data_4OBS # _entry.id 4OBS # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.281 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 4OBS RCSB RCSB084293 WWPDB D_1000084293 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.details _pdbx_database_related.content_type PDB 4MJ2 'R3 apo-IDUA structure' unspecified PDB 4MJ4 'P21 apo-iduronidase structure' unspecified PDB 4KGJ 'iduronidase complex with 5-fluoro-alpha-L-idopyranosyluronic acid fluoride' unspecified PDB 4KH2 'iduronidase complex with 2-deoxy-2-fluoro-alpha-L-idopyranosyluronic acid fluoride' unspecified PDB 4KGL 'iduronidase complex with [2R,3R,4R,5S]-2-carboxy-3,4,5-trihydroxy-piperidine' unspecified PDB 4OBR . unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 4OBS _pdbx_database_status.recvd_initial_deposition_date 2014-01-07 _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry ? _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? _pdbx_database_status.pdb_format_compatible Y # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Bie, H.' 1 'Yin, J.' 2 'He, X.' 3 'Kermode, A.R.' 4 'James, M.N.G.' 5 # _citation.id primary _citation.title 'Crystal structure of human alpha-L-iduronidase in the P212121 form' _citation.journal_abbrev 'To be Published' _citation.journal_volume ? _citation.page_first ? _citation.page_last ? _citation.year ? _citation.journal_id_ASTM ? _citation.country ? _citation.journal_id_ISSN ? _citation.journal_id_CSD 0353 _citation.book_publisher ? _citation.pdbx_database_id_PubMed ? _citation.pdbx_database_id_DOI ? # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Bie, H.' 1 primary 'Yin, J.' 2 primary 'He, X.' 3 primary 'Kermode, A.R.' 4 primary 'James, M.N.G.' 5 # _cell.entry_id 4OBS _cell.length_a 72.640 _cell.length_b 78.030 _cell.length_c 112.460 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 90.00 _cell.Z_PDB 4 _cell.pdbx_unique_axis ? _cell.length_a_esd ? _cell.length_b_esd ? _cell.length_c_esd ? _cell.angle_alpha_esd ? _cell.angle_beta_esd ? _cell.angle_gamma_esd ? # _symmetry.entry_id 4OBS _symmetry.space_group_name_H-M 'P 21 21 21' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 19 _symmetry.space_group_name_Hall ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man Alpha-L-iduronidase 70053.320 1 3.2.1.76 ? 'UNP residues 27-653' ? 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 4 ? ? ? ? 3 non-polymer man BETA-D-MANNOSE 180.156 1 ? ? ? ? 4 non-polymer man ALPHA-D-MANNOSE 180.156 3 ? ? ? ? 5 non-polymer syn GLYCEROL 92.094 6 ? ? ? ? 6 non-polymer syn 'CHLORIDE ION' 35.453 1 ? ? ? ? 7 non-polymer syn 'SULFATE ION' 96.063 1 ? ? ? ? 8 water nat water 18.015 143 ? ? ? ? # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;EAPHLVQVDAARALWPLRRFWRSTGFCPPLPHSQADPYVLSWDQQLNLAYVGAVPHRGIKQVRTHWLLELVTTRGSTGQG LSYNFTHLDGYLDLLRENQLLPGFELMGSASGHFTDFEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETWNEPDHH DFDNVSMTMQGFLNYYDACSEGLRAASPALRLGGPGDSFHTPPRSPLSWGLLRHCHDGTNFFTGEAGVRLDYISLHRKGA RSSISILEQEKVVAQQIRQLFPKFADTPIYNDEADPLVGWSLPQPWRADVTYAAMVVKVIAQHQNLLLANTTSAFPYALL SNDNAFLSYHPHPFAQRTLTARFQVNNTRPPHVQLLRKPVLTAMGLLALLDEEQLWAEVSQAGTVLDSNHTVGVLASAHR PQGPADAWRAAVLIYASDDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGLCSPDGEWRRLGRPVFPTAEQFRRMRA AEDPVAAAPRPLPAGGRLTLRPALRLPSLLLVHVCARPEKPPGQVTRLRALPLTQGQLVLVWSDEHVGSKCLWTYEIQFS QDGKAYTPVSRKPSTFNLFVFSPDTGAVSGSYRVRALDYWARPGPFSDPVPYLEVPVPRGPPSPGNP ; _entity_poly.pdbx_seq_one_letter_code_can ;EAPHLVQVDAARALWPLRRFWRSTGFCPPLPHSQADPYVLSWDQQLNLAYVGAVPHRGIKQVRTHWLLELVTTRGSTGQG LSYNFTHLDGYLDLLRENQLLPGFELMGSASGHFTDFEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETWNEPDHH DFDNVSMTMQGFLNYYDACSEGLRAASPALRLGGPGDSFHTPPRSPLSWGLLRHCHDGTNFFTGEAGVRLDYISLHRKGA RSSISILEQEKVVAQQIRQLFPKFADTPIYNDEADPLVGWSLPQPWRADVTYAAMVVKVIAQHQNLLLANTTSAFPYALL SNDNAFLSYHPHPFAQRTLTARFQVNNTRPPHVQLLRKPVLTAMGLLALLDEEQLWAEVSQAGTVLDSNHTVGVLASAHR PQGPADAWRAAVLIYASDDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGLCSPDGEWRRLGRPVFPTAEQFRRMRA AEDPVAAAPRPLPAGGRLTLRPALRLPSLLLVHVCARPEKPPGQVTRLRALPLTQGQLVLVWSDEHVGSKCLWTYEIQFS QDGKAYTPVSRKPSTFNLFVFSPDTGAVSGSYRVRALDYWARPGPFSDPVPYLEVPVPRGPPSPGNP ; _entity_poly.pdbx_strand_id A _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 GLU n 1 2 ALA n 1 3 PRO n 1 4 HIS n 1 5 LEU n 1 6 VAL n 1 7 GLN n 1 8 VAL n 1 9 ASP n 1 10 ALA n 1 11 ALA n 1 12 ARG n 1 13 ALA n 1 14 LEU n 1 15 TRP n 1 16 PRO n 1 17 LEU n 1 18 ARG n 1 19 ARG n 1 20 PHE n 1 21 TRP n 1 22 ARG n 1 23 SER n 1 24 THR n 1 25 GLY n 1 26 PHE n 1 27 CYS n 1 28 PRO n 1 29 PRO n 1 30 LEU n 1 31 PRO n 1 32 HIS n 1 33 SER n 1 34 GLN n 1 35 ALA n 1 36 ASP n 1 37 PRO n 1 38 TYR n 1 39 VAL n 1 40 LEU n 1 41 SER n 1 42 TRP n 1 43 ASP n 1 44 GLN n 1 45 GLN n 1 46 LEU n 1 47 ASN n 1 48 LEU n 1 49 ALA n 1 50 TYR n 1 51 VAL n 1 52 GLY n 1 53 ALA n 1 54 VAL n 1 55 PRO n 1 56 HIS n 1 57 ARG n 1 58 GLY n 1 59 ILE n 1 60 LYS n 1 61 GLN n 1 62 VAL n 1 63 ARG n 1 64 THR n 1 65 HIS n 1 66 TRP n 1 67 LEU n 1 68 LEU n 1 69 GLU n 1 70 LEU n 1 71 VAL n 1 72 THR n 1 73 THR n 1 74 ARG n 1 75 GLY n 1 76 SER n 1 77 THR n 1 78 GLY n 1 79 GLN n 1 80 GLY n 1 81 LEU n 1 82 SER n 1 83 TYR n 1 84 ASN n 1 85 PHE n 1 86 THR n 1 87 HIS n 1 88 LEU n 1 89 ASP n 1 90 GLY n 1 91 TYR n 1 92 LEU n 1 93 ASP n 1 94 LEU n 1 95 LEU n 1 96 ARG n 1 97 GLU n 1 98 ASN n 1 99 GLN n 1 100 LEU n 1 101 LEU n 1 102 PRO n 1 103 GLY n 1 104 PHE n 1 105 GLU n 1 106 LEU n 1 107 MET n 1 108 GLY n 1 109 SER n 1 110 ALA n 1 111 SER n 1 112 GLY n 1 113 HIS n 1 114 PHE n 1 115 THR n 1 116 ASP n 1 117 PHE n 1 118 GLU n 1 119 ASP n 1 120 LYS n 1 121 GLN n 1 122 GLN n 1 123 VAL n 1 124 PHE n 1 125 GLU n 1 126 TRP n 1 127 LYS n 1 128 ASP n 1 129 LEU n 1 130 VAL n 1 131 SER n 1 132 SER n 1 133 LEU n 1 134 ALA n 1 135 ARG n 1 136 ARG n 1 137 TYR n 1 138 ILE n 1 139 GLY n 1 140 ARG n 1 141 TYR n 1 142 GLY n 1 143 LEU n 1 144 ALA n 1 145 HIS n 1 146 VAL n 1 147 SER n 1 148 LYS n 1 149 TRP n 1 150 ASN n 1 151 PHE n 1 152 GLU n 1 153 THR n 1 154 TRP n 1 155 ASN n 1 156 GLU n 1 157 PRO n 1 158 ASP n 1 159 HIS n 1 160 HIS n 1 161 ASP n 1 162 PHE n 1 163 ASP n 1 164 ASN n 1 165 VAL n 1 166 SER n 1 167 MET n 1 168 THR n 1 169 MET n 1 170 GLN n 1 171 GLY n 1 172 PHE n 1 173 LEU n 1 174 ASN n 1 175 TYR n 1 176 TYR n 1 177 ASP n 1 178 ALA n 1 179 CYS n 1 180 SER n 1 181 GLU n 1 182 GLY n 1 183 LEU n 1 184 ARG n 1 185 ALA n 1 186 ALA n 1 187 SER n 1 188 PRO n 1 189 ALA n 1 190 LEU n 1 191 ARG n 1 192 LEU n 1 193 GLY n 1 194 GLY n 1 195 PRO n 1 196 GLY n 1 197 ASP n 1 198 SER n 1 199 PHE n 1 200 HIS n 1 201 THR n 1 202 PRO n 1 203 PRO n 1 204 ARG n 1 205 SER n 1 206 PRO n 1 207 LEU n 1 208 SER n 1 209 TRP n 1 210 GLY n 1 211 LEU n 1 212 LEU n 1 213 ARG n 1 214 HIS n 1 215 CYS n 1 216 HIS n 1 217 ASP n 1 218 GLY n 1 219 THR n 1 220 ASN n 1 221 PHE n 1 222 PHE n 1 223 THR n 1 224 GLY n 1 225 GLU n 1 226 ALA n 1 227 GLY n 1 228 VAL n 1 229 ARG n 1 230 LEU n 1 231 ASP n 1 232 TYR n 1 233 ILE n 1 234 SER n 1 235 LEU n 1 236 HIS n 1 237 ARG n 1 238 LYS n 1 239 GLY n 1 240 ALA n 1 241 ARG n 1 242 SER n 1 243 SER n 1 244 ILE n 1 245 SER n 1 246 ILE n 1 247 LEU n 1 248 GLU n 1 249 GLN n 1 250 GLU n 1 251 LYS n 1 252 VAL n 1 253 VAL n 1 254 ALA n 1 255 GLN n 1 256 GLN n 1 257 ILE n 1 258 ARG n 1 259 GLN n 1 260 LEU n 1 261 PHE n 1 262 PRO n 1 263 LYS n 1 264 PHE n 1 265 ALA n 1 266 ASP n 1 267 THR n 1 268 PRO n 1 269 ILE n 1 270 TYR n 1 271 ASN n 1 272 ASP n 1 273 GLU n 1 274 ALA n 1 275 ASP n 1 276 PRO n 1 277 LEU n 1 278 VAL n 1 279 GLY n 1 280 TRP n 1 281 SER n 1 282 LEU n 1 283 PRO n 1 284 GLN n 1 285 PRO n 1 286 TRP n 1 287 ARG n 1 288 ALA n 1 289 ASP n 1 290 VAL n 1 291 THR n 1 292 TYR n 1 293 ALA n 1 294 ALA n 1 295 MET n 1 296 VAL n 1 297 VAL n 1 298 LYS n 1 299 VAL n 1 300 ILE n 1 301 ALA n 1 302 GLN n 1 303 HIS n 1 304 GLN n 1 305 ASN n 1 306 LEU n 1 307 LEU n 1 308 LEU n 1 309 ALA n 1 310 ASN n 1 311 THR n 1 312 THR n 1 313 SER n 1 314 ALA n 1 315 PHE n 1 316 PRO n 1 317 TYR n 1 318 ALA n 1 319 LEU n 1 320 LEU n 1 321 SER n 1 322 ASN n 1 323 ASP n 1 324 ASN n 1 325 ALA n 1 326 PHE n 1 327 LEU n 1 328 SER n 1 329 TYR n 1 330 HIS n 1 331 PRO n 1 332 HIS n 1 333 PRO n 1 334 PHE n 1 335 ALA n 1 336 GLN n 1 337 ARG n 1 338 THR n 1 339 LEU n 1 340 THR n 1 341 ALA n 1 342 ARG n 1 343 PHE n 1 344 GLN n 1 345 VAL n 1 346 ASN n 1 347 ASN n 1 348 THR n 1 349 ARG n 1 350 PRO n 1 351 PRO n 1 352 HIS n 1 353 VAL n 1 354 GLN n 1 355 LEU n 1 356 LEU n 1 357 ARG n 1 358 LYS n 1 359 PRO n 1 360 VAL n 1 361 LEU n 1 362 THR n 1 363 ALA n 1 364 MET n 1 365 GLY n 1 366 LEU n 1 367 LEU n 1 368 ALA n 1 369 LEU n 1 370 LEU n 1 371 ASP n 1 372 GLU n 1 373 GLU n 1 374 GLN n 1 375 LEU n 1 376 TRP n 1 377 ALA n 1 378 GLU n 1 379 VAL n 1 380 SER n 1 381 GLN n 1 382 ALA n 1 383 GLY n 1 384 THR n 1 385 VAL n 1 386 LEU n 1 387 ASP n 1 388 SER n 1 389 ASN n 1 390 HIS n 1 391 THR n 1 392 VAL n 1 393 GLY n 1 394 VAL n 1 395 LEU n 1 396 ALA n 1 397 SER n 1 398 ALA n 1 399 HIS n 1 400 ARG n 1 401 PRO n 1 402 GLN n 1 403 GLY n 1 404 PRO n 1 405 ALA n 1 406 ASP n 1 407 ALA n 1 408 TRP n 1 409 ARG n 1 410 ALA n 1 411 ALA n 1 412 VAL n 1 413 LEU n 1 414 ILE n 1 415 TYR n 1 416 ALA n 1 417 SER n 1 418 ASP n 1 419 ASP n 1 420 THR n 1 421 ARG n 1 422 ALA n 1 423 HIS n 1 424 PRO n 1 425 ASN n 1 426 ARG n 1 427 SER n 1 428 VAL n 1 429 ALA n 1 430 VAL n 1 431 THR n 1 432 LEU n 1 433 ARG n 1 434 LEU n 1 435 ARG n 1 436 GLY n 1 437 VAL n 1 438 PRO n 1 439 PRO n 1 440 GLY n 1 441 PRO n 1 442 GLY n 1 443 LEU n 1 444 VAL n 1 445 TYR n 1 446 VAL n 1 447 THR n 1 448 ARG n 1 449 TYR n 1 450 LEU n 1 451 ASP n 1 452 ASN n 1 453 GLY n 1 454 LEU n 1 455 CYS n 1 456 SER n 1 457 PRO n 1 458 ASP n 1 459 GLY n 1 460 GLU n 1 461 TRP n 1 462 ARG n 1 463 ARG n 1 464 LEU n 1 465 GLY n 1 466 ARG n 1 467 PRO n 1 468 VAL n 1 469 PHE n 1 470 PRO n 1 471 THR n 1 472 ALA n 1 473 GLU n 1 474 GLN n 1 475 PHE n 1 476 ARG n 1 477 ARG n 1 478 MET n 1 479 ARG n 1 480 ALA n 1 481 ALA n 1 482 GLU n 1 483 ASP n 1 484 PRO n 1 485 VAL n 1 486 ALA n 1 487 ALA n 1 488 ALA n 1 489 PRO n 1 490 ARG n 1 491 PRO n 1 492 LEU n 1 493 PRO n 1 494 ALA n 1 495 GLY n 1 496 GLY n 1 497 ARG n 1 498 LEU n 1 499 THR n 1 500 LEU n 1 501 ARG n 1 502 PRO n 1 503 ALA n 1 504 LEU n 1 505 ARG n 1 506 LEU n 1 507 PRO n 1 508 SER n 1 509 LEU n 1 510 LEU n 1 511 LEU n 1 512 VAL n 1 513 HIS n 1 514 VAL n 1 515 CYS n 1 516 ALA n 1 517 ARG n 1 518 PRO n 1 519 GLU n 1 520 LYS n 1 521 PRO n 1 522 PRO n 1 523 GLY n 1 524 GLN n 1 525 VAL n 1 526 THR n 1 527 ARG n 1 528 LEU n 1 529 ARG n 1 530 ALA n 1 531 LEU n 1 532 PRO n 1 533 LEU n 1 534 THR n 1 535 GLN n 1 536 GLY n 1 537 GLN n 1 538 LEU n 1 539 VAL n 1 540 LEU n 1 541 VAL n 1 542 TRP n 1 543 SER n 1 544 ASP n 1 545 GLU n 1 546 HIS n 1 547 VAL n 1 548 GLY n 1 549 SER n 1 550 LYS n 1 551 CYS n 1 552 LEU n 1 553 TRP n 1 554 THR n 1 555 TYR n 1 556 GLU n 1 557 ILE n 1 558 GLN n 1 559 PHE n 1 560 SER n 1 561 GLN n 1 562 ASP n 1 563 GLY n 1 564 LYS n 1 565 ALA n 1 566 TYR n 1 567 THR n 1 568 PRO n 1 569 VAL n 1 570 SER n 1 571 ARG n 1 572 LYS n 1 573 PRO n 1 574 SER n 1 575 THR n 1 576 PHE n 1 577 ASN n 1 578 LEU n 1 579 PHE n 1 580 VAL n 1 581 PHE n 1 582 SER n 1 583 PRO n 1 584 ASP n 1 585 THR n 1 586 GLY n 1 587 ALA n 1 588 VAL n 1 589 SER n 1 590 GLY n 1 591 SER n 1 592 TYR n 1 593 ARG n 1 594 VAL n 1 595 ARG n 1 596 ALA n 1 597 LEU n 1 598 ASP n 1 599 TYR n 1 600 TRP n 1 601 ALA n 1 602 ARG n 1 603 PRO n 1 604 GLY n 1 605 PRO n 1 606 PHE n 1 607 SER n 1 608 ASP n 1 609 PRO n 1 610 VAL n 1 611 PRO n 1 612 TYR n 1 613 LEU n 1 614 GLU n 1 615 VAL n 1 616 PRO n 1 617 VAL n 1 618 PRO n 1 619 ARG n 1 620 GLY n 1 621 PRO n 1 622 PRO n 1 623 SER n 1 624 PRO n 1 625 GLY n 1 626 ASN n 1 627 PRO n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name human _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene IDUA _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Homo sapiens' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 9606 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name 'thale cress' _entity_src_gen.pdbx_host_org_scientific_name 'Arabidopsis thaliana' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 3702 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain 'cgl1 1' _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type plasmid _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name pARC5s3 _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code IDUA_HUMAN _struct_ref.pdbx_db_accession P35475 _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;EAPHLVHVDAARALWPLRRFWRSTGFCPPLPHSQADQYVLSWDQQLNLAYVGAVPHRGIKQVRTHWLLELVTTRGSTGRG LSYNFTHLDGYLDLLRENQLLPGFELMGSASGHFTDFEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETWNEPDHH DFDNVSMTMQGFLNYYDACSEGLRAASPALRLGGPGDSFHTPPRSPLSWGLLRHCHDGTNFFTGEAGVRLDYISLHRKGA RSSISILEQEKVVAQQIRQLFPKFADTPIYNDEADPLVGWSLPQPWRADVTYAAMVVKVIAQHQNLLLANTTSAFPYALL SNDNAFLSYHPHPFAQRTLTARFQVNNTRPPHVQLLRKPVLTAMGLLALLDEEQLWAEVSQAGTVLDSNHTVGVLASAHR PQGPADAWRAAVLIYASDDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGLCSPDGEWRRLGRPVFPTAEQFRRMRA AEDPVAAAPRPLPAGGRLTLRPALRLPSLLLVHVCARPEKPPGQVTRLRALPLTQGQLVLVWSDEHVGSKCLWTYEIQFS QDGKAYTPVSRKPSTFNLFVFSPDTGAVSGSYRVRALDYWARPGPFSDPVPYLEVPVPRGPPSPGNP ; _struct_ref.pdbx_align_begin 27 _struct_ref.pdbx_db_isoform ? # _struct_ref_seq.align_id 1 _struct_ref_seq.ref_id 1 _struct_ref_seq.pdbx_PDB_id_code 4OBS _struct_ref_seq.pdbx_strand_id A _struct_ref_seq.seq_align_beg 1 _struct_ref_seq.pdbx_seq_align_beg_ins_code ? _struct_ref_seq.seq_align_end 627 _struct_ref_seq.pdbx_seq_align_end_ins_code ? _struct_ref_seq.pdbx_db_accession P35475 _struct_ref_seq.db_align_beg 27 _struct_ref_seq.pdbx_db_align_beg_ins_code ? _struct_ref_seq.db_align_end 653 _struct_ref_seq.pdbx_db_align_end_ins_code ? _struct_ref_seq.pdbx_auth_seq_align_beg 27 _struct_ref_seq.pdbx_auth_seq_align_end 653 # loop_ _struct_ref_seq_dif.align_id _struct_ref_seq_dif.pdbx_pdb_id_code _struct_ref_seq_dif.mon_id _struct_ref_seq_dif.pdbx_pdb_strand_id _struct_ref_seq_dif.seq_num _struct_ref_seq_dif.pdbx_pdb_ins_code _struct_ref_seq_dif.pdbx_seq_db_name _struct_ref_seq_dif.pdbx_seq_db_accession_code _struct_ref_seq_dif.db_mon_id _struct_ref_seq_dif.pdbx_seq_db_seq_num _struct_ref_seq_dif.details _struct_ref_seq_dif.pdbx_auth_seq_num _struct_ref_seq_dif.pdbx_ordinal 1 4OBS GLN A 7 ? UNP P35475 HIS 33 'SEE REMARK 999' 33 1 1 4OBS PRO A 37 ? UNP P35475 GLN 63 'SEE REMARK 999' 63 2 1 4OBS GLN A 79 ? UNP P35475 ARG 105 'SEE REMARK 999' 105 3 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 BMA D-saccharide . BETA-D-MANNOSE ? 'C6 H12 O6' 180.156 CL non-polymer . 'CHLORIDE ION' ? 'Cl -1' 35.453 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 GOL non-polymer . GLYCEROL 'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3' 92.094 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MAN D-saccharide . ALPHA-D-MANNOSE ? 'C6 H12 O6' 180.156 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 SO4 non-polymer . 'SULFATE ION' ? 'O4 S -2' 96.063 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 4OBS _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 2.27 _exptl_crystal.density_percent_sol 45.93 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.temp 298 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 7.5 _exptl_crystal_grow.pdbx_details ;0.18 M sodium potassium tartrate, 18% PEG3350, 50 mM ammonium sulfate, 10 mM HEPES, pH 7.5, 3% MPD, VAPOR DIFFUSION, HANGING DROP, temperature 298K ; _exptl_crystal_grow.pdbx_pH_range ? # _diffrn.id 1 _diffrn.ambient_temp 110 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type 'RAYONIX MX300HE' _diffrn_detector.pdbx_collection_date 2013-06-04 _diffrn_detector.details 'Collimating mirror with two stripes (Si, Rh/Pt) and toroidal focusing mirror (Rh/Pt)' # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator 'double crystal Si(111)' _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.97939 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'CLSI BEAMLINE 08B1-1' _diffrn_source.pdbx_synchrotron_site CLSI _diffrn_source.pdbx_synchrotron_beamline 08B1-1 _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list 0.97939 # _reflns.entry_id 4OBS _reflns.observed_criterion_sigma_I -3.0 _reflns.observed_criterion_sigma_F ? _reflns.d_resolution_low 48.07 _reflns.d_resolution_high 2.26 _reflns.number_obs 30055 _reflns.number_all 30637 _reflns.percent_possible_obs 98.1 _reflns.pdbx_Rmerge_I_obs ? _reflns.pdbx_Rsym_value 0.065 _reflns.pdbx_netI_over_sigmaI 31.30 _reflns.B_iso_Wilson_estimate 18.79 _reflns.pdbx_redundancy 9.65 _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # _reflns_shell.d_res_high 2.26 _reflns_shell.d_res_low 2.319 _reflns_shell.percent_possible_all 85.0 _reflns_shell.Rmerge_I_obs ? _reflns_shell.pdbx_Rsym_value 0.242 _reflns_shell.meanI_over_sigI_obs 8.35 _reflns_shell.pdbx_redundancy 6.50 _reflns_shell.percent_possible_obs ? _reflns_shell.number_unique_all 2252 _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_unique_obs ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 # _refine.entry_id 4OBS _refine.ls_number_reflns_obs 30055 _refine.ls_number_reflns_all 30637 _refine.pdbx_ls_sigma_I -3.0 _refine.pdbx_ls_sigma_F ? _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 48.07 _refine.ls_d_res_high 2.26 _refine.ls_percent_reflns_obs 98.12 _refine.ls_R_factor_obs 0.19424 _refine.ls_R_factor_all 0.19424 _refine.ls_R_factor_R_work 0.19210 _refine.ls_R_factor_R_free 0.23522 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 5.0 _refine.ls_number_reflns_R_free 1503 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc 0.933 _refine.correlation_coeff_Fo_to_Fc_free 0.904 _refine.B_iso_mean 17.692 _refine.aniso_B[1][1] -1.01 _refine.aniso_B[2][2] 1.79 _refine.aniso_B[3][3] -0.78 _refine.aniso_B[1][2] 0.00 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_details MASK _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.20 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details 'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' _refine.pdbx_starting_model 'PDB ENTRY 4MJ2' _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R 0.347 _refine.pdbx_overall_ESU_R_Free 0.229 _refine.overall_SU_ML 0.142 _refine.pdbx_overall_phase_error ? _refine.overall_SU_B 5.634 _refine.overall_SU_R_Cruickshank_DPI ? _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_diffrn_id 1 _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 4724 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 142 _refine_hist.number_atoms_solvent 143 _refine_hist.number_atoms_total 5009 _refine_hist.d_res_high 2.26 _refine_hist.d_res_low 48.07 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_restraint_function _refine_ls_restr.pdbx_refine_id r_bond_refined_d 0.005 0.019 ? 5072 ? 'X-RAY DIFFRACTION' r_bond_other_d 0.001 0.020 ? 4726 ? 'X-RAY DIFFRACTION' r_angle_refined_deg 1.094 1.979 ? 6935 ? 'X-RAY DIFFRACTION' r_angle_other_deg 0.712 3.000 ? 10811 ? 'X-RAY DIFFRACTION' r_dihedral_angle_1_deg 6.274 5.000 ? 602 ? 'X-RAY DIFFRACTION' r_dihedral_angle_2_deg 32.777 22.137 ? 234 ? 'X-RAY DIFFRACTION' r_dihedral_angle_3_deg 13.178 15.000 ? 742 ? 'X-RAY DIFFRACTION' r_dihedral_angle_4_deg 17.868 15.000 ? 50 ? 'X-RAY DIFFRACTION' r_chiral_restr 0.061 0.200 ? 765 ? 'X-RAY DIFFRACTION' r_gen_planes_refined 0.003 0.021 ? 5667 ? 'X-RAY DIFFRACTION' r_gen_planes_other 0.001 0.020 ? 1239 ? 'X-RAY DIFFRACTION' # _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.d_res_high 2.260 _refine_ls_shell.d_res_low 2.319 _refine_ls_shell.number_reflns_R_work 1814 _refine_ls_shell.R_factor_R_work 0.215 _refine_ls_shell.percent_reflns_obs 85.0 _refine_ls_shell.R_factor_R_free 0.311 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.number_reflns_R_free 95 _refine_ls_shell.number_reflns_all ? _refine_ls_shell.R_factor_all ? _refine_ls_shell.number_reflns_obs 12438 _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' # _struct.entry_id 4OBS _struct.title 'Crystal structure of human alpha-L-iduronidase in the P212121 form' _struct.pdbx_descriptor 'Alpha-L-iduronidase (E.C.3.2.1.76)' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 4OBS _struct_keywords.pdbx_keywords HYDROLASE _struct_keywords.text 'glycoside hydrolase family 39, TIM barrel, beta sandwich, fibronectin III domain, glycosaminoglycans, HYDROLASE' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 2 ? D N N 2 ? E N N 2 ? F N N 3 ? G N N 4 ? H N N 4 ? I N N 4 ? J N N 5 ? K N N 5 ? L N N 5 ? M N N 5 ? N N N 5 ? O N N 5 ? P N N 6 ? Q N N 7 ? R N N 8 ? # _struct_biol.id 1 _struct_biol.details ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 PRO A 37 ? LEU A 40 ? PRO A 63 LEU A 66 5 ? 4 HELX_P HELX_P2 2 SER A 41 ? ALA A 53 ? SER A 67 ALA A 79 1 ? 13 HELX_P HELX_P3 3 VAL A 54 ? GLY A 58 ? VAL A 80 GLY A 84 5 ? 5 HELX_P HELX_P4 4 TRP A 66 ? LEU A 70 ? TRP A 92 LEU A 96 5 ? 5 HELX_P HELX_P5 5 PHE A 85 ? ASN A 98 ? PHE A 111 ASN A 124 1 ? 14 HELX_P HELX_P6 6 ASP A 119 ? GLY A 142 ? ASP A 145 GLY A 168 1 ? 24 HELX_P HELX_P7 7 GLY A 142 ? SER A 147 ? GLY A 168 SER A 173 1 ? 6 HELX_P HELX_P8 8 GLU A 156 ? HIS A 160 ? GLU A 182 HIS A 186 5 ? 5 HELX_P HELX_P9 9 THR A 168 ? SER A 187 ? THR A 194 SER A 213 1 ? 20 HELX_P HELX_P10 10 SER A 205 ? GLY A 218 ? SER A 231 GLY A 244 1 ? 14 HELX_P HELX_P11 11 SER A 242 ? PHE A 261 ? SER A 268 PHE A 287 1 ? 20 HELX_P HELX_P12 12 PRO A 262 ? ALA A 265 ? PRO A 288 ALA A 291 5 ? 4 HELX_P HELX_P13 13 GLN A 284 ? ALA A 288 ? GLN A 310 ALA A 314 5 ? 5 HELX_P HELX_P14 14 ASP A 289 ? LEU A 307 ? ASP A 315 LEU A 333 1 ? 19 HELX_P HELX_P15 15 LYS A 358 ? LEU A 369 ? LYS A 384 LEU A 395 1 ? 12 HELX_P HELX_P16 16 SER A 456 ? LEU A 464 ? SER A 482 LEU A 490 1 ? 9 HELX_P HELX_P17 17 THR A 471 ? ALA A 480 ? THR A 497 ALA A 506 1 ? 10 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 515 SG A ? ? 1_555 A CYS 551 SG A ? A CYS 541 A CYS 577 1_555 ? ? ? ? ? ? ? 2.038 ? covale1 covale ? ? E NAG . O4 ? ? ? 1_555 F BMA . C1 ? ? A NAG 904 A BMA 905 1_555 ? ? ? ? ? ? ? 1.435 ? covale2 covale ? ? D NAG . O4 ? ? ? 1_555 E NAG . C1 ? ? A NAG 903 A NAG 904 1_555 ? ? ? ? ? ? ? 1.437 ? covale3 covale ? ? F BMA . O6 ? ? ? 1_555 G MAN . C1 ? ? A BMA 905 A MAN 906 1_555 ? ? ? ? ? ? ? 1.440 ? covale4 covale ? ? F BMA . O3 ? ? ? 1_555 H MAN . C1 ? ? A BMA 905 A MAN 907 1_555 ? ? ? ? ? ? ? 1.446 ? covale5 covale ? ? A ASN 346 ND2 ? ? ? 1_555 D NAG . C1 ? ? A ASN 372 A NAG 903 1_555 ? ? ? ? ? ? ? 1.450 ? covale6 covale ? ? H MAN . O2 ? ? ? 1_555 I MAN . C1 ? ? A MAN 907 A MAN 908 1_555 ? ? ? ? ? ? ? 1.451 ? covale7 covale ? ? A ASN 389 ND2 ? ? ? 1_555 C NAG . C1 ? ? A ASN 415 A NAG 902 1_555 ? ? ? ? ? ? ? 1.453 ? covale8 covale ? ? A ASN 84 ND2 ? ? ? 1_555 B NAG . C1 ? ? A ASN 110 A NAG 901 1_555 ? ? ? ? ? ? ? 1.454 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 GLY 194 A . ? GLY 220 A PRO 195 A ? PRO 221 A 1 -0.87 2 PRO 202 A . ? PRO 228 A PRO 203 A ? PRO 229 A 1 13.71 3 HIS 330 A . ? HIS 356 A PRO 331 A ? PRO 357 A 1 5.44 4 ARG 349 A . ? ARG 375 A PRO 350 A ? PRO 376 A 1 -2.76 5 LEU 506 A . ? LEU 532 A PRO 507 A ? PRO 533 A 1 5.27 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 5 ? B ? 7 ? C ? 3 ? D ? 9 ? E ? 3 ? F ? 9 ? G ? 2 ? H ? 3 ? I ? 4 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? anti-parallel A 2 3 ? parallel A 3 4 ? anti-parallel A 4 5 ? anti-parallel B 1 2 ? anti-parallel B 2 3 ? anti-parallel B 3 4 ? anti-parallel B 4 5 ? anti-parallel B 5 6 ? anti-parallel B 6 7 ? anti-parallel C 1 2 ? anti-parallel C 2 3 ? anti-parallel D 1 2 ? anti-parallel D 2 3 ? anti-parallel D 3 4 ? anti-parallel D 4 5 ? anti-parallel D 5 6 ? anti-parallel D 6 7 ? anti-parallel D 7 8 ? parallel D 8 9 ? anti-parallel E 1 2 ? anti-parallel E 2 3 ? anti-parallel F 1 2 ? parallel F 2 3 ? parallel F 3 4 ? parallel F 4 5 ? parallel F 5 6 ? parallel F 6 7 ? parallel F 7 8 ? parallel F 8 9 ? parallel G 1 2 ? anti-parallel H 1 2 ? anti-parallel H 2 3 ? anti-parallel I 1 2 ? anti-parallel I 2 3 ? anti-parallel I 3 4 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 LEU A 498 ? LEU A 500 ? LEU A 524 LEU A 526 A 2 HIS A 423 ? ARG A 435 ? HIS A 449 ARG A 461 A 3 HIS A 4 ? PRO A 16 ? HIS A 30 PRO A 42 A 4 GLU A 373 ? GLN A 381 ? GLU A 399 GLN A 407 A 5 THR A 384 ? LEU A 386 ? THR A 410 LEU A 412 B 1 THR A 384 ? LEU A 386 ? THR A 410 LEU A 412 B 2 GLU A 373 ? GLN A 381 ? GLU A 399 GLN A 407 B 3 VAL A 392 ? HIS A 399 ? VAL A 418 HIS A 425 B 4 ARG A 409 ? ALA A 416 ? ARG A 435 ALA A 442 B 5 SER A 508 ? CYS A 515 ? SER A 534 CYS A 541 B 6 VAL A 444 ? ASP A 451 ? VAL A 470 ASP A 477 B 7 VAL A 485 ? ALA A 486 ? VAL A 511 ALA A 512 C 1 VAL A 485 ? ALA A 486 ? VAL A 511 ALA A 512 C 2 VAL A 444 ? ASP A 451 ? VAL A 470 ASP A 477 C 3 ARG A 490 ? PRO A 491 ? ARG A 516 PRO A 517 D 1 ARG A 490 ? PRO A 491 ? ARG A 516 PRO A 517 D 2 VAL A 444 ? ASP A 451 ? VAL A 470 ASP A 477 D 3 SER A 508 ? CYS A 515 ? SER A 534 CYS A 541 D 4 ARG A 409 ? ALA A 416 ? ARG A 435 ALA A 442 D 5 VAL A 392 ? HIS A 399 ? VAL A 418 HIS A 425 D 6 GLU A 373 ? GLN A 381 ? GLU A 399 GLN A 407 D 7 HIS A 4 ? PRO A 16 ? HIS A 30 PRO A 42 D 8 HIS A 423 ? ARG A 435 ? HIS A 449 ARG A 461 D 9 ALA A 503 ? LEU A 506 ? ALA A 529 LEU A 532 E 1 ALA A 503 ? LEU A 506 ? ALA A 529 LEU A 532 E 2 HIS A 423 ? ARG A 435 ? HIS A 449 ARG A 461 E 3 LEU A 498 ? LEU A 500 ? LEU A 524 LEU A 526 F 1 SER A 23 ? PHE A 26 ? SER A 49 PHE A 52 F 2 GLN A 61 ? THR A 64 ? GLN A 87 THR A 90 F 3 LEU A 101 ? GLU A 105 ? LEU A 127 GLU A 131 F 4 ASN A 150 ? GLU A 152 ? ASN A 176 GLU A 178 F 5 ARG A 191 ? ASP A 197 ? ARG A 217 ASP A 223 F 6 TYR A 232 ? LEU A 235 ? TYR A 258 LEU A 261 F 7 ILE A 269 ? ASN A 271 ? ILE A 295 ASN A 297 F 8 TYR A 317 ? ASN A 322 ? TYR A 343 ASN A 348 F 9 SER A 23 ? PHE A 26 ? SER A 49 PHE A 52 G 1 THR A 340 ? VAL A 345 ? THR A 366 VAL A 371 G 2 HIS A 352 ? ARG A 357 ? HIS A 378 ARG A 383 H 1 THR A 526 ? THR A 534 ? THR A 552 THR A 560 H 2 GLN A 537 ? SER A 543 ? GLN A 563 SER A 569 H 3 LEU A 578 ? PHE A 581 ? LEU A 604 PHE A 607 I 1 THR A 567 ? PRO A 568 ? THR A 593 PRO A 594 I 2 LEU A 552 ? SER A 560 ? LEU A 578 SER A 586 I 3 GLY A 590 ? ASP A 598 ? GLY A 616 ASP A 624 I 4 VAL A 610 ? TYR A 612 ? VAL A 636 TYR A 638 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 O LEU A 500 ? O LEU A 526 N LEU A 432 ? N LEU A 458 A 2 3 O ARG A 435 ? O ARG A 461 N ALA A 10 ? N ALA A 36 A 3 4 N LEU A 5 ? N LEU A 31 O SER A 380 ? O SER A 406 A 4 5 N VAL A 379 ? N VAL A 405 O LEU A 386 ? O LEU A 412 B 1 2 O LEU A 386 ? O LEU A 412 N VAL A 379 ? N VAL A 405 B 2 3 N GLU A 373 ? N GLU A 399 O ALA A 398 ? O ALA A 424 B 3 4 N LEU A 395 ? N LEU A 421 O LEU A 413 ? O LEU A 439 B 4 5 N ILE A 414 ? N ILE A 440 O LEU A 510 ? O LEU A 536 B 5 6 O HIS A 513 ? O HIS A 539 N VAL A 446 ? N VAL A 472 B 6 7 N TYR A 449 ? N TYR A 475 O VAL A 485 ? O VAL A 511 C 1 2 O VAL A 485 ? O VAL A 511 N TYR A 449 ? N TYR A 475 C 2 3 N TYR A 445 ? N TYR A 471 O ARG A 490 ? O ARG A 516 D 1 2 O ARG A 490 ? O ARG A 516 N TYR A 445 ? N TYR A 471 D 2 3 N VAL A 446 ? N VAL A 472 O HIS A 513 ? O HIS A 539 D 3 4 O LEU A 510 ? O LEU A 536 N ILE A 414 ? N ILE A 440 D 4 5 O LEU A 413 ? O LEU A 439 N LEU A 395 ? N LEU A 421 D 5 6 O ALA A 398 ? O ALA A 424 N GLU A 373 ? N GLU A 399 D 6 7 O SER A 380 ? O SER A 406 N LEU A 5 ? N LEU A 31 D 7 8 N ALA A 10 ? N ALA A 36 O ARG A 435 ? O ARG A 461 D 8 9 N VAL A 428 ? N VAL A 454 O LEU A 504 ? O LEU A 530 E 1 2 O LEU A 504 ? O LEU A 530 N VAL A 428 ? N VAL A 454 E 2 3 N LEU A 432 ? N LEU A 458 O LEU A 500 ? O LEU A 526 F 1 2 N THR A 24 ? N THR A 50 O ARG A 63 ? O ARG A 89 F 2 3 N VAL A 62 ? N VAL A 88 O LEU A 101 ? O LEU A 127 F 3 4 N PHE A 104 ? N PHE A 130 O GLU A 152 ? O GLU A 178 F 4 5 N PHE A 151 ? N PHE A 177 O GLY A 193 ? O GLY A 219 F 5 6 N GLY A 196 ? N GLY A 222 O SER A 234 ? O SER A 260 F 6 7 N LEU A 235 ? N LEU A 261 O TYR A 270 ? O TYR A 296 F 7 8 N ILE A 269 ? N ILE A 295 O ALA A 318 ? O ALA A 344 F 8 9 O ASN A 322 ? O ASN A 348 N SER A 23 ? N SER A 49 G 1 2 N PHE A 343 ? N PHE A 369 O GLN A 354 ? O GLN A 380 H 1 2 N THR A 526 ? N THR A 552 O SER A 543 ? O SER A 569 H 2 3 N LEU A 540 ? N LEU A 566 O PHE A 579 ? O PHE A 605 I 1 2 O THR A 567 ? O THR A 593 N PHE A 559 ? N PHE A 585 I 2 3 N GLN A 558 ? N GLN A 584 O ARG A 593 ? O ARG A 619 I 3 4 N TYR A 592 ? N TYR A 618 O VAL A 610 ? O VAL A 636 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 7 'BINDING SITE FOR RESIDUE GOL A 909' AC2 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE GOL A 910' AC3 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE GOL A 911' AC4 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE GOL A 912' AC5 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE GOL A 913' AC6 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE GOL A 914' AC7 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE CL A 915' AC8 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE SO4 A 916' AC9 Software ? ? ? ? 3 'BINDING SITE FOR MONO-SACCHARIDE NAG A 901 BOUND TO ASN A 110' BC1 Software ? ? ? ? 12 'BINDING SITE FOR CHAIN A OF SUGAR BOUND TO ASN A 372 RESIDUES 903 TO 908' BC2 Software ? ? ? ? 2 'BINDING SITE FOR MONO-SACCHARIDE NAG A 902 BOUND TO ASN A 415' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 7 TRP A 15 ? TRP A 41 . ? 1_555 ? 2 AC1 7 ALA A 309 ? ALA A 335 . ? 1_555 ? 3 AC1 7 LEU A 375 ? LEU A 401 . ? 1_555 ? 4 AC1 7 TRP A 376 ? TRP A 402 . ? 1_555 ? 5 AC1 7 ALA A 377 ? ALA A 403 . ? 1_555 ? 6 AC1 7 HOH R . ? HOH A 1097 . ? 1_555 ? 7 AC1 7 HOH R . ? HOH A 1113 . ? 1_555 ? 8 AC2 6 GLN A 45 ? GLN A 71 . ? 1_555 ? 9 AC2 6 ALA A 49 ? ALA A 75 . ? 1_555 ? 10 AC2 6 LEU A 94 ? LEU A 120 . ? 1_555 ? 11 AC2 6 GLU A 97 ? GLU A 123 . ? 1_555 ? 12 AC2 6 ASN A 98 ? ASN A 124 . ? 1_555 ? 13 AC2 6 ARG A 529 ? ARG A 555 . ? 1_555 ? 14 AC3 6 GLN A 121 ? GLN A 147 . ? 3_545 ? 15 AC3 6 PHE A 124 ? PHE A 150 . ? 3_545 ? 16 AC3 6 THR A 526 ? THR A 552 . ? 1_555 ? 17 AC3 6 ARG A 527 ? ARG A 553 . ? 1_555 ? 18 AC3 6 LEU A 528 ? LEU A 554 . ? 1_555 ? 19 AC3 6 HOH R . ? HOH A 1052 . ? 1_555 ? 20 AC4 4 VAL A 468 ? VAL A 494 . ? 1_555 ? 21 AC4 4 PHE A 469 ? PHE A 495 . ? 1_555 ? 22 AC4 4 ALA A 601 ? ALA A 627 . ? 3_455 ? 23 AC4 4 HOH R . ? HOH A 1110 . ? 1_555 ? 24 AC5 5 LYS A 298 ? LYS A 324 . ? 1_555 ? 25 AC5 5 HIS A 390 ? HIS A 416 . ? 1_555 ? 26 AC5 5 ASP A 418 ? ASP A 444 . ? 1_555 ? 27 AC5 5 ASP A 419 ? ASP A 445 . ? 1_555 ? 28 AC5 5 HOH R . ? HOH A 1071 . ? 1_555 ? 29 AC6 6 PRO A 331 ? PRO A 357 . ? 3_445 ? 30 AC6 6 GLU A 556 ? GLU A 582 . ? 1_555 ? 31 AC6 6 SER A 570 ? SER A 596 . ? 1_555 ? 32 AC6 6 ARG A 571 ? ARG A 597 . ? 1_555 ? 33 AC6 6 HOH R . ? HOH A 1112 . ? 1_555 ? 34 AC6 6 HOH R . ? HOH A 1119 . ? 1_555 ? 35 AC7 5 PRO A 276 ? PRO A 302 . ? 1_555 ? 36 AC7 5 LEU A 277 ? LEU A 303 . ? 1_555 ? 37 AC7 5 TRP A 286 ? TRP A 312 . ? 1_555 ? 38 AC7 5 ARG A 287 ? ARG A 313 . ? 1_555 ? 39 AC7 5 ARG A 337 ? ARG A 363 . ? 1_555 ? 40 AC8 3 ARG A 22 ? ARG A 48 . ? 1_555 ? 41 AC8 3 ARG A 57 ? ARG A 83 . ? 1_555 ? 42 AC8 3 LYS A 60 ? LYS A 86 . ? 1_555 ? 43 AC9 3 ASN A 84 ? ASN A 110 . ? 1_555 ? 44 AC9 3 THR A 86 ? THR A 112 . ? 1_555 ? 45 AC9 3 HIS A 87 ? HIS A 113 . ? 1_555 ? 46 BC1 12 SER A 281 ? SER A 307 . ? 1_555 ? 47 BC1 12 PRO A 283 ? PRO A 309 . ? 1_555 ? 48 BC1 12 TYR A 329 ? TYR A 355 . ? 1_555 ? 49 BC1 12 HIS A 330 ? HIS A 356 . ? 1_555 ? 50 BC1 12 GLN A 344 ? GLN A 370 . ? 1_555 ? 51 BC1 12 ASN A 346 ? ASN A 372 . ? 1_555 ? 52 BC1 12 VAL A 468 ? VAL A 494 . ? 1_555 ? 53 BC1 12 PHE A 469 ? PHE A 495 . ? 1_555 ? 54 BC1 12 SER A 570 ? SER A 596 . ? 3_455 ? 55 BC1 12 ARG A 571 ? ARG A 597 . ? 3_455 ? 56 BC1 12 LYS A 572 ? LYS A 598 . ? 3_455 ? 57 BC1 12 HOH R . ? HOH A 1067 . ? 1_555 ? 58 BC2 2 GLU A 248 ? GLU A 274 . ? 1_555 ? 59 BC2 2 ASN A 389 ? ASN A 415 . ? 1_555 ? # _database_PDB_matrix.entry_id 4OBS _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 4OBS _atom_sites.fract_transf_matrix[1][1] 0.013767 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.012816 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.008892 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C CL N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . ALA A 1 2 ? -45.621 -13.545 -7.035 1.00 27.88 ? 28 ALA A N 1 ATOM 2 C CA . ALA A 1 2 ? -45.082 -14.793 -7.671 1.00 27.64 ? 28 ALA A CA 1 ATOM 3 C C . ALA A 1 2 ? -44.052 -15.478 -6.761 1.00 26.93 ? 28 ALA A C 1 ATOM 4 O O . ALA A 1 2 ? -43.289 -14.798 -6.076 1.00 27.31 ? 28 ALA A O 1 ATOM 5 C CB . ALA A 1 2 ? -44.462 -14.480 -9.025 1.00 27.59 ? 28 ALA A CB 1 ATOM 6 N N . PRO A 1 3 ? -44.019 -16.825 -6.762 1.00 25.80 ? 29 PRO A N 1 ATOM 7 C CA . PRO A 1 3 ? -43.125 -17.559 -5.863 1.00 25.09 ? 29 PRO A CA 1 ATOM 8 C C . PRO A 1 3 ? -41.636 -17.424 -6.207 1.00 23.93 ? 29 PRO A C 1 ATOM 9 O O . PRO A 1 3 ? -41.276 -17.222 -7.368 1.00 25.14 ? 29 PRO A O 1 ATOM 10 C CB . PRO A 1 3 ? -43.581 -19.012 -6.026 1.00 25.39 ? 29 PRO A CB 1 ATOM 11 C CG . PRO A 1 3 ? -44.165 -19.073 -7.393 1.00 25.53 ? 29 PRO A CG 1 ATOM 12 C CD . PRO A 1 3 ? -44.797 -17.731 -7.628 1.00 25.68 ? 29 PRO A CD 1 ATOM 13 N N . HIS A 1 4 ? -40.791 -17.535 -5.188 1.00 22.29 ? 30 HIS A N 1 ATOM 14 C CA . HIS A 1 4 ? -39.341 -17.468 -5.355 1.00 20.77 ? 30 HIS A CA 1 ATOM 15 C C . HIS A 1 4 ? -38.766 -18.870 -5.527 1.00 19.75 ? 30 HIS A C 1 ATOM 16 O O . HIS A 1 4 ? -39.118 -19.789 -4.793 1.00 19.24 ? 30 HIS A O 1 ATOM 17 C CB . HIS A 1 4 ? -38.698 -16.787 -4.147 1.00 20.27 ? 30 HIS A CB 1 ATOM 18 C CG . HIS A 1 4 ? -38.832 -15.296 -4.152 1.00 20.08 ? 30 HIS A CG 1 ATOM 19 N ND1 . HIS A 1 4 ? -40.004 -14.650 -3.817 1.00 19.71 ? 30 HIS A ND1 1 ATOM 20 C CD2 . HIS A 1 4 ? -37.935 -14.323 -4.442 1.00 19.52 ? 30 HIS A CD2 1 ATOM 21 C CE1 . HIS A 1 4 ? -39.823 -13.343 -3.905 1.00 19.52 ? 30 HIS A CE1 1 ATOM 22 N NE2 . HIS A 1 4 ? -38.577 -13.119 -4.279 1.00 19.58 ? 30 HIS A NE2 1 ATOM 23 N N . LEU A 1 5 ? -37.888 -19.025 -6.509 1.00 18.86 ? 31 LEU A N 1 ATOM 24 C CA . LEU A 1 5 ? -37.224 -20.293 -6.756 1.00 18.45 ? 31 LEU A CA 1 ATOM 25 C C . LEU A 1 5 ? -35.760 -20.161 -6.348 1.00 17.99 ? 31 LEU A C 1 ATOM 26 O O . LEU A 1 5 ? -35.048 -19.324 -6.896 1.00 17.85 ? 31 LEU A O 1 ATOM 27 C CB . LEU A 1 5 ? -37.346 -20.661 -8.235 1.00 18.51 ? 31 LEU A CB 1 ATOM 28 C CG . LEU A 1 5 ? -36.634 -21.919 -8.729 1.00 18.72 ? 31 LEU A CG 1 ATOM 29 C CD1 . LEU A 1 5 ? -37.128 -23.150 -7.990 1.00 18.79 ? 31 LEU A CD1 1 ATOM 30 C CD2 . LEU A 1 5 ? -36.833 -22.077 -10.231 1.00 19.04 ? 31 LEU A CD2 1 ATOM 31 N N . VAL A 1 6 ? -35.330 -20.970 -5.377 1.00 17.53 ? 32 VAL A N 1 ATOM 32 C CA . VAL A 1 6 ? -33.937 -20.978 -4.915 1.00 17.61 ? 32 VAL A CA 1 ATOM 33 C C . VAL A 1 6 ? -33.262 -22.289 -5.320 1.00 17.74 ? 32 VAL A C 1 ATOM 34 O O . VAL A 1 6 ? -33.605 -23.357 -4.800 1.00 17.27 ? 32 VAL A O 1 ATOM 35 C CB . VAL A 1 6 ? -33.834 -20.817 -3.380 1.00 17.41 ? 32 VAL A CB 1 ATOM 36 C CG1 . VAL A 1 6 ? -32.374 -20.847 -2.929 1.00 17.34 ? 32 VAL A CG1 1 ATOM 37 C CG2 . VAL A 1 6 ? -34.501 -19.529 -2.928 1.00 17.37 ? 32 VAL A CG2 1 ATOM 38 N N . GLN A 1 7 ? -32.301 -22.199 -6.237 1.00 17.82 ? 33 GLN A N 1 ATOM 39 C CA . GLN A 1 7 ? -31.584 -23.370 -6.741 1.00 18.06 ? 33 GLN A CA 1 ATOM 40 C C . GLN A 1 7 ? -30.176 -23.413 -6.170 1.00 17.91 ? 33 GLN A C 1 ATOM 41 O O . GLN A 1 7 ? -29.501 -22.396 -6.123 1.00 18.41 ? 33 GLN A O 1 ATOM 42 C CB . GLN A 1 7 ? -31.514 -23.339 -8.267 1.00 18.79 ? 33 GLN A CB 1 ATOM 43 C CG . GLN A 1 7 ? -32.867 -23.131 -8.925 1.00 19.37 ? 33 GLN A CG 1 ATOM 44 C CD . GLN A 1 7 ? -32.808 -23.230 -10.431 1.00 19.77 ? 33 GLN A CD 1 ATOM 45 O OE1 . GLN A 1 7 ? -32.728 -22.223 -11.135 1.00 19.97 ? 33 GLN A OE1 1 ATOM 46 N NE2 . GLN A 1 7 ? -32.849 -24.446 -10.934 1.00 20.26 ? 33 GLN A NE2 1 ATOM 47 N N . VAL A 1 8 ? -29.746 -24.593 -5.730 1.00 17.56 ? 34 VAL A N 1 ATOM 48 C CA . VAL A 1 8 ? -28.422 -24.777 -5.146 1.00 17.21 ? 34 VAL A CA 1 ATOM 49 C C . VAL A 1 8 ? -27.795 -26.016 -5.767 1.00 17.38 ? 34 VAL A C 1 ATOM 50 O O . VAL A 1 8 ? -28.413 -27.078 -5.783 1.00 17.21 ? 34 VAL A O 1 ATOM 51 C CB . VAL A 1 8 ? -28.500 -24.961 -3.611 1.00 17.05 ? 34 VAL A CB 1 ATOM 52 C CG1 . VAL A 1 8 ? -27.116 -25.226 -3.020 1.00 17.00 ? 34 VAL A CG1 1 ATOM 53 C CG2 . VAL A 1 8 ? -29.137 -23.739 -2.956 1.00 16.92 ? 34 VAL A CG2 1 ATOM 54 N N . ASP A 1 9 ? -26.575 -25.877 -6.277 1.00 17.63 ? 35 ASP A N 1 ATOM 55 C CA . ASP A 1 9 ? -25.832 -27.013 -6.815 1.00 18.12 ? 35 ASP A CA 1 ATOM 56 C C . ASP A 1 9 ? -24.640 -27.347 -5.922 1.00 18.25 ? 35 ASP A C 1 ATOM 57 O O . ASP A 1 9 ? -23.638 -26.623 -5.900 1.00 18.28 ? 35 ASP A O 1 ATOM 58 C CB . ASP A 1 9 ? -25.362 -26.745 -8.246 1.00 18.28 ? 35 ASP A CB 1 ATOM 59 C CG . ASP A 1 9 ? -24.750 -27.983 -8.905 1.00 18.63 ? 35 ASP A CG 1 ATOM 60 O OD1 . ASP A 1 9 ? -24.640 -29.042 -8.248 1.00 18.49 ? 35 ASP A OD1 1 ATOM 61 O OD2 . ASP A 1 9 ? -24.367 -27.894 -10.089 1.00 19.67 ? 35 ASP A OD2 1 ATOM 62 N N . ALA A 1 10 ? -24.752 -28.471 -5.221 1.00 18.56 ? 36 ALA A N 1 ATOM 63 C CA . ALA A 1 10 ? -23.734 -28.923 -4.272 1.00 19.24 ? 36 ALA A CA 1 ATOM 64 C C . ALA A 1 10 ? -22.541 -29.638 -4.919 1.00 19.82 ? 36 ALA A C 1 ATOM 65 O O . ALA A 1 10 ? -21.595 -29.994 -4.224 1.00 19.46 ? 36 ALA A O 1 ATOM 66 C CB . ALA A 1 10 ? -24.372 -29.832 -3.233 1.00 19.13 ? 36 ALA A CB 1 ATOM 67 N N . ALA A 1 11 ? -22.593 -29.858 -6.232 1.00 20.84 ? 37 ALA A N 1 ATOM 68 C CA . ALA A 1 11 ? -21.499 -30.512 -6.963 1.00 22.09 ? 37 ALA A CA 1 ATOM 69 C C . ALA A 1 11 ? -20.439 -29.511 -7.394 1.00 23.54 ? 37 ALA A C 1 ATOM 70 O O . ALA A 1 11 ? -19.404 -29.894 -7.931 1.00 24.42 ? 37 ALA A O 1 ATOM 71 C CB . ALA A 1 11 ? -22.047 -31.236 -8.188 1.00 21.85 ? 37 ALA A CB 1 ATOM 72 N N . ARG A 1 12 ? -20.693 -28.235 -7.112 1.00 25.24 ? 38 ARG A N 1 ATOM 73 C CA . ARG A 1 12 ? -20.052 -27.116 -7.784 1.00 26.87 ? 38 ARG A CA 1 ATOM 74 C C . ARG A 1 12 ? -19.504 -26.116 -6.752 1.00 25.89 ? 38 ARG A C 1 ATOM 75 O O . ARG A 1 12 ? -20.159 -25.121 -6.427 1.00 26.03 ? 38 ARG A O 1 ATOM 76 C CB . ARG A 1 12 ? -21.112 -26.460 -8.683 1.00 28.66 ? 38 ARG A CB 1 ATOM 77 C CG . ARG A 1 12 ? -20.627 -25.468 -9.723 1.00 30.38 ? 38 ARG A CG 1 ATOM 78 C CD . ARG A 1 12 ? -21.788 -25.095 -10.639 1.00 31.89 ? 38 ARG A CD 1 ATOM 79 N NE . ARG A 1 12 ? -21.493 -23.956 -11.508 1.00 33.86 ? 38 ARG A NE 1 ATOM 80 C CZ . ARG A 1 12 ? -22.340 -23.445 -12.403 1.00 35.40 ? 38 ARG A CZ 1 ATOM 81 N NH1 . ARG A 1 12 ? -23.555 -23.966 -12.569 1.00 35.84 ? 38 ARG A NH1 1 ATOM 82 N NH2 . ARG A 1 12 ? -21.970 -22.406 -13.143 1.00 36.48 ? 38 ARG A NH2 1 ATOM 83 N N . ALA A 1 13 ? -18.317 -26.418 -6.227 1.00 24.89 ? 39 ALA A N 1 ATOM 84 C CA . ALA A 1 13 ? -17.573 -25.520 -5.335 1.00 24.62 ? 39 ALA A CA 1 ATOM 85 C C . ALA A 1 13 ? -16.835 -24.459 -6.147 1.00 24.13 ? 39 ALA A C 1 ATOM 86 O O . ALA A 1 13 ? -15.913 -24.780 -6.889 1.00 24.33 ? 39 ALA A O 1 ATOM 87 C CB . ALA A 1 13 ? -16.580 -26.308 -4.502 1.00 24.35 ? 39 ALA A CB 1 ATOM 88 N N . LEU A 1 14 ? -17.227 -23.199 -5.988 1.00 23.42 ? 40 LEU A N 1 ATOM 89 C CA . LEU A 1 14 ? -16.725 -22.120 -6.838 1.00 23.31 ? 40 LEU A CA 1 ATOM 90 C C . LEU A 1 14 ? -15.422 -21.503 -6.326 1.00 23.34 ? 40 LEU A C 1 ATOM 91 O O . LEU A 1 14 ? -14.464 -21.365 -7.078 1.00 23.51 ? 40 LEU A O 1 ATOM 92 C CB . LEU A 1 14 ? -17.791 -21.031 -6.980 1.00 23.17 ? 40 LEU A CB 1 ATOM 93 C CG . LEU A 1 14 ? -19.140 -21.458 -7.564 1.00 23.35 ? 40 LEU A CG 1 ATOM 94 C CD1 . LEU A 1 14 ? -20.135 -20.316 -7.481 1.00 23.30 ? 40 LEU A CD1 1 ATOM 95 C CD2 . LEU A 1 14 ? -18.986 -21.923 -9.007 1.00 23.39 ? 40 LEU A CD2 1 ATOM 96 N N . TRP A 1 15 ? -15.400 -21.125 -5.051 1.00 23.18 ? 41 TRP A N 1 ATOM 97 C CA . TRP A 1 15 ? -14.287 -20.368 -4.470 1.00 23.19 ? 41 TRP A CA 1 ATOM 98 C C . TRP A 1 15 ? -14.459 -20.343 -2.952 1.00 22.78 ? 41 TRP A C 1 ATOM 99 O O . TRP A 1 15 ? -15.509 -20.755 -2.452 1.00 21.65 ? 41 TRP A O 1 ATOM 100 C CB . TRP A 1 15 ? -14.244 -18.931 -5.040 1.00 23.11 ? 41 TRP A CB 1 ATOM 101 C CG . TRP A 1 15 ? -15.604 -18.365 -5.297 1.00 23.65 ? 41 TRP A CG 1 ATOM 102 C CD1 . TRP A 1 15 ? -16.552 -18.058 -4.368 1.00 23.55 ? 41 TRP A CD1 1 ATOM 103 C CD2 . TRP A 1 15 ? -16.180 -18.062 -6.576 1.00 23.82 ? 41 TRP A CD2 1 ATOM 104 N NE1 . TRP A 1 15 ? -17.684 -17.586 -4.987 1.00 23.79 ? 41 TRP A NE1 1 ATOM 105 C CE2 . TRP A 1 15 ? -17.482 -17.579 -6.343 1.00 23.64 ? 41 TRP A CE2 1 ATOM 106 C CE3 . TRP A 1 15 ? -15.722 -18.161 -7.896 1.00 24.06 ? 41 TRP A CE3 1 ATOM 107 C CZ2 . TRP A 1 15 ? -18.330 -17.184 -7.378 1.00 23.78 ? 41 TRP A CZ2 1 ATOM 108 C CZ3 . TRP A 1 15 ? -16.565 -17.770 -8.924 1.00 24.03 ? 41 TRP A CZ3 1 ATOM 109 C CH2 . TRP A 1 15 ? -17.855 -17.285 -8.659 1.00 23.86 ? 41 TRP A CH2 1 ATOM 110 N N . PRO A 1 16 ? -13.437 -19.857 -2.215 1.00 22.94 ? 42 PRO A N 1 ATOM 111 C CA . PRO A 1 16 ? -13.555 -19.811 -0.760 1.00 22.73 ? 42 PRO A CA 1 ATOM 112 C C . PRO A 1 16 ? -14.701 -18.930 -0.286 1.00 22.75 ? 42 PRO A C 1 ATOM 113 O O . PRO A 1 16 ? -15.039 -17.939 -0.934 1.00 22.87 ? 42 PRO A O 1 ATOM 114 C CB . PRO A 1 16 ? -12.216 -19.218 -0.306 1.00 22.91 ? 42 PRO A CB 1 ATOM 115 C CG . PRO A 1 16 ? -11.275 -19.480 -1.427 1.00 23.12 ? 42 PRO A CG 1 ATOM 116 C CD . PRO A 1 16 ? -12.115 -19.379 -2.666 1.00 23.09 ? 42 PRO A CD 1 ATOM 117 N N . LEU A 1 17 ? -15.308 -19.325 0.826 1.00 22.70 ? 43 LEU A N 1 ATOM 118 C CA . LEU A 1 17 ? -16.252 -18.482 1.543 1.00 22.42 ? 43 LEU A CA 1 ATOM 119 C C . LEU A 1 17 ? -15.635 -18.224 2.906 1.00 21.68 ? 43 LEU A C 1 ATOM 120 O O . LEU A 1 17 ? -15.706 -19.067 3.798 1.00 22.25 ? 43 LEU A O 1 ATOM 121 C CB . LEU A 1 17 ? -17.614 -19.171 1.653 1.00 22.74 ? 43 LEU A CB 1 ATOM 122 C CG . LEU A 1 17 ? -18.710 -18.617 2.571 1.00 23.08 ? 43 LEU A CG 1 ATOM 123 C CD1 . LEU A 1 17 ? -18.648 -17.107 2.729 1.00 23.47 ? 43 LEU A CD1 1 ATOM 124 C CD2 . LEU A 1 17 ? -20.076 -19.045 2.041 1.00 23.33 ? 43 LEU A CD2 1 ATOM 125 N N . ARG A 1 18 ? -15.003 -17.063 3.041 1.00 20.91 ? 44 ARG A N 1 ATOM 126 C CA . ARG A 1 18 ? -14.372 -16.658 4.288 1.00 20.42 ? 44 ARG A CA 1 ATOM 127 C C . ARG A 1 18 ? -15.412 -16.085 5.244 1.00 18.58 ? 44 ARG A C 1 ATOM 128 O O . ARG A 1 18 ? -16.266 -15.289 4.844 1.00 17.91 ? 44 ARG A O 1 ATOM 129 C CB . ARG A 1 18 ? -13.283 -15.610 4.024 1.00 21.82 ? 44 ARG A CB 1 ATOM 130 C CG . ARG A 1 18 ? -12.142 -16.086 3.140 1.00 23.41 ? 44 ARG A CG 1 ATOM 131 C CD . ARG A 1 18 ? -11.161 -14.955 2.857 1.00 25.27 ? 44 ARG A CD 1 ATOM 132 N NE . ARG A 1 18 ? -10.185 -15.287 1.810 1.00 27.21 ? 44 ARG A NE 1 ATOM 133 C CZ . ARG A 1 18 ? -8.996 -15.856 2.018 1.00 29.30 ? 44 ARG A CZ 1 ATOM 134 N NH1 . ARG A 1 18 ? -8.600 -16.189 3.244 1.00 30.51 ? 44 ARG A NH1 1 ATOM 135 N NH2 . ARG A 1 18 ? -8.187 -16.103 0.986 1.00 30.28 ? 44 ARG A NH2 1 ATOM 136 N N . ARG A 1 19 ? -15.333 -16.483 6.510 1.00 16.84 ? 45 ARG A N 1 ATOM 137 C CA . ARG A 1 19 ? -16.234 -15.955 7.535 1.00 15.80 ? 45 ARG A CA 1 ATOM 138 C C . ARG A 1 19 ? -15.711 -14.590 8.011 1.00 14.65 ? 45 ARG A C 1 ATOM 139 O O . ARG A 1 19 ? -15.111 -14.451 9.078 1.00 14.43 ? 45 ARG A O 1 ATOM 140 C CB . ARG A 1 19 ? -16.402 -16.965 8.671 1.00 15.76 ? 45 ARG A CB 1 ATOM 141 C CG . ARG A 1 19 ? -16.818 -18.347 8.161 1.00 15.89 ? 45 ARG A CG 1 ATOM 142 C CD . ARG A 1 19 ? -17.331 -19.245 9.271 1.00 15.78 ? 45 ARG A CD 1 ATOM 143 N NE . ARG A 1 19 ? -16.302 -19.484 10.276 1.00 15.66 ? 45 ARG A NE 1 ATOM 144 C CZ . ARG A 1 19 ? -16.530 -19.923 11.511 1.00 15.80 ? 45 ARG A CZ 1 ATOM 145 N NH1 . ARG A 1 19 ? -17.763 -20.187 11.928 1.00 15.85 ? 45 ARG A NH1 1 ATOM 146 N NH2 . ARG A 1 19 ? -15.512 -20.092 12.343 1.00 15.79 ? 45 ARG A NH2 1 ATOM 147 N N . PHE A 1 20 ? -15.969 -13.585 7.182 1.00 13.49 ? 46 PHE A N 1 ATOM 148 C CA . PHE A 1 20 ? -15.400 -12.241 7.332 1.00 12.77 ? 46 PHE A CA 1 ATOM 149 C C . PHE A 1 20 ? -16.196 -11.326 8.267 1.00 12.32 ? 46 PHE A C 1 ATOM 150 O O . PHE A 1 20 ? -15.815 -10.175 8.477 1.00 12.00 ? 46 PHE A O 1 ATOM 151 C CB . PHE A 1 20 ? -15.303 -11.570 5.954 1.00 12.49 ? 46 PHE A CB 1 ATOM 152 C CG . PHE A 1 20 ? -16.631 -11.416 5.257 1.00 12.22 ? 46 PHE A CG 1 ATOM 153 C CD1 . PHE A 1 20 ? -17.483 -10.361 5.567 1.00 12.28 ? 46 PHE A CD1 1 ATOM 154 C CD2 . PHE A 1 20 ? -17.029 -12.322 4.293 1.00 12.21 ? 46 PHE A CD2 1 ATOM 155 C CE1 . PHE A 1 20 ? -18.700 -10.220 4.929 1.00 12.18 ? 46 PHE A CE1 1 ATOM 156 C CE2 . PHE A 1 20 ? -18.246 -12.189 3.649 1.00 12.19 ? 46 PHE A CE2 1 ATOM 157 C CZ . PHE A 1 20 ? -19.082 -11.133 3.966 1.00 12.24 ? 46 PHE A CZ 1 ATOM 158 N N . TRP A 1 21 ? -17.290 -11.847 8.818 1.00 11.97 ? 47 TRP A N 1 ATOM 159 C CA . TRP A 1 21 ? -18.280 -11.058 9.547 1.00 11.81 ? 47 TRP A CA 1 ATOM 160 C C . TRP A 1 21 ? -18.232 -11.290 11.058 1.00 11.86 ? 47 TRP A C 1 ATOM 161 O O . TRP A 1 21 ? -19.080 -10.781 11.795 1.00 11.70 ? 47 TRP A O 1 ATOM 162 C CB . TRP A 1 21 ? -19.684 -11.421 9.045 1.00 11.67 ? 47 TRP A CB 1 ATOM 163 C CG . TRP A 1 21 ? -19.966 -12.872 9.151 1.00 11.61 ? 47 TRP A CG 1 ATOM 164 C CD1 . TRP A 1 21 ? -20.366 -13.551 10.265 1.00 11.56 ? 47 TRP A CD1 1 ATOM 165 C CD2 . TRP A 1 21 ? -19.829 -13.847 8.112 1.00 11.58 ? 47 TRP A CD2 1 ATOM 166 N NE1 . TRP A 1 21 ? -20.499 -14.886 9.979 1.00 11.54 ? 47 TRP A NE1 1 ATOM 167 C CE2 . TRP A 1 21 ? -20.176 -15.096 8.664 1.00 11.52 ? 47 TRP A CE2 1 ATOM 168 C CE3 . TRP A 1 21 ? -19.451 -13.783 6.764 1.00 11.62 ? 47 TRP A CE3 1 ATOM 169 C CZ2 . TRP A 1 21 ? -20.163 -16.276 7.917 1.00 11.63 ? 47 TRP A CZ2 1 ATOM 170 C CZ3 . TRP A 1 21 ? -19.443 -14.955 6.018 1.00 11.68 ? 47 TRP A CZ3 1 ATOM 171 C CH2 . TRP A 1 21 ? -19.793 -16.187 6.600 1.00 11.63 ? 47 TRP A CH2 1 ATOM 172 N N . ARG A 1 22 ? -17.249 -12.052 11.527 1.00 11.88 ? 48 ARG A N 1 ATOM 173 C CA . ARG A 1 22 ? -17.273 -12.568 12.902 1.00 11.85 ? 48 ARG A CA 1 ATOM 174 C C . ARG A 1 22 ? -16.738 -11.543 13.905 1.00 11.94 ? 48 ARG A C 1 ATOM 175 O O . ARG A 1 22 ? -15.814 -11.817 14.671 1.00 11.77 ? 48 ARG A O 1 ATOM 176 C CB . ARG A 1 22 ? -16.499 -13.882 12.975 1.00 11.83 ? 48 ARG A CB 1 ATOM 177 C CG . ARG A 1 22 ? -17.017 -14.933 11.999 1.00 11.74 ? 48 ARG A CG 1 ATOM 178 C CD . ARG A 1 22 ? -16.274 -16.240 12.151 1.00 11.69 ? 48 ARG A CD 1 ATOM 179 N NE . ARG A 1 22 ? -14.872 -16.138 11.734 1.00 11.72 ? 48 ARG A NE 1 ATOM 180 C CZ . ARG A 1 22 ? -13.841 -16.740 12.333 1.00 11.46 ? 48 ARG A CZ 1 ATOM 181 N NH1 . ARG A 1 22 ? -14.008 -17.492 13.412 1.00 11.50 ? 48 ARG A NH1 1 ATOM 182 N NH2 . ARG A 1 22 ? -12.620 -16.580 11.851 1.00 11.42 ? 48 ARG A NH2 1 ATOM 183 N N . SER A 1 23 ? -17.344 -10.360 13.894 1.00 11.95 ? 49 SER A N 1 ATOM 184 C CA . SER A 1 23 ? -16.917 -9.265 14.750 1.00 11.99 ? 49 SER A CA 1 ATOM 185 C C . SER A 1 23 ? -18.101 -8.502 15.330 1.00 12.13 ? 49 SER A C 1 ATOM 186 O O . SER A 1 23 ? -19.189 -8.453 14.747 1.00 12.13 ? 49 SER A O 1 ATOM 187 C CB . SER A 1 23 ? -16.023 -8.299 13.973 1.00 11.88 ? 49 SER A CB 1 ATOM 188 O OG . SER A 1 23 ? -15.666 -7.186 14.771 1.00 11.70 ? 49 SER A OG 1 ATOM 189 N N . THR A 1 24 ? -17.868 -7.920 16.496 1.00 12.28 ? 50 THR A N 1 ATOM 190 C CA . THR A 1 24 ? -18.797 -6.995 17.106 1.00 12.69 ? 50 THR A CA 1 ATOM 191 C C . THR A 1 24 ? -17.987 -5.917 17.826 1.00 13.19 ? 50 THR A C 1 ATOM 192 O O . THR A 1 24 ? -16.751 -5.911 17.772 1.00 13.00 ? 50 THR A O 1 ATOM 193 C CB . THR A 1 24 ? -19.774 -7.704 18.081 1.00 12.67 ? 50 THR A CB 1 ATOM 194 O OG1 . THR A 1 24 ? -20.694 -6.746 18.619 1.00 12.55 ? 50 THR A OG1 1 ATOM 195 C CG2 . THR A 1 24 ? -19.035 -8.396 19.222 1.00 12.63 ? 50 THR A CG2 1 ATOM 196 N N . GLY A 1 25 ? -18.674 -5.001 18.491 1.00 13.69 ? 51 GLY A N 1 ATOM 197 C CA . GLY A 1 25 ? -17.980 -3.959 19.222 1.00 14.20 ? 51 GLY A CA 1 ATOM 198 C C . GLY A 1 25 ? -18.911 -3.134 20.072 1.00 14.82 ? 51 GLY A C 1 ATOM 199 O O . GLY A 1 25 ? -20.136 -3.282 19.984 1.00 14.71 ? 51 GLY A O 1 ATOM 200 N N . PHE A 1 26 ? -18.321 -2.270 20.895 1.00 15.40 ? 52 PHE A N 1 ATOM 201 C CA . PHE A 1 26 ? -19.080 -1.375 21.756 1.00 16.25 ? 52 PHE A CA 1 ATOM 202 C C . PHE A 1 26 ? -18.190 -0.275 22.344 1.00 16.96 ? 52 PHE A C 1 ATOM 203 O O . PHE A 1 26 ? -16.975 -0.276 22.148 1.00 16.69 ? 52 PHE A O 1 ATOM 204 C CB . PHE A 1 26 ? -19.785 -2.161 22.875 1.00 16.16 ? 52 PHE A CB 1 ATOM 205 C CG . PHE A 1 26 ? -18.875 -2.599 23.984 1.00 16.28 ? 52 PHE A CG 1 ATOM 206 C CD1 . PHE A 1 26 ? -18.163 -3.781 23.885 1.00 16.30 ? 52 PHE A CD1 1 ATOM 207 C CD2 . PHE A 1 26 ? -18.741 -1.830 25.133 1.00 16.44 ? 52 PHE A CD2 1 ATOM 208 C CE1 . PHE A 1 26 ? -17.325 -4.191 24.904 1.00 16.49 ? 52 PHE A CE1 1 ATOM 209 C CE2 . PHE A 1 26 ? -17.901 -2.233 26.155 1.00 16.55 ? 52 PHE A CE2 1 ATOM 210 C CZ . PHE A 1 26 ? -17.193 -3.415 26.042 1.00 16.54 ? 52 PHE A CZ 1 ATOM 211 N N . CYS A 1 27 ? -18.824 0.649 23.061 1.00 18.25 ? 53 CYS A N 1 ATOM 212 C CA . CYS A 1 27 ? -18.160 1.775 23.720 1.00 19.57 ? 53 CYS A CA 1 ATOM 213 C C . CYS A 1 27 ? -18.604 1.772 25.183 1.00 20.62 ? 53 CYS A C 1 ATOM 214 O O . CYS A 1 27 ? -19.800 1.791 25.452 1.00 20.52 ? 53 CYS A O 1 ATOM 215 C CB . CYS A 1 27 ? -18.564 3.091 23.050 1.00 19.80 ? 53 CYS A CB 1 ATOM 216 S SG . CYS A 1 27 ? -17.756 4.574 23.712 1.00 20.57 ? 53 CYS A SG 1 ATOM 217 N N . PRO A 1 28 ? -17.650 1.716 26.134 1.00 22.30 ? 54 PRO A N 1 ATOM 218 C CA . PRO A 1 28 ? -18.005 1.716 27.562 1.00 22.92 ? 54 PRO A CA 1 ATOM 219 C C . PRO A 1 28 ? -18.846 2.920 28.001 1.00 23.31 ? 54 PRO A C 1 ATOM 220 O O . PRO A 1 28 ? -18.744 3.986 27.400 1.00 23.44 ? 54 PRO A O 1 ATOM 221 C CB . PRO A 1 28 ? -16.642 1.743 28.264 1.00 23.08 ? 54 PRO A CB 1 ATOM 222 C CG . PRO A 1 28 ? -15.705 1.106 27.296 1.00 22.88 ? 54 PRO A CG 1 ATOM 223 C CD . PRO A 1 28 ? -16.209 1.462 25.926 1.00 22.70 ? 54 PRO A CD 1 ATOM 224 N N . PRO A 1 37 ? -14.830 -0.542 36.831 1.00 47.83 ? 63 PRO A N 1 ATOM 225 C CA . PRO A 1 37 ? -15.210 -0.118 35.481 1.00 46.74 ? 63 PRO A CA 1 ATOM 226 C C . PRO A 1 37 ? -16.471 -0.822 34.982 1.00 45.36 ? 63 PRO A C 1 ATOM 227 O O . PRO A 1 37 ? -16.800 -1.913 35.458 1.00 45.73 ? 63 PRO A O 1 ATOM 228 C CB . PRO A 1 37 ? -13.999 -0.519 34.632 1.00 47.03 ? 63 PRO A CB 1 ATOM 229 C CG . PRO A 1 37 ? -12.848 -0.509 35.580 1.00 47.33 ? 63 PRO A CG 1 ATOM 230 C CD . PRO A 1 37 ? -13.398 -0.877 36.932 1.00 47.23 ? 63 PRO A CD 1 ATOM 231 N N . TYR A 1 38 ? -17.164 -0.186 34.037 1.00 43.21 ? 64 TYR A N 1 ATOM 232 C CA . TYR A 1 38 ? -18.358 -0.756 33.392 1.00 42.25 ? 64 TYR A CA 1 ATOM 233 C C . TYR A 1 38 ? -18.012 -2.023 32.602 1.00 38.11 ? 64 TYR A C 1 ATOM 234 O O . TYR A 1 38 ? -18.803 -2.964 32.554 1.00 37.65 ? 64 TYR A O 1 ATOM 235 C CB . TYR A 1 38 ? -19.029 0.306 32.495 1.00 44.18 ? 64 TYR A CB 1 ATOM 236 C CG . TYR A 1 38 ? -19.863 -0.201 31.321 1.00 46.33 ? 64 TYR A CG 1 ATOM 237 C CD1 . TYR A 1 38 ? -19.260 -0.556 30.114 1.00 47.64 ? 64 TYR A CD1 1 ATOM 238 C CD2 . TYR A 1 38 ? -21.256 -0.273 31.400 1.00 47.73 ? 64 TYR A CD2 1 ATOM 239 C CE1 . TYR A 1 38 ? -20.012 -0.998 29.034 1.00 48.20 ? 64 TYR A CE1 1 ATOM 240 C CE2 . TYR A 1 38 ? -22.016 -0.712 30.320 1.00 48.67 ? 64 TYR A CE2 1 ATOM 241 C CZ . TYR A 1 38 ? -21.388 -1.073 29.138 1.00 48.72 ? 64 TYR A CZ 1 ATOM 242 O OH . TYR A 1 38 ? -22.121 -1.511 28.056 1.00 47.95 ? 64 TYR A OH 1 ATOM 243 N N . VAL A 1 39 ? -16.827 -2.037 31.994 1.00 34.65 ? 65 VAL A N 1 ATOM 244 C CA . VAL A 1 39 ? -16.340 -3.207 31.250 1.00 32.39 ? 65 VAL A CA 1 ATOM 245 C C . VAL A 1 39 ? -16.098 -4.451 32.124 1.00 29.79 ? 65 VAL A C 1 ATOM 246 O O . VAL A 1 39 ? -16.042 -5.563 31.604 1.00 27.64 ? 65 VAL A O 1 ATOM 247 C CB . VAL A 1 39 ? -15.050 -2.895 30.448 1.00 32.82 ? 65 VAL A CB 1 ATOM 248 C CG1 . VAL A 1 39 ? -15.345 -1.919 29.320 1.00 33.62 ? 65 VAL A CG1 1 ATOM 249 C CG2 . VAL A 1 39 ? -13.942 -2.358 31.345 1.00 33.32 ? 65 VAL A CG2 1 ATOM 250 N N . LEU A 1 40 ? -15.947 -4.258 33.437 1.00 27.72 ? 66 LEU A N 1 ATOM 251 C CA . LEU A 1 40 ? -15.778 -5.369 34.379 1.00 26.02 ? 66 LEU A CA 1 ATOM 252 C C . LEU A 1 40 ? -17.015 -5.614 35.260 1.00 23.84 ? 66 LEU A C 1 ATOM 253 O O . LEU A 1 40 ? -16.973 -6.474 36.138 1.00 22.77 ? 66 LEU A O 1 ATOM 254 C CB . LEU A 1 40 ? -14.545 -5.139 35.261 1.00 26.36 ? 66 LEU A CB 1 ATOM 255 C CG . LEU A 1 40 ? -13.227 -4.865 34.524 1.00 27.15 ? 66 LEU A CG 1 ATOM 256 C CD1 . LEU A 1 40 ? -12.138 -4.404 35.485 1.00 27.45 ? 66 LEU A CD1 1 ATOM 257 C CD2 . LEU A 1 40 ? -12.766 -6.091 33.755 1.00 27.08 ? 66 LEU A CD2 1 ATOM 258 N N . SER A 1 41 ? -18.112 -4.889 35.020 1.00 21.79 ? 67 SER A N 1 ATOM 259 C CA . SER A 1 41 ? -19.365 -5.132 35.753 1.00 20.58 ? 67 SER A CA 1 ATOM 260 C C . SER A 1 41 ? -19.903 -6.544 35.500 1.00 19.76 ? 67 SER A C 1 ATOM 261 O O . SER A 1 41 ? -19.559 -7.183 34.503 1.00 19.22 ? 67 SER A O 1 ATOM 262 C CB . SER A 1 41 ? -20.442 -4.104 35.380 1.00 20.39 ? 67 SER A CB 1 ATOM 263 O OG . SER A 1 41 ? -20.957 -4.332 34.075 1.00 20.23 ? 67 SER A OG 1 ATOM 264 N N . TRP A 1 42 ? -20.741 -7.028 36.410 1.00 19.19 ? 68 TRP A N 1 ATOM 265 C CA . TRP A 1 42 ? -21.379 -8.326 36.238 1.00 18.96 ? 68 TRP A CA 1 ATOM 266 C C . TRP A 1 42 ? -22.179 -8.345 34.924 1.00 18.10 ? 68 TRP A C 1 ATOM 267 O O . TRP A 1 42 ? -22.055 -9.279 34.134 1.00 17.11 ? 68 TRP A O 1 ATOM 268 C CB . TRP A 1 42 ? -22.272 -8.660 37.440 1.00 19.65 ? 68 TRP A CB 1 ATOM 269 C CG . TRP A 1 42 ? -23.018 -9.942 37.269 1.00 20.49 ? 68 TRP A CG 1 ATOM 270 C CD1 . TRP A 1 42 ? -24.367 -10.132 37.360 1.00 20.55 ? 68 TRP A CD1 1 ATOM 271 C CD2 . TRP A 1 42 ? -22.453 -11.215 36.935 1.00 21.54 ? 68 TRP A CD2 1 ATOM 272 N NE1 . TRP A 1 42 ? -24.675 -11.455 37.118 1.00 21.24 ? 68 TRP A NE1 1 ATOM 273 C CE2 . TRP A 1 42 ? -23.516 -12.137 36.855 1.00 21.63 ? 68 TRP A CE2 1 ATOM 274 C CE3 . TRP A 1 42 ? -21.146 -11.666 36.706 1.00 22.55 ? 68 TRP A CE3 1 ATOM 275 C CZ2 . TRP A 1 42 ? -23.313 -13.481 36.552 1.00 22.58 ? 68 TRP A CZ2 1 ATOM 276 C CZ3 . TRP A 1 42 ? -20.946 -13.000 36.404 1.00 23.14 ? 68 TRP A CZ3 1 ATOM 277 C CH2 . TRP A 1 42 ? -22.023 -13.893 36.331 1.00 23.06 ? 68 TRP A CH2 1 ATOM 278 N N . ASP A 1 43 ? -22.964 -7.294 34.692 1.00 17.67 ? 69 ASP A N 1 ATOM 279 C CA . ASP A 1 43 ? -23.697 -7.113 33.430 1.00 17.67 ? 69 ASP A CA 1 ATOM 280 C C . ASP A 1 43 ? -22.814 -7.404 32.214 1.00 17.55 ? 69 ASP A C 1 ATOM 281 O O . ASP A 1 43 ? -23.217 -8.129 31.306 1.00 16.75 ? 69 ASP A O 1 ATOM 282 C CB . ASP A 1 43 ? -24.235 -5.681 33.294 1.00 17.77 ? 69 ASP A CB 1 ATOM 283 C CG . ASP A 1 43 ? -25.064 -5.241 34.489 1.00 18.07 ? 69 ASP A CG 1 ATOM 284 O OD1 . ASP A 1 43 ? -24.550 -5.310 35.621 1.00 19.06 ? 69 ASP A OD1 1 ATOM 285 O OD2 . ASP A 1 43 ? -26.221 -4.815 34.301 1.00 17.75 ? 69 ASP A OD2 1 ATOM 286 N N . GLN A 1 44 ? -21.609 -6.839 32.209 1.00 17.53 ? 70 GLN A N 1 ATOM 287 C CA . GLN A 1 44 ? -20.714 -6.981 31.066 1.00 17.88 ? 70 GLN A CA 1 ATOM 288 C C . GLN A 1 44 ? -20.126 -8.380 30.965 1.00 17.40 ? 70 GLN A C 1 ATOM 289 O O . GLN A 1 44 ? -19.957 -8.904 29.863 1.00 17.08 ? 70 GLN A O 1 ATOM 290 C CB . GLN A 1 44 ? -19.584 -5.953 31.114 1.00 18.50 ? 70 GLN A CB 1 ATOM 291 C CG . GLN A 1 44 ? -18.857 -5.817 29.788 1.00 19.31 ? 70 GLN A CG 1 ATOM 292 C CD . GLN A 1 44 ? -19.767 -5.279 28.702 1.00 19.44 ? 70 GLN A CD 1 ATOM 293 O OE1 . GLN A 1 44 ? -20.257 -4.156 28.802 1.00 20.29 ? 70 GLN A OE1 1 ATOM 294 N NE2 . GLN A 1 44 ? -20.010 -6.077 27.672 1.00 19.36 ? 70 GLN A NE2 1 ATOM 295 N N . GLN A 1 45 ? -19.801 -8.977 32.109 1.00 17.00 ? 71 GLN A N 1 ATOM 296 C CA . GLN A 1 45 ? -19.325 -10.358 32.135 1.00 16.83 ? 71 GLN A CA 1 ATOM 297 C C . GLN A 1 45 ? -20.376 -11.281 31.525 1.00 16.51 ? 71 GLN A C 1 ATOM 298 O O . GLN A 1 45 ? -20.046 -12.144 30.713 1.00 16.70 ? 71 GLN A O 1 ATOM 299 C CB . GLN A 1 45 ? -18.993 -10.793 33.563 1.00 16.95 ? 71 GLN A CB 1 ATOM 300 C CG . GLN A 1 45 ? -17.779 -10.086 34.156 1.00 17.05 ? 71 GLN A CG 1 ATOM 301 C CD . GLN A 1 45 ? -17.671 -10.282 35.653 1.00 17.24 ? 71 GLN A CD 1 ATOM 302 O OE1 . GLN A 1 45 ? -17.816 -11.397 36.151 1.00 17.97 ? 71 GLN A OE1 1 ATOM 303 N NE2 . GLN A 1 45 ? -17.426 -9.201 36.381 1.00 17.18 ? 71 GLN A NE2 1 ATOM 304 N N . LEU A 1 46 ? -21.638 -11.084 31.908 1.00 16.14 ? 72 LEU A N 1 ATOM 305 C CA . LEU A 1 46 ? -22.753 -11.824 31.311 1.00 15.87 ? 72 LEU A CA 1 ATOM 306 C C . LEU A 1 46 ? -22.836 -11.567 29.816 1.00 15.17 ? 72 LEU A C 1 ATOM 307 O O . LEU A 1 46 ? -22.912 -12.501 29.031 1.00 14.74 ? 72 LEU A O 1 ATOM 308 C CB . LEU A 1 46 ? -24.095 -11.449 31.951 1.00 16.00 ? 72 LEU A CB 1 ATOM 309 C CG . LEU A 1 46 ? -24.584 -12.262 33.150 1.00 16.56 ? 72 LEU A CG 1 ATOM 310 C CD1 . LEU A 1 46 ? -25.964 -11.773 33.585 1.00 16.45 ? 72 LEU A CD1 1 ATOM 311 C CD2 . LEU A 1 46 ? -24.634 -13.751 32.834 1.00 16.52 ? 72 LEU A CD2 1 ATOM 312 N N . ASN A 1 47 ? -22.818 -10.296 29.432 1.00 14.82 ? 73 ASN A N 1 ATOM 313 C CA . ASN A 1 47 ? -22.907 -9.918 28.024 1.00 14.63 ? 73 ASN A CA 1 ATOM 314 C C . ASN A 1 47 ? -21.873 -10.643 27.172 1.00 14.12 ? 73 ASN A C 1 ATOM 315 O O . ASN A 1 47 ? -22.208 -11.212 26.133 1.00 13.93 ? 73 ASN A O 1 ATOM 316 C CB . ASN A 1 47 ? -22.743 -8.406 27.874 1.00 14.89 ? 73 ASN A CB 1 ATOM 317 C CG . ASN A 1 47 ? -23.035 -7.913 26.466 1.00 15.09 ? 73 ASN A CG 1 ATOM 318 O OD1 . ASN A 1 47 ? -22.244 -7.161 25.886 1.00 15.67 ? 73 ASN A OD1 1 ATOM 319 N ND2 . ASN A 1 47 ? -24.174 -8.314 25.917 1.00 14.93 ? 73 ASN A ND2 1 ATOM 320 N N . LEU A 1 48 ? -20.628 -10.641 27.640 1.00 13.79 ? 74 LEU A N 1 ATOM 321 C CA . LEU A 1 48 ? -19.516 -11.266 26.920 1.00 13.80 ? 74 LEU A CA 1 ATOM 322 C C . LEU A 1 48 ? -19.582 -12.792 26.911 1.00 13.61 ? 74 LEU A C 1 ATOM 323 O O . LEU A 1 48 ? -19.059 -13.419 25.993 1.00 13.68 ? 74 LEU A O 1 ATOM 324 C CB . LEU A 1 48 ? -18.166 -10.771 27.466 1.00 13.87 ? 74 LEU A CB 1 ATOM 325 C CG . LEU A 1 48 ? -17.906 -9.299 27.102 1.00 14.07 ? 74 LEU A CG 1 ATOM 326 C CD1 . LEU A 1 48 ? -16.785 -8.694 27.936 1.00 14.28 ? 74 LEU A CD1 1 ATOM 327 C CD2 . LEU A 1 48 ? -17.608 -9.146 25.618 1.00 14.00 ? 74 LEU A CD2 1 ATOM 328 N N . ALA A 1 49 ? -20.228 -13.382 27.914 1.00 13.35 ? 75 ALA A N 1 ATOM 329 C CA . ALA A 1 49 ? -20.547 -14.813 27.878 1.00 13.46 ? 75 ALA A CA 1 ATOM 330 C C . ALA A 1 49 ? -21.500 -15.117 26.717 1.00 13.38 ? 75 ALA A C 1 ATOM 331 O O . ALA A 1 49 ? -21.311 -16.088 25.981 1.00 13.12 ? 75 ALA A O 1 ATOM 332 C CB . ALA A 1 49 ? -21.160 -15.270 29.196 1.00 13.38 ? 75 ALA A CB 1 ATOM 333 N N . TYR A 1 50 ? -22.522 -14.281 26.559 1.00 13.22 ? 76 TYR A N 1 ATOM 334 C CA . TYR A 1 50 ? -23.459 -14.439 25.448 1.00 13.21 ? 76 TYR A CA 1 ATOM 335 C C . TYR A 1 50 ? -22.751 -14.251 24.095 1.00 13.00 ? 76 TYR A C 1 ATOM 336 O O . TYR A 1 50 ? -22.928 -15.053 23.190 1.00 12.93 ? 76 TYR A O 1 ATOM 337 C CB . TYR A 1 50 ? -24.656 -13.485 25.594 1.00 13.10 ? 76 TYR A CB 1 ATOM 338 C CG . TYR A 1 50 ? -25.741 -13.989 26.530 1.00 13.23 ? 76 TYR A CG 1 ATOM 339 C CD1 . TYR A 1 50 ? -25.577 -13.957 27.916 1.00 13.15 ? 76 TYR A CD1 1 ATOM 340 C CD2 . TYR A 1 50 ? -26.932 -14.500 26.028 1.00 13.22 ? 76 TYR A CD2 1 ATOM 341 C CE1 . TYR A 1 50 ? -26.568 -14.422 28.764 1.00 13.19 ? 76 TYR A CE1 1 ATOM 342 C CE2 . TYR A 1 50 ? -27.926 -14.966 26.867 1.00 13.16 ? 