41.486 111.065 15.920 1.00 58.68 ? 75 TYR A CE2 1 ATOM 640 C CZ . TYR A 1 83 ? 41.447 111.963 14.869 1.00 63.29 ? 75 TYR A CZ 1 ATOM 641 O OH . TYR A 1 83 ? 42.048 113.191 14.984 1.00 60.89 ? 75 TYR A OH 1 ATOM 642 N N . SER A 1 84 ? 37.281 106.039 13.401 1.00 62.39 ? 76 SER A N 1 ATOM 643 C CA . SER A 1 84 ? 36.742 104.705 13.216 1.00 62.48 ? 76 SER A CA 1 ATOM 644 C C . SER A 1 84 ? 37.795 103.606 13.537 1.00 65.59 ? 76 SER A C 1 ATOM 645 O O . SER A 1 84 ? 37.481 102.405 13.558 1.00 64.71 ? 76 SER A O 1 ATOM 646 C CB . SER A 1 84 ? 36.188 104.590 11.799 1.00 67.73 ? 76 SER A CB 1 ATOM 647 O OG . SER A 1 84 ? 35.287 105.638 11.453 1.00 75.05 ? 76 SER A OG 1 ATOM 648 N N . THR A 1 85 ? 39.041 104.037 13.805 1.00 62.20 ? 77 THR A N 1 ATOM 649 C CA . THR A 1 85 ? 40.158 103.160 14.210 1.00 62.02 ? 77 THR A CA 1 ATOM 650 C C . THR A 1 85 ? 40.255 103.121 15.742 1.00 63.30 ? 77 THR A C 1 ATOM 651 O O . THR A 1 85 ? 40.799 102.163 16.317 1.00 63.64 ? 77 THR A O 1 ATOM 652 C CB . THR A 1 85 ? 41.501 103.697 13.670 1.00 72.60 ? 77 THR A CB 1 ATOM 653 O OG1 . THR A 1 85 ? 41.331 105.024 13.156 1.00 70.35 ? 77 THR A OG1 1 ATOM 654 C CG2 . THR A 1 85 ? 42.128 102.777 12.636 1.00 72.18 ? 77 THR A CG2 1 ATOM 655 N N . GLY A 1 86 ? 39.739 104.182 16.360 1.00 57.36 ? 78 GLY A N 1 ATOM 656 C CA . GLY A 1 86 ? 39.765 104.420 17.795 1.00 57.74 ? 78 GLY A CA 1 ATOM 657 C C . GLY A 1 86 ? 39.529 105.888 18.120 1.00 62.26 ? 78 GLY A C 1 ATOM 658 O O . GLY A 1 86 ? 39.962 106.776 17.375 1.00 61.79 ? 78 GLY A O 1 ATOM 659 N N . THR A 1 87 ? 38.891 106.143 19.278 1.00 57.19 ? 79 THR A N 1 ATOM 660 C CA . THR A 1 87 ? 38.463 107.457 19.745 1.00 55.77 ? 79 THR A CA 1 ATOM 661 C C . THR A 1 87 ? 39.449 108.088 20.747 1.00 58.11 ? 79 THR A C 1 ATOM 662 O O . THR A 1 87 ? 40.116 107.365 21.481 1.00 58.29 ? 79 THR A O 1 ATOM 663 C CB . THR A 1 87 ? 37.040 107.299 20.292 1.00 61.14 ? 79 THR A CB 1 ATOM 664 O OG1 . THR A 1 87 ? 36.261 106.678 19.264 1.00 65.99 ? 79 THR A OG1 1 ATOM 665 C CG2 . THR A 1 87 ? 36.390 108.618 20.751 1.00 56.58 ? 79 THR A CG2 1 ATOM 666 N N . VAL A 1 88 ? 39.557 109.448 20.734 1.00 50.80 ? 80 VAL A N 1 ATOM 667 C CA . VAL A 1 88 ? 40.358 110.269 21.650 1.00 47.94 ? 80 VAL A CA 1 ATOM 668 C C . VAL A 1 88 ? 39.504 111.417 22.152 1.00 48.59 ? 80 VAL A C 1 ATOM 669 O O . VAL A 1 88 ? 38.725 112.003 21.387 1.00 47.22 ? 80 VAL A O 1 ATOM 670 C CB . VAL A 1 88 ? 41.721 110.801 21.091 1.00 50.49 ? 80 VAL A CB 1 ATOM 671 C CG1 . VAL A 1 88 ? 42.657 109.662 20.707 1.00 49.32 ? 80 VAL A CG1 1 ATOM 672 C CG2 . VAL A 1 88 ? 41.541 111.800 19.932 1.00 50.26 ? 80 VAL A CG2 1 ATOM 673 N N . SER A 1 89 ? 39.686 111.776 23.419 1.00 43.46 ? 81 SER A N 1 ATOM 674 C CA . SER A 1 89 ? 39.002 112.924 23.993 1.00 42.57 ? 81 SER A CA 1 ATOM 675 C C . SER A 1 89 ? 39.926 113.717 24.930 1.00 46.84 ? 81 SER A C 1 ATOM 676 O O . SER A 1 89 ? 40.928 113.204 25.471 1.00 45.70 ? 81 SER A O 1 ATOM 677 C CB . SER A 1 89 ? 37.696 112.532 24.676 1.00 45.41 ? 81 SER A CB 1 ATOM 678 O OG . SER A 1 89 ? 37.935 111.664 25.768 1.00 57.28 ? 81 SER A OG 1 ATOM 679 N N . GLY A 1 90 ? 39.574 114.982 25.073 1.00 41.66 ? 82 GLY A N 1 ATOM 680 C CA . GLY A 1 90 ? 40.301 115.930 25.882 1.00 40.27 ? 82 GLY A CA 1 ATOM 681 C C . GLY A 1 90 ? 39.593 117.253 25.817 1.00 43.81 ? 82 GLY A C 1 ATOM 682 O O . GLY A 1 90 ? 38.358 117.295 25.845 1.00 45.36 ? 82 GLY A O 1 ATOM 683 N N . PHE A 1 91 ? 40.360 118.337 25.717 1.00 38.34 ? 83 PHE A N 1 ATOM 684 C CA . PHE A 1 91 ? 39.800 119.674 25.736 1.00 38.43 ? 83 PHE A CA 1 ATOM 685 C C . PHE A 1 91 ? 40.618 120.617 24.868 1.00 43.92 ? 83 PHE A C 1 ATOM 686 O O . PHE A 1 91 ? 41.788 120.365 24.625 1.00 44.28 ? 83 PHE A O 1 ATOM 687 C CB . PHE A 1 91 ? 39.718 120.179 27.203 1.00 39.94 ? 83 PHE A CB 1 ATOM 688 C CG . PHE A 1 91 ? 41.067 120.288 27.877 1.00 40.79 ? 83 PHE A CG 1 ATOM 689 C CD1 . PHE A 1 91 ? 41.621 119.196 28.538 1.00 42.54 ? 83 PHE A CD1 1 ATOM 690 C CD2 . PHE A 1 91 ? 41.819 121.464 27.783 1.00 41.65 ? 83 PHE A CD2 1 ATOM 691 C CE1 . PHE A 1 91 ? 42.894 119.280 29.104 1.00 43.16 ? 83 PHE A CE1 1 ATOM 692 C CE2 . PHE A 1 91 ? 43.085 121.547 28.353 1.00 43.72 ? 83 PHE A CE2 1 ATOM 693 C CZ . PHE A 1 91 ? 43.606 120.460 29.024 1.00 41.97 ? 83 PHE A CZ 1 ATOM 694 N N . LEU A 1 92 ? 40.017 121.729 24.478 1.00 41.43 ? 84 LEU A N 1 ATOM 695 C CA . LEU A 1 92 ? 40.634 122.738 23.632 1.00 42.41 ? 84 LEU A CA 1 ATOM 696 C C . LEU A 1 92 ? 41.589 123.679 24.348 1.00 44.92 ? 84 LEU A C 1 ATOM 697 O O . LEU A 1 92 ? 41.323 124.115 25.467 1.00 45.06 ? 84 LEU A O 1 ATOM 698 C CB . LEU A 1 92 ? 39.540 123.560 22.929 1.00 43.40 ? 84 LEU A CB 1 ATOM 699 C CG . LEU A 1 92 ? 38.828 122.873 21.762 1.00 49.12 ? 84 LEU A CG 1 ATOM 700 C CD1 . LEU A 1 92 ? 37.709 123.757 21.246 1.00 49.07 ? 84 LEU A CD1 1 ATOM 701 C CD2 . LEU A 1 92 ? 39.835 122.492 20.625 1.00 50.92 ? 84 LEU A CD2 1 ATOM 702 N N . SER A 1 93 ? 42.692 124.004 23.679 1.00 39.97 ? 85 SER A N 1 ATOM 703 C CA . SER A 1 93 ? 43.724 124.930 24.157 1.00 38.97 ? 85 SER A CA 1 ATOM 704 C C . SER A 1 93 ? 44.236 125.705 22.975 1.00 43.88 ? 85 SER A C 1 ATOM 705 O O . SER A 1 93 ? 44.123 125.245 21.830 1.00 43.56 ? 85 SER A O 1 ATOM 706 C CB . SER A 1 93 ? 44.894 124.182 24.789 1.00 38.04 ? 85 SER A CB 1 ATOM 707 O OG . SER A 1 93 ? 44.558 123.783 26.100 1.00 46.97 ? 85 SER A OG 1 ATOM 708 N N . GLN A 1 94 ? 44.857 126.845 23.255 1.00 39.68 ? 86 GLN A N 1 ATOM 709 C CA . GLN A 1 94 ? 45.473 127.645 22.213 1.00 39.31 ? 86 GLN A CA 1 ATOM 710 C C . GLN A 1 94 ? 46.936 127.907 22.595 1.00 43.27 ? 86 GLN A C 1 ATOM 711 O O . GLN A 1 94 ? 47.252 128.125 23.771 1.00 42.83 ? 86 GLN A O 1 ATOM 712 C CB . GLN A 1 94 ? 44.723 128.959 22.039 1.00 40.56 ? 86 GLN A CB 1 ATOM 713 C CG . GLN A 1 94 ? 45.090 129.687 20.764 1.00 55.46 ? 86 GLN A CG 1 ATOM 714 C CD . GLN A 1 94 ? 44.563 131.087 20.790 1.00 74.15 ? 86 GLN A CD 1 ATOM 715 O OE1 . GLN A 1 94 ? 45.258 132.030 21.157 1.00 69.82 ? 86 GLN A OE1 1 ATOM 716 N NE2 . GLN A 1 94 ? 43.318 131.257 20.388 1.00 71.23 ? 86 GLN A NE2 1 ATOM 717 N N . ASP A 1 95 ? 47.822 127.861 21.601 1.00 40.63 ? 87 ASP A N 1 ATOM 718 C CA . ASP A 1 95 ? 49.247 128.169 21.698 1.00 40.05 ? 87 ASP A CA 1 ATOM 719 C C . ASP A 1 95 ? 49.827 128.371 20.310 1.00 45.09 ? 87 ASP A C 1 ATOM 720 O O . ASP A 1 95 ? 49.132 128.161 19.321 1.00 44.76 ? 87 ASP A O 1 ATOM 721 C CB . ASP A 1 95 ? 50.000 127.065 22.421 1.00 41.79 ? 87 ASP A CB 1 ATOM 722 C CG . ASP A 1 95 ? 51.093 127.589 23.313 1.00 50.40 ? 87 ASP A CG 1 ATOM 723 O OD1 . ASP A 1 95 ? 51.772 128.549 22.913 1.00 50.97 ? 87 ASP A OD1 1 ATOM 724 O OD2 . ASP A 1 95 ? 51.326 126.986 24.372 1.00 54.41 ? 87 ASP A OD2 1 ATOM 725 N N . ILE A 1 96 ? 51.086 128.795 20.227 1.00 43.53 ? 88 ILE A N 1 ATOM 726 C CA . ILE A 1 96 ? 51.779 128.994 18.957 1.00 43.81 ? 88 ILE A CA 1 ATOM 727 C C . ILE A 1 96 ? 52.354 127.666 18.504 1.00 46.12 ? 88 ILE A C 1 ATOM 728 O O . ILE A 1 96 ? 53.049 127.011 19.279 1.00 47.44 ? 88 ILE A O 1 ATOM 729 C CB . ILE A 1 96 ? 52.859 130.105 19.057 1.00 47.94 ? 88 ILE A CB 1 ATOM 730 C CG1 . ILE A 1 96 ? 52.204 131.456 19.439 1.00 49.40 ? 88 ILE A CG1 1 ATOM 731 C CG2 . ILE A 1 96 ? 53.657 130.225 17.726 1.00 48.02 ? 88 ILE A CG2 1 ATOM 732 C CD1 . ILE A 1 96 ? 53.148 132.380 20.166 1.00 65.10 ? 88 ILE A CD1 1 ATOM 733 N N . ILE A 1 97 ? 52.041 127.269 17.256 1.00 40.31 ? 89 ILE A N 1 ATOM 734 C CA . ILE A 1 97 ? 52.521 126.055 16.607 1.00 39.11 ? 89 ILE A CA 1 ATOM 735 C C . ILE A 1 97 ? 53.525 126.414 15.499 1.00 45.93 ? 89 ILE A C 1 ATOM 736 O O . ILE A 1 97 ? 53.253 127.283 14.666 1.00 47.13 ? 89 ILE A O 1 ATOM 737 C CB . ILE A 1 97 ? 51.378 125.093 16.113 1.00 40.78 ? 89 ILE A CB 1 ATOM 738 C CG1 . ILE A 1 97 ? 50.457 124.673 17.289 1.00 39.89 ? 89 ILE A CG1 1 ATOM 739 C CG2 . ILE A 1 97 ? 51.961 123.855 15.357 1.00 38.55 ? 89 ILE A CG2 1 ATOM 740 C CD1 . ILE A 1 97 ? 49.396 123.650 16.990 1.00 39.64 ? 89 ILE A CD1 1 ATOM 741 N N . THR A 1 98 ? 54.682 125.750 15.509 1.00 43.66 ? 90 THR A N 1 ATOM 742 C CA . THR A 1 98 ? 55.715 125.916 14.495 1.00 44.60 ? 90 THR A CA 1 ATOM 743 C C . THR A 1 98 ? 55.692 124.690 13.583 1.00 51.26 ? 90 THR A C 1 ATOM 744 O O . THR A 1 98 ? 55.865 123.569 14.048 1.00 49.43 ? 90 THR A O 1 ATOM 745 C CB . THR A 1 98 ? 57.096 126.190 15.122 1.00 55.84 ? 90 THR A CB 1 ATOM 746 O OG1 . THR A 1 98 ? 57.047 127.430 15.833 1.00 57.08 ? 90 THR A OG1 1 ATOM 747 C CG2 . THR A 1 98 ? 58.186 126.260 14.078 1.00 55.23 ? 90 THR A CG2 1 ATOM 748 N N . VAL A 1 99 ? 55.446 124.929 12.291 1.00 51.10 ? 91 VAL A N 1 ATOM 749 C CA . VAL A 1 99 ? 55.380 123.921 11.238 1.00 51.47 ? 91 VAL A CA 1 ATOM 750 C C . VAL A 1 99 ? 56.184 124.471 10.042 1.00 58.90 ? 91 VAL A C 1 ATOM 751 O O . VAL A 1 99 ? 55.805 125.489 9.441 1.00 58.14 ? 91 VAL A O 1 ATOM 752 C CB . VAL A 1 99 ? 53.900 123.492 10.906 1.00 54.24 ? 91 VAL A CB 1 ATOM 753 C CG1 . VAL A 1 99 ? 52.999 124.690 10.685 1.00 53.25 ? 91 VAL A CG1 1 ATOM 754 C CG2 . VAL A 1 99 ? 53.820 122.544 9.710 1.00 54.01 ? 91 VAL A CG2 1 ATOM 755 N N . GLY A 1 100 ? 57.314 123.823 9.769 1.00 57.43 ? 92 GLY A N 1 ATOM 756 C CA . GLY A 1 100 ? 58.245 124.204 8.712 1.00 57.55 ? 92 GLY A CA 1 ATOM 757 C C . GLY A 1 100 ? 58.627 125.677 8.677 1.00 60.60 ? 92 GLY A C 1 ATOM 758 O O . GLY A 1 100 ? 58.656 126.275 7.597 1.00 59.44 ? 92 GLY A O 1 ATOM 759 N N . GLY A 1 101 ? 58.935 126.267 9.818 1.00 57.91 ? 93 GLY A N 1 ATOM 760 C CA . GLY A 1 101 ? 59.303 127.682 9.816 1.00 58.84 ? 93 GLY A CA 1 ATOM 761 C C . GLY A 1 101 ? 58.133 128.616 10.047 1.00 63.17 ? 93 GLY A C 1 ATOM 762 O O . GLY A 1 101 ? 58.285 129.626 10.752 1.00 64.13 ? 93 GLY A O 1 ATOM 763 N N . ILE A 1 102 ? 56.941 128.268 9.481 1.00 56.56 ? 94 ILE A N 1 ATOM 764 C CA . ILE A 1 102 ? 55.702 129.013 9.707 1.00 54.47 ? 94 ILE A CA 1 ATOM 765 C C . ILE A 1 102 ? 55.292 128.858 11.167 1.00 57.58 ? 94 ILE A C 1 ATOM 766 O O . ILE A 1 102 ? 55.138 127.739 11.674 1.00 57.81 ? 94 ILE A O 1 ATOM 767 C CB . ILE A 1 102 ? 54.542 128.576 8.790 1.00 56.38 ? 94 ILE A CB 1 ATOM 768 C CG1 . ILE A 1 102 ? 54.911 128.673 7.302 1.00 56.17 ? 94 ILE A CG1 1 ATOM 769 C CG2 . ILE A 1 102 ? 53.254 129.342 9.129 1.00 54.45 ? 94 ILE A CG2 1 ATOM 770 C CD1 . ILE A 1 102 ? 54.034 127.767 6.436 1.00 57.31 ? 94 ILE A CD1 1 ATOM 771 N N . THR A 1 103 ? 55.140 129.999 11.826 1.00 53.06 ? 95 THR A N 1 ATOM 772 C CA . THR A 1 103 ? 54.682 130.167 13.196 1.00 52.10 ? 95 THR A CA 1 ATOM 773 C C . THR A 1 103 ? 53.218 130.648 13.106 1.00 56.81 ? 95 THR A C 1 ATOM 774 O O . THR A 1 103 ? 52.922 131.667 12.464 1.00 57.26 ? 95 THR A O 1 ATOM 775 C CB . THR A 1 103 ? 55.667 131.090 13.916 1.00 57.34 ? 95 THR A CB 1 ATOM 776 O OG1 . THR A 1 103 ? 56.662 130.294 14.553 1.00 56.56 ? 95 THR A OG1 1 ATOM 777 C CG2 . THR A 1 103 ? 55.019 131.984 14.920 1.00 61.37 ? 95 THR A CG2 1 ATOM 778 N N . VAL A 1 104 ? 52.306 129.899 13.725 1.00 52.83 ? 96 VAL A N 1 ATOM 779 C CA . VAL A 1 104 ? 50.880 130.224 13.695 1.00 52.09 ? 96 VAL A CA 1 ATOM 780 C C . VAL A 1 104 ? 50.214 130.032 15.075 1.00 55.29 ? 96 VAL A C 1 ATOM 781 O O . VAL A 1 104 ? 50.505 129.046 15.761 1.00 56.25 ? 96 VAL A O 1 ATOM 782 C CB . VAL A 1 104 ? 50.158 129.443 12.543 1.00 56.18 ? 96 VAL A CB 1 ATOM 783 C CG1 . VAL A 1 104 ? 50.226 127.922 12.727 1.00 56.60 ? 96 VAL A CG1 1 ATOM 784 C CG2 . VAL A 1 104 ? 48.725 129.891 12.368 1.00 55.98 ? 96 VAL A CG2 1 ATOM 785 N N . THR A 1 105 ? 49.338 130.983 15.494 1.00 49.65 ? 97 THR A N 1 ATOM 786 C CA . THR A 1 105 ? 48.555 130.814 16.730 1.00 47.88 ? 97 THR A CA 1 ATOM 787 C C . THR A 1 105 ? 47.434 129.870 16.316 1.00 49.29 ? 97 THR A C 1 ATOM 788 O O . THR A 1 105 ? 46.722 130.156 15.357 1.00 50.32 ? 97 THR A O 1 ATOM 789 C CB . THR A 1 105 ? 47.973 132.123 17.264 1.00 45.22 ? 97 THR A CB 1 ATOM 790 O OG1 . THR A 1 105 ? 48.986 133.122 17.319 1.00 50.39 ? 97 THR A OG1 1 ATOM 791 C CG2 . THR A 1 105 ? 47.353 131.951 18.621 1.00 31.86 ? 97 THR A CG2 1 ATOM 792 N N . GLN A 1 106 ? 47.329 128.736 16.996 1.00 43.01 ? 99 GLN A N 1 ATOM 793 C CA . GLN A 1 106 ? 46.391 127.661 16.685 1.00 41.62 ? 99 GLN A CA 1 ATOM 794 C C . GLN A 1 106 ? 45.700 127.076 17.926 1.00 45.13 ? 99 GLN A C 1 ATOM 795 O O . GLN A 1 106 ? 46.317 126.893 18.986 1.00 42.40 ? 99 GLN A O 1 ATOM 796 C CB . GLN A 1 106 ? 47.172 126.543 15.945 1.00 42.49 ? 99 GLN A CB 1 ATOM 797 C CG . GLN A 1 106 ? 46.374 125.329 15.474 1.00 48.00 ? 99 GLN A CG 1 ATOM 798 C CD . GLN A 1 106 ? 45.400 125.678 14.393 1.00 52.27 ? 99 GLN A CD 1 ATOM 799 O OE1 . GLN A 1 106 ? 45.663 126.543 13.550 1.00 43.21 ? 99 GLN A OE1 1 ATOM 800 N NE2 . GLN A 1 106 ? 44.242 125.016 14.425 1.00 43.66 ? 99 GLN A NE2 1 ATOM 801 N N . MET A 1 107 ? 44.416 126.752 17.742 1.00 43.32 ? 100 MET A N 1 ATOM 802 C CA . MET A 1 107 ? 43.568 126.087 18.710 1.00 44.87 ? 100 MET A CA 1 ATOM 803 C C . MET A 1 107 ? 43.693 124.570 18.422 1.00 45.42 ? 100 MET A C 1 ATOM 804 O O . MET A 1 107 ? 43.549 124.114 17.275 1.00 46.71 ? 100 MET A O 1 ATOM 805 C CB . MET A 1 107 ? 42.127 126.553 18.537 1.00 49.25 ? 100 MET A CB 1 ATOM 806 C CG . MET A 1 107 ? 41.231 126.193 19.698 1.00 56.88 ? 100 MET A CG 1 ATOM 807 S SD . MET A 1 107 ? 41.184 127.471 20.987 1.00 66.14 ? 100 MET A SD 1 ATOM 808 C CE . MET A 1 107 ? 40.548 128.906 20.051 1.00 62.63 ? 100 MET A CE 1 ATOM 809 N N . PHE A 1 108 ? 43.995 123.801 19.445 1.00 37.64 ? 101 PHE A N 1 ATOM 810 C CA . PHE A 1 108 ? 44.185 122.364 19.305 1.00 36.37 ? 101 PHE A CA 1 ATOM 811 C C . PHE A 1 108 ? 43.617 121.643 20.534 1.00 41.05 ? 101 PHE A C 1 ATOM 812 O O . PHE A 1 108 ? 43.359 122.271 21.559 1.00 42.99 ? 101 PHE A O 1 ATOM 813 C CB . PHE A 1 108 ? 45.708 122.049 19.108 1.00 37.72 ? 101 PHE A CB 1 ATOM 814 C CG . PHE A 1 108 ? 46.582 122.429 20.288 1.00 37.34 ? 101 PHE A CG 1 ATOM 815 C CD1 . PHE A 1 108 ? 47.006 123.748 20.468 1.00 39.33 ? 101 PHE A CD1 1 ATOM 816 C CD2 . PHE A 1 108 ? 46.917 121.491 21.254 1.00 35.47 ? 101 PHE A CD2 1 ATOM 817 C CE1 . PHE A 1 108 ? 47.751 124.117 21.593 1.00 39.17 ? 101 PHE A CE1 1 ATOM 818 C CE2 . PHE A 1 108 ? 47.652 121.861 22.380 1.00 38.31 ? 101 PHE A CE2 1 ATOM 819 C CZ . PHE A 1 108 ? 48.074 123.172 22.539 1.00 37.31 ? 101 PHE A CZ 1 ATOM 820 N N . GLY A 1 109 ? 43.465 120.333 20.431 1.00 37.15 ? 102 GLY A N 1 ATOM 821 C CA . GLY A 1 109 ? 42.980 119.517 21.530 1.00 37.32 ? 102 GLY A CA 1 ATOM 822 C C . GLY A 1 109 ? 44.113 118.939 22.348 1.00 43.99 ? 102 GLY A C 1 ATOM 823 O O . GLY A 1 109 ? 45.124 118.475 21.805 1.00 44.71 ? 102 GLY A O 1 ATOM 824 N N . GLU A 1 110 ? 43.958 118.998 23.662 1.00 40.95 ? 103 GLU A N 1 ATOM 825 C CA . GLU A 1 110 ? 44.867 118.417 24.628 1.00 40.99 ? 103 GLU A CA 1 ATOM 826 C C . GLU A 1 110 ? 44.173 117.126 25.033 1.00 44.65 ? 103 GLU A C 1 ATOM 827 O O . GLU A 1 110 ? 43.179 117.178 25.747 1.00 44.56 ? 103 GLU A O 1 ATOM 828 C CB . GLU A 1 110 ? 45.050 119.357 25.826 1.00 42.44 ? 103 GLU A CB 1 ATOM 829 C CG . GLU A 1 110 ? 46.409 120.039 25.828 1.00 48.32 ? 103 GLU A CG 1 ATOM 830 C CD . GLU A 1 110 ? 46.668 120.896 27.051 1.00 57.54 ? 103 GLU A CD 1 ATOM 831 O OE1 . GLU A 1 110 ? 46.401 122.116 26.973 1.00 40.49 ? 103 GLU A OE1 1 ATOM 832 O OE2 . GLU A 1 110 ? 47.095 120.348 28.095 1.00 37.11 ? 103 GLU A OE2 1 ATOM 833 N N . VAL A 1 111 ? 44.641 115.979 24.492 1.00 39.64 ? 104 VAL A N 1 ATOM 834 C CA . VAL A 1 111 ? 44.029 114.665 24.687 1.00 37.94 ? 104 VAL A CA 1 ATOM 835 C C . VAL A 1 111 ? 44.379 114.089 26.067 1.00 44.53 ? 104 VAL A C 1 ATOM 836 O O . VAL A 1 111 ? 45.553 113.968 26.425 1.00 43.28 ? 104 VAL A O 1 ATOM 837 C CB . VAL A 1 111 ? 44.351 113.727 23.497 1.00 39.18 ? 104 VAL A CB 1 ATOM 838 C CG1 . VAL A 1 111 ? 44.221 112.256 23.863 1.00 38.70 ? 104 VAL A CG1 1 ATOM 839 C CG2 . VAL A 1 111 ? 43.476 114.068 22.301 1.00 38.48 ? 104 VAL A CG2 1 ATOM 840 N N . THR A 1 112 ? 43.330 113.735 26.833 1.00 43.41 ? 105 THR A N 1 ATOM 841 C CA . THR A 1 112 ? 43.442 113.187 28.191 1.00 43.29 ? 105 THR A CA 1 ATOM 842 C C . THR A 1 112 ? 43.000 111.715 28.259 1.00 46.90 ? 105 THR A C 1 ATOM 843 O O . THR A 1 112 ? 43.257 111.046 29.258 1.00 46.17 ? 105 THR A O 1 ATOM 844 C CB . THR A 1 112 ? 42.708 114.096 29.201 1.00 47.32 ? 105 THR A CB 1 ATOM 845 O OG1 . THR A 1 112 ? 41.329 114.176 28.863 1.00 47.08 ? 105 THR A OG1 1 ATOM 846 C CG2 . THR A 1 112 ? 43.307 115.500 29.273 1.00 46.02 ? 105 THR A CG2 1 ATOM 847 N N . GLU A 1 113 ? 42.331 111.223 27.209 1.00 44.37 ? 106 GLU A N 1 ATOM 848 C CA . GLU A 1 113 ? 41.881 109.827 27.102 1.00 44.41 ? 106 GLU A CA 1 ATOM 849 C C . GLU A 1 113 ? 42.356 109.320 25.755 1.00 47.74 ? 106 GLU A C 1 ATOM 850 O O . GLU A 1 113 ? 41.870 109.740 24.707 1.00 44.67 ? 106 GLU A O 1 ATOM 851 C CB . GLU A 1 113 ? 40.354 109.699 27.263 1.00 45.71 ? 106 GLU A CB 1 ATOM 852 C CG . GLU A 1 113 ? 39.865 110.084 28.651 1.00 57.42 ? 106 GLU A CG 1 ATOM 853 C CD . GLU A 1 113 ? 38.373 110.321 28.746 1.00 87.87 ? 106 GLU A CD 1 ATOM 854 O OE1 . GLU A 1 113 ? 37.632 109.330 28.923 1.00 86.39 ? 106 GLU A OE1 1 ATOM 855 O OE2 . GLU A 1 113 ? 37.941 111.494 28.646 1.00 89.52 ? 106 GLU A OE2 1 ATOM 856 N N . MET A 1 114 ? 43.368 108.474 25.798 1.00 48.05 ? 107 MET A N 1 ATOM 857 C CA . MET A 1 114 ? 44.062 107.947 24.630 1.00 49.05 ? 107 MET A CA 1 ATOM 858 C C . MET A 1 114 ? 44.217 106.409 24.772 1.00 52.17 ? 107 MET A C 1 ATOM 859 O O . MET A 1 114 ? 45.111 105.939 25.495 1.00 51.18 ? 107 MET A O 1 ATOM 860 C CB . MET A 1 114 ? 45.419 108.676 24.555 1.00 51.73 ? 107 MET A CB 1 ATOM 861 C CG . MET A 1 114 ? 46.260 108.365 23.361 1.00 55.77 ? 107 MET A CG 1 ATOM 862 S SD . MET A 1 114 ? 47.635 109.512 23.470 1.00 59.60 ? 107 MET A SD 1 ATOM 863 C CE . MET A 1 114 ? 48.631 108.932 22.222 1.00 55.94 ? 107 MET A CE 1 ATOM 864 N N . PRO A 1 115 ? 43.310 105.623 24.123 1.00 47.95 ? 108 PRO A N 1 ATOM 865 C CA . PRO A 1 115 ? 43.354 104.161 24.263 1.00 46.79 ? 108 PRO A CA 1 ATOM 866 C C . PRO A 1 115 ? 44.594 103.484 23.702 1.00 51.64 ? 108 PRO A C 1 ATOM 867 O O . PRO A 1 115 ? 45.065 103.811 22.600 1.00 50.84 ? 108 PRO A O 1 ATOM 868 C CB . PRO A 1 115 ? 42.076 103.694 23.561 1.00 47.48 ? 108 PRO A CB 1 ATOM 869 C CG . PRO A 1 115 ? 41.755 104.743 22.615 1.00 52.52 ? 108 PRO A CG 1 ATOM 870 C CD . PRO A 1 115 ? 42.175 106.025 23.274 1.00 49.18 ? 108 PRO A CD 1 ATOM 871 N N . ALA A 1 116 ? 45.083 102.491 24.472 1.00 49.00 ? 109 ALA A N 1 ATOM 872 C CA . ALA A 1 116 ? 46.220 101.641 24.131 1.00 49.30 ? 109 ALA A CA 1 ATOM 873 C C . ALA A 1 116 ? 46.084 101.096 22.698 1.00 55.35 ? 109 ALA A C 1 ATOM 874 O O . ALA A 1 116 ? 47.081 100.968 21.985 1.00 55.45 ? 109 ALA A O 1 ATOM 875 C CB . ALA A 1 116 ? 46.315 100.498 25.125 1.00 49.84 ? 109 ALA A CB 1 ATOM 876 N N . LEU A 1 117 ? 44.844 100.822 22.271 1.00 51.45 ? 110 LEU A N 1 ATOM 877 C CA . LEU A 1 117 ? 44.566 100.372 20.926 1.00 51.49 ? 110 LEU A CA 1 ATOM 878 C C . LEU A 1 117 ? 43.854 101.480 20.185 1.00 54.12 ? 110 LEU A C 1 ATOM 879 O O . LEU A 1 117 ? 42.772 101.901 20.584 1.00 55.38 ? 110 LEU A O 1 ATOM 880 C CB . LEU A 1 117 ? 43.760 99.082 20.962 1.00 52.71 ? 110 LEU A CB 1 ATOM 881 C CG . LEU A 1 117 ? 44.628 97.839 21.198 1.00 59.05 ? 110 LEU A CG 1 ATOM 882 C CD1 . LEU A 1 117 ? 43.872 96.771 21.983 1.00 59.43 ? 110 LEU A CD1 1 ATOM 883 C CD2 . LEU A 1 117 ? 45.136 97.296 19.883 1.00 63.55 ? 110 LEU A CD2 1 ATOM 884 N N . PRO A 1 118 ? 44.489 102.106 19.198 1.00 47.97 ? 111 PRO A N 1 ATOM 885 C CA . PRO A 1 118 ? 45.748 101.740 18.539 1.00 46.71 ? 111 PRO A CA 1 ATOM 886 C C . PRO A 1 118 ? 47.004 102.538 18.922 1.00 49.09 ? 111 PRO A C 1 ATOM 887 O O . PRO A 1 118 ? 48.065 102.241 18.384 1.00 48.59 ? 111 PRO A O 1 ATOM 888 C CB . PRO A 1 118 ? 45.397 102.002 17.072 1.00 47.88 ? 111 PRO A CB 1 ATOM 889 C CG . PRO A 1 118 ? 44.549 103.259 17.135 1.00 52.23 ? 111 PRO A CG 1 ATOM 890 C CD . PRO A 1 118 ? 43.798 103.181 18.457 1.00 48.43 ? 111 PRO A CD 1 ATOM 891 N N . PHE A 1 119 ? 46.901 103.521 19.844 1.00 43.59 ? 112 PHE A N 1 ATOM 892 C CA . PHE A 1 119 ? 47.975 104.461 20.155 1.00 42.16 ? 112 PHE A CA 1 ATOM 893 C C . PHE A 1 119 ? 49.235 103.846 20.777 1.00 46.91 ? 112 PHE A C 1 ATOM 894 O O . PHE A 1 119 ? 50.285 104.462 20.658 1.00 44.77 ? 112 PHE A O 1 ATOM 895 C CB . PHE A 1 119 ? 47.452 105.656 20.962 1.00 42.84 ? 112 PHE A CB 1 ATOM 896 C CG . PHE A 1 119 ? 46.358 106.332 20.148 1.00 42.77 ? 112 PHE A CG 1 ATOM 897 C CD1 . PHE A 1 119 ? 46.661 107.003 18.970 1.00 43.16 ? 112 PHE A CD1 1 ATOM 898 C CD2 . PHE A 1 119 ? 45.016 106.156 20.471 1.00 43.53 ? 112 PHE A CD2 1 ATOM 899 C CE1 . PHE A 1 119 ? 45.647 107.531 18.168 1.00 43.33 ? 112 PHE A CE1 1 ATOM 900 C CE2 . PHE A 1 119 ? 44.006 106.670 19.654 1.00 44.55 ? 112 PHE A CE2 1 ATOM 901 C CZ . PHE A 1 119 ? 44.328 107.360 18.516 1.00 41.58 ? 112 PHE A CZ 1 ATOM 902 N N . MET A 1 120 ? 49.197 102.595 21.268 1.00 45.61 ? 113 MET A N 1 ATOM 903 C CA . MET A 1 120 ? 50.416 101.952 21.787 1.00 44.81 ? 113 MET A CA 1 ATOM 904 C C . MET A 1 120 ? 51.295 101.519 20.639 1.00 49.18 ? 113 MET A C 1 ATOM 905 O O . MET A 1 120 ? 52.510 101.368 20.814 1.00 49.48 ? 113 MET A O 1 ATOM 906 C CB . MET A 1 120 ? 50.124 100.797 22.742 1.00 47.15 ? 113 MET A CB 1 ATOM 907 C CG . MET A 1 120 ? 50.029 101.250 24.199 1.00 51.97 ? 113 MET A CG 1 ATOM 908 S SD . MET A 1 120 ? 51.552 102.009 24.868 1.00 57.54 ? 113 MET A SD 1 ATOM 909 C CE . MET A 1 120 ? 52.590 100.504 25.035 1.00 54.03 ? 113 MET A CE 1 ATOM 910 N N . LEU A 1 121 ? 50.674 101.378 19.446 1.00 45.13 ? 114 LEU A N 1 ATOM 911 C CA . LEU A 1 121 ? 51.302 100.995 18.184 1.00 44.94 ? 114 LEU A CA 1 ATOM 912 C C . LEU A 1 121 ? 51.722 102.234 17.418 1.00 47.58 ? 114 LEU A C 1 ATOM 913 O O . LEU A 1 121 ? 52.436 102.115 16.423 1.00 47.27 ? 114 LEU A O 1 ATOM 914 C CB . LEU A 1 121 ? 50.325 100.214 17.296 1.00 46.09 ? 114 LEU A CB 1 ATOM 915 C CG . LEU A 1 121 ? 49.499 99.084 17.914 1.00 52.24 ? 114 LEU A CG 1 ATOM 916 C CD1 . LEU A 1 121 ? 48.207 98.866 17.103 1.00 53.87 ? 114 LEU A CD1 1 ATOM 917 C CD2 . LEU A 1 121 ? 50.318 97.795 18.066 1.00 48.96 ? 114 LEU A CD2 1 ATOM 918 N N . ALA A 1 122 ? 51.238 103.421 17.841 1.00 42.35 ? 115 ALA A N 1 ATOM 919 C CA . ALA A 1 122 ? 51.552 104.694 17.190 1.00 41.13 ? 115 ALA A CA 1 ATOM 920 C C . ALA A 1 122 ? 52.995 105.154 17.502 1.00 43.94 ? 115 ALA A C 1 ATOM 921 O O . ALA A 1 122 ? 53.394 105.194 18.668 1.00 41.56 ? 115 ALA A O 1 ATOM 922 C CB . ALA A 1 122 ? 50.551 105.768 17.602 1.00 41.55 ? 115 ALA A CB 1 ATOM 923 N N . GLU A 1 123 ? 53.795 105.432 16.444 1.00 40.57 ? 116 GLU A N 1 ATOM 924 C CA . GLU A 1 123 ? 55.136 106.015 16.577 1.00 39.85 ? 116 GLU A CA 1 ATOM 925 C C . GLU A 1 123 ? 54.949 107.539 16.781 1.00 42.44 ? 116 GLU A C 1 ATOM 926 O O . GLU A 1 123 ? 55.728 108.159 17.487 1.00 44.96 ? 116 GLU A O 1 ATOM 927 C CB . GLU A 1 123 ? 56.001 105.766 15.324 1.00 40.86 ? 116 GLU A CB 1 ATOM 928 C CG . GLU A 1 123 ? 57.047 104.682 15.467 1.00 47.76 ? 116 GLU A CG 1 ATOM 929 C CD . GLU A 1 123 ? 58.194 104.889 16.438 1.00 74.80 ? 116 GLU A CD 1 ATOM 930 O OE1 . GLU A 1 123 ? 58.871 103.883 16.751 1.00 77.58 ? 116 GLU A OE1 1 ATOM 931 O OE2 . GLU A 1 123 ? 58.457 106.046 16.844 1.00 77.04 ? 116 GLU A OE2 1 ATOM 932 N N . PHE A 1 124 ? 53.912 108.124 16.175 1.00 35.43 ? 117 PHE A N 1 ATOM 933 C CA . PHE A 1 124 ? 53.575 109.546 16.281 1.00 34.58 ? 117 PHE A CA 1 ATOM 934 C C . PHE A 1 124 ? 52.879 109.785 17.604 1.00 37.73 ? 117 PHE A C 1 ATOM 935 O O . PHE A 1 124 ? 52.280 108.843 18.145 1.00 39.11 ? 117 PHE A O 1 ATOM 936 C CB . PHE A 1 124 ? 52.638 109.969 15.113 1.00 35.58 ? 117 PHE A CB 1 ATOM 937 C CG . PHE A 1 124 ? 51.367 109.151 14.969 1.00 36.11 ? 117 PHE A CG 1 ATOM 938 C CD1 . PHE A 1 124 ? 51.383 107.913 14.337 1.00 37.38 ? 117 PHE A CD1 1 ATOM 939 C CD2 . PHE A 1 124 ? 50.153 109.628 15.446 1.00 36.94 ? 117 PHE A CD2 1 ATOM 940 C CE1 . PHE A 1 124 ? 50.208 107.167 14.192 1.00 37.35 ? 117 PHE A CE1 1 ATOM 941 C CE2 . PHE A 1 124 ? 48.978 108.876 15.300 1.00 38.69 ? 117 PHE A CE2 1 ATOM 942 C CZ . PHE A 1 124 ? 49.010 107.658 14.666 1.00 35.73 ? 117 PHE A CZ 1 ATOM 943 N N . ASP A 1 125 ? 52.897 111.042 18.087 1.00 31.84 ? 118 ASP A N 1 ATOM 944 C CA . ASP A 1 125 ? 52.251 111.440 19.327 1.00 31.18 ? 118 ASP A CA 1 ATOM 945 C C . ASP A 1 125 ? 50.835 111.906 19.063 1.00 35.15 ? 118 ASP A C 1 ATOM 946 O O . ASP A 1 125 ? 49.907 111.480 19.774 1.00 36.12 ? 118 ASP A O 1 ATOM 947 C CB . ASP A 1 125 ? 53.036 112.562 20.037 1.00 32.70 ? 118 ASP A CB 1 ATOM 948 C CG . ASP A 1 125 ? 54.489 112.246 20.283 1.00 36.60 ? 118 ASP A CG 1 ATOM 949 O OD1 . ASP A 1 125 ? 54.766 111.237 20.964 1.00 36.55 ? 118 ASP A OD1 1 ATOM 950 O OD2 . ASP A 1 125 ? 55.349 113.018 19.812 1.00 36.66 ? 118 ASP A OD2 1 ATOM 951 N N . GLY A 1 126 ? 50.687 112.788 18.067 1.00 29.61 ? 119 GLY A N 1 ATOM 952 C CA . GLY A 1 126 ? 49.401 113.379 17.712 1.00 29.39 ? 119 GLY A CA 1 ATOM 953 C C . GLY A 1 126 ? 49.093 113.488 16.235 1.00 33.45 ? 119 GLY A C 1 ATOM 954 O O . GLY A 1 126 ? 49.687 112.803 15.409 1.00 31.88 ? 119 GLY A O 1 ATOM 955 N N . VAL A 1 127 ? 48.120 114.342 15.903 1.00 32.54 ? 120 VAL A N 1 ATOM 956 C CA . VAL A 1 127 ? 47.603 114.521 14.544 1.00 32.68 ? 120 VAL A CA 1 ATOM 957 C C . VAL A 1 127 ? 47.443 115.985 14.192 1.00 38.15 ? 120 VAL A C 1 ATOM 958 O O . VAL A 1 127 ? 46.998 116.771 15.024 1.00 39.19 ? 120 VAL A O 1 ATOM 959 C CB . VAL A 1 127 ? 46.235 113.764 14.404 1.00 36.68 ? 120 VAL A CB 1 ATOM 960 C CG1 . VAL A 1 127 ? 45.636 113.903 12.988 1.00 36.56 ? 120 VAL A CG1 1 ATOM 961 C CG2 . VAL A 1 127 ? 46.365 112.284 14.791 1.00 35.75 ? 120 VAL A CG2 1 ATOM 962 N N . VAL A 1 128 ? 47.750 116.333 12.943 1.00 36.22 ? 121 VAL A N 1 ATOM 963 C CA . VAL A 1 128 ? 47.539 117.668 12.371 1.00 36.99 ? 121 VAL A CA 1 ATOM 964 C C . VAL A 1 128 ? 46.578 117.437 11.201 1.00 41.69 ? 121 VAL A C 1 ATOM 965 O O . VAL A 1 128 ? 46.973 116.864 10.180 1.00 40.64 ? 121 VAL A O 1 ATOM 966 C CB . VAL A 1 128 ? 48.863 118.395 11.953 1.00 39.84 ? 121 VAL A CB 1 ATOM 967 C CG1 . VAL A 1 128 ? 48.590 119.554 10.991 1.00 39.11 ? 121 VAL A CG1 1 ATOM 968 C CG2 . VAL A 1 128 ? 49.622 118.879 13.179 1.00 38.98 ? 121 VAL A CG2 1 ATOM 969 N N . GLY A 1 129 ? 45.298 117.747 11.424 1.00 38.27 ? 122 GLY A N 1 ATOM 970 C CA . GLY A 1 129 ? 44.277 117.592 10.396 1.00 36.72 ? 122 GLY A CA 1 ATOM 971 C C . GLY A 1 129 ? 44.477 118.611 9.292 1.00 37.14 ? 122 GLY A C 1 ATOM 972 O O . GLY A 1 129 ? 44.631 119.797 9.590 1.00 33.81 ? 122 GLY A O 1 ATOM 973 N N . MET A 1 130 ? 44.518 118.145 8.021 1.00 35.53 ? 123 MET A N 1 ATOM 974 C CA . MET A 1 130 ? 44.733 118.937 6.795 1.00 37.08 ? 123 MET A CA 1 ATOM 975 C C . MET A 1 130 ? 43.424 119.066 5.997 1.00 43.57 ? 123 MET A C 1 ATOM 976 O O . MET A 1 130 ? 43.417 119.587 4.875 1.00 42.91 ? 123 MET A O 1 ATOM 977 C CB . MET A 1 130 ? 45.871 118.343 5.917 1.00 39.59 ? 123 MET A CB 1 ATOM 978 C CG . MET A 1 130 ? 47.250 118.316 6.579 1.00 43.30 ? 123 MET A CG 1 ATOM 979 S SD . MET A 1 130 ? 47.864 119.925 7.134 1.00 48.07 ? 123 MET A SD 1 ATOM 980 C CE . MET A 1 130 ? 48.300 120.714 5.558 1.00 43.54 ? 123 MET A CE 1 ATOM 981 N N . GLY A 1 131 ? 42.333 118.599 6.599 1.00 41.98 ? 124 GLY A N 1 ATOM 982 C CA . GLY A 1 131 ? 40.992 118.707 6.045 1.00 43.22 ? 124 GLY A CA 1 ATOM 983 C C . GLY A 1 131 ? 40.392 120.109 6.164 1.00 48.97 ? 124 GLY A C 1 ATOM 984 O O . GLY A 1 131 ? 41.087 121.075 6.507 1.00 48.53 ? 124 GLY A O 1 ATOM 985 N N . PHE A 1 132 ? 39.086 120.229 5.851 1.00 47.58 ? 125 PHE A N 1 ATOM 986 C CA . PHE A 1 132 ? 38.364 121.515 5.839 1.00 47.94 ? 125 PHE A CA 1 ATOM 987 C C . PHE A 1 132 ? 37.611 121.781 7.142 1.00 53.64 ? 125 PHE A C 1 ATOM 988 O O . PHE A 1 132 ? 37.234 120.829 7.830 1.00 53.88 ? 125 PHE A O 1 ATOM 989 C CB . PHE A 1 132 ? 37.373 121.556 4.674 1.00 48.75 ? 125 PHE A CB 1 ATOM 990 C CG . PHE A 1 132 ? 37.905 121.387 3.272 1.00 48.71 ? 125 PHE A CG 1 ATOM 991 C CD1 . PHE A 1 132 ? 38.303 120.135 2.804 1.00 50.60 ? 125 PHE A CD1 1 ATOM 992 C CD2 . PHE A 1 132 ? 37.924 122.461 2.387 1.00 49.25 ? 125 PHE A CD2 1 ATOM 993 C CE1 . PHE A 1 132 ? 38.739 119.970 1.485 1.00 51.03 ? 125 PHE A CE1 1 ATOM 994 C CE2 . PHE A 1 132 ? 38.352 122.297 1.068 1.00 51.29 ? 125 PHE A CE2 1 ATOM 995 C CZ . PHE A 1 132 ? 38.778 121.059 0.632 1.00 49.88 ? 125 PHE A CZ 1 ATOM 996 N N . ILE A 1 133 ? 37.312 123.070 7.428 1.00 50.69 ? 126 ILE A N 1 ATOM 997 C CA . ILE A 1 133 ? 36.582 123.512 8.638 1.00 51.09 ? 126 ILE A CA 1 ATOM 998 C C . ILE A 1 133 ? 35.250 122.775 8.807 1.00 56.98 ? 126 ILE A C 1 ATOM 999 O O . ILE A 1 133 ? 34.905 122.431 9.930 1.00 57.31 ? 126 ILE A O 1 ATOM 1000 C CB . ILE A 1 133 ? 36.440 125.060 8.714 1.00 53.91 ? 126 ILE A CB 1 ATOM 1001 C CG1 . ILE A 1 133 ? 36.043 125.516 10.139 1.00 53.64 ? 126 ILE A CG1 1 ATOM 1002 C CG2 . ILE A 1 133 ? 35.522 125.632 7.622 1.00 54.63 ? 126 ILE A CG2 1 ATOM 1003 C CD1 . ILE A 1 133 ? 36.459 126.909 10.496 1.00 61.45 ? 126 ILE A CD1 1 ATOM 1004 N N . GLU A 1 134 ? 34.576 122.435 7.691 1.00 55.02 ? 127 GLU A N 1 ATOM 1005 C CA . GLU A 1 134 ? 33.315 121.682 7.652 1.00 55.36 ? 127 GLU A CA 1 ATOM 1006 C C . GLU A 1 134 ? 33.391 120.336 8.390 1.00 61.31 ? 127 GLU A C 1 ATOM 1007 O O . GLU A 1 134 ? 32.368 119.862 8.890 1.00 63.05 ? 127 GLU A O 1 ATOM 1008 C CB . GLU A 1 134 ? 32.861 121.457 6.194 1.00 56.60 ? 127 GLU A CB 1 ATOM 1009 C CG . GLU A 1 134 ? 32.481 122.728 5.435 1.00 62.85 ? 127 GLU A CG 1 ATOM 1010 C CD . GLU A 1 134 ? 33.564 123.412 4.614 1.00 86.58 ? 127 GLU A CD 1 ATOM 1011 O OE1 . GLU A 1 134 ? 34.702 123.564 5.111 1.00 77.66 ? 127 GLU A OE1 1 ATOM 1012 O OE2 . GLU A 1 134 ? 33.261 123.829 3.473 1.00 86.62 ? 127 GLU A OE2 1 ATOM 1013 N N . GLN A 1 135 ? 34.589 119.721 8.469 1.00 57.05 ? 128 GLN A N 1 ATOM 1014 C CA . GLN A 1 135 ? 34.768 118.431 9.152 1.00 56.81 ? 128 GLN A CA 1 ATOM 1015 C C . GLN A 1 135 ? 35.475 118.575 10.508 1.00 58.08 ? 128 GLN A C 1 ATOM 1016 O O . GLN A 1 135 ? 35.834 117.569 11.128 1.00 57.28 ? 128 GLN A O 1 ATOM 1017 C CB . GLN A 1 135 ? 35.492 117.408 8.239 1.00 58.76 ? 128 GLN A CB 1 ATOM 1018 C CG . GLN A 1 135 ? 34.751 117.056 6.941 1.00 77.53 ? 128 GLN A CG 1 ATOM 1019 C CD . GLN A 1 135 ? 33.524 116.178 7.126 1.00 101.21 ? 128 GLN A CD 1 ATOM 1020 O OE1 . GLN A 1 135 ? 33.622 114.975 7.406 1.00 98.67 ? 128 GLN A OE1 1 ATOM 1021 N NE2 . GLN A 1 135 ? 32.340 116.749 6.911 1.00 89.72 ? 128 GLN A NE2 1 ATOM 1022 N N . ALA A 1 136 ? 35.656 119.828 10.970 1.00 53.03 ? 129 ALA A N 1 ATOM 1023 C CA . ALA A 1 136 ? 36.326 120.123 12.232 1.00 51.99 ? 129 ALA A CA 1 ATOM 1024 C C . ALA A 1 136 ? 35.356 120.080 13.411 1.00 56.08 ? 129 ALA A C 1 ATOM 1025 O O . ALA A 1 136 ? 34.328 120.758 13.407 1.00 56.52 ? 129 ALA A O 1 ATOM 1026 C CB . ALA A 1 136 ? 37.031 121.464 12.154 1.00 52.18 ? 129 ALA A CB 1 ATOM 1027 N N . ILE A 1 137 ? 35.688 119.268 14.418 1.00 51.88 ? 130 ILE A N 1 ATOM 1028 C CA . ILE A 1 137 ? 34.904 119.096 15.634 1.00 51.67 ? 130 ILE A CA 1 ATOM 1029 C C . ILE A 1 137 ? 35.040 120.358 16.456 1.00 58.22 ? 130 ILE A C 1 ATOM 1030 O O . ILE A 1 137 ? 36.162 120.869 16.617 1.00 60.27 ? 130 ILE A O 1 ATOM 1031 C CB . ILE A 1 137 ? 35.346 117.810 16.381 1.00 54.90 ? 130 ILE A CB 1 ATOM 1032 C CG1 . ILE A 1 137 ? 35.324 116.548 15.447 1.00 54.69 ? 130 ILE A CG1 1 ATOM 1033 C CG2 . ILE A 1 137 ? 34.579 117.571 17.699 1.00 56.23 ? 130 ILE A CG2 1 ATOM 1034 C CD1 . ILE A 1 137 ? 33.989 116.063 14.901 1.00 55.90 ? 130 ILE A CD1 1 ATOM 1035 N N . GLY A 1 138 ? 33.894 120.885 16.907 1.00 53.92 ? 131 GLY A N 1 ATOM 1036 C CA . GLY A 1 138 ? 33.793 122.144 17.645 1.00 53.22 ? 131 GLY A CA 1 ATOM 1037 C C . GLY A 1 138 ? 33.968 123.342 16.731 1.00 59.61 ? 131 GLY A C 1 ATOM 1038 O O . GLY A 1 138 ? 34.091 124.474 17.207 1.00 59.70 ? 131 GLY A O 1 ATOM 1039 N N . ARG A 1 139 ? 33.990 123.090 15.396 1.00 58.25 ? 132 ARG A N 1 ATOM 1040 C CA . ARG A 1 139 ? 34.175 124.063 14.313 1.00 59.80 ? 132 ARG A CA 1 ATOM 1041 C C . ARG A 1 139 ? 35.404 124.948 14.556 1.00 63.83 ? 132 ARG A C 1 ATOM 1042 O O . ARG A 1 139 ? 35.373 126.168 14.373 1.00 65.19 ? 132 ARG A O 1 ATOM 1043 C CB . ARG A 1 139 ? 32.882 124.871 14.026 1.00 65.90 ? 132 ARG A CB 1 ATOM 1044 C CG . ARG A 1 139 ? 32.546 124.999 12.520 1.00 86.95 ? 132 ARG A CG 1 ATOM 1045 C CD . ARG A 1 139 ? 32.223 123.658 11.853 1.00 102.78 ? 132 ARG A CD 1 ATOM 1046 N NE . ARG A 1 139 ? 31.377 123.791 10.661 1.00 115.64 ? 132 ARG A NE 1 ATOM 1047 C CZ . ARG A 1 139 ? 30.711 122.785 10.094 1.00 130.24 ? 132 ARG A CZ 1 ATOM 1048 N NH1 . ARG A 1 139 ? 30.783 121.559 10.604 1.00 116.83 ? 132 ARG A NH1 1 ATOM 1049 N NH2 . ARG A 1 139 ? 29.964 122.997 9.018 1.00 113.86 ? 132 ARG A NH2 1 ATOM 1050 N N . VAL A 1 140 ? 36.500 124.296 14.972 1.00 57.57 ? 133 VAL A N 1 ATOM 1051 C CA . VAL A 1 140 ? 37.789 124.916 15.243 1.00 55.07 ? 133 VAL A CA 1 ATOM 1052 C C . VAL A 1 140 ? 38.474 125.133 13.901 1.00 55.04 ? 133 VAL A C 1 ATOM 1053 O O . VAL A 1 140 ? 38.491 124.218 13.068 1.00 55.16 ? 133 VAL A O 1 ATOM 1054 C CB . VAL A 1 140 ? 38.626 124.007 16.179 1.00 58.45 ? 133 VAL A CB 1 ATOM 1055 C CG1 . VAL A 1 140 ? 39.965 124.640 16.483 1.00 57.81 ? 133 VAL A CG1 1 ATOM 1056 C CG2 . VAL A 1 140 ? 37.879 123.693 17.474 1.00 58.04 ? 133 VAL A CG2 1 ATOM 1057 N N . THR A 1 141 ? 39.031 126.330 13.684 1.00 49.16 ? 134 THR A N 1 ATOM 1058 C CA . THR A 1 141 ? 39.734 126.650 12.437 1.00 48.17 ? 134 THR A CA 1 ATOM 1059 C C . THR A 1 141 ? 40.899 125.678 12.173 1.00 53.81 ? 134 THR A C 1 ATOM 1060 O O . THR A 1 141 ? 41.756 125.539 13.037 1.00 55.53 ? 134 THR A O 1 ATOM 1061 C CB . THR A 1 141 ? 40.210 128.108 12.441 1.00 43.29 ? 134 THR A CB 1 ATOM 1062 O OG1 . THR A 1 141 ? 39.083 128.952 12.697 1.00 43.81 ? 134 THR A OG1 1 ATOM 1063 C CG2 . THR A 1 141 ? 40.892 128.506 11.122 1.00 35.32 ? 134 THR A CG2 1 ATOM 1064 N N . PRO A 1 142 ? 40.963 124.988 11.015 1.00 50.30 ? 135 PRO A N 1 ATOM 1065 C CA . PRO A 1 142 ? 42.107 124.100 10.764 1.00 49.37 ? 135 PRO A CA 1 ATOM 1066 C C . PRO A 1 142 ? 43.385 124.897 10.543 1.00 52.74 ? 135 PRO A C 1 ATOM 1067 O O . PRO A 1 142 ? 43.326 126.074 10.165 1.00 52.74 ? 135 PRO A O 1 ATOM 1068 C CB . PRO A 1 142 ? 41.686 123.297 9.525 1.00 50.83 ? 135 PRO A CB 1 ATOM 1069 C CG . PRO A 1 142 ? 40.232 123.580 9.323 1.00 55.02 ? 135 PRO A CG 1 ATOM 1070 C CD . PRO A 1 142 ? 40.031 124.971 9.869 1.00 51.75 ? 135 PRO A CD 1 ATOM 1071 N N . ILE A 1 143 ? 44.540 124.278 10.850 1.00 48.46 ? 136 ILE A N 1 ATOM 1072 C CA . ILE A 1 143 ? 45.868 124.910 10.770 1.00 46.60 ? 136 ILE A CA 1 ATOM 1073 C C . ILE A 1 143 ? 46.171 125.499 9.369 1.00 50.90 ? 136 ILE A C 1 ATOM 1074 O O . ILE A 1 143 ? 46.709 126.600 9.322 1.00 51.47 ? 136 ILE A O 1 ATOM 1075 C CB . ILE A 1 143 ? 46.982 123.966 11.291 1.00 47.66 ? 136 ILE A CB 1 ATOM 1076 C CG1 . ILE A 1 143 ? 48.297 124.726 11.560 1.00 46.48 ? 136 ILE A CG1 1 ATOM 1077 C CG2 . ILE A 1 143 ? 47.183 122.741 10.396 1.00 46.39 ? 136 ILE A CG2 1 ATOM 1078 C CD1 . ILE A 1 143 ? 49.178 124.075 12.689 1.00 42.69 ? 136 ILE A CD1 1 ATOM 1079 N N . PHE A 1 144 ? 45.799 124.806 8.253 1.00 46.66 ? 137 PHE A N 1 ATOM 1080 C CA . PHE A 1 144 ? 46.064 125.328 6.901 1.00 45.76 ? 137 PHE A CA 1 ATOM 1081 C C . PHE A 1 144 ? 45.288 126.613 6.652 1.00 51.58 ? 137 PHE A C 1 ATOM 1082 O O . PHE A 1 144 ? 45.862 127.564 6.114 1.00 50.03 ? 137 PHE A O 1 ATOM 1083 C CB . PHE A 1 144 ? 45.866 124.291 5.780 1.00 46.70 ? 137 PHE A CB 1 ATOM 1084 C CG . PHE A 1 144 ? 46.492 124.696 4.458 1.00 48.56 ? 137 PHE A CG 1 ATOM 1085 C CD1 . PHE A 1 144 ? 47.879 124.771 4.313 1.00 51.15 ? 137 PHE A CD1 1 ATOM 1086 C CD2 . PHE A 1 144 ? 45.698 124.970 3.345 1.00 51.40 ? 137 PHE A CD2 1 ATOM 1087 C CE1 . PHE A 1 144 ? 48.452 125.154 3.086 1.00 51.94 ? 137 PHE A CE1 1 ATOM 1088 C CE2 . PHE A 1 144 ? 46.274 125.370 2.126 1.00 53.96 ? 137 PHE A CE2 1 ATOM 1089 C CZ . PHE A 1 144 ? 47.642 125.468 2.008 1.00 51.40 ? 137 PHE A CZ 1 ATOM 1090 N N . ASP A 1 145 ? 44.020 126.678 7.136 1.00 49.99 ? 138 ASP A N 1 ATOM 1091 C CA . ASP A 1 145 ? 43.171 127.881 7.037 1.00 50.39 ? 138 ASP A CA 1 ATOM 1092 C C . ASP A 1 145 ? 43.842 129.050 7.765 1.00 55.26 ? 138 ASP A C 1 ATOM 1093 O O . ASP A 1 145 ? 43.931 130.136 7.199 1.00 57.33 ? 138 ASP A O 1 ATOM 1094 C CB . ASP A 1 145 ? 41.757 127.613 7.567 1.00 52.67 ? 138 ASP A CB 1 ATOM 1095 C CG . ASP A 1 145 ? 40.967 126.594 6.753 1.00 71.27 ? 138 ASP A CG 1 ATOM 1096 O OD1 . ASP A 1 145 ? 41.544 125.535 6.392 1.00 73.17 ? 138 ASP A OD1 1 ATOM 1097 O OD2 . ASP A 1 145 ? 39.759 126.829 6.516 1.00 79.34 ? 138 ASP A OD2 1 ATOM 1098 N N . ASN A 1 146 ? 44.431 128.800 8.948 1.00 51.32 ? 139 ASN A N 1 ATOM 1099 C CA . ASN A 1 146 ? 45.165 129.829 9.688 1.00 51.66 ? 139 ASN A CA 1 ATOM 1100 C C . ASN A 1 146 ? 46.477 130.223 8.974 1.00 56.05 ? 139 ASN A C 1 ATOM 1101 O O . ASN A 1 146 ? 46.844 131.402 8.988 1.00 54.55 ? 139 ASN A O 1 ATOM 1102 C CB . ASN A 1 146 ? 45.386 129.435 11.176 1.00 52.33 ? 139 ASN A CB 1 ATOM 1103 C CG . ASN A 1 146 ? 44.171 129.577 12.076 1.00 55.91 ? 139 ASN A CG 1 ATOM 1104 O OD1 . ASN A 1 146 ? 43.459 130.573 12.041 1.00 51.63 ? 139 ASN A OD1 1 ATOM 1105 N ND2 . ASN A 1 146 ? 43.907 128.602 12.928 1.00 40.14 ? 139 ASN A ND2 1 ATOM 1106 N N . ILE A 1 147 ? 47.155 129.257 8.319 1.00 55.09 ? 140 ILE A N 1 ATOM 1107 C CA . ILE A 1 147 ? 48.385 129.549 7.558 1.00 56.47 ? 140 ILE A CA 1 ATOM 1108 C C . ILE A 1 147 ? 48.044 130.403 6.293 1.00 65.44 ? 140 ILE A C 1 ATOM 1109 O O . ILE A 1 147 ? 48.751 131.387 6.013 1.00 65.40 ? 140 ILE A O 1 ATOM 1110 C CB . ILE A 1 147 ? 49.209 128.272 7.248 1.00 59.01 ? 140 ILE A CB 1 ATOM 1111 C CG1 . ILE A 1 147 ? 49.843 127.717 8.537 1.00 58.50 ? 140 ILE A CG1 1 ATOM 1112 C CG2 . ILE A 1 147 ? 50.276 128.535 6.171 1.00 60.37 ? 140 ILE A CG2 1 ATOM 1113 C CD1 . ILE A 1 147 ? 50.311 126.280 8.440 1.00 59.07 ? 140 ILE A CD1 1 ATOM 1114 N N . ILE A 1 148 ? 46.936 130.035 5.566 1.00 63.29 ? 141 ILE A N 1 ATOM 1115 C CA . ILE A 1 148 ? 46.435 130.772 4.398 1.00 63.60 ? 141 ILE A CA 1 ATOM 1116 C C . ILE A 1 148 ? 46.209 132.228 4.855 1.00 66.24 ? 141 ILE A C 1 ATOM 1117 O O . ILE A 1 148 ? 46.755 133.137 4.228 1.00 66.87 ? 141 ILE A O 1 ATOM 1118 C CB . ILE A 1 148 ? 45.115 130.182 3.800 1.00 67.23 ? 141 ILE A CB 1 ATOM 1119 C CG1 . ILE A 1 148 ? 45.249 128.737 3.297 1.00 68.32 ? 141 ILE A CG1 1 ATOM 1120 C CG2 . ILE A 1 148 ? 44.554 131.078 2.692 1.00 67.29 ? 141 ILE A CG2 1 ATOM 1121 C CD1 . ILE A 1 148 ? 43.798 127.959 3.200 1.00 77.09 ? 141 ILE A CD1 1 ATOM 1122 N N . SER A 1 149 ? 45.449 132.428 5.973 1.00 59.30 ? 142 SER A N 1 ATOM 1123 C CA . SER A 1 149 ? 45.137 133.749 6.531 1.00 58.95 ? 142 SER A CA 1 ATOM 1124 C C . SER A 1 149 ? 46.336 134.683 6.673 1.00 63.47 ? 142 SER A C 1 ATOM 1125 O O . SER A 1 149 ? 46.174 135.891 6.552 1.00 64.57 ? 142 SER A O 1 ATOM 1126 C CB . SER A 1 149 ? 44.417 133.629 7.867 1.00 61.56 ? 142 SER A CB 1 ATOM 1127 O OG . SER A 1 149 ? 43.122 133.089 7.681 1.00 71.07 ? 142 SER A OG 1 ATOM 1128 N N . GLN A 1 150 ? 47.531 134.132 6.897 1.00 59.85 ? 143 GLN A N 1 ATOM 1129 C CA . GLN A 1 150 ? 48.756 134.916 7.055 1.00 59.36 ? 143 GLN A CA 1 ATOM 1130 C C . GLN A 1 150 ? 49.246 135.562 5.754 1.00 63.30 ? 143 GLN A C 1 ATOM 1131 O O . GLN A 1 150 ? 50.101 136.440 5.817 1.00 63.27 ? 143 GLN A O 1 ATOM 1132 C CB . GLN A 1 150 ? 49.870 134.089 7.711 1.00 60.49 ? 143 GLN A CB 1 ATOM 1133 C CG . GLN A 1 150 ? 49.509 133.535 9.093 1.00 69.73 ? 143 GLN A CG 1 ATOM 1134 C CD . GLN A 1 150 ? 50.681 132.865 9.765 1.00 83.75 ? 143 GLN A CD 1 ATOM 1135 O OE1 . GLN A 1 150 ? 51.662 132.454 9.117 1.00 76.81 ? 143 GLN A OE1 1 ATOM 1136 N NE2 . GLN A 1 150 ? 50.607 132.774 11.091 1.00 74.44 ? 143 GLN A NE2 1 ATOM 1137 N N . GLY A 1 151 ? 48.712 135.117 4.611 1.00 59.64 ? 144 GLY A N 1 ATOM 1138 C CA . GLY A 1 151 ? 49.025 135.627 3.278 1.00 59.76 ? 144 GLY A CA 1 ATOM 1139 C C . GLY A 1 151 ? 50.497 135.619 2.937 1.00 64.27 ? 144 GLY A C 1 ATOM 1140 O O . GLY A 1 151 ? 51.027 136.573 2.355 1.00 64.36 ? 144 GLY A O 1 ATOM 1141 N N . VAL A 1 152 ? 51.157 134.529 3.312 1.00 60.48 ? 145 VAL A N 1 ATOM 1142 C CA . VAL A 1 152 ? 52.583 134.327 3.143 1.00 59.76 ? 145 VAL A CA 1 ATOM 1143 C C . VAL A 1 152 ? 52.908 133.230 2.061 1.00 63.40 ? 145 VAL A C 1 ATOM 1144 O O . VAL A 1 152 ? 53.980 133.269 1.459 1.00 62.90 ? 145 VAL A O 1 ATOM 1145 C CB . VAL A 1 152 ? 53.164 134.060 4.568 1.00 63.32 ? 145 VAL A CB 1 ATOM 1146 C CG1 . VAL A 1 152 ? 53.494 132.595 4.836 1.00 62.43 ? 145 VAL A CG1 1 ATOM 1147 C CG2 . VAL A 1 152 ? 54.346 134.960 4.866 1.00 63.29 ? 145 VAL A CG2 1 ATOM 1148 N N . LEU A 1 153 ? 51.959 132.307 1.790 1.00 60.16 ? 146 LEU A N 1 ATOM 1149 C CA . LEU A 1 153 ? 52.144 131.210 0.836 1.00 60.14 ? 146 LEU A CA 1 ATOM 1150 C C . LEU A 1 153 ? 52.039 131.624 -0.628 1.00 64.44 ? 146 LEU A C 1 ATOM 1151 O O . LEU A 1 153 ? 51.132 132.374 -0.986 1.00 64.95 ? 146 LEU A O 1 ATOM 1152 C CB . LEU A 1 153 ? 51.160 130.057 1.112 1.00 60.42 ? 146 LEU A CB 1 ATOM 1153 C CG . LEU A 1 153 ? 51.300 129.269 2.425 1.00 64.97 ? 146 LEU A CG 1 ATOM 1154 C CD1 . LEU A 1 153 ? 50.285 128.148 2.454 1.00 64.75 ? 146 LEU A CD1 1 ATOM 1155 C CD2 . LEU A 1 153 ? 52.732 128.705 2.612 1.00 65.92 ? 146 LEU A CD2 1 ATOM 1156 N N . LYS A 1 154 ? 52.926 131.079 -1.486 1.00 60.25 ? 147 LYS A N 1 ATOM 1157 C CA . LYS A 1 154 ? 52.957 131.353 -2.928 1.00 59.44 ? 147 LYS A CA 1 ATOM 1158 C C . LYS A 1 154 ? 51.638 130.938 -3.596 1.00 63.16 ? 147 LYS A C 1 ATOM 1159 O O . LYS A 1 154 ? 51.110 131.679 -4.421 1.00 63.15 ? 147 LYS A O 1 ATOM 1160 C CB . LYS A 1 154 ? 54.188 130.697 -3.572 1.00 61.68 ? 147 LYS A CB 1 ATOM 1161 C CG . LYS A 1 154 ? 54.473 131.166 -4.979 1.00 77.78 ? 147 LYS A CG 1 ATOM 1162 C CD . LYS A 1 154 ? 55.923 131.516 -5.187 1.00 91.82 ? 147 LYS A CD 1 ATOM 1163 C CE . LYS A 1 154 ? 56.160 132.159 -6.542 1.00 102.81 ? 147 LYS A CE 1 ATOM 1164 N NZ . LYS A 1 154 ? 55.575 133.531 -6.631 1.00 113.95 ? 147 LYS A NZ 1 ATOM 1165 N N . GLU A 1 155 ? 51.088 129.784 -3.186 1.00 60.34 ? 148 GLU A N 1 ATOM 1166 C CA . GLU A 1 155 ? 49.815 129.222 -3.645 1.00 60.03 ? 148 GLU A CA 1 ATOM 1167 C C . GLU A 1 155 ? 49.077 128.621 -2.466 1.00 64.43 ? 148 GLU A C 1 ATOM 1168 O O . GLU A 1 155 ? 49.688 128.144 -1.511 1.00 63.43 ? 148 GLU A O 1 ATOM 1169 C CB . GLU A 1 155 ? 50.005 128.133 -4.700 1.00 61.44 ? 148 GLU A CB 1 ATOM 1170 C CG . GLU A 1 155 ? 50.503 128.580 -6.052 1.00 75.46 ? 148 GLU A CG 1 ATOM 1171 C CD . GLU A 1 155 ? 51.414 127.479 -6.563 1.00 106.96 ? 148 GLU A CD 1 ATOM 1172 O OE1 . GLU A 1 155 ? 52.620 127.489 -6.222 1.00 108.38 ? 148 GLU A OE1 1 ATOM 1173 O OE2 . GLU A 1 155 ? 50.891 126.532 -7.193 1.00 103.67 ? 148 GLU A OE2 1 ATOM 1174 N N . ASP A 1 156 ? 47.755 128.611 -2.554 1.00 61.83 ? 149 ASP A N 1 ATOM 1175 C CA . ASP A 1 156 ? 46.861 128.082 -1.534 1.00 61.47 ? 149 ASP A CA 1 ATOM 1176 C C . ASP A 1 156 ? 46.684 126.551 -1.797 1.00 63.51 ? 149 ASP A C 1 ATOM 1177 O O . ASP A 1 156 ? 45.578 126.041 -2.058 1.00 62.37 ? 149 ASP A O 1 ATOM 1178 C CB . ASP A 1 156 ? 45.560 128.909 -1.585 1.00 64.35 ? 149 ASP A CB 1 ATOM 1179 C CG . ASP A 1 156 ? 44.439 128.555 -0.638 1.00 85.17 ? 149 ASP A CG 1 ATOM 1180 O OD1 . ASP A 1 156 ? 44.640 127.669 0.211 1.00 88.02 ? 149 ASP A OD1 1 ATOM 1181 O OD2 . ASP A 1 156 ? 43.341 129.152 -0.770 1.00 92.98 ? 149 ASP A OD2 1 ATOM 1182 N N . VAL A 1 157 ? 47.836 125.831 -1.780 1.00 57.83 ? 150 VAL A N 1 ATOM 1183 C CA . VAL A 1 157 ? 47.950 124.383 -2.034 1.00 55.46 ? 150 VAL A CA 1 ATOM 1184 C C . VAL A 1 157 ? 48.979 123.743 -1.088 1.00 55.37 ? 150 VAL A C 1 ATOM 1185 O O . VAL A 1 157 ? 49.863 124.437 -0.585 1.00 55.60 ? 150 VAL A O 1 ATOM 1186 C CB . VAL A 1 157 ? 48.267 124.006 -3.540 1.00 58.16 ? 150 VAL A CB 1 ATOM 1187 C CG1 . VAL A 1 157 ? 47.434 124.790 -4.536 1.00 57.42 ? 150 VAL A CG1 1 ATOM 1188 C CG2 . VAL A 1 157 ? 49.737 124.152 -3.871 1.00 57.82 ? 150 VAL A CG2 1 ATOM 1189 N N . PHE A 1 158 ? 48.898 122.409 -0.905 1.00 47.09 ? 151 PHE A N 1 ATOM 1190 C CA . PHE A 1 158 ? 49.894 121.629 -0.171 1.00 43.75 ? 151 PHE A CA 1 ATOM 1191 C C . PHE A 1 158 ? 50.084 120.274 -0.853 1.00 48.28 ? 151 PHE A C 1 ATOM 1192 O O . PHE A 1 158 ? 49.126 119.727 -1.444 1.00 47.58 ? 151 PHE A O 1 ATOM 1193 C CB . PHE A 1 158 ? 49.645 121.531 1.348 1.00 43.49 ? 151 PHE A CB 1 ATOM 1194 C CG . PHE A 1 158 ? 48.333 120.916 1.748 1.00 43.04 ? 151 PHE A CG 1 ATOM 1195 C CD1 . PHE A 1 158 ? 48.208 119.543 1.897 1.00 45.60 ? 151 PHE A CD1 1 ATOM 1196 C CD2 . PHE A 1 158 ? 47.219 121.713 1.986 1.00 43.82 ? 151 PHE A CD2 1 ATOM 1197 C CE1 . PHE A 1 158 ? 46.977 118.973 2.236 1.00 47.82 ? 151 PHE A CE1 1 ATOM 1198 C CE2 . PHE A 1 158 ? 45.995 121.149 2.348 1.00 46.31 ? 151 PHE A CE2 1 ATOM 1199 C CZ . PHE A 1 158 ? 45.877 119.787 2.468 1.00 45.75 ? 151 PHE A CZ 1 ATOM 1200 N N . SER A 1 159 ? 51.335 119.741 -0.787 1.00 43.51 ? 152 SER A N 1 ATOM 1201 C CA . SER A 1 159 ? 51.693 118.512 -1.472 1.00 42.38 ? 152 SER A CA 1 ATOM 1202 C C . SER A 1 159 ? 52.314 117.462 -0.598 1.00 47.88 ? 152 SER A C 1 ATOM 1203 O O . SER A 1 159 ? 53.117 117.779 0.277 1.00 50.86 ? 152 SER A O 1 ATOM 1204 C CB . SER A 1 159 ? 52.644 118.817 -2.619 1.00 45.92 ? 152 SER A CB 1 ATOM 1205 O OG . SER A 1 159 ? 52.049 119.636 -3.606 1.00 58.73 ? 152 SER A OG 1 ATOM 1206 N N . PHE A 1 160 ? 52.034 116.191 -0.924 1.00 42.51 ? 153 PHE A N 1 ATOM 1207 C CA . PHE A 1 160 ? 52.547 115.025 -0.233 1.00 41.15 ? 153 PHE A CA 1 ATOM 1208 C C . PHE A 1 160 ? 53.350 114.131 -1.119 1.00 44.69 ? 153 PHE A C 1 ATOM 1209 O O . PHE A 1 160 ? 52.921 113.768 -2.229 1.00 42.17 ? 153 PHE A O 1 ATOM 1210 C CB . PHE A 1 160 ? 51.416 114.194 0.404 1.00 42.26 ? 153 PHE A CB 1 ATOM 1211 C CG . PHE A 1 160 ? 50.887 114.759 1.703 1.00 43.43 ? 153 PHE A CG 1 ATOM 1212 C CD1 . PHE A 1 160 ? 50.122 115.924 1.716 1.00 43.75 ? 153 PHE A CD1 1 ATOM 1213 C CD2 . PHE A 1 160 ? 51.131 114.110 2.917 1.00 44.82 ? 153 PHE A CD2 1 ATOM 1214 C CE1 . PHE A 1 160 ? 49.639 116.442 2.919 1.00 43.83 ? 153 PHE A CE1 1 ATOM 1215 C CE2 . PHE A 1 160 ? 50.622 114.623 4.124 1.00 46.35 ? 153 PHE A CE2 1 ATOM 1216 C CZ . PHE A 1 160 ? 49.882 115.780 4.117 1.00 43.56 ? 153 PHE A CZ 1 ATOM 1217 N N . TYR A 1 161 ? 54.526 113.752 -0.582 1.00 41.95 ? 154 TYR A N 1 ATOM 1218 C CA . TYR A 1 161 ? 55.450 112.769 -1.112 1.00 41.05 ? 154 TYR A CA 1 ATOM 1219 C C . TYR A 1 161 ? 55.675 111.758 0.024 1.00 43.84 ? 154 TYR A C 1 ATOM 1220 O O . TYR A 1 161 ? 56.039 112.158 1.131 1.00 43.74 ? 154 TYR A O 1 ATOM 1221 C CB . TYR A 1 161 ? 56.788 113.412 -1.539 1.00 41.85 ? 154 TYR A CB 1 ATOM 1222 C CG . TYR A 1 161 ? 57.877 112.393 -1.801 1.00 40.71 ? 154 TYR A CG 1 ATOM 1223 C CD1 . TYR A 1 161 ? 57.783 111.503 -2.873 1.00 42.26 ? 154 TYR A CD1 1 ATOM 1224 C CD2 . TYR A 1 161 ? 58.959 112.263 -0.934 1.00 40.65 ? 154 TYR A CD2 1 ATOM 1225 C CE1 . TYR A 1 161 ? 58.758 110.532 -3.094 1.00 41.66 ? 154 TYR A CE1 1 ATOM 1226 C CE2 . TYR A 1 161 ? 59.935 111.287 -1.140 1.00 41.67 ? 154 TYR A CE2 1 ATOM 1227 C CZ . TYR A 1 161 ? 59.830 110.426 -2.224 1.00 46.09 ? 154 TYR A CZ 1 ATOM 1228 O OH . TYR A 1 161 ? 60.761 109.444 -2.432 1.00 46.31 ? 154 TYR A OH 1 ATOM 1229 N N . TYR A 1 162 ? 55.426 110.468 -0.244 1.00 39.47 ? 155 TYR A N 1 ATOM 1230 C CA . TYR A 1 162 ? 55.657 109.361 0.693 1.00 39.45 ? 155 TYR A CA 1 ATOM 1231 C C . TYR A 1 162 ? 56.595 108.409 -0.019 1.00 45.34 ? 155 TYR A C 1 ATOM 1232 O O . TYR A 1 162 ? 56.248 107.909 -1.090 1.00 46.98 ? 155 TYR A O 1 ATOM 1233 C CB . TYR A 1 162 ? 54.350 108.610 1.013 1.00 39.95 ? 155 TYR A CB 1 ATOM 1234 C CG . TYR A 1 162 ? 53.429 109.225 2.037 1.00 39.28 ? 155 TYR A CG 1 ATOM 1235 C CD1 . TYR A 1 162 ? 53.781 110.388 2.716 1.00 40.90 ? 155 TYR A CD1 1 ATOM 1236 C CD2 . TYR A 1 162 ? 52.223 108.618 2.364 1.00 39.37 ? 155 TYR A CD2 1 ATOM 1237 C CE1 . TYR A 1 162 ? 52.940 110.944 3.674 1.00 41.34 ? 155 TYR A CE1 1 ATOM 1238 C CE2 . TYR A 1 162 ? 51.373 109.167 3.317 1.00 39.86 ? 155 TYR A CE2 1 ATOM 1239 C CZ . TYR A 1 162 ? 51.742 110.322 3.979 1.00 43.35 ? 155 TYR A CZ 1 ATOM 1240 O OH . TYR A 1 162 ? 50.925 110.841 4.939 1.00 41.91 ? 155 TYR A OH 1 ATOM 1241 N N . ASN A 1 163 ? 57.784 108.192 0.530 1.00 42.79 ? 156 ASN A N 1 ATOM 1242 C CA . ASN A 1 163 ? 58.781 107.305 -0.058 1.00 44.40 ? 156 ASN A CA 1 ATOM 1243 C C . ASN A 1 163 ? 58.567 105.835 0.375 1.00 53.20 ? 156 ASN A C 1 ATOM 1244 O O . ASN A 1 163 ? 57.790 105.558 1.296 1.00 54.28 ? 156 ASN A O 1 ATOM 1245 C CB . ASN A 1 163 ? 60.181 107.800 0.387 1.00 46.95 ? 156 ASN A CB 1 ATOM 1246 C CG . ASN A 1 163 ? 61.388 107.249 -0.360 1.00 55.85 ? 156 ASN A CG 1 ATOM 1247 O OD1 . ASN A 1 163 ? 61.306 106.467 -1.301 1.00 45.19 ? 156 ASN A OD1 1 ATOM 1248 N ND2 . ASN A 1 163 ? 62.554 107.670 0.036 1.00 50.34 ? 156 ASN A ND2 1 ATOM 1249 N N . ARG A 1 164 ? 59.252 104.903 -0.300 1.00 52.95 ? 157 ARG A N 1 ATOM 1250 C CA . ARG A 1 164 ? 59.334 103.475 0.034 1.00 55.38 ? 157 ARG A CA 1 ATOM 1251 C C . ARG A 1 164 ? 60.441 103.363 1.102 1.00 65.50 ? 157 ARG A C 1 ATOM 1252 O O . ARG A 1 164 ? 61.452 104.063 1.011 1.00 65.60 ? 157 ARG A O 1 ATOM 1253 C CB . ARG A 1 164 ? 59.717 102.664 -1.215 1.00 57.12 ? 157 ARG A CB 1 ATOM 1254 C CG . ARG A 1 164 ? 58.543 102.445 -2.167 1.00 72.79 ? 157 ARG A CG 1 ATOM 1255 C CD . ARG A 1 164 ? 58.687 103.130 -3.523 1.00 75.61 ? 157 ARG A CD 1 ATOM 1256 N NE . ARG A 1 164 ? 57.457 102.966 -4.304 1.00 82.05 ? 157 ARG A NE 1 ATOM 1257 C CZ . ARG A 1 164 ? 57.207 103.533 -5.478 1.00 97.66 ? 157 ARG A CZ 1 ATOM 1258 N NH1 . ARG A 1 164 ? 58.104 104.335 -6.040 1.00 84.71 ? 157 ARG A NH1 1 ATOM 1259 N NH2 . ARG A 1 164 ? 56.054 103.313 -6.094 1.00 94.04 ? 157 ARG A NH2 1 ATOM 1260 N N . ASP A 1 165 ? 60.242 102.531 2.128 1.00 67.67 ? 158 ASP A N 1 ATOM 1261 C CA . ASP A 1 165 ? 61.147 102.385 3.290 1.00 69.36 ? 158 ASP A CA 1 ATOM 1262 C C . ASP A 1 165 ? 62.621 102.042 2.966 1.00 77.93 ? 158 ASP A C 1 ATOM 1263 O O . ASP A 1 165 ? 62.911 101.478 1.905 1.00 79.24 ? 158 ASP A O 1 ATOM 1264 C CB . ASP A 1 165 ? 60.558 101.347 4.267 1.00 70.94 ? 158 ASP A CB 1 ATOM 1265 C CG . ASP A 1 165 ? 60.964 101.464 5.729 1.00 76.74 ? 158 ASP A CG 1 ATOM 1266 O OD1 . ASP A 1 165 ? 61.628 102.471 6.095 1.00 76.47 ? 158 ASP A OD1 1 ATOM 1267 O OD2 . ASP A 1 165 ? 60.594 100.569 6.514 1.00 81.24 ? 158 ASP A OD2 1 ATOM 1268 N N . SER A 1 166 ? 63.543 102.393 3.908 1.00 75.68 ? 159 SER A N 1 ATOM 1269 C CA . SER A 1 166 ? 64.994 102.133 3.859 1.00 105.09 ? 159 SER A CA 1 ATOM 1270 C C . SER A 1 166 ? 65.380 101.088 4.904 1.00 133.84 ? 159 SER A C 1 ATOM 1271 O O . SER A 1 166 ? 65.626 99.933 4.565 1.00 100.31 ? 159 SER A O 1 ATOM 1272 C CB . SER A 1 166 ? 65.786 103.411 4.119 1.00 108.19 ? 159 SER A CB 1 ATOM 1273 N N . GLN A 1 170 C 68.858 105.998 5.828 1.00 78.39 ? 160 GLN A N 1 ATOM 1274 C CA . GLN A 1 170 C 69.717 107.088 5.347 1.00 78.56 ? 160 GLN A CA 1 ATOM 1275 C C . GLN A 1 170 C 69.010 108.006 4.309 1.00 81.71 ? 160 GLN A C 1 ATOM 1276 O O . GLN A 1 170 C 69.541 109.064 3.936 1.00 81.08 ? 160 GLN A O 1 ATOM 1277 C CB . GLN A 1 170 C 71.032 106.523 4.768 1.00 80.10 ? 160 GLN A CB 1 ATOM 1278 N N . SER A 1 171 D 67.812 107.572 3.847 1.00 76.35 ? 160 SER A N 1 ATOM 1279 C CA . SER A 1 171 D 66.952 108.238 2.863 1.00 74.13 ? 160 SER A CA 1 ATOM 1280 C C . SER A 1 171 D 65.823 109.091 3.501 1.00 73.05 ? 160 SER A C 1 ATOM 1281 O O . SER A 1 171 D 65.541 108.986 4.698 1.00 73.28 ? 160 SER A O 1 ATOM 1282 C CB . SER A 1 171 D 66.347 107.198 1.915 1.00 78.75 ? 160 SER A CB 1 ATOM 1283 O OG . SER A 1 171 D 65.438 106.299 2.537 1.00 85.92 ? 160 SER A OG 1 ATOM 1284 N N . LEU A 1 172 ? 65.180 109.932 2.679 1.00 64.16 ? 161 LEU A N 1 ATOM 1285 C CA . LEU A 1 172 ? 64.067 110.792 3.069 1.00 60.04 ? 161 LEU A CA 1 ATOM 1286 C C . LEU A 1 172 ? 62.798 109.932 3.216 1.00 56.42 ? 161 LEU A C 1 ATOM 1287 O O . LEU A 1 172 ? 62.452 109.206 2.291 1.00 54.92 ? 161 LEU A O 1 ATOM 1288 C CB . LEU A 1 172 ? 63.889 111.840 1.954 1.00 59.55 ? 161 LEU A CB 1 ATOM 1289 C CG . LEU A 1 172 ? 62.806 112.880 2.131 1.00 63.62 ? 161 LEU A CG 1 ATOM 1290 C CD1 . LEU A 1 172 ? 63.260 113.979 3.066 1.00 63.98 ? 161 LEU A CD1 1 ATOM 1291 C CD2 . LEU A 1 172 ? 62.413 113.451 0.793 1.00 63.36 ? 161 LEU A CD2 1 ATOM 1292 N N . GLY A 1 173 ? 62.117 110.022 4.355 1.00 49.37 ? 162 GLY A N 1 ATOM 1293 C CA . GLY A 1 173 ? 60.882 109.268 4.577 1.00 47.36 ? 162 GLY A CA 1 ATOM 1294 C C . GLY A 1 173 ? 59.704 109.791 3.760 1.00 47.66 ? 162 GLY A C 1 ATOM 1295 O O . GLY A 1 173 ? 58.833 109.031 3.310 1.00 47.54 ? 162 GLY A O 1 ATOM 1296 N N . GLY A 1 174 ? 59.685 111.095 3.569 1.00 40.52 ? 163 GLY A N 1 ATOM 1297 C CA . GLY A 1 174 ? 