data_4GSX # _entry.id 4GSX # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.287 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 4GSX RCSB RCSB074592 WWPDB D_1000074592 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.details _pdbx_database_related.content_type PDB 3G7T . unspecified PDB 1OK8 . unspecified PDB 1URZ . unspecified PDB 4GT0 . unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 4GSX _pdbx_database_status.recvd_initial_deposition_date 2012-08-28 _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry ? _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? _pdbx_database_status.pdb_format_compatible Y # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Klein, D.E.' 1 'Choi, J.L.' 2 'Harrison, S.C.' 3 # _citation.id primary _citation.title 'Structure of a dengue virus envelope protein late-stage fusion intermediate.' _citation.journal_abbrev J.Virol. _citation.journal_volume 87 _citation.page_first 2287 _citation.page_last 2293 _citation.year 2013 _citation.journal_id_ASTM JOVIAM _citation.country US _citation.journal_id_ISSN 0022-538X _citation.journal_id_CSD 0825 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 23236058 _citation.pdbx_database_id_DOI 10.1128/JVI.02957-12 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Klein, D.E.' 1 primary 'Choi, J.L.' 2 primary 'Harrison, S.C.' 3 # _cell.entry_id 4GSX _cell.length_a 77.571 _cell.length_b 77.571 _cell.length_c 292.518 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 120.00 _cell.Z_PDB 12 _cell.pdbx_unique_axis ? _cell.length_a_esd ? _cell.length_b_esd ? _cell.length_c_esd ? _cell.angle_alpha_esd ? _cell.angle_beta_esd ? _cell.angle_gamma_esd ? # _symmetry.entry_id 4GSX _symmetry.space_group_name_H-M 'P 63' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 173 _symmetry.space_group_name_Hall ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'Envelope protein E' 46796.188 2 ? W101H 'UNP residues 281-691' ? 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 2 ? ? ? ? 3 non-polymer syn 'CADMIUM ION' 112.411 4 ? ? ? ? 4 non-polymer syn 'CHLORIDE ION' 35.453 1 ? ? ? ? 5 water nat water 18.015 666 ? ? ? ? # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;GHHHHHHHHGSSTSNGMRCVGIGNRDFVEGLSGATWVDVVLEHGSCVTTMAKDKPTLDIELLKTEVTNPAVLRKLCIEAK ISNTTTDSRCPTQGEATLVEEQDTNFVCRRTFVDRGHGNGCGLFGKGSLITCAKFKCVTKLEGKIVQYENLKYSVIVTVH TGDQHQVGNETTEHGTIATITPQAPTSEIQLTDYGALTLDCSPRTGLDFNEMVLLTMEKKSWLVHKQWFLDLPLPWTSGA STSQETWNRQDLLVTFKTAHAKKQEVVVLGSQEGAMHTALTGATEIQTSGTTTIFAGHLKCRLKMDKLTLKGMSYVMCTG SFKLEKEVAETQHGTVLVQVKYEGTDAPCKIPFSSQDEKGVTQNGRLITANPIVTDKEKPVNIEAEPPFGESYIVVGAGE KALKLSWFKKGSSIGKMFEATARGARR ; _entity_poly.pdbx_seq_one_letter_code_can ;GHHHHHHHHGSSTSNGMRCVGIGNRDFVEGLSGATWVDVVLEHGSCVTTMAKDKPTLDIELLKTEVTNPAVLRKLCIEAK ISNTTTDSRCPTQGEATLVEEQDTNFVCRRTFVDRGHGNGCGLFGKGSLITCAKFKCVTKLEGKIVQYENLKYSVIVTVH TGDQHQVGNETTEHGTIATITPQAPTSEIQLTDYGALTLDCSPRTGLDFNEMVLLTMEKKSWLVHKQWFLDLPLPWTSGA STSQETWNRQDLLVTFKTAHAKKQEVVVLGSQEGAMHTALTGATEIQTSGTTTIFAGHLKCRLKMDKLTLKGMSYVMCTG SFKLEKEVAETQHGTVLVQVKYEGTDAPCKIPFSSQDEKGVTQNGRLITANPIVTDKEKPVNIEAEPPFGESYIVVGAGE KALKLSWFKKGSSIGKMFEATARGARR ; _entity_poly.pdbx_strand_id A,B _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 GLY n 1 2 HIS n 1 3 HIS n 1 4 HIS n 1 5 HIS n 1 6 HIS n 1 7 HIS n 1 8 HIS n 1 9 HIS n 1 10 GLY n 1 11 SER n 1 12 SER n 1 13 THR n 1 14 SER n 1 15 ASN n 1 16 GLY n 1 17 MET n 1 18 ARG n 1 19 CYS n 1 20 VAL n 1 21 GLY n 1 22 ILE n 1 23 GLY n 1 24 ASN n 1 25 ARG n 1 26 ASP n 1 27 PHE n 1 28 VAL n 1 29 GLU n 1 30 GLY n 1 31 LEU n 1 32 SER n 1 33 GLY n 1 34 ALA n 1 35 THR n 1 36 TRP n 1 37 VAL n 1 38 ASP n 1 39 VAL n 1 40 VAL n 1 41 LEU n 1 42 GLU n 1 43 HIS n 1 44 GLY n 1 45 SER n 1 46 CYS n 1 47 VAL n 1 48 THR n 1 49 THR n 1 50 MET n 1 51 ALA n 1 52 LYS n 1 53 ASP n 1 54 LYS n 1 55 PRO n 1 56 THR n 1 57 LEU n 1 58 ASP n 1 59 ILE n 1 60 GLU n 1 61 LEU n 1 62 LEU n 1 63 LYS n 1 64 THR n 1 65 GLU n 1 66 VAL n 1 67 THR n 1 68 ASN n 1 69 PRO n 1 70 ALA n 1 71 VAL n 1 72 LEU n 1 73 ARG n 1 74 LYS n 1 75 LEU n 1 76 CYS n 1 77 ILE n 1 78 GLU n 1 79 ALA n 1 80 LYS n 1 81 ILE n 1 82 SER n 1 83 ASN n 1 84 THR n 1 85 THR n 1 86 THR n 1 87 ASP n 1 88 SER n 1 89 ARG n 1 90 CYS n 1 91 PRO n 1 92 THR n 1 93 GLN n 1 94 GLY n 1 95 GLU n 1 96 ALA n 1 97 THR n 1 98 LEU n 1 99 VAL n 1 100 GLU n 1 101 GLU n 1 102 GLN n 1 103 ASP n 1 104 THR n 1 105 ASN n 1 106 PHE n 1 107 VAL n 1 108 CYS n 1 109 ARG n 1 110 ARG n 1 111 THR n 1 112 PHE n 1 113 VAL n 1 114 ASP n 1 115 ARG n 1 116 GLY n 1 117 HIS n 1 118 GLY n 1 119 ASN n 1 120 GLY n 1 121 CYS n 1 122 GLY n 1 123 LEU n 1 124 PHE n 1 125 GLY n 1 126 LYS n 1 127 GLY n 1 128 SER n 1 129 LEU n 1 130 ILE n 1 131 THR n 1 132 CYS n 1 133 ALA n 1 134 LYS n 1 135 PHE n 1 136 LYS n 1 137 CYS n 1 138 VAL n 1 139 THR n 1 140 LYS n 1 141 LEU n 1 142 GLU n 1 143 GLY n 1 144 LYS n 1 145 ILE n 1 146 VAL n 1 147 GLN n 1 148 TYR n 1 149 GLU n 1 150 ASN n 1 151 LEU n 1 152 LYS n 1 153 TYR n 1 154 SER n 1 155 VAL n 1 156 ILE n 1 157 VAL n 1 158 THR n 1 159 VAL n 1 160 HIS n 1 161 THR n 1 162 GLY n 1 163 ASP n 1 164 GLN n 1 165 HIS n 1 166 GLN n 1 167 VAL n 1 168 GLY n 1 169 ASN n 1 170 GLU n 1 171 THR n 1 172 THR n 1 173 GLU n 1 174 HIS n 1 175 GLY n 1 176 THR n 1 177 ILE n 1 178 ALA n 1 179 THR n 1 180 ILE n 1 181 THR n 1 182 PRO n 1 183 GLN n 1 184 ALA n 1 185 PRO n 1 186 THR n 1 187 SER n 1 188 GLU n 1 189 ILE n 1 190 GLN n 1 191 LEU n 1 192 THR n 1 193 ASP n 1 194 TYR n 1 195 GLY n 1 196 ALA n 1 197 LEU n 1 198 THR n 1 199 LEU n 1 200 ASP n 1 201 CYS n 1 202 SER n 1 203 PRO n 1 204 ARG n 1 205 THR n 1 206 GLY n 1 207 LEU n 1 208 ASP n 1 209 PHE n 1 210 ASN n 1 211 GLU n 1 212 MET n 1 213 VAL n 1 214 LEU n 1 215 LEU n 1 216 THR n 1 217 MET n 1 218 GLU n 1 219 LYS n 1 220 LYS n 1 221 SER n 1 222 TRP n 1 223 LEU n 1 224 VAL n 1 225 HIS n 1 226 LYS n 1 227 GLN n 1 228 TRP n 1 229 PHE n 1 230 LEU n 1 231 ASP n 1 232 LEU n 1 233 PRO n 1 234 LEU n 1 235 PRO n 1 236 TRP n 1 237 THR n 1 238 SER n 1 239 GLY n 1 240 ALA n 1 241 SER n 1 242 THR n 1 243 SER n 1 244 GLN n 1 245 GLU n 1 246 THR n 1 247 TRP n 1 248 ASN n 1 249 ARG n 1 250 GLN n 1 251 ASP n 1 252 LEU n 1 253 LEU n 1 254 VAL n 1 255 THR n 1 256 PHE n 1 257 LYS n 1 258 THR n 1 259 ALA n 1 260 HIS n 1 261 ALA n 1 262 LYS n 1 263 LYS n 1 264 GLN n 1 265 GLU n 1 266 VAL n 1 267 VAL n 1 268 VAL n 1 269 LEU n 1 270 GLY n 1 271 SER n 1 272 GLN n 1 273 GLU n 1 274 GLY n 1 275 ALA n 1 276 MET n 1 277 HIS n 1 278 THR n 1 279 ALA n 1 280 LEU n 1 281 THR n 1 282 GLY n 1 283 ALA n 1 284 THR n 1 285 GLU n 1 286 ILE n 1 287 GLN n 1 288 THR n 1 289 SER n 1 290 GLY n 1 291 THR n 1 292 THR n 1 293 THR n 1 294 ILE n 1 295 PHE n 1 296 ALA n 1 297 GLY n 1 298 HIS n 1 299 LEU n 1 300 LYS n 1 301 CYS n 1 302 ARG n 1 303 LEU n 1 304 LYS n 1 305 MET n 1 306 ASP n 1 307 LYS n 1 308 LEU n 1 309 THR n 1 310 LEU n 1 311 LYS n 1 312 GLY n 1 313 MET n 1 314 SER n 1 315 TYR n 1 316 VAL n 1 317 MET n 1 318 CYS n 1 319 THR n 1 320 GLY n 1 321 SER n 1 322 PHE n 1 323 LYS n 1 324 LEU n 1 325 GLU n 1 326 LYS n 1 327 GLU n 1 328 VAL n 1 329 ALA n 1 330 GLU n 1 331 THR n 1 332 GLN n 1 333 HIS n 1 334 GLY n 1 335 THR n 1 336 VAL n 1 337 LEU n 1 338 VAL n 1 339 GLN n 1 340 VAL n 1 341 LYS n 1 342 TYR n 1 343 GLU n 1 344 GLY n 1 345 THR n 1 346 ASP n 1 347 ALA n 1 348 PRO n 1 349 CYS n 1 350 LYS n 1 351 ILE n 1 352 PRO n 1 353 PHE n 1 354 SER n 1 355 SER n 1 356 GLN n 1 357 ASP n 1 358 GLU n 1 359 LYS n 1 360 GLY n 1 361 VAL n 1 362 THR n 1 363 GLN n 1 364 ASN n 1 365 GLY n 1 366 ARG n 1 367 LEU n 1 368 ILE n 1 369 THR n 1 370 ALA n 1 371 ASN n 1 372 PRO n 1 373 ILE n 1 374 VAL n 1 375 THR n 1 376 ASP n 1 377 LYS n 1 378 GLU n 1 379 LYS n 1 380 PRO n 1 381 VAL n 1 382 ASN n 1 383 ILE n 1 384 GLU n 1 385 ALA n 1 386 GLU n 1 387 PRO n 1 388 PRO n 1 389 PHE n 1 390 GLY n 1 391 GLU n 1 392 SER n 1 393 TYR n 1 394 ILE n 1 395 VAL n 1 396 VAL n 1 397 GLY n 1 398 ALA n 1 399 GLY n 1 400 GLU n 1 401 LYS n 1 402 ALA n 1 403 LEU n 1 404 LYS n 1 405 LEU n 1 406 SER n 1 407 TRP n 1 408 PHE n 1 409 LYS n 1 410 LYS n 1 411 GLY n 1 412 SER n 1 413 SER n 1 414 ILE n 1 415 GLY n 1 416 LYS n 1 417 MET n 1 418 PHE n 1 419 GLU n 1 420 ALA n 1 421 THR n 1 422 ALA n 1 423 ARG n 1 424 GLY n 1 425 ALA n 1 426 ARG n 1 427 ARG n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name DENV-1 _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene 'Envelope Protein' _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain WP74 _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Dengue virus 1' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 11059 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name 'Cabbage looper' _entity_src_gen.pdbx_host_org_scientific_name 'Trichoplusia ni' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 7111 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain Hi5 _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type Baculovirus _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name pFastBac _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code POLG_DEN1W _struct_ref.pdbx_db_accession P17763 _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;MRCVGIGNRDFVEGLSGATWVDVVLEHGSCVTTMAKDKPTLDIELLKTEVTNPAVLRKLCIEAKISNTTTDSRCPTQGEA TLVEEQDTNFVCRRTFVDRGWGNGCGLFGKGSLITCAKFKCVTKLEGKIVQYENLKYSVIVTVHTGDQHQVGNETTEHGT TATITPQAPTSEIQLTDYGALTLDCSPRTGLDFNEMVLLTMEKKSWLVHKQWFLDLPLPWTSGASTSQETWNRQDLLVTF KTAHAKKQEVVVLGSQEGAMHTALTGATEIQTSGTTTIFAGHLKCRLKMDKLTLKGMSYVMCTGSFKLEKEVAETQHGTV LVQVKYEGTDAPCKIPFSSQDEKGVTQNGRLITANPIVTDKEKPVNIEAEPPFGESYIVVGAGEKALKLSWFKKGSSIGK MFEATARGARR ; _struct_ref.pdbx_align_begin 281 _struct_ref.pdbx_db_isoform ? # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 4GSX A 17 ? 427 ? P17763 281 ? 691 ? 1 411 2 1 4GSX B 17 ? 427 ? P17763 281 ? 691 ? 1 411 # loop_ _struct_ref_seq_dif.align_id _struct_ref_seq_dif.pdbx_pdb_id_code _struct_ref_seq_dif.mon_id _struct_ref_seq_dif.pdbx_pdb_strand_id _struct_ref_seq_dif.seq_num _struct_ref_seq_dif.pdbx_pdb_ins_code _struct_ref_seq_dif.pdbx_seq_db_name _struct_ref_seq_dif.pdbx_seq_db_accession_code _struct_ref_seq_dif.db_mon_id _struct_ref_seq_dif.pdbx_seq_db_seq_num _struct_ref_seq_dif.details _struct_ref_seq_dif.pdbx_auth_seq_num _struct_ref_seq_dif.pdbx_ordinal 1 4GSX GLY A 1 ? UNP P17763 ? ? 'EXPRESSION TAG' -15 1 1 4GSX HIS A 2 ? UNP P17763 ? ? 'EXPRESSION TAG' -14 2 1 4GSX HIS A 3 ? UNP P17763 ? ? 'EXPRESSION TAG' -13 3 1 4GSX HIS A 4 ? UNP P17763 ? ? 'EXPRESSION TAG' -12 4 1 4GSX HIS A 5 ? UNP P17763 ? ? 'EXPRESSION TAG' -11 5 1 4GSX HIS A 6 ? UNP P17763 ? ? 'EXPRESSION TAG' -10 6 1 4GSX HIS A 7 ? UNP P17763 ? ? 'EXPRESSION TAG' -9 7 1 4GSX HIS A 8 ? UNP P17763 ? ? 'EXPRESSION TAG' -8 8 1 4GSX HIS A 9 ? UNP P17763 ? ? 'EXPRESSION TAG' -7 9 1 4GSX GLY A 10 ? UNP P17763 ? ? 'EXPRESSION TAG' -6 10 1 4GSX SER A 11 ? UNP P17763 ? ? 'EXPRESSION TAG' -5 11 1 4GSX SER A 12 ? UNP P17763 ? ? 'EXPRESSION TAG' -4 12 1 4GSX THR A 13 ? UNP P17763 ? ? 'EXPRESSION TAG' -3 13 1 4GSX SER A 14 ? UNP P17763 ? ? 'EXPRESSION TAG' -2 14 1 4GSX ASN A 15 ? UNP P17763 ? ? 'EXPRESSION TAG' -1 15 1 4GSX GLY A 16 ? UNP P17763 ? ? 'EXPRESSION TAG' 0 16 1 4GSX HIS A 117 ? UNP P17763 TRP 381 'ENGINEERED MUTATION' 101 17 1 4GSX ILE A 177 ? UNP P17763 THR 441 CONFLICT 161 18 2 4GSX GLY B 1 ? UNP P17763 ? ? 'EXPRESSION TAG' -15 19 2 4GSX HIS B 2 ? UNP P17763 ? ? 'EXPRESSION TAG' -14 20 2 4GSX HIS B 3 ? UNP P17763 ? ? 'EXPRESSION TAG' -13 21 2 4GSX HIS B 4 ? UNP P17763 ? ? 'EXPRESSION TAG' -12 22 2 4GSX HIS B 5 ? UNP P17763 ? ? 'EXPRESSION TAG' -11 23 2 4GSX HIS B 6 ? UNP P17763 ? ? 'EXPRESSION TAG' -10 24 2 4GSX HIS B 7 ? UNP P17763 ? ? 'EXPRESSION TAG' -9 25 2 4GSX HIS B 8 ? UNP P17763 ? ? 'EXPRESSION TAG' -8 26 2 4GSX HIS B 9 ? UNP P17763 ? ? 'EXPRESSION TAG' -7 27 2 4GSX GLY B 10 ? UNP P17763 ? ? 'EXPRESSION TAG' -6 28 2 4GSX SER B 11 ? UNP P17763 ? ? 'EXPRESSION TAG' -5 29 2 4GSX SER B 12 ? UNP P17763 ? ? 'EXPRESSION TAG' -4 30 2 4GSX THR B 13 ? UNP P17763 ? ? 'EXPRESSION TAG' -3 31 2 4GSX SER B 14 ? UNP P17763 ? ? 'EXPRESSION TAG' -2 32 2 4GSX ASN B 15 ? UNP P17763 ? ? 'EXPRESSION TAG' -1 33 2 4GSX GLY B 16 ? UNP P17763 ? ? 'EXPRESSION TAG' 0 34 2 4GSX HIS B 117 ? UNP P17763 TRP 381 'ENGINEERED MUTATION' 101 35 2 4GSX ILE B 177 ? UNP P17763 THR 441 CONFLICT 161 36 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CD non-polymer . 'CADMIUM ION' ? 'Cd 2' 112.411 CL non-polymer . 'CHLORIDE ION' ? 'Cl -1' 35.453 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 4GSX _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 2.71 _exptl_crystal.density_percent_sol 54.69 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.temp 293 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 4.5 _exptl_crystal_grow.pdbx_details 'pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K' _exptl_crystal_grow.pdbx_pH_range ? # _diffrn.id 1 _diffrn.ambient_temp 200 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type 'ADSC QUANTUM 315' _diffrn_detector.pdbx_collection_date 2011-06-11 _diffrn_detector.details mirrors # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator 'Cryogenically-cooled single crystal' _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength .979 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'APS BEAMLINE 24-ID-E' _diffrn_source.pdbx_synchrotron_site APS _diffrn_source.pdbx_synchrotron_beamline 24-ID-E _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list .979 # _reflns.entry_id 4GSX _reflns.observed_criterion_sigma_I -3 _reflns.observed_criterion_sigma_F -3 _reflns.d_resolution_low 50 _reflns.d_resolution_high 1.90 _reflns.number_obs 76924 _reflns.number_all 76924 _reflns.percent_possible_obs 99.1 _reflns.pdbx_Rmerge_I_obs .104 _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI 14.2 _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy 5.4 _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # _reflns_shell.d_res_high 1.90 _reflns_shell.d_res_low 1.97 _reflns_shell.percent_possible_all 99.3 _reflns_shell.Rmerge_I_obs 0.445 _reflns_shell.pdbx_Rsym_value ? _reflns_shell.meanI_over_sigI_obs 1.84 _reflns_shell.pdbx_redundancy 5.1 _reflns_shell.percent_possible_obs ? _reflns_shell.number_unique_all 7595 _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_unique_obs ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 # _refine.entry_id 4GSX _refine.ls_number_reflns_obs 76852 _refine.ls_number_reflns_all 80731 _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F 1.40 _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 29.130 _refine.ls_d_res_high 1.903 _refine.ls_percent_reflns_obs 99.02 _refine.ls_R_factor_obs 0.1658 _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work 0.1614 _refine.ls_R_factor_R_free 0.1860 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 5.05 _refine.ls_number_reflns_R_free 3879 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc ? _refine.correlation_coeff_Fo_to_Fc_free ? _refine.B_iso_mean ? _refine.aniso_B[1][1] ? _refine.aniso_B[2][2] ? _refine.aniso_B[3][3] ? _refine.aniso_B[1][2] ? _refine.aniso_B[1][3] ? _refine.aniso_B[2][3] ? _refine.solvent_model_details 'FLAT BULK SOLVENT MODEL' _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.11 _refine.pdbx_solvent_ion_probe_radii ? _refine.pdbx_solvent_shrinkage_radii 0.90 _refine.pdbx_ls_cross_valid_method ? _refine.details ? _refine.pdbx_starting_model 'PDB ENTRY 3G7T' _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values TWIN_LSQ_F _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R ? _refine.pdbx_overall_ESU_R_Free ? _refine.overall_SU_ML . _refine.pdbx_overall_phase_error 28.80 _refine.overall_SU_B ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_diffrn_id 1 _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 5944 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 33 _refine_hist.number_atoms_solvent 666 _refine_hist.number_atoms_total 6643 _refine_hist.d_res_high 1.903 _refine_hist.d_res_low 29.130 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_restraint_function _refine_ls_restr.pdbx_refine_id f_bond_d 0.012 ? ? 6133 ? 'X-RAY DIFFRACTION' f_angle_d 1.295 ? ? 8291 ? 'X-RAY DIFFRACTION' f_dihedral_angle_d 17.085 ? ? 2245 ? 'X-RAY DIFFRACTION' f_chiral_restr 0.067 ? ? 992 ? 'X-RAY DIFFRACTION' f_plane_restr 0.005 ? ? 1039 ? 'X-RAY DIFFRACTION' # loop_ _refine_ls_shell.pdbx_total_number_of_bins_used _refine_ls_shell.d_res_high _refine_ls_shell.d_res_low _refine_ls_shell.number_reflns_R_work _refine_ls_shell.R_factor_R_work _refine_ls_shell.percent_reflns_obs _refine_ls_shell.R_factor_R_free _refine_ls_shell.R_factor_R_free_error _refine_ls_shell.percent_reflns_R_free _refine_ls_shell.number_reflns_R_free _refine_ls_shell.number_reflns_all _refine_ls_shell.R_factor_all _refine_ls_shell.number_reflns_obs _refine_ls_shell.redundancy_reflns_obs _refine_ls_shell.pdbx_refine_id . 1.9030 1.9358 3534 0.2462 91.00 0.2674 . . 173 . . . . 'X-RAY DIFFRACTION' . 1.9358 1.9709 3594 0.2232 94.00 0.2026 . . 180 . . . . 'X-RAY DIFFRACTION' . 1.9709 2.0088 3634 0.2122 94.00 0.2328 . . 190 . . . . 'X-RAY DIFFRACTION' . 2.0088 2.0498 3640 0.1964 94.00 0.2150 . . 174 . . . . 'X-RAY DIFFRACTION' . 2.0498 2.0944 3664 0.1986 94.00 0.2242 . . 190 . . . . 'X-RAY DIFFRACTION' . 2.0944 2.1431 3611 0.1881 94.00 0.2026 . . 198 . . . . 'X-RAY DIFFRACTION' . 2.1431 2.1966 3648 0.1889 95.00 0.2077 . . 187 . . . . 'X-RAY DIFFRACTION' . 2.1966 2.2560 3670 0.1820 94.00 0.2103 . . 209 . . . . 'X-RAY DIFFRACTION' . 2.2560 2.3224 3677 0.1850 95.00 0.1872 . . 190 . . . . 'X-RAY DIFFRACTION' . 2.3224 2.3973 3691 0.1867 95.00 0.1817 . . 187 . . . . 'X-RAY DIFFRACTION' . 2.3973 2.4829 3687 0.1827 95.00 0.2119 . . 202 . . . . 'X-RAY DIFFRACTION' . 2.4829 2.5822 3667 0.1763 94.00 0.2060 . . 209 . . . . 'X-RAY DIFFRACTION' . 2.5822 2.6996 3654 0.1823 95.00 0.1884 . . 181 . . . . 'X-RAY DIFFRACTION' . 2.6996 2.8418 3685 0.1702 95.00 0.2073 . . 208 . . . . 'X-RAY DIFFRACTION' . 2.8418 3.0196 3687 0.1660 95.00 0.1908 . . 187 . . . . 'X-RAY DIFFRACTION' . 3.0196 3.2523 3711 0.1532 95.00 0.1875 . . 191 . . . . 'X-RAY DIFFRACTION' . 3.2523 3.5789 3658 0.1453 95.00 0.1688 . . 191 . . . . 'X-RAY DIFFRACTION' . 3.5789 4.0951 3672 0.1313 94.00 0.1556 . . 210 . . . . 'X-RAY DIFFRACTION' . 4.0951 5.1529 3645 0.1213 94.00 0.1660 . . 184 . . . . 'X-RAY DIFFRACTION' . 5.1529 26.1827 3559 0.1748 91.00 0.1986 . . 216 . . . . 'X-RAY DIFFRACTION' # _struct.entry_id 4GSX _struct.title 'High resolution structure of dengue virus serotype 1 sE containing stem' _struct.pdbx_descriptor 'Envelope protein E' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 4GSX _struct_keywords.pdbx_keywords 'VIRAL PROTEIN' _struct_keywords.text 'Viral Fusion Protein, VIRAL PROTEIN' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 1 ? C N N 2 ? D N N 3 ? E N N 3 ? F N N 4 ? G N N 2 ? H N N 3 ? I N N 3 ? J N N 5 ? K N N 5 ? # _struct_biol.id 1 _struct_biol.details ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 GLY A 23 ? ARG A 25 ? GLY A 7 ARG A 9 5 ? 3 HELX_P HELX_P2 2 LEU A 98 ? ASP A 103 ? LEU A 82 ASP A 87 5 ? 6 HELX_P HELX_P3 3 GLY A 116 ? GLY A 120 ? GLY A 100 GLY A 104 5 ? 5 HELX_P HELX_P4 4 GLN A 147 ? GLU A 149 ? GLN A 131 GLU A 133 5 ? 3 HELX_P HELX_P5 5 LYS A 226 ? ASP A 231 ? LYS A 210 ASP A 215 1 ? 6 HELX_P HELX_P6 6 ARG A 249 ? LEU A 252 ? ARG A 233 LEU A 236 5 ? 4 HELX_P HELX_P7 7 GLN A 272 ? LEU A 280 ? GLN A 256 LEU A 264 1 ? 9 HELX_P HELX_P8 8 ALA A 398 ? ALA A 402 ? ALA A 382 ALA A 386 5 ? 5 HELX_P HELX_P9 9 GLY B 23 ? ARG B 25 ? GLY B 7 ARG B 9 5 ? 3 HELX_P HELX_P10 10 LEU B 98 ? GLN B 102 ? LEU B 82 GLN B 86 5 ? 5 HELX_P HELX_P11 11 GLN B 147 ? GLU B 149 ? GLN B 131 GLU B 133 5 ? 3 HELX_P HELX_P12 12 LYS B 226 ? ASP B 231 ? LYS B 210 ASP B 215 1 ? 6 HELX_P HELX_P13 13 ARG B 249 ? LEU B 252 ? ARG B 233 LEU B 236 5 ? 4 HELX_P HELX_P14 14 GLN B 272 ? THR B 281 ? GLN B 256 THR B 265 1 ? 10 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 19 SG ? ? ? 1_555 A CYS 46 SG ? ? A CYS 3 A CYS 30 1_555 ? ? ? ? ? ? ? 2.029 ? disulf2 disulf ? ? A CYS 76 SG ? ? ? 1_555 A CYS 137 SG ? ? A CYS 60 A CYS 121 1_555 ? ? ? ? ? ? ? 2.061 ? disulf3 disulf ? ? A CYS 90 SG ? ? ? 1_555 A CYS 121 SG ? ? A CYS 74 A CYS 105 1_555 ? ? ? ? ? ? ? 2.041 ? disulf4 disulf ? ? A CYS 108 SG ? ? ? 1_555 A CYS 132 SG ? ? A CYS 92 A CYS 116 1_555 ? ? ? ? ? ? ? 2.044 ? disulf5 disulf ? ? A CYS 201 SG ? ? ? 1_555 A CYS 301 SG ? ? A CYS 185 A CYS 285 1_555 ? ? ? ? ? ? ? 2.040 ? disulf6 disulf ? ? A CYS 318 SG ? ? ? 1_555 A CYS 349 SG ? ? A CYS 302 A CYS 333 1_555 ? ? ? ? ? ? ? 2.048 ? disulf7 disulf ? ? B CYS 19 SG ? ? ? 1_555 B CYS 46 SG ? ? B CYS 3 B CYS 30 1_555 ? ? ? ? ? ? ? 2.035 ? disulf8 disulf ? ? B CYS 76 SG ? ? ? 1_555 B CYS 137 SG ? ? B CYS 60 B CYS 121 1_555 ? ? ? ? ? ? ? 2.061 ? disulf9 disulf ? ? B CYS 90 SG ? ? ? 1_555 B CYS 121 SG ? ? B CYS 74 B CYS 105 1_555 ? ? ? ? ? ? ? 2.025 ? disulf10 disulf ? ? B CYS 108 SG ? ? ? 1_555 B CYS 132 SG ? ? B CYS 92 B CYS 116 1_555 ? ? ? ? ? ? ? 2.029 ? disulf11 disulf ? ? B CYS 201 SG ? ? ? 1_555 B CYS 301 SG ? ? B CYS 185 B CYS 285 1_555 ? ? ? ? ? ? ? 2.007 ? disulf12 disulf ? ? B CYS 318 SG ? ? ? 1_555 B CYS 349 SG ? ? B CYS 302 B CYS 333 1_555 ? ? ? ? ? ? ? 2.046 ? metalc1 metalc ? ? I CD . CD ? ? ? 1_555 K HOH . O ? ? B CD 503 B HOH 789 1_555 ? ? ? ? ? ? ? 2.387 ? metalc2 metalc ? ? B HIS 298 NE2 ? ? ? 1_555 I CD . CD ? ? B HIS 282 B CD 503 1_555 ? ? ? ? ? ? ? 2.424 ? metalc3 metalc ? ? B GLU 327 OE1 ? ? ? 1_555 D CD . CD ? ? B GLU 311 A CD 502 1_555 ? ? ? ? ? ? ? 2.429 ? metalc4 metalc ? ? B GLU 327 OE2 ? ? ? 1_555 D CD . CD ? ? B GLU 311 A CD 502 1_555 ? ? ? ? ? ? ? 2.454 ? metalc5 metalc ? ? A ASP 114 OD2 ? ? ? 1_555 D CD . CD ? ? A ASP 98 A CD 502 1_555 ? ? ? ? ? ? ? 2.455 ? metalc6 metalc ? ? B HIS 43 NE2 ? ? ? 1_555 I CD . CD ? ? B HIS 27 B CD 503 1_555 ? ? ? ? ? ? ? 2.479 ? metalc7 metalc ? ? A ASP 26 OD1 ? ? ? 1_555 E CD . CD ? ? A ASP 10 A CD 503 1_555 ? ? ? ? ? ? ? 2.516 ? metalc8 metalc ? ? B ASP 26 OD1 ? ? ? 1_555 H CD . CD ? ? B ASP 10 B CD 502 1_555 ? ? ? ? ? ? ? 2.523 ? metalc9 metalc ? ? A ASP 26 OD2 ? ? ? 1_555 E CD . CD ? ? A ASP 10 A CD 503 1_555 ? ? ? ? ? ? ? 2.572 ? metalc10 metalc ? ? E CD . CD ? ? ? 1_555 J HOH . O ? ? A CD 503 A HOH 623 1_555 ? ? ? ? ? ? ? 2.598 ? metalc11 metalc ? ? E CD . CD ? ? ? 1_555 J HOH . O ? ? A CD 503 A HOH 932 1_555 ? ? ? ? ? ? ? 2.618 ? metalc12 metalc ? ? B ASP 26 OD2 ? ? ? 1_555 H CD . CD ? ? B ASP 10 B CD 502 1_555 ? ? ? ? ? ? ? 2.649 ? metalc13 metalc ? ? D CD . CD ? ? ? 1_555 J HOH . O ? ? A CD 502 A HOH 710 1_555 ? ? ? ? ? ? ? 2.671 ? covale1 covale ? ? A ASN 83 ND2 ? ? ? 1_555 C NAG . C1 ? ? A ASN 67 A NAG 501 1_555 ? ? ? ? ? ? ? 1.839 ? covale2 covale ? ? B ASN 83 ND2 ? ? ? 1_555 G NAG . C1 ? ? B ASN 67 B NAG 501 1_555 ? ? ? ? ? ? ? 1.795 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? metalc ? ? covale ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 ALA 347 A . ? ALA 331 A PRO 348 A ? PRO 332 A 1 5.05 2 ALA 347 B . ? ALA 331 B PRO 348 B ? PRO 332 B 1 8.13 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 10 ? B ? 9 ? C ? 5 ? D ? 2 ? E ? 3 ? F ? 3 ? G ? 2 ? H ? 3 ? I ? 5 ? J ? 5 ? K ? 5 ? L ? 4 ? M ? 5 ? N ? 2 ? O ? 3 ? P ? 3 ? Q ? 2 ? R ? 3 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? parallel A 2 3 ? anti-parallel A 3 4 ? anti-parallel A 4 5 ? anti-parallel A 5 6 ? anti-parallel A 6 7 ? anti-parallel A 7 8 ? anti-parallel A 9 10 ? anti-parallel B 1 2 ? anti-parallel B 2 3 ? anti-parallel B 3 4 ? anti-parallel B 4 5 ? anti-parallel B 5 6 ? anti-parallel B 6 7 ? anti-parallel B 8 9 ? anti-parallel C 1 2 ? anti-parallel C 2 3 ? anti-parallel C 3 4 ? anti-parallel C 4 5 ? anti-parallel D 1 2 ? anti-parallel E 1 2 ? anti-parallel E 2 3 ? anti-parallel F 1 2 ? anti-parallel F 2 3 ? anti-parallel G 1 2 ? anti-parallel H 1 2 ? anti-parallel H 2 3 ? anti-parallel I 1 2 ? parallel I 2 3 ? anti-parallel I 3 4 ? anti-parallel I 4 5 ? anti-parallel J 1 2 ? parallel J 2 3 ? anti-parallel J 3 4 ? anti-parallel J 4 5 ? anti-parallel K 1 2 ? anti-parallel K 2 3 ? anti-parallel K 3 4 ? anti-parallel K 4 5 ? anti-parallel L 1 2 ? anti-parallel L 2 3 ? anti-parallel L 3 4 ? anti-parallel M 1 2 ? anti-parallel M 2 3 ? anti-parallel M 3 4 ? anti-parallel M 4 5 ? anti-parallel N 1 2 ? anti-parallel O 1 2 ? anti-parallel O 2 3 ? anti-parallel P 1 2 ? anti-parallel P 2 3 ? anti-parallel Q 1 2 ? anti-parallel R 1 2 ? anti-parallel R 2 3 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 VAL A 20 ? GLY A 21 ? VAL A 4 GLY A 5 A 2 VAL A 47 ? THR A 49 ? VAL A 31 THR A 33 A 3 LEU A 57 ? THR A 67 ? LEU A 41 THR A 51 A 4 THR A 292 ? PHE A 295 ? THR A 276 PHE A 279 A 5 THR A 284 ? SER A 289 ? THR A 268 SER A 273 A 6 LYS A 220 ? HIS A 225 ? LYS A 204 HIS A 209 A 7 MET A 212 ? MET A 217 ? MET A 196 MET A 201 A 8 GLY A 125 ? ILE A 145 ? GLY A 109 ILE A 129 A 9 LEU A 151 ? VAL A 159 ? LEU A 135 VAL A 143 A 10 THR A 176 ? ILE A 180 ? THR A 160 ILE A 164 B 1 PHE A 106 ? ARG A 115 ? PHE A 90 ARG A 99 B 2 GLY A 125 ? ILE A 145 ? GLY A 109 ILE A 129 B 3 MET A 212 ? MET A 217 ? MET A 196 MET A 201 B 4 LYS A 220 ? HIS A 225 ? LYS A 204 HIS A 209 B 5 THR A 284 ? SER A 289 ? THR A 268 SER A 273 B 6 THR A 292 ? PHE A 295 ? THR A 276 PHE A 279 B 7 LEU A 57 ? THR A 67 ? LEU A 41 THR A 51 B 8 ALA A 70 ? SER A 88 ? ALA A 54 SER A 72 B 9 TRP A 236 ? SER A 238 ? TRP A 220 SER A 222 C 1 PHE A 27 ? GLU A 29 ? PHE A 11 GLU A 13 C 2 ALA A 34 ? GLU A 42 ? ALA A 18 GLU A 26 C 3 HIS A 298 ? ASP A 306 ? HIS A 282 ASP A 290 C 4 GLY A 195 ? PRO A 203 ? GLY A 179 PRO A 187 C 5 THR A 186 ? LEU A 191 ? THR A 170 LEU A 175 D 1 VAL A 254 ? PHE A 256 ? VAL A 238 PHE A 240 D 2 VAL A 266 ? VAL A 268 ? VAL A 250 VAL A 252 E 1 PHE A 322 ? LEU A 324 ? PHE A 306 LEU A 308 E 2 VAL A 336 ? TYR A 342 ? VAL A 320 TYR A 326 E 3 ALA A 329 ? GLU A 330 ? ALA A 313 GLU A 314 F 1 PHE A 322 ? LEU A 324 ? PHE A 306 LEU A 308 F 2 VAL A 336 ? TYR A 342 ? VAL A 320 TYR A 326 F 3 VAL A 381 ? ALA A 385 ? VAL A 365 ALA A 369 G 1 CYS A 349 ? LYS A 350 ? CYS A 333 LYS A 334 G 2 ILE A 373 ? VAL A 374 ? ILE A 357 VAL A 358 H 1 PHE A 353 ? ASP A 357 ? PHE A 337 ASP A 341 H 2 GLY A 390 ? VAL A 396 ? GLY A 374 VAL A 380 H 3 LEU A 403 ? LYS A 409 ? LEU A 387 LYS A 393 I 1 CYS B 19 ? GLY B 21 ? CYS B 3 GLY B 5 I 2 CYS B 46 ? MET B 50 ? CYS B 30 MET B 34 I 3 THR B 56 ? THR B 67 ? THR B 40 THR B 51 I 4 LEU B 151 ? VAL B 159 ? LEU B 135 VAL B 143 I 5 THR B 176 ? ILE B 180 ? THR B 160 ILE B 164 J 1 CYS B 19 ? GLY B 21 ? CYS B 3 GLY B 5 J 2 CYS B 46 ? MET B 50 ? CYS B 30 MET B 34 J 3 THR B 56 ? THR B 67 ? THR B 40 THR B 51 J 4 THR B 292 ? PHE B 295 ? THR B 276 PHE B 279 J 5 THR B 288 ? SER B 289 ? THR B 272 SER B 273 K 1 PHE B 27 ? GLU B 29 ? PHE B 11 GLU B 13 K 2 ALA B 34 ? GLU B 42 ? ALA B 18 GLU B 26 K 3 HIS B 298 ? ASP B 306 ? HIS B 282 ASP B 290 K 4 GLY B 195 ? PRO B 203 ? GLY B 179 PRO B 187 K 5 THR B 186 ? LEU B 191 ? THR B 170 LEU B 175 L 1 PHE B 106 ? ASP B 114 ? PHE B 90 ASP B 98 L 2 LYS B 126 ? ILE B 145 ? LYS B 110 ILE B 129 L 3 ALA B 70 ? SER B 88 ? ALA B 54 SER B 72 L 4 TRP B 236 ? SER B 238 ? TRP B 220 SER B 222 M 1 PHE B 106 ? ASP B 114 ? PHE B 90 ASP B 98 M 2 LYS B 126 ? ILE B 145 ? LYS B 110 ILE B 129 M 3 MET B 212 ? MET B 217 ? MET B 196 MET B 201 M 4 LYS B 220 ? HIS B 225 ? LYS B 204 HIS B 209 M 5 GLU B 285 ? ILE B 286 ? GLU B 269 ILE B 270 N 1 VAL B 254 ? PHE B 256 ? VAL B 238 PHE B 240 N 2 VAL B 266 ? VAL B 268 ? VAL B 250 VAL B 252 O 1 PHE B 322 ? LEU B 324 ? PHE B 306 LEU B 308 O 2 VAL B 336 ? TYR B 342 ? VAL B 320 TYR B 326 O 3 ALA B 329 ? GLU B 330 ? ALA B 313 GLU B 314 P 1 PHE B 322 ? LEU B 324 ? PHE B 306 LEU B 308 P 2 VAL B 336 ? TYR B 342 ? VAL B 320 TYR B 326 P 3 VAL B 381 ? ALA B 385 ? VAL B 365 ALA B 369 Q 1 CYS B 349 ? LYS B 350 ? CYS B 333 LYS B 334 Q 2 ILE B 373 ? VAL B 374 ? ILE B 357 VAL B 358 R 1 PHE B 353 ? ASP B 357 ? PHE B 337 ASP B 341 R 2 GLY B 390 ? VAL B 396 ? GLY B 374 VAL B 380 R 3 LEU B 403 ? LYS B 409 ? LEU B 387 LYS B 393 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 N VAL A 20 ? N VAL A 4 O THR A 48 ? O THR A 32 A 2 3 N THR A 49 ? N THR A 33 O LEU A 57 ? O LEU A 41 A 3 4 N VAL A 66 ? N VAL A 50 O THR A 293 ? O THR A 277 A 4 5 O ILE A 294 ? O ILE A 278 N GLN A 287 ? N GLN A 271 A 5 6 O THR A 284 ? O THR A 268 N LEU A 223 ? N LEU A 207 A 6 7 O VAL A 224 ? O VAL A 208 N VAL A 213 ? N VAL A 197 A 7 8 O LEU A 214 ? O LEU A 198 N LYS A 144 ? N LYS A 128 A 9 10 N VAL A 155 ? N VAL A 139 O ALA A 178 ? O ALA A 162 B 1 2 N VAL A 113 ? N VAL A 97 O GLY A 127 ? O GLY A 111 B 2 3 N LYS A 144 ? N LYS A 128 O LEU A 214 ? O LEU A 198 B 3 4 N VAL A 213 ? N VAL A 197 O VAL A 224 ? O VAL A 208 B 4 5 N LEU A 223 ? N LEU A 207 O THR A 284 ? O THR A 268 B 5 6 N GLN A 287 ? N GLN A 271 O ILE A 294 ? O ILE A 278 B 6 7 O THR A 293 ? O THR A 277 N VAL A 66 ? N VAL A 50 B 8 9 N LYS A 74 ? N LYS A 58 O THR A 237 ? O THR A 221 C 1 2 N VAL A 28 ? N VAL A 12 O TRP A 36 ? O TRP A 20 C 2 3 N VAL A 39 ? N VAL A 23 O CYS A 301 ? O CYS A 285 C 3 4 O ARG A 302 ? O ARG A 286 N ASP A 200 ? N ASP A 184 C 4 5 O LEU A 199 ? O LEU A 183 N SER A 187 ? N SER A 171 D 1 2 N THR A 255 ? N THR A 239 O VAL A 267 ? O VAL A 251 E 1 2 N LYS A 323 ? N LYS A 307 O LYS A 341 ? O LYS A 325 E 2 3 O LEU A 337 ? O LEU A 321 N ALA A 329 ? N ALA A 313 F 1 2 N LYS A 323 ? N LYS A 307 O LYS A 341 ? O LYS A 325 F 2 3 N VAL A 338 ? N VAL A 322 O ILE A 383 ? O ILE A 367 G 1 2 N CYS A 349 ? N CYS A 333 O VAL A 374 ? O VAL A 358 H 1 2 N GLN A 356 ? N GLN A 340 O TYR A 393 ? O TYR A 377 H 2 3 N GLY A 390 ? N GLY A 374 O LYS A 409 ? O LYS A 393 I 1 2 N VAL B 20 ? N VAL B 4 O THR B 48 ? O THR B 32 I 2 3 N THR B 49 ? N THR B 33 O LEU B 57 ? O LEU B 41 I 3 4 N GLU B 60 ? N GLU B 44 O ILE B 156 ? O ILE B 140 I 4 5 N TYR B 153 ? N TYR B 137 O ILE B 180 ? O ILE B 164 J 1 2 N VAL B 20 ? N VAL B 4 O THR B 48 ? O THR B 32 J 2 3 N THR B 49 ? N THR B 33 O LEU B 57 ? O LEU B 41 J 3 4 N VAL B 66 ? N VAL B 50 O THR B 293 ? O THR B 277 J 4 5 O THR B 292 ? O THR B 276 N SER B 289 ? N SER B 273 K 1 2 N VAL B 28 ? N VAL B 12 O TRP B 36 ? O TRP B 20 K 2 3 N VAL B 39 ? N VAL B 23 O CYS B 301 ? O CYS B 285 K 3 4 O ARG B 302 ? O ARG B 286 N ASP B 200 ? N ASP B 184 K 4 5 O GLY B 195 ? O GLY B 179 N LEU B 191 ? N LEU B 175 L 1 2 N VAL B 113 ? N VAL B 97 O GLY B 127 ? O GLY B 111 L 2 3 O LYS B 134 ? O LYS B 118 N SER B 82 ? N SER B 66 L 3 4 N LYS B 74 ? N LYS B 58 O THR B 237 ? O THR B 221 M 1 2 N VAL B 113 ? N VAL B 97 O GLY B 127 ? O GLY B 111 M 2 3 N LYS B 144 ? N LYS B 128 O LEU B 214 ? O LEU B 198 M 3 4 N VAL B 213 ? N VAL B 197 O VAL B 224 ? O VAL B 208 M 4 5 N SER B 221 ? N SER B 205 O ILE B 286 ? O ILE B 270 N 1 2 N THR B 255 ? N THR B 239 O VAL B 267 ? O VAL B 251 O 1 2 N LYS B 323 ? N LYS B 307 O LYS B 341 ? O LYS B 325 O 2 3 O LEU B 337 ? O LEU B 321 N ALA B 329 ? N ALA B 313 P 1 2 N LYS B 323 ? N LYS B 307 O LYS B 341 ? O LYS B 325 P 2 3 N VAL B 338 ? N VAL B 322 O ILE B 383 ? O ILE B 367 Q 1 2 N CYS B 349 ? N CYS B 333 O VAL B 374 ? O VAL B 358 R 1 2 N GLN B 356 ? N GLN B 340 O TYR B 393 ? O TYR B 377 R 2 3 N ILE B 394 ? N ILE B 378 O LEU B 405 ? O LEU B 389 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE NAG A 501' AC2 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE CD A 502' AC3 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE CD A 503' AC4 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE CL A 504' AC5 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE NAG B 501' AC6 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE CD B 502' AC7 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE CD B 503' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 3 ASN A 83 ? ASN A 67 . ? 1_555 ? 2 AC1 3 HOH J . ? HOH A 733 . ? 1_555 ? 3 AC1 3 HOH J . ? HOH A 896 . ? 1_555 ? 4 AC2 4 THR A 92 ? THR A 76 . ? 2_545 ? 5 AC2 4 ASP A 114 ? ASP A 98 . ? 1_555 ? 6 AC2 4 HOH J . ? HOH A 710 . ? 1_555 ? 7 AC2 4 GLU B 327 ? GLU B 311 . ? 1_555 ? 8 AC3 4 ASP A 26 ? ASP A 10 . ? 1_555 ? 9 AC3 4 HOH J . ? HOH A 623 . ? 1_555 ? 10 AC3 4 HOH J . ? HOH A 777 . ? 1_555 ? 11 AC3 4 HOH J . ? HOH A 932 . ? 1_555 ? 12 AC4 3 GLY A 118 ? GLY A 102 . ? 1_555 ? 13 AC4 3 HOH J . ? HOH A 628 . ? 1_555 ? 14 AC4 3 GLU B 327 ? GLU B 311 . ? 1_555 ? 15 AC5 3 ASN B 83 ? ASN B 67 . ? 1_555 ? 16 AC5 3 LYS B 134 ? LYS B 118 . ? 1_555 ? 17 AC5 3 HOH K . ? HOH B 775 . ? 1_555 ? 18 AC6 2 ASP B 26 ? ASP B 10 . ? 1_555 ? 19 AC6 2 HOH K . ? HOH B 849 . ? 1_555 ? 20 AC7 5 HIS B 43 ? HIS B 27 . ? 1_555 ? 21 AC7 5 HIS B 298 ? HIS B 282 . ? 1_555 ? 22 AC7 5 GLU B 384 ? GLU B 368 . ? 1_555 ? 23 AC7 5 HOH K . ? HOH B 789 . ? 1_555 ? 24 AC7 5 HOH K . ? HOH B 806 . ? 1_555 ? # _database_PDB_matrix.entry_id 4GSX _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 4GSX _atom_sites.fract_transf_matrix[1][1] 0.012891 _atom_sites.fract_transf_matrix[1][2] 0.007443 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.014886 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.003419 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C CD CL N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . ARG A 1 18 ? 11.169 -24.938 55.149 1.00 32.93 ? 2 ARG A N 1 ATOM 2 C CA . ARG A 1 18 ? 11.569 -24.968 53.752 1.00 23.80 ? 2 ARG A CA 1 ATOM 3 C C . ARG A 1 18 ? 13.077 -24.893 53.548 1.00 25.35 ? 2 ARG A C 1 ATOM 4 O O . ARG A 1 18 ? 13.571 -25.293 52.496 1.00 25.43 ? 2 ARG A O 1 ATOM 5 C CB . ARG A 1 18 ? 10.922 -23.825 52.991 1.00 28.51 ? 2 ARG A CB 1 ATOM 6 C CG . ARG A 1 18 ? 11.032 -23.992 51.492 1.00 36.64 ? 2 ARG A CG 1 ATOM 7 C CD . ARG A 1 18 ? 10.248 -22.938 50.745 1.00 42.46 ? 2 ARG A CD 1 ATOM 8 N NE . ARG A 1 18 ? 11.090 -21.809 50.368 1.00 42.92 ? 2 ARG A NE 1 ATOM 9 C CZ . ARG A 1 18 ? 12.082 -21.870 49.481 1.00 38.97 ? 2 ARG A CZ 1 ATOM 10 N NH1 . ARG A 1 18 ? 12.395 -23.007 48.870 1.00 35.73 ? 2 ARG A NH1 1 ATOM 11 N NH2 . ARG A 1 18 ? 12.776 -20.781 49.206 1.00 39.09 ? 2 ARG A NH2 1 ATOM 12 N N . CYS A 1 19 ? 13.811 -24.383 54.536 1.00 24.67 ? 3 CYS A N 1 ATOM 13 C CA . CYS A 1 19 ? 15.255 -24.269 54.397 1.00 17.68 ? 3 CYS A CA 1 ATOM 14 C C . CYS A 1 19 ? 15.916 -25.450 55.022 1.00 15.30 ? 3 CYS A C 1 ATOM 15 O O . CYS A 1 19 ? 15.411 -26.005 55.991 1.00 16.85 ? 3 CYS A O 1 ATOM 16 C CB . CYS A 1 19 ? 15.781 -23.004 55.046 1.00 15.85 ? 3 CYS A CB 1 ATOM 17 S SG . CYS A 1 19 ? 15.251 -21.531 54.204 1.00 22.27 ? 3 CYS A SG 1 ATOM 18 N N . VAL A 1 20 ? 17.058 -25.819 54.452 1.00 17.26 ? 4 VAL A N 1 ATOM 19 C CA . VAL A 1 20 ? 17.911 -26.854 55.001 1.00 13.60 ? 4 VAL A CA 1 ATOM 20 C C . VAL A 1 20 ? 18.850 -26.219 56.017 1.00 12.28 ? 4 VAL A C 1 ATOM 21 O O . VAL A 1 20 ? 19.503 -25.230 55.728 1.00 14.00 ? 4 VAL A O 1 ATOM 22 C CB . VAL A 1 20 ? 18.738 -27.500 53.901 1.00 14.92 ? 4 VAL A CB 1 ATOM 23 C CG1 . VAL A 1 20 ? 19.639 -28.567 54.491 1.00 11.94 ? 4 VAL A CG1 1 ATOM 24 C CG2 . VAL A 1 20 ? 17.822 -28.050 52.846 1.00 17.79 ? 4 VAL A CG2 1 ATOM 25 N N . GLY A 1 21 ? 18.906 -26.781 57.212 1.00 12.39 ? 5 GLY A N 1 ATOM 26 C CA . GLY A 1 21 ? 19.766 -26.256 58.252 1.00 12.36 ? 5 GLY A CA 1 ATOM 27 C C . GLY A 1 21 ? 21.218 -26.603 58.004 1.00 11.13 ? 5 GLY A C 1 ATOM 28 O O . GLY A 1 21 ? 21.533 -27.652 57.456 1.00 12.96 ? 5 GLY A O 1 ATOM 29 N N . ILE A 1 22 ? 22.102 -25.707 58.415 1.00 11.79 ? 6 ILE A N 1 ATOM 30 C CA . ILE A 1 22 ? 23.537 -25.894 58.249 1.00 13.67 ? 6 ILE A CA 1 ATOM 31 C C . ILE A 1 22 ? 24.109 -26.842 59.300 1.00 12.68 ? 6 ILE A C 1 ATOM 32 O O . ILE A 1 22 ? 23.849 -26.683 60.479 1.00 12.63 ? 6 ILE A O 1 ATOM 33 C CB . ILE A 1 22 ? 24.259 -24.529 58.280 1.00 11.87 ? 6 ILE A CB 1 ATOM 34 C CG1 . ILE A 1 22 ? 23.860 -23.738 57.036 1.00 12.30 ? 6 ILE A CG1 1 ATOM 35 C CG2 . ILE A 1 22 ? 25.762 -24.700 58.339 1.00 12.76 ? 6 ILE A CG2 1 ATOM 36 C CD1 . ILE A 1 22 ? 24.477 -22.403 56.945 1.00 15.72 ? 6 ILE A CD1 1 ATOM 37 N N . GLY A 1 23 ? 24.875 -27.837 58.860 1.00 11.58 ? 7 GLY A N 1 ATOM 38 C CA . GLY A 1 23 ? 25.403 -28.843 59.762 1.00 11.36 ? 7 GLY A CA 1 ATOM 39 C C . GLY A 1 23 ? 26.684 -28.396 60.424 1.00 10.65 ? 7 GLY A C 1 ATOM 40 O O . GLY A 1 23 ? 27.363 -27.517 59.912 1.00 10.09 ? 7 GLY A O 1 ATOM 41 N N . ASN A 1 24 ? 27.044 -28.999 61.549 1.00 12.09 ? 8 ASN A N 1 ATOM 42 C CA . ASN A 1 24 ? 28.195 -28.475 62.284 1.00 13.91 ? 8 ASN A CA 1 ATOM 43 C C . ASN A 1 24 ? 29.525 -28.757 61.584 1.00 10.33 ? 8 ASN A C 1 ATOM 44 O O . ASN A 1 24 ? 30.530 -28.157 61.919 1.00 10.82 ? 8 ASN A O 1 ATOM 45 C CB . ASN A 1 24 ? 28.195 -28.902 63.758 1.00 17.47 ? 8 ASN A CB 1 ATOM 46 C CG . ASN A 1 24 ? 28.233 -30.396 63.944 1.00 23.51 ? 8 ASN A CG 1 ATOM 47 O OD1 . ASN A 1 24 ? 28.551 -31.144 63.022 1.00 29.67 ? 8 ASN A OD1 1 ATOM 48 N ND2 . ASN A 1 24 ? 27.912 -30.846 65.158 1.00 30.42 ? 8 ASN A ND2 1 ATOM 49 N N . ARG A 1 25 ? 29.504 -29.614 60.566 1.00 10.95 ? 9 ARG A N 1 ATOM 50 C CA . ARG A 1 25 ? 30.685 -29.871 59.739 1.00 10.50 ? 9 ARG A CA 1 ATOM 51 C C . ARG A 1 25 ? 30.941 -28.766 58.719 1.00 7.87 ? 9 ARG A C 1 ATOM 52 O O . ARG A 1 25 ? 32.009 -28.697 58.125 1.00 7.81 ? 9 ARG A O 1 ATOM 53 C CB . ARG A 1 25 ? 30.563 -31.217 59.031 1.00 13.17 ? 9 ARG A CB 1 ATOM 54 C CG . ARG A 1 25 ? 31.431 -32.276 59.660 1.00 13.88 ? 9 ARG A CG 1 ATOM 55 C CD . ARG A 1 25 ? 30.761 -33.624 59.804 1.00 15.68 ? 9 ARG A CD 1 ATOM 56 N NE . ARG A 1 25 ? 29.692 -33.877 58.842 1.00 17.29 ? 9 ARG A NE 1 ATOM 57 C CZ . ARG A 1 25 ? 29.856 -34.329 57.608 1.00 16.32 ? 9 ARG A CZ 1 ATOM 58 N NH1 . ARG A 1 25 ? 31.054 -34.584 57.137 1.00 17.69 ? 9 ARG A NH1 1 ATOM 59 N NH2 . ARG A 1 25 ? 28.809 -34.531 56.840 1.00 18.73 ? 9 ARG A NH2 1 ATOM 60 N N . ASP A 1 26 ? 29.980 -27.868 58.572 1.00 7.88 ? 10 ASP A N 1 ATOM 61 C CA . ASP A 1 26 ? 30.061 -26.854 57.560 1.00 7.48 ? 10 ASP A CA 1 ATOM 62 C C . ASP A 1 26 ? 30.406 -25.503 58.123 1.00 6.87 ? 10 ASP A C 1 ATOM 63 O O . ASP A 1 26 ? 30.325 -24.526 57.404 1.00 10.74 ? 10 ASP A O 1 ATOM 64 C CB . ASP A 1 26 ? 28.747 -26.786 56.802 1.00 10.68 ? 10 ASP A CB 1 ATOM 65 C CG . ASP A 1 26 ? 28.688 -27.790 55.676 1.00 14.07 ? 10 ASP A CG 1 ATOM 66 O OD1 . ASP A 1 26 ? 29.686 -27.891 54.939 1.00 17.09 ? 10 ASP A OD1 1 ATOM 67 O OD2 . ASP A 1 26 ? 27.675 -28.490 55.534 1.00 16.87 ? 10 ASP A OD2 1 ATOM 68 N N . PHE A 1 27 ? 30.807 -25.426 59.388 1.00 6.33 ? 11 PHE A N 1 ATOM 69 C CA . PHE A 1 27 ? 31.345 -24.178 59.899 1.00 7.21 ? 11 PHE A CA 1 ATOM 70 C C . PHE A 1 27 ? 32.453 -24.393 60.908 1.00 6.60 ? 11 PHE A C 1 ATOM 71 O O . PHE A 1 27 ? 32.638 -25.479 61.430 1.00 7.85 ? 11 PHE A O 1 ATOM 72 C CB . PHE A 1 27 ? 30.256 -23.252 60.466 1.00 7.35 ? 11 PHE A CB 1 ATOM 73 C CG . PHE A 1 27 ? 29.698 -23.690 61.793 1.00 8.71 ? 11 PHE A CG 1 ATOM 74 C CD1 . PHE A 1 27 ? 28.595 -24.507 61.853 1.00 9.11 ? 11 PHE A CD1 1 ATOM 75 C CD2 . PHE A 1 27 ? 30.255 -23.248 62.970 1.00 8.59 ? 11 PHE A CD2 1 ATOM 76 C CE1 . PHE A 1 27 ? 28.088 -24.895 63.043 1.00 8.16 ? 11 PHE A CE1 1 ATOM 77 C CE2 . PHE A 1 27 ? 29.741 -23.641 64.160 1.00 11.03 ? 11 PHE A CE2 1 ATOM 78 C CZ . PHE A 1 27 ? 28.658 -24.466 64.196 1.00 9.42 ? 11 PHE A CZ 1 ATOM 79 N N . VAL A 1 28 ? 33.226 -23.342 61.124 1.00 7.83 ? 12 VAL A N 1 ATOM 80 C CA . VAL A 1 28 ? 34.155 -23.288 62.229 1.00 7.44 ? 12 VAL A CA 1 ATOM 81 C C . VAL A 1 28 ? 34.018 -21.925 62.870 1.00 6.83 ? 12 VAL A C 1 ATOM 82 O O . VAL A 1 28 ? 34.009 -20.919 62.185 1.00 7.80 ? 12 VAL A O 1 ATOM 83 C CB . VAL A 1 28 ? 35.624 -23.523 61.789 1.00 8.53 ? 12 VAL A CB 1 ATOM 84 C CG1 . VAL A 1 28 ? 35.790 -24.881 61.166 1.00 7.65 ? 12 VAL A CG1 1 ATOM 85 C CG2 . VAL A 1 28 ? 36.063 -22.469 60.829 1.00 9.83 ? 12 VAL A CG2 1 ATOM 86 N N . GLU A 1 29 ? 33.870 -21.905 64.188 1.00 7.51 ? 13 GLU A N 1 ATOM 87 C CA . GLU A 1 29 ? 34.071 -20.696 64.981 1.00 8.16 ? 13 GLU A CA 1 ATOM 88 C C . GLU A 1 29 ? 35.526 -20.651 65.428 1.00 6.70 ? 13 GLU A C 1 ATOM 89 O O . GLU A 1 29 ? 36.019 -21.581 66.026 1.00 9.12 ? 13 GLU A O 1 ATOM 90 C CB . GLU A 1 29 ? 33.144 -20.693 66.216 1.00 7.56 ? 13 GLU A CB 1 ATOM 91 C CG . GLU A 1 29 ? 33.216 -19.412 67.045 1.00 8.88 ? 13 GLU A CG 1 ATOM 92 C CD . GLU A 1 29 ? 32.630 -19.556 68.425 1.00 10.44 ? 13 GLU A CD 1 ATOM 93 O OE1 . GLU A 1 29 ? 32.586 -18.571 69.173 1.00 12.90 ? 13 GLU A OE1 1 ATOM 94 O OE2 . GLU A 1 29 ? 32.192 -20.650 68.780 1.00 15.20 ? 13 GLU A OE2 1 ATOM 95 N N . GLY A 1 30 ? 36.227 -19.576 65.136 1.00 5.74 ? 14 GLY A N 1 ATOM 96 C CA . GLY A 1 30 ? 37.587 -19.466 65.591 1.00 8.24 ? 14 GLY A CA 1 ATOM 97 C C . GLY A 1 30 ? 37.666 -19.305 67.103 1.00 11.16 ? 14 GLY A C 1 ATOM 98 O O . GLY A 1 30 ? 36.733 -18.816 67.728 1.00 11.58 ? 14 GLY A O 1 ATOM 99 N N . LEU A 1 31 ? 38.766 -19.742 67.696 1.00 9.15 ? 15 LEU A N 1 ATOM 100 C CA . LEU A 1 31 ? 39.065 -19.377 69.059 1.00 11.58 ? 15 LEU A CA 1 ATOM 101 C C . LEU A 1 31 ? 39.183 -17.874 69.024 1.00 13.68 ? 15 LEU A C 1 ATOM 102 O O . LEU A 1 31 ? 38.698 -17.176 69.912 1.00 14.27 ? 15 LEU A O 1 ATOM 103 C CB . LEU A 1 31 ? 40.376 -19.984 69.500 1.00 8.85 ? 15 LEU A CB 1 ATOM 104 C CG . LEU A 1 31 ? 40.662 -20.152 70.979 1.00 13.36 ? 15 LEU A CG 1 ATOM 105 C CD1 . LEU A 1 31 ? 42.123 -19.768 71.221 1.00 12.32 ? 15 LEU A CD1 1 ATOM 106 C CD2 . LEU A 1 31 ? 39.688 -19.381 71.893 1.00 11.85 ? 15 LEU A CD2 1 ATOM 107 N N . SER A 1 32 ? 39.852 -17.372 67.993 1.00 11.44 ? 16 SER A N 1 ATOM 108 C CA . SER A 1 32 ? 39.827 -15.942 67.689 1.00 12.42 ? 16 SER A CA 1 ATOM 109 C C . SER A 1 32 ? 39.568 -15.708 66.190 1.00 10.08 ? 16 SER A C 1 ATOM 110 O O . SER A 1 32 ? 39.656 -16.617 65.371 1.00 10.37 ? 16 SER A O 1 ATOM 111 C CB . SER A 1 32 ? 41.121 -15.247 68.149 1.00 8.91 ? 16 SER A CB 1 ATOM 112 O OG . SER A 1 32 ? 42.202 -15.489 67.262 1.00 14.62 ? 16 SER A OG 1 ATOM 113 N N . GLY A 1 33 ? 39.232 -14.484 65.830 1.00 10.43 ? 17 GLY A N 1 ATOM 114 C CA . GLY A 1 33 ? 38.939 -14.195 64.449 1.00 10.60 ? 17 GLY A CA 1 ATOM 115 C C . GLY A 1 33 ? 37.475 -14.343 64.118 1.00 9.47 ? 17 GLY A C 1 ATOM 116 O O . GLY A 1 33 ? 36.636 -13.726 64.756 1.00 13.41 ? 17 GLY A O 1 ATOM 117 N N . ALA A 1 34 ? 37.167 -15.159 63.122 1.00 7.34 ? 18 ALA A N 1 ATOM 118 C CA . ALA A 1 34 ? 35.839 -15.189 62.552 1.00 6.69 ? 18 ALA A CA 1 ATOM 119 C C . ALA A 1 34 ? 35.075 -16.468 62.850 1.00 5.31 ? 18 ALA A C 1 ATOM 120 O O . ALA A 1 34 ? 35.575 -17.377 63.447 1.00 7.84 ? 18 ALA A O 1 ATOM 121 C CB . ALA A 1 34 ? 35.951 -15.001 61.042 1.00 8.40 ? 18 ALA A CB 1 ATOM 122 N N . THR A 1 35 ? 33.825 -16.505 62.429 1.00 8.72 ? 19 THR A N 1 ATOM 123 C CA . THR A 1 35 ? 33.147 -17.756 62.160 1.00 7.33 ? 19 THR A CA 1 ATOM 124 C C . THR A 1 35 ? 33.054 -17.854 60.633 1.00 6.97 ? 19 THR A C 1 ATOM 125 O O . THR A 1 35 ? 32.568 -16.942 59.979 1.00 6.77 ? 19 THR A O 1 ATOM 126 C CB . THR A 1 35 ? 31.744 -17.793 62.801 1.00 8.28 ? 19 THR A CB 1 ATOM 127 O OG1 . THR A 1 35 ? 31.865 -17.990 64.213 1.00 9.17 ? 19 THR A OG1 1 ATOM 128 C CG2 . THR A 1 35 ? 30.918 -18.929 62.245 1.00 7.94 ? 19 THR A CG2 1 ATOM 129 N N . TRP A 1 36 ? 33.579 -18.935 60.073 1.00 7.44 ? 20 TRP A N 1 ATOM 130 C CA . TRP A 1 36 ? 33.484 -19.206 58.636 1.00 6.69 ? 20 TRP A CA 1 ATOM 131 C C . TRP A 1 36 ? 32.470 -20.346 58.365 1.00 6.32 ? 20 TRP A C 1 ATOM 132 O O . TRP A 1 36 ? 32.438 -21.342 59.075 1.00 6.79 ? 20 TRP A O 1 ATOM 133 C CB . TRP A 1 36 ? 34.860 -19.558 58.098 1.00 4.92 ? 20 TRP A CB 1 ATOM 134 C CG . TRP A 1 36 ? 35.785 -18.391 58.019 1.00 5.40 ? 20 TRP A CG 1 ATOM 135 C CD1 . TRP A 1 36 ? 35.471 -17.085 58.207 1.00 5.71 ? 20 TRP A CD1 1 ATOM 136 C CD2 . TRP A 1 36 ? 37.177 -18.419 57.697 1.00 4.60 ? 20 TRP A CD2 1 ATOM 137 N NE1 . TRP A 1 36 ? 36.576 -16.295 58.018 1.00 5.14 ? 20 TRP A NE1 1 ATOM 138 C CE2 . TRP A 1 36 ? 37.639 -17.094 57.718 1.00 7.40 ? 20 TRP A CE2 1 ATOM 139 C CE3 . TRP A 1 36 ? 38.080 -19.437 57.402 1.00 5.36 ? 20 TRP A CE3 1 ATOM 140 C CZ2 . TRP A 1 36 ? 38.955 -16.760 57.428 1.00 5.93 ? 20 TRP A CZ2 1 ATOM 141 C CZ3 . TRP A 1 36 ? 39.380 -19.100 57.147 1.00 5.80 ? 20 TRP A CZ3 1 ATOM 142 C CH2 . TRP A 1 36 ? 39.807 -17.776 57.165 1.00 4.89 ? 20 TRP A CH2 1 ATOM 143 N N . VAL A 1 37 ? 31.626 -20.170 57.357 1.00 6.15 ? 21 VAL A N 1 ATOM 144 C CA . VAL A 1 37 ? 30.544 -21.104 57.052 1.00 5.86 ? 21 VAL A CA 1 ATOM 145 C C . VAL A 1 37 ? 30.550 -21.434 55.571 1.00 5.80 ? 21 VAL A C 1 ATOM 146 O O . VAL A 1 37 ? 30.615 -20.538 54.745 1.00 6.89 ? 21 VAL A O 1 ATOM 147 C CB . VAL A 1 37 ? 29.176 -20.466 57.353 1.00 6.15 ? 21 VAL A CB 1 ATOM 148 C CG1 . VAL A 1 37 ? 28.058 -21.482 57.238 1.00 4.66 ? 21 VAL A CG1 1 ATOM 149 C CG2 . VAL A 1 37 ? 29.183 -19.821 58.721 1.00 6.83 ? 21 VAL A CG2 1 ATOM 150 N N . ASP A 1 38 ? 30.475 -22.711 55.231 1.00 6.01 ? 22 ASP A N 1 ATOM 151 C CA . ASP A 1 38 ? 30.257 -23.135 53.862 1.00 6.81 ? 22 ASP A CA 1 ATOM 152 C C . ASP A 1 38 ? 28.769 -23.342 53.533 1.00 9.66 ? 22 ASP A C 1 ATOM 153 O O . ASP A 1 38 ? 28.072 -24.058 54.241 1.00 9.32 ? 22 ASP A O 1 ATOM 154 C CB . ASP A 1 38 ? 30.947 -24.470 53.614 1.00 8.88 ? 22 ASP A CB 1 ATOM 155 C CG . ASP A 1 38 ? 32.441 -24.356 53.559 1.00 10.52 ? 22 ASP A CG 1 ATOM 156 O OD1 . ASP A 1 38 ? 32.973 -23.239 53.504 1.00 10.12 ? 22 ASP A OD1 1 ATOM 157 O OD2 . ASP A 1 38 ? 33.086 -25.405 53.553 1.00 14.50 ? 22 ASP A OD2 1 ATOM 158 N N . VAL A 1 39 ? 28.294 -22.781 52.428 1.00 10.45 ? 23 VAL A N 1 ATOM 159 C CA . VAL A 1 39 ? 26.977 -23.164 51.924 1.00 9.05 ? 23 VAL A CA 1 ATOM 160 C C . VAL A 1 39 ? 26.966 -23.363 50.405 1.00 12.11 ? 23 VAL A C 1 ATOM 161 O O . VAL A 1 39 ? 27.745 -22.765 49.675 1.00 10.25 ? 23 VAL A O 1 ATOM 162 C CB . VAL A 1 39 ? 25.873 -22.167 52.337 1.00 9.92 ? 23 VAL A CB 1 ATOM 163 C CG1 . VAL A 1 39 ? 26.040 -21.758 53.799 1.00 9.43 ? 23 VAL A CG1 1 ATOM 164 C CG2 . VAL A 1 39 ? 25.869 -20.954 51.451 1.00 9.90 ? 23 VAL A CG2 1 ATOM 165 N N . VAL A 1 40 ? 26.094 -24.247 49.940 1.00 9.67 ? 24 VAL A N 1 ATOM 166 C CA . VAL A 1 40 ? 25.839 -24.379 48.520 1.00 10.82 ? 24 VAL A CA 1 ATOM 167 C C . VAL A 1 40 ? 24.420 -23.910 48.245 1.00 11.22 ? 24 VAL A C 1 ATOM 168 O O . VAL A 1 40 ? 23.461 -24.371 48.879 1.00 11.05 ? 24 VAL A O 1 ATOM 169 C CB . VAL A 1 40 ? 26.013 -25.830 48.034 1.00 12.98 ? 24 VAL A CB 1 ATOM 170 C CG1 . VAL A 1 40 ? 25.927 -25.891 46.510 1.00 11.65 ? 24 VAL A CG1 1 ATOM 171 C CG2 . VAL A 1 40 ? 27.319 -26.389 48.502 1.00 13.27 ? 24 VAL A CG2 1 ATOM 172 N N . LEU A 1 41 ? 24.292 -22.982 47.307 1.00 10.32 ? 25 LEU A N 1 ATOM 173 C CA . LEU A 1 41 ? 22.994 -22.465 46.908 1.00 12.27 ? 25 LEU A CA 1 ATOM 174 C C . LEU A 1 41 ? 22.587 -22.980 45.526 1.00 11.66 ? 25 LEU A C 1 ATOM 175 O O . LEU A 1 41 ? 23.354 -22.951 44.576 1.00 12.83 ? 25 LEU A O 1 ATOM 176 C CB . LEU A 1 41 ? 22.997 -20.942 46.915 1.00 11.83 ? 25 LEU A CB 1 ATOM 177 C CG . LEU A 1 41 ? 23.658 -20.311 48.122 1.00 9.58 ? 25 LEU A CG 1 ATOM 178 C CD1 . LEU A 1 41 ? 23.793 -18.857 47.864 1.00 10.76 ? 25 LEU A CD1 1 ATOM 179 C CD2 . LEU A 1 41 ? 22.858 -20.572 49.369 1.00 8.19 ? 25 LEU A CD2 1 ATOM 180 N N . GLU A 1 42 ? 21.371 -23.484 45.442 1.00 15.25 ? 26 GLU A N 1 ATOM 181 C CA . GLU A 1 42 ? 20.864 -24.054 44.214 1.00 15.74 ? 26 GLU A CA 1 ATOM 182 C C . GLU A 1 42 ? 19.497 -23.478 44.009 1.00 16.04 ? 26 GLU A C 1 ATOM 183 O O . GLU A 1 42 ? 18.841 -23.089 44.967 1.00 19.22 ? 26 GLU A O 1 ATOM 184 C CB . GLU A 1 42 ? 20.817 -25.569 44.332 1.00 20.63 ? 26 GLU A CB 1 ATOM 185 C CG . GLU A 1 42 ? 22.204 -26.174 44.546 1.00 24.79 ? 26 GLU A CG 1 ATOM 186 C CD . GLU A 1 42 ? 22.195 -27.427 45.397 1.00 26.90 ? 26 GLU A CD 1 ATOM 187 O OE1 . GLU A 1 42 ? 21.345 -27.536 46.300 1.00 37.52 ? 26 GLU A OE1 1 ATOM 188 O OE2 . GLU A 1 42 ? 23.040 -28.309 45.163 1.00 26.17 ? 26 GLU A OE2 1 ATOM 189 N N . HIS A 1 43 ? 19.085 -23.361 42.760 1.00 16.05 ? 27 HIS A N 1 ATOM 190 C CA . HIS A 1 43 ? 17.765 -22.854 42.481 1.00 18.49 ? 27 HIS A CA 1 ATOM 191 C C . HIS A 1 43 ? 16.759 -23.763 43.179 1.00 18.48 ? 27 HIS A C 1 ATOM 192 O O . HIS A 1 43 ? 16.828 -24.996 43.100 1.00 20.70 ? 27 HIS A O 1 ATOM 193 C CB . HIS A 1 43 ? 17.510 -22.781 40.972 1.00 21.19 ? 27 HIS A CB 1 ATOM 194 C CG . HIS A 1 43 ? 16.149 -22.260 40.608 1.00 23.99 ? 27 HIS A CG 1 ATOM 195 N ND1 . HIS A 1 43 ? 15.789 -20.939 40.773 1.00 28.57 ? 27 HIS A ND1 1 ATOM 196 C CD2 . HIS A 1 43 ? 15.067 -22.882 40.090 1.00 25.77 ? 27 HIS A CD2 1 ATOM 197 C CE1 . HIS A 1 43 ? 14.541 -20.771 40.373 1.00 24.86 ? 27 HIS A CE1 1 ATOM 198 N NE2 . HIS A 1 43 ? 14.079 -21.937 39.950 1.00 24.75 ? 27 HIS A NE2 1 ATOM 199 N N . GLY A 1 44 ? 15.839 -23.129 43.893 1.00 19.28 ? 28 GLY A N 1 ATOM 200 C CA . GLY A 1 44 ? 14.858 -23.824 44.703 1.00 26.23 ? 28 GLY A CA 1 ATOM 201 C C . GLY A 1 44 ? 15.283 -23.847 46.155 1.00 20.75 ? 28 GLY A C 1 ATOM 202 O O . GLY A 1 44 ? 14.719 -23.167 47.008 1.00 30.18 ? 28 GLY A O 1 ATOM 203 N N . SER A 1 45 ? 16.301 -24.635 46.441 1.00 24.53 ? 29 SER A N 1 ATOM 204 C CA . SER A 1 45 ? 16.735 -24.818 47.808 1.00 22.77 ? 29 SER A CA 1 ATOM 205 C C . SER A 1 45 ? 16.956 -23.473 48.501 1.00 25.43 ? 29 SER A C 1 ATOM 206 O O . SER A 1 45 ? 17.051 -22.409 47.876 1.00 21.00 ? 29 SER A O 1 ATOM 207 C CB . SER A 1 45 ? 18.000 -25.703 47.873 1.00 24.69 ? 29 SER A CB 1 ATOM 208 O OG . SER A 1 45 ? 19.235 -24.972 47.843 1.00 29.28 ? 29 SER A OG 1 ATOM 209 N N . CYS A 1 46 ? 17.029 -23.526 49.814 1.00 19.32 ? 30 CYS A N 1 ATOM 210 C CA . CYS A 1 46 ? 17.422 -22.368 50.563 1.00 16.55 ? 30 CYS A CA 1 ATOM 211 C C . CYS A 1 46 ? 18.049 -22.953 51.803 1.00 15.04 ? 30 CYS A C 1 ATOM 212 O O . CYS A 1 46 ? 17.763 -24.091 52.155 1.00 15.43 ? 30 CYS A O 1 ATOM 213 C CB . CYS A 1 46 ? 16.230 -21.444 50.793 1.00 16.70 ? 30 CYS A CB 1 ATOM 214 S SG . CYS A 1 46 ? 15.186 -21.788 52.192 1.00 30.56 ? 30 CYS A SG 1 ATOM 215 N N . VAL A 1 47 ? 18.989 -22.230 52.395 1.00 14.26 ? 31 VAL A N 1 ATOM 216 C CA A VAL A 1 47 ? 19.757 -22.736 53.526 0.47 13.85 ? 31 VAL A CA 1 ATOM 217 C CA B VAL A 1 47 ? 19.726 -22.753 53.539 0.53 14.00 ? 31 VAL A CA 1 ATOM 218 C C . VAL A 1 47 ? 19.518 -21.865 54.764 1.00 12.36 ? 31 VAL A C 1 ATOM 219 O O . VAL A 1 47 ? 19.248 -20.679 54.652 1.00 12.07 ? 31 VAL A O 1 ATOM 220 C CB A VAL A 1 47 ? 21.264 -22.765 53.195 0.47 12.67 ? 31 VAL A CB 1 ATOM 221 C CB B VAL A 1 47 ? 21.232 -22.912 53.227 0.53 12.68 ? 31 VAL A CB 1 ATOM 222 C CG1 A VAL A 1 47 ? 22.012 -23.622 54.199 0.47 14.90 ? 31 VAL A CG1 1 ATOM 223 C CG1 B VAL A 1 47 ? 21.456 -24.061 52.265 0.53 13.13 ? 31 VAL A CG1 1 ATOM 224 C CG2 A VAL A 1 47 ? 21.494 -23.290 51.790 0.47 13.04 ? 31 VAL A CG2 1 ATOM 225 C CG2 B VAL A 1 47 ? 21.798 -21.640 52.654 0.53 11.20 ? 31 VAL A CG2 1 ATOM 226 N N . THR A 1 48 ? 19.608 -22.451 55.945 1.00 11.25 ? 32 THR A N 1 ATOM 227 C CA . THR A 1 48 ? 19.374 -21.676 57.146 1.00 15.67 ? 32 THR A CA 1 ATOM 228 C C . THR A 1 48 ? 20.334 -22.017 58.279 1.00 12.75 ? 32 THR A C 1 ATOM 229 O O . THR A 1 48 ? 20.842 -23.120 58.372 1.00 12.92 ? 32 THR A O 1 ATOM 230 C CB . THR A 1 48 ? 17.892 -21.805 57.627 1.00 15.57 ? 32 THR A CB 1 ATOM 231 O OG1 . THR A 1 48 ? 17.679 -20.929 58.730 1.00 12.99 ? 32 THR A OG1 1 ATOM 232 C CG2 . THR A 1 48 ? 17.533 -23.232 58.035 1.00 13.32 ? 32 THR A CG2 1 ATOM 233 N N . THR A 1 49 ? 20.590 -21.049 59.142 1.00 16.02 ? 33 THR A N 1 ATOM 234 C CA . THR A 1 49 ? 21.295 -21.335 60.387 1.00 16.78 ? 33 THR A CA 1 ATOM 235 C C . THR A 1 49 ? 20.904 -20.318 61.431 1.00 15.81 ? 33 THR A C 1 ATOM 236 O O . THR A 1 49 ? 20.138 -19.410 61.159 1.00 15.22 ? 33 THR A O 1 ATOM 237 C CB . THR A 1 49 ? 22.853 -21.397 60.243 1.00 18.03 ? 33 THR A CB 1 ATOM 238 O OG1 . THR A 1 49 ? 23.430 -21.887 61.467 1.00 17.72 ? 33 THR A OG1 1 ATOM 239 C CG2 . THR A 1 49 ? 23.461 -20.033 59.902 1.00 13.48 ? 33 THR A CG2 1 ATOM 240 N N . MET A 1 50 ? 21.445 -20.489 62.626 1.00 16.92 ? 34 MET A N 1 ATOM 241 C CA . MET A 1 50 ? 21.046 -19.712 63.781 1.00 18.80 ? 34 MET A CA 1 ATOM 242 C C . MET A 1 50 ? 22.192 -19.692 64.795 1.00 19.83 ? 34 MET A C 1 ATOM 243 O O . MET A 1 50 ? 22.840 -20.717 65.054 1.00 15.59 ? 34 MET A O 1 ATOM 244 C CB . MET A 1 50 ? 19.802 -20.347 64.391 1.00 21.19 ? 34 MET A CB 1 ATOM 245 C CG . MET A 1 50 ? 19.132 -19.548 65.464 1.00 25.74 ? 34 MET A CG 1 ATOM 246 S SD . MET A 1 50 ? 18.054 -20.620 66.422 1.00 37.58 ? 34 MET A SD 1 ATOM 247 C CE . MET A 1 50 ? 16.934 -19.440 67.187 1.00 35.59 ? 34 MET A CE 1 ATOM 248 N N . ALA A 1 51 ? 22.442 -18.501 65.332 1.00 23.25 ? 35 ALA A N 1 ATOM 249 C CA . ALA A 1 51 ? 23.494 -18.258 66.309 1.00 21.13 ? 35 ALA A CA 1 ATOM 250 C C . ALA A 1 51 ? 22.962 -18.285 67.734 1.00 31.55 ? 35 ALA A C 1 ATOM 251 O O . ALA A 1 51 ? 21.748 -18.278 67.953 1.00 30.45 ? 35 ALA A O 1 ATOM 252 C CB . ALA A 1 51 ? 24.132 -16.920 66.039 1.00 19.60 ? 35 ALA A CB 1 ATOM 253 N N . LYS A 1 52 ? 23.888 -18.284 68.698 1.00 37.50 ? 36 LYS A N 1 ATOM 254 C CA . LYS A 1 52 ? 23.546 -18.324 70.127 1.00 37.33 ? 36 LYS A CA 1 ATOM 255 C C . LYS A 1 52 ? 22.552 -17.200 70.456 1.00 34.61 ? 36 LYS A C 1 ATOM 256 O O . LYS A 1 52 ? 22.943 -16.052 70.606 1.00 40.63 ? 36 LYS A O 1 ATOM 257 C CB . LYS A 1 52 ? 24.819 -18.273 71.052 1.00 36.06 ? 36 LYS A CB 1 ATOM 258 C CG . LYS A 1 52 ? 26.125 -17.566 70.478 1.00 40.85 ? 36 LYS A CG 1 ATOM 259 C CD . LYS A 1 52 ? 27.294 -17.204 71.515 1.00 33.46 ? 36 LYS A CD 1 ATOM 260 C CE . LYS A 1 52 ? 28.303 -18.351 71.963 1.00 28.13 ? 36 LYS A CE 1 ATOM 261 N NZ . LYS A 1 52 ? 29.786 -18.135 71.736 1.00 0.00 ? 36 LYS A NZ 1 ATOM 262 N N . ASP A 1 53 ? 21.267 -17.536 70.538 1.00 30.22 ? 37 ASP A N 1 ATOM 263 C CA . ASP A 1 53 ? 20.226 -16.558 70.877 1.00 29.26 ? 37 ASP A CA 1 ATOM 264 C C . ASP A 1 53 ? 20.178 -15.336 69.928 1.00 34.79 ? 37 ASP A C 1 ATOM 265 O O . ASP A 1 53 ? 20.361 -14.187 70.344 1.00 34.66 ? 37 ASP A O 1 ATOM 266 C CB . ASP A 1 53 ? 20.364 -16.128 72.343 1.00 38.74 ? 37 ASP A CB 1 ATOM 267 C CG . ASP A 1 53 ? 19.537 -16.995 73.292 1.00 43.09 ? 37 ASP A CG 1 ATOM 268 O OD1 . ASP A 1 53 ? 19.265 -18.179 72.970 1.00 38.20 ? 37 ASP A OD1 1 ATOM 269 O OD2 . ASP A 1 53 ? 19.150 -16.487 74.368 1.00 48.64 ? 37 ASP A OD2 1 ATOM 270 N N . LYS A 1 54 ? 19.924 -15.612 68.646 1.00 32.56 ? 38 LYS A N 1 ATOM 271 C CA . LYS A 1 54 ? 19.723 -14.595 67.615 1.00 26.99 ? 38 LYS A CA 1 ATOM 272 C C . LYS A 1 54 ? 18.654 -15.101 66.651 1.00 19.45 ? 38 LYS A C 1 ATOM 273 O O . LYS A 1 54 ? 18.283 -16.264 66.711 1.00 20.47 ? 38 LYS A O 1 ATOM 274 C CB . LYS A 1 54 ? 21.024 -14.334 66.868 1.00 24.83 ? 38 LYS A CB 1 ATOM 275 C CG . LYS A 1 54 ? 22.086 -13.645 67.702 1.00 24.48 ? 38 LYS A CG 1 ATOM 276 C CD . LYS A 1 54 ? 23.362 -13.454 66.912 1.00 24.68 ? 38 LYS A CD 1 ATOM 277 C CE . LYS A 1 54 ? 24.449 -12.810 67.742 1.00 33.01 ? 38 LYS A CE 1 ATOM 278 N NZ . LYS A 1 54 ? 24.369 -11.326 67.732 1.00 33.42 ? 38 LYS A NZ 1 ATOM 279 N N . PRO A 1 55 ? 18.142 -14.231 65.765 1.00 27.44 ? 39 PRO A N 1 ATOM 280 C CA . PRO A 1 55 ? 17.083 -14.676 64.844 1.00 25.22 ? 39 PRO A CA 1 ATOM 281 C C . PRO A 1 55 ? 17.624 -15.630 63.778 1.00 23.90 ? 39 PRO A C 1 ATOM 282 O O . PRO A 1 55 ? 18.823 -15.647 63.495 1.00 24.71 ? 39 PRO A O 1 ATOM 283 C CB . PRO A 1 55 ? 16.597 -13.375 64.188 1.00 22.34 ? 39 PRO A CB 1 ATOM 284 C CG . PRO A 1 55 ? 17.317 -12.248 64.883 1.00 24.26 ? 39 PRO A CG 1 ATOM 285 C CD . PRO A 1 55 ? 18.529 -12.832 65.523 1.00 24.68 ? 39 PRO A CD 1 ATOM 286 N N . THR A 1 56 ? 16.742 -16.418 63.180 1.00 21.41 ? 40 THR A N 1 ATOM 287 C CA . THR A 1 56 ? 17.162 -17.342 62.138 1.00 19.13 ? 40 THR A CA 1 ATOM 288 C C . THR A 1 56 ? 17.713 -16.568 60.943 1.00 18.40 ? 40 THR A C 1 ATOM 289 O O . THR A 1 56 ? 17.332 -15.436 60.689 1.00 20.09 ? 40 THR A O 1 ATOM 290 C CB . THR A 1 56 ? 15.999 -18.264 61.720 1.00 18.96 ? 40 THR A CB 1 ATOM 291 O OG1 . THR A 1 56 ? 15.800 -19.246 62.740 1.00 24.34 ? 40 THR A OG1 1 ATOM 292 C CG2 . THR A 1 56 ? 16.291 -18.970 60.440 1.00 18.11 ? 40 THR A CG2 1 ATOM 293 N N . LEU A 1 57 ? 18.636 -17.190 60.232 1.00 15.61 ? 41 LEU A N 1 ATOM 294 C CA . LEU A 1 57 ? 19.253 -16.593 59.069 1.00 18.90 ? 41 LEU A CA 1 ATOM 295 C C . LEU A 1 57 ? 19.082 -17.539 57.879 1.00 16.54 ? 41 LEU A C 1 ATOM 296 O O . LEU A 1 57 ? 19.456 -18.711 57.966 1.00 17.44 ? 41 LEU A O 1 ATOM 297 C CB . LEU A 1 57 ? 20.735 -16.360 59.352 1.00 16.27 ? 41 LEU A CB 1 ATOM 298 C CG . LEU A 1 57 ? 21.537 -15.629 58.284 1.00 17.45 ? 41 LEU A CG 1 ATOM 299 C CD1 . LEU A 1 57 ? 21.000 -14.236 58.064 1.00 15.89 ? 41 LEU A CD1 1 ATOM 300 C CD2 . LEU A 1 57 ? 22.988 -15.589 58.737 1.00 21.78 ? 41 LEU A CD2 1 ATOM 301 N N . ASP A 1 58 ? 18.489 -17.027 56.796 1.00 16.06 ? 42 ASP A N 1 ATOM 302 C CA . ASP A 1 58 ? 18.239 -17.791 55.576 1.00 14.43 ? 42 ASP A CA 1 ATOM 303 C C . ASP A 1 58 ? 19.004 -17.148 54.441 1.00 12.09 ? 42 ASP A C 1 ATOM 304 O O . ASP A 1 58 ? 19.121 -15.939 54.383 1.00 13.16 ? 42 ASP A O 1 ATOM 305 C CB . ASP A 1 58 ? 16.751 -17.775 55.178 1.00 15.97 ? 42 ASP A CB 1 ATOM 306 C CG . ASP A 1 58 ? 15.835 -18.467 56.181 1.00 17.91 ? 42 ASP A CG 1 ATOM 307 O OD1 . ASP A 1 58 ? 16.293 -19.140 57.131 1.00 16.18 ? 42 ASP A OD1 1 ATOM 308 O OD2 . ASP A 1 58 ? 14.617 -18.342 55.991 1.00 19.95 ? 42 ASP A OD2 1 ATOM 309 N N . ILE A 1 59 ? 19.498 -17.965 53.526 1.00 10.46 ? 43 ILE A N 1 ATOM 310 C CA . ILE A 1 59 ? 20.129 -17.488 52.310 1.00 11.32 ? 43 ILE A CA 1 ATOM 311 C C . ILE A 1 59 ? 19.548 -18.275 51.182 1.00 11.86 ? 43 ILE A C 1 ATOM 312 O O . ILE A 1 59 ? 19.239 -19.449 51.342 1.00 11.36 ? 43 ILE A O 1 ATOM 313 C CB . ILE A 1 59 ? 21.623 -17.757 52.290 1.00 12.23 ? 43 ILE A CB 1 ATOM 314 C CG1 . ILE A 1 59 ? 22.245 -17.304 53.602 1.00 18.18 ? 43 ILE A CG1 1 ATOM 315 C CG2 . ILE A 1 59 ? 22.278 -17.067 51.104 1.00 10.39 ? 43 ILE A CG2 1 ATOM 316 C CD1 . ILE A 1 59 ? 22.133 -15.840 53.835 1.00 23.15 ? 43 ILE A CD1 1 ATOM 317 N N . GLU A 1 60 ? 19.402 -17.630 50.032 1.00 13.49 ? 44 GLU A N 1 ATOM 318 C CA . GLU A 1 60 ? 18.796 -18.262 48.885 1.00 10.99 ? 44 GLU A CA 1 ATOM 319 C C . GLU A 1 60 ? 19.188 -17.562 47.601 1.00 11.87 ? 44 GLU A C 1 ATOM 320 O O . GLU A 1 60 ? 19.229 -16.338 47.539 1.00 13.36 ? 44 GLU A O 1 ATOM 321 C CB . GLU A 1 60 ? 17.283 -18.234 49.043 1.00 15.19 ? 44 GLU A CB 1 ATOM 322 C CG . GLU A 1 60 ? 16.518 -18.799 47.897 1.00 15.39 ? 44 GLU A CG 1 ATOM 323 C CD . GLU A 1 60 ? 15.039 -18.630 48.090 1.00 25.55 ? 44 GLU A CD 1 ATOM 324 O OE1 . GLU A 1 60 ? 14.637 -18.126 49.154 1.00 26.29 ? 44 GLU A OE1 1 ATOM 325 O OE2 . GLU A 1 60 ? 14.272 -19.005 47.191 1.00 29.37 ? 44 GLU A OE2 1 ATOM 326 N N . LEU A 1 61 ? 19.500 -18.365 46.592 1.00 13.33 ? 45 LEU A N 1 ATOM 327 C CA . LEU A 1 61 ? 19.764 -17.878 45.233 1.00 14.41 ? 45 LEU A CA 1 ATOM 328 C C . LEU A 1 61 ? 18.451 -17.665 44.507 1.00 11.14 ? 45 LEU A C 1 ATOM 329 O O . LEU A 1 61 ? 17.678 -18.598 44.333 1.00 12.95 ? 45 LEU A O 1 ATOM 330 C CB . LEU A 1 61 ? 20.634 -18.877 44.459 1.00 13.58 ? 45 LEU A CB 1 ATOM 331 C CG . LEU A 1 61 ? 20.873 -18.659 42.961 1.00 9.01 ? 45 LEU A CG 1 ATOM 332 C CD1 . LEU A 1 61 ? 21.529 -17.315 42.675 1.00 7.27 ? 45 LEU A CD1 1 ATOM 333 C CD2 . LEU A 1 61 ? 21.716 -19.795 42.458 1.00 10.40 ? 45 LEU A CD2 1 ATOM 334 N N . LEU A 1 62 ? 18.202 -16.429 44.096 1.00 13.81 ? 46 LEU A N 1 ATOM 335 C CA . LEU A 1 62 ? 16.948 -16.073 43.443 1.00 13.66 ? 46 LEU A CA 1 ATOM 336 C C . LEU A 1 62 ? 16.977 -16.224 41.920 1.00 15.29 ? 46 LEU A C 1 ATOM 337 O O . LEU A 1 62 ? 16.035 -16.759 41.322 1.00 17.66 ? 46 LEU A O 1 ATOM 338 C CB . LEU A 1 62 ? 16.562 -14.647 43.788 1.00 11.68 ? 46 LEU A CB 1 ATOM 339 C CG . LEU A 1 62 ? 16.161 -14.364 45.228 1.00 11.56 ? 46 LEU A CG 1 ATOM 340 C CD1 . LEU A 1 62 ? 15.767 -12.904 45.336 1.00 16.50 ? 46 LEU A CD1 1 ATOM 341 C CD2 . LEU A 1 62 ? 15.029 -15.253 45.666 1.00 16.80 ? 46 LEU A CD2 1 ATOM 342 N N . LYS A 1 63 ? 18.031 -15.731 41.282 1.00 14.14 ? 47 LYS A N 1 ATOM 343 C CA . LYS A 1 63 ? 18.185 -15.965 39.856 1.00 14.91 ? 47 LYS A CA 1 ATOM 344 C C . LYS A 1 63 ? 19.604 -15.854 39.343 1.00 10.51 ? 47 LYS A C 1 ATOM 345 O O . LYS A 1 63 ? 20.500 -15.385 40.019 1.00 10.92 ? 47 LYS A O 1 ATOM 346 C CB . LYS A 1 63 ? 17.257 -15.069 39.028 1.00 20.99 ? 47 LYS A CB 1 ATOM 347 C CG . LYS A 1 63 ? 17.703 -13.651 38.850 1.00 17.63 ? 47 LYS A CG 1 ATOM 348 C CD . LYS A 1 63 ? 17.021 -13.039 37.642 1.00 25.22 ? 47 LYS A CD 1 ATOM 349 C CE . LYS A 1 63 ? 15.522 -13.254 37.665 1.00 31.88 ? 47 LYS A CE 1 ATOM 350 N NZ . LYS A 1 63 ? 14.828 -12.488 36.586 1.00 36.13 ? 47 LYS A NZ 1 ATOM 351 N N . THR A 1 64 ? 19.767 -16.315 38.117 1.00 14.28 ? 48 THR A N 1 ATOM 352 C CA . THR A 1 64 ? 21.051 -16.407 37.461 1.00 12.55 ? 48 THR A CA 1 ATOM 353 C C . THR A 1 64 ? 20.788 -15.948 36.038 1.00 8.77 ? 48 THR A C 1 ATOM 354 O O . THR A 1 64 ? 19.917 -16.472 35.373 1.00 12.23 ? 48 THR A O 1 ATOM 355 C CB . THR A 1 64 ? 21.558 -17.855 37.492 1.00 9.41 ? 48 THR A CB 1 ATOM 356 O OG1 . THR A 1 64 ? 21.670 -18.274 38.853 1.00 9.61 ? 48 THR A OG1 1 ATOM 357 C CG2 . THR A 1 64 ? 22.914 -18.010 36.794 1.00 8.96 ? 48 THR A CG2 1 ATOM 358 N N . GLU A 1 65 ? 21.514 -14.946 35.590 1.00 9.36 ? 49 GLU A N 1 ATOM 359 C CA . GLU A 1 65 ? 21.240 -14.331 34.308 1.00 10.09 ? 49 GLU A CA 1 ATOM 360 C C . GLU A 1 65 ? 22.499 -14.120 33.529 1.00 8.78 ? 49 GLU A C 1 ATOM 361 O O . GLU A 1 65 ? 23.513 -13.712 34.078 1.00 9.70 ? 49 GLU A O 1 ATOM 362 C CB . GLU A 1 65 ? 20.610 -12.958 34.478 1.00 12.71 ? 49 GLU A CB 1 ATOM 363 C CG . GLU A 1 65 ? 19.355 -12.924 35.273 1.00 15.68 ? 49 GLU A CG 1 ATOM 364 C CD . GLU A 1 65 ? 18.922 -11.501 35.576 1.00 21.18 ? 49 GLU A CD 1 ATOM 365 O OE1 . GLU A 1 65 ? 18.191 -10.899 34.754 1.00 25.87 ? 49 GLU A OE1 1 ATOM 366 O OE2 . GLU A 1 65 ? 19.330 -10.972 36.630 1.00 24.96 ? 49 GLU A OE2 1 ATOM 367 N N . VAL A 1 66 ? 22.397 -14.383 32.230 1.00 9.31 ? 50 VAL A N 1 ATOM 368 C CA . VAL A 1 66 ? 23.393 -13.988 31.258 1.00 11.48 ? 50 VAL A CA 1 ATOM 369 C C . VAL A 1 66 ? 22.834 -12.814 30.459 1.00 9.96 ? 50 VAL A C 1 ATOM 370 O O . VAL A 1 66 ? 21.713 -12.853 29.968 1.00 12.02 ? 50 VAL A O 1 ATOM 371 C CB . VAL A 1 66 ? 23.793 -15.171 30.332 1.00 10.09 ? 50 VAL A CB 1 ATOM 372 C CG1 . VAL A 1 66 ? 24.718 -14.708 29.237 1.00 6.68 ? 50 VAL A CG1 1 ATOM 373 C CG2 . VAL A 1 66 ? 24.436 -16.296 31.144 1.00 7.86 ? 50 VAL A CG2 1 ATOM 374 N N . THR A 1 67 ? 23.611 -11.749 30.379 1.00 10.38 ? 51 THR A N 1 ATOM 375 C CA . THR A 1 67 ? 23.125 -10.502 29.833 1.00 14.12 ? 51 THR A CA 1 ATOM 376 C C . THR A 1 67 ? 24.137 -10.002 28.819 1.00 10.22 ? 51 THR A C 1 ATOM 377 O O . THR A 1 67 ? 25.309 -9.947 29.122 1.00 9.89 ? 51 THR A O 1 ATOM 378 C CB . THR A 1 67 ? 22.868 -9.474 30.976 1.00 13.35 ? 51 THR A CB 1 ATOM 379 O OG1 . THR A 1 67 ? 22.785 -8.137 30.453 1.00 19.71 ? 51 THR A OG1 1 ATOM 380 C CG2 . THR A 1 67 ? 23.978 -9.518 31.998 1.00 21.53 ? 51 THR A CG2 1 ATOM 381 N N . ASN A 1 68 ? 23.681 -9.705 27.605 1.00 11.77 ? 52 ASN A N 1 ATOM 382 C CA . ASN A 1 68 ? 24.480 -9.039 26.580 1.00 11.83 ? 52 ASN A CA 1 ATOM 383 C C . ASN A 1 68 ? 25.746 -9.760 26.165 1.00 10.16 ? 52 ASN A C 1 ATOM 384 O O . ASN A 1 68 ? 26.795 -9.119 26.069 1.00 13.63 ? 52 ASN A O 1 ATOM 385 C CB . ASN A 1 68 ? 24.886 -7.636 27.054 1.00 16.49 ? 52 ASN A CB 1 ATOM 386 C CG . ASN A 1 68 ? 23.771 -6.631 26.928 1.00 14.31 ? 52 ASN A CG 1 ATOM 387 O OD1 . ASN A 1 68 ? 22.937 -6.738 26.060 1.00 21.08 ? 52 ASN A OD1 1 ATOM 388 N ND2 . ASN A 1 68 ? 23.756 -5.662 27.797 1.00 14.17 ? 52 ASN A ND2 1 ATOM 389 N N . PRO A 1 69 ? 25.679 -11.087 25.927 1.00 9.75 ? 53 PRO A N 1 ATOM 390 C CA . PRO A 1 69 ? 26.875 -11.808 25.451 1.00 8.90 ? 53 PRO A CA 1 ATOM 391 C C . PRO A 1 69 ? 27.344 -11.373 24.042 1.00 8.54 ? 53 PRO A C 1 ATOM 392 O O . PRO A 1 69 ? 26.506 -11.070 23.203 1.00 9.41 ? 53 PRO A O 1 ATOM 393 C CB . PRO A 1 69 ? 26.417 -13.269 25.450 1.00 8.04 ? 53 PRO A CB 1 ATOM 394 C CG . PRO A 1 69 ? 24.951 -13.207 25.416 1.00 9.27 ? 53 PRO A CG 1 ATOM 395 C CD . PRO A 1 69 ? 24.553 -11.999 26.159 1.00 7.24 ? 53 PRO A CD 1 ATOM 396 N N . ALA A 1 70 ? 28.657 -11.330 23.812 1.00 8.18 ? 54 ALA A N 1 ATOM 397 C CA . ALA A 1 70 ? 29.229 -10.965 22.517 1.00 9.56 ? 54 ALA A CA 1 ATOM 398 C C . ALA A 1 70 ? 28.958 -11.992 21.411 1.00 9.17 ? 54 ALA A C 1 ATOM 399 O O . ALA A 1 70 ? 29.006 -13.185 21.638 1.00 6.84 ? 54 ALA A O 1 ATOM 400 C CB . ALA A 1 70 ? 30.725 -10.789 22.651 1.00 9.02 ? 54 ALA A CB 1 ATOM 401 N N . VAL A 1 71 ? 28.705 -11.504 20.200 1.00 11.14 ? 55 VAL A N 1 ATOM 402 C CA . VAL A 1 71 ? 28.590 -12.366 19.020 1.00 9.56 ? 55 VAL A CA 1 ATOM 403 C C . VAL A 1 71 ? 29.957 -12.851 18.561 1.00 7.22 ? 55 VAL A C 1 ATOM 404 O O . VAL A 1 71 ? 30.854 -12.055 18.289 1.00 9.32 ? 55 VAL A O 1 ATOM 405 C CB . VAL A 1 71 ? 27.887 -11.641 17.840 1.00 9.22 ? 55 VAL A CB 1 ATOM 406 C CG1 . VAL A 1 71 ? 27.849 -12.529 16.597 1.00 7.27 ? 55 VAL A CG1 1 ATOM 407 C CG2 . VAL A 1 71 ? 26.494 -11.256 18.239 1.00 14.71 ? 55 VAL A CG2 1 ATOM 408 N N . LEU A 1 72 ? 30.092 -14.167 18.473 1.00 8.25 ? 56 LEU A N 1 ATOM 409 C CA . LEU A 1 72 ? 31.241 -14.824 17.860 1.00 10.07 ? 56 LEU A CA 1 ATOM 410 C C . LEU A 1 72 ? 31.229 -14.691 16.311 1.00 9.67 ? 56 LEU A C 1 ATOM 411 O O . LEU A 1 72 ? 32.133 -14.098 15.699 1.00 8.68 ? 56 LEU A O 1 ATOM 412 C CB . LEU A 1 72 ? 31.185 -16.294 18.272 1.00 11.19 ? 56 LEU A CB 1 ATOM 413 C CG . LEU A 1 72 ? 32.424 -17.168 18.170 1.00 16.35 ? 56 LEU A CG 1 ATOM 414 C CD1 . LEU A 1 72 ? 33.628 -16.423 18.731 1.00 13.53 ? 56 LEU A CD1 1 ATOM 415 C CD2 . LEU A 1 72 ? 32.176 -18.493 18.922 1.00 11.78 ? 56 LEU A CD2 1 ATOM 416 N N . ARG A 1 73 ? 30.185 -15.251 15.697 1.00 13.50 ? 57 ARG A N 1 ATOM 417 C CA . ARG A 1 73 ? 29.907 -15.093 14.275 1.00 11.54 ? 57 ARG A CA 1 ATOM 418 C C . ARG A 1 73 ? 28.409 -14.998 14.093 1.00 10.26 ? 57 ARG A C 1 ATOM 419 O O . ARG A 1 73 ? 27.658 -15.455 14.942 1.00 10.25 ? 57 ARG A O 1 ATOM 420 C CB . ARG A 1 73 ? 30.364 -16.306 13.466 1.00 11.62 ? 57 ARG A CB 1 ATOM 421 C CG . ARG A 1 73 ? 31.842 -16.563 13.405 1.00 13.24 ? 57 ARG A CG 1 ATOM 422 C CD . ARG A 1 73 ? 32.080 -17.829 12.623 1.00 9.89 ? 57 ARG A CD 1 ATOM 423 N NE . ARG A 1 73 ? 33.499 -18.135 12.498 1.00 11.23 ? 57 ARG A NE 1 ATOM 424 C CZ . ARG A 1 73 ? 33.975 -19.273 12.017 1.00 13.29 ? 57 ARG A CZ 1 ATOM 425 N NH1 . ARG A 1 73 ? 33.152 -20.227 11.615 1.00 13.13 ? 57 ARG A NH1 1 ATOM 426 N NH2 . ARG A 1 73 ? 35.278 -19.448 11.935 1.00 18.94 ? 57 ARG A NH2 1 ATOM 427 N N . LYS A 1 74 ? 27.980 -14.439 12.967 1.00 10.81 ? 58 LYS A N 1 ATOM 428 C CA . LYS A 1 74 ? 26.608 -14.605 12.513 1.00 10.44 ? 58 LYS A CA 1 ATOM 429 C C . LYS A 1 74 ? 26.663 -15.525 11.306 1.00 10.16 ? 58 LYS A C 1 ATOM 430 O O . LYS A 1 74 ? 27.638 -15.499 10.560 1.00 9.58 ? 58 LYS A O 1 ATOM 431 C CB . LYS A 1 74 ? 25.961 -13.264 12.139 1.00 11.11 ? 58 LYS A CB 1 ATOM 432 C CG . LYS A 1 74 ? 25.862 -12.259 13.257 1.00 13.56 ? 58 LYS A CG 1 ATOM 433 C CD . LYS A 1 74 ? 25.366 -10.912 12.745 1.00 23.75 ? 58 LYS A CD 1 ATOM 434 C CE . LYS A 1 74 ? 25.917 -9.751 13.569 1.00 31.44 ? 58 LYS A CE 1 ATOM 435 N NZ . LYS A 1 74 ? 25.838 -8.408 12.889 1.00 32.03 ? 58 LYS A NZ 1 ATOM 436 N N . LEU A 1 75 ? 25.629 -16.344 11.134 1.00 10.88 ? 59 LEU A N 1 ATOM 437 C CA . LEU A 1 75 ? 25.519 -17.256 9.997 1.00 10.56 ? 59 LEU A CA 1 ATOM 438 C C . LEU A 1 75 ? 24.231 -16.986 9.223 1.00 9.55 ? 59 LEU A C 1 ATOM 439 O O . LEU A 1 75 ? 23.217 -16.626 9.798 1.00 10.52 ? 59 LEU A O 1 ATOM 440 C CB . LEU A 1 75 ? 25.542 -18.723 10.447 1.00 7.99 ? 59 LEU A CB 1 ATOM 441 C CG . LEU A 1 75 ? 26.590 -19.170 11.468 1.00 10.25 ? 59 LEU A CG 1 ATOM 442 C CD1 . LEU A 1 75 ? 26.636 -20.678 11.492 1.00 9.22 ? 59 LEU A CD1 1 ATOM 443 C CD2 . LEU A 1 75 ? 27.943 -18.625 11.160 1.00 12.70 ? 59 LEU A CD2 1 ATOM 444 N N . CYS A 1 76 ? 24.282 -17.163 7.908 1.00 11.72 ? 60 CYS A N 1 ATOM 445 C CA . CYS A 1 76 ? 23.127 -16.897 7.065 1.00 13.38 ? 60 CYS A CA 1 ATOM 446 C C . CYS A 1 76 ? 22.389 -18.183 6.759 1.00 10.49 ? 60 CYS A C 1 ATOM 447 O O . CYS A 1 76 ? 22.983 -19.114 6.241 1.00 11.99 ? 60 CYS A O 1 ATOM 448 C CB . CYS A 1 76 ? 23.547 -16.213 5.758 1.00 12.02 ? 60 CYS A CB 1 ATOM 449 S SG . CYS A 1 76 ? 22.145 -15.484 4.894 1.00 14.03 ? 60 CYS A SG 1 ATOM 450 N N . ILE A 1 77 ? 21.096 -18.223 7.090 1.00 13.65 ? 61 ILE A N 1 ATOM 451 C CA . ILE A 1 77 ? 20.255 -19.407 6.837 1.00 13.65 ? 61 ILE A CA 1 ATOM 452 C C . ILE A 1 77 ? 19.252 -19.189 5.697 1.00 15.32 ? 61 ILE A C 1 ATOM 453 O O . ILE A 1 77 ? 18.697 -20.156 5.166 1.00 14.70 ? 61 ILE A O 1 ATOM 454 C CB . ILE A 1 77 ? 19.483 -19.894 8.108 1.00 15.28 ? 61 ILE A CB 1 ATOM 455 C CG1 . ILE A 1 77 ? 18.383 -18.903 8.482 1.00 15.18 ? 61 ILE A CG1 1 ATOM 456 C CG2 . ILE A 1 77 ? 20.438 -20.154 9.271 1.00 14.97 ? 61 ILE A CG2 1 ATOM 457 C CD1 . ILE A 1 77 ? 17.559 -19.327 9.668 1.00 19.03 ? 61 ILE A CD1 1 ATOM 458 N N . GLU A 1 78 ? 19.028 -17.929 5.327 1.00 14.91 ? 62 GLU A N 1 ATOM 459 C CA . GLU A 1 78 ? 18.213 -17.603 4.162 1.00 15.35 ? 62 GLU A CA 1 ATOM 460 C C . GLU A 1 78 ? 18.824 -16.421 3.442 1.00 11.35 ? 62 GLU A C 1 ATOM 461 O O . GLU A 1 78 ? 18.907 -15.352 4.011 1.00 12.06 ? 62 GLU A O 1 ATOM 462 C CB . GLU A 1 78 ? 16.794 -17.254 4.595 1.00 15.17 ? 62 GLU A CB 1 ATOM 463 C CG . GLU A 1 78 ? 15.805 -17.188 3.472 1.00 15.00 ? 62 GLU A CG 1 ATOM 464 C CD . GLU A 1 78 ? 14.396 -17.002 3.969 1.00 19.88 ? 62 GLU A CD 1 ATOM 465 O OE1 . GLU A 1 78 ? 14.230 -16.686 5.166 1.00 23.39 ? 62 GLU A OE1 1 ATOM 466 O OE2 . GLU A 1 78 ? 13.454 -17.179 3.173 1.00 30.71 ? 62 GLU A OE2 1 ATOM 467 N N . ALA A 1 79 ? 19.245 -16.603 2.195 1.00 15.55 ? 63 ALA A N 1 ATOM 468 C CA . ALA A 1 79 ? 19.840 -15.517 1.430 1.00 12.25 ? 63 ALA A CA 1 ATOM 469 C C . ALA A 1 79 ? 18.910 -15.089 0.326 1.00 10.99 ? 63 ALA A C 1 ATOM 470 O O . ALA A 1 79 ? 18.005 -15.812 -0.020 1.00 11.56 ? 63 ALA A O 1 ATOM 471 C CB . ALA A 1 79 ? 21.142 -15.944 0.843 1.00 12.60 ? 63 ALA A CB 1 ATOM 472 N N . LYS A 1 80 ? 19.141 -13.907 -0.228 1.00 14.85 ? 64 LYS A N 1 ATOM 473 C CA . LYS A 1 80 ? 18.481 -13.525 -1.469 1.00 16.57 ? 64 LYS A CA 1 ATOM 474 C C . LYS A 1 80 ? 19.486 -13.024 -2.483 1.00 11.80 ? 64 LYS A C 1 ATOM 475 O O . LYS A 1 80 ? 20.560 -12.580 -2.129 1.00 12.21 ? 64 LYS A O 1 ATOM 476 C CB . LYS A 1 80 ? 17.389 -12.479 -1.230 1.00 15.90 ? 64 LYS A CB 1 ATOM 477 C CG . LYS A 1 80 ? 17.854 -11.161 -0.657 1.00 19.64 ? 64 LYS A CG 1 ATOM 478 C CD . LYS A 1 80 ? 16.686 -10.190 -0.549 1.00 26.93 ? 64 LYS A CD 1 ATOM 479 C CE . LYS A 1 80 ? 17.132 -8.731 -0.444 1.00 38.21 ? 64 LYS A CE 1 ATOM 480 N NZ . LYS A 1 80 ? 17.675 -8.183 -1.734 1.00 39.77 ? 64 LYS A NZ 1 ATOM 481 N N . ILE A 1 81 ? 19.116 -13.127 -3.752 1.00 13.57 ? 65 ILE A N 1 ATOM 482 C CA . ILE A 1 81 ? 19.971 -12.742 -4.866 1.00 15.05 ? 65 ILE A CA 1 ATOM 483 C C . ILE A 1 81 ? 19.299 -11.649 -5.693 1.00 16.87 ? 65 ILE A C 1 ATOM 484 O O . ILE A 1 81 ? 18.097 -11.689 -5.930 1.00 18.42 ? 65 ILE A O 1 ATOM 485 C CB . ILE A 1 81 ? 20.245 -13.947 -5.777 1.00 13.94 ? 65 ILE A CB 1 ATOM 486 C CG1 . ILE A 1 81 ? 21.240 -14.904 -5.123 1.00 15.40 ? 65 ILE A CG1 1 ATOM 487 C CG2 . ILE A 1 81 ? 20.741 -13.496 -7.120 1.00 18.42 ? 65 ILE A CG2 1 ATOM 488 C CD1 . ILE A 1 81 ? 22.602 -14.333 -4.935 1.00 19.15 ? 65 ILE A CD1 1 ATOM 489 N N . SER A 1 82 ? 20.077 -10.660 -6.118 1.00 19.61 ? 66 SER A N 1 ATOM 490 C CA . SER A 1 82 ? 19.606 -9.688 -7.111 1.00 21.01 ? 66 SER A CA 1 ATOM 491 C C . SER A 1 82 ? 20.769 -9.011 -7.854 1.00 19.34 ? 66 SER A C 1 ATOM 492 O O . SER A 1 82 ? 21.937 -9.283 -7.589 1.00 19.24 ? 66 SER A O 1 ATOM 493 C CB . SER A 1 82 ? 18.670 -8.648 -6.478 1.00 17.67 ? 66 SER A CB 1 ATOM 494 O OG . SER A 1 82 ? 19.382 -7.674 -5.742 1.00 23.61 ? 66 SER A OG 1 ATOM 495 N N . ASN A 1 83 ? 20.423 -8.140 -8.794 1.00 22.50 ? 67 ASN A N 1 ATOM 496 C CA . ASN A 1 83 ? 21.395 -7.408 -9.589 1.00 17.14 ? 67 ASN A CA 1 ATOM 497 C C . ASN A 1 83 ? 22.324 -8.318 -10.384 1.00 12.77 ? 67 ASN A C 1 ATOM 498 O O . ASN A 1 83 ? 23.466 -7.982 -10.636 1.00 21.64 ? 67 ASN A O 1 ATOM 499 C CB . ASN A 1 83 ? 22.183 -6.461 -8.692 1.00 18.79 ? 67 ASN A CB 1 ATOM 500 C CG . ASN A 1 83 ? 21.316 -5.361 -8.114 1.00 26.37 ? 67 ASN A CG 1 ATOM 501 O OD1 . ASN A 1 83 ? 20.506 -5.611 -7.227 1.00 26.30 ? 67 ASN A OD1 1 ATOM 502 N ND2 . ASN A 1 83 ? 21.481 -4.135 -8.611 1.00 34.16 ? 67 ASN A ND2 1 ATOM 503 N N . THR A 1 84 ? 21.823 -9.462 -10.811 1.00 13.76 ? 68 THR A N 1 ATOM 504 C CA . THR A 1 84 ? 22.596 -10.355 -11.651 1.00 14.62 ? 68 THR A CA 1 ATOM 505 C C . THR A 1 84 ? 23.059 -9.666 -12.941 1.00 14.73 ? 68 THR A C 1 ATOM 506 O O . THR A 1 84 ? 22.249 -9.185 -13.723 1.00 11.10 ? 68 THR A O 1 ATOM 507 C CB . THR A 1 84 ? 21.799 -11.604 -12.010 1.00 11.09 ? 68 THR A CB 1 ATOM 508 O OG1 . THR A 1 84 ? 21.416 -12.284 -10.816 1.00 14.35 ? 68 THR A OG1 1 ATOM 509 C CG2 . THR A 1 84 ? 22.637 -12.522 -12.845 1.00 13.95 ? 68 THR A CG2 1 ATOM 510 N N . THR A 1 85 ? 24.371 -9.615 -13.146 1.00 12.43 ? 69 THR A N 1 ATOM 511 C CA . THR A 1 85 ? 24.947 -8.954 -14.297 1.00 11.77 ? 69 THR A CA 1 ATOM 512 C C . THR A 1 85 ? 25.871 -9.953 -14.918 1.00 11.16 ? 69 THR A C 1 ATOM 513 O O . THR A 1 85 ? 26.484 -10.735 -14.215 1.00 10.50 ? 69 THR A O 1 ATOM 514 C CB . THR A 1 85 ? 25.784 -7.733 -13.923 1.00 11.14 ? 69 THR A CB 1 ATOM 515 O OG1 . THR A 1 85 ? 25.208 -7.070 -12.801 1.00 17.30 ? 69 THR A OG1 1 ATOM 516 C CG2 . THR A 1 85 ? 25.871 -6.787 -15.077 1.00 12.73 ? 69 THR A CG2 1 ATOM 517 N N . THR A 1 86 ? 25.958 -9.934 -16.237 1.00 9.41 ? 70 THR A N 1 ATOM 518 C CA . THR A 1 86 ? 26.817 -10.845 -16.967 1.00 10.47 ? 70 THR A CA 1 ATOM 519 C C . THR A 1 86 ? 27.540 -10.081 -18.038 1.00 9.57 ? 70 THR A C 1 ATOM 520 O O . THR A 1 86 ? 26.952 -9.277 -18.746 1.00 10.66 ? 70 THR A O 1 ATOM 521 C CB . THR A 1 86 ? 26.028 -11.973 -17.683 1.00 9.95 ? 70 THR A CB 1 ATOM 522 O OG1 . THR A 1 86 ? 25.366 -12.809 -16.735 1.00 9.15 ? 70 THR A OG1 1 ATOM 523 C CG2 . THR A 1 86 ? 26.959 -12.831 -18.504 1.00 9.91 ? 70 THR A CG2 1 ATOM 524 N N . ASP A 1 87 ? 28.825 -10.343 -18.156 1.00 9.83 ? 71 ASP A N 1 ATOM 525 C CA . ASP A 1 87 ? 29.570 -9.895 -19.315 1.00 13.80 ? 71 ASP A CA 1 ATOM 526 C C . ASP A 1 87 ? 30.157 -11.119 -20.042 1.00 11.12 ? 71 ASP A C 1 ATOM 527 O O . ASP A 1 87 ? 30.628 -12.060 -19.423 1.00 9.52 ? 71 ASP A O 1 ATOM 528 C CB . ASP A 1 87 ? 30.648 -8.884 -18.908 1.00 12.04 ? 71 ASP A CB 1 ATOM 529 C CG . ASP A 1 87 ? 31.273 -8.195 -20.097 1.00 16.68 ? 71 ASP A CG 1 ATOM 530 O OD1 . ASP A 1 87 ? 30.543 -7.725 -20.996 1.00 14.95 ? 71 ASP A OD1 1 ATOM 531 O OD2 . ASP A 1 87 ? 32.514 -8.141 -20.130 1.00 20.32 ? 71 ASP A OD2 1 ATOM 532 N N . SER A 1 88 ? 30.089 -11.102 -21.367 1.00 10.16 ? 72 SER A N 1 ATOM 533 C CA . SER A 1 88 ? 30.559 -12.204 -22.183 1.00 12.41 ? 72 SER A CA 1 ATOM 534 C C . SER A 1 88 ? 31.330 -11.590 -23.317 1.00 13.59 ? 72 SER A C 1 ATOM 535 O O . SER A 1 88 ? 31.067 -10.448 -23.688 1.00 17.86 ? 72 SER A O 1 ATOM 536 C CB . SER A 1 88 ? 29.386 -12.964 -22.759 1.00 10.82 ? 72 SER A CB 1 ATOM 537 O OG . SER A 1 88 ? 28.580 -12.057 -23.482 1.00 15.41 ? 72 SER A OG 1 ATOM 538 N N . ARG A 1 89 ? 32.296 -12.325 -23.856 1.00 11.22 ? 73 ARG A N 1 ATOM 539 C CA A ARG A 1 89 ? 33.073 -11.815 -24.967 0.57 12.60 ? 73 ARG A CA 1 ATOM 540 C CA B ARG A 1 89 ? 33.157 -11.835 -24.924 0.43 12.59 ? 73 ARG A CA 1 ATOM 541 C C . ARG A 1 89 ? 33.286 -12.902 -26.000 1.00 10.43 ? 73 ARG A C 1 ATOM 542 O O . ARG A 1 89 ? 33.383 -14.062 -25.676 1.00 9.38 ? 73 ARG A O 1 ATOM 543 C CB A ARG A 1 89 ? 34.410 -11.233 -24.488 0.57 12.17 ? 73 ARG A CB 1 ATOM 544 C CB B ARG A 1 89 ? 34.557 -11.534 -24.380 0.43 12.14 ? 73 ARG A CB 1 ATOM 545 C CG A ARG A 1 89 ? 34.306 -9.818 -23.924 0.57 12.47 ? 73 ARG A CG 1 ATOM 546 C CG B ARG A 1 89 ? 34.599 -10.579 -23.211 0.43 12.11 ? 73 ARG A CG 1 ATOM 547 C CD A ARG A 1 89 ? 33.655 -8.857 -24.934 0.57 16.63 ? 73 ARG A CD 1 ATOM 548 C CD B ARG A 1 89 ? 34.522 -9.149 -23.686 0.43 13.81 ? 73 ARG A CD 1 ATOM 549 N NE A ARG A 1 89 ? 33.746 -7.446 -24.542 0.57 19.15 ? 73 ARG A NE 1 ATOM 550 N NE B ARG A 1 89 ? 34.741 -8.177 -22.615 0.43 15.16 ? 73 ARG A NE 1 ATOM 551 C CZ A ARG A 1 89 ? 32.817 -6.779 -23.855 0.57 19.00 ? 73 ARG A CZ 1 ATOM 552 C CZ B ARG A 1 89 ? 35.924 -7.668 -22.276 0.43 15.52 ? 73 ARG A CZ 1 ATOM 553 N NH1 A ARG A 1 89 ? 31.693 -7.366 -23.457 0.57 14.95 ? 73 ARG A NH1 1 ATOM 554 N NH1 B ARG A 1 89 ? 37.033 -8.035 -22.907 0.43 14.77 ? 73 ARG A NH1 1 ATOM 555 N NH2 A ARG A 1 89 ? 33.019 -5.503 -23.564 0.57 23.88 ? 73 ARG A NH2 1 ATOM 556 N NH2 B ARG A 1 89 ? 36.000 -6.785 -21.293 0.43 16.39 ? 73 ARG A NH2 1 ATOM 557 N N . CYS A 1 90 ? 33.316 -12.499 -27.262 1.00 11.64 ? 74 CYS A N 1 ATOM 558 C CA . CYS A 1 90 ? 33.551 -13.422 -28.361 1.00 11.17 ? 74 CYS A CA 1 ATOM 559 C C . CYS A 1 90 ? 34.943 -14.023 -28.232 1.00 12.91 ? 74 CYS A C 1 ATOM 560 O O . CYS A 1 90 ? 35.824 -13.422 -27.642 1.00 12.61 ? 74 CYS A O 1 ATOM 561 C CB . CYS A 1 90 ? 33.428 -12.716 -29.704 1.00 10.55 ? 74 CYS A CB 1 ATOM 562 S SG . CYS A 1 90 ? 31.758 -12.442 -30.240 1.00 12.35 ? 74 CYS A SG 1 ATOM 563 N N . PRO A 1 91 ? 35.144 -15.213 -28.801 1.00 11.52 ? 75 PRO A N 1 ATOM 564 C CA . PRO A 1 91 ? 36.395 -15.942 -28.617 1.00 14.05 ? 75 PRO A CA 1 ATOM 565 C C . PRO A 1 91 ? 37.663 -15.108 -28.819 1.00 13.87 ? 75 PRO A C 1 ATOM 566 O O . PRO A 1 91 ? 38.663 -15.407 -28.181 1.00 12.84 ? 75 PRO A O 1 ATOM 567 C CB . PRO A 1 91 ? 36.291 -17.047 -29.666 1.00 11.87 ? 75 PRO A CB 1 ATOM 568 C CG . PRO A 1 91 ? 34.859 -17.348 -29.711 1.00 9.99 ? 75 PRO A CG 1 ATOM 569 C CD . PRO A 1 91 ? 34.135 -16.049 -29.474 1.00 9.43 ? 75 PRO A CD 1 ATOM 570 N N . THR A 1 92 ? 37.626 -14.099 -29.688 1.00 18.92 ? 76 THR A N 1 ATOM 571 C CA . THR A 1 92 ? 38.835 -13.337 -30.040 1.00 16.82 ? 76 THR A CA 1 ATOM 572 C C . THR A 1 92 ? 38.883 -11.995 -29.321 1.00 17.03 ? 76 THR A C 1 ATOM 573 O O . THR A 1 92 ? 39.638 -11.103 -29.713 1.00 18.78 ? 76 THR A O 1 ATOM 574 C CB . THR A 1 92 ? 38.950 -13.083 -31.573 1.00 15.17 ? 76 THR A CB 1 ATOM 575 O OG1 . THR A 1 92 ? 37.769 -12.444 -32.064 1.00 20.91 ? 76 THR A OG1 1 ATOM 576 C CG2 . THR A 1 92 ? 39.156 -14.392 -32.329 1.00 17.66 ? 76 THR A CG2 1 ATOM 577 N N . GLN A 1 93 ? 38.089 -11.871 -28.263 1.00 15.22 ? 77 GLN A N 1 ATOM 578 C CA . GLN A 1 93 ? 37.845 -10.594 -27.621 1.00 15.59 ? 77 GLN A CA 1 ATOM 579 C C . GLN A 1 93 ? 38.173 -10.590 -26.135 1.00 13.39 ? 77 GLN A C 1 ATOM 580 O O . GLN A 1 93 ? 37.648 -9.765 -25.394 1.00 14.53 ? 77 GLN A O 1 ATOM 581 C CB . GLN A 1 93 ? 36.389 -10.191 -27.813 1.00 16.72 ? 77 GLN A CB 1 ATOM 582 C CG . GLN A 1 93 ? 36.095 -9.594 -29.160 1.00 21.21 ? 77 GLN A CG 1 ATOM 583 C CD . GLN A 1 93 ? 36.406 -8.111 -29.199 1.00 23.02 ? 77 GLN A CD 1 ATOM 584 O OE1 . GLN A 1 93 ? 37.540 -7.722 -29.466 1.00 26.33 ? 77 GLN A OE1 1 ATOM 585 N NE2 . GLN A 1 93 ? 35.397 -7.274 -28.939 1.00 15.59 ? 77 GLN A NE2 1 ATOM 586 N N . GLY A 1 94 ? 39.036 -11.505 -25.706 1.00 12.40 ? 78 GLY A N 1 ATOM 587 C CA . GLY A 1 94 ? 39.657 -11.413 -24.397 1.00 10.92 ? 78 GLY A CA 1 ATOM 588 C C . GLY A 1 94 ? 38.754 -11.734 -23.229 1.00 11.41 ? 78 GLY A C 1 ATOM 589 O O . GLY A 1 94 ? 37.663 -12.239 -23.410 1.00 13.39 ? 78 GLY A O 1 ATOM 590 N N . GLU A 1 95 ? 39.225 -11.439 -22.019 1.00 12.37 ? 79 GLU A N 1 ATOM 591 C CA . GLU A 1 95 ? 38.542 -11.828 -20.784 1.00 13.18 ? 79 GLU A CA 1 ATOM 592 C C . GLU A 1 95 ? 37.443 -10.859 -20.385 1.00 12.00 ? 79 GLU A C 1 ATOM 593 O O . GLU A 1 95 ? 37.630 -9.648 -20.367 1.00 14.69 ? 79 GLU A O 1 ATOM 594 C CB . GLU A 1 95 ? 39.549 -11.971 -19.642 1.00 16.33 ? 79 GLU A CB 1 ATOM 595 C CG . GLU A 1 95 ? 38.899 -12.132 -18.281 1.00 18.71 ? 79 GLU A CG 1 ATOM 596 C CD . GLU A 1 95 ? 39.879 -12.362 -17.156 1.00 23.64 ? 79 GLU A CD 1 ATOM 597 O OE1 . GLU A 1 95 ? 40.250 -13.533 -16.928 1.00 27.13 ? 79 GLU A OE1 1 ATOM 598 O OE2 . GLU A 1 95 ? 40.253 -11.383 -16.479 1.00 25.98 ? 79 GLU A OE2 1 ATOM 599 N N . ALA A 1 96 ? 36.287 -11.414 -20.066 1.00 12.16 ? 80 ALA A N 1 ATOM 600 C CA . ALA A 1 96 ? 35.140 -10.631 -19.644 1.00 14.77 ? 80 ALA A CA 1 ATOM 601 C C . ALA A 1 96 ? 35.358 -10.091 -18.237 1.00 15.06 ? 