76 TYR A CE2 1 ATOM 343 C CZ . TYR A 1 50 ? -27.745 -14.926 28.232 1.00 13.31 ? 76 TYR A CZ 1 ATOM 344 O OH . TYR A 1 50 ? -28.753 -15.389 29.053 1.00 13.48 ? 76 TYR A OH 1 ATOM 345 N N . VAL A 1 51 ? -21.935 -13.211 23.969 1.00 13.01 ? 77 VAL A N 1 ATOM 346 C CA . VAL A 1 51 ? -21.179 -12.974 22.727 1.00 13.05 ? 77 VAL A CA 1 ATOM 347 C C . VAL A 1 51 ? -20.285 -14.174 22.371 1.00 12.94 ? 77 VAL A C 1 ATOM 348 O O . VAL A 1 51 ? -20.269 -14.635 21.230 1.00 12.79 ? 77 VAL A O 1 ATOM 349 C CB . VAL A 1 51 ? -20.309 -11.697 22.820 1.00 13.29 ? 77 VAL A CB 1 ATOM 350 C CG1 . VAL A 1 51 ? -19.452 -11.526 21.570 1.00 13.51 ? 77 VAL A CG1 1 ATOM 351 C CG2 . VAL A 1 51 ? -21.182 -10.464 23.011 1.00 13.35 ? 77 VAL A CG2 1 ATOM 352 N N . GLY A 1 52 ? -19.545 -14.670 23.353 1.00 12.81 ? 78 GLY A N 1 ATOM 353 C CA . GLY A 1 52 ? -18.654 -15.810 23.149 1.00 12.87 ? 78 GLY A CA 1 ATOM 354 C C . GLY A 1 52 ? -19.360 -17.138 22.912 1.00 12.75 ? 78 GLY A C 1 ATOM 355 O O . GLY A 1 52 ? -18.798 -18.030 22.291 1.00 12.53 ? 78 GLY A O 1 ATOM 356 N N . ALA A 1 53 ? -20.600 -17.260 23.382 1.00 12.78 ? 79 ALA A N 1 ATOM 357 C CA . ALA A 1 53 ? -21.327 -18.524 23.309 1.00 12.91 ? 79 ALA A CA 1 ATOM 358 C C . ALA A 1 53 ? -21.875 -18.848 21.912 1.00 13.10 ? 79 ALA A C 1 ATOM 359 O O . ALA A 1 53 ? -22.445 -19.921 21.704 1.00 12.76 ? 79 ALA A O 1 ATOM 360 C CB . ALA A 1 53 ? -22.450 -18.542 24.338 1.00 12.97 ? 79 ALA A CB 1 ATOM 361 N N . VAL A 1 54 ? -21.710 -17.933 20.954 1.00 13.36 ? 80 VAL A N 1 ATOM 362 C CA . VAL A 1 54 ? -22.086 -18.221 19.571 1.00 13.28 ? 80 VAL A CA 1 ATOM 363 C C . VAL A 1 54 ? -21.242 -19.407 19.118 1.00 13.69 ? 80 VAL A C 1 ATOM 364 O O . VAL A 1 54 ? -20.016 -19.379 19.260 1.00 13.64 ? 80 VAL A O 1 ATOM 365 C CB . VAL A 1 54 ? -21.836 -17.026 18.636 1.00 13.19 ? 80 VAL A CB 1 ATOM 366 C CG1 . VAL A 1 54 ? -22.136 -17.400 17.191 1.00 13.05 ? 80 VAL A CG1 1 ATOM 367 C CG2 . VAL A 1 54 ? -22.680 -15.835 19.059 1.00 13.10 ? 80 VAL A CG2 1 ATOM 368 N N . PRO A 1 55 ? -21.890 -20.461 18.586 1.00 13.84 ? 81 PRO A N 1 ATOM 369 C CA . PRO A 1 55 ? -21.128 -21.669 18.289 1.00 13.98 ? 81 PRO A CA 1 ATOM 370 C C . PRO A 1 55 ? -20.141 -21.497 17.137 1.00 14.40 ? 81 PRO A C 1 ATOM 371 O O . PRO A 1 55 ? -20.305 -20.596 16.297 1.00 13.84 ? 81 PRO A O 1 ATOM 372 C CB . PRO A 1 55 ? -22.210 -22.695 17.937 1.00 14.02 ? 81 PRO A CB 1 ATOM 373 C CG . PRO A 1 55 ? -23.380 -21.892 17.487 1.00 13.96 ? 81 PRO A CG 1 ATOM 374 C CD . PRO A 1 55 ? -23.320 -20.602 18.248 1.00 13.86 ? 81 PRO A CD 1 ATOM 375 N N . HIS A 1 56 ? -19.118 -22.355 17.135 1.00 14.76 ? 82 HIS A N 1 ATOM 376 C CA . HIS A 1 56 ? -18.126 -22.436 16.063 1.00 15.49 ? 82 HIS A CA 1 ATOM 377 C C . HIS A 1 56 ? -17.397 -21.112 15.825 1.00 15.89 ? 82 HIS A C 1 ATOM 378 O O . HIS A 1 56 ? -17.132 -20.734 14.688 1.00 15.49 ? 82 HIS A O 1 ATOM 379 C CB . HIS A 1 56 ? -18.794 -22.951 14.781 1.00 15.76 ? 82 HIS A CB 1 ATOM 380 C CG . HIS A 1 56 ? -19.649 -24.157 15.011 1.00 16.13 ? 82 HIS A CG 1 ATOM 381 N ND1 . HIS A 1 56 ? -21.008 -24.164 14.783 1.00 16.36 ? 82 HIS A ND1 1 ATOM 382 C CD2 . HIS A 1 56 ? -19.345 -25.379 15.506 1.00 16.45 ? 82 HIS A CD2 1 ATOM 383 C CE1 . HIS A 1 56 ? -21.501 -25.347 15.098 1.00 16.36 ? 82 HIS A CE1 1 ATOM 384 N NE2 . HIS A 1 56 ? -20.512 -26.103 15.539 1.00 16.68 ? 82 HIS A NE2 1 ATOM 385 N N . ARG A 1 57 ? -17.067 -20.430 16.920 1.00 16.83 ? 83 ARG A N 1 ATOM 386 C CA . ARG A 1 57 ? -16.383 -19.134 16.881 1.00 17.73 ? 83 ARG A CA 1 ATOM 387 C C . ARG A 1 57 ? -17.066 -18.142 15.948 1.00 16.71 ? 83 ARG A C 1 ATOM 388 O O . ARG A 1 57 ? -16.395 -17.377 15.254 1.00 16.47 ? 83 ARG A O 1 ATOM 389 C CB . ARG A 1 57 ? -14.914 -19.307 16.464 1.00 19.14 ? 83 ARG A CB 1 ATOM 390 C CG . ARG A 1 57 ? -14.141 -20.316 17.296 1.00 20.71 ? 83 ARG A CG 1 ATOM 391 C CD . ARG A 1 57 ? -12.634 -20.174 17.118 1.00 22.50 ? 83 ARG A CD 1 ATOM 392 N NE . ARG A 1 57 ? -11.995 -19.423 18.208 1.00 24.70 ? 83 ARG A NE 1 ATOM 393 C CZ . ARG A 1 57 ? -11.771 -18.104 18.233 1.00 26.15 ? 83 ARG A CZ 1 ATOM 394 N NH1 . ARG A 1 57 ? -12.138 -17.313 17.230 1.00 27.01 ? 83 ARG A NH1 1 ATOM 395 N NH2 . ARG A 1 57 ? -11.172 -17.564 19.288 1.00 27.02 ? 83 ARG A NH2 1 ATOM 396 N N . GLY A 1 58 ? -18.399 -18.157 15.942 1.00 15.80 ? 84 GLY A N 1 ATOM 397 C CA . GLY A 1 58 ? -19.188 -17.272 15.090 1.00 15.06 ? 84 GLY A CA 1 ATOM 398 C C . GLY A 1 58 ? -18.966 -15.791 15.349 1.00 14.77 ? 84 GLY A C 1 ATOM 399 O O . GLY A 1 58 ? -19.282 -14.967 14.497 1.00 14.49 ? 84 GLY A O 1 ATOM 400 N N . ILE A 1 59 ? -18.465 -15.455 16.537 1.00 14.64 ? 85 ILE A N 1 ATOM 401 C CA . ILE A 1 59 ? -17.962 -14.112 16.838 1.00 14.82 ? 85 ILE A CA 1 ATOM 402 C C . ILE A 1 59 ? -16.561 -14.251 17.455 1.00 15.11 ? 85 ILE A C 1 ATOM 403 O O . ILE A 1 59 ? -16.381 -14.915 18.473 1.00 14.60 ? 85 ILE A O 1 ATOM 404 C CB . ILE A 1 59 ? -18.890 -13.329 17.792 1.00 14.58 ? 85 ILE A CB 1 ATOM 405 C CG1 . ILE A 1 59 ? -20.245 -13.066 17.126 1.00 14.46 ? 85 ILE A CG1 1 ATOM 406 C CG2 . ILE A 1 59 ? -18.244 -12.006 18.187 1.00 14.74 ? 85 ILE A CG2 1 ATOM 407 C CD1 . ILE A 1 59 ? -21.279 -12.436 18.033 1.00 14.29 ? 85 ILE A CD1 1 ATOM 408 N N . LYS A 1 60 ? -15.587 -13.607 16.822 1.00 15.62 ? 86 LYS A N 1 ATOM 409 C CA . LYS A 1 60 ? -14.178 -13.746 17.166 1.00 16.29 ? 86 LYS A CA 1 ATOM 410 C C . LYS A 1 60 ? -13.635 -12.499 17.866 1.00 15.73 ? 86 LYS A C 1 ATOM 411 O O . LYS A 1 60 ? -12.890 -12.602 18.841 1.00 16.21 ? 86 LYS A O 1 ATOM 412 C CB . LYS A 1 60 ? -13.390 -14.022 15.882 1.00 17.37 ? 86 LYS A CB 1 ATOM 413 C CG . LYS A 1 60 ? -11.880 -13.888 15.993 1.00 18.59 ? 86 LYS A CG 1 ATOM 414 C CD . LYS A 1 60 ? -11.207 -14.354 14.710 1.00 19.42 ? 86 LYS A CD 1 ATOM 415 C CE . LYS A 1 60 ? -9.692 -14.226 14.798 1.00 20.02 ? 86 LYS A CE 1 ATOM 416 N NZ . LYS A 1 60 ? -9.030 -14.885 13.637 1.00 20.54 ? 86 LYS A NZ 1 ATOM 417 N N . GLN A 1 61 ? -14.015 -11.330 17.364 1.00 14.95 ? 87 GLN A N 1 ATOM 418 C CA . GLN A 1 61 ? -13.446 -10.054 17.800 1.00 14.51 ? 87 GLN A CA 1 ATOM 419 C C . GLN A 1 61 ? -14.492 -9.161 18.470 1.00 14.03 ? 87 GLN A C 1 ATOM 420 O O . GLN A 1 61 ? -15.650 -9.116 18.047 1.00 13.56 ? 87 GLN A O 1 ATOM 421 C CB . GLN A 1 61 ? -12.829 -9.334 16.583 1.00 14.35 ? 87 GLN A CB 1 ATOM 422 C CG . GLN A 1 61 ? -12.695 -7.827 16.729 1.00 14.37 ? 87 GLN A CG 1 ATOM 423 C CD . GLN A 1 61 ? -11.952 -7.184 15.571 1.00 14.00 ? 87 GLN A CD 1 ATOM 424 O OE1 . GLN A 1 61 ? -10.736 -7.338 15.442 1.00 13.87 ? 87 GLN A OE1 1 ATOM 425 N NE2 . GLN A 1 61 ? -12.672 -6.435 14.741 1.00 13.64 ? 87 GLN A NE2 1 ATOM 426 N N . VAL A 1 62 ? -14.067 -8.454 19.514 1.00 13.86 ? 88 VAL A N 1 ATOM 427 C CA . VAL A 1 62 ? -14.878 -7.413 20.137 1.00 13.85 ? 88 VAL A CA 1 ATOM 428 C C . VAL A 1 62 ? -14.118 -6.086 20.100 1.00 13.85 ? 88 VAL A C 1 ATOM 429 O O . VAL A 1 62 ? -13.201 -5.849 20.886 1.00 13.67 ? 88 VAL A O 1 ATOM 430 C CB . VAL A 1 62 ? -15.262 -7.767 21.588 1.00 13.87 ? 88 VAL A CB 1 ATOM 431 C CG1 . VAL A 1 62 ? -16.203 -6.716 22.160 1.00 13.91 ? 88 VAL A CG1 1 ATOM 432 C CG2 . VAL A 1 62 ? -15.910 -9.140 21.649 1.00 13.90 ? 88 VAL A CG2 1 ATOM 433 N N . ARG A 1 63 ? -14.506 -5.224 19.171 1.00 14.10 ? 89 ARG A N 1 ATOM 434 C CA . ARG A 1 63 ? -13.878 -3.927 18.999 1.00 14.15 ? 89 ARG A CA 1 ATOM 435 C C . ARG A 1 63 ? -14.323 -2.994 20.118 1.00 14.20 ? 89 ARG A C 1 ATOM 436 O O . ARG A 1 63 ? -15.487 -2.624 20.189 1.00 14.43 ? 89 ARG A O 1 ATOM 437 C CB . ARG A 1 63 ? -14.254 -3.357 17.635 1.00 14.19 ? 89 ARG A CB 1 ATOM 438 C CG . ARG A 1 63 ? -13.601 -2.025 17.302 1.00 14.31 ? 89 ARG A CG 1 ATOM 439 C CD . ARG A 1 63 ? -13.730 -1.728 15.816 1.00 14.35 ? 89 ARG A CD 1 ATOM 440 N NE . ARG A 1 63 ? -13.259 -0.393 15.485 1.00 14.52 ? 89 ARG A NE 1 ATOM 441 C CZ . ARG A 1 63 ? -13.984 0.721 15.582 1.00 14.86 ? 89 ARG A CZ 1 ATOM 442 N NH1 . ARG A 1 63 ? -15.242 0.696 16.014 1.00 15.05 ? 89 ARG A NH1 1 ATOM 443 N NH2 . ARG A 1 63 ? -13.433 1.882 15.251 1.00 15.02 ? 89 ARG A NH2 1 ATOM 444 N N . THR A 1 64 ? -13.388 -2.605 20.979 1.00 14.22 ? 90 THR A N 1 ATOM 445 C CA . THR A 1 64 ? -13.724 -1.918 22.218 1.00 14.34 ? 90 THR A CA 1 ATOM 446 C C . THR A 1 64 ? -13.039 -0.556 22.323 1.00 14.67 ? 90 THR A C 1 ATOM 447 O O . THR A 1 64 ? -11.812 -0.468 22.300 1.00 14.45 ? 90 THR A O 1 ATOM 448 C CB . THR A 1 64 ? -13.321 -2.775 23.433 1.00 14.30 ? 90 THR A CB 1 ATOM 449 O OG1 . THR A 1 64 ? -13.702 -4.142 23.213 1.00 14.19 ? 90 THR A OG1 1 ATOM 450 C CG2 . THR A 1 64 ? -13.983 -2.258 24.700 1.00 14.22 ? 90 THR A CG2 1 ATOM 451 N N . HIS A 1 65 ? -13.850 0.494 22.448 1.00 15.12 ? 91 HIS A N 1 ATOM 452 C CA . HIS A 1 65 ? -13.364 1.859 22.654 1.00 15.43 ? 91 HIS A CA 1 ATOM 453 C C . HIS A 1 65 ? -12.754 2.051 24.043 1.00 15.56 ? 91 HIS A C 1 ATOM 454 O O . HIS A 1 65 ? -13.071 1.321 24.984 1.00 15.17 ? 91 HIS A O 1 ATOM 455 C CB . HIS A 1 65 ? -14.515 2.861 22.527 1.00 15.76 ? 91 HIS A CB 1 ATOM 456 C CG . HIS A 1 65 ? -15.079 2.997 21.144 1.00 16.22 ? 91 HIS A CG 1 ATOM 457 N ND1 . HIS A 1 65 ? -14.777 2.133 20.114 1.00 16.35 ? 91 HIS A ND1 1 ATOM 458 C CD2 . HIS A 1 65 ? -15.959 3.891 20.635 1.00 16.72 ? 91 HIS A CD2 1 ATOM 459 C CE1 . HIS A 1 65 ? -15.431 2.500 19.028 1.00 16.76 ? 91 HIS A CE1 1 ATOM 460 N NE2 . HIS A 1 65 ? -16.158 3.563 19.317 1.00 16.82 ? 91 HIS A NE2 1 ATOM 461 N N . TRP A 1 66 ? -11.900 3.067 24.150 1.00 15.90 ? 92 TRP A N 1 ATOM 462 C CA . TRP A 1 66 ? -11.399 3.587 25.427 1.00 16.19 ? 92 TRP A CA 1 ATOM 463 C C . TRP A 1 66 ? -10.631 2.569 26.272 1.00 16.20 ? 92 TRP A C 1 ATOM 464 O O . TRP A 1 66 ? -10.608 2.669 27.498 1.00 16.44 ? 92 TRP A O 1 ATOM 465 C CB . TRP A 1 66 ? -12.541 4.201 26.248 1.00 16.48 ? 92 TRP A CB 1 ATOM 466 C CG . TRP A 1 66 ? -13.231 5.342 25.563 1.00 16.61 ? 92 TRP A CG 1 ATOM 467 C CD1 . TRP A 1 66 ? -14.526 5.377 25.134 1.00 16.75 ? 92 TRP A CD1 1 ATOM 468 C CD2 . TRP A 1 66 ? -12.663 6.615 25.230 1.00 16.82 ? 92 TRP A CD2 1 ATOM 469 N NE1 . TRP A 1 66 ? -14.799 6.592 24.549 1.00 16.73 ? 92 TRP A NE1 1 ATOM 470 C CE2 . TRP A 1 66 ? -13.675 7.372 24.599 1.00 16.73 ? 92 TRP A CE2 1 ATOM 471 C CE3 . TRP A 1 66 ? -11.399 7.190 25.405 1.00 17.04 ? 92 TRP A CE3 1 ATOM 472 C CZ2 . TRP A 1 66 ? -13.462 8.669 24.140 1.00 16.76 ? 92 TRP A CZ2 1 ATOM 473 C CZ3 . TRP A 1 66 ? -11.187 8.486 24.947 1.00 17.07 ? 92 TRP A CZ3 1 ATOM 474 C CH2 . TRP A 1 66 ? -12.216 9.209 24.322 1.00 17.10 ? 92 TRP A CH2 1 ATOM 475 N N . LEU A 1 67 ? -9.983 1.609 25.615 1.00 16.15 ? 93 LEU A N 1 ATOM 476 C CA . LEU A 1 67 ? -9.184 0.604 26.315 1.00 16.19 ? 93 LEU A CA 1 ATOM 477 C C . LEU A 1 67 ? -8.024 1.204 27.101 1.00 16.43 ? 93 LEU A C 1 ATOM 478 O O . LEU A 1 67 ? -7.585 0.624 28.090 1.00 16.25 ? 93 LEU A O 1 ATOM 479 C CB . LEU A 1 67 ? -8.625 -0.425 25.337 1.00 16.01 ? 93 LEU A CB 1 ATOM 480 C CG . LEU A 1 67 ? -9.623 -1.418 24.755 1.00 16.02 ? 93 LEU A CG 1 ATOM 481 C CD1 . LEU A 1 67 ? -8.987 -2.143 23.584 1.00 16.00 ? 93 LEU A CD1 1 ATOM 482 C CD2 . LEU A 1 67 ? -10.093 -2.409 25.811 1.00 16.03 ? 93 LEU A CD2 1 ATOM 483 N N . LEU A 1 68 ? -7.511 2.344 26.659 1.00 17.01 ? 94 LEU A N 1 ATOM 484 C CA . LEU A 1 68 ? -6.395 2.974 27.357 1.00 17.84 ? 94 LEU A CA 1 ATOM 485 C C . LEU A 1 68 ? -6.838 3.993 28.418 1.00 18.46 ? 94 LEU A C 1 ATOM 486 O O . LEU A 1 68 ? -6.000 4.698 28.979 1.00 17.85 ? 94 LEU A O 1 ATOM 487 C CB . LEU A 1 68 ? -5.405 3.578 26.361 1.00 18.02 ? 94 LEU A CB 1 ATOM 488 C CG . LEU A 1 68 ? -4.875 2.577 25.326 1.00 18.38 ? 94 LEU A CG 1 ATOM 489 C CD1 . LEU A 1 68 ? -3.790 3.223 24.477 1.00 18.39 ? 94 LEU A CD1 1 ATOM 490 C CD2 . LEU A 1 68 ? -4.355 1.300 25.976 1.00 18.43 ? 94 LEU A CD2 1 ATOM 491 N N . GLU A 1 69 ? -8.145 4.057 28.695 1.00 19.16 ? 95 GLU A N 1 ATOM 492 C CA . GLU A 1 69 ? -8.641 4.640 29.955 1.00 20.17 ? 95 GLU A CA 1 ATOM 493 C C . GLU A 1 69 ? -8.661 3.585 31.075 1.00 20.65 ? 95 GLU A C 1 ATOM 494 O O . GLU A 1 69 ? -8.827 3.922 32.244 1.00 21.17 ? 95 GLU A O 1 ATOM 495 C CB . GLU A 1 69 ? -10.039 5.248 29.782 1.00 20.30 ? 95 GLU A CB 1 ATOM 496 C CG . GLU A 1 69 ? -10.108 6.422 28.810 1.00 20.62 ? 95 GLU A CG 1 ATOM 497 C CD . GLU A 1 69 ? -9.294 7.628 29.253 1.00 21.23 ? 95 GLU A CD 1 ATOM 498 O OE1 . GLU A 1 69 ? -9.057 7.787 30.466 1.00 22.41 ? 95 GLU A OE1 1 ATOM 499 O OE2 . GLU A 1 69 ? -8.887 8.430 28.387 1.00 21.55 ? 95 GLU A OE2 1 ATOM 500 N N . LEU A 1 70 ? -8.490 2.312 30.717 1.00 21.36 ? 96 LEU A N 1 ATOM 501 C CA . LEU A 1 70 ? -8.359 1.236 31.702 1.00 21.87 ? 96 LEU A CA 1 ATOM 502 C C . LEU A 1 70 ? -6.917 1.105 32.210 1.00 22.64 ? 96 LEU A C 1 ATOM 503 O O . LEU A 1 70 ? -6.603 0.177 32.957 1.00 23.18 ? 96 LEU A O 1 ATOM 504 C CB . LEU A 1 70 ? -8.828 -0.103 31.110 1.00 21.90 ? 96 LEU A CB 1 ATOM 505 C CG . LEU A 1 70 ? -10.233 -0.159 30.492 1.00 21.80 ? 96 LEU A CG 1 ATOM 506 C CD1 . LEU A 1 70 ? -10.502 -1.528 29.880 1.00 21.72 ? 96 LEU A CD1 1 ATOM 507 C CD2 . LEU A 1 70 ? -11.308 0.177 31.510 1.00 21.62 ? 96 LEU A CD2 1 ATOM 508 N N . VAL A 1 71 ? -6.046 2.021 31.783 1.00 23.28 ? 97 VAL A N 1 ATOM 509 C CA . VAL A 1 71 ? -4.670 2.115 32.268 1.00 23.63 ? 97 VAL A CA 1 ATOM 510 C C . VAL A 1 71 ? -4.531 3.411 33.062 1.00 24.55 ? 97 VAL A C 1 ATOM 511 O O . VAL A 1 71 ? -5.080 4.442 32.672 1.00 24.55 ? 97 VAL A O 1 ATOM 512 C CB . VAL A 1 71 ? -3.666 2.128 31.090 1.00 23.75 ? 97 VAL A CB 1 ATOM 513 C CG1 . VAL A 1 71 ? -2.254 2.437 31.566 1.00 23.76 ? 97 VAL A CG1 1 ATOM 514 C CG2 . VAL A 1 71 ? -3.686 0.797 30.348 1.00 23.70 ? 97 VAL A CG2 1 ATOM 515 N N . THR A 1 72 ? -3.806 3.350 34.176 1.00 25.65 ? 98 THR A N 1 ATOM 516 C CA . THR A 1 72 ? -3.487 4.535 34.977 1.00 27.24 ? 98 THR A CA 1 ATOM 517 C C . THR A 1 72 ? -1.975 4.641 35.157 1.00 28.89 ? 98 THR A C 1 ATOM 518 O O . THR A 1 72 ? -1.263 3.634 35.092 1.00 28.93 ? 98 THR A O 1 ATOM 519 C CB . THR A 1 72 ? -4.150 4.490 36.371 1.00 27.08 ? 98 THR A CB 1 ATOM 520 O OG1 . THR A 1 72 ? -3.552 3.451 37.157 1.00 27.06 ? 98 THR A OG1 1 ATOM 521 C CG2 . THR A 1 72 ? -5.657 4.248 36.263 1.00 26.75 ? 98 THR A CG2 1 ATOM 522 N N . THR A 1 73 ? -1.493 5.860 35.387 1.00 31.31 ? 99 THR A N 1 ATOM 523 C CA . THR A 1 73 ? -0.062 6.113 35.565 1.00 34.22 ? 99 THR A CA 1 ATOM 524 C C . THR A 1 73 ? 0.330 6.036 37.043 1.00 35.02 ? 99 THR A C 1 ATOM 525 O O . THR A 1 73 ? -0.202 6.771 37.873 1.00 35.67 ? 99 THR A O 1 ATOM 526 C CB . THR A 1 73 ? 0.336 7.490 35.004 1.00 35.75 ? 99 THR A CB 1 ATOM 527 O OG1 . THR A 1 73 ? -0.036 7.574 33.621 1.00 36.43 ? 99 THR A OG1 1 ATOM 528 C CG2 . THR A 1 73 ? 1.838 7.712 35.125 1.00 36.92 ? 99 THR A CG2 1 ATOM 529 N N . LEU A 1 81 ? 8.079 6.943 35.408 1.00 35.79 ? 107 LEU A N 1 ATOM 530 C CA . LEU A 1 81 ? 6.819 6.866 34.671 1.00 35.91 ? 107 LEU A CA 1 ATOM 531 C C . LEU A 1 81 ? 6.422 5.414 34.398 1.00 35.15 ? 107 LEU A C 1 ATOM 532 O O . LEU A 1 81 ? 6.960 4.772 33.491 1.00 35.20 ? 107 LEU A O 1 ATOM 533 C CB . LEU A 1 81 ? 6.930 7.639 33.353 1.00 36.84 ? 107 LEU A CB 1 ATOM 534 C CG . LEU A 1 81 ? 5.692 7.702 32.455 1.00 36.88 ? 107 LEU A CG 1 ATOM 535 C CD1 . LEU A 1 81 ? 4.548 8.403 33.167 1.00 37.22 ? 107 LEU A CD1 1 ATOM 536 C CD2 . LEU A 1 81 ? 6.026 8.418 31.156 1.00 37.30 ? 107 LEU A CD2 1 ATOM 537 N N . SER A 1 82 ? 5.475 4.906 35.185 1.00 33.48 ? 108 SER A N 1 ATOM 538 C CA . SER A 1 82 ? 5.036 3.517 35.079 1.00 31.88 ? 108 SER A CA 1 ATOM 539 C C . SER A 1 82 ? 3.511 3.422 35.070 1.00 30.51 ? 108 SER A C 1 ATOM 540 O O . SER A 1 82 ? 2.817 4.275 35.629 1.00 29.51 ? 108 SER A O 1 ATOM 541 C CB . SER A 1 82 ? 5.600 2.700 36.239 1.00 31.30 ? 108 SER A CB 1 ATOM 542 O OG . SER A 1 82 ? 5.078 3.168 37.465 1.00 31.86 ? 108 SER A OG 1 ATOM 543 N N . TYR A 1 83 ? 3.001 2.365 34.445 1.00 29.19 ? 109 TYR A N 1 ATOM 544 C CA . TYR A 1 83 ? 1.567 2.203 34.252 1.00 28.39 ? 109 TYR A CA 1 ATOM 545 C C . TYR A 1 83 ? 1.018 1.043 35.068 1.00 28.48 ? 109 TYR A C 1 ATOM 546 O O . TYR A 1 83 ? 1.667 0.007 35.210 1.00 27.77 ? 109 TYR A O 1 ATOM 547 C CB . TYR A 1 83 ? 1.260 1.996 32.768 1.00 27.58 ? 109 TYR A CB 1 ATOM 548 C CG . TYR A 1 83 ? 1.741 3.130 31.898 1.00 27.25 ? 109 TYR A CG 1 ATOM 549 C CD1 . TYR A 1 83 ? 0.992 4.296 31.766 1.00 27.18 ? 109 TYR A CD1 1 ATOM 550 C CD2 . TYR A 1 83 ? 2.955 3.046 31.219 1.00 27.10 ? 109 TYR A CD2 1 ATOM 551 C CE1 . TYR A 1 83 ? 1.432 5.345 30.972 1.00 27.51 ? 109 TYR A CE1 1 ATOM 552 C CE2 . TYR A 1 83 ? 3.404 4.088 30.425 1.00 27.19 ? 109 TYR A CE2 1 ATOM 553 C CZ . TYR A 1 83 ? 2.641 5.236 30.304 1.00 27.64 ? 109 TYR A CZ 1 ATOM 554 O OH . TYR A 1 83 ? 3.089 6.279 29.515 1.00 28.09 ? 109 TYR A OH 1 ATOM 555 N N . ASN A 1 84 ? -0.178 1.245 35.613 1.00 28.89 ? 110 ASN A N 1 ATOM 556 C CA . ASN A 1 84 ? -0.941 0.184 36.253 1.00 29.89 ? 110 ASN A CA 1 ATOM 557 C C . ASN A 1 84 ? -1.927 -0.377 35.224 1.00 27.93 ? 110 ASN A C 1 ATOM 558 O O . ASN A 1 84 ? -2.858 0.313 34.810 1.00 26.66 ? 110 ASN A O 1 ATOM 559 C CB . ASN A 1 84 ? -1.671 0.731 37.483 1.00 31.82 ? 110 ASN A CB 1 ATOM 560 C CG . ASN A 1 84 ? -2.533 -0.307 38.176 1.00 34.95 ? 110 ASN A CG 1 ATOM 561 O OD1 . ASN A 1 84 ? -2.783 -1.389 37.643 1.00 34.62 ? 110 ASN A OD1 1 ATOM 562 N ND2 . ASN A 1 84 ? -3.007 0.032 39.388 1.00 38.87 ? 110 ASN A ND2 1 ATOM 563 N N . PHE A 1 85 ? -1.709 -1.628 34.824 1.00 26.42 ? 111 PHE A N 1 ATOM 564 C CA . PHE A 1 85 ? -2.499 -2.276 33.778 1.00 25.37 ? 111 PHE A CA 1 ATOM 565 C C . PHE A 1 85 ? -3.635 -3.138 34.319 1.00 24.38 ? 111 PHE A C 1 ATOM 566 O O . PHE A 1 85 ? -4.275 -3.852 33.550 1.00 24.54 ? 111 PHE A O 1 ATOM 567 C CB . PHE A 1 85 ? -1.590 -3.155 32.908 1.00 25.31 ? 111 PHE A CB 1 ATOM 568 C CG . PHE A 1 85 ? -0.592 -2.381 32.094 1.00 25.60 ? 111 PHE A CG 1 ATOM 569 C CD1 . PHE A 1 85 ? -0.989 -1.703 30.953 1.00 25.32 ? 111 PHE A CD1 1 ATOM 570 C CD2 . PHE A 1 85 ? 0.749 -2.337 32.465 1.00 25.80 ? 111 PHE A CD2 1 ATOM 571 C CE1 . PHE A 1 85 ? -0.074 -0.992 30.197 1.00 25.77 ? 111 PHE A CE1 1 ATOM 572 C CE2 . PHE A 1 85 ? 1.668 -1.627 31.714 1.00 25.88 ? 111 PHE A CE2 1 ATOM 573 C CZ . PHE A 1 85 ? 1.257 -0.953 30.578 1.00 25.99 ? 111 PHE A CZ 1 ATOM 574 N N . THR A 1 86 ? -3.899 -3.069 35.622 1.00 23.52 ? 112 THR A N 1 ATOM 575 C CA . THR A 1 86 ? -4.806 -4.024 36.278 1.00 23.49 ? 112 THR A CA 1 ATOM 576 C C . THR A 1 86 ? -6.165 -4.142 35.588 1.00 22.60 ? 112 THR A C 1 ATOM 577 O O . THR A 1 86 ? -6.618 -5.244 35.292 1.00 22.35 ? 112 THR A O 1 ATOM 578 C CB . THR A 1 86 ? -5.032 -3.664 37.760 1.00 23.63 ? 112 THR A CB 1 ATOM 579 O OG1 . THR A 1 86 ? -3.782 -3.707 38.453 1.00 23.79 ? 112 THR A OG1 1 ATOM 580 C CG2 . THR A 1 86 ? -6.007 -4.635 38.423 1.00 23.68 ? 112 THR A CG2 1 ATOM 581 N N . HIS A 1 87 ? -6.811 -3.009 35.340 1.00 22.18 ? 113 HIS A N 1 ATOM 582 C CA . HIS A 1 87 ? -8.155 -3.015 34.758 1.00 21.65 ? 113 HIS A CA 1 ATOM 583 C C . HIS A 1 87 ? -8.157 -3.504 33.309 1.00 20.76 ? 113 HIS A C 1 ATOM 584 O O . HIS A 1 87 ? -9.088 -4.198 32.888 1.00 19.92 ? 113 HIS A O 1 ATOM 585 C CB . HIS A 1 87 ? -8.804 -1.635 34.877 1.00 22.44 ? 113 HIS A CB 1 ATOM 586 C CG . HIS A 1 87 ? -9.247 -1.297 36.268 1.00 23.54 ? 113 HIS A CG 1 ATOM 587 N ND1 . HIS A 1 87 ? -9.184 -0.019 36.781 1.00 24.00 ? 113 HIS A ND1 1 ATOM 588 C CD2 . HIS A 1 87 ? -9.757 -2.074 37.254 1.00 23.92 ? 113 HIS A CD2 1 ATOM 589 C CE1 . HIS A 1 87 ? -9.641 -0.022 38.021 1.00 24.37 ? 113 HIS A CE1 1 ATOM 590 N NE2 . HIS A 1 87 ? -9.997 -1.256 38.331 1.00 24.61 ? 113 HIS A NE2 1 ATOM 591 N N . LEU A 1 88 ? -7.110 -3.158 32.558 1.00 19.84 ? 114 LEU A N 1 ATOM 592 C CA . LEU A 1 88 ? -6.947 -3.660 31.195 1.00 19.24 ? 114 LEU A CA 1 ATOM 593 C C . LEU A 1 88 ? -6.721 -5.171 31.208 1.00 19.03 ? 114 LEU A C 1 ATOM 594 O O . LEU A 1 88 ? -7.313 -5.889 30.398 1.00 18.88 ? 114 LEU A O 1 ATOM 595 C CB . LEU A 1 88 ? -5.795 -2.953 30.477 1.00 19.01 ? 114 LEU A CB 1 ATOM 596 C CG . LEU A 1 88 ? -5.661 -3.223 28.978 1.00 18.87 ? 114 LEU A CG 1 ATOM 597 C CD1 . LEU A 1 88 ? -6.930 -2.832 28.232 1.00 18.77 ? 114 LEU A CD1 1 ATOM 598 C CD2 . LEU A 1 88 ? -4.460 -2.479 28.417 1.00 18.89 ? 114 LEU A CD2 1 ATOM 599 N N . ASP A 1 89 ? -5.871 -5.638 32.127 1.00 18.72 ? 115 ASP A N 1 ATOM 600 C CA . ASP A 1 89 ? -5.677 -7.070 32.372 1.00 18.57 ? 115 ASP A CA 1 ATOM 601 C C . ASP A 1 89 ? -7.033 -7.731 32.600 1.00 18.24 ? 115 ASP A C 1 ATOM 602 O O . ASP A 1 89 ? -7.363 -8.722 31.960 1.00 18.60 ? 115 ASP A O 1 ATOM 603 C CB . ASP A 1 89 ? -4.809 -7.326 33.618 1.00 18.75 ? 115 ASP A CB 1 ATOM 604 C CG . ASP A 1 89 ? -3.348 -6.915 33.444 1.00 18.89 ? 115 ASP A CG 1 ATOM 605 O OD1 . ASP A 1 89 ? -2.929 -6.476 32.358 1.00 18.78 ? 115 ASP A OD1 1 ATOM 606 O OD2 . ASP A 1 89 ? -2.597 -7.044 34.429 1.00 19.34 ? 115 ASP A OD2 1 ATOM 607 N N . GLY A 1 90 ? -7.814 -7.171 33.516 1.00 17.83 ? 116 GLY A N 1 ATOM 608 C CA . GLY A 1 90 ? -9.131 -7.711 33.839 1.00 17.52 ? 116 GLY A CA 1 ATOM 609 C C . GLY A 1 90 ? -10.007 -7.893 32.613 1.00 17.38 ? 116 GLY A C 1 ATOM 610 O O . GLY A 1 90 ? -10.585 -8.967 32.400 1.00 17.70 ? 116 GLY A O 1 ATOM 611 N N . TYR A 1 91 ? -10.091 -6.850 31.793 1.00 16.84 ? 117 TYR A N 1 ATOM 612 C CA . TYR A 1 91 ? -10.946 -6.881 30.616 1.00 16.42 ? 117 TYR A CA 1 ATOM 613 C C . TYR A 1 91 ? -10.449 -7.869 29.567 1.00 16.29 ? 117 TYR A C 1 ATOM 614 O O . TYR A 1 91 ? -11.245 -8.607 28.985 1.00 16.37 ? 117 TYR A O 1 ATOM 615 C CB . TYR A 1 91 ? -11.087 -5.495 29.993 1.00 16.34 ? 117 TYR A CB 1 ATOM 616 C CG . TYR A 1 91 ? -11.973 -5.509 28.770 1.00 16.48 ? 117 TYR A CG 1 ATOM 617 C CD1 . TYR A 1 91 ? -13.333 -5.791 28.876 1.00 16.44 ? 117 TYR A CD1 1 ATOM 618 C CD2 . TYR A 1 91 ? -11.448 -5.281 27.506 1.00 16.42 ? 117 TYR A CD2 1 ATOM 619 C CE1 . TYR A 1 91 ? -14.148 -5.823 27.756 1.00 16.47 ? 117 TYR A CE1 1 ATOM 620 C CE2 . TYR A 1 91 ? -12.254 -5.311 26.383 1.00 16.54 ? 117 TYR A CE2 1 ATOM 621 C CZ . TYR A 1 91 ? -13.600 -5.580 26.513 1.00 16.47 ? 117 TYR A CZ 1 ATOM 622 O OH . TYR A 1 91 ? -14.391 -5.607 25.394 1.00 16.71 ? 117 TYR A OH 1 ATOM 623 N N . LEU A 1 92 ? -9.142 -7.882 29.315 1.00 15.96 ? 118 LEU A N 1 ATOM 624 C CA . LEU A 1 92 ? -8.594 -8.758 28.282 1.00 15.70 ? 118 LEU A CA 1 ATOM 625 C C . LEU A 1 92 ? -8.649 -10.228 28.703 1.00 15.30 ? 118 LEU A C 1 ATOM 626 O O . LEU A 1 92 ? -8.860 -11.101 27.862 1.00 15.17 ? 118 LEU A O 1 ATOM 627 C CB . LEU A 1 92 ? -7.172 -8.338 27.899 1.00 15.81 ? 118 LEU A CB 1 ATOM 628 C CG . LEU A 1 92 ? -7.055 -6.949 27.251 1.00 16.09 ? 118 LEU A CG 1 ATOM 629 C CD1 . LEU A 1 92 ? -5.596 -6.592 27.008 1.00 16.05 ? 118 LEU A CD1 1 ATOM 630 C CD2 . LEU A 1 92 ? -7.858 -6.849 25.961 1.00 16.03 ? 118 LEU A CD2 1 ATOM 631 N N . ASP A 1 93 ? -8.475 -10.497 29.997 1.00 14.82 ? 119 ASP A N 1 ATOM 632 C CA . ASP A 1 93 ? -8.672 -11.847 30.537 1.00 14.71 ? 119 ASP A CA 1 ATOM 633 C C . ASP A 1 93 ? -10.135 -12.275 30.374 1.00 14.39 ? 119 ASP A C 1 ATOM 634 O O . ASP A 1 93 ? -10.417 -13.421 30.030 1.00 14.18 ? 119 ASP A O 1 ATOM 635 C CB . ASP A 1 93 ? -8.267 -11.918 32.018 1.00 14.98 ? 119 ASP A CB 1 ATOM 636 C CG . ASP A 1 93 ? -6.751 -11.821 32.235 1.00 15.43 ? 119 ASP A CG 1 ATOM 637 O OD1 . ASP A 1 93 ? -5.967 -11.937 31.267 1.00 15.94 ? 119 ASP A OD1 1 ATOM 638 O OD2 . ASP A 1 93 ? -6.335 -11.638 33.399 1.00 15.68 ? 119 ASP A OD2 1 ATOM 639 N N . LEU A 1 94 ? -11.058 -11.346 30.607 1.00 14.20 ? 120 LEU A N 1 ATOM 640 C CA . LEU A 1 94 ? -12.483 -11.627 30.451 1.00 14.23 ? 120 LEU A CA 1 ATOM 641 C C . LEU A 1 94 ? -12.812 -12.014 29.006 1.00 14.11 ? 120 LEU A C 1 ATOM 642 O O . LEU A 1 94 ? -13.572 -12.962 28.768 1.00 13.62 ? 120 LEU A O 1 ATOM 643 C CB . LEU A 1 94 ? -13.325 -10.430 30.909 1.00 14.32 ? 120 LEU A CB 1 ATOM 644 C CG . LEU A 1 94 ? -14.845 -10.521 30.756 1.00 14.53 ? 120 LEU A CG 1 ATOM 645 C CD1 . LEU A 1 94 ? -15.398 -11.773 31.421 1.00 14.59 ? 120 LEU A CD1 1 ATOM 646 C CD2 . LEU A 1 94 ? -15.492 -9.269 31.334 1.00 14.56 ? 120 LEU A CD2 1 ATOM 647 N N . LEU A 1 95 ? -12.231 -11.297 28.046 1.00 14.03 ? 121 LEU A N 1 ATOM 648 C CA . LEU A 1 95 ? -12.379 -11.669 26.641 1.00 14.10 ? 121 LEU A CA 1 ATOM 649 C C . LEU A 1 95 ? -11.767 -13.049 26.369 1.00 14.39 ? 121 LEU A C 1 ATOM 650 O O . LEU A 1 95 ? -12.412 -13.904 25.760 1.00 14.29 ? 121 LEU A O 1 ATOM 651 C CB . LEU A 1 95 ? -11.751 -10.621 25.721 1.00 13.95 ? 121 LEU A CB 1 ATOM 652 C CG . LEU A 1 95 ? -12.424 -9.250 25.608 1.00 13.78 ? 121 LEU A CG 1 ATOM 653 C CD1 . LEU A 1 95 ? -11.597 -8.366 24.686 1.00 13.75 ? 121 LEU A CD1 1 ATOM 654 C CD2 . LEU A 1 95 ? -13.857 -9.347 25.103 1.00 13.65 ? 121 LEU A CD2 1 ATOM 655 N N A ARG A 1 96 ? -10.532 -13.246 26.829 0.50 14.58 ? 122 ARG A N 1 ATOM 656 N N B ARG A 1 96 ? -10.533 -13.262 26.824 0.50 14.62 ? 122 ARG A N 1 ATOM 657 C CA A ARG A 1 96 ? -9.810 -14.510 26.659 0.50 14.85 ? 122 ARG A CA 1 ATOM 658 C CA B ARG A 1 96 ? -9.834 -14.535 26.611 0.50 14.91 ? 122 ARG A CA 1 ATOM 659 C C A ARG A 1 96 ? -10.608 -15.703 27.193 0.50 14.84 ? 122 ARG A C 1 ATOM 660 C C B ARG A 1 96 ? -10.603 -15.724 27.198 0.50 14.88 ? 122 ARG A C 1 ATOM 661 O O A ARG A 1 96 ? -10.691 -16.748 26.550 0.50 14.55 ? 122 ARG A O 1 ATOM 662 O O B ARG A 1 96 ? -10.661 -16.793 26.592 0.50 14.60 ? 122 ARG A O 1 ATOM 663 C CB A ARG A 1 96 ? -8.462 -14.431 27.380 0.50 15.09 ? 122 ARG A CB 1 ATOM 664 C CB B ARG A 1 96 ? -8.421 -14.471 27.201 0.50 15.20 ? 122 ARG A CB 1 ATOM 665 C CG A ARG A 1 96 ? -7.478 -15.526 27.000 0.50 15.33 ? 122 ARG A CG 1 ATOM 666 C CG B ARG A 1 96 ? -7.644 -15.782 27.141 0.50 15.46 ? 122 ARG A CG 1 ATOM 667 C CD A ARG A 1 96 ? -6.759 -15.201 25.699 0.50 15.44 ? 122 ARG A CD 1 ATOM 668 C CD B ARG A 1 96 ? -6.149 -15.525 27.279 0.50 15.65 ? 122 ARG A CD 1 ATOM 669 N NE A ARG A 1 96 ? -5.705 -16.169 25.398 0.50 15.53 ? 122 ARG A NE 1 ATOM 670 N NE B ARG A 1 96 ? -5.428 -16.650 27.873 0.50 15.88 ? 122 ARG A NE 1 ATOM 671 C CZ A ARG A 1 96 ? -5.789 -17.103 24.455 0.50 15.58 ? 122 ARG A CZ 1 ATOM 672 C CZ B ARG A 1 96 ? -4.469 -17.344 27.269 0.50 15.90 ? 122 ARG A CZ 1 ATOM 673 N NH1 A ARG A 1 96 ? -6.880 -17.201 23.708 0.50 15.74 ? 122 ARG A NH1 1 ATOM 674 N NH1 B ARG A 1 96 ? -4.092 -17.038 26.037 0.50 16.08 ? 122 ARG A NH1 1 ATOM 675 N NH2 A ARG A 1 96 ? -4.780 -17.939 24.258 0.50 15.55 ? 122 ARG A NH2 1 ATOM 676 N NH2 B ARG A 1 96 ? -3.884 -18.348 27.903 0.50 16.03 ? 122 ARG A NH2 1 ATOM 677 N N . GLU A 1 97 ? -11.208 -15.521 28.366 1.00 15.03 ? 123 GLU A N 1 ATOM 678 C CA . GLU A 1 97 ? -12.042 -16.545 29.012 1.00 15.53 ? 123 GLU A CA 1 ATOM 679 C C . GLU A 1 97 ? -13.236 -17.007 28.140 1.00 15.28 ? 123 GLU A C 1 ATOM 680 O O . GLU A 1 97 ? -13.688 -18.143 28.257 1.00 15.36 ? 123 GLU A O 1 ATOM 681 C CB . GLU A 1 97 ? -12.543 -15.988 30.348 1.00 16.42 ? 123 GLU A CB 1 ATOM 682 C CG . GLU A 1 97 ? -13.172 -16.994 31.296 1.00 17.45 ? 123 GLU A CG 1 ATOM 683 C CD . GLU A 1 97 ? -13.488 -16.385 32.658 1.00 18.12 ? 123 GLU A CD 1 ATOM 684 O OE1 . GLU A 1 97 ? -13.983 -17.119 33.537 1.00 18.77 ? 123 GLU A OE1 1 ATOM 685 O OE2 . GLU A 1 97 ? -13.243 -15.175 32.855 1.00 18.38 ? 123 GLU A OE2 1 ATOM 686 N N . ASN A 1 98 ? -13.721 -16.121 27.271 1.00 14.57 ? 124 ASN A N 1 ATOM 687 C CA . ASN A 1 98 ? -14.769 -16.435 26.305 1.00 14.51 ? 124 ASN A CA 1 ATOM 688 C C . ASN A 1 98 ? -14.234 -16.684 24.883 1.00 14.41 ? 124 ASN A C 1 ATOM 689 O O . ASN A 1 98 ? -14.998 -16.658 23.925 1.00 14.28 ? 124 ASN A O 1 ATOM 690 C CB . ASN A 1 98 ? -15.779 -15.286 26.275 1.00 14.48 ? 124 ASN A CB 1 ATOM 691 C CG . ASN A 1 98 ? -16.470 -15.086 27.612 1.00 14.45 ? 124 ASN A CG 1 ATOM 692 O OD1 . ASN A 1 98 ? -17.346 -15.864 27.983 1.00 14.41 ? 124 ASN A OD1 1 ATOM 693 N ND2 . ASN A 1 98 ? -16.074 -14.049 28.348 1.00 14.45 ? 124 ASN A ND2 1 ATOM 694 N N . GLN A 1 99 ? -12.928 -16.929 24.768 1.00 14.41 ? 125 GLN A N 1 ATOM 695 C CA . GLN A 1 99 ? -12.234 -17.120 23.487 1.00 14.54 ? 125 GLN A CA 1 ATOM 696 C C . GLN A 1 99 ? -12.494 -15.990 22.499 1.00 14.38 ? 125 GLN A C 1 ATOM 697 O O . GLN A 1 99 ? -12.690 -16.227 21.313 1.00 14.21 ? 125 GLN A O 1 ATOM 698 C CB . GLN A 1 99 ? -12.582 -18.481 22.853 1.00 14.79 ? 125 GLN A CB 1 ATOM 699 C CG . GLN A 1 99 ? -12.052 -19.667 23.638 1.00 14.96 ? 125 GLN A CG 1 ATOM 700 C CD . GLN A 1 99 ? -12.775 -19.847 24.956 1.00 15.14 ? 125 GLN A CD 1 ATOM 701 O OE1 . GLN A 1 99 ? -12.174 -19.784 26.028 1.00 15.11 ? 125 GLN A OE1 1 ATOM 702 N NE2 . GLN A 1 99 ? -14.082 -20.044 24.882 1.00 15.43 ? 125 GLN A NE2 1 ATOM 703 N N . LEU A 1 100 ? -12.486 -14.759 22.996 1.00 14.44 ? 126 LEU A N 1 ATOM 704 C CA . LEU A 1 100 ? -12.701 -13.589 22.157 1.00 14.40 ? 126 LEU A CA 1 ATOM 705 C C . LEU A 1 100 ? -11.424 -12.768 22.078 1.00 14.77 ? 126 LEU A C 1 ATOM 706 O O . LEU A 1 100 ? -10.641 -12.747 23.025 1.00 14.78 ? 126 LEU A O 1 ATOM 707 C CB . LEU A 1 100 ? -13.843 -12.738 22.720 1.00 14.22 ? 126 LEU A CB 1 ATOM 708 C CG . LEU A 1 100 ? -15.228 -13.396 22.685 1.00 14.08 ? 126 LEU A CG 1 ATOM 709 C CD1 . LEU A 1 100 ? -16.240 -12.610 23.510 1.00 14.02 ? 126 LEU A CD1 1 ATOM 710 C CD2 . LEU A 1 100 ? -15.710 -13.546 21.253 1.00 13.93 ? 126 LEU A CD2 1 ATOM 711 N N . LEU A 1 101 ? -11.219 -12.101 20.942 1.00 15.17 ? 127 LEU A N 1 ATOM 712 C CA . LEU A 1 101 ? -10.092 -11.192 20.763 1.00 15.27 ? 127 LEU A CA 1 ATOM 713 C C . LEU A 1 101 ? -10.537 -9.747 20.934 1.00 14.83 ? 127 LEU A C 1 ATOM 714 O O . LEU A 1 101 ? -11.677 -9.403 20.628 1.00 14.57 ? 127 LEU A O 1 ATOM 715 C CB . LEU A 1 101 ? -9.482 -11.342 19.366 1.00 15.80 ? 127 LEU A CB 1 ATOM 716 C CG . LEU A 1 101 ? -9.068 -12.746 18.918 1.00 16.35 ? 127 LEU A CG 1 ATOM 717 C CD1 . LEU A 1 101 ? -8.357 -12.681 17.578 1.00 16.52 ? 127 LEU A CD1 1 ATOM 718 C CD2 . LEU A 1 101 ? -8.163 -13.382 19.949 1.00 16.60 ? 127 LEU A CD2 1 ATOM 719 N N . PRO A 1 102 ? -9.631 -8.887 21.417 1.00 14.41 ? 128 PRO A N 1 ATOM 720 C CA . PRO A 1 102 ? -9.917 -7.464 21.409 1.00 14.31 ? 128 PRO A CA 1 ATOM 721 C C . PRO A 1 102 ? -9.693 -6.858 20.029 1.00 14.25 ? 128 PRO A C 1 ATOM 722 O O . PRO A 1 102 ? -8.691 -7.147 19.389 1.00 14.17 ? 128 PRO A O 1 ATOM 723 C CB . PRO A 1 102 ? -8.890 -6.907 22.394 1.00 14.46 ? 128 PRO A CB 1 ATOM 724 C CG . PRO A 1 102 ? -7.715 -7.821 22.244 1.00 14.48 ? 128 PRO A CG 1 ATOM 725 C CD . PRO A 1 102 ? -8.296 -9.182 21.969 1.00 14.24 ? 128 PRO A CD 1 ATOM 726 N N . GLY A 1 103 ? -10.641 -6.057 19.560 1.00 14.51 ? 129 GLY A N 1 ATOM 727 C CA . GLY A 1 103 ? -10.360 -5.092 18.503 1.00 14.78 ? 129 GLY A CA 1 ATOM 728 C C . GLY A 1 103 ? -9.692 -3.943 19.231 1.00 14.87 ? 129 GLY A C 1 ATOM 729 O O . GLY A 1 103 ? -10.369 -3.107 19.822 1.00 15.15 ? 129 GLY A O 1 ATOM 730 N N . PHE A 1 104 ? -8.364 -3.924 19.219 1.00 15.03 ? 130 PHE A N 1 ATOM 731 C CA . PHE A 1 104 ? -7.611 -3.114 20.170 1.00 15.30 ? 130 PHE A CA 1 ATOM 732 C C . PHE A 1 104 ? -7.380 -1.692 19.671 1.00 15.28 ? 130 PHE A C 1 ATOM 733 O O . PHE A 1 104 ? -6.333 -1.369 19.112 1.00 15.35 ? 130 PHE A O 1 ATOM 734 C CB . PHE A 1 104 ? -6.280 -3.787 20.529 1.00 15.34 ? 130 PHE A CB 1 ATOM 735 C CG . PHE A 1 104 ? -5.781 -3.438 21.908 1.00 15.51 ? 130 PHE A CG 1 ATOM 736 C CD1 . PHE A 1 104 ? -5.478 -2.122 22.245 1.00 15.64 ? 130 PHE A CD1 1 ATOM 737 C CD2 . PHE A 1 104 ? -5.627 -4.423 22.870 1.00 15.41 ? 130 PHE A CD2 1 ATOM 738 C CE1 . PHE A 1 104 ? -5.025 -1.803 23.510 1.00 15.89 ? 130 PHE A CE1 1 ATOM 739 C CE2 . PHE A 1 104 ? -5.177 -4.111 24.136 1.00 15.61 ? 130 PHE A CE2 1 ATOM 740 C CZ . PHE A 1 104 ? -4.874 -2.799 24.458 1.00 15.95 ? 130 PHE A CZ 1 ATOM 741 N N . GLU A 1 105 ? -8.361 -0.836 19.898 1.00 15.29 ? 131 GLU A N 1 ATOM 742 C CA . GLU A 1 105 ? -8.209 0.565 19.564 1.00 15.83 ? 131 GLU A CA 1 ATOM 743 C C . GLU A 1 105 ? -7.280 1.206 20.589 1.00 15.56 ? 131 GLU A C 1 ATOM 744 O O . GLU A 1 105 ? -7.508 1.097 21.797 1.00 15.39 ? 131 GLU A O 1 ATOM 745 C CB . GLU A 1 105 ? -9.564 1.262 19.547 1.00 16.43 ? 131 GLU A CB 1 ATOM 746 C CG . GLU A 1 105 ? -10.482 0.754 18.454 1.00 16.95 ? 131 GLU A CG 1 ATOM 747 C CD . GLU A 1 105 ? -11.888 1.284 18.607 1.00 17.61 ? 131 GLU A CD 1 ATOM 748 O OE1 . GLU A 1 105 ? -12.592 0.846 19.539 1.00 17.50 ? 131 GLU A OE1 1 ATOM 749 O OE2 . GLU A 1 105 ? -12.282 2.139 17.792 1.00 18.77 ? 131 GLU A OE2 1 ATOM 750 N N . LEU A 1 106 ? -6.221 1.842 20.102 1.00 15.14 ? 132 LEU A N 1 ATOM 751 C CA . LEU A 1 106 ? -5.232 2.462 20.969 1.00 15.21 ? 132 LEU A CA 1 ATOM 752 C C . LEU A 1 106 ? -5.775 3.826 21.355 1.00 15.25 ? 132 LEU A C 1 ATOM 753 O O . LEU A 1 106 ? -5.328 4.858 20.852 1.00 15.41 ? 132 LEU A O 1 ATOM 754 C CB . LEU A 1 106 ? -3.877 2.550 20.266 1.00 15.17 ? 132 LEU A CB 1 ATOM 755 C CG . LEU A 1 106 ? -3.259 1.179 19.960 1.00 15.16 ? 132 LEU A CG 1 ATOM 756 C CD1 . LEU A 1 106 ? -2.118 1.303 18.961 1.00 15.22 ? 132 LEU A CD1 1 ATOM 757 C CD2 . LEU A 1 106 ? -2.784 0.497 21.238 1.00 15.18 ? 132 LEU A CD2 1 ATOM 758 N N . MET A 1 107 ? -6.738 3.800 22.272 1.00 14.93 ? 133 MET A N 1 ATOM 759 C CA . MET A 1 107 ? -7.656 4.907 22.486 1.00 15.12 ? 133 MET A CA 1 ATOM 760 C C . MET A 1 107 ? -7.792 5.228 23.974 1.00 15.42 ? 133 MET A C 1 ATOM 761 O O . MET A 1 107 ? -8.235 4.387 24.755 1.00 15.25 ? 133 MET A O 1 ATOM 762 C CB . MET A 1 107 ? -9.006 4.501 21.909 1.00 15.03 ? 133 MET A CB 1 ATOM 763 C CG . MET A 1 107 ? -10.068 5.580 21.858 1.00 14.94 ? 133 MET A CG 1 ATOM 764 S SD . MET A 1 107 ? -11.542 4.876 21.096 1.00 14.61 ? 133 MET A SD 1 ATOM 765 C CE . MET A 1 107 ? -12.734 6.168 21.438 1.00 15.00 ? 133 MET A CE 1 ATOM 766 N N . GLY A 1 108 ? -7.398 6.440 24.355 1.00 15.80 ? 134 GLY A N 1 ATOM 767 C CA . GLY A 1 108 ? -7.467 6.896 25.747 1.00 16.48 ? 134 GLY A CA 1 ATOM 768 C C . GLY A 1 108 ? -6.286 7.770 26.143 1.00 17.04 ? 134 GLY A C 1 ATOM 769 O O . GLY A 1 108 ? -5.326 7.930 25.375 1.00 17.01 ? 134 GLY A O 1 ATOM 770 N N . SER A 1 109 ? -6.356 8.320 27.353 1.00 17.58 ? 135 SER A N 1 ATOM 771 C CA . SER A 1 109 ? -5.352 9.262 27.858 1.00 18.03 ? 135 SER A CA 1 ATOM 772 C C . SER A 1 109 ? -4.516 8.700 29.002 1.00 18.49 ? 135 SER A C 1 ATOM 773 O O . SER A 1 109 ? -3.694 9.422 29.569 1.00 18.61 ? 135 SER A O 1 ATOM 774 C CB . SER A 1 109 ? -6.047 10.531 28.355 1.00 18.14 ? 135 SER A CB 1 ATOM 775 O OG . SER A 1 109 ? -6.746 10.285 29.565 1.00 18.12 ? 135 SER A OG 1 ATOM 776 N N . ALA A 1 110 ? -4.731 7.427 29.342 1.00 18.93 ? 136 ALA A N 1 ATOM 777 C CA . ALA A 1 110 ? -4.114 6.799 30.515 1.00 19.46 ? 136 ALA A CA 1 ATOM 778 C C . ALA A 1 110 ? -4.377 7.641 31.763 1.00 20.31 ? 136 ALA A C 1 ATOM 779 O O . ALA A 1 110 ? -3.446 8.137 32.399 1.00 20.20 ? 136 ALA A O 1 ATOM 780 C CB . ALA A 1 110 ? -2.619 6.578 30.298 1.00 19.25 ? 136 ALA A CB 1 ATOM 781 N N . SER A 1 111 ? -5.664 7.801 32.076 1.00 21.33 ? 137 SER A N 1 ATOM 782 C CA . SER A 1 111 ? -6.140 8.583 33.220 1.00 21.78 ? 137 SER A CA 1 ATOM 783 C C . SER A 1 111 ? -5.593 10.011 33.246 1.00 21.83 ? 137 SER A C 1 ATOM 784 O O . SER A 1 111 ? -5.182 10.500 34.295 1.00 22.16 ? 137 SER A O 1 ATOM 785 C CB . SER A 1 111 ? -5.814 7.871 34.538 1.00 22.44 ? 137 SER A CB 1 ATOM 786 O OG . SER A 1 111 ? -4.459 8.078 34.923 1.00 23.23 ? 137 SER A OG 1 ATOM 787 N N . GLY A 1 112 ? -5.584 10.668 32.090 1.00 21.32 ? 138 GLY A N 1 ATOM 788 C CA . GLY A 1 112 ? -5.265 12.091 32.013 1.00 20.78 ? 138 GLY A CA 1 ATOM 789 C C . GLY A 1 112 ? -3.798 12.446 31.866 1.00 20.53 ? 138 GLY A C 1 ATOM 790 O O . GLY A 1 112 ? -3.443 13.629 31.922 1.00 20.92 ? 138 GLY A O 1 ATOM 791 N N . HIS A 1 113 ? -2.935 11.451 31.668 1.00 19.57 ? 139 HIS A N 1 ATOM 792 C CA . HIS A 1 113 ? -1.519 11.737 31.459 1.00 19.38 ? 139 HIS A CA 1 ATOM 793 C C . HIS A 1 113 ? -1.276 12.381 30.099 1.00 19.11 ? 139 HIS A C 1 ATOM 794 O O . HIS A 1 113 ? -0.542 13.361 30.001 1.00 19.38 ? 139 HIS A O 1 ATOM 795 C CB . HIS A 1 113 ? -0.644 10.489 31.589 1.00 19.21 ? 139 HIS A CB 1 ATOM 796 C CG . HIS A 1 113 ? 0.793 10.747 31.260 1.00 19.75 ? 139 HIS A CG 1 ATOM 797 N ND1 . HIS A 1 113 ? 1.658 11.365 32.137 1.00 19.72 ? 139 HIS A ND1 1 ATOM 798 C CD2 . HIS A 1 113 ? 1.506 10.513 30.131 1.00 20.07 ? 139 HIS A CD2 1 ATOM 799 C CE1 . HIS A 1 113 ? 2.845 11.485 31.570 1.00 20.02 ? 139 HIS A CE1 1 ATOM 800 N NE2 . HIS A 1 113 ? 2.780 10.978 30.352 1.00 20.00 ? 139 HIS A NE2 1 ATOM 801 N N . PHE A 1 114 ? -1.884 11.825 29.051 1.00 18.65 ? 140 PHE A N 1 ATOM 802 C CA . PHE A 1 114 ? -1.670 12.322 27.692 1.00 17.99 ? 140 PHE A CA 1 ATOM 803 C C . PHE A 1 114 ? -2.665 13.429 27.366 1.00 17.92 ? 140 PHE A C 1 ATOM 804 O O . PHE A 1 114 ? -3.871 13.248 27.524 1.00 17.83 ? 140 PHE A O 1 ATOM 805 C CB . PHE A 1 114 ? -1.729 11.173 26.682 1.00 17.65 ? 140 PHE A CB 1 ATOM 806 C CG . PHE A 1 114 ? -0.620 10.170 26.866 1.00 17.27 ? 140 PHE A CG 1 ATOM 807 C CD1 . PHE A 1 114 ? 0.652 10.423 26.363 1.00 17.25 ? 140 PHE A CD1 1 ATOM 808 C CD2 . PHE A 1 114 ? -0.832 9.002 27.581 1.00 17.08 ? 140 PHE A CD2 1 ATOM 809 C CE1 . PHE A 1 114 ? 1.683 9.515 26.549 1.00 17.00 ? 140 PHE A CE1 1 ATOM 810 C CE2 . PHE A 1 114 ? 0.194 8.086 27.770 1.00 17.07 ? 140 PHE A CE2 1 ATOM 811 C CZ . PHE A 1 114 ? 1.456 8.343 27.253 1.00 17.12 ? 140 PHE A CZ 1 ATOM 812 N N . THR A 1 115 ? -2.137 14.583 26.953 1.00 17.74 ? 141 THR A N 1 ATOM 813 C CA . THR A 1 115 ? -2.946 15.769 26.662 1.00 17.92 ? 141 THR A CA 1 ATOM 814 C C . THR A 1 115 ? -2.636 16.446 25.320 1.00 17.92 ? 141 THR A C 1 ATOM 815 O O . THR A 1 115 ? -3.430 17.258 24.858 1.00 17.95 ? 141 THR A O 1 ATOM 816 C CB . THR A 1 115 ? -2.757 16.841 27.756 1.00 17.97 ? 141 THR A CB 1 ATOM 817 O OG1 . THR A 1 115 ? -1.369 17.181 27.856 1.00 18.27 ? 141 THR A OG1 1 ATOM 818 C CG2 . THR A 1 115 ? -3.253 16.342 29.111 1.00 17.93 ? 141 THR A CG2 1 ATOM 819 N N . ASP A 1 116 ? -1.497 16.136 24.696 1.00 18.10 ? 142 ASP A N 1 ATOM 820 C CA . ASP A 1 116 ? -1.047 16.906 23.531 1.00 18.28 ? 142 ASP A CA 1 ATOM 821 C C . ASP A 1 116 ? -0.077 16.116 22.654 1.00 18.01 ? 142 ASP A C 1 ATOM 822 O O . ASP A 1 116 ? 1.069 15.883 23.033 1.00 17.97 ? 142 ASP A O 1 ATOM 823 C CB . ASP A 1 116 ? -0.391 18.210 24.006 1.00 18.69 ? 142 ASP A CB 1 ATOM 824 C CG . ASP A 1 116 ? -0.107 19.182 22.875 1.00 19.23 ? 142 ASP A CG 1 ATOM 825 O OD1 . ASP A 1 116 ? -0.257 18.825 21.685 1.00 19.67 ? 142 ASP A OD1 1 ATOM 826 O OD2 . ASP A 1 116 ? 0.277 20.326 23.185 1.00 20.24 ? 142 ASP A OD2 1 ATOM 827 N N . PHE A 1 117 ? -0.535 15.726 21.467 1.00 17.90 ? 143 PHE A N 1 ATOM 828 C CA . PHE A 1 117 ? 0.286 14.915 20.570 1.00 17.70 ? 143 PHE A CA 1 ATOM 829 C C . PHE A 1 117 ? 1.157 15.732 19.609 1.00 17.67 ? 143 PHE A C 1 ATOM 830 O O . PHE A 1 117 ? 1.733 15.179 18.671 1.00 17.35 ? 143 PHE A O 1 ATOM 831 C CB . PHE A 1 117 ? -0.579 13.886 19.834 1.00 17.45 ? 143 PHE A CB 1 ATOM 832 C CG . PHE A 1 117 ? -0.911 12.689 20.671 1.00 17.15 ? 143 PHE A CG 1 ATOM 833 C CD1 . PHE A 1 117 ? 0.036 11.702 20.887 1.00 17.00 ? 143 PHE A CD1 1 ATOM 834 C CD2 . PHE A 1 117 ? -2.156 12.561 21.268 1.00 17.23 ? 143 PHE A CD2 1 ATOM 835 C CE1 . PHE A 1 117 ? -0.256 10.602 21.670 1.00 17.04 ? 143 PHE A CE1 1 ATOM 836 C CE2 . PHE A 1 117 ? -2.454 11.464 22.053 1.00 17.15 ? 143 PHE A CE2 1 ATOM 837 C CZ . PHE A 1 117 ? -1.504 10.483 22.254 1.00 16.98 ? 143 PHE A CZ 1 ATOM 838 N N . GLU A 1 118 ? 1.263 17.038 19.850 1.00 18.07 ? 144 GLU A N 1 ATOM 839 C CA . GLU A 1 118 ? 2.330 17.848 19.245 1.00 18.88 ? 144 GLU A CA 1 ATOM 840 C C . GLU A 1 118 ? 3.433 18.177 20.254 1.00 18.74 ? 144 GLU A C 1 ATOM 841 O O . GLU A 1 118 ? 4.433 18.790 19.898 1.00 19.16 ? 144 GLU A O 1 ATOM 842 C CB . GLU A 1 118 ? 1.767 19.120 18.610 1.00 19.37 ? 144 GLU A CB 1 ATOM 843 C CG . GLU A 1 118 ? 0.997 18.842 17.325 1.00 20.08 ? 144 GLU A CG 1 ATOM 844 C CD . GLU A 1 118 ? 0.718 20.095 16.515 1.00 20.73 ? 144 GLU A CD 1 ATOM 845 O OE1 . GLU A 1 118 ? -0.453 20.347 16.192 1.00 21.31 ? 144 GLU A OE1 1 ATOM 846 O OE2 . GLU A 1 118 ? 1.671 20.834 16.201 1.00 22.06 ? 144 GLU A OE2 1 ATOM 847 N N . ASP A 1 119 ? 3.240 17.774 21.509 1.00 19.10 ? 145 ASP A N 1 ATOM 848 C CA . ASP A 1 119 ? 4.301 17.779 22.519 1.00 19.00 ? 145 ASP A CA 1 ATOM 849 C C . ASP A 1 119 ? 5.168 16.550 22.255 1.00 18.85 ? 145 ASP A C 1 ATOM 850 O O . ASP A 1 119 ? 4.737 15.414 22.487 1.00 18.15 ? 145 ASP A O 1 ATOM 851 C CB . ASP A 1 119 ? 3.686 17.737 23.925 1.00 19.70 ? 145 ASP A CB 1 ATOM 852 C CG . ASP A 1 119 ? 4.728 17.740 25.044 1.00 20.40 ? 145 ASP A CG 1 ATOM 853 O OD1 . ASP A 1 119 ? 5.944 17.701 24.765 1.00 20.75 ? 145 ASP A OD1 1 ATOM 854 O OD2 . ASP A 1 119 ? 4.313 17.778 26.220 1.00 20.91 ? 145 ASP A OD2 1 ATOM 855 N N . LYS A 1 120 ? 6.380 16.792 21.757 1.00 18.55 ? 146 LYS A N 1 ATOM 856 C CA . LYS A 1 120 ? 7.293 15.739 21.303 1.00 18.69 ? 146 LYS A CA 1 ATOM 857 C C . LYS A 1 120 ? 7.518 14.636 22.343 1.00 18.01 ? 146 LYS A C 1 ATOM 858 O O . LYS A 1 120 ? 7.574 13.455 21.995 1.00 17.85 ? 146 LYS A O 1 ATOM 859 C CB . LYS A 1 120 ? 8.636 16.363 20.894 1.00 19.58 ? 146 LYS A CB 1 ATOM 860 C CG . LYS A 1 120 ? 9.755 15.370 20.585 1.00 20.95 ? 146 LYS A CG 1 ATOM 861 C CD . LYS A 1 120 ? 11.025 16.079 20.114 1.00 22.04 ? 146 LYS A CD 1 ATOM 862 C CE . LYS A 1 120 ? 12.122 15.089 19.742 1.00 22.91 ? 146 LYS A CE 1 ATOM 863 N NZ . LYS A 1 120 ? 13.454 15.749 19.590 1.00 23.35 ? 146 LYS A NZ 1 ATOM 864 N N . GLN A 1 121 ? 7.646 15.022 23.608 1.00 17.13 ? 147 GLN A N 1 ATOM 865 C CA . GLN A 1 121 ? 7.934 14.068 24.678 1.00 16.76 ? 147 GLN A CA 1 ATOM 866 C C . GLN A 1 121 ? 6.765 13.129 24.965 1.00 16.03 ? 147 GLN A C 1 ATOM 867 O O . GLN A 1 121 ? 6.975 11.960 25.260 1.00 15.56 ? 147 GLN A O 1 ATOM 868 C CB . GLN A 1 121 ? 8.337 14.799 25.964 1.00 16.69 ? 147 GLN A CB 1 ATOM 869 C CG . GLN A 1 121 ? 8.833 13.873 27.066 1.00 16.86 ? 147 GLN A CG 1 ATOM 870 C CD . GLN A 1 121 ? 10.005 13.022 26.625 1.00 17.02 ? 147 GLN A CD 1 ATOM 871 O OE1 . GLN A 1 121 ? 10.729 13.383 25.702 1.00 17.47 ? 147 GLN A OE1 1 ATOM 872 N NE2 . GLN A 1 121 ? 10.197 11.886 27.280 1.00 17.43 ? 147 GLN A NE2 1 ATOM 873 N N . GLN A 1 122 ? 5.544 13.651 24.884 1.00 15.79 ? 148 GLN A N 1 ATOM 874 C CA . GLN A 1 122 ? 4.337 12.823 24.973 1.00 15.69 ? 148 GLN A CA 1 ATOM 875 C C . GLN A 1 122 ? 4.246 11.793 23.843 1.00 15.41 ? 148 GLN A C 1 ATOM 876 O O . GLN A 1 122 ? 3.817 10.659 24.063 1.00 15.17 ? 148 GLN A O 1 ATOM 877 C CB . GLN A 1 122 ? 3.082 13.695 24.984 1.00 15.78 ? 148 GLN A CB 1 ATOM 878 C CG . GLN A 1 122 ? 2.947 14.518 26.253 1.00 15.89 ? 148 GLN A CG 1 ATOM 879 C CD . GLN A 1 122 ? 1.626 15.260 26.342 1.00 16.03 ? 148 GLN A CD 1 ATOM 880 O OE1 . GLN A 1 122 ? 0.556 14.684 26.135 1.00 15.75 ? 148 GLN A OE1 1 ATOM 881 N NE2 . GLN A 1 122 ? 1.694 16.548 26.666 1.00 16.38 ? 148 GLN A NE2 1 ATOM 882 N N . VAL A 1 123 ? 4.666 12.186 22.643 1.00 15.14 ? 149 VAL A N 1 ATOM 883 C CA . VAL A 1 123 ? 4.660 11.280 21.499 1.00 14.93 ? 149 VAL A CA 1 ATOM 884 C C . VAL A 1 123 ? 5.611 10.108 21.772 1.00 14.70 ? 149 VAL A C 1 ATOM 885 O O . VAL A 1 123 ? 5.274 8.953 21.506 1.00 14.64 ? 149 VAL A O 1 ATOM 886 C CB . VAL A 1 123 ? 5.041 11.999 20.183 1.00 14.74 ? 149 VAL A CB 1 ATOM 887 C CG1 . VAL A 1 123 ? 5.059 11.016 19.020 1.00 14.84 ? 149 VAL A CG1 1 ATOM 888 C CG2 . VAL A 1 123 ? 4.073 13.130 19.888 1.00 14.63 ? 149 VAL A CG2 1 ATOM 889 N N . PHE A 1 124 ? 6.785 10.412 22.320 1.00 14.56 ? 150 PHE A N 1 ATOM 890 C CA . PHE A 1 124 ? 7.742 9.375 22.717 1.00 14.42 ? 150 PHE A CA 1 ATOM 891 C C . PHE A 1 124 ? 7.196 8.511 23.853 1.00 14.62 ? 150 PHE A C 1 ATOM 892 O O . PHE A 1 124 ? 7.335 7.286 23.828 1.00 14.68 ? 150 PHE A O 1 ATOM 893 C CB . PHE A 1 124 ? 9.092 9.990 23.100 1.00 14.37 ? 150 PHE A CB 1 ATOM 894 C CG . PHE A 1 124 ? 10.013 10.206 21.929 1.00 14.16 ? 150 PHE A CG 1 ATOM 895 C CD1 . PHE A 1 124 ? 9.960 11.376 21.191 1.00 14.06 ? 150 PHE A CD1 1 ATOM 896 C CD2 . PHE A 1 124 ? 10.917 9.225 21.555 1.00 14.08 ? 150 PHE A CD2 1 ATOM 897 C CE1 . PHE A 1 124 ? 10.801 11.572 20.114 1.00 13.91 ? 150 PHE A CE1 1 ATOM 898 C CE2 . PHE A 1 124 ? 11.762 9.413 20.475 1.00 13.99 ? 150 PHE A CE2 1 ATOM 899 C CZ . PHE A 1 124 ? 11.705 10.592 19.755 1.00 13.90 ? 150 PHE A CZ 1 ATOM 900 N N . GLU A 1 125 ? 6.561 9.146 24.836 1.00 14.80 ? 151 GLU A N 1 ATOM 901 C CA . GLU A 1 125 ? 5.917 8.411 25.932 1.00 15.10 ? 151 GLU A CA 1 ATOM 902 C C . GLU A 1 125 ? 4.793 7.496 25.439 1.00 14.91 ? 151 GLU A C 1 ATOM 903 O O . GLU A 1 125 ? 4.632 6.396 25.954 1.00 14.68 ? 151 GLU A O 1 ATOM 904 C CB . GLU A 1 125 ? 5.398 9.373 27.015 1.00 15.49 ? 151 GLU A CB 1 ATOM 905 C CG . GLU A 1 125 ? 6.511 9.936 27.893 1.00 15.75 ? 151 GLU A CG 1 ATOM 906 C CD . GLU A 1 125 ? 6.079 11.109 28.763 1.00 15.96 ? 151 GLU A CD 1 ATOM 907 O OE1 . GLU A 1 125 ? 4.913 11.548 28.673 1.00 16.30 ? 151 GLU A OE1 1 ATOM 908 O OE2 . GLU A 1 125 ? 6.914 11.594 29.553 1.00 16.27 ? 151 GLU A OE2 1 ATOM 909 N N . TRP A 1 126 ? 4.037 7.943 24.434 1.00 14.98 ? 152 TRP A N 1 ATOM 910 C CA . TRP A 1 126 ? 2.964 7.126 23.857 1.00 14.93 ? 152 TRP A CA 1 ATOM 911 C C . TRP A 1 126 ? 3.528 5.887 23.181 1.00 14.92 ? 152 TRP A C 1 ATOM 912 O O . TRP A 1 126 ? 3.013 4.783 23.363 1.00 14.80 ? 152 TRP A O 1 ATOM 913 C CB . TRP A 1 126 ? 2.124 7.922 22.854 1.00 14.87 ? 152 TRP A CB 1 ATOM 914 C CG . TRP A 1 126 ? 0.901 7.178 22.387 1.00 14.93 ? 152 TRP A CG 1 ATOM 915 C CD1 . TRP A 1 126 ? 0.769 6.446 21.241 1.00 14.99 ? 152 TRP A CD1 1 ATOM 916 C CD2 . TRP A 1 126 ? -0.350 7.076 23.072 1.00 15.01 ? 152 TRP A CD2 1 ATOM 917 N NE1 . TRP A 1 126 ? -0.494 5.900 21.169 1.00 14.97 ? 152 TRP A NE1 1 ATOM 918 C CE2 . TRP A 1 126 ? -1.199 6.272 22.280 1.00 15.04 ? 152 TRP A CE2 1 ATOM 919 C CE3 . TRP A 1 126 ? -0.842 7.595 24.275 1.00 15.06 ? 152 TRP A CE3 1 ATOM 920 C CZ2 . TRP A 1 126 ? -2.511 5.980 22.651 1.00 15.13 ? 152 TRP A CZ2 1 ATOM 921 C CZ3 . TRP A 1 126 ? -2.149 7.301 24.642 1.00 15.07 ? 152 TRP A CZ3 1 ATOM 922 C CH2 . TRP A 1 126 ? -2.966 6.504 23.831 1.00 15.12 ? 152 TRP A CH2 1 ATOM 923 N N . LYS A 1 127 ? 4.585 6.073 22.398 1.00 15.20 ? 153 LYS A N 1 ATOM 924 C CA . LYS A 1 127 ? 5.257 4.954 21.751 1.00 15.45 ? 153 LYS A CA 1 ATOM 925 C C . LYS A 1 127 ? 5.646 3.892 22.785 1.00 15.59 ? 153 LYS A C 1 ATOM 926 O O . LYS A 1 127 ? 5.459 2.697 22.555 1.00 15.67 ? 153 LYS A O 1 ATOM 927 C CB . LYS A 1 127 ? 6.492 5.437 20.974 1.00 15.63 ? 153 LYS A CB 1 ATOM 928 C CG . LYS A 1 127 ? 7.420 4.317 20.500 1.00 15.97 ? 153 LYS A CG 1 ATOM 929 C CD . LYS A 1 127 ? 8.645 4.847 19.760 1.00 16.23 ? 153 LYS A CD 1 ATOM 930 C CE . LYS A 1 127 ? 9.645 5.538 20.684 1.00 16.43 ? 153 LYS A CE 1 ATOM 931 N NZ . LYS A 1 127 ? 10.389 4.591 21.566 1.00 16.57 ? 153 LYS A NZ 1 ATOM 932 N N . ASP A 1 128 ? 6.178 4.331 23.921 1.00 15.73 ? 154 ASP A N 1 ATOM 933 C CA . ASP A 1 128 ? 6.643 3.399 24.954 1.00 15.98 ? 154 ASP A CA 1 ATOM 934 C C . ASP A 1 128 ? 5.496 2.746 25.722 1.00 15.50 ? 154 ASP A C 1 ATOM 935 O O . ASP A 1 128 ? 5.587 1.580 26.091 1.00 15.12 ? 154 ASP A O 1 ATOM 936 C CB . ASP A 1 128 ? 7.630 4.087 25.902 1.00 16.26 ? 154 ASP A CB 1 ATOM 937 C CG . ASP A 1 128 ? 8.921 4.484 25.199 1.00 16.95 ? 154 ASP A CG 1 ATOM 938 O OD1 . ASP A 1 128 ? 9.102 4.126 24.008 1.00 17.47 ? 154 ASP A OD1 1 ATOM 939 O OD2 . ASP A 1 128 ? 9.758 5.158 25.831 1.00 17.80 ? 154 ASP A OD2 1 ATOM 940 N N . LEU A 1 129 ? 4.418 3.489 25.946 1.00 15.40 ? 155 LEU A N 1 ATOM 941 C CA . LEU A 1 129 ? 3.194 2.903 26.488 1.00 15.37 ? 155 LEU A CA 1 ATOM 942 C C . LEU A 1 129 ? 2.737 1.750 25.597 1.00 15.25 ? 155 LEU A C 1 ATOM 943 O O . LEU A 1 129 ? 2.452 0.670 26.087 1.00 15.21 ? 155 LEU A O 1 ATOM 944 C CB . LEU A 1 129 ? 2.079 3.950 26.608 1.00 15.31 ? 155 LEU A CB 1 ATOM 945 C CG . LEU A 1 129 ? 0.673 3.407 26.906 1.00 15.41 ? 155 LEU A CG 1 ATOM 946 C CD1 . LEU A 1 129 ? 0.669 2.537 28.158 1.00 15.41 ? 155 LEU A CD1 1 ATOM 947 C CD2 . LEU A 1 129 ? -0.330 4.545 27.043 1.00 15.49 ? 155 LEU A CD2 1 ATOM 948 N N . VAL A 1 130 ? 2.695 1.985 24.287 1.00 15.33 ? 156 VAL A N 1 ATOM 949 C CA . VAL A 1 130 ? 2.197 0.983 23.341 1.00 15.38 ? 156 VAL A CA 1 ATOM 950 C C . VAL A 1 130 ? 3.109 -0.247 23.294 1.00 15.51 ? 156 VAL A C 1 ATOM 951 O O . VAL A 1 130 ? 2.625 -1.372 23.376 1.00 15.26 ? 156 VAL A O 1 ATOM 952 C CB . VAL A 1 130 ? 1.975 1.579 21.930 1.00 15.17 ? 156 VAL A CB 1 ATOM 953 C CG1 . VAL A 1 130 ? 1.687 0.489 20.915 1.00 15.38 ? 156 VAL A CG1 1 ATOM 954 C CG2 . VAL A 1 130 ? 0.821 2.575 21.951 1.00 15.14 ? 156 VAL A CG2 1 ATOM 955 N N . SER A 1 131 ? 4.417 -0.046 23.178 1.00 15.89 ? 157 SER A N 1 ATOM 956 C CA . SER A 1 131 ? 5.346 -1.182 23.195 1.00 16.42 ? 157 SER A CA 1 ATOM 957 C C . SER A 1 131 ? 5.299 -1.892 24.548 1.00 16.28 ? 157 SER A C 1 ATOM 958 O O . SER A 1 131 ? 5.408 -3.114 24.624 1.00 16.12 ? 157 SER A O 1 ATOM 959 C CB . SER A 1 131 ? 6.777 -0.742 22.870 1.00 16.76 ? 157 SER A CB 1 ATOM 960 O OG . SER A 1 131 ? 7.263 0.132 23.856 1.00 18.12 ? 157 SER A OG 1 ATOM 961 N N . SER A 1 132 ? 5.111 -1.119 25.612 1.00 16.43 ? 158 SER A N 1 ATOM 962 C CA . SER A 1 132 ? 5.007 -1.676 26.953 1.00 16.64 ? 158 SER A CA 1 ATOM 963 C C . SER A 1 132 ? 3.747 -2.538 27.094 1.00 16.53 ? 158 SER A C 1 ATOM 964 O O . SER A 1 132 ? 3.811 -3.653 27.611 1.00 16.50 ? 158 SER A O 1 ATOM 965 C CB . SER A 1 132 ? 5.032 -0.549 27.987 1.00 16.91 ? 158 SER A CB 1 ATOM 966 O OG . SER A 1 132 ? 5.050 -1.054 29.295 1.00 17.76 ? 158 SER A OG 1 ATOM 967 N N . LEU A 1 133 ? 2.609 -2.052 26.606 1.00 16.42 ? 159 LEU A N 1 ATOM 968 C CA . LEU A 1 133 ? 1.382 -2.847 26.689 1.00 16.36 ? 159 LEU A CA 1 ATOM 969 C C . LEU A 1 133 ? 1.435 -4.071 25.761 1.00 16.13 ? 159 LEU A C 1 ATOM 970 O O . LEU A 1 133 ? 1.012 -5.156 26.149 1.00 15.46 ? 159 LEU A O 1 ATOM 971 C CB . LEU A 1 133 ? 0.131 -1.987 26.448 1.00 16.76 ? 159 LEU A CB 1 ATOM 972 C CG . LEU A 1 133 ? -0.331 -1.626 25.036 1.00 17.03 ? 159 LEU A CG 1 ATOM 973 C CD1 . LEU A 1 133 ? -1.245 -2.694 24.448 1.00 17.14 ? 159 LEU A CD1 1 ATOM 974 C CD2 . LEU A 1 133 ? -1.055 -0.285 25.059 1.00 17.36 ? 159 LEU A CD2 1 ATOM 975 N N . ALA A 1 134 ? 1.976 -3.902 24.555 1.00 16.16 ? 160 ALA A N 1 ATOM 976 C CA . ALA A 1 134 ? 2.084 -5.009 23.596 1.00 16.25 ? 160 ALA A CA 1 ATOM 977 C C . ALA A 1 134 ? 2.985 -6.141 24.115 1.00 16.34 ? 160 ALA A C 1 ATOM 978 O O . ALA A 1 134 ? 2.642 -7.319 23.994 1.00 15.99 ? 160 ALA A O 1 ATOM 979 C CB . ALA A 1 134 ? 2.590 -4.504 22.254 1.00 16.27 ? 160 ALA A CB 1 ATOM 980 N N . ARG A 1 135 ? 4.129 -5.776 24.688 1.00 16.62 ? 161 ARG A N 1 ATOM 981 C CA . ARG A 1 135 ? 5.026 -6.749 25.327 1.00 17.01 ? 161 ARG A CA 1 ATOM 982 C C . ARG A 1 135 ? 4.371 -7.447 26.507 1.00 16.42 ? 161 ARG A C 1 ATOM 983 O O . ARG A 1 135 ? 4.531 -8.651 26.689 1.00 15.93 ? 161 ARG A O 1 ATOM 984 C CB . ARG A 1 135 ? 6.305 -6.073 25.820 1.00 17.74 ? 161 ARG A CB 1 ATOM 985 C CG . ARG A 1 135 ? 7.280 -5.718 24.718 1.00 18.69 ? 161 ARG A CG 1 ATOM 986 C CD . ARG A 1 135 ? 8.446 -4.931 25.282 1.00 19.65 ? 161 ARG A CD 1 ATOM 987 N NE . ARG A 1 135 ? 9.450 -4.667 24.253 1.00 20.67 ? 161 ARG A NE 1 ATOM 988 C CZ . ARG A 1 135 ? 9.974 -3.475 23.965 1.00 21.36 ? 161 ARG A CZ 1 ATOM 989 N NH1 . ARG A 1 135 ? 9.616 -2.382 24.636 1.00 22.42 ? 161 ARG A NH1 1 ATOM 990 N NH2 . ARG A 1 135 ? 10.879 -3.378 23.000 1.00 21.33 ? 161 ARG A NH2 1 ATOM 991 N N . ARG A 1 136 ? 3.648 -6.685 27.322 1.00 16.17 ? 162 ARG A N 1 ATOM 992 C CA . ARG A 1 136 ? 2.968 -7.257 28.471 1.00 15.83 ? 162 ARG A CA 1 ATOM 993 C C . ARG A 1 136 ? 2.043 -8.394 28.039 1.00 15.75 ? 162 ARG A C 1 ATOM 994 O O . ARG A 1 136 ? 2.049 -9.469 28.650 1.00 15.70 ? 162 ARG A O 1 ATOM 995 C CB . ARG A 1 136 ? 2.172 -6.194 29.225 1.00 16.05 ? 162 ARG A CB 1 ATOM 996 C CG . ARG A 1 136 ? 1.444 -6.747 30.434 1.00 16.30 ? 162 ARG A CG 1 ATOM 997 C CD . ARG A 1 136 ? 0.687 -5.685 31.204 1.00 16.45 ? 162 ARG A CD 1 ATOM 998 N NE . ARG A 1 136 ? 0.052 -6.284 32.373 1.00 16.89 ? 162 ARG A NE 1 ATOM 999 C CZ . ARG A 1 136 ? 0.682 -6.579 33.510 1.00 17.23 ? 162 ARG A CZ 1 ATOM 1000 N NH1 . ARG A 1 136 ? 1.977 -6.324 33.661 1.00 17.28 ? 162 ARG A NH1 1 ATOM 1001 N NH2 . ARG A 1 136 ? 0.011 -7.134 34.512 1.00 17.37 ? 162 ARG A NH2 1 ATOM 1002 N N . TYR A 1 137 ? 1.254 -8.165 26.993 1.00 15.14 ? 163 TYR A N 1 ATOM 1003 C CA . TYR A 1 137 ? 0.250 -9.152 26.596 1.00 15.10 ? 163 TYR A CA 1 ATOM 1004 C C . TYR A 1 137 ? 0.808 -10.246 25.681 1.00 15.24 ? 163 TYR A C 1 ATOM 1005 O O . TYR A 1 137 ? 0.304 -11.366 25.688 1.00 15.06 ? 163 TYR A O 1 ATOM 1006 C CB . TYR A 1 137 ? -1.008 -8.459 26.054 1.00 14.92 ? 163 TYR A CB 1 ATOM 1007 C CG . TYR A 1 137 ? -1.634 -7.597 27.130 1.00 14.67 ? 163 TYR A CG 1 ATOM 1008 C CD1 . TYR A 1 137 ? -2.072 -8.165 28.323 1.00 14.58 ? 163 TYR A CD1 1 ATOM 1009 C CD2 . TYR A 1 137 ? -1.743 -6.219 26.983 1.00 14.47 ? 163 TYR A CD2 1 ATOM 1010 C CE1 . TYR A 1 137 ? -2.613 -7.391 29.331 1.00 14.51 ? 163 TYR A CE1 1 ATOM 1011 C CE2 . TYR A 1 137 ? -2.286 -5.436 27.985 1.00 14.52 ? 163 TYR A CE2 1 ATOM 1012 C CZ . TYR A 1 137 ? -2.713 -6.028 29.160 1.00 14.59 ? 163 TYR A CZ 1 ATOM 1013 O OH . TYR A 1 137 ? -3.257 -5.259 30.161 1.00 14.92 ? 163 TYR A OH 1 ATOM 1014 N N . ILE A 1 138 ? 1.872 -9.945 24.939 1.00 15.80 ? 164 ILE A N 1 ATOM 1015 C CA . ILE A 1 138 ? 2.681 -11.000 24.310 1.00 16.20 ? 164 ILE A CA 1 ATOM 1016 C C . ILE A 1 138 ? 3.179 -11.975 25.384 1.00 16.55 ? 164 ILE A C 1 ATOM 1017 O O . ILE A 1 138 ? 3.144 -13.191 25.195 1.00 16.41 ? 164 ILE A O 1 ATOM 1018 C CB . ILE A 1 138 ? 3.894 -10.425 23.544 1.00 16.25 ? 164 ILE A CB 1 ATOM 1019 C CG1 . ILE A 1 138 ? 3.440 -9.800 22.221 1.00 16.27 ? 164 ILE A CG1 1 ATOM 1020 C CG2 . ILE A 1 138 ? 4.940 -11.507 23.272 1.00 16.28 ? 164 ILE A CG2 1 ATOM 1021 C CD1 . ILE A 1 138 ? 4.450 -8.836 21.628 1.00 16.30 ? 164 ILE A CD1 1 ATOM 1022 N N . GLY A 1 139 ? 3.650 -11.427 26.502 1.00 16.86 ? 165 GLY A N 1 ATOM 1023 C CA . GLY A 1 139 ? 4.081 -12.232 27.635 1.00 17.21 ? 165 GLY A CA 1 ATOM 1024 C C . GLY A 1 139 ? 2.943 -12.994 28.289 1.00 17.67 ? 165 GLY A C 1 ATOM 1025 O O . GLY A 1 139 ? 3.101 -14.168 28.616 1.00 17.87 ? 165 GLY A O 1 ATOM 1026 N N . ARG A 1 140 ? 1.796 -12.339 28.470 1.00 17.88 ? 166 ARG A N 1 ATOM 1027 C CA . ARG A 1 140 ? 0.656 -12.960 29.152 1.00 18.62 ? 166 ARG A CA 1 ATOM 1028 C C . ARG A 1 140 ? -0.092 -13.986 28.285 1.00 18.64 ? 166 ARG A C 1 ATOM 1029 O O . ARG A 1 140 ? -0.606 -14.981 28.805 1.00 18.56 ? 166 ARG A O 1 ATOM 1030 C CB . ARG A 1 140 ? -0.322 -11.892 29.655 1.00 19.29 ? 166 ARG A CB 1 ATOM 1031 C CG . ARG A 1 140 ? -1.519 -12.459 30.407 1.00 20.08 ? 166 ARG A CG 1 ATOM 1032 C CD . ARG A 1 140 ? -2.391 -11.373 31.022 1.00 20.80 ? 166 ARG A CD 1 ATOM 1033 N NE . ARG A 1 140 ? -1.792 -10.910 32.266 1.00 21.68 ? 166 ARG A NE 1 ATOM 1034 C CZ . ARG A 1 140 ? -2.392 -10.827 33.450 1.00 22.07 ? 166 ARG A CZ 1 ATOM 1035 N NH1 . ARG A 1 140 ? -3.668 -11.144 33.625 1.00 21.92 ? 166 ARG A NH1 1 ATOM 1036 N NH2 . ARG A 1 140 ? -1.687 -10.395 34.481 1.00 23.13 ? 166 ARG A NH2 1 ATOM 1037 N N . TYR A 1 141 ? -0.158 -13.751 26.976 1.00 18.32 ? 167 TYR A N 1 ATOM 1038 C CA . TYR A 1 141 ? -0.955 -14.603 26.086 1.00 18.02 ? 167 TYR A CA 1 ATOM 1039 C C . TYR A 1 141 ? -0.161 -15.309 24.974 1.00 17.70 ? 167 TYR A C 1 ATOM 1040 O O . TYR A 1 141 ? -0.695 -16.206 24.321 1.00 17.76 ? 167 TYR A O 1 ATOM 1041 C CB . TYR A 1 141 ? -2.087 -13.784 25.446 1.00 18.04 ? 167 TYR A CB 1 ATOM 1042 C CG . TYR A 1 141 ? -2.966 -13.017 26.417 1.00 17.89 ? 167 TYR A CG 1 ATOM 1043 C CD1 . TYR A 1 141 ? -3.515 -13.634 27.543 1.00 18.21 ? 167 TYR A CD1 1 ATOM 1044 C CD2 . TYR A 1 141 ? -3.277 -11.681 26.193 1.00 17.97 ? 167 TYR A CD2 1 ATOM 1045 C CE1 . TYR A 1 141 ? -4.331 -12.933 28.427 1.00 17.94 ? 167 TYR A CE1 1 ATOM 1046 C CE2 . TYR A 1 141 ? -4.094 -10.974 27.068 1.00 18.13 ? 167 TYR A CE2 1 ATOM 1047 C CZ . TYR A 1 141 ? -4.615 -11.606 28.186 1.00 18.11 ? 167 TYR A CZ 1 ATOM 1048 O OH . TYR A 1 141 ? -5.420 -10.909 29.057 1.00 18.03 ? 167 TYR A OH 1 ATOM 1049 N N . GLY A 1 142 ? 1.089 -14.902 24.745 1.00 17.45 ? 168 GLY A N 1 ATOM 1050 C CA . GLY A 1 142 ? 1.923 -15.478 23.679 1.00 17.03 ? 168 GLY A CA 1 ATOM 1051 C C . GLY A 1 142 ? 1.854 -14.657 22.402 1.00 17.02 ? 168 GLY A C 1 ATOM 1052 O O . GLY A 1 142 ? 0.815 -14.078 22.091 1.00 16.87 ? 168 GLY A O 1 ATOM 1053 N N . LEU A 1 143 ? 2.960 -14.625 21.657 1.00 16.91 ? 169 LEU A N 1 ATOM 1054 C CA . LEU A 1 143 ? 3.079 -13.816 20.438 1.00 17.13 ? 169 LEU A CA 1 ATOM 1055 C C . LEU A 1 143 ? 2.107 -14.255 19.347 1.00 17.47 ? 169 LEU A C 1 ATOM 1056 O O . LEU A 1 143 ? 1.557 -13.418 18.623 1.00 17.43 ? 169 LEU A O 1 ATOM 1057 C CB . LEU A 1 143 ? 4.514 -13.882 19.888 1.00 17.01 ? 169 LEU A CB 1 ATOM 1058 C CG . LEU A 1 143 ? 4.813 -13.112 18.594 1.00 16.92 ? 169 LEU A CG 1 ATOM 1059 C CD1 . LEU A 1 143 ? 4.464 -11.636 18.752 1.00 16.91 ? 169 LEU A CD1 1 ATOM 1060 C CD2 . LEU A 1 143 ? 6.272 -13.261 18.188 1.00 16.70 ? 169 LEU A CD2 1 ATOM 1061 N N . ALA A 1 144 ? 1.928 -15.570 19.220 1.00 17.64 ? 170 ALA A N 1 ATOM 1062 C CA . ALA A 1 144 ? 1.014 -16.146 18.246 1.00 17.84 ? 170 ALA A CA 1 ATOM 1063 C C . ALA A 1 144 ? -0.394 -15.584 18.415 1.00 17.94 ? 170 ALA A C 1 ATOM 1064 O O . ALA A 1 144 ? -1.065 -15.270 17.436 1.00 18.21 ? 170 ALA A O 1 ATOM 1065 C CB . ALA A 1 144 ? 0.987 -17.658 18.382 1.00 17.86 ? 170 ALA A CB 1 ATOM 1066 N N . HIS A 1 145 ? -0.836 -15.461 19.662 1.00 17.92 ? 171 HIS A N 1 ATOM 1067 C CA . HIS A 1 145 ? -2.181 -14.978 19.943 1.00 17.48 ? 171 HIS A CA 1 ATOM 1068 C C . HIS A 1 145 ? -2.303 -13.472 19.691 1.00 16.93 ? 171 HIS A C 1 ATOM 1069 O O . HIS A 1 145 ? -3.210 -13.029 18.993 1.00 16.67 ? 171 HIS A O 1 ATOM 1070 C CB . HIS A 1 145 ? -2.579 -15.309 21.377 1.00 17.62 ? 171 HIS A CB 1 ATOM 1071 C CG . HIS A 1 145 ? -3.964 -14.870 21.725 1.00 18.17 ? 171 HIS A CG 1 ATOM 1072 N ND1 . HIS A 1 145 ? -5.086 -15.506 21.240 1.00 18.25 ? 171 HIS A ND1 1 ATOM 1073 C CD2 . HIS A 1 145 ? -4.412 -13.845 22.489 1.00 18.05 ? 171 HIS A CD2 1 ATOM 1074 C CE1 . HIS A 1 145 ? -6.165 -14.898 21.699 1.00 18.46 ? 171 HIS A CE1 1 ATOM 1075 N NE2 . HIS A 1 145 ? -5.785 -13.889 22.461 1.00 18.34 ? 171 HIS A NE2 1 ATOM 1076 N N . VAL A 1 146 ? -1.376 -12.692 20.241 1.00 16.65 ? 172 VAL A N 1 ATOM 1077 C CA . VAL A 1 146 ? -1.435 -11.228 20.121 1.00 16.36 ? 172 VAL A CA 1 ATOM 1078 C C . VAL A 1 146 ? -1.215 -10.784 18.668 1.00 16.07 ? 172 VAL A C 1 ATOM 1079 O O . VAL A 1 146 ? -1.706 -9.725 18.257 1.00 15.43 ? 172 VAL A O 1 ATOM 1080 C CB . VAL A 1 146 ? -0.430 -10.533 21.072 1.00 16.43 ? 172 VAL A CB 1 ATOM 1081 C CG1 . VAL A 1 146 ? -0.534 -9.018 20.968 1.00 16.53 ? 172 VAL A CG1 1 ATOM 1082 C CG2 . VAL A 1 146 ? -0.671 -10.967 22.510 1.00 16.43 ? 172 VAL A CG2 1 ATOM 1083 N N . SER A 1 147 ? -0.502 -11.601 17.891 1.00 15.90 ? 173 SER A N 1 ATOM 1084 C CA . SER A 1 147 ? -0.317 -11.345 16.452 1.00 16.26 ? 173 SER A CA 1 ATOM 1085 C C . SER A 1 147 ? -1.616 -11.383 15.649 1.00 16.05 ? 173 SER A C 1 ATOM 1086 O O . SER A 1 147 ? -1.658 -10.864 14.539 1.00 15.66 ? 173 SER A O 1 ATOM 1087 C CB . SER A 1 147 ? 0.666 -12.342 15.835 1.00 16.53 ? 173 SER A CB 1 ATOM 1088 O OG . SER A 1 147 ? 1.977 -12.100 16.307 1.00 17.48 ? 173 SER A OG 1 ATOM 1089 N N . LYS A 1 148 ? -2.656 -12.009 16.199 1.00 16.02 ? 174 LYS A N 1 ATOM 1090 C CA . LYS A 1 148 ? -3.982 -12.006 15.574 1.00 16.06 ? 174 LYS A CA 1 ATOM 1091 C C . LYS A 1 148 ? -4.762 -10.719 15.822 1.00 15.37 ? 