58.644 111.770 2.824 1.00 40.13 ? 163 GLY A CA 1 ATOM 1298 C C . GLY A 1 174 ? 58.787 113.260 2.992 1.00 45.16 ? 163 GLY A C 1 ATOM 1299 O O . GLY A 1 174 ? 59.732 113.735 3.636 1.00 45.13 ? 163 GLY A O 1 ATOM 1300 N N . GLN A 1 175 ? 57.851 114.008 2.416 1.00 41.86 ? 164 GLN A N 1 ATOM 1301 C CA . GLN A 1 175 ? 57.871 115.465 2.450 1.00 40.85 ? 164 GLN A CA 1 ATOM 1302 C C . GLN A 1 175 ? 56.495 116.054 2.170 1.00 45.77 ? 164 GLN A C 1 ATOM 1303 O O . GLN A 1 175 ? 55.779 115.605 1.263 1.00 46.50 ? 164 GLN A O 1 ATOM 1304 C CB . GLN A 1 175 ? 58.881 115.985 1.398 1.00 41.65 ? 164 GLN A CB 1 ATOM 1305 C CG . GLN A 1 175 ? 59.189 117.484 1.478 1.00 49.56 ? 164 GLN A CG 1 ATOM 1306 C CD . GLN A 1 175 ? 59.792 118.022 0.189 1.00 65.04 ? 164 GLN A CD 1 ATOM 1307 O OE1 . GLN A 1 175 ? 60.772 118.760 0.214 1.00 74.14 ? 164 GLN A OE1 1 ATOM 1308 N NE2 . GLN A 1 175 ? 59.226 117.694 -0.967 1.00 33.20 ? 164 GLN A NE2 1 ATOM 1309 N N . ILE A 1 176 ? 56.158 117.092 2.923 1.00 43.70 ? 165 ILE A N 1 ATOM 1310 C CA . ILE A 1 176 ? 54.960 117.925 2.739 1.00 43.71 ? 165 ILE A CA 1 ATOM 1311 C C . ILE A 1 176 ? 55.468 119.291 2.358 1.00 46.71 ? 165 ILE A C 1 ATOM 1312 O O . ILE A 1 176 ? 56.364 119.808 3.022 1.00 44.09 ? 165 ILE A O 1 ATOM 1313 C CB . ILE A 1 176 ? 54.045 118.006 3.984 1.00 46.69 ? 165 ILE A CB 1 ATOM 1314 C CG1 . ILE A 1 176 ? 53.550 116.645 4.270 1.00 49.04 ? 165 ILE A CG1 1 ATOM 1315 C CG2 . ILE A 1 176 ? 52.888 118.985 3.760 1.00 43.82 ? 165 ILE A CG2 1 ATOM 1316 C CD1 . ILE A 1 176 ? 53.341 116.519 5.489 1.00 52.21 ? 165 ILE A CD1 1 ATOM 1317 N N . VAL A 1 177 ? 54.960 119.832 1.250 1.00 45.18 ? 166 VAL A N 1 ATOM 1318 C CA . VAL A 1 177 ? 55.282 121.185 0.816 1.00 45.55 ? 166 VAL A CA 1 ATOM 1319 C C . VAL A 1 177 ? 54.008 121.975 1.054 1.00 49.26 ? 166 VAL A C 1 ATOM 1320 O O . VAL A 1 177 ? 52.943 121.558 0.591 1.00 49.67 ? 166 VAL A O 1 ATOM 1321 C CB . VAL A 1 177 ? 55.736 121.300 -0.662 1.00 50.22 ? 166 VAL A CB 1 ATOM 1322 C CG1 . VAL A 1 177 ? 56.071 122.750 -1.023 1.00 49.78 ? 166 VAL A CG1 1 ATOM 1323 C CG2 . VAL A 1 177 ? 56.919 120.398 -0.956 1.00 50.42 ? 166 VAL A CG2 1 ATOM 1324 N N . LEU A 1 178 ? 54.106 123.083 1.790 1.00 45.16 ? 167 LEU A N 1 ATOM 1325 C CA . LEU A 1 178 ? 53.007 124.007 2.041 1.00 45.82 ? 167 LEU A CA 1 ATOM 1326 C C . LEU A 1 178 ? 53.225 125.189 1.093 1.00 51.80 ? 167 LEU A C 1 ATOM 1327 O O . LEU A 1 178 ? 54.319 125.765 1.059 1.00 50.22 ? 167 LEU A O 1 ATOM 1328 C CB . LEU A 1 178 ? 52.985 124.492 3.513 1.00 45.73 ? 167 LEU A CB 1 ATOM 1329 C CG . LEU A 1 178 ? 52.806 123.448 4.618 1.00 50.39 ? 167 LEU A CG 1 ATOM 1330 C CD1 . LEU A 1 178 ? 53.135 124.026 5.972 1.00 50.19 ? 167 LEU A CD1 1 ATOM 1331 C CD2 . LEU A 1 178 ? 51.412 122.836 4.619 1.00 52.88 ? 167 LEU A CD2 1 ATOM 1332 N N . GLY A 1 179 ? 52.212 125.496 0.291 1.00 50.83 ? 168 GLY A N 1 ATOM 1333 C CA . GLY A 1 179 ? 52.281 126.594 -0.668 1.00 52.10 ? 168 GLY A CA 1 ATOM 1334 C C . GLY A 1 179 ? 52.726 126.223 -2.079 1.00 57.31 ? 168 GLY A C 1 ATOM 1335 O O . GLY A 1 179 ? 52.892 127.113 -2.918 1.00 56.81 ? 168 GLY A O 1 ATOM 1336 N N . GLY A 1 180 ? 52.928 124.925 -2.344 1.00 53.47 ? 169 GLY A N 1 ATOM 1337 C CA . GLY A 1 180 ? 53.367 124.424 -3.643 1.00 52.68 ? 169 GLY A CA 1 ATOM 1338 C C . GLY A 1 180 ? 53.595 122.933 -3.682 1.00 57.03 ? 169 GLY A C 1 ATOM 1339 O O . GLY A 1 180 ? 52.972 122.182 -2.921 1.00 57.01 ? 169 GLY A O 1 ATOM 1340 N N . SER A 1 181 ? 54.504 122.500 -4.583 1.00 54.02 ? 170 SER A N 1 ATOM 1341 C CA . SER A 1 181 ? 54.913 121.101 -4.817 1.00 52.99 ? 170 SER A CA 1 ATOM 1342 C C . SER A 1 181 ? 56.419 121.046 -5.127 1.00 54.57 ? 170 SER A C 1 ATOM 1343 O O . SER A 1 181 ? 56.992 122.058 -5.542 1.00 53.79 ? 170 SER A O 1 ATOM 1344 C CB . SER A 1 181 ? 54.127 120.492 -5.978 1.00 56.77 ? 170 SER A CB 1 ATOM 1345 O OG . SER A 1 181 ? 54.524 121.053 -7.219 1.00 68.32 ? 170 SER A OG 1 ATOM 1346 N N . ASP A 1 182 ? 57.061 119.878 -4.916 1.00 50.25 ? 171 ASP A N 1 ATOM 1347 C CA . ASP A 1 182 ? 58.484 119.713 -5.194 1.00 49.40 ? 171 ASP A CA 1 ATOM 1348 C C . ASP A 1 182 ? 58.664 118.852 -6.442 1.00 54.01 ? 171 ASP A C 1 ATOM 1349 O O . ASP A 1 182 ? 58.385 117.650 -6.406 1.00 53.54 ? 171 ASP A O 1 ATOM 1350 C CB . ASP A 1 182 ? 59.241 119.157 -3.987 1.00 50.44 ? 171 ASP A CB 1 ATOM 1351 C CG . ASP A 1 182 ? 60.750 119.064 -4.140 1.00 58.34 ? 171 ASP A CG 1 ATOM 1352 O OD1 . ASP A 1 182 ? 61.258 119.275 -5.271 1.00 57.11 ? 171 ASP A OD1 1 ATOM 1353 O OD2 . ASP A 1 182 ? 61.427 118.769 -3.133 1.00 68.88 ? 171 ASP A OD2 1 ATOM 1354 N N . PRO A 1 183 ? 59.143 119.471 -7.551 1.00 51.65 ? 172 PRO A N 1 ATOM 1355 C CA . PRO A 1 183 ? 59.312 118.718 -8.816 1.00 51.42 ? 172 PRO A CA 1 ATOM 1356 C C . PRO A 1 183 ? 60.364 117.614 -8.767 1.00 54.29 ? 172 PRO A C 1 ATOM 1357 O O . PRO A 1 183 ? 60.317 116.701 -9.590 1.00 53.22 ? 172 PRO A O 1 ATOM 1358 C CB . PRO A 1 183 ? 59.658 119.803 -9.852 1.00 52.97 ? 172 PRO A CB 1 ATOM 1359 C CG . PRO A 1 183 ? 59.453 121.109 -9.177 1.00 57.00 ? 172 PRO A CG 1 ATOM 1360 C CD . PRO A 1 183 ? 59.527 120.893 -7.712 1.00 52.70 ? 172 PRO A CD 1 ATOM 1361 N N . GLN A 1 184 ? 61.283 117.668 -7.785 1.00 50.44 ? 173 GLN A N 1 ATOM 1362 C CA . GLN A 1 184 ? 62.291 116.620 -7.610 1.00 50.50 ? 173 GLN A CA 1 ATOM 1363 C C . GLN A 1 184 ? 61.668 115.288 -7.165 1.00 52.53 ? 173 GLN A C 1 ATOM 1364 O O . GLN A 1 184 ? 62.347 114.257 -7.255 1.00 52.21 ? 173 GLN A O 1 ATOM 1365 C CB . GLN A 1 184 ? 63.397 117.064 -6.631 1.00 52.85 ? 173 GLN A CB 1 ATOM 1366 C CG . GLN A 1 184 ? 64.167 118.332 -7.074 1.00 93.95 ? 173 GLN A CG 1 ATOM 1367 C CD . GLN A 1 184 ? 64.764 118.254 -8.483 1.00 126.49 ? 173 GLN A CD 1 ATOM 1368 O OE1 . GLN A 1 184 ? 65.743 117.534 -8.747 1.00 125.67 ? 173 GLN A OE1 1 ATOM 1369 N NE2 . GLN A 1 184 ? 64.182 118.999 -9.423 1.00 115.98 ? 173 GLN A NE2 1 ATOM 1370 N N . HIS A 1 185 ? 60.370 115.302 -6.711 1.00 47.30 ? 174 HIS A N 1 ATOM 1371 C CA . HIS A 1 185 ? 59.696 114.103 -6.235 1.00 45.71 ? 174 HIS A CA 1 ATOM 1372 C C . HIS A 1 185 ? 58.571 113.615 -7.136 1.00 51.05 ? 174 HIS A C 1 ATOM 1373 O O . HIS A 1 185 ? 57.982 112.582 -6.821 1.00 53.12 ? 174 HIS A O 1 ATOM 1374 C CB . HIS A 1 185 ? 59.247 114.249 -4.790 1.00 45.73 ? 174 HIS A CB 1 ATOM 1375 C CG . HIS A 1 185 ? 60.419 114.342 -3.856 1.00 49.28 ? 174 HIS A CG 1 ATOM 1376 N ND1 . HIS A 1 185 ? 61.420 113.368 -3.843 1.00 50.50 ? 174 HIS A ND1 1 ATOM 1377 C CD2 . HIS A 1 185 ? 60.752 115.321 -2.979 1.00 50.67 ? 174 HIS A CD2 1 ATOM 1378 C CE1 . HIS A 1 185 ? 62.312 113.785 -2.959 1.00 49.50 ? 174 HIS A CE1 1 ATOM 1379 N NE2 . HIS A 1 185 ? 61.952 114.947 -2.407 1.00 50.08 ? 174 HIS A NE2 1 ATOM 1380 N N . TYR A 1 186 ? 58.303 114.299 -8.268 1.00 45.18 ? 175 TYR A N 1 ATOM 1381 C CA . TYR A 1 186 ? 57.305 113.813 -9.240 1.00 44.38 ? 175 TYR A CA 1 ATOM 1382 C C . TYR A 1 186 ? 57.879 113.957 -10.631 1.00 46.71 ? 175 TYR A C 1 ATOM 1383 O O . TYR A 1 186 ? 58.909 114.602 -10.792 1.00 46.32 ? 175 TYR A O 1 ATOM 1384 C CB . TYR A 1 186 ? 55.903 114.480 -9.106 1.00 44.93 ? 175 TYR A CB 1 ATOM 1385 C CG . TYR A 1 186 ? 55.861 115.974 -9.385 1.00 46.10 ? 175 TYR A CG 1 ATOM 1386 C CD1 . TYR A 1 186 ? 55.736 116.459 -10.687 1.00 47.05 ? 175 TYR A CD1 1 ATOM 1387 C CD2 . TYR A 1 186 ? 55.868 116.899 -8.344 1.00 47.56 ? 175 TYR A CD2 1 ATOM 1388 C CE1 . TYR A 1 186 ? 55.675 117.829 -10.952 1.00 46.20 ? 175 TYR A CE1 1 ATOM 1389 C CE2 . TYR A 1 186 ? 55.808 118.273 -8.594 1.00 49.44 ? 175 TYR A CE2 1 ATOM 1390 C CZ . TYR A 1 186 ? 55.720 118.736 -9.902 1.00 59.84 ? 175 TYR A CZ 1 ATOM 1391 O OH . TYR A 1 186 ? 55.640 120.092 -10.159 1.00 63.61 ? 175 TYR A OH 1 ATOM 1392 N N . GLU A 1 187 ? 57.234 113.358 -11.627 1.00 41.86 ? 176 GLU A N 1 ATOM 1393 C CA . GLU A 1 187 ? 57.633 113.409 -13.044 1.00 40.74 ? 176 GLU A CA 1 ATOM 1394 C C . GLU A 1 187 ? 56.360 113.264 -13.884 1.00 49.90 ? 176 GLU A C 1 ATOM 1395 O O . GLU A 1 187 ? 55.303 112.816 -13.384 1.00 49.55 ? 176 GLU A O 1 ATOM 1396 C CB . GLU A 1 187 ? 58.726 112.377 -13.407 1.00 40.61 ? 176 GLU A CB 1 ATOM 1397 C CG . GLU A 1 187 ? 58.266 110.945 -13.254 1.00 39.39 ? 176 GLU A CG 1 ATOM 1398 C CD . GLU A 1 187 ? 59.308 109.865 -13.346 1.00 49.90 ? 176 GLU A CD 1 ATOM 1399 O OE1 . GLU A 1 187 ? 58.950 108.695 -13.089 1.00 49.86 ? 176 GLU A OE1 1 ATOM 1400 O OE2 . GLU A 1 187 ? 60.484 110.183 -13.622 1.00 51.28 ? 176 GLU A OE2 1 ATOM 1401 N N . GLY A 1 188 ? 56.453 113.705 -15.131 1.00 49.24 ? 177 GLY A N 1 ATOM 1402 C CA . GLY A 1 188 ? 55.277 113.836 -15.977 1.00 50.20 ? 177 GLY A CA 1 ATOM 1403 C C . GLY A 1 188 ? 54.502 115.043 -15.474 1.00 57.15 ? 177 GLY A C 1 ATOM 1404 O O . GLY A 1 188 ? 55.042 115.864 -14.708 1.00 56.25 ? 177 GLY A O 1 ATOM 1405 N N . ASN A 1 189 ? 53.226 115.154 -15.860 1.00 57.46 ? 178 ASN A N 1 ATOM 1406 C CA . ASN A 1 189 ? 52.401 116.300 -15.429 1.00 58.56 ? 178 ASN A CA 1 ATOM 1407 C C . ASN A 1 189 ? 51.297 115.900 -14.504 1.00 61.39 ? 178 ASN A C 1 ATOM 1408 O O . ASN A 1 189 ? 50.841 114.744 -14.563 1.00 60.37 ? 178 ASN A O 1 ATOM 1409 C CB . ASN A 1 189 ? 51.819 117.060 -16.647 1.00 63.58 ? 178 ASN A CB 1 ATOM 1410 C CG . ASN A 1 189 ? 52.867 117.571 -17.607 1.00 90.13 ? 178 ASN A CG 1 ATOM 1411 O OD1 . ASN A 1 189 ? 53.645 118.497 -17.310 1.00 78.68 ? 178 ASN A OD1 1 ATOM 1412 N ND2 . ASN A 1 189 ? 52.924 116.945 -18.770 1.00 85.75 ? 178 ASN A ND2 1 ATOM 1413 N N . PHE A 1 190 ? 50.857 116.859 -13.654 1.00 58.44 ? 179 PHE A N 1 ATOM 1414 C CA . PHE A 1 190 ? 49.750 116.635 -12.749 1.00 58.01 ? 179 PHE A CA 1 ATOM 1415 C C . PHE A 1 190 ? 48.465 116.513 -13.562 1.00 63.00 ? 179 PHE A C 1 ATOM 1416 O O . PHE A 1 190 ? 48.270 117.240 -14.541 1.00 61.98 ? 179 PHE A O 1 ATOM 1417 C CB . PHE A 1 190 ? 49.611 117.774 -11.744 1.00 59.69 ? 179 PHE A CB 1 ATOM 1418 C CG . PHE A 1 190 ? 50.453 117.664 -10.499 1.00 62.74 ? 179 PHE A CG 1 ATOM 1419 C CD1 . PHE A 1 190 ? 50.262 116.622 -9.596 1.00 66.92 ? 179 PHE A CD1 1 ATOM 1420 C CD2 . PHE A 1 190 ? 51.377 118.650 -10.178 1.00 66.05 ? 179 PHE A CD2 1 ATOM 1421 C CE1 . PHE A 1 190 ? 51.041 116.528 -8.443 1.00 67.53 ? 179 PHE A CE1 1 ATOM 1422 C CE2 . PHE A 1 190 ? 52.124 118.578 -9.002 1.00 68.68 ? 179 PHE A CE2 1 ATOM 1423 C CZ . PHE A 1 190 ? 51.955 117.514 -8.150 1.00 66.82 ? 179 PHE A CZ 1 ATOM 1424 N N . HIS A 1 191 ? 47.622 115.552 -13.157 1.00 60.82 ? 180 HIS A N 1 ATOM 1425 C CA . HIS A 1 191 ? 46.296 115.284 -13.702 1.00 61.63 ? 180 HIS A CA 1 ATOM 1426 C C . HIS A 1 191 ? 45.353 115.522 -12.520 1.00 63.50 ? 180 HIS A C 1 ATOM 1427 O O . HIS A 1 191 ? 45.467 114.822 -11.499 1.00 61.75 ? 180 HIS A O 1 ATOM 1428 C CB . HIS A 1 191 ? 46.197 113.845 -14.253 1.00 63.79 ? 180 HIS A CB 1 ATOM 1429 C CG . HIS A 1 191 ? 47.094 113.609 -15.431 1.00 68.75 ? 180 HIS A CG 1 ATOM 1430 N ND1 . HIS A 1 191 ? 48.373 113.087 -15.276 1.00 71.33 ? 180 HIS A ND1 1 ATOM 1431 C CD2 . HIS A 1 191 ? 46.899 113.902 -16.742 1.00 71.32 ? 180 HIS A CD2 1 ATOM 1432 C CE1 . HIS A 1 191 ? 48.898 113.047 -16.496 1.00 70.96 ? 180 HIS A CE1 1 ATOM 1433 N NE2 . HIS A 1 191 ? 48.048 113.525 -17.412 1.00 71.28 ? 180 HIS A NE2 1 ATOM 1434 N N . TYR A 1 192 ? 44.506 116.585 -12.617 1.00 59.25 ? 181 TYR A N 1 ATOM 1435 C CA . TYR A 1 192 ? 43.595 116.972 -11.537 1.00 58.12 ? 181 TYR A CA 1 ATOM 1436 C C . TYR A 1 192 ? 42.239 116.329 -11.662 1.00 61.69 ? 181 TYR A C 1 ATOM 1437 O O . TYR A 1 192 ? 41.856 115.887 -12.741 1.00 62.47 ? 181 TYR A O 1 ATOM 1438 C CB . TYR A 1 192 ? 43.477 118.504 -11.386 1.00 58.23 ? 181 TYR A CB 1 ATOM 1439 C CG . TYR A 1 192 ? 44.804 119.188 -11.142 1.00 59.55 ? 181 TYR A CG 1 ATOM 1440 C CD1 . TYR A 1 192 ? 45.626 119.551 -12.203 1.00 61.56 ? 181 TYR A CD1 1 ATOM 1441 C CD2 . TYR A 1 192 ? 45.234 119.486 -9.850 1.00 59.76 ? 181 TYR A CD2 1 ATOM 1442 C CE1 . TYR A 1 192 ? 46.846 120.185 -11.988 1.00 62.23 ? 181 TYR A CE1 1 ATOM 1443 C CE2 . TYR A 1 192 ? 46.456 120.112 -9.621 1.00 60.14 ? 181 TYR A CE2 1 ATOM 1444 C CZ . TYR A 1 192 ? 47.261 120.456 -10.694 1.00 69.04 ? 181 TYR A CZ 1 ATOM 1445 O OH . TYR A 1 192 ? 48.464 121.086 -10.474 1.00 69.91 ? 181 TYR A OH 1 ATOM 1446 N N . ILE A 1 193 ? 41.553 116.213 -10.538 1.00 57.64 ? 182 ILE A N 1 ATOM 1447 C CA . ILE A 1 193 ? 40.207 115.678 -10.402 1.00 57.84 ? 182 ILE A CA 1 ATOM 1448 C C . ILE A 1 193 ? 39.550 116.639 -9.413 1.00 62.07 ? 182 ILE A C 1 ATOM 1449 O O . ILE A 1 193 ? 40.100 116.842 -8.334 1.00 61.90 ? 182 ILE A O 1 ATOM 1450 C CB . ILE A 1 193 ? 40.166 114.188 -9.903 1.00 60.78 ? 182 ILE A CB 1 ATOM 1451 C CG1 . ILE A 1 193 ? 41.050 113.217 -10.737 1.00 60.96 ? 182 ILE A CG1 1 ATOM 1452 C CG2 . ILE A 1 193 ? 38.728 113.663 -9.816 1.00 59.78 ? 182 ILE A CG2 1 ATOM 1453 C CD1 . ILE A 1 193 ? 42.434 112.953 -10.166 1.00 65.86 ? 182 ILE A CD1 1 ATOM 1454 N N . ASN A 1 194 ? 38.422 117.265 -9.782 1.00 59.26 ? 183 ASN A N 1 ATOM 1455 C CA . ASN A 1 194 ? 37.733 118.202 -8.884 1.00 59.47 ? 183 ASN A CA 1 ATOM 1456 C C . ASN A 1 194 ? 37.014 117.482 -7.757 1.00 64.13 ? 183 ASN A C 1 ATOM 1457 O O . ASN A 1 194 ? 36.525 116.364 -7.940 1.00 62.98 ? 183 ASN A O 1 ATOM 1458 C CB . ASN A 1 194 ? 36.768 119.144 -9.626 1.00 58.02 ? 183 ASN A CB 1 ATOM 1459 C CG . ASN A 1 194 ? 37.419 119.979 -10.699 1.00 82.18 ? 183 ASN A CG 1 ATOM 1460 O OD1 . ASN A 1 194 ? 38.028 121.035 -10.461 1.00 74.19 ? 183 ASN A OD1 1 ATOM 1461 N ND2 . ASN A 1 194 ? 37.270 119.527 -11.914 1.00 80.25 ? 183 ASN A ND2 1 ATOM 1462 N N . LEU A 1 195 ? 36.959 118.123 -6.583 1.00 61.98 ? 184 LEU A N 1 ATOM 1463 C CA . LEU A 1 195 ? 36.259 117.552 -5.436 1.00 62.44 ? 184 LEU A CA 1 ATOM 1464 C C . LEU A 1 195 ? 34.770 117.529 -5.753 1.00 67.95 ? 184 LEU A C 1 ATOM 1465 O O . LEU A 1 195 ? 34.271 118.403 -6.479 1.00 67.45 ? 184 LEU A O 1 ATOM 1466 C CB . LEU A 1 195 ? 36.497 118.399 -4.159 1.00 62.30 ? 184 LEU A CB 1 ATOM 1467 C CG . LEU A 1 195 ? 37.940 118.591 -3.672 1.00 65.65 ? 184 LEU A CG 1 ATOM 1468 C CD1 . LEU A 1 195 ? 37.973 119.415 -2.423 1.00 65.05 ? 184 LEU A CD1 1 ATOM 1469 C CD2 . LEU A 1 195 ? 38.629 117.268 -3.431 1.00 67.97 ? 184 LEU A CD2 1 ATOM 1470 N N . ILE A 1 196 ? 34.065 116.530 -5.223 1.00 65.27 ? 185 ILE A N 1 ATOM 1471 C CA . ILE A 1 196 ? 32.622 116.413 -5.397 1.00 65.56 ? 185 ILE A CA 1 ATOM 1472 C C . ILE A 1 196 ? 31.941 117.653 -4.783 1.00 74.37 ? 185 ILE A C 1 ATOM 1473 O O . ILE A 1 196 ? 31.179 118.347 -5.455 1.00 75.40 ? 185 ILE A O 1 ATOM 1474 C CB . ILE A 1 196 ? 32.152 115.074 -4.806 1.00 67.55 ? 185 ILE A CB 1 ATOM 1475 C CG1 . ILE A 1 196 ? 32.631 113.911 -5.722 1.00 66.61 ? 185 ILE A CG1 1 ATOM 1476 C CG2 . ILE A 1 196 ? 30.630 115.058 -4.567 1.00 68.07 ? 185 ILE A CG2 1 ATOM 1477 C CD1 . ILE A 1 196 ? 32.696 112.658 -5.093 1.00 66.45 ? 185 ILE A CD1 1 ATOM 1478 N N . LYS A 1 197 ? 32.298 117.958 -3.541 1.00 72.95 ? 186 LYS A N 1 ATOM 1479 C CA . LYS A 1 197 ? 31.845 119.122 -2.792 1.00 72.85 ? 186 LYS A CA 1 ATOM 1480 C C . LYS A 1 197 ? 33.016 119.603 -1.941 1.00 79.02 ? 186 LYS A C 1 ATOM 1481 O O . LYS A 1 197 ? 33.832 118.782 -1.491 1.00 79.71 ? 186 LYS A O 1 ATOM 1482 C CB . LYS A 1 197 ? 30.645 118.757 -1.884 1.00 74.10 ? 186 LYS A CB 1 ATOM 1483 C CG . LYS A 1 197 ? 30.923 117.697 -0.811 1.00 71.33 ? 186 LYS A CG 1 ATOM 1484 C CD . LYS A 1 197 ? 29.676 117.228 -0.078 1.00 71.98 ? 186 LYS A CD 1 ATOM 1485 C CE . LYS A 1 197 ? 30.003 116.274 1.050 1.00 77.21 ? 186 LYS A CE 1 ATOM 1486 N NZ . LYS A 1 197 ? 30.609 115.001 0.567 1.00 82.09 ? 186 LYS A NZ 1 ATOM 1487 N N . THR A 1 198 ? 33.084 120.920 -1.686 1.00 74.54 ? 187 THR A N 1 ATOM 1488 C CA . THR A 1 198 ? 34.086 121.489 -0.775 1.00 73.05 ? 187 THR A CA 1 ATOM 1489 C C . THR A 1 198 ? 33.771 120.972 0.660 1.00 72.15 ? 187 THR A C 1 ATOM 1490 O O . THR A 1 198 ? 32.637 120.559 0.932 1.00 71.61 ? 187 THR A O 1 ATOM 1491 C CB . THR A 1 198 ? 34.124 123.039 -0.875 1.00 79.90 ? 187 THR A CB 1 ATOM 1492 O OG1 . THR A 1 198 ? 35.251 123.528 -0.136 1.00 78.54 ? 187 THR A OG1 1 ATOM 1493 C CG2 . THR A 1 198 ? 32.834 123.710 -0.370 1.00 77.68 ? 187 THR A CG2 1 ATOM 1494 N N . GLY A 1 199 ? 34.774 120.970 1.534 1.00 64.42 ? 188 GLY A N 1 ATOM 1495 C CA . GLY A 1 199 ? 34.600 120.500 2.899 1.00 62.02 ? 188 GLY A CA 1 ATOM 1496 C C . GLY A 1 199 ? 35.216 119.140 3.150 1.00 61.22 ? 188 GLY A C 1 ATOM 1497 O O . GLY A 1 199 ? 35.475 118.792 4.299 1.00 61.48 ? 188 GLY A O 1 ATOM 1498 N N . VAL A 1 200 ? 35.454 118.359 2.075 1.00 53.06 ? 189 VAL A N 1 ATOM 1499 C CA . VAL A 1 200 ? 36.035 117.019 2.132 1.00 50.75 ? 189 VAL A CA 1 ATOM 1500 C C . VAL A 1 200 ? 37.073 116.890 1.022 1.00 53.73 ? 189 VAL A C 1 ATOM 1501 O O . VAL A 1 200 ? 36.909 117.526 -0.019 1.00 54.20 ? 189 VAL A O 1 ATOM 1502 C CB . VAL A 1 200 ? 34.971 115.902 1.970 1.00 53.78 ? 189 VAL A CB 1 ATOM 1503 C CG1 . VAL A 1 200 ? 35.486 114.580 2.524 1.00 53.82 ? 189 VAL A CG1 1 ATOM 1504 C CG2 . VAL A 1 200 ? 33.653 116.264 2.634 1.00 53.46 ? 189 VAL A CG2 1 ATOM 1505 N N . TRP A 1 201 ? 38.133 116.059 1.224 1.00 48.15 ? 190 TRP A N 1 ATOM 1506 C CA . TRP A 1 201 ? 39.115 115.756 0.165 1.00 46.21 ? 190 TRP A CA 1 ATOM 1507 C C . TRP A 1 201 ? 38.712 114.430 -0.495 1.00 51.47 ? 190 TRP A C 1 ATOM 1508 O O . TRP A 1 201 ? 39.474 113.455 -0.518 1.00 51.50 ? 190 TRP A O 1 ATOM 1509 C CB . TRP A 1 201 ? 40.552 115.695 0.691 1.00 42.67 ? 190 TRP A CB 1 ATOM 1510 C CG . TRP A 1 201 ? 41.102 116.999 1.165 1.00 41.73 ? 190 TRP A CG 1 ATOM 1511 C CD1 . TRP A 1 201 ? 41.417 117.334 2.453 1.00 44.45 ? 190 TRP A CD1 1 ATOM 1512 C CD2 . TRP A 1 201 ? 41.512 118.100 0.348 1.00 40.08 ? 190 TRP A CD2 1 ATOM 1513 N NE1 . TRP A 1 201 ? 41.996 118.581 2.487 1.00 43.05 ? 190 TRP A NE1 1 ATOM 1514 C CE2 . TRP A 1 201 ? 42.062 119.076 1.209 1.00 43.92 ? 190 TRP A CE2 1 ATOM 1515 C CE3 . TRP A 1 201 ? 41.433 118.373 -1.031 1.00 40.28 ? 190 TRP A CE3 1 ATOM 1516 C CZ2 . TRP A 1 201 ? 42.552 120.300 0.732 1.00 43.40 ? 190 TRP A CZ2 1 ATOM 1517 C CZ3 . TRP A 1 201 ? 41.917 119.576 -1.507 1.00 41.36 ? 190 TRP A CZ3 1 ATOM 1518 C CH2 . TRP A 1 201 ? 42.491 120.519 -0.636 1.00 42.48 ? 190 TRP A CH2 1 ATOM 1519 N N . GLN A 1 202 ? 37.479 114.408 -0.994 1.00 48.40 ? 191 GLN A N 1 ATOM 1520 C CA . GLN A 1 202 ? 36.856 113.252 -1.624 1.00 48.41 ? 191 GLN A CA 1 ATOM 1521 C C . GLN A 1 202 ? 36.508 113.593 -3.064 1.00 53.63 ? 191 GLN A C 1 ATOM 1522 O O . GLN A 1 202 ? 36.050 114.703 -3.368 1.00 53.83 ? 191 GLN A O 1 ATOM 1523 C CB . GLN A 1 202 ? 35.621 112.860 -0.824 1.00 49.45 ? 191 GLN A CB 1 ATOM 1524 C CG . GLN A 1 202 ? 34.991 111.557 -1.222 1.00 53.69 ? 191 GLN A CG 1 ATOM 1525 C CD . GLN A 1 202 ? 33.833 111.269 -0.319 1.00 55.89 ? 191 GLN A CD 1 ATOM 1526 O OE1 . GLN A 1 202 ? 32.907 112.071 -0.180 1.00 50.06 ? 191 GLN A OE1 1 ATOM 1527 N NE2 . GLN A 1 202 ? 33.875 110.121 0.323 1.00 44.10 ? 191 GLN A NE2 1 ATOM 1528 N N . ILE A 1 203 ? 36.824 112.658 -3.950 1.00 51.73 ? 192 ILE A N 1 ATOM 1529 C CA . ILE A 1 203 ? 36.632 112.741 -5.396 1.00 51.54 ? 192 ILE A CA 1 ATOM 1530 C C . ILE A 1 203 ? 35.838 111.522 -5.877 1.00 58.08 ? 192 ILE A C 1 ATOM 1531 O O . ILE A 1 203 ? 35.654 110.552 -5.126 1.00 57.10 ? 192 ILE A O 1 ATOM 1532 C CB . ILE A 1 203 ? 37.985 112.898 -6.145 1.00 54.02 ? 192 ILE A CB 1 ATOM 1533 C CG1 . ILE A 1 203 ? 38.959 111.738 -5.805 1.00 54.28 ? 192 ILE A CG1 1 ATOM 1534 C CG2 . ILE A 1 203 ? 38.596 114.274 -5.876 1.00 55.12 ? 192 ILE A CG2 1 ATOM 1535 C CD1 . ILE A 1 203 ? 39.982 111.407 -6.863 1.00 57.46 ? 192 ILE A CD1 1 ATOM 1536 N N . GLN A 1 204 ? 35.330 111.603 -7.116 1.00 56.75 ? 193 GLN A N 1 ATOM 1537 C CA . GLN A 1 204 ? 34.551 110.542 -7.743 1.00 57.21 ? 193 GLN A CA 1 ATOM 1538 C C . GLN A 1 204 ? 35.490 109.519 -8.396 1.00 60.38 ? 193 GLN A C 1 ATOM 1539 O O . GLN A 1 204 ? 36.433 109.904 -9.091 1.00 59.80 ? 193 GLN A O 1 ATOM 1540 C CB . GLN A 1 204 ? 33.576 111.164 -8.770 1.00 58.85 ? 193 GLN A CB 1 ATOM 1541 C CG . GLN A 1 204 ? 32.626 110.184 -9.486 1.00 78.40 ? 193 GLN A CG 1 ATOM 1542 C CD . GLN A 1 204 ? 31.516 109.614 -8.635 1.00 98.62 ? 193 GLN A CD 1 ATOM 1543 O OE1 . GLN A 1 204 ? 30.868 110.319 -7.851 1.00 96.71 ? 193 GLN A OE1 1 ATOM 1544 N NE2 . GLN A 1 204 ? 31.226 108.330 -8.833 1.00 90.34 ? 193 GLN A NE2 1 ATOM 1545 N N . MET A 1 205 ? 35.228 108.227 -8.156 1.00 56.57 ? 194 MET A N 1 ATOM 1546 C CA . MET A 1 205 ? 35.957 107.103 -8.747 1.00 57.18 ? 194 MET A CA 1 ATOM 1547 C C . MET A 1 205 ? 35.025 106.397 -9.765 1.00 65.06 ? 194 MET A C 1 ATOM 1548 O O . MET A 1 205 ? 33.863 106.092 -9.443 1.00 65.86 ? 194 MET A O 1 ATOM 1549 C CB . MET A 1 205 ? 36.436 106.135 -7.669 1.00 58.75 ? 194 MET A CB 1 ATOM 1550 C CG . MET A 1 205 ? 37.351 105.058 -8.201 1.00 61.77 ? 194 MET A CG 1 ATOM 1551 S SD . MET A 1 205 ? 38.644 104.583 -7.042 1.00 65.16 ? 194 MET A SD 1 ATOM 1552 C CE . MET A 1 205 ? 37.690 103.817 -5.799 1.00 61.74 ? 194 MET A CE 1 ATOM 1553 N N . LYS A 1 206 ? 35.530 106.167 -10.987 1.00 60.51 ? 195 LYS A N 1 ATOM 1554 C CA . LYS A 1 206 ? 34.732 105.608 -12.075 1.00 59.62 ? 195 LYS A CA 1 ATOM 1555 C C . LYS A 1 206 ? 34.798 104.078 -12.198 1.00 65.92 ? 195 LYS A C 1 ATOM 1556 O O . LYS A 1 206 ? 33.998 103.504 -12.936 1.00 68.14 ? 195 LYS A O 1 ATOM 1557 C CB . LYS A 1 206 ? 35.093 106.302 -13.399 1.00 60.52 ? 195 LYS A CB 1 ATOM 1558 C CG . LYS A 1 206 ? 34.786 107.818 -13.414 1.00 55.46 ? 195 LYS A CG 1 ATOM 1559 C CD . LYS A 1 206 ? 35.617 108.566 -14.469 1.00 66.01 ? 195 LYS A CD 1 ATOM 1560 C CE . LYS A 1 206 ? 35.290 110.047 -14.566 1.00 70.48 ? 195 LYS A CE 1 ATOM 1561 N NZ . LYS A 1 206 ? 36.008 110.705 -15.689 1.00 66.32 ? 195 LYS A NZ 1 ATOM 1562 N N . GLY A 1 207 ? 35.696 103.430 -11.453 1.00 61.71 ? 196 GLY A N 1 ATOM 1563 C CA . GLY A 1 207 ? 35.842 101.976 -11.455 1.00 60.02 ? 196 GLY A CA 1 ATOM 1564 C C . GLY A 1 207 ? 37.136 101.461 -10.873 1.00 61.79 ? 196 GLY A C 1 ATOM 1565 O O . GLY A 1 207 ? 38.147 102.146 -10.942 1.00 63.98 ? 196 GLY A O 1 ATOM 1566 N N . VAL A 1 208 ? 37.113 100.249 -10.309 1.00 55.34 ? 197 VAL A N 1 ATOM 1567 C CA . VAL A 1 208 ? 38.266 99.553 -9.716 1.00 54.17 ? 197 VAL A CA 1 ATOM 1568 C C . VAL A 1 208 ? 38.424 98.231 -10.475 1.00 61.00 ? 197 VAL A C 1 ATOM 1569 O O . VAL A 1 208 ? 37.501 97.406 -10.470 1.00 59.32 ? 197 VAL A O 1 ATOM 1570 C CB . VAL A 1 208 ? 38.137 99.312 -8.169 1.00 54.76 ? 197 VAL A CB 1 ATOM 1571 C CG1 . VAL A 1 208 ? 39.376 98.612 -7.595 1.00 53.54 ? 197 VAL A CG1 1 ATOM 1572 C CG2 . VAL A 1 208 ? 37.872 100.607 -7.437 1.00 54.02 ? 197 VAL A CG2 1 ATOM 1573 N N . SER A 1 209 ? 39.593 98.007 -11.082 1.00 61.12 ? 198 SER A N 1 ATOM 1574 C CA . SER A 1 209 ? 39.790 96.781 -11.856 1.00 62.86 ? 198 SER A CA 1 ATOM 1575 C C . SER A 1 209 ? 40.897 95.872 -11.357 1.00 70.44 ? 198 SER A C 1 ATOM 1576 O O . SER A 1 209 ? 41.975 96.335 -11.023 1.00 70.87 ? 198 SER A O 1 ATOM 1577 C CB . SER A 1 209 ? 39.986 97.088 -13.339 1.00 65.91 ? 198 SER A CB 1 ATOM 1578 O OG . SER A 1 209 ? 40.724 98.275 -13.571 1.00 75.02 ? 198 SER A OG 1 ATOM 1579 N N . VAL A 1 210 ? 40.615 94.566 -11.336 1.00 69.97 ? 199 VAL A N 1 ATOM 1580 C CA . VAL A 1 210 ? 41.555 93.502 -10.971 1.00 70.95 ? 199 VAL A CA 1 ATOM 1581 C C . VAL A 1 210 ? 41.916 92.769 -12.268 1.00 80.49 ? 199 VAL A C 1 ATOM 1582 O O . VAL A 1 210 ? 41.082 92.069 -12.849 1.00 80.28 ? 199 VAL A O 1 ATOM 1583 C CB . VAL A 1 210 ? 41.014 92.570 -9.860 1.00 73.53 ? 199 VAL A CB 1 ATOM 1584 C CG1 . VAL A 1 210 ? 41.915 91.361 -9.645 1.00 73.01 ? 199 VAL A CG1 1 ATOM 1585 C CG2 . VAL A 1 210 ? 40.849 93.337 -8.568 1.00 73.07 ? 199 VAL A CG2 1 ATOM 1586 N N . GLY A 1 211 ? 43.134 93.009 -12.739 1.00 81.51 ? 200 GLY A N 1 ATOM 1587 C CA . GLY A 1 211 ? 43.640 92.452 -13.986 1.00 83.41 ? 200 GLY A CA 1 ATOM 1588 C C . GLY A 1 211 ? 43.383 93.402 -15.143 1.00 92.30 ? 200 GLY A C 1 ATOM 1589 O O . GLY A 1 211 ? 44.119 94.383 -15.317 1.00 92.34 ? 200 GLY A O 1 ATOM 1590 N N . SER A 1 212 ? 42.319 93.131 -15.931 1.00 91.35 ? 201 SER A N 1 ATOM 1591 C CA . SER A 1 212 ? 41.927 93.940 -17.102 1.00 91.91 ? 201 SER A CA 1 ATOM 1592 C C . SER A 1 212 ? 40.418 94.237 -17.147 1.00 96.67 ? 201 SER A C 1 ATOM 1593 O O . SER A 1 212 ? 39.957 94.922 -18.065 1.00 96.36 ? 201 SER A O 1 ATOM 1594 C CB . SER A 1 212 ? 42.353 93.240 -18.391 1.00 95.42 ? 201 SER A CB 1 ATOM 1595 O OG . SER A 1 212 ? 41.770 91.949 -18.489 1.00 104.11 ? 201 SER A OG 1 ATOM 1596 N N . SER A 1 213 ? 39.662 93.723 -16.152 1.00 93.35 ? 202 SER A N 1 ATOM 1597 C CA . SER A 1 213 ? 38.205 93.839 -16.051 1.00 92.91 ? 202 SER A CA 1 ATOM 1598 C C . SER A 1 213 ? 37.738 94.621 -14.808 1.00 95.96 ? 202 SER A C 1 ATOM 1599 O O . SER A 1 213 ? 38.212 94.336 -13.701 1.00 94.92 ? 202 SER A O 1 ATOM 1600 C CB . SER A 1 213 ? 37.572 92.448 -16.088 1.00 96.43 ? 202 SER A CB 1 ATOM 1601 O OG . SER A 1 213 ? 38.259 91.518 -15.264 1.00 103.18 ? 202 SER A OG 1 ATOM 1602 N N . THR A 1 214 ? 36.805 95.610 -15.004 1.00 92.09 ? 203 THR A N 1 ATOM 1603 C CA . THR A 1 214 ? 36.216 96.485 -13.959 1.00 91.05 ? 203 THR A CA 1 ATOM 1604 C C . THR A 1 214 ? 35.318 95.642 -13.061 1.00 92.01 ? 203 THR A C 1 ATOM 1605 O O . THR A 1 214 ? 34.093 95.752 -13.123 1.00 92.33 ? 203 THR A O 1 ATOM 1606 C CB . THR A 1 214 ? 35.451 97.696 -14.577 1.00 99.59 ? 203 THR A CB 1 ATOM 1607 O OG1 . THR A 1 214 ? 36.185 98.247 -15.677 1.00 104.71 ? 203 THR A OG1 1 ATOM 1608 C CG2 . THR A 1 214 ? 35.135 98.792 -13.551 1.00 93.90 ? 203 THR A CG2 1 ATOM 1609 N N . LEU A 1 215 ? 35.937 94.778 -12.246 1.00 85.02 ? 204 LEU A N 1 ATOM 1610 C CA . LEU A 1 215 ? 35.234 93.872 -11.357 1.00 83.08 ? 204 LEU A CA 1 ATOM 1611 C C . LEU A 1 215 ? 34.459 94.610 -10.256 1.00 82.61 ? 204 LEU A C 1 ATOM 1612 O O . LEU A 1 215 ? 33.463 94.074 -9.768 1.00 81.79 ? 204 LEU A O 1 ATOM 1613 C CB . LEU A 1 215 ? 36.193 92.793 -10.787 1.00 83.11 ? 204 LEU A CB 1 ATOM 1614 C CG . LEU A 1 215 ? 36.937 91.877 -11.799 1.00 87.70 ? 204 LEU A CG 1 ATOM 1615 C CD1 . LEU A 1 215 ? 37.655 90.754 -11.093 1.00 87.28 ? 204 LEU A CD1 1 ATOM 1616 C CD2 . LEU A 1 215 ? 35.988 91.264 -12.830 1.00 91.61 ? 204 LEU A CD2 1 ATOM 1617 N N . LEU A 1 216 ? 34.880 95.858 -9.916 1.00 76.41 ? 205 LEU A N 1 ATOM 1618 C CA . LEU A 1 216 ? 34.273 96.694 -8.864 1.00 74.76 ? 205 LEU A CA 1 ATOM 1619 C C . LEU A 1 216 ? 34.080 98.155 -9.254 1.00 76.29 ? 205 LEU A C 1 ATOM 1620 O O . LEU A 1 216 ? 34.674 98.607 -10.226 1.00 73.86 ? 205 LEU A O 1 ATOM 1621 C CB . LEU A 1 216 ? 35.100 96.594 -7.572 1.00 74.42 ? 205 LEU A CB 1 ATOM 1622 C CG . LEU A 1 216 ? 34.957 95.292 -6.818 1.00 78.28 ? 205 LEU A CG 1 ATOM 1623 C CD1 . LEU A 1 216 ? 36.266 94.864 -6.229 1.00 78.42 ? 205 LEU A CD1 1 ATOM 1624 C CD2 . LEU A 1 216 ? 33.855 95.385 -5.782 1.00 80.71 ? 205 LEU A CD2 1 ATOM 1625 N N . CYS A 1 217 ? 33.238 98.892 -8.482 1.00 74.59 ? 206 CYS A N 1 ATOM 1626 C CA . CYS A 1 217 ? 32.899 100.315 -8.677 1.00 75.04 ? 206 CYS A CA 1 ATOM 1627 C C . CYS A 1 217 ? 32.439 100.600 -10.141 1.00 80.81 ? 206 CYS A C 1 ATOM 1628 O O . CYS A 1 217 ? 32.767 101.630 -10.728 1.00 80.42 ? 206 CYS A O 1 ATOM 1629 C CB . CYS A 1 217 ? 34.069 101.194 -8.234 1.00 75.60 ? 206 CYS A CB 1 ATOM 1630 S SG . CYS A 1 217 ? 33.734 102.975 -8.228 1.00 79.74 ? 206 CYS A SG 1 ATOM 1631 N N . GLU A 1 218 ? 31.642 99.663 -10.709 1.00 79.45 ? 207 GLU A N 1 ATOM 1632 C CA . GLU A 1 218 ? 31.125 99.702 -12.085 1.00 79.97 ? 207 GLU A CA 1 ATOM 1633 C C . GLU A 1 218 ? 30.162 100.848 -12.312 1.00 85.15 ? 207 GLU A C 1 ATOM 1634 O O . GLU A 1 218 ? 30.236 101.516 -13.348 1.00 84.36 ? 207 GLU A O 1 ATOM 1635 C CB . GLU A 1 218 ? 30.444 98.383 -12.467 1.00 81.48 ? 207 GLU A CB 1 ATOM 1636 C CG . GLU A 1 218 ? 31.289 97.136 -12.258 1.00 94.05 ? 207 GLU A CG 1 ATOM 1637 C CD . GLU A 1 218 ? 30.895 96.258 -11.083 1.00 119.31 ? 207 GLU A CD 1 ATOM 1638 O OE1 . GLU A 1 218 ? 30.951 95.013 -11.234 1.00 112.42 ? 207 GLU A OE1 1 ATOM 1639 O OE2 . GLU A 1 218 ? 30.539 96.808 -10.012 1.00 113.01 ? 207 GLU A OE2 1 ATOM 1640 N N . ASP A 1 219 ? 29.264 101.084 -11.342 1.00 83.49 ? 208 ASP A N 1 ATOM 1641 C CA . ASP A 1 219 ? 28.266 102.158 -11.438 1.00 84.55 ? 208 ASP A CA 1 ATOM 1642 C C . ASP A 1 219 ? 28.742 103.476 -10.789 1.00 88.66 ? 208 ASP A C 1 ATOM 1643 O O . ASP A 1 219 ? 27.936 104.398 -10.595 1.00 88.58 ? 208 ASP A O 1 ATOM 1644 C CB . ASP A 1 219 ? 26.892 101.695 -10.883 1.00 87.01 ? 208 ASP A CB 1 ATOM 1645 C CG . ASP A 1 219 ? 26.322 100.469 -11.579 1.00 99.50 ? 208 ASP A CG 1 ATOM 1646 O OD1 . ASP A 1 219 ? 26.097 100.536 -12.811 1.00 101.10 ? 208 ASP A OD1 1 ATOM 1647 O OD2 . ASP A 1 219 ? 26.123 99.431 -10.894 1.00 103.78 ? 208 ASP A OD2 1 ATOM 1648 N N . GLY A 1 220 ? 30.048 103.554 -10.495 1.00 83.73 ? 209 GLY A N 1 ATOM 1649 C CA . GLY A 1 220 ? 30.678 104.712 -9.871 1.00 81.85 ? 209 GLY A CA 1 ATOM 1650 C C . GLY A 1 220 ? 30.667 104.639 -8.358 1.00 82.11 ? 209 GLY A C 1 ATOM 1651 O O . GLY A 1 220 ? 29.800 103.990 -7.756 1.00 81.08 ? 209 GLY A O 1 ATOM 1652 N N . CYS A 1 221 ? 31.665 105.284 -7.731 1.00 76.21 ? 210 CYS A N 1 ATOM 1653 C CA . CYS A 1 221 ? 31.802 105.316 -6.275 1.00 74.20 ? 210 CYS A CA 1 ATOM 1654 C C . CYS A 1 221 ? 32.666 106.476 -5.833 1.00 71.92 ? 210 CYS A C 1 ATOM 1655 O O . CYS A 1 221 ? 33.076 107.296 -6.653 1.00 70.42 ? 210 CYS A O 1 ATOM 1656 C CB . CYS A 1 221 ? 32.301 103.986 -5.718 1.00 75.01 ? 210 CYS A CB 1 ATOM 1657 S SG . CYS A 1 221 ? 33.956 103.532 -6.279 1.00 79.77 ? 210 CYS A SG 1 ATOM 1658 N N . LEU A 1 222 ? 32.893 106.569 -4.523 1.00 66.13 ? 211 LEU A N 1 ATOM 1659 C CA . LEU A 1 222 ? 33.672 107.634 -3.895 1.00 63.62 ? 211 LEU A CA 1 ATOM 1660 C C . LEU A 1 222 ? 35.063 107.178 -3.501 1.00 59.47 ? 211 LEU A C 1 ATOM 1661 O O . LEU A 1 222 ? 35.287 106.005 -3.194 1.00 56.68 ? 211 LEU A O 1 ATOM 1662 C CB . LEU A 1 222 ? 32.944 108.176 -2.654 1.00 63.81 ? 211 LEU A CB 1 ATOM 1663 C CG . LEU A 1 222 ? 31.482 108.607 -2.801 1.00 67.76 ? 211 LEU A CG 1 ATOM 1664 C CD1 . LEU A 1 222 ? 30.888 108.942 -1.458 1.00 67.66 ? 211 LEU A CD1 1 ATOM 1665 C CD2 . LEU A 1 222 ? 31.341 109.769 -3.747 1.00 67.84 ? 211 LEU A CD2 1 ATOM 1666 N N . ALA A 1 223 ? 35.985 108.139 -3.497 1.00 54.30 ? 212 ALA A N 1 ATOM 1667 C CA . ALA A 1 223 ? 37.389 107.966 -3.122 1.00 52.53 ? 212 ALA A CA 1 ATOM 1668 C C . ALA A 1 223 ? 37.858 109.133 -2.260 1.00 50.88 ? 212 ALA A C 1 ATOM 1669 O O . ALA A 1 223 ? 38.025 110.264 -2.742 1.00 48.45 ? 212 ALA A O 1 ATOM 1670 C CB . ALA A 1 223 ? 38.263 107.859 -4.370 1.00 53.18 ? 212 ALA A CB 1 ATOM 1671 N N . LEU A 1 224 ? 38.032 108.861 -0.970 1.00 46.50 ? 213 LEU A N 1 ATOM 1672 C CA . LEU A 1 224 ? 38.601 109.834 -0.032 1.00 45.05 ? 213 LEU A CA 1 ATOM 1673 C C . LEU A 1 224 ? 40.133 109.708 -0.176 1.00 45.86 ? 213 LEU A C 1 ATOM 1674 O O . LEU A 1 224 ? 40.665 108.589 -0.131 1.00 45.08 ? 213 LEU A O 1 ATOM 1675 C CB . LEU A 1 224 ? 38.142 109.532 1.409 1.00 44.77 ? 213 LEU A CB 1 ATOM 1676 C CG . LEU A 1 224 ? 38.758 110.405 2.525 1.00 49.05 ? 213 LEU A CG 1 ATOM 1677 C CD1 . LEU A 1 224 ? 38.227 111.855 2.506 1.00 47.23 ? 213 LEU A CD1 1 ATOM 1678 C CD2 . LEU A 1 224 ? 38.576 109.732 3.876 1.00 51.33 ? 213 LEU A CD2 1 ATOM 1679 N N . VAL A 1 225 ? 40.817 110.826 -0.465 1.00 42.39 ? 214 VAL A N 1 ATOM 1680 C CA . VAL A 1 225 ? 42.284 110.850 -0.633 1.00 42.62 ? 214 VAL A CA 1 ATOM 1681 C C . VAL A 1 225 ? 42.860 111.247 0.727 1.00 46.27 ? 214 VAL A C 1 ATOM 1682 O O . VAL A 1 225 ? 42.878 112.420 1.093 1.00 45.10 ? 214 VAL A O 1 ATOM 1683 C CB . VAL A 1 225 ? 42.759 111.705 -1.837 1.00 45.97 ? 214 VAL A CB 1 ATOM 1684 C CG1 . VAL A 1 225 ? 44.250 111.501 -2.089 1.00 46.09 ? 214 VAL A CG1 1 ATOM 1685 C CG2 . VAL A 1 225 ? 41.984 111.328 -3.097 1.00 45.11 ? 214 VAL A CG2 1 ATOM 1686 N N . ASP A 1 226 ? 43.212 110.215 1.510 1.00 43.02 ? 215 ASP A N 1 ATOM 1687 C CA . ASP A 1 226 ? 43.584 110.279 2.922 1.00 42.63 ? 215 ASP A CA 1 ATOM 1688 C C . ASP A 1 226 ? 45.071 110.001 3.251 1.00 46.56 ? 215 ASP A C 1 ATOM 1689 O O . ASP A 1 226 ? 45.493 108.840 3.383 1.00 47.10 ? 215 ASP A O 1 ATOM 1690 C CB . ASP A 1 226 ? 42.675 109.288 3.671 1.00 43.61 ? 215 ASP A CB 1 ATOM 1691 C CG . ASP A 1 226 ? 42.636 109.388 5.165 1.00 57.22 ? 215 ASP A CG 1 ATOM 1692 O OD1 . ASP A 1 226 ? 43.316 110.275 5.718 1.00 57.79 ? 215 ASP A OD1 1 ATOM 1693 O OD2 . ASP A 1 226 ? 41.872 108.608 5.792 1.00 67.22 ? 215 ASP A OD2 1 ATOM 1694 N N . THR A 1 227 ? 45.818 111.069 3.496 1.00 40.16 ? 216 THR A N 1 ATOM 1695 C CA . THR A 1 227 ? 47.236 111.000 3.864 1.00 38.66 ? 216 THR A CA 1 ATOM 1696 C C . THR A 1 227 ? 47.486 110.309 5.230 1.00 41.70 ? 216 THR A C 1 ATOM 1697 O O . THR A 1 227 ? 48.570 109.745 5.440 1.00 42.29 ? 216 THR A O 1 ATOM 1698 C CB . THR A 1 227 ? 47.841 112.400 3.855 1.00 40.42 ? 216 THR A CB 1 ATOM 1699 O OG1 . THR A 1 227 ? 47.150 113.183 4.828 1.00 37.38 ? 216 THR A OG1 1 ATOM 1700 C CG2 . THR A 1 227 ? 47.770 113.076 2.465 1.00 34.69 ? 216 THR A CG2 1 ATOM 1701 N N . GLY A 1 228 ? 46.497 110.353 6.127 1.00 35.81 ? 217 GLY A N 1 ATOM 1702 C CA . GLY A 1 228 ? 46.590 109.778 7.469 1.00 35.26 ? 217 GLY A CA 1 ATOM 1703 C C . GLY A 1 228 ? 46.245 108.307 7.563 1.00 40.10 ? 217 GLY A C 1 ATOM 1704 O O . GLY A 1 228 ? 46.242 107.737 8.659 1.00 37.46 ? 217 GLY A O 1 ATOM 1705 N N . ALA A 1 229 ? 45.926 107.684 6.426 1.00 38.83 ? 218 ALA A N 1 ATOM 1706 C CA . ALA A 1 229 ? 45.576 106.269 6.372 1.00 38.61 ? 218 ALA A CA 1 ATOM 1707 C C . ALA A 1 229 ? 46.766 105.524 5.802 1.00 41.88 ? 218 ALA A C 1 ATOM 1708 O O . ALA A 1 229 ? 47.462 106.035 4.907 1.00 40.29 ? 218 ALA A O 1 ATOM 1709 C CB . ALA A 1 229 ? 44.343 106.065 5.493 1.00 39.54 ? 218 ALA A CB 1 ATOM 1710 N N . SER A 1 230 ? 47.020 104.333 6.336 1.00 39.23 ? 219 SER A N 1 ATOM 1711 C CA . SER A 1 230 ? 48.144 103.507 5.913 1.00 39.50 ? 219 SER A CA 1 ATOM 1712 C C . SER A 1 230 ? 47.852 102.803 4.622 1.00 46.44 ? 219 SER A C 1 ATOM 1713 O O . SER A 1 230 ? 48.763 102.629 3.814 1.00 48.15 ? 219 SER A O 1 ATOM 1714 C CB . SER A 1 230 ? 48.464 102.449 6.955 1.00 41.10 ? 219 SER A CB 1 ATOM 1715 O OG . SER A 1 230 ? 48.726 103.015 8.220 1.00 46.10 ? 219 SER A OG 1 ATOM 1716 N N . TYR A 1 231 ? 46.614 102.361 4.441 1.00 44.48 ? 220 TYR A N 1 ATOM 1717 C CA . TYR A 1 231 ? 46.239 101.547 3.302 1.00 46.62 ? 220 TYR A CA 1 ATOM 1718 C C . TYR A 1 231 ? 45.237 102.161 2.331 1.00 49.43 ? 220 TYR A C 1 ATOM 1719 O O . TYR A 1 231 ? 44.792 103.296 2.460 1.00 46.38 ? 220 TYR A O 1 ATOM 1720 C CB . TYR A 1 231 ? 45.697 100.193 3.828 1.00 48.97 ? 220 TYR A CB 1 ATOM 1721 C CG . TYR A 1 231 ? 46.560 99.590 4.924 1.00 52.73 ? 220 TYR A CG 1 ATOM 1722 C CD1 . TYR A 1 231 ? 47.905 99.282 4.700 1.00 53.30 ? 220 TYR A CD1 1 ATOM 1723 C CD2 . TYR A 1 231 ? 46.065 99.420 6.213 1.00 55.90 ? 220 TYR A CD2 1 ATOM 1724 C CE1 . TYR A 1 231 ? 48.715 98.764 5.719 1.00 52.17 ? 220 TYR A CE1 1 ATOM 1725 C CE2 . TYR A 1 231 ? 46.881 98.950 7.254 1.00 57.79 ? 220 TYR A CE2 1 ATOM 1726 C CZ . TYR A 1 231 ? 48.201 98.605 6.995 1.00 66.73 ? 220 TYR A CZ 1 ATOM 1727 O OH . TYR A 1 231 ? 49.001 98.117 8.000 1.00 75.10 ? 220 TYR A OH 1 ATOM 1728 N N . ILE A 1 232 ? 44.957 101.390 1.313 1.00 49.13 ? 221 ILE A N 1 ATOM 1729 C CA . ILE A 1 232 ? 43.889 101.630 0.371 1.00 50.08 ? 221 ILE A CA 1 ATOM 1730 C C . ILE A 1 232 ? 42.782 100.797 1.039 1.00 56.33 ? 221 ILE A C 1 ATOM 1731 O O . ILE A 1 232 ? 43.014 99.648 1.439 1.00 56.23 ? 221 ILE A O 1 ATOM 1732 C CB . ILE A 1 232 ? 44.234 101.156 -1.068 1.00 52.71 ? 221 ILE A CB 1 ATOM 1733 C CG1 . ILE A 1 232 ? 45.256 102.126 -1.750 1.00 52.14 ? 221 ILE A CG1 1 ATOM 1734 C CG2 . ILE A 1 232 ? 42.932 100.988 -1.886 1.00 53.78 ? 221 ILE A CG2 1 ATOM 1735 C CD1 . ILE A 1 232 ? 45.875 101.638 -2.985 1.00 56.17 ? 221 ILE A CD1 1 ATOM 1736 N N . SER A 1 233 ? 41.636 101.410 1.275 1.00 54.04 ? 222 SER A N 1 ATOM 1737 C CA . SER A 1 233 ? 40.515 100.723 1.918 1.00 54.18 ? 222 SER A CA 1 ATOM 1738 C C . SER A 1 233 ? 39.213 100.926 1.128 1.00 60.12 ? 222 SER A C 1 ATOM 1739 O O . SER A 1 233 ? 39.051 101.903 0.400 1.00 58.73 ? 222 SER A O 1 ATOM 1740 C CB . SER A 1 233 ? 40.347 101.178 3.367 1.00 54.65 ? 222 SER A CB 1 ATOM 1741 O OG . SER A 1 233 ? 39.737 102.454 3.458 1.00 55.38 ? 222 SER A OG 1 ATOM 1742 N N . GLY A 1 234 ? 38.311 99.981 1.291 1.00 58.81 ? 223 GLY A N 1 ATOM 1743 C CA . GLY A 1 234 ? 36.977 100.006 0.711 1.00 59.54 ? 223 GLY A CA 1 ATOM 1744 C C . GLY A 1 234 ? 36.038 99.385 1.715 1.00 63.53 ? 223 GLY A C 1 ATOM 1745 O O . GLY A 1 234 ? 36.495 98.895 2.756 1.00 62.55 ? 223 GLY A O 1 ATOM 1746 N N . SER A 1 235 ? 34.726 99.390 1.407 1.00 60.13 ? 224 SER A N 1 ATOM 1747 C CA . SER A 1 235 ? 33.675 98.761 2.223 1.00 59.59 ? 224 SER A CA 1 ATOM 1748 C C . SER A 1 235 ? 33.954 97.257 2.359 1.00 64.53 ? 224 SER A C 1 ATOM 1749 O O . SER A 1 235 ? 34.503 96.645 1.427 1.00 63.75 ? 224 SER A O 1 ATOM 1750 C CB . SER A 1 235 ? 32.325 98.920 1.533 1.00 62.11 ? 224 SER A CB 1 ATOM 1751 O OG . SER A 1 235 ? 32.246 98.117 0.360 1.00 66.85 ? 224 SER A OG 1 ATOM 1752 N N . THR A 1 236 ? 33.530 96.664 3.491 1.00 62.37 ? 225 THR A N 1 ATOM 1753 C CA . THR A 1 236 ? 33.633 95.229 3.790 1.00 62.82 ? 225 THR A CA 1 ATOM 1754 C C . THR A 1 236 ? 33.229 94.394 2.571 1.00 68.16 ? 225 THR A C 1 ATOM 1755 O O . THR A 1 236 ? 33.945 93.457 2.214 1.00 68.62 ? 225 THR A O 1 ATOM 1756 C CB . THR A 1 236 ? 32.803 94.901 5.044 1.00 68.20 ? 225 THR A CB 1 ATOM 1757 O OG1 . THR A 1 236 ? 33.378 95.592 6.151 1.00 74.22 ? 225 THR A OG1 1 ATOM 1758 C CG2 . THR A 1 236 ? 32.788 93.426 5.367 1.00 62.55 ? 225 THR A CG2 1 ATOM 1759 N N . SER A 1 237 ? 32.138 94.796 1.894 1.00 63.75 ? 226 SER A N 1 ATOM 1760 C CA . SER A 1 237 ? 31.621 94.133 0.706 1.00 63.42 ? 226 SER A CA 1 ATOM 1761 C C . SER A 1 237 ? 32.616 94.168 -0.458 1.00 65.31 ? 226 SER A C 1 ATOM 1762 O O . SER A 1 237 ? 32.955 93.109 -0.999 1.00 63.43 ? 226 SER A O 1 ATOM 1763 C CB . SER A 1 237 ? 30.292 94.761 0.293 1.00 66.85 ? 226 SER A CB 1 ATOM 1764 O OG . SER A 1 237 ? 29.776 94.101 -0.848 1.00 78.62 ? 226 SER A OG 1 ATOM 1765 N N . SER A 1 238 ? 33.083 95.385 -0.828 1.00 61.92 ? 227 SER A N 1 ATOM 1766 C CA . SER A 1 238 ? 34.035 95.602 -1.932 1.00 61.46 ? 227 SER A CA 1 ATOM 1767 C C . SER A 1 238 ? 35.348 94.836 -1.736 1.00 65.45 ? 227 SER A C 1 ATOM 1768 O O . SER A 1 238 ? 35.806 94.132 -2.651 1.00 64.95 ? 227 SER A O 1 ATOM 1769 C CB . SER A 1 238 ? 34.317 97.085 -2.111 1.00 64.47 ? 227 SER A CB 1 ATOM 1770 O OG . SER A 1 238 ? 33.134 97.792 -2.440 1.00 76.30 ? 227 SER A OG 1 ATOM 1771 N N . ILE A 1 239 ? 35.917 94.934 -0.519 1.00 60.83 ? 228 ILE A N 1 ATOM 1772 C CA . ILE A 1 239 ? 37.166 94.279 -0.152 1.00 60.00 ? 228 ILE A CA 1 ATOM 1773 C C . ILE A 1 239 ? 37.006 92.761 -0.215 1.00 65.36 ? 228 ILE A C 1 ATOM 1774 O O . ILE A 1 239 ? 37.917 92.089 -0.707 1.00 64.52 ? 228 ILE A O 1 ATOM 1775 C CB . ILE A 1 239 ? 37.717 94.834 1.192 1.00 61.93 ? 228 ILE A CB 1 ATOM 1776 C CG1 . ILE A 1 239 ? 38.036 96.347 1.077 1.00 61.75 ? 228 ILE A CG1 1 ATOM 1777 C CG2 . ILE A 1 239 ? 38.928 94.095 1.696 1.00 61.20 ? 228 ILE A CG2 1 ATOM 1778 C CD1 . ILE A 1 239 ? 38.848 96.878 -0.266 1.00 60.23 ? 228 ILE A CD1 1 ATOM 1779 N N . GLU A 1 240 ? 35.821 92.232 0.169 1.00 63.84 ? 229 GLU A N 1 ATOM 1780 C CA . GLU A 1 240 ? 35.538 90.795 0.089 1.00 63.54 ? 229 GLU A CA 1 ATOM 1781 C C . GLU A 1 240 ? 35.612 90.331 -1.357 1.00 67.00 ? 229 GLU A C 1 ATOM 1782 O O . GLU A 1 240 ? 36.297 89.344 -1.634 1.00 67.25 ? 229 GLU A O 1 ATOM 1783 C CB . GLU A 1 240 ? 34.167 90.470 0.671 1.00 65.08 ? 229 GLU A CB 1 ATOM 1784 C CG . GLU A 1 240 ? 34.202 90.206 2.163 1.00 81.12 ? 229 GLU A CG 1 ATOM 1785 C CD . GLU A 1 240 ? 32.850 90.102 2.849 1.00 105.89 ? 229 GLU A CD 1 ATOM 1786 O OE1 . GLU A 1 240 ? 32.845 90.073 4.101 1.00 97.29 ? 229 GLU A OE1 1 ATOM 1787 O OE2 . GLU A 1 240 ? 31.805 90.041 2.153 1.00 95.61 ? 229 GLU A OE2 1 ATOM 1788 N N . LYS A 1 241 ? 34.951 91.060 -2.284 1.00 62.40 ? 230 LYS A N 1 ATOM 1789 C CA . LYS A 1 241 ? 34.968 90.698 -3.701 1.00 63.03 ? 230 LYS A CA 1 ATOM 1790 C C . LYS A 1 241 ? 36.410 90.751 -4.204 1.00 69.40 ? 230 LYS A C 1 ATOM 1791 O O . LYS A 1 241 ? 36.907 89.741 -4.710 1.00 71.84 ? 230 LYS A O 1 ATOM 1792 C CB . LYS A 1 241 ? 34.035 91.601 -4.549 1.00 65.66 ? 230 LYS A CB 1 ATOM 1793 C CG . LYS A 1 241 ? 32.577 91.650 -4.082 1.00 78.02 ? 230 LYS A CG 1 ATOM 1794 C CD . LYS A 1 241 ? 31.684 92.450 -5.032 1.00 91.11 ? 230 LYS A CD 1 ATOM 1795 C CE . LYS A 1 241 ? 30.653 93.296 -4.312 1.00 104.30 ? 230 LYS A CE 1 ATOM 1796 N NZ . LYS A 1 241 ? 30.474 94.633 -4.957 1.00 112.91 ? 230 LYS A NZ 1 ATOM 1797 N N . LEU A 1 242 ? 37.107 91.893 -3.954 1.00 63.27 ? 231 LEU A N 1 ATOM 1798 C CA . LEU A 1 242 ? 38.499 92.152 -4.319 1.00 60.65 ? 231 LEU A CA 1 ATOM 1799 C C . LEU A 1 242 ? 39.432 91.030 -3.889 1.00 61.98 ? 231 LEU A C 1 ATOM 1800 O O . LEU A 1 242 ? 40.201 90.539 -4.715 1.00 61.67 ? 231 LEU A O 1 ATOM 1801 C CB . LEU A 1 242 ? 38.964 93.483 -3.705 1.00 60.27 ? 231 LEU A CB 1 ATOM 1802 C CG . LEU A 1 242 ? 40.389 93.924 -4.035 1.00 64.27 ? 231 LEU A CG 1 ATOM 1803 C CD1 . LEU A 1 242 ? 40.424 94.817 -5.226 1.00 64.60 ? 231 LEU A CD1 1 ATOM 1804 C CD2 . LEU A 1 242 ? 40.979 94.673 -2.918 1.00 66.91 ? 231 LEU A CD2 1 ATOM 1805 N N . MET A 1 243 ? 39.374 90.634 -2.606 1.00 56.33 ? 232 MET A N 1 ATOM 1806 C CA . MET A 1 243 ? 40.255 89.600 -2.057 1.00 56.03 ? 232 MET A CA 1 ATOM 1807 C C . MET A 1 243 ? 39.998 88.221 -2.631 1.00 63.71 ? 232 MET A C 1 ATOM 1808 O O . MET A 1 243 ? 40.945 87.494 -2.943 1.00 64.24 ? 232 MET A O 1 ATOM 1809 C CB . MET A 1 243 ? 40.204 89.586 -0.534 1.00 57.73 ? 232 MET A CB 1 ATOM 1810 C CG . MET A 1 243 ? 40.708 90.862 0.075 1.00 60.05 ? 232 MET A CG 1 ATOM 1811 S SD . MET A 1 243 ? 42.472 91.156 -0.198 1.00 62.56 ? 232 MET A SD 1 ATOM 1812 C CE . MET A 1 243 ? 42.537 92.921 0.155 1.00 59.20 ? 232 MET A CE 1 ATOM 1813 N N . GLU A 1 244 ? 38.713 87.878 -2.810 1.00 62.57 ? 233 GLU A N 1 ATOM 1814 C CA . GLU A 1 244 ? 38.262 86.627 -3.405 1.00 63.23 ? 233 GLU A CA 1 ATOM 1815 C C . GLU A 1 244 ? 38.889 86.522 -4.793 1.00 66.48 ? 233 GLU A C 1 ATOM 1816 O O . GLU A 1 244 ? 39.413 85.469 -5.134 1.00 66.71 ? 233 GLU A O 1 ATOM 1817 C CB . GLU A 1 244 ? 36.729 86.598 -3.466 1.00 65.22 ? 233 GLU A CB 1 ATOM 1818 C CG . GLU A 1 244 ? 36.152 85.215 -3.221 1.00 83.18 ? 233 GLU A CG 1 ATOM 1819 C CD . GLU A 1 244 ? 35.719 84.479 -4.467 1.00 115.62 ? 233 GLU A CD 1 ATOM 1820 O OE1 . GLU A 1 244 ? 34.503 84.508 -4.772 1.00 118.41 ? 233 GLU A OE1 1 ATOM 1821 O OE2 . GLU A 1 244 ? 36.572 83.800 -5.085 1.00 112.19 ? 233 GLU A OE2 1 ATOM 1822 N N . ALA A 1 245 ? 38.940 87.648 -5.531 1.00 62.49 ? 234 ALA A N 1 ATOM 1823 C CA . ALA A 1 245 ? 39.567 87.739 -6.842 1.00 63.33 ? 234 ALA A CA 1 ATOM 1824 C C . ALA A 1 245 ? 41.090 87.572 -6.765 1.00 68.20 ? 234 ALA A C 1 ATOM 1825 O O . ALA A 1 245 ? 41.685 86.985 -7.672 1.00 69.55 ? 234 ALA A O 1 ATOM 1826 C CB . ALA A 1 245 ? 39.213 89.066 -7.500 1.00 64.38 ? 234 ALA A CB 1 ATOM 1827 N N . LEU A 1 246 ? 41.717 88.067 -5.685 1.00 63.75 ? 235 LEU A N 1 ATOM 1828 C CA . LEU A 1 246 ? 43.165 87.980 -5.499 1.00 62.42 ? 235 LEU A CA 1 ATOM 1829 C C . LEU A 1 246 ? 43.657 86.610 -5.042 1.00 69.20 ? 235 LEU A C 1 ATOM 1830 O O . LEU A 1 246 ? 44.807 86.247 -5.342 1.00 70.99 ? 235 LEU A O 1 ATOM 1831 C CB . LEU A 1 246 ? 43.685 89.076 -4.557 1.00 61.18 ? 235 LEU A CB 1 ATOM 1832 C CG . LEU A 1 246 ? 43.518 90.527 -5.027 1.00 64.29 ? 235 LEU A CG 1 ATOM 1833 C CD1 . LEU A 1 246 ? 44.014 91.481 -3.984 1.00 63.73 ? 235 LEU A CD1 1 ATOM 1834 C CD2 . LEU A 1 246 ? 44.201 90.792 -6.372 1.00 65.42 ? 235 LEU A CD2 1 ATOM 1835 N N . GLY A 1 247 ? 42.802 85.870 -4.330 1.00 64.51 ? 236 GLY A N 1 ATOM 1836 C CA . GLY A 1 247 ? 43.150 84.562 -3.786 1.00 63.69 ? 236 GLY A CA 1 ATOM 1837 C C . GLY A 1 247 ? 43.659 84.701 -2.371 1.00 69.09 ? 236 GLY A C 1 ATOM 1838 O O . GLY A 1 247 ? 44.270 83.779 -1.816 1.00 68.65 ? 236 GLY A O 1 ATOM 1839 N N . ALA A 1 248 ? 43.412 85.892 -1.789 1.00 67.87 ? 237 ALA A N 1 ATOM 1840 C CA . ALA A 1 248 ? 43.810 86.277 -0.431 1.00 68.12 ? 237 ALA A CA 1 ATOM 1841 C C . ALA A 1 248 ? 42.784 85.810 0.592 1.00 70.52 ? 237 ALA A C 1 ATOM 1842 O O . ALA A 1 248 ? 41.574 85.844 0.324 1.00 71.14 ? 237 ALA A O 1 ATOM 1843 C CB . ALA A 1 248 ? 43.995 87.787 -0.342 1.00 68.96 ? 237 ALA A CB 1 ATOM 1844 N N . LYS A 1 249 ? 43.278 85.393 1.762 1.00 64.71 ? 238 LYS A N 1 ATOM 1845 C CA . LYS A 1 249 ? 42.472 84.893 2.867 1.00 64.51 ? 238 LYS A CA 1 ATOM 1846 C C . LYS A 1 249 ? 42.421 85.898 4.005 1.00 67.85 ? 238 LYS A C 1 ATOM 1847 O O . LYS A 1 249 ? 43.430 86.542 4.310 1.00 67.10 ? 238 LYS A O 1 ATOM 1848 C CB . LYS A 1 249 ? 43.012 83.540 3.375 1.00 67.96 ? 238 LYS A CB 1 ATOM 1849 C CG . LYS A 1 249 ? 43.286 82.508 2.271 1.00 92.92 ? 238 LYS A CG 1 ATOM 1850 C CD . LYS A 1 249 ? 42.057 81.694 1.810 1.00 99.95 ? 238 LYS A CD 1 ATOM 1851 C CE . LYS A 1 249 ? 42.413 80.784 0.654 1.00 100.18 ? 238 LYS A CE 1 ATOM 1852 N NZ . LYS A 1 249 ? 43.361 79.699 1.051 1.00 100.07 ? 238 LYS A NZ 1 ATOM 1853 N N . LYS A 1 250 ? 41.207 86.054 4.593 1.00 62.88 ? 239 LYS A N 1 ATOM 1854 C CA . LYS A 1 250 ? 40.869 86.982 5.673 1.00 61.20 ? 239 LYS A CA 1 ATOM 1855 C C . LYS A 1 250 ? 41.295 86.514 7.045 1.00 61.24 ? 239 LYS A C 1 ATOM 1856 O O . LYS A 1 250 ? 40.815 85.493 7.531 1.00 60.70 ? 239 LYS A O 1 ATOM 1857 C CB . LYS A 1 250 ? 39.353 87.307 5.663 1.00 63.47 ? 239 LYS A CB 1 ATOM 1858 C CG . LYS A 1 250 ? 38.961 88.493 6.543 1.00 76.23 ? 239 LYS A CG 1 ATOM 1859 C CD . LYS A 1 250 ? 37.539 88.382 7.064 1.00 87.59 ? 239 LYS A CD 1 ATOM 1860 C CE . LYS A 1 250 ? 37.472 87.883 8.501 1.00 101.39 ? 239 LYS A CE 1 ATOM 1861 N NZ . LYS A 1 250 ? 37.814 88.943 9.495 1.00 107.23 ? 239 LYS A NZ 1 ATOM 1862 N N . ARG A 1 251 ? 42.153 87.307 7.687 1.00 56.15 ? 240 ARG A N 1 ATOM 1863 C CA . ARG A 1 251 ? 42.633 87.125 9.058 1.00 55.18 ? 240 ARG A CA 1 ATOM 1864 C C . ARG A 1 251 ? 41.792 88.092 9.926 1.00 62.13 ? 240 ARG A C 1 ATOM 1865 O O . ARG A 1 251 ? 40.802 88.656 9.416 1.00 62.14 ? 240 ARG A O 1 ATOM 1866 C CB . ARG A 1 251 ? 44.123 87.460 9.128 1.00 50.97 ? 240 ARG A CB 1 ATOM 1867 C CG . ARG A 1 251 ? 44.992 86.293 9.520 1.00 56.41 ? 240 ARG A CG 1 ATOM 1868 C CD . ARG A 1 251 ? 46.331 86.284 8.819 1.00 59.53 ? 240 ARG A CD 1 ATOM 1869 N NE . ARG A 1 251 ? 47.149 87.476 9.062 1.00 60.82 ? 240 ARG A NE 1 ATOM 1870 C CZ . ARG A 1 251 ? 48.407 87.457 9.504 1.00 73.84 ? 240 ARG A CZ 1 ATOM 1871 N NH1 . ARG A 1 251 ? 48.999 86.303 9.803 1.00 56.62 ? 240 ARG A NH1 1 ATOM 1872 N NH2 . ARG A 1 251 ? 49.080 88.592 9.657 1.00 56.94 ? 240 ARG A NH2 1 ATOM 1873 N N . LEU A 1 252 ? 42.166 88.300 11.211 1.00 59.56 ? 241 LEU A N 1 ATOM 1874 C CA . LEU A 1 252 ? 41.389 89.172 12.108 1.00 59.74 ? 241 LEU A CA 1 ATOM 1875 C C . LEU A 1 252 ? 41.394 90.683 11.766 1.00 66.26 ? 241 LEU A C 1 ATOM 1876 O O . LEU A 1 252 ? 40.342 91.318 11.852 1.00 66.90 ? 241 LEU A O 1 ATOM 1877 C CB . LEU A 1 252 ? 41.837 88.962 13.552 1.00 59.33 ? 241 LEU A CB 1 ATOM 1878 C CG . LEU A 1 252 ? 40.954 89.519 14.660 1.00 62.33 ? 241 LEU A CG 1 ATOM 1879 C CD1 . LEU A 1 252 ? 39.560 88.918 14.614 1.00 61.12 ? 241 LEU A CD1 1 ATOM 1880 C CD2 . LEU A 1 252 ? 41.596 89.248 16.007 1.00 64.20 ? 241 LEU A CD2 1 ATOM 1881 N N . PHE A 1 253 ? 42.556 91.256 11.401 1.00 63.36 ? 242 PHE A N 1 ATOM 1882 C CA . PHE A 1 253 ? 42.652 92.686 11.081 1.00 62.64 ? 242 PHE A CA 1 ATOM 1883 C C . PHE A 1 253 ? 43.213 92.988 9.685 1.00 65.66 ? 242 PHE A C 1 ATOM 1884 O O . PHE A 1 253 ? 43.270 94.153 9.280 1.00 65.51 ? 242 PHE A O 1 ATOM 1885 C CB . PHE A 1 253 ? 43.446 93.417 12.166 1.00 64.02 ? 242 PHE A CB 1 ATOM 1886 C CG . PHE A 1 253 ? 42.783 93.327 13.519 1.00 65.13 ? 242 PHE A CG 1 ATOM 1887 C CD1 . PHE A 1 253 ? 41.536 93.898 13.738 1.00 68.51 ? 242 PHE A CD1 1 ATOM 1888 C CD2 . PHE A 1 253 ? 43.411 92.676 14.576 1.00 66.43 ? 242 PHE A CD2 1 ATOM 1889 C CE1 . PHE A 1 253 ? 40.918 93.800 14.988 1.00 70.02 ? 242 PHE A CE1 1 ATOM 1890 C CE2 . PHE A 1 253 ? 42.803 92.592 15.827 1.00 69.24 ? 242 PHE A CE2 1 ATOM 1891 C CZ . PHE A 1 253 ? 41.557 93.141 16.021 1.00 68.35 ? 242 PHE A CZ 1 ATOM 1892 N N . ASP A 1 254 ? 43.588 91.940 8.944 1.00 61.08 ? 244 ASP A N 1 ATOM 1893 C CA . ASP A 1 254 ? 44.141 92.052 7.601 1.00 60.21 ? 244 ASP A CA 1 ATOM 1894 C C . ASP A 1 254 ? 43.757 90.830 6.754 1.00 63.80 ? 244 ASP A C 1 ATOM 1895 O O . ASP A 1 254 ? 43.018 89.966 7.217 1.00 63.10 ? 244 ASP A O 1 ATOM 1896 C CB . ASP A 1 254 ? 45.685 92.238 7.664 1.00 61.25 ? 244 ASP A CB 1 ATOM 1897 C CG . ASP A 1 254 ? 46.501 91.091 8.255 1.00 63.40 ? 244 ASP A CG 1 ATOM 1898 O OD1 . ASP A 1 254 ? 45.995 89.961 8.304 1.00 60.17 ? 244 ASP A OD1 1 ATOM 1899 O OD2 . ASP A 1 254 ? 47.654 91.329 8.647 1.00 72.80 ? 244 ASP A OD2 1 ATOM 1900 N N . TYR A 1 255 ? 44.247 90.803 5.505 1.00 59.68 ? 245 TYR A N 1 ATOM 1901 C CA . TYR A 1 255 ? 44.151 89.775 4.500 1.00 58.64 ? 245 TYR A CA 1 ATOM 1902 C C . TYR A 1 255 ? 45.566 89.399 4.118 1.00 60.06 ? 245 TYR A C 1 ATOM 1903 O O . TYR A 1 255 ? 46.434 90.255 4.012 1.00 58.88 ? 245 TYR A O 1 ATOM 1904 C CB . TYR A 1 255 ? 43.421 90.331 3.288 1.00 60.13 ? 245 TYR A CB 1 ATOM 1905 C CG . TYR A 1 255 ? 41.913 90.265 3.394 1.00 62.80 ? 245 TYR A CG 1 ATOM 1906 C CD1 . TYR A 1 255 ? 41.211 89.143 2.959 1.00 64.59 ? 245 TYR A CD1 1 ATOM 1907 C CD2 . TYR A 1 255 ? 41.178 91.354 3.851 1.00 63.72 ? 245 TYR A CD2 1 ATOM 1908 C CE1 . TYR A 1 255 ? 39.816 89.107 2.977 1.00 65.13 ? 245 TYR A CE1 1 ATOM 1909 C CE2 . TYR A 1 255 ? 39.785 91.320 3.890 1.00 64.70 ? 245 TYR A CE2 1 ATOM 1910 C CZ . TYR A 1 255 ? 39.105 90.196 3.443 1.00 74.76 ? 245 TYR A CZ 1 ATOM 1911 O OH . TYR A 1 255 ? 37.722 90.139 3.477 1.00 79.64 ? 245 TYR A OH 1 ATOM 1912 N N . VAL A 1 256 ? 45.803 88.111 3.923 1.00 56.16 ? 246 VAL A N 1 ATOM 1913 C CA . VAL A 1 256 ? 47.116 87.615 3.552 1.00 54.67 ? 246 VAL A CA 1 ATOM 1914 C C . VAL A 1 256 ? 47.067 86.702 2.348 1.00 57.59 ? 246 VAL A C 1 ATOM 1915 O O . VAL A 1 256 ? 46.023 86.152 2.008 1.00 58.69 ? 246 VAL A O 1 ATOM 1916 C CB . VAL A 1 256 ? 47.842 86.907 4.722 1.00 57.44 ? 246 VAL A CB 1 ATOM 1917 C CG1 . VAL A 1 256 ? 48.203 87.883 5.840 1.00 56.79 ? 246 VAL A CG1 1 ATOM 1918 C CG2 . VAL A 1 256 ? 47.042 85.719 5.236 1.00 57.06 ? 246 VAL A CG2 1 ATOM 1919 N N . VAL A 1 257 ? 48.221 86.515 1.730 1.00 51.03 ? 247 VAL A N 1 ATOM 1920 C CA . VAL A 1 257 ? 48.433 85.539 0.690 1.00 49.58 ? 247 VAL A CA 1 ATOM 1921 C C . VAL A 1 257 ? 49.636 84.794 1.188 1.00 54.91 ? 247 VAL A C 1 ATOM 1922 O O . VAL A 1 257 ? 50.336 85.288 2.073 1.00 56.11 ? 247 VAL A O 1 ATOM 1923 C CB . VAL A 1 257 ? 48.674 86.119 -0.725 1.00 52.67 ? 247 VAL A CB 1 ATOM 1924 C CG1 . VAL A 1 257 ? 47.435 86.814 -1.269 1.00 52.02 ? 247 VAL A CG1 1 ATOM 1925 C CG2 . VAL A 1 257 ? 49.892 87.039 -0.768 1.00 53.12 ? 247 VAL A CG2 1 ATOM 1926 N N . LYS A 1 258 ? 49.890 83.621 0.627 1.00 52.15 ? 248 LYS A N 1 ATOM 1927 C CA . LYS A 1 258 ? 51.096 82.845 0.883 1.00 52.27 ? 248 LYS A CA 1 ATOM 1928 C C . LYS A 1 258 ? 52.198 83.677 0.220 1.00 55.17 ? 248 LYS A C 1 ATOM 1929 O O . LYS A 1 258 ? 51.981 84.166 -0.889 1.00 55.21 ? 248 LYS A O 1 ATOM 1930 C CB . LYS A 1 258 ? 50.980 81.494 0.181 1.00 55.91 ? 248 LYS A CB 1 ATOM 1931 C CG . LYS A 1 258 ? 49.969 80.514 0.770 1.00 86.60 ? 248 LYS A CG 1 ATOM 1932 C CD . LYS A 1 258 ? 50.469 79.060 0.626 1.00 106.50 ? 248 LYS A CD 1 ATOM 1933 C CE . LYS A 1 258 ? 50.378 78.470 -0.774 1.00 124.11 ? 248 LYS A CE 1 ATOM 1934 N NZ . LYS A 1 258 ? 49.006 77.982 -1.094 1.00 137.07 ? 248 LYS A NZ 1 ATOM 1935 N N . CYS A 1 259 ? 53.315 83.932 0.903 1.00 51.91 ? 249 CYS A N 1 ATOM 1936 C CA . CYS A 1 259 ? 54.381 84.815 0.369 1.00 52.17 ? 249 CYS A CA 1 ATOM 1937 C C . CYS A 1 259 ? 54.851 84.466 -1.066 1.00 55.97 ? 249 CYS A C 1 ATOM 1938 O O . CYS A 1 259 ? 55.045 85.365 -1.891 1.00 54.27 ? 249 CYS A O 1 ATOM 1939 C CB . CYS A 1 259 ? 55.553 84.914 1.338 1.00 51.99 ? 249 CYS A CB 1 ATOM 1940 S SG . CYS A 1 259 ? 55.164 85.827 2.859 1.00 55.80 ? 249 CYS A SG 1 ATOM 1941 N N . ASN A 1 260 ? 54.966 83.171 -1.360 1.00 54.41 ? 250 ASN A N 1 ATOM 1942 C CA . ASN A 1 260 ? 55.340 82.672 -2.681 1.00 54.91 ? 250 ASN A CA 1 ATOM 1943 C C . ASN A 1 260 ? 54.337 83.109 -3.778 1.00 57.71 ? 250 ASN A C 1 ATOM 1944 O O . ASN A 1 260 ? 54.736 83.177 -4.929 1.00 57.56 ? 250 ASN A O 1 ATOM 1945 C CB . ASN A 1 260 ? 55.490 81.138 -2.654 1.00 56.11 ? 250 ASN A CB 1 ATOM 1946 C CG . ASN A 1 260 ? 54.175 80.385 -2.772 1.00 75.30 ? 250 ASN A CG 1 ATOM 1947 O OD1 . ASN A 1 260 ? 53.806 79.894 -3.839 1.00 67.41 ? 250 ASN A OD1 1 ATOM 1948 N ND2 . ASN A 1 260 ? 53.415 80.318 -1.700 1.00 64.59 ? 250 ASN A ND2 1 ATOM 1949 N N . GLU A 1 261 ? 