80 ALA A C 1 ATOM 602 O O . ALA A 1 96 ? 36.028 -10.714 -17.422 1.00 14.70 ? 80 ALA A O 1 ATOM 603 C CB . ALA A 1 96 ? 33.895 -11.483 -19.686 1.00 10.25 ? 80 ALA A CB 1 ATOM 604 N N . THR A 1 97 ? 34.755 -8.942 -17.952 1.00 19.76 ? 81 THR A N 1 ATOM 605 C CA . THR A 1 97 ? 35.040 -8.177 -16.744 1.00 15.73 ? 81 THR A CA 1 ATOM 606 C C . THR A 1 97 ? 33.822 -7.396 -16.316 1.00 10.03 ? 81 THR A C 1 ATOM 607 O O . THR A 1 97 ? 33.112 -6.879 -17.153 1.00 12.65 ? 81 THR A O 1 ATOM 608 C CB . THR A 1 97 ? 36.176 -7.171 -17.022 1.00 20.82 ? 81 THR A CB 1 ATOM 609 O OG1 . THR A 1 97 ? 37.414 -7.710 -16.552 1.00 28.72 ? 81 THR A OG1 1 ATOM 610 C CG2 . THR A 1 97 ? 35.919 -5.842 -16.335 1.00 21.81 ? 81 THR A CG2 1 ATOM 611 N N . LEU A 1 98 ? 33.599 -7.294 -15.013 1.00 12.69 ? 82 LEU A N 1 ATOM 612 C CA . LEU A 1 98 ? 32.530 -6.472 -14.470 1.00 10.09 ? 82 LEU A CA 1 ATOM 613 C C . LEU A 1 98 ? 33.126 -5.756 -13.309 1.00 12.52 ? 82 LEU A C 1 ATOM 614 O O . LEU A 1 98 ? 33.915 -6.338 -12.590 1.00 14.06 ? 82 LEU A O 1 ATOM 615 C CB . LEU A 1 98 ? 31.368 -7.323 -13.952 1.00 10.73 ? 82 LEU A CB 1 ATOM 616 C CG . LEU A 1 98 ? 30.517 -8.083 -14.968 1.00 10.18 ? 82 LEU A CG 1 ATOM 617 C CD1 . LEU A 1 98 ? 29.740 -9.142 -14.267 1.00 9.32 ? 82 LEU A CD1 1 ATOM 618 C CD2 . LEU A 1 98 ? 29.589 -7.149 -15.707 1.00 9.82 ? 82 LEU A CD2 1 ATOM 619 N N . VAL A 1 99 ? 32.730 -4.506 -13.096 1.00 16.66 ? 83 VAL A N 1 ATOM 620 C CA . VAL A 1 99 ? 33.224 -3.722 -11.959 1.00 14.39 ? 83 VAL A CA 1 ATOM 621 C C . VAL A 1 99 ? 32.772 -4.300 -10.636 1.00 14.75 ? 83 VAL A C 1 ATOM 622 O O . VAL A 1 99 ? 33.413 -4.100 -9.620 1.00 13.89 ? 83 VAL A O 1 ATOM 623 C CB . VAL A 1 99 ? 32.753 -2.264 -12.030 1.00 14.90 ? 83 VAL A CB 1 ATOM 624 C CG1 . VAL A 1 99 ? 33.279 -1.617 -13.302 1.00 15.02 ? 83 VAL A CG1 1 ATOM 625 C CG2 . VAL A 1 99 ? 31.231 -2.173 -11.933 1.00 15.08 ? 83 VAL A CG2 1 ATOM 626 N N . GLU A 1 100 ? 31.665 -5.022 -10.646 1.00 15.54 ? 84 GLU A N 1 ATOM 627 C CA . GLU A 1 100 ? 31.157 -5.602 -9.412 1.00 16.03 ? 84 GLU A CA 1 ATOM 628 C C . GLU A 1 100 ? 32.006 -6.769 -8.933 1.00 13.00 ? 84 GLU A C 1 ATOM 629 O O . GLU A 1 100 ? 31.834 -7.235 -7.822 1.00 12.67 ? 84 GLU A O 1 ATOM 630 C CB . GLU A 1 100 ? 29.678 -6.012 -9.516 1.00 14.03 ? 84 GLU A CB 1 ATOM 631 C CG . GLU A 1 100 ? 29.145 -6.303 -10.906 1.00 19.15 ? 84 GLU A CG 1 ATOM 632 C CD . GLU A 1 100 ? 28.768 -5.058 -11.680 1.00 13.86 ? 84 GLU A CD 1 ATOM 633 O OE1 . GLU A 1 100 ? 29.452 -4.758 -12.668 1.00 17.71 ? 84 GLU A OE1 1 ATOM 634 O OE2 . GLU A 1 100 ? 27.771 -4.399 -11.335 1.00 19.49 ? 84 GLU A OE2 1 ATOM 635 N N . GLU A 1 101 ? 32.924 -7.221 -9.773 1.00 12.99 ? 85 GLU A N 1 ATOM 636 C CA . GLU A 1 101 ? 33.949 -8.170 -9.367 1.00 14.74 ? 85 GLU A CA 1 ATOM 637 C C . GLU A 1 101 ? 34.720 -7.703 -8.136 1.00 18.25 ? 85 GLU A C 1 ATOM 638 O O . GLU A 1 101 ? 35.251 -8.529 -7.401 1.00 15.62 ? 85 GLU A O 1 ATOM 639 C CB . GLU A 1 101 ? 34.962 -8.349 -10.493 1.00 18.33 ? 85 GLU A CB 1 ATOM 640 C CG . GLU A 1 101 ? 35.089 -9.734 -11.058 1.00 20.01 ? 85 GLU A CG 1 ATOM 641 C CD . GLU A 1 101 ? 36.008 -9.759 -12.276 1.00 17.84 ? 85 GLU A CD 1 ATOM 642 O OE1 . GLU A 1 101 ? 35.683 -9.090 -13.286 1.00 16.59 ? 85 GLU A OE1 1 ATOM 643 O OE2 . GLU A 1 101 ? 37.057 -10.433 -12.216 1.00 24.18 ? 85 GLU A OE2 1 ATOM 644 N N . GLN A 1 102 ? 34.805 -6.385 -7.940 1.00 20.15 ? 86 GLN A N 1 ATOM 645 C CA . GLN A 1 102 ? 35.547 -5.786 -6.822 1.00 21.11 ? 86 GLN A CA 1 ATOM 646 C C . GLN A 1 102 ? 34.592 -5.315 -5.709 1.00 24.03 ? 86 GLN A C 1 ATOM 647 O O . GLN A 1 102 ? 34.973 -4.537 -4.832 1.00 23.43 ? 86 GLN A O 1 ATOM 648 C CB . GLN A 1 102 ? 36.411 -4.609 -7.309 1.00 22.49 ? 86 GLN A CB 1 ATOM 649 C CG . GLN A 1 102 ? 37.130 -4.827 -8.664 1.00 33.84 ? 86 GLN A CG 1 ATOM 650 C CD . GLN A 1 102 ? 38.593 -5.257 -8.537 1.00 42.92 ? 86 GLN A CD 1 ATOM 651 O OE1 . GLN A 1 102 ? 39.049 -5.640 -7.459 1.00 39.60 ? 86 GLN A OE1 1 ATOM 652 N NE2 . GLN A 1 102 ? 39.335 -5.190 -9.650 1.00 48.89 ? 86 GLN A NE2 1 ATOM 653 N N . ASP A 1 103 ? 33.357 -5.817 -5.749 1.00 19.95 ? 87 ASP A N 1 ATOM 654 C CA . ASP A 1 103 ? 32.313 -5.467 -4.795 1.00 19.79 ? 87 ASP A CA 1 ATOM 655 C C . ASP A 1 103 ? 32.023 -6.674 -3.908 1.00 17.34 ? 87 ASP A C 1 ATOM 656 O O . ASP A 1 103 ? 31.649 -7.737 -4.382 1.00 17.06 ? 87 ASP A O 1 ATOM 657 C CB . ASP A 1 103 ? 31.044 -5.034 -5.543 1.00 19.19 ? 87 ASP A CB 1 ATOM 658 C CG . ASP A 1 103 ? 30.018 -4.376 -4.642 1.00 22.22 ? 87 ASP A CG 1 ATOM 659 O OD1 . ASP A 1 103 ? 29.863 -4.810 -3.485 1.00 20.80 ? 87 ASP A OD1 1 ATOM 660 O OD2 . ASP A 1 103 ? 29.356 -3.423 -5.103 1.00 24.57 ? 87 ASP A OD2 1 ATOM 661 N N . THR A 1 104 ? 32.201 -6.498 -2.610 1.00 23.96 ? 88 THR A N 1 ATOM 662 C CA . THR A 1 104 ? 32.078 -7.605 -1.672 1.00 22.56 ? 88 THR A CA 1 ATOM 663 C C . THR A 1 104 ? 30.631 -7.949 -1.332 1.00 19.45 ? 88 THR A C 1 ATOM 664 O O . THR A 1 104 ? 30.369 -8.962 -0.684 1.00 19.10 ? 88 THR A O 1 ATOM 665 C CB . THR A 1 104 ? 32.830 -7.306 -0.382 1.00 22.38 ? 88 THR A CB 1 ATOM 666 O OG1 . THR A 1 104 ? 32.374 -6.061 0.159 1.00 19.83 ? 88 THR A OG1 1 ATOM 667 C CG2 . THR A 1 104 ? 34.331 -7.245 -0.659 1.00 24.40 ? 88 THR A CG2 1 ATOM 668 N N . ASN A 1 105 ? 29.696 -7.103 -1.757 1.00 17.58 ? 89 ASN A N 1 ATOM 669 C CA . ASN A 1 105 ? 28.289 -7.471 -1.735 1.00 17.93 ? 89 ASN A CA 1 ATOM 670 C C . ASN A 1 105 ? 27.964 -8.416 -2.867 1.00 14.81 ? 89 ASN A C 1 ATOM 671 O O . ASN A 1 105 ? 26.900 -9.003 -2.891 1.00 13.47 ? 89 ASN A O 1 ATOM 672 C CB . ASN A 1 105 ? 27.402 -6.250 -1.880 1.00 21.99 ? 89 ASN A CB 1 ATOM 673 C CG . ASN A 1 105 ? 27.288 -5.459 -0.605 1.00 25.49 ? 89 ASN A CG 1 ATOM 674 O OD1 . ASN A 1 105 ? 26.945 -6.001 0.441 1.00 25.72 ? 89 ASN A OD1 1 ATOM 675 N ND2 . ASN A 1 105 ? 27.582 -4.162 -0.682 1.00 30.23 ? 89 ASN A ND2 1 ATOM 676 N N . PHE A 1 106 ? 28.889 -8.564 -3.807 1.00 18.03 ? 90 PHE A N 1 ATOM 677 C CA . PHE A 1 106 ? 28.645 -9.400 -4.975 1.00 15.22 ? 90 PHE A CA 1 ATOM 678 C C . PHE A 1 106 ? 29.373 -10.730 -4.938 1.00 17.40 ? 90 PHE A C 1 ATOM 679 O O . PHE A 1 106 ? 30.520 -10.809 -4.502 1.00 22.11 ? 90 PHE A O 1 ATOM 680 C CB . PHE A 1 106 ? 29.001 -8.650 -6.241 1.00 12.33 ? 90 PHE A CB 1 ATOM 681 C CG . PHE A 1 106 ? 27.927 -7.713 -6.696 1.00 14.03 ? 90 PHE A CG 1 ATOM 682 C CD1 . PHE A 1 106 ? 27.829 -6.431 -6.169 1.00 14.90 ? 90 PHE A CD1 1 ATOM 683 C CD2 . PHE A 1 106 ? 27.007 -8.109 -7.642 1.00 12.78 ? 90 PHE A CD2 1 ATOM 684 C CE1 . PHE A 1 106 ? 26.823 -5.560 -6.588 1.00 15.87 ? 90 PHE A CE1 1 ATOM 685 C CE2 . PHE A 1 106 ? 26.014 -7.253 -8.066 1.00 12.29 ? 90 PHE A CE2 1 ATOM 686 C CZ . PHE A 1 106 ? 25.922 -5.974 -7.540 1.00 16.41 ? 90 PHE A CZ 1 ATOM 687 N N . VAL A 1 107 ? 28.670 -11.769 -5.393 1.00 15.07 ? 91 VAL A N 1 ATOM 688 C CA . VAL A 1 107 ? 29.242 -13.101 -5.594 1.00 15.70 ? 91 VAL A CA 1 ATOM 689 C C . VAL A 1 107 ? 29.375 -13.381 -7.106 1.00 15.04 ? 91 VAL A C 1 ATOM 690 O O . VAL A 1 107 ? 28.426 -13.213 -7.871 1.00 14.60 ? 91 VAL A O 1 ATOM 691 C CB . VAL A 1 107 ? 28.407 -14.178 -4.882 1.00 14.20 ? 91 VAL A CB 1 ATOM 692 C CG1 . VAL A 1 107 ? 26.960 -14.132 -5.342 1.00 13.93 ? 91 VAL A CG1 1 ATOM 693 C CG2 . VAL A 1 107 ? 29.017 -15.547 -5.103 1.00 19.02 ? 91 VAL A CG2 1 ATOM 694 N N . CYS A 1 108 ? 30.568 -13.776 -7.531 1.00 14.39 ? 92 CYS A N 1 ATOM 695 C CA . CYS A 1 108 ? 30.911 -13.782 -8.944 1.00 13.64 ? 92 CYS A CA 1 ATOM 696 C C . CYS A 1 108 ? 31.423 -15.133 -9.388 1.00 14.08 ? 92 CYS A C 1 ATOM 697 O O . CYS A 1 108 ? 31.934 -15.892 -8.598 1.00 18.39 ? 92 CYS A O 1 ATOM 698 C CB . CYS A 1 108 ? 31.986 -12.724 -9.233 1.00 12.95 ? 92 CYS A CB 1 ATOM 699 S SG . CYS A 1 108 ? 31.460 -10.992 -9.130 1.00 17.88 ? 92 CYS A SG 1 ATOM 700 N N . ARG A 1 109 ? 31.299 -15.424 -10.670 1.00 13.94 ? 93 ARG A N 1 ATOM 701 C CA . ARG A 1 109 ? 31.781 -16.674 -11.212 1.00 13.60 ? 93 ARG A CA 1 ATOM 702 C C . ARG A 1 109 ? 32.246 -16.465 -12.637 1.00 12.36 ? 93 ARG A C 1 ATOM 703 O O . ARG A 1 109 ? 31.565 -15.808 -13.409 1.00 11.91 ? 93 ARG A O 1 ATOM 704 C CB . ARG A 1 109 ? 30.672 -17.730 -11.175 1.00 17.05 ? 93 ARG A CB 1 ATOM 705 C CG . ARG A 1 109 ? 31.144 -19.128 -11.549 1.00 18.80 ? 93 ARG A CG 1 ATOM 706 C CD . ARG A 1 109 ? 30.465 -20.244 -10.741 1.00 27.45 ? 93 ARG A CD 1 ATOM 707 N NE . ARG A 1 109 ? 30.506 -20.006 -9.295 1.00 33.75 ? 93 ARG A NE 1 ATOM 708 C CZ . ARG A 1 109 ? 29.936 -20.788 -8.379 1.00 26.82 ? 93 ARG A CZ 1 ATOM 709 N NH1 . ARG A 1 109 ? 29.284 -21.882 -8.750 1.00 26.87 ? 93 ARG A NH1 1 ATOM 710 N NH2 . ARG A 1 109 ? 30.026 -20.474 -7.091 1.00 23.07 ? 93 ARG A NH2 1 ATOM 711 N N . ARG A 1 110 ? 33.403 -17.043 -12.964 1.00 11.87 ? 94 ARG A N 1 ATOM 712 C CA . ARG A 1 110 ? 33.977 -17.016 -14.302 1.00 12.27 ? 94 ARG A CA 1 ATOM 713 C C . ARG A 1 110 ? 33.903 -18.379 -14.969 1.00 11.52 ? 94 ARG A C 1 ATOM 714 O O . ARG A 1 110 ? 34.052 -19.391 -14.305 1.00 11.80 ? 94 ARG A O 1 ATOM 715 C CB . ARG A 1 110 ? 35.450 -16.611 -14.230 1.00 15.21 ? 94 ARG A CB 1 ATOM 716 C CG . ARG A 1 110 ? 35.691 -15.149 -13.987 1.00 18.97 ? 94 ARG A CG 1 ATOM 717 C CD . ARG A 1 110 ? 37.086 -14.742 -14.433 1.00 19.76 ? 94 ARG A CD 1 ATOM 718 N NE . ARG A 1 110 ? 37.243 -13.294 -14.466 1.00 19.13 ? 94 ARG A NE 1 ATOM 719 C CZ . ARG A 1 110 ? 36.934 -12.534 -15.506 1.00 18.19 ? 94 ARG A CZ 1 ATOM 720 N NH1 . ARG A 1 110 ? 36.446 -13.078 -16.616 1.00 17.05 ? 94 ARG A NH1 1 ATOM 721 N NH2 . ARG A 1 110 ? 37.118 -11.228 -15.433 1.00 19.41 ? 94 ARG A NH2 1 ATOM 722 N N . THR A 1 111 ? 33.674 -18.387 -16.286 1.00 16.13 ? 95 THR A N 1 ATOM 723 C CA . THR A 1 111 ? 33.773 -19.576 -17.146 1.00 13.30 ? 95 THR A CA 1 ATOM 724 C C . THR A 1 111 ? 34.125 -19.208 -18.576 1.00 11.41 ? 95 THR A C 1 ATOM 725 O O . THR A 1 111 ? 34.393 -18.059 -18.903 1.00 13.01 ? 95 THR A O 1 ATOM 726 C CB . THR A 1 111 ? 32.442 -20.321 -17.343 1.00 12.45 ? 95 THR A CB 1 ATOM 727 O OG1 . THR A 1 111 ? 31.421 -19.758 -16.524 1.00 23.45 ? 95 THR A OG1 1 ATOM 728 C CG2 . THR A 1 111 ? 32.616 -21.803 -17.093 1.00 14.52 ? 95 THR A CG2 1 ATOM 729 N N . PHE A 1 112 ? 34.080 -20.220 -19.426 1.00 11.43 ? 96 PHE A N 1 ATOM 730 C CA . PHE A 1 112 ? 34.070 -20.044 -20.866 1.00 11.38 ? 96 PHE A CA 1 ATOM 731 C C . PHE A 1 112 ? 32.859 -20.759 -21.426 1.00 12.05 ? 96 PHE A C 1 ATOM 732 O O . PHE A 1 112 ? 32.504 -21.833 -20.953 1.00 12.50 ? 96 PHE A O 1 ATOM 733 C CB . PHE A 1 112 ? 35.341 -20.608 -21.456 1.00 12.67 ? 96 PHE A CB 1 ATOM 734 C CG . PHE A 1 112 ? 36.558 -19.916 -20.970 1.00 12.02 ? 96 PHE A CG 1 ATOM 735 C CD1 . PHE A 1 112 ? 37.151 -20.300 -19.782 1.00 16.36 ? 96 PHE A CD1 1 ATOM 736 C CD2 . PHE A 1 112 ? 37.097 -18.866 -21.676 1.00 12.84 ? 96 PHE A CD2 1 ATOM 737 C CE1 . PHE A 1 112 ? 38.273 -19.650 -19.307 1.00 19.16 ? 96 PHE A CE1 1 ATOM 738 C CE2 . PHE A 1 112 ? 38.216 -18.204 -21.207 1.00 19.10 ? 96 PHE A CE2 1 ATOM 739 C CZ . PHE A 1 112 ? 38.806 -18.599 -20.013 1.00 16.91 ? 96 PHE A CZ 1 ATOM 740 N N . VAL A 1 113 ? 32.216 -20.143 -22.414 1.00 12.19 ? 97 VAL A N 1 ATOM 741 C CA . VAL A 1 113 ? 30.997 -20.674 -23.017 1.00 10.62 ? 97 VAL A CA 1 ATOM 742 C C . VAL A 1 113 ? 31.200 -20.775 -24.514 1.00 10.79 ? 97 VAL A C 1 ATOM 743 O O . VAL A 1 113 ? 32.083 -20.133 -25.070 1.00 10.18 ? 97 VAL A O 1 ATOM 744 C CB . VAL A 1 113 ? 29.770 -19.770 -22.740 1.00 9.56 ? 97 VAL A CB 1 ATOM 745 C CG1 . VAL A 1 113 ? 29.436 -19.761 -21.284 1.00 13.65 ? 97 VAL A CG1 1 ATOM 746 C CG2 . VAL A 1 113 ? 30.017 -18.340 -23.235 1.00 10.47 ? 97 VAL A CG2 1 ATOM 747 N N . ASP A 1 114 ? 30.388 -21.591 -25.175 1.00 13.15 ? 98 ASP A N 1 ATOM 748 C CA . ASP A 1 114 ? 30.445 -21.691 -26.625 1.00 11.83 ? 98 ASP A CA 1 ATOM 749 C C . ASP A 1 114 ? 29.918 -20.375 -27.175 1.00 11.11 ? 98 ASP A C 1 ATOM 750 O O . ASP A 1 114 ? 28.905 -19.857 -26.680 1.00 10.78 ? 98 ASP A O 1 ATOM 751 C CB . ASP A 1 114 ? 29.574 -22.842 -27.147 1.00 16.85 ? 98 ASP A CB 1 ATOM 752 C CG . ASP A 1 114 ? 30.053 -24.221 -26.688 1.00 16.30 ? 98 ASP A CG 1 ATOM 753 O OD1 . ASP A 1 114 ? 30.979 -24.303 -25.864 1.00 16.98 ? 98 ASP A OD1 1 ATOM 754 O OD2 . ASP A 1 114 ? 29.493 -25.227 -27.159 1.00 18.11 ? 98 ASP A OD2 1 ATOM 755 N N . ARG A 1 115 ? 30.621 -19.851 -28.179 1.00 11.32 ? 99 ARG A N 1 ATOM 756 C CA . ARG A 1 115 ? 30.222 -18.664 -28.936 1.00 10.70 ? 99 ARG A CA 1 ATOM 757 C C . ARG A 1 115 ? 30.371 -19.034 -30.393 1.00 9.18 ? 99 ARG A C 1 ATOM 758 O O . ARG A 1 115 ? 31.124 -19.944 -30.710 1.00 14.47 ? 99 ARG A O 1 ATOM 759 C CB . ARG A 1 115 ? 31.134 -17.473 -28.611 1.00 7.82 ? 99 ARG A CB 1 ATOM 760 C CG . ARG A 1 115 ? 31.070 -16.934 -27.180 1.00 8.72 ? 99 ARG A CG 1 ATOM 761 C CD . ARG A 1 115 ? 29.649 -16.508 -26.732 1.00 8.47 ? 99 ARG A CD 1 ATOM 762 N NE . ARG A 1 115 ? 29.026 -15.448 -27.537 1.00 8.27 ? 99 ARG A NE 1 ATOM 763 C CZ . ARG A 1 115 ? 29.146 -14.143 -27.306 1.00 8.19 ? 99 ARG A CZ 1 ATOM 764 N NH1 . ARG A 1 115 ? 29.900 -13.697 -26.317 1.00 9.64 ? 99 ARG A NH1 1 ATOM 765 N NH2 . ARG A 1 115 ? 28.517 -13.274 -28.074 1.00 11.63 ? 99 ARG A NH2 1 ATOM 766 N N . GLY A 1 116 ? 29.666 -18.356 -31.286 1.00 10.02 ? 100 GLY A N 1 ATOM 767 C CA . GLY A 1 116 ? 29.778 -18.630 -32.709 1.00 8.49 ? 100 GLY A CA 1 ATOM 768 C C . GLY A 1 116 ? 28.834 -17.729 -33.484 1.00 9.34 ? 100 GLY A C 1 ATOM 769 O O . GLY A 1 116 ? 28.269 -16.804 -32.921 1.00 9.15 ? 100 GLY A O 1 ATOM 770 N N . HIS A 1 117 ? 28.631 -18.025 -34.762 1.00 8.67 ? 101 HIS A N 1 ATOM 771 C CA . HIS A 1 117 ? 27.853 -17.166 -35.632 1.00 10.02 ? 101 HIS A CA 1 ATOM 772 C C . HIS A 1 117 ? 26.452 -16.909 -35.073 1.00 9.82 ? 101 HIS A C 1 ATOM 773 O O . HIS A 1 117 ? 25.895 -15.845 -35.252 1.00 11.84 ? 101 HIS A O 1 ATOM 774 C CB . HIS A 1 117 ? 27.782 -17.770 -37.054 1.00 14.92 ? 101 HIS A CB 1 ATOM 775 C CG . HIS A 1 117 ? 29.116 -17.996 -37.703 1.00 21.19 ? 101 HIS A CG 1 ATOM 776 N ND1 . HIS A 1 117 ? 29.264 -18.626 -38.927 1.00 17.41 ? 101 HIS A ND1 1 ATOM 777 C CD2 . HIS A 1 117 ? 30.378 -17.675 -37.300 1.00 17.76 ? 101 HIS A CD2 1 ATOM 778 C CE1 . HIS A 1 117 ? 30.539 -18.675 -39.245 1.00 20.57 ? 101 HIS A CE1 1 ATOM 779 N NE2 . HIS A 1 117 ? 31.239 -18.114 -38.279 1.00 16.34 ? 101 HIS A NE2 1 ATOM 780 N N . GLY A 1 118 ? 25.870 -17.879 -34.390 1.00 9.53 ? 102 GLY A N 1 ATOM 781 C CA . GLY A 1 118 ? 24.504 -17.744 -33.923 1.00 10.11 ? 102 GLY A CA 1 ATOM 782 C C . GLY A 1 118 ? 24.321 -16.760 -32.782 1.00 13.15 ? 102 GLY A C 1 ATOM 783 O O . GLY A 1 118 ? 23.199 -16.407 -32.445 1.00 12.14 ? 102 GLY A O 1 ATOM 784 N N . ASN A 1 119 ? 25.419 -16.332 -32.171 1.00 11.71 ? 103 ASN A N 1 ATOM 785 C CA . ASN A 1 119 ? 25.359 -15.334 -31.112 1.00 12.20 ? 103 ASN A CA 1 ATOM 786 C C . ASN A 1 119 ? 26.371 -14.181 -31.290 1.00 10.85 ? 103 ASN A C 1 ATOM 787 O O . ASN A 1 119 ? 26.874 -13.620 -30.317 1.00 11.46 ? 103 ASN A O 1 ATOM 788 C CB . ASN A 1 119 ? 25.514 -16.004 -29.740 1.00 11.50 ? 103 ASN A CB 1 ATOM 789 C CG . ASN A 1 119 ? 26.601 -17.062 -29.718 1.00 7.63 ? 103 ASN A CG 1 ATOM 790 O OD1 . ASN A 1 119 ? 27.788 -16.756 -29.784 1.00 7.62 ? 103 ASN A OD1 1 ATOM 791 N ND2 . ASN A 1 119 ? 26.199 -18.315 -29.611 1.00 9.41 ? 103 ASN A ND2 1 ATOM 792 N N . GLY A 1 120 ? 26.658 -13.839 -32.539 1.00 10.82 ? 104 GLY A N 1 ATOM 793 C CA . GLY A 1 120 ? 27.364 -12.616 -32.849 1.00 13.05 ? 104 GLY A CA 1 ATOM 794 C C . GLY A 1 120 ? 28.857 -12.712 -33.048 1.00 12.02 ? 104 GLY A C 1 ATOM 795 O O . GLY A 1 120 ? 29.499 -11.711 -33.317 1.00 16.34 ? 104 GLY A O 1 ATOM 796 N N . CYS A 1 121 ? 29.430 -13.899 -32.929 1.00 12.71 ? 105 CYS A N 1 ATOM 797 C CA . CYS A 1 121 ? 30.879 -14.018 -33.036 1.00 11.21 ? 105 CYS A CA 1 ATOM 798 C C . CYS A 1 121 ? 31.308 -14.522 -34.408 1.00 13.06 ? 105 CYS A C 1 ATOM 799 O O . CYS A 1 121 ? 30.615 -15.322 -35.020 1.00 13.84 ? 105 CYS A O 1 ATOM 800 C CB . CYS A 1 121 ? 31.404 -14.908 -31.928 1.00 7.70 ? 105 CYS A CB 1 ATOM 801 S SG . CYS A 1 121 ? 30.929 -14.305 -30.330 1.00 10.62 ? 105 CYS A SG 1 ATOM 802 N N . GLY A 1 122 ? 32.432 -14.016 -34.905 1.00 12.11 ? 106 GLY A N 1 ATOM 803 C CA . GLY A 1 122 ? 32.941 -14.421 -36.202 1.00 12.45 ? 106 GLY A CA 1 ATOM 804 C C . GLY A 1 122 ? 33.540 -15.814 -36.204 1.00 13.24 ? 106 GLY A C 1 ATOM 805 O O . GLY A 1 122 ? 33.677 -16.429 -37.253 1.00 16.32 ? 106 GLY A O 1 ATOM 806 N N . LEU A 1 123 ? 33.883 -16.321 -35.029 1.00 10.82 ? 107 LEU A N 1 ATOM 807 C CA . LEU A 1 123 ? 34.442 -17.654 -34.916 1.00 12.29 ? 107 LEU A CA 1 ATOM 808 C C . LEU A 1 123 ? 33.604 -18.527 -34.009 1.00 12.25 ? 107 LEU A C 1 ATOM 809 O O . LEU A 1 123 ? 32.986 -18.032 -33.082 1.00 10.42 ? 107 LEU A O 1 ATOM 810 C CB . LEU A 1 123 ? 35.838 -17.587 -34.309 1.00 13.89 ? 107 LEU A CB 1 ATOM 811 C CG . LEU A 1 123 ? 36.987 -17.138 -35.196 1.00 21.30 ? 107 LEU A CG 1 ATOM 812 C CD1 . LEU A 1 123 ? 38.264 -17.235 -34.373 1.00 19.43 ? 107 LEU A CD1 1 ATOM 813 C CD2 . LEU A 1 123 ? 37.081 -17.987 -36.478 1.00 27.27 ? 107 LEU A CD2 1 ATOM 814 N N . PHE A 1 124 ? 33.612 -19.828 -34.270 1.00 11.26 ? 108 PHE A N 1 ATOM 815 C CA . PHE A 1 124 ? 33.137 -20.786 -33.294 1.00 9.00 ? 108 PHE A CA 1 ATOM 816 C C . PHE A 1 124 ? 34.260 -21.103 -32.313 1.00 10.61 ? 108 PHE A C 1 ATOM 817 O O . PHE A 1 124 ? 35.381 -21.425 -32.692 1.00 13.62 ? 108 PHE A O 1 ATOM 818 C CB . PHE A 1 124 ? 32.655 -22.065 -33.971 1.00 11.53 ? 108 PHE A CB 1 ATOM 819 C CG . PHE A 1 124 ? 31.441 -21.883 -34.835 1.00 10.76 ? 108 PHE A CG 1 ATOM 820 C CD1 . PHE A 1 124 ? 30.182 -21.877 -34.277 1.00 9.85 ? 108 PHE A CD1 1 ATOM 821 C CD2 . PHE A 1 124 ? 31.552 -21.750 -36.199 1.00 11.62 ? 108 PHE A CD2 1 ATOM 822 C CE1 . PHE A 1 124 ? 29.065 -21.720 -35.046 1.00 7.98 ? 108 PHE A CE1 1 ATOM 823 C CE2 . PHE A 1 124 ? 30.430 -21.597 -36.979 1.00 10.20 ? 108 PHE A CE2 1 ATOM 824 C CZ . PHE A 1 124 ? 29.187 -21.575 -36.397 1.00 11.40 ? 108 PHE A CZ 1 ATOM 825 N N . GLY A 1 125 ? 33.962 -21.017 -31.034 1.00 10.35 ? 109 GLY A N 1 ATOM 826 C CA . GLY A 1 125 ? 34.962 -21.295 -30.022 1.00 15.90 ? 109 GLY A CA 1 ATOM 827 C C . GLY A 1 125 ? 34.432 -20.954 -28.644 1.00 10.92 ? 109 GLY A C 1 ATOM 828 O O . GLY A 1 125 ? 33.246 -20.732 -28.473 1.00 11.26 ? 109 GLY A O 1 ATOM 829 N N . LYS A 1 126 ? 35.314 -20.924 -27.660 1.00 11.43 ? 110 LYS A N 1 ATOM 830 C CA . LYS A 1 126 ? 34.920 -20.547 -26.318 1.00 11.33 ? 110 LYS A CA 1 ATOM 831 C C . LYS A 1 126 ? 35.139 -19.045 -26.118 1.00 11.24 ? 110 LYS A C 1 ATOM 832 O O . LYS A 1 126 ? 36.158 -18.500 -26.507 1.00 10.81 ? 110 LYS A O 1 ATOM 833 C CB . LYS A 1 126 ? 35.723 -21.335 -25.291 1.00 12.35 ? 110 LYS A CB 1 ATOM 834 C CG . LYS A 1 126 ? 35.642 -22.828 -25.443 1.00 11.11 ? 110 LYS A CG 1 ATOM 835 C CD . LYS A 1 126 ? 34.322 -23.369 -24.953 1.00 13.23 ? 110 LYS A CD 1 ATOM 836 C CE . LYS A 1 126 ? 34.316 -24.907 -24.917 1.00 12.68 ? 110 LYS A CE 1 ATOM 837 N NZ . LYS A 1 126 ? 32.926 -25.462 -24.925 1.00 11.26 ? 110 LYS A NZ 1 ATOM 838 N N . GLY A 1 127 ? 34.152 -18.392 -25.529 1.00 10.52 ? 111 GLY A N 1 ATOM 839 C CA . GLY A 1 127 ? 34.222 -16.990 -25.199 1.00 11.14 ? 111 GLY A CA 1 ATOM 840 C C . GLY A 1 127 ? 34.221 -16.849 -23.693 1.00 14.29 ? 111 GLY A C 1 ATOM 841 O O . GLY A 1 127 ? 33.587 -17.644 -23.011 1.00 13.81 ? 111 GLY A O 1 ATOM 842 N N . SER A 1 128 ? 34.930 -15.850 -23.168 1.00 10.03 ? 112 SER A N 1 ATOM 843 C CA . SER A 1 128 ? 34.967 -15.617 -21.731 1.00 10.14 ? 112 SER A CA 1 ATOM 844 C C . SER A 1 128 ? 33.613 -15.142 -21.249 1.00 10.98 ? 112 SER A C 1 ATOM 845 O O . SER A 1 128 ? 32.911 -14.448 -21.968 1.00 12.62 ? 112 SER A O 1 ATOM 846 C CB . SER A 1 128 ? 36.018 -14.561 -21.381 1.00 11.77 ? 112 SER A CB 1 ATOM 847 O OG . SER A 1 128 ? 36.004 -14.256 -19.987 1.00 13.91 ? 112 SER A OG 1 ATOM 848 N N . LEU A 1 129 ? 33.247 -15.512 -20.025 1.00 10.68 ? 113 LEU A N 1 ATOM 849 C CA . LEU A 1 129 ? 32.014 -15.037 -19.445 1.00 8.96 ? 113 LEU A CA 1 ATOM 850 C C . LEU A 1 129 ? 32.227 -14.801 -17.966 1.00 10.41 ? 113 LEU A C 1 ATOM 851 O O . LEU A 1 129 ? 32.919 -15.577 -17.334 1.00 11.26 ? 113 LEU A O 1 ATOM 852 C CB . LEU A 1 129 ? 30.906 -16.060 -19.674 1.00 9.39 ? 113 LEU A CB 1 ATOM 853 C CG . LEU A 1 129 ? 29.519 -15.579 -19.260 1.00 10.05 ? 113 LEU A CG 1 ATOM 854 C CD1 . LEU A 1 129 ? 28.494 -15.896 -20.311 1.00 10.58 ? 113 LEU A CD1 1 ATOM 855 C CD2 . LEU A 1 129 ? 29.125 -16.200 -17.945 1.00 10.04 ? 113 LEU A CD2 1 ATOM 856 N N . ILE A 1 130 ? 31.660 -13.721 -17.428 1.00 10.56 ? 114 ILE A N 1 ATOM 857 C CA . ILE A 1 130 ? 31.675 -13.455 -15.986 1.00 10.40 ? 114 ILE A CA 1 ATOM 858 C C . ILE A 1 130 ? 30.263 -13.078 -15.547 1.00 7.82 ? 114 ILE A C 1 ATOM 859 O O . ILE A 1 130 ? 29.593 -12.318 -16.203 1.00 7.97 ? 114 ILE A O 1 ATOM 860 C CB . ILE A 1 130 ? 32.742 -12.341 -15.587 1.00 13.75 ? 114 ILE A CB 1 ATOM 861 C CG1 . ILE A 1 130 ? 32.639 -11.918 -14.113 1.00 14.52 ? 114 ILE A CG1 1 ATOM 862 C CG2 . ILE A 1 130 ? 32.589 -11.109 -16.444 1.00 11.37 ? 114 ILE A CG2 1 ATOM 863 C CD1 . ILE A 1 130 ? 33.129 -12.930 -13.140 1.00 9.74 ? 114 ILE A CD1 1 ATOM 864 N N . THR A 1 131 ? 29.820 -13.622 -14.429 1.00 9.08 ? 115 THR A N 1 ATOM 865 C CA . THR A 1 131 ? 28.523 -13.284 -13.872 1.00 9.48 ? 115 THR A CA 1 ATOM 866 C C . THR A 1 131 ? 28.651 -12.915 -12.408 1.00 9.08 ? 115 THR A C 1 ATOM 867 O O . THR A 1 131 ? 29.302 -13.605 -11.652 1.00 9.20 ? 115 THR A O 1 ATOM 868 C CB . THR A 1 131 ? 27.539 -14.456 -14.021 1.00 10.91 ? 115 THR A CB 1 ATOM 869 O OG1 . THR A 1 131 ? 27.264 -14.647 -15.405 1.00 12.57 ? 115 THR A OG1 1 ATOM 870 C CG2 . THR A 1 131 ? 26.206 -14.193 -13.289 1.00 10.79 ? 115 THR A CG2 1 ATOM 871 N N . CYS A 1 132 ? 28.016 -11.812 -12.024 1.00 9.68 ? 116 CYS A N 1 ATOM 872 C CA . CYS A 1 132 ? 28.063 -11.310 -10.665 1.00 11.38 ? 116 CYS A CA 1 ATOM 873 C C . CYS A 1 132 ? 26.653 -11.058 -10.183 1.00 12.07 ? 116 CYS A C 1 ATOM 874 O O . CYS A 1 132 ? 25.841 -10.519 -10.907 1.00 15.41 ? 116 CYS A O 1 ATOM 875 C CB . CYS A 1 132 ? 28.875 -10.008 -10.620 1.00 12.11 ? 116 CYS A CB 1 ATOM 876 S SG . CYS A 1 132 ? 30.663 -10.180 -10.828 1.00 14.13 ? 116 CYS A SG 1 ATOM 877 N N . ALA A 1 133 ? 26.352 -11.460 -8.963 1.00 12.47 ? 117 ALA A N 1 ATOM 878 C CA . ALA A 1 133 ? 25.067 -11.158 -8.373 1.00 13.46 ? 117 ALA A CA 1 ATOM 879 C C . ALA A 1 133 ? 25.220 -10.635 -6.954 1.00 11.27 ? 117 ALA A C 1 ATOM 880 O O . ALA A 1 133 ? 26.140 -10.989 -6.261 1.00 12.76 ? 117 ALA A O 1 ATOM 881 C CB . ALA A 1 133 ? 24.200 -12.390 -8.381 1.00 18.69 ? 117 ALA A CB 1 ATOM 882 N N . LYS A 1 134 ? 24.286 -9.798 -6.528 1.00 12.73 ? 118 LYS A N 1 ATOM 883 C CA . LYS A 1 134 ? 24.299 -9.235 -5.194 1.00 15.46 ? 118 LYS A CA 1 ATOM 884 C C . LYS A 1 134 ? 23.678 -10.227 -4.209 1.00 13.16 ? 118 LYS A C 1 ATOM 885 O O . LYS A 1 134 ? 22.554 -10.675 -4.403 1.00 15.03 ? 118 LYS A O 1 ATOM 886 C CB . LYS A 1 134 ? 23.533 -7.902 -5.190 1.00 17.26 ? 118 LYS A CB 1 ATOM 887 C CG . LYS A 1 134 ? 23.858 -6.942 -4.048 1.00 15.85 ? 118 LYS A CG 1 ATOM 888 C CD . LYS A 1 134 ? 23.017 -5.674 -4.197 1.00 25.22 ? 118 LYS A CD 1 ATOM 889 C CE . LYS A 1 134 ? 23.422 -4.549 -3.266 1.00 30.89 ? 118 LYS A CE 1 ATOM 890 N NZ . LYS A 1 134 ? 22.524 -3.366 -3.446 1.00 39.71 ? 118 LYS A NZ 1 ATOM 891 N N . PHE A 1 135 ? 24.442 -10.569 -3.172 1.00 14.95 ? 119 PHE A N 1 ATOM 892 C CA . PHE A 1 135 ? 24.026 -11.489 -2.116 1.00 13.81 ? 119 PHE A CA 1 ATOM 893 C C . PHE A 1 135 ? 23.483 -10.684 -0.944 1.00 13.45 ? 119 PHE A C 1 ATOM 894 O O . PHE A 1 135 ? 24.103 -9.710 -0.532 1.00 14.97 ? 119 PHE A O 1 ATOM 895 C CB . PHE A 1 135 ? 25.233 -12.319 -1.661 1.00 12.66 ? 119 PHE A CB 1 ATOM 896 C CG . PHE A 1 135 ? 24.939 -13.308 -0.561 1.00 12.58 ? 119 PHE A CG 1 ATOM 897 C CD1 . PHE A 1 135 ? 24.491 -14.587 -0.857 1.00 15.50 ? 119 PHE A CD1 1 ATOM 898 C CD2 . PHE A 1 135 ? 25.151 -12.980 0.775 1.00 14.75 ? 119 PHE A CD2 1 ATOM 899 C CE1 . PHE A 1 135 ? 24.247 -15.496 0.165 1.00 12.37 ? 119 PHE A CE1 1 ATOM 900 C CE2 . PHE A 1 135 ? 24.887 -13.882 1.786 1.00 11.03 ? 119 PHE A CE2 1 ATOM 901 C CZ . PHE A 1 135 ? 24.444 -15.132 1.482 1.00 12.44 ? 119 PHE A CZ 1 ATOM 902 N N . LYS A 1 136 ? 22.317 -11.077 -0.422 1.00 13.88 ? 120 LYS A N 1 ATOM 903 C CA . LYS A 1 136 ? 21.772 -10.473 0.796 1.00 15.16 ? 120 LYS A CA 1 ATOM 904 C C . LYS A 1 136 ? 21.295 -11.554 1.742 1.00 14.33 ? 120 LYS A C 1 ATOM 905 O O . LYS A 1 136 ? 20.603 -12.472 1.320 1.00 14.00 ? 120 LYS A O 1 ATOM 906 C CB . LYS A 1 136 ? 20.588 -9.570 0.477 1.00 17.29 ? 120 LYS A CB 1 ATOM 907 C CG . LYS A 1 136 ? 20.550 -8.301 1.276 1.00 29.40 ? 120 LYS A CG 1 ATOM 908 C CD . LYS A 1 136 ? 21.869 -7.543 1.143 1.00 32.27 ? 120 LYS A CD 1 ATOM 909 C CE . LYS A 1 136 ? 22.330 -7.427 -0.308 1.00 25.16 ? 120 LYS A CE 1 ATOM 910 N NZ . LYS A 1 136 ? 23.739 -6.970 -0.395 1.00 23.25 ? 120 LYS A NZ 1 ATOM 911 N N . CYS A 1 137 ? 21.657 -11.447 3.017 1.00 14.60 ? 121 CYS A N 1 ATOM 912 C CA . CYS A 1 137 ? 21.105 -12.354 4.023 1.00 18.46 ? 121 CYS A CA 1 ATOM 913 C C . CYS A 1 137 ? 19.775 -11.831 4.535 1.00 13.51 ? 121 CYS A C 1 ATOM 914 O O . CYS A 1 137 ? 19.673 -10.682 4.957 1.00 14.47 ? 121 CYS A O 1 ATOM 915 C CB . CYS A 1 137 ? 22.056 -12.562 5.194 1.00 12.48 ? 121 CYS A CB 1 ATOM 916 S SG . CYS A 1 137 ? 21.573 -13.980 6.182 1.00 17.78 ? 121 CYS A SG 1 ATOM 917 N N . VAL A 1 138 ? 18.771 -12.691 4.474 1.00 11.08 ? 122 VAL A N 1 ATOM 918 C CA . VAL A 1 138 ? 17.395 -12.366 4.838 1.00 15.89 ? 122 VAL A CA 1 ATOM 919 C C . VAL A 1 138 ? 17.079 -12.846 6.257 1.00 16.46 ? 122 VAL A C 1 ATOM 920 O O . VAL A 1 138 ? 16.383 -12.180 7.023 1.00 15.86 ? 122 VAL A O 1 ATOM 921 C CB . VAL A 1 138 ? 16.424 -13.061 3.864 1.00 13.63 ? 122 VAL A CB 1 ATOM 922 C CG1 . VAL A 1 138 ? 14.989 -12.904 4.300 1.00 21.92 ? 122 VAL A CG1 1 ATOM 923 C CG2 . VAL A 1 138 ? 16.617 -12.534 2.468 1.00 17.25 ? 122 VAL A CG2 1 ATOM 924 N N . THR A 1 139 ? 17.602 -14.021 6.582 1.00 16.10 ? 123 THR A N 1 ATOM 925 C CA . THR A 1 139 ? 17.413 -14.644 7.874 1.00 18.93 ? 123 THR A CA 1 ATOM 926 C C . THR A 1 139 ? 18.790 -15.139 8.332 1.00 13.27 ? 123 THR A C 1 ATOM 927 O O . THR A 1 139 ? 19.451 -15.890 7.641 1.00 12.17 ? 123 THR A O 1 ATOM 928 C CB . THR A 1 139 ? 16.405 -15.825 7.795 1.00 15.14 ? 123 THR A CB 1 ATOM 929 O OG1 . THR A 1 139 ? 15.228 -15.414 7.099 1.00 18.54 ? 123 THR A OG1 1 ATOM 930 C CG2 . THR A 1 139 ? 16.006 -16.277 9.169 1.00 20.29 ? 123 THR A CG2 1 ATOM 931 N N . LYS A 1 140 ? 19.225 -14.687 9.496 1.00 16.78 ? 124 LYS A N 1 ATOM 932 C CA . LYS A 1 140 ? 20.507 -15.097 10.035 1.00 15.09 ? 124 LYS A CA 1 ATOM 933 C C . LYS A 1 140 ? 20.333 -15.696 11.430 1.00 15.39 ? 124 LYS A C 1 ATOM 934 O O . LYS A 1 140 ? 19.285 -15.551 12.059 1.00 15.95 ? 124 LYS A O 1 ATOM 935 C CB . LYS A 1 140 ? 21.482 -13.909 10.053 1.00 14.89 ? 124 LYS A CB 1 ATOM 936 C CG . LYS A 1 140 ? 20.843 -12.560 10.419 1.00 23.66 ? 124 LYS A CG 1 ATOM 937 C CD . LYS A 1 140 ? 21.872 -11.471 10.810 1.00 33.37 ? 124 LYS A CD 1 ATOM 938 C CE . LYS A 1 140 ? 21.202 -10.176 11.322 1.00 34.26 ? 124 LYS A CE 1 ATOM 939 N NZ . LYS A 1 140 ? 22.040 -9.386 12.293 1.00 31.87 ? 124 LYS A NZ 1 ATOM 940 N N . LEU A 1 141 ? 21.358 -16.396 11.889 1.00 12.66 ? 125 LEU A N 1 ATOM 941 C CA . LEU A 1 141 ? 21.445 -16.792 13.273 1.00 15.93 ? 125 LEU A CA 1 ATOM 942 C C . LEU A 1 141 ? 22.755 -16.246 13.838 1.00 13.41 ? 125 LEU A C 1 ATOM 943 O O . LEU A 1 141 ? 23.651 -15.843 13.075 1.00 11.90 ? 125 LEU A O 1 ATOM 944 C CB . LEU A 1 141 ? 21.326 -18.317 13.406 1.00 15.17 ? 125 LEU A CB 1 ATOM 945 C CG . LEU A 1 141 ? 22.437 -19.218 12.881 1.00 13.96 ? 125 LEU A CG 1 ATOM 946 C CD1 . LEU A 1 141 ? 23.628 -19.191 13.795 1.00 10.03 ? 125 LEU A CD1 1 ATOM 947 C CD2 . LEU A 1 141 ? 21.937 -20.644 12.744 1.00 16.76 ? 125 LEU A CD2 1 ATOM 948 N N . GLU A 1 142 ? 22.858 -16.250 15.169 1.00 14.46 ? 126 GLU A N 1 ATOM 949 C CA . GLU A 1 142 ? 24.008 -15.718 15.890 1.00 9.76 ? 126 GLU A CA 1 ATOM 950 C C . GLU A 1 142 ? 24.522 -16.691 16.953 1.00 10.67 ? 126 GLU A C 1 ATOM 951 O O . GLU A 1 142 ? 23.748 -17.249 17.711 1.00 12.63 ? 126 GLU A O 1 ATOM 952 C CB . GLU A 1 142 ? 23.606 -14.414 16.575 1.00 14.13 ? 126 GLU A CB 1 ATOM 953 C CG . GLU A 1 142 ? 23.066 -13.362 15.614 1.00 16.38 ? 126 GLU A CG 1 ATOM 954 C CD . GLU A 1 142 ? 23.131 -11.962 16.185 1.00 24.23 ? 126 GLU A CD 1 ATOM 955 O OE1 . GLU A 1 142 ? 23.341 -11.003 15.413 1.00 27.67 ? 126 GLU A OE1 1 ATOM 956 O OE2 . GLU A 1 142 ? 22.962 -11.821 17.413 1.00 32.29 ? 126 GLU A OE2 1 ATOM 957 N N . GLY A 1 143 ? 25.827 -16.919 17.002 1.00 10.86 ? 127 GLY A N 1 ATOM 958 C CA . GLY A 1 143 ? 26.406 -17.671 18.105 1.00 6.22 ? 127 GLY A CA 1 ATOM 959 C C . GLY A 1 143 ? 27.120 -16.722 19.031 1.00 6.38 ? 127 GLY A C 1 ATOM 960 O O . GLY A 1 143 ? 27.934 -15.941 18.593 1.00 9.89 ? 127 GLY A O 1 ATOM 961 N N . LYS A 1 144 ? 26.817 -16.798 20.320 1.00 9.11 ? 128 LYS A N 1 ATOM 962 C CA . LYS A 1 144 ? 27.285 -15.818 21.288 1.00 10.24 ? 128 LYS A CA 1 ATOM 963 C C . LYS A 1 144 ? 28.063 -16.460 22.426 1.00 7.08 ? 128 LYS A C 1 ATOM 964 O O . LYS A 1 144 ? 27.677 -17.505 22.930 1.00 7.96 ? 128 LYS A O 1 ATOM 965 C CB . LYS A 1 144 ? 26.096 -15.039 21.849 1.00 10.00 ? 128 LYS A CB 1 ATOM 966 C CG . LYS A 1 144 ? 25.310 -14.279 20.804 1.00 9.56 ? 128 LYS A CG 1 ATOM 967 C CD . LYS A 1 144 ? 23.919 -13.987 21.293 1.00 13.02 ? 128 LYS A CD 1 ATOM 968 C CE . LYS A 1 144 ? 23.053 -15.252 21.213 1.00 17.37 ? 128 LYS A CE 1 ATOM 969 N NZ . LYS A 1 144 ? 21.950 -15.305 22.241 1.00 21.33 ? 128 LYS A NZ 1 ATOM 970 N N . ILE A 1 145 ? 29.163 -15.833 22.827 1.00 7.85 ? 129 ILE A N 1 ATOM 971 C CA . ILE A 1 145 ? 29.985 -16.387 23.896 1.00 6.67 ? 129 ILE A CA 1 ATOM 972 C C . ILE A 1 145 ? 29.702 -15.748 25.245 1.00 9.07 ? 129 ILE A C 1 ATOM 973 O O . ILE A 1 145 ? 29.540 -14.530 25.352 1.00 10.87 ? 129 ILE A O 1 ATOM 974 C CB . ILE A 1 145 ? 31.487 -16.269 23.580 1.00 11.09 ? 129 ILE A CB 1 ATOM 975 C CG1 . ILE A 1 145 ? 31.836 -14.844 23.155 1.00 7.99 ? 129 ILE A CG1 1 ATOM 976 C CG2 . ILE A 1 145 ? 31.870 -17.245 22.476 1.00 9.31 ? 129 ILE A CG2 1 ATOM 977 C CD1 . ILE A 1 145 ? 33.250 -14.509 23.335 1.00 14.19 ? 129 ILE A CD1 1 ATOM 978 N N . VAL A 1 146 ? 29.619 -16.574 26.280 1.00 8.75 ? 130 VAL A N 1 ATOM 979 C CA . VAL A 1 146 ? 29.409 -16.065 27.631 1.00 7.49 ? 130 VAL A CA 1 ATOM 980 C C . VAL A 1 146 ? 30.765 -15.903 28.266 1.00 6.40 ? 130 VAL A C 1 ATOM 981 O O . VAL A 1 146 ? 31.528 -16.843 28.362 1.00 8.52 ? 130 VAL A O 1 ATOM 982 C CB . VAL A 1 146 ? 28.532 -16.993 28.501 1.00 6.56 ? 130 VAL A CB 1 ATOM 983 C CG1 . VAL A 1 146 ? 28.316 -16.385 29.884 1.00 7.20 ? 130 VAL A CG1 1 ATOM 984 C CG2 . VAL A 1 146 ? 27.187 -17.290 27.818 1.00 6.12 ? 130 VAL A CG2 1 ATOM 985 N N . GLN A 1 147 ? 31.073 -14.675 28.645 1.00 6.15 ? 131 GLN A N 1 ATOM 986 C CA . GLN A 1 147 ? 32.299 -14.349 29.339 1.00 7.32 ? 131 GLN A CA 1 ATOM 987 C C . GLN A 1 147 ? 31.972 -14.088 30.814 1.00 5.52 ? 131 GLN A C 1 ATOM 988 O O . GLN A 1 147 ? 30.822 -14.104 31.184 1.00 5.53 ? 131 GLN A O 1 ATOM 989 C CB . GLN A 1 147 ? 32.934 -13.117 28.699 1.00 7.00 ? 131 GLN A CB 1 ATOM 990 C CG . GLN A 1 147 ? 33.368 -13.296 27.242 1.00 9.10 ? 131 GLN A CG 1 ATOM 991 C CD . GLN A 1 147 ? 33.859 -11.995 26.649 1.00 9.03 ? 131 GLN A CD 1 ATOM 992 O OE1 . GLN A 1 147 ? 34.962 -11.542 26.949 1.00 10.82 ? 131 GLN A OE1 1 ATOM 993 N NE2 . GLN A 1 147 ? 33.024 -11.363 25.836 1.00 10.51 ? 131 GLN A NE2 1 ATOM 994 N N . TYR A 1 148 ? 32.976 -13.840 31.647 1.00 6.41 ? 132 TYR A N 1 ATOM 995 C CA . TYR A 1 148 ? 32.740 -13.550 33.069 1.00 6.58 ? 132 TYR A CA 1 ATOM 996 C C . TYR A 1 148 ? 31.850 -12.331 33.303 1.00 6.92 ? 132 TYR A C 1 ATOM 997 O O . TYR A 1 148 ? 31.079 -12.321 34.239 1.00 8.37 ? 132 TYR A O 1 ATOM 998 C CB . TYR A 1 148 ? 34.059 -13.276 33.783 1.00 10.19 ? 132 TYR A CB 1 ATOM 999 C CG . TYR A 1 148 ? 35.016 -14.448 33.917 1.00 10.25 ? 132 TYR A CG 1 ATOM 1000 C CD1 . TYR A 1 148 ? 34.572 -15.683 34.327 1.00 12.65 ? 132 TYR A CD1 1 ATOM 1001 C CD2 . TYR A 1 148 ? 36.373 -14.289 33.658 1.00 11.36 ? 132 TYR A CD2 1 ATOM 1002 C CE1 . TYR A 1 148 ? 35.445 -16.745 34.472 1.00 17.11 ? 132 TYR A CE1 1 ATOM 1003 C CE2 . TYR A 1 148 ? 37.262 -15.340 33.785 1.00 14.97 ? 132 TYR A CE2 1 ATOM 1004 C CZ . TYR A 1 148 ? 36.790 -16.575 34.193 1.00 19.77 ? 132 TYR A CZ 1 ATOM 1005 O OH . TYR A 1 148 ? 37.655 -17.640 34.342 1.00 23.02 ? 132 TYR A OH 1 ATOM 1006 N N . GLU A 1 149 ? 32.000 -11.294 32.479 1.00 7.37 ? 133 GLU A N 1 ATOM 1007 C CA . GLU A 1 149 ? 31.256 -10.032 32.613 1.00 8.01 ? 133 GLU A CA 1 ATOM 1008 C C . GLU A 1 149 ? 29.781 -10.168 32.239 1.00 7.27 ? 133 GLU A C 1 ATOM 1009 O O . GLU A 1 149 ? 29.003 -9.254 32.403 1.00 9.23 ? 133 GLU A O 1 ATOM 1010 C CB . GLU A 1 149 ? 31.877 -8.925 31.734 1.00 6.59 ? 133 GLU A CB 1 ATOM 1011 C CG . GLU A 1 149 ? 31.603 -9.137 30.230 1.00 9.93 ? 133 GLU A CG 1 ATOM 1012 C CD . GLU A 1 149 ? 32.688 -8.591 29.315 1.00 14.66 ? 133 GLU A CD 1 ATOM 1013 O OE1 . GLU A 1 149 ? 32.357 -7.834 28.365 1.00 14.18 ? 133 GLU A OE1 1 ATOM 1014 O OE2 . GLU A 1 149 ? 33.872 -8.937 29.521 1.00 17.75 ? 133 GLU A OE2 1 ATOM 1015 N N . ASN A 1 150 ? 29.393 -11.319 31.728 1.00 8.33 ? 134 ASN A N 1 ATOM 1016 C CA . ASN A 1 150 ? 28.012 -11.529 31.327 1.00 5.19 ? 134 ASN A CA 1 ATOM 1017 C C . ASN A 1 150 ? 27.189 -12.310 32.341 1.00 6.19 ? 134 ASN A C 1 ATOM 1018 O O . ASN A 1 150 ? 25.995 -12.411 32.193 1.00 10.68 ? 134 ASN A O 1 ATOM 1019 C CB . ASN A 1 150 ? 27.983 -12.248 29.985 1.00 6.40 ? 134 ASN A CB 1 ATOM 1020 C CG . ASN A 1 150 ? 28.837 -11.558 28.950 1.00 6.24 ? 134 ASN A CG 1 ATOM 1021 O OD1 . ASN A 1 150 ? 29.881 -12.064 28.545 1.00 6.90 ? 134 ASN A OD1 1 ATOM 1022 N ND2 . ASN A 1 150 ? 28.405 -10.378 28.536 1.00 6.10 ? 134 ASN A ND2 1 ATOM 1023 N N . LEU A 1 151 ? 27.811 -12.841 33.381 1.00 7.27 ? 135 LEU A N 1 ATOM 1024 C CA . LEU A 1 151 ? 27.116 -13.687 34.333 1.00 8.51 ? 135 LEU A CA 1 ATOM 1025 C C . LEU A 1 151 ? 26.830 -12.954 35.640 1.00 8.86 ? 135 LEU A C 1 ATOM 1026 O O . LEU A 1 151 ? 27.689 -12.246 36.153 1.00 8.78 ? 135 LEU A O 1 ATOM 1027 C CB . LEU A 1 151 ? 27.955 -14.928 34.615 1.00 9.11 ? 135 LEU A CB 1 ATOM 1028 C CG . LEU A 1 151 ? 27.256 -16.283 34.684 1.00 11.26 ? 135 LEU A CG 1 ATOM 1029 C CD1 . LEU A 1 151 ? 28.091 -17.143 35.568 1.00 11.41 ? 135 LEU A CD1 1 ATOM 1030 C CD2 . LEU A 1 151 ? 25.814 -16.280 35.178 1.00 9.69 ? 135 LEU A CD2 1 ATOM 1031 N N . LYS A 1 152 ? 25.624 -13.147 36.173 1.00 9.20 ? 136 LYS A N 1 ATOM 1032 C CA . LYS A 1 152 ? 25.164 -12.462 37.370 1.00 11.08 ? 136 LYS A CA 1 ATOM 1033 C C . LYS A 1 152 ? 24.218 -13.349 38.173 1.00 8.43 ? 136 LYS A C 1 ATOM 1034 O O . LYS A 1 152 ? 23.400 -14.063 37.603 1.00 8.20 ? 136 LYS A O 1 ATOM 1035 C CB . LYS A 1 152 ? 24.439 -11.180 36.968 1.00 15.06 ? 136 LYS A CB 1 ATOM 1036 C CG . LYS A 1 152 ? 23.777 -10.456 38.088 1.00 14.40 ? 136 LYS A CG 1 ATOM 1037 C CD . LYS A 1 152 ? 23.210 -9.140 37.599 1.00 17.22 ? 136 LYS A CD 1 ATOM 1038 C CE . LYS A 1 152 ? 21.947 -9.315 36.782 1.00 20.28 ? 136 LYS A CE 1 ATOM 1039 N NZ . LYS A 1 152 ? 21.307 -8.001 36.468 1.00 23.94 ? 136 LYS A NZ 1 ATOM 1040 N N . TYR A 1 153 ? 24.355 -13.291 39.494 1.00 9.25 ? 137 TYR A N 1 ATOM 1041 C CA . TYR A 1 153 ? 23.523 -14.040 40.424 1.00 7.93 ? 137 TYR A CA 1 ATOM 1042 C C . TYR A 1 153 ? 22.926 -13.101 41.442 1.00 8.23 ? 137 TYR A C 1 ATOM 1043 O O . TYR A 1 153 ? 23.607 -12.235 41.959 1.00 10.31 ? 137 TYR A O 1 ATOM 1044 C CB . TYR A 1 153 ? 24.355 -15.043 41.210 1.00 10.48 ? 137 TYR A CB 1 ATOM 1045 C CG . TYR A 1 153 ? 25.038 -16.081 40.391 1.00 9.39 ? 137 TYR A CG 1 ATOM 1046 C CD1 . TYR A 1 153 ? 26.209 -15.802 39.721 1.00 9.50 ? 137 TYR A CD1 1 ATOM 1047 C CD2 . TYR A 1 153 ? 24.521 -17.357 40.304 1.00 10.42 ? 137 TYR A CD2 1 ATOM 1048 C CE1 . TYR A 1 153 ? 26.838 -16.768 38.964 1.00 11.51 ? 137 TYR A CE1 1 ATOM 1049 C CE2 . TYR A 1 153 ? 25.142 -18.326 39.569 1.00 9.42 ? 137 TYR A CE2 1 ATOM 1050 C CZ . TYR A 1 153 ? 26.293 -18.027 38.894 1.00 9.34 ? 137 TYR A CZ 1 ATOM 1051 O OH . TYR A 1 153 ? 26.910 -19.000 38.165 1.00 12.45 ? 137 TYR A OH 1 ATOM 1052 N N . SER A 1 154 ? 21.655 -13.288 41.762 1.00 11.10 ? 138 SER A N 1 ATOM 1053 C CA . SER A 1 154 ? 21.031 -12.512 42.819 1.00 10.62 ? 138 SER A CA 1 ATOM 1054 C C . SER A 1 154 ? 20.804 -13.424 44.005 1.00 9.88 ? 138 SER A C 1 ATOM 1055 O O . SER A 1 154 ? 20.123 -14.436 43.893 1.00 11.21 ? 138 SER A O 1 ATOM 1056 C CB . SER A 1 154 ? 19.711 -11.919 42.368 1.00 7.13 ? 138 SER A CB 1 ATOM 1057 O OG . SER A 1 154 ? 19.792 -11.438 41.062 1.00 12.96 ? 138 SER A OG 1 ATOM 1058 N N . VAL A 1 155 ? 21.384 -13.067 45.142 1.00 10.05 ? 139 VAL A N 1 ATOM 1059 C CA . VAL A 1 155 ? 21.269 -13.871 46.335 1.00 12.58 ? 139 VAL A CA 1 ATOM 1060 C C . VAL A 1 155 ? 20.552 -13.088 47.420 1.00 12.67 ? 139 VAL A C 1 ATOM 1061 O O . VAL A 1 155 ? 20.980 -11.995 47.801 1.00 11.08 ? 139 VAL A O 1 ATOM 1062 C CB . VAL A 1 155 ? 22.645 -14.294 46.853 1.00 8.61 ? 139 VAL A CB 1 ATOM 1063 C CG1 . VAL A 1 155 ? 22.488 -15.075 48.121 1.00 12.45 ? 139 VAL A CG1 1 ATOM 1064 C CG2 . VAL A 1 155 ? 23.358 -15.128 45.816 1.00 12.06 ? 139 VAL A CG2 1 ATOM 1065 N N . ILE A 1 156 ? 19.456 -13.637 47.923 1.00 11.66 ? 140 ILE A N 1 ATOM 1066 C CA . ILE A 1 156 ? 18.741 -12.944 48.982 1.00 13.06 ? 140 ILE A CA 1 ATOM 1067 C C . ILE A 1 156 ? 19.080 -13.512 50.356 1.00 12.32 ? 140 ILE A C 1 ATOM 1068 O O . ILE A 1 156 ? 19.033 -14.712 50.569 1.00 11.53 ? 140 ILE A O 1 ATOM 1069 C CB . ILE A 1 156 ? 17.238 -12.975 48.773 1.00 14.12 ? 140 ILE A CB 1 ATOM 1070 C CG1 . ILE A 1 156 ? 16.572 -12.023 49.773 1.00 17.69 ? 140 ILE A CG1 1 ATOM 1071 C CG2 . ILE A 1 156 ? 16.717 -14.395 48.907 1.00 16.86 ? 140 ILE A CG2 1 ATOM 1072 C CD1 . ILE A 1 156 ? 15.168 -11.639 49.416 1.00 16.63 ? 140 ILE A CD1 1 ATOM 1073 N N . VAL A 1 157 ? 19.422 -12.620 51.276 1.00 14.43 ? 141 VAL A N 1 ATOM 1074 C CA . VAL A 1 157 ? 19.756 -12.977 52.652 1.00 16.55 ? 141 VAL A CA 1 ATOM 1075 C C . VAL A 1 157 ? 18.701 -12.384 53.600 1.00 17.07 ? 141 VAL A C 1 ATOM 1076 O O . VAL A 1 157 ? 18.434 -11.185 53.566 1.00 18.36 ? 141 VAL A O 1 ATOM 1077 C CB . VAL A 1 157 ? 21.153 -12.439 53.024 1.00 13.30 ? 141 VAL A CB 1 ATOM 1078 C CG1 . VAL A 1 157 ? 21.544 -12.845 54.439 1.00 15.23 ? 141 VAL A CG1 1 ATOM 1079 C CG2 . VAL A 1 157 ? 22.185 -12.883 51.989 1.00 14.49 ? 141 VAL A CG2 1 ATOM 1080 N N . THR A 1 158 ? 18.094 -13.225 54.434 1.00 17.78 ? 142 THR A N 1 ATOM 1081 C CA . THR A 1 158 ? 16.970 -12.796 55.277 1.00 20.73 ? 142 THR A CA 1 ATOM 1082 C C . THR A 1 158 ? 17.199 -13.062 56.771 1.00 15.60 ? 142 THR A C 1 ATOM 1083 O O . THR A 1 158 ? 17.425 -14.196 57.169 1.00 17.83 ? 142 THR A O 1 ATOM 1084 C CB . THR A 1 158 ? 15.646 -13.506 54.857 1.00 21.60 ? 142 THR A CB 1 ATOM 1085 O OG1 . THR A 1 158 ? 15.663 -13.808 53.457 1.00 24.79 ? 142 THR A OG1 1 ATOM 1086 C CG2 . THR A 1 158 ? 14.434 -12.637 55.161 1.00 19.73 ? 142 THR A CG2 1 ATOM 1087 N N . VAL A 1 159 ? 17.131 -12.014 57.592 1.00 21.58 ? 143 VAL A N 1 ATOM 1088 C CA . VAL A 1 159 ? 17.091 -12.176 59.056 1.00 26.16 ? 143 VAL A CA 1 ATOM 1089 C C . VAL A 1 159 ? 15.647 -12.184 59.555 1.00 20.56 ? 143 VAL A C 1 ATOM 1090 O O . VAL A 1 159 ? 14.872 -11.276 59.282 1.00 22.60 ? 143 VAL A O 1 ATOM 1091 C CB . VAL A 1 159 ? 17.862 -11.070 59.815 1.00 20.35 ? 143 VAL A CB 1 ATOM 1092 C CG1 . VAL A 1 159 ? 17.872 -11.370 61.296 1.00 23.57 ? 143 VAL A CG1 1 ATOM 1093 C CG2 . VAL A 1 159 ? 19.284 -10.939 59.298 1.00 23.27 ? 143 VAL A CG2 1 ATOM 1094 N N . HIS A 1 160 ? 15.310 -13.225 60.299 1.00 20.51 ? 144 HIS A N 1 ATOM 1095 C CA . HIS A 1 160 ? 13.942 -13.487 60.709 1.00 24.44 ? 144 HIS A CA 1 ATOM 1096 C C . HIS A 1 160 ? 13.506 -12.757 61.980 1.00 31.52 ? 144 HIS A C 1 ATOM 1097 O O . HIS A 1 160 ? 13.090 -13.379 62.957 1.00 31.28 ? 144 HIS A O 1 ATOM 1098 C CB . HIS A 1 160 ? 13.768 -14.986 60.926 1.00 23.62 ? 144 HIS A CB 1 ATOM 1099 C CG . HIS A 1 160 ? 13.041 -15.647 59.816 1.00 21.37 ? 144 HIS A CG 1 ATOM 1100 N ND1 . HIS A 1 160 ? 12.564 -15.002 58.708 1.00 26.29 ? 144 HIS A ND1 1 ATOM 1101 C CD2 . HIS A 1 160 ? 12.690 -16.964 59.664 1.00 28.82 ? 144 HIS A CD2 1 ATOM 1102 C CE1 . HIS A 1 160 ? 11.974 -15.835 57.924 1.00 32.92 ? 144 HIS A CE1 1 ATOM 1103 N NE2 . HIS A 1 160 ? 12.018 -17.049 58.455 1.00 41.83 ? 144 HIS A NE2 1 ATOM 1104 N N . THR A 1 161 ? 13.604 -11.434 61.957 1.00 34.89 ? 145 THR A N 1 ATOM 1105 C CA . THR A 1 161 ? 12.894 -10.613 62.913 1.00 33.29 ? 145 THR A CA 1 ATOM 1106 C C . THR A 1 161 ? 11.408 -10.662 62.553 1.00 41.55 ? 145 THR A C 1 ATOM 1107 O O . THR A 1 161 ? 10.564 -10.235 63.335 1.00 43.62 ? 145 THR A O 1 ATOM 1108 C CB . THR A 1 161 ? 13.403 -9.177 62.887 1.00 32.71 ? 145 THR A CB 1 ATOM 1109 O OG1 . THR A 1 161 ? 13.153 -8.604 61.599 1.00 38.86 ? 145 THR A OG1 1 ATOM 1110 C CG2 . THR A 1 161 ? 14.898 -9.142 63.185 1.00 28.43 ? 145 THR A CG2 1 ATOM 1111 N N . GLY A 1 162 ? 11.107 -11.185 61.362 1.00 40.26 ? 146 GLY A N 1 ATOM 1112 C CA . GLY A 1 162 ? 9.741 -11.416 60.924 1.00 45.01 ? 146 GLY A CA 1 ATOM 1113 C C . GLY A 1 162 ? 8.874 -10.174 60.972 1.00 47.15 ? 146 GLY A C 1 ATOM 1114 O O . GLY A 1 162 ? 8.976 -9.358 61.887 1.00 38.71 ? 146 GLY A O 1 ATOM 1115 N N . GLY A 1 175 ? 14.579 -8.470 53.746 1.00 26.91 ? 159 GLY A N 1 ATOM 1116 C CA . GLY A 1 175 ? 15.623 -9.218 53.072 1.00 21.27 ? 159 GLY A CA 1 ATOM 1117 C C . GLY A 1 175 ? 16.514 -8.356 52.196 1.00 21.04 ? 159 GLY A C 1 ATOM 1118 O O . GLY A 1 175 ? 16.058 -7.414 51.552 1.00 26.77 ? 159 GLY A O 1 ATOM 1119 N N . THR A 1 176 ? 17.796 -8.695 52.157 1.00 18.33 ? 160 THR A N 1 ATOM 1120 C CA . THR A 1 176 ? 18.752 -7.966 51.347 1.00 18.18 ? 160 THR A CA 1 ATOM 1121 C C . THR A 1 176 ? 19.191 -8.815 50.163 1.00 15.95 ? 160 THR A C 1 ATOM 1122 O O . THR A 1 176 ? 19.603 -9.955 50.335 1.00 15.53 ? 160 THR A O 1 ATOM 1123 C CB . THR A 1 176 ? 19.978 -7.587 52.185 1.00 21.23 ? 160 THR A CB 1 ATOM 1124 O OG1 . THR A 1 176 ? 19.635 -6.539 53.098 1.00 27.08 ? 160 THR A OG1 1 ATOM 1125 C CG2 . THR A 1 176 ? 21.092 -7.114 51.297 1.00 20.52 ? 160 THR A CG2 1 ATOM 1126 N N . ILE A 1 177 ? 19.104 -8.251 48.964 1.00 14.24 ? 161 ILE A N 1 ATOM 1127 C CA . ILE A 1 177 ? 19.469 -8.958 47.740 1.00 15.00 ? 161 ILE A CA 1 ATOM 1128 C C . ILE A 1 177 ? 20.884 -8.572 47.329 1.00 13.64 ? 161 ILE A C 1 ATOM 1129 O O . ILE A 1 177 ? 21.128 -7.453 46.918 1.00 18.13 ? 161 ILE A O 1 ATOM 1130 C CB . ILE A 1 177 ? 18.526 -8.620 46.589 1.00 12.99 ? 161 ILE A CB 1 ATOM 1131 C CG1 . ILE A 1 177 ? 17.080 -8.976 46.941 1.00 17.75 ? 161 ILE A CG1 1 ATOM 1132 C CG2 . ILE A 1 177 ? 18.913 -9.366 45.340 1.00 14.74 ? 161 ILE A CG2 1 ATOM 1133 C CD1 . ILE A 1 177 ? 16.419 -8.052 47.958 1.00 26.79 ? 161 ILE A CD1 1 ATOM 1134 N N . ALA A 1 178 ? 21.808 -9.516 47.465 1.00 12.70 ? 162 ALA A N 1 ATOM 1135 C CA . ALA A 1 178 ? 23.197 -9.364 47.050 1.00 11.78 ? 162 ALA A CA 1 ATOM 1136 C C . ALA A 1 178 ? 23.377 -9.675 45.566 1.00 10.92 ? 162 ALA A C 1 ATOM 1137 O O . ALA A 1 178 ? 22.803 -10.619 45.054 1.00 10.35 ? 162 ALA A O 1 ATOM 1138 C CB . ALA A 1 178 ? 24.047 -10.300 47.855 1.00 11.83 ? 162 ALA A CB 1 ATOM 1139 N N . THR A 1 179 ? 24.179 -8.887 44.866 1.00 11.83 ? 163 THR A N 1 ATOM 1140 C CA . THR A 1 179 ? 24.531 -9.223 43.494 1.00 11.58 ? 163 THR A CA 1 ATOM 1141 C C . THR A 1 179 ? 25.920 -9.844 43.483 1.00 9.46 ? 163 THR A C 1 ATOM 1142 O O . THR A 1 179 ? 26.854 -9.295 44.051 1.00 10.94 ? 163 THR A O 1 ATOM 1143 C CB . THR A 1 179 ? 24.440 -7.997 42.559 1.00 11.00 ? 163 THR A CB 1 ATOM 1144 O OG1 . THR A 1 179 ? 23.069 -7.595 42.428 1.00 13.34 ? 163 THR A OG1 1 ATOM 1145 C CG2 . THR A 1 179 ? 24.993 -8.318 41.186 1.00 8.71 ? 163 THR A CG2 1 ATOM 1146 N N . ILE A 1 180 ? 26.036 -11.010 42.859 1.00 8.60 ? 164 ILE A N 1 ATOM 1147 C CA . ILE A 1 180 ? 27.302 -11.738 42.810 1.00 10.33 ? 164 ILE A CA 1 ATOM 1148 C C . ILE A 1 180 ? 27.682 -11.972 41.355 1.00 6.00 ? 164 ILE A C 1 ATOM 1149 O O . ILE A 1 180 ? 26.853 -12.427 40.585 1.00 7.36 ? 164 ILE A O 1 ATOM 1150 C CB . ILE A 1 180 ? 27.164 -13.123 43.493 1.00 8.13 ? 164 ILE A CB 1 ATOM 1151 C CG1 . ILE A 1 180 ? 26.881 -12.997 44.993 1.00 9.07 ? 164 ILE A CG1 1 ATOM 1152 C CG2 . ILE A 1 180 ? 28.373 -13.980 43.222 1.00 8.26 ? 164 ILE A CG2 1 ATOM 1153 C CD1 . ILE A 1 180 ? 27.826 -12.131 45.753 1.00 13.41 ? 164 ILE A CD1 1 ATOM 1154 N N . THR A 1 181 ? 28.921 -11.667 40.979 1.00 7.05 ? 165 THR A N 1 ATOM 1155 C CA . THR A 1 181 ? 29.411 -11.960 39.628 1.00 7.11 ? 165 THR A CA 1 ATOM 1156 C C . THR A 1 181 ? 30.762 -12.628 39.712 1.00 6.95 ? 165 THR A C 1 ATOM 1157 O O . THR A 1 181 ? 31.427 -12.514 40.717 1.00 6.55 ? 165 THR A O 1 ATOM 1158 C CB . THR A 1 181 ? 29.597 -10.711 38.782 1.00 6.97 ? 165 THR A CB 1 ATOM 1159 O OG1 . THR A 1 181 ? 30.528 -9.833 39.422 1.00 9.49 ? 165 THR A OG1 1 ATOM 1160 C CG2 . THR A 1 181 ? 28.281 -9.985 38.566 1.00 8.91 ? 165 THR A CG2 1 ATOM 1161 N N . PRO A 1 182 ? 31.181 -13.325 38.642 1.00 8.09 ? 166 PRO A N 1 ATOM 1162 C CA . PRO A 1 182 ? 32.515 -13.950 38.636 1.00 11.07 ? 166 PRO A CA 1 ATOM 1163 C C . PRO A 1 182 ? 33.687 -13.010 39.053 1.00 9.40 ? 166 PRO A C 1 ATOM 1164 O O . PRO A 1 182 ? 34.497 -13.400 39.885 1.00 10.01 ? 166 PRO A O 1 ATOM 1165 C CB . PRO A 1 182 ? 32.636 -14.460 37.193 1.00 8.65 ? 166 PRO A CB 1 ATOM 1166 C CG . PRO A 1 182 ? 31.227 -14.820 36.823 1.00 8.14 ? 166 PRO A CG 1 ATOM 1167 C CD . PRO A 1 182 ? 30.361 -13.777 37.499 1.00 8.40 ? 166 PRO A CD 1 ATOM 1168 N N . GLN A 1 183 ? 33.749 -11.799 38.508 1.00 7.40 ? 167 GLN A N 1 ATOM 1169 C CA . GLN A 1 183 ? 34.765 -10.815 38.865 1.00 8.47 ? 167 GLN A CA 1 ATOM 1170 C C . GLN A 1 183 ? 34.517 -10.088 40.192 1.00 8.33 ? 167 GLN A C 1 ATOM 1171 O O . GLN A 1 183 ? 35.436 -9.575 40.785 1.00 8.43 ? 167 GLN A O 1 ATOM 1172 C CB . GLN A 1 183 ? 34.856 -9.783 37.760 1.00 7.59 ? 167 GLN A CB 1 ATOM 1173 C CG . GLN A 1 183 ? 35.017 -10.376 36.388 1.00 7.71 ? 167 GLN A CG 1 ATOM 1174 C CD . GLN A 1 183 ? 35.247 -9.324 35.341 1.00 7.96 ? 167 GLN A CD 1 ATOM 1175 O OE1 . GLN A 1 183 ? 36.335 -8.799 35.242 1.00 10.72 ? 167 GLN A OE1 1 ATOM 1176 N NE2 . GLN A 1 183 ? 34.229 -9.009 34.562 1.00 7.40 ? 167 GLN A NE2 1 ATOM 1177 N N . ALA A 1 184 ? 33.277 -10.033 40.650 1.00 10.97 ? 168 ALA A N 1 ATOM 1178 C CA . ALA A 1 184 ? 32.945 -9.428 41.936 1.00 11.35 ? 168 ALA A CA 1 ATOM 1179 C C . ALA A 1 184 ? 32.213 -10.480 42.767 1.00 7.95 ? 168 ALA A C 1 ATOM 1180 O O . ALA A 1 184 ? 31.006 -10.433 42.948 1.00 7.78 ? 168 ALA A O 1 ATOM 1181 C CB . ALA A 1 184 ? 32.089 -8.178 41.738 1.00 9.20 ? 168 ALA A CB 1 ATOM 1182 N N . PRO A 1 185 ? 32.961 -11.466 43.248 1.00 9.16 ? 169 PRO A N 1 ATOM 1183 C CA . PRO A 1 185 ? 32.351 -12.599 43.944 1.00 14.79 ? 169 PRO A CA 1 ATOM 1184 C C . PRO A 1 185 ? 31.932 -12.284 45.368 1.00 12.39 ? 169 PRO A C 1 ATOM 1185 O O . PRO A 1 185 ? 31.238 -13.081 45.974 1.00 11.42 ? 169 PRO A O 1 ATOM 1186 C CB . PRO A 1 185 ? 33.458 -13.656 43.933 1.00 12.28 ? 169 PRO A CB 1 ATOM 1187 C CG . PRO A 1 185 ? 34.712 -12.906 43.786 1.00 14.17 ? 169 PRO A CG 1 ATOM 1188 C CD . PRO A 1 185 ? 34.373 -11.717 42.930 1.00 11.88 ? 169 PRO A CD 1 ATOM 1189 N N . THR A 1 186 ? 32.330 -11.126 45.868 1.00 12.68 ? 170 THR A N 1 ATOM 1190 C CA . THR A 1 186 ? 32.113 -10.776 47.259 1.00 14.49 ? 170 THR A CA 1 ATOM 1191 C C . THR A 1 186 ? 31.085 -9.671 47.422 1.00 15.83 ? 170 THR A C 1 ATOM 1192 O O . THR A 1 186 ? 31.018 -8.743 46.614 1.00 14.82 ? 170 THR A O 1 ATOM 1193 C CB . THR A 1 186 ? 33.416 -10.329 47.918 1.00 15.16 ? 170 THR A CB 1 ATOM 1194 O OG1 . THR A 1 186 ? 34.292 -11.452 48.007 1.00 17.27 ? 170 THR A OG1 1 ATOM 1195 C CG2 . THR A 1 186 ? 33.157 -9.786 49.297 1.00 19.32 ? 170 THR A CG2 1 ATOM 1196 N N . SER A 1 187 ? 30.288 -9.798 48.478 1.00 12.83 ? 171 SER A N 1 ATOM 1197 C CA . SER A 1 187 ? 29.321 -8.791 48.856 1.00 12.86 ? 171 SER A CA 1 ATOM 1198 C C . SER A 1 187 ? 29.289 -8.689 50.376 1.00 13.18 ? 171 SER A C 1 ATOM 1199 O O . SER A 1 187 ? 28.943 -9.656 51.047 1.00 11.14 ? 171 SER A O 1 ATOM 1200 C CB . SER A 1 187 ? 27.952 -9.160 48.327 1.00 11.33 ? 171 SER A CB 1 ATOM 1201 O OG . SER A 1 187 ? 27.001 -8.199 48.711 1.00 15.12 ? 171 SER A OG 1 ATOM 1202 N N . GLU A 1 188 ? 29.673 -7.530 50.912 1.00 14.63 ? 172 GLU A N 1 ATOM 1203 C CA . GLU A 1 188 ? 29.571 -7.270 52.351 1.00 16.93 ? 172 GLU A CA 1 ATOM 1204 C C . GLU A 1 188 ? 28.216 -6.658 52.650 1.00 15.47 ? 172 GLU A C 1 ATOM 1205 O O . GLU A 1 188 ? 27.812 -5.684 52.041 1.00 18.57 ? 172 GLU A O 1 ATOM 1206 C CB . GLU A 1 188 ? 30.683 -6.350 52.858 1.00 20.08 ? 172 GLU A CB 1 ATOM 1207 C CG . GLU A 1 188 ? 30.672 -6.156 54.391 1.00 22.61 ? 172 GLU A CG 1 ATOM 1208 C CD . GLU A 1 188 ? 31.614 -5.047 54.882 1.00 32.79 ? 172 GLU A CD 1 ATOM 1209 O OE1 . GLU A 1 188 ? 32.448 -4.539 54.097 1.00 41.53 ? 172 GLU A OE1 1 ATOM 1210 O OE2 . GLU A 1 188 ? 31.516 -4.670 56.066 1.00 38.74 ? 172 GLU A OE2 1 ATOM 1211 N N . ILE A 1 189 ? 27.519 -7.255 53.599 1.00 17.13 ? 173 ILE A N 1 ATOM 1212 C CA . ILE A 1 189 ? 26.150 -6.885 53.930 1.00 24.99 ? 173 ILE A CA 1 ATOM 1213 C C . ILE A 1 189 ? 25.956 -6.755 55.450 1.00 22.72 ? 173 ILE A C 1 ATOM 1214 O O . ILE A 1 189 ? 26.467 -7.558 56.228 1.00 20.18 ? 173 ILE A O 1 ATOM 1215 C CB . ILE A 1 189 ? 25.155 -7.919 53.356 1.00 22.81 ? 173 ILE A CB 1 ATOM 1216 C CG1 . ILE A 1 189 ? 24.757 -7.515 51.935 1.00 27.33 ? 173 ILE A CG1 1 ATOM 1217 C CG2 . ILE A 1 189 ? 23.924 -8.029 54.231 1.00 23.31 ? 173 ILE A CG2 1 ATOM 1218 C CD1 . ILE A 1 189 ? 23.876 -8.513 51.219 1.00 26.41 ? 173 ILE A CD1 1 ATOM 1219 N N . GLN A 1 190 ? 25.227 -5.721 55.863 1.00 26.50 ? 174 GLN A N 1 ATOM 1220 C CA . GLN A 1 190 ? 24.967 -5.470 57.283 1.00 24.02 ? 174 GLN A CA 1 ATOM 1221 C C . GLN A 1 190 ? 23.610 -5.994 57.691 1.00 20.38 ? 174 GLN A C 1 ATOM 1222 O O . GLN A 1 190 ? 22.594 -5.665 57.082 1.00 25.98 ? 174 GLN A O 1 ATOM 1223 C CB . GLN A 1 190 ? 25.044 -3.980 57.578 1.00 25.64 ? 174 GLN A CB 1 ATOM 1224 C CG . GLN A 1 190 ? 26.438 -3.441 57.442 1.00 27.20 ? 174 GLN A CG 1 ATOM 1225 C CD . GLN A 1 190 ? 27.289 -3.741 58.648 1.00 20.25 ? 174 GLN A CD 1 ATOM 1226 O OE1 . GLN A 1 190 ? 26.795 -4.201 59.670 1.00 18.78 ? 174 GLN A OE1 1 ATOM 1227 N NE2 . GLN A 1 190 ? 28.577 -3.461 58.544 1.00 37.22 ? 174 GLN A NE2 1 ATOM 1228 N N . LEU A 1 191 ? 23.600 -6.821 58.725 1.00 20.87 ? 175 LEU A N 1 ATOM 1229 C CA . LEU A 1 191 ? 22.384 -7.502 59.145 1.00 25.65 ? 175 LEU A CA 1 ATOM 1230 C C . LEU A 1 191 ? 22.027 -7.098 60.565 1.00 24.63 ? 175 LEU A C 1 ATOM 1231 O O . LEU A 1 191 ? 22.899 -6.791 61.381 1.00 25.36 ? 175 LEU A O 1 ATOM 1232 C CB . LEU A 1 191 ? 22.569 -9.024 59.100 1.00 22.39 ? 175 LEU A CB 1 ATOM 1233 C CG . LEU A 1 191 ? 23.211 -9.594 57.843 1.00 20.15 ? 175 LEU A CG 1 ATOM 1234 C CD1 . LEU A 1 191 ? 23.599 -11.033 58.077 1.00 18.51 ? 175 LEU A CD1 1 ATOM 1235 C CD2 . LEU A 1 191 ? 22.266 -9.467 56.668 1.00 21.33 ? 175 LEU A CD2 1 ATOM 1236 N N . THR A 1 192 ? 20.738 -7.105 60.860 1.00 25.30 ? 176 THR A N 1 ATOM 1237 C CA . THR A 1 192 ? 20.299 -6.923 62.227 1.00 25.43 ? 176 THR A CA 1 ATOM 1238 C C . THR A 1 192 ? 20.805 -8.104 63.088 1.00 26.08 ? 176 THR A C 1 ATOM 1239 O O . THR A 1 192 ? 20.715 -9.273 62.707 1.00 21.15 ? 176 THR A O 1 ATOM 1240 C CB . THR A 1 192 ? 18.770 -6.766 62.277 1.00 27.83 ? 176 THR A CB 1 ATOM 1241 O OG1 . THR A 1 192 ? 18.344 -5.966 61.165 1.00 27.43 ? 176 THR A OG1 1 ATOM 1242 C CG2 . THR A 1 192 ? 18.332 -6.106 63.556 1.00 25.89 ? 176 THR A CG2 1 ATOM 1243 N N . ASP A 1 193 ? 21.402 -7.769 64.227 1.00 29.68 ? 177 ASP A N 1 ATOM 1244 C CA . ASP A 1 193 ? 21.827 -8.750 65.217 1.00 26.67 ? 177 ASP A CA 1 ATOM 1245 C C . ASP A 1 193 ? 23.068 -9.545 64.814 1.00 24.01 ? 177 ASP A C 1 ATOM 1246 O O . ASP A 1 193 ? 23.887 -9.852 65.666 1.00 23.67 ? 177 ASP A O 1 ATOM 1247 C CB . ASP A 1 193 ? 20.665 -9.701 65.571 1.00 38.08 ? 177 ASP A CB 1 ATOM 1248 C CG . ASP A 1 193 ? 20.094 -9.456 66.982 1.00 41.23 ? 177 ASP A CG 1 ATOM 1249 O OD1 . ASP A 1 193 ? 20.776 -9.788 67.988 1.00 39.59 ? 177 ASP A OD1 1 ATOM 1250 O OD2 . ASP A 1 193 ? 18.950 -8.948 67.078 1.00 47.87 ? 177 ASP A OD2 1 ATOM 1251 N N . TYR A 1 194 ? 23.214 -9.884 63.532 1.00 26.87 ? 178 TYR A N 1 ATOM 1252 C CA . TYR A 1 194 ? 24.367 -10.681 63.099 1.00 23.24 ? 178 TYR A CA 1 ATOM 1253 C C . TYR A 1 194 ? 25.598 -9.838 62.789 1.00 24.90 ? 178 TYR A C 1 ATOM 1254 O O . TYR A 1 194 ? 26.738 -10.298 62.954 1.00 31.56 ? 178 TYR A O 1 ATOM 1255 C CB . TYR A 1 194 ? 24.015 -11.558 61.900 1.00 21.85 ? 178 TYR A CB 1 ATOM 1256 C CG . TYR A 1 194 ? 23.313 -12.821 62.309 1.00 19.99 ? 178 TYR A CG 1 ATOM 1257 C CD1 . TYR A 1 194 ? 21.944 -12.847 62.448 1.00 21.79 ? 178 TYR A CD1 1 ATOM 1258 C CD2 . TYR A 1 194 ? 24.026 -13.979 62.597 1.00 16.44 ? 178 TYR A CD2 1 ATOM 1259 C CE1 . TYR A 1 194 ? 21.299 -13.985 62.832 1.00 20.22 ? 178 TYR A CE1 1 ATOM 1260 C CE2 . TYR A 1 194 ? 23.383 -15.125 62.987 1.00 16.34 ? 178 TYR A CE2 1 ATOM 1261 C CZ . TYR A 1 194 ? 22.019 -15.117 63.097 1.00 15.82 ? 178 TYR A CZ 1 ATOM 1262 O OH . TYR A 1 194 ? 21.337 -16.230 63.480 1.00 17.20 ? 178 TYR A OH 1 ATOM 1263 N N . GLY A 1 195 ? 25.377 -8.609 62.340 1.00 21.09 ? 179 GLY A N 1 ATOM 1264 C CA . GLY A 1 195 ? 26.471 -7.705 62.066 1.00 18.48 ? 179 GLY A CA 1 ATOM 1265 C C . GLY A 1 195 ? 26.863 -7.773 60.610 1.00 15.54 ? 179 GLY A C 1 ATOM 1266 O O . GLY A 1 195 ? 26.037 -8.113 59.762 1.00 16.70 ? 179 GLY A O 1 ATOM 1267 N N . ALA A 1 196 ? 28.119 -7.423 60.335 1.00 18.89 ? 180 ALA A N 1 ATOM 1268 C CA . ALA A 1 196 ? 28.686 -7.473 58.995 1.00 15.11 ? 180 ALA A CA 1 ATOM 1269 C C . ALA A 1 196 ? 28.886 -8.915 58.584 1.00 13.85 ? 180 ALA A C 1 ATOM 1270 O O . ALA A 1 196 ? 29.442 -9.703 59.323 1.00 15.35 ? 180 ALA A O 1 ATOM 1271 C CB . ALA A 1 196 ? 29.998 -6.715 58.946 1.00 16.98 ? 180 ALA A CB 1 ATOM 1272 N N . LEU A 1 197 ? 28.420 -9.255 57.395 1.00 13.78 ? 181 LEU A N 1 ATOM 1273 C CA . LEU A 1 197 ? 28.467 -10.622 56.901 1.00 15.02 ? 181 LEU A CA 1 ATOM 1274 C C . LEU A 1 197 ? 28.961 -10.547 55.473 1.00 12.36 ? 181 LEU A C 1 ATOM 1275 O O . LEU A 1 197 ? 28.363 -9.882 54.654 1.00 14.16 ? 181 LEU A O 1 ATOM 1276 C CB . LEU A 1 197 ? 27.059 -11.232 56.944 1.00 14.94 ? 181 LEU A CB 1 ATOM 1277 C CG . LEU A 1 197 ? 26.717 -12.664 56.487 1.00 15.50 ? 181 LEU A CG 1 ATOM 1278 C CD1 . LEU A 1 197 ? 27.424 -13.069 55.227 1.00 15.13 ? 181 LEU A CD1 1 ATOM 1279 C CD2 . LEU A 1 197 ? 26.983 -13.664 57.587 1.00 13.67 ? 181 LEU A CD2 1 ATOM 1280 N N . THR A 1 198 ? 30.067 -11.206 55.181 1.00 11.18 ? 182 THR A N 1 ATOM 1281 C CA . THR A 1 198 ? 30.578 -11.235 53.836 1.00 12.50 ? 182 THR A CA 1 ATOM 1282 C C . THR A 1 198 ? 30.086 -12.505 53.142 1.00 12.32 ? 182 THR A C 1 ATOM 1283 O O . THR A 1 198 ? 30.226 -13.604 53.678 1.00 14.25 ? 182 THR A O 1 ATOM 1284 C CB . THR A 1 198 ? 32.119 -11.145 53.829 1.00 12.78 ? 182 THR A CB 1 ATOM 1285 O OG1 . THR A 1 198 ? 32.529 -9.943 54.493 1.00 15.17 ? 182 THR A OG1 1 ATOM 1286 C CG2 . THR A 1 198 ? 32.653 -11.139 52.404 1.00 12.81 ? 182 THR A CG2 1 ATOM 1287 N N . LEU A 1 199 ? 29.470 -12.329 51.970 1.00 14.40 ? 183 LEU A N 1 ATOM 1288 C CA . LEU A 1 199 ? 29.174 -13.410 51.024 1.00 12.26 ? 183 LEU A CA 1 ATOM 1289 C C . LEU A 1 199 ? 30.291 -13.509 50.015 1.00 14.75 ? 183 LEU A C 1 ATOM 1290 O O . LEU A 1 199 ? 30.519 -12.580 49.247 1.00 13.85 ? 183 LEU A O 1 ATOM 1291 C CB . LEU A 1 199 ? 27.930 -13.095 50.209 1.00 13.95 ? 183 LEU A CB 1 ATOM 1292 C CG . LEU A 1 199 ? 26.528 -13.496 50.602 1.00 15.43 ? 183 LEU A CG 1 ATOM 1293 C CD1 . LEU A 1 199 ? 25.561 -13.037 49.508 1.00 13.33 ? 183 LEU A CD1 1 ATOM 1294 C CD2 . LEU A 1 199 ? 26.462 -14.987 50.759 1.00 18.39 ? 183 LEU A CD2 1 ATOM 1295 N N . ASP A 1 200 ? 30.959 -14.652 49.985 1.00 14.25 ? 184 ASP A N 1 ATOM 1296 C CA . ASP A 1 200 ? 32.037 -14.896 49.049 1.00 12.35 ? 184 ASP A CA 1 ATOM 1297 C C . ASP A 1 200 ? 31.635 -16.153 48.246 1.00 13.90 ? 184 ASP A C 1 ATOM 1298 O O . ASP A 1 200 ? 31.805 -17.287 48.701 1.00 13.16 ? 184 ASP A O 1 ATOM 1299 C CB . ASP A 1 200 ? 33.348 -15.074 49.831 1.00 12.22 ? 184 ASP A CB 1 ATOM 1300 C CG . ASP A 1 200 ? 34.593 -15.097 48.938 1.00 20.37 ? 184 ASP A CG 1 ATOM 1301 O OD1 . ASP A 1 200 ? 34.476 -15.320 47.722 1.00 25.42 ? 184 ASP A OD1 1 ATOM 1302 O OD2 . ASP A 1 200 ? 35.712 -14.906 49.463 1.00 32.02 ? 184 ASP A OD2 1 ATOM 1303 N N . CYS A 1 201 ? 31.069 -15.930 47.058 1.00 14.58 ? 185 CYS A N 1 ATOM 1304 C CA . CYS A 1 201 ? 30.395 -16.975 46.269 1.00 12.98 ? 185 CYS A CA 1 ATOM 1305 C C . CYS A 1 201 ? 31.048 -17.211 44.905 1.00 13.97 ? 185 CYS A C 1 ATOM 1306 O O . CYS A 1 201 ? 31.482 -16.261 44.258 1.00 19.50 ? 185 CYS A O 1 ATOM 1307 C CB . CYS A 1 201 ? 28.917 -16.594 46.046 1.00 11.67 ? 185 CYS A CB 1 ATOM 1308 S SG . CYS A 1 201 ? 27.846 -16.597 47.507 1.00 20.54 ? 185 CYS A SG 1 ATOM 1309 N N . SER A 1 202 ? 31.092 -18.469 44.462 1.00 11.58 ? 186 SER A N 1 ATOM 1310 C CA . SER A 1 202 ? 31.545 -18.817 43.114 1.00 11.91 ? 186 SER A CA 1 ATOM 1311 C C . SER A 1 202 ? 30.549 -19.743 42.439 1.00 10.33 ? 186 SER A C 1 ATOM 1312 O O . SER A 1 202 ? 29.818 -20.458 43.105 1.00 11.19 ? 186 SER A O 1 ATOM 1313 C CB . SER A 1 202 ? 32.889 -19.528 43.167 1.00 15.46 ? 186 SER A CB 1 ATOM 1314 O OG . SER A 1 202 ? 33.888 -18.696 43.704 1.00 20.84 ? 186 SER A OG 1 ATOM 1315 N N . PRO A 1 203 ? 30.524 -19.750 41.102 1.00 15.32 ? 187 PRO A N 1 ATOM 1316 C CA . PRO A 1 203 ? 29.729 -20.783 40.433 1.00 11.86 ? 187 PRO A CA 1 ATOM 1317 C C . PRO A 1 203 ? 30.270 -22.189 40.682 1.00 13.10 ? 187 PRO A C 1 ATOM 1318 O O . PRO A 1 203 ? 31.487 -22.428 40.759 1.00 13.89 ? 187 PRO A O 1 ATOM 1319 C CB . PRO A 1 203 ? 29.858 -20.421 38.950 1.00 15.18 ? 187 PRO A CB 1 ATOM 1320 C CG . PRO A 1 203 ? 30.339 -19.010 38.932 1.00 11.25 ? 187 PRO A CG 1 ATOM 1321 C CD . PRO A 1 203 ? 31.178 -18.852 40.137 1.00 10.18 ? 187 PRO A CD 1 ATOM 1322 N N . ARG A 1 204 ? 29.346 -23.122 40.829 1.00 12.40 ? 188 ARG A N 1 ATOM 1323 C CA . ARG A 1 204 ? 29.695 -24.515 40.972 1.00 14.90 ? 188 ARG A CA 1 ATOM 1324 C C . ARG A 1 204 ? 30.110 -25.007 39.613 1.00 14.13 ? 188 ARG A C 1 ATOM 1325 O O . ARG A 1 204 ? 29.772 -24.415 38.603 1.00 18.80 ? 188 ARG A O 1 ATOM 1326 C CB . ARG A 1 204 ? 28.509 -25.311 41.504 1.00 17.12 ? 188 ARG A CB 1 ATOM 1327 C CG . ARG A 1 204 ? 28.349 -25.234 43.016 1.00 15.93 ? 188 ARG A CG 1 ATOM 1328 C CD . ARG A 1 204 ? 27.718 -26.488 43.564 1.00 18.70 ? 188 ARG A CD 1 ATOM 1329 N NE . ARG A 1 204 ? 26.349 -26.605 43.098 1.00 25.82 ? 188 ARG A NE 1 ATOM 1330 C CZ . ARG A 1 204 ? 25.537 -27.631 43.341 1.00 31.83 ? 188 ARG A CZ 1 ATOM 1331 N NH1 . ARG A 1 204 ? 25.964 -28.659 44.065 1.00 27.04 ? 188 ARG A NH1 1 ATOM 1332 N NH2 . ARG A 1 204 ? 24.297 -27.631 42.858 1.00 26.38 ? 188 ARG A NH2 1 ATOM 1333 N N . THR A 1 205 ? 30.857 -26.091 39.582 1.00 13.60 ? 189 THR A N 1 ATOM 1334 C CA . THR A 1 205 ? 31.296 -26.659 38.324 1.00 16.12 ? 189 THR A CA 1 ATOM 1335 C C . THR A 1 205 ? 30.130 -27.407 37.705 1.00 11.73 ? 189 THR A C 1 ATOM 1336 O O . THR A 1 205 ? 29.537 -28.285 38.324 1.00 12.16 ? 189 THR A O 1 ATOM 1337 C CB . THR A 1 205 ? 32.507 -27.613 38.520 1.00 15.36 ? 189 THR A CB 1 ATOM 1338 O OG1 . THR A 1 205 ? 33.639 -26.868 38.985 1.00 18.64 ? 189 THR A OG1 1 ATOM 1339 C CG2 . THR A 1 205 ? 32.880 -28.319 37.220 1.00 12.50 ? 189 THR A CG2 1 ATOM 1340 N N . GLY A 1 206 ? 29.807 -27.044 36.473 1.00 13.78 ? 190 GLY A N 1 ATOM 1341 C CA . GLY A 1 206 ? 28.670 -27.595 35.765 1.00 10.70 ? 190 GLY A CA 1 ATOM 1342 C C . GLY A 1 206 ? 28.761 -27.190 34.317 1.00 14.11 ? 190 GLY A C 1 ATOM 1343 O O . GLY A 1 206 ? 29.595 -27.704 33.601 1.00 14.98 ? 190 GLY A O 1 ATOM 1344 N N . LEU A 1 207 ? 27.897 -26.270 33.888 1.00 16.11 ? 191 LEU A N 1 ATOM 1345 C CA . LEU A 1 207 ? 27.970 -25.727 32.535 1.00 18.52 ? 191 LEU A CA 1 ATOM 1346 C C . LEU A 1 207 ? 29.286 -25.014 32.318 1.00 18.13 ? 191 LEU A C 1 ATOM 1347 O O . LEU A 1 207 ? 29.740 -24.264 33.174 1.00 20.08 ? 191 LEU A O 1 ATOM 1348 C CB . LEU A 1 207 ? 26.855 -24.718 32.277 1.00 22.28 ? 191 LEU A CB 1 ATOM 1349 C CG . LEU A 1 207 ? 25.615 -25.113 31.486 1.00 21.50 ? 191 LEU A CG 1 ATOM 1350 C CD1 . LEU A 1 207 ? 24.822 -23.859 31.203 1.00 20.44 ? 191 LEU A CD1 1 ATOM 1351 C CD2 . LEU A 1 207 ? 25.955 -25.831 30.194 1.00 20.20 ? 191 LEU A CD2 1 ATOM 1352 N N . ASP A 1 208 ? 29.873 -25.205 31.148 1.00 16.04 ? 192 ASP A N 1 ATOM 1353 C CA . ASP A 1 208 ? 31.179 -24.650 30.876 1.00 14.84 ? 192 ASP A CA 1 ATOM 1354 C C . ASP A 1 208 ? 31.065 -23.721 29.705 1.00 14.30 ? 192 ASP A C 1 ATOM 1355 O O . ASP A 1 208 ? 30.926 -24.176 28.580 1.00 10.63 ? 192 ASP A O 1 ATOM 1356 C CB . ASP A 1 208 ? 32.172 -25.769 30.561 1.00 15.56 ? 192 ASP A CB 1 ATOM 1357 C CG . ASP A 1 208 ? 33.553 -25.250 30.278 1.00 14.41 ? 192 ASP A CG 1 ATOM 1358 O OD1 . ASP A 1 208 ? 33.705 -24.016 30.212 1.00 20.01 ? 192 ASP A OD1 1 ATOM 1359 O OD2 . ASP A 1 208 ? 34.488 -26.054 30.120 1.00 17.59 ? 192 ASP A OD2 1 ATOM 1360 N N . PHE A 1 209 ? 31.150 -22.422 29.977 1.00 14.66 ? 193 PHE A N 1 ATOM 1361 C CA . PHE A 1 209 ? 30.966 -21.402 28.940 1.00 13.50 ? 193 PHE A CA 1 ATOM 1362 C C . PHE A 1 209 ? 32.206 -21.216 28.061 1.00 11.99 ? 193 PHE A C 1 ATOM 1363 O O . PHE A 1 209 ? 32.202 -20.426 27.123 1.00 12.07 ? 193 PHE A O 1 ATOM 1364 C CB . PHE A 1 209 ? 30.491 -20.068 29.550 1.00 11.88 ? 193 PHE A CB 1 ATOM 1365 C CG . PHE A 1 209 ? 29.093 -20.126 30.108 1.00 10.44 ? 193 PHE A CG 1 ATOM 1366 C CD1 . PHE A 1 209 ? 28.048 -20.571 29.333 1.00 10.92 ? 193 PHE A CD1 1 ATOM 1367 C CD2 . PHE A 1 209 ? 28.835 -19.761 31.411 1.00 14.15 ? 193 PHE A CD2 1 ATOM 1368 C CE1 . PHE A 1 209 ? 26.771 -20.644 29.841 1.00 14.80 ? 193 PHE A CE1 1 ATOM 1369 C CE2 . PHE A 1 209 ? 27.556 -19.835 31.933 1.00 16.83 ? 193 PHE A CE2 1 ATOM 1370 C CZ . PHE A 1 209 ? 26.520 -20.272 31.141 1.00 19.18 ? 193 PHE A CZ 1 ATOM 1371 N N . ASN A 1 210 ? 33.255 -21.972 28.346 1.00 13.21 ? 194 ASN A N 1 ATOM 1372 C CA . ASN A 1 210 ? 34.392 -22.036 27.446 1.00 14.77 ? 194 ASN A CA 1 ATOM 1373 C C . ASN A 1 210 ? 34.106 -22.941 26.269 1.00 11.68 ? 194 ASN A C 1 ATOM 1374 O O . ASN A 1 210 ? 34.664 -22.776 25.200 1.00 9.49 ? 194 ASN A O 1 ATOM 1375 C CB . ASN A 1 210 ? 35.610 -22.559 28.177 1.00 15.90 ? 194 ASN A CB 1 ATOM 1376 C CG . ASN A 1 210 ? 36.150 -21.572 29.151 1.00 20.06 ? 194 ASN A CG 1 ATOM 1377 O OD1 . ASN A 1 210 ? 35.695 -21.509 30.283 1.00 29.57 ? 194 ASN A OD1 1 ATOM 1378 N ND2 . ASN A 1 210 ? 37.127 -20.786 28.727 1.00 21.60 ? 194 ASN A ND2 1 ATOM 1379 N N . GLU A 1 211 ? 33.214 -23.901 26.488 1.00 13.81 ? 195 GLU A N 1 ATOM 1380 C CA . GLU A 1 211 ? 32.888 -24.931 25.496 1.00 12.77 ? 195 GLU A CA 1 ATOM 1381 C C . GLU A 1 211 ? 31.515 -24.732 24.847 1.00 10.43 ? 195 GLU A C 1 ATOM 1382 O O . GLU A 1 211 ? 31.361 -25.006 23.674 1.00 10.10 ? 195 GLU A O 1 ATOM 1383 C CB . GLU A 1 211 ? 32.970 -26.316 26.145 1.00 10.51 ? 195 GLU A CB 1 ATOM 1384 C CG . GLU A 1 211 ? 32.442 -27.469 25.304 1.00 11.76 ? 195 GLU A CG 1 ATOM 1385 C CD . GLU A 1 211 ? 33.126 -27.582 23.959 1.00 12.11 ? 195 GLU A CD 1 ATOM 1386 O OE1 . GLU A 1 211 ? 34.181 -26.952 23.788 1.00 14.36 ? 195 GLU A OE1 1 ATOM 1387 O OE2 . GLU A 1 211 ? 32.609 -28.305 23.077 1.00 11.68 ? 195 GLU A OE2 1 ATOM 1388 N N . MET A 1 212 ? 30.539 -24.237 25.604 1.00 11.60 ? 196 MET A N 1 ATOM 1389 C CA . MET A 1 212 ? 29.171 -24.103 25.110 1.00 9.66 ? 196 MET A CA 1 ATOM 1390 C C . MET A 1 212 ? 28.857 -22.685 24.675 1.00 11.08 ? 196 MET A C 1 ATOM 1391 O O . MET A 1 212 ? 29.193 -21.715 25.364 1.00 14.83 ? 196 MET A O 1 ATOM 1392 C CB . MET A 1 212 ? 28.172 -24.513 26.190 1.00 12.41 ? 196 MET A CB 1 ATOM 1393 C CG . MET A 1 212 ? 28.358 -25.915 26.720 1.00 11.55 ? 196 MET A CG 1 ATOM 1394 S SD . MET A 1 212 ? 28.408 -27.137 25.449 1.00 7.52 ? 196 MET A SD 1 ATOM 1395 C CE . MET A 1 212 ? 26.704 -27.136 24.943 1.00 9.51 ? 196 MET A CE 1 ATOM 1396 N N . VAL A 1 213 ? 28.192 -22.578 23.534 1.00 10.22 ? 197 VAL A N 1 ATOM 1397 C CA . VAL A 1 213 ? 27.876 -21.292 22.941 1.00 12.48 ? 197 VAL A CA 1 ATOM 1398 C C . VAL A 1 213 ? 26.363 -21.075 22.927 1.00 8.93 ? 197 VAL A C 1 ATOM 1399 O O . VAL A 1 213 ? 25.603 -22.009 22.845 1.00 9.81 ? 197 VAL A O 1 ATOM 1400 C CB . VAL A 1 213 ? 28.480 -21.196 21.516 1.00 10.91 ? 197 VAL A CB 1 ATOM 1401 C CG1 . VAL A 1 213 ? 27.534 -20.482 20.558 1.00 14.49 ? 197 VAL A CG1 1 ATOM 1402 C CG2 . VAL A 1 213 ? 29.819 -20.515 21.576 1.00 10.70 ? 197 VAL A CG2 1 ATOM 1403 N N . LEU A 1 214 ? 25.944 -19.828 23.011 1.00 8.25 ? 198 LEU A N 1 ATOM 1404 C CA . LEU A 1 214 ? 24.546 -19.496 22.997 1.00 8.82 ? 198 LEU A CA 1 ATOM 1405 C C . LEU A 1 214 ? 24.128 -19.295 21.547 1.00 9.39 ? 198 LEU A C 1 ATOM 1406 O O . LEU A 1 214 ? 24.593 -18.394 20.896 1.00 10.57 ? 198 LEU A O 1 ATOM 1407 C CB . LEU A 1 214 ? 24.377 -18.219 23.801 1.00 11.28 ? 198 LEU A CB 1 ATOM 1408 C CG . LEU A 1 214 ? 23.094 -17.925 24.551 1.00 15.19 ? 198 LEU A CG 1 ATOM 1409 C CD1 . LEU A 1 214 ? 22.488 -19.201 25.115 1.00 20.88 ? 198 LEU A CD1 1 ATOM 1410 C CD2 . LEU A 1 214 ? 23.413 -16.960 25.673 1.00 14.97 ? 198 LEU A CD2 1 ATOM 1411 N N . LEU A 1 215 ? 23.273 -20.156 21.024 1.00 10.64 ? 199 LEU A N 1 ATOM 1412 C CA . LEU A 1 215 ? 22.814 -20.025 19.647 1.00 9.31 ? 199 LEU A CA 1 ATOM 1413 C C . LEU A 1 215 ? 21.407 -19.448 19.641 1.00 11.04 ? 199 LEU A C 1 ATOM 1414 O O . LEU A 1 215 ? 20.547 -19.965 20.318 1.00 11.55 ? 199 LEU A O 1 ATOM 1415 C CB . LEU A 1 215 ? 22.834 -21.396 18.964 1.00 11.35 ? 199 LEU A CB 1 ATOM 1416 C CG . LEU A 1 215 ? 22.600 -21.432 17.462 1.00 10.04 ? 199 LEU A CG 1 ATOM 1417 C CD1 . LEU A 1 215 ? 23.452 -22.507 16.836 1.00 10.68 ? 199 LEU A CD1 1 ATOM 1418 C CD2 . LEU A 1 215 ? 21.133 -21.667 17.145 1.00 11.09 ? 199 LEU A CD2 1 ATOM 1419 N N . THR A 1 216 ? 21.188 -18.369 18.890 1.00 10.09 ? 200 THR A N 1 ATOM 1420 C CA . THR A 1 216 ? 19.878 -17.725 18.782 1.00 13.86 ? 200 THR A CA 1 ATOM 1421 C C . THR A 1 216 ? 19.415 -17.656 17.336 1.00 15.13 ? 200 THR A C 1 ATOM 1422 O O . THR A 1 216 ? 20.008 -16.970 16.519 1.00 17.85 ? 200 THR A O 1 ATOM 1423 C CB . THR A 1 216 ? 19.915 -16.294 19.328 1.00 20.13 ? 200 THR A CB 1 ATOM 1424 O OG1 . THR A 1 216 ? 20.438 -16.304 20.664 1.00 20.27 ? 200 THR A OG1 1 ATOM 1425 C CG2 . THR A 1 216 ? 18.514 -15.678 19.323 1.00 28.10 ? 200 THR A CG2 1 ATOM 1426 N N . MET A 1 217 ? 18.349 -18.368 17.019 1.00 15.32 ? 201 MET A N 1 ATOM 1427 C CA . MET A 1 217 ? 17.789 -18.349 15.681 1.00 18.36 ? 201 MET A CA 1 ATOM 1428 C C . MET A 1 217 ? 16.323 -17.940 15.743 1.00 25.12 ? 201 MET A C 1 ATOM 1429 O O . MET A 1 217 ? 15.514 -18.604 16.381 1.00 23.08 ? 201 MET A O 1 ATOM 1430 C CB . MET A 1 217 ? 17.911 -19.718 15.039 1.00 15.96 ? 201 MET A CB 1 ATOM 1431 C CG . MET A 1 217 ? 17.151 -19.836 13.726 1.00 18.33 ? 201 MET A CG 1 ATOM 1432 S SD . MET A 1 217 ? 17.092 -21.518 13.124 1.00 22.08 ? 201 MET A SD 1 ATOM 1433 C CE . MET A 1 217 ? 18.630 -21.529 12.271 1.00 16.38 ? 201 MET A CE 1 ATOM 1434 N N . GLU A 1 218 ? 15.986 -16.846 15.071 1.00 30.55 ? 202 GLU A N 1 ATOM 1435 C CA . GLU A 1 218 ? 14.668 -16.249 15.224 1.00 33.01 ? 202 GLU A CA 1 ATOM 1436 C C . GLU A 1 218 ? 14.441 -15.932 16.712 1.00 30.44 ? 202 GLU A C 1 ATOM 1437 O O . GLU A 1 218 ? 15.134 -15.092 17.288 1.00 33.95 ? 202 GLU A O 1 ATOM 1438 C CB . GLU A 1 218 ? 13.582 -17.174 14.665 1.00 33.31 ? 202 GLU A CB 1 ATOM 1439 C CG . GLU A 1 218 ? 13.747 -17.533 13.178 1.00 38.33 ? 202 GLU A CG 1 ATOM 1440 C CD . GLU A 1 218 ? 12.789 -16.784 12.250 1.00 45.73 ? 202 GLU A CD 1 ATOM 1441 O OE1 . GLU A 1 218 ? 12.266 -15.716 12.643 1.00 51.92 ? 202 GLU A OE1 1 ATOM 1442 O OE2 . GLU A 1 218 ? 12.553 -17.281 11.124 1.00 42.00 ? 202 GLU A OE2 1 ATOM 1443 N N . LYS A 1 219 ? 13.500 -16.614 17.341 1.00 25.97 ? 203 LYS A N 1 ATOM 1444 C CA . LYS A 1 219 ? 13.152 -16.284 18.710 1.00 39.16 ? 203 LYS A CA 1 ATOM 1445 C C . LYS A 1 219 ? 13.607 -17.325 19.753 1.00 33.79 ? 203 LYS A C 1 ATOM 1446 O O . LYS A 1 219 ? 13.561 -17.050 20.945 1.00 38.43 ? 203 LYS A O 1 ATOM 1447 C CB . LYS A 1 219 ? 11.643 -16.048 18.794 1.00 49.36 ? 203 LYS A CB 1 ATOM 1448 C CG . LYS A 1 219 ? 11.101 -15.841 20.205 1.00 58.61 ? 203 LYS A CG 1 ATOM 1449 C CD . LYS A 1 219 ? 9.582 -15.956 20.225 1.00 63.83 ? 203 LYS A CD 1 ATOM 1450 C CE . LYS A 1 219 ? 9.025 -15.789 21.629 1.00 67.21 ? 203 LYS A CE 1 ATOM 1451 N NZ . LYS A 1 219 ? 7.933 -16.773 21.893 1.00 67.44 ? 203 LYS A NZ 1 ATOM 1452 N N . LYS A 1 220 ? 14.060 -18.498 19.323 1.00 27.50 ? 204 LYS A N 1 ATOM 1453 C CA . LYS A 1 220 ? 14.474 -19.527 20.271 1.00 20.89 ? 204 LYS A CA 1 ATOM 1454 C C . LYS A 1 220 ? 15.986 -19.483 20.500 1.00 19.65 ? 204 LYS A C 1 ATOM 1455 O O . LYS A 1 220 ? 16.711 -18.902 19.702 1.00 19.15 ? 204 LYS A O 1 ATOM 1456 C CB . LYS A 1 220 ? 14.029 -20.908 19.775 1.00 25.44 ? 204 LYS A CB 1 ATOM 1457 C CG . LYS A 1 220 ? 12.862 -21.535 20.554 1.00 34.22 ? 204 LYS A CG 1 ATOM 1458 C CD . LYS A 1 220 ? 11.521 -20.821 20.329 1.00 38.04 ? 204 LYS A CD 1 ATOM 1459 C CE . LYS A 1 220 ? 11.090 -19.938 21.525 1.00 43.94 ? 204 LYS A CE 1 ATOM 1460 N NZ . LYS A 1 220 ? 10.449 -20.675 22.671 1.00 37.04 ? 204 LYS A NZ 1 ATOM 1461 N N . SER A 1 221 ? 16.453 -20.071 21.602 1.00 16.24 ? 205 SER A N 1 ATOM 1462 C CA . SER A 1 221 ? 17.885 -20.199 21.879 1.00 13.50 ? 205 SER A CA 1 ATOM 1463 C C . SER A 1 221 ? 18.241 -21.603 22.355 1.00 12.10 ? 205 SER A C 1 ATOM 1464 O O . SER A 1 221 ? 17.417 -22.300 22.929 1.00 13.11 ? 205 SER A O 1 ATOM 1465 C CB . SER A 1 221 ? 18.352 -19.185 22.929 1.00 15.24 ? 205 SER A CB 1 ATOM 1466 O OG . SER A 1 221 ? 17.965 -17.872 22.593 1.00 21.60 ? 205 SER A OG 1 ATOM 1467 N N . TRP A 1 222 ? 19.483 -22.002 22.111 1.00 10.91 ? 206 TRP A N 1 ATOM 1468 C CA . TRP A 1 222 ? 19.997 -23.285 22.549 1.00 8.51 ? 206 TRP A CA 1 ATOM 1469 C C . TRP A 1 222 ? 21.408 -23.119 23.073 1.00 10.42 ? 206 TRP A C 1 ATOM 1470 O O . TRP A 1 222 ? 22.096 -22.177 22.700 1.00 11.17 ? 206 TRP A O 1 ATOM 1471 C CB . TRP A 1 222 ? 20.055 -24.250 21.377 1.00 10.95 ? 206 TRP A CB 1 ATOM 1472 C CG . TRP A 1 222 ? 18.731 -24.620 20.805 1.00 13.98 ? 206 TRP A CG 1 ATOM 1473 C CD1 . TRP A 1 222 ? 17.995 -25.727 21.095 1.00 12.14 ? 206 TRP A CD1 1 ATOM 1474 C CD2 . TRP A 1 222 ? 17.983 -23.886 19.826 1.00 14.79 ? 206 TRP A CD2 1 ATOM 1475 N NE1 . TRP A 1 222 ? 16.841 -25.726 20.359 1.00 14.91 ? 206 TRP A NE1 1 ATOM 1476 C CE2 . TRP A 1 222 ? 16.808 -24.607 19.576 1.00 13.94 ? 206 TRP A CE2 1 ATOM 1477 C CE3 . TRP A 1 222 ? 18.199 -22.688 19.142 1.00 13.16 ? 206 TRP A CE3 1 ATOM 1478 C CZ2 . TRP A 1 222 ? 15.851 -24.170 18.666 1.00 14.84 ? 206 TRP A CZ2 1 ATOM 1479 C CZ3 . TRP A 1 222 ? 17.247 -22.263 18.243 1.00 11.83 ? 206 TRP A CZ3 1 ATOM 1480 C CH2 . TRP A 1 222 ? 16.094 -22.996 18.017 1.00 15.86 ? 206 TRP A CH2 1 ATOM 1481 N N . LEU A 1 223 ? 21.854 -24.035 23.921 1.00 8.73 ? 207 LEU A N 1 ATOM 1482 C CA . LEU A 1 223 ? 23.275 -24.161 24.182 1.00 9.80 ? 207 LEU A CA 1 ATOM 1483 C C . LEU A 1 223 ? 23.864 -25.202 23.256 1.00 7.53 ? 207 LEU A C 1 ATOM 1484 O O . LEU A 1 223 ? 23.423 -26.329 23.248 1.00 10.24 ? 207 LEU A O 1 ATOM 1485 C CB . LEU A 1 223 ? 23.548 -24.568 25.624 1.00 11.72 ? 207 LEU A CB 1 ATOM 1486 C CG . LEU A 1 223 ? 23.294 -23.519 26.699 1.00 14.53 ? 207 LEU A CG 1 ATOM 1487 C CD1 . LEU A 1 223 ? 24.066 -22.253 26.414 1.00 12.62 ? 207 LEU A CD1 1 ATOM 1488 C CD2 . LEU A 1 223 ? 21.813 -23.239 26.831 1.00 19.39 ? 207 LEU A CD2 1 ATOM 1489 N N . VAL A 1 224 ? 24.871 -24.818 22.480 1.00 8.50 ? 208 VAL A N 1 ATOM 1490 C CA . VAL A 1 224 ? 25.529 -25.732 21.551 1.00 9.00 ? 208 VAL A CA 1 ATOM 1491 C C . VAL A 1 224 ? 27.038 -25.723 21.755 1.00 7.95 ? 208 VAL A C 1 ATOM 1492 O O . VAL A 1 224 ? 27.583 -24.771 22.280 1.00 8.81 ? 208 VAL A O 1 ATOM 1493 C CB . VAL A 1 224 ? 25.203 -25.368 20.083 1.00 9.99 ? 208 VAL A CB 1 ATOM 1494 C CG1 . VAL A 1 224 ? 23.711 -25.336 19.880 1.00 8.45 ? 208 VAL A CG1 1 ATOM 1495 C CG2 . VAL A 1 224 ? 25.819 -24.019 19.677 1.00 7.47 ? 208 VAL A CG2 1 ATOM 1496 N N . HIS A 1 225 ? 27.710 -26.782 21.326 1.00 10.35 ? 209 HIS A N 1 ATOM 1497 C CA . HIS A 1 225 ? 29.150 -26.846 21.441 1.00 6.99 ? 209 HIS A CA 1 ATOM 1498 C C . HIS A 1 225 ? 29.785 -25.884 20.457 1.00 7.90 ? 209 HIS A C 1 ATOM 1499 O O . HIS A 1 225 ? 29.236 -25.599 19.394 1.00 7.19 ? 209 HIS A O 1 ATOM 1500 C CB . HIS A 1 225 ? 29.647 -28.275 21.219 1.00 10.29 ? 209 HIS A CB 1 ATOM 1501 C CG . HIS A 1 225 ? 29.393 -29.195 22.375 1.00 7.88 ? 209 HIS A CG 1 ATOM 1502 N ND1 . HIS A 1 225 ? 30.363 -29.529 23.300 1.00 11.27 ? 209 HIS A ND1 1 ATOM 1503 C CD2 . HIS A 1 225 ? 28.282 -29.883 22.746 1.00 9.75 ? 209 HIS A CD2 1 ATOM 1504 C CE1 . HIS A 1 225 ? 29.861 -30.352 24.195 1.00 9.53 ? 209 HIS A CE1 1 ATOM 1505 N NE2 . HIS A 1 225 ? 28.593 -30.576 23.887 1.00 14.10 ? 209 HIS A NE2 1 ATOM 1506 N N . LYS A 1 226 ? 30.951 -25.377 20.832 1.00 9.02 ? 210 LYS A N 1 ATOM 1507 C CA . LYS A 1 226 ? 31.594 -24.279 20.111 1.00 7.96 ? 210 LYS A CA 1 ATOM 1508 C C . LYS A 1 226 ? 32.135 -24.670 18.739 1.00 6.81 ? 210 LYS A C 1 ATOM 1509 O O . LYS A 1 226 ? 32.020 -23.920 17.799 1.00 8.43 ? 210 LYS A O 1 ATOM 1510 C CB . LYS A 1 226 ? 32.713 -23.680 20.966 1.00 9.26 ? 210 LYS A CB 1 ATOM 1511 C CG . LYS A 1 226 ? 33.440 -22.514 20.329 1.00 12.37 ? 210 LYS A CG 1 ATOM 1512 C CD . LYS A 1 226 ? 34.439 -21.856 21.278 1.00 11.59 ? 210 LYS A CD 1 ATOM 1513 C CE . LYS A 1 226 ? 33.777 -20.740 22.089 1.00 14.71 ? 210 LYS A CE 1 ATOM 1514 N NZ . LYS A 1 226 ? 34.734 -19.961 22.939 1.00 15.22 ? 210 LYS A NZ 1 ATOM 1515 N N . GLN A 1 227 ? 32.739 -25.837 18.620 1.00 9.69 ? 211 GLN A N 1 ATOM 1516 C CA . GLN A 1 227 ? 33.370 -26.203 17.367 1.00 8.52 ? 211 GLN A CA 1 ATOM 1517 C C . GLN A 1 227 ? 32.302 -26.729 16.448 1.00 8.78 ? 211 GLN A C 1 ATOM 1518 O O . GLN A 1 227 ? 32.434 -26.639 15.225 1.00 8.49 ? 211 GLN A O 1 ATOM 1519 C CB . GLN A 1 227 ? 34.472 -27.254 17.553 1.00 11.41 ? 211 GLN A CB 1 ATOM 1520 C CG . GLN A 1 227 ? 35.428 -27.385 16.341 1.00 9.32 ? 211 GLN A CG 1 ATOM 1521 C CD . GLN A 1 227 ? 36.084 -26.065 15.995 1.00 10.49 ? 211 GLN A CD 1 ATOM 1522 O OE1 . GLN A 1 227 ? 36.369 -25.273 16.877 1.00 15.99 ? 211 GLN A OE1 1 ATOM 1523 N NE2 . GLN A 1 227 ? 36.295 -25.811 14.719 1.00 13.23 ? 211 GLN A NE2 1 ATOM 1524 N N . TRP A 1 228 ? 31.253 -27.297 17.038 1.00 7.17 ? 212 TRP A N 1 ATOM 1525 C CA . TRP A 1 228 ? 30.072 -27.689 16.278 1.00 7.90 ? 212 TRP A CA 1 ATOM 1526 C C . TRP A 1 228 ? 29.595 -26.473 15.481 1.00 8.93 ? 212 TRP A C 1 ATOM 1527 O O . TRP A 1 228 ? 29.450 -26.523 14.264 1.00 8.90 ? 212 TRP A O 1 ATOM 1528 C CB . TRP A 1 228 ? 28.975 -28.209 17.212 1.00 8.30 ? 212 TRP A CB 1 ATOM 1529 C CG . TRP A 1 228 ? 27.723 -28.612 16.517 1.00 8.65 ? 212 TRP A CG 1 ATOM 1530 C CD1 . TRP A 1 228 ? 27.424 -29.835 15.993 1.00 9.17 ? 212 TRP A CD1 1 ATOM 1531 C CD2 . TRP A 1 228 ? 26.600 -27.778 16.248 1.00 9.32 ? 212 TRP A CD2 1 ATOM 1532 N NE1 . TRP A 1 228 ? 26.178 -29.812 15.419 1.00 9.28 ? 212 TRP A NE1 1 ATOM 1533 C CE2 . TRP A 1 228 ? 25.653 -28.554 15.555 1.00 9.77 ? 212 TRP A CE2 1 ATOM 1534 C CE3 . TRP A 1 228 ? 26.302 -26.439 16.519 1.00 7.80 ? 212 TRP A CE3 1 ATOM 1535 C CZ2 . TRP A 1 228 ? 24.429 -28.051 15.145 1.00 8.16 ? 212 TRP A CZ2 1 ATOM 1536 C CZ3 . TRP A 1 228 ? 25.092 -25.941 16.118 1.00 9.29 ? 212 TRP A CZ3 1 ATOM 1537 C CH2 . TRP A 1 228 ? 24.165 -26.746 15.430 1.00 9.26 ? 212 TRP A CH2 1 ATOM 1538 N N . PHE A 1 229 ? 29.391 -25.373 16.196 1.00 8.48 ? 213 PHE A N 1 ATOM 1539 C CA . PHE A 1 229 ? 28.970 -24.105 15.630 1.00 7.91 ? 213 PHE A CA 1 ATOM 1540 C C . PHE A 1 229 ? 29.963 -23.567 14.581 1.00 6.11 ? 213 PHE A C 1 ATOM 1541 O O . PHE A 1 229 ? 29.577 -23.285 13.456 1.00 7.70 ? 213 PHE A O 1 ATOM 1542 C CB . PHE A 1 229 ? 28.759 -23.085 16.776 1.00 5.55 ? 213 PHE A CB 1 ATOM 1543 C CG . PHE A 1 229 ? 28.477 -21.682 16.305 1.00 5.79 ? 213 PHE A CG 1 ATOM 1544 C CD1 . PHE A 1 229 ? 27.234 -21.339 15.836 1.00 5.52 ? 213 PHE A CD1 1 ATOM 1545 C CD2 . PHE A 1 229 ? 29.473 -20.719 16.328 1.00 6.39 ? 213 PHE A CD2 1 ATOM 1546 C CE1 . PHE A 1 229 ? 26.982 -20.070 15.389 1.00 6.92 ? 213 PHE A CE1 1 ATOM 1547 C CE2 . PHE A 1 229 ? 29.230 -19.445 15.900 1.00 7.88 ? 213 PHE A CE2 1 ATOM 1548 C CZ . PHE A 1 229 ? 27.968 -19.120 15.422 1.00 7.76 ? 213 PHE A CZ 1 ATOM 1549 N N . LEU A 1 230 ? 31.236 -23.462 14.951 1.00 7.12 ? 214 LEU A N 1 ATOM 1550 C CA . LEU A 1 230 ? 32.274 -22.908 14.086 1.00 8.11 ? 214 LEU A CA 1 ATOM 1551 C C . LEU A 1 230 ? 32.472 -23.689 12.790 1.00 11.10 ? 214 LEU A C 1 ATOM 1552 O O . LEU A 1 230 ? 32.969 -23.157 11.799 1.00 13.86 ? 214 LEU A O 1 ATOM 1553 C CB . LEU A 1 230 ? 33.609 -22.877 14.825 1.00 8.52 ? 214 LEU A CB 1 ATOM 1554 C CG . LEU A 1 230 ? 33.770 -21.922 15.991 1.00 8.82 ? 214 LEU A CG 1 ATOM 1555 C CD1 . LEU A 1 230 ? 35.183 -22.022 16.511 1.00 9.33 ? 214 LEU A CD1 1 ATOM 1556 C CD2 . LEU A 1 230 ? 33.443 -20.520 15.543 1.00 12.21 ? 214 LEU A CD2 1 ATOM 1557 N N . ASP A 1 231 ? 32.096 -24.953 12.805 1.00 9.81 ? 215 ASP A N 1 ATOM 1558 C CA . ASP A 1 231 ? 32.297 -25.810 11.660 1.00 10.81 ? 215 ASP A CA 1 ATOM 1559 C C . ASP A 1 231 ? 31.008 -25.950 10.836 1.00 11.72 ? 215 ASP A C 1 ATOM 1560 O O . ASP A 1 231 ? 30.974 -26.693 9.874 1.00 13.03 ? 215 ASP A O 1 ATOM 1561 C CB . ASP A 1 231 ? 32.786 -27.195 12.112 1.00 12.99 ? 215 ASP A CB 1 ATOM 1562 C CG . ASP A 1 231 ? 34.291 -27.230 12.461 1.00 11.86 ? 215 ASP A CG 1 ATOM 1563 O OD1 . ASP A 1 231 ? 35.028 -26.253 12.198 1.00 14.96 ? 215 ASP A OD1 1 ATOM 1564 O OD2 . ASP A 1 231 ? 34.738 -28.261 12.997 1.00 12.54 ? 215 ASP A OD2 1 ATOM 1565 N N . LEU A 1 232 ? 29.954 -25.242 11.217 1.00 9.98 ? 216 LEU A N 1 ATOM 1566 C CA . LEU A 1 232 ? 28.715 -25.271 10.459 1.00 12.59 ? 216 LEU A CA 1 ATOM 1567 C C . LEU A 1 232 ? 28.987 -24.781 9.041 1.00 15.18 ? 216 LEU A C 1 ATOM 1568 O O . LEU A 1 232 ? 29.738 -23.831 8.845 1.00 18.58 ? 216 LEU A O 1 ATOM 1569 C CB . LEU A 1 232 ? 27.638 -24.410 11.114 1.00 13.58 ? 216 LEU A CB 1 ATOM 1570 C CG . LEU A 1 232 ? 26.927 -24.953 12.354 1.00 10.04 ? 216 LEU A CG 1 ATOM 1571 C CD1 . LEU A 1 232 ? 26.040 -23.887 12.938 1.00 9.24 ? 216 LEU A CD1 1 ATOM 1572 C CD2 . LEU A 1 232 ? 26.098 -26.170 12.040 1.00 11.46 ? 216 LEU A CD2 1 ATOM 1573 N N . PRO A 1 233 ? 28.388 -25.449 8.044 1.00 14.75 ? 217 PRO A N 1 ATOM 1574 C CA . PRO A 1 233 ? 28.594 -25.096 6.642 1.00 15.49 ? 217 PRO A CA 1 ATOM 1575 C C . PRO A 1 233 ? 27.532 -24.125 6.090 1.00 11.91 ? 217 PRO A C 1 ATOM 1576 O O . PRO A 1 233 ? 26.745 -24.476 5.226 1.00 12.91 ? 217 PRO A O 1 ATOM 1577 C CB . PRO A 1 233 ? 28.528 -26.456 5.955 1.00 18.43 ? 217 PRO A CB 1 ATOM 1578 C CG . PRO A 1 233 ? 27.552 -27.203 6.739 1.00 13.26 ? 217 PRO A CG 1 ATOM 1579 C CD . PRO A 1 233 ? 27.689 -26.739 8.166 1.00 12.57 ? 217 PRO A CD 1 ATOM 1580 N N . LEU A 1 234 ? 27.535 -22.904 6.596 1.00 11.30 ? 218 LEU A N 1 ATOM 1581 C CA . LEU A 1 234 ? 26.657 -21.858 6.124 1.00 10.31 ? 218 LEU A CA 1 ATOM 1582 C C . LEU A 1 234 ? 27.522 -20.634 5.888 1.00 10.28 ? 218 LEU A C 1 ATOM 1583 O O . LEU A 1 234 ? 28.594 -20.566 6.473 1.00 8.32 ? 218 LEU A O 1 ATOM 1584 C CB . LEU A 1 234 ? 25.612 -21.561 7.191 1.00 10.44 ? 218 LEU A CB 1 ATOM 1585 C CG . LEU A 1 234 ? 24.566 -22.647 7.451 1.00 11.32 ? 218 LEU A CG 1 ATOM 1586 C CD1 . LEU A 1 234 ? 23.883 -22.442 8.791 1.00 13.58 ? 218 LEU A CD1 1 ATOM 1587 C CD2 . LEU A 1 234 ? 23.560 -22.616 6.329 1.00 8.98 ? 218 LEU A CD2 1 ATOM 1588 N N . PRO A 1 235 ? 27.069 -19.669 5.033 1.00 11.85 ? 219 PRO A N 1 ATOM 1589 C CA . PRO A 1 235 ? 27.787 -18.383 4.953 1.00 10.85 ? 219 PRO A CA 1 ATOM 1590 C C . PRO A 1 235 ? 27.863 -17.698 6.321 1.00 9.92 ? 219 PRO A C 1 ATOM 1591 O O . PRO A 1 235 ? 26.898 -17.706 7.060 1.00 9.68 ? 219 PRO A O 1 ATOM 1592 C CB . PRO A 1 235 ? 26.954 -17.560 3.948 1.00 9.82 ? 219 PRO A CB 1 ATOM 1593 C CG . PRO A 1 235 ? 26.186 -18.573 3.165 1.00 9.39 ? 219 PRO A CG 1 ATOM 1594 C CD . PRO A 1 235 ? 25.909 -19.701 4.112 1.00 8.26 ? 