174 LYS A C 1 ATOM 1092 O O . LYS A 1 148 ? -5.709 -10.431 15.097 1.00 15.38 ? 174 LYS A O 1 ATOM 1093 C CB . LYS A 1 148 ? -4.818 -13.184 16.077 1.00 16.47 ? 174 LYS A CB 1 ATOM 1094 C CG . LYS A 1 148 ? -4.216 -14.542 15.784 1.00 16.98 ? 174 LYS A CG 1 ATOM 1095 C CD . LYS A 1 148 ? -5.097 -15.650 16.345 1.00 17.74 ? 174 LYS A CD 1 ATOM 1096 C CE . LYS A 1 148 ? -4.435 -17.008 16.189 1.00 18.12 ? 174 LYS A CE 1 ATOM 1097 N NZ . LYS A 1 148 ? -5.163 -18.042 16.975 1.00 18.68 ? 174 LYS A NZ 1 ATOM 1098 N N . TRP A 1 149 ? -4.376 -9.952 16.839 1.00 14.73 ? 175 TRP A N 1 ATOM 1099 C CA . TRP A 1 149 ? -5.154 -8.778 17.246 1.00 14.33 ? 175 TRP A CA 1 ATOM 1100 C C . TRP A 1 149 ? -5.106 -7.674 16.209 1.00 14.16 ? 175 TRP A C 1 ATOM 1101 O O . TRP A 1 149 ? -4.043 -7.339 15.688 1.00 14.35 ? 175 TRP A O 1 ATOM 1102 C CB . TRP A 1 149 ? -4.655 -8.213 18.574 1.00 14.06 ? 175 TRP A CB 1 ATOM 1103 C CG . TRP A 1 149 ? -4.881 -9.101 19.749 1.00 13.89 ? 175 TRP A CG 1 ATOM 1104 C CD1 . TRP A 1 149 ? -5.361 -10.381 19.739 1.00 13.77 ? 175 TRP A CD1 1 ATOM 1105 C CD2 . TRP A 1 149 ? -4.593 -8.792 21.114 1.00 13.65 ? 175 TRP A CD2 1 ATOM 1106 N NE1 . TRP A 1 149 ? -5.398 -10.879 21.014 1.00 13.65 ? 175 TRP A NE1 1 ATOM 1107 C CE2 . TRP A 1 149 ? -4.929 -9.926 21.878 1.00 13.58 ? 175 TRP A CE2 1 ATOM 1108 C CE3 . TRP A 1 149 ? -4.078 -7.666 21.765 1.00 13.67 ? 175 TRP A CE3 1 ATOM 1109 C CZ2 . TRP A 1 149 ? -4.782 -9.965 23.262 1.00 13.61 ? 175 TRP A CZ2 1 ATOM 1110 C CZ3 . TRP A 1 149 ? -3.932 -7.705 23.146 1.00 13.68 ? 175 TRP A CZ3 1 ATOM 1111 C CH2 . TRP A 1 149 ? -4.282 -8.849 23.877 1.00 13.61 ? 175 TRP A CH2 1 ATOM 1112 N N . ASN A 1 150 ? -6.269 -7.107 15.916 1.00 13.76 ? 176 ASN A N 1 ATOM 1113 C CA . ASN A 1 150 ? -6.340 -5.936 15.071 1.00 13.50 ? 176 ASN A CA 1 ATOM 1114 C C . ASN A 1 150 ? -6.162 -4.694 15.928 1.00 13.54 ? 176 ASN A C 1 ATOM 1115 O O . ASN A 1 150 ? -7.142 -4.132 16.430 1.00 13.50 ? 176 ASN A O 1 ATOM 1116 C CB . ASN A 1 150 ? -7.679 -5.877 14.343 1.00 13.28 ? 176 ASN A CB 1 ATOM 1117 C CG . ASN A 1 150 ? -7.819 -6.957 13.289 1.00 13.17 ? 176 ASN A CG 1 ATOM 1118 O OD1 . ASN A 1 150 ? -6.935 -7.140 12.450 1.00 13.23 ? 176 ASN A OD1 1 ATOM 1119 N ND2 . ASN A 1 150 ? -8.944 -7.660 13.308 1.00 12.95 ? 176 ASN A ND2 1 ATOM 1120 N N . PHE A 1 151 ? -4.913 -4.278 16.112 1.00 13.50 ? 177 PHE A N 1 ATOM 1121 C CA . PHE A 1 151 ? -4.642 -2.994 16.751 1.00 13.56 ? 177 PHE A CA 1 ATOM 1122 C C . PHE A 1 151 ? -5.120 -1.891 15.822 1.00 13.52 ? 177 PHE A C 1 ATOM 1123 O O . PHE A 1 151 ? -4.964 -1.976 14.603 1.00 13.18 ? 177 PHE A O 1 ATOM 1124 C CB . PHE A 1 151 ? -3.158 -2.811 17.072 1.00 13.63 ? 177 PHE A CB 1 ATOM 1125 C CG . PHE A 1 151 ? -2.671 -3.674 18.201 1.00 13.67 ? 177 PHE A CG 1 ATOM 1126 C CD1 . PHE A 1 151 ? -2.779 -3.241 19.515 1.00 13.71 ? 177 PHE A CD1 1 ATOM 1127 C CD2 . PHE A 1 151 ? -2.100 -4.906 17.953 1.00 13.72 ? 177 PHE A CD2 1 ATOM 1128 C CE1 . PHE A 1 151 ? -2.330 -4.026 20.557 1.00 13.75 ? 177 PHE A CE1 1 ATOM 1129 C CE2 . PHE A 1 151 ? -1.649 -5.699 18.990 1.00 13.77 ? 177 PHE A CE2 1 ATOM 1130 C CZ . PHE A 1 151 ? -1.764 -5.258 20.294 1.00 13.80 ? 177 PHE A CZ 1 ATOM 1131 N N . GLU A 1 152 ? -5.706 -0.854 16.400 1.00 13.63 ? 178 GLU A N 1 ATOM 1132 C CA . GLU A 1 152 ? -6.352 0.169 15.599 1.00 13.91 ? 178 GLU A CA 1 ATOM 1133 C C . GLU A 1 152 ? -6.133 1.546 16.200 1.00 13.97 ? 178 GLU A C 1 ATOM 1134 O O . GLU A 1 152 ? -5.886 1.685 17.393 1.00 13.69 ? 178 GLU A O 1 ATOM 1135 C CB . GLU A 1 152 ? -7.850 -0.135 15.481 1.00 13.83 ? 178 GLU A CB 1 ATOM 1136 C CG . GLU A 1 152 ? -8.574 0.681 14.421 1.00 13.96 ? 178 GLU A CG 1 ATOM 1137 C CD . GLU A 1 152 ? -10.000 0.211 14.177 1.00 14.04 ? 178 GLU A CD 1 ATOM 1138 O OE1 . GLU A 1 152 ? -10.596 0.608 13.147 1.00 14.40 ? 178 GLU A OE1 1 ATOM 1139 O OE2 . GLU A 1 152 ? -10.529 -0.560 15.004 1.00 13.74 ? 178 GLU A OE2 1 ATOM 1140 N N . THR A 1 153 ? -6.217 2.562 15.353 1.00 14.23 ? 179 THR A N 1 ATOM 1141 C CA . THR A 1 153 ? -6.112 3.934 15.805 1.00 14.43 ? 179 THR A CA 1 ATOM 1142 C C . THR A 1 153 ? -7.344 4.327 16.601 1.00 14.62 ? 179 THR A C 1 ATOM 1143 O O . THR A 1 153 ? -8.379 3.650 16.567 1.00 14.42 ? 179 THR A O 1 ATOM 1144 C CB . THR A 1 153 ? -6.024 4.913 14.623 1.00 14.25 ? 179 THR A CB 1 ATOM 1145 O OG1 . THR A 1 153 ? -7.160 4.729 13.774 1.00 14.23 ? 179 THR A OG1 1 ATOM 1146 C CG2 . THR A 1 153 ? -4.767 4.691 13.832 1.00 14.36 ? 179 THR A CG2 1 ATOM 1147 N N . TRP A 1 154 ? -7.211 5.453 17.290 1.00 15.03 ? 180 TRP A N 1 ATOM 1148 C CA . TRP A 1 154 ? -8.317 6.130 17.962 1.00 15.24 ? 180 TRP A CA 1 ATOM 1149 C C . TRP A 1 154 ? -9.557 6.139 17.066 1.00 15.36 ? 180 TRP A C 1 ATOM 1150 O O . TRP A 1 154 ? -9.465 6.431 15.878 1.00 15.29 ? 180 TRP A O 1 ATOM 1151 C CB . TRP A 1 154 ? -7.887 7.567 18.289 1.00 15.01 ? 180 TRP A CB 1 ATOM 1152 C CG . TRP A 1 154 ? -8.594 8.203 19.433 1.00 15.01 ? 180 TRP A CG 1 ATOM 1153 C CD1 . TRP A 1 154 ? -9.917 8.534 19.504 1.00 14.95 ? 180 TRP A CD1 1 ATOM 1154 C CD2 . TRP A 1 154 ? -8.005 8.630 20.671 1.00 14.84 ? 180 TRP A CD2 1 ATOM 1155 N NE1 . TRP A 1 154 ? -10.189 9.126 20.716 1.00 14.89 ? 180 TRP A NE1 1 ATOM 1156 C CE2 . TRP A 1 154 ? -9.033 9.195 21.449 1.00 14.70 ? 180 TRP A CE2 1 ATOM 1157 C CE3 . TRP A 1 154 ? -6.708 8.575 21.200 1.00 14.79 ? 180 TRP A CE3 1 ATOM 1158 C CZ2 . TRP A 1 154 ? -8.806 9.715 22.726 1.00 14.82 ? 180 TRP A CZ2 1 ATOM 1159 C CZ3 . TRP A 1 154 ? -6.481 9.093 22.463 1.00 14.83 ? 180 TRP A CZ3 1 ATOM 1160 C CH2 . TRP A 1 154 ? -7.531 9.654 23.217 1.00 14.74 ? 180 TRP A CH2 1 ATOM 1161 N N . ASN A 1 155 ? -10.710 5.817 17.640 1.00 15.91 ? 181 ASN A N 1 ATOM 1162 C CA . ASN A 1 155 ? -11.959 5.752 16.886 1.00 16.81 ? 181 ASN A CA 1 ATOM 1163 C C . ASN A 1 155 ? -12.412 7.095 16.314 1.00 17.40 ? 181 ASN A C 1 ATOM 1164 O O . ASN A 1 155 ? -12.335 8.118 16.992 1.00 16.90 ? 181 ASN A O 1 ATOM 1165 C CB . ASN A 1 155 ? -13.074 5.205 17.770 1.00 17.06 ? 181 ASN A CB 1 ATOM 1166 C CG . ASN A 1 155 ? -14.372 5.039 17.017 1.00 17.30 ? 181 ASN A CG 1 ATOM 1167 O OD1 . ASN A 1 155 ? -14.490 4.182 16.136 1.00 17.27 ? 181 ASN A OD1 1 ATOM 1168 N ND2 . ASN A 1 155 ? -15.356 5.868 17.348 1.00 17.62 ? 181 ASN A ND2 1 ATOM 1169 N N . GLU A 1 156 ? -12.887 7.069 15.066 1.00 18.45 ? 182 GLU A N 1 ATOM 1170 C CA . GLU A 1 156 ? -13.479 8.234 14.403 1.00 19.02 ? 182 GLU A CA 1 ATOM 1171 C C . GLU A 1 156 ? -12.736 9.543 14.690 1.00 18.90 ? 182 GLU A C 1 ATOM 1172 O O . GLU A 1 156 ? -13.278 10.441 15.330 1.00 18.60 ? 182 GLU A O 1 ATOM 1173 C CB . GLU A 1 156 ? -14.957 8.363 14.789 1.00 19.73 ? 182 GLU A CB 1 ATOM 1174 C CG . GLU A 1 156 ? -15.808 7.208 14.285 1.00 20.51 ? 182 GLU A CG 1 ATOM 1175 C CD . GLU A 1 156 ? -17.282 7.370 14.600 1.00 21.24 ? 182 GLU A CD 1 ATOM 1176 O OE1 . GLU A 1 156 ? -17.649 8.260 15.399 1.00 22.26 ? 182 GLU A OE1 1 ATOM 1177 O OE2 . GLU A 1 156 ? -18.080 6.587 14.051 1.00 22.27 ? 182 GLU A OE2 1 ATOM 1178 N N . PRO A 1 157 ? -11.490 9.656 14.208 1.00 19.38 ? 183 PRO A N 1 ATOM 1179 C CA . PRO A 1 157 ? -10.688 10.856 14.462 1.00 19.91 ? 183 PRO A CA 1 ATOM 1180 C C . PRO A 1 157 ? -11.311 12.154 13.949 1.00 20.72 ? 183 PRO A C 1 ATOM 1181 O O . PRO A 1 157 ? -11.072 13.210 14.530 1.00 21.14 ? 183 PRO A O 1 ATOM 1182 C CB . PRO A 1 157 ? -9.365 10.565 13.737 1.00 19.75 ? 183 PRO A CB 1 ATOM 1183 C CG . PRO A 1 157 ? -9.653 9.439 12.806 1.00 19.69 ? 183 PRO A CG 1 ATOM 1184 C CD . PRO A 1 157 ? -10.737 8.639 13.455 1.00 19.31 ? 183 PRO A CD 1 ATOM 1185 N N . ASP A 1 158 ? -12.112 12.078 12.888 1.00 21.41 ? 184 ASP A N 1 ATOM 1186 C CA . ASP A 1 158 ? -12.762 13.272 12.336 1.00 22.22 ? 184 ASP A CA 1 ATOM 1187 C C . ASP A 1 158 ? -14.103 13.629 13.007 1.00 23.93 ? 184 ASP A C 1 ATOM 1188 O O . ASP A 1 158 ? -14.772 14.577 12.589 1.00 23.12 ? 184 ASP A O 1 ATOM 1189 C CB . ASP A 1 158 ? -12.928 13.130 10.817 1.00 21.39 ? 184 ASP A CB 1 ATOM 1190 C CG . ASP A 1 158 ? -11.593 13.123 10.086 1.00 21.23 ? 184 ASP A CG 1 ATOM 1191 O OD1 . ASP A 1 158 ? -10.839 14.115 10.214 1.00 20.54 ? 184 ASP A OD1 1 ATOM 1192 O OD2 . ASP A 1 158 ? -11.297 12.131 9.378 1.00 20.56 ? 184 ASP A OD2 1 ATOM 1193 N N . HIS A 1 159 ? -14.481 12.887 14.048 1.00 26.31 ? 185 HIS A N 1 ATOM 1194 C CA . HIS A 1 159 ? -15.665 13.214 14.850 1.00 28.91 ? 185 HIS A CA 1 ATOM 1195 C C . HIS A 1 159 ? -15.329 13.912 16.178 1.00 31.31 ? 185 HIS A C 1 ATOM 1196 O O . HIS A 1 159 ? -16.200 14.058 17.034 1.00 31.54 ? 185 HIS A O 1 ATOM 1197 C CB . HIS A 1 159 ? -16.495 11.952 15.103 1.00 29.35 ? 185 HIS A CB 1 ATOM 1198 C CG . HIS A 1 159 ? -17.320 11.532 13.927 1.00 29.87 ? 185 HIS A CG 1 ATOM 1199 N ND1 . HIS A 1 159 ? -16.764 11.085 12.747 1.00 30.63 ? 185 HIS A ND1 1 ATOM 1200 C CD2 . HIS A 1 159 ? -18.662 11.495 13.748 1.00 30.44 ? 185 HIS A CD2 1 ATOM 1201 C CE1 . HIS A 1 159 ? -17.728 10.790 11.892 1.00 30.52 ? 185 HIS A CE1 1 ATOM 1202 N NE2 . HIS A 1 159 ? -18.889 11.031 12.475 1.00 30.52 ? 185 HIS A NE2 1 ATOM 1203 N N . HIS A 1 160 ? -14.073 14.332 16.344 1.00 34.38 ? 186 HIS A N 1 ATOM 1204 C CA . HIS A 1 160 ? -13.653 15.215 17.450 1.00 37.60 ? 186 HIS A CA 1 ATOM 1205 C C . HIS A 1 160 ? -13.972 14.673 18.848 1.00 38.61 ? 186 HIS A C 1 ATOM 1206 O O . HIS A 1 160 ? -14.371 15.431 19.734 1.00 39.31 ? 186 HIS A O 1 ATOM 1207 C CB . HIS A 1 160 ? -14.283 16.616 17.294 1.00 39.05 ? 186 HIS A CB 1 ATOM 1208 C CG . HIS A 1 160 ? -13.926 17.311 16.014 1.00 40.55 ? 186 HIS A CG 1 ATOM 1209 N ND1 . HIS A 1 160 ? -14.641 17.138 14.846 1.00 41.38 ? 186 HIS A ND1 1 ATOM 1210 C CD2 . HIS A 1 160 ? -12.945 18.199 15.725 1.00 41.70 ? 186 HIS A CD2 1 ATOM 1211 C CE1 . HIS A 1 160 ? -14.107 17.878 13.890 1.00 41.50 ? 186 HIS A CE1 1 ATOM 1212 N NE2 . HIS A 1 160 ? -13.076 18.531 14.397 1.00 42.50 ? 186 HIS A NE2 1 ATOM 1213 N N . ASP A 1 161 ? -13.795 13.369 19.045 1.00 40.10 ? 187 ASP A N 1 ATOM 1214 C CA . ASP A 1 161 ? -14.089 12.737 20.336 1.00 41.13 ? 187 ASP A CA 1 ATOM 1215 C C . ASP A 1 161 ? -12.806 12.270 21.030 1.00 40.56 ? 187 ASP A C 1 ATOM 1216 O O . ASP A 1 161 ? -12.516 11.069 21.101 1.00 38.67 ? 187 ASP A O 1 ATOM 1217 C CB . ASP A 1 161 ? -15.065 11.567 20.148 1.00 42.69 ? 187 ASP A CB 1 ATOM 1218 C CG . ASP A 1 161 ? -15.596 11.023 21.469 1.00 43.71 ? 187 ASP A CG 1 ATOM 1219 O OD1 . ASP A 1 161 ? -15.604 11.766 22.476 1.00 42.79 ? 187 ASP A OD1 1 ATOM 1220 O OD2 . ASP A 1 161 ? -16.012 9.846 21.493 1.00 46.59 ? 187 ASP A OD2 1 ATOM 1221 N N . PHE A 1 162 ? -12.051 13.240 21.542 1.00 40.62 ? 188 PHE A N 1 ATOM 1222 C CA . PHE A 1 162 ? -10.802 12.983 22.260 1.00 41.47 ? 188 PHE A CA 1 ATOM 1223 C C . PHE A 1 162 ? -10.871 13.477 23.709 1.00 41.96 ? 188 PHE A C 1 ATOM 1224 O O . PHE A 1 162 ? -9.851 13.516 24.403 1.00 42.38 ? 188 PHE A O 1 ATOM 1225 C CB . PHE A 1 162 ? -9.641 13.684 21.545 1.00 40.66 ? 188 PHE A CB 1 ATOM 1226 C CG . PHE A 1 162 ? -9.556 13.376 20.080 1.00 40.12 ? 188 PHE A CG 1 ATOM 1227 C CD1 . PHE A 1 162 ? -8.948 12.207 19.639 1.00 39.88 ? 188 PHE A CD1 1 ATOM 1228 C CD2 . PHE A 1 162 ? -10.079 14.252 19.138 1.00 39.79 ? 188 PHE A CD2 1 ATOM 1229 C CE1 . PHE A 1 162 ? -8.864 11.917 18.288 1.00 39.42 ? 188 PHE A CE1 1 ATOM 1230 C CE2 . PHE A 1 162 ? -10.000 13.966 17.784 1.00 39.29 ? 188 PHE A CE2 1 ATOM 1231 C CZ . PHE A 1 162 ? -9.391 12.798 17.360 1.00 39.37 ? 188 PHE A CZ 1 ATOM 1232 N N . ASP A 1 163 ? -12.087 13.780 24.170 1.00 42.09 ? 189 ASP A N 1 ATOM 1233 C CA . ASP A 1 163 ? -12.339 14.684 25.312 1.00 42.36 ? 189 ASP A CA 1 ATOM 1234 C C . ASP A 1 163 ? -11.200 15.676 25.632 1.00 40.49 ? 189 ASP A C 1 ATOM 1235 O O . ASP A 1 163 ? -11.119 16.723 24.992 1.00 38.67 ? 189 ASP A O 1 ATOM 1236 C CB . ASP A 1 163 ? -12.879 13.951 26.569 1.00 44.37 ? 189 ASP A CB 1 ATOM 1237 C CG . ASP A 1 163 ? -12.226 12.597 26.824 1.00 45.90 ? 189 ASP A CG 1 ATOM 1238 O OD1 . ASP A 1 163 ? -11.790 11.924 25.870 1.00 47.14 ? 189 ASP A OD1 1 ATOM 1239 O OD2 . ASP A 1 163 ? -12.183 12.191 28.006 1.00 46.93 ? 189 ASP A OD2 1 ATOM 1240 N N . ASN A 1 164 ? -10.327 15.358 26.590 1.00 39.03 ? 190 ASN A N 1 ATOM 1241 C CA . ASN A 1 164 ? -9.301 16.317 27.045 1.00 37.59 ? 190 ASN A CA 1 ATOM 1242 C C . ASN A 1 164 ? -7.990 16.319 26.241 1.00 34.69 ? 190 ASN A C 1 ATOM 1243 O O . ASN A 1 164 ? -7.098 17.119 26.519 1.00 34.04 ? 190 ASN A O 1 ATOM 1244 C CB . ASN A 1 164 ? -8.986 16.106 28.538 1.00 38.84 ? 190 ASN A CB 1 ATOM 1245 C CG . ASN A 1 164 ? -9.465 17.254 29.409 1.00 40.24 ? 190 ASN A CG 1 ATOM 1246 O OD1 . ASN A 1 164 ? -10.183 17.044 30.388 1.00 42.22 ? 190 ASN A OD1 1 ATOM 1247 N ND2 . ASN A 1 164 ? -9.061 18.477 29.064 1.00 40.64 ? 190 ASN A ND2 1 ATOM 1248 N N . VAL A 1 165 ? -7.871 15.437 25.253 1.00 31.66 ? 191 VAL A N 1 ATOM 1249 C CA . VAL A 1 165 ? -6.652 15.349 24.450 1.00 29.64 ? 191 VAL A CA 1 ATOM 1250 C C . VAL A 1 165 ? -6.714 16.318 23.271 1.00 27.71 ? 191 VAL A C 1 ATOM 1251 O O . VAL A 1 165 ? -7.737 16.420 22.588 1.00 27.38 ? 191 VAL A O 1 ATOM 1252 C CB . VAL A 1 165 ? -6.434 13.916 23.917 1.00 29.84 ? 191 VAL A CB 1 ATOM 1253 C CG1 . VAL A 1 165 ? -5.168 13.833 23.074 1.00 29.99 ? 191 VAL A CG1 1 ATOM 1254 C CG2 . VAL A 1 165 ? -6.372 12.925 25.069 1.00 29.92 ? 191 VAL A CG2 1 ATOM 1255 N N . SER A 1 166 ? -5.617 17.033 23.042 1.00 25.72 ? 192 SER A N 1 ATOM 1256 C CA . SER A 1 166 ? -5.475 17.859 21.849 1.00 24.71 ? 192 SER A CA 1 ATOM 1257 C C . SER A 1 166 ? -4.915 16.998 20.717 1.00 23.88 ? 192 SER A C 1 ATOM 1258 O O . SER A 1 166 ? -3.768 16.542 20.782 1.00 22.99 ? 192 SER A O 1 ATOM 1259 C CB . SER A 1 166 ? -4.554 19.052 22.112 1.00 24.46 ? 192 SER A CB 1 ATOM 1260 O OG . SER A 1 166 ? -4.211 19.703 20.898 1.00 24.34 ? 192 SER A OG 1 ATOM 1261 N N . MET A 1 167 ? -5.738 16.771 19.695 1.00 22.81 ? 193 MET A N 1 ATOM 1262 C CA . MET A 1 167 ? -5.343 15.984 18.531 1.00 22.05 ? 193 MET A CA 1 ATOM 1263 C C . MET A 1 167 ? -5.579 16.776 17.248 1.00 21.06 ? 193 MET A C 1 ATOM 1264 O O . MET A 1 167 ? -6.643 16.705 16.650 1.00 20.95 ? 193 MET A O 1 ATOM 1265 C CB . MET A 1 167 ? -6.113 14.658 18.491 1.00 21.95 ? 193 MET A CB 1 ATOM 1266 C CG . MET A 1 167 ? -5.586 13.671 17.463 1.00 22.06 ? 193 MET A CG 1 ATOM 1267 S SD . MET A 1 167 ? -4.149 12.741 18.032 1.00 22.42 ? 193 MET A SD 1 ATOM 1268 C CE . MET A 1 167 ? -4.971 11.417 18.916 1.00 22.36 ? 193 MET A CE 1 ATOM 1269 N N . THR A 1 168 ? -4.565 17.526 16.837 1.00 20.47 ? 194 THR A N 1 ATOM 1270 C CA . THR A 1 168 ? -4.573 18.215 15.555 1.00 19.98 ? 194 THR A CA 1 ATOM 1271 C C . THR A 1 168 ? -4.264 17.223 14.433 1.00 19.95 ? 194 THR A C 1 ATOM 1272 O O . THR A 1 168 ? -3.961 16.051 14.692 1.00 19.59 ? 194 THR A O 1 ATOM 1273 C CB . THR A 1 168 ? -3.506 19.329 15.519 1.00 19.82 ? 194 THR A CB 1 ATOM 1274 O OG1 . THR A 1 168 ? -2.205 18.750 15.686 1.00 19.09 ? 194 THR A OG1 1 ATOM 1275 C CG2 . THR A 1 168 ? -3.760 20.366 16.621 1.00 19.86 ? 194 THR A CG2 1 ATOM 1276 N N . MET A 1 169 ? -4.334 17.700 13.192 1.00 19.73 ? 195 MET A N 1 ATOM 1277 C CA . MET A 1 169 ? -3.930 16.908 12.035 1.00 20.12 ? 195 MET A CA 1 ATOM 1278 C C . MET A 1 169 ? -2.521 16.358 12.256 1.00 19.39 ? 195 MET A C 1 ATOM 1279 O O . MET A 1 169 ? -2.304 15.148 12.176 1.00 19.14 ? 195 MET A O 1 ATOM 1280 C CB . MET A 1 169 ? -3.985 17.758 10.754 1.00 20.75 ? 195 MET A CB 1 ATOM 1281 C CG . MET A 1 169 ? -3.425 17.105 9.494 1.00 21.23 ? 195 MET A CG 1 ATOM 1282 S SD . MET A 1 169 ? -4.510 15.835 8.817 1.00 22.51 ? 195 MET A SD 1 ATOM 1283 C CE . MET A 1 169 ? -3.884 14.363 9.616 1.00 22.54 ? 195 MET A CE 1 ATOM 1284 N N . GLN A 1 170 ? -1.577 17.247 12.549 1.00 18.58 ? 196 GLN A N 1 ATOM 1285 C CA . GLN A 1 170 ? -0.194 16.839 12.797 1.00 18.13 ? 196 GLN A CA 1 ATOM 1286 C C . GLN A 1 170 ? -0.079 15.940 14.026 1.00 17.34 ? 196 GLN A C 1 ATOM 1287 O O . GLN A 1 170 ? 0.697 14.986 14.031 1.00 17.17 ? 196 GLN A O 1 ATOM 1288 C CB . GLN A 1 170 ? 0.711 18.058 12.984 1.00 18.19 ? 196 GLN A CB 1 ATOM 1289 C CG . GLN A 1 170 ? 2.190 17.714 13.079 1.00 18.29 ? 196 GLN A CG 1 ATOM 1290 C CD . GLN A 1 170 ? 2.676 16.974 11.850 1.00 18.63 ? 196 GLN A CD 1 ATOM 1291 O OE1 . GLN A 1 170 ? 2.478 17.435 10.730 1.00 19.35 ? 196 GLN A OE1 1 ATOM 1292 N NE2 . GLN A 1 170 ? 3.287 15.813 12.048 1.00 18.91 ? 196 GLN A NE2 1 ATOM 1293 N N . GLY A 1 171 ? -0.839 16.258 15.069 1.00 16.53 ? 197 GLY A N 1 ATOM 1294 C CA . GLY A 1 171 ? -0.864 15.432 16.272 1.00 15.98 ? 197 GLY A CA 1 ATOM 1295 C C . GLY A 1 171 ? -1.272 13.997 15.991 1.00 15.28 ? 197 GLY A C 1 ATOM 1296 O O . GLY A 1 171 ? -0.686 13.063 16.535 1.00 14.91 ? 197 GLY A O 1 ATOM 1297 N N . PHE A 1 172 ? -2.282 13.832 15.137 1.00 14.79 ? 198 PHE A N 1 ATOM 1298 C CA . PHE A 1 172 ? -2.794 12.514 14.777 1.00 14.46 ? 198 PHE A CA 1 ATOM 1299 C C . PHE A 1 172 ? -1.709 11.704 14.084 1.00 14.26 ? 198 PHE A C 1 ATOM 1300 O O . PHE A 1 172 ? -1.471 10.545 14.428 1.00 14.05 ? 198 PHE A O 1 ATOM 1301 C CB . PHE A 1 172 ? -4.038 12.639 13.884 1.00 14.44 ? 198 PHE A CB 1 ATOM 1302 C CG . PHE A 1 172 ? -4.752 11.330 13.639 1.00 14.44 ? 198 PHE A CG 1 ATOM 1303 C CD1 . PHE A 1 172 ? -5.214 10.564 14.702 1.00 14.33 ? 198 PHE A CD1 1 ATOM 1304 C CD2 . PHE A 1 172 ? -4.976 10.872 12.348 1.00 14.49 ? 198 PHE A CD2 1 ATOM 1305 C CE1 . PHE A 1 172 ? -5.874 9.367 14.481 1.00 14.39 ? 198 PHE A CE1 1 ATOM 1306 C CE2 . PHE A 1 172 ? -5.634 9.672 12.122 1.00 14.35 ? 198 PHE A CE2 1 ATOM 1307 C CZ . PHE A 1 172 ? -6.082 8.919 13.190 1.00 14.36 ? 198 PHE A CZ 1 ATOM 1308 N N . LEU A 1 173 ? -1.018 12.333 13.142 1.00 14.00 ? 199 LEU A N 1 ATOM 1309 C CA . LEU A 1 173 ? 0.074 11.670 12.435 1.00 13.83 ? 199 LEU A CA 1 ATOM 1310 C C . LEU A 1 173 ? 1.197 11.251 13.394 1.00 13.58 ? 199 LEU A C 1 ATOM 1311 O O . LEU A 1 173 ? 1.732 10.144 13.283 1.00 13.53 ? 199 LEU A O 1 ATOM 1312 C CB . LEU A 1 173 ? 0.614 12.571 11.321 1.00 13.90 ? 199 LEU A CB 1 ATOM 1313 C CG . LEU A 1 173 ? -0.401 13.080 10.292 1.00 14.05 ? 199 LEU A CG 1 ATOM 1314 C CD1 . LEU A 1 173 ? 0.307 13.802 9.146 1.00 14.13 ? 199 LEU A CD1 1 ATOM 1315 C CD2 . LEU A 1 173 ? -1.269 11.944 9.762 1.00 13.97 ? 199 LEU A CD2 1 ATOM 1316 N N . ASN A 1 174 ? 1.540 12.132 14.334 1.00 13.36 ? 200 ASN A N 1 ATOM 1317 C CA . ASN A 1 174 ? 2.536 11.826 15.368 1.00 13.17 ? 200 ASN A CA 1 ATOM 1318 C C . ASN A 1 174 ? 2.091 10.631 16.208 1.00 12.81 ? 200 ASN A C 1 ATOM 1319 O O . ASN A 1 174 ? 2.850 9.688 16.435 1.00 12.66 ? 200 ASN A O 1 ATOM 1320 C CB . ASN A 1 174 ? 2.749 13.024 16.298 1.00 13.15 ? 200 ASN A CB 1 ATOM 1321 C CG . ASN A 1 174 ? 3.347 14.226 15.594 1.00 13.41 ? 200 ASN A CG 1 ATOM 1322 O OD1 . ASN A 1 174 ? 3.792 14.143 14.451 1.00 13.40 ? 200 ASN A OD1 1 ATOM 1323 N ND2 . ASN A 1 174 ? 3.356 15.363 16.285 1.00 13.56 ? 200 ASN A ND2 1 ATOM 1324 N N . TYR A 1 175 ? 0.850 10.713 16.677 1.00 12.54 ? 201 TYR A N 1 ATOM 1325 C CA . TYR A 1 175 ? 0.200 9.636 17.409 1.00 12.19 ? 201 TYR A CA 1 ATOM 1326 C C . TYR A 1 175 ? 0.240 8.312 16.643 1.00 11.97 ? 201 TYR A C 1 ATOM 1327 O O . TYR A 1 175 ? 0.556 7.264 17.221 1.00 12.04 ? 201 TYR A O 1 ATOM 1328 C CB . TYR A 1 175 ? -1.247 10.036 17.740 1.00 12.23 ? 201 TYR A CB 1 ATOM 1329 C CG . TYR A 1 175 ? -2.191 8.875 17.919 1.00 12.21 ? 201 TYR A CG 1 ATOM 1330 C CD1 . TYR A 1 175 ? -2.254 8.180 19.126 1.00 12.24 ? 201 TYR A CD1 1 ATOM 1331 C CD2 . TYR A 1 175 ? -3.019 8.463 16.874 1.00 12.24 ? 201 TYR A CD2 1 ATOM 1332 C CE1 . TYR A 1 175 ? -3.121 7.110 19.290 1.00 12.24 ? 201 TYR A CE1 1 ATOM 1333 C CE2 . TYR A 1 175 ? -3.885 7.395 17.025 1.00 12.27 ? 201 TYR A CE2 1 ATOM 1334 C CZ . TYR A 1 175 ? -3.932 6.721 18.232 1.00 12.28 ? 201 TYR A CZ 1 ATOM 1335 O OH . TYR A 1 175 ? -4.796 5.662 18.379 1.00 12.33 ? 201 TYR A OH 1 ATOM 1336 N N . TYR A 1 176 ? -0.067 8.351 15.350 1.00 11.81 ? 202 TYR A N 1 ATOM 1337 C CA . TYR A 1 176 ? -0.059 7.130 14.556 1.00 11.75 ? 202 TYR A CA 1 ATOM 1338 C C . TYR A 1 176 ? 1.343 6.508 14.487 1.00 11.60 ? 202 TYR A C 1 ATOM 1339 O O . TYR A 1 176 ? 1.495 5.293 14.611 1.00 11.06 ? 202 TYR A O 1 ATOM 1340 C CB . TYR A 1 176 ? -0.585 7.359 13.141 1.00 11.85 ? 202 TYR A CB 1 ATOM 1341 C CG . TYR A 1 176 ? -0.599 6.064 12.363 1.00 12.02 ? 202 TYR A CG 1 ATOM 1342 C CD1 . TYR A 1 176 ? -1.664 5.181 12.475 1.00 12.09 ? 202 TYR A CD1 1 ATOM 1343 C CD2 . TYR A 1 176 ? 0.479 5.693 11.573 1.00 12.16 ? 202 TYR A CD2 1 ATOM 1344 C CE1 . TYR A 1 176 ? -1.678 3.983 11.791 1.00 12.10 ? 202 TYR A CE1 1 ATOM 1345 C CE2 . TYR A 1 176 ? 0.481 4.494 10.889 1.00 12.29 ? 202 TYR A CE2 1 ATOM 1346 C CZ . TYR A 1 176 ? -0.603 3.643 10.998 1.00 12.21 ? 202 TYR A CZ 1 ATOM 1347 O OH . TYR A 1 176 ? -0.606 2.447 10.320 1.00 12.33 ? 202 TYR A OH 1 ATOM 1348 N N . ASP A 1 177 ? 2.354 7.348 14.283 1.00 11.53 ? 203 ASP A N 1 ATOM 1349 C CA . ASP A 1 177 ? 3.738 6.882 14.202 1.00 11.63 ? 203 ASP A CA 1 ATOM 1350 C C . ASP A 1 177 ? 4.198 6.288 15.531 1.00 11.54 ? 203 ASP A C 1 ATOM 1351 O O . ASP A 1 177 ? 4.931 5.299 15.550 1.00 11.40 ? 203 ASP A O 1 ATOM 1352 C CB . ASP A 1 177 ? 4.672 8.022 13.772 1.00 11.74 ? 203 ASP A CB 1 ATOM 1353 C CG . ASP A 1 177 ? 4.380 8.518 12.372 1.00 11.80 ? 203 ASP A CG 1 ATOM 1354 O OD1 . ASP A 1 177 ? 3.645 7.818 11.641 1.00 11.67 ? 203 ASP A OD1 1 ATOM 1355 O OD2 . ASP A 1 177 ? 4.875 9.610 12.002 1.00 11.88 ? 203 ASP A OD2 1 ATOM 1356 N N . ALA A 1 178 ? 3.751 6.885 16.634 1.00 11.65 ? 204 ALA A N 1 ATOM 1357 C CA . ALA A 1 178 ? 4.014 6.334 17.967 1.00 11.76 ? 204 ALA A CA 1 ATOM 1358 C C . ALA A 1 178 ? 3.341 4.970 18.138 1.00 11.81 ? 204 ALA A C 1 ATOM 1359 O O . ALA A 1 178 ? 3.944 4.040 18.672 1.00 11.61 ? 204 ALA A O 1 ATOM 1360 C CB . ALA A 1 178 ? 3.554 7.299 19.047 1.00 11.78 ? 204 ALA A CB 1 ATOM 1361 N N . CYS A 1 179 ? 2.097 4.848 17.677 1.00 12.02 ? 205 CYS A N 1 ATOM 1362 C CA . CYS A 1 179 ? 1.410 3.558 17.687 1.00 12.14 ? 205 CYS A CA 1 ATOM 1363 C C . CYS A 1 179 ? 2.217 2.541 16.889 1.00 12.22 ? 205 CYS A C 1 ATOM 1364 O O . CYS A 1 179 ? 2.508 1.446 17.372 1.00 12.47 ? 205 CYS A O 1 ATOM 1365 C CB . CYS A 1 179 ? 0.007 3.669 17.086 1.00 12.23 ? 205 CYS A CB 1 ATOM 1366 S SG . CYS A 1 179 ? -1.177 4.606 18.071 1.00 12.63 ? 205 CYS A SG 1 ATOM 1367 N N . SER A 1 180 ? 2.586 2.924 15.670 1.00 12.21 ? 206 SER A N 1 ATOM 1368 C CA . SER A 1 180 ? 3.267 2.028 14.737 1.00 12.08 ? 206 SER A CA 1 ATOM 1369 C C . SER A 1 180 ? 4.635 1.595 15.264 1.00 12.22 ? 206 SER A C 1 ATOM 1370 O O . SER A 1 180 ? 4.969 0.408 15.243 1.00 11.80 ? 206 SER A O 1 ATOM 1371 C CB . SER A 1 180 ? 3.413 2.707 13.372 1.00 11.95 ? 206 SER A CB 1 ATOM 1372 O OG . SER A 1 180 ? 3.757 1.777 12.361 1.00 11.73 ? 206 SER A OG 1 ATOM 1373 N N . GLU A 1 181 ? 5.418 2.555 15.753 1.00 12.61 ? 207 GLU A N 1 ATOM 1374 C CA . GLU A 1 181 ? 6.757 2.253 16.279 1.00 12.70 ? 207 GLU A CA 1 ATOM 1375 C C . GLU A 1 181 ? 6.690 1.520 17.608 1.00 12.74 ? 207 GLU A C 1 ATOM 1376 O O . GLU A 1 181 ? 7.521 0.659 17.883 1.00 12.71 ? 207 GLU A O 1 ATOM 1377 C CB . GLU A 1 181 ? 7.587 3.529 16.416 1.00 12.88 ? 207 GLU A CB 1 ATOM 1378 C CG . GLU A 1 181 ? 7.947 4.166 15.080 1.00 12.96 ? 207 GLU A CG 1 ATOM 1379 C CD . GLU A 1 181 ? 8.792 3.253 14.211 1.00 12.95 ? 207 GLU A CD 1 ATOM 1380 O OE1 . GLU A 1 181 ? 9.698 2.597 14.748 1.00 13.15 ? 207 GLU A OE1 1 ATOM 1381 O OE2 . GLU A 1 181 ? 8.551 3.187 12.992 1.00 13.19 ? 207 GLU A OE2 1 ATOM 1382 N N . GLY A 1 182 ? 5.693 1.854 18.425 1.00 12.96 ? 208 GLY A N 1 ATOM 1383 C CA . GLY A 1 182 ? 5.461 1.152 19.686 1.00 13.18 ? 208 GLY A CA 1 ATOM 1384 C C . GLY A 1 182 ? 5.224 -0.331 19.469 1.00 13.41 ? 208 GLY A C 1 ATOM 1385 O O . GLY A 1 182 ? 5.922 -1.173 20.043 1.00 13.41 ? 208 GLY A O 1 ATOM 1386 N N . LEU A 1 183 ? 4.253 -0.653 18.619 1.00 13.73 ? 209 LEU A N 1 ATOM 1387 C CA . LEU A 1 183 ? 3.954 -2.048 18.286 1.00 13.93 ? 209 LEU A CA 1 ATOM 1388 C C . LEU A 1 183 ? 5.153 -2.728 17.621 1.00 14.46 ? 209 LEU A C 1 ATOM 1389 O O . LEU A 1 183 ? 5.507 -3.853 17.970 1.00 13.79 ? 209 LEU A O 1 ATOM 1390 C CB . LEU A 1 183 ? 2.720 -2.136 17.378 1.00 13.72 ? 209 LEU A CB 1 ATOM 1391 C CG . LEU A 1 183 ? 1.383 -1.717 18.001 1.00 13.64 ? 209 LEU A CG 1 ATOM 1392 C CD1 . LEU A 1 183 ? 0.286 -1.644 16.953 1.00 13.53 ? 209 LEU A CD1 1 ATOM 1393 C CD2 . LEU A 1 183 ? 0.973 -2.674 19.109 1.00 13.89 ? 209 LEU A CD2 1 ATOM 1394 N N . ARG A 1 184 ? 5.772 -2.032 16.669 1.00 15.63 ? 210 ARG A N 1 ATOM 1395 C CA . ARG A 1 184 ? 6.955 -2.543 15.963 1.00 16.84 ? 210 ARG A CA 1 ATOM 1396 C C . ARG A 1 184 ? 8.067 -2.973 16.928 1.00 16.50 ? 210 ARG A C 1 ATOM 1397 O O . ARG A 1 184 ? 8.636 -4.048 16.776 1.00 16.35 ? 210 ARG A O 1 ATOM 1398 C CB . ARG A 1 184 ? 7.481 -1.495 14.973 1.00 17.95 ? 210 ARG A CB 1 ATOM 1399 C CG . ARG A 1 184 ? 8.854 -1.795 14.385 1.00 19.60 ? 210 ARG A CG 1 ATOM 1400 C CD . ARG A 1 184 ? 9.179 -0.839 13.247 1.00 20.94 ? 210 ARG A CD 1 ATOM 1401 N NE . ARG A 1 184 ? 10.602 -0.834 12.933 1.00 22.55 ? 210 ARG A NE 1 ATOM 1402 C CZ . ARG A 1 184 ? 11.245 -1.776 12.240 1.00 24.06 ? 210 ARG A CZ 1 ATOM 1403 N NH1 . ARG A 1 184 ? 10.605 -2.845 11.760 1.00 24.40 ? 210 ARG A NH1 1 ATOM 1404 N NH2 . ARG A 1 184 ? 12.553 -1.648 12.029 1.00 24.78 ? 210 ARG A NH2 1 ATOM 1405 N N . ALA A 1 185 ? 8.358 -2.134 17.921 1.00 16.43 ? 211 ALA A N 1 ATOM 1406 C CA . ALA A 1 185 ? 9.382 -2.439 18.922 1.00 16.25 ? 211 ALA A CA 1 ATOM 1407 C C . ALA A 1 185 ? 9.039 -3.660 19.790 1.00 16.27 ? 211 ALA A C 1 ATOM 1408 O O . ALA A 1 185 ? 9.936 -4.336 20.284 1.00 16.00 ? 211 ALA A O 1 ATOM 1409 C CB . ALA A 1 185 ? 9.640 -1.223 19.797 1.00 16.10 ? 211 ALA A CB 1 ATOM 1410 N N . ALA A 1 186 ? 7.750 -3.929 19.992 1.00 16.36 ? 212 ALA A N 1 ATOM 1411 C CA . ALA A 1 186 ? 7.326 -5.136 20.701 1.00 16.18 ? 212 ALA A CA 1 ATOM 1412 C C . ALA A 1 186 ? 7.534 -6.345 19.800 1.00 16.06 ? 212 ALA A C 1 ATOM 1413 O O . ALA A 1 186 ? 8.172 -7.312 20.193 1.00 16.37 ? 212 ALA A O 1 ATOM 1414 C CB . ALA A 1 186 ? 5.873 -5.031 21.122 1.00 16.38 ? 212 ALA A CB 1 ATOM 1415 N N . SER A 1 187 ? 6.989 -6.283 18.590 1.00 15.85 ? 213 SER A N 1 ATOM 1416 C CA . SER A 1 187 ? 7.244 -7.297 17.570 1.00 15.61 ? 213 SER A CA 1 ATOM 1417 C C . SER A 1 187 ? 6.782 -6.824 16.190 1.00 15.57 ? 213 SER A C 1 ATOM 1418 O O . SER A 1 187 ? 5.668 -6.315 16.056 1.00 15.00 ? 213 SER A O 1 ATOM 1419 C CB . SER A 1 187 ? 6.535 -8.606 17.916 1.00 15.48 ? 213 SER A CB 1 ATOM 1420 O OG . SER A 1 187 ? 6.598 -9.498 16.819 1.00 15.36 ? 213 SER A OG 1 ATOM 1421 N N . PRO A 1 188 ? 7.628 -7.005 15.155 1.00 15.97 ? 214 PRO A N 1 ATOM 1422 C CA . PRO A 1 188 ? 7.213 -6.702 13.778 1.00 16.12 ? 214 PRO A CA 1 ATOM 1423 C C . PRO A 1 188 ? 5.936 -7.413 13.331 1.00 16.05 ? 214 PRO A C 1 ATOM 1424 O O . PRO A 1 188 ? 5.244 -6.920 12.438 1.00 16.40 ? 214 PRO A O 1 ATOM 1425 C CB . PRO A 1 188 ? 8.402 -7.185 12.943 1.00 16.24 ? 214 PRO A CB 1 ATOM 1426 C CG . PRO A 1 188 ? 9.573 -7.018 13.848 1.00 16.28 ? 214 PRO A CG 1 ATOM 1427 C CD . PRO A 1 188 ? 9.058 -7.365 15.220 1.00 16.10 ? 214 PRO A CD 1 ATOM 1428 N N . ALA A 1 189 ? 5.633 -8.553 13.946 1.00 15.96 ? 215 ALA A N 1 ATOM 1429 C CA . ALA A 1 189 ? 4.464 -9.356 13.580 1.00 15.94 ? 215 ALA A CA 1 ATOM 1430 C C . ALA A 1 189 ? 3.125 -8.710 13.931 1.00 15.82 ? 215 ALA A C 1 ATOM 1431 O O . ALA A 1 189 ? 2.095 -9.115 13.405 1.00 15.97 ? 215 ALA A O 1 ATOM 1432 C CB . ALA A 1 189 ? 4.557 -10.734 14.222 1.00 16.00 ? 215 ALA A CB 1 ATOM 1433 N N . LEU A 1 190 ? 3.126 -7.715 14.812 1.00 15.97 ? 216 LEU A N 1 ATOM 1434 C CA . LEU A 1 190 ? 1.879 -7.097 15.239 1.00 15.96 ? 216 LEU A CA 1 ATOM 1435 C C . LEU A 1 190 ? 1.275 -6.218 14.145 1.00 16.28 ? 216 LEU A C 1 ATOM 1436 O O . LEU A 1 190 ? 1.984 -5.568 13.381 1.00 16.26 ? 216 LEU A O 1 ATOM 1437 C CB . LEU A 1 190 ? 2.075 -6.295 16.522 1.00 15.92 ? 216 LEU A CB 1 ATOM 1438 C CG . LEU A 1 190 ? 2.629 -7.062 17.723 1.00 15.82 ? 216 LEU A CG 1 ATOM 1439 C CD1 . LEU A 1 190 ? 2.565 -6.177 18.954 1.00 15.85 ? 216 LEU A CD1 1 ATOM 1440 C CD2 . LEU A 1 190 ? 1.873 -8.364 17.962 1.00 15.92 ? 216 LEU A CD2 1 ATOM 1441 N N . ARG A 1 191 ? -0.051 -6.211 14.102 1.00 16.58 ? 217 ARG A N 1 ATOM 1442 C CA . ARG A 1 191 ? -0.814 -5.597 13.027 1.00 16.99 ? 217 ARG A CA 1 ATOM 1443 C C . ARG A 1 191 ? -1.452 -4.297 13.498 1.00 16.07 ? 217 ARG A C 1 ATOM 1444 O O . ARG A 1 191 ? -2.050 -4.262 14.569 1.00 15.45 ? 217 ARG A O 1 ATOM 1445 C CB . ARG A 1 191 ? -1.900 -6.573 12.581 1.00 18.31 ? 217 ARG A CB 1 ATOM 1446 C CG . ARG A 1 191 ? -2.925 -5.987 11.634 1.00 19.61 ? 217 ARG A CG 1 ATOM 1447 C CD . ARG A 1 191 ? -3.553 -7.067 10.780 1.00 20.79 ? 217 ARG A CD 1 ATOM 1448 N NE . ARG A 1 191 ? -4.461 -7.912 11.540 1.00 21.90 ? 217 ARG A NE 1 ATOM 1449 C CZ . ARG A 1 191 ? -4.288 -9.204 11.815 1.00 23.08 ? 217 ARG A CZ 1 ATOM 1450 N NH1 . ARG A 1 191 ? -3.215 -9.868 11.406 1.00 23.93 ? 217 ARG A NH1 1 ATOM 1451 N NH2 . ARG A 1 191 ? -5.221 -9.844 12.511 1.00 23.31 ? 217 ARG A NH2 1 ATOM 1452 N N . LEU A 1 192 ? -1.323 -3.243 12.693 1.00 15.40 ? 218 LEU A N 1 ATOM 1453 C CA . LEU A 1 192 ? -1.915 -1.933 12.997 1.00 14.94 ? 218 LEU A CA 1 ATOM 1454 C C . LEU A 1 192 ? -2.638 -1.369 11.774 1.00 14.64 ? 218 LEU A C 1 ATOM 1455 O O . LEU A 1 192 ? -2.099 -1.372 10.674 1.00 14.19 ? 218 LEU A O 1 ATOM 1456 C CB . LEU A 1 192 ? -0.836 -0.944 13.442 1.00 14.80 ? 218 LEU A CB 1 ATOM 1457 C CG . LEU A 1 192 ? -1.279 0.494 13.758 1.00 14.76 ? 218 LEU A CG 1 ATOM 1458 C CD1 . LEU A 1 192 ? -2.266 0.545 14.911 1.00 14.58 ? 218 LEU A CD1 1 ATOM 1459 C CD2 . LEU A 1 192 ? -0.070 1.367 14.067 1.00 14.88 ? 218 LEU A CD2 1 ATOM 1460 N N . GLY A 1 193 ? -3.855 -0.875 11.980 1.00 14.63 ? 219 GLY A N 1 ATOM 1461 C CA . GLY A 1 193 ? -4.613 -0.210 10.922 1.00 14.43 ? 219 GLY A CA 1 ATOM 1462 C C . GLY A 1 193 ? -5.425 0.960 11.440 1.00 14.36 ? 219 GLY A C 1 ATOM 1463 O O . GLY A 1 193 ? -5.427 1.252 12.643 1.00 14.07 ? 219 GLY A O 1 ATOM 1464 N N . GLY A 1 194 ? -6.114 1.630 10.520 1.00 14.26 ? 220 GLY A N 1 ATOM 1465 C CA . GLY A 1 194 ? -6.941 2.795 10.843 1.00 14.33 ? 220 GLY A CA 1 ATOM 1466 C C . GLY A 1 194 ? -7.487 3.396 9.558 1.00 14.36 ? 220 GLY A C 1 ATOM 1467 O O . GLY A 1 194 ? -7.354 2.785 8.500 1.00 13.86 ? 220 GLY A O 1 ATOM 1468 N N . PRO A 1 195 ? -8.103 4.591 9.629 1.00 14.56 ? 221 PRO A N 1 ATOM 1469 C CA . PRO A 1 195 ? -8.373 5.458 10.778 1.00 14.84 ? 221 PRO A CA 1 ATOM 1470 C C . PRO A 1 195 ? -9.655 5.130 11.546 1.00 15.37 ? 221 PRO A C 1 ATOM 1471 O O . PRO A 1 195 ? -9.868 5.675 12.630 1.00 15.86 ? 221 PRO A O 1 ATOM 1472 C CB . PRO A 1 195 ? -8.543 6.831 10.127 1.00 14.76 ? 221 PRO A CB 1 ATOM 1473 C CG . PRO A 1 195 ? -9.173 6.517 8.816 1.00 14.70 ? 221 PRO A CG 1 ATOM 1474 C CD . PRO A 1 195 ? -8.557 5.215 8.372 1.00 14.60 ? 221 PRO A CD 1 ATOM 1475 N N . GLY A 1 196 ? -10.508 4.280 10.979 1.00 15.76 ? 222 GLY A N 1 ATOM 1476 C CA . GLY A 1 196 ? -11.799 3.972 11.573 1.00 16.20 ? 222 GLY A CA 1 ATOM 1477 C C . GLY A 1 196 ? -12.748 5.150 11.482 1.00 16.88 ? 222 GLY A C 1 ATOM 1478 O O . GLY A 1 196 ? -13.237 5.629 12.502 1.00 16.60 ? 222 GLY A O 1 ATOM 1479 N N . ASP A 1 197 ? -12.994 5.622 10.258 1.00 17.87 ? 223 ASP A N 1 ATOM 1480 C CA . ASP A 1 197 ? -13.922 6.737 10.018 1.00 18.51 ? 223 ASP A CA 1 ATOM 1481 C C . ASP A 1 197 ? -14.556 6.672 8.611 1.00 18.31 ? 223 ASP A C 1 ATOM 1482 O O . ASP A 1 197 ? -14.315 5.733 7.857 1.00 18.46 ? 223 ASP A O 1 ATOM 1483 C CB . ASP A 1 197 ? -13.217 8.086 10.246 1.00 19.07 ? 223 ASP A CB 1 ATOM 1484 C CG . ASP A 1 197 ? -14.159 9.163 10.800 1.00 19.62 ? 223 ASP A CG 1 ATOM 1485 O OD1 . ASP A 1 197 ? -15.327 9.226 10.355 1.00 19.68 ? 223 ASP A OD1 1 ATOM 1486 O OD2 . ASP A 1 197 ? -13.735 9.944 11.682 1.00 20.25 ? 223 ASP A OD2 1 ATOM 1487 N N . SER A 1 198 ? -15.350 7.684 8.271 1.00 18.43 ? 224 SER A N 1 ATOM 1488 C CA . SER A 1 198 ? -16.246 7.653 7.114 1.00 18.59 ? 224 SER A CA 1 ATOM 1489 C C . SER A 1 198 ? -15.599 7.859 5.748 1.00 18.66 ? 224 SER A C 1 ATOM 1490 O O . SER A 1 198 ? -16.139 7.393 4.749 1.00 18.29 ? 224 SER A O 1 ATOM 1491 C CB . SER A 1 198 ? -17.333 8.710 7.286 1.00 18.79 ? 224 SER A CB 1 ATOM 1492 O OG . SER A 1 198 ? -18.015 8.525 8.505 1.00 19.17 ? 224 SER A OG 1 ATOM 1493 N N . PHE A 1 199 ? -14.473 8.570 5.696 1.00 19.13 ? 225 PHE A N 1 ATOM 1494 C CA . PHE A 1 199 ? -13.845 8.952 4.421 1.00 19.31 ? 225 PHE A CA 1 ATOM 1495 C C . PHE A 1 199 ? -14.845 9.659 3.496 1.00 19.85 ? 225 PHE A C 1 ATOM 1496 O O . PHE A 1 199 ? -15.047 9.247 2.356 1.00 19.38 ? 225 PHE A O 1 ATOM 1497 C CB . PHE A 1 199 ? -13.258 7.727 3.700 1.00 19.42 ? 225 PHE A CB 1 ATOM 1498 C CG . PHE A 1 199 ? -11.999 7.192 4.314 1.00 19.16 ? 225 PHE A CG 1 ATOM 1499 C CD1 . PHE A 1 199 ? -10.775 7.779 4.030 1.00 19.21 ? 225 PHE A CD1 1 ATOM 1500 C CD2 . PHE A 1 199 ? -12.029 6.082 5.146 1.00 19.17 ? 225 PHE A CD2 1 ATOM 1501 C CE1 . PHE A 1 199 ? -9.605 7.283 4.583 1.00 19.13 ? 225 PHE A CE1 1 ATOM 1502 C CE2 . PHE A 1 199 ? -10.864 5.581 5.701 1.00 19.02 ? 225 PHE A CE2 1 ATOM 1503 C CZ . PHE A 1 199 ? -9.650 6.183 5.417 1.00 18.96 ? 225 PHE A CZ 1 ATOM 1504 N N . HIS A 1 200 ? -15.487 10.711 3.994 1.00 20.77 ? 226 HIS A N 1 ATOM 1505 C CA . HIS A 1 200 ? -16.360 11.530 3.150 1.00 21.51 ? 226 HIS A CA 1 ATOM 1506 C C . HIS A 1 200 ? -15.519 12.330 2.159 1.00 22.20 ? 226 HIS A C 1 ATOM 1507 O O . HIS A 1 200 ? -14.312 12.488 2.338 1.00 21.03 ? 226 HIS A O 1 ATOM 1508 C CB . HIS A 1 200 ? -17.219 12.481 3.988 1.00 21.66 ? 226 HIS A CB 1 ATOM 1509 C CG . HIS A 1 200 ? -18.279 11.790 4.783 1.00 22.41 ? 226 HIS A CG 1 ATOM 1510 N ND1 . HIS A 1 200 ? -18.438 11.983 6.140 1.00 22.74 ? 226 HIS A ND1 1 ATOM 1511 C CD2 . HIS A 1 200 ? -19.225 10.892 4.416 1.00 22.58 ? 226 HIS A CD2 1 ATOM 1512 C CE1 . HIS A 1 200 ? -19.442 11.242 6.572 1.00 22.83 ? 226 HIS A CE1 1 ATOM 1513 N NE2 . HIS A 1 200 ? -19.935 10.570 5.546 1.00 22.83 ? 226 HIS A NE2 1 ATOM 1514 N N . THR A 1 201 ? -16.172 12.831 1.118 1.00 23.92 ? 227 THR A N 1 ATOM 1515 C CA . THR A 1 201 ? -15.506 13.587 0.061 1.00 25.77 ? 227 THR A CA 1 ATOM 1516 C C . THR A 1 201 ? -14.763 14.787 0.639 1.00 26.58 ? 227 THR A C 1 ATOM 1517 O O . THR A 1 201 ? -15.354 15.559 1.391 1.00 27.19 ? 227 THR A O 1 ATOM 1518 C CB . THR A 1 201 ? -16.533 14.097 -0.964 1.00 26.04 ? 227 THR A CB 1 ATOM 1519 O OG1 . THR A 1 201 ? -17.401 13.019 -1.326 1.00 26.02 ? 227 THR A OG1 1 ATOM 1520 C CG2 . THR A 1 201 ? -15.840 14.647 -2.207 1.00 26.29 ? 227 THR A CG2 1 ATOM 1521 N N . PRO A 1 202 ? -13.462 14.937 0.306 1.00 28.12 ? 228 PRO A N 1 ATOM 1522 C CA . PRO A 1 202 ? -12.697 16.122 0.738 1.00 29.21 ? 228 PRO A CA 1 ATOM 1523 C C . PRO A 1 202 ? -13.417 17.424 0.357 1.00 30.34 ? 228 PRO A C 1 ATOM 1524 O O . PRO A 1 202 ? -14.001 17.497 -0.727 1.00 31.69 ? 228 PRO A O 1 ATOM 1525 C CB . PRO A 1 202 ? -11.376 15.990 -0.025 1.00 28.86 ? 228 PRO A CB 1 ATOM 1526 C CG . PRO A 1 202 ? -11.235 14.538 -0.321 1.00 28.50 ? 228 PRO A CG 1 ATOM 1527 C CD . PRO A 1 202 ? -12.626 13.977 -0.439 1.00 28.35 ? 228 PRO A CD 1 ATOM 1528 N N . PRO A 1 203 ? -13.358 18.460 1.215 1.00 31.73 ? 229 PRO A N 1 ATOM 1529 C CA . PRO A 1 203 ? -12.494 18.685 2.380 1.00 31.09 ? 229 PRO A CA 1 ATOM 1530 C C . PRO A 1 203 ? -12.930 17.999 3.677 1.00 30.75 ? 229 PRO A C 1 ATOM 1531 O O . PRO A 1 203 ? -12.325 18.245 4.724 1.00 31.43 ? 229 PRO A O 1 ATOM 1532 C CB . PRO A 1 203 ? -12.590 20.199 2.567 1.00 31.50 ? 229 PRO A CB 1 ATOM 1533 C CG . PRO A 1 203 ? -14.003 20.507 2.184 1.00 31.66 ? 229 PRO A CG 1 ATOM 1534 C CD . PRO A 1 203 ? -14.386 19.517 1.107 1.00 31.74 ? 229 PRO A CD 1 ATOM 1535 N N . ARG A 1 204 ? -13.966 17.163 3.627 1.00 29.66 ? 230 ARG A N 1 ATOM 1536 C CA . ARG A 1 204 ? -14.377 16.415 4.811 1.00 28.29 ? 230 ARG A CA 1 ATOM 1537 C C . ARG A 1 204 ? -13.397 15.283 5.111 1.00 25.59 ? 230 ARG A C 1 ATOM 1538 O O . ARG A 1 204 ? -12.576 14.910 4.271 1.00 24.88 ? 230 ARG A O 1 ATOM 1539 C CB . ARG A 1 204 ? -15.796 15.863 4.657 1.00 29.29 ? 230 ARG A CB 1 ATOM 1540 C CG . ARG A 1 204 ? -16.883 16.909 4.859 1.00 30.09 ? 230 ARG A CG 1 ATOM 1541 C CD . ARG A 1 204 ? -18.183 16.281 5.342 1.00 30.81 ? 230 ARG A CD 1 ATOM 1542 N NE . ARG A 1 204 ? -18.974 15.720 4.246 1.00 31.29 ? 230 ARG A NE 1 ATOM 1543 C CZ . ARG A 1 204 ? -19.992 14.871 4.396 1.00 32.14 ? 230 ARG A CZ 1 ATOM 1544 N NH1 . ARG A 1 204 ? -20.360 14.444 5.603 1.00 31.82 ? 230 ARG A NH1 1 ATOM 1545 N NH2 . ARG A 1 204 ? -20.643 14.431 3.324 1.00 33.01 ? 230 ARG A NH2 1 ATOM 1546 N N . SER A 1 205 ? -13.495 14.754 6.325 1.00 23.41 ? 231 SER A N 1 ATOM 1547 C CA . SER A 1 205 ? -12.644 13.665 6.793 1.00 22.04 ? 231 SER A CA 1 ATOM 1548 C C . SER A 1 205 ? -11.149 13.957 6.602 1.00 21.01 ? 231 SER A C 1 ATOM 1549 O O . SER A 1 205 ? -10.418 13.112 6.087 1.00 20.02 ? 231 SER A O 1 ATOM 1550 C CB . SER A 1 205 ? -13.027 12.358 6.084 1.00 21.95 ? 231 SER A CB 1 ATOM 1551 O OG . SER A 1 205 ? -14.416 12.115 6.188 1.00 21.64 ? 231 SER A OG 1 ATOM 1552 N N . PRO A 1 206 ? -10.687 15.151 7.028 1.00 20.18 ? 232 PRO A N 1 ATOM 1553 C CA . PRO A 1 206 ? -9.286 15.505 6.768 1.00 19.55 ? 232 PRO A CA 1 ATOM 1554 C C . PRO A 1 206 ? -8.259 14.599 7.472 1.00 18.86 ? 232 PRO A C 1 ATOM 1555 O O . PRO A 1 206 ? -7.243 14.258 6.864 1.00 18.52 ? 232 PRO A O 1 ATOM 1556 C CB . PRO A 1 206 ? -9.184 16.955 7.261 1.00 19.61 ? 232 PRO A CB 1 ATOM 1557 C CG . PRO A 1 206 ? -10.300 17.118 8.235 1.00 19.86 ? 232 PRO A CG 1 ATOM 1558 C CD . PRO A 1 206 ? -11.402 16.216 7.757 1.00 20.02 ? 232 PRO A CD 1 ATOM 1559 N N . LEU A 1 207 ? -8.513 14.207 8.722 1.00 18.15 ? 233 LEU A N 1 ATOM 1560 C CA . LEU A 1 207 ? -7.567 13.334 9.435 1.00 17.78 ? 233 LEU A CA 1 ATOM 1561 C C . LEU A 1 207 ? -7.497 11.944 8.793 1.00 17.05 ? 233 LEU A C 1 ATOM 1562 O O . LEU A 1 207 ? -6.421 11.340 8.734 1.00 16.42 ? 233 LEU A O 1 ATOM 1563 C CB . LEU A 1 207 ? -7.896 13.192 10.927 1.00 17.92 ? 233 LEU A CB 1 ATOM 1564 C CG . LEU A 1 207 ? -8.051 14.414 11.852 1.00 18.35 ? 233 LEU A CG 1 ATOM 1565 C CD1 . LEU A 1 207 ? -7.471 14.097 13.220 1.00 18.19 ? 233 LEU A CD1 1 ATOM 1566 C CD2 . LEU A 1 207 ? -7.429 15.695 11.317 1.00 18.56 ? 233 LEU A CD2 1 ATOM 1567 N N . SER A 1 208 ? -8.638 11.453 8.307 1.00 16.27 ? 234 SER A N 1 ATOM 1568 C CA . SER A 1 208 ? -8.716 10.121 7.690 1.00 15.97 ? 234 SER A CA 1 ATOM 1569 C C . SER A 1 208 ? -7.958 10.058 6.368 1.00 15.59 ? 234 SER A C 1 ATOM 1570 O O . SER A 1 208 ? -7.164 9.148 6.145 1.00 15.11 ? 234 SER A O 1 ATOM 1571 C CB . SER A 1 208 ? -10.173 9.725 7.449 1.00 15.84 ? 234 SER A CB 1 ATOM 1572 O OG . SER A 1 208 ? -10.885 9.675 8.663 1.00 16.04 ? 234 SER A OG 1 ATOM 1573 N N . TRP A 1 209 ? -8.226 11.022 5.491 1.00 15.43 ? 235 TRP A N 1 ATOM 1574 C CA . TRP A 1 209 ? -7.479 11.154 4.240 1.00 15.47 ? 235 TRP A CA 1 ATOM 1575 C C . TRP A 1 209 ? -6.028 11.531 4.531 1.00 15.46 ? 235 TRP A C 1 ATOM 1576 O O . TRP A 1 209 ? -5.114 11.101 3.826 1.00 15.26 ? 235 TRP A O 1 ATOM 1577 C CB . TRP A 1 209 ? -8.130 12.200 3.317 1.00 15.50 ? 235 TRP A CB 1 ATOM 1578 C CG . TRP A 1 209 ? -9.464 11.781 2.774 1.00 15.58 ? 235 TRP A CG 1 ATOM 1579 C CD1 . TRP A 1 209 ? -10.678 12.325 3.071 1.00 15.70 ? 235 TRP A CD1 1 ATOM 1580 C CD2 . TRP A 1 209 ? -9.722 10.711 1.848 1.00 15.85 ? 235 TRP A CD2 1 ATOM 1581 N NE1 . TRP A 1 209 ? -11.675 11.672 2.383 1.00 15.84 ? 235 TRP A NE1 1 ATOM 1582 C CE2 . TRP A 1 209 ? -11.115 10.678 1.624 1.00 15.93 ? 235 TRP A CE2 1 ATOM 1583 C CE3 . TRP A 1 209 ? -8.910 9.786 1.182 1.00 15.96 ? 235 TRP A CE3 1 ATOM 1584 C CZ2 . TRP A 1 209 ? -11.715 9.754 0.764 1.00 16.04 ? 235 TRP A CZ2 1 ATOM 1585 C CZ3 . TRP A 1 209 ? -9.510 8.862 0.330 1.00 16.02 ? 235 TRP A CZ3 1 ATOM 1586 C CH2 . TRP A 1 209 ? -10.898 8.857 0.129 1.00 16.09 ? 235 TRP A CH2 1 ATOM 1587 N N . GLY A 1 210 ? -5.831 12.327 5.583 1.00 15.49 ? 236 GLY A N 1 ATOM 1588 C CA . GLY A 1 210 ? -4.501 12.750 6.020 1.00 15.48 ? 236 GLY A CA 1 ATOM 1589 C C . GLY A 1 210 ? -3.629 11.595 6.467 1.00 15.54 ? 236 GLY A C 1 ATOM 1590 O O . GLY A 1 210 ? -2.427 11.580 6.187 1.00 15.38 ? 236 GLY A O 1 ATOM 1591 N N . LEU A 1 211 ? -4.230 10.619 7.149 1.00 15.51 ? 237 LEU A N 1 ATOM 1592 C CA . LEU A 1 211 ? -3.505 9.407 7.546 1.00 15.66 ? 237 LEU A CA 1 ATOM 1593 C C . LEU A 1 211 ? -3.001 8.636 6.326 1.00 15.68 ? 237 LEU A C 1 ATOM 1594 O O . LEU A 1 211 ? -1.841 8.221 6.288 1.00 15.72 ? 237 LEU A O 1 ATOM 1595 C CB . LEU A 1 211 ? -4.381 8.487 8.410 1.00 15.62 ? 237 LEU A CB 1 ATOM 1596 C CG . LEU A 1 211 ? -3.703 7.199 8.908 1.00 15.78 ? 237 LEU A CG 1 ATOM 1597 C CD1 . LEU A 1 211 ? -2.525 7.519 9.817 1.00 15.75 ? 237 LEU A CD1 1 ATOM 1598 C CD2 . LEU A 1 211 ? -4.687 6.278 9.621 1.00 15.64 ? 237 LEU A CD2 1 ATOM 1599 N N . LEU A 1 212 ? -3.873 8.448 5.335 1.00 15.90 ? 238 LEU A N 1 ATOM 1600 C CA . LEU A 1 212 ? -3.501 7.718 4.121 1.00 16.32 ? 238 LEU A CA 1 ATOM 1601 C C . LEU A 1 212 ? -2.374 8.428 3.383 1.00 16.53 ? 238 LEU A C 1 ATOM 1602 O O . LEU A 1 212 ? -1.419 7.795 2.953 1.00 16.02 ? 238 LEU A O 1 ATOM 1603 C CB . LEU A 1 212 ? -4.707 7.535 3.189 1.00 16.39 ? 238 LEU A CB 1 ATOM 1604 C CG . LEU A 1 212 ? -5.885 6.715 3.729 1.00 16.65 ? 238 LEU A CG 1 ATOM 1605 C CD1 . LEU A 1 212 ? -6.866 6.389 2.606 1.00 16.71 ? 238 LEU A CD1 1 ATOM 1606 C CD2 . LEU A 1 212 ? -5.413 5.437 4.408 1.00 16.65 ? 238 LEU A CD2 1 ATOM 1607 N N . ARG A 1 213 ? -2.491 9.747 3.267 1.00 17.36 ? 239 ARG A N 1 ATOM 1608 C CA . ARG A 1 213 ? -1.468 10.572 2.631 1.00 18.44 ? 239 ARG A CA 1 ATOM 1609 C C . ARG A 1 213 ? -0.136 10.470 3.386 1.00 17.36 ? 239 ARG A C 1 ATOM 1610 O O . ARG A 1 213 ? 0.926 10.369 2.778 1.00 17.12 ? 239 ARG A O 1 ATOM 1611 C CB . ARG A 1 213 ? -1.954 12.023 2.570 1.00 20.62 ? 239 ARG A CB 1 ATOM 1612 C CG . ARG A 1 213 ? -1.215 12.918 1.590 1.00 22.88 ? 239 ARG A CG 1 ATOM 1613 C CD . ARG A 1 213 ? -2.114 14.061 1.109 1.00 24.56 ? 239 ARG A CD 1 ATOM 1614 N NE . ARG A 1 213 ? -2.520 14.948 2.207 1.00 26.37 ? 239 ARG A NE 1 ATOM 1615 C CZ . ARG A 1 213 ? -3.753 15.073 2.709 1.00 27.68 ? 239 ARG A CZ 1 ATOM 1616 N NH1 . ARG A 1 213 ? -4.783 14.378 2.229 1.00 28.68 ? 239 ARG A NH1 1 ATOM 1617 N NH2 . ARG A 1 213 ? -3.959 15.920 3.712 1.00 28.21 ? 239 ARG A NH2 1 ATOM 1618 N N . HIS A 1 214 ? -0.215 10.483 4.714 1.00 16.25 ? 240 HIS A N 1 ATOM 1619 C CA . HIS A 1 214 ? 0.954 10.365 5.578 1.00 15.62 ? 240 HIS A CA 1 ATOM 1620 C C . HIS A 1 214 ? 1.629 8.998 5.437 1.00 15.38 ? 240 HIS A C 1 ATOM 1621 O O . HIS A 1 214 ? 2.840 8.910 5.227 1.00 14.74 ? 240 HIS A O 1 ATOM 1622 C CB . HIS A 1 214 ? 0.537 10.600 7.033 1.00 15.43 ? 240 HIS A CB 1 ATOM 1623 C CG . HIS A 1 214 ? 1.572 10.204 8.036 1.00 15.26 ? 240 HIS A CG 1 ATOM 1624 N ND1 . HIS A 1 214 ? 2.717 10.936 8.254 1.00 15.20 ? 240 HIS A ND1 1 ATOM 1625 C CD2 . HIS A 1 214 ? 1.627 9.154 8.889 1.00 15.19 ? 240 HIS A CD2 1 ATOM 1626 C CE1 . HIS A 1 214 ? 3.434 10.355 9.198 1.00 15.17 ? 240 HIS A CE1 1 ATOM 1627 N NE2 . HIS A 1 214 ? 2.795 9.272 9.600 1.00 14.99 ? 240 HIS A NE2 1 ATOM 1628 N N . CYS A 1 215 ? 0.838 7.936 5.548 1.00 15.20 ? 241 CYS A N 1 ATOM 1629 C CA . CYS A 1 215 ? 1.375 6.577 5.435 1.00 15.21 ? 241 CYS A CA 1 ATOM 1630 C C . CYS A 1 215 ? 1.930 6.290 4.039 1.00 15.31 ? 241 CYS A C 1 ATOM 1631 O O . CYS A 1 215 ? 2.962 5.634 3.900 1.00 15.41 ? 241 CYS A O 1 ATOM 1632 C CB . CYS A 1 215 ? 0.308 5.553 5.823 1.00 15.10 ? 241 CYS A CB 1 ATOM 1633 S SG . CYS A 1 215 ? -0.119 5.639 7.580 1.00 15.04 ? 241 CYS A SG 1 ATOM 1634 N N . HIS A 1 216 ? 1.253 6.805 3.020 1.00 15.45 ? 242 HIS A N 1 ATOM 1635 C CA . HIS A 1 216 ? 1.645 6.610 1.622 1.00 15.50 ? 242 HIS A CA 1 ATOM 1636 C C . HIS A 1 216 ? 2.821 7.513 1.213 1.00 15.64 ? 242 HIS A C 1 ATOM 1637 O O . HIS A 1 216 ? 3.751 7.058 0.548 1.00 15.45 ? 242 HIS A O 1 ATOM 1638 C CB . HIS A 1 216 ? 0.421 6.882 0.733 1.00 15.42 ? 242 HIS A CB 1 ATOM 1639 C CG . HIS A 1 216 ? 0.539 6.368 -0.667 1.00 15.37 ? 242 HIS A CG 1 ATOM 1640 N ND1 . HIS A 1 216 ? 1.362 6.946 -1.608 1.00 15.56 ? 242 HIS A ND1 1 ATOM 1641 C CD2 . HIS A 1 216 ? -0.105 5.359 -1.302 1.00 15.48 ? 242 HIS A CD2 1 ATOM 1642 C CE1 . HIS A 1 216 ? 1.242 6.302 -2.755 1.00 15.58 ? 242 HIS A CE1 1 ATOM 1643 N NE2 . HIS A 1 216 ? 0.352 5.340 -2.599 1.00 15.54 ? 242 HIS A NE2 1 ATOM 1644 N N . ASP A 1 217 ? 2.778 8.783 1.622 1.00 15.86 ? 243 ASP A N 1 ATOM 1645 C CA . ASP A 1 217 ? 3.666 9.827 1.065 1.00 16.03 ? 243 ASP A CA 1 ATOM 1646 C C . ASP A 1 217 ? 4.435 10.675 2.076 1.00 16.43 ? 243 ASP A C 1 ATOM 1647 O O . ASP A 1 217 ? 5.259 11.493 1.676 1.00 17.04 ? 243 ASP A O 1 ATOM 1648 C CB . ASP A 1 217 ? 2.826 10.769 0.195 1.00 15.82 ? 243 ASP A CB 1 ATOM 1649 C CG . ASP A 1 217 ? 2.055 10.021 -0.873 1.00 15.64 ? 243 ASP A CG 1 ATOM 1650 O OD1 . ASP A 1 217 ? 2.681 9.184 -1.548 1.00 14.90 ? 243 ASP A OD1 1 ATOM 1651 O OD2 . ASP A 1 217 ? 0.835 10.238 -1.035 1.00 15.54 ? 243 ASP A OD2 1 ATOM 1652 N N . GLY A 1 218 ? 4.174 10.488 3.367 1.00 16.60 ? 244 GLY A N 1 ATOM 1653 C CA . GLY A 1 218 ? 4.723 11.354 4.404 1.00 16.69 ? 244 GLY A CA 1 ATOM 1654 C C . GLY A 1 218 ? 6.034 10.849 4.976 1.00 16.95 ? 244 GLY A C 1 ATOM 1655 O O . GLY A 1 218 ? 6.725 10.040 4.359 1.00 17.03 ? 244 GLY A O 1 ATOM 1656 N N . THR A 1 219 ? 6.358 11.330 6.173 1.00 17.15 ? 245 THR A N 1 ATOM 1657 C CA . THR A 1 219 ? 7.631 11.053 6.827 1.00 17.16 ? 245 THR A CA 1 ATOM 1658 C C . THR A 1 219 ? 7.376 10.505 8.230 1.00 16.81 ? 245 THR A C 1 ATOM 1659 O O . THR A 1 219 ? 6.577 11.061 8.976 1.00 16.53 ? 245 THR A O 1 ATOM 1660 C CB . THR A 1 219 ? 8.477 12.346 6.917 1.00 17.60 ? 245 THR A CB 1 ATOM 1661 O OG1 . THR A 1 219 ? 8.709 12.855 5.597 1.00 18.08 ? 245 THR A OG1 1 ATOM 1662 C CG2 . THR A 1 219 ? 9.824 12.099 7.593 1.00 17.92 ? 245 THR A CG2 1 ATOM 1663 N N . ASN A 1 220 ? 8.066 9.422 8.578 1.00 16.72 ? 246 ASN A N 1 ATOM 1664 C CA . ASN A 1 220 ? 7.972 8.813 9.902 1.00 16.68 ? 246 ASN A CA 1 ATOM 1665 C C . ASN A 1 220 ? 8.552 9.762 10.961 1.00 16.90 ? 246 ASN A C 1 ATOM 1666 O O . ASN A 1 220 ? 9.730 10.125 10.896 1.00 17.21 ? 246 ASN A O 1 ATOM 1667 C CB . ASN A 1 220 ? 8.712 7.469 9.899 1.00 16.71 ? 246 ASN A CB 1 ATOM 1668 C CG . ASN A 1 220 ? 8.482 6.652 11.168 1.00 16.93 ? 246 ASN A CG 1 ATOM 1669 O OD1 . ASN A 1 220 ? 8.694 7.136 12.286 1.00 16.79 ? 246 ASN A OD1 1 ATOM 1670 N ND2 . ASN A 1 220 ? 8.078 5.393 10.998 1.00 16.64 ? 246 ASN A ND2 1 ATOM 1671 N N . PHE A 1 221 ? 7.716 10.161 11.919 1.00 16.61 ? 247 PHE A N 1 ATOM 1672 C CA . PHE A 1 221 ? 8.118 11.042 13.020 1.00 16.80 ? 247 PHE A CA 1 ATOM 1673 C C . PHE A 1 221 ? 9.429 10.608 13.685 1.00 16.70 ? 247 PHE A C 1 ATOM 1674 O O . PHE A 1 221 ? 10.264 11.442 14.001 1.00 16.37 ? 247 PHE A O 1 ATOM 1675 C CB . PHE A 1 221 ? 7.001 11.076 14.072 1.00 16.96 ? 247 PHE A CB 1 ATOM 1676 C CG . PHE A 1 221 ? 7.289 11.961 15.258 1.00 17.25 ? 247 PHE A CG 1 ATOM 1677 C CD1 . PHE A 1 221 ? 6.905 13.298 15.254 1.00 17.36 ? 247 PHE A CD1 1 ATOM 1678 C CD2 . PHE A 1 221 ? 7.910 11.449 16.394 1.00 17.41 ? 247 PHE A CD2 1 ATOM 1679 C CE1 . PHE A 1 221 ? 7.147 14.109 16.349 1.00 17.51 ? 247 PHE A CE1 1 ATOM 1680 C CE2 . PHE A 1 221 ? 8.159 12.260 17.491 1.00 17.46 ? 247 PHE A CE2 1 ATOM 1681 C CZ . PHE A 1 221 ? 7.778 13.591 17.468 1.00 17.54 ? 247 PHE A CZ 1 ATOM 1682 N N . PHE A 1 222 ? 9.599 9.305 13.891 1.00 16.77 ? 248 PHE A N 1 ATOM 1683 C CA . PHE A 1 222 ? 10.739 8.780 14.651 1.00 17.10 ? 248 PHE A CA 1 ATOM 1684 C C . PHE A 1 222 ? 11.989 8.507 13.822 1.00 17.58 ? 248 PHE A C 1 ATOM 1685 O O . PHE A 1 222 ? 13.081 8.918 14.194 1.00 18.31 ? 248 PHE A O 1 ATOM 1686 C CB . PHE A 1 222 ? 10.332 7.499 15.382 1.00 16.66 ? 248 PHE A CB 1 ATOM 1687 C CG . PHE A 1 222 ? 9.326 7.729 16.459 1.00 16.54 ? 248 PHE A CG 1 ATOM 1688 C CD1 . PHE A 1 222 ? 9.733 8.034 17.752 1.00 16.58 ? 248 PHE A CD1 1 ATOM 1689 C CD2 . PHE A 1 222 ? 7.974 7.674 16.179 1.00 16.48 ? 248 PHE A CD2 1 ATOM 1690 C CE1 . PHE A 1 222 ? 8.804 8.266 18.750 1.00 16.63 ? 248 PHE A CE1 1 ATOM 1691 C CE2 . PHE A 1 222 ? 7.040 7.902 17.169 1.00 16.56 ? 248 PHE A CE2 1 ATOM 1692 C CZ . PHE A 1 222 ? 7.452 8.193 18.460 1.00 16.61 ? 248 PHE A CZ 1 ATOM 1693 N N . THR A 1 223 ? 11.826 7.799 12.714 1.00 18.39 ? 249 THR A N 1 ATOM 1694 C CA . THR A 1 223 ? 12.963 7.337 11.917 1.00 18.89 ? 249 THR A CA 1 ATOM 1695 C C . THR A 1 223 ? 13.302 8.267 10.756 1.00 19.31 ? 249 THR A C 1 ATOM 1696 O O . THR A 1 223 ? 14.394 8.193 10.209 1.00 19.66 ? 249 THR A O 1 ATOM 1697 C CB . THR A 1 223 ? 12.679 5.949 11.329 1.00 18.95 ? 249 THR A CB 1 ATOM 1698 O OG1 . THR A 1 223 ? 11.608 6.047 10.384 1.00 19.19 ? 249 THR A OG1 1 ATOM 1699 C CG2 . THR A 1 223 ? 12.300 4.962 12.435 1.00 18.85 ? 249 THR A CG2 1 ATOM 1700 N N . GLY A 1 224 ? 12.360 9.121 10.366 1.00 19.85 ? 250 GLY A N 1 ATOM 1701 C CA . GLY A 1 224 ? 12.559 10.019 9.233 1.00 20.13 ? 250 GLY A CA 1 ATOM 1702 C C . GLY A 1 224 ? 12.466 9.361 7.861 1.00 20.66 ? 250 GLY A C 1 ATOM 1703 O O . GLY A 1 224 ? 12.758 10.002 6.850 1.00 20.68 ? 250 GLY A O 1 ATOM 1704 N N . GLU A 1 225 ? 12.055 8.094 7.805 1.00 21.06 ? 251 GLU A N 1 ATOM 1705 C CA . GLU A 1 225 ? 11.935 7.407 6.520 1.00 21.65 ? 251 GLU A CA 1 ATOM 1706 C C . GLU A 1 225 ? 10.635 7.777 5.810 1.00 20.67 ? 251 GLU A C 1 ATOM 1707 O O . GLU A 1 225 ? 9.729 8.359 6.411 1.00 20.31 ? 251 GLU A O 1 ATOM 1708 C CB . GLU A 1 225 ? 12.074 5.891 6.681 1.00 23.23 ? 251 GLU A CB 1 ATOM 1709 C CG . GLU A 1 225 ? 10.946 5.200 7.420 1.00 24.64 ? 251 GLU A CG 1 ATOM 1710 C CD . GLU A 1 225 ? 11.415 3.933 8.121 1.00 26.35 ? 251 GLU A CD 1 ATOM 1711 O OE1 . GLU A 1 225 ? 12.242 3.193 7.529 1.00 26.95 ? 251 GLU A OE1 1 ATOM 1712 O OE2 . GLU A 1 225 ? 10.962 3.687 9.265 1.00 26.39 ? 251 GLU A OE2 1 ATOM 1713 N N . ALA A 1 226 ? 10.566 7.449 4.522 1.00 19.59 ? 252 ALA A N 1 ATOM 1714 C CA . ALA A 1 226 ? 9.432 7.828 3.678 1.00 19.01 ? 252 ALA A CA 1 ATOM 1715 C C . ALA A 1 226 ? 8.277 6.850 3.855 1.00 18.47 ? 252 ALA A C 1 ATOM 1716 O O . ALA A 1 226 ? 8.464 5.638 3.768 1.00 18.77 ? 252 ALA A O 1 ATOM 1717 C CB . ALA A 1 226 ? 9.854 7.888 2.217 1.00 18.97 ? 252 ALA A CB 1 ATOM 1718 N N . GLY A 1 227 ? 7.088 7.388 4.112 1.00 17.83 ? 253 GLY A N 1 ATOM 1719 C CA . GLY A 1 227 ? 5.896 6.580 4.353 1.00 17.20 ? 253 GLY A CA 1 ATOM 1720 C C . GLY A 1 227 ? 5.948 5.794 5.651 1.00 16.60 ? 253 GLY A C 1 ATOM 1721 O O . GLY A 1 227 ? 7.005 5.659 6.262 1.00 16.66 ? 253 GLY A O 1 ATOM 1722 N N . VAL A 1 228 ? 4.797 5.272 6.070 1.00 15.90 ? 254 VAL A N 1 ATOM 1723 C CA . VAL A 1 228 ? 4.686 4.517 7.325 1.00 15.22 ? 254 VAL A CA 1 ATOM 1724 C C . VAL A 1 228 ? 3.749 3.320 7.164 1.00 14.86 ? 254 VAL A C 1 ATOM 1725 O O . VAL A 1 228 ? 2.765 3.374 6.416 1.00 14.99 ? 254 VAL A O 1 ATOM 1726 C CB . VAL A 1 228 ? 4.165 5.401 8.476 1.00 15.19 ? 254 VAL A CB 1 ATOM 1727 C CG1 . VAL A 1 228 ? 4.214 4.647 9.803 1.00 15.23 ? 254 VAL A CG1 1 ATOM 1728 C CG2 . VAL A 1 228 ? 4.973 6.691 8.569 1.00 15.27 ? 254 VAL A CG2 1 ATOM 1729 N N . ARG A 1 229 ? 4.067 2.245 7.878 1.00 14.24 ? 255 ARG A N 1 ATOM 1730 C CA . ARG A 1 229 ? 3.242 1.038 7.919 1.00 13.77 ? 255 ARG A CA 1 ATOM 1731 C C . ARG A 1 229 ? 1.760 1.358 8.127 1.00 13.31 ? 255 ARG A C 1 ATOM 1732 O O . ARG A 1 229 ? 1.412 2.224 8.911 1.00 13.33 ? 255 ARG A O 1 ATOM 1733 C CB . ARG A 1 229 ? 3.750 0.104 9.032 1.00 13.58 ? 255 ARG A CB 1 ATOM 1734 C CG . ARG A 1 229 ? 2.822 -1.042 9.415 1.00 13.45 ? 255 ARG A CG 1 ATOM 1735 C CD . ARG A 1 229 ? 1.924 -0.699 10.601 1.00 13.41 ? 255 ARG A CD 1 ATOM 1736 N NE . ARG A 1 229 ? 2.658 -0.729 11.863 1.00 13.36 ? 255 ARG A NE 1 ATOM 1737 C CZ . ARG A 1 229 ? 2.882 -1.815 12.603 1.00 13.16 ? 255 ARG A CZ 1 ATOM 1738 N NH1 . ARG A 1 229 ? 2.419 -3.006 12.240 1.00 13.08 ? 255 ARG A NH1 1 ATOM 1739 N NH2 . ARG A 1 229 ? 3.579 -1.706 13.729 1.00 13.14 ? 255 ARG A NH2 1 ATOM 1740 N N . LEU A 1 230 ? 0.910 0.650 7.397 1.00 13.25 ? 256 LEU A N 1 ATOM 1741 C CA . LEU A 1 230 ? -0.539 0.688 7.572 1.00 13.29 ? 256 LEU A CA 1 ATOM 1742 C C . LEU A 1 230 ? -1.074 -0.660 7.080 1.00 13.03 ? 256 LEU A C 1 ATOM 1743 O O . LEU A 1 230 ? -1.283 -0.855 5.892 1.00 13.21 ? 256 LEU A O 1 ATOM 1744 C CB . LEU A 1 230 ? -1.146 1.865 6.796 1.00 13.30 ? 256 LEU A CB 1 ATOM 1745 C CG . LEU A 1 230 ? -2.666 2.074 6.857 1.00 13.47 ? 256 LEU A CG 1 ATOM 1746 C CD1 . LEU A 1 230 ? -3.124 2.467 8.255 1.00 13.38 ? 256 LEU A CD1 1 ATOM 1747 C CD2 . LEU A 1 230 ? -3.089 3.137 5.853 1.00 13.47 ? 256 LEU A CD2 1 ATOM 1748 N N . ASP A 1 231 ? -1.256 -1.603 7.996 1.00 12.89 ? 257 ASP A N 1 ATOM 1749 C CA . ASP A 1 231 ? -1.540 -2.992 7.610 1.00 12.74 ? 257 ASP A CA 1 ATOM 1750 C C . ASP A 1 231 ? -2.960 -3.212 7.082 1.00 12.56 ? 257 ASP A C 1 ATOM 1751 O O . ASP A 1 231 ? -3.196 -4.121 6.297 1.00 12.53 ? 257 ASP A O 1 ATOM 1752 C CB . ASP A 1 231 ? -1.245 -3.933 8.775 1.00 12.68 ? 257 ASP A CB 1 ATOM 1753 C CG . ASP A 1 231 ? 0.226 -3.963 9.133 1.00 12.80 ? 257 ASP A CG 1 ATOM 1754 O OD1 . ASP A 1 231 ? 1.060 -4.023 8.202 1.00 12.74 ? 257 ASP A OD1 1 ATOM 1755 O OD2 . ASP A 1 231 ? 0.555 -3.924 10.339 1.00 12.81 ? 257 ASP A OD2 1 ATOM 1756 N N . TYR A 1 232 ? -3.900 -2.393 7.527 1.00 12.46 ? 258 TYR A N 1 ATOM 1757 C CA . TYR A 1 232 ? -5.240 -2.389 6.963 1.00 12.39 ? 258 TYR A CA 1 ATOM 1758 C C . TYR A 1 232 ? -5.846 -1.006 7.086 1.00 12.50 ? 258 TYR A C 1 ATOM 1759 O O . TYR A 1 232 ? -5.405 -0.201 7.902 1.00 12.25 ? 258 TYR A O 1 ATOM 1760 C CB . TYR A 1 232 ? -6.129 -3.419 7.656 1.00 12.36 ? 258 TYR A CB 1 ATOM 1761 C CG . TYR A 1 232 ? -6.407 -3.147 9.119 1.00 12.37 ? 258 TYR A CG 1 ATOM 1762 C CD1 . TYR A 1 232 ? -7.478 -2.345 9.508 1.00 12.33 ? 258 TYR A CD1 1 ATOM 1763 C CD2 . TYR A 1 232 ? -5.613 -3.708 10.116 1.00 12.32 ? 258 TYR A CD2 1 ATOM 1764 C CE1 . TYR A 1 232 ? -7.738 -2.097 10.845 1.00 12.40 ? 258 TYR A CE1 1 ATOM 1765 C CE2 . TYR A 1 232 ? -5.868 -3.467 11.458 1.00 12.38 ? 258 TYR A CE2 1 ATOM 1766 C CZ . TYR A 1 232 ? -6.935 -2.663 11.819 1.00 12.42 ? 258 TYR A CZ 1 ATOM 1767 O OH . TYR A 1 232 ? -7.197 -2.420 13.150 1.00 12.35 ? 258 TYR A OH 1 ATOM 1768 N N . ILE A 1 233 ? -6.857 -0.744 6.265 1.00 12.63 ? 259 ILE A N 1 ATOM 1769 C CA . ILE A 1 233 ? -7.597 0.499 6.315 1.00 12.72 ? 259 ILE A CA 1 ATOM 1770 C C . ILE A 1 233 ? -9.001 0.197 6.819 1.00 13.16 ? 259 ILE A C 1 ATOM 1771 O O . ILE A 1 233 ? -9.716 -0.609 6.229 1.00 13.22 ? 259 ILE A O 1 ATOM 1772 C CB . ILE A 1 233 ? -7.647 1.168 4.929 1.00 12.70 ? 259 ILE A CB 1 ATOM 1773 C CG1 . ILE A 1 233 ? -6.230 1.566 4.500 1.00 12.57 ? 259 ILE A CG1 1 ATOM 1774 C CG2 . ILE A 1 233 ? -8.541 2.403 4.943 1.00 12.60 ? 259 ILE A CG2 1 ATOM 1775 C CD1 . ILE A 1 233 ? -6.083 1.793 3.019 1.00 12.64 ? 259 ILE A CD1 1 ATOM 1776 N N . SER A 1 234 ? -9.390 0.835 7.918 1.00 13.43 ? 260 SER A N 1 ATOM 1777 C CA . SER A 1 234 ? -10.720 0.641 8.476 1.00 13.90 ? 260 SER A CA 1 ATOM 1778 C C . SER A 1 234 ? -11.590 1.868 8.241 1.00 14.21 ? 260 SER A C 1 ATOM 1779 O O . SER A 1 234 ? -11.195 2.991 8.548 1.00 14.39 ? 260 SER A O 1 ATOM 1780 C CB . SER A 1 234 ? -10.649 0.339 9.971 1.00 13.89 ? 260 SER A CB 1 ATOM 1781 O OG . SER A 1 234 ? -9.928 1.332 10.662 1.00 13.73 ? 260 SER A OG 1 ATOM 1782 N N . LEU A 1 235 ? -12.774 1.635 7.689 1.00 14.58 ? 261 LEU A N 1 ATOM 1783 C CA . LEU A 1 235 ? -13.751 2.686 7.485 1.00 14.78 ? 261 LEU A CA 1 ATOM 1784 C C . LEU A 1 235 ? -15.016 2.372 8.273 1.00 14.76 ? 261 LEU A C 1 ATOM 1785 O O . LEU A 1 235 ? -15.199 1.255 8.775 1.00 14.43 ? 261 LEU A O 1 ATOM 1786 C CB . LEU A 1 235 ? -14.059 2.870 5.990 1.00 15.22 ? 261 LEU A CB 1 ATOM 1787 C CG . LEU A 1 235 ? -14.500 1.663 5.156 1.00 15.42 ? 261 LEU A CG 1 ATOM 1788 C CD1 . LEU A 1 235 ? -15.940 1.266 5.458 1.00 15.74 ? 261 LEU A CD1 1 ATOM 1789 C CD2 . LEU A 1 235 ? -14.335 1.949 3.671 1.00 15.56 ? 261 LEU A CD2 1 ATOM 1790 N N . HIS A 1 236 ? -15.865 3.383 8.415 1.00 14.71 ? 262 HIS A N 1 ATOM 1791 C CA . HIS A 1 236 ? -17.211 3.211 8.957 1.00 14.82 ? 262 HIS A CA 1 ATOM 1792 C C . HIS A 1 236 ? -18.173 3.688 7.884 1.00 14.64 ? 262 HIS A C 1 ATOM 1793 O O . HIS A 1 236 ? -18.125 4.850 7.491 1.00 14.72 ? 262 HIS A O 1 ATOM 1794 C CB . HIS A 1 236 ? -17.443 4.085 10.195 1.00 14.75 ? 262 HIS A CB 1 ATOM 1795 C CG . HIS A 1 236 ? -16.614 3.729 11.393 1.00 14.88 ? 262 HIS A CG 1 ATOM 1796 N ND1 . HIS A 1 236 ? -15.677 2.715 11.409 1.00 15.20 ? 262 HIS A ND1 1 ATOM 1797 C CD2 . HIS A 1 236 ? -16.565 4.298 12.618 1.00 14.95 ? 262 HIS A CD2 1 ATOM 1798 C CE1 . HIS A 1 236 ? -15.106 2.663 12.599 1.00 14.94 ? 262 HIS A CE1 1 ATOM 1799 N NE2 . HIS A 1 236 ? -15.625 3.616 13.349 1.00 15.14 ? 262 HIS A NE2 1 ATOM 1800 N N . ARG A 1 237 ? -19.042 2.812 7.404 1.00 14.49 ? 263 ARG A N 1 ATOM 1801 C CA . ARG A 1 237 ? -20.153 3.261 6.580 1.00 14.55 ? 263 ARG A CA 1 ATOM 1802 C C . ARG A 1 237 ? -21.409 2.524 6.988 1.00 14.65 ? 263 ARG A C 1 ATOM 1803 O O . ARG A 1 237 ? -21.439 1.293 7.021 1.00 14.86 ? 263 ARG A O 1 ATOM 1804 C CB . ARG A 1 237 ? -19.865 3.081 5.087 1.00 14.39 ? 263 ARG A CB 1 ATOM 1805 C CG . ARG A 1 237 ? -18.872 4.088 4.514 1.00 14.20 ? 263 ARG A CG 1 ATOM 1806 C CD . ARG A 1 237 ? -19.365 5.524 4.653 1.00 13.95 ? 263 ARG A CD 1 ATOM 1807 N NE . ARG A 1 237 ? -18.510 6.448 3.912 1.00 13.73 ? 263 ARG A NE 1 ATOM 1808 C CZ . ARG A 1 237 ? -18.895 7.227 2.899 1.00 13.47 ? 263 ARG A CZ 1 ATOM 1809 N NH1 . ARG A 1 237 ? -20.152 7.246 2.465 1.00 13.32 ? 263 ARG A NH1 1 ATOM 1810 N NH2 . ARG A 1 237 ? -18.001 8.009 2.316 1.00 13.38 ? 263 ARG A NH2 1 ATOM 1811 N N . LYS A 1 238 ? -22.438 3.301 7.307 1.00 14.60 ? 264 LYS A N 1 ATOM 1812 C CA . LYS A 1 238 ? -23.697 2.772 7.796 1.00 14.77 ? 264 LYS A CA 1 ATOM 1813 C C . LYS A 1 238 ? -24.768 2.988 6.736 1.00 14.89 ? 264 LYS A C 1 ATOM 1814 O O . LYS A 1 238 ? -24.580 3.777 5.813 1.00 15.02 ? 264 LYS A O 1 ATOM 1815 C CB . LYS A 1 238 ? -24.042 3.436 9.130 1.00 14.75 ? 264 LYS A CB 1 ATOM 1816 C CG . LYS A 1 238 ? -22.816 3.536 10.030 1.00 14.71 ? 264 LYS A CG 1 ATOM 1817 C CD . LYS A 1 238 ? -23.125 3.341 11.498 1.00 14.66 ? 264 LYS A CD 1 ATOM 1818 C CE . LYS A 1 238 ? -21.855 3.437 12.329 1.00 14.73 ? 264 LYS A CE 1 ATOM 1819 N NZ . LYS A 1 238 ? -21.991 2.737 13.637 1.00 14.83 ? 264 LYS A NZ 1 ATOM 1820 N N . GLY A 1 239 ? -25.879 2.271 6.859 1.00 15.06 ? 265 GLY A N 1 ATOM 1821 C CA . GLY A 1 239 ? -26.823 2.131 5.758 1.00 15.33 ? 265 GLY A CA 1 ATOM 1822 C C . GLY A 1 239 ? -27.970 3.120 5.665 1.00 15.70 ? 265 GLY A C 1 ATOM 1823 O O . GLY A 1 239 ? -28.671 3.147 4.651 1.00 16.25 ? 265 GLY A O 1 ATOM 1824 N N . ALA A 1 240 ? -28.185 3.922 6.707 1.00 15.84 ? 266 ALA A N 1 ATOM 1825 C CA . ALA A 1 240 ? -29.404 4.732 6.815 1.00 15.84 ? 266 ALA A CA 1 ATOM 1826 C C . ALA A 1 240 ? -30.628 3.895 6.428 1.00 15.61 ? 266 ALA A C 1 ATOM 1827 O O . ALA A 1 240 ? -31.425 4.303 5.596 1.00 15.60 ? 266 ALA A O 1 ATOM 1828 C CB . ALA A 1 240 ? -29.301 5.985 5.953 1.00 15.80 ? 266 ALA A CB 1 ATOM 1829 N N . ARG A 1 241 ? -30.734 2.709 7.033 1.00 15.67 ? 267 ARG A N 1 ATOM 1830 C CA . ARG A 1 241 ? -31.858 1.768 6.847 1.00 15.38 ? 267 ARG A CA 1 ATOM 1831 C C . ARG A 1 241 ? -31.844 0.961 5.538 1.00 15.16 ? 267 ARG A C 1 ATOM 1832 O O . ARG A 1 241 ? -32.724 0.128 5.313 1.00 15.33 ? 