53.058 83.400 -3.432 1.00 53.71 ? 251 GLU A N 1 ATOM 1950 C CA . GLU A 1 261 ? 52.078 83.795 -4.444 1.00 53.84 ? 251 GLU A CA 1 ATOM 1951 C C . GLU A 1 261 ? 51.935 85.342 -4.597 1.00 57.59 ? 251 GLU A C 1 ATOM 1952 O O . GLU A 1 261 ? 51.175 85.807 -5.444 1.00 58.58 ? 251 GLU A O 1 ATOM 1953 C CB . GLU A 1 261 ? 50.717 83.074 -4.244 1.00 55.88 ? 251 GLU A CB 1 ATOM 1954 C CG . GLU A 1 261 ? 49.991 83.328 -2.928 1.00 74.84 ? 251 GLU A CG 1 ATOM 1955 C CD . GLU A 1 261 ? 48.895 82.357 -2.499 1.00 106.31 ? 251 GLU A CD 1 ATOM 1956 O OE1 . GLU A 1 261 ? 49.089 81.128 -2.657 1.00 106.29 ? 251 GLU A OE1 1 ATOM 1957 O OE2 . GLU A 1 261 ? 47.892 82.820 -1.902 1.00 94.94 ? 251 GLU A OE2 1 ATOM 1958 N N . GLY A 1 262 ? 52.739 86.109 -3.865 1.00 53.16 ? 252 GLY A N 1 ATOM 1959 C CA . GLY A 1 262 ? 52.728 87.566 -3.905 1.00 52.21 ? 252 GLY A CA 1 ATOM 1960 C C . GLY A 1 262 ? 53.099 88.191 -5.240 1.00 55.83 ? 252 GLY A C 1 ATOM 1961 O O . GLY A 1 262 ? 52.338 89.002 -5.765 1.00 54.19 ? 252 GLY A O 1 ATOM 1962 N N . PRO A 1 263 ? 54.280 87.865 -5.814 1.00 53.95 ? 253 PRO A N 1 ATOM 1963 C CA . PRO A 1 263 ? 54.689 88.507 -7.092 1.00 54.06 ? 253 PRO A CA 1 ATOM 1964 C C . PRO A 1 263 ? 53.783 88.249 -8.308 1.00 62.58 ? 253 PRO A C 1 ATOM 1965 O O . PRO A 1 263 ? 53.720 89.056 -9.244 1.00 62.63 ? 253 PRO A O 1 ATOM 1966 C CB . PRO A 1 263 ? 56.087 87.939 -7.326 1.00 54.83 ? 253 PRO A CB 1 ATOM 1967 C CG . PRO A 1 263 ? 56.562 87.434 -5.966 1.00 58.32 ? 253 PRO A CG 1 ATOM 1968 C CD . PRO A 1 263 ? 55.335 86.956 -5.289 1.00 54.38 ? 253 PRO A CD 1 ATOM 1969 N N . THR A 1 264 ? 53.087 87.114 -8.273 1.00 60.93 ? 254 THR A N 1 ATOM 1970 C CA . THR A 1 264 ? 52.174 86.590 -9.283 1.00 60.60 ? 254 THR A CA 1 ATOM 1971 C C . THR A 1 264 ? 50.797 87.309 -9.296 1.00 63.28 ? 254 THR A C 1 ATOM 1972 O O . THR A 1 264 ? 50.036 87.100 -10.230 1.00 63.43 ? 254 THR A O 1 ATOM 1973 C CB . THR A 1 264 ? 51.983 85.089 -9.009 1.00 69.58 ? 254 THR A CB 1 ATOM 1974 O OG1 . THR A 1 264 ? 50.719 84.901 -8.366 1.00 72.84 ? 254 THR A OG1 1 ATOM 1975 C CG2 . THR A 1 264 ? 53.131 84.459 -8.163 1.00 65.24 ? 254 THR A CG2 1 ATOM 1976 N N . LEU A 1 265 ? 50.455 88.088 -8.250 1.00 58.66 ? 255 LEU A N 1 ATOM 1977 C CA . LEU A 1 265 ? 49.158 88.765 -8.113 1.00 57.72 ? 255 LEU A CA 1 ATOM 1978 C C . LEU A 1 265 ? 48.923 89.849 -9.154 1.00 60.30 ? 255 LEU A C 1 ATOM 1979 O O . LEU A 1 265 ? 49.894 90.476 -9.597 1.00 58.45 ? 255 LEU A O 1 ATOM 1980 C CB . LEU A 1 265 ? 48.942 89.315 -6.697 1.00 58.14 ? 255 LEU A CB 1 ATOM 1981 C CG . LEU A 1 265 ? 48.979 88.316 -5.535 1.00 63.51 ? 255 LEU A CG 1 ATOM 1982 C CD1 . LEU A 1 265 ? 48.538 88.991 -4.264 1.00 63.96 ? 255 LEU A CD1 1 ATOM 1983 C CD2 . LEU A 1 265 ? 48.112 87.073 -5.802 1.00 64.96 ? 255 LEU A CD2 1 ATOM 1984 N N . PRO A 1 266 ? 47.643 90.068 -9.584 1.00 57.12 ? 256 PRO A N 1 ATOM 1985 C CA . PRO A 1 266 ? 47.385 91.035 -10.670 1.00 56.37 ? 256 PRO A CA 1 ATOM 1986 C C . PRO A 1 266 ? 47.442 92.497 -10.291 1.00 59.45 ? 256 PRO A C 1 ATOM 1987 O O . PRO A 1 266 ? 47.328 92.845 -9.123 1.00 61.04 ? 256 PRO A O 1 ATOM 1988 C CB . PRO A 1 266 ? 45.984 90.655 -11.157 1.00 57.83 ? 256 PRO A CB 1 ATOM 1989 C CG . PRO A 1 266 ? 45.322 90.127 -9.962 1.00 62.30 ? 256 PRO A CG 1 ATOM 1990 C CD . PRO A 1 266 ? 46.391 89.383 -9.188 1.00 58.42 ? 256 PRO A CD 1 ATOM 1991 N N . ASP A 1 267 ? 47.561 93.352 -11.306 1.00 53.66 ? 257 ASP A N 1 ATOM 1992 C CA . ASP A 1 267 ? 47.557 94.795 -11.160 1.00 52.90 ? 257 ASP A CA 1 ATOM 1993 C C . ASP A 1 267 ? 46.183 95.244 -10.663 1.00 56.04 ? 257 ASP A C 1 ATOM 1994 O O . ASP A 1 267 ? 45.175 94.659 -11.054 1.00 56.18 ? 257 ASP A O 1 ATOM 1995 C CB . ASP A 1 267 ? 47.853 95.456 -12.528 1.00 54.52 ? 257 ASP A CB 1 ATOM 1996 C CG . ASP A 1 267 ? 49.268 95.293 -13.073 1.00 63.00 ? 257 ASP A CG 1 ATOM 1997 O OD1 . ASP A 1 267 ? 50.100 94.646 -12.398 1.00 63.31 ? 257 ASP A OD1 1 ATOM 1998 O OD2 . ASP A 1 267 ? 49.546 95.827 -14.164 1.00 68.90 ? 257 ASP A OD2 1 ATOM 1999 N N . ILE A 1 268 ? 46.142 96.254 -9.791 1.00 51.15 ? 258 ILE A N 1 ATOM 2000 C CA . ILE A 1 268 ? 44.883 96.826 -9.320 1.00 50.06 ? 258 ILE A CA 1 ATOM 2001 C C . ILE A 1 268 ? 44.834 98.262 -9.840 1.00 52.57 ? 258 ILE A C 1 ATOM 2002 O O . ILE A 1 268 ? 45.755 99.044 -9.594 1.00 51.15 ? 258 ILE A O 1 ATOM 2003 C CB . ILE A 1 268 ? 44.645 96.705 -7.787 1.00 53.20 ? 258 ILE A CB 1 ATOM 2004 C CG1 . ILE A 1 268 ? 44.630 95.211 -7.340 1.00 53.68 ? 258 ILE A CG1 1 ATOM 2005 C CG2 . ILE A 1 268 ? 43.338 97.424 -7.393 1.00 53.38 ? 258 ILE A CG2 1 ATOM 2006 C CD1 . ILE A 1 268 ? 44.553 94.954 -5.861 1.00 58.66 ? 258 ILE A CD1 1 ATOM 2007 N N . SER A 1 269 ? 43.774 98.586 -10.592 1.00 49.68 ? 259 SER A N 1 ATOM 2008 C CA . SER A 1 269 ? 43.608 99.898 -11.189 1.00 49.61 ? 259 SER A CA 1 ATOM 2009 C C . SER A 1 269 ? 42.443 100.650 -10.638 1.00 53.75 ? 259 SER A C 1 ATOM 2010 O O . SER A 1 269 ? 41.489 100.048 -10.155 1.00 53.31 ? 259 SER A O 1 ATOM 2011 C CB . SER A 1 269 ? 43.545 99.800 -12.705 1.00 54.32 ? 259 SER A CB 1 ATOM 2012 O OG . SER A 1 269 ? 44.818 99.406 -13.186 1.00 62.49 ? 259 SER A OG 1 ATOM 2013 N N . PHE A 1 270 ? 42.547 101.982 -10.681 1.00 51.29 ? 260 PHE A N 1 ATOM 2014 C CA . PHE A 1 270 ? 41.568 102.899 -10.130 1.00 51.61 ? 260 PHE A CA 1 ATOM 2015 C C . PHE A 1 270 ? 41.311 103.997 -11.130 1.00 58.61 ? 260 PHE A C 1 ATOM 2016 O O . PHE A 1 270 ? 42.186 104.835 -11.384 1.00 56.75 ? 260 PHE A O 1 ATOM 2017 C CB . PHE A 1 270 ? 42.063 103.480 -8.768 1.00 53.03 ? 260 PHE A CB 1 ATOM 2018 C CG . PHE A 1 270 ? 42.468 102.473 -7.698 1.00 53.01 ? 260 PHE A CG 1 ATOM 2019 C CD1 . PHE A 1 270 ? 43.773 101.990 -7.630 1.00 54.23 ? 260 PHE A CD1 1 ATOM 2020 C CD2 . PHE A 1 270 ? 41.548 102.036 -6.744 1.00 53.65 ? 260 PHE A CD2 1 ATOM 2021 C CE1 . PHE A 1 270 ? 44.137 101.045 -6.662 1.00 55.52 ? 260 PHE A CE1 1 ATOM 2022 C CE2 . PHE A 1 270 ? 41.914 101.105 -5.764 1.00 56.36 ? 260 PHE A CE2 1 ATOM 2023 C CZ . PHE A 1 270 ? 43.204 100.612 -5.727 1.00 54.91 ? 260 PHE A CZ 1 ATOM 2024 N N . HIS A 1 271 ? 40.115 103.969 -11.740 1.00 60.35 ? 261 HIS A N 1 ATOM 2025 C CA . HIS A 1 271 ? 39.765 104.994 -12.707 1.00 62.73 ? 261 HIS A CA 1 ATOM 2026 C C . HIS A 1 271 ? 39.297 106.246 -11.958 1.00 63.21 ? 261 HIS A C 1 ATOM 2027 O O . HIS A 1 271 ? 38.267 106.200 -11.275 1.00 61.63 ? 261 HIS A O 1 ATOM 2028 C CB . HIS A 1 271 ? 38.791 104.496 -13.818 1.00 65.27 ? 261 HIS A CB 1 ATOM 2029 C CG . HIS A 1 271 ? 38.615 105.474 -14.965 1.00 70.19 ? 261 HIS A CG 1 ATOM 2030 N ND1 . HIS A 1 271 ? 37.420 105.555 -15.674 1.00 72.77 ? 261 HIS A ND1 1 ATOM 2031 C CD2 . HIS A 1 271 ? 39.465 106.421 -15.447 1.00 72.94 ? 261 HIS A CD2 1 ATOM 2032 C CE1 . HIS A 1 271 ? 37.583 106.543 -16.553 1.00 72.59 ? 261 HIS A CE1 1 ATOM 2033 N NE2 . HIS A 1 271 ? 38.793 107.100 -16.449 1.00 72.94 ? 261 HIS A NE2 1 ATOM 2034 N N . LEU A 1 272 ? 40.138 107.318 -12.017 1.00 57.49 ? 262 LEU A N 1 ATOM 2035 C CA . LEU A 1 272 ? 39.943 108.621 -11.368 1.00 57.00 ? 262 LEU A CA 1 ATOM 2036 C C . LEU A 1 272 ? 40.145 109.680 -12.408 1.00 62.84 ? 262 LEU A C 1 ATOM 2037 O O . LEU A 1 272 ? 41.241 109.775 -12.977 1.00 63.51 ? 262 LEU A O 1 ATOM 2038 C CB . LEU A 1 272 ? 40.986 108.862 -10.244 1.00 56.81 ? 262 LEU A CB 1 ATOM 2039 C CG . LEU A 1 272 ? 41.194 107.782 -9.185 1.00 60.02 ? 262 LEU A CG 1 ATOM 2040 C CD1 . LEU A 1 272 ? 42.491 108.018 -8.449 1.00 59.19 ? 262 LEU A CD1 1 ATOM 2041 C CD2 . LEU A 1 272 ? 39.988 107.667 -8.251 1.00 58.95 ? 262 LEU A CD2 1 ATOM 2042 N N . GLY A 1 273 ? 39.116 110.493 -12.630 1.00 60.10 ? 263 GLY A N 1 ATOM 2043 C CA . GLY A 1 273 ? 39.148 111.511 -13.673 1.00 59.83 ? 263 GLY A CA 1 ATOM 2044 C C . GLY A 1 273 ? 39.304 110.829 -15.027 1.00 65.07 ? 263 GLY A C 1 ATOM 2045 O O . GLY A 1 273 ? 38.728 109.758 -15.285 1.00 64.46 ? 263 GLY A O 1 ATOM 2046 N N . GLY A 1 274 ? 40.144 111.400 -15.862 1.00 62.83 ? 264 GLY A N 1 ATOM 2047 C CA . GLY A 1 274 ? 40.411 110.813 -17.163 1.00 63.92 ? 264 GLY A CA 1 ATOM 2048 C C . GLY A 1 274 ? 41.692 110.012 -17.205 1.00 69.71 ? 264 GLY A C 1 ATOM 2049 O O . GLY A 1 274 ? 42.395 110.047 -18.224 1.00 71.92 ? 264 GLY A O 1 ATOM 2050 N N . LYS A 1 275 ? 42.042 109.329 -16.085 1.00 63.75 ? 265 LYS A N 1 ATOM 2051 C CA . LYS A 1 275 ? 43.262 108.524 -16.007 1.00 62.43 ? 265 LYS A CA 1 ATOM 2052 C C . LYS A 1 275 ? 43.068 107.252 -15.201 1.00 64.80 ? 265 LYS A C 1 ATOM 2053 O O . LYS A 1 275 ? 42.224 107.214 -14.303 1.00 65.64 ? 265 LYS A O 1 ATOM 2054 C CB . LYS A 1 275 ? 44.447 109.343 -15.457 1.00 64.74 ? 265 LYS A CB 1 ATOM 2055 C CG . LYS A 1 275 ? 44.955 110.490 -16.355 1.00 79.00 ? 265 LYS A CG 1 ATOM 2056 C CD . LYS A 1 275 ? 45.767 110.000 -17.571 1.00 88.21 ? 265 LYS A CD 1 ATOM 2057 C CE . LYS A 1 275 ? 45.932 111.036 -18.663 1.00 82.53 ? 265 LYS A CE 1 ATOM 2058 N NZ . LYS A 1 275 ? 46.976 110.634 -19.647 1.00 73.52 ? 265 LYS A NZ 1 ATOM 2059 N N . GLU A 1 276 ? 43.825 106.203 -15.546 1.00 59.49 ? 266 GLU A N 1 ATOM 2060 C CA . GLU A 1 276 ? 43.849 104.922 -14.837 1.00 59.46 ? 266 GLU A CA 1 ATOM 2061 C C . GLU A 1 276 ? 45.103 104.901 -13.942 1.00 60.95 ? 266 GLU A C 1 ATOM 2062 O O . GLU A 1 276 ? 46.226 105.046 -14.443 1.00 61.56 ? 266 GLU A O 1 ATOM 2063 C CB . GLU A 1 276 ? 43.875 103.734 -15.829 1.00 61.20 ? 266 GLU A CB 1 ATOM 2064 C CG . GLU A 1 276 ? 42.524 103.370 -16.426 1.00 74.93 ? 266 GLU A CG 1 ATOM 2065 C CD . GLU A 1 276 ? 41.442 102.785 -15.528 1.00 98.56 ? 266 GLU A CD 1 ATOM 2066 O OE1 . GLU A 1 276 ? 41.759 102.308 -14.414 1.00 89.66 ? 266 GLU A OE1 1 ATOM 2067 O OE2 . GLU A 1 276 ? 40.267 102.785 -15.962 1.00 96.20 ? 266 GLU A OE2 1 ATOM 2068 N N . TYR A 1 277 ? 44.899 104.769 -12.625 1.00 53.54 ? 267 TYR A N 1 ATOM 2069 C CA . TYR A 1 277 ? 45.973 104.740 -11.632 1.00 50.93 ? 267 TYR A CA 1 ATOM 2070 C C . TYR A 1 277 ? 46.193 103.289 -11.201 1.00 50.84 ? 267 TYR A C 1 ATOM 2071 O O . TYR A 1 277 ? 45.380 102.709 -10.481 1.00 47.52 ? 267 TYR A O 1 ATOM 2072 C CB . TYR A 1 277 ? 45.647 105.695 -10.475 1.00 50.87 ? 267 TYR A CB 1 ATOM 2073 C CG . TYR A 1 277 ? 45.606 107.149 -10.913 1.00 50.11 ? 267 TYR A CG 1 ATOM 2074 C CD1 . TYR A 1 277 ? 46.759 107.933 -10.910 1.00 49.93 ? 267 TYR A CD1 1 ATOM 2075 C CD2 . TYR A 1 277 ? 44.440 107.708 -11.437 1.00 50.65 ? 267 TYR A CD2 1 ATOM 2076 C CE1 . TYR A 1 277 ? 46.738 109.253 -11.365 1.00 47.08 ? 267 TYR A CE1 1 ATOM 2077 C CE2 . TYR A 1 277 ? 44.403 109.035 -11.873 1.00 50.77 ? 267 TYR A CE2 1 ATOM 2078 C CZ . TYR A 1 277 ? 45.557 109.801 -11.845 1.00 52.46 ? 267 TYR A CZ 1 ATOM 2079 O OH . TYR A 1 277 ? 45.516 111.105 -12.296 1.00 54.88 ? 267 TYR A OH 1 ATOM 2080 N N . THR A 1 278 ? 47.261 102.690 -11.745 1.00 47.87 ? 268 THR A N 1 ATOM 2081 C CA . THR A 1 278 ? 47.597 101.271 -11.589 1.00 48.29 ? 268 THR A CA 1 ATOM 2082 C C . THR A 1 278 ? 48.701 101.022 -10.582 1.00 52.00 ? 268 THR A C 1 ATOM 2083 O O . THR A 1 278 ? 49.741 101.683 -10.613 1.00 52.87 ? 268 THR A O 1 ATOM 2084 C CB . THR A 1 278 ? 47.939 100.654 -12.999 1.00 55.57 ? 268 THR A CB 1 ATOM 2085 O OG1 . THR A 1 278 ? 46.874 100.935 -13.906 1.00 61.92 ? 268 THR A OG1 1 ATOM 2086 C CG2 . THR A 1 278 ? 48.238 99.125 -12.978 1.00 42.99 ? 268 THR A CG2 1 ATOM 2087 N N . LEU A 1 279 ? 48.469 100.035 -9.713 1.00 47.76 ? 269 LEU A N 1 ATOM 2088 C CA . LEU A 1 279 ? 49.399 99.546 -8.697 1.00 47.10 ? 269 LEU A CA 1 ATOM 2089 C C . LEU A 1 279 ? 49.673 98.087 -9.067 1.00 50.28 ? 269 LEU A C 1 ATOM 2090 O O . LEU A 1 279 ? 48.735 97.340 -9.357 1.00 49.13 ? 269 LEU A O 1 ATOM 2091 C CB . LEU A 1 279 ? 48.753 99.540 -7.277 1.00 46.93 ? 269 LEU A CB 1 ATOM 2092 C CG . LEU A 1 279 ? 48.298 100.829 -6.527 1.00 51.42 ? 269 LEU A CG 1 ATOM 2093 C CD1 . LEU A 1 279 ? 48.928 100.901 -5.183 1.00 52.64 ? 269 LEU A CD1 1 ATOM 2094 C CD2 . LEU A 1 279 ? 48.546 102.138 -7.280 1.00 53.29 ? 269 LEU A CD2 1 ATOM 2095 N N . THR A 1 280 ? 50.945 97.675 -9.044 1.00 46.97 ? 270 THR A N 1 ATOM 2096 C CA . THR A 1 280 ? 51.318 96.272 -9.277 1.00 46.29 ? 270 THR A CA 1 ATOM 2097 C C . THR A 1 280 ? 51.393 95.588 -7.907 1.00 48.26 ? 270 THR A C 1 ATOM 2098 O O . THR A 1 280 ? 51.298 96.274 -6.890 1.00 46.63 ? 270 THR A O 1 ATOM 2099 C CB . THR A 1 280 ? 52.616 96.157 -10.072 1.00 50.87 ? 270 THR A CB 1 ATOM 2100 O OG1 . THR A 1 280 ? 53.691 96.728 -9.329 1.00 53.12 ? 270 THR A OG1 1 ATOM 2101 C CG2 . THR A 1 280 ? 52.515 96.798 -11.446 1.00 47.85 ? 270 THR A CG2 1 ATOM 2102 N N . SER A 1 281 ? 51.547 94.259 -7.868 1.00 45.05 ? 271 SER A N 1 ATOM 2103 C CA . SER A 1 281 ? 51.648 93.528 -6.595 1.00 46.26 ? 271 SER A CA 1 ATOM 2104 C C . SER A 1 281 ? 52.812 94.030 -5.696 1.00 51.76 ? 271 SER A C 1 ATOM 2105 O O . SER A 1 281 ? 52.705 94.019 -4.469 1.00 52.17 ? 271 SER A O 1 ATOM 2106 C CB . SER A 1 281 ? 51.712 92.023 -6.811 1.00 49.46 ? 271 SER A CB 1 ATOM 2107 O OG . SER A 1 281 ? 52.689 91.684 -7.778 1.00 60.67 ? 271 SER A OG 1 ATOM 2108 N N . ALA A 1 282 ? 53.862 94.575 -6.316 1.00 47.20 ? 272 ALA A N 1 ATOM 2109 C CA . ALA A 1 282 ? 55.005 95.161 -5.628 1.00 45.73 ? 272 ALA A CA 1 ATOM 2110 C C . ALA A 1 282 ? 54.584 96.435 -4.871 1.00 48.67 ? 272 ALA A C 1 ATOM 2111 O O . ALA A 1 282 ? 55.271 96.851 -3.947 1.00 46.82 ? 272 ALA A O 1 ATOM 2112 C CB . ALA A 1 282 ? 56.083 95.499 -6.645 1.00 46.36 ? 272 ALA A CB 1 ATOM 2113 N N . ASP A 1 283 ? 53.473 97.059 -5.286 1.00 45.26 ? 273 ASP A N 1 ATOM 2114 C CA . ASP A 1 283 ? 52.961 98.295 -4.709 1.00 43.82 ? 273 ASP A CA 1 ATOM 2115 C C . ASP A 1 283 ? 51.964 98.032 -3.603 1.00 48.31 ? 273 ASP A C 1 ATOM 2116 O O . ASP A 1 283 ? 51.670 98.959 -2.870 1.00 49.15 ? 273 ASP A O 1 ATOM 2117 C CB . ASP A 1 283 ? 52.318 99.191 -5.804 1.00 44.03 ? 273 ASP A CB 1 ATOM 2118 C CG . ASP A 1 283 ? 53.266 99.642 -6.891 1.00 51.77 ? 273 ASP A CG 1 ATOM 2119 O OD1 . ASP A 1 283 ? 54.368 100.131 -6.552 1.00 52.96 ? 273 ASP A OD1 1 ATOM 2120 O OD2 . ASP A 1 283 ? 52.882 99.571 -8.081 1.00 60.15 ? 273 ASP A OD2 1 ATOM 2121 N N . TYR A 1 284 ? 51.410 96.813 -3.489 1.00 43.97 ? 274 TYR A N 1 ATOM 2122 C CA . TYR A 1 284 ? 50.395 96.572 -2.461 1.00 43.14 ? 274 TYR A CA 1 ATOM 2123 C C . TYR A 1 284 ? 50.657 95.321 -1.599 1.00 47.67 ? 274 TYR A C 1 ATOM 2124 O O . TYR A 1 284 ? 49.878 95.076 -0.694 1.00 47.09 ? 274 TYR A O 1 ATOM 2125 C CB . TYR A 1 284 ? 48.970 96.575 -3.054 1.00 44.13 ? 274 TYR A CB 1 ATOM 2126 C CG . TYR A 1 284 ? 48.618 95.431 -3.987 1.00 46.54 ? 274 TYR A CG 1 ATOM 2127 C CD1 . TYR A 1 284 ? 48.181 94.209 -3.487 1.00 48.64 ? 274 TYR A CD1 1 ATOM 2128 C CD2 . TYR A 1 284 ? 48.586 95.616 -5.369 1.00 47.59 ? 274 TYR A CD2 1 ATOM 2129 C CE1 . TYR A 1 284 ? 47.830 93.162 -4.332 1.00 49.67 ? 274 TYR A CE1 1 ATOM 2130 C CE2 . TYR A 1 284 ? 48.207 94.585 -6.225 1.00 48.73 ? 274 TYR A CE2 1 ATOM 2131 C CZ . TYR A 1 284 ? 47.822 93.360 -5.696 1.00 55.30 ? 274 TYR A CZ 1 ATOM 2132 O OH . TYR A 1 284 ? 47.472 92.305 -6.497 1.00 51.25 ? 274 TYR A OH 1 ATOM 2133 N N . VAL A 1 285 ? 51.751 94.566 -1.833 1.00 43.70 ? 275 VAL A N 1 ATOM 2134 C CA . VAL A 1 285 ? 52.059 93.396 -1.001 1.00 43.44 ? 275 VAL A CA 1 ATOM 2135 C C . VAL A 1 285 ? 53.284 93.725 -0.159 1.00 48.84 ? 275 VAL A C 1 ATOM 2136 O O . VAL A 1 285 ? 54.260 94.240 -0.713 1.00 48.54 ? 275 VAL A O 1 ATOM 2137 C CB . VAL A 1 285 ? 52.295 92.063 -1.807 1.00 46.91 ? 275 VAL A CB 1 ATOM 2138 C CG1 . VAL A 1 285 ? 52.582 90.877 -0.869 1.00 46.27 ? 275 VAL A CG1 1 ATOM 2139 C CG2 . VAL A 1 285 ? 51.122 91.735 -2.722 1.00 46.84 ? 275 VAL A CG2 1 ATOM 2140 N N . PHE A 1 286 ? 53.258 93.379 1.163 1.00 45.00 ? 276 PHE A N 1 ATOM 2141 C CA . PHE A 1 286 ? 54.418 93.528 2.039 1.00 43.15 ? 276 PHE A CA 1 ATOM 2142 C C . PHE A 1 286 ? 55.201 92.230 1.873 1.00 49.70 ? 276 PHE A C 1 ATOM 2143 O O . PHE A 1 286 ? 55.022 91.260 2.625 1.00 49.47 ? 276 PHE A O 1 ATOM 2144 C CB . PHE A 1 286 ? 54.021 93.760 3.511 1.00 44.19 ? 276 PHE A CB 1 ATOM 2145 C CG . PHE A 1 286 ? 53.373 95.099 3.820 1.00 45.17 ? 276 PHE A CG 1 ATOM 2146 C CD1 . PHE A 1 286 ? 54.138 96.263 3.895 1.00 46.89 ? 276 PHE A CD1 1 ATOM 2147 C CD2 . PHE A 1 286 ? 52.004 95.192 4.080 1.00 45.22 ? 276 PHE A CD2 1 ATOM 2148 C CE1 . PHE A 1 286 ? 53.534 97.491 4.161 1.00 46.46 ? 276 PHE A CE1 1 ATOM 2149 C CE2 . PHE A 1 286 ? 51.405 96.427 4.323 1.00 47.21 ? 276 PHE A CE2 1 ATOM 2150 C CZ . PHE A 1 286 ? 52.171 97.563 4.374 1.00 44.80 ? 276 PHE A CZ 1 ATOM 2151 N N . GLN A 1 287 ? 56.006 92.185 0.817 1.00 48.14 ? 277 GLN A N 1 ATOM 2152 C CA . GLN A 1 287 ? 56.832 91.038 0.439 1.00 47.95 ? 277 GLN A CA 1 ATOM 2153 C C . GLN A 1 287 ? 57.992 90.814 1.425 1.00 57.34 ? 277 GLN A C 1 ATOM 2154 O O . GLN A 1 287 ? 59.138 91.076 1.077 1.00 58.45 ? 277 GLN A O 1 ATOM 2155 C CB . GLN A 1 287 ? 57.339 91.235 -1.003 1.00 47.72 ? 277 GLN A CB 1 ATOM 2156 C CG . GLN A 1 287 ? 57.630 89.940 -1.733 1.00 50.84 ? 277 GLN A CG 1 ATOM 2157 C CD . GLN A 1 287 ? 56.387 89.158 -2.061 1.00 68.06 ? 277 GLN A CD 1 ATOM 2158 O OE1 . GLN A 1 287 ? 55.440 89.676 -2.677 1.00 61.31 ? 277 GLN A OE1 1 ATOM 2159 N NE2 . GLN A 1 287 ? 56.387 87.878 -1.684 1.00 60.94 ? 277 GLN A NE2 1 ATOM 2160 N N . GLU A 1 288 ? 57.694 90.322 2.648 1.00 57.26 ? 278 GLU A N 1 ATOM 2161 C CA . GLU A 1 288 ? 58.669 90.060 3.727 1.00 58.08 ? 278 GLU A CA 1 ATOM 2162 C C . GLU A 1 288 ? 59.591 88.902 3.397 1.00 63.84 ? 278 GLU A C 1 ATOM 2163 O O . GLU A 1 288 ? 60.714 88.854 3.908 1.00 66.03 ? 278 GLU A O 1 ATOM 2164 C CB . GLU A 1 288 ? 57.958 89.793 5.083 1.00 59.60 ? 278 GLU A CB 1 ATOM 2165 C CG . GLU A 1 288 ? 57.302 91.002 5.735 1.00 71.30 ? 278 GLU A CG 1 ATOM 2166 C CD . GLU A 1 288 ? 58.233 92.166 6.018 1.00 98.53 ? 278 GLU A CD 1 ATOM 2167 O OE1 . GLU A 1 288 ? 59.096 92.031 6.915 1.00 103.44 ? 278 GLU A OE1 1 ATOM 2168 O OE2 . GLU A 1 288 ? 58.112 93.206 5.330 1.00 91.67 ? 278 GLU A OE2 1 ATOM 2169 N N . SER A 1 289 ? 59.090 87.943 2.595 1.00 59.77 ? 279 SER A N 1 ATOM 2170 C CA . SER A 1 289 ? 59.788 86.734 2.113 1.00 58.94 ? 279 SER A CA 1 ATOM 2171 C C . SER A 1 289 ? 59.102 86.241 0.842 1.00 61.35 ? 279 SER A C 1 ATOM 2172 O O . SER A 1 289 ? 58.145 86.863 0.377 1.00 60.91 ? 279 SER A O 1 ATOM 2173 C CB . SER A 1 289 ? 59.811 85.634 3.181 1.00 62.61 ? 279 SER A CB 1 ATOM 2174 O OG . SER A 1 289 ? 58.576 84.954 3.343 1.00 71.43 ? 279 SER A OG 1 ATOM 2175 N N . TYR A 1 290 ? 59.618 85.160 0.259 1.00 57.77 ? 280 TYR A N 1 ATOM 2176 C CA . TYR A 1 290 ? 59.084 84.522 -0.951 1.00 57.41 ? 280 TYR A CA 1 ATOM 2177 C C . TYR A 1 290 ? 58.721 83.060 -0.622 1.00 60.71 ? 280 TYR A C 1 ATOM 2178 O O . TYR A 1 290 ? 58.540 82.236 -1.522 1.00 60.04 ? 280 TYR A O 1 ATOM 2179 C CB . TYR A 1 290 ? 60.128 84.549 -2.092 1.00 57.52 ? 280 TYR A CB 1 ATOM 2180 C CG . TYR A 1 290 ? 60.520 85.915 -2.607 1.00 57.35 ? 280 TYR A CG 1 ATOM 2181 C CD1 . TYR A 1 290 ? 59.642 86.666 -3.377 1.00 58.30 ? 280 TYR A CD1 1 ATOM 2182 C CD2 . TYR A 1 290 ? 61.815 86.402 -2.432 1.00 58.68 ? 280 TYR A CD2 1 ATOM 2183 C CE1 . TYR A 1 290 ? 60.011 87.910 -3.887 1.00 59.48 ? 280 TYR A CE1 1 ATOM 2184 C CE2 . TYR A 1 290 ? 62.210 87.625 -2.972 1.00 59.47 ? 280 TYR A CE2 1 ATOM 2185 C CZ . TYR A 1 290 ? 61.305 88.376 -3.702 1.00 70.23 ? 280 TYR A CZ 1 ATOM 2186 O OH . TYR A 1 290 ? 61.688 89.594 -4.218 1.00 77.56 ? 280 TYR A OH 1 ATOM 2187 N N . SER A 1 291 ? 58.606 82.760 0.676 1.00 57.50 ? 281 SER A N 1 ATOM 2188 C CA . SER A 1 291 ? 58.341 81.432 1.198 1.00 57.65 ? 281 SER A CA 1 ATOM 2189 C C . SER A 1 291 ? 56.916 80.963 1.034 1.00 63.60 ? 281 SER A C 1 ATOM 2190 O O . SER A 1 291 ? 55.979 81.717 1.297 1.00 64.00 ? 281 SER A O 1 ATOM 2191 C CB . SER A 1 291 ? 58.725 81.364 2.669 1.00 61.83 ? 281 SER A CB 1 ATOM 2192 O OG . SER A 1 291 ? 58.480 80.074 3.218 1.00 71.64 ? 281 SER A OG 1 ATOM 2193 N N . SER A 1 292 A 56.762 79.682 0.661 1.00 60.70 ? 281 SER A N 1 ATOM 2194 C CA . SER A 1 292 A 55.478 78.978 0.551 1.00 60.40 ? 281 SER A CA 1 ATOM 2195 C C . SER A 1 292 A 54.968 78.607 1.969 1.00 62.03 ? 281 SER A C 1 ATOM 2196 O O . SER A 1 292 A 53.796 78.278 2.147 1.00 59.62 ? 281 SER A O 1 ATOM 2197 C CB . SER A 1 292 A 55.639 77.722 -0.308 1.00 65.90 ? 281 SER A CB 1 ATOM 2198 O OG . SER A 1 292 A 56.909 77.103 -0.145 1.00 77.92 ? 281 SER A OG 1 ATOM 2199 N N . LYS A 1 293 B 55.869 78.706 2.972 1.00 59.14 ? 281 LYS A N 1 ATOM 2200 C CA . LYS A 1 293 B 55.656 78.401 4.384 1.00 58.98 ? 281 LYS A CA 1 ATOM 2201 C C . LYS A 1 293 B 55.314 79.654 5.252 1.00 63.86 ? 281 LYS A C 1 ATOM 2202 O O . LYS A 1 293 B 55.190 79.547 6.484 1.00 63.86 ? 281 LYS A O 1 ATOM 2203 C CB . LYS A 1 293 B 56.903 77.687 4.929 1.00 61.14 ? 281 LYS A CB 1 ATOM 2204 C CG . LYS A 1 293 B 57.266 76.415 4.161 1.00 77.23 ? 281 LYS A CG 1 ATOM 2205 C CD . LYS A 1 293 B 58.688 75.975 4.465 1.00 81.06 ? 281 LYS A CD 1 ATOM 2206 C CE . LYS A 1 293 B 58.967 74.612 3.918 1.00 83.46 ? 281 LYS A CE 1 ATOM 2207 N NZ . LYS A 1 293 B 58.489 73.537 4.826 1.00 87.87 ? 281 LYS A NZ 1 ATOM 2208 N N . LYS A 1 294 C 55.176 80.834 4.619 1.00 59.13 ? 281 LYS A N 1 ATOM 2209 C CA . LYS A 1 294 C 54.888 82.074 5.339 1.00 57.78 ? 281 LYS A CA 1 ATOM 2210 C C . LYS A 1 294 C 53.772 82.890 4.724 1.00 59.03 ? 281 LYS A C 1 ATOM 2211 O O . LYS A 1 294 C 53.510 82.786 3.522 1.00 58.47 ? 281 LYS A O 1 ATOM 2212 C CB . LYS A 1 294 C 56.159 82.910 5.496 1.00 60.85 ? 281 LYS A CB 1 ATOM 2213 C CG . LYS A 1 294 C 56.997 82.502 6.696 1.00 72.05 ? 281 LYS A CG 1 ATOM 2214 C CD . LYS A 1 294 C 58.385 83.095 6.622 1.00 79.25 ? 281 LYS A CD 1 ATOM 2215 C CE . LYS A 1 294 C 59.315 82.412 7.582 1.00 99.87 ? 281 LYS A CE 1 ATOM 2216 N NZ . LYS A 1 294 C 60.733 82.709 7.252 1.00 114.69 ? 281 LYS A NZ 1 ATOM 2217 N N . LEU A 1 295 D 53.101 83.700 5.563 1.00 55.06 ? 281 LEU A N 1 ATOM 2218 C CA . LEU A 1 295 D 51.998 84.578 5.147 1.00 54.59 ? 281 LEU A CA 1 ATOM 2219 C C . LEU A 1 295 D 52.474 86.018 4.977 1.00 57.70 ? 281 LEU A C 1 ATOM 2220 O O . LEU A 1 295 D 53.291 86.511 5.771 1.00 58.08 ? 281 LEU A O 1 ATOM 2221 C CB . LEU A 1 295 D 50.832 84.530 6.140 1.00 54.68 ? 281 LEU A CB 1 ATOM 2222 C CG . LEU A 1 295 D 50.113 83.188 6.298 1.00 59.59 ? 281 LEU A CG 1 ATOM 2223 C CD1 . LEU A 1 295 D 49.056 83.289 7.380 1.00 59.93 ? 281 LEU A CD1 1 ATOM 2224 C CD2 . LEU A 1 295 D 49.481 82.718 4.974 1.00 60.51 ? 281 LEU A CD2 1 ATOM 2225 N N . CYS A 1 296 ? 52.000 86.670 3.908 1.00 51.79 ? 282 CYS A N 1 ATOM 2226 C CA . CYS A 1 296 ? 52.363 88.034 3.556 1.00 50.91 ? 282 CYS A CA 1 ATOM 2227 C C . CYS A 1 296 ? 51.119 88.886 3.553 1.00 52.84 ? 282 CYS A C 1 ATOM 2228 O O . CYS A 1 296 ? 50.116 88.488 2.974 1.00 52.12 ? 282 CYS A O 1 ATOM 2229 C CB . CYS A 1 296 ? 53.086 88.079 2.210 1.00 51.33 ? 282 CYS A CB 1 ATOM 2230 S SG . CYS A 1 296 ? 54.870 87.761 2.310 1.00 55.20 ? 282 CYS A SG 1 ATOM 2231 N N . THR A 1 297 ? 51.164 90.041 4.241 1.00 48.45 ? 283 THR A N 1 ATOM 2232 C CA . THR A 1 297 ? 50.023 90.951 4.348 1.00 48.08 ? 283 THR A CA 1 ATOM 2233 C C . THR A 1 297 ? 49.941 91.868 3.129 1.00 51.15 ? 283 THR A C 1 ATOM 2234 O O . THR A 1 297 ? 50.958 92.132 2.479 1.00 50.45 ? 283 THR A O 1 ATOM 2235 C CB . THR A 1 297 ? 50.124 91.754 5.677 1.00 56.32 ? 283 THR A CB 1 ATOM 2236 O OG1 . THR A 1 297 ? 50.101 90.886 6.820 1.00 60.05 ? 283 THR A OG1 1 ATOM 2237 C CG2 . THR A 1 297 ? 49.076 92.867 5.819 1.00 51.56 ? 283 THR A CG2 1 ATOM 2238 N N . LEU A 1 298 ? 48.734 92.398 2.862 1.00 47.27 ? 284 LEU A N 1 ATOM 2239 C CA . LEU A 1 298 ? 48.501 93.355 1.783 1.00 47.25 ? 284 LEU A CA 1 ATOM 2240 C C . LEU A 1 298 ? 48.257 94.733 2.344 1.00 52.32 ? 284 LEU A C 1 ATOM 2241 O O . LEU A 1 298 ? 47.749 94.854 3.450 1.00 54.24 ? 284 LEU A O 1 ATOM 2242 C CB . LEU A 1 298 ? 47.340 92.935 0.850 1.00 47.20 ? 284 LEU A CB 1 ATOM 2243 C CG . LEU A 1 298 ? 47.253 91.455 0.390 1.00 51.84 ? 284 LEU A CG 1 ATOM 2244 C CD1 . LEU A 1 298 ? 46.292 91.324 -0.759 1.00 51.84 ? 284 LEU A CD1 1 ATOM 2245 C CD2 . LEU A 1 298 ? 48.604 90.904 -0.064 1.00 52.70 ? 284 LEU A CD2 1 ATOM 2246 N N . ALA A 1 299 ? 48.573 95.774 1.579 1.00 47.66 ? 285 ALA A N 1 ATOM 2247 C CA . ALA A 1 299 ? 48.363 97.151 2.026 1.00 46.98 ? 285 ALA A CA 1 ATOM 2248 C C . ALA A 1 299 ? 46.962 97.698 1.621 1.00 50.02 ? 285 ALA A C 1 ATOM 2249 O O . ALA A 1 299 ? 46.769 98.887 1.327 1.00 48.05 ? 285 ALA A O 1 ATOM 2250 C CB . ALA A 1 299 ? 49.499 98.041 1.554 1.00 47.26 ? 285 ALA A CB 1 ATOM 2251 N N . ILE A 1 300 ? 45.979 96.791 1.655 1.00 47.05 ? 286 ILE A N 1 ATOM 2252 C CA . ILE A 1 300 ? 44.563 97.008 1.342 1.00 46.35 ? 286 ILE A CA 1 ATOM 2253 C C . ILE A 1 300 ? 43.782 96.267 2.419 1.00 52.95 ? 286 ILE A C 1 ATOM 2254 O O . ILE A 1 300 ? 44.050 95.090 2.664 1.00 52.55 ? 286 ILE A O 1 ATOM 2255 C CB . ILE A 1 300 ? 44.170 96.489 -0.070 1.00 48.13 ? 286 ILE A CB 1 ATOM 2256 C CG1 . ILE A 1 300 ? 45.148 96.967 -1.153 1.00 47.75 ? 286 ILE A CG1 1 ATOM 2257 C CG2 . ILE A 1 300 ? 42.726 96.890 -0.404 1.00 48.97 ? 286 ILE A CG2 1 ATOM 2258 C CD1 . ILE A 1 300 ? 45.246 96.078 -2.359 1.00 53.71 ? 286 ILE A CD1 1 ATOM 2259 N N . HIS A 1 301 ? 42.825 96.948 3.056 1.00 53.12 ? 287 HIS A N 1 ATOM 2260 C CA . HIS A 1 301 ? 41.966 96.389 4.118 1.00 54.61 ? 287 HIS A CA 1 ATOM 2261 C C . HIS A 1 301 ? 40.518 96.948 4.048 1.00 57.67 ? 287 HIS A C 1 ATOM 2262 O O . HIS A 1 301 ? 40.261 97.943 3.359 1.00 57.15 ? 287 HIS A O 1 ATOM 2263 C CB . HIS A 1 301 ? 42.605 96.635 5.509 1.00 56.33 ? 287 HIS A CB 1 ATOM 2264 C CG . HIS A 1 301 ? 42.429 98.026 6.036 1.00 61.16 ? 287 HIS A CG 1 ATOM 2265 N ND1 . HIS A 1 301 ? 41.936 98.252 7.309 1.00 64.04 ? 287 HIS A ND1 1 ATOM 2266 C CD2 . HIS A 1 301 ? 42.640 99.223 5.435 1.00 63.87 ? 287 HIS A CD2 1 ATOM 2267 C CE1 . HIS A 1 301 ? 41.907 99.568 7.459 1.00 63.52 ? 287 HIS A CE1 1 ATOM 2268 N NE2 . HIS A 1 301 ? 42.307 100.197 6.355 1.00 63.85 ? 287 HIS A NE2 1 ATOM 2269 N N . ALA A 1 302 ? 39.587 96.328 4.770 1.00 54.16 ? 288 ALA A N 1 ATOM 2270 C CA . ALA A 1 302 ? 38.200 96.809 4.772 1.00 53.69 ? 288 ALA A CA 1 ATOM 2271 C C . ALA A 1 302 ? 38.027 97.870 5.811 1.00 56.76 ? 288 ALA A C 1 ATOM 2272 O O . ALA A 1 302 ? 38.608 97.784 6.901 1.00 53.90 ? 288 ALA A O 1 ATOM 2273 C CB . ALA A 1 302 ? 37.224 95.670 5.027 1.00 54.17 ? 288 ALA A CB 1 ATOM 2274 N N . MET A 1 303 ? 37.250 98.893 5.453 1.00 56.04 ? 289 MET A N 1 ATOM 2275 C CA . MET A 1 303 ? 36.879 99.981 6.339 1.00 57.32 ? 289 MET A CA 1 ATOM 2276 C C . MET A 1 303 ? 35.596 100.638 5.901 1.00 63.43 ? 289 MET A C 1 ATOM 2277 O O . MET A 1 303 ? 35.521 101.218 4.817 1.00 62.78 ? 289 MET A O 1 ATOM 2278 C CB . MET A 1 303 ? 37.992 100.994 6.574 1.00 59.90 ? 289 MET A CB 1 ATOM 2279 C CG . MET A 1 303 ? 37.943 101.505 7.965 1.00 64.53 ? 289 MET A CG 1 ATOM 2280 S SD . MET A 1 303 ? 38.965 102.929 8.191 1.00 69.75 ? 289 MET A SD 1 ATOM 2281 C CE . MET A 1 303 ? 40.497 102.154 8.632 1.00 66.48 ? 289 MET A CE 1 ATOM 2282 N N . ASP A 1 304 ? 34.565 100.483 6.736 1.00 62.51 ? 290 ASP A N 1 ATOM 2283 C CA . ASP A 1 304 ? 33.250 101.052 6.480 1.00 63.69 ? 290 ASP A CA 1 ATOM 2284 C C . ASP A 1 304 ? 33.213 102.412 7.142 1.00 69.92 ? 290 ASP A C 1 ATOM 2285 O O . ASP A 1 304 ? 33.058 102.522 8.360 1.00 69.08 ? 290 ASP A O 1 ATOM 2286 C CB . ASP A 1 304 ? 32.109 100.125 6.960 1.00 65.22 ? 290 ASP A CB 1 ATOM 2287 C CG . ASP A 1 304 ? 32.184 98.697 6.423 1.00 74.19 ? 290 ASP A CG 1 ATOM 2288 O OD1 . ASP A 1 304 ? 32.076 98.519 5.192 1.00 73.48 ? 290 ASP A OD1 1 ATOM 2289 O OD2 . ASP A 1 304 ? 32.326 97.759 7.242 1.00 79.01 ? 290 ASP A OD2 1 ATOM 2290 N N . ILE A 1 305 ? 33.482 103.444 6.337 1.00 68.20 ? 291 ILE A N 1 ATOM 2291 C CA . ILE A 1 305 ? 33.467 104.835 6.775 1.00 68.56 ? 291 ILE A CA 1 ATOM 2292 C C . ILE A 1 305 ? 31.994 105.210 6.807 1.00 74.08 ? 291 ILE A C 1 ATOM 2293 O O . ILE A 1 305 ? 31.278 104.913 5.848 1.00 73.54 ? 291 ILE A O 1 ATOM 2294 C CB . ILE A 1 305 ? 34.338 105.749 5.848 1.00 71.26 ? 291 ILE A CB 1 ATOM 2295 C CG1 . ILE A 1 305 ? 35.846 105.437 6.031 1.00 71.09 ? 291 ILE A CG1 1 ATOM 2296 C CG2 . ILE A 1 305 ? 34.058 107.245 6.064 1.00 70.52 ? 291 ILE A CG2 1 ATOM 2297 C CD1 . ILE A 1 305 ? 36.620 105.193 4.760 1.00 70.89 ? 291 ILE A CD1 1 ATOM 2298 N N . PRO A 1 306 ? 31.507 105.768 7.933 1.00 72.52 ? 292 PRO A N 1 ATOM 2299 C CA . PRO A 1 306 ? 30.072 106.102 8.030 1.00 72.43 ? 292 PRO A CA 1 ATOM 2300 C C . PRO A 1 306 ? 29.636 107.305 7.192 1.00 74.87 ? 292 PRO A C 1 ATOM 2301 O O . PRO A 1 306 ? 30.475 108.159 6.881 1.00 73.58 ? 292 PRO A O 1 ATOM 2302 C CB . PRO A 1 306 ? 29.896 106.406 9.519 1.00 74.36 ? 292 PRO A CB 1 ATOM 2303 C CG . PRO A 1 306 ? 31.229 106.936 9.944 1.00 78.93 ? 292 PRO A CG 1 ATOM 2304 C CD . PRO A 1 306 ? 32.236 106.139 9.166 1.00 74.32 ? 292 PRO A CD 1 ATOM 2305 N N . PRO A 1 307 ? 28.315 107.442 6.893 1.00 72.24 ? 293 PRO A N 1 ATOM 2306 C CA . PRO A 1 307 ? 27.838 108.660 6.215 1.00 71.65 ? 293 PRO A CA 1 ATOM 2307 C C . PRO A 1 307 ? 27.932 109.868 7.172 1.00 73.09 ? 293 PRO A C 1 ATOM 2308 O O . PRO A 1 307 ? 28.064 109.669 8.394 1.00 71.92 ? 293 PRO A O 1 ATOM 2309 C CB . PRO A 1 307 ? 26.383 108.325 5.847 1.00 73.47 ? 293 PRO A CB 1 ATOM 2310 C CG . PRO A 1 307 ? 26.226 106.855 6.103 1.00 78.23 ? 293 PRO A CG 1 ATOM 2311 C CD . PRO A 1 307 ? 27.179 106.554 7.207 1.00 73.88 ? 293 PRO A CD 1 ATOM 2312 N N . PRO A 1 308 ? 27.972 111.124 6.672 1.00 67.38 ? 294 PRO A N 1 ATOM 2313 C CA . PRO A 1 308 ? 27.821 111.580 5.279 1.00 66.76 ? 294 PRO A CA 1 ATOM 2314 C C . PRO A 1 308 ? 28.969 111.258 4.324 1.00 73.53 ? 294 PRO A C 1 ATOM 2315 O O . PRO A 1 308 ? 28.706 111.055 3.133 1.00 74.53 ? 294 PRO A O 1 ATOM 2316 C CB . PRO A 1 308 ? 27.632 113.093 5.431 1.00 68.03 ? 294 PRO A CB 1 ATOM 2317 C CG . PRO A 1 308 ? 28.306 113.440 6.707 1.00 72.25 ? 294 PRO A CG 1 ATOM 2318 C CD . PRO A 1 308 ? 28.073 112.266 7.602 1.00 68.07 ? 294 PRO A CD 1 ATOM 2319 N N . THR A 1 309 ? 30.222 111.229 4.832 1.00 70.34 ? 295 THR A N 1 ATOM 2320 C CA . THR A 1 309 ? 31.451 110.966 4.070 1.00 69.65 ? 295 THR A CA 1 ATOM 2321 C C . THR A 1 309 ? 31.389 109.602 3.362 1.00 71.42 ? 295 THR A C 1 ATOM 2322 O O . THR A 1 309 ? 31.613 109.533 2.152 1.00 71.20 ? 295 THR A O 1 ATOM 2323 C CB . THR A 1 309 ? 32.707 111.155 4.969 1.00 74.58 ? 295 THR A CB 1 ATOM 2324 O OG1 . THR A 1 309 ? 32.706 112.477 5.510 1.00 71.24 ? 295 THR A OG1 1 ATOM 2325 C CG2 . THR A 1 309 ? 34.014 110.941 4.211 1.00 72.37 ? 295 THR A CG2 1 ATOM 2326 N N . GLY A 1 310 ? 31.052 108.564 4.116 1.00 66.41 ? 296 GLY A N 1 ATOM 2327 C CA . GLY A 1 310 ? 30.942 107.208 3.610 1.00 66.45 ? 296 GLY A CA 1 ATOM 2328 C C . GLY A 1 310 ? 29.543 106.785 3.182 1.00 72.53 ? 296 GLY A C 1 ATOM 2329 O O . GLY A 1 310 ? 28.580 107.544 3.329 1.00 73.57 ? 296 GLY A O 1 ATOM 2330 N N . PRO A 1 311 ? 29.373 105.555 2.650 1.00 67.96 ? 297 PRO A N 1 ATOM 2331 C CA . PRO A 1 311 ? 30.406 104.549 2.351 1.00 66.65 ? 297 PRO A CA 1 ATOM 2332 C C . PRO A 1 311 ? 31.331 105.111 1.275 1.00 66.77 ? 297 PRO A C 1 ATOM 2333 O O . PRO A 1 311 ? 30.857 105.811 0.377 1.00 65.89 ? 297 PRO A O 1 ATOM 2334 C CB . PRO A 1 311 ? 29.586 103.342 1.846 1.00 68.69 ? 297 PRO A CB 1 ATOM 2335 C CG . PRO A 1 311 ? 28.170 103.603 2.285 1.00 73.34 ? 297 PRO A CG 1 ATOM 2336 C CD . PRO A 1 311 ? 28.044 105.091 2.214 1.00 69.20 ? 297 PRO A CD 1 ATOM 2337 N N . THR A 1 312 ? 32.654 104.873 1.413 1.00 61.11 ? 298 THR A N 1 ATOM 2338 C CA . THR A 1 312 ? 33.679 105.368 0.488 1.00 59.03 ? 298 THR A CA 1 ATOM 2339 C C . THR A 1 312 ? 34.934 104.546 0.531 1.00 63.48 ? 298 THR A C 1 ATOM 2340 O O . THR A 1 312 ? 35.231 103.902 1.542 1.00 64.57 ? 298 THR A O 1 ATOM 2341 C CB . THR A 1 312 ? 34.023 106.841 0.798 1.00 55.80 ? 298 THR A CB 1 ATOM 2342 O OG1 . THR A 1 312 ? 34.940 107.341 -0.177 1.00 53.71 ? 298 THR A OG1 1 ATOM 2343 C CG2 . THR A 1 312 ? 34.591 107.048 2.208 1.00 50.49 ? 298 THR A CG2 1 ATOM 2344 N N . TRP A 1 313 ? 35.702 104.601 -0.552 1.00 59.69 ? 299 TRP A N 1 ATOM 2345 C CA . TRP A 1 313 ? 37.029 104.003 -0.590 1.00 59.19 ? 299 TRP A CA 1 ATOM 2346 C C . TRP A 1 313 ? 37.935 105.073 0.018 1.00 57.59 ? 299 TRP A C 1 ATOM 2347 O O . TRP A 1 313 ? 37.569 106.259 0.037 1.00 56.10 ? 299 TRP A O 1 ATOM 2348 C CB . TRP A 1 313 ? 37.485 103.739 -2.038 1.00 58.93 ? 299 TRP A CB 1 ATOM 2349 C CG . TRP A 1 313 ? 36.797 102.589 -2.693 1.00 60.91 ? 299 TRP A CG 1 ATOM 2350 C CD1 . TRP A 1 313 ? 35.531 102.576 -3.197 1.00 63.99 ? 299 TRP A CD1 1 ATOM 2351 C CD2 . TRP A 1 313 ? 37.375 101.316 -3.022 1.00 61.37 ? 299 TRP A CD2 1 ATOM 2352 N NE1 . TRP A 1 313 ? 35.259 101.350 -3.764 1.00 64.09 ? 299 TRP A NE1 1 ATOM 2353 C CE2 . TRP A 1 313 ? 36.370 100.552 -3.660 1.00 65.18 ? 299 TRP A CE2 1 ATOM 2354 C CE3 . TRP A 1 313 ? 38.630 100.720 -2.782 1.00 63.27 ? 299 TRP A CE3 1 ATOM 2355 C CZ2 . TRP A 1 313 ? 36.580 99.231 -4.076 1.00 64.04 ? 299 TRP A CZ2 1 ATOM 2356 C CZ3 . TRP A 1 313 ? 38.836 99.407 -3.191 1.00 64.76 ? 299 TRP A CZ3 1 ATOM 2357 C CH2 . TRP A 1 313 ? 37.819 98.680 -3.835 1.00 65.09 ? 299 TRP A CH2 1 ATOM 2358 N N . ALA A 1 314 ? 39.105 104.660 0.507 1.00 49.82 ? 300 ALA A N 1 ATOM 2359 C CA . ALA A 1 314 ? 40.091 105.575 1.047 1.00 47.72 ? 300 ALA A CA 1 ATOM 2360 C C . ALA A 1 314 ? 41.429 105.234 0.424 1.00 49.83 ? 300 ALA A C 1 ATOM 2361 O O . ALA A 1 314 ? 41.879 104.086 0.511 1.00 48.85 ? 300 ALA A O 1 ATOM 2362 C CB . ALA A 1 314 ? 40.152 105.458 2.558 1.00 47.64 ? 300 ALA A CB 1 ATOM 2363 N N . LEU A 1 315 ? 42.034 106.217 -0.262 1.00 44.66 ? 301 LEU A N 1 ATOM 2364 C CA . LEU A 1 315 ? 43.349 106.065 -0.904 1.00 43.45 ? 301 LEU A CA 1 ATOM 2365 C C . LEU A 1 315 ? 44.410 106.617 0.045 1.00 44.09 ? 301 LEU A C 1 ATOM 2366 O O . LEU A 1 315 ? 44.582 107.832 0.142 1.00 43.28 ? 301 LEU A O 1 ATOM 2367 C CB . LEU A 1 315 ? 43.359 106.785 -2.289 1.00 43.14 ? 301 LEU A CB 1 ATOM 2368 C CG . LEU A 1 315 ? 42.319 106.293 -3.326 1.00 46.20 ? 301 LEU A CG 1 ATOM 2369 C CD1 . LEU A 1 315 ? 42.345 107.154 -4.603 1.00 46.57 ? 301 LEU A CD1 1 ATOM 2370 C CD2 . LEU A 1 315 ? 42.489 104.781 -3.642 1.00 42.22 ? 301 LEU A CD2 1 ATOM 2371 N N . GLY A 1 316 ? 45.012 105.720 0.823 1.00 41.61 ? 302 GLY A N 1 ATOM 2372 C CA . GLY A 1 316 ? 46.026 106.048 1.821 1.00 41.38 ? 302 GLY A CA 1 ATOM 2373 C C . GLY A 1 316 ? 47.454 105.989 1.314 1.00 44.68 ? 302 GLY A C 1 ATOM 2374 O O . GLY A 1 316 ? 47.704 106.174 0.113 1.00 44.27 ? 302 GLY A O 1 ATOM 2375 N N . ALA A 1 317 ? 48.411 105.727 2.236 1.00 40.39 ? 303 ALA A N 1 ATOM 2376 C CA . ALA A 1 317 ? 49.848 105.730 1.903 1.00 39.03 ? 303 ALA A CA 1 ATOM 2377 C C . ALA A 1 317 ? 50.222 104.743 0.787 1.00 42.75 ? 303 ALA A C 1 ATOM 2378 O O . ALA A 1 317 ? 51.158 105.034 0.056 1.00 42.82 ? 303 ALA A O 1 ATOM 2379 C CB . ALA A 1 317 ? 50.701 105.522 3.138 1.00 38.86 ? 303 ALA A CB 1 ATOM 2380 N N . THR A 1 318 ? 49.471 103.618 0.622 1.00 38.58 ? 304 THR A N 1 ATOM 2381 C CA . THR A 1 318 ? 49.704 102.636 -0.442 1.00 38.57 ? 304 THR A CA 1 ATOM 2382 C C . THR A 1 318 ? 49.607 103.329 -1.824 1.00 46.17 ? 304 THR A C 1 ATOM 2383 O O . THR A 1 318 ? 50.486 103.143 -2.681 1.00 46.32 ? 304 THR A O 1 ATOM 2384 C CB . THR A 1 318 ? 48.710 101.468 -0.325 1.00 37.70 ? 304 THR A CB 1 ATOM 2385 O OG1 . THR A 1 318 ? 48.665 101.026 1.016 1.00 31.81 ? 304 THR A OG1 1 ATOM 2386 C CG2 . THR A 1 318 ? 49.040 100.311 -1.255 1.00 28.48 ? 304 THR A CG2 1 ATOM 2387 N N . PHE A 1 319 ? 48.553 104.160 -2.001 1.00 42.64 ? 305 PHE A N 1 ATOM 2388 C CA . PHE A 1 319 ? 48.316 104.931 -3.213 1.00 40.60 ? 305 PHE A CA 1 ATOM 2389 C C . PHE A 1 319 ? 49.312 106.083 -3.380 1.00 44.06 ? 305 PHE A C 1 ATOM 2390 O O . PHE A 1 319 ? 49.879 106.241 -4.457 1.00 44.44 ? 305 PHE A O 1 ATOM 2391 C CB . PHE A 1 319 ? 46.836 105.412 -3.287 1.00 40.99 ? 305 PHE A CB 1 ATOM 2392 C CG . PHE A 1 319 ? 46.419 105.943 -4.646 1.00 40.57 ? 305 PHE A CG 1 ATOM 2393 C CD1 . PHE A 1 319 ? 45.989 105.077 -5.652 1.00 41.87 ? 305 PHE A CD1 1 ATOM 2394 C CD2 . PHE A 1 319 ? 46.477 107.302 -4.928 1.00 40.54 ? 305 PHE A CD2 1 ATOM 2395 C CE1 . PHE A 1 319 ? 45.656 105.559 -6.921 1.00 40.80 ? 305 PHE A CE1 1 ATOM 2396 C CE2 . PHE A 1 319 ? 46.099 107.782 -6.184 1.00 42.86 ? 305 PHE A CE2 1 ATOM 2397 C CZ . PHE A 1 319 ? 45.686 106.906 -7.163 1.00 40.10 ? 305 PHE A CZ 1 ATOM 2398 N N . ILE A 1 320 ? 49.505 106.889 -2.335 1.00 41.09 ? 306 ILE A N 1 ATOM 2399 C CA . ILE A 1 320 ? 50.372 108.084 -2.368 1.00 41.29 ? 306 ILE A CA 1 ATOM 2400 C C . ILE A 1 320 ? 51.863 107.718 -2.612 1.00 46.32 ? 306 ILE A C 1 ATOM 2401 O O . ILE A 1 320 ? 52.604 108.516 -3.207 1.00 46.63 ? 306 ILE A O 1 ATOM 2402 C CB . ILE A 1 320 ? 50.144 108.964 -1.106 1.00 43.98 ? 306 ILE A CB 1 ATOM 2403 C CG1 . ILE A 1 320 ? 48.658 109.402 -1.023 1.00 44.33 ? 306 ILE A CG1 1 ATOM 2404 C CG2 . ILE A 1 320 ? 51.089 110.182 -1.057 1.00 43.89 ? 306 ILE A CG2 1 ATOM 2405 C CD1 . ILE A 1 320 ? 48.093 109.423 0.320 1.00 48.49 ? 306 ILE A CD1 1 ATOM 2406 N N . ARG A 1 321 ? 52.289 106.510 -2.214 1.00 41.44 ? 307 ARG A N 1 ATOM 2407 C CA . ARG A 1 321 ? 53.669 106.098 -2.486 1.00 40.53 ? 307 ARG A CA 1 ATOM 2408 C C . ARG A 1 321 ? 53.909 106.069 -3.989 1.00 47.29 ? 307 ARG A C 1 ATOM 2409 O O . ARG A 1 321 ? 54.931 106.573 -4.458 1.00 49.12 ? 307 ARG A O 1 ATOM 2410 C CB . ARG A 1 321 ? 53.980 104.734 -1.877 1.00 34.98 ? 307 ARG A CB 1 ATOM 2411 C CG . ARG A 1 321 ? 54.669 104.819 -0.551 1.00 40.95 ? 307 ARG A CG 1 ATOM 2412 C CD . ARG A 1 321 ? 55.217 103.451 -0.175 1.00 44.33 ? 307 ARG A CD 1 ATOM 2413 N NE . ARG A 1 321 ? 54.156 102.445 0.048 1.00 38.86 ? 307 ARG A NE 1 ATOM 2414 C CZ . ARG A 1 321 ? 53.495 102.284 1.196 1.00 57.72 ? 307 ARG A CZ 1 ATOM 2415 N NH1 . ARG A 1 321 ? 53.746 103.077 2.231 1.00 50.65 ? 307 ARG A NH1 1 ATOM 2416 N NH2 . ARG A 1 321 ? 52.576 101.327 1.317 1.00 41.41 ? 307 ARG A NH2 1 ATOM 2417 N N . LYS A 1 322 ? 52.948 105.520 -4.741 1.00 43.46 ? 308 LYS A N 1 ATOM 2418 C CA . LYS A 1 322 ? 53.046 105.427 -6.195 1.00 42.73 ? 308 LYS A CA 1 ATOM 2419 C C . LYS A 1 322 ? 52.813 106.823 -6.852 1.00 41.17 ? 308 LYS A C 1 ATOM 2420 O O . LYS A 1 322 ? 53.537 107.204 -7.781 1.00 38.61 ? 308 LYS A O 1 ATOM 2421 C CB . LYS A 1 322 ? 52.045 104.340 -6.707 1.00 45.84 ? 308 LYS A CB 1 ATOM 2422 C CG . LYS A 1 322 ? 52.107 103.986 -8.185 1.00 52.83 ? 308 LYS A CG 1 ATOM 2423 C CD . LYS A 1 322 ? 53.235 103.078 -8.562 1.00 61.21 ? 308 LYS A CD 1 ATOM 2424 C CE . LYS A 1 322 ? 53.257 102.860 -10.059 1.00 57.24 ? 308 LYS A CE 1 ATOM 2425 N NZ . LYS A 1 322 ? 52.535 101.611 -10.448 1.00 59.95 ? 308 LYS A NZ 1 ATOM 2426 N N . PHE A 1 323 ? 51.831 107.584 -6.323 1.00 34.80 ? 309 PHE A N 1 ATOM 2427 C CA . PHE A 1 323 ? 51.434 108.865 -6.899 1.00 33.25 ? 309 PHE A CA 1 ATOM 2428 C C . PHE A 1 323 ? 51.578 110.071 -5.985 1.00 38.56 ? 309 PHE A C 1 ATOM 2429 O O . PHE A 1 323 ? 50.839 110.215 -5.014 1.00 38.57 ? 309 PHE A O 1 ATOM 2430 C CB . PHE A 1 323 ? 49.987 108.764 -7.435 1.00 33.84 ? 309 PHE A CB 1 ATOM 2431 C CG . PHE A 1 323 ? 49.810 107.605 -8.411 1.00 33.83 ? 309 PHE A CG 1 ATOM 2432 C CD1 . PHE A 1 323 ? 50.315 107.681 -9.707 1.00 36.81 ? 309 PHE A CD1 1 ATOM 2433 C CD2 . PHE A 1 323 ? 49.180 106.419 -8.012 1.00 33.45 ? 309 PHE A CD2 1 ATOM 2434 C CE1 . PHE A 1 323 ? 50.169 106.601 -10.593 1.00 37.83 ? 309 PHE A CE1 1 ATOM 2435 C CE2 . PHE A 1 323 ? 48.990 105.357 -8.906 1.00 36.67 ? 309 PHE A CE2 1 ATOM 2436 C CZ . PHE A 1 323 ? 49.486 105.446 -10.190 1.00 36.00 ? 309 PHE A CZ 1 ATOM 2437 N N . TYR A 1 324 ? 52.516 110.975 -6.333 1.00 37.24 ? 310 TYR A N 1 ATOM 2438 C CA . TYR A 1 324 ? 52.732 112.277 -5.669 1.00 37.72 ? 310 TYR A CA 1 ATOM 2439 C C . TYR A 1 324 ? 51.379 113.019 -5.721 1.00 46.15 ? 310 TYR A C 1 ATOM 2440 O O . TYR A 1 324 ? 50.731 113.046 -6.773 1.00 47.29 ? 310 TYR A O 1 ATOM 2441 C CB . TYR A 1 324 ? 53.845 113.069 -6.392 1.00 38.28 ? 310 TYR A CB 1 ATOM 2442 C CG . TYR A 1 324 ? 54.286 114.329 -5.673 1.00 39.98 ? 310 TYR A CG 1 ATOM 2443 C CD1 . TYR A 1 324 ? 53.589 115.529 -5.827 1.00 40.71 ? 310 TYR A CD1 1 ATOM 2444 C CD2 . TYR A 1 324 ? 55.422 114.336 -4.862 1.00 41.08 ? 310 TYR A CD2 1 ATOM 2445 C CE1 . TYR A 1 324 ? 53.988 116.694 -5.167 1.00 37.95 ? 310 TYR A CE1 1 ATOM 2446 C CE2 . TYR A 1 324 ? 55.825 115.499 -4.189 1.00 41.47 ? 310 TYR A CE2 1 ATOM 2447 C CZ . TYR A 1 324 ? 55.098 116.670 -4.342 1.00 45.36 ? 310 TYR A CZ 1 ATOM 2448 O OH . TYR A 1 324 ? 55.474 117.801 -3.681 1.00 49.12 ? 310 TYR A OH 1 ATOM 2449 N N . THR A 1 325 ? 50.915 113.551 -4.585 1.00 43.64 ? 311 THR A N 1 ATOM 2450 C CA . THR A 1 325 ? 49.589 114.181 -4.480 1.00 42.85 ? 311 THR A CA 1 ATOM 2451 C C . THR A 1 325 ? 49.622 115.680 -4.116 1.00 47.92 ? 311 THR A C 1 ATOM 2452 O O . THR A 1 325 ? 50.310 116.076 -3.189 1.00 49.38 ? 311 THR A O 1 ATOM 2453 C CB . THR A 1 325 ? 48.739 113.360 -3.486 1.00 44.30 ? 311 THR A CB 1 ATOM 2454 O OG1 . THR A 1 325 ? 48.812 111.982 -3.860 1.00 37.95 ? 311 THR A OG1 1 ATOM 2455 C CG2 . THR A 1 325 ? 47.284 113.790 -3.452 1.00 43.75 ? 311 THR A CG2 1 ATOM 2456 N N . GLU A 1 326 ? 48.874 116.499 -4.861 1.00 44.20 ? 312 GLU A N 1 ATOM 2457 C CA . GLU A 1 326 ? 48.726 117.935 -4.598 1.00 43.74 ? 312 GLU A CA 1 ATOM 2458 C C . GLU A 1 326 ? 47.257 118.220 -4.237 1.00 49.21 ? 312 GLU A C 1 ATOM 2459 O O . GLU A 1 326 ? 46.336 117.762 -4.930 1.00 49.72 ? 312 GLU A O 1 ATOM 2460 C CB . GLU A 1 326 ? 49.171 118.785 -5.786 1.00 44.66 ? 312 GLU A CB 1 ATOM 2461 C CG . GLU A 1 326 ? 49.117 120.278 -5.483 1.00 54.34 ? 312 GLU A CG 1 ATOM 2462 C CD . GLU A 1 326 ? 49.465 121.162 -6.663 1.00 82.71 ? 312 GLU A CD 1 ATOM 2463 O OE1 . GLU A 1 326 ? 48.622 121.293 -7.576 1.00 67.75 ? 312 GLU A OE1 1 ATOM 2464 O OE2 . GLU A 1 326 ? 50.584 121.718 -6.683 1.00 91.81 ? 312 GLU A OE2 1 ATOM 2465 N N . PHE A 1 327 ? 47.045 118.916 -3.115 1.00 44.34 ? 313 PHE A N 1 ATOM 2466 C CA . PHE A 1 327 ? 45.731 119.264 -2.599 1.00 43.35 ? 313 PHE A CA 1 ATOM 2467 C C . PHE A 1 327 ? 45.577 120.769 -2.803 1.00 51.89 ? 313 PHE A C 1 ATOM 2468 O O . PHE A 1 327 ? 46.256 121.593 -2.164 1.00 49.91 ? 313 PHE A O 1 ATOM 2469 C CB . PHE A 1 327 ? 45.642 118.916 -1.127 1.00 44.11 ? 313 PHE A CB 1 ATOM 2470 C CG . PHE A 1 327 ? 45.777 117.448 -0.836 1.00 44.41 ? 313 PHE A CG 1 ATOM 2471 C CD1 . PHE A 1 327 ? 47.021 116.888 -0.582 1.00 45.61 ? 313 PHE A CD1 1 ATOM 2472 C CD2 . PHE A 1 327 ? 44.655 116.628 -0.793 1.00 46.05 ? 313 PHE A CD2 1 ATOM 2473 C CE1 . PHE A 1 327 ? 47.147 115.527 -0.332 1.00 47.21 ? 313 PHE A CE1 1 ATOM 2474 C CE2 . PHE A 1 327 ? 44.775 115.274 -0.508 1.00 49.40 ? 313 PHE A CE2 1 ATOM 2475 C CZ . PHE A 1 327 ? 46.025 114.729 -0.280 1.00 47.59 ? 313 PHE A CZ 1 ATOM 2476 N N . ASP A 1 328 ? 44.717 121.107 -3.760 1.00 50.88 ? 314 ASP A N 1 ATOM 2477 C CA . ASP A 1 328 ? 44.469 122.457 -4.213 1.00 51.92 ? 314 ASP A CA 1 ATOM 2478 C C . ASP A 1 328 ? 43.227 123.062 -3.550 1.00 56.50 ? 314 ASP A C 1 ATOM 2479 O O . ASP A 1 328 ? 42.110 122.721 -3.927 1.00 55.45 ? 314 ASP A O 1 ATOM 2480 C CB . ASP A 1 328 ? 44.337 122.397 -5.739 1.00 54.48 ? 314 ASP A CB 1 ATOM 2481 C CG . ASP A 1 328 ? 44.373 123.699 -6.498 1.00 61.83 ? 314 ASP A CG 1 ATOM 2482 O OD1 . ASP A 1 328 ? 44.072 124.762 -5.883 1.00 61.56 ? 314 ASP A OD1 1 ATOM 2483 O OD2 . ASP A 1 328 ? 44.666 123.659 -7.721 1.00 65.66 ? 314 ASP A OD2 1 ATOM 2484 N N . ARG A 1 329 ? 43.435 123.946 -2.549 1.00 54.44 ? 315 ARG A N 1 ATOM 2485 C CA . ARG A 1 329 ? 42.343 124.612 -1.837 1.00 54.82 ? 315 ARG A CA 1 ATOM 2486 C C . ARG A 1 329 ? 41.721 125.732 -2.683 1.00 62.94 ? 315 ARG A C 1 ATOM 2487 O O . ARG A 1 329 ? 40.524 126.002 -2.549 1.00 64.67 ? 315 ARG A O 1 ATOM 2488 C CB . ARG A 1 329 ? 42.790 125.159 -0.463 1.00 53.08 ? 315 ARG A CB 1 ATOM 2489 C CG . ARG A 1 329 ? 42.902 124.137 0.661 1.00 65.15 ? 315 ARG A CG 1 ATOM 2490 C CD . ARG A 1 329 ? 41.557 123.599 1.105 1.00 79.10 ? 315 ARG A CD 1 ATOM 2491 N NE . ARG A 1 329 ? 40.638 124.619 1.625 1.00 87.64 ? 315 ARG A NE 1 ATOM 2492 C CZ . ARG A 1 329 ? 40.580 125.014 2.896 1.00 96.23 ? 315 ARG A CZ 1 ATOM 2493 N NH1 . ARG A 1 329 ? 41.416 124.508 3.796 1.00 86.59 ? 315 ARG A NH1 1 ATOM 2494 N NH2 . ARG A 1 329 ? 39.694 125.923 3.274 1.00 72.93 ? 315 ARG A NH2 1 ATOM 2495 N N . ARG A 1 330 ? 42.529 126.385 -3.534 1.00 59.58 ? 316 ARG A N 1 ATOM 2496 C CA . ARG A 1 330 ? 42.077 127.458 -4.407 1.00 59.26 ? 316 ARG A CA 1 ATOM 2497 C C . ARG A 1 330 ? 41.044 126.966 -5.442 1.00 62.02 ? 316 ARG A C 1 ATOM 2498 O O . ARG A 1 330 ? 40.057 127.659 -5.680 1.00 62.76 ? 316 ARG A O 1 ATOM 2499 C CB . ARG A 1 330 ? 43.276 128.123 -5.103 1.00 60.43 ? 316 ARG A CB 1 ATOM 2500 C CG . ARG A 1 330 ? 42.902 129.235 -6.083 1.00 71.54 ? 316 ARG A CG 1 ATOM 2501 C CD . ARG A 1 330 ? 44.104 130.082 -6.438 1.00 92.46 ? 316 ARG A CD 1 ATOM 2502 N NE . ARG A 1 330 ? 43.860 130.918 -7.614 1.00 109.48 ? 316 ARG A NE 1 ATOM 2503 C CZ . ARG A 1 330 ? 43.520 132.200 -7.564 1.00 123.86 ? 316 ARG A CZ 1 ATOM 2504 N NH1 . ARG A 1 330 ? 43.402 132.817 -6.393 1.00 112.68 ? 316 ARG A NH1 1 ATOM 2505 N NH2 . ARG A 1 330 ? 43.312 132.882 -8.683 1.00 104.84 ? 316 ARG A NH2 1 ATOM 2506 N N . ASN A 1 331 ? 41.250 125.781 -6.029 1.00 55.80 ? 317 ASN A N 1 ATOM 2507 C CA . ASN A 1 331 ? 40.366 125.276 -7.073 1.00 53.76 ? 317 ASN A CA 1 ATOM 2508 C C . ASN A 1 331 ? 39.542 124.057 -6.688 1.00 57.37 ? 317 ASN A C 1 ATOM 2509 O O . ASN A 1 331 ? 38.911 123.464 -7.566 1.00 58.34 ? 317 ASN A O 1 ATOM 2510 C CB . ASN A 1 331 ? 41.189 124.998 -8.324 1.00 51.37 ? 317 ASN A CB 1 ATOM 2511 C CG . ASN A 1 331 ? 41.933 126.201 -8.856 1.00 72.14 ? 317 ASN A CG 1 ATOM 2512 O OD1 . ASN A 1 331 ? 41.382 127.292 -9.049 1.00 66.47 ? 317 ASN A OD1 1 ATOM 2513 N ND2 . ASN A 1 331 ? 43.206 126.033 -9.140 1.00 66.06 ? 317 ASN A ND2 1 ATOM 2514 N N . ASN A 1 332 ? 39.524 123.690 -5.397 1.00 54.01 ? 318 ASN A N 1 ATOM 2515 C CA . ASN A 1 332 ? 38.828 122.511 -4.854 1.00 55.14 ? 318 ASN A CA 1 ATOM 2516 C C . ASN A 1 332 ? 39.017 121.274 -5.725 1.00 61.78 ? 318 ASN A C 1 ATOM 2517 O O . ASN A 1 332 ? 38.058 120.745 -6.300 1.00 62.58 ? 318 ASN A O 1 ATOM 2518 C CB . ASN A 1 332 ? 37.359 122.781 -4.550 1.00 58.26 ? 318 ASN A CB 1 ATOM 2519 C CG . ASN A 1 332 ? 37.171 123.719 -3.382 1.00 88.96 ? 318 ASN A CG 1 ATOM 2520 O OD1 . ASN A 1 332 ? 36.920 124.915 -3.562 1.00 91.61 ? 318 ASN A OD1 1 ATOM 2521 N ND2 . ASN A 1 332 ? 37.316 123.207 -2.159 1.00 75.62 ? 318 ASN A ND2 1 ATOM 2522 N N . ARG A 1 333 ? 40.290 120.837 -5.841 1.00 58.00 ? 319 ARG A N 1 ATOM 2523 C CA . ARG A 1 333 ? 40.694 119.687 -6.654 1.00 56.54 ? 319 ARG A CA 1 ATOM 2524 C C . ARG A 1 333 ? 41.964 119.030 -6.087 1.00 59.54 ? 319 ARG A C 1 ATOM 2525 O O . ARG A 1 333 ? 42.690 119.658 -5.308 1.00 60.36 ? 319 ARG A O 1 ATOM 2526 C CB . ARG A 1 333 ? 40.898 120.106 -8.135 1.00 51.86 ? 319 ARG A CB 1 ATOM 2527 C CG . ARG A 1 333 ? 41.960 121.180 -8.318 1.00 54.78 ? 319 ARG A CG 1 ATOM 2528 C CD . ARG A 1 333 ? 42.194 121.502 -9.767 1.00 62.65 ? 319 ARG A CD 1 ATOM 2529 N NE . ARG A 1 333 ? 43.396 122.326 -9.941 1.00 61.15 ? 319 ARG A NE 1 ATOM 2530 C CZ . ARG A 1 333 ? 43.950 122.596 -11.117 1.00 65.00 ? 319 ARG A CZ 1 ATOM 2531 N NH1 . ARG A 1 333 ? 43.414 122.121 -12.241 1.00 46.56 ? 319 ARG A NH1 1 ATOM 2532 N NH2 . ARG A 1 333 ? 45.039 123.347 -11.184 1.00 41.13 ? 319 ARG A NH2 1 ATOM 2533 N N . ILE A 1 334 ? 42.226 117.776 -6.513 1.00 51.62 ? 320 ILE A N 1 ATOM 2534 C CA . ILE A 1 334 ? 43.393 116.987 -6.152 1.00 48.82 ? 320 ILE A CA 1 ATOM 2535 C C . ILE A 1 334 ? 44.141 116.636 -7.441 1.00 51.86 ? 320 ILE A C 1 ATOM 2536 O O . ILE A 1 334 ? 43.545 116.083 -8.359 1.00 48.62 ? 320 ILE A O 1 ATOM 2537 C CB . ILE A 1 334 ? 42.985 115.695 -5.359 1.00 50.68 ? 320 ILE A CB 1 ATOM 2538 C CG1 . ILE A 1 334 ? 42.343 116.044 -3.990 1.00 49.45 ? 320 ILE A CG1 1 ATOM 2539 C CG2 . ILE A 1 334 ? 44.168 114.707 -5.207 1.00 50.71 ? 320 ILE A CG2 1 ATOM 2540 C CD1 . ILE A 1 334 ? 41.635 114.960 -3.406 1.00 42.77 ? 320 ILE A CD1 1 ATOM 2541 N N . GLY A 1 335 ? 45.445 116.907 -7.463 1.00 50.56 ? 321 GLY A N 1 ATOM 2542 C CA . GLY A 1 335 ? 46.312 116.555 -8.579 1.00 50.39 ? 321 GLY A CA 1 ATOM 2543 C C . GLY A 1 335 ? 47.189 115.366 -8.273 1.00 53.89 ? 321 GLY A C 1 ATOM 2544 O O . GLY A 1 335 ? 47.646 115.225 -7.139 1.00 55.06 ? 321 GLY A O 1 ATOM 2545 N N . PHE A 1 336 ? 47.416 114.492 -9.265 1.00 49.38 ? 322 PHE A N 1 ATOM 2546 C CA . PHE A 1 336 ? 48.296 113.322 -9.109 1.00 48.67 ? 322 PHE A CA 1 ATOM 2547 C C . PHE A 1 336 ? 49.354 113.245 -10.190 1.00 50.95 ? 322 PHE A C 1 ATOM 2548 O O . PHE A 1 336 ? 49.073 113.440 -11.369 1.00 51.53 ? 322 PHE A O 1 ATOM 2549 C CB . PHE A 1 336 ? 47.519 111.994 -9.132 1.00 50.19 ? 322 PHE A CB 1 ATOM 2550 C CG . PHE A 1 336 ? 46.554 111.738 -8.016 1.00 51.62 ? 322 PHE A CG 1 ATOM 2551 C CD1 . PHE A 1 336 ? 47.003 111.576 -6.711 1.00 55.64 ? 322 PHE A CD1 1 ATOM 2552 C CD2 . PHE A 1 336 ? 45.201 111.573 -8.278 1.00 54.10 ? 322 PHE A CD2 1 ATOM 2553 C CE1 . PHE A 1 336 ? 46.105 111.307 -5.677 1.00 56.50 ? 322 PHE A CE1 1 ATOM 2554 C CE2 . PHE A 1 336 ? 44.301 111.306 -7.247 1.00 57.07 ? 322 PHE A CE2 1 ATOM 2555 C CZ . PHE A 1 336 ? 44.760 111.166 -5.955 1.00 55.39 ? 322 PHE A CZ 1 ATOM 2556 N N . ALA A 1 337 ? 50.557 112.910 -9.808 1.00 45.73 ? 323 ALA A N 1 ATOM 2557 C CA . ALA A 1 337 ? 51.631 112.693 -10.772 1.00 44.96 ? 323 ALA A CA 1 ATOM 2558 C C . ALA A 1 337 ? 52.423 111.497 -10.278 1.00 48.62 ? 323 ALA A C 1 ATOM 2559 O O . ALA A 1 337 ? 52.345 111.161 -9.091 1.00 49.32 ? 323 ALA A O 1 ATOM 2560 C CB . ALA A 1 337 ? 52.515 113.933 -10.925 1.00 45.18 ? 323 ALA A CB 1 ATOM 2561 N N . LEU A 1 338 ? 53.131 110.826 -11.182 1.00 44.13 ? 324 LEU A N 1 ATOM 2562 C CA . LEU A 1 338 ? 53.938 109.668 -10.842 1.00 44.00 ? 324 LEU A CA 1 ATOM 2563 C C . LEU A 1 338 ? 55.111 110.105 -9.926 1.00 48.94 ? 324 LEU A C 1 ATOM 2564 O O . LEU A 1 338 ? 55.856 111.030 -10.273 1.00 48.64 ? 324 LEU A O 1 ATOM 2565 C CB . LEU A 1 338 ? 54.414 109.020 -12.136 1.00 43.62 ? 324 LEU A CB 1 ATOM 2566 C CG . LEU A 1 338 ? 55.149 107.705 -12.029 1.00 49.76 ? 324 LEU A CG 1 ATOM 2567 C CD1 . LEU A 1 338 ? 54.254 106.570 -11.423 1.00 49.22 ? 324 LEU A CD1 1 ATOM 2568 C CD2 . LEU A 1 338 ? 55.751 107.337 -13.390 1.00 53.45 ? 324 LEU A CD2 1 ATOM 2569 N N . ALA A 1 339 ? 55.208 109.493 -8.726 1.00 45.18 ? 325 ALA A N 1 ATOM 2570 C CA . ALA A 1 339 ? 56.257 109.826 -7.774 1.00 44.90 ? 325 ALA A CA 1 ATOM 2571 C C . ALA A 1 339 ? 57.642 109.357 -8.249 1.00 51.65 ? 325 ALA A C 1 ATOM 2572 O O . ALA A 1 339 ? 57.795 108.301 -8.874 1.00 52.85 ? 325 ALA A O 1 ATOM 2573 C CB . ALA A 1 339 ? 55.914 109.298 -6.389 1.00 45.44 ? 325 ALA A CB 1 ATOM 2574 N N . ARG A 1 340 ? 58.610 110.229 -8.086 1.00 48.60 ? 326 ARG A N 1 ATOM 2575 C CA . ARG A 1 340 ? 60.002 110.066 -8.493 1.00 47.09 ? 326 ARG A CA 1 ATOM 2576 C C . ARG A 1 340 ? 60.820 109.808 -7.205 1.00 63.93 ? 326 ARG A C 1 ATOM 2577 O O . ARG A 1 340 ? 61.300 108.660 -7.073 1.00 73.73 ? 326 ARG A O 1 ATOM 2578 C CB . ARG A 1 340 ? 60.406 111.381 -9.187 1.00 42.75 ? 326 ARG A CB 1 ATOM 2579 C CG . ARG A 1 340 ? 61.703 111.425 -9.874 1.00 34.59 ? 326 ARG A CG 1 ATOM 2580 C CD . ARG A 1 340 ? 61.882 112.838 -10.373 1.00 43.75 ? 326 ARG A CD 1 ATOM 2581 N NE . ARG A 1 340 ? 61.992 112.900 -11.831 1.00 65.91 ? 326 ARG A NE 1 ATOM 2582 C CZ . ARG A 1 340 ? 61.851 114.019 -12.540 1.00 92.49 ? 326 ARG A CZ 1 ATOM 2583 N NH1 . ARG A 1 340 ? 61.590 115.172 -11.933 1.00 91.65 ? 326 ARG A NH1 1 ATOM 2584 N NH2 . ARG A 1 340 ? 61.948 113.991 -13.859 1.00 72.79 ? 326 ARG A NH2 1 ATOM 2585 O OXT . ARG A 1 340 ? 60.895 110.700 -6.302 1.00 66.10 ? 326 ARG A OXT 1 ATOM 2586 N N . LEU B 1 1 ? 71.700 116.002 -33.104 1.00 82.96 ? -5 LEU B N 1 ATOM 2587 C CA . LEU B 1 1 ? 71.184 115.678 -31.773 1.00 83.24 ? -5 LEU B CA 1 ATOM 2588 C C . LEU B 1 1 ? 70.802 116.941 -30.974 1.00 88.16 ? -5 LEU B C 1 ATOM 2589 O O . LEU B 1 1 ? 71.595 117.892 -30.876 1.00 87.55 ? -5 LEU B O 1 ATOM 2590 C CB . LEU B 1 1 ? 72.152 114.733 -30.978 1.00 83.09 ? -5 LEU B CB 1 ATOM 2591 C CG . LEU B 1 1 ? 72.191 114.772 -29.413 1.00 87.24 ? -5 LEU B CG 1 ATOM 2592 C CD1 . LEU B 1 1 ? 70.942 114.211 -28.790 1.00 86.44 ? -5 LEU B CD1 1 ATOM 2593 C CD2 . LEU B 1 1 ? 73.385 114.004 -28.871 1.00 90.52 ? -5 LEU B CD2 1 ATOM 2594 N N . THR B 1 2 ? 69.571 116.914 -30.393 1.00 84.44 ? -4 THR B N 1 ATOM 2595 C CA . THR B 1 2 ? 68.999 117.980 -29.554 1.00 83.46 ? -4 THR B CA 1 ATOM 2596 C C . THR B 1 2 ? 68.950 117.522 -28.076 1.00 84.53 ? -4 THR B C 1 ATOM 2597 O O . THR B 1 2 ? 68.573 116.378 -27.784 1.00 84.58 ? -4 THR B O 1 ATOM 2598 C CB . THR B 1 2 ? 67.604 118.403 -30.077 1.00 89.70 ? -4 THR B CB 1 ATOM 2599 O OG1 . THR B 1 2 ? 67.656 118.644 -31.487 1.00 88.54 ? -4 THR B OG1 1 ATOM 2600 C CG2 . THR B 1 2 ? 67.047 119.632 -29.352 1.00 87.05 ? -4 THR B CG2 1 ATOM 2601 N N . LEU B 1 3 ? 