219 PRO A CD 1 ATOM 1595 N N . TRP A 1 236 ? 29.012 -17.125 6.647 1.00 10.65 ? 220 TRP A N 1 ATOM 1596 C CA . TRP A 1 236 ? 29.243 -16.600 7.975 1.00 10.46 ? 220 TRP A CA 1 ATOM 1597 C C . TRP A 1 236 ? 29.951 -15.278 7.929 1.00 11.60 ? 220 TRP A C 1 ATOM 1598 O O . TRP A 1 236 ? 30.600 -14.943 6.950 1.00 14.22 ? 220 TRP A O 1 ATOM 1599 C CB . TRP A 1 236 ? 30.084 -17.571 8.799 1.00 10.04 ? 220 TRP A CB 1 ATOM 1600 C CG . TRP A 1 236 ? 31.493 -17.748 8.331 1.00 12.95 ? 220 TRP A CG 1 ATOM 1601 C CD1 . TRP A 1 236 ? 31.960 -18.709 7.472 1.00 12.96 ? 220 TRP A CD1 1 ATOM 1602 C CD2 . TRP A 1 236 ? 32.634 -16.959 8.705 1.00 12.11 ? 220 TRP A CD2 1 ATOM 1603 N NE1 . TRP A 1 236 ? 33.313 -18.563 7.290 1.00 14.78 ? 220 TRP A NE1 1 ATOM 1604 C CE2 . TRP A 1 236 ? 33.747 -17.496 8.041 1.00 16.24 ? 220 TRP A CE2 1 ATOM 1605 C CE3 . TRP A 1 236 ? 32.815 -15.850 9.543 1.00 10.47 ? 220 TRP A CE3 1 ATOM 1606 C CZ2 . TRP A 1 236 ? 35.027 -16.960 8.188 1.00 17.37 ? 220 TRP A CZ2 1 ATOM 1607 C CZ3 . TRP A 1 236 ? 34.071 -15.327 9.685 1.00 11.47 ? 220 TRP A CZ3 1 ATOM 1608 C CH2 . TRP A 1 236 ? 35.166 -15.882 9.015 1.00 13.18 ? 220 TRP A CH2 1 ATOM 1609 N N . THR A 1 237 ? 29.827 -14.534 9.017 1.00 12.77 ? 221 THR A N 1 ATOM 1610 C CA . THR A 1 237 ? 30.499 -13.254 9.162 1.00 13.98 ? 221 THR A CA 1 ATOM 1611 C C . THR A 1 237 ? 30.921 -13.079 10.628 1.00 11.07 ? 221 THR A C 1 ATOM 1612 O O . THR A 1 237 ? 30.229 -13.521 11.532 1.00 10.59 ? 221 THR A O 1 ATOM 1613 C CB . THR A 1 237 ? 29.605 -12.074 8.633 1.00 14.26 ? 221 THR A CB 1 ATOM 1614 O OG1 . THR A 1 237 ? 30.402 -10.912 8.428 1.00 18.13 ? 221 THR A OG1 1 ATOM 1615 C CG2 . THR A 1 237 ? 28.472 -11.738 9.569 1.00 14.53 ? 221 THR A CG2 1 ATOM 1616 N N . SER A 1 238 ? 32.066 -12.444 10.843 1.00 10.85 ? 222 SER A N 1 ATOM 1617 C CA . SER A 1 238 ? 32.590 -12.237 12.178 1.00 11.03 ? 222 SER A CA 1 ATOM 1618 C C . SER A 1 238 ? 31.596 -11.450 12.989 1.00 10.95 ? 222 SER A C 1 ATOM 1619 O O . SER A 1 238 ? 30.828 -10.667 12.435 1.00 10.71 ? 222 SER A O 1 ATOM 1620 C CB . SER A 1 238 ? 33.920 -11.482 12.116 1.00 11.04 ? 222 SER A CB 1 ATOM 1621 O OG . SER A 1 238 ? 34.511 -11.364 13.384 1.00 11.85 ? 222 SER A OG 1 ATOM 1622 N N . GLY A 1 239 ? 31.601 -11.675 14.298 1.00 7.52 ? 223 GLY A N 1 ATOM 1623 C CA . GLY A 1 239 ? 30.821 -10.869 15.210 1.00 9.44 ? 223 GLY A CA 1 ATOM 1624 C C . GLY A 1 239 ? 31.370 -9.463 15.403 1.00 9.24 ? 223 GLY A C 1 ATOM 1625 O O . GLY A 1 239 ? 30.702 -8.598 15.989 1.00 13.83 ? 223 GLY A O 1 ATOM 1626 N N . ALA A 1 240 ? 32.576 -9.230 14.892 1.00 9.72 ? 224 ALA A N 1 ATOM 1627 C CA . ALA A 1 240 ? 33.281 -7.963 15.050 1.00 10.49 ? 224 ALA A CA 1 ATOM 1628 C C . ALA A 1 240 ? 32.486 -6.753 14.544 1.00 12.86 ? 224 ALA A C 1 ATOM 1629 O O . ALA A 1 240 ? 31.667 -6.861 13.639 1.00 12.59 ? 224 ALA A O 1 ATOM 1630 C CB . ALA A 1 240 ? 34.634 -8.039 14.363 1.00 9.01 ? 224 ALA A CB 1 ATOM 1631 N N . SER A 1 241 ? 32.759 -5.601 15.152 1.00 16.27 ? 225 SER A N 1 ATOM 1632 C CA . SER A 1 241 ? 32.059 -4.337 14.882 1.00 14.34 ? 225 SER A CA 1 ATOM 1633 C C . SER A 1 241 ? 32.268 -3.811 13.459 1.00 11.50 ? 225 SER A C 1 ATOM 1634 O O . SER A 1 241 ? 33.381 -3.584 13.039 1.00 12.88 ? 225 SER A O 1 ATOM 1635 C CB . SER A 1 241 ? 32.557 -3.290 15.883 1.00 11.67 ? 225 SER A CB 1 ATOM 1636 O OG . SER A 1 241 ? 31.514 -2.511 16.367 1.00 21.57 ? 225 SER A OG 1 ATOM 1637 N N . THR A 1 242 ? 31.182 -3.604 12.726 1.00 14.38 ? 226 THR A N 1 ATOM 1638 C CA . THR A 1 242 ? 31.281 -3.108 11.362 1.00 19.95 ? 226 THR A CA 1 ATOM 1639 C C . THR A 1 242 ? 30.095 -2.281 10.898 1.00 20.31 ? 226 THR A C 1 ATOM 1640 O O . THR A 1 242 ? 29.003 -2.315 11.468 1.00 20.50 ? 226 THR A O 1 ATOM 1641 C CB . THR A 1 242 ? 31.473 -4.247 10.343 1.00 19.88 ? 226 THR A CB 1 ATOM 1642 O OG1 . THR A 1 242 ? 31.684 -3.685 9.043 1.00 30.15 ? 226 THR A OG1 1 ATOM 1643 C CG2 . THR A 1 242 ? 30.272 -5.163 10.304 1.00 14.63 ? 226 THR A CG2 1 ATOM 1644 N N . SER A 1 243 ? 30.342 -1.538 9.834 1.00 21.45 ? 227 SER A N 1 ATOM 1645 C CA . SER A 1 243 ? 29.313 -0.770 9.166 1.00 28.64 ? 227 SER A CA 1 ATOM 1646 C C . SER A 1 243 ? 28.817 -1.511 7.928 1.00 25.64 ? 227 SER A C 1 ATOM 1647 O O . SER A 1 243 ? 27.704 -1.300 7.453 1.00 29.21 ? 227 SER A O 1 ATOM 1648 C CB . SER A 1 243 ? 29.878 0.578 8.746 1.00 30.58 ? 227 SER A CB 1 ATOM 1649 O OG . SER A 1 243 ? 30.971 0.435 7.855 1.00 29.67 ? 227 SER A OG 1 ATOM 1650 N N . GLN A 1 244 ? 29.668 -2.384 7.415 1.00 28.53 ? 228 GLN A N 1 ATOM 1651 C CA . GLN A 1 244 ? 29.436 -3.041 6.141 1.00 32.48 ? 228 GLN A CA 1 ATOM 1652 C C . GLN A 1 244 ? 29.469 -4.555 6.301 1.00 28.25 ? 228 GLN A C 1 ATOM 1653 O O . GLN A 1 244 ? 30.536 -5.159 6.217 1.00 34.20 ? 228 GLN A O 1 ATOM 1654 C CB . GLN A 1 244 ? 30.506 -2.597 5.141 1.00 40.09 ? 228 GLN A CB 1 ATOM 1655 C CG . GLN A 1 244 ? 30.000 -2.373 3.718 1.00 44.87 ? 228 GLN A CG 1 ATOM 1656 C CD . GLN A 1 244 ? 30.858 -1.364 2.945 1.00 50.89 ? 228 GLN A CD 1 ATOM 1657 O OE1 . GLN A 1 244 ? 32.048 -1.167 3.240 1.00 47.96 ? 228 GLN A OE1 1 ATOM 1658 N NE2 . GLN A 1 244 ? 30.247 -0.708 1.962 1.00 44.20 ? 228 GLN A NE2 1 ATOM 1659 N N . GLU A 1 245 ? 28.290 -5.142 6.538 1.00 23.71 ? 229 GLU A N 1 ATOM 1660 C CA . GLU A 1 245 ? 28.080 -6.604 6.628 1.00 28.43 ? 229 GLU A CA 1 ATOM 1661 C C . GLU A 1 245 ? 28.610 -7.371 5.392 1.00 29.53 ? 229 GLU A C 1 ATOM 1662 O O . GLU A 1 245 ? 28.110 -7.187 4.286 1.00 33.28 ? 229 GLU A O 1 ATOM 1663 C CB . GLU A 1 245 ? 26.568 -6.876 6.824 1.00 21.44 ? 229 GLU A CB 1 ATOM 1664 C CG . GLU A 1 245 ? 26.186 -8.313 7.150 1.00 19.69 ? 229 GLU A CG 1 ATOM 1665 C CD . GLU A 1 245 ? 24.827 -8.459 7.851 1.00 22.02 ? 229 GLU A CD 1 ATOM 1666 O OE1 . GLU A 1 245 ? 24.823 -8.832 9.048 1.00 23.35 ? 229 GLU A OE1 1 ATOM 1667 O OE2 . GLU A 1 245 ? 23.762 -8.236 7.208 1.00 22.74 ? 229 GLU A OE2 1 ATOM 1668 N N . THR A 1 246 ? 29.601 -8.240 5.585 1.00 26.58 ? 230 THR A N 1 ATOM 1669 C CA . THR A 1 246 ? 30.272 -8.925 4.472 1.00 27.55 ? 230 THR A CA 1 ATOM 1670 C C . THR A 1 246 ? 30.438 -10.424 4.723 1.00 23.50 ? 230 THR A C 1 ATOM 1671 O O . THR A 1 246 ? 31.154 -10.848 5.651 1.00 22.69 ? 230 THR A O 1 ATOM 1672 C CB . THR A 1 246 ? 31.663 -8.307 4.211 1.00 28.04 ? 230 THR A CB 1 ATOM 1673 O OG1 . THR A 1 246 ? 32.519 -9.259 3.565 1.00 29.11 ? 230 THR A OG1 1 ATOM 1674 C CG2 . THR A 1 246 ? 32.299 -7.887 5.528 1.00 35.47 ? 230 THR A CG2 1 ATOM 1675 N N . TRP A 1 247 ? 29.792 -11.218 3.871 1.00 17.67 ? 231 TRP A N 1 ATOM 1676 C CA . TRP A 1 247 ? 29.694 -12.658 4.086 1.00 15.34 ? 231 TRP A CA 1 ATOM 1677 C C . TRP A 1 247 ? 30.837 -13.432 3.478 1.00 17.54 ? 231 TRP A C 1 ATOM 1678 O O . TRP A 1 247 ? 31.413 -13.040 2.469 1.00 20.89 ? 231 TRP A O 1 ATOM 1679 C CB . TRP A 1 247 ? 28.356 -13.194 3.568 1.00 11.08 ? 231 TRP A CB 1 ATOM 1680 C CG . TRP A 1 247 ? 27.218 -12.649 4.360 1.00 13.09 ? 231 TRP A CG 1 ATOM 1681 C CD1 . TRP A 1 247 ? 26.471 -11.552 4.070 1.00 13.00 ? 231 TRP A CD1 1 ATOM 1682 C CD2 . TRP A 1 247 ? 26.723 -13.145 5.604 1.00 10.68 ? 231 TRP A CD2 1 ATOM 1683 N NE1 . TRP A 1 247 ? 25.534 -11.345 5.044 1.00 13.83 ? 231 TRP A NE1 1 ATOM 1684 C CE2 . TRP A 1 247 ? 25.675 -12.312 6.000 1.00 10.45 ? 231 TRP A CE2 1 ATOM 1685 C CE3 . TRP A 1 247 ? 27.071 -14.230 6.410 1.00 9.30 ? 231 TRP A CE3 1 ATOM 1686 C CZ2 . TRP A 1 247 ? 24.958 -12.522 7.163 1.00 14.20 ? 231 TRP A CZ2 1 ATOM 1687 C CZ3 . TRP A 1 247 ? 26.367 -14.438 7.552 1.00 9.85 ? 231 TRP A CZ3 1 ATOM 1688 C CH2 . TRP A 1 247 ? 25.323 -13.592 7.931 1.00 13.89 ? 231 TRP A CH2 1 ATOM 1689 N N . ASN A 1 248 ? 31.163 -14.533 4.133 1.00 14.69 ? 232 ASN A N 1 ATOM 1690 C CA . ASN A 1 248 ? 32.172 -15.448 3.669 1.00 13.06 ? 232 ASN A CA 1 ATOM 1691 C C . ASN A 1 248 ? 31.437 -16.706 3.291 1.00 12.46 ? 232 ASN A C 1 ATOM 1692 O O . ASN A 1 248 ? 30.447 -17.025 3.915 1.00 11.95 ? 232 ASN A O 1 ATOM 1693 C CB . ASN A 1 248 ? 33.173 -15.735 4.785 1.00 12.20 ? 232 ASN A CB 1 ATOM 1694 C CG . ASN A 1 248 ? 33.831 -14.476 5.331 1.00 16.42 ? 232 ASN A CG 1 ATOM 1695 O OD1 . ASN A 1 248 ? 34.623 -13.830 4.655 1.00 18.26 ? 232 ASN A OD1 1 ATOM 1696 N ND2 . ASN A 1 248 ? 33.515 -14.137 6.574 1.00 14.45 ? 232 ASN A ND2 1 ATOM 1697 N N . ARG A 1 249 ? 31.901 -17.402 2.258 1.00 14.28 ? 233 ARG A N 1 ATOM 1698 C CA . ARG A 1 249 ? 31.316 -18.677 1.833 1.00 13.81 ? 233 ARG A CA 1 ATOM 1699 C C . ARG A 1 249 ? 29.879 -18.544 1.317 1.00 12.98 ? 233 ARG A C 1 ATOM 1700 O O . ARG A 1 249 ? 29.032 -19.371 1.631 1.00 13.67 ? 233 ARG A O 1 ATOM 1701 C CB . ARG A 1 249 ? 31.346 -19.694 2.969 1.00 14.04 ? 233 ARG A CB 1 ATOM 1702 C CG . ARG A 1 249 ? 32.734 -20.015 3.532 1.00 15.81 ? 233 ARG A CG 1 ATOM 1703 C CD . ARG A 1 249 ? 33.697 -20.558 2.491 1.00 19.99 ? 233 ARG A CD 1 ATOM 1704 N NE . ARG A 1 249 ? 33.159 -21.696 1.744 1.00 23.61 ? 233 ARG A NE 1 ATOM 1705 C CZ . ARG A 1 249 ? 32.961 -22.915 2.241 1.00 22.28 ? 233 ARG A CZ 1 ATOM 1706 N NH1 . ARG A 1 249 ? 33.227 -23.189 3.514 1.00 29.83 ? 233 ARG A NH1 1 ATOM 1707 N NH2 . ARG A 1 249 ? 32.474 -23.864 1.453 1.00 27.55 ? 233 ARG A NH2 1 ATOM 1708 N N . GLN A 1 250 ? 29.609 -17.498 0.536 1.00 16.37 ? 234 GLN A N 1 ATOM 1709 C CA . GLN A 1 250 ? 28.281 -17.277 -0.056 1.00 15.92 ? 234 GLN A CA 1 ATOM 1710 C C . GLN A 1 250 ? 27.876 -18.448 -0.949 1.00 16.08 ? 234 GLN A C 1 ATOM 1711 O O . GLN A 1 250 ? 26.698 -18.751 -1.104 1.00 16.88 ? 234 GLN A O 1 ATOM 1712 C CB . GLN A 1 250 ? 28.259 -15.969 -0.865 1.00 16.06 ? 234 GLN A CB 1 ATOM 1713 C CG . GLN A 1 250 ? 28.385 -14.675 -0.041 1.00 14.65 ? 234 GLN A CG 1 ATOM 1714 C CD . GLN A 1 250 ? 29.496 -13.782 -0.534 1.00 18.34 ? 234 GLN A CD 1 ATOM 1715 O OE1 . GLN A 1 250 ? 30.654 -13.966 -0.165 1.00 25.09 ? 234 GLN A OE1 1 ATOM 1716 N NE2 . GLN A 1 250 ? 29.163 -12.830 -1.396 1.00 18.93 ? 234 GLN A NE2 1 ATOM 1717 N N . ASP A 1 251 ? 28.871 -19.103 -1.535 1.00 19.50 ? 235 ASP A N 1 ATOM 1718 C CA . ASP A 1 251 ? 28.625 -20.227 -2.420 1.00 19.68 ? 235 ASP A CA 1 ATOM 1719 C C . ASP A 1 251 ? 27.724 -21.253 -1.759 1.00 18.99 ? 235 ASP A C 1 ATOM 1720 O O . ASP A 1 251 ? 27.019 -21.986 -2.435 1.00 24.92 ? 235 ASP A O 1 ATOM 1721 C CB . ASP A 1 251 ? 29.932 -20.912 -2.872 1.00 17.49 ? 235 ASP A CB 1 ATOM 1722 C CG . ASP A 1 251 ? 30.942 -21.091 -1.750 1.00 21.49 ? 235 ASP A CG 1 ATOM 1723 O OD1 . ASP A 1 251 ? 31.289 -20.082 -1.098 1.00 21.95 ? 235 ASP A OD1 1 ATOM 1724 O OD2 . ASP A 1 251 ? 31.426 -22.233 -1.547 1.00 20.96 ? 235 ASP A OD2 1 ATOM 1725 N N . LEU A 1 252 ? 27.746 -21.317 -0.437 1.00 19.25 ? 236 LEU A N 1 ATOM 1726 C CA . LEU A 1 252 ? 27.012 -22.351 0.268 1.00 16.16 ? 236 LEU A CA 1 ATOM 1727 C C . LEU A 1 252 ? 25.487 -22.212 0.108 1.00 15.53 ? 236 LEU A C 1 ATOM 1728 O O . LEU A 1 252 ? 24.753 -23.145 0.404 1.00 20.72 ? 236 LEU A O 1 ATOM 1729 C CB . LEU A 1 252 ? 27.414 -22.374 1.753 1.00 16.11 ? 236 LEU A CB 1 ATOM 1730 C CG . LEU A 1 252 ? 28.894 -22.608 2.081 1.00 17.20 ? 236 LEU A CG 1 ATOM 1731 C CD1 . LEU A 1 252 ? 29.162 -22.503 3.578 1.00 11.88 ? 236 LEU A CD1 1 ATOM 1732 C CD2 . LEU A 1 252 ? 29.326 -23.958 1.596 1.00 19.78 ? 236 LEU A CD2 1 ATOM 1733 N N . LEU A 1 253 ? 25.016 -21.057 -0.352 1.00 15.76 ? 237 LEU A N 1 ATOM 1734 C CA . LEU A 1 253 ? 23.587 -20.832 -0.552 1.00 15.86 ? 237 LEU A CA 1 ATOM 1735 C C . LEU A 1 253 ? 23.238 -20.397 -1.975 1.00 16.00 ? 237 LEU A C 1 ATOM 1736 O O . LEU A 1 253 ? 22.071 -20.257 -2.306 1.00 17.86 ? 237 LEU A O 1 ATOM 1737 C CB . LEU A 1 253 ? 23.073 -19.763 0.410 1.00 13.85 ? 237 LEU A CB 1 ATOM 1738 C CG . LEU A 1 253 ? 23.021 -20.111 1.892 1.00 12.45 ? 237 LEU A CG 1 ATOM 1739 C CD1 . LEU A 1 253 ? 22.363 -18.977 2.615 1.00 12.35 ? 237 LEU A CD1 1 ATOM 1740 C CD2 . LEU A 1 253 ? 22.287 -21.395 2.127 1.00 14.87 ? 237 LEU A CD2 1 ATOM 1741 N N . VAL A 1 254 ? 24.242 -20.180 -2.807 1.00 16.41 ? 238 VAL A N 1 ATOM 1742 C CA . VAL A 1 254 ? 24.027 -19.654 -4.146 1.00 13.70 ? 238 VAL A CA 1 ATOM 1743 C C . VAL A 1 254 ? 24.395 -20.659 -5.220 1.00 17.16 ? 238 VAL A C 1 ATOM 1744 O O . VAL A 1 254 ? 25.435 -21.311 -5.149 1.00 14.57 ? 238 VAL A O 1 ATOM 1745 C CB . VAL A 1 254 ? 24.885 -18.427 -4.368 1.00 14.03 ? 238 VAL A CB 1 ATOM 1746 C CG1 . VAL A 1 254 ? 24.747 -17.944 -5.779 1.00 14.12 ? 238 VAL A CG1 1 ATOM 1747 C CG2 . VAL A 1 254 ? 24.499 -17.337 -3.391 1.00 16.74 ? 238 VAL A CG2 1 ATOM 1748 N N . THR A 1 255 ? 23.553 -20.760 -6.239 1.00 18.48 ? 239 THR A N 1 ATOM 1749 C CA . THR A 1 255 ? 23.790 -21.703 -7.323 1.00 15.97 ? 239 THR A CA 1 ATOM 1750 C C . THR A 1 255 ? 23.748 -20.970 -8.662 1.00 13.07 ? 239 THR A C 1 ATOM 1751 O O . THR A 1 255 ? 22.730 -20.426 -9.040 1.00 15.39 ? 239 THR A O 1 ATOM 1752 C CB . THR A 1 255 ? 22.757 -22.861 -7.287 1.00 19.39 ? 239 THR A CB 1 ATOM 1753 O OG1 . THR A 1 255 ? 22.974 -23.682 -6.127 1.00 19.11 ? 239 THR A OG1 1 ATOM 1754 C CG2 . THR A 1 255 ? 22.866 -23.734 -8.519 1.00 20.54 ? 239 THR A CG2 1 ATOM 1755 N N . PHE A 1 256 ? 24.890 -20.921 -9.340 1.00 16.40 ? 240 PHE A N 1 ATOM 1756 C CA . PHE A 1 256 ? 24.982 -20.398 -10.695 1.00 12.68 ? 240 PHE A CA 1 ATOM 1757 C C . PHE A 1 256 ? 24.541 -21.498 -11.624 1.00 13.05 ? 240 PHE A C 1 ATOM 1758 O O . PHE A 1 256 ? 25.128 -22.576 -11.635 1.00 17.58 ? 240 PHE A O 1 ATOM 1759 C CB . PHE A 1 256 ? 26.427 -20.046 -11.045 1.00 15.44 ? 240 PHE A CB 1 ATOM 1760 C CG . PHE A 1 256 ? 26.913 -18.759 -10.449 1.00 16.55 ? 240 PHE A CG 1 ATOM 1761 C CD1 . PHE A 1 256 ? 27.122 -18.634 -9.088 1.00 17.85 ? 240 PHE A CD1 1 ATOM 1762 C CD2 . PHE A 1 256 ? 27.183 -17.675 -11.258 1.00 18.62 ? 240 PHE A CD2 1 ATOM 1763 C CE1 . PHE A 1 256 ? 27.580 -17.446 -8.547 1.00 14.91 ? 240 PHE A CE1 1 ATOM 1764 C CE2 . PHE A 1 256 ? 27.640 -16.490 -10.716 1.00 14.89 ? 240 PHE A CE2 1 ATOM 1765 C CZ . PHE A 1 256 ? 27.830 -16.376 -9.365 1.00 15.61 ? 240 PHE A CZ 1 ATOM 1766 N N . LYS A 1 257 ? 23.520 -21.231 -12.422 1.00 15.42 ? 241 LYS A N 1 ATOM 1767 C CA . LYS A 1 257 ? 23.004 -22.221 -13.359 1.00 14.65 ? 241 LYS A CA 1 ATOM 1768 C C . LYS A 1 257 ? 23.900 -22.285 -14.593 1.00 12.39 ? 241 LYS A C 1 ATOM 1769 O O . LYS A 1 257 ? 24.827 -21.522 -14.697 1.00 13.41 ? 241 LYS A O 1 ATOM 1770 C CB . LYS A 1 257 ? 21.565 -21.866 -13.745 1.00 15.18 ? 241 LYS A CB 1 ATOM 1771 C CG . LYS A 1 257 ? 20.606 -21.678 -12.554 1.00 14.40 ? 241 LYS A CG 1 ATOM 1772 C CD . LYS A 1 257 ? 20.540 -22.892 -11.653 1.00 19.70 ? 241 LYS A CD 1 ATOM 1773 C CE . LYS A 1 257 ? 19.927 -24.109 -12.324 1.00 25.02 ? 241 LYS A CE 1 ATOM 1774 N NZ . LYS A 1 257 ? 20.208 -25.398 -11.593 1.00 29.95 ? 241 LYS A NZ 1 ATOM 1775 N N . THR A 1 258 ? 23.641 -23.201 -15.512 1.00 14.86 ? 242 THR A N 1 ATOM 1776 C CA A THR A 1 258 ? 24.449 -23.297 -16.723 0.52 16.89 ? 242 THR A CA 1 ATOM 1777 C CA B THR A 1 258 ? 24.432 -23.309 -16.736 0.48 16.89 ? 242 THR A CA 1 ATOM 1778 C C . THR A 1 258 ? 24.373 -21.990 -17.495 1.00 14.48 ? 242 THR A C 1 ATOM 1779 O O . THR A 1 258 ? 23.297 -21.420 -17.680 1.00 16.72 ? 242 THR A O 1 ATOM 1780 C CB A THR A 1 258 ? 23.996 -24.458 -17.632 0.52 18.72 ? 242 THR A CB 1 ATOM 1781 C CB B THR A 1 258 ? 23.906 -24.427 -17.654 0.48 18.72 ? 242 THR A CB 1 ATOM 1782 O OG1 A THR A 1 258 ? 22.590 -24.360 -17.893 0.52 19.39 ? 242 THR A OG1 1 ATOM 1783 O OG1 B THR A 1 258 ? 23.921 -25.678 -16.956 0.48 19.50 ? 242 THR A OG1 1 ATOM 1784 C CG2 A THR A 1 258 ? 24.297 -25.788 -16.978 0.52 19.72 ? 242 THR A CG2 1 ATOM 1785 C CG2 B THR A 1 258 ? 24.764 -24.541 -18.910 0.48 17.57 ? 242 THR A CG2 1 ATOM 1786 N N . ALA A 1 259 ? 25.526 -21.510 -17.937 1.00 12.95 ? 243 ALA A N 1 ATOM 1787 C CA . ALA A 1 259 ? 25.595 -20.235 -18.614 1.00 12.78 ? 243 ALA A CA 1 ATOM 1788 C C . ALA A 1 259 ? 25.240 -20.362 -20.084 1.00 14.87 ? 243 ALA A C 1 ATOM 1789 O O . ALA A 1 259 ? 25.455 -21.402 -20.701 1.00 16.82 ? 243 ALA A O 1 ATOM 1790 C CB . ALA A 1 259 ? 26.960 -19.618 -18.445 1.00 11.85 ? 243 ALA A CB 1 ATOM 1791 N N . HIS A 1 260 ? 24.664 -19.294 -20.620 1.00 17.60 ? 244 HIS A N 1 ATOM 1792 C CA . HIS A 1 260 ? 24.393 -19.170 -22.040 1.00 13.43 ? 244 HIS A CA 1 ATOM 1793 C C . HIS A 1 260 ? 25.323 -18.127 -22.622 1.00 13.60 ? 244 HIS A C 1 ATOM 1794 O O . HIS A 1 260 ? 26.099 -17.533 -21.905 1.00 14.07 ? 244 HIS A O 1 ATOM 1795 C CB . HIS A 1 260 ? 22.928 -18.805 -22.243 1.00 17.04 ? 244 HIS A CB 1 ATOM 1796 C CG . HIS A 1 260 ? 21.992 -19.825 -21.675 1.00 21.85 ? 244 HIS A CG 1 ATOM 1797 N ND1 . HIS A 1 260 ? 21.537 -19.784 -20.378 1.00 23.81 ? 244 HIS A ND1 1 ATOM 1798 C CD2 . HIS A 1 260 ? 21.474 -20.954 -22.223 1.00 23.12 ? 244 HIS A CD2 1 ATOM 1799 C CE1 . HIS A 1 260 ? 20.746 -20.822 -20.157 1.00 25.17 ? 244 HIS A CE1 1 ATOM 1800 N NE2 . HIS A 1 260 ? 20.696 -21.545 -21.260 1.00 28.95 ? 244 HIS A NE2 1 ATOM 1801 N N . ALA A 1 261 ? 25.250 -17.896 -23.922 1.00 15.57 ? 245 ALA A N 1 ATOM 1802 C CA . ALA A 1 261 ? 26.211 -17.032 -24.586 1.00 13.57 ? 245 ALA A CA 1 ATOM 1803 C C . ALA A 1 261 ? 26.388 -15.703 -23.881 1.00 12.46 ? 245 ALA A C 1 ATOM 1804 O O . ALA A 1 261 ? 27.507 -15.221 -23.722 1.00 13.97 ? 245 ALA A O 1 ATOM 1805 C CB . ALA A 1 261 ? 25.786 -16.784 -26.007 1.00 10.48 ? 245 ALA A CB 1 ATOM 1806 N N . LYS A 1 262 ? 25.279 -15.104 -23.484 1.00 12.39 ? 246 LYS A N 1 ATOM 1807 C CA . LYS A 1 262 ? 25.291 -13.735 -23.025 1.00 13.01 ? 246 LYS A CA 1 ATOM 1808 C C . LYS A 1 262 ? 24.641 -13.575 -21.654 1.00 13.25 ? 246 LYS A C 1 ATOM 1809 O O . LYS A 1 262 ? 24.595 -12.476 -21.103 1.00 14.15 ? 246 LYS A O 1 ATOM 1810 C CB . LYS A 1 262 ? 24.583 -12.863 -24.056 1.00 11.76 ? 246 LYS A CB 1 ATOM 1811 C CG . LYS A 1 262 ? 25.292 -12.855 -25.399 1.00 15.60 ? 246 LYS A CG 1 ATOM 1812 C CD . LYS A 1 262 ? 24.396 -12.426 -26.535 1.00 14.94 ? 246 LYS A CD 1 ATOM 1813 C CE . LYS A 1 262 ? 25.204 -12.140 -27.783 1.00 18.48 ? 246 LYS A CE 1 ATOM 1814 N NZ . LYS A 1 262 ? 24.395 -11.492 -28.839 1.00 16.80 ? 246 LYS A NZ 1 ATOM 1815 N N . LYS A 1 263 ? 24.146 -14.675 -21.098 1.00 13.07 ? 247 LYS A N 1 ATOM 1816 C CA . LYS A 1 263 ? 23.380 -14.596 -19.869 1.00 10.10 ? 247 LYS A CA 1 ATOM 1817 C C . LYS A 1 263 ? 23.521 -15.861 -19.047 1.00 12.27 ? 247 LYS A C 1 ATOM 1818 O O . LYS A 1 263 ? 23.867 -16.910 -19.567 1.00 11.14 ? 247 LYS A O 1 ATOM 1819 C CB . LYS A 1 263 ? 21.921 -14.322 -20.197 1.00 11.64 ? 247 LYS A CB 1 ATOM 1820 C CG . LYS A 1 263 ? 21.195 -15.471 -20.823 1.00 15.92 ? 247 LYS A CG 1 ATOM 1821 C CD . LYS A 1 263 ? 19.743 -15.068 -21.126 1.00 26.80 ? 247 LYS A CD 1 ATOM 1822 C CE . LYS A 1 263 ? 18.821 -16.274 -21.410 1.00 28.80 ? 247 LYS A CE 1 ATOM 1823 N NZ . LYS A 1 263 ? 17.409 -15.861 -21.748 1.00 32.92 ? 247 LYS A NZ 1 ATOM 1824 N N . GLN A 1 264 ? 23.259 -15.737 -17.755 1.00 13.25 ? 248 GLN A N 1 ATOM 1825 C CA . GLN A 1 264 ? 23.386 -16.841 -16.832 1.00 14.46 ? 248 GLN A CA 1 ATOM 1826 C C . GLN A 1 264 ? 22.550 -16.546 -15.619 1.00 10.61 ? 248 GLN A C 1 ATOM 1827 O O . GLN A 1 264 ? 22.671 -15.486 -15.016 1.00 10.18 ? 248 GLN A O 1 ATOM 1828 C CB . GLN A 1 264 ? 24.841 -17.022 -16.405 1.00 10.82 ? 248 GLN A CB 1 ATOM 1829 C CG . GLN A 1 264 ? 25.077 -18.176 -15.434 1.00 8.51 ? 248 GLN A CG 1 ATOM 1830 C CD . GLN A 1 264 ? 26.544 -18.392 -15.131 1.00 11.21 ? 248 GLN A CD 1 ATOM 1831 O OE1 . GLN A 1 264 ? 27.338 -17.468 -15.205 1.00 13.05 ? 248 GLN A OE1 1 ATOM 1832 N NE2 . GLN A 1 264 ? 26.908 -19.609 -14.776 1.00 10.06 ? 248 GLN A NE2 1 ATOM 1833 N N . GLU A 1 265 ? 21.699 -17.491 -15.256 1.00 11.44 ? 249 GLU A N 1 ATOM 1834 C CA . GLU A 1 265 ? 20.882 -17.324 -14.067 1.00 15.70 ? 249 GLU A CA 1 ATOM 1835 C C . GLU A 1 265 ? 21.642 -17.731 -12.819 1.00 12.86 ? 249 GLU A C 1 ATOM 1836 O O . GLU A 1 265 ? 22.422 -18.689 -12.823 1.00 10.74 ? 249 GLU A O 1 ATOM 1837 C CB . GLU A 1 265 ? 19.585 -18.118 -14.172 1.00 16.50 ? 249 GLU A CB 1 ATOM 1838 C CG . GLU A 1 265 ? 18.607 -17.828 -13.037 1.00 20.42 ? 249 GLU A CG 1 ATOM 1839 C CD . GLU A 1 265 ? 17.287 -18.571 -13.192 1.00 26.77 ? 249 GLU A CD 1 ATOM 1840 O OE1 . GLU A 1 265 ? 17.302 -19.661 -13.799 1.00 27.57 ? 249 GLU A OE1 1 ATOM 1841 O OE2 . GLU A 1 265 ? 16.239 -18.069 -12.711 1.00 35.22 ? 249 GLU A OE2 1 ATOM 1842 N N . VAL A 1 266 ? 21.424 -16.972 -11.756 1.00 11.83 ? 250 VAL A N 1 ATOM 1843 C CA . VAL A 1 266 ? 21.995 -17.288 -10.467 1.00 13.61 ? 250 VAL A CA 1 ATOM 1844 C C . VAL A 1 266 ? 20.834 -17.508 -9.541 1.00 12.92 ? 250 VAL A C 1 ATOM 1845 O O . VAL A 1 266 ? 19.927 -16.697 -9.516 1.00 16.63 ? 250 VAL A O 1 ATOM 1846 C CB . VAL A 1 266 ? 22.864 -16.146 -9.934 1.00 12.82 ? 250 VAL A CB 1 ATOM 1847 C CG1 . VAL A 1 266 ? 23.382 -16.477 -8.543 1.00 13.34 ? 250 VAL A CG1 1 ATOM 1848 C CG2 . VAL A 1 266 ? 24.012 -15.866 -10.895 1.00 13.06 ? 250 VAL A CG2 1 ATOM 1849 N N . VAL A 1 267 ? 20.851 -18.611 -8.797 1.00 14.65 ? 251 VAL A N 1 ATOM 1850 C CA . VAL A 1 267 ? 19.773 -18.918 -7.855 1.00 20.10 ? 251 VAL A CA 1 ATOM 1851 C C . VAL A 1 267 ? 20.246 -19.156 -6.414 1.00 14.96 ? 251 VAL A C 1 ATOM 1852 O O . VAL A 1 267 ? 21.411 -19.405 -6.140 1.00 15.07 ? 251 VAL A O 1 ATOM 1853 C CB . VAL A 1 267 ? 18.950 -20.152 -8.292 1.00 15.89 ? 251 VAL A CB 1 ATOM 1854 C CG1 . VAL A 1 267 ? 18.427 -19.967 -9.680 1.00 18.95 ? 251 VAL A CG1 1 ATOM 1855 C CG2 . VAL A 1 267 ? 19.785 -21.410 -8.198 1.00 18.66 ? 251 VAL A CG2 1 ATOM 1856 N N . VAL A 1 268 ? 19.306 -19.099 -5.491 1.00 17.90 ? 252 VAL A N 1 ATOM 1857 C CA . VAL A 1 268 ? 19.647 -19.223 -4.083 1.00 20.25 ? 252 VAL A CA 1 ATOM 1858 C C . VAL A 1 268 ? 18.893 -20.404 -3.472 1.00 18.17 ? 252 VAL A C 1 ATOM 1859 O O . VAL A 1 268 ? 17.788 -20.727 -3.901 1.00 16.14 ? 252 VAL A O 1 ATOM 1860 C CB . VAL A 1 268 ? 19.415 -17.852 -3.348 1.00 17.40 ? 252 VAL A CB 1 ATOM 1861 C CG1 . VAL A 1 268 ? 17.986 -17.711 -2.880 1.00 17.58 ? 252 VAL A CG1 1 ATOM 1862 C CG2 . VAL A 1 268 ? 20.422 -17.655 -2.221 1.00 18.01 ? 252 VAL A CG2 1 ATOM 1863 N N . LEU A 1 269 ? 19.534 -21.090 -2.531 1.00 16.23 ? 253 LEU A N 1 ATOM 1864 C CA . LEU A 1 269 ? 18.895 -22.156 -1.795 1.00 14.26 ? 253 LEU A CA 1 ATOM 1865 C C . LEU A 1 269 ? 17.744 -21.550 -1.034 1.00 14.49 ? 253 LEU A C 1 ATOM 1866 O O . LEU A 1 269 ? 17.679 -20.339 -0.887 1.00 17.01 ? 253 LEU A O 1 ATOM 1867 C CB . LEU A 1 269 ? 19.877 -22.789 -0.812 1.00 16.73 ? 253 LEU A CB 1 ATOM 1868 C CG . LEU A 1 269 ? 20.961 -23.753 -1.309 1.00 16.38 ? 253 LEU A CG 1 ATOM 1869 C CD1 . LEU A 1 269 ? 20.391 -25.127 -1.538 1.00 29.18 ? 253 LEU A CD1 1 ATOM 1870 C CD2 . LEU A 1 269 ? 21.642 -23.272 -2.568 1.00 25.29 ? 253 LEU A CD2 1 ATOM 1871 N N . GLY A 1 270 ? 16.825 -22.381 -0.556 1.00 17.57 ? 254 GLY A N 1 ATOM 1872 C CA . GLY A 1 270 ? 15.762 -21.889 0.295 1.00 16.67 ? 254 GLY A CA 1 ATOM 1873 C C . GLY A 1 270 ? 16.268 -21.675 1.709 1.00 16.71 ? 254 GLY A C 1 ATOM 1874 O O . GLY A 1 270 ? 17.460 -21.764 1.972 1.00 15.21 ? 254 GLY A O 1 ATOM 1875 N N . SER A 1 271 ? 15.356 -21.391 2.625 1.00 17.87 ? 255 SER A N 1 ATOM 1876 C CA . SER A 1 271 ? 15.722 -21.240 4.029 1.00 17.16 ? 255 SER A CA 1 ATOM 1877 C C . SER A 1 271 ? 16.201 -22.547 4.647 1.00 15.34 ? 255 SER A C 1 ATOM 1878 O O . SER A 1 271 ? 15.689 -23.623 4.366 1.00 12.72 ? 255 SER A O 1 ATOM 1879 C CB . SER A 1 271 ? 14.558 -20.693 4.846 1.00 17.36 ? 255 SER A CB 1 ATOM 1880 O OG . SER A 1 271 ? 14.903 -20.641 6.220 1.00 18.38 ? 255 SER A OG 1 ATOM 1881 N N . GLN A 1 272 ? 17.209 -22.427 5.497 1.00 19.15 ? 256 GLN A N 1 ATOM 1882 C CA . GLN A 1 272 ? 17.808 -23.577 6.145 1.00 18.84 ? 256 GLN A CA 1 ATOM 1883 C C . GLN A 1 272 ? 17.390 -23.634 7.607 1.00 14.93 ? 256 GLN A C 1 ATOM 1884 O O . GLN A 1 272 ? 18.043 -24.305 8.407 1.00 15.60 ? 256 GLN A O 1 ATOM 1885 C CB . GLN A 1 272 ? 19.333 -23.501 6.061 1.00 16.03 ? 256 GLN A CB 1 ATOM 1886 C CG . GLN A 1 272 ? 19.869 -23.485 4.646 1.00 17.58 ? 256 GLN A CG 1 ATOM 1887 C CD . GLN A 1 272 ? 19.480 -24.717 3.869 1.00 17.89 ? 256 GLN A CD 1 ATOM 1888 O OE1 . GLN A 1 272 ? 19.760 -25.841 4.270 1.00 18.34 ? 256 GLN A OE1 1 ATOM 1889 N NE2 . GLN A 1 272 ? 18.813 -24.510 2.759 1.00 14.92 ? 256 GLN A NE2 1 ATOM 1890 N N . GLU A 1 273 ? 16.318 -22.920 7.953 1.00 14.95 ? 257 GLU A N 1 ATOM 1891 C CA . GLU A 1 273 ? 15.794 -22.925 9.318 1.00 17.97 ? 257 GLU A CA 1 ATOM 1892 C C . GLU A 1 273 ? 15.352 -24.326 9.720 1.00 17.75 ? 257 GLU A C 1 ATOM 1893 O O . GLU A 1 273 ? 15.502 -24.712 10.867 1.00 16.17 ? 257 GLU A O 1 ATOM 1894 C CB . GLU A 1 273 ? 14.632 -21.938 9.479 1.00 18.04 ? 257 GLU A CB 1 ATOM 1895 C CG . GLU A 1 273 ? 13.854 -22.103 10.779 1.00 20.71 ? 257 GLU A CG 1 ATOM 1896 C CD . GLU A 1 273 ? 12.693 -21.128 10.917 1.00 29.51 ? 257 GLU A CD 1 ATOM 1897 O OE1 . GLU A 1 273 ? 12.390 -20.418 9.940 1.00 39.46 ? 257 GLU A OE1 1 ATOM 1898 O OE2 . GLU A 1 273 ? 12.072 -21.069 12.003 1.00 34.27 ? 257 GLU A OE2 1 ATOM 1899 N N . GLY A 1 274 ? 14.829 -25.086 8.765 1.00 15.63 ? 258 GLY A N 1 ATOM 1900 C CA . GLY A 1 274 ? 14.361 -26.430 9.022 1.00 15.79 ? 258 GLY A CA 1 ATOM 1901 C C . GLY A 1 274 ? 15.493 -27.409 9.197 1.00 14.67 ? 258 GLY A C 1 ATOM 1902 O O . GLY A 1 274 ? 15.438 -28.269 10.070 1.00 15.11 ? 258 GLY A O 1 ATOM 1903 N N . ALA A 1 275 ? 16.529 -27.281 8.381 1.00 12.58 ? 259 ALA A N 1 ATOM 1904 C CA . ALA A 1 275 ? 17.710 -28.115 8.540 1.00 15.23 ? 259 ALA A CA 1 ATOM 1905 C C . ALA A 1 275 ? 18.399 -27.810 9.870 1.00 12.32 ? 259 ALA A C 1 ATOM 1906 O O . ALA A 1 275 ? 18.928 -28.704 10.508 1.00 11.15 ? 259 ALA A O 1 ATOM 1907 C CB . ALA A 1 275 ? 18.674 -27.914 7.379 1.00 12.53 ? 259 ALA A CB 1 ATOM 1908 N N . MET A 1 276 ? 18.379 -26.549 10.286 1.00 12.09 ? 260 MET A N 1 ATOM 1909 C CA . MET A 1 276 ? 19.019 -26.155 11.535 1.00 14.96 ? 260 MET A CA 1 ATOM 1910 C C . MET A 1 276 ? 18.247 -26.662 12.745 1.00 14.40 ? 260 MET A C 1 ATOM 1911 O O . MET A 1 276 ? 18.845 -27.138 13.698 1.00 12.07 ? 260 MET A O 1 ATOM 1912 C CB . MET A 1 276 ? 19.163 -24.644 11.616 1.00 16.31 ? 260 MET A CB 1 ATOM 1913 C CG . MET A 1 276 ? 20.365 -24.085 10.871 1.00 16.18 ? 260 MET A CG 1 ATOM 1914 S SD . MET A 1 276 ? 21.968 -24.554 11.566 1.00 21.26 ? 260 MET A SD 1 ATOM 1915 C CE . MET A 1 276 ? 21.554 -24.833 13.268 1.00 9.34 ? 260 MET A CE 1 ATOM 1916 N N . HIS A 1 277 ? 16.920 -26.552 12.693 1.00 16.52 ? 261 HIS A N 1 ATOM 1917 C CA . HIS A 1 277 ? 16.042 -27.085 13.728 1.00 15.70 ? 261 HIS A CA 1 ATOM 1918 C C . HIS A 1 277 ? 16.291 -28.580 13.954 1.00 13.58 ? 261 HIS A C 1 ATOM 1919 O O . HIS A 1 277 ? 16.342 -29.035 15.093 1.00 15.17 ? 261 HIS A O 1 ATOM 1920 C CB . HIS A 1 277 ? 14.570 -26.831 13.350 1.00 16.86 ? 261 HIS A CB 1 ATOM 1921 C CG . HIS A 1 277 ? 14.063 -25.459 13.729 1.00 24.97 ? 261 HIS A CG 1 ATOM 1922 N ND1 . HIS A 1 277 ? 14.667 -24.646 14.662 1.00 30.09 ? 261 HIS A ND1 1 ATOM 1923 C CD2 . HIS A 1 277 ? 12.971 -24.774 13.294 1.00 27.98 ? 261 HIS A CD2 1 ATOM 1924 C CE1 . HIS A 1 277 ? 13.990 -23.532 14.789 1.00 23.45 ? 261 HIS A CE1 1 ATOM 1925 N NE2 . HIS A 1 277 ? 12.952 -23.568 13.975 1.00 27.20 ? 261 HIS A NE2 1 ATOM 1926 N N . THR A 1 278 ? 16.473 -29.341 12.880 1.00 12.96 ? 262 THR A N 1 ATOM 1927 C CA . THR A 1 278 ? 16.685 -30.779 13.007 1.00 12.61 ? 262 THR A CA 1 ATOM 1928 C C . THR A 1 278 ? 18.061 -31.099 13.577 1.00 13.09 ? 262 THR A C 1 ATOM 1929 O O . THR A 1 278 ? 18.201 -31.973 14.419 1.00 18.01 ? 262 THR A O 1 ATOM 1930 C CB . THR A 1 278 ? 16.522 -31.475 11.670 1.00 13.84 ? 262 THR A CB 1 ATOM 1931 O OG1 . THR A 1 278 ? 15.201 -31.252 11.168 1.00 12.87 ? 262 THR A OG1 1 ATOM 1932 C CG2 . THR A 1 278 ? 16.741 -32.943 11.837 1.00 19.84 ? 262 THR A CG2 1 ATOM 1933 N N . ALA A 1 279 ? 19.072 -30.375 13.129 1.00 13.11 ? 263 ALA A N 1 ATOM 1934 C CA . ALA A 1 279 ? 20.437 -30.573 13.616 1.00 14.29 ? 263 ALA A CA 1 ATOM 1935 C C . ALA A 1 279 ? 20.569 -30.178 15.065 1.00 12.16 ? 263 ALA A C 1 ATOM 1936 O O . ALA A 1 279 ? 21.412 -30.707 15.777 1.00 14.42 ? 263 ALA A O 1 ATOM 1937 C CB . ALA A 1 279 ? 21.407 -29.784 12.796 1.00 9.97 ? 263 ALA A CB 1 ATOM 1938 N N . LEU A 1 280 ? 19.742 -29.241 15.498 1.00 13.10 ? 264 LEU A N 1 ATOM 1939 C CA . LEU A 1 280 ? 19.753 -28.818 16.889 1.00 12.72 ? 264 LEU A CA 1 ATOM 1940 C C . LEU A 1 280 ? 18.982 -29.791 17.759 1.00 14.02 ? 264 LEU A C 1 ATOM 1941 O O . LEU A 1 280 ? 18.856 -29.574 18.959 1.00 15.35 ? 264 LEU A O 1 ATOM 1942 C CB . LEU A 1 280 ? 19.162 -27.416 17.036 1.00 11.94 ? 264 LEU A CB 1 ATOM 1943 C CG . LEU A 1 280 ? 20.032 -26.234 16.607 1.00 9.86 ? 264 LEU A CG 1 ATOM 1944 C CD1 . LEU A 1 280 ? 19.177 -25.030 16.330 1.00 10.27 ? 264 LEU A CD1 1 ATOM 1945 C CD2 . LEU A 1 280 ? 21.018 -25.907 17.674 1.00 8.93 ? 264 LEU A CD2 1 ATOM 1946 N N . THR A 1 281 ? 18.467 -30.869 17.174 1.00 17.25 ? 265 THR A N 1 ATOM 1947 C CA . THR A 1 281 ? 17.668 -31.800 17.950 1.00 18.12 ? 265 THR A CA 1 ATOM 1948 C C . THR A 1 281 ? 18.518 -32.329 19.082 1.00 14.93 ? 265 THR A C 1 ATOM 1949 O O . THR A 1 281 ? 19.626 -32.791 18.858 1.00 18.05 ? 265 THR A O 1 ATOM 1950 C CB . THR A 1 281 ? 17.141 -32.949 17.084 1.00 19.30 ? 265 THR A CB 1 ATOM 1951 O OG1 . THR A 1 281 ? 16.149 -32.428 16.202 1.00 19.20 ? 265 THR A OG1 1 ATOM 1952 C CG2 . THR A 1 281 ? 16.490 -34.038 17.940 1.00 24.39 ? 265 THR A CG2 1 ATOM 1953 N N . GLY A 1 282 ? 18.007 -32.222 20.304 1.00 18.73 ? 266 GLY A N 1 ATOM 1954 C CA . GLY A 1 282 ? 18.718 -32.685 21.482 1.00 20.47 ? 266 GLY A CA 1 ATOM 1955 C C . GLY A 1 282 ? 19.485 -31.611 22.241 1.00 19.23 ? 266 GLY A C 1 ATOM 1956 O O . GLY A 1 282 ? 19.704 -31.758 23.439 1.00 21.25 ? 266 GLY A O 1 ATOM 1957 N N . ALA A 1 283 ? 19.908 -30.551 21.551 1.00 19.11 ? 267 ALA A N 1 ATOM 1958 C CA . ALA A 1 283 ? 20.575 -29.418 22.199 1.00 14.12 ? 267 ALA A CA 1 ATOM 1959 C C . ALA A 1 283 ? 19.627 -28.751 23.180 1.00 14.43 ? 267 ALA A C 1 ATOM 1960 O O . ALA A 1 283 ? 18.443 -28.623 22.908 1.00 18.64 ? 267 ALA A O 1 ATOM 1961 C CB . ALA A 1 283 ? 21.046 -28.412 21.164 1.00 11.84 ? 267 ALA A CB 1 ATOM 1962 N N . THR A 1 284 ? 20.149 -28.324 24.323 1.00 13.22 ? 268 THR A N 1 ATOM 1963 C CA . THR A 1 284 ? 19.334 -27.680 25.333 1.00 11.32 ? 268 THR A CA 1 ATOM 1964 C C . THR A 1 284 ? 18.804 -26.354 24.846 1.00 13.59 ? 268 THR A C 1 ATOM 1965 O O . THR A 1 284 ? 19.574 -25.483 24.493 1.00 15.63 ? 268 THR A O 1 ATOM 1966 C CB . THR A 1 284 ? 20.131 -27.412 26.592 1.00 12.69 ? 268 THR A CB 1 ATOM 1967 O OG1 . THR A 1 284 ? 20.432 -28.651 27.227 1.00 16.86 ? 268 THR A OG1 1 ATOM 1968 C CG2 . THR A 1 284 ? 19.336 -26.567 27.544 1.00 15.26 ? 268 THR A CG2 1 ATOM 1969 N N . GLU A 1 285 ? 17.482 -26.207 24.852 1.00 13.70 ? 269 GLU A N 1 ATOM 1970 C CA . GLU A 1 285 ? 16.820 -24.941 24.560 1.00 15.42 ? 269 GLU A CA 1 ATOM 1971 C C . GLU A 1 285 ? 16.836 -24.079 25.810 1.00 14.05 ? 269 GLU A C 1 ATOM 1972 O O . GLU A 1 285 ? 16.780 -24.593 26.920 1.00 14.36 ? 269 GLU A O 1 ATOM 1973 C CB . GLU A 1 285 ? 15.372 -25.184 24.128 1.00 14.87 ? 269 GLU A CB 1 ATOM 1974 C CG . GLU A 1 285 ? 14.780 -24.111 23.196 1.00 23.59 ? 269 GLU A CG 1 ATOM 1975 C CD . GLU A 1 285 ? 13.308 -24.392 22.827 1.00 34.81 ? 269 GLU A CD 1 ATOM 1976 O OE1 . GLU A 1 285 ? 12.996 -25.534 22.394 1.00 40.49 ? 269 GLU A OE1 1 ATOM 1977 O OE2 . GLU A 1 285 ? 12.467 -23.471 22.975 1.00 35.75 ? 269 GLU A OE2 1 ATOM 1978 N N . ILE A 1 286 ? 16.891 -22.766 25.642 1.00 14.47 ? 270 ILE A N 1 ATOM 1979 C CA . ILE A 1 286 ? 17.010 -21.878 26.787 1.00 16.77 ? 270 ILE A CA 1 ATOM 1980 C C . ILE A 1 286 ? 16.139 -20.645 26.586 1.00 16.40 ? 270 ILE A C 1 ATOM 1981 O O . ILE A 1 286 ? 15.815 -20.314 25.468 1.00 18.88 ? 270 ILE A O 1 ATOM 1982 C CB . ILE A 1 286 ? 18.491 -21.510 27.030 1.00 15.84 ? 270 ILE A CB 1 ATOM 1983 C CG1 . ILE A 1 286 ? 18.635 -20.721 28.322 1.00 22.28 ? 270 ILE A CG1 1 ATOM 1984 C CG2 . ILE A 1 286 ? 19.052 -20.734 25.855 1.00 14.87 ? 270 ILE A CG2 1 ATOM 1985 C CD1 . ILE A 1 286 ? 19.855 -21.093 29.120 1.00 26.55 ? 270 ILE A CD1 1 ATOM 1986 N N . GLN A 1 287 ? 15.741 -19.988 27.669 1.00 19.61 ? 271 GLN A N 1 ATOM 1987 C CA . GLN A 1 287 ? 14.813 -18.856 27.588 1.00 28.40 ? 271 GLN A CA 1 ATOM 1988 C C . GLN A 1 287 ? 15.523 -17.491 27.640 1.00 26.74 ? 271 GLN A C 1 ATOM 1989 O O . GLN A 1 287 ? 16.171 -17.163 28.631 1.00 23.52 ? 271 GLN A O 1 ATOM 1990 C CB . GLN A 1 287 ? 13.758 -18.960 28.710 1.00 30.03 ? 271 GLN A CB 1 ATOM 1991 C CG . GLN A 1 287 ? 14.323 -18.748 30.121 1.00 32.17 ? 271 GLN A CG 1 ATOM 1992 C CD . GLN A 1 287 ? 13.351 -19.120 31.240 1.00 42.03 ? 271 GLN A CD 1 ATOM 1993 O OE1 . GLN A 1 287 ? 13.643 -19.991 32.073 1.00 38.12 ? 271 GLN A OE1 1 ATOM 1994 N NE2 . GLN A 1 287 ? 12.206 -18.440 31.282 1.00 45.37 ? 271 GLN A NE2 1 ATOM 1995 N N . THR A 1 288 ? 15.395 -16.695 26.577 1.00 27.81 ? 272 THR A N 1 ATOM 1996 C CA . THR A 1 288 ? 16.031 -15.377 26.542 1.00 28.96 ? 272 THR A CA 1 ATOM 1997 C C . THR A 1 288 ? 15.108 -14.248 26.077 1.00 31.58 ? 272 THR A C 1 ATOM 1998 O O . THR A 1 288 ? 14.639 -14.247 24.952 1.00 38.93 ? 272 THR A O 1 ATOM 1999 C CB . THR A 1 288 ? 17.334 -15.375 25.680 1.00 29.51 ? 272 THR A CB 1 ATOM 2000 O OG1 . THR A 1 288 ? 17.298 -14.315 24.718 1.00 30.10 ? 272 THR A OG1 1 ATOM 2001 C CG2 . THR A 1 288 ? 17.530 -16.690 24.979 1.00 27.70 ? 272 THR A CG2 1 ATOM 2002 N N . SER A 1 289 ? 14.851 -13.290 26.967 1.00 35.73 ? 273 SER A N 1 ATOM 2003 C CA . SER A 1 289 ? 14.116 -12.083 26.620 1.00 26.97 ? 273 SER A CA 1 ATOM 2004 C C . SER A 1 289 ? 15.111 -10.960 26.396 1.00 25.65 ? 273 SER A C 1 ATOM 2005 O O . SER A 1 289 ? 15.828 -10.559 27.305 1.00 26.90 ? 273 SER A O 1 ATOM 2006 C CB . SER A 1 289 ? 13.138 -11.705 27.732 1.00 29.41 ? 273 SER A CB 1 ATOM 2007 O OG . SER A 1 289 ? 12.375 -10.569 27.366 1.00 42.56 ? 273 SER A OG 1 ATOM 2008 N N . GLY A 1 290 ? 15.150 -10.458 25.173 1.00 30.68 ? 274 GLY A N 1 ATOM 2009 C CA . GLY A 1 290 ? 16.095 -9.426 24.807 1.00 28.98 ? 274 GLY A CA 1 ATOM 2010 C C . GLY A 1 290 ? 17.522 -9.926 24.851 1.00 24.49 ? 274 GLY A C 1 ATOM 2011 O O . GLY A 1 290 ? 17.923 -10.840 24.140 1.00 28.56 ? 274 GLY A O 1 ATOM 2012 N N . THR A 1 291 ? 18.302 -9.317 25.714 1.00 25.10 ? 275 THR A N 1 ATOM 2013 C CA . THR A 1 291 ? 19.701 -9.642 25.804 1.00 23.17 ? 275 THR A CA 1 ATOM 2014 C C . THR A 1 291 ? 19.969 -10.427 27.044 1.00 17.66 ? 275 THR A C 1 ATOM 2015 O O . THR A 1 291 ? 21.112 -10.595 27.418 1.00 16.02 ? 275 THR A O 1 ATOM 2016 C CB . THR A 1 291 ? 20.498 -8.391 25.973 1.00 22.45 ? 275 THR A CB 1 ATOM 2017 O OG1 . THR A 1 291 ? 20.111 -7.789 27.214 1.00 30.97 ? 275 THR A OG1 1 ATOM 2018 C CG2 . THR A 1 291 ? 20.243 -7.449 24.814 1.00 27.71 ? 275 THR A CG2 1 ATOM 2019 N N . THR A 1 292 ? 18.910 -10.877 27.698 1.00 20.12 ? 276 THR A N 1 ATOM 2020 C CA . THR A 1 292 ? 19.036 -11.565 28.964 1.00 19.11 ? 276 THR A CA 1 ATOM 2021 C C . THR A 1 292 ? 18.654 -13.026 28.813 1.00 15.75 ? 276 THR A C 1 ATOM 2022 O O . THR A 1 292 ? 17.641 -13.356 28.229 1.00 19.14 ? 276 THR A O 1 ATOM 2023 C CB . THR A 1 292 ? 18.145 -10.921 30.021 1.00 20.59 ? 276 THR A CB 1 ATOM 2024 O OG1 . THR A 1 292 ? 18.288 -9.501 29.949 1.00 24.47 ? 276 THR A OG1 1 ATOM 2025 C CG2 . THR A 1 292 ? 18.531 -11.403 31.421 1.00 21.60 ? 276 THR A CG2 1 ATOM 2026 N N . THR A 1 293 ? 19.466 -13.906 29.357 1.00 12.55 ? 277 THR A N 1 ATOM 2027 C CA . THR A 1 293 ? 19.133 -15.305 29.352 1.00 12.46 ? 277 THR A CA 1 ATOM 2028 C C . THR A 1 293 ? 19.143 -15.833 30.781 1.00 11.37 ? 277 THR A C 1 ATOM 2029 O O . THR A 1 293 ? 20.066 -15.586 31.517 1.00 12.00 ? 277 THR A O 1 ATOM 2030 C CB . THR A 1 293 ? 20.120 -16.069 28.506 1.00 13.34 ? 277 THR A CB 1 ATOM 2031 O OG1 . THR A 1 293 ? 20.154 -15.502 27.197 1.00 17.57 ? 277 THR A OG1 1 ATOM 2032 C CG2 . THR A 1 293 ? 19.704 -17.495 28.400 1.00 16.97 ? 277 THR A CG2 1 ATOM 2033 N N . ILE A 1 294 ? 18.091 -16.545 31.171 1.00 14.56 ? 278 ILE A N 1 ATOM 2034 C CA . ILE A 1 294 ? 17.937 -17.002 32.553 1.00 17.10 ? 278 ILE A CA 1 ATOM 2035 C C . ILE A 1 294 ? 18.349 -18.446 32.680 1.00 15.80 ? 278 ILE A C 1 ATOM 2036 O O . ILE A 1 294 ? 17.929 -19.278 31.883 1.00 17.67 ? 278 ILE A O 1 ATOM 2037 C CB . ILE A 1 294 ? 16.484 -16.879 33.031 1.00 20.45 ? 278 ILE A CB 1 ATOM 2038 C CG1 . ILE A 1 294 ? 16.057 -15.411 33.049 1.00 19.22 ? 278 ILE A CG1 1 ATOM 2039 C CG2 . ILE A 1 294 ? 16.323 -17.508 34.391 1.00 18.46 ? 278 ILE A CG2 1 ATOM 2040 C CD1 . ILE A 1 294 ? 16.230 -14.754 34.368 1.00 24.99 ? 278 ILE A CD1 1 ATOM 2041 N N . PHE A 1 295 ? 19.171 -18.736 33.686 1.00 13.35 ? 279 PHE A N 1 ATOM 2042 C CA . PHE A 1 295 ? 19.680 -20.076 33.910 1.00 14.67 ? 279 PHE A CA 1 ATOM 2043 C C . PHE A 1 295 ? 19.185 -20.606 35.241 1.00 13.63 ? 279 PHE A C 1 ATOM 2044 O O . PHE A 1 295 ? 18.593 -19.877 36.032 1.00 15.84 ? 279 PHE A O 1 ATOM 2045 C CB . PHE A 1 295 ? 21.208 -20.076 33.899 1.00 15.03 ? 279 PHE A CB 1 ATOM 2046 C CG . PHE A 1 295 ? 21.802 -19.927 32.538 1.00 13.41 ? 279 PHE A CG 1 ATOM 2047 C CD1 . PHE A 1 295 ? 21.889 -18.688 31.942 1.00 12.84 ? 279 PHE A CD1 1 ATOM 2048 C CD2 . PHE A 1 295 ? 22.268 -21.030 31.851 1.00 18.27 ? 279 PHE A CD2 1 ATOM 2049 C CE1 . PHE A 1 295 ? 22.424 -18.550 30.693 1.00 16.78 ? 279 PHE A CE1 1 ATOM 2050 C CE2 . PHE A 1 295 ? 22.808 -20.901 30.589 1.00 19.22 ? 279 PHE A CE2 1 ATOM 2051 C CZ . PHE A 1 295 ? 22.886 -19.662 30.009 1.00 20.51 ? 279 PHE A CZ 1 ATOM 2052 N N . ALA A 1 296 ? 19.417 -21.890 35.475 1.00 16.29 ? 280 ALA A N 1 ATOM 2053 C CA . ALA A 1 296 ? 19.164 -22.497 36.772 1.00 14.89 ? 280 ALA A CA 1 ATOM 2054 C C . ALA A 1 296 ? 20.477 -22.644 37.493 1.00 12.25 ? 280 ALA A C 1 ATOM 2055 O O . ALA A 1 296 ? 21.066 -23.710 37.483 1.00 20.43 ? 280 ALA A O 1 ATOM 2056 C CB . ALA A 1 296 ? 18.525 -23.852 36.602 1.00 17.35 ? 280 ALA A CB 1 ATOM 2057 N N . GLY A 1 297 ? 20.921 -21.578 38.137 1.00 11.91 ? 281 GLY A N 1 ATOM 2058 C CA . GLY A 1 297 ? 22.269 -21.502 38.663 1.00 12.34 ? 281 GLY A CA 1 ATOM 2059 C C . GLY A 1 297 ? 22.596 -22.312 39.903 1.00 9.94 ? 281 GLY A C 1 ATOM 2060 O O . GLY A 1 297 ? 21.744 -22.779 40.644 1.00 13.70 ? 281 GLY A O 1 ATOM 2061 N N . HIS A 1 298 ? 23.884 -22.442 40.144 1.00 12.71 ? 282 HIS A N 1 ATOM 2062 C CA . HIS A 1 298 ? 24.371 -23.124 41.323 1.00 13.57 ? 282 HIS A CA 1 ATOM 2063 C C . HIS A 1 298 ? 25.588 -22.399 41.869 1.00 10.28 ? 282 HIS A C 1 ATOM 2064 O O . HIS A 1 298 ? 26.528 -22.124 41.145 1.00 8.12 ? 282 HIS A O 1 ATOM 2065 C CB . HIS A 1 298 ? 24.744 -24.547 40.971 1.00 17.23 ? 282 HIS A CB 1 ATOM 2066 C CG . HIS A 1 298 ? 23.614 -25.352 40.419 1.00 19.26 ? 282 HIS A CG 1 ATOM 2067 N ND1 . HIS A 1 298 ? 22.445 -25.588 41.118 1.00 21.26 ? 282 HIS A ND1 1 ATOM 2068 C CD2 . HIS A 1 298 ? 23.472 -26.003 39.240 1.00 21.73 ? 282 HIS A CD2 1 ATOM 2069 C CE1 . HIS A 1 298 ? 21.641 -26.326 40.397 1.00 22.62 ? 282 HIS A CE1 1 ATOM 2070 N NE2 . HIS A 1 298 ? 22.234 -26.598 39.244 1.00 25.33 ? 282 HIS A NE2 1 ATOM 2071 N N . LEU A 1 299 ? 25.561 -22.095 43.155 1.00 10.00 ? 283 LEU A N 1 ATOM 2072 C CA . LEU A 1 299 ? 26.639 -21.353 43.790 1.00 10.62 ? 283 LEU A CA 1 ATOM 2073 C C . LEU A 1 299 ? 27.200 -22.092 44.993 1.00 9.14 ? 283 LEU A C 1 ATOM 2074 O O . LEU A 1 299 ? 26.448 -22.629 45.784 1.00 9.82 ? 283 LEU A O 1 ATOM 2075 C CB . LEU A 1 299 ? 26.121 -19.995 44.274 1.00 10.16 ? 283 LEU A CB 1 ATOM 2076 C CG . LEU A 1 299 ? 25.985 -18.819 43.318 1.00 9.95 ? 283 LEU A CG 1 ATOM 2077 C CD1 . LEU A 1 299 ? 25.496 -17.649 44.117 1.00 12.51 ? 283 LEU A CD1 1 ATOM 2078 C CD2 . LEU A 1 299 ? 27.302 -18.466 42.626 1.00 9.12 ? 283 LEU A CD2 1 ATOM 2079 N N . LYS A 1 300 ? 28.518 -22.093 45.135 1.00 8.76 ? 284 LYS A N 1 ATOM 2080 C CA . LYS A 1 300 ? 29.152 -22.470 46.395 1.00 10.50 ? 284 LYS A CA 1 ATOM 2081 C C . LYS A 1 300 ? 29.614 -21.192 47.089 1.00 10.18 ? 284 LYS A C 1 ATOM 2082 O O . LYS A 1 300 ? 30.337 -20.393 46.498 1.00 11.78 ? 284 LYS A O 1 ATOM 2083 C CB . LYS A 1 300 ? 30.337 -23.419 46.181 1.00 9.54 ? 284 LYS A CB 1 ATOM 2084 C CG . LYS A 1 300 ? 30.965 -23.884 47.485 1.00 14.50 ? 284 LYS A CG 1 ATOM 2085 C CD . LYS A 1 300 ? 32.275 -24.625 47.263 1.00 30.68 ? 284 LYS A CD 1 ATOM 2086 C CE . LYS A 1 300 ? 32.620 -25.554 48.450 1.00 45.13 ? 284 LYS A CE 1 ATOM 2087 N NZ . LYS A 1 300 ? 31.639 -26.678 48.676 1.00 34.85 ? 284 LYS A NZ 1 ATOM 2088 N N . CYS A 1 301 ? 29.215 -21.005 48.347 1.00 11.18 ? 285 CYS A N 1 ATOM 2089 C CA . CYS A 1 301 ? 29.539 -19.793 49.094 1.00 10.67 ? 285 CYS A CA 1 ATOM 2090 C C . CYS A 1 301 ? 30.316 -20.030 50.398 1.00 11.02 ? 285 CYS A C 1 ATOM 2091 O O . CYS A 1 301 ? 30.138 -21.058 51.070 1.00 10.11 ? 285 CYS A O 1 ATOM 2092 C CB . CYS A 1 301 ? 28.251 -19.029 49.418 1.00 9.62 ? 285 CYS A CB 1 ATOM 2093 S SG . CYS A 1 301 ? 27.304 -18.507 47.975 1.00 18.11 ? 285 CYS A SG 1 ATOM 2094 N N . ARG A 1 302 ? 31.187 -19.069 50.716 1.00 9.12 ? 286 ARG A N 1 ATOM 2095 C CA . ARG A 1 302 ? 31.742 -18.906 52.055 1.00 8.89 ? 286 ARG A CA 1 ATOM 2096 C C . ARG A 1 302 ? 31.097 -17.685 52.719 1.00 9.38 ? 286 ARG A C 1 ATOM 2097 O O . ARG A 1 302 ? 31.048 -16.603 52.140 1.00 10.07 ? 286 ARG A O 1 ATOM 2098 C CB . ARG A 1 302 ? 33.267 -18.761 51.995 1.00 7.81 ? 286 ARG A CB 1 ATOM 2099 C CG . ARG A 1 302 ? 33.964 -18.356 53.310 1.00 6.56 ? 286 ARG A CG 1 ATOM 2100 C CD . ARG A 1 302 ? 33.788 -19.354 54.492 1.00 7.12 ? 286 ARG A CD 1 ATOM 2101 N NE . ARG A 1 302 ? 34.137 -20.742 54.169 1.00 8.71 ? 286 ARG A NE 1 ATOM 2102 C CZ . ARG A 1 302 ? 35.368 -21.236 54.140 1.00 7.79 ? 286 ARG A CZ 1 ATOM 2103 N NH1 . ARG A 1 302 ? 36.423 -20.479 54.403 1.00 7.87 ? 286 ARG A NH1 1 ATOM 2104 N NH2 . ARG A 1 302 ? 35.548 -22.504 53.816 1.00 9.37 ? 286 ARG A NH2 1 ATOM 2105 N N . LEU A 1 303 ? 30.553 -17.882 53.910 1.00 8.11 ? 287 LEU A N 1 ATOM 2106 C CA . LEU A 1 303 ? 30.039 -16.790 54.723 1.00 8.35 ? 287 LEU A CA 1 ATOM 2107 C C . LEU A 1 303 ? 31.062 -16.481 55.809 1.00 7.44 ? 287 LEU A C 1 ATOM 2108 O O . LEU A 1 303 ? 31.540 -17.382 56.488 1.00 8.15 ? 287 LEU A O 1 ATOM 2109 C CB . LEU A 1 303 ? 28.722 -17.204 55.385 1.00 8.55 ? 287 LEU A CB 1 ATOM 2110 C CG . LEU A 1 303 ? 27.382 -17.139 54.644 1.00 11.64 ? 287 LEU A CG 1 ATOM 2111 C CD1 . LEU A 1 303 ? 27.484 -17.390 53.169 1.00 15.11 ? 287 LEU A CD1 1 ATOM 2112 C CD2 . LEU A 1 303 ? 26.418 -18.119 55.266 1.00 13.21 ? 287 LEU A CD2 1 ATOM 2113 N N . LYS A 1 304 ? 31.429 -15.217 55.955 1.00 7.41 ? 288 LYS A N 1 ATOM 2114 C CA . LYS A 1 304 ? 32.353 -14.809 56.998 1.00 6.77 ? 288 LYS A CA 1 ATOM 2115 C C . LYS A 1 304 ? 31.636 -13.826 57.855 1.00 9.70 ? 288 LYS A C 1 ATOM 2116 O O . LYS A 1 304 ? 31.157 -12.827 57.369 1.00 11.06 ? 288 LYS A O 1 ATOM 2117 C CB . LYS A 1 304 ? 33.588 -14.104 56.449 1.00 6.87 ? 288 LYS A CB 1 ATOM 2118 C CG . LYS A 1 304 ? 34.273 -14.816 55.336 1.00 7.03 ? 288 LYS A CG 1 ATOM 2119 C CD . LYS A 1 304 ? 35.517 -14.117 54.971 1.00 6.69 ? 288 LYS A CD 1 ATOM 2120 C CE . LYS A 1 304 ? 36.239 -14.903 53.961 1.00 12.51 ? 288 LYS A CE 1 ATOM 2121 N NZ . LYS A 1 304 ? 37.413 -14.144 53.500 1.00 17.98 ? 288 LYS A NZ 1 ATOM 2122 N N . MET A 1 305 ? 31.585 -14.105 59.139 1.00 9.13 ? 289 MET A N 1 ATOM 2123 C CA . MET A 1 305 ? 31.001 -13.178 60.076 1.00 12.31 ? 289 MET A CA 1 ATOM 2124 C C . MET A 1 305 ? 31.864 -13.131 61.316 1.00 11.67 ? 289 MET A C 1 ATOM 2125 O O . MET A 1 305 ? 32.878 -13.812 61.413 1.00 13.02 ? 289 MET A O 1 ATOM 2126 C CB . MET A 1 305 ? 29.584 -13.608 60.400 1.00 12.03 ? 289 MET A CB 1 ATOM 2127 C CG . MET A 1 305 ? 29.449 -15.064 60.674 1.00 11.96 ? 289 MET A CG 1 ATOM 2128 S SD . MET A 1 305 ? 27.725 -15.507 60.904 1.00 30.35 ? 289 MET A SD 1 ATOM 2129 C CE . MET A 1 305 ? 27.435 -16.642 59.559 1.00 12.86 ? 289 MET A CE 1 ATOM 2130 N N . ASP A 1 306 ? 31.491 -12.308 62.272 1.00 13.84 ? 290 ASP A N 1 ATOM 2131 C CA . ASP A 1 306 ? 32.299 -12.220 63.454 1.00 17.00 ? 290 ASP A CA 1 ATOM 2132 C C . ASP A 1 306 ? 32.124 -13.471 64.295 1.00 10.78 ? 290 ASP A C 1 ATOM 2133 O O . ASP A 1 306 ? 31.131 -14.166 64.198 1.00 11.99 ? 290 ASP A O 1 ATOM 2134 C CB . ASP A 1 306 ? 32.007 -10.932 64.208 1.00 20.87 ? 290 ASP A CB 1 ATOM 2135 C CG . ASP A 1 306 ? 32.575 -9.709 63.495 1.00 23.07 ? 290 ASP A CG 1 ATOM 2136 O OD1 . ASP A 1 306 ? 33.779 -9.420 63.657 1.00 25.92 ? 290 ASP A OD1 1 ATOM 2137 O OD2 . ASP A 1 306 ? 31.829 -9.049 62.742 1.00 33.07 ? 290 ASP A OD2 1 ATOM 2138 N N . LYS A 1 307 ? 33.149 -13.757 65.080 1.00 15.00 ? 291 LYS A N 1 ATOM 2139 C CA . LYS A 1 307 ? 33.214 -14.938 65.920 1.00 12.50 ? 291 LYS A CA 1 ATOM 2140 C C . LYS A 1 307 ? 31.876 -15.158 66.599 1.00 13.15 ? 291 LYS A C 1 ATOM 2141 O O . LYS A 1 307 ? 31.382 -14.302 67.312 1.00 15.36 ? 291 LYS A O 1 ATOM 2142 C CB . LYS A 1 307 ? 34.331 -14.744 66.938 1.00 13.00 ? 291 LYS A CB 1 ATOM 2143 C CG . LYS A 1 307 ? 34.885 -15.991 67.508 1.00 11.78 ? 291 LYS A CG 1 ATOM 2144 C CD . LYS A 1 307 ? 35.912 -15.666 68.551 1.00 12.50 ? 291 LYS A CD 1 ATOM 2145 C CE . LYS A 1 307 ? 35.528 -16.241 69.888 1.00 15.08 ? 291 LYS A CE 1 ATOM 2146 N NZ . LYS A 1 307 ? 35.509 -17.728 69.913 1.00 13.87 ? 291 LYS A NZ 1 ATOM 2147 N N . LEU A 1 308 ? 31.287 -16.320 66.378 1.00 14.48 ? 292 LEU A N 1 ATOM 2148 C CA . LEU A 1 308 ? 29.937 -16.568 66.837 1.00 11.58 ? 292 LEU A CA 1 ATOM 2149 C C . LEU A 1 308 ? 29.634 -18.046 66.864 1.00 12.07 ? 292 LEU A C 1 ATOM 2150 O O . LEU A 1 308 ? 30.048 -18.784 65.976 1.00 14.55 ? 292 LEU A O 1 ATOM 2151 C CB . LEU A 1 308 ? 29.006 -15.879 65.871 1.00 17.74 ? 292 LEU A CB 1 ATOM 2152 C CG . LEU A 1 308 ? 27.538 -16.050 66.092 1.00 17.95 ? 292 LEU A CG 1 ATOM 2153 C CD1 . LEU A 1 308 ? 27.202 -15.531 67.469 1.00 29.28 ? 292 LEU A CD1 1 ATOM 2154 C CD2 . LEU A 1 308 ? 26.833 -15.275 65.004 1.00 23.99 ? 292 LEU A CD2 1 ATOM 2155 N N . THR A 1 309 ? 28.921 -18.491 67.881 1.00 13.13 ? 293 THR A N 1 ATOM 2156 C CA . THR A 1 309 ? 28.622 -19.904 68.014 1.00 13.96 ? 293 THR A CA 1 ATOM 2157 C C . THR A 1 309 ? 27.297 -20.221 67.322 1.00 16.18 ? 293 THR A C 1 ATOM 2158 O O . THR A 1 309 ? 26.236 -19.826 67.780 1.00 15.50 ? 293 THR A O 1 ATOM 2159 C CB . THR A 1 309 ? 28.600 -20.331 69.493 1.00 17.84 ? 293 THR A CB 1 ATOM 2160 O OG1 . THR A 1 309 ? 29.646 -19.648 70.195 1.00 24.29 ? 293 THR A OG1 1 ATOM 2161 C CG2 . THR A 1 309 ? 28.790 -21.842 69.657 1.00 14.29 ? 293 THR A CG2 1 ATOM 2162 N N . LEU A 1 310 ? 27.376 -20.909 66.189 1.00 13.08 ? 294 LEU A N 1 ATOM 2163 C CA . LEU A 1 310 ? 26.191 -21.265 65.439 1.00 12.33 ? 294 LEU A CA 1 ATOM 2164 C C . LEU A 1 310 ? 25.603 -22.536 65.994 1.00 16.28 ? 294 LEU A C 1 ATOM 2165 O O . LEU A 1 310 ? 26.305 -23.364 66.574 1.00 14.34 ? 294 LEU A O 1 ATOM 2166 C CB . LEU A 1 310 ? 26.508 -21.475 63.959 1.00 12.88 ? 294 LEU A CB 1 ATOM 2167 C CG . LEU A 1 310 ? 27.033 -20.271 63.186 1.00 10.06 ? 294 LEU A CG 1 ATOM 2168 C CD1 . LEU A 1 310 ? 27.204 -20.590 61.697 1.00 14.21 ? 294 LEU A CD1 1 ATOM 2169 C CD2 . LEU A 1 310 ? 26.117 -19.081 63.395 1.00 13.16 ? 294 LEU A CD2 1 ATOM 2170 N N . LYS A 1 311 ? 24.304 -22.681 65.780 1.00 18.24 ? 295 LYS A N 1 ATOM 2171 C CA . LYS A 1 311 ? 23.590 -23.892 66.110 1.00 20.57 ? 295 LYS A CA 1 ATOM 2172 C C . LYS A 1 311 ? 23.514 -24.803 64.890 1.00 18.74 ? 295 LYS A C 1 ATOM 2173 O O . LYS A 1 311 ? 22.635 -24.652 64.058 1.00 17.03 ? 295 LYS A O 1 ATOM 2174 C CB . LYS A 1 311 ? 22.187 -23.527 66.584 1.00 26.51 ? 295 LYS A CB 1 ATOM 2175 C CG . LYS A 1 311 ? 21.287 -24.710 66.901 1.00 36.80 ? 295 LYS A CG 1 ATOM 2176 C CD . LYS A 1 311 ? 19.812 -24.322 66.776 1.00 47.53 ? 295 LYS A CD 1 ATOM 2177 C CE . LYS A 1 311 ? 19.377 -24.116 65.306 1.00 38.12 ? 295 LYS A CE 1 ATOM 2178 N NZ . LYS A 1 311 ? 17.900 -23.795 65.190 1.00 39.55 ? 295 LYS A NZ 1 ATOM 2179 N N . GLY A 1 312 ? 24.456 -25.741 64.792 1.00 19.03 ? 296 GLY A N 1 ATOM 2180 C CA . GLY A 1 312 ? 24.488 -26.697 63.702 1.00 14.73 ? 296 GLY A CA 1 ATOM 2181 C C . GLY A 1 312 ? 23.304 -27.639 63.741 1.00 19.22 ? 296 GLY A C 1 ATOM 2182 O O . GLY A 1 312 ? 22.874 -28.057 64.816 1.00 23.64 ? 296 GLY A O 1 ATOM 2183 N N . MET A 1 313 ? 22.787 -27.988 62.565 1.00 18.11 ? 297 MET A N 1 ATOM 2184 C CA . MET A 1 313 ? 21.561 -28.773 62.441 1.00 15.73 ? 297 MET A CA 1 ATOM 2185 C C . MET A 1 313 ? 21.896 -30.170 61.964 1.00 17.15 ? 297 MET A C 1 ATOM 2186 O O . MET A 1 313 ? 22.630 -30.335 61.014 1.00 20.91 ? 297 MET A O 1 ATOM 2187 C CB . MET A 1 313 ? 20.607 -28.085 61.465 1.00 17.15 ? 297 MET A CB 1 ATOM 2188 C CG . MET A 1 313 ? 19.357 -28.862 61.144 1.00 18.65 ? 297 MET A CG 1 ATOM 2189 S SD . MET A 1 313 ? 18.243 -28.914 62.551 1.00 31.56 ? 297 MET A SD 1 ATOM 2190 C CE . MET A 1 313 ? 17.056 -30.163 62.037 1.00 27.75 ? 297 MET A CE 1 ATOM 2191 N N . SER A 1 314 ? 21.360 -31.179 62.639 1.00 21.52 ? 298 SER A N 1 ATOM 2192 C CA . SER A 1 314 ? 21.628 -32.564 62.299 1.00 20.79 ? 298 SER A CA 1 ATOM 2193 C C . SER A 1 314 ? 20.402 -33.173 61.672 1.00 21.18 ? 298 SER A C 1 ATOM 2194 O O . SER A 1 314 ? 19.287 -32.811 62.026 1.00 22.52 ? 298 SER A O 1 ATOM 2195 C CB . SER A 1 314 ? 21.986 -33.341 63.555 1.00 25.81 ? 298 SER A CB 1 ATOM 2196 O OG . SER A 1 314 ? 23.355 -33.164 63.858 1.00 38.18 ? 298 SER A OG 1 ATOM 2197 N N . TYR A 1 315 ? 20.594 -34.097 60.743 1.00 19.49 ? 299 TYR A N 1 ATOM 2198 C CA . TYR A 1 315 ? 19.460 -34.831 60.193 1.00 22.12 ? 299 TYR A CA 1 ATOM 2199 C C . TYR A 1 315 ? 19.745 -36.333 60.183 1.00 21.87 ? 299 TYR A C 1 ATOM 2200 O O . TYR A 1 315 ? 20.830 -36.755 59.777 1.00 23.17 ? 299 TYR A O 1 ATOM 2201 C CB . TYR A 1 315 ? 19.130 -34.365 58.767 1.00 19.87 ? 299 TYR A CB 1 ATOM 2202 C CG . TYR A 1 315 ? 18.758 -32.895 58.603 1.00 16.97 ? 299 TYR A CG 1 ATOM 2203 C CD1 . TYR A 1 315 ? 17.455 -32.464 58.769 1.00 15.96 ? 299 TYR A CD1 1 ATOM 2204 C CD2 . TYR A 1 315 ? 19.707 -31.957 58.238 1.00 15.61 ? 299 TYR A CD2 1 ATOM 2205 C CE1 . TYR A 1 315 ? 17.113 -31.149 58.600 1.00 16.47 ? 299 TYR A CE1 1 ATOM 2206 C CE2 . TYR A 1 315 ? 19.372 -30.632 58.071 1.00 16.14 ? 299 TYR A CE2 1 ATOM 2207 C CZ . TYR A 1 315 ? 18.071 -30.233 58.249 1.00 14.55 ? 299 TYR A CZ 1 ATOM 2208 O OH . TYR A 1 315 ? 17.706 -28.916 58.083 1.00 13.05 ? 299 TYR A OH 1 ATOM 2209 N N . VAL A 1 316 ? 18.768 -37.132 60.624 1.00 22.95 ? 300 VAL A N 1 ATOM 2210 C CA . VAL A 1 316 ? 18.872 -38.602 60.566 1.00 21.28 ? 300 VAL A CA 1 ATOM 2211 C C . VAL A 1 316 ? 18.547 -39.058 59.156 1.00 16.18 ? 300 VAL A C 1 ATOM 2212 O O . VAL A 1 316 ? 17.787 -38.405 58.455 1.00 19.03 ? 300 VAL A O 1 ATOM 2213 C CB . VAL A 1 316 ? 17.922 -39.342 61.579 1.00 20.42 ? 300 VAL A CB 1 ATOM 2214 C CG1 . VAL A 1 316 ? 18.421 -39.204 62.985 1.00 24.74 ? 300 VAL A CG1 1 ATOM 2215 C CG2 . VAL A 1 316 ? 16.481 -38.849 61.484 1.00 20.27 ? 300 VAL A CG2 1 ATOM 2216 N N . MET A 1 317 ? 19.128 -40.166 58.726 1.00 20.76 ? 301 MET A N 1 ATOM 2217 C CA . MET A 1 317 ? 18.809 -40.670 57.409 1.00 18.59 ? 301 MET A CA 1 ATOM 2218 C C . MET A 1 317 ? 17.330 -41.001 57.415 1.00 20.99 ? 301 MET A C 1 ATOM 2219 O O . MET A 1 317 ? 16.812 -41.527 58.392 1.00 18.96 ? 301 MET A O 1 ATOM 2220 C CB . MET A 1 317 ? 19.604 -41.920 57.071 1.00 19.45 ? 301 MET A CB 1 ATOM 2221 C CG . MET A 1 317 ? 21.099 -41.757 57.093 1.00 18.91 ? 301 MET A CG 1 ATOM 2222 S SD . MET A 1 317 ? 21.749 -40.559 55.940 1.00 27.61 ? 301 MET A SD 1 ATOM 2223 C CE . MET A 1 317 ? 20.948 -41.000 54.424 1.00 16.29 ? 301 MET A CE 1 ATOM 2224 N N . CYS A 1 318 ? 16.648 -40.678 56.325 1.00 17.71 ? 302 CYS A N 1 ATOM 2225 C CA . CYS A 1 318 ? 15.253 -41.013 56.184 1.00 17.29 ? 302 CYS A CA 1 ATOM 2226 C C . CYS A 1 318 ? 15.144 -42.517 56.398 1.00 18.29 ? 302 CYS A C 1 ATOM 2227 O O . CYS A 1 318 ? 16.136 -43.208 56.265 1.00 20.58 ? 302 CYS A O 1 ATOM 2228 C CB . CYS A 1 318 ? 14.757 -40.589 54.797 1.00 18.03 ? 302 CYS A CB 1 ATOM 2229 S SG . CYS A 1 318 ? 14.563 -38.783 54.574 1.00 19.60 ? 302 CYS A SG 1 ATOM 2230 N N . THR A 1 319 ? 13.968 -43.013 56.785 1.00 22.00 ? 303 THR A N 1 ATOM 2231 C CA . THR A 1 319 ? 13.757 -44.462 56.963 1.00 18.11 ? 303 THR A CA 1 ATOM 2232 C C . THR A 1 319 ? 12.613 -45.026 56.134 1.00 17.09 ? 303 THR A C 1 ATOM 2233 O O . THR A 1 319 ? 12.556 -46.242 55.929 1.00 19.71 ? 303 THR A O 1 ATOM 2234 C CB . THR A 1 319 ? 13.494 -44.861 58.432 1.00 17.10 ? 303 THR A CB 1 ATOM 2235 O OG1 . THR A 1 319 ? 12.198 -44.405 58.838 1.00 21.53 ? 303 THR A OG1 1 ATOM 2236 C CG2 . THR A 1 319 ? 14.557 -44.294 59.345 1.00 19.56 ? 303 THR A CG2 1 ATOM 2237 N N . GLY A 1 320 ? 11.713 -44.158 55.660 1.00 17.01 ? 304 GLY A N 1 ATOM 2238 C CA . GLY A 1 320 ? 10.599 -44.568 54.811 1.00 17.40 ? 304 GLY A CA 1 ATOM 2239 C C . GLY A 1 320 ? 10.885 -44.721 53.307 1.00 21.35 ? 304 GLY A C 1 ATOM 2240 O O . GLY A 1 320 ? 12.029 -44.876 52.869 1.00 18.49 ? 304 GLY A O 1 ATOM 2241 N N . SER A 1 321 ? 9.824 -44.684 52.502 1.00 24.25 ? 305 SER A N 1 ATOM 2242 C CA . SER A 1 321 ? 9.938 -44.899 51.059 1.00 22.93 ? 305 SER A CA 1 ATOM 2243 C C . SER A 1 321 ? 9.781 -43.613 50.249 1.00 19.13 ? 305 SER A C 1 ATOM 2244 O O . SER A 1 321 ? 9.220 -42.629 50.730 1.00 17.29 ? 305 SER A O 1 ATOM 2245 C CB . SER A 1 321 ? 8.917 -45.927 50.558 1.00 23.17 ? 305 SER A CB 1 ATOM 2246 O OG . SER A 1 321 ? 7.708 -45.913 51.291 1.00 35.79 ? 305 SER A OG 1 ATOM 2247 N N . PHE A 1 322 ? 10.278 -43.664 49.010 1.00 21.07 ? 306 PHE A N 1 ATOM 2248 C CA . PHE A 1 322 ? 10.231 -42.560 48.053 1.00 18.57 ? 306 PHE A CA 1 ATOM 2249 C C . PHE A 1 322 ? 9.578 -42.961 46.732 1.00 17.29 ? 306 PHE A C 1 ATOM 2250 O O . PHE A 1 322 ? 9.835 -44.035 46.204 1.00 22.16 ? 306 PHE A O 1 ATOM 2251 C CB . PHE A 1 322 ? 11.649 -42.079 47.730 1.00 15.26 ? 306 PHE A CB 1 ATOM 2252 C CG . PHE A 1 322 ? 12.377 -41.515 48.901 1.00 14.03 ? 306 PHE A CG 1 ATOM 2253 C CD1 . PHE A 1 322 ? 13.084 -42.337 49.757 1.00 14.89 ? 306 PHE A CD1 1 ATOM 2254 C CD2 . PHE A 1 322 ? 12.359 -40.158 49.145 1.00 16.57 ? 306 PHE A CD2 1 ATOM 2255 C CE1 . PHE A 1 322 ? 13.749 -41.822 50.840 1.00 14.73 ? 306 PHE A CE1 1 ATOM 2256 C CE2 . PHE A 1 322 ? 13.022 -39.625 50.231 1.00 13.76 ? 306 PHE A CE2 1 ATOM 2257 C CZ . PHE A 1 322 ? 13.718 -40.458 51.081 1.00 17.94 ? 306 PHE A CZ 1 ATOM 2258 N N . LYS A 1 323 ? 8.750 -42.084 46.189 1.00 18.58 ? 307 LYS A N 1 ATOM 2259 C CA . LYS A 1 323 ? 8.210 -42.286 44.852 1.00 19.98 ? 307 LYS A CA 1 ATOM 2260 C C . LYS A 1 323 ? 8.778 -41.244 43.883 1.00 19.60 ? 307 LYS A C 1 ATOM 2261 O O . LYS A 1 323 ? 9.170 -40.142 44.269 1.00 18.08 ? 307 LYS A O 1 ATOM 2262 C CB . LYS A 1 323 ? 6.680 -42.198 44.870 1.00 24.52 ? 307 LYS A CB 1 ATOM 2263 C CG . LYS A 1 323 ? 5.948 -43.510 45.178 1.00 36.38 ? 307 LYS A CG 1 ATOM 2264 C CD . LYS A 1 323 ? 4.443 -43.406 44.816 1.00 54.74 ? 307 LYS A CD 1 ATOM 2265 C CE . LYS A 1 323 ? 3.756 -44.768 44.588 1.00 48.07 ? 307 LYS A CE 1 ATOM 2266 N NZ . LYS A 1 323 ? 2.455 -44.645 43.831 1.00 46.72 ? 307 LYS A NZ 1 ATOM 2267 N N . LEU A 1 324 ? 8.811 -41.591 42.610 1.00 21.02 ? 308 LEU A N 1 ATOM 2268 C CA . LEU A 1 324 ? 9.250 -40.656 41.595 1.00 19.77 ? 308 LEU A CA 1 ATOM 2269 C C . LEU A 1 324 ? 8.102 -39.762 41.217 1.00 22.57 ? 308 LEU A C 1 ATOM 2270 O O . LEU A 1 324 ? 7.136 -40.251 40.639 1.00 27.08 ? 308 LEU A O 1 ATOM 2271 C CB . LEU A 1 324 ? 9.658 -41.428 40.362 1.00 20.87 ? 308 LEU A CB 1 ATOM 2272 C CG . LEU A 1 324 ? 11.096 -41.224 39.942 1.00 24.62 ? 308 LEU A CG 1 ATOM 2273 C CD1 . LEU A 1 324 ? 12.046 -41.511 41.090 1.00 20.27 ? 308 LEU A CD1 1 ATOM 2274 C CD2 . LEU A 1 324 ? 11.302 -42.148 38.820 1.00 21.30 ? 308 LEU A CD2 1 ATOM 2275 N N . GLU A 1 325 ? 8.186 -38.470 41.537 1.00 24.35 ? 309 GLU A N 1 ATOM 2276 C CA . GLU A 1 325 ? 7.110 -37.544 41.181 1.00 22.75 ? 309 GLU A CA 1 ATOM 2277 C C . GLU A 1 325 ? 7.132 -37.311 39.677 1.00 23.45 ? 309 GLU A C 1 ATOM 2278 O O . GLU A 1 325 ? 6.127 -36.932 39.083 1.00 27.00 ? 309 GLU A O 1 ATOM 2279 C CB . GLU A 1 325 ? 7.194 -36.223 41.963 1.00 23.39 ? 309 GLU A CB 1 ATOM 2280 C CG . GLU A 1 325 ? 5.949 -35.301 41.833 1.00 32.94 ? 309 GLU A CG 1 ATOM 2281 C CD . GLU A 1 325 ? 4.782 -35.684 42.735 1.00 34.38 ? 309 GLU A CD 1 ATOM 2282 O OE1 . GLU A 1 325 ? 4.888 -36.709 43.430 1.00 36.76 ? 309 GLU A OE1 1 ATOM 2283 O OE2 . GLU A 1 325 ? 3.763 -34.949 42.756 1.00 30.61 ? 309 GLU A OE2 1 ATOM 2284 N N . LYS A 1 326 ? 8.271 -37.560 39.046 1.00 21.66 ? 310 LYS A N 1 ATOM 2285 C CA . LYS A 1 326 ? 8.308 -37.469 37.602 1.00 23.51 ? 310 LYS A CA 1 ATOM 2286 C C . LYS A 1 326 ? 9.490 -38.211 36.987 1.00 21.73 ? 310 LYS A C 1 ATOM 2287 O O . LYS A 1 326 ? 10.347 -38.742 37.686 1.00 21.00 ? 310 LYS A O 1 ATOM 2288 C CB . LYS A 1 326 ? 8.247 -36.007 37.141 1.00 26.36 ? 310 LYS A CB 1 ATOM 2289 C CG . LYS A 1 326 ? 9.361 -35.096 37.624 1.00 25.44 ? 310 LYS A CG 1 ATOM 2290 C CD . LYS A 1 326 ? 8.942 -33.640 37.450 1.00 28.97 ? 310 LYS A CD 1 ATOM 2291 C CE . LYS A 1 326 ? 10.136 -32.691 37.311 1.00 39.05 ? 310 LYS A CE 1 ATOM 2292 N NZ . LYS A 1 326 ? 9.738 -31.303 36.899 1.00 43.36 ? 310 LYS A NZ 1 ATOM 2293 N N . GLU A 1 327 ? 9.509 -38.271 35.666 1.00 19.26 ? 311 GLU A N 1 ATOM 2294 C CA . GLU A 1 327 ? 10.503 -39.064 34.974 1.00 21.82 ? 311 GLU A CA 1 ATOM 2295 C C . GLU A 1 327 ? 11.908 -38.465 35.182 1.00 20.55 ? 311 GLU A C 1 ATOM 2296 O O . GLU A 1 327 ? 12.071 -37.256 35.291 1.00 20.54 ? 311 GLU A O 1 ATOM 2297 C CB . GLU A 1 327 ? 10.130 -39.153 33.492 1.00 21.86 ? 311 GLU A CB 1 ATOM 2298 C CG . GLU A 1 327 ? 10.838 -40.229 32.710 1.00 18.81 ? 311 GLU A CG 1 ATOM 2299 C CD . GLU A 1 327 ? 10.770 -41.570 33.386 1.00 22.90 ? 311 GLU A CD 1 ATOM 2300 O OE1 . GLU A 1 327 ? 9.732 -42.242 33.276 1.00 27.10 ? 311 GLU A OE1 1 ATOM 2301 O OE2 . GLU A 1 327 ? 11.759 -41.964 34.028 1.00 23.28 ? 311 GLU A OE2 1 ATOM 2302 N N . VAL A 1 328 ? 12.905 -39.338 35.252 1.00 20.74 ? 312 VAL A N 1 ATOM 2303 C CA . VAL A 1 328 ? 14.310 -38.967 35.409 1.00 18.26 ? 312 VAL A CA 1 ATOM 2304 C C . VAL A 1 328 ? 14.736 -38.182 34.196 1.00 15.62 ? 312 VAL A C 1 ATOM 2305 O O . VAL A 1 328 ? 14.676 -38.696 33.096 1.00 25.72 ? 312 VAL A O 1 ATOM 2306 C CB . VAL A 1 328 ? 15.184 -40.247 35.490 1.00 17.37 ? 312 VAL A CB 1 ATOM 2307 C CG1 . VAL A 1 328 ? 16.683 -39.936 35.385 1.00 17.28 ? 312 VAL A CG1 1 ATOM 2308 C CG2 . VAL A 1 328 ? 14.857 -41.045 36.746 1.00 18.05 ? 312 VAL A CG2 1 ATOM 2309 N N . ALA A 1 329 ? 15.165 -36.941 34.390 1.00 18.36 ? 313 ALA A N 1 ATOM 2310 C CA . ALA A 1 329 ? 15.501 -36.048 33.284 1.00 17.35 ? 313 ALA A CA 1 ATOM 2311 C C . ALA A 1 329 ? 17.007 -36.012 33.073 1.00 15.79 ? 313 ALA A C 1 ATOM 2312 O O . ALA A 1 329 ? 17.762 -36.135 34.014 1.00 19.19 ? 313 ALA A O 1 ATOM 2313 C CB . ALA A 1 329 ? 14.955 -34.653 33.553 1.00 20.25 ? 313 ALA A CB 1 ATOM 2314 N N . GLU A 1 330 ? 17.432 -35.851 31.826 1.00 18.83 ? 314 GLU A N 1 ATOM 2315 C CA . GLU A 1 330 ? 18.848 -35.884 31.453 1.00 16.53 ? 314 GLU A CA 1 ATOM 2316 C C . GLU A 1 330 ? 19.328 -34.503 31.024 1.00 19.42 ? 314 GLU A C 1 ATOM 2317 O O . GLU A 1 330 ? 18.636 -33.817 30.289 1.00 15.89 ? 314 GLU A O 1 ATOM 2318 C CB . GLU A 1 330 ? 19.029 -36.895 30.313 1.00 19.41 ? 314 GLU A CB 1 ATOM 2319 C CG . GLU A 1 330 ? 20.434 -37.105 29.788 1.00 21.42 ? 314 GLU A CG 1 ATOM 2320 C CD . GLU A 1 330 ? 20.518 -38.290 28.833 1.00 26.97 ? 314 GLU A CD 1 ATOM 2321 O OE1 . GLU A 1 330 ? 19.991 -38.203 27.706 1.00 30.81 ? 314 GLU A OE1 1 ATOM 2322 O OE2 . GLU A 1 330 ? 21.110 -39.320 29.214 1.00 30.98 ? 314 GLU A OE2 1 ATOM 2323 N N . THR A 1 331 ? 20.503 -34.085 31.499 1.00 18.75 ? 315 THR A N 1 ATOM 2324 C CA . THR A 1 331 ? 21.108 -32.845 31.008 1.00 17.66 ? 315 THR A CA 1 ATOM 2325 C C . THR A 1 331 ? 22.046 -33.191 29.877 1.00 15.51 ? 315 THR A C 1 ATOM 2326 O O . THR A 1 331 ? 22.278 -34.363 29.586 1.00 17.73 ? 315 THR A O 1 ATOM 2327 C CB . THR A 1 331 ? 21.902 -32.072 32.068 1.00 14.68 ? 315 THR A CB 1 ATOM 2328 O OG1 . THR A 1 331 ? 23.154 -32.714 32.297 1.00 15.08 ? 315 THR A OG1 1 ATOM 2329 C CG2 . THR A 1 331 ? 21.152 -31.997 33.365 1.00 18.47 ? 315 THR A CG2 1 ATOM 2330 N N . GLN A 1 332 ? 22.582 -32.175 29.225 1.00 15.21 ? 316 GLN A N 1 ATOM 2331 C CA . GLN A 1 332 ? 23.450 -32.425 28.098 1.00 15.83 ? 316 GLN A CA 1 ATOM 2332 C C . GLN A 1 332 ? 24.919 -32.431 28.492 1.00 16.57 ? 316 GLN A C 1 ATOM 2333 O O . GLN A 1 332 ? 25.785 -32.518 27.622 1.00 18.39 ? 316 GLN A O 1 ATOM 2334 C CB . GLN A 1 332 ? 23.174 -31.413 26.992 1.00 20.00 ? 316 GLN A CB 1 ATOM 2335 C CG . GLN A 1 332 ? 21.959 -31.774 26.201 1.00 17.94 ? 316 GLN A CG 1 ATOM 2336 C CD . GLN A 1 332 ? 21.978 -33.233 25.802 1.00 24.34 ? 316 GLN A CD 1 ATOM 2337 O OE1 . GLN A 1 332 ? 22.829 -33.679 25.021 1.00 23.00 ? 316 GLN A OE1 1 ATOM 2338 N NE2 . GLN A 1 332 ? 21.053 -33.998 26.363 1.00 25.24 ? 316 GLN A NE2 1 ATOM 2339 N N . HIS A 1 333 ? 25.188 -32.351 29.799 1.00 14.97 ? 317 HIS A N 1 ATOM 2340 C CA . HIS A 1 333 ? 26.560 -32.302 30.317 1.00 14.57 ? 317 HIS A CA 1 ATOM 2341 C C . HIS A 1 333 ? 26.784 -33.359 31.399 1.00 12.47 ? 317 HIS A C 1 ATOM 2342 O O . HIS A 1 333 ? 27.551 -33.170 32.330 1.00 13.49 ? 317 HIS A O 1 ATOM 2343 C CB . HIS A 1 333 ? 26.959 -30.867 30.775 1.00 12.24 ? 317 HIS A CB 1 ATOM 2344 C CG . HIS A 1 333 ? 26.111 -30.299 31.855 1.00 12.12 ? 317 HIS A CG 1 ATOM 2345 N ND1 . HIS A 1 333 ? 26.410 -30.401 33.193 1.00 14.37 ? 317 HIS A ND1 1 ATOM 2346 C CD2 . HIS A 1 333 ? 24.932 -29.601 31.803 1.00 15.51 ? 317 HIS A CD2 1 ATOM 2347 C CE1 . HIS A 1 333 ? 25.479 -29.811 33.913 1.00 15.92 ? 317 HIS A CE1 1 ATOM 2348 N NE2 . HIS A 1 333 ? 24.572 -29.325 33.088 1.00 16.00 ? 317 HIS A NE2 1 ATOM 2349 N N . GLY A 1 334 ? 26.112 -34.491 31.247 1.00 12.86 ? 318 GLY A N 1 ATOM 2350 C CA . GLY A 1 334 ? 26.502 -35.688 31.950 1.00 13.44 ? 318 GLY A CA 1 ATOM 2351 C C . GLY A 1 334 ? 25.852 -35.872 33.293 1.00 10.26 ? 318 GLY A C 1 ATOM 2352 O O . GLY A 1 334 ? 26.307 -36.675 34.072 1.00 12.71 ? 318 GLY A O 1 ATOM 2353 N N . THR A 1 335 ? 24.785 -35.139 33.555 1.00 9.58 ? 319 THR A N 1 ATOM 2354 C CA . THR A 1 335 ? 24.064 -35.295 34.796 1.00 13.10 ? 319 THR A CA 1 ATOM 2355 C C . THR A 1 335 ? 22.639 -35.818 34.527 1.00 12.63 ? 319 THR A C 1 ATOM 2356 O O . THR A 1 335 ? 22.224 -35.903 33.384 1.00 15.14 ? 319 THR A O 1 ATOM 2357 C CB . THR A 1 335 ? 24.035 -33.959 35.579 1.00 11.20 ? 319 THR A CB 1 ATOM 2358 O OG1 . THR A 1 335 ? 23.246 -32.991 34.887 1.00 12.92 ? 319 THR A OG1 1 ATOM 2359 C CG2 . THR A 1 335 ? 25.421 -33.418 35.738 1.00 11.32 ? 319 THR A CG2 1 ATOM 2360 N N . VAL A 1 336 ? 21.926 -36.212 35.583 1.00 11.57 ? 320 VAL A N 1 ATOM 2361 C CA . VAL A 1 336 ? 20.499 -36.508 35.511 1.00 13.63 ? 320 VAL A CA 1 ATOM 2362 C C . VAL A 1 336 ? 19.805 -35.815 36.690 1.00 14.85 ? 320 VAL A C 1 ATOM 2363 O O . VAL A 1 336 ? 20.403 -35.650 37.753 1.00 11.57 ? 320 VAL A O 1 ATOM 2364 C CB . VAL A 1 336 ? 20.193 -38.033 35.561 1.00 13.04 ? 320 VAL A CB 1 ATOM 2365 C CG1 . VAL A 1 336 ? 20.937 -38.773 34.479 1.00 11.42 ? 320 VAL A CG1 1 ATOM 2366 C CG2 . VAL A 1 336 ? 20.530 -38.612 36.918 1.00 12.23 ? 320 VAL A CG2 1 ATOM 2367 N N . LEU A 1 337 ? 18.560 -35.382 36.497 1.00 16.54 ? 321 LEU A N 1 ATOM 2368 C CA A LEU A 1 337 ? 17.803 -34.774 37.587 0.58 13.67 ? 321 LEU A CA 1 ATOM 2369 C CA B LEU A 1 337 ? 17.787 -34.757 37.553 0.42 13.82 ? 321 LEU A CA 1 ATOM 2370 C C . LEU A 1 337 ? 16.716 -35.733 38.000 1.00 13.09 ? 321 LEU A C 1 ATOM 2371 O O . LEU A 1 337 ? 15.983 -36.242 37.176 1.00 12.79 ? 321 LEU A O 1 ATOM 2372 C CB A LEU A 1 337 ? 17.194 -33.423 37.190 0.58 15.55 ? 321 LEU A CB 1 ATOM 2373 C CB B LEU A 1 337 ? 17.145 -33.482 37.018 0.42 15.52 ? 321 LEU A CB 1 ATOM 2374 C CG A LEU A 1 337 ? 16.846 -32.463 38.350 0.58 15.55 ? 321 LEU A CG 1 ATOM 2375 C CG B LEU A 1 337 ? 18.067 -32.651 36.123 0.42 14.74 ? 321 LEU A CG 1 ATOM 2376 C CD1 A LEU A 1 337 ? 16.409 -31.101 37.831 0.58 19.22 ? 321 LEU A CD1 1 ATOM 2377 C CD1 B LEU A 1 337 ? 17.261 -31.757 35.203 0.42 16.45 ? 321 LEU A CD1 1 ATOM 2378 C CD2 A LEU A 1 337 ? 15.769 -32.991 39.277 0.58 15.07 ? 321 LEU A CD2 1 ATOM 2379 C CD2 B LEU A 1 337 ? 19.017 -31.825 36.962 0.42 13.93 ? 321 LEU A CD2 1 ATOM 2380 N N . VAL A 1 338 ? 16.638 -35.987 39.297 1.00 14.12 ? 322 VAL A N 1 ATOM 2381 C CA . VAL A 1 338 ? 15.656 -36.901 39.852 1.00 12.92 ? 322 VAL A CA 1 ATOM 2382 C C . VAL A 1 338 ? 14.827 -36.186 40.890 1.00 12.83 ? 322 VAL A C 1 ATOM 2383 O O . VAL A 1 338 ? 15.354 -35.691 41.857 1.00 13.89 ? 322 VAL A O 1 ATOM 2384 C CB . VAL A 1 338 ? 16.339 -38.092 40.545 1.00 15.42 ? 322 VAL A CB 1 ATOM 2385 C CG1 . VAL A 1 338 ? 15.311 -39.076 41.053 1.00 16.53 ? 322 VAL A CG1 1 ATOM 2386 C CG2 . VAL A 1 338 ? 17.293 -38.784 39.606 1.00 13.05 ? 322 VAL A CG2 1 ATOM 2387 N N . GLN A 1 339 ? 13.519 -36.160 40.704 1.00 14.63 ? 323 GLN A N 1 ATOM 2388 C CA . GLN A 1 339 ? 12.646 -35.579 41.695 1.00 13.91 ? 323 GLN A CA 1 ATOM 2389 C C . GLN A 1 339 ? 11.759 -36.640 42.327 1.00 16.19 ? 323 GLN A C 1 ATOM 2390 O O . GLN A 1 339 ? 11.014 -37.331 41.637 1.00 14.60 ? 323 GLN A O 1 ATOM 2391 C CB . GLN A 1 339 ? 11.782 -34.501 41.070 1.00 17.36 ? 323 GLN A CB 1 ATOM 2392 C CG . GLN A 1 339 ? 11.027 -33.684 42.064 1.00 15.23 ? 323 GLN A CG 1 ATOM 2393 C CD . GLN A 1 339 ? 9.903 -32.942 41.423 1.00 18.11 ? 323 GLN A CD 1 ATOM 2394 O OE1 . GLN A 1 339 ? 8.904 -33.543 41.053 1.00 24.01 ? 323 GLN A OE1 1 ATOM 2395 N NE2 . GLN A 1 339 ? 10.058 -31.631 41.259 1.00 19.42 ? 323 GLN A NE2 1 ATOM 2396 N N . VAL A 1 340 ? 11.831 -36.720 43.655 1.00 16.36 ? 324 VAL A N 1 ATOM 2397 C CA . VAL A 1 340 ? 11.185 -37.769 44.420 1.00 18.49 ? 324 VAL A CA 1 ATOM 2398 C C . VAL A 1 340 ? 10.235 -37.196 45.482 1.00 15.95 ? 324 VAL A C 1 ATOM 2399 O O . VAL A 1 340 ? 10.321 -36.030 45.855 1.00 14.53 ? 324 VAL A O 1 ATOM 2400 C CB . VAL A 1 340 ? 12.248 -38.688 45.082 1.00 12.54 ? 324 VAL A CB 1 ATOM 2401 C CG1 . VAL A 1 340 ? 13.256 -39.121 44.065 1.00 13.76 ? 324 VAL A CG1 1 ATOM 2402 C CG2 . VAL A 1 340 ? 12.954 -37.987 46.226 1.00 13.15 ? 324 VAL A CG2 1 ATOM 2403 N N . LYS A 1 341 ? 9.306 -38.033 45.936 1.00 19.76 ? 325 LYS A N 1 ATOM 2404 C CA . LYS A 1 341 ? 8.407 -37.681 47.029 1.00 19.59 ? 325 LYS A CA 1 ATOM 2405 C C . LYS A 1 341 ? 8.611 -38.701 48.125 1.00 14.96 ? 325 LYS A C 1 ATOM 2406 O O . LYS A 1 341 ? 8.737 -39.884 47.852 1.00 15.47 ? 325 LYS A O 1 ATOM 2407 C CB . LYS A 1 341 ? 6.949 -37.686 46.569 1.00 20.85 ? 325 LYS A CB 1 ATOM 2408 C CG . LYS A 1 341 ? 5.933 -37.265 47.640 1.00 22.09 ? 325 LYS A CG 1 ATOM 2409 C CD . LYS A 1 341 ? 5.206 -35.938 47.314 1.00 28.47 ? 325 LYS A CD 1 ATOM 2410 C CE . LYS A 1 341 ? 3.668 -36.100 47.174 1.00 36.38 ? 325 LYS A CE 1 ATOM 2411 N NZ . LYS A 1 341 ? 3.156 -36.405 45.774 1.00 24.71 ? 325 LYS A NZ 1 ATOM 2412 N N . TYR A 1 342 ? 8.653 -38.229 49.363 1.00 16.42 ? 326 TYR A N 1 ATOM 2413 C CA . TYR A 1 342 ? 8.869 -39.080 50.520 1.00 17.89 ? 326 TYR A CA 1 ATOM 2414 C C . TYR A 1 342 ? 7.549 -39.525 51.111 1.00 18.31 ? 326 TYR A C 1 ATOM 2415 O O . TYR A 1 342 ? 6.611 -38.743 51.207 1.00 21.04 ? 326 TYR A O 1 ATOM 2416 C CB . TYR A 1 342 ? 9.666 -38.318 51.566 1.00 18.18 ? 326 TYR A CB 1 ATOM 2417 C CG . TYR A 1 342 ? 10.072 -39.139 52.762 1.00 15.95 ? 326 TYR A CG 1 ATOM 2418 C CD1 . TYR A 1 342 ? 10.721 -40.348 52.602 1.00 15.36 ? 326 TYR A CD1 1 ATOM 2419 C CD2 . TYR A 1 342 ? 9.832 -38.692 54.049 1.00 18.32 ? 326 TYR A CD2 1 ATOM 2420 C CE1 . TYR A 1 342 ? 11.110 -41.099 53.679 1.00 15.84 ? 326 TYR A CE1 1 ATOM 2421 C CE2 . TYR A 1 342 ? 10.217 -39.445 55.149 1.00 21.49 ? 326 TYR A CE2 1 ATOM 2422 C CZ . TYR A 1 342 ? 10.859 -40.649 54.952 1.00 17.05 ? 326 TYR A CZ 1 ATOM 2423 O OH . TYR A 1 342 ? 11.252 -41.411 56.023 1.00 18.03 ? 326 TYR A OH 1 ATOM 2424 N N . GLU A 1 343 ? 7.494 -40.790 51.509 1.00 22.73 ? 327 GLU A N 1 ATOM 2425 C CA . GLU A 1 343 ? 6.273 -41.404 52.017 1.00 26.29 ? 327 GLU A CA 1 ATOM 2426 C C . GLU A 1 343 ? 6.362 -41.765 53.504 1.00 25.09 ? 327 GLU A C 1 ATOM 2427 O O . GLU A 1 343 ? 5.457 -42.398 54.034 1.00 32.67 ? 327 GLU A O 1 ATOM 2428 C CB . GLU A 1 343 ? 5.972 -42.697 51.243 1.00 30.61 ? 327 GLU A CB 1 ATOM 2429 C CG . GLU A 1 343 ? 5.028 -42.555 50.061 1.00 38.45 ? 327 GLU A CG 1 ATOM 2430 C CD . GLU A 1 343 ? 4.360 -43.885 49.682 1.00 55.25 ? 327 GLU A CD 1 ATOM 2431 O OE1 . GLU A 1 343 ? 4.284 -44.791 50.549 1.00 50.51 ? 327 GLU A OE1 1 ATOM 2432 O OE2 . GLU A 1 343 ? 3.904 -44.023 48.521 1.00 66.79 ? 327 GLU A OE2 1 ATOM 2433 N N . GLY A 1 344 ? 7.436 -41.376 54.179 1.00 21.89 ? 328 GLY A N 1 ATOM 2434 C CA . GLY A 1 344 ? 7.708 -41.871 55.514 1.00 18.32 ? 328 GLY A CA 1 ATOM 2435 C C . GLY A 1 344 ? 7.362 -40.819 56.527 1.00 16.82 ? 328 GLY A C 1 ATOM 2436 O O . GLY A 1 344 ? 6.885 -39.777 56.143 1.00 24.19 ? 328 GLY A O 1 ATOM 2437 N N . THR A 1 345 ? 7.655 -41.069 57.799 1.00 21.13 ? 329 THR A N 1 ATOM 2438 C CA . THR A 1 345 ? 7.138 -40.240 58.895 1.00 24.91 ? 329 THR A CA 1 ATOM 2439 C C . THR A 1 345 ? 8.132 -39.352 59.643 1.00 25.17 ? 329 THR A C 1 ATOM 2440 O O . THR A 1 345 ? 7.743 -38.627 60.571 1.00 25.96 ? 329 THR A O 1 ATOM 2441 C CB . THR A 1 345 ? 6.508 -41.134 59.981 1.00 28.02 ? 329 THR A CB 1 ATOM 2442 O OG1 . THR A 1 345 ? 7.389 -42.227 60.277 1.00 24.86 ? 329 THR A OG1 1 ATOM 2443 C CG2 . THR A 1 345 ? 5.181 -41.665 59.517 1.00 24.32 ? 329 THR A CG2 1 ATOM 2444 N N . ASP A 1 346 ? 9.397 -39.389 59.256 1.00 22.10 ? 330 ASP A N 1 ATOM 2445 C CA . ASP A 1 346 ? 10.435 -38.847 60.112 1.00 17.23 ? 330 ASP A CA 1 ATOM 2446 C C . ASP A 1 346 ? 11.123 -37.603 59.573 1.00 17.80 ? 330 ASP A C 1 ATOM 2447 O O . ASP A 1 346 ? 12.253 -37.330 59.940 1.00 19.51 ? 330 ASP A O 1 ATOM 2448 C CB . ASP A 1 346 ? 11.478 -39.916 60.367 1.00 19.65 ? 330 ASP A CB 1 ATOM 2449 C CG . ASP A 1 346 ? 11.966 -40.551 59.093 1.00 19.19 ? 330 ASP A CG 1 ATOM 2450 O OD1 . ASP A 1 346 ? 11.183 -40.590 58.121 1.00 21.35 ? 330 ASP A OD1 1 ATOM 2451 O OD2 . ASP A 1 346 ? 13.132 -41.002 59.058 1.00 18.97 ? 330 ASP A OD2 1 ATOM 2452 N N . ALA A 1 347 ? 10.449 -36.840 58.727 1.00 21.51 ? 331 ALA A N 1 ATOM 2453 C CA . ALA A 1 347 ? 11.027 -35.609 58.194 1.00 18.13 ? 331 ALA A CA 1 ATOM 2454 C C . ALA A 1 347 ? 11.069 -34.544 59.281 1.00 18.00 ? 331 ALA A C 1 ATOM 2455 O O . ALA A 1 347 ? 10.201 -34.497 60.134 1.00 18.13 ? 331 ALA A O 1 ATOM 2456 C CB . ALA A 1 347 ? 10.223 -35.126 57.009 1.00 22.75 ? 331 ALA A CB 1 ATOM 2457 N N . PRO A 1 348 ? 12.077 -33.667 59.245 1.00 20.71 ? 332 PRO A N 1 ATOM 2458 C CA . PRO A 1 348 ? 13.094 -33.562 58.203 1.00 20.30 ? 332 PRO A CA 1 ATOM 2459 C C . PRO A 1 348 ? 14.184 -34.592 58.365 1.00 14.41 ? 332 PRO A C 1 ATOM 2460 O O . PRO A 1 348 ? 14.580 -34.859 59.487 1.00 17.75 ? 332 PRO A O 1 ATOM 2461 C CB . PRO A 1 348 ? 13.653 -32.157 58.425 1.00 18.24 ? 332 PRO A CB 1 ATOM 2462 C CG . PRO A 1 348 ? 13.576 -31.973 59.872 1.00 18.56 ? 332 PRO A CG 1 ATOM 2463 C CD . PRO A 1 348 ? 12.297 -32.669 60.302 1.00 26.27 ? 332 PRO A CD 1 ATOM 2464 N N . CYS A 1 349 ? 14.652 -35.157 57.256 1.00 17.18 ? 333 CYS A N 1 ATOM 2465 C CA . CYS A 1 349 ? 15.635 -36.236 57.278 1.00 14.29 ? 333 CYS A CA 1 ATOM 2466 C C . CYS A 1 349 ? 16.501 -36.251 56.025 1.00 15.34 ? 333 CYS A C 1 ATOM 2467 O O . CYS A 1 349 ? 16.181 -35.633 55.011 1.00 13.08 ? 333 CYS A O 1 ATOM 2468 C CB . CYS A 1 349 ? 14.958 -37.606 57.462 1.00 13.01 ? 333 CYS A CB 1 ATOM 2469 S SG . CYS A 1 349 ? 13.659 -38.053 56.261 1.00 17.99 ? 333 CYS A SG 1 ATOM 2470 N N . LYS A 1 350 ? 17.608 -36.974 56.109 1.00 17.66 ? 334 LYS A N 1 ATOM 2471 C CA . LYS A 1 350 ? 18.568 -37.041 55.024 1.00 15.58 ? 334 LYS A CA 1 ATOM 2472 C C . LYS A 1 350 ? 18.250 -38.214 54.104 1.00 14.16 ? 334 LYS A C 1 ATOM 2473 O O . LYS A 1 350 ? 18.069 -39.325 54.559 1.00 14.48 ? 334 LYS A O 1 ATOM 2474 C CB . LYS A 1 350 ? 19.972 -37.169 55.608 1.00 16.63 ? 334 LYS A CB 1 ATOM 2475 C CG . LYS A 1 350 ? 21.104 -37.300 54.607 1.00 18.11 ? 334 LYS A CG 1 ATOM 2476 C CD . LYS A 1 350 ? 21.705 -35.951 54.246 1.00 25.55 ? 334 LYS A CD 1 ATOM 2477 C CE . LYS A 1 350 ? 23.204 -36.053 53.958 1.00 32.05 ? 334 LYS A CE 1 ATOM 2478 N NZ . LYS A 1 350 ? 23.747 -34.808 53.326 1.00 36.52 ? 334 LYS A NZ 1 ATOM 2479 N N . ILE A 1 351 ? 18.183 -37.936 52.805 1.00 14.61 ? 335 ILE A N 1 ATOM 2480 C CA . ILE A 1 351 ? 17.816 -38.917 51.788 1.00 16.12 ? 335 ILE A CA 1 ATOM 2481 C C . ILE A 1 351 ? 19.001 -39.795 51.448 1.00 16.77 ? 335 ILE A C 1 ATOM 2482 O O . ILE A 1 351 ? 20.011 -39.306 50.966 1.00 16.68 ? 335 ILE A O 1 ATOM 2483 C CB . ILE A 1 351 ? 17.386 -38.241 50.497 1.00 12.83 ? 335 ILE A CB 1 ATOM 2484 C CG1 . ILE A 1 351 ? 16.150 -37.371 50.723 1.00 12.89 ? 335 ILE A CG1 1 ATOM 2485 C CG2 . ILE A 1 351 ? 17.124 -39.291 49.414 1.00 15.55 ? 335 ILE A CG2 1 ATOM 2486 C CD1 . ILE A 1 351 ? 15.722 -36.604 49.480 1.00 11.22 ? 335 ILE A CD1 1 ATOM 2487 N N . PRO A 1 352 ? 18.882 -41.097 51.713 1.00 14.56 ? 336 PRO A N 1 ATOM 2488 C CA . PRO A 1 352 ? 19.949 -42.034 51.383 1.00 17.31 ? 336 PRO A CA 1 ATOM 2489 C C . PRO A 1 352 ? 20.049 -42.213 49.878 1.00 17.19 ? 336 PRO A C 1 ATOM 2490 O O . PRO A 1 352 ? 19.062 -42.521 49.220 1.00 16.42 ? 336 PRO A O 1 ATOM 2491 C CB . PRO A 1 352 ? 19.494 -43.338 52.050 1.00 15.66 ? 336 PRO A CB 1 ATOM 2492 C CG . PRO A 1 352 ? 18.401 -42.980 52.946 1.00 13.79 ? 336 PRO A CG 1 ATOM 2493 C CD . PRO A 1 352 ? 17.758 -41.770 52.371 1.00 15.16 ? 336 PRO A CD 1 ATOM 2494 N N . PHE A 1 353 ? 21.236 -41.999 49.340 1.00 16.38 ? 337 PHE A N 1 ATOM 2495 C CA . PHE A 1 353 ? 21.435 -42.032 47.912 1.00 20.30 ? 337 PHE A CA 1 ATOM 2496 C C . PHE A 1 353 ? 22.668 -42.831 47.561 1.00 24.54 ? 337 PHE A C 1 ATOM 2497 O O . PHE A 1 353 ? 23.698 -42.769 48.244 1.00 25.07 ? 337 PHE A O 1 ATOM 2498 C CB . PHE A 1 353 ? 21.602 -40.624 47.357 1.00 24.76 ? 337 PHE A CB 1 ATOM 2499 C CG . PHE A 1 353 ? 21.876 -40.593 45.878 1.00 26.24 ? 337 PHE A CG 1 ATOM 2500 C CD1 . PHE A 1 353 ? 23.178 -40.734 45.393 1.00 23.10 ? 337 PHE A CD1 1 ATOM 2501 C CD2 . PHE A 1 353 ? 20.834 -40.432 44.972 1.00 20.18 ? 337 PHE A CD2 1 ATOM 2502 C CE1 . PHE A 1 353 ? 23.432 -40.705 44.027 1.00 21.86 ? 337 PHE A CE1 1 ATOM 2503 C CE2 . PHE A 1 353 ? 21.079 -40.406 43.612 1.00 18.51 ? 337 PHE A CE2 1 ATOM 2504 C CZ . PHE A 1 353 ? 22.384 -40.544 43.139 1.00 21.76 ? 337 PHE A CZ 1 ATOM 2505 N N . SER A 1 354 ? 22.553 -43.562 46.462 1.00 20.65 ? 338 SER A N 1 ATOM 2506 C CA . SER A 1 354 ? 23.612 -44.425 46.010 1.00 19.75 ? 338 SER A CA 1 ATOM 2507 C C . SER A 1 354 ? 23.620 -44.599 44.489 1.00 21.02 ? 338 SER A C 1 ATOM 2508 O O . SER A 1 354 ? 22.606 -44.487 43.812 1.00 17.93 ? 338 SER A O 1 ATOM 2509 C CB . SER A 1 354 ? 23.490 -45.776 46.698 1.00 19.52 ? 338 SER A CB 1 ATOM 2510 O OG . SER A 1 354 ? 24.530 -46.626 46.285 1.00 25.51 ? 338 SER A OG 1 ATOM 2511 N N . SER A 1 355 ? 24.798 -44.877 43.964 1.00 25.60 ? 339 SER A N 1 ATOM 2512 C CA . SER A 1 355 ? 24.965 -45.129 42.559 1.00 18.89 ? 339 SER A CA 1 ATOM 2513 C C . SER A 1 355 ? 25.811 -46.385 42.483 1.00 20.93 ? 339 SER A C 1 ATOM 2514 O O . SER A 1 355 ? 26.759 -46.545 43.250 1.00 20.71 ? 339 SER A O 1 ATOM 2515 C CB . SER A 1 355 ? 25.648 -43.935 41.893 1.00 18.23 ? 339 SER A CB 1 ATOM 2516 O OG . SER A 1 355 ? 26.053 -44.227 40.567 1.00 19.34 ? 339 SER A OG 1 ATOM 2517 N N . GLN A 1 356 ? 25.440 -47.292 41.594 1.00 18.19 ? 340 GLN A N 1 ATOM 2518 C CA . GLN A 1 356 ? 26.191 -48.517 41.403 1.00 23.28 ? 340 GLN A CA 1 ATOM 2519 C C . GLN A 1 356 ? 26.444 -48.673 39.930 1.00 20.79 ? 340 GLN A C 1 ATOM 2520 O O . GLN A 1 356 ? 25.583 -48.350 39.143 1.00 18.24 ? 340 GLN A O 1 ATOM 2521 C CB . GLN A 1 356 ? 25.401 -49.696 41.949 1.00 28.80 ? 340 GLN A CB 1 ATOM 2522 C CG . GLN A 1 356 ? 25.098 -49.564 43.441 1.00 38.44 ? 340 GLN A CG 1 ATOM 2523 C CD . GLN A 1 356 ? 24.093 -50.595 43.946 1.00 48.43 ? 340 GLN A CD 1 ATOM 2524 O OE1 . GLN A 1 356 ? 23.844 -51.615 43.301 1.00 44.69 ? 340 GLN A OE1 1 ATOM 2525 N NE2 . GLN A 1 356 ? 23.504 -50.323 45.107 1.00 48.03 ? 340 GLN A NE2 1 ATOM 2526 N N . ASP A 1 357 ? 27.631 -49.124 39.539 1.00 27.68 ? 341 ASP A N 1 ATOM 2527 C CA . ASP A 1 357 ? 27.951 -49.242 38.114 1.00 30.77 ? 341 ASP A CA 1 ATOM 2528 C C . ASP A 1 357 ? 27.378 -50.554 37.589 1.00 33.41 ? 341 ASP A C 1 ATOM 2529 O O . ASP A 1 357 ? 26.802 -51.322 38.355 1.00 33.35 ? 341 ASP A O 1 ATOM 2530 C CB . ASP A 1 357 ? 29.460 -49.135 37.854 1.00 30.60 ? 341 ASP A CB 1 ATOM 2531 C CG . ASP A 1 357 ? 30.241 -50.263 38.473 1.00 36.34 ? 341 ASP A CG 1 ATOM 2532 O OD1 . ASP A 1 357 ? 29.667 -51.016 39.290 1.00 36.53 ? 341 ASP A OD1 1 ATOM 2533 O OD2 . ASP A 1 357 ? 31.442 -50.387 38.154 1.00 39.07 ? 341 ASP A OD2 1 ATOM 2534 N N . GLU A 1 358 ? 27.516 -50.809 36.291 1.00 34.93 ? 342 GLU A N 1 ATOM 2535 C CA . GLU A 1 358 ? 26.789 -51.926 35.679 1.00 36.58 ? 342 GLU A CA 1 ATOM 2536 C C . GLU A 1 358 ? 26.805 -53.106 36.626 1.00 40.53 ? 342 GLU A C 1 ATOM 2537 O O . GLU A 1 358 ? 25.817 -53.812 36.770 1.00 42.94 ? 342 GLU A O 1 ATOM 2538 C CB . GLU A 1 358 ? 27.336 -52.345 34.297 1.00 36.23 ? 342 GLU A CB 1 ATOM 2539 C CG . GLU A 1 358 ? 28.580 -51.630 33.809 1.00 38.76 ? 342 GLU A CG 1 ATOM 2540 C CD . GLU A 1 358 ? 29.768 -51.873 34.705 1.00 42.17 ? 342 GLU A CD 1 ATOM 2541 O OE1 . GLU A 1 358 ? 29.826 -52.961 35.317 1.00 42.77 ? 342 GLU A OE1 1 ATOM 2542 O OE2 . GLU A 1 358 ? 30.634 -50.973 34.798 1.00 43.87 ? 342 GLU A OE2 1 ATOM 2543 N N . LYS A 1 359 ? 27.932 -53.304 37.293 1.00 46.38 ? 343 LYS A N 1 ATOM 2544 C CA . LYS A 1 359 ? 28.096 -54.461 38.156 1.00 45.33 ? 343 LYS A CA 1 ATOM 2545 C C . LYS A 1 359 ? 28.170 -54.107 39.640 1.00 41.11 ? 343 LYS A C 1 ATOM 2546 O O . LYS A 1 359 ? 29.175 -54.347 40.295 1.00 43.45 ? 343 LYS A O 1 ATOM 2547 C CB . LYS A 1 359 ? 29.317 -55.265 37.706 1.00 47.00 ? 343 LYS A CB 1 ATOM 2548 C CG . LYS A 1 359 ? 29.112 -55.948 36.341 1.00 53.88 ? 343 LYS A CG 1 ATOM 2549 C CD . LYS A 1 359 ? 27.924 -56.930 36.374 1.00 49.12 ? 343 LYS A CD 1 ATOM 2550 C CE . LYS A 1 359 ? 27.657 -57.576 35.028 1.00 36.28 ? 343 LYS A CE 1 ATOM 2551 N NZ . LYS A 1 359 ? 26.438 -58.419 35.101 1.00 40.88 ? 343 LYS A NZ 1 ATOM 2552 N N . GLY A 1 360 ? 27.087 -53.515 40.140 1.00 42.88 ? 344 GLY A N 1 ATOM 2553 C CA . GLY A 1 360 ? 26.806 -53.431 41.564 1.00 37.86 ? 344 GLY A CA 1 ATOM 2554 C C . GLY A 1 360 ? 27.746 -52.649 42.457 1.00 35.24 ? 344 GLY A C 1 ATOM 2555 O O . GLY A 1 360 ? 27.487 -52.533 43.644 1.00 37.68 ? 344 GLY A O 1 ATOM 2556 N N . VAL A 1 361 ? 28.821 -52.100 41.915 1.00 32.40 ? 345 VAL A N 1 ATOM 2557 C CA . VAL A 1 361 ? 29.800 -51.427 42.754 1.00 32.97 ? 345 VAL A CA 1 ATOM 2558 C C . VAL A 1 361 ? 29.241 -50.110 43.259 1.00 30.48 ? 345 VAL A C 1 ATOM 2559 O O . VAL A 1 361 ? 28.986 -49.228 42.461 1.00 29.51 ? 345 VAL A O 1 ATOM 2560 C CB . VAL A 1 361 ? 31.064 -51.087 41.960 1.00 33.55 ? 345 VAL A CB 1 ATOM 2561 C CG1 . VAL A 1 361 ? 32.184 -50.662 42.897 1.00 32.62 ? 345 VAL A CG1 1 ATOM 2562 C CG2 . VAL A 1 361 ? 31.511 -52.271 41.127 1.00 48.54 ? 345 VAL A CG2 1 ATOM 2563 N N . THR A 1 362 ? 29.066 -49.956 44.569 1.00 29.37 ? 346 THR A N 1 ATOM 2564 C CA . THR A 1 362 ? 28.668 -48.659 45.108 1.00 25.76 ? 346 THR A CA 1 ATOM 2565 C C . THR A 1 362 ? 29.818 -47.709 44.878 1.00 22.42 ? 346 THR A C 1 ATOM 2566 O O . THR A 1 362 ? 30.956 -48.088 45.062 1.00 20.39 ? 346 THR A O 1 ATOM 2567 C CB . THR A 1 362 ? 28.373 -48.710 46.608 1.00 32.66 ? 346 THR A CB 1 ATOM 2568 O OG1 . THR A 1 362 ? 27.446 -49.768 46.885 1.00 36.90 ? 346 THR A OG1 1 ATOM 2569 C CG2 . THR A 1 362 ? 27.782 -47.372 47.084 1.00 22.27 ? 346 THR A CG2 1 ATOM 2570 N N . GLN A 1 363 ? 29.519 -46.481 44.461 1.00 22.96 ? 347 GLN A N 1 ATOM 2571 C CA . GLN A 1 363 ? 30.540 -45.553 43.968 1.00 22.35 ? 347 GLN A CA 1 ATOM 2572 C C . GLN A 1 363 ? 30.984 -44.530 45.000 1.00 15.27 ? 347 GLN A C 1 ATOM 2573 O O . GLN A 1 363 ? 31.950 -43.826 44.783 1.00 17.67 ? 347 GLN A O 1 ATOM 2574 C CB . GLN A 1 363 ? 30.032 -44.797 42.737 1.00 19.06 ? 347 GLN A CB 1 ATOM 2575 C CG . GLN A 1 363 ? 29.645 -45.679 41.553 1.00 23.96 ? 347 GLN A CG 1 ATOM 2576 C CD . GLN A 1 363 ? 30.715 -46.684 41.164 1.00 25.98 ? 347 GLN A CD 1 ATOM 2577 O OE1 . GLN A 1 363 ? 31.443 -46.484 40.197 1.00 31.52 ? 347 GLN A OE1 1 ATOM 2578 N NE2 . GLN A 1 363 ? 30.792 -47.780 41.901 1.00 27.26 ? 347 GLN A NE2 1 ATOM 2579 N N . ASN A 1 364 ? 30.276 -44.438 46.109 1.00 17.32 ? 348 ASN A N 1 ATOM 2580 C CA . ASN A 1 364 ? 