267 ARG A O 1 ATOM 1833 C CB . ARG A 1 241 ? -33.211 2.466 7.043 1.00 15.51 ? 267 ARG A CB 1 ATOM 1834 C CG . ARG A 1 241 ? -33.347 3.137 8.401 1.00 15.69 ? 267 ARG A CG 1 ATOM 1835 C CD . ARG A 1 241 ? -34.776 3.588 8.669 1.00 15.82 ? 267 ARG A CD 1 ATOM 1836 N NE . ARG A 1 241 ? -34.965 4.053 10.040 1.00 15.66 ? 267 ARG A NE 1 ATOM 1837 C CZ . ARG A 1 241 ? -34.561 5.233 10.509 1.00 15.94 ? 267 ARG A CZ 1 ATOM 1838 N NH1 . ARG A 1 241 ? -33.923 6.096 9.728 1.00 16.24 ? 267 ARG A NH1 1 ATOM 1839 N NH2 . ARG A 1 241 ? -34.790 5.556 11.775 1.00 15.79 ? 267 ARG A NH2 1 ATOM 1840 N N . SER A 1 242 ? -30.837 1.176 4.700 1.00 14.96 ? 268 SER A N 1 ATOM 1841 C CA . SER A 1 242 ? -30.693 0.439 3.448 1.00 14.78 ? 268 SER A CA 1 ATOM 1842 C C . SER A 1 242 ? -29.525 -0.538 3.566 1.00 14.50 ? 268 SER A C 1 ATOM 1843 O O . SER A 1 242 ? -28.422 -0.150 3.943 1.00 14.22 ? 268 SER A O 1 ATOM 1844 C CB . SER A 1 242 ? -30.461 1.402 2.282 1.00 14.89 ? 268 SER A CB 1 ATOM 1845 O OG . SER A 1 242 ? -29.959 0.715 1.144 1.00 15.30 ? 268 SER A OG 1 ATOM 1846 N N . SER A 1 243 ? -29.769 -1.803 3.234 1.00 14.27 ? 269 SER A N 1 ATOM 1847 C CA . SER A 1 243 ? -28.717 -2.815 3.285 1.00 14.31 ? 269 SER A CA 1 ATOM 1848 C C . SER A 1 243 ? -27.685 -2.585 2.184 1.00 14.14 ? 269 SER A C 1 ATOM 1849 O O . SER A 1 243 ? -26.485 -2.518 2.457 1.00 13.95 ? 269 SER A O 1 ATOM 1850 C CB . SER A 1 243 ? -29.305 -4.223 3.165 1.00 14.36 ? 269 SER A CB 1 ATOM 1851 O OG . SER A 1 243 ? -30.124 -4.332 2.016 1.00 14.53 ? 269 SER A OG 1 ATOM 1852 N N . ILE A 1 244 ? -28.158 -2.456 0.945 1.00 14.01 ? 270 ILE A N 1 ATOM 1853 C CA . ILE A 1 244 ? -27.270 -2.353 -0.212 1.00 14.13 ? 270 ILE A CA 1 ATOM 1854 C C . ILE A 1 244 ? -26.468 -1.045 -0.212 1.00 14.40 ? 270 ILE A C 1 ATOM 1855 O O . ILE A 1 244 ? -25.373 -0.975 -0.773 1.00 14.49 ? 270 ILE A O 1 ATOM 1856 C CB . ILE A 1 244 ? -28.055 -2.510 -1.541 1.00 13.99 ? 270 ILE A CB 1 ATOM 1857 C CG1 . ILE A 1 244 ? -27.112 -2.906 -2.684 1.00 13.87 ? 270 ILE A CG1 1 ATOM 1858 C CG2 . ILE A 1 244 ? -28.850 -1.248 -1.879 1.00 13.84 ? 270 ILE A CG2 1 ATOM 1859 C CD1 . ILE A 1 244 ? -26.668 -4.351 -2.634 1.00 13.91 ? 270 ILE A CD1 1 ATOM 1860 N N . SER A 1 245 ? -27.017 -0.015 0.421 1.00 14.64 ? 271 SER A N 1 ATOM 1861 C CA . SER A 1 245 ? -26.327 1.257 0.565 1.00 15.12 ? 271 SER A CA 1 ATOM 1862 C C . SER A 1 245 ? -24.941 1.108 1.203 1.00 15.15 ? 271 SER A C 1 ATOM 1863 O O . SER A 1 245 ? -24.018 1.853 0.883 1.00 14.97 ? 271 SER A O 1 ATOM 1864 C CB . SER A 1 245 ? -27.170 2.197 1.413 1.00 15.21 ? 271 SER A CB 1 ATOM 1865 O OG . SER A 1 245 ? -26.466 3.386 1.667 1.00 16.20 ? 271 SER A OG 1 ATOM 1866 N N . ILE A 1 246 ? -24.807 0.155 2.120 1.00 15.31 ? 272 ILE A N 1 ATOM 1867 C CA . ILE A 1 246 ? -23.552 -0.037 2.833 1.00 15.40 ? 272 ILE A CA 1 ATOM 1868 C C . ILE A 1 246 ? -22.470 -0.435 1.838 1.00 15.67 ? 272 ILE A C 1 ATOM 1869 O O . ILE A 1 246 ? -21.403 0.183 1.797 1.00 15.71 ? 272 ILE A O 1 ATOM 1870 C CB . ILE A 1 246 ? -23.699 -1.071 3.967 1.00 15.25 ? 272 ILE A CB 1 ATOM 1871 C CG1 . ILE A 1 246 ? -24.626 -0.508 5.049 1.00 15.26 ? 272 ILE A CG1 1 ATOM 1872 C CG2 . ILE A 1 246 ? -22.341 -1.403 4.579 1.00 15.43 ? 272 ILE A CG2 1 ATOM 1873 C CD1 . ILE A 1 246 ? -25.113 -1.536 6.045 1.00 15.32 ? 272 ILE A CD1 1 ATOM 1874 N N . LEU A 1 247 ? -22.772 -1.442 1.022 1.00 15.81 ? 273 LEU A N 1 ATOM 1875 C CA . LEU A 1 247 ? -21.851 -1.929 0.003 1.00 15.92 ? 273 LEU A CA 1 ATOM 1876 C C . LEU A 1 247 ? -21.543 -0.855 -1.035 1.00 15.86 ? 273 LEU A C 1 ATOM 1877 O O . LEU A 1 247 ? -20.393 -0.700 -1.443 1.00 15.57 ? 273 LEU A O 1 ATOM 1878 C CB . LEU A 1 247 ? -22.434 -3.168 -0.681 1.00 16.22 ? 273 LEU A CB 1 ATOM 1879 C CG . LEU A 1 247 ? -21.640 -3.780 -1.836 1.00 16.50 ? 273 LEU A CG 1 ATOM 1880 C CD1 . LEU A 1 247 ? -20.212 -4.106 -1.424 1.00 16.79 ? 273 LEU A CD1 1 ATOM 1881 C CD2 . LEU A 1 247 ? -22.347 -5.031 -2.322 1.00 16.63 ? 273 LEU A CD2 1 ATOM 1882 N N . GLU A 1 248 ? -22.569 -0.117 -1.451 1.00 15.68 ? 274 GLU A N 1 ATOM 1883 C CA . GLU A 1 248 ? -22.403 0.932 -2.458 1.00 16.02 ? 274 GLU A CA 1 ATOM 1884 C C . GLU A 1 248 ? -21.429 1.996 -1.984 1.00 15.63 ? 274 GLU A C 1 ATOM 1885 O O . GLU A 1 248 ? -20.522 2.374 -2.720 1.00 15.54 ? 274 GLU A O 1 ATOM 1886 C CB . GLU A 1 248 ? -23.745 1.571 -2.824 1.00 16.35 ? 274 GLU A CB 1 ATOM 1887 C CG . GLU A 1 248 ? -24.666 0.631 -3.597 1.00 16.69 ? 274 GLU A CG 1 ATOM 1888 C CD . GLU A 1 248 ? -26.073 1.174 -3.772 1.00 16.98 ? 274 GLU A CD 1 ATOM 1889 O OE1 . GLU A 1 248 ? -26.470 2.098 -3.029 1.00 17.54 ? 274 GLU A OE1 1 ATOM 1890 O OE2 . GLU A 1 248 ? -26.791 0.675 -4.660 1.00 17.32 ? 274 GLU A OE2 1 ATOM 1891 N N . GLN A 1 249 ? -21.607 2.460 -0.750 1.00 15.43 ? 275 GLN A N 1 ATOM 1892 C CA . GLN A 1 249 ? -20.690 3.437 -0.157 1.00 15.25 ? 275 GLN A CA 1 ATOM 1893 C C . GLN A 1 249 ? -19.265 2.896 -0.042 1.00 15.27 ? 275 GLN A C 1 ATOM 1894 O O . GLN A 1 249 ? -18.305 3.607 -0.325 1.00 15.26 ? 275 GLN A O 1 ATOM 1895 C CB . GLN A 1 249 ? -21.180 3.866 1.222 1.00 15.26 ? 275 GLN A CB 1 ATOM 1896 C CG . GLN A 1 249 ? -22.441 4.703 1.187 1.00 15.22 ? 275 GLN A CG 1 ATOM 1897 C CD . GLN A 1 249 ? -22.978 4.967 2.574 1.00 15.15 ? 275 GLN A CD 1 ATOM 1898 O OE1 . GLN A 1 249 ? -22.447 5.804 3.300 1.00 15.14 ? 275 GLN A OE1 1 ATOM 1899 N NE2 . GLN A 1 249 ? -24.033 4.259 2.950 1.00 15.11 ? 275 GLN A NE2 1 ATOM 1900 N N . GLU A 1 250 ? -19.129 1.641 0.372 1.00 15.21 ? 276 GLU A N 1 ATOM 1901 C CA . GLU A 1 250 ? -17.804 1.017 0.485 1.00 15.22 ? 276 GLU A CA 1 ATOM 1902 C C . GLU A 1 250 ? -17.053 0.984 -0.845 1.00 15.22 ? 276 GLU A C 1 ATOM 1903 O O . GLU A 1 250 ? -15.864 1.283 -0.885 1.00 14.88 ? 276 GLU A O 1 ATOM 1904 C CB . GLU A 1 250 ? -17.923 -0.406 1.017 1.00 15.11 ? 276 GLU A CB 1 ATOM 1905 C CG . GLU A 1 250 ? -18.290 -0.486 2.482 1.00 15.28 ? 276 GLU A CG 1 ATOM 1906 C CD . GLU A 1 250 ? -18.729 -1.876 2.883 1.00 15.36 ? 276 GLU A CD 1 ATOM 1907 O OE1 . GLU A 1 250 ? -19.100 -2.668 1.988 1.00 15.42 ? 276 GLU A OE1 1 ATOM 1908 O OE2 . GLU A 1 250 ? -18.701 -2.184 4.090 1.00 15.26 ? 276 GLU A OE2 1 ATOM 1909 N N . LYS A 1 251 ? -17.754 0.616 -1.919 1.00 15.64 ? 277 LYS A N 1 ATOM 1910 C CA . LYS A 1 251 ? -17.152 0.534 -3.249 1.00 16.22 ? 277 LYS A CA 1 ATOM 1911 C C . LYS A 1 251 ? -16.655 1.896 -3.739 1.00 16.09 ? 277 LYS A C 1 ATOM 1912 O O . LYS A 1 251 ? -15.590 1.987 -4.348 1.00 15.64 ? 277 LYS A O 1 ATOM 1913 C CB . LYS A 1 251 ? -18.135 -0.053 -4.268 1.00 16.94 ? 277 LYS A CB 1 ATOM 1914 C CG . LYS A 1 251 ? -18.564 -1.487 -3.973 1.00 17.77 ? 277 LYS A CG 1 ATOM 1915 C CD . LYS A 1 251 ? -18.934 -2.263 -5.229 1.00 18.38 ? 277 LYS A CD 1 ATOM 1916 C CE . LYS A 1 251 ? -20.078 -1.599 -5.973 1.00 19.06 ? 277 LYS A CE 1 ATOM 1917 N NZ . LYS A 1 251 ? -20.610 -2.481 -7.049 1.00 19.85 ? 277 LYS A NZ 1 ATOM 1918 N N . VAL A 1 252 ? -17.425 2.947 -3.464 1.00 15.91 ? 278 VAL A N 1 ATOM 1919 C CA . VAL A 1 252 ? -17.017 4.302 -3.810 1.00 16.04 ? 278 VAL A CA 1 ATOM 1920 C C . VAL A 1 252 ? -15.719 4.665 -3.090 1.00 16.02 ? 278 VAL A C 1 ATOM 1921 O O . VAL A 1 252 ? -14.760 5.122 -3.719 1.00 15.90 ? 278 VAL A O 1 ATOM 1922 C CB . VAL A 1 252 ? -18.105 5.338 -3.456 1.00 16.30 ? 278 VAL A CB 1 ATOM 1923 C CG1 . VAL A 1 252 ? -17.601 6.754 -3.715 1.00 16.27 ? 278 VAL A CG1 1 ATOM 1924 C CG2 . VAL A 1 252 ? -19.371 5.072 -4.260 1.00 16.48 ? 278 VAL A CG2 1 ATOM 1925 N N . VAL A 1 253 ? -15.689 4.452 -1.777 1.00 15.81 ? 279 VAL A N 1 ATOM 1926 C CA . VAL A 1 253 ? -14.508 4.785 -0.974 1.00 15.80 ? 279 VAL A CA 1 ATOM 1927 C C . VAL A 1 253 ? -13.299 3.912 -1.325 1.00 15.92 ? 279 VAL A C 1 ATOM 1928 O O . VAL A 1 253 ? -12.192 4.425 -1.472 1.00 15.97 ? 279 VAL A O 1 ATOM 1929 C CB . VAL A 1 253 ? -14.799 4.687 0.539 1.00 15.58 ? 279 VAL A CB 1 ATOM 1930 C CG1 . VAL A 1 253 ? -13.519 4.873 1.348 1.00 15.65 ? 279 VAL A CG1 1 ATOM 1931 C CG2 . VAL A 1 253 ? -15.837 5.727 0.949 1.00 15.55 ? 279 VAL A CG2 1 ATOM 1932 N N . ALA A 1 254 ? -13.513 2.603 -1.450 1.00 16.21 ? 280 ALA A N 1 ATOM 1933 C CA . ALA A 1 254 ? -12.438 1.662 -1.806 1.00 16.49 ? 280 ALA A CA 1 ATOM 1934 C C . ALA A 1 254 ? -11.796 1.989 -3.162 1.00 17.05 ? 280 ALA A C 1 ATOM 1935 O O . ALA A 1 254 ? -10.585 1.827 -3.350 1.00 16.70 ? 280 ALA A O 1 ATOM 1936 C CB . ALA A 1 254 ? -12.969 0.239 -1.817 1.00 16.15 ? 280 ALA A CB 1 ATOM 1937 N N . GLN A 1 255 ? -12.622 2.429 -4.104 1.00 17.60 ? 281 GLN A N 1 ATOM 1938 C CA . GLN A 1 255 ? -12.156 2.813 -5.428 1.00 18.68 ? 281 GLN A CA 1 ATOM 1939 C C . GLN A 1 255 ? -11.305 4.082 -5.330 1.00 18.45 ? 281 GLN A C 1 ATOM 1940 O O . GLN A 1 255 ? -10.215 4.145 -5.891 1.00 17.74 ? 281 GLN A O 1 ATOM 1941 C CB . GLN A 1 255 ? -13.364 3.013 -6.358 1.00 19.67 ? 281 GLN A CB 1 ATOM 1942 C CG . GLN A 1 255 ? -13.074 3.496 -7.771 1.00 20.77 ? 281 GLN A CG 1 ATOM 1943 C CD . GLN A 1 255 ? -12.134 2.614 -8.580 1.00 22.19 ? 281 GLN A CD 1 ATOM 1944 O OE1 . GLN A 1 255 ? -11.609 3.055 -9.606 1.00 24.63 ? 281 GLN A OE1 1 ATOM 1945 N NE2 . GLN A 1 255 ? -11.924 1.376 -8.148 1.00 22.87 ? 281 GLN A NE2 1 ATOM 1946 N N . GLN A 1 256 ? -11.799 5.078 -4.602 1.00 18.74 ? 282 GLN A N 1 ATOM 1947 C CA . GLN A 1 256 ? -11.037 6.306 -4.365 1.00 19.73 ? 282 GLN A CA 1 ATOM 1948 C C . GLN A 1 256 ? -9.669 6.023 -3.752 1.00 19.76 ? 282 GLN A C 1 ATOM 1949 O O . GLN A 1 256 ? -8.656 6.563 -4.200 1.00 19.48 ? 282 GLN A O 1 ATOM 1950 C CB . GLN A 1 256 ? -11.816 7.252 -3.458 1.00 20.33 ? 282 GLN A CB 1 ATOM 1951 C CG . GLN A 1 256 ? -12.971 7.935 -4.165 1.00 21.14 ? 282 GLN A CG 1 ATOM 1952 C CD . GLN A 1 256 ? -13.907 8.631 -3.210 1.00 21.96 ? 282 GLN A CD 1 ATOM 1953 O OE1 . GLN A 1 256 ? -13.798 8.484 -1.992 1.00 23.59 ? 282 GLN A OE1 1 ATOM 1954 N NE2 . GLN A 1 256 ? -14.846 9.383 -3.757 1.00 22.68 ? 282 GLN A NE2 1 ATOM 1955 N N . ILE A 1 257 ? -9.654 5.169 -2.734 1.00 19.99 ? 283 ILE A N 1 ATOM 1956 C CA . ILE A 1 257 ? -8.414 4.766 -2.067 1.00 20.69 ? 283 ILE A CA 1 ATOM 1957 C C . ILE A 1 257 ? -7.444 4.096 -3.042 1.00 21.16 ? 283 ILE A C 1 ATOM 1958 O O . ILE A 1 257 ? -6.283 4.477 -3.118 1.00 20.46 ? 283 ILE A O 1 ATOM 1959 C CB . ILE A 1 257 ? -8.704 3.824 -0.874 1.00 20.41 ? 283 ILE A CB 1 ATOM 1960 C CG1 . ILE A 1 257 ? -9.329 4.625 0.273 1.00 20.25 ? 283 ILE A CG1 1 ATOM 1961 C CG2 . ILE A 1 257 ? -7.430 3.129 -0.404 1.00 20.59 ? 283 ILE A CG2 1 ATOM 1962 C CD1 . ILE A 1 257 ? -9.966 3.778 1.351 1.00 20.30 ? 283 ILE A CD1 1 ATOM 1963 N N . ARG A 1 258 ? -7.940 3.099 -3.769 1.00 22.51 ? 284 ARG A N 1 ATOM 1964 C CA . ARG A 1 258 ? -7.146 2.340 -4.740 1.00 23.99 ? 284 ARG A CA 1 ATOM 1965 C C . ARG A 1 258 ? -6.489 3.238 -5.798 1.00 23.33 ? 284 ARG A C 1 ATOM 1966 O O . ARG A 1 258 ? -5.336 3.025 -6.176 1.00 22.79 ? 284 ARG A O 1 ATOM 1967 C CB . ARG A 1 258 ? -8.039 1.292 -5.425 1.00 25.85 ? 284 ARG A CB 1 ATOM 1968 C CG . ARG A 1 258 ? -7.404 0.571 -6.603 1.00 28.27 ? 284 ARG A CG 1 ATOM 1969 C CD . ARG A 1 258 ? -8.429 -0.235 -7.392 1.00 30.23 ? 284 ARG A CD 1 ATOM 1970 N NE . ARG A 1 258 ? -8.825 -1.457 -6.699 1.00 31.88 ? 284 ARG A NE 1 ATOM 1971 C CZ . ARG A 1 258 ? -9.527 -2.453 -7.243 1.00 34.25 ? 284 ARG A CZ 1 ATOM 1972 N NH1 . ARG A 1 258 ? -9.939 -2.401 -8.511 1.00 34.28 ? 284 ARG A NH1 1 ATOM 1973 N NH2 . ARG A 1 258 ? -9.821 -3.520 -6.508 1.00 34.90 ? 284 ARG A NH2 1 ATOM 1974 N N . GLN A 1 259 ? -7.233 4.234 -6.265 1.00 22.79 ? 285 GLN A N 1 ATOM 1975 C CA . GLN A 1 259 ? -6.799 5.080 -7.372 1.00 22.47 ? 285 GLN A CA 1 ATOM 1976 C C . GLN A 1 259 ? -5.921 6.240 -6.929 1.00 20.95 ? 285 GLN A C 1 ATOM 1977 O O . GLN A 1 259 ? -4.965 6.583 -7.618 1.00 20.23 ? 285 GLN A O 1 ATOM 1978 C CB . GLN A 1 259 ? -8.010 5.625 -8.122 1.00 23.38 ? 285 GLN A CB 1 ATOM 1979 C CG . GLN A 1 259 ? -8.726 4.578 -8.952 1.00 24.52 ? 285 GLN A CG 1 ATOM 1980 C CD . GLN A 1 259 ? -9.646 5.201 -9.974 1.00 25.91 ? 285 GLN A CD 1 ATOM 1981 O OE1 . GLN A 1 259 ? -10.549 5.959 -9.625 1.00 27.08 ? 285 GLN A OE1 1 ATOM 1982 N NE2 . GLN A 1 259 ? -9.423 4.889 -11.247 1.00 27.36 ? 285 GLN A NE2 1 ATOM 1983 N N . LEU A 1 260 ? -6.262 6.854 -5.799 1.00 19.57 ? 286 LEU A N 1 ATOM 1984 C CA . LEU A 1 260 ? -5.490 7.980 -5.271 1.00 18.59 ? 286 LEU A CA 1 ATOM 1985 C C . LEU A 1 260 ? -4.283 7.526 -4.466 1.00 17.29 ? 286 LEU A C 1 ATOM 1986 O O . LEU A 1 260 ? -3.323 8.273 -4.335 1.00 17.23 ? 286 LEU A O 1 ATOM 1987 C CB . LEU A 1 260 ? -6.368 8.884 -4.405 1.00 18.77 ? 286 LEU A CB 1 ATOM 1988 C CG . LEU A 1 260 ? -7.516 9.600 -5.124 1.00 19.30 ? 286 LEU A CG 1 ATOM 1989 C CD1 . LEU A 1 260 ? -8.419 10.295 -4.111 1.00 19.37 ? 286 LEU A CD1 1 ATOM 1990 C CD2 . LEU A 1 260 ? -6.986 10.603 -6.141 1.00 19.15 ? 286 LEU A CD2 1 ATOM 1991 N N . PHE A 1 261 ? -4.342 6.318 -3.912 1.00 16.46 ? 287 PHE A N 1 ATOM 1992 C CA . PHE A 1 261 ? -3.248 5.771 -3.102 1.00 15.72 ? 287 PHE A CA 1 ATOM 1993 C C . PHE A 1 261 ? -2.936 4.339 -3.574 1.00 15.26 ? 287 PHE A C 1 ATOM 1994 O O . PHE A 1 261 ? -3.298 3.370 -2.903 1.00 14.78 ? 287 PHE A O 1 ATOM 1995 C CB . PHE A 1 261 ? -3.623 5.804 -1.612 1.00 15.60 ? 287 PHE A CB 1 ATOM 1996 C CG . PHE A 1 261 ? -4.046 7.162 -1.121 1.00 15.58 ? 287 PHE A CG 1 ATOM 1997 C CD1 . PHE A 1 261 ? -3.102 8.091 -0.702 1.00 15.58 ? 287 PHE A CD1 1 ATOM 1998 C CD2 . PHE A 1 261 ? -5.388 7.515 -1.083 1.00 15.59 ? 287 PHE A CD2 1 ATOM 1999 C CE1 . PHE A 1 261 ? -3.484 9.343 -0.258 1.00 15.25 ? 287 PHE A CE1 1 ATOM 2000 C CE2 . PHE A 1 261 ? -5.777 8.766 -0.642 1.00 15.55 ? 287 PHE A CE2 1 ATOM 2001 C CZ . PHE A 1 261 ? -4.822 9.683 -0.229 1.00 15.47 ? 287 PHE A CZ 1 ATOM 2002 N N . PRO A 1 262 ? -2.249 4.205 -4.731 1.00 14.96 ? 288 PRO A N 1 ATOM 2003 C CA . PRO A 1 262 ? -2.056 2.902 -5.385 1.00 15.00 ? 288 PRO A CA 1 ATOM 2004 C C . PRO A 1 262 ? -1.246 1.870 -4.587 1.00 15.04 ? 288 PRO A C 1 ATOM 2005 O O . PRO A 1 262 ? -1.341 0.677 -4.865 1.00 15.43 ? 288 PRO A O 1 ATOM 2006 C CB . PRO A 1 262 ? -1.358 3.264 -6.712 1.00 15.00 ? 288 PRO A CB 1 ATOM 2007 C CG . PRO A 1 262 ? -0.715 4.584 -6.459 1.00 14.90 ? 288 PRO A CG 1 ATOM 2008 C CD . PRO A 1 262 ? -1.637 5.296 -5.510 1.00 14.89 ? 288 PRO A CD 1 ATOM 2009 N N . LYS A 1 263 ? -0.476 2.310 -3.600 1.00 14.81 ? 289 LYS A N 1 ATOM 2010 C CA . LYS A 1 263 ? 0.214 1.379 -2.712 1.00 14.79 ? 289 LYS A CA 1 ATOM 2011 C C . LYS A 1 263 ? -0.774 0.573 -1.883 1.00 14.66 ? 289 LYS A C 1 ATOM 2012 O O . LYS A 1 263 ? -0.451 -0.521 -1.425 1.00 14.86 ? 289 LYS A O 1 ATOM 2013 C CB . LYS A 1 263 ? 1.170 2.114 -1.770 1.00 14.87 ? 289 LYS A CB 1 ATOM 2014 C CG . LYS A 1 263 ? 2.340 2.782 -2.465 1.00 14.93 ? 289 LYS A CG 1 ATOM 2015 C CD . LYS A 1 263 ? 3.142 3.632 -1.501 1.00 15.06 ? 289 LYS A CD 1 ATOM 2016 C CE . LYS A 1 263 ? 4.332 4.272 -2.200 1.00 15.02 ? 289 LYS A CE 1 ATOM 2017 N NZ . LYS A 1 263 ? 5.143 5.049 -1.228 1.00 15.03 ? 289 LYS A NZ 1 ATOM 2018 N N . PHE A 1 264 ? -1.974 1.107 -1.689 1.00 14.38 ? 290 PHE A N 1 ATOM 2019 C CA . PHE A 1 264 ? -2.987 0.417 -0.900 1.00 14.34 ? 290 PHE A CA 1 ATOM 2020 C C . PHE A 1 264 ? -3.974 -0.416 -1.729 1.00 14.24 ? 290 PHE A C 1 ATOM 2021 O O . PHE A 1 264 ? -5.032 -0.773 -1.234 1.00 14.37 ? 290 PHE A O 1 ATOM 2022 C CB . PHE A 1 264 ? -3.744 1.426 -0.033 1.00 14.29 ? 290 PHE A CB 1 ATOM 2023 C CG . PHE A 1 264 ? -2.847 2.304 0.808 1.00 14.42 ? 290 PHE A CG 1 ATOM 2024 C CD1 . PHE A 1 264 ? -1.698 1.799 1.400 1.00 14.44 ? 290 PHE A CD1 1 ATOM 2025 C CD2 . PHE A 1 264 ? -3.175 3.635 1.032 1.00 14.53 ? 290 PHE A CD2 1 ATOM 2026 C CE1 . PHE A 1 264 ? -0.888 2.603 2.180 1.00 14.50 ? 290 PHE A CE1 1 ATOM 2027 C CE2 . PHE A 1 264 ? -2.370 4.443 1.817 1.00 14.59 ? 290 PHE A CE2 1 ATOM 2028 C CZ . PHE A 1 264 ? -1.223 3.926 2.390 1.00 14.62 ? 290 PHE A CZ 1 ATOM 2029 N N . ALA A 1 265 ? -3.616 -0.762 -2.965 1.00 14.16 ? 291 ALA A N 1 ATOM 2030 C CA . ALA A 1 265 ? -4.505 -1.547 -3.831 1.00 14.05 ? 291 ALA A CA 1 ATOM 2031 C C . ALA A 1 265 ? -4.854 -2.922 -3.243 1.00 13.90 ? 291 ALA A C 1 ATOM 2032 O O . ALA A 1 265 ? -5.990 -3.378 -3.366 1.00 13.47 ? 291 ALA A O 1 ATOM 2033 C CB . ALA A 1 265 ? -3.891 -1.701 -5.211 1.00 14.07 ? 291 ALA A CB 1 ATOM 2034 N N . ASP A 1 266 ? -3.881 -3.564 -2.597 1.00 13.90 ? 292 ASP A N 1 ATOM 2035 C CA . ASP A 1 266 ? -4.096 -4.850 -1.928 1.00 13.95 ? 292 ASP A CA 1 ATOM 2036 C C . ASP A 1 266 ? -4.140 -4.739 -0.398 1.00 13.94 ? 292 ASP A C 1 ATOM 2037 O O . ASP A 1 266 ? -4.003 -5.739 0.303 1.00 13.74 ? 292 ASP A O 1 ATOM 2038 C CB . ASP A 1 266 ? -3.003 -5.838 -2.344 1.00 14.09 ? 292 ASP A CB 1 ATOM 2039 C CG . ASP A 1 266 ? -3.155 -6.293 -3.766 1.00 14.18 ? 292 ASP A CG 1 ATOM 2040 O OD1 . ASP A 1 266 ? -4.240 -6.801 -4.101 1.00 14.41 ? 292 ASP A OD1 1 ATOM 2041 O OD2 . ASP A 1 266 ? -2.199 -6.144 -4.556 1.00 14.34 ? 292 ASP A OD2 1 ATOM 2042 N N . THR A 1 267 ? -4.345 -3.528 0.118 1.00 13.94 ? 293 THR A N 1 ATOM 2043 C CA . THR A 1 267 ? -4.415 -3.313 1.557 1.00 13.72 ? 293 THR A CA 1 ATOM 2044 C C . THR A 1 267 ? -5.821 -3.683 2.034 1.00 13.38 ? 293 THR A C 1 ATOM 2045 O O . THR A 1 267 ? -6.798 -3.083 1.587 1.00 13.06 ? 293 THR A O 1 ATOM 2046 C CB . THR A 1 267 ? -4.079 -1.851 1.916 1.00 13.85 ? 293 THR A CB 1 ATOM 2047 O OG1 . THR A 1 267 ? -2.722 -1.577 1.549 1.00 14.13 ? 293 THR A OG1 1 ATOM 2048 C CG2 . THR A 1 267 ? -4.243 -1.591 3.410 1.00 13.84 ? 293 THR A CG2 1 ATOM 2049 N N . PRO A 1 268 ? -5.934 -4.674 2.940 1.00 13.30 ? 294 PRO A N 1 ATOM 2050 C CA . PRO A 1 268 ? -7.269 -5.086 3.361 1.00 13.28 ? 294 PRO A CA 1 ATOM 2051 C C . PRO A 1 268 ? -8.108 -3.936 3.921 1.00 13.53 ? 294 PRO A C 1 ATOM 2052 O O . PRO A 1 268 ? -7.599 -3.063 4.641 1.00 13.39 ? 294 PRO A O 1 ATOM 2053 C CB . PRO A 1 268 ? -6.996 -6.138 4.434 1.00 13.26 ? 294 PRO A CB 1 ATOM 2054 C CG . PRO A 1 268 ? -5.668 -6.697 4.069 1.00 13.24 ? 294 PRO A CG 1 ATOM 2055 C CD . PRO A 1 268 ? -4.892 -5.513 3.560 1.00 13.41 ? 294 PRO A CD 1 ATOM 2056 N N . ILE A 1 269 ? -9.380 -3.940 3.550 1.00 13.56 ? 295 ILE A N 1 ATOM 2057 C CA . ILE A 1 269 ? -10.328 -2.930 3.965 1.00 13.63 ? 295 ILE A CA 1 ATOM 2058 C C . ILE A 1 269 ? -11.272 -3.585 4.960 1.00 13.54 ? 295 ILE A C 1 ATOM 2059 O O . ILE A 1 269 ? -11.768 -4.691 4.727 1.00 13.18 ? 295 ILE A O 1 ATOM 2060 C CB . ILE A 1 269 ? -11.100 -2.375 2.749 1.00 13.85 ? 295 ILE A CB 1 ATOM 2061 C CG1 . ILE A 1 269 ? -10.167 -1.479 1.932 1.00 14.09 ? 295 ILE A CG1 1 ATOM 2062 C CG2 . ILE A 1 269 ? -12.336 -1.594 3.185 1.00 13.94 ? 295 ILE A CG2 1 ATOM 2063 C CD1 . ILE A 1 269 ? -10.686 -1.121 0.559 1.00 14.44 ? 295 ILE A CD1 1 ATOM 2064 N N . TYR A 1 270 ? -11.470 -2.913 6.088 1.00 13.59 ? 296 TYR A N 1 ATOM 2065 C CA . TYR A 1 270 ? -12.444 -3.318 7.092 1.00 13.59 ? 296 TYR A CA 1 ATOM 2066 C C . TYR A 1 270 ? -13.540 -2.270 7.094 1.00 13.54 ? 296 TYR A C 1 ATOM 2067 O O . TYR A 1 270 ? -13.249 -1.071 7.028 1.00 13.78 ? 296 TYR A O 1 ATOM 2068 C CB . TYR A 1 270 ? -11.833 -3.307 8.492 1.00 13.53 ? 296 TYR A CB 1 ATOM 2069 C CG . TYR A 1 270 ? -10.710 -4.284 8.808 1.00 13.58 ? 296 TYR A CG 1 ATOM 2070 C CD1 . TYR A 1 270 ? -10.089 -5.061 7.832 1.00 13.55 ? 296 TYR A CD1 1 ATOM 2071 C CD2 . TYR A 1 270 ? -10.244 -4.392 10.115 1.00 13.57 ? 296 TYR A CD2 1 ATOM 2072 C CE1 . TYR A 1 270 ? -9.062 -5.933 8.160 1.00 13.55 ? 296 TYR A CE1 1 ATOM 2073 C CE2 . TYR A 1 270 ? -9.216 -5.248 10.448 1.00 13.64 ? 296 TYR A CE2 1 ATOM 2074 C CZ . TYR A 1 270 ? -8.628 -6.020 9.474 1.00 13.58 ? 296 TYR A CZ 1 ATOM 2075 O OH . TYR A 1 270 ? -7.607 -6.869 9.833 1.00 13.76 ? 296 TYR A OH 1 ATOM 2076 N N . ASN A 1 271 ? -14.792 -2.705 7.165 1.00 13.43 ? 297 ASN A N 1 ATOM 2077 C CA . ASN A 1 271 ? -15.854 -1.829 7.641 1.00 13.45 ? 297 ASN A CA 1 ATOM 2078 C C . ASN A 1 271 ? -16.209 -2.285 9.045 1.00 13.62 ? 297 ASN A C 1 ATOM 2079 O O . ASN A 1 271 ? -17.039 -3.177 9.216 1.00 13.70 ? 297 ASN A O 1 ATOM 2080 C CB . ASN A 1 271 ? -17.080 -1.857 6.722 1.00 13.17 ? 297 ASN A CB 1 ATOM 2081 C CG . ASN A 1 271 ? -18.133 -0.827 7.122 1.00 12.94 ? 297 ASN A CG 1 ATOM 2082 O OD1 . ASN A 1 271 ? -18.034 -0.194 8.171 1.00 12.59 ? 297 ASN A OD1 1 ATOM 2083 N ND2 . ASN A 1 271 ? -19.152 -0.666 6.289 1.00 12.86 ? 297 ASN A ND2 1 ATOM 2084 N N . ASP A 1 272 ? -15.567 -1.705 10.057 1.00 13.98 ? 298 ASP A N 1 ATOM 2085 C CA . ASP A 1 272 ? -15.786 -2.198 11.421 1.00 14.41 ? 298 ASP A CA 1 ATOM 2086 C C . ASP A 1 272 ? -16.890 -1.479 12.205 1.00 14.46 ? 298 ASP A C 1 ATOM 2087 O O . ASP A 1 272 ? -16.983 -1.622 13.417 1.00 14.56 ? 298 ASP A O 1 ATOM 2088 C CB . ASP A 1 272 ? -14.478 -2.363 12.225 1.00 14.57 ? 298 ASP A CB 1 ATOM 2089 C CG . ASP A 1 272 ? -13.595 -1.143 12.200 1.00 14.70 ? 298 ASP A CG 1 ATOM 2090 O OD1 . ASP A 1 272 ? -14.074 -0.062 11.830 1.00 14.85 ? 298 ASP A OD1 1 ATOM 2091 O OD2 . ASP A 1 272 ? -12.406 -1.279 12.562 1.00 14.95 ? 298 ASP A OD2 1 ATOM 2092 N N . GLU A 1 273 ? -17.728 -0.721 11.499 1.00 14.75 ? 299 GLU A N 1 ATOM 2093 C CA . GLU A 1 273 ? -19.047 -0.306 12.010 1.00 15.01 ? 299 GLU A CA 1 ATOM 2094 C C . GLU A 1 273 ? -20.053 -0.258 10.851 1.00 14.69 ? 299 GLU A C 1 ATOM 2095 O O . GLU A 1 273 ? -20.501 0.814 10.433 1.00 14.92 ? 299 GLU A O 1 ATOM 2096 C CB . GLU A 1 273 ? -18.976 1.044 12.724 1.00 15.35 ? 299 GLU A CB 1 ATOM 2097 C CG . GLU A 1 273 ? -18.249 0.990 14.054 1.00 16.10 ? 299 GLU A CG 1 ATOM 2098 C CD . GLU A 1 273 ? -18.437 2.236 14.899 1.00 16.66 ? 299 GLU A CD 1 ATOM 2099 O OE1 . GLU A 1 273 ? -19.517 2.860 14.820 1.00 17.19 ? 299 GLU A OE1 1 ATOM 2100 O OE2 . GLU A 1 273 ? -17.501 2.580 15.655 1.00 16.98 ? 299 GLU A OE2 1 ATOM 2101 N N . ALA A 1 274 ? -20.397 -1.437 10.344 1.00 14.31 ? 300 ALA A N 1 ATOM 2102 C CA . ALA A 1 274 ? -21.183 -1.580 9.126 1.00 14.24 ? 300 ALA A CA 1 ATOM 2103 C C . ALA A 1 274 ? -22.665 -1.784 9.445 1.00 14.11 ? 300 ALA A C 1 ATOM 2104 O O . ALA A 1 274 ? -23.276 -2.754 9.001 1.00 14.36 ? 300 ALA A O 1 ATOM 2105 C CB . ALA A 1 274 ? -20.653 -2.756 8.320 1.00 14.12 ? 300 ALA A CB 1 ATOM 2106 N N . ASP A 1 275 ? -23.237 -0.862 10.210 1.00 13.80 ? 301 ASP A N 1 ATOM 2107 C CA . ASP A 1 275 ? -24.576 -1.045 10.770 1.00 13.73 ? 301 ASP A CA 1 ATOM 2108 C C . ASP A 1 275 ? -25.658 -0.511 9.845 1.00 13.58 ? 301 ASP A C 1 ATOM 2109 O O . ASP A 1 275 ? -25.425 0.440 9.098 1.00 13.40 ? 301 ASP A O 1 ATOM 2110 C CB . ASP A 1 275 ? -24.682 -0.347 12.122 1.00 13.77 ? 301 ASP A CB 1 ATOM 2111 C CG . ASP A 1 275 ? -23.568 -0.743 13.064 1.00 13.73 ? 301 ASP A CG 1 ATOM 2112 O OD1 . ASP A 1 275 ? -23.543 -1.916 13.483 1.00 13.66 ? 301 ASP A OD1 1 ATOM 2113 O OD2 . ASP A 1 275 ? -22.723 0.116 13.385 1.00 13.77 ? 301 ASP A OD2 1 ATOM 2114 N N . PRO A 1 276 ? -26.852 -1.126 9.887 1.00 13.68 ? 302 PRO A N 1 ATOM 2115 C CA . PRO A 1 276 ? -28.011 -0.597 9.174 1.00 13.64 ? 302 PRO A CA 1 ATOM 2116 C C . PRO A 1 276 ? -28.266 0.895 9.406 1.00 13.77 ? 302 PRO A C 1 ATOM 2117 O O . PRO A 1 276 ? -28.593 1.612 8.460 1.00 14.35 ? 302 PRO A O 1 ATOM 2118 C CB . PRO A 1 276 ? -29.157 -1.432 9.735 1.00 13.63 ? 302 PRO A CB 1 ATOM 2119 C CG . PRO A 1 276 ? -28.531 -2.756 10.018 1.00 13.56 ? 302 PRO A CG 1 ATOM 2120 C CD . PRO A 1 276 ? -27.128 -2.461 10.459 1.00 13.66 ? 302 PRO A CD 1 ATOM 2121 N N . LEU A 1 277 ? -28.106 1.358 10.644 1.00 13.86 ? 303 LEU A N 1 ATOM 2122 C CA . LEU A 1 277 ? -28.429 2.739 11.004 1.00 13.90 ? 303 LEU A CA 1 ATOM 2123 C C . LEU A 1 277 ? -27.512 3.272 12.107 1.00 14.10 ? 303 LEU A C 1 ATOM 2124 O O . LEU A 1 277 ? -27.280 2.605 13.119 1.00 14.26 ? 303 LEU A O 1 ATOM 2125 C CB . LEU A 1 277 ? -29.891 2.811 11.456 1.00 13.96 ? 303 LEU A CB 1 ATOM 2126 C CG . LEU A 1 277 ? -30.460 4.170 11.881 1.00 13.90 ? 303 LEU A CG 1 ATOM 2127 C CD1 . LEU A 1 277 ? -30.485 5.142 10.711 1.00 13.90 ? 303 LEU A CD1 1 ATOM 2128 C CD2 . LEU A 1 277 ? -31.850 3.996 12.486 1.00 13.82 ? 303 LEU A CD2 1 ATOM 2129 N N . VAL A 1 278 ? -26.982 4.474 11.899 1.00 14.25 ? 304 VAL A N 1 ATOM 2130 C CA . VAL A 1 278 ? -26.178 5.166 12.913 1.00 14.38 ? 304 VAL A CA 1 ATOM 2131 C C . VAL A 1 278 ? -27.002 5.430 14.178 1.00 14.41 ? 304 VAL A C 1 ATOM 2132 O O . VAL A 1 278 ? -28.210 5.626 14.096 1.00 14.94 ? 304 VAL A O 1 ATOM 2133 C CB . VAL A 1 278 ? -25.606 6.501 12.364 1.00 14.62 ? 304 VAL A CB 1 ATOM 2134 C CG1 . VAL A 1 278 ? -26.723 7.493 12.042 1.00 14.68 ? 304 VAL A CG1 1 ATOM 2135 C CG2 . VAL A 1 278 ? -24.609 7.111 13.343 1.00 14.55 ? 304 VAL A CG2 1 ATOM 2136 N N . GLY A 1 279 ? -26.347 5.404 15.341 1.00 14.34 ? 305 GLY A N 1 ATOM 2137 C CA . GLY A 1 279 ? -26.995 5.700 16.619 1.00 13.97 ? 305 GLY A CA 1 ATOM 2138 C C . GLY A 1 279 ? -27.501 4.455 17.327 1.00 14.08 ? 305 GLY A C 1 ATOM 2139 O O . GLY A 1 279 ? -28.687 4.135 17.266 1.00 13.78 ? 305 GLY A O 1 ATOM 2140 N N . TRP A 1 280 ? -26.601 3.770 18.027 1.00 14.13 ? 306 TRP A N 1 ATOM 2141 C CA . TRP A 1 280 ? -26.912 2.470 18.621 1.00 14.30 ? 306 TRP A CA 1 ATOM 2142 C C . TRP A 1 280 ? -28.059 2.540 19.636 1.00 14.25 ? 306 TRP A C 1 ATOM 2143 O O . TRP A 1 280 ? -28.816 1.576 19.771 1.00 13.99 ? 306 TRP A O 1 ATOM 2144 C CB . TRP A 1 280 ? -25.665 1.856 19.281 1.00 14.35 ? 306 TRP A CB 1 ATOM 2145 C CG . TRP A 1 280 ? -25.356 2.427 20.628 1.00 14.36 ? 306 TRP A CG 1 ATOM 2146 C CD1 . TRP A 1 280 ? -24.547 3.487 20.900 1.00 14.39 ? 306 TRP A CD1 1 ATOM 2147 C CD2 . TRP A 1 280 ? -25.874 1.980 21.889 1.00 14.47 ? 306 TRP A CD2 1 ATOM 2148 N NE1 . TRP A 1 280 ? -24.522 3.725 22.254 1.00 14.63 ? 306 TRP A NE1 1 ATOM 2149 C CE2 . TRP A 1 280 ? -25.331 2.817 22.884 1.00 14.53 ? 306 TRP A CE2 1 ATOM 2150 C CE3 . TRP A 1 280 ? -26.748 0.955 22.271 1.00 14.67 ? 306 TRP A CE3 1 ATOM 2151 C CZ2 . TRP A 1 280 ? -25.624 2.659 24.242 1.00 14.78 ? 306 TRP A CZ2 1 ATOM 2152 C CZ3 . TRP A 1 280 ? -27.039 0.794 23.628 1.00 14.85 ? 306 TRP A CZ3 1 ATOM 2153 C CH2 . TRP A 1 280 ? -26.482 1.643 24.592 1.00 14.79 ? 306 TRP A CH2 1 ATOM 2154 N N . SER A 1 281 ? -28.168 3.667 20.346 1.00 14.05 ? 307 SER A N 1 ATOM 2155 C CA . SER A 1 281 ? -29.104 3.800 21.468 1.00 14.29 ? 307 SER A CA 1 ATOM 2156 C C . SER A 1 281 ? -30.500 4.247 21.045 1.00 14.46 ? 307 SER A C 1 ATOM 2157 O O . SER A 1 281 ? -31.438 4.185 21.839 1.00 14.44 ? 307 SER A O 1 ATOM 2158 C CB . SER A 1 281 ? -28.550 4.767 22.518 1.00 14.45 ? 307 SER A CB 1 ATOM 2159 O OG . SER A 1 281 ? -28.530 6.101 22.038 1.00 14.56 ? 307 SER A OG 1 ATOM 2160 N N . LEU A 1 282 ? -30.631 4.712 19.806 1.00 14.69 ? 308 LEU A N 1 ATOM 2161 C CA . LEU A 1 282 ? -31.925 5.084 19.259 1.00 14.84 ? 308 LEU A CA 1 ATOM 2162 C C . LEU A 1 282 ? -32.844 3.862 19.219 1.00 14.73 ? 308 LEU A C 1 ATOM 2163 O O . LEU A 1 282 ? -32.540 2.882 18.538 1.00 14.60 ? 308 LEU A O 1 ATOM 2164 C CB . LEU A 1 282 ? -31.748 5.650 17.853 1.00 15.23 ? 308 LEU A CB 1 ATOM 2165 C CG . LEU A 1 282 ? -33.007 6.075 17.095 1.00 15.64 ? 308 LEU A CG 1 ATOM 2166 C CD1 . LEU A 1 282 ? -33.634 7.316 17.718 1.00 15.84 ? 308 LEU A CD1 1 ATOM 2167 C CD2 . LEU A 1 282 ? -32.661 6.331 15.637 1.00 15.79 ? 308 LEU A CD2 1 ATOM 2168 N N . PRO A 1 283 ? -33.971 3.911 19.948 1.00 14.51 ? 309 PRO A N 1 ATOM 2169 C CA . PRO A 1 283 ? -34.853 2.749 19.939 1.00 14.50 ? 309 PRO A CA 1 ATOM 2170 C C . PRO A 1 283 ? -35.560 2.567 18.602 1.00 14.25 ? 309 PRO A C 1 ATOM 2171 O O . PRO A 1 283 ? -36.118 3.516 18.065 1.00 14.42 ? 309 PRO A O 1 ATOM 2172 C CB . PRO A 1 283 ? -35.853 3.050 21.052 1.00 14.62 ? 309 PRO A CB 1 ATOM 2173 C CG . PRO A 1 283 ? -35.859 4.534 21.173 1.00 14.77 ? 309 PRO A CG 1 ATOM 2174 C CD . PRO A 1 283 ? -34.477 4.990 20.813 1.00 14.59 ? 309 PRO A CD 1 ATOM 2175 N N . GLN A 1 284 ? -35.499 1.350 18.071 1.00 14.00 ? 310 GLN A N 1 ATOM 2176 C CA . GLN A 1 284 ? -36.131 0.997 16.804 1.00 13.88 ? 310 GLN A CA 1 ATOM 2177 C C . GLN A 1 284 ? -36.794 -0.366 16.977 1.00 13.51 ? 310 GLN A C 1 ATOM 2178 O O . GLN A 1 284 ? -36.104 -1.337 17.292 1.00 13.52 ? 310 GLN A O 1 ATOM 2179 C CB . GLN A 1 284 ? -35.081 0.889 15.690 1.00 14.13 ? 310 GLN A CB 1 ATOM 2180 C CG . GLN A 1 284 ? -34.317 2.170 15.365 1.00 14.30 ? 310 GLN A CG 1 ATOM 2181 C CD . GLN A 1 284 ? -35.142 3.155 14.556 1.00 14.45 ? 310 GLN A CD 1 ATOM 2182 O OE1 . GLN A 1 284 ? -35.205 3.068 13.331 1.00 14.61 ? 310 GLN A OE1 1 ATOM 2183 N NE2 . GLN A 1 284 ? -35.775 4.101 15.237 1.00 14.42 ? 310 GLN A NE2 1 ATOM 2184 N N . PRO A 1 285 ? -38.121 -0.456 16.765 1.00 13.08 ? 311 PRO A N 1 ATOM 2185 C CA . PRO A 1 285 ? -38.791 -1.759 16.904 1.00 12.84 ? 311 PRO A CA 1 ATOM 2186 C C . PRO A 1 285 ? -38.114 -2.886 16.109 1.00 12.53 ? 311 PRO A C 1 ATOM 2187 O O . PRO A 1 285 ? -38.010 -4.001 16.599 1.00 12.32 ? 311 PRO A O 1 ATOM 2188 C CB . PRO A 1 285 ? -40.202 -1.495 16.367 1.00 13.02 ? 311 PRO A CB 1 ATOM 2189 C CG . PRO A 1 285 ? -40.412 -0.023 16.525 1.00 13.06 ? 311 PRO A CG 1 ATOM 2190 C CD . PRO A 1 285 ? -39.064 0.623 16.411 1.00 13.03 ? 311 PRO A CD 1 ATOM 2191 N N . TRP A 1 286 ? -37.634 -2.579 14.907 1.00 12.33 ? 312 TRP A N 1 ATOM 2192 C CA . TRP A 1 286 ? -36.999 -3.581 14.048 1.00 12.10 ? 312 TRP A CA 1 ATOM 2193 C C . TRP A 1 286 ? -35.671 -4.123 14.587 1.00 12.08 ? 312 TRP A C 1 ATOM 2194 O O . TRP A 1 286 ? -35.249 -5.206 14.196 1.00 12.13 ? 312 TRP A O 1 ATOM 2195 C CB . TRP A 1 286 ? -36.809 -3.046 12.623 1.00 12.02 ? 312 TRP A CB 1 ATOM 2196 C CG . TRP A 1 286 ? -36.012 -1.783 12.506 1.00 11.93 ? 312 TRP A CG 1 ATOM 2197 C CD1 . TRP A 1 286 ? -36.506 -0.510 12.431 1.00 11.89 ? 312 TRP A CD1 1 ATOM 2198 C CD2 . TRP A 1 286 ? -34.584 -1.665 12.411 1.00 11.89 ? 312 TRP A CD2 1 ATOM 2199 N NE1 . TRP A 1 286 ? -35.478 0.390 12.308 1.00 11.91 ? 312 TRP A NE1 1 ATOM 2200 C CE2 . TRP A 1 286 ? -34.287 -0.289 12.296 1.00 11.91 ? 312 TRP A CE2 1 ATOM 2201 C CE3 . TRP A 1 286 ? -33.530 -2.584 12.421 1.00 11.85 ? 312 TRP A CE3 1 ATOM 2202 C CZ2 . TRP A 1 286 ? -32.977 0.192 12.192 1.00 11.82 ? 312 TRP A CZ2 1 ATOM 2203 C CZ3 . TRP A 1 286 ? -32.227 -2.105 12.316 1.00 11.94 ? 312 TRP A CZ3 1 ATOM 2204 C CH2 . TRP A 1 286 ? -31.965 -0.725 12.207 1.00 11.86 ? 312 TRP A CH2 1 ATOM 2205 N N . ARG A 1 287 ? -35.024 -3.384 15.485 1.00 11.93 ? 313 ARG A N 1 ATOM 2206 C CA . ARG A 1 287 ? -33.800 -3.856 16.133 1.00 11.96 ? 313 ARG A CA 1 ATOM 2207 C C . ARG A 1 287 ? -34.067 -4.931 17.187 1.00 12.02 ? 313 ARG A C 1 ATOM 2208 O O . ARG A 1 287 ? -33.134 -5.626 17.618 1.00 11.99 ? 313 ARG A O 1 ATOM 2209 C CB . ARG A 1 287 ? -33.041 -2.687 16.773 1.00 11.93 ? 313 ARG A CB 1 ATOM 2210 C CG . ARG A 1 287 ? -32.315 -1.803 15.773 1.00 11.96 ? 313 ARG A CG 1 ATOM 2211 C CD . ARG A 1 287 ? -31.664 -0.628 16.475 1.00 12.18 ? 313 ARG A CD 1 ATOM 2212 N NE . ARG A 1 287 ? -30.704 0.080 15.629 1.00 12.26 ? 313 ARG A NE 1 ATOM 2213 C CZ . ARG A 1 287 ? -30.156 1.257 15.930 1.00 12.24 ? 313 ARG A CZ 1 ATOM 2214 N NH1 . ARG A 1 287 ? -30.472 1.888 17.056 1.00 12.08 ? 313 ARG A NH1 1 ATOM 2215 N NH2 . ARG A 1 287 ? -29.279 1.807 15.096 1.00 12.38 ? 313 ARG A NH2 1 ATOM 2216 N N . ALA A 1 288 ? -35.327 -5.056 17.600 1.00 11.86 ? 314 ALA A N 1 ATOM 2217 C CA . ALA A 1 288 ? -35.720 -5.977 18.668 1.00 11.97 ? 314 ALA A CA 1 ATOM 2218 C C . ALA A 1 288 ? -35.744 -7.447 18.280 1.00 11.93 ? 314 ALA A C 1 ATOM 2219 O O . ALA A 1 288 ? -35.690 -8.302 19.168 1.00 12.25 ? 314 ALA A O 1 ATOM 2220 C CB . ALA A 1 288 ? -37.092 -5.586 19.222 1.00 11.91 ? 314 ALA A CB 1 ATOM 2221 N N . ASP A 1 289 ? -35.832 -7.752 16.986 1.00 11.73 ? 315 ASP A N 1 ATOM 2222 C CA . ASP A 1 289 ? -36.253 -9.089 16.562 1.00 11.66 ? 315 ASP A CA 1 ATOM 2223 C C . ASP A 1 289 ? -35.617 -9.586 15.249 1.00 11.36 ? 315 ASP A C 1 ATOM 2224 O O . ASP A 1 289 ? -34.490 -9.220 14.929 1.00 11.22 ? 315 ASP A O 1 ATOM 2225 C CB . ASP A 1 289 ? -37.797 -9.146 16.530 1.00 11.77 ? 315 ASP A CB 1 ATOM 2226 C CG . ASP A 1 289 ? -38.420 -8.205 15.492 1.00 11.88 ? 315 ASP A CG 1 ATOM 2227 O OD1 . ASP A 1 289 ? -37.731 -7.761 14.542 1.00 11.99 ? 315 ASP A OD1 1 ATOM 2228 O OD2 . ASP A 1 289 ? -39.626 -7.921 15.631 1.00 11.90 ? 315 ASP A OD2 1 ATOM 2229 N N . VAL A 1 290 ? -36.336 -10.419 14.497 1.00 11.23 ? 316 VAL A N 1 ATOM 2230 C CA . VAL A 1 290 ? -35.763 -11.095 13.331 1.00 11.19 ? 316 VAL A CA 1 ATOM 2231 C C . VAL A 1 290 ? -35.594 -10.134 12.154 1.00 10.97 ? 316 VAL A C 1 ATOM 2232 O O . VAL A 1 290 ? -34.866 -10.426 11.217 1.00 10.63 ? 316 VAL A O 1 ATOM 2233 C CB . VAL A 1 290 ? -36.595 -12.333 12.926 1.00 11.24 ? 316 VAL A CB 1 ATOM 2234 C CG1 . VAL A 1 290 ? -35.965 -13.065 11.748 1.00 11.27 ? 316 VAL A CG1 1 ATOM 2235 C CG2 . VAL A 1 290 ? -36.732 -13.273 14.114 1.00 11.26 ? 316 VAL A CG2 1 ATOM 2236 N N . THR A 1 291 ? -36.245 -8.977 12.214 1.00 11.16 ? 317 THR A N 1 ATOM 2237 C CA . THR A 1 291 ? -36.057 -7.953 11.192 1.00 11.17 ? 317 THR A CA 1 ATOM 2238 C C . THR A 1 291 ? -34.579 -7.575 11.121 1.00 10.96 ? 317 THR A C 1 ATOM 2239 O O . THR A 1 291 ? -33.957 -7.667 10.062 1.00 10.95 ? 317 THR A O 1 ATOM 2240 C CB . THR A 1 291 ? -36.938 -6.720 11.467 1.00 11.42 ? 317 THR A CB 1 ATOM 2241 O OG1 . THR A 1 291 ? -38.276 -7.147 11.753 1.00 11.47 ? 317 THR A OG1 1 ATOM 2242 C CG2 . THR A 1 291 ? -36.964 -5.788 10.265 1.00 11.51 ? 317 THR A CG2 1 ATOM 2243 N N . TYR A 1 292 ? -34.012 -7.191 12.257 1.00 10.78 ? 318 TYR A N 1 ATOM 2244 C CA . TYR A 1 292 ? -32.590 -6.846 12.333 1.00 10.68 ? 318 TYR A CA 1 ATOM 2245 C C . TYR A 1 292 ? -31.717 -8.052 11.966 1.00 10.67 ? 318 TYR A C 1 ATOM 2246 O O . TYR A 1 292 ? -30.767 -7.919 11.198 1.00 10.54 ? 318 TYR A O 1 ATOM 2247 C CB . TYR A 1 292 ? -32.270 -6.322 13.737 1.00 10.60 ? 318 TYR A CB 1 ATOM 2248 C CG . TYR A 1 292 ? -30.837 -5.893 14.025 1.00 10.51 ? 318 TYR A CG 1 ATOM 2249 C CD1 . TYR A 1 292 ? -30.020 -5.335 13.044 1.00 10.47 ? 318 TYR A CD1 1 ATOM 2250 C CD2 . TYR A 1 292 ? -30.323 -6.000 15.316 1.00 10.52 ? 318 TYR A CD2 1 ATOM 2251 C CE1 . TYR A 1 292 ? -28.723 -4.930 13.341 1.00 10.49 ? 318 TYR A CE1 1 ATOM 2252 C CE2 . TYR A 1 292 ? -29.033 -5.598 15.622 1.00 10.45 ? 318 TYR A CE2 1 ATOM 2253 C CZ . TYR A 1 292 ? -28.236 -5.067 14.637 1.00 10.39 ? 318 TYR A CZ 1 ATOM 2254 O OH . TYR A 1 292 ? -26.961 -4.680 14.960 1.00 10.21 ? 318 TYR A OH 1 ATOM 2255 N N . ALA A 1 293 ? -32.068 -9.222 12.498 1.00 10.76 ? 319 ALA A N 1 ATOM 2256 C CA . ALA A 1 293 ? -31.312 -10.456 12.263 1.00 10.83 ? 319 ALA A CA 1 ATOM 2257 C C . ALA A 1 293 ? -31.241 -10.797 10.781 1.00 10.87 ? 319 ALA A C 1 ATOM 2258 O O . ALA A 1 293 ? -30.159 -11.048 10.247 1.00 10.87 ? 319 ALA A O 1 ATOM 2259 C CB . ALA A 1 293 ? -31.931 -11.615 13.034 1.00 10.85 ? 319 ALA A CB 1 ATOM 2260 N N . ALA A 1 294 ? -32.395 -10.789 10.120 1.00 10.87 ? 320 ALA A N 1 ATOM 2261 C CA . ALA A 1 294 ? -32.473 -11.133 8.703 1.00 10.90 ? 320 ALA A CA 1 ATOM 2262 C C . ALA A 1 294 ? -31.705 -10.127 7.844 1.00 11.05 ? 320 ALA A C 1 ATOM 2263 O O . ALA A 1 294 ? -31.067 -10.506 6.859 1.00 10.86 ? 320 ALA A O 1 ATOM 2264 C CB . ALA A 1 294 ? -33.926 -11.213 8.256 1.00 10.93 ? 320 ALA A CB 1 ATOM 2265 N N . MET A 1 295 ? -31.773 -8.851 8.225 1.00 11.29 ? 321 MET A N 1 ATOM 2266 C CA . MET A 1 295 ? -31.076 -7.792 7.511 1.00 11.66 ? 321 MET A CA 1 ATOM 2267 C C . MET A 1 295 ? -29.560 -7.937 7.637 1.00 11.76 ? 321 MET A C 1 ATOM 2268 O O . MET A 1 295 ? -28.835 -7.710 6.672 1.00 11.87 ? 321 MET A O 1 ATOM 2269 C CB . MET A 1 295 ? -31.510 -6.418 8.017 1.00 11.90 ? 321 MET A CB 1 ATOM 2270 C CG . MET A 1 295 ? -30.864 -5.264 7.261 1.00 12.08 ? 321 MET A CG 1 ATOM 2271 S SD . MET A 1 295 ? -31.544 -3.662 7.721 1.00 12.43 ? 321 MET A SD 1 ATOM 2272 C CE . MET A 1 295 ? -30.594 -2.577 6.652 1.00 12.40 ? 321 MET A CE 1 ATOM 2273 N N . VAL A 1 296 ? -29.087 -8.311 8.823 1.00 11.82 ? 322 VAL A N 1 ATOM 2274 C CA . VAL A 1 296 ? -27.656 -8.562 9.036 1.00 11.88 ? 322 VAL A CA 1 ATOM 2275 C C . VAL A 1 296 ? -27.150 -9.649 8.090 1.00 11.90 ? 322 VAL A C 1 ATOM 2276 O O . VAL A 1 296 ? -26.099 -9.494 7.464 1.00 12.14 ? 322 VAL A O 1 ATOM 2277 C CB . VAL A 1 296 ? -27.369 -8.942 10.505 1.00 11.88 ? 322 VAL A CB 1 ATOM 2278 C CG1 . VAL A 1 296 ? -25.984 -9.554 10.665 1.00 11.92 ? 322 VAL A CG1 1 ATOM 2279 C CG2 . VAL A 1 296 ? -27.517 -7.720 11.393 1.00 11.90 ? 322 VAL A CG2 1 ATOM 2280 N N . VAL A 1 297 ? -27.910 -10.738 7.976 1.00 11.76 ? 323 VAL A N 1 ATOM 2281 C CA . VAL A 1 297 ? -27.584 -11.813 7.038 1.00 11.73 ? 323 VAL A CA 1 ATOM 2282 C C . VAL A 1 297 ? -27.604 -11.303 5.596 1.00 11.76 ? 323 VAL A C 1 ATOM 2283 O O . VAL A 1 297 ? -26.714 -11.613 4.810 1.00 11.75 ? 323 VAL A O 1 ATOM 2284 C CB . VAL A 1 297 ? -28.555 -13.004 7.195 1.00 11.70 ? 323 VAL A CB 1 ATOM 2285 C CG1 . VAL A 1 297 ? -28.358 -14.025 6.085 1.00 11.60 ? 323 VAL A CG1 1 ATOM 2286 C CG2 . VAL A 1 297 ? -28.364 -13.664 8.557 1.00 11.56 ? 323 VAL A CG2 1 ATOM 2287 N N . LYS A 1 298 ? -28.618 -10.513 5.268 1.00 11.94 ? 324 LYS A N 1 ATOM 2288 C CA . LYS A 1 298 ? -28.760 -9.930 3.937 1.00 12.17 ? 324 LYS A CA 1 ATOM 2289 C C . LYS A 1 298 ? -27.552 -9.060 3.564 1.00 12.18 ? 324 LYS A C 1 ATOM 2290 O O . LYS A 1 298 ? -27.023 -9.177 2.458 1.00 11.97 ? 324 LYS A O 1 ATOM 2291 C CB . LYS A 1 298 ? -30.052 -9.113 3.865 1.00 12.26 ? 324 LYS A CB 1 ATOM 2292 C CG . LYS A 1 298 ? -30.254 -8.343 2.574 1.00 12.44 ? 324 LYS A CG 1 ATOM 2293 C CD . LYS A 1 298 ? -31.586 -7.609 2.598 1.00 12.58 ? 324 LYS A CD 1 ATOM 2294 C CE . LYS A 1 298 ? -31.949 -7.063 1.231 1.00 12.58 ? 324 LYS A CE 1 ATOM 2295 N NZ . LYS A 1 298 ? -33.296 -6.442 1.249 1.00 12.75 ? 324 LYS A NZ 1 ATOM 2296 N N . VAL A 1 299 ? -27.123 -8.199 4.486 1.00 12.10 ? 325 VAL A N 1 ATOM 2297 C CA . VAL A 1 299 ? -25.918 -7.379 4.276 1.00 12.17 ? 325 VAL A CA 1 ATOM 2298 C C . VAL A 1 299 ? -24.717 -8.263 3.967 1.00 12.23 ? 325 VAL A C 1 ATOM 2299 O O . VAL A 1 299 ? -23.972 -8.007 3.022 1.00 12.51 ? 325 VAL A O 1 ATOM 2300 C CB . VAL A 1 299 ? -25.603 -6.493 5.504 1.00 12.05 ? 325 VAL A CB 1 ATOM 2301 C CG1 . VAL A 1 299 ? -24.219 -5.866 5.397 1.00 12.10 ? 325 VAL A CG1 1 ATOM 2302 C CG2 . VAL A 1 299 ? -26.652 -5.403 5.656 1.00 12.05 ? 325 VAL A CG2 1 ATOM 2303 N N . ILE A 1 300 ? -24.538 -9.308 4.766 1.00 12.36 ? 326 ILE A N 1 ATOM 2304 C CA . ILE A 1 300 ? -23.417 -10.222 4.590 1.00 12.29 ? 326 ILE A CA 1 ATOM 2305 C C . ILE A 1 300 ? -23.517 -10.939 3.239 1.00 12.49 ? 326 ILE A C 1 ATOM 2306 O O . ILE A 1 300 ? -22.535 -11.009 2.496 1.00 12.50 ? 326 ILE A O 1 ATOM 2307 C CB . ILE A 1 300 ? -23.319 -11.209 5.779 1.00 12.19 ? 326 ILE A CB 1 ATOM 2308 C CG1 . ILE A 1 300 ? -22.762 -10.469 7.003 1.00 12.09 ? 326 ILE A CG1 1 ATOM 2309 C CG2 . ILE A 1 300 ? -22.428 -12.399 5.446 1.00 12.17 ? 326 ILE A CG2 1 ATOM 2310 C CD1 . ILE A 1 300 ? -23.080 -11.115 8.332 1.00 12.05 ? 326 ILE A CD1 1 ATOM 2311 N N . ALA A 1 301 ? -24.709 -11.434 2.911 1.00 12.66 ? 327 ALA A N 1 ATOM 2312 C CA . ALA A 1 301 ? -24.941 -12.098 1.628 1.00 12.76 ? 327 ALA A CA 1 ATOM 2313 C C . ALA A 1 301 ? -24.611 -11.180 0.450 1.00 12.80 ? 327 ALA A C 1 ATOM 2314 O O . ALA A 1 301 ? -24.010 -11.620 -0.523 1.00 12.70 ? 327 ALA A O 1 ATOM 2315 C CB . ALA A 1 301 ? -26.376 -12.593 1.529 1.00 12.82 ? 327 ALA A CB 1 ATOM 2316 N N . GLN A 1 302 ? -24.997 -9.909 0.546 1.00 12.93 ? 328 GLN A N 1 ATOM 2317 C CA . GLN A 1 302 ? -24.680 -8.936 -0.502 1.00 13.21 ? 328 GLN A CA 1 ATOM 2318 C C . GLN A 1 302 ? -23.166 -8.778 -0.676 1.00 13.32 ? 328 GLN A C 1 ATOM 2319 O O . GLN A 1 302 ? -22.669 -8.697 -1.797 1.00 13.58 ? 328 GLN A O 1 ATOM 2320 C CB . GLN A 1 302 ? -25.329 -7.581 -0.203 1.00 13.22 ? 328 GLN A CB 1 ATOM 2321 C CG . GLN A 1 302 ? -26.848 -7.585 -0.343 1.00 13.19 ? 328 GLN A CG 1 ATOM 2322 C CD . GLN A 1 302 ? -27.522 -6.367 0.268 1.00 13.10 ? 328 GLN A CD 1 ATOM 2323 O OE1 . GLN A 1 302 ? -26.912 -5.615 1.026 1.00 13.12 ? 328 GLN A OE1 1 ATOM 2324 N NE2 . GLN A 1 302 ? -28.793 -6.168 -0.065 1.00 13.13 ? 328 GLN A NE2 1 ATOM 2325 N N . HIS A 1 303 ? -22.433 -8.747 0.431 1.00 13.49 ? 329 HIS A N 1 ATOM 2326 C CA . HIS A 1 303 ? -20.983 -8.607 0.362 1.00 13.55 ? 329 HIS A CA 1 ATOM 2327 C C . HIS A 1 303 ? -20.321 -9.852 -0.206 1.00 13.79 ? 329 HIS A C 1 ATOM 2328 O O . HIS A 1 303 ? -19.425 -9.748 -1.035 1.00 13.71 ? 329 HIS A O 1 ATOM 2329 C CB . HIS A 1 303 ? -20.401 -8.253 1.727 1.00 13.49 ? 329 HIS A CB 1 ATOM 2330 C CG . HIS A 1 303 ? -20.599 -6.820 2.095 1.00 13.56 ? 329 HIS A CG 1 ATOM 2331 N ND1 . HIS A 1 303 ? -21.810 -6.322 2.528 1.00 13.49 ? 329 HIS A ND1 1 ATOM 2332 C CD2 . HIS A 1 303 ? -19.746 -5.769 2.069 1.00 13.55 ? 329 HIS A CD2 1 ATOM 2333 C CE1 . HIS A 1 303 ? -21.688 -5.028 2.764 1.00 13.64 ? 329 HIS A CE1 1 ATOM 2334 N NE2 . HIS A 1 303 ? -20.449 -4.669 2.489 1.00 13.53 ? 329 HIS A NE2 1 ATOM 2335 N N . GLN A 1 304 ? -20.759 -11.031 0.218 1.00 14.30 ? 330 GLN A N 1 ATOM 2336 C CA . GLN A 1 304 ? -20.200 -12.255 -0.349 1.00 14.69 ? 330 GLN A CA 1 ATOM 2337 C C . GLN A 1 304 ? -20.503 -12.344 -1.841 1.00 15.11 ? 330 GLN A C 1 ATOM 2338 O O . GLN A 1 304 ? -19.602 -12.570 -2.644 1.00 15.28 ? 330 GLN A O 1 ATOM 2339 C CB . GLN A 1 304 ? -20.730 -13.504 0.361 1.00 14.66 ? 330 GLN A CB 1 ATOM 2340 C CG . GLN A 1 304 ? -20.160 -14.817 -0.178 1.00 14.61 ? 330 GLN A CG 1 ATOM 2341 C CD . GLN A 1 304 ? -18.636 -14.884 -0.111 1.00 14.51 ? 330 GLN A CD 1 ATOM 2342 O OE1 . GLN A 1 304 ? -18.018 -14.278 0.759 1.00 14.45 ? 330 GLN A OE1 1 ATOM 2343 N NE2 . GLN A 1 304 ? -18.031 -15.645 -1.016 1.00 14.15 ? 330 GLN A NE2 1 ATOM 2344 N N . ASN A 1 305 ? -21.769 -12.149 -2.202 1.00 15.51 ? 331 ASN A N 1 ATOM 2345 C CA . ASN A 1 305 ? -22.237 -12.434 -3.556 1.00 15.95 ? 331 ASN A CA 1 ATOM 2346 C C . ASN A 1 305 ? -21.975 -11.332 -4.577 1.00 16.52 ? 331 ASN A C 1 ATOM 2347 O O . ASN A 1 305 ? -21.729 -11.630 -5.740 1.00 16.29 ? 331 ASN A O 1 ATOM 2348 C CB . ASN A 1 305 ? -23.731 -12.776 -3.545 1.00 15.98 ? 331 ASN A CB 1 ATOM 2349 C CG . ASN A 1 305 ? -24.025 -14.098 -2.853 1.00 16.18 ? 331 ASN A CG 1 ATOM 2350 O OD1 . ASN A 1 305 ? -23.170 -14.980 -2.775 1.00 16.40 ? 331 ASN A OD1 1 ATOM 2351 N ND2 . ASN A 1 305 ? -25.249 -14.246 -2.359 1.00 16.23 ? 331 ASN A ND2 1 ATOM 2352 N N . LEU A 1 306 ? -22.038 -10.071 -4.156 1.00 17.32 ? 332 LEU A N 1 ATOM 2353 C CA . LEU A 1 306 ? -21.870 -8.945 -5.084 1.00 18.18 ? 332 LEU A CA 1 ATOM 2354 C C . LEU A 1 306 ? -20.486 -8.305 -5.032 1.00 19.15 ? 332 LEU A C 1 ATOM 2355 O O . LEU A 1 306 ? -20.239 -7.337 -5.744 1.00 19.28 ? 332 LEU A O 1 ATOM 2356 C CB . LEU A 1 306 ? -22.923 -7.873 -4.809 1.00 18.08 ? 332 LEU A CB 1 ATOM 2357 C CG . LEU A 1 306 ? -24.361 -8.380 -4.702 1.00 17.97 ? 332 LEU A CG 1 ATOM 2358 C CD1 . LEU A 1 306 ? -25.290 -7.234 -4.340 1.00 18.02 ? 332 LEU A CD1 1 ATOM 2359 C CD2 . LEU A 1 306 ? -24.796 -9.034 -6.006 1.00 18.08 ? 332 LEU A CD2 1 ATOM 2360 N N . LEU A 1 307 ? -19.594 -8.833 -4.195 1.00 20.44 ? 333 LEU A N 1 ATOM 2361 C CA . LEU A 1 307 ? -18.241 -8.284 -4.056 1.00 21.28 ? 333 LEU A CA 1 ATOM 2362 C C . LEU A 1 307 ? -17.162 -9.363 -4.001 1.00 22.22 ? 333 LEU A C 1 ATOM 2363 O O . LEU A 1 307 ? -16.229 -9.342 -4.798 1.00 22.15 ? 333 LEU A O 1 ATOM 2364 C CB . LEU A 1 307 ? -18.144 -7.409 -2.808 1.00 21.65 ? 333 LEU A CB 1 ATOM 2365 C CG . LEU A 1 307 ? -16.820 -6.660 -2.614 1.00 21.86 ? 333 LEU A CG 1 ATOM 2366 C CD1 . LEU A 1 307 ? -16.657 -5.568 -3.659 1.00 22.28 ? 333 LEU A CD1 1 ATOM 2367 C CD2 . LEU A 1 307 ? -16.742 -6.077 -1.217 1.00 21.93 ? 333 LEU A CD2 1 ATOM 2368 N N . LEU A 1 308 ? -17.294 -10.304 -3.068 1.00 23.18 ? 334 LEU A N 1 ATOM 2369 C CA . LEU A 1 308 ? -16.257 -11.320 -2.842 1.00 24.04 ? 334 LEU A CA 1 ATOM 2370 C C . LEU A 1 308 ? -16.340 -12.558 -3.744 1.00 24.95 ? 334 LEU A C 1 ATOM 2371 O O . LEU A 1 308 ? -15.343 -13.254 -3.918 1.00 25.62 ? 334 LEU A O 1 ATOM 2372 C CB . LEU A 1 308 ? -16.263 -11.767 -1.374 1.00 23.89 ? 334 LEU A CB 1 ATOM 2373 C CG . LEU A 1 308 ? -15.914 -10.683 -0.352 1.00 23.66 ? 334 LEU A CG 1 ATOM 2374 C CD1 . LEU A 1 308 ? -16.179 -11.179 1.058 1.00 23.34 ? 334 LEU A CD1 1 ATOM 2375 C CD2 . LEU A 1 308 ? -14.465 -10.239 -0.503 1.00 23.71 ? 334 LEU A CD2 1 ATOM 2376 N N . ALA A 1 309 ? -17.511 -12.839 -4.310 1.00 25.62 ? 335 ALA A N 1 ATOM 2377 C CA . ALA A 1 309 ? -17.718 -14.082 -5.058 1.00 26.01 ? 335 ALA A CA 1 ATOM 2378 C C . ALA A 1 309 ? -16.879 -14.135 -6.331 1.00 26.11 ? 335 ALA A C 1 ATOM 2379 O O . ALA A 1 309 ? -17.265 -13.579 -7.355 1.00 27.19 ? 335 ALA A O 1 ATOM 2380 C CB . ALA A 1 309 ? -19.192 -14.262 -5.385 1.00 26.23 ? 335 ALA A CB 1 ATOM 2381 N N . ALA A 1 314 ? -13.822 -6.848 -7.237 1.00 31.87 ? 340 ALA A N 1 ATOM 2382 C CA . ALA A 1 314 ? -12.779 -7.234 -6.295 1.00 31.56 ? 340 ALA A CA 1 ATOM 2383 C C . ALA A 1 314 ? -11.938 -6.052 -5.816 1.00 31.14 ? 340 ALA A C 1 ATOM 2384 O O . ALA A 1 314 ? -11.103 -5.534 -6.560 1.00 33.30 ? 340 ALA A O 1 ATOM 2385 C CB . ALA A 1 314 ? -11.871 -8.288 -6.918 1.00 31.96 ? 340 ALA A CB 1 ATOM 2386 N N . PHE A 1 315 ? -12.191 -5.611 -4.587 1.00 28.58 ? 341 PHE A N 1 ATOM 2387 C CA . PHE A 1 315 ? -11.170 -4.938 -3.782 1.00 26.62 ? 341 PHE A CA 1 ATOM 2388 C C . PHE A 1 315 ? -11.025 -5.772 -2.510 1.00 23.64 ? 341 PHE A C 1 ATOM 2389 O O . PHE A 1 315 ? -11.898 -6.585 -2.213 1.00 22.62 ? 341 PHE A O 1 ATOM 2390 C CB . PHE A 1 315 ? -11.501 -3.460 -3.517 1.00 27.14 ? 341 PHE A CB 1 ATOM 2391 C CG . PHE A 1 315 ? -12.864 -3.222 -2.946 1.00 27.51 ? 341 PHE A CG 1 ATOM 2392 C CD1 . PHE A 1 315 ? -13.924 -2.901 -3.778 1.00 27.68 ? 341 PHE A CD1 1 ATOM 2393 C CD2 . PHE A 1 315 ? -13.082 -3.287 -1.572 1.00 28.02 ? 341 PHE A CD2 1 ATOM 2394 C CE1 . PHE A 1 315 ? -15.183 -2.665 -3.256 1.00 28.01 ? 341 PHE A CE1 1 ATOM 2395 C CE2 . PHE A 1 315 ? -14.344 -3.059 -1.041 1.00 28.12 ? 341 PHE A CE2 1 ATOM 2396 C CZ . PHE A 1 315 ? -15.398 -2.747 -1.885 1.00 28.07 ? 341 PHE A CZ 1 ATOM 2397 N N . PRO A 1 316 ? -9.909 -5.612 -1.778 1.00 21.17 ? 342 PRO A N 1 ATOM 2398 C CA . PRO A 1 316 ? -9.595 -6.555 -0.701 1.00 19.82 ? 342 PRO A CA 1 ATOM 2399 C C . PRO A 1 316 ? -10.396 -6.309 0.583 1.00 18.63 ? 342 PRO A C 1 ATOM 2400 O O . PRO A 1 316 ? -9.836 -5.980 1.623 1.00 17.90 ? 342 PRO A O 1 ATOM 2401 C CB . PRO A 1 316 ? -8.101 -6.320 -0.478 1.00 20.04 ? 342 PRO A CB 1 ATOM 2402 C CG . PRO A 1 316 ? -7.919 -4.880 -0.788 1.00 20.20 ? 342 PRO A CG 1 ATOM 2403 C CD . PRO A 1 316 ? -8.889 -4.553 -1.887 1.00 20.75 ? 342 PRO A CD 1 ATOM 2404 N N . TYR A 1 317 ? -11.708 -6.485 0.494 1.00 17.74 ? 343 TYR A N 1 ATOM 2405 C CA . TYR A 1 317 ? -12.601 -6.349 1.634 1.00 16.64 ? 343 TYR A CA 1 ATOM 2406 C C . TYR A 1 317 ? -12.412 -7.578 2.510 1.00 15.97 ? 343 TYR A C 1 ATOM 2407 O O . TYR A 1 317 ? -12.591 -8.698 2.035 1.00 16.14 ? 343 TYR A O 1 ATOM 2408 C CB . TYR A 1 317 ? -14.038 -6.268 1.129 1.00 16.42 ? 343 TYR A CB 1 ATOM 2409 C CG . TYR A 1 317 ? -15.053 -5.854 2.155 1.00 16.21 ? 343 TYR A CG 1 ATOM 2410 C CD1 . TYR A 1 317 ? -15.285 -4.512 2.418 1.00 16.25 ? 343 TYR A CD1 1 ATOM 2411 C CD2 . TYR A 1 317 ? -15.799 -6.801 2.849 1.00 16.05 ? 343 TYR A CD2 1 ATOM 2412 C CE1 . TYR A 1 317 ? -16.233 -4.116 3.344 1.00 16.18 ? 343 TYR A CE1 1 ATOM 2413 C CE2 . TYR A 1 317 ? -16.750 -6.416 3.778 1.00 16.07 ? 343 TYR A CE2 1 ATOM 2414 C CZ . TYR A 1 317 ? -16.960 -5.069 4.023 1.00 15.99 ? 343 TYR A CZ 1 ATOM 2415 O OH . TYR A 1 317 ? -17.896 -4.671 4.942 1.00 15.71 ? 343 TYR A OH 1 ATOM 2416 N N . ALA A 1 318 ? -12.042 -7.368 3.774 1.00 15.15 ? 344 ALA A N 1 ATOM 2417 C CA . ALA A 1 318 ? -11.583 -8.466 4.638 1.00 14.60 ? 344 ALA A CA 1 ATOM 2418 C C . ALA A 1 318 ? -12.344 -8.646 5.952 1.00 14.17 ? 344 ALA A C 1 ATOM 2419 O O . ALA A 1 318 ? -12.242 -9.704 6.572 1.00 13.87 ? 344 ALA A O 1 ATOM 2420 C CB . ALA A 1 318 ? -10.094 -8.306 4.934 1.00 14.54 ? 344 ALA A CB 1 ATOM 2421 N N . LEU A 1 319 ? -13.086 -7.629 6.385 1.00 13.83 ? 345 LEU A N 1 ATOM 2422 C CA . LEU A 1 319 ? -13.794 -7.700 7.659 1.00 13.43 ? 345 LEU A CA 1 ATOM 2423 C C . LEU A 1 319 ? -15.021 -6.790 7.681 1.00 13.26 ? 345 LEU A C 1 ATOM 2424 O O . LEU A 1 319 ? -14.965 -5.654 7.200 1.00 13.13 ? 345 LEU A O 1 ATOM 2425 C CB . LEU A 1 319 ? -12.845 -7.327 8.794 1.00 13.44 ? 345 LEU A CB 1 ATOM 2426 C CG . LEU A 1 319 ? -13.368 -7.465 10.226 1.00 13.62 ? 345 LEU A CG 1 ATOM 2427 C CD1 . LEU A 1 319 ? -12.259 -7.957 11.154 1.00 13.65 ? 345 LEU A CD1 1 ATOM 2428 C CD2 . LEU A 1 319 ? -13.971 -6.161 10.741 1.00 13.48 ? 345 LEU A CD2 1 ATOM 2429 N N . LEU A 1 320 ? -16.116 -7.313 8.241 1.00 13.04 ? 346 LEU A N 1 ATOM 2430 C CA . LEU A 1 320 ? -17.357 -6.572 8.452 1.00 13.00 ? 346 LEU A CA 1 ATOM 2431 C C . LEU A 1 320 ? -17.777 -6.773 9.901 1.00 12.96 ? 346 LEU A C 1 ATOM 2432 O O . LEU A 1 320 ? -17.913 -7.911 10.361 1.00 13.42 ? 346 LEU A O 1 ATOM 2433 C CB . LEU A 1 320 ? -18.451 -7.074 7.506 1.00 13.07 ? 346 LEU A CB 1 ATOM 2434 C CG . LEU A 1 320 ? -19.784 -6.311 7.462 1.00 13.10 ? 346 LEU A CG 1 ATOM 2435 C CD1 . LEU A 1 320 ? -20.471 -6.536 6.123 1.00 13.12 ? 346 LEU A CD1 1 ATOM 2436 C CD2 . LEU A 1 320 ? -20.726 -6.682 8.599 1.00 13.12 ? 346 LEU A CD2 1 ATOM 2437 N N . SER A 1 321 ? -17.963 -5.676 10.627 1.00 12.66 ? 347 SER A N 1 ATOM 2438 C CA . SER A 1 321 ? -18.347 -5.749 12.029 1.00 12.49 ? 347 SER A CA 1 ATOM 2439 C C . SER A 1 321 ? -19.626 -4.970 12.296 1.00 12.45 ? 347 SER A C 1 ATOM 2440 O O . SER A 1 321 ? -19.727 -3.781 11.972 1.00 12.05 ? 347 SER A O 1 ATOM 2441 C CB . SER A 1 321 ? -17.234 -5.216 12.928 1.00 12.40 ? 347 SER A CB 1 ATOM 2442 O OG . SER A 1 321 ? -17.514 -5.507 14.280 1.00 12.08 ? 347 SER A OG 1 ATOM 2443 N N . ASN A 1 322 ? -20.599 -5.667 12.876 1.00 12.61 ? 348 ASN A N 1 ATOM 2444 C CA . ASN A 1 322 ? -21.801 -5.045 13.402 1.00 12.70 ? 348 ASN A CA 1 ATOM 2445 C C . ASN A 1 322 ? -21.498 -4.601 14.825 1.00 12.88 ? 348 ASN A C 1 ATOM 2446 O O . ASN A 1 322 ? -21.165 -5.419 15.682 1.00 12.72 ? 348 ASN A O 1 ATOM 2447 C CB . ASN A 1 322 ? -22.967 -6.028 13.371 1.00 12.73 ? 348 ASN A CB 1 ATOM 2448 C CG . ASN A 1 322 ? -23.433 -6.331 11.961 1.00 12.73 ? 348 ASN A CG 1 ATOM 2449 O OD1 . ASN A 1 322 ? -22.971 -7.286 11.333 1.00 13.30 ? 348 ASN A OD1 1 ATOM 2450 N ND2 . ASN A 1 322 ? -24.342 -5.517 11.451 1.00 12.44 ? 348 ASN A ND2 1 ATOM 2451 N N . ASP A 1 323 ? -21.606 -3.299 15.065 1.00 13.05 ? 349 ASP A N 1 ATOM 2452 C CA . ASP A 1 323 ? -21.190 -2.698 16.325 1.00 13.13 ? 349 ASP A CA 1 ATOM 2453 C C . ASP A 1 323 ? -22.343 -2.784 17.330 1.00 13.22 ? 349 ASP A C 1 ATOM 2454 O O . ASP A 1 323 ? -22.970 -1.774 17.664 1.00 13.12 ? 349 ASP A O 1 ATOM 2455 C CB . ASP A 1 323 ? -20.777 -1.246 16.064 1.00 13.30 ? 349 ASP A CB 1 ATOM 2456 C CG . ASP A 1 323 ? -19.828 -0.710 17.100 1.00 13.35 ? 349 ASP A CG 1 ATOM 2457 O OD1 . ASP A 1 323 ? -18.813 -1.379 17.396 1.00 13.57 ? 349 ASP A OD1 1 ATOM 2458 O OD2 . ASP A 1 323 ? -20.091 0.395 17.609 1.00 13.60 ? 349 ASP A OD2 1 ATOM 2459 N N . ASN A 1 324 ? -22.610 -3.998 17.818 1.00 13.12 ? 350 ASN A N 1 ATOM 2460 C CA . ASN A 1 324 ? -23.837 -4.268 18.572 1.00 13.11 ? 350 ASN A CA 1 ATOM 2461 C C . ASN A 1 324 ? -23.652 -5.064 19.870 1.00 13.16 ? 350 ASN A C 1 ATOM 2462 O O . ASN A 1 324 ? -24.564 -5.764 20.310 1.00 13.08 ? 350 ASN A O 1 ATOM 2463 C CB . ASN A 1 324 ? -24.867 -4.959 17.659 1.00 12.90 ? 350 ASN A CB 1 ATOM 2464 C CG . ASN A 1 324 ? -24.342 -6.240 17.039 1.00 12.93 ? 350 ASN A CG 1 ATOM 2465 O OD1 . ASN A 1 324 ? -23.257 -6.711 17.380 1.00 12.82 ? 350 ASN A OD1 1 ATOM 2466 N ND2 . ASN A 1 324 ? -25.116 -6.815 16.119 1.00 12.88 ? 350 ASN A ND2 1 ATOM 2467 N N . ALA A 1 325 ? -22.485 -4.938 20.493 1.00 13.30 ? 351 ALA A N 1 ATOM 2468 C CA . ALA A 1 325 ? -22.229 -5.592 21.778 1.00 13.48 ? 351 ALA A CA 1 ATOM 2469 C C . ALA A 1 325 ? -22.564 -4.674 22.961 1.00 13.64 ? 351 ALA A C 1 ATOM 2470 O O . ALA A 1 325 ? -22.224 -4.984 24.097 1.00 13.92 ? 351 ALA A O 1 ATOM 2471 C CB . ALA A 1 325 ? -20.781 -6.057 21.859 1.00 13.47 ? 351 ALA A CB 1 ATOM 2472 N N . PHE A 1 326 ? -23.232 -3.556 22.691 1.00 13.81 ? 352 PHE A N 1 ATOM 2473 C CA . PHE A 1 326 ? -23.687 -2.640 23.739 1.00 14.08 ? 352 PHE A CA 1 ATOM 2474 C C . PHE A 1 326 ? -24.718 -3.330 24.634 1.00 13.95 ? 352 PHE A C 1 ATOM 2475 O O . PHE A 1 326 ? -25.418 -4.247 24.202 1.00 13.91 ? 352 PHE A O 1 ATOM 2476 C CB . PHE A 1 326 ? -24.344 -1.385 23.141 1.00 14.18 ? 352 PHE A CB 1 ATOM 2477 C CG . PHE A 1 326 ? -23.413 -0.510 22.344 1.00 14.37 ? 352 PHE A CG 1 ATOM 2478 C CD1 . PHE A 1 326 ? -23.165 -0.768 20.998 1.00 14.41 ? 352 PHE A CD1 1 ATOM 2479 C CD2 . PHE A 1 326 ? -22.817 0.599 22.931 1.00 14.57 ? 352 PHE A CD2 1 ATOM 2480 C CE1 . PHE A 1 326 ? -22.310 0.047 20.268 1.00 14.75 ? 352 PHE A CE1 1 ATOM 2481 C CE2 . PHE A 1 326 ? -21.972 1.420 22.206 1.00 14.75 ? 352 PHE A CE2 1 ATOM 2482 C CZ . PHE A 1 326 ? -21.713 1.143 20.870 1.00 14.67 ? 352 PHE A CZ 1 ATOM 2483 N N . LEU A 1 327 ? -24.799 -2.875 25.880 1.00 14.01 ? 353 LEU A N 1 ATOM 2484 C CA . LEU A 1 327 ? -25.866 -3.268 26.791 1.00 14.22 ? 353 LEU A CA 1 ATOM 2485 C C . LEU A 1 327 ? -27.012 -2.274 26.673 1.00 14.26 ? 353 LEU A C 1 ATOM 2486 O O . LEU A 1 327 ? -26.787 -1.066 26.611 1.00 13.86 ? 353 LEU A O 1 ATOM 2487 C CB . LEU A 1 327 ? -25.365 -3.289 28.233 1.00 14.44 ? 353 LEU A CB 1 ATOM 2488 C CG . LEU A 1 327 ? -24.514 -4.486 28.653 1.00 14.56 ? 353 LEU A CG 1 ATOM 2489 C CD1 . LEU A 1 327 ? -23.845 -4.196 29.985 1.00 14.75 ? 353 LEU A CD1 1 ATOM 2490 C CD2 . LEU A 1 327 ? -25.362 -5.743 28.734 1.00 14.69 ? 353 LEU A CD2 1 ATOM 2491 N N . SER A 1 328 ? -28.238 -2.784 26.652 1.00 14.53 ? 354 SER A N 1 ATOM 2492 C CA . SER A 1 328 ? -29.412 -1.926 26.516 1.00 14.99 ? 354 SER A CA 1 ATOM 2493 C C . SER A 1 328 ? -29.819 -1.271 27.839 1.00 15.40 ? 354 SER A C 1 ATOM 2494 O O . SER A 1 328 ? -29.471 -1.749 28.923 1.00 14.92 ? 354 SER A O 1 ATOM 2495 C CB . SER A 1 328 ? -30.589 -2.707 25.931 1.00 14.81 ? 354 SER A CB 1 ATOM 2496 O OG . SER A 1 328 ? -30.953 -3.779 26.774 1.00 14.60 ? 354 SER A OG 1 ATOM 2497 N N . TYR A 1 329 ? -30.554 -0.168 27.719 1.00 16.21 ? 355 TYR A N 1 ATOM 2498 C CA . TYR A 1 329 ? -31.037 0.607 28.856 1.00 17.05 ? 355 TYR A CA 1 ATOM 2499 C C . TYR A 1 329 ? -32.553 0.617 28.893 1.00 16.62 ? 355 TYR A C 1 ATOM 2500 O O . TYR A 1 329 ? -33.202 0.565 27.848 1.00 16.45 ? 355 TYR A O 1 ATOM 2501 C CB . TYR A 1 329 ? -30.555 2.051 28.750 1.00 18.09 ? 355 TYR A CB 1 ATOM 2502 C CG . TYR A 1 329 ? -29.080 2.227 28.989 1.00 19.33 ? 355 TYR A CG 1 ATOM 2503 C CD1 . TYR A 1 329 ? -28.573 2.286 30.284 1.00 20.11 ? 355 TYR A CD1 1 ATOM 2504 C CD2 . TYR A 1 329 ? -28.190 2.342 27.927 1.00 20.18 ? 355 TYR A CD2 1 ATOM 2505 C CE1 . TYR A 1 329 ? -27.222 2.452 30.516 1.00 20.60 ? 355 TYR A CE1 1 ATOM 2506 C CE2 . TYR A 1 329 ? -26.834 2.506 28.152 1.00 20.94 ? 355 TYR A CE2 1 ATOM 2507 C CZ . TYR A 1 329 ? -26.361 2.559 29.450 1.00 21.12 ? 355 TYR A CZ 1 ATOM 2508 O OH . TYR A 1 329 ? -25.022 2.730 29.680 1.00 22.35 ? 355 TYR A OH 1 ATOM 2509 N N . HIS A 1 330 ? -33.107 0.685 30.103 1.00 16.57 ? 356 HIS A N 1 ATOM 2510 C CA . HIS A 1 330 ? -34.532 0.949 30.306 1.00 16.61 ? 356 HIS A CA 1 ATOM 2511 C C . HIS A 1 330 ? -34.839 2.328 29.727 1.00 16.37 ? 356 HIS A C 1 ATOM 2512 O O . HIS A 1 330 ? -34.046 3.257 29.913 1.00 15.88 ? 356 HIS A O 1 ATOM 2513 C CB . HIS A 1 330 ? -34.867 0.911 31.807 1.00 16.93 ? 356 HIS A CB 1 ATOM 2514 C CG . HIS A 1 330 ? -36.275 1.310 32.137 1.00 17.46 ? 356 HIS A CG 1 ATOM 2515 N ND1 . HIS A 1 330 ? -36.633 2.610 32.427 1.00 17.91 ? 356 HIS A ND1 1 ATOM 2516 C CD2 . HIS A 1 330 ? -37.410 0.577 32.245 1.00 17.80 ? 356 HIS A CD2 1 ATOM 2517 C CE1 . HIS A 1 330 ? -37.929 2.664 32.683 1.00 18.00 ? 356 HIS A CE1 1 ATOM 2518 N NE2 . HIS A 1 330 ? -38.424 1.443 32.583 1.00 17.92 ? 356 HIS A NE2 1 ATOM 2519 N N . PRO A 1 331 ? -35.987 2.479 29.037 1.00 16.03 ? 357 PRO A N 1 ATOM 2520 C CA . PRO A 1 331 ? -37.091 1.544 28.817 1.00 16.08 ? 357 PRO A CA 1 ATOM 2521 C C . PRO A 1 331 ? -37.017 0.756 27.505 1.00 15.79 ? 357 PRO A C 1 ATOM 2522 O O . PRO A 1 331 ? -38.064 0.385 26.966 1.00 16.08 ? 357 PRO A O 1 ATOM 2523 C CB . PRO A 1 331 ? -38.293 2.487 28.769 1.00 16.08 ? 357 PRO A CB 1 ATOM 2524 C CG . PRO A 1 331 ? -37.752 3.670 28.036 1.00 16.10 ? 357 PRO A CG 1 ATOM 2525 C CD . PRO A 1 331 ? -36.299 3.791 28.443 1.00 16.12 ? 357 PRO A CD 1 ATOM 2526 N N . HIS A 1 332 ? -35.806 0.495 27.007 1.00 15.26 ? 358 HIS A N 1 ATOM 2527 C CA . HIS A 1 332 ? -35.617 -0.127 25.693 1.00 14.84 ? 358 HIS A CA 1 ATOM 2528 C C . HIS A 1 332 ? -34.793 -1.414 25.766 1.00 14.05 ? 358 HIS A C 1 ATOM 2529 O O . HIS A 1 332 ? -33.745 -1.514 25.137 1.00 13.94 ? 358 HIS A O 1 ATOM 2530 C CB . HIS A 1 332 ? -34.933 0.864 24.747 1.00 15.04 ? 358 HIS A CB 1 ATOM 2531 C CG . HIS A 1 332 ? -35.623 2.186 24.667 1.00 15.34 ? 358 HIS A CG 1 ATOM 2532 N ND1 . HIS A 1 332 ? -36.912 2.320 24.200 1.00 15.46 ? 358 HIS A ND1 1 ATOM 2533 C CD2 . HIS A 1 332 ? -35.209 3.431 25.000 1.00 15.49 ? 358 HIS A CD2 1 ATOM 2534 C CE1 . HIS A 1 332 ? -37.262 3.591 24.248 1.00 15.66 ? 358 HIS A CE1 1 ATOM 2535 N NE2 . HIS A 1 332 ? -36.248 4.287 24.733 1.00 15.69 ? 358 HIS A NE2 1 ATOM 2536 N N . PRO A 1 333 ? -35.271 -2.413 26.519 1.00 13.51 ? 359 PRO A N 1 ATOM 2537 C CA . PRO A 1 333 ? -34.484 -3.651 26.621 1.00 13.27 ? 359 PRO A CA 1 ATOM 2538 C C . PRO A 1 333 ? -34.183 -4.311 25.269 1.00 12.67 ? 359 PRO A C 1 ATOM 2539 O O . PRO A 1 333 ? -33.073 -4.776 25.060 1.00 12.54 ? 359 PRO A O 1 ATOM 2540 C CB . PRO A 1 333 ? -35.349 -4.572 27.495 1.00 13.26 ? 359 PRO A CB 1 ATOM 2541 C CG . PRO A 1 333 ? -36.661 -3.898 27.653 1.00 13.40 ? 359 PRO A CG 1 ATOM 2542 C CD . PRO A 1 333 ? -36.476 -2.443 27.359 1.00 13.47 ? 359 PRO A CD 1 ATOM 2543 N N . PHE A 1 334 ? -35.157 -4.317 24.365 1.00 12.29 ? 360 PHE A N 1 ATOM 2544 C CA . PHE A 1 334 ? -35.029 -5.009 23.078 1.00 12.16 ? 360 PHE A CA 1 ATOM 2545 C C . PHE A 1 334 ? -34.714 -4.105 21.883 1.00 12.13 ? 360 PHE A C 1 ATOM 2546 O O . PHE A 1 334 ? -34.089 -4.558 20.937 1.00 12.33 ? 360 PHE A O 1 ATOM 2547 C CB . PHE A 1 334 ? -36.313 -5.790 22.774 1.00 11.90 ? 360 PHE A CB 1 ATOM 2548 C CG . PHE A 1 334 ? -36.513 -6.993 23.646 1.00 11.69 ? 360 PHE A CG 1 ATOM 2549 C CD1 . PHE A 1 334 ? -35.835 -8.176 23.385 1.00 11.60 ? 360 PHE A CD1 1 ATOM 2550 C CD2 . PHE A 1 334 ? -37.389 -6.954 24.720 1.00 11.67 ? 360 PHE A CD2 1 ATOM 2551 C CE1 . PHE A 1 334 ? -36.019 -9.292 24.185 1.00 11.45 ? 360 PHE A CE1 1 ATOM 2552 C CE2 . PHE A 1 334 ? -37.577 -8.071 25.521 1.00 11.51 ? 360 PHE A CE2 1 ATOM 2553 C CZ . PHE A 1 334 ? -36.893 -9.238 25.252 1.00 11.32 ? 360 PHE A CZ 1 ATOM 2554 N N . ALA A 1 335 ? -35.124 -2.840 21.929 1.00 12.05 ? 361 ALA A N 1 ATOM 2555 C CA . ALA A 1 335 ? -35.159 -1.990 20.727 1.00 12.05 ? 361 ALA A CA 1 ATOM 2556 C C . ALA A 1 335 ? -33.863 -1.262 20.375 1.00 12.09 ? 361 ALA A C 1 ATOM 2557 O O . ALA A 1 335 ? -33.831 -0.514 19.395 1.00 12.29 ? 361 ALA A O 1 ATOM 2558 C CB . ALA A 1 335 ? -36.295 -0.982 20.836 1.00 11.91 ? 361 ALA A CB 1 ATOM 2559 N N . GLN A 1 336 ? -32.800 -1.454 21.149 1.00 12.14 ? 362 GLN A N 1 ATOM 2560 C CA . GLN A 1 336 ? -31.519 -0.809 20.832 1.00 12.06 ? 362 GLN A CA 1 ATOM 2561 C C . GLN A 1 336 ? -30.628 -1.763 20.035 1.00 12.16 ? 362 GLN A C 1 ATOM 2562 O O . GLN A 1 336 ? -30.930 -2.958 19.941 1.00 11.91 ? 362 GLN A O 1 ATOM 2563 C CB . GLN A 1 336 ? -30.854 -0.310 22.113 1.00 12.07 ? 362 GLN A CB 1 ATOM 2564 C CG . GLN A 1 336 ? -31.641 0.826 22.752 1.00 12.11 ? 