69.345 118.419 -27.155 1.00 77.64 ? -3 LEU B N 1 ATOM 2602 C CA . LEU B 1 3 ? 69.326 118.149 -25.716 1.00 75.52 ? -3 LEU B CA 1 ATOM 2603 C C . LEU B 1 3 ? 68.337 119.081 -25.024 1.00 77.75 ? -3 LEU B C 1 ATOM 2604 O O . LEU B 1 3 ? 68.281 120.279 -25.328 1.00 78.57 ? -3 LEU B O 1 ATOM 2605 C CB . LEU B 1 3 ? 70.739 118.254 -25.069 1.00 74.85 ? -3 LEU B CB 1 ATOM 2606 C CG . LEU B 1 3 ? 71.776 117.142 -25.385 1.00 77.78 ? -3 LEU B CG 1 ATOM 2607 C CD1 . LEU B 1 3 ? 73.110 117.466 -24.778 1.00 76.89 ? -3 LEU B CD1 1 ATOM 2608 C CD2 . LEU B 1 3 ? 71.307 115.751 -24.909 1.00 78.36 ? -3 LEU B CD2 1 ATOM 2609 N N . GLY B 1 4 ? 67.542 118.512 -24.127 1.00 71.29 ? -2 GLY B N 1 ATOM 2610 C CA . GLY B 1 4 ? 66.544 119.245 -23.364 1.00 69.32 ? -2 GLY B CA 1 ATOM 2611 C C . GLY B 1 4 ? 66.978 119.476 -21.938 1.00 68.39 ? -2 GLY B C 1 ATOM 2612 O O . GLY B 1 4 ? 68.173 119.611 -21.669 1.00 66.54 ? -2 GLY B O 1 ATOM 2613 N N . ASN B 1 5 ? 66.001 119.523 -21.023 1.00 63.36 ? -1 ASN B N 1 ATOM 2614 C CA . ASN B 1 5 ? 66.225 119.752 -19.597 1.00 62.53 ? -1 ASN B CA 1 ATOM 2615 C C . ASN B 1 5 ? 65.451 118.697 -18.762 1.00 63.12 ? -1 ASN B C 1 ATOM 2616 O O . ASN B 1 5 ? 65.103 118.941 -17.597 1.00 62.32 ? -1 ASN B O 1 ATOM 2617 C CB . ASN B 1 5 ? 65.797 121.194 -19.239 1.00 64.38 ? -1 ASN B CB 1 ATOM 2618 C CG . ASN B 1 5 ? 66.481 121.748 -17.999 1.00 112.68 ? -1 ASN B CG 1 ATOM 2619 O OD1 . ASN B 1 5 ? 67.709 121.942 -17.954 1.00 112.40 ? -1 ASN B OD1 1 ATOM 2620 N ND2 . ASN B 1 5 ? 65.694 122.035 -16.963 1.00 106.16 ? -1 ASN B ND2 1 ATOM 2621 N N . THR B 1 6 ? 65.210 117.510 -19.356 1.00 56.06 ? 0 THR B N 1 ATOM 2622 C CA . THR B 1 6 ? 64.423 116.483 -18.702 1.00 54.86 ? 0 THR B CA 1 ATOM 2623 C C . THR B 1 6 ? 65.197 115.186 -18.430 1.00 56.66 ? 0 THR B C 1 ATOM 2624 O O . THR B 1 6 ? 66.068 114.776 -19.201 1.00 54.71 ? 0 THR B O 1 ATOM 2625 C CB . THR B 1 6 ? 63.121 116.268 -19.533 1.00 62.29 ? 0 THR B CB 1 ATOM 2626 O OG1 . THR B 1 6 ? 62.102 117.123 -19.018 1.00 69.69 ? 0 THR B OG1 1 ATOM 2627 C CG2 . THR B 1 6 ? 62.609 114.809 -19.563 1.00 55.98 ? 0 THR B CG2 1 ATOM 2628 N N . THR B 1 7 ? 64.835 114.550 -17.305 1.00 52.44 ? 1 THR B N 1 ATOM 2629 C CA . THR B 1 7 ? 65.254 113.213 -16.883 1.00 51.49 ? 1 THR B CA 1 ATOM 2630 C C . THR B 1 7 ? 63.975 112.431 -16.538 1.00 52.34 ? 1 THR B C 1 ATOM 2631 O O . THR B 1 7 ? 63.002 113.039 -16.094 1.00 50.49 ? 1 THR B O 1 ATOM 2632 C CB . THR B 1 7 ? 66.236 113.234 -15.691 1.00 58.09 ? 1 THR B CB 1 ATOM 2633 O OG1 . THR B 1 7 ? 65.602 113.812 -14.548 1.00 61.47 ? 1 THR B OG1 1 ATOM 2634 C CG2 . THR B 1 7 ? 67.563 113.925 -16.022 1.00 55.63 ? 1 THR B CG2 1 ATOM 2635 N N . SER B 1 8 ? 63.965 111.097 -16.754 1.00 47.73 ? 2 SER B N 1 ATOM 2636 C CA . SER B 1 8 ? 62.819 110.242 -16.412 1.00 47.35 ? 2 SER B CA 1 ATOM 2637 C C . SER B 1 8 ? 63.273 109.025 -15.629 1.00 51.82 ? 2 SER B C 1 ATOM 2638 O O . SER B 1 8 ? 64.144 108.285 -16.097 1.00 52.01 ? 2 SER B O 1 ATOM 2639 C CB . SER B 1 8 ? 62.066 109.794 -17.658 1.00 50.54 ? 2 SER B CB 1 ATOM 2640 O OG . SER B 1 8 ? 60.933 109.010 -17.310 1.00 52.97 ? 2 SER B OG 1 ATOM 2641 N N . SER B 1 9 ? 62.679 108.795 -14.452 1.00 47.59 ? 3 SER B N 1 ATOM 2642 C CA . SER B 1 9 ? 63.073 107.632 -13.670 1.00 46.90 ? 3 SER B CA 1 ATOM 2643 C C . SER B 1 9 ? 62.011 106.547 -13.628 1.00 49.80 ? 3 SER B C 1 ATOM 2644 O O . SER B 1 9 ? 60.821 106.843 -13.501 1.00 50.10 ? 3 SER B O 1 ATOM 2645 C CB . SER B 1 9 ? 63.508 108.029 -12.255 1.00 50.14 ? 3 SER B CB 1 ATOM 2646 O OG . SER B 1 9 ? 62.440 108.096 -11.321 1.00 55.77 ? 3 SER B OG 1 ATOM 2647 N N . VAL B 1 10 ? 62.441 105.292 -13.696 1.00 45.19 ? 4 VAL B N 1 ATOM 2648 C CA . VAL B 1 10 ? 61.547 104.146 -13.540 1.00 44.24 ? 4 VAL B CA 1 ATOM 2649 C C . VAL B 1 10 ? 61.997 103.373 -12.301 1.00 46.60 ? 4 VAL B C 1 ATOM 2650 O O . VAL B 1 10 ? 63.162 102.966 -12.228 1.00 46.58 ? 4 VAL B O 1 ATOM 2651 C CB . VAL B 1 10 ? 61.491 103.245 -14.789 1.00 47.44 ? 4 VAL B CB 1 ATOM 2652 C CG1 . VAL B 1 10 ? 60.628 102.020 -14.545 1.00 46.69 ? 4 VAL B CG1 1 ATOM 2653 C CG2 . VAL B 1 10 ? 60.992 104.012 -15.999 1.00 46.99 ? 4 VAL B CG2 1 ATOM 2654 N N . ILE B 1 11 ? 61.087 103.198 -11.330 1.00 41.62 ? 5 ILE B N 1 ATOM 2655 C CA . ILE B 1 11 ? 61.338 102.403 -10.131 1.00 41.63 ? 5 ILE B CA 1 ATOM 2656 C C . ILE B 1 11 ? 61.286 100.897 -10.534 1.00 43.93 ? 5 ILE B C 1 ATOM 2657 O O . ILE B 1 11 ? 60.431 100.501 -11.324 1.00 44.29 ? 5 ILE B O 1 ATOM 2658 C CB . ILE B 1 11 ? 60.362 102.756 -8.979 1.00 45.44 ? 5 ILE B CB 1 ATOM 2659 C CG1 . ILE B 1 11 ? 60.536 104.217 -8.452 1.00 47.28 ? 5 ILE B CG1 1 ATOM 2660 C CG2 . ILE B 1 11 ? 60.409 101.747 -7.836 1.00 45.27 ? 5 ILE B CG2 1 ATOM 2661 C CD1 . ILE B 1 11 ? 61.948 104.804 -8.310 1.00 63.46 ? 5 ILE B CD1 1 ATOM 2662 N N . LEU B 1 12 ? 62.223 100.094 -10.027 1.00 36.88 ? 6 LEU B N 1 ATOM 2663 C CA . LEU B 1 12 ? 62.304 98.674 -10.348 1.00 35.89 ? 6 LEU B CA 1 ATOM 2664 C C . LEU B 1 12 ? 61.994 97.773 -9.158 1.00 40.58 ? 6 LEU B C 1 ATOM 2665 O O . LEU B 1 12 ? 62.184 98.139 -7.991 1.00 38.83 ? 6 LEU B O 1 ATOM 2666 C CB . LEU B 1 12 ? 63.694 98.275 -10.912 1.00 35.26 ? 6 LEU B CB 1 ATOM 2667 C CG . LEU B 1 12 ? 64.302 99.103 -12.041 1.00 38.31 ? 6 LEU B CG 1 ATOM 2668 C CD1 . LEU B 1 12 ? 65.607 98.497 -12.468 1.00 36.37 ? 6 LEU B CD1 1 ATOM 2669 C CD2 . LEU B 1 12 ? 63.349 99.234 -13.225 1.00 37.86 ? 6 LEU B CD2 1 ATOM 2670 N N . THR B 1 13 ? 61.553 96.560 -9.485 1.00 36.96 ? 7 THR B N 1 ATOM 2671 C CA . THR B 1 13 ? 61.262 95.519 -8.525 1.00 35.62 ? 7 THR B CA 1 ATOM 2672 C C . THR B 1 13 ? 62.421 94.538 -8.542 1.00 37.38 ? 7 THR B C 1 ATOM 2673 O O . THR B 1 13 ? 62.847 94.112 -9.604 1.00 34.62 ? 7 THR B O 1 ATOM 2674 C CB . THR B 1 13 ? 59.921 94.888 -8.868 1.00 37.02 ? 7 THR B CB 1 ATOM 2675 O OG1 . THR B 1 13 ? 58.920 95.906 -8.781 1.00 43.19 ? 7 THR B OG1 1 ATOM 2676 C CG2 . THR B 1 13 ? 59.568 93.722 -7.969 1.00 26.54 ? 7 THR B CG2 1 ATOM 2677 N N . ASN B 1 14 ? 62.949 94.212 -7.371 1.00 36.64 ? 8 ASN B N 1 ATOM 2678 C CA . ASN B 1 14 ? 64.021 93.236 -7.228 1.00 36.87 ? 8 ASN B CA 1 ATOM 2679 C C . ASN B 1 14 ? 63.394 91.925 -6.810 1.00 43.86 ? 8 ASN B C 1 ATOM 2680 O O . ASN B 1 14 ? 62.962 91.785 -5.658 1.00 45.39 ? 8 ASN B O 1 ATOM 2681 C CB . ASN B 1 14 ? 65.052 93.682 -6.183 1.00 33.19 ? 8 ASN B CB 1 ATOM 2682 C CG . ASN B 1 14 ? 66.135 92.676 -5.866 1.00 44.51 ? 8 ASN B CG 1 ATOM 2683 O OD1 . ASN B 1 14 ? 66.116 91.524 -6.286 1.00 33.55 ? 8 ASN B OD1 1 ATOM 2684 N ND2 . ASN B 1 14 ? 67.116 93.098 -5.116 1.00 37.00 ? 8 ASN B ND2 1 ATOM 2685 N N . TYR B 1 15 ? 63.357 90.961 -7.737 1.00 40.21 ? 9 TYR B N 1 ATOM 2686 C CA . TYR B 1 15 ? 62.882 89.622 -7.432 1.00 40.60 ? 9 TYR B CA 1 ATOM 2687 C C . TYR B 1 15 ? 64.065 88.681 -7.165 1.00 46.55 ? 9 TYR B C 1 ATOM 2688 O O . TYR B 1 15 ? 64.788 88.343 -8.105 1.00 46.97 ? 9 TYR B O 1 ATOM 2689 C CB . TYR B 1 15 ? 61.985 89.062 -8.531 1.00 41.53 ? 9 TYR B CB 1 ATOM 2690 C CG . TYR B 1 15 ? 61.607 87.613 -8.305 1.00 42.29 ? 9 TYR B CG 1 ATOM 2691 C CD1 . TYR B 1 15 ? 60.687 87.256 -7.323 1.00 43.60 ? 9 TYR B CD1 1 ATOM 2692 C CD2 . TYR B 1 15 ? 62.151 86.601 -9.089 1.00 43.38 ? 9 TYR B CD2 1 ATOM 2693 C CE1 . TYR B 1 15 ? 60.327 85.927 -7.119 1.00 43.27 ? 9 TYR B CE1 1 ATOM 2694 C CE2 . TYR B 1 15 ? 61.784 85.270 -8.908 1.00 44.36 ? 9 TYR B CE2 1 ATOM 2695 C CZ . TYR B 1 15 ? 60.884 84.935 -7.909 1.00 53.48 ? 9 TYR B CZ 1 ATOM 2696 O OH . TYR B 1 15 ? 60.537 83.619 -7.722 1.00 57.57 ? 9 TYR B OH 1 ATOM 2697 N N . MET B 1 16 ? 64.266 88.284 -5.872 1.00 41.89 ? 10 MET B N 1 ATOM 2698 C CA . MET B 1 16 ? 65.265 87.331 -5.380 1.00 40.71 ? 10 MET B CA 1 ATOM 2699 C C . MET B 1 16 ? 66.712 87.619 -5.767 1.00 45.10 ? 10 MET B C 1 ATOM 2700 O O . MET B 1 16 ? 67.532 86.679 -5.828 1.00 43.89 ? 10 MET B O 1 ATOM 2701 C CB . MET B 1 16 ? 64.952 85.920 -5.894 1.00 43.07 ? 10 MET B CB 1 ATOM 2702 C CG . MET B 1 16 ? 63.634 85.332 -5.479 1.00 46.64 ? 10 MET B CG 1 ATOM 2703 S SD . MET B 1 16 ? 63.686 83.531 -5.651 1.00 51.04 ? 10 MET B SD 1 ATOM 2704 C CE . MET B 1 16 ? 64.482 83.320 -7.249 1.00 47.93 ? 10 MET B CE 1 ATOM 2705 N N . ASP B 1 17 ? 67.036 88.880 -6.077 1.00 42.45 ? 11 ASP B N 1 ATOM 2706 C CA . ASP B 1 17 ? 68.370 89.278 -6.556 1.00 42.19 ? 11 ASP B CA 1 ATOM 2707 C C . ASP B 1 17 ? 68.703 88.713 -7.938 1.00 45.92 ? 11 ASP B C 1 ATOM 2708 O O . ASP B 1 17 ? 69.821 88.906 -8.386 1.00 46.83 ? 11 ASP B O 1 ATOM 2709 C CB . ASP B 1 17 ? 69.486 88.976 -5.533 1.00 43.91 ? 11 ASP B CB 1 ATOM 2710 C CG . ASP B 1 17 ? 69.733 90.074 -4.507 1.00 61.04 ? 11 ASP B CG 1 ATOM 2711 O OD1 . ASP B 1 17 ? 69.007 91.093 -4.532 1.00 60.95 ? 11 ASP B OD1 1 ATOM 2712 O OD2 . ASP B 1 17 ? 70.677 89.933 -3.708 1.00 73.27 ? 11 ASP B OD2 1 ATOM 2713 N N . THR B 1 18 ? 67.729 88.063 -8.631 1.00 41.65 ? 12 THR B N 1 ATOM 2714 C CA . THR B 1 18 ? 67.918 87.486 -9.966 1.00 40.91 ? 12 THR B CA 1 ATOM 2715 C C . THR B 1 18 ? 67.182 88.218 -11.071 1.00 44.06 ? 12 THR B C 1 ATOM 2716 O O . THR B 1 18 ? 67.655 88.209 -12.199 1.00 45.50 ? 12 THR B O 1 ATOM 2717 C CB . THR B 1 18 ? 67.588 85.998 -10.014 1.00 47.00 ? 12 THR B CB 1 ATOM 2718 O OG1 . THR B 1 18 ? 66.232 85.789 -9.630 1.00 56.75 ? 12 THR B OG1 1 ATOM 2719 C CG2 . THR B 1 18 ? 68.524 85.172 -9.181 1.00 38.48 ? 12 THR B CG2 1 ATOM 2720 N N . GLN B 1 19 ? 66.030 88.816 -10.787 1.00 38.94 ? 13 GLN B N 1 ATOM 2721 C CA . GLN B 1 19 ? 65.255 89.525 -11.816 1.00 38.30 ? 13 GLN B CA 1 ATOM 2722 C C . GLN B 1 19 ? 64.924 90.909 -11.354 1.00 37.62 ? 13 GLN B C 1 ATOM 2723 O O . GLN B 1 19 ? 64.423 91.046 -10.247 1.00 36.59 ? 13 GLN B O 1 ATOM 2724 C CB . GLN B 1 19 ? 63.934 88.781 -12.133 1.00 40.45 ? 13 GLN B CB 1 ATOM 2725 C CG . GLN B 1 19 ? 64.116 87.351 -12.616 1.00 51.20 ? 13 GLN B CG 1 ATOM 2726 C CD . GLN B 1 19 ? 62.780 86.688 -12.868 1.00 58.02 ? 13 GLN B CD 1 ATOM 2727 O OE1 . GLN B 1 19 ? 61.803 87.300 -13.331 1.00 48.32 ? 13 GLN B OE1 1 ATOM 2728 N NE2 . GLN B 1 19 ? 62.736 85.394 -12.599 1.00 45.94 ? 13 GLN B NE2 1 ATOM 2729 N N . TYR B 1 20 ? 65.174 91.933 -12.202 1.00 33.97 ? 14 TYR B N 1 ATOM 2730 C CA . TYR B 1 20 ? 64.886 93.359 -11.930 1.00 33.10 ? 14 TYR B CA 1 ATOM 2731 C C . TYR B 1 20 ? 64.007 93.890 -13.041 1.00 39.67 ? 14 TYR B C 1 ATOM 2732 O O . TYR B 1 20 ? 64.378 93.788 -14.223 1.00 39.55 ? 14 TYR B O 1 ATOM 2733 C CB . TYR B 1 20 ? 66.184 94.194 -11.839 1.00 32.55 ? 14 TYR B CB 1 ATOM 2734 C CG . TYR B 1 20 ? 67.041 93.862 -10.633 1.00 30.73 ? 14 TYR B CG 1 ATOM 2735 C CD1 . TYR B 1 20 ? 67.872 92.739 -10.627 1.00 30.88 ? 14 TYR B CD1 1 ATOM 2736 C CD2 . TYR B 1 20 ? 67.028 94.673 -9.504 1.00 31.55 ? 14 TYR B CD2 1 ATOM 2737 C CE1 . TYR B 1 20 ? 68.666 92.432 -9.522 1.00 31.86 ? 14 TYR B CE1 1 ATOM 2738 C CE2 . TYR B 1 20 ? 67.831 94.385 -8.398 1.00 33.37 ? 14 TYR B CE2 1 ATOM 2739 C CZ . TYR B 1 20 ? 68.646 93.263 -8.412 1.00 40.96 ? 14 TYR B CZ 1 ATOM 2740 O OH . TYR B 1 20 ? 69.445 92.980 -7.335 1.00 46.60 ? 14 TYR B OH 1 ATOM 2741 N N . TYR B 1 21 ? 62.835 94.439 -12.701 1.00 36.65 ? 15 TYR B N 1 ATOM 2742 C CA . TYR B 1 21 ? 61.910 94.890 -13.747 1.00 36.95 ? 15 TYR B CA 1 ATOM 2743 C C . TYR B 1 21 ? 61.084 96.071 -13.312 1.00 44.70 ? 15 TYR B C 1 ATOM 2744 O O . TYR B 1 21 ? 60.735 96.185 -12.135 1.00 47.53 ? 15 TYR B O 1 ATOM 2745 C CB . TYR B 1 21 ? 60.991 93.719 -14.207 1.00 38.02 ? 15 TYR B CB 1 ATOM 2746 C CG . TYR B 1 21 ? 60.447 92.886 -13.063 1.00 37.91 ? 15 TYR B CG 1 ATOM 2747 C CD1 . TYR B 1 21 ? 61.162 91.803 -12.563 1.00 40.86 ? 15 TYR B CD1 1 ATOM 2748 C CD2 . TYR B 1 21 ? 59.248 93.220 -12.440 1.00 37.12 ? 15 TYR B CD2 1 ATOM 2749 C CE1 . TYR B 1 21 ? 60.713 91.093 -11.449 1.00 43.60 ? 15 TYR B CE1 1 ATOM 2750 C CE2 . TYR B 1 21 ? 58.777 92.501 -11.349 1.00 37.61 ? 15 TYR B CE2 1 ATOM 2751 C CZ . TYR B 1 21 ? 59.522 91.451 -10.843 1.00 51.16 ? 15 TYR B CZ 1 ATOM 2752 O OH . TYR B 1 21 ? 59.055 90.730 -9.774 1.00 61.91 ? 15 TYR B OH 1 ATOM 2753 N N . GLY B 1 22 ? 60.767 96.931 -14.264 1.00 40.73 ? 16 GLY B N 1 ATOM 2754 C CA . GLY B 1 22 ? 59.961 98.120 -14.039 1.00 40.30 ? 16 GLY B CA 1 ATOM 2755 C C . GLY B 1 22 ? 58.693 98.121 -14.844 1.00 43.93 ? 16 GLY B C 1 ATOM 2756 O O . GLY B 1 22 ? 58.420 97.166 -15.557 1.00 43.31 ? 16 GLY B O 1 ATOM 2757 N N . GLU B 1 23 ? 57.924 99.188 -14.751 1.00 40.82 ? 17 GLU B N 1 ATOM 2758 C CA . GLU B 1 23 ? 56.676 99.274 -15.478 1.00 42.04 ? 17 GLU B CA 1 ATOM 2759 C C . GLU B 1 23 ? 56.745 100.249 -16.643 1.00 47.21 ? 17 GLU B C 1 ATOM 2760 O O . GLU B 1 23 ? 57.419 101.273 -16.551 1.00 47.41 ? 17 GLU B O 1 ATOM 2761 C CB . GLU B 1 23 ? 55.524 99.652 -14.524 1.00 43.83 ? 17 GLU B CB 1 ATOM 2762 C CG . GLU B 1 23 ? 55.240 98.615 -13.442 1.00 61.33 ? 17 GLU B CG 1 ATOM 2763 C CD . GLU B 1 23 ? 55.281 99.145 -12.014 1.00 98.85 ? 17 GLU B CD 1 ATOM 2764 O OE1 . GLU B 1 23 ? 54.267 99.731 -11.564 1.00 88.70 ? 17 GLU B OE1 1 ATOM 2765 O OE2 . GLU B 1 23 ? 56.323 98.963 -11.340 1.00 98.91 ? 17 GLU B OE2 1 ATOM 2766 N N . ILE B 1 24 ? 56.064 99.900 -17.750 1.00 43.08 ? 18 ILE B N 1 ATOM 2767 C CA . ILE B 1 24 ? 55.819 100.724 -18.950 1.00 42.39 ? 18 ILE B CA 1 ATOM 2768 C C . ILE B 1 24 ? 54.321 100.622 -19.280 1.00 46.84 ? 18 ILE B C 1 ATOM 2769 O O . ILE B 1 24 ? 53.647 99.676 -18.851 1.00 42.94 ? 18 ILE B O 1 ATOM 2770 C CB . ILE B 1 24 ? 56.704 100.392 -20.176 1.00 44.69 ? 18 ILE B CB 1 ATOM 2771 C CG1 . ILE B 1 24 ? 56.448 98.951 -20.691 1.00 45.07 ? 18 ILE B CG1 1 ATOM 2772 C CG2 . ILE B 1 24 ? 58.181 100.671 -19.903 1.00 44.64 ? 18 ILE B CG2 1 ATOM 2773 C CD1 . ILE B 1 24 ? 56.806 98.698 -22.180 1.00 45.02 ? 18 ILE B CD1 1 ATOM 2774 N N . GLY B 1 25 ? 53.825 101.613 -19.998 1.00 48.11 ? 19 GLY B N 1 ATOM 2775 C CA . GLY B 1 25 ? 52.449 101.651 -20.485 1.00 49.43 ? 19 GLY B CA 1 ATOM 2776 C C . GLY B 1 25 ? 52.433 101.626 -22.005 1.00 54.44 ? 19 GLY B C 1 ATOM 2777 O O . GLY B 1 25 ? 53.255 102.285 -22.651 1.00 51.60 ? 19 GLY B O 1 ATOM 2778 N N . ILE B 1 26 ? 51.553 100.824 -22.588 1.00 55.03 ? 20 ILE B N 1 ATOM 2779 C CA . ILE B 1 26 ? 51.453 100.739 -24.050 1.00 56.52 ? 20 ILE B CA 1 ATOM 2780 C C . ILE B 1 26 ? 50.008 101.007 -24.477 1.00 64.94 ? 20 ILE B C 1 ATOM 2781 O O . ILE B 1 26 ? 49.077 100.348 -23.987 1.00 64.04 ? 20 ILE B O 1 ATOM 2782 C CB . ILE B 1 26 ? 52.024 99.411 -24.650 1.00 58.91 ? 20 ILE B CB 1 ATOM 2783 C CG1 . ILE B 1 26 ? 53.424 99.060 -24.081 1.00 59.24 ? 20 ILE B CG1 1 ATOM 2784 C CG2 . ILE B 1 26 ? 52.078 99.495 -26.181 1.00 59.37 ? 20 ILE B CG2 1 ATOM 2785 C CD1 . ILE B 1 26 ? 53.971 97.677 -24.445 1.00 57.18 ? 20 ILE B CD1 1 ATOM 2786 N N . GLY B 1 27 ? 49.850 101.982 -25.366 1.00 64.43 ? 21 GLY B N 1 ATOM 2787 C CA . GLY B 1 27 ? 48.562 102.344 -25.937 1.00 65.75 ? 21 GLY B CA 1 ATOM 2788 C C . GLY B 1 27 ? 47.799 103.464 -25.275 1.00 72.48 ? 21 GLY B C 1 ATOM 2789 O O . GLY B 1 27 ? 48.281 104.063 -24.316 1.00 73.41 ? 21 GLY B O 1 ATOM 2790 N N . THR B 1 28 ? 46.602 103.761 -25.820 1.00 69.68 ? 22 THR B N 1 ATOM 2791 C CA . THR B 1 28 ? 45.663 104.767 -25.323 1.00 69.16 ? 22 THR B CA 1 ATOM 2792 C C . THR B 1 28 ? 44.300 104.097 -25.109 1.00 74.21 ? 22 THR B C 1 ATOM 2793 O O . THR B 1 28 ? 43.647 103.734 -26.098 1.00 75.35 ? 22 THR B O 1 ATOM 2794 C CB . THR B 1 28 ? 45.581 105.974 -26.258 1.00 70.14 ? 22 THR B CB 1 ATOM 2795 O OG1 . THR B 1 28 ? 46.890 106.471 -26.487 1.00 66.39 ? 22 THR B OG1 1 ATOM 2796 C CG2 . THR B 1 28 ? 44.733 107.086 -25.692 1.00 68.78 ? 22 THR B CG2 1 ATOM 2797 N N . PRO B 1 29 ? 43.850 103.904 -23.844 1.00 70.22 ? 23 PRO B N 1 ATOM 2798 C CA . PRO B 1 29 ? 44.540 104.209 -22.569 1.00 69.35 ? 23 PRO B CA 1 ATOM 2799 C C . PRO B 1 29 ? 45.725 103.249 -22.337 1.00 73.44 ? 23 PRO B C 1 ATOM 2800 O O . PRO B 1 29 ? 45.754 102.166 -22.955 1.00 74.46 ? 23 PRO B O 1 ATOM 2801 C CB . PRO B 1 29 ? 43.429 104.024 -21.529 1.00 70.48 ? 23 PRO B CB 1 ATOM 2802 C CG . PRO B 1 29 ? 42.557 102.960 -22.110 1.00 75.42 ? 23 PRO B CG 1 ATOM 2803 C CD . PRO B 1 29 ? 42.560 103.225 -23.604 1.00 71.51 ? 23 PRO B CD 1 ATOM 2804 N N . PRO B 1 30 ? 46.726 103.605 -21.488 1.00 66.81 ? 24 PRO B N 1 ATOM 2805 C CA . PRO B 1 30 ? 47.867 102.695 -21.288 1.00 65.11 ? 24 PRO B CA 1 ATOM 2806 C C . PRO B 1 30 ? 47.535 101.358 -20.638 1.00 67.64 ? 24 PRO B C 1 ATOM 2807 O O . PRO B 1 30 ? 46.785 101.301 -19.654 1.00 66.89 ? 24 PRO B O 1 ATOM 2808 C CB . PRO B 1 30 ? 48.806 103.504 -20.395 1.00 66.43 ? 24 PRO B CB 1 ATOM 2809 C CG . PRO B 1 30 ? 48.347 104.917 -20.526 1.00 71.01 ? 24 PRO B CG 1 ATOM 2810 C CD . PRO B 1 30 ? 46.887 104.832 -20.684 1.00 67.35 ? 24 PRO B CD 1 ATOM 2811 N N . GLN B 1 31 ? 48.109 100.284 -21.214 1.00 62.93 ? 25 GLN B N 1 ATOM 2812 C CA . GLN B 1 31 ? 48.059 98.903 -20.721 1.00 61.88 ? 25 GLN B CA 1 ATOM 2813 C C . GLN B 1 31 ? 49.445 98.738 -20.105 1.00 63.78 ? 25 GLN B C 1 ATOM 2814 O O . GLN B 1 31 ? 50.439 99.079 -20.751 1.00 62.44 ? 25 GLN B O 1 ATOM 2815 C CB . GLN B 1 31 ? 47.857 97.911 -21.879 1.00 63.24 ? 25 GLN B CB 1 ATOM 2816 C CG . GLN B 1 31 ? 46.496 98.060 -22.563 1.00 75.51 ? 25 GLN B CG 1 ATOM 2817 C CD . GLN B 1 31 ? 46.338 97.213 -23.804 1.00 85.45 ? 25 GLN B CD 1 ATOM 2818 O OE1 . GLN B 1 31 ? 46.578 95.987 -23.810 1.00 75.63 ? 25 GLN B OE1 1 ATOM 2819 N NE2 . GLN B 1 31 ? 45.863 97.853 -24.871 1.00 77.86 ? 25 GLN B NE2 1 ATOM 2820 N N . THR B 1 32 ? 49.514 98.330 -18.831 1.00 59.33 ? 26 THR B N 1 ATOM 2821 C CA . THR B 1 32 ? 50.782 98.262 -18.107 1.00 57.49 ? 26 THR B CA 1 ATOM 2822 C C . THR B 1 32 ? 51.418 96.883 -18.108 1.00 58.21 ? 26 THR B C 1 ATOM 2823 O O . THR B 1 32 ? 50.750 95.870 -17.907 1.00 58.56 ? 26 THR B O 1 ATOM 2824 C CB . THR B 1 32 ? 50.638 98.813 -16.697 1.00 66.62 ? 26 THR B CB 1 ATOM 2825 O OG1 . THR B 1 32 ? 49.618 98.058 -16.040 1.00 74.98 ? 26 THR B OG1 1 ATOM 2826 C CG2 . THR B 1 32 ? 50.282 100.310 -16.681 1.00 59.96 ? 26 THR B CG2 1 ATOM 2827 N N . PHE B 1 33 ? 52.739 96.863 -18.321 1.00 51.64 ? 27 PHE B N 1 ATOM 2828 C CA . PHE B 1 33 ? 53.543 95.650 -18.374 1.00 49.98 ? 27 PHE B CA 1 ATOM 2829 C C . PHE B 1 33 ? 54.753 95.821 -17.525 1.00 52.13 ? 27 PHE B C 1 ATOM 2830 O O . PHE B 1 33 ? 55.271 96.937 -17.419 1.00 53.16 ? 27 PHE B O 1 ATOM 2831 C CB . PHE B 1 33 ? 53.985 95.365 -19.828 1.00 51.61 ? 27 PHE B CB 1 ATOM 2832 C CG . PHE B 1 33 ? 52.812 95.135 -20.747 1.00 52.72 ? 27 PHE B CG 1 ATOM 2833 C CD1 . PHE B 1 33 ? 52.243 96.195 -21.451 1.00 55.75 ? 27 PHE B CD1 1 ATOM 2834 C CD2 . PHE B 1 33 ? 52.222 93.884 -20.841 1.00 53.35 ? 27 PHE B CD2 1 ATOM 2835 C CE1 . PHE B 1 33 ? 51.121 96.000 -22.246 1.00 56.29 ? 27 PHE B CE1 1 ATOM 2836 C CE2 . PHE B 1 33 ? 51.101 93.693 -21.632 1.00 56.14 ? 27 PHE B CE2 1 ATOM 2837 C CZ . PHE B 1 33 ? 50.563 94.754 -22.332 1.00 54.86 ? 27 PHE B CZ 1 ATOM 2838 N N . LYS B 1 34 ? 55.192 94.722 -16.904 1.00 46.56 ? 28 LYS B N 1 ATOM 2839 C CA . LYS B 1 34 ? 56.426 94.624 -16.123 1.00 45.92 ? 28 LYS B CA 1 ATOM 2840 C C . LYS B 1 34 ? 57.493 94.216 -17.162 1.00 51.49 ? 28 LYS B C 1 ATOM 2841 O O . LYS B 1 34 ? 57.329 93.204 -17.843 1.00 50.91 ? 28 LYS B O 1 ATOM 2842 C CB . LYS B 1 34 ? 56.324 93.567 -15.002 1.00 46.14 ? 28 LYS B CB 1 ATOM 2843 C CG . LYS B 1 34 ? 55.235 93.837 -13.971 1.00 32.67 ? 28 LYS B CG 1 ATOM 2844 C CD . LYS B 1 34 ? 55.061 92.664 -13.020 1.00 42.56 ? 28 LYS B CD 1 ATOM 2845 C CE . LYS B 1 34 ? 53.696 92.718 -12.363 1.00 51.40 ? 28 LYS B CE 1 ATOM 2846 N NZ . LYS B 1 34 ? 53.488 91.643 -11.345 1.00 47.96 ? 28 LYS B NZ 1 ATOM 2847 N N . VAL B 1 35 ? 58.514 95.060 -17.371 1.00 48.26 ? 29 VAL B N 1 ATOM 2848 C CA . VAL B 1 35 ? 59.557 94.811 -18.379 1.00 47.69 ? 29 VAL B CA 1 ATOM 2849 C C . VAL B 1 35 ? 60.996 94.826 -17.786 1.00 50.32 ? 29 VAL B C 1 ATOM 2850 O O . VAL B 1 35 ? 61.266 95.500 -16.786 1.00 49.57 ? 29 VAL B O 1 ATOM 2851 C CB . VAL B 1 35 ? 59.437 95.757 -19.620 1.00 51.36 ? 29 VAL B CB 1 ATOM 2852 C CG1 . VAL B 1 35 ? 58.112 95.557 -20.350 1.00 51.91 ? 29 VAL B CG1 1 ATOM 2853 C CG2 . VAL B 1 35 ? 59.630 97.227 -19.247 1.00 50.62 ? 29 VAL B CG2 1 ATOM 2854 N N . VAL B 1 36 ? 61.902 94.078 -18.433 1.00 44.01 ? 30 VAL B N 1 ATOM 2855 C CA . VAL B 1 36 ? 63.309 94.066 -18.103 1.00 42.03 ? 30 VAL B CA 1 ATOM 2856 C C . VAL B 1 36 ? 63.955 95.106 -19.049 1.00 44.80 ? 30 VAL B C 1 ATOM 2857 O O . VAL B 1 36 ? 63.704 95.077 -20.274 1.00 44.89 ? 30 VAL B O 1 ATOM 2858 C CB . VAL B 1 36 ? 63.941 92.654 -18.262 1.00 44.54 ? 30 VAL B CB 1 ATOM 2859 C CG1 . VAL B 1 36 ? 65.470 92.717 -18.285 1.00 43.83 ? 30 VAL B CG1 1 ATOM 2860 C CG2 . VAL B 1 36 ? 63.492 91.731 -17.156 1.00 44.00 ? 30 VAL B CG2 1 ATOM 2861 N N . PHE B 1 37 ? 64.749 96.041 -18.478 1.00 36.74 ? 31 PHE B N 1 ATOM 2862 C CA . PHE B 1 37 ? 65.451 97.032 -19.290 1.00 35.35 ? 31 PHE B CA 1 ATOM 2863 C C . PHE B 1 37 ? 66.799 96.390 -19.489 1.00 42.05 ? 31 PHE B C 1 ATOM 2864 O O . PHE B 1 37 ? 67.576 96.272 -18.540 1.00 41.16 ? 31 PHE B O 1 ATOM 2865 C CB . PHE B 1 37 ? 65.501 98.397 -18.618 1.00 35.92 ? 31 PHE B CB 1 ATOM 2866 C CG . PHE B 1 37 ? 64.141 98.988 -18.401 1.00 36.39 ? 31 PHE B CG 1 ATOM 2867 C CD1 . PHE B 1 37 ? 63.394 98.664 -17.260 1.00 39.83 ? 31 PHE B CD1 1 ATOM 2868 C CD2 . PHE B 1 37 ? 63.603 99.876 -19.318 1.00 36.78 ? 31 PHE B CD2 1 ATOM 2869 C CE1 . PHE B 1 37 ? 62.124 99.224 -17.048 1.00 40.98 ? 31 PHE B CE1 1 ATOM 2870 C CE2 . PHE B 1 37 ? 62.341 100.446 -19.111 1.00 40.62 ? 31 PHE B CE2 1 ATOM 2871 C CZ . PHE B 1 37 ? 61.589 100.091 -17.996 1.00 40.18 ? 31 PHE B CZ 1 ATOM 2872 N N . ASP B 1 38 ? 67.006 95.835 -20.711 1.00 40.70 ? 32 ASP B N 1 ATOM 2873 C CA . ASP B 1 38 ? 68.137 94.982 -21.072 1.00 40.33 ? 32 ASP B CA 1 ATOM 2874 C C . ASP B 1 38 ? 69.134 95.623 -22.036 1.00 46.33 ? 32 ASP B C 1 ATOM 2875 O O . ASP B 1 38 ? 68.800 95.840 -23.189 1.00 48.93 ? 32 ASP B O 1 ATOM 2876 C CB . ASP B 1 38 ? 67.572 93.650 -21.616 1.00 41.31 ? 32 ASP B CB 1 ATOM 2877 C CG . ASP B 1 38 ? 68.588 92.675 -22.159 1.00 55.46 ? 32 ASP B CG 1 ATOM 2878 O OD1 . ASP B 1 38 ? 69.773 92.761 -21.761 1.00 56.52 ? 32 ASP B OD1 1 ATOM 2879 O OD2 . ASP B 1 38 ? 68.196 91.800 -22.947 1.00 62.16 ? 32 ASP B OD2 1 ATOM 2880 N N . THR B 1 39 ? 70.369 95.878 -21.574 1.00 42.03 ? 33 THR B N 1 ATOM 2881 C CA . THR B 1 39 ? 71.429 96.481 -22.399 1.00 41.40 ? 33 THR B CA 1 ATOM 2882 C C . THR B 1 39 ? 72.092 95.461 -23.343 1.00 45.58 ? 33 THR B C 1 ATOM 2883 O O . THR B 1 39 ? 72.842 95.843 -24.245 1.00 44.21 ? 33 THR B O 1 ATOM 2884 C CB . THR B 1 39 ? 72.459 97.241 -21.535 1.00 42.07 ? 33 THR B CB 1 ATOM 2885 O OG1 . THR B 1 39 ? 72.998 96.374 -20.536 1.00 41.34 ? 33 THR B OG1 1 ATOM 2886 C CG2 . THR B 1 39 ? 71.885 98.523 -20.932 1.00 31.17 ? 33 THR B CG2 1 ATOM 2887 N N . GLY B 1 40 ? 71.799 94.180 -23.129 1.00 43.49 ? 34 GLY B N 1 ATOM 2888 C CA . GLY B 1 40 ? 72.302 93.081 -23.951 1.00 42.74 ? 34 GLY B CA 1 ATOM 2889 C C . GLY B 1 40 ? 71.448 92.804 -25.179 1.00 46.65 ? 34 GLY B C 1 ATOM 2890 O O . GLY B 1 40 ? 71.786 91.902 -25.950 1.00 46.82 ? 34 GLY B O 1 ATOM 2891 N N . SER B 1 41 ? 70.311 93.553 -25.363 1.00 42.67 ? 35 SER B N 1 ATOM 2892 C CA . SER B 1 41 ? 69.378 93.416 -26.497 1.00 41.79 ? 35 SER B CA 1 ATOM 2893 C C . SER B 1 41 ? 68.766 94.760 -26.922 1.00 47.81 ? 35 SER B C 1 ATOM 2894 O O . SER B 1 41 ? 68.844 95.713 -26.159 1.00 48.58 ? 35 SER B O 1 ATOM 2895 C CB . SER B 1 41 ? 68.319 92.358 -26.219 1.00 42.62 ? 35 SER B CB 1 ATOM 2896 O OG . SER B 1 41 ? 67.347 92.808 -25.299 1.00 52.32 ? 35 SER B OG 1 ATOM 2897 N N . SER B 1 42 ? 68.210 94.867 -28.153 1.00 45.09 ? 36 SER B N 1 ATOM 2898 C CA . SER B 1 42 ? 67.763 96.159 -28.685 1.00 44.15 ? 36 SER B CA 1 ATOM 2899 C C . SER B 1 42 ? 66.317 96.235 -29.130 1.00 50.32 ? 36 SER B C 1 ATOM 2900 O O . SER B 1 42 ? 65.909 97.259 -29.698 1.00 49.68 ? 36 SER B O 1 ATOM 2901 C CB . SER B 1 42 ? 68.673 96.579 -29.830 1.00 47.33 ? 36 SER B CB 1 ATOM 2902 O OG . SER B 1 42 ? 70.045 96.417 -29.496 1.00 55.29 ? 36 SER B OG 1 ATOM 2903 N N . ASN B 1 43 ? 65.523 95.189 -28.843 1.00 49.62 ? 37 ASN B N 1 ATOM 2904 C CA . ASN B 1 43 ? 64.106 95.160 -29.221 1.00 49.93 ? 37 ASN B CA 1 ATOM 2905 C C . ASN B 1 43 ? 63.199 95.345 -28.022 1.00 56.13 ? 37 ASN B C 1 ATOM 2906 O O . ASN B 1 43 ? 63.575 94.984 -26.897 1.00 56.48 ? 37 ASN B O 1 ATOM 2907 C CB . ASN B 1 43 ? 63.746 93.841 -29.915 1.00 47.48 ? 37 ASN B CB 1 ATOM 2908 C CG . ASN B 1 43 ? 64.484 93.602 -31.195 1.00 70.51 ? 37 ASN B CG 1 ATOM 2909 O OD1 . ASN B 1 43 ? 65.602 93.078 -31.216 1.00 69.88 ? 37 ASN B OD1 1 ATOM 2910 N ND2 . ASN B 1 43 ? 63.856 93.956 -32.290 1.00 65.07 ? 37 ASN B ND2 1 ATOM 2911 N N . VAL B 1 44 ? 61.991 95.900 -28.281 1.00 51.79 ? 38 VAL B N 1 ATOM 2912 C CA . VAL B 1 44 ? 60.936 96.053 -27.289 1.00 50.80 ? 38 VAL B CA 1 ATOM 2913 C C . VAL B 1 44 ? 59.921 94.996 -27.639 1.00 56.98 ? 38 VAL B C 1 ATOM 2914 O O . VAL B 1 44 ? 59.560 94.865 -28.803 1.00 57.88 ? 38 VAL B O 1 ATOM 2915 C CB . VAL B 1 44 ? 60.286 97.452 -27.262 1.00 53.50 ? 38 VAL B CB 1 ATOM 2916 C CG1 . VAL B 1 44 ? 59.150 97.517 -26.233 1.00 52.76 ? 38 VAL B CG1 1 ATOM 2917 C CG2 . VAL B 1 44 ? 61.320 98.533 -26.981 1.00 53.10 ? 38 VAL B CG2 1 ATOM 2918 N N . TRP B 1 45 ? 59.485 94.214 -26.652 1.00 53.85 ? 39 TRP B N 1 ATOM 2919 C CA . TRP B 1 45 ? 58.468 93.199 -26.863 1.00 53.36 ? 39 TRP B CA 1 ATOM 2920 C C . TRP B 1 45 ? 57.683 92.921 -25.599 1.00 60.48 ? 39 TRP B C 1 ATOM 2921 O O . TRP B 1 45 ? 58.253 92.942 -24.513 1.00 60.60 ? 39 TRP B O 1 ATOM 2922 C CB . TRP B 1 45 ? 59.056 91.904 -27.467 1.00 50.82 ? 39 TRP B CB 1 ATOM 2923 C CG . TRP B 1 45 ? 59.867 91.046 -26.541 1.00 50.88 ? 39 TRP B CG 1 ATOM 2924 C CD1 . TRP B 1 45 ? 61.228 90.920 -26.522 1.00 53.49 ? 39 TRP B CD1 1 ATOM 2925 C CD2 . TRP B 1 45 ? 59.365 90.084 -25.605 1.00 50.37 ? 39 TRP B CD2 1 ATOM 2926 N NE1 . TRP B 1 45 ? 61.606 89.938 -25.634 1.00 52.10 ? 39 TRP B NE1 1 ATOM 2927 C CE2 . TRP B 1 45 ? 60.483 89.426 -25.038 1.00 53.71 ? 39 TRP B CE2 1 ATOM 2928 C CE3 . TRP B 1 45 ? 58.077 89.708 -25.192 1.00 51.37 ? 39 TRP B CE3 1 ATOM 2929 C CZ2 . TRP B 1 45 ? 60.351 88.450 -24.049 1.00 53.12 ? 39 TRP B CZ2 1 ATOM 2930 C CZ3 . TRP B 1 45 ? 57.947 88.726 -24.230 1.00 52.64 ? 39 TRP B CZ3 1 ATOM 2931 C CH2 . TRP B 1 45 ? 59.075 88.107 -23.669 1.00 53.40 ? 39 TRP B CH2 1 ATOM 2932 N N . VAL B 1 46 ? 56.380 92.627 -25.747 1.00 58.40 ? 40 VAL B N 1 ATOM 2933 C CA . VAL B 1 46 ? 55.472 92.250 -24.653 1.00 58.92 ? 40 VAL B CA 1 ATOM 2934 C C . VAL B 1 46 ? 54.622 91.039 -25.084 1.00 66.60 ? 40 VAL B C 1 ATOM 2935 O O . VAL B 1 46 ? 54.441 90.862 -26.290 1.00 68.01 ? 40 VAL B O 1 ATOM 2936 C CB . VAL B 1 46 ? 54.584 93.416 -24.143 1.00 62.53 ? 40 VAL B CB 1 ATOM 2937 C CG1 . VAL B 1 46 ? 55.406 94.451 -23.382 1.00 62.12 ? 40 VAL B CG1 1 ATOM 2938 C CG2 . VAL B 1 46 ? 53.748 94.052 -25.260 1.00 62.19 ? 40 VAL B CG2 1 ATOM 2939 N N . PRO B 1 47 ? 54.060 90.192 -24.184 1.00 63.38 ? 41 PRO B N 1 ATOM 2940 C CA . PRO B 1 47 ? 53.194 89.108 -24.683 1.00 63.13 ? 41 PRO B CA 1 ATOM 2941 C C . PRO B 1 47 ? 51.915 89.688 -25.324 1.00 69.45 ? 41 PRO B C 1 ATOM 2942 O O . PRO B 1 47 ? 51.438 90.762 -24.919 1.00 67.60 ? 41 PRO B O 1 ATOM 2943 C CB . PRO B 1 47 ? 52.924 88.247 -23.444 1.00 64.34 ? 41 PRO B CB 1 ATOM 2944 C CG . PRO B 1 47 ? 53.849 88.747 -22.374 1.00 68.69 ? 41 PRO B CG 1 ATOM 2945 C CD . PRO B 1 47 ? 54.140 90.178 -22.709 1.00 64.63 ? 41 PRO B CD 1 ATOM 2946 N N . SER B 1 48 ? 51.416 89.021 -26.385 1.00 68.79 ? 42 SER B N 1 ATOM 2947 C CA . SER B 1 48 ? 50.239 89.473 -27.136 1.00 69.64 ? 42 SER B CA 1 ATOM 2948 C C . SER B 1 48 ? 48.954 88.780 -26.723 1.00 74.74 ? 42 SER B C 1 ATOM 2949 O O . SER B 1 48 ? 48.993 87.644 -26.245 1.00 74.92 ? 42 SER B O 1 ATOM 2950 C CB . SER B 1 48 ? 50.460 89.264 -28.630 1.00 73.48 ? 42 SER B CB 1 ATOM 2951 O OG . SER B 1 48 ? 49.393 89.778 -29.408 1.00 79.38 ? 42 SER B OG 1 ATOM 2952 N N . SER B 1 49 ? 47.803 89.458 -26.948 1.00 71.80 ? 43 SER B N 1 ATOM 2953 C CA . SER B 1 49 ? 46.458 88.901 -26.733 1.00 71.93 ? 43 SER B CA 1 ATOM 2954 C C . SER B 1 49 ? 46.259 87.763 -27.772 1.00 77.37 ? 43 SER B C 1 ATOM 2955 O O . SER B 1 49 ? 45.558 86.784 -27.519 1.00 76.38 ? 43 SER B O 1 ATOM 2956 C CB . SER B 1 49 ? 45.397 89.981 -26.921 1.00 74.70 ? 43 SER B CB 1 ATOM 2957 O OG . SER B 1 49 ? 45.561 90.655 -28.158 1.00 85.68 ? 43 SER B OG 1 ATOM 2958 N N . LYS B 1 50 ? 46.954 87.878 -28.914 1.00 75.39 ? 44 LYS B N 1 ATOM 2959 C CA . LYS B 1 50 ? 46.939 86.903 -29.997 1.00 76.34 ? 44 LYS B CA 1 ATOM 2960 C C . LYS B 1 50 ? 47.815 85.671 -29.695 1.00 84.63 ? 44 LYS B C 1 ATOM 2961 O O . LYS B 1 50 ? 48.052 84.849 -30.580 1.00 83.17 ? 44 LYS B O 1 ATOM 2962 C CB . LYS B 1 50 ? 47.301 87.585 -31.325 1.00 77.51 ? 44 LYS B CB 1 ATOM 2963 C CG . LYS B 1 50 ? 46.230 88.589 -31.742 1.00 79.89 ? 44 LYS B CG 1 ATOM 2964 C CD . LYS B 1 50 ? 46.749 89.683 -32.654 1.00 89.98 ? 44 LYS B CD 1 ATOM 2965 C CE . LYS B 1 50 ? 45.697 90.737 -32.950 1.00 101.95 ? 44 LYS B CE 1 ATOM 2966 N NZ . LYS B 1 50 ? 45.485 91.683 -31.810 1.00 111.77 ? 44 LYS B NZ 1 ATOM 2967 N N . CYS B 1 51 ? 48.240 85.531 -28.424 1.00 85.93 ? 45 CYS B N 1 ATOM 2968 C CA . CYS B 1 51 ? 49.028 84.394 -27.990 1.00 88.33 ? 45 CYS B CA 1 ATOM 2969 C C . CYS B 1 51 ? 48.102 83.244 -27.597 1.00 96.94 ? 45 CYS B C 1 ATOM 2970 O O . CYS B 1 51 ? 47.140 83.452 -26.844 1.00 95.59 ? 45 CYS B O 1 ATOM 2971 C CB . CYS B 1 51 ? 49.990 84.758 -26.861 1.00 89.04 ? 45 CYS B CB 1 ATOM 2972 S SG . CYS B 1 51 ? 51.088 83.396 -26.375 1.00 93.43 ? 45 CYS B SG 1 ATOM 2973 N N . SER B 1 52 ? 48.396 82.029 -28.134 1.00 97.82 ? 46 SER B N 1 ATOM 2974 C CA . SER B 1 52 ? 47.661 80.783 -27.875 1.00 99.28 ? 46 SER B CA 1 ATOM 2975 C C . SER B 1 52 ? 47.781 80.384 -26.402 1.00 107.56 ? 46 SER B C 1 ATOM 2976 O O . SER B 1 52 ? 48.899 80.260 -25.888 1.00 108.03 ? 46 SER B O 1 ATOM 2977 C CB . SER B 1 52 ? 48.162 79.652 -28.772 1.00 101.99 ? 46 SER B CB 1 ATOM 2978 O OG . SER B 1 52 ? 49.480 79.883 -29.244 1.00 106.45 ? 46 SER B OG 1 ATOM 2979 N N . ARG B 1 53 ? 46.626 80.192 -25.724 1.00 106.06 ? 47 ARG B N 1 ATOM 2980 C CA . ARG B 1 53 ? 46.556 79.823 -24.301 1.00 106.75 ? 47 ARG B CA 1 ATOM 2981 C C . ARG B 1 53 ? 47.130 78.423 -24.002 1.00 112.70 ? 47 ARG B C 1 ATOM 2982 O O . ARG B 1 53 ? 47.115 77.972 -22.848 1.00 112.08 ? 47 ARG B O 1 ATOM 2983 C CB . ARG B 1 53 ? 45.128 79.988 -23.733 1.00 106.71 ? 47 ARG B CB 1 ATOM 2984 C CG . ARG B 1 53 ? 44.575 81.426 -23.734 1.00 117.87 ? 47 ARG B CG 1 ATOM 2985 C CD . ARG B 1 53 ? 45.546 82.514 -23.262 1.00 123.74 ? 47 ARG B CD 1 ATOM 2986 N NE . ARG B 1 53 ? 45.577 83.627 -24.218 1.00 126.22 ? 47 ARG B NE 1 ATOM 2987 C CZ . ARG B 1 53 ? 44.765 84.680 -24.173 1.00 135.19 ? 47 ARG B CZ 1 ATOM 2988 N NH1 . ARG B 1 53 ? 43.878 84.801 -23.192 1.00 122.13 ? 47 ARG B NH1 1 ATOM 2989 N NH2 . ARG B 1 53 ? 44.852 85.634 -25.093 1.00 115.58 ? 47 ARG B NH2 1 ATOM 2990 N N . LEU B 1 54 A 47.662 77.755 -25.053 1.00 110.35 ? 47 LEU B N 1 ATOM 2991 C CA . LEU B 1 54 A 48.358 76.474 -24.973 1.00 110.41 ? 47 LEU B CA 1 ATOM 2992 C C . LEU B 1 54 A 49.783 76.722 -24.429 1.00 113.72 ? 47 LEU B C 1 ATOM 2993 O O . LEU B 1 54 A 50.344 75.837 -23.770 1.00 113.02 ? 47 LEU B O 1 ATOM 2994 C CB . LEU B 1 54 A 48.363 75.758 -26.334 1.00 110.49 ? 47 LEU B CB 1 ATOM 2995 C CG . LEU B 1 54 A 47.076 75.012 -26.658 1.00 115.09 ? 47 LEU B CG 1 ATOM 2996 C CD1 . LEU B 1 54 A 46.837 74.971 -28.124 1.00 115.24 ? 47 LEU B CD1 1 ATOM 2997 C CD2 . LEU B 1 54 A 47.084 73.610 -26.069 1.00 117.43 ? 47 LEU B CD2 1 ATOM 2998 N N . TYR B 1 55 B 50.336 77.956 -24.667 1.00 110.07 ? 47 TYR B N 1 ATOM 2999 C CA . TYR B 1 55 B 51.599 78.438 -24.092 1.00 109.53 ? 47 TYR B CA 1 ATOM 3000 C C . TYR B 1 55 B 51.226 78.859 -22.686 1.00 109.90 ? 47 TYR B C 1 ATOM 3001 O O . TYR B 1 55 B 50.506 79.852 -22.509 1.00 109.03 ? 47 TYR B O 1 ATOM 3002 C CB . TYR B 1 55 B 52.166 79.663 -24.839 1.00 111.83 ? 47 TYR B CB 1 ATOM 3003 C CG . TYR B 1 55 B 52.744 79.320 -26.186 1.00 115.60 ? 47 TYR B CG 1 ATOM 3004 C CD1 . TYR B 1 55 B 53.992 78.711 -26.296 1.00 117.86 ? 47 TYR B CD1 1 ATOM 3005 C CD2 . TYR B 1 55 B 52.035 79.575 -27.354 1.00 117.05 ? 47 TYR B CD2 1 ATOM 3006 C CE1 . TYR B 1 55 B 54.521 78.370 -27.538 1.00 119.39 ? 47 TYR B CE1 1 ATOM 3007 C CE2 . TYR B 1 55 B 52.549 79.231 -28.601 1.00 118.39 ? 47 TYR B CE2 1 ATOM 3008 C CZ . TYR B 1 55 B 53.796 78.634 -28.688 1.00 127.65 ? 47 TYR B CZ 1 ATOM 3009 O OH . TYR B 1 55 B 54.308 78.291 -29.913 1.00 130.33 ? 47 TYR B OH 1 ATOM 3010 N N . THR B 1 56 ? 51.668 78.057 -21.696 1.00 104.50 ? 48 THR B N 1 ATOM 3011 C CA . THR B 1 56 ? 51.411 78.251 -20.260 1.00 103.61 ? 48 THR B CA 1 ATOM 3012 C C . THR B 1 56 ? 52.000 79.585 -19.779 1.00 104.73 ? 48 THR B C 1 ATOM 3013 O O . THR B 1 56 ? 51.534 80.137 -18.780 1.00 103.69 ? 48 THR B O 1 ATOM 3014 C CB . THR B 1 56 ? 51.886 77.025 -19.420 1.00 110.41 ? 48 THR B CB 1 ATOM 3015 O OG1 . THR B 1 56 ? 51.733 75.814 -20.166 1.00 110.87 ? 48 THR B OG1 1 ATOM 3016 C CG2 . THR B 1 56 ? 51.153 76.898 -18.078 1.00 105.61 ? 48 THR B CG2 1 ATOM 3017 N N . ALA B 1 57 ? 53.004 80.111 -20.519 1.00 99.19 ? 49 ALA B N 1 ATOM 3018 C CA . ALA B 1 57 ? 53.645 81.393 -20.236 1.00 97.55 ? 49 ALA B CA 1 ATOM 3019 C C . ALA B 1 57 ? 52.661 82.560 -20.460 1.00 96.75 ? 49 ALA B C 1 ATOM 3020 O O . ALA B 1 57 ? 52.552 83.441 -19.605 1.00 95.88 ? 49 ALA B O 1 ATOM 3021 C CB . ALA B 1 57 ? 54.883 81.555 -21.106 1.00 98.34 ? 49 ALA B CB 1 ATOM 3022 N N . CYS B 1 58 ? 51.905 82.521 -21.573 1.00 90.33 ? 50 CYS B N 1 ATOM 3023 C CA . CYS B 1 58 ? 50.916 83.526 -21.939 1.00 89.16 ? 50 CYS B CA 1 ATOM 3024 C C . CYS B 1 58 ? 49.712 83.561 -21.013 1.00 91.79 ? 50 CYS B C 1 ATOM 3025 O O . CYS B 1 58 ? 49.110 84.622 -20.835 1.00 92.03 ? 50 CYS B O 1 ATOM 3026 C CB . CYS B 1 58 ? 50.514 83.361 -23.393 1.00 89.40 ? 50 CYS B CB 1 ATOM 3027 S SG . CYS B 1 58 ? 51.819 83.840 -24.540 1.00 93.32 ? 50 CYS B SG 1 ATOM 3028 N N . VAL B 1 59 ? 49.400 82.431 -20.373 1.00 87.09 ? 51 VAL B N 1 ATOM 3029 C CA . VAL B 1 59 ? 48.317 82.357 -19.390 1.00 86.74 ? 51 VAL B CA 1 ATOM 3030 C C . VAL B 1 59 ? 48.777 83.047 -18.097 1.00 88.27 ? 51 VAL B C 1 ATOM 3031 O O . VAL B 1 59 ? 47.947 83.590 -17.363 1.00 88.37 ? 51 VAL B O 1 ATOM 3032 C CB . VAL B 1 59 ? 47.879 80.894 -19.111 1.00 90.83 ? 51 VAL B CB 1 ATOM 3033 C CG1 . VAL B 1 59 ? 46.623 80.843 -18.243 1.00 90.70 ? 51 VAL B CG1 1 ATOM 3034 C CG2 . VAL B 1 59 ? 47.648 80.134 -20.407 1.00 90.70 ? 51 VAL B CG2 1 ATOM 3035 N N . TYR B 1 60 ? 50.098 83.042 -17.834 1.00 82.69 ? 52 TYR B N 1 ATOM 3036 C CA . TYR B 1 60 ? 50.668 83.597 -16.612 1.00 81.94 ? 52 TYR B CA 1 ATOM 3037 C C . TYR B 1 60 ? 51.235 85.043 -16.733 1.00 78.58 ? 52 TYR B C 1 ATOM 3038 O O . TYR B 1 60 ? 51.699 85.572 -15.731 1.00 77.23 ? 52 TYR B O 1 ATOM 3039 C CB . TYR B 1 60 ? 51.705 82.613 -16.028 1.00 85.24 ? 52 TYR B CB 1 ATOM 3040 C CG . TYR B 1 60 ? 51.018 81.450 -15.334 1.00 90.26 ? 52 TYR B CG 1 ATOM 3041 C CD1 . TYR B 1 60 ? 50.583 81.557 -14.012 1.00 93.34 ? 52 TYR B CD1 1 ATOM 3042 C CD2 . TYR B 1 60 ? 50.697 80.286 -16.030 1.00 91.54 ? 52 TYR B CD2 1 ATOM 3043 C CE1 . TYR B 1 60 ? 49.878 80.517 -13.391 1.00 95.41 ? 52 TYR B CE1 1 ATOM 3044 C CE2 . TYR B 1 60 ? 49.997 79.240 -15.419 1.00 92.77 ? 52 TYR B CE2 1 ATOM 3045 C CZ . TYR B 1 60 ? 49.589 79.358 -14.099 1.00 100.97 ? 52 TYR B CZ 1 ATOM 3046 O OH . TYR B 1 60 ? 48.913 78.316 -13.501 1.00 99.70 ? 52 TYR B OH 1 ATOM 3047 N N . HIS B 1 61 ? 51.134 85.700 -17.905 1.00 70.93 ? 53 HIS B N 1 ATOM 3048 C CA . HIS B 1 61 ? 51.611 87.079 -18.077 1.00 68.83 ? 53 HIS B CA 1 ATOM 3049 C C . HIS B 1 61 ? 50.545 88.016 -18.636 1.00 68.06 ? 53 HIS B C 1 ATOM 3050 O O . HIS B 1 61 ? 49.550 87.549 -19.193 1.00 66.95 ? 53 HIS B O 1 ATOM 3051 C CB . HIS B 1 61 ? 52.879 87.126 -18.942 1.00 69.49 ? 53 HIS B CB 1 ATOM 3052 C CG . HIS B 1 61 ? 54.070 86.529 -18.264 1.00 72.92 ? 53 HIS B CG 1 ATOM 3053 N ND1 . HIS B 1 61 ? 54.441 85.220 -18.479 1.00 74.92 ? 53 HIS B ND1 1 ATOM 3054 C CD2 . HIS B 1 61 ? 54.905 87.073 -17.354 1.00 74.74 ? 53 HIS B CD2 1 ATOM 3055 C CE1 . HIS B 1 61 ? 55.503 85.012 -17.717 1.00 74.37 ? 53 HIS B CE1 1 ATOM 3056 N NE2 . HIS B 1 61 ? 55.827 86.101 -17.030 1.00 74.65 ? 53 HIS B NE2 1 ATOM 3057 N N . LYS B 1 62 ? 50.743 89.343 -18.454 1.00 61.50 ? 54 LYS B N 1 ATOM 3058 C CA . LYS B 1 62 ? 49.849 90.376 -18.990 1.00 59.98 ? 54 LYS B CA 1 ATOM 3059 C C . LYS B 1 62 ? 50.011 90.389 -20.518 1.00 63.51 ? 54 LYS B C 1 ATOM 3060 O O . LYS B 1 62 ? 51.134 90.325 -21.024 1.00 62.40 ? 54 LYS B O 1 ATOM 3061 C CB . LYS B 1 62 ? 50.162 91.770 -18.396 1.00 60.64 ? 54 LYS B CB 1 ATOM 3062 C CG . LYS B 1 62 ? 49.090 92.826 -18.666 1.00 52.33 ? 54 LYS B CG 1 ATOM 3063 C CD . LYS B 1 62 ? 48.546 93.388 -17.375 1.00 54.20 ? 54 LYS B CD 1 ATOM 3064 C CE . LYS B 1 62 ? 47.468 94.428 -17.582 1.00 63.66 ? 54 LYS B CE 1 ATOM 3065 N NZ . LYS B 1 62 ? 47.958 95.723 -18.141 1.00 70.46 ? 54 LYS B NZ 1 ATOM 3066 N N . LEU B 1 63 ? 48.889 90.455 -21.245 1.00 60.28 ? 55 LEU B N 1 ATOM 3067 C CA . LEU B 1 63 ? 48.928 90.465 -22.707 1.00 59.50 ? 55 LEU B CA 1 ATOM 3068 C C . LEU B 1 63 ? 48.426 91.759 -23.314 1.00 59.18 ? 55 LEU B C 1 ATOM 3069 O O . LEU B 1 63 ? 47.442 92.319 -22.850 1.00 57.87 ? 55 LEU B O 1 ATOM 3070 C CB . LEU B 1 63 ? 48.143 89.274 -23.260 1.00 59.90 ? 55 LEU B CB 1 ATOM 3071 C CG . LEU B 1 63 ? 48.320 87.928 -22.521 1.00 64.57 ? 55 LEU B CG 1 ATOM 3072 C CD1 . LEU B 1 63 ? 47.326 86.922 -23.003 1.00 65.03 ? 55 LEU B CD1 1 ATOM 3073 C CD2 . LEU B 1 63 ? 49.700 87.366 -22.686 1.00 65.04 ? 55 LEU B CD2 1 ATOM 3074 N N . PHE B 1 64 ? 49.125 92.246 -24.332 1.00 55.74 ? 56 PHE B N 1 ATOM 3075 C CA . PHE B 1 64 ? 48.725 93.460 -25.046 1.00 56.06 ? 56 PHE B CA 1 ATOM 3076 C C . PHE B 1 64 ? 47.603 93.145 -26.023 1.00 65.05 ? 56 PHE B C 1 ATOM 3077 O O . PHE B 1 64 ? 47.727 92.251 -26.881 1.00 64.29 ? 56 PHE B O 1 ATOM 3078 C CB . PHE B 1 64 ? 49.907 94.095 -25.799 1.00 56.96 ? 56 PHE B CB 1 ATOM 3079 C CG . PHE B 1 64 ? 49.531 95.339 -26.578 1.00 57.85 ? 56 PHE B CG 1 ATOM 3080 C CD1 . PHE B 1 64 ? 49.264 96.538 -25.923 1.00 59.87 ? 56 PHE B CD1 1 ATOM 3081 C CD2 . PHE B 1 64 ? 49.450 95.315 -27.965 1.00 58.75 ? 56 PHE B CD2 1 ATOM 3082 C CE1 . PHE B 1 64 ? 48.915 97.691 -26.647 1.00 60.03 ? 56 PHE B CE1 1 ATOM 3083 C CE2 . PHE B 1 64 ? 49.112 96.470 -28.684 1.00 60.83 ? 56 PHE B CE2 1 ATOM 3084 C CZ . PHE B 1 64 ? 48.856 97.651 -28.022 1.00 58.43 ? 56 PHE B CZ 1 ATOM 3085 N N . ASP B 1 65 ? 46.520 93.911 -25.892 1.00 65.21 ? 57 ASP B N 1 ATOM 3086 C CA . ASP B 1 65 ? 45.347 93.838 -26.750 1.00 66.19 ? 57 ASP B CA 1 ATOM 3087 C C . ASP B 1 65 ? 45.241 95.173 -27.518 1.00 70.22 ? 57 ASP B C 1 ATOM 3088 O O . ASP B 1 65 ? 44.906 96.220 -26.939 1.00 69.94 ? 57 ASP B O 1 ATOM 3089 C CB . ASP B 1 65 ? 44.082 93.536 -25.916 1.00 69.09 ? 57 ASP B CB 1 ATOM 3090 C CG . ASP B 1 65 ? 42.890 93.022 -26.708 1.00 85.43 ? 57 ASP B CG 1 ATOM 3091 O OD1 . ASP B 1 65 ? 42.837 93.265 -27.937 1.00 89.06 ? 57 ASP B OD1 1 ATOM 3092 O OD2 . ASP B 1 65 ? 42.001 92.395 -26.099 1.00 90.85 ? 57 ASP B OD2 1 ATOM 3093 N N . ALA B 1 66 ? 45.591 95.127 -28.822 1.00 66.68 ? 58 ALA B N 1 ATOM 3094 C CA . ALA B 1 66 ? 45.574 96.272 -29.754 1.00 65.98 ? 58 ALA B CA 1 ATOM 3095 C C . ALA B 1 66 ? 44.173 96.837 -30.003 1.00 69.45 ? 58 ALA B C 1 ATOM 3096 O O . ALA B 1 66 ? 44.042 98.022 -30.310 1.00 67.91 ? 58 ALA B O 1 ATOM 3097 C CB . ALA B 1 66 ? 46.224 95.880 -31.071 1.00 66.63 ? 58 ALA B CB 1 ATOM 3098 N N . SER B 1 67 ? 43.132 95.985 -29.864 1.00 67.93 ? 59 SER B N 1 ATOM 3099 C CA . SER B 1 67 ? 41.714 96.333 -30.025 1.00 68.65 ? 59 SER B CA 1 ATOM 3100 C C . SER B 1 67 ? 41.252 97.331 -28.954 1.00 73.86 ? 59 SER B C 1 ATOM 3101 O O . SER B 1 67 ? 40.195 97.948 -29.109 1.00 72.91 ? 59 SER B O 1 ATOM 3102 C CB . SER B 1 67 ? 40.858 95.073 -29.952 1.00 72.82 ? 59 SER B CB 1 ATOM 3103 O OG . SER B 1 67 ? 40.625 94.718 -28.601 1.00 85.49 ? 59 SER B OG 1 ATOM 3104 N N . ASP B 1 68 ? 42.028 97.458 -27.854 1.00 71.74 ? 60 ASP B N 1 ATOM 3105 C CA . ASP B 1 68 ? 41.708 98.370 -26.762 1.00 71.58 ? 60 ASP B CA 1 ATOM 3106 C C . ASP B 1 68 ? 42.499 99.672 -26.850 1.00 74.57 ? 60 ASP B C 1 ATOM 3107 O O . ASP B 1 68 ? 42.279 100.589 -26.048 1.00 74.23 ? 60 ASP B O 1 ATOM 3108 C CB . ASP B 1 68 ? 41.874 97.677 -25.403 1.00 73.61 ? 60 ASP B CB 1 ATOM 3109 C CG . ASP B 1 68 ? 40.878 96.556 -25.184 1.00 85.27 ? 60 ASP B CG 1 ATOM 3110 O OD1 . ASP B 1 68 ? 39.722 96.692 -25.640 1.00 88.03 ? 60 ASP B OD1 1 ATOM 3111 O OD2 . ASP B 1 68 ? 41.255 95.541 -24.563 1.00 88.46 ? 60 ASP B OD2 1 ATOM 3112 N N . SER B 1 69 ? 43.377 99.776 -27.852 1.00 70.09 ? 61 SER B N 1 ATOM 3113 C CA . SER B 1 69 ? 44.182 100.971 -28.008 1.00 70.17 ? 61 SER B CA 1 ATOM 3114 C C . SER B 1 69 ? 43.800 101.783 -29.231 1.00 76.14 ? 61 SER B C 1 ATOM 3115 O O . SER B 1 69 ? 43.751 101.251 -30.346 1.00 76.16 ? 61 SER B O 1 ATOM 3116 C CB . SER B 1 69 ? 45.666 100.626 -28.004 1.00 73.24 ? 61 SER B CB 1 ATOM 3117 O OG . SER B 1 69 ? 46.420 101.793 -28.288 1.00 80.28 ? 61 SER B OG 1 ATOM 3118 N N . SER B 1 70 ? 43.529 103.081 -29.012 1.00 72.81 ? 62 SER B N 1 ATOM 3119 C CA . SER B 1 70 ? 43.131 104.009 -30.072 1.00 72.59 ? 62 SER B CA 1 ATOM 3120 C C . SER B 1 70 ? 44.326 104.597 -30.821 1.00 75.90 ? 62 SER B C 1 ATOM 3121 O O . SER B 1 70 ? 44.137 105.262 -31.852 1.00 76.41 ? 62 SER B O 1 ATOM 3122 C CB . SER B 1 70 ? 42.259 105.123 -29.501 1.00 76.27 ? 62 SER B CB 1 ATOM 3123 O OG . SER B 1 70 ? 42.999 105.922 -28.595 1.00 86.43 ? 62 SER B OG 1 ATOM 3124 N N . SER B 1 71 ? 45.553 104.366 -30.301 1.00 70.09 ? 63 SER B N 1 ATOM 3125 C CA . SER B 1 71 ? 46.798 104.880 -30.884 1.00 68.44 ? 63 SER B CA 1 ATOM 3126 C C . SER B 1 71 ? 47.596 103.804 -31.627 1.00 68.62 ? 63 SER B C 1 ATOM 3127 O O . SER B 1 71 ? 48.617 104.107 -32.251 1.00 67.09 ? 63 SER B O 1 ATOM 3128 C CB . SER B 1 71 ? 47.639 105.596 -29.826 1.00 73.41 ? 63 SER B CB 1 ATOM 3129 O OG . SER B 1 71 ? 47.682 104.902 -28.587 1.00 86.96 ? 63 SER B OG 1 ATOM 3130 N N . TYR B 1 72 ? 47.088 102.566 -31.618 1.00 65.31 ? 64 TYR B N 1 ATOM 3131 C CA . TYR B 1 72 ? 47.716 101.432 -32.276 1.00 66.02 ? 64 TYR B CA 1 ATOM 3132 C C . TYR B 1 72 ? 47.715 101.574 -33.783 1.00 71.35 ? 64 TYR B C 1 ATOM 3133 O O . TYR B 1 72 ? 46.702 101.946 -34.375 1.00 70.05 ? 64 TYR B O 1 ATOM 3134 C CB . TYR B 1 72 ? 47.043 100.117 -31.844 1.00 68.46 ? 64 TYR B CB 1 ATOM 3135 C CG . TYR B 1 72 ? 47.306 98.933 -32.759 1.00 73.07 ? 64 TYR B CG 1 ATOM 3136 C CD1 . TYR B 1 72 ? 48.499 98.219 -32.686 1.00 75.85 ? 64 TYR B CD1 1 ATOM 3137 C CD2 . TYR B 1 72 ? 46.343 98.503 -33.675 1.00 74.20 ? 64 TYR B CD2 1 ATOM 3138 C CE1 . TYR B 1 72 ? 48.737 97.117 -33.513 1.00 78.43 ? 64 TYR B CE1 1 ATOM 3139 C CE2 . TYR B 1 72 ? 46.573 97.407 -34.508 1.00 75.19 ? 64 TYR B CE2 1 ATOM 3140 C CZ . TYR B 1 72 ? 47.767 96.711 -34.419 1.00 85.75 ? 64 TYR B CZ 1 ATOM 3141 O OH . TYR B 1 72 ? 47.981 95.626 -35.240 1.00 87.73 ? 64 TYR B OH 1 ATOM 3142 N N . LYS B 1 73 ? 48.862 101.274 -34.396 1.00 70.20 ? 65 LYS B N 1 ATOM 3143 C CA . LYS B 1 73 ? 49.058 101.265 -35.840 1.00 69.94 ? 65 LYS B CA 1 ATOM 3144 C C . LYS B 1 73 ? 49.611 99.917 -36.210 1.00 77.41 ? 65 LYS B C 1 ATOM 3145 O O . LYS B 1 73 ? 50.630 99.491 -35.670 1.00 77.11 ? 65 LYS B O 1 ATOM 3146 C CB . LYS B 1 73 ? 49.965 102.403 -36.322 1.00 70.79 ? 65 LYS B CB 1 ATOM 3147 C CG . LYS B 1 73 ? 49.164 103.689 -36.388 1.00 78.61 ? 65 LYS B CG 1 ATOM 3148 C CD . LYS B 1 73 ? 49.912 104.908 -36.035 1.00 88.14 ? 65 LYS B CD 1 ATOM 3149 C CE . LYS B 1 73 ? 49.024 106.148 -36.096 1.00 89.95 ? 65 LYS B CE 1 ATOM 3150 N NZ . LYS B 1 73 ? 47.837 106.045 -35.186 1.00 85.82 ? 65 LYS B NZ 1 ATOM 3151 N N . HIS B 1 74 ? 48.911 99.229 -37.108 1.00 76.95 ? 66 HIS B N 1 ATOM 3152 C CA . HIS B 1 74 ? 49.271 97.911 -37.608 1.00 77.60 ? 66 HIS B CA 1 ATOM 3153 C C . HIS B 1 74 ? 50.578 97.921 -38.422 1.00 78.01 ? 66 HIS B C 1 ATOM 3154 O O . HIS B 1 74 ? 50.901 98.916 -39.073 1.00 75.63 ? 66 HIS B O 1 ATOM 3155 C CB . HIS B 1 74 ? 48.117 97.382 -38.486 1.00 79.59 ? 66 HIS B CB 1 ATOM 3156 C CG . HIS B 1 74 ? 48.331 95.990 -39.008 1.00 84.09 ? 66 HIS B CG 1 ATOM 3157 N ND1 . HIS B 1 74 ? 47.927 94.878 -38.271 1.00 86.36 ? 66 HIS B ND1 1 ATOM 3158 C CD2 . HIS B 1 74 ? 48.904 95.562 -40.159 1.00 86.43 ? 66 HIS B CD2 1 ATOM 3159 C CE1 . HIS B 1 74 ? 48.276 93.821 -38.989 1.00 85.89 ? 66 HIS B CE1 1 ATOM 3160 N NE2 . HIS B 1 74 ? 48.876 94.178 -40.126 1.00 86.31 ? 66 HIS B NE2 1 ATOM 3161 N N . ASN B 1 75 ? 51.316 96.803 -38.367 1.00 74.80 ? 67 ASN B N 1 ATOM 3162 C CA . ASN B 1 75 ? 52.488 96.519 -39.190 1.00 75.44 ? 67 ASN B CA 1 ATOM 3163 C C . ASN B 1 75 ? 52.410 95.044 -39.611 1.00 80.34 ? 67 ASN B C 1 ATOM 3164 O O . ASN B 1 75 ? 52.212 94.760 -40.793 1.00 81.05 ? 67 ASN B O 1 ATOM 3165 C CB . ASN B 1 75 ? 53.827 96.896 -38.549 1.00 76.86 ? 67 ASN B CB 1 ATOM 3166 C CG . ASN B 1 75 ? 54.985 96.710 -39.509 1.00 94.81 ? 67 ASN B CG 1 ATOM 3167 O OD1 . ASN B 1 75 ? 55.434 95.581 -39.733 1.00 62.35 ? 67 ASN B OD1 1 ATOM 3168 N ND2 . ASN B 1 75 ? 55.481 97.808 -40.106 1.00 108.29 ? 67 ASN B ND2 1 ATOM 3169 N N . GLY B 1 76 ? 52.498 94.139 -38.644 1.00 75.70 ? 68 GLY B N 1 ATOM 3170 C CA . GLY B 1 76 ? 52.347 92.708 -38.873 1.00 75.01 ? 68 GLY B CA 1 ATOM 3171 C C . GLY B 1 76 ? 53.562 91.907 -39.296 1.00 78.15 ? 68 GLY B C 1 ATOM 3172 O O . GLY B 1 76 ? 53.469 90.672 -39.337 1.00 77.02 ? 68 GLY B O 1 ATOM 3173 N N . THR B 1 77 ? 54.707 92.581 -39.625 1.00 74.98 ? 69 THR B N 1 ATOM 3174 C CA . THR B 1 77 ? 55.961 91.908 -40.032 1.00 75.07 ? 69 THR B CA 1 ATOM 3175 C C . THR B 1 77 ? 56.371 90.901 -38.966 1.00 81.55 ? 69 THR B C 1 ATOM 3176 O O . THR B 1 77 ? 56.379 91.248 -37.784 1.00 81.80 ? 69 THR B O 1 ATOM 3177 C CB . THR B 1 77 ? 57.093 92.919 -40.265 1.00 78.95 ? 69 THR B CB 1 ATOM 3178 O OG1 . THR B 1 77 ? 56.705 93.808 -41.308 1.00 84.45 ? 69 THR B OG1 1 ATOM 3179 C CG2 . THR B 1 77 ? 58.416 92.258 -40.634 1.00 73.22 ? 69 THR B CG2 1 ATOM 3180 N N . GLU B 1 78 ? 56.672 89.654 -39.374 1.00 79.62 ? 70 GLU B N 1 ATOM 3181 C CA . GLU B 1 78 ? 57.083 88.600 -38.453 1.00 80.09 ? 70 GLU B CA 1 ATOM 3182 C C . GLU B 1 78 ? 58.399 88.998 -37.768 1.00 84.85 ? 70 GLU B C 1 ATOM 3183 O O . GLU B 1 78 ? 59.205 89.736 -38.345 1.00 84.94 ? 70 GLU B O 1 ATOM 3184 C CB . GLU B 1 78 ? 57.212 87.255 -39.179 1.00 81.58 ? 70 GLU B CB 1 ATOM 3185 C CG . GLU B 1 78 ? 57.118 86.036 -38.269 1.00 95.43 ? 70 GLU B CG 1 ATOM 3186 C CD . GLU B 1 78 ? 57.174 84.707 -39.002 1.00 126.91 ? 70 GLU B CD 1 ATOM 3187 O OE1 . GLU B 1 78 ? 58.254 84.360 -39.536 1.00 116.85 ? 70 GLU B OE1 1 ATOM 3188 O OE2 . GLU B 1 78 ? 56.130 84.016 -39.055 1.00 128.60 ? 70 GLU B OE2 1 ATOM 3189 N N . LEU B 1 79 ? 58.578 88.549 -36.516 1.00 79.98 ? 71 LEU B N 1 ATOM 3190 C CA . LEU B 1 79 ? 59.737 88.856 -35.688 1.00 78.18 ? 71 LEU B CA 1 ATOM 3191 C C . LEU B 1 79 ? 60.084 87.639 -34.855 1.00 77.93 ? 71 LEU B C 1 ATOM 3192 O O . LEU B 1 79 ? 59.194 87.044 -34.250 1.00 74.92 ? 71 LEU B O 1 ATOM 3193 C CB . LEU B 1 79 ? 59.374 90.045 -34.780 1.00 78.59 ? 71 LEU B CB 1 ATOM 3194 C CG . LEU B 1 79 ? 60.484 90.633 -33.902 1.00 83.89 ? 71 LEU B CG 1 ATOM 3195 C CD1 . LEU B 1 79 ? 61.183 91.812 -34.597 1.00 84.17 ? 71 LEU B CD1 1 ATOM 3196 C CD2 . LEU B 1 79 ? 59.918 91.041 -32.533 1.00 85.41 ? 71 LEU B CD2 1 ATOM 3197 N N . THR B 1 80 ? 61.375 87.251 -34.853 1.00 75.18 ? 72 THR B N 1 ATOM 3198 C CA . THR B 1 80 ? 61.900 86.140 -34.055 1.00 75.02 ? 72 THR B CA 1 ATOM 3199 C C . THR B 1 80 ? 63.120 86.629 -33.271 1.00 78.19 ? 72 THR B C 1 ATOM 3200 O O . THR B 1 80 ? 64.106 87.079 -33.862 1.00 77.89 ? 72 THR B O 1 ATOM 3201 C CB . THR B 1 80 ? 62.152 84.857 -34.884 1.00 80.70 ? 72 THR B CB 1 ATOM 3202 O OG1 . THR B 1 80 ? 60.927 84.442 -35.486 1.00 86.26 ? 72 THR B OG1 1 ATOM 3203 C CG2 . THR B 1 80 ? 62.663 83.704 -34.030 1.00 75.32 ? 72 THR B CG2 1 ATOM 3204 N N . LEU B 1 81 ? 63.024 86.563 -31.938 1.00 72.77 ? 73 LEU B N 1 ATOM 3205 C CA . LEU B 1 81 ? 64.084 86.965 -31.031 1.00 71.10 ? 73 LEU B CA 1 ATOM 3206 C C . LEU B 1 81 ? 64.592 85.726 -30.353 1.00 74.66 ? 73 LEU B C 1 ATOM 3207 O O . LEU B 1 81 ? 63.890 85.092 -29.570 1.00 72.94 ? 73 LEU B O 1 ATOM 3208 C CB . LEU B 1 81 ? 63.605 88.028 -30.032 1.00 70.46 ? 73 LEU B CB 1 ATOM 3209 C CG . LEU B 1 81 ? 62.802 89.179 -30.628 1.00 74.29 ? 73 LEU B CG 1 ATOM 3210 C CD1 . LEU B 1 81 ? 62.022 89.871 -29.580 1.00 74.10 ? 73 LEU B CD1 1 ATOM 3211 C CD2 . LEU B 1 81 ? 63.685 90.157 -31.353 1.00 75.78 ? 73 LEU B CD2 1 ATOM 3212 N N . ARG B 1 82 ? 65.797 85.333 -30.743 1.00 73.72 ? 74 ARG B N 1 ATOM 3213 C CA . ARG B 1 82 ? 66.488 84.146 -30.265 1.00 73.99 ? 74 ARG B CA 1 ATOM 3214 C C . ARG B 1 82 ? 67.492 84.596 -29.208 1.00 78.18 ? 74 ARG B C 1 ATOM 3215 O O . ARG B 1 82 ? 68.416 85.358 -29.515 1.00 79.06 ? 74 ARG B O 1 ATOM 3216 C CB . ARG B 1 82 ? 67.234 83.452 -31.434 1.00 75.66 ? 74 ARG B CB 1 ATOM 3217 C CG . ARG B 1 82 ? 66.416 83.229 -32.716 1.00 89.72 ? 74 ARG B CG 1 ATOM 3218 C CD . ARG B 1 82 ? 67.293 83.160 -33.957 1.00 98.45 ? 74 ARG B CD 1 ATOM 3219 N NE . ARG B 1 82 ? 66.497 83.017 -35.180 1.00 104.03 ? 74 ARG B NE 1 ATOM 3220 C CZ . ARG B 1 82 ? 67.002 82.915 -36.409 1.00 111.20 ? 74 ARG B CZ 1 ATOM 3221 N NH1 . ARG B 1 82 ? 68.318 82.938 -36.602 1.00 80.35 ? 74 ARG B NH1 1 ATOM 3222 N NH2 . ARG B 1 82 ? 66.194 82.784 -37.455 1.00 100.84 ? 74 ARG B NH2 1 ATOM 3223 N N . TYR B 1 83 ? 67.269 84.191 -27.958 1.00 72.45 ? 75 TYR B N 1 ATOM 3224 C CA . TYR B 1 83 ? 68.199 84.472 -26.876 1.00 71.16 ? 75 TYR B CA 1 ATOM 3225 C C . TYR B 1 83 ? 68.861 83.128 -26.600 1.00 77.51 ? 75 TYR B C 1 ATOM 3226 O O . TYR B 1 83 ? 68.263 82.089 -26.902 1.00 77.08 ? 75 TYR B O 1 ATOM 3227 C CB . TYR B 1 83 ? 67.473 84.973 -25.605 1.00 70.29 ? 75 TYR B CB 1 ATOM 3228 C CG . TYR B 1 83 ? 66.629 86.212 -25.795 1.00 68.76 ? 75 TYR B CG 1 ATOM 3229 C CD1 . TYR B 1 83 ? 67.218 87.457 -25.977 1.00 70.84 ? 75 TYR B CD1 1 ATOM 3230 C CD2 . TYR B 1 83 ? 65.243 86.152 -25.726 1.00 68.13 ? 75 TYR B CD2 1 ATOM 3231 C CE1 . TYR B 1 83 ? 66.447 88.607 -26.143 1.00 70.93 ? 75 TYR B CE1 1 ATOM 3232 C CE2 . TYR B 1 83 ? 64.460 87.295 -25.874 1.00 68.44 ? 75 TYR B CE2 1 ATOM 3233 C CZ . TYR B 1 83 ? 65.067 88.525 -26.082 1.00 73.14 ? 75 TYR B CZ 1 ATOM 3234 O OH . TYR B 1 83 ? 64.317 89.668 -26.241 1.00 69.27 ? 75 TYR B OH 1 ATOM 3235 N N . SER B 1 84 ? 70.069 83.135 -26.000 1.00 76.37 ? 76 SER B N 1 ATOM 3236 C CA . SER B 1 84 ? 70.778 81.901 -25.643 1.00 77.12 ? 76 SER B CA 1 ATOM 3237 C C . SER B 1 84 ? 70.014 81.146 -24.532 1.00 82.29 ? 76 SER B C 1 ATOM 3238 O O . SER B 1 84 ? 70.200 79.940 -24.373 1.00 81.49 ? 76 SER B O 1 ATOM 3239 C CB . SER B 1 84 ? 72.235 82.186 -25.259 1.00 80.86 ? 76 SER B CB 1 ATOM 3240 O OG . SER B 1 84 ? 72.888 82.860 -26.324 1.00 89.73 ? 76 SER B OG 1 ATOM 3241 N N . THR B 1 85 ? 69.099 81.853 -23.830 1.00 79.54 ? 77 THR B N 1 ATOM 3242 C CA . THR B 1 85 ? 68.245 81.344 -22.752 1.00 79.23 ? 77 THR B CA 1 ATOM 3243 C C . THR B 1 85 ? 66.965 80.689 -23.266 1.00 81.09 ? 77 THR B C 1 ATOM 3244 O O . THR B 1 85 ? 66.466 79.769 -22.620 1.00 81.12 ? 77 THR B O 1 ATOM 3245 C CB . THR B 1 85 ? 67.899 82.470 -21.760 1.00 89.75 ? 77 THR B CB 1 ATOM 3246 O OG1 . THR B 1 85 ? 68.136 83.755 -22.358 1.00 92.06 ? 77 THR B OG1 1 ATOM 3247 C CG2 . THR B 1 85 ? 68.648 82.334 -20.450 1.00 87.59 ? 77 THR B CG2 1 ATOM 3248 N N . GLY B 1 86 ? 66.438 81.194 -24.381 1.00 75.54 ? 78 GLY B N 1 ATOM 3249 C CA . GLY B 1 86 ? 65.201 80.743 -25.012 1.00 74.91 ? 78 GLY B CA 1 ATOM 3250 C C . GLY B 1 86 ? 64.810 81.636 -26.176 1.00 78.80 ? 78 GLY B C 1 ATOM 3251 O O . GLY B 1 86 ? 65.318 82.757 -26.281 1.00 79.40 ? 78 GLY B O 1 ATOM 3252 N N . THR B 1 87 ? 63.911 81.158 -27.074 1.00 73.31 ? 79 THR B N 1 ATOM 3253 C CA . THR B 1 87 ? 63.464 81.925 -28.248 1.00 71.88 ? 79 THR B CA 1 ATOM 3254 C C . THR B 1 87 ? 61.997 82.361 -28.131 1.00 72.98 ? 79 THR B C 1 ATOM 3255 O O . THR B 1 87 ? 61.185 81.663 -27.542 1.00 73.31 ? 79 THR B O 1 ATOM 3256 C CB . THR B 1 87 ? 63.776 81.143 -29.533 1.00 77.62 ? 79 THR B CB 1 ATOM 3257 O OG1 . THR B 1 87 ? 65.174 80.863 -29.537 1.00 80.20 ? 79 THR B OG1 1 ATOM 3258 C CG2 . THR B 1 87 ? 63.410 81.896 -30.811 1.00 72.28 ? 79 THR B CG2 1 ATOM 3259 N N . VAL B 1 88 ? 61.695 83.544 -28.666 1.00 66.50 ? 80 VAL B N 1 ATOM 3260 C CA . VAL B 1 88 ? 60.365 84.124 -28.711 1.00 65.48 ? 80 VAL B CA 1 ATOM 3261 C C . VAL B 1 88 ? 60.087 84.613 -30.120 1.00 68.39 ? 80 VAL B C 1 ATOM 3262 O O . VAL B 1 88 ? 61.015 84.960 -30.862 1.00 67.49 ? 80 VAL B O 1 ATOM 3263 C CB . VAL B 1 88 ? 60.100 85.240 -27.659 1.00 69.20 ? 80 VAL B CB 1 ATOM 3264 C CG1 . VAL B 1 88 ? 59.787 84.649 -26.297 1.00 69.09 ? 80 VAL B CG1 1 ATOM 3265 C CG2 . VAL B 1 88 ? 