30.637 -43.504 47.171 1.00 15.51 ? 348 ASN A CA 1 ATOM 2581 C C . ASN A 1 364 ? 30.975 -42.123 46.594 1.00 16.58 ? 348 ASN A C 1 ATOM 2582 O O . ASN A 1 364 ? 32.064 -41.581 46.785 1.00 15.64 ? 348 ASN A O 1 ATOM 2583 C CB . ASN A 1 364 ? 31.772 -44.093 48.012 1.00 16.01 ? 348 ASN A CB 1 ATOM 2584 C CG . ASN A 1 364 ? 31.459 -45.513 48.501 1.00 16.48 ? 348 ASN A CG 1 ATOM 2585 O OD1 . ASN A 1 364 ? 32.134 -46.492 48.160 1.00 19.33 ? 348 ASN A OD1 1 ATOM 2586 N ND2 . ASN A 1 364 ? 30.446 -45.614 49.325 1.00 19.30 ? 348 ASN A ND2 1 ATOM 2587 N N . GLY A 1 365 ? 30.012 -41.556 45.883 1.00 13.24 ? 349 GLY A N 1 ATOM 2588 C CA . GLY A 1 365 ? 30.189 -40.264 45.251 1.00 11.27 ? 349 GLY A CA 1 ATOM 2589 C C . GLY A 1 365 ? 29.139 -40.087 44.188 1.00 11.80 ? 349 GLY A C 1 ATOM 2590 O O . GLY A 1 365 ? 28.124 -40.757 44.223 1.00 11.69 ? 349 GLY A O 1 ATOM 2591 N N . ARG A 1 366 ? 29.384 -39.175 43.256 1.00 10.74 ? 350 ARG A N 1 ATOM 2592 C CA . ARG A 1 366 ? 28.500 -38.945 42.113 1.00 11.25 ? 350 ARG A CA 1 ATOM 2593 C C . ARG A 1 366 ? 27.200 -38.236 42.487 1.00 11.29 ? 350 ARG A C 1 ATOM 2594 O O . ARG A 1 366 ? 26.364 -37.980 41.639 1.00 9.70 ? 350 ARG A O 1 ATOM 2595 C CB . ARG A 1 366 ? 28.198 -40.241 41.348 1.00 8.89 ? 350 ARG A CB 1 ATOM 2596 C CG . ARG A 1 366 ? 29.368 -40.828 40.608 1.00 8.96 ? 350 ARG A CG 1 ATOM 2597 C CD . ARG A 1 366 ? 28.982 -42.113 39.891 1.00 10.72 ? 350 ARG A CD 1 ATOM 2598 N NE . ARG A 1 366 ? 30.108 -42.762 39.239 1.00 9.91 ? 350 ARG A NE 1 ATOM 2599 C CZ . ARG A 1 366 ? 30.680 -42.349 38.113 1.00 9.93 ? 350 ARG A CZ 1 ATOM 2600 N NH1 . ARG A 1 366 ? 30.255 -41.269 37.502 1.00 11.17 ? 350 ARG A NH1 1 ATOM 2601 N NH2 . ARG A 1 366 ? 31.697 -43.015 37.599 1.00 12.71 ? 350 ARG A NH2 1 ATOM 2602 N N . LEU A 1 367 ? 27.038 -37.873 43.745 1.00 10.98 ? 351 LEU A N 1 ATOM 2603 C CA . LEU A 1 367 ? 25.885 -37.081 44.133 1.00 13.11 ? 351 LEU A CA 1 ATOM 2604 C C . LEU A 1 367 ? 26.219 -35.600 43.985 1.00 11.87 ? 351 LEU A C 1 ATOM 2605 O O . LEU A 1 367 ? 27.155 -35.098 44.599 1.00 12.86 ? 351 LEU A O 1 ATOM 2606 C CB . LEU A 1 367 ? 25.480 -37.429 45.564 1.00 14.43 ? 351 LEU A CB 1 ATOM 2607 C CG . LEU A 1 367 ? 24.342 -36.647 46.221 1.00 15.95 ? 351 LEU A CG 1 ATOM 2608 C CD1 . LEU A 1 367 ? 23.092 -36.685 45.385 1.00 12.42 ? 351 LEU A CD1 1 ATOM 2609 C CD2 . LEU A 1 367 ? 24.077 -37.203 47.599 1.00 14.73 ? 351 LEU A CD2 1 ATOM 2610 N N . ILE A 1 368 ? 25.474 -34.892 43.155 1.00 9.64 ? 352 ILE A N 1 ATOM 2611 C CA . ILE A 1 368 ? 25.794 -33.492 42.948 1.00 11.38 ? 352 ILE A CA 1 ATOM 2612 C C . ILE A 1 368 ? 25.088 -32.582 43.961 1.00 15.15 ? 352 ILE A C 1 ATOM 2613 O O . ILE A 1 368 ? 25.699 -31.681 44.541 1.00 15.73 ? 352 ILE A O 1 ATOM 2614 C CB . ILE A 1 368 ? 25.490 -33.070 41.516 1.00 11.34 ? 352 ILE A CB 1 ATOM 2615 C CG1 . ILE A 1 368 ? 26.511 -33.704 40.563 1.00 9.38 ? 352 ILE A CG1 1 ATOM 2616 C CG2 . ILE A 1 368 ? 25.546 -31.572 41.397 1.00 14.09 ? 352 ILE A CG2 1 ATOM 2617 C CD1 . ILE A 1 368 ? 26.093 -33.693 39.128 1.00 11.34 ? 352 ILE A CD1 1 ATOM 2618 N N . THR A 1 369 ? 23.806 -32.816 44.194 1.00 18.10 ? 353 THR A N 1 ATOM 2619 C CA . THR A 1 369 ? 23.059 -32.031 45.182 1.00 17.40 ? 353 THR A CA 1 ATOM 2620 C C . THR A 1 369 ? 23.789 -31.970 46.520 1.00 21.15 ? 353 THR A C 1 ATOM 2621 O O . THR A 1 369 ? 24.233 -32.996 47.050 1.00 21.30 ? 353 THR A O 1 ATOM 2622 C CB . THR A 1 369 ? 21.669 -32.612 45.405 1.00 13.26 ? 353 THR A CB 1 ATOM 2623 O OG1 . THR A 1 369 ? 20.963 -32.599 44.166 1.00 15.90 ? 353 THR A OG1 1 ATOM 2624 C CG2 . THR A 1 369 ? 20.895 -31.792 46.419 1.00 16.42 ? 353 THR A CG2 1 ATOM 2625 N N . ALA A 1 370 ? 23.919 -30.757 47.055 1.00 21.83 ? 354 ALA A N 1 ATOM 2626 C CA . ALA A 1 370 ? 24.594 -30.543 48.322 1.00 20.80 ? 354 ALA A CA 1 ATOM 2627 C C . ALA A 1 370 ? 23.702 -30.989 49.466 1.00 23.32 ? 354 ALA A C 1 ATOM 2628 O O . ALA A 1 370 ? 24.118 -31.780 50.310 1.00 32.61 ? 354 ALA A O 1 ATOM 2629 C CB . ALA A 1 370 ? 24.953 -29.094 48.477 1.00 22.01 ? 354 ALA A CB 1 ATOM 2630 N N . ASN A 1 371 ? 22.468 -30.505 49.481 1.00 22.45 ? 355 ASN A N 1 ATOM 2631 C CA . ASN A 1 371 ? 21.594 -30.719 50.624 1.00 24.08 ? 355 ASN A CA 1 ATOM 2632 C C . ASN A 1 371 ? 20.427 -31.641 50.313 1.00 17.07 ? 355 ASN A C 1 ATOM 2633 O O . ASN A 1 371 ? 19.292 -31.188 50.202 1.00 19.96 ? 355 ASN A O 1 ATOM 2634 C CB . ASN A 1 371 ? 21.106 -29.363 51.112 1.00 24.39 ? 355 ASN A CB 1 ATOM 2635 C CG . ASN A 1 371 ? 22.233 -28.526 51.715 1.00 25.83 ? 355 ASN A CG 1 ATOM 2636 O OD1 . ASN A 1 371 ? 22.603 -27.472 51.187 1.00 24.24 ? 355 ASN A OD1 1 ATOM 2637 N ND2 . ASN A 1 371 ? 22.793 -29.008 52.824 1.00 29.33 ? 355 ASN A ND2 1 ATOM 2638 N N . PRO A 1 372 ? 20.712 -32.947 50.158 1.00 20.33 ? 356 PRO A N 1 ATOM 2639 C CA . PRO A 1 372 ? 19.701 -33.956 49.821 1.00 19.12 ? 356 PRO A CA 1 ATOM 2640 C C . PRO A 1 372 ? 18.768 -34.198 50.988 1.00 14.03 ? 356 PRO A C 1 ATOM 2641 O O . PRO A 1 372 ? 18.791 -35.279 51.555 1.00 16.29 ? 356 PRO A O 1 ATOM 2642 C CB . PRO A 1 372 ? 20.538 -35.208 49.542 1.00 16.03 ? 356 PRO A CB 1 ATOM 2643 C CG . PRO A 1 372 ? 21.759 -35.026 50.335 1.00 20.69 ? 356 PRO A CG 1 ATOM 2644 C CD . PRO A 1 372 ? 22.045 -33.556 50.312 1.00 23.38 ? 356 PRO A CD 1 ATOM 2645 N N . ILE A 1 373 ? 17.980 -33.191 51.353 1.00 18.73 ? 357 ILE A N 1 ATOM 2646 C CA . ILE A 1 373 ? 17.202 -33.229 52.591 1.00 17.83 ? 357 ILE A CA 1 ATOM 2647 C C . ILE A 1 373 ? 15.703 -33.118 52.320 1.00 13.63 ? 357 ILE A C 1 ATOM 2648 O O . ILE A 1 373 ? 15.256 -32.236 51.606 1.00 16.88 ? 357 ILE A O 1 ATOM 2649 C CB . ILE A 1 373 ? 17.601 -32.076 53.557 1.00 14.09 ? 357 ILE A CB 1 ATOM 2650 C CG1 . ILE A 1 373 ? 19.092 -32.100 53.894 1.00 16.19 ? 357 ILE A CG1 1 ATOM 2651 C CG2 . ILE A 1 373 ? 16.793 -32.128 54.827 1.00 13.15 ? 357 ILE A CG2 1 ATOM 2652 C CD1 . ILE A 1 373 ? 19.547 -33.327 54.601 1.00 16.65 ? 357 ILE A CD1 1 ATOM 2653 N N . VAL A 1 374 ? 14.935 -34.028 52.904 1.00 14.67 ? 358 VAL A N 1 ATOM 2654 C CA . VAL A 1 374 ? 13.497 -33.885 52.966 1.00 16.80 ? 358 VAL A CA 1 ATOM 2655 C C . VAL A 1 374 ? 13.223 -32.990 54.154 1.00 17.02 ? 358 VAL A C 1 ATOM 2656 O O . VAL A 1 374 ? 13.335 -33.424 55.289 1.00 19.72 ? 358 VAL A O 1 ATOM 2657 C CB . VAL A 1 374 ? 12.766 -35.245 53.210 1.00 16.03 ? 358 VAL A CB 1 ATOM 2658 C CG1 . VAL A 1 374 ? 11.262 -35.045 53.244 1.00 16.38 ? 358 VAL A CG1 1 ATOM 2659 C CG2 . VAL A 1 374 ? 13.132 -36.271 52.158 1.00 12.69 ? 358 VAL A CG2 1 ATOM 2660 N N . THR A 1 375 ? 12.864 -31.743 53.898 1.00 19.80 ? 359 THR A N 1 ATOM 2661 C CA . THR A 1 375 ? 12.555 -30.811 54.968 1.00 21.83 ? 359 THR A CA 1 ATOM 2662 C C . THR A 1 375 ? 11.054 -30.738 55.172 1.00 22.05 ? 359 THR A C 1 ATOM 2663 O O . THR A 1 375 ? 10.580 -30.282 56.199 1.00 26.47 ? 359 THR A O 1 ATOM 2664 C CB . THR A 1 375 ? 13.071 -29.406 54.644 1.00 22.76 ? 359 THR A CB 1 ATOM 2665 O OG1 . THR A 1 375 ? 12.510 -28.969 53.407 1.00 20.42 ? 359 THR A OG1 1 ATOM 2666 C CG2 . THR A 1 375 ? 14.582 -29.410 54.524 1.00 21.72 ? 359 THR A CG2 1 ATOM 2667 N N . ASP A 1 376 ? 10.318 -31.215 54.181 1.00 21.83 ? 360 ASP A N 1 ATOM 2668 C CA . ASP A 1 376 ? 8.874 -31.127 54.159 1.00 23.07 ? 360 ASP A CA 1 ATOM 2669 C C . ASP A 1 376 ? 8.356 -32.316 53.415 1.00 21.87 ? 360 ASP A C 1 ATOM 2670 O O . ASP A 1 376 ? 8.527 -32.402 52.210 1.00 22.34 ? 360 ASP A O 1 ATOM 2671 C CB . ASP A 1 376 ? 8.424 -29.873 53.419 1.00 26.19 ? 360 ASP A CB 1 ATOM 2672 C CG . ASP A 1 376 ? 6.921 -29.626 53.524 1.00 30.16 ? 360 ASP A CG 1 ATOM 2673 O OD1 . ASP A 1 376 ? 6.167 -30.485 54.034 1.00 27.94 ? 360 ASP A OD1 1 ATOM 2674 O OD2 . ASP A 1 376 ? 6.493 -28.544 53.083 1.00 28.57 ? 360 ASP A OD2 1 ATOM 2675 N N . LYS A 1 377 ? 7.728 -33.231 54.143 1.00 23.71 ? 361 LYS A N 1 ATOM 2676 C CA . LYS A 1 377 ? 7.163 -34.451 53.578 1.00 21.35 ? 361 LYS A CA 1 ATOM 2677 C C . LYS A 1 377 ? 6.265 -34.217 52.352 1.00 22.13 ? 361 LYS A C 1 ATOM 2678 O O . LYS A 1 377 ? 6.211 -35.072 51.470 1.00 23.46 ? 361 LYS A O 1 ATOM 2679 C CB . LYS A 1 377 ? 6.374 -35.197 54.660 1.00 23.31 ? 361 LYS A CB 1 ATOM 2680 C CG . LYS A 1 377 ? 5.847 -36.545 54.212 1.00 24.32 ? 361 LYS A CG 1 ATOM 2681 C CD . LYS A 1 377 ? 4.877 -37.135 55.215 1.00 21.92 ? 361 LYS A CD 1 ATOM 2682 C CE . LYS A 1 377 ? 4.435 -38.534 54.812 1.00 25.12 ? 361 LYS A CE 1 ATOM 2683 N NZ . LYS A 1 377 ? 3.396 -38.545 53.749 1.00 33.06 ? 361 LYS A NZ 1 ATOM 2684 N N . GLU A 1 378 ? 5.578 -33.076 52.280 1.00 20.67 ? 362 GLU A N 1 ATOM 2685 C CA . GLU A 1 378 ? 4.691 -32.795 51.148 1.00 23.81 ? 362 GLU A CA 1 ATOM 2686 C C . GLU A 1 378 ? 5.307 -31.956 50.028 1.00 26.64 ? 362 GLU A C 1 ATOM 2687 O O . GLU A 1 378 ? 4.602 -31.563 49.107 1.00 26.65 ? 362 GLU A O 1 ATOM 2688 C CB . GLU A 1 378 ? 3.407 -32.112 51.615 1.00 29.80 ? 362 GLU A CB 1 ATOM 2689 C CG . GLU A 1 378 ? 2.152 -32.768 51.050 1.00 36.21 ? 362 GLU A CG 1 ATOM 2690 C CD . GLU A 1 378 ? 1.794 -34.057 51.766 1.00 32.04 ? 362 GLU A CD 1 ATOM 2691 O OE1 . GLU A 1 378 ? 1.681 -35.115 51.106 1.00 39.18 ? 362 GLU A OE1 1 ATOM 2692 O OE2 . GLU A 1 378 ? 1.619 -34.013 52.996 1.00 25.40 ? 362 GLU A OE2 1 ATOM 2693 N N . LYS A 1 379 ? 6.605 -31.669 50.110 1.00 25.22 ? 363 LYS A N 1 ATOM 2694 C CA . LYS A 1 379 ? 7.320 -31.059 48.994 1.00 22.59 ? 363 LYS A CA 1 ATOM 2695 C C . LYS A 1 379 ? 8.201 -32.098 48.346 1.00 20.79 ? 363 LYS A C 1 ATOM 2696 O O . LYS A 1 379 ? 8.892 -32.838 49.042 1.00 18.59 ? 363 LYS A O 1 ATOM 2697 C CB . LYS A 1 379 ? 8.206 -29.919 49.468 1.00 26.41 ? 363 LYS A CB 1 ATOM 2698 C CG . LYS A 1 379 ? 7.517 -28.979 50.387 1.00 28.53 ? 363 LYS A CG 1 ATOM 2699 C CD . LYS A 1 379 ? 6.283 -28.420 49.740 1.00 30.77 ? 363 LYS A CD 1 ATOM 2700 C CE . LYS A 1 379 ? 5.721 -27.254 50.535 1.00 37.84 ? 363 LYS A CE 1 ATOM 2701 N NZ . LYS A 1 379 ? 6.751 -26.196 50.748 1.00 49.36 ? 363 LYS A NZ 1 ATOM 2702 N N . PRO A 1 380 ? 8.176 -32.171 47.008 1.00 24.47 ? 364 PRO A N 1 ATOM 2703 C CA . PRO A 1 380 ? 9.105 -33.085 46.333 1.00 21.34 ? 364 PRO A CA 1 ATOM 2704 C C . PRO A 1 380 ? 10.540 -32.577 46.442 1.00 13.95 ? 364 PRO A C 1 ATOM 2705 O O . PRO A 1 380 ? 10.719 -31.364 46.601 1.00 20.51 ? 364 PRO A O 1 ATOM 2706 C CB . PRO A 1 380 ? 8.621 -33.067 44.879 1.00 21.47 ? 364 PRO A CB 1 ATOM 2707 C CG . PRO A 1 380 ? 7.241 -32.524 44.924 1.00 19.33 ? 364 PRO A CG 1 ATOM 2708 C CD . PRO A 1 380 ? 7.206 -31.582 46.067 1.00 20.53 ? 364 PRO A CD 1 ATOM 2709 N N . VAL A 1 381 ? 11.524 -33.474 46.370 1.00 14.26 ? 365 VAL A N 1 ATOM 2710 C CA . VAL A 1 381 ? 12.942 -33.099 46.473 1.00 14.84 ? 365 VAL A CA 1 ATOM 2711 C C . VAL A 1 381 ? 13.695 -33.383 45.175 1.00 12.38 ? 365 VAL A C 1 ATOM 2712 O O . VAL A 1 381 ? 13.691 -34.490 44.689 1.00 11.55 ? 365 VAL A O 1 ATOM 2713 C CB . VAL A 1 381 ? 13.647 -33.840 47.655 1.00 13.76 ? 365 VAL A CB 1 ATOM 2714 C CG1 . VAL A 1 381 ? 15.088 -33.337 47.864 1.00 12.55 ? 365 VAL A CG1 1 ATOM 2715 C CG2 . VAL A 1 381 ? 12.867 -33.655 48.928 1.00 14.43 ? 365 VAL A CG2 1 ATOM 2716 N N . ASN A 1 382 ? 14.337 -32.365 44.621 1.00 17.50 ? 366 ASN A N 1 ATOM 2717 C CA . ASN A 1 382 ? 15.143 -32.529 43.417 1.00 17.46 ? 366 ASN A CA 1 ATOM 2718 C C . ASN A 1 382 ? 16.522 -32.988 43.788 1.00 16.04 ? 366 ASN A C 1 ATOM 2719 O O . ASN A 1 382 ? 17.153 -32.431 44.685 1.00 17.12 ? 366 ASN A O 1 ATOM 2720 C CB . ASN A 1 382 ? 15.282 -31.209 42.663 1.00 15.46 ? 366 ASN A CB 1 ATOM 2721 C CG . ASN A 1 382 ? 13.968 -30.697 42.155 1.00 18.63 ? 366 ASN A CG 1 ATOM 2722 O OD1 . ASN A 1 382 ? 13.247 -31.410 41.463 1.00 19.52 ? 366 ASN A OD1 1 ATOM 2723 N ND2 . ASN A 1 382 ? 13.644 -29.460 42.492 1.00 17.92 ? 366 ASN A ND2 1 ATOM 2724 N N . ILE A 1 383 ? 16.987 -34.002 43.087 1.00 14.02 ? 367 ILE A N 1 ATOM 2725 C CA . ILE A 1 383 ? 18.312 -34.539 43.297 1.00 14.43 ? 367 ILE A CA 1 ATOM 2726 C C . ILE A 1 383 ? 19.027 -34.579 41.952 1.00 14.25 ? 367 ILE A C 1 ATOM 2727 O O . ILE A 1 383 ? 18.502 -35.125 40.990 1.00 16.43 ? 367 ILE A O 1 ATOM 2728 C CB . ILE A 1 383 ? 18.250 -35.963 43.857 1.00 14.90 ? 367 ILE A CB 1 ATOM 2729 C CG1 . ILE A 1 383 ? 17.500 -35.978 45.177 1.00 17.40 ? 367 ILE A CG1 1 ATOM 2730 C CG2 . ILE A 1 383 ? 19.643 -36.510 44.053 1.00 19.31 ? 367 ILE A CG2 1 ATOM 2731 C CD1 . ILE A 1 383 ? 16.963 -37.334 45.551 1.00 19.88 ? 367 ILE A CD1 1 ATOM 2732 N N . GLU A 1 384 ? 20.222 -34.000 41.881 1.00 16.37 ? 368 GLU A N 1 ATOM 2733 C CA . GLU A 1 384 ? 21.057 -34.120 40.693 1.00 13.90 ? 368 GLU A CA 1 ATOM 2734 C C . GLU A 1 384 ? 22.254 -35.011 40.970 1.00 10.47 ? 368 GLU A C 1 ATOM 2735 O O . GLU A 1 384 ? 22.920 -34.893 41.997 1.00 12.19 ? 368 GLU A O 1 ATOM 2736 C CB . GLU A 1 384 ? 21.556 -32.755 40.200 1.00 16.48 ? 368 GLU A CB 1 ATOM 2737 C CG . GLU A 1 384 ? 20.491 -31.678 40.101 1.00 20.38 ? 368 GLU A CG 1 ATOM 2738 C CD . GLU A 1 384 ? 21.045 -30.377 39.527 1.00 21.46 ? 368 GLU A CD 1 ATOM 2739 O OE1 . GLU A 1 384 ? 22.145 -30.435 38.949 1.00 20.50 ? 368 GLU A OE1 1 ATOM 2740 O OE2 . GLU A 1 384 ? 20.391 -29.310 39.646 1.00 30.10 ? 368 GLU A OE2 1 ATOM 2741 N N . ALA A 1 385 ? 22.519 -35.905 40.038 1.00 10.33 ? 369 ALA A N 1 ATOM 2742 C CA . ALA A 1 385 ? 23.603 -36.857 40.181 1.00 13.05 ? 369 ALA A CA 1 ATOM 2743 C C . ALA A 1 385 ? 24.271 -37.112 38.830 1.00 8.73 ? 369 ALA A C 1 ATOM 2744 O O . ALA A 1 385 ? 23.707 -36.827 37.786 1.00 7.44 ? 369 ALA A O 1 ATOM 2745 C CB . ALA A 1 385 ? 23.082 -38.150 40.792 1.00 10.17 ? 369 ALA A CB 1 ATOM 2746 N N . GLU A 1 386 ? 25.484 -37.645 38.873 1.00 8.07 ? 370 GLU A N 1 ATOM 2747 C CA . GLU A 1 386 ? 26.297 -37.830 37.690 1.00 8.77 ? 370 GLU A CA 1 ATOM 2748 C C . GLU A 1 386 ? 26.689 -39.307 37.558 1.00 11.03 ? 370 GLU A C 1 ATOM 2749 O O . GLU A 1 386 ? 27.722 -39.714 38.085 1.00 13.94 ? 370 GLU A O 1 ATOM 2750 C CB . GLU A 1 386 ? 27.538 -36.934 37.818 1.00 9.14 ? 370 GLU A CB 1 ATOM 2751 C CG . GLU A 1 386 ? 28.569 -37.109 36.741 1.00 13.19 ? 370 GLU A CG 1 ATOM 2752 C CD . GLU A 1 386 ? 29.733 -36.154 36.877 1.00 12.19 ? 370 GLU A CD 1 ATOM 2753 O OE1 . GLU A 1 386 ? 30.462 -35.989 35.880 1.00 11.78 ? 370 GLU A OE1 1 ATOM 2754 O OE2 . GLU A 1 386 ? 29.915 -35.590 37.976 1.00 9.90 ? 370 GLU A OE2 1 ATOM 2755 N N . PRO A 1 387 ? 25.859 -40.121 36.867 1.00 9.79 ? 371 PRO A N 1 ATOM 2756 C CA . PRO A 1 387 ? 26.079 -41.552 36.610 1.00 8.76 ? 371 PRO A CA 1 ATOM 2757 C C . PRO A 1 387 ? 27.355 -41.882 35.854 1.00 8.60 ? 371 PRO A C 1 ATOM 2758 O O . PRO A 1 387 ? 27.773 -41.110 35.009 1.00 10.64 ? 371 PRO A O 1 ATOM 2759 C CB . PRO A 1 387 ? 24.895 -41.932 35.704 1.00 7.50 ? 371 PRO A CB 1 ATOM 2760 C CG . PRO A 1 387 ? 23.907 -40.938 35.903 1.00 9.93 ? 371 PRO A CG 1 ATOM 2761 C CD . PRO A 1 387 ? 24.605 -39.658 36.249 1.00 10.08 ? 371 PRO A CD 1 ATOM 2762 N N . PRO A 1 388 ? 27.930 -43.063 36.105 1.00 10.01 ? 372 PRO A N 1 ATOM 2763 C CA . PRO A 1 388 ? 29.028 -43.548 35.278 1.00 9.24 ? 372 PRO A CA 1 ATOM 2764 C C . PRO A 1 388 ? 28.568 -43.629 33.863 1.00 9.02 ? 372 PRO A C 1 ATOM 2765 O O . PRO A 1 388 ? 27.376 -43.729 33.635 1.00 12.71 ? 372 PRO A O 1 ATOM 2766 C CB . PRO A 1 388 ? 29.263 -44.979 35.781 1.00 11.11 ? 372 PRO A CB 1 ATOM 2767 C CG . PRO A 1 388 ? 28.526 -45.115 37.020 1.00 13.93 ? 372 PRO A CG 1 ATOM 2768 C CD . PRO A 1 388 ? 27.443 -44.087 37.037 1.00 11.30 ? 372 PRO A CD 1 ATOM 2769 N N . PHE A 1 389 ? 29.482 -43.621 32.913 1.00 10.02 ? 373 PHE A N 1 ATOM 2770 C CA . PHE A 1 389 ? 29.107 -43.917 31.551 1.00 10.67 ? 373 PHE A CA 1 ATOM 2771 C C . PHE A 1 389 ? 28.664 -45.376 31.433 1.00 12.17 ? 373 PHE A C 1 ATOM 2772 O O . PHE A 1 389 ? 29.129 -46.233 32.179 1.00 13.49 ? 373 PHE A O 1 ATOM 2773 C CB . PHE A 1 389 ? 30.275 -43.643 30.642 1.00 13.08 ? 373 PHE A CB 1 ATOM 2774 C CG . PHE A 1 389 ? 30.469 -42.202 30.368 1.00 11.76 ? 373 PHE A CG 1 ATOM 2775 C CD1 . PHE A 1 389 ? 29.714 -41.581 29.411 1.00 11.66 ? 373 PHE A CD1 1 ATOM 2776 C CD2 . PHE A 1 389 ? 31.392 -41.463 31.069 1.00 11.57 ? 373 PHE A CD2 1 ATOM 2777 C CE1 . PHE A 1 389 ? 29.883 -40.255 29.151 1.00 11.54 ? 373 PHE A CE1 1 ATOM 2778 C CE2 . PHE A 1 389 ? 31.551 -40.129 30.814 1.00 10.27 ? 373 PHE A CE2 1 ATOM 2779 C CZ . PHE A 1 389 ? 30.807 -39.530 29.845 1.00 9.76 ? 373 PHE A CZ 1 ATOM 2780 N N . GLY A 1 390 ? 27.757 -45.654 30.504 1.00 12.39 ? 374 GLY A N 1 ATOM 2781 C CA . GLY A 1 390 ? 27.271 -47.013 30.299 1.00 12.72 ? 374 GLY A CA 1 ATOM 2782 C C . GLY A 1 390 ? 26.072 -47.340 31.173 1.00 11.12 ? 374 GLY A C 1 ATOM 2783 O O . GLY A 1 390 ? 25.342 -46.444 31.557 1.00 10.98 ? 374 GLY A O 1 ATOM 2784 N N . GLU A 1 391 ? 25.887 -48.619 31.507 1.00 18.31 ? 375 GLU A N 1 ATOM 2785 C CA . GLU A 1 391 ? 24.813 -49.065 32.417 1.00 16.20 ? 375 GLU A CA 1 ATOM 2786 C C . GLU A 1 391 ? 25.139 -48.878 33.907 1.00 14.93 ? 375 GLU A C 1 ATOM 2787 O O . GLU A 1 391 ? 26.235 -49.174 34.360 1.00 18.59 ? 375 GLU A O 1 ATOM 2788 C CB . GLU A 1 391 ? 24.503 -50.539 32.159 1.00 17.48 ? 375 GLU A CB 1 ATOM 2789 C CG . GLU A 1 391 ? 23.315 -50.777 31.246 1.00 23.00 ? 375 GLU A CG 1 ATOM 2790 C CD . GLU A 1 391 ? 21.978 -50.576 31.963 1.00 20.90 ? 375 GLU A CD 1 ATOM 2791 O OE1 . GLU A 1 391 ? 20.973 -50.216 31.302 1.00 22.15 ? 375 GLU A OE1 1 ATOM 2792 O OE2 . GLU A 1 391 ? 21.935 -50.787 33.192 1.00 26.54 ? 375 GLU A OE2 1 ATOM 2793 N N . SER A 1 392 ? 24.169 -48.394 34.667 1.00 14.78 ? 376 SER A N 1 ATOM 2794 C CA . SER A 1 392 ? 24.350 -48.188 36.094 1.00 13.83 ? 376 SER A CA 1 ATOM 2795 C C . SER A 1 392 ? 22.996 -48.203 36.770 1.00 15.53 ? 376 SER A C 1 ATOM 2796 O O . SER A 1 392 ? 21.971 -48.305 36.109 1.00 13.94 ? 376 SER A O 1 ATOM 2797 C CB . SER A 1 392 ? 25.064 -46.853 36.374 1.00 16.57 ? 376 SER A CB 1 ATOM 2798 O OG . SER A 1 392 ? 24.234 -45.727 36.121 1.00 15.50 ? 376 SER A OG 1 ATOM 2799 N N . TYR A 1 393 ? 22.999 -48.092 38.094 1.00 20.82 ? 377 TYR A N 1 ATOM 2800 C CA . TYR A 1 393 ? 21.768 -48.020 38.874 1.00 18.53 ? 377 TYR A CA 1 ATOM 2801 C C . TYR A 1 393 ? 21.774 -46.827 39.834 1.00 14.51 ? 377 TYR A C 1 ATOM 2802 O O . TYR A 1 393 ? 22.785 -46.512 40.431 1.00 15.40 ? 377 TYR A O 1 ATOM 2803 C CB . TYR A 1 393 ? 21.569 -49.321 39.642 1.00 20.51 ? 377 TYR A CB 1 ATOM 2804 C CG . TYR A 1 393 ? 21.644 -50.533 38.746 1.00 23.37 ? 377 TYR A CG 1 ATOM 2805 C CD1 . TYR A 1 393 ? 20.523 -51.010 38.086 1.00 25.37 ? 377 TYR A CD1 1 ATOM 2806 C CD2 . TYR A 1 393 ? 22.843 -51.185 38.543 1.00 27.77 ? 377 TYR A CD2 1 ATOM 2807 C CE1 . TYR A 1 393 ? 20.602 -52.104 37.257 1.00 27.52 ? 377 TYR A CE1 1 ATOM 2808 C CE2 . TYR A 1 393 ? 22.927 -52.279 37.720 1.00 31.70 ? 377 TYR A CE2 1 ATOM 2809 C CZ . TYR A 1 393 ? 21.808 -52.734 37.077 1.00 32.33 ? 377 TYR A CZ 1 ATOM 2810 O OH . TYR A 1 393 ? 21.913 -53.834 36.257 1.00 42.88 ? 377 TYR A OH 1 ATOM 2811 N N . ILE A 1 394 ? 20.644 -46.136 39.937 1.00 15.90 ? 378 ILE A N 1 ATOM 2812 C CA . ILE A 1 394 ? 20.472 -45.068 40.917 1.00 17.80 ? 378 ILE A CA 1 ATOM 2813 C C . ILE A 1 394 ? 19.602 -45.626 42.040 1.00 20.84 ? 378 ILE A C 1 ATOM 2814 O O . ILE A 1 394 ? 18.620 -46.313 41.768 1.00 26.15 ? 378 ILE A O 1 ATOM 2815 C CB . ILE A 1 394 ? 19.801 -43.836 40.301 1.00 19.74 ? 378 ILE A CB 1 ATOM 2816 C CG1 . ILE A 1 394 ? 20.720 -43.195 39.254 1.00 26.15 ? 378 ILE A CG1 1 ATOM 2817 C CG2 . ILE A 1 394 ? 19.470 -42.831 41.391 1.00 24.40 ? 378 ILE A CG2 1 ATOM 2818 C CD1 . ILE A 1 394 ? 19.994 -42.623 38.037 1.00 21.59 ? 378 ILE A CD1 1 ATOM 2819 N N . VAL A 1 395 ? 19.969 -45.372 43.293 1.00 20.13 ? 379 VAL A N 1 ATOM 2820 C CA . VAL A 1 395 ? 19.209 -45.896 44.437 1.00 20.05 ? 379 VAL A CA 1 ATOM 2821 C C . VAL A 1 395 ? 18.906 -44.837 45.487 1.00 17.84 ? 379 VAL A C 1 ATOM 2822 O O . VAL A 1 395 ? 19.806 -44.317 46.139 1.00 20.45 ? 379 VAL A O 1 ATOM 2823 C CB . VAL A 1 395 ? 19.960 -47.024 45.153 1.00 19.14 ? 379 VAL A CB 1 ATOM 2824 C CG1 . VAL A 1 395 ? 19.102 -47.635 46.235 1.00 17.52 ? 379 VAL A CG1 1 ATOM 2825 C CG2 . VAL A 1 395 ? 20.408 -48.075 44.164 1.00 27.66 ? 379 VAL A CG2 1 ATOM 2826 N N . VAL A 1 396 ? 17.627 -44.552 45.680 1.00 17.39 ? 380 VAL A N 1 ATOM 2827 C CA . VAL A 1 396 ? 17.221 -43.615 46.723 1.00 19.36 ? 380 VAL A CA 1 ATOM 2828 C C . VAL A 1 396 ? 16.387 -44.316 47.827 1.00 18.96 ? 380 VAL A C 1 ATOM 2829 O O . VAL A 1 396 ? 15.467 -45.085 47.551 1.00 15.45 ? 380 VAL A O 1 ATOM 2830 C CB . VAL A 1 396 ? 16.550 -42.330 46.103 1.00 17.60 ? 380 VAL A CB 1 ATOM 2831 C CG1 . VAL A 1 396 ? 16.069 -42.585 44.673 1.00 18.19 ? 380 VAL A CG1 1 ATOM 2832 C CG2 . VAL A 1 396 ? 15.442 -41.771 46.985 1.00 17.78 ? 380 VAL A CG2 1 ATOM 2833 N N . GLY A 1 397 ? 16.766 -44.083 49.078 1.00 15.09 ? 381 GLY A N 1 ATOM 2834 C CA . GLY A 1 397 ? 16.164 -44.775 50.195 1.00 17.23 ? 381 GLY A CA 1 ATOM 2835 C C . GLY A 1 397 ? 17.024 -45.924 50.652 1.00 14.64 ? 381 GLY A C 1 ATOM 2836 O O . GLY A 1 397 ? 17.921 -46.336 49.945 1.00 17.23 ? 381 GLY A O 1 ATOM 2837 N N . ALA A 1 398 ? 16.749 -46.441 51.842 1.00 18.17 ? 382 ALA A N 1 ATOM 2838 C CA . ALA A 1 398 ? 17.567 -47.497 52.416 1.00 21.15 ? 382 ALA A CA 1 ATOM 2839 C C . ALA A 1 398 ? 16.815 -48.803 52.507 1.00 23.67 ? 382 ALA A C 1 ATOM 2840 O O . ALA A 1 398 ? 15.604 -48.805 52.706 1.00 26.74 ? 382 ALA A O 1 ATOM 2841 C CB . ALA A 1 398 ? 18.047 -47.095 53.787 1.00 28.07 ? 382 ALA A CB 1 ATOM 2842 N N . GLY A 1 399 ? 17.547 -49.908 52.355 1.00 21.80 ? 383 GLY A N 1 ATOM 2843 C CA . GLY A 1 399 ? 17.000 -51.247 52.506 1.00 26.30 ? 383 GLY A CA 1 ATOM 2844 C C . GLY A 1 399 ? 16.172 -51.744 51.338 1.00 32.74 ? 383 GLY A C 1 ATOM 2845 O O . GLY A 1 399 ? 16.459 -51.438 50.182 1.00 31.26 ? 383 GLY A O 1 ATOM 2846 N N . GLU A 1 400 ? 15.132 -52.516 51.664 1.00 38.82 ? 384 GLU A N 1 ATOM 2847 C CA . GLU A 1 400 ? 14.241 -53.130 50.679 1.00 33.66 ? 384 GLU A CA 1 ATOM 2848 C C . GLU A 1 400 ? 13.208 -52.124 50.243 1.00 29.21 ? 384 GLU A C 1 ATOM 2849 O O . GLU A 1 400 ? 12.579 -52.275 49.203 1.00 32.28 ? 384 GLU A O 1 ATOM 2850 C CB . GLU A 1 400 ? 13.485 -54.311 51.284 1.00 42.14 ? 384 GLU A CB 1 ATOM 2851 C CG . GLU A 1 400 ? 14.269 -55.173 52.273 1.00 40.27 ? 384 GLU A CG 1 ATOM 2852 C CD . GLU A 1 400 ? 13.354 -55.831 53.291 1.00 38.92 ? 384 GLU A CD 1 ATOM 2853 O OE1 . GLU A 1 400 ? 12.190 -56.097 52.930 1.00 33.62 ? 384 GLU A OE1 1 ATOM 2854 O OE2 . GLU A 1 400 ? 13.787 -56.062 54.444 1.00 42.88 ? 384 GLU A OE2 1 ATOM 2855 N N . LYS A 1 401 ? 13.022 -51.109 51.075 1.00 29.94 ? 385 LYS A N 1 ATOM 2856 C CA . LYS A 1 401 ? 12.126 -50.011 50.770 1.00 32.59 ? 385 LYS A CA 1 ATOM 2857 C C . LYS A 1 401 ? 12.702 -49.107 49.666 1.00 36.25 ? 385 LYS A C 1 ATOM 2858 O O . LYS A 1 401 ? 12.068 -48.116 49.266 1.00 39.09 ? 385 LYS A O 1 ATOM 2859 C CB . LYS A 1 401 ? 11.868 -49.202 52.044 1.00 34.16 ? 385 LYS A CB 1 ATOM 2860 C CG . LYS A 1 401 ? 10.823 -48.113 51.895 1.00 30.73 ? 385 LYS A CG 1 ATOM 2861 C CD . LYS A 1 401 ? 9.484 -48.511 52.497 1.00 36.65 ? 385 LYS A CD 1 ATOM 2862 C CE . LYS A 1 401 ? 9.532 -48.618 54.026 1.00 34.30 ? 385 LYS A CE 1 ATOM 2863 N NZ . LYS A 1 401 ? 8.174 -48.493 54.631 1.00 40.87 ? 385 LYS A NZ 1 ATOM 2864 N N . ALA A 1 402 ? 13.893 -49.445 49.168 1.00 27.30 ? 386 ALA A N 1 ATOM 2865 C CA . ALA A 1 402 ? 14.595 -48.584 48.217 1.00 24.10 ? 386 ALA A CA 1 ATOM 2866 C C . ALA A 1 402 ? 14.032 -48.612 46.787 1.00 18.60 ? 386 ALA A C 1 ATOM 2867 O O . ALA A 1 402 ? 13.611 -49.641 46.291 1.00 25.04 ? 386 ALA A O 1 ATOM 2868 C CB . ALA A 1 402 ? 16.065 -48.920 48.209 1.00 19.16 ? 386 ALA A CB 1 ATOM 2869 N N . LEU A 1 403 ? 14.040 -47.441 46.157 1.00 22.00 ? 387 LEU A N 1 ATOM 2870 C CA . LEU A 1 403 ? 13.684 -47.235 44.758 1.00 20.79 ? 387 LEU A CA 1 ATOM 2871 C C . LEU A 1 403 ? 14.921 -47.488 43.924 1.00 23.14 ? 387 LEU A C 1 ATOM 2872 O O . LEU A 1 403 ? 15.895 -46.754 44.053 1.00 23.36 ? 387 LEU A O 1 ATOM 2873 C CB . LEU A 1 403 ? 13.283 -45.776 44.556 1.00 21.99 ? 387 LEU A CB 1 ATOM 2874 C CG . LEU A 1 403 ? 11.905 -45.418 44.005 1.00 30.40 ? 387 LEU A CG 1 ATOM 2875 C CD1 . LEU A 1 403 ? 11.699 -43.913 44.075 1.00 24.17 ? 387 LEU A CD1 1 ATOM 2876 C CD2 . LEU A 1 403 ? 11.755 -45.920 42.580 1.00 31.63 ? 387 LEU A CD2 1 ATOM 2877 N N . LYS A 1 404 ? 14.891 -48.507 43.066 1.00 28.04 ? 388 LYS A N 1 ATOM 2878 C CA . LYS A 1 404 ? 16.061 -48.896 42.260 1.00 28.54 ? 388 LYS A CA 1 ATOM 2879 C C . LYS A 1 404 ? 15.789 -48.663 40.768 1.00 30.84 ? 388 LYS A C 1 ATOM 2880 O O . LYS A 1 404 ? 14.827 -49.208 40.203 1.00 24.79 ? 388 LYS A O 1 ATOM 2881 C CB . LYS A 1 404 ? 16.419 -50.367 42.543 1.00 25.66 ? 388 LYS A CB 1 ATOM 2882 C CG . LYS A 1 404 ? 17.720 -50.903 41.930 1.00 26.91 ? 388 LYS A CG 1 ATOM 2883 C CD . LYS A 1 404 ? 18.155 -52.208 42.657 1.00 47.41 ? 388 LYS A CD 1 ATOM 2884 C CE . LYS A 1 404 ? 18.992 -53.165 41.786 1.00 53.50 ? 388 LYS A CE 1 ATOM 2885 N NZ . LYS A 1 404 ? 19.286 -54.472 42.481 1.00 53.07 ? 388 LYS A NZ 1 ATOM 2886 N N . LEU A 1 405 ? 16.629 -47.843 40.140 1.00 23.83 ? 389 LEU A N 1 ATOM 2887 C CA . LEU A 1 405 ? 16.403 -47.429 38.758 1.00 27.33 ? 389 LEU A CA 1 ATOM 2888 C C . LEU A 1 405 ? 17.626 -47.714 37.919 1.00 23.50 ? 389 LEU A C 1 ATOM 2889 O O . LEU A 1 405 ? 18.711 -47.327 38.288 1.00 25.35 ? 389 LEU A O 1 ATOM 2890 C CB . LEU A 1 405 ? 16.107 -45.930 38.701 1.00 25.41 ? 389 LEU A CB 1 ATOM 2891 C CG . LEU A 1 405 ? 14.988 -45.514 37.745 1.00 33.59 ? 389 LEU A CG 1 ATOM 2892 C CD1 . LEU A 1 405 ? 14.086 -44.512 38.462 1.00 34.68 ? 389 LEU A CD1 1 ATOM 2893 C CD2 . LEU A 1 405 ? 15.523 -44.939 36.431 1.00 27.43 ? 389 LEU A CD2 1 ATOM 2894 N N . SER A 1 406 ? 17.457 -48.372 36.780 1.00 26.53 ? 390 SER A N 1 ATOM 2895 C CA . SER A 1 406 ? 18.593 -48.644 35.903 1.00 21.46 ? 390 SER A CA 1 ATOM 2896 C C . SER A 1 406 ? 18.735 -47.507 34.911 1.00 20.94 ? 390 SER A C 1 ATOM 2897 O O . SER A 1 406 ? 17.746 -46.968 34.435 1.00 22.94 ? 390 SER A O 1 ATOM 2898 C CB . SER A 1 406 ? 18.416 -49.966 35.172 1.00 21.97 ? 390 SER A CB 1 ATOM 2899 O OG . SER A 1 406 ? 17.173 -49.989 34.505 1.00 34.54 ? 390 SER A OG 1 ATOM 2900 N N . TRP A 1 407 ? 19.977 -47.145 34.613 1.00 20.91 ? 391 TRP A N 1 ATOM 2901 C CA . TRP A 1 407 ? 20.280 -46.015 33.744 1.00 14.98 ? 391 TRP A CA 1 ATOM 2902 C C . TRP A 1 407 ? 21.330 -46.389 32.705 1.00 12.86 ? 391 TRP A C 1 ATOM 2903 O O . TRP A 1 407 ? 22.269 -47.103 32.994 1.00 14.89 ? 391 TRP A O 1 ATOM 2904 C CB . TRP A 1 407 ? 20.774 -44.831 34.574 1.00 15.18 ? 391 TRP A CB 1 ATOM 2905 C CG . TRP A 1 407 ? 20.882 -43.555 33.791 1.00 15.80 ? 391 TRP A CG 1 ATOM 2906 C CD1 . TRP A 1 407 ? 22.023 -42.912 33.417 1.00 14.81 ? 391 TRP A CD1 1 ATOM 2907 C CD2 . TRP A 1 407 ? 19.802 -42.787 33.268 1.00 15.42 ? 391 TRP A CD2 1 ATOM 2908 N NE1 . TRP A 1 407 ? 21.719 -41.792 32.696 1.00 12.32 ? 391 TRP A NE1 1 ATOM 2909 C CE2 . TRP A 1 407 ? 20.363 -41.689 32.594 1.00 13.91 ? 391 TRP A CE2 1 ATOM 2910 C CE3 . TRP A 1 407 ? 18.415 -42.916 33.306 1.00 20.91 ? 391 TRP A CE3 1 ATOM 2911 C CZ2 . TRP A 1 407 ? 19.578 -40.728 31.963 1.00 20.36 ? 391 TRP A CZ2 1 ATOM 2912 C CZ3 . TRP A 1 407 ? 17.641 -41.955 32.680 1.00 18.91 ? 391 TRP A CZ3 1 ATOM 2913 C CH2 . TRP A 1 407 ? 18.224 -40.882 32.014 1.00 19.39 ? 391 TRP A CH2 1 ATOM 2914 N N . PHE A 1 408 ? 21.150 -45.914 31.486 1.00 13.86 ? 392 PHE A N 1 ATOM 2915 C CA . PHE A 1 408 ? 22.212 -45.969 30.504 1.00 14.24 ? 392 PHE A CA 1 ATOM 2916 C C . PHE A 1 408 ? 22.649 -44.562 30.081 1.00 14.32 ? 392 PHE A C 1 ATOM 2917 O O . PHE A 1 408 ? 21.818 -43.739 29.693 1.00 11.01 ? 392 PHE A O 1 ATOM 2918 C CB . PHE A 1 408 ? 21.798 -46.768 29.273 1.00 14.69 ? 392 PHE A CB 1 ATOM 2919 C CG . PHE A 1 408 ? 22.939 -47.018 28.335 1.00 13.68 ? 392 PHE A CG 1 ATOM 2920 C CD1 . PHE A 1 408 ? 23.949 -47.882 28.687 1.00 11.70 ? 392 PHE A CD1 1 ATOM 2921 C CD2 . PHE A 1 408 ? 23.028 -46.357 27.142 1.00 14.38 ? 392 PHE A CD2 1 ATOM 2922 C CE1 . PHE A 1 408 ? 25.004 -48.091 27.870 1.00 14.28 ? 392 PHE A CE1 1 ATOM 2923 C CE2 . PHE A 1 408 ? 24.097 -46.578 26.315 1.00 19.64 ? 392 PHE A CE2 1 ATOM 2924 C CZ . PHE A 1 408 ? 25.082 -47.443 26.683 1.00 14.55 ? 392 PHE A CZ 1 ATOM 2925 N N . LYS A 1 409 ? 23.962 -44.321 30.170 1.00 12.16 ? 393 LYS A N 1 ATOM 2926 C CA . LYS A 1 409 ? 24.592 -43.050 29.839 1.00 10.75 ? 393 LYS A CA 1 ATOM 2927 C C . LYS A 1 409 ? 25.550 -43.206 28.656 1.00 12.70 ? 393 LYS A C 1 ATOM 2928 O O . LYS A 1 409 ? 26.534 -43.938 28.732 1.00 10.36 ? 393 LYS A O 1 ATOM 2929 C CB . LYS A 1 409 ? 25.353 -42.535 31.055 1.00 11.41 ? 393 LYS A CB 1 ATOM 2930 C CG . LYS A 1 409 ? 26.214 -41.298 30.826 1.00 12.63 ? 393 LYS A CG 1 ATOM 2931 C CD . LYS A 1 409 ? 26.678 -40.785 32.182 1.00 13.78 ? 393 LYS A CD 1 ATOM 2932 C CE . LYS A 1 409 ? 27.331 -39.438 32.134 1.00 12.25 ? 393 LYS A CE 1 ATOM 2933 N NZ . LYS A 1 409 ? 27.671 -39.032 33.511 1.00 10.01 ? 393 LYS A NZ 1 ATOM 2934 N N . LYS A 1 410 ? 25.248 -42.495 27.569 1.00 14.84 ? 394 LYS A N 1 ATOM 2935 C CA . LYS A 1 410 ? 26.005 -42.586 26.314 1.00 17.20 ? 394 LYS A CA 1 ATOM 2936 C C . LYS A 1 410 ? 27.247 -41.693 26.369 1.00 13.84 ? 394 LYS A C 1 ATOM 2937 O O . LYS A 1 410 ? 27.222 -40.660 27.035 1.00 16.40 ? 394 LYS A O 1 ATOM 2938 C CB . LYS A 1 410 ? 25.099 -42.212 25.124 1.00 16.62 ? 394 LYS A CB 1 ATOM 2939 C CG . LYS A 1 410 ? 24.198 -40.998 25.372 1.00 24.91 ? 394 LYS A CG 1 ATOM 2940 C CD . LYS A 1 410 ? 23.342 -40.564 24.170 1.00 42.16 ? 394 LYS A CD 1 ATOM 2941 C CE . LYS A 1 410 ? 22.793 -39.130 24.394 1.00 58.99 ? 394 LYS A CE 1 ATOM 2942 N NZ . LYS A 1 410 ? 21.691 -38.703 23.471 1.00 57.82 ? 394 LYS A NZ 1 ATOM 2943 N N . GLY A 1 411 ? 28.326 -42.103 25.700 1.00 13.16 ? 395 GLY A N 1 ATOM 2944 C CA . GLY A 1 411 ? 29.541 -41.305 25.633 1.00 13.26 ? 395 GLY A CA 1 ATOM 2945 C C . GLY A 1 411 ? 29.236 -39.901 25.136 1.00 12.89 ? 395 GLY A C 1 ATOM 2946 O O . GLY A 1 411 ? 28.156 -39.681 24.600 1.00 13.99 ? 395 GLY A O 1 ATOM 2947 N N . SER A 1 412 ? 30.166 -38.954 25.305 1.00 10.30 ? 396 SER A N 1 ATOM 2948 C CA . SER A 1 412 ? 29.909 -37.533 24.989 1.00 8.44 ? 396 SER A CA 1 ATOM 2949 C C . SER A 1 412 ? 29.920 -37.258 23.491 1.00 7.79 ? 396 SER A C 1 ATOM 2950 O O . SER A 1 412 ? 30.549 -37.977 22.751 1.00 9.02 ? 396 SER A O 1 ATOM 2951 C CB . SER A 1 412 ? 30.921 -36.591 25.658 1.00 9.26 ? 396 SER A CB 1 ATOM 2952 O OG . SER A 1 412 ? 31.027 -36.796 27.063 1.00 11.68 ? 396 SER A OG 1 ATOM 2953 N N . SER A 1 413 ? 29.227 -36.200 23.083 1.00 6.53 ? 397 SER A N 1 ATOM 2954 C CA . SER A 1 413 ? 29.079 -35.817 21.692 1.00 8.77 ? 397 SER A CA 1 ATOM 2955 C C . SER A 1 413 ? 28.952 -34.312 21.606 1.00 8.56 ? 397 SER A C 1 ATOM 2956 O O . SER A 1 413 ? 28.391 -33.691 22.495 1.00 10.46 ? 397 SER A O 1 ATOM 2957 C CB . SER A 1 413 ? 27.824 -36.456 21.111 1.00 10.07 ? 397 SER A CB 1 ATOM 2958 O OG . SER A 1 413 ? 27.566 -35.980 19.813 1.00 11.57 ? 397 SER A OG 1 ATOM 2959 N N . ILE A 1 414 ? 29.457 -33.733 20.521 1.00 10.14 ? 398 ILE A N 1 ATOM 2960 C CA . ILE A 1 414 ? 29.404 -32.292 20.317 1.00 10.30 ? 398 ILE A CA 1 ATOM 2961 C C . ILE A 1 414 ? 28.140 -31.863 19.626 1.00 10.33 ? 398 ILE A C 1 ATOM 2962 O O . ILE A 1 414 ? 27.921 -30.670 19.444 1.00 11.76 ? 398 ILE A O 1 ATOM 2963 C CB . ILE A 1 414 ? 30.588 -31.777 19.495 1.00 6.72 ? 398 ILE A CB 1 ATOM 2964 C CG1 . ILE A 1 414 ? 30.523 -32.282 18.063 1.00 8.29 ? 398 ILE A CG1 1 ATOM 2965 C CG2 . ILE A 1 414 ? 31.882 -32.181 20.166 1.00 11.46 ? 398 ILE A CG2 1 ATOM 2966 C CD1 . ILE A 1 414 ? 31.565 -31.650 17.182 1.00 8.24 ? 398 ILE A CD1 1 ATOM 2967 N N . GLY A 1 415 ? 27.307 -32.831 19.248 1.00 9.82 ? 399 GLY A N 1 ATOM 2968 C CA . GLY A 1 415 ? 26.043 -32.544 18.594 1.00 8.99 ? 399 GLY A CA 1 ATOM 2969 C C . GLY A 1 415 ? 25.816 -33.384 17.350 1.00 9.23 ? 399 GLY A C 1 ATOM 2970 O O . GLY A 1 415 ? 26.575 -34.284 17.032 1.00 8.43 ? 399 GLY A O 1 ATOM 2971 N N . LYS A 1 416 ? 24.747 -33.065 16.644 1.00 10.60 ? 400 LYS A N 1 ATOM 2972 C CA . LYS A 1 416 ? 24.374 -33.790 15.450 1.00 12.43 ? 400 LYS A CA 1 ATOM 2973 C C . LYS A 1 416 ? 24.796 -33.021 14.230 1.00 12.32 ? 400 LYS A C 1 ATOM 2974 O O . LYS A 1 416 ? 24.839 -31.801 14.245 1.00 13.38 ? 400 LYS A O 1 ATOM 2975 C CB . LYS A 1 416 ? 22.870 -34.000 15.457 1.00 11.86 ? 400 LYS A CB 1 ATOM 2976 C CG . LYS A 1 416 ? 22.430 -34.746 16.686 1.00 14.81 ? 400 LYS A CG 1 ATOM 2977 C CD . LYS A 1 416 ? 20.949 -34.752 16.831 1.00 17.36 ? 400 LYS A CD 1 ATOM 2978 C CE . LYS A 1 416 ? 20.576 -35.470 18.094 1.00 18.65 ? 400 LYS A CE 1 ATOM 2979 N NZ . LYS A 1 416 ? 19.118 -35.443 18.250 1.00 28.09 ? 400 LYS A NZ 1 ATOM 2980 N N . MET A 1 417 ? 25.095 -33.745 13.166 1.00 11.68 ? 401 MET A N 1 ATOM 2981 C CA . MET A 1 417 ? 25.584 -33.134 11.933 1.00 17.57 ? 401 MET A CA 1 ATOM 2982 C C . MET A 1 417 ? 24.508 -32.332 11.190 1.00 16.82 ? 401 MET A C 1 ATOM 2983 O O . MET A 1 417 ? 23.452 -32.852 10.878 1.00 15.75 ? 401 MET A O 1 ATOM 2984 C CB . MET A 1 417 ? 26.116 -34.225 10.995 1.00 16.91 ? 401 MET A CB 1 ATOM 2985 C CG . MET A 1 417 ? 26.963 -33.699 9.870 1.00 18.16 ? 401 MET A CG 1 ATOM 2986 S SD . MET A 1 417 ? 28.577 -33.166 10.445 1.00 23.29 ? 401 MET A SD 1 ATOM 2987 C CE . MET A 1 417 ? 29.437 -34.756 10.455 1.00 19.23 ? 401 MET A CE 1 ATOM 2988 N N . PHE A 1 418 ? 24.793 -31.070 10.896 1.00 14.69 ? 402 PHE A N 1 ATOM 2989 C CA . PHE A 1 418 ? 23.936 -30.300 10.023 1.00 15.30 ? 402 PHE A CA 1 ATOM 2990 C C . PHE A 1 418 ? 24.105 -30.831 8.605 1.00 20.10 ? 402 PHE A C 1 ATOM 2991 O O . PHE A 1 418 ? 25.214 -30.943 8.106 1.00 20.32 ? 402 PHE A O 1 ATOM 2992 C CB . PHE A 1 418 ? 24.292 -28.821 10.117 1.00 18.05 ? 402 PHE A CB 1 ATOM 2993 C CG . PHE A 1 418 ? 23.677 -27.987 9.048 1.00 15.71 ? 402 PHE A CG 1 ATOM 2994 C CD1 . PHE A 1 418 ? 24.261 -27.905 7.810 1.00 16.50 ? 402 PHE A CD1 1 ATOM 2995 C CD2 . PHE A 1 418 ? 22.511 -27.284 9.277 1.00 15.63 ? 402 PHE A CD2 1 ATOM 2996 C CE1 . PHE A 1 418 ? 23.697 -27.141 6.814 1.00 15.31 ? 402 PHE A CE1 1 ATOM 2997 C CE2 . PHE A 1 418 ? 21.947 -26.504 8.291 1.00 14.17 ? 402 PHE A CE2 1 ATOM 2998 C CZ . PHE A 1 418 ? 22.540 -26.432 7.062 1.00 13.17 ? 402 PHE A CZ 1 ATOM 2999 N N . GLU A 1 419 ? 22.998 -31.178 7.960 1.00 26.69 ? 403 GLU A N 1 ATOM 3000 C CA . GLU A 1 419 ? 23.039 -31.762 6.616 1.00 30.18 ? 403 GLU A CA 1 ATOM 3001 C C . GLU A 1 419 ? 22.460 -30.787 5.600 1.00 25.00 ? 403 GLU A C 1 ATOM 3002 O O . GLU A 1 419 ? 21.289 -30.423 5.684 1.00 29.87 ? 403 GLU A O 1 ATOM 3003 C CB . GLU A 1 419 ? 22.259 -33.088 6.573 1.00 30.04 ? 403 GLU A CB 1 ATOM 3004 C CG . GLU A 1 419 ? 22.577 -34.098 7.711 1.00 31.74 ? 403 GLU A CG 1 ATOM 3005 C CD . GLU A 1 419 ? 23.657 -35.131 7.372 1.00 42.79 ? 403 GLU A CD 1 ATOM 3006 O OE1 . GLU A 1 419 ? 24.675 -34.765 6.742 1.00 46.75 ? 403 GLU A OE1 1 ATOM 3007 O OE2 . GLU A 1 419 ? 23.481 -36.319 7.748 1.00 48.60 ? 403 GLU A OE2 1 ATOM 3008 N N . ARG B 1 18 ? 11.600 -19.488 -54.902 1.00 28.03 ? 2 ARG B N 1 ATOM 3009 C CA . ARG B 1 18 ? 11.380 -19.706 -53.480 1.00 23.15 ? 2 ARG B CA 1 ATOM 3010 C C . ARG B 1 18 ? 10.768 -21.081 -53.178 1.00 20.32 ? 2 ARG B C 1 ATOM 3011 O O . ARG B 1 18 ? 10.932 -21.619 -52.080 1.00 18.73 ? 2 ARG B O 1 ATOM 3012 C CB . ARG B 1 18 ? 10.485 -18.612 -52.891 1.00 27.74 ? 2 ARG B CB 1 ATOM 3013 C CG . ARG B 1 18 ? 8.991 -18.792 -53.131 1.00 30.15 ? 2 ARG B CG 1 ATOM 3014 C CD . ARG B 1 18 ? 8.187 -18.320 -51.927 1.00 36.85 ? 2 ARG B CD 1 ATOM 3015 N NE . ARG B 1 18 ? 6.751 -18.486 -52.136 1.00 38.79 ? 2 ARG B NE 1 ATOM 3016 C CZ . ARG B 1 18 ? 5.809 -18.164 -51.250 1.00 46.80 ? 2 ARG B CZ 1 ATOM 3017 N NH1 . ARG B 1 18 ? 6.127 -17.655 -50.062 1.00 52.51 ? 2 ARG B NH1 1 ATOM 3018 N NH2 . ARG B 1 18 ? 4.533 -18.358 -51.559 1.00 49.42 ? 2 ARG B NH2 1 ATOM 3019 N N . CYS B 1 19 ? 10.052 -21.637 -54.147 1.00 24.43 ? 3 CYS B N 1 ATOM 3020 C CA . CYS B 1 19 ? 9.414 -22.935 -53.967 1.00 17.16 ? 3 CYS B CA 1 ATOM 3021 C C . CYS B 1 19 ? 10.250 -24.048 -54.551 1.00 14.30 ? 3 CYS B C 1 ATOM 3022 O O . CYS B 1 19 ? 10.985 -23.841 -55.505 1.00 20.06 ? 3 CYS B O 1 ATOM 3023 C CB . CYS B 1 19 ? 8.020 -22.943 -54.582 1.00 15.31 ? 3 CYS B CB 1 ATOM 3024 S SG . CYS B 1 19 ? 6.816 -22.158 -53.540 1.00 20.82 ? 3 CYS B SG 1 ATOM 3025 N N . VAL B 1 20 ? 10.148 -25.226 -53.946 1.00 15.42 ? 4 VAL B N 1 ATOM 3026 C CA . VAL B 1 20 ? 10.836 -26.409 -54.422 1.00 10.22 ? 4 VAL B CA 1 ATOM 3027 C C . VAL B 1 20 ? 9.933 -27.119 -55.412 1.00 11.75 ? 4 VAL B C 1 ATOM 3028 O O . VAL B 1 20 ? 8.847 -27.530 -55.057 1.00 12.90 ? 4 VAL B O 1 ATOM 3029 C CB . VAL B 1 20 ? 11.155 -27.391 -53.263 1.00 12.79 ? 4 VAL B CB 1 ATOM 3030 C CG1 . VAL B 1 20 ? 11.843 -28.632 -53.785 1.00 13.01 ? 4 VAL B CG1 1 ATOM 3031 C CG2 . VAL B 1 20 ? 12.000 -26.738 -52.218 1.00 16.66 ? 4 VAL B CG2 1 ATOM 3032 N N . GLY B 1 21 ? 10.377 -27.263 -56.654 1.00 11.48 ? 5 GLY B N 1 ATOM 3033 C CA . GLY B 1 21 ? 9.649 -28.036 -57.637 1.00 9.69 ? 5 GLY B CA 1 ATOM 3034 C C . GLY B 1 21 ? 9.625 -29.526 -57.350 1.00 10.09 ? 5 GLY B C 1 ATOM 3035 O O . GLY B 1 21 ? 10.606 -30.115 -56.915 1.00 10.04 ? 5 GLY B O 1 ATOM 3036 N N . ILE B 1 22 ? 8.485 -30.142 -57.629 1.00 11.05 ? 6 ILE B N 1 ATOM 3037 C CA . ILE B 1 22 ? 8.323 -31.590 -57.513 1.00 13.65 ? 6 ILE B CA 1 ATOM 3038 C C . ILE B 1 22 ? 9.072 -32.331 -58.615 1.00 11.67 ? 6 ILE B C 1 ATOM 3039 O O . ILE B 1 22 ? 9.057 -31.919 -59.765 1.00 13.29 ? 6 ILE B O 1 ATOM 3040 C CB . ILE B 1 22 ? 6.847 -31.990 -57.603 1.00 11.37 ? 6 ILE B CB 1 ATOM 3041 C CG1 . ILE B 1 22 ? 6.020 -31.198 -56.595 1.00 14.11 ? 6 ILE B CG1 1 ATOM 3042 C CG2 . ILE B 1 22 ? 6.686 -33.496 -57.380 1.00 14.26 ? 6 ILE B CG2 1 ATOM 3043 C CD1 . ILE B 1 22 ? 4.532 -31.390 -56.744 1.00 18.76 ? 6 ILE B CD1 1 ATOM 3044 N N . GLY B 1 23 ? 9.716 -33.435 -58.262 1.00 13.24 ? 7 GLY B N 1 ATOM 3045 C CA . GLY B 1 23 ? 10.463 -34.210 -59.233 1.00 12.96 ? 7 GLY B CA 1 ATOM 3046 C C . GLY B 1 23 ? 9.611 -35.281 -59.857 1.00 10.76 ? 7 GLY B C 1 ATOM 3047 O O . GLY B 1 23 ? 8.531 -35.588 -59.379 1.00 8.30 ? 7 GLY B O 1 ATOM 3048 N N . ASN B 1 24 ? 10.100 -35.843 -60.949 1.00 11.91 ? 8 ASN B N 1 ATOM 3049 C CA . ASN B 1 24 ? 9.378 -36.875 -61.674 1.00 10.79 ? 8 ASN B CA 1 ATOM 3050 C C . ASN B 1 24 ? 9.043 -38.110 -60.850 1.00 8.96 ? 8 ASN B C 1 ATOM 3051 O O . ASN B 1 24 ? 8.021 -38.731 -61.078 1.00 9.25 ? 8 ASN B O 1 ATOM 3052 C CB . ASN B 1 24 ? 10.178 -37.304 -62.890 1.00 16.86 ? 8 ASN B CB 1 ATOM 3053 C CG . ASN B 1 24 ? 10.056 -36.334 -64.021 1.00 19.00 ? 8 ASN B CG 1 ATOM 3054 O OD1 . ASN B 1 24 ? 8.955 -35.914 -64.378 1.00 23.19 ? 8 ASN B OD1 1 ATOM 3055 N ND2 . ASN B 1 24 ? 11.191 -35.963 -64.600 1.00 28.23 ? 8 ASN B ND2 1 ATOM 3056 N N . ARG B 1 25 ? 9.894 -38.461 -59.898 1.00 7.59 ? 9 ARG B N 1 ATOM 3057 C CA . ARG B 1 25 ? 9.686 -39.662 -59.104 1.00 7.19 ? 9 ARG B CA 1 ATOM 3058 C C . ARG B 1 25 ? 8.560 -39.462 -58.081 1.00 8.17 ? 9 ARG B C 1 ATOM 3059 O O . ARG B 1 25 ? 8.075 -40.421 -57.488 1.00 7.88 ? 9 ARG B O 1 ATOM 3060 C CB . ARG B 1 25 ? 10.987 -40.080 -58.411 1.00 11.33 ? 9 ARG B CB 1 ATOM 3061 C CG . ARG B 1 25 ? 11.992 -40.718 -59.375 1.00 15.12 ? 9 ARG B CG 1 ATOM 3062 C CD . ARG B 1 25 ? 13.240 -41.217 -58.682 1.00 14.93 ? 9 ARG B CD 1 ATOM 3063 N NE . ARG B 1 25 ? 13.998 -40.113 -58.116 1.00 14.94 ? 9 ARG B NE 1 ATOM 3064 C CZ . ARG B 1 25 ? 14.532 -40.098 -56.906 1.00 13.82 ? 9 ARG B CZ 1 ATOM 3065 N NH1 . ARG B 1 25 ? 14.425 -41.142 -56.100 1.00 20.03 ? 9 ARG B NH1 1 ATOM 3066 N NH2 . ARG B 1 25 ? 15.193 -39.032 -56.495 1.00 16.25 ? 9 ARG B NH2 1 ATOM 3067 N N . ASP B 1 26 ? 8.122 -38.219 -57.918 1.00 7.47 ? 10 ASP B N 1 ATOM 3068 C CA . ASP B 1 26 ? 7.123 -37.880 -56.926 1.00 7.26 ? 10 ASP B CA 1 ATOM 3069 C C . ASP B 1 26 ? 5.695 -37.769 -57.459 1.00 6.08 ? 10 ASP B C 1 ATOM 3070 O O . ASP B 1 26 ? 4.810 -37.314 -56.755 1.00 5.78 ? 10 ASP B O 1 ATOM 3071 C CB . ASP B 1 26 ? 7.542 -36.585 -56.243 1.00 9.01 ? 10 ASP B CB 1 ATOM 3072 C CG . ASP B 1 26 ? 8.430 -36.854 -55.069 1.00 12.58 ? 10 ASP B CG 1 ATOM 3073 O OD1 . ASP B 1 26 ? 8.063 -37.733 -54.282 1.00 18.66 ? 10 ASP B OD1 1 ATOM 3074 O OD2 . ASP B 1 26 ? 9.508 -36.259 -54.923 1.00 16.64 ? 10 ASP B OD2 1 ATOM 3075 N N . PHE B 1 27 ? 5.472 -38.172 -58.705 1.00 6.87 ? 11 PHE B N 1 ATOM 3076 C CA . PHE B 1 27 ? 4.123 -38.216 -59.226 1.00 6.20 ? 11 PHE B CA 1 ATOM 3077 C C . PHE B 1 27 ? 3.925 -39.355 -60.197 1.00 6.20 ? 11 PHE B C 1 ATOM 3078 O O . PHE B 1 27 ? 4.874 -39.899 -60.726 1.00 6.61 ? 11 PHE B O 1 ATOM 3079 C CB . PHE B 1 27 ? 3.694 -36.872 -59.820 1.00 6.09 ? 11 PHE B CB 1 ATOM 3080 C CG . PHE B 1 27 ? 4.392 -36.497 -61.083 1.00 8.03 ? 11 PHE B CG 1 ATOM 3081 C CD1 . PHE B 1 27 ? 5.549 -35.755 -61.047 1.00 10.41 ? 11 PHE B CD1 1 ATOM 3082 C CD2 . PHE B 1 27 ? 3.867 -36.852 -62.307 1.00 9.22 ? 11 PHE B CD2 1 ATOM 3083 C CE1 . PHE B 1 27 ? 6.177 -35.385 -62.204 1.00 10.10 ? 11 PHE B CE1 1 ATOM 3084 C CE2 . PHE B 1 27 ? 4.505 -36.482 -63.478 1.00 12.85 ? 11 PHE B CE2 1 ATOM 3085 C CZ . PHE B 1 27 ? 5.659 -35.757 -63.418 1.00 11.93 ? 11 PHE B CZ 1 ATOM 3086 N N . VAL B 1 28 ? 2.669 -39.753 -60.350 1.00 5.70 ? 12 VAL B N 1 ATOM 3087 C CA . VAL B 1 28 ? 2.285 -40.737 -61.334 1.00 7.15 ? 12 VAL B CA 1 ATOM 3088 C C . VAL B 1 28 ? 1.052 -40.244 -62.095 1.00 8.87 ? 12 VAL B C 1 ATOM 3089 O O . VAL B 1 28 ? 0.035 -39.947 -61.465 1.00 7.33 ? 12 VAL B O 1 ATOM 3090 C CB . VAL B 1 28 ? 1.974 -42.081 -60.659 1.00 7.58 ? 12 VAL B CB 1 ATOM 3091 C CG1 . VAL B 1 28 ? 1.005 -42.852 -61.474 1.00 10.94 ? 12 VAL B CG1 1 ATOM 3092 C CG2 . VAL B 1 28 ? 3.243 -42.896 -60.445 1.00 6.25 ? 12 VAL B CG2 1 ATOM 3093 N N . GLU B 1 29 ? 1.142 -40.139 -63.434 1.00 9.78 ? 13 GLU B N 1 ATOM 3094 C CA . GLU B 1 29 ? -0.045 -39.899 -64.269 1.00 9.81 ? 13 GLU B CA 1 ATOM 3095 C C . GLU B 1 29 ? -0.568 -41.236 -64.811 1.00 8.41 ? 13 GLU B C 1 ATOM 3096 O O . GLU B 1 29 ? 0.140 -41.934 -65.508 1.00 10.59 ? 13 GLU B O 1 ATOM 3097 C CB . GLU B 1 29 ? 0.229 -38.940 -65.454 1.00 9.44 ? 13 GLU B CB 1 ATOM 3098 C CG . GLU B 1 29 ? -1.045 -38.673 -66.320 1.00 8.41 ? 13 GLU B CG 1 ATOM 3099 C CD . GLU B 1 29 ? -0.773 -38.078 -67.698 1.00 10.40 ? 13 GLU B CD 1 ATOM 3100 O OE1 . GLU B 1 29 ? -1.715 -37.917 -68.502 1.00 10.40 ? 13 GLU B OE1 1 ATOM 3101 O OE2 . GLU B 1 29 ? 0.383 -37.780 -67.995 1.00 10.46 ? 13 GLU B OE2 1 ATOM 3102 N N . GLY B 1 30 ? -1.805 -41.592 -64.490 1.00 7.31 ? 14 GLY B N 1 ATOM 3103 C CA . GLY B 1 30 ? -2.350 -42.838 -64.956 1.00 9.34 ? 14 GLY B CA 1 ATOM 3104 C C . GLY B 1 30 ? -2.646 -42.756 -66.441 1.00 9.79 ? 14 GLY B C 1 ATOM 3105 O O . GLY B 1 30 ? -2.945 -41.704 -66.964 1.00 11.57 ? 14 GLY B O 1 ATOM 3106 N N . LEU B 1 31 ? -2.519 -43.866 -67.137 1.00 11.32 ? 15 LEU B N 1 ATOM 3107 C CA A LEU B 1 31 ? -2.974 -43.958 -68.513 0.37 11.69 ? 15 LEU B CA 1 ATOM 3108 C CA B LEU B 1 31 ? -2.965 -43.934 -68.512 0.63 11.16 ? 15 LEU B CA 1 ATOM 3109 C C . LEU B 1 31 ? -4.479 -43.675 -68.532 1.00 13.01 ? 15 LEU B C 1 ATOM 3110 O O . LEU B 1 31 ? -5.018 -43.134 -69.510 1.00 11.21 ? 15 LEU B O 1 ATOM 3111 C CB A LEU B 1 31 ? -2.657 -45.350 -69.066 0.37 10.62 ? 15 LEU B CB 1 ATOM 3112 C CB B LEU B 1 31 ? -2.619 -45.298 -69.106 0.63 12.02 ? 15 LEU B CB 1 ATOM 3113 C CG A LEU B 1 31 ? -3.070 -45.711 -70.491 0.37 12.98 ? 15 LEU B CG 1 ATOM 3114 C CG B LEU B 1 31 ? -3.156 -45.592 -70.500 0.63 12.98 ? 15 LEU B CG 1 ATOM 3115 C CD1 A LEU B 1 31 ? -2.301 -46.944 -70.928 0.37 13.97 ? 15 LEU B CD1 1 ATOM 3116 C CD1 B LEU B 1 31 ? -2.449 -44.735 -71.539 0.63 11.93 ? 15 LEU B CD1 1 ATOM 3117 C CD2 A LEU B 1 31 ? -4.563 -45.972 -70.605 0.37 12.48 ? 15 LEU B CD2 1 ATOM 3118 C CD2 B LEU B 1 31 ? -2.995 -47.069 -70.798 0.63 13.59 ? 15 LEU B CD2 1 ATOM 3119 N N . SER B 1 32 ? -5.150 -44.068 -67.450 1.00 9.22 ? 16 SER B N 1 ATOM 3120 C CA . SER B 1 32 ? -6.530 -43.704 -67.189 1.00 7.92 ? 16 SER B CA 1 ATOM 3121 C C . SER B 1 32 ? -6.625 -43.446 -65.690 1.00 11.85 ? 16 SER B C 1 ATOM 3122 O O . SER B 1 32 ? -5.852 -43.989 -64.908 1.00 10.75 ? 16 SER B O 1 ATOM 3123 C CB . SER B 1 32 ? -7.520 -44.772 -67.667 1.00 7.93 ? 16 SER B CB 1 ATOM 3124 O OG . SER B 1 32 ? -7.828 -45.749 -66.700 1.00 11.26 ? 16 SER B OG 1 ATOM 3125 N N . GLY B 1 33 ? -7.546 -42.581 -65.288 1.00 11.60 ? 17 GLY B N 1 ATOM 3126 C CA . GLY B 1 33 ? -7.702 -42.263 -63.889 1.00 9.49 ? 17 GLY B CA 1 ATOM 3127 C C . GLY B 1 33 ? -7.120 -40.915 -63.533 1.00 8.36 ? 17 GLY B C 1 ATOM 3128 O O . GLY B 1 33 ? -7.408 -39.911 -64.169 1.00 9.67 ? 17 GLY B O 1 ATOM 3129 N N . ALA B 1 34 ? -6.281 -40.890 -62.513 1.00 6.52 ? 18 ALA B N 1 ATOM 3130 C CA . ALA B 1 34 ? -5.830 -39.637 -61.929 1.00 6.32 ? 18 ALA B CA 1 ATOM 3131 C C . ALA B 1 34 ? -4.375 -39.312 -62.235 1.00 5.50 ? 18 ALA B C 1 ATOM 3132 O O . ALA B 1 34 ? -3.663 -40.115 -62.817 1.00 6.64 ? 18 ALA B O 1 ATOM 3133 C CB . ALA B 1 34 ? -6.021 -39.704 -60.419 1.00 5.76 ? 18 ALA B CB 1 ATOM 3134 N N . THR B 1 35 ? -3.950 -38.111 -61.847 1.00 8.63 ? 19 THR B N 1 ATOM 3135 C CA . THR B 1 35 ? -2.558 -37.891 -61.469 1.00 7.13 ? 19 THR B CA 1 ATOM 3136 C C . THR B 1 35 ? -2.530 -37.822 -59.940 1.00 5.60 ? 19 THR B C 1 ATOM 3137 O O . THR B 1 35 ? -3.318 -37.110 -59.332 1.00 6.56 ? 19 THR B O 1 ATOM 3138 C CB . THR B 1 35 ? -1.905 -36.621 -62.104 1.00 9.03 ? 19 THR B CB 1 ATOM 3139 O OG1 . THR B 1 35 ? -1.770 -36.781 -63.505 1.00 9.13 ? 19 THR B OG1 1 ATOM 3140 C CG2 . THR B 1 35 ? -0.494 -36.407 -61.574 1.00 8.49 ? 19 THR B CG2 1 ATOM 3141 N N . TRP B 1 36 ? -1.643 -38.630 -59.354 1.00 5.49 ? 20 TRP B N 1 ATOM 3142 C CA . TRP B 1 36 ? -1.382 -38.681 -57.931 1.00 5.50 ? 20 TRP B CA 1 ATOM 3143 C C . TRP B 1 36 ? 0.021 -38.146 -57.710 1.00 5.83 ? 20 TRP B C 1 ATOM 3144 O O . TRP B 1 36 ? 0.927 -38.459 -58.462 1.00 3.94 ? 20 TRP B O 1 ATOM 3145 C CB . TRP B 1 36 ? -1.481 -40.127 -57.436 1.00 5.04 ? 20 TRP B CB 1 ATOM 3146 C CG . TRP B 1 36 ? -2.885 -40.670 -57.315 1.00 5.04 ? 20 TRP B CG 1 ATOM 3147 C CD1 . TRP B 1 36 ? -4.047 -39.976 -57.427 1.00 5.22 ? 20 TRP B CD1 1 ATOM 3148 C CD2 . TRP B 1 36 ? -3.246 -42.020 -57.032 1.00 3.84 ? 20 TRP B CD2 1 ATOM 3149 N NE1 . TRP B 1 36 ? -5.118 -40.809 -57.228 1.00 4.59 ? 20 TRP B NE1 1 ATOM 3150 C CE2 . TRP B 1 36 ? -4.657 -42.076 -56.992 1.00 5.34 ? 20 TRP B CE2 1 ATOM 3151 C CE3 . TRP B 1 36 ? -2.534 -43.191 -56.811 1.00 3.93 ? 20 TRP B CE3 1 ATOM 3152 C CZ2 . TRP B 1 36 ? -5.353 -43.247 -56.725 1.00 4.84 ? 20 TRP B CZ2 1 ATOM 3153 C CZ3 . TRP B 1 36 ? -3.228 -44.365 -56.561 1.00 5.60 ? 20 TRP B CZ3 1 ATOM 3154 C CH2 . TRP B 1 36 ? -4.624 -44.383 -56.524 1.00 5.48 ? 20 TRP B CH2 1 ATOM 3155 N N . VAL B 1 37 ? 0.178 -37.310 -56.693 1.00 7.32 ? 21 VAL B N 1 ATOM 3156 C CA . VAL B 1 37 ? 1.444 -36.638 -56.400 1.00 6.68 ? 21 VAL B CA 1 ATOM 3157 C C . VAL B 1 37 ? 1.813 -36.774 -54.909 1.00 6.49 ? 21 VAL B C 1 ATOM 3158 O O . VAL B 1 37 ? 0.948 -36.697 -54.051 1.00 6.96 ? 21 VAL B O 1 ATOM 3159 C CB . VAL B 1 37 ? 1.362 -35.117 -56.693 1.00 6.58 ? 21 VAL B CB 1 ATOM 3160 C CG1 . VAL B 1 37 ? 2.746 -34.484 -56.634 1.00 5.54 ? 21 VAL B CG1 1 ATOM 3161 C CG2 . VAL B 1 37 ? 0.689 -34.843 -58.024 1.00 7.15 ? 21 VAL B CG2 1 ATOM 3162 N N . ASP B 1 38 ? 3.096 -36.923 -54.604 1.00 7.47 ? 22 ASP B N 1 ATOM 3163 C CA . ASP B 1 38 ? 3.573 -36.907 -53.218 1.00 8.59 ? 22 ASP B CA 1 ATOM 3164 C C . ASP B 1 38 ? 4.264 -35.577 -52.878 1.00 8.55 ? 22 ASP B C 1 ATOM 3165 O O . ASP B 1 38 ? 5.204 -35.167 -53.557 1.00 10.52 ? 22 ASP B O 1 ATOM 3166 C CB . ASP B 1 38 ? 4.548 -38.066 -52.965 1.00 10.48 ? 22 ASP B CB 1 ATOM 3167 C CG . ASP B 1 38 ? 3.864 -39.418 -52.877 1.00 12.40 ? 22 ASP B CG 1 ATOM 3168 O OD1 . ASP B 1 38 ? 2.632 -39.472 -52.747 1.00 13.48 ? 22 ASP B OD1 1 ATOM 3169 O OD2 . ASP B 1 38 ? 4.563 -40.447 -52.927 1.00 16.14 ? 22 ASP B OD2 1 ATOM 3170 N N . VAL B 1 39 ? 3.805 -34.905 -51.825 1.00 7.63 ? 23 VAL B N 1 ATOM 3171 C CA . VAL B 1 39 ? 4.509 -33.734 -51.311 1.00 11.14 ? 23 VAL B CA 1 ATOM 3172 C C . VAL B 1 39 ? 4.713 -33.815 -49.822 1.00 9.53 ? 23 VAL B C 1 ATOM 3173 O O . VAL B 1 39 ? 3.922 -34.402 -49.106 1.00 7.95 ? 23 VAL B O 1 ATOM 3174 C CB . VAL B 1 39 ? 3.791 -32.421 -51.601 1.00 11.51 ? 23 VAL B CB 1 ATOM 3175 C CG1 . VAL B 1 39 ? 3.633 -32.226 -53.103 1.00 11.22 ? 23 VAL B CG1 1 ATOM 3176 C CG2 . VAL B 1 39 ? 2.464 -32.358 -50.869 1.00 12.34 ? 23 VAL B CG2 1 ATOM 3177 N N . VAL B 1 40 ? 5.805 -33.231 -49.359 1.00 9.31 ? 24 VAL B N 1 ATOM 3178 C CA . VAL B 1 40 ? 6.020 -33.097 -47.938 1.00 8.88 ? 24 VAL B CA 1 ATOM 3179 C C . VAL B 1 40 ? 6.083 -31.623 -47.633 1.00 7.89 ? 24 VAL B C 1 ATOM 3180 O O . VAL B 1 40 ? 6.805 -30.887 -48.276 1.00 9.06 ? 24 VAL B O 1 ATOM 3181 C CB . VAL B 1 40 ? 7.298 -33.800 -47.455 1.00 9.58 ? 24 VAL B CB 1 ATOM 3182 C CG1 . VAL B 1 40 ? 7.479 -33.545 -45.979 1.00 14.00 ? 24 VAL B CG1 1 ATOM 3183 C CG2 . VAL B 1 40 ? 7.217 -35.304 -47.695 1.00 14.60 ? 24 VAL B CG2 1 ATOM 3184 N N . LEU B 1 41 ? 5.282 -31.194 -46.674 1.00 9.00 ? 25 LEU B N 1 ATOM 3185 C CA . LEU B 1 41 ? 5.222 -29.801 -46.279 1.00 10.24 ? 25 LEU B CA 1 ATOM 3186 C C . LEU B 1 41 ? 5.940 -29.606 -44.943 1.00 10.93 ? 25 LEU B C 1 ATOM 3187 O O . LEU B 1 41 ? 5.783 -30.371 -44.006 1.00 9.83 ? 25 LEU B O 1 ATOM 3188 C CB . LEU B 1 41 ? 3.770 -29.314 -46.206 1.00 9.24 ? 25 LEU B CB 1 ATOM 3189 C CG . LEU B 1 41 ? 2.866 -29.635 -47.400 1.00 9.08 ? 25 LEU B CG 1 ATOM 3190 C CD1 . LEU B 1 41 ? 1.488 -29.075 -47.137 1.00 12.01 ? 25 LEU B CD1 1 ATOM 3191 C CD2 . LEU B 1 41 ? 3.408 -29.098 -48.705 1.00 8.00 ? 25 LEU B CD2 1 ATOM 3192 N N . GLU B 1 42 ? 6.775 -28.584 -44.904 1.00 10.95 ? 26 GLU B N 1 ATOM 3193 C CA . GLU B 1 42 ? 7.529 -28.243 -43.731 1.00 16.27 ? 26 GLU B CA 1 ATOM 3194 C C . GLU B 1 42 ? 7.429 -26.743 -43.568 1.00 13.85 ? 26 GLU B C 1 ATOM 3195 O O . GLU B 1 42 ? 7.493 -26.009 -44.529 1.00 11.33 ? 26 GLU B O 1 ATOM 3196 C CB . GLU B 1 42 ? 9.000 -28.633 -43.899 1.00 17.70 ? 26 GLU B CB 1 ATOM 3197 C CG . GLU B 1 42 ? 9.209 -29.931 -44.638 1.00 21.41 ? 26 GLU B CG 1 ATOM 3198 C CD . GLU B 1 42 ? 10.009 -30.961 -43.861 1.00 24.67 ? 26 GLU B CD 1 ATOM 3199 O OE1 . GLU B 1 42 ? 9.935 -30.957 -42.615 1.00 34.51 ? 26 GLU B OE1 1 ATOM 3200 O OE2 . GLU B 1 42 ? 10.695 -31.789 -44.507 1.00 19.73 ? 26 GLU B OE2 1 ATOM 3201 N N . HIS B 1 43 ? 7.227 -26.314 -42.334 1.00 19.69 ? 27 HIS B N 1 ATOM 3202 C CA . HIS B 1 43 ? 7.311 -24.922 -41.937 1.00 20.31 ? 27 HIS B CA 1 ATOM 3203 C C . HIS B 1 43 ? 8.424 -24.160 -42.666 1.00 20.28 ? 27 HIS B C 1 ATOM 3204 O O . HIS B 1 43 ? 9.581 -24.597 -42.696 1.00 18.78 ? 27 HIS B O 1 ATOM 3205 C CB . HIS B 1 43 ? 7.563 -24.890 -40.428 1.00 28.89 ? 27 HIS B CB 1 ATOM 3206 C CG . HIS B 1 43 ? 8.692 -25.782 -39.991 1.00 28.14 ? 27 HIS B CG 1 ATOM 3207 N ND1 . HIS B 1 43 ? 10.003 -25.398 -40.037 1.00 26.60 ? 27 HIS B ND1 1 ATOM 3208 C CD2 . HIS B 1 43 ? 8.684 -27.063 -39.525 1.00 26.52 ? 27 HIS B CD2 1 ATOM 3209 C CE1 . HIS B 1 43 ? 10.777 -26.388 -39.602 1.00 31.17 ? 27 HIS B CE1 1 ATOM 3210 N NE2 . HIS B 1 43 ? 9.993 -27.399 -39.283 1.00 29.96 ? 27 HIS B NE2 1 ATOM 3211 N N . GLY B 1 44 ? 8.066 -23.016 -43.252 1.00 22.27 ? 28 GLY B N 1 ATOM 3212 C CA . GLY B 1 44 ? 9.039 -22.126 -43.872 1.00 24.94 ? 28 GLY B CA 1 ATOM 3213 C C . GLY B 1 44 ? 9.368 -22.413 -45.332 1.00 22.61 ? 28 GLY B C 1 ATOM 3214 O O . GLY B 1 44 ? 10.106 -21.668 -45.977 1.00 28.88 ? 28 GLY B O 1 ATOM 3215 N N . SER B 1 45 ? 8.820 -23.492 -45.868 1.00 19.95 ? 29 SER B N 1 ATOM 3216 C CA . SER B 1 45 ? 9.173 -23.927 -47.204 1.00 17.72 ? 29 SER B CA 1 ATOM 3217 C C . SER B 1 45 ? 7.919 -24.251 -47.975 1.00 12.89 ? 29 SER B C 1 ATOM 3218 O O . SER B 1 45 ? 6.907 -24.599 -47.399 1.00 16.26 ? 29 SER B O 1 ATOM 3219 C CB . SER B 1 45 ? 10.082 -25.150 -47.131 1.00 19.35 ? 29 SER B CB 1 ATOM 3220 O OG . SER B 1 45 ? 9.989 -25.927 -48.306 1.00 24.51 ? 29 SER B OG 1 ATOM 3221 N N . CYS B 1 46 ? 7.983 -24.128 -49.284 1.00 13.79 ? 30 CYS B N 1 ATOM 3222 C CA . CYS B 1 46 ? 6.812 -24.403 -50.091 1.00 13.24 ? 30 CYS B CA 1 ATOM 3223 C C . CYS B 1 46 ? 7.203 -25.271 -51.263 1.00 9.98 ? 30 CYS B C 1 ATOM 3224 O O . CYS B 1 46 ? 8.364 -25.396 -51.585 1.00 11.78 ? 30 CYS B O 1 ATOM 3225 C CB . CYS B 1 46 ? 6.115 -23.109 -50.524 1.00 12.47 ? 30 CYS B CB 1 ATOM 3226 S SG . CYS B 1 46 ? 7.052 -22.008 -51.524 1.00 22.04 ? 30 CYS B SG 1 ATOM 3227 N N . VAL B 1 47 ? 6.219 -25.918 -51.856 1.00 10.20 ? 31 VAL B N 1 ATOM 3228 C CA A VAL B 1 47 ? 6.436 -26.854 -52.937 0.49 12.16 ? 31 VAL B CA 1 ATOM 3229 C CA B VAL B 1 47 ? 6.483 -26.817 -52.956 0.51 11.81 ? 31 VAL B CA 1 ATOM 3230 C C . VAL B 1 47 ? 5.680 -26.352 -54.155 1.00 9.48 ? 31 VAL B C 1 ATOM 3231 O O . VAL B 1 47 ? 4.633 -25.748 -54.010 1.00 11.65 ? 31 VAL B O 1 ATOM 3232 C CB A VAL B 1 47 ? 5.918 -28.247 -52.542 0.49 11.47 ? 31 VAL B CB 1 ATOM 3233 C CB B VAL B 1 47 ? 6.170 -28.290 -52.587 0.51 11.51 ? 31 VAL B CB 1 ATOM 3234 C CG1 A VAL B 1 47 ? 6.080 -29.226 -53.684 0.49 11.92 ? 31 VAL B CG1 1 ATOM 3235 C CG1 B VAL B 1 47 ? 7.081 -28.754 -51.464 0.51 12.16 ? 31 VAL B CG1 1 ATOM 3236 C CG2 A VAL B 1 47 ? 6.638 -28.741 -51.297 0.49 12.00 ? 31 VAL B CG2 1 ATOM 3237 C CG2 B VAL B 1 47 ? 4.727 -28.458 -52.180 0.51 11.04 ? 31 VAL B CG2 1 ATOM 3238 N N . THR B 1 48 ? 6.200 -26.592 -55.342 1.00 11.48 ? 32 THR B N 1 ATOM 3239 C CA . THR B 1 48 ? 5.510 -26.130 -56.531 1.00 11.70 ? 32 THR B CA 1 ATOM 3240 C C . THR B 1 48 ? 5.538 -27.145 -57.642 1.00 11.29 ? 32 THR B C 1 ATOM 3241 O O . THR B 1 48 ? 6.377 -28.023 -57.689 1.00 10.88 ? 32 THR B O 1 ATOM 3242 C CB . THR B 1 48 ? 6.071 -24.781 -57.049 1.00 15.00 ? 32 THR B CB 1 ATOM 3243 O OG1 . THR B 1 48 ? 5.429 -24.426 -58.273 1.00 12.94 ? 32 THR B OG1 1 ATOM 3244 C CG2 . THR B 1 48 ? 7.545 -24.860 -57.313 1.00 15.32 ? 32 THR B CG2 1 ATOM 3245 N N . THR B 1 49 ? 4.560 -27.041 -58.518 1.00 13.78 ? 33 THR B N 1 ATOM 3246 C CA . THR B 1 49 ? 4.552 -27.811 -59.748 1.00 16.62 ? 33 THR B CA 1 ATOM 3247 C C . THR B 1 49 ? 3.707 -27.054 -60.741 1.00 18.02 ? 33 THR B C 1 ATOM 3248 O O . THR B 1 49 ? 3.016 -26.092 -60.391 1.00 16.64 ? 33 THR B O 1 ATOM 3249 C CB . THR B 1 49 ? 3.956 -29.218 -59.570 1.00 16.46 ? 33 THR B CB 1 ATOM 3250 O OG1 . THR B 1 49 ? 4.381 -30.066 -60.642 1.00 16.61 ? 33 THR B OG1 1 ATOM 3251 C CG2 . THR B 1 49 ? 2.422 -29.166 -59.546 1.00 20.57 ? 33 THR B CG2 1 ATOM 3252 N N . MET B 1 50 ? 3.764 -27.495 -61.988 1.00 22.39 ? 34 MET B N 1 ATOM 3253 C CA . MET B 1 50 ? 2.917 -26.949 -63.028 1.00 19.36 ? 34 MET B CA 1 ATOM 3254 C C . MET B 1 50 ? 2.620 -28.052 -64.027 1.00 16.26 ? 34 MET B C 1 ATOM 3255 O O . MET B 1 50 ? 3.453 -28.918 -64.282 1.00 13.47 ? 34 MET B O 1 ATOM 3256 C CB . MET B 1 50 ? 3.620 -25.790 -63.723 1.00 23.92 ? 34 MET B CB 1 ATOM 3257 C CG . MET B 1 50 ? 4.612 -26.220 -64.783 1.00 25.40 ? 34 MET B CG 1 ATOM 3258 S SD . MET B 1 50 ? 5.499 -24.834 -65.533 1.00 33.55 ? 34 MET B SD 1 ATOM 3259 C CE . MET B 1 50 ? 4.165 -23.749 -66.000 1.00 22.76 ? 34 MET B CE 1 ATOM 3260 N N . ALA B 1 51 ? 1.426 -28.009 -64.597 1.00 24.41 ? 35 ALA B N 1 ATOM 3261 C CA . ALA B 1 51 ? 1.019 -28.998 -65.575 1.00 25.15 ? 35 ALA B CA 1 ATOM 3262 C C . ALA B 1 51 ? 1.199 -28.374 -66.939 1.00 24.40 ? 35 ALA B C 1 ATOM 3263 O O . ALA B 1 51 ? 1.306 -27.159 -67.052 1.00 22.85 ? 35 ALA B O 1 ATOM 3264 C CB . ALA B 1 51 ? -0.419 -29.420 -65.350 1.00 21.59 ? 35 ALA B CB 1 ATOM 3265 N N . LYS B 1 52 ? 1.252 -29.229 -67.957 1.00 30.80 ? 36 LYS B N 1 ATOM 3266 C CA . LYS B 1 52 ? 1.469 -28.828 -69.344 1.00 32.20 ? 36 LYS B CA 1 ATOM 3267 C C . LYS B 1 52 ? 0.659 -27.570 -69.674 1.00 28.38 ? 36 LYS B C 1 ATOM 3268 O O . LYS B 1 52 ? -0.571 -27.598 -69.639 1.00 30.45 ? 36 LYS B O 1 ATOM 3269 C CB . LYS B 1 52 ? 1.067 -30.003 -70.266 1.00 38.04 ? 36 LYS B CB 1 ATOM 3270 C CG . LYS B 1 52 ? 1.693 -30.023 -71.672 1.00 42.17 ? 36 LYS B CG 1 ATOM 3271 C CD . LYS B 1 52 ? 1.279 -31.273 -72.464 1.00 32.00 ? 36 LYS B CD 1 ATOM 3272 C CE . LYS B 1 52 ? 1.957 -31.305 -73.828 1.00 45.10 ? 36 LYS B CE 1 ATOM 3273 N NZ . LYS B 1 52 ? 2.015 -32.656 -74.485 1.00 54.98 ? 36 LYS B NZ 1 ATOM 3274 N N . ASP B 1 53 ? 1.354 -26.478 -69.997 1.00 25.97 ? 37 ASP B N 1 ATOM 3275 C CA . ASP B 1 53 ? 0.728 -25.184 -70.337 1.00 30.08 ? 37 ASP B CA 1 ATOM 3276 C C . ASP B 1 53 ? -0.419 -24.773 -69.395 1.00 32.41 ? 37 ASP B C 1 ATOM 3277 O O . ASP B 1 53 ? -1.505 -24.407 -69.856 1.00 34.78 ? 37 ASP B O 1 ATOM 3278 C CB . ASP B 1 53 ? 0.231 -25.165 -71.800 1.00 39.53 ? 37 ASP B CB 1 ATOM 3279 C CG . ASP B 1 53 ? 1.369 -25.007 -72.823 1.00 40.78 ? 37 ASP B CG 1 ATOM 3280 O OD1 . ASP B 1 53 ? 2.190 -24.067 -72.687 1.00 43.72 ? 37 ASP B OD1 1 ATOM 3281 O OD2 . ASP B 1 53 ? 1.441 -25.831 -73.762 1.00 35.15 ? 37 ASP B OD2 1 ATOM 3282 N N . LYS B 1 54 ? -0.162 -24.830 -68.083 1.00 30.08 ? 38 LYS B N 1 ATOM 3283 C CA . LYS B 1 54 ? -1.091 -24.349 -67.052 1.00 24.45 ? 38 LYS B CA 1 ATOM 3284 C C . LYS B 1 54 ? -0.361 -23.417 -66.083 1.00 22.02 ? 38 LYS B C 1 ATOM 3285 O O . LYS B 1 54 ? 0.858 -23.343 -66.104 1.00 19.94 ? 38 LYS B O 1 ATOM 3286 C CB . LYS B 1 54 ? -1.719 -25.532 -66.288 1.00 23.40 ? 38 LYS B CB 1 ATOM 3287 C CG . LYS B 1 54 ? -2.999 -26.062 -66.938 1.00 21.99 ? 38 LYS B CG 1 ATOM 3288 C CD . LYS B 1 54 ? -3.532 -27.308 -66.272 1.00 24.18 ? 38 LYS B CD 1 ATOM 3289 C CE . LYS B 1 54 ? -4.753 -27.858 -67.013 1.00 31.05 ? 38 LYS B CE 1 ATOM 3290 N NZ . LYS B 1 54 ? -5.897 -26.902 -67.083 1.00 34.04 ? 38 LYS B NZ 1 ATOM 3291 N N . PRO B 1 55 ? -1.107 -22.700 -65.224 1.00 23.92 ? 39 PRO B N 1 ATOM 3292 C CA . PRO B 1 55 ? -0.459 -21.877 -64.200 1.00 22.53 ? 39 PRO B CA 1 ATOM 3293 C C . PRO B 1 55 ? 0.325 -22.722 -63.198 1.00 18.54 ? 39 PRO B C 1 ATOM 3294 O O . PRO B 1 55 ? 0.055 -23.903 -63.034 1.00 18.38 ? 39 PRO B O 1 ATOM 3295 C CB . PRO B 1 55 ? -1.639 -21.204 -63.490 1.00 22.01 ? 39 PRO B CB 1 ATOM 3296 C CG . PRO B 1 55 ? -2.754 -21.283 -64.428 1.00 23.04 ? 39 PRO B CG 1 ATOM 3297 C CD . PRO B 1 55 ? -2.569 -22.559 -65.182 1.00 25.49 ? 39 PRO B CD 1 ATOM 3298 N N . THR B 1 56 ? 1.291 -22.107 -62.535 1.00 18.97 ? 40 THR B N 1 ATOM 3299 C CA . THR B 1 56 ? 2.030 -22.780 -61.481 1.00 21.78 ? 40 THR B CA 1 ATOM 3300 C C . THR B 1 56 ? 1.148 -22.952 -60.244 1.00 17.34 ? 40 THR B C 1 ATOM 3301 O O . THR B 1 56 ? 0.326 -22.098 -59.937 1.00 16.83 ? 40 THR B O 1 ATOM 3302 C CB . THR B 1 56 ? 3.262 -21.975 -61.124 1.00 21.05 ? 40 THR B CB 1 ATOM 3303 O OG1 . THR B 1 56 ? 3.983 -21.682 -62.326 1.00 25.03 ? 40 THR B OG1 1 ATOM 3304 C CG2 . THR B 1 56 ? 4.153 -22.747 -60.165 1.00 19.44 ? 40 THR B CG2 1 ATOM 3305 N N . LEU B 1 57 ? 1.314 -24.074 -59.561 1.00 15.34 ? 41 LEU B N 1 ATOM 3306 C CA . LEU B 1 57 ? 0.548 -24.375 -58.376 1.00 14.83 ? 41 LEU B CA 1 ATOM 3307 C C . LEU B 1 57 ? 1.539 -24.387 -57.217 1.00 13.71 ? 41 LEU B C 1 ATOM 3308 O O . LEU B 1 57 ? 2.635 -24.911 -57.352 1.00 16.27 ? 41 LEU B O 1 ATOM 3309 C CB . LEU B 1 57 ? -0.131 -25.727 -58.570 1.00 13.81 ? 41 LEU B CB 1 ATOM 3310 C CG . LEU B 1 57 ? -1.207 -26.203 -57.614 1.00 18.00 ? 41 LEU B CG 1 ATOM 3311 C CD1 . LEU B 1 57 ? -2.228 -25.141 -57.404 1.00 18.66 ? 41 LEU B CD1 1 ATOM 3312 C CD2 . LEU B 1 57 ? -1.884 -27.404 -58.202 1.00 20.70 ? 41 LEU B CD2 1 ATOM 3313 N N . ASP B 1 58 ? 1.184 -23.751 -56.109 1.00 16.18 ? 42 ASP B N 1 ATOM 3314 C CA . ASP B 1 58 ? 2.005 -23.794 -54.910 1.00 14.50 ? 42 ASP B CA 1 ATOM 3315 C C . ASP B 1 58 ? 1.218 -24.351 -53.765 1.00 11.65 ? 42 ASP B C 1 ATOM 3316 O O . ASP B 1 58 ? 0.043 -24.076 -53.643 1.00 14.59 ? 42 ASP B O 1 ATOM 3317 C CB . ASP B 1 58 ? 2.447 -22.410 -54.515 1.00 15.25 ? 42 ASP B CB 1 ATOM 3318 C CG . ASP B 1 58 ? 3.313 -21.781 -55.535 1.00 19.99 ? 42 ASP B CG 1 ATOM 3319 O OD1 . ASP B 1 58 ? 3.654 -22.458 -56.525 1.00 23.64 ? 42 ASP B OD1 1 ATOM 3320 O OD2 . ASP B 1 58 ? 3.683 -20.614 -55.334 1.00 25.77 ? 42 ASP B OD2 1 ATOM 3321 N N . ILE B 1 59 ? 1.885 -25.125 -52.920 1.00 12.61 ? 43 ILE B N 1 ATOM 3322 C CA . ILE B 1 59 ? 1.286 -25.647 -51.696 1.00 13.03 ? 43 ILE B CA 1 ATOM 3323 C C . ILE B 1 59 ? 2.218 -25.345 -50.539 1.00 11.19 ? 43 ILE B C 1 ATOM 3324 O O . ILE B 1 59 ? 3.419 -25.575 -50.631 1.00 9.61 ? 43 ILE B O 1 ATOM 3325 C CB . ILE B 1 59 ? 1.129 -27.159 -51.711 1.00 8.59 ? 43 ILE B CB 1 ATOM 3326 C CG1 . ILE B 1 59 ? 0.790 -27.683 -53.103 1.00 14.02 ? 43 ILE B CG1 1 ATOM 3327 C CG2 . ILE B 1 59 ? 0.110 -27.573 -50.659 1.00 9.79 ? 43 ILE B CG2 1 ATOM 3328 C CD1 . ILE B 1 59 ? -0.405 -27.058 -53.757 1.00 18.94 ? 43 ILE B CD1 1 ATOM 3329 N N . GLU B 1 60 ? 1.670 -24.858 -49.435 1.00 11.90 ? 44 GLU B N 1 ATOM 3330 C CA . GLU B 1 60 ? 2.511 -24.409 -48.343 1.00 9.40 ? 44 GLU B CA 1 ATOM 3331 C C . GLU B 1 60 ? 1.845 -24.602 -46.991 1.00 9.54 ? 44 GLU B C 1 ATOM 3332 O O . GLU B 1 60 ? 0.689 -24.228 -46.822 1.00 8.53 ? 44 GLU B O 1 ATOM 3333 C CB . GLU B 1 60 ? 2.839 -22.945 -48.548 1.00 12.02 ? 44 GLU B CB 1 ATOM 3334 C CG . GLU B 1 60 ? 3.800 -22.382 -47.556 1.00 13.50 ? 44 GLU B CG 1 ATOM 3335 C CD . GLU B 1 60 ? 4.192 -20.966 -47.916 1.00 22.87 ? 44 GLU B CD 1 ATOM 3336 O OE1 . GLU B 1 60 ? 3.918 -20.554 -49.061 1.00 33.82 ? 44 GLU B OE1 1 ATOM 3337 O OE2 . GLU B 1 60 ? 4.754 -20.255 -47.068 1.00 23.96 ? 44 GLU B OE2 1 ATOM 3338 N N . LEU B 1 61 ? 2.573 -25.216 -46.048 1.00 11.52 ? 45 LEU B N 1 ATOM 3339 C CA . LEU B 1 61 ? 2.141 -25.293 -44.633 1.00 12.18 ? 45 LEU B CA 1 ATOM 3340 C C . LEU B 1 61 ? 2.397 -23.960 -43.920 1.00 9.12 ? 45 LEU B C 1 ATOM 3341 O O . LEU B 1 61 ? 3.529 -23.514 -43.777 1.00 11.02 ? 45 LEU B O 1 ATOM 3342 C CB . LEU B 1 61 ? 2.823 -26.459 -43.870 1.00 10.07 ? 45 LEU B CB 1 ATOM 3343 C CG . LEU B 1 61 ? 2.498 -26.667 -42.373 1.00 7.36 ? 45 LEU B CG 1 ATOM 3344 C CD1 . LEU B 1 61 ? 1.032 -26.927 -42.143 1.00 4.69 ? 45 LEU B CD1 1 ATOM 3345 C CD2 . LEU B 1 61 ? 3.293 -27.805 -41.810 1.00 7.81 ? 45 LEU B CD2 1 ATOM 3346 N N . LEU B 1 62 ? 1.317 -23.341 -43.482 1.00 7.68 ? 46 LEU B N 1 ATOM 3347 C CA . LEU B 1 62 ? 1.371 -22.047 -42.814 1.00 10.87 ? 46 LEU B CA 1 ATOM 3348 C C . LEU B 1 62 ? 1.506 -22.158 -41.318 1.00 10.48 ? 46 LEU B C 1 ATOM 3349 O O . LEU B 1 62 ? 2.135 -21.313 -40.684 1.00 14.93 ? 46 LEU B O 1 ATOM 3350 C CB . LEU B 1 62 ? 0.086 -21.270 -43.077 1.00 10.63 ? 46 LEU B CB 1 ATOM 3351 C CG . LEU B 1 62 ? -0.105 -20.813 -44.498 1.00 9.65 ? 46 LEU B CG 1 ATOM 3352 C CD1 . LEU B 1 62 ? -1.439 -20.136 -44.674 1.00 12.75 ? 46 LEU B CD1 1 ATOM 3353 C CD2 . LEU B 1 62 ? 1.030 -19.886 -44.853 1.00 18.31 ? 46 LEU B CD2 1 ATOM 3354 N N . LYS B 1 63 ? 0.893 -23.172 -40.725 1.00 9.49 ? 47 LYS B N 1 ATOM 3355 C CA . LYS B 1 63 ? 0.813 -23.190 -39.285 1.00 8.69 ? 47 LYS B CA 1 ATOM 3356 C C . LYS B 1 63 ? 0.334 -24.517 -38.752 1.00 7.61 ? 47 LYS B C 1 ATOM 3357 O O . LYS B 1 63 ? -0.490 -25.151 -39.373 1.00 8.69 ? 47 LYS B O 1 ATOM 3358 C CB . LYS B 1 63 ? -0.143 -22.082 -38.854 1.00 10.61 ? 47 LYS B CB 1 ATOM 3359 C CG . LYS B 1 63 ? -0.081 -21.724 -37.387 1.00 15.37 ? 47 LYS B CG 1 ATOM 3360 C CD . LYS B 1 63 ? -0.988 -20.546 -37.106 1.00 16.48 ? 47 LYS B CD 1 ATOM 3361 C CE . LYS B 1 63 ? -1.124 -20.288 -35.616 1.00 24.11 ? 47 LYS B CE 1 ATOM 3362 N NZ . LYS B 1 63 ? -2.053 -19.155 -35.299 1.00 25.72 ? 47 LYS B NZ 1 ATOM 3363 N N . THR B 1 64 ? 0.868 -24.910 -37.598 1.00 10.13 ? 48 THR B N 1 ATOM 3364 C CA . THR B 1 64 ? 0.456 -26.109 -36.866 1.00 10.39 ? 48 THR B CA 1 ATOM 3365 C C . THR B 1 64 ? 0.086 -25.670 -35.460 1.00 10.18 ? 48 THR B C 1 ATOM 3366 O O . THR B 1 64 ? 0.821 -24.937 -34.832 1.00 11.97 ? 48 THR B O 1 ATOM 3367 C CB . THR B 1 64 ? 1.576 -27.149 -36.790 1.00 9.39 ? 48 THR B CB 1 ATOM 3368 O OG1 . THR B 1 64 ? 2.028 -27.457 -38.112 1.00 10.29 ? 48 THR B OG1 1 ATOM 3369 C CG2 . THR B 1 64 ? 1.077 -28.424 -36.111 1.00 9.32 ? 48 THR B CG2 1 ATOM 3370 N N . GLU B 1 65 ? -1.050 -26.139 -34.971 1.00 11.61 ? 49 GLU B N 1 ATOM 3371 C CA . GLU B 1 65 ? -1.688 -25.563 -33.818 1.00 8.78 ? 49 GLU B CA 1 ATOM 3372 C C . GLU B 1 65 ? -2.256 -26.640 -32.951 1.00 9.70 ? 49 GLU B C 1 ATOM 3373 O O . GLU B 1 65 ? -2.926 -27.528 -33.434 1.00 9.09 ? 49 GLU B O 1 ATOM 3374 C CB . GLU B 1 65 ? -2.833 -24.700 -34.312 1.00 14.96 ? 49 GLU B CB 1 ATOM 3375 C CG . GLU B 1 65 ? -3.218 -23.557 -33.429 1.00 21.28 ? 49 GLU B CG 1 ATOM 3376 C CD . GLU B 1 65 ? -3.962 -22.487 -34.206 1.00 22.78 ? 49 GLU B CD 1 ATOM 3377 O OE1 . GLU B 1 65 ? -3.589 -22.266 -35.375 1.00 25.14 ? 49 GLU B OE1 1 ATOM 3378 O OE2 . GLU B 1 65 ? -4.919 -21.880 -33.674 1.00 29.26 ? 49 GLU B OE2 1 ATOM 3379 N N . VAL B 1 66 ? -1.987 -26.543 -31.659 1.00 10.34 ? 50 VAL B N 1 ATOM 3380 C CA . VAL B 1 66 ? -2.609 -27.401 -30.676 1.00 8.41 ? 50 VAL B CA 1 ATOM 3381 C C . VAL B 1 66 ? -3.468 -26.534 -29.798 1.00 11.07 ? 50 VAL B C 1 ATOM 3382 O O . VAL B 1 66 ? -2.982 -25.588 -29.220 1.00 11.04 ? 50 VAL B O 1 ATOM 3383 C CB . VAL B 1 66 ? -1.573 -28.113 -29.844 1.00 6.29 ? 50 VAL B CB 1 ATOM 3384 C CG1 . VAL B 1 66 ? -2.205 -28.677 -28.596 1.00 9.33 ? 50 VAL B CG1 1 ATOM 3385 C CG2 . VAL B 1 66 ? -0.906 -29.216 -30.669 1.00 8.23 ? 50 VAL B CG2 1 ATOM 3386 N N . THR B 1 67 ? -4.757 -26.846 -29.714 1.00 9.48 ? 51 THR B N 1 ATOM 3387 C CA . THR B 1 67 ? -5.705 -25.964 -29.053 1.00 13.35 ? 51 THR B CA 1 ATOM 3388 C C . THR B 1 67 ? -6.531 -26.758 -28.078 1.00 12.34 ? 51 THR B C 1 ATOM 3389 O O . THR B 1 67 ? -6.948 -27.869 -28.377 1.00 10.72 ? 51 THR B O 1 ATOM 3390 C CB . THR B 1 67 ? -6.673 -25.288 -30.042 1.00 14.22 ? 51 THR B CB 1 ATOM 3391 O OG1 . THR B 1 67 ? -6.019 -25.072 -31.294 1.00 17.49 ? 51 THR B OG1 1 ATOM 3392 C CG2 . THR B 1 67 ? -7.166 -23.950 -29.486 1.00 19.97 ? 51 THR B CG2 1 ATOM 3393 N N . ASN B 1 68 ? -6.729 -26.185 -26.900 1.00 13.37 ? 52 ASN B N 1 ATOM 3394 C CA . ASN B 1 68 ? -7.639 -26.717 -25.894 1.00 14.09 ? 52 ASN B CA 1 ATOM 3395 C C . ASN B 1 68 ? -7.427 -28.162 -25.473 1.00 10.04 ? 52 ASN B C 1 ATOM 3396 O O . ASN B 1 68 ? -8.392 -28.892 -25.368 1.00 8.83 ? 52 ASN B O 1 ATOM 3397 C CB . ASN B 1 68 ? -9.087 -26.534 -26.351 1.00 13.09 ? 52 ASN B CB 1 ATOM 3398 C CG . ASN B 1 68 ? -9.620 -25.165 -26.030 1.00 11.26 ? 52 ASN B CG 1 ATOM 3399 O OD1 . ASN B 1 68 ? -9.107 -24.501 -25.161 1.00 23.03 ? 52 ASN B OD1 1 ATOM 3400 N ND2 . ASN B 1 68 ? -10.663 -24.753 -26.705 1.00 12.51 ? 52 ASN B ND2 1 ATOM 3401 N N . PRO B 1 69 ? -6.170 -28.573 -25.217 1.00 9.09 ? 53 PRO B N 1 ATOM 3402 C CA . PRO B 1 69 ? -5.879 -29.937 -24.744 1.00 9.52 ? 53 PRO B CA 1 ATOM 3403 C C . PRO B 1 69 ? -6.382 -30.213 -23.320 1.00 7.24 ? 53 PRO B C 1 ATOM 3404 O O . PRO B 1 69 ? -6.356 -29.308 -22.492 1.00 10.53 ? 53 PRO B O 1 ATOM 3405 C CB . PRO B 1 69 ? -4.343 -30.017 -24.809 1.00 8.28 ? 53 PRO B CB 1 ATOM 3406 C CG . PRO B 1 69 ? -3.870 -28.622 -24.762 1.00 9.06 ? 53 PRO B CG 1 ATOM 3407 C CD . PRO B 1 69 ? -4.934 -27.801 -25.459 1.00 10.35 ? 53 PRO B CD 1 ATOM 3408 N N . ALA B 1 70 ? -6.843 -31.429 -23.041 1.00 7.75 ? 54 ALA B N 1 ATOM 3409 C CA . ALA B 1 70 ? -7.338 -31.788 -21.695 1.00 6.70 ? 54 ALA B CA 1 ATOM 3410 C C . ALA B 1 70 ? -6.265 -31.780 -20.611 1.00 6.09 ? 54 ALA B C 1 ATOM 3411 O O . ALA B 1 70 ? -5.137 -32.214 -20.815 1.00 7.84 ? 54 ALA B O 1 ATOM 3412 C CB . ALA B 1 70 ? -8.024 -33.151 -21.717 1.00 4.42 ? 54 ALA B CB 1 ATOM 3413 N N . VAL B 1 71 ? -6.629 -31.308 -19.430 1.00 7.01 ? 55 VAL B N 1 ATOM 3414 C CA . VAL B 1 71 ? -5.738 -31.442 -18.300 1.00 8.20 ? 55 VAL B CA 1 ATOM 3415 C C . VAL B 1 71 ? -5.778 -32.872 -17.806 1.00 6.62 ? 55 VAL B C 1 ATOM 3416 O O . VAL B 1 71 ? -6.836 -33.449 -17.600 1.00 7.84 ? 55 VAL B O 1 ATOM 3417 C CB . VAL B 1 71 ? -6.097 -30.479 -17.172 1.00 12.54 ? 55 VAL B CB 1 ATOM 3418 C CG1 . VAL B 1 71 ? -5.285 -30.798 -15.937 1.00 8.94 ? 55 VAL B CG1 1 ATOM 3419 C CG2 . VAL B 1 71 ? -5.851 -29.057 -17.614 1.00 11.67 ? 55 VAL B CG2 1 ATOM 3420 N N . LEU B 1 72 ? -4.606 -33.449 -17.627 1.00 7.47 ? 56 LEU B N 1 ATOM 3421 C CA . LEU B 1 72 ? -4.502 -34.783 -17.092 1.00 9.33 ? 56 LEU B CA 1 ATOM 3422 C C . LEU B 1 72 ? -4.526 -34.749 -15.540 1.00 9.22 ? 56 LEU B C 1 ATOM 3423 O O . LEU B 1 72 ? -5.349 -35.386 -14.889 1.00 9.64 ? 56 LEU B O 1 ATOM 3424 C CB . LEU B 1 72 ? -3.219 -35.397 -17.634 1.00 8.61 ? 56 LEU B CB 1 ATOM 3425 C CG . LEU B 1 72 ? -3.157 -36.891 -17.857 1.00 13.66 ? 56 LEU B CG 1 ATOM 3426 C CD1 . LEU B 1 72 ? -4.152 -37.371 -18.933 1.00 13.36 ? 56 LEU B CD1 1 ATOM 3427 C CD2 . LEU B 1 72 ? -1.710 -37.211 -18.242 1.00 13.57 ? 56 LEU B CD2 1 ATOM 3428 N N . ARG B 1 73 ? -3.618 -33.981 -14.966 1.00 10.04 ? 57 ARG B N 1 ATOM 3429 C CA . ARG B 1 73 ? -3.526 -33.792 -13.535 1.00 10.48 ? 57 ARG B CA 1 ATOM 3430 C C . ARG B 1 73 ? -3.005 -32.383 -13.322 1.00 8.48 ? 57 ARG B C 1 ATOM 3431 O O . ARG B 1 73 ? -2.293 -31.836 -14.166 1.00 8.01 ? 57 ARG B O 1 ATOM 3432 C CB . ARG B 1 73 ? -2.528 -34.758 -12.876 1.00 11.06 ? 57 ARG B CB 1 ATOM 3433 C CG . ARG B 1 73 ? -3.017 -36.177 -12.597 1.00 16.90 ? 57 ARG B CG 1 ATOM 3434 C CD . ARG B 1 73 ? -1.958 -36.978 -11.789 1.00 13.18 ? 57 ARG B CD 1 ATOM 3435 N NE . ARG B 1 73 ? -2.239 -38.417 -11.738 1.00 15.01 ? 57 ARG B NE 1 ATOM 3436 C CZ . ARG B 1 73 ? -1.391 -39.330 -11.282 1.00 14.29 ? 57 ARG B CZ 1 ATOM 3437 N NH1 . ARG B 1 73 ? -0.198 -38.975 -10.826 1.00 18.33 ? 57 ARG B NH1 1 ATOM 3438 N NH2 . ARG B 1 73 ? -1.741 -40.604 -11.286 1.00 19.38 ? 57 ARG B NH2 1 ATOM 3439 N N . LYS B 1 74 ? -3.322 -31.826 -12.164 1.00 10.56 ? 58 LYS B N 1 ATOM 3440 C CA . LYS B 1 74 ? -2.744 -30.584 -11.698 1.00 10.33 ? 58 LYS B CA 1 ATOM 3441 C C . LYS B 1 74 ? -1.834 -30.900 -10.504 1.00 10.62 ? 58 LYS B C 1 ATOM 3442 O O . LYS B 1 74 ? -2.190 -31.729 -9.672 1.00 12.62 ? 58 LYS B O 1 ATOM 3443 C CB . LYS B 1 74 ? -3.862 -29.631 -11.272 1.00 11.19 ? 58 LYS B CB 1 ATOM 3444 C CG . LYS B 1 74 ? -5.026 -29.553 -12.237 1.00 12.48 ? 58 LYS B CG 1 ATOM 3445 C CD . LYS B 1 74 ? -6.256 -28.872 -11.619 1.00 20.39 ? 58 LYS B CD 1 ATOM 3446 C CE . LYS B 1 74 ? -7.403 -28.684 -12.636 1.00 22.82 ? 58 LYS B CE 1 ATOM 3447 N NZ . LYS B 1 74 ? -8.633 -28.053 -12.045 1.00 23.05 ? 58 LYS B NZ 1 ATOM 3448 N N . LEU B 1 75 ? -0.666 -30.258 -10.430 1.00 15.53 ? 59 LEU B N 1 ATOM 3449 C CA . LEU B 1 75 ? 0.288 -30.431 -9.312 1.00 11.94 ? 59 LEU B CA 1 ATOM 3450 C C . LEU B 1 75 ? 0.526 -29.126 -8.548 1.00 12.46 ? 59 LEU B C 1 ATOM 3451 O O . LEU B 1 75 ? 0.627 -28.068 -9.152 1.00 13.18 ? 59 LEU B O 1 ATOM 3452 C CB . LEU B 1 75 ? 1.642 -30.919 -9.818 1.00 13.13 ? 59 LEU B CB 1 ATOM 3453 C CG . LEU B 1 75 ? 1.683 -32.185 -10.664 1.00 14.24 ? 59 LEU B CG 1 ATOM 3454 C CD1 . LEU B 1 75 ? 3.110 -32.606 -11.005 1.00 13.62 ? 59 LEU B CD1 1 ATOM 3455 C CD2 . LEU B 1 75 ? 0.981 -33.273 -9.921 1.00 17.05 ? 59 LEU B CD2 1 ATOM 3456 N N . CYS B 1 76 ? 0.634 -29.213 -7.223 1.00 13.67 ? 60 CYS B N 1 ATOM 3457 C CA . CYS B 1 76 ? 0.889 -28.040 -6.401 1.00 13.91 ? 60 CYS B CA 1 ATOM 3458 C C . CYS B 1 76 ? 2.366 -27.943 -6.083 1.00 13.88 ? 60 CYS B C 1 ATOM 3459 O O . CYS B 1 76 ? 2.966 -28.890 -5.598 1.00 15.04 ? 60 CYS B O 1 ATOM 3460 C CB . CYS B 1 76 ? 0.100 -28.094 -5.092 1.00 17.70 ? 60 CYS B CB 1 ATOM 3461 S SG . CYS B 1 76 ? -0.057 -26.475 -4.295 1.00 19.96 ? 60 CYS B SG 1 ATOM 3462 N N . ILE B 1 77 ? 2.944 -26.785 -6.357 1.00 12.95 ? 61 ILE B N 1 ATOM 3463 C CA . ILE B 1 77 ? 4.348 -26.542 -6.060 1.00 21.19 ? 61 ILE B CA 1 ATOM 3464 C C . ILE B 1 77 ? 4.525 -25.553 -4.889 1.00 18.77 ? 61 ILE B C 1 ATOM 3465 O O . ILE B 1 77 ? 5.587 -25.470 -4.296 1.00 21.13 ? 61 ILE B O 1 ATOM 3466 C CB . ILE B 1 77 ? 5.100 -26.034 -7.301 1.00 18.84 ? 61 ILE B CB 1 ATOM 3467 C CG1 . ILE B 1 77 ? 4.492 -24.730 -7.785 1.00 20.91 ? 61 ILE B CG1 1 ATOM 3468 C CG2 . ILE B 1 77 ? 5.081 -27.088 -8.419 1.00 18.80 ? 61 ILE B CG2 1 ATOM 3469 C CD1 . ILE B 1 77 ? 5.102 -24.239 -9.054 1.00 26.65 ? 61 ILE B CD1 1 ATOM 3470 N N . GLU B 1 78 ? 3.479 -24.816 -4.547 1.00 22.52 ? 62 GLU B N 1 ATOM 3471 C CA . GLU B 1 78 ? 3.491 -24.007 -3.334 1.00 23.58 ? 62 GLU B CA 1 ATOM 3472 C C . GLU B 1 78 ? 2.102 -23.993 -2.734 1.00 21.32 ? 62 GLU B C 1 ATOM 3473 O O . GLU B 1 78 ? 1.140 -23.624 -3.400 1.00 22.04 ? 62 GLU B O 1 ATOM 3474 C CB . GLU B 1 78 ? 3.916 -22.577 -3.632 1.00 25.03 ? 62 GLU B CB 1 ATOM 3475 C CG . GLU B 1 78 ? 4.306 -21.776 -2.388 1.00 24.07 ? 62 GLU B CG 1 ATOM 3476 C CD . GLU B 1 78 ? 4.078 -20.266 -2.555 1.00 32.89 ? 62 GLU B CD 1 ATOM 3477 O OE1 . GLU B 1 78 ? 3.184 -19.891 -3.343 1.00 36.31 ? 62 GLU B OE1 1 ATOM 3478 O OE2 . GLU B 1 78 ? 4.783 -19.455 -1.907 1.00 36.77 ? 62 GLU B OE2 1 ATOM 3479 N N . ALA B 1 79 ? 2.001 -24.407 -1.477 1.00 28.27 ? 63 ALA B N 1 ATOM 3480 C CA . ALA B 1 79 ? 0.739 -24.343 -0.755 1.00 26.32 ? 63 ALA B CA 1 ATOM 3481 C C . ALA B 1 79 ? 0.834 -23.294 0.357 1.00 26.44 ? 63 ALA B C 1 ATOM 3482 O O . ALA B 1 79 ? 1.932 -22.941 0.795 1.00 26.39 ? 63 ALA B O 1 ATOM 3483 C CB . ALA B 1 79 ? 0.376 -25.717 -0.190 1.00 22.09 ? 63 ALA B CB 1 ATOM 3484 N N . LYS B 1 80 ? -0.315 -22.772 0.774 1.00 26.13 ? 64 LYS B N 1 ATOM 3485 C CA . LYS B 1 80 ? -0.398 -21.977 1.991 1.00 29.32 ? 64 LYS B CA 1 ATOM 3486 C C . LYS B 1 80 ? -1.280 -22.711 2.973 1.00 24.60 ? 64 LYS B C 1 ATOM 3487 O O . LYS B 1 80 ? -2.284 -23.284 2.592 1.00 26.48 ? 64 LYS B O 1 ATOM 3488 C CB . LYS B 1 80 ? -0.976 -20.589 1.712 1.00 31.06 ? 64 LYS B CB 1 ATOM 3489 C CG . LYS B 1 80 ? 0.035 -19.608 1.156 1.00 32.33 ? 64 LYS B CG 1 ATOM 3490 C CD . LYS B 1 80 ? -0.553 -18.211 0.946 1.00 31.48 ? 64 LYS B CD 1 ATOM 3491 C CE . LYS B 1 80 ? 0.542 -17.234 0.488 1.00 40.36 ? 64 LYS B CE 1 ATOM 3492 N NZ . LYS B 1 80 ? 0.277 -15.780 0.781 1.00 36.21 ? 64 LYS B NZ 1 ATOM 3493 N N . ILE B 1 81 ? -0.893 -22.705 4.239 1.00 27.83 ? 65 ILE B N 1 ATOM 3494 C CA . ILE B 1 81 ? -1.703 -23.326 5.271 1.00 32.37 ? 65 ILE B CA 1 ATOM 3495 C C . ILE B 1 81 ? -2.344 -22.232 6.130 1.00 32.15 ? 65 ILE B C 1 ATOM 3496 O O . ILE B 1 81 ? -1.740 -21.178 6.348 1.00 33.56 ? 65 ILE B O 1 ATOM 3497 C CB . ILE B 1 81 ? -0.878 -24.302 6.128 1.00 29.80 ? 65 ILE B CB 1 ATOM 3498 C CG1 . ILE B 1 81 ? -0.693 -25.629 5.394 1.00 28.66 ? 65 ILE B CG1 1 ATOM 3499 C CG2 . ILE B 1 81 ? -1.582 -24.575 7.413 1.00 32.03 ? 65 ILE B CG2 1 ATOM 3500 C CD1 . ILE B 1 81 ? -1.985 -26.398 5.155 1.00 27.94 ? 65 ILE B CD1 1 ATOM 3501 N N . SER B 1 82 ? -3.574 -22.459 6.585 1.00 26.87 ? 66 SER B N 1 ATOM 3502 C CA . SER B 1 82 ? -4.276 -21.453 7.364 1.00 29.49 ? 66 SER B CA 1 ATOM 3503 C C . SER B 1 82 ? -5.273 -22.063 8.325 1.00 29.00 ? 66 SER B C 1 ATOM 3504 O O . SER B 1 82 ? -5.851 -23.106 8.050 1.00 32.86 ? 66 SER B O 1 ATOM 3505 C CB . SER B 1 82 ? -5.037 -20.503 6.449 1.00 31.30 ? 66 SER B CB 1 ATOM 3506 O OG . SER B 1 82 ? -4.200 -19.904 5.482 1.00 41.75 ? 66 SER B OG 1 ATOM 3507 N N . ASN B 1 83 ? -5.500 -21.390 9.446 1.00 29.70 ? 67 ASN B N 1 ATOM 3508 C CA . ASN B 1 83 ? -6.597 -21.764 10.327 1.00 32.14 ? 67 ASN B CA 1 ATOM 3509 C C . ASN B 1 83 ? -6.341 -23.115 10.970 1.00 28.12 ? 67 ASN B C 1 ATOM 3510 O O . ASN B 1 83 ? -7.240 -23.934 11.144 1.00 23.70 ? 67 ASN B O 1 ATOM 3511 C CB . ASN B 1 83 ? -7.923 -21.780 9.560 1.00 30.61 ? 67 ASN B CB 1 ATOM 3512 C CG . ASN B 1 83 ? -8.177 -20.485 8.810 1.00 40.88 ? 67 ASN B CG 1 ATOM 3513 O OD1 . ASN B 1 83 ? -7.681 -20.297 7.704 1.00 45.10 ? 67 ASN B OD1 1 ATOM 3514 N ND2 . ASN B 1 83 ? -8.957 -19.585 9.406 1.00 45.67 ? 67 ASN B ND2 1 ATOM 3515 N N . THR B 1 84 ? -5.088 -23.326 11.324 1.00 27.50 ? 68 THR B N 1 ATOM 3516 C CA . THR B 1 84 ? -4.670 -24.513 12.029 1.00 25.59 ? 68 THR B CA 1 ATOM 3517 C C . THR B 1 84 ? -5.364 -24.611 13.379 1.00 28.35 ? 68 THR B C 1 ATOM 3518 O O . THR B 1 84 ? -5.439 -23.637 14.124 1.00 30.39 ? 68 THR B O 1 ATOM 3519 C CB . THR B 1 84 ? -3.184 -24.437 12.248 1.00 30.42 ? 68 THR B CB 1 ATOM 3520 O OG1 . THR B 1 84 ? -2.575 -23.956 11.040 1.00 28.16 ? 68 THR B OG1 1 ATOM 3521 C CG2 . THR B 1 84 ? -2.635 -25.805 12.630 1.00 33.91 ? 68 THR B CG2 1 ATOM 3522 N N . THR B 1 85 ? -5.885 -25.784 13.698 1.00 28.25 ? 69 THR B N 1 ATOM 3523 C CA . THR B 1 85 ? -6.681 -25.929 14.906 1.00 26.29 ? 69 THR B CA 1 ATOM 3524 C C . THR B 1 85 ? -6.508 -27.314 15.478 1.00 24.77 ? 69 THR B C 1 ATOM 3525 O O . THR B 1 85 ? -6.426 -28.284 14.739 1.00 24.19 ? 69 THR B O 1 ATOM 3526 C CB . THR B 1 85 ? -8.184 -25.689 14.633 1.00 28.57 ? 69 THR B CB 1 ATOM 3527 O OG1 . THR B 1 85 ? -8.727 -26.766 13.853 1.00 32.16 ? 69 THR B OG1 1 ATOM 3528 C CG2 . THR B 1 85 ? -8.382 -24.401 13.888 1.00 28.06 ? 69 THR B CG2 1 ATOM 3529 N N . THR B 1 86 ? -6.483 -27.395 16.805 1.00 22.78 ? 70 THR B N 1 ATOM 3530 C CA . THR B 1 86 ? -6.231 -28.647 17.512 1.00 25.81 ? 70 THR B CA 1 ATOM 3531 C C . THR B 1 86 ? -7.335 -28.982 18.517 1.00 23.86 ? 70 THR B C 1 ATOM 3532 O O . THR B 1 86 ? -7.938 -28.090 19.107 1.00 28.35 ? 70 THR B O 1 ATOM 3533 C CB . THR B 1 86 ? -4.901 -28.567 18.263 1.00 23.57 ? 70 THR B CB 1 ATOM 3534 O OG1 . THR B 1 86 ? -3.870 -28.148 17.368 1.00 20.05 ? 70 THR B OG1 1 ATOM 3535 C CG2 . THR B 1 86 ? -4.537 -29.903 18.860 1.00 28.49 ? 70 THR B CG2 1 ATOM 3536 N N . ASP B 1 87 ? -7.601 -30.276 18.667 1.00 22.66 ? 71 ASP B N 1 ATOM 3537 C CA . ASP B 1 87 ? -8.531 -30.804 19.650 1.00 24.09 ? 71 ASP B CA 1 ATOM 3538 C C . ASP B 1 87 ? -7.784 -31.910 20.408 1.00 25.01 ? 71 ASP B C 1 ATOM 3539 O O . ASP B 1 87 ? -6.959 -32.608 19.836 1.00 24.20 ? 71 ASP B O 1 ATOM 3540 C CB . ASP B 1 87 ? -9.764 -31.371 18.950 1.00 24.60 ? 71 ASP B CB 1 ATOM 3541 C CG . ASP B 1 87 ? -10.897 -31.686 19.906 1.00 31.87 ? 71 ASP B CG 1 ATOM 3542 O OD1 . ASP B 1 87 ? -10.842 -32.761 20.537 1.00 27.62 ? 71 ASP B OD1 1 ATOM 3543 O OD2 . ASP B 1 87 ? -11.862 -30.883 20.005 1.00 39.56 ? 71 ASP B OD2 1 ATOM 3544 N N . SER B 1 88 ? -8.060 -32.085 21.692 1.00 25.98 ? 72 SER B N 1 ATOM 3545 C CA . SER B 1 88 ? -7.244 -32.984 22.491 1.00 23.35 ? 72 SER B CA 1 ATOM 3546 C C . SER B 1 88 ? -7.955 -33.499 23.728 1.00 28.43 ? 72 SER B C 1 ATOM 3547 O O . SER B 1 88 ? -8.528 -32.713 24.476 1.00 28.64 ? 72 SER B O 1 ATOM 3548 C CB . SER B 1 88 ? -5.977 -32.264 22.919 1.00 25.63 ? 72 SER B CB 1 ATOM 3549 O OG . SER B 1 88 ? -5.475 -32.833 24.102 1.00 30.82 ? 72 SER B OG 1 ATOM 3550 N N . ARG B 1 89 ? -7.889 -34.816 23.936 1.00 25.42 ? 73 ARG B N 1 ATOM 3551 C CA . ARG B 1 89 ? -8.585 -35.493 25.023 1.00 26.88 ? 73 ARG B CA 1 ATOM 3552 C C . ARG B 1 89 ? -7.588 -35.982 26.059 1.00 25.37 ? 73 ARG B C 1 ATOM 3553 O O . ARG B 1 89 ? -6.414 -36.132 25.762 1.00 26.84 ? 73 ARG B O 1 ATOM 3554 C CB . ARG B 1 89 ? -9.374 -36.685 24.483 1.00 29.30 ? 73 ARG B CB 1 ATOM 3555 C CG . ARG B 1 89 ? -10.096 -36.417 23.168 1.00 30.03 ? 73 ARG B CG 1 ATOM 3556 C CD . ARG B 1 89 ? -11.278 -35.501 23.320 1.00 28.44 ? 73 ARG B CD 1 ATOM 3557 N NE . ARG B 1 89 ? -12.454 -36.194 23.836 1.00 35.18 ? 73 ARG B NE 1 ATOM 3558 C CZ . ARG B 1 89 ? -13.538 -35.585 24.317 1.00 37.71 ? 73 ARG B CZ 1 ATOM 3559 N NH1 . ARG B 1 89 ? -13.603 -34.258 24.361 1.00 34.50 ? 73 ARG B NH1 1 ATOM 3560 N NH2 . ARG B 1 89 ? -14.555 -36.306 24.772 1.00 38.37 ? 73 ARG B NH2 1 ATOM 3561 N N . CYS B 1 90 ? -8.044 -36.200 27.286 1.00 28.88 ? 74 CYS B N 1 ATOM 3562 C CA . CYS B 1 90 ? -7.154 -36.647 28.352 1.00 27.25 ? 74 CYS B CA 1 ATOM 3563 C C . CYS B 1 90 ? -7.015 -38.144 28.325 1.00 25.19 ? 74 CYS B C 1 ATOM 3564 O O . CYS B 1 90 ? -7.741 -38.816 27.602 1.00 26.55 ? 74 CYS B O 1 ATOM 3565 C CB . CYS B 1 90 ? -7.667 -36.205 29.719 1.00 24.89 ? 74 CYS B CB 1 ATOM 3566 S SG . CYS B 1 90 ? -7.417 -34.469 30.002 1.00 25.24 ? 74 CYS B SG 1 ATOM 3567 N N . PRO B 1 91 ? -6.071 -38.676 29.111 1.00 28.12 ? 75 PRO B N 1 ATOM 3568 C CA . PRO B 1 91 ? -5.955 -40.128 29.231 1.00 29.23 ? 75 PRO B CA 1 ATOM 3569 C C . PRO B 1 91 ? -7.245 -40.743 29.770 1.00 32.16 ? 75 PRO B C 1 ATOM 3570 O O . PRO B 1 91 ? -7.641 -40.472 30.904 1.00 37.84 ? 75 PRO B O 1 ATOM 3571 C CB . PRO B 1 91 ? -4.802 -40.306 30.225 1.00 26.21 ? 75 PRO B CB 1 ATOM 3572 C CG . PRO B 1 91 ? -4.029 -39.056 30.123 1.00 24.69 ? 75 PRO B CG 1 ATOM 3573 C CD . PRO B 1 91 ? -5.020 -37.984 29.872 1.00 26.29 ? 75 PRO B CD 1 ATOM 3574 N N . THR B 1 92 ? -7.894 -41.551 28.940 1.00 32.68 ? 76 THR B N 1 ATOM 3575 C CA . THR B 1 92 ? -9.133 -42.257 29.282 1.00 30.71 ? 76 THR B CA 1 ATOM 3576 C C . THR B 1 92 ? -10.371 -41.634 28.639 1.00 29.56 ? 76 THR B C 1 ATOM 3577 O O . THR B 1 92 ? -11.416 -42.263 28.602 1.00 26.86 ? 76 THR B O 1 ATOM 3578 C CB . THR B 1 92 ? -9.346 -42.446 30.815 1.00 33.74 ? 