362 GLN A CG 1 ATOM 2565 C CD . GLN A 1 336 ? -31.088 1.289 24.089 1.00 12.28 ? 362 GLN A CD 1 ATOM 2566 O OE1 . GLN A 1 336 ? -30.700 0.481 24.926 1.00 12.65 ? 362 GLN A OE1 1 ATOM 2567 N NE2 . GLN A 1 336 ? -31.077 2.598 24.306 1.00 12.32 ? 362 GLN A NE2 1 ATOM 2568 N N . ARG A 1 337 ? -29.553 -1.242 19.436 1.00 12.11 ? 363 ARG A N 1 ATOM 2569 C CA . ARG A 1 337 ? -28.689 -2.067 18.583 1.00 12.02 ? 363 ARG A CA 1 ATOM 2570 C C . ARG A 1 337 ? -27.746 -2.922 19.428 1.00 11.97 ? 363 ARG A C 1 ATOM 2571 O O . ARG A 1 337 ? -26.552 -2.632 19.551 1.00 11.67 ? 363 ARG A O 1 ATOM 2572 C CB . ARG A 1 337 ? -27.896 -1.215 17.592 1.00 12.21 ? 363 ARG A CB 1 ATOM 2573 C CG . ARG A 1 337 ? -27.254 -2.031 16.479 1.00 12.30 ? 363 ARG A CG 1 ATOM 2574 C CD . ARG A 1 337 ? -25.894 -1.481 16.093 1.00 12.45 ? 363 ARG A CD 1 ATOM 2575 N NE . ARG A 1 337 ? -25.994 -0.136 15.523 1.00 12.52 ? 363 ARG A NE 1 ATOM 2576 C CZ . ARG A 1 337 ? -25.093 0.832 15.679 1.00 12.60 ? 363 ARG A CZ 1 ATOM 2577 N NH1 . ARG A 1 337 ? -25.300 2.014 15.116 1.00 12.87 ? 363 ARG A NH1 1 ATOM 2578 N NH2 . ARG A 1 337 ? -23.998 0.643 16.407 1.00 12.64 ? 363 ARG A NH2 1 ATOM 2579 N N . THR A 1 338 ? -28.308 -3.993 19.983 1.00 11.90 ? 364 THR A N 1 ATOM 2580 C CA . THR A 1 338 ? -27.626 -4.865 20.923 1.00 11.86 ? 364 THR A CA 1 ATOM 2581 C C . THR A 1 338 ? -27.843 -6.337 20.549 1.00 11.91 ? 364 THR A C 1 ATOM 2582 O O . THR A 1 338 ? -28.877 -6.698 19.984 1.00 12.35 ? 364 THR A O 1 ATOM 2583 C CB . THR A 1 338 ? -28.150 -4.641 22.363 1.00 11.83 ? 364 THR A CB 1 ATOM 2584 O OG1 . THR A 1 338 ? -29.511 -5.082 22.468 1.00 11.63 ? 364 THR A OG1 1 ATOM 2585 C CG2 . THR A 1 338 ? -28.076 -3.180 22.747 1.00 11.82 ? 364 THR A CG2 1 ATOM 2586 N N . LEU A 1 339 ? -26.863 -7.174 20.871 1.00 11.74 ? 365 LEU A N 1 ATOM 2587 C CA . LEU A 1 339 ? -26.981 -8.624 20.712 1.00 11.75 ? 365 LEU A CA 1 ATOM 2588 C C . LEU A 1 339 ? -27.838 -9.248 21.826 1.00 11.71 ? 365 LEU A C 1 ATOM 2589 O O . LEU A 1 339 ? -28.496 -10.269 21.615 1.00 11.34 ? 365 LEU A O 1 ATOM 2590 C CB . LEU A 1 339 ? -25.595 -9.275 20.707 1.00 11.63 ? 365 LEU A CB 1 ATOM 2591 C CG . LEU A 1 339 ? -24.708 -8.960 19.503 1.00 11.70 ? 365 LEU A CG 1 ATOM 2592 C CD1 . LEU A 1 339 ? -23.251 -9.286 19.813 1.00 11.83 ? 365 LEU A CD1 1 ATOM 2593 C CD2 . LEU A 1 339 ? -25.174 -9.706 18.263 1.00 11.66 ? 365 LEU A CD2 1 ATOM 2594 N N . THR A 1 340 ? -27.810 -8.642 23.011 1.00 11.81 ? 366 THR A N 1 ATOM 2595 C CA . THR A 1 340 ? -28.630 -9.109 24.135 1.00 11.97 ? 366 THR A CA 1 ATOM 2596 C C . THR A 1 340 ? -29.656 -8.060 24.561 1.00 11.99 ? 366 THR A C 1 ATOM 2597 O O . THR A 1 340 ? -29.478 -6.866 24.324 1.00 12.27 ? 366 THR A O 1 ATOM 2598 C CB . THR A 1 340 ? -27.765 -9.463 25.358 1.00 11.94 ? 366 THR A CB 1 ATOM 2599 O OG1 . THR A 1 340 ? -27.046 -8.299 25.785 1.00 11.98 ? 366 THR A OG1 1 ATOM 2600 C CG2 . THR A 1 340 ? -26.780 -10.574 25.022 1.00 11.94 ? 366 THR A CG2 1 ATOM 2601 N N . ALA A 1 341 ? -30.730 -8.520 25.187 1.00 12.06 ? 367 ALA A N 1 ATOM 2602 C CA . ALA A 1 341 ? -31.701 -7.639 25.815 1.00 12.21 ? 367 ALA A CA 1 ATOM 2603 C C . ALA A 1 341 ? -31.490 -7.698 27.322 1.00 12.34 ? 367 ALA A C 1 ATOM 2604 O O . ALA A 1 341 ? -31.654 -8.755 27.921 1.00 12.49 ? 367 ALA A O 1 ATOM 2605 C CB . ALA A 1 341 ? -33.116 -8.072 25.456 1.00 12.20 ? 367 ALA A CB 1 ATOM 2606 N N . ARG A 1 342 ? -31.123 -6.572 27.932 1.00 12.44 ? 368 ARG A N 1 ATOM 2607 C CA . ARG A 1 342 ? -30.873 -6.539 29.373 1.00 12.60 ? 368 ARG A CA 1 ATOM 2608 C C . ARG A 1 342 ? -32.115 -6.175 30.182 1.00 12.69 ? 368 ARG A C 1 ATOM 2609 O O . ARG A 1 342 ? -32.840 -5.230 29.861 1.00 12.52 ? 368 ARG A O 1 ATOM 2610 C CB . ARG A 1 342 ? -29.744 -5.563 29.726 1.00 12.68 ? 368 ARG A CB 1 ATOM 2611 C CG . ARG A 1 342 ? -29.534 -5.433 31.231 1.00 12.68 ? 368 ARG A CG 1 ATOM 2612 C CD . ARG A 1 342 ? -28.265 -4.692 31.602 1.00 12.75 ? 368 ARG A CD 1 ATOM 2613 N NE . ARG A 1 342 ? -28.236 -3.340 31.049 1.00 12.74 ? 368 ARG A NE 1 ATOM 2614 C CZ . ARG A 1 342 ? -27.411 -2.378 31.449 1.00 12.76 ? 368 ARG A CZ 1 ATOM 2615 N NH1 . ARG A 1 342 ? -26.539 -2.595 32.425 1.00 12.75 ? 368 ARG A NH1 1 ATOM 2616 N NH2 . ARG A 1 342 ? -27.466 -1.185 30.869 1.00 12.81 ? 368 ARG A NH2 1 ATOM 2617 N N . PHE A 1 343 ? -32.333 -6.933 31.249 1.00 12.86 ? 369 PHE A N 1 ATOM 2618 C CA . PHE A 1 343 ? -33.347 -6.615 32.233 1.00 13.10 ? 369 PHE A CA 1 ATOM 2619 C C . PHE A 1 343 ? -32.675 -6.473 33.590 1.00 13.44 ? 369 PHE A C 1 ATOM 2620 O O . PHE A 1 343 ? -32.155 -7.440 34.141 1.00 13.13 ? 369 PHE A O 1 ATOM 2621 C CB . PHE A 1 343 ? -34.421 -7.700 32.263 1.00 13.06 ? 369 PHE A CB 1 ATOM 2622 C CG . PHE A 1 343 ? -35.405 -7.596 31.140 1.00 12.88 ? 369 PHE A CG 1 ATOM 2623 C CD1 . PHE A 1 343 ? -35.154 -8.213 29.923 1.00 12.70 ? 369 PHE A CD1 1 ATOM 2624 C CD2 . PHE A 1 343 ? -36.575 -6.862 31.295 1.00 12.69 ? 369 PHE A CD2 1 ATOM 2625 C CE1 . PHE A 1 343 ? -36.058 -8.114 28.884 1.00 12.63 ? 369 PHE A CE1 1 ATOM 2626 C CE2 . PHE A 1 343 ? -37.481 -6.759 30.257 1.00 12.74 ? 369 PHE A CE2 1 ATOM 2627 C CZ . PHE A 1 343 ? -37.223 -7.385 29.051 1.00 12.62 ? 369 PHE A CZ 1 ATOM 2628 N N . GLN A 1 344 ? -32.658 -5.245 34.098 1.00 13.95 ? 370 GLN A N 1 ATOM 2629 C CA . GLN A 1 344 ? -32.204 -4.978 35.446 1.00 14.38 ? 370 GLN A CA 1 ATOM 2630 C C . GLN A 1 344 ? -33.398 -5.173 36.364 1.00 14.81 ? 370 GLN A C 1 ATOM 2631 O O . GLN A 1 344 ? -34.288 -4.319 36.425 1.00 14.88 ? 370 GLN A O 1 ATOM 2632 C CB . GLN A 1 344 ? -31.658 -3.560 35.552 1.00 14.55 ? 370 GLN A CB 1 ATOM 2633 C CG . GLN A 1 344 ? -30.350 -3.372 34.803 1.00 14.75 ? 370 GLN A CG 1 ATOM 2634 C CD . GLN A 1 344 ? -30.065 -1.918 34.509 1.00 14.97 ? 370 GLN A CD 1 ATOM 2635 O OE1 . GLN A 1 344 ? -30.835 -1.267 33.816 1.00 15.42 ? 370 GLN A OE1 1 ATOM 2636 N NE2 . GLN A 1 344 ? -28.961 -1.399 35.033 1.00 15.03 ? 370 GLN A NE2 1 ATOM 2637 N N . VAL A 1 345 ? -33.406 -6.310 37.062 1.00 15.20 ? 371 VAL A N 1 ATOM 2638 C CA . VAL A 1 345 ? -34.505 -6.703 37.939 1.00 15.35 ? 371 VAL A CA 1 ATOM 2639 C C . VAL A 1 345 ? -34.240 -6.141 39.337 1.00 15.66 ? 371 VAL A C 1 ATOM 2640 O O . VAL A 1 345 ? -33.493 -6.719 40.127 1.00 15.83 ? 371 VAL A O 1 ATOM 2641 C CB . VAL A 1 345 ? -34.666 -8.240 37.986 1.00 15.40 ? 371 VAL A CB 1 ATOM 2642 C CG1 . VAL A 1 345 ? -35.952 -8.626 38.705 1.00 15.30 ? 371 VAL A CG1 1 ATOM 2643 C CG2 . VAL A 1 345 ? -34.674 -8.817 36.579 1.00 15.46 ? 371 VAL A CG2 1 ATOM 2644 N N . ASN A 1 346 ? -34.867 -5.011 39.632 1.00 15.92 ? 372 ASN A N 1 ATOM 2645 C CA . ASN A 1 346 ? -34.588 -4.259 40.847 1.00 16.52 ? 372 ASN A CA 1 ATOM 2646 C C . ASN A 1 346 ? -35.471 -4.606 42.042 1.00 16.46 ? 372 ASN A C 1 ATOM 2647 O O . ASN A 1 346 ? -35.168 -4.195 43.153 1.00 16.51 ? 372 ASN A O 1 ATOM 2648 C CB . ASN A 1 346 ? -34.683 -2.760 40.549 1.00 17.06 ? 372 ASN A CB 1 ATOM 2649 C CG . ASN A 1 346 ? -33.700 -2.322 39.479 1.00 17.83 ? 372 ASN A CG 1 ATOM 2650 O OD1 . ASN A 1 346 ? -32.746 -3.041 39.163 1.00 17.97 ? 372 ASN A OD1 1 ATOM 2651 N ND2 . ASN A 1 346 ? -33.930 -1.136 38.909 1.00 18.59 ? 372 ASN A ND2 1 ATOM 2652 N N . ASN A 1 347 ? -36.541 -5.365 41.822 1.00 16.54 ? 373 ASN A N 1 ATOM 2653 C CA . ASN A 1 347 ? -37.448 -5.754 42.909 1.00 16.76 ? 373 ASN A CA 1 ATOM 2654 C C . ASN A 1 347 ? -37.109 -7.096 43.585 1.00 16.82 ? 373 ASN A C 1 ATOM 2655 O O . ASN A 1 347 ? -37.912 -7.608 44.361 1.00 17.80 ? 373 ASN A O 1 ATOM 2656 C CB . ASN A 1 347 ? -38.906 -5.765 42.417 1.00 16.65 ? 373 ASN A CB 1 ATOM 2657 C CG . ASN A 1 347 ? -39.137 -6.749 41.289 1.00 16.98 ? 373 ASN A CG 1 ATOM 2658 O OD1 . ASN A 1 347 ? -38.192 -7.227 40.662 1.00 17.43 ? 373 ASN A OD1 1 ATOM 2659 N ND2 . ASN A 1 347 ? -40.396 -7.044 41.012 1.00 16.89 ? 373 ASN A ND2 1 ATOM 2660 N N . THR A 1 348 ? -35.944 -7.671 43.292 1.00 16.59 ? 374 THR A N 1 ATOM 2661 C CA . THR A 1 348 ? -35.497 -8.880 43.988 1.00 16.33 ? 374 THR A CA 1 ATOM 2662 C C . THR A 1 348 ? -34.487 -8.504 45.063 1.00 16.43 ? 374 THR A C 1 ATOM 2663 O O . THR A 1 348 ? -33.992 -7.378 45.099 1.00 15.69 ? 374 THR A O 1 ATOM 2664 C CB . THR A 1 348 ? -34.855 -9.920 43.043 1.00 16.18 ? 374 THR A CB 1 ATOM 2665 O OG1 . THR A 1 348 ? -33.819 -9.308 42.264 1.00 15.55 ? 374 THR A OG1 1 ATOM 2666 C CG2 . THR A 1 348 ? -35.911 -10.542 42.113 1.00 16.30 ? 374 THR A CG2 1 ATOM 2667 N N . ARG A 1 349 ? -34.193 -9.470 45.929 1.00 16.49 ? 375 ARG A N 1 ATOM 2668 C CA . ARG A 1 349 ? -33.219 -9.314 46.991 1.00 16.77 ? 375 ARG A CA 1 ATOM 2669 C C . ARG A 1 349 ? -32.089 -10.332 46.868 1.00 16.56 ? 375 ARG A C 1 ATOM 2670 O O . ARG A 1 349 ? -32.284 -11.496 47.206 1.00 16.97 ? 375 ARG A O 1 ATOM 2671 C CB . ARG A 1 349 ? -33.881 -9.582 48.318 1.00 17.17 ? 375 ARG A CB 1 ATOM 2672 C CG . ARG A 1 349 ? -35.082 -8.731 48.652 1.00 17.67 ? 375 ARG A CG 1 ATOM 2673 C CD . ARG A 1 349 ? -35.146 -8.713 50.163 1.00 18.02 ? 375 ARG A CD 1 ATOM 2674 N NE . ARG A 1 349 ? -36.473 -8.876 50.685 1.00 18.19 ? 375 ARG A NE 1 ATOM 2675 C CZ . ARG A 1 349 ? -36.738 -9.131 51.957 1.00 18.01 ? 375 ARG A CZ 1 ATOM 2676 N NH1 . ARG A 1 349 ? -35.762 -9.248 52.854 1.00 18.10 ? 375 ARG A NH1 1 ATOM 2677 N NH2 . ARG A 1 349 ? -37.998 -9.262 52.325 1.00 18.10 ? 375 ARG A NH2 1 ATOM 2678 N N . PRO A 1 350 ? -30.904 -9.912 46.411 1.00 16.24 ? 376 PRO A N 1 ATOM 2679 C CA . PRO A 1 350 ? -30.537 -8.582 45.946 1.00 16.32 ? 376 PRO A CA 1 ATOM 2680 C C . PRO A 1 350 ? -31.107 -8.299 44.560 1.00 16.15 ? 376 PRO A C 1 ATOM 2681 O O . PRO A 1 350 ? -31.615 -9.216 43.909 1.00 16.00 ? 376 PRO A O 1 ATOM 2682 C CB . PRO A 1 350 ? -29.010 -8.655 45.883 1.00 16.41 ? 376 PRO A CB 1 ATOM 2683 C CG . PRO A 1 350 ? -28.733 -10.081 45.547 1.00 16.41 ? 376 PRO A CG 1 ATOM 2684 C CD . PRO A 1 350 ? -29.779 -10.859 46.296 1.00 16.30 ? 376 PRO A CD 1 ATOM 2685 N N . PRO A 1 351 ? -31.044 -7.031 44.112 1.00 15.87 ? 377 PRO A N 1 ATOM 2686 C CA . PRO A 1 351 ? -31.307 -6.761 42.703 1.00 15.83 ? 377 PRO A CA 1 ATOM 2687 C C . PRO A 1 351 ? -30.387 -7.615 41.834 1.00 15.61 ? 377 PRO A C 1 ATOM 2688 O O . PRO A 1 351 ? -29.285 -7.952 42.254 1.00 15.78 ? 377 PRO A O 1 ATOM 2689 C CB . PRO A 1 351 ? -30.957 -5.275 42.558 1.00 15.91 ? 377 PRO A CB 1 ATOM 2690 C CG . PRO A 1 351 ? -31.174 -4.709 43.924 1.00 15.92 ? 377 PRO A CG 1 ATOM 2691 C CD . PRO A 1 351 ? -30.772 -5.798 44.871 1.00 15.74 ? 377 PRO A CD 1 ATOM 2692 N N . HIS A 1 352 ? -30.844 -7.994 40.651 1.00 15.18 ? 378 HIS A N 1 ATOM 2693 C CA . HIS A 1 352 ? -30.016 -8.798 39.773 1.00 14.93 ? 378 HIS A CA 1 ATOM 2694 C C . HIS A 1 352 ? -30.261 -8.439 38.321 1.00 14.67 ? 378 HIS A C 1 ATOM 2695 O O . HIS A 1 352 ? -31.200 -7.710 37.999 1.00 14.80 ? 378 HIS A O 1 ATOM 2696 C CB . HIS A 1 352 ? -30.263 -10.288 40.017 1.00 14.65 ? 378 HIS A CB 1 ATOM 2697 C CG . HIS A 1 352 ? -31.558 -10.793 39.458 1.00 14.69 ? 378 HIS A CG 1 ATOM 2698 N ND1 . HIS A 1 352 ? -32.748 -10.719 40.149 1.00 14.59 ? 378 HIS A ND1 1 ATOM 2699 C CD2 . HIS A 1 352 ? -31.842 -11.404 38.282 1.00 14.62 ? 378 HIS A CD2 1 ATOM 2700 C CE1 . HIS A 1 352 ? -33.712 -11.252 39.419 1.00 14.68 ? 378 HIS A CE1 1 ATOM 2701 N NE2 . HIS A 1 352 ? -33.189 -11.676 38.282 1.00 14.77 ? 378 HIS A NE2 1 ATOM 2702 N N . VAL A 1 353 ? -29.403 -8.965 37.457 1.00 14.39 ? 379 VAL A N 1 ATOM 2703 C CA . VAL A 1 353 ? -29.462 -8.700 36.028 1.00 14.46 ? 379 VAL A CA 1 ATOM 2704 C C . VAL A 1 353 ? -29.781 -9.988 35.277 1.00 13.90 ? 379 VAL A C 1 ATOM 2705 O O . VAL A 1 353 ? -29.301 -11.059 35.637 1.00 13.49 ? 379 VAL A O 1 ATOM 2706 C CB . VAL A 1 353 ? -28.118 -8.146 35.515 1.00 14.76 ? 379 VAL A CB 1 ATOM 2707 C CG1 . VAL A 1 353 ? -28.275 -7.596 34.106 1.00 14.90 ? 379 VAL A CG1 1 ATOM 2708 C CG2 . VAL A 1 353 ? -27.610 -7.065 36.455 1.00 15.09 ? 379 VAL A CG2 1 ATOM 2709 N N . GLN A 1 354 ? -30.609 -9.864 34.245 1.00 13.74 ? 380 GLN A N 1 ATOM 2710 C CA . GLN A 1 354 ? -30.938 -10.965 33.343 1.00 13.38 ? 380 GLN A CA 1 ATOM 2711 C C . GLN A 1 354 ? -30.709 -10.494 31.916 1.00 13.17 ? 380 GLN A C 1 ATOM 2712 O O . GLN A 1 354 ? -31.091 -9.373 31.565 1.00 12.85 ? 380 GLN A O 1 ATOM 2713 C CB . GLN A 1 354 ? -32.398 -11.381 33.517 1.00 13.40 ? 380 GLN A CB 1 ATOM 2714 C CG . GLN A 1 354 ? -32.708 -12.091 34.829 1.00 13.41 ? 380 GLN A CG 1 ATOM 2715 C CD . GLN A 1 354 ? -32.121 -13.492 34.911 1.00 13.32 ? 380 GLN A CD 1 ATOM 2716 O OE1 . GLN A 1 354 ? -31.633 -14.035 33.917 1.00 13.18 ? 380 GLN A OE1 1 ATOM 2717 N NE2 . GLN A 1 354 ? -32.168 -14.087 36.102 1.00 13.13 ? 380 GLN A NE2 1 ATOM 2718 N N . LEU A 1 355 ? -30.076 -11.338 31.100 1.00 12.99 ? 381 LEU A N 1 ATOM 2719 C CA . LEU A 1 355 ? -29.944 -11.061 29.672 1.00 12.94 ? 381 LEU A CA 1 ATOM 2720 C C . LEU A 1 355 ? -30.717 -12.076 28.847 1.00 13.25 ? 381 LEU A C 1 ATOM 2721 O O . LEU A 1 355 ? -30.732 -13.273 29.155 1.00 13.55 ? 381 LEU A O 1 ATOM 2722 C CB . LEU A 1 355 ? -28.481 -11.081 29.229 1.00 12.76 ? 381 LEU A CB 1 ATOM 2723 C CG . LEU A 1 355 ? -27.501 -10.116 29.891 1.00 12.70 ? 381 LEU A CG 1 ATOM 2724 C CD1 . LEU A 1 355 ? -26.146 -10.251 29.208 1.00 12.75 ? 381 LEU A CD1 1 ATOM 2725 C CD2 . LEU A 1 355 ? -27.983 -8.672 29.847 1.00 12.55 ? 381 LEU A CD2 1 ATOM 2726 N N . LEU A 1 356 ? -31.350 -11.589 27.787 1.00 13.45 ? 382 LEU A N 1 ATOM 2727 C CA . LEU A 1 356 ? -31.939 -12.456 26.789 1.00 13.65 ? 382 LEU A CA 1 ATOM 2728 C C . LEU A 1 356 ? -31.179 -12.328 25.479 1.00 13.47 ? 382 LEU A C 1 ATOM 2729 O O . LEU A 1 356 ? -30.690 -11.256 25.109 1.00 13.36 ? 382 LEU A O 1 ATOM 2730 C CB . LEU A 1 356 ? -33.427 -12.149 26.589 1.00 14.17 ? 382 LEU A CB 1 ATOM 2731 C CG . LEU A 1 356 ? -34.288 -12.586 27.781 1.00 14.37 ? 382 LEU A CG 1 ATOM 2732 C CD1 . LEU A 1 356 ? -34.450 -11.443 28.771 1.00 14.59 ? 382 LEU A CD1 1 ATOM 2733 C CD2 . LEU A 1 356 ? -35.640 -13.065 27.323 1.00 14.67 ? 382 LEU A CD2 1 ATOM 2734 N N . ARG A 1 357 ? -31.078 -13.456 24.803 1.00 13.16 ? 383 ARG A N 1 ATOM 2735 C CA . ARG A 1 357 ? -30.459 -13.561 23.502 1.00 12.98 ? 383 ARG A CA 1 ATOM 2736 C C . ARG A 1 357 ? -31.451 -13.111 22.433 1.00 12.51 ? 383 ARG A C 1 ATOM 2737 O O . ARG A 1 357 ? -32.525 -13.705 22.274 1.00 12.54 ? 383 ARG A O 1 ATOM 2738 C CB . ARG A 1 357 ? -30.079 -15.020 23.313 1.00 13.35 ? 383 ARG A CB 1 ATOM 2739 C CG . ARG A 1 357 ? -29.506 -15.451 21.979 1.00 13.73 ? 383 ARG A CG 1 ATOM 2740 C CD . ARG A 1 357 ? -29.057 -16.899 22.147 1.00 14.21 ? 383 ARG A CD 1 ATOM 2741 N NE . ARG A 1 357 ? -29.612 -17.733 21.102 1.00 14.91 ? 383 ARG A NE 1 ATOM 2742 C CZ . ARG A 1 357 ? -29.992 -18.993 21.238 1.00 14.80 ? 383 ARG A CZ 1 ATOM 2743 N NH1 . ARG A 1 357 ? -29.909 -19.638 22.399 1.00 14.89 ? 383 ARG A NH1 1 ATOM 2744 N NH2 . ARG A 1 357 ? -30.470 -19.606 20.176 1.00 15.40 ? 383 ARG A NH2 1 ATOM 2745 N N . LYS A 1 358 ? -31.094 -12.056 21.710 1.00 11.86 ? 384 LYS A N 1 ATOM 2746 C CA . LYS A 1 358 ? -31.961 -11.506 20.674 1.00 11.52 ? 384 LYS A CA 1 ATOM 2747 C C . LYS A 1 358 ? -31.711 -12.239 19.357 1.00 11.34 ? 384 LYS A C 1 ATOM 2748 O O . LYS A 1 358 ? -30.645 -12.829 19.175 1.00 11.33 ? 384 LYS A O 1 ATOM 2749 C CB . LYS A 1 358 ? -31.710 -10.007 20.504 1.00 11.30 ? 384 LYS A CB 1 ATOM 2750 C CG . LYS A 1 358 ? -32.154 -9.161 21.693 1.00 11.27 ? 384 LYS A CG 1 ATOM 2751 C CD . LYS A 1 358 ? -31.717 -7.701 21.585 1.00 11.21 ? 384 LYS A CD 1 ATOM 2752 C CE . LYS A 1 358 ? -32.115 -7.056 20.262 1.00 11.15 ? 384 LYS A CE 1 ATOM 2753 N NZ . LYS A 1 358 ? -31.663 -5.646 20.165 1.00 11.08 ? 384 LYS A NZ 1 ATOM 2754 N N . PRO A 1 359 ? -32.689 -12.210 18.434 1.00 11.16 ? 385 PRO A N 1 ATOM 2755 C CA . PRO A 1 359 ? -32.546 -12.969 17.191 1.00 11.26 ? 385 PRO A CA 1 ATOM 2756 C C . PRO A 1 359 ? -31.296 -12.649 16.379 1.00 11.22 ? 385 PRO A C 1 ATOM 2757 O O . PRO A 1 359 ? -30.772 -13.527 15.698 1.00 11.17 ? 385 PRO A O 1 ATOM 2758 C CB . PRO A 1 359 ? -33.806 -12.596 16.413 1.00 11.24 ? 385 PRO A CB 1 ATOM 2759 C CG . PRO A 1 359 ? -34.812 -12.360 17.479 1.00 11.32 ? 385 PRO A CG 1 ATOM 2760 C CD . PRO A 1 359 ? -34.043 -11.647 18.561 1.00 11.26 ? 385 PRO A CD 1 ATOM 2761 N N . VAL A 1 360 ? -30.833 -11.404 16.444 1.00 11.32 ? 386 VAL A N 1 ATOM 2762 C CA . VAL A 1 360 ? -29.606 -11.030 15.755 1.00 11.39 ? 386 VAL A CA 1 ATOM 2763 C C . VAL A 1 360 ? -28.444 -11.895 16.248 1.00 11.40 ? 386 VAL A C 1 ATOM 2764 O O . VAL A 1 360 ? -27.669 -12.378 15.442 1.00 11.60 ? 386 VAL A O 1 ATOM 2765 C CB . VAL A 1 360 ? -29.300 -9.508 15.840 1.00 11.31 ? 386 VAL A CB 1 ATOM 2766 C CG1 . VAL A 1 360 ? -29.095 -9.037 17.274 1.00 11.33 ? 386 VAL A CG1 1 ATOM 2767 C CG2 . VAL A 1 360 ? -28.089 -9.162 14.988 1.00 11.35 ? 386 VAL A CG2 1 ATOM 2768 N N . LEU A 1 361 ? -28.355 -12.120 17.556 1.00 11.56 ? 387 LEU A N 1 ATOM 2769 C CA . LEU A 1 361 ? -27.310 -12.982 18.133 1.00 11.56 ? 387 LEU A CA 1 ATOM 2770 C C . LEU A 1 361 ? -27.508 -14.439 17.729 1.00 11.42 ? 387 LEU A C 1 ATOM 2771 O O . LEU A 1 361 ? -26.543 -15.139 17.432 1.00 11.31 ? 387 LEU A O 1 ATOM 2772 C CB . LEU A 1 361 ? -27.290 -12.872 19.663 1.00 11.76 ? 387 LEU A CB 1 ATOM 2773 C CG . LEU A 1 361 ? -26.248 -13.705 20.432 1.00 11.86 ? 387 LEU A CG 1 ATOM 2774 C CD1 . LEU A 1 361 ? -24.830 -13.487 19.918 1.00 11.97 ? 387 LEU A CD1 1 ATOM 2775 C CD2 . LEU A 1 361 ? -26.302 -13.359 21.906 1.00 11.92 ? 387 LEU A CD2 1 ATOM 2776 N N . THR A 1 362 ? -28.758 -14.891 17.723 1.00 11.36 ? 388 THR A N 1 ATOM 2777 C CA . THR A 1 362 ? -29.081 -16.243 17.263 1.00 11.32 ? 388 THR A CA 1 ATOM 2778 C C . THR A 1 362 ? -28.679 -16.428 15.797 1.00 11.34 ? 388 THR A C 1 ATOM 2779 O O . THR A 1 362 ? -28.103 -17.454 15.435 1.00 11.47 ? 388 THR A O 1 ATOM 2780 C CB . THR A 1 362 ? -30.574 -16.560 17.469 1.00 11.31 ? 388 THR A CB 1 ATOM 2781 O OG1 . THR A 1 362 ? -30.852 -16.605 18.871 1.00 11.37 ? 388 THR A OG1 1 ATOM 2782 C CG2 . THR A 1 362 ? -30.964 -17.905 16.835 1.00 11.31 ? 388 THR A CG2 1 ATOM 2783 N N . ALA A 1 363 ? -28.953 -15.421 14.967 1.00 11.29 ? 389 ALA A N 1 ATOM 2784 C CA . ALA A 1 363 ? -28.579 -15.461 13.548 1.00 11.17 ? 389 ALA A CA 1 ATOM 2785 C C . ALA A 1 363 ? -27.074 -15.617 13.322 1.00 11.19 ? 389 ALA A C 1 ATOM 2786 O O . ALA A 1 363 ? -26.654 -16.221 12.333 1.00 11.13 ? 389 ALA A O 1 ATOM 2787 C CB . ALA A 1 363 ? -29.090 -14.219 12.826 1.00 11.21 ? 389 ALA A CB 1 ATOM 2788 N N . MET A 1 364 ? -26.260 -15.078 14.224 1.00 11.25 ? 390 MET A N 1 ATOM 2789 C CA . MET A 1 364 ? -24.808 -15.211 14.092 1.00 11.43 ? 390 MET A CA 1 ATOM 2790 C C . MET A 1 364 ? -24.389 -16.675 14.231 1.00 11.28 ? 390 MET A C 1 ATOM 2791 O O . MET A 1 364 ? -23.413 -17.103 13.616 1.00 11.24 ? 390 MET A O 1 ATOM 2792 C CB . MET A 1 364 ? -24.071 -14.337 15.119 1.00 11.76 ? 390 MET A CB 1 ATOM 2793 C CG . MET A 1 364 ? -24.306 -12.838 14.963 1.00 11.90 ? 390 MET A CG 1 ATOM 2794 S SD . MET A 1 364 ? -23.791 -12.142 13.381 1.00 12.47 ? 390 MET A SD 1 ATOM 2795 C CE . MET A 1 364 ? -22.040 -11.890 13.648 1.00 12.32 ? 390 MET A CE 1 ATOM 2796 N N . GLY A 1 365 ? -25.140 -17.437 15.025 1.00 11.19 ? 391 GLY A N 1 ATOM 2797 C CA . GLY A 1 365 ? -24.942 -18.878 15.142 1.00 11.23 ? 391 GLY A CA 1 ATOM 2798 C C . GLY A 1 365 ? -25.284 -19.643 13.873 1.00 11.24 ? 391 GLY A C 1 ATOM 2799 O O . GLY A 1 365 ? -24.654 -20.658 13.564 1.00 11.27 ? 391 GLY A O 1 ATOM 2800 N N . LEU A 1 366 ? -26.284 -19.160 13.139 1.00 11.24 ? 392 LEU A N 1 ATOM 2801 C CA . LEU A 1 366 ? -26.674 -19.758 11.863 1.00 11.20 ? 392 LEU A CA 1 ATOM 2802 C C . LEU A 1 366 ? -25.635 -19.469 10.779 1.00 11.22 ? 392 LEU A C 1 ATOM 2803 O O . LEU A 1 366 ? -25.275 -20.353 10.001 1.00 10.92 ? 392 LEU A O 1 ATOM 2804 C CB . LEU A 1 366 ? -28.057 -19.246 11.434 1.00 11.24 ? 392 LEU A CB 1 ATOM 2805 C CG . LEU A 1 366 ? -29.219 -19.642 12.352 1.00 11.29 ? 392 LEU A CG 1 ATOM 2806 C CD1 . LEU A 1 366 ? -30.518 -19.014 11.869 1.00 11.34 ? 392 LEU A CD1 1 ATOM 2807 C CD2 . LEU A 1 366 ? -29.371 -21.153 12.446 1.00 11.31 ? 392 LEU A CD2 1 ATOM 2808 N N . LEU A 1 367 ? -25.167 -18.223 10.738 1.00 11.47 ? 393 LEU A N 1 ATOM 2809 C CA . LEU A 1 367 ? -24.051 -17.824 9.880 1.00 11.75 ? 393 LEU A CA 1 ATOM 2810 C C . LEU A 1 367 ? -22.788 -18.631 10.174 1.00 12.08 ? 393 LEU A C 1 ATOM 2811 O O . LEU A 1 367 ? -22.029 -18.947 9.263 1.00 11.95 ? 393 LEU A O 1 ATOM 2812 C CB . LEU A 1 367 ? -23.743 -16.336 10.065 1.00 11.76 ? 393 LEU A CB 1 ATOM 2813 C CG . LEU A 1 367 ? -24.717 -15.380 9.377 1.00 11.77 ? 393 LEU A CG 1 ATOM 2814 C CD1 . LEU A 1 367 ? -24.713 -14.015 10.057 1.00 11.85 ? 393 LEU A CD1 1 ATOM 2815 C CD2 . LEU A 1 367 ? -24.376 -15.262 7.896 1.00 11.71 ? 393 LEU A CD2 1 ATOM 2816 N N . ALA A 1 368 ? -22.575 -18.966 11.445 1.00 12.43 ? 394 ALA A N 1 ATOM 2817 C CA . ALA A 1 368 ? -21.388 -19.720 11.849 1.00 12.87 ? 394 ALA A CA 1 ATOM 2818 C C . ALA A 1 368 ? -21.339 -21.131 11.255 1.00 13.28 ? 394 ALA A C 1 ATOM 2819 O O . ALA A 1 368 ? -20.261 -21.705 11.132 1.00 13.19 ? 394 ALA A O 1 ATOM 2820 C CB . ALA A 1 368 ? -21.290 -19.781 13.364 1.00 12.94 ? 394 ALA A CB 1 ATOM 2821 N N . LEU A 1 369 ? -22.498 -21.675 10.873 1.00 13.90 ? 395 LEU A N 1 ATOM 2822 C CA . LEU A 1 369 ? -22.564 -23.001 10.253 1.00 14.34 ? 395 LEU A CA 1 ATOM 2823 C C . LEU A 1 369 ? -22.089 -23.007 8.798 1.00 14.79 ? 395 LEU A C 1 ATOM 2824 O O . LEU A 1 369 ? -21.811 -24.072 8.255 1.00 14.71 ? 395 LEU A O 1 ATOM 2825 C CB . LEU A 1 369 ? -23.982 -23.586 10.343 1.00 14.63 ? 395 LEU A CB 1 ATOM 2826 C CG . LEU A 1 369 ? -24.411 -24.176 11.687 1.00 14.72 ? 395 LEU A CG 1 ATOM 2827 C CD1 . LEU A 1 369 ? -25.910 -24.434 11.724 1.00 14.97 ? 395 LEU A CD1 1 ATOM 2828 C CD2 . LEU A 1 369 ? -23.662 -25.470 11.966 1.00 14.89 ? 395 LEU A CD2 1 ATOM 2829 N N . LEU A 1 370 ? -21.986 -21.836 8.167 1.00 15.26 ? 396 LEU A N 1 ATOM 2830 C CA . LEU A 1 370 ? -21.453 -21.758 6.807 1.00 15.70 ? 396 LEU A CA 1 ATOM 2831 C C . LEU A 1 370 ? -20.020 -22.277 6.781 1.00 16.26 ? 396 LEU A C 1 ATOM 2832 O O . LEU A 1 370 ? -19.224 -21.975 7.673 1.00 16.12 ? 396 LEU A O 1 ATOM 2833 C CB . LEU A 1 370 ? -21.509 -20.328 6.262 1.00 15.74 ? 396 LEU A CB 1 ATOM 2834 C CG . LEU A 1 370 ? -22.907 -19.769 5.982 1.00 15.73 ? 396 LEU A CG 1 ATOM 2835 C CD1 . LEU A 1 370 ? -22.836 -18.277 5.690 1.00 15.76 ? 396 LEU A CD1 1 ATOM 2836 C CD2 . LEU A 1 370 ? -23.589 -20.502 4.837 1.00 15.79 ? 396 LEU A CD2 1 ATOM 2837 N N . ASP A 1 371 ? -19.706 -23.074 5.766 1.00 17.04 ? 397 ASP A N 1 ATOM 2838 C CA . ASP A 1 371 ? -18.400 -23.719 5.665 1.00 17.70 ? 397 ASP A CA 1 ATOM 2839 C C . ASP A 1 371 ? -17.532 -23.072 4.588 1.00 17.83 ? 397 ASP A C 1 ATOM 2840 O O . ASP A 1 371 ? -17.937 -22.094 3.972 1.00 17.57 ? 397 ASP A O 1 ATOM 2841 C CB . ASP A 1 371 ? -18.587 -25.219 5.452 1.00 18.16 ? 397 ASP A CB 1 ATOM 2842 C CG . ASP A 1 371 ? -19.141 -25.908 6.688 1.00 18.70 ? 397 ASP A CG 1 ATOM 2843 O OD1 . ASP A 1 371 ? -18.685 -25.586 7.806 1.00 18.92 ? 397 ASP A OD1 1 ATOM 2844 O OD2 . ASP A 1 371 ? -20.025 -26.778 6.547 1.00 19.38 ? 397 ASP A OD2 1 ATOM 2845 N N . GLU A 1 372 ? -16.341 -23.622 4.373 1.00 18.54 ? 398 GLU A N 1 ATOM 2846 C CA . GLU A 1 372 ? -15.243 -22.875 3.751 1.00 19.24 ? 398 GLU A CA 1 ATOM 2847 C C . GLU A 1 372 ? -15.341 -22.636 2.238 1.00 19.90 ? 398 GLU A C 1 ATOM 2848 O O . GLU A 1 372 ? -14.584 -21.828 1.698 1.00 20.63 ? 398 GLU A O 1 ATOM 2849 C CB . GLU A 1 372 ? -13.889 -23.513 4.117 1.00 19.42 ? 398 GLU A CB 1 ATOM 2850 C CG . GLU A 1 372 ? -13.565 -24.845 3.436 1.00 19.79 ? 398 GLU A CG 1 ATOM 2851 C CD . GLU A 1 372 ? -14.251 -26.060 4.055 1.00 20.19 ? 398 GLU A CD 1 ATOM 2852 O OE1 . GLU A 1 372 ? -14.974 -25.922 5.071 1.00 19.70 ? 398 GLU A OE1 1 ATOM 2853 O OE2 . GLU A 1 372 ? -14.063 -27.172 3.510 1.00 20.99 ? 398 GLU A OE2 1 ATOM 2854 N N . GLU A 1 373 ? -16.260 -23.312 1.556 1.00 20.29 ? 399 GLU A N 1 ATOM 2855 C CA . GLU A 1 373 ? -16.388 -23.164 0.105 1.00 20.57 ? 399 GLU A CA 1 ATOM 2856 C C . GLU A 1 373 ? -17.803 -22.796 -0.315 1.00 19.31 ? 399 GLU A C 1 ATOM 2857 O O . GLU A 1 373 ? -18.766 -23.430 0.107 1.00 18.78 ? 399 GLU A O 1 ATOM 2858 C CB . GLU A 1 373 ? -15.920 -24.440 -0.600 1.00 22.06 ? 399 GLU A CB 1 ATOM 2859 C CG . GLU A 1 373 ? -14.435 -24.387 -0.967 1.00 23.63 ? 399 GLU A CG 1 ATOM 2860 C CD . GLU A 1 373 ? -13.767 -25.742 -0.998 1.00 24.53 ? 399 GLU A CD 1 ATOM 2861 O OE1 . GLU A 1 373 ? -14.273 -26.675 -0.331 1.00 26.17 ? 399 GLU A OE1 1 ATOM 2862 O OE2 . GLU A 1 373 ? -12.726 -25.865 -1.680 1.00 24.92 ? 399 GLU A OE2 1 ATOM 2863 N N . GLN A 1 374 ? -17.918 -21.758 -1.138 1.00 18.16 ? 400 GLN A N 1 ATOM 2864 C CA . GLN A 1 374 ? -19.220 -21.297 -1.590 1.00 17.76 ? 400 GLN A CA 1 ATOM 2865 C C . GLN A 1 374 ? -19.718 -22.163 -2.741 1.00 17.25 ? 400 GLN A C 1 ATOM 2866 O O . GLN A 1 374 ? -18.961 -22.483 -3.659 1.00 17.09 ? 400 GLN A O 1 ATOM 2867 C CB . GLN A 1 374 ? -19.181 -19.830 -2.030 1.00 17.43 ? 400 GLN A CB 1 ATOM 2868 C CG . GLN A 1 374 ? -20.550 -19.323 -2.459 1.00 17.40 ? 400 GLN A CG 1 ATOM 2869 C CD . GLN A 1 374 ? -20.606 -17.826 -2.658 1.00 17.48 ? 400 GLN A CD 1 ATOM 2870 O OE1 . GLN A 1 374 ? -19.584 -17.172 -2.875 1.00 17.58 ? 400 GLN A OE1 1 ATOM 2871 N NE2 . GLN A 1 374 ? -21.812 -17.273 -2.604 1.00 17.58 ? 400 GLN A NE2 1 ATOM 2872 N N . LEU A 1 375 ? -20.996 -22.525 -2.680 1.00 16.77 ? 401 LEU A N 1 ATOM 2873 C CA . LEU A 1 375 ? -21.645 -23.300 -3.731 1.00 16.58 ? 401 LEU A CA 1 ATOM 2874 C C . LEU A 1 375 ? -22.391 -22.376 -4.682 1.00 16.67 ? 401 LEU A C 1 ATOM 2875 O O . LEU A 1 375 ? -22.816 -21.280 -4.302 1.00 16.57 ? 401 LEU A O 1 ATOM 2876 C CB . LEU A 1 375 ? -22.633 -24.301 -3.133 1.00 16.31 ? 401 LEU A CB 1 ATOM 2877 C CG . LEU A 1 375 ? -22.047 -25.404 -2.248 1.00 16.16 ? 401 LEU A CG 1 ATOM 2878 C CD1 . LEU A 1 375 ? -23.170 -26.148 -1.531 1.00 16.02 ? 401 LEU A CD1 1 ATOM 2879 C CD2 . LEU A 1 375 ? -21.181 -26.359 -3.070 1.00 15.94 ? 401 LEU A CD2 1 ATOM 2880 N N . TRP A 1 376 ? -22.544 -22.825 -5.922 1.00 16.85 ? 402 TRP A N 1 ATOM 2881 C CA . TRP A 1 376 ? -23.388 -22.132 -6.875 1.00 16.85 ? 402 TRP A CA 1 ATOM 2882 C C . TRP A 1 376 ? -24.827 -22.135 -6.361 1.00 16.77 ? 402 TRP A C 1 ATOM 2883 O O . TRP A 1 376 ? -25.342 -23.172 -5.930 1.00 15.94 ? 402 TRP A O 1 ATOM 2884 C CB . TRP A 1 376 ? -23.318 -22.794 -8.255 1.00 17.06 ? 402 TRP A CB 1 ATOM 2885 C CG . TRP A 1 376 ? -24.152 -22.102 -9.289 1.00 17.05 ? 402 TRP A CG 1 ATOM 2886 C CD1 . TRP A 1 376 ? -23.764 -21.078 -10.106 1.00 17.03 ? 402 TRP A CD1 1 ATOM 2887 C CD2 . TRP A 1 376 ? -25.520 -22.375 -9.613 1.00 17.16 ? 402 TRP A CD2 1 ATOM 2888 N NE1 . TRP A 1 376 ? -24.806 -20.695 -10.913 1.00 17.05 ? 402 TRP A NE1 1 ATOM 2889 C CE2 . TRP A 1 376 ? -25.896 -21.475 -10.633 1.00 17.11 ? 402 TRP A CE2 1 ATOM 2890 C CE3 . TRP A 1 376 ? -26.467 -23.287 -9.136 1.00 17.17 ? 402 TRP A CE3 1 ATOM 2891 C CZ2 . TRP A 1 376 ? -27.175 -21.466 -11.191 1.00 17.12 ? 402 TRP A CZ2 1 ATOM 2892 C CZ3 . TRP A 1 376 ? -27.741 -23.276 -9.693 1.00 17.34 ? 402 TRP A CZ3 1 ATOM 2893 C CH2 . TRP A 1 376 ? -28.081 -22.370 -10.710 1.00 17.00 ? 402 TRP A CH2 1 ATOM 2894 N N . ALA A 1 377 ? -25.453 -20.961 -6.389 1.00 16.77 ? 403 ALA A N 1 ATOM 2895 C CA . ALA A 1 377 ? -26.871 -20.833 -6.099 1.00 16.96 ? 403 ALA A CA 1 ATOM 2896 C C . ALA A 1 377 ? -27.498 -19.760 -6.982 1.00 17.42 ? 403 ALA A C 1 ATOM 2897 O O . ALA A 1 377 ? -26.810 -18.858 -7.454 1.00 17.60 ? 403 ALA A O 1 ATOM 2898 C CB . ALA A 1 377 ? -27.088 -20.506 -4.632 1.00 16.97 ? 403 ALA A CB 1 ATOM 2899 N N . GLU A 1 378 ? -28.806 -19.861 -7.194 1.00 18.07 ? 404 GLU A N 1 ATOM 2900 C CA . GLU A 1 378 ? -29.540 -18.884 -7.995 1.00 18.78 ? 404 GLU A CA 1 ATOM 2901 C C . GLU A 1 378 ? -30.953 -18.705 -7.457 1.00 18.87 ? 404 GLU A C 1 ATOM 2902 O O . GLU A 1 378 ? -31.706 -19.675 -7.315 1.00 18.54 ? 404 GLU A O 1 ATOM 2903 C CB . GLU A 1 378 ? -29.596 -19.332 -9.456 1.00 19.41 ? 404 GLU A CB 1 ATOM 2904 C CG . GLU A 1 378 ? -30.130 -18.288 -10.421 1.00 19.92 ? 404 GLU A CG 1 ATOM 2905 C CD . GLU A 1 378 ? -30.552 -18.894 -11.742 1.00 20.41 ? 404 GLU A CD 1 ATOM 2906 O OE1 . GLU A 1 378 ? -29.764 -18.834 -12.698 1.00 20.74 ? 404 GLU A OE1 1 ATOM 2907 O OE2 . GLU A 1 378 ? -31.664 -19.455 -11.819 1.00 21.26 ? 404 GLU A OE2 1 ATOM 2908 N N . VAL A 1 379 ? -31.290 -17.457 -7.146 1.00 19.19 ? 405 VAL A N 1 ATOM 2909 C CA . VAL A 1 379 ? -32.640 -17.073 -6.771 1.00 19.24 ? 405 VAL A CA 1 ATOM 2910 C C . VAL A 1 379 ? -33.320 -16.485 -7.999 1.00 19.48 ? 405 VAL A C 1 ATOM 2911 O O . VAL A 1 379 ? -32.742 -15.636 -8.679 1.00 19.36 ? 405 VAL A O 1 ATOM 2912 C CB . VAL A 1 379 ? -32.630 -16.001 -5.664 1.00 19.20 ? 405 VAL A CB 1 ATOM 2913 C CG1 . VAL A 1 379 ? -34.053 -15.644 -5.242 1.00 19.03 ? 405 VAL A CG1 1 ATOM 2914 C CG2 . VAL A 1 379 ? -31.813 -16.476 -4.472 1.00 19.21 ? 405 VAL A CG2 1 ATOM 2915 N N . SER A 1 380 ? -34.548 -16.922 -8.269 1.00 20.05 ? 406 SER A N 1 ATOM 2916 C CA . SER A 1 380 ? -35.330 -16.379 -9.378 1.00 20.25 ? 406 SER A CA 1 ATOM 2917 C C . SER A 1 380 ? -36.808 -16.264 -9.022 1.00 20.72 ? 406 SER A C 1 ATOM 2918 O O . SER A 1 380 ? -37.298 -16.943 -8.117 1.00 20.05 ? 406 SER A O 1 ATOM 2919 C CB . SER A 1 380 ? -35.168 -17.244 -10.631 1.00 20.09 ? 406 SER A CB 1 ATOM 2920 O OG . SER A 1 380 ? -35.756 -18.520 -10.445 1.00 20.18 ? 406 SER A OG 1 ATOM 2921 N N . GLN A 1 381 ? -37.498 -15.387 -9.747 1.00 21.34 ? 407 GLN A N 1 ATOM 2922 C CA . GLN A 1 381 ? -38.944 -15.214 -9.629 1.00 22.14 ? 407 GLN A CA 1 ATOM 2923 C C . GLN A 1 381 ? -39.533 -15.013 -11.025 1.00 22.20 ? 407 GLN A C 1 ATOM 2924 O O . GLN A 1 381 ? -39.094 -14.124 -11.764 1.00 21.93 ? 407 GLN A O 1 ATOM 2925 C CB . GLN A 1 381 ? -39.257 -14.003 -8.758 1.00 22.69 ? 407 GLN A CB 1 ATOM 2926 C CG . GLN A 1 381 ? -40.721 -13.849 -8.371 1.00 23.22 ? 407 GLN A CG 1 ATOM 2927 C CD . GLN A 1 381 ? -40.977 -12.560 -7.609 1.00 23.59 ? 407 GLN A CD 1 ATOM 2928 O OE1 . GLN A 1 381 ? -40.348 -11.536 -7.875 1.00 24.18 ? 407 GLN A OE1 1 ATOM 2929 N NE2 . GLN A 1 381 ? -41.904 -12.601 -6.661 1.00 24.07 ? 407 GLN A NE2 1 ATOM 2930 N N . ALA A 1 382 ? -40.514 -15.842 -11.383 1.00 21.94 ? 408 ALA A N 1 ATOM 2931 C CA . ALA A 1 382 ? -41.149 -15.787 -12.700 1.00 22.22 ? 408 ALA A CA 1 ATOM 2932 C C . ALA A 1 382 ? -40.107 -15.732 -13.826 1.00 22.13 ? 408 ALA A C 1 ATOM 2933 O O . ALA A 1 382 ? -40.273 -15.014 -14.812 1.00 21.95 ? 408 ALA A O 1 ATOM 2934 C CB . ALA A 1 382 ? -42.093 -14.592 -12.777 1.00 22.19 ? 408 ALA A CB 1 ATOM 2935 N N . GLY A 1 383 ? -39.025 -16.489 -13.656 1.00 22.09 ? 409 GLY A N 1 ATOM 2936 C CA . GLY A 1 383 ? -37.960 -16.563 -14.652 1.00 22.07 ? 409 GLY A CA 1 ATOM 2937 C C . GLY A 1 383 ? -36.923 -15.453 -14.619 1.00 21.96 ? 409 GLY A C 1 ATOM 2938 O O . GLY A 1 383 ? -35.948 -15.521 -15.361 1.00 22.49 ? 409 GLY A O 1 ATOM 2939 N N . THR A 1 384 ? -37.114 -14.434 -13.778 1.00 21.47 ? 410 THR A N 1 ATOM 2940 C CA . THR A 1 384 ? -36.115 -13.375 -13.632 1.00 20.98 ? 410 THR A CA 1 ATOM 2941 C C . THR A 1 384 ? -35.163 -13.709 -12.487 1.00 20.09 ? 410 THR A C 1 ATOM 2942 O O . THR A 1 384 ? -35.591 -13.942 -11.362 1.00 19.69 ? 410 THR A O 1 ATOM 2943 C CB . THR A 1 384 ? -36.754 -11.996 -13.374 1.00 21.22 ? 410 THR A CB 1 ATOM 2944 O OG1 . THR A 1 384 ? -37.787 -11.763 -14.332 1.00 22.12 ? 410 THR A OG1 1 ATOM 2945 C CG2 . THR A 1 384 ? -35.717 -10.882 -13.502 1.00 21.19 ? 410 THR A CG2 1 ATOM 2946 N N . VAL A 1 385 ? -33.870 -13.724 -12.791 1.00 19.58 ? 411 VAL A N 1 ATOM 2947 C CA . VAL A 1 385 ? -32.835 -13.974 -11.799 1.00 19.37 ? 411 VAL A CA 1 ATOM 2948 C C . VAL A 1 385 ? -32.717 -12.746 -10.896 1.00 19.27 ? 411 VAL A C 1 ATOM 2949 O O . VAL A 1 385 ? -32.609 -11.624 -11.382 1.00 19.38 ? 411 VAL A O 1 ATOM 2950 C CB . VAL A 1 385 ? -31.478 -14.283 -12.473 1.00 19.41 ? 411 VAL A CB 1 ATOM 2951 C CG1 . VAL A 1 385 ? -30.364 -14.406 -11.439 1.00 19.38 ? 411 VAL A CG1 1 ATOM 2952 C CG2 . VAL A 1 385 ? -31.583 -15.560 -13.300 1.00 19.44 ? 411 VAL A CG2 1 ATOM 2953 N N . LEU A 1 386 ? -32.763 -12.970 -9.584 1.00 19.14 ? 412 LEU A N 1 ATOM 2954 C CA . LEU A 1 386 ? -32.622 -11.904 -8.595 1.00 19.05 ? 412 LEU A CA 1 ATOM 2955 C C . LEU A 1 386 ? -31.318 -12.085 -7.824 1.00 18.87 ? 412 LEU A C 1 ATOM 2956 O O . LEU A 1 386 ? -31.099 -13.126 -7.208 1.00 19.38 ? 412 LEU A O 1 ATOM 2957 C CB . LEU A 1 386 ? -33.795 -11.939 -7.613 1.00 19.04 ? 412 LEU A CB 1 ATOM 2958 C CG . LEU A 1 386 ? -35.205 -11.901 -8.204 1.00 19.09 ? 412 LEU A CG 1 ATOM 2959 C CD1 . LEU A 1 386 ? -36.241 -12.092 -7.107 1.00 19.10 ? 412 LEU A CD1 1 ATOM 2960 C CD2 . LEU A 1 386 ? -35.451 -10.600 -8.951 1.00 19.01 ? 412 LEU A CD2 1 ATOM 2961 N N . ASP A 1 387 ? -30.452 -11.077 -7.852 1.00 18.56 ? 413 ASP A N 1 ATOM 2962 C CA . ASP A 1 387 ? -29.237 -11.110 -7.040 1.00 18.44 ? 413 ASP A CA 1 ATOM 2963 C C . ASP A 1 387 ? -29.582 -10.727 -5.593 1.00 18.07 ? 413 ASP A C 1 ATOM 2964 O O . ASP A 1 387 ? -30.751 -10.486 -5.270 1.00 17.51 ? 413 ASP A O 1 ATOM 2965 C CB . ASP A 1 387 ? -28.140 -10.216 -7.639 1.00 18.34 ? 413 ASP A CB 1 ATOM 2966 C CG . ASP A 1 387 ? -28.461 -8.733 -7.549 1.00 18.33 ? 413 ASP A CG 1 ATOM 2967 O OD1 . ASP A 1 387 ? -29.434 -8.353 -6.872 1.00 18.53 ? 413 ASP A OD1 1 ATOM 2968 O OD2 . ASP A 1 387 ? -27.729 -7.940 -8.167 1.00 18.60 ? 413 ASP A OD2 1 ATOM 2969 N N . SER A 1 388 ? -28.575 -10.664 -4.726 1.00 17.93 ? 414 SER A N 1 ATOM 2970 C CA . SER A 1 388 ? -28.817 -10.399 -3.303 1.00 18.04 ? 414 SER A CA 1 ATOM 2971 C C . SER A 1 388 ? -29.346 -8.983 -2.993 1.00 18.17 ? 414 SER A C 1 ATOM 2972 O O . SER A 1 388 ? -29.763 -8.712 -1.871 1.00 18.30 ? 414 SER A O 1 ATOM 2973 C CB . SER A 1 388 ? -27.559 -10.699 -2.491 1.00 17.98 ? 414 SER A CB 1 ATOM 2974 O OG . SER A 1 388 ? -27.225 -12.072 -2.587 1.00 17.71 ? 414 SER A OG 1 ATOM 2975 N N . ASN A 1 389 ? -29.353 -8.097 -3.985 1.00 18.64 ? 415 ASN A N 1 ATOM 2976 C CA . ASN A 1 389 ? -29.985 -6.779 -3.873 1.00 19.09 ? 415 ASN A CA 1 ATOM 2977 C C . ASN A 1 389 ? -31.521 -6.888 -3.981 1.00 19.03 ? 415 ASN A C 1 ATOM 2978 O O . ASN A 1 389 ? -32.163 -6.130 -4.707 1.00 19.02 ? 415 ASN A O 1 ATOM 2979 C CB . ASN A 1 389 ? -29.410 -5.876 -4.970 1.00 19.83 ? 415 ASN A CB 1 ATOM 2980 C CG . ASN A 1 389 ? -29.801 -4.407 -4.834 1.00 20.74 ? 415 ASN A CG 1 ATOM 2981 O OD1 . ASN A 1 389 ? -30.340 -3.961 -3.819 1.00 20.30 ? 415 ASN A OD1 1 ATOM 2982 N ND2 . ASN A 1 389 ? -29.508 -3.640 -5.896 1.00 21.89 ? 415 ASN A ND2 1 ATOM 2983 N N . HIS A 1 390 ? -32.099 -7.839 -3.246 1.00 18.60 ? 416 HIS A N 1 ATOM 2984 C CA . HIS A 1 390 ? -33.532 -8.140 -3.299 1.00 18.39 ? 416 HIS A CA 1 ATOM 2985 C C . HIS A 1 390 ? -33.957 -8.753 -1.971 1.00 17.74 ? 416 HIS A C 1 ATOM 2986 O O . HIS A 1 390 ? -33.113 -9.151 -1.169 1.00 17.52 ? 416 HIS A O 1 ATOM 2987 C CB . HIS A 1 390 ? -33.856 -9.108 -4.445 1.00 18.52 ? 416 HIS A CB 1 ATOM 2988 C CG . HIS A 1 390 ? -33.668 -8.513 -5.806 1.00 18.54 ? 416 HIS A CG 1 ATOM 2989 N ND1 . HIS A 1 390 ? -32.498 -8.648 -6.523 1.00 18.52 ? 416 HIS A ND1 1 ATOM 2990 C CD2 . HIS A 1 390 ? -34.494 -7.761 -6.570 1.00 18.41 ? 416 HIS A CD2 1 ATOM 2991 C CE1 . HIS A 1 390 ? -32.614 -8.012 -7.674 1.00 18.51 ? 416 HIS A CE1 1 ATOM 2992 N NE2 . HIS A 1 390 ? -33.816 -7.466 -7.727 1.00 18.64 ? 416 HIS A NE2 1 ATOM 2993 N N . THR A 1 391 ? -35.263 -8.839 -1.750 1.00 17.10 ? 417 THR A N 1 ATOM 2994 C CA . THR A 1 391 ? -35.788 -9.224 -0.439 1.00 16.87 ? 417 THR A CA 1 ATOM 2995 C C . THR A 1 391 ? -35.526 -10.686 -0.085 1.00 16.62 ? 417 THR A C 1 ATOM 2996 O O . THR A 1 391 ? -35.512 -11.040 1.096 1.00 16.75 ? 417 THR A O 1 ATOM 2997 C CB . THR A 1 391 ? -37.299 -8.970 -0.328 1.00 16.62 ? 417 THR A CB 1 ATOM 2998 O OG1 . THR A 1 391 ? -37.970 -9.655 -1.391 1.00 16.88 ? 417 THR A OG1 1 ATOM 2999 C CG2 . THR A 1 391 ? -37.605 -7.480 -0.395 1.00 16.70 ? 417 THR A CG2 1 ATOM 3000 N N . VAL A 1 392 ? -35.335 -11.533 -1.092 1.00 16.19 ? 418 VAL A N 1 ATOM 3001 C CA . VAL A 1 392 ? -35.026 -12.940 -0.856 1.00 16.12 ? 418 VAL A CA 1 ATOM 3002 C C . VAL A 1 392 ? -33.679 -13.270 -1.484 1.00 16.02 ? 418 VAL A C 1 ATOM 3003 O O . VAL A 1 392 ? -33.439 -12.964 -2.655 1.00 16.13 ? 418 VAL A O 1 ATOM 3004 C CB . VAL A 1 392 ? -36.110 -13.879 -1.419 1.00 16.19 ? 418 VAL A CB 1 ATOM 3005 C CG1 . VAL A 1 392 ? -35.803 -15.337 -1.068 1.00 16.24 ? 418 VAL A CG1 1 ATOM 3006 C CG2 . VAL A 1 392 ? -37.481 -13.490 -0.883 1.00 16.08 ? 418 VAL A CG2 1 ATOM 3007 N N . GLY A 1 393 ? -32.799 -13.877 -0.693 1.00 15.59 ? 419 GLY A N 1 ATOM 3008 C CA . GLY A 1 393 ? -31.497 -14.305 -1.185 1.00 15.51 ? 419 GLY A CA 1 ATOM 3009 C C . GLY A 1 393 ? -30.966 -15.501 -0.436 1.00 15.32 ? 419 GLY A C 1 ATOM 3010 O O . GLY A 1 393 ? -31.613 -16.012 0.475 1.00 15.24 ? 419 GLY A O 1 ATOM 3011 N N . VAL A 1 394 ? -29.771 -15.940 -0.812 1.00 15.39 ? 420 VAL A N 1 ATOM 3012 C CA . VAL A 1 394 ? -29.231 -17.188 -0.296 1.00 15.37 ? 420 VAL A CA 1 ATOM 3013 C C . VAL A 1 394 ? -27.707 -17.162 -0.233 1.00 15.26 ? 420 VAL A C 1 ATOM 3014 O O . VAL A 1 394 ? -27.056 -16.526 -1.061 1.00 15.11 ? 420 VAL A O 1 ATOM 3015 C CB . VAL A 1 394 ? -29.738 -18.381 -1.153 1.00 15.35 ? 420 VAL A CB 1 ATOM 3016 C CG1 . VAL A 1 394 ? -29.224 -18.290 -2.582 1.00 15.41 ? 420 VAL A CG1 1 ATOM 3017 C CG2 . VAL A 1 394 ? -29.368 -19.722 -0.529 1.00 15.56 ? 420 VAL A CG2 1 ATOM 3018 N N . LEU A 1 395 ? -27.157 -17.821 0.787 1.00 15.40 ? 421 LEU A N 1 ATOM 3019 C CA . LEU A 1 395 ? -25.746 -18.202 0.815 1.00 15.57 ? 421 LEU A CA 1 ATOM 3020 C C . LEU A 1 395 ? -25.671 -19.705 1.007 1.00 15.65 ? 421 LEU A C 1 ATOM 3021 O O . LEU A 1 395 ? -26.213 -20.238 1.979 1.00 15.71 ? 421 LEU A O 1 ATOM 3022 C CB . LEU A 1 395 ? -24.996 -17.522 1.956 1.00 15.98 ? 421 LEU A CB 1 ATOM 3023 C CG . LEU A 1 395 ? -24.572 -16.067 1.768 1.00 16.19 ? 421 LEU A CG 1 ATOM 3024 C CD1 . LEU A 1 395 ? -23.941 -15.529 3.046 1.00 16.27 ? 421 LEU A CD1 1 ATOM 3025 C CD2 . LEU A 1 395 ? -23.608 -15.935 0.599 1.00 16.12 ? 421 LEU A CD2 1 ATOM 3026 N N . ALA A 1 396 ? -25.005 -20.376 0.073 1.00 15.43 ? 422 ALA A N 1 ATOM 3027 C CA . ALA A 1 396 ? -24.828 -21.817 0.109 1.00 15.44 ? 422 ALA A CA 1 ATOM 3028 C C . ALA A 1 396 ? -23.345 -22.129 0.231 1.00 15.44 ? 422 ALA A C 1 ATOM 3029 O O . ALA A 1 396 ? -22.512 -21.469 -0.391 1.00 15.43 ? 422 ALA A O 1 ATOM 3030 C CB . ALA A 1 396 ? -25.392 -22.446 -1.153 1.00 15.45 ? 422 ALA A CB 1 ATOM 3031 N N . SER A 1 397 ? -23.021 -23.139 1.029 1.00 15.29 ? 423 SER A N 1 ATOM 3032 C CA . SER A 1 397 ? -21.639 -23.522 1.256 1.00 15.34 ? 423 SER A CA 1 ATOM 3033 C C . SER A 1 397 ? -21.504 -25.029 1.440 1.00 15.63 ? 423 SER A C 1 ATOM 3034 O O . SER A 1 397 ? -22.491 -25.721 1.682 1.00 15.31 ? 423 SER A O 1 ATOM 3035 C CB . SER A 1 397 ? -21.085 -22.804 2.488 1.00 15.16 ? 423 SER A CB 1 ATOM 3036 O OG . SER A 1 397 ? -21.719 -23.252 3.676 1.00 15.01 ? 423 SER A OG 1 ATOM 3037 N N . ALA A 1 398 ? -20.270 -25.508 1.320 1.00 16.32 ? 424 ALA A N 1 ATOM 3038 C CA . ALA A 1 398 ? -19.930 -26.919 1.481 1.00 17.19 ? 424 ALA A CA 1 ATOM 3039 C C . ALA A 1 398 ? -18.600 -27.066 2.225 1.00 17.82 ? 424 ALA A C 1 ATOM 3040 O O . ALA A 1 398 ? -17.752 -26.175 2.184 1.00 17.46 ? 424 ALA A O 1 ATOM 3041 C CB . ALA A 1 398 ? -19.846 -27.607 0.121 1.00 17.17 ? 424 ALA A CB 1 ATOM 3042 N N . HIS A 1 399 ? -18.442 -28.202 2.894 1.00 18.94 ? 425 HIS A N 1 ATOM 3043 C CA . HIS A 1 399 ? -17.254 -28.519 3.664 1.00 20.20 ? 425 HIS A CA 1 ATOM 3044 C C . HIS A 1 399 ? -16.594 -29.771 3.107 1.00 21.93 ? 425 HIS A C 1 ATOM 3045 O O . HIS A 1 399 ? -17.240 -30.808 2.961 1.00 20.84 ? 425 HIS A O 1 ATOM 3046 C CB . HIS A 1 399 ? -17.629 -28.777 5.121 1.00 20.09 ? 425 HIS A CB 1 ATOM 3047 C CG . HIS A 1 399 ? -16.479 -29.208 5.972 1.00 20.32 ? 425 HIS A CG 1 ATOM 3048 N ND1 . HIS A 1 399 ? -15.465 -28.349 6.342 1.00 20.65 ? 425 HIS A ND1 1 ATOM 3049 C CD2 . HIS A 1 399 ? -16.184 -30.403 6.533 1.00 20.38 ? 425 HIS A CD2 1 ATOM 3050 C CE1 . HIS A 1 399 ? -14.592 -28.999 7.089 1.00 20.59 ? 425 HIS A CE1 1 ATOM 3051 N NE2 . HIS A 1 399 ? -15.005 -30.247 7.220 1.00 20.64 ? 425 HIS A NE2 1 ATOM 3052 N N . ARG A 1 400 ? -15.306 -29.668 2.810 1.00 24.80 ? 426 ARG A N 1 ATOM 3053 C CA . ARG A 1 400 ? -14.509 -30.828 2.454 1.00 28.02 ? 426 ARG A CA 1 ATOM 3054 C C . ARG A 1 400 ? -13.982 -31.462 3.738 1.00 28.39 ? 426 ARG A C 1 ATOM 3055 O O . ARG A 1 400 ? -13.301 -30.799 4.515 1.00 28.82 ? 426 ARG A O 1 ATOM 3056 C CB . ARG A 1 400 ? -13.352 -30.419 1.555 1.00 30.38 ? 426 ARG A CB 1 ATOM 3057 C CG . ARG A 1 400 ? -12.704 -31.589 0.830 1.00 33.32 ? 426 ARG A CG 1 ATOM 3058 C CD . ARG A 1 400 ? -11.982 -31.127 -0.423 1.00 34.99 ? 426 ARG A CD 1 ATOM 3059 N NE . ARG A 1 400 ? -12.742 -30.087 -1.125 1.00 37.32 ? 426 ARG A NE 1 ATOM 3060 C CZ . ARG A 1 400 ? -13.727 -30.298 -2.002 1.00 37.02 ? 426 ARG A CZ 1 ATOM 3061 N NH1 . ARG A 1 400 ? -14.107 -31.530 -2.333 1.00 36.91 ? 426 ARG A NH1 1 ATOM 3062 N NH2 . ARG A 1 400 ? -14.333 -29.254 -2.559 1.00 36.34 ? 426 ARG A NH2 1 ATOM 3063 N N . PRO A 1 401 ? -14.304 -32.744 3.973 1.00 29.37 ? 427 PRO A N 1 ATOM 3064 C CA . PRO A 1 401 ? -13.894 -33.367 5.229 1.00 30.44 ? 427 PRO A CA 1 ATOM 3065 C C . PRO A 1 401 ? -12.401 -33.675 5.300 1.00 32.31 ? 427 PRO A C 1 ATOM 3066 O O . PRO A 1 401 ? -11.737 -33.764 4.267 1.00 31.87 ? 427 PRO A O 1 ATOM 3067 C CB . PRO A 1 401 ? -14.704 -34.660 5.252 1.00 30.02 ? 427 PRO A CB 1 ATOM 3068 C CG . PRO A 1 401 ? -14.944 -34.986 3.822 1.00 29.32 ? 427 PRO A CG 1 ATOM 3069 C CD . PRO A 1 401 ? -15.063 -33.671 3.113 1.00 28.87 ? 427 PRO A CD 1 ATOM 3070 N N . GLN A 1 402 ? -11.896 -33.835 6.521 1.00 34.98 ? 428 GLN A N 1 ATOM 3071 C CA . GLN A 1 402 ? -10.492 -34.177 6.758 1.00 37.95 ? 428 GLN A CA 1 ATOM 3072 C C . GLN A 1 402 ? -10.352 -35.568 7.415 1.00 37.75 ? 428 GLN A C 1 ATOM 3073 O O . GLN A 1 402 ? -10.086 -36.551 6.722 1.00 38.63 ? 428 GLN A O 1 ATOM 3074 C CB . GLN A 1 402 ? -9.784 -33.067 7.563 1.00 40.76 ? 428 GLN A CB 1 ATOM 3075 C CG . GLN A 1 402 ? -10.392 -32.738 8.931 1.00 43.39 ? 428 GLN A CG 1 ATOM 3076 C CD . GLN A 1 402 ? -10.393 -31.254 9.262 1.00 45.70 ? 428 GLN A CD 1 ATOM 3077 O OE1 . GLN A 1 402 ? -9.717 -30.815 10.196 1.00 48.66 ? 428 GLN A OE1 1 ATOM 3078 N NE2 . GLN A 1 402 ? -11.163 -30.474 8.504 1.00 46.28 ? 428 GLN A NE2 1 ATOM 3079 N N . GLY A 1 403 ? -10.573 -35.667 8.723 1.00 36.58 ? 429 GLY A N 1 ATOM 3080 C CA . GLY A 1 403 ? -10.234 -36.880 9.466 1.00 35.72 ? 429 GLY A CA 1 ATOM 3081 C C . GLY A 1 403 ? -11.394 -37.847 9.616 1.00 34.09 ? 429 GLY A C 1 ATOM 3082 O O . GLY A 1 403 ? -12.436 -37.676 8.978 1.00 32.93 ? 429 GLY A O 1 ATOM 3083 N N . PRO A 1 404 ? -11.218 -38.877 10.464 1.00 32.43 ? 430 PRO A N 1 ATOM 3084 C CA . PRO A 1 404 ? -12.301 -39.814 10.796 1.00 31.37 ? 430 PRO A CA 1 ATOM 3085 C C . PRO A 1 404 ? -13.401 -39.207 11.682 1.00 29.94 ? 430 PRO A C 1 ATOM 3086 O O . PRO A 1 404 ? -14.468 -39.809 11.835 1.00 29.28 ? 430 PRO A O 1 ATOM 3087 C CB . PRO A 1 404 ? -11.573 -40.946 11.536 1.00 31.85 ? 430 PRO A CB 1 ATOM 3088 C CG . PRO A 1 404 ? -10.343 -40.308 12.088 1.00 31.98 ? 430 PRO A CG 1 ATOM 3089 C CD . PRO A 1 404 ? -9.937 -39.276 11.078 1.00 32.12 ? 430 PRO A CD 1 ATOM 3090 N N . ALA A 1 405 ? -13.136 -38.036 12.264 1.00 28.66 ? 431 ALA A N 1 ATOM 3091 C CA . ALA A 1 405 ? -14.131 -37.293 13.044 1.00 27.54 ? 431 ALA A CA 1 ATOM 3092 C C . ALA A 1 405 ? -14.793 -36.184 12.212 1.00 26.58 ? 431 ALA A C 1 ATOM 3093 O O . ALA A 1 405 ? -15.355 -35.238 12.763 1.00 25.62 ? 431 ALA A O 1 ATOM 3094 C CB . ALA A 1 405 ? -13.477 -36.699 14.285 1.00 27.80 ? 431 ALA A CB 1 ATOM 3095 N N . ASP A 1 406 ? -14.737 -36.316 10.888 1.00 25.51 ? 432 ASP A N 1 ATOM 3096 C CA . ASP A 1 406 ? -15.268 -35.305 9.981 1.00 24.18 ? 432 ASP A CA 1 ATOM 3097 C C . ASP A 1 406 ? -15.946 -35.966 8.783 1.00 22.64 ? 432 ASP A C 1 ATOM 3098 O O . ASP A 1 406 ? -15.675 -37.128 8.473 1.00 22.28 ? 432 ASP A O 1 ATOM 3099 C CB . ASP A 1 406 ? -14.123 -34.407 9.503 1.00 24.51 ? 432 ASP A CB 1 ATOM 3100 C CG . ASP A 1 406 ? -14.602 -33.071 8.982 1.00 24.80 ? 432 ASP A CG 1 ATOM 3101 O OD1 . ASP A 1 406 ? -15.817 -32.782 9.058 1.00 25.00 ? 432 ASP A OD1 1 ATOM 3102 O OD2 . ASP A 1 406 ? -13.757 -32.298 8.486 1.00 25.70 ? 432 ASP A OD2 1 ATOM 3103 N N . ALA A 1 407 ? -16.832 -35.221 8.124 1.00 20.85 ? 433 ALA A N 1 ATOM 3104 C CA . ALA A 1 407 ? -17.508 -35.690 6.913 1.00 19.58 ? 433 ALA A CA 1 ATOM 3105 C C . ALA A 1 407 ? -18.070 -34.518 6.100 1.00 18.56 ? 433 ALA A C 1 ATOM 3106 O O . ALA A 1 407 ? -18.104 -33.375 6.569 1.00 18.24 ? 433 ALA A O 1 ATOM 3107 C CB . ALA A 1 407 ? -18.608 -36.682 7.260 1.00 19.62 ? 433 ALA A CB 1 ATOM 3108 N N . TRP A 1 408 ? -18.491 -34.812 4.873 1.00 17.14 ? 434 TRP A N 1 ATOM 3109 C CA . TRP A 1 408 ? -19.036 -33.802 3.970 1.00 16.45 ? 434 TRP A CA 1 ATOM 3110 C C . TRP A 1 408 ? -20.228 -33.089 4.615 1.00 15.88 ? 434 TRP A C 1 ATOM 3111 O O . TRP A 1 408 ? -21.043 -33.717 5.301 1.00 15.81 ? 434 TRP A O 1 ATOM 3112 C CB . TRP A 1 408 ? -19.459 -34.448 2.641 1.00 16.28 ? 434 TRP A CB 1 ATOM 3113 C CG . TRP A 1 408 ? -19.948 -33.467 1.623 1.00 16.03 ? 434 TRP A CG 1 ATOM 3114 C CD1 . TRP A 1 408 ? -19.204 -32.831 0.678 1.00 16.10 ? 434 TRP A CD1 1 ATOM 3115 C CD2 . TRP A 1 408 ? -21.291 -33.002 1.458 1.00 15.79 ? 434 TRP A CD2 1 ATOM 3116 N NE1 . TRP A 1 408 ? -19.998 -31.996 -0.064 1.00 16.30 ? 434 TRP A NE1 1 ATOM 3117 C CE2 . TRP A 1 408 ? -21.286 -32.085 0.393 1.00 15.93 ? 434 TRP A CE2 1 ATOM 3118 C CE3 . TRP A 1 408 ? -22.497 -33.270 2.114 1.00 15.65 ? 434 TRP A CE3 1 ATOM 3119 C CZ2 . TRP A 1 408 ? -22.440 -31.437 -0.040 1.00 15.86 ? 434 TRP A CZ2 1 ATOM 3120 C CZ3 . TRP A 1 408 ? -23.642 -32.626 1.686 1.00 15.69 ? 434 TRP A CZ3 1 ATOM 3121 C CH2 . TRP A 1 408 ? -23.608 -31.721 0.620 1.00 15.79 ? 434 TRP A CH2 1 ATOM 3122 N N . ARG A 1 409 ? -20.298 -31.778 4.412 1.00 15.21 ? 435 ARG A N 1 ATOM 3123 C CA . ARG A 1 409 ? -21.425 -30.967 4.871 1.00 15.21 ? 435 ARG A CA 1 ATOM 3124 C C . ARG A 1 409 ? -21.784 -29.925 3.832 1.00 14.83 ? 435 ARG A C 1 ATOM 3125 O O . ARG A 1 409 ? -20.930 -29.480 3.068 1.00 14.89 ? 435 ARG A O 1 ATOM 3126 C CB . ARG A 1 409 ? -21.093 -30.209 6.155 1.00 15.25 ? 435 ARG A CB 1 ATOM 3127 C CG . ARG A 1 409 ? -20.535 -31.040 7.286 1.00 15.44 ? 435 ARG A CG 1 ATOM 3128 C CD . ARG A 1 409 ? -20.549 -30.237 8.572 1.00 15.47 ? 435 ARG A CD 1 ATOM 3129 N NE . ARG A 1 409 ? -19.631 -29.097 8.537 1.00 15.21 ? 435 ARG A NE 1 ATOM 3130 C CZ . ARG A 1 409 ? -18.442 -29.054 9.141 1.00 15.16 ? 435 ARG A CZ 1 ATOM 3131 N NH1 . ARG A 1 409 ? -17.984 -30.094 9.838 1.00 15.07 ? 435 ARG A NH1 1 ATOM 3132 N NH2 . ARG A 1 409 ? -17.694 -27.961 9.043 1.00 14.87 ? 435 ARG A NH2 1 ATOM 3133 N N . ALA A 1 410 ? -23.046 -29.522 3.824 1.00 14.35 ? 436 ALA A N 1 ATOM 3134 C CA . ALA A 1 410 ? -23.450 -28.328 3.114 1.00 14.06 ? 436 ALA A CA 1 ATOM 3135 C C . ALA A 1 410 ? -24.354 -27.523 4.023 1.00 13.89 ? 436 ALA A C 1 ATOM 3136 O O . ALA A 1 410 ? -25.135 -28.091 4.789 1.00 13.87 ? 436 ALA A O 1 ATOM 3137 C CB . ALA A 1 410 ? -24.164 -28.681 1.824 1.00 14.20 ? 436 ALA A CB 1 ATOM 3138 N N . ALA A 1 411 ? -24.225 -26.202 3.954 1.00 13.75 ? 437 ALA A N 1 ATOM 3139 C CA . ALA A 1 411 ? -25.100 -25.304 4.691 1.00 13.57 ? 437 ALA A CA 1 ATOM 3140 C C . ALA A 1 411 ? -25.681 -24.288 3.730 1.00 13.51 ? 437 ALA A C 1 ATOM 3141 O O . ALA A 1 411 ? -24.945 -23.618 3.001 1.00 13.40 ? 437 ALA A O 1 ATOM 3142 C CB . ALA A 1 411 ? -24.339 -24.611 5.806 1.00 13.59 ? 437 ALA A CB 1 ATOM 3143 N N . VAL A 1 412 ? -27.006 -24.193 3.724 1.00 13.48 ? 438 VAL A N 1 ATOM 3144 C CA . VAL A 1 412 ? -27.709 -23.242 2.879 1.00 13.35 ? 438 VAL A CA 1 ATOM 3145 C C . VAL A 1 412 ? -28.519 -22.322 3.770 1.00 13.09 ? 438 VAL A C 1 ATOM 3146 O O . VAL A 1 412 ? -29.378 -22.779 4.524 1.00 12.94 ? 438 VAL A O 1 ATOM 3147 C CB . VAL A 1 412 ? -28.637 -23.949 1.882 1.00 13.45 ? 438 VAL A CB 1 ATOM 3148 C CG1 . VAL A 1 412 ? -29.417 -22.937 1.054 1.00 13.60 ? 438 VAL A CG1 1 ATOM 3149 C CG2 . VAL A 1 412 ? -27.822 -24.850 0.970 1.00 13.65 ? 438 VAL A CG2 1 ATOM 3150 N N . LEU A 1 413 ? -28.238 -21.025 3.670 1.00 12.71 ? 439 LEU A N 1 ATOM 3151 C CA . LEU A 1 413 ? -28.913 -20.020 4.476 1.00 12.37 ? 439 LEU A CA 1 ATOM 3152 C C . LEU A 1 413 ? -29.716 -19.107 3.565 1.00 12.13 ? 439 LEU A C 1 ATOM 3153 O O . LEU A 1 413 ? -29.155 -18.389 2.741 1.00 11.95 ? 439 LEU A O 1 ATOM 3154 C CB . LEU A 1 413 ? -27.890 -19.217 5.283 1.00 12.36 ? 439 LEU A CB 1 ATOM 3155 C CG . LEU A 1 413 ? -28.426 -18.122 6.212 1.00 12.38 ? 439 LEU A CG 1 ATOM 3156 C CD1 . LEU A 1 413 ? -29.422 -18.692 7.214 1.00 12.43 ? 439 LEU A CD1 1 ATOM 3157 C CD2 . LEU A 1 413 ? -27.275 -17.427 6.927 1.00 12.39 ? 439 LEU A CD2 1 ATOM 3158 N N . ILE A 1 414 ? -31.034 -19.149 3.716 1.00 12.09 ? 440 ILE A N 1 ATOM 3159 C CA . ILE A 1 414 ? -31.942 -18.324 2.923 1.00 12.05 ? 440 ILE A CA 1 ATOM 3160 C C . ILE A 1 414 ? -32.499 -17.232 3.815 1.00 11.95 ? 440 ILE A C 1 ATOM 3161 O O . ILE A 1 414 ? -32.955 -17.508 4.919 1.00 12.08 ? 440 ILE A O 1 ATOM 3162 C CB . ILE A 1 414 ? -33.110 -19.157 2.357 1.00 12.07 ? 440 ILE A CB 1 ATOM 3163 C CG1 . ILE A 1 414 ? -32.574 -20.248 1.426 1.00 12.17 ? 440 ILE A CG1 1 ATOM 3164 C CG2 . ILE A 1 414 ? -34.105 -18.263 1.618 1.00 12.08 ? 440 ILE A CG2 1 ATOM 3165 C CD1 . ILE A 1 414 ? -33.606 -21.274 0.999 1.00 12.14 ? 440 ILE A CD1 1 ATOM 3166 N N . TYR A 1 415 ? -32.455 -15.992 3.340 1.00 12.03 ? 441 TYR A N 1 ATOM 3167 C CA . TYR A 1 415 ? -33.053 -14.877 4.069 1.00 12.04 ? 441 TYR A CA 1 ATOM 3168 C C . TYR A 1 415 ? -34.261 -14.327 3.314 1.00 12.04 ? 441 TYR A C 1 ATOM 3169 O O . TYR A 1 415 ? -34.303 -14.341 2.081 1.00 11.89 ? 441 TYR A O 1 ATOM 3170 C CB . TYR A 1 415 ? -32.031 -13.763 4.324 1.00 12.07 ? 441 TYR A CB 1 ATOM 3171 C CG . TYR A 1 415 ? -31.535 -13.051 3.077 1.00 12.31 ? 441 TYR A CG 1 ATOM 3172 C CD1 . TYR A 1 415 ? -32.243 -11.989 2.524 1.00 12.36 ? 441 TYR A CD1 1 ATOM 3173 C CD2 . TYR A 1 415 ? -30.354 -13.441 2.457 1.00 12.49 ? 441 TYR A CD2 1 ATOM 3174 C CE1 . TYR A 1 415 ? -31.792 -11.342 1.385 1.00 12.55 ? 441 TYR A CE1 1 ATOM 3175 C CE2 . TYR A 1 415 ? -29.892 -12.796 1.321 1.00 12.55 ? 441 TYR A CE2 1 ATOM 3176 C CZ . TYR A 1 415 ? -30.609 -11.746 0.792 1.00 12.47 ? 441 TYR A CZ 1 ATOM 3177 O OH . TYR A 1 415 ? -30.150 -11.121 -0.340 1.00 12.29 ? 441 TYR A OH 1 ATOM 3178 N N . ALA A 1 416 ? -35.251 -13.874 4.070 1.00 12.06 ? 442 ALA A N 1 ATOM 3179 C CA . ALA A 1 416 ? -36.305 -13.024 3.536 1.00 12.11 ? 442 ALA A CA 1 ATOM 3180 C C . ALA A 1 416 ? -36.258 -11.759 4.373 1.00 12.07 ? 442 ALA A C 1 ATOM 3181 O O . ALA A 1 416 ? -36.540 -11.793 5.568 1.00 11.87 ? 442 ALA A O 1 ATOM 3182 C CB . ALA A 1 416 ? -37.661 -13.703 3.632 1.00 12.08 ? 442 ALA A CB 1 ATOM 3183 N N . SER A 1 417 ? -35.861 -10.653 3.752 1.00 12.11 ? 443 SER A N 1 ATOM 3184 C CA . SER A 1 417 ? -35.638 -9.407 4.476 1.00 12.04 ? 443 SER A CA 1 ATOM 3185 C C . SER A 1 417 ? -35.910 -8.194 3.606 1.00 12.16 ? 443 SER A C 1 ATOM 3186 O O . SER A 1 417 ? -35.340 -8.058 2.517 1.00 12.00 ? 443 SER A O 1 ATOM 3187 C CB . SER A 1 417 ? -34.195 -9.346 4.977 1.00 12.08 ? 443 SER A CB 1 ATOM 3188 O OG . SER A 1 417 ? -33.870 -8.050 5.458 1.00 11.97 ? 443 SER A OG 1 ATOM 3189 N N . ASP A 1 418 ? -36.773 -7.308 4.098 1.00 12.31 ? 444 ASP A N 1 ATOM 3190 C CA . ASP A 1 418 ? -36.993 -6.020 3.457 1.00 12.47 ? 444 ASP A CA 1 ATOM 3191 C C . ASP A 1 418 ? -36.289 -4.940 4.276 1.00 12.58 ? 444 ASP A C 1 ATOM 3192 O O . ASP A 1 418 ? -36.874 -3.914 4.618 1.00 12.56 ? 444 ASP A O 1 ATOM 3193 C CB . ASP A 1 418 ? -38.490 -5.720 3.311 1.00 12.48 ? 444 ASP A CB 1 ATOM 3194 C CG . ASP A 1 418 ? -38.755 -4.487 2.465 1.00 12.40 ? 444 ASP A CG 1 ATOM 3195 O OD1 . ASP A 1 418 ? -37.892 -4.148 1.631 1.00 12.40 ? 444 ASP A OD1 1 ATOM 3196 O OD2 . ASP A 1 418 ? -39.814 -3.852 2.642 1.00 12.16 ? 444 ASP A OD2 1 ATOM 3197 N N . ASP A 1 419 ? -35.021 -5.195 4.584 1.00 12.92 ? 445 ASP A N 1 ATOM 3198 C CA . ASP A 1 419 ? -34.205 -4.298 5.391 1.00 13.14 ? 445 ASP A CA 1 ATOM 3199 C C . ASP A 1 419 ? -34.883 -4.014 6.738 1.00 13.58 ? 445 ASP A C 1 ATOM 3200 O O . ASP A 1 419 ? -35.119 -4.959 7.495 1.00 13.73 ? 445 ASP A O 1 ATOM 3201 C CB . ASP A 1 419 ? -33.849 -3.041 4.590 1.00 12.94 ? 445 ASP A CB 1 ATOM 3202 C CG . ASP A 1 419 ? -32.909 -3.341 3.414 1.00 12.83 ? 445 ASP A CG 1 ATOM 3203 O OD1 . ASP A 1 419 ? -32.491 -4.514 3.240 1.00 12.65 ? 445 ASP A OD1 1 ATOM 3204 O OD2 . ASP A 1 419 ? -32.572 -2.397 2.671 1.00 12.34 ? 445 ASP A OD2 1 ATOM 3205 N N . THR A 1 420 ? -35.218 -2.760 7.047 1.00 13.99 ? 446 THR A N 1 ATOM 3206 C CA . THR A 1 420 ? -35.763 -2.437 8.377 1.00 14.44 ? 446 THR A CA 1 ATOM 3207 C C . THR A 1 420 ? -37.278 -2.603 8.488 1.00 15.19 ? 446 THR A C 1 ATOM 3208 O O . THR A 1 420 ? -37.827 -2.484 9.581 1.00 15.57 ? 446 THR A O 1 ATOM 3209 C CB . THR A 1 420 ? -35.399 -1.009 8.824 1.00 14.16 ? 446 THR A CB 1 ATOM 3210 O OG1 . THR A 1 420 ? -35.988 -0.058 7.933 1.00 13.86 ? 446 THR A OG1 1 ATOM 3211 C CG2 . THR A 1 420 ? -33.878 -0.828 8.855 1.00 14.29 ? 446 THR A CG2 1 ATOM 3212 N N . ARG A 1 421 ? -37.944 -2.882 7.373 1.00 16.12 ? 447 ARG A N 1 ATOM 3213 C CA . ARG A 1 421 ? -39.397 -3.032 7.355 1.00 17.02 ? 447 ARG A CA 1 ATOM 3214 C C . ARG A 1 421 ? -39.809 -4.491 7.551 1.00 17.03 ? 447 ARG A C 1 ATOM 3215 O O . ARG A 1 421 ? -39.462 -5.359 6.746 1.00 16.84 ? 447 ARG A O 1 ATOM 3216 C CB . ARG A 1 421 ? -39.973 -2.506 6.036 1.00 17.84 ? 447 ARG A CB 1 ATOM 3217 C CG . ARG A 1 421 ? -39.914 -0.985 5.895 1.00 18.78 ? 447 ARG A CG 1 ATOM 3218 C CD . ARG A 1 421 ? -40.254 -0.529 4.481 1.00 19.49 ? 447 ARG A CD 1 ATOM 3219 N NE . ARG A 1 421 ? -39.284 -1.036 3.508 1.00 20.45 ? 447 ARG A NE 1 ATOM 3220 C CZ . ARG A 1 421 ? -38.110 -0.471 3.216 1.00 21.51 ? 447 ARG A CZ 1 ATOM 3221 N NH1 . ARG A 1 421 ? -37.723 0.659 3.804 1.00 22.06 ? 447 ARG A NH1 1 ATOM 3222 N NH2 . ARG A 1 421 ? -37.311 -1.040 2.317 1.00 21.96 ? 447 ARG A NH2 1 ATOM 3223 N N . ALA A 1 422 ? -40.542 -4.752 8.628 1.00 17.12 ? 448 ALA A N 1 ATOM 3224 C CA . ALA A 1 422 ? -41.185 -6.045 8.826 1.00 17.41 ? 448 ALA A CA 1 ATOM 3225 C C . ALA A 1 422 ? -42.528 -6.033 8.114 1.00 18.04 ? 448 ALA A C 1 ATOM 3226 O O . ALA A 1 422 ? -43.152 -4.988 7.982 1.00 17.20 ? 448 ALA A O 1 ATOM 3227 C CB . ALA A 1 422 ? -41.378 -6.329 10.305 1.00 17.20 ? 448 ALA A CB 1 ATOM 3228 N N . HIS A 1 423 ? -42.966 -7.202 7.661 1.00 19.24 ? 449 HIS A N 1 ATOM 3229 C CA . HIS A 1 423 ? -44.251 -7.335 6.988 1.00 20.12 ? 449 HIS A CA 1 ATOM 3230 C C . HIS A 1 423 ? -45.002 -8.531 7.554 1.00 21.08 ? 449 HIS A C 1 ATOM 3231 O O . HIS A 1 423 ? -45.098 -9.565 6.901 1.00 20.67 ? 449 HIS A O 1 ATOM 3232 C CB . HIS A 1 423 ? -44.046 -7.510 5.490 1.00 20.31 ? 449 HIS A CB 1 ATOM 3233 C CG . HIS A 1 423 ? -43.398 -6.337 4.822 1.00 20.59 ? 449 HIS A CG 1 ATOM 3234 N ND1 . HIS A 1 423 ? -44.085 -5.182 4.517 1.00 20.94 ? 449 HIS A ND1 1 ATOM 3235 C CD2 . HIS A 1 423 ? -42.126 -6.141 4.401 1.00 20.61 ? 449 HIS A CD2 1 ATOM 3236 C CE1 . HIS A 1 423 ? -43.263 -4.322 3.940 1.00 20.83 ? 449 HIS A CE1 1 ATOM 3237 N NE2 . HIS A 1 423 ? -42.070 -4.880 3.856 1.00 20.73 ? 449 HIS A NE2 1 ATOM 3238 N N . PRO A 1 424 ? -45.544 -8.392 8.776 1.00 22.57 ? 450 PRO A N 1 ATOM 3239 C CA . PRO A 1 424 ? -46.159 -9.534 9.468 1.00 23.43 ? 450 PRO A CA 1 ATOM 3240 C C . PRO A 1 424 ? -47.350 -10.161 8.730 1.00 24.85 ? 450 PRO A C 1 ATOM 3241 O O . PRO A 1 424 ? -47.614 -11.349 8.899 1.00 25.32 ? 450 PRO A O 1 ATOM 3242 C CB . PRO A 1 424 ? -46.590 -8.956 10.825 1.00 23.53 ? 450 PRO A CB 1 ATOM 3243 C CG . PRO A 1 424 ? -46.543 -7.471 10.693 1.00 23.01 ? 450 PRO A CG 1 ATOM 3244 C CD . PRO A 1 424 ? -45.671 -7.127 9.524 1.00 22.90 ? 450 PRO A CD 1 ATOM 3245 N N . ASN A 1 425 ? -48.033 -9.380 7.896 1.00 26.35 ? 451 ASN A N 1 ATOM 3246 C CA . ASN A 1 425 ? -49.223 -9.837 7.185 1.00 27.94 ? 451 ASN A CA 1 ATOM 3247 C C . ASN A 1 425 ? -48.898 -10.364 5.777 1.00 29.15 ? 451 ASN A C 1 ATOM 3248 O O . ASN A 1 425 ? -49.660 -10.149 4.834 1.00 29.96 ? 451 ASN A O 1 ATOM 3249 C CB . ASN A 1 425 ? -50.220 -8.663 7.115 1.00 28.30 ? 451 ASN A CB 1 ATOM 3250 C CG . ASN A 1 425 ? -51.615 -9.078 6.678 1.00 28.85 ? 451 ASN A CG 1 ATOM 3251 O OD1 . ASN A 1 425 ? -52.206 -8.453 5.787 1.00 28.88 ? 451 ASN A OD1 1 ATOM 3252 N ND2 . ASN A 1 425 ? -52.163 -10.114 7.310 1.00 29.06 ? 451 ASN A ND2 1 ATOM 3253 N N . ARG A 1 426 ? -47.769 -11.056 5.633 1.00 29.85 ? 452 ARG A N 1 ATOM 3254 C CA . ARG A 1 426 ? -47.319 -11.553 4.328 1.00 29.75 ? 452 ARG A CA 1 ATOM 3255 C C . ARG A 1 426 ? -46.665 -12.913 4.463 1.00 28.62 ? 452 ARG A C 1 ATOM 3256 O O . ARG A 1 426 ? -45.989 -13.182 5.452 1.00 28.38 ? 452 ARG A O 1 ATOM 3257 C CB . ARG A 1 426 ? -46.302 -10.596 3.699 1.00 30.88 ? 452 ARG A CB 1 ATOM 3258 C CG . ARG A 1 426 ? -46.886 -9.257 3.298 1.00 32.59 ? 452 ARG A CG 1 ATOM 3259 C CD . ARG A 1 426 ? -45.880 -8.321 2.639 1.00 34.14 ? 452 ARG A CD 1 ATOM 3260 N NE . ARG A 1 426 ? -45.192 -8.898 1.486 1.00 35.70 ? 452 ARG A NE 1 ATOM 3261 C CZ . ARG A 1 426 ? -44.326 -8.229 0.724 1.00 36.44 ? 452 ARG A CZ 1 ATOM 3262 N NH1 . ARG A 1 426 ? -44.052 -6.950 0.977 1.00 36.60 ? 452 ARG A NH1 1 ATOM 3263 N NH2 . ARG A 1 426 ? -43.738 -8.839 -0.304 1.00 36.16 ? 452 ARG A NH2 1 ATOM 3264 N N . SER A 1 427 ? -46.870 -13.762 3.463 1.00 27.56 ? 453 SER A N 1 ATOM 3265 C CA . SER A 1 427 ? -46.114 -15.001 3.330 1.00 27.47 ? 453 SER A CA 1 ATOM 3266 C C . SER A 1 427 ? -45.286 -14.930 2.055 1.00 26.06 ? 453 SER A C 1 ATOM 3267 O O . SER A 1 427 ? -45.659 -14.247 1.102 1.00 26.64 ? 453 SER A O 1 ATOM 3268 C CB . SER A 1 427 ? -47.048 -16.212 3.296 1.00 28.36 ? 453 SER A CB 1 ATOM 3269 O OG . SER A 1 427 ? -48.120 -16.008 2.395 1.00 29.99 ? 453 SER A OG 1 ATOM 3270 N N . VAL A 1 428 ? -44.152 -15.618 2.054 1.00 24.41 ? 454 VAL A N 1 ATOM 3271 C CA . VAL A 1 428 ? -43.284 -15.688 0.887 1.00 23.09 ? 454 VAL A CA 1 ATOM 3272 C C . VAL A 1 428 ? -43.118 -17.163 0.529 1.00 22.09 ? 454 VAL A C 1 ATOM 3273 O O . VAL A 1 428 ? -42.396 -17.908 1.207 1.00 21.13 ? 454 VAL A O 1 ATOM 3274 C CB . VAL A 1 428 ? -41.910 -15.030 1.155 1.00 23.49 ? 454 VAL A CB 1 ATOM 3275 C CG1 . VAL A 1 428 ? -41.061 -15.029 -0.107 1.00 24.01 ? 454 VAL A CG1 1 ATOM 3276 C CG2 . VAL A 1 428 ? -42.083 -13.605 1.664 1.00 23.27 ? 454 VAL A CG2 1 ATOM 3277 N N . ALA A 1 429 ? -43.815 -17.588 -0.521 1.00 21.03 ? 455 ALA A N 1 ATOM 3278 C CA . ALA A 1 429 ? -43.722 -18.966 -0.979 1.00 20.59 ? 455 ALA A CA 1 ATOM 3279 C C . ALA A 1 429 ? -42.377 -19.154 -1.664 1.00 20.03 ? 455 ALA A C 1 ATOM 3280 O O . ALA A 1 429 ? -42.053 -18.440 -2.610 1.00 20.41 ? 455 ALA A O 1 ATOM 3281 C CB . ALA A 1 429 ? -44.862 -19.299 -1.925 1.00 20.50 ? 455 ALA A CB 1 ATOM 3282 N N . VAL A 1 430 ? -41.591 -20.100 -1.165 1.00 19.38 ? 456 VAL A N 1 ATOM 3283 C CA . VAL A 1 430 ? -40.277 -20.396 -1.729 1.00 19.06 ? 456 VAL A CA 1 ATOM 3284 C C . VAL A 1 430 ? -40.220 -21.856 -2.156 1.00 18.30 ? 456 VAL A C 1 ATOM 3285 O O . VAL A 1 430 ? -40.817 -22.717 -1.516 1.00 17.82 ? 456 VAL A O 1 ATOM 3286 C CB . VAL A 1 430 ? -39.161 -20.098 -0.704 1.00 19.22 ? 