61.235 86.256 -27.581 1.00 68.85 ? 80 VAL B CG2 1 ATOM 3266 N N . SER B 1 89 ? 58.800 84.629 -30.492 1.00 63.55 ? 81 SER B N 1 ATOM 3267 C CA . SER B 1 89 ? 58.374 85.110 -31.798 1.00 62.32 ? 81 SER B CA 1 ATOM 3268 C C . SER B 1 89 ? 56.962 85.672 -31.769 1.00 63.21 ? 81 SER B C 1 ATOM 3269 O O . SER B 1 89 ? 56.135 85.333 -30.907 1.00 62.90 ? 81 SER B O 1 ATOM 3270 C CB . SER B 1 89 ? 58.553 84.051 -32.891 1.00 65.74 ? 81 SER B CB 1 ATOM 3271 O OG . SER B 1 89 ? 57.756 82.909 -32.642 1.00 70.51 ? 81 SER B OG 1 ATOM 3272 N N . GLY B 1 90 ? 56.723 86.566 -32.709 1.00 57.32 ? 82 GLY B N 1 ATOM 3273 C CA . GLY B 1 90 ? 55.458 87.248 -32.874 1.00 56.28 ? 82 GLY B CA 1 ATOM 3274 C C . GLY B 1 90 ? 55.548 88.144 -34.077 1.00 61.73 ? 82 GLY B C 1 ATOM 3275 O O . GLY B 1 90 ? 56.141 87.767 -35.096 1.00 62.72 ? 82 GLY B O 1 ATOM 3276 N N . PHE B 1 91 ? 54.997 89.344 -33.961 1.00 58.31 ? 83 PHE B N 1 ATOM 3277 C CA . PHE B 1 91 ? 54.955 90.271 -35.081 1.00 58.16 ? 83 PHE B CA 1 ATOM 3278 C C . PHE B 1 91 ? 55.063 91.716 -34.597 1.00 62.65 ? 83 PHE B C 1 ATOM 3279 O O . PHE B 1 91 ? 54.715 92.004 -33.449 1.00 60.87 ? 83 PHE B O 1 ATOM 3280 C CB . PHE B 1 91 ? 53.638 90.053 -35.886 1.00 59.33 ? 83 PHE B CB 1 ATOM 3281 C CG . PHE B 1 91 ? 52.381 90.308 -35.075 1.00 59.00 ? 83 PHE B CG 1 ATOM 3282 C CD1 . PHE B 1 91 ? 51.815 89.299 -34.301 1.00 60.88 ? 83 PHE B CD1 1 ATOM 3283 C CD2 . PHE B 1 91 ? 51.807 91.577 -35.031 1.00 59.70 ? 83 PHE B CD2 1 ATOM 3284 C CE1 . PHE B 1 91 ? 50.684 89.548 -33.511 1.00 61.79 ? 83 PHE B CE1 1 ATOM 3285 C CE2 . PHE B 1 91 ? 50.679 91.825 -34.243 1.00 62.15 ? 83 PHE B CE2 1 ATOM 3286 C CZ . PHE B 1 91 ? 50.115 90.807 -33.499 1.00 60.10 ? 83 PHE B CZ 1 ATOM 3287 N N . LEU B 1 92 ? 55.486 92.624 -35.498 1.00 60.22 ? 84 LEU B N 1 ATOM 3288 C CA . LEU B 1 92 ? 55.677 94.026 -35.192 1.00 60.77 ? 84 LEU B CA 1 ATOM 3289 C C . LEU B 1 92 ? 54.410 94.819 -35.209 1.00 66.52 ? 84 LEU B C 1 ATOM 3290 O O . LEU B 1 92 ? 53.594 94.666 -36.112 1.00 68.92 ? 84 LEU B O 1 ATOM 3291 C CB . LEU B 1 92 ? 56.698 94.661 -36.144 1.00 61.10 ? 84 LEU B CB 1 ATOM 3292 C CG . LEU B 1 92 ? 58.166 94.358 -35.879 1.00 65.81 ? 84 LEU B CG 1 ATOM 3293 C CD1 . LEU B 1 92 ? 58.983 94.631 -37.117 1.00 65.52 ? 84 LEU B CD1 1 ATOM 3294 C CD2 . LEU B 1 92 ? 58.703 95.156 -34.670 1.00 66.46 ? 84 LEU B CD2 1 ATOM 3295 N N . SER B 1 93 ? 54.270 95.706 -34.226 1.00 61.97 ? 85 SER B N 1 ATOM 3296 C CA . SER B 1 93 ? 53.154 96.638 -34.059 1.00 60.79 ? 85 SER B CA 1 ATOM 3297 C C . SER B 1 93 ? 53.717 97.989 -33.621 1.00 63.80 ? 85 SER B C 1 ATOM 3298 O O . SER B 1 93 ? 54.859 98.077 -33.145 1.00 64.09 ? 85 SER B O 1 ATOM 3299 C CB . SER B 1 93 ? 52.173 96.127 -33.008 1.00 63.38 ? 85 SER B CB 1 ATOM 3300 O OG . SER B 1 93 ? 51.835 94.766 -33.215 1.00 71.91 ? 85 SER B OG 1 ATOM 3301 N N . GLN B 1 94 ? 52.931 99.037 -33.792 1.00 58.20 ? 86 GLN B N 1 ATOM 3302 C CA . GLN B 1 94 ? 53.317 100.361 -33.354 1.00 57.45 ? 86 GLN B CA 1 ATOM 3303 C C . GLN B 1 94 ? 52.244 100.905 -32.442 1.00 62.99 ? 86 GLN B C 1 ATOM 3304 O O . GLN B 1 94 ? 51.053 100.710 -32.693 1.00 63.28 ? 86 GLN B O 1 ATOM 3305 C CB . GLN B 1 94 ? 53.523 101.311 -34.545 1.00 58.05 ? 86 GLN B CB 1 ATOM 3306 C CG . GLN B 1 94 ? 54.257 102.566 -34.171 1.00 63.31 ? 86 GLN B CG 1 ATOM 3307 C CD . GLN B 1 94 ? 54.074 103.631 -35.196 1.00 84.90 ? 86 GLN B CD 1 ATOM 3308 O OE1 . GLN B 1 94 ? 54.875 103.771 -36.111 1.00 84.80 ? 86 GLN B OE1 1 ATOM 3309 N NE2 . GLN B 1 94 ? 53.045 104.438 -35.030 1.00 72.99 ? 86 GLN B NE2 1 ATOM 3310 N N . ASP B 1 95 ? 52.681 101.589 -31.373 1.00 59.47 ? 87 ASP B N 1 ATOM 3311 C CA . ASP B 1 95 ? 51.832 102.287 -30.410 1.00 57.97 ? 87 ASP B CA 1 ATOM 3312 C C . ASP B 1 95 ? 52.678 103.296 -29.603 1.00 60.97 ? 87 ASP B C 1 ATOM 3313 O O . ASP B 1 95 ? 53.905 103.425 -29.825 1.00 58.95 ? 87 ASP B O 1 ATOM 3314 C CB . ASP B 1 95 ? 51.111 101.289 -29.484 1.00 58.66 ? 87 ASP B CB 1 ATOM 3315 C CG . ASP B 1 95 ? 49.716 101.723 -29.082 1.00 64.31 ? 87 ASP B CG 1 ATOM 3316 O OD1 . ASP B 1 95 ? 49.490 102.949 -28.925 1.00 61.94 ? 87 ASP B OD1 1 ATOM 3317 O OD2 . ASP B 1 95 ? 48.867 100.840 -28.852 1.00 72.68 ? 87 ASP B OD2 1 ATOM 3318 N N . ILE B 1 96 ? 52.006 104.033 -28.695 1.00 57.55 ? 88 ILE B N 1 ATOM 3319 C CA . ILE B 1 96 ? 52.668 104.972 -27.808 1.00 57.99 ? 88 ILE B CA 1 ATOM 3320 C C . ILE B 1 96 ? 53.031 104.231 -26.522 1.00 61.30 ? 88 ILE B C 1 ATOM 3321 O O . ILE B 1 96 ? 52.164 103.596 -25.900 1.00 60.09 ? 88 ILE B O 1 ATOM 3322 C CB . ILE B 1 96 ? 51.826 106.244 -27.554 1.00 62.06 ? 88 ILE B CB 1 ATOM 3323 C CG1 . ILE B 1 96 ? 51.593 107.024 -28.859 1.00 63.15 ? 88 ILE B CG1 1 ATOM 3324 C CG2 . ILE B 1 96 ? 52.457 107.144 -26.484 1.00 63.24 ? 88 ILE B CG2 1 ATOM 3325 C CD1 . ILE B 1 96 ? 50.312 107.831 -28.847 1.00 75.21 ? 88 ILE B CD1 1 ATOM 3326 N N . ILE B 1 97 ? 54.333 104.300 -26.149 1.00 57.14 ? 89 ILE B N 1 ATOM 3327 C CA . ILE B 1 97 ? 54.892 103.709 -24.938 1.00 55.77 ? 89 ILE B CA 1 ATOM 3328 C C . ILE B 1 97 ? 55.212 104.812 -23.929 1.00 59.27 ? 89 ILE B C 1 ATOM 3329 O O . ILE B 1 97 ? 55.851 105.819 -24.273 1.00 56.68 ? 89 ILE B O 1 ATOM 3330 C CB . ILE B 1 97 ? 56.080 102.741 -25.212 1.00 58.32 ? 89 ILE B CB 1 ATOM 3331 C CG1 . ILE B 1 97 ? 55.632 101.584 -26.160 1.00 58.21 ? 89 ILE B CG1 1 ATOM 3332 C CG2 . ILE B 1 97 ? 56.690 102.203 -23.874 1.00 59.18 ? 89 ILE B CG2 1 ATOM 3333 C CD1 . ILE B 1 97 ? 56.632 100.491 -26.430 1.00 57.17 ? 89 ILE B CD1 1 ATOM 3334 N N . THR B 1 98 ? 54.727 104.627 -22.686 1.00 57.86 ? 90 THR B N 1 ATOM 3335 C CA . THR B 1 98 ? 54.971 105.542 -21.578 1.00 57.94 ? 90 THR B CA 1 ATOM 3336 C C . THR B 1 98 ? 56.011 104.902 -20.683 1.00 60.38 ? 90 THR B C 1 ATOM 3337 O O . THR B 1 98 ? 55.794 103.811 -20.148 1.00 59.31 ? 90 THR B O 1 ATOM 3338 C CB . THR B 1 98 ? 53.671 105.943 -20.855 1.00 65.77 ? 90 THR B CB 1 ATOM 3339 O OG1 . THR B 1 98 ? 52.866 106.679 -21.762 1.00 72.50 ? 90 THR B OG1 1 ATOM 3340 C CG2 . THR B 1 98 ? 53.917 106.817 -19.644 1.00 62.27 ? 90 THR B CG2 1 ATOM 3341 N N . VAL B 1 99 ? 57.144 105.591 -20.538 1.00 56.97 ? 91 VAL B N 1 ATOM 3342 C CA . VAL B 1 99 ? 58.261 105.177 -19.695 1.00 56.95 ? 91 VAL B CA 1 ATOM 3343 C C . VAL B 1 99 ? 58.637 106.376 -18.792 1.00 60.91 ? 91 VAL B C 1 ATOM 3344 O O . VAL B 1 99 ? 59.077 107.427 -19.271 1.00 61.22 ? 91 VAL B O 1 ATOM 3345 C CB . VAL B 1 99 ? 59.410 104.520 -20.510 1.00 60.32 ? 91 VAL B CB 1 ATOM 3346 C CG1 . VAL B 1 99 ? 59.786 105.328 -21.744 1.00 59.90 ? 91 VAL B CG1 1 ATOM 3347 C CG2 . VAL B 1 99 ? 60.614 104.219 -19.643 1.00 60.09 ? 91 VAL B CG2 1 ATOM 3348 N N . GLY B 1 100 ? 58.291 106.233 -17.511 1.00 56.63 ? 92 GLY B N 1 ATOM 3349 C CA . GLY B 1 100 ? 58.430 107.261 -16.490 1.00 56.80 ? 92 GLY B CA 1 ATOM 3350 C C . GLY B 1 100 ? 57.518 108.427 -16.820 1.00 62.37 ? 92 GLY B C 1 ATOM 3351 O O . GLY B 1 100 ? 56.307 108.233 -16.995 1.00 63.38 ? 92 GLY B O 1 ATOM 3352 N N . GLY B 1 101 ? 58.086 109.602 -17.033 1.00 58.32 ? 93 GLY B N 1 ATOM 3353 C CA . GLY B 1 101 ? 57.293 110.764 -17.428 1.00 58.11 ? 93 GLY B CA 1 ATOM 3354 C C . GLY B 1 101 ? 57.401 111.060 -18.912 1.00 61.48 ? 93 GLY B C 1 ATOM 3355 O O . GLY B 1 101 ? 57.158 112.192 -19.339 1.00 60.85 ? 93 GLY B O 1 ATOM 3356 N N . ILE B 1 102 ? 57.812 110.052 -19.704 1.00 57.48 ? 94 ILE B N 1 ATOM 3357 C CA . ILE B 1 102 ? 58.060 110.207 -21.136 1.00 56.50 ? 94 ILE B CA 1 ATOM 3358 C C . ILE B 1 102 ? 57.125 109.344 -21.978 1.00 58.57 ? 94 ILE B C 1 ATOM 3359 O O . ILE B 1 102 ? 56.932 108.165 -21.699 1.00 57.64 ? 94 ILE B O 1 ATOM 3360 C CB . ILE B 1 102 ? 59.573 109.972 -21.433 1.00 58.90 ? 94 ILE B CB 1 ATOM 3361 C CG1 . ILE B 1 102 ? 60.385 111.169 -20.897 1.00 58.90 ? 94 ILE B CG1 1 ATOM 3362 C CG2 . ILE B 1 102 ? 59.851 109.727 -22.934 1.00 59.50 ? 94 ILE B CG2 1 ATOM 3363 C CD1 . ILE B 1 102 ? 61.855 111.081 -20.955 1.00 62.16 ? 94 ILE B CD1 1 ATOM 3364 N N . THR B 1 103 ? 56.590 109.951 -23.026 1.00 55.94 ? 95 THR B N 1 ATOM 3365 C CA . THR B 1 103 ? 55.678 109.349 -23.995 1.00 56.99 ? 95 THR B CA 1 ATOM 3366 C C . THR B 1 103 ? 56.400 109.295 -25.361 1.00 61.09 ? 95 THR B C 1 ATOM 3367 O O . THR B 1 103 ? 56.834 110.334 -25.879 1.00 60.91 ? 95 THR B O 1 ATOM 3368 C CB . THR B 1 103 ? 54.360 110.143 -23.927 1.00 66.75 ? 95 THR B CB 1 ATOM 3369 O OG1 . THR B 1 103 ? 53.483 109.487 -23.013 1.00 67.51 ? 95 THR B OG1 1 ATOM 3370 C CG2 . THR B 1 103 ? 53.691 110.329 -25.254 1.00 64.47 ? 95 THR B CG2 1 ATOM 3371 N N . VAL B 1 104 ? 56.587 108.087 -25.903 1.00 57.27 ? 96 VAL B N 1 ATOM 3372 C CA . VAL B 1 104 ? 57.293 107.889 -27.178 1.00 56.96 ? 96 VAL B CA 1 ATOM 3373 C C . VAL B 1 104 ? 56.499 106.993 -28.137 1.00 61.73 ? 96 VAL B C 1 ATOM 3374 O O . VAL B 1 104 ? 55.868 106.037 -27.687 1.00 60.72 ? 96 VAL B O 1 ATOM 3375 C CB . VAL B 1 104 ? 58.763 107.393 -26.966 1.00 60.00 ? 96 VAL B CB 1 ATOM 3376 C CG1 . VAL B 1 104 ? 58.828 105.955 -26.456 1.00 59.60 ? 96 VAL B CG1 1 ATOM 3377 C CG2 . VAL B 1 104 ? 59.635 107.582 -28.211 1.00 59.46 ? 96 VAL B CG2 1 ATOM 3378 N N . THR B 1 105 ? 56.526 107.312 -29.456 1.00 59.14 ? 97 THR B N 1 ATOM 3379 C CA . THR B 1 105 ? 55.885 106.478 -30.477 1.00 59.04 ? 97 THR B CA 1 ATOM 3380 C C . THR B 1 105 ? 56.906 105.378 -30.790 1.00 62.29 ? 97 THR B C 1 ATOM 3381 O O . THR B 1 105 ? 58.045 105.685 -31.136 1.00 61.64 ? 97 THR B O 1 ATOM 3382 C CB . THR B 1 105 ? 55.415 107.322 -31.664 1.00 67.53 ? 97 THR B CB 1 ATOM 3383 O OG1 . THR B 1 105 ? 54.478 108.300 -31.191 1.00 66.40 ? 97 THR B OG1 1 ATOM 3384 C CG2 . THR B 1 105 ? 54.783 106.477 -32.747 1.00 64.58 ? 97 THR B CG2 1 ATOM 3385 N N . GLN B 1 106 ? 56.525 104.101 -30.595 1.00 59.03 ? 99 GLN B N 1 ATOM 3386 C CA . GLN B 1 106 ? 57.472 103.000 -30.721 1.00 58.45 ? 99 GLN B CA 1 ATOM 3387 C C . GLN B 1 106 ? 56.908 101.771 -31.407 1.00 63.50 ? 99 GLN B C 1 ATOM 3388 O O . GLN B 1 106 ? 55.759 101.388 -31.175 1.00 62.99 ? 99 GLN B O 1 ATOM 3389 C CB . GLN B 1 106 ? 57.961 102.629 -29.293 1.00 59.35 ? 99 GLN B CB 1 ATOM 3390 C CG . GLN B 1 106 ? 59.027 101.540 -29.187 1.00 54.04 ? 99 GLN B CG 1 ATOM 3391 C CD . GLN B 1 106 ? 60.350 101.950 -29.787 1.00 62.82 ? 99 GLN B CD 1 ATOM 3392 O OE1 . GLN B 1 106 ? 60.740 103.123 -29.734 1.00 54.02 ? 99 GLN B OE1 1 ATOM 3393 N NE2 . GLN B 1 106 ? 61.061 100.987 -30.379 1.00 47.01 ? 99 GLN B NE2 1 ATOM 3394 N N . MET B 1 107 ? 57.769 101.136 -32.223 1.00 61.46 ? 100 MET B N 1 ATOM 3395 C CA . MET B 1 107 ? 57.551 99.872 -32.907 1.00 61.70 ? 100 MET B CA 1 ATOM 3396 C C . MET B 1 107 ? 58.065 98.780 -31.950 1.00 61.58 ? 100 MET B C 1 ATOM 3397 O O . MET B 1 107 ? 59.218 98.830 -31.468 1.00 60.19 ? 100 MET B O 1 ATOM 3398 C CB . MET B 1 107 ? 58.354 99.826 -34.218 1.00 65.19 ? 100 MET B CB 1 ATOM 3399 C CG . MET B 1 107 ? 57.708 100.539 -35.389 1.00 71.07 ? 100 MET B CG 1 ATOM 3400 S SD . MET B 1 107 ? 56.602 99.453 -36.327 1.00 77.40 ? 100 MET B SD 1 ATOM 3401 C CE . MET B 1 107 ? 57.808 98.226 -36.914 1.00 74.29 ? 100 MET B CE 1 ATOM 3402 N N . PHE B 1 108 ? 57.206 97.802 -31.661 1.00 54.59 ? 101 PHE B N 1 ATOM 3403 C CA . PHE B 1 108 ? 57.558 96.724 -30.739 1.00 52.16 ? 101 PHE B CA 1 ATOM 3404 C C . PHE B 1 108 ? 56.980 95.401 -31.245 1.00 61.14 ? 101 PHE B C 1 ATOM 3405 O O . PHE B 1 108 ? 56.106 95.401 -32.112 1.00 61.89 ? 101 PHE B O 1 ATOM 3406 C CB . PHE B 1 108 ? 57.045 97.066 -29.306 1.00 51.17 ? 101 PHE B CB 1 ATOM 3407 C CG . PHE B 1 108 ? 55.542 97.174 -29.188 1.00 49.18 ? 101 PHE B CG 1 ATOM 3408 C CD1 . PHE B 1 108 ? 54.879 98.336 -29.568 1.00 49.73 ? 101 PHE B CD1 1 ATOM 3409 C CD2 . PHE B 1 108 ? 54.781 96.088 -28.759 1.00 49.07 ? 101 PHE B CD2 1 ATOM 3410 C CE1 . PHE B 1 108 ? 53.480 98.414 -29.525 1.00 49.47 ? 101 PHE B CE1 1 ATOM 3411 C CE2 . PHE B 1 108 ? 53.381 96.168 -28.719 1.00 51.07 ? 101 PHE B CE2 1 ATOM 3412 C CZ . PHE B 1 108 ? 52.743 97.335 -29.098 1.00 47.87 ? 101 PHE B CZ 1 ATOM 3413 N N . GLY B 1 109 ? 57.440 94.297 -30.676 1.00 59.74 ? 102 GLY B N 1 ATOM 3414 C CA . GLY B 1 109 ? 56.945 92.979 -31.021 1.00 60.25 ? 102 GLY B CA 1 ATOM 3415 C C . GLY B 1 109 ? 55.820 92.546 -30.112 1.00 67.31 ? 102 GLY B C 1 ATOM 3416 O O . GLY B 1 109 ? 55.877 92.745 -28.893 1.00 67.51 ? 102 GLY B O 1 ATOM 3417 N N . GLU B 1 110 ? 54.776 91.972 -30.712 1.00 65.41 ? 103 GLU B N 1 ATOM 3418 C CA . GLU B 1 110 ? 53.642 91.382 -30.019 1.00 65.36 ? 103 GLU B CA 1 ATOM 3419 C C . GLU B 1 110 ? 53.944 89.893 -30.083 1.00 69.70 ? 103 GLU B C 1 ATOM 3420 O O . GLU B 1 110 ? 53.839 89.305 -31.150 1.00 69.88 ? 103 GLU B O 1 ATOM 3421 C CB . GLU B 1 110 ? 52.333 91.722 -30.732 1.00 66.78 ? 103 GLU B CB 1 ATOM 3422 C CG . GLU B 1 110 ? 51.502 92.738 -29.972 1.00 77.35 ? 103 GLU B CG 1 ATOM 3423 C CD . GLU B 1 110 ? 50.151 93.033 -30.591 1.00 83.75 ? 103 GLU B CD 1 ATOM 3424 O OE1 . GLU B 1 110 ? 50.069 94.003 -31.378 1.00 53.68 ? 103 GLU B OE1 1 ATOM 3425 O OE2 . GLU B 1 110 ? 49.183 92.291 -30.304 1.00 71.19 ? 103 GLU B OE2 1 ATOM 3426 N N . VAL B 1 111 ? 54.422 89.316 -28.968 1.00 66.12 ? 104 VAL B N 1 ATOM 3427 C CA . VAL B 1 111 ? 54.864 87.929 -28.880 1.00 65.49 ? 104 VAL B CA 1 ATOM 3428 C C . VAL B 1 111 ? 53.674 86.966 -28.790 1.00 71.77 ? 104 VAL B C 1 ATOM 3429 O O . VAL B 1 111 ? 52.811 87.109 -27.924 1.00 70.53 ? 104 VAL B O 1 ATOM 3430 C CB . VAL B 1 111 ? 55.922 87.754 -27.751 1.00 67.46 ? 104 VAL B CB 1 ATOM 3431 C CG1 . VAL B 1 111 ? 56.030 86.312 -27.267 1.00 66.88 ? 104 VAL B CG1 1 ATOM 3432 C CG2 . VAL B 1 111 ? 57.280 88.262 -28.217 1.00 66.75 ? 104 VAL B CG2 1 ATOM 3433 N N . THR B 1 112 ? 53.652 85.983 -29.713 1.00 71.15 ? 105 THR B N 1 ATOM 3434 C CA . THR B 1 112 ? 52.600 84.966 -29.829 1.00 71.73 ? 105 THR B CA 1 ATOM 3435 C C . THR B 1 112 ? 53.121 83.553 -29.503 1.00 77.75 ? 105 THR B C 1 ATOM 3436 O O . THR B 1 112 ? 52.320 82.638 -29.314 1.00 78.46 ? 105 THR B O 1 ATOM 3437 C CB . THR B 1 112 ? 51.901 85.058 -31.196 1.00 77.59 ? 105 THR B CB 1 ATOM 3438 O OG1 . THR B 1 112 ? 52.867 84.814 -32.221 1.00 81.03 ? 105 THR B OG1 1 ATOM 3439 C CG2 . THR B 1 112 ? 51.205 86.414 -31.424 1.00 74.08 ? 105 THR B CG2 1 ATOM 3440 N N . GLU B 1 113 ? 54.451 83.376 -29.427 1.00 75.06 ? 106 GLU B N 1 ATOM 3441 C CA . GLU B 1 113 ? 55.093 82.107 -29.070 1.00 75.64 ? 106 GLU B CA 1 ATOM 3442 C C . GLU B 1 113 ? 56.076 82.402 -27.949 1.00 81.12 ? 106 GLU B C 1 ATOM 3443 O O . GLU B 1 113 ? 57.094 83.073 -28.153 1.00 81.15 ? 106 GLU B O 1 ATOM 3444 C CB . GLU B 1 113 ? 55.765 81.430 -30.278 1.00 77.33 ? 106 GLU B CB 1 ATOM 3445 C CG . GLU B 1 113 ? 54.778 80.995 -31.351 1.00 95.90 ? 106 GLU B CG 1 ATOM 3446 C CD . GLU B 1 113 ? 55.401 80.654 -32.690 1.00 130.50 ? 106 GLU B CD 1 ATOM 3447 O OE1 . GLU B 1 113 ? 55.881 79.507 -32.857 1.00 126.53 ? 106 GLU B OE1 1 ATOM 3448 O OE2 . GLU B 1 113 ? 55.402 81.537 -33.578 1.00 131.13 ? 106 GLU B OE2 1 ATOM 3449 N N . MET B 1 114 ? 55.712 81.928 -26.742 1.00 78.23 ? 107 MET B N 1 ATOM 3450 C CA . MET B 1 114 ? 56.403 82.125 -25.474 1.00 77.68 ? 107 MET B CA 1 ATOM 3451 C C . MET B 1 114 ? 56.638 80.781 -24.745 1.00 82.00 ? 107 MET B C 1 ATOM 3452 O O . MET B 1 114 ? 55.733 80.284 -24.065 1.00 83.24 ? 107 MET B O 1 ATOM 3453 C CB . MET B 1 114 ? 55.565 83.081 -24.603 1.00 79.68 ? 107 MET B CB 1 ATOM 3454 C CG . MET B 1 114 ? 56.381 83.878 -23.632 1.00 82.96 ? 107 MET B CG 1 ATOM 3455 S SD . MET B 1 114 ? 55.568 85.426 -23.211 1.00 86.41 ? 107 MET B SD 1 ATOM 3456 C CE . MET B 1 114 ? 55.739 85.380 -21.457 1.00 83.21 ? 107 MET B CE 1 ATOM 3457 N N . PRO B 1 115 ? 57.846 80.186 -24.852 1.00 77.19 ? 108 PRO B N 1 ATOM 3458 C CA . PRO B 1 115 ? 58.087 78.889 -24.181 1.00 76.94 ? 108 PRO B CA 1 ATOM 3459 C C . PRO B 1 115 ? 58.202 78.933 -22.655 1.00 82.34 ? 108 PRO B C 1 ATOM 3460 O O . PRO B 1 115 ? 58.838 79.842 -22.118 1.00 82.60 ? 108 PRO B O 1 ATOM 3461 C CB . PRO B 1 115 ? 59.390 78.396 -24.811 1.00 78.40 ? 108 PRO B CB 1 ATOM 3462 C CG . PRO B 1 115 ? 60.065 79.610 -25.266 1.00 82.91 ? 108 PRO B CG 1 ATOM 3463 C CD . PRO B 1 115 ? 59.013 80.613 -25.644 1.00 78.52 ? 108 PRO B CD 1 ATOM 3464 N N . ALA B 1 116 ? 57.638 77.918 -21.955 1.00 78.73 ? 109 ALA B N 1 ATOM 3465 C CA . ALA B 1 116 ? 57.705 77.782 -20.490 1.00 78.75 ? 109 ALA B CA 1 ATOM 3466 C C . ALA B 1 116 ? 59.140 77.903 -19.988 1.00 84.05 ? 109 ALA B C 1 ATOM 3467 O O . ALA B 1 116 ? 59.381 78.462 -18.913 1.00 84.23 ? 109 ALA B O 1 ATOM 3468 C CB . ALA B 1 116 ? 57.112 76.454 -20.048 1.00 79.43 ? 109 ALA B CB 1 ATOM 3469 N N . LEU B 1 117 ? 60.095 77.407 -20.777 1.00 80.69 ? 110 LEU B N 1 ATOM 3470 C CA . LEU B 1 117 ? 61.488 77.565 -20.446 1.00 80.67 ? 110 LEU B CA 1 ATOM 3471 C C . LEU B 1 117 ? 62.071 78.681 -21.307 1.00 84.10 ? 110 LEU B C 1 ATOM 3472 O O . LEU B 1 117 ? 62.139 78.534 -22.538 1.00 83.73 ? 110 LEU B O 1 ATOM 3473 C CB . LEU B 1 117 ? 62.271 76.265 -20.630 1.00 80.74 ? 110 LEU B CB 1 ATOM 3474 C CG . LEU B 1 117 ? 62.361 75.397 -19.395 1.00 85.52 ? 110 LEU B CG 1 ATOM 3475 C CD1 . LEU B 1 117 ? 62.419 73.916 -19.765 1.00 85.38 ? 110 LEU B CD1 1 ATOM 3476 C CD2 . LEU B 1 117 ? 63.511 75.855 -18.449 1.00 87.50 ? 110 LEU B CD2 1 ATOM 3477 N N . PRO B 1 118 ? 62.416 79.839 -20.690 1.00 79.04 ? 111 PRO B N 1 ATOM 3478 C CA . PRO B 1 118 ? 62.383 80.162 -19.253 1.00 77.64 ? 111 PRO B CA 1 ATOM 3479 C C . PRO B 1 118 ? 61.256 81.135 -18.801 1.00 76.37 ? 111 PRO B C 1 ATOM 3480 O O . PRO B 1 118 ? 61.291 81.618 -17.666 1.00 75.36 ? 111 PRO B O 1 ATOM 3481 C CB . PRO B 1 118 ? 63.762 80.818 -19.064 1.00 79.77 ? 111 PRO B CB 1 ATOM 3482 C CG . PRO B 1 118 ? 64.078 81.482 -20.442 1.00 84.44 ? 111 PRO B CG 1 ATOM 3483 C CD . PRO B 1 118 ? 63.064 80.937 -21.435 1.00 80.28 ? 111 PRO B CD 1 ATOM 3484 N N . PHE B 1 119 ? 60.262 81.420 -19.666 1.00 68.88 ? 112 PHE B N 1 ATOM 3485 C CA . PHE B 1 119 ? 59.233 82.427 -19.413 1.00 67.16 ? 112 PHE B CA 1 ATOM 3486 C C . PHE B 1 119 ? 58.171 82.055 -18.366 1.00 73.71 ? 112 PHE B C 1 ATOM 3487 O O . PHE B 1 119 ? 57.406 82.938 -17.964 1.00 74.29 ? 112 PHE B O 1 ATOM 3488 C CB . PHE B 1 119 ? 58.588 82.892 -20.722 1.00 67.99 ? 112 PHE B CB 1 ATOM 3489 C CG . PHE B 1 119 ? 59.602 83.564 -21.621 1.00 68.63 ? 112 PHE B CG 1 ATOM 3490 C CD1 . PHE B 1 119 ? 60.008 84.870 -21.383 1.00 71.49 ? 112 PHE B CD1 1 ATOM 3491 C CD2 . PHE B 1 119 ? 60.217 82.860 -22.650 1.00 70.67 ? 112 PHE B CD2 1 ATOM 3492 C CE1 . PHE B 1 119 ? 60.990 85.469 -22.174 1.00 72.38 ? 112 PHE B CE1 1 ATOM 3493 C CE2 . PHE B 1 119 ? 61.223 83.448 -23.420 1.00 73.22 ? 112 PHE B CE2 1 ATOM 3494 C CZ . PHE B 1 119 ? 61.592 84.754 -23.188 1.00 71.37 ? 112 PHE B CZ 1 ATOM 3495 N N . MET B 1 120 ? 58.151 80.815 -17.866 1.00 70.85 ? 113 MET B N 1 ATOM 3496 C CA . MET B 1 120 ? 57.237 80.465 -16.778 1.00 71.75 ? 113 MET B CA 1 ATOM 3497 C C . MET B 1 120 ? 57.892 80.886 -15.467 1.00 72.64 ? 113 MET B C 1 ATOM 3498 O O . MET B 1 120 ? 57.202 81.040 -14.456 1.00 72.58 ? 113 MET B O 1 ATOM 3499 C CB . MET B 1 120 ? 56.926 78.952 -16.745 1.00 75.52 ? 113 MET B CB 1 ATOM 3500 C CG . MET B 1 120 ? 55.617 78.574 -17.377 1.00 81.13 ? 113 MET B CG 1 ATOM 3501 S SD . MET B 1 120 ? 54.176 79.433 -16.701 1.00 87.48 ? 113 MET B SD 1 ATOM 3502 C CE . MET B 1 120 ? 53.907 78.481 -15.214 1.00 84.64 ? 113 MET B CE 1 ATOM 3503 N N . LEU B 1 121 ? 59.236 81.066 -15.497 1.00 66.44 ? 114 LEU B N 1 ATOM 3504 C CA . LEU B 1 121 ? 60.077 81.470 -14.372 1.00 64.46 ? 114 LEU B CA 1 ATOM 3505 C C . LEU B 1 121 ? 60.157 82.996 -14.293 1.00 61.10 ? 114 LEU B C 1 ATOM 3506 O O . LEU B 1 121 ? 60.571 83.529 -13.258 1.00 61.18 ? 114 LEU B O 1 ATOM 3507 C CB . LEU B 1 121 ? 61.506 80.908 -14.523 1.00 65.03 ? 114 LEU B CB 1 ATOM 3508 C CG . LEU B 1 121 ? 61.708 79.475 -14.986 1.00 70.80 ? 114 LEU B CG 1 ATOM 3509 C CD1 . LEU B 1 121 ? 63.084 79.300 -15.603 1.00 71.47 ? 114 LEU B CD1 1 ATOM 3510 C CD2 . LEU B 1 121 ? 61.569 78.535 -13.846 1.00 73.94 ? 114 LEU B CD2 1 ATOM 3511 N N . ALA B 1 122 ? 59.791 83.679 -15.390 1.00 52.01 ? 115 ALA B N 1 ATOM 3512 C CA . ALA B 1 122 ? 59.816 85.122 -15.507 1.00 50.63 ? 115 ALA B CA 1 ATOM 3513 C C . ALA B 1 122 ? 58.725 85.818 -14.696 1.00 54.52 ? 115 ALA B C 1 ATOM 3514 O O . ALA B 1 122 ? 57.549 85.468 -14.801 1.00 56.33 ? 115 ALA B O 1 ATOM 3515 C CB . ALA B 1 122 ? 59.719 85.529 -16.969 1.00 50.65 ? 115 ALA B CB 1 ATOM 3516 N N . GLU B 1 123 ? 59.119 86.837 -13.927 1.00 48.33 ? 116 GLU B N 1 ATOM 3517 C CA . GLU B 1 123 ? 58.229 87.665 -13.107 1.00 47.06 ? 116 GLU B CA 1 ATOM 3518 C C . GLU B 1 123 ? 57.807 88.895 -13.888 1.00 49.16 ? 116 GLU B C 1 ATOM 3519 O O . GLU B 1 123 ? 56.791 89.531 -13.596 1.00 49.07 ? 116 GLU B O 1 ATOM 3520 C CB . GLU B 1 123 ? 58.908 88.036 -11.770 1.00 48.28 ? 116 GLU B CB 1 ATOM 3521 C CG . GLU B 1 123 ? 59.022 86.860 -10.807 1.00 53.54 ? 116 GLU B CG 1 ATOM 3522 C CD . GLU B 1 123 ? 57.705 86.239 -10.367 1.00 65.00 ? 116 GLU B CD 1 ATOM 3523 O OE1 . GLU B 1 123 ? 57.709 85.041 -10.002 1.00 53.71 ? 116 GLU B OE1 1 ATOM 3524 O OE2 . GLU B 1 123 ? 56.666 86.938 -10.407 1.00 55.99 ? 116 GLU B OE2 1 ATOM 3525 N N . PHE B 1 124 ? 58.591 89.202 -14.902 1.00 45.06 ? 117 PHE B N 1 ATOM 3526 C CA . PHE B 1 124 ? 58.356 90.269 -15.856 1.00 45.35 ? 117 PHE B CA 1 ATOM 3527 C C . PHE B 1 124 ? 57.561 89.679 -17.002 1.00 50.45 ? 117 PHE B C 1 ATOM 3528 O O . PHE B 1 124 ? 57.647 88.464 -17.241 1.00 49.80 ? 117 PHE B O 1 ATOM 3529 C CB . PHE B 1 124 ? 59.703 90.808 -16.396 1.00 47.38 ? 117 PHE B CB 1 ATOM 3530 C CG . PHE B 1 124 ? 60.657 89.772 -16.960 1.00 48.74 ? 117 PHE B CG 1 ATOM 3531 C CD1 . PHE B 1 124 ? 61.493 89.026 -16.112 1.00 51.64 ? 117 PHE B CD1 1 ATOM 3532 C CD2 . PHE B 1 124 ? 60.756 89.568 -18.337 1.00 49.36 ? 117 PHE B CD2 1 ATOM 3533 C CE1 . PHE B 1 124 ? 62.401 88.096 -16.637 1.00 52.12 ? 117 PHE B CE1 1 ATOM 3534 C CE2 . PHE B 1 124 ? 61.661 88.633 -18.854 1.00 51.84 ? 117 PHE B CE2 1 ATOM 3535 C CZ . PHE B 1 124 ? 62.487 87.917 -17.999 1.00 50.09 ? 117 PHE B CZ 1 ATOM 3536 N N . ASP B 1 125 ? 56.837 90.539 -17.750 1.00 47.69 ? 118 ASP B N 1 ATOM 3537 C CA . ASP B 1 125 ? 56.037 90.143 -18.916 1.00 48.17 ? 118 ASP B CA 1 ATOM 3538 C C . ASP B 1 125 ? 56.854 90.195 -20.188 1.00 52.04 ? 118 ASP B C 1 ATOM 3539 O O . ASP B 1 125 ? 56.818 89.254 -20.971 1.00 53.06 ? 118 ASP B O 1 ATOM 3540 C CB . ASP B 1 125 ? 54.775 91.026 -19.072 1.00 50.68 ? 118 ASP B CB 1 ATOM 3541 C CG . ASP B 1 125 ? 53.915 91.128 -17.832 1.00 55.26 ? 118 ASP B CG 1 ATOM 3542 O OD1 . ASP B 1 125 ? 53.471 90.068 -17.332 1.00 59.26 ? 118 ASP B OD1 1 ATOM 3543 O OD2 . ASP B 1 125 ? 53.686 92.271 -17.360 1.00 46.03 ? 118 ASP B OD2 1 ATOM 3544 N N . GLY B 1 126 ? 57.557 91.299 -20.392 1.00 47.68 ? 119 GLY B N 1 ATOM 3545 C CA . GLY B 1 126 ? 58.362 91.534 -21.583 1.00 46.49 ? 119 GLY B CA 1 ATOM 3546 C C . GLY B 1 126 ? 59.736 92.145 -21.370 1.00 49.93 ? 119 GLY B C 1 ATOM 3547 O O . GLY B 1 126 ? 60.304 92.085 -20.274 1.00 50.36 ? 119 GLY B O 1 ATOM 3548 N N . VAL B 1 127 ? 60.301 92.697 -22.453 1.00 44.35 ? 120 VAL B N 1 ATOM 3549 C CA . VAL B 1 127 ? 61.652 93.243 -22.500 1.00 43.19 ? 120 VAL B CA 1 ATOM 3550 C C . VAL B 1 127 ? 61.692 94.583 -23.228 1.00 48.32 ? 120 VAL B C 1 ATOM 3551 O O . VAL B 1 127 ? 61.051 94.746 -24.252 1.00 49.13 ? 120 VAL B O 1 ATOM 3552 C CB . VAL B 1 127 ? 62.631 92.218 -23.164 1.00 46.17 ? 120 VAL B CB 1 ATOM 3553 C CG1 . VAL B 1 127 ? 64.072 92.746 -23.223 1.00 45.78 ? 120 VAL B CG1 1 ATOM 3554 C CG2 . VAL B 1 127 ? 62.589 90.856 -22.463 1.00 45.89 ? 120 VAL B CG2 1 ATOM 3555 N N . VAL B 1 128 ? 62.481 95.524 -22.717 1.00 45.37 ? 121 VAL B N 1 ATOM 3556 C CA . VAL B 1 128 ? 62.758 96.814 -23.342 1.00 44.40 ? 121 VAL B CA 1 ATOM 3557 C C . VAL B 1 128 ? 64.274 96.801 -23.586 1.00 50.36 ? 121 VAL B C 1 ATOM 3558 O O . VAL B 1 128 ? 65.064 96.870 -22.630 1.00 51.47 ? 121 VAL B O 1 ATOM 3559 C CB . VAL B 1 128 ? 62.281 98.021 -22.501 1.00 46.78 ? 121 VAL B CB 1 ATOM 3560 C CG1 . VAL B 1 128 ? 62.938 99.321 -22.964 1.00 46.32 ? 121 VAL B CG1 1 ATOM 3561 C CG2 . VAL B 1 128 ? 60.766 98.157 -22.556 1.00 45.95 ? 121 VAL B CG2 1 ATOM 3562 N N . GLY B 1 129 ? 64.655 96.633 -24.848 1.00 45.63 ? 122 GLY B N 1 ATOM 3563 C CA . GLY B 1 129 ? 66.049 96.578 -25.261 1.00 44.77 ? 122 GLY B CA 1 ATOM 3564 C C . GLY B 1 129 ? 66.687 97.945 -25.209 1.00 47.94 ? 122 GLY B C 1 ATOM 3565 O O . GLY B 1 129 ? 66.146 98.911 -25.777 1.00 47.45 ? 122 GLY B O 1 ATOM 3566 N N . MET B 1 130 ? 67.815 98.043 -24.465 1.00 42.28 ? 123 MET B N 1 ATOM 3567 C CA . MET B 1 130 ? 68.543 99.304 -24.256 1.00 39.87 ? 123 MET B CA 1 ATOM 3568 C C . MET B 1 130 ? 69.829 99.328 -25.077 1.00 44.97 ? 123 MET B C 1 ATOM 3569 O O . MET B 1 130 ? 70.648 100.245 -24.957 1.00 43.20 ? 123 MET B O 1 ATOM 3570 C CB . MET B 1 130 ? 68.807 99.559 -22.744 1.00 40.76 ? 123 MET B CB 1 ATOM 3571 C CG . MET B 1 130 ? 67.550 99.700 -21.891 1.00 42.59 ? 123 MET B CG 1 ATOM 3572 S SD . MET B 1 130 ? 66.389 101.015 -22.391 1.00 46.16 ? 123 MET B SD 1 ATOM 3573 C CE . MET B 1 130 ? 67.292 102.487 -21.930 1.00 42.73 ? 123 MET B CE 1 ATOM 3574 N N . GLY B 1 131 ? 69.998 98.299 -25.906 1.00 44.80 ? 124 GLY B N 1 ATOM 3575 C CA . GLY B 1 131 ? 71.125 98.163 -26.823 1.00 45.02 ? 124 GLY B CA 1 ATOM 3576 C C . GLY B 1 131 ? 71.019 99.078 -28.033 1.00 51.90 ? 124 GLY B C 1 ATOM 3577 O O . GLY B 1 131 ? 70.156 99.973 -28.097 1.00 49.85 ? 124 GLY B O 1 ATOM 3578 N N . PHE B 1 132 ? 71.928 98.873 -29.000 1.00 53.40 ? 125 PHE B N 1 ATOM 3579 C CA . PHE B 1 132 ? 72.022 99.705 -30.207 1.00 55.05 ? 125 PHE B CA 1 ATOM 3580 C C . PHE B 1 132 ? 71.265 99.114 -31.392 1.00 61.53 ? 125 PHE B C 1 ATOM 3581 O O . PHE B 1 132 ? 71.101 97.893 -31.452 1.00 60.93 ? 125 PHE B O 1 ATOM 3582 C CB . PHE B 1 132 ? 73.485 99.909 -30.601 1.00 56.90 ? 125 PHE B CB 1 ATOM 3583 C CG . PHE B 1 132 ? 74.392 100.582 -29.600 1.00 58.99 ? 125 PHE B CG 1 ATOM 3584 C CD1 . PHE B 1 132 ? 74.868 99.889 -28.494 1.00 61.67 ? 125 PHE B CD1 1 ATOM 3585 C CD2 . PHE B 1 132 ? 74.864 101.874 -29.823 1.00 61.74 ? 125 PHE B CD2 1 ATOM 3586 C CE1 . PHE B 1 132 ? 75.757 100.490 -27.607 1.00 62.53 ? 125 PHE B CE1 1 ATOM 3587 C CE2 . PHE B 1 132 ? 75.746 102.477 -28.928 1.00 64.00 ? 125 PHE B CE2 1 ATOM 3588 C CZ . PHE B 1 132 ? 76.171 101.788 -27.817 1.00 61.85 ? 125 PHE B CZ 1 ATOM 3589 N N . ILE B 1 133 ? 70.873 99.976 -32.373 1.00 58.96 ? 126 ILE B N 1 ATOM 3590 C CA . ILE B 1 133 ? 70.157 99.590 -33.598 1.00 58.81 ? 126 ILE B CA 1 ATOM 3591 C C . ILE B 1 133 ? 70.869 98.443 -34.339 1.00 62.16 ? 126 ILE B C 1 ATOM 3592 O O . ILE B 1 133 ? 70.186 97.551 -34.831 1.00 63.74 ? 126 ILE B O 1 ATOM 3593 C CB . ILE B 1 133 ? 69.842 100.810 -34.504 1.00 62.07 ? 126 ILE B CB 1 ATOM 3594 C CG1 . ILE B 1 133 ? 68.770 100.468 -35.552 1.00 61.54 ? 126 ILE B CG1 1 ATOM 3595 C CG2 . ILE B 1 133 ? 71.094 101.432 -35.129 1.00 63.92 ? 126 ILE B CG2 1 ATOM 3596 C CD1 . ILE B 1 133 ? 67.963 101.639 -36.054 1.00 58.68 ? 126 ILE B CD1 1 ATOM 3597 N N . GLU B 1 134 ? 72.215 98.407 -34.312 1.00 56.00 ? 127 GLU B N 1 ATOM 3598 C CA . GLU B 1 134 ? 73.050 97.363 -34.911 1.00 55.60 ? 127 GLU B CA 1 ATOM 3599 C C . GLU B 1 134 ? 72.683 95.942 -34.447 1.00 62.74 ? 127 GLU B C 1 ATOM 3600 O O . GLU B 1 134 ? 72.896 94.986 -35.194 1.00 64.19 ? 127 GLU B O 1 ATOM 3601 C CB . GLU B 1 134 ? 74.545 97.635 -34.633 1.00 56.84 ? 127 GLU B CB 1 ATOM 3602 C CG . GLU B 1 134 ? 75.108 98.890 -35.300 1.00 63.81 ? 127 GLU B CG 1 ATOM 3603 C CD . GLU B 1 134 ? 75.082 100.186 -34.514 1.00 76.77 ? 127 GLU B CD 1 ATOM 3604 O OE1 . GLU B 1 134 ? 74.049 100.487 -33.875 1.00 64.54 ? 127 GLU B OE1 1 ATOM 3605 O OE2 . GLU B 1 134 ? 76.096 100.918 -34.563 1.00 74.69 ? 127 GLU B OE2 1 ATOM 3606 N N . GLN B 1 135 ? 72.138 95.796 -33.229 1.00 60.03 ? 128 GLN B N 1 ATOM 3607 C CA . GLN B 1 135 ? 71.761 94.482 -32.670 1.00 59.23 ? 128 GLN B CA 1 ATOM 3608 C C . GLN B 1 135 ? 70.233 94.268 -32.659 1.00 60.11 ? 128 GLN B C 1 ATOM 3609 O O . GLN B 1 135 ? 69.743 93.287 -32.088 1.00 58.40 ? 128 GLN B O 1 ATOM 3610 C CB . GLN B 1 135 ? 72.379 94.269 -31.261 1.00 60.68 ? 128 GLN B CB 1 ATOM 3611 C CG . GLN B 1 135 ? 73.913 94.291 -31.215 1.00 78.95 ? 128 GLN B CG 1 ATOM 3612 C CD . GLN B 1 135 ? 74.566 93.048 -31.772 1.00 108.49 ? 128 GLN B CD 1 ATOM 3613 O OE1 . GLN B 1 135 ? 74.534 91.966 -31.160 1.00 109.44 ? 128 GLN B OE1 1 ATOM 3614 N NE2 . GLN B 1 135 ? 75.231 93.187 -32.916 1.00 98.59 ? 128 GLN B NE2 1 ATOM 3615 N N . ALA B 1 136 ? 69.492 95.179 -33.309 1.00 56.35 ? 129 ALA B N 1 ATOM 3616 C CA . ALA B 1 136 ? 68.043 95.118 -33.376 1.00 56.81 ? 129 ALA B CA 1 ATOM 3617 C C . ALA B 1 136 ? 67.573 94.255 -34.543 1.00 65.79 ? 129 ALA B C 1 ATOM 3618 O O . ALA B 1 136 ? 67.960 94.484 -35.692 1.00 67.55 ? 129 ALA B O 1 ATOM 3619 C CB . ALA B 1 136 ? 67.457 96.520 -33.471 1.00 57.24 ? 129 ALA B CB 1 ATOM 3620 N N . ILE B 1 137 ? 66.731 93.259 -34.237 1.00 62.97 ? 130 ILE B N 1 ATOM 3621 C CA . ILE B 1 137 ? 66.141 92.335 -35.204 1.00 62.21 ? 130 ILE B CA 1 ATOM 3622 C C . ILE B 1 137 ? 65.113 93.117 -36.025 1.00 68.13 ? 130 ILE B C 1 ATOM 3623 O O . ILE B 1 137 ? 64.303 93.873 -35.468 1.00 67.47 ? 130 ILE B O 1 ATOM 3624 C CB . ILE B 1 137 ? 65.543 91.111 -34.472 1.00 64.73 ? 130 ILE B CB 1 ATOM 3625 C CG1 . ILE B 1 137 ? 66.590 90.427 -33.523 1.00 64.66 ? 130 ILE B CG1 1 ATOM 3626 C CG2 . ILE B 1 137 ? 64.865 90.114 -35.423 1.00 65.31 ? 130 ILE B CG2 1 ATOM 3627 C CD1 . ILE B 1 137 ? 67.830 89.796 -34.109 1.00 69.28 ? 130 ILE B CD1 1 ATOM 3628 N N . GLY B 1 138 ? 65.222 92.982 -37.346 1.00 65.57 ? 131 GLY B N 1 ATOM 3629 C CA . GLY B 1 138 ? 64.397 93.701 -38.308 1.00 64.89 ? 131 GLY B CA 1 ATOM 3630 C C . GLY B 1 138 ? 64.839 95.144 -38.453 1.00 67.62 ? 131 GLY B C 1 ATOM 3631 O O . GLY B 1 138 ? 64.162 95.931 -39.116 1.00 67.05 ? 131 GLY B O 1 ATOM 3632 N N . ARG B 1 139 ? 65.985 95.498 -37.829 1.00 65.00 ? 132 ARG B N 1 ATOM 3633 C CA . ARG B 1 139 ? 66.583 96.842 -37.784 1.00 66.33 ? 132 ARG B CA 1 ATOM 3634 C C . ARG B 1 139 ? 65.568 97.900 -37.338 1.00 71.07 ? 132 ARG B C 1 ATOM 3635 O O . ARG B 1 139 ? 65.483 98.994 -37.907 1.00 71.94 ? 132 ARG B O 1 ATOM 3636 C CB . ARG B 1 139 ? 67.302 97.225 -39.102 1.00 70.25 ? 132 ARG B CB 1 ATOM 3637 C CG . ARG B 1 139 ? 68.697 97.854 -38.902 1.00 90.51 ? 132 ARG B CG 1 ATOM 3638 C CD . ARG B 1 139 ? 69.700 96.884 -38.261 1.00 112.11 ? 132 ARG B CD 1 ATOM 3639 N NE . ARG B 1 139 ? 71.095 97.221 -38.567 1.00 128.19 ? 132 ARG B NE 1 ATOM 3640 C CZ . ARG B 1 139 ? 72.125 96.394 -38.392 1.00 142.19 ? 132 ARG B CZ 1 ATOM 3641 N NH1 . ARG B 1 139 ? 71.930 95.168 -37.912 1.00 131.19 ? 132 ARG B NH1 1 ATOM 3642 N NH2 . ARG B 1 139 ? 73.357 96.785 -38.697 1.00 122.13 ? 132 ARG B NH2 1 ATOM 3643 N N . VAL B 1 140 ? 64.786 97.541 -36.305 1.00 66.02 ? 133 VAL B N 1 ATOM 3644 C CA . VAL B 1 140 ? 63.756 98.380 -35.713 1.00 64.60 ? 133 VAL B CA 1 ATOM 3645 C C . VAL B 1 140 ? 64.473 99.359 -34.794 1.00 69.65 ? 133 VAL B C 1 ATOM 3646 O O . VAL B 1 140 ? 65.352 98.945 -34.024 1.00 70.13 ? 133 VAL B O 1 ATOM 3647 C CB . VAL B 1 140 ? 62.710 97.523 -34.951 1.00 67.03 ? 133 VAL B CB 1 ATOM 3648 C CG1 . VAL B 1 140 ? 61.610 98.391 -34.339 1.00 66.82 ? 133 VAL B CG1 1 ATOM 3649 C CG2 . VAL B 1 140 ? 62.105 96.464 -35.855 1.00 66.44 ? 133 VAL B CG2 1 ATOM 3650 N N . THR B 1 141 ? 64.116 100.653 -34.880 1.00 64.62 ? 134 THR B N 1 ATOM 3651 C CA . THR B 1 141 ? 64.715 101.685 -34.040 1.00 63.49 ? 134 THR B CA 1 ATOM 3652 C C . THR B 1 141 ? 64.518 101.359 -32.546 1.00 66.77 ? 134 THR B C 1 ATOM 3653 O O . THR B 1 141 ? 63.373 101.169 -32.119 1.00 67.20 ? 134 THR B O 1 ATOM 3654 C CB . THR B 1 141 ? 64.147 103.063 -34.404 1.00 65.86 ? 134 THR B CB 1 ATOM 3655 O OG1 . THR B 1 141 ? 64.387 103.315 -35.785 1.00 65.71 ? 134 THR B OG1 1 ATOM 3656 C CG2 . THR B 1 141 ? 64.762 104.167 -33.602 1.00 61.20 ? 134 THR B CG2 1 ATOM 3657 N N . PRO B 1 142 ? 65.605 101.280 -31.730 1.00 61.52 ? 135 PRO B N 1 ATOM 3658 C CA . PRO B 1 142 ? 65.411 101.031 -30.288 1.00 59.75 ? 135 PRO B CA 1 ATOM 3659 C C . PRO B 1 142 ? 64.749 102.245 -29.619 1.00 59.05 ? 135 PRO B C 1 ATOM 3660 O O . PRO B 1 142 ? 64.837 103.376 -30.123 1.00 58.16 ? 135 PRO B O 1 ATOM 3661 C CB . PRO B 1 142 ? 66.835 100.743 -29.771 1.00 61.25 ? 135 PRO B CB 1 ATOM 3662 C CG . PRO B 1 142 ? 67.691 100.582 -30.999 1.00 65.99 ? 135 PRO B CG 1 ATOM 3663 C CD . PRO B 1 142 ? 67.040 101.443 -32.042 1.00 62.38 ? 135 PRO B CD 1 ATOM 3664 N N . ILE B 1 143 ? 64.039 101.995 -28.514 1.00 52.60 ? 136 ILE B N 1 ATOM 3665 C CA . ILE B 1 143 ? 63.279 103.002 -27.760 1.00 50.65 ? 136 ILE B CA 1 ATOM 3666 C C . ILE B 1 143 ? 64.141 104.196 -27.323 1.00 54.38 ? 136 ILE B C 1 ATOM 3667 O O . ILE B 1 143 ? 63.661 105.325 -27.442 1.00 54.30 ? 136 ILE B O 1 ATOM 3668 C CB . ILE B 1 143 ? 62.479 102.360 -26.580 1.00 52.31 ? 136 ILE B CB 1 ATOM 3669 C CG1 . ILE B 1 143 ? 61.419 103.326 -26.011 1.00 51.21 ? 136 ILE B CG1 1 ATOM 3670 C CG2 . ILE B 1 143 ? 63.387 101.780 -25.489 1.00 52.05 ? 136 ILE B CG2 1 ATOM 3671 C CD1 . ILE B 1 143 ? 60.214 102.615 -25.373 1.00 51.72 ? 136 ILE B CD1 1 ATOM 3672 N N . PHE B 1 144 ? 65.403 103.967 -26.859 1.00 49.72 ? 137 PHE B N 1 ATOM 3673 C CA . PHE B 1 144 ? 66.268 105.079 -26.440 1.00 48.63 ? 137 PHE B CA 1 ATOM 3674 C C . PHE B 1 144 ? 66.597 106.006 -27.615 1.00 52.41 ? 137 PHE B C 1 ATOM 3675 O O . PHE B 1 144 ? 66.529 107.221 -27.455 1.00 50.82 ? 137 PHE B O 1 ATOM 3676 C CB . PHE B 1 144 ? 67.533 104.619 -25.677 1.00 49.24 ? 137 PHE B CB 1 ATOM 3677 C CG . PHE B 1 144 ? 68.194 105.745 -24.912 1.00 48.45 ? 137 PHE B CG 1 ATOM 3678 C CD1 . PHE B 1 144 ? 67.563 106.330 -23.815 1.00 49.62 ? 137 PHE B CD1 1 ATOM 3679 C CD2 . PHE B 1 144 ? 69.462 106.199 -25.267 1.00 48.34 ? 137 PHE B CD2 1 ATOM 3680 C CE1 . PHE B 1 144 ? 68.168 107.371 -23.111 1.00 49.39 ? 137 PHE B CE1 1 ATOM 3681 C CE2 . PHE B 1 144 ? 70.057 107.262 -24.578 1.00 49.93 ? 137 PHE B CE2 1 ATOM 3682 C CZ . PHE B 1 144 ? 69.401 107.847 -23.510 1.00 47.96 ? 137 PHE B CZ 1 ATOM 3683 N N . ASP B 1 145 ? 66.850 105.429 -28.808 1.00 51.34 ? 138 ASP B N 1 ATOM 3684 C CA . ASP B 1 145 ? 67.097 106.187 -30.053 1.00 51.38 ? 138 ASP B CA 1 ATOM 3685 C C . ASP B 1 145 ? 65.893 107.086 -30.375 1.00 55.30 ? 138 ASP B C 1 ATOM 3686 O O . ASP B 1 145 ? 66.081 108.274 -30.634 1.00 54.31 ? 138 ASP B O 1 ATOM 3687 C CB . ASP B 1 145 ? 67.439 105.238 -31.209 1.00 52.71 ? 138 ASP B CB 1 ATOM 3688 C CG . ASP B 1 145 ? 68.745 104.473 -31.032 1.00 66.03 ? 138 ASP B CG 1 ATOM 3689 O OD1 . ASP B 1 145 ? 68.978 103.934 -29.921 1.00 69.04 ? 138 ASP B OD1 1 ATOM 3690 O OD2 . ASP B 1 145 ? 69.513 104.377 -32.011 1.00 74.01 ? 138 ASP B OD2 1 ATOM 3691 N N . ASN B 1 146 ? 64.663 106.559 -30.211 1.00 52.23 ? 139 ASN B N 1 ATOM 3692 C CA . ASN B 1 146 ? 63.446 107.351 -30.412 1.00 52.26 ? 139 ASN B CA 1 ATOM 3693 C C . ASN B 1 146 ? 63.275 108.423 -29.321 1.00 58.01 ? 139 ASN B C 1 ATOM 3694 O O . ASN B 1 146 ? 62.807 109.530 -29.622 1.00 58.90 ? 139 ASN B O 1 ATOM 3695 C CB . ASN B 1 146 ? 62.185 106.461 -30.571 1.00 52.64 ? 139 ASN B CB 1 ATOM 3696 C CG . ASN B 1 146 ? 62.043 105.776 -31.917 1.00 69.21 ? 139 ASN B CG 1 ATOM 3697 O OD1 . ASN B 1 146 ? 62.221 106.382 -32.966 1.00 67.95 ? 139 ASN B OD1 1 ATOM 3698 N ND2 . ASN B 1 146 ? 61.705 104.497 -31.930 1.00 62.08 ? 139 ASN B ND2 1 ATOM 3699 N N . ILE B 1 147 ? 63.678 108.118 -28.066 1.00 55.07 ? 140 ILE B N 1 ATOM 3700 C CA . ILE B 1 147 ? 63.599 109.094 -26.960 1.00 54.88 ? 140 ILE B CA 1 ATOM 3701 C C . ILE B 1 147 ? 64.616 110.242 -27.195 1.00 60.55 ? 140 ILE B C 1 ATOM 3702 O O . ILE B 1 147 ? 64.255 111.421 -27.026 1.00 60.47 ? 140 ILE B O 1 ATOM 3703 C CB . ILE B 1 147 ? 63.698 108.423 -25.567 1.00 57.47 ? 140 ILE B CB 1 ATOM 3704 C CG1 . ILE B 1 147 ? 62.416 107.626 -25.249 1.00 57.80 ? 140 ILE B CG1 1 ATOM 3705 C CG2 . ILE B 1 147 ? 63.944 109.456 -24.471 1.00 57.80 ? 140 ILE B CG2 1 ATOM 3706 C CD1 . ILE B 1 147 ? 62.532 106.614 -24.128 1.00 62.45 ? 140 ILE B CD1 1 ATOM 3707 N N . ILE B 1 148 ? 65.866 109.891 -27.632 1.00 56.38 ? 141 ILE B N 1 ATOM 3708 C CA . ILE B 1 148 ? 66.917 110.852 -27.977 1.00 56.14 ? 141 ILE B CA 1 ATOM 3709 C C . ILE B 1 148 ? 66.336 111.807 -29.026 1.00 61.48 ? 141 ILE B C 1 ATOM 3710 O O . ILE B 1 148 ? 66.356 113.024 -28.810 1.00 61.85 ? 141 ILE B O 1 ATOM 3711 C CB . ILE B 1 148 ? 68.224 110.178 -28.519 1.00 58.97 ? 141 ILE B CB 1 ATOM 3712 C CG1 . ILE B 1 148 ? 68.894 109.217 -27.510 1.00 59.66 ? 141 ILE B CG1 1 ATOM 3713 C CG2 . ILE B 1 148 ? 69.224 111.214 -29.009 1.00 57.31 ? 141 ILE B CG2 1 ATOM 3714 C CD1 . ILE B 1 148 ? 69.908 108.129 -28.233 1.00 65.86 ? 141 ILE B CD1 1 ATOM 3715 N N . SER B 1 149 ? 65.770 111.245 -30.137 1.00 58.40 ? 142 SER B N 1 ATOM 3716 C CA . SER B 1 149 ? 65.174 112.010 -31.248 1.00 57.74 ? 142 SER B CA 1 ATOM 3717 C C . SER B 1 149 ? 64.226 113.116 -30.805 1.00 63.82 ? 142 SER B C 1 ATOM 3718 O O . SER B 1 149 ? 64.163 114.150 -31.475 1.00 65.15 ? 142 SER B O 1 ATOM 3719 C CB . SER B 1 149 ? 64.467 111.091 -32.232 1.00 59.09 ? 142 SER B CB 1 ATOM 3720 O OG . SER B 1 149 ? 65.393 110.272 -32.923 1.00 68.08 ? 142 SER B OG 1 ATOM 3721 N N . GLN B 1 150 ? 63.527 112.927 -29.660 1.00 58.68 ? 143 GLN B N 1 ATOM 3722 C CA . GLN B 1 150 ? 62.584 113.914 -29.140 1.00 57.65 ? 143 GLN B CA 1 ATOM 3723 C C . GLN B 1 150 ? 63.247 115.181 -28.601 1.00 59.79 ? 143 GLN B C 1 ATOM 3724 O O . GLN B 1 150 ? 62.548 116.173 -28.391 1.00 60.09 ? 143 GLN B O 1 ATOM 3725 C CB . GLN B 1 150 ? 61.650 113.303 -28.092 1.00 59.02 ? 143 GLN B CB 1 ATOM 3726 C CG . GLN B 1 150 ? 60.829 112.112 -28.578 1.00 66.70 ? 143 GLN B CG 1 ATOM 3727 C CD . GLN B 1 150 ? 59.839 111.658 -27.523 1.00 75.69 ? 143 GLN B CD 1 ATOM 3728 O OE1 . GLN B 1 150 ? 59.987 111.922 -26.321 1.00 58.43 ? 143 GLN B OE1 1 ATOM 3729 N NE2 . GLN B 1 150 ? 58.795 110.954 -27.942 1.00 72.99 ? 143 GLN B NE2 1 ATOM 3730 N N . GLY B 1 151 ? 64.565 115.137 -28.384 1.00 54.35 ? 144 GLY B N 1 ATOM 3731 C CA . GLY B 1 151 ? 65.363 116.262 -27.902 1.00 54.22 ? 144 GLY B CA 1 ATOM 3732 C C . GLY B 1 151 ? 64.864 116.867 -26.609 1.00 60.12 ? 144 GLY B C 1 ATOM 3733 O O . GLY B 1 151 ? 64.837 118.093 -26.444 1.00 60.21 ? 144 GLY B O 1 ATOM 3734 N N . VAL B 1 152 ? 64.463 115.992 -25.691 1.00 57.49 ? 145 VAL B N 1 ATOM 3735 C CA . VAL B 1 152 ? 63.876 116.372 -24.422 1.00 57.34 ? 145 VAL B CA 1 ATOM 3736 C C . VAL B 1 152 ? 64.810 116.015 -23.219 1.00 63.10 ? 145 VAL B C 1 ATOM 3737 O O . VAL B 1 152 ? 64.716 116.651 -22.166 1.00 62.85 ? 145 VAL B O 1 ATOM 3738 C CB . VAL B 1 152 ? 62.448 115.757 -24.364 1.00 59.59 ? 145 VAL B CB 1 ATOM 3739 C CG1 . VAL B 1 152 ? 62.356 114.505 -23.480 1.00 58.50 ? 145 VAL B CG1 1 ATOM 3740 C CG2 . VAL B 1 152 ? 61.411 116.808 -23.999 1.00 59.41 ? 145 VAL B CG2 1 ATOM 3741 N N . LEU B 1 153 ? 65.738 115.051 -23.407 1.00 59.17 ? 146 LEU B N 1 ATOM 3742 C CA . LEU B 1 153 ? 66.652 114.599 -22.360 1.00 58.73 ? 146 LEU B CA 1 ATOM 3743 C C . LEU B 1 153 ? 67.810 115.558 -22.086 1.00 60.79 ? 146 LEU B C 1 ATOM 3744 O O . LEU B 1 153 ? 68.429 116.063 -23.029 1.00 60.02 ? 146 LEU B O 1 ATOM 3745 C CB . LEU B 1 153 ? 67.212 113.200 -22.668 1.00 59.00 ? 146 LEU B CB 1 ATOM 3746 C CG . LEU B 1 153 ? 66.255 112.011 -22.661 1.00 64.12 ? 146 LEU B CG 1 ATOM 3747 C CD1 . LEU B 1 153 ? 67.026 110.738 -22.916 1.00 64.69 ? 146 LEU B CD1 1 ATOM 3748 C CD2 . LEU B 1 153 ? 65.459 111.901 -21.349 1.00 63.98 ? 146 LEU B CD2 1 ATOM 3749 N N . LYS B 1 154 ? 68.144 115.748 -20.788 1.00 54.88 ? 147 LYS B N 1 ATOM 3750 C CA . LYS B 1 154 ? 69.227 116.625 -20.350 1.00 53.77 ? 147 LYS B CA 1 ATOM 3751 C C . LYS B 1 154 ? 70.587 116.164 -20.944 1.00 55.00 ? 147 LYS B C 1 ATOM 3752 O O . LYS B 1 154 ? 71.383 116.996 -21.395 1.00 54.08 ? 147 LYS B O 1 ATOM 3753 C CB . LYS B 1 154 ? 69.245 116.722 -18.815 1.00 56.11 ? 147 LYS B CB 1 ATOM 3754 C CG . LYS B 1 154 ? 70.125 117.834 -18.289 1.00 82.70 ? 147 LYS B CG 1 ATOM 3755 C CD . LYS B 1 154 ? 69.405 118.684 -17.247 1.00 102.41 ? 147 LYS B CD 1 ATOM 3756 C CE . LYS B 1 154 ? 70.213 119.898 -16.846 1.00 121.09 ? 147 LYS B CE 1 ATOM 3757 N NZ . LYS B 1 154 ? 70.305 120.907 -17.942 1.00 132.28 ? 147 LYS B NZ 1 ATOM 3758 N N . GLU B 1 155 ? 70.792 114.829 -20.999 1.00 47.69 ? 148 GLU B N 1 ATOM 3759 C CA . GLU B 1 155 ? 71.969 114.164 -21.551 1.00 44.62 ? 148 GLU B CA 1 ATOM 3760 C C . GLU B 1 155 ? 71.546 112.922 -22.280 1.00 47.02 ? 148 GLU B C 1 ATOM 3761 O O . GLU B 1 155 ? 70.564 112.289 -21.911 1.00 46.82 ? 148 GLU B O 1 ATOM 3762 C CB . GLU B 1 155 ? 72.991 113.792 -20.452 1.00 44.84 ? 148 GLU B CB 1 ATOM 3763 C CG . GLU B 1 155 ? 73.785 114.971 -19.917 1.00 49.11 ? 148 GLU B CG 1 ATOM 3764 C CD . GLU B 1 155 ? 74.463 115.893 -20.938 1.00 82.13 ? 148 GLU B CD 1 ATOM 3765 O OE1 . GLU B 1 155 ? 74.912 115.398 -22.000 1.00 82.69 ? 148 GLU B OE1 1 ATOM 3766 O OE2 . GLU B 1 155 ? 74.502 117.123 -20.696 1.00 75.41 ? 148 GLU B OE2 1 ATOM 3767 N N . ASP B 1 156 ? 72.320 112.541 -23.282 1.00 45.28 ? 149 ASP B N 1 ATOM 3768 C CA . ASP B 1 156 ? 72.082 111.358 -24.114 1.00 45.38 ? 149 ASP B CA 1 ATOM 3769 C C . ASP B 1 156 ? 72.725 110.134 -23.411 1.00 45.29 ? 149 ASP B C 1 ATOM 3770 O O . ASP B 1 156 ? 73.618 109.459 -23.944 1.00 43.64 ? 149 ASP B O 1 ATOM 3771 C CB . ASP B 1 156 ? 72.606 111.661 -25.536 1.00 48.29 ? 149 ASP B CB 1 ATOM 3772 C CG . ASP B 1 156 ? 72.500 110.580 -26.588 1.00 72.72 ? 149 ASP B CG 1 ATOM 3773 O OD1 . ASP B 1 156 ? 71.916 109.508 -26.292 1.00 73.42 ? 149 ASP B OD1 1 ATOM 3774 O OD2 . ASP B 1 156 ? 73.043 110.788 -27.709 1.00 87.41 ? 149 ASP B OD2 1 ATOM 3775 N N . VAL B 1 157 ? 72.269 109.896 -22.151 1.00 40.50 ? 150 VAL B N 1 ATOM 3776 C CA . VAL B 1 157 ? 72.738 108.823 -21.248 1.00 38.57 ? 150 VAL B CA 1 ATOM 3777 C C . VAL B 1 157 ? 71.579 108.192 -20.455 1.00 41.13 ? 150 VAL B C 1 ATOM 3778 O O . VAL B 1 157 ? 70.541 108.831 -20.289 1.00 39.99 ? 150 VAL B O 1 ATOM 3779 C CB . VAL B 1 157 ? 73.870 109.287 -20.272 1.00 40.06 ? 150 VAL B CB 1 ATOM 3780 C CG1 . VAL B 1 157 ? 74.960 110.109 -20.971 1.00 38.98 ? 150 VAL B CG1 1 ATOM 3781 C CG2 . VAL B 1 157 ? 73.316 110.025 -19.060 1.00 39.12 ? 150 VAL B CG2 1 ATOM 3782 N N . PHE B 1 158 ? 71.780 106.970 -19.920 1.00 37.17 ? 151 PHE B N 1 ATOM 3783 C CA . PHE B 1 158 ? 70.826 106.314 -19.013 1.00 36.61 ? 151 PHE B CA 1 ATOM 3784 C C . PHE B 1 158 ? 71.572 105.555 -17.936 1.00 41.22 ? 151 PHE B C 1 ATOM 3785 O O . PHE B 1 158 ? 72.685 105.051 -18.201 1.00 39.35 ? 151 PHE B O 1 ATOM 3786 C CB . PHE B 1 158 ? 69.760 105.464 -19.726 1.00 37.75 ? 151 PHE B CB 1 ATOM 3787 C CG . PHE B 1 158 ? 70.297 104.352 -20.598 1.00 37.49 ? 151 PHE B CG 1 ATOM 3788 C CD1 . PHE B 1 158 ? 70.578 103.095 -20.061 1.00 37.74 ? 151 PHE B CD1 1 ATOM 3789 C CD2 . PHE B 1 158 ? 70.520 104.559 -21.960 1.00 36.76 ? 151 PHE B CD2 1 ATOM 3790 C CE1 . PHE B 1 158 ? 71.096 102.074 -20.868 1.00 38.01 ? 151 PHE B CE1 1 ATOM 3791 C CE2 . PHE B 1 158 ? 71.006 103.526 -22.770 1.00 38.43 ? 151 PHE B CE2 1 ATOM 3792 C CZ . PHE B 1 158 ? 71.298 102.293 -22.218 1.00 36.17 ? 151 PHE B CZ 1 ATOM 3793 N N . SER B 1 159 ? 70.979 105.474 -16.716 1.00 38.87 ? 152 SER B N 1 ATOM 3794 C CA . SER B 1 159 ? 71.644 104.886 -15.549 1.00 38.20 ? 152 SER B CA 1 ATOM 3795 C C . SER B 1 159 ? 70.864 103.818 -14.845 1.00 43.80 ? 152 SER B C 1 ATOM 3796 O O . SER B 1 159 ? 69.647 103.945 -14.678 1.00 42.82 ? 152 SER B O 1 ATOM 3797 C CB . SER B 1 159 ? 72.004 105.967 -14.538 1.00 39.20 ? 152 SER B CB 1 ATOM 3798 O OG . SER B 1 159 ? 72.929 106.901 -15.056 1.00 46.51 ? 152 SER B OG 1 ATOM 3799 N N . PHE B 1 160 ? 71.604 102.816 -14.321 1.00 40.50 ? 153 PHE B N 1 ATOM 3800 C CA . PHE B 1 160 ? 71.051 101.696 -13.572 1.00 40.38 ? 153 PHE B CA 1 ATOM 3801 C C . PHE B 1 160 ? 71.578 101.611 -12.178 1.00 42.59 ? 153 PHE B C 1 ATOM 3802 O O . PHE B 1 160 ? 72.801 101.695 -11.949 1.00 41.01 ? 153 PHE B O 1 ATOM 3803 C CB . PHE B 1 160 ? 71.335 100.359 -14.274 1.00 42.71 ? 153 PHE B CB 1 ATOM 3804 C CG . PHE B 1 160 ? 70.430 100.074 -15.448 1.00 45.24 ? 153 PHE B CG 1 ATOM 3805 C CD1 . PHE B 1 160 ? 70.565 100.789 -16.645 1.00 47.70 ? 153 PHE B CD1 1 ATOM 3806 C CD2 . PHE B 1 160 ? 69.479 99.062 -15.380 1.00 46.49 ? 153 PHE B CD2 1 ATOM 3807 C CE1 . PHE B 1 160 ? 69.747 100.514 -17.732 1.00 47.87 ? 153 PHE B CE1 1 ATOM 3808 C CE2 . PHE B 1 160 ? 68.653 98.799 -16.468 1.00 49.03 ? 153 PHE B CE2 1 ATOM 3809 C CZ . PHE B 1 160 ? 68.803 99.521 -17.639 1.00 46.85 ? 153 PHE B CZ 1 ATOM 3810 N N . TYR B 1 161 ? 70.626 101.413 -11.247 1.00 38.30 ? 154 TYR B N 1 ATOM 3811 C CA . TYR B 1 161 ? 70.825 101.133 -9.832 1.00 37.55 ? 154 TYR B CA 1 ATOM 3812 C C . TYR B 1 161 ? 70.049 99.841 -9.553 1.00 39.97 ? 154 TYR B C 1 ATOM 3813 O O . TYR B 1 161 ? 68.861 99.775 -9.857 1.00 41.07 ? 154 TYR B O 1 ATOM 3814 C CB . TYR B 1 161 ? 70.304 102.284 -8.927 1.00 37.83 ? 154 TYR B CB 1 ATOM 3815 C CG . TYR B 1 161 ? 70.214 101.892 -7.464 1.00 37.61 ? 154 TYR B CG 1 ATOM 3816 C CD1 . TYR B 1 161 ? 71.359 101.621 -6.724 1.00 39.58 ? 154 TYR B CD1 1 ATOM 3817 C CD2 . TYR B 1 161 ? 68.983 101.724 -6.841 1.00 37.33 ? 154 TYR B CD2 1 ATOM 3818 C CE1 . TYR B 1 161 ? 71.281 101.221 -5.392 1.00 40.20 ? 154 TYR B CE1 1 ATOM 3819 C CE2 . TYR B 1 161 ? 68.889 101.313 -5.512 1.00 36.96 ? 154 TYR B CE2 1 ATOM 3820 C CZ . TYR B 1 161 ? 70.041 101.074 -4.786 1.00 45.99 ? 154 TYR B CZ 1 ATOM 3821 O OH . TYR B 1 161 ? 69.962 100.674 -3.468 1.00 44.53 ? 154 TYR B OH 1 ATOM 3822 N N . TYR B 1 162 ? 70.719 98.819 -9.035 1.00 33.53 ? 155 TYR B N 1 ATOM 3823 C CA . TYR B 1 162 ? 70.117 97.544 -8.642 1.00 33.08 ? 155 TYR B CA 1 ATOM 3824 C C . TYR B 1 162 ? 70.464 97.380 -7.152 1.00 41.56 ? 155 TYR B C 1 ATOM 3825 O O . TYR B 1 162 ? 71.650 97.364 -6.798 1.00 42.90 ? 155 TYR B O 1 ATOM 3826 C CB . TYR B 1 162 ? 70.742 96.374 -9.412 1.00 33.40 ? 155 TYR B CB 1 ATOM 3827 C CG . TYR B 1 162 ? 70.232 96.121 -10.813 1.00 34.76 ? 155 TYR B CG 1 ATOM 3828 C CD1 . TYR B 1 162 ? 69.193 96.879 -11.350 1.00 36.46 ? 155 TYR B CD1 1 ATOM 3829 C CD2 . TYR B 1 162 ? 70.748 95.082 -11.588 1.00 34.34 ? 155 TYR B CD2 1 ATOM 3830 C CE1 . TYR B 1 162 ? 68.716 96.640 -12.637 1.00 35.36 ? 155 TYR B CE1 1 ATOM 3831 C CE2 . TYR B 1 162 ? 70.267 94.829 -12.873 1.00 33.85 ? 155 TYR B CE2 1 ATOM 3832 C CZ . TYR B 1 162 ? 69.240 95.600 -13.389 1.00 36.11 ? 155 TYR B CZ 1 ATOM 3833 O OH . TYR B 1 162 ? 68.743 95.351 -14.657 1.00 35.04 ? 155 TYR B OH 1 ATOM 3834 N N . ASN B 1 163 ? 69.455 97.303 -6.288 1.00 37.75 ? 156 ASN B N 1 ATOM 3835 C CA . ASN B 1 163 ? 69.639 97.159 -4.852 1.00 38.27 ? 156 ASN B CA 1 ATOM 3836 C C . ASN B 1 163 ? 69.763 95.681 -4.456 1.00 46.02 ? 156 ASN B C 1 ATOM 3837 O O . ASN B 1 163 ? 69.498 94.800 -5.270 1.00 43.44 ? 156 ASN B O 1 ATOM 3838 C CB . ASN B 1 163 ? 68.434 97.792 -4.139 1.00 41.42 ? 156 ASN B CB 1 ATOM 3839 C CG . ASN B 1 163 ? 68.577 98.057 -2.646 1.00 50.68 ? 156 ASN B CG 1 ATOM 3840 O OD1 . ASN B 1 163 ? 69.633 97.836 -2.018 1.00 35.50 ? 156 ASN B OD1 1 ATOM 3841 N ND2 . ASN B 1 163 ? 67.516 98.573 -2.054 1.00 32.12 ? 156 ASN B ND2 1 ATOM 3842 N N . ARG B 1 164 ? 70.200 95.423 -3.207 1.00 48.47 ? 157 ARG B N 1 ATOM 3843 C CA . ARG B 1 164 ? 70.295 94.106 -2.562 1.00 49.93 ? 157 ARG B CA 1 ATOM 3844 C C . ARG B 1 164 ? 68.895 93.851 -1.990 1.00 58.21 ? 157 ARG B C 1 ATOM 3845 O O . ARG B 1 164 ? 68.283 94.775 -1.476 1.00 57.68 ? 157 ARG B O 1 ATOM 3846 C CB . ARG B 1 164 ? 71.352 94.136 -1.428 1.00 48.59 ? 157 ARG B CB 1 ATOM 3847 C CG . ARG B 1 164 ? 72.784 94.041 -1.915 1.00 58.08 ? 157 ARG B CG 1 ATOM 3848 C CD . ARG B 1 164 ? 73.609 95.281 -1.634 1.00 67.51 ? 157 ARG B CD 1 ATOM 3849 N NE . ARG B 1 164 ? 74.934 95.184 -2.256 1.00 73.91 ? 157 ARG B NE 1 ATOM 3850 C CZ . ARG B 1 164 ? 75.831 96.172 -2.307 1.00 83.77 ? 157 ARG B CZ 1 ATOM 3851 N NH1 . ARG B 1 164 ? 75.569 97.350 -1.754 1.00 52.46 ? 157 ARG B NH1 1 ATOM 3852 N NH2 . ARG B 1 164 ? 76.993 95.987 -2.911 1.00 78.70 ? 157 ARG B NH2 1 ATOM 3853 N N . ASP B 1 165 ? 68.384 92.626 -2.107 1.00 60.83 ? 158 ASP B N 1 ATOM 3854 C CA . ASP B 1 165 ? 67.027 92.227 -1.687 1.00 64.26 ? 158 ASP B CA 1 ATOM 3855 C C . ASP B 1 165 ? 66.695 92.471 -0.207 1.00 73.22 ? 158 ASP B C 1 ATOM 3856 O O . ASP B 1 165 ? 67.601 92.504 0.640 1.00 72.61 ? 158 ASP B O 1 ATOM 3857 C CB . ASP B 1 165 ? 66.782 90.743 -2.029 1.00 67.26 ? 158 ASP B CB 1 ATOM 3858 C CG . ASP B 1 165 ? 65.338 90.306 -2.261 1.00 82.04 ? 158 ASP B CG 1 ATOM 3859 O OD1 . ASP B 1 165 ? 64.446 91.189 -2.340 1.00 80.91 ? 158 ASP B OD1 1 ATOM 3860 O OD2 . ASP B 1 165 ? 65.110 89.085 -2.407 1.00 93.23 ? 158 ASP B OD2 1 ATOM 3861 N N . SER B 1 166 ? 65.363 92.623 0.080 1.00 72.36 ? 159 SER B N 1 ATOM 3862 C CA . SER B 1 166 ? 64.764 92.846 1.403 1.00 109.26 ? 159 SER B CA 1 ATOM 3863 C C . SER B 1 166 ? 63.973 91.614 1.832 1.00 134.77 ? 159 SER B C 1 ATOM 3864 O O . SER B 1 166 ? 64.429 90.865 2.689 1.00 97.50 ? 159 SER B O 1 ATOM 3865 C CB . SER B 1 166 ? 63.841 94.061 1.377 1.00 112.67 ? 159 SER B CB 1 ATOM 3866 N N . GLN B 1 170 C 59.040 97.311 1.669 1.00 79.63 ? 160 GLN B N 1 ATOM 3867 C CA . GLN B 1 170 C 60.222 97.021 2.483 1.00 79.17 ? 160 GLN B CA 1 ATOM 3868 C C . GLN B 1 170 C 61.402 97.921 2.140 1.00 80.62 ? 160 GLN B C 1 ATOM 3869 O O . GLN B 1 170 C 62.059 98.416 3.068 1.00 80.48 ? 160 GLN B O 1 ATOM 3870 C CB . GLN B 1 170 C 60.635 95.548 2.350 1.00 80.87 ? 160 GLN B CB 1 ATOM 3871 N N . SER B 1 171 D 61.684 98.098 0.803 1.00 73.77 ? 160 SER B N 1 ATOM 3872 C CA . SER B 1 171 D 62.768 98.899 0.179 1.00 71.67 ? 160 SER B CA 1 ATOM 3873 C C . SER B 1 171 D 62.657 98.965 -1.363 1.00 70.63 ? 160 SER B C 1 ATOM 3874 O O . SER B 1 171 D 61.952 98.151 -1.976 1.00 71.69 ? 160 SER B O 1 ATOM 3875 C CB . SER B 1 171 D 64.160 98.386 0.574 1.00 74.75 ? 160 SER B CB 1 ATOM 3876 O OG . SER B 1 171 D 64.437 97.076 0.103 1.00 84.24 ? 160 SER B OG 1 ATOM 3877 N N . LEU B 1 172 ? 63.393 99.916 -1.981 1.00 60.40 ? 161 LEU B N 1 ATOM 3878 C CA . LEU B 1 172 ? 63.453 100.137 -3.427 1.00 56.20 ? 161 LEU B CA 1 ATOM 3879 C C . LEU B 1 172 ? 64.223 98.988 -4.081 1.00 53.39 ? 161 LEU B C 1 ATOM 3880 O O . LEU B 1 172 ? 65.346 98.694 -3.669 1.00 53.13 ? 161 LEU B O 1 ATOM 3881 C CB . LEU B 1 172 ? 64.175 101.481 -3.674 1.00 55.82 ? 161 LEU B CB 1 ATOM 3882 C CG . LEU B 1 172 ? 64.348 101.940 -5.108 1.00 60.89 ? 161 LEU B CG 1 ATOM 3883 C CD1 . LEU B 1 172 ? 63.114 102.597 -5.591 1.00 61.51 ? 161 LEU B CD1 1 ATOM 3884 C CD2 . LEU B 1 172 ? 65.482 102.931 -5.243 1.00 63.64 ? 161 LEU B CD2 1 ATOM 3885 N N . GLY B 1 173 ? 63.631 98.352 -5.082 1.00 44.62 ? 162 GLY B N 1 ATOM 3886 C CA . GLY B 1 173 ? 64.291 97.263 -5.794 1.00 42.61 ? 162 GLY B CA 1 ATOM 3887 C C . GLY B 1 173 ? 65.427 97.720 -6.693 1.00 42.82 ? 162 GLY B C 1 ATOM 3888 O O . GLY B 1 173 ? 66.440 97.033 -6.856 1.00 40.38 ? 162 GLY B O 1 ATOM 3889 N N . GLY B 1 174 ? 65.254 98.891 -7.274 1.00 38.57 ? 163 GLY B N 1 ATOM 3890 C CA . GLY B 1 174 ? 66.231 99.474 -8.175 1.00 37.61 ? 163 GLY B CA 1 ATOM 3891 C C . GLY B 1 174 ? 65.643 100.686 -8.843 1.00 42.36 ? 163 GLY B C 1 ATOM 3892 O O . GLY B 1 174 ? 64.517 101.076 -8.529 1.00 41.28 ? 163 GLY B O 1 ATOM 3893 N N . GLN B 1 175 ? 66.406 101.293 -9.760 1.00 39.86 ? 164 GLN B N 1 ATOM 3894 C CA . GLN B 1 175 ? 66.004 102.498 -10.476 1.00 39.09 ? 164 GLN B CA 1 ATOM 3895 C C . GLN B 1 175 ? 66.791 102.689 -11.777 1.00 43.99 ? 164 GLN B C 1 ATOM 3896 O O . GLN B 1 175 ? 68.013 102.500 -11.801 1.00 42.92 ? 164 GLN B O 1 ATOM 3897 C CB . GLN B 1 175 ? 66.190 103.718 -9.564 1.00 39.63 ? 164 GLN B CB 1 ATOM 3898 C CG . GLN B 1 175 ? 65.602 105.022 -10.109 1.00 41.37 ? 164 GLN B CG 1 ATOM 3899 C CD . GLN B 1 175 ? 66.169 106.247 -9.447 1.00 56.93 ? 164 GLN B CD 1 ATOM 3900 O OE1 . GLN B 1 175 ? 65.439 107.145 -9.051 1.00 53.03 ? 164 GLN B OE1 1 ATOM 3901 N NE2 . GLN B 1 175 ? 67.478 106.326 -9.322 1.00 48.49 ? 164 GLN B NE2 1 ATOM 3902 N N . ILE B 1 176 ? 66.075 103.098 -12.845 1.00 41.95 ? 165 ILE B N 1 ATOM 3903 C CA . ILE B 1 176 ? 66.635 103.475 -14.151 1.00 42.42 ? 165 ILE B CA 1 ATOM 3904 C C . ILE B 1 176 ? 66.347 104.941 -14.300 1.00 46.08 ? 165 ILE B C 1 ATOM 3905 O O . ILE B 1 176 ? 65.229 105.363 -14.053 1.00 45.98 ? 165 ILE B O 1 ATOM 3906 C CB . ILE B 1 176 ? 66.062 102.615 -15.331 1.00 46.46 ? 165 ILE B CB 1 ATOM 3907 C CG1 . ILE B 1 176 ? 66.691 102.924 -16.738 1.00 46.33 ? 165 ILE B CG1 1 ATOM 3908 C CG2 . ILE B 1 176 ? 64.538 102.633 -15.429 1.00 48.92 ? 165 ILE B CG2 1 ATOM 3909 C CD1 . ILE B 1 176 ? 66.084 102.060 -18.005 1.00 61.89 ? 165 ILE B CD1 1 ATOM 3910 N N . VAL B 1 177 ? 67.377 105.732 -14.597 1.00 43.14 ? 166 VAL B N 1 ATOM 3911 C CA . VAL B 1 177 ? 67.238 107.162 -14.892 1.00 41.28 ? 166 VAL B CA 1 ATOM 3912 C C . VAL B 1 177 ? 67.537 107.303 -16.386 1.00 43.49 ? 