76 THR B CB 1 ATOM 3579 O OG1 . THR B 1 92 ? -9.628 -41.199 31.470 1.00 28.42 ? 76 THR B OG1 1 ATOM 3580 C CG2 . THR B 1 92 ? -8.134 -43.118 31.450 1.00 32.08 ? 76 THR B CG2 1 ATOM 3581 N N . GLN B 1 93 ? -10.248 -40.433 28.083 1.00 27.44 ? 77 GLN B N 1 ATOM 3582 C CA . GLN B 1 93 ? -11.414 -39.728 27.562 1.00 28.40 ? 77 GLN B CA 1 ATOM 3583 C C . GLN B 1 93 ? -11.602 -39.834 26.049 1.00 33.44 ? 77 GLN B C 1 ATOM 3584 O O . GLN B 1 93 ? -12.139 -38.924 25.429 1.00 35.41 ? 77 GLN B O 1 ATOM 3585 C CB . GLN B 1 93 ? -11.348 -38.256 27.946 1.00 29.95 ? 77 GLN B CB 1 ATOM 3586 C CG . GLN B 1 93 ? -10.685 -37.990 29.286 1.00 36.83 ? 77 GLN B CG 1 ATOM 3587 C CD . GLN B 1 93 ? -11.194 -38.899 30.387 1.00 35.92 ? 77 GLN B CD 1 ATOM 3588 O OE1 . GLN B 1 93 ? -10.409 -39.586 31.049 1.00 38.24 ? 77 GLN B OE1 1 ATOM 3589 N NE2 . GLN B 1 93 ? -12.506 -38.909 30.591 1.00 29.42 ? 77 GLN B NE2 1 ATOM 3590 N N . GLY B 1 94 ? -11.165 -40.935 25.453 1.00 35.64 ? 78 GLY B N 1 ATOM 3591 C CA . GLY B 1 94 ? -11.449 -41.190 24.053 1.00 42.67 ? 78 GLY B CA 1 ATOM 3592 C C . GLY B 1 94 ? -10.762 -40.259 23.063 1.00 39.76 ? 78 GLY B C 1 ATOM 3593 O O . GLY B 1 94 ? -10.154 -39.246 23.427 1.00 33.49 ? 78 GLY B O 1 ATOM 3594 N N . GLU B 1 95 ? -10.886 -40.616 21.788 1.00 39.97 ? 79 GLU B N 1 ATOM 3595 C CA . GLU B 1 95 ? -10.122 -39.993 20.717 1.00 33.27 ? 79 GLU B CA 1 ATOM 3596 C C . GLU B 1 95 ? -10.570 -38.553 20.499 1.00 27.50 ? 79 GLU B C 1 ATOM 3597 O O . GLU B 1 95 ? -11.725 -38.219 20.759 1.00 28.74 ? 79 GLU B O 1 ATOM 3598 C CB . GLU B 1 95 ? -10.315 -40.802 19.428 1.00 41.26 ? 79 GLU B CB 1 ATOM 3599 C CG . GLU B 1 95 ? -9.015 -41.190 18.706 1.00 41.00 ? 79 GLU B CG 1 ATOM 3600 C CD . GLU B 1 95 ? -8.074 -42.031 19.560 1.00 40.41 ? 79 GLU B CD 1 ATOM 3601 O OE1 . GLU B 1 95 ? -8.369 -42.256 20.751 1.00 43.29 ? 79 GLU B OE1 1 ATOM 3602 O OE2 . GLU B 1 95 ? -7.025 -42.464 19.044 1.00 45.99 ? 79 GLU B OE2 1 ATOM 3603 N N . ALA B 1 96 ? -9.661 -37.707 20.016 1.00 24.14 ? 80 ALA B N 1 ATOM 3604 C CA . ALA B 1 96 ? -9.983 -36.300 19.749 1.00 28.91 ? 80 ALA B CA 1 ATOM 3605 C C . ALA B 1 96 ? -10.695 -36.139 18.402 1.00 27.21 ? 80 ALA B C 1 ATOM 3606 O O . ALA B 1 96 ? -10.839 -37.113 17.656 1.00 24.33 ? 80 ALA B O 1 ATOM 3607 C CB . ALA B 1 96 ? -8.732 -35.422 19.824 1.00 27.42 ? 80 ALA B CB 1 ATOM 3608 N N . THR B 1 97 ? -11.155 -34.912 18.129 1.00 29.47 ? 81 THR B N 1 ATOM 3609 C CA . THR B 1 97 ? -12.112 -34.635 17.053 1.00 22.41 ? 81 THR B CA 1 ATOM 3610 C C . THR B 1 97 ? -12.156 -33.154 16.690 1.00 27.80 ? 81 THR B C 1 ATOM 3611 O O . THR B 1 97 ? -12.243 -32.284 17.551 1.00 27.82 ? 81 THR B O 1 ATOM 3612 C CB . THR B 1 97 ? -13.546 -35.094 17.443 1.00 24.20 ? 81 THR B CB 1 ATOM 3613 O OG1 . THR B 1 97 ? -14.106 -35.885 16.394 1.00 27.74 ? 81 THR B OG1 1 ATOM 3614 C CG2 . THR B 1 97 ? -14.457 -33.916 17.710 1.00 22.97 ? 81 THR B CG2 1 ATOM 3615 N N . LEU B 1 98 ? -12.129 -32.868 15.398 1.00 28.74 ? 82 LEU B N 1 ATOM 3616 C CA . LEU B 1 98 ? -12.229 -31.495 14.931 1.00 25.94 ? 82 LEU B CA 1 ATOM 3617 C C . LEU B 1 98 ? -13.298 -31.310 13.869 1.00 27.76 ? 82 LEU B C 1 ATOM 3618 O O . LEU B 1 98 ? -13.498 -32.163 13.009 1.00 25.63 ? 82 LEU B O 1 ATOM 3619 C CB . LEU B 1 98 ? -10.895 -31.056 14.362 1.00 24.34 ? 82 LEU B CB 1 ATOM 3620 C CG . LEU B 1 98 ? -9.917 -30.461 15.362 1.00 22.97 ? 82 LEU B CG 1 ATOM 3621 C CD1 . LEU B 1 98 ? -8.585 -30.261 14.674 1.00 20.65 ? 82 LEU B CD1 1 ATOM 3622 C CD2 . LEU B 1 98 ? -10.434 -29.144 15.934 1.00 23.98 ? 82 LEU B CD2 1 ATOM 3623 N N . VAL B 1 99 ? -13.980 -30.176 13.935 1.00 30.71 ? 83 VAL B N 1 ATOM 3624 C CA . VAL B 1 99 ? -14.934 -29.799 12.907 1.00 30.85 ? 83 VAL B CA 1 ATOM 3625 C C . VAL B 1 99 ? -14.214 -29.729 11.570 1.00 30.63 ? 83 VAL B C 1 ATOM 3626 O O . VAL B 1 99 ? -14.781 -30.004 10.527 1.00 30.57 ? 83 VAL B O 1 ATOM 3627 C CB . VAL B 1 99 ? -15.560 -28.425 13.210 1.00 28.13 ? 83 VAL B CB 1 ATOM 3628 C CG1 . VAL B 1 99 ? -14.721 -27.285 12.626 1.00 29.76 ? 83 VAL B CG1 1 ATOM 3629 C CG2 . VAL B 1 99 ? -16.957 -28.371 12.676 1.00 24.79 ? 83 VAL B CG2 1 ATOM 3630 N N . GLU B 1 100 ? -12.955 -29.334 11.607 1.00 27.29 ? 84 GLU B N 1 ATOM 3631 C CA . GLU B 1 100 ? -12.154 -29.295 10.404 1.00 28.18 ? 84 GLU B CA 1 ATOM 3632 C C . GLU B 1 100 ? -11.973 -30.687 9.812 1.00 25.41 ? 84 GLU B C 1 ATOM 3633 O O . GLU B 1 100 ? -11.638 -30.816 8.651 1.00 26.73 ? 84 GLU B O 1 ATOM 3634 C CB . GLU B 1 100 ? -10.805 -28.670 10.699 1.00 26.91 ? 84 GLU B CB 1 ATOM 3635 N N . GLU B 1 101 ? -12.211 -31.734 10.590 1.00 30.30 ? 85 GLU B N 1 ATOM 3636 C CA . GLU B 1 101 ? -11.965 -33.080 10.085 1.00 29.82 ? 85 GLU B CA 1 ATOM 3637 C C . GLU B 1 101 ? -12.735 -33.280 8.819 1.00 31.78 ? 85 GLU B C 1 ATOM 3638 O O . GLU B 1 101 ? -12.393 -34.146 8.034 1.00 35.67 ? 85 GLU B O 1 ATOM 3639 C CB . GLU B 1 101 ? -12.403 -34.165 11.062 1.00 33.43 ? 85 GLU B CB 1 ATOM 3640 C CG . GLU B 1 101 ? -11.503 -34.385 12.240 1.00 31.18 ? 85 GLU B CG 1 ATOM 3641 C CD . GLU B 1 101 ? -11.946 -35.581 13.062 1.00 31.87 ? 85 GLU B CD 1 ATOM 3642 O OE1 . GLU B 1 101 ? -12.844 -35.428 13.913 1.00 28.10 ? 85 GLU B OE1 1 ATOM 3643 O OE2 . GLU B 1 101 ? -11.396 -36.682 12.845 1.00 38.45 ? 85 GLU B OE2 1 ATOM 3644 N N . GLN B 1 102 ? -13.776 -32.478 8.617 1.00 34.78 ? 86 GLN B N 1 ATOM 3645 C CA . GLN B 1 102 ? -14.723 -32.728 7.536 1.00 36.71 ? 86 GLN B CA 1 ATOM 3646 C C . GLN B 1 102 ? -14.360 -32.004 6.218 1.00 35.13 ? 86 GLN B C 1 ATOM 3647 O O . GLN B 1 102 ? -14.266 -32.636 5.168 1.00 37.88 ? 86 GLN B O 1 ATOM 3648 C CB . GLN B 1 102 ? -16.164 -32.393 7.978 1.00 38.91 ? 86 GLN B CB 1 ATOM 3649 C CG . GLN B 1 102 ? -16.366 -32.100 9.472 1.00 38.74 ? 86 GLN B CG 1 ATOM 3650 C CD . GLN B 1 102 ? -15.691 -33.104 10.432 1.00 34.57 ? 86 GLN B CD 1 ATOM 3651 O OE1 . GLN B 1 102 ? -15.322 -32.751 11.554 1.00 37.57 ? 86 GLN B OE1 1 ATOM 3652 N NE2 . GLN B 1 102 ? -15.554 -34.350 10.001 1.00 33.79 ? 86 GLN B NE2 1 ATOM 3653 N N . ASP B 1 103 ? -14.147 -30.694 6.276 1.00 35.64 ? 87 ASP B N 1 ATOM 3654 C CA . ASP B 1 103 ? -13.815 -29.921 5.093 1.00 26.97 ? 87 ASP B CA 1 ATOM 3655 C C . ASP B 1 103 ? -12.553 -30.494 4.459 1.00 32.44 ? 87 ASP B C 1 ATOM 3656 O O . ASP B 1 103 ? -11.503 -30.583 5.097 1.00 28.30 ? 87 ASP B O 1 ATOM 3657 C CB . ASP B 1 103 ? -13.627 -28.446 5.465 1.00 29.95 ? 87 ASP B CB 1 ATOM 3658 C CG . ASP B 1 103 ? -13.497 -27.545 4.255 1.00 34.62 ? 87 ASP B CG 1 ATOM 3659 O OD1 . ASP B 1 103 ? -13.746 -28.023 3.128 1.00 32.17 ? 87 ASP B OD1 1 ATOM 3660 O OD2 . ASP B 1 103 ? -13.160 -26.354 4.432 1.00 31.68 ? 87 ASP B OD2 1 ATOM 3661 N N . THR B 1 104 ? -12.664 -30.892 3.194 1.00 36.55 ? 88 THR B N 1 ATOM 3662 C CA . THR B 1 104 ? -11.546 -31.505 2.478 1.00 36.12 ? 88 THR B CA 1 ATOM 3663 C C . THR B 1 104 ? -10.348 -30.558 2.354 1.00 33.73 ? 88 THR B C 1 ATOM 3664 O O . THR B 1 104 ? -9.216 -31.000 2.177 1.00 36.95 ? 88 THR B O 1 ATOM 3665 C CB . THR B 1 104 ? -11.967 -32.031 1.066 1.00 39.45 ? 88 THR B CB 1 ATOM 3666 O OG1 . THR B 1 104 ? -12.769 -31.058 0.381 1.00 34.30 ? 88 THR B OG1 1 ATOM 3667 C CG2 . THR B 1 104 ? -12.754 -33.316 1.192 1.00 36.92 ? 88 THR B CG2 1 ATOM 3668 N N . ASN B 1 105 ? -10.594 -29.261 2.468 1.00 30.10 ? 89 ASN B N 1 ATOM 3669 C CA . ASN B 1 105 ? -9.526 -28.283 2.334 1.00 32.11 ? 89 ASN B CA 1 ATOM 3670 C C . ASN B 1 105 ? -8.541 -28.333 3.503 1.00 27.37 ? 89 ASN B C 1 ATOM 3671 O O . ASN B 1 105 ? -7.505 -27.654 3.489 1.00 27.94 ? 89 ASN B O 1 ATOM 3672 C CB . ASN B 1 105 ? -10.132 -26.889 2.149 1.00 29.75 ? 89 ASN B CB 1 ATOM 3673 C CG . ASN B 1 105 ? -11.104 -26.837 0.971 1.00 36.86 ? 89 ASN B CG 1 ATOM 3674 O OD1 . ASN B 1 105 ? -12.256 -27.258 1.088 1.00 43.16 ? 89 ASN B OD1 1 ATOM 3675 N ND2 . ASN B 1 105 ? -10.639 -26.334 -0.169 1.00 28.54 ? 89 ASN B ND2 1 ATOM 3676 N N . PHE B 1 106 ? -8.858 -29.155 4.503 1.00 28.95 ? 90 PHE B N 1 ATOM 3677 C CA . PHE B 1 106 ? -7.995 -29.326 5.667 1.00 23.88 ? 90 PHE B CA 1 ATOM 3678 C C . PHE B 1 106 ? -7.136 -30.558 5.575 1.00 26.72 ? 90 PHE B C 1 ATOM 3679 O O . PHE B 1 106 ? -7.586 -31.632 5.192 1.00 26.92 ? 90 PHE B O 1 ATOM 3680 C CB . PHE B 1 106 ? -8.808 -29.419 6.950 1.00 26.49 ? 90 PHE B CB 1 ATOM 3681 C CG . PHE B 1 106 ? -9.429 -28.133 7.353 1.00 26.85 ? 90 PHE B CG 1 ATOM 3682 C CD1 . PHE B 1 106 ? -8.657 -27.031 7.625 1.00 28.10 ? 90 PHE B CD1 1 ATOM 3683 C CD2 . PHE B 1 106 ? -10.785 -28.023 7.464 1.00 31.96 ? 90 PHE B CD2 1 ATOM 3684 C CE1 . PHE B 1 106 ? -9.224 -25.849 7.992 1.00 25.57 ? 90 PHE B CE1 1 ATOM 3685 C CE2 . PHE B 1 106 ? -11.350 -26.847 7.824 1.00 31.78 ? 90 PHE B CE2 1 ATOM 3686 C CZ . PHE B 1 106 ? -10.567 -25.751 8.087 1.00 30.53 ? 90 PHE B CZ 1 ATOM 3687 N N . VAL B 1 107 ? -5.884 -30.390 5.947 1.00 24.81 ? 91 VAL B N 1 ATOM 3688 C CA . VAL B 1 107 ? -5.010 -31.515 6.128 1.00 23.93 ? 91 VAL B CA 1 ATOM 3689 C C . VAL B 1 107 ? -4.940 -31.687 7.644 1.00 24.88 ? 91 VAL B C 1 ATOM 3690 O O . VAL B 1 107 ? -4.805 -30.711 8.378 1.00 24.28 ? 91 VAL B O 1 ATOM 3691 C CB . VAL B 1 107 ? -3.652 -31.264 5.484 1.00 20.17 ? 91 VAL B CB 1 ATOM 3692 C CG1 . VAL B 1 107 ? -3.180 -29.846 5.764 1.00 21.51 ? 91 VAL B CG1 1 ATOM 3693 C CG2 . VAL B 1 107 ? -2.670 -32.276 5.969 1.00 24.23 ? 91 VAL B CG2 1 ATOM 3694 N N . CYS B 1 108 ? -5.102 -32.911 8.123 1.00 18.39 ? 92 CYS B N 1 ATOM 3695 C CA . CYS B 1 108 ? -5.124 -33.124 9.549 1.00 19.51 ? 92 CYS B CA 1 ATOM 3696 C C . CYS B 1 108 ? -4.085 -34.123 9.882 1.00 21.16 ? 92 CYS B C 1 ATOM 3697 O O . CYS B 1 108 ? -3.435 -34.660 9.002 1.00 29.76 ? 92 CYS B O 1 ATOM 3698 C CB . CYS B 1 108 ? -6.466 -33.653 10.013 1.00 21.14 ? 92 CYS B CB 1 ATOM 3699 S SG . CYS B 1 108 ? -7.845 -32.618 9.600 1.00 29.36 ? 92 CYS B SG 1 ATOM 3700 N N . ARG B 1 109 ? -3.921 -34.370 11.166 1.00 23.00 ? 93 ARG B N 1 ATOM 3701 C CA . ARG B 1 109 ? -2.988 -35.372 11.635 1.00 21.79 ? 93 ARG B CA 1 ATOM 3702 C C . ARG B 1 109 ? -3.312 -35.677 13.079 1.00 21.74 ? 93 ARG B C 1 ATOM 3703 O O . ARG B 1 109 ? -3.493 -34.783 13.892 1.00 20.80 ? 93 ARG B O 1 ATOM 3704 C CB . ARG B 1 109 ? -1.548 -34.885 11.494 1.00 26.09 ? 93 ARG B CB 1 ATOM 3705 C CG . ARG B 1 109 ? -0.503 -35.946 11.800 1.00 28.44 ? 93 ARG B CG 1 ATOM 3706 C CD . ARG B 1 109 ? 0.845 -35.615 11.161 1.00 34.52 ? 93 ARG B CD 1 ATOM 3707 N NE . ARG B 1 109 ? 0.748 -35.553 9.701 1.00 39.59 ? 93 ARG B NE 1 ATOM 3708 C CZ . ARG B 1 109 ? 1.766 -35.311 8.878 1.00 34.28 ? 93 ARG B CZ 1 ATOM 3709 N NH1 . ARG B 1 109 ? 2.985 -35.099 9.355 1.00 30.55 ? 93 ARG B NH1 1 ATOM 3710 N NH2 . ARG B 1 109 ? 1.556 -35.274 7.569 1.00 34.29 ? 93 ARG B NH2 1 ATOM 3711 N N . ARG B 1 110 ? -3.401 -36.958 13.383 1.00 20.37 ? 94 ARG B N 1 ATOM 3712 C CA . ARG B 1 110 ? -3.748 -37.383 14.707 1.00 26.09 ? 94 ARG B CA 1 ATOM 3713 C C . ARG B 1 110 ? -2.478 -37.909 15.351 1.00 25.46 ? 94 ARG B C 1 ATOM 3714 O O . ARG B 1 110 ? -1.476 -38.117 14.681 1.00 25.98 ? 94 ARG B O 1 ATOM 3715 C CB . ARG B 1 110 ? -4.849 -38.442 14.646 1.00 26.91 ? 94 ARG B CB 1 ATOM 3716 C CG . ARG B 1 110 ? -5.514 -38.736 15.975 1.00 28.98 ? 94 ARG B CG 1 ATOM 3717 C CD . ARG B 1 110 ? -6.780 -39.537 15.781 1.00 32.62 ? 94 ARG B CD 1 ATOM 3718 N NE . ARG B 1 110 ? -7.951 -38.673 15.722 1.00 24.81 ? 94 ARG B NE 1 ATOM 3719 C CZ . ARG B 1 110 ? -8.880 -38.724 14.779 1.00 25.09 ? 94 ARG B CZ 1 ATOM 3720 N NH1 . ARG B 1 110 ? -8.800 -39.597 13.782 1.00 29.49 ? 94 ARG B NH1 1 ATOM 3721 N NH2 . ARG B 1 110 ? -9.905 -37.886 14.833 1.00 25.53 ? 94 ARG B NH2 1 ATOM 3722 N N . THR B 1 111 ? -2.512 -38.085 16.659 1.00 27.38 ? 95 THR B N 1 ATOM 3723 C CA . THR B 1 111 ? -1.352 -38.548 17.399 1.00 26.84 ? 95 THR B CA 1 ATOM 3724 C C . THR B 1 111 ? -1.716 -38.645 18.870 1.00 27.28 ? 95 THR B C 1 ATOM 3725 O O . THR B 1 111 ? -2.863 -38.418 19.243 1.00 25.44 ? 95 THR B O 1 ATOM 3726 C CB . THR B 1 111 ? -0.152 -37.601 17.231 1.00 27.32 ? 95 THR B CB 1 ATOM 3727 O OG1 . THR B 1 111 ? 0.852 -37.927 18.197 1.00 32.50 ? 95 THR B OG1 1 ATOM 3728 C CG2 . THR B 1 111 ? -0.570 -36.151 17.426 1.00 27.61 ? 95 THR B CG2 1 ATOM 3729 N N . PHE B 1 112 ? -0.734 -38.999 19.692 1.00 26.94 ? 96 PHE B N 1 ATOM 3730 C CA . PHE B 1 112 ? -0.920 -39.095 21.128 1.00 26.43 ? 96 PHE B CA 1 ATOM 3731 C C . PHE B 1 112 ? 0.132 -38.277 21.811 1.00 25.21 ? 96 PHE B C 1 ATOM 3732 O O . PHE B 1 112 ? 1.284 -38.284 21.403 1.00 29.80 ? 96 PHE B O 1 ATOM 3733 C CB . PHE B 1 112 ? -0.847 -40.545 21.601 1.00 28.33 ? 96 PHE B CB 1 ATOM 3734 C CG . PHE B 1 112 ? -2.179 -41.207 21.667 1.00 27.44 ? 96 PHE B CG 1 ATOM 3735 C CD1 . PHE B 1 112 ? -3.066 -40.874 22.669 1.00 32.11 ? 96 PHE B CD1 1 ATOM 3736 C CD2 . PHE B 1 112 ? -2.566 -42.125 20.712 1.00 38.48 ? 96 PHE B CD2 1 ATOM 3737 C CE1 . PHE B 1 112 ? -4.309 -41.452 22.735 1.00 35.41 ? 96 PHE B CE1 1 ATOM 3738 C CE2 . PHE B 1 112 ? -3.819 -42.716 20.769 1.00 42.16 ? 96 PHE B CE2 1 ATOM 3739 C CZ . PHE B 1 112 ? -4.689 -42.378 21.785 1.00 38.98 ? 96 PHE B CZ 1 ATOM 3740 N N . VAL B 1 113 ? -0.275 -37.580 22.862 1.00 24.24 ? 97 VAL B N 1 ATOM 3741 C CA . VAL B 1 113 ? 0.610 -36.673 23.576 1.00 25.64 ? 97 VAL B CA 1 ATOM 3742 C C . VAL B 1 113 ? 0.653 -37.055 25.029 1.00 24.39 ? 97 VAL B C 1 ATOM 3743 O O . VAL B 1 113 ? -0.203 -37.790 25.526 1.00 23.12 ? 97 VAL B O 1 ATOM 3744 C CB . VAL B 1 113 ? 0.139 -35.202 23.482 1.00 22.89 ? 97 VAL B CB 1 ATOM 3745 C CG1 . VAL B 1 113 ? 0.503 -34.605 22.139 1.00 23.26 ? 97 VAL B CG1 1 ATOM 3746 C CG2 . VAL B 1 113 ? -1.367 -35.096 23.732 1.00 25.33 ? 97 VAL B CG2 1 ATOM 3747 N N . ASP B 1 114 ? 1.669 -36.551 25.706 1.00 24.32 ? 98 ASP B N 1 ATOM 3748 C CA . ASP B 1 114 ? 1.840 -36.829 27.102 1.00 26.46 ? 98 ASP B CA 1 ATOM 3749 C C . ASP B 1 114 ? 0.938 -35.904 27.870 1.00 27.21 ? 98 ASP B C 1 ATOM 3750 O O . ASP B 1 114 ? 0.979 -34.702 27.671 1.00 28.99 ? 98 ASP B O 1 ATOM 3751 C CB . ASP B 1 114 ? 3.292 -36.606 27.489 1.00 33.35 ? 98 ASP B CB 1 ATOM 3752 C CG . ASP B 1 114 ? 4.201 -37.680 26.944 1.00 38.78 ? 98 ASP B CG 1 ATOM 3753 O OD1 . ASP B 1 114 ? 3.870 -38.873 27.136 1.00 37.93 ? 98 ASP B OD1 1 ATOM 3754 O OD2 . ASP B 1 114 ? 5.230 -37.332 26.312 1.00 41.31 ? 98 ASP B OD2 1 ATOM 3755 N N . ARG B 1 115 ? 0.086 -36.472 28.710 1.00 30.01 ? 99 ARG B N 1 ATOM 3756 C CA . ARG B 1 115 ? -0.618 -35.696 29.719 1.00 30.55 ? 99 ARG B CA 1 ATOM 3757 C C . ARG B 1 115 ? -0.219 -36.346 31.050 1.00 30.02 ? 99 ARG B C 1 ATOM 3758 O O . ARG B 1 115 ? -0.866 -36.152 32.078 1.00 32.41 ? 99 ARG B O 1 ATOM 3759 C CB . ARG B 1 115 ? -2.150 -35.707 29.498 1.00 32.35 ? 99 ARG B CB 1 ATOM 3760 C CG . ARG B 1 115 ? -2.662 -35.584 28.015 1.00 28.35 ? 99 ARG B CG 1 ATOM 3761 C CD . ARG B 1 115 ? -2.468 -34.200 27.347 1.00 26.12 ? 99 ARG B CD 1 ATOM 3762 N NE . ARG B 1 115 ? -3.185 -33.074 27.972 1.00 26.68 ? 99 ARG B NE 1 ATOM 3763 C CZ . ARG B 1 115 ? -4.430 -32.691 27.683 1.00 23.70 ? 99 ARG B CZ 1 ATOM 3764 N NH1 . ARG B 1 115 ? -5.159 -33.350 26.797 1.00 26.29 ? 99 ARG B NH1 1 ATOM 3765 N NH2 . ARG B 1 115 ? -4.967 -31.651 28.298 1.00 27.53 ? 99 ARG B NH2 1 ATOM 3766 N N . GLY B 1 116 ? 0.881 -37.108 30.994 1.00 37.05 ? 100 GLY B N 1 ATOM 3767 C CA . GLY B 1 116 ? 1.377 -37.942 32.085 1.00 39.33 ? 100 GLY B CA 1 ATOM 3768 C C . GLY B 1 116 ? 0.966 -37.607 33.511 1.00 47.15 ? 100 GLY B C 1 ATOM 3769 O O . GLY B 1 116 ? 1.564 -38.125 34.463 1.00 47.15 ? 100 GLY B O 1 ATOM 3770 N N . GLY B 1 118 ? -2.354 -32.718 35.503 1.00 43.45 ? 102 GLY B N 1 ATOM 3771 C CA . GLY B 1 118 ? -1.883 -32.980 34.160 1.00 36.69 ? 102 GLY B CA 1 ATOM 3772 C C . GLY B 1 118 ? -2.466 -31.977 33.186 1.00 40.02 ? 102 GLY B C 1 ATOM 3773 O O . GLY B 1 118 ? -3.343 -32.338 32.402 1.00 42.28 ? 102 GLY B O 1 ATOM 3774 N N . ASN B 1 119 ? -1.988 -30.728 33.249 1.00 47.76 ? 103 ASN B N 1 ATOM 3775 C CA . ASN B 1 119 ? -2.409 -29.643 32.351 1.00 32.56 ? 103 ASN B CA 1 ATOM 3776 C C . ASN B 1 119 ? -3.775 -29.883 31.752 1.00 30.93 ? 103 ASN B C 1 ATOM 3777 O O . ASN B 1 119 ? -3.932 -29.860 30.532 1.00 36.83 ? 103 ASN B O 1 ATOM 3778 C CB . ASN B 1 119 ? -1.374 -29.427 31.230 1.00 37.56 ? 103 ASN B CB 1 ATOM 3779 C CG . ASN B 1 119 ? -1.168 -30.669 30.344 1.00 36.41 ? 103 ASN B CG 1 ATOM 3780 O OD1 . ASN B 1 119 ? -2.128 -31.271 29.863 1.00 41.41 ? 103 ASN B OD1 1 ATOM 3781 N ND2 . ASN B 1 119 ? 0.094 -31.060 30.146 1.00 30.49 ? 103 ASN B ND2 1 ATOM 3782 N N . GLY B 1 120 ? -4.757 -30.129 32.609 1.00 27.89 ? 104 GLY B N 1 ATOM 3783 C CA . GLY B 1 120 ? -6.099 -30.429 32.158 1.00 24.38 ? 104 GLY B CA 1 ATOM 3784 C C . GLY B 1 120 ? -6.546 -31.804 32.598 1.00 26.37 ? 104 GLY B C 1 ATOM 3785 O O . GLY B 1 120 ? -7.736 -32.073 32.708 1.00 33.98 ? 104 GLY B O 1 ATOM 3786 N N . CYS B 1 121 ? -5.585 -32.680 32.857 1.00 29.77 ? 105 CYS B N 1 ATOM 3787 C CA . CYS B 1 121 ? -5.873 -34.075 33.134 1.00 28.09 ? 105 CYS B CA 1 ATOM 3788 C C . CYS B 1 121 ? -5.463 -34.422 34.541 1.00 24.24 ? 105 CYS B C 1 ATOM 3789 O O . CYS B 1 121 ? -4.369 -34.093 34.984 1.00 29.34 ? 105 CYS B O 1 ATOM 3790 C CB . CYS B 1 121 ? -5.149 -34.985 32.148 1.00 28.12 ? 105 CYS B CB 1 ATOM 3791 S SG . CYS B 1 121 ? -5.445 -34.538 30.457 1.00 25.94 ? 105 CYS B SG 1 ATOM 3792 N N . GLY B 1 122 ? -6.361 -35.092 35.239 1.00 25.31 ? 106 GLY B N 1 ATOM 3793 C CA . GLY B 1 122 ? -6.087 -35.572 36.573 1.00 22.51 ? 106 GLY B CA 1 ATOM 3794 C C . GLY B 1 122 ? -5.360 -36.892 36.570 1.00 26.68 ? 106 GLY B C 1 ATOM 3795 O O . GLY B 1 122 ? -4.713 -37.246 37.551 1.00 27.40 ? 106 GLY B O 1 ATOM 3796 N N . LEU B 1 123 ? -5.455 -37.611 35.457 1.00 21.27 ? 107 LEU B N 1 ATOM 3797 C CA . LEU B 1 123 ? -4.797 -38.897 35.326 1.00 21.52 ? 107 LEU B CA 1 ATOM 3798 C C . LEU B 1 123 ? -3.523 -38.761 34.525 1.00 26.50 ? 107 LEU B C 1 ATOM 3799 O O . LEU B 1 123 ? -3.416 -37.909 33.659 1.00 27.34 ? 107 LEU B O 1 ATOM 3800 C CB . LEU B 1 123 ? -5.704 -39.895 34.621 1.00 24.69 ? 107 LEU B CB 1 ATOM 3801 C CG . LEU B 1 123 ? -6.998 -40.264 35.321 1.00 18.70 ? 107 LEU B CG 1 ATOM 3802 C CD1 . LEU B 1 123 ? -7.619 -41.469 34.626 1.00 23.82 ? 107 LEU B CD1 1 ATOM 3803 C CD2 . LEU B 1 123 ? -6.742 -40.521 36.776 1.00 18.88 ? 107 LEU B CD2 1 ATOM 3804 N N . PHE B 1 124 ? -2.579 -39.644 34.804 1.00 26.85 ? 108 PHE B N 1 ATOM 3805 C CA . PHE B 1 124 ? -1.250 -39.560 34.259 1.00 28.41 ? 108 PHE B CA 1 ATOM 3806 C C . PHE B 1 124 ? -1.190 -40.517 33.072 1.00 27.63 ? 108 PHE B C 1 ATOM 3807 O O . PHE B 1 124 ? -1.498 -41.699 33.205 1.00 34.52 ? 108 PHE B O 1 ATOM 3808 C CB . PHE B 1 124 ? -0.260 -39.830 35.423 1.00 35.78 ? 108 PHE B CB 1 ATOM 3809 C CG . PHE B 1 124 ? 0.855 -40.817 35.131 1.00 41.25 ? 108 PHE B CG 1 ATOM 3810 C CD1 . PHE B 1 124 ? 1.658 -40.708 34.006 1.00 38.23 ? 108 PHE B CD1 1 ATOM 3811 C CD2 . PHE B 1 124 ? 1.132 -41.827 36.048 1.00 39.53 ? 108 PHE B CD2 1 ATOM 3812 C CE1 . PHE B 1 124 ? 2.686 -41.606 33.780 1.00 37.23 ? 108 PHE B CE1 1 ATOM 3813 C CE2 . PHE B 1 124 ? 2.161 -42.723 35.831 1.00 38.69 ? 108 PHE B CE2 1 ATOM 3814 C CZ . PHE B 1 124 ? 2.937 -42.615 34.696 1.00 38.11 ? 108 PHE B CZ 1 ATOM 3815 N N . GLY B 1 125 ? -0.899 -39.977 31.889 1.00 23.45 ? 109 GLY B N 1 ATOM 3816 C CA . GLY B 1 125 ? -0.729 -40.786 30.693 1.00 24.15 ? 109 GLY B CA 1 ATOM 3817 C C . GLY B 1 125 ? -0.846 -40.060 29.356 1.00 20.76 ? 109 GLY B C 1 ATOM 3818 O O . GLY B 1 125 ? -0.711 -38.848 29.251 1.00 22.63 ? 109 GLY B O 1 ATOM 3819 N N . LYS B 1 126 ? -1.110 -40.822 28.308 1.00 25.72 ? 110 LYS B N 1 ATOM 3820 C CA . LYS B 1 126 ? -1.117 -40.280 26.953 1.00 24.91 ? 110 LYS B CA 1 ATOM 3821 C C . LYS B 1 126 ? -2.495 -39.870 26.513 1.00 22.64 ? 110 LYS B C 1 ATOM 3822 O O . LYS B 1 126 ? -3.457 -40.592 26.719 1.00 24.51 ? 110 LYS B O 1 ATOM 3823 C CB . LYS B 1 126 ? -0.619 -41.310 25.963 1.00 24.15 ? 110 LYS B CB 1 ATOM 3824 C CG . LYS B 1 126 ? 0.776 -41.078 25.502 1.00 22.41 ? 110 LYS B CG 1 ATOM 3825 C CD . LYS B 1 126 ? 1.759 -41.711 26.426 1.00 24.51 ? 110 LYS B CD 1 ATOM 3826 C CE . LYS B 1 126 ? 3.014 -42.063 25.687 1.00 24.33 ? 110 LYS B CE 1 ATOM 3827 N NZ . LYS B 1 126 ? 3.596 -40.876 25.016 1.00 30.40 ? 110 LYS B NZ 1 ATOM 3828 N N . GLY B 1 127 ? -2.586 -38.713 25.881 1.00 23.73 ? 111 GLY B N 1 ATOM 3829 C CA . GLY B 1 127 ? -3.869 -38.194 25.455 1.00 27.66 ? 111 GLY B CA 1 ATOM 3830 C C . GLY B 1 127 ? -3.985 -38.088 23.943 1.00 28.60 ? 111 GLY B C 1 ATOM 3831 O O . GLY B 1 127 ? -3.021 -37.763 23.256 1.00 25.03 ? 111 GLY B O 1 ATOM 3832 N N . SER B 1 128 ? -5.178 -38.363 23.426 1.00 26.53 ? 112 SER B N 1 ATOM 3833 C CA . SER B 1 128 ? -5.444 -38.233 22.007 1.00 25.26 ? 112 SER B CA 1 ATOM 3834 C C . SER B 1 128 ? -5.400 -36.768 21.581 1.00 23.74 ? 112 SER B C 1 ATOM 3835 O O . SER B 1 128 ? -5.964 -35.914 22.251 1.00 23.88 ? 112 SER B O 1 ATOM 3836 C CB . SER B 1 128 ? -6.809 -38.828 21.698 1.00 27.27 ? 112 SER B CB 1 ATOM 3837 O OG . SER B 1 128 ? -7.136 -38.673 20.333 1.00 31.57 ? 112 SER B OG 1 ATOM 3838 N N . LEU B 1 129 ? -4.718 -36.485 20.473 1.00 20.33 ? 113 LEU B N 1 ATOM 3839 C CA . LEU B 1 129 ? -4.693 -35.148 19.894 1.00 20.95 ? 113 LEU B CA 1 ATOM 3840 C C . LEU B 1 129 ? -4.809 -35.173 18.366 1.00 19.29 ? 113 LEU B C 1 ATOM 3841 O O . LEU B 1 129 ? -4.327 -36.080 17.718 1.00 19.89 ? 113 LEU B O 1 ATOM 3842 C CB . LEU B 1 129 ? -3.419 -34.414 20.298 1.00 21.65 ? 113 LEU B CB 1 ATOM 3843 C CG . LEU B 1 129 ? -3.229 -33.031 19.666 1.00 21.15 ? 113 LEU B CG 1 ATOM 3844 C CD1 . LEU B 1 129 ? -2.572 -32.076 20.627 1.00 25.80 ? 113 LEU B CD1 1 ATOM 3845 C CD2 . LEU B 1 129 ? -2.408 -33.121 18.401 1.00 22.19 ? 113 LEU B CD2 1 ATOM 3846 N N . ILE B 1 130 ? -5.469 -34.169 17.801 1.00 20.28 ? 114 ILE B N 1 ATOM 3847 C CA . ILE B 1 130 ? -5.566 -34.027 16.355 1.00 19.07 ? 114 ILE B CA 1 ATOM 3848 C C . ILE B 1 130 ? -5.440 -32.574 15.949 1.00 17.69 ? 114 ILE B C 1 ATOM 3849 O O . ILE B 1 130 ? -5.856 -31.681 16.662 1.00 20.49 ? 114 ILE B O 1 ATOM 3850 C CB . ILE B 1 130 ? -6.875 -34.645 15.798 1.00 24.68 ? 114 ILE B CB 1 ATOM 3851 C CG1 . ILE B 1 130 ? -6.978 -34.430 14.284 1.00 20.60 ? 114 ILE B CG1 1 ATOM 3852 C CG2 . ILE B 1 130 ? -8.094 -34.073 16.499 1.00 22.59 ? 114 ILE B CG2 1 ATOM 3853 C CD1 . ILE B 1 130 ? -7.942 -35.365 13.625 1.00 21.84 ? 114 ILE B CD1 1 ATOM 3854 N N . THR B 1 131 ? -4.837 -32.347 14.798 1.00 16.26 ? 115 THR B N 1 ATOM 3855 C CA . THR B 1 131 ? -4.599 -31.009 14.295 1.00 18.56 ? 115 THR B CA 1 ATOM 3856 C C . THR B 1 131 ? -5.042 -30.971 12.846 1.00 21.74 ? 115 THR B C 1 ATOM 3857 O O . THR B 1 131 ? -4.837 -31.942 12.113 1.00 21.00 ? 115 THR B O 1 ATOM 3858 C CB . THR B 1 131 ? -3.113 -30.653 14.359 1.00 19.67 ? 115 THR B CB 1 ATOM 3859 O OG1 . THR B 1 131 ? -2.646 -30.811 15.699 1.00 23.14 ? 115 THR B OG1 1 ATOM 3860 C CG2 . THR B 1 131 ? -2.874 -29.223 13.914 1.00 19.84 ? 115 THR B CG2 1 ATOM 3861 N N . CYS B 1 132 ? -5.677 -29.866 12.455 1.00 21.64 ? 116 CYS B N 1 ATOM 3862 C CA . CYS B 1 132 ? -6.146 -29.661 11.087 1.00 21.66 ? 116 CYS B CA 1 ATOM 3863 C C . CYS B 1 132 ? -5.753 -28.274 10.656 1.00 24.13 ? 116 CYS B C 1 ATOM 3864 O O . CYS B 1 132 ? -5.726 -27.361 11.473 1.00 25.83 ? 116 CYS B O 1 ATOM 3865 C CB . CYS B 1 132 ? -7.661 -29.778 11.001 1.00 22.11 ? 116 CYS B CB 1 ATOM 3866 S SG . CYS B 1 132 ? -8.264 -31.418 11.181 1.00 24.60 ? 116 CYS B SG 1 ATOM 3867 N N . ALA B 1 133 ? -5.469 -28.110 9.370 1.00 24.03 ? 117 ALA B N 1 ATOM 3868 C CA . ALA B 1 133 ? -4.998 -26.834 8.849 1.00 24.24 ? 117 ALA B CA 1 ATOM 3869 C C . ALA B 1 133 ? -5.472 -26.655 7.425 1.00 23.09 ? 117 ALA B C 1 ATOM 3870 O O . ALA B 1 133 ? -5.534 -27.610 6.683 1.00 24.74 ? 117 ALA B O 1 ATOM 3871 C CB . ALA B 1 133 ? -3.490 -26.783 8.900 1.00 28.77 ? 117 ALA B CB 1 ATOM 3872 N N . LYS B 1 134 ? -5.803 -25.430 7.042 1.00 25.05 ? 118 LYS B N 1 ATOM 3873 C CA . LYS B 1 134 ? -6.328 -25.183 5.712 1.00 25.89 ? 118 LYS B CA 1 ATOM 3874 C C . LYS B 1 134 ? -5.212 -25.183 4.680 1.00 26.55 ? 118 LYS B C 1 ATOM 3875 O O . LYS B 1 134 ? -4.412 -24.263 4.632 1.00 24.62 ? 118 LYS B O 1 ATOM 3876 C CB . LYS B 1 134 ? -7.092 -23.857 5.671 1.00 26.05 ? 118 LYS B CB 1 ATOM 3877 C CG . LYS B 1 134 ? -7.553 -23.482 4.281 1.00 28.44 ? 118 LYS B CG 1 ATOM 3878 C CD . LYS B 1 134 ? -8.719 -22.504 4.261 1.00 38.26 ? 118 LYS B CD 1 ATOM 3879 C CE . LYS B 1 134 ? -8.500 -21.315 5.197 1.00 48.29 ? 118 LYS B CE 1 ATOM 3880 N NZ . LYS B 1 134 ? -9.377 -20.114 4.914 1.00 49.56 ? 118 LYS B NZ 1 ATOM 3881 N N . PHE B 1 135 ? -5.174 -26.238 3.869 1.00 29.48 ? 119 PHE B N 1 ATOM 3882 C CA . PHE B 1 135 ? -4.282 -26.348 2.720 1.00 24.50 ? 119 PHE B CA 1 ATOM 3883 C C . PHE B 1 135 ? -4.843 -25.560 1.541 1.00 22.86 ? 119 PHE B C 1 ATOM 3884 O O . PHE B 1 135 ? -5.957 -25.817 1.101 1.00 22.22 ? 119 PHE B O 1 ATOM 3885 C CB . PHE B 1 135 ? -4.144 -27.825 2.321 1.00 24.43 ? 119 PHE B CB 1 ATOM 3886 C CG . PHE B 1 135 ? -3.190 -28.076 1.168 1.00 22.89 ? 119 PHE B CG 1 ATOM 3887 C CD1 . PHE B 1 135 ? -1.847 -28.252 1.393 1.00 20.73 ? 119 PHE B CD1 1 ATOM 3888 C CD2 . PHE B 1 135 ? -3.646 -28.157 -0.132 1.00 16.74 ? 119 PHE B CD2 1 ATOM 3889 C CE1 . PHE B 1 135 ? -0.989 -28.486 0.347 1.00 19.32 ? 119 PHE B CE1 1 ATOM 3890 C CE2 . PHE B 1 135 ? -2.785 -28.390 -1.162 1.00 15.02 ? 119 PHE B CE2 1 ATOM 3891 C CZ . PHE B 1 135 ? -1.466 -28.553 -0.924 1.00 18.29 ? 119 PHE B CZ 1 ATOM 3892 N N . LYS B 1 136 ? -4.060 -24.616 1.026 1.00 24.23 ? 120 LYS B N 1 ATOM 3893 C CA . LYS B 1 136 ? -4.460 -23.827 -0.131 1.00 23.48 ? 120 LYS B CA 1 ATOM 3894 C C . LYS B 1 136 ? -3.355 -23.776 -1.166 1.00 24.90 ? 120 LYS B C 1 ATOM 3895 O O . LYS B 1 136 ? -2.245 -23.354 -0.874 1.00 27.42 ? 120 LYS B O 1 ATOM 3896 C CB . LYS B 1 136 ? -4.787 -22.406 0.293 1.00 19.72 ? 120 LYS B CB 1 ATOM 3897 C CG . LYS B 1 136 ? -4.993 -21.485 -0.861 1.00 22.56 ? 120 LYS B CG 1 ATOM 3898 C CD . LYS B 1 136 ? -6.041 -22.026 -1.794 1.00 27.42 ? 120 LYS B CD 1 ATOM 3899 C CE . LYS B 1 136 ? -6.311 -21.091 -2.955 1.00 29.63 ? 120 LYS B CE 1 ATOM 3900 N NZ . LYS B 1 136 ? -6.953 -19.805 -2.537 1.00 31.18 ? 120 LYS B NZ 1 ATOM 3901 N N . CYS B 1 137 ? -3.640 -24.194 -2.387 1.00 25.44 ? 121 CYS B N 1 ATOM 3902 C CA . CYS B 1 137 ? -2.623 -24.077 -3.416 1.00 25.95 ? 121 CYS B CA 1 ATOM 3903 C C . CYS B 1 137 ? -2.570 -22.660 -3.991 1.00 24.79 ? 121 CYS B C 1 ATOM 3904 O O . CYS B 1 137 ? -3.504 -22.199 -4.646 1.00 25.85 ? 121 CYS B O 1 ATOM 3905 C CB . CYS B 1 137 ? -2.829 -25.093 -4.535 1.00 26.55 ? 121 CYS B CB 1 ATOM 3906 S SG . CYS B 1 137 ? -1.315 -25.362 -5.489 1.00 26.56 ? 121 CYS B SG 1 ATOM 3907 N N . VAL B 1 138 ? -1.461 -21.978 -3.733 1.00 26.14 ? 122 VAL B N 1 ATOM 3908 C CA . VAL B 1 138 ? -1.253 -20.639 -4.251 1.00 28.70 ? 122 VAL B CA 1 ATOM 3909 C C . VAL B 1 138 ? -0.974 -20.745 -5.752 1.00 29.97 ? 122 VAL B C 1 ATOM 3910 O O . VAL B 1 138 ? -1.527 -19.999 -6.557 1.00 32.01 ? 122 VAL B O 1 ATOM 3911 C CB . VAL B 1 138 ? -0.052 -19.945 -3.564 1.00 29.42 ? 122 VAL B CB 1 ATOM 3912 C CG1 . VAL B 1 138 ? 0.040 -18.467 -3.973 1.00 32.42 ? 122 VAL B CG1 1 ATOM 3913 C CG2 . VAL B 1 138 ? -0.143 -20.068 -2.068 1.00 27.43 ? 122 VAL B CG2 1 ATOM 3914 N N . THR B 1 139 ? -0.124 -21.697 -6.121 1.00 27.77 ? 123 THR B N 1 ATOM 3915 C CA . THR B 1 139 ? 0.394 -21.784 -7.485 1.00 31.23 ? 123 THR B CA 1 ATOM 3916 C C . THR B 1 139 ? 0.487 -23.216 -7.981 1.00 26.73 ? 123 THR B C 1 ATOM 3917 O O . THR B 1 139 ? 1.143 -24.053 -7.359 1.00 22.02 ? 123 THR B O 1 ATOM 3918 C CB . THR B 1 139 ? 1.792 -21.188 -7.577 1.00 32.24 ? 123 THR B CB 1 ATOM 3919 O OG1 . THR B 1 139 ? 1.764 -19.851 -7.060 1.00 44.09 ? 123 THR B OG1 1 ATOM 3920 C CG2 . THR B 1 139 ? 2.275 -21.181 -9.028 1.00 28.67 ? 123 THR B CG2 1 ATOM 3921 N N . LYS B 1 140 ? -0.145 -23.482 -9.118 1.00 24.94 ? 124 LYS B N 1 ATOM 3922 C CA . LYS B 1 140 ? -0.212 -24.832 -9.638 1.00 19.49 ? 124 LYS B CA 1 ATOM 3923 C C . LYS B 1 140 ? 0.497 -24.957 -10.993 1.00 18.80 ? 124 LYS B C 1 ATOM 3924 O O . LYS B 1 140 ? 0.705 -23.966 -11.691 1.00 22.16 ? 124 LYS B O 1 ATOM 3925 C CB . LYS B 1 140 ? -1.675 -25.294 -9.736 1.00 21.60 ? 124 LYS B CB 1 ATOM 3926 C CG . LYS B 1 140 ? -2.741 -24.182 -9.849 1.00 34.15 ? 124 LYS B CG 1 ATOM 3927 C CD . LYS B 1 140 ? -3.459 -23.897 -8.514 1.00 31.54 ? 124 LYS B CD 1 ATOM 3928 C CE . LYS B 1 140 ? -4.137 -22.518 -8.510 1.00 34.61 ? 124 LYS B CE 1 ATOM 3929 N NZ . LYS B 1 140 ? -4.624 -22.102 -7.162 1.00 32.81 ? 124 LYS B NZ 1 ATOM 3930 N N . LEU B 1 141 ? 0.901 -26.175 -11.341 1.00 15.70 ? 125 LEU B N 1 ATOM 3931 C CA . LEU B 1 141 ? 1.236 -26.488 -12.732 1.00 19.19 ? 125 LEU B CA 1 ATOM 3932 C C . LEU B 1 141 ? 0.262 -27.540 -13.282 1.00 14.97 ? 125 LEU B C 1 ATOM 3933 O O . LEU B 1 141 ? -0.277 -28.336 -12.525 1.00 15.88 ? 125 LEU B O 1 ATOM 3934 C CB . LEU B 1 141 ? 2.696 -26.920 -12.873 1.00 16.41 ? 125 LEU B CB 1 ATOM 3935 C CG . LEU B 1 141 ? 3.165 -28.301 -12.447 1.00 17.22 ? 125 LEU B CG 1 ATOM 3936 C CD1 . LEU B 1 141 ? 2.635 -29.374 -13.374 1.00 15.00 ? 125 LEU B CD1 1 ATOM 3937 C CD2 . LEU B 1 141 ? 4.684 -28.322 -12.446 1.00 16.90 ? 125 LEU B CD2 1 ATOM 3938 N N . GLU B 1 142 ? 0.020 -27.512 -14.591 1.00 16.59 ? 126 GLU B N 1 ATOM 3939 C CA . GLU B 1 142 ? -0.876 -28.458 -15.261 1.00 15.09 ? 126 GLU B CA 1 ATOM 3940 C C . GLU B 1 142 ? -0.159 -29.271 -16.329 1.00 9.12 ? 126 GLU B C 1 ATOM 3941 O O . GLU B 1 142 ? 0.630 -28.734 -17.089 1.00 9.45 ? 126 GLU B O 1 ATOM 3942 C CB . GLU B 1 142 ? -2.029 -27.708 -15.918 1.00 15.77 ? 126 GLU B CB 1 ATOM 3943 C CG . GLU B 1 142 ? -3.025 -27.123 -14.939 1.00 19.31 ? 126 GLU B CG 1 ATOM 3944 C CD . GLU B 1 142 ? -4.013 -26.191 -15.589 1.00 22.88 ? 126 GLU B CD 1 ATOM 3945 O OE1 . GLU B 1 142 ? -3.959 -26.024 -16.824 1.00 26.94 ? 126 GLU B OE1 1 ATOM 3946 O OE2 . GLU B 1 142 ? -4.847 -25.612 -14.861 1.00 37.40 ? 126 GLU B OE2 1 ATOM 3947 N N . GLY B 1 143 ? -0.420 -30.572 -16.368 1.00 7.39 ? 127 GLY B N 1 ATOM 3948 C CA . GLY B 1 143 ? 0.054 -31.417 -17.453 1.00 8.27 ? 127 GLY B CA 1 ATOM 3949 C C . GLY B 1 143 ? -1.116 -31.737 -18.359 1.00 6.63 ? 127 GLY B C 1 ATOM 3950 O O . GLY B 1 143 ? -2.137 -32.167 -17.877 1.00 8.25 ? 127 GLY B O 1 ATOM 3951 N N . LYS B 1 144 ? -0.969 -31.538 -19.659 1.00 6.39 ? 128 LYS B N 1 ATOM 3952 C CA . LYS B 1 144 ? -2.086 -31.654 -20.577 1.00 7.76 ? 128 LYS B CA 1 ATOM 3953 C C . LYS B 1 144 ? -1.802 -32.681 -21.672 1.00 9.08 ? 128 LYS B C 1 ATOM 3954 O O . LYS B 1 144 ? -0.679 -32.786 -22.169 1.00 8.84 ? 128 LYS B O 1 ATOM 3955 C CB . LYS B 1 144 ? -2.377 -30.289 -21.194 1.00 7.51 ? 128 LYS B CB 1 ATOM 3956 C CG . LYS B 1 144 ? -2.887 -29.250 -20.194 1.00 10.85 ? 128 LYS B CG 1 ATOM 3957 C CD . LYS B 1 144 ? -2.920 -27.842 -20.791 1.00 14.90 ? 128 LYS B CD 1 ATOM 3958 C CE . LYS B 1 144 ? -3.693 -26.847 -19.899 1.00 18.89 ? 128 LYS B CE 1 ATOM 3959 N NZ . LYS B 1 144 ? -4.564 -25.890 -20.667 1.00 21.70 ? 128 LYS B NZ 1 ATOM 3960 N N . ILE B 1 145 ? -2.808 -33.464 -22.038 1.00 8.39 ? 129 ILE B N 1 ATOM 3961 C CA . ILE B 1 145 ? -2.599 -34.413 -23.104 1.00 7.99 ? 129 ILE B CA 1 ATOM 3962 C C . ILE B 1 145 ? -3.116 -33.879 -24.420 1.00 8.02 ? 129 ILE B C 1 ATOM 3963 O O . ILE B 1 145 ? -4.140 -33.200 -24.486 1.00 8.33 ? 129 ILE B O 1 ATOM 3964 C CB . ILE B 1 145 ? -3.220 -35.768 -22.819 1.00 12.27 ? 129 ILE B CB 1 ATOM 3965 C CG1 . ILE B 1 145 ? -4.652 -35.615 -22.325 1.00 7.66 ? 129 ILE B CG1 1 ATOM 3966 C CG2 . ILE B 1 145 ? -2.369 -36.495 -21.814 1.00 11.46 ? 129 ILE B CG2 1 ATOM 3967 C CD1 . ILE B 1 145 ? -5.534 -36.735 -22.790 1.00 12.97 ? 129 ILE B CD1 1 ATOM 3968 N N . VAL B 1 146 ? -2.368 -34.192 -25.471 1.00 7.42 ? 130 VAL B N 1 ATOM 3969 C CA . VAL B 1 146 ? -2.718 -33.820 -26.823 1.00 8.18 ? 130 VAL B CA 1 ATOM 3970 C C . VAL B 1 146 ? -3.312 -35.012 -27.531 1.00 7.46 ? 130 VAL B C 1 ATOM 3971 O O . VAL B 1 146 ? -2.657 -36.015 -27.744 1.00 6.90 ? 130 VAL B O 1 ATOM 3972 C CB . VAL B 1 146 ? -1.505 -33.329 -27.612 1.00 7.30 ? 130 VAL B CB 1 ATOM 3973 C CG1 . VAL B 1 146 ? -1.926 -32.861 -28.982 1.00 6.77 ? 130 VAL B CG1 1 ATOM 3974 C CG2 . VAL B 1 146 ? -0.824 -32.202 -26.842 1.00 11.68 ? 130 VAL B CG2 1 ATOM 3975 N N . GLN B 1 147 ? -4.581 -34.877 -27.875 1.00 6.64 ? 131 GLN B N 1 ATOM 3976 C CA . GLN B 1 147 ? -5.317 -35.890 -28.589 1.00 7.41 ? 131 GLN B CA 1 ATOM 3977 C C . GLN B 1 147 ? -5.491 -35.488 -30.060 1.00 5.97 ? 131 GLN B C 1 ATOM 3978 O O . GLN B 1 147 ? -5.148 -34.377 -30.435 1.00 6.35 ? 131 GLN B O 1 ATOM 3979 C CB . GLN B 1 147 ? -6.679 -36.048 -27.935 1.00 5.05 ? 131 GLN B CB 1 ATOM 3980 C CG . GLN B 1 147 ? -6.609 -36.477 -26.481 1.00 6.24 ? 131 GLN B CG 1 ATOM 3981 C CD . GLN B 1 147 ? -7.956 -36.488 -25.836 1.00 8.10 ? 131 GLN B CD 1 ATOM 3982 O OE1 . GLN B 1 147 ? -8.321 -35.564 -25.104 1.00 10.75 ? 131 GLN B OE1 1 ATOM 3983 N NE2 . GLN B 1 147 ? -8.724 -37.527 -26.118 1.00 6.63 ? 131 GLN B NE2 1 ATOM 3984 N N . TYR B 1 148 ? -6.009 -36.397 -30.886 1.00 7.12 ? 132 TYR B N 1 ATOM 3985 C CA . TYR B 1 148 ? -6.240 -36.104 -32.301 1.00 7.50 ? 132 TYR B CA 1 ATOM 3986 C C . TYR B 1 148 ? -7.066 -34.844 -32.466 1.00 7.56 ? 132 TYR B C 1 ATOM 3987 O O . TYR B 1 148 ? -6.829 -34.052 -33.358 1.00 6.98 ? 132 TYR B O 1 ATOM 3988 C CB . TYR B 1 148 ? -6.997 -37.239 -32.987 1.00 7.21 ? 132 TYR B CB 1 ATOM 3989 C CG . TYR B 1 148 ? -6.222 -38.507 -33.175 1.00 9.42 ? 132 TYR B CG 1 ATOM 3990 C CD1 . TYR B 1 148 ? -4.884 -38.487 -33.529 1.00 12.73 ? 132 TYR B CD1 1 ATOM 3991 C CD2 . TYR B 1 148 ? -6.828 -39.730 -33.005 1.00 9.95 ? 132 TYR B CD2 1 ATOM 3992 C CE1 . TYR B 1 148 ? -4.165 -39.667 -33.694 1.00 16.03 ? 132 TYR B CE1 1 ATOM 3993 C CE2 . TYR B 1 148 ? -6.121 -40.910 -33.150 1.00 12.48 ? 132 TYR B CE2 1 ATOM 3994 C CZ . TYR B 1 148 ? -4.801 -40.871 -33.501 1.00 13.42 ? 132 TYR B CZ 1 ATOM 3995 O OH . TYR B 1 148 ? -4.130 -42.050 -33.648 1.00 17.13 ? 132 TYR B OH 1 ATOM 3996 N N . GLU B 1 149 ? -8.064 -34.675 -31.611 1.00 8.32 ? 133 GLU B N 1 ATOM 3997 C CA . GLU B 1 149 ? -9.001 -33.573 -31.744 1.00 7.38 ? 133 GLU B CA 1 ATOM 3998 C C . GLU B 1 149 ? -8.383 -32.193 -31.466 1.00 7.97 ? 133 GLU B C 1 ATOM 3999 O O . GLU B 1 149 ? -9.044 -31.184 -31.651 1.00 8.39 ? 133 GLU B O 1 ATOM 4000 C CB . GLU B 1 149 ? -10.180 -33.797 -30.797 1.00 8.83 ? 133 GLU B CB 1 ATOM 4001 C CG . GLU B 1 149 ? -9.824 -33.568 -29.327 1.00 8.13 ? 133 GLU B CG 1 ATOM 4002 C CD . GLU B 1 149 ? -10.808 -34.205 -28.367 1.00 10.55 ? 133 GLU B CD 1 ATOM 4003 O OE1 . GLU B 1 149 ? -11.001 -35.432 -28.444 1.00 15.24 ? 133 GLU B OE1 1 ATOM 4004 O OE2 . GLU B 1 149 ? -11.400 -33.487 -27.532 1.00 11.94 ? 133 GLU B OE2 1 ATOM 4005 N N . ASN B 1 150 ? -7.131 -32.142 -31.026 1.00 7.16 ? 134 ASN B N 1 ATOM 4006 C CA . ASN B 1 150 ? -6.513 -30.877 -30.634 1.00 7.69 ? 134 ASN B CA 1 ATOM 4007 C C . ASN B 1 150 ? -5.498 -30.351 -31.626 1.00 8.40 ? 134 ASN B C 1 ATOM 4008 O O . ASN B 1 150 ? -4.991 -29.270 -31.436 1.00 8.94 ? 134 ASN B O 1 ATOM 4009 C CB . ASN B 1 150 ? -5.799 -31.020 -29.291 1.00 6.81 ? 134 ASN B CB 1 ATOM 4010 C CG . ASN B 1 150 ? -6.698 -31.526 -28.209 1.00 6.72 ? 134 ASN B CG 1 ATOM 4011 O OD1 . ASN B 1 150 ? -6.512 -32.614 -27.687 1.00 6.82 ? 134 ASN B OD1 1 ATOM 4012 N ND2 . ASN B 1 150 ? -7.678 -30.727 -27.852 1.00 7.82 ? 134 ASN B ND2 1 ATOM 4013 N N . LEU B 1 151 ? -5.192 -31.129 -32.658 1.00 8.69 ? 135 LEU B N 1 ATOM 4014 C CA . LEU B 1 151 ? -4.110 -30.844 -33.589 1.00 7.02 ? 135 LEU B CA 1 ATOM 4015 C C . LEU B 1 151 ? -4.694 -30.432 -34.916 1.00 9.89 ? 135 LEU B C 1 ATOM 4016 O O . LEU B 1 151 ? -5.566 -31.115 -35.435 1.00 9.21 ? 135 LEU B O 1 ATOM 4017 C CB . LEU B 1 151 ? -3.304 -32.121 -33.815 1.00 9.03 ? 135 LEU B CB 1 ATOM 4018 C CG . LEU B 1 151 ? -1.800 -32.060 -34.106 1.00 12.90 ? 135 LEU B CG 1 ATOM 4019 C CD1 . LEU B 1 151 ? -1.427 -33.215 -34.989 1.00 10.62 ? 135 LEU B CD1 1 ATOM 4020 C CD2 . LEU B 1 151 ? -1.336 -30.767 -34.722 1.00 8.26 ? 135 LEU B CD2 1 ATOM 4021 N N . LYS B 1 152 ? -4.215 -29.327 -35.479 1.00 9.32 ? 136 LYS B N 1 ATOM 4022 C CA . LYS B 1 152 ? -4.655 -28.905 -36.798 1.00 8.18 ? 136 LYS B CA 1 ATOM 4023 C C . LYS B 1 152 ? -3.581 -28.159 -37.565 1.00 8.28 ? 136 LYS B C 1 ATOM 4024 O O . LYS B 1 152 ? -2.741 -27.499 -36.994 1.00 8.03 ? 136 LYS B O 1 ATOM 4025 C CB . LYS B 1 152 ? -5.894 -28.014 -36.711 1.00 9.22 ? 136 LYS B CB 1 ATOM 4026 C CG . LYS B 1 152 ? -5.590 -26.550 -36.869 1.00 14.67 ? 136 LYS B CG 1 ATOM 4027 C CD . LYS B 1 152 ? -6.763 -25.708 -36.455 1.00 15.67 ? 136 LYS B CD 1 ATOM 4028 C CE . LYS B 1 152 ? -6.448 -24.239 -36.549 1.00 20.41 ? 136 LYS B CE 1 ATOM 4029 N NZ . LYS B 1 152 ? -6.930 -23.513 -35.343 1.00 18.79 ? 136 LYS B NZ 1 ATOM 4030 N N . TYR B 1 153 ? -3.654 -28.273 -38.884 1.00 9.17 ? 137 TYR B N 1 ATOM 4031 C CA . TYR B 1 153 ? -2.708 -27.656 -39.792 1.00 7.38 ? 137 TYR B CA 1 ATOM 4032 C C . TYR B 1 153 ? -3.421 -26.804 -40.814 1.00 8.16 ? 137 TYR B C 1 ATOM 4033 O O . TYR B 1 153 ? -4.476 -27.176 -41.313 1.00 9.24 ? 137 TYR B O 1 ATOM 4034 C CB . TYR B 1 153 ? -1.979 -28.723 -40.567 1.00 8.40 ? 137 TYR B CB 1 ATOM 4035 C CG . TYR B 1 153 ? -1.212 -29.715 -39.740 1.00 10.69 ? 137 TYR B CG 1 ATOM 4036 C CD1 . TYR B 1 153 ? -1.858 -30.760 -39.082 1.00 8.80 ? 137 TYR B CD1 1 ATOM 4037 C CD2 . TYR B 1 153 ? 0.167 -29.632 -39.656 1.00 8.96 ? 137 TYR B CD2 1 ATOM 4038 C CE1 . TYR B 1 153 ? -1.145 -31.676 -38.354 1.00 9.95 ? 137 TYR B CE1 1 ATOM 4039 C CE2 . TYR B 1 153 ? 0.887 -30.538 -38.944 1.00 9.27 ? 137 TYR B CE2 1 ATOM 4040 C CZ . TYR B 1 153 ? 0.237 -31.561 -38.294 1.00 11.86 ? 137 TYR B CZ 1 ATOM 4041 O OH . TYR B 1 153 ? 0.998 -32.460 -37.590 1.00 13.98 ? 137 TYR B OH 1 ATOM 4042 N N . SER B 1 154 ? -2.820 -25.674 -41.153 1.00 10.03 ? 138 SER B N 1 ATOM 4043 C CA . SER B 1 154 ? -3.351 -24.812 -42.199 1.00 11.52 ? 138 SER B CA 1 ATOM 4044 C C . SER B 1 154 ? -2.387 -24.828 -43.372 1.00 8.86 ? 138 SER B C 1 ATOM 4045 O O . SER B 1 154 ? -1.203 -24.526 -43.218 1.00 7.56 ? 138 SER B O 1 ATOM 4046 C CB . SER B 1 154 ? -3.548 -23.392 -41.693 1.00 8.45 ? 138 SER B CB 1 ATOM 4047 O OG . SER B 1 154 ? -4.466 -23.367 -40.623 1.00 14.45 ? 138 SER B OG 1 ATOM 4048 N N . VAL B 1 155 ? -2.914 -25.211 -44.528 1.00 8.20 ? 139 VAL B N 1 ATOM 4049 C CA . VAL B 1 155 ? -2.130 -25.399 -45.734 1.00 7.94 ? 139 VAL B CA 1 ATOM 4050 C C . VAL B 1 155 ? -2.655 -24.481 -46.832 1.00 9.03 ? 139 VAL B C 1 ATOM 4051 O O . VAL B 1 155 ? -3.837 -24.496 -47.157 1.00 9.95 ? 139 VAL B O 1 ATOM 4052 C CB . VAL B 1 155 ? -2.223 -26.866 -46.182 1.00 6.51 ? 139 VAL B CB 1 ATOM 4053 C CG1 . VAL B 1 155 ? -1.479 -27.088 -47.492 1.00 7.33 ? 139 VAL B CG1 1 ATOM 4054 C CG2 . VAL B 1 155 ? -1.709 -27.775 -45.068 1.00 5.48 ? 139 VAL B CG2 1 ATOM 4055 N N . ILE B 1 156 ? -1.790 -23.675 -47.416 1.00 8.42 ? 140 ILE B N 1 ATOM 4056 C CA . ILE B 1 156 ? -2.283 -22.768 -48.443 1.00 11.19 ? 140 ILE B CA 1 ATOM 4057 C C . ILE B 1 156 ? -1.922 -23.269 -49.835 1.00 9.08 ? 140 ILE B C 1 ATOM 4058 O O . ILE B 1 156 ? -0.814 -23.736 -50.070 1.00 9.03 ? 140 ILE B O 1 ATOM 4059 C CB . ILE B 1 156 ? -1.819 -21.315 -48.211 1.00 8.58 ? 140 ILE B CB 1 ATOM 4060 C CG1 . ILE B 1 156 ? -2.451 -20.393 -49.243 1.00 9.93 ? 140 ILE B CG1 1 ATOM 4061 C CG2 . ILE B 1 156 ? -0.334 -21.209 -48.316 1.00 13.58 ? 140 ILE B CG2 1 ATOM 4062 C CD1 . ILE B 1 156 ? -2.346 -18.924 -48.902 1.00 9.85 ? 140 ILE B CD1 1 ATOM 4063 N N . VAL B 1 157 ? -2.903 -23.220 -50.727 1.00 10.45 ? 141 VAL B N 1 ATOM 4064 C CA . VAL B 1 157 ? -2.719 -23.622 -52.108 1.00 13.65 ? 141 VAL B CA 1 ATOM 4065 C C . VAL B 1 157 ? -3.029 -22.468 -53.036 1.00 12.36 ? 141 VAL B C 1 ATOM 4066 O O . VAL B 1 157 ? -4.101 -21.897 -52.975 1.00 13.21 ? 141 VAL B O 1 ATOM 4067 C CB . VAL B 1 157 ? -3.617 -24.794 -52.479 1.00 12.75 ? 141 VAL B CB 1 ATOM 4068 C CG1 . VAL B 1 157 ? -3.290 -25.271 -53.901 1.00 12.40 ? 141 VAL B CG1 1 ATOM 4069 C CG2 . VAL B 1 157 ? -3.476 -25.927 -51.455 1.00 14.36 ? 141 VAL B CG2 1 ATOM 4070 N N . THR B 1 158 ? -2.073 -22.142 -53.899 1.00 14.23 ? 142 THR B N 1 ATOM 4071 C CA . THR B 1 158 ? -2.144 -20.968 -54.767 1.00 16.86 ? 142 THR B CA 1 ATOM 4072 C C . THR B 1 158 ? -1.874 -21.318 -56.216 1.00 13.34 ? 142 THR B C 1 ATOM 4073 O O . THR B 1 158 ? -0.875 -21.917 -56.526 1.00 16.69 ? 142 THR B O 1 ATOM 4074 C CB . THR B 1 158 ? -1.090 -19.927 -54.358 1.00 19.50 ? 142 THR B CB 1 ATOM 4075 O OG1 . THR B 1 158 ? -1.199 -19.670 -52.952 1.00 19.10 ? 142 THR B OG1 1 ATOM 4076 C CG2 . THR B 1 158 ? -1.261 -18.617 -55.151 1.00 19.96 ? 142 THR B CG2 1 ATOM 4077 N N . VAL B 1 159 ? -2.782 -20.943 -57.097 1.00 16.74 ? 143 VAL B N 1 ATOM 4078 C CA . VAL B 1 159 ? -2.561 -21.055 -58.521 1.00 20.15 ? 143 VAL B CA 1 ATOM 4079 C C . VAL B 1 159 ? -2.293 -19.645 -59.005 1.00 21.38 ? 143 VAL B C 1 ATOM 4080 O O . VAL B 1 159 ? -3.069 -18.725 -58.755 1.00 22.91 ? 143 VAL B O 1 ATOM 4081 C CB . VAL B 1 159 ? -3.785 -21.655 -59.246 1.00 21.43 ? 143 VAL B CB 1 ATOM 4082 C CG1 . VAL B 1 159 ? -3.512 -21.812 -60.730 1.00 26.25 ? 143 VAL B CG1 1 ATOM 4083 C CG2 . VAL B 1 159 ? -4.135 -22.997 -58.660 1.00 18.14 ? 143 VAL B CG2 1 ATOM 4084 N N . HIS B 1 160 ? -1.161 -19.480 -59.664 1.00 21.23 ? 144 HIS B N 1 ATOM 4085 C CA . HIS B 1 160 ? -0.660 -18.168 -60.019 1.00 24.11 ? 144 HIS B CA 1 ATOM 4086 C C . HIS B 1 160 ? -1.187 -17.672 -61.346 1.00 30.31 ? 144 HIS B C 1 ATOM 4087 O O . HIS B 1 160 ? -0.572 -17.909 -62.377 1.00 24.82 ? 144 HIS B O 1 ATOM 4088 C CB . HIS B 1 160 ? 0.852 -18.228 -60.124 1.00 28.21 ? 144 HIS B CB 1 ATOM 4089 C CG . HIS B 1 160 ? 1.531 -18.321 -58.817 1.00 23.51 ? 144 HIS B CG 1 ATOM 4090 N ND1 . HIS B 1 160 ? 1.911 -17.217 -58.085 1.00 27.81 ? 144 HIS B ND1 1 ATOM 4091 C CD2 . HIS B 1 160 ? 1.911 -19.408 -58.074 1.00 20.16 ? 144 HIS B CD2 1 ATOM 4092 C CE1 . HIS B 1 160 ? 2.483 -17.610 -56.967 1.00 28.85 ? 144 HIS B CE1 1 ATOM 4093 N NE2 . HIS B 1 160 ? 2.496 -18.913 -56.939 1.00 22.89 ? 144 HIS B NE2 1 ATOM 4094 N N . THR B 1 161 ? -2.297 -16.951 -61.318 1.00 39.29 ? 145 THR B N 1 ATOM 4095 C CA . THR B 1 161 ? -2.900 -16.444 -62.542 1.00 45.92 ? 145 THR B CA 1 ATOM 4096 C C . THR B 1 161 ? -2.134 -15.227 -63.061 1.00 54.52 ? 145 THR B C 1 ATOM 4097 O O . THR B 1 161 ? -1.618 -15.232 -64.180 1.00 65.88 ? 145 THR B O 1 ATOM 4098 C CB . THR B 1 161 ? -4.363 -16.059 -62.309 1.00 49.62 ? 145 THR B CB 1 ATOM 4099 O OG1 . THR B 1 161 ? -5.087 -17.204 -61.844 1.00 42.94 ? 145 THR B OG1 1 ATOM 4100 C CG2 . THR B 1 161 ? -4.993 -15.534 -63.599 1.00 61.46 ? 145 THR B CG2 1 ATOM 4101 N N . HIS B 1 174 ? -4.811 -14.865 -53.996 1.00 42.02 ? 158 HIS B N 1 ATOM 4102 C CA . HIS B 1 174 ? -5.911 -15.704 -53.532 1.00 46.38 ? 158 HIS B CA 1 ATOM 4103 C C . HIS B 1 174 ? -5.493 -17.171 -53.468 1.00 37.20 ? 158 HIS B C 1 ATOM 4104 O O . HIS B 1 174 ? -5.865 -17.984 -54.314 1.00 37.23 ? 158 HIS B O 1 ATOM 4105 C CB . HIS B 1 174 ? -7.138 -15.537 -54.436 1.00 51.55 ? 158 HIS B CB 1 ATOM 4106 C CG . HIS B 1 174 ? -6.815 -15.543 -55.893 1.00 56.34 ? 158 HIS B CG 1 ATOM 4107 N ND1 . HIS B 1 174 ? -6.764 -16.697 -56.648 1.00 53.27 ? 158 HIS B ND1 1 ATOM 4108 C CD2 . HIS B 1 174 ? -6.509 -14.526 -56.744 1.00 56.27 ? 158 HIS B CD2 1 ATOM 4109 C CE1 . HIS B 1 174 ? -6.445 -16.393 -57.892 1.00 59.40 ? 158 HIS B CE1 1 ATOM 4110 N NE2 . HIS B 1 174 ? -6.286 -15.087 -57.975 1.00 55.77 ? 158 HIS B NE2 1 ATOM 4111 N N . GLY B 1 175 ? -4.699 -17.499 -52.460 1.00 29.75 ? 159 GLY B N 1 ATOM 4112 C CA . GLY B 1 175 ? -4.451 -18.880 -52.132 1.00 21.85 ? 159 GLY B CA 1 ATOM 4113 C C . GLY B 1 175 ? -5.602 -19.284 -51.250 1.00 19.71 ? 159 GLY B C 1 ATOM 4114 O O . GLY B 1 175 ? -6.062 -18.482 -50.448 1.00 22.61 ? 159 GLY B O 1 ATOM 4115 N N . THR B 1 176 ? -6.067 -20.519 -51.418 1.00 19.96 ? 160 THR B N 1 ATOM 4116 C CA . THR B 1 176 ? -7.097 -21.113 -50.575 1.00 16.95 ? 160 THR B CA 1 ATOM 4117 C C . THR B 1 176 ? -6.439 -21.797 -49.402 1.00 12.61 ? 160 THR B C 1 ATOM 4118 O O . THR B 1 176 ? -5.586 -22.652 -49.590 1.00 12.63 ? 160 THR B O 1 ATOM 4119 C CB . THR B 1 176 ? -7.860 -22.206 -51.332 1.00 16.19 ? 160 THR B CB 1 ATOM 4120 O OG1 . THR B 1 176 ? -8.270 -21.713 -52.604 1.00 23.84 ? 160 THR B OG1 1 ATOM 4121 C CG2 . THR B 1 176 ? -9.075 -22.650 -50.572 1.00 14.53 ? 160 THR B CG2 1 ATOM 4122 N N . ILE B 1 177 ? -6.831 -21.433 -48.190 1.00 12.27 ? 161 ILE B N 1 ATOM 4123 C CA . ILE B 1 177 ? -6.272 -22.071 -47.012 1.00 12.37 ? 161 ILE B CA 1 ATOM 4124 C C . ILE B 1 177 ? -7.146 -23.259 -46.617 1.00 11.98 ? 161 ILE B C 1 ATOM 4125 O O . ILE B 1 177 ? -8.289 -23.093 -46.219 1.00 11.95 ? 161 ILE B O 1 ATOM 4126 C CB . ILE B 1 177 ? -6.129 -21.084 -45.849 1.00 11.58 ? 161 ILE B CB 1 ATOM 4127 C CG1 . ILE B 1 177 ? -5.228 -19.925 -46.276 1.00 14.18 ? 161 ILE B CG1 1 ATOM 4128 C CG2 . ILE B 1 177 ? -5.536 -21.791 -44.642 1.00 11.44 ? 161 ILE B CG2 1 ATOM 4129 C CD1 . ILE B 1 177 ? -5.444 -18.666 -45.523 1.00 17.57 ? 161 ILE B CD1 1 ATOM 4130 N N . ALA B 1 178 ? -6.594 -24.462 -46.748 1.00 11.36 ? 162 ALA B N 1 ATOM 4131 C CA . ALA B 1 178 ? -7.288 -25.670 -46.345 1.00 9.54 ? 162 ALA B CA 1 ATOM 4132 C C . ALA B 1 178 ? -6.908 -26.028 -44.923 1.00 9.86 ? 162 ALA B C 1 ATOM 4133 O O . ALA B 1 178 ? -5.774 -25.815 -44.498 1.00 12.77 ? 162 ALA B O 1 ATOM 4134 C CB . ALA B 1 178 ? -6.949 -26.805 -47.279 1.00 10.28 ? 162 ALA B CB 1 ATOM 4135 N N . THR B 1 179 ? -7.866 -26.554 -44.174 1.00 11.15 ? 163 THR B N 1 ATOM 4136 C CA . THR B 1 179 ? -7.608 -26.976 -42.809 1.00 11.53 ? 163 THR B CA 1 ATOM 4137 C C . THR B 1 179 ? -7.545 -28.499 -42.741 1.00 12.80 ? 163 THR B C 1 ATOM 4138 O O . THR B 1 179 ? -8.451 -29.183 -43.200 1.00 11.94 ? 163 THR B O 1 ATOM 4139 C CB . THR B 1 179 ? -8.678 -26.464 -41.843 1.00 9.98 ? 163 THR B CB 1 ATOM 4140 O OG1 . THR B 1 179 ? -8.877 -25.063 -42.043 1.00 12.21 ? 163 THR B OG1 1 ATOM 4141 C CG2 . THR B 1 179 ? -8.238 -26.710 -40.425 1.00 12.65 ? 163 THR B CG2 1 ATOM 4142 N N . ILE B 1 180 ? -6.461 -29.016 -42.175 1.00 9.39 ? 164 ILE B N 1 ATOM 4143 C CA . ILE B 1 180 ? -6.231 -30.449 -42.074 1.00 9.95 ? 164 ILE B CA 1 ATOM 4144 C C . ILE B 1 180 ? -6.036 -30.857 -40.610 1.00 8.36 ? 164 ILE B C 1 ATOM 4145 O O . ILE B 1 180 ? -5.288 -30.220 -39.863 1.00 7.35 ? 164 ILE B O 1 ATOM 4146 C CB . ILE B 1 180 ? -4.948 -30.864 -42.835 1.00 9.40 ? 164 ILE B CB 1 ATOM 4147 C CG1 . ILE B 1 180 ? -5.031 -30.479 -44.320 1.00 9.21 ? 164 ILE B CG1 1 ATOM 4148 C CG2 . ILE B 1 180 ? -4.679 -32.337 -42.630 1.00 8.16 ? 164 ILE B CG2 1 ATOM 4149 C CD1 . ILE B 1 180 ? -6.037 -31.248 -45.123 1.00 10.53 ? 164 ILE B CD1 1 ATOM 4150 N N . THR B 1 181 ? -6.699 -31.932 -40.217 1.00 8.04 ? 165 THR B N 1 ATOM 4151 C CA . THR B 1 181 ? -6.580 -32.479 -38.876 1.00 8.66 ? 165 THR B CA 1 ATOM 4152 C C . THR B 1 181 ? -6.393 -33.990 -38.969 1.00 7.63 ? 165 THR B C 1 ATOM 4153 O O . THR B 1 181 ? -6.666 -34.573 -40.004 1.00 7.67 ? 165 THR B O 1 ATOM 4154 C CB . THR B 1 181 ? -7.846 -32.239 -38.073 1.00 7.88 ? 165 THR B CB 1 ATOM 4155 O OG1 . THR B 1 181 ? -8.841 -33.165 -38.511 1.00 8.25 ? 165 THR B OG1 1 ATOM 4156 C CG2 . THR B 1 181 ? -8.347 -30.833 -38.260 1.00 8.08 ? 165 THR B CG2 1 ATOM 4157 N N . PRO B 1 182 ? -5.917 -34.629 -37.885 1.00 6.71 ? 166 PRO B N 1 ATOM 4158 C CA . PRO B 1 182 ? -5.805 -36.092 -37.868 1.00 7.23 ? 166 PRO B CA 1 ATOM 4159 C C . PRO B 1 182 ? -7.081 -36.841 -38.279 1.00 7.86 ? 166 PRO B C 1 ATOM 4160 O O . PRO B 1 182 ? -7.019 -37.751 -39.084 1.00 8.68 ? 166 PRO B O 1 ATOM 4161 C CB . PRO B 1 182 ? -5.426 -36.378 -36.425 1.00 8.32 ? 166 PRO B CB 1 ATOM 4162 C CG . PRO B 1 182 ? -4.605 -35.175 -36.038 1.00 8.51 ? 166 PRO B CG 1 ATOM 4163 C CD . PRO B 1 182 ? -5.269 -34.015 -36.711 1.00 6.13 ? 166 PRO B CD 1 ATOM 4164 N N . GLN B 1 183 ? -8.228 -36.435 -37.762 1.00 9.08 ? 167 GLN B N 1 ATOM 4165 C CA . GLN B 1 183 ? -9.493 -37.083 -38.078 1.00 11.34 ? 167 GLN B CA 1 ATOM 4166 C C . GLN B 1 183 ? -10.139 -36.685 -39.426 1.00 8.64 ? 167 GLN B C 1 ATOM 4167 O O . GLN B 1 183 ? -10.900 -37.456 -39.994 1.00 9.16 ? 167 GLN B O 1 ATOM 4168 C CB . GLN B 1 183 ? -10.469 -36.818 -36.948 1.00 8.60 ? 167 GLN B CB 1 ATOM 4169 C CG . GLN B 1 183 ? -10.049 -37.379 -35.638 1.00 6.98 ? 167 GLN B CG 1 ATOM 4170 C CD . GLN B 1 183 ? -11.131 -37.187 -34.616 1.00 10.53 ? 167 GLN B CD 1 ATOM 4171 O OE1 . GLN B 1 183 ? -11.998 -38.045 -34.454 1.00 13.35 ? 167 GLN B OE1 1 ATOM 4172 N NE2 . GLN B 1 183 ? -11.115 -36.046 -33.941 1.00 11.31 ? 167 GLN B NE2 1 ATOM 4173 N N . ALA B 1 184 ? -9.867 -35.481 -39.907 1.00 6.98 ? 168 ALA B N 1 ATOM 4174 C CA . ALA B 1 184 ? -10.324 -35.046 -41.211 1.00 7.43 ? 168 ALA B CA 1 ATOM 4175 C C . ALA B 1 184 ? -9.074 -34.755 -42.049 1.00 8.15 ? 168 ALA B C 1 ATOM 4176 O O . ALA B 1 184 ? -8.649 -33.618 -42.195 1.00 7.08 ? 168 ALA B O 1 ATOM 4177 C CB . ALA B 1 184 ? -11.182 -33.814 -41.063 1.00 8.27 ? 168 ALA B CB 1 ATOM 4178 N N . PRO B 1 185 ? -8.434 -35.811 -42.553 1.00 8.72 ? 169 PRO B N 1 ATOM 4179 C CA . PRO B 1 185 ? -7.167 -35.647 -43.264 1.00 10.32 ? 169 PRO B CA 1 ATOM 4180 C C . PRO B 1 185 ? -7.269 -35.047 -44.670 1.00 11.64 ? 169 PRO B C 1 ATOM 4181 O O . PRO B 1 185 ? -6.281 -34.537 -45.178 1.00 10.72 ? 169 PRO B O 1 ATOM 4182 C CB . PRO B 1 185 ? -6.639 -37.081 -43.338 1.00 11.93 ? 169 PRO B CB 1 ATOM 4183 C CG . PRO B 1 185 ? -7.847 -37.951 -43.150 1.00 9.39 ? 169 PRO B CG 1 ATOM 4184 C CD . PRO B 1 185 ? -8.694 -37.223 -42.219 1.00 8.48 ? 169 PRO B CD 1 ATOM 4185 N N . THR B 1 186 ? -8.447 -35.109 -45.279 1.00 12.43 ? 170 THR B N 1 ATOM 4186 C CA . THR B 1 186 ? -8.604 -34.726 -46.674 1.00 11.33 ? 170 THR B CA 1 ATOM 4187 C C . THR B 1 186 ? -9.345 -33.409 -46.797 1.00 13.24 ? 170 THR B C 1 ATOM 4188 O O . THR B 1 186 ? -10.266 -33.139 -46.045 1.00 17.79 ? 170 THR B O 1 ATOM 4189 C CB . THR B 1 186 ? -9.350 -35.815 -47.486 1.00 18.43 ? 170 THR B CB 1 ATOM 4190 O OG1 . THR B 1 186 ? -10.719 -35.858 -47.086 1.00 21.90 ? 170 THR B OG1 1 ATOM 4191 C CG2 . THR B 1 186 ? -8.727 -37.180 -47.269 1.00 16.98 ? 170 THR B CG2 1 ATOM 4192 N N . SER B 1 187 ? -8.920 -32.577 -47.732 1.00 13.02 ? 171 SER B N 1 ATOM 4193 C CA . SER B 1 187 ? -9.677 -31.398 -48.092 1.00 11.73 ? 171 SER B CA 1 ATOM 4194 C C . SER B 1 187 ? -9.798 -31.370 -49.602 1.00 11.49 ? 171 SER B C 1 ATOM 4195 O O . SER B 1 187 ? -8.866 -31.711 -50.313 1.00 11.72 ? 171 SER B O 1 ATOM 4196 C CB . SER B 1 187 ? -9.006 -30.133 -47.573 1.00 10.91 ? 171 SER B CB 1 ATOM 4197 O OG . SER B 1 187 ? -9.871 -29.025 -47.723 1.00 18.67 ? 171 SER B OG 1 ATOM 4198 N N . GLU B 1 188 ? -10.967 -30.983 -50.086 1.00 11.78 ? 172 GLU B N 1 ATOM 4199 C CA . GLU B 1 188 ? -11.191 -30.879 -51.508 1.00 13.36 ? 172 GLU B CA 1 ATOM 4200 C C . GLU B 1 188 ? -11.315 -29.413 -51.820 1.00 13.35 ? 172 GLU B C 1 ATOM 4201 O O . GLU B 1 188 ? -12.068 -28.695 -51.179 1.00 18.77 ? 172 GLU B O 1 ATOM 4202 C CB . GLU B 1 188 ? -12.469 -31.597 -51.907 1.00 20.82 ? 172 GLU B CB 1 ATOM 4203 C CG . GLU B 1 188 ? -12.727 -32.863 -51.146 1.00 21.28 ? 172 GLU B CG 1 ATOM 4204 C CD . GLU B 1 188 ? -12.514 -34.107 -51.980 1.00 26.09 ? 172 GLU B CD 1 ATOM 4205 O OE1 . GLU B 1 188 ? -12.048 -35.130 -51.422 1.00 23.24 ? 172 GLU B OE1 1 ATOM 4206 O OE2 . GLU B 1 188 ? -12.832 -34.078 -53.188 1.00 28.66 ? 172 GLU B OE2 1 ATOM 4207 N N . ILE B 1 189 ? -10.571 -28.951 -52.797 1.00 12.80 ? 173 ILE B N 1 ATOM 4208 C CA . ILE B 1 189 ? -10.678 -27.566 -53.194 1.00 16.97 ? 173 ILE B CA 1 ATOM 4209 C C . ILE B 1 189 ? -10.738 -27.470 -54.715 1.00 15.67 ? 173 ILE B C 1 ATOM 4210 O O . ILE B 1 189 ? -10.160 -28.283 -55.425 1.00 15.38 ? 173 ILE B O 1 ATOM 4211 C CB . ILE B 1 189 ? -9.543 -26.708 -52.562 1.00 17.18 ? 173 ILE B CB 1 ATOM 4212 C CG1 . ILE B 1 189 ? -8.159 -27.317 -52.796 1.00 17.02 ? 173 ILE B CG1 1 ATOM 4213 C CG2 . ILE B 1 189 ? -9.778 -26.561 -51.053 1.00 17.73 ? 173 ILE B CG2 1 ATOM 4214 C CD1 . ILE B 1 189 ? -7.187 -27.122 -51.618 1.00 13.60 ? 173 ILE B CD1 1 ATOM 4215 N N . GLN B 1 190 ? -11.490 -26.503 -55.214 1.00 17.98 ? 174 GLN B N 1 ATOM 4216 C CA . GLN B 1 190 ? -11.662 -26.347 -56.655 1.00 18.59 ? 174 GLN B CA 1 ATOM 4217 C C . GLN B 1 190 ? -10.704 -25.275 -57.113 1.00 16.58 ? 174 GLN B C 1 ATOM 4218 O O . GLN B 1 190 ? -10.795 -24.148 -56.660 1.00 19.23 ? 174 GLN B O 1 ATOM 4219 C CB . GLN B 1 190 ? -13.106 -25.946 -56.980 1.00 20.77 ? 174 GLN B CB 1 ATOM 4220 C CG . GLN B 1 190 ? -13.591 -26.365 -58.374 1.00 22.39 ? 174 GLN B CG 1 ATOM 4221 C CD . GLN B 1 190 ? -13.899 -27.848 -58.482 1.00 16.61 ? 174 GLN B CD 1 ATOM 4222 O OE1 . GLN B 1 190 ? -14.167 -28.518 -57.492 1.00 22.73 ? 174 GLN B OE1 1 ATOM 4223 N NE2 . GLN B 1 190 ? -13.853 -28.363 -59.697 1.00 24.03 ? 174 GLN B NE2 1 ATOM 4224 N N . LEU B 1 191 ? -9.771 -25.625 -57.992 1.00 16.61 ? 175 LEU B N 1 ATOM 4225 C CA . LEU B 1 191 ? -8.738 -24.685 -58.424 1.00 17.81 ? 175 LEU B CA 1 ATOM 4226 C C . LEU B 1 191 ? -8.967 -24.111 -59.830 1.00 23.86 ? 175 LEU B C 1 ATOM 4227 O O . LEU B 1 191 ? -9.591 -24.743 -60.698 1.00 20.63 ? 175 LEU B O 1 ATOM 4228 C CB . LEU B 1 191 ? -7.381 -25.366 -58.403 1.00 19.34 ? 175 LEU B CB 1 ATOM 4229 C CG . LEU B 1 191 ? -6.893 -25.843 -57.049 1.00 15.96 ? 175 LEU B CG 1 ATOM 4230 C CD1 . LEU B 1 191 ? -5.573 -26.562 -57.256 1.00 17.52 ? 175 LEU B CD1 1 ATOM 4231 C CD2 . LEU B 1 191 ? -6.763 -24.683 -56.067 1.00 17.02 ? 175 LEU B CD2 1 ATOM 4232 N N . THR B 1 192 ? -8.454 -22.908 -60.053 1.00 21.56 ? 176 THR B N 1 ATOM 4233 C CA . THR B 1 192 ? -8.527 -22.317 -61.372 1.00 28.84 ? 176 THR B CA 1 ATOM 4234 C C . THR B 1 192 ? -7.622 -23.086 -62.314 1.00 27.40 ? 176 THR B C 1 ATOM 4235 O O . THR B 1 192 ? -6.471 -23.357 -61.998 1.00 31.16 ? 176 THR B O 1 ATOM 4236 C CB . THR B 1 192 ? -8.106 -20.840 -61.369 1.00 29.56 ? 176 THR B CB 1 ATOM 4237 O OG1 . THR B 1 192 ? -9.034 -20.075 -60.594 1.00 34.70 ? 176 THR B OG1 1 ATOM 4238 C CG2 . THR B 1 192 ? -8.081 -20.299 -62.781 1.00 33.38 ? 176 THR B CG2 1 ATOM 4239 N N . ASP B 1 193 ? -8.166 -23.458 -63.463 1.00 24.10 ? 177 ASP B N 1 ATOM 4240 C CA . ASP B 1 193 ? -7.419 -24.150 -64.503 1.00 24.98 ? 177 ASP B CA 1 ATOM 4241 C C . ASP B 1 193 ? -7.107 -25.612 -64.154 1.00 21.99 ? 177 ASP B C 1 ATOM 4242 O O . ASP B 1 193 ? -6.984 -26.435 -65.053 1.00 21.23 ? 177 ASP B O 1 ATOM 4243 C CB . ASP B 1 193 ? -6.146 -23.366 -64.872 1.00 31.94 ? 177 ASP B CB 1 ATOM 4244 C CG . ASP B 1 193 ? -6.369 -22.373 -66.029 1.00 38.62 ? 177 ASP B CG 1 ATOM 4245 O OD1 . ASP B 1 193 ? -6.801 -22.804 -67.121 1.00 47.46 ? 177 ASP B OD1 1 ATOM 4246 O OD2 . ASP B 1 193 ? -6.120 -21.155 -65.859 1.00 44.85 ? 177 ASP B OD2 1 ATOM 4247 N N . TYR B 1 194 ? -7.014 -25.941 -62.864 1.00 21.12 ? 178 TYR B N 1 ATOM 4248 C CA . TYR B 1 194 ? -6.642 -27.301 -62.430 1.00 19.73 ? 178 TYR B CA 1 ATOM 4249 C C . TYR B 1 194 ? -7.832 -28.191 -62.067 1.00 20.92 ? 178 TYR B C 1 ATOM 4250 O O . TYR B 1 194 ? -7.713 -29.419 -62.039 1.00 24.71 ? 178 TYR B O 1 ATOM 4251 C CB . TYR B 1 194 ? -5.703 -27.261 -61.214 1.00 20.66 ? 178 TYR B CB 1 ATOM 4252 C CG . TYR B 1 194 ? -4.250 -26.981 -61.529 1.00 21.60 ? 178 TYR B CG 1 ATOM 4253 C CD1 . TYR B 1 194 ? -3.772 -25.680 -61.585 1.00 19.10 ? 178 TYR B CD1 1 ATOM 4254 C CD2 . TYR B 1 194 ? -3.355 -28.022 -61.760 1.00 19.87 ? 178 TYR B CD2 1 ATOM 4255 C CE1 . TYR B 1 194 ? -2.473 -25.425 -61.877 1.00 17.02 ? 178 TYR B CE1 1 ATOM 4256 C CE2 . TYR B 1 194 ? -2.041 -27.771 -62.041 1.00 16.55 ? 178 TYR B CE2 1 ATOM 4257 C CZ . TYR B 1 194 ? -1.607 -26.475 -62.091 1.00 18.25 ? 178 TYR B CZ 1 ATOM 4258 O OH . TYR B 1 194 ? -0.287 -26.249 -62.369 1.00 20.82 ? 178 TYR B OH 1 ATOM 4259 N N . GLY B 1 195 ? -8.972 -27.584 -61.757 1.00 21.55 ? 179 GLY B N 1 ATOM 4260 C CA . GLY B 1 195 ? -10.146 -28.350 -61.374 1.00 19.06 ? 179 GLY B CA 1 ATOM 4261 C C . GLY B 1 195 ? -10.138 -28.766 -59.907 1.00 18.86 ? 179 GLY B C 1 ATOM 4262 O O . GLY B 1 195 ? -9.600 -28.061 -59.054 1.00 18.85 ? 179 GLY B O 1 ATOM 4263 N N . ALA B 1 196 ? -10.763 -29.902 -59.614 1.00 16.64 ? 180 ALA B N 1 ATOM 4264 C CA . ALA B 1 196 ? -10.846 -30.404 -58.251 1.00 16.76 ? 180 ALA B CA 1 ATOM 4265 C C . ALA B 1 196 ? -9.535 -31.067 -57.804 1.00 16.03 ? 180 ALA B C 1 ATOM 4266 O O . ALA B 1 196 ? -9.021 -31.983 -58.444 1.00 16.59 ? 180 ALA B O 1 ATOM 4267 C CB . ALA B 1 196 ? -12.026 -31.358 -58.113 1.00 14.35 ? 180 ALA B CB 1 ATOM 4268 N N . LEU B 1 197 ? -8.989 -30.550 -56.710 1.00 14.89 ? 181 LEU B N 1 ATOM 4269 C CA . LEU B 1 197 ? -7.775 -31.071 -56.100 1.00 13.22 ? 181 LEU B CA 1 ATOM 4270 C C . LEU B 1 197 ? -8.119 -31.609 -54.732 1.00 12.30 ? 181 LEU B C 1 ATOM 4271 O O . LEU B 1 197 ? -8.712 -30.912 -53.934 1.00 15.87 ? 181 LEU B O 1 ATOM 4272 C CB . LEU B 1 197 ? -6.750 -29.952 -55.931 1.00 15.79 ? 181 LEU B CB 1 ATOM 4273 C CG . LEU B 1 197 ? -5.459 -30.301 -55.186 1.00 13.28 ? 181 LEU B CG 1 ATOM 4274 C CD1 . LEU B 1 197 ? -4.597 -31.148 -56.085 1.00 11.04 ? 181 LEU B CD1 1 ATOM 4275 C CD2 . LEU B 1 197 ? -4.695 -29.064 -54.724 1.00 15.12 ? 181 LEU B CD2 1 ATOM 4276 N N . THR B 1 198 ? -7.754 -32.845 -54.441 1.00 10.73 ? 182 THR B N 1 ATOM 4277 C CA . THR B 1 198 ? -7.860 -33.327 -53.081 1.00 10.58 ? 182 THR B CA 1 ATOM 4278 C C . THR B 1 198 ? -6.485 -33.322 -52.448 1.00 9.37 ? 182 THR B C 1 ATOM 4279 O O . THR B 1 198 ? -5.558 -33.869 -53.021 1.00 10.25 ? 182 THR B O 1 ATOM 4280 C CB . THR B 1 198 ? -8.416 -34.731 -53.050 1.00 12.82 ? 182 THR B CB 1 ATOM 4281 O OG1 . THR B 1 198 ? -9.563 -34.785 -53.898 1.00 16.95 ? 182 THR B OG1 1 ATOM 4282 C CG2 . THR B 1 198 ? -8.802 -35.141 -51.634 1.00 13.45 ? 182 THR B CG2 1 ATOM 4283 N N . LEU B 1 199 ? -6.365 -32.647 -51.302 1.00 11.07 ? 183 LEU B N 1 ATOM 4284 C CA . LEU B 1 199 ? -5.218 -32.753 -50.397 1.00 9.43 ? 183 LEU B CA 1 ATOM 4285 C C . LEU B 1 199 ? -5.545 -33.843 -49.443 1.00 7.97 ? 183 LEU B C 1 ATOM 4286 O O . LEU B 1 199 ? -6.552 -33.773 -48.776 1.00 11.55 ? 183 LEU B O 1 ATOM 4287 C CB . LEU B 1 199 ? -5.070 -31.511 -49.532 1.00 10.54 ? 183 LEU B CB 1 ATOM 4288 C CG . LEU B 1 199 ? -4.437 -30.258 -50.090 1.00 16.53 ? 183 LEU B CG 1 ATOM 4289 C CD1 . LEU B 1 199 ? -2.997 -30.520 -50.491 1.00 16.16 ? 183 LEU B CD1 1 ATOM 4290 C CD2 . LEU B 1 199 ? -5.250 -29.828 -51.251 1.00 15.85 ? 183 LEU B CD2 1 ATOM 4291 N N . ASP B 1 200 ? -4.703 -34.847 -49.354 1.00 9.24 ? 184 ASP B N 1 ATOM 4292 C CA . ASP B 1 200 ? -4.853 -35.860 -48.331 1.00 10.36 ? 184 ASP B CA 1 ATOM 4293 C C . ASP B 1 200 ? -3.544 -35.866 -47.540 1.00 12.27 ? 184 ASP B C 1 ATOM 4294 O O . ASP B 1 200 ? -2.517 -36.313 -48.036 1.00 11.38 ? 184 ASP B O 1 ATOM 4295 C CB . ASP B 1 200 ? -5.144 -37.217 -48.976 1.00 11.37 ? 184 ASP B CB 1 ATOM 4296 C CG . ASP B 1 200 ? -5.510 -38.292 -47.960 1.00 16.16 ? 184 ASP B CG 1 ATOM 4297 O OD1 . ASP B 1 200 ? -5.316 -38.064 -46.757 1.00 17.34 ? 184 ASP B OD1 1 ATOM 4298 O OD2 . ASP B 1 200 ? -5.987 -39.372 -48.365 1.00 18.82 ? 184 ASP B OD2 1 ATOM 4299 N N . CYS B 1 201 ? -3.568 -35.321 -46.326 1.00 13.11 ? 185 CYS B N 1 ATOM 4300 C CA . CYS B 1 201 ? -2.337 -35.065 -45.567 1.00 10.87 ? 185 CYS B CA 1 ATOM 4301 C C . CYS B 1 201 ? -2.325 -35.781 -44.219 1.00 14.52 ? 185 CYS B C 1 ATOM 4302 O O . CYS B 1 201 ? -3.364 -35.940 -43.590 1.00 15.98 ? 185 CYS B O 1 ATOM 4303 C CB . CYS B 1 201 ? -2.168 -33.562 -45.313 1.00 12.17 ? 185 CYS B CB 1 ATOM 4304 S SG . CYS B 1 201 ? -2.053 -32.520 -46.758 1.00 15.63 ? 185 CYS B SG 1 ATOM 4305 N N . SER B 1 202 ? -1.149 -36.186 -43.758 1.00 12.88 ? 186 SER B N 1 ATOM 4306 C CA . SER B 1 202 ? -1.025 -36.752 -42.418 1.00 13.45 ? 186 SER B CA 1 ATOM 4307 C C . SER B 1 202 ? 0.296 -36.309 -41.765 1.00 12.90 ? 186 SER B C 1 ATOM 4308 O O . SER B 1 202 ? 1.280 -36.084 -42.462 1.00 13.71 ? 186 SER B O 1 ATOM 4309 C CB . SER B 1 202 ? -1.140 -38.267 -42.480 1.00 14.40 ? 186 SER B CB 1 ATOM 4310 O OG . SER B 1 202 ? 0.009 -38.867 -43.029 1.00 25.53 ? 186 SER B OG 1 ATOM 4311 N N . PRO B 1 203 ? 0.313 -36.124 -40.431 1.00 10.52 ? 187 PRO B N 1 ATOM 4312 C CA . PRO B 1 203 ? 1.552 -35.659 -39.791 1.00 11.27 ? 187 PRO B CA 1 ATOM 4313 C C . PRO B 1 203 ? 2.674 -36.631 -40.054 1.00 12.88 ? 187 PRO B C 1 ATOM 4314 O O . PRO B 1 203 ? 2.443 -37.824 -40.031 1.00 12.98 ? 187 PRO B O 1 ATOM 4315 C CB . PRO B 1 203 ? 1.212 -35.662 -38.300 1.00 10.48 ? 187 PRO B CB 1 ATOM 4316 C CG . PRO B 1 203 ? -0.239 -35.525 -38.245 1.00 12.01 ? 187 PRO B CG 1 ATOM 4317 C CD . PRO B 1 203 ? -0.774 -36.270 -39.452 1.00 12.92 ? 187 PRO B CD 1 ATOM 4318 N N . ARG B 1 204 ? 3.868 -36.134 -40.316 1.00 12.67 ? 188 ARG B N 1 ATOM 4319 C CA . ARG B 1 204 ? 5.034 -36.981 -40.374 1.00 13.25 ? 188 ARG B CA 1 ATOM 4320 C C . ARG B 1 204 ? 5.370 -37.484 -38.975 1.00 15.99 ? 188 ARG B C 1 ATOM 4321 O O . ARG B 1 204 ? 5.234 -36.745 -38.000 1.00 17.92 ? 188 ARG B O 1 ATOM 4322 C CB . ARG B 1 204 ? 6.199 -36.176 -40.924 1.00 17.89 ? 188 ARG B CB 1 ATOM 4323 C CG . ARG B 1 204 ? 5.956 -35.655 -42.339 1.00 17.15 ? 188 ARG B CG 1 ATOM 4324 C CD . ARG B 1 204 ? 7.255 -35.316 -43.000 1.00 15.73 ? 188 ARG B CD 1 ATOM 4325 N NE . ARG B 1 204 ? 7.853 -36.509 -43.570 1.00 20.61 ? 188 ARG B NE 1 ATOM 4326 C CZ . ARG B 1 204 ? 9.150 -36.655 -43.825 1.00 23.73 ? 188 ARG B CZ 1 ATOM 4327 N NH1 . ARG B 1 204 ? 10.016 -35.674 -43.562 1.00 21.64 ? 188 ARG B NH1 1 ATOM 4328 N NH2 . ARG B 1 204 ? 9.581 -37.790 -44.351 1.00 25.51 ? 188 ARG B NH2 1 ATOM 4329 N N . THR B 1 205 ? 5.814 -38.734 -38.866 1.00 17.03 ? 189 THR B N 1 ATOM 4330 C CA . THR B 1 205 ? 6.281 -39.283 -37.581 1.00 15.42 ? 189 THR B CA 1 ATOM 4331 C C . THR B 1 205 ? 7.408 -38.441 -36.962 1.00 14.15 ? 189 THR B C 1 ATOM 4332 O O . THR B 1 205 ? 8.435 -38.196 -37.586 1.00 15.52 ? 189 THR B O 1 ATOM 4333 C CB . THR B 1 205 ? 6.770 -40.741 -37.747 1.00 17.25 ? 189 THR B CB 1 ATOM 4334 O OG1 . THR B 1 205 ? 5.693 -41.565 -38.199 1.00 18.99 ? 189 THR B OG1 1 ATOM 4335 C CG2 . THR B 1 205 ? 7.281 -41.303 -36.446 1.00 12.40 ? 189 THR B CG2 1 ATOM 4336 N N . GLY B 1 206 ? 7.199 -37.990 -35.732 1.00 15.44 ? 190 GLY B N 1 ATOM 4337 C CA . GLY B 1 206 ? 8.192 -37.217 -34.997 1.00 15.68 ? 190 GLY B CA 1 ATOM 4338 C C . GLY B 1 206 ? 7.888 -37.187 -33.501 1.00 13.91 ? 190 GLY B C 1 ATOM 4339 O O . GLY B 1 206 ? 8.071 -38.171 -32.807 1.00 14.81 ? 190 GLY B O 1 ATOM 4340 N N . LEU B 1 207 ? 7.422 -36.047 -33.005 1.00 16.23 ? 191 LEU B N 1 ATOM 4341 C CA . LEU B 1 207 ? 6.903 -35.961 -31.643 1.00 16.20 ? 191 LEU B CA 1 ATOM 4342 C C . LEU B 1 207 ? 5.784 -36.951 -31.397 1.00 17.03 ? 191 LEU B C 1 ATOM 4343 O O . LEU B 1 207 ? 4.854 -37.039 -32.188 1.00 15.80 ? 191 LEU B O 1 ATOM 4344 C CB . LEU B 1 207 ? 6.306 -34.594 -31.397 1.00 19.77 ? 191 LEU B CB 1 ATOM 4345 C CG . LEU B 1 207 ? 7.157 -33.484 -30.835 1.00 21.22 ? 191 LEU B CG 1 ATOM 4346 C CD1 . LEU B 1 207 ? 6.228 -32.310 -30.549 1.00 18.29 ? 191 LEU B CD1 1 ATOM 4347 C CD2 . LEU B 1 207 ? 7.866 -33.971 -29.584 1.00 17.58 ? 191 LEU B CD2 1 ATOM 4348 N N . ASP B 1 208 ? 5.859 -37.652 -30.269 1.00 17.79 ? 192 ASP B N 1 ATOM 4349 C CA . ASP B 1 208 ? 4.881 -38.665 -29.917 1.00 14.97 ? 192 ASP B CA 1 ATOM 4350 C C . ASP B 1 208 ? 4.008 -38.189 -28.753 1.00 11.12 ? 192 ASP B C 1 ATOM 4351 O O . ASP B 1 208 ? 4.471 -38.042 -27.651 1.00 10.72 ? 192 ASP B O 1 ATOM 4352 C CB . ASP B 1 208 ? 5.606 -39.966 -29.566 1.00 12.61 ? 192 ASP B CB 1 ATOM 4353 C CG . ASP B 1 208 ? 4.674 -41.123 -29.433 1.00 13.53 ? 192 ASP B CG 1 ATOM 4354 O OD1 . ASP B 1 208 ? 3.461 -40.879 -29.387 1.00 18.99 ? 192 ASP B OD1 1 ATOM 4355 O OD2 . ASP B 1 208 ? 5.136 -42.276 -29.358 1.00 19.00 ? 192 ASP B OD2 1 ATOM 4356 N N . PHE B 1 209 ? 2.731 -37.961 -29.021 1.00 15.65 ? 193 PHE B N 1 ATOM 4357 C CA . PHE B 1 209 ? 1.804 -37.428 -28.029 1.00 13.58 ? 193 PHE B CA 1 ATOM 4358 C C . PHE B 1 209 ? 1.097 -38.480 -27.196 1.00 11.08 ? 193 PHE B C 1 ATOM 4359 O O . PHE B 1 209 ? 0.329 -38.143 -26.297 1.00 13.16 ? 193 PHE B O 1 ATOM 4360 C CB . PHE B 1 209 ? 0.767 -36.552 -28.709 1.00 11.41 ? 193 PHE B CB 1 ATOM 4361 C CG . PHE B 1 209 ? 1.340 -35.314 -29.300 1.00 15.51 ? 193 PHE B CG 1 ATOM 4362 C CD1 . PHE B 1 209 ? 1.942 -34.381 -28.489 1.00 15.46 ? 193 PHE B CD1 1 ATOM 4363 C CD2 . PHE B 1 209 ? 1.276 -35.080 -30.651 1.00 14.80 ? 193 PHE B CD2 1 ATOM 4364 C CE1 . PHE B 1 209 ? 2.469 -33.235 -29.008 1.00 17.05 ? 193 PHE B CE1 1 ATOM 4365 C CE2 . PHE B 1 209 ? 1.802 -33.945 -31.176 1.00 17.41 ? 193 PHE B CE2 1 ATOM 4366 C CZ . PHE B 1 209 ? 2.407 -33.010 -30.346 1.00 16.58 ? 193 PHE B CZ 1 ATOM 4367 N N . ASN B 1 210 ? 1.362 -39.748 -27.472 1.00 12.24 ? 194 ASN B N 1 ATOM 4368 C CA . ASN B 1 210 ? 0.970 -40.798 -26.545 1.00 14.48 ? 194 ASN B CA 1 ATOM 4369 C C . ASN B 1 210 ? 1.957 -40.867 -25.410 1.00 13.62 ? 194 ASN B C 1 ATOM 4370 O O . ASN B 1 210 ? 1.628 -41.328 -24.327 1.00 20.29 ? 194 ASN B O 1 ATOM 4371 C CB . ASN B 1 210 ? 0.879 -42.159 -27.232 1.00 20.66 ? 194 ASN B CB 1 ATOM 4372 C CG . ASN B 1 210 ? -0.412 -42.337 -28.018 1.00 19.02 ? 194 ASN B CG 1 ATOM 4373 O OD1 . ASN B 1 210 ? -0.380 -42.732 -29.169 1.00 28.30 ? 194 ASN B OD1 1 ATOM 4374 N ND2 . ASN B 1 210 ? -1.548 -42.055 -27.393 1.00 20.78 ? 194 ASN B ND2 1 ATOM 4375 N N . GLU B 1 211 ? 3.172 -40.390 -25.670 1.00 14.12 ? 195 GLU B N 1 ATOM 4376 C CA . GLU B 1 211 ? 4.244 -40.313 -24.664 1.00 15.22 ? 195 GLU B CA 1 ATOM 4377 C C . GLU B 1 211 ? 4.539 -38.895 -24.105 1.00 10.47 ? 195 GLU B C 1 ATOM 4378 O O . GLU B 1 211 ? 4.844 -38.735 -22.932 1.00 10.73 ? 195 GLU B O 1 ATOM 4379 C CB . GLU B 1 211 ? 5.532 -40.897 -25.255 1.00 15.99 ? 195 GLU B CB 1 ATOM 4380 C CG . GLU B 1 211 ? 6.753 -40.795 -24.347 1.00 13.07 ? 195 GLU B CG 1 ATOM 4381 C CD . GLU B 1 211 ? 6.567 -41.510 -23.018 1.00 14.74 ? 195 GLU B CD 1 ATOM 4382 O OE1 . GLU B 1 211 ? 5.640 -42.342 -22.900 1.00 21.48 ? 195 GLU B OE1 1 ATOM 4383 O OE2 . GLU B 1 211 ? 7.355 -41.245 -22.096 1.00 13.03 ? 195 GLU B OE2 1 ATOM 4384 N N . MET B 1 212 ? 4.467 -37.875 -24.938 1.00 9.66 ? 196 MET B N 1 ATOM 4385 C CA . MET B 1 212 ? 4.882 -36.561 -24.497 1.00 11.16 ? 196 MET B CA 1 ATOM 4386 C C . MET B 1 212 ? 3.691 -35.779 -24.016 1.00 11.01 ? 196 MET B C 1 ATOM 4387 O O . MET B 1 212 ? 2.667 -35.731 -24.687 1.00 16.91 ? 196 MET B O 1 ATOM 4388 C CB . MET B 1 212 ? 5.578 -35.798 -25.620 1.00 11.64 ? 196 MET B CB 1 ATOM 4389 C CG . MET B 1 212 ? 6.908 -36.381 -26.050 1.00 9.98 ? 196 MET B CG 1 ATOM 4390 S SD . MET B 1 212 ? 7.918 -36.945 -24.699 1.00 11.04 ? 196 MET B SD 1 ATOM 4391 C CE . MET B 1 212 ? 8.474 -35.385 -24.071 1.00 9.27 ? 196 MET B CE 1 ATOM 4392 N N . VAL B 1 213 ? 3.824 -35.170 -22.847 1.00 9.66 ? 197 VAL B N 1 ATOM 4393 C CA . VAL B 1 213 ? 2.743 -34.374 -22.292 1.00 10.82 ? 197 VAL B CA 1 ATOM 4394 C C . VAL B 1 213 ? 3.184 -32.905 -22.186 1.00 11.32 ? 197 VAL B C 1 ATOM 4395 O O . VAL B 1 213 ? 4.365 -32.605 -22.028 1.00 11.87 ? 197 VAL B O 1 ATOM 4396 C CB . VAL B 1 213 ? 2.220 -35.011 -20.973 1.00 10.05 ? 197 VAL B CB 1 ATOM 4397 C CG1 . VAL B 1 213 ? 2.251 -34.057 -19.822 1.00 10.38 ? 197 VAL B CG1 1 ATOM 4398 C CG2 . VAL B 1 213 ? 0.836 -35.531 -21.203 1.00 13.95 ? 197 VAL B CG2 1 ATOM 4399 N N . LEU B 1 214 ? 2.217 -32.013 -22.336 1.00 9.87 ? 198 LEU B N 1 ATOM 4400 C CA . LEU B 1 214 ? 2.433 -30.577 -22.342 1.00 10.67 ? 198 LEU B CA 1 ATOM 4401 C C . LEU B 1 214 ? 2.258 -30.003 -20.937 1.00 9.47 ? 198 LEU B C 1 ATOM 4402 O O . LEU B 1 214 ? 1.171 -30.000 -20.397 1.00 9.35 ? 198 LEU B O 1 ATOM 4403 C CB . LEU B 1 214 ? 1.448 -29.964 -23.335 1.00 12.91 ? 198 LEU B CB 1 ATOM 4404 C CG . LEU B 1 214 ? 1.096 -28.477 -23.358 1.00 17.90 ? 198 LEU B CG 1 ATOM 4405 C CD1 . LEU B 1 214 ? 2.290 -27.617 -23.041 1.00 21.30 ? 198 LEU B CD1 1 ATOM 4406 C CD2 . LEU B 1 214 ? 0.539 -28.121 -24.727 1.00 15.45 ? 198 LEU B CD2 1 ATOM 4407 N N . LEU B 1 215 ? 3.349 -29.535 -20.349 1.00 9.12 ? 199 LEU B N 1 ATOM 4408 C CA . LEU B 1 215 ? 3.343 -29.042 -18.983 1.00 11.74 ? 199 LEU B CA 1 ATOM 4409 C C . LEU B 1 215 ? 3.415 -27.515 -18.979 1.00 13.13 ? 199 LEU B C 1 ATOM 4410 O O . LEU B 1 215 ? 4.278 -26.943 -19.601 1.00 11.94 ? 199 LEU B O 1 ATOM 4411 C CB . LEU B 1 215 ? 4.510 -29.663 -18.191 1.00 10.65 ? 199 LEU B CB 1 ATOM 4412 C CG . LEU B 1 215 ? 4.613 -29.428 -16.671 1.00 9.44 ? 199 LEU B CG 1 ATOM 4413 C CD1 . LEU B 1 215 ? 5.613 -30.354 -15.982 1.00 13.03 ? 199 LEU B CD1 1 ATOM 4414 C CD2 . LEU B 1 215 ? 5.006 -28.001 -16.384 1.00 14.74 ? 199 LEU B CD2 1 ATOM 4415 N N . THR B 1 216 ? 2.509 -26.871 -18.252 1.00 11.18 ? 200 THR B N 1 ATOM 4416 C CA . THR B 1 216 ? 2.404 -25.410 -18.217 1.00 17.59 ? 200 THR B CA 1 ATOM 4417 C C . THR B 1 216 ? 2.562 -24.892 -16.777 1.00 19.11 ? 200 THR B C 1 ATOM 4418 O O . THR B 1 216 ? 1.809 -25.281 -15.905 1.00 18.98 ? 200 THR B O 1 ATOM 4419 C CB . THR B 1 216 ? 1.016 -24.967 -18.751 1.00 18.27 ? 200 THR B CB 1 ATOM 4420 O OG1 . THR B 1 216 ? -0.011 -25.717 -18.096 1.00 28.68 ? 200 THR B OG1 1 ATOM 4421 C CG2 . THR B 1 216 ? 0.870 -25.217 -20.232 1.00 19.06 ? 200 THR B CG2 1 ATOM 4422 N N . MET B 1 217 ? 3.540 -24.037 -16.508 1.00 16.75 ? 201 MET B N 1 ATOM 4423 C CA . MET B 1 217 ? 3.754 -23.564 -15.146 1.00 20.76 ? 201 MET B CA 1 ATOM 4424 C C . MET B 1 217 ? 3.976 -22.069 -15.146 1.00 21.84 ? 201 MET B C 1 ATOM 4425 O O . MET B 1 217 ? 4.850 -21.565 -15.840 1.00 25.35 ? 201 MET B O 1 ATOM 4426 C CB . MET B 1 217 ? 4.951 -24.263 -14.483 1.00 22.87 ? 201 MET B CB 1 ATOM 4427 C CG . MET B 1 217 ? 5.128 -23.899 -12.991 1.00 19.55 ? 201 MET B CG 1 ATOM 4428 S SD . MET B 1 217 ? 6.507 -24.679 -12.166 1.00 20.42 ? 201 MET B SD 1 ATOM 4429 C CE . MET B 1 217 ? 7.853 -24.250 -13.261 1.00 20.84 ? 201 MET B CE 1 ATOM 4430 N N . GLU B 1 218 ? 3.205 -21.362 -14.337 1.00 25.48 ? 202 GLU B N 1 ATOM 4431 C CA . GLU B 1 218 ? 3.180 -19.912 -14.415 1.00 32.88 ? 202 GLU B CA 1 ATOM 4432 C C . GLU B 1 218 ? 2.881 -19.561 -15.863 1.00 29.78 ? 202 GLU B C 1 ATOM 4433 O O . GLU B 1 218 ? 1.804 -19.881 -16.359 1.00 37.34 ? 202 GLU B O 1 ATOM 4434 C CB . GLU B 1 218 ? 4.493 -19.298 -13.923 1.00 30.23 ? 202 GLU B CB 1 ATOM 4435 C CG . GLU B 1 218 ? 4.606 -19.247 -12.397 1.00 33.45 ? 202 GLU B CG 1 ATOM 4436 C CD . GLU B 1 218 ? 4.029 -17.975 -11.801 1.00 41.30 ? 202 GLU B CD 1 ATOM 4437 O OE1 . GLU B 1 218 ? 4.773 -16.972 -11.712 1.00 47.00 ? 202 GLU B OE1 1 ATOM 4438 O OE2 . GLU B 1 218 ? 2.842 -17.980 -11.407 1.00 46.46 ? 202 GLU B OE2 1 ATOM 4439 N N . LYS B 1 219 ? 3.819 -18.957 -16.569 1.00 23.63 ? 203 LYS B N 1 ATOM 4440 C CA . LYS B 1 219 ? 3.494 -18.495 -17.903 1.00 27.65 ? 203 LYS B CA 1 ATOM 4441 C C . LYS B 1 219 ? 4.406 -19.117 -18.971 1.00 26.08 ? 203 LYS B C 1 ATOM 4442 O O . LYS B 1 219 ? 4.645 -18.530 -20.020 1.00 30.92 ? 203 LYS B O 1 ATOM 4443 C CB . LYS B 1 219 ? 3.527 -16.963 -17.924 1.00 36.00 ? 203 LYS B CB 1 ATOM 4444 C CG . LYS B 1 219 ? 3.911 -16.349 -16.571 1.00 38.93 ? 203 LYS B CG 1 ATOM 4445 C CD . LYS B 1 219 ? 4.088 -14.830 -16.635 1.00 33.63 ? 203 LYS B CD 1 ATOM 4446 C CE . LYS B 1 219 ? 5.061 -14.312 -15.555 1.00 37.50 ? 203 LYS B CE 1 ATOM 4447 N NZ . LYS B 1 219 ? 4.630 -14.525 -14.129 1.00 38.27 ? 203 LYS B NZ 1 ATOM 4448 N N . LYS B 1 220 ? 4.899 -20.320 -18.701 1.00 26.04 ? 204 LYS B N 1 ATOM 4449 C CA . LYS B 1 220 ? 5.735 -21.040 -19.656 1.00 22.15 ? 204 LYS B CA 1 ATOM 4450 C C . LYS B 1 220 ? 5.283 -22.495 -19.807 1.00 18.28 ? 204 LYS B C 1 ATOM 4451 O O . LYS B 1 220 ? 4.569 -23.022 -18.957 1.00 17.30 ? 204 LYS B O 1 ATOM 4452 C CB . LYS B 1 220 ? 7.199 -20.982 -19.223 1.00 25.70 ? 204 LYS B CB 1 ATOM 4453 C CG . LYS B 1 220 ? 7.916 -19.678 -19.588 1.00 30.73 ? 204 LYS B CG 1 ATOM 4454 C CD . LYS B 1 220 ? 9.384 -19.714 -19.156 1.00 37.77 ? 204 LYS B CD 1 ATOM 4455 C CE . LYS B 1 220 ? 10.194 -18.500 -19.657 1.00 49.94 ? 204 LYS B CE 1 ATOM 4456 N NZ . LYS B 1 220 ? 10.675 -18.646 -21.068 1.00 47.70 ? 204 LYS B NZ 1 ATOM 4457 N N . SER B 1 221 ? 5.700 -23.131 -20.903 1.00 19.92 ? 205 SER B N 1 ATOM 4458 C CA . SER B 1 221 ? 5.337 -24.520 -21.196 1.00 18.60 ? 205 SER B CA 1 ATOM 4459 C C . SER B 1 221 ? 6.516 -25.379 -21.648 1.00 14.85 ? 205 SER B C 1 ATOM 4460 O O . SER B 1 221 ? 7.468 -24.868 -22.204 1.00 19.06 ? 205 SER B O 1 ATOM 4461 C CB . SER B 1 221 ? 4.244 -24.559 -22.247 1.00 17.15 ? 205 SER B CB 1 ATOM 4462 O OG . SER B 1 221 ? 3.048 -24.054 -21.703 1.00 24.62 ? 205 SER B OG 1 ATOM 4463 N N . TRP B 1 222 ? 6.432 -26.682 -21.392 1.00 13.17 ? 206 TRP B N 1 ATOM 4464 C CA . TRP B 1 222 ? 7.463 -27.652 -21.755 1.00 11.24 ? 206 TRP B CA 1 ATOM 4465 C C . TRP B 1 222 ? 6.808 -28.911 -22.345 1.00 14.23 ? 206 TRP B C 1 ATOM 4466 O O . TRP B 1 222 ? 5.627 -29.159 -22.131 1.00 13.34 ? 206 TRP B O 1 ATOM 4467 C CB . TRP B 1 222 ? 8.277 -28.052 -20.519 1.00 12.90 ? 206 TRP B CB 1 ATOM 4468 C CG . TRP B 1 222 ? 9.275 -27.031 -20.041 1.00 16.57 ? 206 TRP B CG 1 ATOM 4469 C CD1 . TRP B 1 222 ? 10.611 -26.990 -20.333 1.00 17.27 ? 206 TRP B CD1 1 ATOM 4470 C CD2 . TRP B 1 222 ? 9.016 -25.917 -19.174 1.00 14.21 ? 206 TRP B CD2 1 ATOM 4471 N NE1 . TRP B 1 222 ? 11.196 -25.919 -19.702 1.00 17.74 ? 206 TRP B NE1 1 ATOM 4472 C CE2 . TRP B 1 222 ? 10.243 -25.238 -18.994 1.00 18.19 ? 206 TRP B CE2 1 ATOM 4473 C CE3 . TRP B 1 222 ? 7.877 -25.414 -18.539 1.00 17.21 ? 206 TRP B CE3 1 ATOM 4474 C CZ2 . TRP B 1 222 ? 10.354 -24.089 -18.205 1.00 23.32 ? 206 TRP B CZ2 1 ATOM 4475 C CZ3 . TRP B 1 222 ? 7.987 -24.271 -17.753 1.00 19.43 ? 206 TRP B CZ3 1 ATOM 4476 C CH2 . TRP B 1 222 ? 9.223 -23.624 -17.597 1.00 24.57 ? 206 TRP B CH2 1 ATOM 4477 N N . LEU B 1 223 ? 7.568 -29.707 -23.087 1.00 13.11 ? 207 LEU B N 1 ATOM 4478 C CA . LEU B 1 223 ? 7.169 -31.074 -23.388 1.00 12.47 ? 207 LEU B CA 1 ATOM 4479 C C . LEU B 1 223 ? 7.894 -32.001 -22.434 1.00 8.14 ? 207 LEU B C 1 ATOM 4480 O O . LEU B 1 223 ? 9.110 -31.942 -22.321 1.00 12.33 ? 207 LEU B O 1 ATOM 4481 C CB . LEU B 1 223 ? 7.545 -31.478 -24.807 1.00 14.07 ? 207 LEU B CB 1 ATOM 4482 C CG . LEU B 1 223 ? 6.829 -30.971 -26.056 1.00 18.04 ? 207 LEU B CG 1 ATOM 4483 C CD1 . LEU B 1 223 ? 5.459 -30.399 -25.789 1.00 15.76 ? 207 LEU B CD1 1 ATOM 4484 C CD2 . LEU B 1 223 ? 7.736 -29.976 -26.748 1.00 20.37 ? 207 LEU B CD2 1 ATOM 4485 N N . VAL B 1 224 ? 7.152 -32.866 -21.750 1.00 9.29 ? 208 VAL B N 1 ATOM 4486 C CA . VAL B 1 224 ? 7.744 -33.782 -20.790 1.00 8.00 ? 208 VAL B CA 1 ATOM 4487 C C . VAL B 1 224 ? 7.210 -35.175 -21.015 1.00 6.59 ? 208 VAL B C 1 ATOM 4488 O O . VAL B 1 224 ? 6.174 -35.343 -21.615 1.00 10.33 ? 208 VAL B O 1 ATOM 4489 C CB . VAL B 1 224 ? 7.454 -33.358 -19.334 1.00 7.35 ? 208 VAL B CB 1 ATOM 4490 C CG1 . VAL B 1 224 ? 8.004 -31.952 -19.064 1.00 8.75 ? 208 VAL B CG1 1 ATOM 4491 C CG2 . VAL B 1 224 ? 5.973 -33.418 -19.050 1.00 5.58 ? 208 VAL B CG2 1 ATOM 4492 N N . HIS B 1 225 ? 7.925 -36.171 -20.538 1.00 5.55 ? 209 HIS B N 1 ATOM 4493 C CA . HIS B 1 225 ? 7.458 -37.527 -20.632 1.00 5.78 ? 209 HIS B CA 1 ATOM 4494 C C . HIS B 1 225 ? 6.347 -37.742 -19.641 1.00 6.38 ? 209 HIS B C 1 ATOM 4495 O O . HIS B 1 225 ? 6.414 -37.264 -18.517 1.00 7.25 ? 209 HIS B O 1 ATOM 4496 C CB . HIS B 1 225 ? 8.604 -38.483 -20.359 1.00 8.96 ? 209 HIS B CB 1 ATOM 4497 C CG . HIS B 1 225 ? 9.552 -38.579 -21.483 1.00 7.59 ? 209 HIS B CG 1 ATOM 4498 N ND1 . HIS B 1 225 ? 9.613 -39.681 -22.334 1.00 10.54 ? 209 HIS B ND1 1 ATOM 4499 C CD2 . HIS B 1 225 ? 10.464 -37.713 -21.986 1.00 8.78 ? 209 HIS B CD2 1 ATOM 4500 C CE1 . HIS B 1 225 ? 10.508 -39.491 -23.246 1.00 11.92 ? 209 HIS B CE1 1 ATOM 4501 N NE2 . HIS B 1 225 ? 11.065 -38.282 -23.064 1.00 11.35 ? 209 HIS B NE2 1 ATOM 4502 N N . LYS B 1 226 ? 5.338 -38.485 -20.074 1.00 6.41 ? 210 LYS B N 1 ATOM 4503 C CA . LYS B 1 226 ? 4.152 -38.755 -19.278 1.00 8.39 ? 210 LYS B CA 1 ATOM 4504 C C . LYS B 1 226 ? 4.488 -39.376 -17.920 1.00 7.97 ? 210 LYS B C 1 ATOM 4505 O O . LYS B 1 226 ? 3.980 -38.941 -16.900 1.00 8.09 ? 210 LYS B O 1 ATOM 4506 C CB . LYS B 1 226 ? 3.197 -39.680 -20.047 1.00 9.53 ? 210 LYS B CB 1 ATOM 4507 C CG . LYS B 1 226 ? 1.827 -39.839 -19.411 1.00 13.11 ? 210 LYS B CG 1 ATOM 4508 C CD . LYS B 1 226 ? 0.954 -40.827 -20.189 1.00 17.68 ? 210 LYS B CD 1 ATOM 4509 C CE . LYS B 1 226 ? 0.869 -40.450 -21.654 1.00 22.24 ? 210 LYS B CE 1 ATOM 4510 N NZ . LYS B 1 226 ? -0.275 -41.102 -22.354 1.00 24.76 ? 210 LYS B NZ 1 ATOM 4511 N N . GLN B 1 227 ? 5.339 -40.388 -17.888 1.00 8.31 ? 211 GLN B N 1 ATOM 4512 C CA . GLN B 1 227 ? 5.578 -41.065 -16.635 1.00 9.82 ? 211 GLN B CA 1 ATOM 4513 C C . GLN B 1 227 ? 6.426 -40.197 -15.716 1.00 9.94 ? 211 GLN B C 1 ATOM 4514 O O . GLN B 1 227 ? 6.243 -40.193 -14.495 1.00 9.97 ? 211 GLN B O 1 ATOM 4515 C CB . GLN B 1 227 ? 6.229 -42.432 -16.853 1.00 10.88 ? 211 GLN B CB 1 ATOM 4516 C CG . GLN B 1 227 ? 6.030 -43.399 -15.692 1.00 11.49 ? 211 GLN B CG 1 ATOM 4517 C CD . GLN B 1 227 ? 4.581 -43.710 -15.460 1.00 14.78 ? 211 GLN B CD 1 ATOM 4518 O OE1 . GLN B 1 227 ? 3.855 -44.041 -16.390 1.00 16.74 ? 211 GLN B OE1 1 ATOM 4519 N NE2 . GLN B 1 227 ? 4.134 -43.564 -14.221 1.00 16.15 ? 211 GLN B NE2 1 ATOM 4520 N N . TRP B 1 228 ? 7.361 -39.465 -16.297 1.00 7.42 ? 212 TRP B N 1 ATOM 4521 C CA . TRP B 1 228 ? 8.125 -38.518 -15.525 1.00 9.98 ? 212 TRP B CA 1 ATOM 4522 C C . TRP B 1 228 ? 7.166 -37.587 -14.786 1.00 8.71 ? 212 TRP B C 1 ATOM 4523 O O . TRP B 1 228 ? 7.335 -37.328 -13.605 1.00 11.63 ? 212 TRP B O 1 ATOM 4524 C CB . TRP B 1 228 ? 9.046 -37.735 -16.449 1.00 9.41 ? 212 TRP B CB 1 ATOM 4525 C CG . TRP B 1 228 ? 9.905 -36.745 -15.766 1.00 8.55 ? 212 TRP B CG 1 ATOM 4526 C CD1 . TRP B 1 228 ? 11.140 -36.955 -15.263 1.00 9.14 ? 212 TRP B CD1 1 ATOM 4527 C CD2 . TRP B 1 228 ? 9.607 -35.365 -15.530 1.00 10.40 ? 212 TRP B CD2 1 ATOM 4528 N NE1 . TRP B 1 228 ? 11.634 -35.803 -14.713 1.00 9.37 ? 212 TRP B NE1 1 ATOM 4529 C CE2 . TRP B 1 228 ? 10.709 -34.811 -14.868 1.00 11.50 ? 212 TRP B CE2 1 ATOM 4530 C CE3 . TRP B 1 228 ? 8.498 -34.564 -15.803 1.00 7.72 ? 212 TRP B CE3 1 ATOM 4531 C CZ2 . TRP B 1 228 ? 10.750 -33.476 -14.471 1.00 10.22 ? 212 TRP B CZ2 1 ATOM 4532 C CZ3 . TRP B 1 228 ? 8.543 -33.238 -15.404 1.00 11.63 ? 212 TRP B CZ3 1 ATOM 4533 C CH2 . TRP B 1 228 ? 9.662 -32.711 -14.741 1.00 10.91 ? 212 TRP B CH2 1 ATOM 4534 N N . PHE B 1 229 ? 6.155 -37.092 -15.488 1.00 8.46 ? 213 PHE B N 1 ATOM 4535 C CA . PHE B 1 229 ? 5.143 -36.222 -14.898 1.00 8.26 ? 213 PHE B CA 1 ATOM 4536 C C . PHE B 1 229 ? 4.235 -36.921 -13.877 1.00 8.07 ? 213 PHE B C 1 ATOM 4537 O O . PHE B 1 229 ? 3.963 -36.363 -12.827 1.00 10.80 ? 213 PHE B O 1 ATOM 4538 C CB . PHE B 1 229 ? 4.298 -35.599 -16.011 1.00 7.80 ? 213 PHE B CB 1 ATOM 4539 C CG . PHE B 1 229 ? 3.078 -34.888 -15.522 1.00 7.31 ? 213 PHE B CG 1 ATOM 4540 C CD1 . PHE B 1 229 ? 3.162 -33.616 -15.006 1.00 8.99 ? 213 PHE B CD1 1 ATOM 4541 C CD2 . PHE B 1 229 ? 1.836 -35.489 -15.592 1.00 9.84 ? 213 PHE B CD2 1 ATOM 4542 C CE1 . PHE B 1 229 ? 2.026 -32.951 -14.534 1.00 9.95 ? 213 PHE B CE1 1 ATOM 4543 C CE2 . PHE B 1 229 ? 0.695 -34.832 -15.120 1.00 11.22 ? 213 PHE B CE2 1 ATOM 4544 C CZ . PHE B 1 229 ? 0.799 -33.561 -14.597 1.00 8.98 ? 213 PHE B CZ 1 ATOM 4545 N N . LEU B 1 230 ? 3.785 -38.137 -14.180 1.00 8.17 ? 214 LEU B N 1 ATOM 4546 C CA . LEU B 1 230 ? 2.886 -38.872 -13.298 1.00 11.07 ? 214 LEU B CA 1 ATOM 4547 C C . LEU B 1 230 ? 3.563 -39.298 -11.991 1.00 12.96 ? 214 LEU B C 1 ATOM 4548 O O . LEU B 1 230 ? 2.902 -39.548 -10.977 1.00 12.96 ? 214 LEU B O 1 ATOM 4549 C CB . LEU B 1 230 ? 2.326 -40.106 -14.025 1.00 10.00 ? 214 LEU B CB 1 ATOM 4550 C CG . LEU B 1 230 ? 1.277 -39.898 -15.115 1.00 10.32 ? 214 LEU B CG 1 ATOM 4551 C CD1 . LEU B 1 230 ? 0.896 -41.220 -15.705 1.00 11.23 ? 214 LEU B CD1 1 ATOM 4552 C CD2 . LEU B 1 230 ? 0.052 -39.190 -14.577 1.00 10.22 ? 214 LEU B CD2 1 ATOM 4553 N N . ASP B 1 231 ? 4.884 -39.380 -12.013 1.00 11.92 ? 215 ASP B N 1 ATOM 4554 C CA . ASP B 1 231 ? 5.618 -39.860 -10.860 1.00 14.54 ? 215 ASP B CA 1 ATOM 4555 C C . ASP B 1 231 ? 6.295 -38.753 -10.050 1.00 13.43 ? 215 ASP B C 1 ATOM 4556 O O . ASP B 1 231 ? 7.039 -39.047 -9.133 1.00 15.82 ? 215 ASP B O 1 ATOM 4557 C CB . ASP B 1 231 ? 6.653 -40.889 -11.296 1.00 14.71 ? 215 ASP B CB 1 ATOM 4558 C CG . ASP B 1 231 ? 6.044 -42.249 -11.542 1.00 17.24 ? 215 ASP B CG 1 ATOM 4559 O OD1 . ASP B 1 231 ? 4.926 -42.493 -11.051 1.00 23.03 ? 215 ASP B OD1 1 ATOM 4560 O OD2 . ASP B 1 231 ? 6.684 -43.075 -12.217 1.00 18.49 ? 215 ASP B OD2 1 ATOM 4561 N N . LEU B 1 232 ? 6.041 -37.487 -10.378 1.00 14.78 ? 