456 VAL A CB 1 ATOM 3287 C CG1 . VAL A 1 430 ? -37.799 -20.546 -1.215 1.00 19.41 ? 456 VAL A CG1 1 ATOM 3288 C CG2 . VAL A 1 430 ? -39.141 -18.612 -0.385 1.00 19.53 ? 456 VAL A CG2 1 ATOM 3289 N N . THR A 1 431 ? -39.514 -22.125 -3.249 1.00 17.97 ? 457 THR A N 1 ATOM 3290 C CA . THR A 1 431 ? -39.183 -23.496 -3.623 1.00 17.53 ? 457 THR A CA 1 ATOM 3291 C C . THR A 1 431 ? -37.669 -23.617 -3.633 1.00 17.28 ? 457 THR A C 1 ATOM 3292 O O . THR A 1 431 ? -36.992 -22.924 -4.383 1.00 17.20 ? 457 THR A O 1 ATOM 3293 C CB . THR A 1 431 ? -39.774 -23.882 -4.993 1.00 17.30 ? 457 THR A CB 1 ATOM 3294 O OG1 . THR A 1 431 ? -41.194 -23.722 -4.960 1.00 17.10 ? 457 THR A OG1 1 ATOM 3295 C CG2 . THR A 1 431 ? -39.451 -25.332 -5.346 1.00 17.17 ? 457 THR A CG2 1 ATOM 3296 N N . LEU A 1 432 ? -37.151 -24.485 -2.773 1.00 17.42 ? 458 LEU A N 1 ATOM 3297 C CA . LEU A 1 432 ? -35.731 -24.778 -2.718 1.00 17.53 ? 458 LEU A CA 1 ATOM 3298 C C . LEU A 1 432 ? -35.481 -26.056 -3.489 1.00 17.77 ? 458 LEU A C 1 ATOM 3299 O O . LEU A 1 432 ? -36.052 -27.098 -3.157 1.00 18.16 ? 458 LEU A O 1 ATOM 3300 C CB . LEU A 1 432 ? -35.270 -24.966 -1.269 1.00 17.75 ? 458 LEU A CB 1 ATOM 3301 C CG . LEU A 1 432 ? -33.884 -25.585 -1.032 1.00 17.83 ? 458 LEU A CG 1 ATOM 3302 C CD1 . LEU A 1 432 ? -32.777 -24.790 -1.706 1.00 18.01 ? 458 LEU A CD1 1 ATOM 3303 C CD2 . LEU A 1 432 ? -33.613 -25.695 0.457 1.00 17.86 ? 458 LEU A CD2 1 ATOM 3304 N N A ARG A 1 433 ? -34.647 -25.980 -4.523 0.50 17.65 ? 459 ARG A N 1 ATOM 3305 N N B ARG A 1 433 ? -34.634 -25.969 -4.513 0.50 17.50 ? 459 ARG A N 1 ATOM 3306 C CA A ARG A 1 433 ? -34.200 -27.171 -5.239 0.50 17.53 ? 459 ARG A CA 1 ATOM 3307 C CA B ARG A 1 433 ? -34.183 -27.135 -5.265 0.50 17.28 ? 459 ARG A CA 1 ATOM 3308 C C A ARG A 1 433 ? -32.692 -27.336 -5.060 0.50 17.40 ? 459 ARG A C 1 ATOM 3309 C C B ARG A 1 433 ? -32.680 -27.317 -5.045 0.50 17.24 ? 459 ARG A C 1 ATOM 3310 O O A ARG A 1 433 ? -31.895 -26.559 -5.595 0.50 17.42 ? 459 ARG A O 1 ATOM 3311 O O B ARG A 1 433 ? -31.869 -26.527 -5.538 0.50 17.23 ? 459 ARG A O 1 ATOM 3312 C CB A ARG A 1 433 ? -34.599 -27.113 -6.719 0.50 17.63 ? 459 ARG A CB 1 ATOM 3313 C CB B ARG A 1 433 ? -34.512 -26.971 -6.755 0.50 17.18 ? 459 ARG A CB 1 ATOM 3314 C CG A ARG A 1 433 ? -36.100 -27.293 -6.923 0.50 17.78 ? 459 ARG A CG 1 ATOM 3315 C CG B ARG A 1 433 ? -36.009 -27.034 -7.046 0.50 17.17 ? 459 ARG A CG 1 ATOM 3316 C CD A ARG A 1 433 ? -36.480 -27.760 -8.321 0.50 17.83 ? 459 ARG A CD 1 ATOM 3317 C CD B ARG A 1 433 ? -36.360 -26.692 -8.489 0.50 17.04 ? 459 ARG A CD 1 ATOM 3318 N NE A ARG A 1 433 ? -37.934 -27.829 -8.466 0.50 17.86 ? 459 ARG A NE 1 ATOM 3319 N NE B ARG A 1 433 ? -37.779 -26.364 -8.628 0.50 16.79 ? 459 ARG A NE 1 ATOM 3320 C CZ A ARG A 1 433 ? -38.664 -28.909 -8.204 0.50 17.64 ? 459 ARG A CZ 1 ATOM 3321 C CZ B ARG A 1 433 ? -38.336 -25.862 -9.725 0.50 16.58 ? 459 ARG A CZ 1 ATOM 3322 N NH1 A ARG A 1 433 ? -39.976 -28.869 -8.355 0.50 17.90 ? 459 ARG A NH1 1 ATOM 3323 N NH1 B ARG A 1 433 ? -39.635 -25.597 -9.745 0.50 16.41 ? 459 ARG A NH1 1 ATOM 3324 N NH2 A ARG A 1 433 ? -38.084 -30.032 -7.806 0.50 17.59 ? 459 ARG A NH2 1 ATOM 3325 N NH2 B ARG A 1 433 ? -37.598 -25.620 -10.798 0.50 16.47 ? 459 ARG A NH2 1 ATOM 3326 N N . LEU A 1 434 ? -32.324 -28.341 -4.271 1.00 16.97 ? 460 LEU A N 1 ATOM 3327 C CA . LEU A 1 434 ? -30.933 -28.696 -4.021 1.00 16.71 ? 460 LEU A CA 1 ATOM 3328 C C . LEU A 1 434 ? -30.604 -29.941 -4.837 1.00 16.56 ? 460 LEU A C 1 ATOM 3329 O O . LEU A 1 434 ? -31.390 -30.894 -4.873 1.00 16.52 ? 460 LEU A O 1 ATOM 3330 C CB . LEU A 1 434 ? -30.733 -28.990 -2.535 1.00 16.77 ? 460 LEU A CB 1 ATOM 3331 C CG . LEU A 1 434 ? -29.405 -29.598 -2.079 1.00 16.91 ? 460 LEU A CG 1 ATOM 3332 C CD1 . LEU A 1 434 ? -28.250 -28.629 -2.263 1.00 16.76 ? 460 LEU A CD1 1 ATOM 3333 C CD2 . LEU A 1 434 ? -29.515 -30.026 -0.621 1.00 17.00 ? 460 LEU A CD2 1 ATOM 3334 N N A ARG A 1 435 ? -29.450 -29.932 -5.493 0.50 16.26 ? 461 ARG A N 1 ATOM 3335 N N B ARG A 1 435 ? -29.449 -29.922 -5.498 0.50 16.43 ? 461 ARG A N 1 ATOM 3336 C CA A ARG A 1 435 ? -28.969 -31.103 -6.214 0.50 16.12 ? 461 ARG A CA 1 ATOM 3337 C CA B ARG A 1 435 ? -28.967 -31.065 -6.271 0.50 16.40 ? 461 ARG A CA 1 ATOM 3338 C C A ARG A 1 435 ? -27.451 -31.124 -6.210 0.50 15.99 ? 461 ARG A C 1 ATOM 3339 C C B ARG A 1 435 ? -27.451 -31.131 -6.191 0.50 16.14 ? 461 ARG A C 1 ATOM 3340 O O A ARG A 1 435 ? -26.815 -30.182 -5.742 0.50 15.92 ? 461 ARG A O 1 ATOM 3341 O O B ARG A 1 435 ? -26.816 -30.224 -5.655 0.50 16.03 ? 461 ARG A O 1 ATOM 3342 C CB A ARG A 1 435 ? -29.521 -31.129 -7.642 0.50 16.04 ? 461 ARG A CB 1 ATOM 3343 C CB B ARG A 1 435 ? -29.411 -30.956 -7.732 0.50 16.52 ? 461 ARG A CB 1 ATOM 3344 C CG A ARG A 1 435 ? -30.115 -29.816 -8.109 0.50 15.85 ? 461 ARG A CG 1 ATOM 3345 C CG B ARG A 1 435 ? -28.841 -29.758 -8.470 0.50 16.59 ? 461 ARG A CG 1 ATOM 3346 C CD A ARG A 1 435 ? -30.736 -29.950 -9.484 0.50 15.73 ? 461 ARG A CD 1 ATOM 3347 C CD B ARG A 1 435 ? -29.460 -29.611 -9.851 0.50 16.75 ? 461 ARG A CD 1 ATOM 3348 N NE A ARG A 1 435 ? -30.421 -28.778 -10.282 0.50 15.60 ? 461 ARG A NE 1 ATOM 3349 N NE B ARG A 1 435 ? -29.180 -28.305 -10.443 0.50 16.83 ? 461 ARG A NE 1 ATOM 3350 C CZ A ARG A 1 435 ? -31.246 -27.764 -10.486 0.50 15.39 ? 461 ARG A CZ 1 ATOM 3351 C CZ B ARG A 1 435 ? -28.057 -28.002 -11.081 0.50 16.72 ? 461 ARG A CZ 1 ATOM 3352 N NH1 A ARG A 1 435 ? -32.469 -27.785 -9.980 0.50 15.40 ? 461 ARG A NH1 1 ATOM 3353 N NH1 B ARG A 1 435 ? -27.107 -28.911 -11.206 0.50 16.73 ? 461 ARG A NH1 1 ATOM 3354 N NH2 A ARG A 1 435 ? -30.837 -26.745 -11.223 0.50 15.41 ? 461 ARG A NH2 1 ATOM 3355 N NH2 B ARG A 1 435 ? -27.885 -26.790 -11.594 0.50 16.86 ? 461 ARG A NH2 1 ATOM 3356 N N . GLY A 1 436 ? -26.882 -32.213 -6.712 1.00 15.93 ? 462 GLY A N 1 ATOM 3357 C CA . GLY A 1 436 ? -25.434 -32.380 -6.768 1.00 15.94 ? 462 GLY A CA 1 ATOM 3358 C C . GLY A 1 436 ? -24.778 -32.745 -5.445 1.00 16.03 ? 462 GLY A C 1 ATOM 3359 O O . GLY A 1 436 ? -23.575 -32.584 -5.295 1.00 15.92 ? 462 GLY A O 1 ATOM 3360 N N . VAL A 1 437 ? -25.559 -33.220 -4.476 1.00 15.94 ? 463 VAL A N 1 ATOM 3361 C CA . VAL A 1 437 ? -24.995 -33.683 -3.217 1.00 15.85 ? 463 VAL A CA 1 ATOM 3362 C C . VAL A 1 437 ? -24.290 -35.013 -3.498 1.00 15.89 ? 463 VAL A C 1 ATOM 3363 O O . VAL A 1 437 ? -24.919 -35.953 -3.983 1.00 15.70 ? 463 VAL A O 1 ATOM 3364 C CB . VAL A 1 437 ? -26.072 -33.865 -2.128 1.00 15.91 ? 463 VAL A CB 1 ATOM 3365 C CG1 . VAL A 1 437 ? -25.487 -34.500 -0.873 1.00 15.79 ? 463 VAL A CG1 1 ATOM 3366 C CG2 . VAL A 1 437 ? -26.720 -32.534 -1.795 1.00 16.00 ? 463 VAL A CG2 1 ATOM 3367 N N . PRO A 1 438 ? -22.979 -35.093 -3.206 1.00 15.77 ? 464 PRO A N 1 ATOM 3368 C CA . PRO A 1 438 ? -22.234 -36.314 -3.522 1.00 15.75 ? 464 PRO A CA 1 ATOM 3369 C C . PRO A 1 438 ? -22.628 -37.473 -2.616 1.00 15.62 ? 464 PRO A C 1 ATOM 3370 O O . PRO A 1 438 ? -23.174 -37.242 -1.540 1.00 15.05 ? 464 PRO A O 1 ATOM 3371 C CB . PRO A 1 438 ? -20.781 -35.914 -3.268 1.00 15.69 ? 464 PRO A CB 1 ATOM 3372 C CG . PRO A 1 438 ? -20.876 -34.860 -2.216 1.00 15.99 ? 464 PRO A CG 1 ATOM 3373 C CD . PRO A 1 438 ? -22.140 -34.100 -2.509 1.00 15.81 ? 464 PRO A CD 1 ATOM 3374 N N . PRO A 1 439 ? -22.358 -38.718 -3.050 1.00 15.90 ? 465 PRO A N 1 ATOM 3375 C CA . PRO A 1 439 ? -22.691 -39.849 -2.190 1.00 16.22 ? 465 PRO A CA 1 ATOM 3376 C C . PRO A 1 439 ? -21.910 -39.802 -0.888 1.00 16.08 ? 465 PRO A C 1 ATOM 3377 O O . PRO A 1 439 ? -20.737 -39.428 -0.882 1.00 16.33 ? 465 PRO A O 1 ATOM 3378 C CB . PRO A 1 439 ? -22.272 -41.074 -3.023 1.00 16.27 ? 465 PRO A CB 1 ATOM 3379 C CG . PRO A 1 439 ? -22.201 -40.586 -4.428 1.00 16.27 ? 465 PRO A CG 1 ATOM 3380 C CD . PRO A 1 439 ? -21.748 -39.156 -4.318 1.00 16.04 ? 465 PRO A CD 1 ATOM 3381 N N . GLY A 1 440 ? -22.561 -40.165 0.205 1.00 16.21 ? 466 GLY A N 1 ATOM 3382 C CA . GLY A 1 440 ? -21.890 -40.237 1.501 1.00 16.36 ? 466 GLY A CA 1 ATOM 3383 C C . GLY A 1 440 ? -22.629 -41.146 2.454 1.00 16.17 ? 466 GLY A C 1 ATOM 3384 O O . GLY A 1 440 ? -23.783 -41.507 2.193 1.00 16.29 ? 466 GLY A O 1 ATOM 3385 N N . PRO A 1 441 ? -21.970 -41.534 3.562 1.00 15.89 ? 467 PRO A N 1 ATOM 3386 C CA . PRO A 1 441 ? -22.644 -42.343 4.575 1.00 15.75 ? 467 PRO A CA 1 ATOM 3387 C C . PRO A 1 441 ? -23.652 -41.535 5.398 1.00 15.56 ? 467 PRO A C 1 ATOM 3388 O O . PRO A 1 441 ? -23.382 -40.385 5.761 1.00 15.84 ? 467 PRO A O 1 ATOM 3389 C CB . PRO A 1 441 ? -21.493 -42.830 5.461 1.00 15.87 ? 467 PRO A CB 1 ATOM 3390 C CG . PRO A 1 441 ? -20.425 -41.797 5.304 1.00 15.98 ? 467 PRO A CG 1 ATOM 3391 C CD . PRO A 1 441 ? -20.552 -41.289 3.893 1.00 15.92 ? 467 PRO A CD 1 ATOM 3392 N N . GLY A 1 442 ? -24.803 -42.142 5.669 1.00 15.02 ? 468 GLY A N 1 ATOM 3393 C CA . GLY A 1 442 ? -25.810 -41.582 6.569 1.00 14.86 ? 468 GLY A CA 1 ATOM 3394 C C . GLY A 1 442 ? -26.180 -40.126 6.351 1.00 14.69 ? 468 GLY A C 1 ATOM 3395 O O . GLY A 1 442 ? -26.324 -39.375 7.314 1.00 14.77 ? 468 GLY A O 1 ATOM 3396 N N . LEU A 1 443 ? -26.350 -39.730 5.093 1.00 14.41 ? 469 LEU A N 1 ATOM 3397 C CA . LEU A 1 443 ? -26.706 -38.356 4.757 1.00 14.28 ? 469 LEU A CA 1 ATOM 3398 C C . LEU A 1 443 ? -28.055 -37.963 5.357 1.00 14.26 ? 469 LEU A C 1 ATOM 3399 O O . LEU A 1 443 ? -29.062 -38.634 5.126 1.00 14.26 ? 469 LEU A O 1 ATOM 3400 C CB . LEU A 1 443 ? -26.742 -38.163 3.240 1.00 14.31 ? 469 LEU A CB 1 ATOM 3401 C CG . LEU A 1 443 ? -25.368 -38.054 2.580 1.00 14.29 ? 469 LEU A CG 1 ATOM 3402 C CD1 . LEU A 1 443 ? -25.458 -38.410 1.107 1.00 14.38 ? 469 LEU A CD1 1 ATOM 3403 C CD2 . LEU A 1 443 ? -24.796 -36.658 2.771 1.00 14.30 ? 469 LEU A CD2 1 ATOM 3404 N N . VAL A 1 444 ? -28.056 -36.882 6.136 1.00 13.98 ? 470 VAL A N 1 ATOM 3405 C CA . VAL A 1 444 ? -29.274 -36.340 6.732 1.00 13.67 ? 470 VAL A CA 1 ATOM 3406 C C . VAL A 1 444 ? -29.364 -34.841 6.474 1.00 13.49 ? 470 VAL A C 1 ATOM 3407 O O . VAL A 1 444 ? -28.365 -34.199 6.151 1.00 13.11 ? 470 VAL A O 1 ATOM 3408 C CB . VAL A 1 444 ? -29.349 -36.595 8.257 1.00 13.82 ? 470 VAL A CB 1 ATOM 3409 C CG1 . VAL A 1 444 ? -29.446 -38.089 8.547 1.00 13.84 ? 470 VAL A CG1 1 ATOM 3410 C CG2 . VAL A 1 444 ? -28.159 -35.979 8.990 1.00 13.77 ? 470 VAL A CG2 1 ATOM 3411 N N . TYR A 1 445 ? -30.572 -34.296 6.595 1.00 13.39 ? 471 TYR A N 1 ATOM 3412 C CA . TYR A 1 445 ? -30.770 -32.851 6.551 1.00 13.12 ? 471 TYR A CA 1 ATOM 3413 C C . TYR A 1 445 ? -31.603 -32.379 7.736 1.00 13.31 ? 471 TYR A C 1 ATOM 3414 O O . TYR A 1 445 ? -32.507 -33.086 8.211 1.00 12.96 ? 471 TYR A O 1 ATOM 3415 C CB . TYR A 1 445 ? -31.394 -32.394 5.223 1.00 12.93 ? 471 TYR A CB 1 ATOM 3416 C CG . TYR A 1 445 ? -32.775 -32.941 4.933 1.00 12.79 ? 471 TYR A CG 1 ATOM 3417 C CD1 . TYR A 1 445 ? -32.937 -34.220 4.423 1.00 12.63 ? 471 TYR A CD1 1 ATOM 3418 C CD2 . TYR A 1 445 ? -33.920 -32.168 5.148 1.00 12.72 ? 471 TYR A CD2 1 ATOM 3419 C CE1 . TYR A 1 445 ? -34.194 -34.725 4.145 1.00 12.68 ? 471 TYR A CE1 1 ATOM 3420 C CE2 . TYR A 1 445 ? -35.187 -32.666 4.867 1.00 12.56 ? 471 TYR A CE2 1 ATOM 3421 C CZ . TYR A 1 445 ? -35.315 -33.946 4.366 1.00 12.54 ? 471 TYR A CZ 1 ATOM 3422 O OH . TYR A 1 445 ? -36.554 -34.476 4.087 1.00 12.53 ? 471 TYR A OH 1 ATOM 3423 N N . VAL A 1 446 ? -31.270 -31.176 8.199 1.00 13.44 ? 472 VAL A N 1 ATOM 3424 C CA . VAL A 1 446 ? -31.890 -30.552 9.358 1.00 13.58 ? 472 VAL A CA 1 ATOM 3425 C C . VAL A 1 446 ? -32.192 -29.114 8.970 1.00 13.84 ? 472 VAL A C 1 ATOM 3426 O O . VAL A 1 446 ? -31.312 -28.411 8.478 1.00 14.02 ? 472 VAL A O 1 ATOM 3427 C CB . VAL A 1 446 ? -30.940 -30.568 10.580 1.00 13.42 ? 472 VAL A CB 1 ATOM 3428 C CG1 . VAL A 1 446 ? -31.435 -29.646 11.684 1.00 13.41 ? 472 VAL A CG1 1 ATOM 3429 C CG2 . VAL A 1 446 ? -30.778 -31.982 11.112 1.00 13.36 ? 472 VAL A CG2 1 ATOM 3430 N N . THR A 1 447 ? -33.436 -28.693 9.172 1.00 14.02 ? 473 THR A N 1 ATOM 3431 C CA . THR A 1 447 ? -33.834 -27.325 8.891 1.00 14.31 ? 473 THR A CA 1 ATOM 3432 C C . THR A 1 447 ? -33.929 -26.569 10.196 1.00 14.50 ? 473 THR A C 1 ATOM 3433 O O . THR A 1 447 ? -34.386 -27.114 11.202 1.00 14.72 ? 473 THR A O 1 ATOM 3434 C CB . THR A 1 447 ? -35.198 -27.266 8.196 1.00 14.32 ? 473 THR A CB 1 ATOM 3435 O OG1 . THR A 1 447 ? -36.166 -27.947 9.000 1.00 14.66 ? 473 THR A OG1 1 ATOM 3436 C CG2 . THR A 1 447 ? -35.121 -27.926 6.831 1.00 14.35 ? 473 THR A CG2 1 ATOM 3437 N N . ARG A 1 448 ? -33.477 -25.322 10.182 1.00 14.68 ? 474 ARG A N 1 ATOM 3438 C CA . ARG A 1 448 ? -33.645 -24.426 11.315 1.00 14.86 ? 474 ARG A CA 1 ATOM 3439 C C . ARG A 1 448 ? -34.288 -23.154 10.801 1.00 14.79 ? 474 ARG A C 1 ATOM 3440 O O . ARG A 1 448 ? -33.812 -22.565 9.830 1.00 14.98 ? 474 ARG A O 1 ATOM 3441 C CB . ARG A 1 448 ? -32.300 -24.125 11.970 1.00 15.05 ? 474 ARG A CB 1 ATOM 3442 C CG . ARG A 1 448 ? -31.770 -25.267 12.813 1.00 15.44 ? 474 ARG A CG 1 ATOM 3443 C CD . ARG A 1 448 ? -30.383 -24.965 13.341 1.00 15.85 ? 474 ARG A CD 1 ATOM 3444 N NE . ARG A 1 448 ? -29.884 -26.052 14.179 1.00 16.27 ? 474 ARG A NE 1 ATOM 3445 C CZ . ARG A 1 448 ? -29.029 -27.000 13.797 1.00 16.57 ? 474 ARG A CZ 1 ATOM 3446 N NH1 . ARG A 1 448 ? -28.527 -27.034 12.561 1.00 16.75 ? 474 ARG A NH1 1 ATOM 3447 N NH2 . ARG A 1 448 ? -28.666 -27.929 14.674 1.00 16.79 ? 474 ARG A NH2 1 ATOM 3448 N N . TYR A 1 449 ? -35.371 -22.737 11.446 1.00 14.73 ? 475 TYR A N 1 ATOM 3449 C CA . TYR A 1 449 ? -36.179 -21.635 10.943 1.00 14.62 ? 475 TYR A CA 1 ATOM 3450 C C . TYR A 1 449 ? -36.370 -20.556 12.004 1.00 14.54 ? 475 TYR A C 1 ATOM 3451 O O . TYR A 1 449 ? -36.575 -20.854 13.186 1.00 14.36 ? 475 TYR A O 1 ATOM 3452 C CB . TYR A 1 449 ? -37.526 -22.161 10.463 1.00 14.60 ? 475 TYR A CB 1 ATOM 3453 C CG . TYR A 1 449 ? -38.478 -21.075 10.027 1.00 14.76 ? 475 TYR A CG 1 ATOM 3454 C CD1 . TYR A 1 449 ? -38.251 -20.348 8.863 1.00 14.79 ? 475 TYR A CD1 1 ATOM 3455 C CD2 . TYR A 1 449 ? -39.610 -20.775 10.778 1.00 14.80 ? 475 TYR A CD2 1 ATOM 3456 C CE1 . TYR A 1 449 ? -39.126 -19.353 8.463 1.00 14.80 ? 475 TYR A CE1 1 ATOM 3457 C CE2 . TYR A 1 449 ? -40.488 -19.785 10.385 1.00 14.93 ? 475 TYR A CE2 1 ATOM 3458 C CZ . TYR A 1 449 ? -40.239 -19.077 9.227 1.00 14.93 ? 475 TYR A CZ 1 ATOM 3459 O OH . TYR A 1 449 ? -41.108 -18.092 8.834 1.00 15.27 ? 475 TYR A OH 1 ATOM 3460 N N . LEU A 1 450 ? -36.320 -19.303 11.563 1.00 14.48 ? 476 LEU A N 1 ATOM 3461 C CA . LEU A 1 450 ? -36.387 -18.154 12.459 1.00 14.62 ? 476 LEU A CA 1 ATOM 3462 C C . LEU A 1 450 ? -37.345 -17.098 11.906 1.00 14.53 ? 476 LEU A C 1 ATOM 3463 O O . LEU A 1 450 ? -37.190 -16.662 10.765 1.00 14.34 ? 476 LEU A O 1 ATOM 3464 C CB . LEU A 1 450 ? -34.984 -17.571 12.601 1.00 14.92 ? 476 LEU A CB 1 ATOM 3465 C CG . LEU A 1 450 ? -34.582 -16.864 13.892 1.00 15.30 ? 476 LEU A CG 1 ATOM 3466 C CD1 . LEU A 1 450 ? -34.533 -17.817 15.076 1.00 15.21 ? 476 LEU A CD1 1 ATOM 3467 C CD2 . LEU A 1 450 ? -33.223 -16.208 13.677 1.00 15.60 ? 476 LEU A CD2 1 ATOM 3468 N N . ASP A 1 451 ? -38.347 -16.712 12.697 1.00 14.33 ? 477 ASP A N 1 ATOM 3469 C CA . ASP A 1 451 ? -39.212 -15.582 12.346 1.00 14.28 ? 477 ASP A CA 1 ATOM 3470 C C . ASP A 1 451 ? -39.822 -14.908 13.582 1.00 14.41 ? 477 ASP A C 1 ATOM 3471 O O . ASP A 1 451 ? -39.633 -15.378 14.705 1.00 14.10 ? 477 ASP A O 1 ATOM 3472 C CB . ASP A 1 451 ? -40.276 -15.981 11.304 1.00 14.29 ? 477 ASP A CB 1 ATOM 3473 C CG . ASP A 1 451 ? -41.471 -16.730 11.891 1.00 14.12 ? 477 ASP A CG 1 ATOM 3474 O OD1 . ASP A 1 451 ? -41.649 -16.798 13.120 1.00 14.17 ? 477 ASP A OD1 1 ATOM 3475 O OD2 . ASP A 1 451 ? -42.264 -17.245 11.084 1.00 14.18 ? 477 ASP A OD2 1 ATOM 3476 N N . ASN A 1 452 ? -40.524 -13.795 13.371 1.00 14.49 ? 478 ASN A N 1 ATOM 3477 C CA . ASN A 1 452 ? -41.040 -13.000 14.487 1.00 14.95 ? 478 ASN A CA 1 ATOM 3478 C C . ASN A 1 452 ? -42.199 -13.638 15.222 1.00 15.19 ? 478 ASN A C 1 ATOM 3479 O O . ASN A 1 452 ? -42.402 -13.353 16.392 1.00 15.33 ? 478 ASN A O 1 ATOM 3480 C CB . ASN A 1 452 ? -41.436 -11.587 14.035 1.00 14.84 ? 478 ASN A CB 1 ATOM 3481 C CG . ASN A 1 452 ? -40.233 -10.705 13.778 1.00 14.71 ? 478 ASN A CG 1 ATOM 3482 O OD1 . ASN A 1 452 ? -39.157 -10.946 14.319 1.00 14.44 ? 478 ASN A OD1 1 ATOM 3483 N ND2 . ASN A 1 452 ? -40.409 -9.676 12.955 1.00 14.61 ? 478 ASN A ND2 1 ATOM 3484 N N . GLY A 1 453 ? -42.947 -14.503 14.543 1.00 15.83 ? 479 GLY A N 1 ATOM 3485 C CA . GLY A 1 453 ? -44.088 -15.188 15.162 1.00 16.03 ? 479 GLY A CA 1 ATOM 3486 C C . GLY A 1 453 ? -43.680 -16.274 16.140 1.00 16.20 ? 479 GLY A C 1 ATOM 3487 O O . GLY A 1 453 ? -44.335 -16.474 17.162 1.00 16.72 ? 479 GLY A O 1 ATOM 3488 N N . LEU A 1 454 ? -42.597 -16.982 15.831 1.00 16.21 ? 480 LEU A N 1 ATOM 3489 C CA . LEU A 1 454 ? -42.173 -18.132 16.634 1.00 16.09 ? 480 LEU A CA 1 ATOM 3490 C C . LEU A 1 454 ? -40.898 -17.892 17.446 1.00 15.47 ? 480 LEU A C 1 ATOM 3491 O O . LEU A 1 454 ? -40.703 -18.527 18.475 1.00 15.47 ? 480 LEU A O 1 ATOM 3492 C CB . LEU A 1 454 ? -41.973 -19.346 15.720 1.00 16.57 ? 480 LEU A CB 1 ATOM 3493 C CG . LEU A 1 454 ? -43.241 -19.847 15.017 1.00 17.05 ? 480 LEU A CG 1 ATOM 3494 C CD1 . LEU A 1 454 ? -42.904 -20.661 13.776 1.00 17.20 ? 480 LEU A CD1 1 ATOM 3495 C CD2 . LEU A 1 454 ? -44.095 -20.670 15.975 1.00 17.24 ? 480 LEU A CD2 1 ATOM 3496 N N . CYS A 1 455 ? -40.028 -16.992 16.991 1.00 14.77 ? 481 CYS A N 1 ATOM 3497 C CA . CYS A 1 455 ? -38.697 -16.871 17.583 1.00 14.40 ? 481 CYS A CA 1 ATOM 3498 C C . CYS A 1 455 ? -38.326 -15.442 18.000 1.00 14.12 ? 481 CYS A C 1 ATOM 3499 O O . CYS A 1 455 ? -37.193 -14.991 17.787 1.00 13.82 ? 481 CYS A O 1 ATOM 3500 C CB . CYS A 1 455 ? -37.659 -17.438 16.613 1.00 14.37 ? 481 CYS A CB 1 ATOM 3501 S SG . CYS A 1 455 ? -38.058 -19.113 16.062 1.00 14.39 ? 481 CYS A SG 1 ATOM 3502 N N . SER A 1 456 ? -39.272 -14.743 18.625 1.00 13.86 ? 482 SER A N 1 ATOM 3503 C CA . SER A 1 456 ? -39.008 -13.396 19.124 1.00 13.55 ? 482 SER A CA 1 ATOM 3504 C C . SER A 1 456 ? -39.281 -13.274 20.617 1.00 13.37 ? 482 SER A C 1 ATOM 3505 O O . SER A 1 456 ? -40.433 -13.174 21.032 1.00 13.27 ? 482 SER A O 1 ATOM 3506 C CB . SER A 1 456 ? -39.832 -12.354 18.365 1.00 13.45 ? 482 SER A CB 1 ATOM 3507 O OG . SER A 1 456 ? -39.466 -11.050 18.784 1.00 13.16 ? 482 SER A OG 1 ATOM 3508 N N . PRO A 1 457 ? -38.215 -13.268 21.432 1.00 13.25 ? 483 PRO A N 1 ATOM 3509 C CA . PRO A 1 457 ? -38.362 -12.941 22.847 1.00 13.26 ? 483 PRO A CA 1 ATOM 3510 C C . PRO A 1 457 ? -39.012 -11.570 23.079 1.00 13.43 ? 483 PRO A C 1 ATOM 3511 O O . PRO A 1 457 ? -39.763 -11.409 24.036 1.00 13.13 ? 483 PRO A O 1 ATOM 3512 C CB . PRO A 1 457 ? -36.924 -12.963 23.356 1.00 13.23 ? 483 PRO A CB 1 ATOM 3513 C CG . PRO A 1 457 ? -36.234 -13.936 22.463 1.00 13.16 ? 483 PRO A CG 1 ATOM 3514 C CD . PRO A 1 457 ? -36.851 -13.732 21.114 1.00 13.18 ? 483 PRO A CD 1 ATOM 3515 N N . ASP A 1 458 ? -38.744 -10.600 22.206 1.00 13.84 ? 484 ASP A N 1 ATOM 3516 C CA . ASP A 1 458 ? -39.453 -9.316 22.267 1.00 14.24 ? 484 ASP A CA 1 ATOM 3517 C C . ASP A 1 458 ? -40.948 -9.533 22.052 1.00 14.50 ? 484 ASP A C 1 ATOM 3518 O O . ASP A 1 458 ? -41.764 -8.958 22.756 1.00 14.50 ? 484 ASP A O 1 ATOM 3519 C CB . ASP A 1 458 ? -38.929 -8.336 21.218 1.00 14.23 ? 484 ASP A CB 1 ATOM 3520 C CG . ASP A 1 458 ? -39.657 -7.000 21.257 1.00 14.30 ? 484 ASP A CG 1 ATOM 3521 O OD1 . ASP A 1 458 ? -39.606 -6.330 22.310 1.00 14.29 ? 484 ASP A OD1 1 ATOM 3522 O OD2 . ASP A 1 458 ? -40.278 -6.624 20.241 1.00 14.36 ? 484 ASP A OD2 1 ATOM 3523 N N . GLY A 1 459 ? -41.289 -10.371 21.076 1.00 14.94 ? 485 GLY A N 1 ATOM 3524 C CA . GLY A 1 459 ? -42.679 -10.745 20.804 1.00 15.41 ? 485 GLY A CA 1 ATOM 3525 C C . GLY A 1 459 ? -43.408 -11.346 21.998 1.00 15.69 ? 485 GLY A C 1 ATOM 3526 O O . GLY A 1 459 ? -44.580 -11.035 22.240 1.00 15.60 ? 485 GLY A O 1 ATOM 3527 N N A GLU A 1 460 ? -42.716 -12.213 22.734 0.50 15.90 ? 486 GLU A N 1 ATOM 3528 N N B GLU A 1 460 ? -42.721 -12.212 22.738 0.50 15.85 ? 486 GLU A N 1 ATOM 3529 C CA A GLU A 1 460 ? -43.260 -12.805 23.953 0.50 16.10 ? 486 GLU A CA 1 ATOM 3530 C CA B GLU A 1 460 ? -43.281 -12.796 23.954 0.50 16.04 ? 486 GLU A CA 1 ATOM 3531 C C A GLU A 1 460 ? -43.376 -11.751 25.054 0.50 16.27 ? 486 GLU A C 1 ATOM 3532 C C B GLU A 1 460 ? -43.379 -11.748 25.060 0.50 16.23 ? 486 GLU A C 1 ATOM 3533 O O A GLU A 1 460 ? -44.341 -11.749 25.811 0.50 16.13 ? 486 GLU A O 1 ATOM 3534 O O B GLU A 1 460 ? -44.334 -11.748 25.829 0.50 16.13 ? 486 GLU A O 1 ATOM 3535 C CB A GLU A 1 460 ? -42.379 -13.964 24.426 0.50 16.14 ? 486 GLU A CB 1 ATOM 3536 C CB B GLU A 1 460 ? -42.438 -13.983 24.423 0.50 16.03 ? 486 GLU A CB 1 ATOM 3537 C CG A GLU A 1 460 ? -42.139 -15.036 23.373 0.50 16.24 ? 486 GLU A CG 1 ATOM 3538 C CG B GLU A 1 460 ? -42.967 -14.659 25.680 0.50 16.07 ? 486 GLU A CG 1 ATOM 3539 C CD A GLU A 1 460 ? -43.403 -15.785 22.996 0.50 16.20 ? 486 GLU A CD 1 ATOM 3540 C CD B GLU A 1 460 ? -44.399 -15.138 25.534 0.50 16.04 ? 486 GLU A CD 1 ATOM 3541 O OE1 A GLU A 1 460 ? -43.505 -16.238 21.838 0.50 16.15 ? 486 GLU A OE1 1 ATOM 3542 O OE1 B GLU A 1 460 ? -44.857 -15.296 24.386 0.50 16.18 ? 486 GLU A OE1 1 ATOM 3543 O OE2 A GLU A 1 460 ? -44.293 -15.915 23.862 0.50 16.15 ? 486 GLU A OE2 1 ATOM 3544 O OE2 B GLU A 1 460 ? -45.066 -15.361 26.565 0.50 15.89 ? 486 GLU A OE2 1 ATOM 3545 N N . TRP A 1 461 ? -42.391 -10.860 25.135 1.00 16.55 ? 487 TRP A N 1 ATOM 3546 C CA . TRP A 1 461 ? -42.408 -9.767 26.112 1.00 17.43 ? 487 TRP A CA 1 ATOM 3547 C C . TRP A 1 461 ? -43.637 -8.869 25.909 1.00 18.71 ? 487 TRP A C 1 ATOM 3548 O O . TRP A 1 461 ? -44.328 -8.550 26.869 1.00 18.27 ? 487 TRP A O 1 ATOM 3549 C CB . TRP A 1 461 ? -41.117 -8.942 26.028 1.00 17.15 ? 487 TRP A CB 1 ATOM 3550 C CG . TRP A 1 461 ? -40.988 -7.895 27.093 1.00 17.11 ? 487 TRP A CG 1 ATOM 3551 C CD1 . TRP A 1 461 ? -41.056 -8.091 28.439 1.00 16.98 ? 487 TRP A CD1 1 ATOM 3552 C CD2 . TRP A 1 461 ? -40.741 -6.490 26.902 1.00 16.86 ? 487 TRP A CD2 1 ATOM 3553 N NE1 . TRP A 1 461 ? -40.881 -6.897 29.099 1.00 17.09 ? 487 TRP A NE1 1 ATOM 3554 C CE2 . TRP A 1 461 ? -40.682 -5.901 28.180 1.00 16.78 ? 487 TRP A CE2 1 ATOM 3555 C CE3 . TRP A 1 461 ? -40.566 -5.677 25.776 1.00 16.81 ? 487 TRP A CE3 1 ATOM 3556 C CZ2 . TRP A 1 461 ? -40.461 -4.532 28.366 1.00 16.77 ? 487 TRP A CZ2 1 ATOM 3557 C CZ3 . TRP A 1 461 ? -40.346 -4.315 25.961 1.00 16.61 ? 487 TRP A CZ3 1 ATOM 3558 C CH2 . TRP A 1 461 ? -40.292 -3.759 27.246 1.00 16.56 ? 487 TRP A CH2 1 ATOM 3559 N N . ARG A 1 462 ? -43.908 -8.493 24.658 1.00 20.98 ? 488 ARG A N 1 ATOM 3560 C CA . ARG A 1 462 ? -45.092 -7.691 24.320 1.00 22.84 ? 488 ARG A CA 1 ATOM 3561 C C . ARG A 1 462 ? -46.385 -8.430 24.646 1.00 22.65 ? 488 ARG A C 1 ATOM 3562 O O . ARG A 1 462 ? -47.295 -7.870 25.260 1.00 21.55 ? 488 ARG A O 1 ATOM 3563 C CB . ARG A 1 462 ? -45.087 -7.262 22.840 1.00 24.66 ? 488 ARG A CB 1 ATOM 3564 C CG . ARG A 1 462 ? -44.488 -5.874 22.596 1.00 26.86 ? 488 ARG A CG 1 ATOM 3565 C CD . ARG A 1 462 ? -43.156 -5.883 21.853 1.00 28.75 ? 488 ARG A CD 1 ATOM 3566 N NE . ARG A 1 462 ? -43.305 -5.412 20.469 1.00 30.13 ? 488 ARG A NE 1 ATOM 3567 C CZ . ARG A 1 462 ? -43.621 -6.168 19.415 1.00 30.94 ? 488 ARG A CZ 1 ATOM 3568 N NH1 . ARG A 1 462 ? -43.826 -7.470 19.538 1.00 31.92 ? 488 ARG A NH1 1 ATOM 3569 N NH2 . ARG A 1 462 ? -43.733 -5.610 18.213 1.00 31.84 ? 488 ARG A NH2 1 ATOM 3570 N N . ARG A 1 463 ? -46.454 -9.693 24.248 1.00 22.93 ? 489 ARG A N 1 ATOM 3571 C CA . ARG A 1 463 ? -47.602 -10.534 24.559 1.00 23.90 ? 489 ARG A CA 1 ATOM 3572 C C . ARG A 1 463 ? -47.849 -10.615 26.072 1.00 23.00 ? 489 ARG A C 1 ATOM 3573 O O . ARG A 1 463 ? -48.986 -10.754 26.503 1.00 23.29 ? 489 ARG A O 1 ATOM 3574 C CB . ARG A 1 463 ? -47.403 -11.933 23.973 1.00 25.89 ? 489 ARG A CB 1 ATOM 3575 C CG . ARG A 1 463 ? -48.630 -12.827 24.041 1.00 28.23 ? 489 ARG A CG 1 ATOM 3576 C CD . ARG A 1 463 ? -48.278 -14.307 23.908 1.00 30.35 ? 489 ARG A CD 1 ATOM 3577 N NE . ARG A 1 463 ? -49.164 -15.133 24.735 1.00 32.38 ? 489 ARG A NE 1 ATOM 3578 C CZ . ARG A 1 463 ? -48.923 -15.509 25.996 1.00 33.75 ? 489 ARG A CZ 1 ATOM 3579 N NH1 . ARG A 1 463 ? -49.822 -16.255 26.635 1.00 35.49 ? 489 ARG A NH1 1 ATOM 3580 N NH2 . ARG A 1 463 ? -47.799 -15.161 26.628 1.00 33.19 ? 489 ARG A NH2 1 ATOM 3581 N N . LEU A 1 464 ? -46.790 -10.518 26.874 1.00 21.95 ? 490 LEU A N 1 ATOM 3582 C CA . LEU A 1 464 ? -46.928 -10.501 28.334 1.00 21.36 ? 490 LEU A CA 1 ATOM 3583 C C . LEU A 1 464 ? -47.313 -9.131 28.915 1.00 20.74 ? 490 LEU A C 1 ATOM 3584 O O . LEU A 1 464 ? -47.493 -9.004 30.121 1.00 20.45 ? 490 LEU A O 1 ATOM 3585 C CB . LEU A 1 464 ? -45.641 -11.000 28.994 1.00 21.22 ? 490 LEU A CB 1 ATOM 3586 C CG . LEU A 1 464 ? -45.345 -12.490 28.793 1.00 21.36 ? 490 LEU A CG 1 ATOM 3587 C CD1 . LEU A 1 464 ? -43.879 -12.781 29.068 1.00 21.37 ? 490 LEU A CD1 1 ATOM 3588 C CD2 . LEU A 1 464 ? -46.240 -13.357 29.670 1.00 21.44 ? 490 LEU A CD2 1 ATOM 3589 N N . GLY A 1 465 ? -47.448 -8.119 28.066 1.00 20.63 ? 491 GLY A N 1 ATOM 3590 C CA . GLY A 1 465 ? -47.768 -6.760 28.516 1.00 20.62 ? 491 GLY A CA 1 ATOM 3591 C C . GLY A 1 465 ? -46.537 -5.929 28.833 1.00 20.35 ? 491 GLY A C 1 ATOM 3592 O O . GLY A 1 465 ? -46.628 -4.941 29.556 1.00 20.05 ? 491 GLY A O 1 ATOM 3593 N N . ARG A 1 466 ? -45.388 -6.329 28.288 1.00 20.51 ? 492 ARG A N 1 ATOM 3594 C CA . ARG A 1 466 ? -44.118 -5.620 28.488 1.00 20.57 ? 492 ARG A CA 1 ATOM 3595 C C . ARG A 1 466 ? -43.815 -5.315 29.960 1.00 19.64 ? 492 ARG A C 1 ATOM 3596 O O . ARG A 1 466 ? -43.573 -4.164 30.319 1.00 19.28 ? 492 ARG A O 1 ATOM 3597 C CB . ARG A 1 466 ? -44.093 -4.320 27.665 1.00 21.81 ? 492 ARG A CB 1 ATOM 3598 C CG . ARG A 1 466 ? -44.289 -4.525 26.174 1.00 22.81 ? 492 ARG A CG 1 ATOM 3599 C CD . ARG A 1 466 ? -44.517 -3.222 25.422 1.00 23.92 ? 492 ARG A CD 1 ATOM 3600 N NE . ARG A 1 466 ? -43.275 -2.531 25.070 1.00 25.27 ? 492 ARG A NE 1 ATOM 3601 C CZ . ARG A 1 466 ? -42.748 -1.478 25.712 1.00 25.87 ? 492 ARG A CZ 1 ATOM 3602 N NH1 . ARG A 1 466 ? -43.337 -0.939 26.790 1.00 26.33 ? 492 ARG A NH1 1 ATOM 3603 N NH2 . ARG A 1 466 ? -41.608 -0.953 25.266 1.00 25.05 ? 492 ARG A NH2 1 ATOM 3604 N N . PRO A 1 467 ? -43.816 -6.348 30.820 1.00 19.07 ? 493 PRO A N 1 ATOM 3605 C CA . PRO A 1 467 ? -43.496 -6.114 32.233 1.00 18.80 ? 493 PRO A CA 1 ATOM 3606 C C . PRO A 1 467 ? -42.109 -5.501 32.429 1.00 18.04 ? 493 PRO A C 1 ATOM 3607 O O . PRO A 1 467 ? -41.155 -5.906 31.765 1.00 17.85 ? 493 PRO A O 1 ATOM 3608 C CB . PRO A 1 467 ? -43.563 -7.519 32.856 1.00 18.85 ? 493 PRO A CB 1 ATOM 3609 C CG . PRO A 1 467 ? -43.456 -8.465 31.711 1.00 18.98 ? 493 PRO A CG 1 ATOM 3610 C CD . PRO A 1 467 ? -44.090 -7.769 30.548 1.00 18.96 ? 493 PRO A CD 1 ATOM 3611 N N . VAL A 1 468 ? -42.019 -4.536 33.341 1.00 17.43 ? 494 VAL A N 1 ATOM 3612 C CA . VAL A 1 468 ? -40.785 -3.793 33.602 1.00 16.97 ? 494 VAL A CA 1 ATOM 3613 C C . VAL A 1 468 ? -39.804 -4.671 34.375 1.00 16.51 ? 494 VAL A C 1 ATOM 3614 O O . VAL A 1 468 ? -38.604 -4.652 34.115 1.00 15.84 ? 494 VAL A O 1 ATOM 3615 C CB . VAL A 1 468 ? -41.077 -2.505 34.407 1.00 17.34 ? 494 VAL A CB 1 ATOM 3616 C CG1 . VAL A 1 468 ? -39.793 -1.765 34.745 1.00 17.43 ? 494 VAL A CG1 1 ATOM 3617 C CG2 . VAL A 1 468 ? -42.020 -1.585 33.630 1.00 17.55 ? 494 VAL A CG2 1 ATOM 3618 N N . PHE A 1 469 ? -40.335 -5.419 35.340 1.00 15.89 ? 495 PHE A N 1 ATOM 3619 C CA . PHE A 1 469 ? -39.574 -6.390 36.098 1.00 15.62 ? 495 PHE A CA 1 ATOM 3620 C C . PHE A 1 469 ? -40.221 -7.750 35.897 1.00 15.14 ? 495 PHE A C 1 ATOM 3621 O O . PHE A 1 469 ? -41.053 -8.163 36.696 1.00 14.75 ? 495 PHE A O 1 ATOM 3622 C CB . PHE A 1 469 ? -39.557 -6.020 37.582 1.00 15.89 ? 495 PHE A CB 1 ATOM 3623 C CG . PHE A 1 469 ? -39.001 -4.653 37.856 1.00 16.03 ? 495 PHE A CG 1 ATOM 3624 C CD1 . PHE A 1 469 ? -37.729 -4.308 37.418 1.00 16.13 ? 495 PHE A CD1 1 ATOM 3625 C CD2 . PHE A 1 469 ? -39.749 -3.711 38.553 1.00 16.27 ? 495 PHE A CD2 1 ATOM 3626 C CE1 . PHE A 1 469 ? -37.211 -3.040 37.666 1.00 16.42 ? 495 PHE A CE1 1 ATOM 3627 C CE2 . PHE A 1 469 ? -39.240 -2.440 38.804 1.00 16.31 ? 495 PHE A CE2 1 ATOM 3628 C CZ . PHE A 1 469 ? -37.966 -2.108 38.367 1.00 16.31 ? 495 PHE A CZ 1 ATOM 3629 N N . PRO A 1 470 ? -39.846 -8.453 34.816 1.00 14.78 ? 496 PRO A N 1 ATOM 3630 C CA . PRO A 1 470 ? -40.497 -9.737 34.569 1.00 14.58 ? 496 PRO A CA 1 ATOM 3631 C C . PRO A 1 470 ? -40.264 -10.719 35.710 1.00 14.45 ? 496 PRO A C 1 ATOM 3632 O O . PRO A 1 470 ? -39.207 -10.697 36.344 1.00 13.92 ? 496 PRO A O 1 ATOM 3633 C CB . PRO A 1 470 ? -39.836 -10.235 33.278 1.00 14.63 ? 496 PRO A CB 1 ATOM 3634 C CG . PRO A 1 470 ? -39.224 -9.023 32.654 1.00 14.60 ? 496 PRO A CG 1 ATOM 3635 C CD . PRO A 1 470 ? -38.827 -8.148 33.800 1.00 14.57 ? 496 PRO A CD 1 ATOM 3636 N N . THR A 1 471 ? -41.270 -11.546 35.975 1.00 14.36 ? 497 THR A N 1 ATOM 3637 C CA . THR A 1 471 ? -41.166 -12.608 36.963 1.00 14.51 ? 497 THR A CA 1 ATOM 3638 C C . THR A 1 471 ? -40.296 -13.720 36.391 1.00 14.35 ? 497 THR A C 1 ATOM 3639 O O . THR A 1 471 ? -39.998 -13.734 35.197 1.00 13.86 ? 497 THR A O 1 ATOM 3640 C CB . THR A 1 471 ? -42.549 -13.200 37.304 1.00 14.45 ? 497 THR A CB 1 ATOM 3641 O OG1 . THR A 1 471 ? -43.130 -13.752 36.116 1.00 14.35 ? 497 THR A OG1 1 ATOM 3642 C CG2 . THR A 1 471 ? -43.489 -12.122 37.875 1.00 14.42 ? 497 THR A CG2 1 ATOM 3643 N N . ALA A 1 472 ? -39.891 -14.652 37.244 1.00 14.50 ? 498 ALA A N 1 ATOM 3644 C CA . ALA A 1 472 ? -39.103 -15.796 36.791 1.00 14.84 ? 498 ALA A CA 1 ATOM 3645 C C . ALA A 1 472 ? -39.834 -16.586 35.704 1.00 15.09 ? 498 ALA A C 1 ATOM 3646 O O . ALA A 1 472 ? -39.208 -17.079 34.769 1.00 15.01 ? 498 ALA A O 1 ATOM 3647 C CB . ALA A 1 472 ? -38.755 -16.699 37.963 1.00 14.70 ? 498 ALA A CB 1 ATOM 3648 N N . GLU A 1 473 ? -41.155 -16.696 35.820 1.00 15.61 ? 499 GLU A N 1 ATOM 3649 C CA . GLU A 1 473 ? -41.941 -17.478 34.864 1.00 16.20 ? 499 GLU A CA 1 ATOM 3650 C C . GLU A 1 473 ? -42.040 -16.737 33.538 1.00 15.70 ? 499 GLU A C 1 ATOM 3651 O O . GLU A 1 473 ? -42.005 -17.352 32.475 1.00 15.98 ? 499 GLU A O 1 ATOM 3652 C CB . GLU A 1 473 ? -43.338 -17.805 35.418 1.00 17.02 ? 499 GLU A CB 1 ATOM 3653 C CG . GLU A 1 473 ? -44.155 -18.785 34.569 1.00 17.89 ? 499 GLU A CG 1 ATOM 3654 C CD . GLU A 1 473 ? -43.424 -20.091 34.234 1.00 18.77 ? 499 GLU A CD 1 ATOM 3655 O OE1 . GLU A 1 473 ? -42.732 -20.682 35.108 1.00 19.27 ? 499 GLU A OE1 1 ATOM 3656 O OE2 . GLU A 1 473 ? -43.554 -20.547 33.078 1.00 19.83 ? 499 GLU A OE2 1 ATOM 3657 N N . GLN A 1 474 ? -42.145 -15.417 33.605 1.00 15.14 ? 500 GLN A N 1 ATOM 3658 C CA . GLN A 1 474 ? -42.160 -14.596 32.405 1.00 14.79 ? 500 GLN A CA 1 ATOM 3659 C C . GLN A 1 474 ? -40.842 -14.699 31.628 1.00 14.39 ? 500 GLN A C 1 ATOM 3660 O O . GLN A 1 474 ? -40.851 -14.798 30.408 1.00 13.77 ? 500 GLN A O 1 ATOM 3661 C CB . GLN A 1 474 ? -42.492 -13.151 32.760 1.00 14.94 ? 500 GLN A CB 1 ATOM 3662 C CG . GLN A 1 474 ? -43.965 -12.956 33.089 1.00 15.11 ? 500 GLN A CG 1 ATOM 3663 C CD . GLN A 1 474 ? -44.268 -11.598 33.688 1.00 15.33 ? 500 GLN A CD 1 ATOM 3664 O OE1 . GLN A 1 474 ? -43.408 -10.973 34.299 1.00 15.36 ? 500 GLN A OE1 1 ATOM 3665 N NE2 . GLN A 1 474 ? -45.504 -11.142 33.528 1.00 15.39 ? 500 GLN A NE2 1 ATOM 3666 N N . PHE A 1 475 ? -39.718 -14.694 32.336 1.00 14.39 ? 501 PHE A N 1 ATOM 3667 C CA . PHE A 1 475 ? -38.415 -14.893 31.698 1.00 14.68 ? 501 PHE A CA 1 ATOM 3668 C C . PHE A 1 475 ? -38.317 -16.236 30.962 1.00 14.74 ? 501 PHE A C 1 ATOM 3669 O O . PHE A 1 475 ? -37.785 -16.296 29.863 1.00 14.38 ? 501 PHE A O 1 ATOM 3670 C CB . PHE A 1 475 ? -37.278 -14.771 32.718 1.00 14.63 ? 501 PHE A CB 1 ATOM 3671 C CG . PHE A 1 475 ? -36.889 -13.355 33.021 1.00 14.57 ? 501 PHE A CG 1 ATOM 3672 C CD1 . PHE A 1 475 ? -36.424 -12.524 32.011 1.00 14.59 ? 501 PHE A CD1 1 ATOM 3673 C CD2 . PHE A 1 475 ? -36.970 -12.854 34.314 1.00 14.46 ? 501 PHE A CD2 1 ATOM 3674 C CE1 . PHE A 1 475 ? -36.061 -11.216 32.284 1.00 14.59 ? 501 PHE A CE1 1 ATOM 3675 C CE2 . PHE A 1 475 ? -36.603 -11.548 34.590 1.00 14.50 ? 501 PHE A CE2 1 ATOM 3676 C CZ . PHE A 1 475 ? -36.148 -10.730 33.575 1.00 14.43 ? 501 PHE A CZ 1 ATOM 3677 N N . ARG A 1 476 ? -38.837 -17.298 31.569 1.00 15.19 ? 502 ARG A N 1 ATOM 3678 C CA . ARG A 1 476 ? -38.844 -18.619 30.937 1.00 15.88 ? 502 ARG A CA 1 ATOM 3679 C C . ARG A 1 476 ? -39.600 -18.599 29.606 1.00 16.59 ? 502 ARG A C 1 ATOM 3680 O O . ARG A 1 476 ? -39.108 -19.122 28.612 1.00 16.67 ? 502 ARG A O 1 ATOM 3681 C CB . ARG A 1 476 ? -39.442 -19.684 31.869 1.00 15.68 ? 502 ARG A CB 1 ATOM 3682 C CG . ARG A 1 476 ? -38.594 -19.994 33.089 1.00 15.52 ? 502 ARG A CG 1 ATOM 3683 C CD . ARG A 1 476 ? -39.286 -20.957 34.047 1.00 15.55 ? 502 ARG A CD 1 ATOM 3684 N NE . ARG A 1 476 ? -38.641 -20.925 35.361 1.00 15.64 ? 502 ARG A NE 1 ATOM 3685 C CZ . ARG A 1 476 ? -39.204 -20.532 36.504 1.00 15.50 ? 502 ARG A CZ 1 ATOM 3686 N NH1 . ARG A 1 476 ? -40.478 -20.156 36.558 1.00 15.51 ? 502 ARG A NH1 1 ATOM 3687 N NH2 . ARG A 1 476 ? -38.479 -20.531 37.618 1.00 15.31 ? 502 ARG A NH2 1 ATOM 3688 N N . ARG A 1 477 ? -40.778 -17.981 29.582 1.00 17.69 ? 503 ARG A N 1 ATOM 3689 C CA . ARG A 1 477 ? -41.549 -17.867 28.334 1.00 18.52 ? 503 ARG A CA 1 ATOM 3690 C C . ARG A 1 477 ? -40.764 -17.081 27.291 1.00 17.64 ? 503 ARG A C 1 ATOM 3691 O O . ARG A 1 477 ? -40.701 -17.473 26.128 1.00 17.14 ? 503 ARG A O 1 ATOM 3692 C CB . ARG A 1 477 ? -42.893 -17.176 28.558 1.00 20.22 ? 503 ARG A CB 1 ATOM 3693 C CG . ARG A 1 477 ? -43.654 -17.668 29.774 1.00 22.56 ? 503 ARG A CG 1 ATOM 3694 C CD . ARG A 1 477 ? -45.154 -17.579 29.578 1.00 25.05 ? 503 ARG A CD 1 ATOM 3695 N NE . ARG A 1 477 ? -45.861 -18.169 30.714 1.00 27.71 ? 503 ARG A NE 1 ATOM 3696 C CZ . ARG A 1 477 ? -47.080 -18.704 30.657 1.00 29.41 ? 503 ARG A CZ 1 ATOM 3697 N NH1 . ARG A 1 477 ? -47.757 -18.737 29.512 1.00 30.32 ? 503 ARG A NH1 1 ATOM 3698 N NH2 . ARG A 1 477 ? -47.628 -19.211 31.757 1.00 30.15 ? 503 ARG A NH2 1 ATOM 3699 N N . MET A 1 478 ? -40.169 -15.970 27.716 1.00 16.85 ? 504 MET A N 1 ATOM 3700 C CA . MET A 1 478 ? -39.358 -15.156 26.820 1.00 16.71 ? 504 MET A CA 1 ATOM 3701 C C . MET A 1 478 ? -38.165 -15.943 26.272 1.00 15.70 ? 504 MET A C 1 ATOM 3702 O O . MET A 1 478 ? -37.881 -15.889 25.074 1.00 15.22 ? 504 MET A O 1 ATOM 3703 C CB . MET A 1 478 ? -38.885 -13.880 27.521 1.00 17.38 ? 504 MET A CB 1 ATOM 3704 C CG . MET A 1 478 ? -39.992 -12.852 27.703 1.00 18.11 ? 504 MET A CG 1 ATOM 3705 S SD . MET A 1 478 ? -39.397 -11.309 28.411 1.00 19.42 ? 504 MET A SD 1 ATOM 3706 C CE . MET A 1 478 ? -39.718 -11.634 30.133 1.00 18.80 ? 504 MET A CE 1 ATOM 3707 N N . ARG A 1 479 ? -37.482 -16.681 27.142 1.00 14.88 ? 505 ARG A N 1 ATOM 3708 C CA . ARG A 1 479 ? -36.308 -17.447 26.718 1.00 14.62 ? 505 ARG A CA 1 ATOM 3709 C C . ARG A 1 479 ? -36.645 -18.625 25.809 1.00 14.15 ? 505 ARG A C 1 ATOM 3710 O O . ARG A 1 479 ? -35.798 -19.060 25.032 1.00 13.83 ? 505 ARG A O 1 ATOM 3711 C CB . ARG A 1 479 ? -35.483 -17.905 27.922 1.00 14.66 ? 505 ARG A CB 1 ATOM 3712 C CG . ARG A 1 479 ? -34.740 -16.751 28.576 1.00 14.66 ? 505 ARG A CG 1 ATOM 3713 C CD . ARG A 1 479 ? -33.694 -17.231 29.553 1.00 14.60 ? 505 ARG A CD 1 ATOM 3714 N NE . ARG A 1 479 ? -32.859 -16.120 29.995 1.00 14.58 ? 505 ARG A NE 1 ATOM 3715 C CZ . ARG A 1 479 ? -32.964 -15.475 31.156 1.00 14.55 ? 505 ARG A CZ 1 ATOM 3716 N NH1 . ARG A 1 479 ? -33.883 -15.807 32.062 1.00 14.55 ? 505 ARG A NH1 1 ATOM 3717 N NH2 . ARG A 1 479 ? -32.124 -14.481 31.412 1.00 14.72 ? 505 ARG A NH2 1 ATOM 3718 N N . ALA A 1 480 ? -37.884 -19.109 25.883 1.00 14.05 ? 506 ALA A N 1 ATOM 3719 C CA . ALA A 1 480 ? -38.351 -20.205 25.027 1.00 14.29 ? 506 ALA A CA 1 ATOM 3720 C C . ALA A 1 480 ? -38.453 -19.825 23.543 1.00 14.31 ? 506 ALA A C 1 ATOM 3721 O O . ALA A 1 480 ? -38.603 -20.703 22.692 1.00 14.20 ? 506 ALA A O 1 ATOM 3722 C CB . ALA A 1 480 ? -39.698 -20.724 25.523 1.00 14.36 ? 506 ALA A CB 1 ATOM 3723 N N . ALA A 1 481 ? -38.380 -18.532 23.237 1.00 14.34 ? 507 ALA A N 1 ATOM 3724 C CA . ALA A 1 481 ? -38.426 -18.052 21.854 1.00 14.62 ? 507 ALA A CA 1 ATOM 3725 C C . ALA A 1 481 ? -37.050 -17.711 21.277 1.00 14.77 ? 507 ALA A C 1 ATOM 3726 O O . ALA A 1 481 ? -36.971 -17.188 20.168 1.00 15.25 ? 507 ALA A O 1 ATOM 3727 C CB . ALA A 1 481 ? -39.345 -16.839 21.757 1.00 14.55 ? 507 ALA A CB 1 ATOM 3728 N N . GLU A 1 482 ? -35.974 -18.005 22.009 1.00 15.17 ? 508 GLU A N 1 ATOM 3729 C CA . GLU A 1 482 ? -34.610 -17.608 21.594 1.00 15.21 ? 508 GLU A CA 1 ATOM 3730 C C . GLU A 1 482 ? -34.095 -18.434 20.410 1.00 15.26 ? 508 GLU A C 1 ATOM 3731 O O . GLU A 1 482 ? -33.518 -17.899 19.462 1.00 15.40 ? 508 GLU A O 1 ATOM 3732 C CB . GLU A 1 482 ? -33.623 -17.732 22.768 1.00 15.28 ? 508 GLU A CB 1 ATOM 3733 C CG . GLU A 1 482 ? -33.792 -16.681 23.858 1.00 15.48 ? 508 GLU A CG 1 ATOM 3734 C CD . GLU A 1 482 ? -32.787 -16.829 24.994 1.00 15.72 ? 508 GLU A CD 1 ATOM 3735 O OE1 . GLU A 1 482 ? -32.340 -17.965 25.263 1.00 15.79 ? 508 GLU A OE1 1 ATOM 3736 O OE2 . GLU A 1 482 ? -32.439 -15.804 25.627 1.00 15.75 ? 508 GLU A OE2 1 ATOM 3737 N N . ASP A 1 483 ? -34.305 -19.743 20.476 1.00 15.08 ? 509 ASP A N 1 ATOM 3738 C CA . ASP A 1 483 ? -33.759 -20.657 19.484 1.00 14.91 ? 509 ASP A CA 1 ATOM 3739 C C . ASP A 1 483 ? -34.652 -20.764 18.251 1.00 14.66 ? 509 ASP A C 1 ATOM 3740 O O . ASP A 1 483 ? -35.862 -20.531 18.328 1.00 14.45 ? 509 ASP A O 1 ATOM 3741 C CB . ASP A 1 483 ? -33.548 -22.039 20.109 1.00 14.92 ? 509 ASP A CB 1 ATOM 3742 C CG . ASP A 1 483 ? -32.468 -22.027 21.185 1.00 15.33 ? 509 ASP A CG 1 ATOM 3743 O OD1 . ASP A 1 483 ? -31.284 -21.822 20.830 1.00 15.24 ? 509 ASP A OD1 1 ATOM 3744 O OD2 . ASP A 1 483 ? -32.794 -22.225 22.377 1.00 15.21 ? 509 ASP A OD2 1 ATOM 3745 N N . PRO A 1 484 ? -34.051 -21.119 17.102 1.00 14.54 ? 510 PRO A N 1 ATOM 3746 C CA . PRO A 1 484 ? -34.860 -21.345 15.909 1.00 14.51 ? 510 PRO A CA 1 ATOM 3747 C C . PRO A 1 484 ? -35.673 -22.625 16.028 1.00 14.39 ? 510 PRO A C 1 ATOM 3748 O O . PRO A 1 484 ? -35.280 -23.538 16.745 1.00 14.26 ? 510 PRO A O 1 ATOM 3749 C CB . PRO A 1 484 ? -33.822 -21.470 14.788 1.00 14.35 ? 510 PRO A CB 1 ATOM 3750 C CG . PRO A 1 484 ? -32.562 -21.884 15.466 1.00 14.59 ? 510 PRO A CG 1 ATOM 3751 C CD . PRO A 1 484 ? -32.612 -21.344 16.862 1.00 14.35 ? 510 PRO A CD 1 ATOM 3752 N N . VAL A 1 485 ? -36.797 -22.683 15.326 1.00 14.42 ? 511 VAL A N 1 ATOM 3753 C CA . VAL A 1 485 ? -37.556 -23.919 15.220 1.00 14.92 ? 511 VAL A CA 1 ATOM 3754 C C . VAL A 1 485 ? -36.723 -24.924 14.418 1.00 14.83 ? 511 VAL A C 1 ATOM 3755 O O . VAL A 1 485 ? -36.390 -24.672 13.264 1.00 14.97 ? 511 VAL A O 1 ATOM 3756 C CB . VAL A 1 485 ? -38.935 -23.685 14.558 1.00 15.10 ? 511 VAL A CB 1 ATOM 3757 C CG1 . VAL A 1 485 ? -39.675 -25.000 14.346 1.00 15.26 ? 511 VAL A CG1 1 ATOM 3758 C CG2 . VAL A 1 485 ? -39.773 -22.750 15.420 1.00 15.17 ? 511 VAL A CG2 1 ATOM 3759 N N . ALA A 1 486 ? -36.367 -26.041 15.052 1.00 14.90 ? 512 ALA A N 1 ATOM 3760 C CA . ALA A 1 486 ? -35.541 -27.075 14.428 1.00 14.82 ? 512 ALA A CA 1 ATOM 3761 C C . ALA A 1 486 ? -36.359 -28.338 14.178 1.00 14.91 ? 512 ALA A C 1 ATOM 3762 O O . ALA A 1 486 ? -37.098 -28.794 15.055 1.00 15.23 ? 512 ALA A O 1 ATOM 3763 C CB . ALA A 1 486 ? -34.342 -27.398 15.306 1.00 14.71 ? 512 ALA A CB 1 ATOM 3764 N N . ALA A 1 487 ? -36.221 -28.895 12.980 1.00 14.70 ? 513 ALA A N 1 ATOM 3765 C CA . ALA A 1 487 ? -36.877 -30.145 12.618 1.00 14.58 ? 513 ALA A CA 1 ATOM 3766 C C . ALA A 1 487 ? -35.882 -31.296 12.776 1.00 14.73 ? 513 ALA A C 1 ATOM 3767 O O . ALA A 1 487 ? -34.704 -31.157 12.433 1.00 14.90 ? 513 ALA A O 1 ATOM 3768 C CB . ALA A 1 487 ? -37.391 -30.067 11.191 1.00 14.49 ? 513 ALA A CB 1 ATOM 3769 N N . ALA A 1 488 ? -36.352 -32.424 13.303 1.00 14.57 ? 514 ALA A N 1 ATOM 3770 C CA . ALA A 1 488 ? -35.482 -33.567 13.575 1.00 14.84 ? 514 ALA A CA 1 ATOM 3771 C C . ALA A 1 488 ? -34.799 -34.029 12.292 1.00 15.05 ? 514 ALA A C 1 ATOM 3772 O O . ALA A 1 488 ? -35.394 -33.950 11.221 1.00 15.31 ? 514 ALA A O 1 ATOM 3773 C CB . ALA A 1 488 ? -36.276 -34.711 14.191 1.00 14.80 ? 514 ALA A CB 1 ATOM 3774 N N . PRO A 1 489 ? -33.546 -34.513 12.391 1.00 15.30 ? 515 PRO A N 1 ATOM 3775 C CA . PRO A 1 489 ? -32.834 -34.941 11.181 1.00 15.38 ? 515 PRO A CA 1 ATOM 3776 C C . PRO A 1 489 ? -33.629 -35.968 10.360 1.00 15.47 ? 515 PRO A C 1 ATOM 3777 O O . PRO A 1 489 ? -34.232 -36.881 10.929 1.00 15.34 ? 515 PRO A O 1 ATOM 3778 C CB . PRO A 1 489 ? -31.542 -35.565 11.722 1.00 15.23 ? 515 PRO A CB 1 ATOM 3779 C CG . PRO A 1 489 ? -31.362 -34.976 13.072 1.00 15.25 ? 515 PRO A CG 1 ATOM 3780 C CD . PRO A 1 489 ? -32.731 -34.688 13.607 1.00 15.17 ? 515 PRO A CD 1 ATOM 3781 N N . ARG A 1 490 ? -33.634 -35.787 9.039 1.00 15.42 ? 516 ARG A N 1 ATOM 3782 C CA . ARG A 1 490 ? -34.299 -36.700 8.114 1.00 15.52 ? 516 ARG A CA 1 ATOM 3783 C C . ARG A 1 490 ? -33.290 -37.217 7.106 1.00 15.00 ? 516 ARG A C 1 ATOM 3784 O O . ARG A 1 490 ? -32.427 -36.461 6.669 1.00 14.79 ? 516 ARG A O 1 ATOM 3785 C CB . ARG A 1 490 ? -35.418 -35.974 7.378 1.00 16.03 ? 516 ARG A CB 1 ATOM 3786 C CG . ARG A 1 490 ? -36.555 -35.570 8.292 1.00 16.71 ? 516 ARG A CG 1 ATOM 3787 C CD . ARG A 1 490 ? -37.667 -34.877 7.534 1.00 17.43 ? 516 ARG A CD 1 ATOM 3788 N NE . ARG A 1 490 ? -38.854 -34.757 8.370 1.00 18.40 ? 516 ARG A NE 1 ATOM 3789 C CZ . ARG A 1 490 ? -40.020 -34.248 7.973 1.00 19.59 ? 516 ARG A CZ 1 ATOM 3790 N NH1 . ARG A 1 490 ? -40.174 -33.782 6.736 1.00 19.84 ? 516 ARG A NH1 1 ATOM 3791 N NH2 . ARG A 1 490 ? -41.038 -34.203 8.824 1.00 19.77 ? 516 ARG A NH2 1 ATOM 3792 N N . PRO A 1 491 ? -33.391 -38.506 6.732 1.00 14.42 ? 517 PRO A N 1 ATOM 3793 C CA . PRO A 1 491 ? -32.443 -39.039 5.762 1.00 14.23 ? 517 PRO A CA 1 ATOM 3794 C C . PRO A 1 491 ? -32.644 -38.414 4.380 1.00 14.17 ? 517 PRO A C 1 ATOM 3795 O O . PRO A 1 491 ? -33.784 -38.224 3.934 1.00 13.91 ? 517 PRO A O 1 ATOM 3796 C CB . PRO A 1 491 ? -32.744 -40.543 5.759 1.00 14.18 ? 517 PRO A CB 1 ATOM 3797 C CG . PRO A 1 491 ? -34.162 -40.648 6.194 1.00 14.27 ? 517 PRO A CG 1 ATOM 3798 C CD . PRO A 1 491 ? -34.363 -39.523 7.171 1.00 14.41 ? 517 PRO A CD 1 ATOM 3799 N N . LEU A 1 492 ? -31.539 -38.071 3.732 1.00 13.94 ? 518 LEU A N 1 ATOM 3800 C CA . LEU A 1 492 ? -31.580 -37.415 2.437 1.00 14.10 ? 518 LEU A CA 1 ATOM 3801 C C . LEU A 1 492 ? -31.952 -38.429 1.353 1.00 14.54 ? 518 LEU A C 1 ATOM 3802 O O . LEU A 1 492 ? -31.453 -39.559 1.374 1.00 14.42 ? 518 LEU A O 1 ATOM 3803 C CB . LEU A 1 492 ? -30.215 -36.802 2.116 1.00 13.84 ? 518 LEU A CB 1 ATOM 3804 C CG . LEU A 1 492 ? -30.171 -35.845 0.926 1.00 13.78 ? 518 LEU A CG 1 ATOM 3805 C CD1 . LEU A 1 492 ? -30.835 -34.513 1.274 1.00 13.66 ? 518 LEU A CD1 1 ATOM 3806 C CD2 . LEU A 1 492 ? -28.736 -35.627 0.477 1.00 13.70 ? 518 LEU A CD2 1 ATOM 3807 N N . PRO A 1 493 ? -32.821 -38.033 0.400 1.00 14.90 ? 519 PRO A N 1 ATOM 3808 C CA . PRO A 1 493 ? -33.095 -38.896 -0.759 1.00 15.33 ? 519 PRO A CA 1 ATOM 3809 C C . PRO A 1 493 ? -31.818 -39.282 -1.508 1.00 16.08 ? 519 PRO A C 1 ATOM 3810 O O . PRO A 1 493 ? -30.873 -38.490 -1.577 1.00 16.22 ? 519 PRO A O 1 ATOM 3811 C CB . PRO A 1 493 ? -33.977 -38.015 -1.662 1.00 15.13 ? 519 PRO A CB 1 ATOM 3812 C CG . PRO A 1 493 ? -34.592 -37.011 -0.750 1.00 15.07 ? 519 PRO A CG 1 ATOM 3813 C CD . PRO A 1 493 ? -33.577 -36.768 0.334 1.00 14.96 ? 519 PRO A CD 1 ATOM 3814 N N . ALA A 1 494 ? -31.797 -40.488 -2.063 1.00 16.94 ? 520 ALA A N 1 ATOM 3815 C CA . ALA A 1 494 ? -30.683 -40.925 -2.899 1.00 17.54 ? 520 ALA A CA 1 ATOM 3816 C C . ALA A 1 494 ? -30.641 -40.088 -4.166 1.00 17.54 ? 520 ALA A C 1 ATOM 3817 O O . ALA A 1 494 ? -31.658 -39.545 -4.588 1.00 18.35 ? 520 ALA A O 1 ATOM 3818 C CB . ALA A 1 494 ? -30.826 -42.395 -3.248 1.00 17.81 ? 520 ALA A CB 1 ATOM 3819 N N . GLY A 1 495 ? -29.460 -39.976 -4.760 1.00 17.58 ? 521 GLY A N 1 ATOM 3820 C CA . GLY A 1 495 ? -29.263 -39.121 -5.927 1.00 17.95 ? 521 GLY A CA 1 ATOM 3821 C C . GLY A 1 495 ? -28.836 -37.707 -5.562 1.00 18.17 ? 521 GLY A C 1 ATOM 3822 O O . GLY A 1 495 ? -28.570 -36.893 -6.443 1.00 18.15 ? 521 GLY A O 1 ATOM 3823 N N . GLY A 1 496 ? -28.778 -37.410 -4.265 1.00 18.31 ? 522 GLY A N 1 ATOM 3824 C CA . GLY A 1 496 ? -28.259 -36.134 -3.787 1.00 18.47 ? 522 GLY A CA 1 ATOM 3825 C C . GLY A 1 496 ? -29.126 -34.928 -4.102 1.00 18.42 ? 522 GLY A C 1 ATOM 3826 O O . GLY A 1 496 ? -28.605 -33.833 -4.339 1.00 18.82 ? 522 GLY A O 1 ATOM 3827 N N . ARG A 1 497 ? -30.441 -35.126 -4.076 1.00 17.82 ? 523 ARG A N 1 ATOM 3828 C CA . ARG A 1 497 ? -31.403 -34.097 -4.448 1.00 17.77 ? 523 ARG A CA 1 ATOM 3829 C C . ARG A 1 497 ? -32.485 -33.975 -3.398 1.00 17.72 ? 523 ARG A C 1 ATOM 3830 O O . ARG A 1 497 ? -32.873 -34.967 -2.775 1.00 17.60 ? 523 ARG A O 1 ATOM 3831 C CB . ARG A 1 497 ? -32.067 -34.429 -5.781 1.00 17.77 ? 523 ARG A CB 1 ATOM 3832 C CG . ARG A 1 497 ? -31.095 -34.575 -6.933 1.00 18.00 ? 523 ARG A CG 1 ATOM 3833 C CD . ARG A 1 497 ? -31.681 -35.414 -8.050 1.00 18.09 ? 523 ARG A CD 1 ATOM 3834 N NE . ARG A 1 497 ? -32.658 -34.679 -8.846 1.00 18.27 ? 523 ARG A NE 1 ATOM 3835 C CZ . ARG A 1 497 ? -32.356 -33.867 -9.858 1.00 18.25 ? 523 ARG A CZ 1 ATOM 3836 N NH1 . ARG A 1 497 ? -31.093 -33.646 -10.209 1.00 18.38 ? 523 ARG A NH1 1 ATOM 3837 N NH2 . ARG A 1 497 ? -33.331 -33.267 -10.523 1.00 18.09 ? 523 ARG A NH2 1 ATOM 3838 N N . LEU A 1 498 ? -32.988 -32.755 -3.234 1.00 17.35 ? 524 LEU A N 1 ATOM 3839 C CA . LEU A 1 498 ? -34.007 -32.462 -2.244 1.00 17.37 ? 524 LEU A CA 1 ATOM 3840 C C . LEU A 1 498 ? -34.764 -31.206 -2.654 1.00 17.60 ? 524 LEU A C 1 ATOM 3841 O O . LEU A 1 498 ? -34.148 -30.198 -3.019 1.00 16.69 ? 524 LEU A O 1 ATOM 3842 C CB . LEU A 1 498 ? -33.359 -32.265 -0.869 1.00 17.23 ? 524 LEU A CB 1 ATOM 3843 C CG . LEU A 1 498 ? -34.268 -31.831 0.283 1.00 17.16 ? 524 LEU A CG 1 ATOM 3844 C CD1 . LEU A 1 498 ? -35.263 -32.928 0.620 1.00 17.17 ? 524 LEU A CD1 1 ATOM 3845 C CD2 . LEU A 1 498 ? -33.451 -31.461 1.508 1.00 17.09 ? 524 LEU A CD2 1 ATOM 3846 N N . THR A 1 499 ? -36.094 -31.279 -2.598 1.00 17.98 ? 525 THR A N 1 ATOM 3847 C CA . THR A 1 499 ? -36.947 -30.123 -2.858 1.00 18.64 ? 525 THR A CA 1 ATOM 3848 C C . THR A 1 499 ? -37.824 -29.820 -1.648 1.00 18.64 ? 525 THR A C 1 ATOM 3849 O O . THR A 1 499 ? -38.567 -30.686 -1.186 1.00 18.89 ? 525 THR A O 1 ATOM 3850 C CB . THR A 1 499 ? -37.837 -30.343 -4.098 1.00 19.09 ? 525 THR A CB 1 ATOM 3851 O OG1 . THR A 1 499 ? -37.007 -30.626 -5.231 1.00 19.67 ? 525 THR A OG1 1 ATOM 3852 C CG2 . THR A 1 499 ? -38.658 -29.100 -4.400 1.00 19.23 ? 525 THR A CG2 1 ATOM 3853 N N . LEU A 1 500 ? -37.716 -28.595 -1.138 1.00 18.88 ? 526 LEU A N 1 ATOM 3854 C CA . LEU A 1 500 ? -38.535 -28.120 -0.022 1.00 18.93 ? 526 LEU A CA 1 ATOM 3855 C C . LEU A 1 500 ? -39.328 -26.916 -0.488 1.00 19.87 ? 526 LEU A C 1 ATOM 3856 O O . LEU A 1 500 ? -38.851 -26.141 -1.310 1.00 19.52 ? 526 LEU A O 1 ATOM 3857 C CB . LEU A 1 500 ? -37.665 -27.726 1.173 1.00 18.74 ? 526 LEU A CB 1 ATOM 3858 C CG . LEU A 1 500 ? -36.686 -28.771 1.719 1.00 18.42 ? 526 LEU A CG 1 ATOM 3859 C CD1 . LEU A 1 500 ? -35.917 -28.199 2.899 1.00 18.16 ? 526 LEU A CD1 1 ATOM 3860 C CD2 . LEU A 1 500 ? -37.411 -30.047 2.120 1.00 18.11 ? 526 LEU A CD2 1 ATOM 3861 N N . ARG A 1 501 ? -40.537 -26.761 0.041 1.00 21.47 ? 527 ARG A N 1 ATOM 3862 C CA . ARG A 1 501 ? -41.425 -25.681 -0.373 1.00 22.62 ? 527 ARG A CA 1 ATOM 3863 C C . ARG A 1 501 ? -41.959 -24.928 0.840 1.00 22.02 ? 527 ARG A C 1 ATOM 3864 O O . ARG A 1 501 ? -43.158 -24.939 1.092 1.00 22.05 ? 527 ARG A O 1 ATOM 3865 C CB . ARG A 1 501 ? -42.589 -26.239 -1.191 1.00 24.33 ? 527 ARG A CB 1 ATOM 3866 C CG . ARG A 1 501 ? -42.173 -27.101 -2.372 1.00 25.88 ? 527 ARG A CG 1 ATOM 3867 C CD . ARG A 1 501 ? -43.388 -27.719 -3.046 1.00 27.19 ? 527 ARG A CD 1 ATOM 3868 N NE . ARG A 1 501 ? -43.969 -26.815 -4.037 1.00 28.84 ? 527 ARG A NE 1 ATOM 3869 C CZ . ARG A 1 501 ? -45.233 -26.848 -4.451 1.00 29.73 ? 527 ARG A CZ 1 ATOM 3870 N NH1 . ARG A 1 501 ? -46.091 -27.732 -3.951 1.00 31.27 ? 527 ARG A NH1 1 ATOM 3871 N NH2 . ARG A 1 501 ? -45.647 -25.980 -5.368 1.00 30.51 ? 527 ARG A NH2 1 ATOM 3872 N N . PRO A 1 502 ? -41.065 -24.259 1.590 1.00 21.96 ? 528 PRO A N 1 ATOM 3873 C CA . PRO A 1 502 ? -41.479 -23.579 2.817 1.00 21.70 ? 528 PRO A CA 1 ATOM 3874 C C . PRO A 1 502 ? -42.239 -22.280 2.571 1.00 21.80 ? 528 PRO A C 1 ATOM 3875 O O . PRO A 1 502 ? -42.008 -21.590 1.574 1.00 21.30 ? 528 PRO A O 1 ATOM 3876 C CB . PRO A 1 502 ? -40.149 -23.277 3.504 1.00 21.58 ? 528 PRO A CB 1 ATOM 3877 C CG . PRO A 1 502 ? -39.199 -23.093 2.373 1.00 21.52 ? 528 PRO A CG 1 ATOM 3878 C CD . PRO A 1 502 ? -39.618 -24.105 1.346 1.00 21.51 ? 528 PRO A CD 1 ATOM 3879 N N . ALA A 1 503 ? -43.143 -21.966 3.490 1.00 22.21 ? 529 ALA A N 1 ATOM 3880 C CA . ALA A 1 503 ? -43.838 -20.688 3.492 1.00 22.36 ? 529 ALA A CA 1 ATOM 3881 C C . ALA A 1 503 ? -43.087 -19.772 4.449 1.00 22.06 ? 529 ALA A C 1 ATOM 3882 O O . ALA A 1 503 ? -43.303 -19.805 5.657 1.00 22.48 ? 529 ALA A O 1 ATOM 3883 C CB . ALA A 1 503 ? -45.283 -20.865 3.927 1.00 22.32 ? 529 ALA A CB 1 ATOM 3884 N N . LEU A 1 504 ? -42.177 -18.979 3.900 1.00 21.91 ? 530 LEU A N 1 ATOM 3885 C CA . LEU A 1 504 ? -41.359 -18.091 4.705 1.00 21.77 ? 530 LEU A CA 1 ATOM 3886 C C . LEU A 1 504 ? -42.123 -16.810 5.024 1.00 22.18 ? 530 LEU A C 1 ATOM 3887 O O . LEU A 1 504 ? -42.980 -16.376 4.252 1.00 22.09 ? 530 LEU A O 1 ATOM 3888 C CB . LEU A 1 504 ? -40.056 -17.769 3.978 1.00 21.59 ? 530 LEU A CB 1 ATOM 3889 C CG . LEU A 1 504 ? -39.163 -18.954 3.609 1.00 21.54 ? 530 LEU A CG 1 ATOM 3890 C CD1 . LEU A 1 504 ? -37.863 -18.452 3.008 1.00 21.56 ? 530 LEU A CD1 1 ATOM 3891 C CD2 . LEU A 1 504 ? -38.875 -19.842 4.807 1.00 21.65 ? 530 LEU A CD2 1 ATOM 3892 N N . ARG A 1 505 ? -41.824 -16.229 6.181 1.00 22.62 ? 531 ARG A N 1 ATOM 3893 C CA . ARG A 1 505 ? -42.384 -14.939 6.561 1.00 22.86 ? 531 ARG A CA 1 ATOM 3894 C C . ARG A 1 505 ? -41.372 -13.847 6.260 1.00 21.26 ? 531 ARG A C 1 ATOM 3895 O O . ARG A 1 505 ? -40.227 -14.126 5.903 1.00 20.61 ? 531 ARG A O 1 ATOM 3896 C CB . ARG A 1 505 ? -42.769 -14.917 8.045 1.00 24.23 ? 531 ARG A CB 1 ATOM 3897 C CG . ARG A 1 505 ? -43.636 -16.082 8.497 1.00 25.72 ? 531 ARG A CG 1 ATOM 3898 C CD . ARG A 1 505 ? -44.942 -16.203 7.723 1.00 27.76 ? 531 ARG A CD 1 ATOM 3899 N NE . ARG A 1 505 ? -45.988 -15.337 8.250 1.00 30.39 ? 531 ARG A NE 1 ATOM 3900 C CZ . ARG A 1 505 ? -47.251 -15.324 7.817 1.00 32.96 ? 531 ARG A CZ 1 ATOM 3901 N NH1 . ARG A 1 505 ? -47.641 -16.128 6.827 1.00 33.63 ? 531 ARG A NH1 1 ATOM 3902 N NH2 . ARG A 1 505 ? -48.129 -14.495 8.373 1.00 33.58 ? 531 ARG A NH2 1 ATOM 3903 N N . LEU A 1 506 ? -41.810 -12.603 6.405 1.00 19.81 ? 532 LEU A N 1 ATOM 3904 C CA . LEU A 1 506 ? -40.975 -11.451 6.126 1.00 18.73 ? 532 LEU A CA 1 ATOM 3905 C C . LEU A 1 506 ? -40.987 -10.524 7.342 1.00 17.58 ? 532 LEU A C 1 ATOM 3906 O O . LEU A 1 506 ? -41.973 -9.823 7.577 1.00 17.63 ? 532 LEU A O 1 ATOM 3907 C CB . LEU A 1 506 ? -41.497 -10.744 4.877 1.00 19.20 ? 532 LEU A CB 1 ATOM 3908 C CG . LEU A 1 506 ? -40.639 -9.660 4.240 1.00 19.63 ? 532 LEU A CG 1 ATOM 3909 C CD1 . LEU A 1 506 ? -39.255 -10.173 3.886 1.00 19.73 ? 532 LEU A CD1 1 ATOM 3910 C CD2 . LEU A 1 506 ? -41.349 -9.141 3.001 1.00 20.08 ? 532 LEU A CD2 1 ATOM 3911 N N . PRO A 1 507 ? -39.893 -10.517 8.129 1.00 16.08 ? 533 PRO A N 1 ATOM 3912 C CA . PRO A 1 507 ? -38.597 -11.199 7.963 1.00 15.52 ? 533 PRO A CA 1 ATOM 3913 C C . PRO A 1 507 ? -38.588 -12.679 8.331 1.00 14.87 ? 533 PRO A C 1 ATOM 3914 O O . PRO A 1 507 ? -39.412 -13.126 9.124 1.00 14.57 ? 533 PRO A O 1 ATOM 3915 C CB . PRO A 1 507 ? -37.708 -10.460 8.960 1.00 15.38 ? 533 PRO A CB 1 ATOM 3916 C CG . PRO A 1 507 ? -38.648 -10.166 10.078 1.00 15.54 ? 533 PRO A CG 1 ATOM 3917 C CD . PRO A 1 507 ? -39.937 -9.772 9.398 1.00 15.71 ? 533 PRO A CD 1 ATOM 3918 N N . SER A 1 508 ? -37.640 -13.423 7.768 1.00 14.64 ? 534 SER A N 1 ATOM 3919 C CA . SER A 1 508 ? -37.337 -14.783 8.234 1.00 14.22 ? 534 SER A CA 1 ATOM 3920 C C . SER A 1 508 ? -35.968 -15.292 7.769 1.00 13.80 ? 534 SER A C 1 ATOM 3921 O O . SER A 1 508 ? -35.400 -14.807 6.778 1.00 13.67 ? 534 SER A O 1 ATOM 3922 C CB . SER A 1 508 ? -38.422 -15.780 7.806 1.00 14.30 ? 534 SER A CB 1 ATOM 3923 O OG . SER A 1 508 ? -38.422 -15.969 6.401 1.00 14.49 ? 534 SER A OG 1 ATOM 3924 N N . LEU A 1 509 ? -35.454 -16.275 8.506 1.00 13.23 ? 535 LEU A N 1 ATOM 3925 C CA . LEU A 1 509 ? -34.233 -16.982 8.154 1.00 12.85 ? 535 LEU A CA 1 ATOM 3926 C C . LEU A 1 509 ? -34.489 -18.485 8.149 1.00 12.92 ? 535 LEU A C 1 ATOM 3927 O O . LEU A 1 509 ? -35.193 -19.008 9.017 1.00 12.62 ? 535 LEU A O 1 ATOM 3928 C CB . LEU A 1 509 ? -33.117 -16.651 9.148 1.00 12.78 ? 535 LEU A CB 1 ATOM 3929 C CG . LEU A 1 509 ? -32.549 -15.232 9.079 1.00 12.72 ? 535 LEU A CG 1 ATOM 3930 C CD1 . LEU A 1 509 ? -31.651 -14.947 10.270 1.00 12.61 ? 535 LEU A CD1 1 ATOM 3931 C CD2 . LEU A 1 509 ? -31.795 -15.014 7.771 1.00 12.76 ? 535 LEU A CD2 1 ATOM 3932 N N . LEU A 1 510 ? -33.921 -19.170 7.158 1.00 12.96 ? 536 LEU A N 1 ATOM 3933 C CA . LEU A 1 510 ? -34.019 -20.625 7.056 1.00 13.07 ? 536 LEU A CA 1 ATOM 3934 C C . LEU A 1 510 ? -32.658 -21.189 6.692 1.00 13.00 ? 536 LEU A C 1 ATOM 3935 O O . LEU A 1 510 ? -32.135 -20.889 5.621 1.00 12.91 ? 536 LEU A O 1 ATOM 3936 C CB . LEU A 1 510 ? -35.032 -21.033 5.986 1.00 13.03 ? 536 LEU A CB 1 ATOM 3937 C CG . LEU A 1 510 ? -35.119 -22.540 5.685 1.00 13.33 ? 536 LEU A CG 1 ATOM 3938 C CD1 . LEU A 1 510 ? -35.892 -23.283 6.765 1.00 13.25 ? 536 LEU A CD1 1 ATOM 3939 C CD2 . LEU A 1 510 ? -35.751 -22.787 4.324 1.00 13.43 ? 536 LEU A CD2 1 ATOM 3940 N N . LEU A 1 511 ? -32.092 -22.000 7.580 1.00 13.12 ? 537 LEU A N 1 ATOM 3941 C CA . LEU A 1 511 ? -30.877 -22.735 7.269 1.00 13.44 ? 537 LEU A CA 1 ATOM 3942 C C . LEU A 1 511 ? -31.209 -24.201 7.048 1.00 13.35 ? 537 LEU A C 1 ATOM 3943 O O . LEU A 1 511 ? -31.777 -24.845 7.928 1.00 13.48 ? 537 LEU A O 1 ATOM 3944 C CB . LEU A 1 511 ? -29.845 -22.592 8.386 1.00 13.74 ? 537 LEU A CB 1 ATOM 3945 C CG . LEU A 1 511 ? -28.441 -23.086 7.998 1.00 14.14 ? 537 LEU A CG 1 ATOM 3946 C CD1 . LEU A 1 511 ? -27.370 -22.132 8.491 1.00 14.41 ? 537 LEU A CD1 1 ATOM 3947 C CD2 . LEU A 1 511 ? -28.167 -24.488 8.507 1.00 14.21 ? 537 LEU A CD2 1 ATOM 3948 N N . VAL A 1 512 ? -30.893 -24.712 5.860 1.00 13.38 ? 538 VAL A N 1 ATOM 3949 C CA . VAL A 1 512 ? -30.923 -26.151 5.609 1.00 13.56 ? 538 VAL A CA 1 ATOM 3950 C C . VAL A 1 512 ? -29.499 -26.688 5.764 1.00 13.56 ? 538 VAL A C 1 ATOM 3951 O O . VAL A 1 512 ? -28.576 -26.248 5.073 1.00 13.52 ? 538 VAL A O 1 ATOM 3952 C CB . VAL A 1 512 ? -31.464 -26.500 4.206 1.00 13.72 ? 538 VAL A CB 1 ATOM 3953 C CG1 . VAL A 1 512 ? -31.657 -28.006 4.072 1.00 13.75 ? 538 VAL A CG1 1 ATOM 3954 C CG2 . VAL A 1 512 ? -32.775 -25.768 3.940 1.00 13.79 ? 538 VAL A CG2 1 ATOM 3955 N N . HIS A 1 513 ? -29.332 -27.628 6.687 1.00 13.76 ? 539 HIS A N 1 ATOM 3956 C CA . HIS A 1 513 ? -28.038 -28.230 6.967 1.00 14.10 ? 539 HIS A CA 1 ATOM 3957 C C . HIS A 1 513 ? -28.050 -29.665 6.459 1.00 14.36 ? 539 HIS A C 1 ATOM 3958 O O . HIS A 1 513 ? -28.887 -30.463 6.879 1.00 14.70 ? 539 HIS A O 1 ATOM 3959 C CB . HIS A 1 513 ? -27.774 -28.183 8.478 1.00 14.13 ? 539 HIS A CB 1 ATOM 3960 C CG . HIS A 1 513 ? -26.324 -28.202 8.849 1.00 14.18 ? 539 HIS A CG 1 ATOM 3961 N ND1 . HIS A 1 513 ? -25.882 -28.645 10.076 1.00 14.10 ? 539 HIS A ND1 1 ATOM 3962 C CD2 . HIS A 1 513 ? -25.218 -27.826 8.162 1.00 14.20 ? 539 HIS A CD2 1 ATOM 3963 C CE1 . HIS A 1 513 ? -24.567 -28.544 10.128 1.00 14.17 ? 539 HIS A CE1 1 ATOM 3964 N NE2 . HIS A 1 513 ? -24.139 -28.053 8.979 1.00 14.18 ? 539 HIS A NE2 1 ATOM 3965 N N . VAL A 1 514 ? -27.143 -29.988 5.541 1.00 14.60 ? 540 VAL A N 1 ATOM 3966 C CA . VAL A 1 514 ? -27.053 -31.336 4.981 1.00 14.77 ? 540 VAL A CA 1 ATOM 3967 C C . VAL A 1 514 ? -25.706 -31.908 5.389 1.00 15.14 ? 540 VAL A C 1 ATOM 3968 O O . VAL A 1 514 ? -24.667 -31.340 5.052 1.00 15.13 ? 540 VAL A O 1 ATOM 3969 C CB . VAL A 1 514 ? -27.176 -31.323 3.448 1.00 14.76 ? 540 VAL A CB 1 ATOM 3970 C CG1 . VAL A 1 514 ? -27.261 -32.744 2.909 1.00 14.68 ? 540 VAL A CG1 1 ATOM 3971 C CG2 . VAL A 1 514 ? -28.402 -30.526 3.026 1.00 14.67 ? 540 VAL A CG2 1 ATOM 3972 N N A CYS A 1 515 ? -25.740 -33.028 6.113 0.50 15.31 ? 541 CYS A N 1 ATOM 3973 N N B CYS A 1 515 ? -25.723 -33.029 6.104 0.50 15.27 ? 541 CYS A N 1 ATOM 3974 C CA A CYS A 1 515 ? -24.565 -33.596 6.774 0.50 15.58 ? 541 CYS A CA 1 ATOM 3975 C CA B CYS A 1 515 ? -24.509 -33.563 6.703 0.50 15.53 ? 541 CYS A CA 1 ATOM 3976 C C A CYS A 1 515 ? -24.441 -35.090 6.510 0.50 15.83 ? 541 CYS A C 1 ATOM 3977 C C B CYS A 1 515 ? -24.414 -35.073 6.557 0.50 15.79 ? 541 CYS A C 1 ATOM 3978 O O A CYS A 1 515 ? -25.410 -35.833 6.686 0.50 15.92 ? 541 CYS A O 1 ATOM 3979 O O B CYS A 1 515 ? -25.365 -35.802 6.852 0.50 15.88 ? 541 CYS A O 1 ATOM 3980 C CB A CYS A 1 515 ? -24.672 -33.399 8.290 0.50 15.60 ? 541 CYS A CB 1 ATOM 3981 C CB B CYS A 1 515 ? -24.444 -33.180 8.183 0.50 15.51 ? 541 CYS A CB 1 ATOM 3982 S SG A CYS A 1 515 ? -23.961 -31.879 8.959 0.50 15.68 ? 541 CYS A SG 1 ATOM 3983 S SG B CYS A 1 515 ? -24.406 -31.396 8.477 0.50 15.57 ? 541 CYS A SG 1 ATOM 3984 N N . ALA A 1 516 ? -23.251 -35.522 6.093 1.00 15.94 ? 542 ALA A N 1 ATOM 3985 C CA . ALA A 1 516 ? -22.908 -36.933 6.048 1.00 16.39 ? 542 ALA A CA 1 ATOM 3986 C C . ALA A 1 516 ? -22.400 -37.327 7.438 1.00 17.11 ? 542 ALA A C 1 ATOM 3987 O O . ALA A 1 516 ? -21.938 -36.477 8.196 1.00 16.85 ? 542 ALA A O 1 ATOM 3988 C CB . ALA A 1 516 ? -21.838 -37.185 4.994 1.00 16.47 ? 542 ALA A CB 1 ATOM 3989 N N . ARG A 1 517 ? -22.481 -38.615 7.759 1.00 17.92 ? 543 ARG A N 1 ATOM 3990 C CA . ARG A 1 517 ? -22.150 -39.122 9.092 1.00 18.89 ? 543 ARG A CA 1 ATOM 3991 C C . ARG A 1 517 ? -20.645 -39.299 9.277 1.00 19.25 ? 543 ARG A C 1 ATOM 3992 O O . ARG A 1 517 ? -20.038 -40.116 8.587 1.00 19.24 ? 543 ARG A O 1 ATOM 3993 C CB . ARG A 1 517 ? -22.855 -40.461 9.311 1.00 19.50 ? 543 ARG A CB 1 ATOM 3994 C CG . ARG A 1 517 ? -22.783 -41.021 10.722 1.00 20.32 ? 543 ARG A CG 1 ATOM 3995 C CD . ARG A 1 517 ? -23.668 -42.256 10.802 1.00 21.00 ? 543 ARG A CD 1 ATOM 3996 N NE . ARG A 1 517 ? -23.606 -42.946 12.087 1.00 21.93 ? 543 ARG A NE 1 ATOM 3997 C CZ . ARG A 1 517 ? -22.605 -43.737 12.482 1.00 22.93 ? 543 ARG A CZ 1 ATOM 3998 N NH1 . ARG A 1 517 ? -21.530 -43.931 11.713 1.00 23.59 ? 543 ARG A NH1 1 ATOM 3999 N NH2 . ARG A 1 517 ? -22.667 -44.330 13.669 1.00 22.61 ? 543 ARG A NH2 1 ATOM 4000 N N . PRO A 1 518 ? -20.030 -38.533 10.206 1.00 19.65 ? 544 PRO A N 1 ATOM 4001 C CA . PRO A 1 518 ? -18.620 -38.786 10.528 1.00 20.09 ? 544 PRO A CA 1 ATOM 4002 C C . PRO A 1 518 ? -18.436 -40.149 11.191 1.00 20.66 ? 544 PRO A C 1 ATOM 4003 O O . PRO A 1 518 ? -19.292 -40.576 11.967 1.00 20.56 ? 544 PRO A O 1 ATOM 4004 C CB . PRO A 1 518 ? -18.263 -37.658 11.514 1.00 19.72 ? 544 PRO A CB 1 ATOM 4005 C CG . PRO A 1 518 ? -19.325 -36.630 11.341 1.00 19.59 ? 544 PRO A CG 1 ATOM 4006 C CD . PRO A 1 518 ? -20.561 -37.396 10.977 1.00 19.51 ? 544 PRO A CD 1 ATOM 4007 N N . GLU A 1 519 ? -17.330 -40.820 10.883 1.00 22.13 ? 