166 VAL B C 1 ATOM 3913 O O . VAL B 1 177 ? 68.570 106.841 -16.846 1.00 43.10 ? 166 VAL B O 1 ATOM 3914 C CB . VAL B 1 177 ? 68.160 108.088 -14.046 1.00 42.98 ? 166 VAL B CB 1 ATOM 3915 C CG1 . VAL B 1 177 ? 67.952 109.549 -14.408 1.00 41.71 ? 166 VAL B CG1 1 ATOM 3916 C CG2 . VAL B 1 177 ? 67.970 107.866 -12.553 1.00 42.59 ? 166 VAL B CG2 1 ATOM 3917 N N . LEU B 1 178 ? 66.633 107.913 -17.137 1.00 41.26 ? 167 LEU B N 1 ATOM 3918 C CA . LEU B 1 178 ? 66.827 108.240 -18.569 1.00 40.35 ? 167 LEU B CA 1 ATOM 3919 C C . LEU B 1 178 ? 67.204 109.729 -18.657 1.00 41.99 ? 167 LEU B C 1 ATOM 3920 O O . LEU B 1 178 ? 66.521 110.561 -18.078 1.00 42.10 ? 167 LEU B O 1 ATOM 3921 C CB . LEU B 1 178 ? 65.549 107.975 -19.383 1.00 40.54 ? 167 LEU B CB 1 ATOM 3922 C CG . LEU B 1 178 ? 65.006 106.540 -19.393 1.00 44.63 ? 167 LEU B CG 1 ATOM 3923 C CD1 . LEU B 1 178 ? 63.616 106.533 -19.934 1.00 45.68 ? 167 LEU B CD1 1 ATOM 3924 C CD2 . LEU B 1 178 ? 65.887 105.616 -20.210 1.00 44.22 ? 167 LEU B CD2 1 ATOM 3925 N N . GLY B 1 179 ? 68.322 110.037 -19.291 1.00 38.55 ? 168 GLY B N 1 ATOM 3926 C CA . GLY B 1 179 ? 68.808 111.410 -19.426 1.00 39.19 ? 168 GLY B CA 1 ATOM 3927 C C . GLY B 1 179 ? 69.803 111.873 -18.372 1.00 43.66 ? 168 GLY B C 1 ATOM 3928 O O . GLY B 1 179 ? 70.205 113.036 -18.373 1.00 42.54 ? 168 GLY B O 1 ATOM 3929 N N . GLY B 1 180 ? 70.190 110.974 -17.472 1.00 40.34 ? 169 GLY B N 1 ATOM 3930 C CA . GLY B 1 180 ? 71.118 111.292 -16.400 1.00 39.54 ? 169 GLY B CA 1 ATOM 3931 C C . GLY B 1 180 ? 71.363 110.147 -15.451 1.00 45.49 ? 169 GLY B C 1 ATOM 3932 O O . GLY B 1 180 ? 71.254 108.979 -15.844 1.00 46.84 ? 169 GLY B O 1 ATOM 3933 N N . SER B 1 181 ? 71.684 110.489 -14.187 1.00 41.88 ? 170 SER B N 1 ATOM 3934 C CA . SER B 1 181 ? 71.995 109.584 -13.079 1.00 41.52 ? 170 SER B CA 1 ATOM 3935 C C . SER B 1 181 ? 71.466 110.153 -11.750 1.00 46.21 ? 170 SER B C 1 ATOM 3936 O O . SER B 1 181 ? 71.257 111.356 -11.643 1.00 45.77 ? 170 SER B O 1 ATOM 3937 C CB . SER B 1 181 ? 73.504 109.379 -12.984 1.00 44.69 ? 170 SER B CB 1 ATOM 3938 O OG . SER B 1 181 ? 74.142 110.549 -12.498 1.00 53.31 ? 170 SER B OG 1 ATOM 3939 N N . ASP B 1 182 ? 71.242 109.288 -10.742 1.00 44.12 ? 171 ASP B N 1 ATOM 3940 C CA . ASP B 1 182 ? 70.766 109.718 -9.424 1.00 44.00 ? 171 ASP B CA 1 ATOM 3941 C C . ASP B 1 182 ? 71.904 109.628 -8.402 1.00 44.77 ? 171 ASP B C 1 ATOM 3942 O O . ASP B 1 182 ? 72.309 108.527 -8.038 1.00 43.85 ? 171 ASP B O 1 ATOM 3943 C CB . ASP B 1 182 ? 69.543 108.910 -8.972 1.00 46.33 ? 171 ASP B CB 1 ATOM 3944 C CG . ASP B 1 182 ? 68.905 109.370 -7.677 1.00 57.42 ? 171 ASP B CG 1 ATOM 3945 O OD1 . ASP B 1 182 ? 69.499 110.238 -6.988 1.00 62.15 ? 171 ASP B OD1 1 ATOM 3946 O OD2 . ASP B 1 182 ? 67.809 108.884 -7.359 1.00 57.89 ? 171 ASP B OD2 1 ATOM 3947 N N . PRO B 1 183 ? 72.405 110.794 -7.924 1.00 39.70 ? 172 PRO B N 1 ATOM 3948 C CA . PRO B 1 183 ? 73.541 110.787 -6.972 1.00 38.38 ? 172 PRO B CA 1 ATOM 3949 C C . PRO B 1 183 ? 73.212 110.196 -5.607 1.00 42.88 ? 172 PRO B C 1 ATOM 3950 O O . PRO B 1 183 ? 74.122 109.776 -4.900 1.00 43.47 ? 172 PRO B O 1 ATOM 3951 C CB . PRO B 1 183 ? 73.963 112.261 -6.885 1.00 39.31 ? 172 PRO B CB 1 ATOM 3952 C CG . PRO B 1 183 ? 73.215 112.972 -7.947 1.00 42.64 ? 172 PRO B CG 1 ATOM 3953 C CD . PRO B 1 183 ? 72.001 112.176 -8.272 1.00 38.96 ? 172 PRO B CD 1 ATOM 3954 N N . GLN B 1 184 ? 71.920 110.099 -5.260 1.00 39.28 ? 173 GLN B N 1 ATOM 3955 C CA . GLN B 1 184 ? 71.505 109.465 -4.001 1.00 38.93 ? 173 GLN B CA 1 ATOM 3956 C C . GLN B 1 184 ? 71.822 107.949 -3.978 1.00 40.59 ? 173 GLN B C 1 ATOM 3957 O O . GLN B 1 184 ? 71.831 107.352 -2.891 1.00 38.90 ? 173 GLN B O 1 ATOM 3958 C CB . GLN B 1 184 ? 70.004 109.718 -3.711 1.00 40.17 ? 173 GLN B CB 1 ATOM 3959 C CG . GLN B 1 184 ? 69.626 111.211 -3.605 1.00 70.19 ? 173 GLN B CG 1 ATOM 3960 C CD . GLN B 1 184 ? 70.449 111.999 -2.597 1.00 102.22 ? 173 GLN B CD 1 ATOM 3961 O OE1 . GLN B 1 184 ? 70.284 111.845 -1.375 1.00 101.67 ? 173 GLN B OE1 1 ATOM 3962 N NE2 . GLN B 1 184 ? 71.342 112.874 -3.088 1.00 88.77 ? 173 GLN B NE2 1 ATOM 3963 N N . HIS B 1 185 ? 72.121 107.343 -5.173 1.00 36.51 ? 174 HIS B N 1 ATOM 3964 C CA . HIS B 1 185 ? 72.404 105.914 -5.289 1.00 36.15 ? 174 HIS B CA 1 ATOM 3965 C C . HIS B 1 185 ? 73.848 105.579 -5.624 1.00 42.82 ? 174 HIS B C 1 ATOM 3966 O O . HIS B 1 185 ? 74.154 104.399 -5.720 1.00 42.63 ? 174 HIS B O 1 ATOM 3967 C CB . HIS B 1 185 ? 71.434 105.223 -6.219 1.00 36.45 ? 174 HIS B CB 1 ATOM 3968 C CG . HIS B 1 185 ? 70.035 105.247 -5.666 1.00 39.28 ? 174 HIS B CG 1 ATOM 3969 N ND1 . HIS B 1 185 ? 69.749 104.753 -4.398 1.00 40.51 ? 174 HIS B ND1 1 ATOM 3970 C CD2 . HIS B 1 185 ? 68.903 105.758 -6.200 1.00 41.09 ? 174 HIS B CD2 1 ATOM 3971 C CE1 . HIS B 1 185 ? 68.463 104.967 -4.208 1.00 40.18 ? 174 HIS B CE1 1 ATOM 3972 N NE2 . HIS B 1 185 ? 67.905 105.565 -5.263 1.00 40.98 ? 174 HIS B NE2 1 ATOM 3973 N N . TYR B 1 186 ? 74.772 106.570 -5.616 1.00 40.29 ? 175 TYR B N 1 ATOM 3974 C CA . TYR B 1 186 ? 76.202 106.298 -5.756 1.00 39.00 ? 175 TYR B CA 1 ATOM 3975 C C . TYR B 1 186 ? 77.054 107.235 -4.890 1.00 44.05 ? 175 TYR B C 1 ATOM 3976 O O . TYR B 1 186 ? 76.623 108.325 -4.490 1.00 41.46 ? 175 TYR B O 1 ATOM 3977 C CB . TYR B 1 186 ? 76.702 106.248 -7.222 1.00 38.14 ? 175 TYR B CB 1 ATOM 3978 C CG . TYR B 1 186 ? 76.494 107.512 -8.016 1.00 38.31 ? 175 TYR B CG 1 ATOM 3979 C CD1 . TYR B 1 186 ? 75.322 107.720 -8.733 1.00 40.86 ? 175 TYR B CD1 1 ATOM 3980 C CD2 . TYR B 1 186 ? 77.504 108.469 -8.123 1.00 37.71 ? 175 TYR B CD2 1 ATOM 3981 C CE1 . TYR B 1 186 ? 75.134 108.873 -9.498 1.00 41.45 ? 175 TYR B CE1 1 ATOM 3982 C CE2 . TYR B 1 186 ? 77.326 109.625 -8.882 1.00 37.81 ? 175 TYR B CE2 1 ATOM 3983 C CZ . TYR B 1 186 ? 76.130 109.833 -9.555 1.00 42.90 ? 175 TYR B CZ 1 ATOM 3984 O OH . TYR B 1 186 ? 75.895 110.988 -10.264 1.00 41.16 ? 175 TYR B OH 1 ATOM 3985 N N . GLU B 1 187 ? 78.277 106.771 -4.618 1.00 43.28 ? 176 GLU B N 1 ATOM 3986 C CA . GLU B 1 187 ? 79.317 107.450 -3.857 1.00 44.40 ? 176 GLU B CA 1 ATOM 3987 C C . GLU B 1 187 ? 80.351 107.950 -4.816 1.00 47.67 ? 176 GLU B C 1 ATOM 3988 O O . GLU B 1 187 ? 80.787 107.196 -5.702 1.00 45.57 ? 176 GLU B O 1 ATOM 3989 C CB . GLU B 1 187 ? 80.019 106.465 -2.893 1.00 46.37 ? 176 GLU B CB 1 ATOM 3990 C CG . GLU B 1 187 ? 79.291 106.252 -1.579 1.00 62.64 ? 176 GLU B CG 1 ATOM 3991 C CD . GLU B 1 187 ? 79.874 105.115 -0.765 1.00 94.72 ? 176 GLU B CD 1 ATOM 3992 O OE1 . GLU B 1 187 ? 79.099 104.230 -0.328 1.00 70.60 ? 176 GLU B OE1 1 ATOM 3993 O OE2 . GLU B 1 187 ? 81.117 105.090 -0.602 1.00 102.28 ? 176 GLU B OE2 1 ATOM 3994 N N . GLY B 1 188 ? 80.760 109.204 -4.615 1.00 45.73 ? 177 GLY B N 1 ATOM 3995 C CA . GLY B 1 188 ? 81.828 109.819 -5.392 1.00 45.60 ? 177 GLY B CA 1 ATOM 3996 C C . GLY B 1 188 ? 81.547 110.058 -6.861 1.00 48.75 ? 177 GLY B C 1 ATOM 3997 O O . GLY B 1 188 ? 80.415 110.358 -7.256 1.00 46.59 ? 177 GLY B O 1 ATOM 3998 N N . ASN B 1 189 ? 82.601 109.926 -7.674 1.00 45.53 ? 178 ASN B N 1 ATOM 3999 C CA . ASN B 1 189 ? 82.551 110.208 -9.115 1.00 42.85 ? 178 ASN B CA 1 ATOM 4000 C C . ASN B 1 189 ? 82.745 108.987 -9.977 1.00 43.43 ? 178 ASN B C 1 ATOM 4001 O O . ASN B 1 189 ? 83.407 108.015 -9.602 1.00 42.50 ? 178 ASN B O 1 ATOM 4002 C CB . ASN B 1 189 ? 83.552 111.326 -9.533 1.00 34.52 ? 178 ASN B CB 1 ATOM 4003 C CG . ASN B 1 189 ? 83.391 112.616 -8.760 1.00 52.76 ? 178 ASN B CG 1 ATOM 4004 O OD1 . ASN B 1 189 ? 82.412 113.369 -8.904 1.00 52.84 ? 178 ASN B OD1 1 ATOM 4005 N ND2 . ASN B 1 189 ? 84.351 112.883 -7.905 1.00 39.31 ? 178 ASN B ND2 1 ATOM 4006 N N . PHE B 1 190 ? 82.158 109.068 -11.162 1.00 38.83 ? 179 PHE B N 1 ATOM 4007 C CA . PHE B 1 190 ? 82.219 108.054 -12.194 1.00 38.22 ? 179 PHE B CA 1 ATOM 4008 C C . PHE B 1 190 ? 83.614 107.987 -12.814 1.00 42.49 ? 179 PHE B C 1 ATOM 4009 O O . PHE B 1 190 ? 84.257 109.018 -13.010 1.00 42.89 ? 179 PHE B O 1 ATOM 4010 C CB . PHE B 1 190 ? 81.208 108.412 -13.308 1.00 39.31 ? 179 PHE B CB 1 ATOM 4011 C CG . PHE B 1 190 ? 79.781 108.018 -13.027 1.00 41.58 ? 179 PHE B CG 1 ATOM 4012 C CD1 . PHE B 1 190 ? 79.422 106.679 -12.904 1.00 45.22 ? 179 PHE B CD1 1 ATOM 4013 C CD2 . PHE B 1 190 ? 78.785 108.979 -12.922 1.00 43.88 ? 179 PHE B CD2 1 ATOM 4014 C CE1 . PHE B 1 190 ? 78.100 106.309 -12.615 1.00 45.38 ? 179 PHE B CE1 1 ATOM 4015 C CE2 . PHE B 1 190 ? 77.463 108.605 -12.659 1.00 46.52 ? 179 PHE B CE2 1 ATOM 4016 C CZ . PHE B 1 190 ? 77.134 107.272 -12.506 1.00 44.35 ? 179 PHE B CZ 1 ATOM 4017 N N . HIS B 1 191 ? 84.071 106.795 -13.127 1.00 38.03 ? 180 HIS B N 1 ATOM 4018 C CA . HIS B 1 191 ? 85.226 106.570 -13.963 1.00 38.91 ? 180 HIS B CA 1 ATOM 4019 C C . HIS B 1 191 ? 84.607 105.814 -15.151 1.00 40.59 ? 180 HIS B C 1 ATOM 4020 O O . HIS B 1 191 ? 83.766 104.943 -14.954 1.00 38.99 ? 180 HIS B O 1 ATOM 4021 C CB . HIS B 1 191 ? 86.388 105.809 -13.298 1.00 40.80 ? 180 HIS B CB 1 ATOM 4022 C CG . HIS B 1 191 ? 87.398 105.256 -14.284 1.00 46.09 ? 180 HIS B CG 1 ATOM 4023 N ND1 . HIS B 1 191 ? 88.466 106.038 -14.768 1.00 48.29 ? 180 HIS B ND1 1 ATOM 4024 C CD2 . HIS B 1 191 ? 87.477 104.021 -14.856 1.00 48.69 ? 180 HIS B CD2 1 ATOM 4025 C CE1 . HIS B 1 191 ? 89.149 105.248 -15.593 1.00 47.62 ? 180 HIS B CE1 1 ATOM 4026 N NE2 . HIS B 1 191 ? 88.596 104.032 -15.689 1.00 48.16 ? 180 HIS B NE2 1 ATOM 4027 N N . TYR B 1 192 ? 84.984 106.188 -16.370 1.00 36.82 ? 181 TYR B N 1 ATOM 4028 C CA . TYR B 1 192 ? 84.459 105.627 -17.617 1.00 35.56 ? 181 TYR B CA 1 ATOM 4029 C C . TYR B 1 192 ? 85.449 104.731 -18.332 1.00 41.51 ? 181 TYR B C 1 ATOM 4030 O O . TYR B 1 192 ? 86.656 104.812 -18.101 1.00 44.19 ? 181 TYR B O 1 ATOM 4031 C CB . TYR B 1 192 ? 84.020 106.752 -18.549 1.00 35.25 ? 181 TYR B CB 1 ATOM 4032 C CG . TYR B 1 192 ? 82.961 107.668 -17.956 1.00 34.94 ? 181 TYR B CG 1 ATOM 4033 C CD1 . TYR B 1 192 ? 83.310 108.746 -17.142 1.00 35.30 ? 181 TYR B CD1 1 ATOM 4034 C CD2 . TYR B 1 192 ? 81.607 107.463 -18.222 1.00 34.19 ? 181 TYR B CD2 1 ATOM 4035 C CE1 . TYR B 1 192 ? 82.333 109.586 -16.603 1.00 37.30 ? 181 TYR B CE1 1 ATOM 4036 C CE2 . TYR B 1 192 ? 80.626 108.287 -17.674 1.00 32.72 ? 181 TYR B CE2 1 ATOM 4037 C CZ . TYR B 1 192 ? 80.991 109.345 -16.867 1.00 38.99 ? 181 TYR B CZ 1 ATOM 4038 O OH . TYR B 1 192 ? 80.025 110.160 -16.341 1.00 42.14 ? 181 TYR B OH 1 ATOM 4039 N N . ILE B 1 193 ? 84.924 103.845 -19.172 1.00 36.83 ? 182 ILE B N 1 ATOM 4040 C CA . ILE B 1 193 ? 85.647 102.893 -20.001 1.00 36.76 ? 182 ILE B CA 1 ATOM 4041 C C . ILE B 1 193 ? 84.960 102.991 -21.354 1.00 42.81 ? 182 ILE B C 1 ATOM 4042 O O . ILE B 1 193 ? 83.749 102.842 -21.411 1.00 39.49 ? 182 ILE B O 1 ATOM 4043 C CB . ILE B 1 193 ? 85.627 101.435 -19.436 1.00 39.59 ? 182 ILE B CB 1 ATOM 4044 C CG1 . ILE B 1 193 ? 86.134 101.372 -17.986 1.00 39.79 ? 182 ILE B CG1 1 ATOM 4045 C CG2 . ILE B 1 193 ? 86.415 100.453 -20.310 1.00 39.29 ? 182 ILE B CG2 1 ATOM 4046 C CD1 . ILE B 1 193 ? 85.005 101.364 -16.960 1.00 44.12 ? 182 ILE B CD1 1 ATOM 4047 N N . ASN B 1 194 ? 85.716 103.299 -22.433 1.00 44.47 ? 183 ASN B N 1 ATOM 4048 C CA . ASN B 1 194 ? 85.127 103.437 -23.768 1.00 45.66 ? 183 ASN B CA 1 ATOM 4049 C C . ASN B 1 194 ? 84.775 102.104 -24.374 1.00 49.37 ? 183 ASN B C 1 ATOM 4050 O O . ASN B 1 194 ? 85.456 101.109 -24.119 1.00 48.91 ? 183 ASN B O 1 ATOM 4051 C CB . ASN B 1 194 ? 86.016 104.256 -24.719 1.00 50.00 ? 183 ASN B CB 1 ATOM 4052 C CG . ASN B 1 194 ? 86.347 105.648 -24.238 1.00 72.49 ? 183 ASN B CG 1 ATOM 4053 O OD1 . ASN B 1 194 ? 87.517 106.024 -24.183 1.00 70.94 ? 183 ASN B OD1 1 ATOM 4054 N ND2 . ASN B 1 194 ? 85.338 106.459 -23.896 1.00 62.01 ? 183 ASN B ND2 1 ATOM 4055 N N . LEU B 1 195 ? 83.691 102.075 -25.162 1.00 46.14 ? 184 LEU B N 1 ATOM 4056 C CA . LEU B 1 195 ? 83.274 100.856 -25.854 1.00 46.27 ? 184 LEU B CA 1 ATOM 4057 C C . LEU B 1 195 ? 84.332 100.504 -26.896 1.00 52.63 ? 184 LEU B C 1 ATOM 4058 O O . LEU B 1 195 ? 84.979 101.403 -27.450 1.00 52.45 ? 184 LEU B O 1 ATOM 4059 C CB . LEU B 1 195 ? 81.909 101.039 -26.548 1.00 45.73 ? 184 LEU B CB 1 ATOM 4060 C CG . LEU B 1 195 ? 80.711 101.434 -25.688 1.00 49.42 ? 184 LEU B CG 1 ATOM 4061 C CD1 . LEU B 1 195 ? 79.471 101.540 -26.541 1.00 49.53 ? 184 LEU B CD1 1 ATOM 4062 C CD2 . LEU B 1 195 ? 80.477 100.463 -24.547 1.00 47.36 ? 184 LEU B CD2 1 ATOM 4063 N N . ILE B 1 196 ? 84.516 99.213 -27.154 1.00 51.28 ? 185 ILE B N 1 ATOM 4064 C CA . ILE B 1 196 ? 85.469 98.747 -28.164 1.00 51.99 ? 185 ILE B CA 1 ATOM 4065 C C . ILE B 1 196 ? 85.014 99.260 -29.537 1.00 57.63 ? 185 ILE B C 1 ATOM 4066 O O . ILE B 1 196 ? 85.782 99.904 -30.249 1.00 59.97 ? 185 ILE B O 1 ATOM 4067 C CB . ILE B 1 196 ? 85.602 97.216 -28.100 1.00 55.12 ? 185 ILE B CB 1 ATOM 4068 C CG1 . ILE B 1 196 ? 86.328 96.804 -26.813 1.00 54.97 ? 185 ILE B CG1 1 ATOM 4069 C CG2 . ILE B 1 196 ? 86.293 96.668 -29.380 1.00 56.40 ? 185 ILE B CG2 1 ATOM 4070 C CD1 . ILE B 1 196 ? 86.038 95.448 -26.384 1.00 61.46 ? 185 ILE B CD1 1 ATOM 4071 N N . LYS B 1 197 ? 83.742 99.034 -29.853 1.00 52.55 ? 186 LYS B N 1 ATOM 4072 C CA . LYS B 1 197 ? 83.077 99.490 -31.055 1.00 51.86 ? 186 LYS B CA 1 ATOM 4073 C C . LYS B 1 197 ? 81.649 99.836 -30.685 1.00 56.43 ? 186 LYS B C 1 ATOM 4074 O O . LYS B 1 197 ? 81.061 99.191 -29.807 1.00 57.43 ? 186 LYS B O 1 ATOM 4075 C CB . LYS B 1 197 ? 83.107 98.403 -32.164 1.00 54.34 ? 186 LYS B CB 1 ATOM 4076 C CG . LYS B 1 197 ? 82.369 97.105 -31.822 1.00 72.30 ? 186 LYS B CG 1 ATOM 4077 C CD . LYS B 1 197 ? 82.590 95.975 -32.823 1.00 72.02 ? 186 LYS B CD 1 ATOM 4078 C CE . LYS B 1 197 ? 81.773 94.742 -32.467 1.00 79.10 ? 186 LYS B CE 1 ATOM 4079 N NZ . LYS B 1 197 ? 82.185 94.110 -31.169 1.00 92.10 ? 186 LYS B NZ 1 ATOM 4080 N N . THR B 1 198 ? 81.081 100.836 -31.361 1.00 53.38 ? 187 THR B N 1 ATOM 4081 C CA . THR B 1 198 ? 79.668 101.209 -31.218 1.00 52.80 ? 187 THR B CA 1 ATOM 4082 C C . THR B 1 198 ? 78.793 100.015 -31.712 1.00 55.29 ? 187 THR B C 1 ATOM 4083 O O . THR B 1 198 ? 79.269 99.160 -32.479 1.00 54.02 ? 187 THR B O 1 ATOM 4084 C CB . THR B 1 198 ? 79.371 102.543 -31.936 1.00 57.92 ? 187 THR B CB 1 ATOM 4085 O OG1 . THR B 1 198 ? 78.066 102.969 -31.568 1.00 63.26 ? 187 THR B OG1 1 ATOM 4086 C CG2 . THR B 1 198 ? 79.478 102.447 -33.466 1.00 50.67 ? 187 THR B CG2 1 ATOM 4087 N N . GLY B 1 199 ? 77.553 99.955 -31.237 1.00 51.78 ? 188 GLY B N 1 ATOM 4088 C CA . GLY B 1 199 ? 76.635 98.885 -31.617 1.00 50.88 ? 188 GLY B CA 1 ATOM 4089 C C . GLY B 1 199 ? 76.406 97.840 -30.550 1.00 51.78 ? 188 GLY B C 1 ATOM 4090 O O . GLY B 1 199 ? 75.397 97.138 -30.592 1.00 51.74 ? 188 GLY B O 1 ATOM 4091 N N . VAL B 1 200 ? 77.317 97.751 -29.572 1.00 46.35 ? 189 VAL B N 1 ATOM 4092 C CA . VAL B 1 200 ? 77.237 96.785 -28.465 1.00 45.60 ? 189 VAL B CA 1 ATOM 4093 C C . VAL B 1 200 ? 77.824 97.421 -27.187 1.00 47.97 ? 189 VAL B C 1 ATOM 4094 O O . VAL B 1 200 ? 78.831 98.138 -27.263 1.00 49.57 ? 189 VAL B O 1 ATOM 4095 C CB . VAL B 1 200 ? 77.869 95.394 -28.871 1.00 48.72 ? 189 VAL B CB 1 ATOM 4096 C CG1 . VAL B 1 200 ? 79.273 95.532 -29.443 1.00 48.84 ? 189 VAL B CG1 1 ATOM 4097 C CG2 . VAL B 1 200 ? 77.838 94.372 -27.743 1.00 47.81 ? 189 VAL B CG2 1 ATOM 4098 N N . TRP B 1 201 ? 77.196 97.177 -26.025 1.00 41.07 ? 190 TRP B N 1 ATOM 4099 C CA . TRP B 1 201 ? 77.648 97.719 -24.722 1.00 38.61 ? 190 TRP B CA 1 ATOM 4100 C C . TRP B 1 201 ? 78.722 96.798 -24.133 1.00 43.08 ? 190 TRP B C 1 ATOM 4101 O O . TRP B 1 201 ? 78.580 96.251 -23.036 1.00 42.19 ? 190 TRP B O 1 ATOM 4102 C CB . TRP B 1 201 ? 76.479 97.902 -23.759 1.00 34.80 ? 190 TRP B CB 1 ATOM 4103 C CG . TRP B 1 201 ? 75.496 98.948 -24.161 1.00 34.28 ? 190 TRP B CG 1 ATOM 4104 C CD1 . TRP B 1 201 ? 74.191 98.753 -24.519 1.00 36.69 ? 190 TRP B CD1 1 ATOM 4105 C CD2 . TRP B 1 201 ? 75.682 100.369 -24.076 1.00 34.02 ? 190 TRP B CD2 1 ATOM 4106 N NE1 . TRP B 1 201 ? 73.556 99.968 -24.685 1.00 35.62 ? 190 TRP B NE1 1 ATOM 4107 C CE2 . TRP B 1 201 ? 74.455 100.978 -24.432 1.00 36.76 ? 190 TRP B CE2 1 ATOM 4108 C CE3 . TRP B 1 201 ? 76.783 101.195 -23.771 1.00 35.18 ? 190 TRP B CE3 1 ATOM 4109 C CZ2 . TRP B 1 201 ? 74.299 102.363 -24.488 1.00 35.22 ? 190 TRP B CZ2 1 ATOM 4110 C CZ3 . TRP B 1 201 ? 76.622 102.569 -23.822 1.00 35.85 ? 190 TRP B CZ3 1 ATOM 4111 C CH2 . TRP B 1 201 ? 75.391 103.137 -24.167 1.00 36.44 ? 190 TRP B CH2 1 ATOM 4112 N N . GLN B 1 202 ? 79.790 96.611 -24.910 1.00 39.68 ? 191 GLN B N 1 ATOM 4113 C CA . GLN B 1 202 ? 80.912 95.732 -24.603 1.00 38.30 ? 191 GLN B CA 1 ATOM 4114 C C . GLN B 1 202 ? 82.183 96.562 -24.546 1.00 44.00 ? 191 GLN B C 1 ATOM 4115 O O . GLN B 1 202 ? 82.401 97.465 -25.360 1.00 42.91 ? 191 GLN B O 1 ATOM 4116 C CB . GLN B 1 202 ? 80.989 94.621 -25.656 1.00 37.59 ? 191 GLN B CB 1 ATOM 4117 C CG . GLN B 1 202 ? 81.954 93.517 -25.335 1.00 34.13 ? 191 GLN B CG 1 ATOM 4118 C CD . GLN B 1 202 ? 81.886 92.453 -26.399 1.00 59.20 ? 191 GLN B CD 1 ATOM 4119 O OE1 . GLN B 1 202 ? 82.060 92.716 -27.597 1.00 58.88 ? 191 GLN B OE1 1 ATOM 4120 N NE2 . GLN B 1 202 ? 81.622 91.219 -25.994 1.00 58.10 ? 191 GLN B NE2 1 ATOM 4121 N N . ILE B 1 203 ? 82.968 96.306 -23.504 1.00 42.49 ? 192 ILE B N 1 ATOM 4122 C CA . ILE B 1 203 ? 84.229 96.976 -23.186 1.00 40.96 ? 192 ILE B CA 1 ATOM 4123 C C . ILE B 1 203 ? 85.339 95.938 -23.049 1.00 44.38 ? 192 ILE B C 1 ATOM 4124 O O . ILE B 1 203 ? 85.072 94.730 -22.979 1.00 43.22 ? 192 ILE B O 1 ATOM 4125 C CB . ILE B 1 203 ? 84.093 97.879 -21.933 1.00 43.47 ? 192 ILE B CB 1 ATOM 4126 C CG1 . ILE B 1 203 ? 83.591 97.083 -20.698 1.00 44.18 ? 192 ILE B CG1 1 ATOM 4127 C CG2 . ILE B 1 203 ? 83.189 99.100 -22.215 1.00 43.39 ? 192 ILE B CG2 1 ATOM 4128 C CD1 . ILE B 1 203 ? 83.991 97.649 -19.324 1.00 43.06 ? 192 ILE B CD1 1 ATOM 4129 N N . GLN B 1 204 ? 86.584 96.408 -23.060 1.00 42.35 ? 193 GLN B N 1 ATOM 4130 C CA . GLN B 1 204 ? 87.772 95.563 -22.941 1.00 42.00 ? 193 GLN B CA 1 ATOM 4131 C C . GLN B 1 204 ? 88.085 95.362 -21.456 1.00 43.92 ? 193 GLN B C 1 ATOM 4132 O O . GLN B 1 204 ? 88.046 96.311 -20.666 1.00 40.28 ? 193 GLN B O 1 ATOM 4133 C CB . GLN B 1 204 ? 88.965 96.227 -23.682 1.00 43.60 ? 193 GLN B CB 1 ATOM 4134 C CG . GLN B 1 204 ? 90.294 95.448 -23.684 1.00 55.56 ? 193 GLN B CG 1 ATOM 4135 C CD . GLN B 1 204 ? 90.307 94.200 -24.559 1.00 85.96 ? 193 GLN B CD 1 ATOM 4136 O OE1 . GLN B 1 204 ? 89.820 94.176 -25.702 1.00 82.19 ? 193 GLN B OE1 1 ATOM 4137 N NE2 . GLN B 1 204 ? 90.930 93.145 -24.062 1.00 83.09 ? 193 GLN B NE2 1 ATOM 4138 N N . MET B 1 205 ? 88.366 94.110 -21.080 1.00 43.53 ? 194 MET B N 1 ATOM 4139 C CA . MET B 1 205 ? 88.758 93.728 -19.720 1.00 44.05 ? 194 MET B CA 1 ATOM 4140 C C . MET B 1 205 ? 90.240 93.330 -19.733 1.00 53.36 ? 194 MET B C 1 ATOM 4141 O O . MET B 1 205 ? 90.662 92.547 -20.589 1.00 55.75 ? 194 MET B O 1 ATOM 4142 C CB . MET B 1 205 ? 87.875 92.600 -19.204 1.00 46.08 ? 194 MET B CB 1 ATOM 4143 C CG . MET B 1 205 ? 88.088 92.315 -17.731 1.00 48.76 ? 194 MET B CG 1 ATOM 4144 S SD . MET B 1 205 ? 86.566 91.844 -16.892 1.00 50.69 ? 194 MET B SD 1 ATOM 4145 C CE . MET B 1 205 ? 86.238 90.306 -17.638 1.00 45.54 ? 194 MET B CE 1 ATOM 4146 N N . LYS B 1 206 ? 91.033 93.897 -18.830 1.00 52.64 ? 195 LYS B N 1 ATOM 4147 C CA . LYS B 1 206 ? 92.481 93.667 -18.804 1.00 54.51 ? 195 LYS B CA 1 ATOM 4148 C C . LYS B 1 206 ? 92.933 92.514 -17.890 1.00 59.66 ? 195 LYS B C 1 ATOM 4149 O O . LYS B 1 206 ? 94.099 92.132 -17.950 1.00 61.40 ? 195 LYS B O 1 ATOM 4150 C CB . LYS B 1 206 ? 93.236 94.965 -18.450 1.00 58.71 ? 195 LYS B CB 1 ATOM 4151 C CG . LYS B 1 206 ? 92.911 96.186 -19.338 1.00 81.04 ? 195 LYS B CG 1 ATOM 4152 C CD . LYS B 1 206 ? 93.222 97.513 -18.601 1.00 88.44 ? 195 LYS B CD 1 ATOM 4153 C CE . LYS B 1 206 ? 93.129 98.747 -19.457 1.00 94.04 ? 195 LYS B CE 1 ATOM 4154 N NZ . LYS B 1 206 ? 94.108 99.789 -19.031 1.00 100.59 ? 195 LYS B NZ 1 ATOM 4155 N N . GLY B 1 207 ? 92.028 91.962 -17.088 1.00 54.60 ? 196 GLY B N 1 ATOM 4156 C CA . GLY B 1 207 ? 92.338 90.871 -16.173 1.00 53.72 ? 196 GLY B CA 1 ATOM 4157 C C . GLY B 1 207 ? 91.304 90.659 -15.085 1.00 57.79 ? 196 GLY B C 1 ATOM 4158 O O . GLY B 1 207 ? 90.637 91.605 -14.656 1.00 57.04 ? 196 GLY B O 1 ATOM 4159 N N . VAL B 1 208 ? 91.149 89.389 -14.656 1.00 54.53 ? 197 VAL B N 1 ATOM 4160 C CA . VAL B 1 208 ? 90.233 88.943 -13.594 1.00 52.98 ? 197 VAL B CA 1 ATOM 4161 C C . VAL B 1 208 ? 91.114 88.334 -12.507 1.00 56.66 ? 197 VAL B C 1 ATOM 4162 O O . VAL B 1 208 ? 91.823 87.362 -12.766 1.00 56.95 ? 197 VAL B O 1 ATOM 4163 C CB . VAL B 1 208 ? 89.111 87.982 -14.084 1.00 55.15 ? 197 VAL B CB 1 ATOM 4164 C CG1 . VAL B 1 208 ? 88.181 87.600 -12.939 1.00 54.56 ? 197 VAL B CG1 1 ATOM 4165 C CG2 . VAL B 1 208 ? 88.305 88.602 -15.216 1.00 54.38 ? 197 VAL B CG2 1 ATOM 4166 N N . SER B 1 209 ? 91.142 88.968 -11.326 1.00 53.79 ? 198 SER B N 1 ATOM 4167 C CA . SER B 1 209 ? 91.976 88.571 -10.187 1.00 53.77 ? 198 SER B CA 1 ATOM 4168 C C . SER B 1 209 ? 91.235 87.857 -9.082 1.00 60.98 ? 198 SER B C 1 ATOM 4169 O O . SER B 1 209 ? 90.176 88.310 -8.640 1.00 59.49 ? 198 SER B O 1 ATOM 4170 C CB . SER B 1 209 ? 92.658 89.787 -9.575 1.00 56.25 ? 198 SER B CB 1 ATOM 4171 O OG . SER B 1 209 ? 93.625 90.357 -10.437 1.00 64.05 ? 198 SER B OG 1 ATOM 4172 N N . VAL B 1 210 ? 91.829 86.758 -8.598 1.00 61.87 ? 199 VAL B N 1 ATOM 4173 C CA . VAL B 1 210 ? 91.344 86.017 -7.445 1.00 63.05 ? 199 VAL B CA 1 ATOM 4174 C C . VAL B 1 210 ? 92.402 86.229 -6.354 1.00 72.71 ? 199 VAL B C 1 ATOM 4175 O O . VAL B 1 210 ? 93.515 85.716 -6.452 1.00 72.87 ? 199 VAL B O 1 ATOM 4176 C CB . VAL B 1 210 ? 91.006 84.533 -7.749 1.00 65.99 ? 199 VAL B CB 1 ATOM 4177 C CG1 . VAL B 1 210 ? 90.713 83.766 -6.469 1.00 65.66 ? 199 VAL B CG1 1 ATOM 4178 C CG2 . VAL B 1 210 ? 89.820 84.418 -8.702 1.00 65.67 ? 199 VAL B CG2 1 ATOM 4179 N N . GLY B 1 211 ? 92.064 87.061 -5.382 1.00 74.47 ? 200 GLY B N 1 ATOM 4180 C CA . GLY B 1 211 ? 92.955 87.404 -4.285 1.00 77.50 ? 200 GLY B CA 1 ATOM 4181 C C . GLY B 1 211 ? 93.743 88.662 -4.568 1.00 88.38 ? 200 GLY B C 1 ATOM 4182 O O . GLY B 1 211 ? 93.220 89.774 -4.435 1.00 89.16 ? 200 GLY B O 1 ATOM 4183 N N . SER B 1 212 ? 95.008 88.491 -4.982 1.00 88.29 ? 201 SER B N 1 ATOM 4184 C CA . SER B 1 212 ? 95.929 89.603 -5.288 1.00 89.11 ? 201 SER B CA 1 ATOM 4185 C C . SER B 1 212 ? 96.680 89.410 -6.624 1.00 93.36 ? 201 SER B C 1 ATOM 4186 O O . SER B 1 212 ? 97.493 90.264 -6.999 1.00 93.46 ? 201 SER B O 1 ATOM 4187 C CB . SER B 1 212 ? 96.934 89.780 -4.149 1.00 93.51 ? 201 SER B CB 1 ATOM 4188 O OG . SER B 1 212 ? 97.676 88.589 -3.929 1.00 105.54 ? 201 SER B OG 1 ATOM 4189 N N . SER B 1 213 ? 96.394 88.291 -7.331 1.00 89.06 ? 202 SER B N 1 ATOM 4190 C CA . SER B 1 213 ? 97.039 87.902 -8.585 1.00 88.35 ? 202 SER B CA 1 ATOM 4191 C C . SER B 1 213 ? 96.059 87.765 -9.759 1.00 90.49 ? 202 SER B C 1 ATOM 4192 O O . SER B 1 213 ? 95.018 87.118 -9.601 1.00 90.61 ? 202 SER B O 1 ATOM 4193 C CB . SER B 1 213 ? 97.815 86.598 -8.384 1.00 92.02 ? 202 SER B CB 1 ATOM 4194 O OG . SER B 1 213 ? 97.083 85.632 -7.645 1.00 100.13 ? 202 SER B OG 1 ATOM 4195 N N . THR B 1 214 ? 96.411 88.342 -10.948 1.00 85.07 ? 203 THR B N 1 ATOM 4196 C CA . THR B 1 214 ? 95.605 88.235 -12.176 1.00 84.17 ? 203 THR B CA 1 ATOM 4197 C C . THR B 1 214 ? 95.656 86.776 -12.654 1.00 85.47 ? 203 THR B C 1 ATOM 4198 O O . THR B 1 214 ? 96.541 86.378 -13.420 1.00 85.87 ? 203 THR B O 1 ATOM 4199 C CB . THR B 1 214 ? 95.966 89.314 -13.236 1.00 94.69 ? 203 THR B CB 1 ATOM 4200 O OG1 . THR B 1 214 ? 95.542 90.601 -12.769 1.00 96.81 ? 203 THR B OG1 1 ATOM 4201 C CG2 . THR B 1 214 ? 95.316 89.052 -14.606 1.00 92.62 ? 203 THR B CG2 1 ATOM 4202 N N . LEU B 1 215 ? 94.709 85.981 -12.138 1.00 78.11 ? 204 LEU B N 1 ATOM 4203 C CA . LEU B 1 215 ? 94.579 84.563 -12.391 1.00 75.82 ? 204 LEU B CA 1 ATOM 4204 C C . LEU B 1 215 ? 94.005 84.303 -13.791 1.00 73.53 ? 204 LEU B C 1 ATOM 4205 O O . LEU B 1 215 ? 94.435 83.360 -14.463 1.00 73.09 ? 204 LEU B O 1 ATOM 4206 C CB . LEU B 1 215 ? 93.670 83.980 -11.281 1.00 76.28 ? 204 LEU B CB 1 ATOM 4207 C CG . LEU B 1 215 ? 93.547 82.447 -11.170 1.00 80.82 ? 204 LEU B CG 1 ATOM 4208 C CD1 . LEU B 1 215 ? 93.612 81.987 -9.714 1.00 80.87 ? 204 LEU B CD1 1 ATOM 4209 C CD2 . LEU B 1 215 ? 92.257 81.957 -11.800 1.00 81.33 ? 204 LEU B CD2 1 ATOM 4210 N N . LEU B 1 216 ? 93.021 85.120 -14.214 1.00 65.57 ? 205 LEU B N 1 ATOM 4211 C CA . LEU B 1 216 ? 92.312 84.964 -15.491 1.00 63.64 ? 205 LEU B CA 1 ATOM 4212 C C . LEU B 1 216 ? 92.390 86.207 -16.356 1.00 64.89 ? 205 LEU B C 1 ATOM 4213 O O . LEU B 1 216 ? 92.693 87.291 -15.836 1.00 63.24 ? 205 LEU B O 1 ATOM 4214 C CB . LEU B 1 216 ? 90.818 84.658 -15.229 1.00 63.42 ? 205 LEU B CB 1 ATOM 4215 C CG . LEU B 1 216 ? 90.462 83.308 -14.621 1.00 67.90 ? 205 LEU B CG 1 ATOM 4216 C CD1 . LEU B 1 216 ? 89.069 83.321 -14.071 1.00 67.51 ? 205 LEU B CD1 1 ATOM 4217 C CD2 . LEU B 1 216 ? 90.586 82.198 -15.635 1.00 72.10 ? 205 LEU B CD2 1 ATOM 4218 N N . CYS B 1 217 ? 92.061 86.055 -17.679 1.00 60.95 ? 206 CYS B N 1 ATOM 4219 C CA . CYS B 1 217 ? 91.981 87.150 -18.656 1.00 61.59 ? 206 CYS B CA 1 ATOM 4220 C C . CYS B 1 217 ? 93.348 87.926 -18.722 1.00 68.98 ? 206 CYS B C 1 ATOM 4221 O O . CYS B 1 217 ? 93.384 89.155 -18.873 1.00 67.69 ? 206 CYS B O 1 ATOM 4222 C CB . CYS B 1 217 ? 90.802 88.057 -18.279 1.00 61.76 ? 206 CYS B CB 1 ATOM 4223 S SG . CYS B 1 217 ? 90.481 89.430 -19.419 1.00 65.54 ? 206 CYS B SG 1 ATOM 4224 N N . GLU B 1 218 ? 94.475 87.164 -18.584 1.00 68.13 ? 207 GLU B N 1 ATOM 4225 C CA . GLU B 1 218 ? 95.858 87.663 -18.540 1.00 68.55 ? 207 GLU B CA 1 ATOM 4226 C C . GLU B 1 218 ? 96.234 88.395 -19.812 1.00 72.91 ? 207 GLU B C 1 ATOM 4227 O O . GLU B 1 218 ? 96.844 89.464 -19.736 1.00 72.86 ? 207 GLU B O 1 ATOM 4228 C CB . GLU B 1 218 ? 96.868 86.524 -18.284 1.00 70.22 ? 207 GLU B CB 1 ATOM 4229 C CG . GLU B 1 218 ? 96.571 85.636 -17.087 1.00 84.86 ? 207 GLU B CG 1 ATOM 4230 C CD . GLU B 1 218 ? 96.048 84.245 -17.409 1.00 116.28 ? 207 GLU B CD 1 ATOM 4231 O OE1 . GLU B 1 218 ? 96.464 83.287 -16.715 1.00 118.15 ? 207 GLU B OE1 1 ATOM 4232 O OE2 . GLU B 1 218 ? 95.219 84.107 -18.341 1.00 109.48 ? 207 GLU B OE2 1 ATOM 4233 N N . ASP B 1 219 ? 95.855 87.831 -20.979 1.00 69.23 ? 208 ASP B N 1 ATOM 4234 C CA . ASP B 1 219 ? 96.170 88.426 -22.279 1.00 69.20 ? 208 ASP B CA 1 ATOM 4235 C C . ASP B 1 219 ? 95.044 89.312 -22.809 1.00 71.09 ? 208 ASP B C 1 ATOM 4236 O O . ASP B 1 219 ? 95.045 89.673 -23.991 1.00 71.81 ? 208 ASP B O 1 ATOM 4237 C CB . ASP B 1 219 ? 96.599 87.341 -23.304 1.00 71.45 ? 208 ASP B CB 1 ATOM 4238 C CG . ASP B 1 219 ? 97.837 86.542 -22.879 1.00 80.70 ? 208 ASP B CG 1 ATOM 4239 O OD1 . ASP B 1 219 ? 98.912 87.168 -22.655 1.00 78.11 ? 208 ASP B OD1 1 ATOM 4240 O OD2 . ASP B 1 219 ? 97.726 85.296 -22.751 1.00 88.00 ? 208 ASP B OD2 1 ATOM 4241 N N . GLY B 1 220 ? 94.120 89.675 -21.925 1.00 65.36 ? 209 GLY B N 1 ATOM 4242 C CA . GLY B 1 220 ? 92.974 90.521 -22.236 1.00 64.10 ? 209 GLY B CA 1 ATOM 4243 C C . GLY B 1 220 ? 91.766 89.744 -22.708 1.00 65.75 ? 209 GLY B C 1 ATOM 4244 O O . GLY B 1 220 ? 91.894 88.648 -23.265 1.00 65.75 ? 209 GLY B O 1 ATOM 4245 N N . CYS B 1 221 ? 90.574 90.306 -22.477 1.00 59.96 ? 210 CYS B N 1 ATOM 4246 C CA . CYS B 1 221 ? 89.311 89.693 -22.872 1.00 58.72 ? 210 CYS B CA 1 ATOM 4247 C C . CYS B 1 221 ? 88.203 90.722 -22.954 1.00 55.96 ? 210 CYS B C 1 ATOM 4248 O O . CYS B 1 221 ? 88.452 91.914 -22.779 1.00 54.81 ? 210 CYS B O 1 ATOM 4249 C CB . CYS B 1 221 ? 88.939 88.529 -21.954 1.00 60.13 ? 210 CYS B CB 1 ATOM 4250 S SG . CYS B 1 221 ? 88.660 89.002 -20.230 1.00 65.07 ? 210 CYS B SG 1 ATOM 4251 N N . LEU B 1 222 ? 86.989 90.253 -23.263 1.00 48.81 ? 211 LEU B N 1 ATOM 4252 C CA . LEU B 1 222 ? 85.804 91.086 -23.426 1.00 47.82 ? 211 LEU B CA 1 ATOM 4253 C C . LEU B 1 222 ? 84.883 91.006 -22.231 1.00 49.87 ? 211 LEU B C 1 ATOM 4254 O O . LEU B 1 222 ? 84.824 89.977 -21.535 1.00 46.39 ? 211 LEU B O 1 ATOM 4255 C CB . LEU B 1 222 ? 85.019 90.695 -24.689 1.00 47.63 ? 211 LEU B CB 1 ATOM 4256 C CG . LEU B 1 222 ? 85.789 90.621 -26.011 1.00 51.36 ? 211 LEU B CG 1 ATOM 4257 C CD1 . LEU B 1 222 ? 84.919 90.022 -27.096 1.00 50.26 ? 211 LEU B CD1 1 ATOM 4258 C CD2 . LEU B 1 222 ? 86.347 92.008 -26.411 1.00 51.97 ? 211 LEU B CD2 1 ATOM 4259 N N . ALA B 1 223 ? 84.148 92.117 -22.014 1.00 46.34 ? 212 ALA B N 1 ATOM 4260 C CA . ALA B 1 223 ? 83.158 92.278 -20.955 1.00 44.55 ? 212 ALA B CA 1 ATOM 4261 C C . ALA B 1 223 ? 81.919 92.981 -21.485 1.00 45.44 ? 212 ALA B C 1 ATOM 4262 O O . ALA B 1 223 ? 81.953 94.181 -21.776 1.00 43.15 ? 212 ALA B O 1 ATOM 4263 C CB . ALA B 1 223 ? 83.754 93.050 -19.787 1.00 44.93 ? 212 ALA B CB 1 ATOM 4264 N N . LEU B 1 224 ? 80.830 92.216 -21.656 1.00 42.11 ? 213 LEU B N 1 ATOM 4265 C CA . LEU B 1 224 ? 79.526 92.768 -22.037 1.00 41.32 ? 213 LEU B CA 1 ATOM 4266 C C . LEU B 1 224 ? 78.870 93.252 -20.722 1.00 43.00 ? 213 LEU B C 1 ATOM 4267 O O . LEU B 1 224 ? 78.837 92.501 -19.752 1.00 40.45 ? 213 LEU B O 1 ATOM 4268 C CB . LEU B 1 224 ? 78.666 91.700 -22.737 1.00 41.22 ? 213 LEU B CB 1 ATOM 4269 C CG . LEU B 1 224 ? 77.215 92.115 -23.106 1.00 46.87 ? 213 LEU B CG 1 ATOM 4270 C CD1 . LEU B 1 224 ? 77.161 93.143 -24.273 1.00 45.60 ? 213 LEU B CD1 1 ATOM 4271 C CD2 . LEU B 1 224 ? 76.346 90.887 -23.408 1.00 48.46 ? 213 LEU B CD2 1 ATOM 4272 N N . VAL B 1 225 ? 78.467 94.528 -20.656 1.00 40.52 ? 214 VAL B N 1 ATOM 4273 C CA . VAL B 1 225 ? 77.815 95.117 -19.463 1.00 39.73 ? 214 VAL B CA 1 ATOM 4274 C C . VAL B 1 225 ? 76.306 95.007 -19.700 1.00 44.20 ? 214 VAL B C 1 ATOM 4275 O O . VAL B 1 225 ? 75.708 95.806 -20.426 1.00 44.85 ? 214 VAL B O 1 ATOM 4276 C CB . VAL B 1 225 ? 78.340 96.537 -19.086 1.00 42.23 ? 214 VAL B CB 1 ATOM 4277 C CG1 . VAL B 1 225 ? 77.809 96.980 -17.721 1.00 41.82 ? 214 VAL B CG1 1 ATOM 4278 C CG2 . VAL B 1 225 ? 79.869 96.556 -19.079 1.00 41.26 ? 214 VAL B CG2 1 ATOM 4279 N N . ASP B 1 226 ? 75.734 93.919 -19.176 1.00 40.57 ? 215 ASP B N 1 ATOM 4280 C CA . ASP B 1 226 ? 74.372 93.456 -19.427 1.00 40.76 ? 215 ASP B CA 1 ATOM 4281 C C . ASP B 1 226 ? 73.390 93.556 -18.244 1.00 47.04 ? 215 ASP B C 1 ATOM 4282 O O . ASP B 1 226 ? 73.351 92.682 -17.366 1.00 47.88 ? 215 ASP B O 1 ATOM 4283 C CB . ASP B 1 226 ? 74.473 91.988 -19.915 1.00 42.34 ? 215 ASP B CB 1 ATOM 4284 C CG . ASP B 1 226 ? 73.233 91.393 -20.555 1.00 49.42 ? 215 ASP B CG 1 ATOM 4285 O OD1 . ASP B 1 226 ? 72.208 92.104 -20.654 1.00 48.62 ? 215 ASP B OD1 1 ATOM 4286 O OD2 . ASP B 1 226 ? 73.291 90.224 -20.968 1.00 57.36 ? 215 ASP B OD2 1 ATOM 4287 N N . THR B 1 227 ? 72.525 94.565 -18.290 1.00 42.63 ? 216 THR B N 1 ATOM 4288 C CA . THR B 1 227 ? 71.511 94.802 -17.266 1.00 42.00 ? 216 THR B CA 1 ATOM 4289 C C . THR B 1 227 ? 70.436 93.695 -17.206 1.00 46.08 ? 216 THR B C 1 ATOM 4290 O O . THR B 1 227 ? 69.829 93.490 -16.147 1.00 46.97 ? 216 THR B O 1 ATOM 4291 C CB . THR B 1 227 ? 70.869 96.176 -17.481 1.00 44.88 ? 216 THR B CB 1 ATOM 4292 O OG1 . THR B 1 227 ? 70.258 96.185 -18.770 1.00 42.11 ? 216 THR B OG1 1 ATOM 4293 C CG2 . THR B 1 227 ? 71.868 97.323 -17.365 1.00 41.66 ? 216 THR B CG2 1 ATOM 4294 N N . GLY B 1 228 ? 70.203 93.013 -18.327 1.00 39.78 ? 217 GLY B N 1 ATOM 4295 C CA . GLY B 1 228 ? 69.205 91.945 -18.430 1.00 37.84 ? 217 GLY B CA 1 ATOM 4296 C C . GLY B 1 228 ? 69.679 90.555 -18.007 1.00 39.23 ? 217 GLY B C 1 ATOM 4297 O O . GLY B 1 228 ? 68.929 89.581 -18.119 1.00 38.58 ? 217 GLY B O 1 ATOM 4298 N N . ALA B 1 229 ? 70.948 90.444 -17.550 1.00 34.29 ? 218 ALA B N 1 ATOM 4299 C CA . ALA B 1 229 ? 71.561 89.206 -17.064 1.00 32.92 ? 218 ALA B CA 1 ATOM 4300 C C . ALA B 1 229 ? 71.588 89.237 -15.538 1.00 38.15 ? 218 ALA B C 1 ATOM 4301 O O . ALA B 1 229 ? 71.815 90.288 -14.931 1.00 40.64 ? 218 ALA B O 1 ATOM 4302 C CB . ALA B 1 229 ? 72.973 89.083 -17.595 1.00 33.27 ? 218 ALA B CB 1 ATOM 4303 N N . SER B 1 230 ? 71.363 88.091 -14.923 1.00 33.56 ? 219 SER B N 1 ATOM 4304 C CA . SER B 1 230 ? 71.304 87.945 -13.482 1.00 33.84 ? 219 SER B CA 1 ATOM 4305 C C . SER B 1 230 ? 72.675 87.937 -12.841 1.00 41.04 ? 219 SER B C 1 ATOM 4306 O O . SER B 1 230 ? 72.858 88.472 -11.758 1.00 41.75 ? 219 SER B O 1 ATOM 4307 C CB . SER B 1 230 ? 70.575 86.642 -13.126 1.00 37.10 ? 219 SER B CB 1 ATOM 4308 O OG . SER B 1 230 ? 69.252 86.595 -13.644 1.00 46.60 ? 219 SER B OG 1 ATOM 4309 N N . TYR B 1 231 ? 73.621 87.281 -13.482 1.00 39.30 ? 220 TYR B N 1 ATOM 4310 C CA . TYR B 1 231 ? 74.938 87.058 -12.917 1.00 39.03 ? 220 TYR B CA 1 ATOM 4311 C C . TYR B 1 231 ? 76.093 87.695 -13.648 1.00 45.02 ? 220 TYR B C 1 ATOM 4312 O O . TYR B 1 231 ? 75.930 88.403 -14.633 1.00 45.55 ? 220 TYR B O 1 ATOM 4313 C CB . TYR B 1 231 ? 75.169 85.527 -12.825 1.00 39.54 ? 220 TYR B CB 1 ATOM 4314 C CG . TYR B 1 231 ? 73.991 84.786 -12.247 1.00 41.34 ? 220 TYR B CG 1 ATOM 4315 C CD1 . TYR B 1 231 ? 73.557 85.039 -10.944 1.00 43.21 ? 220 TYR B CD1 1 ATOM 4316 C CD2 . TYR B 1 231 ? 73.277 83.866 -13.012 1.00 41.67 ? 220 TYR B CD2 1 ATOM 4317 C CE1 . TYR B 1 231 ? 72.474 84.363 -10.400 1.00 42.67 ? 220 TYR B CE1 1 ATOM 4318 C CE2 . TYR B 1 231 ? 72.164 83.212 -12.493 1.00 42.96 ? 220 TYR B CE2 1 ATOM 4319 C CZ . TYR B 1 231 ? 71.781 83.451 -11.178 1.00 53.37 ? 220 TYR B CZ 1 ATOM 4320 O OH . TYR B 1 231 ? 70.693 82.811 -10.649 1.00 59.24 ? 220 TYR B OH 1 ATOM 4321 N N . ILE B 1 232 ? 77.275 87.460 -13.115 1.00 43.21 ? 221 ILE B N 1 ATOM 4322 C CA . ILE B 1 232 ? 78.539 87.757 -13.724 1.00 43.74 ? 221 ILE B CA 1 ATOM 4323 C C . ILE B 1 232 ? 78.805 86.383 -14.346 1.00 51.09 ? 221 ILE B C 1 ATOM 4324 O O . ILE B 1 232 ? 78.710 85.353 -13.660 1.00 50.98 ? 221 ILE B O 1 ATOM 4325 C CB . ILE B 1 232 ? 79.654 88.152 -12.726 1.00 46.48 ? 221 ILE B CB 1 ATOM 4326 C CG1 . ILE B 1 232 ? 79.450 89.578 -12.235 1.00 45.81 ? 221 ILE B CG1 1 ATOM 4327 C CG2 . ILE B 1 232 ? 81.044 87.992 -13.369 1.00 47.14 ? 221 ILE B CG2 1 ATOM 4328 C CD1 . ILE B 1 232 ? 80.282 89.941 -11.029 1.00 42.45 ? 221 ILE B CD1 1 ATOM 4329 N N . SER B 1 233 ? 79.033 86.367 -15.661 1.00 47.57 ? 222 SER B N 1 ATOM 4330 C CA . SER B 1 233 ? 79.272 85.142 -16.365 1.00 45.58 ? 222 SER B CA 1 ATOM 4331 C C . SER B 1 233 ? 80.528 85.225 -17.211 1.00 49.08 ? 222 SER B C 1 ATOM 4332 O O . SER B 1 233 ? 80.951 86.296 -17.627 1.00 46.98 ? 222 SER B O 1 ATOM 4333 C CB . SER B 1 233 ? 78.050 84.788 -17.206 1.00 47.28 ? 222 SER B CB 1 ATOM 4334 O OG . SER B 1 233 ? 77.963 85.565 -18.387 1.00 58.02 ? 222 SER B OG 1 ATOM 4335 N N . GLY B 1 234 ? 81.123 84.075 -17.415 1.00 47.93 ? 223 GLY B N 1 ATOM 4336 C CA . GLY B 1 234 ? 82.273 83.891 -18.272 1.00 48.24 ? 223 GLY B CA 1 ATOM 4337 C C . GLY B 1 234 ? 82.076 82.578 -18.980 1.00 55.03 ? 223 GLY B C 1 ATOM 4338 O O . GLY B 1 234 ? 81.119 81.849 -18.685 1.00 55.30 ? 223 GLY B O 1 ATOM 4339 N N . SER B 1 235 ? 82.982 82.262 -19.914 1.00 53.06 ? 224 SER B N 1 ATOM 4340 C CA . SER B 1 235 ? 83.002 80.993 -20.653 1.00 51.57 ? 224 SER B CA 1 ATOM 4341 C C . SER B 1 235 ? 83.134 79.823 -19.649 1.00 55.55 ? 224 SER B C 1 ATOM 4342 O O . SER B 1 235 ? 83.776 79.985 -18.594 1.00 54.93 ? 224 SER B O 1 ATOM 4343 C CB . SER B 1 235 ? 84.207 80.965 -21.590 1.00 51.58 ? 224 SER B CB 1 ATOM 4344 O OG . SER B 1 235 ? 85.416 80.842 -20.852 1.00 58.65 ? 224 SER B OG 1 ATOM 4345 N N . THR B 1 236 ? 82.573 78.648 -20.008 1.00 51.69 ? 225 THR B N 1 ATOM 4346 C CA . THR B 1 236 ? 82.656 77.402 -19.246 1.00 51.02 ? 225 THR B CA 1 ATOM 4347 C C . THR B 1 236 ? 84.090 77.176 -18.746 1.00 57.11 ? 225 THR B C 1 ATOM 4348 O O . THR B 1 236 ? 84.284 76.855 -17.573 1.00 58.26 ? 225 THR B O 1 ATOM 4349 C CB . THR B 1 236 ? 82.123 76.258 -20.102 1.00 58.34 ? 225 THR B CB 1 ATOM 4350 O OG1 . THR B 1 236 ? 80.736 76.480 -20.348 1.00 58.08 ? 225 THR B OG1 1 ATOM 4351 C CG2 . THR B 1 236 ? 82.290 74.901 -19.457 1.00 57.20 ? 225 THR B CG2 1 ATOM 4352 N N . SER B 1 237 ? 85.084 77.434 -19.604 1.00 55.13 ? 226 SER B N 1 ATOM 4353 C CA . SER B 1 237 ? 86.505 77.288 -19.290 1.00 55.61 ? 226 SER B CA 1 ATOM 4354 C C . SER B 1 237 ? 86.953 78.234 -18.178 1.00 58.92 ? 226 SER B C 1 ATOM 4355 O O . SER B 1 237 ? 87.524 77.774 -17.186 1.00 59.63 ? 226 SER B O 1 ATOM 4356 C CB . SER B 1 237 ? 87.354 77.496 -20.541 1.00 61.39 ? 226 SER B CB 1 ATOM 4357 O OG . SER B 1 237 ? 88.728 77.305 -20.238 1.00 74.87 ? 226 SER B OG 1 ATOM 4358 N N . SER B 1 238 ? 86.687 79.545 -18.339 1.00 53.97 ? 227 SER B N 1 ATOM 4359 C CA . SER B 1 238 ? 87.053 80.581 -17.372 1.00 53.52 ? 227 SER B CA 1 ATOM 4360 C C . SER B 1 238 ? 86.437 80.338 -15.988 1.00 55.79 ? 227 SER B C 1 ATOM 4361 O O . SER B 1 238 ? 87.158 80.367 -14.979 1.00 56.09 ? 227 SER B O 1 ATOM 4362 C CB . SER B 1 238 ? 86.665 81.961 -17.895 1.00 57.61 ? 227 SER B CB 1 ATOM 4363 O OG . SER B 1 238 ? 87.361 82.273 -19.092 1.00 64.18 ? 227 SER B OG 1 ATOM 4364 N N . ILE B 1 239 ? 85.120 80.049 -15.955 1.00 49.03 ? 228 ILE B N 1 ATOM 4365 C CA . ILE B 1 239 ? 84.379 79.769 -14.733 1.00 48.24 ? 228 ILE B CA 1 ATOM 4366 C C . ILE B 1 239 ? 84.944 78.515 -14.034 1.00 55.36 ? 228 ILE B C 1 ATOM 4367 O O . ILE B 1 239 ? 85.089 78.535 -12.810 1.00 55.24 ? 228 ILE B O 1 ATOM 4368 C CB . ILE B 1 239 ? 82.849 79.742 -15.011 1.00 50.72 ? 228 ILE B CB 1 ATOM 4369 C CG1 . ILE B 1 239 ? 82.355 81.142 -15.547 1.00 51.15 ? 228 ILE B CG1 1 ATOM 4370 C CG2 . ILE B 1 239 ? 82.022 79.264 -13.793 1.00 50.96 ? 228 ILE B CG2 1 ATOM 4371 C CD1 . ILE B 1 239 ? 82.899 82.521 -14.779 1.00 45.41 ? 228 ILE B CD1 1 ATOM 4372 N N . GLU B 1 240 ? 85.369 77.485 -14.809 1.00 53.60 ? 229 GLU B N 1 ATOM 4373 C CA . GLU B 1 240 ? 85.987 76.282 -14.253 1.00 53.93 ? 229 GLU B CA 1 ATOM 4374 C C . GLU B 1 240 ? 87.281 76.636 -13.505 1.00 58.20 ? 229 GLU B C 1 ATOM 4375 O O . GLU B 1 240 ? 87.457 76.226 -12.351 1.00 56.80 ? 229 GLU B O 1 ATOM 4376 C CB . GLU B 1 240 ? 86.277 75.267 -15.351 1.00 55.57 ? 229 GLU B CB 1 ATOM 4377 C CG . GLU B 1 240 ? 85.108 74.349 -15.648 1.00 70.11 ? 229 GLU B CG 1 ATOM 4378 C CD . GLU B 1 240 ? 85.240 73.463 -16.878 1.00 96.16 ? 229 GLU B CD 1 ATOM 4379 O OE1 . GLU B 1 240 ? 84.220 72.837 -17.255 1.00 90.30 ? 229 GLU B OE1 1 ATOM 4380 O OE2 . GLU B 1 240 ? 86.352 73.385 -17.458 1.00 82.12 ? 229 GLU B OE2 1 ATOM 4381 N N . LYS B 1 241 ? 88.155 77.444 -14.141 1.00 55.73 ? 230 LYS B N 1 ATOM 4382 C CA . LYS B 1 241 ? 89.413 77.863 -13.511 1.00 56.20 ? 230 LYS B CA 1 ATOM 4383 C C . LYS B 1 241 ? 89.094 78.657 -12.253 1.00 59.10 ? 230 LYS B C 1 ATOM 4384 O O . LYS B 1 241 ? 89.561 78.281 -11.180 1.00 59.44 ? 230 LYS B O 1 ATOM 4385 C CB . LYS B 1 241 ? 90.317 78.670 -14.472 1.00 58.88 ? 230 LYS B CB 1 ATOM 4386 C CG . LYS B 1 241 ? 90.655 77.949 -15.782 1.00 74.35 ? 230 LYS B CG 1 ATOM 4387 C CD . LYS B 1 241 ? 91.661 78.738 -16.638 1.00 84.75 ? 230 LYS B CD 1 ATOM 4388 C CE . LYS B 1 241 ? 91.342 78.704 -18.124 1.00 88.13 ? 230 LYS B CE 1 ATOM 4389 N NZ . LYS B 1 241 ? 91.586 80.023 -18.784 1.00 88.22 ? 230 LYS B NZ 1 ATOM 4390 N N . LEU B 1 242 ? 88.203 79.675 -12.379 1.00 53.26 ? 231 LEU B N 1 ATOM 4391 C CA . LEU B 1 242 ? 87.741 80.555 -11.307 1.00 51.50 ? 231 LEU B CA 1 ATOM 4392 C C . LEU B 1 242 ? 87.266 79.785 -10.093 1.00 52.73 ? 231 LEU B C 1 ATOM 4393 O O . LEU B 1 242 ? 87.707 80.072 -8.977 1.00 51.51 ? 231 LEU B O 1 ATOM 4394 C CB . LEU B 1 242 ? 86.616 81.469 -11.822 1.00 51.54 ? 231 LEU B CB 1 ATOM 4395 C CG . LEU B 1 242 ? 86.055 82.495 -10.832 1.00 56.21 ? 231 LEU B CG 1 ATOM 4396 C CD1 . LEU B 1 242 ? 86.818 83.799 -10.900 1.00 57.17 ? 231 LEU B CD1 1 ATOM 4397 C CD2 . LEU B 1 242 ? 84.619 82.749 -11.096 1.00 55.69 ? 231 LEU B CD2 1 ATOM 4398 N N . MET B 1 243 ? 86.366 78.812 -10.304 1.00 48.48 ? 232 MET B N 1 ATOM 4399 C CA . MET B 1 243 ? 85.783 78.023 -9.209 1.00 47.47 ? 232 MET B CA 1 ATOM 4400 C C . MET B 1 243 ? 86.795 77.140 -8.510 1.00 54.03 ? 232 MET B C 1 ATOM 4401 O O . MET B 1 243 ? 86.812 77.072 -7.284 1.00 53.36 ? 232 MET B O 1 ATOM 4402 C CB . MET B 1 243 ? 84.570 77.221 -9.692 1.00 48.74 ? 232 MET B CB 1 ATOM 4403 C CG . MET B 1 243 ? 83.434 78.086 -10.162 1.00 51.67 ? 232 MET B CG 1 ATOM 4404 S SD . MET B 1 243 ? 82.694 79.077 -8.867 1.00 55.36 ? 232 MET B SD 1 ATOM 4405 C CE . MET B 1 243 ? 81.859 80.265 -9.868 1.00 52.37 ? 232 MET B CE 1 ATOM 4406 N N . GLU B 1 244 ? 87.662 76.499 -9.299 1.00 53.63 ? 233 GLU B N 1 ATOM 4407 C CA . GLU B 1 244 ? 88.736 75.648 -8.817 1.00 54.41 ? 233 GLU B CA 1 ATOM 4408 C C . GLU B 1 244 ? 89.598 76.467 -7.858 1.00 57.92 ? 233 GLU B C 1 ATOM 4409 O O . GLU B 1 244 ? 89.922 75.991 -6.777 1.00 58.76 ? 233 GLU B O 1 ATOM 4410 C CB . GLU B 1 244 ? 89.515 75.083 -10.022 1.00 56.22 ? 233 GLU B CB 1 ATOM 4411 C CG . GLU B 1 244 ? 91.008 74.901 -9.868 1.00 74.93 ? 233 GLU B CG 1 ATOM 4412 C CD . GLU B 1 244 ? 91.450 73.570 -9.293 1.00 112.91 ? 233 GLU B CD 1 ATOM 4413 O OE1 . GLU B 1 244 ? 91.726 72.642 -10.087 1.00 118.34 ? 233 GLU B OE1 1 ATOM 4414 O OE2 . GLU B 1 244 ? 91.545 73.465 -8.047 1.00 110.75 ? 233 GLU B OE2 1 ATOM 4415 N N . ALA B 1 245 ? 89.864 77.729 -8.213 1.00 54.25 ? 234 ALA B N 1 ATOM 4416 C CA . ALA B 1 245 ? 90.622 78.676 -7.391 1.00 53.87 ? 234 ALA B CA 1 ATOM 4417 C C . ALA B 1 245 ? 89.856 79.051 -6.111 1.00 60.56 ? 234 ALA B C 1 ATOM 4418 O O . ALA B 1 245 ? 90.485 79.272 -5.073 1.00 60.65 ? 234 ALA B O 1 ATOM 4419 C CB . ALA B 1 245 ? 90.931 79.930 -8.194 1.00 53.98 ? 234 ALA B CB 1 ATOM 4420 N N . LEU B 1 246 ? 88.501 79.132 -6.185 1.00 57.27 ? 235 LEU B N 1 ATOM 4421 C CA . LEU B 1 246 ? 87.666 79.488 -5.038 1.00 56.32 ? 235 LEU B CA 1 ATOM 4422 C C . LEU B 1 246 ? 87.470 78.351 -4.040 1.00 61.52 ? 235 LEU B C 1 ATOM 4423 O O . LEU B 1 246 ? 87.283 78.612 -2.844 1.00 61.87 ? 235 LEU B O 1 ATOM 4424 C CB . LEU B 1 246 ? 86.312 80.051 -5.485 1.00 55.87 ? 235 LEU B CB 1 ATOM 4425 C CG . LEU B 1 246 ? 86.349 81.367 -6.247 1.00 59.45 ? 235 LEU B CG 1 ATOM 4426 C CD1 . LEU B 1 246 ? 84.949 81.759 -6.690 1.00 58.68 ? 235 LEU B CD1 1 ATOM 4427 C CD2 . LEU B 1 246 ? 87.047 82.486 -5.432 1.00 59.08 ? 235 LEU B CD2 1 ATOM 4428 N N . GLY B 1 247 ? 87.529 77.111 -4.524 1.00 56.67 ? 236 GLY B N 1 ATOM 4429 C CA . GLY B 1 247 ? 87.305 75.933 -3.701 1.00 55.40 ? 236 GLY B CA 1 ATOM 4430 C C . GLY B 1 247 ? 85.846 75.537 -3.754 1.00 58.71 ? 236 GLY B C 1 ATOM 4431 O O . GLY B 1 247 ? 85.388 74.719 -2.945 1.00 59.01 ? 236 GLY B O 1 ATOM 4432 N N . ALA B 1 248 ? 85.116 76.103 -4.748 1.00 53.85 ? 237 ALA B N 1 ATOM 4433 C CA . ALA B 1 248 ? 83.715 75.830 -5.043 1.00 52.98 ? 237 ALA B CA 1 ATOM 4434 C C . ALA B 1 248 ? 83.586 74.574 -5.923 1.00 58.68 ? 237 ALA B C 1 ATOM 4435 O O . ALA B 1 248 ? 84.395 74.364 -6.838 1.00 59.37 ? 237 ALA B O 1 ATOM 4436 C CB . ALA B 1 248 ? 83.100 77.023 -5.753 1.00 53.28 ? 237 ALA B CB 1 ATOM 4437 N N . LYS B 1 249 ? 82.575 73.740 -5.648 1.00 54.56 ? 238 LYS B N 1 ATOM 4438 C CA . LYS B 1 249 ? 82.325 72.518 -6.419 1.00 54.08 ? 238 LYS B CA 1 ATOM 4439 C C . LYS B 1 249 ? 81.013 72.649 -7.155 1.00 58.20 ? 238 LYS B C 1 ATOM 4440 O O . LYS B 1 249 ? 80.114 73.360 -6.696 1.00 57.49 ? 238 LYS B O 1 ATOM 4441 C CB . LYS B 1 249 ? 82.244 71.276 -5.508 1.00 56.21 ? 238 LYS B CB 1 ATOM 4442 C CG . LYS B 1 249 ? 83.317 71.162 -4.432 1.00 61.23 ? 238 LYS B CG 1 ATOM 4443 C CD . LYS B 1 249 ? 84.570 70.456 -4.869 1.00 75.15 ? 238 LYS B CD 1 ATOM 4444 C CE . LYS B 1 249 ? 85.615 70.484 -3.766 1.00 96.82 ? 238 LYS B CE 1 ATOM 4445 N NZ . LYS B 1 249 ? 85.227 69.673 -2.575 1.00 109.47 ? 238 LYS B NZ 1 ATOM 4446 N N . LYS B 1 250 ? 80.843 71.889 -8.230 1.00 55.97 ? 239 LYS B N 1 ATOM 4447 C CA . LYS B 1 250 ? 79.555 71.868 -8.918 1.00 56.70 ? 239 LYS B CA 1 ATOM 4448 C C . LYS B 1 250 ? 78.711 70.828 -8.175 1.00 65.34 ? 239 LYS B C 1 ATOM 4449 O O . LYS B 1 250 ? 79.160 69.678 -8.088 1.00 66.56 ? 239 LYS B O 1 ATOM 4450 C CB . LYS B 1 250 ? 79.721 71.494 -10.408 1.00 57.41 ? 239 LYS B CB 1 ATOM 4451 C CG . LYS B 1 250 ? 78.435 71.591 -11.233 1.00 67.72 ? 239 LYS B CG 1 ATOM 4452 C CD . LYS B 1 250 ? 78.200 72.952 -11.872 1.00 78.09 ? 239 LYS B CD 1 ATOM 4453 C CE . LYS B 1 250 ? 78.651 73.002 -13.321 1.00 99.83 ? 239 LYS B CE 1 ATOM 4454 N NZ . LYS B 1 250 ? 78.231 74.256 -14.028 1.00 108.84 ? 239 LYS B NZ 1 ATOM 4455 N N . ARG B 1 251 ? 77.525 71.208 -7.599 1.00 63.20 ? 240 ARG B N 1 ATOM 4456 C CA . ARG B 1 251 ? 76.732 70.172 -6.936 1.00 63.71 ? 240 ARG B CA 1 ATOM 4457 C C . ARG B 1 251 ? 76.075 69.311 -7.996 1.00 67.23 ? 240 ARG B C 1 ATOM 4458 O O . ARG B 1 251 ? 76.638 68.266 -8.356 1.00 65.95 ? 240 ARG B O 1 ATOM 4459 C CB . ARG B 1 251 ? 75.773 70.640 -5.803 1.00 65.72 ? 240 ARG B CB 1 ATOM 4460 C CG . ARG B 1 251 ? 74.767 71.754 -6.031 1.00 75.12 ? 240 ARG B CG 1 ATOM 4461 C CD . ARG B 1 251 ? 73.824 71.836 -4.816 1.00 76.52 ? 240 ARG B CD 1 ATOM 4462 N NE . ARG B 1 251 ? 72.890 72.969 -4.887 1.00 76.93 ? 240 ARG B NE 1 ATOM 4463 C CZ . ARG B 1 251 ? 72.492 73.694 -3.841 1.00 72.69 ? 240 ARG B CZ 1 ATOM 4464 N NH1 . ARG B 1 251 ? 72.928 73.415 -2.627 1.00 48.33 ? 240 ARG B NH1 1 ATOM 4465 N NH2 . ARG B 1 251 ? 71.663 74.710 -4.010 1.00 58.06 ? 240 ARG B NH2 1 ATOM 4466 N N . LEU B 1 252 ? 74.971 69.782 -8.575 1.00 64.96 ? 241 LEU B N 1 ATOM 4467 C CA . LEU B 1 252 ? 74.309 69.049 -9.651 1.00 65.13 ? 241 LEU B CA 1 ATOM 4468 C C . LEU B 1 252 ? 74.053 69.962 -10.800 1.00 69.22 ? 241 LEU B C 1 ATOM 4469 O O . LEU B 1 252 ? 74.149 69.539 -11.944 1.00 70.93 ? 241 LEU B O 1 ATOM 4470 C CB . LEU B 1 252 ? 72.999 68.399 -9.193 1.00 65.13 ? 241 LEU B CB 1 ATOM 4471 C CG . LEU B 1 252 ? 73.113 67.454 -8.006 1.00 69.37 ? 241 LEU B CG 1 ATOM 4472 C CD1 . LEU B 1 252 ? 71.911 67.557 -7.175 1.00 70.36 ? 241 LEU B CD1 1 ATOM 4473 C CD2 . LEU B 1 252 ? 73.379 66.017 -8.433 1.00 69.46 ? 241 LEU B CD2 1 ATOM 4474 N N . PHE B 1 253 ? 73.736 71.217 -10.504 1.00 63.57 ? 242 PHE B N 1 ATOM 4475 C CA . PHE B 1 253 ? 73.452 72.197 -11.528 1.00 62.17 ? 242 PHE B CA 1 ATOM 4476 C C . PHE B 1 253 ? 74.334 73.407 -11.344 1.00 67.78 ? 242 PHE B C 1 ATOM 4477 O O . PHE B 1 253 ? 74.771 73.983 -12.337 1.00 69.09 ? 242 PHE B O 1 ATOM 4478 C CB . PHE B 1 253 ? 71.970 72.620 -11.477 1.00 63.43 ? 242 PHE B CB 1 ATOM 4479 C CG . PHE B 1 253 ? 70.949 71.502 -11.475 1.00 64.33 ? 242 PHE B CG 1 ATOM 4480 C CD1 . PHE B 1 253 ? 70.501 70.941 -12.671 1.00 66.97 ? 242 PHE B CD1 1 ATOM 4481 C CD2 . PHE B 1 253 ? 70.410 71.033 -10.283 1.00 65.25 ? 242 PHE B CD2 1 ATOM 4482 C CE1 . PHE B 1 253 ? 69.547 69.914 -12.670 1.00 67.65 ? 242 PHE B CE1 1 ATOM 4483 C CE2 . PHE B 1 253 ? 69.458 70.005 -10.280 1.00 68.09 ? 242 PHE B CE2 1 ATOM 4484 C CZ . PHE B 1 253 ? 69.020 69.462 -11.473 1.00 66.60 ? 242 PHE B CZ 1 ATOM 4485 N N . ASP B 1 254 ? 74.586 73.831 -10.088 1.00 63.98 ? 244 ASP B N 1 ATOM 4486 C CA . ASP B 1 254 ? 75.338 75.060 -9.872 1.00 62.86 ? 244 ASP B CA 1 ATOM 4487 C C . ASP B 1 254 ? 76.533 74.918 -8.935 1.00 63.98 ? 244 ASP B C 1 ATOM 4488 O O . ASP B 1 254 ? 76.750 73.851 -8.354 1.00 64.45 ? 244 ASP B O 1 ATOM 4489 C CB . ASP B 1 254 ? 74.379 76.166 -9.420 1.00 64.84 ? 244 ASP B CB 1 ATOM 4490 C CG . ASP B 1 254 ? 73.413 76.556 -10.529 1.00 74.75 ? 244 ASP B CG 1 ATOM 4491 O OD1 . ASP B 1 254 ? 73.879 77.069 -11.571 1.00 76.44 ? 244 ASP B OD1 1 ATOM 4492 O OD2 . ASP B 1 254 ? 72.221 76.237 -10.411 1.00 78.79 ? 244 ASP B OD2 1 ATOM 4493 N N . TYR B 1 255 ? 77.343 75.985 -8.842 1.00 56.30 ? 245 TYR B N 1 ATOM 4494 C CA . TYR B 1 255 ? 78.551 75.948 -8.030 1.00 54.36 ? 245 TYR B CA 1 ATOM 4495 C C . TYR B 1 255 ? 78.246 76.384 -6.620 1.00 56.55 ? 245 TYR B C 1 ATOM 4496 O O . TYR B 1 255 ? 77.592 77.425 -6.424 1.00 58.41 ? 245 TYR B O 1 ATOM 4497 C CB . TYR B 1 255 ? 79.661 76.822 -8.614 1.00 55.10 ? 245 TYR B CB 1 ATOM 4498 C CG . TYR B 1 255 ? 80.359 76.242 -9.816 1.00 55.66 ? 245 TYR B CG 1 ATOM 4499 C CD1 . TYR B 1 255 ? 81.422 75.355 -9.667 1.00 57.52 ? 245 TYR B CD1 1 ATOM 4500 C CD2 . TYR B 1 255 ? 80.004 76.632 -11.104 1.00 55.79 ? 245 TYR B CD2 1 ATOM 4501 C CE1 . TYR B 1 255 ? 82.110 74.869 -10.773 1.00 58.01 ? 245 TYR B CE1 1 ATOM 4502 C CE2 . TYR B 1 255 ? 80.693 76.169 -12.216 1.00 56.53 ? 245 TYR B CE2 1 ATOM 4503 C CZ . TYR B 1 255 ? 81.744 75.286 -12.047 1.00 67.12 ? 245 TYR B CZ 1 ATOM 4504 O OH . TYR B 1 255 ? 82.381 74.810 -13.165 1.00 73.96 ? 245 TYR B OH 1 ATOM 4505 N N . VAL B 1 256 ? 78.723 75.606 -5.630 1.00 48.88 ? 246 VAL B N 1 ATOM 4506 C CA . VAL B 1 256 ? 78.428 75.859 -4.211 1.00 47.18 ? 246 VAL B CA 1 ATOM 4507 C C . VAL B 1 256 ? 79.653 75.873 -3.280 1.00 51.45 ? 246 VAL B C 1 ATOM 4508 O O . VAL B 1 256 ? 80.706 75.336 -3.611 1.00 51.95 ? 246 VAL B O 1 ATOM 4509 C CB . VAL B 1 256 ? 77.363 74.866 -3.663 1.00 49.60 ? 246 VAL B CB 1 ATOM 4510 C CG1 . VAL B 1 256 ? 75.996 75.046 -4.339 1.00 49.06 ? 246 VAL B CG1 1 ATOM 4511 C CG2 . VAL B 1 256 ? 77.840 73.416 -3.767 1.00 48.96 ? 246 VAL B CG2 1 ATOM 4512 N N . VAL B 1 257 ? 79.472 76.458 -2.089 1.00 47.32 ? 247 VAL B N 1 ATOM 4513 C CA . VAL B 1 257 ? 80.427 76.491 -0.976 1.00 46.57 ? 247 VAL B CA 1 ATOM 4514 C C . VAL B 1 257 ? 79.658 76.188 0.321 1.00 49.45 ? 247 VAL B C 1 ATOM 4515 O O . VAL B 1 257 ? 78.442 76.408 0.371 1.00 48.77 ? 247 VAL B O 1 ATOM 4516 C CB . VAL B 1 257 ? 81.189 77.834 -0.837 1.00 50.31 ? 247 VAL B CB 1 ATOM 4517 C CG1 . VAL B 1 257 ? 82.318 77.947 -1.844 1.00 50.32 ? 247 VAL B CG1 1 ATOM 4518 C CG2 . VAL B 1 257 ? 80.251 79.023 -0.916 1.00 50.19 ? 247 VAL B CG2 1 ATOM 4519 N N . LYS B 1 258 ? 80.361 75.726 1.377 1.00 45.43 ? 248 LYS B N 1 ATOM 4520 C CA . LYS B 1 258 ? 79.747 75.547 2.683 1.00 45.97 ? 248 LYS B CA 1 ATOM 4521 C C . LYS B 1 258 ? 79.371 76.986 3.094 1.00 53.78 ? 248 LYS B C 1 ATOM 4522 O O . LYS B 1 258 ? 80.200 77.882 2.942 1.00 54.96 ? 248 LYS B O 1 ATOM 4523 C CB . LYS B 1 258 ? 80.756 74.971 3.677 1.00 48.99 ? 248 LYS B CB 1 ATOM 4524 C CG . LYS B 1 258 ? 81.124 73.506 3.493 1.00 60.35 ? 248 LYS B CG 1 ATOM 4525 C CD . LYS B 1 258 ? 81.298 72.803 4.853 1.00 71.99 ? 248 LYS B CD 1 ATOM 4526 C CE . LYS B 1 258 ? 82.595 73.118 5.569 1.00 86.84 ? 248 LYS B CE 1 ATOM 4527 N NZ . LYS B 1 258 ? 82.450 73.032 7.048 1.00 96.08 ? 248 LYS B NZ 1 ATOM 4528 N N . CYS B 1 259 ? 78.121 77.234 3.519 1.00 51.06 ? 249 CYS B N 1 ATOM 4529 C CA . CYS B 1 259 ? 77.665 78.597 3.852 1.00 50.50 ? 249 CYS B CA 1 ATOM 4530 C C . CYS B 1 259 ? 78.607 79.372 4.824 1.00 52.56 ? 249 CYS B C 1 ATOM 4531 O O . CYS B 1 259 ? 78.865 80.559 4.600 1.00 51.17 ? 249 CYS B O 1 ATOM 4532 C CB . CYS B 1 259 ? 76.222 78.588 4.344 1.00 50.71 ? 249 CYS B CB 1 ATOM 4533 S SG . CYS B 1 259 ? 75.023 78.158 3.057 1.00 55.01 ? 249 CYS B SG 1 ATOM 4534 N N . ASN B 1 260 ? 79.153 78.696 5.846 1.00 48.69 ? 250 ASN B N 1 ATOM 4535 C CA . ASN B 1 260 ? 80.082 79.260 6.836 1.00 48.15 ? 250 ASN B CA 1 ATOM 4536 C C . ASN B 1 260 ? 81.414 79.704 6.206 1.00 52.68 ? 250 ASN B C 1 ATOM 4537 O O . ASN B 1 260 ? 82.017 80.672 6.670 1.00 51.06 ? 250 ASN B O 1 ATOM 4538 C CB . ASN B 1 260 ? 80.353 78.245 7.944 1.00 47.27 ? 250 ASN B CB 1 ATOM 4539 C CG . ASN B 1 260 ? 81.097 77.002 7.520 1.00 57.18 ? 250 ASN B CG 1 ATOM 4540 O OD1 . ASN B 1 260 ? 82.050 76.586 8.178 1.00 58.28 ? 250 ASN B OD1 1 ATOM 4541 N ND2 . ASN B 1 260 ? 80.646 76.345 6.458 1.00 39.20 ? 250 ASN B ND2 1 ATOM 4542 N N . GLU B 1 261 ? 81.856 78.978 5.158 1.00 49.71 ? 251 GLU B N 1 ATOM 4543 C CA . GLU B 1 261 ? 83.073 79.199 4.387 1.00 49.77 ? 251 GLU B CA 1 ATOM 4544 C C . GLU B 1 261 ? 83.008 80.441 3.511 1.00 54.72 ? 251 GLU B C 1 ATOM 4545 O O . GLU B 1 261 ? 84.040 80.956 3.106 1.00 54.21 ? 251 GLU B O 1 ATOM 4546 C CB . GLU B 1 261 ? 83.327 77.992 3.475 1.00 51.39 ? 251 GLU B CB 1 ATOM 4547 C CG . GLU B 1 261 ? 83.748 76.728 4.213 1.00 65.76 ? 251 GLU B CG 1 ATOM 4548 C CD . GLU B 1 261 ? 85.206 76.606 4.609 1.00 79.66 ? 251 GLU B CD 1 ATOM 4549 O OE1 . GLU B 1 261 ? 85.896 77.644 4.731 1.00 89.03 ? 251 GLU B OE1 1 ATOM 4550 O OE2 . GLU B 1 261 ? 85.657 75.457 4.815 1.00 64.61 ? 251 GLU B OE2 1 ATOM 4551 N N . GLY B 1 262 ? 81.811 80.851 3.137 1.00 52.41 ? 252 GLY B N 1 ATOM 4552 C CA . GLY B 1 262 ? 81.606 81.996 2.260 1.00 52.72 ? 252 GLY B CA 1 ATOM 4553 C C . GLY B 1 262 ? 82.424 83.213 2.650 1.00 55.42 ? 252 GLY B C 1 ATOM 4554 O O . GLY B 1 262 ? 83.267 83.648 1.859 1.00 54.60 ? 252 GLY B O 1 ATOM 4555 N N . PRO B 1 263 ? 82.268 83.707 3.907 1.00 51.20 ? 253 PRO B N 1 ATOM 4556 C CA . PRO B 1 263 ? 83.041 84.884 4.360 1.00 51.31 ? 253 PRO B CA 1 ATOM 4557 C C . PRO B 1 263 ? 84.554 84.797 4.153 1.00 58.09 ? 253 PRO B C 1 ATOM 4558 O O . PRO B 1 263 ? 85.240 85.812 3.980 1.00 60.18 ? 253 PRO B O 1 ATOM 4559 C CB . PRO B 1 263 ? 82.683 84.952 5.841 1.00 52.32 ? 253 PRO B CB 1 ATOM 4560 C CG . PRO B 1 263 ? 81.258 84.485 5.858 1.00 55.88 ? 253 PRO B CG 1 ATOM 4561 C CD . PRO B 1 263 ? 81.313 83.300 4.953 1.00 51.80 ? 