216 LEU B N 1 ATOM 4562 C CA . LEU B 1 232 ? 6.617 -36.362 -9.633 1.00 13.89 ? 216 LEU B CA 1 ATOM 4563 C C . LEU B 1 232 ? 6.044 -36.321 -8.214 1.00 19.77 ? 216 LEU B C 1 ATOM 4564 O O . LEU B 1 232 ? 4.848 -36.515 -8.024 1.00 17.53 ? 216 LEU B O 1 ATOM 4565 C CB . LEU B 1 232 ? 6.343 -35.026 -10.333 1.00 15.20 ? 216 LEU B CB 1 ATOM 4566 C CG . LEU B 1 232 ? 7.299 -34.553 -11.429 1.00 12.04 ? 216 LEU B CG 1 ATOM 4567 C CD1 . LEU B 1 232 ? 6.683 -33.375 -12.153 1.00 14.95 ? 216 LEU B CD1 1 ATOM 4568 C CD2 . LEU B 1 232 ? 8.629 -34.174 -10.844 1.00 12.46 ? 216 LEU B CD2 1 ATOM 4569 N N . PRO B 1 233 ? 6.904 -36.073 -7.214 1.00 16.25 ? 217 PRO B N 1 ATOM 4570 C CA . PRO B 1 233 ? 6.506 -36.089 -5.804 1.00 20.20 ? 217 PRO B CA 1 ATOM 4571 C C . PRO B 1 233 ? 5.956 -34.746 -5.322 1.00 20.56 ? 217 PRO B C 1 ATOM 4572 O O . PRO B 1 233 ? 6.547 -34.110 -4.441 1.00 21.60 ? 217 PRO B O 1 ATOM 4573 C CB . PRO B 1 233 ? 7.818 -36.418 -5.091 1.00 18.65 ? 217 PRO B CB 1 ATOM 4574 C CG . PRO B 1 233 ? 8.855 -35.811 -5.943 1.00 19.98 ? 217 PRO B CG 1 ATOM 4575 C CD . PRO B 1 233 ? 8.354 -35.866 -7.361 1.00 17.29 ? 217 PRO B CD 1 ATOM 4576 N N . LEU B 1 234 ? 4.819 -34.350 -5.887 1.00 15.65 ? 218 LEU B N 1 ATOM 4577 C CA . LEU B 1 234 ? 4.097 -33.156 -5.482 1.00 15.91 ? 218 LEU B CA 1 ATOM 4578 C C . LEU B 1 234 ? 2.630 -33.513 -5.178 1.00 17.66 ? 218 LEU B C 1 ATOM 4579 O O . LEU B 1 234 ? 2.129 -34.528 -5.671 1.00 17.23 ? 218 LEU B O 1 ATOM 4580 C CB . LEU B 1 234 ? 4.155 -32.123 -6.600 1.00 16.53 ? 218 LEU B CB 1 ATOM 4581 C CG . LEU B 1 234 ? 5.509 -31.464 -6.849 1.00 16.61 ? 218 LEU B CG 1 ATOM 4582 C CD1 . LEU B 1 234 ? 5.444 -30.653 -8.118 1.00 17.90 ? 218 LEU B CD1 1 ATOM 4583 C CD2 . LEU B 1 234 ? 5.912 -30.592 -5.678 1.00 17.23 ? 218 LEU B CD2 1 ATOM 4584 N N . PRO B 1 235 ? 1.943 -32.693 -4.353 1.00 15.01 ? 219 PRO B N 1 ATOM 4585 C CA . PRO B 1 235 ? 0.496 -32.870 -4.152 1.00 14.17 ? 219 PRO B CA 1 ATOM 4586 C C . PRO B 1 235 ? -0.298 -32.752 -5.473 1.00 13.01 ? 219 PRO B C 1 ATOM 4587 O O . PRO B 1 235 ? -0.028 -31.862 -6.270 1.00 13.98 ? 219 PRO B O 1 ATOM 4588 C CB . PRO B 1 235 ? 0.127 -31.725 -3.195 1.00 14.80 ? 219 PRO B CB 1 ATOM 4589 C CG . PRO B 1 235 ? 1.394 -31.293 -2.575 1.00 16.00 ? 219 PRO B CG 1 ATOM 4590 C CD . PRO B 1 235 ? 2.485 -31.580 -3.552 1.00 12.71 ? 219 PRO B CD 1 ATOM 4591 N N . TRP B 1 236 ? -1.283 -33.612 -5.704 1.00 12.82 ? 220 TRP B N 1 ATOM 4592 C CA . TRP B 1 236 ? -1.966 -33.600 -6.995 1.00 12.89 ? 220 TRP B CA 1 ATOM 4593 C C . TRP B 1 236 ? -3.485 -33.652 -6.954 1.00 12.09 ? 220 TRP B C 1 ATOM 4594 O O . TRP B 1 236 ? -4.085 -34.087 -5.998 1.00 13.11 ? 220 TRP B O 1 ATOM 4595 C CB . TRP B 1 236 ? -1.448 -34.744 -7.889 1.00 12.75 ? 220 TRP B CB 1 ATOM 4596 C CG . TRP B 1 236 ? -1.757 -36.148 -7.420 1.00 14.75 ? 220 TRP B CG 1 ATOM 4597 C CD1 . TRP B 1 236 ? -1.041 -36.888 -6.533 1.00 15.05 ? 220 TRP B CD1 1 ATOM 4598 C CD2 . TRP B 1 236 ? -2.845 -36.983 -7.849 1.00 15.03 ? 220 TRP B CD2 1 ATOM 4599 N NE1 . TRP B 1 236 ? -1.620 -38.122 -6.367 1.00 17.56 ? 220 TRP B NE1 1 ATOM 4600 C CE2 . TRP B 1 236 ? -2.732 -38.204 -7.161 1.00 17.74 ? 220 TRP B CE2 1 ATOM 4601 C CE3 . TRP B 1 236 ? -3.912 -36.808 -8.740 1.00 12.86 ? 220 TRP B CE3 1 ATOM 4602 C CZ2 . TRP B 1 236 ? -3.639 -39.249 -7.338 1.00 15.75 ? 220 TRP B CZ2 1 ATOM 4603 C CZ3 . TRP B 1 236 ? -4.808 -37.837 -8.909 1.00 13.34 ? 220 TRP B CZ3 1 ATOM 4604 C CH2 . TRP B 1 236 ? -4.664 -39.045 -8.215 1.00 14.70 ? 220 TRP B CH2 1 ATOM 4605 N N . THR B 1 237 ? -4.111 -33.204 -8.029 1.00 12.17 ? 221 THR B N 1 ATOM 4606 C CA . THR B 1 237 ? -5.507 -33.499 -8.233 1.00 12.81 ? 221 THR B CA 1 ATOM 4607 C C . THR B 1 237 ? -5.778 -33.818 -9.692 1.00 12.72 ? 221 THR B C 1 ATOM 4608 O O . THR B 1 237 ? -5.030 -33.420 -10.570 1.00 11.80 ? 221 THR B O 1 ATOM 4609 C CB . THR B 1 237 ? -6.405 -32.347 -7.788 1.00 17.73 ? 221 THR B CB 1 ATOM 4610 O OG1 . THR B 1 237 ? -7.774 -32.716 -7.993 1.00 18.33 ? 221 THR B OG1 1 ATOM 4611 C CG2 . THR B 1 237 ? -6.088 -31.087 -8.573 1.00 17.53 ? 221 THR B CG2 1 ATOM 4612 N N . SER B 1 238 ? -6.868 -34.529 -9.939 1.00 13.14 ? 222 SER B N 1 ATOM 4613 C CA . SER B 1 238 ? -7.235 -34.927 -11.285 1.00 13.35 ? 222 SER B CA 1 ATOM 4614 C C . SER B 1 238 ? -7.601 -33.743 -12.174 1.00 9.59 ? 222 SER B C 1 ATOM 4615 O O . SER B 1 238 ? -7.952 -32.679 -11.692 1.00 8.49 ? 222 SER B O 1 ATOM 4616 C CB . SER B 1 238 ? -8.394 -35.916 -11.212 1.00 11.39 ? 222 SER B CB 1 ATOM 4617 O OG . SER B 1 238 ? -8.693 -36.428 -12.483 1.00 14.08 ? 222 SER B OG 1 ATOM 4618 N N . GLY B 1 239 ? -7.484 -33.936 -13.484 1.00 8.84 ? 223 GLY B N 1 ATOM 4619 C CA . GLY B 1 239 ? -7.929 -32.941 -14.423 1.00 8.19 ? 223 GLY B CA 1 ATOM 4620 C C . GLY B 1 239 ? -9.427 -32.965 -14.591 1.00 9.07 ? 223 GLY B C 1 ATOM 4621 O O . GLY B 1 239 ? -9.989 -32.000 -15.080 1.00 11.31 ? 223 GLY B O 1 ATOM 4622 N N . ALA B 1 240 ? -10.064 -34.058 -14.172 1.00 8.51 ? 224 ALA B N 1 ATOM 4623 C CA . ALA B 1 240 ? -11.494 -34.262 -14.356 1.00 8.43 ? 224 ALA B CA 1 ATOM 4624 C C . ALA B 1 240 ? -12.293 -33.115 -13.727 1.00 11.88 ? 224 ALA B C 1 ATOM 4625 O O . ALA B 1 240 ? -11.852 -32.485 -12.769 1.00 13.68 ? 224 ALA B O 1 ATOM 4626 C CB . ALA B 1 240 ? -11.883 -35.545 -13.771 1.00 7.45 ? 224 ALA B CB 1 ATOM 4627 N N . SER B 1 241 ? -13.472 -32.838 -14.268 1.00 14.30 ? 225 SER B N 1 ATOM 4628 C CA . SER B 1 241 ? -14.167 -31.606 -13.918 1.00 14.95 ? 225 SER B CA 1 ATOM 4629 C C . SER B 1 241 ? -14.859 -31.710 -12.563 1.00 17.82 ? 225 SER B C 1 ATOM 4630 O O . SER B 1 241 ? -15.337 -32.781 -12.180 1.00 17.42 ? 225 SER B O 1 ATOM 4631 C CB . SER B 1 241 ? -15.160 -31.206 -15.018 1.00 14.96 ? 225 SER B CB 1 ATOM 4632 O OG . SER B 1 241 ? -15.894 -32.321 -15.483 1.00 15.50 ? 225 SER B OG 1 ATOM 4633 N N . THR B 1 242 ? -14.894 -30.584 -11.848 1.00 15.97 ? 226 THR B N 1 ATOM 4634 C CA . THR B 1 242 ? -15.443 -30.536 -10.506 1.00 20.26 ? 226 THR B CA 1 ATOM 4635 C C . THR B 1 242 ? -15.576 -29.097 -10.019 1.00 22.20 ? 226 THR B C 1 ATOM 4636 O O . THR B 1 242 ? -14.949 -28.196 -10.570 1.00 22.07 ? 226 THR B O 1 ATOM 4637 C CB . THR B 1 242 ? -14.523 -31.288 -9.539 1.00 22.48 ? 226 THR B CB 1 ATOM 4638 O OG1 . THR B 1 242 ? -15.038 -31.205 -8.205 1.00 23.40 ? 226 THR B OG1 1 ATOM 4639 C CG2 . THR B 1 242 ? -13.130 -30.692 -9.586 1.00 21.26 ? 226 THR B CG2 1 ATOM 4640 N N . SER B 1 243 ? -16.387 -28.896 -8.981 1.00 23.23 ? 227 SER B N 1 ATOM 4641 C CA . SER B 1 243 ? -16.522 -27.589 -8.343 1.00 27.30 ? 227 SER B CA 1 ATOM 4642 C C . SER B 1 243 ? -15.167 -27.113 -7.854 1.00 35.19 ? 227 SER B C 1 ATOM 4643 O O . SER B 1 243 ? -14.516 -26.307 -8.522 1.00 41.53 ? 227 SER B O 1 ATOM 4644 C CB . SER B 1 243 ? -17.473 -27.657 -7.147 1.00 27.50 ? 227 SER B CB 1 ATOM 4645 O OG . SER B 1 243 ? -17.224 -28.833 -6.399 1.00 34.18 ? 227 SER B OG 1 ATOM 4646 N N . GLN B 1 244 ? -14.735 -27.632 -6.700 1.00 34.16 ? 228 GLN B N 1 ATOM 4647 C CA . GLN B 1 244 ? -13.524 -27.139 -6.026 1.00 30.66 ? 228 GLN B CA 1 ATOM 4648 C C . GLN B 1 244 ? -12.333 -28.096 -6.057 1.00 28.30 ? 228 GLN B C 1 ATOM 4649 O O . GLN B 1 244 ? -12.502 -29.305 -6.185 1.00 23.73 ? 228 GLN B O 1 ATOM 4650 C CB . GLN B 1 244 ? -13.827 -26.826 -4.564 1.00 36.28 ? 228 GLN B CB 1 ATOM 4651 C CG . GLN B 1 244 ? -14.248 -28.041 -3.760 1.00 35.70 ? 228 GLN B CG 1 ATOM 4652 C CD . GLN B 1 244 ? -14.160 -27.792 -2.280 1.00 33.26 ? 228 GLN B CD 1 ATOM 4653 O OE1 . GLN B 1 244 ? -14.037 -26.651 -1.851 1.00 38.08 ? 228 GLN B OE1 1 ATOM 4654 N NE2 . GLN B 1 244 ? -14.223 -28.852 -1.489 1.00 32.24 ? 228 GLN B NE2 1 ATOM 4655 N N . GLU B 1 245 ? -11.133 -27.525 -5.903 1.00 37.34 ? 229 GLU B N 1 ATOM 4656 C CA . GLU B 1 245 ? -9.863 -28.265 -5.801 1.00 36.38 ? 229 GLU B CA 1 ATOM 4657 C C . GLU B 1 245 ? -9.851 -29.306 -4.668 1.00 30.32 ? 229 GLU B C 1 ATOM 4658 O O . GLU B 1 245 ? -10.158 -28.993 -3.521 1.00 32.07 ? 229 GLU B O 1 ATOM 4659 C CB . GLU B 1 245 ? -8.692 -27.280 -5.553 1.00 34.30 ? 229 GLU B CB 1 ATOM 4660 C CG . GLU B 1 245 ? -8.205 -26.455 -6.759 1.00 31.23 ? 229 GLU B CG 1 ATOM 4661 C CD . GLU B 1 245 ? -7.219 -25.330 -6.381 1.00 33.23 ? 229 GLU B CD 1 ATOM 4662 O OE1 . GLU B 1 245 ? -6.591 -24.756 -7.293 1.00 43.73 ? 229 GLU B OE1 1 ATOM 4663 O OE2 . GLU B 1 245 ? -7.068 -25.006 -5.185 1.00 39.30 ? 229 GLU B OE2 1 ATOM 4664 N N . THR B 1 246 ? -9.451 -30.532 -4.988 1.00 32.66 ? 230 THR B N 1 ATOM 4665 C CA . THR B 1 246 ? -9.297 -31.587 -3.983 1.00 32.28 ? 230 THR B CA 1 ATOM 4666 C C . THR B 1 246 ? -7.928 -32.279 -4.097 1.00 24.19 ? 230 THR B C 1 ATOM 4667 O O . THR B 1 246 ? -7.757 -33.169 -4.935 1.00 25.62 ? 230 THR B O 1 ATOM 4668 C CB . THR B 1 246 ? -10.356 -32.652 -4.167 1.00 34.89 ? 230 THR B CB 1 ATOM 4669 O OG1 . THR B 1 246 ? -9.715 -33.882 -4.530 1.00 41.35 ? 230 THR B OG1 1 ATOM 4670 C CG2 . THR B 1 246 ? -11.333 -32.240 -5.268 1.00 37.29 ? 230 THR B CG2 1 ATOM 4671 N N . TRP B 1 247 ? -6.979 -31.881 -3.243 1.00 21.71 ? 231 TRP B N 1 ATOM 4672 C CA . TRP B 1 247 ? -5.572 -32.286 -3.348 1.00 15.07 ? 231 TRP B CA 1 ATOM 4673 C C . TRP B 1 247 ? -5.259 -33.622 -2.739 1.00 15.22 ? 231 TRP B C 1 ATOM 4674 O O . TRP B 1 247 ? -5.785 -33.980 -1.705 1.00 19.74 ? 231 TRP B O 1 ATOM 4675 C CB . TRP B 1 247 ? -4.674 -31.233 -2.717 1.00 13.69 ? 231 TRP B CB 1 ATOM 4676 C CG . TRP B 1 247 ? -4.775 -29.991 -3.452 1.00 14.94 ? 231 TRP B CG 1 ATOM 4677 C CD1 . TRP B 1 247 ? -5.526 -28.905 -3.132 1.00 19.69 ? 231 TRP B CD1 1 ATOM 4678 C CD2 . TRP B 1 247 ? -4.150 -29.693 -4.699 1.00 17.74 ? 231 TRP B CD2 1 ATOM 4679 N NE1 . TRP B 1 247 ? -5.386 -27.932 -4.095 1.00 22.65 ? 231 TRP B NE1 1 ATOM 4680 C CE2 . TRP B 1 247 ? -4.546 -28.402 -5.075 1.00 19.35 ? 231 TRP B CE2 1 ATOM 4681 C CE3 . TRP B 1 247 ? -3.283 -30.399 -5.538 1.00 14.37 ? 231 TRP B CE3 1 ATOM 4682 C CZ2 . TRP B 1 247 ? -4.104 -27.794 -6.233 1.00 21.34 ? 231 TRP B CZ2 1 ATOM 4683 C CZ3 . TRP B 1 247 ? -2.844 -29.793 -6.689 1.00 13.32 ? 231 TRP B CZ3 1 ATOM 4684 C CH2 . TRP B 1 247 ? -3.261 -28.511 -7.033 1.00 15.01 ? 231 TRP B CH2 1 ATOM 4685 N N . ASN B 1 248 ? -4.401 -34.366 -3.413 1.00 14.50 ? 232 ASN B N 1 ATOM 4686 C CA . ASN B 1 248 ? -3.895 -35.624 -2.904 1.00 16.47 ? 232 ASN B CA 1 ATOM 4687 C C . ASN B 1 248 ? -2.438 -35.406 -2.517 1.00 16.05 ? 232 ASN B C 1 ATOM 4688 O O . ASN B 1 248 ? -1.761 -34.578 -3.109 1.00 15.04 ? 232 ASN B O 1 ATOM 4689 C CB . ASN B 1 248 ? -4.008 -36.723 -3.965 1.00 16.03 ? 232 ASN B CB 1 ATOM 4690 C CG . ASN B 1 248 ? -5.453 -37.051 -4.345 1.00 15.30 ? 232 ASN B CG 1 ATOM 4691 O OD1 . ASN B 1 248 ? -6.326 -37.198 -3.489 1.00 22.49 ? 232 ASN B OD1 1 ATOM 4692 N ND2 . ASN B 1 248 ? -5.699 -37.178 -5.627 1.00 12.23 ? 232 ASN B ND2 1 ATOM 4693 N N . ARG B 1 249 ? -1.976 -36.141 -1.513 1.00 18.99 ? 233 ARG B N 1 ATOM 4694 C CA . ARG B 1 249 ? -0.610 -36.039 -1.003 1.00 23.07 ? 233 ARG B CA 1 ATOM 4695 C C . ARG B 1 249 ? -0.177 -34.621 -0.603 1.00 17.79 ? 233 ARG B C 1 ATOM 4696 O O . ARG B 1 249 ? 0.958 -34.244 -0.833 1.00 17.60 ? 233 ARG B O 1 ATOM 4697 C CB . ARG B 1 249 ? 0.394 -36.599 -2.017 1.00 22.46 ? 233 ARG B CB 1 ATOM 4698 C CG . ARG B 1 249 ? 0.044 -37.955 -2.619 1.00 24.95 ? 233 ARG B CG 1 ATOM 4699 C CD . ARG B 1 249 ? -0.227 -39.008 -1.558 1.00 32.42 ? 233 ARG B CD 1 ATOM 4700 N NE . ARG B 1 249 ? 0.768 -39.048 -0.478 1.00 39.06 ? 233 ARG B NE 1 ATOM 4701 C CZ . ARG B 1 249 ? 2.013 -39.513 -0.596 1.00 37.31 ? 233 ARG B CZ 1 ATOM 4702 N NH1 . ARG B 1 249 ? 2.454 -39.971 -1.766 1.00 36.04 ? 233 ARG B NH1 1 ATOM 4703 N NH2 . ARG B 1 249 ? 2.821 -39.509 0.460 1.00 33.49 ? 233 ARG B NH2 1 ATOM 4704 N N . GLN B 1 250 ? -1.061 -33.840 0.009 1.00 21.89 ? 234 GLN B N 1 ATOM 4705 C CA . GLN B 1 250 ? -0.692 -32.486 0.447 1.00 22.49 ? 234 GLN B CA 1 ATOM 4706 C C . GLN B 1 250 ? 0.479 -32.502 1.428 1.00 24.01 ? 234 GLN B C 1 ATOM 4707 O O . GLN B 1 250 ? 1.220 -31.527 1.544 1.00 23.52 ? 234 GLN B O 1 ATOM 4708 C CB . GLN B 1 250 ? -1.857 -31.784 1.126 1.00 18.87 ? 234 GLN B CB 1 ATOM 4709 C CG . GLN B 1 250 ? -3.140 -31.826 0.372 1.00 19.73 ? 234 GLN B CG 1 ATOM 4710 C CD . GLN B 1 250 ? -4.036 -32.862 0.924 1.00 22.45 ? 234 GLN B CD 1 ATOM 4711 O OE1 . GLN B 1 250 ? -3.767 -34.047 0.780 1.00 25.95 ? 234 GLN B OE1 1 ATOM 4712 N NE2 . GLN B 1 250 ? -5.089 -32.440 1.610 1.00 27.76 ? 234 GLN B NE2 1 ATOM 4713 N N . ASP B 1 251 ? 0.608 -33.611 2.150 1.00 20.28 ? 235 ASP B N 1 ATOM 4714 C CA . ASP B 1 251 ? 1.642 -33.791 3.155 1.00 23.83 ? 235 ASP B CA 1 ATOM 4715 C C . ASP B 1 251 ? 3.010 -33.712 2.526 1.00 21.53 ? 235 ASP B C 1 ATOM 4716 O O . ASP B 1 251 ? 4.024 -33.690 3.218 1.00 24.33 ? 235 ASP B O 1 ATOM 4717 C CB . ASP B 1 251 ? 1.490 -35.162 3.772 1.00 26.98 ? 235 ASP B CB 1 ATOM 4718 C CG . ASP B 1 251 ? 1.351 -36.238 2.717 1.00 31.36 ? 235 ASP B CG 1 ATOM 4719 O OD1 . ASP B 1 251 ? 2.395 -36.761 2.263 1.00 35.46 ? 235 ASP B OD1 1 ATOM 4720 O OD2 . ASP B 1 251 ? 0.204 -36.532 2.311 1.00 31.22 ? 235 ASP B OD2 1 ATOM 4721 N N . LEU B 1 252 ? 3.040 -33.724 1.206 1.00 20.31 ? 236 LEU B N 1 ATOM 4722 C CA . LEU B 1 252 ? 4.274 -33.511 0.493 1.00 20.53 ? 236 LEU B CA 1 ATOM 4723 C C . LEU B 1 252 ? 4.751 -32.078 0.692 1.00 21.16 ? 236 LEU B C 1 ATOM 4724 O O . LEU B 1 252 ? 5.945 -31.826 0.660 1.00 24.61 ? 236 LEU B O 1 ATOM 4725 C CB . LEU B 1 252 ? 4.089 -33.824 -0.988 1.00 18.05 ? 236 LEU B CB 1 ATOM 4726 C CG . LEU B 1 252 ? 3.754 -35.285 -1.290 1.00 19.53 ? 236 LEU B CG 1 ATOM 4727 C CD1 . LEU B 1 252 ? 3.671 -35.563 -2.790 1.00 17.47 ? 236 LEU B CD1 1 ATOM 4728 C CD2 . LEU B 1 252 ? 4.747 -36.202 -0.658 1.00 22.77 ? 236 LEU B CD2 1 ATOM 4729 N N . LEU B 1 253 ? 3.828 -31.148 0.917 1.00 16.62 ? 237 LEU B N 1 ATOM 4730 C CA . LEU B 1 253 ? 4.203 -29.768 1.145 1.00 16.87 ? 237 LEU B CA 1 ATOM 4731 C C . LEU B 1 253 ? 3.856 -29.307 2.555 1.00 22.86 ? 237 LEU B C 1 ATOM 4732 O O . LEU B 1 253 ? 4.203 -28.211 2.949 1.00 25.70 ? 237 LEU B O 1 ATOM 4733 C CB . LEU B 1 253 ? 3.518 -28.857 0.142 1.00 17.77 ? 237 LEU B CB 1 ATOM 4734 C CG . LEU B 1 253 ? 3.822 -29.104 -1.331 1.00 17.09 ? 237 LEU B CG 1 ATOM 4735 C CD1 . LEU B 1 253 ? 3.114 -28.057 -2.153 1.00 15.74 ? 237 LEU B CD1 1 ATOM 4736 C CD2 . LEU B 1 253 ? 5.307 -29.078 -1.597 1.00 20.94 ? 237 LEU B CD2 1 ATOM 4737 N N . VAL B 1 254 ? 3.176 -30.136 3.323 1.00 24.65 ? 238 VAL B N 1 ATOM 4738 C CA . VAL B 1 254 ? 2.775 -29.722 4.650 1.00 22.04 ? 238 VAL B CA 1 ATOM 4739 C C . VAL B 1 254 ? 3.486 -30.531 5.719 1.00 27.14 ? 238 VAL B C 1 ATOM 4740 O O . VAL B 1 254 ? 3.494 -31.766 5.682 1.00 29.18 ? 238 VAL B O 1 ATOM 4741 C CB . VAL B 1 254 ? 1.273 -29.866 4.833 1.00 18.10 ? 238 VAL B CB 1 ATOM 4742 C CG1 . VAL B 1 254 ? 0.879 -29.367 6.180 1.00 22.02 ? 238 VAL B CG1 1 ATOM 4743 C CG2 . VAL B 1 254 ? 0.559 -29.080 3.770 1.00 21.78 ? 238 VAL B CG2 1 ATOM 4744 N N . THR B 1 255 ? 4.068 -29.833 6.688 1.00 28.61 ? 239 THR B N 1 ATOM 4745 C CA . THR B 1 255 ? 4.726 -30.495 7.807 1.00 29.84 ? 239 THR B CA 1 ATOM 4746 C C . THR B 1 255 ? 4.043 -30.151 9.135 1.00 27.58 ? 239 THR B C 1 ATOM 4747 O O . THR B 1 255 ? 3.841 -28.981 9.461 1.00 29.07 ? 239 THR B O 1 ATOM 4748 C CB . THR B 1 255 ? 6.219 -30.124 7.868 1.00 36.04 ? 239 THR B CB 1 ATOM 4749 O OG1 . THR B 1 255 ? 6.811 -30.285 6.569 1.00 39.06 ? 239 THR B OG1 1 ATOM 4750 C CG2 . THR B 1 255 ? 6.942 -30.999 8.874 1.00 33.07 ? 239 THR B CG2 1 ATOM 4751 N N . PHE B 1 256 ? 3.671 -31.190 9.876 1.00 28.44 ? 240 PHE B N 1 ATOM 4752 C CA . PHE B 1 256 ? 3.081 -31.045 11.203 1.00 30.24 ? 240 PHE B CA 1 ATOM 4753 C C . PHE B 1 256 ? 4.204 -31.186 12.208 1.00 33.64 ? 240 PHE B C 1 ATOM 4754 O O . PHE B 1 256 ? 4.786 -32.262 12.348 1.00 31.65 ? 240 PHE B O 1 ATOM 4755 C CB . PHE B 1 256 ? 2.067 -32.157 11.478 1.00 27.41 ? 240 PHE B CB 1 ATOM 4756 C CG . PHE B 1 256 ? 0.764 -32.006 10.747 1.00 28.63 ? 240 PHE B CG 1 ATOM 4757 C CD1 . PHE B 1 256 ? 0.702 -32.118 9.368 1.00 24.57 ? 240 PHE B CD1 1 ATOM 4758 C CD2 . PHE B 1 256 ? -0.410 -31.795 11.447 1.00 29.03 ? 240 PHE B CD2 1 ATOM 4759 C CE1 . PHE B 1 256 ? -0.489 -31.997 8.708 1.00 23.89 ? 240 PHE B CE1 1 ATOM 4760 C CE2 . PHE B 1 256 ? -1.606 -31.660 10.783 1.00 24.10 ? 240 PHE B CE2 1 ATOM 4761 C CZ . PHE B 1 256 ? -1.643 -31.768 9.413 1.00 25.50 ? 240 PHE B CZ 1 ATOM 4762 N N . LYS B 1 257 ? 4.532 -30.116 12.913 1.00 34.26 ? 241 LYS B N 1 ATOM 4763 C CA . LYS B 1 257 ? 5.671 -30.185 13.809 1.00 35.69 ? 241 LYS B CA 1 ATOM 4764 C C . LYS B 1 257 ? 5.281 -30.856 15.117 1.00 38.78 ? 241 LYS B C 1 ATOM 4765 O O . LYS B 1 257 ? 4.096 -31.009 15.415 1.00 35.26 ? 241 LYS B O 1 ATOM 4766 C CB . LYS B 1 257 ? 6.271 -28.797 14.047 1.00 41.75 ? 241 LYS B CB 1 ATOM 4767 C CG . LYS B 1 257 ? 7.675 -28.628 13.445 1.00 51.83 ? 241 LYS B CG 1 ATOM 4768 C CD . LYS B 1 257 ? 8.734 -29.525 14.131 1.00 53.90 ? 241 LYS B CD 1 ATOM 4769 C CE . LYS B 1 257 ? 9.098 -29.045 15.549 1.00 44.53 ? 241 LYS B CE 1 ATOM 4770 N NZ . LYS B 1 257 ? 9.875 -30.056 16.329 1.00 46.29 ? 241 LYS B NZ 1 ATOM 4771 N N . THR B 1 258 ? 6.294 -31.262 15.883 1.00 47.67 ? 242 THR B N 1 ATOM 4772 C CA . THR B 1 258 ? 6.104 -31.941 17.164 1.00 39.37 ? 242 THR B CA 1 ATOM 4773 C C . THR B 1 258 ? 4.967 -31.312 17.960 1.00 30.91 ? 242 THR B C 1 ATOM 4774 O O . THR B 1 258 ? 4.891 -30.100 18.107 1.00 34.31 ? 242 THR B O 1 ATOM 4775 C CB . THR B 1 258 ? 7.409 -31.924 17.999 1.00 40.34 ? 242 THR B CB 1 ATOM 4776 O OG1 . THR B 1 258 ? 7.239 -32.703 19.189 1.00 42.55 ? 242 THR B OG1 1 ATOM 4777 C CG2 . THR B 1 258 ? 7.799 -30.503 18.391 1.00 39.24 ? 242 THR B CG2 1 ATOM 4778 N N . ALA B 1 259 ? 4.072 -32.151 18.461 1.00 27.82 ? 243 ALA B N 1 ATOM 4779 C CA . ALA B 1 259 ? 2.872 -31.674 19.135 1.00 33.15 ? 243 ALA B CA 1 ATOM 4780 C C . ALA B 1 259 ? 3.075 -31.491 20.630 1.00 32.59 ? 243 ALA B C 1 ATOM 4781 O O . ALA B 1 259 ? 3.697 -32.322 21.285 1.00 33.86 ? 243 ALA B O 1 ATOM 4782 C CB . ALA B 1 259 ? 1.725 -32.643 18.896 1.00 32.35 ? 243 ALA B CB 1 ATOM 4783 N N . HIS B 1 260 ? 2.526 -30.407 21.162 1.00 32.03 ? 244 HIS B N 1 ATOM 4784 C CA . HIS B 1 260 ? 2.480 -30.193 22.601 1.00 33.01 ? 244 HIS B CA 1 ATOM 4785 C C . HIS B 1 260 ? 1.064 -30.494 23.062 1.00 37.72 ? 244 HIS B C 1 ATOM 4786 O O . HIS B 1 260 ? 0.171 -30.696 22.242 1.00 36.69 ? 244 HIS B O 1 ATOM 4787 C CB . HIS B 1 260 ? 2.861 -28.773 22.946 1.00 38.51 ? 244 HIS B CB 1 ATOM 4788 N N . ALA B 1 261 ? 0.849 -30.512 24.368 1.00 38.71 ? 245 ALA B N 1 ATOM 4789 C CA . ALA B 1 261 ? -0.423 -30.970 24.922 1.00 38.34 ? 245 ALA B CA 1 ATOM 4790 C C . ALA B 1 261 ? -1.666 -30.445 24.194 1.00 31.93 ? 245 ALA B C 1 ATOM 4791 O O . ALA B 1 261 ? -2.615 -31.188 23.931 1.00 28.76 ? 245 ALA B O 1 ATOM 4792 C CB . ALA B 1 261 ? -0.498 -30.614 26.395 1.00 44.41 ? 245 ALA B CB 1 ATOM 4793 N N . LYS B 1 262 ? -1.667 -29.166 23.863 1.00 29.67 ? 246 LYS B N 1 ATOM 4794 C CA . LYS B 1 262 ? -2.882 -28.560 23.349 1.00 32.84 ? 246 LYS B CA 1 ATOM 4795 C C . LYS B 1 262 ? -2.706 -27.862 22.010 1.00 29.27 ? 246 LYS B C 1 ATOM 4796 O O . LYS B 1 262 ? -3.622 -27.197 21.540 1.00 33.56 ? 246 LYS B O 1 ATOM 4797 C CB . LYS B 1 262 ? -3.433 -27.589 24.371 1.00 32.47 ? 246 LYS B CB 1 ATOM 4798 N N . LYS B 1 263 ? -1.543 -28.008 21.388 1.00 33.70 ? 247 LYS B N 1 ATOM 4799 C CA . LYS B 1 263 ? -1.301 -27.340 20.116 1.00 28.48 ? 247 LYS B CA 1 ATOM 4800 C C . LYS B 1 263 ? -0.230 -28.026 19.261 1.00 32.13 ? 247 LYS B C 1 ATOM 4801 O O . LYS B 1 263 ? 0.636 -28.728 19.790 1.00 33.04 ? 247 LYS B O 1 ATOM 4802 C CB . LYS B 1 263 ? -0.926 -25.898 20.371 1.00 32.35 ? 247 LYS B CB 1 ATOM 4803 N N . GLN B 1 264 ? -0.323 -27.834 17.941 1.00 29.16 ? 248 GLN B N 1 ATOM 4804 C CA . GLN B 1 264 ? 0.714 -28.251 16.991 1.00 27.59 ? 248 GLN B CA 1 ATOM 4805 C C . GLN B 1 264 ? 1.041 -27.097 16.058 1.00 29.63 ? 248 GLN B C 1 ATOM 4806 O O . GLN B 1 264 ? 0.168 -26.312 15.702 1.00 33.47 ? 248 GLN B O 1 ATOM 4807 C CB . GLN B 1 264 ? 0.261 -29.423 16.114 1.00 30.51 ? 248 GLN B CB 1 ATOM 4808 C CG . GLN B 1 264 ? 0.175 -30.770 16.792 1.00 32.15 ? 248 GLN B CG 1 ATOM 4809 C CD . GLN B 1 264 ? 0.235 -31.920 15.813 1.00 24.25 ? 248 GLN B CD 1 ATOM 4810 O OE1 . GLN B 1 264 ? -0.715 -32.674 15.668 1.00 23.91 ? 248 GLN B OE1 1 ATOM 4811 N NE2 . GLN B 1 264 ? 1.361 -32.056 15.137 1.00 26.90 ? 248 GLN B NE2 1 ATOM 4812 N N . GLU B 1 265 ? 2.296 -27.004 15.635 1.00 39.73 ? 249 GLU B N 1 ATOM 4813 C CA . GLU B 1 265 ? 2.651 -26.114 14.541 1.00 38.18 ? 249 GLU B CA 1 ATOM 4814 C C . GLU B 1 265 ? 2.526 -26.909 13.235 1.00 36.25 ? 249 GLU B C 1 ATOM 4815 O O . GLU B 1 265 ? 3.130 -27.972 13.094 1.00 34.45 ? 249 GLU B O 1 ATOM 4816 C CB . GLU B 1 265 ? 4.068 -25.556 14.721 1.00 35.72 ? 249 GLU B CB 1 ATOM 4817 C CG . GLU B 1 265 ? 4.156 -24.027 14.596 1.00 43.82 ? 249 GLU B CG 1 ATOM 4818 C CD . GLU B 1 265 ? 5.565 -23.517 14.258 1.00 61.57 ? 249 GLU B CD 1 ATOM 4819 O OE1 . GLU B 1 265 ? 6.490 -24.343 14.082 1.00 65.71 ? 249 GLU B OE1 1 ATOM 4820 O OE2 . GLU B 1 265 ? 5.748 -22.283 14.157 1.00 59.16 ? 249 GLU B OE2 1 ATOM 4821 N N . VAL B 1 266 ? 1.685 -26.424 12.318 1.00 37.93 ? 250 VAL B N 1 ATOM 4822 C CA . VAL B 1 266 ? 1.600 -26.966 10.959 1.00 33.84 ? 250 VAL B CA 1 ATOM 4823 C C . VAL B 1 266 ? 2.300 -25.993 10.035 1.00 31.37 ? 250 VAL B C 1 ATOM 4824 O O . VAL B 1 266 ? 2.104 -24.790 10.140 1.00 33.93 ? 250 VAL B O 1 ATOM 4825 C CB . VAL B 1 266 ? 0.144 -27.096 10.460 1.00 24.19 ? 250 VAL B CB 1 ATOM 4826 C CG1 . VAL B 1 266 ? 0.119 -27.451 8.986 1.00 29.35 ? 250 VAL B CG1 1 ATOM 4827 C CG2 . VAL B 1 266 ? -0.623 -28.123 11.253 1.00 27.51 ? 250 VAL B CG2 1 ATOM 4828 N N . VAL B 1 267 ? 3.105 -26.494 9.111 1.00 38.11 ? 251 VAL B N 1 ATOM 4829 C CA . VAL B 1 267 ? 3.781 -25.599 8.169 1.00 39.89 ? 251 VAL B CA 1 ATOM 4830 C C . VAL B 1 267 ? 3.816 -26.136 6.742 1.00 30.28 ? 251 VAL B C 1 ATOM 4831 O O . VAL B 1 267 ? 3.625 -27.320 6.507 1.00 30.76 ? 251 VAL B O 1 ATOM 4832 C CB . VAL B 1 267 ? 5.228 -25.294 8.615 1.00 41.12 ? 251 VAL B CB 1 ATOM 4833 C CG1 . VAL B 1 267 ? 5.244 -24.173 9.659 1.00 42.98 ? 251 VAL B CG1 1 ATOM 4834 C CG2 . VAL B 1 267 ? 5.906 -26.560 9.127 1.00 32.70 ? 251 VAL B CG2 1 ATOM 4835 N N . VAL B 1 268 ? 4.047 -25.245 5.788 1.00 33.41 ? 252 VAL B N 1 ATOM 4836 C CA . VAL B 1 268 ? 4.237 -25.659 4.409 1.00 28.00 ? 252 VAL B CA 1 ATOM 4837 C C . VAL B 1 268 ? 5.640 -25.362 3.938 1.00 25.28 ? 252 VAL B C 1 ATOM 4838 O O . VAL B 1 268 ? 6.336 -24.515 4.498 1.00 25.26 ? 252 VAL B O 1 ATOM 4839 C CB . VAL B 1 268 ? 3.276 -24.960 3.457 1.00 26.68 ? 252 VAL B CB 1 ATOM 4840 C CG1 . VAL B 1 268 ? 1.906 -25.584 3.565 1.00 29.56 ? 252 VAL B CG1 1 ATOM 4841 C CG2 . VAL B 1 268 ? 3.244 -23.471 3.727 1.00 23.94 ? 252 VAL B CG2 1 ATOM 4842 N N . LEU B 1 269 ? 6.062 -26.059 2.899 1.00 25.00 ? 253 LEU B N 1 ATOM 4843 C CA . LEU B 1 269 ? 7.353 -25.770 2.309 1.00 25.03 ? 253 LEU B CA 1 ATOM 4844 C C . LEU B 1 269 ? 7.217 -24.536 1.445 1.00 21.55 ? 253 LEU B C 1 ATOM 4845 O O . LEU B 1 269 ? 6.112 -24.101 1.129 1.00 22.76 ? 253 LEU B O 1 ATOM 4846 C CB . LEU B 1 269 ? 7.849 -26.950 1.475 1.00 25.69 ? 253 LEU B CB 1 ATOM 4847 C CG . LEU B 1 269 ? 8.354 -28.154 2.273 1.00 22.01 ? 253 LEU B CG 1 ATOM 4848 C CD1 . LEU B 1 269 ? 8.502 -29.374 1.391 1.00 26.04 ? 253 LEU B CD1 1 ATOM 4849 C CD2 . LEU B 1 269 ? 9.682 -27.823 2.928 1.00 25.76 ? 253 LEU B CD2 1 ATOM 4850 N N . GLY B 1 270 ? 8.351 -23.962 1.074 1.00 26.55 ? 254 GLY B N 1 ATOM 4851 C CA . GLY B 1 270 ? 8.354 -22.825 0.185 1.00 25.57 ? 254 GLY B CA 1 ATOM 4852 C C . GLY B 1 270 ? 8.055 -23.338 -1.199 1.00 23.66 ? 254 GLY B C 1 ATOM 4853 O O . GLY B 1 270 ? 8.163 -24.529 -1.453 1.00 30.45 ? 254 GLY B O 1 ATOM 4854 N N . SER B 1 271 ? 7.684 -22.442 -2.095 1.00 21.93 ? 255 SER B N 1 ATOM 4855 C CA . SER B 1 271 ? 7.416 -22.819 -3.459 1.00 22.29 ? 255 SER B CA 1 ATOM 4856 C C . SER B 1 271 ? 8.469 -23.767 -3.988 1.00 21.59 ? 255 SER B C 1 ATOM 4857 O O . SER B 1 271 ? 9.653 -23.641 -3.702 1.00 23.95 ? 255 SER B O 1 ATOM 4858 C CB . SER B 1 271 ? 7.368 -21.589 -4.345 1.00 23.25 ? 255 SER B CB 1 ATOM 4859 O OG . SER B 1 271 ? 7.307 -21.973 -5.703 1.00 24.65 ? 255 SER B OG 1 ATOM 4860 N N . GLN B 1 272 ? 8.023 -24.726 -4.777 1.00 22.67 ? 256 GLN B N 1 ATOM 4861 C CA . GLN B 1 272 ? 8.911 -25.690 -5.379 1.00 22.39 ? 256 GLN B CA 1 ATOM 4862 C C . GLN B 1 272 ? 9.082 -25.303 -6.822 1.00 20.31 ? 256 GLN B C 1 ATOM 4863 O O . GLN B 1 272 ? 9.511 -26.104 -7.637 1.00 21.68 ? 256 GLN B O 1 ATOM 4864 C CB . GLN B 1 272 ? 8.305 -27.085 -5.307 1.00 21.49 ? 256 GLN B CB 1 ATOM 4865 C CG . GLN B 1 272 ? 7.762 -27.429 -3.958 1.00 21.06 ? 256 GLN B CG 1 ATOM 4866 C CD . GLN B 1 272 ? 8.724 -27.063 -2.870 1.00 26.37 ? 256 GLN B CD 1 ATOM 4867 O OE1 . GLN B 1 272 ? 9.927 -27.230 -3.023 1.00 31.80 ? 256 GLN B OE1 1 ATOM 4868 N NE2 . GLN B 1 272 ? 8.208 -26.547 -1.767 1.00 27.46 ? 256 GLN B NE2 1 ATOM 4869 N N . GLU B 1 273 ? 8.724 -24.071 -7.149 1.00 21.20 ? 257 GLU B N 1 ATOM 4870 C CA . GLU B 1 273 ? 8.822 -23.611 -8.519 1.00 20.65 ? 257 GLU B CA 1 ATOM 4871 C C . GLU B 1 273 ? 10.255 -23.684 -9.019 1.00 23.74 ? 257 GLU B C 1 ATOM 4872 O O . GLU B 1 273 ? 10.495 -23.880 -10.207 1.00 23.86 ? 257 GLU B O 1 ATOM 4873 C CB . GLU B 1 273 ? 8.307 -22.184 -8.632 1.00 24.24 ? 257 GLU B CB 1 ATOM 4874 C CG . GLU B 1 273 ? 8.814 -21.429 -9.839 1.00 25.01 ? 257 GLU B CG 1 ATOM 4875 C CD . GLU B 1 273 ? 7.915 -20.271 -10.205 1.00 26.78 ? 257 GLU B CD 1 ATOM 4876 O OE1 . GLU B 1 273 ? 7.140 -19.820 -9.346 1.00 30.40 ? 257 GLU B OE1 1 ATOM 4877 O OE2 . GLU B 1 273 ? 7.967 -19.816 -11.362 1.00 33.17 ? 257 GLU B OE2 1 ATOM 4878 N N . GLY B 1 274 ? 11.204 -23.523 -8.107 1.00 23.61 ? 258 GLY B N 1 ATOM 4879 C CA . GLY B 1 274 ? 12.606 -23.505 -8.463 1.00 22.41 ? 258 GLY B CA 1 ATOM 4880 C C . GLY B 1 274 ? 13.165 -24.897 -8.624 1.00 19.88 ? 258 GLY B C 1 ATOM 4881 O O . GLY B 1 274 ? 13.991 -25.150 -9.495 1.00 18.46 ? 258 GLY B O 1 ATOM 4882 N N . ALA B 1 275 ? 12.718 -25.799 -7.763 1.00 17.43 ? 259 ALA B N 1 ATOM 4883 C CA . ALA B 1 275 ? 13.098 -27.195 -7.867 1.00 20.03 ? 259 ALA B CA 1 ATOM 4884 C C . ALA B 1 275 ? 12.626 -27.777 -9.208 1.00 17.24 ? 259 ALA B C 1 ATOM 4885 O O . ALA B 1 275 ? 13.333 -28.554 -9.844 1.00 15.72 ? 259 ALA B O 1 ATOM 4886 C CB . ALA B 1 275 ? 12.528 -27.977 -6.700 1.00 18.23 ? 259 ALA B CB 1 ATOM 4887 N N . MET B 1 276 ? 11.438 -27.365 -9.637 1.00 18.61 ? 260 MET B N 1 ATOM 4888 C CA . MET B 1 276 ? 10.848 -27.818 -10.894 1.00 16.74 ? 260 MET B CA 1 ATOM 4889 C C . MET B 1 276 ? 11.638 -27.313 -12.079 1.00 14.30 ? 260 MET B C 1 ATOM 4890 O O . MET B 1 276 ? 11.967 -28.054 -12.992 1.00 15.61 ? 260 MET B O 1 ATOM 4891 C CB . MET B 1 276 ? 9.408 -27.326 -11.017 1.00 14.50 ? 260 MET B CB 1 ATOM 4892 C CG . MET B 1 276 ? 8.688 -27.961 -12.160 1.00 19.66 ? 260 MET B CG 1 ATOM 4893 S SD . MET B 1 276 ? 8.715 -29.752 -12.053 1.00 21.37 ? 260 MET B SD 1 ATOM 4894 C CE . MET B 1 276 ? 7.954 -29.994 -10.481 1.00 13.23 ? 260 MET B CE 1 ATOM 4895 N N . HIS B 1 277 ? 11.961 -26.036 -12.055 1.00 15.44 ? 261 HIS B N 1 ATOM 4896 C CA . HIS B 1 277 ? 12.796 -25.473 -13.094 1.00 19.56 ? 261 HIS B CA 1 ATOM 4897 C C . HIS B 1 277 ? 14.092 -26.262 -13.294 1.00 16.26 ? 261 HIS B C 1 ATOM 4898 O O . HIS B 1 277 ? 14.446 -26.565 -14.422 1.00 18.69 ? 261 HIS B O 1 ATOM 4899 C CB . HIS B 1 277 ? 13.071 -24.005 -12.797 1.00 24.49 ? 261 HIS B CB 1 ATOM 4900 C CG . HIS B 1 277 ? 11.970 -23.096 -13.198 1.00 21.27 ? 261 HIS B CG 1 ATOM 4901 N ND1 . HIS B 1 277 ? 11.852 -21.791 -12.767 1.00 28.60 ? 261 HIS B ND1 1 ATOM 4902 C CD2 . HIS B 1 277 ? 10.893 -23.306 -14.014 1.00 23.28 ? 261 HIS B CD2 1 ATOM 4903 C CE1 . HIS B 1 277 ? 10.793 -21.246 -13.287 1.00 26.61 ? 261 HIS B CE1 1 ATOM 4904 N NE2 . HIS B 1 277 ? 10.182 -22.125 -14.049 1.00 24.55 ? 261 HIS B NE2 1 ATOM 4905 N N . THR B 1 278 ? 14.785 -26.601 -12.211 1.00 15.60 ? 262 THR B N 1 ATOM 4906 C CA . THR B 1 278 ? 16.026 -27.369 -12.306 1.00 18.74 ? 262 THR B CA 1 ATOM 4907 C C . THR B 1 278 ? 15.728 -28.716 -12.956 1.00 19.35 ? 262 THR B C 1 ATOM 4908 O O . THR B 1 278 ? 16.507 -29.223 -13.766 1.00 18.78 ? 262 THR B O 1 ATOM 4909 C CB . THR B 1 278 ? 16.672 -27.617 -10.916 1.00 18.94 ? 262 THR B CB 1 ATOM 4910 O OG1 . THR B 1 278 ? 16.838 -26.382 -10.226 1.00 19.89 ? 262 THR B OG1 1 ATOM 4911 C CG2 . THR B 1 278 ? 18.039 -28.276 -11.046 1.00 21.39 ? 262 THR B CG2 1 ATOM 4912 N N . ALA B 1 279 ? 14.583 -29.285 -12.597 1.00 20.30 ? 263 ALA B N 1 ATOM 4913 C CA . ALA B 1 279 ? 14.193 -30.614 -13.058 1.00 16.39 ? 263 ALA B CA 1 ATOM 4914 C C . ALA B 1 279 ? 13.878 -30.612 -14.545 1.00 13.61 ? 263 ALA B C 1 ATOM 4915 O O . ALA B 1 279 ? 14.079 -31.615 -15.228 1.00 15.07 ? 263 ALA B O 1 ATOM 4916 C CB . ALA B 1 279 ? 12.981 -31.110 -12.262 1.00 16.48 ? 263 ALA B CB 1 ATOM 4917 N N . LEU B 1 280 ? 13.380 -29.484 -15.038 1.00 13.50 ? 264 LEU B N 1 ATOM 4918 C CA . LEU B 1 280 ? 12.957 -29.363 -16.422 1.00 14.79 ? 264 LEU B CA 1 ATOM 4919 C C . LEU B 1 280 ? 14.062 -28.860 -17.320 1.00 18.95 ? 264 LEU B C 1 ATOM 4920 O O . LEU B 1 280 ? 13.868 -28.775 -18.514 1.00 20.97 ? 264 LEU B O 1 ATOM 4921 C CB . LEU B 1 280 ? 11.799 -28.395 -16.528 1.00 13.88 ? 264 LEU B CB 1 ATOM 4922 C CG . LEU B 1 280 ? 10.465 -28.902 -16.005 1.00 12.98 ? 264 LEU B CG 1 ATOM 4923 C CD1 . LEU B 1 280 ? 9.628 -27.724 -15.626 1.00 15.88 ? 264 LEU B CD1 1 ATOM 4924 C CD2 . LEU B 1 280 ? 9.776 -29.721 -17.071 1.00 13.90 ? 264 LEU B CD2 1 ATOM 4925 N N . THR B 1 281 ? 15.200 -28.486 -16.744 1.00 18.14 ? 265 THR B N 1 ATOM 4926 C CA . THR B 1 281 ? 16.339 -28.036 -17.536 1.00 20.61 ? 265 THR B CA 1 ATOM 4927 C C . THR B 1 281 ? 16.645 -29.135 -18.508 1.00 20.84 ? 265 THR B C 1 ATOM 4928 O O . THR B 1 281 ? 17.007 -30.235 -18.111 1.00 23.05 ? 265 THR B O 1 ATOM 4929 C CB . THR B 1 281 ? 17.600 -27.786 -16.684 1.00 18.90 ? 265 THR B CB 1 ATOM 4930 O OG1 . THR B 1 281 ? 17.341 -26.741 -15.750 1.00 21.70 ? 265 THR B OG1 1 ATOM 4931 C CG2 . THR B 1 281 ? 18.767 -27.367 -17.548 1.00 20.58 ? 265 THR B CG2 1 ATOM 4932 N N . GLY B 1 282 ? 16.491 -28.841 -19.787 1.00 14.92 ? 266 GLY B N 1 ATOM 4933 C CA . GLY B 1 282 ? 16.715 -29.832 -20.812 1.00 19.80 ? 266 GLY B CA 1 ATOM 4934 C C . GLY B 1 282 ? 15.467 -30.229 -21.588 1.00 21.06 ? 266 GLY B C 1 ATOM 4935 O O . GLY B 1 282 ? 15.566 -30.661 -22.744 1.00 23.12 ? 266 GLY B O 1 ATOM 4936 N N . ALA B 1 283 ? 14.297 -30.103 -20.966 1.00 18.40 ? 267 ALA B N 1 ATOM 4937 C CA . ALA B 1 283 ? 13.058 -30.431 -21.646 1.00 14.51 ? 267 ALA B CA 1 ATOM 4938 C C . ALA B 1 283 ? 12.754 -29.317 -22.614 1.00 13.41 ? 267 ALA B C 1 ATOM 4939 O O . ALA B 1 283 ? 13.052 -28.155 -22.374 1.00 18.53 ? 267 ALA B O 1 ATOM 4940 C CB . ALA B 1 283 ? 11.898 -30.619 -20.653 1.00 11.40 ? 267 ALA B CB 1 ATOM 4941 N N . THR B 1 284 ? 12.152 -29.673 -23.727 1.00 14.92 ? 268 THR B N 1 ATOM 4942 C CA . THR B 1 284 ? 11.825 -28.691 -24.737 1.00 18.67 ? 268 THR B CA 1 ATOM 4943 C C . THR B 1 284 ? 10.776 -27.731 -24.246 1.00 17.80 ? 268 THR B C 1 ATOM 4944 O O . THR B 1 284 ? 9.675 -28.138 -23.897 1.00 15.27 ? 268 THR B O 1 ATOM 4945 C CB . THR B 1 284 ? 11.308 -29.367 -25.995 1.00 19.99 ? 268 THR B CB 1 ATOM 4946 O OG1 . THR B 1 284 ? 12.315 -30.253 -26.493 1.00 17.22 ? 268 THR B OG1 1 ATOM 4947 C CG2 . THR B 1 284 ? 10.970 -28.337 -27.053 1.00 19.74 ? 268 THR B CG2 1 ATOM 4948 N N . GLU B 1 285 ? 11.144 -26.457 -24.221 1.00 18.75 ? 269 GLU B N 1 ATOM 4949 C CA . GLU B 1 285 ? 10.257 -25.362 -23.864 1.00 17.20 ? 269 GLU B CA 1 ATOM 4950 C C . GLU B 1 285 ? 9.435 -25.031 -25.097 1.00 17.89 ? 269 GLU B C 1 ATOM 4951 O O . GLU B 1 285 ? 9.933 -25.100 -26.221 1.00 21.27 ? 269 GLU B O 1 ATOM 4952 C CB . GLU B 1 285 ? 11.121 -24.159 -23.461 1.00 25.21 ? 269 GLU B CB 1 ATOM 4953 C CG . GLU B 1 285 ? 10.552 -23.215 -22.405 1.00 32.32 ? 269 GLU B CG 1 ATOM 4954 C CD . GLU B 1 285 ? 11.566 -22.130 -21.971 1.00 34.90 ? 269 GLU B CD 1 ATOM 4955 O OE1 . GLU B 1 285 ? 12.544 -22.466 -21.252 1.00 28.97 ? 269 GLU B OE1 1 ATOM 4956 O OE2 . GLU B 1 285 ? 11.367 -20.950 -22.349 1.00 39.26 ? 269 GLU B OE2 1 ATOM 4957 N N . ILE B 1 286 ? 8.175 -24.676 -24.917 1.00 20.32 ? 270 ILE B N 1 ATOM 4958 C CA . ILE B 1 286 ? 7.324 -24.376 -26.060 1.00 21.20 ? 270 ILE B CA 1 ATOM 4959 C C . ILE B 1 286 ? 6.459 -23.152 -25.771 1.00 17.53 ? 270 ILE B C 1 ATOM 4960 O O . ILE B 1 286 ? 6.353 -22.736 -24.633 1.00 22.86 ? 270 ILE B O 1 ATOM 4961 C CB . ILE B 1 286 ? 6.456 -25.585 -26.437 1.00 19.46 ? 270 ILE B CB 1 ATOM 4962 C CG1 . ILE B 1 286 ? 5.623 -26.045 -25.249 1.00 20.21 ? 270 ILE B CG1 1 ATOM 4963 C CG2 . ILE B 1 286 ? 7.311 -26.744 -26.849 1.00 23.90 ? 270 ILE B CG2 1 ATOM 4964 C CD1 . ILE B 1 286 ? 4.551 -27.010 -25.636 1.00 23.38 ? 270 ILE B CD1 1 ATOM 4965 N N . GLN B 1 287 ? 5.846 -22.567 -26.792 1.00 21.47 ? 271 GLN B N 1 ATOM 4966 C CA . GLN B 1 287 ? 5.168 -21.288 -26.581 1.00 29.69 ? 271 GLN B CA 1 ATOM 4967 C C . GLN B 1 287 ? 3.669 -21.429 -26.706 1.00 22.38 ? 271 GLN B C 1 ATOM 4968 O O . GLN B 1 287 ? 3.175 -21.767 -27.771 1.00 20.98 ? 271 GLN B O 1 ATOM 4969 C CB . GLN B 1 287 ? 5.684 -20.214 -27.558 1.00 38.34 ? 271 GLN B CB 1 ATOM 4970 C CG . GLN B 1 287 ? 4.970 -20.188 -28.917 1.00 41.90 ? 271 GLN B CG 1 ATOM 4971 C CD . GLN B 1 287 ? 5.736 -19.420 -29.988 1.00 41.93 ? 271 GLN B CD 1 ATOM 4972 O OE1 . GLN B 1 287 ? 6.945 -19.213 -29.873 1.00 59.28 ? 271 GLN B OE1 1 ATOM 4973 N NE2 . GLN B 1 287 ? 5.028 -18.992 -31.035 1.00 38.11 ? 271 GLN B NE2 1 ATOM 4974 N N . THR B 1 288 ? 2.959 -21.159 -25.609 1.00 25.20 ? 272 THR B N 1 ATOM 4975 C CA . THR B 1 288 ? 1.499 -21.224 -25.575 1.00 24.12 ? 272 THR B CA 1 ATOM 4976 C C . THR B 1 288 ? 0.866 -19.930 -25.057 1.00 34.11 ? 272 THR B C 1 ATOM 4977 O O . THR B 1 288 ? 1.335 -19.353 -24.076 1.00 42.10 ? 272 THR B O 1 ATOM 4978 C CB . THR B 1 288 ? 0.992 -22.438 -24.714 1.00 29.14 ? 272 THR B CB 1 ATOM 4979 O OG1 . THR B 1 288 ? -0.058 -22.038 -23.822 1.00 29.75 ? 272 THR B OG1 1 ATOM 4980 C CG2 . THR B 1 288 ? 2.100 -23.053 -23.908 1.00 27.83 ? 272 THR B CG2 1 ATOM 4981 N N . SER B 1 289 ? -0.189 -19.477 -25.738 1.00 30.48 ? 273 SER B N 1 ATOM 4982 C CA . SER B 1 289 ? -1.025 -18.376 -25.271 1.00 28.29 ? 273 SER B CA 1 ATOM 4983 C C . SER B 1 289 ? -2.303 -18.949 -24.689 1.00 28.62 ? 273 SER B C 1 ATOM 4984 O O . SER B 1 289 ? -3.332 -19.010 -25.358 1.00 29.95 ? 273 SER B O 1 ATOM 4985 C CB . SER B 1 289 ? -1.383 -17.456 -26.427 1.00 39.71 ? 273 SER B CB 1 ATOM 4986 O OG . SER B 1 289 ? -2.479 -17.966 -27.180 1.00 47.57 ? 273 SER B OG 1 ATOM 4987 N N . GLY B 1 290 ? -2.240 -19.382 -23.441 1.00 34.43 ? 274 GLY B N 1 ATOM 4988 C CA . GLY B 1 290 ? -3.377 -20.038 -22.833 1.00 33.27 ? 274 GLY B CA 1 ATOM 4989 C C . GLY B 1 290 ? -3.692 -21.353 -23.510 1.00 26.25 ? 274 GLY B C 1 ATOM 4990 O O . GLY B 1 290 ? -3.087 -22.375 -23.202 1.00 29.29 ? 274 GLY B O 1 ATOM 4991 N N . THR B 1 291 ? -4.641 -21.341 -24.434 1.00 23.53 ? 275 THR B N 1 ATOM 4992 C CA . THR B 1 291 ? -5.192 -22.603 -24.917 1.00 24.82 ? 275 THR B CA 1 ATOM 4993 C C . THR B 1 291 ? -4.550 -23.034 -26.203 1.00 19.78 ? 275 THR B C 1 ATOM 4994 O O . THR B 1 291 ? -4.748 -24.163 -26.628 1.00 19.37 ? 275 THR B O 1 ATOM 4995 C CB . THR B 1 291 ? -6.698 -22.532 -25.219 1.00 22.21 ? 275 THR B CB 1 ATOM 4996 O OG1 . THR B 1 291 ? -6.897 -21.858 -26.468 1.00 31.20 ? 275 THR B OG1 1 ATOM 4997 C CG2 . THR B 1 291 ? -7.467 -21.826 -24.123 1.00 25.96 ? 275 THR B CG2 1 ATOM 4998 N N . THR B 1 292 ? -3.815 -22.129 -26.839 1.00 20.41 ? 276 THR B N 1 ATOM 4999 C CA . THR B 1 292 ? -3.218 -22.421 -28.139 1.00 19.42 ? 276 THR B CA 1 ATOM 5000 C C . THR B 1 292 ? -1.711 -22.558 -28.057 1.00 16.18 ? 276 THR B C 1 ATOM 5001 O O . THR B 1 292 ? -1.013 -21.721 -27.510 1.00 16.50 ? 276 THR B O 1 ATOM 5002 C CB . THR B 1 292 ? -3.599 -21.375 -29.207 1.00 22.52 ? 276 THR B CB 1 ATOM 5003 O OG1 . THR B 1 292 ? -5.019 -21.372 -29.391 1.00 27.32 ? 276 THR B OG1 1 ATOM 5004 C CG2 . THR B 1 292 ? -2.951 -21.700 -30.537 1.00 20.60 ? 276 THR B CG2 1 ATOM 5005 N N . THR B 1 293 ? -1.222 -23.642 -28.627 1.00 14.85 ? 277 THR B N 1 ATOM 5006 C CA . THR B 1 293 ? 0.187 -23.935 -28.667 1.00 12.13 ? 277 THR B CA 1 ATOM 5007 C C . THR B 1 293 ? 0.588 -24.102 -30.147 1.00 14.56 ? 277 THR B C 1 ATOM 5008 O O . THR B 1 293 ? -0.091 -24.797 -30.896 1.00 10.59 ? 277 THR B O 1 ATOM 5009 C CB . THR B 1 293 ? 0.475 -25.212 -27.887 1.00 11.82 ? 277 THR B CB 1 ATOM 5010 O OG1 . THR B 1 293 ? 0.047 -25.059 -26.529 1.00 12.52 ? 277 THR B OG1 1 ATOM 5011 C CG2 . THR B 1 293 ? 1.948 -25.500 -27.919 1.00 16.75 ? 277 THR B CG2 1 ATOM 5012 N N . ILE B 1 294 ? 1.660 -23.428 -30.565 1.00 12.16 ? 278 ILE B N 1 ATOM 5013 C CA . ILE B 1 294 ? 2.085 -23.440 -31.960 1.00 15.32 ? 278 ILE B CA 1 ATOM 5014 C C . ILE B 1 294 ? 3.328 -24.303 -32.093 1.00 13.99 ? 278 ILE B C 1 ATOM 5015 O O . ILE B 1 294 ? 4.259 -24.194 -31.298 1.00 10.88 ? 278 ILE B O 1 ATOM 5016 C CB . ILE B 1 294 ? 2.364 -22.003 -32.512 1.00 19.76 ? 278 ILE B CB 1 ATOM 5017 C CG1 . ILE B 1 294 ? 1.096 -21.166 -32.508 1.00 21.01 ? 278 ILE B CG1 1 ATOM 5018 C CG2 . ILE B 1 294 ? 2.902 -22.039 -33.933 1.00 16.62 ? 278 ILE B CG2 1 ATOM 5019 C CD1 . ILE B 1 294 ? -0.043 -21.778 -33.269 1.00 22.10 ? 278 ILE B CD1 1 ATOM 5020 N N . PHE B 1 295 ? 3.311 -25.176 -33.096 1.00 13.32 ? 279 PHE B N 1 ATOM 5021 C CA . PHE B 1 295 ? 4.407 -26.089 -33.382 1.00 15.49 ? 279 PHE B CA 1 ATOM 5022 C C . PHE B 1 295 ? 4.951 -25.855 -34.778 1.00 15.65 ? 279 PHE B C 1 ATOM 5023 O O . PHE B 1 295 ? 4.326 -25.208 -35.607 1.00 16.91 ? 279 PHE B O 1 ATOM 5024 C CB . PHE B 1 295 ? 3.920 -27.528 -33.278 1.00 13.33 ? 279 PHE B CB 1 ATOM 5025 C CG . PHE B 1 295 ? 3.610 -27.948 -31.889 1.00 14.14 ? 279 PHE B CG 1 ATOM 5026 C CD1 . PHE B 1 295 ? 2.397 -27.640 -31.324 1.00 11.95 ? 279 PHE B CD1 1 ATOM 5027 C CD2 . PHE B 1 295 ? 4.536 -28.643 -31.135 1.00 12.61 ? 279 PHE B CD2 1 ATOM 5028 C CE1 . PHE B 1 295 ? 2.105 -28.006 -30.024 1.00 14.84 ? 279 PHE B CE1 1 ATOM 5029 C CE2 . PHE B 1 295 ? 4.251 -29.021 -29.842 1.00 12.98 ? 279 PHE B CE2 1 ATOM 5030 C CZ . PHE B 1 295 ? 3.039 -28.694 -29.283 1.00 13.84 ? 279 PHE B CZ 1 ATOM 5031 N N . ALA B 1 296 ? 6.138 -26.373 -35.026 1.00 18.20 ? 280 ALA B N 1 ATOM 5032 C CA . ALA B 1 296 ? 6.685 -26.398 -36.368 1.00 24.86 ? 280 ALA B CA 1 ATOM 5033 C C . ALA B 1 296 ? 6.221 -27.685 -37.004 1.00 21.23 ? 280 ALA B C 1 ATOM 5034 O O . ALA B 1 296 ? 6.747 -28.751 -36.704 1.00 20.40 ? 280 ALA B O 1 ATOM 5035 C CB . ALA B 1 296 ? 8.203 -26.351 -36.318 1.00 28.34 ? 280 ALA B CB 1 ATOM 5036 N N . GLY B 1 297 ? 5.226 -27.592 -37.879 1.00 19.99 ? 281 GLY B N 1 ATOM 5037 C CA . GLY B 1 297 ? 4.637 -28.782 -38.465 1.00 17.66 ? 281 GLY B CA 1 ATOM 5038 C C . GLY B 1 297 ? 5.456 -29.478 -39.546 1.00 15.69 ? 281 GLY B C 1 ATOM 5039 O O . GLY B 1 297 ? 6.399 -28.926 -40.126 1.00 16.73 ? 281 GLY B O 1 ATOM 5040 N N . HIS B 1 298 ? 5.074 -30.725 -39.801 1.00 14.96 ? 282 HIS B N 1 ATOM 5041 C CA . HIS B 1 298 ? 5.585 -31.505 -40.915 1.00 11.88 ? 282 HIS B CA 1 ATOM 5042 C C . HIS B 1 298 ? 4.463 -32.368 -41.439 1.00 9.27 ? 282 HIS B C 1 ATOM 5043 O O . HIS B 1 298 ? 3.984 -33.233 -40.748 1.00 10.66 ? 282 HIS B O 1 ATOM 5044 C CB . HIS B 1 298 ? 6.681 -32.430 -40.445 1.00 16.43 ? 282 HIS B CB 1 ATOM 5045 C CG . HIS B 1 298 ? 7.799 -31.740 -39.749 1.00 21.41 ? 282 HIS B CG 1 ATOM 5046 N ND1 . HIS B 1 298 ? 8.890 -31.225 -40.414 1.00 24.57 ? 282 HIS B ND1 1 ATOM 5047 C CD2 . HIS B 1 298 ? 8.023 -31.509 -38.429 1.00 23.28 ? 282 HIS B CD2 1 ATOM 5048 C CE1 . HIS B 1 298 ? 9.725 -30.696 -39.541 1.00 23.55 ? 282 HIS B CE1 1 ATOM 5049 N NE2 . HIS B 1 298 ? 9.218 -30.855 -38.332 1.00 22.40 ? 282 HIS B NE2 1 ATOM 5050 N N . LEU B 1 299 ? 4.060 -32.155 -42.673 1.00 8.13 ? 283 LEU B N 1 ATOM 5051 C CA . LEU B 1 299 ? 2.974 -32.905 -43.244 1.00 9.16 ? 283 LEU B CA 1 ATOM 5052 C C . LEU B 1 299 ? 3.492 -33.694 -44.415 1.00 10.31 ? 283 LEU B C 1 ATOM 5053 O O . LEU B 1 299 ? 4.315 -33.212 -45.167 1.00 10.67 ? 283 LEU B O 1 ATOM 5054 C CB . LEU B 1 299 ? 1.884 -31.969 -43.750 1.00 12.13 ? 283 LEU B CB 1 ATOM 5055 C CG . LEU B 1 299 ? 0.830 -31.449 -42.795 1.00 10.83 ? 283 LEU B CG 1 ATOM 5056 C CD1 . LEU B 1 299 ? -0.133 -30.554 -43.567 1.00 10.79 ? 283 LEU B CD1 1 ATOM 5057 C CD2 . LEU B 1 299 ? 0.090 -32.587 -42.124 1.00 10.92 ? 283 LEU B CD2 1 ATOM 5058 N N . LYS B 1 300 ? 3.009 -34.917 -44.553 1.00 10.04 ? 284 LYS B N 1 ATOM 5059 C CA . LYS B 1 300 ? 3.172 -35.656 -45.781 1.00 9.99 ? 284 LYS B CA 1 ATOM 5060 C C . LYS B 1 300 ? 1.802 -35.747 -46.444 1.00 13.45 ? 284 LYS B C 1 ATOM 5061 O O . LYS B 1 300 ? 0.845 -36.227 -45.849 1.00 11.09 ? 284 LYS B O 1 ATOM 5062 C CB . LYS B 1 300 ? 3.767 -37.036 -45.507 1.00 10.43 ? 284 LYS B CB 1 ATOM 5063 C CG . LYS B 1 300 ? 3.242 -38.120 -46.430 1.00 19.02 ? 284 LYS B CG 1 ATOM 5064 C CD . LYS B 1 300 ? 4.348 -38.990 -47.015 1.00 25.44 ? 284 LYS B CD 1 ATOM 5065 C CE . LYS B 1 300 ? 4.079 -39.352 -48.482 1.00 27.04 ? 284 LYS B CE 1 ATOM 5066 N NZ . LYS B 1 300 ? 4.091 -38.173 -49.431 1.00 18.78 ? 284 LYS B NZ 1 ATOM 5067 N N . CYS B 1 301 ? 1.719 -35.277 -47.689 1.00 13.08 ? 285 CYS B N 1 ATOM 5068 C CA . CYS B 1 301 ? 0.461 -35.164 -48.409 1.00 11.61 ? 285 CYS B CA 1 ATOM 5069 C C . CYS B 1 301 ? 0.423 -35.963 -49.698 1.00 9.72 ? 285 CYS B C 1 ATOM 5070 O O . CYS B 1 301 ? 1.433 -36.166 -50.348 1.00 10.60 ? 285 CYS B O 1 ATOM 5071 C CB . CYS B 1 301 ? 0.192 -33.707 -48.776 1.00 11.77 ? 285 CYS B CB 1 ATOM 5072 S SG . CYS B 1 301 ? -0.153 -32.606 -47.400 1.00 20.16 ? 285 CYS B SG 1 ATOM 5073 N N . ARG B 1 302 ? -0.769 -36.408 -50.048 1.00 10.16 ? 286 ARG B N 1 ATOM 5074 C CA . ARG B 1 302 ? -1.057 -36.938 -51.367 1.00 8.85 ? 286 ARG B CA 1 ATOM 5075 C C . ARG B 1 302 ? -1.992 -35.946 -52.062 1.00 7.64 ? 286 ARG B C 1 ATOM 5076 O O . ARG B 1 302 ? -3.029 -35.599 -51.530 1.00 10.56 ? 286 ARG B O 1 ATOM 5077 C CB . ARG B 1 302 ? -1.684 -38.340 -51.249 1.00 6.66 ? 286 ARG B CB 1 ATOM 5078 C CG . ARG B 1 302 ? -2.401 -38.877 -52.486 1.00 6.28 ? 286 ARG B CG 1 ATOM 5079 C CD . ARG B 1 302 ? -1.518 -39.002 -53.749 1.00 7.09 ? 286 ARG B CD 1 ATOM 5080 N NE . ARG B 1 302 ? -0.279 -39.734 -53.507 1.00 6.91 ? 286 ARG B NE 1 ATOM 5081 C CZ . ARG B 1 302 ? -0.166 -41.050 -53.543 1.00 6.05 ? 286 ARG B CZ 1 ATOM 5082 N NH1 . ARG B 1 302 ? -1.229 -41.810 -53.786 1.00 8.42 ? 286 ARG B NH1 1 ATOM 5083 N NH2 . ARG B 1 302 ? 1.012 -41.615 -53.308 1.00 6.27 ? 286 ARG B NH2 1 ATOM 5084 N N . LEU B 1 303 ? -1.586 -35.438 -53.218 1.00 9.48 ? 287 LEU B N 1 ATOM 5085 C CA . LEU B 1 303 ? -2.456 -34.671 -54.103 1.00 8.78 ? 287 LEU B CA 1 ATOM 5086 C C . LEU B 1 303 ? -3.068 -35.581 -55.162 1.00 8.35 ? 287 LEU B C 1 ATOM 5087 O O . LEU B 1 303 ? -2.353 -36.327 -55.830 1.00 7.81 ? 287 LEU B O 1 ATOM 5088 C CB . LEU B 1 303 ? -1.668 -33.585 -54.839 1.00 9.65 ? 287 LEU B CB 1 ATOM 5089 C CG . LEU B 1 303 ? -1.336 -32.244 -54.178 1.00 16.66 ? 287 LEU B CG 1 ATOM 5090 C CD1 . LEU B 1 303 ? -1.181 -32.366 -52.680 1.00 13.83 ? 287 LEU B CD1 1 ATOM 5091 C CD2 . LEU B 1 303 ? -0.073 -31.662 -54.808 1.00 10.95 ? 287 LEU B CD2 1 ATOM 5092 N N . LYS B 1 304 ? -4.386 -35.487 -55.329 1.00 6.81 ? 288 LYS B N 1 ATOM 5093 C CA . LYS B 1 304 ? -5.109 -36.215 -56.364 1.00 7.63 ? 288 LYS B CA 1 ATOM 5094 C C . LYS B 1 304 ? -5.818 -35.270 -57.290 1.00 8.27 ? 288 LYS B C 1 ATOM 5095 O O . LYS B 1 304 ? -6.608 -34.452 -56.871 1.00 9.05 ? 288 LYS B O 1 ATOM 5096 C CB . LYS B 1 304 ? -6.148 -37.126 -55.750 1.00 8.00 ? 288 LYS B CB 1 ATOM 5097 C CG . LYS B 1 304 ? -5.597 -38.096 -54.742 1.00 6.79 ? 288 LYS B CG 1 ATOM 5098 C CD . LYS B 1 304 ? -6.688 -39.005 -54.253 1.00 6.43 ? 288 LYS B CD 1 ATOM 5099 C CE . LYS B 1 304 ? -6.194 -39.941 -53.183 1.00 14.94 ? 288 LYS B CE 1 ATOM 5100 N NZ . LYS B 1 304 ? -7.286 -40.758 -52.606 1.00 17.65 ? 288 LYS B NZ 1 ATOM 5101 N N . MET B 1 305 ? -5.542 -35.382 -58.566 1.00 11.03 ? 289 MET B N 1 ATOM 5102 C CA . MET B 1 305 ? -6.188 -34.493 -59.513 1.00 13.96 ? 289 MET B CA 1 ATOM 5103 C C . MET B 1 305 ? -6.464 -35.289 -60.749 1.00 12.34 ? 289 MET B C 1 ATOM 5104 O O . MET B 1 305 ? -6.064 -36.435 -60.844 1.00 11.55 ? 289 MET B O 1 ATOM 5105 C CB . MET B 1 305 ? -5.282 -33.306 -59.835 1.00 13.44 ? 289 MET B CB 1 ATOM 5106 C CG . MET B 1 305 ? -3.942 -33.731 -60.386 1.00 14.94 ? 289 MET B CG 1 ATOM 5107 S SD . MET B 1 305 ? -2.745 -32.415 -60.611 1.00 26.39 ? 289 MET B SD 1 ATOM 5108 C CE . MET B 1 305 ? -3.082 -31.391 -59.179 1.00 21.12 ? 289 MET B CE 1 ATOM 5109 N N . ASP B 1 306 ? -7.154 -34.673 -61.696 1.00 16.61 ? 290 ASP B N 1 ATOM 5110 C CA . ASP B 1 306 ? -7.423 -35.306 -62.964 1.00 15.25 ? 290 ASP B CA 1 ATOM 5111 C C . ASP B 1 306 ? -6.128 -35.591 -63.698 1.00 11.20 ? 290 ASP B C 1 ATOM 5112 O O . ASP B 1 306 ? -5.106 -34.965 -63.457 1.00 12.01 ? 290 ASP B O 1 ATOM 5113 C CB . ASP B 1 306 ? -8.328 -34.408 -63.803 1.00 14.49 ? 290 ASP B CB 1 ATOM 5114 C CG . ASP B 1 306 ? -9.779 -34.462 -63.359 1.00 21.66 ? 290 ASP B CG 1 ATOM 5115 O OD1 . ASP B 1 306 ? -10.187 -35.453 -62.721 1.00 22.58 ? 290 ASP B OD1 1 ATOM 5116 O OD2 . ASP B 1 306 ? -10.526 -33.511 -63.657 1.00 34.29 ? 290 ASP B OD2 1 ATOM 5117 N N . LYS B 1 307 ? -6.193 -36.570 -64.586 1.00 12.74 ? 291 LYS B N 1 ATOM 5118 C CA . LYS B 1 307 ? -5.077 -36.961 -65.414 1.00 9.80 ? 291 LYS B CA 1 ATOM 5119 C C . LYS B 1 307 ? -4.475 -35.745 -66.047 1.00 10.66 ? 291 LYS B C 1 ATOM 5120 O O . LYS B 1 307 ? -4.985 -35.235 -67.034 1.00 13.80 ? 291 LYS B O 1 ATOM 5121 C CB . LYS B 1 307 ? -5.571 -37.895 -66.504 1.00 14.63 ? 291 LYS B CB 1 ATOM 5122 C CG . LYS B 1 307 ? -4.852 -39.212 -66.588 1.00 10.61 ? 291 LYS B CG 1 ATOM 5123 C CD . LYS B 1 307 ? -5.444 -40.043 -67.695 1.00 13.72 ? 291 LYS B CD 1 ATOM 5124 C CE . LYS B 1 307 ? -5.066 -39.494 -69.068 1.00 17.47 ? 291 LYS B CE 1 ATOM 5125 N NZ . LYS B 1 307 ? -3.644 -39.767 -69.459 1.00 15.15 ? 291 LYS B NZ 1 ATOM 5126 N N . LEU B 1 308 ? -3.386 -35.279 -65.454 1.00 13.15 ? 292 LEU B N 1 ATOM 5127 C CA . LEU B 1 308 ? -2.612 -34.147 -65.959 1.00 11.34 ? 292 LEU B CA 1 ATOM 5128 C C . LEU B 1 308 ? -1.156 -34.504 -66.123 1.00 14.41 ? 292 LEU B C 1 ATOM 5129 O O . LEU B 1 308 ? -0.536 -35.075 -65.223 1.00 16.63 ? 292 LEU B O 1 ATOM 5130 C CB . LEU B 1 308 ? -2.688 -32.974 -64.996 1.00 15.38 ? 292 LEU B CB 1 ATOM 5131 C CG . LEU B 1 308 ? -3.923 -32.100 -65.148 1.00 22.92 ? 292 LEU B CG 1 ATOM 5132 C CD1 . LEU B 1 308 ? -4.587 -31.790 -63.817 1.00 17.81 ? 292 LEU B CD1 1 ATOM 5133 C CD2 . LEU B 1 308 ? -3.509 -30.819 -65.836 1.00 33.62 ? 292 LEU B CD2 1 ATOM 5134 N N . THR B 1 309 ? -0.608 -34.139 -67.269 1.00 14.55 ? 293 THR B N 1 ATOM 5135 C CA . THR B 1 309 ? 0.799 -34.312 -67.519 1.00 12.27 ? 293 THR B CA 1 ATOM 5136 C C . THR B 1 309 ? 1.526 -33.190 -66.769 1.00 14.49 ? 293 THR B C 1 ATOM 5137 O O . THR B 1 309 ? 1.502 -32.059 -67.212 1.00 18.62 ? 293 THR B O 1 ATOM 5138 C CB . THR B 1 309 ? 1.107 -34.228 -69.049 1.00 16.03 ? 293 THR B CB 1 ATOM 5139 O OG1 . THR B 1 309 ? 0.136 -34.962 -69.820 1.00 27.29 ? 293 THR B OG1 1 ATOM 5140 C CG2 . THR B 1 309 ? 2.480 -34.790 -69.334 1.00 20.51 ? 293 THR B CG2 1 ATOM 5141 N N . LEU B 1 310 ? 2.157 -33.499 -65.632 1.00 14.04 ? 294 LEU B N 1 ATOM 5142 C CA . LEU B 1 310 ? 2.947 -32.519 -64.871 1.00 12.99 ? 294 LEU B CA 1 ATOM 5143 C C . LEU B 1 310 ? 4.381 -32.352 -65.403 1.00 14.36 ? 294 LEU B C 1 ATOM 5144 O O . LEU B 1 310 ? 4.953 -33.286 -65.954 1.00 13.44 ? 294 LEU B O 1 ATOM 5145 C CB . LEU B 1 310 ? 3.021 -32.911 -63.387 1.00 10.18 ? 294 LEU B CB 1 ATOM 5146 C CG . LEU B 1 310 ? 1.721 -33.054 -62.594 1.00 10.32 ? 294 LEU B CG 1 ATOM 5147 C CD1 . LEU B 1 310 ? 1.994 -33.448 -61.165 1.00 11.52 ? 294 LEU B CD1 1 ATOM 5148 C CD2 . LEU B 1 310 ? 0.945 -31.761 -62.619 1.00 18.08 ? 294 LEU B CD2 1 ATOM 5149 N N . LYS B 1 311 ? 4.970 -31.170 -65.205 1.00 16.61 ? 295 LYS B N 1 ATOM 5150 C CA . LYS B 1 311 ? 6.376 -30.941 -65.544 1.00 15.18 ? 295 LYS B CA 1 ATOM 5151 C C . LYS B 1 311 ? 7.339 -31.131 -64.347 1.00 15.55 ? 295 LYS B C 1 ATOM 5152 O O . LYS B 1 311 ? 7.531 -30.224 -63.544 1.00 15.37 ? 295 LYS B O 1 ATOM 5153 C CB . LYS B 1 311 ? 6.552 -29.541 -66.137 1.00 15.92 ? 295 LYS B CB 1 ATOM 5154 C CG . LYS B 1 311 ? 7.881 -29.362 -66.866 1.00 25.60 ? 295 LYS B CG 1 ATOM 5155 C CD . LYS B 1 311 ? 7.882 -28.154 -67.782 1.00 39.22 ? 295 LYS B CD 1 ATOM 5156 C CE . LYS B 1 311 ? 9.088 -27.260 -67.532 1.00 46.59 ? 295 LYS B CE 1 ATOM 5157 N NZ . LYS B 1 311 ? 9.082 -26.058 -68.420 1.00 51.88 ? 295 LYS B NZ 1 ATOM 5158 N N . GLY B 1 312 ? 7.962 -32.304 -64.255 1.00 15.70 ? 296 GLY B N 1 ATOM 5159 C CA . GLY B 1 312 ? 8.829 -32.622 -63.138 1.00 14.20 ? 296 GLY B CA 1 ATOM 5160 C C . GLY B 1 312 ? 10.100 -31.808 -63.155 1.00 12.51 ? 296 GLY B C 1 ATOM 5161 O O . GLY B 1 312 ? 10.685 -31.583 -64.204 1.00 13.05 ? 296 GLY B O 1 ATOM 5162 N N . MET B 1 313 ? 10.528 -31.368 -61.979 1.00 12.02 ? 297 MET B N 1 ATOM 5163 C CA . MET B 1 313 ? 11.754 -30.596 -61.836 1.00 17.56 ? 297 MET B CA 1 ATOM 5164 C C . MET B 1 313 ? 12.918 -31.477 -61.425 1.00 18.48 ? 297 MET B C 1 ATOM 5165 O O . MET B 1 313 ? 12.803 -32.269 -60.499 1.00 20.04 ? 297 MET B O 1 ATOM 5166 C CB . MET B 1 313 ? 11.587 -29.498 -60.788 1.00 18.37 ? 297 MET B CB 1 ATOM 5167 C CG . MET B 1 313 ? 12.846 -28.688 -60.549 1.00 17.70 ? 297 MET B CG 1 ATOM 5168 S SD . MET B 1 313 ? 13.011 -27.343 -61.728 1.00 25.48 ? 297 MET B SD 1 ATOM 5169 C CE . MET B 1 313 ? 11.696 -26.296 -61.124 1.00 28.74 ? 297 MET B CE 1 ATOM 5170 N N . SER B 1 314 ? 14.047 -31.316 -62.113 1.00 20.93 ? 298 SER B N 1 ATOM 5171 C CA . SER B 1 314 ? 15.277 -32.005 -61.745 1.00 23.63 ? 298 SER B CA 1 ATOM 5172 C C . SER B 1 314 ? 16.311 -30.994 -61.244 1.00 23.73 ? 298 SER B C 1 ATOM 5173 O O . SER B 1 314 ? 16.522 -29.940 -61.853 1.00 23.06 ? 298 SER B O 1 ATOM 5174 C CB . SER B 1 314 ? 15.823 -32.805 -62.921 1.00 23.58 ? 298 SER B CB 1 ATOM 5175 O OG . SER B 1 314 ? 15.964 -34.163 -62.556 1.00 29.61 ? 298 SER B OG 1 ATOM 5176 N N . TYR B 1 315 ? 16.925 -31.315 -60.112 1.00 18.67 ? 299 TYR B N 1 ATOM 5177 C CA . TYR B 1 315 ? 17.923 -30.462 -59.513 1.00 22.49 ? 299 TYR B CA 1 ATOM 5178 C C . TYR B 1 315 ? 19.278 -31.126 -59.581 1.00 19.08 ? 299 TYR B C 1 ATOM 5179 O O . TYR B 1 315 ? 19.403 -32.316 -59.346 1.00 21.20 ? 299 TYR B O 1 ATOM 5180 C CB . TYR B 1 315 ? 17.565 -30.182 -58.063 1.00 21.04 ? 299 TYR B CB 1 ATOM 5181 C CG . TYR B 1 315 ? 16.412 -29.237 -57.905 1.00 20.25 ? 299 TYR B CG 1 ATOM 5182 C CD1 . TYR B 1 315 ? 16.581 -27.880 -58.104 1.00 21.04 ? 299 TYR B CD1 1 ATOM 5183 C CD2 . TYR B 1 315 ? 15.157 -29.697 -57.548 1.00 18.18 ? 299 TYR B CD2 1 ATOM 5184 C CE1 . TYR B 1 315 ? 15.537 -27.010 -57.952 1.00 22.59 ? 299 TYR B CE1 1 ATOM 5185 C CE2 . TYR B 1 315 ? 14.105 -28.833 -57.392 1.00 17.38 ? 299 TYR B CE2 1 ATOM 5186 C CZ . TYR B 1 315 ? 14.301 -27.492 -57.602 1.00 21.74 ? 299 TYR B CZ 1 ATOM 5187 O OH . TYR B 1 315 ? 13.264 -26.612 -57.444 1.00 21.66 ? 299 TYR B OH 1 ATOM 5188 N N . VAL B 1 316 ? 20.296 -30.345 -59.906 1.00 21.52 ? 300 VAL B N 1 ATOM 5189 C CA . VAL B 1 316 ? 21.662 -30.847 -59.896 1.00 22.69 ? 300 VAL B CA 1 ATOM 5190 C C . VAL B 1 316 ? 22.232 -30.741 -58.502 1.00 23.54 ? 300 VAL B C 1 ATOM 5191 O O . VAL B 1 316 ? 21.886 -29.832 -57.754 1.00 22.68 ? 300 VAL B O 1 ATOM 5192 C CB . VAL B 1 316 ? 22.590 -30.070 -60.853 1.00 26.95 ? 300 VAL B CB 1 ATOM 5193 C CG1 . VAL B 1 316 ? 22.172 -30.297 -62.305 1.00 25.83 ? 300 VAL B CG1 1 ATOM 5194 C CG2 . VAL B 1 316 ? 22.639 -28.564 -60.501 1.00 24.09 ? 300 VAL B CG2 1 ATOM 5195 N N . MET B 1 317 ? 23.101 -31.675 -58.147 1.00 23.58 ? 301 MET B N 1 ATOM 5196 C CA . MET B 1 317 ? 23.779 -31.601 -56.865 1.00 25.30 ? 301 MET B CA 1 ATOM 5197 C C . MET B 1 317 ? 24.624 -30.341 -56.830 1.00 24.60 ? 301 MET B C 1 ATOM 5198 O O . MET B 1 317 ? 25.345 -30.036 -57.776 1.00 27.81 ? 301 MET B O 1 ATOM 5199 C CB . MET B 1 317 ? 24.657 -32.835 -56.637 1.00 29.18 ? 301 MET B CB 1 ATOM 5200 C CG . MET B 1 317 ? 23.916 -34.192 -56.659 1.00 28.51 ? 301 MET B CG 1 ATOM 5201 S SD . MET B 1 317 ? 22.725 -34.496 -55.313 1.00 35.39 ? 301 MET B SD 1 ATOM 5202 C CE . MET B 1 317 ? 22.636 -36.285 -55.294 1.00 38.98 ? 301 MET B CE 1 ATOM 5203 N N . CYS B 1 318 ? 24.505 -29.589 -55.745 1.00 22.97 ? 302 CYS B N 1 ATOM 5204 C CA . CYS B 1 318 ? 25.340 -28.423 -55.540 1.00 22.64 ? 302 CYS B CA 1 ATOM 5205 C C . CYS B 1 318 ? 26.770 -28.855 -55.732 1.00 23.86 ? 302 CYS B C 1 ATOM 5206 O O . CYS B 1 318 ? 27.116 -29.991 -55.435 1.00 27.06 ? 302 CYS B O 1 ATOM 5207 C CB . CYS B 1 318 ? 25.141 -27.862 -54.134 1.00 22.34 ? 302 CYS B CB 1 ATOM 5208 S SG . CYS B 1 318 ? 23.451 -27.280 -53.814 1.00 23.90 ? 302 CYS B SG 1 ATOM 5209 N N . THR B 1 319 ? 27.598 -27.961 -56.248 1.00 24.46 ? 303 THR B N 1 ATOM 5210 C CA . THR B 1 319 ? 29.003 -28.275 -56.442 1.00 22.07 ? 303 THR B CA 1 ATOM 5211 C C . THR B 1 319 ? 29.852 -27.478 -55.461 1.00 22.45 ? 303 THR B C 1 ATOM 5212 O O . THR B 1 319 ? 30.930 -27.909 -55.069 1.00 29.38 ? 303 THR B O 1 ATOM 5213 C CB . THR B 1 319 ? 29.449 -27.989 -57.888 1.00 21.36 ? 303 THR B CB 1 ATOM 5214 O OG1 . THR B 1 319 ? 29.355 -26.590 -58.157 1.00 26.48 ? 303 THR B OG1 1 ATOM 5215 C CG2 . THR B 1 319 ? 28.587 -28.732 -58.878 1.00 24.06 ? 303 THR B CG2 1 ATOM 5216 N N . GLY B 1 320 ? 29.353 -26.321 -55.055 1.00 23.55 ? 304 GLY B N 1 ATOM 5217 C CA . GLY B 1 320 ? 30.099 -25.421 -54.200 1.00 24.06 ? 304 GLY B CA 1 ATOM 5218 C C . GLY B 1 320 ? 30.058 -25.719 -52.710 1.00 23.58 ? 304 GLY B C 1 ATOM 5219 O O . GLY B 1 320 ? 29.830 -26.847 -52.267 1.00 24.60 ? 304 GLY B O 1 ATOM 5220 N N . SER B 1 321 ? 30.275 -24.673 -51.931 1.00 23.54 ? 305 SER B N 1 ATOM 5221 C CA . SER B 1 321 ? 30.596 -24.815 -50.526 1.00 20.65 ? 305 SER B CA 1 ATOM 5222 C C . SER B 1 321 ? 29.448 -24.377 -49.651 1.00 20.40 ? 305 SER B C 1 ATOM 5223 O O . SER B 1 321 ? 28.656 -23.525 -50.043 1.00 17.40 ? 305 SER B O 1 ATOM 5224 C CB . SER B 1 321 ? 31.816 -23.951 -50.202 1.00 23.69 ? 305 SER B CB 1 ATOM 5225 O OG . SER B 1 321 ? 32.941 -24.341 -50.976 1.00 31.41 ? 305 SER B OG 1 ATOM 5226 N N . PHE B 1 322 ? 29.389 -24.954 -48.448 1.00 20.55 ? 306 PHE B N 1 ATOM 5227 C CA . PHE B 1 322 ? 28.409 -24.572 -47.436 1.00 18.12 ? 306 PHE B CA 1 ATOM 5228 C C . PHE B 1 322 ? 29.101 -24.052 -46.195 1.00 19.87 ? 306 PHE B C 1 ATOM 5229 O O . PHE B 1 322 ? 30.188 -24.489 -45.836 1.00 18.13 ? 306 PHE B O 1 ATOM 5230 C CB . PHE B 1 322 ? 27.514 -25.751 -47.055 1.00 16.50 ? 306 PHE B CB 1 ATOM 5231 C CG . PHE B 1 322 ? 26.763 -26.324 -48.210 1.00 16.30 ? 306 PHE B CG 1 ATOM 5232 C CD1 . PHE B 1 322 ? 27.355 -27.255 -49.028 1.00 17.16 ? 306 PHE B CD1 1 ATOM 5233 C CD2 . PHE B 1 322 ? 25.455 -25.938 -48.472 1.00 17.84 ? 306 PHE B CD2 1 ATOM 5234 C CE1 . PHE B 1 322 ? 26.677 -27.788 -50.090 1.00 18.95 ? 306 PHE B CE1 1 ATOM 5235 C CE2 . PHE B 1 322 ? 24.772 -26.465 -49.539 1.00 15.58 ? 306 PHE B CE2 1 ATOM 5236 C CZ . PHE B 1 322 ? 25.381 -27.396 -50.343 1.00 19.32 ? 306 PHE B CZ 1 ATOM 5237 N N . LYS B 1 323 ? 28.443 -23.111 -45.542 1.00 23.62 ? 307 LYS B N 1 ATOM 5238 C CA . LYS B 1 323 ? 28.971 -22.453 -44.374 1.00 18.90 ? 307 LYS B CA 1 ATOM 5239 C C . LYS B 1 323 ? 27.975 -22.728 -43.267 1.00 16.71 ? 307 LYS B C 1 ATOM 5240 O O . LYS B 1 323 ? 26.785 -22.744 -43.519 1.00 17.25 ? 307 LYS B O 1 ATOM 5241 C CB . LYS B 1 323 ? 29.092 -20.965 -44.691 1.00 21.53 ? 307 LYS B CB 1 ATOM 5242 C CG . LYS B 1 323 ? 29.156 -20.037 -43.500 1.00 28.46 ? 307 LYS B CG 1 ATOM 5243 C CD . LYS B 1 323 ? 29.489 -18.616 -43.946 1.00 32.61 ? 307 LYS B CD 1 ATOM 5244 C CE . LYS B 1 323 ? 29.611 -17.660 -42.760 1.00 44.27 ? 307 LYS B CE 1 ATOM 5245 N NZ . LYS B 1 323 ? 28.317 -16.987 -42.404 1.00 38.00 ? 307 LYS B NZ 1 ATOM 5246 N N . LEU B 1 324 ? 28.460 -22.985 -42.060 1.00 16.34 ? 308 LEU B N 1 ATOM 5247 C CA . LEU B 1 324 ? 27.605 -23.227 -40.889 1.00 14.87 ? 308 LEU B CA 1 ATOM 5248 C C . LEU B 1 324 ? 27.095 -21.926 -40.310 1.00 16.41 ? 308 LEU B C 1 ATOM 5249 O O . LEU B 1 324 ? 27.885 -21.027 -40.012 1.00 20.20 ? 308 LEU B O 1 ATOM 5250 C CB . LEU B 1 324 ? 28.391 -23.952 -39.796 1.00 12.68 ? 308 LEU B CB 1 ATOM 5251 C CG . LEU B 1 324 ? 27.572 -24.457 -38.628 1.00 12.24 ? 308 LEU B CG 1 ATOM 5252 C CD1 . LEU B 1 324 ? 26.653 -25.562 -39.126 1.00 14.40 ? 308 LEU B CD1 1 ATOM 5253 C CD2 . LEU B 1 324 ? 28.446 -24.983 -37.497 1.00 13.97 ? 308 LEU B CD2 1 ATOM 5254 N N . GLU B 1 325 ? 25.785 -21.820 -40.128 1.00 12.98 ? 309 GLU B N 1 ATOM 5255 C CA . GLU B 1 325 ? 25.179 -20.551 -39.723 1.00 15.65 ? 309 GLU B CA 1 ATOM 5256 C C . GLU B 1 325 ? 25.135 -20.379 -38.204 1.00 16.83 ? 309 GLU B C 1 ATOM 5257 O O . GLU B 1 325 ? 25.235 -19.273 -37.696 1.00 16.66 ? 309 GLU B O 1 ATOM 5258 C CB . GLU B 1 325 ? 23.763 -20.418 -40.284 1.00 17.82 ? 309 GLU B CB 1 ATOM 5259 C CG . GLU B 1 325 ? 23.680 -20.072 -41.754 1.00 17.73 ? 309 GLU B CG 1 ATOM 5260 C CD . GLU B 1 325 ? 24.203 -18.692 -42.051 1.00 26.38 ? 309 GLU B CD 1 ATOM 5261 O OE1 . GLU B 1 325 ? 25.426 -18.576 -42.278 1.00 27.61 ? 309 GLU B OE1 1 ATOM 5262 O OE2 . GLU B 1 325 ? 23.401 -17.728 -42.039 1.00 26.82 ? 309 GLU B OE2 1 ATOM 5263 N N . LYS B 1 326 ? 24.956 -21.480 -37.490 1.00 16.75 ? 310 LYS B N 1 ATOM 5264 C CA . LYS B 1 326 ? 25.008 -21.481 -36.039 1.00 14.44 ? 310 LYS B CA 1 ATOM 5265 C C . LYS B 1 326 ? 25.343 -22.920 -35.699 1.00 12.09 ? 310 LYS B C 1 ATOM 5266 O O . LYS B 1 326 ? 25.288 -23.769 -36.566 1.00 14.11 ? 310 LYS B O 1 ATOM 5267 C CB . LYS B 1 326 ? 23.686 -20.988 -35.414 1.00 13.59 ? 310 LYS B CB 1 ATOM 5268 C CG . LYS B 1 326 ? 22.445 -21.790 -35.772 1.00 18.33 ? 310 LYS B CG 1 ATOM 5269 C CD . LYS B 1 326 ? 21.122 -21.134 -35.300 1.00 18.48 ? 310 LYS B CD 1 ATOM 5270 C CE . LYS B 1 326 ? 21.095 -20.812 -33.804 1.00 30.04 ? 310 LYS B CE 1 ATOM 5271 N NZ . LYS B 1 326 ? 19.724 -20.461 -33.266 1.00 31.18 ? 310 LYS B NZ 1 ATOM 5272 N N . GLU B 1 327 ? 25.731 -23.206 -34.470 1.00 12.26 ? 311 GLU B N 1 ATOM 5273 C CA . GLU B 1 327 ? 26.151 -24.558 -34.143 1.00 14.41 ? 311 GLU B CA 1 ATOM 5274 C C . GLU B 1 327 ? 24.966 -25.516 -34.189 1.00 13.75 ? 311 GLU B C 1 ATOM 5275 O O . GLU B 1 327 ? 23.837 -25.088 -33.997 1.00 14.17 ? 311 GLU B O 1 ATOM 5276 C CB . GLU B 1 327 ? 26.780 -24.576 -32.769 1.00 19.20 ? 311 GLU B CB 1 ATOM 5277 C CG . GLU B 1 327 ? 25.879 -24.019 -31.726 1.00 21.07 ? 311 GLU B CG 1 ATOM 5278 C CD . GLU B 1 327 ? 26.317 -24.391 -30.347 1.00 20.84 ? 311 GLU B CD 1 ATOM 5279 O OE1 . GLU B 1 327 ? 25.486 -24.969 -29.619 1.00 28.06 ? 311 GLU B OE1 1 ATOM 5280 O OE2 . GLU B 1 327 ? 27.483 -24.104 -30.011 1.00 18.30 ? 311 GLU B OE2 1 ATOM 5281 N N . VAL B 1 328 ? 25.222 -26.802 -34.431 1.00 13.80 ? 312 VAL B N 1 ATOM 5282 C CA . VAL B 1 328 ? 24.150 -27.803 -34.533 1.00 14.03 ? 312 VAL B CA 1 ATOM 5283 C C . VAL B 1 328 ? 23.375 -27.884 -33.217 1.00 14.39 ? 312 VAL B C 1 ATOM 5284 O O . VAL B 1 328 ? 23.953 -27.796 -32.139 1.00 13.27 ? 312 VAL B O 1 ATOM 5285 C CB . VAL B 1 328 ? 24.692 -29.211 -34.909 1.00 13.71 ? 312 VAL B CB 1 ATOM 5286 C CG1 . VAL B 1 328 ? 23.592 -30.247 -34.857 1.00 9.31 ? 312 VAL B CG1 1 ATOM 5287 C CG2 . VAL B 1 328 ? 25.352 -29.183 -36.275 1.00 14.22 ? 312 VAL B CG2 1 ATOM 5288 N N . ALA B 1 329 ? 22.061 -28.048 -33.321 1.00 14.79 ? 313 ALA B N 1 ATOM 5289 C CA . ALA B 1 329 ? 21.167 -28.034 -32.165 1.00 16.43 ? 313 ALA B CA 1 ATOM 5290 C C . ALA B 1 329 ? 20.363 -29.322 -32.084 1.00 12.89 ? 313 ALA B C 1 ATOM 5291 O O . ALA B 1 329 ? 19.781 -29.727 -33.069 1.00 14.11 ? 313 ALA B O 1 ATOM 5292 C CB . ALA B 1 329 ? 20.214 -26.863 -32.275 1.00 16.98 ? 313 ALA B CB 1 ATOM 5293 N N . GLU B 1 330 ? 20.302 -29.936 -30.903 1.00 16.27 ? 314 GLU B N 1 ATOM 5294 C CA . GLU B 1 330 ? 19.530 -31.164 -30.716 1.00 15.45 ? 314 GLU B CA 1 ATOM 5295 C C . GLU B 1 330 ? 18.076 -30.876 -30.404 1.00 17.38 ? 314 GLU B C 1 ATOM 5296 O O . GLU B 1 330 ? 17.771 -29.843 -29.831 1.00 14.29 ? 314 GLU B O 1 ATOM 5297 C CB . GLU B 1 330 ? 20.101 -31.967 -29.558 1.00 16.43 ? 314 GLU B CB 1 ATOM 5298 C CG . GLU B 1 330 ? 19.924 -31.342 -28.210 1.00 21.04 ? 314 GLU B CG 1 ATOM 5299 C CD . GLU B 1 330 ? 20.462 -32.213 -27.106 1.00 26.48 ? 314 GLU B CD 1 ATOM 5300 O OE1 . GLU B 1 330 ? 20.447 -31.765 -25.942 1.00 27.35 ? 314 GLU B OE1 1 ATOM 5301 O OE2 . GLU B 1 330 ? 20.914 -33.345 -27.403 1.00 30.26 ? 314 GLU B OE2 1 ATOM 5302 N N . THR B 1 331 ? 17.182 -31.792 -30.768 1.00 20.10 ? 315 THR B N 1 ATOM 5303 C CA . THR B 1 331 ? 15.820 -31.778 -30.231 1.00 14.74 ? 315 THR B CA 1 ATOM 5304 C C . THR B 1 331 ? 15.809 -32.687 -29.025 1.00 14.97 ? 315 THR B C 1 ATOM 5305 O O . THR B 1 331 ? 16.867 -33.136 -28.581 1.00 16.46 ? 315 THR B O 1 ATOM 5306 C CB . THR B 1 331 ? 14.763 -32.258 -31.249 1.00 11.24 ? 315 THR B CB 1 ATOM 5307 O OG1 . THR B 1 331 ? 14.958 -33.643 -31.539 1.00 12.88 ? 315 THR B OG1 1 ATOM 5308 C CG2 . THR B 1 331 ? 14.857 -31.464 -32.535 1.00 17.34 ? 315 THR B CG2 1 ATOM 5309 N N . GLN B 1 332 ? 14.637 -32.969 -28.472 1.00 12.66 ? 316 GLN B N 1 ATOM 5310 C CA . GLN B 1 332 ? 14.600 -33.951 -27.412 1.00 13.36 ? 316 GLN B CA 1 ATOM 5311 C C . GLN B 1 332 ? 14.052 -35.298 -27.865 1.00 15.49 ? 316 GLN B C 1 ATOM 5312 O O . GLN B 1 332 ? 13.866 -36.193 -27.039 1.00 15.62 ? 316 GLN B O 1 ATOM 5313 C CB . GLN B 1 332 ? 13.857 -33.425 -26.189 1.00 13.85 ? 316 GLN B CB 1 ATOM 5314 C CG . GLN B 1 332 ? 14.697 -32.472 -25.345 1.00 16.61 ? 316 GLN B CG 1 ATOM 5315 C CD . GLN B 1 332 ? 16.009 -33.088 -24.879 1.00 22.71 ? 316 GLN B CD 1 ATOM 5316 O OE1 . GLN B 1 332 ? 16.023 -34.104 -24.179 1.00 23.77 ? 316 GLN B OE1 1 ATOM 5317 N NE2 . GLN B 1 332 ? 17.121 -32.478 -25.274 1.00 24.05 ? 316 GLN B NE2 1 ATOM 5318 N N . HIS B 1 333 ? 13.830 -35.451 -29.171 1.00 12.92 ? 317 HIS B N 1 ATOM 5319 C CA . HIS B 1 333 ? 13.393 -36.725 -29.717 1.00 9.34 ? 317 HIS B CA 1 ATOM 5320 C C . HIS B 1 333 ? 14.399 -37.324 -30.692 1.00 11.27 ? 317 HIS B C 1 ATOM 5321 O O . HIS B 1 333 ? 14.008 -37.964 -31.666 1.00 12.35 ? 317 HIS B O 1 ATOM 5322 C CB . HIS B 1 333 ? 11.986 -36.621 -30.347 1.00 10.20 ? 317 HIS B CB 1 ATOM 5323 C CG . HIS B 1 333 ? 11.828 -35.528 -31.360 1.00 11.79 ? 317 HIS B CG 1 ATOM 5324 N ND1 . HIS B 1 333 ? 11.861 -35.771 -32.735 1.00 15.40 ? 317 HIS B ND1 1 ATOM 5325 C CD2 . HIS B 1 333 ? 11.606 -34.215 -31.250 1.00 10.98 ? 317 HIS B CD2 1 ATOM 5326 C CE1 . HIS B 1 333 ? 11.678 -34.661 -33.389 1.00 13.28 ? 317 HIS B CE1 1 ATOM 5327 N NE2 . HIS B 1 333 ? 11.519 -33.664 -32.495 1.00 15.48 ? 317 HIS B NE2 1 ATOM 5328 N N . GLY B 1 334 ? 15.689 -37.126 -30.424 1.00 8.49 ? 318 GLY B N 1 ATOM 5329 C CA . GLY B 1 334 ? 16.732 -37.858 -31.122 1.00 9.33 ? 318 GLY B CA 1 ATOM 5330 C C . GLY B 1 334 ? 17.192 -37.273 -32.442 1.00 8.33 ? 318 GLY B C 1 ATOM 5331 O O . GLY B 1 334 ? 18.007 -37.871 -33.145 1.00 9.16 ? 318 GLY B O 1 ATOM 5332 N N . THR B 1 335 ? 16.668 -36.102 -32.782 1.00 10.82 ? 319 THR B N 1 ATOM 5333 C CA . THR B 1 335 ? 17.039 -35.416 -34.016 1.00 10.07 ? 319 THR B CA 1 ATOM 5334 C C . THR B 1 335 ? 17.937 -34.192 -33.735 1.00 9.44 ? 319 THR B C 1 ATOM 5335 O O . THR B 1 335 ? 18.111 -33.771 -32.582 1.00 10.71 ? 319 THR B O 1 ATOM 5336 C CB . THR B 1 335 ? 15.791 -35.032 -34.841 1.00 7.73 ? 319 THR B CB 1 ATOM 5337 O OG1 . THR B 1 335 ? 15.114 -33.945 -34.222 1.00 10.61 ? 319 THR B OG1 1 ATOM 5338 C CG2 . THR B 1 335 ? 14.844 -36.197 -34.946 1.00 8.13 ? 319 THR B CG2 1 ATOM 5339 N N . VAL B 1 336 ? 18.526 -33.655 -34.802 1.00 9.98 ? 320 VAL B N 1 ATOM 5340 C CA . VAL B 1 336 ? 19.427 -32.511 -34.733 1.00 10.17 ? 320 VAL B CA 1 ATOM 5341 C C . VAL B 1 336 ? 19.074 -31.555 -35.856 1.00 9.09 ? 320 VAL B C 1 ATOM 5342 O O . VAL B 1 336 ? 18.696 -31.987 -36.938 1.00 8.05 ? 320 VAL B O 1 ATOM 5343 C CB . VAL B 1 336 ? 20.936 -32.933 -34.852 1.00 10.61 ? 320 VAL B CB 1 ATOM 5344 C CG1 . VAL B 1 336 ? 21.321 -33.900 -33.747 1.00 11.13 ? 320 VAL B CG1 1 ATOM 5345 C CG2 . VAL B 1 336 ? 21.245 -33.549 -36.205 1.00 8.30 ? 320 VAL B CG2 1 ATOM 5346 N N . LEU B 1 337 ? 19.192 -30.254 -35.598 1.00 14.06 ? 321 LEU B N 1 ATOM 5347 C CA . LEU B 1 337 ? 18.939 -29.235 -36.625 1.00 10.90 ? 321 LEU B CA 1 ATOM 5348 C C . LEU B 1 337 ? 20.234 -28.533 -37.056 1.00 11.30 ? 321 LEU B C 1 ATOM 5349 O O . LEU B 1 337 ? 20.955 -27.972 -36.243 1.00 11.07 ? 321 LEU B O 1 ATOM 5350 C CB . LEU B 1 337 ? 17.931 -28.177 -36.133 1.00 13.86 ? 321 LEU B CB 1 ATOM 5351 C CG . LEU B 1 337 ? 16.629 -28.504 -35.364 1.00 11.81 ? 321 LEU B CG 1 ATOM 5352 C CD1 . LEU B 1 337 ? 15.691 -29.511 -36.062 1.00 11.34 ? 321 LEU B CD1 1 ATOM 5353 C CD2 . LEU B 1 337 ? 16.949 -28.958 -33.967 1.00 18.93 ? 321 LEU B CD2 1 ATOM 5354 N N . VAL B 1 338 ? 20.506 -28.568 -38.350 1.00 12.57 ? 322 VAL B N 1 ATOM 5355 C CA . VAL B 1 338 ? 21.719 -28.008 -38.921 1.00 11.55 ? 322 VAL B CA 1 ATOM 5356 C C . VAL B 1 338 ? 21.336 -26.886 -39.886 1.00 11.31 ? 322 VAL B C 1 ATOM 5357 O O . VAL B 1 338 ? 20.660 -27.142 -40.856 1.00 13.40 ? 322 VAL B O 1 ATOM 5358 C CB . VAL B 1 338 ? 22.475 -29.118 -39.679 1.00 13.13 ? 322 VAL B CB 1 ATOM 5359 C CG1 . VAL B 1 338 ? 23.672 -28.583 -40.445 1.00 9.50 ? 322 VAL B CG1 1 ATOM 5360 C CG2 . VAL B 1 338 ? 22.886 -30.232 -38.707 1.00 10.80 ? 322 VAL B CG2 1 ATOM 5361 N N . GLN B 1 339 ? 21.759 -25.648 -39.620 1.00 13.13 ? 323 GLN B N 1 ATOM 5362 C CA . GLN B 1 339 ? 21.495 -24.517 -40.530 1.00 12.19 ? 323 GLN B CA 1 ATOM 5363 C C . GLN B 1 339 ? 22.748 -24.039 -41.262 1.00 11.64 ? 323 GLN B C 1 ATOM 5364 O O . GLN B 1 339 ? 23.711 -23.621 -40.648 1.00 14.02 ? 323 GLN B O 1 ATOM 5365 C CB . GLN B 1 339 ? 20.890 -23.339 -39.778 1.00 11.64 ? 323 GLN B CB 1 ATOM 5366 C CG . GLN B 1 339 ? 20.479 -22.149 -40.670 1.00 13.52 ? 323 GLN B CG 1 ATOM 5367 C CD . GLN B 1 339 ? 19.880 -21.003 -39.865 1.00 16.41 ? 323 GLN B CD 1 ATOM 5368 O OE1 . GLN B 1 339 ? 20.557 -20.027 -39.553 1.00 24.05 ? 323 GLN B OE1 1 ATOM 5369 N NE2 . GLN B 1 339 ? 18.617 -21.126 -39.512 1.00 13.90 ? 323 GLN B NE2 1 ATOM 5370 N N . VAL B 1 340 ? 22.724 -24.111 -42.583 1.00 13.91 ? 324 VAL B N 1 ATOM 5371 C CA . VAL B 1 340 ? 23.902 -23.837 -43.380 1.00 12.64 ? 324 VAL B CA 1 ATOM 5372 C C . VAL B 1 340 ? 23.583 -22.790 -44.449 1.00 14.74 ? 324 VAL B C 1 ATOM 5373 O O . VAL B 1 340 ? 22.427 -22.469 -44.699 1.00 15.10 ? 324 VAL B O 1 ATOM 5374 C CB . VAL B 1 340 ? 24.436 -25.136 -44.012 1.00 13.59 ? 324 VAL B CB 1 ATOM 5375 C CG1 . VAL B 1 340 ? 25.028 -26.047 -42.944 1.00 12.72 ? 324 VAL B CG1 1 ATOM 5376 C CG2 . VAL B 1 340 ? 23.328 -25.854 -44.783 1.00 17.91 ? 324 VAL B CG2 1 ATOM 5377 N N . LYS B 1 341 ? 24.618 -22.237 -45.060 1.00 15.84 ? 325 LYS B N 1 ATOM 5378 C CA . LYS B 1 341 ? 24.449 -21.311 -46.179 1.00 17.89 ? 325 LYS B CA 1 ATOM 5379 C C . LYS B 1 341 ? 25.375 -21.691 -47.341 1.00 15.12 ? 325 LYS B C 1 ATOM 5380 O O . LYS B 1 341 ? 26.570 -21.927 -47.148 1.00 18.70 ? 325 LYS B O 1 ATOM 5381 C CB . LYS B 1 341 ? 24.727 -19.874 -45.725 1.00 21.38 ? 325 LYS B CB 1 ATOM 5382 C CG . LYS B 1 341 ? 23.540 -18.926 -45.835 1.00 21.62 ? 325 LYS B CG 1 ATOM 5383 C CD . LYS B 1 341 ? 24.009 -17.521 -46.184 1.00 28.62 ? 325 LYS B CD 1 ATOM 5384 C CE . LYS B 1 341 ? 22.902 -16.493 -46.041 1.00 29.40 ? 325 LYS B CE 1 ATOM 5385 N NZ . LYS B 1 341 ? 23.400 -15.109 -46.313 1.00 31.21 ? 325 LYS B NZ 1 ATOM 5386 N N . TYR B 1 342 ? 24.815 -21.748 -48.548 1.00 20.29 ? 326 TYR B N 1 ATOM 5387 C CA . TYR B 1 342 ? 25.550 -22.171 -49.746 1.00 20.90 ? 326 TYR B CA 1 ATOM 5388 C C . TYR B 1 342 ? 26.402 -21.036 -50.338 1.00 24.02 ? 326 TYR B C 1 ATOM 5389 O O . TYR B 1 342 ? 26.007 -19.868 -50.315 1.00 19.61 ? 326 TYR B O 1 ATOM 5390 C CB . TYR B 1 342 ? 24.568 -22.697 -50.797 1.00 17.25 ? 326 TYR B CB 1 ATOM 5391 C CG . TYR B 1 342 ? 25.213 -23.367 -51.978 1.00 17.57 ? 326 TYR B CG 1 ATOM 5392 C CD1 . TYR B 1 342 ? 26.140 -24.380 -51.799 1.00 19.42 ? 326 TYR B CD1 1 ATOM 5393 C CD2 . TYR B 1 342 ? 24.877 -23.006 -53.275 1.00 21.55 ? 326 TYR B CD2 1 ATOM 5394 C CE1 . TYR B 1 342 ? 26.731 -25.001 -52.869 1.00 22.18 ? 326 TYR B CE1 1 ATOM 5395 C CE2 . TYR B 1 342 ? 25.470 -23.617 -54.358 1.00 21.99 ? 326 TYR B CE2 1 ATOM 5396 C CZ . TYR B 1 342 ? 26.393 -24.616 -54.149 1.00 23.28 ? 326 TYR B CZ 1 ATOM 5397 O OH . TYR B 1 342 ? 26.982 -25.241 -55.218 1.00 29.35 ? 326 TYR B OH 1 ATOM 5398 N N . GLU B 1 343 ? 27.574 -21.393 -50.857 1.00 24.73 ? 327 GLU B N 1 ATOM 5399 C CA . GLU B 1 343 ? 28.499 -20.412 -51.395 1.00 24.24 ? 327 GLU B CA 1 ATOM 5400 C C . GLU B 1 343 ? 28.767 -20.621 -52.872 1.00 28.52 ? 327 GLU B C 1 ATOM 5401 O O . GLU B 1 343 ? 29.394 -19.774 -53.496 1.00 30.15 ? 327 GLU B O 1 ATOM 5402 C CB . GLU B 1 343 ? 29.797 -20.477 -50.627 1.00 25.16 ? 327 GLU B CB 1 ATOM 5403 C CG . GLU B 1 343 ? 29.570 -20.476 -49.145 1.00 22.51 ? 327 GLU B CG 1 ATOM 5404 C CD . GLU B 1 343 ? 30.856 -20.519 -48.375 1.00 28.80 ? 327 GLU B CD 1 ATOM 5405 O OE1 . GLU B 1 343 ? 31.130 -19.564 -47.627 1.00 38.29 ? 327 GLU B OE1 1 ATOM 5406 O OE2 . GLU B 1 343 ? 31.602 -21.505 -48.522 1.00 31.14 ? 327 GLU B OE2 1 ATOM 5407 N N . GLY B 1 344 ? 28.276 -21.735 -53.424 1.00 30.21 ? 328 GLY B N 1 ATOM 5408 C CA . GLY B 1 344 ? 28.472 -22.100 -54.823 1.00 26.65 ? 328 GLY B CA 1 ATOM 5409 C C . GLY B 1 344 ? 27.729 -21.176 -55.762 1.00 28.31 ? 328 GLY B C 1 ATOM 5410 O O . GLY B 1 344 ? 27.344 -20.083 -55.363 1.00 34.22 ? 328 GLY B O 1 ATOM 5411 N N . THR B 1 345 ? 27.534 -21.588 -57.009 1.00 29.98 ? 329 THR B N 1 ATOM 5412 C CA . THR B 1 345 ? 26.956 -20.693 -58.013 1.00 30.18 ? 329 THR B CA 1 ATOM 5413 C C . THR B 1 345 ? 25.824 -21.330 -58.798 1.00 29.49 ? 329 THR B C 1 ATOM 5414 O O . THR B 1 345 ? 25.276 -20.707 -59.705 1.00 31.71 ? 329 THR B O 1 ATOM 5415 C CB . THR B 1 345 ? 28.006 -20.258 -59.043 1.00 26.42 ? 329 THR B CB 1 ATOM 5416 O OG1 . THR B 1 345 ? 28.398 -21.394 -59.820 1.00 28.64 ? 329 THR B OG1 1 ATOM 5417 C CG2 . THR B 1 345 ? 29.225 -19.664 -58.356 1.00 28.15 ? 329 THR B CG2 1 ATOM 5418 N N . ASP B 1 346 ? 25.450 -22.550 -58.430 1.00 27.91 ? 330 ASP B N 1 ATOM 5419 C CA . ASP B 1 346 ? 24.522 -23.347 -59.230 1.00 25.68 ? 330 ASP B CA 1 ATOM 5420 C C . ASP B 1 346 ? 23.100 -23.456 -58.656 1.00 23.42 ? 330 ASP B C 1 ATOM 5421 O O . ASP B 1 346 ? 22.360 -24.361 -59.027 1.00 25.74 ? 330 ASP B O 1 ATOM 5422 C CB . ASP B 1 346 ? 25.094 -24.749 -59.430 1.00 28.93 ? 330 ASP B CB 1 ATOM 5423 C CG . ASP B 1 346 ? 25.782 -25.278 -58.193 1.00 25.12 ? 330 ASP B CG 1 ATOM 5424 O OD1 . ASP B 1 346 ? 26.103 -24.455 -57.312 1.00 28.75 ? 330 ASP B OD1 1 ATOM 5425 O OD2 . ASP B 1 346 ? 26.021 -26.505 -58.113 1.00 26.85 ? 330 ASP B OD2 1 ATOM 5426 N N . ALA B 1 347 ? 22.701 -22.518 -57.802 1.00 23.41 ? 331 ALA B N 1 ATOM 5427 C CA . ALA B 1 347 ? 21.380 -22.566 -57.191 1.00 24.13 ? 331 ALA B CA 1 ATOM 5428 C C . ALA B 1 347 ? 20.355 -22.254 -58.262 1.00 24.99 ? 331 ALA B C 1 ATOM 5429 O O . ALA B 1 347 ? 20.550 -21.344 -59.050 1.00 24.77 ? 331 ALA B O 1 ATOM 5430 C CB . ALA B 1 347 ? 21.269 -21.581 -56.046 1.00 21.03 ? 331 ALA B CB 1 ATOM 5431 N N . PRO B 1 348 ? 19.236 -22.989 -58.275 1.00 28.02 ? 332 PRO B N 1 ATOM 5432 C CA . PRO B 1 348 ? 18.835 -23.954 -57.251 1.00 23.28 ? 332 PRO B CA 1 ATOM 5433 C C . PRO B 1 348 ? 19.378 -25.351 -57.470 1.00 19.86 ? 332 PRO B C 1 ATOM 5434 O O . PRO B 1 348 ? 19.288 -25.861 -58.572 1.00 21.23 ? 332 PRO B O 1 ATOM 5435 C CB . PRO B 1 348 ? 17.313 -23.967 -57.394 1.00 24.61 ? 332 PRO B CB 1 ATOM 5436 C CG . PRO B 1 348 ? 17.098 -23.787 -58.855 1.00 25.79 ? 332 PRO B CG 1 ATOM 5437 C CD . PRO B 1 348 ? 18.192 -22.835 -59.305 1.00 31.55 ? 332 PRO B CD 1 ATOM 5438 N N . CYS B 1 349 ? 19.895 -25.964 -56.411 1.00 18.08 ? 333 CYS B N 1 ATOM 5439 C CA . CYS B 1 349 ? 20.482 -27.288 -56.498 1.00 19.25 ? 333 CYS B CA 1 ATOM 5440 C C . CYS B 1 349 ? 20.207 -28.086 -55.233 1.00 18.20 ? 333 CYS B C 1 ATOM 5441 O O . CYS B 1 349 ? 19.749 -27.560 -54.229 1.00 17.43 ? 333 CYS B O 1 ATOM 5442 C CB . CYS B 1 349 ? 21.982 -27.175 -56.701 1.00 18.44 ? 333 CYS B CB 1 ATOM 5443 S SG . CYS B 1 349 ? 22.774 -26.212 -55.423 1.00 23.55 ? 333 CYS B SG 1 ATOM 5444 N N . LYS B 1 350 ? 20.505 -29.369 -55.288 1.00 18.05 ? 334 LYS B N 1 ATOM 5445 C CA . LYS B 1 350 ? 20.193 -30.260 -54.201 1.00 15.77 ? 334 LYS B CA 1 ATOM 5446 C C . LYS B 1 350 ? 21.417 -30.360 -53.313 1.00 18.22 ? 334 LYS B C 1 ATOM 5447 O O . LYS B 1 350 ? 22.539 -30.434 -53.797 1.00 17.96 ? 334 LYS B O 1 ATOM 5448 C CB . LYS B 1 350 ? 19.792 -31.621 -54.764 1.00 18.74 ? 334 LYS B CB 1 ATOM 5449 C CG . LYS B 1 350 ? 19.080 -32.535 -53.790 1.00 23.74 ? 334 LYS B CG 1 ATOM 5450 C CD . LYS B 1 350 ? 18.319 -33.623 -54.523 1.00 28.15 ? 334 LYS B CD 1 ATOM 5451 C CE . LYS B 1 350 ? 17.832 -34.699 -53.569 1.00 32.45 ? 334 LYS B CE 1 ATOM 5452 N NZ . LYS B 1 350 ? 17.110 -35.824 -54.261 1.00 40.00 ? 334 LYS B NZ 1 ATOM 5453 N N . ILE B 1 351 ? 21.190 -30.330 -52.007 1.00 16.49 ? 335 ILE B N 1 ATOM 5454 C CA . ILE B 1 351 ? 22.257 -30.375 -51.020 1.00 15.67 ? 335 ILE B CA 1 ATOM 5455 C C . ILE B 1 351 ? 22.771 -31.801 -50.795 1.00 17.26 ? 335 ILE B C 1 ATOM 5456 O O . ILE B 1 351 ? 22.014 -32.716 -50.441 1.00 15.48 ? 335 ILE B O 1 ATOM 5457 C CB . ILE B 1 351 ? 21.780 -29.772 -49.680 1.00 14.74 ? 335 ILE B CB 1 ATOM 5458 C CG1 . ILE B 1 351 ? 21.226 -28.366 -49.919 1.00 13.44 ? 335 ILE B CG1 1 ATOM 5459 C CG2 . ILE B 1 351 ? 22.923 -29.764 -48.634 1.00 15.33 ? 335 ILE B CG2 1 ATOM 5460 C CD1 . ILE B 1 351 ? 20.686 -27.661 -48.696 1.00 13.68 ? 335 ILE B CD1 1 ATOM 5461 N N . PRO B 1 352 ? 24.072 -32.004 -51.014 1.00 16.70 ? 336 PRO B N 1 ATOM 5462 C CA . PRO B 1 352 ? 24.664 -33.289 -50.636 1.00 17.17 ? 336 PRO B CA 1 ATOM 5463 C C . PRO B 1 352 ? 24.695 -33.488 -49.117 1.00 13.71 ? 336 PRO B C 1 ATOM 5464 O O . PRO B 1 352 ? 25.162 -32.612 -48.395 1.00 14.65 ? 336 PRO B O 1 ATOM 5465 C CB . PRO B 1 352 ? 26.079 -33.190 -51.212 1.00 17.64 ? 336 PRO B CB 1 ATOM 5466 C CG . PRO B 1 352 ? 25.952 -32.218 -52.338 1.00 15.49 ? 336 PRO B CG 1 ATOM 5467 C CD . PRO B 1 352 ? 24.995 -31.200 -51.826 1.00 16.38 ? 336 PRO B CD 1 ATOM 5468 N N . PHE B 1 353 ? 24.180 -34.628 -48.659 1.00 15.37 ? 337 PHE B N 1 ATOM 5469 C CA . PHE B 1 353 ? 24.162 -34.991 -47.243 1.00 17.74 ? 337 PHE B CA 1 ATOM 5470 C C . PHE B 1 353 ? 24.645 -36.419 -47.020 1.00 14.78 ? 337 PHE B C 1 ATOM 5471 O O . PHE B 1 353 ? 24.335 -37.316 -47.792 1.00 13.51 ? 337 PHE B O 1 ATOM 5472 C CB . PHE B 1 353 ? 22.749 -34.856 -46.667 1.00 14.23 ? 337 PHE B CB 1 ATOM 5473 C CG . PHE B 1 353 ? 22.604 -35.431 -45.291 1.00 12.49 ? 337 PHE B CG 1 ATOM 5474 C CD1 . PHE B 1 353 ? 22.387 -36.792 -45.114 1.00 17.02 ? 337 PHE B CD1 1 ATOM 5475 C CD2 . PHE B 1 353 ? 22.674 -34.620 -44.181 1.00 11.29 ? 337 PHE B CD2 1 ATOM 5476 C CE1 . PHE B 1 353 ? 22.250 -37.338 -43.859 1.00 12.61 ? 337 PHE B CE1 1 ATOM 5477 C CE2 . PHE B 1 353 ? 22.534 -35.162 -42.924 1.00 12.57 ? 337 PHE B CE2 1 ATOM 5478 C CZ . PHE B 1 353 ? 22.322 -36.534 -42.768 1.00 13.89 ? 337 PHE B CZ 1 ATOM 5479 N N . SER B 1 354 ? 25.411 -36.612 -45.955 1.00 14.47 ? 338 SER B N 1 ATOM 5480 C CA . SER B 1 354 ? 25.907 -37.928 -45.573 1.00 16.84 ? 338 SER B CA 1 ATOM 5481 C C . SER B 1 354 ? 25.981 -38.029 -44.057 1.00 14.13 ? 338 SER B C 1 ATOM 5482 O O . SER B 1 354 ? 26.195 -37.037 -43.372 1.00 14.01 ? 338 SER B O 1 ATOM 5483 C CB . SER B 1 354 ? 27.294 -38.182 -46.186 1.00 19.56 ? 338 SER B CB 1 ATOM 5484 O OG . SER B 1 354 ? 27.505 -39.562 -46.448 1.00 25.49 ? 338 SER B OG 1 ATOM 5485 N N . SER B 1 355 ? 25.790 -39.238 -43.548 1.00 15.58 ? 339 SER B N 1 ATOM 5486 C CA . SER B 1 355 ? 25.911 -39.535 -42.130 1.00 14.07 ? 339 SER B CA 1 ATOM 5487 C C . SER B 1 355 ? 26.920 -40.665 -41.959 1.00 14.65 ? 339 SER B C 1 ATOM 5488 O O . SER B 1 355 ? 26.825 -41.657 -42.653 1.00 12.97 ? 339 SER B O 1 ATOM 5489 C CB . SER B 1 355 ? 24.545 -39.955 -41.584 1.00 11.04 ? 339 SER B CB 1 ATOM 5490 O OG . SER B 1 355 ? 24.555 -40.127 -40.184 1.00 12.22 ? 339 SER B OG 1 ATOM 5491 N N . GLN B 1 356 ? 27.895 -40.517 -41.058 1.00 14.27 ? 340 GLN B N 1 ATOM 5492 C CA . GLN B 1 356 ? 28.776 -41.637 -40.684 1.00 16.00 ? 340 GLN B CA 1 ATOM 5493 C C . GLN B 1 356 ? 28.770 -41.854 -39.195 1.00 15.24 ? 340 GLN B C 1 ATOM 5494 O O . GLN B 1 356 ? 28.598 -40.916 -38.440 1.00 14.51 ? 340 GLN B O 1 ATOM 5495 C CB . GLN B 1 356 ? 30.216 -41.391 -41.105 1.00 20.94 ? 340 GLN B CB 1 ATOM 5496 C CG . GLN B 1 356 ? 30.500 -41.721 -42.535 1.00 22.61 ? 340 GLN B CG 1 ATOM 5497 C CD . GLN B 1 356 ? 30.318 -40.526 -43.439 1.00 26.08 ? 340 GLN B CD 1 ATOM 5498 O OE1 . GLN B 1 356 ? 29.595 -40.588 -44.440 1.00 28.32 ? 340 GLN B OE1 1 ATOM 5499 N NE2 . GLN B 1 356 ? 30.986 -39.430 -43.103 1.00 27.71 ? 340 GLN B NE2 1 ATOM 5500 N N . ASP B 1 357 ? 28.987 -43.086 -38.764 1.00 18.71 ? 341 ASP B N 1 ATOM 5501 C CA . ASP B 1 357 ? 28.916 -43.400 -37.345 1.00 23.77 ? 341 ASP B CA 1 ATOM 5502 C C . ASP B 1 357 ? 30.288 -43.485 -36.704 1.00 23.52 ? 341 ASP B C 1 ATOM 5503 O O . ASP B 1 357 ? 31.290 -43.284 -37.372 1.00 29.36 ? 341 ASP B O 1 ATOM 5504 C CB . ASP B 1 357 ? 28.196 -44.724 -37.148 1.00 25.64 ? 341 ASP B CB 1 ATOM 5505 C CG . ASP B 1 357 ? 29.006 -45.895 -37.631 1.00 25.20 ? 341 ASP B CG 1 ATOM 5506 O OD1 . ASP B 1 357 ? 30.166 -45.690 -38.044 1.00 26.71 ? 341 ASP B OD1 1 ATOM 5507 O OD2 . ASP B 1 357 ? 28.482 -47.021 -37.577 1.00 27.29 ? 341 ASP B OD2 1 ATOM 5508 N N . GLU B 1 358 ? 30.310 -43.825 -35.414 1.00 27.37 ? 342 GLU B N 1 ATOM 5509 C CA . GLU B 1 358 ? 31.538 -43.883 -34.611 1.00 28.25 ? 342 GLU B CA 1 ATOM 5510 C C . GLU B 1 358 ? 32.691 -44.537 -35.336 1.00 30.29 ? 342 GLU B C 1 ATOM 5511 O O . GLU B 1 358 ? 33.846 -44.227 -35.053 1.00 33.26 ? 342 GLU B O 1 ATOM 5512 C CB . GLU B 1 358 ? 31.301 -44.670 -33.321 1.00 30.62 ? 342 GLU B CB 1 ATOM 5513 C CG . GLU B 1 358 ? 30.946 -46.136 -33.547 1.00 34.34 ? 342 GLU B CG 1 ATOM 5514 C CD . GLU B 1 358 ? 29.502 -46.466 -33.189 1.00 39.61 ? 342 GLU B CD 1 ATOM 5515 O OE1 . GLU B 1 358 ? 28.891 -47.295 -33.903 1.00 45.43 ? 342 GLU B OE1 1 ATOM 5516 O OE2 . GLU B 1 358 ? 28.977 -45.910 -32.199 1.00 33.64 ? 342 GLU B OE2 1 ATOM 5517 N N . LYS B 1 359 ? 32.368 -45.455 -36.250 1.00 33.38 ? 343 LYS B N 1 ATOM 5518 C CA . LYS B 1 359 ? 33.376 -46.215 -36.985 1.00 33.63 ? 343 LYS B CA 1 ATOM 5519 C C . LYS B 1 359 ? 33.569 -45.734 -38.423 1.00 27.65 ? 343 LYS B C 1 ATOM 5520 O O . LYS B 1 359 ? 34.444 -46.236 -39.122 1.00 29.00 ? 343 LYS B O 1 ATOM 5521 C CB . LYS B 1 359 ? 33.038 -47.707 -36.965 1.00 36.45 ? 343 LYS B CB 1 ATOM 5522 N N . GLY B 1 360 ? 32.756 -44.775 -38.857 1.00 24.68 ? 344 GLY B N 1 ATOM 5523 C CA . GLY B 1 360 ? 32.944 -44.132 -40.145 1.00 26.21 ? 344 GLY B CA 1 ATOM 5524 C C . GLY B 1 360 ? 32.115 -44.749 -41.256 1.00 26.79 ? 344 GLY B C 1 ATOM 5525 O O . GLY B 1 360 ? 32.250 -44.371 -42.424 1.00 28.53 ? 344 GLY B O 1 ATOM 5526 N N . VAL B 1 361 ? 31.263 -45.703 -40.886 1.00 24.45 ? 345 VAL B N 1 ATOM 5527 C CA . VAL B 1 361 ? 30.310 -46.303 -41.814 1.00 24.88 ? 345 VAL B CA 1 ATOM 5528 C C . VAL B 1 361 ? 29.287 -45.270 -42.288 1.00 24.61 ? 345 VAL B C 1 ATOM 5529 O O . VAL B 1 361 ? 28.648 -44.611 -41.471 1.00 20.77 ? 345 VAL B O 1 ATOM 5530 C CB . VAL B 1 361 ? 29.535 -47.449 -41.138 1.00 23.61 ? 345 VAL B CB 1 ATOM 5531 C CG1 . VAL B 1 361 ? 28.557 -48.094 -42.114 1.00 22.69 ? 345 VAL B CG1 1 ATOM 5532 C CG2 . VAL B 1 361 ? 30.488 -48.485 -40.588 1.00 22.50 ? 345 VAL B CG2 1 ATOM 5533 N N . THR B 1 362 ? 29.125 -45.145 -43.602 1.00 25.59 ? 346 THR B N 1 ATOM 5534 C CA . THR B 1 362 ? 28.106 -44.264 -44.174 1.00 21.00 ? 346 THR B CA 1 ATOM 5535 C C . THR B 1 362 ? 26.736 -44.907 -44.010 1.00 18.19 ? 346 THR B C 1 ATOM 5536 O O . THR B 1 362 ? 26.556 -46.078 -44.308 1.00 21.03 ? 346 THR B O 1 ATOM 5537 C CB . THR B 1 362 ? 28.385 -43.976 -45.645 1.00 21.76 ? 346 THR B CB 1 ATOM 5538 O OG1 . THR B 1 362 ? 29.742 -43.550 -45.771 1.00 32.14 ? 346 THR B OG1 1 ATOM 5539 C CG2 . THR B 1 362 ? 27.475 -42.876 -46.182 1.00 19.25 ? 346 THR B CG2 1 ATOM 5540 N N . GLN B 1 363 ? 25.772 -44.125 -43.540 1.00 16.17 ? 347 GLN B N 1 ATOM 5541 C CA . GLN B 1 363 ? 