545 GLU A N 1 ATOM 4008 C CA . GLU A 1 519 ? -17.070 -42.157 11.421 1.00 23.35 ? 545 GLU A CA 1 ATOM 4009 C C . GLU A 1 519 ? -17.088 -42.140 12.950 1.00 23.11 ? 545 GLU A C 1 ATOM 4010 O O . GLU A 1 519 ? -17.746 -42.968 13.571 1.00 23.20 ? 545 GLU A O 1 ATOM 4011 C CB . GLU A 1 519 ? -15.727 -42.686 10.907 1.00 25.12 ? 545 GLU A CB 1 ATOM 4012 C CG . GLU A 1 519 ? -15.449 -44.155 11.206 1.00 26.50 ? 545 GLU A CG 1 ATOM 4013 C CD . GLU A 1 519 ? -14.035 -44.560 10.806 1.00 27.91 ? 545 GLU A CD 1 ATOM 4014 O OE1 . GLU A 1 519 ? -13.246 -44.935 11.702 1.00 29.24 ? 545 GLU A OE1 1 ATOM 4015 O OE2 . GLU A 1 519 ? -13.703 -44.484 9.599 1.00 28.24 ? 545 GLU A OE2 1 ATOM 4016 N N . LYS A 1 520 ? -16.387 -41.183 13.554 1.00 22.80 ? 546 LYS A N 1 ATOM 4017 C CA . LYS A 1 520 ? -16.327 -41.100 15.013 1.00 23.13 ? 546 LYS A CA 1 ATOM 4018 C C . LYS A 1 520 ? -17.324 -40.080 15.560 1.00 21.77 ? 546 LYS A C 1 ATOM 4019 O O . LYS A 1 520 ? -17.708 -39.145 14.849 1.00 21.51 ? 546 LYS A O 1 ATOM 4020 C CB . LYS A 1 520 ? -14.898 -40.791 15.474 1.00 24.66 ? 546 LYS A CB 1 ATOM 4021 C CG . LYS A 1 520 ? -13.935 -41.954 15.245 1.00 26.06 ? 546 LYS A CG 1 ATOM 4022 C CD . LYS A 1 520 ? -12.842 -42.013 16.303 1.00 27.98 ? 546 LYS A CD 1 ATOM 4023 C CE . LYS A 1 520 ? -11.776 -40.945 16.093 1.00 29.17 ? 546 LYS A CE 1 ATOM 4024 N NZ . LYS A 1 520 ? -10.706 -41.422 15.168 1.00 30.29 ? 546 LYS A NZ 1 ATOM 4025 N N . PRO A 1 521 ? -17.757 -40.259 16.824 1.00 20.28 ? 547 PRO A N 1 ATOM 4026 C CA . PRO A 1 521 ? -18.724 -39.327 17.401 1.00 19.65 ? 547 PRO A CA 1 ATOM 4027 C C . PRO A 1 521 ? -18.080 -37.987 17.796 1.00 18.82 ? 547 PRO A C 1 ATOM 4028 O O . PRO A 1 521 ? -16.864 -37.826 17.659 1.00 17.81 ? 547 PRO A O 1 ATOM 4029 C CB . PRO A 1 521 ? -19.271 -40.087 18.619 1.00 19.71 ? 547 PRO A CB 1 ATOM 4030 C CG . PRO A 1 521 ? -18.230 -41.090 18.971 1.00 20.04 ? 547 PRO A CG 1 ATOM 4031 C CD . PRO A 1 521 ? -17.290 -41.253 17.808 1.00 20.40 ? 547 PRO A CD 1 ATOM 4032 N N . PRO A 1 522 ? -18.892 -37.019 18.264 1.00 18.08 ? 548 PRO A N 1 ATOM 4033 C CA . PRO A 1 522 ? -18.377 -35.684 18.598 1.00 17.44 ? 548 PRO A CA 1 ATOM 4034 C C . PRO A 1 522 ? -17.354 -35.667 19.725 1.00 16.79 ? 548 PRO A C 1 ATOM 4035 O O . PRO A 1 522 ? -17.294 -36.588 20.524 1.00 16.65 ? 548 PRO A O 1 ATOM 4036 C CB . PRO A 1 522 ? -19.633 -34.927 19.044 1.00 17.56 ? 548 PRO A CB 1 ATOM 4037 C CG . PRO A 1 522 ? -20.756 -35.631 18.369 1.00 17.75 ? 548 PRO A CG 1 ATOM 4038 C CD . PRO A 1 522 ? -20.361 -37.076 18.377 1.00 17.91 ? 548 PRO A CD 1 ATOM 4039 N N . GLY A 1 523 ? -16.576 -34.594 19.792 1.00 16.49 ? 549 GLY A N 1 ATOM 4040 C CA . GLY A 1 523 ? -15.581 -34.424 20.842 1.00 15.82 ? 549 GLY A CA 1 ATOM 4041 C C . GLY A 1 523 ? -16.187 -33.933 22.144 1.00 15.28 ? 549 GLY A C 1 ATOM 4042 O O . GLY A 1 523 ? -17.414 -33.872 22.294 1.00 15.36 ? 549 GLY A O 1 ATOM 4043 N N . GLN A 1 524 ? -15.312 -33.571 23.076 1.00 14.35 ? 550 GLN A N 1 ATOM 4044 C CA . GLN A 1 524 ? -15.691 -33.240 24.442 1.00 13.87 ? 550 GLN A CA 1 ATOM 4045 C C . GLN A 1 524 ? -15.989 -31.750 24.629 1.00 13.71 ? 550 GLN A C 1 ATOM 4046 O O . GLN A 1 524 ? -15.235 -30.901 24.154 1.00 13.60 ? 550 GLN A O 1 ATOM 4047 C CB . GLN A 1 524 ? -14.545 -33.628 25.384 1.00 13.59 ? 550 GLN A CB 1 ATOM 4048 C CG . GLN A 1 524 ? -14.929 -33.615 26.853 1.00 13.51 ? 550 GLN A CG 1 ATOM 4049 C CD . GLN A 1 524 ? -13.748 -33.784 27.780 1.00 13.46 ? 550 GLN A CD 1 ATOM 4050 O OE1 . GLN A 1 524 ? -12.598 -33.546 27.405 1.00 13.05 ? 550 GLN A OE1 1 ATOM 4051 N NE2 . GLN A 1 524 ? -14.031 -34.187 29.015 1.00 13.62 ? 550 GLN A NE2 1 ATOM 4052 N N . VAL A 1 525 ? -17.081 -31.448 25.329 1.00 13.59 ? 551 VAL A N 1 ATOM 4053 C CA . VAL A 1 525 ? -17.354 -30.091 25.824 1.00 13.78 ? 551 VAL A CA 1 ATOM 4054 C C . VAL A 1 525 ? -16.297 -29.725 26.865 1.00 13.96 ? 551 VAL A C 1 ATOM 4055 O O . VAL A 1 525 ? -16.008 -30.521 27.761 1.00 14.03 ? 551 VAL A O 1 ATOM 4056 C CB . VAL A 1 525 ? -18.745 -29.992 26.506 1.00 13.53 ? 551 VAL A CB 1 ATOM 4057 C CG1 . VAL A 1 525 ? -18.889 -28.683 27.282 1.00 13.52 ? 551 VAL A CG1 1 ATOM 4058 C CG2 . VAL A 1 525 ? -19.862 -30.126 25.483 1.00 13.51 ? 551 VAL A CG2 1 ATOM 4059 N N . THR A 1 526 ? -15.734 -28.527 26.758 1.00 14.26 ? 552 THR A N 1 ATOM 4060 C CA . THR A 1 526 ? -14.745 -28.055 27.731 1.00 14.79 ? 552 THR A CA 1 ATOM 4061 C C . THR A 1 526 ? -15.144 -26.700 28.333 1.00 15.18 ? 552 THR A C 1 ATOM 4062 O O . THR A 1 526 ? -16.122 -26.082 27.908 1.00 14.90 ? 552 THR A O 1 ATOM 4063 C CB . THR A 1 526 ? -13.352 -27.946 27.083 1.00 14.95 ? 552 THR A CB 1 ATOM 4064 O OG1 . THR A 1 526 ? -13.422 -27.083 25.943 1.00 15.50 ? 552 THR A OG1 1 ATOM 4065 C CG2 . THR A 1 526 ? -12.858 -29.312 26.631 1.00 15.02 ? 552 THR A CG2 1 ATOM 4066 N N . ARG A 1 527 ? -14.384 -26.258 29.336 1.00 15.99 ? 553 ARG A N 1 ATOM 4067 C CA . ARG A 1 527 ? -14.519 -24.910 29.915 1.00 16.52 ? 553 ARG A CA 1 ATOM 4068 C C . ARG A 1 527 ? -15.912 -24.646 30.503 1.00 16.61 ? 553 ARG A C 1 ATOM 4069 O O . ARG A 1 527 ? -16.416 -23.521 30.442 1.00 16.27 ? 553 ARG A O 1 ATOM 4070 C CB . ARG A 1 527 ? -14.155 -23.837 28.872 1.00 17.21 ? 553 ARG A CB 1 ATOM 4071 C CG . ARG A 1 527 ? -12.934 -24.193 28.032 1.00 18.05 ? 553 ARG A CG 1 ATOM 4072 C CD . ARG A 1 527 ? -12.468 -23.067 27.127 1.00 18.87 ? 553 ARG A CD 1 ATOM 4073 N NE . ARG A 1 527 ? -11.579 -22.192 27.868 1.00 20.18 ? 553 ARG A NE 1 ATOM 4074 C CZ . ARG A 1 527 ? -10.261 -22.084 27.714 1.00 20.31 ? 553 ARG A CZ 1 ATOM 4075 N NH1 . ARG A 1 527 ? -9.593 -22.752 26.786 1.00 20.78 ? 553 ARG A NH1 1 ATOM 4076 N NH2 . ARG A 1 527 ? -9.605 -21.260 28.509 1.00 21.02 ? 553 ARG A NH2 1 ATOM 4077 N N . LEU A 1 528 ? -16.528 -25.686 31.067 1.00 16.73 ? 554 LEU A N 1 ATOM 4078 C CA . LEU A 1 528 ? -17.855 -25.562 31.671 1.00 17.05 ? 554 LEU A CA 1 ATOM 4079 C C . LEU A 1 528 ? -17.765 -24.780 32.980 1.00 17.49 ? 554 LEU A C 1 ATOM 4080 O O . LEU A 1 528 ? -16.872 -25.017 33.787 1.00 17.94 ? 554 LEU A O 1 ATOM 4081 C CB . LEU A 1 528 ? -18.475 -26.943 31.925 1.00 16.72 ? 554 LEU A CB 1 ATOM 4082 C CG . LEU A 1 528 ? -19.827 -26.971 32.655 1.00 16.63 ? 554 LEU A CG 1 ATOM 4083 C CD1 . LEU A 1 528 ? -20.896 -26.204 31.891 1.00 16.55 ? 554 LEU A CD1 1 ATOM 4084 C CD2 . LEU A 1 528 ? -20.275 -28.409 32.891 1.00 16.64 ? 554 LEU A CD2 1 ATOM 4085 N N . ARG A 1 529 ? -18.687 -23.847 33.184 1.00 18.09 ? 555 ARG A N 1 ATOM 4086 C CA . ARG A 1 529 ? -18.725 -23.080 34.427 1.00 18.82 ? 555 ARG A CA 1 ATOM 4087 C C . ARG A 1 529 ? -20.169 -22.719 34.769 1.00 18.82 ? 555 ARG A C 1 ATOM 4088 O O . ARG A 1 529 ? -21.006 -22.574 33.874 1.00 18.98 ? 555 ARG A O 1 ATOM 4089 C CB . ARG A 1 529 ? -17.853 -21.828 34.296 1.00 19.23 ? 555 ARG A CB 1 ATOM 4090 C CG . ARG A 1 529 ? -18.441 -20.785 33.363 1.00 19.64 ? 555 ARG A CG 1 ATOM 4091 C CD . ARG A 1 529 ? -17.399 -20.027 32.563 1.00 20.30 ? 555 ARG A CD 1 ATOM 4092 N NE . ARG A 1 529 ? -17.065 -20.723 31.329 1.00 20.63 ? 555 ARG A NE 1 ATOM 4093 C CZ . ARG A 1 529 ? -16.724 -20.147 30.176 1.00 20.64 ? 555 ARG A CZ 1 ATOM 4094 N NH1 . ARG A 1 529 ? -16.658 -18.825 30.043 1.00 20.82 ? 555 ARG A NH1 1 ATOM 4095 N NH2 . ARG A 1 529 ? -16.449 -20.920 29.128 1.00 20.50 ? 555 ARG A NH2 1 ATOM 4096 N N . ALA A 1 530 ? -20.453 -22.603 36.064 1.00 18.95 ? 556 ALA A N 1 ATOM 4097 C CA . ALA A 1 530 ? -21.783 -22.245 36.553 1.00 19.05 ? 556 ALA A CA 1 ATOM 4098 C C . ALA A 1 530 ? -21.721 -20.882 37.237 1.00 19.14 ? 556 ALA A C 1 ATOM 4099 O O . ALA A 1 530 ? -21.031 -20.726 38.243 1.00 19.53 ? 556 ALA A O 1 ATOM 4100 C CB . ALA A 1 530 ? -22.290 -23.298 37.524 1.00 18.93 ? 556 ALA A CB 1 ATOM 4101 N N . LEU A 1 531 ? -22.446 -19.907 36.690 1.00 18.68 ? 557 LEU A N 1 ATOM 4102 C CA . LEU A 1 531 ? -22.438 -18.541 37.202 1.00 18.37 ? 557 LEU A CA 1 ATOM 4103 C C . LEU A 1 531 ? -23.784 -18.192 37.853 1.00 17.88 ? 557 LEU A C 1 ATOM 4104 O O . LEU A 1 531 ? -24.837 -18.439 37.269 1.00 17.65 ? 557 LEU A O 1 ATOM 4105 C CB . LEU A 1 531 ? -22.155 -17.567 36.058 1.00 18.85 ? 557 LEU A CB 1 ATOM 4106 C CG . LEU A 1 531 ? -20.999 -17.892 35.097 1.00 19.15 ? 557 LEU A CG 1 ATOM 4107 C CD1 . LEU A 1 531 ? -21.049 -16.983 33.883 1.00 19.43 ? 557 LEU A CD1 1 ATOM 4108 C CD2 . LEU A 1 531 ? -19.644 -17.779 35.779 1.00 19.22 ? 557 LEU A CD2 1 ATOM 4109 N N . PRO A 1 532 ? -23.757 -17.616 39.067 1.00 17.47 ? 558 PRO A N 1 ATOM 4110 C CA . PRO A 1 532 ? -25.034 -17.284 39.706 1.00 17.22 ? 558 PRO A CA 1 ATOM 4111 C C . PRO A 1 532 ? -25.738 -16.101 39.040 1.00 16.91 ? 558 PRO A C 1 ATOM 4112 O O . PRO A 1 532 ? -25.085 -15.139 38.637 1.00 17.04 ? 558 PRO A O 1 ATOM 4113 C CB . PRO A 1 532 ? -24.649 -16.947 41.160 1.00 17.14 ? 558 PRO A CB 1 ATOM 4114 C CG . PRO A 1 532 ? -23.178 -16.747 41.172 1.00 17.37 ? 558 PRO A CG 1 ATOM 4115 C CD . PRO A 1 532 ? -22.594 -17.381 39.945 1.00 17.46 ? 558 PRO A CD 1 ATOM 4116 N N . LEU A 1 533 ? -27.059 -16.192 38.913 1.00 16.27 ? 559 LEU A N 1 ATOM 4117 C CA . LEU A 1 533 ? -27.878 -15.076 38.433 1.00 15.85 ? 559 LEU A CA 1 ATOM 4118 C C . LEU A 1 533 ? -28.710 -14.494 39.570 1.00 15.85 ? 559 LEU A C 1 ATOM 4119 O O . LEU A 1 533 ? -28.685 -13.290 39.821 1.00 15.21 ? 559 LEU A O 1 ATOM 4120 C CB . LEU A 1 533 ? -28.815 -15.538 37.324 1.00 15.54 ? 559 LEU A CB 1 ATOM 4121 C CG . LEU A 1 533 ? -28.199 -15.868 35.972 1.00 15.42 ? 559 LEU A CG 1 ATOM 4122 C CD1 . LEU A 1 533 ? -29.262 -16.502 35.084 1.00 15.44 ? 559 LEU A CD1 1 ATOM 4123 C CD2 . LEU A 1 533 ? -27.618 -14.620 35.322 1.00 15.31 ? 559 LEU A CD2 1 ATOM 4124 N N . THR A 1 534 ? -29.461 -15.370 40.233 1.00 16.16 ? 560 THR A N 1 ATOM 4125 C CA . THR A 1 534 ? -30.347 -15.003 41.337 1.00 16.59 ? 560 THR A CA 1 ATOM 4126 C C . THR A 1 534 ? -30.782 -16.293 42.046 1.00 17.35 ? 560 THR A C 1 ATOM 4127 O O . THR A 1 534 ? -30.433 -17.396 41.615 1.00 17.09 ? 560 THR A O 1 ATOM 4128 C CB . THR A 1 534 ? -31.582 -14.211 40.830 1.00 16.46 ? 560 THR A CB 1 ATOM 4129 O OG1 . THR A 1 534 ? -32.351 -13.719 41.934 1.00 16.44 ? 560 THR A OG1 1 ATOM 4130 C CG2 . THR A 1 534 ? -32.475 -15.070 39.950 1.00 16.38 ? 560 THR A CG2 1 ATOM 4131 N N . GLN A 1 535 ? -31.539 -16.148 43.125 1.00 18.39 ? 561 GLN A N 1 ATOM 4132 C CA . GLN A 1 535 ? -32.080 -17.297 43.858 1.00 19.61 ? 561 GLN A CA 1 ATOM 4133 C C . GLN A 1 535 ? -32.762 -18.278 42.894 1.00 18.80 ? 561 GLN A C 1 ATOM 4134 O O . GLN A 1 535 ? -33.716 -17.916 42.206 1.00 18.58 ? 561 GLN A O 1 ATOM 4135 C CB . GLN A 1 535 ? -33.077 -16.824 44.928 1.00 20.94 ? 561 GLN A CB 1 ATOM 4136 C CG . GLN A 1 535 ? -33.274 -17.790 46.082 1.00 22.59 ? 561 GLN A CG 1 ATOM 4137 C CD . GLN A 1 535 ? -33.950 -19.089 45.669 1.00 24.43 ? 561 GLN A CD 1 ATOM 4138 O OE1 . GLN A 1 535 ? -34.994 -19.088 44.996 1.00 25.32 ? 561 GLN A OE1 1 ATOM 4139 N NE2 . GLN A 1 535 ? -33.363 -20.213 46.079 1.00 25.67 ? 561 GLN A NE2 1 ATOM 4140 N N . GLY A 1 536 ? -32.246 -19.505 42.836 1.00 17.69 ? 562 GLY A N 1 ATOM 4141 C CA . GLY A 1 536 ? -32.820 -20.561 42.004 1.00 17.14 ? 562 GLY A CA 1 ATOM 4142 C C . GLY A 1 536 ? -32.474 -20.493 40.521 1.00 16.59 ? 562 GLY A C 1 ATOM 4143 O O . GLY A 1 536 ? -33.120 -21.156 39.708 1.00 16.02 ? 562 GLY A O 1 ATOM 4144 N N . GLN A 1 537 ? -31.463 -19.702 40.160 1.00 15.90 ? 563 GLN A N 1 ATOM 4145 C CA . GLN A 1 537 ? -31.073 -19.558 38.758 1.00 15.70 ? 563 GLN A CA 1 ATOM 4146 C C . GLN A 1 537 ? -29.569 -19.433 38.573 1.00 15.48 ? 563 GLN A C 1 ATOM 4147 O O . GLN A 1 537 ? -28.879 -18.825 39.392 1.00 15.33 ? 563 GLN A O 1 ATOM 4148 C CB . GLN A 1 537 ? -31.733 -18.330 38.131 1.00 15.69 ? 563 GLN A CB 1 ATOM 4149 C CG . GLN A 1 537 ? -33.250 -18.296 38.209 1.00 15.61 ? 563 GLN A CG 1 ATOM 4150 C CD . GLN A 1 537 ? -33.820 -17.035 37.585 1.00 15.59 ? 563 GLN A CD 1 ATOM 4151 O OE1 . GLN A 1 537 ? -33.339 -16.570 36.551 1.00 15.39 ? 563 GLN A OE1 1 ATOM 4152 N NE2 . GLN A 1 537 ? -34.838 -16.468 38.216 1.00 15.57 ? 563 GLN A NE2 1 ATOM 4153 N N . LEU A 1 538 ? -29.079 -19.997 37.472 1.00 15.13 ? 564 LEU A N 1 ATOM 4154 C CA . LEU A 1 538 ? -27.685 -19.851 37.080 1.00 14.82 ? 564 LEU A CA 1 ATOM 4155 C C . LEU A 1 538 ? -27.540 -19.904 35.563 1.00 14.57 ? 564 LEU A C 1 ATOM 4156 O O . LEU A 1 538 ? -28.483 -20.254 34.850 1.00 14.65 ? 564 LEU A O 1 ATOM 4157 C CB . LEU A 1 538 ? -26.812 -20.924 37.750 1.00 14.86 ? 564 LEU A CB 1 ATOM 4158 C CG . LEU A 1 538 ? -27.131 -22.400 37.507 1.00 14.94 ? 564 LEU A CG 1 ATOM 4159 C CD1 . LEU A 1 538 ? -26.608 -22.889 36.167 1.00 15.07 ? 564 LEU A CD1 1 ATOM 4160 C CD2 . LEU A 1 538 ? -26.529 -23.241 38.618 1.00 15.08 ? 564 LEU A CD2 1 ATOM 4161 N N . VAL A 1 539 ? -26.355 -19.537 35.085 1.00 14.23 ? 565 VAL A N 1 ATOM 4162 C CA . VAL A 1 539 ? -26.007 -19.652 33.673 1.00 13.99 ? 565 VAL A CA 1 ATOM 4163 C C . VAL A 1 539 ? -24.956 -20.739 33.572 1.00 13.74 ? 565 VAL A C 1 ATOM 4164 O O . VAL A 1 539 ? -23.958 -20.701 34.292 1.00 13.53 ? 565 VAL A O 1 ATOM 4165 C CB . VAL A 1 539 ? -25.369 -18.367 33.081 1.00 14.00 ? 565 VAL A CB 1 ATOM 4166 C CG1 . VAL A 1 539 ? -25.741 -18.224 31.618 1.00 13.94 ? 565 VAL A CG1 1 ATOM 4167 C CG2 . VAL A 1 539 ? -25.773 -17.124 33.844 1.00 14.26 ? 565 VAL A CG2 1 ATOM 4168 N N . LEU A 1 540 ? -25.182 -21.709 32.694 1.00 13.69 ? 566 LEU A N 1 ATOM 4169 C CA . LEU A 1 540 ? -24.142 -22.655 32.331 1.00 13.69 ? 566 LEU A CA 1 ATOM 4170 C C . LEU A 1 540 ? -23.512 -22.134 31.064 1.00 13.42 ? 566 LEU A C 1 ATOM 4171 O O . LEU A 1 540 ? -24.210 -21.875 30.095 1.00 13.27 ? 566 LEU A O 1 ATOM 4172 C CB . LEU A 1 540 ? -24.708 -24.052 32.088 1.00 13.83 ? 566 LEU A CB 1 ATOM 4173 C CG . LEU A 1 540 ? -25.255 -24.743 33.333 1.00 14.03 ? 566 LEU A CG 1 ATOM 4174 C CD1 . LEU A 1 540 ? -26.032 -25.987 32.952 1.00 14.15 ? 566 LEU A CD1 1 ATOM 4175 C CD2 . LEU A 1 540 ? -24.131 -25.086 34.302 1.00 14.06 ? 566 LEU A CD2 1 ATOM 4176 N N . VAL A 1 541 ? -22.197 -21.959 31.093 1.00 13.26 ? 567 VAL A N 1 ATOM 4177 C CA . VAL A 1 541 ? -21.443 -21.527 29.924 1.00 13.10 ? 567 VAL A CA 1 ATOM 4178 C C . VAL A 1 541 ? -20.387 -22.586 29.641 1.00 12.83 ? 567 VAL A C 1 ATOM 4179 O O . VAL A 1 541 ? -19.808 -23.152 30.566 1.00 12.77 ? 567 VAL A O 1 ATOM 4180 C CB . VAL A 1 541 ? -20.741 -20.170 30.167 1.00 13.07 ? 567 VAL A CB 1 ATOM 4181 C CG1 . VAL A 1 541 ? -20.134 -19.641 28.870 1.00 13.23 ? 567 VAL A CG1 1 ATOM 4182 C CG2 . VAL A 1 541 ? -21.714 -19.156 30.736 1.00 13.19 ? 567 VAL A CG2 1 ATOM 4183 N N . TRP A 1 542 ? -20.131 -22.848 28.367 1.00 12.66 ? 568 TRP A N 1 ATOM 4184 C CA . TRP A 1 542 ? -19.100 -23.805 27.994 1.00 12.65 ? 568 TRP A CA 1 ATOM 4185 C C . TRP A 1 542 ? -18.516 -23.455 26.632 1.00 12.88 ? 568 TRP A C 1 ATOM 4186 O O . TRP A 1 542 ? -18.997 -22.538 25.975 1.00 12.86 ? 568 TRP A O 1 ATOM 4187 C CB . TRP A 1 542 ? -19.676 -25.225 28.010 1.00 12.33 ? 568 TRP A CB 1 ATOM 4188 C CG . TRP A 1 542 ? -20.787 -25.437 27.045 1.00 12.02 ? 568 TRP A CG 1 ATOM 4189 C CD1 . TRP A 1 542 ? -20.672 -25.824 25.746 1.00 12.09 ? 568 TRP A CD1 1 ATOM 4190 C CD2 . TRP A 1 542 ? -22.188 -25.291 27.299 1.00 11.80 ? 568 TRP A CD2 1 ATOM 4191 N NE1 . TRP A 1 542 ? -21.913 -25.925 25.168 1.00 11.91 ? 568 TRP A NE1 1 ATOM 4192 C CE2 . TRP A 1 542 ? -22.863 -25.602 26.098 1.00 11.75 ? 568 TRP A CE2 1 ATOM 4193 C CE3 . TRP A 1 542 ? -22.942 -24.933 28.424 1.00 11.58 ? 568 TRP A CE3 1 ATOM 4194 C CZ2 . TRP A 1 542 ? -24.254 -25.557 25.987 1.00 11.57 ? 568 TRP A CZ2 1 ATOM 4195 C CZ3 . TRP A 1 542 ? -24.326 -24.879 28.310 1.00 11.52 ? 568 TRP A CZ3 1 ATOM 4196 C CH2 . TRP A 1 542 ? -24.967 -25.198 27.103 1.00 11.55 ? 568 TRP A CH2 1 ATOM 4197 N N . SER A 1 543 ? -17.475 -24.183 26.228 1.00 13.28 ? 569 SER A N 1 ATOM 4198 C CA . SER A 1 543 ? -16.838 -24.001 24.925 1.00 13.61 ? 569 SER A CA 1 ATOM 4199 C C . SER A 1 543 ? -17.036 -25.229 24.042 1.00 14.18 ? 569 SER A C 1 ATOM 4200 O O . SER A 1 543 ? -17.058 -26.361 24.529 1.00 14.34 ? 569 SER A O 1 ATOM 4201 C CB . SER A 1 543 ? -15.341 -23.744 25.103 1.00 13.70 ? 569 SER A CB 1 ATOM 4202 O OG . SER A 1 543 ? -14.672 -23.792 23.858 1.00 13.79 ? 569 SER A OG 1 ATOM 4203 N N . ASP A 1 544 ? -17.165 -24.995 22.739 1.00 14.83 ? 570 ASP A N 1 ATOM 4204 C CA . ASP A 1 544 ? -17.244 -26.071 21.752 1.00 15.45 ? 570 ASP A CA 1 ATOM 4205 C C . ASP A 1 544 ? -15.945 -26.205 20.944 1.00 16.06 ? 570 ASP A C 1 ATOM 4206 O O . ASP A 1 544 ? -15.941 -26.789 19.868 1.00 15.88 ? 570 ASP A O 1 ATOM 4207 C CB . ASP A 1 544 ? -18.437 -25.851 20.812 1.00 15.29 ? 570 ASP A CB 1 ATOM 4208 C CG . ASP A 1 544 ? -18.311 -24.587 19.980 1.00 15.29 ? 570 ASP A CG 1 ATOM 4209 O OD1 . ASP A 1 544 ? -17.364 -23.808 20.209 1.00 15.63 ? 570 ASP A OD1 1 ATOM 4210 O OD2 . ASP A 1 544 ? -19.174 -24.356 19.114 1.00 15.13 ? 570 ASP A OD2 1 ATOM 4211 N N . GLU A 1 545 ? -14.847 -25.682 21.483 1.00 17.51 ? 571 GLU A N 1 ATOM 4212 C CA . GLU A 1 545 ? -13.555 -25.666 20.789 1.00 18.39 ? 571 GLU A CA 1 ATOM 4213 C C . GLU A 1 545 ? -13.009 -27.047 20.420 1.00 18.56 ? 571 GLU A C 1 ATOM 4214 O O . GLU A 1 545 ? -12.229 -27.156 19.483 1.00 18.65 ? 571 GLU A O 1 ATOM 4215 C CB . GLU A 1 545 ? -12.513 -24.917 21.626 1.00 19.69 ? 571 GLU A CB 1 ATOM 4216 C CG . GLU A 1 545 ? -12.157 -25.607 22.943 1.00 20.98 ? 571 GLU A CG 1 ATOM 4217 C CD . GLU A 1 545 ? -11.159 -24.833 23.789 1.00 22.13 ? 571 GLU A CD 1 ATOM 4218 O OE1 . GLU A 1 545 ? -10.835 -25.324 24.901 1.00 23.71 ? 571 GLU A OE1 1 ATOM 4219 O OE2 . GLU A 1 545 ? -10.701 -23.752 23.348 1.00 22.36 ? 571 GLU A OE2 1 ATOM 4220 N N . HIS A 1 546 ? -13.398 -28.093 21.149 1.00 19.09 ? 572 HIS A N 1 ATOM 4221 C CA . HIS A 1 546 ? -12.934 -29.458 20.850 1.00 19.66 ? 572 HIS A CA 1 ATOM 4222 C C . HIS A 1 546 ? -14.041 -30.437 20.462 1.00 19.54 ? 572 HIS A C 1 ATOM 4223 O O . HIS A 1 546 ? -13.786 -31.639 20.399 1.00 19.57 ? 572 HIS A O 1 ATOM 4224 C CB . HIS A 1 546 ? -12.164 -30.046 22.043 1.00 20.30 ? 572 HIS A CB 1 ATOM 4225 C CG . HIS A 1 546 ? -10.903 -29.315 22.372 1.00 21.03 ? 572 HIS A CG 1 ATOM 4226 N ND1 . HIS A 1 546 ? -10.399 -29.245 23.652 1.00 21.79 ? 572 HIS A ND1 1 ATOM 4227 C CD2 . HIS A 1 546 ? -10.046 -28.617 21.591 1.00 21.67 ? 572 HIS A CD2 1 ATOM 4228 C CE1 . HIS A 1 546 ? -9.286 -28.533 23.646 1.00 22.14 ? 572 HIS A CE1 1 ATOM 4229 N NE2 . HIS A 1 546 ? -9.050 -28.139 22.407 1.00 22.12 ? 572 HIS A NE2 1 ATOM 4230 N N . VAL A 1 547 ? -15.253 -29.953 20.186 1.00 19.41 ? 573 VAL A N 1 ATOM 4231 C CA . VAL A 1 547 ? -16.348 -30.865 19.831 1.00 19.32 ? 573 VAL A CA 1 ATOM 4232 C C . VAL A 1 547 ? -16.194 -31.411 18.414 1.00 18.97 ? 573 VAL A C 1 ATOM 4233 O O . VAL A 1 547 ? -16.673 -32.506 18.123 1.00 18.22 ? 573 VAL A O 1 ATOM 4234 C CB . VAL A 1 547 ? -17.754 -30.243 19.996 1.00 19.61 ? 573 VAL A CB 1 ATOM 4235 C CG1 . VAL A 1 547 ? -17.924 -29.684 21.404 1.00 19.97 ? 573 VAL A CG1 1 ATOM 4236 C CG2 . VAL A 1 547 ? -18.019 -29.183 18.939 1.00 20.10 ? 573 VAL A CG2 1 ATOM 4237 N N . GLY A 1 548 ? -15.527 -30.645 17.551 1.00 18.95 ? 574 GLY A N 1 ATOM 4238 C CA . GLY A 1 548 ? -15.255 -31.055 16.177 1.00 19.02 ? 574 GLY A CA 1 ATOM 4239 C C . GLY A 1 548 ? -16.363 -30.679 15.208 1.00 18.76 ? 574 GLY A C 1 ATOM 4240 O O . GLY A 1 548 ? -16.548 -29.509 14.891 1.00 19.12 ? 574 GLY A O 1 ATOM 4241 N N . SER A 1 549 ? -17.105 -31.682 14.755 1.00 18.54 ? 575 SER A N 1 ATOM 4242 C CA . SER A 1 549 ? -18.095 -31.517 13.694 1.00 18.37 ? 575 SER A CA 1 ATOM 4243 C C . SER A 1 549 ? -19.221 -30.534 14.024 1.00 17.51 ? 575 SER A C 1 ATOM 4244 O O . SER A 1 549 ? -19.621 -30.383 15.177 1.00 17.16 ? 575 SER A O 1 ATOM 4245 C CB . SER A 1 549 ? -18.708 -32.873 13.335 1.00 18.89 ? 575 SER A CB 1 ATOM 4246 O OG . SER A 1 549 ? -19.513 -32.752 12.176 1.00 19.91 ? 575 SER A OG 1 ATOM 4247 N N . LYS A 1 550 ? -19.734 -29.884 12.986 1.00 16.80 ? 576 LYS A N 1 ATOM 4248 C CA . LYS A 1 550 ? -20.851 -28.951 13.124 1.00 16.28 ? 576 LYS A CA 1 ATOM 4249 C C . LYS A 1 550 ? -22.229 -29.619 13.054 1.00 15.85 ? 576 LYS A C 1 ATOM 4250 O O . LYS A 1 550 ? -23.246 -28.941 13.212 1.00 15.62 ? 576 LYS A O 1 ATOM 4251 C CB . LYS A 1 550 ? -20.783 -27.880 12.034 1.00 16.33 ? 576 LYS A CB 1 ATOM 4252 C CG . LYS A 1 550 ? -19.588 -26.956 12.109 1.00 16.25 ? 576 LYS A CG 1 ATOM 4253 C CD . LYS A 1 550 ? -19.732 -25.857 11.077 1.00 16.26 ? 576 LYS A CD 1 ATOM 4254 C CE . LYS A 1 550 ? -18.602 -24.855 11.162 1.00 16.56 ? 576 LYS A CE 1 ATOM 4255 N NZ . LYS A 1 550 ? -18.713 -23.826 10.093 1.00 16.82 ? 576 LYS A NZ 1 ATOM 4256 N N A CYS A 1 551 ? -22.278 -30.927 12.811 0.50 15.70 ? 577 CYS A N 1 ATOM 4257 N N B CYS A 1 551 ? -22.254 -30.934 12.832 0.50 15.69 ? 577 CYS A N 1 ATOM 4258 C CA A CYS A 1 551 ? -23.557 -31.620 12.663 0.50 15.45 ? 577 CYS A CA 1 ATOM 4259 C CA B CYS A 1 551 ? -23.502 -31.687 12.697 0.50 15.44 ? 577 CYS A CA 1 ATOM 4260 C C A CYS A 1 551 ? -24.132 -31.972 14.033 0.50 15.27 ? 577 CYS A C 1 ATOM 4261 C C B CYS A 1 551 ? -24.123 -31.986 14.056 0.50 15.26 ? 577 CYS A C 1 ATOM 4262 O O A CYS A 1 551 ? -24.393 -33.141 14.330 0.50 15.12 ? 577 CYS A O 1 ATOM 4263 O O B CYS A 1 551 ? -24.418 -33.143 14.367 0.50 15.11 ? 577 CYS A O 1 ATOM 4264 C CB A CYS A 1 551 ? -23.391 -32.867 11.793 0.50 15.54 ? 577 CYS A CB 1 ATOM 4265 C CB B CYS A 1 551 ? -23.245 -33.000 11.950 0.50 15.52 ? 577 CYS A CB 1 ATOM 4266 S SG A CYS A 1 551 ? -22.522 -32.550 10.236 0.50 15.58 ? 577 CYS A SG 1 ATOM 4267 S SG B CYS A 1 551 ? -21.838 -33.959 12.569 0.50 15.58 ? 577 CYS A SG 1 ATOM 4268 N N . LEU A 1 552 ? -24.336 -30.937 14.849 1.00 15.05 ? 578 LEU A N 1 ATOM 4269 C CA . LEU A 1 552 ? -24.821 -31.079 16.221 1.00 14.92 ? 578 LEU A CA 1 ATOM 4270 C C . LEU A 1 552 ? -26.293 -30.708 16.358 1.00 14.35 ? 578 LEU A C 1 ATOM 4271 O O . LEU A 1 552 ? -26.739 -29.677 15.847 1.00 14.17 ? 578 LEU A O 1 ATOM 4272 C CB . LEU A 1 552 ? -23.987 -30.210 17.167 1.00 15.23 ? 578 LEU A CB 1 ATOM 4273 C CG . LEU A 1 552 ? -22.529 -30.633 17.357 1.00 15.65 ? 578 LEU A CG 1 ATOM 4274 C CD1 . LEU A 1 552 ? -21.834 -29.724 18.358 1.00 15.80 ? 578 LEU A CD1 1 ATOM 4275 C CD2 . LEU A 1 552 ? -22.433 -32.084 17.809 1.00 15.81 ? 578 LEU A CD2 1 ATOM 4276 N N . TRP A 1 553 ? -27.039 -31.557 17.058 1.00 13.81 ? 579 TRP A N 1 ATOM 4277 C CA . TRP A 1 553 ? -28.461 -31.328 17.290 1.00 13.65 ? 579 TRP A CA 1 ATOM 4278 C C . TRP A 1 553 ? -28.642 -30.406 18.489 1.00 13.57 ? 579 TRP A C 1 ATOM 4279 O O . TRP A 1 553 ? -29.409 -29.441 18.439 1.00 13.39 ? 579 TRP A O 1 ATOM 4280 C CB . TRP A 1 553 ? -29.184 -32.653 17.529 1.00 13.68 ? 579 TRP A CB 1 ATOM 4281 C CG . TRP A 1 553 ? -30.623 -32.480 17.851 1.00 13.66 ? 579 TRP A CG 1 ATOM 4282 C CD1 . TRP A 1 553 ? -31.233 -32.758 19.033 1.00 13.64 ? 579 TRP A CD1 1 ATOM 4283 C CD2 . TRP A 1 553 ? -31.640 -31.965 16.984 1.00 13.68 ? 579 TRP A CD2 1 ATOM 4284 N NE1 . TRP A 1 553 ? -32.570 -32.456 18.959 1.00 13.64 ? 579 TRP A NE1 1 ATOM 4285 C CE2 . TRP A 1 553 ? -32.846 -31.964 17.712 1.00 13.73 ? 579 TRP A CE2 1 ATOM 4286 C CE3 . TRP A 1 553 ? -31.648 -31.509 15.665 1.00 13.67 ? 579 TRP A CE3 1 ATOM 4287 C CZ2 . TRP A 1 553 ? -34.052 -31.527 17.162 1.00 13.76 ? 579 TRP A CZ2 1 ATOM 4288 C CZ3 . TRP A 1 553 ? -32.844 -31.073 15.120 1.00 13.70 ? 579 TRP A CZ3 1 ATOM 4289 C CH2 . TRP A 1 553 ? -34.030 -31.085 15.867 1.00 13.76 ? 579 TRP A CH2 1 ATOM 4290 N N . THR A 1 554 ? -27.931 -30.714 19.568 1.00 13.30 ? 580 THR A N 1 ATOM 4291 C CA . THR A 1 554 ? -28.023 -29.930 20.787 1.00 13.31 ? 580 THR A CA 1 ATOM 4292 C C . THR A 1 554 ? -26.877 -30.303 21.719 1.00 13.39 ? 580 THR A C 1 ATOM 4293 O O . THR A 1 554 ? -26.073 -31.189 21.406 1.00 13.39 ? 580 THR A O 1 ATOM 4294 C CB . THR A 1 554 ? -29.372 -30.174 21.501 1.00 13.22 ? 580 THR A CB 1 ATOM 4295 O OG1 . THR A 1 554 ? -29.551 -29.222 22.557 1.00 13.16 ? 580 THR A OG1 1 ATOM 4296 C CG2 . THR A 1 554 ? -29.448 -31.600 22.070 1.00 13.28 ? 580 THR A CG2 1 ATOM 4297 N N . TYR A 1 555 ? -26.804 -29.609 22.852 1.00 13.54 ? 581 TYR A N 1 ATOM 4298 C CA . TYR A 1 555 ? -25.951 -30.021 23.960 1.00 13.46 ? 581 TYR A CA 1 ATOM 4299 C C . TYR A 1 555 ? -26.822 -30.561 25.082 1.00 13.70 ? 581 TYR A C 1 ATOM 4300 O O . TYR A 1 555 ? -27.698 -29.857 25.590 1.00 13.62 ? 581 TYR A O 1 ATOM 4301 C CB . TYR A 1 555 ? -25.089 -28.858 24.447 1.00 13.49 ? 581 TYR A CB 1 ATOM 4302 C CG . TYR A 1 555 ? -23.980 -28.538 23.482 1.00 13.44 ? 581 TYR A CG 1 ATOM 4303 C CD1 . TYR A 1 555 ? -22.797 -29.257 23.502 1.00 13.36 ? 581 TYR A CD1 1 ATOM 4304 C CD2 . TYR A 1 555 ? -24.127 -27.536 22.527 1.00 13.45 ? 581 TYR A CD2 1 ATOM 4305 C CE1 . TYR A 1 555 ? -21.778 -28.985 22.608 1.00 13.59 ? 581 TYR A CE1 1 ATOM 4306 C CE2 . TYR A 1 555 ? -23.116 -27.255 21.625 1.00 13.53 ? 581 TYR A CE2 1 ATOM 4307 C CZ . TYR A 1 555 ? -21.946 -27.983 21.669 1.00 13.65 ? 581 TYR A CZ 1 ATOM 4308 O OH . TYR A 1 555 ? -20.936 -27.719 20.781 1.00 14.00 ? 581 TYR A OH 1 ATOM 4309 N N . GLU A 1 556 ? -26.593 -31.820 25.451 1.00 13.82 ? 582 GLU A N 1 ATOM 4310 C CA . GLU A 1 556 ? -27.325 -32.429 26.549 1.00 14.13 ? 582 GLU A CA 1 ATOM 4311 C C . GLU A 1 556 ? -26.747 -31.911 27.863 1.00 13.91 ? 582 GLU A C 1 ATOM 4312 O O . GLU A 1 556 ? -25.577 -32.139 28.160 1.00 13.70 ? 582 GLU A O 1 ATOM 4313 C CB . GLU A 1 556 ? -27.249 -33.965 26.490 1.00 14.43 ? 582 GLU A CB 1 ATOM 4314 C CG . GLU A 1 556 ? -28.008 -34.645 27.626 1.00 14.78 ? 582 GLU A CG 1 ATOM 4315 C CD . GLU A 1 556 ? -28.090 -36.162 27.514 1.00 15.08 ? 582 GLU A CD 1 ATOM 4316 O OE1 . GLU A 1 556 ? -27.585 -36.745 26.527 1.00 15.27 ? 582 GLU A OE1 1 ATOM 4317 O OE2 . GLU A 1 556 ? -28.681 -36.777 28.431 1.00 15.35 ? 582 GLU A OE2 1 ATOM 4318 N N . ILE A 1 557 ? -27.566 -31.199 28.630 1.00 14.00 ? 583 ILE A N 1 ATOM 4319 C CA . ILE A 1 557 ? -27.186 -30.711 29.956 1.00 14.12 ? 583 ILE A CA 1 ATOM 4320 C C . ILE A 1 557 ? -27.780 -31.661 30.988 1.00 14.51 ? 583 ILE A C 1 ATOM 4321 O O . ILE A 1 557 ? -28.965 -31.982 30.919 1.00 14.43 ? 583 ILE A O 1 ATOM 4322 C CB . ILE A 1 557 ? -27.727 -29.291 30.202 1.00 14.13 ? 583 ILE A CB 1 ATOM 4323 C CG1 . ILE A 1 557 ? -27.223 -28.340 29.108 1.00 14.12 ? 583 ILE A CG1 1 ATOM 4324 C CG2 . ILE A 1 557 ? -27.330 -28.788 31.585 1.00 14.06 ? 583 ILE A CG2 1 ATOM 4325 C CD1 . ILE A 1 557 ? -27.791 -26.941 29.192 1.00 14.07 ? 583 ILE A CD1 1 ATOM 4326 N N . GLN A 1 558 ? -26.957 -32.103 31.937 1.00 15.18 ? 584 GLN A N 1 ATOM 4327 C CA . GLN A 1 558 ? -27.404 -32.994 33.006 1.00 15.66 ? 584 GLN A CA 1 ATOM 4328 C C . GLN A 1 558 ? -27.096 -32.411 34.379 1.00 16.57 ? 584 GLN A C 1 ATOM 4329 O O . GLN A 1 558 ? -26.044 -31.808 34.582 1.00 16.42 ? 584 GLN A O 1 ATOM 4330 C CB . GLN A 1 558 ? -26.754 -34.367 32.871 1.00 15.38 ? 584 GLN A CB 1 ATOM 4331 C CG . GLN A 1 558 ? -27.190 -35.113 31.625 1.00 15.24 ? 584 GLN A CG 1 ATOM 4332 C CD . GLN A 1 558 ? -26.786 -36.573 31.636 1.00 15.05 ? 584 GLN A CD 1 ATOM 4333 O OE1 . GLN A 1 558 ? -25.918 -36.984 32.401 1.00 15.04 ? 584 GLN A OE1 1 ATOM 4334 N NE2 . GLN A 1 558 ? -27.403 -37.361 30.768 1.00 14.96 ? 584 GLN A NE2 1 ATOM 4335 N N . PHE A 1 559 ? -28.026 -32.614 35.311 1.00 17.69 ? 585 PHE A N 1 ATOM 4336 C CA . PHE A 1 559 ? -27.925 -32.091 36.661 1.00 18.85 ? 585 PHE A CA 1 ATOM 4337 C C . PHE A 1 559 ? -28.018 -33.238 37.666 1.00 20.17 ? 585 PHE A C 1 ATOM 4338 O O . PHE A 1 559 ? -28.837 -34.141 37.508 1.00 19.92 ? 585 PHE A O 1 ATOM 4339 C CB . PHE A 1 559 ? -29.041 -31.068 36.885 1.00 19.11 ? 585 PHE A CB 1 ATOM 4340 C CG . PHE A 1 559 ? -29.130 -30.544 38.290 1.00 19.25 ? 585 PHE A CG 1 ATOM 4341 C CD1 . PHE A 1 559 ? -28.002 -30.062 38.944 1.00 19.34 ? 585 PHE A CD1 1 ATOM 4342 C CD2 . PHE A 1 559 ? -30.352 -30.498 38.946 1.00 19.41 ? 585 PHE A CD2 1 ATOM 4343 C CE1 . PHE A 1 559 ? -28.088 -29.563 40.230 1.00 19.47 ? 585 PHE A CE1 1 ATOM 4344 C CE2 . PHE A 1 559 ? -30.444 -30.004 40.234 1.00 19.69 ? 585 PHE A CE2 1 ATOM 4345 C CZ . PHE A 1 559 ? -29.311 -29.536 40.879 1.00 19.65 ? 585 PHE A CZ 1 ATOM 4346 N N . SER A 1 560 ? -27.160 -33.198 38.684 1.00 22.10 ? 586 SER A N 1 ATOM 4347 C CA . SER A 1 560 ? -27.161 -34.192 39.759 1.00 24.16 ? 586 SER A CA 1 ATOM 4348 C C . SER A 1 560 ? -27.216 -33.519 41.128 1.00 26.02 ? 586 SER A C 1 ATOM 4349 O O . SER A 1 560 ? -26.387 -32.670 41.437 1.00 26.24 ? 586 SER A O 1 ATOM 4350 C CB . SER A 1 560 ? -25.908 -35.069 39.684 1.00 24.35 ? 586 SER A CB 1 ATOM 4351 O OG . SER A 1 560 ? -25.844 -35.963 40.788 1.00 24.30 ? 586 SER A OG 1 ATOM 4352 N N . GLN A 1 561 ? -28.211 -33.892 41.927 1.00 29.04 ? 587 GLN A N 1 ATOM 4353 C CA . GLN A 1 561 ? -28.261 -33.538 43.343 1.00 32.35 ? 587 GLN A CA 1 ATOM 4354 C C . GLN A 1 561 ? -27.816 -34.766 44.129 1.00 36.09 ? 587 GLN A C 1 ATOM 4355 O O . GLN A 1 561 ? -26.850 -34.708 44.888 1.00 37.07 ? 587 GLN A O 1 ATOM 4356 C CB . GLN A 1 561 ? -29.682 -33.144 43.763 1.00 32.61 ? 587 GLN A CB 1 ATOM 4357 C CG . GLN A 1 561 ? -30.312 -32.054 42.910 1.00 33.19 ? 587 GLN A CG 1 ATOM 4358 C CD . GLN A 1 561 ? -31.804 -31.890 43.163 1.00 33.17 ? 587 GLN A CD 1 ATOM 4359 O OE1 . GLN A 1 561 ? -32.216 -31.473 44.242 1.00 32.52 ? 587 GLN A OE1 1 ATOM 4360 N NE2 . GLN A 1 561 ? -32.620 -32.205 42.159 1.00 33.91 ? 587 GLN A NE2 1 ATOM 4361 N N . ASP A 1 562 ? -28.517 -35.880 43.907 1.00 40.18 ? 588 ASP A N 1 ATOM 4362 C CA . ASP A 1 562 ? -28.291 -37.131 44.639 1.00 43.51 ? 588 ASP A CA 1 ATOM 4363 C C . ASP A 1 562 ? -26.901 -37.677 44.339 1.00 43.27 ? 588 ASP A C 1 ATOM 4364 O O . ASP A 1 562 ? -26.733 -38.517 43.447 1.00 40.93 ? 588 ASP A O 1 ATOM 4365 C CB . ASP A 1 562 ? -29.362 -38.181 44.280 1.00 45.48 ? 588 ASP A CB 1 ATOM 4366 C CG . ASP A 1 562 ? -30.783 -37.701 44.570 1.00 46.76 ? 588 ASP A CG 1 ATOM 4367 O OD1 . ASP A 1 562 ? -31.309 -36.883 43.784 1.00 46.70 ? 588 ASP A OD1 1 ATOM 4368 O OD2 . ASP A 1 562 ? -31.375 -38.150 45.577 1.00 48.46 ? 588 ASP A OD2 1 ATOM 4369 N N . GLY A 1 563 ? -25.915 -37.178 45.088 1.00 43.29 ? 589 GLY A N 1 ATOM 4370 C CA . GLY A 1 563 ? -24.510 -37.536 44.888 1.00 43.10 ? 589 GLY A CA 1 ATOM 4371 C C . GLY A 1 563 ? -24.091 -37.385 43.437 1.00 43.31 ? 589 GLY A C 1 ATOM 4372 O O . GLY A 1 563 ? -23.666 -36.304 43.009 1.00 43.08 ? 589 GLY A O 1 ATOM 4373 N N . LYS A 1 564 ? -24.232 -38.475 42.682 1.00 41.10 ? 590 LYS A N 1 ATOM 4374 C CA . LYS A 1 564 ? -23.923 -38.478 41.256 1.00 38.67 ? 590 LYS A CA 1 ATOM 4375 C C . LYS A 1 564 ? -24.832 -39.415 40.438 1.00 35.66 ? 590 LYS A C 1 ATOM 4376 O O . LYS A 1 564 ? -24.354 -40.253 39.673 1.00 34.56 ? 590 LYS A O 1 ATOM 4377 C CB . LYS A 1 564 ? -22.434 -38.771 41.026 1.00 39.94 ? 590 LYS A CB 1 ATOM 4378 C CG . LYS A 1 564 ? -21.545 -37.538 41.147 1.00 40.90 ? 590 LYS A CG 1 ATOM 4379 C CD . LYS A 1 564 ? -20.325 -37.629 40.236 1.00 42.24 ? 590 LYS A CD 1 ATOM 4380 C CE . LYS A 1 564 ? -19.781 -36.257 39.863 1.00 42.41 ? 590 LYS A CE 1 ATOM 4381 N NZ . LYS A 1 564 ? -18.958 -35.630 40.934 1.00 43.03 ? 590 LYS A NZ 1 ATOM 4382 N N . ALA A 1 565 ? -26.145 -39.254 40.618 1.00 32.31 ? 591 ALA A N 1 ATOM 4383 C CA . ALA A 1 565 ? -27.136 -39.710 39.643 1.00 29.27 ? 591 ALA A CA 1 ATOM 4384 C C . ALA A 1 565 ? -27.532 -38.488 38.810 1.00 27.01 ? 591 ALA A C 1 ATOM 4385 O O . ALA A 1 565 ? -28.006 -37.495 39.361 1.00 27.17 ? 591 ALA A O 1 ATOM 4386 C CB . ALA A 1 565 ? -28.346 -40.295 40.343 1.00 29.01 ? 591 ALA A CB 1 ATOM 4387 N N . TYR A 1 566 ? -27.326 -38.555 37.496 1.00 24.20 ? 592 TYR A N 1 ATOM 4388 C CA . TYR A 1 566 ? -27.482 -37.386 36.624 1.00 22.36 ? 592 TYR A CA 1 ATOM 4389 C C . TYR A 1 566 ? -28.753 -37.440 35.780 1.00 21.10 ? 592 TYR A C 1 ATOM 4390 O O . TYR A 1 566 ? -29.083 -38.476 35.217 1.00 20.69 ? 592 TYR A O 1 ATOM 4391 C CB . TYR A 1 566 ? -26.258 -37.236 35.718 1.00 22.16 ? 592 TYR A CB 1 ATOM 4392 C CG . TYR A 1 566 ? -25.098 -36.533 36.384 1.00 22.20 ? 592 TYR A CG 1 ATOM 4393 C CD1 . TYR A 1 566 ? -24.963 -35.149 36.310 1.00 22.13 ? 592 TYR A CD1 1 ATOM 4394 C CD2 . TYR A 1 566 ? -24.140 -37.248 37.095 1.00 22.36 ? 592 TYR A CD2 1 ATOM 4395 C CE1 . TYR A 1 566 ? -23.903 -34.500 36.918 1.00 22.32 ? 592 TYR A CE1 1 ATOM 4396 C CE2 . TYR A 1 566 ? -23.078 -36.606 37.712 1.00 22.19 ? 592 TYR A CE2 1 ATOM 4397 C CZ . TYR A 1 566 ? -22.964 -35.234 37.618 1.00 22.28 ? 592 TYR A CZ 1 ATOM 4398 O OH . TYR A 1 566 ? -21.913 -34.595 38.227 1.00 22.51 ? 592 TYR A OH 1 ATOM 4399 N N . THR A 1 567 ? -29.448 -36.305 35.696 1.00 19.72 ? 593 THR A N 1 ATOM 4400 C CA . THR A 1 567 ? -30.719 -36.200 34.986 1.00 18.63 ? 593 THR A CA 1 ATOM 4401 C C . THR A 1 567 ? -30.645 -35.097 33.932 1.00 17.86 ? 593 THR A C 1 ATOM 4402 O O . THR A 1 567 ? -30.281 -33.967 34.259 1.00 17.50 ? 593 THR A O 1 ATOM 4403 C CB . THR A 1 567 ? -31.859 -35.842 35.959 1.00 18.50 ? 593 THR A CB 1 ATOM 4404 O OG1 . THR A 1 567 ? -31.957 -36.845 36.975 1.00 18.80 ? 593 THR A OG1 1 ATOM 4405 C CG2 . THR A 1 567 ? -33.195 -35.729 35.231 1.00 18.33 ? 593 THR A CG2 1 ATOM 4406 N N . PRO A 1 568 ? -31.020 -35.408 32.673 1.00 17.31 ? 594 PRO A N 1 ATOM 4407 C CA . PRO A 1 568 ? -30.999 -34.377 31.635 1.00 17.14 ? 594 PRO A CA 1 ATOM 4408 C C . PRO A 1 568 ? -32.008 -33.257 31.869 1.00 17.12 ? 594 PRO A C 1 ATOM 4409 O O . PRO A 1 568 ? -33.083 -33.485 32.415 1.00 16.51 ? 594 PRO A O 1 ATOM 4410 C CB . PRO A 1 568 ? -31.348 -35.136 30.350 1.00 17.34 ? 594 PRO A CB 1 ATOM 4411 C CG . PRO A 1 568 ? -31.981 -36.403 30.781 1.00 17.44 ? 594 PRO A CG 1 ATOM 4412 C CD . PRO A 1 568 ? -31.449 -36.718 32.151 1.00 17.46 ? 594 PRO A CD 1 ATOM 4413 N N . VAL A 1 569 ? -31.645 -32.052 31.458 1.00 17.05 ? 595 VAL A N 1 ATOM 4414 C CA . VAL A 1 569 ? -32.546 -30.917 31.544 1.00 17.18 ? 595 VAL A CA 1 ATOM 4415 C C . VAL A 1 569 ? -33.251 -30.792 30.199 1.00 17.15 ? 595 VAL A C 1 ATOM 4416 O O . VAL A 1 569 ? -32.620 -30.457 29.198 1.00 17.18 ? 595 VAL A O 1 ATOM 4417 C CB . VAL A 1 569 ? -31.776 -29.630 31.882 1.00 17.00 ? 595 VAL A CB 1 ATOM 4418 C CG1 . VAL A 1 569 ? -32.719 -28.438 31.952 1.00 17.13 ? 595 VAL A CG1 1 ATOM 4419 C CG2 . VAL A 1 569 ? -31.038 -29.802 33.198 1.00 16.90 ? 595 VAL A CG2 1 ATOM 4420 N N . SER A 1 570 ? -34.550 -31.082 30.175 1.00 17.16 ? 596 SER A N 1 ATOM 4421 C CA . SER A 1 570 ? -35.334 -30.962 28.949 1.00 17.36 ? 596 SER A CA 1 ATOM 4422 C C . SER A 1 570 ? -35.393 -29.500 28.535 1.00 16.87 ? 596 SER A C 1 ATOM 4423 O O . SER A 1 570 ? -35.625 -28.615 29.359 1.00 16.84 ? 596 SER A O 1 ATOM 4424 C CB . SER A 1 570 ? -36.758 -31.503 29.123 1.00 17.81 ? 596 SER A CB 1 ATOM 4425 O OG . SER A 1 570 ? -36.751 -32.801 29.687 1.00 19.15 ? 596 SER A OG 1 ATOM 4426 N N . ARG A 1 571 ? -35.166 -29.259 27.251 1.00 16.33 ? 597 ARG A N 1 ATOM 4427 C CA . ARG A 1 571 ? -35.128 -27.909 26.715 1.00 15.95 ? 597 ARG A CA 1 ATOM 4428 C C . ARG A 1 571 ? -35.197 -27.966 25.200 1.00 16.17 ? 597 ARG A C 1 ATOM 4429 O O . ARG A 1 571 ? -35.015 -29.029 24.605 1.00 15.52 ? 597 ARG A O 1 ATOM 4430 C CB . ARG A 1 571 ? -33.846 -27.192 27.152 1.00 15.37 ? 597 ARG A CB 1 ATOM 4431 C CG . ARG A 1 571 ? -32.554 -27.800 26.624 1.00 14.89 ? 597 ARG A CG 1 ATOM 4432 C CD . ARG A 1 571 ? -31.373 -27.389 27.488 1.00 14.45 ? 597 ARG A CD 1 ATOM 4433 N NE . ARG A 1 571 ? -30.085 -27.589 26.827 1.00 14.21 ? 597 ARG A NE 1 ATOM 4434 C CZ . ARG A 1 571 ? -29.447 -26.683 26.082 1.00 13.91 ? 597 ARG A CZ 1 ATOM 4435 N NH1 . ARG A 1 571 ? -29.966 -25.477 25.864 1.00 13.72 ? 597 ARG A NH1 1 ATOM 4436 N NH2 . ARG A 1 571 ? -28.273 -26.990 25.545 1.00 13.74 ? 597 ARG A NH2 1 ATOM 4437 N N . LYS A 1 572 ? -35.460 -26.818 24.584 1.00 16.63 ? 598 LYS A N 1 ATOM 4438 C CA . LYS A 1 572 ? -35.459 -26.720 23.131 1.00 17.07 ? 598 LYS A CA 1 ATOM 4439 C C . LYS A 1 572 ? -34.074 -27.056 22.579 1.00 16.78 ? 598 LYS A C 1 ATOM 4440 O O . LYS A 1 572 ? -33.064 -26.740 23.209 1.00 16.86 ? 598 LYS A O 1 ATOM 4441 C CB . LYS A 1 572 ? -35.887 -25.319 22.691 1.00 17.59 ? 598 LYS A CB 1 ATOM 4442 C CG . LYS A 1 572 ? -37.368 -25.080 22.918 1.00 18.55 ? 598 LYS A CG 1 ATOM 4443 C CD . LYS A 1 572 ? -37.813 -23.714 22.434 1.00 19.14 ? 598 LYS A CD 1 ATOM 4444 C CE . LYS A 1 572 ? -39.307 -23.701 22.152 1.00 19.59 ? 598 LYS A CE 1 ATOM 4445 N NZ . LYS A 1 572 ? -40.080 -24.119 23.348 1.00 19.89 ? 598 LYS A NZ 1 ATOM 4446 N N . PRO A 1 573 ? -34.020 -27.722 21.416 1.00 16.54 ? 599 PRO A N 1 ATOM 4447 C CA . PRO A 1 573 ? -32.725 -27.976 20.784 1.00 16.37 ? 599 PRO A CA 1 ATOM 4448 C C . PRO A 1 573 ? -31.945 -26.680 20.607 1.00 16.12 ? 599 PRO A C 1 ATOM 4449 O O . PRO A 1 573 ? -32.500 -25.684 20.144 1.00 16.19 ? 599 PRO A O 1 ATOM 4450 C CB . PRO A 1 573 ? -33.101 -28.558 19.421 1.00 16.40 ? 599 PRO A CB 1 ATOM 4451 C CG . PRO A 1 573 ? -34.451 -29.147 19.615 1.00 16.52 ? 599 PRO A CG 1 ATOM 4452 C CD . PRO A 1 573 ? -35.135 -28.321 20.661 1.00 16.56 ? 599 PRO A CD 1 ATOM 4453 N N . SER A 1 574 ? -30.676 -26.681 20.998 1.00 15.68 ? 600 SER A N 1 ATOM 4454 C CA . SER A 1 574 ? -29.859 -25.483 20.866 1.00 15.45 ? 600 SER A CA 1 ATOM 4455 C C . SER A 1 574 ? -28.388 -25.829 20.783 1.00 15.41 ? 600 SER A C 1 ATOM 4456 O O . SER A 1 574 ? -27.907 -26.680 21.526 1.00 15.62 ? 600 SER A O 1 ATOM 4457 C CB . SER A 1 574 ? -30.088 -24.551 22.052 1.00 14.99 ? 600 SER A CB 1 ATOM 4458 O OG . SER A 1 574 ? -29.338 -23.364 21.888 1.00 14.75 ? 600 SER A OG 1 ATOM 4459 N N . THR A 1 575 ? -27.678 -25.154 19.885 1.00 15.38 ? 601 THR A N 1 ATOM 4460 C CA . THR A 1 575 ? -26.228 -25.269 19.808 1.00 15.63 ? 601 THR A CA 1 ATOM 4461 C C . THR A 1 575 ? -25.527 -24.061 20.433 1.00 15.18 ? 601 THR A C 1 ATOM 4462 O O . THR A 1 575 ? -24.298 -24.002 20.449 1.00 15.69 ? 601 THR A O 1 ATOM 4463 C CB . THR A 1 575 ? -25.762 -25.457 18.351 1.00 15.92 ? 601 THR A CB 1 ATOM 4464 O OG1 . THR A 1 575 ? -26.403 -24.490 17.520 1.00 16.26 ? 601 THR A OG1 1 ATOM 4465 C CG2 . THR A 1 575 ? -26.122 -26.857 17.858 1.00 16.18 ? 601 THR A CG2 1 ATOM 4466 N N . PHE A 1 576 ? -26.298 -23.114 20.967 1.00 14.70 ? 602 PHE A N 1 ATOM 4467 C CA . PHE A 1 576 ? -25.722 -21.971 21.676 1.00 14.26 ? 602 PHE A CA 1 ATOM 4468 C C . PHE A 1 576 ? -24.965 -22.491 22.903 1.00 14.36 ? 602 PHE A C 1 ATOM 4469 O O . PHE A 1 576 ? -25.504 -23.289 23.679 1.00 13.97 ? 602 PHE A O 1 ATOM 4470 C CB . PHE A 1 576 ? -26.820 -20.984 22.081 1.00 14.22 ? 602 PHE A CB 1 ATOM 4471 C CG . PHE A 1 576 ? -26.322 -19.590 22.374 1.00 13.97 ? 602 PHE A CG 1 ATOM 4472 C CD1 . PHE A 1 576 ? -25.722 -18.827 21.384 1.00 13.83 ? 602 PHE A CD1 1 ATOM 4473 C CD2 . PHE A 1 576 ? -26.493 -19.029 23.630 1.00 13.92 ? 602 PHE A CD2 1 ATOM 4474 C CE1 . PHE A 1 576 ? -25.281 -17.540 21.648 1.00 13.87 ? 602 PHE A CE1 1 ATOM 4475 C CE2 . PHE A 1 576 ? -26.049 -17.745 23.903 1.00 13.92 ? 602 PHE A CE2 1 ATOM 4476 C CZ . PHE A 1 576 ? -25.443 -17.000 22.912 1.00 13.85 ? 602 PHE A CZ 1 ATOM 4477 N N . ASN A 1 577 ? -23.712 -22.054 23.067 1.00 14.35 ? 603 ASN A N 1 ATOM 4478 C CA . ASN A 1 577 ? -22.821 -22.594 24.109 1.00 14.23 ? 603 ASN A CA 1 ATOM 4479 C C . ASN A 1 577 ? -23.096 -21.993 25.495 1.00 14.19 ? 603 ASN A C 1 ATOM 4480 O O . ASN A 1 577 ? -22.176 -21.688 26.254 1.00 14.46 ? 603 ASN A O 1 ATOM 4481 C CB . ASN A 1 577 ? -21.350 -22.353 23.741 1.00 14.33 ? 603 ASN A CB 1 ATOM 4482 C CG . ASN A 1 577 ? -20.917 -23.066 22.466 1.00 14.64 ? 603 ASN A CG 1 ATOM 4483 O OD1 . ASN A 1 577 ? -21.667 -23.822 21.852 1.00 15.48 ? 603 ASN A OD1 1 ATOM 4484 N ND2 . ASN A 1 577 ? -19.685 -22.825 22.073 1.00 14.77 ? 603 ASN A ND2 1 ATOM 4485 N N . LEU A 1 578 ? -24.369 -21.846 25.828 1.00 13.96 ? 604 LEU A N 1 ATOM 4486 C CA . LEU A 1 578 ? -24.777 -21.163 27.040 1.00 13.87 ? 604 LEU A CA 1 ATOM 4487 C C . LEU A 1 578 ? -26.240 -21.492 27.285 1.00 13.81 ? 604 LEU A C 1 ATOM 4488 O O . LEU A 1 578 ? -27.024 -21.579 26.338 1.00 13.49 ? 604 LEU A O 1 ATOM 4489 C CB . LEU A 1 578 ? -24.584 -19.654 26.872 1.00 13.98 ? 604 LEU A CB 1 ATOM 4490 C CG . LEU A 1 578 ? -25.085 -18.682 27.944 1.00 13.97 ? 604 LEU A CG 1 ATOM 4491 C CD1 . LEU A 1 578 ? -24.267 -17.397 27.888 1.00 13.83 ? 604 LEU A CD1 1 ATOM 4492 C CD2 . LEU A 1 578 ? -26.568 -18.376 27.789 1.00 13.86 ? 604 LEU A CD2 1 ATOM 4493 N N . PHE A 1 579 ? -26.609 -21.669 28.547 1.00 13.74 ? 605 PHE A N 1 ATOM 4494 C CA . PHE A 1 579 ? -27.996 -21.939 28.899 1.00 13.77 ? 605 PHE A CA 1 ATOM 4495 C C . PHE A 1 579 ? -28.296 -21.420 30.289 1.00 13.57 ? 605 PHE A C 1 ATOM 4496 O O . PHE A 1 579 ? -27.562 -21.717 31.238 1.00 13.34 ? 605 PHE A O 1 ATOM 4497 C CB . PHE A 1 579 ? -28.267 -23.441 28.832 1.00 14.11 ? 605 PHE A CB 1 ATOM 4498 C CG . PHE A 1 579 ? -29.678 -23.825 29.186 1.00 14.63 ? 605 PHE A CG 1 ATOM 4499 C CD1 . PHE A 1 579 ? -30.735 -23.482 28.349 1.00 14.81 ? 605 PHE A CD1 1 ATOM 4500 C CD2 . PHE A 1 579 ? -29.952 -24.541 30.347 1.00 14.74 ? 605 PHE A CD2 1 ATOM 4501 C CE1 . PHE A 1 579 ? -32.039 -23.845 28.663 1.00 14.96 ? 605 PHE A CE1 1 ATOM 4502 C CE2 . PHE A 1 579 ? -31.254 -24.904 30.664 1.00 14.89 ? 605 PHE A CE2 1 ATOM 4503 C CZ . PHE A 1 579 ? -32.296 -24.558 29.819 1.00 14.85 ? 605 PHE A CZ 1 ATOM 4504 N N . VAL A 1 580 ? -29.367 -20.637 30.402 1.00 13.57 ? 606 VAL A N 1 ATOM 4505 C CA . VAL A 1 580 ? -29.859 -20.191 31.699 1.00 13.53 ? 606 VAL A CA 1 ATOM 4506 C C . VAL A 1 580 ? -30.740 -21.295 32.278 1.00 13.29 ? 606 VAL A C 1 ATOM 4507 O O . VAL A 1 580 ? -31.742 -21.671 31.671 1.00 13.30 ? 606 VAL A O 1 ATOM 4508 C CB . VAL A 1 580 ? -30.668 -18.877 31.598 1.00 13.66 ? 606 VAL A CB 1 ATOM 4509 C CG1 . VAL A 1 580 ? -31.317 -18.543 32.937 1.00 13.75 ? 606 VAL A CG1 1 ATOM 4510 C CG2 . VAL A 1 580 ? -29.770 -17.735 31.151 1.00 13.75 ? 606 VAL A CG2 1 ATOM 4511 N N . PHE A 1 581 ? -30.359 -21.809 33.445 1.00 13.27 ? 607 PHE A N 1 ATOM 4512 C CA . PHE A 1 581 ? -31.127 -22.842 34.135 1.00 13.18 ? 607 PHE A CA 1 ATOM 4513 C C . PHE A 1 581 ? -31.941 -22.196 35.245 1.00 13.51 ? 607 PHE A C 1 ATOM 4514 O O . PHE A 1 581 ? -31.382 -21.711 36.234 1.00 13.23 ? 607 PHE A O 1 ATOM 4515 C CB . PHE A 1 581 ? -30.198 -23.925 34.696 1.00 13.02 ? 607 PHE A CB 1 ATOM 4516 C CG . PHE A 1 581 ? -30.916 -25.109 35.299 1.00 12.94 ? 607 PHE A CG 1 ATOM 4517 C CD1 . PHE A 1 581 ? -32.020 -25.685 34.669 1.00 12.94 ? 607 PHE A CD1 1 ATOM 4518 C CD2 . PHE A 1 581 ? -30.469 -25.669 36.487 1.00 12.97 ? 607 PHE A CD2 1 ATOM 4519 C CE1 . PHE A 1 581 ? -32.666 -26.777 35.224 1.00 12.89 ? 607 PHE A CE1 1 ATOM 4520 C CE2 . PHE A 1 581 ? -31.110 -26.765 37.045 1.00 12.91 ? 607 PHE A CE2 1 ATOM 4521 C CZ . PHE A 1 581 ? -32.208 -27.319 36.415 1.00 12.90 ? 607 PHE A CZ 1 ATOM 4522 N N . SER A 1 582 ? -33.259 -22.175 35.056 1.00 13.96 ? 608 SER A N 1 ATOM 4523 C CA . SER A 1 582 ? -34.193 -21.612 36.028 1.00 14.51 ? 608 SER A CA 1 ATOM 4524 C C . SER A 1 582 ? -35.331 -22.601 36.279 1.00 15.12 ? 608 SER A C 1 ATOM 4525 O O . SER A 1 582 ? -36.436 -22.415 35.773 1.00 14.78 ? 608 SER A O 1 ATOM 4526 C CB . SER A 1 582 ? -34.747 -20.281 35.507 1.00 14.53 ? 608 SER A CB 1 ATOM 4527 O OG . SER A 1 582 ? -35.705 -19.725 36.395 1.00 14.29 ? 608 SER A OG 1 ATOM 4528 N N . PRO A 1 583 ? -35.066 -23.662 37.061 1.00 16.34 ? 609 PRO A N 1 ATOM 4529 C CA . PRO A 1 583 ? -36.099 -24.673 37.307 1.00 17.18 ? 609 PRO A CA 1 ATOM 4530 C C . PRO A 1 583 ? -37.206 -24.149 38.223 1.00 18.59 ? 609 PRO A C 1 ATOM 4531 O O . PRO A 1 583 ? -36.918 -23.415 39.166 1.00 18.37 ? 609 PRO A O 1 ATOM 4532 C CB . PRO A 1 583 ? -35.323 -25.799 37.988 1.00 16.83 ? 609 PRO A CB 1 ATOM 4533 C CG . PRO A 1 583 ? -34.224 -25.091 38.709 1.00 16.82 ? 609 PRO A CG 1 ATOM 4534 C CD . PRO A 1 583 ? -33.841 -23.930 37.835 1.00 16.44 ? 609 PRO A CD 1 ATOM 4535 N N . ASP A 1 584 ? -38.451 -24.535 37.937 1.00 20.61 ? 610 ASP A N 1 ATOM 4536 C CA . ASP A 1 584 ? -39.629 -24.140 38.738 1.00 22.50 ? 610 ASP A CA 1 ATOM 4537 C C . ASP A 1 584 ? -39.443 -24.412 40.219 1.00 22.38 ? 610 ASP A C 1 ATOM 4538 O O . ASP A 1 584 ? -39.968 -23.695 41.059 1.00 23.27 ? 610 ASP A O 1 ATOM 4539 C CB . ASP A 1 584 ? -40.880 -24.918 38.304 1.00 23.90 ? 610 ASP A CB 1 ATOM 4540 C CG . ASP A 1 584 ? -41.129 -24.845 36.827 1.00 25.59 ? 610 ASP A CG 1 ATOM 4541 O OD1 . ASP A 1 584 ? -40.289 -24.252 36.117 1.00 27.90 ? 610 ASP A OD1 1 ATOM 4542 O OD2 . ASP A 1 584 ? -42.150 -25.399 36.369 1.00 26.89 ? 610 ASP A OD2 1 ATOM 4543 N N . THR A 1 585 ? -38.717 -25.478 40.523 1.00 22.83 ? 611 THR A N 1 ATOM 4544 C CA . THR A 1 585 ? -38.505 -25.924 41.899 1.00 22.57 ? 611 THR A CA 1 ATOM 4545 C C . THR A 1 585 ? -37.505 -25.059 42.667 1.00 22.00 ? 611 THR A C 1 ATOM 4546 O O . THR A 1 585 ? -37.474 -25.099 43.893 1.00 22.55 ? 611 THR A O 1 ATOM 4547 C CB . THR A 1 585 ? -37.991 -27.374 41.906 1.00 22.90 ? 611 THR A CB 1 ATOM 4548 O OG1 . THR A 1 585 ? -36.786 -27.455 41.133 1.00 23.10 ? 611 THR A OG1 1 ATOM 4549 C CG2 . THR A 1 585 ? -39.034 -28.312 41.307 1.00 22.92 ? 611 THR A CG2 1 ATOM 4550 N N . GLY A 1 586 ? -36.682 -24.293 41.949 1.00 21.16 ? 612 GLY A N 1 ATOM 4551 C CA . GLY A 1 586 ? -35.588 -23.542 42.564 1.00 20.36 ? 612 GLY A CA 1 ATOM 4552 C C . GLY A 1 586 ? -34.395 -24.399 42.970 1.00 19.67 ? 612 GLY A C 1 ATOM 4553 O O . GLY A 1 586 ? -33.447 -23.899 43.564 1.00 19.72 ? 612 GLY A O 1 ATOM 4554 N N . ALA A 1 587 ? -34.431 -25.688 42.651 1.00 19.05 ? 613 ALA A N 1 ATOM 4555 C CA . ALA A 1 587 ? -33.365 -26.607 43.032 1.00 18.84 ? 613 ALA A CA 1 ATOM 4556 C C . ALA A 1 587 ? -32.239 -26.558 41.998 1.00 18.56 ? 613 ALA A C 1 ATOM 4557 O O . ALA A 1 587 ? -32.326 -27.187 40.942 1.00 18.29 ? 613 ALA A O 1 ATOM 4558 C CB . ALA A 1 587 ? -33.914 -28.021 43.166 1.00 18.90 ? 613 ALA A CB 1 ATOM 4559 N N . VAL A 1 588 ? -31.195 -25.788 42.302 1.00 18.28 ? 614 VAL A N 1 ATOM 4560 C CA . VAL A 1 588 ? -30.044 -25.641 41.408 1.00 18.37 ? 614 VAL A CA 1 ATOM 4561 C C . VAL A 1 588 ? -28.719 -26.142 41.999 1.00 18.31 ? 614 VAL A C 1 ATOM 4562 O O . VAL A 1 588 ? -27.750 -26.340 41.255 1.00 17.84 ? 614 VAL A O 1 ATOM 4563 C CB . VAL A 1 588 ? -29.853 -24.175 40.964 1.00 18.55 ? 614 VAL A CB 1 ATOM 4564 C CG1 . VAL A 1 588 ? -31.086 -23.685 40.221 1.00 18.63 ? 614 VAL A CG1 1 ATOM 4565 C CG2 . VAL A 1 588 ? -29.536 -23.273 42.152 1.00 18.68 ? 614 VAL A CG2 1 ATOM 4566 N N . SER A 1 589 ? -28.676 -26.335 43.319 1.00 17.90 ? 615 SER A N 1 ATOM 4567 C CA . SER A 1 589 ? -27.454 -26.746 43.998 1.00 17.82 ? 615 SER A CA 1 ATOM 4568 C C . SER A 1 589 ? -27.149 -28.220 43.738 1.00 17.46 ? 615 SER A C 1 ATOM 4569 O O . SER A 1 589 ? -27.998 -29.073 43.931 1.00 18.44 ? 615 SER A O 1 ATOM 4570 C CB . SER A 1 589 ? -27.546 -26.478 45.502 1.00 17.82 ? 615 SER A CB 1 ATOM 4571 O OG . SER A 1 589 ? -27.310 -25.107 45.784 1.00 18.07 ? 615 SER A OG 1 ATOM 4572 N N . GLY A 1 590 ? -25.929 -28.503 43.299 1.00 17.02 ? 616 GLY A N 1 ATOM 4573 C CA . GLY A 1 590 ? -25.517 -29.857 42.941 1.00 16.73 ? 616 GLY A CA 1 ATOM 4574 C C . GLY A 1 590 ? -24.374 -29.815 41.944 1.00 16.36 ? 616 GLY A C 1 ATOM 4575 O O . GLY A 1 590 ? -23.501 -28.948 42.032 1.00 16.44 ? 616 GLY A O 1 ATOM 4576 N N . SER A 1 591 ? -24.377 -30.745 40.995 1.00 15.96 ? 617 SER A N 1 ATOM 4577 C CA . SER A 1 591 ? -23.332 -30.805 39.978 1.00 16.10 ? 617 SER A CA 1 ATOM 4578 C C . SER A 1 591 ? -23.922 -30.873 38.579 1.00 15.30 ? 617 SER A C 1 ATOM 4579 O O . SER A 1 591 ? -24.982 -31.467 38.373 1.00 15.03 ? 617 SER A O 1 ATOM 4580 C CB . SER A 1 591 ? -22.409 -32.006 40.211 1.00 16.65 ? 617 SER A CB 1 ATOM 4581 O OG . SER A 1 591 ? -21.481 -31.724 41.246 1.00 17.86 ? 617 SER A OG 1 ATOM 4582 N N . TYR A 1 592 ? -23.206 -30.284 37.620 1.00 14.52 ? 618 TYR A N 1 ATOM 4583 C CA . TYR A 1 592 ? -23.661 -30.218 36.234 1.00 13.90 ? 618 TYR A CA 1 ATOM 4584 C C . TYR A 1 592 ? -22.606 -30.770 35.286 1.00 13.35 ? 618 TYR A C 1 ATOM 4585 O O . TYR A 1 592 ? -21.415 -30.650 35.536 1.00 13.22 ? 618 TYR A O 1 ATOM 4586 C CB . TYR A 1 592 ? -23.968 -28.770 35.838 1.00 13.70 ? 618 TYR A CB 1 ATOM 4587 C CG . TYR A 1 592 ? -25.081 -28.120 36.621 1.00 13.57 ? 618 TYR A CG 1 ATOM 4588 C CD1 . TYR A 1 592 ? -24.836 -27.514 37.844 1.00 13.40 ? 618 TYR A CD1 1 ATOM 4589 C CD2 . TYR A 1 592 ? -26.384 -28.096 36.124 1.00 13.55 ? 618 TYR A CD2 1 ATOM 4590 C CE1 . TYR A 1 592 ? -25.856 -26.913 38.561 1.00 13.46 ? 618 TYR A CE1 1 ATOM 4591 C CE2 . TYR A 1 592 ? -27.407 -27.493 36.827 1.00 13.45 ? 618 TYR A CE2 1 ATOM 4592 C CZ . TYR A 1 592 ? -27.144 -26.905 38.044 1.00 13.53 ? 618 TYR A CZ 1 ATOM 4593 O OH . TYR A 1 592 ? -28.171 -26.306 38.743 1.00 13.73 ? 618 TYR A OH 1 ATOM 4594 N N . ARG A 1 593 ? -23.059 -31.368 34.192 1.00 12.82 ? 619 ARG A N 1 ATOM 4595 C CA . ARG A 1 593 ? -22.171 -31.796 33.121 1.00 12.41 ? 619 ARG A CA 1 ATOM 4596 C C . ARG A 1 593 ? -22.910 -31.673 31.799 1.00 12.17 ? 619 ARG A C 1 ATOM 4597 O O . ARG A 1 593 ? -24.138 -31.766 31.752 1.00 11.92 ? 619 ARG A O 1 ATOM 4598 C CB . ARG A 1 593 ? -21.684 -33.231 33.347 1.00 12.38 ? 619 ARG A CB 1 ATOM 4599 C CG . ARG A 1 593 ? -22.782 -34.283 33.395 1.00 12.35 ? 619 ARG A CG 1 ATOM 4600 C CD . ARG A 1 593 ? -22.238 -35.645 33.816 1.00 12.29 ? 619 ARG A CD 1 ATOM 4601 N NE . ARG A 1 593 ? -23.186 -36.718 33.510 1.00 12.19 ? 619 ARG A NE 1 ATOM 4602 C CZ . ARG A 1 593 ? -23.004 -38.006 33.800 1.00 12.14 ? 619 ARG A CZ 1 ATOM 4603 N NH1 . ARG A 1 593 ? -21.904 -38.419 34.413 1.00 12.14 ? 619 ARG A NH1 1 ATOM 4604 N NH2 . ARG A 1 593 ? -23.938 -38.891 33.483 1.00 12.16 ? 619 ARG A NH2 1 ATOM 4605 N N . VAL A 1 594 ? -22.152 -31.459 30.728 1.00 11.94 ? 620 VAL A N 1 ATOM 4606 C CA . VAL A 1 594 ? -22.722 -31.209 29.410 1.00 11.78 ? 620 VAL A CA 1 ATOM 4607 C C . VAL A 1 594 ? -21.977 -31.996 28.333 1.00 11.44 ? 620 VAL A C 1 ATOM 4608 O O . VAL A 1 594 ? -20.769 -32.195 28.429 1.00 11.23 ? 620 VAL A O 1 ATOM 4609 C CB . VAL A 1 594 ? -22.654 -29.702 29.072 1.00 11.84 ? 620 VAL A CB 1 ATOM 4610 C CG1 . VAL A 1 594 ? -23.258 -29.410 27.705 1.00 12.00 ? 620 VAL A CG1 1 ATOM 4611 C CG2 . VAL A 1 594 ? -23.354 -28.890 30.143 1.00 11.93 ? 620 VAL A CG2 1 ATOM 4612 N N . ARG A 1 595 ? -22.706 -32.436 27.311 1.00 11.40 ? 621 ARG A N 1 ATOM 4613 C CA . ARG A 1 595 ? -22.097 -33.089 26.152 1.00 11.50 ? 621 ARG A CA 1 ATOM 4614 C C . ARG A 1 595 ? -22.797 -32.735 24.844 1.00 11.67 ? 621 ARG A C 1 ATOM 4615 O O . ARG A 1 595 ? -23.968 -32.352 24.828 1.00 11.56 ? 621 ARG A O 1 ATOM 4616 C CB . ARG A 1 595 ? -22.084 -34.607 26.330 1.00 11.40 ? 621 ARG A CB 1 ATOM 4617 C CG . ARG A 1 595 ? -23.451 -35.265 26.354 1.00 11.38 ? 621 ARG A CG 1 ATOM 4618 C CD . ARG A 1 595 ? -23.302 -36.756 26.603 1.00 11.30 ? 621 ARG A CD 1 ATOM 4619 N NE . ARG A 1 595 ? -24.582 -37.444 26.729 1.00 11.23 ? 621 ARG A NE 1 ATOM 4620 C CZ . ARG A 1 595 ? -24.717 -38.765 26.838 1.00 11.33 ? 621 ARG A CZ 1 ATOM 4621 N NH1 . ARG A 1 595 ? -23.647 -39.556 26.840 1.00 11.34 ? 621 ARG A NH1 1 ATOM 4622 N NH2 . ARG A 1 595 ? -25.926 -39.302 26.947 1.00 11.22 ? 621 ARG A NH2 1 ATOM 4623 N N . ALA A 1 596 ? -22.063 -32.881 23.749 1.00 11.98 ? 622 ALA A N 1 ATOM 4624 C CA . ALA A 1 596 ? -22.610 -32.688 22.411 1.00 12.36 ? 622 ALA A CA 1 ATOM 4625 C C . ALA A 1 596 ? -23.425 -33.915 21.990 1.00 12.44 ? 622 ALA A C 1 ATOM 4626 O O . ALA A 1 596 ? -23.071 -35.039 22.328 1.00 12.63 ? 622 ALA A O 1 ATOM 4627 C CB . ALA A 1 596 ? -21.483 -32.443 21.423 1.00 12.35 ? 622 ALA A CB 1 ATOM 4628 N N . LEU A 1 597 ? -24.527 -33.683 21.284 1.00 12.79 ? 623 LEU A N 1 ATOM 4629 C CA . LEU A 1 597 ? -25.315 -34.752 20.660 1.00 12.93 ? 623 LEU A CA 1 ATOM 4630 C C . LEU A 1 597 ? -25.434 -34.458 19.172 1.00 12.87 ? 623 LEU A C 1 ATOM 4631 O O . LEU A 1 597 ? -25.930 -33.391 18.796 1.00 12.57 ? 623 LEU A O 1 ATOM 4632 C CB . LEU A 1 597 ? -26.718 -34.826 21.254 1.00 13.14 ? 623 LEU A CB 1 ATOM 4633 C CG . LEU A 1 597 ? -26.890 -35.127 22.742 1.00 13.40 ? 623 LEU A CG 1 ATOM 4634 C CD1 . LEU A 1 597 ? -28.374 -35.318 23.037 1.00 13.47 ? 623 LEU A CD1 1 ATOM 4635 C CD2 . LEU A 1 597 ? -26.094 -36.352 23.170 1.00 13.50 ? 623 LEU A CD2 1 ATOM 4636 N N . ASP A 1 598 ? -24.983 -35.389 18.327 1.00 12.93 ? 624 ASP A N 1 ATOM 4637 C CA . ASP A 1 598 ? -24.989 -35.156 16.875 1.00 13.07 ? 624 ASP A CA 1 ATOM 4638 C C . ASP A 1 598 ? -26.323 -35.550 16.244 1.00 13.24 ? 624 ASP A C 1 ATOM 4639 O O . ASP A 1 598 ? -27.233 -35.992 16.935 1.00 13.06 ? 624 ASP A O 1 ATOM 4640 C CB . ASP A 1 598 ? -23.789 -35.829 16.179 1.00 13.15 ? 624 ASP A CB 1 ATOM 4641 C CG . ASP A 1 598 ? -23.845 -37.351 16.197 1.00 13.37 ? 624 ASP A CG 1 ATOM 4642 O OD1 . ASP A 1 598 ? -24.926 -37.946 16.380 1.00 13.24 ? 624 ASP A OD1 1 ATOM 4643 O OD2 . ASP A 1 598 ? -22.775 -37.963 16.003 1.00 14.05 ? 624 ASP A OD2 1 ATOM 4644 N N . TYR A 1 599 ? -26.436 -35.396 14.929 1.00 13.73 ? 625 TYR A N 1 ATOM 4645 C CA . TYR A 1 599 ? -27.696 -35.668 14.235 1.00 14.00 ? 625 TYR A CA 1 ATOM 4646 C C . TYR A 1 599 ? -28.085 -37.151 14.230 1.00 14.51 ? 625 TYR A C 1 ATOM 4647 O O . TYR A 1 599 ? -29.223 -37.477 13.924 1.00 14.58 ? 625 TYR A O 1 ATOM 4648 C CB . TYR A 1 599 ? -27.641 -35.147 12.797 1.00 13.81 ? 625 TYR A CB 1 ATOM 4649 C CG . TYR A 1 599 ? -27.572 -33.641 12.644 1.00 13.63 ? 625 TYR A CG 1 ATOM 4650 C CD1 . TYR A 1 599 ? -28.112 -32.779 13.602 1.00 13.59 ? 625 TYR A CD1 1 ATOM 4651 C CD2 . TYR A 1 599 ? -27.006 -33.073 11.508 1.00 13.52 ? 625 TYR A CD2 1 ATOM 4652 C CE1 . TYR A 1 599 ? -28.059 -31.401 13.438 1.00 13.45 ? 625 TYR A CE1 1 ATOM 4653 C CE2 . TYR A 1 599 ? -26.959 -31.696 11.336 1.00 13.41 ? 625 TYR A CE2 1 ATOM 4654 C CZ . TYR A 1 599 ? -27.489 -30.869 12.303 1.00 13.24 ? 625 TYR A CZ 1 ATOM 4655 O OH . TYR A 1 599 ? -27.431 -29.509 12.139 1.00 13.18 ? 625 TYR A OH 1 ATOM 4656 N N . TRP A 1 600 ? -27.150 -38.035 14.574 1.00 14.98 ? 626 TRP A N 1 ATOM 4657 C CA . TRP A 1 600 ? -27.417 -39.477 14.633 1.00 15.31 ? 626 TRP A CA 1 ATOM 4658 C C . TRP A 1 600 ? -27.576 -39.963 16.075 1.00 15.26 ? 626 TRP A C 1 ATOM 4659 O O . TRP A 1 600 ? -27.418 -41.147 16.350 1.00 15.35 ? 626 TRP A O 1 ATOM 4660 C CB . TRP A 1 600 ? -26.302 -40.236 13.898 1.00 15.39 ? 626 TRP A CB 1 ATOM 4661 C CG . TRP A 1 600 ? -26.195 -39.746 12.493 1.00 15.60 ? 626 TRP A CG 1 ATOM 4662 C CD1 . TRP A 1 600 ? -26.865 -40.227 11.405 1.00 15.54 ? 626 TRP A CD1 1 ATOM 4663 C CD2 . TRP A 1 600 ? -25.432 -38.625 12.032 1.00 15.68 ? 626 TRP A CD2 1 ATOM 4664 N NE1 . TRP A 1 600 ? -26.545 -39.491 10.291 1.00 15.82 ? 626 TRP A NE1 1 ATOM 4665 C CE2 . TRP A 1 600 ? -25.670 -38.499 10.648 1.00 15.81 ? 626 TRP A CE2 1 ATOM 4666 C CE3 . TRP A 1 600 ? -24.561 -37.725 12.651 1.00 15.96 ? 626 TRP A CE3 1 ATOM 4667 C CZ2 . TRP A 1 600 ? -25.066 -37.508 9.874 1.00 15.87 ? 626 TRP A CZ2 1 ATOM 4668 C CZ3 . TRP A 1 600 ? -23.965 -36.737 11.883 1.00 15.94 ? 626 TRP A CZ3 1 ATOM 4669 C CH2 . TRP A 1 600 ? -24.222 -36.635 10.509 1.00 15.91 ? 626 TRP A CH2 1 ATOM 4670 N N . ALA A 1 601 ? -27.899 -39.031 16.976 1.00 15.16 ? 627 ALA A N 1 ATOM 4671 C CA . ALA A 1 601 ? -28.143 -39.313 18.393 1.00 15.15 ? 627 ALA A CA 1 ATOM 4672 C C . ALA A 1 601 ? -26.914 -39.817 19.166 1.00 14.92 ? 627 ALA A C 1 ATOM 4673 O O . ALA A 1 601 ? -27.049 -40.305 20.284 1.00 14.56 ? 627 ALA A O 1 ATOM 4674 C CB . ALA A 1 601 ? -29.311 -40.289 18.550 1.00 15.26 ? 627 ALA A CB 1 ATOM 4675 N N . ARG A 1 602 ? -25.725 -39.689 18.582 1.00 15.00 ? 628 ARG A N 1 ATOM 4676 C CA . ARG A 1 602 ? -24.505 -40.131 19.249 1.00 15.17 ? 628 ARG A CA 1 ATOM 4677 C C . ARG A 1 602 ? -23.992 -39.016 20.142 1.00 14.73 ? 628 ARG A C 1 ATOM 4678 O O . ARG A 1 602 ? -23.961 -37.858 19.726 1.00 14.75 ? 628 ARG A O 1 ATOM 4679 C CB . ARG A 1 602 ? -23.420 -40.512 18.245 1.00 15.49 ? 628 ARG A CB 1 ATOM 4680 C CG . ARG A 1 602 ? -23.804 -41.612 17.273 1.00 15.76 ? 628 ARG A CG 1 ATOM 4681 C CD . ARG A 1 602 ? -22.645 -41.910 16.329 1.00 16.15 ? 628 ARG A CD 1 ATOM 4682 N NE . ARG A 1 602 ? -22.272 -40.744 15.519 1.00 16.61 ? 628 ARG A NE 1 ATOM 4683 C CZ . ARG A 1 602 ? -21.296 -40.735 14.609 1.00 16.83 ? 628 ARG A CZ 1 ATOM 4684 N NH1 . ARG A 1 602 ? -20.571 -41.822 14.366 1.00 16.90 ? 628 ARG A NH1 1 ATOM 4685 N NH2 . ARG A 1 602 ? -21.047 -39.631 13.923 1.00 16.83 ? 628 ARG A NH2 1 ATOM 4686 N N . PRO A 1 603 ? -23.599 -39.354 21.377 1.00 14.57 ? 629 PRO A N 1 ATOM 4687 C CA . PRO A 1 603 ? -23.050 -38.338 22.255 1.00 14.43 ? 629 PRO A CA 1 ATOM 4688 C C . PRO A 1 603 ? -21.541 -38.201 22.111 1.00 14.33 ? 629 PRO A C 1 ATOM 4689 O O . PRO A 1 603 ? -20.866 -39.149 21.721 1.00 14.04 ? 629 PRO A O 1 ATOM 4690 C CB . PRO A 1 603 ? -23.405 -38.859 23.641 1.00 14.57 ? 629 PRO A CB 1 ATOM 4691 C CG . PRO A 1 603 ? -23.421 -40.343 23.496 1.00 14.76 ? 629 PRO A CG 1 ATOM 4692 C CD . PRO A 1 603 ? -23.799 -40.639 22.074 1.00 14.71 ? 629 PRO A CD 1 ATOM 4693 N N . GLY A 1 604 ? -21.023 -37.013 22.413 1.00 14.32 ? 630 GLY A N 1 ATOM 4694 C CA . GLY A 1 604 ? -19.590 -36.844 22.654 1.00 14.19 ? 630 GLY A CA 1 ATOM 4695 C C . GLY A 1 604 ? -19.337 -37.144 24.120 1.00 14.28 ? 630 GLY A C 1 ATOM 4696 O O . GLY A 1 604 ? -20.290 -37.384 24.868 1.00 14.16 ? 630 GLY A O 1 ATOM 4697 N N . PRO A 1 605 ? -18.057 -37.141 24.546 1.00 14.08 ? 631 PRO A N 1 ATOM 4698 C CA . PRO A 1 605 ? -17.780 -37.356 25.964 1.00 13.89 ? 631 PRO A CA 1 ATOM 4699 C C . PRO A 1 605 ? -18.298 -36.204 26.819 1.00 13.87 ? 631 PRO A C 1 ATOM 4700 O O . PRO A 1 605 ? -18.270 -35.044 26.387 1.00 14.02 ? 631 PRO A O 1 ATOM 4701 C CB . PRO A 1 605 ? -16.244 -37.423 26.028 1.00 14.05 ? 631 PRO A CB 1 ATOM 4702 C CG . PRO A 1 605 ? -15.799 -37.742 24.639 1.00 14.10 ? 631 PRO A CG 1 ATOM 4703 C CD . PRO A 1 605 ? -16.824 -37.116 23.733 1.00 14.19 ? 631 PRO A CD 1 ATOM 4704 N N . PHE A 1 606 ? -18.766 -36.518 28.020 1.00 13.44 ? 632 PHE A N 1 ATOM 4705 C CA . PHE A 1 606 ? -19.189 -35.482 28.952 1.00 13.51 ? 632 PHE A CA 1 ATOM 4706 C C . PHE A 1 606 ? -18.031 -34.576 29.343 1.00 13.71 ? 632 PHE A C 1 ATOM 4707 O O . PHE A 1 606 ? -16.874 -34.997 29.373 1.00 13.92 ? 632 PHE A O 1 ATOM 4708 C CB . PHE A 1 606 ? -19.775 -36.087 30.225 1.00 13.26 ? 632 PHE A CB 1 ATOM 4709 C CG . PHE A 1 606 ? -21.224 -36.457 30.116 1.00 13.17 ? 632 PHE A CG 1 ATOM 4710 C CD1 . PHE A 1 606 ? -22.198 -35.473 30.010 1.00 13.15 ? 632 PHE A CD1 1 ATOM 4711 C CD2 . PHE A 1 606 ? -21.617 -37.786 30.158 1.00 13.17 ? 632 PHE A CD2 1 ATOM 4712 C CE1 . PHE A 1 606 ? -23.542 -35.814 29.923 1.00 13.31 ? 632 PHE A CE1 1 ATOM 4713 C CE2 . PHE A 1 606 ? -22.958 -38.133 30.086 1.00 13.35 ? 632 PHE A CE2 1 ATOM 4714 C CZ . PHE A 1 606 ? -23.922 -37.146 29.963 1.00 13.25 ? 632 PHE A CZ 1 ATOM 4715 N N . SER A 1 607 ? -18.353 -33.327 29.642 1.00 13.92 ? 633 SER A N 1 ATOM 4716 C CA . SER A 1 607 ? -17.409 -32.440 30.293 1.00 14.15 ? 633 SER A CA 1 ATOM 4717 C C . SER A 1 607 ? -17.121 -32.992 31.687 1.00 14.95 ? 633 SER A C 1 ATOM 4718 O O . SER A 1 607 ? -17.839 -33.870 32.178 1.00 14.94 ? 633 SER A O 1 ATOM 4719 C CB . SER A 1 607 ? -18.019 -31.054 30.429 1.00 13.96 ? 633 SER A CB 1 ATOM 4720 O OG . SER A 1 607 ? -19.201 -31.121 31.210 1.00 13.96 ? 633 SER A OG 1 ATOM 4721 N N . ASP A 1 608 ? -16.092 -32.464 32.336 1.00 15.83 ? 634 ASP A N 1 ATOM 4722 C CA . ASP A 1 608 ? -15.918 -32.705 33.761 1.00 16.85 ? 634 ASP A CA 1 ATOM 4723 C C . ASP A 1 608 ? -17.133 -32.144 34.494 1.00 16.83 ? 