253 PRO B CD 1 ATOM 4562 N N . THR B 1 264 ? 85.050 83.559 4.141 1.00 53.63 ? 254 THR B N 1 ATOM 4563 C CA . THR B 1 264 ? 86.430 83.125 3.983 1.00 52.47 ? 254 THR B CA 1 ATOM 4564 C C . THR B 1 264 ? 86.947 83.261 2.524 1.00 56.21 ? 254 THR B C 1 ATOM 4565 O O . THR B 1 264 ? 88.160 83.241 2.314 1.00 56.69 ? 254 THR B O 1 ATOM 4566 C CB . THR B 1 264 ? 86.456 81.665 4.516 1.00 54.95 ? 254 THR B CB 1 ATOM 4567 O OG1 . THR B 1 264 ? 87.028 81.619 5.831 1.00 63.32 ? 254 THR B OG1 1 ATOM 4568 C CG2 . THR B 1 264 ? 87.095 80.661 3.565 1.00 43.19 ? 254 THR B CG2 1 ATOM 4569 N N . LEU B 1 265 ? 86.044 83.323 1.523 1.00 51.88 ? 255 LEU B N 1 ATOM 4570 C CA . LEU B 1 265 ? 86.431 83.357 0.107 1.00 51.10 ? 255 LEU B CA 1 ATOM 4571 C C . LEU B 1 265 ? 87.107 84.670 -0.315 1.00 55.64 ? 255 LEU B C 1 ATOM 4572 O O . LEU B 1 265 ? 86.785 85.715 0.247 1.00 54.74 ? 255 LEU B O 1 ATOM 4573 C CB . LEU B 1 265 ? 85.247 83.024 -0.809 1.00 50.72 ? 255 LEU B CB 1 ATOM 4574 C CG . LEU B 1 265 ? 84.567 81.669 -0.641 1.00 53.95 ? 255 LEU B CG 1 ATOM 4575 C CD1 . LEU B 1 265 ? 83.591 81.433 -1.767 1.00 54.55 ? 255 LEU B CD1 1 ATOM 4576 C CD2 . LEU B 1 265 ? 85.555 80.532 -0.602 1.00 52.53 ? 255 LEU B CD2 1 ATOM 4577 N N . PRO B 1 266 ? 88.066 84.638 -1.276 1.00 53.48 ? 256 PRO B N 1 ATOM 4578 C CA . PRO B 1 266 ? 88.779 85.880 -1.645 1.00 52.69 ? 256 PRO B CA 1 ATOM 4579 C C . PRO B 1 266 ? 88.010 86.861 -2.524 1.00 54.14 ? 256 PRO B C 1 ATOM 4580 O O . PRO B 1 266 ? 87.047 86.492 -3.208 1.00 52.39 ? 256 PRO B O 1 ATOM 4581 C CB . PRO B 1 266 ? 90.010 85.362 -2.393 1.00 53.94 ? 256 PRO B CB 1 ATOM 4582 C CG . PRO B 1 266 ? 89.543 84.102 -3.025 1.00 58.72 ? 256 PRO B CG 1 ATOM 4583 C CD . PRO B 1 266 ? 88.590 83.478 -2.037 1.00 54.76 ? 256 PRO B CD 1 ATOM 4584 N N . ASP B 1 267 ? 88.499 88.111 -2.535 1.00 48.20 ? 257 ASP B N 1 ATOM 4585 C CA . ASP B 1 267 ? 87.975 89.180 -3.370 1.00 46.30 ? 257 ASP B CA 1 ATOM 4586 C C . ASP B 1 267 ? 88.184 88.825 -4.849 1.00 48.69 ? 257 ASP B C 1 ATOM 4587 O O . ASP B 1 267 ? 89.198 88.227 -5.196 1.00 48.36 ? 257 ASP B O 1 ATOM 4588 C CB . ASP B 1 267 ? 88.709 90.491 -3.046 1.00 46.82 ? 257 ASP B CB 1 ATOM 4589 C CG . ASP B 1 267 ? 88.408 91.135 -1.695 1.00 51.40 ? 257 ASP B CG 1 ATOM 4590 O OD1 . ASP B 1 267 ? 87.616 90.565 -0.923 1.00 51.89 ? 257 ASP B OD1 1 ATOM 4591 O OD2 . ASP B 1 267 ? 88.943 92.228 -1.428 1.00 59.90 ? 257 ASP B OD2 1 ATOM 4592 N N . ILE B 1 268 ? 87.216 89.147 -5.701 1.00 45.04 ? 258 ILE B N 1 ATOM 4593 C CA . ILE B 1 268 ? 87.337 88.935 -7.149 1.00 45.44 ? 258 ILE B CA 1 ATOM 4594 C C . ILE B 1 268 ? 87.387 90.314 -7.784 1.00 50.15 ? 258 ILE B C 1 ATOM 4595 O O . ILE B 1 268 ? 86.469 91.111 -7.568 1.00 51.17 ? 258 ILE B O 1 ATOM 4596 C CB . ILE B 1 268 ? 86.261 87.999 -7.771 1.00 48.18 ? 258 ILE B CB 1 ATOM 4597 C CG1 . ILE B 1 268 ? 86.339 86.585 -7.143 1.00 46.78 ? 258 ILE B CG1 1 ATOM 4598 C CG2 . ILE B 1 268 ? 86.425 87.949 -9.306 1.00 49.67 ? 258 ILE B CG2 1 ATOM 4599 C CD1 . ILE B 1 268 ? 85.281 85.644 -7.548 1.00 44.15 ? 258 ILE B CD1 1 ATOM 4600 N N . SER B 1 269 ? 88.503 90.635 -8.470 1.00 45.67 ? 259 SER B N 1 ATOM 4601 C CA . SER B 1 269 ? 88.725 91.947 -9.085 1.00 45.76 ? 259 SER B CA 1 ATOM 4602 C C . SER B 1 269 ? 88.665 91.899 -10.609 1.00 48.71 ? 259 SER B C 1 ATOM 4603 O O . SER B 1 269 ? 89.166 90.948 -11.210 1.00 49.01 ? 259 SER B O 1 ATOM 4604 C CB . SER B 1 269 ? 90.059 92.527 -8.618 1.00 51.12 ? 259 SER B CB 1 ATOM 4605 O OG . SER B 1 269 ? 90.042 92.868 -7.239 1.00 56.67 ? 259 SER B OG 1 ATOM 4606 N N . PHE B 1 270 ? 88.002 92.894 -11.228 1.00 44.00 ? 260 PHE B N 1 ATOM 4607 C CA . PHE B 1 270 ? 87.860 93.038 -12.692 1.00 42.79 ? 260 PHE B CA 1 ATOM 4608 C C . PHE B 1 270 ? 88.572 94.295 -13.132 1.00 48.03 ? 260 PHE B C 1 ATOM 4609 O O . PHE B 1 270 ? 88.217 95.401 -12.701 1.00 45.81 ? 260 PHE B O 1 ATOM 4610 C CB . PHE B 1 270 ? 86.374 93.054 -13.144 1.00 44.21 ? 260 PHE B CB 1 ATOM 4611 C CG . PHE B 1 270 ? 85.605 91.806 -12.775 1.00 45.50 ? 260 PHE B CG 1 ATOM 4612 C CD1 . PHE B 1 270 ? 85.016 91.675 -11.517 1.00 47.79 ? 260 PHE B CD1 1 ATOM 4613 C CD2 . PHE B 1 270 ? 85.495 90.745 -13.671 1.00 45.73 ? 260 PHE B CD2 1 ATOM 4614 C CE1 . PHE B 1 270 ? 84.305 90.517 -11.182 1.00 47.61 ? 260 PHE B CE1 1 ATOM 4615 C CE2 . PHE B 1 270 ? 84.807 89.578 -13.319 1.00 47.15 ? 260 PHE B CE2 1 ATOM 4616 C CZ . PHE B 1 270 ? 84.220 89.471 -12.082 1.00 44.97 ? 260 PHE B CZ 1 ATOM 4617 N N . HIS B 1 271 ? 89.647 94.112 -13.911 1.00 50.76 ? 261 HIS B N 1 ATOM 4618 C CA . HIS B 1 271 ? 90.463 95.212 -14.418 1.00 52.99 ? 261 HIS B CA 1 ATOM 4619 C C . HIS B 1 271 ? 89.791 95.809 -15.652 1.00 50.00 ? 261 HIS B C 1 ATOM 4620 O O . HIS B 1 271 ? 89.738 95.186 -16.713 1.00 47.66 ? 261 HIS B O 1 ATOM 4621 C CB . HIS B 1 271 ? 91.930 94.793 -14.708 1.00 56.73 ? 261 HIS B CB 1 ATOM 4622 C CG . HIS B 1 271 ? 92.899 95.949 -14.711 1.00 62.81 ? 261 HIS B CG 1 ATOM 4623 N ND1 . HIS B 1 271 ? 94.096 95.885 -14.019 1.00 66.16 ? 261 HIS B ND1 1 ATOM 4624 C CD2 . HIS B 1 271 ? 92.794 97.182 -15.271 1.00 66.39 ? 261 HIS B CD2 1 ATOM 4625 C CE1 . HIS B 1 271 ? 94.680 97.064 -14.182 1.00 66.14 ? 261 HIS B CE1 1 ATOM 4626 N NE2 . HIS B 1 271 ? 93.947 97.867 -14.948 1.00 66.64 ? 261 HIS B NE2 1 ATOM 4627 N N . LEU B 1 272 ? 89.281 97.029 -15.481 1.00 43.93 ? 262 LEU B N 1 ATOM 4628 C CA . LEU B 1 272 ? 88.561 97.804 -16.484 1.00 43.31 ? 262 LEU B CA 1 ATOM 4629 C C . LEU B 1 272 ? 88.991 99.268 -16.398 1.00 48.17 ? 262 LEU B C 1 ATOM 4630 O O . LEU B 1 272 ? 88.934 99.856 -15.323 1.00 47.96 ? 262 LEU B O 1 ATOM 4631 C CB . LEU B 1 272 ? 87.028 97.711 -16.238 1.00 42.72 ? 262 LEU B CB 1 ATOM 4632 C CG . LEU B 1 272 ? 86.401 96.332 -16.072 1.00 43.81 ? 262 LEU B CG 1 ATOM 4633 C CD1 . LEU B 1 272 ? 85.036 96.454 -15.511 1.00 41.34 ? 262 LEU B CD1 1 ATOM 4634 C CD2 . LEU B 1 272 ? 86.374 95.608 -17.383 1.00 47.50 ? 262 LEU B CD2 1 ATOM 4635 N N . GLY B 1 273 ? 89.398 99.832 -17.533 1.00 45.95 ? 263 GLY B N 1 ATOM 4636 C CA . GLY B 1 273 ? 89.858 101.212 -17.660 1.00 45.63 ? 263 GLY B CA 1 ATOM 4637 C C . GLY B 1 273 ? 91.051 101.559 -16.796 1.00 50.45 ? 263 GLY B C 1 ATOM 4638 O O . GLY B 1 273 ? 91.091 102.644 -16.197 1.00 49.08 ? 263 GLY B O 1 ATOM 4639 N N . GLY B 1 274 ? 91.973 100.606 -16.656 1.00 48.85 ? 264 GLY B N 1 ATOM 4640 C CA . GLY B 1 274 ? 93.149 100.796 -15.814 1.00 49.59 ? 264 GLY B CA 1 ATOM 4641 C C . GLY B 1 274 ? 92.843 100.805 -14.335 1.00 55.82 ? 264 GLY B C 1 ATOM 4642 O O . GLY B 1 274 ? 93.764 100.924 -13.522 1.00 56.55 ? 264 GLY B O 1 ATOM 4643 N N . LYS B 1 275 ? 91.528 100.654 -13.983 1.00 52.70 ? 265 LYS B N 1 ATOM 4644 C CA . LYS B 1 275 ? 90.951 100.597 -12.621 1.00 49.98 ? 265 LYS B CA 1 ATOM 4645 C C . LYS B 1 275 ? 90.611 99.156 -12.226 1.00 50.88 ? 265 LYS B C 1 ATOM 4646 O O . LYS B 1 275 ? 90.518 98.277 -13.090 1.00 50.79 ? 265 LYS B O 1 ATOM 4647 C CB . LYS B 1 275 ? 89.724 101.509 -12.483 1.00 50.17 ? 265 LYS B CB 1 ATOM 4648 C CG . LYS B 1 275 ? 90.038 102.983 -12.675 1.00 56.42 ? 265 LYS B CG 1 ATOM 4649 C CD . LYS B 1 275 ? 90.055 103.751 -11.372 1.00 66.85 ? 265 LYS B CD 1 ATOM 4650 C CE . LYS B 1 275 ? 90.626 105.148 -11.542 1.00 68.53 ? 265 LYS B CE 1 ATOM 4651 N NZ . LYS B 1 275 ? 90.760 105.855 -10.239 1.00 74.04 ? 265 LYS B NZ 1 ATOM 4652 N N . GLU B 1 276 ? 90.476 98.912 -10.910 1.00 44.85 ? 266 GLU B N 1 ATOM 4653 C CA . GLU B 1 276 ? 90.175 97.593 -10.369 1.00 43.00 ? 266 GLU B CA 1 ATOM 4654 C C . GLU B 1 276 ? 88.808 97.614 -9.684 1.00 44.00 ? 266 GLU B C 1 ATOM 4655 O O . GLU B 1 276 ? 88.600 98.356 -8.728 1.00 41.99 ? 266 GLU B O 1 ATOM 4656 C CB . GLU B 1 276 ? 91.268 97.136 -9.396 1.00 44.34 ? 266 GLU B CB 1 ATOM 4657 C CG . GLU B 1 276 ? 92.574 96.686 -10.043 1.00 53.64 ? 266 GLU B CG 1 ATOM 4658 C CD . GLU B 1 276 ? 92.599 95.378 -10.810 1.00 78.26 ? 266 GLU B CD 1 ATOM 4659 O OE1 . GLU B 1 276 ? 91.621 94.598 -10.754 1.00 78.04 ? 266 GLU B OE1 1 ATOM 4660 O OE2 . GLU B 1 276 ? 93.639 95.118 -11.450 1.00 79.44 ? 266 GLU B OE2 1 ATOM 4661 N N . TYR B 1 277 ? 87.865 96.818 -10.214 1.00 40.44 ? 267 TYR B N 1 ATOM 4662 C CA . TYR B 1 277 ? 86.495 96.677 -9.704 1.00 38.96 ? 267 TYR B CA 1 ATOM 4663 C C . TYR B 1 277 ? 86.413 95.383 -8.921 1.00 43.21 ? 267 TYR B C 1 ATOM 4664 O O . TYR B 1 277 ? 86.432 94.288 -9.484 1.00 43.10 ? 267 TYR B O 1 ATOM 4665 C CB . TYR B 1 277 ? 85.479 96.768 -10.860 1.00 38.40 ? 267 TYR B CB 1 ATOM 4666 C CG . TYR B 1 277 ? 85.463 98.157 -11.450 1.00 37.23 ? 267 TYR B CG 1 ATOM 4667 C CD1 . TYR B 1 277 ? 84.633 99.144 -10.930 1.00 38.32 ? 267 TYR B CD1 1 ATOM 4668 C CD2 . TYR B 1 277 ? 86.369 98.525 -12.451 1.00 36.78 ? 267 TYR B CD2 1 ATOM 4669 C CE1 . TYR B 1 277 ? 84.677 100.452 -11.410 1.00 37.64 ? 267 TYR B CE1 1 ATOM 4670 C CE2 . TYR B 1 277 ? 86.394 99.819 -12.962 1.00 35.94 ? 267 TYR B CE2 1 ATOM 4671 C CZ . TYR B 1 277 ? 85.548 100.777 -12.436 1.00 44.73 ? 267 TYR B CZ 1 ATOM 4672 O OH . TYR B 1 277 ? 85.579 102.055 -12.924 1.00 52.37 ? 267 TYR B OH 1 ATOM 4673 N N . THR B 1 278 ? 86.438 95.530 -7.603 1.00 41.22 ? 268 THR B N 1 ATOM 4674 C CA . THR B 1 278 ? 86.502 94.461 -6.621 1.00 41.76 ? 268 THR B CA 1 ATOM 4675 C C . THR B 1 278 ? 85.146 94.134 -5.989 1.00 45.80 ? 268 THR B C 1 ATOM 4676 O O . THR B 1 278 ? 84.441 95.022 -5.497 1.00 42.86 ? 268 THR B O 1 ATOM 4677 C CB . THR B 1 278 ? 87.577 94.832 -5.557 1.00 46.72 ? 268 THR B CB 1 ATOM 4678 O OG1 . THR B 1 278 ? 88.826 95.055 -6.215 1.00 52.80 ? 268 THR B OG1 1 ATOM 4679 C CG2 . THR B 1 278 ? 87.786 93.754 -4.498 1.00 38.69 ? 268 THR B CG2 1 ATOM 4680 N N . LEU B 1 279 ? 84.828 92.831 -5.969 1.00 43.15 ? 269 LEU B N 1 ATOM 4681 C CA . LEU B 1 279 ? 83.656 92.268 -5.310 1.00 42.55 ? 269 LEU B CA 1 ATOM 4682 C C . LEU B 1 279 ? 84.223 91.400 -4.186 1.00 44.95 ? 269 LEU B C 1 ATOM 4683 O O . LEU B 1 279 ? 85.168 90.634 -4.426 1.00 41.71 ? 269 LEU B O 1 ATOM 4684 C CB . LEU B 1 279 ? 82.861 91.344 -6.267 1.00 42.80 ? 269 LEU B CB 1 ATOM 4685 C CG . LEU B 1 279 ? 82.124 91.838 -7.550 1.00 47.88 ? 269 LEU B CG 1 ATOM 4686 C CD1 . LEU B 1 279 ? 80.661 91.450 -7.532 1.00 46.56 ? 269 LEU B CD1 1 ATOM 4687 C CD2 . LEU B 1 279 ? 82.268 93.319 -7.822 1.00 49.27 ? 269 LEU B CD2 1 ATOM 4688 N N . THR B 1 280 ? 83.653 91.501 -2.974 1.00 43.18 ? 270 THR B N 1 ATOM 4689 C CA . THR B 1 280 ? 84.049 90.634 -1.857 1.00 43.35 ? 270 THR B CA 1 ATOM 4690 C C . THR B 1 280 ? 83.116 89.422 -1.896 1.00 51.03 ? 270 THR B C 1 ATOM 4691 O O . THR B 1 280 ? 82.160 89.419 -2.681 1.00 51.04 ? 270 THR B O 1 ATOM 4692 C CB . THR B 1 280 ? 84.020 91.370 -0.521 1.00 44.28 ? 270 THR B CB 1 ATOM 4693 O OG1 . THR B 1 280 ? 82.694 91.794 -0.207 1.00 44.66 ? 270 THR B OG1 1 ATOM 4694 C CG2 . THR B 1 280 ? 84.964 92.547 -0.483 1.00 41.58 ? 270 THR B CG2 1 ATOM 4695 N N . SER B 1 281 ? 83.380 88.388 -1.078 1.00 48.72 ? 271 SER B N 1 ATOM 4696 C CA . SER B 1 281 ? 82.534 87.186 -1.033 1.00 47.70 ? 271 SER B CA 1 ATOM 4697 C C . SER B 1 281 ? 81.069 87.530 -0.691 1.00 51.42 ? 271 SER B C 1 ATOM 4698 O O . SER B 1 281 ? 80.153 86.882 -1.188 1.00 53.15 ? 271 SER B O 1 ATOM 4699 C CB . SER B 1 281 ? 83.129 86.145 -0.086 1.00 51.10 ? 271 SER B CB 1 ATOM 4700 O OG . SER B 1 281 ? 83.526 86.704 1.159 1.00 60.16 ? 271 SER B OG 1 ATOM 4701 N N . ALA B 1 282 ? 80.856 88.617 0.060 1.00 46.14 ? 272 ALA B N 1 ATOM 4702 C CA . ALA B 1 282 ? 79.528 89.109 0.414 1.00 45.36 ? 272 ALA B CA 1 ATOM 4703 C C . ALA B 1 282 ? 78.773 89.611 -0.835 1.00 49.72 ? 272 ALA B C 1 ATOM 4704 O O . ALA B 1 282 ? 77.551 89.694 -0.822 1.00 50.78 ? 272 ALA B O 1 ATOM 4705 C CB . ALA B 1 282 ? 79.652 90.235 1.425 1.00 45.34 ? 272 ALA B CB 1 ATOM 4706 N N . ASP B 1 283 ? 79.505 89.955 -1.900 1.00 44.59 ? 273 ASP B N 1 ATOM 4707 C CA . ASP B 1 283 ? 78.945 90.475 -3.148 1.00 42.08 ? 273 ASP B CA 1 ATOM 4708 C C . ASP B 1 283 ? 78.668 89.382 -4.170 1.00 45.11 ? 273 ASP B C 1 ATOM 4709 O O . ASP B 1 283 ? 77.942 89.638 -5.132 1.00 47.31 ? 273 ASP B O 1 ATOM 4710 C CB . ASP B 1 283 ? 79.900 91.509 -3.762 1.00 42.30 ? 273 ASP B CB 1 ATOM 4711 C CG . ASP B 1 283 ? 80.154 92.720 -2.892 1.00 45.84 ? 273 ASP B CG 1 ATOM 4712 O OD1 . ASP B 1 283 ? 79.177 93.281 -2.358 1.00 46.61 ? 273 ASP B OD1 1 ATOM 4713 O OD2 . ASP B 1 283 ? 81.334 93.136 -2.777 1.00 46.21 ? 273 ASP B OD2 1 ATOM 4714 N N . TYR B 1 284 ? 79.245 88.191 -4.004 1.00 40.25 ? 274 TYR B N 1 ATOM 4715 C CA . TYR B 1 284 ? 79.027 87.149 -5.003 1.00 40.69 ? 274 TYR B CA 1 ATOM 4716 C C . TYR B 1 284 ? 78.543 85.800 -4.426 1.00 46.22 ? 274 TYR B C 1 ATOM 4717 O O . TYR B 1 284 ? 78.262 84.891 -5.206 1.00 45.74 ? 274 TYR B O 1 ATOM 4718 C CB . TYR B 1 284 ? 80.256 86.965 -5.924 1.00 41.01 ? 274 TYR B CB 1 ATOM 4719 C CG . TYR B 1 284 ? 81.501 86.403 -5.272 1.00 41.75 ? 274 TYR B CG 1 ATOM 4720 C CD1 . TYR B 1 284 ? 81.668 85.029 -5.112 1.00 43.88 ? 274 TYR B CD1 1 ATOM 4721 C CD2 . TYR B 1 284 ? 82.570 87.233 -4.931 1.00 41.52 ? 274 TYR B CD2 1 ATOM 4722 C CE1 . TYR B 1 284 ? 82.827 84.504 -4.538 1.00 44.11 ? 274 TYR B CE1 1 ATOM 4723 C CE2 . TYR B 1 284 ? 83.747 86.716 -4.388 1.00 42.04 ? 274 TYR B CE2 1 ATOM 4724 C CZ . TYR B 1 284 ? 83.873 85.348 -4.191 1.00 51.95 ? 274 TYR B CZ 1 ATOM 4725 O OH . TYR B 1 284 ? 85.021 84.820 -3.635 1.00 55.00 ? 274 TYR B OH 1 ATOM 4726 N N . VAL B 1 285 ? 78.378 85.686 -3.094 1.00 44.07 ? 275 VAL B N 1 ATOM 4727 C CA . VAL B 1 285 ? 77.839 84.469 -2.484 1.00 44.88 ? 275 VAL B CA 1 ATOM 4728 C C . VAL B 1 285 ? 76.422 84.766 -1.998 1.00 47.98 ? 275 VAL B C 1 ATOM 4729 O O . VAL B 1 285 ? 76.220 85.775 -1.329 1.00 47.81 ? 275 VAL B O 1 ATOM 4730 C CB . VAL B 1 285 ? 78.721 83.913 -1.320 1.00 49.68 ? 275 VAL B CB 1 ATOM 4731 C CG1 . VAL B 1 285 ? 78.107 82.643 -0.733 1.00 49.62 ? 275 VAL B CG1 1 ATOM 4732 C CG2 . VAL B 1 285 ? 80.180 83.671 -1.757 1.00 48.88 ? 275 VAL B CG2 1 ATOM 4733 N N . PHE B 1 286 ? 75.443 83.896 -2.318 1.00 44.07 ? 276 PHE B N 1 ATOM 4734 C CA . PHE B 1 286 ? 74.071 84.060 -1.812 1.00 43.03 ? 276 PHE B CA 1 ATOM 4735 C C . PHE B 1 286 ? 74.059 83.443 -0.409 1.00 48.72 ? 276 PHE B C 1 ATOM 4736 O O . PHE B 1 286 ? 73.836 82.238 -0.244 1.00 48.51 ? 276 PHE B O 1 ATOM 4737 C CB . PHE B 1 286 ? 73.036 83.391 -2.726 1.00 43.38 ? 276 PHE B CB 1 ATOM 4738 C CG . PHE B 1 286 ? 72.830 84.029 -4.082 1.00 43.35 ? 276 PHE B CG 1 ATOM 4739 C CD1 . PHE B 1 286 ? 72.194 85.266 -4.205 1.00 44.25 ? 276 PHE B CD1 1 ATOM 4740 C CD2 . PHE B 1 286 ? 73.202 83.363 -5.240 1.00 43.21 ? 276 PHE B CD2 1 ATOM 4741 C CE1 . PHE B 1 286 ? 71.953 85.834 -5.463 1.00 44.11 ? 276 PHE B CE1 1 ATOM 4742 C CE2 . PHE B 1 286 ? 72.946 83.929 -6.503 1.00 45.14 ? 276 PHE B CE2 1 ATOM 4743 C CZ . PHE B 1 286 ? 72.320 85.163 -6.601 1.00 42.80 ? 276 PHE B CZ 1 ATOM 4744 N N . GLN B 1 287 ? 74.348 84.279 0.605 1.00 45.57 ? 277 GLN B N 1 ATOM 4745 C CA . GLN B 1 287 ? 74.409 83.840 1.995 1.00 45.08 ? 277 GLN B CA 1 ATOM 4746 C C . GLN B 1 287 ? 73.027 83.623 2.605 1.00 54.01 ? 277 GLN B C 1 ATOM 4747 O O . GLN B 1 287 ? 72.609 84.359 3.513 1.00 54.07 ? 277 GLN B O 1 ATOM 4748 C CB . GLN B 1 287 ? 75.276 84.767 2.853 1.00 45.01 ? 277 GLN B CB 1 ATOM 4749 C CG . GLN B 1 287 ? 76.749 84.859 2.414 1.00 40.05 ? 277 GLN B CG 1 ATOM 4750 C CD . GLN B 1 287 ? 77.664 83.677 2.705 1.00 57.25 ? 277 GLN B CD 1 ATOM 4751 O OE1 . GLN B 1 287 ? 78.857 83.732 2.392 1.00 56.99 ? 277 GLN B OE1 1 ATOM 4752 N NE2 . GLN B 1 287 ? 77.166 82.579 3.289 1.00 40.66 ? 277 GLN B NE2 1 ATOM 4753 N N . GLU B 1 288 ? 72.334 82.559 2.114 1.00 54.05 ? 278 GLU B N 1 ATOM 4754 C CA . GLU B 1 288 ? 71.015 82.083 2.577 1.00 55.23 ? 278 GLU B CA 1 ATOM 4755 C C . GLU B 1 288 ? 71.051 81.752 4.066 1.00 60.44 ? 278 GLU B C 1 ATOM 4756 O O . GLU B 1 288 ? 70.020 81.816 4.726 1.00 60.58 ? 278 GLU B O 1 ATOM 4757 C CB . GLU B 1 288 ? 70.564 80.835 1.782 1.00 56.96 ? 278 GLU B CB 1 ATOM 4758 C CG . GLU B 1 288 ? 70.153 81.108 0.341 1.00 65.92 ? 278 GLU B CG 1 ATOM 4759 C CD . GLU B 1 288 ? 69.045 82.131 0.165 1.00 79.43 ? 278 GLU B CD 1 ATOM 4760 O OE1 . GLU B 1 288 ? 67.887 81.814 0.527 1.00 67.19 ? 278 GLU B OE1 1 ATOM 4761 O OE2 . GLU B 1 288 ? 69.339 83.256 -0.307 1.00 68.95 ? 278 GLU B OE2 1 ATOM 4762 N N . SER B 1 289 ? 72.256 81.397 4.573 1.00 57.89 ? 279 SER B N 1 ATOM 4763 C CA . SER B 1 289 ? 72.609 81.124 5.959 1.00 57.73 ? 279 SER B CA 1 ATOM 4764 C C . SER B 1 289 ? 74.124 81.257 6.111 1.00 62.82 ? 279 SER B C 1 ATOM 4765 O O . SER B 1 289 ? 74.824 81.562 5.144 1.00 62.43 ? 279 SER B O 1 ATOM 4766 C CB . SER B 1 289 ? 72.130 79.733 6.380 1.00 60.19 ? 279 SER B CB 1 ATOM 4767 O OG . SER B 1 289 ? 72.909 78.667 5.862 1.00 62.60 ? 279 SER B OG 1 ATOM 4768 N N . TYR B 1 290 ? 74.631 81.065 7.319 1.00 60.68 ? 280 TYR B N 1 ATOM 4769 C CA . TYR B 1 290 ? 76.075 81.096 7.557 1.00 60.69 ? 280 TYR B CA 1 ATOM 4770 C C . TYR B 1 290 ? 76.464 79.782 8.279 1.00 64.37 ? 280 TYR B C 1 ATOM 4771 O O . TYR B 1 290 ? 77.497 79.686 8.963 1.00 63.71 ? 280 TYR B O 1 ATOM 4772 C CB . TYR B 1 290 ? 76.490 82.381 8.294 1.00 61.97 ? 280 TYR B CB 1 ATOM 4773 C CG . TYR B 1 290 ? 76.284 83.638 7.468 1.00 64.99 ? 280 TYR B CG 1 ATOM 4774 C CD1 . TYR B 1 290 ? 75.039 84.260 7.405 1.00 67.13 ? 280 TYR B CD1 1 ATOM 4775 C CD2 . TYR B 1 290 ? 77.344 84.229 6.782 1.00 66.00 ? 280 TYR B CD2 1 ATOM 4776 C CE1 . TYR B 1 290 ? 74.840 85.407 6.638 1.00 69.01 ? 280 TYR B CE1 1 ATOM 4777 C CE2 . TYR B 1 290 ? 77.163 85.394 6.035 1.00 66.95 ? 280 TYR B CE2 1 ATOM 4778 C CZ . TYR B 1 290 ? 75.908 85.984 5.973 1.00 76.91 ? 280 TYR B CZ 1 ATOM 4779 O OH . TYR B 1 290 ? 75.695 87.132 5.243 1.00 80.36 ? 280 TYR B OH 1 ATOM 4780 N N . SER B 1 291 ? 75.606 78.755 8.066 1.00 60.17 ? 281 SER B N 1 ATOM 4781 C CA . SER B 1 291 ? 75.700 77.408 8.620 1.00 59.40 ? 281 SER B CA 1 ATOM 4782 C C . SER B 1 291 ? 76.789 76.572 7.975 1.00 59.55 ? 281 SER B C 1 ATOM 4783 O O . SER B 1 291 ? 76.930 76.545 6.749 1.00 59.33 ? 281 SER B O 1 ATOM 4784 C CB . SER B 1 291 ? 74.360 76.685 8.493 1.00 63.31 ? 281 SER B CB 1 ATOM 4785 O OG . SER B 1 291 ? 74.434 75.371 9.009 1.00 74.88 ? 281 SER B OG 1 ATOM 4786 N N . SER B 1 292 A 77.507 75.836 8.824 1.00 53.39 ? 281 SER B N 1 ATOM 4787 C CA . SER B 1 292 A 78.524 74.847 8.456 1.00 52.27 ? 281 SER B CA 1 ATOM 4788 C C . SER B 1 292 A 77.840 73.540 7.947 1.00 52.70 ? 281 SER B C 1 ATOM 4789 O O . SER B 1 292 A 78.469 72.695 7.300 1.00 53.22 ? 281 SER B O 1 ATOM 4790 C CB . SER B 1 292 A 79.436 74.552 9.646 1.00 53.79 ? 281 SER B CB 1 ATOM 4791 O OG . SER B 1 292 A 78.729 74.588 10.879 1.00 60.39 ? 281 SER B OG 1 ATOM 4792 N N . LYS B 1 293 B 76.540 73.437 8.201 1.00 46.85 ? 281 LYS B N 1 ATOM 4793 C CA . LYS B 1 293 B 75.658 72.323 7.854 1.00 47.18 ? 281 LYS B CA 1 ATOM 4794 C C . LYS B 1 293 B 74.854 72.537 6.538 1.00 51.06 ? 281 LYS B C 1 ATOM 4795 O O . LYS B 1 293 B 74.038 71.691 6.172 1.00 50.33 ? 281 LYS B O 1 ATOM 4796 C CB . LYS B 1 293 B 74.698 72.051 9.052 1.00 48.78 ? 281 LYS B CB 1 ATOM 4797 C CG . LYS B 1 293 B 75.405 71.851 10.406 1.00 46.19 ? 281 LYS B CG 1 ATOM 4798 C CD . LYS B 1 293 B 74.462 72.078 11.582 1.00 52.80 ? 281 LYS B CD 1 ATOM 4799 C CE . LYS B 1 293 B 74.921 73.039 12.662 1.00 56.77 ? 281 LYS B CE 1 ATOM 4800 N NZ . LYS B 1 293 B 76.123 72.571 13.372 1.00 51.36 ? 281 LYS B NZ 1 ATOM 4801 N N . LYS B 1 294 C 75.089 73.653 5.837 1.00 49.28 ? 281 LYS B N 1 ATOM 4802 C CA . LYS B 1 294 C 74.376 73.981 4.600 1.00 48.80 ? 281 LYS B CA 1 ATOM 4803 C C . LYS B 1 294 C 75.278 74.445 3.457 1.00 49.77 ? 281 LYS B C 1 ATOM 4804 O O . LYS B 1 294 C 76.386 74.950 3.696 1.00 47.84 ? 281 LYS B O 1 ATOM 4805 C CB . LYS B 1 294 C 73.273 75.013 4.887 1.00 50.76 ? 281 LYS B CB 1 ATOM 4806 C CG . LYS B 1 294 C 71.976 74.364 5.360 1.00 55.67 ? 281 LYS B CG 1 ATOM 4807 C CD . LYS B 1 294 C 71.036 75.377 5.950 1.00 62.07 ? 281 LYS B CD 1 ATOM 4808 C CE . LYS B 1 294 C 69.973 74.727 6.792 1.00 70.00 ? 281 LYS B CE 1 ATOM 4809 N NZ . LYS B 1 294 C 69.347 75.706 7.720 1.00 79.86 ? 281 LYS B NZ 1 ATOM 4810 N N . LEU B 1 295 D 74.780 74.269 2.208 1.00 44.82 ? 281 LEU B N 1 ATOM 4811 C CA . LEU B 1 295 D 75.453 74.693 0.965 1.00 43.35 ? 281 LEU B CA 1 ATOM 4812 C C . LEU B 1 295 D 74.876 76.005 0.432 1.00 50.28 ? 281 LEU B C 1 ATOM 4813 O O . LEU B 1 295 D 73.660 76.210 0.479 1.00 50.09 ? 281 LEU B O 1 ATOM 4814 C CB . LEU B 1 295 D 75.384 73.622 -0.116 1.00 41.36 ? 281 LEU B CB 1 ATOM 4815 C CG . LEU B 1 295 D 76.069 72.302 0.189 1.00 42.30 ? 281 LEU B CG 1 ATOM 4816 C CD1 . LEU B 1 295 D 75.768 71.299 -0.910 1.00 41.68 ? 281 LEU B CD1 1 ATOM 4817 C CD2 . LEU B 1 295 D 77.581 72.472 0.461 1.00 34.13 ? 281 LEU B CD2 1 ATOM 4818 N N . CYS B 1 296 ? 75.755 76.897 -0.037 1.00 49.00 ? 282 CYS B N 1 ATOM 4819 C CA . CYS B 1 296 ? 75.406 78.229 -0.546 1.00 49.11 ? 282 CYS B CA 1 ATOM 4820 C C . CYS B 1 296 ? 75.830 78.386 -1.993 1.00 51.39 ? 282 CYS B C 1 ATOM 4821 O O . CYS B 1 296 ? 76.948 77.996 -2.338 1.00 51.48 ? 282 CYS B O 1 ATOM 4822 C CB . CYS B 1 296 ? 76.029 79.303 0.333 1.00 50.09 ? 282 CYS B CB 1 ATOM 4823 S SG . CYS B 1 296 ? 75.035 79.742 1.783 1.00 55.15 ? 282 CYS B SG 1 ATOM 4824 N N . THR B 1 297 ? 74.947 78.953 -2.838 1.00 45.44 ? 283 THR B N 1 ATOM 4825 C CA . THR B 1 297 ? 75.232 79.176 -4.264 1.00 43.63 ? 283 THR B CA 1 ATOM 4826 C C . THR B 1 297 ? 75.970 80.463 -4.527 1.00 46.35 ? 283 THR B C 1 ATOM 4827 O O . THR B 1 297 ? 75.906 81.386 -3.707 1.00 45.12 ? 283 THR B O 1 ATOM 4828 C CB . THR B 1 297 ? 73.959 79.107 -5.084 1.00 43.89 ? 283 THR B CB 1 ATOM 4829 O OG1 . THR B 1 297 ? 72.992 80.031 -4.565 1.00 46.87 ? 283 THR B OG1 1 ATOM 4830 C CG2 . THR B 1 297 ? 73.443 77.676 -5.189 1.00 36.90 ? 283 THR B CG2 1 ATOM 4831 N N . LEU B 1 298 ? 76.665 80.541 -5.685 1.00 43.43 ? 284 LEU B N 1 ATOM 4832 C CA . LEU B 1 298 ? 77.373 81.767 -6.089 1.00 42.07 ? 284 LEU B CA 1 ATOM 4833 C C . LEU B 1 298 ? 76.627 82.473 -7.224 1.00 42.95 ? 284 LEU B C 1 ATOM 4834 O O . LEU B 1 298 ? 75.956 81.818 -8.005 1.00 43.30 ? 284 LEU B O 1 ATOM 4835 C CB . LEU B 1 298 ? 78.851 81.529 -6.448 1.00 41.81 ? 284 LEU B CB 1 ATOM 4836 C CG . LEU B 1 298 ? 79.706 80.593 -5.552 1.00 46.12 ? 284 LEU B CG 1 ATOM 4837 C CD1 . LEU B 1 298 ? 81.179 80.783 -5.846 1.00 46.23 ? 284 LEU B CD1 1 ATOM 4838 C CD2 . LEU B 1 298 ? 79.524 80.849 -4.099 1.00 48.74 ? 284 LEU B CD2 1 ATOM 4839 N N . ALA B 1 299 ? 76.695 83.809 -7.268 1.00 39.77 ? 285 ALA B N 1 ATOM 4840 C CA . ALA B 1 299 ? 76.079 84.707 -8.251 1.00 39.55 ? 285 ALA B CA 1 ATOM 4841 C C . ALA B 1 299 ? 76.988 84.933 -9.473 1.00 45.25 ? 285 ALA B C 1 ATOM 4842 O O . ALA B 1 299 ? 77.010 86.024 -10.058 1.00 44.65 ? 285 ALA B O 1 ATOM 4843 C CB . ALA B 1 299 ? 75.760 86.031 -7.588 1.00 40.18 ? 285 ALA B CB 1 ATOM 4844 N N . ILE B 1 300 ? 77.766 83.888 -9.814 1.00 42.62 ? 286 ILE B N 1 ATOM 4845 C CA . ILE B 1 300 ? 78.695 83.747 -10.933 1.00 43.11 ? 286 ILE B CA 1 ATOM 4846 C C . ILE B 1 300 ? 78.387 82.389 -11.556 1.00 50.17 ? 286 ILE B C 1 ATOM 4847 O O . ILE B 1 300 ? 78.335 81.383 -10.839 1.00 49.62 ? 286 ILE B O 1 ATOM 4848 C CB . ILE B 1 300 ? 80.193 83.910 -10.514 1.00 45.63 ? 286 ILE B CB 1 ATOM 4849 C CG1 . ILE B 1 300 ? 80.400 85.256 -9.737 1.00 45.33 ? 286 ILE B CG1 1 ATOM 4850 C CG2 . ILE B 1 300 ? 81.112 83.819 -11.752 1.00 44.55 ? 286 ILE B CG2 1 ATOM 4851 C CD1 . ILE B 1 300 ? 81.783 85.468 -9.025 1.00 45.70 ? 286 ILE B CD1 1 ATOM 4852 N N . HIS B 1 301 ? 78.050 82.381 -12.857 1.00 50.35 ? 287 HIS B N 1 ATOM 4853 C CA . HIS B 1 301 ? 77.642 81.185 -13.618 1.00 51.36 ? 287 HIS B CA 1 ATOM 4854 C C . HIS B 1 301 ? 78.341 81.160 -14.948 1.00 59.16 ? 287 HIS B C 1 ATOM 4855 O O . HIS B 1 301 ? 78.649 82.213 -15.487 1.00 59.43 ? 287 HIS B O 1 ATOM 4856 C CB . HIS B 1 301 ? 76.132 81.210 -13.891 1.00 52.48 ? 287 HIS B CB 1 ATOM 4857 C CG . HIS B 1 301 ? 75.258 80.767 -12.756 1.00 57.45 ? 287 HIS B CG 1 ATOM 4858 N ND1 . HIS B 1 301 ? 75.410 81.278 -11.462 1.00 60.31 ? 287 HIS B ND1 1 ATOM 4859 C CD2 . HIS B 1 301 ? 74.187 79.937 -12.768 1.00 59.93 ? 287 HIS B CD2 1 ATOM 4860 C CE1 . HIS B 1 301 ? 74.471 80.691 -10.728 1.00 59.86 ? 287 HIS B CE1 1 ATOM 4861 N NE2 . HIS B 1 301 ? 73.716 79.871 -11.466 1.00 59.98 ? 287 HIS B NE2 1 ATOM 4862 N N . ALA B 1 302 ? 78.552 79.968 -15.517 1.00 58.33 ? 288 ALA B N 1 ATOM 4863 C CA . ALA B 1 302 ? 79.132 79.859 -16.857 1.00 57.38 ? 288 ALA B CA 1 ATOM 4864 C C . ALA B 1 302 ? 78.065 80.162 -17.908 1.00 61.23 ? 288 ALA B C 1 ATOM 4865 O O . ALA B 1 302 ? 76.879 79.828 -17.734 1.00 60.92 ? 288 ALA B O 1 ATOM 4866 C CB . ALA B 1 302 ? 79.699 78.471 -17.087 1.00 57.63 ? 288 ALA B CB 1 ATOM 4867 N N . MET B 1 303 ? 78.486 80.867 -18.959 1.00 56.93 ? 289 MET B N 1 ATOM 4868 C CA . MET B 1 303 ? 77.672 81.188 -20.118 1.00 56.35 ? 289 MET B CA 1 ATOM 4869 C C . MET B 1 303 ? 78.534 81.454 -21.328 1.00 62.10 ? 289 MET B C 1 ATOM 4870 O O . MET B 1 303 ? 79.323 82.402 -21.354 1.00 62.28 ? 289 MET B O 1 ATOM 4871 C CB . MET B 1 303 ? 76.650 82.295 -19.890 1.00 58.35 ? 289 MET B CB 1 ATOM 4872 C CG . MET B 1 303 ? 75.382 82.027 -20.684 1.00 61.52 ? 289 MET B CG 1 ATOM 4873 S SD . MET B 1 303 ? 74.280 83.415 -20.890 1.00 64.64 ? 289 MET B SD 1 ATOM 4874 C CE . MET B 1 303 ? 73.371 83.318 -19.397 1.00 61.04 ? 289 MET B CE 1 ATOM 4875 N N . ASP B 1 304 ? 78.419 80.566 -22.309 1.00 59.94 ? 290 ASP B N 1 ATOM 4876 C CA . ASP B 1 304 ? 79.158 80.648 -23.551 1.00 59.41 ? 290 ASP B CA 1 ATOM 4877 C C . ASP B 1 304 ? 78.314 81.457 -24.525 1.00 63.69 ? 290 ASP B C 1 ATOM 4878 O O . ASP B 1 304 ? 77.302 80.951 -25.061 1.00 65.22 ? 290 ASP B O 1 ATOM 4879 C CB . ASP B 1 304 ? 79.517 79.242 -24.070 1.00 60.96 ? 290 ASP B CB 1 ATOM 4880 C CG . ASP B 1 304 ? 80.306 78.390 -23.081 1.00 74.70 ? 290 ASP B CG 1 ATOM 4881 O OD1 . ASP B 1 304 ? 81.432 78.797 -22.697 1.00 76.24 ? 290 ASP B OD1 1 ATOM 4882 O OD2 . ASP B 1 304 ? 79.822 77.308 -22.725 1.00 82.21 ? 290 ASP B OD2 1 ATOM 4883 N N . ILE B 1 305 ? 78.659 82.769 -24.644 1.00 57.55 ? 291 ILE B N 1 ATOM 4884 C CA . ILE B 1 305 ? 77.977 83.691 -25.553 1.00 56.20 ? 291 ILE B CA 1 ATOM 4885 C C . ILE B 1 305 ? 78.561 83.421 -26.932 1.00 60.03 ? 291 ILE B C 1 ATOM 4886 O O . ILE B 1 305 ? 79.780 83.329 -27.064 1.00 59.37 ? 291 ILE B O 1 ATOM 4887 C CB . ILE B 1 305 ? 78.055 85.185 -25.103 1.00 58.88 ? 291 ILE B CB 1 ATOM 4888 C CG1 . ILE B 1 305 ? 77.196 85.432 -23.825 1.00 58.63 ? 291 ILE B CG1 1 ATOM 4889 C CG2 . ILE B 1 305 ? 77.619 86.160 -26.221 1.00 58.54 ? 291 ILE B CG2 1 ATOM 4890 C CD1 . ILE B 1 305 ? 77.980 85.814 -22.618 1.00 60.55 ? 291 ILE B CD1 1 ATOM 4891 N N . PRO B 1 306 ? 77.719 83.142 -27.944 1.00 58.34 ? 292 PRO B N 1 ATOM 4892 C CA . PRO B 1 306 ? 78.273 82.846 -29.273 1.00 58.19 ? 292 PRO B CA 1 ATOM 4893 C C . PRO B 1 306 ? 78.830 84.089 -29.996 1.00 64.70 ? 292 PRO B C 1 ATOM 4894 O O . PRO B 1 306 ? 78.417 85.214 -29.674 1.00 63.21 ? 292 PRO B O 1 ATOM 4895 C CB . PRO B 1 306 ? 77.066 82.280 -30.027 1.00 59.33 ? 292 PRO B CB 1 ATOM 4896 C CG . PRO B 1 306 ? 75.882 82.979 -29.426 1.00 63.69 ? 292 PRO B CG 1 ATOM 4897 C CD . PRO B 1 306 ? 76.233 83.131 -27.959 1.00 59.94 ? 292 PRO B CD 1 ATOM 4898 N N . PRO B 1 307 ? 79.694 83.913 -31.041 1.00 62.92 ? 293 PRO B N 1 ATOM 4899 C CA . PRO B 1 307 ? 80.125 85.071 -31.836 1.00 62.16 ? 293 PRO B CA 1 ATOM 4900 C C . PRO B 1 307 ? 78.948 85.591 -32.674 1.00 63.41 ? 293 PRO B C 1 ATOM 4901 O O . PRO B 1 307 ? 77.964 84.860 -32.849 1.00 62.83 ? 293 PRO B O 1 ATOM 4902 C CB . PRO B 1 307 ? 81.255 84.508 -32.710 1.00 64.46 ? 293 PRO B CB 1 ATOM 4903 C CG . PRO B 1 307 ? 81.558 83.130 -32.154 1.00 69.30 ? 293 PRO B CG 1 ATOM 4904 C CD . PRO B 1 307 ? 80.270 82.666 -31.585 1.00 64.99 ? 293 PRO B CD 1 ATOM 4905 N N . PRO B 1 308 ? 78.935 86.862 -33.119 1.00 57.78 ? 294 PRO B N 1 ATOM 4906 C CA . PRO B 1 308 ? 80.011 87.875 -33.059 1.00 57.13 ? 294 PRO B CA 1 ATOM 4907 C C . PRO B 1 308 ? 80.326 88.468 -31.677 1.00 58.44 ? 294 PRO B C 1 ATOM 4908 O O . PRO B 1 308 ? 81.485 88.827 -31.442 1.00 58.21 ? 294 PRO B O 1 ATOM 4909 C CB . PRO B 1 308 ? 79.522 88.949 -34.043 1.00 59.33 ? 294 PRO B CB 1 ATOM 4910 C CG . PRO B 1 308 ? 78.009 88.809 -34.041 1.00 63.43 ? 294 PRO B CG 1 ATOM 4911 C CD . PRO B 1 308 ? 77.772 87.341 -33.898 1.00 58.50 ? 294 PRO B CD 1 ATOM 4912 N N . THR B 1 309 ? 79.313 88.613 -30.789 1.00 53.06 ? 295 THR B N 1 ATOM 4913 C CA . THR B 1 309 ? 79.468 89.208 -29.451 1.00 52.65 ? 295 THR B CA 1 ATOM 4914 C C . THR B 1 309 ? 80.445 88.420 -28.574 1.00 58.30 ? 295 THR B C 1 ATOM 4915 O O . THR B 1 309 ? 81.319 89.007 -27.914 1.00 56.15 ? 295 THR B O 1 ATOM 4916 C CB . THR B 1 309 ? 78.105 89.412 -28.752 1.00 56.41 ? 295 THR B CB 1 ATOM 4917 O OG1 . THR B 1 309 ? 77.121 89.832 -29.696 1.00 56.63 ? 295 THR B OG1 1 ATOM 4918 C CG2 . THR B 1 309 ? 78.182 90.420 -27.603 1.00 52.04 ? 295 THR B CG2 1 ATOM 4919 N N . GLY B 1 310 ? 80.280 87.102 -28.580 1.00 57.66 ? 296 GLY B N 1 ATOM 4920 C CA . GLY B 1 310 ? 81.125 86.216 -27.801 1.00 58.52 ? 296 GLY B CA 1 ATOM 4921 C C . GLY B 1 310 ? 82.292 85.603 -28.559 1.00 65.06 ? 296 GLY B C 1 ATOM 4922 O O . GLY B 1 310 ? 82.442 85.809 -29.770 1.00 65.72 ? 296 GLY B O 1 ATOM 4923 N N . PRO B 1 311 ? 83.127 84.791 -27.873 1.00 61.08 ? 297 PRO B N 1 ATOM 4924 C CA . PRO B 1 311 ? 83.106 84.494 -26.433 1.00 60.30 ? 297 PRO B CA 1 ATOM 4925 C C . PRO B 1 311 ? 83.399 85.787 -25.658 1.00 63.36 ? 297 PRO B C 1 ATOM 4926 O O . PRO B 1 311 ? 84.222 86.600 -26.100 1.00 64.23 ? 297 PRO B O 1 ATOM 4927 C CB . PRO B 1 311 ? 84.231 83.448 -26.270 1.00 62.14 ? 297 PRO B CB 1 ATOM 4928 C CG . PRO B 1 311 ? 84.516 82.945 -27.659 1.00 66.76 ? 297 PRO B CG 1 ATOM 4929 C CD . PRO B 1 311 ? 84.271 84.139 -28.528 1.00 62.63 ? 297 PRO B CD 1 ATOM 4930 N N . THR B 1 312 ? 82.672 86.004 -24.535 1.00 56.58 ? 298 THR B N 1 ATOM 4931 C CA . THR B 1 312 ? 82.783 87.191 -23.686 1.00 53.29 ? 298 THR B CA 1 ATOM 4932 C C . THR B 1 312 ? 82.300 86.927 -22.276 1.00 54.81 ? 298 THR B C 1 ATOM 4933 O O . THR B 1 312 ? 81.483 86.038 -22.034 1.00 54.69 ? 298 THR B O 1 ATOM 4934 C CB . THR B 1 312 ? 81.971 88.361 -24.298 1.00 51.77 ? 298 THR B CB 1 ATOM 4935 O OG1 . THR B 1 312 ? 82.155 89.545 -23.531 1.00 51.86 ? 298 THR B OG1 1 ATOM 4936 C CG2 . THR B 1 312 ? 80.476 88.061 -24.423 1.00 43.61 ? 298 THR B CG2 1 ATOM 4937 N N . TRP B 1 313 ? 82.777 87.753 -21.345 1.00 49.91 ? 299 TRP B N 1 ATOM 4938 C CA . TRP B 1 313 ? 82.277 87.763 -19.982 1.00 47.54 ? 299 TRP B CA 1 ATOM 4939 C C . TRP B 1 313 ? 81.045 88.655 -20.054 1.00 44.39 ? 299 TRP B C 1 ATOM 4940 O O . TRP B 1 313 ? 80.930 89.472 -20.967 1.00 39.86 ? 299 TRP B O 1 ATOM 4941 C CB . TRP B 1 313 ? 83.279 88.384 -19.000 1.00 45.94 ? 299 TRP B CB 1 ATOM 4942 C CG . TRP B 1 313 ? 84.468 87.526 -18.710 1.00 46.81 ? 299 TRP B CG 1 ATOM 4943 C CD1 . TRP B 1 313 ? 85.545 87.308 -19.524 1.00 49.47 ? 299 TRP B CD1 1 ATOM 4944 C CD2 . TRP B 1 313 ? 84.767 86.873 -17.462 1.00 46.54 ? 299 TRP B CD2 1 ATOM 4945 N NE1 . TRP B 1 313 ? 86.477 86.519 -18.876 1.00 48.29 ? 299 TRP B NE1 1 ATOM 4946 C CE2 . TRP B 1 313 ? 86.016 86.221 -17.618 1.00 49.47 ? 299 TRP B CE2 1 ATOM 4947 C CE3 . TRP B 1 313 ? 84.070 86.723 -16.245 1.00 47.42 ? 299 TRP B CE3 1 ATOM 4948 C CZ2 . TRP B 1 313 ? 86.579 85.427 -16.609 1.00 48.55 ? 299 TRP B CZ2 1 ATOM 4949 C CZ3 . TRP B 1 313 ? 84.635 85.943 -15.240 1.00 48.91 ? 299 TRP B CZ3 1 ATOM 4950 C CH2 . TRP B 1 313 ? 85.879 85.312 -15.425 1.00 49.55 ? 299 TRP B CH2 1 ATOM 4951 N N . ALA B 1 314 ? 80.124 88.486 -19.112 1.00 41.56 ? 300 ALA B N 1 ATOM 4952 C CA . ALA B 1 314 ? 78.918 89.314 -19.029 1.00 40.80 ? 300 ALA B CA 1 ATOM 4953 C C . ALA B 1 314 ? 78.792 89.783 -17.587 1.00 43.84 ? 300 ALA B C 1 ATOM 4954 O O . ALA B 1 314 ? 78.775 88.960 -16.666 1.00 42.68 ? 300 ALA B O 1 ATOM 4955 C CB . ALA B 1 314 ? 77.694 88.534 -19.451 1.00 41.04 ? 300 ALA B CB 1 ATOM 4956 N N . LEU B 1 315 ? 78.792 91.107 -17.389 1.00 38.70 ? 301 LEU B N 1 ATOM 4957 C CA . LEU B 1 315 ? 78.689 91.722 -16.071 1.00 36.98 ? 301 LEU B CA 1 ATOM 4958 C C . LEU B 1 315 ? 77.215 92.088 -15.859 1.00 40.83 ? 301 LEU B C 1 ATOM 4959 O O . LEU B 1 315 ? 76.732 93.091 -16.392 1.00 42.86 ? 301 LEU B O 1 ATOM 4960 C CB . LEU B 1 315 ? 79.641 92.944 -15.966 1.00 36.70 ? 301 LEU B CB 1 ATOM 4961 C CG . LEU B 1 315 ? 81.152 92.681 -16.183 1.00 39.67 ? 301 LEU B CG 1 ATOM 4962 C CD1 . LEU B 1 315 ? 81.964 93.971 -16.167 1.00 38.57 ? 301 LEU B CD1 1 ATOM 4963 C CD2 . LEU B 1 315 ? 81.696 91.689 -15.174 1.00 40.94 ? 301 LEU B CD2 1 ATOM 4964 N N . GLY B 1 316 ? 76.488 91.197 -15.188 1.00 34.91 ? 302 GLY B N 1 ATOM 4965 C CA . GLY B 1 316 ? 75.056 91.337 -14.934 1.00 33.63 ? 302 GLY B CA 1 ATOM 4966 C C . GLY B 1 316 ? 74.754 91.966 -13.600 1.00 38.63 ? 302 GLY B C 1 ATOM 4967 O O . GLY B 1 316 ? 75.565 92.731 -13.076 1.00 39.52 ? 302 GLY B O 1 ATOM 4968 N N . ALA B 1 317 ? 73.577 91.651 -13.041 1.00 36.09 ? 303 ALA B N 1 ATOM 4969 C CA . ALA B 1 317 ? 73.111 92.187 -11.761 1.00 35.84 ? 303 ALA B CA 1 ATOM 4970 C C . ALA B 1 317 ? 74.135 92.088 -10.621 1.00 38.09 ? 303 ALA B C 1 ATOM 4971 O O . ALA B 1 317 ? 74.277 93.068 -9.859 1.00 38.63 ? 303 ALA B O 1 ATOM 4972 C CB . ALA B 1 317 ? 71.801 91.544 -11.364 1.00 36.58 ? 303 ALA B CB 1 ATOM 4973 N N . THR B 1 318 ? 74.903 90.965 -10.549 1.00 32.43 ? 304 THR B N 1 ATOM 4974 C CA . THR B 1 318 ? 75.938 90.759 -9.500 1.00 32.93 ? 304 THR B CA 1 ATOM 4975 C C . THR B 1 318 ? 76.928 91.928 -9.467 1.00 38.65 ? 304 THR B C 1 ATOM 4976 O O . THR B 1 318 ? 77.200 92.461 -8.391 1.00 38.58 ? 304 THR B O 1 ATOM 4977 C CB . THR B 1 318 ? 76.662 89.425 -9.673 1.00 41.22 ? 304 THR B CB 1 ATOM 4978 O OG1 . THR B 1 318 ? 75.691 88.409 -9.917 1.00 36.69 ? 304 THR B OG1 1 ATOM 4979 C CG2 . THR B 1 318 ? 77.594 89.066 -8.463 1.00 40.05 ? 304 THR B CG2 1 ATOM 4980 N N . PHE B 1 319 ? 77.397 92.361 -10.661 1.00 36.10 ? 305 PHE B N 1 ATOM 4981 C CA . PHE B 1 319 ? 78.314 93.492 -10.826 1.00 35.78 ? 305 PHE B CA 1 ATOM 4982 C C . PHE B 1 319 ? 77.630 94.829 -10.589 1.00 38.42 ? 305 PHE B C 1 ATOM 4983 O O . PHE B 1 319 ? 78.185 95.651 -9.869 1.00 39.56 ? 305 PHE B O 1 ATOM 4984 C CB . PHE B 1 319 ? 78.990 93.470 -12.218 1.00 36.92 ? 305 PHE B CB 1 ATOM 4985 C CG . PHE B 1 319 ? 80.191 94.388 -12.340 1.00 36.88 ? 305 PHE B CG 1 ATOM 4986 C CD1 . PHE B 1 319 ? 80.044 95.704 -12.762 1.00 37.61 ? 305 PHE B CD1 1 ATOM 4987 C CD2 . PHE B 1 319 ? 81.476 93.924 -12.069 1.00 36.36 ? 305 PHE B CD2 1 ATOM 4988 C CE1 . PHE B 1 319 ? 81.167 96.552 -12.871 1.00 36.56 ? 305 PHE B CE1 1 ATOM 4989 C CE2 . PHE B 1 319 ? 82.584 94.776 -12.171 1.00 37.25 ? 305 PHE B CE2 1 ATOM 4990 C CZ . PHE B 1 319 ? 82.426 96.091 -12.553 1.00 33.66 ? 305 PHE B CZ 1 ATOM 4991 N N . ILE B 1 320 ? 76.439 95.051 -11.173 1.00 33.64 ? 306 ILE B N 1 ATOM 4992 C CA . ILE B 1 320 ? 75.702 96.320 -11.076 1.00 33.83 ? 306 ILE B CA 1 ATOM 4993 C C . ILE B 1 320 ? 75.229 96.595 -9.634 1.00 38.03 ? 306 ILE B C 1 ATOM 4994 O O . ILE B 1 320 ? 75.133 97.756 -9.216 1.00 36.72 ? 306 ILE B O 1 ATOM 4995 C CB . ILE B 1 320 ? 74.565 96.382 -12.140 1.00 37.13 ? 306 ILE B CB 1 ATOM 4996 C CG1 . ILE B 1 320 ? 75.149 96.256 -13.572 1.00 37.73 ? 306 ILE B CG1 1 ATOM 4997 C CG2 . ILE B 1 320 ? 73.725 97.633 -12.017 1.00 35.42 ? 306 ILE B CG2 1 ATOM 4998 C CD1 . ILE B 1 320 ? 74.334 95.448 -14.515 1.00 52.44 ? 306 ILE B CD1 1 ATOM 4999 N N . ARG B 1 321 ? 75.001 95.550 -8.845 1.00 35.83 ? 307 ARG B N 1 ATOM 5000 C CA . ARG B 1 321 ? 74.624 95.771 -7.440 1.00 35.14 ? 307 ARG B CA 1 ATOM 5001 C C . ARG B 1 321 ? 75.733 96.507 -6.709 1.00 38.29 ? 307 ARG B C 1 ATOM 5002 O O . ARG B 1 321 ? 75.450 97.441 -5.967 1.00 38.33 ? 307 ARG B O 1 ATOM 5003 C CB . ARG B 1 321 ? 74.305 94.465 -6.729 1.00 31.04 ? 307 ARG B CB 1 ATOM 5004 C CG . ARG B 1 321 ? 72.826 94.121 -6.724 1.00 20.56 ? 307 ARG B CG 1 ATOM 5005 C CD . ARG B 1 321 ? 72.595 92.985 -5.743 1.00 31.88 ? 307 ARG B CD 1 ATOM 5006 N NE . ARG B 1 321 ? 73.233 91.733 -6.145 1.00 32.69 ? 307 ARG B NE 1 ATOM 5007 C CZ . ARG B 1 321 ? 72.693 90.848 -6.969 1.00 45.79 ? 307 ARG B CZ 1 ATOM 5008 N NH1 . ARG B 1 321 ? 71.511 91.083 -7.530 1.00 45.40 ? 307 ARG B NH1 1 ATOM 5009 N NH2 . ARG B 1 321 ? 73.335 89.727 -7.253 1.00 27.88 ? 307 ARG B NH2 1 ATOM 5010 N N . LYS B 1 322 ? 76.990 96.116 -6.944 1.00 34.63 ? 308 LYS B N 1 ATOM 5011 C CA . LYS B 1 322 ? 78.148 96.773 -6.326 1.00 35.54 ? 308 LYS B CA 1 ATOM 5012 C C . LYS B 1 322 ? 78.427 98.144 -6.979 1.00 41.01 ? 308 LYS B C 1 ATOM 5013 O O . LYS B 1 322 ? 78.683 99.121 -6.272 1.00 41.57 ? 308 LYS B O 1 ATOM 5014 C CB . LYS B 1 322 ? 79.389 95.858 -6.407 1.00 36.07 ? 308 LYS B CB 1 ATOM 5015 C CG . LYS B 1 322 ? 80.621 96.358 -5.657 1.00 41.80 ? 308 LYS B CG 1 ATOM 5016 C CD . LYS B 1 322 ? 80.572 96.191 -4.144 1.00 51.20 ? 308 LYS B CD 1 ATOM 5017 C CE . LYS B 1 322 ? 81.783 96.792 -3.477 1.00 49.66 ? 308 LYS B CE 1 ATOM 5018 N NZ . LYS B 1 322 ? 82.859 95.812 -3.309 1.00 64.96 ? 308 LYS B NZ 1 ATOM 5019 N N . PHE B 1 323 ? 78.326 98.215 -8.321 1.00 35.46 ? 309 PHE B N 1 ATOM 5020 C CA . PHE B 1 323 ? 78.650 99.417 -9.048 1.00 33.01 ? 309 PHE B CA 1 ATOM 5021 C C . PHE B 1 323 ? 77.506 100.016 -9.842 1.00 36.38 ? 309 PHE B C 1 ATOM 5022 O O . PHE B 1 323 ? 77.090 99.440 -10.856 1.00 35.99 ? 309 PHE B O 1 ATOM 5023 C CB . PHE B 1 323 ? 79.863 99.142 -9.962 1.00 34.07 ? 309 PHE B CB 1 ATOM 5024 C CG . PHE B 1 323 ? 81.065 98.627 -9.218 1.00 35.30 ? 309 PHE B CG 1 ATOM 5025 C CD1 . PHE B 1 323 ? 81.823 99.482 -8.404 1.00 38.01 ? 309 PHE B CD1 1 ATOM 5026 C CD2 . PHE B 1 323 ? 81.420 97.285 -9.289 1.00 35.81 ? 309 PHE B CD2 1 ATOM 5027 C CE1 . PHE B 1 323 ? 82.911 99.009 -7.689 1.00 37.67 ? 309 PHE B CE1 1 ATOM 5028 C CE2 . PHE B 1 323 ? 82.522 96.816 -8.590 1.00 38.12 ? 309 PHE B CE2 1 ATOM 5029 C CZ . PHE B 1 323 ? 83.262 97.681 -7.791 1.00 36.58 ? 309 PHE B CZ 1 ATOM 5030 N N . TYR B 1 324 ? 77.041 101.211 -9.411 1.00 32.45 ? 310 TYR B N 1 ATOM 5031 C CA . TYR B 1 324 ? 76.057 102.030 -10.122 1.00 31.99 ? 310 TYR B CA 1 ATOM 5032 C C . TYR B 1 324 ? 76.629 102.249 -11.562 1.00 37.61 ? 310 TYR B C 1 ATOM 5033 O O . TYR B 1 324 ? 77.806 102.563 -11.718 1.00 37.37 ? 310 TYR B O 1 ATOM 5034 C CB . TYR B 1 324 ? 75.848 103.357 -9.377 1.00 31.66 ? 310 TYR B CB 1 ATOM 5035 C CG . TYR B 1 324 ? 74.711 104.193 -9.917 1.00 34.32 ? 310 TYR B CG 1 ATOM 5036 C CD1 . TYR B 1 324 ? 74.897 105.041 -11.014 1.00 36.19 ? 310 TYR B CD1 1 ATOM 5037 C CD2 . TYR B 1 324 ? 73.457 104.170 -9.314 1.00 35.03 ? 310 TYR B CD2 1 ATOM 5038 C CE1 . TYR B 1 324 ? 73.856 105.818 -11.513 1.00 32.70 ? 310 TYR B CE1 1 ATOM 5039 C CE2 . TYR B 1 324 ? 72.410 104.951 -9.800 1.00 35.51 ? 310 TYR B CE2 1 ATOM 5040 C CZ . TYR B 1 324 ? 72.613 105.757 -10.911 1.00 42.53 ? 310 TYR B CZ 1 ATOM 5041 O OH . TYR B 1 324 ? 71.575 106.500 -11.408 1.00 47.21 ? 310 TYR B OH 1 ATOM 5042 N N . THR B 1 325 ? 75.821 101.999 -12.588 1.00 36.64 ? 311 THR B N 1 ATOM 5043 C CA . THR B 1 325 ? 76.272 102.043 -13.991 1.00 36.61 ? 311 THR B CA 1 ATOM 5044 C C . THR B 1 325 ? 75.576 103.119 -14.847 1.00 38.25 ? 311 THR B C 1 ATOM 5045 O O . THR B 1 325 ? 74.353 103.246 -14.810 1.00 36.41 ? 311 THR B O 1 ATOM 5046 C CB . THR B 1 325 ? 76.118 100.634 -14.603 1.00 38.44 ? 311 THR B CB 1 ATOM 5047 O OG1 . THR B 1 325 ? 76.741 99.710 -13.720 1.00 38.14 ? 311 THR B OG1 1 ATOM 5048 C CG2 . THR B 1 325 ? 76.745 100.502 -15.994 1.00 31.40 ? 311 THR B CG2 1 ATOM 5049 N N . GLU B 1 326 ? 76.371 103.893 -15.591 1.00 34.91 ? 312 GLU B N 1 ATOM 5050 C CA . GLU B 1 326 ? 75.884 104.904 -16.522 1.00 35.75 ? 312 GLU B CA 1 ATOM 5051 C C . GLU B 1 326 ? 76.282 104.503 -17.945 1.00 38.39 ? 312 GLU B C 1 ATOM 5052 O O . GLU B 1 326 ? 77.450 104.174 -18.208 1.00 38.51 ? 312 GLU B O 1 ATOM 5053 C CB . GLU B 1 326 ? 76.394 106.309 -16.168 1.00 37.35 ? 312 GLU B CB 1 ATOM 5054 C CG . GLU B 1 326 ? 75.823 107.390 -17.068 1.00 40.42 ? 312 GLU B CG 1 ATOM 5055 C CD . GLU B 1 326 ? 76.370 108.778 -16.826 1.00 56.09 ? 312 GLU B CD 1 ATOM 5056 O OE1 . GLU B 1 326 ? 77.518 109.043 -17.258 1.00 42.74 ? 312 GLU B OE1 1 ATOM 5057 O OE2 . GLU B 1 326 ? 75.665 109.592 -16.183 1.00 56.11 ? 312 GLU B OE2 1 ATOM 5058 N N . PHE B 1 327 ? 75.280 104.426 -18.830 1.00 34.75 ? 313 PHE B N 1 ATOM 5059 C CA . PHE B 1 327 ? 75.488 104.078 -20.243 1.00 34.19 ? 313 PHE B CA 1 ATOM 5060 C C . PHE B 1 327 ? 75.400 105.368 -21.038 1.00 40.01 ? 313 PHE B C 1 ATOM 5061 O O . PHE B 1 327 ? 74.364 106.046 -20.999 1.00 40.13 ? 313 PHE B O 1 ATOM 5062 C CB . PHE B 1 327 ? 74.507 103.019 -20.702 1.00 35.65 ? 313 PHE B CB 1 ATOM 5063 C CG . PHE B 1 327 ? 74.688 101.665 -20.047 1.00 37.65 ? 313 PHE B CG 1 ATOM 5064 C CD1 . PHE B 1 327 ? 74.009 101.345 -18.865 1.00 40.37 ? 313 PHE B CD1 1 ATOM 5065 C CD2 . PHE B 1 327 ? 75.529 100.699 -20.616 1.00 39.67 ? 313 PHE B CD2 1 ATOM 5066 C CE1 . PHE B 1 327 ? 74.146 100.078 -18.281 1.00 41.25 ? 313 PHE B CE1 1 ATOM 5067 C CE2 . PHE B 1 327 ? 75.667 99.430 -20.034 1.00 42.85 ? 313 PHE B CE2 1 ATOM 5068 C CZ . PHE B 1 327 ? 74.979 99.129 -18.867 1.00 41.42 ? 313 PHE B CZ 1 ATOM 5069 N N . ASP B 1 328 ? 76.560 105.789 -21.591 1.00 37.16 ? 314 ASP B N 1 ATOM 5070 C CA . ASP B 1 328 ? 76.761 107.050 -22.288 1.00 37.85 ? 314 ASP B CA 1 ATOM 5071 C C . ASP B 1 328 ? 76.724 106.841 -23.800 1.00 43.76 ? 314 ASP B C 1 ATOM 5072 O O . ASP B 1 328 ? 77.702 106.370 -24.390 1.00 43.85 ? 314 ASP B O 1 ATOM 5073 C CB . ASP B 1 328 ? 78.097 107.671 -21.820 1.00 39.42 ? 314 ASP B CB 1 ATOM 5074 C CG . ASP B 1 328 ? 78.406 109.098 -22.196 1.00 49.12 ? 314 ASP B CG 1 ATOM 5075 O OD1 . ASP B 1 328 ? 77.824 109.596 -23.182 1.00 50.45 ? 314 ASP B OD1 1 ATOM 5076 O OD2 . ASP B 1 328 ? 79.263 109.707 -21.526 1.00 53.75 ? 314 ASP B OD2 1 ATOM 5077 N N . ARG B 1 329 ? 75.588 107.190 -24.425 1.00 40.77 ? 315 ARG B N 1 ATOM 5078 C CA . ARG B 1 329 ? 75.440 107.071 -25.881 1.00 41.43 ? 315 ARG B CA 1 ATOM 5079 C C . ARG B 1 329 ? 76.190 108.180 -26.647 1.00 48.75 ? 315 ARG B C 1 ATOM 5080 O O . ARG B 1 329 ? 76.635 107.958 -27.776 1.00 50.21 ? 315 ARG B O 1 ATOM 5081 C CB . ARG B 1 329 ? 73.965 107.059 -26.296 1.00 38.83 ? 315 ARG B CB 1 ATOM 5082 C CG . ARG B 1 329 ? 73.256 105.718 -26.104 1.00 39.14 ? 315 ARG B CG 1 ATOM 5083 C CD . ARG B 1 329 ? 73.731 104.616 -27.053 1.00 50.21 ? 315 ARG B CD 1 ATOM 5084 N NE . ARG B 1 329 ? 73.574 104.916 -28.476 1.00 55.25 ? 315 ARG B NE 1 ATOM 5085 C CZ . ARG B 1 329 ? 72.475 104.655 -29.172 1.00 74.69 ? 315 ARG B CZ 1 ATOM 5086 N NH1 . ARG B 1 329 ? 71.410 104.132 -28.576 1.00 63.29 ? 315 ARG B NH1 1 ATOM 5087 N NH2 . ARG B 1 329 ? 72.423 104.937 -30.467 1.00 68.13 ? 315 ARG B NH2 1 ATOM 5088 N N . ARG B 1 330 ? 76.312 109.372 -26.038 1.00 46.42 ? 316 ARG B N 1 ATOM 5089 C CA . ARG B 1 330 ? 77.017 110.498 -26.631 1.00 47.01 ? 316 ARG B CA 1 ATOM 5090 C C . ARG B 1 330 ? 78.519 110.189 -26.857 1.00 52.08 ? 316 ARG B C 1 ATOM 5091 O O . ARG B 1 330 ? 79.068 110.533 -27.915 1.00 52.39 ? 316 ARG B O 1 ATOM 5092 C CB . ARG B 1 330 ? 76.832 111.758 -25.763 1.00 45.79 ? 316 ARG B CB 1 ATOM 5093 C CG . ARG B 1 330 ? 77.611 113.004 -26.218 1.00 53.18 ? 316 ARG B CG 1 ATOM 5094 C CD . ARG B 1 330 ? 77.386 113.464 -27.661 1.00 53.29 ? 316 ARG B CD 1 ATOM 5095 N NE . ARG B 1 330 ? 78.292 114.572 -27.985 1.00 55.55 ? 316 ARG B NE 1 ATOM 5096 C CZ . ARG B 1 330 ? 79.467 114.449 -28.604 1.00 68.53 ? 316 ARG B CZ 1 ATOM 5097 N NH1 . ARG B 1 330 ? 79.883 113.260 -29.032 1.00 59.39 ? 316 ARG B NH1 1 ATOM 5098 N NH2 . ARG B 1 330 ? 80.223 115.516 -28.820 1.00 45.85 ? 316 ARG B NH2 1 ATOM 5099 N N . ASN B 1 331 ? 79.165 109.533 -25.877 1.00 46.74 ? 317 ASN B N 1 ATOM 5100 C CA . ASN B 1 331 ? 80.593 109.287 -25.954 1.00 45.73 ? 317 ASN B CA 1 ATOM 5101 C C . ASN B 1 331 ? 80.980 107.832 -26.123 1.00 49.92 ? 317 ASN B C 1 ATOM 5102 O O . ASN B 1 331 ? 82.169 107.524 -26.051 1.00 51.08 ? 317 ASN B O 1 ATOM 5103 C CB . ASN B 1 331 ? 81.273 109.900 -24.727 1.00 40.91 ? 317 ASN B CB 1 ATOM 5104 C CG . ASN B 1 331 ? 81.068 111.388 -24.600 1.00 51.46 ? 317 ASN B CG 1 ATOM 5105 O OD1 . ASN B 1 331 ? 81.290 112.154 -25.521 1.00 57.59 ? 317 ASN B OD1 1 ATOM 5106 N ND2 . ASN B 1 331 ? 80.728 111.838 -23.427 1.00 33.46 ? 317 ASN B ND2 1 ATOM 5107 N N . ASN B 1 332 ? 80.001 106.942 -26.388 1.00 46.27 ? 318 ASN B N 1 ATOM 5108 C CA . ASN B 1 332 ? 80.201 105.485 -26.539 1.00 45.40 ? 318 ASN B CA 1 ATOM 5109 C C . ASN B 1 332 ? 81.122 104.936 -25.457 1.00 46.93 ? 318 ASN B C 1 ATOM 5110 O O . ASN B 1 332 ? 82.233 104.472 -25.731 1.00 45.85 ? 318 ASN B O 1 ATOM 5111 C CB . ASN B 1 332 ? 80.657 105.091 -27.941 1.00 47.69 ? 318 ASN B CB 1 ATOM 5112 C CG . ASN B 1 332 ? 79.602 105.285 -28.993 1.00 65.16 ? 318 ASN B CG 1 ATOM 5113 O OD1 . ASN B 1 332 ? 79.611 106.269 -29.734 1.00 66.92 ? 318 ASN B OD1 1 ATOM 5114 N ND2 . ASN B 1 332 ? 78.671 104.364 -29.069 1.00 50.56 ? 318 ASN B ND2 1 ATOM 5115 N N . ARG B 1 333 ? 80.654 105.054 -24.198 1.00 42.50 ? 319 ARG B N 1 ATOM 5116 C CA . ARG B 1 333 ? 81.382 104.626 -23.004 1.00 41.79 ? 319 ARG B CA 1 ATOM 5117 C C . ARG B 1 333 ? 80.424 104.254 -21.884 1.00 45.17 ? 319 ARG B C 1 ATOM 5118 O O . ARG B 1 333 ? 79.259 104.657 -21.909 1.00 45.73 ? 319 ARG B O 1 ATOM 5119 C CB . ARG B 1 333 ? 82.388 105.716 -22.541 1.00 38.36 ? 319 ARG B CB 1 ATOM 5120 C CG . ARG B 1 333 ? 81.740 107.041 -22.189 1.00 36.24 ? 319 ARG B CG 1 ATOM 5121 C CD . ARG B 1 333 ? 82.736 108.039 -21.664 1.00 38.23 ? 319 ARG B CD 1 ATOM 5122 N NE . ARG B 1 333 ? 82.064 109.205 -21.092 1.00 36.58 ? 319 ARG B NE 1 ATOM 5123 C CZ . ARG B 1 333 ? 82.672 110.150 -20.380 1.00 47.79 ? 319 ARG B CZ 1 ATOM 5124 N NH1 . ARG B 1 333 ? 83.978 110.082 -20.154 1.00 41.90 ? 319 ARG B NH1 1 ATOM 5125 N NH2 . ARG B 1 333 ? 81.979 111.170 -19.887 1.00 32.79 ? 319 ARG B NH2 1 ATOM 5126 N N . ILE B 1 334 ? 80.928 103.509 -20.892 1.00 40.88 ? 320 ILE B N 1 ATOM 5127 C CA . ILE B 1 334 ? 80.187 103.089 -19.700 1.00 40.83 ? 320 ILE B CA 1 ATOM 5128 C C . ILE B 1 334 ? 80.923 103.647 -18.477 1.00 47.75 ? 320 ILE B C 1 ATOM 5129 O O . ILE B 1 334 ? 82.128 103.408 -18.336 1.00 47.97 ? 320 ILE B O 1 ATOM 5130 C CB . ILE B 1 334 ? 80.057 101.537 -19.640 1.00 42.75 ? 320 ILE B CB 1 ATOM 5131 C CG1 . ILE B 1 334 ? 79.222 100.972 -20.807 1.00 42.25 ? 320 ILE B CG1 1 ATOM 5132 C CG2 . ILE B 1 334 ? 79.525 101.061 -18.280 1.00 42.93 ? 320 ILE B CG2 1 ATOM 5133 C CD1 . ILE B 1 334 ? 79.447 99.531 -21.058 1.00 40.62 ? 320 ILE B CD1 1 ATOM 5134 N N . GLY B 1 335 ? 80.187 104.334 -17.595 1.00 44.45 ? 321 GLY B N 1 ATOM 5135 C CA . GLY B 1 335 ? 80.713 104.862 -16.342 1.00 43.67 ? 321 GLY B CA 1 ATOM 5136 C C . GLY B 1 335 ? 80.300 104.034 -15.144 1.00 47.27 ? 321 GLY B C 1 ATOM 5137 O O . GLY B 1 335 ? 79.177 103.542 -15.097 1.00 48.66 ? 321 GLY B O 1 ATOM 5138 N N . PHE B 1 336 ? 81.196 103.872 -14.161 1.00 41.56 ? 322 PHE B N 1 ATOM 5139 C CA . PHE B 1 336 ? 80.913 103.133 -12.938 1.00 39.44 ? 322 PHE B CA 1 ATOM 5140 C C . PHE B 1 336 ? 81.255 103.930 -11.697 1.00 42.94 ? 322 PHE B C 1 ATOM 5141 O O . PHE B 1 336 ? 82.297 104.578 -11.616 1.00 44.80 ? 322 PHE B O 1 ATOM 5142 C CB . PHE B 1 336 ? 81.689 101.808 -12.895 1.00 40.73 ? 322 PHE B CB 1 ATOM 5143 C CG . PHE B 1 336 ? 81.362 100.750 -13.923 1.00 41.79 ? 322 PHE B CG 1 ATOM 5144 C CD1 . PHE B 1 336 ? 80.112 100.150 -13.954 1.00 43.94 ? 322 PHE B CD1 1 ATOM 5145 C CD2 . PHE B 1 336 ? 82.332 100.296 -14.809 1.00 44.35 ? 322 PHE B CD2 1 ATOM 5146 C CE1 . PHE B 1 336 ? 79.823 99.143 -14.887 1.00 45.46 ? 322 PHE B CE1 1 ATOM 5147 C CE2 . PHE B 1 336 ? 82.045 99.289 -15.751 1.00 46.02 ? 322 PHE B CE2 1 ATOM 5148 C CZ . PHE B 1 336 ? 80.794 98.722 -15.784 1.00 44.39 ? 322 PHE B CZ 1 ATOM 5149 N N . ALA B 1 337 ? 80.410 103.844 -10.704 1.00 39.62 ? 323 ALA B N 1 ATOM 5150 C CA . ALA B 1 337 ? 80.670 104.475 -9.395 1.00 38.86 ? 323 ALA B CA 1 ATOM 5151 C C . ALA B 1 337 ? 80.135 103.505 -8.364 1.00 45.43 ? 323 ALA B C 1 ATOM 5152 O O . ALA B 1 337 ? 79.290 102.662 -8.680 1.00 44.95 ? 323 ALA B O 1 ATOM 5153 C CB . ALA B 1 337 ? 79.986 105.843 -9.272 1.00 38.38 ? 323 ALA B CB 1 ATOM 5154 N N . LEU B 1 338 ? 80.664 103.578 -7.145 1.00 43.34 ? 324 LEU B N 1 ATOM 5155 C CA . LEU B 1 338 ? 80.255 102.704 -6.052 1.00 42.05 ? 324 LEU B CA 1 ATOM 5156 C C . LEU B 1 338 ? 78.792 102.982 -5.651 1.00 43.66 ? 324 LEU B C 1 ATOM 5157 O O . LEU B 1 338 ? 78.421 104.126 -5.383 1.00 41.29 ? 324 LEU B O 1 ATOM 5158 C CB . LEU B 1 338 ? 81.216 102.920 -4.898 1.00 42.42 ? 324 LEU B CB 1 ATOM 5159 C CG . LEU B 1 338 ? 81.103 101.999 -3.708 1.00 47.74 ? 324 LEU B CG 1 ATOM 5160 C CD1 . LEU B 1 338 ? 81.415 100.569 -4.089 1.00 47.67 ? 324 LEU B CD1 1 ATOM 5161 C CD2 . LEU B 1 338 ? 82.028 102.470 -2.599 1.00 49.58 ? 324 LEU B CD2 1 ATOM 5162 N N . ALA B 1 339 ? 77.951 101.936 -5.689 1.00 40.07 ? 325 ALA B N 1 ATOM 5163 C CA . ALA B 1 339 ? 76.539 102.070 -5.357 1.00 39.18 ? 325 ALA B CA 1 ATOM 5164 C C . ALA B 1 339 ? 76.256 102.264 -3.872 1.00 44.89 ? 325 ALA B C 1 ATOM 5165 O O . ALA B 1 339 ? 77.009 101.803 -3.002 1.00 45.81 ? 325 ALA B O 1 ATOM 5166 C CB . ALA B 1 339 ? 75.757 100.883 -5.878 1.00 39.43 ? 325 ALA B CB 1 ATOM 5167 N N . ARG B 1 340 ? 75.083 102.874 -3.605 1.00 40.26 ? 326 ARG B N 1 ATOM 5168 C CA . ARG B 1 340 ? 74.485 103.139 -2.296 1.00 42.46 ? 326 ARG B CA 1 ATOM 5169 C C . ARG B 1 340 ? 73.004 102.661 -2.384 1.00 61.78 ? 326 ARG B C 1 ATOM 5170 O O . ARG B 1 340 ? 72.781 101.425 -2.361 1.00 78.16 ? 326 ARG B O 1 ATOM 5171 C CB . ARG B 1 340 ? 74.500 104.646 -1.988 1.00 41.67 ? 326 ARG B CB 1 ATOM 5172 C CG . ARG B 1 340 ? 75.809 105.234 -1.685 1.00 42.83 ? 326 ARG B CG 1 ATOM 5173 C CD . ARG B 1 340 ? 75.567 106.526 -0.959 1.00 60.17 ? 326 ARG B CD 1 ATOM 5174 N NE . ARG B 1 340 ? 75.259 107.686 -1.800 1.00 63.00 ? 326 ARG B NE 1 ATOM 5175 C CZ . ARG B 1 340 ? 74.724 108.811 -1.322 1.00 78.66 ? 326 ARG B CZ 1 ATOM 5176 N NH1 . ARG B 1 340 ? 74.398 108.906 -0.038 1.00 70.54 ? 326 ARG B NH1 1 ATOM 5177 N NH2 . ARG B 1 340 ? 74.483 109.835 -2.127 1.00 65.23 ? 326 ARG B NH2 1 ATOM 5178 O OXT . ARG B 1 340 ? 72.082 103.499 -2.602 1.00 52.45 ? 326 ARG B OXT 1 HETATM 5179 C C1 . NAG C 2 . ? 36.941 128.691 23.410 1.00 84.44 ? 1000 NAG A C1 1 HETATM 5180 C C2 . NAG C 2 . ? 36.211 129.728 24.268 1.00 83.92 ? 1000 NAG A C2 1 HETATM 5181 C C3 . NAG C 2 . ? 34.876 130.024 23.588 1.00 89.50 ? 1000 NAG A C3 1 HETATM 5182 C C4 . NAG C 2 . ? 35.128 130.589 22.195 1.00 92.34 ? 1000 NAG A C4 1 HETATM 5183 C C5 . NAG C 2 . ? 35.927 129.582 21.367 1.00 91.68 ? 1000 NAG A C5 1 HETATM 5184 C C6 . NAG C 2 . ? 36.371 130.126 20.027 1.00 94.19 ? 1000 NAG A C6 1 HETATM 5185 C C7 . NAG C 2 . ? 36.704 129.859 26.688 1.00 78.80 ? 1000 NAG A C7 1 HETATM 5186 C C8 . NAG C 2 . ? 36.309 129.372 28.050 1.00 76.39 ? 1000 NAG A C8 1 HETATM 5187 N N2 . NAG C 2 . ? 36.013 129.331 25.652 1.00 79.99 ? 1000 NAG A N2 1 HETATM 5188 O O3 . NAG C 2 . ? 34.116 130.950 24.360 1.00 92.25 ? 1000 NAG A O3 1 HETATM 5189 O O4 . NAG C 2 . ? 33.904 130.942 21.560 1.00 95.59 ? 1000 NAG A O4 1 HETATM 5190 O O5 . NAG C 2 . ? 37.125 129.206 22.075 1.00 88.77 ? 1000 NAG A O5 1 HETATM 5191 O O6 . NAG C 2 . ? 35.294 130.670 19.263 1.00 96.63 ? 1000 NAG A O6 1 HETATM 5192 O O7 . NAG C 2 . ? 37.604 130.687 26.532 1.00 78.37 ? 1000 NAG A O7 1 HETATM 5193 C C1 . 3ZJ D 3 . ? 44.138 106.584 12.022 1.00 71.34 ? 1001 3ZJ A C1 1 HETATM 5194 C C3 . 3ZJ D 3 . ? 42.752 108.633 11.650 1.00 70.17 ? 1001 3ZJ A C3 1 HETATM 5195 C C11 . 3ZJ D 3 . ? 37.687 106.964 8.787 1.00 82.34 ? 1001 3ZJ A C11 1 HETATM 5196 C C13 . 3ZJ D 3 . ? 47.671 104.469 13.511 1.00 61.43 ? 1001 3ZJ A C13 1 HETATM 5197 C C14 . 3ZJ D 3 . ? 45.357 105.234 13.820 1.00 62.45 ? 1001 3ZJ A C14 1 HETATM 5198 C C15 . 3ZJ D 3 . ? 45.018 108.749 12.806 1.00 69.88 ? 1001 3ZJ A C15 1 HETATM 5199 C C16 . 3ZJ D 3 . ? 46.504 104.575 14.310 1.00 61.78 ? 1001 3ZJ A C16 1 HETATM 5200 C C17 . 3ZJ D 3 . ? 43.125 108.926 9.047 1.00 70.19 ? 1001 3ZJ A C17 1 HETATM 5201 C C18 . 3ZJ D 3 . ? 41.073 110.175 9.055 1.00 72.58 ? 1001 3ZJ A C18 1 HETATM 5202 C C20 . 3ZJ D 3 . ? 36.988 108.276 8.414 1.00 80.28 ? 1001 3ZJ A C20 1 HETATM 5203 C C22 . 3ZJ D 3 . ? 49.551 107.065 10.269 1.00 41.83 ? 1001 3ZJ A C22 1 HETATM 5204 C C24 . 3ZJ D 3 . ? 49.017 105.620 10.154 1.00 45.81 ? 1001 3ZJ A C24 1 HETATM 5205 C C25 . 3ZJ D 3 . ? 49.520 107.819 8.913 1.00 39.79 ? 1001 3ZJ A C25 1 HETATM 5206 C C26 . 3ZJ D 3 . ? 45.732 109.818 11.928 1.00 68.50 ? 1001 3ZJ A C26 1 HETATM 5207 C C27 . 3ZJ D 3 . ? 44.566 109.225 14.212 1.00 70.29 ? 1001 3ZJ A C27 1 HETATM 5208 C C28 . 3ZJ D 3 . ? 35.758 108.637 9.012 1.00 78.76 ? 1001 3ZJ A C28 1 HETATM 5209 C C29 . 3ZJ D 3 . ? 37.574 109.125 7.458 1.00 79.51 ? 1001 3ZJ A C29 1 HETATM 5210 C C30 . 3ZJ D 3 . ? 48.848 102.630 14.798 1.00 60.35 ? 1001 3ZJ A C30 1 HETATM 5211 N N2 . 