24.504 -44.656 -43.077 1.00 11.70 ? 347 GLN B CA 1 ATOM 5542 C C . GLN B 1 363 ? 23.489 -44.884 -44.179 1.00 12.70 ? 347 GLN B C 1 ATOM 5543 O O . GLN B 1 363 ? 22.615 -45.745 -44.061 1.00 13.37 ? 347 GLN B O 1 ATOM 5544 C CB . GLN B 1 363 ? 23.926 -43.692 -42.047 1.00 12.02 ? 347 GLN B CB 1 ATOM 5545 C CG . GLN B 1 363 ? 24.744 -43.633 -40.761 1.00 12.37 ? 347 GLN B CG 1 ATOM 5546 C CD . GLN B 1 363 ? 24.778 -44.963 -40.018 1.00 15.41 ? 347 GLN B CD 1 ATOM 5547 O OE1 . GLN B 1 363 ? 23.792 -45.380 -39.415 1.00 15.26 ? 347 GLN B OE1 1 ATOM 5548 N NE2 . GLN B 1 363 ? 25.916 -45.631 -40.059 1.00 15.11 ? 347 GLN B NE2 1 ATOM 5549 N N . ASN B 1 364 ? 23.617 -44.106 -45.245 1.00 12.34 ? 348 ASN B N 1 ATOM 5550 C CA . ASN B 1 364 ? 22.617 -44.075 -46.309 1.00 13.37 ? 348 ASN B CA 1 ATOM 5551 C C . ASN B 1 364 ? 21.212 -43.967 -45.758 1.00 12.70 ? 348 ASN B C 1 ATOM 5552 O O . ASN B 1 364 ? 20.375 -44.820 -46.020 1.00 15.12 ? 348 ASN B O 1 ATOM 5553 C CB . ASN B 1 364 ? 22.727 -45.306 -47.189 1.00 13.36 ? 348 ASN B CB 1 ATOM 5554 C CG . ASN B 1 364 ? 24.061 -45.404 -47.862 1.00 11.40 ? 348 ASN B CG 1 ATOM 5555 O OD1 . ASN B 1 364 ? 24.416 -44.558 -48.653 1.00 15.96 ? 348 ASN B OD1 1 ATOM 5556 N ND2 . ASN B 1 364 ? 24.818 -46.420 -47.530 1.00 12.74 ? 348 ASN B ND2 1 ATOM 5557 N N . GLY B 1 365 ? 20.971 -42.900 -45.005 1.00 11.68 ? 349 GLY B N 1 ATOM 5558 C CA . GLY B 1 365 ? 19.677 -42.614 -44.431 1.00 10.12 ? 349 GLY B CA 1 ATOM 5559 C C . GLY B 1 365 ? 19.814 -41.499 -43.420 1.00 9.69 ? 349 GLY B C 1 ATOM 5560 O O . GLY B 1 365 ? 20.770 -40.751 -43.454 1.00 11.66 ? 349 GLY B O 1 ATOM 5561 N N . ARG B 1 366 ? 18.837 -41.379 -42.534 1.00 9.48 ? 350 ARG B N 1 ATOM 5562 C CA . ARG B 1 366 ? 18.918 -40.478 -41.378 1.00 9.79 ? 350 ARG B CA 1 ATOM 5563 C C . ARG B 1 366 ? 18.721 -39.018 -41.719 1.00 8.00 ? 350 ARG B C 1 ATOM 5564 O O . ARG B 1 366 ? 18.843 -38.172 -40.871 1.00 6.94 ? 350 ARG B O 1 ATOM 5565 C CB . ARG B 1 366 ? 20.235 -40.653 -40.626 1.00 8.81 ? 350 ARG B CB 1 ATOM 5566 C CG . ARG B 1 366 ? 20.428 -42.051 -40.079 1.00 7.15 ? 350 ARG B CG 1 ATOM 5567 C CD . ARG B 1 366 ? 21.704 -42.163 -39.304 1.00 6.97 ? 350 ARG B CD 1 ATOM 5568 N NE . ARG B 1 366 ? 21.804 -43.447 -38.631 1.00 5.56 ? 350 ARG B NE 1 ATOM 5569 C CZ . ARG B 1 366 ? 21.177 -43.754 -37.504 1.00 7.39 ? 350 ARG B CZ 1 ATOM 5570 N NH1 . ARG B 1 366 ? 20.398 -42.875 -36.909 1.00 9.54 ? 350 ARG B NH1 1 ATOM 5571 N NH2 . ARG B 1 366 ? 21.318 -44.951 -36.972 1.00 7.87 ? 350 ARG B NH2 1 ATOM 5572 N N . LEU B 1 367 ? 18.406 -38.721 -42.965 1.00 11.32 ? 351 LEU B N 1 ATOM 5573 C CA . LEU B 1 367 ? 18.020 -37.365 -43.321 1.00 10.83 ? 351 LEU B CA 1 ATOM 5574 C C . LEU B 1 367 ? 16.509 -37.239 -43.194 1.00 9.47 ? 351 LEU B C 1 ATOM 5575 O O . LEU B 1 367 ? 15.766 -37.964 -43.838 1.00 11.12 ? 351 LEU B O 1 ATOM 5576 C CB . LEU B 1 367 ? 18.473 -37.040 -44.743 1.00 9.34 ? 351 LEU B CB 1 ATOM 5577 C CG . LEU B 1 367 ? 18.014 -35.689 -45.295 1.00 10.77 ? 351 LEU B CG 1 ATOM 5578 C CD1 . LEU B 1 367 ? 18.605 -34.544 -44.496 1.00 9.12 ? 351 LEU B CD1 1 ATOM 5579 C CD2 . LEU B 1 367 ? 18.343 -35.559 -46.782 1.00 15.43 ? 351 LEU B CD2 1 ATOM 5580 N N . ILE B 1 368 ? 16.053 -36.331 -42.346 1.00 9.56 ? 352 ILE B N 1 ATOM 5581 C CA . ILE B 1 368 ? 14.620 -36.144 -42.138 1.00 12.89 ? 352 ILE B CA 1 ATOM 5582 C C . ILE B 1 368 ? 14.003 -35.112 -43.104 1.00 12.57 ? 352 ILE B C 1 ATOM 5583 O O . ILE B 1 368 ? 12.930 -35.328 -43.658 1.00 14.52 ? 352 ILE B O 1 ATOM 5584 C CB . ILE B 1 368 ? 14.326 -35.758 -40.679 1.00 11.83 ? 352 ILE B CB 1 ATOM 5585 C CG1 . ILE B 1 368 ? 14.718 -36.911 -39.747 1.00 10.44 ? 352 ILE B CG1 1 ATOM 5586 C CG2 . ILE B 1 368 ? 12.848 -35.417 -40.499 1.00 11.95 ? 352 ILE B CG2 1 ATOM 5587 C CD1 . ILE B 1 368 ? 14.763 -36.541 -38.307 1.00 7.35 ? 352 ILE B CD1 1 ATOM 5588 N N . THR B 1 369 ? 14.681 -33.998 -43.309 1.00 9.21 ? 353 THR B N 1 ATOM 5589 C CA . THR B 1 369 ? 14.248 -33.004 -44.276 1.00 12.07 ? 353 THR B CA 1 ATOM 5590 C C . THR B 1 369 ? 13.985 -33.582 -45.668 1.00 14.59 ? 353 THR B C 1 ATOM 5591 O O . THR B 1 369 ? 14.885 -34.115 -46.311 1.00 14.59 ? 353 THR B O 1 ATOM 5592 C CB . THR B 1 369 ? 15.319 -31.937 -44.446 1.00 11.71 ? 353 THR B CB 1 ATOM 5593 O OG1 . THR B 1 369 ? 15.567 -31.331 -43.188 1.00 9.29 ? 353 THR B OG1 1 ATOM 5594 C CG2 . THR B 1 369 ? 14.872 -30.889 -45.418 1.00 16.02 ? 353 THR B CG2 1 ATOM 5595 N N . ALA B 1 370 ? 12.761 -33.442 -46.157 1.00 19.36 ? 354 ALA B N 1 ATOM 5596 C CA . ALA B 1 370 ? 12.407 -34.041 -47.440 1.00 23.52 ? 354 ALA B CA 1 ATOM 5597 C C . ALA B 1 370 ? 13.013 -33.293 -48.630 1.00 22.25 ? 354 ALA B C 1 ATOM 5598 O O . ALA B 1 370 ? 13.606 -33.916 -49.505 1.00 29.42 ? 354 ALA B O 1 ATOM 5599 C CB . ALA B 1 370 ? 10.894 -34.152 -47.589 1.00 19.90 ? 354 ALA B CB 1 ATOM 5600 N N . ASN B 1 371 ? 12.876 -31.967 -48.658 1.00 20.20 ? 355 ASN B N 1 ATOM 5601 C CA . ASN B 1 371 ? 13.347 -31.175 -49.793 1.00 21.15 ? 355 ASN B CA 1 ATOM 5602 C C . ASN B 1 371 ? 14.654 -30.435 -49.485 1.00 18.30 ? 355 ASN B C 1 ATOM 5603 O O . ASN B 1 371 ? 14.658 -29.216 -49.316 1.00 21.10 ? 355 ASN B O 1 ATOM 5604 C CB . ASN B 1 371 ? 12.272 -30.161 -50.228 1.00 21.45 ? 355 ASN B CB 1 ATOM 5605 C CG . ASN B 1 371 ? 10.840 -30.695 -50.059 1.00 25.87 ? 355 ASN B CG 1 ATOM 5606 O OD1 . ASN B 1 371 ? 10.160 -30.378 -49.077 1.00 26.04 ? 355 ASN B OD1 1 ATOM 5607 N ND2 . ASN B 1 371 ? 10.384 -31.497 -51.017 1.00 19.74 ? 355 ASN B ND2 1 ATOM 5608 N N . PRO B 1 372 ? 15.774 -31.167 -49.418 1.00 18.46 ? 356 PRO B N 1 ATOM 5609 C CA . PRO B 1 372 ? 17.066 -30.534 -49.136 1.00 19.87 ? 356 PRO B CA 1 ATOM 5610 C C . PRO B 1 372 ? 17.617 -29.793 -50.347 1.00 15.03 ? 356 PRO B C 1 ATOM 5611 O O . PRO B 1 372 ? 18.556 -30.257 -50.955 1.00 16.05 ? 356 PRO B O 1 ATOM 5612 C CB . PRO B 1 372 ? 17.963 -31.723 -48.793 1.00 19.51 ? 356 PRO B CB 1 ATOM 5613 C CG . PRO B 1 372 ? 17.405 -32.830 -49.579 1.00 21.13 ? 356 PRO B CG 1 ATOM 5614 C CD . PRO B 1 372 ? 15.911 -32.623 -49.589 1.00 19.91 ? 356 PRO B CD 1 ATOM 5615 N N . ILE B 1 373 ? 17.040 -28.645 -50.666 1.00 14.92 ? 357 ILE B N 1 ATOM 5616 C CA . ILE B 1 373 ? 17.392 -27.913 -51.863 1.00 17.10 ? 357 ILE B CA 1 ATOM 5617 C C . ILE B 1 373 ? 17.718 -26.492 -51.470 1.00 16.18 ? 357 ILE B C 1 ATOM 5618 O O . ILE B 1 373 ? 17.041 -25.915 -50.634 1.00 16.16 ? 357 ILE B O 1 ATOM 5619 C CB . ILE B 1 373 ? 16.204 -27.910 -52.886 1.00 18.16 ? 357 ILE B CB 1 ATOM 5620 C CG1 . ILE B 1 373 ? 15.884 -29.333 -53.340 1.00 15.55 ? 357 ILE B CG1 1 ATOM 5621 C CG2 . ILE B 1 373 ? 16.485 -27.016 -54.108 1.00 15.85 ? 357 ILE B CG2 1 ATOM 5622 C CD1 . ILE B 1 373 ? 16.615 -29.769 -54.572 1.00 19.23 ? 357 ILE B CD1 1 ATOM 5623 N N . VAL B 1 374 ? 18.760 -25.932 -52.072 1.00 13.62 ? 358 VAL B N 1 ATOM 5624 C CA . VAL B 1 374 ? 19.008 -24.504 -51.986 1.00 16.80 ? 358 VAL B CA 1 ATOM 5625 C C . VAL B 1 374 ? 18.154 -23.854 -53.065 1.00 17.79 ? 358 VAL B C 1 ATOM 5626 O O . VAL B 1 374 ? 18.356 -24.122 -54.237 1.00 20.61 ? 358 VAL B O 1 ATOM 5627 C CB . VAL B 1 374 ? 20.507 -24.180 -52.240 1.00 18.54 ? 358 VAL B CB 1 ATOM 5628 C CG1 . VAL B 1 374 ? 20.791 -22.706 -52.052 1.00 12.62 ? 358 VAL B CG1 1 ATOM 5629 C CG2 . VAL B 1 374 ? 21.391 -25.002 -51.333 1.00 14.32 ? 358 VAL B CG2 1 ATOM 5630 N N . THR B 1 375 ? 17.183 -23.033 -52.676 1.00 19.32 ? 359 THR B N 1 ATOM 5631 C CA . THR B 1 375 ? 16.321 -22.361 -53.644 1.00 20.04 ? 359 THR B CA 1 ATOM 5632 C C . THR B 1 375 ? 16.828 -20.949 -53.876 1.00 21.99 ? 359 THR B C 1 ATOM 5633 O O . THR B 1 375 ? 16.541 -20.327 -54.902 1.00 29.45 ? 359 THR B O 1 ATOM 5634 C CB . THR B 1 375 ? 14.846 -22.290 -53.172 1.00 18.79 ? 359 THR B CB 1 ATOM 5635 O OG1 . THR B 1 375 ? 14.782 -21.634 -51.911 1.00 23.96 ? 359 THR B OG1 1 ATOM 5636 C CG2 . THR B 1 375 ? 14.246 -23.664 -53.017 1.00 15.52 ? 359 THR B CG2 1 ATOM 5637 N N . ASP B 1 376 ? 17.587 -20.450 -52.907 1.00 26.14 ? 360 ASP B N 1 ATOM 5638 C CA . ASP B 1 376 ? 18.143 -19.106 -52.955 1.00 24.19 ? 360 ASP B CA 1 ATOM 5639 C C . ASP B 1 376 ? 19.303 -19.010 -51.991 1.00 23.49 ? 360 ASP B C 1 ATOM 5640 O O . ASP B 1 376 ? 19.134 -19.181 -50.788 1.00 24.91 ? 360 ASP B O 1 ATOM 5641 C CB . ASP B 1 376 ? 17.093 -18.060 -52.568 1.00 28.10 ? 360 ASP B CB 1 ATOM 5642 C CG . ASP B 1 376 ? 17.666 -16.643 -52.511 1.00 31.68 ? 360 ASP B CG 1 ATOM 5643 O OD1 . ASP B 1 376 ? 18.554 -16.311 -53.314 1.00 36.04 ? 360 ASP B OD1 1 ATOM 5644 O OD2 . ASP B 1 376 ? 17.237 -15.842 -51.656 1.00 37.22 ? 360 ASP B OD2 1 ATOM 5645 N N . LYS B 1 377 ? 20.490 -18.738 -52.514 1.00 24.13 ? 361 LYS B N 1 ATOM 5646 C CA . LYS B 1 377 ? 21.609 -18.388 -51.654 1.00 28.17 ? 361 LYS B CA 1 ATOM 5647 C C . LYS B 1 377 ? 21.193 -17.119 -50.931 1.00 30.74 ? 361 LYS B C 1 ATOM 5648 O O . LYS B 1 377 ? 20.223 -16.470 -51.314 1.00 37.59 ? 361 LYS B O 1 ATOM 5649 C CB . LYS B 1 377 ? 22.867 -18.145 -52.473 1.00 30.44 ? 361 LYS B CB 1 ATOM 5650 C CG . LYS B 1 377 ? 23.270 -19.331 -53.318 1.00 30.17 ? 361 LYS B CG 1 ATOM 5651 C CD . LYS B 1 377 ? 23.977 -18.893 -54.578 1.00 34.88 ? 361 LYS B CD 1 ATOM 5652 C CE . LYS B 1 377 ? 25.367 -18.373 -54.295 1.00 36.51 ? 361 LYS B CE 1 ATOM 5653 N NZ . LYS B 1 377 ? 26.250 -19.461 -53.833 1.00 35.62 ? 361 LYS B NZ 1 ATOM 5654 N N . GLU B 1 378 ? 21.890 -16.770 -49.867 1.00 31.98 ? 362 GLU B N 1 ATOM 5655 C CA . GLU B 1 378 ? 21.468 -15.646 -49.043 1.00 31.28 ? 362 GLU B CA 1 ATOM 5656 C C . GLU B 1 378 ? 20.201 -15.990 -48.269 1.00 26.52 ? 362 GLU B C 1 ATOM 5657 O O . GLU B 1 378 ? 19.858 -15.317 -47.305 1.00 34.72 ? 362 GLU B O 1 ATOM 5658 C CB . GLU B 1 378 ? 21.270 -14.395 -49.889 1.00 34.66 ? 362 GLU B CB 1 ATOM 5659 N N . LYS B 1 379 ? 19.502 -17.038 -48.688 1.00 24.83 ? 363 LYS B N 1 ATOM 5660 C CA . LYS B 1 379 ? 18.502 -17.652 -47.837 1.00 26.87 ? 363 LYS B CA 1 ATOM 5661 C C . LYS B 1 379 ? 19.080 -18.955 -47.302 1.00 25.54 ? 363 LYS B C 1 ATOM 5662 O O . LYS B 1 379 ? 19.372 -19.867 -48.081 1.00 26.92 ? 363 LYS B O 1 ATOM 5663 C CB . LYS B 1 379 ? 17.235 -17.946 -48.622 1.00 28.09 ? 363 LYS B CB 1 ATOM 5664 C CG . LYS B 1 379 ? 15.969 -17.440 -47.966 1.00 30.18 ? 363 LYS B CG 1 ATOM 5665 C CD . LYS B 1 379 ? 14.757 -18.284 -48.353 1.00 35.46 ? 363 LYS B CD 1 ATOM 5666 C CE . LYS B 1 379 ? 14.471 -19.372 -47.314 1.00 35.19 ? 363 LYS B CE 1 ATOM 5667 N NZ . LYS B 1 379 ? 13.358 -20.293 -47.697 1.00 30.44 ? 363 LYS B NZ 1 ATOM 5668 N N . PRO B 1 380 ? 19.276 -19.043 -45.978 1.00 21.81 ? 364 PRO B N 1 ATOM 5669 C CA . PRO B 1 380 ? 19.814 -20.254 -45.345 1.00 21.79 ? 364 PRO B CA 1 ATOM 5670 C C . PRO B 1 380 ? 18.852 -21.455 -45.432 1.00 18.88 ? 364 PRO B C 1 ATOM 5671 O O . PRO B 1 380 ? 17.668 -21.279 -45.667 1.00 16.38 ? 364 PRO B O 1 ATOM 5672 C CB . PRO B 1 380 ? 20.005 -19.824 -43.888 1.00 20.76 ? 364 PRO B CB 1 ATOM 5673 C CG . PRO B 1 380 ? 19.064 -18.703 -43.702 1.00 25.51 ? 364 PRO B CG 1 ATOM 5674 C CD . PRO B 1 380 ? 19.040 -17.976 -44.995 1.00 26.00 ? 364 PRO B CD 1 ATOM 5675 N N . VAL B 1 381 ? 19.364 -22.664 -45.246 1.00 16.56 ? 365 VAL B N 1 ATOM 5676 C CA . VAL B 1 381 ? 18.526 -23.849 -45.332 1.00 18.67 ? 365 VAL B CA 1 ATOM 5677 C C . VAL B 1 381 ? 18.697 -24.683 -44.072 1.00 13.21 ? 365 VAL B C 1 ATOM 5678 O O . VAL B 1 381 ? 19.799 -24.960 -43.636 1.00 13.55 ? 365 VAL B O 1 ATOM 5679 C CB . VAL B 1 381 ? 18.829 -24.709 -46.599 1.00 19.34 ? 365 VAL B CB 1 ATOM 5680 C CG1 . VAL B 1 381 ? 17.809 -25.836 -46.757 1.00 14.75 ? 365 VAL B CG1 1 ATOM 5681 C CG2 . VAL B 1 381 ? 18.837 -23.852 -47.847 1.00 18.49 ? 365 VAL B CG2 1 ATOM 5682 N N . ASN B 1 382 ? 17.577 -25.053 -43.478 1.00 18.49 ? 366 ASN B N 1 ATOM 5683 C CA . ASN B 1 382 ? 17.570 -25.873 -42.289 1.00 15.17 ? 366 ASN B CA 1 ATOM 5684 C C . ASN B 1 382 ? 17.455 -27.339 -42.652 1.00 13.01 ? 366 ASN B C 1 ATOM 5685 O O . ASN B 1 382 ? 16.572 -27.734 -43.409 1.00 15.98 ? 366 ASN B O 1 ATOM 5686 C CB . ASN B 1 382 ? 16.415 -25.442 -41.392 1.00 19.20 ? 366 ASN B CB 1 ATOM 5687 C CG . ASN B 1 382 ? 16.405 -23.965 -41.168 1.00 15.85 ? 366 ASN B CG 1 ATOM 5688 O OD1 . ASN B 1 382 ? 17.187 -23.471 -40.379 1.00 16.06 ? 366 ASN B OD1 1 ATOM 5689 N ND2 . ASN B 1 382 ? 15.562 -23.241 -41.895 1.00 19.05 ? 366 ASN B ND2 1 ATOM 5690 N N . ILE B 1 383 ? 18.364 -28.136 -42.120 1.00 9.94 ? 367 ILE B N 1 ATOM 5691 C CA . ILE B 1 383 ? 18.381 -29.566 -42.363 1.00 12.43 ? 367 ILE B CA 1 ATOM 5692 C C . ILE B 1 383 ? 18.170 -30.277 -41.012 1.00 9.85 ? 367 ILE B C 1 ATOM 5693 O O . ILE B 1 383 ? 18.808 -29.944 -40.031 1.00 12.23 ? 367 ILE B O 1 ATOM 5694 C CB . ILE B 1 383 ? 19.722 -29.997 -43.034 1.00 9.61 ? 367 ILE B CB 1 ATOM 5695 C CG1 . ILE B 1 383 ? 19.875 -29.363 -44.405 1.00 11.56 ? 367 ILE B CG1 1 ATOM 5696 C CG2 . ILE B 1 383 ? 19.800 -31.489 -43.207 1.00 14.32 ? 367 ILE B CG2 1 ATOM 5697 C CD1 . ILE B 1 383 ? 21.221 -28.742 -44.627 1.00 15.67 ? 367 ILE B CD1 1 ATOM 5698 N N . GLU B 1 384 ? 17.228 -31.218 -40.959 1.00 11.85 ? 368 GLU B N 1 ATOM 5699 C CA . GLU B 1 384 ? 17.016 -32.038 -39.767 1.00 11.64 ? 368 GLU B CA 1 ATOM 5700 C C . GLU B 1 384 ? 17.495 -33.443 -40.087 1.00 8.28 ? 368 GLU B C 1 ATOM 5701 O O . GLU B 1 384 ? 17.290 -33.935 -41.180 1.00 9.41 ? 368 GLU B O 1 ATOM 5702 C CB . GLU B 1 384 ? 15.542 -32.050 -39.322 1.00 10.08 ? 368 GLU B CB 1 ATOM 5703 C CG . GLU B 1 384 ? 15.310 -32.778 -37.985 1.00 12.42 ? 368 GLU B CG 1 ATOM 5704 C CD . GLU B 1 384 ? 13.880 -32.680 -37.485 1.00 16.77 ? 368 GLU B CD 1 ATOM 5705 O OE1 . GLU B 1 384 ? 13.030 -32.250 -38.294 1.00 26.06 ? 368 GLU B OE1 1 ATOM 5706 O OE2 . GLU B 1 384 ? 13.611 -33.026 -36.304 1.00 15.50 ? 368 GLU B OE2 1 ATOM 5707 N N . ALA B 1 385 ? 18.176 -34.062 -39.136 1.00 7.06 ? 369 ALA B N 1 ATOM 5708 C CA . ALA B 1 385 ? 18.729 -35.378 -39.328 1.00 6.40 ? 369 ALA B CA 1 ATOM 5709 C C . ALA B 1 385 ? 18.565 -36.124 -38.033 1.00 5.02 ? 369 ALA B C 1 ATOM 5710 O O . ALA B 1 385 ? 18.299 -35.538 -36.995 1.00 6.97 ? 369 ALA B O 1 ATOM 5711 C CB . ALA B 1 385 ? 20.211 -35.299 -39.720 1.00 6.87 ? 369 ALA B CB 1 ATOM 5712 N N . GLU B 1 386 ? 18.701 -37.431 -38.110 1.00 5.55 ? 370 GLU B N 1 ATOM 5713 C CA . GLU B 1 386 ? 18.621 -38.271 -36.943 1.00 6.12 ? 370 GLU B CA 1 ATOM 5714 C C . GLU B 1 386 ? 19.901 -39.030 -36.764 1.00 6.65 ? 370 GLU B C 1 ATOM 5715 O O . GLU B 1 386 ? 20.059 -40.092 -37.316 1.00 8.80 ? 370 GLU B O 1 ATOM 5716 C CB . GLU B 1 386 ? 17.505 -39.253 -37.141 1.00 6.75 ? 370 GLU B CB 1 ATOM 5717 C CG . GLU B 1 386 ? 17.419 -40.239 -36.066 1.00 8.72 ? 370 GLU B CG 1 ATOM 5718 C CD . GLU B 1 386 ? 16.172 -41.007 -36.188 1.00 9.10 ? 370 GLU B CD 1 ATOM 5719 O OE1 . GLU B 1 386 ? 15.464 -40.772 -37.169 1.00 10.00 ? 370 GLU B OE1 1 ATOM 5720 O OE2 . GLU B 1 386 ? 15.896 -41.827 -35.315 1.00 13.00 ? 370 GLU B OE2 1 ATOM 5721 N N . PRO B 1 387 ? 20.826 -38.502 -35.967 1.00 8.68 ? 371 PRO B N 1 ATOM 5722 C CA . PRO B 1 387 ? 22.125 -39.159 -35.963 1.00 7.70 ? 371 PRO B CA 1 ATOM 5723 C C . PRO B 1 387 ? 22.080 -40.489 -35.225 1.00 8.50 ? 371 PRO B C 1 ATOM 5724 O O . PRO B 1 387 ? 21.172 -40.709 -34.435 1.00 9.86 ? 371 PRO B O 1 ATOM 5725 C CB . PRO B 1 387 ? 23.031 -38.140 -35.234 1.00 9.59 ? 371 PRO B CB 1 ATOM 5726 C CG . PRO B 1 387 ? 22.280 -36.869 -35.210 1.00 7.76 ? 371 PRO B CG 1 ATOM 5727 C CD . PRO B 1 387 ? 20.845 -37.267 -35.168 1.00 8.15 ? 371 PRO B CD 1 ATOM 5728 N N . PRO B 1 388 ? 23.032 -41.382 -35.516 1.00 7.62 ? 372 PRO B N 1 ATOM 5729 C CA . PRO B 1 388 ? 23.223 -42.610 -34.749 1.00 9.52 ? 372 PRO B CA 1 ATOM 5730 C C . PRO B 1 388 ? 23.582 -42.292 -33.321 1.00 8.16 ? 372 PRO B C 1 ATOM 5731 O O . PRO B 1 388 ? 24.117 -41.227 -33.075 1.00 7.30 ? 372 PRO B O 1 ATOM 5732 C CB . PRO B 1 388 ? 24.412 -43.276 -35.446 1.00 9.05 ? 372 PRO B CB 1 ATOM 5733 C CG . PRO B 1 388 ? 24.966 -42.264 -36.323 1.00 10.55 ? 372 PRO B CG 1 ATOM 5734 C CD . PRO B 1 388 ? 23.909 -41.348 -36.692 1.00 6.94 ? 372 PRO B CD 1 ATOM 5735 N N . PHE B 1 389 ? 23.296 -43.194 -32.391 1.00 11.67 ? 373 PHE B N 1 ATOM 5736 C CA . PHE B 1 389 ? 23.676 -42.958 -31.000 1.00 10.13 ? 373 PHE B CA 1 ATOM 5737 C C . PHE B 1 389 ? 25.177 -42.981 -30.912 1.00 11.41 ? 373 PHE B C 1 ATOM 5738 O O . PHE B 1 389 ? 25.821 -43.727 -31.625 1.00 13.00 ? 373 PHE B O 1 ATOM 5739 C CB . PHE B 1 389 ? 23.084 -44.002 -30.060 1.00 10.84 ? 373 PHE B CB 1 ATOM 5740 C CG . PHE B 1 389 ? 21.674 -43.732 -29.694 1.00 7.66 ? 373 PHE B CG 1 ATOM 5741 C CD1 . PHE B 1 389 ? 21.371 -42.772 -28.762 1.00 8.91 ? 373 PHE B CD1 1 ATOM 5742 C CD2 . PHE B 1 389 ? 20.653 -44.419 -30.292 1.00 11.60 ? 373 PHE B CD2 1 ATOM 5743 C CE1 . PHE B 1 389 ? 20.080 -42.500 -28.435 1.00 9.12 ? 373 PHE B CE1 1 ATOM 5744 C CE2 . PHE B 1 389 ? 19.350 -44.154 -29.963 1.00 9.78 ? 373 PHE B CE2 1 ATOM 5745 C CZ . PHE B 1 389 ? 19.060 -43.201 -29.033 1.00 8.89 ? 373 PHE B CZ 1 ATOM 5746 N N . GLY B 1 390 ? 25.726 -42.155 -30.037 1.00 11.68 ? 374 GLY B N 1 ATOM 5747 C CA . GLY B 1 390 ? 27.159 -42.101 -29.839 1.00 13.05 ? 374 GLY B CA 1 ATOM 5748 C C . GLY B 1 390 ? 27.798 -41.010 -30.656 1.00 10.30 ? 374 GLY B C 1 ATOM 5749 O O . GLY B 1 390 ? 27.169 -39.994 -30.920 1.00 10.60 ? 374 GLY B O 1 ATOM 5750 N N . GLU B 1 391 ? 29.054 -41.231 -31.039 1.00 9.24 ? 375 GLU B N 1 ATOM 5751 C CA . GLU B 1 391 ? 29.795 -40.304 -31.870 1.00 12.49 ? 375 GLU B CA 1 ATOM 5752 C C . GLU B 1 391 ? 29.440 -40.537 -33.341 1.00 13.79 ? 375 GLU B C 1 ATOM 5753 O O . GLU B 1 391 ? 29.327 -41.684 -33.791 1.00 14.16 ? 375 GLU B O 1 ATOM 5754 C CB . GLU B 1 391 ? 31.304 -40.486 -31.679 1.00 16.84 ? 375 GLU B CB 1 ATOM 5755 C CG . GLU B 1 391 ? 31.880 -40.002 -30.351 1.00 21.09 ? 375 GLU B CG 1 ATOM 5756 C CD . GLU B 1 391 ? 33.351 -40.421 -30.162 1.00 25.63 ? 375 GLU B CD 1 ATOM 5757 O OE1 . GLU B 1 391 ? 34.026 -39.878 -29.261 1.00 25.58 ? 375 GLU B OE1 1 ATOM 5758 O OE2 . GLU B 1 391 ? 33.822 -41.302 -30.915 1.00 27.26 ? 375 GLU B OE2 1 ATOM 5759 N N . SER B 1 392 ? 29.253 -39.446 -34.074 1.00 9.99 ? 376 SER B N 1 ATOM 5760 C CA . SER B 1 392 ? 28.918 -39.506 -35.482 1.00 10.07 ? 376 SER B CA 1 ATOM 5761 C C . SER B 1 392 ? 29.366 -38.228 -36.171 1.00 10.84 ? 376 SER B C 1 ATOM 5762 O O . SER B 1 392 ? 29.710 -37.252 -35.516 1.00 10.95 ? 376 SER B O 1 ATOM 5763 C CB . SER B 1 392 ? 27.407 -39.726 -35.667 1.00 13.01 ? 376 SER B CB 1 ATOM 5764 O OG . SER B 1 392 ? 26.640 -38.578 -35.350 1.00 11.71 ? 376 SER B OG 1 ATOM 5765 N N . TYR B 1 393 ? 29.376 -38.253 -37.498 1.00 12.06 ? 377 TYR B N 1 ATOM 5766 C CA . TYR B 1 393 ? 29.619 -37.065 -38.310 1.00 12.80 ? 377 TYR B CA 1 ATOM 5767 C C . TYR B 1 393 ? 28.460 -36.788 -39.279 1.00 12.43 ? 377 TYR B C 1 ATOM 5768 O O . TYR B 1 393 ? 27.752 -37.697 -39.708 1.00 11.58 ? 377 TYR B O 1 ATOM 5769 C CB . TYR B 1 393 ? 30.922 -37.197 -39.105 1.00 14.18 ? 377 TYR B CB 1 ATOM 5770 C CG . TYR B 1 393 ? 32.192 -36.969 -38.306 1.00 13.40 ? 377 TYR B CG 1 ATOM 5771 C CD1 . TYR B 1 393 ? 32.619 -35.683 -37.997 1.00 18.24 ? 377 TYR B CD1 1 ATOM 5772 C CD2 . TYR B 1 393 ? 32.970 -38.036 -37.877 1.00 15.30 ? 377 TYR B CD2 1 ATOM 5773 C CE1 . TYR B 1 393 ? 33.780 -35.468 -37.268 1.00 18.17 ? 377 TYR B CE1 1 ATOM 5774 C CE2 . TYR B 1 393 ? 34.128 -37.831 -37.146 1.00 15.08 ? 377 TYR B CE2 1 ATOM 5775 C CZ . TYR B 1 393 ? 34.531 -36.549 -36.854 1.00 17.16 ? 377 TYR B CZ 1 ATOM 5776 O OH . TYR B 1 393 ? 35.696 -36.344 -36.143 1.00 24.14 ? 377 TYR B OH 1 ATOM 5777 N N . ILE B 1 394 ? 28.281 -35.509 -39.593 1.00 14.20 ? 378 ILE B N 1 ATOM 5778 C CA . ILE B 1 394 ? 27.267 -35.031 -40.526 1.00 14.89 ? 378 ILE B CA 1 ATOM 5779 C C . ILE B 1 394 ? 28.012 -34.237 -41.561 1.00 12.26 ? 378 ILE B C 1 ATOM 5780 O O . ILE B 1 394 ? 28.663 -33.277 -41.217 1.00 12.61 ? 378 ILE B O 1 ATOM 5781 C CB . ILE B 1 394 ? 26.283 -34.075 -39.839 1.00 14.99 ? 378 ILE B CB 1 ATOM 5782 C CG1 . ILE B 1 394 ? 25.408 -34.827 -38.850 1.00 10.58 ? 378 ILE B CG1 1 ATOM 5783 C CG2 . ILE B 1 394 ? 25.415 -33.368 -40.857 1.00 13.70 ? 378 ILE B CG2 1 ATOM 5784 C CD1 . ILE B 1 394 ? 25.010 -33.962 -37.699 1.00 15.85 ? 378 ILE B CD1 1 ATOM 5785 N N . VAL B 1 395 ? 27.924 -34.637 -42.822 1.00 15.35 ? 379 VAL B N 1 ATOM 5786 C CA . VAL B 1 395 ? 28.715 -34.029 -43.872 1.00 15.51 ? 379 VAL B CA 1 ATOM 5787 C C . VAL B 1 395 ? 27.775 -33.304 -44.795 1.00 14.93 ? 379 VAL B C 1 ATOM 5788 O O . VAL B 1 395 ? 26.891 -33.903 -45.371 1.00 13.57 ? 379 VAL B O 1 ATOM 5789 C CB . VAL B 1 395 ? 29.482 -35.081 -44.680 1.00 16.19 ? 379 VAL B CB 1 ATOM 5790 C CG1 . VAL B 1 395 ? 30.382 -34.414 -45.699 1.00 16.36 ? 379 VAL B CG1 1 ATOM 5791 C CG2 . VAL B 1 395 ? 30.286 -35.972 -43.768 1.00 15.23 ? 379 VAL B CG2 1 ATOM 5792 N N . VAL B 1 396 ? 27.949 -32.001 -44.905 1.00 14.04 ? 380 VAL B N 1 ATOM 5793 C CA . VAL B 1 396 ? 27.087 -31.195 -45.740 1.00 16.68 ? 380 VAL B CA 1 ATOM 5794 C C . VAL B 1 396 ? 27.895 -30.727 -46.935 1.00 13.76 ? 380 VAL B C 1 ATOM 5795 O O . VAL B 1 396 ? 28.991 -30.210 -46.789 1.00 15.61 ? 380 VAL B O 1 ATOM 5796 C CB . VAL B 1 396 ? 26.519 -29.972 -44.974 1.00 11.96 ? 380 VAL B CB 1 ATOM 5797 C CG1 . VAL B 1 396 ? 25.758 -29.097 -45.906 1.00 17.77 ? 380 VAL B CG1 1 ATOM 5798 C CG2 . VAL B 1 396 ? 25.637 -30.410 -43.832 1.00 16.76 ? 380 VAL B CG2 1 ATOM 5799 N N . GLY B 1 397 ? 27.360 -30.943 -48.125 1.00 16.05 ? 381 GLY B N 1 ATOM 5800 C CA . GLY B 1 397 ? 28.000 -30.471 -49.330 1.00 19.26 ? 381 GLY B CA 1 ATOM 5801 C C . GLY B 1 397 ? 28.996 -31.500 -49.791 1.00 20.06 ? 381 GLY B C 1 ATOM 5802 O O . GLY B 1 397 ? 29.242 -32.474 -49.079 1.00 21.65 ? 381 GLY B O 1 ATOM 5803 N N . ALA B 1 398 ? 29.571 -31.289 -50.971 1.00 22.04 ? 382 ALA B N 1 ATOM 5804 C CA . ALA B 1 398 ? 30.424 -32.303 -51.571 1.00 25.05 ? 382 ALA B CA 1 ATOM 5805 C C . ALA B 1 398 ? 31.847 -31.806 -51.823 1.00 27.42 ? 382 ALA B C 1 ATOM 5806 O O . ALA B 1 398 ? 32.164 -30.627 -51.624 1.00 28.22 ? 382 ALA B O 1 ATOM 5807 C CB . ALA B 1 398 ? 29.804 -32.802 -52.850 1.00 25.32 ? 382 ALA B CB 1 ATOM 5808 N N . GLY B 1 399 ? 32.699 -32.728 -52.260 1.00 31.20 ? 383 GLY B N 1 ATOM 5809 C CA . GLY B 1 399 ? 34.086 -32.414 -52.544 1.00 33.93 ? 383 GLY B CA 1 ATOM 5810 C C . GLY B 1 399 ? 34.840 -32.191 -51.258 1.00 33.80 ? 383 GLY B C 1 ATOM 5811 O O . GLY B 1 399 ? 34.239 -31.886 -50.239 1.00 37.01 ? 383 GLY B O 1 ATOM 5812 N N . GLU B 1 400 ? 36.156 -32.319 -51.295 1.00 28.24 ? 384 GLU B N 1 ATOM 5813 C CA . GLU B 1 400 ? 36.921 -32.285 -50.065 1.00 33.61 ? 384 GLU B CA 1 ATOM 5814 C C . GLU B 1 400 ? 36.655 -30.982 -49.289 1.00 33.91 ? 384 GLU B C 1 ATOM 5815 O O . GLU B 1 400 ? 37.084 -30.840 -48.144 1.00 35.04 ? 384 GLU B O 1 ATOM 5816 C CB . GLU B 1 400 ? 38.417 -32.528 -50.350 1.00 39.24 ? 384 GLU B CB 1 ATOM 5817 C CG . GLU B 1 400 ? 38.775 -33.997 -50.758 1.00 33.28 ? 384 GLU B CG 1 ATOM 5818 C CD . GLU B 1 400 ? 39.088 -34.898 -49.567 1.00 29.63 ? 384 GLU B CD 1 ATOM 5819 O OE1 . GLU B 1 400 ? 39.222 -34.354 -48.446 1.00 36.73 ? 384 GLU B OE1 1 ATOM 5820 O OE2 . GLU B 1 400 ? 39.178 -36.146 -49.745 1.00 18.37 ? 384 GLU B OE2 1 ATOM 5821 N N . LYS B 1 401 ? 35.921 -30.050 -49.898 1.00 29.74 ? 385 LYS B N 1 ATOM 5822 C CA . LYS B 1 401 ? 35.469 -28.843 -49.186 1.00 30.97 ? 385 LYS B CA 1 ATOM 5823 C C . LYS B 1 401 ? 34.173 -29.079 -48.372 1.00 33.11 ? 385 LYS B C 1 ATOM 5824 O O . LYS B 1 401 ? 33.608 -28.143 -47.783 1.00 27.56 ? 385 LYS B O 1 ATOM 5825 C CB . LYS B 1 401 ? 35.273 -27.690 -50.174 1.00 30.29 ? 385 LYS B CB 1 ATOM 5826 N N . ALA B 1 402 ? 33.708 -30.329 -48.347 1.00 29.46 ? 386 ALA B N 1 ATOM 5827 C CA . ALA B 1 402 ? 32.476 -30.684 -47.664 1.00 24.73 ? 386 ALA B CA 1 ATOM 5828 C C . ALA B 1 402 ? 32.578 -30.307 -46.205 1.00 23.63 ? 386 ALA B C 1 ATOM 5829 O O . ALA B 1 402 ? 33.611 -30.500 -45.580 1.00 30.95 ? 386 ALA B O 1 ATOM 5830 C CB . ALA B 1 402 ? 32.202 -32.166 -47.800 1.00 22.02 ? 386 ALA B CB 1 ATOM 5831 N N . LEU B 1 403 ? 31.499 -29.765 -45.666 1.00 21.96 ? 387 LEU B N 1 ATOM 5832 C CA . LEU B 1 403 ? 31.470 -29.343 -44.279 1.00 19.02 ? 387 LEU B CA 1 ATOM 5833 C C . LEU B 1 403 ? 31.213 -30.558 -43.401 1.00 13.12 ? 387 LEU B C 1 ATOM 5834 O O . LEU B 1 403 ? 30.253 -31.265 -43.620 1.00 14.51 ? 387 LEU B O 1 ATOM 5835 C CB . LEU B 1 403 ? 30.395 -28.275 -44.135 1.00 17.49 ? 387 LEU B CB 1 ATOM 5836 C CG . LEU B 1 403 ? 29.926 -27.802 -42.771 1.00 17.94 ? 387 LEU B CG 1 ATOM 5837 C CD1 . LEU B 1 403 ? 31.082 -27.274 -41.967 1.00 22.05 ? 387 LEU B CD1 1 ATOM 5838 C CD2 . LEU B 1 403 ? 28.839 -26.725 -42.956 1.00 18.59 ? 387 LEU B CD2 1 ATOM 5839 N N . LYS B 1 404 ? 32.093 -30.824 -42.439 1.00 12.00 ? 388 LYS B N 1 ATOM 5840 C CA . LYS B 1 404 ? 32.018 -32.066 -41.667 1.00 15.86 ? 388 LYS B CA 1 ATOM 5841 C C . LYS B 1 404 ? 31.842 -31.797 -40.180 1.00 13.38 ? 388 LYS B C 1 ATOM 5842 O O . LYS B 1 404 ? 32.773 -31.402 -39.494 1.00 14.61 ? 388 LYS B O 1 ATOM 5843 C CB . LYS B 1 404 ? 33.259 -32.925 -41.915 1.00 19.24 ? 388 LYS B CB 1 ATOM 5844 C CG . LYS B 1 404 ? 33.189 -34.340 -41.334 1.00 21.26 ? 388 LYS B CG 1 ATOM 5845 C CD . LYS B 1 404 ? 34.481 -35.135 -41.636 1.00 27.81 ? 388 LYS B CD 1 ATOM 5846 C CE . LYS B 1 404 ? 34.297 -36.645 -41.478 1.00 22.95 ? 388 LYS B CE 1 ATOM 5847 N NZ . LYS B 1 404 ? 35.514 -37.309 -40.949 1.00 21.23 ? 388 LYS B NZ 1 ATOM 5848 N N . LEU B 1 405 ? 30.639 -32.056 -39.694 1.00 11.02 ? 389 LEU B N 1 ATOM 5849 C CA . LEU B 1 405 ? 30.233 -31.675 -38.360 1.00 9.13 ? 389 LEU B CA 1 ATOM 5850 C C . LEU B 1 405 ? 30.170 -32.892 -37.476 1.00 10.13 ? 389 LEU B C 1 ATOM 5851 O O . LEU B 1 405 ? 29.575 -33.888 -37.847 1.00 11.70 ? 389 LEU B O 1 ATOM 5852 C CB . LEU B 1 405 ? 28.839 -31.058 -38.420 1.00 9.34 ? 389 LEU B CB 1 ATOM 5853 C CG . LEU B 1 405 ? 28.657 -29.981 -39.476 1.00 10.96 ? 389 LEU B CG 1 ATOM 5854 C CD1 . LEU B 1 405 ? 27.185 -29.680 -39.702 1.00 12.06 ? 389 LEU B CD1 1 ATOM 5855 C CD2 . LEU B 1 405 ? 29.437 -28.745 -39.044 1.00 9.94 ? 389 LEU B CD2 1 ATOM 5856 N N . SER B 1 406 ? 30.768 -32.802 -36.297 1.00 10.82 ? 390 SER B N 1 ATOM 5857 C CA . SER B 1 406 ? 30.679 -33.882 -35.322 1.00 11.38 ? 390 SER B CA 1 ATOM 5858 C C . SER B 1 406 ? 29.444 -33.736 -34.421 1.00 8.81 ? 390 SER B C 1 ATOM 5859 O O . SER B 1 406 ? 28.882 -32.661 -34.256 1.00 10.80 ? 390 SER B O 1 ATOM 5860 C CB . SER B 1 406 ? 31.985 -34.016 -34.488 1.00 11.98 ? 390 SER B CB 1 ATOM 5861 O OG . SER B 1 406 ? 32.384 -32.799 -33.875 1.00 12.89 ? 390 SER B OG 1 ATOM 5862 N N . TRP B 1 407 ? 29.022 -34.857 -33.865 1.00 9.49 ? 391 TRP B N 1 ATOM 5863 C CA . TRP B 1 407 ? 27.912 -34.887 -32.942 1.00 11.19 ? 391 TRP B CA 1 ATOM 5864 C C . TRP B 1 407 ? 28.030 -36.072 -31.978 1.00 10.32 ? 391 TRP B C 1 ATOM 5865 O O . TRP B 1 407 ? 28.412 -37.162 -32.362 1.00 10.81 ? 391 TRP B O 1 ATOM 5866 C CB . TRP B 1 407 ? 26.591 -34.951 -33.704 1.00 8.25 ? 391 TRP B CB 1 ATOM 5867 C CG . TRP B 1 407 ? 25.490 -34.747 -32.788 1.00 11.28 ? 391 TRP B CG 1 ATOM 5868 C CD1 . TRP B 1 407 ? 24.692 -35.698 -32.242 1.00 12.62 ? 391 TRP B CD1 1 ATOM 5869 C CD2 . TRP B 1 407 ? 25.080 -33.502 -32.227 1.00 11.03 ? 391 TRP B CD2 1 ATOM 5870 N NE1 . TRP B 1 407 ? 23.801 -35.124 -31.374 1.00 10.84 ? 391 TRP B NE1 1 ATOM 5871 C CE2 . TRP B 1 407 ? 24.015 -33.773 -31.355 1.00 11.48 ? 391 TRP B CE2 1 ATOM 5872 C CE3 . TRP B 1 407 ? 25.509 -32.181 -32.383 1.00 12.78 ? 391 TRP B CE3 1 ATOM 5873 C CZ2 . TRP B 1 407 ? 23.360 -32.772 -30.648 1.00 15.70 ? 391 TRP B CZ2 1 ATOM 5874 C CZ3 . TRP B 1 407 ? 24.865 -31.191 -31.672 1.00 13.76 ? 391 TRP B CZ3 1 ATOM 5875 C CH2 . TRP B 1 407 ? 23.797 -31.492 -30.819 1.00 15.94 ? 391 TRP B CH2 1 ATOM 5876 N N . PHE B 1 408 ? 27.729 -35.852 -30.708 1.00 9.51 ? 392 PHE B N 1 ATOM 5877 C CA . PHE B 1 408 ? 27.609 -36.962 -29.778 1.00 11.06 ? 392 PHE B CA 1 ATOM 5878 C C . PHE B 1 408 ? 26.168 -37.049 -29.282 1.00 10.18 ? 392 PHE B C 1 ATOM 5879 O O . PHE B 1 408 ? 25.617 -36.073 -28.758 1.00 10.66 ? 392 PHE B O 1 ATOM 5880 C CB . PHE B 1 408 ? 28.593 -36.835 -28.605 1.00 11.89 ? 392 PHE B CB 1 ATOM 5881 C CG . PHE B 1 408 ? 28.432 -37.918 -27.583 1.00 12.77 ? 392 PHE B CG 1 ATOM 5882 C CD1 . PHE B 1 408 ? 28.888 -39.195 -27.827 1.00 12.92 ? 392 PHE B CD1 1 ATOM 5883 C CD2 . PHE B 1 408 ? 27.789 -37.664 -26.389 1.00 14.25 ? 392 PHE B CD2 1 ATOM 5884 C CE1 . PHE B 1 408 ? 28.710 -40.193 -26.898 1.00 11.57 ? 392 PHE B CE1 1 ATOM 5885 C CE2 . PHE B 1 408 ? 27.605 -38.655 -25.475 1.00 16.58 ? 392 PHE B CE2 1 ATOM 5886 C CZ . PHE B 1 408 ? 28.061 -39.925 -25.735 1.00 16.94 ? 392 PHE B CZ 1 ATOM 5887 N N . LYS B 1 409 ? 25.553 -38.207 -29.489 1.00 9.02 ? 393 LYS B N 1 ATOM 5888 C CA . LYS B 1 409 ? 24.147 -38.423 -29.119 1.00 11.80 ? 393 LYS B CA 1 ATOM 5889 C C . LYS B 1 409 ? 24.039 -39.369 -27.923 1.00 12.47 ? 393 LYS B C 1 ATOM 5890 O O . LYS B 1 409 ? 24.397 -40.533 -28.009 1.00 12.27 ? 393 LYS B O 1 ATOM 5891 C CB . LYS B 1 409 ? 23.372 -38.948 -30.336 1.00 11.49 ? 393 LYS B CB 1 ATOM 5892 C CG . LYS B 1 409 ? 21.970 -39.456 -30.101 1.00 8.63 ? 393 LYS B CG 1 ATOM 5893 C CD . LYS B 1 409 ? 21.277 -39.547 -31.457 1.00 9.82 ? 393 LYS B CD 1 ATOM 5894 C CE . LYS B 1 409 ? 20.029 -40.377 -31.444 1.00 9.70 ? 393 LYS B CE 1 ATOM 5895 N NZ . LYS B 1 409 ? 19.282 -40.153 -32.699 1.00 9.11 ? 393 LYS B NZ 1 ATOM 5896 N N . LYS B 1 410 ? 23.588 -38.862 -26.785 1.00 13.59 ? 394 LYS B N 1 ATOM 5897 C CA . LYS B 1 410 ? 23.502 -39.718 -25.603 1.00 14.90 ? 394 LYS B CA 1 ATOM 5898 C C . LYS B 1 410 ? 22.231 -40.560 -25.678 1.00 11.37 ? 394 LYS B C 1 ATOM 5899 O O . LYS B 1 410 ? 21.341 -40.290 -26.487 1.00 11.95 ? 394 LYS B O 1 ATOM 5900 C CB . LYS B 1 410 ? 23.621 -38.920 -24.290 1.00 12.64 ? 394 LYS B CB 1 ATOM 5901 C CG . LYS B 1 410 ? 22.505 -37.924 -24.020 1.00 23.26 ? 394 LYS B CG 1 ATOM 5902 C CD . LYS B 1 410 ? 22.709 -37.130 -22.719 1.00 31.84 ? 394 LYS B CD 1 ATOM 5903 C CE . LYS B 1 410 ? 23.271 -35.727 -23.001 1.00 38.21 ? 394 LYS B CE 1 ATOM 5904 N NZ . LYS B 1 410 ? 22.703 -34.648 -22.123 1.00 42.39 ? 394 LYS B NZ 1 ATOM 5905 N N . GLY B 1 411 ? 22.182 -41.617 -24.879 1.00 12.93 ? 395 GLY B N 1 ATOM 5906 C CA . GLY B 1 411 ? 21.029 -42.502 -24.829 1.00 12.47 ? 395 GLY B CA 1 ATOM 5907 C C . GLY B 1 411 ? 19.784 -41.789 -24.343 1.00 10.59 ? 395 GLY B C 1 ATOM 5908 O O . GLY B 1 411 ? 19.871 -40.761 -23.681 1.00 11.38 ? 395 GLY B O 1 ATOM 5909 N N . SER B 1 412 ? 18.617 -42.342 -24.650 1.00 9.75 ? 396 SER B N 1 ATOM 5910 C CA . SER B 1 412 ? 17.370 -41.661 -24.341 1.00 9.28 ? 396 SER B CA 1 ATOM 5911 C C . SER B 1 412 ? 17.111 -41.615 -22.848 1.00 6.99 ? 396 SER B C 1 ATOM 5912 O O . SER B 1 412 ? 17.515 -42.507 -22.134 1.00 8.24 ? 396 SER B O 1 ATOM 5913 C CB . SER B 1 412 ? 16.211 -42.345 -25.054 1.00 8.95 ? 396 SER B CB 1 ATOM 5914 O OG . SER B 1 412 ? 16.514 -42.564 -26.422 1.00 9.18 ? 396 SER B OG 1 ATOM 5915 N N . SER B 1 413 ? 16.439 -40.572 -22.373 1.00 8.42 ? 397 SER B N 1 ATOM 5916 C CA . SER B 1 413 ? 16.130 -40.461 -20.958 1.00 8.06 ? 397 SER B CA 1 ATOM 5917 C C . SER B 1 413 ? 14.731 -39.920 -20.803 1.00 6.55 ? 397 SER B C 1 ATOM 5918 O O . SER B 1 413 ? 14.335 -39.144 -21.621 1.00 6.15 ? 397 SER B O 1 ATOM 5919 C CB . SER B 1 413 ? 17.124 -39.521 -20.295 1.00 7.03 ? 397 SER B CB 1 ATOM 5920 O OG . SER B 1 413 ? 16.715 -39.238 -18.978 1.00 8.69 ? 397 SER B OG 1 ATOM 5921 N N . ILE B 1 414 ? 13.995 -40.297 -19.753 1.00 6.99 ? 398 ILE B N 1 ATOM 5922 C CA . ILE B 1 414 ? 12.679 -39.701 -19.511 1.00 9.89 ? 398 ILE B CA 1 ATOM 5923 C C . ILE B 1 414 ? 12.745 -38.345 -18.808 1.00 8.74 ? 398 ILE B C 1 ATOM 5924 O O . ILE B 1 414 ? 11.759 -37.632 -18.727 1.00 8.41 ? 398 ILE B O 1 ATOM 5925 C CB . ILE B 1 414 ? 11.715 -40.630 -18.741 1.00 7.28 ? 398 ILE B CB 1 ATOM 5926 C CG1 . ILE B 1 414 ? 12.175 -40.866 -17.302 1.00 8.72 ? 398 ILE B CG1 1 ATOM 5927 C CG2 . ILE B 1 414 ? 11.550 -41.909 -19.492 1.00 13.39 ? 398 ILE B CG2 1 ATOM 5928 C CD1 . ILE B 1 414 ? 11.154 -41.625 -16.441 1.00 7.95 ? 398 ILE B CD1 1 ATOM 5929 N N . GLY B 1 415 ? 13.916 -37.989 -18.310 1.00 11.61 ? 399 GLY B N 1 ATOM 5930 C CA . GLY B 1 415 ? 14.134 -36.665 -17.773 1.00 9.73 ? 399 GLY B CA 1 ATOM 5931 C C . GLY B 1 415 ? 15.003 -36.682 -16.530 1.00 10.02 ? 399 GLY B C 1 ATOM 5932 O O . GLY B 1 415 ? 15.466 -37.727 -16.093 1.00 8.07 ? 399 GLY B O 1 ATOM 5933 N N . LYS B 1 416 ? 15.207 -35.484 -15.989 1.00 13.64 ? 400 LYS B N 1 ATOM 5934 C CA . LYS B 1 416 ? 15.929 -35.257 -14.746 1.00 14.95 ? 400 LYS B CA 1 ATOM 5935 C C . LYS B 1 416 ? 15.041 -35.555 -13.552 1.00 13.56 ? 400 LYS B C 1 ATOM 5936 O O . LYS B 1 416 ? 13.873 -35.204 -13.549 1.00 11.82 ? 400 LYS B O 1 ATOM 5937 C CB . LYS B 1 416 ? 16.347 -33.779 -14.649 1.00 14.95 ? 400 LYS B CB 1 ATOM 5938 C CG . LYS B 1 416 ? 17.711 -33.396 -15.202 1.00 20.59 ? 400 LYS B CG 1 ATOM 5939 C CD . LYS B 1 416 ? 18.057 -31.903 -14.892 1.00 26.42 ? 400 LYS B CD 1 ATOM 5940 C CE . LYS B 1 416 ? 19.079 -31.721 -13.738 1.00 28.79 ? 400 LYS B CE 1 ATOM 5941 N NZ . LYS B 1 416 ? 19.733 -30.363 -13.694 1.00 23.70 ? 400 LYS B NZ 1 ATOM 5942 N N . MET B 1 417 ? 15.609 -36.141 -12.506 1.00 14.47 ? 401 MET B N 1 ATOM 5943 C CA . MET B 1 417 ? 14.877 -36.304 -11.254 1.00 18.35 ? 401 MET B CA 1 ATOM 5944 C C . MET B 1 417 ? 14.599 -34.981 -10.557 1.00 16.38 ? 401 MET B C 1 ATOM 5945 O O . MET B 1 417 ? 15.464 -34.144 -10.416 1.00 14.76 ? 401 MET B O 1 ATOM 5946 C CB . MET B 1 417 ? 15.655 -37.167 -10.276 1.00 21.38 ? 401 MET B CB 1 ATOM 5947 C CG . MET B 1 417 ? 14.843 -37.558 -9.067 1.00 21.42 ? 401 MET B CG 1 ATOM 5948 S SD . MET B 1 417 ? 13.771 -38.932 -9.434 1.00 26.58 ? 401 MET B SD 1 ATOM 5949 C CE . MET B 1 417 ? 15.001 -40.212 -9.621 1.00 22.25 ? 401 MET B CE 1 ATOM 5950 N N . PHE B 1 418 ? 13.365 -34.823 -10.119 1.00 16.13 ? 402 PHE B N 1 ATOM 5951 C CA . PHE B 1 418 ? 12.956 -33.710 -9.287 1.00 22.57 ? 402 PHE B CA 1 ATOM 5952 C C . PHE B 1 418 ? 13.479 -33.884 -7.857 1.00 22.22 ? 402 PHE B C 1 ATOM 5953 O O . PHE B 1 418 ? 13.400 -34.973 -7.292 1.00 20.53 ? 402 PHE B O 1 ATOM 5954 C CB . PHE B 1 418 ? 11.428 -33.636 -9.300 1.00 18.97 ? 402 PHE B CB 1 ATOM 5955 C CG . PHE B 1 418 ? 10.870 -32.646 -8.354 1.00 19.53 ? 402 PHE B CG 1 ATOM 5956 C CD1 . PHE B 1 418 ? 10.690 -31.339 -8.732 1.00 19.19 ? 402 PHE B CD1 1 ATOM 5957 C CD2 . PHE B 1 418 ? 10.531 -33.019 -7.078 1.00 22.36 ? 402 PHE B CD2 1 ATOM 5958 C CE1 . PHE B 1 418 ? 10.167 -30.424 -7.849 1.00 18.66 ? 402 PHE B CE1 1 ATOM 5959 C CE2 . PHE B 1 418 ? 10.018 -32.107 -6.196 1.00 19.90 ? 402 PHE B CE2 1 ATOM 5960 C CZ . PHE B 1 418 ? 9.839 -30.810 -6.582 1.00 17.68 ? 402 PHE B CZ 1 ATOM 5961 N N . GLU B 1 419 ? 14.023 -32.803 -7.296 1.00 25.66 ? 403 GLU B N 1 ATOM 5962 C CA . GLU B 1 419 ? 14.497 -32.763 -5.908 1.00 26.61 ? 403 GLU B CA 1 ATOM 5963 C C . GLU B 1 419 ? 13.748 -31.689 -5.086 1.00 25.69 ? 403 GLU B C 1 ATOM 5964 O O . GLU B 1 419 ? 13.962 -30.494 -5.275 1.00 29.87 ? 403 GLU B O 1 ATOM 5965 C CB . GLU B 1 419 ? 16.008 -32.447 -5.858 1.00 27.09 ? 403 GLU B CB 1 ATOM 5966 C CG . GLU B 1 419 ? 16.902 -33.212 -6.846 1.00 30.48 ? 403 GLU B CG 1 ATOM 5967 C CD . GLU B 1 419 ? 16.889 -34.727 -6.625 1.00 34.13 ? 403 GLU B CD 1 ATOM 5968 O OE1 . GLU B 1 419 ? 17.794 -35.432 -7.142 1.00 35.19 ? 403 GLU B OE1 1 ATOM 5969 O OE2 . GLU B 1 419 ? 15.962 -35.215 -5.943 1.00 35.43 ? 403 GLU B OE2 1 ATOM 5970 N N . ALA B 1 420 ? 12.873 -32.108 -4.176 1.00 30.29 ? 404 ALA B N 1 ATOM 5971 C CA . ALA B 1 420 ? 12.124 -31.167 -3.338 1.00 27.27 ? 404 ALA B CA 1 ATOM 5972 C C . ALA B 1 420 ? 13.009 -30.589 -2.249 1.00 31.70 ? 404 ALA B C 1 ATOM 5973 O O . ALA B 1 420 ? 14.133 -30.179 -2.517 1.00 35.20 ? 404 ALA B O 1 ATOM 5974 C CB . ALA B 1 420 ? 10.903 -31.846 -2.714 1.00 24.83 ? 404 ALA B CB 1 HETATM 5975 C C1 . NAG C 2 . ? 20.603 -2.558 -8.961 1.00 40.50 ? 501 NAG A C1 1 HETATM 5976 C C2 . NAG C 2 . ? 21.389 -1.456 -8.247 1.00 37.91 ? 501 NAG A C2 1 HETATM 5977 C C3 . NAG C 2 . ? 20.403 -0.493 -7.595 1.00 41.92 ? 501 NAG A C3 1 HETATM 5978 C C4 . NAG C 2 . ? 19.131 -0.569 -8.447 1.00 51.46 ? 501 NAG A C4 1 HETATM 5979 C C5 . NAG C 2 . ? 18.467 -1.930 -8.198 1.00 44.92 ? 501 NAG A C5 1 HETATM 5980 C C6 . NAG C 2 . ? 17.438 -2.291 -9.260 1.00 46.95 ? 501 NAG A C6 1 HETATM 5981 C C7 . NAG C 2 . ? 23.499 -2.371 -7.638 1.00 36.21 ? 501 NAG A C7 1 HETATM 5982 C C8 . NAG C 2 . ? 24.597 -2.139 -6.642 1.00 32.00 ? 501 NAG A C8 1 HETATM 5983 N N2 . NAG C 2 . ? 22.281 -2.020 -7.254 1.00 37.27 ? 501 NAG A N2 1 HETATM 5984 O O3 . NAG C 2 . ? 20.923 0.826 -7.463 1.00 33.35 ? 501 NAG A O3 1 HETATM 5985 O O4 . NAG C 2 . ? 18.244 0.495 -8.163 1.00 55.44 ? 501 NAG A O4 1 HETATM 5986 O O5 . NAG C 2 . ? 19.461 -2.933 -8.220 1.00 40.19 ? 501 NAG A O5 1 HETATM 5987 O O6 . NAG C 2 . ? 16.585 -3.290 -8.743 1.00 44.81 ? 501 NAG A O6 1 HETATM 5988 O O7 . NAG C 2 . ? 23.725 -2.855 -8.752 1.00 34.96 ? 501 NAG A O7 1 HETATM 5989 CD CD . CD D 3 . ? 27.141 -25.236 -27.861 1.00 43.67 ? 502 CD A CD 1 HETATM 5990 CD CD . CD E 3 . ? 28.653 -29.634 53.448 1.00 52.09 ? 503 CD A CD 1 HETATM 5991 CL CL . CL F 4 . ? 26.412 -20.501 -32.709 1.00 12.96 ? 504 CL A CL 1 HETATM 5992 C C1 . NAG G 2 . ? -10.183 -18.279 9.291 1.00 54.97 ? 501 NAG B C1 1 HETATM 5993 C C2 . NAG G 2 . ? -11.679 -18.011 9.376 1.00 57.93 ? 501 NAG B C2 1 HETATM 5994 C C3 . NAG G 2 . ? -12.032 -16.523 9.411 1.00 57.79 ? 501 NAG B C3 1 HETATM 5995 C C4 . NAG G 2 . ? -11.055 -15.665 10.205 1.00 55.77 ? 501 NAG B C4 1 HETATM 5996 C C5 . NAG G 2 . ? -9.614 -16.103 9.978 1.00 55.84 ? 501 NAG B C5 1 HETATM 5997 C C6 . NAG G 2 . ? -8.612 -15.308 10.822 1.00 59.09 ? 501 NAG B C6 1 HETATM 5998 C C7 . NAG G 2 . ? -11.825 -18.565 7.004 1.00 62.19 ? 501 NAG B C7 1 HETATM 5999 C C8 . NAG G 2 . ? -12.438 -17.527 6.109 1.00 65.25 ? 501 NAG B C8 1 HETATM 6000 N N2 . NAG G 2 . ? -12.321 -18.647 8.240 1.00 57.87 ? 501 NAG B N2 1 HETATM 6001 O O3 . NAG G 2 . ? -13.300 -16.382 10.004 1.00 55.52 ? 501 NAG B O3 1 HETATM 6002 O O4 . NAG G 2 . ? -11.193 -14.326 9.787 1.00 48.92 ? 501 NAG B O4 1 HETATM 6003 O O5 . NAG G 2 . ? -9.492 -17.485 10.233 1.00 56.15 ? 501 NAG B O5 1 HETATM 6004 O O6 . NAG G 2 . ? -8.764 -15.522 12.212 1.00 53.90 ? 501 NAG B O6 1 HETATM 6005 O O7 . NAG G 2 . ? -10.925 -19.284 6.574 1.00 59.25 ? 501 NAG B O7 1 HETATM 6006 CD CD . CD H 3 . ? 9.534 -36.982 -52.375 1.00 54.43 ? 502 CD B CD 1 HETATM 6007 CD CD . CD I 3 . ? 11.082 -29.316 -38.149 1.00 53.15 ? 503 CD B CD 1 HETATM 6008 O O . HOH J 5 . ? 30.552 -11.958 25.798 1.00 9.18 ? 601 HOH A O 1 HETATM 6009 O O . HOH J 5 . ? 30.347 -19.121 26.000 1.00 12.01 ? 602 HOH A O 1 HETATM 6010 O O . HOH J 5 . ? 13.625 -20.259 57.375 1.00 13.86 ? 603 HOH A O 1 HETATM 6011 O O . HOH J 5 . ? 23.822 -28.497 18.630 1.00 8.10 ? 604 HOH A O 1 HETATM 6012 O O . HOH J 5 . ? 31.017 -9.507 18.989 1.00 7.17 ? 605 HOH A O 1 HETATM 6013 O O . HOH J 5 . ? 32.847 -28.232 -24.903 1.00 9.93 ? 606 HOH A O 1 HETATM 6014 O O . HOH J 5 . ? 22.348 -24.588 61.423 1.00 19.34 ? 607 HOH A O 1 HETATM 6015 O O . HOH J 5 . ? 30.036 -17.751 -14.840 1.00 12.23 ? 608 HOH A O 1 HETATM 6016 O O . HOH J 5 . ? 33.827 -8.810 45.110 1.00 13.74 ? 609 HOH A O 1 HETATM 6017 O O . HOH J 5 . ? 23.359 -30.946 17.778 1.00 12.97 ? 610 HOH A O 1 HETATM 6018 O O . HOH J 5 . ? 30.864 -6.305 45.931 1.00 10.76 ? 611 HOH A O 1 HETATM 6019 O O . HOH J 5 . ? 29.457 -33.372 24.898 1.00 12.54 ? 612 HOH A O 1 HETATM 6020 O O . HOH J 5 . ? 29.051 -23.545 -23.157 1.00 16.03 ? 613 HOH A O 1 HETATM 6021 O O . HOH J 5 . ? 28.934 -37.294 17.794 1.00 12.67 ? 614 HOH A O 1 HETATM 6022 O O . HOH J 5 . ? 19.416 -21.419 47.088 1.00 14.06 ? 615 HOH A O 1 HETATM 6023 O O . HOH J 5 . ? 22.324 -27.656 34.009 1.00 22.81 ? 616 HOH A O 1 HETATM 6024 O O . HOH J 5 . ? 21.623 -19.756 -17.020 1.00 13.08 ? 617 HOH A O 1 HETATM 6025 O O . HOH J 5 . ? 22.878 -12.960 -16.747 1.00 12.61 ? 618 HOH A O 1 HETATM 6026 O O . HOH J 5 . ? 21.615 -13.570 26.900 1.00 12.22 ? 619 HOH A O 1 HETATM 6027 O O . HOH J 5 . ? 35.147 -17.966 -10.792 1.00 16.67 ? 620 HOH A O 1 HETATM 6028 O O . HOH J 5 . ? 32.216 -34.070 36.214 1.00 8.47 ? 621 HOH A O 1 HETATM 6029 O O . HOH J 5 . ? 35.880 -9.242 27.267 1.00 12.21 ? 622 HOH A O 1 HETATM 6030 O O . HOH J 5 . ? 30.409 -30.196 51.618 1.00 14.78 ? 623 HOH A O 1 HETATM 6031 O O . HOH J 5 . ? 31.559 -15.528 41.585 1.00 12.35 ? 624 HOH A O 1 HETATM 6032 O O . HOH J 5 . ? 18.498 -5.247 48.641 1.00 21.86 ? 625 HOH A O 1 HETATM 6033 O O . HOH J 5 . ? 24.523 -25.873 52.021 1.00 19.02 ? 626 HOH A O 1 HETATM 6034 O O . HOH J 5 . ? 17.481 -18.351 37.408 1.00 14.68 ? 627 HOH A O 1 HETATM 6035 O O . HOH J 5 . ? 27.594 -20.767 -30.041 1.00 14.90 ? 628 HOH A O 1 HETATM 6036 O O . HOH J 5 . ? 20.050 -30.959 9.391 1.00 17.64 ? 629 HOH A O 1 HETATM 6037 O O . HOH J 5 . ? 24.871 -36.969 19.255 1.00 23.28 ? 630 HOH A O 1 HETATM 6038 O O . HOH J 5 . ? 27.549 -34.184 26.907 1.00 21.79 ? 631 HOH A O 1 HETATM 6039 O O . HOH J 5 . ? 25.253 -25.688 0.699 1.00 16.97 ? 632 HOH A O 1 HETATM 6040 O O . HOH J 5 . ? 35.357 -14.767 30.212 1.00 10.32 ? 633 HOH A O 1 HETATM 6041 O O . HOH J 5 . ? 36.800 -12.949 28.729 1.00 15.26 ? 634 HOH A O 1 HETATM 6042 O O . HOH J 5 . ? 16.478 -35.558 61.243 1.00 21.67 ? 635 HOH A O 1 HETATM 6043 O O . HOH J 5 . ? 33.158 -0.112 17.215 1.00 17.87 ? 636 HOH A O 1 HETATM 6044 O O . HOH J 5 . ? 36.434 -15.854 -18.207 1.00 23.90 ? 637 HOH A O 1 HETATM 6045 O O . HOH J 5 . ? 16.630 -14.386 -4.458 1.00 15.70 ? 638 HOH A O 1 HETATM 6046 O O . HOH J 5 . ? 23.179 -28.499 24.877 1.00 13.54 ? 639 HOH A O 1 HETATM 6047 O O . HOH J 5 . ? 33.554 -27.734 20.572 1.00 14.28 ? 640 HOH A O 1 HETATM 6048 O O . HOH J 5 . ? 30.087 -38.215 33.718 1.00 15.94 ? 641 HOH A O 1 HETATM 6049 O O . HOH J 5 . ? 26.406 -10.464 -21.448 1.00 16.54 ? 642 HOH A O 1 HETATM 6050 O O . HOH J 5 . ? 29.352 -8.543 43.638 1.00 13.10 ? 643 HOH A O 1 HETATM 6051 O O . HOH J 5 . ? 22.014 -28.902 29.609 1.00 17.46 ? 644 HOH A O 1 HETATM 6052 O O . HOH J 5 . ? 25.729 -21.366 38.026 1.00 12.94 ? 645 HOH A O 1 HETATM 6053 O O . HOH J 5 . ? 35.342 -25.972 54.514 1.00 9.40 ? 646 HOH A O 1 HETATM 6054 O O . HOH J 5 . ? 30.414 -20.760 11.820 1.00 11.56 ? 647 HOH A O 1 HETATM 6055 O O . HOH J 5 . ? 31.588 -4.684 -17.914 1.00 14.10 ? 648 HOH A O 1 HETATM 6056 O O . HOH J 5 . ? 20.706 -12.114 38.650 1.00 16.75 ? 649 HOH A O 1 HETATM 6057 O O . HOH J 5 . ? 31.837 -21.744 32.662 1.00 14.68 ? 650 HOH A O 1 HETATM 6058 O O . HOH J 5 . ? 15.044 -44.512 53.069 1.00 17.53 ? 651 HOH A O 1 HETATM 6059 O O . HOH J 5 . ? 14.753 -28.598 58.620 1.00 36.49 ? 652 HOH A O 1 HETATM 6060 O O . HOH J 5 . ? 12.590 -37.565 38.306 1.00 22.24 ? 653 HOH A O 1 HETATM 6061 O O . HOH J 5 . ? 15.388 -20.084 44.711 1.00 24.50 ? 654 HOH A O 1 HETATM 6062 O O . HOH J 5 . ? 15.008 -25.631 50.733 1.00 19.75 ? 655 HOH A O 1 HETATM 6063 O O . HOH J 5 . ? 28.122 -50.834 30.678 1.00 17.21 ? 656 HOH A O 1 HETATM 6064 O O . HOH J 5 . ? 18.043 -6.749 36.076 1.00 26.75 ? 657 HOH A O 1 HETATM 6065 O O . HOH J 5 . ? 17.119 -4.985 46.021 1.00 26.94 ? 658 HOH A O 1 HETATM 6066 O O . HOH J 5 . ? 19.699 -14.582 -11.961 1.00 14.69 ? 659 HOH A O 1 HETATM 6067 O O . HOH J 5 . ? 15.584 -26.129 5.726 1.00 21.38 ? 660 HOH A O 1 HETATM 6068 O O . HOH J 5 . ? 27.767 -23.390 -20.809 1.00 16.04 ? 661 HOH A O 1 HETATM 6069 O O . HOH J 5 . ? 18.913 -19.377 1.289 1.00 17.65 ? 662 HOH A O 1 HETATM 6070 O O . HOH J 5 . ? 31.967 -40.510 22.862 1.00 15.80 ? 663 HOH A O 1 HETATM 6071 O O . HOH J 5 . ? 33.417 -30.207 14.596 1.00 14.54 ? 664 HOH A O 1 HETATM 6072 O O . HOH J 5 . ? 11.973 -45.925 48.569 1.00 20.27 ? 665 HOH A O 1 HETATM 6073 O O . HOH J 5 . ? 29.728 -20.691 -14.535 1.00 18.57 ? 666 HOH A O 1 HETATM 6074 O O . HOH J 5 . ? 35.377 -14.239 -32.641 1.00 7.96 ? 667 HOH A O 1 HETATM 6075 O O . HOH J 5 . ? 31.979 -46.600 33.249 1.00 24.71 ? 668 HOH A O 1 HETATM 6076 O O . HOH J 5 . ? 36.143 -8.446 46.470 1.00 22.32 ? 669 HOH A O 1 HETATM 6077 O O . HOH J 5 . ? 32.755 -15.288 -39.454 1.00 17.30 ? 670 HOH A O 1 HETATM 6078 O O . HOH J 5 . ? 26.060 -25.656 54.549 1.00 12.64 ? 671 HOH A O 1 HETATM 6079 O O . HOH J 5 . ? 28.224 -9.720 35.300 1.00 14.36 ? 672 HOH A O 1 HETATM 6080 O O . HOH J 5 . ? 7.467 -45.508 54.132 1.00 24.61 ? 673 HOH A O 1 HETATM 6081 O O . HOH J 5 . ? 21.991 -32.402 19.842 1.00 14.59 ? 674 HOH A O 1 HETATM 6082 O O . HOH J 5 . ? 36.831 -5.829 -12.727 1.00 29.18 ? 675 HOH A O 1 HETATM 6083 O O . HOH J 5 . ? 20.928 -32.711 11.265 1.00 16.68 ? 676 HOH A O 1 HETATM 6084 O O . HOH J 5 . ? 26.419 -20.681 -25.848 1.00 17.33 ? 677 HOH A O 1 HETATM 6085 O O . HOH J 5 . ? 35.280 -20.651 -36.980 1.00 23.75 ? 678 HOH A O 1 HETATM 6086 O O . HOH J 5 . ? 36.181 -12.613 -10.302 1.00 35.92 ? 679 HOH A O 1 HETATM 6087 O O . HOH J 5 . ? 12.516 -18.258 34.514 1.00 38.05 ? 680 HOH A O 1 HETATM 6088 O O . HOH J 5 . ? 19.942 -9.387 -3.150 1.00 16.49 ? 681 HOH A O 1 HETATM 6089 O O . HOH J 5 . ? 16.277 -21.125 30.527 1.00 23.15 ? 682 HOH A O 1 HETATM 6090 O O . HOH J 5 . ? 31.505 -17.802 -2.164 1.00 23.28 ? 683 HOH A O 1 HETATM 6091 O O . HOH J 5 . ? 31.445 -15.635 -24.339 1.00 46.14 ? 684 HOH A O 1 HETATM 6092 O O . HOH J 5 . ? 24.090 -44.582 38.716 1.00 12.70 ? 685 HOH A O 1 HETATM 6093 O O . HOH J 5 . ? 35.845 -12.703 -35.559 1.00 10.68 ? 686 HOH A O 1 HETATM 6094 O O . HOH J 5 . ? 28.502 -8.436 19.910 1.00 11.78 ? 687 HOH A O 1 HETATM 6095 O O . HOH J 5 . ? 31.558 -40.451 35.111 1.00 18.21 ? 688 HOH A O 1 HETATM 6096 O O . HOH J 5 . ? 37.581 -21.793 -36.095 1.00 28.17 ? 689 HOH A O 1 HETATM 6097 O O . HOH J 5 . ? 32.675 -9.813 -5.712 1.00 22.35 ? 690 HOH A O 1 HETATM 6098 O O . HOH J 5 . ? 38.786 -22.393 54.410 0.33 5.73 ? 691 HOH A O 1 HETATM 6099 O O . HOH J 5 . ? 36.859 -10.370 -34.769 1.00 15.29 ? 692 HOH A O 1 HETATM 6100 O O . HOH J 5 . ? 38.825 -14.562 -38.072 1.00 27.43 ? 693 HOH A O 1 HETATM 6101 O O . HOH J 5 . ? 23.342 -37.081 31.576 1.00 17.79 ? 694 HOH A O 1 HETATM 6102 O O . HOH J 5 . ? 18.200 -8.863 37.565 1.00 36.21 ? 695 HOH A O 1 HETATM 6103 O O . HOH J 5 . ? 36.260 -14.276 -37.793 1.00 19.10 ? 696 HOH A O 1 HETATM 6104 O O . HOH J 5 . ? 27.178 -23.002 -8.336 1.00 14.59 ? 697 HOH A O 1 HETATM 6105 O O . HOH J 5 . ? 20.004 -17.727 -18.737 1.00 25.49 ? 698 HOH A O 1 HETATM 6106 O O . HOH J 5 . ? 30.580 -50.204 31.798 1.00 28.01 ? 699 HOH A O 1 HETATM 6107 O O . HOH J 5 . ? 13.113 -37.027 62.729 1.00 33.87 ? 700 HOH A O 1 HETATM 6108 O O . HOH J 5 . ? 20.922 -52.359 45.881 1.00 31.83 ? 701 HOH A O 1 HETATM 6109 O O . HOH J 5 . ? 16.720 -25.123 -0.725 1.00 36.05 ? 702 HOH A O 1 HETATM 6110 O O . HOH J 5 . ? 22.291 -54.854 46.081 1.00 30.50 ? 703 HOH A O 1 HETATM 6111 O O . HOH J 5 . ? 27.297 -23.515 37.307 1.00 27.03 ? 704 HOH A O 1 HETATM 6112 O O . HOH J 5 . ? 31.346 -28.251 45.919 1.00 22.03 ? 705 HOH A O 1 HETATM 6113 O O . HOH J 5 . ? 19.966 -26.678 -13.638 1.00 24.08 ? 706 HOH A O 1 HETATM 6114 O O . HOH J 5 . ? 31.891 -24.270 -20.609 1.00 23.72 ? 707 HOH A O 1 HETATM 6115 O O . HOH J 5 . ? 25.401 -26.271 3.640 1.00 27.04 ? 708 HOH A O 1 HETATM 6116 O O . HOH J 5 . ? 7.557 -34.364 59.556 1.00 33.09 ? 709 HOH A O 1 HETATM 6117 O O . HOH J 5 . ? 25.867 -26.930 -26.236 1.00 25.13 ? 710 HOH A O 1 HETATM 6118 O O . HOH J 5 . ? 18.024 -32.016 7.532 1.00 20.31 ? 711 HOH A O 1 HETATM 6119 O O . HOH J 5 . ? 35.495 -13.771 1.806 1.00 26.71 ? 712 HOH A O 1 HETATM 6120 O O . HOH J 5 . ? 15.558 -31.261 8.051 1.00 19.31 ? 713 HOH A O 1 HETATM 6121 O O . HOH J 5 . ? 33.899 -11.687 8.656 1.00 15.09 ? 714 HOH A O 1 HETATM 6122 O O . HOH J 5 . ? 10.099 -28.910 44.943 1.00 38.45 ? 715 HOH A O 1 HETATM 6123 O O . HOH J 5 . ? 30.832 -54.921 33.592 1.00 65.09 ? 716 HOH A O 1 HETATM 6124 O O . HOH J 5 . ? 34.451 -20.953 33.209 1.00 25.07 ? 717 HOH A O 1 HETATM 6125 O O . HOH J 5 . ? 22.721 -31.878 53.830 1.00 26.46 ? 718 HOH A O 1 HETATM 6126 O O . HOH J 5 . ? 18.912 -19.465 39.694 1.00 11.11 ? 719 HOH A O 1 HETATM 6127 O O . HOH J 5 . ? 28.293 -44.036 23.621 1.00 19.04 ? 720 HOH A O 1 HETATM 6128 O O . HOH J 5 . ? 27.581 -1.493 -10.055 1.00 27.99 ? 721 HOH A O 1 HETATM 6129 O O . HOH J 5 . ? 21.512 -24.992 -20.136 1.00 47.47 ? 722 HOH A O 1 HETATM 6130 O O . HOH J 5 . ? 39.251 -15.579 -18.034 1.00 33.90 ? 723 HOH A O 1 HETATM 6131 O O . HOH J 5 . ? 34.663 -9.507 7.091 1.00 39.26 ? 724 HOH A O 1 HETATM 6132 O O . HOH J 5 . ? 25.155 -34.904 50.945 1.00 34.52 ? 725 HOH A O 1 HETATM 6133 O O . HOH J 5 . ? 33.178 -23.572 42.830 1.00 21.94 ? 726 HOH A O 1 HETATM 6134 O O . HOH J 5 . ? 38.677 -9.111 27.735 1.00 19.83 ? 727 HOH A O 1 HETATM 6135 O O . HOH J 5 . ? 22.074 -26.333 -15.686 1.00 28.29 ? 728 HOH A O 1 HETATM 6136 O O . HOH J 5 . ? 21.671 -55.152 40.883 1.00 62.34 ? 729 HOH A O 1 HETATM 6137 O O . HOH J 5 . ? 17.828 -18.616 -23.447 1.00 41.16 ? 730 HOH A O 1 HETATM 6138 O O . HOH J 5 . ? 31.885 -18.007 -6.123 1.00 41.71 ? 731 HOH A O 1 HETATM 6139 O O . HOH J 5 . ? 26.670 -24.065 -24.527 1.00 17.45 ? 732 HOH A O 1 HETATM 6140 O O . HOH J 5 . ? 16.317 1.787 -6.434 1.00 68.10 ? 733 HOH A O 1 HETATM 6141 O O . HOH J 5 . ? 19.152 -12.218 21.853 1.00 37.83 ? 734 HOH A O 1 HETATM 6142 O O . HOH J 5 . ? 30.382 -21.273 9.141 1.00 17.02 ? 735 HOH A O 1 HETATM 6143 O O . HOH J 5 . ? 30.477 -4.848 -22.575 1.00 25.22 ? 736 HOH A O 1 HETATM 6144 O O . HOH J 5 . ? 14.997 -9.569 29.821 1.00 26.87 ? 737 HOH A O 1 HETATM 6145 O O . HOH J 5 . ? 36.125 -27.433 21.349 1.00 15.11 ? 738 HOH A O 1 HETATM 6146 O O . HOH J 5 . ? 41.111 -7.246 27.437 1.00 23.88 ? 739 HOH A O 1 HETATM 6147 O O . HOH J 5 . ? 27.437 -6.105 -19.709 1.00 25.56 ? 740 HOH A O 1 HETATM 6148 O O . HOH J 5 . ? 27.459 -33.370 66.529 1.00 41.44 ? 741 HOH A O 1 HETATM 6149 O O . HOH J 5 . ? 39.235 -12.139 67.813 1.00 21.12 ? 742 HOH A O 1 HETATM 6150 O O . HOH J 5 . ? 32.404 -11.242 0.490 1.00 22.14 ? 743 HOH A O 1 HETATM 6151 O O . HOH J 5 . ? 35.238 -2.122 11.207 1.00 27.41 ? 744 HOH A O 1 HETATM 6152 O O . HOH J 5 . ? 16.684 -42.047 64.915 1.00 38.13 ? 745 HOH A O 1 HETATM 6153 O O . HOH J 5 . ? 23.609 -28.494 -25.178 1.00 48.62 ? 746 HOH A O 1 HETATM 6154 O O . HOH J 5 . ? 26.751 -6.526 -22.401 1.00 29.43 ? 747 HOH A O 1 HETATM 6155 O O . HOH J 5 . ? 17.832 -8.385 34.148 1.00 36.67 ? 748 HOH A O 1 HETATM 6156 O O . HOH J 5 . ? 39.247 -7.433 -14.014 1.00 28.51 ? 749 HOH A O 1 HETATM 6157 O O . HOH J 5 . ? 9.480 -19.905 12.227 1.00 36.10 ? 750 HOH A O 1 HETATM 6158 O O . HOH J 5 . ? 38.656 -6.133 -20.628 1.00 49.13 ? 751 HOH A O 1 HETATM 6159 O O . HOH J 5 . ? 16.722 -7.579 28.466 1.00 31.05 ? 752 HOH A O 1 HETATM 6160 O O . HOH J 5 . ? 9.983 -14.125 59.237 1.00 11.61 ? 753 HOH A O 1 HETATM 6161 O O . HOH J 5 . ? 26.233 -28.915 20.265 1.00 8.89 ? 754 HOH A O 1 HETATM 6162 O O . HOH J 5 . ? 24.714 -44.929 33.927 1.00 11.72 ? 755 HOH A O 1 HETATM 6163 O O . HOH J 5 . ? 25.872 -25.356 35.904 1.00 20.09 ? 756 HOH A O 1 HETATM 6164 O O . HOH J 5 . ? 38.990 -11.453 29.529 1.00 11.01 ? 757 HOH A O 1 HETATM 6165 O O . HOH J 5 . ? 23.846 -8.772 -17.808 1.00 11.03 ? 758 HOH A O 1 HETATM 6166 O O . HOH J 5 . ? 38.207 -14.828 1.382 1.00 28.21 ? 759 HOH A O 1 HETATM 6167 O O . HOH J 5 . ? 17.093 -13.817 21.341 1.00 43.41 ? 760 HOH A O 1 HETATM 6168 O O . HOH J 5 . ? 14.816 -6.280 49.606 1.00 32.53 ? 761 HOH A O 1 HETATM 6169 O O . HOH J 5 . ? 36.341 -26.445 27.669 1.00 21.96 ? 762 HOH A O 1 HETATM 6170 O O . HOH J 5 . ? 12.037 -14.675 4.353 1.00 29.86 ? 763 HOH A O 1 HETATM 6171 O O . HOH J 5 . ? 37.442 -17.859 5.374 1.00 35.88 ? 764 HOH A O 1 HETATM 6172 O O . HOH J 5 . ? 16.230 -13.694 19.121 1.00 31.47 ? 765 HOH A O 1 HETATM 6173 O O . HOH J 5 . ? 34.327 -9.452 -3.482 1.00 37.12 ? 766 HOH A O 1 HETATM 6174 O O . HOH J 5 . ? 36.699 -16.664 3.689 1.00 24.76 ? 767 HOH A O 1 HETATM 6175 O O . HOH J 5 . ? 14.845 -15.486 -22.689 1.00 39.90 ? 768 HOH A O 1 HETATM 6176 O O . HOH J 5 . ? 22.954 -9.298 20.143 1.00 33.14 ? 769 HOH A O 1 HETATM 6177 O O . HOH J 5 . ? 17.088 -16.516 -6.415 1.00 28.00 ? 770 HOH A O 1 HETATM 6178 O O . HOH J 5 . ? 23.161 -25.920 -13.310 1.00 22.81 ? 771 HOH A O 1 HETATM 6179 O O . HOH J 5 . ? 28.730 -50.239 49.459 1.00 22.69 ? 772 HOH A O 1 HETATM 6180 O O . HOH J 5 . ? 34.542 -10.875 30.996 1.00 8.61 ? 773 HOH A O 1 HETATM 6181 O O . HOH J 5 . ? 15.016 -20.585 -13.211 1.00 17.70 ? 774 HOH A O 1 HETATM 6182 O O . HOH J 5 . ? 32.342 -43.388 34.261 1.00 8.78 ? 775 HOH A O 1 HETATM 6183 O O . HOH J 5 . ? 21.537 -12.170 23.704 1.00 15.07 ? 776 HOH A O 1 HETATM 6184 O O . HOH J 5 . ? 28.788 -31.641 55.269 1.00 22.07 ? 777 HOH A O 1 HETATM 6185 O O . HOH J 5 . ? 23.378 -9.091 3.911 1.00 15.37 ? 778 HOH A O 1 HETATM 6186 O O . HOH J 5 . ? 34.456 -16.620 1.123 1.00 36.03 ? 779 HOH A O 1 HETATM 6187 O O . HOH J 5 . ? 7.066 -32.979 57.093 1.00 20.26 ? 780 HOH A O 1 HETATM 6188 O O . HOH J 5 . ? 31.192 -3.371 -15.298 1.00 14.51 ? 781 HOH A O 1 HETATM 6189 O O . HOH J 5 . ? 30.151 -26.797 50.871 1.00 17.47 ? 782 HOH A O 1 HETATM 6190 O O . HOH J 5 . ? 26.338 -9.040 1.309 1.00 21.09 ? 783 HOH A O 1 HETATM 6191 O O . HOH J 5 . ? 26.655 -35.634 24.738 1.00 14.83 ? 784 HOH A O 1 HETATM 6192 O O . HOH J 5 . ? 33.305 -15.357 -0.975 1.00 29.92 ? 785 HOH A O 1 HETATM 6193 O O . HOH J 5 . ? 34.220 -18.596 37.410 1.00 29.20 ? 786 HOH A O 1 HETATM 6194 O O . HOH J 5 . ? 28.550 -45.311 27.314 1.00 22.10 ? 787 HOH A O 1 HETATM 6195 O O . HOH J 5 . ? 31.624 2.419 16.073 1.00 33.48 ? 788 HOH A O 1 HETATM 6196 O O . HOH J 5 . ? 11.590 -17.910 4.296 1.00 21.29 ? 789 HOH A O 1 HETATM 6197 O O . HOH J 5 . ? 17.995 -22.477 61.021 1.00 18.91 ? 790 HOH A O 1 HETATM 6198 O O . HOH J 5 . ? 35.746 -17.807 72.779 1.00 26.10 ? 791 HOH A O 1 HETATM 6199 O O . HOH J 5 . ? 28.898 -3.800 55.709 1.00 60.15 ? 792 HOH A O 1 HETATM 6200 O O . HOH J 5 . ? 29.248 -7.684 -22.388 1.00 43.18 ? 793 HOH A O 1 HETATM 6201 O O . HOH J 5 . ? 19.430 -24.377 61.346 1.00 19.17 ? 794 HOH A O 1 HETATM 6202 O O . HOH J 5 . ? 25.350 -9.323 21.557 1.00 36.56 ? 795 HOH A O 1 HETATM 6203 O O . HOH J 5 . ? 23.426 -0.748 0.160 1.00 29.66 ? 796 HOH A O 1 HETATM 6204 O O . HOH J 5 . ? 19.960 -5.816 44.793 1.00 27.46 ? 797 HOH A O 1 HETATM 6205 O O . HOH J 5 . ? 32.378 -16.439 -41.678 1.00 62.38 ? 798 HOH A O 1 HETATM 6206 O O . HOH J 5 . ? 27.885 -2.610 54.108 1.00 21.75 ? 799 HOH A O 1 HETATM 6207 O O . HOH J 5 . ? 35.548 -20.008 6.102 1.00 37.04 ? 800 HOH A O 1 HETATM 6208 O O . HOH J 5 . ? 32.760 -9.704 -27.985 1.00 14.63 ? 801 HOH A O 1 HETATM 6209 O O . HOH J 5 . ? 36.653 -19.117 36.645 1.00 56.46 ? 802 HOH A O 1 HETATM 6210 O O . HOH J 5 . ? 23.113 -29.425 36.312 1.00 18.33 ? 803 HOH A O 1 HETATM 6211 O O . HOH J 5 . ? 27.287 -44.100 46.050 1.00 17.22 ? 804 HOH A O 1 HETATM 6212 O O . HOH J 5 . ? 24.622 -30.569 21.763 1.00 15.73 ? 805 HOH A O 1 HETATM 6213 O O . HOH J 5 . ? 15.723 -16.598 22.153 1.00 32.64 ? 806 HOH A O 1 HETATM 6214 O O . HOH J 5 . ? 23.020 -10.144 23.290 1.00 19.44 ? 807 HOH A O 1 HETATM 6215 O O . HOH J 5 . ? 16.179 -43.277 62.698 1.00 32.15 ? 808 HOH A O 1 HETATM 6216 O O . HOH J 5 . ? 20.590 -12.196 -28.101 1.00 37.82 ? 809 HOH A O 1 HETATM 6217 O O . HOH J 5 . ? 21.003 -2.076 0.449 1.00 61.67 ? 810 HOH A O 1 HETATM 6218 O O . HOH J 5 . ? 8.752 -46.778 45.955 1.00 31.22 ? 811 HOH A O 1 HETATM 6219 O O . HOH J 5 . ? 28.630 -9.990 1.337 1.00 19.08 ? 812 HOH A O 1 HETATM 6220 O O . HOH J 5 . ? 17.884 -55.609 40.678 1.00 41.91 ? 813 HOH A O 1 HETATM 6221 O O . HOH J 5 . ? 36.718 -12.480 5.901 1.00 29.70 ? 814 HOH A O 1 HETATM 6222 O O . HOH J 5 . ? 10.440 -29.584 24.631 1.00 75.97 ? 815 HOH A O 1 HETATM 6223 O O . HOH J 5 . ? 37.203 -20.358 9.587 1.00 23.00 ? 816 HOH A O 1 HETATM 6224 O O . HOH J 5 . ? 13.758 -16.336 64.034 1.00 32.13 ? 817 HOH A O 1 HETATM 6225 O O . HOH J 5 . ? 18.481 -17.026 -25.353 1.00 68.80 ? 818 HOH A O 1 HETATM 6226 O O . HOH J 5 . ? 11.639 -28.932 21.390 1.00 38.47 ? 819 HOH A O 1 HETATM 6227 O O . HOH J 5 . ? 17.368 -55.813 43.897 1.00 58.33 ? 820 HOH A O 1 HETATM 6228 O O . HOH J 5 . ? 22.789 -13.620 -29.121 1.00 51.64 ? 821 HOH A O 1 HETATM 6229 O O . HOH J 5 . ? 12.713 -7.837 48.905 1.00 64.52 ? 822 HOH A O 1 HETATM 6230 O O . HOH J 5 . ? 29.431 -28.481 12.447 1.00 18.98 ? 823 HOH A O 1 HETATM 6231 O O . HOH J 5 . ? 27.257 -29.839 11.688 1.00 27.45 ? 824 HOH A O 1 HETATM 6232 O O . HOH J 5 . ? 10.845 -50.936 40.906 1.00 17.46 ? 825 HOH A O 1 HETATM 6233 O O . HOH J 5 . ? 29.902 -16.528 73.597 1.00 22.04 ? 826 HOH A O 1 HETATM 6234 O O . HOH J 5 . ? 20.633 -27.622 38.035 1.00 15.22 ? 827 HOH A O 1 HETATM 6235 O O . HOH J 5 . ? 22.257 -15.554 -24.401 1.00 16.92 ? 828 HOH A O 1 HETATM 6236 O O . HOH J 5 . ? 27.295 -31.871 59.594 1.00 16.15 ? 829 HOH A O 1 HETATM 6237 O O . HOH J 5 . ? 26.460 -31.877 25.083 1.00 19.05 ? 830 HOH A O 1 HETATM 6238 O O . HOH J 5 . ? 30.571 -28.159 48.941 1.00 23.41 ? 831 HOH A O 1 HETATM 6239 O O . HOH J 5 . ? 8.477 -35.155 49.835 1.00 15.63 ? 832 HOH A O 1 HETATM 6240 O O . HOH J 5 . ? 25.327 -33.095 59.571 1.00 24.57 ? 833 HOH A O 1 HETATM 6241 O O . HOH J 5 . ? 9.670 -39.021 63.362 1.00 38.24 ? 834 HOH A O 1 HETATM 6242 O O . HOH J 5 . ? 18.850 -33.092 27.089 1.00 31.76 ? 835 HOH A O 1 HETATM 6243 O O . HOH J 5 . ? 16.785 -8.576 67.239 1.00 25.55 ? 836 HOH A O 1 HETATM 6244 O O . HOH J 5 . ? 36.425 -11.920 66.544 1.00 21.68 ? 837 HOH A O 1 HETATM 6245 O O . HOH J 5 . ? 21.008 -8.644 41.626 1.00 20.33 ? 838 HOH A O 1 HETATM 6246 O O . HOH J 5 . ? 36.279 -29.164 27.212 1.00 23.67 ? 839 HOH A O 1 HETATM 6247 O O . HOH J 5 . ? 41.775 -9.624 -21.814 1.00 18.46 ? 840 HOH A O 1 HETATM 6248 O O . HOH J 5 . ? 23.093 -31.476 37.124 1.00 23.99 ? 841 HOH A O 1 HETATM 6249 O O . HOH J 5 . ? 23.086 -40.264 27.861 1.00 25.36 ? 842 HOH A O 1 HETATM 6250 O O . HOH J 5 . ? 33.536 -12.216 -6.297 1.00 32.13 ? 843 HOH A O 1 HETATM 6251 O O . HOH J 5 . ? 11.328 -25.951 21.076 1.00 51.53 ? 844 HOH A O 1 HETATM 6252 O O . HOH J 5 . ? 24.414 -7.006 17.261 1.00 62.72 ? 845 HOH A O 1 HETATM 6253 O O . HOH J 5 . ? 18.700 -6.966 42.470 1.00 48.87 ? 846 HOH A O 1 HETATM 6254 O O . HOH J 5 . ? 11.024 -31.553 51.108 1.00 20.58 ? 847 HOH A O 1 HETATM 6255 O O . HOH J 5 . ? 22.893 -39.719 30.731 1.00 21.93 ? 848 HOH A O 1 HETATM 6256 O O . HOH J 5 . ? 14.344 -19.848 -15.305 1.00 51.15 ? 849 HOH A O 1 HETATM 6257 O O . HOH J 5 . ? 33.759 -21.451 -1.552 1.00 25.11 ? 850 HOH A O 1 HETATM 6258 O O . HOH J 5 . ? 36.259 -25.022 50.669 1.00 24.91 ? 851 HOH A O 1 HETATM 6259 O O . HOH J 5 . ? 35.995 -15.531 46.135 1.00 42.36 ? 852 HOH A O 1 HETATM 6260 O O . HOH J 5 . ? 21.731 -5.646 37.460 1.00 28.04 ? 853 HOH A O 1 HETATM 6261 O O . HOH J 5 . ? 18.571 -10.591 -10.357 1.00 34.03 ? 854 HOH A O 1 HETATM 6262 O O . HOH J 5 . ? 32.039 -22.757 36.823 1.00 23.12 ? 855 HOH A O 1 HETATM 6263 O O . HOH J 5 . ? 14.178 -14.875 29.200 1.00 56.82 ? 856 HOH A O 1 HETATM 6264 O O . HOH J 5 . ? 25.492 -28.226 56.091 1.00 36.86 ? 857 HOH A O 1 HETATM 6265 O O . HOH J 5 . ? 23.207 -20.199 -25.090 1.00 61.26 ? 858 HOH A O 1 HETATM 6266 O O . HOH J 5 . ? 31.941 -18.606 71.784 1.00 46.63 ? 859 HOH A O 1 HETATM 6267 O O . HOH J 5 . ? 11.861 -20.060 46.908 1.00 39.03 ? 860 HOH A O 1 HETATM 6268 O O . HOH J 5 . ? 30.710 -27.684 41.839 1.00 48.65 ? 861 HOH A O 1 HETATM 6269 O O . HOH J 5 . ? 24.395 -26.963 36.023 1.00 27.39 ? 862 HOH A O 1 HETATM 6270 O O . HOH J 5 . ? 29.163 -9.141 12.573 1.00 32.85 ? 863 HOH A O 1 HETATM 6271 O O . HOH J 5 . ? 16.283 -15.321 52.127 1.00 38.48 ? 864 HOH A O 1 HETATM 6272 O O . HOH J 5 . ? 14.227 -20.264 23.355 1.00 24.47 ? 865 HOH A O 1 HETATM 6273 O O . HOH J 5 . ? 13.231 -26.660 48.270 1.00 48.82 ? 866 HOH A O 1 HETATM 6274 O O . HOH J 5 . ? 34.116 -16.372 40.946 1.00 29.80 ? 867 HOH A O 1 HETATM 6275 O O . HOH J 5 . ? 33.730 -17.434 73.699 1.00 69.11 ? 868 HOH A O 1 HETATM 6276 O O . HOH J 5 . ? 31.189 -2.480 54.110 1.00 43.65 ? 869 HOH A O 1 HETATM 6277 O O . HOH J 5 . ? 20.189 -41.863 60.824 1.00 39.41 ? 870 HOH A O 1 HETATM 6278 O O . HOH J 5 . ? 36.510 -25.713 25.072 1.00 24.81 ? 871 HOH A O 1 HETATM 6279 O O . HOH J 5 . ? 10.800 -27.238 22.815 1.00 32.80 ? 872 HOH A O 1 HETATM 6280 O O . HOH J 5 . ? 33.992 -5.942 -20.291 1.00 28.95 ? 873 HOH A O 1 HETATM 6281 O O . HOH J 5 . ? 29.413 -10.489 61.879 1.00 19.25 ? 874 HOH A O 1 HETATM 6282 O O . HOH J 5 . ? 12.171 -49.966 42.395 1.00 75.66 ? 875 HOH A O 1 HETATM 6283 O O . HOH J 5 . ? 25.678 -33.623 22.169 1.00 19.40 ? 876 HOH A O 1 HETATM 6284 O O . HOH J 5 . ? 30.753 -1.952 59.543 1.00 48.14 ? 877 HOH A O 1 HETATM 6285 O O . HOH J 5 . ? 11.322 -29.805 48.965 1.00 24.45 ? 878 HOH A O 1 HETATM 6286 O O . HOH J 5 . ? 35.013 -18.483 39.823 1.00 28.04 ? 879 HOH A O 1 HETATM 6287 O O . HOH J 5 . ? 23.470 -18.786 -28.688 1.00 68.12 ? 880 HOH A O 1 HETATM 6288 O O . HOH J 5 . ? 31.232 -24.327 35.683 1.00 19.09 ? 881 HOH A O 1 HETATM 6289 O O . HOH J 5 . ? 11.218 -27.279 48.782 1.00 38.42 ? 882 HOH A O 1 HETATM 6290 O O . HOH J 5 . ? 40.242 -8.122 -19.502 1.00 37.19 ? 883 HOH A O 1 HETATM 6291 O O . HOH J 5 . ? 12.454 -6.503 53.844 1.00 33.49 ? 884 HOH A O 1 HETATM 6292 O O . HOH J 5 . ? 32.429 -24.461 5.950 1.00 55.88 ? 885 HOH A O 1 HETATM 6293 O O . HOH J 5 . ? 12.547 -26.776 57.922 1.00 28.19 ? 886 HOH A O 1 HETATM 6294 O O . HOH J 5 . ? 13.188 -19.405 7.360 1.00 27.50 ? 887 HOH A O 1 HETATM 6295 O O . HOH J 5 . ? 19.528 -2.189 -1.849 1.00 38.43 ? 888 HOH A O 1 HETATM 6296 O O . HOH J 5 . ? 32.472 -14.170 -5.410 1.00 25.48 ? 889 HOH A O 1 HETATM 6297 O O . HOH J 5 . ? 32.055 -18.931 35.373 1.00 40.05 ? 890 HOH A O 1 HETATM 6298 O O . HOH J 5 . ? 11.255 -13.538 6.488 1.00 62.92 ? 891 HOH A O 1 HETATM 6299 O O . HOH J 5 . ? 24.513 -35.805 29.039 1.00 21.13 ? 892 HOH A O 1 HETATM 6300 O O . HOH J 5 . ? 28.687 -29.193 44.855 1.00 42.96 ? 893 HOH A O 1 HETATM 6301 O O . HOH J 5 . ? 24.849 -32.701 53.205 1.00 52.92 ? 894 HOH A O 1 HETATM 6302 O O . HOH J 5 . ? 26.044 -30.857 5.815 1.00 62.29 ? 895 HOH A O 1 HETATM 6303 O O . HOH J 5 . ? 15.122 -3.665 -10.442 1.00 44.11 ? 896 HOH A O 1 HETATM 6304 O O . HOH J 5 . ? 11.874 -28.772 57.583 1.00 49.45 ? 897 HOH A O 1 HETATM 6305 O O . HOH J 5 . ? 21.748 -28.564 3.628 1.00 54.08 ? 898 HOH A O 1 HETATM 6306 O O . HOH J 5 . ? 21.377 -17.700 -25.529 1.00 36.40 ? 899 HOH A O 1 HETATM 6307 O O . HOH J 5 . ? 35.956 -15.008 -9.611 1.00 59.30 ? 900 HOH A O 1 HETATM 6308 O O . HOH J 5 . ? 26.984 -1.095 53.087 1.00 31.24 ? 901 HOH A O 1 HETATM 6309 O O . HOH J 5 . ? 22.510 -9.358 16.856 1.00 44.07 ? 902 HOH A O 1 HETATM 6310 O O . HOH J 5 . ? 21.367 -20.359 -25.248 1.00 72.93 ? 903 HOH A O 1 HETATM 6311 O O . HOH J 5 . ? 6.647 -31.911 40.105 1.00 54.55 ? 904 HOH A O 1 HETATM 6312 O O . HOH J 5 . ? 21.578 -0.676 -3.059 1.00 46.96 ? 905 HOH A O 1 HETATM 6313 O O . HOH J 5 . ? 34.874 -23.079 50.355 1.00 37.70 ? 906 HOH A O 1 HETATM 6314 O O . HOH J 5 . ? 10.711 -22.626 13.049 1.00 55.35 ? 907 HOH A O 1 HETATM 6315 O O . HOH J 5 . ? 40.275 -9.339 -16.554 1.00 39.37 ? 908 HOH A O 1 HETATM 6316 O O . HOH J 5 . ? 17.066 -15.266 13.300 1.00 27.58 ? 909 HOH A O 1 HETATM 6317 O O . HOH J 5 . ? 17.081 -11.010 -12.956 1.00 37.42 ? 910 HOH A O 1 HETATM 6318 O O . HOH J 5 . ? 13.594 -20.553 15.902 1.00 21.17 ? 911 HOH A O 1 HETATM 6319 O O . HOH J 5 . ? 7.757 -36.575 60.789 1.00 46.56 ? 912 HOH A O 1 HETATM 6320 O O . HOH J 5 . ? 15.681 -28.238 5.028 1.00 25.04 ? 913 HOH A O 1 HETATM 6321 O O . HOH J 5 . ? 24.759 -55.985 38.356 1.00 63.77 ? 914 HOH A O 1 HETATM 6322 O O . HOH J 5 . ? 24.388 -30.366 24.118 1.00 25.09 ? 915 HOH A O 1 HETATM 6323 O O . HOH J 5 . ? 19.685 -8.389 32.894 1.00 35.26 ? 916 HOH A O 1 HETATM 6324 O O . HOH J 5 . ? 7.980 -40.611 63.042 1.00 32.32 ? 917 HOH A O 1 HETATM 6325 O O . HOH J 5 . ? 27.273 -33.036 54.152 1.00 16.31 ? 918 HOH A O 1 HETATM 6326 O O . HOH J 5 . ? 34.292 -7.206 63.345 1.00 24.47 ? 919 HOH A O 1 HETATM 6327 O O . HOH J 5 . ? 34.083 -40.447 34.096 1.00 32.93 ? 920 HOH A O 1 HETATM 6328 O O . HOH J 5 . ? 38.385 -20.051 -28.741 1.00 19.05 ? 921 HOH A O 1 HETATM 6329 O O . HOH J 5 . ? 19.572 -6.318 57.138 1.00 53.02 ? 922 HOH A O 1 HETATM 6330 O O . HOH J 5 . ? 29.116 -21.373 35.117 1.00 40.46 ? 923 HOH A O 1 HETATM 6331 O O . HOH J 5 . ? 33.755 -18.822 -7.949 1.00 44.49 ? 924 HOH A O 1 HETATM 6332 O O . HOH J 5 . ? 7.695 -37.291 57.400 1.00 24.19 ? 925 HOH A O 1 HETATM 6333 O O . HOH J 5 . ? 21.053 -45.199 48.768 1.00 17.64 ? 926 HOH A O 1 HETATM 6334 O O . HOH J 5 . ? 24.732 -21.587 35.166 1.00 43.33 ? 927 HOH A O 1 HETATM 6335 O O . HOH J 5 . ? 26.793 -33.055 62.130 1.00 55.70 ? 928 HOH A O 1 HETATM 6336 O O . HOH J 5 . ? 33.678 0.061 7.028 1.00 53.81 ? 929 HOH A O 1 HETATM 6337 O O . HOH J 5 . ? 34.422 -22.331 7.870 1.00 51.70 ? 930 HOH A O 1 HETATM 6338 O O . HOH J 5 . ? 28.272 -22.493 -17.142 1.00 23.41 ? 931 HOH A O 1 HETATM 6339 O O . HOH J 5 . ? 27.887 -27.718 51.836 1.00 50.61 ? 932 HOH A O 1 HETATM 6340 O O . HOH J 5 . ? 38.786 -22.393 -28.372 0.33 35.35 ? 933 HOH A O 1 HETATM 6341 O O . HOH J 5 . ? 41.267 -13.432 -14.995 1.00 59.80 ? 934 HOH A O 1 HETATM 6342 O O . HOH J 5 . ? 26.484 -8.117 -11.581 1.00 60.66 ? 935 HOH A O 1 HETATM 6343 O O . HOH J 5 . ? 38.411 -18.793 10.408 1.00 47.23 ? 936 HOH A O 1 HETATM 6344 O O . HOH J 5 . ? 16.566 -25.492 61.434 1.00 56.47 ? 937 HOH A O 1 HETATM 6345 O O . HOH J 5 . ? 31.822 -44.346 40.131 1.00 54.01 ? 938 HOH A O 1 HETATM 6346 O O . HOH J 5 . ? 0.727 -34.727 46.642 1.00 65.07 ? 939 HOH A O 1 HETATM 6347 O O . HOH J 5 . ? 27.735 -60.847 34.566 1.00 55.74 ? 940 HOH A O 1 HETATM 6348 O O . HOH J 5 . ? 14.747 -8.520 58.284 1.00 53.92 ? 941 HOH A O 1 HETATM 6349 O O . HOH J 5 . ? 14.459 -41.469 32.346 1.00 53.28 ? 942 HOH A O 1 HETATM 6350 O O . HOH J 5 . ? 42.018 -11.570 -14.626 1.00 51.57 ? 943 HOH A O 1 HETATM 6351 O O . HOH J 5 . ? 19.867 -4.546 36.733 1.00 43.76 ? 944 HOH A O 1 HETATM 6352 O O . HOH J 5 . ? 20.178 -39.457 26.048 1.00 72.57 ? 945 HOH A O 1 HETATM 6353 O O . HOH J 5 . ? 22.433 -30.286 2.355 1.00 59.67 ? 946 HOH A O 1 HETATM 6354 O O . HOH J 5 . ? 18.673 -10.807 69.398 1.00 73.32 ? 947 HOH A O 1 HETATM 6355 O O . HOH J 5 . ? 2.686 -34.384 44.173 1.00 69.23 ? 948 HOH A O 1 HETATM 6356 O O . HOH J 5 . ? 18.300 -7.711 57.764 1.00 65.23 ? 949 HOH A O 1 HETATM 6357 O O . HOH J 5 . ? 27.348 -22.792 34.966 1.00 57.75 ? 950 HOH A O 1 HETATM 6358 O O . HOH J 5 . ? 20.914 -36.957 26.166 1.00 66.07 ? 951 HOH A O 1 HETATM 6359 O O . HOH J 5 . ? 33.761 -24.837 7.638 1.00 49.23 ? 952 HOH A O 1 HETATM 6360 O O . HOH J 5 . ? 18.243 -3.481 46.968 1.00 70.95 ? 953 HOH A O 1 HETATM 6361 O O . HOH J 5 . ? 33.556 -21.411 39.342 1.00 25.93 ? 954 HOH A O 1 HETATM 6362 O O . HOH J 5 . ? 29.520 2.148 15.243 1.00 44.38 ? 955 HOH A O 1 HETATM 6363 O O . HOH J 5 . ? 29.812 -9.987 -28.167 1.00 58.14 ? 956 HOH A O 1 HETATM 6364 O O . HOH J 5 . ? 13.942 -6.443 55.985 1.00 65.80 ? 957 HOH A O 1 HETATM 6365 O O . HOH J 5 . ? 33.413 -46.763 31.441 1.00 73.74 ? 958 HOH A O 1 HETATM 6366 O O . HOH J 5 . ? 32.560 -11.747 68.148 1.00 50.48 ? 959 HOH A O 1 HETATM 6367 O O . HOH J 5 . ? 38.773 -17.406 37.144 1.00 63.26 ? 960 HOH A O 1 HETATM 6368 O O . HOH K 5 . ? -6.679 -33.287 -25.098 1.00 8.93 ? 601 HOH B O 1 HETATM 6369 O O . HOH K 5 . ? -9.517 -32.784 -18.147 1.00 6.53 ? 602 HOH B O 1 HETATM 6370 O O . HOH K 5 . ? 25.779 -38.816 -33.181 1.00 11.31 ? 603 HOH B O 1 HETATM 6371 O O . HOH K 5 . ? -2.170 -25.734 -25.999 1.00 14.24 ? 604 HOH B O 1 HETATM 6372 O O . HOH K 5 . ? -0.022 -35.794 -24.955 1.00 12.14 ? 605 HOH B O 1 HETATM 6373 O O . HOH K 5 . ? -9.989 -31.316 -42.933 1.00 14.12 ? 606 HOH B O 1 HETATM 6374 O O . HOH K 5 . ? 11.608 -31.932 -28.703 1.00 14.43 ? 607 HOH B O 1 HETATM 6375 O O . HOH K 5 . ? 4.440 -42.840 -53.939 1.00 9.65 ? 608 HOH B O 1 HETATM 6376 O O . HOH K 5 . ? 13.953 -39.864 -24.287 1.00 10.79 ? 609 HOH B O 1 HETATM 6377 O O . HOH K 5 . ? 11.126 -32.554 -24.053 1.00 9.24 ? 610 HOH B O 1 HETATM 6378 O O . HOH K 5 . ? 1.567 -37.904 -31.747 1.00 16.78 ? 611 HOH B O 1 HETATM 6379 O O . HOH K 5 . ? 3.662 -32.182 -37.557 1.00 12.36 ? 612 HOH B O 1 HETATM 6380 O O . HOH K 5 . ? 25.626 -38.388 -38.121 1.00 12.20 ? 613 HOH B O 1 HETATM 6381 O O . HOH K 5 . ? -8.598 -34.648 -35.430 1.00 7.82 ? 614 HOH B O 1 HETATM 6382 O O . HOH K 5 . ? 10.570 -35.259 -19.562 1.00 10.46 ? 615 HOH B O 1 HETATM 6383 O O . HOH K 5 . ? 8.421 -37.729 -28.758 1.00 11.45 ? 616 HOH B O 1 HETATM 6384 O O . HOH K 5 . ? 19.312 -44.326 -34.303 1.00 16.49 ? 617 HOH B O 1 HETATM 6385 O O . HOH K 5 . ? -8.232 -30.904 -34.686 1.00 10.44 ? 618 HOH B O 1 HETATM 6386 O O . HOH K 5 . ? 31.511 -22.479 -53.357 1.00 21.90 ? 619 HOH B O 1 HETATM 6387 O O . HOH K 5 . ? 3.986 -25.327 -39.167 1.00 9.36 ? 620 HOH B O 1 HETATM 6388 O O . HOH K 5 . ? 7.302 -29.884 -60.864 1.00 17.71 ? 621 HOH B O 1 HETATM 6389 O O . HOH K 5 . ? 23.243 -25.467 -37.253 1.00 13.24 ? 622 HOH B O 1 HETATM 6390 O O . HOH K 5 . ? 7.302 -33.835 -53.730 1.00 13.64 ? 623 HOH B O 1 HETATM 6391 O O . HOH K 5 . ? -11.520 -37.479 -26.399 1.00 15.82 ? 624 HOH B O 1 HETATM 6392 O O . HOH K 5 . ? -12.651 -31.991 -45.285 1.00 12.08 ? 625 HOH B O 1 HETATM 6393 O O . HOH K 5 . ? 17.735 -42.173 -33.024 1.00 14.43 ? 626 HOH B O 1 HETATM 6394 O O . HOH K 5 . ? -9.217 -36.661 -30.347 1.00 9.37 ? 627 HOH B O 1 HETATM 6395 O O . HOH K 5 . ? -9.093 -19.488 -47.956 1.00 15.05 ? 628 HOH B O 1 HETATM 6396 O O . HOH K 5 . ? 21.281 -25.399 -35.223 1.00 29.74 ? 629 HOH B O 1 HETATM 6397 O O . HOH K 5 . ? 31.995 -37.718 -33.902 1.00 15.08 ? 630 HOH B O 1 HETATM 6398 O O . HOH K 5 . ? 7.933 -32.703 -51.214 1.00 14.81 ? 631 HOH B O 1 HETATM 6399 O O . HOH K 5 . ? 27.966 -27.494 -34.138 1.00 17.34 ? 632 HOH B O 1 HETATM 6400 O O . HOH K 5 . ? -9.279 -29.899 -19.114 1.00 10.82 ? 633 HOH B O 1 HETATM 6401 O O . HOH K 5 . ? 17.173 -31.988 -10.579 1.00 25.23 ? 634 HOH B O 1 HETATM 6402 O O . HOH K 5 . ? 16.587 -38.242 -24.078 1.00 16.02 ? 635 HOH B O 1 HETATM 6403 O O . HOH K 5 . ? 11.032 -33.241 -17.878 1.00 7.74 ? 636 HOH B O 1 HETATM 6404 O O . HOH K 5 . ? 0.482 -39.184 2.347 1.00 27.31 ? 637 HOH B O 1 HETATM 6405 O O . HOH K 5 . ? 25.154 -48.421 -43.985 1.00 16.83 ? 638 HOH B O 1 HETATM 6406 O O . HOH K 5 . ? 21.633 -20.443 -48.796 1.00 16.17 ? 639 HOH B O 1 HETATM 6407 O O . HOH K 5 . ? -6.107 -39.017 -29.524 1.00 12.12 ? 640 HOH B O 1 HETATM 6408 O O . HOH K 5 . ? 34.531 -29.252 -42.062 1.00 21.10 ? 641 HOH B O 1 HETATM 6409 O O . HOH K 5 . ? -12.983 -28.634 -48.389 1.00 22.83 ? 642 HOH B O 1 HETATM 6410 O O . HOH K 5 . ? 17.310 -36.369 -28.125 1.00 15.39 ? 643 HOH B O 1 HETATM 6411 O O . HOH K 5 . ? -6.918 -25.077 18.471 1.00 32.54 ? 644 HOH B O 1 HETATM 6412 O O . HOH K 5 . ? 9.497 -39.114 -30.902 1.00 15.01 ? 645 HOH B O 1 HETATM 6413 O O . HOH K 5 . ? 4.579 -38.311 -34.610 1.00 16.49 ? 646 HOH B O 1 HETATM 6414 O O . HOH K 5 . ? -3.596 -38.564 -26.660 1.00 16.18 ? 647 HOH B O 1 HETATM 6415 O O . HOH K 5 . ? 10.635 -33.635 -26.712 1.00 17.15 ? 648 HOH B O 1 HETATM 6416 O O . HOH K 5 . ? -4.099 -35.593 -40.956 1.00 12.27 ? 649 HOH B O 1 HETATM 6417 O O . HOH K 5 . ? -7.818 -39.705 -27.465 1.00 16.09 ? 650 HOH B O 1 HETATM 6418 O O . HOH K 5 . ? 36.328 -41.372 -32.097 1.00 52.07 ? 651 HOH B O 1 HETATM 6419 O O . HOH K 5 . ? 13.648 -24.088 -56.701 1.00 20.39 ? 652 HOH B O 1 HETATM 6420 O O . HOH K 5 . ? 12.997 -36.828 -24.288 1.00 15.78 ? 653 HOH B O 1 HETATM 6421 O O . HOH K 5 . ? 27.863 -43.961 -33.718 1.00 17.50 ? 654 HOH B O 1 HETATM 6422 O O . HOH K 5 . ? 5.588 -21.697 -44.139 1.00 18.79 ? 655 HOH B O 1 HETATM 6423 O O . HOH K 5 . ? 2.794 -44.288 -19.486 1.00 28.69 ? 656 HOH B O 1 HETATM 6424 O O . HOH K 5 . ? 13.907 -29.914 -64.665 1.00 24.97 ? 657 HOH B O 1 HETATM 6425 O O . HOH K 5 . ? 13.791 -24.540 -16.171 1.00 23.43 ? 658 HOH B O 1 HETATM 6426 O O . HOH K 5 . ? 19.428 -27.499 -60.458 1.00 26.57 ? 659 HOH B O 1 HETATM 6427 O O . HOH K 5 . ? -9.711 -41.942 -67.106 1.00 19.33 ? 660 HOH B O 1 HETATM 6428 O O . HOH K 5 . ? -13.625 -30.503 18.487 1.00 25.78 ? 661 HOH B O 1 HETATM 6429 O O . HOH K 5 . ? -0.280 -43.760 -24.520 1.00 38.13 ? 662 HOH B O 1 HETATM 6430 O O . HOH K 5 . ? 4.748 -24.964 -0.911 1.00 26.07 ? 663 HOH B O 1 HETATM 6431 O O . HOH K 5 . ? 28.306 -29.806 -52.532 1.00 20.92 ? 664 HOH B O 1 HETATM 6432 O O . HOH K 5 . ? -7.896 -35.149 -67.387 1.00 18.34 ? 665 HOH B O 1 HETATM 6433 O O . HOH K 5 . ? -7.576 -39.446 24.769 1.00 24.10 ? 666 HOH B O 1 HETATM 6434 O O . HOH K 5 . ? 22.358 -23.289 -32.354 1.00 17.07 ? 667 HOH B O 1 HETATM 6435 O O . HOH K 5 . ? -7.085 -23.251 -41.081 1.00 34.78 ? 668 HOH B O 1 HETATM 6436 O O . HOH K 5 . ? -11.942 -43.314 21.924 1.00 32.64 ? 669 HOH B O 1 HETATM 6437 O O . HOH K 5 . ? 13.730 -33.358 -16.988 1.00 15.94 ? 670 HOH B O 1 HETATM 6438 O O . HOH K 5 . ? 30.869 -28.714 -50.190 1.00 28.02 ? 671 HOH B O 1 HETATM 6439 O O . HOH K 5 . ? 22.710 -19.766 -59.655 1.00 28.84 ? 672 HOH B O 1 HETATM 6440 O O . HOH K 5 . ? -12.339 -39.360 12.791 1.00 33.42 ? 673 HOH B O 1 HETATM 6441 O O . HOH K 5 . ? -1.032 -41.498 -31.687 1.00 63.73 ? 674 HOH B O 1 HETATM 6442 O O . HOH K 5 . ? 8.508 -28.482 -48.115 1.00 17.14 ? 675 HOH B O 1 HETATM 6443 O O . HOH K 5 . ? -11.847 -31.571 -62.152 1.00 18.57 ? 676 HOH B O 1 HETATM 6444 O O . HOH K 5 . ? -12.400 -37.250 -49.675 1.00 39.55 ? 677 HOH B O 1 HETATM 6445 O O . HOH K 5 . ? -0.712 -43.869 34.220 1.00 45.59 ? 678 HOH B O 1 HETATM 6446 O O . HOH K 5 . ? 18.147 -34.948 -11.206 1.00 43.77 ? 679 HOH B O 1 HETATM 6447 O O . HOH K 5 . ? 13.253 -29.873 -42.329 1.00 18.63 ? 680 HOH B O 1 HETATM 6448 O O . HOH K 5 . ? 19.482 -17.831 -38.257 1.00 34.94 ? 681 HOH B O 1 HETATM 6449 O O . HOH K 5 . ? -14.521 -37.686 21.284 1.00 48.87 ? 682 HOH B O 1 HETATM 6450 O O . HOH K 5 . ? -3.554 -24.309 -38.160 1.00 13.10 ? 683 HOH B O 1 HETATM 6451 O O . HOH K 5 . ? 32.891 -40.907 -27.136 1.00 20.57 ? 684 HOH B O 1 HETATM 6452 O O . HOH K 5 . ? 25.640 -32.467 -60.286 1.00 22.41 ? 685 HOH B O 1 HETATM 6453 O O . HOH K 5 . ? 10.752 -19.144 -11.017 1.00 56.91 ? 686 HOH B O 1 HETATM 6454 O O . HOH K 5 . ? 16.250 -27.551 -30.591 1.00 22.83 ? 687 HOH B O 1 HETATM 6455 O O . HOH K 5 . ? -5.863 -40.002 18.343 1.00 28.60 ? 688 HOH B O 1 HETATM 6456 O O . HOH K 5 . ? 3.175 -38.904 22.808 1.00 28.22 ? 689 HOH B O 1 HETATM 6457 O O . HOH K 5 . ? 15.194 -24.489 -44.975 1.00 20.80 ? 690 HOH B O 1 HETATM 6458 O O . HOH K 5 . ? 6.592 -14.176 -33.140 1.00 41.51 ? 691 HOH B O 1 HETATM 6459 O O . HOH K 5 . ? 29.241 -24.135 -57.374 1.00 24.24 ? 692 HOH B O 1 HETATM 6460 O O . HOH K 5 . ? 7.873 -16.330 -33.703 1.00 35.35 ? 693 HOH B O 1 HETATM 6461 O O . HOH K 5 . ? 12.975 -35.113 -3.927 1.00 39.23 ? 694 HOH B O 1 HETATM 6462 O O . HOH K 5 . ? 26.246 -30.597 -62.595 1.00 33.00 ? 695 HOH B O 1 HETATM 6463 O O . HOH K 5 . ? -1.002 -35.068 6.779 1.00 55.03 ? 696 HOH B O 1 HETATM 6464 O O . HOH K 5 . ? 13.579 -39.684 -44.275 1.00 16.31 ? 697 HOH B O 1 HETATM 6465 O O . HOH K 5 . ? 21.569 -35.883 -29.602 1.00 17.01 ? 698 HOH B O 1 HETATM 6466 O O . HOH K 5 . ? 18.871 -35.510 -30.578 1.00 20.46 ? 699 HOH B O 1 HETATM 6467 O O . HOH K 5 . ? -7.288 -25.066 -68.815 1.00 41.23 ? 700 HOH B O 1 HETATM 6468 O O . HOH K 5 . ? 2.064 -35.938 -34.476 1.00 17.85 ? 701 HOH B O 1 HETATM 6469 O O . HOH K 5 . ? -3.644 -35.233 39.493 1.00 20.23 ? 702 HOH B O 1 HETATM 6470 O O . HOH K 5 . ? -5.360 -23.607 -17.866 1.00 36.08 ? 703 HOH B O 1 HETATM 6471 O O . HOH K 5 . ? -13.491 -39.482 -36.666 1.00 14.28 ? 704 HOH B O 1 HETATM 6472 O O . HOH K 5 . ? -9.361 -29.370 -15.500 1.00 26.30 ? 705 HOH B O 1 HETATM 6473 O O . HOH K 5 . ? 9.631 -39.288 -9.680 1.00 19.19 ? 706 HOH B O 1 HETATM 6474 O O . HOH K 5 . ? 3.896 -43.915 -24.114 1.00 20.52 ? 707 HOH B O 1 HETATM 6475 O O . HOH K 5 . ? 9.696 -37.772 -40.148 1.00 26.41 ? 708 HOH B O 1 HETATM 6476 O O . HOH K 5 . ? 12.441 -34.601 -21.952 1.00 14.47 ? 709 HOH B O 1 HETATM 6477 O O . HOH K 5 . ? -17.169 -28.046 -57.844 1.00 19.58 ? 710 HOH B O 1 HETATM 6478 O O . HOH K 5 . ? 31.890 -44.039 -30.623 1.00 29.46 ? 711 HOH B O 1 HETATM 6479 O O . HOH K 5 . ? 34.261 -45.159 -27.881 1.00 30.61 ? 712 HOH B O 1 HETATM 6480 O O . HOH K 5 . ? 33.934 -43.668 -29.545 1.00 38.51 ? 713 HOH B O 1 HETATM 6481 O O . HOH K 5 . ? 5.235 -26.162 -46.754 1.00 10.87 ? 714 HOH B O 1 HETATM 6482 O O . HOH K 5 . ? 6.475 -25.305 -60.753 1.00 21.97 ? 715 HOH B O 1 HETATM 6483 O O . HOH K 5 . ? -3.022 -25.185 -23.500 1.00 16.64 ? 716 HOH B O 1 HETATM 6484 O O . HOH K 5 . ? 8.178 -27.374 -60.723 1.00 16.60 ? 717 HOH B O 1 HETATM 6485 O O . HOH K 5 . ? 14.908 -30.333 -8.890 1.00 20.61 ? 718 HOH B O 1 HETATM 6486 O O . HOH K 5 . ? 17.446 -34.740 -64.804 1.00 42.06 ? 719 HOH B O 1 HETATM 6487 O O . HOH K 5 . ? -9.607 -18.711 -45.249 1.00 32.04 ? 720 HOH B O 1 HETATM 6488 O O . HOH K 5 . ? 30.964 -27.783 -48.107 1.00 19.30 ? 721 HOH B O 1 HETATM 6489 O O . HOH K 5 . ? 15.750 -35.920 -50.456 1.00 22.36 ? 722 HOH B O 1 HETATM 6490 O O . HOH K 5 . ? 25.998 -27.917 -30.262 1.00 26.59 ? 723 HOH B O 1 HETATM 6491 O O . HOH K 5 . ? -8.272 -32.047 -60.938 1.00 20.94 ? 724 HOH B O 1 HETATM 6492 O O . HOH K 5 . ? 18.961 -36.726 -64.112 1.00 35.75 ? 725 HOH B O 1 HETATM 6493 O O . HOH K 5 . ? 4.500 -34.474 -34.228 1.00 20.72 ? 726 HOH B O 1 HETATM 6494 O O . HOH K 5 . ? -8.274 -34.027 6.856 1.00 34.84 ? 727 HOH B O 1 HETATM 6495 O O . HOH K 5 . ? 11.095 -22.728 -40.479 1.00 47.79 ? 728 HOH B O 1 HETATM 6496 O O . HOH K 5 . ? -15.915 -33.117 -18.363 1.00 15.99 ? 729 HOH B O 1 HETATM 6497 O O . HOH K 5 . ? -1.634 -32.779 -69.836 1.00 13.91 ? 730 HOH B O 1 HETATM 6498 O O . HOH K 5 . ? 17.617 -40.945 -17.347 1.00 13.18 ? 731 HOH B O 1 HETATM 6499 O O . HOH K 5 . ? 0.568 -21.595 -51.865 1.00 13.13 ? 732 HOH B O 1 HETATM 6500 O O . HOH K 5 . ? 8.327 -20.592 -56.626 1.00 16.88 ? 733 HOH B O 1 HETATM 6501 O O . HOH K 5 . ? 27.736 -35.038 -48.006 1.00 19.84 ? 734 HOH B O 1 HETATM 6502 O O . HOH K 5 . ? 5.878 -20.194 -56.854 1.00 17.72 ? 735 HOH B O 1 HETATM 6503 O O . HOH K 5 . ? 8.333 -34.396 -66.368 1.00 20.46 ? 736 HOH B O 1 HETATM 6504 O O . HOH K 5 . ? 7.528 -21.951 16.306 1.00 36.03 ? 737 HOH B O 1 HETATM 6505 O O . HOH K 5 . ? 32.623 -22.931 -55.895 1.00 32.20 ? 738 HOH B O 1 HETATM 6506 O O . HOH K 5 . ? 10.625 -23.098 -50.068 1.00 18.42 ? 739 HOH B O 1 HETATM 6507 O O . HOH K 5 . ? 22.672 -43.158 -49.822 1.00 41.44 ? 740 HOH B O 1 HETATM 6508 O O . HOH K 5 . ? 5.165 -40.495 1.557 1.00 48.70 ? 741 HOH B O 1 HETATM 6509 O O . HOH K 5 . ? 13.834 -24.698 -19.478 1.00 26.69 ? 742 HOH B O 1 HETATM 6510 O O . HOH K 5 . ? -4.096 -37.448 41.853 1.00 25.48 ? 743 HOH B O 1 HETATM 6511 O O . HOH K 5 . ? -14.006 -30.230 -47.534 1.00 36.54 ? 744 HOH B O 1 HETATM 6512 O O . HOH K 5 . ? 19.474 -44.905 -22.194 1.00 14.61 ? 745 HOH B O 1 HETATM 6513 O O . HOH K 5 . ? 23.845 -35.795 -26.495 1.00 20.24 ? 746 HOH B O 1 HETATM 6514 O O . HOH K 5 . ? -8.002 -30.704 -0.976 1.00 36.04 ? 747 HOH B O 1 HETATM 6515 O O . HOH K 5 . ? -13.708 -34.021 -26.656 1.00 26.34 ? 748 HOH B O 1 HETATM 6516 O O . HOH K 5 . ? -5.334 -19.595 -35.105 1.00 26.09 ? 749 HOH B O 1 HETATM 6517 O O . HOH K 5 . ? 12.878 -34.924 -61.932 1.00 18.86 ? 750 HOH B O 1 HETATM 6518 O O . HOH K 5 . ? -4.302 -21.737 -20.555 1.00 34.91 ? 751 HOH B O 1 HETATM 6519 O O . HOH K 5 . ? -6.869 -21.584 -54.878 1.00 42.56 ? 752 HOH B O 1 HETATM 6520 O O . HOH K 5 . ? -12.918 -44.610 24.216 1.00 34.32 ? 753 HOH B O 1 HETATM 6521 O O . HOH K 5 . ? -2.626 -36.756 43.999 1.00 33.62 ? 754 HOH B O 1 HETATM 6522 O O . HOH K 5 . ? -8.499 -20.058 -66.184 1.00 51.63 ? 755 HOH B O 1 HETATM 6523 O O . HOH K 5 . ? 11.373 -30.311 -46.867 1.00 34.13 ? 756 HOH B O 1 HETATM 6524 O O . HOH K 5 . ? 7.505 -19.005 -1.973 1.00 29.95 ? 757 HOH B O 1 HETATM 6525 O O . HOH K 5 . ? -4.636 -21.153 3.525 1.00 31.91 ? 758 HOH B O 1 HETATM 6526 O O . HOH K 5 . ? 3.293 -23.398 -37.044 1.00 24.30 ? 759 HOH B O 1 HETATM 6527 O O . HOH K 5 . ? 26.534 -28.271 -61.639 1.00 41.91 ? 760 HOH B O 1 HETATM 6528 O O . HOH K 5 . ? 28.056 -33.695 -60.254 1.00 41.36 ? 761 HOH B O 1 HETATM 6529 O O . HOH K 5 . ? 18.746 -13.809 -53.933 1.00 35.81 ? 762 HOH B O 1 HETATM 6530 O O . HOH K 5 . ? -7.513 -17.289 -48.710 1.00 37.79 ? 