634 ASP A C 1 ATOM 4724 O O . ASP A 1 608 ? -17.701 -31.133 34.069 1.00 16.61 ? 634 ASP A O 1 ATOM 4725 C CB . ASP A 1 608 ? -14.651 -32.031 34.284 1.00 17.51 ? 634 ASP A CB 1 ATOM 4726 C CG . ASP A 1 608 ? -13.395 -32.563 33.623 1.00 18.08 ? 634 ASP A CG 1 ATOM 4727 O OD1 . ASP A 1 608 ? -12.983 -33.689 33.943 1.00 18.61 ? 634 ASP A OD1 1 ATOM 4728 O OD2 . ASP A 1 608 ? -12.820 -31.852 32.783 1.00 19.13 ? 634 ASP A OD2 1 ATOM 4729 N N . PRO A 1 609 ? -17.547 -32.803 35.587 1.00 16.87 ? 635 PRO A N 1 ATOM 4730 C CA . PRO A 1 609 ? -18.662 -32.253 36.354 1.00 16.96 ? 635 PRO A CA 1 ATOM 4731 C C . PRO A 1 609 ? -18.282 -30.941 37.034 1.00 16.96 ? 635 PRO A C 1 ATOM 4732 O O . PRO A 1 609 ? -17.145 -30.780 37.477 1.00 16.67 ? 635 PRO A O 1 ATOM 4733 C CB . PRO A 1 609 ? -18.973 -33.347 37.383 1.00 16.73 ? 635 PRO A CB 1 ATOM 4734 C CG . PRO A 1 609 ? -17.744 -34.184 37.461 1.00 16.83 ? 635 PRO A CG 1 ATOM 4735 C CD . PRO A 1 609 ? -17.045 -34.073 36.142 1.00 16.89 ? 635 PRO A CD 1 ATOM 4736 N N . VAL A 1 610 ? -19.227 -30.010 37.097 1.00 17.08 ? 636 VAL A N 1 ATOM 4737 C CA . VAL A 1 610 ? -19.001 -28.741 37.772 1.00 17.65 ? 636 VAL A CA 1 ATOM 4738 C C . VAL A 1 610 ? -19.976 -28.594 38.928 1.00 17.88 ? 636 VAL A C 1 ATOM 4739 O O . VAL A 1 610 ? -21.185 -28.631 38.713 1.00 17.71 ? 636 VAL A O 1 ATOM 4740 C CB . VAL A 1 610 ? -19.152 -27.555 36.807 1.00 17.67 ? 636 VAL A CB 1 ATOM 4741 C CG1 . VAL A 1 610 ? -19.029 -26.234 37.554 1.00 17.95 ? 636 VAL A CG1 1 ATOM 4742 C CG2 . VAL A 1 610 ? -18.103 -27.646 35.709 1.00 17.77 ? 636 VAL A CG2 1 ATOM 4743 N N . PRO A 1 611 ? -19.452 -28.415 40.157 1.00 18.80 ? 637 PRO A N 1 ATOM 4744 C CA . PRO A 1 611 ? -20.312 -28.260 41.325 1.00 19.50 ? 637 PRO A CA 1 ATOM 4745 C C . PRO A 1 611 ? -20.907 -26.867 41.392 1.00 20.12 ? 637 PRO A C 1 ATOM 4746 O O . PRO A 1 611 ? -20.350 -25.932 40.830 1.00 21.14 ? 637 PRO A O 1 ATOM 4747 C CB . PRO A 1 611 ? -19.347 -28.471 42.494 1.00 19.33 ? 637 PRO A CB 1 ATOM 4748 C CG . PRO A 1 611 ? -18.055 -27.927 41.988 1.00 19.15 ? 637 PRO A CG 1 ATOM 4749 C CD . PRO A 1 611 ? -18.027 -28.258 40.513 1.00 19.10 ? 637 PRO A CD 1 ATOM 4750 N N . TYR A 1 612 ? -22.036 -26.737 42.073 1.00 21.18 ? 638 TYR A N 1 ATOM 4751 C CA . TYR A 1 612 ? -22.639 -25.433 42.316 1.00 21.54 ? 638 TYR A CA 1 ATOM 4752 C C . TYR A 1 612 ? -23.398 -25.476 43.634 1.00 22.29 ? 638 TYR A C 1 ATOM 4753 O O . TYR A 1 612 ? -24.176 -26.401 43.873 1.00 22.57 ? 638 TYR A O 1 ATOM 4754 C CB . TYR A 1 612 ? -23.577 -25.056 41.167 1.00 21.11 ? 638 TYR A CB 1 ATOM 4755 C CG . TYR A 1 612 ? -24.170 -23.672 41.292 1.00 20.49 ? 638 TYR A CG 1 ATOM 4756 C CD1 . TYR A 1 612 ? -23.455 -22.551 40.882 1.00 20.25 ? 638 TYR A CD1 1 ATOM 4757 C CD2 . TYR A 1 612 ? -25.443 -23.480 41.827 1.00 20.03 ? 638 TYR A CD2 1 ATOM 4758 C CE1 . TYR A 1 612 ? -23.989 -21.280 40.995 1.00 19.72 ? 638 TYR A CE1 1 ATOM 4759 C CE2 . TYR A 1 612 ? -25.984 -22.211 41.944 1.00 19.88 ? 638 TYR A CE2 1 ATOM 4760 C CZ . TYR A 1 612 ? -25.250 -21.116 41.527 1.00 19.65 ? 638 TYR A CZ 1 ATOM 4761 O OH . TYR A 1 612 ? -25.780 -19.857 41.636 1.00 19.04 ? 638 TYR A OH 1 ATOM 4762 N N . LEU A 1 613 ? -23.153 -24.486 44.488 1.00 23.43 ? 639 LEU A N 1 ATOM 4763 C CA . LEU A 1 613 ? -23.823 -24.382 45.783 1.00 24.66 ? 639 LEU A CA 1 ATOM 4764 C C . LEU A 1 613 ? -24.289 -22.942 45.967 1.00 25.16 ? 639 LEU A C 1 ATOM 4765 O O . LEU A 1 613 ? -23.472 -22.026 45.910 1.00 25.02 ? 639 LEU A O 1 ATOM 4766 C CB . LEU A 1 613 ? -22.858 -24.760 46.911 1.00 25.07 ? 639 LEU A CB 1 ATOM 4767 C CG . LEU A 1 613 ? -23.395 -25.531 48.127 1.00 26.09 ? 639 LEU A CG 1 ATOM 4768 C CD1 . LEU A 1 613 ? -22.437 -25.344 49.301 1.00 26.34 ? 639 LEU A CD1 1 ATOM 4769 C CD2 . LEU A 1 613 ? -24.814 -25.147 48.532 1.00 25.97 ? 639 LEU A CD2 1 ATOM 4770 N N . GLU A 1 614 ? -25.592 -22.743 46.176 1.00 26.07 ? 640 GLU A N 1 ATOM 4771 C CA . GLU A 1 614 ? -26.137 -21.390 46.375 1.00 26.49 ? 640 GLU A CA 1 ATOM 4772 C C . GLU A 1 614 ? -25.712 -20.833 47.730 1.00 26.70 ? 640 GLU A C 1 ATOM 4773 O O . GLU A 1 614 ? -25.693 -21.565 48.723 1.00 28.58 ? 640 GLU A O 1 ATOM 4774 C CB . GLU A 1 614 ? -27.670 -21.382 46.263 1.00 26.15 ? 640 GLU A CB 1 ATOM 4775 C CG . GLU A 1 614 ? -28.189 -21.403 44.834 1.00 26.21 ? 640 GLU A CG 1 ATOM 4776 C CD . GLU A 1 614 ? -29.624 -20.920 44.716 1.00 25.87 ? 640 GLU A CD 1 ATOM 4777 O OE1 . GLU A 1 614 ? -30.479 -21.389 45.491 1.00 26.45 ? 640 GLU A OE1 1 ATOM 4778 O OE2 . GLU A 1 614 ? -29.906 -20.076 43.838 1.00 25.04 ? 640 GLU A OE2 1 HETATM 4779 C C1 . NAG B 2 . ? -3.850 -0.853 40.175 1.00 45.56 ? 901 NAG A C1 1 HETATM 4780 C C2 . NAG B 2 . ? -3.256 -0.951 41.575 1.00 49.91 ? 901 NAG A C2 1 HETATM 4781 C C3 . NAG B 2 . ? -4.137 -1.751 42.526 1.00 50.19 ? 901 NAG A C3 1 HETATM 4782 C C4 . NAG B 2 . ? -5.600 -1.351 42.416 1.00 50.17 ? 901 NAG A C4 1 HETATM 4783 C C5 . NAG B 2 . ? -6.037 -1.364 40.955 1.00 49.23 ? 901 NAG A C5 1 HETATM 4784 C C6 . NAG B 2 . ? -7.520 -1.012 40.797 1.00 49.18 ? 901 NAG A C6 1 HETATM 4785 C C7 . NAG B 2 . ? -0.813 -0.956 41.836 1.00 54.57 ? 901 NAG A C7 1 HETATM 4786 C C8 . NAG B 2 . ? 0.459 -1.747 41.713 1.00 55.23 ? 901 NAG A C8 1 HETATM 4787 N N2 . NAG B 2 . ? -1.947 -1.582 41.508 1.00 52.39 ? 901 NAG A N2 1 HETATM 4788 O O3 . NAG B 2 . ? -3.696 -1.532 43.843 1.00 51.18 ? 901 NAG A O3 1 HETATM 4789 O O4 . NAG B 2 . ? -6.369 -2.266 43.162 1.00 51.08 ? 901 NAG A O4 1 HETATM 4790 O O5 . NAG B 2 . ? -5.215 -0.474 40.219 1.00 47.08 ? 901 NAG A O5 1 HETATM 4791 O O6 . NAG B 2 . ? -7.747 0.371 40.964 1.00 50.18 ? 901 NAG A O6 1 HETATM 4792 O O7 . NAG B 2 . ? -0.763 0.213 42.224 1.00 56.05 ? 901 NAG A O7 1 HETATM 4793 C C1 . NAG C 2 . ? -29.780 -2.218 -6.013 1.00 24.12 ? 902 NAG A C1 1 HETATM 4794 C C2 . NAG C 2 . ? -28.720 -1.570 -6.908 1.00 24.80 ? 902 NAG A C2 1 HETATM 4795 C C3 . NAG C 2 . ? -29.059 -0.124 -7.208 1.00 25.19 ? 902 NAG A C3 1 HETATM 4796 C C4 . NAG C 2 . ? -30.468 -0.020 -7.757 1.00 25.58 ? 902 NAG A C4 1 HETATM 4797 C C5 . NAG C 2 . ? -31.444 -0.705 -6.811 1.00 25.78 ? 902 NAG A C5 1 HETATM 4798 C C6 . NAG C 2 . ? -32.861 -0.697 -7.368 1.00 25.72 ? 902 NAG A C6 1 HETATM 4799 C C7 . NAG C 2 . ? -26.543 -2.658 -6.583 1.00 25.64 ? 902 NAG A C7 1 HETATM 4800 C C8 . NAG C 2 . ? -25.168 -2.593 -5.981 1.00 25.61 ? 902 NAG A C8 1 HETATM 4801 N N2 . NAG C 2 . ? -27.369 -1.629 -6.370 1.00 24.89 ? 902 NAG A N2 1 HETATM 4802 O O3 . NAG C 2 . ? -28.147 0.354 -8.165 1.00 25.32 ? 902 NAG A O3 1 HETATM 4803 O O4 . NAG C 2 . ? -30.791 1.342 -7.871 1.00 26.40 ? 902 NAG A O4 1 HETATM 4804 O O5 . NAG C 2 . ? -31.053 -2.047 -6.603 1.00 24.69 ? 902 NAG A O5 1 HETATM 4805 O O6 . NAG C 2 . ? -33.737 -0.926 -6.290 1.00 26.99 ? 902 NAG A O6 1 HETATM 4806 O O7 . NAG C 2 . ? -26.861 -3.652 -7.230 1.00 26.73 ? 902 NAG A O7 1 HETATM 4807 C C1 . NAG D 2 . ? -33.052 -0.605 37.885 1.00 19.94 ? 903 NAG A C1 1 HETATM 4808 C C2 . NAG D 2 . ? -33.706 0.485 37.055 1.00 20.77 ? 903 NAG A C2 1 HETATM 4809 C C3 . NAG D 2 . ? -32.760 1.049 36.003 1.00 21.46 ? 903 NAG A C3 1 HETATM 4810 C C4 . NAG D 2 . ? -31.454 1.499 36.652 1.00 21.92 ? 903 NAG A C4 1 HETATM 4811 C C5 . NAG D 2 . ? -30.929 0.492 37.672 1.00 21.76 ? 903 NAG A C5 1 HETATM 4812 C C6 . NAG D 2 . ? -29.896 1.159 38.566 1.00 22.08 ? 903 NAG A C6 1 HETATM 4813 C C7 . NAG D 2 . ? -36.068 0.709 36.549 1.00 20.80 ? 903 NAG A C7 1 HETATM 4814 C C8 . NAG D 2 . ? -37.290 0.165 35.873 1.00 20.71 ? 903 NAG A C8 1 HETATM 4815 N N2 . NAG D 2 . ? -34.934 0.017 36.435 1.00 20.70 ? 903 NAG A N2 1 HETATM 4816 O O3 . NAG D 2 . ? -33.381 2.149 35.369 1.00 21.21 ? 903 NAG A O3 1 HETATM 4817 O O4 . NAG D 2 . ? -30.453 1.660 35.666 1.00 22.64 ? 903 NAG A O4 1 HETATM 4818 O O5 . NAG D 2 . ? -31.929 -0.042 38.519 1.00 20.69 ? 903 NAG A O5 1 HETATM 4819 O O6 . NAG D 2 . ? -28.994 0.152 38.955 1.00 23.84 ? 903 NAG A O6 1 HETATM 4820 O O7 . NAG D 2 . ? -36.145 1.759 37.186 1.00 20.93 ? 903 NAG A O7 1 HETATM 4821 C C1 . NAG E 2 . ? -30.356 3.003 35.165 1.00 23.74 ? 904 NAG A C1 1 HETATM 4822 C C2 . NAG E 2 . ? -28.933 3.192 34.670 1.00 24.50 ? 904 NAG A C2 1 HETATM 4823 C C3 . NAG E 2 . ? -28.753 4.571 34.067 1.00 25.59 ? 904 NAG A C3 1 HETATM 4824 C C4 . NAG E 2 . ? -29.806 4.802 33.005 1.00 26.47 ? 904 NAG A C4 1 HETATM 4825 C C5 . NAG E 2 . ? -31.215 4.480 33.488 1.00 25.69 ? 904 NAG A C5 1 HETATM 4826 C C6 . NAG E 2 . ? -32.146 4.442 32.281 1.00 25.86 ? 904 NAG A C6 1 HETATM 4827 C C7 . NAG E 2 . ? -27.181 1.985 35.865 1.00 24.11 ? 904 NAG A C7 1 HETATM 4828 C C8 . NAG E 2 . ? -26.272 1.937 37.060 1.00 24.01 ? 904 NAG A C8 1 HETATM 4829 N N2 . NAG E 2 . ? -28.000 3.027 35.764 1.00 24.11 ? 904 NAG A N2 1 HETATM 4830 O O3 . NAG E 2 . ? -27.486 4.646 33.462 1.00 25.48 ? 904 NAG A O3 1 HETATM 4831 O O4 . NAG E 2 . ? -29.756 6.158 32.649 1.00 29.12 ? 904 NAG A O4 1 HETATM 4832 O O5 . NAG E 2 . ? -31.271 3.220 34.118 1.00 24.24 ? 904 NAG A O5 1 HETATM 4833 O O6 . NAG E 2 . ? -33.430 4.047 32.692 1.00 27.93 ? 904 NAG A O6 1 HETATM 4834 O O7 . NAG E 2 . ? -27.148 1.079 35.040 1.00 24.23 ? 904 NAG A O7 1 HETATM 4835 C C1 . BMA F 3 . ? -29.589 6.331 31.234 1.00 32.13 ? 905 BMA A C1 1 HETATM 4836 C C2 . BMA F 3 . ? -30.172 7.687 30.844 1.00 33.56 ? 905 BMA A C2 1 HETATM 4837 C C3 . BMA F 3 . ? -30.054 7.886 29.339 1.00 36.04 ? 905 BMA A C3 1 HETATM 4838 C C4 . BMA F 3 . ? -28.603 7.682 28.911 1.00 36.52 ? 905 BMA A C4 1 HETATM 4839 C C5 . BMA F 3 . ? -28.003 6.380 29.451 1.00 36.71 ? 905 BMA A C5 1 HETATM 4840 C C6 . BMA F 3 . ? -26.501 6.335 29.200 1.00 38.86 ? 905 BMA A C6 1 HETATM 4841 O O2 . BMA F 3 . ? -29.491 8.736 31.542 1.00 32.13 ? 905 BMA A O2 1 HETATM 4842 O O3 . BMA F 3 . ? -30.491 9.208 28.978 1.00 39.94 ? 905 BMA A O3 1 HETATM 4843 O O4 . BMA F 3 . ? -28.537 7.649 27.486 1.00 36.79 ? 905 BMA A O4 1 HETATM 4844 O O5 . BMA F 3 . ? -28.218 6.240 30.858 1.00 33.83 ? 905 BMA A O5 1 HETATM 4845 O O6 . BMA F 3 . ? -25.883 7.285 30.069 1.00 42.31 ? 905 BMA A O6 1 HETATM 4846 C C1 . MAN G 4 . ? -24.511 7.539 29.713 1.00 45.73 ? 906 MAN A C1 1 HETATM 4847 C C2 . MAN G 4 . ? -23.893 8.271 30.902 1.00 46.91 ? 906 MAN A C2 1 HETATM 4848 C C3 . MAN G 4 . ? -24.414 9.704 31.008 1.00 47.52 ? 906 MAN A C3 1 HETATM 4849 C C4 . MAN G 4 . ? -24.288 10.434 29.675 1.00 48.38 ? 906 MAN A C4 1 HETATM 4850 C C5 . MAN G 4 . ? -24.884 9.605 28.542 1.00 49.03 ? 906 MAN A C5 1 HETATM 4851 C C6 . MAN G 4 . ? -24.639 10.317 27.212 1.00 50.43 ? 906 MAN A C6 1 HETATM 4852 O O2 . MAN G 4 . ? -22.491 8.266 30.778 1.00 48.01 ? 906 MAN A O2 1 HETATM 4853 O O3 . MAN G 4 . ? -23.714 10.406 32.012 1.00 46.96 ? 906 MAN A O3 1 HETATM 4854 O O4 . MAN G 4 . ? -24.979 11.661 29.740 1.00 48.35 ? 906 MAN A O4 1 HETATM 4855 O O5 . MAN G 4 . ? -24.332 8.296 28.522 1.00 47.52 ? 906 MAN A O5 1 HETATM 4856 O O6 . MAN G 4 . ? -24.801 9.422 26.133 1.00 52.02 ? 906 MAN A O6 1 HETATM 4857 C C1 . MAN H 4 . ? -31.767 9.162 28.300 1.00 43.68 ? 907 MAN A C1 1 HETATM 4858 C C2 . MAN H 4 . ? -32.036 10.534 27.689 1.00 45.39 ? 907 MAN A C2 1 HETATM 4859 C C3 . MAN H 4 . ? -32.382 11.531 28.793 1.00 46.25 ? 907 MAN A C3 1 HETATM 4860 C C4 . MAN H 4 . ? -33.522 11.017 29.662 1.00 45.85 ? 907 MAN A C4 1 HETATM 4861 C C5 . MAN H 4 . ? -33.139 9.650 30.217 1.00 45.54 ? 907 MAN A C5 1 HETATM 4862 C C6 . MAN H 4 . ? -34.250 9.071 31.092 1.00 45.16 ? 907 MAN A C6 1 HETATM 4863 O O2 . MAN H 4 . ? -33.078 10.446 26.727 1.00 47.28 ? 907 MAN A O2 1 HETATM 4864 O O3 . MAN H 4 . ? -32.706 12.787 28.246 1.00 47.84 ? 907 MAN A O3 1 HETATM 4865 O O4 . MAN H 4 . ? -33.741 11.925 30.720 1.00 47.62 ? 907 MAN A O4 1 HETATM 4866 O O5 . MAN H 4 . ? -32.842 8.765 29.147 1.00 44.68 ? 907 MAN A O5 1 HETATM 4867 O O6 . MAN H 4 . ? -33.869 7.799 31.566 1.00 44.64 ? 907 MAN A O6 1 HETATM 4868 C C1 . MAN I 4 . ? -32.636 10.762 25.382 1.00 48.16 ? 908 MAN A C1 1 HETATM 4869 C C2 . MAN I 4 . ? -33.840 11.059 24.482 1.00 48.74 ? 908 MAN A C2 1 HETATM 4870 C C3 . MAN I 4 . ? -34.651 9.789 24.262 1.00 48.91 ? 908 MAN A C3 1 HETATM 4871 C C4 . MAN I 4 . ? -33.742 8.726 23.654 1.00 48.63 ? 908 MAN A C4 1 HETATM 4872 C C5 . MAN I 4 . ? -32.538 8.510 24.569 1.00 47.97 ? 908 MAN A C5 1 HETATM 4873 C C6 . MAN I 4 . ? -31.566 7.499 23.969 1.00 47.64 ? 908 MAN A C6 1 HETATM 4874 O O2 . MAN I 4 . ? -33.401 11.560 23.233 1.00 48.82 ? 908 MAN A O2 1 HETATM 4875 O O3 . MAN I 4 . ? -35.769 10.025 23.437 1.00 48.08 ? 908 MAN A O3 1 HETATM 4876 O O4 . MAN I 4 . ? -34.458 7.522 23.491 1.00 48.98 ? 908 MAN A O4 1 HETATM 4877 O O5 . MAN I 4 . ? -31.857 9.732 24.795 1.00 47.60 ? 908 MAN A O5 1 HETATM 4878 O O6 . MAN I 4 . ? -32.171 6.225 23.940 1.00 45.18 ? 908 MAN A O6 1 HETATM 4879 C C1 . GOL J 5 . ? -22.271 -16.865 -7.444 1.00 31.89 ? 909 GOL A C1 1 HETATM 4880 O O1 . GOL J 5 . ? -21.587 -16.426 -6.266 1.00 32.59 ? 909 GOL A O1 1 HETATM 4881 C C2 . GOL J 5 . ? -23.654 -17.393 -7.075 1.00 31.36 ? 909 GOL A C2 1 HETATM 4882 O O2 . GOL J 5 . ? -23.538 -18.752 -6.649 1.00 29.77 ? 909 GOL A O2 1 HETATM 4883 C C3 . GOL J 5 . ? -24.275 -16.547 -5.965 1.00 30.43 ? 909 GOL A C3 1 HETATM 4884 O O3 . GOL J 5 . ? -25.661 -16.864 -5.799 1.00 29.63 ? 909 GOL A O3 1 HETATM 4885 C C1 . GOL K 5 . ? -17.159 -16.238 33.087 1.00 18.96 ? 910 GOL A C1 1 HETATM 4886 O O1 . GOL K 5 . ? -16.375 -17.428 32.984 1.00 18.93 ? 910 GOL A O1 1 HETATM 4887 C C2 . GOL K 5 . ? -17.166 -15.570 31.720 1.00 18.88 ? 910 GOL A C2 1 HETATM 4888 O O2 . GOL K 5 . ? -17.738 -16.463 30.756 1.00 19.04 ? 910 GOL A O2 1 HETATM 4889 C C3 . GOL K 5 . ? -17.955 -14.271 31.771 1.00 18.56 ? 910 GOL A C3 1 HETATM 4890 O O3 . GOL K 5 . ? -18.007 -13.718 30.457 1.00 18.41 ? 910 GOL A O3 1 HETATM 4891 C C1 . GOL L 5 . ? -14.938 -28.389 32.601 1.00 23.65 ? 911 GOL A C1 1 HETATM 4892 O O1 . GOL L 5 . ? -15.367 -28.308 31.247 1.00 23.52 ? 911 GOL A O1 1 HETATM 4893 C C2 . GOL L 5 . ? -14.049 -27.189 32.878 1.00 23.94 ? 911 GOL A C2 1 HETATM 4894 O O2 . GOL L 5 . ? -14.151 -26.851 34.266 1.00 24.35 ? 911 GOL A O2 1 HETATM 4895 C C3 . GOL L 5 . ? -12.627 -27.531 32.441 1.00 23.85 ? 911 GOL A C3 1 HETATM 4896 O O3 . GOL L 5 . ? -12.563 -27.726 31.014 1.00 23.49 ? 911 GOL A O3 1 HETATM 4897 C C1 . GOL M 5 . ? -46.582 -4.385 35.922 1.00 29.12 ? 912 GOL A C1 1 HETATM 4898 O O1 . GOL M 5 . ? -47.476 -5.404 35.465 1.00 30.08 ? 912 GOL A O1 1 HETATM 4899 C C2 . GOL M 5 . ? -45.140 -4.745 35.583 1.00 28.32 ? 912 GOL A C2 1 HETATM 4900 O O2 . GOL M 5 . ? -44.477 -3.613 35.003 1.00 27.15 ? 912 GOL A O2 1 HETATM 4901 C C3 . GOL M 5 . ? -44.406 -5.179 36.845 1.00 28.10 ? 912 GOL A C3 1 HETATM 4902 O O3 . GOL M 5 . ? -43.071 -5.565 36.510 1.00 27.32 ? 912 GOL A O3 1 HETATM 4903 C C1 . GOL N 5 . ? -34.882 -3.622 -2.596 1.00 24.55 ? 913 GOL A C1 1 HETATM 4904 O O1 . GOL N 5 . ? -35.294 -4.436 -3.698 1.00 25.46 ? 913 GOL A O1 1 HETATM 4905 C C2 . GOL N 5 . ? -35.031 -4.444 -1.323 1.00 24.14 ? 913 GOL A C2 1 HETATM 4906 O O2 . GOL N 5 . ? -33.963 -5.406 -1.277 1.00 23.44 ? 913 GOL A O2 1 HETATM 4907 C C3 . GOL N 5 . ? -35.000 -3.521 -0.102 1.00 23.61 ? 913 GOL A C3 1 HETATM 4908 O O3 . GOL N 5 . ? -35.234 -4.250 1.111 1.00 23.07 ? 913 GOL A O3 1 HETATM 4909 C C1 . GOL O 5 . ? -33.375 -32.759 26.153 1.00 29.89 ? 914 GOL A C1 1 HETATM 4910 O O1 . GOL O 5 . ? -34.293 -31.771 25.670 1.00 29.33 ? 914 GOL A O1 1 HETATM 4911 C C2 . GOL O 5 . ? -32.021 -32.666 25.451 1.00 30.17 ? 914 GOL A C2 1 HETATM 4912 O O2 . GOL O 5 . ? -31.371 -31.421 25.734 1.00 30.44 ? 914 GOL A O2 1 HETATM 4913 C C3 . GOL O 5 . ? -31.131 -33.804 25.939 1.00 30.03 ? 914 GOL A C3 1 HETATM 4914 O O3 . GOL O 5 . ? -31.575 -35.065 25.425 1.00 30.16 ? 914 GOL A O3 1 HETATM 4915 CL CL . CL P 6 . ? -28.451 -0.681 13.261 1.00 14.40 ? 915 CL A CL 1 HETATM 4916 S S . SO4 Q 7 . ? -10.766 -18.821 13.921 1.00 51.65 ? 916 SO4 A S 1 HETATM 4917 O O1 . SO4 Q 7 . ? -9.763 -18.166 13.055 1.00 51.66 ? 916 SO4 A O1 1 HETATM 4918 O O2 . SO4 Q 7 . ? -11.858 -19.380 13.091 1.00 53.05 ? 916 SO4 A O2 1 HETATM 4919 O O3 . SO4 Q 7 . ? -10.129 -19.914 14.689 1.00 52.33 ? 916 SO4 A O3 1 HETATM 4920 O O4 . SO4 Q 7 . ? -11.330 -17.821 14.849 1.00 52.39 ? 916 SO4 A O4 1 HETATM 4921 O O . HOH R 8 . ? -28.307 -5.832 26.565 1.00 9.31 ? 1001 HOH A O 1 HETATM 4922 O O . HOH R 8 . ? -37.954 -7.704 6.744 1.00 9.51 ? 1002 HOH A O 1 HETATM 4923 O O . HOH R 8 . ? -14.990 -28.297 23.609 1.00 11.87 ? 1003 HOH A O 1 HETATM 4924 O O . HOH R 8 . ? -18.581 -32.734 9.621 1.00 19.75 ? 1004 HOH A O 1 HETATM 4925 O O . HOH R 8 . ? -25.239 -7.103 23.498 1.00 11.08 ? 1005 HOH A O 1 HETATM 4926 O O . HOH R 8 . ? -20.556 -8.526 12.262 1.00 19.24 ? 1006 HOH A O 1 HETATM 4927 O O . HOH R 8 . ? -24.162 -7.639 8.444 1.00 11.51 ? 1007 HOH A O 1 HETATM 4928 O O . HOH R 8 . ? -17.585 -3.016 15.658 1.00 11.36 ? 1008 HOH A O 1 HETATM 4929 O O . HOH R 8 . ? -9.837 1.313 22.966 1.00 13.84 ? 1009 HOH A O 1 HETATM 4930 O O . HOH R 8 . ? -25.495 -3.767 13.004 1.00 11.59 ? 1010 HOH A O 1 HETATM 4931 O O . HOH R 8 . ? -24.586 -4.394 1.968 1.00 15.84 ? 1011 HOH A O 1 HETATM 4932 O O . HOH R 8 . ? -32.703 -8.745 16.963 1.00 11.62 ? 1012 HOH A O 1 HETATM 4933 O O . HOH R 8 . ? -21.855 -8.611 15.808 1.00 14.34 ? 1013 HOH A O 1 HETATM 4934 O O . HOH R 8 . ? -35.254 -7.547 7.668 1.00 8.00 ? 1014 HOH A O 1 HETATM 4935 O O . HOH R 8 . ? -24.236 -9.152 14.462 1.00 9.49 ? 1015 HOH A O 1 HETATM 4936 O O . HOH R 8 . ? -10.981 3.097 15.332 1.00 19.24 ? 1016 HOH A O 1 HETATM 4937 O O . HOH R 8 . ? -16.442 -0.337 18.212 1.00 18.81 ? 1017 HOH A O 1 HETATM 4938 O O . HOH R 8 . ? -12.886 -17.768 7.509 1.00 18.70 ? 1018 HOH A O 1 HETATM 4939 O O . HOH R 8 . ? -34.550 -15.764 18.202 1.00 17.96 ? 1019 HOH A O 1 HETATM 4940 O O . HOH R 8 . ? -20.985 -16.011 12.443 1.00 15.59 ? 1020 HOH A O 1 HETATM 4941 O O . HOH R 8 . ? -11.843 -14.094 7.252 1.00 26.34 ? 1021 HOH A O 1 HETATM 4942 O O . HOH R 8 . ? -25.087 -4.918 8.837 1.00 11.85 ? 1022 HOH A O 1 HETATM 4943 O O . HOH R 8 . ? -29.022 -14.050 31.661 1.00 9.41 ? 1023 HOH A O 1 HETATM 4944 O O . HOH R 8 . ? -36.963 -10.696 19.825 1.00 12.94 ? 1024 HOH A O 1 HETATM 4945 O O . HOH R 8 . ? -19.479 -33.639 24.247 1.00 13.75 ? 1025 HOH A O 1 HETATM 4946 O O . HOH R 8 . ? -1.346 -7.894 15.952 1.00 17.25 ? 1026 HOH A O 1 HETATM 4947 O O . HOH R 8 . ? -31.861 -3.790 22.783 1.00 12.06 ? 1027 HOH A O 1 HETATM 4948 O O . HOH R 8 . ? -18.081 4.646 17.250 1.00 22.00 ? 1028 HOH A O 1 HETATM 4949 O O . HOH R 8 . ? -23.563 4.524 16.545 1.00 15.64 ? 1029 HOH A O 1 HETATM 4950 O O . HOH R 8 . ? -19.454 11.997 1.283 1.00 26.83 ? 1030 HOH A O 1 HETATM 4951 O O . HOH R 8 . ? 4.082 13.477 7.163 1.00 16.06 ? 1031 HOH A O 1 HETATM 4952 O O . HOH R 8 . ? 4.107 12.426 12.125 1.00 14.23 ? 1032 HOH A O 1 HETATM 4953 O O . HOH R 8 . ? -2.196 17.245 18.667 1.00 16.08 ? 1033 HOH A O 1 HETATM 4954 O O . HOH R 8 . ? -21.893 -26.721 8.349 1.00 14.57 ? 1034 HOH A O 1 HETATM 4955 O O . HOH R 8 . ? -27.010 -25.658 23.657 1.00 15.36 ? 1035 HOH A O 1 HETATM 4956 O O . HOH R 8 . ? -5.103 -13.803 12.154 1.00 29.52 ? 1036 HOH A O 1 HETATM 4957 O O . HOH R 8 . ? -20.615 -34.059 8.282 1.00 20.44 ? 1037 HOH A O 1 HETATM 4958 O O . HOH R 8 . ? -33.657 -19.832 -9.605 1.00 17.01 ? 1038 HOH A O 1 HETATM 4959 O O . HOH R 8 . ? -37.461 -21.185 29.027 1.00 16.03 ? 1039 HOH A O 1 HETATM 4960 O O . HOH R 8 . ? -18.835 -17.362 26.109 1.00 7.61 ? 1040 HOH A O 1 HETATM 4961 O O . HOH R 8 . ? -27.088 5.380 9.039 1.00 13.11 ? 1041 HOH A O 1 HETATM 4962 O O . HOH R 8 . ? -35.493 -18.191 32.423 1.00 10.37 ? 1042 HOH A O 1 HETATM 4963 O O . HOH R 8 . ? -32.504 -36.409 17.830 1.00 26.02 ? 1043 HOH A O 1 HETATM 4964 O O . HOH R 8 . ? -12.237 -34.282 31.187 1.00 17.79 ? 1044 HOH A O 1 HETATM 4965 O O . HOH R 8 . ? -31.228 -2.406 0.207 1.00 11.71 ? 1045 HOH A O 1 HETATM 4966 O O . HOH R 8 . ? -37.483 -2.663 23.850 1.00 6.26 ? 1046 HOH A O 1 HETATM 4967 O O . HOH R 8 . ? -24.021 -42.260 34.276 1.00 26.27 ? 1047 HOH A O 1 HETATM 4968 O O . HOH R 8 . ? -9.902 -3.066 15.931 1.00 11.82 ? 1048 HOH A O 1 HETATM 4969 O O . HOH R 8 . ? -8.751 -8.222 16.922 1.00 7.22 ? 1049 HOH A O 1 HETATM 4970 O O . HOH R 8 . ? -17.615 -21.095 19.479 1.00 16.83 ? 1050 HOH A O 1 HETATM 4971 O O . HOH R 8 . ? -16.302 -18.717 21.036 1.00 25.82 ? 1051 HOH A O 1 HETATM 4972 O O . HOH R 8 . ? -14.809 -30.569 30.388 1.00 11.95 ? 1052 HOH A O 1 HETATM 4973 O O . HOH R 8 . ? -11.297 -4.156 13.778 1.00 11.28 ? 1053 HOH A O 1 HETATM 4974 O O . HOH R 8 . ? -18.208 -17.107 19.243 1.00 16.16 ? 1054 HOH A O 1 HETATM 4975 O O . HOH R 8 . ? -30.940 -16.508 27.964 1.00 9.47 ? 1055 HOH A O 1 HETATM 4976 O O . HOH R 8 . ? -30.842 -19.330 27.967 1.00 16.24 ? 1056 HOH A O 1 HETATM 4977 O O . HOH R 8 . ? -36.451 -17.608 34.968 1.00 9.76 ? 1057 HOH A O 1 HETATM 4978 O O . HOH R 8 . ? -30.345 -26.218 9.959 1.00 16.56 ? 1058 HOH A O 1 HETATM 4979 O O . HOH R 8 . ? -40.810 -9.217 17.574 1.00 14.13 ? 1059 HOH A O 1 HETATM 4980 O O . HOH R 8 . ? -21.339 -3.702 26.364 1.00 19.16 ? 1060 HOH A O 1 HETATM 4981 O O . HOH R 8 . ? -35.140 -0.129 5.532 1.00 17.86 ? 1061 HOH A O 1 HETATM 4982 O O . HOH R 8 . ? -20.981 -39.148 26.617 1.00 9.59 ? 1062 HOH A O 1 HETATM 4983 O O . HOH R 8 . ? -16.069 -24.351 36.321 1.00 15.35 ? 1063 HOH A O 1 HETATM 4984 O O . HOH R 8 . ? -2.077 20.053 12.378 1.00 16.38 ? 1064 HOH A O 1 HETATM 4985 O O . HOH R 8 . ? -1.880 19.860 19.702 1.00 20.45 ? 1065 HOH A O 1 HETATM 4986 O O . HOH R 8 . ? -41.312 -12.681 10.939 1.00 8.08 ? 1066 HOH A O 1 HETATM 4987 O O . HOH R 8 . ? -31.128 0.924 32.373 1.00 12.75 ? 1067 HOH A O 1 HETATM 4988 O O . HOH R 8 . ? -21.398 -25.950 19.173 1.00 20.90 ? 1068 HOH A O 1 HETATM 4989 O O . HOH R 8 . ? -23.923 -19.424 -2.388 1.00 14.46 ? 1069 HOH A O 1 HETATM 4990 O O . HOH R 8 . ? 6.702 1.894 9.058 1.00 16.03 ? 1070 HOH A O 1 HETATM 4991 O O . HOH R 8 . ? -31.419 -4.629 -1.356 1.00 10.43 ? 1071 HOH A O 1 HETATM 4992 O O . HOH R 8 . ? 7.820 18.818 26.239 1.00 17.28 ? 1072 HOH A O 1 HETATM 4993 O O . HOH R 8 . ? 6.328 1.993 11.787 1.00 9.32 ? 1073 HOH A O 1 HETATM 4994 O O . HOH R 8 . ? -27.579 -11.740 37.650 1.00 7.21 ? 1074 HOH A O 1 HETATM 4995 O O . HOH R 8 . ? -15.671 -39.812 8.634 1.00 14.59 ? 1075 HOH A O 1 HETATM 4996 O O . HOH R 8 . ? -5.748 -8.663 -2.035 1.00 26.08 ? 1076 HOH A O 1 HETATM 4997 O O . HOH R 8 . ? -0.845 -0.824 3.128 1.00 15.50 ? 1077 HOH A O 1 HETATM 4998 O O . HOH R 8 . ? -38.269 -18.384 -11.260 1.00 14.04 ? 1078 HOH A O 1 HETATM 4999 O O . HOH R 8 . ? 8.182 4.189 8.339 1.00 17.08 ? 1079 HOH A O 1 HETATM 5000 O O . HOH R 8 . ? -35.323 -13.650 37.035 1.00 15.11 ? 1080 HOH A O 1 HETATM 5001 O O . HOH R 8 . ? 4.279 -4.432 14.397 1.00 11.57 ? 1081 HOH A O 1 HETATM 5002 O O . HOH R 8 . ? -1.765 -0.167 -7.261 1.00 16.59 ? 1082 HOH A O 1 HETATM 5003 O O . HOH R 8 . ? -5.730 -7.927 7.847 1.00 15.02 ? 1083 HOH A O 1 HETATM 5004 O O . HOH R 8 . ? -37.745 -33.382 -1.771 1.00 17.39 ? 1084 HOH A O 1 HETATM 5005 O O . HOH R 8 . ? 5.951 -0.887 11.205 1.00 20.74 ? 1085 HOH A O 1 HETATM 5006 O O . HOH R 8 . ? -47.675 -6.372 6.537 1.00 25.54 ? 1086 HOH A O 1 HETATM 5007 O O . HOH R 8 . ? -11.351 15.960 14.714 1.00 33.03 ? 1087 HOH A O 1 HETATM 5008 O O . HOH R 8 . ? -40.920 -5.980 14.005 1.00 23.53 ? 1088 HOH A O 1 HETATM 5009 O O . HOH R 8 . ? -34.999 -15.313 34.859 1.00 16.26 ? 1089 HOH A O 1 HETATM 5010 O O . HOH R 8 . ? 15.208 12.770 18.187 1.00 22.41 ? 1090 HOH A O 1 HETATM 5011 O O . HOH R 8 . ? -36.663 -7.289 -3.850 1.00 17.58 ? 1091 HOH A O 1 HETATM 5012 O O . HOH R 8 . ? -28.821 -38.633 24.836 1.00 13.82 ? 1092 HOH A O 1 HETATM 5013 O O . HOH R 8 . ? -29.429 -15.315 -7.638 1.00 12.22 ? 1093 HOH A O 1 HETATM 5014 O O . HOH R 8 . ? -31.219 -13.306 -4.316 1.00 14.58 ? 1094 HOH A O 1 HETATM 5015 O O . HOH R 8 . ? -37.118 2.600 11.139 1.00 13.64 ? 1095 HOH A O 1 HETATM 5016 O O . HOH R 8 . ? -26.551 -12.509 -5.496 1.00 13.10 ? 1096 HOH A O 1 HETATM 5017 O O . HOH R 8 . ? -27.586 -15.124 -5.361 1.00 15.13 ? 1097 HOH A O 1 HETATM 5018 O O . HOH R 8 . ? -22.482 -13.681 -7.444 1.00 16.34 ? 1098 HOH A O 1 HETATM 5019 O O . HOH R 8 . ? -27.467 -14.641 -9.335 1.00 23.38 ? 1099 HOH A O 1 HETATM 5020 O O . HOH R 8 . ? -34.277 -0.260 2.066 1.00 12.66 ? 1100 HOH A O 1 HETATM 5021 O O . HOH R 8 . ? -39.291 -19.851 40.138 1.00 18.13 ? 1101 HOH A O 1 HETATM 5022 O O . HOH R 8 . ? -1.061 -2.904 -2.239 1.00 16.58 ? 1102 HOH A O 1 HETATM 5023 O O . HOH R 8 . ? 7.621 -0.813 8.955 1.00 27.97 ? 1103 HOH A O 1 HETATM 5024 O O . HOH R 8 . ? -40.717 -2.201 20.138 1.00 22.17 ? 1104 HOH A O 1 HETATM 5025 O O . HOH R 8 . ? -37.475 -35.630 -0.349 1.00 15.39 ? 1105 HOH A O 1 HETATM 5026 O O . HOH R 8 . ? -41.370 -30.722 -0.718 1.00 16.74 ? 1106 HOH A O 1 HETATM 5027 O O . HOH R 8 . ? 7.977 -4.717 8.329 1.00 16.96 ? 1107 HOH A O 1 HETATM 5028 O O . HOH R 8 . ? -28.049 -19.392 42.009 1.00 15.14 ? 1108 HOH A O 1 HETATM 5029 O O . HOH R 8 . ? -32.884 -20.623 29.447 1.00 13.55 ? 1109 HOH A O 1 HETATM 5030 O O . HOH R 8 . ? -47.791 -4.652 32.720 1.00 21.51 ? 1110 HOH A O 1 HETATM 5031 O O . HOH R 8 . ? -44.549 -12.081 7.152 1.00 16.73 ? 1111 HOH A O 1 HETATM 5032 O O . HOH R 8 . ? -30.220 -30.571 27.822 1.00 12.35 ? 1112 HOH A O 1 HETATM 5033 O O . HOH R 8 . ? -25.604 -17.520 -3.218 1.00 20.53 ? 1113 HOH A O 1 HETATM 5034 O O . HOH R 8 . ? -28.940 -14.188 -2.928 1.00 16.54 ? 1114 HOH A O 1 HETATM 5035 O O . HOH R 8 . ? 6.313 -3.407 12.332 1.00 18.49 ? 1115 HOH A O 1 HETATM 5036 O O . HOH R 8 . ? -3.476 -6.552 7.618 1.00 15.52 ? 1116 HOH A O 1 HETATM 5037 O O . HOH R 8 . ? -25.702 -44.623 4.623 1.00 22.60 ? 1117 HOH A O 1 HETATM 5038 O O . HOH R 8 . ? -42.240 -15.330 19.364 1.00 20.35 ? 1118 HOH A O 1 HETATM 5039 O O . HOH R 8 . ? -32.072 -29.981 23.600 1.00 17.26 ? 1119 HOH A O 1 HETATM 5040 O O . HOH R 8 . ? -18.173 -23.075 37.675 1.00 10.00 ? 1120 HOH A O 1 HETATM 5041 O O . HOH R 8 . ? -16.021 -20.002 26.655 1.00 10.94 ? 1121 HOH A O 1 HETATM 5042 O O . HOH R 8 . ? -17.988 -40.497 7.360 1.00 15.97 ? 1122 HOH A O 1 HETATM 5043 O O . HOH R 8 . ? -9.247 -15.298 23.059 1.00 21.30 ? 1123 HOH A O 1 HETATM 5044 O O . HOH R 8 . ? -35.958 -17.408 40.756 1.00 17.74 ? 1124 HOH A O 1 HETATM 5045 O O . HOH R 8 . ? -35.146 -32.177 9.046 1.00 18.45 ? 1125 HOH A O 1 HETATM 5046 O O . HOH R 8 . ? -19.708 -37.480 1.083 1.00 14.30 ? 1126 HOH A O 1 HETATM 5047 O O . HOH R 8 . ? -33.977 -30.679 -6.424 1.00 16.34 ? 1127 HOH A O 1 HETATM 5048 O O . HOH R 8 . ? -32.722 -24.665 25.116 1.00 22.92 ? 1128 HOH A O 1 HETATM 5049 O O . HOH R 8 . ? -20.420 -42.949 9.238 1.00 23.72 ? 1129 HOH A O 1 HETATM 5050 O O . HOH R 8 . ? -40.257 -14.384 40.135 1.00 14.31 ? 1130 HOH A O 1 HETATM 5051 O O . HOH R 8 . ? -13.251 -11.437 2.397 1.00 22.69 ? 1131 HOH A O 1 HETATM 5052 O O . HOH R 8 . ? -38.379 0.443 23.003 1.00 20.12 ? 1132 HOH A O 1 HETATM 5053 O O . HOH R 8 . ? -9.271 -0.352 -2.321 1.00 14.96 ? 1133 HOH A O 1 HETATM 5054 O O . HOH R 8 . ? -1.039 13.875 5.489 1.00 21.60 ? 1134 HOH A O 1 HETATM 5055 O O . HOH R 8 . ? -27.196 -3.415 36.473 1.00 18.97 ? 1135 HOH A O 1 HETATM 5056 O O . HOH R 8 . ? -14.354 -12.096 10.850 1.00 20.09 ? 1136 HOH A O 1 HETATM 5057 O O . HOH R 8 . ? -16.132 -22.775 9.858 1.00 21.25 ? 1137 HOH A O 1 HETATM 5058 O O . HOH R 8 . ? -37.306 -26.538 17.704 1.00 15.91 ? 1138 HOH A O 1 HETATM 5059 O O . HOH R 8 . ? -41.343 -27.892 2.523 1.00 21.75 ? 1139 HOH A O 1 HETATM 5060 O O . HOH R 8 . ? -29.443 -17.890 25.398 1.00 20.98 ? 1140 HOH A O 1 HETATM 5061 O O . HOH R 8 . ? -6.222 14.023 28.883 1.00 17.55 ? 1141 HOH A O 1 HETATM 5062 O O . HOH R 8 . ? 2.382 3.255 1.964 1.00 20.73 ? 1142 HOH A O 1 HETATM 5063 O O . HOH R 8 . ? -34.376 -40.806 -4.281 1.00 21.63 ? 1143 HOH A O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 GLU 1 27 ? ? ? A . n A 1 2 ALA 2 28 28 ALA ALA A . n A 1 3 PRO 3 29 29 PRO PRO A . n A 1 4 HIS 4 30 30 HIS HIS A . n A 1 5 LEU 5 31 31 LEU LEU A . n A 1 6 VAL 6 32 32 VAL VAL A . n A 1 7 GLN 7 33 33 GLN GLN A . n A 1 8 VAL 8 34 34 VAL VAL A . n A 1 9 ASP 9 35 35 ASP ASP A . n A 1 10 ALA 10 36 36 ALA ALA A . n A 1 11 ALA 11 37 37 ALA ALA A . n A 1 12 ARG 12 38 38 ARG ARG A . n A 1 13 ALA 13 39 39 ALA ALA A . n A 1 14 LEU 14 40 40 LEU LEU A . n A 1 15 TRP 15 41 41 TRP TRP A . n A 1 16 PRO 16 42 42 PRO PRO A . n A 1 17 LEU 17 43 43 LEU LEU A . n A 1 18 ARG 18 44 44 ARG ARG A . n A 1 19 ARG 19 45 45 ARG ARG A . n A 1 20 PHE 20 46 46 PHE PHE A . n A 1 21 TRP 21 47 47 TRP TRP A . n A 1 22 ARG 22 48 48 ARG ARG A . n A 1 23 SER 23 49 49 SER SER A . n A 1 24 THR 24 50 50 THR THR A . n A 1 25 GLY 25 51 51 GLY GLY A . n A 1 26 PHE 26 52 52 PHE PHE A . n A 1 27 CYS 27 53 53 CYS CYS A . n A 1 28 PRO 28 54 54 PRO PRO A . n A 1 29 PRO 29 55 ? ? ? A . n A 1 30 LEU 30 56 ? ? ? A . n A 1 31 PRO 31 57 ? ? ? A . n A 1 32 HIS 32 58 ? ? ? A . n A 1 33 SER 33 59 ? ? ? A . n A 1 34 GLN 34 60 ? ? ? A . n A 1 35 ALA 35 61 ? ? ? A . n A 1 36 ASP 36 62 ? ? ? A . n A 1 37 PRO 37 63 63 PRO PRO A . n A 1 38 TYR 38 64 64 TYR TYR A . n A 1 39 VAL 39 65 65 VAL VAL A . n A 1 40 LEU 40 66 66 LEU LEU A . n A 1 41 SER 41 67 67 SER SER A . n A 1 42 TRP 42 68 68 TRP TRP A . n A 1 43 ASP 43 69 69 ASP ASP A . n A 1 44 GLN 44 70 70 GLN GLN A . n A 1 45 GLN 45 71 71 GLN GLN A . n A 1 46 LEU 46 72 72 LEU LEU A . n A 1 47 ASN 47 73 73 ASN ASN A . n A 1 48 LEU 48 74 74 LEU LEU A . n A 1 49 ALA 49 75 75 ALA ALA A . n A 1 50 TYR 50 76 76 TYR TYR A . n A 1 51 VAL 51 77 77 VAL VAL A . n A 1 52 GLY 52 78 78 GLY GLY A . n A 1 53 ALA 53 79 79 ALA ALA A . n A 1 54 VAL 54 80 80 VAL VAL A . n A 1 55 PRO 55 81 81 PRO PRO A . n A 1 56 HIS 56 82 82 HIS HIS A . n A 1 57 ARG 57 83 83 ARG ARG A . n A 1 58 GLY 58 84 84 GLY GLY A . n A 1 59 ILE 59 85 85 ILE ILE A . n A 1 60 LYS 60 86 86 LYS LYS A . n A 1 61 GLN 61 87 87 GLN GLN A . n A 1 62 VAL 62 88 88 VAL VAL A . n A 1 63 ARG 63 89 89 ARG ARG A . n A 1 64 THR 64 90 90 THR THR A . n A 1 65 HIS 65 91 91 HIS HIS A . n A 1 66 TRP 66 92 92 TRP TRP A . n A 1 67 LEU 67 93 93 LEU LEU A . n A 1 68 LEU 68 94 94 LEU LEU A . n A 1 69 GLU 69 95 95 GLU GLU A . n A 1 70 LEU 70 96 96 LEU LEU A . n A 1 71 VAL 71 97 97 VAL VAL A . n A 1 72 THR 72 98 98 THR THR A . n A 1 73 THR 73 99 99 THR THR A . n A 1 74 ARG 74 100 ? ? ? A . n A 1 75 GLY 75 101 ? ? ? A . n A 1 76 SER 76 102 ? ? ? A . n A 1 77 THR 77 103 ? ? ? A . n A 1 78 GLY 78 104 ? ? ? A . n A 1 79 GLN 79 105 ? ? ? A . n A 1 80 GLY 80 106 ? ? ? A . n A 1 81 LEU 81 107 107 LEU LEU A . n A 1 82 SER 82 108 108 SER SER A . n A 1 83 TYR 83 109 109 TYR TYR A . n A 1 84 ASN 84 110 110 ASN ASN A . n A 1 85 PHE 85 111 111 PHE PHE A . n A 1 86 THR 86 112 112 THR THR A . n A 1 87 HIS 87 113 113 HIS HIS A . n A 1 88 LEU 88 114 114 LEU LEU A . n A 1 89 ASP 89 115 115 ASP ASP A . n A 1 90 GLY 90 116 116 GLY GLY A . n A 1 91 TYR 91 117 117 TYR TYR A . n A 1 92 LEU 92 118 118 LEU LEU A . n A 1 93 ASP 93 119 119 ASP ASP A . n A 1 94 LEU 94 120 120 LEU LEU A . n A 1 95 LEU 95 121 121 LEU LEU A . n A 1 96 ARG 96 122 122 ARG ARG A . n A 1 97 GLU 97 123 123 GLU GLU A . n A 1 98 ASN 98 124 124 ASN ASN A . n A 1 99 GLN 99 125 125 GLN GLN A . n A 1 100 LEU 100 126 126 LEU LEU A . n A 1 101 LEU 101 127 127 LEU LEU A . n A 1 102 PRO 102 128 128 PRO PRO A . n A 1 103 GLY 103 129 129 GLY GLY A . n A 1 104 PHE 104 130 130 PHE PHE A . n A 1 105 GLU 105 131 131 GLU GLU A . n A 1 106 LEU 106 132 132 LEU LEU A . n A 1 107 MET 107 133 133 MET MET A . n A 1 108 GLY 108 134 134 GLY GLY A . n A 1 109 SER 109 135 135 SER SER A . n A 1 110 ALA 110 136 136 ALA ALA A . n A 1 111 SER 111 137 137 SER SER A . n A 1 112 GLY 112 138 138 GLY GLY A . n A 1 113 HIS 113 139 139 HIS HIS A . n A 1 114 PHE 114 140 140 PHE PHE A . n A 1 115 THR 115 141 141 THR THR A . n A 1 116 ASP 116 142 142 ASP ASP A . n A 1 117 PHE 117 143 143 PHE PHE A . n A 1 118 GLU 118 144 144 GLU GLU A . n A 1 119 ASP 119 145 145 ASP ASP A . n A 1 120 LYS 120 146 146 LYS LYS A . n A 1 121 GLN 121 147 147 GLN GLN A . n A 1 122 GLN 122 148 148 GLN GLN A . n A 1 123 VAL 123 149 149 VAL VAL A . n A 1 124 PHE 124 150 150 PHE PHE A . n A 1 125 GLU 125 151 151 GLU GLU A . n A 1 126 TRP 126 152 152 TRP TRP A . n A 1 127 LYS 127 153 153 LYS LYS A . n A 1 128 ASP 128 154 154 ASP ASP A . n A 1 129 LEU 129 155 155 LEU LEU A . n A 1 130 VAL 130 156 156 VAL VAL A . n A 1 131 SER 131 157 157 SER SER A . n A 1 132 SER 132 158 158 SER SER A . n A 1 133 LEU 133 159 159 LEU LEU A . n A 1 134 ALA 134 160 160 ALA ALA A . n A 1 135 ARG 135 161 161 ARG ARG A . n A 1 136 ARG 136 162 162 ARG ARG A . n A 1 137 TYR 137 163 163 TYR TYR A . n A 1 138 ILE 138 164 164 ILE ILE A . n A 1 139 GLY 139 165 165 GLY GLY A . n A 1 140 ARG 140 166 166 ARG ARG A . n A 1 141 TYR 141 167 167 TYR TYR A . n A 1 142 GLY 142 168 168 GLY GLY A . n A 1 143 LEU 143 169 169 LEU LEU A . n A 1 144 ALA 144 170 170 ALA ALA A . n A 1 145 HIS 145 171 171 HIS HIS A . n A 1 146 VAL 146 172 172 VAL VAL A . n A 1 147 SER 147 173 173 SER SER A . n A 1 148 LYS 148 174 174 LYS LYS A . n A 1 149 TRP 149 175 175 TRP TRP A . n A 1 150 ASN 150 176 176 ASN ASN A . n A 1 151 PHE 151 177 177 PHE PHE A . n A 1 152 GLU 152 178 178 GLU GLU A . n A 1 153 THR 153 179 179 THR THR A . n A 1 154 TRP 154 180 180 TRP TRP A . n A 1 155 ASN 155 181 181 ASN ASN A . n A 1 156 GLU 156 182 182 GLU GLU A . n A 1 157 PRO 157 183 183 PRO PRO A . n A 1 158 ASP 158 184 184 ASP ASP A . n A 1 159 HIS 159 185 185 HIS HIS A . n A 1 160 HIS 160 186 186 HIS HIS A . n A 1 161 ASP 161 187 187 ASP ASP A . n A 1 162 PHE 162 188 188 PHE PHE A . n A 1 163 ASP 163 189 189 ASP ASP A . n A 1 164 ASN 164 190 190 ASN ASN A . n A 1 165 VAL 165 191 191 VAL VAL A . n A 1 166 SER 166 192 192 SER SER A . n A 1 167 MET 167 193 193 MET MET A . n A 1 168 THR 168 194 194 THR THR A . n A 1 169 MET 169 195 195 MET MET A . n A 1 170 GLN 170 196 196 GLN GLN A . n A 1 171 GLY 171 197 197 GLY GLY A . n A 1 172 PHE 172 198 198 PHE PHE A . n A 1 173 LEU 173 199 199 LEU LEU A . n A 1 174 ASN 174 200 200 ASN ASN A . n A 1 175 TYR 175 201 201 TYR TYR A . n A 1 176 TYR 176 202 202 TYR TYR A . n A 1 177 ASP 177 203 203 ASP ASP A . n A 1 178 ALA 178 204 204 ALA ALA A . n A 1 179 CYS 179 205 205 CYS CYS A . n A 1 180 SER 180 206 206 SER SER A . n A 1 181 GLU 181 207 207 GLU GLU A . n A 1 182 GLY 182 208 208 GLY GLY A . n A 1 183 LEU 183 209 209 LEU LEU A . n A 1 184 ARG 184 210 210 ARG ARG A . n A 1 185 ALA 185 211 211 ALA ALA A . n A 1 186 ALA 186 212 212 ALA ALA A . n A 1 187 SER 187 213 213 SER SER A . n A 1 188 PRO 188 214 214 PRO PRO A . n A 1 189 ALA 189 215 215 ALA ALA A . n A 1 190 LEU 190 216 216 LEU LEU A . n A 1 191 ARG 191 217 217 ARG ARG A . n A 1 192 LEU 192 218 218 LEU LEU A . n A 1 193 GLY 193 219 219 GLY GLY A . n A 1 194 GLY 194 220 220 GLY GLY A . n A 1 195 PRO 195 221 221 PRO PRO A . n A 1 196 GLY 196 222 222 GLY GLY A . n A 1 197 ASP 197 223 223 ASP ASP A . n A 1 198 SER 198 224 224 SER SER A . n A 1 199 PHE 199 225 225 PHE PHE A . n A 1 200 HIS 200 226 226 HIS HIS A . n A 1 201 THR 201 227 227 THR THR A . n A 1 202 PRO 202 228 228 PRO PRO A . n A 1 203 PRO 203 229 229 PRO PRO A . n A 1 204 ARG 204 230 230 ARG ARG A . n A 1 205 SER 205 231 231 SER SER A . n A 1 206 PRO 206 232 232 PRO PRO A . n A 1 207 LEU 207 233 233 LEU LEU A . n A 1 208 SER 208 234 234 SER SER A . n A 1 209 TRP 209 235 235 TRP TRP A . n A 1 210 GLY 210 236 236 GLY GLY A . n A 1 211 LEU 211 237 237 LEU LEU A . n A 1 212 LEU 212 238 238 LEU LEU A . n A 1 213 ARG 213 239 239 ARG ARG A . n A 1 214 HIS 214 240 240 HIS HIS A . n A 1 215 CYS 215 241 241 CYS CYS A . n A 1 216 HIS 216 242 242 HIS HIS A . n A 1 217 ASP 217 243 243 ASP ASP A . n A 1 218 GLY 218 244 244 GLY GLY A . n A 1 219 THR 219 245 245 THR THR A . n A 1 220 ASN 220 246 246 ASN ASN A . n A 1 221 PHE 221 247 247 PHE PHE A . n A 1 222 PHE 222 248 248 PHE PHE A . n A 1 223 THR 223 249 249 THR THR A . n A 1 224 GLY 224 250 250 GLY GLY A . n A 1 225 GLU 225 251 251 GLU GLU A . n A 1 226 ALA 226 252 252 ALA ALA A . n A 1 227 GLY 227 253 253 GLY GLY A . n A 1 228 VAL 228 254 254 VAL VAL A . n A 1 229 ARG 229 255 255 ARG ARG A . n A 1 230 LEU 230 256 256 LEU LEU A . n A 1 231 ASP 231 257 257 ASP ASP A . n A 1 232 TYR 232 258 258 TYR TYR A . n A 1 233 ILE 233 259 259 ILE ILE A . n A 1 234 SER 234 260 260 SER SER A . n A 1 235 LEU 235 261 261 LEU LEU A . n A 1 236 HIS 236 262 262 HIS HIS A . n A 1 237 ARG 237 263 263 ARG ARG A . n A 1 238 LYS 238 264 264 LYS LYS A . n A 1 239 GLY 239 265 265 GLY GLY A . n A 1 240 ALA 240 266 266 ALA ALA A . n A 1 241 ARG 241 267 267 ARG ARG A . n A 1 242 SER 242 268 268 SER SER A . n A 1 243 SER 243 269 269 SER SER A . n A 1 244 ILE 244 270 270 ILE ILE A . n A 1 245 SER 245 271 271 SER SER A . n A 1 246 ILE 246 272 272 ILE ILE A . n A 1 247 LEU 247 273 273 LEU LEU A . n A 1 248 GLU 248 274 274 GLU GLU A . n A 1 249 GLN 249 275 275 GLN GLN A . n A 1 250 GLU 250 276 276 GLU GLU A . n A 1 251 LYS 251 277 277 LYS LYS A . n A 1 252 VAL 252 278 278 VAL VAL A . n A 1 253 VAL 253 279 279 VAL VAL A . n A 1 254 ALA 254 280 280 ALA ALA A . n A 1 255 GLN 255 281 281 GLN GLN A . n A 1 256 GLN 256 282 282 GLN GLN A . n A 1 257 ILE 257 283 283 ILE ILE A . n A 1 258 ARG 258 284 284 ARG ARG A . n A 1 259 GLN 259 285 285 GLN GLN A . n A 1 260 LEU 260 286 286 LEU LEU A . n A 1 261 PHE 261 287 287 PHE PHE A . n A 1 262 PRO 262 288 288 PRO PRO A . n A 1 263 LYS 263 289 289 LYS LYS A . n A 1 264 PHE 264 290 290 PHE PHE A . n A 1 265 ALA 265 291 291 ALA ALA A . n A 1 266 ASP 266 292 292 ASP ASP A . n A 1 267 THR 267 293 293 THR THR A . n A 1 268 PRO 268 294 294 PRO PRO A . n A 1 269 ILE 269 295 295 ILE ILE A . n A 1 270 TYR 270 296 296 TYR TYR A . n A 1 271 ASN 271 297 297 ASN ASN A . n A 1 272 ASP 272 298 298 ASP ASP A . n A 1 273 GLU 273 299 299 GLU GLU A . n A 1 274 ALA 274 300 300 ALA ALA A . n A 1 275 ASP 275 301 301 ASP ASP A . n A 1 276 PRO 276 302 302 PRO PRO A . n A 1 277 LEU 277 303 303 LEU LEU A . n A 1 278 VAL 278 304 304 VAL VAL A . n A 1 279 GLY 279 305 305 GLY GLY A . n A 1 280 TRP 280 306 306 TRP TRP A . n A 1 281 SER 281 307 307 SER SER A . n A 1 282 LEU 282 308 308 LEU LEU A . n A 1 283 PRO 283 309 309 PRO PRO A . n A 1 284 GLN 284 310 310 GLN GLN A . n A 1 285 PRO 285 311 311 PRO PRO A . n A 1 286 TRP 286 312 312 TRP TRP A . n A 1 287 ARG 287 313 313 ARG ARG A . n A 1 288 ALA 288 314 314 ALA ALA A . n A 1 289 ASP 289 315 315 ASP ASP A . n A 1 290 VAL 290 316 316 VAL VAL A . n A 1 291 THR 291 317 317 THR THR A . n A 1 292 TYR 292 318 318 TYR TYR A . n A 1 293 ALA 293 319 319 ALA ALA A . n A 1 294 ALA 294 320 320 ALA ALA A . n A 1 295 MET 295 321 321 MET MET A . n A 1 296 VAL 296 322 322 VAL VAL A . n A 1 297 VAL 297 323 323 VAL VAL A . n A 1 298 LYS 298 324 324 LYS LYS A . n A 1 299 VAL 299 325 325 VAL VAL A . n A 1 300 ILE 300 326 326 ILE ILE A . n A 1 301 ALA 301 327 327 ALA ALA A . n A 1 302 GLN 302 328 328 GLN GLN A . n A 1 303 HIS 303 329 329 HIS HIS A . n A 1 304 GLN 304 330 330 GLN GLN A . n A 1 305 ASN 305 331 331 ASN ASN A . n A 1 306 LEU 306 332 332 LEU LEU A . n A 1 307 LEU 307 333 333 LEU LEU A . n A 1 308 LEU 308 334 334 LEU LEU A . n A 1 309 ALA 309 335 335 ALA ALA A . n A 1 310 ASN 310 336 ? ? ? A . n A 1 311 THR 311 337 ? ? ? A . n A 1 312 THR 312 338 ? ? ? A . n A 1 313 SER 313 339 ? ? ? A . n A 1 314 ALA 314 340 340 ALA ALA A . n A 1 315 PHE 315 341 341 PHE PHE A . n A 1 316 PRO 316 342 342 PRO PRO A . n A 1 317 TYR 317 343 343 TYR TYR A . n A 1 318 ALA 318 344 344 ALA ALA A . n A 1 319 LEU 319 345 345 LEU LEU A . n A 1 320 LEU 320 346 346 LEU LEU A . n A 1 321 SER 321 347 347 SER SER A . n A 1 322 ASN 322 348 348 ASN ASN A . n A 1 323 ASP 323 349 349 ASP ASP A . n A 1 324 ASN 324 350 350 ASN ASN A . n A 1 325 ALA 325 351 351 ALA ALA A . n A 1 326 PHE 326 352 352 PHE PHE A . n A 1 327 LEU 327 353 353 LEU LEU A . n A 1 328 SER 328 354 354 SER SER A . n A 1 329 TYR 329 355 355 TYR TYR A . n A 1 330 HIS 330 356 356 HIS HIS A . n A 1 331 PRO 331 357 357 PRO PRO A . n A 1 332 HIS 332 358 358 HIS HIS A . n A 1 333 PRO 333 359 359 PRO PRO A . n A 1 334 PHE 334 360 360 PHE PHE A . n A 1 335 ALA 335 361 361 ALA ALA A . n A 1 336 GLN 336 362 362 GLN GLN A . n A 1 337 ARG 337 363 363 ARG ARG A . n A 1 338 THR 338 364 364 THR THR A . n A 1 339 LEU 339 365 365 LEU LEU A . n A 1 340 THR 340 366 366 THR THR A . n A 1 341 ALA 341 367 367 ALA ALA A . n A 1 342 ARG 342 368 368 ARG ARG A . n A 1 343 PHE 343 369 369 PHE PHE A . n A 1 344 GLN 344 370 370 GLN GLN A . n A 1 345 VAL 345 371 371 VAL VAL A . n A 1 346 ASN 346 372 372 ASN ASN A . n A 1 347 ASN 347 373 373 ASN ASN A . n A 1 348 THR 348 374 374 THR THR A . n A 1 349 ARG 349 375 375 ARG ARG A . n A 1 350 PRO 350 376 376 PRO PRO A . n A 1 351 PRO 351 377 377 PRO PRO A . n A 1 352 HIS 352 378 378 HIS HIS A . n A 1 353 VAL 353 379 379 VAL VAL A . n A 1 354 GLN 354 380 380 GLN GLN A . n A 1 355 LEU 355 381 381 LEU LEU A . n A 1 356 LEU 356 382 382 LEU LEU A . n A 1 357 ARG 357 383 383 ARG ARG A . n A 1 358 LYS 358 384 384 LYS LYS A . n A 1 359 PRO 359 385 385 PRO PRO A . n A 1 360 VAL 360 386 386 VAL VAL A . n A 1 361 LEU 361 387 387 LEU LEU A . n A 1 362 THR 362 388 388 THR THR A . n A 1 363 ALA 363 389 389 ALA ALA A . n A 1 364 MET 364 390 390 MET MET A . n A 1 365 GLY 365 391 391 GLY GLY A . n A 1 366 LEU 366 392 392 LEU LEU A . n A 1 367 LEU 367 393 393 LEU LEU A . n A 1 368 ALA 368 394 394 ALA ALA A . n A 1 369 LEU 369 395 395 LEU LEU A . n A 1 370 LEU 370 396 396 LEU LEU A . n A 1 371 ASP 371 397 397 ASP ASP A . n A 1 372 GLU 372 398 398 GLU GLU A . n A 1 373 GLU 373 399 399 GLU GLU A . n A 1 374 GLN 374 400 400 GLN GLN A . n A 1 375 LEU 375 401 401 LEU LEU A . n A 1 376 TRP 376 402 402 TRP TRP A . n A 1 377 ALA 377 403 403 ALA ALA A . n A 1 378 GLU 378 404 404 GLU GLU A . n A 1 379 VAL 379 405 405 VAL VAL A . n A 1 380 SER 380 406 406 SER SER A . n A 1 381 GLN 381 407 407 GLN GLN A . n A 1 382 ALA 382 408 408 ALA ALA A . n A 1 383 GLY 383 409 409 GLY GLY A . n A 1 384 THR 384 410 410 THR THR A . n A 1 385 VAL 385 411 411 VAL VAL A . n A 1 386 LEU 386 412 412 LEU LEU A . n A 1 387 ASP 387 413 413 ASP ASP A . n A 1 388 SER 388 414 414 SER SER A . n A 1 389 ASN 389 415 415 ASN ASN A . n A 1 390 HIS 390 416 416 HIS HIS A . n A 1 391 THR 391 417 417 THR THR A . n A 1 392 VAL 392 418 418 VAL VAL A . n A 1 393 GLY 393 419 419 GLY GLY A . n A 1 394 VAL 394 420 420 VAL VAL A . n A 1 395 LEU 395 421 421 LEU LEU A . n A 1 396 ALA 396 422 422 ALA ALA A . n A 1 397 SER 397 423 423 SER SER A . n A 1 398 ALA 398 424 424 ALA ALA A . n A 1 399 HIS 399 425 425 HIS HIS A . n A 1 400 ARG 400 426 426 ARG ARG A . n A 1 401 PRO 401 427 427 PRO PRO A . n A 1 402 GLN 402 428 428 GLN GLN A . n A 1 403 GLY 403 429 429 GLY GLY A . n A 1 404 PRO 404 430 430 PRO PRO A . n A 1 405 ALA 405 431 431 ALA ALA A . n A 1 406 ASP 406 432 432 ASP ASP A . n A 1 407 ALA 407 433 433 ALA ALA A . n A 1 408 TRP 408 434 434 TRP TRP A . n A 1 409 ARG 409 435 435 ARG ARG A . n A 1 410 ALA 410 436 436 ALA ALA A . n A 1 411 ALA 411 437 437 ALA ALA A . n A 1 412 VAL 412 438 438 VAL VAL A . n A 1 413 LEU 413 439 439 LEU LEU A . n A 1 414 ILE 414 440 440 ILE ILE A . n A 1 415 TYR 415 441 441 TYR TYR A . n A 1 416 ALA 416 442 442 ALA ALA A . n A 1 417 SER 417 443 443 SER SER A . n A 1 418 ASP 418 444 444 ASP ASP A . n A 1 419 ASP 419 445 445 ASP ASP A . n A 1 420 THR 420 446 446 THR THR A . n A 1 421 ARG 421 447 447 ARG ARG A . n A 1 422 ALA 422 448 448 ALA ALA A . n A 1 423 HIS 423 449 449 HIS HIS A . n A 1 424 PRO 424 450 450 PRO PRO A . n A 1 425 ASN 425 451 451 ASN ASN A . n A 1 426 ARG 426 452 452 ARG ARG A . n A 1 427 SER 427 453 453 SER SER A . n A 1 428 VAL 428 454 454 VAL VAL A . n A 1 429 ALA 429 455 455 ALA ALA A . n A 1 430 VAL 430 456 456 VAL VAL A . n A 1 431 THR 431 457 457 THR THR A . n A 1 432 LEU 432 458 458 LEU LEU A . n A 1 433 ARG 433 459 459 ARG ARG A . n A 1 434 LEU 434 460 460 LEU LEU A . n A 1 435 ARG 435 461 461 ARG ARG A . n A 1 436 GLY 436 462 462 GLY GLY A . n A 1 437 VAL 437 463 463 VAL VAL A . n A 1 438 PRO 438 464 464 PRO PRO A . n A 1 439 PRO 439 465 465 PRO PRO A . n A 1 440 GLY 440 466 466 GLY GLY A . n A 1 441 PRO 441 467 467 PRO PRO A . n A 1 442 GLY 442 468 468 GLY GLY A . n A 1 443 LEU 443 469 469 LEU LEU A . n A 1 444 VAL 444 470 470 VAL VAL A . n A 1 445 TYR 445 471 471 TYR TYR A . n A 1 446 VAL 446 472 472 VAL VAL A . n A 1 447 THR 447 473 473 THR THR A . n A 1 448 ARG 448 474 474 ARG ARG A . n A 1 449 TYR 449 475 475 TYR TYR A . n A 1 450 LEU 450 476 476 LEU LEU A . n A 1 451 ASP 451 477 477 ASP ASP A . n A 1 452 ASN 452 478 478 ASN ASN A . n A 1 453 GLY 453 479 479 GLY GLY A . n A 1 454 LEU 454 480 480 LEU LEU A . n A 1 455 CYS 455 481 481 CYS CYS A . n A 1 456 SER 456 482 482 SER SER A . n A 1 457 PRO 457 483 483 PRO PRO A . n A 1 458 ASP 458 484 484 ASP ASP A . n A 1 459 GLY 459 485 485 GLY GLY A . n A 1 460 GLU 460 486 486 GLU GLU A . n A 1 461 TRP 461 487 487 TRP TRP A . n A 1 462 ARG 462 488 488 ARG ARG A . n A 1 463 ARG 463 489 489 ARG ARG A . n A 1 464 LEU 464 490 490 LEU LEU A . n A 1 465 GLY 465 491 491 GLY GLY A . n A 1 466 ARG 466 492 492 ARG ARG A . n A 1 467 PRO 467 493 493 PRO PRO A . n A 1 468 VAL 468 494 494 VAL VAL A . n A 1 469 PHE 469 495 495 PHE PHE A . n A 1 470 PRO 470 496 496 PRO PRO A . n A 1 471 THR 471 497 497 THR THR A . n A 1 472 ALA 472 498 498 ALA ALA A . n A 1 473 GLU 473 499 499 GLU GLU A . n A 1 474 GLN 474 500 500 GLN GLN A . n A 1 475 PHE 475 501 501 PHE PHE A . n A 1 476 ARG 476 502 502 ARG ARG A . n A 1 477 ARG 477 503 503 ARG ARG A . n A 1 478 MET 478 504 504 MET MET A . n A 1 479 ARG 479 505 505 ARG ARG A . n A 1 480 ALA 480 506 506 ALA ALA A . n A 1 481 ALA 481 507 507 ALA ALA A . n A 1 482 GLU 482 508 508 GLU GLU A . n A 1 483 ASP 483 509 509 ASP ASP A . n A 1 484 PRO 484 510 510 PRO PRO A . n A 1 485 VAL 485 511 511 VAL VAL A . n A 1 486 ALA 486 512 512 ALA ALA A . n A 1 487 ALA 487 513 513 ALA ALA A . n A 1 488 ALA 488 514 514 ALA ALA A . n A 1 489 PRO 489 515 515 PRO PRO A . n A 1 490 ARG 490 516 516 ARG ARG A . n A 1 491 PRO 491 517 517 PRO PRO A . n A 1 492 LEU 492 518 518 LEU LEU A . n A 1 493 PRO 493 519 519 PRO PRO A . n A 1 494 ALA 494 520 520 ALA ALA A . n A 1 495 GLY 495 521 521 GLY GLY A . n A 1 496 GLY 496 522 522 GLY GLY A . n A 1 497 ARG 497 523 523 ARG ARG A . n A 1 498 LEU 498 524 524 LEU LEU A . n A 1 499 THR 499 525 525 THR THR A . n A 1 500 LEU 500 526 526 LEU LEU A . n A 1 501 ARG 501 527 527 ARG ARG A . n A 1 502 PRO 502 528 528 PRO PRO A . n A 1 503 ALA 503 529 529 ALA ALA A . n A 1 504 LEU 504 530 530 LEU LEU A . n A 1 505 ARG 505 531 531 ARG ARG A . n A 1 506 LEU 506 532 532 LEU LEU A . n A 1 507 PRO 507 533 533 PRO PRO A . n A 1 508 SER 508 534 534 SER SER A . n A 1 509 LEU 509 535 535 LEU LEU A . n A 1 510 LEU 510 536 536 LEU LEU A . n A 1 511 LEU 511 537 537 LEU LEU A . n A 1 512 VAL 512 538 538 VAL VAL A . n A 1 513 HIS 513 539 539 HIS HIS A . n A 1 514 VAL 514 540 540 VAL VAL A . n A 1 515 CYS 515 541 541 CYS CYS A . n A 1 516 ALA 516 542 542 ALA ALA A . n A 1 517 ARG 517 543 543 ARG ARG A . n A 1 518 PRO 518 544 544 PRO PRO A . n A 1 519 GLU 519 545 545 GLU GLU A . n A 1 520 LYS 520 546 546 LYS LYS A . n A 1 521 PRO 521 547 547 PRO PRO A . n A 1 522 PRO 522 548 548 PRO PRO A . n A 1 523 GLY 523 549 549 GLY GLY A . n A 1 524 GLN 524 550 550 GLN GLN A . n A 1 525 VAL 525 551 551 VAL VAL A . n A 1 526 THR 526 552 552 THR THR A . n A 1 527 ARG 527 553 553 ARG ARG A . n A 1 528 LEU 528 554 554 LEU LEU A . n A 1 529 ARG 529 555 555 ARG ARG A . n A 1 530 ALA 530 556 556 ALA ALA A . n A 1 531 LEU 531 557 557 LEU LEU A . n A 1 532 PRO 532 558 558 PRO PRO A . n A 1 533 LEU 533 559 559 LEU LEU A . n A 1 534 THR 534 560 560 THR THR A . n A 1 535 GLN 535 561 561 GLN GLN A . n A 1 536 GLY 536 562 562 GLY GLY A . n A 1 537 GLN 537 563 563 GLN GLN A . n A 1 538 LEU 538 564 564 LEU LEU A . n A 1 539 VAL 539 565 565 VAL VAL A . n A 1 540 LEU 540 566 566 LEU LEU A . n A 1 541 VAL 541 567 567 VAL VAL A . n A 1 542 TRP 542 568 568 TRP TRP A . n A 1 543 SER 543 569 569 SER SER A . n A 1 544 ASP 544 570 570 ASP ASP A . n A 1 545 GLU 545 571 571 GLU GLU A . n A 1 546 HIS 546 572 572 HIS HIS A . n A 1 547 VAL 547 573 573 VAL VAL A . n A 1 548 GLY 548 574 574 GLY GLY A . n A 1 549 SER 549 575 575 SER SER A . n A 1 550 LYS 550 576 576 LYS LYS A . n A 1 551 CYS 551 577 577 CYS CYS A . n A 1 552 LEU 552 578 578 LEU LEU A . n A 1 553 TRP 553 579 579 TRP TRP A . n A 1 554 THR 554 580 580 THR THR A . n A 1 555 TYR 555 581 581 TYR TYR A . n A 1 556 GLU 556 582 582 GLU GLU A . n A 1 557 ILE 557 583 583 ILE ILE A . n A 1 558 GLN 558 584 584 GLN GLN A . n A 1 559 PHE 559 585 585 PHE PHE A . n A 1 560 SER 560 586 586 SER SER A . n A 1 561 GLN 561 587 587 GLN GLN A . n A 1 562 ASP 562 588 588 ASP ASP A . n A 1 563 GLY 563 589 589 GLY GLY A . n A 1 564 LYS 564 590 590 LYS LYS A . n A 1 565 ALA 565 591 591 ALA ALA A . n A 1 566 TYR 566 592 592 TYR TYR A . n A 1 567 THR 567 593 593 THR THR A . n A 1 568 PRO 568 594 594 PRO PRO A . n A 1 569 VAL 569 595 595 VAL VAL A . n A 1 570 SER 570 596 596 SER SER A . n A 1 571 ARG 571 597 597 ARG ARG A . n A 1 572 LYS 572 598 598 LYS LYS A . n A 1 573 PRO 573 599 599 PRO PRO A . n A 1 574 SER 574 600 600 SER SER A . n A 1 575 THR 575 601 601 THR THR A . n A 1 576 PHE 576 602 602 PHE PHE A . n A 1 577 ASN 577 603 603 ASN ASN A . n A 1 578 LEU 578 604 604 LEU LEU A . n A 1 579 PHE 579 605 605 PHE PHE A . n A 1 580 VAL 580 606 606 VAL VAL A . n A 1 581 PHE 581 607 607 PHE PHE A . n A 1 582 SER 582 608 608 SER SER A . n A 1 583 PRO 583 609 609 PRO PRO A . n A 1 584 ASP 584 610 610 ASP ASP A . n A 1 585 THR 585 611 611 THR THR A . n A 1 586 GLY 586 612 612 GLY GLY A . n A 1 587 ALA 587 613 613 ALA ALA A . n A 1 588 VAL 588 614 614 VAL VAL A . n A 1 589 SER 589 615 615 SER SER A . n A 1 590 GLY 590 616 616 GLY GLY A . n A 1 591 SER 591 617 617 SER SER A . n A 1 592 TYR 592 618 618 TYR TYR A . n A 1 593 ARG 593 619 619 ARG ARG A . n A 1 594 VAL 594 620 620 VAL VAL A . n A 1 595 ARG 595 621 621 ARG ARG A . n A 1 596 ALA 596 622 622 ALA ALA A . n A 1 597 LEU 597 623 623 LEU LEU A . n A 1 598 ASP 598 624 624 ASP ASP A . n A 1 599 TYR 599 625 625 TYR TYR A . n A 1 600 TRP 600 626 626 TRP TRP A . n A 1 601 ALA 601 627 627 ALA ALA A . n A 1 602 ARG 602 628 628 ARG ARG A . n A 1 603 PRO 603 629 629 PRO PRO A . n A 1 604 GLY 604 630 630 GLY GLY A . n A 1 605 PRO 605 631 631 PRO PRO A . n A 1 606 PHE 606 632 632 PHE PHE A . n A 1 607 SER 607 633 633 SER SER A . n A 1 608 ASP 608 634 634 ASP ASP A . n A 1 609 PRO 609 635 635 PRO PRO A . n A 1 610 VAL 610 636 636 VAL VAL A . n A 1 611 PRO 611 637 637 PRO PRO A . n A 1 612 TYR 612 638 638 TYR TYR A . n A 1 613 LEU 613 639 639 LEU LEU A . n A 1 614 GLU 614 640 640 GLU GLU A . n A 1 615 VAL 615 641 ? ? ? A . n A 1 616 PRO 616 642 ? ? ? A . n A 1 617 VAL 617 643 ? ? ? A . n A 1 618 PRO 618 644 ? ? ? A . n A 1 619 ARG 619 645 ? ? ? A . n A 1 620 GLY 620 646 ? ? ? A . n A 1 621 PRO 621 647 ? ? ? A . n A 1 622 PRO 622 648 ? ? ? A . n A 1 623 SER 623 649 ? ? ? A . n A 1 624 PRO 624 650 ? ? ? A . n A 1 625 GLY 625 651 ? ? ? A . n A 1 626 ASN 626 652 ? ? ? A . n A 1 627 PRO 627 653 ? ? ? A . n # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 346 A ASN 372 ? ASN 'GLYCOSYLATION SITE' 2 A ASN 389 A ASN 415 ? ASN 'GLYCOSYLATION SITE' 3 A ASN 84 A ASN 110 ? ASN 'GLYCOSYLATION SITE' # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details software_defined_assembly _pdbx_struct_assembly.method_details PISA _pdbx_struct_assembly.oligomeric_details monomeric _pdbx_struct_assembly.oligomeric_count 1 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # _pdbx_audit_revision_history.ordinal 1 _pdbx_audit_revision_history.data_content_type 'Structure model' _pdbx_audit_revision_history.major_revision 1 _pdbx_audit_revision_history.minor_revision 0 _pdbx_audit_revision_history.revision_date 2015-01-14 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal MxDC 'data collection' . ? 1 PHASER phasing . ? 2 REFMAC refinement 5.7.0029 ? 3 XDS 'data reduction' . ? 4 XDS 'data scaling' . ? 5 # _pdbx_entry_details.entry_id 4OBS _pdbx_entry_details.nonpolymer_details ? _pdbx_entry_details.sequence_details 'H33Q, Q63P, AND R105Q ARE NATURAL VARIANTS.' _pdbx_entry_details.compound_details ? _pdbx_entry_details.source_details ? # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 ASP A 187 ? ? -111.21 73.19 2 1 ASP A 189 ? ? 22.00 -96.73 3 1 ALA A 300 ? ? -96.78 55.04 4 1 ASP A 315 ? ? -147.62 -149.68 5 1 LEU A 333 ? ? -136.76 -55.27 6 1 ASN A 415 ? ? -76.28 46.88 7 1 GLN A 428 ? ? -115.33 -79.13 8 1 ASP A 444 ? ? -104.52 49.78 9 1 ASP A 445 ? ? 55.40 -118.86 10 1 ASN A 451 ? ? -94.31 37.89 11 1 ASP A 588 ? ? -64.47 84.95 12 1 LYS A 590 ? ? -146.69 51.71 13 1 ASN A 603 ? ? -80.00 41.92 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A GLU 27 ? A GLU 1 2 1 Y 1 A PRO 55 ? A PRO 29 3 1 Y 1 A LEU 56 ? A LEU 30 4 1 Y 1 A PRO 57 ? A PRO 31 5 1 Y 1 A HIS 58 ? A HIS 32 6 1 Y 1 A SER 59 ? A SER 33 7 1 Y 1 A GLN 60 ? A GLN 34 8 1 Y 1 A ALA 61 ? A ALA 35 9 1 Y 1 A ASP 62 ? A ASP 36 10 1 Y 1 A ARG 100 ? A ARG 74 11 1 Y 1 A GLY 101 ? A GLY 75 12 1 Y 1 A SER 102 ? A SER 76 13 1 Y 1 A THR 103 ? A THR 77 14 1 Y 1 A GLY 104 ? A GLY 78 15 1 Y 1 A GLN 105 ? A GLN 79 16 1 Y 1 A GLY 106 ? A GLY 80 17 1 Y 1 A ASN 336 ? A ASN 310 18 1 Y 1 A THR 337 ? A THR 311 19 1 Y 1 A THR 338 ? A THR 312 20 1 Y 1 A SER 339 ? A SER 313 21 1 Y 1 A VAL 641 ? A VAL 615 22 1 Y 1 A PRO 642 ? A PRO 616 23 1 Y 1 A VAL 643 ? A VAL 617 24 1 Y 1 A PRO 644 ? A PRO 618 25 1 Y 1 A ARG 645 ? A ARG 619 26 1 Y 1 A GLY 646 ? A GLY 620 27 1 Y 1 A PRO 647 ? A PRO 621 28 1 Y 1 A PRO 648 ? A PRO 622 29 1 Y 1 A SER 649 ? A SER 623 30 1 Y 1 A PRO 650 ? A PRO 624 31 1 Y 1 A GLY 651 ? A GLY 625 32 1 Y 1 A ASN 652 ? A ASN 626 33 1 Y 1 A PRO 653 ? A PRO 627 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 BETA-D-MANNOSE BMA 4 ALPHA-D-MANNOSE MAN 5 GLYCEROL GOL 6 'CHLORIDE ION' CL 7 'SULFATE ION' SO4 8 water HOH # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code B 2 NAG 1 901 901 NAG NAG A . C 2 NAG 1 902 951 NAG NAG A . D 2 NAG 1 903 991 NAG NAG A . E 2 NAG 2 904 992 NAG NAG A . F 3 BMA 3 905 993 BMA BMA A . G 4 MAN 4 906 994 MAN MAN A . H 4 MAN 5 907 995 MAN MAN A . I 4 MAN 6 908 996 MAN MAN A . J 5 GOL 1 909 1 GOL GOL A . K 5 GOL 1 910 2 GOL GOL A . L 5 GOL 1 911 3 GOL GOL A . M 5 GOL 1 912 4 GOL GOL A . N 5 GOL 1 913 5 GOL GOL A . O 5 GOL 1 914 6 GOL GOL A . P 6 CL 1 915 1 CL CL A . Q 7 SO4 1 916 1 SO4 SO4 A . R 8 HOH 1 1001 2 HOH HOH A . R 8 HOH 2 1002 3 HOH HOH A . R 8 HOH 3 1003 4 HOH HOH A . R 8 HOH 4 1004 5 HOH HOH A . R 8 HOH 5 1005 6 HOH HOH A . R 8 HOH 6 1006 7 HOH HOH A . R 8 HOH 7 1007 8 HOH HOH A . R 8 HOH 8 1008 9 HOH HOH A . R 8 HOH 9 1009 10 HOH HOH A . R 8 HOH 10 1010 11 HOH HOH A . R 8 HOH 11 1011 12 HOH HOH A . R 8 HOH 12 1012 13 HOH HOH A . R 8 HOH 13 1013 14 HOH HOH A . R 8 HOH 14 1014 15 HOH HOH A . R 8 HOH 15 1015 16 HOH HOH A . R 8 HOH 16 1016 17 HOH HOH A . R 8 HOH 17 1017 18 HOH HOH A . R 8 HOH 18 1018 19 HOH HOH A . R 8 HOH 19 1019 20 HOH HOH A . R 8 HOH 20 1020 21 HOH HOH A . R 8 HOH 21 1021 22 HOH HOH A . R 8 HOH 22 1022 23 HOH HOH A . R 8 HOH 23 1023 24 HOH HOH A . R 8 HOH 24 1024 25 HOH HOH A . R 8 HOH 25 1025 26 HOH HOH A . R 8 HOH 26 1026 27 HOH HOH A . R 8 HOH 27 1027 28 HOH HOH A . R 8 HOH 28 1028 29 HOH HOH A . R 8 HOH 29 1029 30 HOH HOH A . R 8 HOH 30 1030 31 HOH HOH A . R 8 HOH 31 1031 32 HOH HOH A . R 8 HOH 32 1032 33 HOH HOH A . R 8 HOH 33 1033 34 HOH HOH A . R 8 HOH 34 1034 35 HOH HOH A . R 8 HOH 35 1035 36 HOH HOH A . R 8 HOH 36 1036 38 HOH HOH A . R 8 HOH 37 1037 39 HOH HOH A . R 8 HOH 38 1038 40 HOH HOH A . R 8 HOH 39 1039 41 HOH HOH A . R 8 HOH 40 1040 42 HOH HOH A . R 8 HOH 41 1041 43 HOH HOH A . R 8 HOH 42 1042 44 HOH HOH A . R 8 HOH 43 1043 45 HOH HOH A . R 8 HOH 44 1044 46 HOH HOH A . R 8 HOH 45 1045 49 HOH HOH A . R 8 HOH 46 1046 50 HOH HOH A . R 8 HOH 47 1047 51 HOH HOH A . R 8 HOH 48 1048 52 HOH HOH A . R 8 HOH 49 1049 53 HOH HOH A . R 8 HOH 50 1050 54 HOH HOH A . R 8 HOH 51 1051 55 HOH HOH A . R 8 HOH 52 1052 56 HOH HOH A . R 8 HOH 53 1053 57 HOH HOH A . R 8 HOH 54 1054 58 HOH HOH A . R 8 HOH 55 1055 59 HOH HOH A . R 8 HOH 56 1056 60 HOH HOH A . R 8 HOH 57 1057 61 HOH HOH A . R 8 HOH 58 1058 62 HOH HOH A . R 8 HOH 59 1059 63 HOH HOH A . R 8 HOH 60 1060 64 HOH HOH A . R 8 HOH 61 1061 65 HOH HOH A . R 8 HOH 62 1062 66 HOH HOH A . R 8 HOH 63 1063 69 HOH HOH A . R 8 HOH 64 1064 70 HOH HOH A . R 8 HOH 65 1065 71 HOH HOH A . R 8 HOH 66 1066 72 HOH HOH A . R 8 HOH 67 1067 73 HOH HOH A . R 8 HOH 68 1068 74 HOH HOH A . R 8 HOH 69 1069 75 HOH HOH A . R 8 HOH 70 1070 76 HOH HOH A . R 8 HOH 71 1071 77 HOH HOH A . R 8 HOH 72 1072 78 HOH HOH A . R 8 HOH 73 1073 80 HOH HOH A . R 8 HOH 74 1074 81 HOH HOH A . R 8 HOH 75 1075 82 HOH HOH A . R 8 HOH 76 1076 83 HOH HOH A . R 8 HOH 77 1077 84 HOH HOH A . R 8 HOH 78 1078 86 HOH HOH A . R 8 HOH 79 1079 87 HOH HOH A . R 8 HOH 80 1080 88 HOH HOH A . R 8 HOH 81 1081 89 HOH HOH A . R 8 HOH 82 1082 90 HOH HOH A . R 8 HOH 83 1083 91 HOH HOH A . R 8 HOH 84 1084 92 HOH HOH A . R 8 HOH 85 1085 93 HOH HOH A . R 8 HOH 86 1086 94 HOH HOH A . R 8 HOH 87 1087 95 HOH HOH A . R 8 HOH 88 1088 96 HOH HOH A . R 8 HOH 89 1089 97 HOH HOH A . R 8 HOH 90 1090 98 HOH HOH A . R 8 HOH 91 1091 99 HOH HOH A . R 8 HOH 92 1092 100 HOH HOH A . R 8 HOH 93 1093 101 HOH HOH A . R 8 HOH 94 1094 102 HOH HOH A . R 8 HOH 95 1095 103 HOH HOH A . R 8 HOH 96 1096 104 HOH HOH A . R 8 HOH 97 1097 105 HOH HOH A . R 8 HOH 98 1098 106 HOH HOH A . R 8 HOH 99 1099 107 HOH HOH A . R 8 HOH 100 1100 108 HOH HOH A . R 8 HOH 101 1101 109 HOH HOH A . R 8 HOH 102 1102 111 HOH HOH A . R 8 HOH 103 1103 112 HOH HOH A . R 8 HOH 104 1104 113 HOH HOH A . R 8 HOH 105 1105 114 HOH HOH A . R 8 HOH 106 1106 115 HOH HOH A . R 8 HOH 107 1107 116 HOH HOH A . R 8 HOH 108 1108 118 HOH HOH A . R 8 HOH 109 1109 119 HOH HOH A . R 8 HOH 110 1110 124 HOH HOH A . R 8 HOH 111 1111 129 HOH HOH A . R 8 HOH 112 1112 130 HOH HOH A . R 8 HOH 113 1113 131 HOH HOH A . R 8 HOH 114 1114 132 HOH HOH A . R 8 HOH 115 1115 133 HOH HOH A . R 8 HOH 116 1116 134 HOH HOH A . R 8 HOH 117 1117 135 HOH HOH A . R 8 HOH 118 1118 136 HOH HOH A . R 8 HOH 119 1119 137 HOH HOH A . R 8 HOH 120 1120 138 HOH HOH A . R 8 HOH 121 1121 139 HOH HOH A . R 8 HOH 122 1122 140 HOH HOH A . R 8 HOH 123 1123 141 HOH HOH A . R 8 HOH 124 1124 142 HOH HOH A . R 8 HOH 125 1125 143 HOH HOH A . R 8 HOH 126 1126 144 HOH HOH A . R 8 HOH 127 1127 145 HOH HOH A . R 8 HOH 128 1128 146 HOH HOH A . R 8 HOH 129 1129 147 HOH HOH A . R 8 HOH 130 1130 148 HOH HOH A . R 8 HOH 131 1131 149 HOH HOH A . R 8 HOH 132 1132 150 HOH HOH A . R 8 HOH 133 1133 151 HOH HOH A . R 8 HOH 134 1134 152 HOH HOH A . R 8 HOH 135 1135 153 HOH HOH A . R 8 HOH 136 1136 154 HOH HOH A . R 8 HOH 137 1137 155 HOH HOH A . R 8 HOH 138 1138 156 HOH HOH A . R 8 HOH 139 1139 157 HOH HOH A . R 8 HOH 140 1140 158 HOH HOH A . R 8 HOH 141 1141 159 HOH HOH A . R 8 HOH 142 1142 160 HOH HOH A . R 8 HOH 143 1143 161 HOH HOH A . #