3ZJ D 3 . ? 43.986 107.959 12.107 1.00 70.44 ? 1001 3ZJ A N2 1 HETATM 5212 C C4 . 3ZJ D 3 . ? 42.269 108.375 10.201 1.00 70.84 ? 1001 3ZJ A C4 1 HETATM 5213 N N5 . 3ZJ D 3 . ? 39.999 107.980 9.333 1.00 79.73 ? 1001 3ZJ A N5 1 HETATM 5214 C C6 . 3ZJ D 3 . ? 45.362 105.837 12.550 1.00 64.92 ? 1001 3ZJ A C6 1 HETATM 5215 C C7 . 3ZJ D 3 . ? 40.861 108.952 9.954 1.00 74.07 ? 1001 3ZJ A C7 1 HETATM 5216 C C8 . 3ZJ D 3 . ? 46.513 105.756 11.757 1.00 61.62 ? 1001 3ZJ A C8 1 HETATM 5217 C C9 . 3ZJ D 3 . ? 47.677 105.081 12.224 1.00 58.88 ? 1001 3ZJ A C9 1 HETATM 5218 N N10 . 3ZJ D 3 . ? 42.249 109.808 8.256 1.00 70.68 ? 1001 3ZJ A N10 1 HETATM 5219 O O12 . 3ZJ D 3 . ? 43.327 105.831 11.495 1.00 75.04 ? 1001 3ZJ A O12 1 HETATM 5220 O O19 . 3ZJ D 3 . ? 48.855 104.987 11.444 1.00 51.45 ? 1001 3ZJ A O19 1 HETATM 5221 O O21 . 3ZJ D 3 . ? 48.842 103.803 13.965 1.00 61.67 ? 1001 3ZJ A O21 1 HETATM 5222 O O23 . 3ZJ D 3 . ? 50.602 107.397 8.067 1.00 40.41 ? 1001 3ZJ A O23 1 HETATM 5223 C C31 . 3ZJ D 3 . ? 50.140 106.914 6.787 1.00 39.61 ? 1001 3ZJ A C31 1 HETATM 5224 C C32 . 3ZJ D 3 . ? 35.100 109.824 8.645 1.00 76.94 ? 1001 3ZJ A C32 1 HETATM 5225 C C33 . 3ZJ D 3 . ? 36.922 110.321 7.104 1.00 78.33 ? 1001 3ZJ A C33 1 HETATM 5226 C C34 . 3ZJ D 3 . ? 35.676 110.660 7.676 1.00 77.37 ? 1001 3ZJ A C34 1 HETATM 5227 S S35 . 3ZJ D 3 . ? 38.806 107.264 10.176 1.00 82.83 ? 1001 3ZJ A S35 1 HETATM 5228 O O36 . 3ZJ D 3 . ? 39.353 106.000 10.655 1.00 84.94 ? 1001 3ZJ A O36 1 HETATM 5229 O O37 . 3ZJ D 3 . ? 38.220 108.183 11.142 1.00 76.90 ? 1001 3ZJ A O37 1 HETATM 5230 S S . SO4 E 4 . ? 53.996 97.943 0.013 1.00 81.27 ? 1002 SO4 A S 1 HETATM 5231 O O1 . SO4 E 4 . ? 53.536 99.230 -0.538 1.00 81.19 ? 1002 SO4 A O1 1 HETATM 5232 O O2 . SO4 E 4 . ? 54.683 97.182 -1.008 1.00 78.24 ? 1002 SO4 A O2 1 HETATM 5233 O O3 . SO4 E 4 . ? 54.967 98.169 1.094 1.00 84.37 ? 1002 SO4 A O3 1 HETATM 5234 O O4 . SO4 E 4 . ? 52.838 97.197 0.543 1.00 80.92 ? 1002 SO4 A O4 1 HETATM 5235 C C1 . NAG F 2 . ? 56.547 97.754 -41.063 1.00 110.79 ? 1000 NAG B C1 1 HETATM 5236 C C2 . NAG F 2 . ? 56.042 98.093 -42.467 1.00 114.26 ? 1000 NAG B C2 1 HETATM 5237 C C3 . NAG F 2 . ? 57.228 97.966 -43.423 1.00 115.54 ? 1000 NAG B C3 1 HETATM 5238 C C4 . NAG F 2 . ? 58.370 98.881 -42.990 1.00 115.50 ? 1000 NAG B C4 1 HETATM 5239 C C5 . NAG F 2 . ? 58.748 98.617 -41.533 1.00 115.72 ? 1000 NAG B C5 1 HETATM 5240 C C6 . NAG F 2 . ? 59.744 99.608 -40.973 1.00 116.92 ? 1000 NAG B C6 1 HETATM 5241 C C7 . NAG F 2 . ? 53.666 97.591 -42.923 1.00 116.67 ? 1000 NAG B C7 1 HETATM 5242 C C8 . NAG F 2 . ? 52.720 96.594 -43.523 1.00 117.43 ? 1000 NAG B C8 1 HETATM 5243 N N2 . NAG F 2 . ? 54.957 97.219 -42.884 1.00 115.61 ? 1000 NAG B N2 1 HETATM 5244 O O3 . NAG F 2 . ? 56.810 98.301 -44.741 1.00 115.85 ? 1000 NAG B O3 1 HETATM 5245 O O4 . NAG F 2 . ? 59.507 98.637 -43.813 1.00 115.25 ? 1000 NAG B O4 1 HETATM 5246 O O5 . NAG F 2 . ? 57.575 98.686 -40.700 1.00 114.10 ? 1000 NAG B O5 1 HETATM 5247 O O6 . NAG F 2 . ? 60.951 99.618 -41.732 1.00 117.59 ? 1000 NAG B O6 1 HETATM 5248 O O7 . NAG F 2 . ? 53.283 98.681 -42.504 1.00 116.61 ? 1000 NAG B O7 1 HETATM 5249 C C1 . 3ZJ G 3 . ? 67.342 86.502 -20.471 1.00 71.57 ? 1001 3ZJ B C1 1 HETATM 5250 C C3 . 3ZJ G 3 . ? 67.956 87.923 -22.414 1.00 66.18 ? 1001 3ZJ B C3 1 HETATM 5251 C C11 . 3ZJ G 3 . ? 73.453 86.019 -24.260 1.00 81.45 ? 1001 3ZJ B C11 1 HETATM 5252 C C13 . 3ZJ G 3 . ? 64.871 85.257 -17.138 1.00 66.14 ? 1001 3ZJ B C13 1 HETATM 5253 C C14 . 3ZJ G 3 . ? 65.528 85.010 -19.484 1.00 71.50 ? 1001 3ZJ B C14 1 HETATM 5254 C C15 . 3ZJ G 3 . ? 65.787 88.304 -21.072 1.00 63.43 ? 1001 3ZJ B C15 1 HETATM 5255 C C16 . 3ZJ G 3 . ? 64.729 84.622 -18.396 1.00 69.96 ? 1001 3ZJ B C16 1 HETATM 5256 C C17 . 3ZJ G 3 . ? 69.862 89.418 -21.284 1.00 66.14 ? 1001 3ZJ B C17 1 HETATM 5257 C C18 . 3ZJ G 3 . ? 70.621 89.760 -23.539 1.00 68.99 ? 1001 3ZJ B C18 1 HETATM 5258 C C20 . 3ZJ G 3 . ? 73.822 87.035 -25.367 1.00 82.80 ? 1001 3ZJ B C20 1 HETATM 5259 C C22 . 3ZJ G 3 . ? 66.055 89.386 -15.740 1.00 49.06 ? 1001 3ZJ B C22 1 HETATM 5260 C C24 . 3ZJ G 3 . ? 66.789 88.055 -15.420 1.00 57.28 ? 1001 3ZJ B C24 1 HETATM 5261 C C25 . 3ZJ G 3 . ? 67.014 90.581 -15.665 1.00 46.27 ? 1001 3ZJ B C25 1 HETATM 5262 C C26 . 3ZJ G 3 . ? 65.918 89.806 -20.721 1.00 60.14 ? 1001 3ZJ B C26 1 HETATM 5263 C C27 . 3ZJ G 3 . ? 64.720 88.010 -22.161 1.00 65.49 ? 1001 3ZJ B C27 1 HETATM 5264 C C28 . 3ZJ G 3 . ? 73.969 86.600 -26.700 1.00 84.85 ? 1001 3ZJ B C28 1 HETATM 5265 C C29 . 3ZJ G 3 . ? 74.027 88.414 -25.091 1.00 83.28 ? 1001 3ZJ B C29 1 HETATM 5266 C C30 . 3ZJ G 3 . ? 63.686 83.569 -15.742 1.00 62.60 ? 1001 3ZJ B C30 1 HETATM 5267 N N2 . 3ZJ G 3 . ? 67.065 87.582 -21.278 1.00 65.96 ? 1001 3ZJ B N2 1 HETATM 5268 C C4 . 3ZJ G 3 . ? 69.460 88.176 -22.111 1.00 68.35 ? 1001 3ZJ B C4 1 HETATM 5269 N N5 . 3ZJ G 3 . ? 71.482 87.423 -23.270 1.00 78.89 ? 1001 3ZJ B N5 1 HETATM 5270 C C6 . 3ZJ G 3 . ? 66.452 86.063 -19.323 1.00 71.43 ? 1001 3ZJ B C6 1 HETATM 5271 C C7 . 3ZJ G 3 . ? 70.297 88.264 -23.397 1.00 71.89 ? 1001 3ZJ B C7 1 HETATM 5272 C C8 . 3ZJ G 3 . ? 66.588 86.702 -18.074 1.00 70.14 ? 1001 3ZJ B C8 1 HETATM 5273 C C9 . 3ZJ G 3 . ? 65.792 86.318 -16.968 1.00 67.05 ? 1001 3ZJ B C9 1 HETATM 5274 N N10 . 3ZJ G 3 . ? 70.756 90.215 -22.144 1.00 66.78 ? 1001 3ZJ B N10 1 HETATM 5275 O O12 . 3ZJ G 3 . ? 68.352 85.801 -20.562 1.00 75.96 ? 1001 3ZJ B O12 1 HETATM 5276 O O19 . 3ZJ G 3 . ? 65.920 86.931 -15.701 1.00 63.21 ? 1001 3ZJ B O19 1 HETATM 5277 O O21 . 3ZJ G 3 . ? 64.071 84.913 -16.054 1.00 62.40 ? 1001 3ZJ B O21 1 HETATM 5278 O O23 . 3ZJ G 3 . ? 67.248 90.940 -14.303 1.00 47.97 ? 1001 3ZJ B O23 1 HETATM 5279 C C31 . 3ZJ G 3 . ? 68.656 90.979 -13.987 1.00 46.75 ? 1001 3ZJ B C31 1 HETATM 5280 C C32 . 3ZJ G 3 . ? 74.293 87.519 -27.728 1.00 86.04 ? 1001 3ZJ B C32 1 HETATM 5281 C C33 . 3ZJ G 3 . ? 74.349 89.341 -26.112 1.00 84.29 ? 1001 3ZJ B C33 1 HETATM 5282 C C34 . 3ZJ G 3 . ? 74.474 88.894 -27.442 1.00 85.40 ? 1001 3ZJ B C34 1 HETATM 5283 S S35 . 3ZJ G 3 . ? 71.654 85.998 -24.049 1.00 82.93 ? 1001 3ZJ B S35 1 HETATM 5284 O O36 . 3ZJ G 3 . ? 71.233 84.929 -23.157 1.00 81.36 ? 1001 3ZJ B O36 1 HETATM 5285 O O37 . 3ZJ G 3 . ? 70.987 86.125 -25.345 1.00 86.40 ? 1001 3ZJ B O37 1 HETATM 5286 S S . DMS H 5 . ? 70.340 85.704 -17.268 1.00 92.21 ? 1002 DMS B S 1 HETATM 5287 O O . DMS H 5 . ? 70.779 85.767 -18.690 1.00 92.79 ? 1002 DMS B O 1 HETATM 5288 C C1 . DMS H 5 . ? 69.292 84.281 -17.196 1.00 92.27 ? 1002 DMS B C1 1 HETATM 5289 C C2 . DMS H 5 . ? 71.756 85.084 -16.408 1.00 90.27 ? 1002 DMS B C2 1 HETATM 5290 S S . DMS I 5 . ? 66.602 83.240 -12.750 1.00 112.71 ? 1003 DMS B S 1 HETATM 5291 O O . DMS I 5 . ? 65.333 83.748 -12.162 1.00 111.50 ? 1003 DMS B O 1 HETATM 5292 C C1 . DMS I 5 . ? 66.211 81.737 -13.606 1.00 112.91 ? 1003 DMS B C1 1 HETATM 5293 C C2 . DMS I 5 . ? 66.956 84.250 -14.153 1.00 111.00 ? 1003 DMS B C2 1 HETATM 5294 O O . HOH J 6 . ? 47.404 92.106 -14.226 1.00 40.85 ? 1101 HOH A O 1 HETATM 5295 O O . HOH J 6 . ? 46.687 103.690 26.993 1.00 39.66 ? 1102 HOH A O 1 HETATM 5296 O O . HOH J 6 . ? 37.045 102.459 2.995 1.00 49.88 ? 1103 HOH A O 1 HETATM 5297 O O . HOH J 6 . ? 54.754 110.137 -2.914 1.00 33.20 ? 1104 HOH A O 1 HETATM 5298 O O . HOH J 6 . ? 56.841 125.309 26.641 1.00 41.36 ? 1105 HOH A O 1 HETATM 5299 O O . HOH J 6 . ? 50.826 92.839 -10.469 1.00 42.31 ? 1106 HOH A O 1 HETATM 5300 O O . HOH J 6 . ? 39.930 115.758 30.573 1.00 44.98 ? 1107 HOH A O 1 HETATM 5301 O O . HOH J 6 . ? 62.922 116.424 -15.286 1.00 56.43 ? 1108 HOH A O 1 HETATM 5302 O O . HOH J 6 . ? 62.341 107.605 7.243 1.00 35.43 ? 1109 HOH A O 1 HETATM 5303 O O . HOH J 6 . ? 37.809 111.379 10.869 1.00 75.51 ? 1110 HOH A O 1 HETATM 5304 O O . HOH J 6 . ? 44.699 122.206 8.139 1.00 46.94 ? 1111 HOH A O 1 HETATM 5305 O O . HOH J 6 . ? 56.584 114.362 27.712 1.00 40.58 ? 1112 HOH A O 1 HETATM 5306 O O . HOH J 6 . ? 46.129 122.623 29.740 1.00 39.93 ? 1113 HOH A O 1 HETATM 5307 O O . HOH J 6 . ? 49.027 120.903 29.753 1.00 37.50 ? 1114 HOH A O 1 HETATM 5308 O O . HOH J 6 . ? 42.647 125.108 27.849 1.00 40.45 ? 1115 HOH A O 1 HETATM 5309 O O . HOH J 6 . ? 31.783 119.537 12.264 1.00 57.73 ? 1116 HOH A O 1 HETATM 5310 O O . HOH J 6 . ? 57.591 129.055 29.988 1.00 32.10 ? 1117 HOH A O 1 HETATM 5311 O O . HOH J 6 . ? 56.044 124.873 -6.552 1.00 57.85 ? 1118 HOH A O 1 HETATM 5312 O O . HOH J 6 . ? 42.991 111.186 31.955 1.00 56.91 ? 1119 HOH A O 1 HETATM 5313 O O . HOH J 6 . ? 56.605 116.980 -1.368 1.00 46.68 ? 1120 HOH A O 1 HETATM 5314 O O . HOH J 6 . ? 35.273 114.081 -8.488 1.00 45.17 ? 1121 HOH A O 1 HETATM 5315 O O . HOH J 6 . ? 44.625 126.029 32.138 1.00 49.22 ? 1122 HOH A O 1 HETATM 5316 O O . HOH J 6 . ? 52.947 101.371 -2.449 1.00 40.09 ? 1123 HOH A O 1 HETATM 5317 O O . HOH J 6 . ? 59.664 117.320 10.552 1.00 38.96 ? 1124 HOH A O 1 HETATM 5318 O O . HOH J 6 . ? 39.385 131.256 29.153 1.00 59.86 ? 1125 HOH A O 1 HETATM 5319 O O . HOH J 6 . ? 42.130 122.045 15.535 1.00 61.57 ? 1126 HOH A O 1 HETATM 5320 O O . HOH J 6 . ? 49.290 104.011 -13.446 1.00 49.08 ? 1127 HOH A O 1 HETATM 5321 O O . HOH J 6 . ? 60.923 101.506 9.590 1.00 37.81 ? 1128 HOH A O 1 HETATM 5322 O O . HOH J 6 . ? 49.856 108.576 19.499 1.00 31.19 ? 1129 HOH A O 1 HETATM 5323 O O . HOH J 6 . ? 49.993 121.532 33.521 1.00 50.45 ? 1130 HOH A O 1 HETATM 5324 O O . HOH J 6 . ? 38.806 115.421 3.899 1.00 47.07 ? 1131 HOH A O 1 HETATM 5325 O O . HOH J 6 . ? 47.669 132.838 13.436 1.00 43.40 ? 1132 HOH A O 1 HETATM 5326 O O . HOH J 6 . ? 57.128 109.848 21.832 1.00 48.56 ? 1133 HOH A O 1 HETATM 5327 O O . HOH J 6 . ? 42.035 115.436 13.474 1.00 47.34 ? 1134 HOH A O 1 HETATM 5328 O O . HOH J 6 . ? 33.306 116.902 21.107 1.00 51.20 ? 1135 HOH A O 1 HETATM 5329 O O . HOH J 6 . ? 46.059 101.914 29.609 1.00 38.47 ? 1136 HOH A O 1 HETATM 5330 O O . HOH J 6 . ? 45.253 103.631 9.272 1.00 55.38 ? 1137 HOH A O 1 HETATM 5331 O O . HOH J 6 . ? 49.444 133.631 27.737 1.00 57.22 ? 1138 HOH A O 1 HETATM 5332 O O . HOH J 6 . ? 48.742 109.515 36.745 1.00 60.89 ? 1139 HOH A O 1 HETATM 5333 O O . HOH J 6 . ? 48.190 94.570 9.488 1.00 55.32 ? 1140 HOH A O 1 HETATM 5334 O O . HOH J 6 . ? 36.422 112.928 13.322 1.00 44.39 ? 1141 HOH A O 1 HETATM 5335 O O . HOH J 6 . ? 47.733 102.745 -16.162 1.00 54.59 ? 1142 HOH A O 1 HETATM 5336 O O . HOH J 6 . ? 34.792 105.627 16.991 1.00 64.57 ? 1143 HOH A O 1 HETATM 5337 O O . HOH J 6 . ? 39.003 83.754 3.619 1.00 62.50 ? 1144 HOH A O 1 HETATM 5338 O O . HOH J 6 . ? 60.478 119.795 9.360 1.00 46.85 ? 1145 HOH A O 1 HETATM 5339 O O . HOH J 6 . ? 33.186 121.870 27.765 1.00 51.08 ? 1146 HOH A O 1 HETATM 5340 O O . HOH J 6 . ? 51.765 112.383 7.671 1.00 31.91 ? 1147 HOH A O 1 HETATM 5341 O O . HOH J 6 . ? 38.413 115.984 12.093 1.00 41.21 ? 1148 HOH A O 1 HETATM 5342 O O . HOH J 6 . ? 42.454 127.791 15.487 1.00 41.46 ? 1149 HOH A O 1 HETATM 5343 O O . HOH J 6 . ? 60.528 122.467 25.658 1.00 39.64 ? 1150 HOH A O 1 HETATM 5344 O O . HOH J 6 . ? 43.054 122.196 3.899 1.00 44.42 ? 1151 HOH A O 1 HETATM 5345 O O . HOH J 6 . ? 43.761 121.416 11.576 1.00 45.75 ? 1152 HOH A O 1 HETATM 5346 O O . HOH J 6 . ? 54.384 103.692 21.461 1.00 54.75 ? 1153 HOH A O 1 HETATM 5347 O O . HOH J 6 . ? 54.009 90.412 5.238 1.00 47.37 ? 1154 HOH A O 1 HETATM 5348 O O . HOH J 6 . ? 31.204 110.754 8.249 1.00 48.58 ? 1155 HOH A O 1 HETATM 5349 O O . HOH J 6 . ? 56.260 126.761 19.290 1.00 47.42 ? 1156 HOH A O 1 HETATM 5350 O O . HOH J 6 . ? 59.036 122.253 14.270 1.00 61.85 ? 1157 HOH A O 1 HETATM 5351 O O . HOH J 6 . ? 49.315 132.281 3.038 1.00 56.00 ? 1158 HOH A O 1 HETATM 5352 O O . HOH J 6 . ? 52.233 115.652 34.126 1.00 54.07 ? 1159 HOH A O 1 HETATM 5353 O O . HOH J 6 . ? 56.086 106.201 -8.241 1.00 54.90 ? 1160 HOH A O 1 HETATM 5354 O O . HOH J 6 . ? 63.764 116.860 -0.578 1.00 48.06 ? 1161 HOH A O 1 HETATM 5355 O O . HOH J 6 . ? 34.870 121.647 -7.334 1.00 55.71 ? 1162 HOH A O 1 HETATM 5356 O O . HOH J 6 . ? 32.713 116.397 23.718 1.00 58.94 ? 1163 HOH A O 1 HETATM 5357 O O . HOH J 6 . ? 46.886 99.524 28.860 1.00 49.87 ? 1164 HOH A O 1 HETATM 5358 O O . HOH J 6 . ? 65.062 115.460 -10.444 1.00 53.96 ? 1165 HOH A O 1 HETATM 5359 O O . HOH J 6 . ? 41.368 117.304 32.812 1.00 59.12 ? 1166 HOH A O 1 HETATM 5360 O O . HOH J 6 . ? 44.069 102.101 27.801 1.00 34.00 ? 1167 HOH A O 1 HETATM 5361 O O . HOH J 6 . ? 44.748 102.136 6.820 1.00 55.78 ? 1168 HOH A O 1 HETATM 5362 O O . HOH J 6 . ? 30.609 114.249 21.958 1.00 64.41 ? 1169 HOH A O 1 HETATM 5363 O O . HOH J 6 . ? 48.365 131.828 21.924 1.00 49.73 ? 1170 HOH A O 1 HETATM 5364 O O . HOH J 6 . ? 58.057 109.008 24.992 1.00 70.94 ? 1171 HOH A O 1 HETATM 5365 O O . HOH J 6 . ? 48.749 102.153 10.976 1.00 52.74 ? 1172 HOH A O 1 HETATM 5366 O O . HOH J 6 . ? 60.661 120.261 15.173 1.00 63.17 ? 1173 HOH A O 1 HETATM 5367 O O . HOH J 6 . ? 52.722 135.222 29.191 1.00 49.90 ? 1174 HOH A O 1 HETATM 5368 O O . HOH J 6 . ? 34.648 110.502 28.449 1.00 58.52 ? 1175 HOH A O 1 HETATM 5369 O O . HOH K 6 . ? 72.147 87.785 -8.846 1.00 35.27 ? 1101 HOH B O 1 HETATM 5370 O O . HOH K 6 . ? 55.280 83.572 -13.884 1.00 49.99 ? 1102 HOH B O 1 HETATM 5371 O O . HOH K 6 . ? 72.604 72.803 -7.713 1.00 39.96 ? 1103 HOH B O 1 HETATM 5372 O O . HOH K 6 . ? 46.352 97.909 -16.991 1.00 45.87 ? 1104 HOH B O 1 HETATM 5373 O O . HOH K 6 . ? 88.657 103.528 -21.790 1.00 37.33 ? 1105 HOH B O 1 HETATM 5374 O O . HOH K 6 . ? 72.147 72.965 1.888 1.00 39.67 ? 1106 HOH B O 1 HETATM 5375 O O . HOH K 6 . ? 86.368 88.283 -0.232 1.00 39.55 ? 1107 HOH B O 1 HETATM 5376 O O . HOH K 6 . ? 73.396 99.458 -8.417 1.00 38.75 ? 1108 HOH B O 1 HETATM 5377 O O . HOH K 6 . ? 91.892 100.856 -8.816 1.00 48.60 ? 1109 HOH B O 1 HETATM 5378 O O . HOH K 6 . ? 66.680 101.473 -26.361 1.00 47.16 ? 1110 HOH B O 1 HETATM 5379 O O . HOH K 6 . ? 58.444 104.624 -11.226 1.00 43.35 ? 1111 HOH B O 1 HETATM 5380 O O . HOH K 6 . ? 87.322 99.266 -23.674 1.00 35.26 ? 1112 HOH B O 1 HETATM 5381 O O . HOH K 6 . ? 57.050 103.853 -16.577 1.00 45.51 ? 1113 HOH B O 1 HETATM 5382 O O . HOH K 6 . ? 57.694 109.967 -30.368 1.00 39.53 ? 1114 HOH B O 1 HETATM 5383 O O . HOH K 6 . ? 91.290 88.540 -0.834 1.00 55.32 ? 1115 HOH B O 1 HETATM 5384 O O . HOH K 6 . ? 71.609 102.566 -31.877 1.00 44.00 ? 1116 HOH B O 1 HETATM 5385 O O . HOH K 6 . ? 77.483 77.421 -14.137 1.00 35.47 ? 1117 HOH B O 1 HETATM 5386 O O . HOH K 6 . ? 69.249 105.157 -11.019 1.00 37.14 ? 1118 HOH B O 1 HETATM 5387 O O . HOH K 6 . ? 78.257 99.170 -3.500 1.00 37.64 ? 1119 HOH B O 1 HETATM 5388 O O . HOH K 6 . ? 51.901 92.846 -15.471 1.00 40.30 ? 1120 HOH B O 1 HETATM 5389 O O . HOH K 6 . ? 86.892 98.049 -6.521 1.00 37.97 ? 1121 HOH B O 1 HETATM 5390 O O . HOH K 6 . ? 86.003 108.391 -21.673 1.00 39.82 ? 1122 HOH B O 1 HETATM 5391 O O . HOH K 6 . ? 64.106 98.869 -27.935 1.00 38.04 ? 1123 HOH B O 1 HETATM 5392 O O . HOH K 6 . ? 73.423 87.137 0.689 1.00 39.34 ? 1124 HOH B O 1 HETATM 5393 O O . HOH K 6 . ? 80.635 111.488 -11.337 1.00 53.04 ? 1125 HOH B O 1 HETATM 5394 O O . HOH K 6 . ? 73.434 96.508 -28.493 1.00 39.65 ? 1126 HOH B O 1 HETATM 5395 O O . HOH K 6 . ? 86.794 109.530 -11.972 1.00 60.10 ? 1127 HOH B O 1 HETATM 5396 O O . HOH K 6 . ? 46.109 100.145 -37.999 1.00 62.66 ? 1128 HOH B O 1 HETATM 5397 O O . HOH K 6 . ? 90.391 91.169 -25.964 1.00 69.36 ? 1129 HOH B O 1 HETATM 5398 O O . HOH K 6 . ? 38.523 94.217 -25.993 1.00 66.72 ? 1130 HOH B O 1 HETATM 5399 O O . HOH K 6 . ? 92.395 92.555 -12.350 1.00 49.51 ? 1131 HOH B O 1 HETATM 5400 O O . HOH K 6 . ? 74.719 95.763 -26.211 1.00 37.33 ? 1132 HOH B O 1 HETATM 5401 O O . HOH K 6 . ? 39.407 91.888 -27.741 1.00 76.85 ? 1133 HOH B O 1 HETATM 5402 O O . HOH K 6 . ? 77.015 112.378 -14.619 1.00 68.36 ? 1134 HOH B O 1 HETATM 5403 O O . HOH K 6 . ? 73.204 98.285 -4.881 1.00 45.01 ? 1135 HOH B O 1 HETATM 5404 O O . HOH K 6 . ? 63.449 97.958 -31.478 1.00 62.32 ? 1136 HOH B O 1 HETATM 5405 O O . HOH K 6 . ? 77.243 79.073 -9.691 1.00 50.28 ? 1137 HOH B O 1 HETATM 5406 O O . HOH K 6 . ? 84.424 104.556 -28.210 1.00 56.71 ? 1138 HOH B O 1 HETATM 5407 O O . HOH K 6 . ? 78.100 112.219 -11.640 1.00 48.77 ? 1139 HOH B O 1 HETATM 5408 O O . HOH K 6 . ? 71.453 89.913 -28.568 1.00 52.25 ? 1140 HOH B O 1 HETATM 5409 O O . HOH K 6 . ? 96.698 85.055 -5.004 1.00 68.18 ? 1141 HOH B O 1 HETATM 5410 O O . HOH K 6 . ? 50.476 95.029 -36.164 1.00 62.35 ? 1142 HOH B O 1 HETATM 5411 O O . HOH K 6 . ? 65.792 95.709 -15.607 1.00 46.10 ? 1143 HOH B O 1 HETATM 5412 O O . HOH K 6 . ? 68.548 88.616 -30.245 1.00 59.28 ? 1144 HOH B O 1 HETATM 5413 O O . HOH K 6 . ? 76.084 104.089 -33.008 1.00 53.33 ? 1145 HOH B O 1 HETATM 5414 O O . HOH K 6 . ? 73.360 87.847 4.050 1.00 49.57 ? 1146 HOH B O 1 HETATM 5415 O O . HOH K 6 . ? 73.614 103.177 -33.614 1.00 43.39 ? 1147 HOH B O 1 HETATM 5416 O O . HOH K 6 . ? 71.116 70.564 6.488 1.00 55.82 ? 1148 HOH B O 1 HETATM 5417 O O . HOH K 6 . ? 64.871 106.387 -5.748 1.00 51.73 ? 1149 HOH B O 1 HETATM 5418 O O . HOH K 6 . ? 61.893 95.066 -4.955 1.00 44.73 ? 1150 HOH B O 1 HETATM 5419 O O . HOH K 6 . ? 86.481 87.290 -23.834 1.00 58.06 ? 1151 HOH B O 1 HETATM 5420 O O . HOH K 6 . ? 51.343 104.629 -23.384 1.00 46.92 ? 1152 HOH B O 1 HETATM 5421 O O . HOH K 6 . ? 96.072 83.474 -8.957 1.00 57.65 ? 1153 HOH B O 1 HETATM 5422 O O . HOH K 6 . ? 54.373 105.072 -16.712 1.00 63.87 ? 1154 HOH B O 1 HETATM 5423 O O . HOH K 6 . ? 59.353 79.648 -29.021 1.00 64.23 ? 1155 HOH B O 1 HETATM 5424 O O . HOH K 6 . ? 91.248 90.872 -5.914 1.00 56.71 ? 1156 HOH B O 1 HETATM 5425 O O . HOH K 6 . ? 79.801 86.468 2.628 1.00 60.72 ? 1157 HOH B O 1 HETATM 5426 O O . HOH K 6 . ? 81.042 75.242 -24.079 1.00 69.29 ? 1158 HOH B O 1 HETATM 5427 O O . HOH K 6 . ? 59.728 106.984 -10.728 1.00 51.81 ? 1159 HOH B O 1 HETATM 5428 O O . HOH K 6 . ? 82.959 105.519 -6.726 1.00 47.68 ? 1160 HOH B O 1 HETATM 5429 O O . HOH K 6 . ? 70.934 102.740 -26.169 1.00 40.78 ? 1161 HOH B O 1 HETATM 5430 O O . HOH K 6 . ? 56.432 103.528 -9.664 1.00 50.22 ? 1162 HOH B O 1 HETATM 5431 O O . HOH K 6 . ? 47.035 85.982 -19.684 1.00 65.78 ? 1163 HOH B O 1 HETATM 5432 O O . HOH K 6 . ? 89.612 79.995 -21.224 1.00 64.50 ? 1164 HOH B O 1 HETATM 5433 O O . HOH K 6 . ? 81.987 107.863 -30.018 1.00 53.71 ? 1165 HOH B O 1 HETATM 5434 O O . HOH K 6 . ? 85.665 73.401 -9.091 1.00 68.49 ? 1166 HOH B O 1 HETATM 5435 O O . HOH K 6 . ? 69.839 89.011 -26.713 1.00 59.43 ? 1167 HOH B O 1 HETATM 5436 O O . HOH K 6 . ? 79.863 110.773 -1.950 1.00 60.14 ? 1168 HOH B O 1 HETATM 5437 O O . HOH K 6 . ? 42.712 90.993 -30.068 1.00 79.40 ? 1169 HOH B O 1 HETATM 5438 O O . HOH K 6 . ? 73.215 109.048 -30.152 1.00 59.21 ? 1170 HOH B O 1 HETATM 5439 O O . HOH K 6 . ? 58.008 100.880 -12.327 1.00 50.11 ? 1171 HOH B O 1 HETATM 5440 O O . HOH K 6 . ? 63.353 94.759 -2.662 1.00 55.77 ? 1172 HOH B O 1 HETATM 5441 O O . HOH K 6 . ? 78.379 111.604 -5.743 1.00 49.43 ? 1173 HOH B O 1 HETATM 5442 O O . HOH K 6 . ? 91.361 92.745 -3.129 1.00 50.17 ? 1174 HOH B O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 LEU 1 -5 ? ? ? A . n A 1 2 THR 2 -4 -4 THR THR A . n A 1 3 LEU 3 -3 -3 LEU LEU A . n A 1 4 GLY 4 -2 -2 GLY GLY A . n A 1 5 ASN 5 -1 -1 ASN ASN A . n A 1 6 THR 6 0 0 THR THR A . n A 1 7 THR 7 1 1 THR THR A . n A 1 8 SER 8 2 2 SER SER A . n A 1 9 SER 9 3 3 SER SER A . n A 1 10 VAL 10 4 4 VAL VAL A . n A 1 11 ILE 11 5 5 ILE ILE A . n A 1 12 LEU 12 6 6 LEU LEU A . n A 1 13 THR 13 7 7 THR THR A . n A 1 14 ASN 14 8 8 ASN ASN A . n A 1 15 TYR 15 9 9 TYR TYR A . n A 1 16 MET 16 10 10 MET MET A . n A 1 17 ASP 17 11 11 ASP ASP A . n A 1 18 THR 18 12 12 THR THR A . n A 1 19 GLN 19 13 13 GLN GLN A . n A 1 20 TYR 20 14 14 TYR TYR A . n A 1 21 TYR 21 15 15 TYR TYR A . n A 1 22 GLY 22 16 16 GLY GLY A . n A 1 23 GLU 23 17 17 GLU GLU A . n A 1 24 ILE 24 18 18 ILE ILE A . n A 1 25 GLY 25 19 19 GLY GLY A . n A 1 26 ILE 26 20 20 ILE ILE A . n A 1 27 GLY 27 21 21 GLY GLY A . n A 1 28 THR 28 22 22 THR THR A . n A 1 29 PRO 29 23 23 PRO PRO A . n A 1 30 PRO 30 24 24 PRO PRO A . n A 1 31 GLN 31 25 25 GLN GLN A . n A 1 32 THR 32 26 26 THR THR A . n A 1 33 PHE 33 27 27 PHE PHE A . n A 1 34 LYS 34 28 28 LYS LYS A . n A 1 35 VAL 35 29 29 VAL VAL A . n A 1 36 VAL 36 30 30 VAL VAL A . n A 1 37 PHE 37 31 31 PHE PHE A . n A 1 38 ASP 38 32 32 ASP ASP A . n A 1 39 THR 39 33 33 THR THR A . n A 1 40 GLY 40 34 34 GLY GLY A . n A 1 41 SER 41 35 35 SER SER A . n A 1 42 SER 42 36 36 SER SER A . n A 1 43 ASN 43 37 37 ASN ASN A . n A 1 44 VAL 44 38 38 VAL VAL A . n A 1 45 TRP 45 39 39 TRP TRP A . n A 1 46 VAL 46 40 40 VAL VAL A . n A 1 47 PRO 47 41 41 PRO PRO A . n A 1 48 SER 48 42 42 SER SER A . n A 1 49 SER 49 43 43 SER SER A . n A 1 50 LYS 50 44 44 LYS LYS A . n A 1 51 CYS 51 45 45 CYS CYS A . n A 1 52 SER 52 46 46 SER SER A . n A 1 53 ARG 53 47 47 ARG ARG A . n A 1 54 LEU 54 47 47 LEU LEU A A n A 1 55 TYR 55 47 47 TYR TYR A B n A 1 56 THR 56 48 48 THR THR A . n A 1 57 ALA 57 49 49 ALA ALA A . n A 1 58 CYS 58 50 50 CYS CYS A . n A 1 59 VAL 59 51 51 VAL VAL A . n A 1 60 TYR 60 52 52 TYR TYR A . n A 1 61 HIS 61 53 53 HIS HIS A . n A 1 62 LYS 62 54 54 LYS LYS A . n A 1 63 LEU 63 55 55 LEU LEU A . n A 1 64 PHE 64 56 56 PHE PHE A . n A 1 65 ASP 65 57 57 ASP ASP A . n A 1 66 ALA 66 58 58 ALA ALA A . n A 1 67 SER 67 59 59 SER SER A . n A 1 68 ASP 68 60 60 ASP ASP A . n A 1 69 SER 69 61 61 SER SER A . n A 1 70 SER 70 62 62 SER SER A . n A 1 71 SER 71 63 63 SER SER A . n A 1 72 TYR 72 64 64 TYR TYR A . n A 1 73 LYS 73 65 65 LYS LYS A . n A 1 74 HIS 74 66 66 HIS HIS A . n A 1 75 ASN 75 67 67 ASN ASN A . n A 1 76 GLY 76 68 68 GLY GLY A . n A 1 77 THR 77 69 69 THR THR A . n A 1 78 GLU 78 70 70 GLU GLU A . n A 1 79 LEU 79 71 71 LEU LEU A . n A 1 80 THR 80 72 72 THR THR A . n A 1 81 LEU 81 73 73 LEU LEU A . n A 1 82 ARG 82 74 74 ARG ARG A . n A 1 83 TYR 83 75 75 TYR TYR A . n A 1 84 SER 84 76 76 SER SER A . n A 1 85 THR 85 77 77 THR THR A . n A 1 86 GLY 86 78 78 GLY GLY A . n A 1 87 THR 87 79 79 THR THR A . n A 1 88 VAL 88 80 80 VAL VAL A . n A 1 89 SER 89 81 81 SER SER A . n A 1 90 GLY 90 82 82 GLY GLY A . n A 1 91 PHE 91 83 83 PHE PHE A . n A 1 92 LEU 92 84 84 LEU LEU A . n A 1 93 SER 93 85 85 SER SER A . n A 1 94 GLN 94 86 86 GLN GLN A . n A 1 95 ASP 95 87 87 ASP ASP A . n A 1 96 ILE 96 88 88 ILE ILE A . n A 1 97 ILE 97 89 89 ILE ILE A . n A 1 98 THR 98 90 90 THR THR A . n A 1 99 VAL 99 91 91 VAL VAL A . n A 1 100 GLY 100 92 92 GLY GLY A . n A 1 101 GLY 101 93 93 GLY GLY A . n A 1 102 ILE 102 94 94 ILE ILE A . n A 1 103 THR 103 95 95 THR THR A . n A 1 104 VAL 104 96 96 VAL VAL A . n A 1 105 THR 105 97 97 THR THR A . n A 1 106 GLN 106 99 99 GLN GLN A . n A 1 107 MET 107 100 100 MET MET A . n A 1 108 PHE 108 101 101 PHE PHE A . n A 1 109 GLY 109 102 102 GLY GLY A . n A 1 110 GLU 110 103 103 GLU GLU A . n A 1 111 VAL 111 104 104 VAL VAL A . n A 1 112 THR 112 105 105 THR THR A . n A 1 113 GLU 113 106 106 GLU GLU A . n A 1 114 MET 114 107 107 MET MET A . n A 1 115 PRO 115 108 108 PRO PRO A . n A 1 116 ALA 116 109 109 ALA ALA A . n A 1 117 LEU 117 110 110 LEU LEU A . n A 1 118 PRO 118 111 111 PRO PRO A . n A 1 119 PHE 119 112 112 PHE PHE A . n A 1 120 MET 120 113 113 MET MET A . n A 1 121 LEU 121 114 114 LEU LEU A . n A 1 122 ALA 122 115 115 ALA ALA A . n A 1 123 GLU 123 116 116 GLU GLU A . n A 1 124 PHE 124 117 117 PHE PHE A . n A 1 125 ASP 125 118 118 ASP ASP A . n A 1 126 GLY 126 119 119 GLY GLY A . n A 1 127 VAL 127 120 120 VAL VAL A . n A 1 128 VAL 128 121 121 VAL VAL A . n A 1 129 GLY 129 122 122 GLY GLY A . n A 1 130 MET 130 123 123 MET MET A . n A 1 131 GLY 131 124 124 GLY GLY A . n A 1 132 PHE 132 125 125 PHE PHE A . n A 1 133 ILE 133 126 126 ILE ILE A . n A 1 134 GLU 134 127 127 GLU GLU A . n A 1 135 GLN 135 128 128 GLN GLN A . n A 1 136 ALA 136 129 129 ALA ALA A . n A 1 137 ILE 137 130 130 ILE ILE A . n A 1 138 GLY 138 131 131 GLY GLY A . n A 1 139 ARG 139 132 132 ARG ARG A . n A 1 140 VAL 140 133 133 VAL VAL A . n A 1 141 THR 141 134 134 THR THR A . n A 1 142 PRO 142 135 135 PRO PRO A . n A 1 143 ILE 143 136 136 ILE ILE A . n A 1 144 PHE 144 137 137 PHE PHE A . n A 1 145 ASP 145 138 138 ASP ASP A . n A 1 146 ASN 146 139 139 ASN ASN A . n A 1 147 ILE 147 140 140 ILE ILE A . n A 1 148 ILE 148 141 141 ILE ILE A . n A 1 149 SER 149 142 142 SER SER A . n A 1 150 GLN 150 143 143 GLN GLN A . n A 1 151 GLY 151 144 144 GLY GLY A . n A 1 152 VAL 152 145 145 VAL VAL A . n A 1 153 LEU 153 146 146 LEU LEU A . n A 1 154 LYS 154 147 147 LYS LYS A . n A 1 155 GLU 155 148 148 GLU GLU A . n A 1 156 ASP 156 149 149 ASP ASP A . n A 1 157 VAL 157 150 150 VAL VAL A . n A 1 158 PHE 158 151 151 PHE PHE A . n A 1 159 SER 159 152 152 SER SER A . n A 1 160 PHE 160 153 153 PHE PHE A . n A 1 161 TYR 161 154 154 TYR TYR A . n A 1 162 TYR 162 155 155 TYR TYR A . n A 1 163 ASN 163 156 156 ASN ASN A . n A 1 164 ARG 164 157 157 ARG ARG A . n A 1 165 ASP 165 158 158 ASP ASP A . n A 1 166 SER 166 159 159 SER SER A . n A 1 167 GLU 167 159 ? ? ? A A n A 1 168 ASN 168 159 ? ? ? A B n A 1 169 SER 169 159 ? ? ? A C n A 1 170 GLN 170 160 160 GLN GLN A C n A 1 171 SER 171 160 160 SER SER A D n A 1 172 LEU 172 161 161 LEU LEU A . n A 1 173 GLY 173 162 162 GLY GLY A . n A 1 174 GLY 174 163 163 GLY GLY A . n A 1 175 GLN 175 164 164 GLN GLN A . n A 1 176 ILE 176 165 165 ILE ILE A . n A 1 177 VAL 177 166 166 VAL VAL A . n A 1 178 LEU 178 167 167 LEU LEU A . n A 1 179 GLY 179 168 168 GLY GLY A . n A 1 180 GLY 180 169 169 GLY GLY A . n A 1 181 SER 181 170 170 SER SER A . n A 1 182 ASP 182 171 171 ASP ASP A . n A 1 183 PRO 183 172 172 PRO PRO A . n A 1 184 GLN 184 173 173 GLN GLN A . n A 1 185 HIS 185 174 174 HIS HIS A . n A 1 186 TYR 186 175 175 TYR TYR A . n A 1 187 GLU 187 176 176 GLU GLU A . n A 1 188 GLY 188 177 177 GLY GLY A . n A 1 189 ASN 189 178 178 ASN ASN A . n A 1 190 PHE 190 179 179 PHE PHE A . n A 1 191 HIS 191 180 180 HIS HIS A . n A 1 192 TYR 192 181 181 TYR TYR A . n A 1 193 ILE 193 182 182 ILE ILE A . n A 1 194 ASN 194 183 183 ASN ASN A . n A 1 195 LEU 195 184 184 LEU LEU A . n A 1 196 ILE 196 185 185 ILE ILE A . n A 1 197 LYS 197 186 186 LYS LYS A . n A 1 198 THR 198 187 187 THR THR A . n A 1 199 GLY 199 188 188 GLY GLY A . n A 1 200 VAL 200 189 189 VAL VAL A . n A 1 201 TRP 201 190 190 TRP TRP A . n A 1 202 GLN 202 191 191 GLN GLN A . n A 1 203 ILE 203 192 192 ILE ILE A . n A 1 204 GLN 204 193 193 GLN GLN A . n A 1 205 MET 205 194 194 MET MET A . n A 1 206 LYS 206 195 195 LYS LYS A . n A 1 207 GLY 207 196 196 GLY GLY A . n A 1 208 VAL 208 197 197 VAL VAL A . n A 1 209 SER 209 198 198 SER SER A . n A 1 210 VAL 210 199 199 VAL VAL A . n A 1 211 GLY 211 200 200 GLY GLY A . n A 1 212 SER 212 201 201 SER SER A . n A 1 213 SER 213 202 202 SER SER A . n A 1 214 THR 214 203 203 THR THR A . n A 1 215 LEU 215 204 204 LEU LEU A . n A 1 216 LEU 216 205 205 LEU LEU A . n A 1 217 CYS 217 206 206 CYS CYS A . n A 1 218 GLU 218 207 207 GLU GLU A . n A 1 219 ASP 219 208 208 ASP ASP A . n A 1 220 GLY 220 209 209 GLY GLY A . n A 1 221 CYS 221 210 210 CYS CYS A . n A 1 222 LEU 222 211 211 LEU LEU A . n A 1 223 ALA 223 212 212 ALA ALA A . n A 1 224 LEU 224 213 213 LEU LEU A . n A 1 225 VAL 225 214 214 VAL VAL A . n A 1 226 ASP 226 215 215 ASP ASP A . n A 1 227 THR 227 216 216 THR THR A . n A 1 228 GLY 228 217 217 GLY GLY A . n A 1 229 ALA 229 218 218 ALA ALA A . n A 1 230 SER 230 219 219 SER SER A . n A 1 231 TYR 231 220 220 TYR TYR A . n A 1 232 ILE 232 221 221 ILE ILE A . n A 1 233 SER 233 222 222 SER SER A . n A 1 234 GLY 234 223 223 GLY GLY A . n A 1 235 SER 235 224 224 SER SER A . n A 1 236 THR 236 225 225 THR THR A . n A 1 237 SER 237 226 226 SER SER A . n A 1 238 SER 238 227 227 SER SER A . n A 1 239 ILE 239 228 228 ILE ILE A . n A 1 240 GLU 240 229 229 GLU GLU A . n A 1 241 LYS 241 230 230 LYS LYS A . n A 1 242 LEU 242 231 231 LEU LEU A . n A 1 243 MET 243 232 232 MET MET A . n A 1 244 GLU 244 233 233 GLU GLU A . n A 1 245 ALA 245 234 234 ALA ALA A . n A 1 246 LEU 246 235 235 LEU LEU A . n A 1 247 GLY 247 236 236 GLY GLY A . n A 1 248 ALA 248 237 237 ALA ALA A . n A 1 249 LYS 249 238 238 LYS LYS A . n A 1 250 LYS 250 239 239 LYS LYS A . n A 1 251 ARG 251 240 240 ARG ARG A . n A 1 252 LEU 252 241 241 LEU LEU A . n A 1 253 PHE 253 242 242 PHE PHE A . n A 1 254 ASP 254 244 244 ASP ASP A . n A 1 255 TYR 255 245 245 TYR TYR A . n A 1 256 VAL 256 246 246 VAL VAL A . n A 1 257 VAL 257 247 247 VAL VAL A . n A 1 258 LYS 258 248 248 LYS LYS A . n A 1 259 CYS 259 249 249 CYS CYS A . n A 1 260 ASN 260 250 250 ASN ASN A . n A 1 261 GLU 261 251 251 GLU GLU A . n A 1 262 GLY 262 252 252 GLY GLY A . n A 1 263 PRO 263 253 253 PRO PRO A . n A 1 264 THR 264 254 254 THR THR A . n A 1 265 LEU 265 255 255 LEU LEU A . n A 1 266 PRO 266 256 256 PRO PRO A . n A 1 267 ASP 267 257 257 ASP ASP A . n A 1 268 ILE 268 258 258 ILE ILE A . n A 1 269 SER 269 259 259 SER SER A . n A 1 270 PHE 270 260 260 PHE PHE A . n A 1 271 HIS 271 261 261 HIS HIS A . n A 1 272 LEU 272 262 262 LEU LEU A . n A 1 273 GLY 273 263 263 GLY GLY A . n A 1 274 GLY 274 264 264 GLY GLY A . n A 1 275 LYS 275 265 265 LYS LYS A . n A 1 276 GLU 276 266 266 GLU GLU A . n A 1 277 TYR 277 267 267 TYR TYR A . n A 1 278 THR 278 268 268 THR THR A . n A 1 279 LEU 279 269 269 LEU LEU A . n A 1 280 THR 280 270 270 THR THR A . n A 1 281 SER 281 271 271 SER SER A . n A 1 282 ALA 282 272 272 ALA ALA A . n A 1 283 ASP 283 273 273 ASP ASP A . n A 1 284 TYR 284 274 274 TYR TYR A . n A 1 285 VAL 285 275 275 VAL VAL A . n A 1 286 PHE 286 276 276 PHE PHE A . n A 1 287 GLN 287 277 277 GLN GLN A . n A 1 288 GLU 288 278 278 GLU GLU A . n A 1 289 SER 289 279 279 SER SER A . n A 1 290 TYR 290 280 280 TYR TYR A . n A 1 291 SER 291 281 281 SER SER A . n A 1 292 SER 292 281 281 SER SER A A n A 1 293 LYS 293 281 281 LYS LYS A B n A 1 294 LYS 294 281 281 LYS LYS A C n A 1 295 LEU 295 281 281 LEU LEU A D n A 1 296 CYS 296 282 282 CYS CYS A . n A 1 297 THR 297 283 283 THR THR A . n A 1 298 LEU 298 284 284 LEU LEU A . n A 1 299 ALA 299 285 285 ALA ALA A . n A 1 300 ILE 300 286 286 ILE ILE A . n A 1 301 HIS 301 287 287 HIS HIS A . n A 1 302 ALA 302 288 288 ALA ALA A . n A 1 303 MET 303 289 289 MET MET A . n A 1 304 ASP 304 290 290 ASP ASP A . n A 1 305 ILE 305 291 291 ILE ILE A . n A 1 306 PRO 306 292 292 PRO PRO A . n A 1 307 PRO 307 293 293 PRO PRO A . n A 1 308 PRO 308 294 294 PRO PRO A . n A 1 309 THR 309 295 295 THR THR A . n A 1 310 GLY 310 296 296 GLY GLY A . n A 1 311 PRO 311 297 297 PRO PRO A . n A 1 312 THR 312 298 298 THR THR A . n A 1 313 TRP 313 299 299 TRP TRP A . n A 1 314 ALA 314 300 300 ALA ALA A . n A 1 315 LEU 315 301 301 LEU LEU A . n A 1 316 GLY 316 302 302 GLY GLY A . n A 1 317 ALA 317 303 303 ALA ALA A . n A 1 318 THR 318 304 304 THR THR A . n A 1 319 PHE 319 305 305 PHE PHE A . n A 1 320 ILE 320 306 306 ILE ILE A . n A 1 321 ARG 321 307 307 ARG ARG A . n A 1 322 LYS 322 308 308 LYS LYS A . n A 1 323 PHE 323 309 309 PHE PHE A . n A 1 324 TYR 324 310 310 TYR TYR A . n A 1 325 THR 325 311 311 THR THR A . n A 1 326 GLU 326 312 312 GLU GLU A . n A 1 327 PHE 327 313 313 PHE PHE A . n A 1 328 ASP 328 314 314 ASP ASP A . n A 1 329 ARG 329 315 315 ARG ARG A . n A 1 330 ARG 330 316 316 ARG ARG A . n A 1 331 ASN 331 317 317 ASN ASN A . n A 1 332 ASN 332 318 318 ASN ASN A . n A 1 333 ARG 333 319 319 ARG ARG A . n A 1 334 ILE 334 320 320 ILE ILE A . n A 1 335 GLY 335 321 321 GLY GLY A . n A 1 336 PHE 336 322 322 PHE PHE A . n A 1 337 ALA 337 323 323 ALA ALA A . n A 1 338 LEU 338 324 324 LEU LEU A . n A 1 339 ALA 339 325 325 ALA ALA A . n A 1 340 ARG 340 326 326 ARG ARG A . n B 1 1 LEU 1 -5 -5 LEU LEU B . n B 1 2 THR 2 -4 -4 THR THR B . n B 1 3 LEU 3 -3 -3 LEU LEU B . n B 1 4 GLY 4 -2 -2 GLY GLY B . n B 1 5 ASN 5 -1 -1 ASN ASN B . n B 1 6 THR 6 0 0 THR THR B . n B 1 7 THR 7 1 1 THR THR B . n B 1 8 SER 8 2 2 SER SER B . n B 1 9 SER 9 3 3 SER SER B . n B 1 10 VAL 10 4 4 VAL VAL B . n B 1 11 ILE 11 5 5 ILE ILE B . n B 1 12 LEU 12 6 6 LEU LEU B . n B 1 13 THR 13 7 7 THR THR B . n B 1 14 ASN 14 8 8 ASN ASN B . n B 1 15 TYR 15 9 9 TYR TYR B . n B 1 16 MET 16 10 10 MET MET B . n B 1 17 ASP 17 11 11 ASP ASP B . n B 1 18 THR 18 12 12 THR THR B . n B 1 19 GLN 19 13 13 GLN GLN B . n B 1 20 TYR 20 14 14 TYR TYR B . n B 1 21 TYR 21 15 15 TYR TYR B . n B 1 22 GLY 22 16 16 GLY GLY B . n B 1 23 GLU 23 17 17 GLU GLU B . n B 1 24 ILE 24 18 18 ILE ILE B . n B 1 25 GLY 25 19 19 GLY GLY B . n B 1 26 ILE 26 20 20 ILE ILE B . n B 1 27 GLY 27 21 21 GLY GLY B . n B 1 28 THR 28 22 22 THR THR B . n B 1 29 PRO 29 23 23 PRO PRO B . n B 1 30 PRO 30 24 24 PRO PRO B . n B 1 31 GLN 31 25 25 GLN GLN B . n B 1 32 THR 32 26 26 THR THR B . n B 1 33 PHE 33 27 27 PHE PHE B . n B 1 34 LYS 34 28 28 LYS LYS B . n B 1 35 VAL 35 29 29 VAL VAL B . n B 1 36 VAL 36 30 30 VAL VAL B . n B 1 37 PHE 37 31 31 PHE PHE B . n B 1 38 ASP 38 32 32 ASP ASP B . n B 1 39 THR 39 33 33 THR THR B . n B 1 40 GLY 40 34 34 GLY GLY B . n B 1 41 SER 41 35 35 SER SER B . n B 1 42 SER 42 36 36 SER SER B . n B 1 43 ASN 43 37 37 ASN ASN B . n B 1 44 VAL 44 38 38 VAL VAL B . n B 1 45 TRP 45 39 39 TRP TRP B . n B 1 46 VAL 46 40 40 VAL VAL B . n B 1 47 PRO 47 41 41 PRO PRO B . n B 1 48 SER 48 42 42 SER SER B . n B 1 49 SER 49 43 43 SER SER B . n B 1 50 LYS 50 44 44 LYS LYS B . n B 1 51 CYS 51 45 45 CYS CYS B . n B 1 52 SER 52 46 46 SER SER B . n B 1 53 ARG 53 47 47 ARG ARG B . n B 1 54 LEU 54 47 47 LEU LEU B A n B 1 55 TYR 55 47 47 TYR TYR B B n B 1 56 THR 56 48 48 THR THR B . n B 1 57 ALA 57 49 49 ALA ALA B . n B 1 58 CYS 58 50 50 CYS CYS B . n B 1 59 VAL 59 51 51 VAL VAL B . n B 1 60 TYR 60 52 52 TYR TYR B . n B 1 61 HIS 61 53 53 HIS HIS B . n B 1 62 LYS 62 54 54 LYS LYS B . n B 1 63 LEU 63 55 55 LEU LEU B . n B 1 64 PHE 64 56 56 PHE PHE B . n B 1 65 ASP 65 57 57 ASP ASP B . n B 1 66 ALA 66 58 58 ALA ALA B . n B 1 67 SER 67 59 59 SER SER B . n B 1 68 ASP 68 60 60 ASP ASP B . n B 1 69 SER 69 61 61 SER SER B . n B 1 70 SER 70 62 62 SER SER B . n B 1 71 SER 71 63 63 SER SER B . n B 1 72 TYR 72 64 64 TYR TYR B . n B 1 73 LYS 73 65 65 LYS LYS B . n B 1 74 HIS 74 66 66 HIS HIS B . n B 1 75 ASN 75 67 67 ASN ASN B . n B 1 76 GLY 76 68 68 GLY GLY B . n B 1 77 THR 77 69 69 THR THR B . n B 1 78 GLU 78 70 70 GLU GLU B . n B 1 79 LEU 79 71 71 LEU LEU B . n B 1 80 THR 80 72 72 THR THR B . n B 1 81 LEU 81 73 73 LEU LEU B . n B 1 82 ARG 82 74 74 ARG ARG B . n B 1 83 TYR 83 75 75 TYR TYR B . n B 1 84 SER 84 76 76 SER SER B . n B 1 85 THR 85 77 77 THR THR B . n B 1 86 GLY 86 78 78 GLY GLY B . n B 1 87 THR 87 79 79 THR THR B . n B 1 88 VAL 88 80 80 VAL VAL B . n B 1 89 SER 89 81 81 SER SER B . n B 1 90 GLY 90 82 82 GLY GLY B . n B 1 91 PHE 91 83 83 PHE PHE B . n B 1 92 LEU 92 84 84 LEU LEU B . n B 1 93 SER 93 85 85 SER SER B . n B 1 94 GLN 94 86 86 GLN GLN B . n B 1 95 ASP 95 87 87 ASP ASP B . n B 1 96 ILE 96 88 88 ILE ILE B . n B 1 97 ILE 97 89 89 ILE ILE B . n B 1 98 THR 98 90 90 THR THR B . n B 1 99 VAL 99 91 91 VAL VAL B . n B 1 100 GLY 100 92 92 GLY GLY B . n B 1 101 GLY 101 93 93 GLY GLY B . n B 1 102 ILE 102 94 94 ILE ILE B . n B 1 103 THR 103 95 95 THR THR B . n B 1 104 VAL 104 96 96 VAL VAL B . n B 1 105 THR 105 97 97 THR THR B . n B 1 106 GLN 106 99 99 GLN GLN B . n B 1 107 MET 107 100 100 MET MET B . n B 1 108 PHE 108 101 101 PHE PHE B . n B 1 109 GLY 109 102 102 GLY GLY B . n B 1 110 GLU 110 103 103 GLU GLU B . n B 1 111 VAL 111 104 104 VAL VAL B . n B 1 112 THR 112 105 105 THR THR B . n B 1 113 GLU 113 106 106 GLU GLU B . n B 1 114 MET 114 107 107 MET MET B . n B 1 115 PRO 115 108 108 PRO PRO B . n B 1 116 ALA 116 109 109 ALA ALA B . n B 1 117 LEU 117 110 110 LEU LEU B . n B 1 118 PRO 118 111 111 PRO PRO B . n B 1 119 PHE 119 112 112 PHE PHE B . n B 1 120 MET 120 113 113 MET MET B . n B 1 121 LEU 121 114 114 LEU LEU B . n B 1 122 ALA 122 115 115 ALA ALA B . n B 1 123 GLU 123 116 116 GLU GLU B . n B 1 124 PHE 124 117 117 PHE PHE B . n B 1 125 ASP 125 118 118 ASP ASP B . n B 1 126 GLY 126 119 119 GLY GLY B . n B 1 127 VAL 127 120 120 VAL VAL B . n B 1 128 VAL 128 121 121 VAL VAL B . n B 1 129 GLY 129 122 122 GLY GLY B . n B 1 130 MET 130 123 123 MET MET B . n B 1 131 GLY 131 124 124 GLY GLY B . n B 1 132 PHE 132 125 125 PHE PHE B . n B 1 133 ILE 133 126 126 ILE ILE B . n B 1 134 GLU 134 127 127 GLU GLU B . n B 1 135 GLN 135 128 128 GLN GLN B . n B 1 136 ALA 136 129 129 ALA ALA B . n B 1 137 ILE 137 130 130 ILE ILE B . n B 1 138 GLY 138 131 131 GLY GLY B . n B 1 139 ARG 139 132 132 ARG ARG B . n B 1 140 VAL 140 133 133 VAL VAL B . n B 1 141 THR 141 134 134 THR THR B . n B 1 142 PRO 142 135 135 PRO PRO B . n B 1 143 ILE 143 136 136 ILE ILE B . n B 1 144 PHE 144 137 137 PHE PHE B . n B 1 145 ASP 145 138 138 ASP ASP B . n B 1 146 ASN 146 139 139 ASN ASN B . n B 1 147 ILE 147 140 140 ILE ILE B . n B 1 148 ILE 148 141 141 ILE ILE B . n B 1 149 SER 149 142 142 SER SER B . n B 1 150 GLN 150 143 143 GLN GLN B . n B 1 151 GLY 151 144 144 GLY GLY B . n B 1 152 VAL 152 145 145 VAL VAL B . n B 1 153 LEU 153 146 146 LEU LEU B . n B 1 154 LYS 154 147 147 LYS LYS B . n B 1 155 GLU 155 148 148 GLU GLU B . n B 1 156 ASP 156 149 149 ASP ASP B . n B 1 157 VAL 157 150 150 VAL VAL B . n B 1 158 PHE 158 151 151 PHE PHE B . n B 1 159 SER 159 152 152 SER SER B . n B 1 160 PHE 160 153 153 PHE PHE B . n B 1 161 TYR 161 154 154 TYR TYR B . n B 1 162 TYR 162 155 155 TYR TYR B . n B 1 163 ASN 163 156 156 ASN ASN B . n B 1 164 ARG 164 157 157 ARG ARG B . n B 1 165 ASP 165 158 158 ASP ASP B . n B 1 166 SER 166 159 159 SER SER B . n B 1 167 GLU 167 159 ? ? ? B A n B 1 168 ASN 168 159 ? ? ? B B n B 1 169 SER 169 159 ? ? ? B C n B 1 170 GLN 170 160 160 GLN GLN B C n B 1 171 SER 171 160 160 SER SER B D n B 1 172 LEU 172 161 161 LEU LEU B . n B 1 173 GLY 173 162 162 GLY GLY B . n B 1 174 GLY 174 163 163 GLY GLY B . n B 1 175 GLN 175 164 164 GLN GLN B . n B 1 176 ILE 176 165 165 ILE ILE B . n B 1 177 VAL 177 166 166 VAL VAL B . n B 1 178 LEU 178 167 167 LEU LEU B . n B 1 179 GLY 179 168 168 GLY GLY B . n B 1 180 GLY 180 169 169 GLY GLY B . n B 1 181 SER 181 170 170 SER SER B . n B 1 182 ASP 182 171 171 ASP ASP B . n B 1 183 PRO 183 172 172 PRO PRO B . n B 1 184 GLN 184 173 173 GLN GLN B . n B 1 185 HIS 185 174 174 HIS HIS B . n B 1 186 TYR 186 175 175 TYR TYR B . n B 1 187 GLU 187 176 176 GLU GLU B . n B 1 188 GLY 188 177 177 GLY GLY B . n B 1 189 ASN 189 178 178 ASN ASN B . n B 1 190 PHE 190 179 179 PHE PHE B . n B 1 191 HIS 191 180 180 HIS HIS B . n B 1 192 TYR 192 181 181 TYR TYR B . n B 1 193 ILE 193 182 182 ILE ILE B . n B 1 194 ASN 194 183 183 ASN ASN B . n B 1 195 LEU 195 184 184 LEU LEU B . n B 1 196 ILE 196 185 185 ILE ILE B . n B 1 197 LYS 197 186 186 LYS LYS B . n B 1 198 THR 198 187 187 THR THR B . n B 1 199 GLY 199 188 188 GLY GLY B . n B 1 200 VAL 200 189 189 VAL VAL B . n B 1 201 TRP 201 190 190 TRP TRP B . n B 1 202 GLN 202 191 191 GLN GLN B . n B 1 203 ILE 203 192 192 ILE ILE B . n B 1 204 GLN 204 193 193 GLN GLN B . n B 1 205 MET 205 194 194 MET MET B . n B 1 206 LYS 206 195 195 LYS LYS B . n B 1 207 GLY 207 196 196 GLY GLY B . n B 1 208 VAL 208 197 197 VAL VAL B . n B 1 209 SER 209 198 198 SER SER B . n B 1 210 VAL 210 199 199 VAL VAL B . n B 1 211 GLY 211 200 200 GLY GLY B . n B 1 212 SER 212 201 201 SER SER B . n B 1 213 SER 213 202 202 SER SER B . n B 1 214 THR 214 203 203 THR THR B . n B 1 215 LEU 215 204 204 LEU LEU B . n B 1 216 LEU 216 205 205 LEU LEU B . n B 1 217 CYS 217 206 206 CYS CYS B . n B 1 218 GLU 218 207 207 GLU GLU B . n B 1 219 ASP 219 208 208 ASP ASP B . n B 1 220 GLY 220 209 209 GLY GLY B . n B 1 221 CYS 221 210 210 CYS CYS B . n B 1 222 LEU 222 211 211 LEU LEU B . n B 1 223 ALA 223 212 212 ALA ALA B . n B 1 224 LEU 224 213 213 LEU LEU B . n B 1 225 VAL 225 214 214 VAL VAL B . n B 1 226 ASP 226 215 215 ASP ASP B . n B 1 227 THR 227 216 216 THR THR B . n B 1 228 GLY 228 217 217 GLY GLY B . n B 1 229 ALA 229 218 218 ALA ALA B . n B 1 230 SER 230 219 219 SER SER B . n B 1 231 TYR 231 220 220 TYR TYR B . n B 1 232 ILE 232 221 221 ILE ILE B . n B 1 233 SER 233 222 222 SER SER B . n B 1 234 GLY 234 223 223 GLY GLY B . n B 1 235 SER 235 224 224 SER SER B . n B 1 236 THR 236 225 225 THR THR B . n B 1 237 SER 237 226 226 SER SER B . n B 1 238 SER 238 227 227 SER SER B . n B 1 239 ILE 239 228 228 ILE ILE B . n B 1 240 GLU 240 229 229 GLU GLU B . n B 1 241 LYS 241 230 230 LYS LYS B . n B 1 242 LEU 242 231 231 LEU LEU B . n B 1 243 MET 243 232 232 MET MET B . n B 1 244 GLU 244 233 233 GLU GLU B . n B 1 245 ALA 245 234 234 ALA ALA B . n B 1 246 LEU 246 235 235 LEU LEU B . n B 1 247 GLY 247 236 236 GLY GLY B . n B 1 248 ALA 248 237 237 ALA ALA B . n B 1 249 LYS 249 238 238 LYS LYS B . n B 1 250 LYS 250 239 239 LYS LYS B . n B 1 251 ARG 251 240 240 ARG ARG B . n B 1 252 LEU 252 241 241 LEU LEU B . n B 1 253 PHE 253 242 242 PHE PHE B . n B 1 254 ASP 254 244 244 ASP ASP B . n B 1 255 TYR 255 245 245 TYR TYR B . n B 1 256 VAL 256 246 246 VAL VAL B . n B 1 257 VAL 257 247 247 VAL VAL B . n B 1 258 LYS 258 248 248 LYS LYS B . n B 1 259 CYS 259 249 249 CYS CYS B . n B 1 260 ASN 260 250 250 ASN ASN B . n B 1 261 GLU 261 251 251 GLU GLU B . n B 1 262 GLY 262 252 252 GLY GLY B . n B 1 263 PRO 263 253 253 PRO PRO B . n B 1 264 THR 264 254 254 THR THR B . n B 1 265 LEU 265 255 255 LEU LEU B . n B 1 266 PRO 266 256 256 PRO PRO B . n B 1 267 ASP 267 257 257 ASP ASP B . n B 1 268 ILE 268 258 258 ILE ILE B . n B 1 269 SER 269 259 259 SER SER B . n B 1 270 PHE 270 260 260 PHE PHE B . n B 1 271 HIS 271 261 261 HIS HIS B . n B 1 272 LEU 272 262 262 LEU LEU B . n B 1 273 GLY 273 263 263 GLY GLY B . n B 1 274 GLY 274 264 264 GLY GLY B . n B 1 275 LYS 275 265 265 LYS LYS B . n B 1 276 GLU 276 266 266 GLU GLU B . n B 1 277 TYR 277 267 267 TYR TYR B . n B 1 278 THR 278 268 268 THR THR B . n B 1 279 LEU 279 269 269 LEU LEU B . n B 1 280 THR 280 270 270 THR THR B . n B 1 281 SER 281 271 271 SER SER B . n B 1 282 ALA 282 272 272 ALA ALA B . n B 1 283 ASP 283 273 273 ASP ASP B . n B 1 284 TYR 284 274 274 TYR TYR B . n B 1 285 VAL 285 275 275 VAL VAL B . n B 1 286 PHE 286 276 276 PHE PHE B . n B 1 287 GLN 287 277 277 GLN GLN B . n B 1 288 GLU 288 278 278 GLU GLU B . n B 1 289 SER 289 279 279 SER SER B . n B 1 290 TYR 290 280 280 TYR TYR B . n B 1 291 SER 291 281 281 SER SER B . n B 1 292 SER 292 281 281 SER SER B A n B 1 293 LYS 293 281 281 LYS LYS B B n B 1 294 LYS 294 281 281 LYS LYS B C n B 1 295 LEU 295 281 281 LEU LEU B D n B 1 296 CYS 296 282 282 CYS CYS B . n B 1 297 THR 297 283 283 THR THR B . n B 1 298 LEU 298 284 284 LEU LEU B . n B 1 299 ALA 299 285 285 ALA ALA B . n B 1 300 ILE 300 286 286 ILE ILE B . n B 1 301 HIS 301 287 287 HIS HIS B . n B 1 302 ALA 302 288 288 ALA ALA B . n B 1 303 MET 303 289 289 MET MET B . n B 1 304 ASP 304 290 290 ASP ASP B . n B 1 305 ILE 305 291 291 ILE ILE B . n B 1 306 PRO 306 292 292 PRO PRO B . n B 1 307 PRO 307 293 293 PRO PRO B . n B 1 308 PRO 308 294 294 PRO PRO B . n B 1 309 THR 309 295 295 THR THR B . n B 1 310 GLY 310 296 296 GLY GLY B . n B 1 311 PRO 311 297 297 PRO PRO B . n B 1 312 THR 312 298 298 THR THR B . n B 1 313 TRP 313 299 299 TRP TRP B . n B 1 314 ALA 314 300 300 ALA ALA B . n B 1 315 LEU 315 301 301 LEU LEU B . n B 1 316 GLY 316 302 302 GLY GLY B . n B 1 317 ALA 317 303 303 ALA ALA B . n B 1 318 THR 318 304 304 THR THR B . n B 1 319 PHE 319 305 305 PHE PHE B . n B 1 320 ILE 320 306 306 ILE ILE B . n B 1 321 ARG 321 307 307 ARG ARG B . n B 1 322 LYS 322 308 308 LYS LYS B . n B 1 323 PHE 323 309 309 PHE PHE B . n B 1 324 TYR 324 310 310 TYR TYR B . n B 1 325 THR 325 311 311 THR THR B . n B 1 326 GLU 326 312 312 GLU GLU B . n B 1 327 PHE 327 313 313 PHE PHE B . n B 1 328 ASP 328 314 314 ASP ASP B . n B 1 329 ARG 329 315 315 ARG ARG B . n B 1 330 ARG 330 316 316 ARG ARG B . n B 1 331 ASN 331 317 317 ASN ASN B . n B 1 332 ASN 332 318 318 ASN ASN B . n B 1 333 ARG 333 319 319 ARG ARG B . n B 1 334 ILE 334 320 320 ILE ILE B . n B 1 335 GLY 335 321 321 GLY GLY B . n B 1 336 PHE 336 322 322 PHE PHE B . n B 1 337 ALA 337 323 323 ALA ALA B . n B 1 338 LEU 338 324 324 LEU LEU B . n B 1 339 ALA 339 325 325 ALA ALA B . n B 1 340 ARG 340 326 326 ARG ARG B . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code C 2 NAG 1 1000 1000 NAG NAG A . D 3 3ZJ 1 1001 1001 3ZJ LI1 A . E 4 SO4 1 1002 1002 SO4 SO4 A . F 2 NAG 1 1000 1000 NAG NAG B . G 3 3ZJ 1 1001 1001 3ZJ LI1 B . H 5 DMS 1 1002 1002 DMS DMS B . I 5 DMS 1 1003 1003 DMS DMS B . J 6 HOH 1 1101 2 HOH HOH A . J 6 HOH 2 1102 4 HOH HOH A . J 6 HOH 3 1103 6 HOH HOH A . J 6 HOH 4 1104 8 HOH HOH A . J 6 HOH 5 1105 10 HOH HOH A . J 6 HOH 6 1106 11 HOH HOH A . J 6 HOH 7 1107 12 HOH HOH A . J 6 HOH 8 1108 19 HOH HOH A . J 6 HOH 9 1109 21 HOH HOH A . J 6 HOH 10 1110 22 HOH HOH A . J 6 HOH 11 1111 25 HOH HOH A . J 6 HOH 12 1112 26 HOH HOH A . J 6 HOH 13 1113 28 HOH HOH A . J 6 HOH 14 1114 29 HOH HOH A . J 6 HOH 15 1115 30 HOH HOH A . J 6 HOH 16 1116 32 HOH HOH A . J 6 HOH 17 1117 34 HOH HOH A . J 6 HOH 18 1118 35 HOH HOH A . J 6 HOH 19 1119 36 HOH HOH A . J 6 HOH 20 1120 37 HOH HOH A . J 6 HOH 21 1121 38 HOH HOH A . J 6 HOH 22 1122 40 HOH HOH A . J 6 HOH 23 1123 42 HOH HOH A . J 6 HOH 24 1124 43 HOH HOH A . J 6 HOH 25 1125 46 HOH HOH A . J 6 HOH 26 1126 48 HOH HOH A . J 6 HOH 27 1127 49 HOH HOH A . J 6 HOH 28 1128 51 HOH HOH A . J 6 HOH 29 1129 54 HOH HOH A . J 6 HOH 30 1130 55 HOH HOH A . J 6 HOH 31 1131 57 HOH HOH A . J 6 HOH 32 1132 58 HOH HOH A . J 6 HOH 33 1133 60 HOH HOH A . J 6 HOH 34 1134 62 HOH HOH A . J 6 HOH 35 1135 66 HOH HOH A . J 6 HOH 36 1136 69 HOH HOH A . J 6 HOH 37 1137 70 HOH HOH A . J 6 HOH 38 1138 71 HOH HOH A . J 6 HOH 39 1139 72 HOH HOH A . J 6 HOH 40 1140 77 HOH HOH A . J 6 HOH 41 1141 78 HOH HOH A . J 6 HOH 42 1142 81 HOH HOH A . J 6 HOH 43 1143 82 HOH HOH A . J 6 HOH 44 1144 83 HOH HOH A . J 6 HOH 45 1145 85 HOH HOH A . J 6 HOH 46 1146 86 HOH HOH A . J 6 HOH 47 1147 87 HOH HOH A . J 6 HOH 48 1148 88 HOH HOH A . J 6 HOH 49 1149 89 HOH HOH A . J 6 HOH 50 1150 90 HOH HOH A . J 6 HOH 51 1151 91 HOH HOH A . J 6 HOH 52 1152 98 HOH HOH A . J 6 HOH 53 1153 99 HOH HOH A . J 6 HOH 54 1154 101 HOH HOH A . J 6 HOH 55 1155 102 HOH HOH A . J 6 HOH 56 1156 104 HOH HOH A . J 6 HOH 57 1157 106 HOH HOH A . J 6 HOH 58 1158 111 HOH HOH A . J 6 HOH 59 1159 112 HOH HOH A . J 6 HOH 60 1160 113 HOH HOH A . J 6 HOH 61 1161 114 HOH HOH A . J 6 HOH 62 1162 117 HOH HOH A . J 6 HOH 63 1163 118 HOH HOH A . J 6 HOH 64 1164 119 HOH HOH A . J 6 HOH 65 1165 120 HOH HOH A . J 6 HOH 66 1166 122 HOH HOH A . J 6 HOH 67 1167 125 HOH HOH A . J 6 HOH 68 1168 130 HOH HOH A . J 6 HOH 69 1169 135 HOH HOH A . J 6 HOH 70 1170 137 HOH HOH A . J 6 HOH 71 1171 138 HOH HOH A . J 6 HOH 72 1172 139 HOH HOH A . J 6 HOH 73 1173 141 HOH HOH A . J 6 HOH 74 1174 146 HOH HOH A . J 6 HOH 75 1175 147 HOH HOH A . K 6 HOH 1 1101 1 HOH HOH B . K 6 HOH 2 1102 3 HOH HOH B . K 6 HOH 3 1103 5 HOH HOH B . K 6 HOH 4 1104 7 HOH HOH B . K 6 HOH 5 1105 9 HOH HOH B . K 6 HOH 6 1106 13 HOH HOH B . K 6 HOH 7 1107 14 HOH HOH B . K 6 HOH 8 1108 15 HOH HOH B . K 6 HOH 9 1109 16 HOH HOH B . K 6 HOH 10 1110 17 HOH HOH B . K 6 HOH 11 1111 18 HOH HOH B . K 6 HOH 12 1112 20 HOH HOH B . K 6 HOH 13 1113 23 HOH HOH B . K 6 HOH 14 1114 24 HOH HOH B . K 6 HOH 15 1115 27 HOH HOH B . K 6 HOH 16 1116 31 HOH HOH B . K 6 HOH 17 1117 33 HOH HOH B . K 6 HOH 18 1118 39 HOH HOH B . K 6 HOH 19 1119 41 HOH HOH B . K 6 HOH 20 1120 44 HOH HOH B . K 6 HOH 21 1121 45 HOH HOH B . K 6 HOH 22 1122 47 HOH HOH B . K 6 HOH 23 1123 50 HOH HOH B . K 6 HOH 24 1124 52 HOH HOH B . K 6 HOH 25 1125 53 HOH HOH B . K 6 HOH 26 1126 56 HOH HOH B . K 6 HOH 27 1127 59 HOH HOH B . K 6 HOH 28 1128 61 HOH HOH B . K 6 HOH 29 1129 63 HOH HOH B . K 6 HOH 30 1130 64 HOH HOH B . K 6 HOH 31 1131 65 HOH HOH B . K 6 HOH 32 1132 67 HOH HOH B . K 6 HOH 33 1133 68 HOH HOH B . K 6 HOH 34 1134 73 HOH HOH B . K 6 HOH 35 1135 74 HOH HOH B . K 6 HOH 36 1136 75 HOH HOH B . K 6 HOH 37 1137 76 HOH HOH B . K 6 HOH 38 1138 79 HOH HOH B . K 6 HOH 39 1139 80 HOH HOH B . K 6 HOH 40 1140 84 HOH HOH B . K 6 HOH 41 1141 92 HOH HOH B . K 6 HOH 42 1142 93 HOH HOH B . K 6 HOH 43 1143 94 HOH HOH B . K 6 HOH 44 1144 95 HOH HOH B . K 6 HOH 45 1145 96 HOH HOH B . K 6 HOH 46 1146 97 HOH HOH B . K 6 HOH 47 1147 100 HOH HOH B . K 6 HOH 48 1148 103 HOH HOH B . K 6 HOH 49 1149 105 HOH HOH B . K 6 HOH 50 1150 107 HOH HOH B . K 6 HOH 51 1151 108 HOH HOH B . K 6 HOH 52 1152 109 HOH HOH B . K 6 HOH 53 1153 110 HOH HOH B . K 6 HOH 54 1154 115 HOH HOH B . K 6 HOH 55 1155 116 HOH HOH B . K 6 HOH 56 1156 121 HOH HOH B . K 6 HOH 57 1157 123 HOH HOH B . K 6 HOH 58 1158 124 HOH HOH B . K 6 HOH 59 1159 126 HOH HOH B . K 6 HOH 60 1160 127 HOH HOH B . K 6 HOH 61 1161 128 HOH HOH B . K 6 HOH 62 1162 129 HOH HOH B . K 6 HOH 63 1163 131 HOH HOH B . K 6 HOH 64 1164 132 HOH HOH B . K 6 HOH 65 1165 133 HOH HOH B . K 6 HOH 66 1166 134 HOH HOH B . K 6 HOH 67 1167 136 HOH HOH B . K 6 HOH 68 1168 140 HOH HOH B . K 6 HOH 69 1169 142 HOH HOH B . K 6 HOH 70 1170 143 HOH HOH B . K 6 HOH 71 1171 144 HOH HOH B . K 6 HOH 72 1172 145 HOH HOH B . K 6 HOH 73 1173 148 HOH HOH B . K 6 HOH 74 1174 149 HOH HOH B . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 B ASN 75 B ASN 67 ? ASN 'GLYCOSYLATION SITE' 2 A ASN 75 A ASN 67 ? ASN 'GLYCOSYLATION SITE' # loop_ _pdbx_struct_assembly.id _pdbx_struct_assembly.details _pdbx_struct_assembly.method_details _pdbx_struct_assembly.oligomeric_details _pdbx_struct_assembly.oligomeric_count 1 author_defined_assembly ? monomeric 1 2 author_defined_assembly ? monomeric 1 3 software_defined_assembly PISA hexameric 6 # loop_ _pdbx_struct_assembly_gen.assembly_id _pdbx_struct_assembly_gen.oper_expression _pdbx_struct_assembly_gen.asym_id_list 1 1 A,C,D,E,J 2 1 B,F,G,H,I,K 3 1,2,3 A,B,C,D,E,F,G,H,I,J,K # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 3 'ABSA (A^2)' 16900 ? 3 MORE -79 ? 3 'SSA (A^2)' 73020 ? # loop_ _pdbx_struct_oper_list.id _pdbx_struct_oper_list.type _pdbx_struct_oper_list.name _pdbx_struct_oper_list.symmetry_operation _pdbx_struct_oper_list.matrix[1][1] _pdbx_struct_oper_list.matrix[1][2] _pdbx_struct_oper_list.matrix[1][3] _pdbx_struct_oper_list.vector[1] _pdbx_struct_oper_list.matrix[2][1] _pdbx_struct_oper_list.matrix[2][2] _pdbx_struct_oper_list.matrix[2][3] _pdbx_struct_oper_list.vector[2] _pdbx_struct_oper_list.matrix[3][1] _pdbx_struct_oper_list.matrix[3][2] _pdbx_struct_oper_list.matrix[3][3] _pdbx_struct_oper_list.vector[3] 1 'identity operation' 1_555 x,y,z 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 2 'crystal symmetry operation' 7_564 -z+1/2,-x+1,y-1/2 0.0000000000 0.0000000000 -1.0000000000 70.8370000000 -1.0000000000 0.0000000000 0.0000000000 141.6740000000 0.0000000000 1.0000000000 0.0000000000 -70.8370000000 3 'crystal symmetry operation' 10_655 -y+1,z+1/2,-x+1/2 0.0000000000 -1.0000000000 0.0000000000 141.6740000000 0.0000000000 0.0000000000 1.0000000000 70.8370000000 -1.0000000000 0.0000000000 0.0000000000 70.8370000000 # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2015-03-25 2 'Structure model' 1 1 2015-04-08 3 'Structure model' 1 2 2015-04-22 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Database references' 2 3 'Structure model' 'Database references' # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal BUSTER refinement 2.11.4 ? 1 DENZO 'data reduction' . ? 2 SCALEPACK 'data scaling' . ? 3 # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 ARG A 47 ? ? -65.58 2.65 2 1 ASN A 67 ? ? -142.33 -69.41 3 1 TRP A 190 ? ? -96.58 56.64 4 1 THR A 203 ? ? -68.98 70.87 5 1 GLN A 277 ? ? -69.79 72.44 6 1 ALA A 285 ? ? -90.76 35.68 7 1 ARG B 47 ? ? -65.55 2.63 8 1 ASN B 67 ? ? -139.13 -64.93 9 1 THR B 203 ? ? -68.26 88.57 10 1 ARG B 240 ? ? -74.51 -79.98 11 1 LEU B 241 ? ? -130.13 -35.81 12 1 ALA B 285 ? ? -87.97 32.38 # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 Y 1 A SER 159 ? OG ? A SER 166 OG 2 1 Y 1 A GLN 160 C CG ? A GLN 170 CG 3 1 Y 1 A GLN 160 C CD ? A GLN 170 CD 4 1 Y 1 A GLN 160 C OE1 ? A GLN 170 OE1 5 1 Y 1 A GLN 160 C NE2 ? A GLN 170 NE2 6 1 Y 1 B SER 159 ? OG ? B SER 166 OG 7 1 Y 1 B GLN 160 C CG ? B GLN 170 CG 8 1 Y 1 B GLN 160 C CD ? B GLN 170 CD 9 1 Y 1 B GLN 160 C OE1 ? B GLN 170 OE1 10 1 Y 1 B GLN 160 C NE2 ? B GLN 170 NE2 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A LEU -5 ? A LEU 1 2 1 Y 1 A GLU 159 A A GLU 167 3 1 Y 1 A ASN 159 B A ASN 168 4 1 Y 1 A SER 159 C A SER 169 5 1 Y 1 B GLU 159 A B GLU 167 6 1 Y 1 B ASN 159 B B ASN 168 7 1 Y 1 B SER 159 C B SER 169 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 'N-({(3S,4S)-4-[(benzylsulfonyl)amino]pyrrolidin-3-yl}methyl)-4-methoxy-3-(3-methoxypropoxy)-N-(propan-2-yl)benzamide' 3ZJ 4 'SULFATE ION' SO4 5 'DIMETHYL SULFOXIDE' DMS 6 water HOH #