763 HOH B O 1 HETATM 6531 O O . HOH K 5 . ? 10.952 -31.956 -34.837 1.00 59.13 ? 764 HOH B O 1 HETATM 6532 O O . HOH K 5 . ? 16.122 -21.567 -48.195 1.00 27.57 ? 765 HOH B O 1 HETATM 6533 O O . HOH K 5 . ? 27.377 -46.608 -48.789 1.00 40.34 ? 766 HOH B O 1 HETATM 6534 O O . HOH K 5 . ? -3.330 -15.235 -56.473 1.00 68.27 ? 767 HOH B O 1 HETATM 6535 O O . HOH K 5 . ? 30.288 -23.010 -30.593 1.00 21.87 ? 768 HOH B O 1 HETATM 6536 O O . HOH K 5 . ? -5.983 -40.179 -45.177 1.00 23.17 ? 769 HOH B O 1 HETATM 6537 O O . HOH K 5 . ? -9.494 -25.722 -23.080 1.00 24.55 ? 770 HOH B O 1 HETATM 6538 O O . HOH K 5 . ? 9.567 -38.107 -12.044 1.00 15.29 ? 771 HOH B O 1 HETATM 6539 O O . HOH K 5 . ? 34.350 -24.390 -55.657 1.00 73.72 ? 772 HOH B O 1 HETATM 6540 O O . HOH K 5 . ? 17.866 -21.761 -50.082 1.00 19.47 ? 773 HOH B O 1 HETATM 6541 O O . HOH K 5 . ? 18.727 -38.215 -27.432 1.00 30.76 ? 774 HOH B O 1 HETATM 6542 O O . HOH K 5 . ? -10.845 -12.952 7.782 1.00 48.36 ? 775 HOH B O 1 HETATM 6543 O O . HOH K 5 . ? -4.191 -35.080 25.007 1.00 32.21 ? 776 HOH B O 1 HETATM 6544 O O . HOH K 5 . ? 4.316 -20.703 -37.638 1.00 30.55 ? 777 HOH B O 1 HETATM 6545 O O . HOH K 5 . ? 6.916 -39.757 -41.176 1.00 19.92 ? 778 HOH B O 1 HETATM 6546 O O . HOH K 5 . ? 2.467 -20.214 -50.768 1.00 26.70 ? 779 HOH B O 1 HETATM 6547 O O . HOH K 5 . ? 14.674 -26.777 -21.051 1.00 45.89 ? 780 HOH B O 1 HETATM 6548 O O . HOH K 5 . ? 15.533 -32.867 -19.066 1.00 21.49 ? 781 HOH B O 1 HETATM 6549 O O . HOH K 5 . ? -5.929 -26.128 -22.542 1.00 18.10 ? 782 HOH B O 1 HETATM 6550 O O . HOH K 5 . ? 7.098 -17.532 -9.983 1.00 23.31 ? 783 HOH B O 1 HETATM 6551 O O . HOH K 5 . ? 12.811 -37.147 -58.925 1.00 16.59 ? 784 HOH B O 1 HETATM 6552 O O . HOH K 5 . ? -3.132 -39.650 40.320 1.00 28.94 ? 785 HOH B O 1 HETATM 6553 O O . HOH K 5 . ? -4.967 -19.054 -55.714 1.00 31.28 ? 786 HOH B O 1 HETATM 6554 O O . HOH K 5 . ? -5.739 -26.812 -32.958 1.00 14.19 ? 787 HOH B O 1 HETATM 6555 O O . HOH K 5 . ? 24.835 -49.716 -41.677 1.00 37.59 ? 788 HOH B O 1 HETATM 6556 O O . HOH K 5 . ? 12.841 -30.084 -39.568 1.00 32.41 ? 789 HOH B O 1 HETATM 6557 O O . HOH K 5 . ? -1.419 -37.963 -31.111 1.00 33.91 ? 790 HOH B O 1 HETATM 6558 O O . HOH K 5 . ? 25.925 -15.806 -42.399 1.00 29.36 ? 791 HOH B O 1 HETATM 6559 O O . HOH K 5 . ? 14.365 -20.567 -18.832 1.00 44.99 ? 792 HOH B O 1 HETATM 6560 O O . HOH K 5 . ? 9.638 -33.918 -55.530 1.00 29.75 ? 793 HOH B O 1 HETATM 6561 O O . HOH K 5 . ? 8.367 -20.303 -47.725 1.00 24.56 ? 794 HOH B O 1 HETATM 6562 O O . HOH K 5 . ? 5.213 -34.426 -37.131 1.00 23.16 ? 795 HOH B O 1 HETATM 6563 O O . HOH K 5 . ? 23.387 -20.763 -31.778 1.00 18.85 ? 796 HOH B O 1 HETATM 6564 O O . HOH K 5 . ? 7.496 -32.998 0.073 1.00 47.40 ? 797 HOH B O 1 HETATM 6565 O O . HOH K 5 . ? -6.447 -20.842 -33.443 1.00 23.44 ? 798 HOH B O 1 HETATM 6566 O O . HOH K 5 . ? 4.805 -21.633 0.993 1.00 27.10 ? 799 HOH B O 1 HETATM 6567 O O . HOH K 5 . ? 25.491 -49.076 -39.377 1.00 28.92 ? 800 HOH B O 1 HETATM 6568 O O . HOH K 5 . ? 6.846 -41.823 -19.770 1.00 15.07 ? 801 HOH B O 1 HETATM 6569 O O . HOH K 5 . ? 25.331 -43.099 -26.619 1.00 17.98 ? 802 HOH B O 1 HETATM 6570 O O . HOH K 5 . ? -6.467 -24.748 -3.181 1.00 25.49 ? 803 HOH B O 1 HETATM 6571 O O . HOH K 5 . ? 7.147 -42.169 -41.458 1.00 70.74 ? 804 HOH B O 1 HETATM 6572 O O . HOH K 5 . ? -11.823 -26.423 -64.258 1.00 30.08 ? 805 HOH B O 1 HETATM 6573 O O . HOH K 5 . ? 11.985 -28.609 -40.973 1.00 68.56 ? 806 HOH B O 1 HETATM 6574 O O . HOH K 5 . ? 22.958 -47.230 -38.241 1.00 25.26 ? 807 HOH B O 1 HETATM 6575 O O . HOH K 5 . ? 11.158 -32.398 -54.597 1.00 22.66 ? 808 HOH B O 1 HETATM 6576 O O . HOH K 5 . ? -2.725 -30.034 35.808 1.00 27.51 ? 809 HOH B O 1 HETATM 6577 O O . HOH K 5 . ? 18.899 -37.533 -24.495 1.00 23.59 ? 810 HOH B O 1 HETATM 6578 O O . HOH K 5 . ? 12.259 -37.664 -45.822 1.00 20.41 ? 811 HOH B O 1 HETATM 6579 O O . HOH K 5 . ? -4.441 -38.502 -40.332 1.00 20.73 ? 812 HOH B O 1 HETATM 6580 O O . HOH K 5 . ? 0.000 -44.786 -20.585 0.33 36.90 ? 813 HOH B O 1 HETATM 6581 O O . HOH K 5 . ? -5.610 -27.688 22.026 1.00 41.48 ? 814 HOH B O 1 HETATM 6582 O O . HOH K 5 . ? 14.759 -35.527 -58.776 1.00 32.48 ? 815 HOH B O 1 HETATM 6583 O O . HOH K 5 . ? -2.581 -36.308 -31.730 1.00 31.14 ? 816 HOH B O 1 HETATM 6584 O O . HOH K 5 . ? -0.473 -29.787 35.055 1.00 38.27 ? 817 HOH B O 1 HETATM 6585 O O . HOH K 5 . ? 29.869 -47.444 -28.190 1.00 55.06 ? 818 HOH B O 1 HETATM 6586 O O . HOH K 5 . ? 14.084 -33.388 -58.262 1.00 23.17 ? 819 HOH B O 1 HETATM 6587 O O . HOH K 5 . ? -0.882 -37.000 -34.198 1.00 25.27 ? 820 HOH B O 1 HETATM 6588 O O . HOH K 5 . ? -7.643 -20.862 -57.561 1.00 30.23 ? 821 HOH B O 1 HETATM 6589 O O . HOH K 5 . ? -3.921 -40.358 -71.925 1.00 36.18 ? 822 HOH B O 1 HETATM 6590 O O . HOH K 5 . ? 10.028 -27.277 -49.744 1.00 24.05 ? 823 HOH B O 1 HETATM 6591 O O . HOH K 5 . ? -2.269 -32.948 39.881 1.00 48.47 ? 824 HOH B O 1 HETATM 6592 O O . HOH K 5 . ? 1.698 -21.613 -12.373 1.00 30.07 ? 825 HOH B O 1 HETATM 6593 O O . HOH K 5 . ? 5.255 -43.848 -20.884 1.00 35.30 ? 826 HOH B O 1 HETATM 6594 O O . HOH K 5 . ? 13.385 -19.024 -21.053 1.00 62.64 ? 827 HOH B O 1 HETATM 6595 O O . HOH K 5 . ? 14.289 -22.293 -16.152 1.00 31.58 ? 828 HOH B O 1 HETATM 6596 O O . HOH K 5 . ? 30.291 -46.617 -45.722 1.00 56.31 ? 829 HOH B O 1 HETATM 6597 O O . HOH K 5 . ? 22.878 -23.991 -55.419 1.00 51.85 ? 830 HOH B O 1 HETATM 6598 O O . HOH K 5 . ? 1.508 -43.666 -12.341 1.00 53.66 ? 831 HOH B O 1 HETATM 6599 O O . HOH K 5 . ? -7.542 -16.048 -46.620 1.00 66.45 ? 832 HOH B O 1 HETATM 6600 O O . HOH K 5 . ? -15.145 -34.732 13.131 1.00 32.94 ? 833 HOH B O 1 HETATM 6601 O O . HOH K 5 . ? -12.625 -26.511 -9.223 1.00 41.57 ? 834 HOH B O 1 HETATM 6602 O O . HOH K 5 . ? -6.635 -23.533 -69.696 1.00 63.05 ? 835 HOH B O 1 HETATM 6603 O O . HOH K 5 . ? 6.754 -21.221 -22.977 1.00 40.19 ? 836 HOH B O 1 HETATM 6604 O O . HOH K 5 . ? 7.145 -38.762 -44.051 1.00 29.06 ? 837 HOH B O 1 HETATM 6605 O O . HOH K 5 . ? 20.903 -40.259 -20.818 1.00 25.32 ? 838 HOH B O 1 HETATM 6606 O O . HOH K 5 . ? -6.976 -25.768 -19.663 1.00 38.14 ? 839 HOH B O 1 HETATM 6607 O O . HOH K 5 . ? 11.972 -23.699 -5.753 1.00 68.24 ? 840 HOH B O 1 HETATM 6608 O O . HOH K 5 . ? 27.129 -15.692 -40.496 1.00 54.52 ? 841 HOH B O 1 HETATM 6609 O O . HOH K 5 . ? 24.833 -17.722 -49.837 1.00 28.93 ? 842 HOH B O 1 HETATM 6610 O O . HOH K 5 . ? -11.589 -23.502 -64.515 1.00 51.57 ? 843 HOH B O 1 HETATM 6611 O O . HOH K 5 . ? 4.324 -24.730 -73.439 1.00 52.57 ? 844 HOH B O 1 HETATM 6612 O O . HOH K 5 . ? -6.229 -19.494 -57.700 1.00 38.14 ? 845 HOH B O 1 HETATM 6613 O O . HOH K 5 . ? 34.536 -42.809 -26.944 1.00 59.89 ? 846 HOH B O 1 HETATM 6614 O O . HOH K 5 . ? -0.878 -39.019 -24.186 1.00 40.66 ? 847 HOH B O 1 HETATM 6615 O O . HOH K 5 . ? 14.842 -21.195 -11.519 1.00 27.38 ? 848 HOH B O 1 HETATM 6616 O O . HOH K 5 . ? 12.408 -36.113 -52.682 1.00 45.84 ? 849 HOH B O 1 HETATM 6617 O O . HOH K 5 . ? 1.864 -39.810 -7.483 1.00 38.80 ? 850 HOH B O 1 HETATM 6618 O O . HOH K 5 . ? 2.168 -37.472 -6.627 1.00 56.84 ? 851 HOH B O 1 HETATM 6619 O O . HOH K 5 . ? -5.418 -37.815 18.607 1.00 59.54 ? 852 HOH B O 1 HETATM 6620 O O . HOH K 5 . ? 32.221 -46.135 -27.793 1.00 72.31 ? 853 HOH B O 1 HETATM 6621 O O . HOH K 5 . ? 27.612 -28.148 -32.335 1.00 67.74 ? 854 HOH B O 1 HETATM 6622 O O . HOH K 5 . ? 19.596 -35.732 -26.025 1.00 33.77 ? 855 HOH B O 1 HETATM 6623 O O . HOH K 5 . ? 9.327 -23.890 14.930 1.00 38.50 ? 856 HOH B O 1 HETATM 6624 O O . HOH K 5 . ? 13.762 -37.026 -53.466 1.00 17.34 ? 857 HOH B O 1 HETATM 6625 O O . HOH K 5 . ? 0.862 -14.929 -58.504 1.00 13.86 ? 858 HOH B O 1 HETATM 6626 O O . HOH K 5 . ? -12.299 -39.466 -27.019 1.00 16.75 ? 859 HOH B O 1 HETATM 6627 O O . HOH K 5 . ? -3.731 -38.459 -0.089 1.00 25.07 ? 860 HOH B O 1 HETATM 6628 O O . HOH K 5 . ? -7.638 -27.437 -32.870 1.00 34.54 ? 861 HOH B O 1 HETATM 6629 O O . HOH K 5 . ? -12.686 -31.141 22.564 1.00 25.32 ? 862 HOH B O 1 HETATM 6630 O O . HOH K 5 . ? 2.023 -15.033 -60.272 1.00 50.03 ? 863 HOH B O 1 HETATM 6631 O O . HOH K 5 . ? -8.275 -32.131 27.529 1.00 46.76 ? 864 HOH B O 1 HETATM 6632 O O . HOH K 5 . ? 26.628 -35.983 -53.949 1.00 57.51 ? 865 HOH B O 1 HETATM 6633 O O . HOH K 5 . ? 13.117 -23.573 -48.515 1.00 25.81 ? 866 HOH B O 1 HETATM 6634 O O . HOH K 5 . ? 32.577 -20.026 -54.451 1.00 62.19 ? 867 HOH B O 1 HETATM 6635 O O . HOH K 5 . ? 36.301 -35.015 -47.996 1.00 53.65 ? 868 HOH B O 1 HETATM 6636 O O . HOH K 5 . ? -1.724 -44.039 29.252 1.00 35.35 ? 869 HOH B O 1 HETATM 6637 O O . HOH K 5 . ? 8.384 -34.228 3.427 1.00 68.95 ? 870 HOH B O 1 HETATM 6638 O O . HOH K 5 . ? -15.509 -29.039 -48.008 1.00 51.55 ? 871 HOH B O 1 HETATM 6639 O O . HOH K 5 . ? 28.092 -32.818 -56.240 1.00 28.00 ? 872 HOH B O 1 HETATM 6640 O O . HOH K 5 . ? 20.286 -18.189 -56.000 1.00 50.16 ? 873 HOH B O 1 HETATM 6641 O O . HOH K 5 . ? -1.156 -40.890 -4.816 1.00 73.03 ? 874 HOH B O 1 HETATM 6642 O O . HOH K 5 . ? -8.865 -25.521 -3.029 1.00 53.02 ? 875 HOH B O 1 HETATM 6643 O O . HOH K 5 . ? -11.149 -42.485 33.949 1.00 24.54 ? 876 HOH B O 1 HETATM 6644 O O . HOH K 5 . ? 33.113 -25.811 -53.210 1.00 66.40 ? 877 HOH B O 1 HETATM 6645 O O . HOH K 5 . ? 37.549 -24.898 -46.831 1.00 64.73 ? 878 HOH B O 1 HETATM 6646 O O . HOH K 5 . ? 24.082 -21.176 -56.702 1.00 60.12 ? 879 HOH B O 1 HETATM 6647 O O . HOH K 5 . ? -15.479 -28.727 2.041 1.00 45.82 ? 880 HOH B O 1 HETATM 6648 O O . HOH K 5 . ? 18.261 -18.582 -57.641 1.00 56.57 ? 881 HOH B O 1 HETATM 6649 O O . HOH K 5 . ? -7.697 -24.781 0.180 1.00 65.59 ? 882 HOH B O 1 HETATM 6650 O O . HOH K 5 . ? 15.299 -35.455 -52.562 1.00 45.20 ? 883 HOH B O 1 HETATM 6651 O O . HOH K 5 . ? 34.303 -35.015 -45.339 1.00 65.52 ? 884 HOH B O 1 HETATM 6652 O O . HOH K 5 . ? -2.998 -41.344 -4.040 1.00 62.12 ? 885 HOH B O 1 HETATM 6653 O O . HOH K 5 . ? 16.966 -29.698 -27.008 1.00 62.04 ? 886 HOH B O 1 HETATM 6654 O O . HOH K 5 . ? 6.949 -33.008 3.977 1.00 54.75 ? 887 HOH B O 1 HETATM 6655 O O . HOH K 5 . ? -1.842 -43.827 32.187 1.00 68.99 ? 888 HOH B O 1 HETATM 6656 O O . HOH K 5 . ? 35.372 -33.518 -44.293 1.00 55.02 ? 889 HOH B O 1 HETATM 6657 O O . HOH K 5 . ? 36.554 -23.825 -45.077 1.00 70.96 ? 890 HOH B O 1 HETATM 6658 O O . HOH K 5 . ? 27.913 -34.655 -55.771 1.00 67.72 ? 891 HOH B O 1 HETATM 6659 O O . HOH K 5 . ? 37.998 -36.561 -47.452 1.00 65.92 ? 892 HOH B O 1 HETATM 6660 O O . HOH K 5 . ? -0.275 -21.948 -13.958 1.00 64.15 ? 893 HOH B O 1 HETATM 6661 O O . HOH K 5 . ? 21.240 -37.015 -26.881 1.00 68.03 ? 894 HOH B O 1 HETATM 6662 O O . HOH K 5 . ? 8.419 -19.350 -45.913 1.00 77.32 ? 895 HOH B O 1 HETATM 6663 O O . HOH K 5 . ? -3.879 -36.294 1.835 1.00 48.57 ? 896 HOH B O 1 HETATM 6664 O O . HOH K 5 . ? 16.259 -22.272 -17.970 1.00 56.93 ? 897 HOH B O 1 HETATM 6665 O O . HOH K 5 . ? 4.742 -17.281 -2.918 1.00 61.95 ? 898 HOH B O 1 HETATM 6666 O O . HOH K 5 . ? -3.322 -39.546 -38.229 1.00 28.83 ? 899 HOH B O 1 HETATM 6667 O O . HOH K 5 . ? 2.413 -39.642 29.390 1.00 28.83 ? 900 HOH B O 1 HETATM 6668 O O . HOH K 5 . ? -8.619 -33.589 33.365 1.00 47.28 ? 901 HOH B O 1 HETATM 6669 O O . HOH K 5 . ? 20.786 -43.057 -19.664 1.00 66.95 ? 902 HOH B O 1 HETATM 6670 O O . HOH K 5 . ? -0.808 -40.548 0.726 1.00 73.60 ? 903 HOH B O 1 HETATM 6671 O O . HOH K 5 . ? 8.836 -18.187 -22.478 1.00 65.16 ? 904 HOH B O 1 HETATM 6672 O O . HOH K 5 . ? 8.926 -42.810 -13.284 1.00 48.69 ? 905 HOH B O 1 HETATM 6673 O O . HOH K 5 . ? 24.788 -34.571 -24.730 1.00 55.45 ? 906 HOH B O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 GLY 1 -15 ? ? ? A . n A 1 2 HIS 2 -14 ? ? ? A . n A 1 3 HIS 3 -13 ? ? ? A . n A 1 4 HIS 4 -12 ? ? ? A . n A 1 5 HIS 5 -11 ? ? ? A . n A 1 6 HIS 6 -10 ? ? ? A . n A 1 7 HIS 7 -9 ? ? ? A . n A 1 8 HIS 8 -8 ? ? ? A . n A 1 9 HIS 9 -7 ? ? ? A . n A 1 10 GLY 10 -6 ? ? ? A . n A 1 11 SER 11 -5 ? ? ? A . n A 1 12 SER 12 -4 ? ? ? A . n A 1 13 THR 13 -3 ? ? ? A . n A 1 14 SER 14 -2 ? ? ? A . n A 1 15 ASN 15 -1 ? ? ? A . n A 1 16 GLY 16 0 ? ? ? A . n A 1 17 MET 17 1 ? ? ? A . n A 1 18 ARG 18 2 2 ARG ARG A . n A 1 19 CYS 19 3 3 CYS CYS A . n A 1 20 VAL 20 4 4 VAL VAL A . n A 1 21 GLY 21 5 5 GLY GLY A . n A 1 22 ILE 22 6 6 ILE ILE A . n A 1 23 GLY 23 7 7 GLY GLY A . n A 1 24 ASN 24 8 8 ASN ASN A . n A 1 25 ARG 25 9 9 ARG ARG A . n A 1 26 ASP 26 10 10 ASP ASP A . n A 1 27 PHE 27 11 11 PHE PHE A . n A 1 28 VAL 28 12 12 VAL VAL A . n A 1 29 GLU 29 13 13 GLU GLU A . n A 1 30 GLY 30 14 14 GLY GLY A . n A 1 31 LEU 31 15 15 LEU LEU A . n A 1 32 SER 32 16 16 SER SER A . n A 1 33 GLY 33 17 17 GLY GLY A . n A 1 34 ALA 34 18 18 ALA ALA A . n A 1 35 THR 35 19 19 THR THR A . n A 1 36 TRP 36 20 20 TRP TRP A . n A 1 37 VAL 37 21 21 VAL VAL A . n A 1 38 ASP 38 22 22 ASP ASP A . n A 1 39 VAL 39 23 23 VAL VAL A . n A 1 40 VAL 40 24 24 VAL VAL A . n A 1 41 LEU 41 25 25 LEU LEU A . n A 1 42 GLU 42 26 26 GLU GLU A . n A 1 43 HIS 43 27 27 HIS HIS A . n A 1 44 GLY 44 28 28 GLY GLY A . n A 1 45 SER 45 29 29 SER SER A . n A 1 46 CYS 46 30 30 CYS CYS A . n A 1 47 VAL 47 31 31 VAL VAL A . n A 1 48 THR 48 32 32 THR THR A . n A 1 49 THR 49 33 33 THR THR A . n A 1 50 MET 50 34 34 MET MET A . n A 1 51 ALA 51 35 35 ALA ALA A . n A 1 52 LYS 52 36 36 LYS LYS A . n A 1 53 ASP 53 37 37 ASP ASP A . n A 1 54 LYS 54 38 38 LYS LYS A . n A 1 55 PRO 55 39 39 PRO PRO A . n A 1 56 THR 56 40 40 THR THR A . n A 1 57 LEU 57 41 41 LEU LEU A . n A 1 58 ASP 58 42 42 ASP ASP A . n A 1 59 ILE 59 43 43 ILE ILE A . n A 1 60 GLU 60 44 44 GLU GLU A . n A 1 61 LEU 61 45 45 LEU LEU A . n A 1 62 LEU 62 46 46 LEU LEU A . n A 1 63 LYS 63 47 47 LYS LYS A . n A 1 64 THR 64 48 48 THR THR A . n A 1 65 GLU 65 49 49 GLU GLU A . n A 1 66 VAL 66 50 50 VAL VAL A . n A 1 67 THR 67 51 51 THR THR A . n A 1 68 ASN 68 52 52 ASN ASN A . n A 1 69 PRO 69 53 53 PRO PRO A . n A 1 70 ALA 70 54 54 ALA ALA A . n A 1 71 VAL 71 55 55 VAL VAL A . n A 1 72 LEU 72 56 56 LEU LEU A . n A 1 73 ARG 73 57 57 ARG ARG A . n A 1 74 LYS 74 58 58 LYS LYS A . n A 1 75 LEU 75 59 59 LEU LEU A . n A 1 76 CYS 76 60 60 CYS CYS A . n A 1 77 ILE 77 61 61 ILE ILE A . n A 1 78 GLU 78 62 62 GLU GLU A . n A 1 79 ALA 79 63 63 ALA ALA A . n A 1 80 LYS 80 64 64 LYS LYS A . n A 1 81 ILE 81 65 65 ILE ILE A . n A 1 82 SER 82 66 66 SER SER A . n A 1 83 ASN 83 67 67 ASN ASN A . n A 1 84 THR 84 68 68 THR THR A . n A 1 85 THR 85 69 69 THR THR A . n A 1 86 THR 86 70 70 THR THR A . n A 1 87 ASP 87 71 71 ASP ASP A . n A 1 88 SER 88 72 72 SER SER A . n A 1 89 ARG 89 73 73 ARG ARG A . n A 1 90 CYS 90 74 74 CYS CYS A . n A 1 91 PRO 91 75 75 PRO PRO A . n A 1 92 THR 92 76 76 THR THR A . n A 1 93 GLN 93 77 77 GLN GLN A . n A 1 94 GLY 94 78 78 GLY GLY A . n A 1 95 GLU 95 79 79 GLU GLU A . n A 1 96 ALA 96 80 80 ALA ALA A . n A 1 97 THR 97 81 81 THR THR A . n A 1 98 LEU 98 82 82 LEU LEU A . n A 1 99 VAL 99 83 83 VAL VAL A . n A 1 100 GLU 100 84 84 GLU GLU A . n A 1 101 GLU 101 85 85 GLU GLU A . n A 1 102 GLN 102 86 86 GLN GLN A . n A 1 103 ASP 103 87 87 ASP ASP A . n A 1 104 THR 104 88 88 THR THR A . n A 1 105 ASN 105 89 89 ASN ASN A . n A 1 106 PHE 106 90 90 PHE PHE A . n A 1 107 VAL 107 91 91 VAL VAL A . n A 1 108 CYS 108 92 92 CYS CYS A . n A 1 109 ARG 109 93 93 ARG ARG A . n A 1 110 ARG 110 94 94 ARG ARG A . n A 1 111 THR 111 95 95 THR THR A . n A 1 112 PHE 112 96 96 PHE PHE A . n A 1 113 VAL 113 97 97 VAL VAL A . n A 1 114 ASP 114 98 98 ASP ASP A . n A 1 115 ARG 115 99 99 ARG ARG A . n A 1 116 GLY 116 100 100 GLY GLY A . n A 1 117 HIS 117 101 101 HIS HIS A . n A 1 118 GLY 118 102 102 GLY GLY A . n A 1 119 ASN 119 103 103 ASN ASN A . n A 1 120 GLY 120 104 104 GLY GLY A . n A 1 121 CYS 121 105 105 CYS CYS A . n A 1 122 GLY 122 106 106 GLY GLY A . n A 1 123 LEU 123 107 107 LEU LEU A . n A 1 124 PHE 124 108 108 PHE PHE A . n A 1 125 GLY 125 109 109 GLY GLY A . n A 1 126 LYS 126 110 110 LYS LYS A . n A 1 127 GLY 127 111 111 GLY GLY A . n A 1 128 SER 128 112 112 SER SER A . n A 1 129 LEU 129 113 113 LEU LEU A . n A 1 130 ILE 130 114 114 ILE ILE A . n A 1 131 THR 131 115 115 THR THR A . n A 1 132 CYS 132 116 116 CYS CYS A . n A 1 133 ALA 133 117 117 ALA ALA A . n A 1 134 LYS 134 118 118 LYS LYS A . n A 1 135 PHE 135 119 119 PHE PHE A . n A 1 136 LYS 136 120 120 LYS LYS A . n A 1 137 CYS 137 121 121 CYS CYS A . n A 1 138 VAL 138 122 122 VAL VAL A . n A 1 139 THR 139 123 123 THR THR A . n A 1 140 LYS 140 124 124 LYS LYS A . n A 1 141 LEU 141 125 125 LEU LEU A . n A 1 142 GLU 142 126 126 GLU GLU A . n A 1 143 GLY 143 127 127 GLY GLY A . n A 1 144 LYS 144 128 128 LYS LYS A . n A 1 145 ILE 145 129 129 ILE ILE A . n A 1 146 VAL 146 130 130 VAL VAL A . n A 1 147 GLN 147 131 131 GLN GLN A . n A 1 148 TYR 148 132 132 TYR TYR A . n A 1 149 GLU 149 133 133 GLU GLU A . n A 1 150 ASN 150 134 134 ASN ASN A . n A 1 151 LEU 151 135 135 LEU LEU A . n A 1 152 LYS 152 136 136 LYS LYS A . n A 1 153 TYR 153 137 137 TYR TYR A . n A 1 154 SER 154 138 138 SER SER A . n A 1 155 VAL 155 139 139 VAL VAL A . n A 1 156 ILE 156 140 140 ILE ILE A . n A 1 157 VAL 157 141 141 VAL VAL A . n A 1 158 THR 158 142 142 THR THR A . n A 1 159 VAL 159 143 143 VAL VAL A . n A 1 160 HIS 160 144 144 HIS HIS A . n A 1 161 THR 161 145 145 THR THR A . n A 1 162 GLY 162 146 146 GLY GLY A . n A 1 163 ASP 163 147 ? ? ? A . n A 1 164 GLN 164 148 ? ? ? A . n A 1 165 HIS 165 149 ? ? ? A . n A 1 166 GLN 166 150 ? ? ? A . n A 1 167 VAL 167 151 ? ? ? A . n A 1 168 GLY 168 152 ? ? ? A . n A 1 169 ASN 169 153 ? ? ? A . n A 1 170 GLU 170 154 ? ? ? A . n A 1 171 THR 171 155 ? ? ? A . n A 1 172 THR 172 156 ? ? ? A . n A 1 173 GLU 173 157 ? ? ? A . n A 1 174 HIS 174 158 ? ? ? A . n A 1 175 GLY 175 159 159 GLY GLY A . n A 1 176 THR 176 160 160 THR THR A . n A 1 177 ILE 177 161 161 ILE ILE A . n A 1 178 ALA 178 162 162 ALA ALA A . n A 1 179 THR 179 163 163 THR THR A . n A 1 180 ILE 180 164 164 ILE ILE A . n A 1 181 THR 181 165 165 THR THR A . n A 1 182 PRO 182 166 166 PRO PRO A . n A 1 183 GLN 183 167 167 GLN GLN A . n A 1 184 ALA 184 168 168 ALA ALA A . n A 1 185 PRO 185 169 169 PRO PRO A . n A 1 186 THR 186 170 170 THR THR A . n A 1 187 SER 187 171 171 SER SER A . n A 1 188 GLU 188 172 172 GLU GLU A . n A 1 189 ILE 189 173 173 ILE ILE A . n A 1 190 GLN 190 174 174 GLN GLN A . n A 1 191 LEU 191 175 175 LEU LEU A . n A 1 192 THR 192 176 176 THR THR A . n A 1 193 ASP 193 177 177 ASP ASP A . n A 1 194 TYR 194 178 178 TYR TYR A . n A 1 195 GLY 195 179 179 GLY GLY A . n A 1 196 ALA 196 180 180 ALA ALA A . n A 1 197 LEU 197 181 181 LEU LEU A . n A 1 198 THR 198 182 182 THR THR A . n A 1 199 LEU 199 183 183 LEU LEU A . n A 1 200 ASP 200 184 184 ASP ASP A . n A 1 201 CYS 201 185 185 CYS CYS A . n A 1 202 SER 202 186 186 SER SER A . n A 1 203 PRO 203 187 187 PRO PRO A . n A 1 204 ARG 204 188 188 ARG ARG A . n A 1 205 THR 205 189 189 THR THR A . n A 1 206 GLY 206 190 190 GLY GLY A . n A 1 207 LEU 207 191 191 LEU LEU A . n A 1 208 ASP 208 192 192 ASP ASP A . n A 1 209 PHE 209 193 193 PHE PHE A . n A 1 210 ASN 210 194 194 ASN ASN A . n A 1 211 GLU 211 195 195 GLU GLU A . n A 1 212 MET 212 196 196 MET MET A . n A 1 213 VAL 213 197 197 VAL VAL A . n A 1 214 LEU 214 198 198 LEU LEU A . n A 1 215 LEU 215 199 199 LEU LEU A . n A 1 216 THR 216 200 200 THR THR A . n A 1 217 MET 217 201 201 MET MET A . n A 1 218 GLU 218 202 202 GLU GLU A . n A 1 219 LYS 219 203 203 LYS LYS A . n A 1 220 LYS 220 204 204 LYS LYS A . n A 1 221 SER 221 205 205 SER SER A . n A 1 222 TRP 222 206 206 TRP TRP A . n A 1 223 LEU 223 207 207 LEU LEU A . n A 1 224 VAL 224 208 208 VAL VAL A . n A 1 225 HIS 225 209 209 HIS HIS A . n A 1 226 LYS 226 210 210 LYS LYS A . n A 1 227 GLN 227 211 211 GLN GLN A . n A 1 228 TRP 228 212 212 TRP TRP A . n A 1 229 PHE 229 213 213 PHE PHE A . n A 1 230 LEU 230 214 214 LEU LEU A . n A 1 231 ASP 231 215 215 ASP ASP A . n A 1 232 LEU 232 216 216 LEU LEU A . n A 1 233 PRO 233 217 217 PRO PRO A . n A 1 234 LEU 234 218 218 LEU LEU A . n A 1 235 PRO 235 219 219 PRO PRO A . n A 1 236 TRP 236 220 220 TRP TRP A . n A 1 237 THR 237 221 221 THR THR A . n A 1 238 SER 238 222 222 SER SER A . n A 1 239 GLY 239 223 223 GLY GLY A . n A 1 240 ALA 240 224 224 ALA ALA A . n A 1 241 SER 241 225 225 SER SER A . n A 1 242 THR 242 226 226 THR THR A . n A 1 243 SER 243 227 227 SER SER A . n A 1 244 GLN 244 228 228 GLN GLN A . n A 1 245 GLU 245 229 229 GLU GLU A . n A 1 246 THR 246 230 230 THR THR A . n A 1 247 TRP 247 231 231 TRP TRP A . n A 1 248 ASN 248 232 232 ASN ASN A . n A 1 249 ARG 249 233 233 ARG ARG A . n A 1 250 GLN 250 234 234 GLN GLN A . n A 1 251 ASP 251 235 235 ASP ASP A . n A 1 252 LEU 252 236 236 LEU LEU A . n A 1 253 LEU 253 237 237 LEU LEU A . n A 1 254 VAL 254 238 238 VAL VAL A . n A 1 255 THR 255 239 239 THR THR A . n A 1 256 PHE 256 240 240 PHE PHE A . n A 1 257 LYS 257 241 241 LYS LYS A . n A 1 258 THR 258 242 242 THR THR A . n A 1 259 ALA 259 243 243 ALA ALA A . n A 1 260 HIS 260 244 244 HIS HIS A . n A 1 261 ALA 261 245 245 ALA ALA A . n A 1 262 LYS 262 246 246 LYS LYS A . n A 1 263 LYS 263 247 247 LYS LYS A . n A 1 264 GLN 264 248 248 GLN GLN A . n A 1 265 GLU 265 249 249 GLU GLU A . n A 1 266 VAL 266 250 250 VAL VAL A . n A 1 267 VAL 267 251 251 VAL VAL A . n A 1 268 VAL 268 252 252 VAL VAL A . n A 1 269 LEU 269 253 253 LEU LEU A . n A 1 270 GLY 270 254 254 GLY GLY A . n A 1 271 SER 271 255 255 SER SER A . n A 1 272 GLN 272 256 256 GLN GLN A . n A 1 273 GLU 273 257 257 GLU GLU A . n A 1 274 GLY 274 258 258 GLY GLY A . n A 1 275 ALA 275 259 259 ALA ALA A . n A 1 276 MET 276 260 260 MET MET A . n A 1 277 HIS 277 261 261 HIS HIS A . n A 1 278 THR 278 262 262 THR THR A . n A 1 279 ALA 279 263 263 ALA ALA A . n A 1 280 LEU 280 264 264 LEU LEU A . n A 1 281 THR 281 265 265 THR THR A . n A 1 282 GLY 282 266 266 GLY GLY A . n A 1 283 ALA 283 267 267 ALA ALA A . n A 1 284 THR 284 268 268 THR THR A . n A 1 285 GLU 285 269 269 GLU GLU A . n A 1 286 ILE 286 270 270 ILE ILE A . n A 1 287 GLN 287 271 271 GLN GLN A . n A 1 288 THR 288 272 272 THR THR A . n A 1 289 SER 289 273 273 SER SER A . n A 1 290 GLY 290 274 274 GLY GLY A . n A 1 291 THR 291 275 275 THR THR A . n A 1 292 THR 292 276 276 THR THR A . n A 1 293 THR 293 277 277 THR THR A . n A 1 294 ILE 294 278 278 ILE ILE A . n A 1 295 PHE 295 279 279 PHE PHE A . n A 1 296 ALA 296 280 280 ALA ALA A . n A 1 297 GLY 297 281 281 GLY GLY A . n A 1 298 HIS 298 282 282 HIS HIS A . n A 1 299 LEU 299 283 283 LEU LEU A . n A 1 300 LYS 300 284 284 LYS LYS A . n A 1 301 CYS 301 285 285 CYS CYS A . n A 1 302 ARG 302 286 286 ARG ARG A . n A 1 303 LEU 303 287 287 LEU LEU A . n A 1 304 LYS 304 288 288 LYS LYS A . n A 1 305 MET 305 289 289 MET MET A . n A 1 306 ASP 306 290 290 ASP ASP A . n A 1 307 LYS 307 291 291 LYS LYS A . n A 1 308 LEU 308 292 292 LEU LEU A . n A 1 309 THR 309 293 293 THR THR A . n A 1 310 LEU 310 294 294 LEU LEU A . n A 1 311 LYS 311 295 295 LYS LYS A . n A 1 312 GLY 312 296 296 GLY GLY A . n A 1 313 MET 313 297 297 MET MET A . n A 1 314 SER 314 298 298 SER SER A . n A 1 315 TYR 315 299 299 TYR TYR A . n A 1 316 VAL 316 300 300 VAL VAL A . n A 1 317 MET 317 301 301 MET MET A . n A 1 318 CYS 318 302 302 CYS CYS A . n A 1 319 THR 319 303 303 THR THR A . n A 1 320 GLY 320 304 304 GLY GLY A . n A 1 321 SER 321 305 305 SER SER A . n A 1 322 PHE 322 306 306 PHE PHE A . n A 1 323 LYS 323 307 307 LYS LYS A . n A 1 324 LEU 324 308 308 LEU LEU A . n A 1 325 GLU 325 309 309 GLU GLU A . n A 1 326 LYS 326 310 310 LYS LYS A . n A 1 327 GLU 327 311 311 GLU GLU A . n A 1 328 VAL 328 312 312 VAL VAL A . n A 1 329 ALA 329 313 313 ALA ALA A . n A 1 330 GLU 330 314 314 GLU GLU A . n A 1 331 THR 331 315 315 THR THR A . n A 1 332 GLN 332 316 316 GLN GLN A . n A 1 333 HIS 333 317 317 HIS HIS A . n A 1 334 GLY 334 318 318 GLY GLY A . n A 1 335 THR 335 319 319 THR THR A . n A 1 336 VAL 336 320 320 VAL VAL A . n A 1 337 LEU 337 321 321 LEU LEU A . n A 1 338 VAL 338 322 322 VAL VAL A . n A 1 339 GLN 339 323 323 GLN GLN A . n A 1 340 VAL 340 324 324 VAL VAL A . n A 1 341 LYS 341 325 325 LYS LYS A . n A 1 342 TYR 342 326 326 TYR TYR A . n A 1 343 GLU 343 327 327 GLU GLU A . n A 1 344 GLY 344 328 328 GLY GLY A . n A 1 345 THR 345 329 329 THR THR A . n A 1 346 ASP 346 330 330 ASP ASP A . n A 1 347 ALA 347 331 331 ALA ALA A . n A 1 348 PRO 348 332 332 PRO PRO A . n A 1 349 CYS 349 333 333 CYS CYS A . n A 1 350 LYS 350 334 334 LYS LYS A . n A 1 351 ILE 351 335 335 ILE ILE A . n A 1 352 PRO 352 336 336 PRO PRO A . n A 1 353 PHE 353 337 337 PHE PHE A . n A 1 354 SER 354 338 338 SER SER A . n A 1 355 SER 355 339 339 SER SER A . n A 1 356 GLN 356 340 340 GLN GLN A . n A 1 357 ASP 357 341 341 ASP ASP A . n A 1 358 GLU 358 342 342 GLU GLU A . n A 1 359 LYS 359 343 343 LYS LYS A . n A 1 360 GLY 360 344 344 GLY GLY A . n A 1 361 VAL 361 345 345 VAL VAL A . n A 1 362 THR 362 346 346 THR THR A . n A 1 363 GLN 363 347 347 GLN GLN A . n A 1 364 ASN 364 348 348 ASN ASN A . n A 1 365 GLY 365 349 349 GLY GLY A . n A 1 366 ARG 366 350 350 ARG ARG A . n A 1 367 LEU 367 351 351 LEU LEU A . n A 1 368 ILE 368 352 352 ILE ILE A . n A 1 369 THR 369 353 353 THR THR A . n A 1 370 ALA 370 354 354 ALA ALA A . n A 1 371 ASN 371 355 355 ASN ASN A . n A 1 372 PRO 372 356 356 PRO PRO A . n A 1 373 ILE 373 357 357 ILE ILE A . n A 1 374 VAL 374 358 358 VAL VAL A . n A 1 375 THR 375 359 359 THR THR A . n A 1 376 ASP 376 360 360 ASP ASP A . n A 1 377 LYS 377 361 361 LYS LYS A . n A 1 378 GLU 378 362 362 GLU GLU A . n A 1 379 LYS 379 363 363 LYS LYS A . n A 1 380 PRO 380 364 364 PRO PRO A . n A 1 381 VAL 381 365 365 VAL VAL A . n A 1 382 ASN 382 366 366 ASN ASN A . n A 1 383 ILE 383 367 367 ILE ILE A . n A 1 384 GLU 384 368 368 GLU GLU A . n A 1 385 ALA 385 369 369 ALA ALA A . n A 1 386 GLU 386 370 370 GLU GLU A . n A 1 387 PRO 387 371 371 PRO PRO A . n A 1 388 PRO 388 372 372 PRO PRO A . n A 1 389 PHE 389 373 373 PHE PHE A . n A 1 390 GLY 390 374 374 GLY GLY A . n A 1 391 GLU 391 375 375 GLU GLU A . n A 1 392 SER 392 376 376 SER SER A . n A 1 393 TYR 393 377 377 TYR TYR A . n A 1 394 ILE 394 378 378 ILE ILE A . n A 1 395 VAL 395 379 379 VAL VAL A . n A 1 396 VAL 396 380 380 VAL VAL A . n A 1 397 GLY 397 381 381 GLY GLY A . n A 1 398 ALA 398 382 382 ALA ALA A . n A 1 399 GLY 399 383 383 GLY GLY A . n A 1 400 GLU 400 384 384 GLU GLU A . n A 1 401 LYS 401 385 385 LYS LYS A . n A 1 402 ALA 402 386 386 ALA ALA A . n A 1 403 LEU 403 387 387 LEU LEU A . n A 1 404 LYS 404 388 388 LYS LYS A . n A 1 405 LEU 405 389 389 LEU LEU A . n A 1 406 SER 406 390 390 SER SER A . n A 1 407 TRP 407 391 391 TRP TRP A . n A 1 408 PHE 408 392 392 PHE PHE A . n A 1 409 LYS 409 393 393 LYS LYS A . n A 1 410 LYS 410 394 394 LYS LYS A . n A 1 411 GLY 411 395 395 GLY GLY A . n A 1 412 SER 412 396 396 SER SER A . n A 1 413 SER 413 397 397 SER SER A . n A 1 414 ILE 414 398 398 ILE ILE A . n A 1 415 GLY 415 399 399 GLY GLY A . n A 1 416 LYS 416 400 400 LYS LYS A . n A 1 417 MET 417 401 401 MET MET A . n A 1 418 PHE 418 402 402 PHE PHE A . n A 1 419 GLU 419 403 403 GLU GLU A . n A 1 420 ALA 420 404 ? ? ? A . n A 1 421 THR 421 405 ? ? ? A . n A 1 422 ALA 422 406 ? ? ? A . n A 1 423 ARG 423 407 ? ? ? A . n A 1 424 GLY 424 408 ? ? ? A . n A 1 425 ALA 425 409 ? ? ? A . n A 1 426 ARG 426 410 ? ? ? A . n A 1 427 ARG 427 411 ? ? ? A . n B 1 1 GLY 1 -15 ? ? ? B . n B 1 2 HIS 2 -14 ? ? ? B . n B 1 3 HIS 3 -13 ? ? ? B . n B 1 4 HIS 4 -12 ? ? ? B . n B 1 5 HIS 5 -11 ? ? ? B . n B 1 6 HIS 6 -10 ? ? ? B . n B 1 7 HIS 7 -9 ? ? ? B . n B 1 8 HIS 8 -8 ? ? ? B . n B 1 9 HIS 9 -7 ? ? ? B . n B 1 10 GLY 10 -6 ? ? ? B . n B 1 11 SER 11 -5 ? ? ? B . n B 1 12 SER 12 -4 ? ? ? B . n B 1 13 THR 13 -3 ? ? ? B . n B 1 14 SER 14 -2 ? ? ? B . n B 1 15 ASN 15 -1 ? ? ? B . n B 1 16 GLY 16 0 ? ? ? B . n B 1 17 MET 17 1 ? ? ? B . n B 1 18 ARG 18 2 2 ARG ARG B . n B 1 19 CYS 19 3 3 CYS CYS B . n B 1 20 VAL 20 4 4 VAL VAL B . n B 1 21 GLY 21 5 5 GLY GLY B . n B 1 22 ILE 22 6 6 ILE ILE B . n B 1 23 GLY 23 7 7 GLY GLY B . n B 1 24 ASN 24 8 8 ASN ASN B . n B 1 25 ARG 25 9 9 ARG ARG B . n B 1 26 ASP 26 10 10 ASP ASP B . n B 1 27 PHE 27 11 11 PHE PHE B . n B 1 28 VAL 28 12 12 VAL VAL B . n B 1 29 GLU 29 13 13 GLU GLU B . n B 1 30 GLY 30 14 14 GLY GLY B . n B 1 31 LEU 31 15 15 LEU LEU B . n B 1 32 SER 32 16 16 SER SER B . n B 1 33 GLY 33 17 17 GLY GLY B . n B 1 34 ALA 34 18 18 ALA ALA B . n B 1 35 THR 35 19 19 THR THR B . n B 1 36 TRP 36 20 20 TRP TRP B . n B 1 37 VAL 37 21 21 VAL VAL B . n B 1 38 ASP 38 22 22 ASP ASP B . n B 1 39 VAL 39 23 23 VAL VAL B . n B 1 40 VAL 40 24 24 VAL VAL B . n B 1 41 LEU 41 25 25 LEU LEU B . n B 1 42 GLU 42 26 26 GLU GLU B . n B 1 43 HIS 43 27 27 HIS HIS B . n B 1 44 GLY 44 28 28 GLY GLY B . n B 1 45 SER 45 29 29 SER SER B . n B 1 46 CYS 46 30 30 CYS CYS B . n B 1 47 VAL 47 31 31 VAL VAL B . n B 1 48 THR 48 32 32 THR THR B . n B 1 49 THR 49 33 33 THR THR B . n B 1 50 MET 50 34 34 MET MET B . n B 1 51 ALA 51 35 35 ALA ALA B . n B 1 52 LYS 52 36 36 LYS LYS B . n B 1 53 ASP 53 37 37 ASP ASP B . n B 1 54 LYS 54 38 38 LYS LYS B . n B 1 55 PRO 55 39 39 PRO PRO B . n B 1 56 THR 56 40 40 THR THR B . n B 1 57 LEU 57 41 41 LEU LEU B . n B 1 58 ASP 58 42 42 ASP ASP B . n B 1 59 ILE 59 43 43 ILE ILE B . n B 1 60 GLU 60 44 44 GLU GLU B . n B 1 61 LEU 61 45 45 LEU LEU B . n B 1 62 LEU 62 46 46 LEU LEU B . n B 1 63 LYS 63 47 47 LYS LYS B . n B 1 64 THR 64 48 48 THR THR B . n B 1 65 GLU 65 49 49 GLU GLU B . n B 1 66 VAL 66 50 50 VAL VAL B . n B 1 67 THR 67 51 51 THR THR B . n B 1 68 ASN 68 52 52 ASN ASN B . n B 1 69 PRO 69 53 53 PRO PRO B . n B 1 70 ALA 70 54 54 ALA ALA B . n B 1 71 VAL 71 55 55 VAL VAL B . n B 1 72 LEU 72 56 56 LEU LEU B . n B 1 73 ARG 73 57 57 ARG ARG B . n B 1 74 LYS 74 58 58 LYS LYS B . n B 1 75 LEU 75 59 59 LEU LEU B . n B 1 76 CYS 76 60 60 CYS CYS B . n B 1 77 ILE 77 61 61 ILE ILE B . n B 1 78 GLU 78 62 62 GLU GLU B . n B 1 79 ALA 79 63 63 ALA ALA B . n B 1 80 LYS 80 64 64 LYS LYS B . n B 1 81 ILE 81 65 65 ILE ILE B . n B 1 82 SER 82 66 66 SER SER B . n B 1 83 ASN 83 67 67 ASN ASN B . n B 1 84 THR 84 68 68 THR THR B . n B 1 85 THR 85 69 69 THR THR B . n B 1 86 THR 86 70 70 THR THR B . n B 1 87 ASP 87 71 71 ASP ASP B . n B 1 88 SER 88 72 72 SER SER B . n B 1 89 ARG 89 73 73 ARG ARG B . n B 1 90 CYS 90 74 74 CYS CYS B . n B 1 91 PRO 91 75 75 PRO PRO B . n B 1 92 THR 92 76 76 THR THR B . n B 1 93 GLN 93 77 77 GLN GLN B . n B 1 94 GLY 94 78 78 GLY GLY B . n B 1 95 GLU 95 79 79 GLU GLU B . n B 1 96 ALA 96 80 80 ALA ALA B . n B 1 97 THR 97 81 81 THR THR B . n B 1 98 LEU 98 82 82 LEU LEU B . n B 1 99 VAL 99 83 83 VAL VAL B . n B 1 100 GLU 100 84 84 GLU ALA B . n B 1 101 GLU 101 85 85 GLU GLU B . n B 1 102 GLN 102 86 86 GLN GLN B . n B 1 103 ASP 103 87 87 ASP ASP B . n B 1 104 THR 104 88 88 THR THR B . n B 1 105 ASN 105 89 89 ASN ASN B . n B 1 106 PHE 106 90 90 PHE PHE B . n B 1 107 VAL 107 91 91 VAL VAL B . n B 1 108 CYS 108 92 92 CYS CYS B . n B 1 109 ARG 109 93 93 ARG ARG B . n B 1 110 ARG 110 94 94 ARG ARG B . n B 1 111 THR 111 95 95 THR THR B . n B 1 112 PHE 112 96 96 PHE PHE B . n B 1 113 VAL 113 97 97 VAL VAL B . n B 1 114 ASP 114 98 98 ASP ASP B . n B 1 115 ARG 115 99 99 ARG ARG B . n B 1 116 GLY 116 100 100 GLY GLY B . n B 1 117 HIS 117 101 ? ? ? B . n B 1 118 GLY 118 102 102 GLY GLY B . n B 1 119 ASN 119 103 103 ASN ASN B . n B 1 120 GLY 120 104 104 GLY GLY B . n B 1 121 CYS 121 105 105 CYS CYS B . n B 1 122 GLY 122 106 106 GLY GLY B . n B 1 123 LEU 123 107 107 LEU LEU B . n B 1 124 PHE 124 108 108 PHE PHE B . n B 1 125 GLY 125 109 109 GLY GLY B . n B 1 126 LYS 126 110 110 LYS LYS B . n B 1 127 GLY 127 111 111 GLY GLY B . n B 1 128 SER 128 112 112 SER SER B . n B 1 129 LEU 129 113 113 LEU LEU B . n B 1 130 ILE 130 114 114 ILE ILE B . n B 1 131 THR 131 115 115 THR THR B . n B 1 132 CYS 132 116 116 CYS CYS B . n B 1 133 ALA 133 117 117 ALA ALA B . n B 1 134 LYS 134 118 118 LYS LYS B . n B 1 135 PHE 135 119 119 PHE PHE B . n B 1 136 LYS 136 120 120 LYS LYS B . n B 1 137 CYS 137 121 121 CYS CYS B . n B 1 138 VAL 138 122 122 VAL VAL B . n B 1 139 THR 139 123 123 THR THR B . n B 1 140 LYS 140 124 124 LYS LYS B . n B 1 141 LEU 141 125 125 LEU LEU B . n B 1 142 GLU 142 126 126 GLU GLU B . n B 1 143 GLY 143 127 127 GLY GLY B . n B 1 144 LYS 144 128 128 LYS LYS B . n B 1 145 ILE 145 129 129 ILE ILE B . n B 1 146 VAL 146 130 130 VAL VAL B . n B 1 147 GLN 147 131 131 GLN GLN B . n B 1 148 TYR 148 132 132 TYR TYR B . n B 1 149 GLU 149 133 133 GLU GLU B . n B 1 150 ASN 150 134 134 ASN ASN B . n B 1 151 LEU 151 135 135 LEU LEU B . n B 1 152 LYS 152 136 136 LYS LYS B . n B 1 153 TYR 153 137 137 TYR TYR B . n B 1 154 SER 154 138 138 SER SER B . n B 1 155 VAL 155 139 139 VAL VAL B . n B 1 156 ILE 156 140 140 ILE ILE B . n B 1 157 VAL 157 141 141 VAL VAL B . n B 1 158 THR 158 142 142 THR THR B . n B 1 159 VAL 159 143 143 VAL VAL B . n B 1 160 HIS 160 144 144 HIS HIS B . n B 1 161 THR 161 145 145 THR THR B . n B 1 162 GLY 162 146 ? ? ? B . n B 1 163 ASP 163 147 ? ? ? B . n B 1 164 GLN 164 148 ? ? ? B . n B 1 165 HIS 165 149 ? ? ? B . n B 1 166 GLN 166 150 ? ? ? B . n B 1 167 VAL 167 151 ? ? ? B . n B 1 168 GLY 168 152 ? ? ? B . n B 1 169 ASN 169 153 ? ? ? B . n B 1 170 GLU 170 154 ? ? ? B . n B 1 171 THR 171 155 ? ? ? B . n B 1 172 THR 172 156 ? ? ? B . n B 1 173 GLU 173 157 ? ? ? B . n B 1 174 HIS 174 158 158 HIS HIS B . n B 1 175 GLY 175 159 159 GLY GLY B . n B 1 176 THR 176 160 160 THR THR B . n B 1 177 ILE 177 161 161 ILE ILE B . n B 1 178 ALA 178 162 162 ALA ALA B . n B 1 179 THR 179 163 163 THR THR B . n B 1 180 ILE 180 164 164 ILE ILE B . n B 1 181 THR 181 165 165 THR THR B . n B 1 182 PRO 182 166 166 PRO PRO B . n B 1 183 GLN 183 167 167 GLN GLN B . n B 1 184 ALA 184 168 168 ALA ALA B . n B 1 185 PRO 185 169 169 PRO PRO B . n B 1 186 THR 186 170 170 THR THR B . n B 1 187 SER 187 171 171 SER SER B . n B 1 188 GLU 188 172 172 GLU GLU B . n B 1 189 ILE 189 173 173 ILE ILE B . n B 1 190 GLN 190 174 174 GLN GLN B . n B 1 191 LEU 191 175 175 LEU LEU B . n B 1 192 THR 192 176 176 THR THR B . n B 1 193 ASP 193 177 177 ASP ASP B . n B 1 194 TYR 194 178 178 TYR TYR B . n B 1 195 GLY 195 179 179 GLY GLY B . n B 1 196 ALA 196 180 180 ALA ALA B . n B 1 197 LEU 197 181 181 LEU LEU B . n B 1 198 THR 198 182 182 THR THR B . n B 1 199 LEU 199 183 183 LEU LEU B . n B 1 200 ASP 200 184 184 ASP ASP B . n B 1 201 CYS 201 185 185 CYS CYS B . n B 1 202 SER 202 186 186 SER SER B . n B 1 203 PRO 203 187 187 PRO PRO B . n B 1 204 ARG 204 188 188 ARG ARG B . n B 1 205 THR 205 189 189 THR THR B . n B 1 206 GLY 206 190 190 GLY GLY B . n B 1 207 LEU 207 191 191 LEU LEU B . n B 1 208 ASP 208 192 192 ASP ASP B . n B 1 209 PHE 209 193 193 PHE PHE B . n B 1 210 ASN 210 194 194 ASN ASN B . n B 1 211 GLU 211 195 195 GLU GLU B . n B 1 212 MET 212 196 196 MET MET B . n B 1 213 VAL 213 197 197 VAL VAL B . n B 1 214 LEU 214 198 198 LEU LEU B . n B 1 215 LEU 215 199 199 LEU LEU B . n B 1 216 THR 216 200 200 THR THR B . n B 1 217 MET 217 201 201 MET MET B . n B 1 218 GLU 218 202 202 GLU GLU B . n B 1 219 LYS 219 203 203 LYS LYS B . n B 1 220 LYS 220 204 204 LYS LYS B . n B 1 221 SER 221 205 205 SER SER B . n B 1 222 TRP 222 206 206 TRP TRP B . n B 1 223 LEU 223 207 207 LEU LEU B . n B 1 224 VAL 224 208 208 VAL VAL B . n B 1 225 HIS 225 209 209 HIS HIS B . n B 1 226 LYS 226 210 210 LYS LYS B . n B 1 227 GLN 227 211 211 GLN GLN B . n B 1 228 TRP 228 212 212 TRP TRP B . n B 1 229 PHE 229 213 213 PHE PHE B . n B 1 230 LEU 230 214 214 LEU LEU B . n B 1 231 ASP 231 215 215 ASP ASP B . n B 1 232 LEU 232 216 216 LEU LEU B . n B 1 233 PRO 233 217 217 PRO PRO B . n B 1 234 LEU 234 218 218 LEU LEU B . n B 1 235 PRO 235 219 219 PRO PRO B . n B 1 236 TRP 236 220 220 TRP TRP B . n B 1 237 THR 237 221 221 THR THR B . n B 1 238 SER 238 222 222 SER SER B . n B 1 239 GLY 239 223 223 GLY GLY B . n B 1 240 ALA 240 224 224 ALA ALA B . n B 1 241 SER 241 225 225 SER SER B . n B 1 242 THR 242 226 226 THR THR B . n B 1 243 SER 243 227 227 SER SER B . n B 1 244 GLN 244 228 228 GLN GLN B . n B 1 245 GLU 245 229 229 GLU GLU B . n B 1 246 THR 246 230 230 THR THR B . n B 1 247 TRP 247 231 231 TRP TRP B . n B 1 248 ASN 248 232 232 ASN ASN B . n B 1 249 ARG 249 233 233 ARG ARG B . n B 1 250 GLN 250 234 234 GLN GLN B . n B 1 251 ASP 251 235 235 ASP ASP B . n B 1 252 LEU 252 236 236 LEU LEU B . n B 1 253 LEU 253 237 237 LEU LEU B . n B 1 254 VAL 254 238 238 VAL VAL B . n B 1 255 THR 255 239 239 THR THR B . n B 1 256 PHE 256 240 240 PHE PHE B . n B 1 257 LYS 257 241 241 LYS LYS B . n B 1 258 THR 258 242 242 THR THR B . n B 1 259 ALA 259 243 243 ALA ALA B . n B 1 260 HIS 260 244 244 HIS ALA B . n B 1 261 ALA 261 245 245 ALA ALA B . n B 1 262 LYS 262 246 246 LYS ALA B . n B 1 263 LYS 263 247 247 LYS ALA B . n B 1 264 GLN 264 248 248 GLN GLN B . n B 1 265 GLU 265 249 249 GLU GLU B . n B 1 266 VAL 266 250 250 VAL VAL B . n B 1 267 VAL 267 251 251 VAL VAL B . n B 1 268 VAL 268 252 252 VAL VAL B . n B 1 269 LEU 269 253 253 LEU LEU B . n B 1 270 GLY 270 254 254 GLY GLY B . n B 1 271 SER 271 255 255 SER SER B . n B 1 272 GLN 272 256 256 GLN GLN B . n B 1 273 GLU 273 257 257 GLU GLU B . n B 1 274 GLY 274 258 258 GLY GLY B . n B 1 275 ALA 275 259 259 ALA ALA B . n B 1 276 MET 276 260 260 MET MET B . n B 1 277 HIS 277 261 261 HIS HIS B . n B 1 278 THR 278 262 262 THR THR B . n B 1 279 ALA 279 263 263 ALA ALA B . n B 1 280 LEU 280 264 264 LEU LEU B . n B 1 281 THR 281 265 265 THR THR B . n B 1 282 GLY 282 266 266 GLY GLY B . n B 1 283 ALA 283 267 267 ALA ALA B . n B 1 284 THR 284 268 268 THR THR B . n B 1 285 GLU 285 269 269 GLU GLU B . n B 1 286 ILE 286 270 270 ILE ILE B . n B 1 287 GLN 287 271 271 GLN GLN B . n B 1 288 THR 288 272 272 THR THR B . n B 1 289 SER 289 273 273 SER SER B . n B 1 290 GLY 290 274 274 GLY GLY B . n B 1 291 THR 291 275 275 THR THR B . n B 1 292 THR 292 276 276 THR THR B . n B 1 293 THR 293 277 277 THR THR B . n B 1 294 ILE 294 278 278 ILE ILE B . n B 1 295 PHE 295 279 279 PHE PHE B . n B 1 296 ALA 296 280 280 ALA ALA B . n B 1 297 GLY 297 281 281 GLY GLY B . n B 1 298 HIS 298 282 282 HIS HIS B . n B 1 299 LEU 299 283 283 LEU LEU B . n B 1 300 LYS 300 284 284 LYS LYS B . n B 1 301 CYS 301 285 285 CYS CYS B . n B 1 302 ARG 302 286 286 ARG ARG B . n B 1 303 LEU 303 287 287 LEU LEU B . n B 1 304 LYS 304 288 288 LYS LYS B . n B 1 305 MET 305 289 289 MET MET B . n B 1 306 ASP 306 290 290 ASP ASP B . n B 1 307 LYS 307 291 291 LYS LYS B . n B 1 308 LEU 308 292 292 LEU LEU B . n B 1 309 THR 309 293 293 THR THR B . n B 1 310 LEU 310 294 294 LEU LEU B . n B 1 311 LYS 311 295 295 LYS LYS B . n B 1 312 GLY 312 296 296 GLY GLY B . n B 1 313 MET 313 297 297 MET MET B . n B 1 314 SER 314 298 298 SER SER B . n B 1 315 TYR 315 299 299 TYR TYR B . n B 1 316 VAL 316 300 300 VAL VAL B . n B 1 317 MET 317 301 301 MET MET B . n B 1 318 CYS 318 302 302 CYS CYS B . n B 1 319 THR 319 303 303 THR THR B . n B 1 320 GLY 320 304 304 GLY GLY B . n B 1 321 SER 321 305 305 SER SER B . n B 1 322 PHE 322 306 306 PHE PHE B . n B 1 323 LYS 323 307 307 LYS LYS B . n B 1 324 LEU 324 308 308 LEU LEU B . n B 1 325 GLU 325 309 309 GLU GLU B . n B 1 326 LYS 326 310 310 LYS LYS B . n B 1 327 GLU 327 311 311 GLU GLU B . n B 1 328 VAL 328 312 312 VAL VAL B . n B 1 329 ALA 329 313 313 ALA ALA B . n B 1 330 GLU 330 314 314 GLU GLU B . n B 1 331 THR 331 315 315 THR THR B . n B 1 332 GLN 332 316 316 GLN GLN B . n B 1 333 HIS 333 317 317 HIS HIS B . n B 1 334 GLY 334 318 318 GLY GLY B . n B 1 335 THR 335 319 319 THR THR B . n B 1 336 VAL 336 320 320 VAL VAL B . n B 1 337 LEU 337 321 321 LEU LEU B . n B 1 338 VAL 338 322 322 VAL VAL B . n B 1 339 GLN 339 323 323 GLN GLN B . n B 1 340 VAL 340 324 324 VAL VAL B . n B 1 341 LYS 341 325 325 LYS LYS B . n B 1 342 TYR 342 326 326 TYR TYR B . n B 1 343 GLU 343 327 327 GLU GLU B . n B 1 344 GLY 344 328 328 GLY GLY B . n B 1 345 THR 345 329 329 THR THR B . n B 1 346 ASP 346 330 330 ASP ASP B . n B 1 347 ALA 347 331 331 ALA ALA B . n B 1 348 PRO 348 332 332 PRO PRO B . n B 1 349 CYS 349 333 333 CYS CYS B . n B 1 350 LYS 350 334 334 LYS LYS B . n B 1 351 ILE 351 335 335 ILE ILE B . n B 1 352 PRO 352 336 336 PRO PRO B . n B 1 353 PHE 353 337 337 PHE PHE B . n B 1 354 SER 354 338 338 SER SER B . n B 1 355 SER 355 339 339 SER SER B . n B 1 356 GLN 356 340 340 GLN GLN B . n B 1 357 ASP 357 341 341 ASP ASP B . n B 1 358 GLU 358 342 342 GLU GLU B . n B 1 359 LYS 359 343 343 LYS ALA B . n B 1 360 GLY 360 344 344 GLY GLY B . n B 1 361 VAL 361 345 345 VAL VAL B . n B 1 362 THR 362 346 346 THR THR B . n B 1 363 GLN 363 347 347 GLN GLN B . n B 1 364 ASN 364 348 348 ASN ASN B . n B 1 365 GLY 365 349 349 GLY GLY B . n B 1 366 ARG 366 350 350 ARG ARG B . n B 1 367 LEU 367 351 351 LEU LEU B . n B 1 368 ILE 368 352 352 ILE ILE B . n B 1 369 THR 369 353 353 THR THR B . n B 1 370 ALA 370 354 354 ALA ALA B . n B 1 371 ASN 371 355 355 ASN ASN B . n B 1 372 PRO 372 356 356 PRO PRO B . n B 1 373 ILE 373 357 357 ILE ILE B . n B 1 374 VAL 374 358 358 VAL VAL B . n B 1 375 THR 375 359 359 THR THR B . n B 1 376 ASP 376 360 360 ASP ASP B . n B 1 377 LYS 377 361 361 LYS LYS B . n B 1 378 GLU 378 362 362 GLU ALA B . n B 1 379 LYS 379 363 363 LYS LYS B . n B 1 380 PRO 380 364 364 PRO PRO B . n B 1 381 VAL 381 365 365 VAL VAL B . n B 1 382 ASN 382 366 366 ASN ASN B . n B 1 383 ILE 383 367 367 ILE ILE B . n B 1 384 GLU 384 368 368 GLU GLU B . n B 1 385 ALA 385 369 369 ALA ALA B . n B 1 386 GLU 386 370 370 GLU GLU B . n B 1 387 PRO 387 371 371 PRO PRO B . n B 1 388 PRO 388 372 372 PRO PRO B . n B 1 389 PHE 389 373 373 PHE PHE B . n B 1 390 GLY 390 374 374 GLY GLY B . n B 1 391 GLU 391 375 375 GLU GLU B . n B 1 392 SER 392 376 376 SER SER B . n B 1 393 TYR 393 377 377 TYR TYR B . n B 1 394 ILE 394 378 378 ILE ILE B . n B 1 395 VAL 395 379 379 VAL VAL B . n B 1 396 VAL 396 380 380 VAL VAL B . n B 1 397 GLY 397 381 381 GLY GLY B . n B 1 398 ALA 398 382 382 ALA ALA B . n B 1 399 GLY 399 383 383 GLY GLY B . n B 1 400 GLU 400 384 384 GLU GLU B . n B 1 401 LYS 401 385 385 LYS ALA B . n B 1 402 ALA 402 386 386 ALA ALA B . n B 1 403 LEU 403 387 387 LEU LEU B . n B 1 404 LYS 404 388 388 LYS LYS B . n B 1 405 LEU 405 389 389 LEU LEU B . n B 1 406 SER 406 390 390 SER SER B . n B 1 407 TRP 407 391 391 TRP TRP B . n B 1 408 PHE 408 392 392 PHE PHE B . n B 1 409 LYS 409 393 393 LYS LYS B . n B 1 410 LYS 410 394 394 LYS LYS B . n B 1 411 GLY 411 395 395 GLY GLY B . n B 1 412 SER 412 396 396 SER SER B . n B 1 413 SER 413 397 397 SER SER B . n B 1 414 ILE 414 398 398 ILE ILE B . n B 1 415 GLY 415 399 399 GLY GLY B . n B 1 416 LYS 416 400 400 LYS LYS B . n B 1 417 MET 417 401 401 MET MET B . n B 1 418 PHE 418 402 402 PHE PHE B . n B 1 419 GLU 419 403 403 GLU GLU B . n B 1 420 ALA 420 404 404 ALA ALA B . n B 1 421 THR 421 405 ? ? ? B . n B 1 422 ALA 422 406 ? ? ? B . n B 1 423 ARG 423 407 ? ? ? B . n B 1 424 GLY 424 408 ? ? ? B . n B 1 425 ALA 425 409 ? ? ? B . n B 1 426 ARG 426 410 ? ? ? B . n B 1 427 ARG 427 411 ? ? ? B . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code C 2 NAG 1 501 431 NAG NAG A . D 3 CD 1 502 2 CD CD A . E 3 CD 1 503 3 CD CD A . F 4 CL 1 504 1 CL CL A . G 2 NAG 1 501 431 NAG NAG B . H 3 CD 1 502 1 CD CD B . I 3 CD 1 503 4 CD CD B . J 5 HOH 1 601 2 HOH HOH A . J 5 HOH 2 602 4 HOH HOH A . J 5 HOH 3 603 7 HOH HOH A . J 5 HOH 4 604 11 HOH HOH A . J 5 HOH 5 605 13 HOH HOH A . J 5 HOH 6 606 15 HOH HOH A . J 5 HOH 7 607 21 HOH HOH A . J 5 HOH 8 608 23 HOH HOH A . J 5 HOH 9 609 24 HOH HOH A . J 5 HOH 10 610 25 HOH HOH A . J 5 HOH 11 611 28 HOH HOH A . J 5 HOH 12 612 31 HOH HOH A . J 5 HOH 13 613 32 HOH HOH A . J 5 HOH 14 614 33 HOH HOH A . J 5 HOH 15 615 34 HOH HOH A . J 5 HOH 16 616 35 HOH HOH A . J 5 HOH 17 617 38 HOH HOH A . J 5 HOH 18 618 42 HOH HOH A . J 5 HOH 19 619 43 HOH HOH A . J 5 HOH 20 620 44 HOH HOH A . J 5 HOH 21 621 45 HOH HOH A . J 5 HOH 22 622 47 HOH HOH A . J 5 HOH 23 623 48 HOH HOH A . J 5 HOH 24 624 50 HOH HOH A . J 5 HOH 25 625 52 HOH HOH A . J 5 HOH 26 626 53 HOH HOH A . J 5 HOH 27 627 54 HOH HOH A . J 5 HOH 28 628 55 HOH HOH A . J 5 HOH 29 629 57 HOH HOH A . J 5 HOH 30 630 60 HOH HOH A . J 5 HOH 31 631 62 HOH HOH A . J 5 HOH 32 632 63 HOH HOH A . J 5 HOH 33 633 64 HOH HOH A . J 5 HOH 34 634 65 HOH HOH A . J 5 HOH 35 635 67 HOH HOH A . J 5 HOH 36 636 68 HOH HOH A . J 5 HOH 37 637 72 HOH HOH A . J 5 HOH 38 638 73 HOH HOH A . J 5 HOH 39 639 75 HOH HOH A . J 5 HOH 40 640 76 HOH HOH A . J 5 HOH 41 641 79 HOH HOH A . J 5 HOH 42 642 80 HOH HOH A . J 5 HOH 43 643 81 HOH HOH A . J 5 HOH 44 644 82 HOH HOH A . J 5 HOH 45 645 85 HOH HOH A . J 5 HOH 46 646 86 HOH HOH A . J 5 HOH 47 647 87 HOH HOH A . J 5 HOH 48 648 89 HOH HOH A . J 5 HOH 49 649 91 HOH HOH A . J 5 HOH 50 650 93 HOH HOH A . J 5 HOH 51 651 94 HOH HOH A . J 5 HOH 52 652 95 HOH HOH A . J 5 HOH 53 653 96 HOH HOH A . J 5 HOH 54 654 97 HOH HOH A . J 5 HOH 55 655 98 HOH HOH A . J 5 HOH 56 656 102 HOH HOH A . J 5 HOH 57 657 106 HOH HOH A . J 5 HOH 58 658 111 HOH HOH A . J 5 HOH 59 659 113 HOH HOH A . J 5 HOH 60 660 114 HOH HOH A . J 5 HOH 61 661 119 HOH HOH A . J 5 HOH 62 662 120 HOH HOH A . J 5 HOH 63 663 121 HOH HOH A . J 5 HOH 64 664 122 HOH HOH A . J 5 HOH 65 665 123 HOH HOH A . J 5 HOH 66 666 125 HOH HOH A . J 5 HOH 67 667 126 HOH HOH A . J 5 HOH 68 668 127 HOH HOH A . J 5 HOH 69 669 128 HOH HOH A . J 5 HOH 70 670 129 HOH HOH A . J 5 HOH 71 671 130 HOH HOH A . J 5 HOH 72 672 133 HOH HOH A . J 5 HOH 73 673 134 HOH HOH A . J 5 HOH 74 674 135 HOH HOH A . J 5 HOH 75 675 136 HOH HOH A . J 5 HOH 76 676 137 HOH HOH A . J 5 HOH 77 677 138 HOH HOH A . J 5 HOH 78 678 142 HOH HOH A . J 5 HOH 79 679 143 HOH HOH A . J 5 HOH 80 680 144 HOH HOH A . J 5 HOH 81 681 145 HOH HOH A . J 5 HOH 82 682 147 HOH HOH A . J 5 HOH 83 683 148 HOH HOH A . J 5 HOH 84 684 149 HOH HOH A . J 5 HOH 85 685 151 HOH HOH A . J 5 HOH 86 686 152 HOH HOH A . J 5 HOH 87 687 153 HOH HOH A . J 5 HOH 88 688 155 HOH HOH A . J 5 HOH 89 689 156 HOH HOH A . J 5 HOH 90 690 157 HOH HOH A . J 5 HOH 91 691 158 HOH HOH A . J 5 HOH 92 692 159 HOH HOH A . J 5 HOH 93 693 160 HOH HOH A . J 5 HOH 94 694 163 HOH HOH A . J 5 HOH 95 695 164 HOH HOH A . J 5 HOH 96 696 165 HOH HOH A . J 5 HOH 97 697 166 HOH HOH A . J 5 HOH 98 698 168 HOH HOH A . J 5 HOH 99 699 169 HOH HOH A . J 5 HOH 100 700 170 HOH HOH A . J 5 HOH 101 701 171 HOH HOH A . J 5 HOH 102 702 172 HOH HOH A . J 5 HOH 103 703 174 HOH HOH A . J 5 HOH 104 704 176 HOH HOH A . J 5 HOH 105 705 177 HOH HOH A . J 5 HOH 106 706 178 HOH HOH A . J 5 HOH 107 707 182 HOH HOH A . J 5 HOH 108 708 183 HOH HOH A . J 5 HOH 109 709 184 HOH HOH A . J 5 HOH 110 710 185 HOH HOH A . J 5 HOH 111 711 186 HOH HOH A . J 5 HOH 112 712 188 HOH HOH A . J 5 HOH 113 713 189 HOH HOH A . J 5 HOH 114 714 190 HOH HOH A . J 5 HOH 115 715 193 HOH HOH A . J 5 HOH 116 716 197 HOH HOH A . J 5 HOH 117 717 199 HOH HOH A . J 5 HOH 118 718 201 HOH HOH A . J 5 HOH 119 719 202 HOH HOH A . J 5 HOH 120 720 205 HOH HOH A . J 5 HOH 121 721 206 HOH HOH A . J 5 HOH 122 722 209 HOH HOH A . J 5 HOH 123 723 210 HOH HOH A . J 5 HOH 124 724 212 HOH HOH A . J 5 HOH 125 725 213 HOH HOH A . J 5 HOH 126 726 215 HOH HOH A . J 5 HOH 127 727 216 HOH HOH A . J 5 HOH 128 728 219 HOH HOH A . J 5 HOH 129 729 220 HOH HOH A . J 5 HOH 130 730 222 HOH HOH A . J 5 HOH 131 731 224 HOH HOH A . J 5 HOH 132 732 228 HOH HOH A . J 5 HOH 133 733 229 HOH HOH A . J 5 HOH 134 734 230 HOH HOH A . J 5 HOH 135 735 235 HOH HOH A . J 5 HOH 136 736 236 HOH HOH A . J 5 HOH 137 737 237 HOH HOH A . J 5 HOH 138 738 238 HOH HOH A . J 5 HOH 139 739 242 HOH HOH A . J 5 HOH 140 740 244 HOH HOH A . J 5 HOH 141 741 245 HOH HOH A . J 5 HOH 142 742 246 HOH HOH A . J 5 HOH 143 743 248 HOH HOH A . J 5 HOH 144 744 249 HOH HOH A . J 5 HOH 145 745 251 HOH HOH A . J 5 HOH 146 746 252 HOH HOH A . J 5 HOH 147 747 253 HOH HOH A . J 5 HOH 148 748 256 HOH HOH A . J 5 HOH 149 749 258 HOH HOH A . J 5 HOH 150 750 259 HOH HOH A . J 5 HOH 151 751 262 HOH HOH A . J 5 HOH 152 752 265 HOH HOH A . J 5 HOH 153 753 266 HOH HOH A . J 5 HOH 154 754 267 HOH HOH A . J 5 HOH 155 755 268 HOH HOH A . J 5 HOH 156 756 270 HOH HOH A . J 5 HOH 157 757 271 HOH HOH A . J 5 HOH 158 758 273 HOH HOH A . J 5 HOH 159 759 277 HOH HOH A . J 5 HOH 160 760 278 HOH HOH A . J 5 HOH 161 761 279 HOH HOH A . J 5 HOH 162 762 282 HOH HOH A . J 5 HOH 163 763 283 HOH HOH A . J 5 HOH 164 764 284 HOH HOH A . J 5 HOH 165 765 285 HOH HOH A . J 5 HOH 166 766 287 HOH HOH A . J 5 HOH 167 767 288 HOH HOH A . J 5 HOH 168 768 291 HOH HOH A . J 5 HOH 169 769 293 HOH HOH A . J 5 HOH 170 770 297 HOH HOH A . J 5 HOH 171 771 299 HOH HOH A . J 5 HOH 172 772 300 HOH HOH A . J 5 HOH 173 773 303 HOH HOH A . J 5 HOH 174 774 304 HOH HOH A . J 5 HOH 175 775 306 HOH HOH A . J 5 HOH 176 776 310 HOH HOH A . J 5 HOH 177 777 311 HOH HOH A . J 5 HOH 178 778 312 HOH HOH A . J 5 HOH 179 779 313 HOH HOH A . J 5 HOH 180 780 315 HOH HOH A . J 5 HOH 181 781 319 HOH HOH A . J 5 HOH 182 782 320 HOH HOH A . J 5 HOH 183 783 321 HOH HOH A . J 5 HOH 184 784 322 HOH HOH A . J 5 HOH 185 785 323 HOH HOH A . J 5 HOH 186 786 328 HOH HOH A . J 5 HOH 187 787 330 HOH HOH A . J 5 HOH 188 788 333 HOH HOH A . J 5 HOH 189 789 336 HOH HOH A . J 5 HOH 190 790 337 HOH HOH A . J 5 HOH 191 791 342 HOH HOH A . J 5 HOH 192 792 344 HOH HOH A . J 5 HOH 193 793 345 HOH HOH A . J 5 HOH 194 794 348 HOH HOH A . J 5 HOH 195 795 351 HOH HOH A . J 5 HOH 196 796 352 HOH HOH A . J 5 HOH 197 797 354 HOH HOH A . J 5 HOH 198 798 355 HOH HOH A . J 5 HOH 199 799 356 HOH HOH A . J 5 HOH 200 800 359 HOH HOH A . J 5 HOH 201 801 360 HOH HOH A . J 5 HOH 202 802 362 HOH HOH A . J 5 HOH 203 803 364 HOH HOH A . J 5 HOH 204 804 367 HOH HOH A . J 5 HOH 205 805 369 HOH HOH A . J 5 HOH 206 806 370 HOH HOH A . J 5 HOH 207 807 375 HOH HOH A . J 5 HOH 208 808 377 HOH HOH A . J 5 HOH 209 809 380 HOH HOH A . J 5 HOH 210 810 385 HOH HOH A . J 5 HOH 211 811 386 HOH HOH A . J 5 HOH 212 812 387 HOH HOH A . J 5 HOH 213 813 389 HOH HOH A . J 5 HOH 214 814 390 HOH HOH A . J 5 HOH 215 815 392 HOH HOH A . J 5 HOH 216 816 393 HOH HOH A . J 5 HOH 217 817 394 HOH HOH A . J 5 HOH 218 818 396 HOH HOH A . J 5 HOH 219 819 398 HOH HOH A . J 5 HOH 220 820 400 HOH HOH A . J 5 HOH 221 821 401 HOH HOH A . J 5 HOH 222 822 402 HOH HOH A . J 5 HOH 223 823 403 HOH HOH A . J 5 HOH 224 824 404 HOH HOH A . J 5 HOH 225 825 405 HOH HOH A . J 5 HOH 226 826 406 HOH HOH A . J 5 HOH 227 827 407 HOH HOH A . J 5 HOH 228 828 409 HOH HOH A . J 5 HOH 229 829 411 HOH HOH A . J 5 HOH 230 830 415 HOH HOH A . J 5 HOH 231 831 419 HOH HOH A . J 5 HOH 232 832 420 HOH HOH A . J 5 HOH 233 833 421 HOH HOH A . J 5 HOH 234 834 422 HOH HOH A . J 5 HOH 235 835 423 HOH HOH A . J 5 HOH 236 836 424 HOH HOH A . J 5 HOH 237 837 428 HOH HOH A . J 5 HOH 238 838 430 HOH HOH A . J 5 HOH 239 839 431 HOH HOH A . J 5 HOH 240 840 436 HOH HOH A . J 5 HOH 241 841 437 HOH HOH A . J 5 HOH 242 842 439 HOH HOH A . J 5 HOH 243 843 440 HOH HOH A . J 5 HOH 244 844 442 HOH HOH A . J 5 HOH 245 845 443 HOH HOH A . J 5 HOH 246 846 450 HOH HOH A . J 5 HOH 247 847 451 HOH HOH A . J 5 HOH 248 848 452 HOH HOH A . J 5 HOH 249 849 453 HOH HOH A . J 5 HOH 250 850 454 HOH HOH A . J 5 HOH 251 851 455 HOH HOH A . J 5 HOH 252 852 456 HOH HOH A . J 5 HOH 253 853 458 HOH HOH A . J 5 HOH 254 854 460 HOH HOH A . J 5 HOH 255 855 461 HOH HOH A . J 5 HOH 256 856 462 HOH HOH A . J 5 HOH 257 857 469 HOH HOH A . J 5 HOH 258 858 470 HOH HOH A . J 5 HOH 259 859 473 HOH HOH A . J 5 HOH 260 860 474 HOH HOH A . J 5 HOH 261 861 477 HOH HOH A . J 5 HOH 262 862 478 HOH HOH A . J 5 HOH 263 863 479 HOH HOH A . J 5 HOH 264 864 480 HOH HOH A . J 5 HOH 265 865 482 HOH HOH A . J 5 HOH 266 866 483 HOH HOH A . J 5 HOH 267 867 484 HOH HOH A . J 5 HOH 268 868 487 HOH HOH A . J 5 HOH 269 869 488 HOH HOH A . J 5 HOH 270 870 490 HOH HOH A . J 5 HOH 271 871 491 HOH HOH A . J 5 HOH 272 872 492 HOH HOH A . J 5 HOH 273 873 493 HOH HOH A . J 5 HOH 274 874 494 HOH HOH A . J 5 HOH 275 875 495 HOH HOH A . J 5 HOH 276 876 497 HOH HOH A . J 5 HOH 277 877 498 HOH HOH A . J 5 HOH 278 878 499 HOH HOH A . J 5 HOH 279 879 501 HOH HOH A . J 5 HOH 280 880 503 HOH HOH A . J 5 HOH 281 881 505 HOH HOH A . J 5 HOH 282 882 506 HOH HOH A . J 5 HOH 283 883 507 HOH HOH A . J 5 HOH 284 884 508 HOH HOH A . J 5 HOH 285 885 509 HOH HOH A . J 5 HOH 286 886 511 HOH HOH A . J 5 HOH 287 887 512 HOH HOH A . J 5 HOH 288 888 514 HOH HOH A . J 5 HOH 289 889 515 HOH HOH A . J 5 HOH 290 890 516 HOH HOH A . J 5 HOH 291 891 517 HOH HOH A . J 5 HOH 292 892 518 HOH HOH A . J 5 HOH 293 893 519 HOH HOH A . J 5 HOH 294 894 520 HOH HOH A . J 5 HOH 295 895 522 HOH HOH A . J 5 HOH 296 896 523 HOH HOH A . J 5 HOH 297 897 524 HOH HOH A . J 5 HOH 298 898 525 HOH HOH A . J 5 HOH 299 899 529 HOH HOH A . J 5 HOH 300 900 530 HOH HOH A . J 5 HOH 301 901 532 HOH HOH A . J 5 HOH 302 902 535 HOH HOH A . J 5 HOH 303 903 537 HOH HOH A . J 5 HOH 304 904 538 HOH HOH A . J 5 HOH 305 905 539 HOH HOH A . J 5 HOH 306 906 540 HOH HOH A . J 5 HOH 307 907 541 HOH HOH A . J 5 HOH 308 908 543 HOH HOH A . J 5 HOH 309 909 546 HOH HOH A . J 5 HOH 310 910 551 HOH HOH A . J 5 HOH 311 911 554 HOH HOH A . J 5 HOH 312 912 556 HOH HOH A . J 5 HOH 313 913 560 HOH HOH A . J 5 HOH 314 914 561 HOH HOH A . J 5 HOH 315 915 568 HOH HOH A . J 5 HOH 316 916 569 HOH HOH A . J 5 HOH 317 917 573 HOH HOH A . J 5 HOH 318 918 576 HOH HOH A . J 5 HOH 319 919 578 HOH HOH A . J 5 HOH 320 920 580 HOH HOH A . J 5 HOH 321 921 581 HOH HOH A . J 5 HOH 322 922 582 HOH HOH A . J 5 HOH 323 923 585 HOH HOH A . J 5 HOH 324 924 586 HOH HOH A . J 5 HOH 325 925 589 HOH HOH A . J 5 HOH 326 926 592 HOH HOH A . J 5 HOH 327 927 595 HOH HOH A . J 5 HOH 328 928 596 HOH HOH A . J 5 HOH 329 929 598 HOH HOH A . J 5 HOH 330 930 599 HOH HOH A . J 5 HOH 331 931 602 HOH HOH A . J 5 HOH 332 932 603 HOH HOH A . J 5 HOH 333 933 604 HOH HOH A . J 5 HOH 334 934 605 HOH HOH A . J 5 HOH 335 935 606 HOH HOH A . J 5 HOH 336 936 607 HOH HOH A . J 5 HOH 337 937 609 HOH HOH A . J 5 HOH 338 938 611 HOH HOH A . J 5 HOH 339 939 613 HOH HOH A . J 5 HOH 340 940 614 HOH HOH A . J 5 HOH 341 941 617 HOH HOH A . J 5 HOH 342 942 621 HOH HOH A . J 5 HOH 343 943 623 HOH HOH A . J 5 HOH 344 944 625 HOH HOH A . J 5 HOH 345 945 627 HOH HOH A . J 5 HOH 346 946 629 HOH HOH A . J 5 HOH 347 947 633 HOH HOH A . J 5 HOH 348 948 634 HOH HOH A . J 5 HOH 349 949 638 HOH HOH A . J 5 HOH 350 950 640 HOH HOH A . J 5 HOH 351 951 641 HOH HOH A . J 5 HOH 352 952 642 HOH HOH A . J 5 HOH 353 953 643 HOH HOH A . J 5 HOH 354 954 644 HOH HOH A . J 5 HOH 355 955 650 HOH HOH A . J 5 HOH 356 956 655 HOH HOH A . J 5 HOH 357 957 659 HOH HOH A . J 5 HOH 358 958 662 HOH HOH A . J 5 HOH 359 959 663 HOH HOH A . J 5 HOH 360 960 664 HOH HOH A . K 5 HOH 1 601 1 HOH HOH B . K 5 HOH 2 602 3 HOH HOH B . K 5 HOH 3 603 5 HOH HOH B . K 5 HOH 4 604 6 HOH HOH B . K 5 HOH 5 605 8 HOH HOH B . K 5 HOH 6 606 9 HOH HOH B . K 5 HOH 7 607 10 HOH HOH B . K 5 HOH 8 608 12 HOH HOH B . K 5 HOH 9 609 14 HOH HOH B . K 5 HOH 10 610 16 HOH HOH B . K 5 HOH 11 611 17 HOH HOH B . K 5 HOH 12 612 18 HOH HOH B . K 5 HOH 13 613 19 HOH HOH B . K 5 HOH 14 614 20 HOH HOH B . K 5 HOH 15 615 22 HOH HOH B . K 5 HOH 16 616 26 HOH HOH B . K 5 HOH 17 617 27 HOH HOH B . K 5 HOH 18 618 29 HOH HOH B . K 5 HOH 19 619 30 HOH HOH B . K 5 HOH 20 620 36 HOH HOH B . K 5 HOH 21 621 37 HOH HOH B . K 5 HOH 22 622 39 HOH HOH B . K 5 HOH 23 623 40 HOH HOH B . K 5 HOH 24 624 41 HOH HOH B . K 5 HOH 25 625 46 HOH HOH B . K 5 HOH 26 626 49 HOH HOH B . K 5 HOH 27 627 51 HOH HOH B . K 5 HOH 28 628 56 HOH HOH B . K 5 HOH 29 629 58 HOH HOH B . K 5 HOH 30 630 59 HOH HOH B . K 5 HOH 31 631 61 HOH HOH B . K 5 HOH 32 632 66 HOH HOH B . K 5 HOH 33 633 69 HOH HOH B . K 5 HOH 34 634 70 HOH HOH B . K 5 HOH 35 635 71 HOH HOH B . K 5 HOH 36 636 74 HOH HOH B . K 5 HOH 37 637 77 HOH HOH B . K 5 HOH 38 638 78 HOH HOH B . K 5 HOH 39 639 83 HOH HOH B . K 5 HOH 40 640 84 HOH HOH B . K 5 HOH 41 641 88 HOH HOH B . K 5 HOH 42 642 90 HOH HOH B . K 5 HOH 43 643 92 HOH HOH B . K 5 HOH 44 644 99 HOH HOH B . K 5 HOH 45 645 100 HOH HOH B . K 5 HOH 46 646 101 HOH HOH B . K 5 HOH 47 647 103 HOH HOH B . K 5 HOH 48 648 104 HOH HOH B . K 5 HOH 49 649 105 HOH HOH B . K 5 HOH 50 650 107 HOH HOH B . K 5 HOH 51 651 108 HOH HOH B . K 5 HOH 52 652 109 HOH HOH B . K 5 HOH 53 653 110 HOH HOH B . K 5 HOH 54 654 112 HOH HOH B . K 5 HOH 55 655 115 HOH HOH B . K 5 HOH 56 656 116 HOH HOH B . K 5 HOH 57 657 117 HOH HOH B . K 5 HOH 58 658 118 HOH HOH B . K 5 HOH 59 659 124 HOH HOH B . K 5 HOH 60 660 131 HOH HOH B . K 5 HOH 61 661 132 HOH HOH B . K 5 HOH 62 662 139 HOH HOH B . K 5 HOH 63 663 140 HOH HOH B . K 5 HOH 64 664 141 HOH HOH B . K 5 HOH 65 665 146 HOH HOH B . K 5 HOH 66 666 150 HOH HOH B . K 5 HOH 67 667 154 HOH HOH B . K 5 HOH 68 668 161 HOH HOH B . K 5 HOH 69 669 162 HOH HOH B . K 5 HOH 70 670 167 HOH HOH B . K 5 HOH 71 671 173 HOH HOH B . K 5 HOH 72 672 175 HOH HOH B . K 5 HOH 73 673 179 HOH HOH B . K 5 HOH 74 674 180 HOH HOH B . K 5 HOH 75 675 181 HOH HOH B . K 5 HOH 76 676 187 HOH HOH B . K 5 HOH 77 677 191 HOH HOH B . K 5 HOH 78 678 192 HOH HOH B . K 5 HOH 79 679 194 HOH HOH B . K 5 HOH 80 680 195 HOH HOH B . K 5 HOH 81 681 196 HOH HOH B . K 5 HOH 82 682 198 HOH HOH B . K 5 HOH 83 683 200 HOH HOH B . K 5 HOH 84 684 203 HOH HOH B . K 5 HOH 85 685 204 HOH HOH B . K 5 HOH 86 686 207 HOH HOH B . K 5 HOH 87 687 208 HOH HOH B . K 5 HOH 88 688 211 HOH HOH B . K 5 HOH 89 689 214 HOH HOH B . K 5 HOH 90 690 217 HOH HOH B . K 5 HOH 91 691 218 HOH HOH B . K 5 HOH 92 692 221 HOH HOH B . K 5 HOH 93 693 223 HOH HOH B . K 5 HOH 94 694 225 HOH HOH B . K 5 HOH 95 695 226 HOH HOH B . K 5 HOH 96 696 227 HOH HOH B . K 5 HOH 97 697 231 HOH HOH B . K 5 HOH 98 698 232 HOH HOH B . K 5 HOH 99 699 233 HOH HOH B . K 5 HOH 100 700 234 HOH HOH B . K 5 HOH 101 701 239 HOH HOH B . K 5 HOH 102 702 240 HOH HOH B . K 5 HOH 103 703 241 HOH HOH B . K 5 HOH 104 704 243 HOH HOH B . K 5 HOH 105 705 247 HOH HOH B . K 5 HOH 106 706 250 HOH HOH B . K 5 HOH 107 707 254 HOH HOH B . K 5 HOH 108 708 255 HOH HOH B . K 5 HOH 109 709 257 HOH HOH B . K 5 HOH 110 710 260 HOH HOH B . K 5 HOH 111 711 261 HOH HOH B . K 5 HOH 112 712 263 HOH HOH B . K 5 HOH 113 713 264 HOH HOH B . K 5 HOH 114 714 269 HOH HOH B . K 5 HOH 115 715 272 HOH HOH B . K 5 HOH 116 716 274 HOH HOH B . K 5 HOH 117 717 275 HOH HOH B . K 5 HOH 118 718 276 HOH HOH B . K 5 HOH 119 719 280 HOH HOH B . K 5 HOH 120 720 281 HOH HOH B . K 5 HOH 121 721 286 HOH HOH B . K 5 HOH 122 722 289 HOH HOH B . K 5 HOH 123 723 290 HOH HOH B . K 5 HOH 124 724 292 HOH HOH B . K 5 HOH 125 725 294 HOH HOH B . K 5 HOH 126 726 295 HOH HOH B . K 5 HOH 127 727 296 HOH HOH B . K 5 HOH 128 728 298 HOH HOH B . K 5 HOH 129 729 301 HOH HOH B . K 5 HOH 130 730 302 HOH HOH B . K 5 HOH 131 731 305 HOH HOH B . K 5 HOH 132 732 307 HOH HOH B . K 5 HOH 133 733 308 HOH HOH B . K 5 HOH 134 734 309 HOH HOH B . K 5 HOH 135 735 314 HOH HOH B . K 5 HOH 136 736 316 HOH HOH B . K 5 HOH 137 737 317 HOH HOH B . K 5 HOH 138 738 318 HOH HOH B . K 5 HOH 139 739 324 HOH HOH B . K 5 HOH 140 740 325 HOH HOH B . K 5 HOH 141 741 326 HOH HOH B . K 5 HOH 142 742 327 HOH HOH B . K 5 HOH 143 743 329 HOH HOH B . K 5 HOH 144 744 331 HOH HOH B . K 5 HOH 145 745 332 HOH HOH B . K 5 HOH 146 746 334 HOH HOH B . K 5 HOH 147 747 335 HOH HOH B . K 5 HOH 148 748 338 HOH HOH B . K 5 HOH 149 749 339 HOH HOH B . K 5 HOH 150 750 340 HOH HOH B . K 5 HOH 151 751 341 HOH HOH B . K 5 HOH 152 752 343 HOH HOH B . K 5 HOH 153 753 346 HOH HOH B . K 5 HOH 154 754 347 HOH HOH B . K 5 HOH 155 755 349 HOH HOH B . K 5 HOH 156 756 350 HOH HOH B . K 5 HOH 157 757 353 HOH HOH B . K 5 HOH 158 758 357 HOH HOH B . K 5 HOH 159 759 358 HOH HOH B . K 5 HOH 160 760 361 HOH HOH B . K 5 HOH 161 761 363 HOH HOH B . K 5 HOH 162 762 365 HOH HOH B . K 5 HOH 163 763 366 HOH HOH B . K 5 HOH 164 764 368 HOH HOH B . K 5 HOH 165 765 371 HOH HOH B . K 5 HOH 166 766 372 HOH HOH B . K 5 HOH 167 767 373 HOH HOH B . K 5 HOH 168 768 374 HOH HOH B . K 5 HOH 169 769 376 HOH HOH B . K 5 HOH 170 770 378 HOH HOH B . K 5 HOH 171 771 379 HOH HOH B . K 5 HOH 172 772 381 HOH HOH B . K 5 HOH 173 773 382 HOH HOH B . K 5 HOH 174 774 383 HOH HOH B . K 5 HOH 175 775 384 HOH HOH B . K 5 HOH 176 776 388 HOH HOH B . K 5 HOH 177 777 391 HOH HOH B . K 5 HOH 178 778 395 HOH HOH B . K 5 HOH 179 779 397 HOH HOH B . K 5 HOH 180 780 399 HOH HOH B . K 5 HOH 181 781 408 HOH HOH B . K 5 HOH 182 782 410 HOH HOH B . K 5 HOH 183 783 412 HOH HOH B . K 5 HOH 184 784 413 HOH HOH B . K 5 HOH 185 785 414 HOH HOH B . K 5 HOH 186 786 416 HOH HOH B . K 5 HOH 187 787 417 HOH HOH B . K 5 HOH 188 788 418 HOH HOH B . K 5 HOH 189 789 425 HOH HOH B . K 5 HOH 190 790 426 HOH HOH B . K 5 HOH 191 791 427 HOH HOH B . K 5 HOH 192 792 429 HOH HOH B . K 5 HOH 193 793 432 HOH HOH B . K 5 HOH 194 794 433 HOH HOH B . K 5 HOH 195 795 434 HOH HOH B . K 5 HOH 196 796 435 HOH HOH B . K 5 HOH 197 797 438 HOH HOH B . K 5 HOH 198 798 441 HOH HOH B . K 5 HOH 199 799 444 HOH HOH B . K 5 HOH 200 800 445 HOH HOH B . K 5 HOH 201 801 446 HOH HOH B . K 5 HOH 202 802 447 HOH HOH B . K 5 HOH 203 803 448 HOH HOH B . K 5 HOH 204 804 449 HOH HOH B . K 5 HOH 205 805 457 HOH HOH B . K 5 HOH 206 806 459 HOH HOH B . K 5 HOH 207 807 463 HOH HOH B . K 5 HOH 208 808 464 HOH HOH B . K 5 HOH 209 809 465 HOH HOH B . K 5 HOH 210 810 466 HOH HOH B . K 5 HOH 211 811 467 HOH HOH B . K 5 HOH 212 812 468 HOH HOH B . K 5 HOH 213 813 471 HOH HOH B . K 5 HOH 214 814 472 HOH HOH B . K 5 HOH 215 815 475 HOH HOH B . K 5 HOH 216 816 476 HOH HOH B . K 5 HOH 217 817 481 HOH HOH B . K 5 HOH 218 818 485 HOH HOH B . K 5 HOH 219 819 486 HOH HOH B . K 5 HOH 220 820 489 HOH HOH B . K 5 HOH 221 821 496 HOH HOH B . K 5 HOH 222 822 500 HOH HOH B . K 5 HOH 223 823 502 HOH HOH B . K 5 HOH 224 824 504 HOH HOH B . K 5 HOH 225 825 510 HOH HOH B . K 5 HOH 226 826 513 HOH HOH B . K 5 HOH 227 827 521 HOH HOH B . K 5 HOH 228 828 526 HOH HOH B . K 5 HOH 229 829 527 HOH HOH B . K 5 HOH 230 830 528 HOH HOH B . K 5 HOH 231 831 531 HOH HOH B . K 5 HOH 232 832 533 HOH HOH B . K 5 HOH 233 833 534 HOH HOH B . K 5 HOH 234 834 536 HOH HOH B . K 5 HOH 235 835 542 HOH HOH B . K 5 HOH 236 836 544 HOH HOH B . K 5 HOH 237 837 545 HOH HOH B . K 5 HOH 238 838 547 HOH HOH B . K 5 HOH 239 839 548 HOH HOH B . K 5 HOH 240 840 549 HOH HOH B . K 5 HOH 241 841 550 HOH HOH B . K 5 HOH 242 842 552 HOH HOH B . K 5 HOH 243 843 553 HOH HOH B . K 5 HOH 244 844 555 HOH HOH B . K 5 HOH 245 845 557 HOH HOH B . K 5 HOH 246 846 558 HOH HOH B . K 5 HOH 247 847 559 HOH HOH B . K 5 HOH 248 848 562 HOH HOH B . K 5 HOH 249 849 563 HOH HOH B . K 5 HOH 250 850 564 HOH HOH B . K 5 HOH 251 851 565 HOH HOH B . K 5 HOH 252 852 566 HOH HOH B . K 5 HOH 253 853 567 HOH HOH B . K 5 HOH 254 854 570 HOH HOH B . K 5 HOH 255 855 571 HOH HOH B . K 5 HOH 256 856 572 HOH HOH B . K 5 HOH 257 857 574 HOH HOH B . K 5 HOH 258 858 575 HOH HOH B . K 5 HOH 259 859 577 HOH HOH B . K 5 HOH 260 860 579 HOH HOH B . K 5 HOH 261 861 583 HOH HOH B . K 5 HOH 262 862 584 HOH HOH B . K 5 HOH 263 863 587 HOH HOH B . K 5 HOH 264 864 588 HOH HOH B . K 5 HOH 265 865 590 HOH HOH B . K 5 HOH 266 866 591 HOH HOH B . K 5 HOH 267 867 593 HOH HOH B . K 5 HOH 268 868 594 HOH HOH B . K 5 HOH 269 869 597 HOH HOH B . K 5 HOH 270 870 600 HOH HOH B . K 5 HOH 271 871 601 HOH HOH B . K 5 HOH 272 872 608 HOH HOH B . K 5 HOH 273 873 610 HOH HOH B . K 5 HOH 274 874 612 HOH HOH B . K 5 HOH 275 875 615 HOH HOH B . K 5 HOH 276 876 616 HOH HOH B . K 5 HOH 277 877 618 HOH HOH B . K 5 HOH 278 878 619 HOH HOH B . K 5 HOH 279 879 620 HOH HOH B . K 5 HOH 280 880 622 HOH HOH B . K 5 HOH 281 881 624 HOH HOH B . K 5 HOH 282 882 626 HOH HOH B . K 5 HOH 283 883 628 HOH HOH B . K 5 HOH 284 884 630 HOH HOH B . K 5 HOH 285 885 631 HOH HOH B . K 5 HOH 286 886 632 HOH HOH B . K 5 HOH 287 887 635 HOH HOH B . K 5 HOH 288 888 636 HOH HOH B . K 5 HOH 289 889 637 HOH HOH B . K 5 HOH 290 890 639 HOH HOH B . K 5 HOH 291 891 645 HOH HOH B . K 5 HOH 292 892 646 HOH HOH B . K 5 HOH 293 893 647 HOH HOH B . K 5 HOH 294 894 648 HOH HOH B . K 5 HOH 295 895 649 HOH HOH B . K 5 HOH 296 896 651 HOH HOH B . K 5 HOH 297 897 652 HOH HOH B . K 5 HOH 298 898 653 HOH HOH B . K 5 HOH 299 899 654 HOH HOH B . K 5 HOH 300 900 656 HOH HOH B . K 5 HOH 301 901 657 HOH HOH B . K 5 HOH 302 902 658 HOH HOH B . K 5 HOH 303 903 660 HOH HOH B . K 5 HOH 304 904 661 HOH HOH B . K 5 HOH 305 905 665 HOH HOH B . K 5 HOH 306 906 666 HOH HOH B . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 83 A ASN 67 ? ASN 'GLYCOSYLATION SITE' 2 B ASN 83 B ASN 67 ? ASN 'GLYCOSYLATION SITE' # loop_ _pdbx_struct_assembly.id _pdbx_struct_assembly.details _pdbx_struct_assembly.method_details _pdbx_struct_assembly.oligomeric_details _pdbx_struct_assembly.oligomeric_count 1 author_and_software_defined_assembly PISA trimeric 3 2 author_and_software_defined_assembly PISA trimeric 3 # loop_ _pdbx_struct_assembly_gen.assembly_id _pdbx_struct_assembly_gen.oper_expression _pdbx_struct_assembly_gen.asym_id_list 1 1,2,3 A,C,D,E,F,J 2 1,4,5 B,G,H,I,K # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 1 'ABSA (A^2)' 12800 ? 1 MORE -39 ? 1 'SSA (A^2)' 49060 ? 2 'ABSA (A^2)' 12700 ? 2 MORE -37 ? 2 'SSA (A^2)' 48770 ? # loop_ _pdbx_struct_oper_list.id _pdbx_struct_oper_list.type _pdbx_struct_oper_list.name _pdbx_struct_oper_list.symmetry_operation _pdbx_struct_oper_list.matrix[1][1] _pdbx_struct_oper_list.matrix[1][2] _pdbx_struct_oper_list.matrix[1][3] _pdbx_struct_oper_list.vector[1] _pdbx_struct_oper_list.matrix[2][1] _pdbx_struct_oper_list.matrix[2][2] _pdbx_struct_oper_list.matrix[2][3] _pdbx_struct_oper_list.vector[2] _pdbx_struct_oper_list.matrix[3][1] _pdbx_struct_oper_list.matrix[3][2] _pdbx_struct_oper_list.matrix[3][3] _pdbx_struct_oper_list.vector[3] 1 'identity operation' 1_555 x,y,z 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 2 'crystal symmetry operation' 2_545 -y,x-y-1,z -0.5000000000 -0.8660254038 0.0000000000 38.7855000000 0.8660254038 -0.5000000000 0.0000000000 -67.1784565970 0.0000000000 0.0000000000 1.0000000000 0.0000000000 3 'crystal symmetry operation' 3_655 -x+y+1,-x,z -0.5000000000 0.8660254038 0.0000000000 77.5710000000 -0.8660254038 -0.5000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 4 'crystal symmetry operation' 2_445 -y-1,x-y-1,z -0.5000000000 -0.8660254038 0.0000000000 -38.7855000000 0.8660254038 -0.5000000000 0.0000000000 -67.1784565970 0.0000000000 0.0000000000 1.0000000000 0.0000000000 5 'crystal symmetry operation' 3_545 -x+y,-x-1,z -0.5000000000 0.8660254038 0.0000000000 38.7855000000 -0.8660254038 -0.5000000000 0.0000000000 -67.1784565970 0.0000000000 0.0000000000 1.0000000000 0.0000000000 # loop_ _pdbx_struct_special_symmetry.id _pdbx_struct_special_symmetry.PDB_model_num _pdbx_struct_special_symmetry.auth_asym_id _pdbx_struct_special_symmetry.auth_comp_id _pdbx_struct_special_symmetry.auth_seq_id _pdbx_struct_special_symmetry.PDB_ins_code _pdbx_struct_special_symmetry.label_asym_id _pdbx_struct_special_symmetry.label_comp_id _pdbx_struct_special_symmetry.label_seq_id 1 1 A HOH 691 ? J HOH . 2 1 A HOH 933 ? J HOH . 3 1 B HOH 813 ? K HOH . # loop_ _pdbx_struct_conn_angle.id _pdbx_struct_conn_angle.ptnr1_label_atom_id _pdbx_struct_conn_angle.ptnr1_label_alt_id _pdbx_struct_conn_angle.ptnr1_label_asym_id _pdbx_struct_conn_angle.ptnr1_label_comp_id _pdbx_struct_conn_angle.ptnr1_label_seq_id _pdbx_struct_conn_angle.ptnr1_auth_atom_id _pdbx_struct_conn_angle.ptnr1_auth_asym_id _pdbx_struct_conn_angle.ptnr1_auth_comp_id _pdbx_struct_conn_angle.ptnr1_auth_seq_id _pdbx_struct_conn_angle.ptnr1_PDB_ins_code _pdbx_struct_conn_angle.ptnr1_symmetry _pdbx_struct_conn_angle.ptnr2_label_atom_id _pdbx_struct_conn_angle.ptnr2_label_alt_id _pdbx_struct_conn_angle.ptnr2_label_asym_id _pdbx_struct_conn_angle.ptnr2_label_comp_id _pdbx_struct_conn_angle.ptnr2_label_seq_id _pdbx_struct_conn_angle.ptnr2_auth_atom_id _pdbx_struct_conn_angle.ptnr2_auth_asym_id _pdbx_struct_conn_angle.ptnr2_auth_comp_id _pdbx_struct_conn_angle.ptnr2_auth_seq_id _pdbx_struct_conn_angle.ptnr2_PDB_ins_code _pdbx_struct_conn_angle.ptnr2_symmetry _pdbx_struct_conn_angle.ptnr3_label_atom_id _pdbx_struct_conn_angle.ptnr3_label_alt_id _pdbx_struct_conn_angle.ptnr3_label_asym_id _pdbx_struct_conn_angle.ptnr3_label_comp_id _pdbx_struct_conn_angle.ptnr3_label_seq_id _pdbx_struct_conn_angle.ptnr3_auth_atom_id _pdbx_struct_conn_angle.ptnr3_auth_asym_id _pdbx_struct_conn_angle.ptnr3_auth_comp_id _pdbx_struct_conn_angle.ptnr3_auth_seq_id _pdbx_struct_conn_angle.ptnr3_PDB_ins_code _pdbx_struct_conn_angle.ptnr3_symmetry _pdbx_struct_conn_angle.value _pdbx_struct_conn_angle.value_esd 1 O ? K HOH . ? B HOH 789 ? 1_555 CD ? I CD . ? B CD 503 ? 1_555 NE2 ? B HIS 298 ? B HIS 282 ? 1_555 108.5 ? 2 O ? K HOH . ? B HOH 789 ? 1_555 CD ? I CD . ? B CD 503 ? 1_555 NE2 ? B HIS 43 ? B HIS 27 ? 1_555 107.5 ? 3 NE2 ? B HIS 298 ? B HIS 282 ? 1_555 CD ? I CD . ? B CD 503 ? 1_555 NE2 ? B HIS 43 ? B HIS 27 ? 1_555 96.8 ? 4 OE1 ? B GLU 327 ? B GLU 311 ? 1_555 CD ? D CD . ? A CD 502 ? 1_555 OE2 ? B GLU 327 ? B GLU 311 ? 1_555 53.9 ? 5 OE1 ? B GLU 327 ? B GLU 311 ? 1_555 CD ? D CD . ? A CD 502 ? 1_555 OD2 ? A ASP 114 ? A ASP 98 ? 1_555 149.3 ? 6 OE2 ? B GLU 327 ? B GLU 311 ? 1_555 CD ? D CD . ? A CD 502 ? 1_555 OD2 ? A ASP 114 ? A ASP 98 ? 1_555 96.6 ? 7 OE1 ? B GLU 327 ? B GLU 311 ? 1_555 CD ? D CD . ? A CD 502 ? 1_555 O ? J HOH . ? A HOH 710 ? 1_555 100.7 ? 8 OE2 ? B GLU 327 ? B GLU 311 ? 1_555 CD ? D CD . ? A CD 502 ? 1_555 O ? J HOH . ? A HOH 710 ? 1_555 153.2 ? 9 OD2 ? A ASP 114 ? A ASP 98 ? 1_555 CD ? D CD . ? A CD 502 ? 1_555 O ? J HOH . ? A HOH 710 ? 1_555 106.6 ? 10 OD1 ? A ASP 26 ? A ASP 10 ? 1_555 CD ? E CD . ? A CD 503 ? 1_555 OD2 ? A ASP 26 ? A ASP 10 ? 1_555 50.8 ? 11 OD1 ? A ASP 26 ? A ASP 10 ? 1_555 CD ? E CD . ? A CD 503 ? 1_555 O ? J HOH . ? A HOH 623 ? 1_555 106.8 ? 12 OD2 ? A ASP 26 ? A ASP 10 ? 1_555 CD ? E CD . ? A CD 503 ? 1_555 O ? J HOH . ? A HOH 623 ? 1_555 157.6 ? 13 OD1 ? A ASP 26 ? A ASP 10 ? 1_555 CD ? E CD . ? A CD 503 ? 1_555 O ? J HOH . ? A HOH 932 ? 1_555 88.7 ? 14 OD2 ? A ASP 26 ? A ASP 10 ? 1_555 CD ? E CD . ? A CD 503 ? 1_555 O ? J HOH . ? A HOH 932 ? 1_555 93.6 ? 15 O ? J HOH . ? A HOH 623 ? 1_555 CD ? E CD . ? A CD 503 ? 1_555 O ? J HOH . ? A HOH 932 ? 1_555 85.5 ? 16 OD1 ? B ASP 26 ? B ASP 10 ? 1_555 CD ? H CD . ? B CD 502 ? 1_555 OD2 ? B ASP 26 ? B ASP 10 ? 1_555 49.3 ? # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2012-12-19 2 'Structure model' 1 1 2013-01-30 3 'Structure model' 1 2 2013-02-06 4 'Structure model' 1 3 2017-11-15 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Derived calculations' 2 3 'Structure model' 'Database references' 3 4 'Structure model' 'Refinement description' # _pdbx_audit_revision_category.ordinal 1 _pdbx_audit_revision_category.revision_ordinal 4 _pdbx_audit_revision_category.data_content_type 'Structure model' _pdbx_audit_revision_category.category software # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal HKL-2000 'data collection' . ? 1 PHENIX refinement '(phenix.refine: 1.8_1069)' ? 2 HKL-2000 'data reduction' . ? 3 HKL-2000 'data scaling' . ? 4 # loop_ _pdbx_validate_close_contact.id _pdbx_validate_close_contact.PDB_model_num _pdbx_validate_close_contact.auth_atom_id_1 _pdbx_validate_close_contact.auth_asym_id_1 _pdbx_validate_close_contact.auth_comp_id_1 _pdbx_validate_close_contact.auth_seq_id_1 _pdbx_validate_close_contact.PDB_ins_code_1 _pdbx_validate_close_contact.label_alt_id_1 _pdbx_validate_close_contact.auth_atom_id_2 _pdbx_validate_close_contact.auth_asym_id_2 _pdbx_validate_close_contact.auth_comp_id_2 _pdbx_validate_close_contact.auth_seq_id_2 _pdbx_validate_close_contact.PDB_ins_code_2 _pdbx_validate_close_contact.label_alt_id_2 _pdbx_validate_close_contact.dist 1 1 O A HOH 774 ? ? O B HOH 848 ? ? 1.81 2 1 O B HOH 849 ? ? O B HOH 857 ? ? 1.81 3 1 NZ A LYS 284 ? ? O A HOH 831 ? ? 1.85 4 1 O A HOH 858 ? ? O A HOH 903 ? ? 1.85 5 1 OE2 B GLU 49 ? ? O B HOH 798 ? ? 1.86 6 1 OE2 A GLU 309 ? ? O A HOH 948 ? ? 1.87 7 1 O B GLY 104 ? ? O B HOH 901 ? ? 1.87 8 1 O B HOH 700 ? ? O B HOH 835 ? ? 1.88 9 1 OD1 A ASP 71 ? ? O A HOH 793 ? ? 1.90 10 1 O B HOH 872 ? ? O B HOH 891 ? ? 1.90 11 1 O B HOH 632 ? ? O B HOH 854 ? ? 1.95 12 1 O B HOH 870 ? ? O B HOH 887 ? ? 1.96 13 1 O B HOH 821 ? ? O B HOH 845 ? ? 1.97 14 1 OG B SER 29 ? ? O B HOH 823 ? ? 1.97 15 1 O B HOH 744 ? ? O B HOH 871 ? ? 1.98 16 1 O B HIS 158 ? ? O B HOH 786 ? ? 1.98 17 1 O B GLY 328 ? ? NZ B LYS 361 ? ? 1.98 18 1 O A HOH 922 ? ? O A HOH 949 ? ? 1.99 19 1 O B HOH 787 ? ? O B HOH 861 ? ? 2.00 20 1 O B SER 227 ? ? O B HOH 834 ? ? 2.03 21 1 O B LEU 236 ? ? O B HOH 797 ? ? 2.03 22 1 O A HOH 799 ? ? O A HOH 901 ? ? 2.04 23 1 O A HOH 934 ? ? O A HOH 943 ? ? 2.04 24 1 O B GLY 254 ? ? NE2 B GLN 256 ? ? 2.04 25 1 OE2 A GLU 79 ? ? O A HOH 908 ? ? 2.05 26 1 O B HOH 794 ? ? O B HOH 895 ? ? 2.05 27 1 O B HOH 874 ? ? O B HOH 885 ? ? 2.05 28 1 OG1 A THR 69 ? ? O A HOH 935 ? ? 2.05 29 1 O A THR 329 ? ? O A HOH 912 ? ? 2.06 30 1 O B HOH 642 ? ? O B HOH 744 ? ? 2.08 31 1 OE1 A GLU 314 ? ? O A HOH 945 ? ? 2.09 32 1 O A HOH 855 ? ? O A HOH 881 ? ? 2.10 33 1 O A HOH 658 ? ? O A HOH 953 ? ? 2.10 34 1 O B LYS 246 ? ? O B HOH 814 ? ? 2.10 35 1 OG1 A THR 142 ? ? O A HOH 864 ? ? 2.11 36 1 OE2 B GLU 229 ? ? O B HOH 803 ? ? 2.11 37 1 O B HOH 790 ? ? O B HOH 816 ? ? 2.11 38 1 O B HOH 884 ? ? O B HOH 889 ? ? 2.12 39 1 O B HOH 858 ? ? O B HOH 863 ? ? 2.12 40 1 O A HOH 886 ? ? O A HOH 897 ? ? 2.13 41 1 O A HOH 816 ? ? O A HOH 936 ? ? 2.14 42 1 OD1 B ASP 87 ? ? O B HOH 880 ? ? 2.16 43 1 NZ A LYS 36 ? ? OG1 A THR 293 ? ? 2.16 44 1 OE1 A GLU 269 ? ? O A HOH 844 ? ? 2.17 45 1 O A HOH 866 ? ? O A HOH 882 ? ? 2.17 46 1 OE1 A GLN 347 ? ? O A HOH 938 ? ? 2.17 47 1 O A HOH 885 ? ? O A HOH 952 ? ? 2.18 48 1 OE1 A GLU 314 ? ? O A HOH 951 ? ? 2.19 49 1 O A HOH 756 ? ? O A HOH 862 ? ? 2.19 50 1 OE1 A GLU 79 ? ? O A HOH 934 ? ? 2.19 # loop_ _pdbx_validate_symm_contact.id _pdbx_validate_symm_contact.PDB_model_num _pdbx_validate_symm_contact.auth_atom_id_1 _pdbx_validate_symm_contact.auth_asym_id_1 _pdbx_validate_symm_contact.auth_comp_id_1 _pdbx_validate_symm_contact.auth_seq_id_1 _pdbx_validate_symm_contact.PDB_ins_code_1 _pdbx_validate_symm_contact.label_alt_id_1 _pdbx_validate_symm_contact.site_symmetry_1 _pdbx_validate_symm_contact.auth_atom_id_2 _pdbx_validate_symm_contact.auth_asym_id_2 _pdbx_validate_symm_contact.auth_comp_id_2 _pdbx_validate_symm_contact.auth_seq_id_2 _pdbx_validate_symm_contact.PDB_ins_code_2 _pdbx_validate_symm_contact.label_alt_id_2 _pdbx_validate_symm_contact.site_symmetry_2 _pdbx_validate_symm_contact.dist 1 1 O A HOH 919 ? ? 1_555 O A HOH 928 ? ? 3_655 1.83 2 1 O A HOH 942 ? ? 1_555 O B HOH 901 ? ? 3_545 1.83 3 1 O B HOH 662 ? ? 1_555 O B HOH 662 ? ? 2_445 1.84 4 1 O B HOH 678 ? ? 1_555 O B HOH 678 ? ? 2_445 2.01 5 1 O A HOH 811 ? ? 1_555 O B HOH 754 ? ? 3_545 2.03 # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 LYS A 36 ? ? -53.03 99.46 2 1 ASP A 177 ? ? 73.77 -36.79 3 1 GLU A 202 ? ? 56.59 -113.56 4 1 LYS A 343 ? ? -111.72 61.67 5 1 ASN A 355 ? ? -111.59 72.28 6 1 HIS B 27 ? ? -36.97 128.60 7 1 THR B 76 ? ? 104.62 -12.42 8 1 GLN B 77 ? ? -99.28 30.02 9 1 THR B 95 ? ? 179.98 -177.01 10 1 ASN B 103 ? ? 23.35 53.75 11 1 ALA B 168 ? ? -118.24 77.88 12 1 ASP B 177 ? ? 72.87 -27.08 13 1 GLU B 202 ? ? 53.47 -113.61 14 1 SER B 227 ? ? -57.74 -79.67 15 1 LYS B 291 ? ? -48.84 99.53 16 1 ASN B 355 ? ? -103.92 73.02 17 1 ASP B 360 ? ? -160.67 118.03 18 1 GLU B 362 ? ? 70.49 -16.87 19 1 GLU B 384 ? ? -56.58 -7.29 # _pdbx_validate_peptide_omega.id 1 _pdbx_validate_peptide_omega.PDB_model_num 1 _pdbx_validate_peptide_omega.auth_comp_id_1 ALA _pdbx_validate_peptide_omega.auth_asym_id_1 B _pdbx_validate_peptide_omega.auth_seq_id_1 18 _pdbx_validate_peptide_omega.PDB_ins_code_1 ? _pdbx_validate_peptide_omega.label_alt_id_1 ? _pdbx_validate_peptide_omega.auth_comp_id_2 THR _pdbx_validate_peptide_omega.auth_asym_id_2 B _pdbx_validate_peptide_omega.auth_seq_id_2 19 _pdbx_validate_peptide_omega.PDB_ins_code_2 ? _pdbx_validate_peptide_omega.label_alt_id_2 ? _pdbx_validate_peptide_omega.omega 149.87 # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 Y 1 B GLU 84 ? CG ? B GLU 100 CG 2 1 Y 1 B GLU 84 ? CD ? B GLU 100 CD 3 1 Y 1 B GLU 84 ? OE1 ? B GLU 100 OE1 4 1 Y 1 B GLU 84 ? OE2 ? B GLU 100 OE2 5 1 Y 1 B HIS 244 ? CG ? B HIS 260 CG 6 1 Y 1 B HIS 244 ? ND1 ? B HIS 260 ND1 7 1 Y 1 B HIS 244 ? CD2 ? B HIS 260 CD2 8 1 Y 1 B HIS 244 ? CE1 ? B HIS 260 CE1 9 1 Y 1 B HIS 244 ? NE2 ? B HIS 260 NE2 10 1 Y 1 B LYS 246 ? CG ? B LYS 262 CG 11 1 Y 1 B LYS 246 ? CD ? B LYS 262 CD 12 1 Y 1 B LYS 246 ? CE ? B LYS 262 CE 13 1 Y 1 B LYS 246 ? NZ ? B LYS 262 NZ 14 1 Y 1 B LYS 247 ? CG ? B LYS 263 CG 15 1 Y 1 B LYS 247 ? CD ? B LYS 263 CD 16 1 Y 1 B LYS 247 ? CE ? B LYS 263 CE 17 1 Y 1 B LYS 247 ? NZ ? B LYS 263 NZ 18 1 Y 1 B LYS 343 ? CG ? B LYS 359 CG 19 1 Y 1 B LYS 343 ? CD ? B LYS 359 CD 20 1 Y 1 B LYS 343 ? CE ? B LYS 359 CE 21 1 Y 1 B LYS 343 ? NZ ? B LYS 359 NZ 22 1 Y 1 B GLU 362 ? CG ? B GLU 378 CG 23 1 Y 1 B GLU 362 ? CD ? B GLU 378 CD 24 1 Y 1 B GLU 362 ? OE1 ? B GLU 378 OE1 25 1 Y 1 B GLU 362 ? OE2 ? B GLU 378 OE2 26 1 Y 1 B LYS 385 ? CG ? B LYS 401 CG 27 1 Y 1 B LYS 385 ? CD ? B LYS 401 CD 28 1 Y 1 B LYS 385 ? CE ? B LYS 401 CE 29 1 Y 1 B LYS 385 ? NZ ? B LYS 401 NZ # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A GLY -15 ? A GLY 1 2 1 Y 1 A HIS -14 ? A HIS 2 3 1 Y 1 A HIS -13 ? A HIS 3 4 1 Y 1 A HIS -12 ? A HIS 4 5 1 Y 1 A HIS -11 ? A HIS 5 6 1 Y 1 A HIS -10 ? A HIS 6 7 1 Y 1 A HIS -9 ? A HIS 7 8 1 Y 1 A HIS -8 ? A HIS 8 9 1 Y 1 A HIS -7 ? A HIS 9 10 1 Y 1 A GLY -6 ? A GLY 10 11 1 Y 1 A SER -5 ? A SER 11 12 1 Y 1 A SER -4 ? A SER 12 13 1 Y 1 A THR -3 ? A THR 13 14 1 Y 1 A SER -2 ? A SER 14 15 1 Y 1 A ASN -1 ? A ASN 15 16 1 Y 1 A GLY 0 ? A GLY 16 17 1 Y 1 A MET 1 ? A MET 17 18 1 Y 1 A ASP 147 ? A ASP 163 19 1 Y 1 A GLN 148 ? A GLN 164 20 1 Y 1 A HIS 149 ? A HIS 165 21 1 Y 1 A GLN 150 ? A GLN 166 22 1 Y 1 A VAL 151 ? A VAL 167 23 1 Y 1 A GLY 152 ? A GLY 168 24 1 Y 1 A ASN 153 ? A ASN 169 25 1 Y 1 A GLU 154 ? A GLU 170 26 1 Y 1 A THR 155 ? A THR 171 27 1 Y 1 A THR 156 ? A THR 172 28 1 Y 1 A GLU 157 ? A GLU 173 29 1 Y 1 A HIS 158 ? A HIS 174 30 1 Y 1 A ALA 404 ? A ALA 420 31 1 Y 1 A THR 405 ? A THR 421 32 1 Y 1 A ALA 406 ? A ALA 422 33 1 Y 1 A ARG 407 ? A ARG 423 34 1 Y 1 A GLY 408 ? A GLY 424 35 1 Y 1 A ALA 409 ? A ALA 425 36 1 Y 1 A ARG 410 ? A ARG 426 37 1 Y 1 A ARG 411 ? A ARG 427 38 1 Y 1 B GLY -15 ? B GLY 1 39 1 Y 1 B HIS -14 ? B HIS 2 40 1 Y 1 B HIS -13 ? B HIS 3 41 1 Y 1 B HIS -12 ? B HIS 4 42 1 Y 1 B HIS -11 ? B HIS 5 43 1 Y 1 B HIS -10 ? B HIS 6 44 1 Y 1 B HIS -9 ? B HIS 7 45 1 Y 1 B HIS -8 ? B HIS 8 46 1 Y 1 B HIS -7 ? B HIS 9 47 1 Y 1 B GLY -6 ? B GLY 10 48 1 Y 1 B SER -5 ? B SER 11 49 1 Y 1 B SER -4 ? B SER 12 50 1 Y 1 B THR -3 ? B THR 13 51 1 Y 1 B SER -2 ? B SER 14 52 1 Y 1 B ASN -1 ? B ASN 15 53 1 Y 1 B GLY 0 ? B GLY 16 54 1 Y 1 B MET 1 ? B MET 17 55 1 Y 1 B HIS 101 ? B HIS 117 56 1 Y 1 B GLY 146 ? B GLY 162 57 1 Y 1 B ASP 147 ? B ASP 163 58 1 Y 1 B GLN 148 ? B GLN 164 59 1 Y 1 B HIS 149 ? B HIS 165 60 1 Y 1 B GLN 150 ? B GLN 166 61 1 Y 1 B VAL 151 ? B VAL 167 62 1 Y 1 B GLY 152 ? B GLY 168 63 1 Y 1 B ASN 153 ? B ASN 169 64 1 Y 1 B GLU 154 ? B GLU 170 65 1 Y 1 B THR 155 ? B THR 171 66 1 Y 1 B THR 156 ? B THR 172 67 1 Y 1 B GLU 157 ? B GLU 173 68 1 Y 1 B THR 405 ? B THR 421 69 1 Y 1 B ALA 406 ? B ALA 422 70 1 Y 1 B ARG 407 ? B ARG 423 71 1 Y 1 B GLY 408 ? B GLY 424 72 1 Y 1 B ALA 409 ? B ALA 425 73 1 Y 1 B ARG 410 ? B ARG 426 74 1 Y 1 B ARG 411 ? B ARG 427 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 'CADMIUM ION' CD 4 'CHLORIDE ION' CL 5 water HOH # _pdbx_reflns_twin.domain_id ? _pdbx_reflns_twin.crystal_id 1 _pdbx_reflns_twin.diffrn_id 1 _pdbx_reflns_twin.type merohedral _pdbx_reflns_twin.operator h,-h-k,-l _pdbx_reflns_twin.fraction 0.400 #